LOCUS 024_IIG_Bs27_001_SNP 3686305 bp DNA circular UNA 12-JAN-2021 DEFINITION Bacillus subtilis strain Delta6 (hybrid trycycler assembly). ACCESSION urn.local...1dv-cvskbtd VERSION urn.local...1dv-cvskbtd KEYWORDS . SOURCE ORGANISM . FEATURES Location/Qualifiers S_feature complement(3686195..658) /Source="Nicolas_S_feature" /locus_tag="new_299_1067_c" /HighExp="S4, LoTm, S3, C30, S5, S7, S6, T5.0H, S8, M9-stat" /AntisenseName="dnaA" /AntisenseCor="-0.57810076860528403" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S4" CDS 1..1341 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2167836, 2846289, 12682299, 16120674, 1779750, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2167836, 2846289, 12682299, 16120674, 1779750, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosomal replication initiator informational ATPase" /protein_id="NP_387882.1" /db_xref="EnsemblGenomes-Gn:BSU00010" /db_xref="EnsemblGenomes-Tr:CAB11777" /db_xref="GOA:P05648" /db_xref="InterPro:IPR001957" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013159" /db_xref="InterPro:IPR013317" /db_xref="InterPro:IPR018312" /db_xref="InterPro:IPR020591" /db_xref="InterPro:IPR024633" /db_xref="InterPro:IPR027417" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG10065" /db_xref="UniProtKB/Swiss-Prot:P05648" /translation="MENILDLWNQALAQIEKKLSKPSFETWMKSTKAHSLQGDTLTIT APNEFARDWLESRYLHLIADTIYELTGEELSIKFVIPQNQDVEDFMPKPQVKKAVKED TSDFPQNMLNPKYTFDTFVIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHL MHAIGHYVIDHNPSAKVVYLSSEKFTNEFINSIRDNKAVDFRNRYRNVDVLLIDDIQF LAGKEQTQEEFFHTFNTLHEESKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPP DLETRIAILRKKAKAEGLDIPNEVMLYIANQIDSNIRELEGALIRVVAYSSLINKDIN ADLAAEALKDIIPSSKPKVITIKEIQRVVGQQFNIKLEDFKAKKRTKSVAFPRQIAMY LSREMTDSSLPKIGEEFGGRDHTTVIHAHEKISKLLADDEQLQQHVKEIKEQLK*" /label="dnaA CDS" gene 1..1341 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /label="dnaA gene" promotor_-10 complement(631..649) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(657) /Source="Nicolas_upshifts" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(665..670) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1342..1529 /Source="Nicolas_S_feature" /locus_tag="new_1751_1938" /HighExp="G150, Heat, G180, G135, Paraq, Oxctl, dia0, LBGstat, S1, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S5" CDS 1530..2666 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2846289, 11395445, 12682299, 20453097, 23228104, 28878042" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846289, 11395445, 12682299, 20453097, 23228104, 28878042; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (beta subunit)" /protein_id="NP_387883.1" /db_xref="EnsemblGenomes-Gn:BSU00020" /db_xref="EnsemblGenomes-Tr:CAB11778" /db_xref="GOA:P05649" /db_xref="InterPro:IPR001001" /db_xref="InterPro:IPR022634" /db_xref="InterPro:IPR022635" /db_xref="InterPro:IPR022637" /db_xref="PDB:4TR6" /db_xref="SubtiList:BG10066" /db_xref="UniProtKB/Swiss-Prot:P05649" /translation="MKFTIQKDRLVESVQDVLKAVSSRTTIPILTGIKIVASDDGVSF TGSDSDISIESFIPKEEGDKEIVTIEQPGSIVLQARFFSEIVKKLPMATVEIEVQNQY LTIIRSGKAEFNLNGLDADEYPHLPQIEEHHAIQIPTDLLKNLIRQTVFAVSTSETRP ILTGVNWKVEQSELLCTATDSHRLALRKAKLDIPEDRSYNVVIPGKSLTELSKILDDN QELVDIVITETQVLFKAKNVLFFSRLLDGNYPDTTSLIPQDSKTEIIVNTKEFLQAID RASLLAREGRNNVVKLSAKPAESIEISSNSPEIGKVVEAIVADQIEGEELNISFSPKY MLDALKVLEGAEIRVSFTGAMRPFLIRTPNDETIVQLILPVRTY*" /label="dnaN CDS" gene 1530..2666 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /label="dnaN gene" downshifts 2650 /Source="Nicolas_upshifts" /id="D1" /incds=0 /nref=29 /ntot=161 /MaxReadThrough="5.22584" /MaxDrop="4.17087" /score="21.887269" /energy="-14.2" /TU="U1" /idTUdmin="U1" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" promotor_-35 2731..2735 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2752..2771 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2760 /Source="Nicolas_upshifts" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="upshifts" CDS 2797..3012 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24637032, 24939895" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24637032, 24939895; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA binding protein involved in ribosome maturation" /protein_id="NP_387884.1" /db_xref="EnsemblGenomes-Gn:BSU00030" /db_xref="EnsemblGenomes-Tr:CAB11779" /db_xref="GOA:P05650" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014330" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10067" /db_xref="UniProtKB/Swiss-Prot:P05650" /translation="MANPISIDTEMITLGQFLKLADVIQSGGMAKWFLSEHEVLVNDE PDNRRGRKLYVGDVVEIEGFGSFQVVN*" /label="rlbA CDS" gene 2797..3012 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /label="rlbA gene" CDS 3028..4140 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 16061691, 16385024, 22342069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 16061691, 16385024, 22342069; Product type f: factor" /codon_start=1 /transl_table=11 /product="RecA filament-DNA complex stabilisation, ssDNA and dsDNA binding, ATP binding" /protein_id="NP_387885.1" /db_xref="EnsemblGenomes-Gn:BSU00040" /db_xref="EnsemblGenomes-Tr:CAB11780" /db_xref="GOA:P05651" /db_xref="InterPro:IPR001238" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR018078" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10068" /db_xref="UniProtKB/Swiss-Prot:P05651" /translation="MYIQNLELTSYRNYDHAELQFENKVNVIIGENAQGKTNLMEAIY VLSMAKSHRTSNDKELIRWDKDYAKIEGRVMKQNGAIPMQLVISKKGKKGKVNHIEQQ KLSQYVGALNTIMFAPEDLNLVKGSPQVRRRFLDMEIGQVSPVYLHDLSLYQKILSQR NHFLKQLQTRKQTDRTMLDVLTDQLVEVAAKVVVKRLQFTAQLEKWAQPIHAGISRGL EELTLKYHTALDVSDPLDLSKIGDSYQEAFSKLREKEIERGVTLSGPHRDDVLFYVNG RDVQTYGSQGQQRTTALSLKLAEIDLIHEEIGEYPILLLDDVLSELDDYRQSHLLHTI QGRVQTFVTTTSVDGIDHETLRQAGMFRVQNGALVK*" /label="recF CDS" gene 3028..4140 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /label="recF gene" misc_feature 3226..3245 /Source="Nicolas_upshift_promotors" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3244 /Source="Nicolas_upshifts" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="upshifts" CDS 4158..4403 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of extracellular matrix formation" /protein_id="NP_387886.2" /db_xref="EnsemblGenomes-Gn:BSU00050" /db_xref="EnsemblGenomes-Tr:CAB11781" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG10069" /db_xref="UniProtKB/Swiss-Prot:P37525" /translation="MYIHLGDDFVVSTRDIVGIFDFKANMSPIVEEFLKKQKHKVVPS VNGTPKSIVVTVQNIYYSPLSSSTLKKRAQFMFEIDS*" /label="remB CDS" gene 4158..4403 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /label="remB gene" CDS 4458..6374 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit B)" /protein_id="NP_387887.1" /db_xref="EnsemblGenomes-Gn:BSU00060" /db_xref="EnsemblGenomes-Tr:CAB11782" /db_xref="GOA:P05652" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR011557" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR034160" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10070" /db_xref="UniProtKB/Swiss-Prot:P05652" /translation="MEQQQNSYDENQIQVLEGLEAVRKRPGMYIGSTNSKGLHHLVWE IVDNSIDEALAGYCTDINIQIEKDNSITVVDNGRGIPVGIHEKMGRPAVEVIMTVLHA GGKFDGSGYKVSGGLHGVGASVVNALSTELDVTVHRDGKIHRQTYKRGVPVTDLEIIG ETDHTGTTTHFVPDPEIFSETTEYDYDLLANRVRELAFLTKGVNITIEDKREGQERKN EYHYEGGIKSYVEYLNRSKEVVHEEPIYIEGEKDGITVEVALQYNDSYTSNIYSFTNN INTYEGGTHEAGFKTGLTRVINDYARKKGLIKENDPNLSGDDVREGLTAIISIKHPDP QFEGQTKTKLGNSEARTITDTLFSTAMETFMLENPDAAKKIVDKGLMAARARMAAKKA RELTRRKSALEISNLPGKLADCSSKDPSISELYIVEGDSAGGSAKQGRDRHFQAILPL RGKILNVEKARLDKILSNNEVRSMITALGTGIGEDFNLEKARYHKVVIMTDADVDGAH IRTLLLTFFYRYMRQIIENGYVYIAQPPLYKVQQGKRVEYAYNDKELEELLKTLPQTP KPGLQRYKGLGEMNATQLWETTMDPSSRTLLQVTLEDAMDADETFEMLMGDKVEPRRN FIEANARYVKNLDI*" /label="gyrB CDS" gene 4458..6374 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /label="gyrB gene" promotor_-10 complement(6003..6021) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(6005) /Source="Nicolas_upshifts" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(6037..6042) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 6375..6584 /Source="Nicolas_S_feature" /locus_tag="new_6784_6993" /HighExp="Cold, H2O2, G180, Oxctl, G135, G150, Sw, dia15, LBGexp, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S6" CDS 6585..9050 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /EC_number="5.99.1.3" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901, 27557712" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901, 27557712; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit A)" /protein_id="NP_387888.1" /db_xref="EnsemblGenomes-Gn:BSU00070" /db_xref="EnsemblGenomes-Tr:CAB11783" /db_xref="GOA:P05653" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005743" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="PDB:4DDQ" /db_xref="SubtiList:BG10071" /db_xref="UniProtKB/Swiss-Prot:P05653" /translation="MSEQNTPQVREINISQEMRTSFLDYAMSVIVSRALPDVRDGLKP VHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYM LVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVM PSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEVIPGPDF PTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEK IADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINL LALVDGQPKVLTLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEGLRVALDHLDA VISLIRNSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKL IAELKDILANEYKVLEIIREELTEIKERFNDERRTEIVTSGLETIEDEDLIERENIVV TLTHNGYVKRLPASTYRSQKRGGKGVQGMGTNEDDFVEHLISTSTHDTILFFSNKGKV YRAKGYEIPEYGRTAKGIPIINLLEVEKGEWINAIIPVTEFNAELYLFFTTKHGVSKR TSLSQFANIRNNGLIALSLREDDELMGVRLTDGTKQIIIGTKNGLLIRFPETDVREMG RTAAGVKGITLTDDDVVVGMEILEEESHVLIVTEKGYGKRTPAEEYRTQSRGGKGLKT AKITENNGQLVAVKATKGEEDLMIITASGVLIRMDINDISITGRVTQGVRLIRMAEEE HVATVALVEKNEEDENEEEQEEV*" /label="gyrA CDS" gene 6585..9050 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /label="gyrA gene" promotor_-35 8964..8967 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 8965 /Source="Nicolas_upshifts" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 8984..9001 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 9031 /Source="Nicolas_upshifts" /id="D2" /incds=0 /nref=251 /ntot=261 /MaxReadThrough="3.73971" /MaxDrop="8.1288" /score="33.5021066" /energy="-14.1" /TU="NA" /idTUdmin="U4" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 9095..9101 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 9115..9134 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 9120..9205 /Source="Nicolas_S_feature" /locus_tag="new_9529_9614" /HighExp="LBGstat, H2O2, Paraq, Oxctl, UNK1, LBGexp, LPhT, MG-0.2, MG 25, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S7" upshifts 9120 /Source="Nicolas_upshifts" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 9191..9198 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 9207 /Source="Nicolas_upshifts" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 9213..9232 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" rRNA 9401..10955 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-16S rRNA" gene 9401..10955 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /label="rrnO-16S gene" tRNA 11055..11131 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnO-Ile tRNA" gene 11055..11131 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /label="trnO-Ile gene" tRNA 11143..11218 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnO-Ala tRNA" gene 11143..11218 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /label="trnO-Ala gene" rRNA 11300..14227 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-23S rRNA" gene 11300..14227 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /label="rrnO-23S gene" rRNA 14283..14401 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-5S rRNA" gene 14283..14401 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /label="rrnO-5S gene" S_feature 14402..15459 /Source="Nicolas_S_feature" /locus_tag="new_14811_15868" /HighExp="G180, T0.0H, T0.30H, G135, T-0.40H, LBGstat, Cold, Paraq, C30, Oxctl" /AntisenseName="yaaC" /AntisenseCor="-4.5985764709218099E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S8" CDS complement(14438..15385) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387889.1" /db_xref="EnsemblGenomes-Gn:BSU00080" /db_xref="EnsemblGenomes-Tr:CAB11784" /db_xref="InterPro:IPR026988" /db_xref="SubtiList:BG10072" /db_xref="UniProtKB/Swiss-Prot:P37526" /translation="MTYHEWKDLALFYSVESTQKFLEKVYILNGINDAKKNSFKNSER FIYFLKHAESFYKQAAYSPLEIKPILLFYGMAQLIKACLITRDPHYPSHTSVLAHGVT TRKRKKQNYCFSDDEVKIQRNGLCVHFMKHLFGQSDIVDERYTMKKLLMAIPELSDIF YFQQKERFMTKVEKDKNEIFVPEEVVINYKMSDSRFAEYMSHHYQWSFTKKNEHGLLF EISPQDKEPWTSTSLLFDMEKNQYYIPSQREQFLRLPEMTIHYLILYNVGMIARYETE WWYELLTQHISDDYVLIQQFLLVSEKKFPKYASQFLLHF*" /label="yaaC CDS" gene complement(14438..15385) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /label="yaaC gene" promotor_-35 15438..15445 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 15460..15479 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 15461 /Source="Nicolas_upshifts" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(15466) /Source="Nicolas_upshifts" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(15475..15486) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(15500..15506) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 15506..16972 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /EC_number="1.1.1.205" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1722815, 17611193, 1979163, 3125411, 8917437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1722815, 17611193, 1979163, 3125411, 8917437; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inosine-monophosphate dehydrogenase" /protein_id="NP_387890.1" /db_xref="EnsemblGenomes-Gn:BSU00090" /db_xref="EnsemblGenomes-Tr:CAB11785" /db_xref="GOA:P21879" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005990" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG10073" /db_xref="UniProtKB/Swiss-Prot:P21879" /translation="MWESKFSKEGLTFDDVLLVPAKSEVLPRDVDLSVELTKTLKLNI PVISAGMDTVTESAMAIAMARQGGLGIIHKNMSIEQQAEQVDKVKRSERGVITNPFFL TPDHQVFDAEHLMGKYRISGVPIVNNEEDQKLVGIITNRDLRFISDYSMKISDVMTKE ELVTASVGTTLDEAEKILQKHKIEKLPLVDDQNKLKGLITIKDIEKVIEFPNSSKDIH GRLIVGAAVGVTGDTMTRVKKLVEANVDVIVIDTAHGHSQGVLNTVTKIRETYPELNI IAGNVATAEATRALIEAGADVVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKH GKTIIADGGIKFSGDITKALAAGGHAVMLGSLLAGTSESPGETEIYQGRRFKVYRGMG SVAAMEKGSKDRYFQEENKKFVPEGIEGRTPYKGPVEETVYQLVGGLRSGMGYCGSKD LRALREEAQFIRMTGAGLRESHPHDVQITKESPNYTIS*" /label="guaB CDS" gene 15506..16972 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /label="guaB gene" downshifts complement(15510) /Source="Nicolas_upshifts" /id="D3" /incds=0 /nref=33 /ntot=102 /MaxReadThrough="1.81989" /MaxDrop="4.44626" /score="-6.76739893" /energy="-12.2" /TU="NA" /idTUdmin="U12" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(15536..15636) /Source="Nicolas_upshift_promotors" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(15576) /Source="Nicolas_upshifts" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(16829..17424) /Source="Nicolas_S_feature" /locus_tag="new_17238_17833_c" /HighExp="Etha, Gly, C30, Salt, S8, S6, HiTm, S7, Sw, C90" /AntisenseName="dacA" /AntisenseCor="-0.39306815699287101" /AntisenseRegPval="-10.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S9" downshifts 16960 /Source="Nicolas_upshifts" /id="D4" /incds=0 /nref=243 /ntot=277 /MaxReadThrough="3.34899" /MaxDrop="7.78161" /score="26.7620012" /energy="-10.6" /TU="NA" /idTUdmin="U10" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-35 17018..17022 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 17038..17057 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 17044..17124 /Source="Nicolas_S_feature" /locus_tag="new_17453_17533" /HighExp="C30, LBGstat, G180, G150, LBGexp, G135, Lbexp, Oxctl, dia0, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S10" upshifts 17044 /Source="Nicolas_upshifts" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="upshifts" CDS 17125..18456 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /EC_number="3.4.16.4" /experiment="publication(s) with functional evidences, PMID:8370539, 9864321, 10383963, 21378199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8370539, 9864321, 10383963, 21378199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5)" /protein_id="NP_387891.1" /db_xref="EnsemblGenomes-Gn:BSU00100" /db_xref="EnsemblGenomes-Tr:CAB11786" /db_xref="GOA:P08750" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10074" /db_xref="UniProtKB/Swiss-Prot:P08750" /translation="MNIKKCKQLLMSLVVLTLAVTCLAPMSKAKAASDPIDINASAAI MIEASSGKILYSKNADKRLPIASMTKMMTEYLLLEAIDQGKVKWDQTYTPDDYVYEIS QDNSLSNVPLRKDGKYTVKELYQATAIYSANAAAIAIAEIVAGSETKFVEKMNAKAKE LGLTDYKFVNATGLENKDLHGHQPEGTSVNEESEVSAKDMAVLADHLITDYPEILETS SIAKTKFREGTDDEMDMPNWNFMLKGLVSEYKKATVDGLKTGSTDSAGSCFTGTAERN GMRVITVVLNAKGNLHTGRFDETKKMFDYAFDNFSMKEIYAEGDQVKGHKTISVDKGK EKEVGIVTNKAFSLPVKNGEEKNYKAKVTLNKDNLTAPVKKGTKVGKLTAEYTGDEKD YGFLNSDLAGVDLVTKENVEKANWFVLTMRSIGGFFAGIWGSIVDTVTGWF*" /label="dacA CDS" gene 17125..18456 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /label="dacA gene" promotor_-10 complement(17413..17431) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(17424) /Source="Nicolas_upshifts" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(17446..17452) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 18338 /Source="Nicolas_upshifts" /id="D5" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="6.76335" /MaxDrop="2.1925" /score="26.7620012" /energy="-10.6" /TU="U13" /idTUdmin="U10" /TUdmin=1364 /isTUend="FALSE" /label="downshifts" S_feature 18457..18565 /Source="Nicolas_S_feature" /locus_tag="new_18866_18974" /HighExp="C30, MG 15, MG 10, MG-0.1, MG 25, BMM, ferm, Cold, MG 60, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S11" promotor_-35 18535..18538 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 18553..18572 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 18567..18652 /Source="Nicolas_S_feature" /locus_tag="new_18976_19061" /HighExp="BMM, MG 25, SMM, MG 15, UNK1, MG 10, GM 150, MG-0.1, MG 150, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S12" upshifts 18567 /Source="Nicolas_upshifts" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="upshifts" CDS 18653..19537 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /EC_number="4.3.3.6" /EC_number="4.-.-.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14762015, 15771487, 15911615, 16157873, 17144654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762015, 15771487, 15911615, 16157873, 17144654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, synthase subunit" /protein_id="NP_387892.1" /db_xref="EnsemblGenomes-Gn:BSU00110" /db_xref="EnsemblGenomes-Tr:CAB11787" /db_xref="GOA:P37527" /db_xref="InterPro:IPR001852" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033755" /db_xref="PDB:2NV1" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10075" /db_xref="UniProtKB/Swiss-Prot:P37527" /translation="MAQTGTERVKRGMAEMQKGGVIMDVINAEQAKIAEEAGAVAVMA LERVPADIRAAGGVARMADPTIVEEVMNAVSIPVMAKARIGHIVEARVLEAMGVDYID ESEVLTPADEEFHLNKNEYTVPFVCGCRDLGEATRRIAEGASMLRTKGEPGTGNIVEA VRHMRKVNAQVRKVVAMSEDELMTEAKNLGAPYELLLQIKKDGKLPVVNFAAGGVATP ADAALMMQLGADGVFVGSGIFKSDNPAKFAKAIVEATTHFTDYKLIAELSKELGTAMK GIEISNLLPEQRMQERGW*" /label="pdxS CDS" gene 18653..19537 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /label="pdxS gene" S_feature complement(18785..19514) /Source="Nicolas_S_feature" /locus_tag="new_19194_19923_c" /HighExp="S6, S8, S7, S5, S4, C30, S3, BT, C90, Gly" /AntisenseName="pdxS" /AntisenseCor="-0.65390240445415004" /AntisenseRegPval="-33.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S13" promotor_-10 complement(19502..19520) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(19514) /Source="Nicolas_upshifts" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(19536..19541) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-35" CDS 19559..20149 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /EC_number="3.5.1.2" /EC_number="4.3.3.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 14762015, 15771487, 17144654, 18271580, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 14762015, 15771487, 17144654, 18271580, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, glutamine amidotransferase subunit PdxT" /protein_id="NP_387893.1" /db_xref="EnsemblGenomes-Gn:BSU00120" /db_xref="EnsemblGenomes-Tr:CAB11788" /db_xref="GOA:P37528" /db_xref="InterPro:IPR002161" /db_xref="InterPro:IPR021196" /db_xref="InterPro:IPR029062" /db_xref="PDB:1R9G" /db_xref="PDB:2NV0" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10076" /db_xref="UniProtKB/Swiss-Prot:P37528" /translation="MLTIGVLGLQGAVREHIHAIEACGAAGLVVKRPEQLNEVDGLIL PGGESTTMRRLIDTYQFMEPLREFAAQGKPMFGTCAGLIILAKEIAGSDNPHLGLLNV VVERNSFGRQVDSFEADLTIKGLDEPFTGVFIRAPHILEAGENVEVLSEHNGRIVAAK QGQFLGCSFHPELTEDHRVTQLFVEMVEEYKQKALV*" /label="pdxT CDS" gene 19559..20149 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /label="pdxT gene" misc_RNA 20202..20414 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /product="T-box riboswitch specific of serine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboS RNA" gene 20202..20414 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /label="tboS gene" downshifts 20379 /Source="Nicolas_upshifts" /id="D6" /incds=0 /nref=9 /ntot=80 /MaxReadThrough="7.14793" /MaxDrop="4.37654" /score="41.1243331" /energy="-23.3" /TU="U13,U15" /idTUdmin="U13" /TUdmin="-1347" /isTUend="FALSE" /label="downshifts" CDS 20471..21748 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /EC_number="6.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10546897, 12682299, 14732487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10546897, 12682299, 14732487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="seryl-tRNA synthetase" /protein_id="NP_387894.1" /db_xref="EnsemblGenomes-Gn:BSU00130" /db_xref="EnsemblGenomes-Tr:CAB11789" /db_xref="GOA:P37464" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002317" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR015866" /db_xref="InterPro:IPR033729" /db_xref="SubtiList:BG10077" /db_xref="UniProtKB/Swiss-Prot:P37464" /translation="MLDTKMLRANFQEIKAKLVHKGEDLTDFDKFEALDDRRRELIGK VEELKGKRNEVSQQVAVLKREKKDADHIIKEMREVGEEIKKLDEELRTVEAELDTILL SIPNIPHESVPVGETEDDNVEVRKWGEKPSFAYEPKPHWDIADELGILDFERAAKVTG SRFVFYKGLGARLERALYNFMLDLHVDEYNYTEVIPPYMVNRASMTGTGQLPKFEEDA FKIREEDYFLIPTAEVPITNMHRDEILSGDSLPINYAAFSACFRSEAGSAGRDTRGLI RQHQFNKVELVKFVKPEDSYEELEKLTNQAERVLQLLELPYRVMSMCTGDLGFTAAKK YDIEVWIPSQDTYREISSCSNFEAFQARRANIRFRREAKGKPEHVHTLNGSGLAVGRT VAAILENYQQEDGSVVIPKVLRPYMGNREVMKP*" /label="serS CDS" gene 20471..21748 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /label="serS gene" downshifts 21726 /Source="Nicolas_upshifts" /id="D7" /incds=0 /nref=234 /ntot=255 /MaxReadThrough="0.83411" /MaxDrop="7.38039" /score="17.6549558" /energy="-13.3" /TU="NA" /idTUdmin="U13" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 21837..21844 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 21859..21878 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 21859 /Source="Nicolas_upshifts" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="upshifts" tRNA 21883..21975 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(UGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Ser1 tRNA" gene 21883..21975 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /label="trnSL-Ser1 gene" downshifts 21998 /Source="Nicolas_upshifts" /id="D8" /incds=0 /nref=168 /ntot=196 /MaxReadThrough="5.02201" /MaxDrop="8.36635" /score="29.7083093" /energy="-12.4" /TU="U17" /idTUdmin="U13" /TUdmin=272 /isTUend="FALSE" /label="downshifts" S_feature 22043..22120 /Source="Nicolas_S_feature" /locus_tag="new_22452_22529" /HighExp="Cold, H2O2, G180, Paraq, Oxctl, C30, G150, G135, BMM, Heat" /AntisenseName="dck" /AntisenseCor="0.61769771609764101" /AntisenseRegPval="-29" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S14" CDS complement(22087..22740) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /EC_number="2.7.1.76" /EC_number="2.7.1.74" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6251049, 11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6251049, 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyadenosine/deoxycytidine kinase" /protein_id="NP_387895.1" /db_xref="EnsemblGenomes-Gn:BSU00140" /db_xref="EnsemblGenomes-Tr:CAB11790" /db_xref="GOA:P37529" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10078" /db_xref="UniProtKB/Swiss-Prot:P37529" /translation="MKEHHIPKNSIITVAGTVGVGKSTLTKTLAKRLGFKTSLEEVDH NPYLEKFYHDFERWSFHLQIYFLAERFKEQKTIFEAGGGFVQDRSIYEDTGIFAKMHA DKGTMSKVDYKTYTSLFEAMVMTPYFPHPDVLIYLEGDLENILNRIEQRGREMELQTS RSYWEEMHTRYENWISGFNACPVLKLRIEDYDLLNDENSIENIVDQIASVIHDNQKK* " /label="dck CDS" gene complement(22087..22740) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /label="dck gene" promotor_-35 22106..22112 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(22111) /Source="Nicolas_upshifts" /id="D9" /incds=0 /nref=88 /ntot=213 /MaxReadThrough="1.96668" /MaxDrop="4.49235" /score="14.5948578" /energy="-11" /TU="NA" /idTUdmin="U19" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature 22122..22758 /Source="Nicolas_S_feature" /locus_tag="new_22531_23167" /HighExp="G180, G135, Cold, C30, Paraq, H2O2, Oxctl, G150, S5, S6" /AntisenseName="dck" /AntisenseCor="0.15155468296621499" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S15" upshifts 22122 /Source="Nicolas_upshifts" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 22126..22137 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(22737..23360) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /EC_number="2.7.1.113" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyguanosine kinase" /protein_id="NP_387896.1" /db_xref="EnsemblGenomes-Gn:BSU00150" /db_xref="EnsemblGenomes-Tr:CAB11791" /db_xref="GOA:P37530" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10079" /db_xref="UniProtKB/Swiss-Prot:P37530" /translation="MNTAPFIAIEGPIGAGKTTLATMLSQKFGFPMINEIVEDNPYLD KFYDNIKEWSFQLEMFFLCHRYKQLEDTSDHFLKKGQPVIADYHIYKNVIFAERTLSP HQLEKYKKIYHLLTDDLPKPNFIIYIKASLPTLLHRIEKRGRPFEKKIETSYLEQLIS DYEVAIKQLQEADPELTVLTVDGDSKDFVLNKSDFERIAAHVKELIV*" /label="dgk CDS" gene complement(22737..23360) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /label="dgk gene" promotor_-10 complement(23401..23420) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(23419) /Source="Nicolas_upshifts" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(23436..23440) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(23459..24742) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /EC_number="3.2.1.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11011148, 11737650, 12177332, 10419957, 18456807, 18835992, 19933362, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore peptidoglycan N-acetylglucosaminidase" /protein_id="NP_387897.1" /db_xref="EnsemblGenomes-Gn:BSU00160" /db_xref="EnsemblGenomes-Tr:CAB11792" /db_xref="GOA:P37531" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10080" /db_xref="UniProtKB/Swiss-Prot:P37531" /translation="MVKQGDTLSAIASQYRTTTNDITETNEIPNPDSLVVGQTIVIPI AGQFYDVKRGDTLTSIARQFNTTAAELARVNRIQLNTVLQIGFRLYIPPAPKRDIESN AYLEPRGNQVSENLQQAAREASPYLTYLGAFSFQAQRNGTLVAPPLTNLRSITESQNT TLMMIITNLENQAFSDELGRILLNDETVKRRLLNEIVENARRYGFRDIHFDFEYLRPQ DREAYNQFLREARDLFHREGLEISTALAPKTSATQQGRWYEAHDYRAHGEIVDFVVLM TYEWGYSGGPPQAVSPIGPVRDVIEYALTEMPANKIVMGQNLYGYDWTLPYTAGGTPA RAVSPQQAIVIADQNNASIQYDQTAQAPFFRYTDAENRRHEVWFEDARSIQAKFNLIK ELNLRGISYWKLGLSFPQNWLLLSDQFNVVKKTFR*" /label="sleL CDS" gene complement(23459..24742) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /label="sleL gene" downshifts complement(23496) /Source="Nicolas_upshifts" /id="D10" /incds=0 /nref=40 /ntot=61 /MaxReadThrough="1.17442" /MaxDrop="6.30997" /score="3.66560192" /energy="-8.4" /TU="NA" /idTUdmin="U20" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(24773..24791) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(24794) /Source="Nicolas_upshifts" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(24807..24812) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(24812..25357) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2521622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidase (isochorismatase family)" /protein_id="NP_387898.1" /db_xref="EnsemblGenomes-Gn:BSU00170" /db_xref="EnsemblGenomes-Tr:CAB11793" /db_xref="GOA:P37532" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG10081" /db_xref="UniProtKB/Swiss-Prot:P37532" /translation="MSKADKALLIVDMINNFEFDMGETLAKKTEKIVPHILSLKEHAR QNEWPIIYINDHYGLWQADIKNIQQECTNERSKDIITKIAPVDADYFLIKPKHSAFYE TALHTLLTELQVRHIIITGIAGNICVLFTANDAYMREYSITIPKDCIASNSDEDNEFA LTMMENVLFAEITTEEQIIEK*" /label="yaaI CDS" gene complement(24812..25357) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /label="yaaI gene" promotor_-35 25223..25227 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25242..25261 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" S_feature 25246..25442 /Source="Nicolas_S_feature" /locus_tag="new_25655_25851" /HighExp="Diami, dia5, H2O2, dia15, T0.30H, T-0.40H, HiOs, T-1.10H, Salt, T0.0H" /AntisenseName="yaaI" /AntisenseCor="9.6546810160837798E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S16" upshifts 25248 /Source="Nicolas_upshifts" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="upshifts" promotor_-10 complement(25382..25400) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(25401) /Source="Nicolas_upshifts" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(25415..25421) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 25443..25928 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /EC_number="3.5.4.33" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15677468, 16014871, 16415880, 16700551, 23658230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA specific adenosine A34 deaminase" /protein_id="NP_387899.1" /db_xref="EnsemblGenomes-Gn:BSU00180" /db_xref="EnsemblGenomes-Tr:CAB11794" /db_xref="GOA:P21335" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR028883" /db_xref="SubtiList:BG10082" /db_xref="UniProtKB/Swiss-Prot:P21335" /translation="MTQDELYMKEAIKEAKKAEEKGEVPIGAVLVINGEIIARAHNLR ETEQRSIAHAEMLVIDEACKALGTWRLEGATLYVTLEPCPMCAGAVVLSRVEKVVFGA FDPKGGCSGTLMNLLQEERFNHQAEVVSGVLEEECGGMLSAFFRELRKKKKAARKNLS E*" /label="tadA CDS" gene 25443..25928 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /label="tadA gene" promotor_-35 25932..25938 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25952..25971 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" misc_RNA 25970..26323 /gene="scr" /locus_tag="BSU_misc_RNA_2" /product="small cytoplasmic RNA (scRNA, 4.5S RNA), signal recognition particle-like (SRP) component" /experiment="publication(s) with functional evidences, PMID:1372600, 1689715" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1372600, 1689715" /label="scr RNA" gene 25970..26323 /gene="scr" /locus_tag="BSU_misc_RNA_2" /label="scr gene" S_feature 25974..26123 /Source="Nicolas_S_feature" /locus_tag="new_26383_26532" /HighExp="T1.0H, T5.0H, T1.30H, T3.30H, T3.0H, T2.30H, T4.0H, S8, T-1.10H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S17" upshifts 25974 /Source="Nicolas_upshifts" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="upshifts" S_feature 26227..26322 /Source="Nicolas_S_feature" /locus_tag="new_26636_26731" /HighExp="S8, Sw, B60, B36, T2.30H, T3.30H, T1.0H, BC, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S18" downshifts 26279 /Source="Nicolas_upshifts" /id="D11" /incds=0 /nref=273 /ntot=278 /MaxReadThrough="4.46774" /MaxDrop="8.31255" /score="23.257527" /energy="-10.3" /TU="U21,U23" /idTUdmin="U21" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 26343..26346 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 26361..26380 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 26370 /Source="Nicolas_upshifts" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="upshifts" CDS 26405..28096 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III subunit tau subunit" /protein_id="NP_387900.2" /db_xref="EnsemblGenomes-Gn:BSU00190" /db_xref="EnsemblGenomes-Tr:CAB11795" /db_xref="GOA:P09122" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR012763" /db_xref="InterPro:IPR022754" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10083" /db_xref="UniProtKB/Swiss-Prot:P09122" /translation="MSYQALYRVFRPQRFEDVVGQEHITKTLQNALLQKKFSHAYLFS GPRGTGKTSAAKIFAKAVNCEHAPVDEPCNECAACKGITNGSISDVIEIDAASNNGVD EIRDIRDKVKFAPSAVTYKVYIIDEVHMLSIGAFNALLKTLEEPPEHCIFILATTEPH KIPLTIISRCQRFDFKRITSQAIVGRMNKIVDAEQLQVEEGSLEIIASAADGGMRDAL SLLDQAISFSGDILKVEDALLITGAVSQLYIGKLAKSLHDKNVSDALETLNELLQQGK DPAKLIEDMIFYFRDMLLYKTAPGLEGVLEKVKVDETFRELSEQIPAQALYEMIDILN KSHQEMKWTNHPRIFFEVAVVKICQTSHQSAADLPEVDMLMKKIQQLEQEVERLKTTG IKAAAESPKKEAPRVPKGGKSNYKAPVGRIHEILKEATRPDLDLLRNSWGKLLAHLKQ QNKVSHAALLNDSEPVAAGSAAFVLKFKYEIHCKMVAEDNNGVRTNLEQILESMLGKR MDLIGVPEAQWGKIREEFLEDHQQENEGSNEPAEEDPLIAEAKKLVGADLIEIKD*" /label="dnaX CDS" gene 26405..28096 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /label="dnaX gene" promotor_-35 27937..27944 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 27959..27978 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 27974 /Source="Nicolas_upshifts" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="upshifts" CDS 28120..28443 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16740939, 19208644, 19594923, 20639362, 22333191, 22544270; Product type f : factor" /codon_start=1 /transl_table=11 /product="nucleoid associated protein" /protein_id="NP_387901.1" /db_xref="EnsemblGenomes-Gn:BSU00200" /db_xref="EnsemblGenomes-Tr:CAB11796" /db_xref="GOA:P24281" /db_xref="InterPro:IPR004401" /db_xref="InterPro:IPR036894" /db_xref="SubtiList:BG10084" /db_xref="UniProtKB/Swiss-Prot:P24281" /translation="MRGGMGNMQKMMKQMQKMQKDMAKAQEELAEKVVEGTAGGGMVT VKANGQKEILDVIIKEEVVDPEDIDMLQDLVLAATNEALKKVDEITNETMGQFTKGMN MPGLF*" /label="ebfC CDS" gene 28120..28443 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /label="ebfC gene" CDS 28458..29054 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12065426, 24285298, 24891441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065426, 24285298, 24891441; Product type f: factor" /codon_start=1 /transl_table=11 /product="recA filament-DNA complex stabilisation factor" /protein_id="NP_387902.1" /db_xref="EnsemblGenomes-Gn:BSU00210" /db_xref="EnsemblGenomes-Tr:CAB11797" /db_xref="GOA:P24277" /db_xref="InterPro:IPR000093" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR015967" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR023627" /db_xref="InterPro:IPR023628" /db_xref="InterPro:IPR034137" /db_xref="SubtiList:BG10085" /db_xref="UniProtKB/Swiss-Prot:P24277" /translation="MQYPEPISKLIDSFMKLPGIGPKTAVRLAFFVLGMKEDVVLDFA KALVNAKRNLTYCSVCGHITDQDPCYICEDTRRDKSVICVVQDPKDVIAMEKMKEYNG QYHVLHGAISPMDGIGPEDIKIPELLKRLQDDQVTEVILATNPNIEGEATAMYISRLL KPSGIKLSRIAHGLPVGGDLEYADEVTLSKALEGRREL*" /label="recR CDS" gene 28458..29054 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /label="recR gene" CDS 29072..29296 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387903.1" /db_xref="EnsemblGenomes-Gn:BSU00220" /db_xref="EnsemblGenomes-Tr:CAB11798" /db_xref="InterPro:IPR019644" /db_xref="SubtiList:BG10086" /db_xref="UniProtKB/Swiss-Prot:P37533" /translation="MGFLRKKTLRREFDEKLTEQLFKQKEEWNRQKKLVEKSLEPSAE VLYELKVAEAKYFFYLREAKQRNLKISRWK*" /label="yaaL CDS" gene 29072..29296 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /label="yaaL gene" promotor_-35 29299..29304 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-35" upshifts 29316 /Source="Nicolas_upshifts" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="upshifts" promotor_-10 29320..29338 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-10" CDS 29363..29626 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15087499, 17557826" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15087499, 17557826; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the pro-sigma(K) processing machinery" /protein_id="NP_387904.2" /db_xref="EnsemblGenomes-Gn:BSU00230" /db_xref="EnsemblGenomes-Tr:CAB11799" /db_xref="GOA:P24282" /db_xref="InterPro:IPR010001" /db_xref="SubtiList:BG10087" /db_xref="UniProtKB/Swiss-Prot:P24282" /translation="MEPIFIIGIILGLVILLFLSGSAAKPLKWIGITAVKFVAGALLL VCVNMFGGSLGIHVPINLVTTAISGILGIPGIAALVVIKQFII*" /label="bofA CDS" gene 29363..29626 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /label="bofA gene" promotor_-35 29639..29646 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 29660..29679 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 29667..29869 /Source="Nicolas_S_feature" /locus_tag="new_30076_30278" /HighExp="LBGstat, Diami, C30, H2O2, Oxctl, HPh, BMM, GM 120, Paraq, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.899, 0.99" /label="S19" upshifts 29667 /Source="Nicolas_upshifts" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="upshifts" rRNA 29870..31423 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-16S" gene 29870..31423 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /label="rrnA-16S gene" tRNA 31523..31599 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ile(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnA-Ile" gene 31523..31599 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /label="trnA-Ile gene" tRNA 31611..31686 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnA-Ala" gene 31611..31686 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /label="trnA-Ala gene" rRNA 31768..34694 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-23S" gene 31768..34694 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /label="rrnA-23S gene" S_feature 34695..34827 /Source="Nicolas_S_feature" /locus_tag="new_35104_35236" /HighExp="LBGstat, G135, Oxctl, C30, HPh, Paraq, G180, LPh, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S20" rRNA 34828..34946 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-5S" gene 34828..34946 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /label="rrnA-5S gene" S_feature 34947..35049 /Source="Nicolas_S_feature" /locus_tag="new_35356_35458" /HighExp="Oxctl, Paraq, H2O2, LBGstat, C30, G180, Cold, G135, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S21" promotor_-35 35010..35018 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-35" promotor_-10 35032..35051 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-10" upshifts 35051 /Source="Nicolas_upshifts" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="upshifts" CDS 35122..35316 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8759874, 15044948, 21935351, 26929302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759874, 15044948, 21935351, 26929302; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="forespore-specific anti-sigma factor" /protein_id="NP_387905.1" /db_xref="EnsemblGenomes-Gn:BSU00240" /db_xref="EnsemblGenomes-Tr:CAB11800" /db_xref="GOA:P37534" /db_xref="InterPro:IPR019700" /db_xref="SubtiList:BG10088" /db_xref="UniProtKB/Swiss-Prot:P37534" /translation="MDETVKLNHTCVICDQEKNRGIHLYTKFICLDCERKVISTSTSD PDYAFYVKKLKSIHTPPLYS*" /label="csfB CDS" gene 35122..35316 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /label="csfB gene" downshifts 35300 /Source="Nicolas_upshifts" /id="D12" /incds=0 /nref=79 /ntot=215 /MaxReadThrough="5.37774" /MaxDrop="4.42494" /score="22.3916007" /energy="-6.7" /TU="U28" /idTUdmin="U27" /TUdmin=3938 /isTUend="FALSE" /label="downshifts" promotor_-35 35361..35370 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 35382..35397 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 35388 /Source="Nicolas_upshifts" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="upshifts" CDS 35436..36050 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23155385; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatase" /protein_id="NP_387906.1" /db_xref="EnsemblGenomes-Gn:BSU00250" /db_xref="EnsemblGenomes-Tr:CAB11801" /db_xref="GOA:P37467" /db_xref="InterPro:IPR018770" /db_xref="SubtiList:BG10089" /db_xref="UniProtKB/Swiss-Prot:P37467" /translation="MQRFFHFLVWSLTSSATFVFIGILSFFGLNQSIFLSIVYGLASG AAVYIAGIWNARRLFLKKHELTGREYAYIKKNLEEARQKMVRLRKALFQAKSIQMFKQ NAEMLRIVRRIYLLTKKEPKRFYQAERFFYQTLDSVVELTEKYAFLSSHPKKSKELSM SLSETRITLTELTKRLEEDLTQAMGDEIDELQFELDAAKHSLKK*" /label="xpaC CDS" gene 35436..36050 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /label="xpaC gene" CDS 36069..37229 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12533473, 20713661" /codon_start=1 /transl_table=11 /product="putative toxic compound resistance protein" /protein_id="NP_387907.1" /db_xref="EnsemblGenomes-Gn:BSU00260" /db_xref="EnsemblGenomes-Tr:CAB11802" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG10090" /db_xref="UniProtKB/Swiss-Prot:P37535" /translation="MNRDQSDLHIDELLADPFGGNIEIPGSEAVKAEKEQVRLVDVLP EENKEKAIQLAGQIDHKNMQSIVLYGSQAQSKLLNFSHDMINHVQKKDVGEIGEILGE LMKKLEQVNPDDLQSKKKGFLARMFGRVSSSLQEVLSKYQKTSVQIDRISLKLEHSKN ALISDNKLLEQLYEKNKEYFAALNVYIAAGELKLEELKTKTIPELKQQAESSDHNQMA VQEVNDLIQFADRLDKRVHDLLLSRQITIQSAPQIRLIQNTNQALAEKIQSSIVTAIP LWKNQVAIALTLLRQRNAVDAQQKVSDTTNELLLKNAELLKTNTIETARANERGLVDI DTLKKVQESLISTLEETLTIQEEGRIKRRQAEEELMMMEGDLKQKLITIKER*" /label="yaaN CDS" gene 36069..37229 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /label="yaaN gene" S_feature 37230..37310 /Source="Nicolas_S_feature" /locus_tag="new_37639_37719" /HighExp="T0.0H, T-0.40H, T0.30H, T-1.10H, T-1.40H, Salt, T1.0H, G150, Diami, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="0.984, 0.715" /TUlongSig="NA" /TUlongPSig="NA" /label="S22" CDS 37311..38753 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9723923, 20876533, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative decarboxylase" /protein_id="NP_387908.1" /db_xref="EnsemblGenomes-Gn:BSU00270" /db_xref="EnsemblGenomes-Tr:CAB11803" /db_xref="GOA:P37536" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10091" /db_xref="UniProtKB/Swiss-Prot:P37536" /translation="MNTPLYKALIQHARRNSHSFHVPGHHNGDVFFDDAKSIFDPLLT IDVTELAGLDDLHHPSGVIKEAQELASQLYGSAESFFLVNGTTVGNLAMILSVCEPGD TILVQRNCHKSVFHAVDLSGAEPVYLAPDVDSAMHVPTHVPLGTIKEALEAYPDAKGL VLTNPTYYGHSADLTEIITEAHHYGIPVLVDEAHGAHFILGEPFPVSALKMGADIVVQ SAHKTLPAMTMGSYLHLNSSCRINRDRVAEYLNRLQSSSPSYPIMASLDIARAYVQHI IEEQKLSDILQRIETLKQTFDSLTNAEAVNPANPLIITDPLKLTIRSKRGHSGYTLQS ILERANIFTELADENQVLLVLPLGGKRRINAEIIRSIDEEIEKTPPDQTFVSAEWGVQ PVTVLPYPKKVLHSFKKEYVSFEEAAGRLNAEDIIPYPPGIPMIMAGERITKESVQKL SRLISMKTHVQGNMKIKEKQLLVYIEEEKS*" /label="yaaO CDS" gene 37311..38753 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /label="yaaO gene" promotor_-35 38673..38679 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-35" promotor_-10 38694..38712 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-10" upshifts 38703 /Source="Nicolas_upshifts" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="upshifts" CDS 38750..39388 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /EC_number="2.7.4.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696781, 12682299, 18523102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696781, 12682299, 18523102; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate kinase" /protein_id="NP_387909.2" /db_xref="EnsemblGenomes-Gn:BSU00280" /db_xref="EnsemblGenomes-Tr:CAB11804" /db_xref="GOA:P37537" /db_xref="InterPro:IPR018094" /db_xref="InterPro:IPR018095" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10092" /db_xref="UniProtKB/Swiss-Prot:P37537" /translation="MSGLFITFEGPEGAGKTTVLQEIKNILTAEGLQVMATREPGGID IAEQIREVILNENNILMDPKTEALLYAAARRQHLVEKVKPALEQGFIVLCDRFIDSSL AYQGYARGLGIDEVLSINEFAIGDMMPHVTVYFSIDPEEGLKRIYANGSREKNRLDLE KLDFHTKVQEGYQELMKRFPERFHSVDAGQSKDLVVQDVLKVIDEALKKIQL*" /label="tmk CDS" gene 38750..39388 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /label="tmk gene" promotor_-35 39383..39390 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 39403..39422 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 39414 /Source="Nicolas_upshifts" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="upshifts" CDS 39462..39791 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /experiment="publication(s) with functional evidences, PMID:10913081, 25433025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 25433025; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal transduction receptor, cyclic di-AMP binding" /protein_id="NP_387910.1" /db_xref="EnsemblGenomes-Gn:BSU00290" /db_xref="EnsemblGenomes-Tr:CAB11805" /db_xref="InterPro:IPR010375" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="PDB:4RLE" /db_xref="SubtiList:BG10093" /db_xref="UniProtKB/Swiss-Prot:P37538" /translation="MKLIVAVVQDQDSNRLLKTLTDHNFRVTKLATTGGFLKSGNTTF MIGVEDIRVNKALSLIKENGQKRDQMIAPVSPMGGNADSYVPYPVEVEVGGATVFVLP VDEFHQF*" /label="darA CDS" gene 39462..39791 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /label="darA gene" CDS 39804..40244 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387911.1" /db_xref="EnsemblGenomes-Gn:BSU00300" /db_xref="EnsemblGenomes-Tr:CAB11806" /db_xref="InterPro:IPR005585" /db_xref="InterPro:IPR024042" /db_xref="SubtiList:BG10094" /db_xref="UniProtKB/Swiss-Prot:P37539" /translation="MKINKDIRTFIDNKQIPSVKTSEITASFKTSMENQSSKMKLDQL TRLLSDIEAFGKRLTKSRNFKDLARFKGLVKRFVKEAVDSGLSHETSKSFDLYGNSRT LGLVKEIDDKLIQLTEEMMDQEKPAIDLLERIGEIKGLLINLYT*" /label="yaaR CDS" gene 39804..40244 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /label="yaaR gene" CDS 40256..41245 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8509334, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8509334, 12060778, 12682299, 22333191, 23525462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III clamp loader delta' subunit" /protein_id="NP_387912.1" /db_xref="EnsemblGenomes-Gn:BSU00310" /db_xref="EnsemblGenomes-Tr:CAB11807" /db_xref="GOA:P37540" /db_xref="InterPro:IPR004622" /db_xref="InterPro:IPR015199" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10095" /db_xref="UniProtKB/Swiss-Prot:P37540" /translation="MAISWKEMNELQPRVMKLLYNSIEKDRLSHAYLFEGKKGTGKLD AALLLAKSFFCLEGGAEPCESCRNCKRIESGNHPDLHLVQPDGLSIKKAQIQALQEEF SKTGLESHKKLYIISHADQMTANAANSLLKFLEEPNKDTMAVLITEQPQRLLDTIISR CQTLPFQPLQPKAIEDRLIEQDVSPHMARLLANMTNNVAEAVELSRNDEFAESRAKVI KLYEVLHQRKGHAFFFIQDQWMPFFKEKTHQEMGLDMLLLIYRDVLSIQIGNEDKLIY QDLFQSIKQHALQSTQQSVTNQILAVLEAKKRLHSNVNVQGLMEHLVLMLQEG*" /label="holB CDS" gene 40256..41245 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /label="holB gene" CDS 41248..42075 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12270811, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12270811, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex of RNaseY (RicAFT complex /FAD / two [4Fe-4S]2+)" /protein_id="NP_387913.1" /db_xref="EnsemblGenomes-Gn:BSU00320" /db_xref="EnsemblGenomes-Tr:CAB11808" /db_xref="GOA:P37541" /db_xref="InterPro:IPR007557" /db_xref="SubtiList:BG10096" /db_xref="UniProtKB/Swiss-Prot:P37541" /translation="MYNVIGVRFKKAGKIYYFDPNGFHIEHDSCVIVETVRGVEYGQV VIANKQVDEHDVVLPLRKVIRVADDRDLLIVEENKQEALSAFDICQKKVIEHGLDMKL VDVEFTFDRNKVIFYFTADGRVDFRELVKDLASIFKTRIELRQIGVRDEAKMLGGIGP CGRMLCCSTFLGDFEPVSIKMAKDQNLSLNPTKISGLCGRLMCCLKYENDEYETAKEQ LPDIGEMITTANGPAKVVGLNILERVLQVELINREKVIEYTWEELLEEGVVSAQTTD* " /label="ricT CDS" gene 41248..42075 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /label="ricT gene" CDS 42090..42449 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15927750, 16461910, 19737352, 21895792, 23909787, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15927750, 16461910, 19737352, 21895792, 23909787, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="subunit of the DNA replication complex" /protein_id="NP_387914.1" /db_xref="EnsemblGenomes-Gn:BSU00330" /db_xref="EnsemblGenomes-Tr:CAB11809" /db_xref="GOA:P37542" /db_xref="InterPro:IPR010377" /db_xref="PDB:5DOL" /db_xref="SubtiList:BG10097" /db_xref="UniProtKB/Swiss-Prot:P37542" /translation="MDKKELFDTVINLEEQIGSLYRQLGDLKQHIGEMIEENHHLQLE NKHLRKRLDDTTQQIEKFKADKKESKTQKTEQTDIGEGYDNLARLYQEGFHICNVHYG SVRKEDCLFCLSFLNKK*" /label="dnaH CDS" gene 42090..42449 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /label="dnaH gene" CDS 42508..43251 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /EC_number="2.1.1.223" /function="10.3: tRNA and rRNA base modification" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22905870, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA1(Val) (adenine(37)-N6)-methyltransferase" /protein_id="NP_387915.1" /db_xref="EnsemblGenomes-Gn:BSU00340" /db_xref="EnsemblGenomes-Tr:CAB11810" /db_xref="GOA:P37543" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10098" /db_xref="UniProtKB/Swiss-Prot:P37543" /translation="MVSLHDDERLDYLLAEDMKIIQSPTVFAFSLDAVLLSKFAYVPI QKGKIVDLCTGNGIVPLLLSTRSKADILGVEIQERLHDMAVRSVEYNKLDDQIQIIHD DLKNMPEKLGHNRYDVVTCNPPYFKTPKQTEQNMNEHLRIARHEIHCTLEDVISVSSK LLKQGGKAALVHRPGRLLEIFELMKAYQIEPKRVQFVYPKQGKEANTILVEGIKGGRP DLKILPPLFVYDEQNEYTKEIRTILYGDK*" /label="trmNF CDS" gene 42508..43251 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /label="trmNF gene" CDS 43238..43537 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11483577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UvrC-Intron-type (URI) endonuclease" /protein_id="NP_387916.1" /db_xref="EnsemblGenomes-Gn:BSU00350" /db_xref="EnsemblGenomes-Tr:CAB11811" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG12700" /db_xref="UniProtKB/Swiss-Prot:O31414" /translation="METNNHFFYVVKCKDNSWYAGYTNDLHKRVKTHNDGKGAKYTKV RRPVELIFAESFSTKREAMQAEYYFKKLTRKKKELYIEEKRNSKEAVYVKAPNEL*" /label="yazA CDS" gene 43238..43537 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /label="yazA gene" CDS 43512..44390 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /EC_number="2.1.1.198" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 19965768, 25893373; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA 2'-O-ribose C1402 methyltransferase" /protein_id="NP_387917.1" /db_xref="EnsemblGenomes-Gn:BSU00360" /db_xref="EnsemblGenomes-Tr:CAB11812" /db_xref="GOA:P37544" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR008189" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR018063" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10099" /db_xref="UniProtKB/Swiss-Prot:P37544" /translation="MLRRQMSFNGKSDMGILYLVPTPIGNLEDMTFRAIDTLKSVDAI AAEDTRQTKKLCHVYEIETPLVSYHEHNKESSGHKIIEWLKSGKNIALVSDAGLPTIS DPGAEIVKDFTDIGGYVVPLPGANAALTALIASGIVPQPFFFYGFLNRQKKEKKKELE ALKKRQETIIFYEAPHRLKETLSAMAEILGDREIAVTRELTKKYEEFIRGTISEVIGW ANEDQIRGEFCLVVEGSNNEEVDEEEQWWETLTAKEHVEHYISKGATSKEAIKKAAVD RNVPKREVYDAYHIKQ*" /label="rsmI CDS" gene 43512..44390 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /label="rsmI gene" downshifts 44363 /Source="Nicolas_upshifts" /id="D13" /incds=0 /nref=23 /ntot=177 /MaxReadThrough="3.33195" /MaxDrop="3.72723" /score="5.97354542" /energy="-10.2" /TU="U29,U31" /idTUdmin="U29" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(44439..44729) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for transition state genes (AbrB-SurF)" /protein_id="NP_387918.1" /db_xref="EnsemblGenomes-Gn:BSU00370" /db_xref="EnsemblGenomes-Tr:CAB11813" /db_xref="GOA:P08874" /db_xref="InterPro:IPR007159" /db_xref="PDB:1YFB" /db_xref="PDB:1YSF" /db_xref="PDB:1Z0R" /db_xref="PDB:2K1N" /db_xref="PDB:2MJG" /db_xref="PDB:2RO4" /db_xref="SubtiList:BG10100" /db_xref="UniProtKB/Swiss-Prot:P08874" /translation="MFMKSTGIVRKVDELGRVVIPIELRRTLGIAEKDALEIYVDDEK IILKKYKPNMTCQVTGEVSDDNLKLAGGKLVLSKEGAEQIISEIQNQLQNLK*" /label="abrB CDS" gene complement(44439..44729) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /label="abrB gene" downshifts complement(44441) /Source="Nicolas_upshifts" /id="D14" /incds=0 /nref=216 /ntot=263 /MaxReadThrough="2.17237" /MaxDrop="7.75729" /score="20.9582436" /energy="-10.2" /TU="U32" /idTUdmin="U32" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" downshifts 44760 /Source="Nicolas_upshifts" /id="D15" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="2.53543" /MaxDrop="4.31699" /score="13.7153159" /energy="-14.4" /TU="NA" /idTUdmin="U29" /TUdmin=374 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(44796..44815) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(44813) /Source="Nicolas_upshifts" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(44815..44990) /Source="Nicolas_S_feature" /locus_tag="new_45224_45399_c" /HighExp="C30, H2O2, G180, Etha, S0, GM 25, Gly, G135, MG 25, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S23" promotor_-35 complement(44829..44836) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(44986..45005) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-10" upshifts complement(44990) /Source="Nicolas_upshifts" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="upshifts" promotor_-35 complement(45019..45026) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-35" promotor_-35 45090..45094 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-35" promotor_-10 45109..45128 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-10" S_feature 45115..45223 /Source="Nicolas_S_feature" /locus_tag="new_45524_45632" /HighExp="LBGtran, Heat, dia5, dia15, LBGexp, Lbexp, dia0, H2O2, Diami, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S24" upshifts 45115 /Source="Nicolas_upshifts" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="upshifts" CDS 45224..47218 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /EC_number="6.1.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11233169, 12682299, 12792655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA synthetase" /protein_id="NP_387919.1" /db_xref="EnsemblGenomes-Gn:BSU00380" /db_xref="EnsemblGenomes-Tr:CAB11814" /db_xref="GOA:P37465" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004495" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014758" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR023457" /db_xref="InterPro:IPR033911" /db_xref="SubtiList:BG10101" /db_xref="UniProtKB/Swiss-Prot:P37465" /translation="MPQENNTFYITTPIYYPSGKLHIGHAYTTVAGDAMARYKRLKGF DVRYLTGTDEHGQKIQQKAEQENITPQEYVDRAAADIQKLWKQLEISNDDFIRTTEKR HKVVIEKVFQKLLDNGDIYLDEYEGWYSIPDETFYTETQLVDIERNEKGEVIGGKSPD SGHPVELIKEESYFFRMGKYADRLLKYYEENPTFIQPESRKNEMINNFIKPGLEDLAV SRTTFDWGVKVPENPKHVVYVWIDALFNYLTALGYDTENDELYQKYWPADVHLVGKEI VRFHTIYWPIMLMALDLPLPKQVFAHGWLLMKDGKMSKSKGNVVDPVTLIERYGLDEL RYYLLREVPFGSDGVFTPEGFVERINYDLANDLGNLLNRTVAMINKYFDGQIGSYKGA VTEFDHTLTSVAEETVKAYEKAMENMEFSVALSTLWQLISRTNKYIDETAPWVLAKDP AKEEELRSVMYHLAESLRISAVLLQPFLTKTPEKMFEQLGITDESLKAWDSITAFGQL KDTKVQKGEPLFPRLEAEEEIAYIKGKMQGSAPAKEETKEEEPQEVDRLPEITIDQFM DVELRVAEVIEAEPVKKADRLLKLQLDLGFEKRQVVSGIAKHYTPEELVGKKLVCVTN LKPVKLRGELSQGMILAGEADGVLKVVSIDQSLPKGTRIK*" /label="metS CDS" gene 45224..47218 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /label="metS gene" promotor_-10 complement(45972..45991) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(45980) /Source="Nicolas_upshifts" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(46007..46011) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 47202 /Source="Nicolas_upshifts" /id="D16" /incds=0 /nref=18 /ntot=206 /MaxReadThrough="4.8491" /MaxDrop="2.9167" /score="13.7153159" /energy="-14.4" /TU="U34" /idTUdmin="U34" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" S_feature complement(47264..49610) /Source="Nicolas_S_feature" /locus_tag="new_47673_50019_c" /HighExp="T0.30H, T1.0H, T1.30H, Salt, C30, T2.0H, T-0.40H, T0.0H, T2.30H, T-1.10H" /AntisenseName="yabE" /AntisenseCor="-0.28154713646185298" /AntisenseRegPval="-5.6" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S25" CDS 47297..48064 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10747959, 16014871, 16461678, 19332551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acyl-tRNA deacylase" /protein_id="NP_387920.1" /db_xref="EnsemblGenomes-Gn:BSU00390" /db_xref="EnsemblGenomes-Tr:CAB11815" /db_xref="GOA:P37545" /db_xref="InterPro:IPR001130" /db_xref="InterPro:IPR015991" /db_xref="InterPro:IPR018228" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10102" /db_xref="UniProtKB/Swiss-Prot:P37545" /translation="MLFDTHAHLNAEQYDTDLEEVIERAKAEKVERIVVVGFDRPTIT RAMEMIEEYDFIYAAIGWHPVDAIDMTEEDLAWIKELSAHEKVVAIGEMGLDYHWDKS PKDIQKEVFRNQIALAKEVNLPIIIHNRDATEDVVTILKEEGAEAVGGIMHCFTGSAE VARECMKMNFYLSFGGPVTFKNAKKPKEVVKEIPNDRLLIETDCPFLTPHPFRGKRNE PSYVKYVAEQIAELKEMTFEEIASITTENAKRLFRIN*" /label="dayD CDS" gene 47297..48064 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /label="dayD gene" S_feature 48065..48145 /Source="Nicolas_S_feature" /locus_tag="new_48474_48554" /HighExp="Heat, C30, LBGtran, LBGstat, C90, Etha, M40t45, LPhT, MG 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S26" promotor_-35 48122..48127 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 48143..48161 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 48147 /Source="Nicolas_upshifts" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 48172..48175 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-35" promotor_-10 48190..48209 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-10" upshifts 48207 /Source="Nicolas_upshifts" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="upshifts" CDS 48220..49533 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15774001, 19047346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall shaping enzyme" /protein_id="NP_387921.1" /db_xref="EnsemblGenomes-Gn:BSU00400" /db_xref="EnsemblGenomes-Tr:CAB11816" /db_xref="GOA:P37546" /db_xref="InterPro:IPR007137" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR011098" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG10103" /db_xref="UniProtKB/Swiss-Prot:P37546" /translation="MGEREGRVDSLLDTLYNLSEEKEAFFITQKMKKLFSVKLSKSKV ILVAACLLLAGSGTAYAAHELTKQSVSVSINGKKKHIRTHANTVGDLLETLDIKTRDE DKITPAKQTKITADMDVVYEAAKPVKLTINGEEKTLWSTAKTVGALLDEQDVDVKEQD QIDPAIDTDISKDMKINIEPAFQVTVNDAGKQKKIWTTSTTVADFLKQQKMNIKDEDK IKPALDAKLTKGKADITITRIEKVTDVVEEKIAFDVKKQEDASLEKGKEKVVQKGKEG KLKKHFEVVKENGKEVSRELVKEETAEQSKDKVIAVGTKQSSPKFETVSASGDSKTVV SRSNESTGKVMTVSSTAYTASCSGCSGHTATGVNLKNNPNAKVIAVDPNVIPLGSKVH VEGYGYAIAADTGSAIKGNKIDVFFPEKSSAYRWGNKTVKIKILN*" /label="yabE CDS" gene 48220..49533 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /label="yabE gene" promotor_-35 48240..48247 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 48258 /Source="Nicolas_upshifts" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 48262..48281 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 49494 /Source="Nicolas_upshifts" /id="D17" /incds=0 /nref=87 /ntot=220 /MaxReadThrough="5.02755" /MaxDrop="4.87493" /score="27.529638" /energy="-11.3" /TU="U36,U37,U38" /idTUdmin="U34" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-35 49556..49560 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 49576..49595 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 49578..49677 /Source="Nicolas_S_feature" /locus_tag="new_49987_50086" /HighExp="LoTm, H2O2, G180, G135, G150, Paraq, Oxctl, C30, dia15, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.843, 0.943" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S27" upshifts 49578 /Source="Nicolas_upshifts" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(49602..49617) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(49618) /Source="Nicolas_upshifts" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(49629..49638) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 49674..49690 /Source="Nicolas_upshift_promotors" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 49678..50238 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /EC_number="3.1.26.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11233981, 11976317, 12794188, 16077031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11233981, 11976317, 12794188, 16077031; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease M5" /protein_id="NP_387922.1" /db_xref="EnsemblGenomes-Gn:BSU00410" /db_xref="EnsemblGenomes-Tr:CAB11817" /db_xref="GOA:P37547" /db_xref="InterPro:IPR004466" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR025156" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG10104" /db_xref="UniProtKB/Swiss-Prot:P37547" /translation="MKIKEIIVVEGRDDTARIKLAVDADTIETNGSAIDDHVIDQIRL AQKTRGVIILTDPDFPGEKIRKTISEAVPGCKHAFLPKHLAKPKNKRGIGVEHASVES IRACLENVHEEMEAQPSDISAEDLIHAGLIGGPAAKCRRERLGDLLKIGYTNGKQLQK RLQMFQIKKSDFMSALDTVMREEQNE*" /label="rnmV CDS" gene 49678..50238 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /label="rnmV gene" upshifts 49688 /Source="Nicolas_upshifts" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" CDS 50231..51109 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 99430, 6801425, 11327780, 1690648, 22391551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dimethyladenosine 16S ribosomal RNA transferase" /protein_id="NP_387923.1" /db_xref="EnsemblGenomes-Gn:BSU00420" /db_xref="EnsemblGenomes-Tr:CAB11818" /db_xref="GOA:P37468" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR011530" /db_xref="InterPro:IPR020596" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023165" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10105" /db_xref="UniProtKB/Swiss-Prot:P37468" /translation="MNKDIATPIRTKEILKKYGFSFKKSLGQNFLIDTNILNRIVDHA EVTEKTGVIEIGPGIGALTEQLAKRAKKVVAFEIDQRLLPILKDTLSPYENVTVIHQD VLKADVKSVIEEQFQDCDEIMVVANLPYYVTTPIIMKLLEEHLPLKGIVVMLQKEVAE RMAADPSSKEYGSLSIAVQFYTEAKTVMIVPKTVFVPQPNVDSAVIRLILRDGPAVDV ENESFFFQLIKASFAQRRKTLLNNLVNNLPEGKAQKSTIEQVLEETNIDGKRRGESLS IEEFAALSNGLYKALF*" /label="rsmA CDS" gene 50231..51109 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /label="rsmA gene" downshifts 51074 /Source="Nicolas_upshifts" /id="D18" /incds=0 /nref=152 /ntot=229 /MaxReadThrough="3.0815" /MaxDrop="4.58632" /score="20.4155562" /energy="-9.4" /TU="NA" /idTUdmin="U36" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 51124..51133 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 51147..51166 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 51149..51270 /Source="Nicolas_S_feature" /locus_tag="new_51558_51679" /HighExp="S7, S6, S8, BT, S5, B36, G/S, Pyr, B60, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S28" upshifts 51149 /Source="Nicolas_upshifts" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="upshifts" CDS 51271..52143 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 11040425, 16751597, 19060142, 19833771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 11040425, 16751597, 19060142, 19833771; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protease" /protein_id="NP_387924.1" /db_xref="EnsemblGenomes-Gn:BSU00430" /db_xref="EnsemblGenomes-Tr:CAB11819" /db_xref="GOA:P37548" /db_xref="InterPro:IPR008764" /db_xref="SubtiList:BG10106" /db_xref="UniProtKB/Swiss-Prot:P37548" /translation="MQFQIGDMVARKSYQMDVLFRIIGIEQTSKGNSIAILHGDEVRL IADSDFSDLVAVKKDEQMMRKKKDESRMNESLELLRQDYKLLREKQEYYATSQYQHQE HYFHMPGKVLHLDGDEAYLKKCLNVYKKIGVPVYGIHCHEKKMSASIEVLLDKYRPDI LVITGHDAYSKQKGGIDDLNAYRHSKHFVETVQTARKKIPHLDQLVIFAGACQSHFES LIRAGANFASSPSRVNIHALDPVYIVAKISFTPFMERINVWEVLRNTLTREKGLGGIE TRGVLRIGMPYKSN*" /label="prtG CDS" gene 51271..52143 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /label="prtG gene" downshifts 52130 /Source="Nicolas_upshifts" /id="D19" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.30424" /MaxDrop="7.1507" /score="26.6672651" /energy="-11.5" /TU="NA" /idTUdmin="U42" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 52240..52310 /Source="Nicolas_S_feature" /locus_tag="new_52649_52719" /HighExp="S8, S5, S7, S6, S4, BT, LoTm, G/S, nit, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S29" promotor_-35 52301..52308 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 52312 /Source="Nicolas_upshifts" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 52322..52341 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(52331..52345) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(52338) /Source="Nicolas_upshifts" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(52354..52358) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 52354..52614 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12761295, 22720735, 23378512; Producttype ph: phenotype" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387925.1" /db_xref="EnsemblGenomes-Gn:BSU00440" /db_xref="EnsemblGenomes-Tr:CAB11820" /db_xref="GOA:P37466" /db_xref="InterPro:IPR009366" /db_xref="SubtiList:BG10107" /db_xref="UniProtKB/Swiss-Prot:P37466" /translation="MAKTLSDIKRSLDGNLGKRLTLKANGGRRKTIERSGILAETYPS VFVIQLDQDENSFERVSYSYADILTETVELTFNDDAASSVAF*" /label="veg CDS" gene 52354..52614 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /label="veg gene" downshifts 52526 /Source="Nicolas_upshifts" /id="D20" /incds=1 /nref=4 /ntot=158 /MaxReadThrough="8.09861" /MaxDrop="2.7867" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U42" /TUdmin=396 /isTUend="FALSE" /label="downshifts" downshifts 52613 /Source="Nicolas_upshifts" /id="D21" /incds=0 /nref=191 /ntot=264 /MaxReadThrough="5.88511" /MaxDrop="6.03144" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U43" /TUdmin="-331" /isTUend="FALSE" /label="downshifts" promotor_-35 52679..52685 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 52699..52710 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 52702..52773 /Source="Nicolas_S_feature" /locus_tag="new_53111_53182" /HighExp="S8, Cold, S6, S7, ferm, S5, nit, Etha, G135, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S30" upshifts 52702 /Source="Nicolas_upshifts" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="upshifts" CDS 52774..52959 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7959056, 8982008, 11092849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7959056, 8982008, 11092849; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_387926.1" /db_xref="EnsemblGenomes-Gn:BSU00450" /db_xref="EnsemblGenomes-Tr:CAB11821" /db_xref="GOA:P37549" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10108" /db_xref="UniProtKB/Swiss-Prot:P37549" /translation="MGRRRGVMSDEFKYELAKDLGFYDTVKNGGWGEIRARDAGNMVK RAIEIAEQQMAQNQNNR*" /label="sspF CDS" gene 52774..52959 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /label="sspF gene" downshifts 52944 /Source="Nicolas_upshifts" /id="D22" /incds=0 /nref=54 /ntot=153 /MaxReadThrough="2.67408" /MaxDrop="6.21058" /score="38.1065567" /energy="-12.6" /TU="NA" /idTUdmin="U43" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(52954..55308) /Source="Nicolas_S_feature" /locus_tag="new_53363_55717_c" /HighExp="S5, S4, S6, T5.0H, S3, S8, S7, T4.0H, T3.30H, C30" /AntisenseName="ispE" /AntisenseCor="-0.66604185700913698" /AntisenseRegPval="-35.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S31" promotor_-35 53037..53041 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-35" promotor_-10 53057..53076 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-10" upshifts 53060 /Source="Nicolas_upshifts" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="upshifts" CDS 53107..53976 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /EC_number="2.7.1.148" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11361082, 12682299, 12771135, 17458547, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase" /protein_id="NP_387927.1" /db_xref="EnsemblGenomes-Gn:BSU00460" /db_xref="EnsemblGenomes-Tr:CAB11822" /db_xref="GOA:P37550" /db_xref="InterPro:IPR004424" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10109" /db_xref="UniProtKB/Swiss-Prot:P37550" /translation="MRILEKAPAKINLSLDVTRKRPDGYHEVEMIMTTIDLADRIELT ELAEDEVRVSSHNRFVPDDQRNLAYQAAKLIKDRYNVKKGVSIMITKVIPVAAGLAGG SSDAAATLRGLNRLWNLNLSAETLAELGAEIGSDVSFCVYGGTALATGRGEKIKHIST PPHCWVILAKPTIGVSTAEVYRALKLDGIEHPDVQGMIEAIEEKSFQKMCSRLGNVLE SVTLDMHPEVAMIKNQMKRFGADAVLMSGSGPTVFGLVQYESKVQRIYNGLRGFCDQV YAVRMIGEQNALD*" /label="ispE CDS" gene 53107..53976 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /label="ispE gene" CDS 54032..54889 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11591660, 12837783, 12837784, 15629952, 16163456, 27329548" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12837783, 12837784, 15629952, 16163456, 27329548; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine biosynthesis operon (PurR-pRpp)" /protein_id="NP_387928.1" /db_xref="EnsemblGenomes-Gn:BSU00470" /db_xref="EnsemblGenomes-Tr:CAB11823" /db_xref="GOA:P37551" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010078" /db_xref="InterPro:IPR015265" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1O57" /db_xref="PDB:1P4A" /db_xref="SubtiList:BG10110" /db_xref="UniProtKB/Swiss-Prot:P37551" /translation="MKFRRSGRLVDLTNYLLTHPHELIPLTFFSERYESAKSSISEDL TIIKQTFEQQGIGTLLTVPGAAGGVKYIPKMKQAEAEEFVQTLGQSLANPERILPGGY VYLTDILGKPSVLSKVGKLFASVFAEREIDVVMTVATKGIPLAYAAASYLNVPVVIVR KDNKVTEGSTVSINYVSGSSNRIQTMSLAKRSMKTGSNVLIIDDFMKAGGTINGMINL LDEFNANVAGIGVLVEAEGVDERLVDEYMSLLTLSTINMKEKSIEIQNGNFLRFFKDN LLKNGETES*" /label="purR CDS" gene 54032..54889 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /label="purR gene" CDS 54886..55263 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /EC_number="3.5.99.10" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2113912, 12515541, 14729707, 10557275, 10919400, 10368157, 20562306, 23815688; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminoacrylate/iminopropionate hydrolase/deaminase" /protein_id="NP_387929.1" /db_xref="EnsemblGenomes-Gn:BSU00480" /db_xref="EnsemblGenomes-Tr:CAB11824" /db_xref="GOA:P37552" /db_xref="InterPro:IPR006056" /db_xref="InterPro:IPR006175" /db_xref="InterPro:IPR019897" /db_xref="InterPro:IPR035959" /db_xref="PDB:1QD9" /db_xref="SubtiList:BG10111" /db_xref="UniProtKB/Swiss-Prot:P37552" /translation="MTKAVHTKHAPAAIGPYSQGIIVNNMFYSSGQIPLTPSGEMVNG DIKEQTHQVFSNLKAVLEEAGASFETVVKATVFIADMEQFAEVNEVYGQYFDTHKPAR SCVEVARLPKDALVEIEVIALVK*" /label="ridA CDS" gene 54886..55263 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /label="ridA gene" downshifts 55253 /Source="Nicolas_upshifts" /id="D23" /incds=0 /nref=172 /ntot=226 /MaxReadThrough="3.8891" /MaxDrop="4.63425" /score="22.9159767" /energy="-12.3" /TU="U46" /idTUdmin="U46" /TUdmin="-155" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(55297..55315) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 55298..55406 /Source="Nicolas_S_feature" /locus_tag="new_55707_55815" /HighExp="S8, S7, Etha, B36, LoTm, C30, Sw, B60, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S32" upshifts complement(55309) /Source="Nicolas_upshifts" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(55331..55336) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 55386..55394 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-35" promotor_-10 55405..55423 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-10" upshifts 55408 /Source="Nicolas_upshifts" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="upshifts" CDS 55457..55750 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733708, 10348850, 10648512, 16428420, 27048798" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733708, 10348850, 10648512, 16428420, 27048798; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for spore cortex synthesis (stage V sporulation)" /protein_id="NP_387930.1" /db_xref="EnsemblGenomes-Gn:BSU00490" /db_xref="EnsemblGenomes-Tr:CAB11825" /db_xref="GOA:P28015" /db_xref="InterPro:IPR007170" /db_xref="InterPro:IPR036751" /db_xref="PDB:2IA9" /db_xref="SubtiList:BG10112" /db_xref="UniProtKB/Swiss-Prot:P28015" /translation="MEVTDVRLRRVNTDGRMRAIASITLDHEFVVHDIRVIDGNNGLF VAMPSKRTPDGEFRDITHPINSSTRGKIQDAVLNEYHRLGDTEALEFEEAGAS*" /label="spoVG CDS" gene 55457..55750 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /label="spoVG gene" downshifts 55739 /Source="Nicolas_upshifts" /id="D24" /incds=0 /nref=263 /ntot=285 /MaxReadThrough="5.11673" /MaxDrop="7.2673" /score="19.392304" /energy="-22.3" /TU="U48" /idTUdmin="U46" /TUdmin=331 /isTUend="FALSE" /label="downshifts" S_feature 55784..55895 /Source="Nicolas_S_feature" /locus_tag="new_56193_56304" /HighExp="B60, B36, M9-stat, S2, BT, LoTm, Etha, Lbstat, T0.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S33" promotor_-35 55877..55881 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 55897..55916 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 55897 /Source="Nicolas_upshifts" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 55943..57313 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /EC_number="2.3.1.157" /EC_number="2.7.7.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional glucosamine-1-phosphate N-acetyltransferase/UDP-N-acetylglucosamine pyrophosphorylase" /protein_id="NP_387931.1" /db_xref="EnsemblGenomes-Gn:BSU00500" /db_xref="EnsemblGenomes-Tr:CAB11826" /db_xref="GOA:P14192" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005882" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10113" /db_xref="UniProtKB/Swiss-Prot:P14192" /translation="MDKRFAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDEALKL SLSKLVTIVGHGAEEVKKQLGDKSEYALQAKQLGTAHAVKQAQPFLADEKGVTIVICG DTPLLTAETMEQMLKEHTQREAKATILTAVAEDPTGYGRIIRSENGAVQKIVEHKDAS EEERLVTEINTGTYCFDNEALFRAIDQVSNDNAQGEYYLPDVIEILKNEGETVAAYQT GNFQETLGVNDRVALSQAEQFMKERINKRHMQNGVTLIDPMNTYISPDAVIGSDTVIY PGTVIKGEVQIGEDTIIGPHTEIMNSAIGSRTVIKQSVVNHSKVGNDVNIGPFAHIRP DSVIGNEVKIGNFVEIKKTQFGDRSKASHLSYVGDAEVGTDVNLGCGSITVNYDGKNK YLTKIEDGAFIGCNSNLVAPVTVGEGAYVAAGSTVTEDVPGKALAIARARQVNKDDYV KNIHKK*" /label="glmU CDS" gene 55943..57313 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /label="glmU gene" downshifts complement(57288) /Source="Nicolas_upshifts" /id="D25" /incds=0 /nref=5 /ntot=84 /MaxReadThrough="2.39379" /MaxDrop="3.65636" /score="-7.65702938" /energy="-13.8" /TU="NA" /idTUdmin="U47" /TUdmin="-4312" /isTUend="FALSE" /label="downshifts" CDS 57336..58289 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /EC_number="2.7.6.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2169413, 3038693, 8522540, 22083279, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2169413, 3038693, 8522540, 22083279, 25890046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylpyrophosphate synthetase" /protein_id="NP_387932.1" /db_xref="EnsemblGenomes-Gn:BSU00510" /db_xref="EnsemblGenomes-Tr:CAB11827" /db_xref="GOA:P14193" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR000842" /db_xref="InterPro:IPR005946" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR029099" /db_xref="PDB:1DKR" /db_xref="PDB:1DKU" /db_xref="PDB:1IBS" /db_xref="SubtiList:BG10114" /db_xref="UniProtKB/Swiss-Prot:P14193" /translation="MSNQYGDKNLKIFSLNSNPELAKEIADIVGVQLGKCSVTRFSDG EVQINIEESIRGCDCYIIQSTSDPVNEHIMELLIMVDALKRASAKTINIVIPYYGYAR QDRKARSREPITAKLFANLLETAGATRVIALDLHAPQIQGFFDIPIDHLMGVPILGEY FEGKNLEDIVIVSPDHGGVTRARKLADRLKAPIAIIDKRRPRPNVAEVMNIVGNIEGK TAILIDDIIDTAGTITLAANALVENGAKEVYACCTHPVLSGPAVERINNSTIKELVVT NSIKLPEEKKIERFKQLSVGPLLAEAIIRVHEQQSVSYLFS*" /label="prs CDS" gene 57336..58289 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /label="prs gene" promotor_-35 58302..58308 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 58321 /Source="Nicolas_upshifts" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 58323..58341 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 58374..58988 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8522540, 9669336, 10369900, 12432960, 17198710" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8522540, 9669336, 10369900, 12432960, 17198710; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein BL25 (Ctc), binding 5S RNA" /protein_id="NP_387933.1" /db_xref="EnsemblGenomes-Gn:BSU00520" /db_xref="EnsemblGenomes-Tr:CAB11828" /db_xref="GOA:P14194" /db_xref="InterPro:IPR001021" /db_xref="InterPro:IPR011035" /db_xref="InterPro:IPR020056" /db_xref="InterPro:IPR020057" /db_xref="InterPro:IPR029751" /db_xref="InterPro:IPR037121" /db_xref="SubtiList:BG10115" /db_xref="UniProtKB/Swiss-Prot:P14194" /translation="MATLTAKERTDFTRSSLRNIRTSGHVPGIIYGKDTGNKPVSLDS VELIKTLRDEGKNAVITLEVSGEKHSVMVTDLQTDPLKNEITHADFQVVNMSEDIEVE VPIHLTGEAIGVKNGGVLQQPLYALTVKAKPKAIPQTIEADISSLDVNEVLTIADLPA GGDYSFNHESDEVVASILPPQQQEAAEVDEEESADAQPEGENEQ*" /label="ctc CDS" gene 58374..58988 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /label="ctc gene" downshifts 58972 /Source="Nicolas_upshifts" /id="D26" /incds=0 /nref=120 /ntot=249 /MaxReadThrough="8.65206" /MaxDrop="5.4784" /score="1.94770319" /energy="-11.2" /TU="U49,U50" /idTUdmin="U48" /TUdmin=682 /isTUend="FALSE" /label="downshifts" CDS 59095..59661 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /EC_number="3.1.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8635758, 12100553, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8635758, 12100553, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-tRNA hydrolase" /protein_id="NP_387934.1" /db_xref="EnsemblGenomes-Gn:BSU00530" /db_xref="EnsemblGenomes-Tr:CAB11829" /db_xref="GOA:P37470" /db_xref="InterPro:IPR001328" /db_xref="InterPro:IPR018171" /db_xref="InterPro:IPR036416" /db_xref="SubtiList:BG10116" /db_xref="UniProtKB/Swiss-Prot:P37470" /translation="MLVIAGLGNPGKNYENTRHNVGFMVIDQLAKEWNIELNQNKFNG LYGTGFVSGKKVLLVKPLTYMNLSGECLRPLMDYYDVDNEDLTVIYDDLDLPTGKIRL RTKGSAGGHNGIKSLIQHLGTSEFDRIRIGIGRPVNGMKVVDYVLGSFTKEEAPEIEE AVDKSVKACEASLSKPFLEVMNEFNAKV*" /label="pth CDS" gene 59095..59661 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /label="pth gene" misc_feature 59274..59277 /Source="Nicolas_upshift_promotors" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 59280 /Source="Nicolas_upshifts" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 59721..59951 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /experiment="publication(s) with functional evidences, PMID:21037003, 28598017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21037003, 28598017; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein required for the switch from F to G during sporulation (anti sigma F)" /protein_id="NP_387935.1" /db_xref="EnsemblGenomes-Gn:BSU00540" /db_xref="EnsemblGenomes-Tr:CAB11830" /db_xref="GOA:P37553" /db_xref="InterPro:IPR020115" /db_xref="PDB:5MSL" /db_xref="SubtiList:BG10117" /db_xref="UniProtKB/Swiss-Prot:P37553" /translation="MALHYYCRHCGVKVGSLESSMVSTDSLGFQHLTNEERNDMISYK ENGDVHVLTICEDCQEALDRNPHYHEYHTFIQ*" /label="fin CDS" gene 59721..59951 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /label="fin gene" S_feature 59952..60020 /Source="Nicolas_S_feature" /locus_tag="new_60361_60429" /HighExp="Etha, S5, S4, S7, S8, S6, S3, H2O2, Diami, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigB, SigA" /TUshortPSig="0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S34" CDS 60021..63554 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription-repair coupling factor" /protein_id="NP_387936.1" /db_xref="EnsemblGenomes-Gn:BSU00550" /db_xref="EnsemblGenomes-Tr:CAB11831" /db_xref="GOA:P37474" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR004576" /db_xref="InterPro:IPR005118" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG10118" /db_xref="UniProtKB/Swiss-Prot:P37474" /translation="MDNIQTFIKESDDFKSIINGLHEGLKEQLLAGLSGSARSVFTSA LANETNKPIFLITHNLYQAQKVTDDLTSLLEDRSVLLYPVNELISSEIAVASPELRAQ RLDVINRLTNGEAPIVVAPVAAIRRMLPPVEVWKSSQMLIQVGHDIEPDQLASRLVEV GYERSDMVSAPGEFSIRGGIIDIYPLTSENPVRIELFDTEVDSIRSFNSDDQRSIETL TSINIGPAKELIIRPEEKARAMEKIDSGLAASLKKLKADKQKEILHANISHDKERLSE GQTDQELVKYLSYFYEKPASLLDYTPDNTLLILDEVSRIHEMEEQLQKEEAEFITNLL EEGKILHDIRLSFSFQKIVAEQKRPLLYYSLFLRHVHHTSPQNIVNVSGRQMQSFHGQ MNVLAGEMERFKKSNFTVVFLGANKERTQKLSSVLADYDIEAAMTDSKKALVQGQVYI MEGELQSGFELPLMKLAVITEEELFKNRVKKKPRKQKLTNAERIKSYSELQIGDYVVH INHGIGKYLGIETLEINGIHKDYLNIHYQGSDKLYVPVEQIDQVQKYVGSEGKEPKLY KLGGSEWKRVKKKVETSVQDIADDLIKLYAEREASKGYAFSPDHEMQREFESAFPYQE TEDQLRSIHEIKKDMERERPMDRLLCGDVGYGKTEVAIRAAFKAIGDGKQVALLVPTT ILAQQHYETIKERFQDYPINIGLLSRFRTRKEANETIKGLKNGTVDIVIGTHRLLSKD VVYKDLGLLIIDEEQRFGVTHKEKIKQIKANVDVLTLTATPIPRTLHMSMLGVRDLSV IETPPENRFPVQTYVVEYNGALVREAIERELARGGQVYFLYNRVEDIERKADEISMLV PDAKVAYAHGKMTENELETVMLSFLEGESDVLVSTTIIETGVDIPNVNTLIVFDADKM GLSQLYQLRGRVGRSNRVAYAYFTYRRDKVLTEVAEKRLQAIKEFTELGSGFKIAMRD LTIRGAGNLLGAQQHGFIDSVGFDLYSQMLKEAIEERKGDTAKTEQFETEIDVELDAY IPETYIQDGKQKIDMYKRFRSVATIEEKNELQDEMIDRFGNYPKEVEYLFTVAEMKVY ARQERVELIKQDKDAVRLTISEEASAEIDGQKLFELGNQYGRQIGLGMEGKKLKISIQ TKGRSADEWLDTVLGMLKGLKDVKKQTISST*" /label="mfd CDS" gene 60021..63554 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /label="mfd gene" promotor_-35 63572..63578 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 63592..63689 /Source="Nicolas_S_feature" /locus_tag="new_64001_64098" /HighExp="S5, S7, S8, S6, S4, Etha, S3, H2O2, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, Sig-, SigB, SigA" /TUshortPSig="1, 0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S35" promotor_-10 63592..63603 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 63592 /Source="Nicolas_upshifts" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 63690..64226 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of sporulation / germination" /protein_id="NP_387937.1" /db_xref="EnsemblGenomes-Gn:BSU00560" /db_xref="EnsemblGenomes-Tr:CAB11832" /db_xref="GOA:P37554" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR014213" /db_xref="PDB:2RO5" /db_xref="PDB:2W1R" /db_xref="PDB:2W1T" /db_xref="SubtiList:BG10119" /db_xref="UniProtKB/Swiss-Prot:P37554" /translation="MKATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEV ILKKYSPISELGDFAKEYADALYDSLGHSVLICDRDVYIAVSGSSKKDYLNKSISEML ERTMDQRSSVLESDAKSVQLVNGIDEDMNSYTVGPIVANGDPIGAVVIFSKDQTMGEV EHKAVETAAGFLARQMEQ*" /label="spoVT CDS" gene 63690..64226 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /label="spoVT gene" downshifts 64230 /Source="Nicolas_upshifts" /id="D27" /incds=0 /nref=236 /ntot=260 /MaxReadThrough="1.92082" /MaxDrop="6.20706" /score="-2.69593259" /energy="-11.6" /TU="NA" /idTUdmin="U49" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 64326..64345 /Source="Nicolas_upshift_promotors" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 64337 /Source="Nicolas_upshifts" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" CDS 64408..66006 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_387938.1" /db_xref="EnsemblGenomes-Gn:BSU00570" /db_xref="EnsemblGenomes-Tr:CAB11833" /db_xref="GOA:P37555" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10120" /db_xref="UniProtKB/Swiss-Prot:P37555" /translation="MDDSIGVKRHWIWQGAFVLILAGVITKILSAVYRVPFQNIVGDV GFYIYQQVYPFLGIAVMLSTSGFPVIISKLMNDYSEKNHHTILKISALFLSLIGILLF LCLYLGAVPIALFMGDSHLAVLIQVAAYAFLLFPFVALLRGGFQGRHEMLPSALSQMT EQFLRVAVLLGLSFWLVKKGASLYTAGAAAASGSLAGSLVALIILGFFWFKTKRDNQT DRQNENVITTKELTKKLLLYSVTICVSSLLLLFIQLVDALNLYALLSGGEASEEAKCL KGIYDRGQPLLQLGSVFAVSIATSLVPYISMAVKNKELKIMKEKITSSLKLCLVLGTG ASAGLICILKPVNIMLFQNGEGTGALQVFSCSILFASLAVTAAAVLQGAGYTVFPAIA VGAGVAVKWVLNTLLVPRYGIEGASLATAASFAAVAGLNLYQLRQKEWLDKLRGVLIP IIGSALLMSAVLLAYTRLWTFLFPATGRGAAVIESLSAVAIGGAVFIYCMMRLGIFTD EELNSVPFGSKLSKFMRRREQNGG*" /label="yabM CDS" gene 64408..66006 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /label="yabM gene" promotor_-35 65877..65884 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-35" promotor_-10 65899..65918 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-10" upshifts 65913 /Source="Nicolas_upshifts" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="upshifts" CDS 65996..67465 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11178267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fusion methylase and nucleotide pyrophosphohydrolase" /protein_id="NP_387939.1" /db_xref="EnsemblGenomes-Gn:BSU00580" /db_xref="EnsemblGenomes-Tr:CAB11834" /db_xref="GOA:P37556" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011551" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR024180" /db_xref="InterPro:IPR035013" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10121" /db_xref="UniProtKB/Swiss-Prot:P37556" /translation="MAGKITVVGLGAGDMDQLTIGIHKLLTKADTLYVRTKDHPLIEE LEKETKNIRFFDDIYEKHDQFEAVYEEIADILFEAARREDVVYAVPGHPFVAEKTVQL LTERQEKENVQVKVAGGQSFLDATFNVLQIDPIEGFQFVDAGTLSADELELRHHLIIC QVYDQMTASEVKLTLMEKLPDDYEVVIVTAAGSRGEEIRTVPLFELDRNVALNNLTSV YIPPIKEEKLLYHEFSTFRSIIRELRGPNGCPWDKKQTHQSLKQYMIEECYELLEAID EEDTDHMIEELGDVLLQVLLHAQIGEDEGYFTIDDVIKGISEKMVRRHPHVFKDVKVQ DENDVLANWEDIKKAEKNTSESSLLDSVPKTLPALSKAAKLQKKAAKVGFDWEDVSDI WEKVSEEMKEFSSEVSEAPHEHNLKAEFGDILFALVNVARFYKIEPEEALTMTNDKFR RRFSYIEETAKEEGVELADMSLEDMDKLWNEAKETERRS*" /label="yabN CDS" gene 65996..67465 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /label="yabN gene" promotor_-35 66637..66644 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-35" promotor_-10 66658..66676 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-10" upshifts 66672 /Source="Nicolas_upshifts" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="upshifts" promotor_no_box complement(67060..67160) /Source="Nicolas_upshift_promotors" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(67100) /Source="Nicolas_upshifts" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 67468..67728 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10675343, 10675344, 19013177; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal RNA binding protein involved in 50S recycling; heat shock protein" /protein_id="NP_387940.1" /db_xref="EnsemblGenomes-Gn:BSU00590" /db_xref="EnsemblGenomes-Tr:CAB11835" /db_xref="GOA:P37557" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR025490" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10122" /db_xref="UniProtKB/Swiss-Prot:P37557" /translation="MRLDKFLKVSRLIKRRTLAKEVADQGRISINGNQAKASSDVKPG DELTVRFGQKLVTVQVNELKDTTKKEEAANMYTILKEEKLGE*" /label="hslR CDS" gene 67468..67728 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /label="hslR gene" promotor_-35 67733..67738 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 67754..67772 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 67772 /Source="Nicolas_upshifts" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(67804) /Source="Nicolas_upshifts" /id="D28" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="1.93659" /MaxDrop="3.17193" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=3014 /isTUend="FALSE" /label="downshifts" CDS 67807..68109 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15231775, 21904870, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15231775, 21904870, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore protein involved in the shaping of the spore coat" /protein_id="NP_387941.1" /db_xref="EnsemblGenomes-Gn:BSU00600" /db_xref="EnsemblGenomes-Tr:CAB11836" /db_xref="GOA:P37558" /db_xref="InterPro:IPR012504" /db_xref="InterPro:IPR022476" /db_xref="SubtiList:BG10123" /db_xref="UniProtKB/Swiss-Prot:P37558" /translation="MNSYYDQKGSSSVPEQHDVTMKGRKHLDISGVKHVESFDNEEFL LETVMGMLSVRGQNLQMKNLDVEKGIVSIKGRVFDLVYLDEQQGDKAKGFFSKLFK*" /label="spcP CDS" gene 67807..68109 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /label="spcP gene" CDS 68106..68741 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein of the forespore" /protein_id="NP_387942.1" /db_xref="EnsemblGenomes-Gn:BSU00610" /db_xref="EnsemblGenomes-Tr:CAB11837" /db_xref="GOA:P37559" /db_xref="InterPro:IPR014242" /db_xref="InterPro:IPR019074" /db_xref="SubtiList:BG10124" /db_xref="UniProtKB/Swiss-Prot:P37559" /translation="MTLTTQFYTMLAMSGMGLWLGASLDTYRLFVIRAKTARWLLFIH DILFWIMQGLLFFYVLLHVNEGEFRIYIFLAVLLGVATYQSLCKRIYIKILKFVIYLV VSVYQFFKKLIQHVLFRPIVWTCGAIIWLAAFLFKKTYSLIGFLLLCLYKIVMVLCFP IRFIAKQCLKLLPVKMRLTFRRYFEKGAGFLKKKKKLLITIRTTITRFLKR*" /label="spcQ CDS" gene 68106..68741 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /label="spcQ gene" promotor_-35 68611..68620 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68633..68648 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68635 /Source="Nicolas_upshifts" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 68667..68675 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68686..68704 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68696 /Source="Nicolas_upshifts" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" CDS 68759..69136 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_387943.1" /db_xref="EnsemblGenomes-Gn:BSU00620" /db_xref="EnsemblGenomes-Tr:CAB11838" /db_xref="GOA:P37471" /db_xref="InterPro:IPR007060" /db_xref="SubtiList:BG10125" /db_xref="UniProtKB/Swiss-Prot:P37471" /translation="MNFSRERTITEIQNDYKEQVERQNQLKKRRRKGLYRRLTVFGAL VFLTAIVLASSVWSQTSSLSAKEEKKEQLEKELKSLKTKQTDLKEEISKLKDEDYVTE LARRDLFMSGDGEIIFNVEKKSK*" /label="divIC CDS" gene 68759..69136 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /label="divIC gene" CDS 69217..69603 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 15066026, 16014871, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; polyribonucleotide nucleotidyltransferase or phosphorylase" /protein_id="NP_387944.1" /db_xref="EnsemblGenomes-Gn:BSU00630" /db_xref="EnsemblGenomes-Tr:CAB11839" /db_xref="GOA:P37560" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG10126" /db_xref="UniProtKB/Swiss-Prot:P37560" /translation="MSIEVGSKLQGKITGITNFGAFVELPGGSTGLVHISEVADNYVK DINDHLKVGDQVEVKVINVEKDGKIGLSIKKAKDRPQARPRNDFRPKESFEQKMNKFL KDSEDRLSSLKRNTESKRGGRGARRG*" /label="yabR CDS" gene 69217..69603 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /label="yabR gene" downshifts 69597 /Source="Nicolas_upshifts" /id="D29" /incds=0 /nref=247 /ntot=274 /MaxReadThrough="3.67278" /MaxDrop="8.3221" /score="23.2738869" /energy="-12.5" /TU="U58" /idTUdmin="U53" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 69711..69718 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 69732..69751 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 69747 /Source="Nicolas_upshifts" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="upshifts" tRNA 69772..69848 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="methionine transfer RNA (CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Met1 tRNA" gene 69772..69848 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /label="trnSL-Met1 gene" tRNA 69858..69929 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="glutamate transfer RNA (UUC); Evidence 2a: Functionfrom experimental evidences in other organisms; Producttype n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Glu1 tRNA" gene 69858..69929 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /label="trnSL-Glu1 gene" downshifts 69928 /Source="Nicolas_upshifts" /id="D30" /incds=0 /nref=2 /ntot=58 /MaxReadThrough="4.83761" /MaxDrop="5.55326" /score="25.2769629" /energy="-10.8" /TU="U58,U60" /idTUdmin="U58" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 69973..70084 /Source="Nicolas_S_feature" /locus_tag="new_70382_70493" /HighExp="Cold, G180, C30, G135, G150, Oxctl, Paraq, H2O2, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S36" misc_feature 70080..70099 /Source="Nicolas_upshift_promotors" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 70086 /Source="Nicolas_upshifts" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="upshifts" CDS 70129..72612 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /EC_number="3.1.3.16" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10747015, 12180929, 15126482, 15866939, 15978076, 28358838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10747015, 12180929, 15126482, 15866939, 15978076, 28358838; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="SpoIIAA-phosphate serine phosphatase" /protein_id="NP_387945.1" /db_xref="EnsemblGenomes-Gn:BSU00640" /db_xref="EnsemblGenomes-Tr:CAB11840" /db_xref="GOA:P37475" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014221" /db_xref="InterPro:IPR036457" /db_xref="PDB:3T91" /db_xref="PDB:3T9Q" /db_xref="PDB:5UCG" /db_xref="SubtiList:BG10127" /db_xref="UniProtKB/Swiss-Prot:P37475" /translation="MEKAERRVNGPMAGQALEKLQSFFNRGTKLVTHHLHSLFFYKGF IYVVIGFLLGRAFILSEVLPFALPFFGAMLLIRRDKAFYAVLAVLAGALTISPKHSLL ILAALLAFFVFSKVAAFITDDRVKALPIVVFFSMAAARAGFVYAQNGVFTTYDYVMAI VEAGLSFILTLIFLQSLPIFTVKKVKQSLKIEEIICFMILIASVLTGLAGLSYQGMQA EHILARYVVLSFSFIGGASIGCTVGVVTGLILGLANIGNLYQMSLLAFSGLLGGLLKE GKKAGAAIGLIVGSLLISLYGEGSAGLMTTLYESLIAVCLFLLTPQSITRKVARYIPG TVEHLQEQQQYARKIRDVTAQKVDQFSNVFHALSESFATFYQASDEQTDDSEVDLFLS KITEHSCQTCYKKNRCWVQNFDKTYDLMKQVMLETEEKEYASNRRLKKEFQQYCSKSK QVEELIEDELAHHHAHLTLKKKVQDSRRLVAEQLLGVSEVMADFSREIKREREQHFLQ EEQIIEALQHFGIEIQHVEIYSLEQGNIDIEMTIPFSGHGESEKIIAPMLSDILEEQI LVKAEQHSPHPNGYSHVAFGSTKSYRVSTGAAHAAKGGGLVSGDSYSMMELGARKYAA AISDGMGNGARAHFESNETIKLLEKILESGIDEKIAIKTINSILSLRTTDEIYSTLDL SIIDLQDASCKFLKVGSTPSFIKRGDQVMKVQASNLPIGIINEFDVEVVSEQLKAGDL LIMMSDGIFEGPKHVENHDLWMKRKMKGLKTNDPQEIADLLMEEVIRTRSGQIEDDMT VVVVRIDHNTPKWASIPVPAIFQNKQEIS*" /label="spoIIE CDS" gene 70129..72612 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /label="spoIIE gene" downshifts 70170 /Source="Nicolas_upshifts" /id="D31" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="5.5737" /MaxDrop="3.93473" /score="25.2769629" /energy="-10.8" /TU="U60,U61" /idTUdmin="U58" /TUdmin=44 /isTUend="FALSE" /label="downshifts" S_feature complement(70781..71390) /Source="Nicolas_S_feature" /locus_tag="new_71190_71799_c" /HighExp="S8, S6, S4, S5, S3, S7, M9-stat, T5.0H, LoTm, Pyr" /AntisenseName="spoIIE" /AntisenseCor="0.685558251745638" /AntisenseRegPval="-38" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S37" downshifts complement(70807) /Source="Nicolas_upshifts" /id="D32" /incds=1 /nref=2 /ntot=11 /MaxReadThrough="2.2425" /MaxDrop="4.29972" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=11 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(71363..71381) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(71389) /Source="Nicolas_upshifts" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(71397..71402) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 71594..71600 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 71615..71633 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 71622 /Source="Nicolas_upshifts" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 72632..72635 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 72653..72670 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 72656 /Source="Nicolas_upshifts" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="upshifts" CDS 72697..73434 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387946.1" /db_xref="EnsemblGenomes-Gn:BSU00650" /db_xref="EnsemblGenomes-Tr:CAB11841" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG10128" /db_xref="UniProtKB/Swiss-Prot:P37561" /translation="MNNGHLNQILLITDGCSNHGEDPLAMAAFAKEQGITVNVIGIME ENQIDPEAMKEVEGIALAGGGVHQVVYASQLSQTVQMVTKKAMTQTLQGVVNQELKQI LGKNVEMEELSPEKRGEVMEVVDELGETVHLQVLVLVDTSASMAPKLPTVKEALIDLS VSLNSRIGNNEFAMCIFPGKKQEVELVLNWTPKLQSLSTLFAKLSTGGITPTGPAIRE ATLQFEKIRSRRGMLADDERRFDEFGM*" /label="yabS CDS" gene 72697..73434 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /label="yabS gene" CDS 73400..74416 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23634894, 24731262, 25278935" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23634894, 24731262, 25278935; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine-protein kinase" /protein_id="NP_387947.2" /db_xref="EnsemblGenomes-Gn:BSU00660" /db_xref="EnsemblGenomes-Tr:CAB11842" /db_xref="GOA:P37562" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG10129" /db_xref="UniProtKB/Swiss-Prot:P37562" /translation="MMNDALTSLACSLKPGTTIKGKWNGNTYTLRKQLGKGANGIVYL AETSDGHVALKVSDDSLSITSEVNVLKSFSKAQSVTMGPSFFDTDDAYIPSANTKVSF YAMEYIKGPLLLKYVSDKGAEWIPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPP ARIRCIDVGGTTKEGRAIKEYTEFYDRGYWGYGTRKAEPSYDLFAVAMIMINSVHKKE FKKTNQPKEQLRSLIEGNPLLQKYKKALFSALNGDYQSADEMKKDMLDAGQKAAQRKQ PIKASPQPATRQRQQKPRQGKITKTRYTPKQKPAKSGGLFETTLIVISVLALYFAYII FFLI*" /label="prkT CDS" gene 73400..74416 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /label="prkT gene" promotor_-35 73948..73954 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-35" promotor_-10 73970..73988 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-10" upshifts 73976 /Source="Nicolas_upshifts" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="upshifts" promotor_-35 74446..74453 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 74467..74486 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 74477 /Source="Nicolas_upshifts" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 74520..75938 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /EC_number="6.3.4.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14527414, 16039592, 17005971, 22720735, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14527414, 16039592, 17005971, 22720735, 24001521; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(ile2) lysidine synthetase" /protein_id="NP_387948.1" /db_xref="EnsemblGenomes-Gn:BSU00670" /db_xref="EnsemblGenomes-Tr:CAB11843" /db_xref="GOA:P37563" /db_xref="InterPro:IPR011063" /db_xref="InterPro:IPR012094" /db_xref="InterPro:IPR012795" /db_xref="InterPro:IPR012796" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015262" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG10130" /db_xref="UniProtKB/Swiss-Prot:P37563" /translation="MKSVKDFLNKHNLTLKGATIIVGVSGGPDSMALLHALHTLCGRS ANVIAAHVDHRFRGAESEEDMRFVQAYCKAEQLVCETAQINVTAYAQEKGLNKQAAAR DCRYQFFEEIMSKHQADYLALAHHGDDQVETMLMKLAKGTLGTGLAGMQPVRRFGTGR IIRPFLTITKEEILHYCHENGLSYRTDESNAKDDYTRNRFRKTVLPFLKQESPDVHKR FQKVSEALTEDEQFLQSLTKDEMNKVITSQSNTSVEINSSQLLALPMPLQRRGVQLIL NYLYENVPSSFSAHHIQQFLDWAENGGPSGVLDFPKGLKVVKSYQTCLFTFEQWQCKN VPFEYQISGAADETAVLPNGYLIEARHYADSPEEHGNAVFITSEKKVRFPLTIRTRKA GDRIKLKGMNGSKKVKDIFIDKKLPLQERDNWPIVTDASGEIIWIPGLKKSIFEDLVI PNSDRIVLQYRQHEKCRGQAKS*" /label="tilS CDS" gene 74520..75938 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /label="tilS gene" promotor_-35 75315..75322 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 75337..75356 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 75340 /Source="Nicolas_upshifts" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" downshifts complement(75933) /Source="Nicolas_upshifts" /id="D33" /incds=0 /nref=2 /ntot=142 /MaxReadThrough="2.51342" /MaxDrop="2.96272" /score="12.3455896" /energy="-9.1" /TU="NA" /idTUdmin="U68" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS 75935..76477 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /EC_number="2.4.2.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3110131, 6408059, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 6408059, 24001521; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hypoxanthine-guanine phosphoribosyltransferase" /protein_id="NP_387949.1" /db_xref="EnsemblGenomes-Gn:BSU00680" /db_xref="EnsemblGenomes-Tr:CAB11844" /db_xref="GOA:P37472" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005904" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10131" /db_xref="UniProtKB/Swiss-Prot:P37472" /translation="MMKHDIEKVLISEEEIQKKVKELGAELTSEYQDTFPLAIGVLKG ALPFMADLIKHIDTYLEMDFMDVSSYGNSTVSSGEVKIIKDLDTSVEGRDILIIEDII DSGLTLSYLVELFRYRKAKSIKIVTLLDKPSGRKADIKADFVGFEVPDAFVVGYGLDY AERYRNLPYIGVLKPAVYES*" /label="hprT CDS" gene 75935..76477 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /label="hprT gene" upshifts complement(76340) /Source="Nicolas_upshifts" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(76342..76346) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(76364..76367) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 76478..76574 /Source="Nicolas_S_feature" /locus_tag="new_76887_76983" /HighExp="Diami, H2O2, dia5, G135, dia15, G150, Paraq, C90, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.999, 1, 0.842" /TUlongSig="SigB, SigA" /TUlongPSig="1, 0.99" /label="S38" CDS 76575..78488 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /EC_number="3.4.24.-" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent cytoplasmic membrane protease" /protein_id="NP_387950.1" /db_xref="EnsemblGenomes-Gn:BSU00690" /db_xref="EnsemblGenomes-Tr:CAB11845" /db_xref="GOA:P37476" /db_xref="InterPro:IPR000642" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR003960" /db_xref="InterPro:IPR005936" /db_xref="InterPro:IPR011546" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR037219" /db_xref="SubtiList:BG10132" /db_xref="UniProtKB/Swiss-Prot:P37476" /translation="MNRVFRNTIFYLLILLVVIGVVSYFQTSNPKTENMSYSTFIKNL DDGKVDSVSVQPVRGVYEVKGQLKNYDKDQYFLTHVPEGKGADQIFNALKKTDVKVEP AQETSGWVTFLTTIIPFVIIFILFFFLLNQAQGGGSRVMNFGKSKAKLYTEEKKRVKF KDVAGADEEKQELVEVVEFLKDPRKFAELGARIPKGVLLVGPPGTGKTLLAKACAGEA GVPFFSISGSDFVEMFVGVGASRVRDLFENAKKNAPCLIFIDEIDAVGRQRGAGLGGG HDEREQTLNQLLVEMDGFSANEGIIIIAATNRADILDPALLRPGRFDRQITVDRPDVI GREAVLKVHARNKPLDETVNLKSIAMRTPGFSGADLENLLNEAALVAARQNKKKIDAR DIDEATDRVIAGPAKKSRVISKKERNIVAYHEGGHTVIGLVLDEADMVHKVTIVPRGQ AGGYAVMLPREDRYFQTKPELLDKIVGLLGGRVAEEIIFGEVSTGAHNDFQRATNIAR RMVTEFGMSEKLGPLQFGQSQGGQVFLGRDFNNEQNYSDQIAYEIDQEIQRIIKECYE RAKQILTENRDKLELIAQTLLKVETLDAEQIKHLIDHGTLPERNFSDDEKNDDVKVNI LTKTEEKKDDTKE*" /label="ftsH CDS" gene 76575..78488 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /label="ftsH gene" downshifts 78486 /Source="Nicolas_upshifts" /id="D34" /incds=0 /nref=187 /ntot=269 /MaxReadThrough="5.00908" /MaxDrop="8.91482" /score="38.4132386" /energy="-12.9" /TU="U66,U67" /idTUdmin="U64" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(78525..78529) /Source="Nicolas_upshift_promotors" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 78531..78616 /Source="Nicolas_S_feature" /locus_tag="new_78940_79025" /HighExp="H2O2, G180, G135, dia15, Paraq, G150, Oxctl, Diami, Cold, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S39" upshifts complement(78533) /Source="Nicolas_upshifts" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 78593..78600 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 78614..78633 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" S_feature 78618..78682 /Source="Nicolas_S_feature" /locus_tag="new_79027_79091" /HighExp="dia5, H2O2, dia15, Paraq, Diami, G180, LBGexp, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S40" upshifts 78618 /Source="Nicolas_upshifts" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 78683..79459 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15795230, 16905099, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15795230, 16905099, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase type III" /protein_id="NP_387951.2" /db_xref="EnsemblGenomes-Gn:BSU00700" /db_xref="EnsemblGenomes-Tr:CAB11846" /db_xref="GOA:P37564" /db_xref="InterPro:IPR004619" /db_xref="SubtiList:BG10133" /db_xref="UniProtKB/Swiss-Prot:P37564" /translation="MLLVIDVGNTNTVLGVYHDGKLEYHWRIETSRHKTEDEFGMILR SLFDHSGLMFEQIDGIIISSVVPPIMFALERMCTKYFHIEPQIVGPGMKTGLNIKYDN PKEVGADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTEA LYSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVI ATGGLAPLIANESDCIDIVDPFLTLKGLELIYERNRVGSV*" /label="coaX CDS" gene 78683..79459 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /label="coaX gene" CDS 79471..80346 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11323724, 15023991; Product type f: factor" /codon_start=1 /transl_table=11 /product="disulfide bond chaperone (heat shock protein HSP33)" /protein_id="NP_387952.1" /db_xref="EnsemblGenomes-Gn:BSU00710" /db_xref="EnsemblGenomes-Tr:CAB11847" /db_xref="GOA:P37565" /db_xref="InterPro:IPR000397" /db_xref="InterPro:IPR016153" /db_xref="InterPro:IPR016154" /db_xref="PDB:1VZY" /db_xref="SubtiList:BG10134" /db_xref="UniProtKB/Swiss-Prot:P37565" /translation="MDYLVKALAYDGKVRAYAARTTDMVNEGQRRHGTWPTASAALGR TMTASLMLGAMLKGDDKLTVKIEGGGPIGAIVADANAKGEVRAYVSNPQVHFDLNEQG KLDVRRAVGTNGTLSVVKDLGLREFFTGQVEIVSGELGDDFTYYLVSSEQVPSSVGVG VLVNPDNTILAAGGFIIQLMPGTDDETITKIEQRLSQVEPISKLIQKGLTPEEILEEV LGEKPEILETMPVRFHCPCSKERFETAILGLGKKEIQDMIEEDGQAEAVCHFCNEKYL FTKEELEGLRDQTTR*" /label="hslO CDS" gene 79471..80346 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /label="hslO gene" CDS 80393..81286 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 15856219; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein chaperone accessory lipoproteinfactor" /protein_id="NP_387953.1" /db_xref="EnsemblGenomes-Gn:BSU00720" /db_xref="EnsemblGenomes-Tr:CAB11848" /db_xref="GOA:P37566" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR027304" /db_xref="SubtiList:BG10135" /db_xref="UniProtKB/Swiss-Prot:P37566" /translation="MKSRTIWTIILGALLVCCIAVAYTLTKSQAGASSSGESIATIGG KSVTREEWLKEMEDQYGKSTLEDMINVRVVEQLAKKNKLKISKSEVDREFLLIKAVNN SFYEDEHTTEKEWKDQIRYNILLEDLLTRDIDISNKELESFYNKNKELYQFDDSYRIR HIVVKDEEEAREVLKELKGGSSFEAVAAERSTDRYTSPYGGDLGFVTEASDNIPSAYI EEAKTLKEDEWSQEPIKVSNGYAIIQLKEKLKARTFSFDEVKDQIRRQIAMDQLGDKA TVKTLWKEADVSWFYGEKSTK*" /label="yacD CDS" gene 80393..81286 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /label="yacD gene" promotor_-35 81016..81021 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 81038..81056 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 81039 /Source="Nicolas_upshifts" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 81285..81292 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 81307..81326 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 81314 /Source="Nicolas_upshifts" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 81362..82288 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /EC_number="2.5.1.47" /EC_number="4.4.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 15760717, 16267287, 16513748, 17056751, 18974048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15760717, 16267287, 16513748, 17056751, 18974048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cysteine synthase" /protein_id="NP_387954.1" /db_xref="EnsemblGenomes-Gn:BSU00730" /db_xref="EnsemblGenomes-Tr:CAB11849" /db_xref="GOA:P37887" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10136" /db_xref="UniProtKB/Swiss-Prot:P37887" /translation="MVRVANSITELIGNTPIVKLNRLADENSADVYLKLEYMNPGSSV KDRIGLAMIEAAEKEGKLKAGNTIIEPTSGNTGIGLAMVAAAKGLKAILVMPDTMSME RRNLLRAYGAELVLTPGAEGMKGAIKKAEELAEKHGYFVPQQFNNPSNPEIHRQTTGK EIVEQFGDDQLDAFVAGIGTGGTITGAGEVLKEAYPSIKIYAVEPSDSPVLSGGKPGP HKIQGIGAGFVPDILNTEVYDEIFPVKNEEAFEYARRAAREEGILGGISSGAAIYAAL QVAKKLGKGKKVLAIIPSNGERYLSTPLYQFD*" /label="cysK CDS" gene 81362..82288 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /label="cysK gene" downshifts 82281 /Source="Nicolas_upshifts" /id="D35" /incds=0 /nref=156 /ntot=259 /MaxReadThrough="5.90023" /MaxDrop="5.38596" /score="41.7897705" /energy="-11.4" /TU="U72" /idTUdmin="U70" /TUdmin=10 /isTUend="TRUE" /label="downshifts" promotor_-35 82335..82343 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 82357..82365 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 82359 /Source="Nicolas_upshifts" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 82387..82390 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 82405..82424 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 82415 /Source="Nicolas_upshifts" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="upshifts" CDS 82455..83867 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /EC_number="2.6.1.85" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 9084182, 16605270, 17114263, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase (para-aminobenzoate synthase)" /protein_id="NP_387955.1" /db_xref="EnsemblGenomes-Gn:BSU00740" /db_xref="EnsemblGenomes-Tr:CAB11850" /db_xref="GOA:P28820" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10137" /db_xref="UniProtKB/Swiss-Prot:P28820" /translation="MAQRRPAGKKIPFQKDSFLQQFEKLAQSRKHHVLLESARGGRYS IAGLDPIATVKGKDGITTIKHGDEMLFKEGDPLRAFHSWFKTLETETNHEFPDFQGGA IGFLSYDYARYIENFKMLSLDDLETPDIYFLVFDDIAVYDHQEESLWLITHVNGSDQE TADVKLSELEQMWLTELPAVTSREMKPETAGSFAAPFTEDGFSQAVEKIKQYIASGDV FQVNLSIRQSQSLSVHPYQIYKTLREVNPSPYMAYLETPDFQIICGSPELLVSKKGKL LETRPIAGTRSRGKTNEEDEALANELIHNEKERAEHVMLVDLERNDLGRVSRYGSVRV NEFMAIEKYSHVMHIVSNVQGELQDGYDAVDIIHAVFPGGTITGAPKVRTMEIIEELE PTRRGLYTGSIGWFGYNHDLQFNIVIRTIYATGGQAFMQSGAGVVIDSVPKHEYKESF KKAFAMQRALELSEEETKIR*" /label="pabB CDS" gene 82455..83867 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /label="pabB gene" promotor_-35 83257..83259 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 83277..83295 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 83283 /Source="Nicolas_upshifts" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 83624..83631 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 83644..83663 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 83657 /Source="Nicolas_upshifts" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="upshifts" CDS 83881..84465 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /EC_number="2.6.1.85" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098056, 16605270, 17114263, 24847778; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase; anthranilatesynthase (subunit II)" /protein_id="NP_387956.1" /db_xref="EnsemblGenomes-Gn:BSU00750" /db_xref="EnsemblGenomes-Tr:CAB11851" /db_xref="GOA:P28819" /db_xref="InterPro:IPR006221" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10138" /db_xref="UniProtKB/Swiss-Prot:P28819" /translation="MILMIDNYDSFTYNLVQYLGELGEELVVKRNDSITIDEIEELSP DFLMISPGPCSPDEAGISLEAIKHFAGKIPIFGVCLGHQSIAQVFGGDVVRAERLMHG KTSDIEHDGKTIFEGLKNPLVATRYHSLIVKPETLPSCFTVTAQTKEGEIMAIRHNDL PIEGVQFHPESIMTSFGKEMLRNFIETYRKEVIA*" /label="pabA CDS" gene 83881..84465 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /label="pabA gene" CDS 84465..85346 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /EC_number="4.1.3.38" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10876155, 1644759, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate pyruvate-lyase" /protein_id="NP_387957.1" /db_xref="EnsemblGenomes-Gn:BSU00760" /db_xref="EnsemblGenomes-Tr:CAB11852" /db_xref="GOA:P28821" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR017824" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10139" /db_xref="UniProtKB/Swiss-Prot:P28821" /translation="MIYVNGRYMEEKDAVLSPFDHGFLYGIGVFETFRLYEGCPFLLD WHIERLERALKDLQIEYTVSKHEILEMLDKLLKLNDIKDGNARVRLNISAGISDKGFV AQTYDKPTVLCFVNQLKPESLPLQKEGKVLSIRRNTPEGSFRLKSHHYLNNMYAKREI GNDPRVEGIFLTEDGAVAEGIISNVFWRKGRCIYTPSLDTGILDGVTRRFIIENAKDI GLELKTGRYELEALLTADEAWMTNSVLEIIPFTKIEEVNYGSQSGEATSALQLLYKKE IKNMIHEKGGRAWRSTQ*" /label="pabC CDS" gene 84465..85346 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /label="pabC gene" CDS 85328..86185 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /EC_number="2.5.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 11007651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydropteroate synthase" /protein_id="NP_387958.1" /db_xref="EnsemblGenomes-Gn:BSU00770" /db_xref="EnsemblGenomes-Tr:CAB11853" /db_xref="GOA:P28822" /db_xref="InterPro:IPR000489" /db_xref="InterPro:IPR006390" /db_xref="InterPro:IPR011005" /db_xref="SubtiList:BG10140" /db_xref="UniProtKB/Swiss-Prot:P28822" /translation="MAQHTIDQTQVIHTKPSALSYKEKTLVMGILNVTPDSFSDGGKY DSLDKALLHAKEMIDDGAHIIDIGGESTRPGAECVSEDEEMSRVIPVIERITKELGVP ISVDTYKASVADEAVKAGASIINDIWGAKHDPKMASVAAEHNVPIVLMHNRPERNYND LLPDMLSDLMESVKIAVEAGVDEKNIILDPGIGFAKTYHDNLAVMNKLEIFSGLGYPV LLATSRKRFIGRVLDLPPEERAEGTGATVCLGIQKGCDIVRVHDVKQIARMAKMMDAM LNKGGVHHG*" /label="folP CDS" gene 85328..86185 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /label="folP gene" CDS 86178..86540 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /EC_number="4.1.2.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16188473, 17176045, 17388809; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroneopterin aldolase" /protein_id="NP_387959.1" /db_xref="EnsemblGenomes-Gn:BSU00780" /db_xref="EnsemblGenomes-Tr:CAB11854" /db_xref="GOA:P28823" /db_xref="InterPro:IPR006156" /db_xref="InterPro:IPR006157" /db_xref="SubtiList:BG10141" /db_xref="UniProtKB/Swiss-Prot:P28823" /translation="MDKVYVEGMEFYGYHGVFTEENKLGQRFKVDLTAELDLSKAGQT DDLEQTINYAELYHVCKDIVEGEPVKLVETLAERIAGTVLGKFQPVQQCTVKVIKPDP PIPGHYKSVAIEITRKKS*" /label="folB CDS" gene 86178..86540 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /label="folB gene" CDS 86537..87040 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /EC_number="2.7.6.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17029412; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase" /protein_id="NP_387960.1" /db_xref="EnsemblGenomes-Gn:BSU00790" /db_xref="EnsemblGenomes-Tr:CAB11855" /db_xref="GOA:P29252" /db_xref="InterPro:IPR000550" /db_xref="InterPro:IPR035907" /db_xref="SubtiList:BG10142" /db_xref="UniProtKB/Swiss-Prot:P29252" /translation="MNNIAYIALGSNIGDRETYLRQAVALLHQHAAVTVTKVSSIYET DPVGYEDQAQFLNMAVEIKTSLNPFELLELTQQIENELGRTREVRWGPRTADLDILLF NRENIETEQLIVPHPRMYERLFVLAPLAEICQQVEKEATSAETDQEGVRVWKQKSGVD EFVHSES*" /label="folK CDS" gene 86537..87040 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /label="folK gene" CDS 86992..87201 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_387961.1" /db_xref="EnsemblGenomes-Gn:BSU00800" /db_xref="EnsemblGenomes-Tr:CAB11856" /db_xref="GOA:O31417" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG12701" /db_xref="UniProtKB/Swiss-Prot:O31417" /translation="MEAEIWGRRIRAFRKLKGYTQEGFAKALGISVSILGEIERGNRL PSAAIIQDAADVLNISADELAPPEK*" /label="yazB CDS" gene 86992..87201 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /label="yazB gene" CDS 87225..88226 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 15698474, 26112661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase B" /protein_id="NP_387962.1" /db_xref="EnsemblGenomes-Gn:BSU00810" /db_xref="EnsemblGenomes-Tr:CAB11857" /db_xref="GOA:P37567" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR004652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG10143" /db_xref="UniProtKB/Swiss-Prot:P37567" /translation="MFKIGDIQLKNRVVLAPMAGVCNSAFRLTVKEFGAGLVCAEMVS DKAILYNNARTMGMLYIDEREKPLSLQIFGGKKETLVEAAKFVDQNTTADIIDINMGC PVPKITKCDAGAKWLLDPDKIYEMVSAVVDAVNKPVTVKMRMGWDEDHIFAVKNAQAV ERAGGKAVALHGRTRVQMYEGTANWDIIKEVKQSVSIPVIGNGDVKTPQDAKRMLDET GVDGVMIGRAALGNPWMIYRTVQYLETGKLKEEPQVREKMAVCKLHLDRLIDLKGENV AVREMRKHAAWYLKGVKGNANVRNEINHCETREEFVQLLDAFTVEVEAKELQNAKVG* " /label="dusB CDS" gene 87225..88226 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /label="dusB gene" S_feature complement(87641..89157) /Source="Nicolas_S_feature" /locus_tag="new_88050_89566_c" /HighExp="LoTm, C30, S6, S8, S5, S7, S3, S4, C90, G135" /AntisenseName="dusB" /AntisenseCor="-0.60218706634778196" /AntisenseRegPval="-27.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S41" S_feature 88227..88317 /Source="Nicolas_S_feature" /locus_tag="new_88636_88726" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, Diami, C30, LBGexp, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="SigA, SigI, SigA, SigEF, SigA, SigA, SigA" /TUlongPSig="0.621, 0.787, 1, 0.995, 1, 0.999, 1" /label="S42" CDS 88318..89817 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /EC_number="6.1.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14623972, 20649968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14623972, 20649968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lysyl-tRNA synthetase" /protein_id="NP_387963.1" /db_xref="EnsemblGenomes-Gn:BSU00820" /db_xref="EnsemblGenomes-Tr:CAB11858" /db_xref="GOA:P37477" /db_xref="InterPro:IPR002313" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018149" /db_xref="InterPro:IPR034762" /db_xref="SubtiList:BG10144" /db_xref="UniProtKB/Swiss-Prot:P37477" /translation="MSQEEHNHEELNDQLQVRRDKMNQLRDNGIDPFGARFERTHQSQ EVISAYQDLTKEELEEKAIEVTIAGRMMTKRGKGKAGFAHLQDLEGQIQIYVRKDSVG DDQYEIFKSSDLGDLIGVTGKVFKTNVGELSVKATSFELLTKALRPLPDKYHGLKDVE QRYRQRYLDLIVNPDSKHTFITRSKIIQAMRRYLDDHGYLEVETPTMHSIPGGASARP FITHHNALDIPLYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGVSTRHNPEFTMIEL YEAYADYKDIMSLTENLVAHIAQEVLGTTTIQYGEEQIDLKPEWKRIHMVDAVKEATG VDFWEEVTVEQAREYAKEHEVEIKDSMTVGHIINEFFEQKIEETLIQPTFIYGHPVEI SPLAKKNPEDPRFTDRFELFIVGREHANAFTELNDPIDQRERFEAQLKEREAGNDEAH LMDEDFVEALEYGMPPTGGLGIGIDRLVMLLTNAPSIRDVLLFPQMRQR*" /label="lysS CDS" gene 88318..89817 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /label="lysS gene" promotor_-10 complement(89141..89159) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(89157) /Source="Nicolas_upshifts" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(89175..89180) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 89798 /Source="Nicolas_upshifts" /id="D36" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="4.49559" /MaxDrop="4.89484" /score="4.33485487" /energy="-18.1" /TU="U76" /idTUdmin="U74" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 89893..89900 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 89909..90126 /Source="Nicolas_S_feature" /locus_tag="new_90318_90535" /HighExp="LBGstat, H2O2, Oxctl, Diami, dia15, Paraq, MG 25, Heat, MG 15, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 0.998, 1, 1, 0.999, 1" /label="S43" upshifts 89909 /Source="Nicolas_upshifts" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 89914..89933 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(89959) /Source="Nicolas_upshifts" /id="D37" /incds=0 /nref=3 /ntot=51 /MaxReadThrough="3.16217" /MaxDrop="5.0092" /score="18.6635354" /energy="-16.9" /TU="NA" /idTUdmin="U77" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" rRNA 90127..91680 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-16S rRNA" gene 90127..91680 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /label="rrnJ-16S gene" rRNA 91845..94772 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-23S rRNA" gene 91845..94772 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /label="rrnJ-23S gene" rRNA 94828..94945 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-5S rRNA" gene 94828..94945 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /label="rrnJ-5S gene" tRNA 94966..95041 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Val tRNA" gene 94966..95041 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /label="trnJ-Val gene" tRNA 95046..95121 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Thr tRNA" gene 95046..95121 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /label="trnJ-Thr gene" tRNA 95158..95233 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Lys tRNA" gene 95158..95233 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /label="trnJ-Lys gene" tRNA 95240..95322 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Leu1 tRNA" gene 95240..95322 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /label="trnJ-Leu1 gene" tRNA 95363..95437 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Gly tRNA" gene 95363..95437 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /label="trnJ-Gly gene" tRNA 95452..95537 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Leu2 tRNA" gene 95452..95537 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /label="trnJ-Leu2 gene" tRNA 95547..95623 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA(ACG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Arg tRNA" gene 95547..95623 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /label="trnJ-Arg gene" tRNA 95651..95727 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Pro(UGG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Pro tRNA" gene 95651..95727 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /label="trnJ-Pro gene" tRNA 95737..95812 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Ala tRNA" gene 95737..95812 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /label="trnJ-Ala gene" rRNA 95983..97536 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-16S rRNA" gene 95983..97536 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /label="rrnW-16S gene" rRNA 97701..100628 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-23S rRNA" gene 97701..100628 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /label="rrnW-23S gene" rRNA 100684..100802 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-5S rRNA" gene 100684..100802 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /label="rrnW-5S gene" S_feature 100803..100880 /Source="Nicolas_S_feature" /locus_tag="new_101212_101289" /HighExp="G135, G180, G150, Cold, Paraq, Oxctl, H2O2, C30, BMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S44" promotor_-35 100850..100853 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 100869..100888 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 100882 /Source="Nicolas_upshifts" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-35 100916..100922 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-35" promotor_-10 100936..100955 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-10" upshifts 100947 /Source="Nicolas_upshifts" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="upshifts" promotor_-35 100962..100969 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 100983..101002 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 100995 /Source="Nicolas_upshifts" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 101040..101504 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of class III stress genes" /protein_id="NP_387964.1" /db_xref="EnsemblGenomes-Gn:BSU00830" /db_xref="EnsemblGenomes-Tr:CAB11859" /db_xref="GOA:P37568" /db_xref="InterPro:IPR008463" /db_xref="SubtiList:BG10145" /db_xref="UniProtKB/Swiss-Prot:P37568" /translation="MGHNISDIIEQYLKRVLDQNGKEILEIKRSEIADKFQCVPSQIN YVINTRFTSERGYIVESKRGGGGYIRIIKIKMNNEVVLINNIISQINTHLSQAASDDI ILRLLEDKVISEREAKMMVSVMDRSVLHIDLPERDELRARMMKAMLTSLKLK*" /label="ctsR CDS" gene 101040..101504 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /label="ctsR gene" misc_feature complement(101151..101155) /Source="Nicolas_upshift_promotors" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(101157) /Source="Nicolas_upshifts" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 101518..102075 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 19189946, 24947607" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 19189946, 24947607; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of protein kinase McsB" /protein_id="NP_387965.1" /db_xref="EnsemblGenomes-Gn:BSU00840" /db_xref="EnsemblGenomes-Tr:CAB11860" /db_xref="GOA:P37569" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR025542" /db_xref="InterPro:IPR029037" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10146" /db_xref="UniProtKB/Swiss-Prot:P37569" /translation="MICQECHERPATFHFTKVVNGEKIEVHICEQCAKENSDSYGISA NQGFSIHNLLSGLLNMDSSFQNAGTQMFSHSEQISACPKCGMTFQQFRKIGRFGCSEC YKTFHSNITPILRKVHSGNTVHAGKIPKRIGGNLHVRRQIDMLKKELESLIHQEEFEN AAHVRDQIRLLEQSLKSTDSEEEQE*" /label="mcsA CDS" gene 101518..102075 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /label="mcsA gene" CDS 102075..103166 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /EC_number="2.7.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 17380125, 19189946, 21622759, 25610436, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 17380125, 19189946, 21622759, 25610436, 27749819; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein arginine kinase" /protein_id="NP_387966.1" /db_xref="EnsemblGenomes-Gn:BSU00850" /db_xref="EnsemblGenomes-Tr:CAB11861" /db_xref="GOA:P37570" /db_xref="InterPro:IPR000749" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR022414" /db_xref="InterPro:IPR022415" /db_xref="InterPro:IPR023660" /db_xref="SubtiList:BG10147" /db_xref="UniProtKB/Swiss-Prot:P37570" /translation="MSLKHFIQDALSSWMKQKGPESDIVLSSRIRLARNFEHIRFPTR YSNEEASSIIQQFEDQFSEQEIPGIGKFVLIRMNDAQPLEKRVLVEKHLISPNLTESP FGGCLLSENEEVSVMLNEEDHIRIQCLFPGFQLLEAMKAANQVDDWIEEKVDYAFNEQ RGYLTSCPTNVGTGLRASVMMHLPALVLTRQINRIIPAINQLGLVVRGIYGEGSEAVG NIFQISNQITLGKSEQDIVEDLNSVAAQLIEQERSAREAIYQTSKIELEDRVYRSYGV LSNCRMIESKETAKCLSDVRLGIDLGIIKGLSSNILNELMILTQPGFLQQYSGGALRP NERDIRRAALIRERLHLEMNGKRQEDESI*" /label="mcsB CDS" gene 102075..103166 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /label="mcsB gene" CDS 103163..105595 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354604, 15529410, 16525504, 26735940, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354604, 15529410, 16525504, 26735940, 27749819; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III stress response-related ATPase, AAA+ superfamily" /protein_id="NP_387967.1" /db_xref="EnsemblGenomes-Gn:BSU00860" /db_xref="EnsemblGenomes-Tr:CAB11862" /db_xref="GOA:P37571" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004176" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="InterPro:IPR036628" /db_xref="PDB:2K77" /db_xref="PDB:2Y1Q" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="PDB:5HBN" /db_xref="SubtiList:BG10148" /db_xref="UniProtKB/Swiss-Prot:P37571" /translation="MMFGRFTERAQKVLALAQEEALRLGHNNIGTEHILLGLVREGEG IAAKALQALGLGSEKIQKEVESLIGRGQEMSQTIHYTPRAKKVIELSMDEARKLGHSY VGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNETGSSAAGTNSNANT PTLDSLARDLTAIAKEDSLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIA EGLAQQIINNEVPEILRDKRVMTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIIL FIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDEYRKYIEKDAALERRF QPIQVDQPSVDESIQILQGLRDRYEAHHRVSITDDAIEAAVKLSDRYISDRFLPDKAI DLIDEAGSKVRLRSFTTPPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDTEQRLR EQVEDTKKSWKEKQGQENSEVTVDDIAMVVSSWTGVPVSKIAQTETDKLLNMENILHS RVIGQDEAVVAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAESIFGDE ESMIRIDMSEYMEKHSTSRLVGSPPGYVGYDEGGQLTEKVRRKPYSVVLLDEIEKAHP DVFNILLQVLEDGRLTDSKGRTVDFRNTILIMTSNVGASELKRNKYVGFNVQDETQNH KDMKDKVMGELKRAFRPEFINRIDEIIVFHSLEKKHLTEIVSLMSDQLTKRLKEQDLS IELTDAAKAKVAEEGVDLEYGARPLRRAIQKHVEDRLSEELLRGNIHKGQHIVLDVED GEFVVKTTAKTN*" /label="clpC CDS" gene 103163..105595 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /label="clpC gene" downshifts 105590 /Source="Nicolas_upshifts" /id="D38" /incds=0 /nref=57 /ntot=245 /MaxReadThrough="6.69446" /MaxDrop="4.4703" /score="-8.32149463" /energy="-11.7" /TU="U80,U81" /idTUdmin="U79" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS 105687..107063 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /EC_number="2.1.1.63" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931349, 11810266, 15317759, 25616256; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair protein; 6-O-methylguanine-DNA methyltransferase" /protein_id="NP_387968.1" /db_xref="EnsemblGenomes-Gn:BSU00870" /db_xref="EnsemblGenomes-Tr:CAB11863" /db_xref="GOA:P37572" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004504" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10149" /db_xref="UniProtKB/Swiss-Prot:P37572" /translation="MAKTKSKFICQSCGYESPKWMGKCPGCGAWNTMVEEMIKKAPAN RRAAFSHSVQTVQKPSPITSIETSEEPRVKTQLGEFNRVLGGGVVKGSLVLIGGDPGI GKSTLLLQVSAQLSGSSNSVLYISGEESVKQTKLRADRLGINNPSLHVLSETDMEYIS SAIQEMNPSFVVVDSIQTVYQSDITSAPGSVSQVRECTAELMKIAKTKGIPIFIVGHV TKEGSIAGPRLLEHMVDTVLYFEGERHHTFRILRAVKNRFGSTNEMGIFEMREEGLTE VLNPSEIFLEERSAGSAGSSITASMEGTRPILVEIQALISPTSFGNPRRMATGIDHNR VSLLMAVLEKRVGLLLQNQDAYLKVAGGVKLDEPAIDLAIVISIASSFRDTPPNPADC FIGEVGLTGEVRRVSRIEQRVKEAAKLGFKRMIIPAANLDGWTKPKGIEVIGVANVAE ALRTSLGG*" /label="radA CDS" gene 105687..107063 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /label="radA gene" promotor_-35 106142..106151 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 106164..106179 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 106167 /Source="Nicolas_upshifts" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 107067..108149 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase; DNA integrity scanning protein; cell cycle checkpoint DNA scanning protein" /protein_id="NP_387969.1" /db_xref="EnsemblGenomes-Gn:BSU00880" /db_xref="EnsemblGenomes-Tr:CAB11864" /db_xref="GOA:P37573" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR018906" /db_xref="InterPro:IPR023763" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG10150" /db_xref="UniProtKB/Swiss-Prot:P37573" /translation="MEKEKKGAKHELDLSSILQFVAPGTPLRAGMENVLRANTGGLIV VGYNDKVKEVVDGGFHINTAFSPAHLYELAKMDGAIILSDSGQKILYANTQLMPDATI SSSETGMRHRTAERVAKQTGCLVIAISERRNVITLYQENMKYTLKDIGFILTKANQAI QTLEKYKTILDKTINALNALEFEELVTFSDVLSVMHRYEMVLRIKNEINMYIKELGTE GHLIKLQVIELITDMEEEAALFIKDYVKEKIKDPFVLLKELQDMSSYDLLDDSIVYKL LGYPASTNLDDYVLPRGYRLLNKIPRLPMPIVENVVEAFGVLPRIIEASAEELDEVEG IGEVRAQKIKKGLKRLQEKHYLDRQL*" /label="disA CDS" gene 107067..108149 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /label="disA gene" S_feature 108150..108264 /Source="Nicolas_S_feature" /locus_tag="new_108559_108673" /HighExp="Etha, Salt, Heat, dia15, Diami, M9-stat, B60, T-0.40H, T-1.10H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.947" /label="S45" CDS 108265..109365 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26999498; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein possibly involved in RNA binding" /protein_id="NP_387970.1" /db_xref="EnsemblGenomes-Gn:BSU00890" /db_xref="EnsemblGenomes-Tr:CAB11865" /db_xref="GOA:Q06754" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG10151" /db_xref="UniProtKB/Swiss-Prot:Q06754" /translation="MLKRIVQAFFIIFGGVVGIFLIPELFVLLNIQDIPLITNAYTSA AIGAIIFFLISIWGTEYVVNWVKWIEDSLLKAPVPDLLFGSLGLVFGLIIAYLIVNVI PLDNIPYRIFSTIIPVFLAFFLGYLGFQVGFKKKDELISLFSISARMQKKKGTADEEH EVQDKKLKILDTSVIIDGRIADICQTGFLEGVIVIPQFVLEELQHIADSSDVLKRNRG RRGLDILNRIQKELDIEVEIYEGDFEDIQEVDSKLVKLAKLTSGVVVTNDFNLNKVCE LQKVAVLNINDLANAVKPVVLPGEEMNVQVIKDGKEHNQGVAYLDDGTMIVVEEGRNY IGKHIDVLVTSVLQTAAGRMIFAKPKLLEKAL*" /label="yacL CDS" gene 108265..109365 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /label="yacL gene" downshifts complement(109187) /Source="Nicolas_upshifts" /id="D39" /incds=1 /nref=1 /ntot=103 /MaxReadThrough="0.39171" /MaxDrop="2.87304" /score="-9.71423487" /energy="-11.8" /TU="NA" /idTUdmin="U82" /TUdmin="-8228" /isTUend="FALSE" /label="downshifts" CDS 109380..110078 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /EC_number="2.7.7.60" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, nonmevalonate isoprenoid pathway" /protein_id="NP_387971.1" /db_xref="EnsemblGenomes-Gn:BSU00900" /db_xref="EnsemblGenomes-Tr:CAB11866" /db_xref="GOA:Q06755" /db_xref="InterPro:IPR001228" /db_xref="InterPro:IPR018294" /db_xref="InterPro:IPR029044" /db_xref="InterPro:IPR034683" /db_xref="PDB:5DDT" /db_xref="PDB:5DDV" /db_xref="PDB:5HS2" /db_xref="SubtiList:BG10152" /db_xref="UniProtKB/Swiss-Prot:Q06755" /translation="MSYDVVIPAAGQGKRMKAGRNKLFIELKGDPVIIHTLRVFDSHR QCDKIILVINEQEREHFQQLLSDYPFQTSIELVAGGDERQHSVYKGLKAVKQEKIVLV HDGARPFIKHEQIDELIAEAEQTGAAILAVPVKDTIKRVQDLQVSETIERSSLWAVQT PQAFRLSLLMKAHAEAERKGFLGTDDASLVEQMEGGSVRVVEGSYTNIKLTTPDDLTS AEAIMESESGNKHV*" /label="ispD CDS" gene 109380..110078 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /label="ispD gene" CDS 110071..110547 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /EC_number="4.6.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9622350, 11997478, 12270818, 12682299, 17458547, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 11997478, 12270818, 12682299, 17458547, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase" /protein_id="NP_387972.1" /db_xref="EnsemblGenomes-Gn:BSU00910" /db_xref="EnsemblGenomes-Tr:CAB11867" /db_xref="GOA:Q06756" /db_xref="InterPro:IPR003526" /db_xref="InterPro:IPR020555" /db_xref="InterPro:IPR036571" /db_xref="PDB:5IWX" /db_xref="PDB:5IWY" /db_xref="SubtiList:BG10153" /db_xref="UniProtKB/Swiss-Prot:Q06756" /translation="MFRIGQGFDVHQLVEGRPLIIGGIEIPYEKGLLGHSDADVLLHT VADACLGAVGEGDIGKHFPDTDPEFKDADSFKLLQHVWGIVKQKGYVLGNIDCTIIAQ KPKMLPYIEDMRKRIAEGLEADVSQVNVKATTTEKLGFTGRAEGIAAQATVLIQKG*" /label="ispF CDS" gene 110071..110547 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /label="ispF gene" promotor_-35 110551..110558 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 110572..110591 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 110585 /Source="Nicolas_upshifts" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 110638..112089 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /EC_number="6.1.1.24" /EC_number="6.1.1.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA synthetase" /protein_id="NP_387973.1" /db_xref="EnsemblGenomes-Gn:BSU00920" /db_xref="EnsemblGenomes-Tr:CAB11868" /db_xref="GOA:P22250" /db_xref="InterPro:IPR000924" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR004527" /db_xref="InterPro:IPR008925" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020058" /db_xref="InterPro:IPR020061" /db_xref="InterPro:IPR020751" /db_xref="InterPro:IPR020752" /db_xref="InterPro:IPR033910" /db_xref="SubtiList:BG10154" /db_xref="UniProtKB/Swiss-Prot:P22250" /translation="MGNEVRVRYAPSPTGHLHIGNARTALFNYLFARNQGGKFIIRVE DTDKKRNIEGGEQSQLNYLKWLGIDWDESVDVGGEYGPYRQSERNDIYKVYYEELLEK GLAYKCYCTEEELEKEREEQIARGEMPRYSGKHRDLTQEEQEKFIAEGRKPSIRFRVP EGKVIAFNDIVKGEISFESDGIGDFVIVKKDGTPTYNFAVAIDDYLMKMTHVLRGEDH ISNTPKQIMIYQAFGWDIPQFGHMTLIVNESRKKLSKRDESIIQFIEQYKELGYLPEA LFNFIGLLGWSPVGEEELFTKEQFIEIFDVNRLSKSPALFDMHKLKWVNNQYVKKLDL DQVVELTLPHLQKAGKVGTELSAEEQEWVRKLISLYHEQLSYGAEIVELTDLFFTDEI EYNQEAKAVLEEEQVPEVLSTFAAKLEELEEFTPDNIKASIKAVQKETGHKGKKLFMP IRVAVTGQTHGPELPQSIELIGKETAIQRLKNI*" /label="gltX CDS" gene 110638..112089 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /label="gltX gene" promotor_-35 111567..111576 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-35" promotor_-10 111590..111609 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-10" upshifts 111590 /Source="Nicolas_upshifts" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="upshifts" S_feature 112090..112390 /Source="Nicolas_S_feature" /locus_tag="new_112499_112799" /HighExp="S6, S8, S7, Diami, C90, LBGexp, G135, H2O2, dia5, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.17844199999999999" /TUshortSig="SigK, SigA, SigWXY" /TUshortPSig="1, 0.999, 1" /TUlongSig="SigA, SigB, SigA" /TUlongPSig="1, 1, 0.947" /label="S46" CDS 112391..113044 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /EC_number="2.3.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7510287, 10737181, 10939241, 17056751, 18974048, 25731080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7510287, 10737181, 10939241, 17056751, 18974048, 25731080; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine O-acetyltransferase" /protein_id="NP_387974.1" /db_xref="EnsemblGenomes-Gn:BSU00930" /db_xref="EnsemblGenomes-Tr:CAB11869" /db_xref="GOA:Q06750" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005881" /db_xref="InterPro:IPR010493" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="SubtiList:BG10155" /db_xref="UniProtKB/Swiss-Prot:Q06750" /translation="MFFRMLKEDIDTVFDQDPAARSYFEVILTYSGLHAIWAHRIAHA LYKRKFYFLARLISQVSRFFTGIEIHPGATIGRRFFIDHGMGVVIGETCEIGNNVTVF QGVTLGGTGKEKGKRHPTIKDDALIATGAKVLGSITVGEGSKIGAGSVVLHDVPDFST VVGIPGRVVVQNGKKVRRDLNHQDLPDPVADRFKSLEQQILELKAELEDRKERINQK* " /label="cysE CDS" gene 112391..113044 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /label="cysE gene" CDS 113041..114441 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /EC_number="6.1.1.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10024179, 10546897, 10931887, 12682299, 29079736" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024179, 10546897, 10931887, 12682299, 29079736; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual cysteinyl-tRNA synthetase; cysteine persulfide synthase" /protein_id="NP_387975.1" /db_xref="EnsemblGenomes-Gn:BSU00940" /db_xref="EnsemblGenomes-Tr:CAB11870" /db_xref="GOA:Q06752" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015273" /db_xref="InterPro:IPR015803" /db_xref="InterPro:IPR024909" /db_xref="InterPro:IPR032678" /db_xref="SubtiList:BG10156" /db_xref="UniProtKB/Swiss-Prot:Q06752" /translation="MTITLYNTLTRQKETFVPLEEGKVKMYVCGPTVYNYIHIGNARP AIVYDTVRNYLEYKGYDVQYVSNFTDVDDKLIKAANELGEDVPTISERFIKAYFEDVG ALGCRKADLHPRVMENMDAIIEFVDQLVKKGYAYESEGDVYFKTRAFEGYGKLSQQSI DELRSGARIRVGEKKEDALDFALWKAAKEGEISWDSPWGKGRPGWHIECSAMVKKYLG DQIDIHAGGQDLTFPHHENEIAQSEALTGKTFAKYWLHNGYINIDNEKMSKSLGNFVL VHDIIKQHDPQLLRFFMLSVHYRHPINYSEELLENTKSAFSRLKTAYSNLQHRLNSST NLTEDDDQWLEKVEEHRKAFEEEMDDDFNTANAISVLFDLAKHANYYLQKDHTADHVI TAFIEMFDRIVSVLGFSLGEQELLDQEIEDLIEKRNEARRNRDFALSDQIRDQLKSMN IILEDTAQGTRWKRGE*" /label="cysS CDS" gene 113041..114441 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /label="cysS gene" CDS 114445..114876 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 25634891, 27924926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 25634891, 27924926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease for 23S RNA maturation, mini-RNase III" /protein_id="NP_387976.1" /db_xref="EnsemblGenomes-Gn:BSU00950" /db_xref="EnsemblGenomes-Tr:CAB11871" /db_xref="GOA:O31418" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR008226" /db_xref="InterPro:IPR036389" /db_xref="PDB:4OUN" /db_xref="SubtiList:BG12702" /db_xref="UniProtKB/Swiss-Prot:O31418" /translation="MLEFDTIKDSKQLNGLALAYIGDAIFEVYVRHHLLKQGFTKPND LHKKSSRIVSAKSQAEILFFLQNQSFFTEEEEAVLKRGRNAKSGTTPKNTDVQTYRYS TAFEALLGYLFLEKKEERLSQLVAEAIQFGTSGRKTNESAT*" /label="mrnC CDS" gene 114445..114876 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /label="mrnC gene" CDS 114860..115609 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /EC_number="2.1.1.185" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11698387, 12377117, 16014871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (Gm2251)-methyltransferase" /protein_id="NP_387977.1" /db_xref="EnsemblGenomes-Gn:BSU00960" /db_xref="EnsemblGenomes-Tr:CAB11872" /db_xref="GOA:Q06753" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR004441" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG10157" /db_xref="UniProtKB/Swiss-Prot:Q06753" /translation="MSQQHDYVIGKNAVIETLKSDRKLYKLWMAENTVKGQAQQVIEL AKKQGITIQYVPRKKLDQMVTGQHQGVVAQVAAYEYAELDDLYKAAEEKNEQPFFLIL DELEDPHNLGSIMRTADAVGAHGIVIPKRRAVGLTTTVAKASTGAIEHIPVARVTNLA RTLEEMKERGIWVVGTDASAREDFRNMDGNMPLALVIGSEGKGMGRLVKEKCDFLIKL PMAGKVTSLNASVAAGLLMYEVYRKRNPVGE*" /label="rlmB CDS" gene 114860..115609 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /label="rlmB gene" CDS 115616..116128 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17114934, 23355615, 28363943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17114934, 23355615, 28363943; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-dependent mRNA endonuclease" /protein_id="NP_387978.1" /db_xref="EnsemblGenomes-Gn:BSU00970" /db_xref="EnsemblGenomes-Tr:CAB11873" /db_xref="InterPro:IPR010298" /db_xref="PDB:5MQ8" /db_xref="PDB:5MQ9" /db_xref="SubtiList:BG10158" /db_xref="UniProtKB/Swiss-Prot:P37574" /translation="MDILLVDGYNMIGAWPQLKDLKANSFEEARDVLIQKMAEYQSYT GNRVIVVFDAHLVKGLEKKQTNHRVEVIFTKENETADERIEKLAQALNNIATQIHVAT SDYTEQWAIFGQGALRKSARELLREVETIERRIERRVRKITSEKPAGKIALSEEVLKT FEKWRRGDLD*" /label="raeA CDS" gene 115616..116128 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /label="raeA gene" promotor_-35 116127..116134 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 116149..116168 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 116151 /Source="Nicolas_upshifts" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 116191..116847 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169614, 16339734, 25288929, 26712348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169614, 16339734, 25288929, 26712348; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-30 factor (sigma(H))" /protein_id="NP_387979.1" /db_xref="EnsemblGenomes-Gn:BSU00980" /db_xref="EnsemblGenomes-Tr:CAB11874" /db_xref="GOA:P17869" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014218" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR016371" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10159" /db_xref="UniProtKB/Swiss-Prot:P17869" /translation="MNLQNNKGKFNKEQFCQLEDEQVIEKVHVGDSDALDYLITKYRN FVRAKARSYFLIGADREDIVQEGMIGLYKSIRDFKEDKLTSFKAFAELCITRQIITAI KTATRQKHIPLNSYASLDKPIFDEESDRTLLDVISGAKTLNPEEMIINQEEFDDIEMK MGELLSDLERKVLVLYLDGRSYQEISDELNRHVKSIDNALQRVKRKLEKYLEIREISL *" /label="sigH CDS" gene 116191..116847 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /label="sigH gene" downshifts complement(116645) /Source="Nicolas_upshifts" /id="D40" /incds=1 /nref=1 /ntot=107 /MaxReadThrough="2.38622" /MaxDrop="2.50464" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=836 /isTUend="FALSE" /label="downshifts" S_feature 116848..116939 /Source="Nicolas_S_feature" /locus_tag="new_117257_117348" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, S1, S2, T5.0H, HiOs, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S47" CDS 116940..117089 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586115, 19648245, 23002217, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586115, 19648245, 23002217, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_387980.1" /db_xref="EnsemblGenomes-Gn:BSU00990" /db_xref="EnsemblGenomes-Tr:CAB11875" /db_xref="GOA:Q06798" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="SubtiList:BG10160" /db_xref="UniProtKB/Swiss-Prot:Q06798" /translation="MRKKITLACKTCGNRNYTTMKSSASAAERLEVKKYCSTCNSHTA HLETK*" /label="rpmGB CDS" gene 116940..117089 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /label="rpmGB gene" CDS 117123..117302 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11976315, 12682299, 16242710, 22304380, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11976315, 12682299, 16242710, 22304380, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_387981.1" /db_xref="EnsemblGenomes-Gn:BSU01000" /db_xref="EnsemblGenomes-Tr:CAB11876" /db_xref="GOA:Q06799" /db_xref="InterPro:IPR001901" /db_xref="InterPro:IPR005807" /db_xref="InterPro:IPR022943" /db_xref="SubtiList:BG10161" /db_xref="UniProtKB/Swiss-Prot:Q06799" /translation="MRIMKFFKDVGKEMKKVSWPKGKELTRYTITVISTVIFFVIFFA LLDTGISQLIRLIVE*" /label="secE CDS" gene 117123..117302 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /label="secE gene" S_feature 117303..117480 /Source="Nicolas_S_feature" /locus_tag="new_117712_117889" /HighExp="Cold, G180, G150, H2O2, LoTm, Oxctl, G135, Paraq, LBGexp, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S48" downshifts complement(117474) /Source="Nicolas_upshifts" /id="D41" /incds=0 /nref=37 /ntot=175 /MaxReadThrough="1.57397" /MaxDrop="4.03552" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 117481..118014 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11101662, 16014871, 16707701, 18852477, 26742846, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101662, 16014871, 16707701, 18852477, 26742846, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase elongation pause factor" /protein_id="NP_387982.1" /db_xref="EnsemblGenomes-Gn:BSU01010" /db_xref="EnsemblGenomes-Tr:CAB11877" /db_xref="GOA:Q06795" /db_xref="InterPro:IPR001062" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR006645" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015869" /db_xref="InterPro:IPR036735" /db_xref="SubtiList:BG10162" /db_xref="UniProtKB/Swiss-Prot:Q06795" /translation="MEKNWYVVHTYSGYENKVKANLEKRVESMGMQDKIFRVVVPEEE ETDIKNGKKKVVKKKVFPGYVLVEIVMTDDSWYVVRNTPGVTGFVGSAGSGSKPTPLL PGEAETILKRMGMDERKTDIDFELKETVKVIDGPFANFTGSIEEIDYDKSKVKVFVNM FGRETPVELEFTQIDKL*" /label="nusG CDS" gene 117481..118014 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /label="nusG gene" upshifts complement(117569) /Source="Nicolas_upshifts" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(117572..117576) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(117591..117596) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 118025..118032 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 118043..118181 /Source="Nicolas_S_feature" /locus_tag="new_118452_118590" /HighExp="T-1.40H, ferm, T-3.40H, T-5.40H, BI, B36, LoTm, SMM, T-2.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S49" upshifts 118043 /Source="Nicolas_upshifts" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 118046..118065 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 118182..118607 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11244072, 19653700, 20441189" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244072, 19653700, 20441189; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 (BL11)" /protein_id="NP_387983.2" /db_xref="EnsemblGenomes-Gn:BSU01020" /db_xref="EnsemblGenomes-Tr:CAB11878" /db_xref="GOA:Q06796" /db_xref="InterPro:IPR000911" /db_xref="InterPro:IPR006519" /db_xref="InterPro:IPR020783" /db_xref="InterPro:IPR020784" /db_xref="InterPro:IPR020785" /db_xref="InterPro:IPR036769" /db_xref="InterPro:IPR036796" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG10163" /db_xref="UniProtKB/Swiss-Prot:Q06796" /translation="MAKKVVKVVKLQIPAGKANPAPPVGPALGQAGVNIMGFCKEFNA RTADQAGLIIPVEISVYEDRSFTFITKTPPAAVLLKKAAGIESGSGEPNRNKVATVKR DKVREIAETKMPDLNAADVEAAMRMVEGTARSMGIVIED*" /label="rplK CDS" gene 118182..118607 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /label="rplK gene" S_feature 118608..118701 /Source="Nicolas_S_feature" /locus_tag="new_119017_119110" /HighExp="HPh, LPh, Lbexp, G180, LBGexp, G150, Heat, Cold, Fru, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S50" CDS 118702..119400 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16352840, 17981968, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L1 (BL1)" /protein_id="NP_387984.2" /db_xref="EnsemblGenomes-Gn:BSU01030" /db_xref="EnsemblGenomes-Tr:CAB11879" /db_xref="GOA:Q06797" /db_xref="InterPro:IPR002143" /db_xref="InterPro:IPR005878" /db_xref="InterPro:IPR016095" /db_xref="InterPro:IPR023673" /db_xref="InterPro:IPR023674" /db_xref="InterPro:IPR028364" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="SubtiList:BG10164" /db_xref="UniProtKB/Swiss-Prot:Q06797" /translation="MAKKGKKYVEAAKLVDRSKAYDVSEAVALVKKTNTAKFDATVEV AFRLGVDPRKNDQQIRGAVVLPNGTGKTQRVLVFAKGEKAKEAEAAGADFVGDTDYIN KIQQGWFDFDVIVATPDMMGEVGKIGRVLGPKGLMPNPKTGTVTFEVEKAIGEIKAGK VEYRVDKAGNIHVPIGKVSFEDEKLVENFTTMYDTILKAKPAAAKGVYVKNVAVTSTM GPGVKVDSSTFNVK*" /label="rplA CDS" gene 118702..119400 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /label="rplA gene" downshifts complement(119374) /Source="Nicolas_upshifts" /id="D42" /incds=0 /nref=3 /ntot=95 /MaxReadThrough="3.54108" /MaxDrop="3.36566" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U89" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA 119446..119586 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /product="L10_leader" /experiment="publication(s) with functional evidences, PMID:26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26101249; Product type n: RNA" /label="ldlJ RNA" gene 119446..119586 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /label="ldlJ gene" upshifts complement(119462) /Source="Nicolas_upshifts" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(119465..119469) /Source="Nicolas_upshift_promotors" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 119518 /Source="Nicolas_upshifts" /id="D43" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="9.14839" /MaxDrop="2.9211" /score="20.0562348" /energy="-13.2" /TU="U88" /idTUdmin="U84" /TUdmin=1497 /isTUend="FALSE" /label="downshifts" CDS 119652..120152 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9810686, 11341315, 12682299, 18247578, 26101249, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9810686, 11341315, 12682299, 18247578, 26101249, 22720735; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L10 (BL5)" /protein_id="NP_387985.2" /db_xref="EnsemblGenomes-Gn:BSU01040" /db_xref="EnsemblGenomes-Tr:CAB11880" /db_xref="GOA:P42923" /db_xref="InterPro:IPR001790" /db_xref="InterPro:IPR002363" /db_xref="InterPro:IPR022973" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11220" /db_xref="UniProtKB/Swiss-Prot:P42923" /translation="MSSAIETKKVVVEEIASKLKESKSTIIVDYRGLNVSEVTELRKQ LREANVEFKVYKNTMTRRAVEQAELNGLNDFLTGPNAIAFSTEDVVAPAKVLNDFAKN HEALEIKAGVIEGKVSTVEEVKALAELPSREGLLSMLLSVLQAPVRNLALAAKAVAEQ KEEQGA*" /label="rplJ CDS" gene 119652..120152 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /label="rplJ gene" CDS 120198..120569 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 6771249, 8755892, 26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 6771249, 8755892, 26101249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L12 (BL9)" /protein_id="NP_387986.1" /db_xref="EnsemblGenomes-Gn:BSU01050" /db_xref="EnsemblGenomes-Tr:CAB11881" /db_xref="GOA:P02394" /db_xref="InterPro:IPR000206" /db_xref="InterPro:IPR008932" /db_xref="InterPro:IPR013823" /db_xref="InterPro:IPR014719" /db_xref="InterPro:IPR036235" /db_xref="SubtiList:BG10726" /db_xref="UniProtKB/Swiss-Prot:P02394" /translation="MALNIEEIIASVKEATVLELNDLVKAIEEEFGVTAAAPVAVAGG AAAGGAAEEQSEFDLILAGAGSQKIKVIKVVREITGLGLKEAKELVDNTPKPLKEGIA KEEAEELKAKLEEVGASVEVK*" /label="rplL CDS" gene 120198..120569 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /label="rplL gene" downshifts 120485 /Source="Nicolas_upshifts" /id="D44" /incds=1 /nref=5 /ntot=149 /MaxReadThrough="8.89506" /MaxDrop="4.0945" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2464 /isTUend="FALSE" /label="downshifts" downshifts 120558 /Source="Nicolas_upshifts" /id="D45" /incds=0 /nref=25 /ntot=157 /MaxReadThrough="7.44654" /MaxDrop="4.0033" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2537 /isTUend="FALSE" /label="downshifts" CDS 120659..121264 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /EC_number="2.1.1.174" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17010380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2G1835 methyltransferase" /protein_id="NP_387987.1" /db_xref="EnsemblGenomes-Gn:BSU01060" /db_xref="EnsemblGenomes-Tr:CAB11882" /db_xref="GOA:P37872" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10727" /db_xref="UniProtKB/Swiss-Prot:P37872" /translation="MSEHYYSEKPSVKSNKQTWSFRLRNKDFTFTSDSGVFSKKEVDF GSRLLIDSFEEPEVEGGILDVGCGYGPIGLSLASDFKDRTIHMIDVNERAVELSNENA EQNGITNVKIYQSDLFSNVDSAQTFASILTNPPIRAGKKVVHAIFEKSAEHLKASGEL WIVIQKKQGAPSAIEKLEELFDEVSVVQKKKGYYIIKAKKV*" /label="rlmG CDS" gene 120659..121264 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /label="rlmG gene" promotor_-35 121259..121263 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 121277..121509 /Source="Nicolas_S_feature" /locus_tag="new_121686_121918" /HighExp="G180, G150, H2O2, G135, Cold, T-5.40H, LoTm, T-3.40H, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S51" upshifts 121277 /Source="Nicolas_upshifts" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 121279..121298 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 121510..125091 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10049799, 10744988, 12455702, 12682299, 15060052, 28163698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10049799, 10744988, 12455702, 12682299, 15060052, 28163698; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta subunit)" /protein_id="NP_387988.2" /db_xref="EnsemblGenomes-Gn:BSU01070" /db_xref="EnsemblGenomes-Tr:CAB11883" /db_xref="GOA:P37870" /db_xref="InterPro:IPR007120" /db_xref="InterPro:IPR007121" /db_xref="InterPro:IPR007641" /db_xref="InterPro:IPR007642" /db_xref="InterPro:IPR007644" /db_xref="InterPro:IPR007645" /db_xref="InterPro:IPR010243" /db_xref="InterPro:IPR015712" /db_xref="InterPro:IPR019462" /db_xref="PDB:2LY7" /db_xref="SubtiList:BG10728" /db_xref="UniProtKB/Swiss-Prot:P37870" /translation="MTGQLVQYGRHRQRRSYARISEVLELPNLIEIQTSSYQWFLDEG LREMFQDISPIEDFTGNLSLEFIDYSLGEPKYPVEESKERDVTYSAPLRVKVRLINKE TGEVKDQDVFMGDFPIMTDTGTFIINGAERVIVSQLVRSPSVYFSGKVDKNGKKGFTA TVIPNRGAWLEYETDAKDVVYVRIDRTRKLPVTVLLRALGFGSDQEILDLIGENEYLR NTLDKDNTENSDKALLEIYERLRPGEPPTVENAKSLLDSRFFDPKRYDLANVGRYKIN KKLHIKNRLFNQRLAETLVDPETGEILAEKGQILDRRTLDKVLPYLENGIGFRKLYPN GGVVEDEVTLQSIKIFAPTDQEGEQVINVIGNAYIEEEIKNITPADIISSISYFFNLL HGVGDTDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMSIQDTNTITPQQLIN IRPVIASIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGPGGLTRERAGMEVRDVHY SHYGRMCPIETPEGPNIGLINSLSSYAKVNRFGFIETPYRRVDPETGKVTGRIDYLTA DEEDNYVVAQANARLDDEGAFIDDSIVARFRGENTVVSRNRVDYMDVSPKQVVSAATA CIPFLENDDSNRALMGANMQRQAVPLMQPEAPFVGTGMEYVSGKDSGAAVICKHPGIV ERVEAKNVWVRRYEEVDGQKVKGNLDKYSLLKFVRSNQGTCYNQRPIVSVGDEVVKGE ILADGPSMELGELALGRNVMVGFMTWDGYNYEDAIIMSERLVKDDVYTSIHIEEYESE ARDTKLGPEEITRDIPNVGEDALRNLDDRGIIRIGAEVKDGDLLVGKVTPKGVTELTA EERLLHAIFGEKAREVRDTSLRVPHGGGGIIHDVKVFNREDGDELPPGVNQLVRVYIV QKRKISEGDKMAGRHGNKGVISKILPEEDMPYLPDGTPIDIMLNPLGVPSRMNIGQVL ELHMGMAARYLGIHIASPVFDGAREEDVWETLEEAGMSRDAKTVLYDGRTGEPFDNRV SVGIMYMIKLAHMVDDKLHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGA AYTLQEILTVKSDDVVGRVKTYEAIVKGDNVPEPGVPESFKVLIKELQSLGMDVKILS GDEEEIEMRDLEDEEDAKQADGLALSGDEEPEETASADVERDVVTKE*" /label="rpoB CDS" gene 121510..125091 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /label="rpoB gene" promotor_-10 complement(123095..123114) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123098) /Source="Nicolas_upshifts" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(123128..123137) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(123966..123970) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123971) /Source="Nicolas_upshifts" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(123985..123991) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 125153..128752 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta' subunit)" /protein_id="NP_387989.2" /db_xref="EnsemblGenomes-Gn:BSU01080" /db_xref="EnsemblGenomes-Tr:CAB11884" /db_xref="GOA:P37871" /db_xref="InterPro:IPR000722" /db_xref="InterPro:IPR006592" /db_xref="InterPro:IPR007066" /db_xref="InterPro:IPR007080" /db_xref="InterPro:IPR007081" /db_xref="InterPro:IPR007083" /db_xref="InterPro:IPR012754" /db_xref="SubtiList:BG10729" /db_xref="UniProtKB/Swiss-Prot:P37871" /translation="MLDVNNFEYMNIGLASPDKIRSWSFGEVKKPETINYRTLKPEKD GLFCERIFGPTKDWECHCGKYKRVRYKGVVCDRCGVEVTRAKVRRERMGHIELAAPVS HIWYFKGIPSRMGLVLDMSPRALEEVIYFASYVVTDPANTPLEKKQLLSEKEYRAYLD KYGNKFQASMGAEAIHKLLQDIDLVKEVDMLKEELKTSQGQRRTRAIKRLEVLEAFRN SGNKPSWMILDVLPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGA PSIIVQNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGK RVDYSGRSVIVVGPHLKMYQCGLPKEMALELFKPFVMKELVEKGLAHNIKSAKRKIER VQPEVWDVLESVIKEHPVLLNRAPTLHRLGIQAFEPTLVEGRAIRLHPLVCTAYNADF DGDQMAVHVPLSAEAQAEARILMLAAQNILNPKDGKPVVTPSQDMVLGNYYLTLERAG AVGEGMVFKNTDEALLAYQNGYVHLHTRVAVAANSLKNVTFTEEQRSKLLITTVGKLV FNEILPESFPYMNEPTKSNIEEKTPDRFFLEKGADVKAVIAQQPINAPFKKGILGKII AEIFKRFHITETSKMLDRMKNLGFKYSTKAGITVGVSDIVVLDDKQEILEEAQSKVDN VMKQFRRGLITEEERYERVISIWSAAKDVIQGKLMKSLDELNPIYMMSDSGARGNASN FTQLAGMRGLMANPAGRIIELPIKSSFREGLTVLEYFISTHGARKGLADTALKTADSG YLTRRLVDVAQDVIIRETDCGTDRGILAKPLKEGTETIERLEERLIGRFARKQVKHPE TGEVLVNENELIDEDKALEIVEAGIEEVWIRSAFTCNTPHGVCKRCYGRNLATGSDVE VGEAVGIIAAQSIGEPGTQLTMRTFHTGGVAGDDITQGLPRIQELFEARNPKGQATIT EIDGTVVEINEVRDKQQEIVVQGAVETRSYTAPYNSRLKVAEGDKITRGQVLTEGSID PKELLKVTDLTTVQEYLLHEVQKVYRMQGVEIGDKHVEVMVRQMLRKVRVIDAGDTDV LPGTLLDIHQFTEANKKVLLEGNRPATGRPVLLGITKASLETDSFLSAASFQETTRVL TDAAIKGKRDELLGLKENVIIGKLVPAGTGMMKYRKVKPVSNVQPTDDMVPVE*" /label="rpoC CDS" gene 125153..128752 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /label="rpoC gene" downshifts complement(128217) /Source="Nicolas_upshifts" /id="D46" /incds=1 /nref=1 /ntot=76 /MaxReadThrough="3.40002" /MaxDrop="2.38911" /score="-2.05539956" /energy="-7.5" /TU="U93" /idTUdmin="U93" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" upshifts complement(128371) /Source="Nicolas_upshifts" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(128389..128390) /Source="Nicolas_upshift_promotors" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(128701) /Source="Nicolas_upshifts" /id="D47" /incds=0 /nref=98 /ntot=210 /MaxReadThrough="1.61828" /MaxDrop="4.90549" /score="-2.05539956" /energy="-7.5" /TU="NA" /idTUdmin="U95" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 128753..128874 /Source="Nicolas_S_feature" /locus_tag="new_129162_129283" /HighExp="LoTm, HiOs, S3, SMMPr, Heat, S1, BC, Glu, S4, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S52" promotor_-35 128856..128863 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" upshifts 128876 /Source="Nicolas_upshifts" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 128877..128896 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" misc_feature complement(128894..128898) /Source="Nicolas_upshift_promotors" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(128897) /Source="Nicolas_upshifts" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 128931..129179 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein; alternative ribosomal protein L7A" /protein_id="NP_387990.1" /db_xref="EnsemblGenomes-Gn:BSU01090" /db_xref="EnsemblGenomes-Tr:CAB11885" /db_xref="GOA:P46350" /db_xref="InterPro:IPR000948" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR023460" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7E" /db_xref="PDB:4LCK" /db_xref="PDB:4TZP" /db_xref="PDB:4TZV" /db_xref="PDB:4TZW" /db_xref="PDB:4TZZ" /db_xref="SubtiList:BG11365" /db_xref="UniProtKB/Swiss-Prot:P46350" /translation="MSYDKVSQAKSIIIGTKQTVKALKRGSVKEVVVAKDADPILTSS VVSLAEDQGISVSMVESMKKLGKACGIEVGAAAVAIIL*" /label="rulS CDS" gene 128931..129179 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /label="rulS gene" S_feature 129180..129292 /Source="Nicolas_S_feature" /locus_tag="new_129589_129701" /HighExp="T-3.40H, M/G, T-1.40H, T-5.40H, Salt, Mal, T-0.40H, G/S, M9-exp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S53" CDS 129293..129709 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11489846, 12682299, 16484214, 18252828, 19383706, 20007320" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489846, 12682299, 16484214, 18252828, 19383706, 20007320; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S12 (BS12)" /protein_id="NP_387991.2" /db_xref="EnsemblGenomes-Gn:BSU01100" /db_xref="EnsemblGenomes-Tr:CAB11886" /db_xref="GOA:P21472" /db_xref="InterPro:IPR005679" /db_xref="InterPro:IPR006032" /db_xref="InterPro:IPR012340" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19009" /db_xref="UniProtKB/Swiss-Prot:P21472" /translation="MPTINQLIRKGRVSKVENSKSPALNKGYNSFKKEHTNVSSPQKR GVCTRVGTMTPKKPNSALRKYARVRLTNGIEVTAYIPGIGHNLQEHSVVLIRGGRVKD LPGVRYHIVRGALDTAGVENRAQGRSKYGTKKPKAK*" /label="rpsL CDS" gene 129293..129709 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /label="rpsL gene" CDS 129751..130221 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 19653700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 19653700; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S7 (BS7)" /protein_id="NP_387992.2" /db_xref="EnsemblGenomes-Gn:BSU01110" /db_xref="EnsemblGenomes-Tr:CAB11887" /db_xref="GOA:P21469" /db_xref="InterPro:IPR000235" /db_xref="InterPro:IPR005717" /db_xref="InterPro:IPR020606" /db_xref="InterPro:IPR023798" /db_xref="InterPro:IPR036823" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19006" /db_xref="UniProtKB/Swiss-Prot:P21469" /translation="MPRKGPVAKRDVLPDPIYNSKLVSRLINKMMIDGKKGKSQTILY KSFDIIKERTGNDAMEVFEQALKNIMPVLEVKARRVGGANYQVPVEVRPERRTTLGLR WLVNYARLRGEKTMEERLANEILDAANNTGAAVKKREDTHKMAEANKAFAHYRW*" /label="rpsG CDS" gene 129751..130221 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /label="rpsG gene" CDS 130275..132353 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:815236, 815243, 1556067, 4629789, 19366171, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 815236, 815243, 1556067, 4629789, 19366171, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="elongation factor G" /protein_id="NP_387993.2" /db_xref="EnsemblGenomes-Gn:BSU01120" /db_xref="EnsemblGenomes-Tr:CAB11888" /db_xref="GOA:P80868" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004540" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005517" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009022" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035649" /db_xref="PDB:5VH6" /db_xref="SubtiList:BG11939" /db_xref="UniProtKB/Swiss-Prot:P80868" /translation="MAREFSLEKTRNIGIMAHIDAGKTTTTERILFYTGRIHKIGETH EGASQMDWMEQEQERGITITSAATTAQWKGYRVNIIDTPGHVDFTVEVERSLRVLDGA VAVLDAQSGVEPQTETVWRQATTYGVPRIVFVNKMDKIGADFLYSVGTLRDRLQANAH AIQLPIGAEDNFEGIIDLVENVAYFYEDDLGTRSDAKEIPEEYKEQAEELRNSLIEAV CELDEELMDKYLEGEEITIDELKAGIRKGTLNVEFYPVLVGSAFKNKGVQLVLDAVLD YLPAPTDVAAIKGTRPDTNEEIERHSSDEEPFSALAFKVMTDPYVGKLTFFRVYSGTL DSGSYVKNSTKGKRERVGRILQMHANSREEISTVYAGDIAAAVGLKDTTTGDTLCDEK DLVILESMEFPEPVIDVAIEPKSKADQDKMGIALAKLAEEDPTFRTQTNPETGQTIIS GMGELHLDIIVDRMKREFKVEANVGAPQVAYRETFRTGAKVEGKFVRQSGGRGQFGHV WIEFEPNEEGAGFEFENAIVGGVVPREYIPAVQAGLEDALENGVLAGFPLIDIKAKLF DGSYHDVDSNEMAFKVAASMALKNAVSKCNPVLLEPIMKVEVVIPEEYMGDIMGDITS RRGRVEGMEARGNAQVVRAMVPLAEMFGYATALRSNTQGRGTFTMHMDHYEEVPKSVA EEIIKKNKGE*" /label="fusA CDS" gene 130275..132353 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /label="fusA gene" S_feature 132354..132472 /Source="Nicolas_S_feature" /locus_tag="new_132763_132881" /HighExp="T-5.40H, T-4.40H, UNK1, SMM, HiTm, T-3.40H, T-2.40H, SMMPr, MG 90, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S54" CDS 132473..133663 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10774755, 12682299, 7706132, 20133608, 22938038, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10774755, 12682299, 7706132, 20133608, 22938038, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="elongation factor Tu" /protein_id="NP_387994.1" /db_xref="EnsemblGenomes-Gn:BSU01130" /db_xref="EnsemblGenomes-Tr:CAB11889" /db_xref="GOA:P33166" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004160" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004541" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR033720" /db_xref="SubtiList:BG11056" /db_xref="UniProtKB/Swiss-Prot:P33166" /translation="MAKEKFDRSKSHANIGTIGHVDHGKTTLTAAITTVLHKKSGKGT AMAYDQIDGAPEERERGITISTAHVEYETETRHYAHVDCPGHADYVKNMITGAAQMDG AILVVSAADGPMPQTREHILLSKNVGVPYIVVFLNKCDMVDDEELLELVEMEVRDLLS EYDFPGDDVPVVKGSALKALEGDAEWEAKIFELMDAVDEYIPTPERDTEKPFMMPVED VFSITGRGTVATGRVERGQVKVGDEVEIIGLQEENKKTTVTGVEMFRKLLDYAEAGDN IGALLRGVSREEIQRGQVLAKPGTITPHSKFKAEVYVLSKEEGGRHTPFFSNYRPQFY FRTTDVTGIIHLPEGVEMVMPGDNTEMNVELISTIAIEEGTRFSIREGGRTVGSGVVS TITE*" /label="tufA CDS" gene 132473..133663 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /label="tufA gene" downshifts 133658 /Source="Nicolas_upshifts" /id="D48" /incds=0 /nref=258 /ntot=269 /MaxReadThrough="4.84568" /MaxDrop="8.56168" /score="39.3984056" /energy="-12.9" /TU="U88,U90,U94" /idTUdmin="U88" /TUdmin="-1081" /isTUend="FALSE" /label="downshifts" misc_feature complement(133689..133692) /Source="Nicolas_upshift_promotors" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(133693) /Source="Nicolas_upshifts" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 133719..133738 /Source="Nicolas_upshift_promotors" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 133727 /Source="Nicolas_upshifts" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 133762..134718 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /EC_number="3.4.11.5" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proline iminopeptidase" /protein_id="NP_387995.2" /db_xref="EnsemblGenomes-Gn:BSU01140" /db_xref="EnsemblGenomes-Tr:CAB11890" /db_xref="GOA:P70981" /db_xref="InterPro:IPR002410" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11988" /db_xref="UniProtKB/Swiss-Prot:P70981" /translation="MIPEKKSIAIMKELSIGNTKQMLMINGVDVKNPLLLFLHGGPGT PQIGYVRHYQKELEQYFTVVHWDQRGSGLSYSKRISHHSMTINHFIKDTIQVTQWLLA HFSKSKLYLAGHSWGSILALHVLQQRPDLFYTYYGISQVVNPQDEESTAYQHIREISE SKKASILSFLTRFIGAPPWKQDIQHLIYRFCVELTRGGFTHRHRQSLAVLFQMLTGNE YGVRNMHSFLNGLRFSKKHLTDELYRFNAFTSVPSIKVPCVFISGKHDLIVPAEISKQ YYQELEAPEKRWFQFENSAHTPHIEEPSLFANTLSRHARHHL*" /label="ybaC CDS" gene 133762..134718 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /label="ybaC gene" promotor_-35 134725..134732 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 134746..134765 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 134761..134954 /Source="Nicolas_S_feature" /locus_tag="new_135170_135363" /HighExp="T-1.40H, T-2.40H, T-1.10H, SMM, T-3.40H, T-4.40H, BI, BMM, H2O2, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S55" upshifts 134761 /Source="Nicolas_upshifts" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 134955..135263 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 27964882" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 27964882; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S10 (BS13); transcription antitermination factor" /protein_id="NP_387996.1" /db_xref="EnsemblGenomes-Gn:BSU01150" /db_xref="EnsemblGenomes-Tr:CAB11891" /db_xref="GOA:P21471" /db_xref="InterPro:IPR001848" /db_xref="InterPro:IPR018268" /db_xref="InterPro:IPR027486" /db_xref="InterPro:IPR036838" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19008" /db_xref="UniProtKB/Swiss-Prot:P21471" /translation="MAKQKIRIRLKAYDHRILDQSAEKIVETAKRSGASVSGPIPLPT EKSVYTILRAVHKYKDSREQFEMRTHKRLIDIVNPTPQTVDALMRLDLPSGVDIEIKL *" /label="rpsJ CDS" gene 134955..135263 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /label="rpsJ gene" CDS 135303..135932 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 19154332, 23759864" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 19154332, 23759864; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L3 (BL3)" /protein_id="NP_387997.1" /db_xref="EnsemblGenomes-Gn:BSU01160" /db_xref="EnsemblGenomes-Tr:CAB11892" /db_xref="GOA:P42920" /db_xref="InterPro:IPR000597" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR019926" /db_xref="InterPro:IPR019927" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11218" /db_xref="UniProtKB/Swiss-Prot:P42920" /translation="MTKGILGRKIGMTQVFAENGDLIPVTVIEAAPNVVLQKKTAEND GYEAIQLGFDDKREKLSNKPEKGHVAKAETAPKRFVKELRGVEMDAYEVGQEVKVEIF SAGEIVDVTGVSKGKGFQGAIKRHGQSRGPMSHGSRYHRRPGSMGPVDPNRVFKGKLL PGRMGGEQITVQNLEIVKVDAERNLLLIKGNVPGAKKSLITVKSAVKSK*" /label="rplC CDS" gene 135303..135932 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /label="rplC gene" CDS 135960..136583 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10898684, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L4" /protein_id="NP_387998.1" /db_xref="EnsemblGenomes-Gn:BSU01170" /db_xref="EnsemblGenomes-Tr:CAB11893" /db_xref="GOA:P42921" /db_xref="InterPro:IPR002136" /db_xref="InterPro:IPR013005" /db_xref="InterPro:IPR023574" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11219" /db_xref="UniProtKB/Swiss-Prot:P42921" /translation="MPKVALYNQNGSTAGDIELNASVFGIEPNESVVFDAILMQRASL RQGTHKVKNRSEVRGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYSYKLP KKVRRLAIKSVLSSKVIDNNIIVLEDLTLDTAKTKEMAAILKGLSVEKKALIVTADAN EAVALSARNIPGVTVVEANGINVLDVVNHEKLLITKAAVEKVEEVLA*" /label="rplD CDS" gene 135960..136583 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /label="rplD gene" CDS 136583..136870 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L23" /protein_id="NP_387999.2" /db_xref="EnsemblGenomes-Gn:BSU01180" /db_xref="EnsemblGenomes-Tr:CAB11894" /db_xref="GOA:P42924" /db_xref="InterPro:IPR001014" /db_xref="InterPro:IPR012678" /db_xref="InterPro:IPR013025" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11221" /db_xref="UniProtKB/Swiss-Prot:P42924" /translation="MKDPRDVLKRPVITERSADLMTEKKYTFEVDVRANKTEVKDAVE SIFGVKVDKVNIMNYKGKSKRVGRYTGMTSRRRKAIVKLTADSKEIEIFEA*" /label="rplW CDS" gene 136583..136870 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /label="rplW gene" CDS 136902..137735 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23249812, 24637032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23249812, 24637032; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L2 (BL2)" /protein_id="NP_388000.2" /db_xref="EnsemblGenomes-Gn:BSU01190" /db_xref="EnsemblGenomes-Tr:CAB11895" /db_xref="GOA:P42919" /db_xref="InterPro:IPR002171" /db_xref="InterPro:IPR005880" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR014726" /db_xref="InterPro:IPR022666" /db_xref="InterPro:IPR022669" /db_xref="InterPro:IPR022671" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11217" /db_xref="UniProtKB/Swiss-Prot:P42919" /translation="MAIKKYKPTSNGRRGMTTSDFAEITTDKPEKSLLAPLHKKGGRN NQGKLTVRHQGGGHKRQYRVIDFKRDKDGIPGRVATVEYDPNRSANIALINYADGEKR YILAPKGIQVGTEIMSGPEADIKVGNALPLINIPVGTVVHNIELKPGKGGQLVRSAGT SAQVLGKEGKYVLVRLNSGEVRMILSACRASIGQVGNEQHELINIGKAGRSRWKGIRP TVRGSVMNPNDHPHGGGEGRAPIGRKSPMSPWGKPTLGFKTRKKKNKSDKFIVRRRKN K*" /label="rplB CDS" gene 136902..137735 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /label="rplB gene" downshifts complement(137038) /Source="Nicolas_upshifts" /id="D49" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="3.39972" /MaxDrop="4.09052" /score="-4.16840603" /energy="-12.8" /TU="NA" /idTUdmin="U99" /TUdmin=1342 /isTUend="FALSE" /label="downshifts" CDS 137793..138071 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S19 (BS19)" /protein_id="NP_388001.1" /db_xref="EnsemblGenomes-Gn:BSU01200" /db_xref="EnsemblGenomes-Tr:CAB11896" /db_xref="GOA:P21476" /db_xref="InterPro:IPR002222" /db_xref="InterPro:IPR005732" /db_xref="InterPro:IPR020934" /db_xref="InterPro:IPR023575" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19011" /db_xref="UniProtKB/Swiss-Prot:P21476" /translation="MARSLKKGPFVDGHLMTKIEKLNETDKKQVVKTWSRRSTIFPQF IGHTIAVYDGRKHVPVFISEDMVGHKLGEFAPTRTYKGHASDDKKTRR*" /label="rpsS CDS" gene 137793..138071 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /label="rpsS gene" CDS 138088..138429 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7928988, 12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7928988, 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L22 (BL17)" /protein_id="NP_388002.1" /db_xref="EnsemblGenomes-Gn:BSU01210" /db_xref="EnsemblGenomes-Tr:CAB11897" /db_xref="GOA:P42060" /db_xref="InterPro:IPR001063" /db_xref="InterPro:IPR005727" /db_xref="InterPro:IPR018260" /db_xref="InterPro:IPR036394" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11078" /db_xref="UniProtKB/Swiss-Prot:P42060" /translation="MQAKAVARTVRIAPRKARLVMDLIRGKQVGEAVSILNLTPRAAS PIIEKVLKSAIANAEHNYEMDANNLVISQAFVDEGPTLKRFRPRAMGRASQINKRTSH ITIVVSEKKEG*" /label="rplV CDS" gene 138088..138429 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /label="rplV gene" CDS 138433..139089 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S3 (BS3)" /protein_id="NP_388003.2" /db_xref="EnsemblGenomes-Gn:BSU01220" /db_xref="EnsemblGenomes-Tr:CAB11898" /db_xref="GOA:P21465" /db_xref="InterPro:IPR001351" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR005704" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR018280" /db_xref="InterPro:IPR036419" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19005" /db_xref="UniProtKB/Swiss-Prot:P21465" /translation="MGQKVNPVGLRIGVIRDWESKWYAGKDYADFLHEDLKIREYISK RLSDASVSKVEIERAANRVNITIHTAKPGMVIGKGGSEVEALRKALNSLTGKRVHINI LEIKRADLDAQLVADNIARQLENRVSFRRAQKQQIQRTMRAGAQGVKTMVSGRLGGAD IARSEYYSEGTVPLHTLRADIDYATSEADTTYGKLGVKVWIYRGEVLPTKKKNEEGGK *" /label="rpsC CDS" gene 138433..139089 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /label="rpsC gene" downshifts complement(138446) /Source="Nicolas_upshifts" /id="D50" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="3.68388" /MaxDrop="2.1922" /score="-4.16840603" /energy="-12.8" /TU="U99" /idTUdmin="U99" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(138527..138531) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(138534) /Source="Nicolas_upshifts" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(138548..138550) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 139091..139525 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L16" /protein_id="NP_388004.1" /db_xref="EnsemblGenomes-Gn:BSU01230" /db_xref="EnsemblGenomes-Tr:CAB11899" /db_xref="GOA:P14577" /db_xref="InterPro:IPR000114" /db_xref="InterPro:IPR016180" /db_xref="InterPro:IPR020798" /db_xref="InterPro:IPR036920" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10755" /db_xref="UniProtKB/Swiss-Prot:P14577" /translation="MLLPKRVKYRREHRGKMRGRAKGGTEVHFGEFGIQALEASWITN RQIEAARIAMTRYMKRGGKVWIKIFPSKPYTAKPLEVRMGSGKGAPEGWVAVVKPGKV LFEISGVSEEVAREALRLASHKLPIKTKFVKREEIGGESNES*" /label="rplP CDS" gene 139091..139525 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /label="rplP gene" CDS 139515..139715 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L29" /protein_id="NP_388005.1" /db_xref="EnsemblGenomes-Gn:BSU01240" /db_xref="EnsemblGenomes-Tr:CAB11900" /db_xref="GOA:P12873" /db_xref="InterPro:IPR001854" /db_xref="InterPro:IPR018254" /db_xref="InterPro:IPR036049" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10756" /db_xref="UniProtKB/Swiss-Prot:P12873" /translation="MKANEIRDLTTAEIEQKVKSLKEELFNLRFQLATGQLENTARIR EVRKAIARMKTVIREREIAANK*" /label="rpmC CDS" gene 139515..139715 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /label="rpmC gene" CDS 139738..140001 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S17 (BS16)" /protein_id="NP_388006.1" /db_xref="EnsemblGenomes-Gn:BSU01250" /db_xref="EnsemblGenomes-Tr:CAB11901" /db_xref="GOA:P12874" /db_xref="InterPro:IPR000266" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019979" /db_xref="InterPro:IPR019984" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10757" /db_xref="UniProtKB/Swiss-Prot:P12874" /translation="MSERNQRKVYQGRVVSDKMDKTITVVVETYKKHTLYGKRVKYSK KFKAHDENNQAKIGDIVKIMETRPLSATKRFRLVEVVEEAVII*" /label="rpsQ CDS" gene 139738..140001 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /label="rpsQ gene" CDS 140042..140410 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 8805509, 12682299, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 8805509, 12682299, 22829778; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L14" /protein_id="NP_388007.1" /db_xref="EnsemblGenomes-Gn:BSU01260" /db_xref="EnsemblGenomes-Tr:CAB11902" /db_xref="GOA:P12875" /db_xref="InterPro:IPR000218" /db_xref="InterPro:IPR005745" /db_xref="InterPro:IPR019972" /db_xref="InterPro:IPR036853" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10758" /db_xref="UniProtKB/Swiss-Prot:P12875" /translation="MIQQETRLKVADNSGAREVLTIKVLGGSGRKTANIGDVIVCTVK QATPGGVVKKGEVVKAVIVRTKSGARRSDGSYISFDENACVIIRDDKSPRGTRIFGPV ARELRENNFMKIVSLAPEVI*" /label="rplNA CDS" gene 140042..140410 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /label="rplNA gene" CDS 140448..140759 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11278078, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11278078, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L24 (BL23)" /protein_id="NP_388008.1" /db_xref="EnsemblGenomes-Gn:BSU01270" /db_xref="EnsemblGenomes-Tr:CAB11903" /db_xref="GOA:P0CI78" /db_xref="InterPro:IPR003256" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR005825" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10759" /db_xref="UniProtKB/Swiss-Prot:P0CI78" /translation="MHVKKGDKVMVISGKDKGKQGTILAAFPKKDRVLVEGVNMVKKH SKPTQANPQGGISNQEAPIHVSNVMPLDPKTGEVTRVGYKVEDGKKVRVAKKSGQVLD K*" /label="rplX CDS" gene 140448..140759 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /label="rplX gene" CDS 140786..141325 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L5 (BL6)" /protein_id="NP_388009.1" /db_xref="EnsemblGenomes-Gn:BSU01280" /db_xref="EnsemblGenomes-Tr:CAB11904" /db_xref="GOA:P12877" /db_xref="InterPro:IPR002132" /db_xref="InterPro:IPR020929" /db_xref="InterPro:IPR020930" /db_xref="InterPro:IPR022803" /db_xref="InterPro:IPR031309" /db_xref="InterPro:IPR031310" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10760" /db_xref="UniProtKB/Swiss-Prot:P12877" /translation="MNRLKEKYNKEIAPALMTKFNYDSVMQVPKIEKIVINMGVGDAV QNAKAIDSAVEELTFIAGQKPVVTRAKKSIAGFRLREGMPIGAKVTLRGERMYDFLDK LISVSLPRVRDFRGVSKKSFDGRGNYTLGIKEQLIFPEIDYDKVTKVRGMDIVIVTTA NTDEEARELLTQVGMPFQK*" /label="rplE CDS" gene 140786..141325 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /label="rplE gene" CDS 141348..141533 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17163968, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17163968, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S14" /protein_id="NP_388010.1" /db_xref="EnsemblGenomes-Gn:BSU01290" /db_xref="EnsemblGenomes-Tr:CAB11905" /db_xref="GOA:P12878" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023053" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10761" /db_xref="UniProtKB/Swiss-Prot:P12878" /translation="MAKKSMIAKQQRTPKFKVQEYTRCERCGRPHSVIRKFKLCRICF RELAYKGQIPGVKKASW*" /label="rpsNA CDS" gene 141348..141533 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /label="rpsNA gene" CDS 141565..141963 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S8 (BS8)" /protein_id="NP_388011.2" /db_xref="EnsemblGenomes-Gn:BSU01300" /db_xref="EnsemblGenomes-Tr:CAB11906" /db_xref="GOA:P12879" /db_xref="InterPro:IPR000630" /db_xref="InterPro:IPR035987" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10762" /db_xref="UniProtKB/Swiss-Prot:P12879" /translation="MVMTDPIADMLTRIRNANMVRHEKLEIPASKLKREIAEILKREG FIRDVEFVEDSKQGIIRVFLKYGQNNERVITGLKRISKPGLRVYAKSNEVPRVLNGLG IAIISTSQGVLTDKEARAKQAGGEVLAYVW*" /label="rpsH CDS" gene 141565..141963 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /label="rpsH gene" downshifts complement(141966) /Source="Nicolas_upshifts" /id="D51" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="2.68318" /MaxDrop="2.55712" /score="5.40276403" /energy="-15.9" /TU="NA" /idTUdmin="U99" /TUdmin="-3586" /isTUend="FALSE" /label="downshifts" CDS 141993..142532 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 25330043; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L6 (BL8)" /protein_id="NP_388012.1" /db_xref="EnsemblGenomes-Gn:BSU01310" /db_xref="EnsemblGenomes-Tr:CAB11907" /db_xref="GOA:P46898" /db_xref="InterPro:IPR000702" /db_xref="InterPro:IPR002358" /db_xref="InterPro:IPR019906" /db_xref="InterPro:IPR020040" /db_xref="InterPro:IPR036789" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11408" /db_xref="UniProtKB/Swiss-Prot:P46898" /translation="MSRVGKKLLEIPSDVTVTLNDNNTVAVKGPKGELTRTFHPDMEI KVEDNVLTVARPSDQKEHRALHGTTRSLLGNMVEGVSKGFERGLELVGVGYRASKSGN KLVLNVGYSHPVEIVPEEGIEIEVPSQTKVVVKGTDKERVGAIAANIRAVRSPEPYKG KGIRYEGEVVRRKEGKSAK*" /label="rplF CDS" gene 141993..142532 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /label="rplF gene" CDS 142565..142927 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L18" /protein_id="NP_388013.2" /db_xref="EnsemblGenomes-Gn:BSU01320" /db_xref="EnsemblGenomes-Tr:CAB11908" /db_xref="GOA:P46899" /db_xref="InterPro:IPR004389" /db_xref="InterPro:IPR005484" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11409" /db_xref="UniProtKB/Swiss-Prot:P46899" /translation="MITKTSKNAARLKRHARVRAKLSGTAERPRLNVFRSNKHIYAQI IDDVNGVTLASASTLDKDLNVESTGDTSAATKVGELVAKRAAEKGISDVVFDRGGYLY HGRVKALADAAREAGLKF*" /label="rplR CDS" gene 142565..142927 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /label="rplR gene" CDS 142952..143452 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6211592, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6211592, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S5" /protein_id="NP_388014.1" /db_xref="EnsemblGenomes-Gn:BSU01330" /db_xref="EnsemblGenomes-Tr:CAB11909" /db_xref="GOA:P21467" /db_xref="InterPro:IPR000851" /db_xref="InterPro:IPR005324" /db_xref="InterPro:IPR005712" /db_xref="InterPro:IPR013810" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018192" /db_xref="InterPro:IPR020568" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10442" /db_xref="UniProtKB/Swiss-Prot:P21467" /translation="MRRIDPSKLELEERLVTVNRVAKVVKGGRRFRFAALVVVGDKNG HVGFGTGKAQEVPEAIRKAVEDAKKNLIEVPMVGTTIPHEIIGRFGAGNILLKPASEG TGVIAGGPVRAVLELAGVADILSKSLGSNTPINMIRATLQGLSELKRAEDVAKLRGKS VEELLG*" /label="rpsE CDS" gene 142952..143452 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /label="rpsE gene" CDS 143466..143645 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L30 (BL27)" /protein_id="NP_388015.1" /db_xref="EnsemblGenomes-Gn:BSU01340" /db_xref="EnsemblGenomes-Tr:CAB11910" /db_xref="GOA:P19947" /db_xref="InterPro:IPR005996" /db_xref="InterPro:IPR016082" /db_xref="InterPro:IPR018038" /db_xref="InterPro:IPR036919" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10443" /db_xref="UniProtKB/Swiss-Prot:P19947" /translation="MAKLEITLKRSVIGRPEDQRVTVRTLGLKKTNQTVVHEDNAAIR GMINKVSHLVSVKEQ*" /label="rpmD CDS" gene 143466..143645 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /label="rpmD gene" CDS 143676..144116 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15855514, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15855514, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L15" /protein_id="NP_388016.1" /db_xref="EnsemblGenomes-Gn:BSU01350" /db_xref="EnsemblGenomes-Tr:CAB11911" /db_xref="GOA:P19946" /db_xref="InterPro:IPR001196" /db_xref="InterPro:IPR005749" /db_xref="InterPro:IPR021131" /db_xref="InterPro:IPR030878" /db_xref="InterPro:IPR036227" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10444" /db_xref="UniProtKB/Swiss-Prot:P19946" /translation="MKLHELKPSEGSRKTRNRVGRGIGSGNGKTAGKGHKGQNARSGG GVRPGFEGGQMPLFQRLPKRGFTNINRKEYAVVNLDKLNGFAEGTEVTPELLLETGVI SKLNAGVKILGNGKLEKKLTVKANKFSASAKEAVEAAGGTAEVI*" /label="rplO CDS" gene 143676..144116 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /label="rplO gene" CDS 144118..145413 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478; Product type t: transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_388017.1" /db_xref="EnsemblGenomes-Gn:BSU01360" /db_xref="EnsemblGenomes-Tr:CAB11912" /db_xref="GOA:P16336" /db_xref="InterPro:IPR002208" /db_xref="InterPro:IPR023201" /db_xref="InterPro:IPR026593" /db_xref="InterPro:IPR030659" /db_xref="SubtiList:BG10445" /db_xref="UniProtKB/Swiss-Prot:P16336" /translation="MFKTISNFMRVSDIRNKIIFTLLMLIVFRIGAFIPVPYVNAEAL QAQSQMGVFDLLNTFGGGALYQFSIFAMGITPYITASIIIQLLQMDVVPKFTEWSKQG EVGRRKLAQFTRYFTIVLGFIQALGMSYGFNNLANGMLIEKSGVSTYLIIALVLTGGT AFLMWLGEQITSHGVGNGISIIIFAGIVSSIPKTIGQIYETQFVGSNDQLFIHIVKVA LLVIAILAVIVGVIFIQQAVRKIAIQYAKGTGRSPAGGGQSTHLPLKVNPAGVIPVIF AVAFLITPRTIASFFGTNDVTKWIQNNFDNTHPVGMAIYVALIIAFTYFYAFVQVNPE QMADNLKKQGGYIPGVRPGKMTQDRITSILYRLTFVGSIFLAVISILPIFFIQFAGLP QSAQIGGTSLLIVVGVALETMKQLESQLVKRNYRGFMKN*" /label="secY CDS" gene 144118..145413 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /label="secY gene" CDS 145468..146121 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /EC_number="2.7.4.3" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8061005, 8288548, 9056261, 9715904, 11106368, 16452168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8061005, 8288548, 9056261, 9715904, 11106368, 16452168; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate kinase" /protein_id="NP_388018.1" /db_xref="EnsemblGenomes-Gn:BSU01370" /db_xref="EnsemblGenomes-Tr:CAB11913" /db_xref="GOA:P16304" /db_xref="InterPro:IPR000850" /db_xref="InterPro:IPR006259" /db_xref="InterPro:IPR007862" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033690" /db_xref="PDB:1P3J" /db_xref="PDB:2EU8" /db_xref="PDB:2OO7" /db_xref="PDB:2ORI" /db_xref="PDB:2OSB" /db_xref="PDB:2P3S" /db_xref="PDB:2QAJ" /db_xref="PDB:3DKV" /db_xref="PDB:3DL0" /db_xref="PDB:4MKF" /db_xref="PDB:4MKG" /db_xref="PDB:4MKH" /db_xref="PDB:4QBF" /db_xref="PDB:4QBG" /db_xref="PDB:4TYP" /db_xref="PDB:4TYQ" /db_xref="SubtiList:BG10446" /db_xref="UniProtKB/Swiss-Prot:P16304" /translation="MNLVLMGLPGAGKGTQGERIVEDYGIPHISTGDMFRAAMKEETP LGLEAKSYIDKGELVPDEVTIGIVKERLGKDDCERGFLLDGFPRTVAQAEALEEILEE YGKPIDYVINIEVDKDVLMERLTGRRICSVCGTTYHLVFNPPKTPGICDKDGGELYQR ADDNEETVSKRLEVNMKQTQPLLDFYSEKGYLANVNGQQDIQDVYADVKDLLGGLKK* " /label="adk CDS" gene 145468..146121 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /label="adk gene" CDS 146118..146864 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16207374, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase" /protein_id="NP_388019.1" /db_xref="EnsemblGenomes-Gn:BSU01380" /db_xref="EnsemblGenomes-Tr:CAB11914" /db_xref="GOA:P19994" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG10447" /db_xref="UniProtKB/Swiss-Prot:P19994" /translation="MIICKTPRELGIMREAGRIVALTHEELKKHIKPGISTKELDQIA ERFIKKQGAIPSFKGYNGFRGSICVSVNEELVHGIPGSRVLKDGDIISIDIGAKLNGY HGDSAWTYPVGNISDDDKKLLEVTEESLYKGLQEAKPGERLSNISHAIQTYVENEQFS VVREYVGHGVGQDLHEDPQIPHYGPPNKGPRLKPGMVLAIEPMVNAGSRYVKTLADNW TVVTVDGKKCAHFEHTIAITETGFDILTRV*" /label="mapA CDS" gene 146118..146864 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /label="mapA gene" CDS 146903..147127 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17157877; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative ribosome binding protein" /protein_id="YP_003097669.1" /db_xref="EnsemblGenomes-Gn:BSU01389" /db_xref="EnsemblGenomes-Tr:CAX52539" /db_xref="UniProtKB/Swiss-Prot:C0H3S8" /translation="MIGQKAWVNIGKTEFILLLVVGILTIINVLTADGEKRTFHSPKK KNINHLTLYDCVSPEVQNSINETGRVTNFF*" /label="ybzG CDS" gene 146903..147127 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /label="ybzG gene" CDS 147176..147394 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9868784, 20477873, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-I" /protein_id="NP_388020.1" /db_xref="EnsemblGenomes-Gn:BSU01390" /db_xref="EnsemblGenomes-Tr:CAB11915" /db_xref="GOA:P20458" /db_xref="InterPro:IPR004368" /db_xref="InterPro:IPR006196" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11043" /db_xref="UniProtKB/Swiss-Prot:P20458" /translation="MAKDDVIEVEGTIVETLPNAMFKVELENGHTVLAHVSGKIRMHF IRILPGDKVTVELSPYDLTRGRITYRYK*" /label="infA CDS" gene 147176..147394 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /label="infA gene" CDS 147428..147541 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1783905, 23002217, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1783905, 23002217, 24335279; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L36 (ribosomal protein B)" /protein_id="NP_388021.1" /db_xref="EnsemblGenomes-Gn:BSU01400" /db_xref="EnsemblGenomes-Tr:CAB11916" /db_xref="GOA:P20278" /db_xref="InterPro:IPR000473" /db_xref="InterPro:IPR035977" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11042" /db_xref="UniProtKB/Swiss-Prot:P20278" /translation="MKVRPSVKPICEKCKVIRRKGKVMVICENPKHKQKQG*" /label="rpmJ CDS" gene 147428..147541 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /label="rpmJ gene" CDS 147564..147929 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S13" /protein_id="NP_388022.2" /db_xref="EnsemblGenomes-Gn:BSU01410" /db_xref="EnsemblGenomes-Tr:CAB11917" /db_xref="GOA:P20282" /db_xref="InterPro:IPR001892" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR018269" /db_xref="InterPro:IPR019980" /db_xref="InterPro:IPR027437" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10730" /db_xref="UniProtKB/Swiss-Prot:P20282" /translation="MARIAGVDIPRDKRVVISLTYIFGIGRTTAQQVLKEAGVSEDTR VRDLTEEELGKIRDIIDKLKVEGDLRREVSLNIKRLIEIGSYRGIRHRRGLPVRGQNS KNNARTRKGPRRTVANKKK*" /label="rpsM CDS" gene 147564..147929 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /label="rpsM gene" CDS 147950..148345 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217780, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217780, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S11 (BS11)" /protein_id="NP_388023.1" /db_xref="EnsemblGenomes-Gn:BSU01420" /db_xref="EnsemblGenomes-Tr:CAB11918" /db_xref="GOA:P04969" /db_xref="InterPro:IPR001971" /db_xref="InterPro:IPR018102" /db_xref="InterPro:IPR019981" /db_xref="InterPro:IPR036967" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10731" /db_xref="UniProtKB/Swiss-Prot:P04969" /translation="MAAARKSNTRKRRVKKNIESGIAHIRSTFNNTIVTITDTHGNAI SWSSAGALGFRGSRKSTPFAAQMAAETAAKGSIEHGLKTLEVTVKGPGSGREAAIRAL QAAGLEVTAIRDVTPVPHNGCRPPKRRRV*" /label="rpsK CDS" gene 147950..148345 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /label="rpsK gene" S_feature 148346..148521 /Source="Nicolas_S_feature" /locus_tag="new_148755_148930" /HighExp="G135, dia5, Lbexp, S0, aero, dia0, T-4.40H, G150, Paraq, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S56" CDS 148522..149466 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1484484, 6811591, 9594570, 10972808, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1484484, 6811591, 9594570, 10972808, 12682299, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (alpha subunit)" /protein_id="NP_388024.1" /db_xref="EnsemblGenomes-Gn:BSU01430" /db_xref="EnsemblGenomes-Tr:CAB11919" /db_xref="GOA:P20429" /db_xref="InterPro:IPR011260" /db_xref="InterPro:IPR011262" /db_xref="InterPro:IPR011263" /db_xref="InterPro:IPR011773" /db_xref="InterPro:IPR036603" /db_xref="InterPro:IPR036643" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG10732" /db_xref="UniProtKB/Swiss-Prot:P20429" /translation="MIEIEKPKIETVEISDDAKFGKFVVEPLERGYGTTLGNSLRRIL LSSLPGAAVTSIQIDGVLHEFSTIEGVVEDVTTIILHIKKLALKIYSDEEKTLEIDVQ GEGTVTAADITHDSDVEILNPDLHIATLGENASFRVRLTAQRGRGYTPADANKRDDQP IGVIPIDSIYTPVSRVSYQVENTRVGQVANYDKLTLDVWTDGSTGPKEAIALGSKILT EHLNIFVGLTDEAQHAEIMVEKEEDQKEKVLEMTIEELDLSVRSYNCLKRAGINTVQE LANKTEEDMMKVRNLGRKSLEEVKAKLEELGLGLRKDD*" /label="rpoA CDS" gene 148522..149466 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /label="rpoA gene" CDS 149544..149906 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6801428, 10717392, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6801428, 10717392, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L17 (BL15)" /protein_id="NP_388025.1" /db_xref="EnsemblGenomes-Gn:BSU01440" /db_xref="EnsemblGenomes-Tr:CAB11920" /db_xref="GOA:P20277" /db_xref="InterPro:IPR000456" /db_xref="InterPro:IPR036373" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11041" /db_xref="UniProtKB/Swiss-Prot:P20277" /translation="MSYRKLGRTSAQRKAMLRDLTTDLIINERIETTETRAKELRSVV EKMITLGKRGDLHARRQAAAYIRNEVANEENNQDALQKLFSDIATRYEERQGGYTRIM KLGPRRGDGAPMAIIELV*" /label="rplQ CDS" gene 149544..149906 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /label="rplQ gene" downshifts 149908 /Source="Nicolas_upshifts" /id="D52" /incds=0 /nref=171 /ntot=259 /MaxReadThrough="7.50771" /MaxDrop="5.4374" /score="2.32634618" /energy="-10.5" /TU="U98" /idTUdmin="U98" /TUdmin="-5577" /isTUend="FALSE" /label="downshifts" S_feature 149953..150033 /Source="Nicolas_S_feature" /locus_tag="new_150362_150442" /HighExp="Cold, G180, G135, G150, H2O2, S0, C30, Oxctl, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S57" CDS 150034..150879 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388026.2" /db_xref="EnsemblGenomes-Gn:BSU01450" /db_xref="EnsemblGenomes-Tr:CAB11921" /db_xref="GOA:P40735" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030947" /db_xref="SubtiList:BG11067" /db_xref="UniProtKB/Swiss-Prot:P40735" /translation="MNQNQLISVEDIVFRYRKDAERRALDGVSLQVYEGEWLAIVGHN GSGKSTLARALNGLILPESGDIEVAGIQLTEESVWEVRKKIGMVFQNPDNQFVGTTVR DDVAFGLENNGVPREEMIERVDWAVKQVNMQDFLDQEPHHLSGGQKQRVAIAGVIAAR PDIIILDEATSMLDPIGREEVLETVRHLKEQGMATVISITHDLNEAAKADRIIVMNGG KKYAEGPPEEIFKLNKELVRIGLDLPFSFQLSQLLRENGLALEENHLTQEGLVKELWT LQSKM*" /label="ecfA CDS" gene 150034..150879 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /label="ecfA gene" CDS 150894..151724 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12110480, 21135102, 26052893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388027.1" /db_xref="EnsemblGenomes-Gn:BSU01460" /db_xref="EnsemblGenomes-Tr:CAB11922" /db_xref="GOA:P70970" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030946" /db_xref="SubtiList:BG11989" /db_xref="UniProtKB/Swiss-Prot:P70970" /translation="MKTPFERLALYDINASIKEGSYVAVIGHTGSGKSTLLQHLNGLL KPTKGQISLGSTVIQAGKKNKDLKKLRKKVGIVFQFPEHQLFEETVLKDISFGPMNFG VKKEDAEQKAREMLQLVGLSEELLDRSPFELSGGQMRRVAIAGVLAMDPEVLVLDEPT AGLDPRGRKEIMDMFYELHQRGNLTTILVTHSMEDAAAYADEMIVMHKGTIQASGSPR DLFLKGEEMAGWGLDLPETIKFQRHLEAALGVRFNEPMLTIEDAAAEIRALFQGEKTL *" /label="ecfAB CDS" gene 150894..151724 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /label="ecfAB gene" CDS 151721..152518 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 18931129, 21135102, 26052893; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the influx ECF transporters" /protein_id="NP_388028.2" /db_xref="EnsemblGenomes-Gn:BSU01470" /db_xref="EnsemblGenomes-Tr:CAB11923" /db_xref="GOA:P70972" /db_xref="InterPro:IPR003339" /db_xref="InterPro:IPR024919" /db_xref="SubtiList:BG11990" /db_xref="UniProtKB/Swiss-Prot:P70972" /translation="MMDSMIIGKYVPGTSLVHRLDPRTKLITIFLFVCIVFLANNVQT YALLGLFTIGVVSLTRVPFSFLMKGLKPIIWIVLFTFLLHILMTHEGPIIFQIGFFKV YEGGLVQGIFISLRFVYLILITTLLTLTTTPIEITDGMEQLLNPLKKLKLPVHELALM MSISLRFIPTLMEETDKIMKAQMARGVDFTSGPVKERVKAIVPLLVPLFVSAFKRAEE LAVAMEARGYQGGEGRTKYRKLVWTGKDTSVIVSLIVLAALLFFLRA*" /label="ecfT CDS" gene 151721..152518 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /label="ecfT gene" CDS 152528..153271 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /EC_number="5.4.99.12" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10529181, 15353568, 17114947, 17466622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine (38-40) synthase" /protein_id="NP_388029.2" /db_xref="EnsemblGenomes-Gn:BSU01480" /db_xref="EnsemblGenomes-Tr:CAB11924" /db_xref="GOA:P70973" /db_xref="InterPro:IPR001406" /db_xref="InterPro:IPR020095" /db_xref="InterPro:IPR020097" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG11992" /db_xref="UniProtKB/Swiss-Prot:P70973" /translation="MRLKCTISYDGHLFNGYQVQPGKRTVQDELEKALAVLHKSKDRI PVVSSGRTDSGVHAAGQVIHFDTPLSIPAERWPYALNALLPDDIAVKQAEIADDGFHA RFSAVKKEYRYFVYTEKHPDVFKRHYAYHFSYRLNVQDMREAAKHLIGTHDFTSFCAA KTEVQDKVRTIYELDWTETADGLQMRITGSGFLYNMVRIIAGTLLDAGIGKISPDEVK SMLEAKDREAAGRTAPGHGLYLWNVYYDN*" /label="truA CDS" gene 152528..153271 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /label="truA gene" S_feature complement(152630..153098) /Source="Nicolas_S_feature" /locus_tag="new_153039_153507_c" /HighExp="S6, S8, S7, C30, G135, BT, S5, C90, M/G, Pyr" /AntisenseName="truA" /AntisenseCor="-0.30232258010971202" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S58" promotor_-35 152763..152768 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 152783..152800 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 152802 /Source="Nicolas_upshifts" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(153098..153117) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(153120) /Source="Nicolas_upshifts" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(153130..153139) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 153291..153297 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 153312..153331 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 153316 /Source="Nicolas_upshifts" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 153328..153384 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /product="putative L13_leader" /note="Evidence 3: Putative function from multiple computational evidences; Product type n: RNA" /label="ldlM RNA" gene 153328..153384 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /label="ldlM gene" CDS 153433..153870 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 23504016, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 23504016, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L13" /protein_id="NP_388030.2" /db_xref="EnsemblGenomes-Gn:BSU01490" /db_xref="EnsemblGenomes-Tr:CAB11925" /db_xref="GOA:P70974" /db_xref="InterPro:IPR005822" /db_xref="InterPro:IPR005823" /db_xref="InterPro:IPR023563" /db_xref="InterPro:IPR036899" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11970" /db_xref="UniProtKB/Swiss-Prot:P70974" /translation="MRTTPMANASTIERKWLVVDAAGKTLGRLSSEVAAILRGKHKPT YTPHVDTGDHVIIINAEKIELTGKKLTDKIYYRHTQHPGGLKSRTALEMRTNYPEKML ELAIKGMLPKGSLGRQMFKKLNVYRGSEHPHEAQKPEVYELRG*" /label="rplM CDS" gene 153433..153870 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /label="rplM gene" CDS 153891..154283 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 19653700, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S9" /protein_id="NP_388031.1" /db_xref="EnsemblGenomes-Gn:BSU01500" /db_xref="EnsemblGenomes-Tr:CAB11926" /db_xref="GOA:P21470" /db_xref="InterPro:IPR000754" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020574" /db_xref="InterPro:IPR023035" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19007" /db_xref="UniProtKB/Swiss-Prot:P21470" /translation="MAQVQYYGTGRRKSSVARVRLVPGEGRIVVNNREISEHIPSAAL IEDIKQPLTLTETAGTYDVLVNVHGGGLSGQAGAIRHGIARALLEADPEYRTTLKRAG LLTRDARMKERKKYGLKGARRAPQFSKR*" /label="rpsI CDS" gene 153891..154283 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /label="rpsI gene" downshifts 154258 /Source="Nicolas_upshifts" /id="D53" /incds=0 /nref=262 /ntot=282 /MaxReadThrough="4.65387" /MaxDrop="8.11906" /score="30.5093496" /energy="-13.3" /TU="U98,U100,U102" /idTUdmin="U98" /TUdmin="-1227" /isTUend="FALSE" /label="downshifts" promotor_-35 154400..154407 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 154421..154440 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 154429..154710 /Source="Nicolas_S_feature" /locus_tag="new_154838_155119" /HighExp="H2O2, G180, G135, Paraq, Diami, dia15, Oxctl, Cold, Heat, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.479, 1" /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S59" upshifts 154429 /Source="Nicolas_upshifts" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" misc_feature 154709..154728 /Source="Nicolas_upshift_promotors" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 154712 /Source="Nicolas_upshifts" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 154747..155514 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26582911; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388032.2" /db_xref="EnsemblGenomes-Gn:BSU01510" /db_xref="EnsemblGenomes-Tr:CAB11927" /db_xref="GOA:P70976" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11994" /db_xref="UniProtKB/Swiss-Prot:P70976" /translation="MNALVAHNSKAWDKKVETGNEWTVAVEQQVIEQAKKGNWDIRVT PMKDVPKDWFPPIKGLKVLCLASGGGQQGPVLAAAGADVTVLDNSEKQLNQDRMIAER DGLTIHTVKGSMDDLSVFNDESFDVIVHPVANVFVENVLPVWKEAYRVLKRNGILISG FVNPVVFLFDTELEQQGVLKVKHSIPYADPEDLPKHKVKKLIENNEALEFGHSLEDQI KGQIDAGFIVTGFYEDKGGFVLDQYIHTYSATRSVKV*" /label="ybaJ CDS" gene 154747..155514 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /label="ybaJ gene" downshifts 155505 /Source="Nicolas_upshifts" /id="D54" /incds=0 /nref=215 /ntot=251 /MaxReadThrough="2.69346" /MaxDrop="6.09641" /score="4.42269359" /energy="-10.3" /TU="NA" /idTUdmin="U100" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 155644..155650 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 155665..155676 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 155672 /Source="Nicolas_upshifts" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="upshifts" CDS 155700..156143 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679227, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388033.1" /db_xref="EnsemblGenomes-Gn:BSU01520" /db_xref="EnsemblGenomes-Tr:CAB11928" /db_xref="GOA:P50862" /db_xref="InterPro:IPR019667" /db_xref="SubtiList:BG11503" /db_xref="UniProtKB/Swiss-Prot:P50862" /translation="MAEVLSFMDVKRQKDFELEKNLLKELSLRQIIQSVKDCLEPLFP FLHDERDIITEGCIDFAIEAYLLGGRFGIFGYYGESMQSISARSAREEEELRMEFFDY LYNWIHEQYATFDKNTVYEAARKFIKDWWTAGFVQREKQCKLRMR*" /label="ybaK CDS" gene 155700..156143 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /label="ybaK gene" promotor_-35 156143..156148 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 156164..156182 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 156165 /Source="Nicolas_upshifts" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="upshifts" CDS 156203..156916 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /EC_number="3.5.1.28" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_388034.1" /db_xref="EnsemblGenomes-Gn:BSU01530" /db_xref="EnsemblGenomes-Tr:CAB11929" /db_xref="GOA:P50864" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR014234" /db_xref="SubtiList:BG11514" /db_xref="UniProtKB/Swiss-Prot:P50864" /translation="MRKKLKWLSFLLGFIILLFLFKYQFSNNDSWKPWSLPLSGKIIY LDPGHGGPDGGAVGGKLLEKDVTLEVAFRVRDYLQEQGALVIMTRESDTDLAPEGTKG YSRRKAEDLRQRVKLINHSEAELYISIHLNAIPSQKWSGAQSFYYGKYAENEKVAKYI QDELRRNLENTTRKAKRIHGIYLMQNVTKPGALIEVGFLSNPSEATLLGKPKYQDKVA SSIYKGILRYFTEKGDPPE*" /label="cwlD CDS" gene 156203..156916 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /label="cwlD gene" upshifts 156961 /Source="Nicolas_upshifts" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="upshifts" misc_feature 156964..156983 /Source="Nicolas_upshift_promotors" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 157012..158070 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11790741, 15126467, 26094643" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11790741, 15126467, 26094643; Product type r: regulator" /codon_start=1 /transl_table=11 /product="phosphorylation-dependent (Y327) transcriptionalregulator" /protein_id="NP_388035.1" /db_xref="EnsemblGenomes-Gn:BSU01540" /db_xref="EnsemblGenomes-Tr:CAB11930" /db_xref="GOA:P50863" /db_xref="InterPro:IPR000808" /db_xref="InterPro:IPR019591" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033756" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG11494" /db_xref="UniProtKB/Swiss-Prot:P50863" /translation="MIREDEVRKLVGEMREPFLQRPLGELDAVKEIKIKPEKRHISVK VALAKTGTAEQMQIQQEIVNVLKGAGAETVGLRFEELPEETVAKFRAPSAEKKTLLNM DNPPVFLAVASGKGGVGKSTVSVNLAISLARLGKKVGLIDADIYGFSVPDMMGITVRP TIEGEKLLPVERFGVKVMSMGFFVEENAPVVWRGPMLGKMLNNFFHEVEWGEVDYIVL DLPPGTGDVALDVHTMLPSCKEIIVSTPHPTAAFVAARAGSMAIKTDHEVVGVIENMA YYESAKTGEREYVFGKGGGDKLAEELNVPLLGRIPLKQPDWDKDQFAPSVYDENHPIG EIYQDIAKKIDAKMSVQV*" /label="salA CDS" gene 157012..158070 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /label="salA gene" S_feature complement(157641..158105) /Source="Nicolas_S_feature" /locus_tag="new_158050_158514_c" /HighExp="S8, S7, S6, S5, C30, S4, C90, nit, ferm, Gly" /AntisenseName="salA" /AntisenseCor="-0.104183954485248" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S60" downshifts 158056 /Source="Nicolas_upshifts" /id="D55" /incds=0 /nref=29 /ntot=155 /MaxReadThrough="5.44939" /MaxDrop="4.18382" /score="-4.46878413" /energy="-9.1" /TU="U107" /idTUdmin="U106" /TUdmin=1185 /isTUend="FALSE" /label="downshifts" S_feature 158101..158772 /Source="Nicolas_S_feature" /locus_tag="new_158510_159181" /HighExp="Lbtran, H2O2, Cold, Lbstat, dia5, M40t45, M0t90, M40t90, T0.30H, S1" /AntisenseName="gerD" /AntisenseCor="-0.24235509346425901" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S61" CDS complement(158106..158663) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17122337, 10618233, 10376819, 24530795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17122337, 10618233, 10376819, 24530795; Product type f: factor" /codon_start=1 /transl_table=11 /product="lipoprotein factor mediating clustering of germination proteins" /protein_id="NP_388036.1" /db_xref="EnsemblGenomes-Gn:BSU01550" /db_xref="EnsemblGenomes-Tr:CAB11931" /db_xref="GOA:P16450" /db_xref="SubtiList:BG10644" /db_xref="UniProtKB/Swiss-Prot:P16450" /translation="MSKAKTLLMSCFLLLSVTACAPKDQAADMDYDQTKKMVVDILKT DDGKKAIKELLNDDAMNEALVIDQDAIKGTIEKTLTSKKGEEFWKNIFEDTDFAEGFA KTLQTEHEKVIKKLMKDPDYQKMLMSVMQDPGMDKKYSQLAKSQEFRSYLEEVINETL SSPLYKKQFEDELKKAAKDTAKESE*" /label="gerD CDS" gene complement(158106..158663) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /label="gerD gene" promotor_-10 complement(158695..158706) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(158707) /Source="Nicolas_upshifts" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(158720..158726) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(158740..159369) /Source="Nicolas_S_feature" /locus_tag="new_159149_159778_c" /HighExp="S3, T5.0H, S4, S8, M9-stat, T4.0H, T3.30H, S7, T3.0H, S6" /AntisenseName="kbaA" /AntisenseCor="7.9344921760152495E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S62" CDS 158773..159369 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8576055, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576055, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inner membrane protein involved in activation ofthe KinB signaling pathway to sporulation" /protein_id="NP_388037.1" /db_xref="EnsemblGenomes-Gn:BSU01560" /db_xref="EnsemblGenomes-Tr:CAB11932" /db_xref="GOA:P16449" /db_xref="InterPro:IPR024164" /db_xref="SubtiList:BG10643" /db_xref="UniProtKB/Swiss-Prot:P16449" /translation="MKSRGLVRFFFSILAVGALITSIVGFALKWGEYRGLFLTFEAGQ IFSVLFWFIGVGMIFSVISQMGFFVFLTVHRFALEILRSSSLWNLLQLFFILFVAFDL MYVRFLFFGESGESLAGYAWLPVFLLIFGVITAYIKQKQSSKKTFVSSLFLMVVITAL EWFPALRVNDEDWLYLMLFPLMACNAFQLLMLPKFAAK*" /label="kbaA CDS" gene 158773..159369 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /label="kbaA gene" S_feature 159370..160264 /Source="Nicolas_S_feature" /locus_tag="new_159779_160673" /HighExp="Lbstat, Lbtran, M0t90, M40t90, H2O2, BC, Glucon, S7, M40t45, S1" /AntisenseName="ybaN" /AntisenseCor="-2.6735901031407501E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S63" CDS complement(159370..160134) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 15598884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 15598884; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="polysaccharide deacetylase involved in sporulation" /protein_id="NP_388038.1" /db_xref="EnsemblGenomes-Gn:BSU01570" /db_xref="EnsemblGenomes-Tr:CAB11933" /db_xref="GOA:P50865" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014132" /db_xref="SubtiList:BG11416" /db_xref="UniProtKB/Swiss-Prot:P50865" /translation="MNHFYVWHIKRVKQLIIILIAAFAAASFFYIQRAVPLPVFSTDT GPKAIYKGETDSKDISLTFDISWGDERAEPILNTLKANGIKNATFFLSASWAERHPDT VARIVKDGHQIGSMGYAYKNYANLESSEIKKDMNRAQTAFEKLGVKDIQLLRPPTGQF NKNVLKVAKQYNYTVVHYSVNSQDWTNPGVEKIIDNVTKQVSGGDIILLHASDSAKQT EEALPDIIHQLKEKGLKNVTVGDLIANSDAKSAEVK*" /label="pdaB CDS" gene complement(159370..160134) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /label="pdaB gene" promotor_-10 complement(160165..160183) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(160185) /Source="Nicolas_upshifts" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(160199..160204) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 160242..160249 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 160264..160283 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 160266..160483 /Source="Nicolas_S_feature" /locus_tag="new_160675_160892" /HighExp="Diami, LBGstat, UNK1, H2O2, MG 15, Oxctl, MG-0.1, BMM, T-1.10H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S64" upshifts 160266 /Source="Nicolas_upshifts" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="upshifts" rRNA 160484..162037 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-16S rRNA" gene 160484..162037 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /modified_by="User" /label="rrnI-16S gene" Polymorphism join(160830,160832) /Source="geneious" /ID="SNP_BsDelta6_161240_161239" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="C" /Codon_Change /Coverage=45 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="C" /Variant_P_Value="4.2e-57" /Variant_Raw_Frequency=41 /comment="rrnI-16S rRNA" /modified_by="User" / /label="Polymorphism_Delta6" rRNA 162202..165129 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-23S rRNA" gene 162202..165129 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /label="rrnI-23S gene" rRNA 165185..165301 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /product="ribosomal RNA-5S" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-5S rRNA" gene 165185..165301 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /label="rrnI-5S gene" Polymorphism join(165341,165342) /Source="geneious" /ID="SNP_BsDelta6_165748_165749" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=2 /Amino_Acid_Change /CDS_Position /Change="-TC" /Codon_Change /Coverage="172 -> 174" /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="TC" /Variant_Nucleotides /Variant_P_Value="1.5e-307" /Variant_Raw_Frequency=152 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(165342,165344) /Source="geneious" /ID="SNP_BsDelta6_165751_165751" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="C -> T" /Codon_Change /Coverage=172 /locus_tag /Protein_Effect /Reference_Frequency="1.2%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=168 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165346..165417 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Asn tRNA" gene 165346..165417 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /label="trnI-Asn gene" Polymorphism join(165417,165419) /Source="geneious" /ID="SNP_BsDelta6_165826_165825" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="C" /Codon_Change /Coverage=163 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=160 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165423..165495 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(GGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Thr tRNA" gene 165423..165495 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /label="trnI-Thr gene" tRNA 165552..165626 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Gly tRNA" gene 165552..165626 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /label="trnI-Gly gene" Polymorphism join(165630,165632) /Source="geneious" /ID="SNP_BsDelta6_166038_166037" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="T" /Codon_Change /Coverage=154 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=148 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165658..165734 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg(AGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Arg tRNA" gene 165658..165734 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /label="trnI-Arg gene" tRNA 165762..165838 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Pro tRNA" gene 165762..165838 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /label="trnI-Pro gene" tRNA 165847..165922 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Ala tRNA" gene 165847..165922 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /label="trnI-Ala gene" Polymorphism join(165937,165938) /Source="geneious" /ID="SNP_BsDelta6_166344_166344" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-G" /Codon_Change /Coverage=132 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides /Variant_P_Value="4.9e-75" /Variant_Raw_Frequency=130 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" rRNA 166093..167646 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-16S rRNA" gene 166093..167646 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /label="rrnH-16S gene" rRNA 167811..170738 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-23S rRNA" gene 167811..170738 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /label="rrnH-23S gene" rRNA 170794..170911 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-5S rRNA" gene 170794..170911 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /label="rrnH-5S gene" rRNA 171095..172648 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-16S rRNA" gene 171095..172648 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /label="rrnG-16S gene" rRNA 172813..175740 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-23S rRNA" gene 172813..175740 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /label="rrnG-23S gene" rRNA 175796..175914 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-5S rRNA" gene 175796..175914 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /label="rrnG-5S gene" S_feature 175915..176523 /Source="Nicolas_S_feature" /locus_tag="new_176316_176924" /HighExp="G180, G135, C30, Oxctl, Paraq, Cold, G150, H2O2, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S65" promotor_-35 176491..176495 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 176511..176530 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 176525..176681 /Source="Nicolas_S_feature" /locus_tag="new_176926_177082" /HighExp="LBGstat, G180, G135, dia15, C30, Oxctl, LPhT, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S66" upshifts 176525 /Source="Nicolas_upshifts" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="upshifts" CDS 176682..178118 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388039.1" /db_xref="EnsemblGenomes-Gn:BSU01580" /db_xref="EnsemblGenomes-Tr:CAB11934" /db_xref="GOA:P55189" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR018045" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11562" /db_xref="UniProtKB/Swiss-Prot:P55189" /translation="MNNSFTLKQQWFGNIRKDILAGILVALALIPEAIGFSIIAGVDP MVGLYASFCIAIIISIFGGRPGMISAATGSMAVVMVSLVADHGLQYLFAATILTGIIQ VILGISKIARLMKFIPRSVMIGFVNALAILIFSAQLPQFEGASWSMYAMLAGSLVIIY VLPRFTTAVPSPLVAIIVMTIIAVTFHVDVRTVGDMGNISSSLPHFLIPDVPFTFETL QIIFPYSIALAFVGLLESLLTAQIIDEMTDTDSDKNKESRGQGIANIVTGFFGGMAGC AMIGQSVINTKAGGRGRLSAFVAGAFLMFLIAVLSHVVVKIPMAALVAVMVMVSVGTF DWSSLKGLKKAPLTDSIVMVVTVVTVVVTDDLSKGVFVGVLLSAVFFVAKISKLKIVS HAEDQKLRTYQVKGQIFFASVTDLTNAFIYQEDIERVVIDLTEAHVWDDSGAAALDKI VAKFKEQGIEAELKGLNKASKSLMKQMA*" /label="ybaR CDS" gene 176682..178118 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /label="ybaR gene" downshifts 178107 /Source="Nicolas_upshifts" /id="D56" /incds=0 /nref=144 /ntot=228 /MaxReadThrough="2.81758" /MaxDrop="4.71162" /score="18.4600501" /energy="-12" /TU="NA" /idTUdmin="U111" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 178161..178166 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 178179..178198 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 178197 /Source="Nicolas_upshifts" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="upshifts" CDS 178264..179184 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium dependent transporter" /protein_id="NP_388040.2" /db_xref="EnsemblGenomes-Gn:BSU01590" /db_xref="EnsemblGenomes-Tr:CAB11935" /db_xref="GOA:P55190" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG11563" /db_xref="UniProtKB/Swiss-Prot:P55190" /translation="MPLLTPTSVVLGVLLSQFLNGYEWAVPWIFAFITFAGSLSANFQ SLRHALSHPLPMILALFVLHIFMPLFAWGSGHLIFKGDPLTITGLTLAVVIPTGITSL IWAAMYKGNVGLTLSIILVDTVLSPLIVPLSLSLLAGAQVHMDVWGMMKGLIVMVVIP SFLGMLFNQMSSPERTAFVSSALSPFSKLCLMAVIAINSSAIAPYFKSIDLRFAGIAV TVFFIALTGYAAAWLIGKMMKRRQEEIVSLIFTGGMRNISAGAVLAVTFFPSQVAVPV VIGMLFQQILAALFGYMLNRFELKPMLQKA*" /label="ybaS CDS" gene 178264..179184 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /label="ybaS gene" downshifts 179165 /Source="Nicolas_upshifts" /id="D57" /incds=0 /nref=33 /ntot=224 /MaxReadThrough="1.3063" /MaxDrop="3.58628" /score="13.3102824" /energy="-10.5" /TU="NA" /idTUdmin="U112" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(179194..179946) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 2974033, 17725565, 22210890, 28283524" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 2974033, 17725565, 22210890, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-chelator (enterobactin family) esterase" /protein_id="NP_388041.2" /db_xref="EnsemblGenomes-Gn:BSU01600" /db_xref="EnsemblGenomes-Tr:CAB11936" /db_xref="GOA:P55192" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11565" /db_xref="UniProtKB/Swiss-Prot:P55192" /translation="MKGSLSEHKAGNRRFTLYLPPSYSTDSGGFPAVYVQDGSSLFQN QIELLESAFQQQRLPELVLIGIEPENRLDEYTPWPAASLSDRFTDFGGMGYHYLSDIT NQFIPLIEENWNVTREPQSRGMIGASLGGLISMFAILKYPSMFGKIGSISGSYWYENA AETIHISSLKPGTARVFMSIGSEEGREKQSIQRHMLKKTKQVHQSLKEKGFTEDQLCL SIEKGAVHHHKYFCKQFINALEWLYGKNRSTL*" /label="eesA CDS" gene complement(179194..179946) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /label="eesA gene" downshifts complement(179218) /Source="Nicolas_upshifts" /id="D58" /incds=0 /nref=15 /ntot=115 /MaxReadThrough="0.3819" /MaxDrop="4.57603" /score="25.9728338" /energy="-10.5" /TU="NA" /idTUdmin="U114" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(179943..180953) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2651410, 15849754, 16850406, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-uptake protein" /protein_id="NP_388042.2" /db_xref="EnsemblGenomes-Gn:BSU01610" /db_xref="EnsemblGenomes-Tr:CAB11937" /db_xref="GOA:P40411" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10837" /db_xref="UniProtKB/Swiss-Prot:P40411" /translation="MAKKYALFIALILVVSYFSLTSGSFSVRPAELLSTLFQIDPNPQ YEILLFDLRLPRVVMAAIIGLGLGIAGAVIQAITRNGLADPGILGINAGAGAGIVAFM LLFQGQKEVTSIAAAMGMPLFGLIGGLIAAILIYIFAWHRGNLDSGRIILVGIAINSG FSALSLFLSLKMDPQDYQMAMVWKNGSIWSANWTYITAVLPWMLLFIPILIGKSRLLD TIRFDEDTVRSLGISSNKEKTILLVACVAIISACVSVAGSMAFVGLIAPHISRRLAGV EHRYILPLSGLIGMLLVISADFAGKLFFQPAEVPAGIILAILGVPYFLYLLFKQKKGE NA*" /label="feuC CDS" gene complement(179943..180953) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /label="feuC gene" CDS complement(180946..181950) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2651410, 15849754, 16850406, 17725565; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin permease" /protein_id="NP_388043.1" /db_xref="EnsemblGenomes-Gn:BSU01620" /db_xref="EnsemblGenomes-Tr:CAB11938" /db_xref="GOA:P40410" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10836" /db_xref="UniProtKB/Swiss-Prot:P40410" /translation="MYSKQWTRIILITSPFAIALSLLLSILYGAKHLSTDIVFTSLIH FDPGNTDHQIIWHSRIPRAAGALLIGAALAVSGALMQGITRNYLASPSIMGVSDGSAF IITLCMVLLPQSSSIEMMIYSFIGSALGAVLVFGLAAMMPNGFTPVQLAIIGTVTSML LSSLSAAMSIYFQISQDLSFWYSARLHQMSPDFLKLAAPFFLIGIIMAISLSKKVTAV SLGDDISKSLGQKKKTIKIMAMLSVIILTGSAVALAGKIAFVGLVVPHITRFLVGSDY SRLIPCSCILGGIFLTLCDLASRFINYPFETPIEVVTSIIGVPFFLYLIKRKGGEQNG *" /label="feuB CDS" gene complement(180946..181950) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /label="feuB gene" CDS complement(181969..182922) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8388528, 16889643, 17725565, 21802011, 22303020, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8388528, 16889643, 17725565, 21802011, 22303020, 25355936; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin-binding lipoprotein" /protein_id="NP_388044.1" /db_xref="EnsemblGenomes-Gn:BSU01630" /db_xref="EnsemblGenomes-Tr:CAB11939" /db_xref="GOA:P40409" /db_xref="InterPro:IPR002491" /db_xref="PDB:2PHZ" /db_xref="PDB:2WHY" /db_xref="PDB:2WI8" /db_xref="PDB:2XUZ" /db_xref="PDB:2XV1" /db_xref="SubtiList:BG10835" /db_xref="UniProtKB/Swiss-Prot:P40409" /translation="MKKISLTLLILLLALTAAACGSKNESTASKASGTASEKKKIEYL DKTYEVTVPTDKIAITGSVESMEDAKLLDVHPQGAISFSGKFPDMFKDITDKAEPTGE KMEPNIEKILEMKPDVILASTKFPEKTLQKISTAGTTIPVSHISSNWKENMMLLAQLT GKEKKAKKIIADYEQDLKEIKTKINDKAKDSKALVIRIRQGNIYIYPEQVYFNSTLYG DLGLKAPNEVKAAKAQELSSLEKLSEMNPDHIFVQFSDDENADKPDALKDLEKNPIWK SLKAVKEDHVYVNSVDPLAQGGTAWSKVRFLKAAAEKLTQN*" /label="feuA CDS" gene complement(181969..182922) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /label="feuA gene" promotor_-35 182282..182288 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 182303..182321 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 182312 /Source="Nicolas_upshifts" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(182953..182972) /Source="Nicolas_upshift_promotors" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(182960) /Source="Nicolas_upshifts" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(183013..184602) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16889643, 17725565, 17962296, 22210890" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16889643, 17725565, 17962296, 22210890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AraC/XylS family) of synthesis and uptake of the siderophore bacillibactin" /protein_id="NP_388045.1" /db_xref="EnsemblGenomes-Gn:BSU01640" /db_xref="EnsemblGenomes-Tr:CAB11940" /db_xref="GOA:P40408" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG10834" /db_xref="UniProtKB/Swiss-Prot:P40408" /translation="MQNAVIYQPVQIEYLKKTSDLFSEQQLADSFVLIFHLKGNGYIS IGTNTNPLQKKTLYVCPPNETFGFTPAADGHIDACIIRLLSYIKETGQDIFTPCTESE LAKLKLMNVSHIENLAVRLQELAALWNESSQLSQLKCVIEVQSLIYDLFTASLSDQTD THSAIEKTKHYIETHADTKITLAQLSQMAGISAKHYSESFKKWTGQSVTEFITKTRIT KAKRLMAKSNCKLKEIAHQTGYQDEFYFSRIFKKYTGCSPTSYMKKRRKKIAAYGRGT MGHLIPLHHIPFAAALHPKWTSYYYQHYSTDIPVQLSAYRFNEKWEENLYTLSQAEPD VIVSMDSISPEEQDRLNRIAEVMYLPSEESWRTHFLQTASFLKEESEAEKWLADYDQQ TTAAKKTLQHVQGLRFLFLRLHKQNFYLAHNRSVREVFFGDLGFSSATTADTPSEQAI SLENIANYQADCMMLFLFKEPETIAYYQQLQQTEAWQNLSAVRDNRVYLLSLDPWNEY SACGHERIVQQTVSLLSGDCP*" /label="btr CDS" gene complement(183013..184602) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /label="btr gene" promotor_-10 complement(184643..184662) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(184655) /Source="Nicolas_upshifts" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(184677..184684) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(184764) /Source="Nicolas_upshifts" /id="D59" /incds=0 /nref=19 /ntot=58 /MaxReadThrough="1.28464" /MaxDrop="7.13916" /score="9.64466628" /energy="-10.1" /TU="NA" /idTUdmin="U116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(184793..186037) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388046.1" /db_xref="EnsemblGenomes-Gn:BSU01650" /db_xref="EnsemblGenomes-Tr:CAB11941" /db_xref="InterPro:IPR008302" /db_xref="SubtiList:BG10833" /db_xref="UniProtKB/Swiss-Prot:P40407" /translation="MRKTIFAFLTGLMMFGTITAASASPDSKNQTAKKPKVQTGIDTL LPDYKKQLKGKRIGLITNPAGVNTSLKSSVDILYENPDIKLTALFGPEHGVRGDAQAG DEVGSYIDEKTGVPVYSLYGKTKKPTPEMLKNVDILMFDIQDVGTRFYTYIYTMAYAM EAAKENGIPFMVLDRPNPQGGNHIEGPILEPEYASFVGLYPIPLKHGMTIGELASLFN KEFSIDADLTVVKMKHWKRKMDFDDTRLPFVLPSPNMPTVESTFVYPATGLIEGTNIS EGRGTTKPFELIGAPFIKSTELEETLNSLHLPGVTFRAASFTPTFSKHQGTLCHGVQL YVTDRDKFEAVKTGLSVIKTIHDLYPEDFEFLSTGSFDKLAGNGWIRTKIENGTSVEN IINSYEKTLQQFSKTRKKYLIY*" /label="ybbC CDS" gene complement(184793..186037) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /label="ybbC gene" downshifts complement(184814) /Source="Nicolas_upshifts" /id="D60" /incds=0 /nref=11 /ntot=122 /MaxReadThrough="7.66074" /MaxDrop="4.10379" /score="9.64466628" /energy="-10.1" /TU="U116" /idTUdmin="U116" /TUdmin="-50" /isTUend="FALSE" /label="downshifts" CDS complement(186051..187979) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /EC_number="3.2.1.52" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8063094, 20400549, 20826810, 23177201, 26963691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8063094, 20400549, 20826810, 23177201, 26963691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosaminidase lipoprotein" /protein_id="NP_388047.1" /db_xref="EnsemblGenomes-Gn:BSU01660" /db_xref="EnsemblGenomes-Tr:CAB11942" /db_xref="GOA:P40406" /db_xref="InterPro:IPR001764" /db_xref="InterPro:IPR002772" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR019800" /db_xref="InterPro:IPR036881" /db_xref="InterPro:IPR036962" /db_xref="PDB:3BMX" /db_xref="PDB:3LK6" /db_xref="PDB:3NVD" /db_xref="PDB:4GYJ" /db_xref="PDB:4GYK" /db_xref="SubtiList:BG10832" /db_xref="UniProtKB/Swiss-Prot:P40406" /translation="MRPVFPLILSAVLFLSCFFGARQTEASASKRAIDANQIVNRMSL DEKLGQMLMPDFRNWQKEGESSPQALTKMNDEVASLVKKYQFGGIILFAENVKTTKQT VQLTDDYQKASPKIPLMLSIDQEGGIVTRLGEGTNFPGNMALGAARSRINAYQTGSII GKELSALGINTDFSPVVDINNNPDNPVIGVRSFSSNRELTSRLGLYTMKGLQRQDIAS ALKHFPGHGDTDVDSHYGLPLVSHGQERLREVELYPFQKAIDAGADMVMTAHVQFPAF DDTTYKSKLDGSDILVPATLSKKVMTGLLRQEMGFNGVIVTDALNMKAIADHFGQEEA VVMAVKAGVDIALMPASVTSLKEEQKFARVIQALKEAVKNGDIPEQQINNSVERIISL KIKRGMYPARNSDSTKEKIAKAKKIVGSKQHLKAEKKLAEKAVTVLKNEQHTLPFKPK KGSRILIVAPYEEQTASIEQTIHDLIKRKKIKPVSLSKMNFASQVFKTEHEKQVKEAD YIITGSYVVKNDPVVNDGVIDDTISDSSKWATVFPRAVMKAALQHNKPFVLMSLRNPY DAANFEEAKALIAVYGFKGYANGRYLQPNIPAGVMAIFGQAKPKGTLPVDIPSVTKPG NTLYPLGYGLNIKTGRPL*" /label="nagZ CDS" gene complement(186051..187979) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /label="nagZ gene" CDS complement(188007..189332) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16452451, 20400549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16452451, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidase hydrolyzing N-acetylmuramyl-L-Ala bond of MurNAc peptides" /protein_id="NP_388048.2" /db_xref="EnsemblGenomes-Gn:BSU01670" /db_xref="EnsemblGenomes-Tr:CAB11943" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR022849" /db_xref="SubtiList:BG11566" /db_xref="UniProtKB/Swiss-Prot:O05213" /translation="MKTKTLFIFSAILTLSIFAPNETFAQTAGNLIEPKIINAETAQF STKKLRKVDQMIERDIAAGFPGAVLVVVKDGRIIKKAAYGYSKKYEGSELLRRPAKMK TRTMFDLASNTKMYATNFALQRLVSQGKLDVYEKVSAYLPGFKDQPGDLIKGKDKIRV IDVLQHQSGLPSSFYFYTPEKAGKYYSQERDKTIEYLTKIPLDYQTGTKHVYSDIGYM LLGCIVEKLTGKPLDVYTEQELYKPLRLKHTLYNPLQKGFKPKQFAATERMGNTRDGV IQFPNIRTNTLQGEVHDEKAFYSMDGVSGHAGLFSNADDMAILLQVMLNKGSYRNISL FDQKTADLFTAPSATDPTFALGWRRNGSKSMEWMFGPHASENAYGHTGWTGTVTIIDP AYNLGIALLTNKKHTPVIDPEENPNVFEGDQFPTGSYGSVITAIYEAME*" /label="amiE CDS" gene complement(188007..189332) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /label="amiE gene" CDS complement(189389..190756) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /EC_number="2.7.1.192" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15060041, 15849754, 16850406, 10627040, 20400549, 22960854; Product type t : transporter" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid PTS permease-MurP subunit" /protein_id="NP_388049.3" /db_xref="EnsemblGenomes-Gn:BSU01680" /db_xref="EnsemblGenomes-Tr:CAB11944" /db_xref="GOA:Q797S1" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11567" /db_xref="UniProtKB/Swiss-Prot:Q797S1" /translation="MSKENNYHHLAQKILELCGGKSNISSYTHCMTRLRITPYDESKA DAQALRKLDGVLGVVEAETLQIILGTGVVNHVTAAFSKLVSAEEGADVKEAAAKKKAD INRKNATPFKLFLRKIASIFIPLIPALVASGLITGITKAIIQAGWLSADSQIAIILTV IGSGLFTYLGILVGINASKEFGGTPALGALAGILIINPEIAKISLFGEELLPGRGGLI GVLFAAIFIAYTEQFIRRFIPQSLDIIVTPTVSLLITGIVTYVVFMPLGGFISDAITS GLLSILDIGGIAAGFILGATFLPLVVTGLHQGLTPVHMELINSIGNDPLLPILAMGGA GQVGAAFAVFVKTKKTTLRKAIAGGLPSGLLGIGEPLIFGVTLPLGRPFLTACLGAGI GGAFQAYFQVATIAIGVSGLPLSFLVLPSQIILYIVGLFISYAAGFLLTYAFGYKDEM ASQFD*" /label="murP CDS" gene complement(189389..190756) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /label="murP gene" CDS complement(190782..191633) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20400549; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator MurR-N-acetylmuramic acid" /protein_id="NP_388050.1" /db_xref="EnsemblGenomes-Gn:BSU01690" /db_xref="EnsemblGenomes-Tr:CAB11945" /db_xref="GOA:Q45581" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="PDB:2O3F" /db_xref="SubtiList:BG11569" /db_xref="UniProtKB/Swiss-Prot:Q45581" /translation="MATGGLAIIQSMKHKLPPSERKLADYILAHPHKAIESTVNEISA LANSSDAAVIRLCKSLGLKGFQDLKMRVAGDLAKPTFQGYRDIVPHEPLPSISEKTAG NAIQAIQDTSDLMDYKELERAVSLLLKAHTVHFIGLGASGIVAKDAQQKWLRIHKQAT AFTDTHLVASLIANADKDDIVFAISFSGETQEIVELFAMAKEKGITTISLTQFSQTSV SALADVPLYTAHSNEALIRSAATSSRLAQLFIIDVLFLGMAAEQYETTTGYIDKTRAA IQSMRIK*" /label="murR CDS" gene complement(190782..191633) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /label="murR gene" CDS complement(191650..192564) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /EC_number="4.2.1.126" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15983044, 20400549, 16452451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lactyl ether N-acetylmuramic-6-phosphate acid etherase" /protein_id="NP_388051.1" /db_xref="EnsemblGenomes-Gn:BSU01700" /db_xref="EnsemblGenomes-Tr:CAB11946" /db_xref="GOA:Q45582" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005486" /db_xref="InterPro:IPR005488" /db_xref="SubtiList:BG11570" /db_xref="UniProtKB/Swiss-Prot:Q45582" /translation="MSEPLNLHRLTTESRNSQTVEIHKANTLGILKMINNEDMKVAAA VQEVLPDIKTAVDCAYESFQNGGRLIYTGAGTSGRLGVMDAVECPPTYSVSPDQVIGI MAGGPEAFLQAAEGIEDSEEAGAEDLRNIQLTSNDTVIAIAASGRTPYAAGALRYARK VGAHTIALTCNENSAISKDADHSIEVVVGPEAITGSTRMKAATAHKMILNMISTAVMV KIGKVYENLMVDVNVSNKKLKERAISIIQSLTNASYDTARYTLEQADHHVKTAIVMLK TSTDQKQAQTLLDEANGFIDKAIEHYHP*" /label="murQ CDS" gene complement(191650..192564) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /label="murQ gene" promotor_-10 complement(192595..192613) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(192608) /Source="Nicolas_upshifts" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(192629..192636) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(192674..193156) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_388052.2" /db_xref="EnsemblGenomes-Gn:BSU01710" /db_xref="EnsemblGenomes-Tr:CAB11947" /db_xref="GOA:Q45583" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11571" /db_xref="UniProtKB/Swiss-Prot:Q45583" /translation="MTQDISLSFYKPEHLPELQSFTLTNDDKRFTSLPKEVLSQALGI QDRYPVVILKDDLPVGFFILHASKETLASYSNNPFALLLSSLSLTAVHHGKGYAKKAM LLLPAFVSGYFPWCDEIILAVNHLNIRAKHLYMKSGFLDKGRRRIGPLGEQLILHHFL *" /label="ybbJ CDS" gene complement(192674..193156) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /label="ybbJ gene" CDS complement(193169..193624) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388053.2" /db_xref="EnsemblGenomes-Gn:BSU01720" /db_xref="EnsemblGenomes-Tr:CAB11948" /db_xref="InterPro:IPR007553" /db_xref="SubtiList:BG11572" /db_xref="UniProtKB/Swiss-Prot:Q45584" /translation="MILVSSCLGGIECRYNGSHAASEKIRKLVDEKKAVMACPELLGG FSTPREPAEIIGGTGEDVLNGTAKIVTASGEDVTELYMEGAAKTLAYAKEINASAVIL KENSPSCGSGFIYNGTFSGKKITGSGVTAALLKQAGYRVISENELNDIL*" /label="ybbK CDS" gene complement(193169..193624) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /label="ybbK gene" promotor_-10 complement(193650..193669) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(193671) /Source="Nicolas_upshifts" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(193684..193685) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 193744..193751 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" promotor_-10 193766..193785 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" upshifts 193777 /Source="Nicolas_upshifts" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="upshifts" tRNA 193804..193878 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Glu2 tRNA" gene 193804..193878 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /label="trnSL-Glu2 gene" tRNA 193882..193957 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Val1 tRNA" gene 193882..193957 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /label="trnSL-Val1 gene" tRNA 193962..194034 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Thr1 tRNA" gene 193962..194034 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /label="trnSL-Thr1 gene" tRNA 194057..194141 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Tyr1 tRNA" gene 194057..194141 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /label="trnSL-Tyr1 gene" tRNA 194146..194220 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Gln2 tRNA" gene 194146..194220 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /label="trnSL-Gln2 gene" downshifts 194223 /Source="Nicolas_upshifts" /id="D61" /incds=0 /nref=10 /ntot=91 /MaxReadThrough="4.25215" /MaxDrop="3.84626" /score="25.5087424" /energy="-11.4" /TU="U118" /idTUdmin="U118" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" S_feature 194268..194385 /Source="Nicolas_S_feature" /locus_tag="new_194669_194786" /HighExp="Paraq, BMM, H2O2, Heat, G180, G135, Oxctl, G150, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S67" promotor_-35 194386..194395 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" upshifts 194387 /Source="Nicolas_upshifts" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="upshifts" promotor_-10 194407..194422 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" CDS 194448..195011 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11866510, 15130127, 16629676, 21542858, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11866510, 15130127, 16629676, 21542858, 28319136, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor W" /protein_id="NP_388054.1" /db_xref="EnsemblGenomes-Gn:BSU01730" /db_xref="EnsemblGenomes-Tr:CAB11949" /db_xref="GOA:Q45585" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014294" /db_xref="InterPro:IPR036388" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11573" /db_xref="UniProtKB/Swiss-Prot:Q45585" /translation="MEMMIKKRIKQVKKGDQDAFADIVDIYKDKIYQLCYRMLGNVHE AEDIAQEAFIRAYVNIDSFDINRKFSTWLYRIATNLTIDRIRKKKPDYYLDAEVAGTE GLTMYSQIVADGVLPEDAVVSLELSNTIQQKILKLPDKYRTVIVLKYIDELSLIEIGE ILNIPVGTVKTRIHRGREALRKQLRDL*" /label="sigW CDS" gene 194448..195011 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /label="sigW gene" CDS 195025..195651 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15130127, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 28319136, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(W) factor" /protein_id="NP_388055.1" /db_xref="EnsemblGenomes-Gn:BSU01740" /db_xref="EnsemblGenomes-Tr:CAB11950" /db_xref="GOA:Q45588" /db_xref="InterPro:IPR027383" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11574" /db_xref="UniProtKB/Swiss-Prot:Q45588" /translation="MSCPEQIVQLMHMHLDGDILPKDEHVLNEHLETCEKCRKHFYEM EKSIALVRSTSHVEAPADFTANVMAKLPKEKKRASVKRWFRTHPVIAAAAVFIILMGG GFFNSWHNDHNFSVSKQPNLVVHNHTVTVPEGETVKGDVTVKNGKLIIKGKIDGDVTV VNGEKYMASAGQVTGQIEEINQLFDWTWYKMKSAGKSVLDAFNPNGEE*" /label="rsiW CDS" gene 195025..195651 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /label="rsiW gene" downshifts complement(195443) /Source="Nicolas_upshifts" /id="D62" /incds=1 /nref=2 /ntot=181 /MaxReadThrough="1.52124" /MaxDrop="3.24828" /score="0.305471631" /energy="-6.9" /TU="NA" /idTUdmin="U120" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(195601..195701) /Source="Nicolas_upshift_promotors" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts 195631 /Source="Nicolas_upshifts" /id="D63" /incds=0 /nref=251 /ntot=269 /MaxReadThrough="4.26924" /MaxDrop="8.34597" /score="7.39786279" /energy="-10.8" /TU="U119" /idTUdmin="U119" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" upshifts complement(195641) /Source="Nicolas_upshifts" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 195700..195707 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-35" promotor_-10 195722..195741 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-10" S_feature 195731..195811 /Source="Nicolas_S_feature" /locus_tag="new_196132_196212" /HighExp="dia5, Diami, H2O2, dia15, G135, Cold, G180, Paraq, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA" /TUlongPSig="1, 1" /label="S68" upshifts 195731 /Source="Nicolas_upshifts" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="upshifts" CDS 195812..196633 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /EC_number="2.7.7.85" /function="16.13: Shape" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase" /protein_id="NP_388056.2" /db_xref="EnsemblGenomes-Gn:BSU01750" /db_xref="EnsemblGenomes-Tr:CAB11951" /db_xref="GOA:Q45589" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR034701" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG11577" /db_xref="UniProtKB/Swiss-Prot:Q45589" /translation="MAFEDIPFLQYLGNAVDILLVWYVIYKLIMVIRGTKAVQLLKGI VVIVLVRMASQYLGLSTLQWLMDQAITWGFLAIIIIFQPELRRALEQLGRGRFFSRSG TPVEEAQQKTIEAITKAINYMAKRRIGALLTIERDTGMGDYIETGIPLNAKVSSELLI NIFIPNTPLHDGAVIMKNNEIAAAACYLPLSESPFISKELGTRHRAAVGISEVTDSLT IIVSEETGGVSVAKNGDLHRELTEEALKEMLEAEFKKNTRDTSSNRWYWRGKKNG*" /label="cdaA CDS" gene 195812..196633 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /label="cdaA gene" CDS 196626..198077 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /experiment="publication(s) with functional evidences, PMID:16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of diadenylate cyclase activity" /protein_id="NP_388057.2" /db_xref="EnsemblGenomes-Gn:BSU01760" /db_xref="EnsemblGenomes-Tr:CAB11952" /db_xref="GOA:O34659" /db_xref="InterPro:IPR012505" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12703" /db_xref="UniProtKB/Swiss-Prot:O34659" /translation="MDKFLNNRWAVKIIALLFALLLYVAVNSNQAPTPKKPGESFFPT STTDEATLTDIPVKAYYDDENYVVTGVPQTVNVTIKGSTSAVKKARQTKNFEIYADME HLKTGTHKVELKAKNVSDGLTISINPSVTTVTIQERTTKSFPVEVEYYNKSKMKKGYS PEQPIVSPKNVQITGSKNVIDNISLVKASVNLENADETIEKEAKVTVYDKDGNALPVD VEPSVIKITVPVTSPSKKVPFKIERTGSLPDGVSIANIESSPSEVTVYGSQDVLDSLE FIDGVSLDLSKINKDSDIEADIPLPDGVKKISPSKVTLHIEVDSEADQKFENVPIKTV GLSSSQNIEFLDPESQAIDVTAKGSPTNINKLKKSDIELYVNVSDLEDGEHSVKLEVN GPQNVTWSLGRKNAKIKLTSKKSNTSTNDNSSNTSGNQDTDKQTNDQKNNQQEDTKNT DKNNNDQNQDGNKDQNQDQDEDESTANSQSSSE*" /label="cdaR CDS" gene 196626..198077 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /label="cdaR gene" CDS 198096..199442 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /EC_number="5.4.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10671448, 10913078, 12089032, 21154411, 26240071, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671448, 10913078, 12089032, 21154411, 26240071, 27074767; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoglucosamine mutase" /protein_id="NP_388058.1" /db_xref="EnsemblGenomes-Gn:BSU01770" /db_xref="EnsemblGenomes-Tr:CAB11953" /db_xref="GOA:O34824" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR006352" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG12704" /db_xref="UniProtKB/Swiss-Prot:O34824" /translation="MGKYFGTDGVRGVANSELTPELAFKVGRFGGYVLTKDKQRPKVL IGRDTRISGHMLEGALVAGLLSIGAEVMRLGVISTPGVSYLTKAMDAEAGVMISASHN PVQDNGIKFFGGDGFKLSDEQEAEIERLMDEPEDKLPRPVGADLGLVNDYFEGGQKYL QFLKQTADEDFTGIHVALDCANGATSSLATHLFADLDADVSTMGTSPNGLNINDGVGS THPEALSAFVKEKNADLGLAFDGDGDRLIAVDEKGNIVDGDQIMYICSKHLKSEGRLK DDTVVSTVMSNLGFYKALEKEGIKSVQTAVGDRYVVEAMKKDGYNVGGEQSGHLIFLD YNTTGDGLLSAIMLMNTLKATGKPLSELAAEMQKFPQLLVNVRVTDKYKVEENEKVKA VISEVEKEMNGDGRILVRPSGTEPLVRVMAEAKTKELCDEYVNRIVEVVRSEMGLE*" /label="glmM CDS" gene 198096..199442 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /label="glmM gene" downshifts 199437 /Source="Nicolas_upshifts" /id="D64" /incds=0 /nref=126 /ntot=216 /MaxReadThrough="5.32721" /MaxDrop="5.02497" /score="13.5044076" /energy="-17.5" /TU="U121" /idTUdmin="U121" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_-35 199461..199469 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 199477 /Source="Nicolas_upshifts" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 199483..199502 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 199529..199534 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 199550..199569 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 199556 /Source="Nicolas_upshifts" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" misc_feature 199600..199616 /Source="Nicolas_upshift_promotors" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 199613 /Source="Nicolas_upshifts" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 199616..199786 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /product="riboswitch and ribozyme (GlmS-glucosamine-6-P)" /experiment="publication(s) with functional evidences, PMID:16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261; Product type n: RNA" /label="glmSA RNA" gene 199616..199786 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /label="glmSA gene" S_feature 199787..199875 /Source="Nicolas_S_feature" /locus_tag="new_200188_200276" /HighExp="M40t90, M0t90, M9-stat, Lbstat, T2.30H, T2.0H, T3.0H, T1.30H, T1.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.498, 0.999, 0.754" /TUlongSig="SigA, SigWXY, SigA" /TUlongPSig="1, 1, 1" /label="S69" CDS 199876..201678 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /EC_number="2.6.1.16" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15029187, 17114942, 17283212, 17322533, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine-D-fructose-6-phosphate amidotransferase" /protein_id="NP_388059.1" /db_xref="EnsemblGenomes-Gn:BSU01780" /db_xref="EnsemblGenomes-Tr:CAB11954" /db_xref="GOA:P0CI73" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005855" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR035466" /db_xref="InterPro:IPR035490" /db_xref="SubtiList:BG10948" /db_xref="UniProtKB/Swiss-Prot:P0CI73" /translation="MCGIVGYIGQLDAKEILLKGLEKLEYRGYDSAGIAVANEQGIHV FKEKGRIADLREVVDANVEAKAGIGHTRWATHGEPSYLNAHPHQSALGRFTLVHNGVI ENYVQLKQEYLQDVELKSDTDTEVVVQVIEQFVNGGLETEEAFRKTLTLLKGSYAIAL FDNDNRETIFVAKNKSPLLVGLGDTFNVVASDAMAMLQVTNEYVELMDKEMVIVTDDQ VVIKNLDGDVITRASYIAELDASDIEKGTYPHYMLKETDEQPVVMRKIIQTYQDENGK LSVPGDIAAAVAEADRIYIIGCGTSYHAGLVGKQYIEMWANVPVEVHVASEFSYNMPL LSKKPLFIFLSQSGETADSRAVLVQVKALGHKALTITNVPGSTLSREADYTLLLHAGP EIAVASTKAYTAQIAVLAVLASVAADKNGINIGFDLVKELGIAANAMEALCDQKDEME MIAREYLTVSRNAFFIGRGLDYFVCVEGALKLKEISYIQAEGFAGGELKHGTIALIEQ GTPVFALATQEHVNLSIRGNVKEVAARGANTCIISLKGLDDADDRFVLPEVNPALAPL VSVVPLQLIAYYAALHRGCDVDKPRNLAKSVTVE*" /label="glmS CDS" gene 199876..201678 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /label="glmS gene" S_feature complement(201401..>201681) /Source="Nicolas_S_feature" /locus_tag="new_201802_202546_c" /HighExp="S8, S7, S6, S5, S4, BC, S3, Sw, C30, LoTm" /AntisenseName="glmS" /AntisenseCor="4.5056549205256403E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S70" downshifts 201664 /Source="Nicolas_upshifts" /id="D65" /incds=0 /nref=260 /ntot=277 /MaxReadThrough="3.18134" /MaxDrop="7.61794" /score="13.5044076" /energy="-17.5" /TU="NA" /idTUdmin="U122" /TUdmin=2 /isTUend="TRUE" /label="downshifts" SCAR join(201681,201727) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta4" N_region 201682..201726 /note="insertion of 45 bases of unknown origin" /modified_by="User" /label="Delta4" S_feature <201727..201845 /Source="Nicolas_S_feature" /locus_tag="new_220105_220278" /HighExp="LoTm, T5.0H, T4.0H, T3.30H, Pyr, T-2.40H, T3.0H, T-5.40H, S2, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.984" /TUlongSig="NA" /TUlongPSig="NA" /label="S79" CDS 201846..202823 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase/transferase" /protein_id="NP_388081.2" /db_xref="EnsemblGenomes-Gn:BSU01990" /db_xref="EnsemblGenomes-Tr:CAB11993" /db_xref="GOA:O31431" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12722" /db_xref="UniProtKB/Swiss-Prot:O31431" /translation="MKTLWKVLKIVFVSLAALVLLVSVSVFIYHHFQLNKEAALLKGK GTVVDVDGKKMNVYQEGSGKDTFVFMSGSGIAAPAYEMKGLYSKFSKENKIAVVDRAG YGYSEVSHDDRDIDTVLEQTRKALMKSGNKPPYILMPHSISGIEAMYWAQKYPKEIKA IIAMDIGLPQQYVTYKLSGVDRLKVRGFHLLTSIGFHRFIPSAVYNPEVIRQSFLTDE EKEIYKAINFKQFFNADMEHELLQSYQNGSKSVNLPAPKETPVLILDAVSDQNRHSKY AIQNRKDYEAFAAQFNTADIKELRGTHSIYLYQPDQIYKLSMEFMRKVR*" /label="ybdG CDS" gene 201846..202823 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /label="ybdG gene" CDS 202825..203496 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component system response regulator [YbdK]" /protein_id="NP_388082.1" /db_xref="EnsemblGenomes-Gn:BSU02000" /db_xref="EnsemblGenomes-Tr:CAB11994" /db_xref="GOA:O31432" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12723" /db_xref="UniProtKB/Swiss-Prot:O31432" /translation="MKGYRILIVEDDVMIGDLLQKILQREGYRVIWKTDGADVLSVIQ KVDLVIMDVMLPGEDGYQMSAKIKKLGLGIPVIFLSARNDMDSKLQGLQIGEDYMVKP FDPRELLLRMRNMLEHHYGTFTQIKHLYIDAVTKKVFNESLHDEVLFTAIERKIFFYL YENRDSILTKEHFFEYLWQLEDRNPNIVNVHIKKIRAKINDQAGEMIENIYGEGYRLN TVVKK*" /label="ybdJ CDS" gene 202825..203496 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /label="ybdJ gene" promotor_-35 203390..203396 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 203410..203429 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 203428 /Source="Nicolas_upshifts" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="upshifts" CDS 203517..204479 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component system sensor histidine kinase [YbdJ]" /protein_id="NP_388083.1" /db_xref="EnsemblGenomes-Gn:BSU02010" /db_xref="EnsemblGenomes-Tr:CAB11995" /db_xref="GOA:O31433" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12724" /db_xref="UniProtKB/Swiss-Prot:O31433" /translation="MLLFTAVISVPMLLLAVSVLMSVIYDSMFKPMNHGMPFHRSFAY PAMIVVFLISLLLLAFLFSKSIHSLLHKINLLNQTIRHLASDQRVPDKIEVKRADEIG ELIKSVNLLIERTTYRELELRQQEEIKKELLQKLRHDINTPLTALRLQLFYLEDQCHG QAVFESLYQQIEYISELTNEFNLYSAETLESSYIVNEEVRLNELLETAVKKWDYLYSM SGIELHYKPADQDVIWMSNTLWMERLFDNIFQNTLRHSKAKKMEVTIEHGDVFIRDDG IGFDRNESSEGLGLKIIEDTCRLLAITYELHTNDNGTGFLFSKE*" /label="ybdK CDS" gene 203517..204479 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /label="ybdK gene" promotor_-35 204491..204493 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 204509..204528 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 204512 /Source="Nicolas_upshifts" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="upshifts" CDS 204538..204801 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097672.1" /db_xref="EnsemblGenomes-Gn:BSU02019" /db_xref="EnsemblGenomes-Tr:CAX52542" /db_xref="UniProtKB/Swiss-Prot:C0H3T1" /translation="MNIICLKKSSKRLSTSQAVLVTDIADTGITAAAGADIIAATAAV RAKEDTTTVMAAVIVTNAGATAAVNPKKVLVPLLGQGFFYVTD*" /label="ybzI CDS" gene 204538..204801 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /label="ybzI gene" downshifts 204742 /Source="Nicolas_upshifts" /id="D73" /incds=0 /nref=120 /ntot=235 /MaxReadThrough="2.82444" /MaxDrop="4.652" /score="22.3698707" /energy="-12.1" /TU="U135" /idTUdmin="U136" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(204786..205556) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /EC_number="2.7.11.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21304896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative protein kinase" /protein_id="NP_388085.1" /db_xref="EnsemblGenomes-Gn:BSU02030" /db_xref="EnsemblGenomes-Tr:CAB11997" /db_xref="GOA:O31435" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG12726" /db_xref="UniProtKB/Swiss-Prot:O31435" /translation="MALKLLKKLLFDRPLKNGVILNHQYKIEECLGMGGYGLVYLCTD ILAQTPYVLKQLRPTKAKKEKEKVRFQQEIKLLKNIHHPQIPGFIDEFIIDGQAYYVM QFIEGENIEELLFFRKQPFTELMALQLISQLLEIIEYLHDRLIFHSDIRTPNIIINDG RLCLIDFGLAKQLTPEEMEEIKVRKQDDFFDLGETLLFLLYSQYKGKKKKNGTWLEEL TLTKEVTLLLKRLLGIEEEYQHTASIREDLNRAIQSVT*" /label="ybdM CDS" gene complement(204786..205556) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /label="ybdM gene" CDS complement(205642..206499) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16794953; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388086.1" /db_xref="EnsemblGenomes-Gn:BSU02040" /db_xref="EnsemblGenomes-Tr:CAB11998" /db_xref="SubtiList:BG12727" /db_xref="UniProtKB/Swiss-Prot:O31436" /translation="MVKKWLIQFAVMLSVLSTFTYSASAVGVTAITGNNSFDTAMPIG YWKYKNIDTTILEAGQDEAYFTFTANKGEKVYMRSTYQSAYTGMKIEIYDKNRIPVSQ GTEVINPNTFSSFIYANADAQNTTDTFYVKVSRGTYTGNMYFTLSIEDRIKSGSGTFQ FSGVAENKGNTSLSPSGSDSSVIKVDLTNQSGIPRDAIVTRVQTTATQTPSQGNTRHL IMTSENNEWSRALVNSSTSGSYDISLSDQLSVAKVWSFKYNTLATARSTMSNVKAKID YEYDVTKQF*" /label="ybdN CDS" gene complement(205642..206499) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /label="ybdN gene" downshifts complement(205664) /Source="Nicolas_upshifts" /id="D74" /incds=0 /nref=95 /ntot=184 /MaxReadThrough="1.56932" /MaxDrop="4.95806" /score="36.4950689" /energy="-11.9" /TU="NA" /idTUdmin="U137" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(205713..205732) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(205746..205755) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(205748) /Source="Nicolas_upshifts" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(206512..206531) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(206537) /Source="Nicolas_upshifts" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(206546..206553) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 206567..206574 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-35" promotor_-10 206588..206606 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-10" upshifts 206590 /Source="Nicolas_upshifts" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="upshifts" CDS 206631..207815 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388087.1" /db_xref="EnsemblGenomes-Gn:BSU02050" /db_xref="EnsemblGenomes-Tr:CAB11999" /db_xref="InterPro:IPR032617" /db_xref="SubtiList:BG12728" /db_xref="UniProtKB/Swiss-Prot:O31437" /translation="MRLNRQFIRTQLIAQNILSKNAPAKRENATENPAAVLEKAYSRL KSQSSTGGINQFNYSKTSVSGNSGTFSKVYQSANDRTVTDTGEETVIQSQNPYESESD IRIKILDEKYSRMNAINKTKSDPLGYIKDKYQNSKSPYFRSDLSAAERQAAYDNETEW LFKGKAQNYNLQDAVFRNVTFHGEVEAENEKVYQRGQVNQQLQVLLNRNHIHIPEGTE LTFTITPIDYQVRVSGTDDQDLIKQIEQVLQSGDNSKELFLHIMKSQSSDSAQFSEEA YKKYQAAREMYEVTGYHLKDLEVIDGRYVTPEGRDLMDVYKEELEKDPVQKQTASYAI SYYRSELSKIAEAGYNAIPDFILSIDYSNGSLRDVGQSKSYGTGDTGWLEALKRQTGV NY*" /label="ybdO CDS" gene 206631..207815 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /label="ybdO gene" downshifts 207801 /Source="Nicolas_upshifts" /id="D75" /incds=0 /nref=107 /ntot=207 /MaxReadThrough="2.98334" /MaxDrop="4.9582" /score="-3.87053033" /energy="-8.3" /TU="U139" /idTUdmin="U139" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" promotor_-35 207969..207975 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 207989..208008 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 208003..208132 /Source="Nicolas_S_feature" /locus_tag="new_226436_226565" /HighExp="Glu, LoTm, M9-stat, G135, GM-0.2, T-0.40H, Fru, UNK1, MG 120, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD" /TUlongPSig=1 /label="S80" upshifts 208003 /Source="Nicolas_upshifts" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="upshifts" CDS 208133..209521 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388088.1" /db_xref="EnsemblGenomes-Gn:BSU02060" /db_xref="EnsemblGenomes-Tr:CAB12000" /db_xref="GOA:P54425" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11505" /db_xref="UniProtKB/Swiss-Prot:P54425" /translation="MANKELKRGLGARHIQMIALGGTIGVGLFMGSASTISWTGPSVL LAYAICGIFIFFIMRAMGEMLYVEPSTGSFATFGHQYIHPMAGYITAWSNWFQWIIVG MSEIIAVGSYTKYWFPDLPAWIPGIVAMVILGAANLISVKSFGEFEFWFAMIKIVTII LMIIAGIGIIFFGFGNGGDAIGLSNLWSHGGFFAGGFSGFFFALSLVIAAYQGVELIG ITAGEAKDPQNTLRNAIQSIIWRILIFYIGAIFVIVTVYPWDELNSLGSPFVSTFSKI GITAAAGIINFVVITAAMSGCNSGIFSAGRMLYTLGVNGQAPKFFKKISRNGVPLYGT IAVLIGLAVGVVLNYIAPPKIFVYVYSASVLPGMIPWFIILISHIGFRKAKGAALDKH PFKMPFAPFTNYLTIAFLLMVLVGMWFNDDTRISLIVGVIFLALVVISYYVFGIGKRT QANLTKSEQAAE*" /label="ybxG CDS" gene 208133..209521 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /label="ybxG gene" downshifts 209529 /Source="Nicolas_upshifts" /id="D76" /incds=0 /nref=121 /ntot=219 /MaxReadThrough="2.32902" /MaxDrop="5.72049" /score="28.6554212" /energy="-8.5" /TU="NA" /idTUdmin="U140" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" promotor_-35 209567..209573 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 209587..209598 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 209588 /Source="Nicolas_upshifts" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="upshifts" CDS 209633..209881 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9016963" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9016963; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific SASP protein" /protein_id="NP_388089.1" /db_xref="EnsemblGenomes-Gn:BSU02070" /db_xref="EnsemblGenomes-Tr:CAB12001" /db_xref="GOA:P54379" /db_xref="InterPro:IPR020255" /db_xref="SubtiList:BG11504" /db_xref="UniProtKB/Swiss-Prot:P54379" /translation="MDVTLGYLRESLSNHLENEVCQRICKKMLAKRYANEEEFVKDLD DNEMSFLNHVLEKEIKYAQNEQDQKRAKELNEVYELLL*" /label="csgA CDS" gene 209633..209881 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /label="csgA gene" CDS 209898..210089 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388090.1" /db_xref="EnsemblGenomes-Gn:BSU02080" /db_xref="EnsemblGenomes-Tr:CAB12002" /db_xref="InterPro:IPR035314" /db_xref="SubtiList:BG11506" /db_xref="UniProtKB/Swiss-Prot:P54426" /translation="MGAIERSGYTFQPEFSVVRQNGAIHVYHQGEFVEEIEFEFNGEY PDHDLIEELVNHYCFEHEI*" /label="ybxH CDS" gene 209898..210089 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /label="ybxH gene" downshifts 210071 /Source="Nicolas_upshifts" /id="D77" /incds=0 /nref=17 /ntot=40 /MaxReadThrough="0.194030000000001" /MaxDrop="4.779" /score="29.4617878" /energy="-15.6" /TU="NA" /idTUdmin="U141" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(210116..210919) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /EC_number="3.5.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14742199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14742199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported beta-lactamase" /protein_id="NP_388091.1" /db_xref="EnsemblGenomes-Gn:BSU02090" /db_xref="EnsemblGenomes-Tr:CAB12003" /db_xref="GOA:P54427" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR002137" /db_xref="InterPro:IPR012338" /db_xref="PDB:5E2F" /db_xref="SubtiList:BG11507" /db_xref="UniProtKB/Swiss-Prot:P54427" /translation="MKKWIYVVLVLSIAGIGGFSVHAASSAHEKHLNVSKMNVDDEFK DTDGTFILHDLQKDQTFVYNRKRANQRQTPQSTFKVVNALIGLQVKAVRDEYDVKRWD GVKREFESWNRDHTLGSAMRESAIWYYQALARDIGEERMKTWLHTLSYGNEDISGGID QFWLQSSLTISPLEQETFLEKLAKEELPFDKPVMKIVKRMMIQEEGDHYTLYGKTGTR LTDMGLGWFVGFIKTEHGSYVFVTNVDDSGTKAKNITVDILKKYGLITS*" /label="ybxI CDS" gene complement(210116..210919) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /label="ybxI gene" promotor_-10 complement(210941..210959) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(210949) /Source="Nicolas_upshifts" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(210970..210978) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 211033..211039 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 211054..211072 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 211060 /Source="Nicolas_upshifts" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="upshifts" CDS 211092..212345 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /EC_number="1.11.2.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10529095, 12519760, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10529095, 12519760, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid beta-hydroxylating cytochrome P450" /protein_id="NP_388092.1" /db_xref="EnsemblGenomes-Gn:BSU02100" /db_xref="EnsemblGenomes-Tr:CAB12004" /db_xref="GOA:O31440" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002401" /db_xref="InterPro:IPR036396" /db_xref="PDB:1IZO" /db_xref="PDB:2ZQJ" /db_xref="PDB:2ZQX" /db_xref="SubtiList:BG12729" /db_xref="UniProtKB/Swiss-Prot:O31440" /translation="MNEQIPHDKSLDNSLTLLKEGYLFIKNRTERYNSDLFQARLLGK NFICMTGAEAAKVFYDTDRFQRQNALPKRVQKSLFGVNAIQGMDGSAHIHRKMLFLSL MTPPHQKRLAELMTEEWKAAVTRWEKADEVVLFEEAKEILCRVACYWAGVPLKETEVK ERADDFIDMVDAFGAVGPRHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMA FHTQEDGSQLDSRMAAIELINVLRPIVAISYFLVFSALALHEHPKYKEWLRSGNSRER EMFVQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEF RPERFAEREENLFDMIPQGGGHAEKGHRCPGEGITIEVMKASLDFLVHQIEYDVPEQS LHYSLARMPSLPESGFVMSGIRRKS*" /label="cypC CDS" gene 211092..212345 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /label="cypC gene" misc_feature 211404..211411 /Source="Nicolas_upshift_promotors" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 211414 /Source="Nicolas_upshifts" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 212338 /Source="Nicolas_upshifts" /id="D78" /incds=0 /nref=5 /ntot=36 /MaxReadThrough="2.65245" /MaxDrop="6.12325" /score="-7.42298703" /energy="-14.7" /TU="NA" /idTUdmin="U143" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(212386..212646) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388093.1" /db_xref="EnsemblGenomes-Gn:BSU02110" /db_xref="EnsemblGenomes-Tr:CAB12005" /db_xref="SubtiList:BG12754" /db_xref="UniProtKB/Swiss-Prot:O31441" /translation="MKQKLLLSGLAVSTVGITSYLLKDPSNRQKAREFIHSMKMKITK QPDMETFPVDKAGHPDPQDIEDNKMVSEGSMYPVQYYDEKKK*" /label="ybyB CDS" gene complement(212386..212646) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /label="ybyB gene" downshifts complement(212405) /Source="Nicolas_upshifts" /id="D79" /incds=0 /nref=155 /ntot=247 /MaxReadThrough="3.63752" /MaxDrop="7.83539" /score="8.86703843" /energy="-12.4" /TU="U145" /idTUdmin="U145" /TUdmin="-387" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(212676..212694) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(212685) /Source="Nicolas_upshifts" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(212708..212714) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 212838..212845 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 212855 /Source="Nicolas_upshifts" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 212861..212880 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 212915..214534 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/amino acid transporter" /protein_id="NP_388094.2" /db_xref="EnsemblGenomes-Gn:BSU02120" /db_xref="EnsemblGenomes-Tr:CAB12006" /db_xref="GOA:Q45577" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12730" /db_xref="UniProtKB/Swiss-Prot:Q45577" /translation="MNQLHRRMGTFSLMMVGLGSMIGSGWLFGAWRAAQIAGPAAIIS WVIGMVVILFIALSYSELGSMFPEAGGMVKYTQYSHGSFIGFIAGWANWIAIVSVIPV EAVASVQYMSSWPWEWAKWTSGLVKNGTLTGEGLAFASVLLLIYFLLNYWTVNLFSKA NSLITIFKIIIPGLTIGALLFVGFHGENFTGGQSIAPNGWASVLTAVATSGIVFAFNG FQSPINMAGEAKNPGKSIPIAVVGSLFVATVIYVLLQIAFIGAVNPSDIAHGWSHLNF NSPFADLAIALNINWLVIVLYADAFVSPSGTGITYTATTSRMIYGMEKNKYMPSIFGK LHPIYGVPRQAMFFNLIVSFIFLFLFRGWGVLAEIISVATLISYITGPITVMTLRRTG KDLYRPLRLKGLNVIAPLGFIFASLVLYWARWPLTGQVLFIILIGLPIYFYYQAKAKW KGFGRNFKAGVWMVFYLLAMMVISYLGSDKFGGLNVIHYGWDMVLIAMVSLVFYVWAL KSGYQTEYLKDAKEINSQLLNGQSEAAAGKE*" /label="ybeC CDS" gene 212915..214534 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /label="ybeC gene" downshifts 214517 /Source="Nicolas_upshifts" /id="D80" /incds=0 /nref=183 /ntot=273 /MaxReadThrough="0.8051" /MaxDrop="6.79949" /score="24.7668372" /energy="-12.2" /TU="NA" /idTUdmin="U146" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(214581..215462) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10913081, 21966272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 21966272; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted glycerophosphoryl diester phosphodiesterase" /protein_id="NP_388095.1" /db_xref="EnsemblGenomes-Gn:BSU02130" /db_xref="EnsemblGenomes-Tr:CAB12007" /db_xref="GOA:P37965" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="PDB:5T91" /db_xref="PDB:5T9B" /db_xref="PDB:5T9C" /db_xref="SubtiList:BG10646" /db_xref="UniProtKB/Swiss-Prot:P37965" /translation="MRKNRILALFVLSLGLLSFMVTPVSAASKGNLLSPDRILTVAHR GASGYVPEHTILSYETAQKMKADFIELDLQMTKDGKLIVMHDEKLDRTTNGMGWVKDH TLADIKKLDAGSWFNEAYPEKAKPQYVGLKVPTLEEVLDRFGKHANYYIETKSPDTYP GMEEKLIASLQKHKLLGKHSKPGQVIIQSFSKESLVKVHQLQPNLPTVQLLEAKQMAS MTDAALEEIKTYAVGAGPDYKALNQENVRMIRSHGLLLHPYTVNNEADMHRLLDWGVT GVFTNYPDLFHKVKKGY*" /label="glpQA CDS" gene complement(214581..215462) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /label="glpQA gene" downshifts complement(214592) /Source="Nicolas_upshifts" /id="D81" /incds=0 /nref=61 /ntot=107 /MaxReadThrough="2.31368" /MaxDrop="7.76277" /score="9.56390732" /energy="-11.4" /TU="NA" /idTUdmin="U147" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(215505) /Source="Nicolas_upshifts" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(215514..215530) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(215539..215545) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(215561..216895) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8012593, 11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012593, 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate permease" /protein_id="NP_388096.1" /db_xref="EnsemblGenomes-Gn:BSU02140" /db_xref="EnsemblGenomes-Tr:CAB12008" /db_xref="GOA:P37948" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR005267" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR021159" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10645" /db_xref="UniProtKB/Swiss-Prot:P37948" /translation="MLNIFKPAPHIERLDDSKMDAAYKRLRLQVFIGIFIGYAGYYLL RKNFAFAIPYLQEQGFSKTELGLVLAAVSIAYGFSKFIMGMVSDRCNPRYFLATGLFL SAIVNILFVSMPWVTSSVTIMFIFMFINGWFQGMGWPPCGRTMAHWFSISERGTKMSI WNVAHNIGGGILAPLVTLGIAMFVTWKSVFFFPAIIAIIISFLIVLLVRDTPQSCGLP PIEEYRNDYPKHAFKNQEKELTTKEILFQYVLNNKFLWYIAFANVFVYFVRYGVVDWA PTYLTEAKGFSPEDSRWSYFLYEYAGIPGTILCGWISDRFFKSRRAPAGVLFMAGVFI AVLVYWLNPAGNPLVDNIALISIGFLIYGPVMLIGLQAIDLAPKKAAGTAAGLTGFFG YIGGSAFANAIMGFVVDRFNWNGGFIMLISSCILAIVFLALTWNTGKRAEHV*" /label="glpT CDS" gene complement(215561..216895) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /label="glpT gene" promotor_-35 216543..216552 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 216565..217191 /Source="Nicolas_S_feature" /locus_tag="new_234998_235624" /HighExp="S6, S8, S7, S5, BT, B36, G/S, C30, Pyr, B60" /AntisenseName="glpT" /AntisenseCor="-5.0958691169636701E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S81" promotor_-10 216565..216584 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 216565 /Source="Nicolas_upshifts" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(216896..216968) /Source="Nicolas_S_feature" /locus_tag="new_235329_235401_c" /HighExp="G150, Oxctl, Paraq, S0, Diami, H2O2, Lbexp, dia5, dia0, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.042, 0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S82" promotor_no_box complement(216928..217028) /Source="Nicolas_upshift_promotors" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(216968) /Source="Nicolas_upshifts" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(216970..217056) /Source="Nicolas_S_feature" /locus_tag="new_235403_235489_c" /HighExp="G150, Oxctl, S0, Diami, Lbexp, dia5, Paraq, dia0, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S83" promotor_-10 complement(217046..217065) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(217060) /Source="Nicolas_upshifts" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(217078..217085) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 217192..217440 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388097.1" /db_xref="EnsemblGenomes-Gn:BSU02150" /db_xref="EnsemblGenomes-Tr:CAB12009" /db_xref="GOA:O31442" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG12731" /db_xref="UniProtKB/Swiss-Prot:O31442" /translation="MDELDIAFFILPLGIMLLSIVGTCICKNPYLMPMLSLVISLVLT FTIFNQSFLGWAVVYSLVSLALSYITLIVVRKRKESGN*" /label="ybeF CDS" gene 217192..217440 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /label="ybeF gene" promotor_-35 217464..217471 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 217471 /Source="Nicolas_upshifts" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 217487..217506 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 217532..218449 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator with acetyltransferase domain" /protein_id="NP_388098.1" /db_xref="EnsemblGenomes-Gn:BSU02160" /db_xref="EnsemblGenomes-Tr:CAB12010" /db_xref="GOA:O31443" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12732" /db_xref="UniProtKB/Swiss-Prot:O31443" /translation="MKTRESSVGLKFRKFNRFYTNVLGFLNEHIYDSPFSLTETRILF EIYNTPNCTAKALQDKLGLDRGYVSRIVKQFEKEDLIYKQRSKDDARHHYIFVTETGK TIYKKLEEKANEQVELMLKVINQKEQHKLAEAMAEIEAILSQSLSARASEISIRDYFL SEDLQLLIEKQRQFYAEAHGWDDTFLAYLQETFDADIEKIWIAESGGKFAGSVGLVKH DEKTVQLRWFLVDADFRGRGLGTQLLEHLVAYCQDMKFDRIFLWTVSTMAEARPLYKK FGFRISEVKQEAPLWGQQLTEERWDLELS*" /label="ybfA CDS" gene 217532..218449 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /label="ybfA gene" CDS 218446..219696 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carboxylate transporter" /protein_id="NP_388099.1" /db_xref="EnsemblGenomes-Gn:BSU02170" /db_xref="EnsemblGenomes-Tr:CAB12011" /db_xref="GOA:O31444" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12733" /db_xref="UniProtKB/Swiss-Prot:O31444" /translation="MKRLHYAWIIVSVTFLILLAVQGVRLSFGAFVEPWERQFSIDRS TISLISTVSFIVYGISQPVIGRLVDKWGARAVLAWSALLTGVSIFLTYLVTSPWQLFL LYGLGVSLGVGGASNVAASVLVVNWFSKKRGLAFGIMEAGFGAGQMLLVPGSLMLIHW FSWKLTVVVLGLLLIVIVFPAALLMLRNNPSEKNTEPIGGLAASEKETAPKTTALSVA GMFRMRQFWFLIFPFLICGFTTVGLMDTHLIPFSHDHGFSTTVTSAAVSLLAGFNIAG ILLSGIVADRWSSRKILCILYAVRALSIVILIYSHEPYLLLAFAILFGLVDFATVAPT QMLATQYFQNYSIGLMIGWLSLAHQIGSALGAYVPGVIYTVTGEYTLAFYLSIGMLVL ASVMNVMLREPAAVTRDSAAVVDK*" /label="ybfB CDS" gene 218446..219696 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /label="ybfB gene" downshifts 219686 /Source="Nicolas_upshifts" /id="D82" /incds=0 /nref=57 /ntot=187 /MaxReadThrough="1.17226" /MaxDrop="5.55429" /score="12.1347284" /energy="-9.5" /TU="NA" /idTUdmin="U151" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(219731..220015) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminal end)" /db_xref="EnsemblGenomes-Gn:BSU02180" /db_xref="EnsemblGenomes-Tr:CAB12012" /db_xref="GOA:O31445" /db_xref="PSEUDO:CAB12012.2" /db_xref="SubtiList:BG12734" /db_xref="UniProtKB/Swiss-Prot:O31445" /translation="MNHCLHSNTLAKIVCTVTLITLYFYFFSTRFNELIELAVQMFFA LIGLFWVFIVSPFSRKVQISERFKQKSENARIVGMIDFVLEQKYKKSISE*" /label="ybfEc CDS" gene complement(219731..220015) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /pseudo /label="ybfEc gene" downshifts complement(219784) /Source="Nicolas_upshifts" /id="D83" /incds=0 /nref=4 /ntot=189 /MaxReadThrough="2.49989" /MaxDrop="3.7302" /score="13.7144473" /energy="-12.6" /TU="U153" /idTUdmin="U153" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(219921..220043) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function YbfE (N-terminal fragment)" /db_xref="PSEUDO:SOX90538.1" /translation="MLNQLKVFFSEPLLTFKHTCQNRMYCDINNVILLFFQHSF*" /label="ybfEn CDS" gene complement(219921..220043) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /pseudo /label="ybfEn gene" S_feature complement(220016..220136) /Source="Nicolas_S_feature" /locus_tag="new_238449_238569_c" /HighExp="Lbexp, dia0, LBGexp, G150, Mt0, H2O2, dia5, M0t45, G135, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-" /TUshortPSig="0.899, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S84" promotor_-10 complement(220121..220139) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(220136) /Source="Nicolas_upshifts" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(220138..220210) /Source="Nicolas_S_feature" /locus_tag="new_238571_238643_c" /HighExp="Lbexp, dia0, LBGexp, HPh, G150, H2O2, dia5, Mt0, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S85" promotor_-35 complement(220156..220161) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(220211..221122) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388101.1" /db_xref="EnsemblGenomes-Gn:BSU02190" /db_xref="EnsemblGenomes-Tr:CAB12013" /db_xref="GOA:O31446" /db_xref="SubtiList:BG12735" /db_xref="UniProtKB/Swiss-Prot:O31446" /translation="MKNDQIVFEKTKNIAHDINQMQNQQEIIDYLFRQDSLTLNQLKH YYSEPSLPLQFLVKVAVLCMFISMTLASFLFIQAKEVFTNTILSDISPAVFSIFTVIC IFMTYTKIIKKGNKNKGKASLNQRSEFYEKNKLINTILYKKYKMDQQNIQANKHTASD NEDSMNFSAVLNHVLTISKNDKELLGYLDTRDNAMLSQLKAYFSTRPFSLPHYMSLMF CGSIIVVYATSLFSGQINYIDIPHIFIFLLLIIFLKILIDLIKLLNISRKGQLHTVLH FAQRAEYLRMRGVIDFILTERYNKKIM*" /label="ybfF CDS" gene complement(220211..221122) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /label="ybfF gene" S_feature complement(221123..221210) /Source="Nicolas_S_feature" /locus_tag="new_239556_239643_c" /HighExp="LBGexp, Lbexp, G150, dia5, dia0, G135, Oxctl, H2O2, Mt0, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S86" CDS complement(221211..223409) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pepdidoglycan binding protein" /protein_id="NP_388102.1" /db_xref="EnsemblGenomes-Gn:BSU02200" /db_xref="EnsemblGenomes-Tr:CAB12014" /db_xref="GOA:O31447" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG12736" /db_xref="UniProtKB/Swiss-Prot:O31447" /translation="MVDEMVLITQQWLNDTYSGKHGYNPVEESGKTGWDTIYGLTRAL QIELGISEPADNFGPTTQRLFKPLKRQAPDSKPSNMNFILQGALWCKGFNPGGFTGVF YEKTENAVKEFQKAAGLTTQDGIVTTLIMKALLDMSAFKLVSGGDSRIRQIQQNLNRD YNDYIGLMPCDGLYGRDTNKALIYALQKEEGMSTSVANGFFGNGTTSLCPTLTPGDSR TGFVLIVQYALYCNGKSFDPGEFDGKYGVGVVSAVKAFQEFMCLPQTGYADMPTIKAL LSSSGDTTRTASACDTATIITAEKAQTLRNNGYKTVGRYLTGNVRTSSGLTSKALTSK ELAVILDAGLKVFPIYQDGGYESSYFVKDQGTRDAYSAASAARRLGFPSGTTIYFAVD FDAYDYEVTDKIIPYFQEIKSAFTKMQTFSTAPKYEIGVYGPRNICIRTSEAGLTKYS FVANMSTGFSGNLGYPMPNNWAFDQFYEGTIGSGSGSIGIDKDGYSGRDSGASNVNPP SDPVYDARLRTLTDILSTIPALENLTSLANAMFEFDTTETIFTSPELDIILSTSLLAT IPSEGSPNTITITNGKPGAYITGLLGDTQTSLTASQIDSYQNLLNSLSLSVRNGYLEV YVNPTAESLNIQIKIYTPDIPVGDNVTTGLTTTITFKIKTYKGVPVTSPESELALDWP SYDQYLFPVVGVAALLLIGNMGSDLTNNKGVKVATALSAMLLAIFAYYTS*" /label="ybfG CDS" gene complement(221211..223409) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /label="ybfG gene" misc_feature complement(223444..223462) /Source="Nicolas_upshift_promotors" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(223456) /Source="Nicolas_upshifts" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(223484..224404) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388103.1" /db_xref="EnsemblGenomes-Gn:BSU02210" /db_xref="EnsemblGenomes-Tr:CAB12015" /db_xref="GOA:O31448" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12737" /db_xref="UniProtKB/Swiss-Prot:O31448" /translation="MNIQRETSGHIAAIVTILIWGTTFISTKVLLADFSPMEILFYRF LMGFIALILVRPNMIPFRNWRQELLFAGAGLFGVTLYFLLENIALTYTYASNVGMIVS IIPMITAVLAHFLLEGEKLRLTFLIGFISALIGLLLITFNGNVVLRLNPLGDIMAAGA ALVFGGYSIFMKKLSAYEYHIIELTQRVFLYGLLFMVPALFLFDFHFDLSRFSSASNI LNMLFLGIGASALCFATWNYSVGVLGAVKSSAYIYMVPVITIAASVLILHENMTWIAL LGGALTLLGLYISELKPKAKLLENGCKMDA*" /label="ybfH CDS" gene complement(223484..224404) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /label="ybfH gene" CDS complement(224401..225228) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family, cupin family)" /protein_id="NP_388104.1" /db_xref="EnsemblGenomes-Gn:BSU02220" /db_xref="EnsemblGenomes-Tr:CAB12016" /db_xref="GOA:O31449" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12738" /db_xref="UniProtKB/Swiss-Prot:O31449" /translation="MQNETRTLQLDPHLHIEAYRFKGIMQKFPNHFHDYYVIGFIEKG QRYLACQDQEYIINPGDLLLFNPRDTHSCEQIDGRTLDYRCINVMPDIMEKAVKEITG SGHLPYFSQHVLFRHELTASLQELHILISEEKQALRKEELFLHLLEELIRHYSDVTFL SSVPEPSDEVKMVCEFLEEHYAENVTLNDLSELTGWSKYHLLRSFTKQKGITPNSYME TIRINQAKKLLEQGVRPIDAAFQTGFSDQSHMTKFFKRQVGLTPKQYMKIFEKELHR* " /label="ybfI CDS" gene complement(224401..225228) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /label="ybfI gene" misc_feature complement(225255..225274) /Source="Nicolas_upshift_promotors" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(225262) /Source="Nicolas_upshifts" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 225402..225405 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 225420..225439 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 225425 /Source="Nicolas_upshifts" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="upshifts" CDS 225459..226613 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /EC_number="2.1.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496533; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase 2" /protein_id="NP_388105.1" /db_xref="EnsemblGenomes-Gn:BSU02230" /db_xref="EnsemblGenomes-Tr:CAB12017" /db_xref="GOA:P39771" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005862" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10924" /db_xref="UniProtKB/Swiss-Prot:P39771" /translation="MYQSKKVLLLGSGELGKEVVIEAQRLGVQTVAVDSYEHAPAMQV AHNSYVVDMLDPEQIRTIIEKENPDLIVPEVEAIATDELLKLEEEGFHVIPNARAAKL TMDREGIRRLAAETLGLATAGYEFANTYDEFIQAAAQIGFPCVVKPLMSSSGKGQSVC RSEADLESCWETAMEGGRVKNGRVIVEEFIPFESEITLLTVRAVNGTAFCEPIGHVQK DGDYIESWQPHDMTEQQIEEAKHIAKTITDELGGYGLFGVELFLAKDRVYFSEVSPRP HDTGLVTLVTQNLSEFALHVRAILGFPITEITQLSPGASRPLKAPEELADYTVEGLEN ALAVPKTQVRVFGKPITKAGRRMAVALSAADSVETARENAKKALDQLILK*" /label="purT CDS" gene 225459..226613 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /label="purT gene" downshifts 226594 /Source="Nicolas_upshifts" /id="D84" /incds=0 /nref=100 /ntot=189 /MaxReadThrough="2.6996" /MaxDrop="5.22319" /score="39.2561117" /energy="-15.1" /TU="NA" /idTUdmin="U155" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 226674..226679 /Source="Nicolas_upshift_promotors" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="promotor_-35" upshifts 226688 /Source="Nicolas_upshifts" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="upshifts" promotor_-10 226694..226712 /Source="Nicolas_upshift_promotors" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="promotor_-10" promotor_-35 226728..226735 /Source="Nicolas_upshift_promotors" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 226750..226769 /Source="Nicolas_upshift_promotors" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 226750 /Source="Nicolas_upshifts" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="upshifts" CDS 226757..227698 /gene="mpr" /locus_tag="BSU_02240" /old_locus_tag="BSU02240" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15205417, 15375126, 21819557, 25666135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular glutamyl-endopeptidase" /protein_id="NP_388106.1" /db_xref="EnsemblGenomes-Gn:BSU02240" /db_xref="EnsemblGenomes-Tr:CAB12018" /db_xref="GOA:P39790" /db_xref="InterPro:IPR000126" /db_xref="InterPro:IPR001254" /db_xref="InterPro:IPR008256" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR018114" /db_xref="InterPro:IPR028301" /db_xref="SubtiList:BG10690" /db_xref="UniProtKB/Swiss-Prot:P39790" /translation="MKLVPRFRKQWFAYLTVLCLALAAAVSFGVPAKAAENPQTSVSN TGKEADATKNQTSKADQVSAPYEGTGKTSKSLYGGQTELEKNIQTLQPSSIIGTDERT RISSTTSFPYRATVQLSIKYPNTSSTYGCTGFLVNPNTVVTAGHCVYSQDHGWASTIT AAPGRNGSSYPYGTYSGTMFYSVKGWTESKDTNYDYGAIKLNGSPGNTVGWYGYRTTN SSSPVGLSSSVTGFPCDKTFGTMWSDTKPIRSAETYKLTYTTDTYGCQSGSPVYRNYS DTGQTAIAIHTNGGSSYNLGTRVTNDVFNNIQYWANQ*" /label="mpr CDS" gene 226757..227698 /gene="mpr" /locus_tag="BSU_02240" /old_locus_tag="BSU02240" /label="mpr gene" CDS 227661..228059 /gene="ybfJ" /locus_tag="BSU_02250" /old_locus_tag="BSU02250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388107.1" /db_xref="EnsemblGenomes-Gn:BSU02250" /db_xref="EnsemblGenomes-Tr:CAB12019" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR019730" /db_xref="SubtiList:BG12739" /db_xref="UniProtKB/Swiss-Prot:O31451" /translation="MYSTIFNIGQINKYSKLAIFMSILFLCGCSSQTHSSQKETTIPV TLHVEDAKGLPVEGVQVTIVKAPSSDEEPSTEIGEILGKTDKNGDIKWDTGRKGDYSV ALTKGETSVTHHISLTEDKKDHAIPLVFKE*" /label="ybfJ CDS" gene 227661..228059 /gene="ybfJ" /locus_tag="BSU_02250" /old_locus_tag="BSU02250" /label="ybfJ gene" promotor_-10 complement(227753..227767) /Source="Nicolas_upshift_promotors" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(227763) /Source="Nicolas_upshifts" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(227783..227788) /Source="Nicolas_upshift_promotors" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 228046 /Source="Nicolas_upshifts" /id="D85" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.50775" /MaxDrop="5.06025" /score="29.4582027" /energy="-15.4" /TU="U156" /idTUdmin="U157" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 228115..228122 /Source="Nicolas_upshift_promotors" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 228137..228156 /Source="Nicolas_upshift_promotors" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 228150..228224 /Source="Nicolas_S_feature" /locus_tag="new_246583_246657" /HighExp="Cold, LoTm, S0, aero, ferm, T-4.40H, nit, T-5.40H, T-0.40H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S87" upshifts 228150 /Source="Nicolas_upshifts" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="upshifts" CDS 228225..229115 /gene="cesB" /locus_tag="BSU_02260" /old_locus_tag="BSU02260" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11389736, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11389736, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enantioselective carboxylesterase" /protein_id="NP_388108.1" /db_xref="EnsemblGenomes-Gn:BSU02260" /db_xref="EnsemblGenomes-Tr:CAB12020" /db_xref="GOA:O31452" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:4CCY" /db_xref="SubtiList:BG12740" /db_xref="UniProtKB/Swiss-Prot:O31452" /translation="MIQDSMQFAAVESGLRFYQAYDQSLSLWPIESEAFYVSTRFGKT HIIASGPKDAPSLILLHGGLFSSAMWYPNIAAWSSQFRTYAVDIIGDKNKSIPSAAME TRADFAEWMKDVFDSLGLETAHLAGLSLGGSHIVNFLLRAPERVERAVVISPAEAFIS FHPDVYKYAAELTGARGAESYIKWITGDSYDLHPLLQRQIVAGVEWQDEQRSLKPTEN GFPYVFTDQELKSIQVPVLLMFGEHEAMYHQQMAFERASVLVPGIQAEIVKNAGHLLS LEQPEYVNQRVLSFLCGGIK*" /label="cesB CDS" gene 228225..229115 /gene="cesB" /locus_tag="BSU_02260" /old_locus_tag="BSU02260" /label="cesB gene" promotor_-35 228459..228466 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 228475 /Source="Nicolas_upshifts" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 228480..228498 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 229116..229310 /Source="Nicolas_S_feature" /locus_tag="new_247549_247743" /HighExp="Cold, LBGstat, Paraq, Oxctl, H2O2, dia15, G135, Diami, Lbexp, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.867, 1" /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S88" CDS 229311..229844 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /EC_number="2.7.8.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 15743965, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 15743965, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine synthase" /protein_id="NP_388109.1" /db_xref="EnsemblGenomes-Gn:BSU02270" /db_xref="EnsemblGenomes-Tr:CAB12021" /db_xref="GOA:P39823" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004533" /db_xref="SubtiList:BG11012" /db_xref="UniProtKB/Swiss-Prot:P39823" /translation="MNYIPCMITIGNFICGLLAIHSLLYHNIHSAVLFIFTGMFLDFF DGMAARKLNAVSDMGRELDSFADLVTFGVAPSMLAYSVALYTLPFIGILCALTYSICG MLRLSKFNIEQSKLPTFIGMPIPFAGMCLVILSFTYNPILLAIGTCGLSYLMVSKIKF PHFKKHAAENLESGRWN*" /label="pssA CDS" gene 229311..229844 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /label="pssA gene" CDS 229835..230323 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 14762009, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane phosphatase" /protein_id="NP_388110.1" /db_xref="EnsemblGenomes-Gn:BSU02280" /db_xref="EnsemblGenomes-Tr:CAB12022" /db_xref="GOA:O31453" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG12741" /db_xref="UniProtKB/Swiss-Prot:O31453" /translation="MELVQQLIADYGYLAIFLMLVLGIVGLPIPDEVMMTVVGYFTHT DVLNYELSILISFVGALLGMLISYMIGRKAGRPFIDKYGKWVGLKEKRMMKVEKWMKK YGPYSLILGYFIPGVRHVTCYFSGIGKMDLKTYVAFAAIGAFLWCFVFITIGRVIGII HV*" /label="ybfM CDS" gene 229835..230323 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /label="ybfM gene" CDS 230316..231107 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /EC_number="4.1.1.65" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 9422599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 9422599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine decarboxylase; 32 kDa precursor processed into a 29 kDa protein" /protein_id="NP_388111.1" /db_xref="EnsemblGenomes-Gn:BSU02290" /db_xref="EnsemblGenomes-Tr:CAB12023" /db_xref="GOA:P39822" /db_xref="InterPro:IPR003817" /db_xref="InterPro:IPR033177" /db_xref="InterPro:IPR033178" /db_xref="SubtiList:BG11013" /db_xref="UniProtKB/Swiss-Prot:P39822" /translation="MFNTAVKILYRSLIELTNHRLSSYLIKGFCESKISKPVIPLFSK HFRLNWDDVDGTAADYGSLSELFIRQINLERRPVSKEAHAVVSPVDGVVQTVGIINPN QTFTVKGKDYSFAELTGCKSADHQYNGGYFVVLYLSPRHYHRFHSPISCRYQKLAELG NRSYPVNQLGLKYGKDVLSKNYRFVYELNSGSRNVLMIPVGAMNINSIVQTNTRTELE IGEELGYFSFGSTVILVFEKDAFQPSAHLAEGQEVQVGELIGYEE*" /label="psd CDS" gene 230316..231107 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /label="psd gene" downshifts 231082 /Source="Nicolas_upshifts" /id="D86" /incds=0 /nref=101 /ntot=236 /MaxReadThrough="3.18138" /MaxDrop="4.25536" /score="-2.98360164" /energy="-8" /TU="U159" /idTUdmin="U160" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 231162..231440 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388112.1" /db_xref="EnsemblGenomes-Gn:BSU02300" /db_xref="EnsemblGenomes-Tr:CAB12024" /db_xref="SubtiList:BG12742" /db_xref="UniProtKB/Swiss-Prot:O31454" /translation="MEKQIISWITDYQNTGDEAVLRQVREVCWPIVEAVLQEKVMDDE QANNLREKGIERFPFIISKYQADVQLPVETFLQNTYRFYFHQVMRESS*" /label="ybfN CDS" gene 231162..231440 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /label="ybfN gene" promotor_-35 231483..231492 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 231501 /Source="Nicolas_upshifts" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 231505..231520 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 231546..232886 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_388113.1" /db_xref="EnsemblGenomes-Gn:BSU02310" /db_xref="EnsemblGenomes-Tr:CAB12025" /db_xref="GOA:O31455" /db_xref="InterPro:IPR007815" /db_xref="SubtiList:BG12743" /db_xref="UniProtKB/Swiss-Prot:O31455" /translation="MKRMIVRMTLPLLIVCLAFSSFSASARAASEEKYWDHWIERHAQ PLDASNASNKDLRFLKKVLKGKRIVQLGETTHGAGEINATKVRMIKYLHEELGYDVLA FESGFPDTNASYLNMDQLTPKSTMKNSIYAVWHTEDVVELFDYMKEQKEKGDPLILTG FDIQSMKNSFNVAATQWVKAVDPEKAELLSQSENDFSTLVTDSNTFDEFSQKKEKLVK NYQKLIKFTKTHASELKENLPKEPKAYEMFMHSLQLRIDVMETYMLEEMKEKLEEYPE NIEDFSFFMRDRMMAEQFQWVADTLYPKKKIIVWGHNYHLRKQNTKMIKDWVQLNGPN MGDYLPERLKKQTYTIGIYAYSGASLDSSDNKTVKPVTSPPPSGSLEALLKAADRPAV FVDFLHTKNKKGTSWMYTPRTALYWGYMEEQMILKEQYDGVIWLEHITPSVIIK*" /label="ybfO CDS" gene 231546..232886 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /label="ybfO gene" downshifts 232886 /Source="Nicolas_upshifts" /id="D87" /incds=0 /nref=12 /ntot=60 /MaxReadThrough="3.64301" /MaxDrop="6.34998" /score="14.4442651" /energy="-13.3" /TU="U161" /idTUdmin="U162" /TUdmin="-1122" /isTUend="FALSE" /label="downshifts" upshifts 232952 /Source="Nicolas_upshifts" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="upshifts" misc_feature 232955..232974 /Source="Nicolas_upshift_promotors" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 232994..233881 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388114.1" /db_xref="EnsemblGenomes-Gn:BSU02320" /db_xref="EnsemblGenomes-Tr:CAB12026" /db_xref="GOA:O31456" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12744" /db_xref="UniProtKB/Swiss-Prot:O31456" /translation="MYYEKAVQKTINWIESHLHEQISNEDIVNVSSFSKFHFHRIFQK EVGMSVASYIRLRRLANAAAALLYTDHRIIDIALYYQFESQEAFTRTFKKMYHMPPGA YRTFMKRFTSKKEESYMEKKMKGWVLSGSHPFQFEMGIDRENVHQGKASGYLKSTMVQ DIGEFATMMQQFKADRYLGKRLRLSSFIKTKGVQHFASLWMRVDSAADDVLQFDNMSN RPITGTTNWNHYAIVLDVPENSAVISFGVQLSGPGQVWMDHVVFEEVDESVPSTNLEM PGELLDEPVNLSFEEELQK*" /label="ybfP CDS" gene 232994..233881 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /label="ybfP gene" S_feature 233882..234025 /Source="Nicolas_S_feature" /locus_tag="new_252315_252458" /HighExp="T0.30H, T-1.40H, T0.0H, T-1.10H, Salt, aero, ferm, T-0.40H, T-2.40H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.838, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S89" promotor_-35 233997..234004 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 234018..234037 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 234027 /Source="Nicolas_upshifts" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 234081..235049 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with rhodanese domain" /protein_id="NP_388115.1" /db_xref="EnsemblGenomes-Gn:BSU02330" /db_xref="EnsemblGenomes-Tr:CAB12027" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR020936" /db_xref="InterPro:IPR022111" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG12745" /db_xref="UniProtKB/Swiss-Prot:O31457" /translation="MEKQYRVLLYYKYVPIEDPEAFREQHLAFCKELGLLGRILVSSE GINGTVSGTVEQTEKYMETMKADPRFADMVFKIDEAEGHAFKKIFVRHKKELVTLRLE DDVDPNETTGQHLKPAEFYEKMQDPNTIVIDARNDYEYDLGHFRGAVRPDIEAFRELP EWIEEHKDMLEGKKILTYCTGGVRCEKFSGWLVKQGFEDVAQLDGGIVTYGKDPEVQG KLWDGQCYVFDERISVPVNRVEHVIVGKDYFTGEPCERYVNCANPSCNKKMICTPENE YKYMRSCSHECRTNPRNLYVKEHNMTEEEVNARLAAIETEDHAAAE*" /label="ybfQ CDS" gene 234081..235049 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /label="ybfQ gene" promotor_-10 complement(234903..234921) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(234920) /Source="Nicolas_upshifts" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(234937..234942) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 235046 /Source="Nicolas_upshifts" /id="D88" /incds=0 /nref=238 /ntot=271 /MaxReadThrough="2.06825" /MaxDrop="7.49655" /score="4.11635522" /energy="-7.8" /TU="U163" /idTUdmin="U161" /TUdmin=4 /isTUend="TRUE" /label="downshifts" downshifts complement(235085) /Source="Nicolas_upshifts" /id="D89" /incds=0 /nref=59 /ntot=147 /MaxReadThrough="0.54212" /MaxDrop="6.33244" /score="2.56774646" /energy="-7.5" /TU="NA" /idTUdmin="U165" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(235085..236329) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7751298, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7751298, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/glutamate symport protein" /protein_id="NP_388116.1" /db_xref="EnsemblGenomes-Gn:BSU02340" /db_xref="EnsemblGenomes-Tr:CAB12028" /db_xref="GOA:P39817" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11015" /db_xref="UniProtKB/Swiss-Prot:P39817" /translation="MKKLIAFQILIALAVGAVIGHFFPDFGMALRPVGDGFIRLIKMI VVPIVFSTIVIGAAGSGSMKKMGSLGIKTIIWFEVITTLVLGLGLLLANVLKPGVGLD LSHLAKKDIHELSGYTDKVVDFKQMILDIIPTNIIDVMARNDLLAVIFFAILFGVAAA GIGKASEPVMKFFESTAQIMFKLTQIVMVTAPIGVLALMAASVGQYGIELLLPMFKLV GTVFLGLFLILFVLFPLVGLIFQIKYFEVLKMIWDLFLIAFSTTSTETILPQLMDRME KYGCPKRVVSFVVPSGLSLNCDGSSLYLSVSCIFLAQAFQVDMTLSQQLLMMLVLVMT SKGIAAVPSGSLVVLLATANAVGLPAEGVAIIAGVDRVMDMARTGVNVPGHAIACIVV SKWEKAFRQKEWVSANSQTESI*" /label="gltP CDS" gene complement(235085..236329) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /label="gltP gene" promotor_-10 complement(236363..236381) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(236372) /Source="Nicolas_upshifts" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(236392..236400) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(236400..236418) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(236416) /Source="Nicolas_upshifts" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(236434..236439) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(236474..238369) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /EC_number="2.7.1.193" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10627040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucosamine-specific enzyme IICBA component" /protein_id="NP_388117.1" /db_xref="EnsemblGenomes-Gn:BSU02350" /db_xref="EnsemblGenomes-Tr:CAB12029" /db_xref="GOA:P39816" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11014" /db_xref="UniProtKB/Swiss-Prot:P39816" /translation="MFKKAFQILQQLGRALMTPVAVLPAAGLLLRFGDKDLLNIPIIK DAGGVVFDNLPLIFAVGVAIGLAGGEGVAGLAAVIGYLILTVTLDNMGKLLGLQPPYE GAEHLIDMGVFGGIIIGLLAAYLYKRFSSIELHPVLGFFSGKRFVPIITSVSSLVIGV IFSFVWPLIQNGINAASSLIADSTVGLFFYATIYRLLIPFGLHHIFYTPFYFMMGEYT DPSTGNTVTGDLTRFFAGDPTAGRFMMGDFPYMIFCLPAVALAIIHTARPEKKKMISG VMISAALTSMLTGITEPVEFSFLFVAPVLYLINSILAGVIFVVCDLFHVRHGYTFSGG GIDYVLNYGLSTNGWVVIPVGIVFAFIYYYLFRFAILKWNLKTPGRETDEDGQNEEKA PVAKDQLAFHVLQALGGQQNIANLDACITRLRVTVHQPSQVCKDELKRLGAVGVLEVN NNFQAIFGTKSDALKDDIKTIMAGGVPATAAALDTVTDKPLKPDSDETFIYPIKGETV SLGDVPDQVFSEKMMGEGFAIIPSEGKVVAPADGEIVSIFPTKHAIGFMSAGGTEILI HVGIDTVKLNGEGFEAHVTSGQAVKQGELLLTFDLNYIKQHAASAITPVIFTNTSEED LKHIQMK*" /label="gamP CDS" gene complement(236474..238369) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /label="gamP gene" downshifts complement(236490) /Source="Nicolas_upshifts" /id="D90" /incds=0 /nref=56 /ntot=192 /MaxReadThrough="1.9947" /MaxDrop="6.51864" /score="5.87664177" /energy="-12.1" /TU="NA" /idTUdmin="U168" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" misc_feature 238235..238254 /Source="Nicolas_upshift_promotors" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 238252 /Source="Nicolas_upshifts" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(238390..239139) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /EC_number="3.5.99.6" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:23667565, 27002132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 27002132; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate deaminase" /protein_id="NP_388118.1" /db_xref="EnsemblGenomes-Gn:BSU02360" /db_xref="EnsemblGenomes-Tr:CAB12030" /db_xref="GOA:O31458" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="SubtiList:BG12746" /db_xref="UniProtKB/Swiss-Prot:O31458" /translation="MKILIAEHYEELCKLSAAIIKEQIQAKKDAVLGLATGSTPVGLY KQLISDYQAGEIDFSKVTTFNLDEYAGLSPSHPQSYNHFMHEHLFQHINMQPDHIHIP QGDNPQLEAACKVYEDLIRQAGGIDVQILGIGANGHIGFNEPGSDFEDRTRVVKLSES TIQANARFFGGDPVLVPRLAISMGIKTIMEFSKHIVLLASGEEKADAIQKMAEGPVTT DVPASILQKHNHVTVIADYKAAQKLKSASFS*" /label="gamA CDS" gene complement(238390..239139) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /label="gamA gene" S_feature 239112..239293 /Source="Nicolas_S_feature" /locus_tag="new_257545_257726" /HighExp="H2O2, T1.30H, G135, dia15, G150, G180, LBGstat, T2.0H, T0.30H, M9-stat" /AntisenseName="nagBB" /AntisenseCor="0.458837556034909" /AntisenseRegPval="-14.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S90" S_feature complement(239140..239210) /Source="Nicolas_S_feature" /locus_tag="new_257573_257643_c" /HighExp="S1, Diami, MG 5, MG t5, dia5, MG 15, MG 10, LPhT, Paraq, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S91" promotor_-10 complement(239199..239218) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(239214) /Source="Nicolas_upshifts" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(239234..239241) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 239280..239287 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 239295 /Source="Nicolas_upshifts" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 239300..239319 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 239358..240065 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23667565, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator-GlcN6P (GntR family)" /protein_id="NP_388119.1" /db_xref="EnsemblGenomes-Gn:BSU02370" /db_xref="EnsemblGenomes-Tr:CAB12031" /db_xref="GOA:O31459" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12747" /db_xref="UniProtKB/Swiss-Prot:O31459" /translation="MTALYSVIKFKIIELIKSGKYQANDQLPTESEFCEQYDVSRTTV RLALQQLELEGYIKRIQGKGTFVSAAKIQTPIPHKITSFAEQMRGLRSESKVLELVVI PADHSIAELLKMKENEPVNKLVRVRYAEGEPLQYHTSYIPWKAAPGLAQEECTGSLFE LLRTKYNIEISRGTESIEPILTDETISGHLLTNVGAPAFLSESLTYDKNEEVVEYAQI ITRGDRTKFTVEQSYHS*" /label="gamR CDS" gene 239358..240065 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /label="gamR gene" promotor_-35 240031..240032 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 240048..240062 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 240058 /Source="Nicolas_upshifts" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="upshifts" CDS 240099..240374 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12897008, 23667565" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (B. subtilis-specific)" /protein_id="NP_388120.1" /db_xref="EnsemblGenomes-Gn:BSU02380" /db_xref="EnsemblGenomes-Tr:CAB12032" /db_xref="GOA:O31460" /db_xref="InterPro:IPR012867" /db_xref="SubtiList:BG12748" /db_xref="UniProtKB/Swiss-Prot:O31460" /translation="MFLFTNGKVLWGAVIAAFILSIVFYPFLPTQMPIHYDVANSPDL TVNKLAGTVMLPVLMVVFAWARKINWQFVFAVYILLICHIVVLCLAL*" /label="ybgB CDS" gene 240099..240374 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /label="ybgB gene" promotor_-10 complement(240157..240175) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(240163) /Source="Nicolas_upshifts" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(240190..240196) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 240366 /Source="Nicolas_upshifts" /id="D91" /incds=0 /nref=20 /ntot=130 /MaxReadThrough="2.42422" /MaxDrop="3.75723" /score="4.58454735" /energy="-9.4" /TU="NA" /idTUdmin="U169" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 240417..240421 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 240437..240456 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 240443 /Source="Nicolas_upshifts" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="upshifts" S_feature 240454..240582 /Source="Nicolas_S_feature" /locus_tag="new_258887_259015" /HighExp="T2.30H, S5, T2.0H, T1.30H, M9-stat, T3.0H, T3.30H, S4, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S92" CDS 240583..241653 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15060025, 15102328, 20332210, 23429746" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15060025, 15102328, 20332210, 23429746; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucine-valine aminotransferase / aromatic amino acid aminotransferase" /protein_id="NP_388121.1" /db_xref="EnsemblGenomes-Gn:BSU02390" /db_xref="EnsemblGenomes-Tr:CAB12033" /db_xref="GOA:O31461" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG12749" /db_xref="UniProtKB/Swiss-Prot:O31461" /translation="MNKLIEREKTVYYKEKPDPSSLGFGQYFTDYMFVMDYEEGIGWH HPRIAPYAPLTLDPSSSVFHYGQAVFEGLKAYRTDDGRVLLFRPDQNIKRLNRSCERM SMPPLDEELVLEALTQLVELEKDWVPKEKGTSLYIRPFVIATEPSLGVKASRSYTFMI VLSPVGSYYGDDQLKPVRIYVEDEYVRAVNGGVGFAKTAGNYAASLQAQRKANELGYD QVLWLDAIEKKYVEEVGSMNIFFVINGEAVTPALSGSILSGVTRASAIELIRSWGIPV REERISIDEVYAASARGELTEVFGTGTAAVVTPVGELNIHGKTVIVGDGQIGDLSKKL YETITDIQLGKVKGPFNWTVEV*" /label="ilvE CDS" gene 240583..241653 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /label="ilvE gene" downshifts 241642 /Source="Nicolas_upshifts" /id="D92" /incds=0 /nref=124 /ntot=245 /MaxReadThrough="1.34575" /MaxDrop="6.88046" /score="13.1364544" /energy="-9.4" /TU="NA" /idTUdmin="U172" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(241690..243102) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid permease" /protein_id="NP_388122.1" /db_xref="EnsemblGenomes-Gn:BSU02400" /db_xref="EnsemblGenomes-Tr:CAB12034" /db_xref="GOA:O31462" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12750" /db_xref="UniProtKB/Swiss-Prot:O31462" /translation="MNSAHNKNETTFQRSMKSRHLFMLSLGGVIGTGLFLSSGYTIQQ AGPAGTILAYLVGAGIVYLVMLCLGELSVAMPVTGAFHTYAAKYIGPGTGFTVAWLYW LTWTVALGSEFTAAGLLMQRWFPHTSVWMWSAVFALFIFLLNAFSVKFFAESEFWFSS IKVLAIVLFILLGGSAMFGIIPIKGGEAAPMLSNFTAEGGLFPNGFVPILMTMLSVNF AFSGTELIGIAAGESVDPDKTIPKAIKTTVWRLSLFFVGTIFVLSGLIPIQDAGVIKS PFVAVFDRVGVPYAADIMNFVILTAILSAANSGLYASSRMLWSLSKEKTLHPTFAKLT SKGTPFNALVFSMIGGILSLLSSVFAPDTVYVVLVSISGFAVVVVWMGIAASQFMFRK RYIEAGNKVTDLKYRTPLYPFVPIAAFLLCLASVVGIAFDPNQRIALYCGVPFMAICY AIYYVKNRKSQPAADMTHSK*" /label="ybgF CDS" gene complement(241690..243102) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /label="ybgF gene" downshifts complement(241707) /Source="Nicolas_upshifts" /id="D93" /incds=0 /nref=43 /ntot=166 /MaxReadThrough="0.37503" /MaxDrop="5.92001" /score="6.94246417" /energy="-9.4" /TU="NA" /idTUdmin="U173" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(243103..243214) /Source="Nicolas_S_feature" /locus_tag="new_261536_261647_c" /HighExp="BMM, S1, MG 45, MG 60, UNK1, MG t5, MG 10, MG 90, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S93" promotor_-10 complement(243187..243206) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(243214) /Source="Nicolas_upshifts" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(243221..243228) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(243223..244170) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11267663, 15995196, 17264075; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homocysteine methylase using (R,S)AdoMet" /protein_id="NP_388123.1" /db_xref="EnsemblGenomes-Gn:BSU02410" /db_xref="EnsemblGenomes-Tr:CAB12035" /db_xref="GOA:O31463" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR017226" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG12751" /db_xref="UniProtKB/Swiss-Prot:O31463" /translation="MNPIQHILDTYPLIVLDGAMATELERKGCNLNDSLWSAKILMEE PELIKQVHTDYFAAGADCAITASYQSTFEGFAARGLSEAEARRLIELSVSIAAEARDE FWSLEENRLNRPKPIIAASIGPYGAYLADGSEYRGNYAISEDELIEFHRPRMKALIEA GADVLACETIPCLTEAKAIVRLLKEFPETYAWISFSAKDGLHISDGTPAADCASWLDE HRQIAALGINCTPLQHIPSLIEELKKNTSKPIIVYPNSGEQYDPETKTWNGAACAESY GASARTWHEKGARLIGGCCRTKPENIQEIAAWARSLKTT*" /label="ybgG CDS" gene complement(243223..244170) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /label="ybgG gene" promotor_-10 complement(244208..244227) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-10" upshifts complement(244225) /Source="Nicolas_upshifts" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="upshifts" promotor_-35 complement(244242..244249) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-35" CDS complement(244299..245735) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 15995196, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine transporter" /protein_id="NP_388124.2" /db_xref="EnsemblGenomes-Gn:BSU02420" /db_xref="EnsemblGenomes-Tr:CAB12036" /db_xref="GOA:O31464" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12752" /db_xref="UniProtKB/Swiss-Prot:O31464" /translation="MQQILEHIVGIANDLLWSKLLIVLLLSFGIYFTFRLKFLQVRML KEMVRVLREGAASRSKNSISPFQAFCISMAARVGTGNITGIAIAIALGGPGAIFWMWI IAIIGSASSFVESTLAQIYKVKDVNGFRGGPAYYMEKGLNKRWMGALFAVLITLSFGI VFNSVQSNTVSLAFENAFGTNRLTLGLILIAVFGTIIFGGVKRIAKLAESIVVVLAVL YIGVAFFVIFSNITQLPGVLALIVKNAFGFDQAAGGALGAALMQGVRRGIFSNEAGMG SAPNAAATATTSHPVKQGLIQAFGVLTDTLVICTSTAFIILFSDAYHTPGLSGIALTQ ASLSSHVGSWASGFLAILILLFGFCALIGNYYYGETNIGFLNKSKKLIFVYRIGVLAM IVFGCVAKVQLVWDLADLFMGLMVIVNLIAIFLLSKVVFTALKDYTRQKKAGKDPVFY KDVLKNHNGIECWPVSDTKTDTHNKQIS*" /label="glnT CDS" gene complement(244299..245735) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /label="glnT gene" downshifts complement(244314) /Source="Nicolas_upshifts" /id="D94" /incds=0 /nref=3 /ntot=3 /MaxReadThrough="0.598370000000001" /MaxDrop="4.3935" /score="-7.90227391" /energy="-11.4" /TU="NA" /idTUdmin="U174" /TUdmin="-1078" /isTUend="FALSE" /label="downshifts" CDS complement(245758..246741) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15995196, 18459799, 20050917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995196, 18459799, 20050917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutaminase" /protein_id="NP_388125.1" /db_xref="EnsemblGenomes-Gn:BSU02430" /db_xref="EnsemblGenomes-Tr:CAB12037" /db_xref="GOA:O31465" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="PDB:1MKI" /db_xref="PDB:2OSU" /db_xref="PDB:3AGF" /db_xref="PDB:3BRM" /db_xref="SubtiList:BG12753" /db_xref="UniProtKB/Swiss-Prot:O31465" /translation="MKELIKEHQKDINPALQLHDWVEYYRPFAANGQSANYIPALGKV NDSQLGICVLEPDGTMIHAGDWNVSFTMQSISKVISFIAACMSRGIPYVLDRVDVEPT GDAFNSIIRLEINKPGKPFNPMINAGALTIASILPGESAYEKLEFLYSVMETLIGKRP RIHEEVFRSEWETAHRNRALAYYLKETNFLEAEVEETLEVYLKQCAMESTTEDIALIG LILAHDGYHPIRHEQVIPKDVAKLAKALMLTCGMYNASGKYAAFVGVPAKSGVSGGIM ALVPPSARREQPFQSGCGIGIYGPAIDEYGNSLTGGMLLKHMAQEWELSIF*" /label="glsA CDS" gene complement(245758..246741) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /label="glsA gene" promotor_-10 complement(246835..246852) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 246840..246859 /Source="Nicolas_upshift_promotors" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(246842) /Source="Nicolas_upshifts" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 246846 /Source="Nicolas_upshifts" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(246868..246875) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 247043..248275 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196, 17001076, 21435182, 23461034, 25691471; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [GlnL] forglutamine degradation" /protein_id="NP_388126.2" /db_xref="EnsemblGenomes-Gn:BSU02440" /db_xref="EnsemblGenomes-Tr:CAB12038" /db_xref="GOA:P40758" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10871" /db_xref="UniProtKB/Swiss-Prot:P40758" /translation="MLITVPLAGELKFYPLNEEFRVSFGAPVFFFFLSLLRHVPAVLP GFLTGAAVFIFRVFLELWGGGHNGLTPILYDQASGFFFYMTYACLFSILKANRFRERP IMLGFIGFMIEVVSDCVELTVQFLIFHTVVTPEKITDIAVIAISHTFIVMSFYSVLKL YETQSREKQTRQQHEHMLMIVSNLYEETVHLKKTLKTTEKVTNDSYQLYREMKGKDVQ LSGRILRLAGEIHEVKKDNQRIFAGLSKLISNESLRDYMRASDLLQLVIRMNEKYAEA LGKQIDFYCSIEGEHDEYHVFIVLSIINNLTANAVEAMDEEGMVSLRLRKPNESMVEF QVEDNGPGISEKIGDIVFDPGFTSKYDEFGTPSTGIGLSYVKEIVTELEGDITFDNQQ RGVVFAIRLPVRHLIQKG*" /label="glnJ CDS" gene 247043..248275 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /label="glnJ gene" CDS 248286..249230 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [GlnJ] for glutamine utilisation" /protein_id="NP_388127.1" /db_xref="EnsemblGenomes-Gn:BSU02450" /db_xref="EnsemblGenomes-Tr:CAB12039" /db_xref="GOA:P40759" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013972" /db_xref="SubtiList:BG10872" /db_xref="UniProtKB/Swiss-Prot:P40759" /translation="MRFFIADDDRAVRSILRQIIEDEDLGEAAGEADDGSQVEGHMLQ FKQIDILLIDLLMPGRDGIETIRQIQNTYSGKIVMISQVEAKEMVGEAYSLGIEYFIH KPINRIEIVTVLQKVKERIELEHSIGAIQHSLSRLVNRTERKARPQQKSDSGLKEAGT FLLSELGMMGEGGAHDLMAVLQYLAEHEQSEPHEKQSPSLKQIFTQVAVRKLGTGASQ TEVNREMKASEQRIRRAIIHSLHHFASLGTTDFSNPKFETYASKFFDFPVVSQKMKEL QSKDAKPLAPARINMKKFIHVFFLEAKLLHETMKQRRI*" /label="glnL CDS" gene 248286..249230 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /label="glnL gene" downshifts 249207 /Source="Nicolas_upshifts" /id="D95" /incds=0 /nref=45 /ntot=191 /MaxReadThrough="1.43757" /MaxDrop="3.64091" /score="2.73020459" /energy="-6.2" /TU="NA" /idTUdmin="U177" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" promotor_-35 249327..249334 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 249339..249456 /Source="Nicolas_S_feature" /locus_tag="new_267772_267889" /HighExp="Sw, BC, M40t90, Etha, MG-0.2, HiTm, HiOs, G135, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S94" upshifts 249339 /Source="Nicolas_upshifts" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 249348..249367 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 249457..250383 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /EC_number="4.2.1.41" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5-dehydro-4-deoxyglucarate dehydratase" /protein_id="NP_388128.2" /db_xref="EnsemblGenomes-Gn:BSU02460" /db_xref="EnsemblGenomes-Tr:CAB12040" /db_xref="GOA:P42235" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017655" /db_xref="SubtiList:BG11158" /db_xref="UniProtKB/Swiss-Prot:P42235" /translation="MSRIRKAPAGILGFPVAPFNTQGKLEEEALFQNIEFLLNEGLEA IFIACGSGEFQSLSQKEYEQMVEVAVSAAGGKVPVYTGVGGNLSTALDWAQLSEKKGA DGYLILPPYLVHGEQEGLYQYAKTIIESTDLNAILYQRDNAVLSVEQIKRLTECEQLV GVKDGVGNMDLNINLVYTIGDRLGWLNGMPMAEVTMPAYLPIGFHSYSSAISNYIPHI SRMFYDALKNGNDELVKELYRHVILPINDIRKQRKGYAVSLIKAGMEIMGLNVRNTAR PPVGPVEKDHYQQLEAILKQAADRFPKKAATV*" /label="kdgD CDS" gene 249457..250383 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /label="kdgD gene" CDS 250413..251879 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /EC_number="1.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674, 17202142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,5-dioxovalerate dehydrogenase (alpha-ketoglutaric semialdehyde dehydrogenase)" /protein_id="NP_388129.1" /db_xref="EnsemblGenomes-Gn:BSU02470" /db_xref="EnsemblGenomes-Tr:CAB12041" /db_xref="GOA:P42236" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11159" /db_xref="UniProtKB/Swiss-Prot:P42236" /translation="MSVITEQNTYLNFINGEWVKSQSGDMVKVENPADVNDIVGYVQN STAEDVERAVTAANEAKTAWRKLTGAERGQYLYKTADIMEQRLEEIAACATREMGKTL PEAKGETARGIAILRYYAGEGMRKTGDVIPSTDKDALMFTTRVPLGVVGVISPWNFPV AIPIWKMAPALVYGNTVVIKPATETAVTCAKIIACFEEAGLPAGVINLVTGPGSVVGQ GLAEHDGVNAVTFTGSNQVGKIIGQAALARGAKYQLEMGGKNPVIVADDADLEAAAEA VITGAFRSTGQKCTATSRVIVQSGIYERFKEKLLQRTKDITIGDSLKEDVWMGPIASK NQLDNCLSYIEKGKQEGASLLIGGEKLENGKYQNGYYVQPAIFDNVTSEMTIAQEEIF GPVIALIKVDSIEEALNIANDVKFGLSASIFTENIGRMLSFIDEIDAGLVRINAESAG VELQAPFGGMKQSSSHSREQGEAAKDFFTAIKTVFVKP*" /label="gucD CDS" gene 250413..251879 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /label="gucD gene" CDS 251963..253330 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12044674, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucarate transporter" /protein_id="NP_388130.2" /db_xref="EnsemblGenomes-Gn:BSU02480" /db_xref="EnsemblGenomes-Tr:CAB12042" /db_xref="GOA:P42237" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11160" /db_xref="UniProtKB/Swiss-Prot:P42237" /translation="MKKDFASVTPAGKKTSVRWFIVFMLFLVTSINYADRATLSITGD SVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQ GAIGFFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQY FAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWLKTVYEPKKHPKVNEAELAYI EQGGGLISMDDSKSKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVY LVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFARKVPIIAGMLL SCSMIVCNYTDSAWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGN IASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYLLLVGPIKRVVLKKQEQDPD QSLPV*" /label="gudP CDS" gene 251963..253330 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /label="gudP gene" CDS 253367..254734 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /EC_number="4.2.1.40" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772161, 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucarate dehydratase" /protein_id="NP_388131.2" /db_xref="EnsemblGenomes-Gn:BSU02490" /db_xref="EnsemblGenomes-Tr:CAB12043" /db_xref="GOA:P42238" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR017653" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR034598" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11161" /db_xref="UniProtKB/Swiss-Prot:P42238" /translation="MSSPIQEQVQKEKRSNIPSISEMKVIPVAGHDSMLLNLSGAHSP FFTRNIVILTDSSGNQGVGEVPGGEHIRRTLELSEPLVVGKSIGAYQAILQTVRKQFG DQDRGGRGNQTFDLRTTVHAVTALEAALLDLLGKFLQEPVAALLGEGKQRDEVKMLGY LFYIGDRNRTTLPYQSDEQSDCAWFRLRHEEALTPEAIVRLAESAQERYGFQDFKLKG GVLRGEEEIEAVTALSKRFPEARITLDPNGAWSLEEAIALCKGKQDVLAYAEDPCGDE NGYSAREVMAEFRRATGLPTATNMIATDWREMGHAIQLHAVDIPLADPHFWTMQGSVR VAQMCHDWGLTWGSHSNNHFDISLAMFTHVAAAAPGRITAIDTHWIWQDGQRLTKQPF EISSGCVKVPDKPGLGVDIDMEQVEKAHEIYRKMNLGARNDAIPMQFLISNWEFDRKR PCLVR*" /label="gudD CDS" gene 253367..254734 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /label="gudD gene" promotor_-35 254748..254755 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-35" promotor_-10 254770..254787 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-10" upshifts 254773 /Source="Nicolas_upshifts" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="upshifts" CDS 254804..255505 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12044674" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_388132.2" /db_xref="EnsemblGenomes-Gn:BSU02500" /db_xref="EnsemblGenomes-Tr:CAB12044" /db_xref="GOA:P42239" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11162" /db_xref="UniProtKB/Swiss-Prot:P42239" /translation="MYEGLEDLKVDTVNRKTLAKQVIERIVHLLSSGQLRAGDKLPTE MELMDILHVSRPVLREALSSLETLGVITRKTRGGTYFNDKIGMQPFSVMLALATDNLP AIIEARMALELGLVTIAAEKINEEELQRLQKTIDDIANSTDNHYGEADKEFHRIIALS ANNPVVEGMIQSLLITHAKIDSQIPYRERDVTVEYHKKIYDALAKRDPYKAHYHMYEH LKFVRDKILKGMDEK*" /label="garR CDS" gene 254804..255505 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /label="garR gene" downshifts 255455 /Source="Nicolas_upshifts" /id="D96" /incds=0 /nref=1 /ntot=35 /MaxReadThrough="3.59234" /MaxDrop="2.3923" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1694" /isTUend="FALSE" /label="downshifts" downshifts 255499 /Source="Nicolas_upshifts" /id="D97" /incds=0 /nref=1 /ntot=82 /MaxReadThrough="3.21794" /MaxDrop="2.49226" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1650" /isTUend="FALSE" /label="downshifts" CDS 255596..257128 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /EC_number="4.2.1.42" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772162; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-galactarate dehydratase" /protein_id="NP_388133.2" /db_xref="EnsemblGenomes-Gn:BSU02510" /db_xref="EnsemblGenomes-Tr:CAB12045" /db_xref="GOA:P42240" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR017654" /db_xref="SubtiList:BG11163" /db_xref="UniProtKB/Swiss-Prot:P42240" /translation="MAMNLRKNQAPLYIKVHEIDNTAIIVNDGGLPKGTVFSCGLVLE EDVPQGHKVALTDLNQGDEIVRYGEVIGFADETIKRGSWIREALVRMPAPPALDDLPL ANRVPQPRPPLEGYTFEGYRNADGSAGTKNILGITTSVQCVVGVLDYAVKRIKEELLP KYPNVDDVVPLHHQYGCGVAINAPDAVIPIRTIQNLAKHPNFGGEVMVIGLGCEKLLP ERIASENDDDILSLQDHRGFAAMIQSILEMAEERLIRLNSRTRVSCPVSDLVIGLQCG GSDAFSGVTANPAVGYAADLLVRAGATVLFSEVTEVRDAIHLLTPRAVSEEVGQSLIK EMKWYDSYLRRGDADRSANPSPGNKKGGLSNVVEKALGSVAKSGTSPISGVLGPGERA KQKGLLFAATPASDFVCGTLQLAAGMNLQVFTTGRGTPYGLAAAPVLKVSTRHSLSEH WADLIDINAGRIATGEASIEDVGWEIFRTILDVASGRKQTWADRWGLHNDLCLFNPAP VT*" /label="garD CDS" gene 255596..257128 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /label="garD gene" promotor_-35 257140..257143 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 257158..257177 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 257170..257404 /Source="Nicolas_S_feature" /locus_tag="new_275603_275837" /HighExp="LoTm, Sw, BC, BI, B60, B36, T3.30H, T5.0H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.50265400000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S95" upshifts 257170 /Source="Nicolas_upshifts" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="upshifts" CDS 257405..258325 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_388134.1" /db_xref="EnsemblGenomes-Gn:BSU02520" /db_xref="EnsemblGenomes-Tr:CAB12046" /db_xref="GOA:P42242" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG11165" /db_xref="UniProtKB/Swiss-Prot:P42242" /translation="MTNLNEKQLITEIVGLARSQGLTVHSENAQLNETGMDFQVVFAK DDTGMPWVLRKPRRSDVVERASAEGITLAFLRANLTADVPDWRIHTPELIAYPMLKGT PAAGIDLEQKQYVWNMDHQPPSDDFVRTLADILAELHGTDQISAGQSGIEVIRPEDFR QMTADSMVDVKNKLGVSTTLWERWQKWVDDDAYWPGFSSLIHGDLHPPHILIDQNGRV TGLLDWTEAKVADPAKDFVLYQTIFGEKETARLLEYYDQAGGRIWAKMQEHISEMQAA YPVEIAKLALQTQQEEHINMALEALGVTSD*" /label="ycbJ CDS" gene 257405..258325 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /label="ycbJ gene" promotor_-35 258327..258334 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 258349..258368 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 258359 /Source="Nicolas_upshifts" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 258382..258629 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /product="T-box riboswitch specific of tryptophan tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 10706627, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 10706627, 12165569, 12547201; Product type n: RNA" /label="tboW RNA" gene 258382..258629 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /label="tboW gene" downshifts 258598 /Source="Nicolas_upshifts" /id="D98" /incds=0 /nref=225 /ntot=264 /MaxReadThrough="2.36361" /MaxDrop="6.52913" /score="36.5571172" /energy="-16.6" /TU="NA" /idTUdmin="U179" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS 258727..258888 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-TRAP regulator" /protein_id="NP_388135.1" /db_xref="EnsemblGenomes-Gn:BSU02530" /db_xref="EnsemblGenomes-Tr:CAB12047" /db_xref="GOA:O31466" /db_xref="InterPro:IPR031538" /db_xref="InterPro:IPR036410" /db_xref="PDB:2BX9" /db_xref="PDB:2KO8" /db_xref="PDB:2ZP8" /db_xref="PDB:2ZP9" /db_xref="SubtiList:BG12776" /db_xref="UniProtKB/Swiss-Prot:O31466" /translation="MVIATDDLEVACPKCERAGEIEGTPCPACSGKGVILTAQGYTLL DFIQKHLNK*" /label="rtpA CDS" gene 258727..258888 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /label="rtpA gene" promotor_no_box 258805..258905 /Source="Nicolas_upshift_promotors" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 258865 /Source="Nicolas_upshifts" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 258909..259847 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10706627, 15063849, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative tryptophan or indole exporter" /protein_id="NP_388136.1" /db_xref="EnsemblGenomes-Gn:BSU02540" /db_xref="EnsemblGenomes-Tr:CAB12048" /db_xref="GOA:P42243" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG11166" /db_xref="UniProtKB/Swiss-Prot:P42243" /translation="MRAEEQSKIREAAAGTIFLLIGTVCFASKSIWIKWAYQMGAEPD AVLLYRQLLAVPLFWLIFLIYRPPMPDGKKKGDLWKACGAGVFCFFLSPLLDFIGLNH VSAMVERILLMSYPLFVFGFTACRDRKMSSIQDLFAVLAVMFGLFLALGGWNAELFQA NMIGAVFILLSSAVYAGYLVLSGHLVHQIGGIRLNAYGMTAAGAAMMLYTGIKSAAGM NTPMAAYPLSMYGLFAVIAVVTTVIPFVLMLEGIKRIGAQRAAAISMAGPILTIFYGA LFLGERLGLIQVIGCGGVFFVITGMEYRKLKTGKKE*" /label="ycbK CDS" gene 258909..259847 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /label="ycbK gene" downshifts 258953 /Source="Nicolas_upshifts" /id="D99" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="3.05417" /MaxDrop="3.72787" /score="0.773303272" /energy="-9" /TU="NA" /idTUdmin="U181" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 259870..259889 /Source="Nicolas_upshift_promotors" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 259875..259943 /Source="Nicolas_S_feature" /locus_tag="new_278308_278376" /HighExp="C90, dia5, Lbtran, Lbexp, LBGexp, SMM, dia0, dia15, BMM, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S96" upshifts 259875 /Source="Nicolas_upshifts" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="upshifts" CDS 259944..260624 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YcbM]" /protein_id="NP_388137.2" /db_xref="EnsemblGenomes-Gn:BSU02550" /db_xref="EnsemblGenomes-Tr:CAB12049" /db_xref="GOA:P42244" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11167" /db_xref="UniProtKB/Swiss-Prot:P42244" /translation="MLVEDDHSISEMVDHYLTKEGFGIVHAFDGEEGIRLFQQGSYDL VLLDIMLPKLNGMDFLKIIREKSNIPVLMISAKDGDVDKALGLGFGADDYIAKPFSMI ELTARVKAAIRRATQYSAEEPAVNKVIRIHQLAIDIDNVSVLKNGEPLQLTSTEWQLL CLFASNPKKVFTKEQIYRSVWNEEYFDDQNIINVHMRRLREKIEDDPSSPQYIKTLWG IGYKLGEF*" /label="ycbL CDS" gene 259944..260624 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /label="ycbL gene" CDS 260626..261561 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YcbL]" /protein_id="NP_388138.2" /db_xref="EnsemblGenomes-Gn:BSU02560" /db_xref="EnsemblGenomes-Tr:CAB12050" /db_xref="GOA:P42245" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11168" /db_xref="UniProtKB/Swiss-Prot:P42245" /translation="MTVLWVAAVIALACLNVIQFIMKKKRDGNLAYTADQLSYMLSRD SAGQILLPTDDHALKDLLVNINLIVENRQQISAQFAKTEQSMKRMLTNMSHDLKTPLT VILGYIEAIQSDPNMPDEERERLLGKLRQKTNELIQMINSFFDLAKLESEDKEIPITK VHMNDICKRNILHYYDAVQSKGFQAAIDIPDTPVYAQANEEALDRILQNLLSNAIQYG AAGKLIGLTLSYDERNIAITVWDRGKGISETDQQRVFERLYTLEESRNKAFQGSGLGL TITKRLTEKMGGIISVQSKPYERTAFTITLKRMTY*" /label="ycbM CDS" gene 260626..261561 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /label="ycbM gene" CDS 261653..262576 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388139.2" /db_xref="EnsemblGenomes-Gn:BSU02570" /db_xref="EnsemblGenomes-Tr:CAB12051" /db_xref="GOA:P42246" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11169" /db_xref="UniProtKB/Swiss-Prot:P42246" /translation="MTYIVQTNGLTKTYQGKEVVSNVSMHIKKGEIYGFLGPNGAGKT TIMKMLTSLVKPTSGEIIILGNKFTHTSYEVLGNIGSMIEYPIFYENLTAEENLDLHC EYMGYHNKKAIQEVLDMVNLKQIDKKPVKTFSLGMKQRLGIARAILTKPDLLILDEPV NGLDPLGIKKIRQLFQVLSKEYGMTLLISSHLLGEIEQIADTIGVIRDGRLLEEVSME DVRGQNTEYIELVTPNQTRACFVLEKELQLTNFKILNEKTIRIYEAEASQAAISKALI LNDVDIESMNKKYTSLEDYFIKLINGNSISA*" /label="ycbN CDS" gene 261653..262576 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /label="ycbN gene" S_feature complement(262123..263307) /Source="Nicolas_S_feature" /locus_tag="new_280556_281740_c" /HighExp="Etha, Sw, Gly, B36, LoTm, B60, GM 150, Salt, C30, ferm" /AntisenseName="ycbO" /AntisenseCor="-0.38911425676406203" /AntisenseRegPval="-10.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S97" CDS 262595..263281 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven exporter" /protein_id="NP_388140.3" /db_xref="EnsemblGenomes-Gn:BSU02580" /db_xref="EnsemblGenomes-Tr:CAB12052" /db_xref="GOA:P42247" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11170" /db_xref="UniProtKB/Swiss-Prot:P42247" /translation="MNLIRIELRKMKMGWYIRGALIANVIIMGFMWLISYSEKADGGV SFQSTDEAFLIIGTFVRAVFIVFGAVLIVKLVISEYKNKTILVMFTYPISRKKLLTAK LMIAGGLTFITILLSNILIAAGFFWLNSICHFIPGELTSEIISQQAVKMAVFAFGAAG TSLVPIFFGMRRHSVPATIISSVVIVMLISSTSPGFSISSVVYIPLSLAAFGLFFSYM AIRNADKQDA*" /label="ycbO CDS" gene 262595..263281 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /label="ycbO gene" CDS complement(263242..263376) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513940.1" /translation="MARSIILKQEQTHNGKAGADSIGLLYILGAFVYASCLSAFLIAM *" /label="hypothetical protein CDS" gene complement(263242..263376) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /label="gene" downshifts 263276 /Source="Nicolas_upshifts" /id="D100" /incds=0 /nref=8 /ntot=120 /MaxReadThrough="1.13131" /MaxDrop="3.44039" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin="-1166" /isTUend="FALSE" /label="downshifts" CDS complement(263336..263722) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22582280; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative inner integral membrane protein" /protein_id="NP_388141.1" /db_xref="EnsemblGenomes-Gn:BSU02590" /db_xref="EnsemblGenomes-Tr:CAB12053" /db_xref="GOA:P42248" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG11171" /db_xref="UniProtKB/Swiss-Prot:P42248" /translation="MTHVKALAIKGIMTIIVLYLVLGLGFGFTFGDTLLMTIVLGVIS YLLGDLYVLPKWNNMIATLADFGLAFLVIWLMGMPLSMGMTGGEVALAALFGAIVMAI GEYCFHFYMMSKEIGKKHYLETRTDS*" /label="ycbP CDS" gene complement(263336..263722) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /label="ycbP gene" downshifts complement(263352) /Source="Nicolas_upshifts" /id="D101" /incds=0 /nref=148 /ntot=217 /MaxReadThrough="6.64196" /MaxDrop="7.40353" /score="13.8182557" /energy="-15.6" /TU="U183" /idTUdmin="U185" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(263748..263766) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(263767) /Source="Nicolas_upshifts" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(263780..263786) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(263800..264798) /Source="Nicolas_S_feature" /locus_tag="new_282233_283231_c" /HighExp="GM 150, T0.30H, C30, T1.30H, T1.0H, T-0.40H, T-3.40H, T2.0H, T2.30H, T-4.40H" /AntisenseName="cwlJ" /AntisenseCor="0.11463160303596701" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S98" downshifts complement(263843) /Source="Nicolas_upshifts" /id="D102" /incds=0 /nref=3 /ntot=10 /MaxReadThrough="5.23914" /MaxDrop="3.14515" /score="13.8182557" /energy="-15.6" /TU="U185,U187" /idTUdmin="U185" /TUdmin="-491" /isTUend="FALSE" /label="downshifts" promotor_-35 263979..263984 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 263998 /Source="Nicolas_upshifts" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 264000..264018 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(264012) /Source="Nicolas_upshifts" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(264014..264028) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(264034) /Source="Nicolas_upshifts" /id="D103" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="5.64474" /MaxDrop="3.76775" /score="13.8182557" /energy="-15.6" /TU="U187" /idTUdmin="U185" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" promotor_-35 complement(264036..264040) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 264036..264464 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore cortex cell wall hydrolase" /protein_id="NP_388142.2" /db_xref="EnsemblGenomes-Gn:BSU02600" /db_xref="EnsemblGenomes-Tr:CAB12054" /db_xref="GOA:P42249" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG11172" /db_xref="UniProtKB/Swiss-Prot:P42249" /translation="MAVVRATSADVDLMARLLRAEAEGEGKQGMLLVGNVGINRLRAN CSDFKGLRTIRQMIYQPHAFEAVTHGYFYQRARDSERALARRSINGERRWPAKFSLWY FRPQGDCPAQWYNQPFVARFKSHCFYQPTAETCENVYNTF*" /label="cwlJ CDS" gene 264036..264464 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /label="cwlJ gene" downshifts 264443 /Source="Nicolas_upshifts" /id="D104" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.30044" /MaxDrop="5.89045" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-35 264509..264515 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 264528..264547 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 264530 /Source="Nicolas_upshifts" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="upshifts" CDS 264570..265301 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388143.2" /db_xref="EnsemblGenomes-Gn:BSU02610" /db_xref="EnsemblGenomes-Tr:CAB12055" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR019303" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG11173" /db_xref="UniProtKB/Swiss-Prot:P42250" /translation="MATIDLQKKSVKIVLEKKQLTKVTARVGLVLDITGSMRPLYKNG TVQNVVERILAVADQFDDNGLLDVWVYDNEFSRLKPVSEKDFSGYVDREILNNDRLHK FGRNDEPPVMKDVLRKYVTEEPSSYPAFIVFINDGGCKKSIKPIIEASSDKPVFWQFV GIGNGNFDFLNKLDTLEGRVIDNTNFLHIEEIDRISDDELYDALLAEFPFWLKEAKEK GIVREQEPPAEKPKKKGFFSRLFSK*" /label="ycbR CDS" gene 264570..265301 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /label="ycbR gene" promotor_-10 complement(264772..264791) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(264798) /Source="Nicolas_upshifts" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(264805..264812) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 265219 /Source="Nicolas_upshifts" /id="D105" /incds=1 /nref=9 /ntot=148 /MaxReadThrough="1.70712" /MaxDrop="3.61288" /score="25.6672471" /energy="-14.1" /TU="NA" /idTUdmin="U186" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 265383..265559 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097673.1" /db_xref="EnsemblGenomes-Gn:BSU02619" /db_xref="EnsemblGenomes-Tr:CAX52543" /db_xref="UniProtKB/Swiss-Prot:C0H3T2" /translation="MGGLQTTGYAENASFSQLSACFSSRLVREDLFLMFSAYNQFTLL HSRLTMISYNGDDQ*" /label="yczK CDS" gene 265383..265559 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /label="yczK gene" promotor_-35 265511..265517 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 265524..265541 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 265535 /Source="Nicolas_upshifts" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="upshifts" CDS 265578..267329 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted phosphodiesterase (endo-hydrolysis at non-specific sites throughout the cell wall teichoic acid polymer)" /protein_id="NP_388144.2" /db_xref="EnsemblGenomes-Gn:BSU02620" /db_xref="EnsemblGenomes-Tr:CAB12056" /db_xref="GOA:P42251" /db_xref="InterPro:IPR008963" /db_xref="InterPro:IPR018946" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR032093" /db_xref="PDB:2YEQ" /db_xref="SubtiList:BG11174" /db_xref="UniProtKB/Swiss-Prot:P42251" /translation="MAYDSRFDEWVQKLKEESFQNNTFDRRKFIQGAGKIAGLSLGLT IAQSVGAFEVNAAPNFSSYPFTLGVASGDPLSDSVVLWTRLAPDPLNGGGMPKQAVPV KWEVAKDEHFRKIVRKGTEMAKPSLAHSVHVEADGLEPNKVYYYRFKTGHELSPVGKT KTLPAPGANVPQMTFAFASCQQYEHGYYTAYKHMAKEKLDLVFHLGDYIYEYGPNEYV SKTGNVRTHNSAEIITLQDYRNRHAQYRSDANLKAAHAAFPWVVTWDDHEVENNYANK IPEKGQSVEAFVLRRAAAYQAYYEHMPLRISSLPNGPDMQLYRHFTYGNLASFNVLDT RQYRDDQANNDGNKPPSDESRNPNRTLLGKEQEQWLFNNLGSSTAHWNVLAQQIFFAK WNFGTSASPIYSMDSWDGYPAQRERVINFIKSKNLNNVVVLTGDVHASWASNLHVDFE KTSSKIFGAEFVGTSITSGGNGADKRADTDQILKENPHIQFFNDYRGYVRCTVTPHQW KADYRVMPFVTEPGAAISTRASFVYQKDQTGLRKVSSTTIQGGVKQSDEVEEDRFFSH NKAHEKQMIKKRAKITN*" /label="phoD CDS" gene 265578..267329 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /label="phoD gene" promotor_-10 complement(265632..265647) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(265638) /Source="Nicolas_upshifts" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(265660..265669) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 267342..267554 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867413, 15554971, 16678787, 19049517, 21479530, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867413, 15554971, 16678787, 19049517, 21479530, 27984091; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388145.2" /db_xref="EnsemblGenomes-Gn:BSU02630" /db_xref="EnsemblGenomes-Tr:CAB12057" /db_xref="GOA:O31467" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR003998" /db_xref="InterPro:IPR006312" /db_xref="PDB:2L16" /db_xref="SubtiList:BG12777" /db_xref="UniProtKB/Swiss-Prot:O31467" /translation="MFSNIGIPGLILIFVIALIIFGPSKLPEIGRAAGRTLLEFKSAT KSLVSGDEKEEKSAELTAVKQDKNAG*" /label="tatAD CDS" gene 267342..267554 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /label="tatAD gene" S_feature 267555..267614 /Source="Nicolas_S_feature" /locus_tag="new_285988_286047" /HighExp="LPhT, BI, Paraq, C90, H2O2, M40t90, C30, M0t90, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0569" /TUlongSig="NA" /TUlongPSig="NA" /label="S99" CDS 267615..268343 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16698798, 19049517, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16698798, 19049517, 27984091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388146.2" /db_xref="EnsemblGenomes-Gn:BSU02640" /db_xref="EnsemblGenomes-Tr:CAB12058" /db_xref="GOA:P42252" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG11175" /db_xref="UniProtKB/Swiss-Prot:P42252" /translation="MDKKETHLIGHLEELRRRIIVTLAAFFLFLITAFLFVQDIYDWL IRDLDGKLAVLGPSEILWVYMMLSGICAIAASIPVAAYQLWRFVAPALTKTERKVTLM YIPGLFALFLAGISFGYFVLFPIVLSFLTHLSSGHFETMFTADRYFRFMVNLSLPFGF LFEMPLVVMFLTRLGILNPYRLAKARKLSYFLLIVVSILITPPDFISDFLVMIPLLVL FEVSVTLSAFVYKKRMREETAAAA*" /label="tatCD CDS" gene 267615..268343 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /label="tatCD gene" downshifts complement(267623) /Source="Nicolas_upshifts" /id="D106" /incds=0 /nref=4 /ntot=146 /MaxReadThrough="1.2763" /MaxDrop="3.13944" /score="-9.00478071" /energy="-8.5" /TU="NA" /idTUdmin="U190" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(268340..268987) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /EC_number="3.4.19.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1362573, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1362573, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrrolidone-carboxylate (pyroglutamate) peptidase" /protein_id="NP_388147.1" /db_xref="EnsemblGenomes-Gn:BSU02650" /db_xref="EnsemblGenomes-Tr:CAB12059" /db_xref="GOA:P28618" /db_xref="InterPro:IPR000816" /db_xref="InterPro:IPR016125" /db_xref="InterPro:IPR029762" /db_xref="InterPro:IPR033693" /db_xref="InterPro:IPR033694" /db_xref="InterPro:IPR036440" /db_xref="SubtiList:BG10873" /db_xref="UniProtKB/Swiss-Prot:P28618" /translation="MRKKVLITGFDPFDKETVNPSWEAAKRLNGFETEEAIITAEQIP TVFRSALDTLRQAIQKHQPDIVICVGQAGGRMQITPERVAINLADARIPDNEGHQPID EEISPDGPAAYWTRLPVKRMTAKMKEHGIPAAVSYTAGTFVCNYLFYGLMDHISRTSP HIRGGFIHIPYIPQQTIDKTAPSLSLDTIVRALRIAAVTAAQYDEDVKSPGGTLH*" /label="pcp CDS" gene complement(268340..268987) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /label="pcp gene" promotor_-10 complement(269002..269021) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 269015..269021 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(269016) /Source="Nicolas_upshifts" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(269036..269040) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 269036..269055 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 269038 /Source="Nicolas_upshifts" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="upshifts" CDS 269066..270178 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase (PLP-dependent)" /protein_id="NP_388148.2" /db_xref="EnsemblGenomes-Gn:BSU02660" /db_xref="EnsemblGenomes-Tr:CAB12060" /db_xref="GOA:P42253" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG11176" /db_xref="UniProtKB/Swiss-Prot:P42253" /translation="MEHLPEQYRQLFPTLQTHTMLASCSQSALAEPVSRAIQDYYDSL LYKGTNWKEAIEKTEFARNEFAKLIGAEPDEVAIVPSVSDALVSVASSLTAFGKKHVV YTDMDFPAVPHVWQAHSDYTVSVIPSIDGVLPLEQYETHISDETVLTCVPHVHYRDGY VQDIKAIAEISQRKGSLLFVDAYQSAGHIPIDVKEWGVDMLAAGTRKYLLGIPGVAFL YVRKELADALKPKASAWFGRESGFDGAYAKVARRFQTGTPAFISVYAAAAALSLLNHI GVSHIRDHVKTICADAVQYAAEKGLQLAAAQGGIQPGMVAIRDERASETAGLLKKKKV ICAPRENVIRLAPHFYNTKEEMRHAIDEIAAKTIHK*" /label="ycbU CDS" gene 269066..270178 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /label="ycbU gene" upshifts complement(269412) /Source="Nicolas_upshifts" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(269415..269434) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(269450..269454) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 270172 /Source="Nicolas_upshifts" /id="D107" /incds=0 /nref=45 /ntot=226 /MaxReadThrough="1.10091" /MaxDrop="4.52742" /score="6.75687898" /energy="-14" /TU="NA" /idTUdmin="U191" /TUdmin=814 /isTUend="FALSE" /label="downshifts" CDS complement(270220..271659) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 17483215; Product type t: transporter" /codon_start=1 /transl_table=11 /product="flavonoid efflux transporter; drug-export protein" /protein_id="NP_388149.1" /db_xref="EnsemblGenomes-Gn:BSU02670" /db_xref="EnsemblGenomes-Tr:CAB12061" /db_xref="GOA:O35018" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12613" /db_xref="UniProtKB/Swiss-Prot:O35018" /translation="MILETTAKASQQYKVMPIMISLLLAGFIGMFSETALNIALTDLM KELNITAATVQWLTTGYLLVLGILVPVSGLLLQWFTTRQLFTVSLIFSILGTFIAALA PSFSFLLAARIVQALGTGLLLPLMFNTILVIFPPHKRGAAMGTIGLVIMFAPAIGPTF SGLVLEHLNWHWIFWISLPFLVLALVFGIAYMQNVSETTKPKIDVLSIILSTIGFGGI VFGFSNAGEGSGGWSSPTVIVSLIVGVVGLILFSIRQLTMKQPMMNLRAFKYPMFILG VIMVFICMMVILSSMLLLPMYLQGGLVLTAFASGLVLLPGGILNGFMSPVTGRLFDKY GPKWLVIPGFVIVTVVLWFFSNVTTTSTAVLIIILHTCLMIGISMIMMPAQTNGLNQL PREFYPDGTAIMNTLQQMAGAIGTAVAVSIMAAGQHDYMSTVKNPADPAVIPQALTAG VQHAFVFAMIVAIIGLIGAFFMKRVKVDH*" /label="lmrB CDS" gene complement(270220..271659) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /label="lmrB gene" downshifts complement(270227) /Source="Nicolas_upshifts" /id="D108" /incds=0 /nref=162 /ntot=245 /MaxReadThrough="0.65833" /MaxDrop="6.75228" /score="18.3484535" /energy="-14" /TU="U193" /idTUdmin="U193" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(271699..272265) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12718394, 15317768, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12718394, 15317768, 17483215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of lmrAB and yxaGH operons (flavonoid and antibiotic resistance)" /protein_id="NP_388150.1" /db_xref="EnsemblGenomes-Gn:BSU02680" /db_xref="EnsemblGenomes-Tr:CAB12062" /db_xref="GOA:O34619" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12612" /db_xref="UniProtKB/Swiss-Prot:O34619" /translation="MSYGDSREKILSAATRLFQLQGYYGTGLNQIIKESGAPKGSLYY HFPGGKEQLAIEAVNEMKEYIRQKIADCMEACTDPAEGIQAFLKELSCQFSCTEDIEG LPVGLLAAETSLKSEPLREACHEAYKEWASVYEEKLRQTGCSESRAKEASTVVNAMIE GGILLSLTAKNSTPLLHISSCIPDLLKR*" /label="lmrA CDS" gene complement(271699..272265) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /label="lmrA gene" promotor_-10 complement(272303..272322) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(272317) /Source="Nicolas_upshifts" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(272337..272344) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 272419..272425 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 272441..272458 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 272447 /Source="Nicolas_upshifts" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="upshifts" CDS 272482..273609 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /EC_number="3.5.1.1" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914346, 17686772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346, 17686772; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-asparaginase 2 (putative lipoprotein)" /protein_id="NP_388151.1" /db_xref="EnsemblGenomes-Gn:BSU02690" /db_xref="EnsemblGenomes-Tr:CAB12063" /db_xref="GOA:O34482" /db_xref="InterPro:IPR004550" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG12755" /db_xref="UniProtKB/Swiss-Prot:O34482" /translation="MKKQRMLVLFTALLFVFTGCSHSPETKESPKEKAQTQKVSSASA SEKKDLPNIRILATGGTIAGADQSKTSTTEYKAGVVGVESLIEAVPEMKDIANVSGEQ IVNVGSTNIDNKILLKLAKRINHLLASDDVDGIVVTHGTDTLEETAYFLNLTVKSDKP VVIVGSMRPSTAISADGPSNLYNAVKVAGAPEAKGKGTLVVLNDRIASARYVTKTNTT TTDTFKSEEMGFVGTIADDIYFNNEITRKHTKDTDFSVSNLDELPQVDIIYGYQNDGS YLFDAAVKAGAKGIVFAGSGNGSLSDAAEKGADSAVKKGVTVVRSTRTGNGVVTPNQD YAEKDLLASNSLNPQKARMLLMLALTKTNDPQKIQAYFNEY*" /label="ansZ CDS" gene 272482..273609 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /label="ansZ gene" downshifts 273582 /Source="Nicolas_upshifts" /id="D109" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="1.70459" /MaxDrop="4.27333" /score="23.2201078" /energy="-7.6" /TU="NA" /idTUdmin="U194" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 273706..273712 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 273726..273745 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 273726 /Source="Nicolas_upshifts" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="upshifts" CDS 273772..274410 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8396026, 15812018, 18053819, 11029590, 24827611, 28963005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8396026, 15812018, 18053819, 11029590, 24827611, 28963005; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="secreted alkaliphilic lipase" /protein_id="NP_388152.1" /db_xref="EnsemblGenomes-Gn:BSU02700" /db_xref="EnsemblGenomes-Tr:CAB12064" /db_xref="GOA:P37957" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="PDB:1I6W" /db_xref="PDB:1ISP" /db_xref="PDB:1R4Z" /db_xref="PDB:1R50" /db_xref="PDB:1T2N" /db_xref="PDB:1T4M" /db_xref="PDB:2QXT" /db_xref="PDB:2QXU" /db_xref="PDB:3D2A" /db_xref="PDB:3D2B" /db_xref="PDB:3D2C" /db_xref="PDB:3QMM" /db_xref="PDB:3QZU" /db_xref="PDB:5CRI" /db_xref="PDB:5CT4" /db_xref="PDB:5CT5" /db_xref="PDB:5CT6" /db_xref="PDB:5CT8" /db_xref="PDB:5CT9" /db_xref="PDB:5CTA" /db_xref="PDB:5CUR" /db_xref="SubtiList:BG10679" /db_xref="UniProtKB/Swiss-Prot:P37957" /translation="MKFVKRRIIALVTILMLSVTSLFALQPSAKAAEHNPVVMVHGIG GASFNFAGIKSYLVSQGWSRDKLYAVDFWDKTGTNYNNGPVLSRFVQKVLDETGAKKV DIVAHSMGGANTLYYIKNLDGGNKVANVVTLGGANRLTTGKALPGTDPNQKILYTSIY SSADMIVMNYLSRLDGARNVQIHGVGHIGLLYSSQVNSLIKEGLNGGGQNTN*" /label="estA CDS" gene 273772..274410 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /label="estA gene" downshifts 274396 /Source="Nicolas_upshifts" /id="D110" /incds=0 /nref=15 /ntot=117 /MaxReadThrough="4.54554" /MaxDrop="4.10395" /score="23.2201078" /energy="-7.6" /TU="U195" /idTUdmin="U194" /TUdmin=814 /isTUend="FALSE" /label="downshifts" S_feature 274441..275031 /Source="Nicolas_S_feature" /locus_tag="new_292874_293464" /HighExp="M9-tran, GM 150, LoTm, MG 150, GM 120, aero, T-1.40H, M/G, S2, GM 90" /AntisenseName="yczC" /AntisenseCor="3.5651747957185502E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S100" CDS complement(274448..274831) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_388153.1" /db_xref="EnsemblGenomes-Gn:BSU02710" /db_xref="EnsemblGenomes-Tr:CAB12065" /db_xref="GOA:O31469" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG12778" /db_xref="UniProtKB/Swiss-Prot:O31469" /translation="MELAGFMLRACALLLDVIIAAAVILAAGFTFGDGSAGVIIVAIL MLIVYPLLMPLTNWKGTLGKKIIGLQIVRDETYKKISFPQAIVRYLIAWVHVFSRLIY LTAAFTKKKQTVHDMAAKTIVLKAE*" /label="yczC CDS" gene complement(274448..274831) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /label="yczC gene" downshifts complement(274472) /Source="Nicolas_upshifts" /id="D111" /incds=0 /nref=4 /ntot=94 /MaxReadThrough="0.85389" /MaxDrop="2.7858" /score="15.0330092" /energy="-12.1" /TU="NA" /idTUdmin="U196" /TUdmin=0 /isTUend="TRUE" /label="downshifts" Polymorphism join(274645,274647) /Source="geneious" /ID="SNP_BsDelta6_293079_293079" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=186 /Change="C -> T" /Codon_Change="CTG -> CTA" /Coverage=154 /locus_tag="BSU_02710" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" promotor_-10 complement(274861..274880) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(274868) /Source="Nicolas_upshifts" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(274894..274901) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 275003..275006 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 275022..275041 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 275033 /Source="Nicolas_upshifts" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="upshifts" CDS 275066..276142 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388154.1" /db_xref="EnsemblGenomes-Gn:BSU02720" /db_xref="EnsemblGenomes-Tr:CAB12066" /db_xref="GOA:O34478" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR007889" /db_xref="InterPro:IPR036915" /db_xref="SubtiList:BG12756" /db_xref="UniProtKB/Swiss-Prot:O34478" /translation="MGKVKRNAPCPCGSGKKYKKCCGSKVVDFPAELAAKEAKQIQED LVEYAFTVHRESISGFINQHDFLSAMDRQTKDISVFNLGIWGIFFHPLAGEKTIFEEY LQKKGDSITRPKTREIVESWQSMTPALLLLKDLKEGIIHFEDVITAKQFEVEMDASNQ DLPPVGSLILGYPIHEAEKAEFFMQFTIFPVKRTEALISKVKKYADAAVKDGKTPEDF MKQEFNNVLFALLAEKDEEPQAEKAEVSTVEWANDLEKETAAAIEEGMSGEEYPTELI PAVIDIWKTFCEKKSPVIRKPEAFAAAVEYYVNAISLNGASVSQAKLAKKYGVSASTI SSRYKEIESTLQDEADRFAQALSS*" /label="yccF CDS" gene 275066..276142 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /label="yccF gene" downshifts 276136 /Source="Nicolas_upshifts" /id="D112" /incds=0 /nref=60 /ntot=248 /MaxReadThrough="1.55048" /MaxDrop="5.18328" /score="33.0000484" /energy="-12.9" /TU="NA" /idTUdmin="U197" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(276182..277138) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [NatR]" /protein_id="NP_388155.1" /db_xref="EnsemblGenomes-Gn:BSU02730" /db_xref="EnsemblGenomes-Tr:CAB12067" /db_xref="GOA:P70954" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR032834" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11997" /db_xref="UniProtKB/Swiss-Prot:P70954" /translation="MITLFQCLYLILFSFICYQGAAAFSHSTAASWLAAALGAAAAGL YIWNTKRVWKHCSSGLCAWIAVIQVMSVGVVLIGTDIMPVLCVIAIFAGCEGLRIGQS ALQARLSDQIDKLTQAEQHANQMLIDVRSRNHDTMKHITAIKSAQPKADTQAYIQNWA DQYSQYDRFLKGENAYVAGVLYDFLEKARASNVSVSLHMHTPLSSLPFSPADQVSLVG NILENALDSAAEAREKAEIKLETSLRSGLYVLTCENSTPGMDPKVLDTIYQSFGRSTK NGAHEGMGTYIIQKLVKGAFGRLDFTYRHPIFRLEIKIPFQK*" /label="natK CDS" gene complement(276182..277138) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /label="natK gene" downshifts complement(276210) /Source="Nicolas_upshifts" /id="D113" /incds=0 /nref=1 /ntot=129 /MaxReadThrough="0.86926" /MaxDrop="2.67125" /score="14.02819" /energy="-12.9" /TU="NA" /idTUdmin="U198" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(277151..277852) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [NatK]" /protein_id="NP_388156.1" /db_xref="EnsemblGenomes-Gn:BSU02740" /db_xref="EnsemblGenomes-Tr:CAB12068" /db_xref="GOA:P70955" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11998" /db_xref="UniProtKB/Swiss-Prot:P70955" /translation="MVKVGLVDDYRVDLEKLEAIVSRMQDVEIVFSTDSAKEAYRRVK NGDIDLLLADIEMPHMSGYELADLIKSHSLDVDVIFVTGHGGYAVHAFDLNVHDYIMK PYYADRLAASFDRYLKKKTETSLNGRILIKQKSEMHVLQKKDIIFAERTGRSTTIVTT AEEVQTYQTLNDIKGDLPEKDFLRSHRSFIINIHYIKHFSAYTKHSFTVSFEGTSKKA MITKQQLDYFQNYYF*" /label="natR CDS" gene complement(277151..277852) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /label="natR gene" promotor_-10 complement(277876..277895) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(277882) /Source="Nicolas_upshifts" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(277911..277914) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 277932..277935 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 277951..277970 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 277961 /Source="Nicolas_upshifts" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="upshifts" CDS 277996..278736 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10356997, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388157.1" /db_xref="EnsemblGenomes-Gn:BSU02750" /db_xref="EnsemblGenomes-Tr:CAB12069" /db_xref="GOA:P46903" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11338" /db_xref="UniProtKB/Swiss-Prot:P46903" /translation="MITLTDCSRRFQDKKKVVKAVRDVSLTIEKGEVVGILGENGAGK TTMLRMIASLLEPSQGVITVDGFDTVKQPAEVKQRIGVLFGGETGLYDRMTAKENLQY FGRLYGLNRHEIKARIEDLSKRFGMRDYMNRRVGGFSKGMRQKVAIARALIHDPDIIL FDEPTTGLDITSSNIFREFIQQLKREQKTILFSSHIMEEVQALCDSVIMIHSGEVIYR GALESLYESERSEDLNYIFMSKLVRGIS*" /label="natA CDS" gene 277996..278736 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /label="natA gene" CDS 278737..279897 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10356997, 15849754, 16850406, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 15849754, 16850406, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (permease)" /protein_id="NP_388158.1" /db_xref="EnsemblGenomes-Gn:BSU02760" /db_xref="EnsemblGenomes-Tr:CAB12070" /db_xref="GOA:P46904" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11339" /db_xref="UniProtKB/Swiss-Prot:P46904" /translation="MLSHIYKKEMIDALRDRKTILLTILVPMIMMLGLVFFYESMLSD KGEQYTLAVGHSLPPALESKLNEIDEISVKTFAKPEEAVDEGKADAYLNVPKEFDSYV NSMTPFKVDVYGNSIDQGSSNAMQLVQSALDQYKNEIVQQRLTNKHIDQSVIQPFTIQ QKEADEEKGTSAIMLSAILPMLILTSIVSGAMPIALDIMAGEKDRKSIEALLLTPVSR NKVLVGKWLAVSTFGVASGVFALVFLILSTVLFTENLKTAFQLGDHMWSVIGASALII VLSALLISAMELFISIMSSSVKEAQSYMSLVVFLPVFPMFFIFSKAPNQFDLSYFLIP FLNLHALFKQLLFGMVDPATILSTSGTIAVLIAIFFLLARACFLKDKWVLPK*" /label="natB CDS" gene 278737..279897 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /label="natB gene" promotor_-35 279948..279956 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 279968..279986 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 279968 /Source="Nicolas_upshifts" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="upshifts" CDS 280033..280965 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /EC_number="1.-.-.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322186, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ion channel associated aldo-keto reductase" /protein_id="NP_388159.1" /db_xref="EnsemblGenomes-Gn:BSU02770" /db_xref="EnsemblGenomes-Tr:CAB12071" /db_xref="GOA:P46905" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11340" /db_xref="UniProtKB/Swiss-Prot:P46905" /translation="MDQTRTLGKTKLKVKRIGFGANAVGGHNLFPNLNDETGKDLVRT ALDGGVNFIDTAFIYGLGRSEELIGEVVQERGVRNELIIATKGAHKEVDGSIELDNSR EFLRSEVEKSLKRLKTDYIDLYYVHFPDGKTPLAEVAGTLKELKDEGKIKAIGASNLD YQQLQDFNADGYLEVFQAEYSLIQRDAEKELLPYCEKQGISFIPYFPLASGLLTGKFT QDTVFDDFRKDKPQFQGETFIHNLKKVDKLKAVAEEKQADTAHVALAWLLTRPAIDAI IPGAKRPEQLQDNLKTLNIELTEDEVNFISDIFK*" /label="yccK CDS" gene 280033..280965 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /label="yccK gene" CDS complement(281005..282069) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 22496484; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in swarming behaviour" /protein_id="NP_388160.1" /db_xref="EnsemblGenomes-Gn:BSU02780" /db_xref="EnsemblGenomes-Tr:CAB12072" /db_xref="GOA:O34538" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="InterPro:IPR031343" /db_xref="PDB:4R4G" /db_xref="SubtiList:BG12757" /db_xref="UniProtKB/Swiss-Prot:O34538" /translation="MFQKKTYAVFLILLLMMFTAACSGSKTSAEKKESETEKSSDIAQ VKIKDVSYTLPSKYDKSTSDDQLVLKVNVAVKNTGKDPLNVDSMDFTLYQGDTKMSDT DPEDYSEKLQGSTINADKSVEGNLFFVVDKGKQYELNYTPESYGDKKPKSVTFKIDGK DKKILATADKLQDSAKALSAYVDVLLFGKDNADFEKITGANKNEIVNDFNESAKDGYL SASGLSSTYADSKALDNIVNGIKEGLSKNSSIQAKTTSISKDEAIVEATVKPVDASSL SDRIEDKVKDYYSKNSSASYEEAVKYALQVYPEEFKKLGPASSEKTVEVKMKKNDIDQ WQLDMDDYRAAELVEAFIKE*" /label="ycdA CDS" gene complement(281005..282069) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /label="ycdA gene" downshifts complement(281006) /Source="Nicolas_upshifts" /id="D114" /incds=0 /nref=198 /ntot=222 /MaxReadThrough="0.57029" /MaxDrop="8.85093" /score="27.0612397" /energy="-13.7" /TU="NA" /idTUdmin="U201" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(282070..282260) /Source="Nicolas_S_feature" /locus_tag="new_300503_300693_c" /HighExp="S5, S4, MG 45, MG 15, MG-0.2, MG 25, MG-0.1, MG 10, S3, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S101" CDS complement(282092..282223) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513941.1" /translation="MTKEGGVSRKSGENREKRTDFFGYMMLIHSKRSISQRQKTPLS* " /label="hypothetical protein CDS" gene complement(282092..282223) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /label="gene" promotor_-10 complement(282245..282264) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(282265) /Source="Nicolas_upshifts" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(282279..282286) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 282397..283815 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388161.1" /db_xref="EnsemblGenomes-Gn:BSU02790" /db_xref="EnsemblGenomes-Tr:CAB12073" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12758" /db_xref="UniProtKB/Swiss-Prot:O34621" /translation="MKGAAFVKKEGLKQKALEIGRVPTHLKLEIEDYGGDDKRAHFCW ADPQDENTGIIVELGPDGELESLSRDIEPESGERLSEEKLEDIMRQFVETHHPGALSA FVREENDRAYGDKVRFSYVQMEAGLPLPMSGFMADVSLSGEIVYFRYYGEAGSIIKPK RVADVEEALAFIKKDVEFDLLFEVLHRSVYKNGDDQPHLVYEPEGRAITVPADLVQEE QAVDDDDDYREPESFPLPLFEGIREKADPDSMIGIENGFVKEREADLGDGRIGIVWRN PDDPVYQPADKSMDSWFKGRTHQVLKTIYNKETGKLEGVMSFMEKKGPLTVTLAECEK IALRFLFALFPNADQYFRIRYDEKDEEENAVAGFTFEAHCHGVPLRFGQIRICVSRQT GYITVYMGPDIDPNKLATIDPVPAISVEQAKSIFWQHFKVELGWEREYGDDEEHSYRL VYKPVYPHFIDAHTGEPVFSIW*" /label="ycdB CDS" gene 282397..283815 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /label="ycdB gene" promotor_-10 complement(283858..283876) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(283866) /Source="Nicolas_upshifts" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(283890..283897) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 283922..284001 /Source="Nicolas_S_feature" /locus_tag="new_302355_302434" /HighExp="ferm, M40t45, M0t45, Lbstat, S0, nit, LBGtran, Lbtran, G135, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S102" upshifts 283922 /Source="Nicolas_upshifts" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="upshifts" promotor_-35 283924..283930 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-35" promotor_-10 283945..283962 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-10" CDS 284002..285363 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388162.1" /db_xref="EnsemblGenomes-Gn:BSU02800" /db_xref="EnsemblGenomes-Tr:CAB12074" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12759" /db_xref="UniProtKB/Swiss-Prot:O34772" /translation="MVNKQLKKKAQEIGNVPTHYELEIEDYDQKQKKYGQAYFIWKDP KDPEKHITVELRNDGALLTFSTTVHSETDKKLPDAELKLTALQFAAANHPGTFMNFHF QGKEERGQHIRFVYTKMELGLPIPNSGFLIDMTRSGQIVHFLYYGEGHKAEVPTEFVA KEKVVSHYLNTMSFELMYDVIDGEQEPRLVYEPILPGYSYPADVDEIVPDQHIADERI ENTAPLPPLQNKEEVDIFALLGFTSDMQKVSERDFGEQIGSTWRRGAAPERKDLSIGS YFETRNKNTIKMKTDKRTGKLKAALSFMDWRNNLQCSTEECQEIALQFLYALYPRAAE FFRVNPVRIDERGRVRNHFSVWYKGVPLRFGAARIIVNPETGLIDAFMAPDIEPEQLE AINHRPDVSAEEAKEAFLAAFDVKLEWQPDFTAGSDQHCKLVYKPVYPSYIDAHIRKK KRL*" /label="ycdC CDS" gene 284002..285363 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /label="ycdC gene" S_feature 285364..285944 /Source="Nicolas_S_feature" /locus_tag="new_303797_304377" /HighExp="ferm, M0t45, G135, G180, H2O2, M40t45, G150, Paraq, S0, nit" /AntisenseName="cwlK" /AntisenseCor="0.27553388443794402" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S103" CDS complement(285371..285874) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17588176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17588176; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="murein L,D:-endopeptidase" /protein_id="NP_388163.1" /db_xref="EnsemblGenomes-Gn:BSU02810" /db_xref="EnsemblGenomes-Tr:CAB12075" /db_xref="GOA:O34360" /db_xref="InterPro:IPR009045" /db_xref="SubtiList:BG12760" /db_xref="UniProtKB/Swiss-Prot:O34360" /translation="MNLPAKTFVILCILFLLDLCFSYIRHEWHSQNALQDMPVPSDLH PIVKQNADALKAAAANKGIDVVITEGFRSFKEQDELYKQGRTKKGNIVTYARGGESYH NYGLAIDFALQKKDGSIIWDMEYDGNQNGKSDWLEVVEIAKTLGFEWGGDWKRFKDYP HLEMIPN*" /label="cwlK CDS" gene complement(285371..285874) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /label="cwlK gene" S_feature complement(285875..285956) /Source="Nicolas_S_feature" /locus_tag="new_304308_304389_c" /HighExp="Cold, T0.30H, LBGstat, C30, T-0.40H, T1.0H, T1.30H, H2O2, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S104" upshifts 285946 /Source="Nicolas_upshifts" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="upshifts" promotor_-10 complement(285948..285967) /Source="Nicolas_upshift_promotors" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 285949..285968 /Source="Nicolas_upshift_promotors" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(285957) /Source="Nicolas_upshifts" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="upshifts" CDS 285997..287118 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16816200; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388164.1" /db_xref="EnsemblGenomes-Gn:BSU02820" /db_xref="EnsemblGenomes-Tr:CAB12076" /db_xref="GOA:O34327" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:4GYO" /db_xref="SubtiList:BG12663" /db_xref="UniProtKB/Swiss-Prot:O34327" /translation="MRAKIPSEEVAVKLNEWYKLIRAFEADQAEALKQEIEYDLEDME ENQDLLLYFSLMEFRHRIMLDKLMPVKDSDTKPPFSDMLNEIESNQQKLTGLLEYYFY YFRGMYEFKQKNFILAIDHYKHAEEKLEYVEDEIEKAEFLFKVAEVYYHIKQTYFSMN YASQALDIYTKYELYGRRRVQCEFIIAGNLTDVYHHEKALTHLCSALEHARQLEEAYM IAAAYYNVGHCKYSLGDYKEAEGYFKTAAAIFEEHNFQQAVQAVFSLTHIYCKEGKYD KAVEAYDRGIKSAAEWEDDMYLTKFRLIHELYLGSGDLNVLTECFDLLESRQLLADAE DLLHDTAERFNQLEHYESAAFFYRRLMNIKKKLAEQRFQ*" /label="rapJ CDS" gene 285997..287118 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /label="rapJ gene" downshifts 287112 /Source="Nicolas_upshifts" /id="D115" /incds=0 /nref=88 /ntot=228 /MaxReadThrough="3.8438" /MaxDrop="5.06867" /score="32.2653577" /energy="-13.2" /TU="U204" /idTUdmin="U204" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 287159..287165 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 287180..287198 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 287183 /Source="Nicolas_upshifts" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" CDS 287225..288001 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388165.1" /db_xref="EnsemblGenomes-Gn:BSU02830" /db_xref="EnsemblGenomes-Tr:CAB12077" /db_xref="GOA:P80869" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12761" /db_xref="UniProtKB/Swiss-Prot:P80869" /translation="MYKDLTGKTAIVTGSSKGIGKAIAERFGKEKMNVVVNYHSDPSG ADETLEIIKQNGGKAVSVEADVSKEEGIQALLDTALEHFGTLDVMVNNSGFNGVEAMP HEMSLEDWQRVIDVNVTGTFLGAKAALNHMMKNNIKGNVLNISSVHQQIPRPVNVQYS TSKGGIKMMTETLALNYADKGIRVNAIAPGTIATESNVDTKKEESRQKQLKKIPMKAF GKPEEVAAAAAWLVSEEASYVTGATLFVDGGMTLYPSQLE*" /label="ycdF CDS" gene 287225..288001 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /label="ycdF gene" downshifts complement(287232) /Source="Nicolas_upshifts" /id="D116" /incds=0 /nref=10 /ntot=23 /MaxReadThrough="0.31912" /MaxDrop="4.8095" /score="0.506500496" /energy="-5.8" /TU="NA" /idTUdmin="U205" /TUdmin="-1914" /isTUend="FALSE" /label="downshifts" CDS 288026..289711 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-carbohydrate hydrolase" /protein_id="NP_388166.1" /db_xref="EnsemblGenomes-Gn:BSU02840" /db_xref="EnsemblGenomes-Tr:CAB12078" /db_xref="GOA:O34364" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12762" /db_xref="UniProtKB/Swiss-Prot:O34364" /translation="MKTDWWKDAVVYQIYPRSFQDSNGDGIGDLRGIISRLDYIKELG ADVIWICPIYPSPNVDYGYDVTNHKAIMDSYGTMDDFHELLDQVHQRGLKLVMDFVLN HTSVEHPWFKEAELDKNSKYRSYYYWRPGTKNGPPTDWLSNYGCPVWQYEEHTGEYYL HMNAVKQADLNWENPEVRQAVYDMMKFWLDKGVDGLRIDQLHLISKKEYLPSYEDYIN QQAEPKPFQPNGERIHDYLKEITDEVFSHYDVMSVGEVGSVTPEEGLKYTGTDKHELN MIFHFQHMELDQQPGKEHWDLKPLELSDLKSVLTKWQKKLEHQGWNTLFWCNHDQPRI VSRFGDDGEYRKASAKMLAAVIYFMKGTPYIYQGEEIGMTNAPFTRIEDYKDIQTINM YHKRVFEKGYDPNDVMRSILAKSRDHARTPMQWNSGKNAGFTDGTPWLKVNPNFTAIN VEEAQGDPDSVLNYYKKLISLRKQYADLMKGSFDLLLPDDPQLFVYMRENSKQQLLSV NNFSKEQAVFQWPKNCGKAQASLLLSNYNNDDLDDEMVFRPYESRVYLLDKTN*" /label="ycdG CDS" gene 288026..289711 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /label="ycdG gene" promotor_no_box 288966..289066 /Source="Nicolas_upshift_promotors" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 289026 /Source="Nicolas_upshifts" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 289092 /Source="Nicolas_upshifts" /id="D117" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.77365" /MaxDrop="2.18547" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=1914 /isTUend="FALSE" /label="downshifts" downshifts 289708 /Source="Nicolas_upshifts" /id="D118" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="5.8252" /MaxDrop="5.18702" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=2530 /isTUend="FALSE" /label="downshifts" promotor_-35 289802..289809 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 289825..289844 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 289831 /Source="Nicolas_upshifts" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" CDS 289899..290858 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9379902, 12426338, 14730579, 21813502; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="Zn(II)-binding lipoprotein" /protein_id="NP_388167.1" /db_xref="EnsemblGenomes-Gn:BSU02850" /db_xref="EnsemblGenomes-Tr:CAB12079" /db_xref="GOA:O34966" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="PDB:2O1E" /db_xref="SubtiList:BG12763" /db_xref="UniProtKB/Swiss-Prot:O34966" /translation="MFKKWSGLFVIAACFLLVAACGNSSTKGSADSKGDKLHVVTTFY PMYEFTKQIVKDKGDVDLLIPSSVEPHDWEPTPKDIANIQDADLFVYNSEYMETWVPS AEKSMGQGHAVFVNASKGIDLMEGSEEEHEEHDHGEHEHSHAMDPHVWLSPVLAQKEV KNITAQIVKQDPDNKEYYEKNSKEYIAKLQDLDKLYRTTAKKAEKKEFITQHTAFGYL AKEYGLKQVPIAGLSPDQEPSAASLAKLKTYAKEHNVKVIYFEEIASSKVADTLASEI GAKTEVLNTLEGLSKEEQDKGLGYIDIMKQNLDALKDSLLVKS*" /label="znuA CDS" gene 289899..290858 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /label="znuA gene" promotor_-35 290454..290460 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 290474..290493 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 290478 /Source="Nicolas_upshifts" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" downshifts 290830 /Source="Nicolas_upshifts" /id="D119" /incds=0 /nref=140 /ntot=250 /MaxReadThrough="6.07181" /MaxDrop="5.15011" /score="8.99106569" /energy="-15.9" /TU="U206,U208,U209" /idTUdmin="U206" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" CDS 290914..291609 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Zn(II) transporter (ATP-binding protein)" /protein_id="NP_388168.1" /db_xref="EnsemblGenomes-Gn:BSU02860" /db_xref="EnsemblGenomes-Tr:CAB12080" /db_xref="GOA:O34946" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12764" /db_xref="UniProtKB/Swiss-Prot:O34946" /translation="MNLVSLKDIVFGYSHTPVLDKVSLDIESGEFVGITGPNGASKST LIKVMLGMLKPWEGTVTISKRNTEGKRLTIGYVPQQISSFNAGFPSTVLELVQSGRYT KGKWFKRLNEEDHLEVEKALKMVEMWDLRHRKIGDLSGGQKQKICIARMLASNPDLLM LDEPTTAVDYDSRKGFYEFMHHLVKNHNRTVVMVTHEQNEVQQFLDKVIRLERGEKGG WKCLTWNSCDELF*" /label="znuC CDS" gene 290914..291609 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /label="znuC gene" CDS 291567..292409 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity Zn(II) ABC transporter (permease)" /protein_id="NP_388169.1" /db_xref="EnsemblGenomes-Gn:BSU02870" /db_xref="EnsemblGenomes-Tr:CAB12081" /db_xref="GOA:O34610" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12765" /db_xref="UniProtKB/Swiss-Prot:O34610" /translation="MEMFDLEFMRRAFLAGGMIAVMAPILGVYLVLRRQALMADTLSH ISLSGVAIGFFLSTNITAASIVVVTIGAIGIEYMRRAYRTYSEVSIAILMAAGLSFAM FLISLSKGTANMSIDQYLFGSLVTVNQQQVYIISIITLLILLYFIVLRRPLYLLTFDE ATAKTSGINTNVLSLSFSIVTGLAISVIIPIIGVLLVSALLVLPAAFAIRIAKGFNMV FITAILISLFSVFTGLTSSYQLGTPPGPSITLLLIVLLLIGFAVQGVWTFIKKEAQRK KRSR*" /label="znuB CDS" gene 291567..292409 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /label="znuB gene" downshifts 292396 /Source="Nicolas_upshifts" /id="D120" /incds=0 /nref=168 /ntot=266 /MaxReadThrough="2.4865" /MaxDrop="6.44929" /score="27.8218406" /energy="-13.6" /TU="NA" /idTUdmin="U206" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(292447..293442) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16428414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative luciferase-like monooxygenase" /protein_id="NP_388170.2" /db_xref="EnsemblGenomes-Gn:BSU02880" /db_xref="EnsemblGenomes-Tr:CAB12082" /db_xref="GOA:O34504" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12766" /db_xref="UniProtKB/Swiss-Prot:O34504" /translation="MIHLSILDQAPVSKGESPVTTLQHSVELAQLSEQWGYKRYWFAE HHSTKGLASTAPEIMIARIAAQTNTIRVGSGGVLLPQYSPFKVAETFRQLEALYPNRI DLGVGRSPGGTTKTRLALTDGVKKSLTEFNRQLQDVSYFLTDSLPPDHPYAGIKAAPL IGTAPELWVLGLGENSARRAAHQGIGYVFGHFINPERGENAFRIYRESFRPSAHFSNP SALFTIFVICAKTDEEAEELALSQDLWLLRVGKGLDSRVPSIEEAKAHPYTASDKKLI EENRKRMVIGSPTTVKQQLLDLTGCYETNEIMVLCNVFDFEAKKESYERLAELFL*" /label="yceB CDS" gene complement(292447..293442) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /label="yceB gene" promotor_-35 293398..293405 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-35" promotor_-10 293420..293439 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-10" S_feature 293426..293628 /Source="Nicolas_S_feature" /locus_tag="new_311859_312061" /HighExp="Diami, Etha, dia5, Salt, H2O2, dia15, Paraq, T-0.40H, T0.30H, G135" /AntisenseName="yceB" /AntisenseCor="0.84300534435872998" /AntisenseRegPval="-73.099999999999994" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S105" upshifts 293426 /Source="Nicolas_upshifts" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="upshifts" promotor_-10 complement(293474..293493) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(293482) /Source="Nicolas_upshifts" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(293508..293515) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 293612..293621 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 293630..293725 /Source="Nicolas_S_feature" /locus_tag="new_312063_312158" /HighExp="T0.0H, T-0.40H, T-1.10H, T0.30H, Salt, T1.0H, Etha, T-1.40H, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S106" upshifts 293630 /Source="Nicolas_upshifts" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 293634..293649 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 293726..294325 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388171.1" /db_xref="EnsemblGenomes-Gn:BSU02890" /db_xref="EnsemblGenomes-Tr:CAB12083" /db_xref="GOA:P81100" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12767" /db_xref="UniProtKB/Swiss-Prot:P81100" /translation="MAISLEKGQRIDLTKGKAGLSKLMVGLGWDPVSSGGGFFSKLLG GGGPNIDCDASVLMLENGKFTDKKNLIYFGNLKSRCGGVQHTGDNLTGDGAGDDEQIM IDLDKVPGNIDKLVFVVNIYDCVRRKQDFGMIQNAFIRVVDQSNHEEMLKYNLRDNYA GRTSLITAEIYRSGSEWKFAAVGEGTNDTRLEDIISRYV*" /label="yceC CDS" gene 293726..294325 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /label="yceC gene" CDS 294347..294928 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388172.1" /db_xref="EnsemblGenomes-Gn:BSU02900" /db_xref="EnsemblGenomes-Tr:CAB12084" /db_xref="GOA:P80875" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12768" /db_xref="UniProtKB/Swiss-Prot:P80875" /translation="MTISLAKGQKVDLTKTNPGLSKVVVGLGWDTNKYDGGHDFDLDS SVFLLDAAGKCASPNDFIFYNQLEGGNGSVVHSGDNLTGAGEGDDENVKVNLSAVPAN IDKISFVITIHDAEARSQNFGQVSNAFVRIVNEETNEELIRYDLAEDFSIETAIIAGE LYRHNGEWKFSAIGSGYQGGLARIATDYGLQVG*" /label="yceD CDS" gene 294347..294928 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /label="yceD gene" CDS 294963..295541 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388173.1" /db_xref="EnsemblGenomes-Gn:BSU02910" /db_xref="EnsemblGenomes-Tr:CAB12085" /db_xref="GOA:O34384" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12769" /db_xref="UniProtKB/Swiss-Prot:O34384" /translation="MAIQLSKGQRIDLTKTNPGLTKAVIGLGWDTNKYSGGHDFDLDA SAFLVDAHDNCVNDLDFVFYNNLEHPSGGVIHTGDNRTGEGDGDDEQIIVDFSKIPAH IEKIGITVTIHDAEARSQNFGQVSNAFVRVVDEETQNELLRFDLGEDFSIETAVVVCE LYRHGGEWKFNAIGSGFSGGLAALCRNYGLQV*" /label="yceE CDS" gene 294963..295541 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /label="yceE gene" CDS 295592..296365 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 24366250; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative stress adaptation transporter (tellurite resistance)" /protein_id="NP_388174.1" /db_xref="EnsemblGenomes-Gn:BSU02920" /db_xref="EnsemblGenomes-Tr:CAB12086" /db_xref="GOA:O34447" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="SubtiList:BG12770" /db_xref="UniProtKB/Swiss-Prot:O34447" /translation="MDFLHHILSTYASFFDWKMWGEVLTDPVSWGLIGSLVVLEGLLS ADNALVLAVMVKHLPEKQRKKALTYGLFGAYIFRFIFIGLGMLLIKFWWIKVLGALYL AWLVIKHFWIGEKEEEADGMKKNSWMVRTFGIFWATVISVELMDLAFSVDSILAAFAV SEKVWVLLIGGMLGILMMRTVAKVFLVLIDKIPELENTAFVLIGIIALKMAGSAFHYE MPHSVFFIIIIAAFAVTLIIHYINKQKQVREQTAASKEE*" /label="yceF CDS" gene 295592..296365 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /label="yceF gene" downshifts 296352 /Source="Nicolas_upshifts" /id="D121" /incds=0 /nref=46 /ntot=239 /MaxReadThrough="6.82513" /MaxDrop="4.0674" /score="4.0495978" /energy="-8.2" /TU="U212" /idTUdmin="U210" /TUdmin=2728 /isTUend="FALSE" /label="downshifts" CDS 296450..298063 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxic compound adaptation protein (tellurite resistance)" /protein_id="NP_388175.1" /db_xref="EnsemblGenomes-Gn:BSU02930" /db_xref="EnsemblGenomes-Tr:CAB12087" /db_xref="InterPro:IPR025647" /db_xref="SubtiList:BG12771" /db_xref="UniProtKB/Swiss-Prot:O34809" /translation="MRQEELTIHKALPADGDWKSLLFQPLPERDHYETAQGLSFSRLA GQILGTPIDETDYYNELYELSVNDRITILSETLDKTIEPETFQKLQHIHSINQKEKGL SVSRFVAFLDGEKLIAKHSNPLMHRHLRKALMTLLHTFADSHEKGLNHPDFRRVLLDV SKFSLNHLNPWLEKTDIEREMPKVVWYGDATKSQLYFLYYLMLVGCDVLLFHPAGTDQ LALVDPKQELGFTEKLPDVSELQPFPKEKPDRKSTVAYRSTKEIEHVLNHEESMLYKP WQFRDHTPVSVTLKTTYDELFLITKERAFIRPNFKADKHSIEIPNVFAKIMGVSKDNK EYWNRLHTLADYQETEMVRSFPFTEEIKSNYQFHYSHALDQEGNIDPDKLMASNVWQY KQLPAGVQTAIAKTISRMCRYPRLKALHQEQVKDVQIYLFKQTTNLPANLLKLIQMFD YAQTVPKLVLYHTEMSGGLTRSDAAALLFLNEIGIDIIIYNPPGHQDIEQFIEEDQYD IHWLDDMVFQQDYKEPSLVKRLFRTITQK*" /label="yceG CDS" gene 296450..298063 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /label="yceG gene" CDS 298079..299170 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative reactive oxygen species resistance protein" /protein_id="NP_388176.1" /db_xref="EnsemblGenomes-Gn:BSU02940" /db_xref="EnsemblGenomes-Tr:CAB12088" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG12772" /db_xref="UniProtKB/Swiss-Prot:O34833" /translation="MTTENQNPLVLDKNEEISQQKADDIRLQLRQEPEVKRLAQQIDV KNQMELLEYGKEPAVEISKFSDRILGMMKTTSVTDSGTMLTQLGKIMDRFDKNDFDEP KGLMAKIFKRGGSMIEKIFKKYQTLGGEIEKIHVEISKYKDEMTKTNYTLDEMYENNI KYYMELEKYVVAGQMKLEEMQSILPSYEEKAASGNQLAQMQLDTLRNGIQALEERVYD LDMARMVALQTAPQIRLLQRGNAKLIGKINSAFIITIPIFKNGIIQAVTVKRQKLVAD SMSELDRRTNEMLKRNAENISSQSVEIARMAGRPSIDIETIESSWNTIVSGMQETKQI EEENKRLREDGARRIAQLQDNIKKAALQQ*" /label="yceH CDS" gene 298079..299170 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /label="yceH gene" downshifts 299144 /Source="Nicolas_upshifts" /id="D122" /incds=0 /nref=85 /ntot=228 /MaxReadThrough="4.46836" /MaxDrop="4.05585" /score="-6.59172775" /energy="-17.5" /TU="U212" /idTUdmin="U212" /TUdmin="-1322" /isTUend="FALSE" /label="downshifts" promotor_-35 299224..299231 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 299246..299265 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 299254 /Source="Nicolas_upshifts" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="upshifts" CDS 299292..300494 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18276644, 21953179" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18276644, 21953179; Product type t: transporter" /codon_start=1 /transl_table=11 /product="niacin permease" /protein_id="NP_388177.1" /db_xref="EnsemblGenomes-Gn:BSU02950" /db_xref="EnsemblGenomes-Tr:CAB12089" /db_xref="GOA:O34691" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12773" /db_xref="UniProtKB/Swiss-Prot:O34691" /translation="MGKQQPISQRKLLGVAGLGWLFDAMDVGILSFIIAALHVEWNLS PEEMKWIGSVNSIGMAAGAFLFGLLADRIGRKKVFIITLLCFSIGSGISAFVTSLSAF LILRFVIGMGLGGELPVASTLVSEAVVPEKRGRVIVLLESFWAVGWLAAALISYFVIP SFGWQAALLLTALTAFYALYLRTSLPDSPKYESLSAKKRSMWENVKSVWARQYIRPTV MLSIVWFCVVFSYYGMFLWLPSVMLLKGFSMIQSFEYVLLMTLAQLPGYFSAAWLIEK AGRKWILVVYLIGTAGSAYFFGTADSLSLLLTAGVLLSFFNLGAWGVLYAYTPEQYPT AIRATGSGTTAAFGRIGGIFGPLLVGTLAARHISFSVIFSIFCIAILLAVACILIMGK ETKQTELE*" /label="niaP CDS" gene 299292..300494 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /label="niaP gene" downshifts 300474 /Source="Nicolas_upshifts" /id="D123" /incds=0 /nref=8 /ntot=184 /MaxReadThrough="4.1968" /MaxDrop="3.48367" /score="13.0427769" /energy="-10.6" /TU="U213" /idTUdmin="U212" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(300747..301919) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carbohydrate transporter (possibly exporter)" /protein_id="NP_388178.1" /db_xref="EnsemblGenomes-Gn:BSU02960" /db_xref="EnsemblGenomes-Tr:CAB12090" /db_xref="GOA:O34724" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12774" /db_xref="UniProtKB/Swiss-Prot:O34724" /translation="MNRIWLFFSVMFVIGTDTFLLSPLLPLLQDQFHVSTDLSGWMVS AYALGYALFAFIAGPISDRLNRKTVMLWGLAGFIVSTFLCGIAPSFAAMCLFRFAAGV SAAFVTPQIWASIPVIVQPSQIIKGMGIATAGLAASQMLGLPIGGFLASFTWHTPFFV LSACSLILLLILAAVMPGIRPSEPLARPSIVNPYRELFSLPKTSVILLAYFLFQTGNF ASFSFLGTWLSADYHLTVSQIGAAMLVLGLGNMLGSLIGSRVSEKLGMFKTLISGMLL MGALYFALPFFPNLFLVEAGFFLTFFTAGIIFPLMMGVFQSIAPNARGTIASLSNAAM YAGTTVGTSIAGFLYQSTQHFGAVTGFTAILFILSMTLYQTISKTGKRQSTARAQL*" /label="yceJ CDS" gene complement(300747..301919) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /label="yceJ gene" downshifts complement(300762) /Source="Nicolas_upshifts" /id="D124" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="2.6211" /MaxDrop="2.7452" /score="9.21991741" /energy="-12.6" /TU="NA" /idTUdmin="U214" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(301988..302290) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388179.1" /db_xref="EnsemblGenomes-Gn:BSU02970" /db_xref="EnsemblGenomes-Tr:CAB12091" /db_xref="GOA:O34464" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12775" /db_xref="UniProtKB/Swiss-Prot:O34464" /translation="MYYSFMTMKQSDDQIRAQIFKALSDESRLAIIRTLYVSGKELSC GEVGEKCNIVKTTASYHFKTLREAGLTATRKDSRTKYVSLREDTFQTYLPGFLETL*" /label="yceK CDS" gene complement(301988..302290) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /label="yceK gene" downshifts complement(302016) /Source="Nicolas_upshifts" /id="D125" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="5.67096" /MaxDrop="6.89889" /score="2.01231069" /energy="-4.8" /TU="U214" /idTUdmin="U214" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(302273..302292) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(302292) /Source="Nicolas_upshifts" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(302306..302312) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 302539..302558 /Source="Nicolas_upshift_promotors" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 302539 /Source="Nicolas_upshifts" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="upshifts" CDS 302580..303836 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(ATP-binding protein)" /protein_id="NP_388180.2" /db_xref="EnsemblGenomes-Gn:BSU02980" /db_xref="EnsemblGenomes-Tr:CAB12092" /db_xref="GOA:P46920" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11370" /db_xref="UniProtKB/Swiss-Prot:P46920" /translation="MSVDEKPIKIKVEKVSKIFGKQTKKAVQMLANGKTKKEILKATG STVGVNQADFEVYDGEIFVIMGLSGSGKSTLVRMLNRLIEPTAGNIYIDGDMITNMSK DQLREVRRKKISMVFQKFALFPHRTILENTEYGLELQGVDKQERQQKALESLKLVGLE GFEHQYPDQLSGGMQQRVGLARALTNDPDILLMDEAFSALDPLIRKDMQDELLDLHDN VGKTIIFITHDLDEALRIGDRIVLMKDGNIVQIGTPEEILMNPSNEYVEKFVEDVDLS KVLTAGHIMKRAETVRIDKGPRVALTLMKNLGISSIYAVDKQKKLLGVIYASDAKKAA ESDLSLQDILNTEFTTVPENTYLTEIFDVVSDANIPIAVVDEKQRMKGIVVRGALIGA LAGNNEYINAEGTNEQTQDPSAQEVK*" /label="opuAA CDS" gene 302580..303836 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /label="opuAA gene" downshifts complement(302588) /Source="Nicolas_upshifts" /id="D126" /incds=0 /nref=108 /ntot=175 /MaxReadThrough="2.83797" /MaxDrop="5.18503" /score="2.01231069" /energy="-4.8" /TU="NA" /idTUdmin="U214" /TUdmin="-1826" /isTUend="FALSE" /label="downshifts" CDS 303838..304686 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752321, 15849754, 16225868, 16645306, 16850406, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752321, 15849754, 16225868, 16645306, 16850406, 25012968; Product type t : transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(permease)" /protein_id="NP_388181.1" /db_xref="EnsemblGenomes-Gn:BSU02990" /db_xref="EnsemblGenomes-Tr:CAB12093" /db_xref="GOA:P46921" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11371" /db_xref="UniProtKB/Swiss-Prot:P46921" /translation="MDRLPRIPLADIIDRFVDWITMTFGGFFDGIANGLAAFVNGIVT GLGFIPSILLTIIFAALAWWISTRGIALFTLIGFLLIDYLGYWDPMLQTLALVLTSVI ISIVVGVPIGIWASQKETVRRIVTPILDLMQTMPAFVYLLPAIFFFNIGVVPGVVASV IFAMPPTIRMTVLGIKQVPADLIEATEAFGSTTAQRLFKVQLPLATKTILAGINQSIM LALSMVVIAAMVGAPGLGSEVYSAVTQLKTGVGVEAGIAIVIVAITLDRITQNIKVKK KSRGNA*" /label="opuAB CDS" gene 303838..304686 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /label="opuAB gene" CDS 304686..305567 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporterABC transporter (glycine betaine-binding lipoprotein)" /protein_id="NP_388182.1" /db_xref="EnsemblGenomes-Gn:BSU03000" /db_xref="EnsemblGenomes-Tr:CAB12094" /db_xref="GOA:P46922" /db_xref="InterPro:IPR007210" /db_xref="PDB:2B4L" /db_xref="PDB:2B4M" /db_xref="PDB:3CHG" /db_xref="SubtiList:BG11372" /db_xref="UniProtKB/Swiss-Prot:P46922" /translation="MLKKIIGIGVSAMLALSLAACGSENDENASAAEQVNKTIIGIDP GSGIMSLTDKAMKDYDLNDWTLISASSAAMTATLKKSYDRKKPIIITGWTPHWMFSRY KLKYLDDPKQSYGSAEEIHTITRKGFSKEQPNAAKLLSQFKWTQDEMGEIMIKVEEGE KPAKVAAEYVNKHKDQIAEWTKGVQKVKGDKINLAYVAWDSEIASTNVIGKVLEDLGY EVTLTQVEAGPMWTAIATGSADASLSAWLPNTHKAYAAKYKGKYDDIGTSMTGVKMGL VVPQYMKNVNSIEDLKK*" /label="opuAC CDS" gene 304686..305567 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /label="opuAC gene" downshifts 305548 /Source="Nicolas_upshifts" /id="D127" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="0.74967" /MaxDrop="8.21394" /score="33.6263027" /energy="-12.2" /TU="NA" /idTUdmin="U215" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(305580) /Source="Nicolas_upshifts" /id="D128" /incds=0 /nref=2 /ntot=62 /MaxReadThrough="4.29566" /MaxDrop="3.9514" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(305605..306756) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8768514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388183.2" /db_xref="EnsemblGenomes-Gn:BSU03010" /db_xref="EnsemblGenomes-Tr:CAB12095" /db_xref="GOA:P54983" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11789" /db_xref="UniProtKB/Swiss-Prot:P54983" /translation="MQKLSEEMKQTIMDIFEHLHANPEVSWKEYETTSFLKQKLEDLG CRTRTFSDCTGVVGEIGSGSPVVAVRADIDALWQEVNGTFRANHSCGHDSHMTMALGT LMLLKKQPELPKGTIRFIFQPAEEKGGGALKMIEEGVLDDIDYLYGVHVRPIQETQNG RCAPSILHGSSQHIEGTIIGEEAHGARPHLGKNSIEIAAFLVHKLGLIHIDPQIPHTV KMTKLQAGGESSNIIPGKASFSLDLRAQTNEAMEALIAETERACEAAAAAFGAKIELH KEHSLPAATQNKEAEAIMAEAITEIIGAERLDDPLVTTGGEDFHFYAVKVPNLKTTML GLGCGLQPGLHHPHMTFDRNAMFTGIHILANAVLKTFQKAESLAAANAS*" /label="amhX CDS" gene complement(305605..306756) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /label="amhX gene" downshifts complement(305624) /Source="Nicolas_upshifts" /id="D129" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="4.33606" /MaxDrop="3.5225" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" S_feature complement(306757..306844) /Source="Nicolas_S_feature" /locus_tag="new_325190_325277_c" /HighExp="Etha, T1.30H, M9-stat, T2.30H, S1, T3.30H, T5.0H, T4.0H, Sw, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S107" promotor_-35 306812..306819 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-35" promotor_-10 complement(306831..306850) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 306834..306853 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-10" upshifts complement(306844) /Source="Nicolas_upshifts" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="upshifts" upshifts 306847 /Source="Nicolas_upshifts" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="upshifts" promotor_-35 complement(306863..306869) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 306906..308339 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21747963, 21764931; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative branched chain amino acid permease" /protein_id="NP_388184.2" /db_xref="EnsemblGenomes-Gn:BSU03020" /db_xref="EnsemblGenomes-Tr:CAB12096" /db_xref="GOA:P55908" /db_xref="InterPro:IPR018385" /db_xref="SubtiList:BG11999" /db_xref="UniProtKB/Swiss-Prot:P55908" /translation="MSMPAAETQPKKKRMTFKMPDAYVLLFMIAFICAIASYIVPAGE FDRVTKGDVTTAVPGSYHSIEQSPVRLISFFTSLQDGMVGSAPIIFLILFTGGTIAIL EKTGAINGLIYNVISKFRTKQLLFICIVGALFSILGTTGIVVNSVIGFIPIGLIVARS LKWDAVAGAAVIYIGCYAGFNSTILSPSPLGLSQSIAELPLFSGIGLRVVIYICFLLS SIIYIYLYTRKLKKSKDASVLGTDWFPAAGMGEAGKEEDQSVPFTVRHKLILAVAGLS LVGFLYGALKLGWSDSQMAATFIFISVLAGLIGGLAANDIAKTFITGCQSLVYGALIV GMARSISVILENGKLLDTVVNALASLLDGFSPIAGAIGMYIASALLHFLISSGSGEAV VFIPILAPLADLMGITRQVAVEAVMLGEGVVNCVNPTSGVLMAVLAASGIPYVKWLRF MVPLALIWFLIGLVFIVIGVMINWGPF*" /label="ycgA CDS" gene 306906..308339 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /label="ycgA gene" promotor_-35 307644..307652 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 307664..307682 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 307683 /Source="Nicolas_upshifts" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 308321 /Source="Nicolas_upshifts" /id="D130" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="3.53497" /MaxDrop="3.31444" /score="12.0135493" /energy="-15.6" /TU="U217" /idTUdmin="U218" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 308382..308389 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 308404..308423 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 308413 /Source="Nicolas_upshifts" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="upshifts" CDS 308455..309036 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406, 22720735; Producttype m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_388185.2" /db_xref="EnsemblGenomes-Gn:BSU03030" /db_xref="EnsemblGenomes-Tr:CAB12097" /db_xref="SubtiList:BG12000" /db_xref="UniProtKB/Swiss-Prot:P55909" /translation="MNNLRNRLSGVNGKNKRVKEKEQKIWSEIGMIAGAFALLDVIIR GIMFEFPFKEWAASLVFLFIIILYYCIRAAASGMLMPRIDTKEELQKRVKQQRIESIA VAFAVVVLTMYDRGIPHTFFAWLKMILLFIVCGGVLFLLRYVIVKLAYRRAVKEEIKK KSSFLFGKRGKRSQFRAAFFIGTLICIHSAKLF*" /label="ycgB CDS" gene 308455..309036 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /label="ycgB gene" upshifts 308849 /Source="Nicolas_upshifts" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="upshifts" misc_feature 308853..308857 /Source="Nicolas_upshift_promotors" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 309012..309019 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 309034..309053 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 309047..309184 /Source="Nicolas_S_feature" /locus_tag="new_327480_327617" /HighExp="BC, M0t90, M40t90, S2, M9-stat, T4.0H, Sw, T3.30H, Lbtran, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.999, 0.242, 0.999" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S108" upshifts 309047 /Source="Nicolas_upshifts" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="upshifts" CDS 309185..311164 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /EC_number="3.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3117969, 9353930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3117969, 9353930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-amylase" /protein_id="NP_388186.2" /db_xref="EnsemblGenomes-Gn:BSU03040" /db_xref="EnsemblGenomes-Tr:CAB12098" /db_xref="GOA:P00691" /db_xref="InterPro:IPR006046" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR031319" /db_xref="InterPro:IPR031965" /db_xref="PDB:1BAG" /db_xref="PDB:1UA7" /db_xref="SubtiList:BG10473" /db_xref="UniProtKB/Swiss-Prot:P00691" /translation="MFAKRFKTSLLPLFAGFLLLFHLVLAGPAAASAETANKSNELTA PSIKSGTILHAWNWSFNTLKHNMKDIHDAGYTAIQTSPINQVKEGNQGDKSMSNWYWL YQPTSYQIGNRYLGTEQEFKEMCAAAEEYGIKVIVDAVINHTTSDYAAISNEVKSIPN WTHGNTQIKNWSDRWDVTQNSLLGLYDWNTQNTQVQSYLKRFLDRALNDGADGFRFDA AKHIELPDDGSYGSQFWPNITNTSAEFQYGEILQDSASRDAAYANYMDVTASNYGHSI RSALKNRNLGVSNISHYASDVSADKLVTWVESHDTYANDDEESTWMSDDDIRLGWAVI ASRSGSTPLFFSRPEGGGNGVRFPGKSQIGDRGSALFEDQAITAVNRFHNVMAGQPEE LSNPNGNNQIFMNQRGSHGVVLANAGSSSVSINTATKLPDGRYDNKAGAGSFQVNDGK LTGTINARSVAVLYPDDIAKAPHVFLENYKTGVTHSFNDQLTITLRADANTTKAVYQI NNGPETAFKDGDQFTIGKGDPFGKTYTIMLKGTNSDGVTRTEKYSFVKRDPASAKTIG YQNPNHWSQVNAYIYKHDGSRVIELTGSWPGKPMTKNADGIYTLTLPADTDTTNAKVI FNNGSAQVPGQNQPGFDYVLNGLYNDSGLSGSLPH*" /label="amyE CDS" gene 309185..311164 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /label="amyE gene" downshifts 311178 /Source="Nicolas_upshifts" /id="D131" /incds=0 /nref=57 /ntot=131 /MaxReadThrough="1.64783" /MaxDrop="6.55823" /score="-8.82332571" /energy="-3.4" /TU="U221" /idTUdmin="U219" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 311244..311251 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 311261 /Source="Nicolas_upshifts" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 311265..311284 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 311341..312306 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /EC_number="1.1.1.27" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10809684, 16207915, 19383131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 16207915, 19383131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lactate dehydrogenase" /protein_id="NP_388187.2" /db_xref="EnsemblGenomes-Gn:BSU03050" /db_xref="EnsemblGenomes-Tr:CAB12099" /db_xref="GOA:P13714" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011304" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR018177" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="PDB:3PQD" /db_xref="PDB:3PQE" /db_xref="PDB:3PQF" /db_xref="SubtiList:BG19003" /db_xref="UniProtKB/Swiss-Prot:P13714" /translation="MMNKHVNKVALIGAGFVGSSYAFALINQGITDELVVIDVNKEKA MGDVMDLNHGKAFAPQPVKTSYGTYEDCKDADIVCICAGANQKPGETRLELVEKNLKI FKGIVSEVMASGFDGIFLVATNPVDILTYATWKFSGLPKERVIGSGTTLDSARFRFML SEYFGAAPQNVHAHIIGEHGDTELPVWSHANVGGVPVSELVEKNDAYKQEELDQIVDD VKNAAYHIIEKKGATYYGVAMSLARITKAILHNENSILTVSTYLDGQYGADDVYIGVP AVVNRGGIAGITELNLNEKEKEQFLHSAGVLKNILKPHFAEQKVN*" /label="lctE CDS" gene 311341..312306 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /label="lctE gene" CDS 312338..313963 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10809684, 15849754, 16428414, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 15849754, 16428414, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_388188.2" /db_xref="EnsemblGenomes-Gn:BSU03060" /db_xref="EnsemblGenomes-Tr:CAB12100" /db_xref="GOA:P55910" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG12001" /db_xref="UniProtKB/Swiss-Prot:P55910" /translation="MWEQLYDPFGNEYVSALVALTPILFFLLALTVLKMKGILAAFLT LAVSFFVSVWAFHMPVEKAISSVLLGIGSGLWPIGYIVLMAVWLYKIAVKTGKFTIIR SSIAGISPDQRLQLLLIGFCFNAFLEGAAGFGVPIAISAALLVELGFKPLKAAALCLI ANAASGAFGAIGIPVITGAQIGDLSALELSRTLMWTLPMISFLIPFLLVFLLDRMKGI KQTWPALLVVSGGYTAVQTLTMAVLGPELANILAALFSMGGLALFLRKWQPKEIYREE GAGDAGEKKAYRAADIAKAWSPFYILTAAITIWSLPAFKALFQEGGLLYQSTLLFKMP FLHQQIMKMPPIAPSAMPLDAVFKVDLLSATGTAILAAVIVTGLFSKKFSSRDAFASL KETGKELWVPIMTICFVMGFANLANFAGLSSSIGLALAKTGDLFPFVSPVLGWIGVFI TGSVVSNNALFGHLQVVTGAQIGAGSDLLLAANTAGGVMAKLVSPQSIAIAAAAVGQT GKESKLFKRTVAYSLILLLIICIWTFILARLGV*" /label="lctP CDS" gene 312338..313963 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /label="lctP gene" downshifts 312344 /Source="Nicolas_upshifts" /id="D132" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="8.56142" /MaxDrop="2.8862" /score="-8.82332571" /energy="-3.4" /TU="U222" /idTUdmin="U221" /TUdmin=1144 /isTUend="FALSE" /label="downshifts" downshifts 313950 /Source="Nicolas_upshifts" /id="D133" /incds=0 /nref=51 /ntot=118 /MaxReadThrough="2.31168" /MaxDrop="7.73065" /score="39.575264" /energy="-15.6" /TU="NA" /idTUdmin="U222" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(314008..315546) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9023234, 15489457, 15849754, 16850406, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023234, 15489457, 15849754, 16850406, 21690368; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_388189.2" /db_xref="EnsemblGenomes-Gn:BSU03070" /db_xref="EnsemblGenomes-Tr:CAB12101" /db_xref="GOA:P96712" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12002" /db_xref="UniProtKB/Swiss-Prot:P96712" /translation="MDTTTAKQASTKFVVLGLLLGILMSAMDNTIVATAMGNIVADLG SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLIFFLIGSALCGIAQTMNQ LIIFRAIQGIGGGALLPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGAIIT DSISWHWVFYINVPIGALSLFFIIRYYKESLEHRKQKIDWGGAITLVVSIVCLMFALE LGGKTYDWNSIQIIGLFIVFAVFFIAFFIVERKAEEPIISFWMFKNRLFATAQILAFL YGGTFIILAVFIPIFVQAVYGSSATSAGFILTPMMIGSVIGSMIGGIFQTKASFRNLM LISVIAFFIGMLLLSNMTPDTARVWLTVFMMISGFGVGFNFSLLPAASMNDLEPRFRG TANSTNSFLRSFGMTLGVTIFGTVQTNVFTNKLNDAFSGMKGSAGSGAAQNIGDPQEI FQAGTRSQIPDAILNRIIDAMSSSITYVFLLALIPIVLAAVTILFMGKARVKTTAEMT KKAN*" /label="mdr CDS" gene complement(314008..315546) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /label="mdr gene" downshifts complement(314026) /Source="Nicolas_upshifts" /id="D134" /incds=0 /nref=70 /ntot=182 /MaxReadThrough="1.04964" /MaxDrop="4.53635" /score="30.8374042" /energy="-15.6" /TU="NA" /idTUdmin="U225" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(314600..314700) /Source="Nicolas_upshift_promotors" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(314640) /Source="Nicolas_upshifts" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 315560..315564 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 315580..315599 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 315594 /Source="Nicolas_upshifts" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(315626..315645) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(315629) /Source="Nicolas_upshifts" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="upshifts" CDS 315659..316123 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388190.2" /db_xref="EnsemblGenomes-Gn:BSU03080" /db_xref="EnsemblGenomes-Tr:CAB12102" /db_xref="GOA:O31472" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12003" /db_xref="UniProtKB/Swiss-Prot:O31472" /translation="MSTRNSRSELEKTAVQLFRKLGTRTVLFHQAAAQALGLFPTDLK SADILNEAGPMTAGELGKKTGLSTGSVTALVDRLEKAGYVAREKDPNDRRRVVIVPLT ASKKHIKDLFRPLSESTMDLCREYTEEELELIFSFVGKAADIMEEELERLKQ*" /label="ycgE CDS" gene 315659..316123 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /label="ycgE gene" promotor_-35 complement(315660..315666) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 316133..316138 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 316154..316172 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 316164 /Source="Nicolas_upshifts" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="upshifts" CDS 316197..316826 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid export permease" /protein_id="NP_388191.1" /db_xref="EnsemblGenomes-Gn:BSU03090" /db_xref="EnsemblGenomes-Tr:CAB12103" /db_xref="GOA:P94381" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG12004" /db_xref="UniProtKB/Swiss-Prot:P94381" /translation="MNIFLSYIVLGLSLSAPVGPVNAAQIDKGIKNGFWHAWIFGLGA MTADGLYMLFIYFGLSQFLTAPFVKTFLWLFGFFVLTYTGIETLKNVREPMDVRSSRG KPSYRKTFASGFLISLSNPLSILFWLGIYGSILAKTAEAYNMNQLLIYSSGIMIGILI WDFCMAITASTFRNLLHEKLLRGLTGIAGVSLLVFGFYFGYQGIKQLLG*" /label="ycgF CDS" gene 316197..316826 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /label="ycgF gene" promotor_-35 316837..316846 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 316860..316879 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 316868 /Source="Nicolas_upshifts" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="upshifts" CDS 316896..317657 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (similar to phage protein)" /protein_id="NP_388192.2" /db_xref="EnsemblGenomes-Gn:BSU03100" /db_xref="EnsemblGenomes-Tr:CAB12104" /db_xref="InterPro:IPR014988" /db_xref="SubtiList:BG12005" /db_xref="UniProtKB/Swiss-Prot:P94382" /translation="MVNGIYTKSFLERIQEELPEWQRIAFELLAETLGDDADTFPCIP GRQAFLTDQLRIAFAGDPRENRTAEELAPLLAEYGKISRDTGKYASLVVLFDTPEDLA EHYSIEAYEELFWRFLNRLSHQDEKEWPEDIPADPEHYKWEFCFDGEPYFILCATPGH EARRSRSFPFFMVTFQPRWVFDDLNGSTAFGRNMSRLIRSRLEAYDQAPIHPQLGWYG GKDNREWKQYFLRDDEKQVSKCPFSYLKNMFNKMK*" /label="ycgG CDS" gene 316896..317657 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /label="ycgG gene" S_feature complement(317296..317658) /Source="Nicolas_S_feature" /locus_tag="new_335729_336091_c" /HighExp="S8, S7, S5, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="ycgG" /AntisenseCor="0.73875580854115197" /AntisenseRegPval="-46.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S109" downshifts 317654 /Source="Nicolas_upshifts" /id="D135" /incds=0 /nref=21 /ntot=174 /MaxReadThrough="1.53211" /MaxDrop="4.92685" /score="6.36985882" /energy="-8.6" /TU="NA" /idTUdmin="U227" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(317659..318999) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid transporter" /protein_id="NP_388193.2" /db_xref="EnsemblGenomes-Gn:BSU03110" /db_xref="EnsemblGenomes-Tr:CAB12105" /db_xref="GOA:P94383" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12006" /db_xref="UniProtKB/Swiss-Prot:P94383" /translation="MSQTKKDQPKGNLAWWQLSLIGVGCTIGTGFFLGSSIAIVKSGF SVLLSFLIAGIGTYFVFEQLAKLSAKQPEKGSFCAYARKAFGKWAGFSNGWVYWTSEM LITGSQLTAISLFTKHWFPQVPLWVFASIYAVLGLLIIFTGLSVFEKTENVLAVIKTA AIFMFIVIAILALCGILSGGNHGIHVPNKTSEFFPYGAMGLWTGLIYAFYAFGGIEVM GLMAVHLKKPEEASKSGKLMLATLAIIYIISIGLALLLVPLHTFTEQDSPFITSLKGY NLEIILDIFNGIFIIAGFSTLVASLFAVTTLLCTMADDGDAPKCFTLKEGKKICWPAL GLTFAGLVLSIILSLVLPKNIYEHMTTAAGLMLLYTWLFILFSSKKLTDPEGMGKTQI YLAMVLIAAAVSGTLFEKSSRPGFFVSIGFLVIIAIVTMIYQKKQGHKDRPASP*" /label="ycgH CDS" gene complement(317659..318999) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /label="ycgH gene" promotor_-10 complement(319026..319037) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(319036) /Source="Nicolas_upshifts" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(319052..319058) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 319078..319084 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 319092 /Source="Nicolas_upshifts" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 319099..319110 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 319129..319725 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16433904, 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388194.3" /db_xref="EnsemblGenomes-Gn:BSU03120" /db_xref="EnsemblGenomes-Tr:CAB12106" /db_xref="InterPro:IPR018959" /db_xref="SubtiList:BG12007" /db_xref="UniProtKB/Swiss-Prot:O31473" /translation="MTQQYIVEPKKGLGLKLKKGQILKVVDVEGQQVADFVAYHAKDF YEHLDQGATIDANHSIHVKVNDHLYSNLYKPMLTLIEDTVGKHDLLLPACRPDMNRLL YGKQKDEFQDTCYDNMNRALEQFGVPKPHMHYPFAIFMNTVLDEKGNLSVETPLSNAG DYVRLRAEMDLIVAFSSCPIEKGKCNGDSVTSIRVEVS*" /label="ycgI CDS" gene 319129..319725 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /label="ycgI gene" promotor_-35 319733..319740 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 319754..319854 /Source="Nicolas_S_feature" /locus_tag="new_338187_338287" /HighExp="dia15, LBGtran, dia5, Etha, dia0, LBGexp, M0t45, Lbexp, Diami, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S110" promotor_-10 319754..319773 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 319754 /Source="Nicolas_upshifts" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(319850) /Source="Nicolas_upshifts" /id="D136" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="1.2989" /MaxDrop="4.67402" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS 319855..320673 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /EC_number="6.3.1.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7890752, 9271869, 12682299, 19204287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7890752, 9271869, 12682299, 19204287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ammonium-dependent NAD+ synthetase" /protein_id="NP_388195.1" /db_xref="EnsemblGenomes-Gn:BSU03130" /db_xref="EnsemblGenomes-Tr:CAB12107" /db_xref="GOA:P08164" /db_xref="InterPro:IPR003694" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022926" /db_xref="PDB:1EE1" /db_xref="PDB:1FYD" /db_xref="PDB:1IFX" /db_xref="PDB:1IH8" /db_xref="PDB:1KQP" /db_xref="PDB:1NSY" /db_xref="PDB:2NSY" /db_xref="SubtiList:BG10694" /db_xref="UniProtKB/Swiss-Prot:P08164" /translation="MSMQEKIMRELHVKPSIDPKQEIEDRVNFLKQYVKKTGAKGFVL GISGGQDSTLAGRLAQLAVESIREEGGDAQFIAVRLPHGTQQDEDDAQLALKFIKPDK SWKFDIKSTVSAFSDQYQQETGDQLTDFNKGNVKARTRMIAQYAIGGQEGLLVLGTDH AAEAVTGFFTKYGDGGADLLPLTGLTKRQGRTLLKELGAPERLYLKEPTADLLDEKPQ QSDETELGISYDEIDDYLEGKEVSAKVSEALEKRYSMTEHKRQVPASMFDDWWK*" /label="nadE CDS" gene 319855..320673 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /label="nadE gene" downshifts 320655 /Source="Nicolas_upshifts" /id="D137" /incds=0 /nref=144 /ntot=271 /MaxReadThrough="2.68866" /MaxDrop="6.24927" /score="20.6612287" /energy="-14.1" /TU="U230" /idTUdmin="U230" /TUdmin="-65" /isTUend="FALSE" /label="downshifts" CDS complement(320723..321316) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1624425, 7766032, 15131133, 27315722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624425, 7766032, 15131133, 27315722; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATP-binding tunicamycin resistance protein" /protein_id="NP_388196.2" /db_xref="EnsemblGenomes-Gn:BSU03140" /db_xref="EnsemblGenomes-Tr:CAB12108" /db_xref="GOA:P12921" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10456" /db_xref="UniProtKB/Swiss-Prot:P12921" /translation="MIIWINGAFGSGKTQTAFELHRRLNPSYVYDPEKMGFALRSMVP QEIAKDDFQSYPLWRAFNYSLLASLTDTYRGILIVPMTIVHPEYFNEIIGRLRQEGRI VHHFTLMASKETLLKRLRTRAEGKNSWAAKQIDRCVEGLSSPIFEDHIQTDNLSIQDV AENIAARAELPLDPDTRGSLRRFADRLMVKLNHIRIK*" /label="tmrB CDS" gene complement(320723..321316) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /label="tmrB gene" downshifts complement(320730) /Source="Nicolas_upshifts" /id="D138" /incds=0 /nref=10 /ntot=143 /MaxReadThrough="0.60282" /MaxDrop="3.74815" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=682 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(321331..321350) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(321346) /Source="Nicolas_upshifts" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(321365..321368) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(321374..321522) /Source="Nicolas_S_feature" /locus_tag="new_339807_339955_c" /HighExp="S4, S3, S6, S5, S7, BT, S8, LoTm, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S111" promotor_-35 321424..321431 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 321444..321463 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 321446..321554 /Source="Nicolas_S_feature" /locus_tag="new_339879_339987" /HighExp="Diami, BMM, GM 15, GM 25, GM 120, GM 60, GM 10, G180, GM 45, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S112" upshifts 321448 /Source="Nicolas_upshifts" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(321516..321534) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 321522..321529 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(321532) /Source="Nicolas_upshifts" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 321544..321563 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(321550..321555) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 321556 /Source="Nicolas_upshifts" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="upshifts" CDS 321592..322152 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /EC_number="2.7.1.71" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 170268, 7612934, 27339308; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate kinase" /protein_id="NP_388197.2" /db_xref="EnsemblGenomes-Gn:BSU03150" /db_xref="EnsemblGenomes-Tr:CAB12109" /db_xref="GOA:P37944" /db_xref="InterPro:IPR000623" /db_xref="InterPro:IPR023000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031322" /db_xref="SubtiList:BG10457" /db_xref="UniProtKB/Swiss-Prot:P37944" /translation="MNAKRAIPVRERNIVLIGFMGVGKTTIGQLVAKKLYRDFIDIDQ QIEKDFNMSIPEIFEKKGEDFFRKTEKEYILDICHHKRFKIVSLGGGSFKQEEIRNCC LENCLVLHLDLSWENWKQRADLLIESRPVLHNRSMDEMEQLFNERKVIYDKHNSKVAT DNLSPEEVADYIVETLKIGWDLYQPM*" /label="aroK CDS" gene 321592..322152 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /label="aroK gene" downshifts 322129 /Source="Nicolas_upshifts" /id="D139" /incds=0 /nref=21 /ntot=239 /MaxReadThrough="2.07607" /MaxDrop="4.67156" /score="44.9099474" /energy="-13.1" /TU="NA" /idTUdmin="U232" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(322180..322941) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388198.2" /db_xref="EnsemblGenomes-Gn:BSU03160" /db_xref="EnsemblGenomes-Tr:CAB12110" /db_xref="GOA:O31474" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XXL" /db_xref="PDB:2GLU" /db_xref="SubtiList:BG12008" /db_xref="UniProtKB/Swiss-Prot:O31474" /translation="MTNETPFSKNAEMYRDEKVFAEGEDLGLMIKTAECRAEHRVLDI GAGAGHTALAFSPYVQECIGVDATKEMVEVASSFAQEKGVENVRFQQGTAESLPFPDD SFDIITCRYAAHHFSDVRKAVREVARVLKQDGRFLLVDHYAPEDPVLDEFVNHLNRLR DPSHVRESSLSEWQAMFSANQLAYQDIQKWNLPIQYDSWIKRGGTPADREKQIITHLN HASDEARDTFCITLNQNGQPISFCLKAILIQGIKR*" /label="ycgJ CDS" gene complement(322180..322941) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /label="ycgJ gene" downshifts complement(322204) /Source="Nicolas_upshifts" /id="D140" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.31391" /MaxDrop="3.85249" /score="18.9843263" /energy="-13.1" /TU="NA" /idTUdmin="U235" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(322973..322992) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 322974..322981 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(322979) /Source="Nicolas_upshifts" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 322996..323015 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(323007..323012) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 323008 /Source="Nicolas_upshifts" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="upshifts" CDS 323059..324033 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_388199.2" /db_xref="EnsemblGenomes-Gn:BSU03170" /db_xref="EnsemblGenomes-Tr:CAB12111" /db_xref="GOA:P94387" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12009" /db_xref="UniProtKB/Swiss-Prot:P94387" /translation="MDIKVMEYAAEIARRQSFTKAAEHLHIAQPSLSQQIKKLEAELG LTLFHRSHGSVTLTPHGRRFIEKAEDIIRSRDDLLREMQERSQGIGHKLSIGIPAVTG RYLFPPLLKQFLARYPHVEVQLVEKDPVSLEKMTAKGEVDLSVLSLPIEDERLSITPL LTEPVVLAVPKEKQRWMPPELVALIEKALEEDEGRQPCVPIDMVRNVPFILLKEGFGF RRTVLDLCAESGFKPNAAFKTSHIETAQSLVANGLGVTMAPNMVRRDKDPGVIYLSIQ SAPSRTLVFVFLKNRYVSLTAQAFMELSRESLKQTFDEGCLGNKDENI*" /label="ycgK CDS" gene 323059..324033 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /label="ycgK gene" S_feature 324034..324104 /Source="Nicolas_S_feature" /locus_tag="new_342467_342537" /HighExp="Diami, dia5, dia15, S1, dia0, C90, LBGexp, Heat, Lbexp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S113" CDS 324105..325061 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /EC_number="3.1.1.41" /EC_number="3.1.1.72" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12842474, 19837798, 21382014" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12842474, 19837798, 21382014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acetyl xylan esterase-cephalosporin C deacetylase" /protein_id="NP_388200.1" /db_xref="EnsemblGenomes-Gn:BSU03180" /db_xref="EnsemblGenomes-Tr:CAB12112" /db_xref="GOA:P94388" /db_xref="InterPro:IPR008391" /db_xref="InterPro:IPR029058" /db_xref="PDB:1L7A" /db_xref="PDB:1ODS" /db_xref="PDB:1ODT" /db_xref="SubtiList:BG11919" /db_xref="UniProtKB/Swiss-Prot:P94388" /translation="MQLFDLPLDQLQTYKPEKTAPKDFSEFWKLSLEELAKVQAEPDL QPVDYPADGVKVYRLTYKSFGNARITGWYAVPDKEGPHPAIVKYHGYNASYDGEIHEM VNWALHGYATFGMLVRGQQSSEDTSISPHGHALGWMTKGILDKDTYYYRGVYLDAVRA LEVISSFDEVDETRIGVTGGSQGGGLTIAAAALSDIPKAAVADYPYLSNFERAIDVAL EQPYLEINSFFRRNGSPETEVQAMKTLSYFDIMNLADRVKVPVLMSIGLIDKVTPPST VFAAYNHLETKKELKVYRYFGHEYIPAFQTEKLAFFKQHLKG*" /label="cah CDS" gene 324105..325061 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /label="cah gene" promotor_-35 324520..324526 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 324541..324552 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 324548 /Source="Nicolas_upshifts" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="upshifts" S_feature 325062..325140 /Source="Nicolas_S_feature" /locus_tag="new_343495_343573" /HighExp="dia5, dia15, Diami, dia0, B36, S1, MG 10, BT, B60, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S114" promotor_-35 325115..325120 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 325137..325155 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 325142 /Source="Nicolas_upshifts" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="upshifts" CDS 325145..325927 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388201.1" /db_xref="EnsemblGenomes-Gn:BSU03190" /db_xref="EnsemblGenomes-Tr:CAB12113" /db_xref="InterPro:IPR018775" /db_xref="SubtiList:BG12010" /db_xref="UniProtKB/Swiss-Prot:P94389" /translation="MKQRIIDELKRIEQSYGVKIVYAVESGSRAWGFPSQDSDYDVRF IYVPKKEWYFSIEQERDVIEEPIHDLLDISGWELRKTLRLFKKSNPPLLEWLSSDIVY YEAFTTAEQLRKLRTEAFKPEASVYHYINMARRNVKDYLQGQEVKIKKYFYVLRPILA CQWIEKHGTIPPMDFTVLMNELVAEPELKAEMETLLERKRRGEELDLEARIDVIHQFI ETEIERIMEAAKELKAEKKDMTSELNRLLLNTVEEVWKDGGS*" /label="ycgL CDS" gene 325145..325927 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /label="ycgL gene" downshifts 325892 /Source="Nicolas_upshifts" /id="D141" /incds=0 /nref=11 /ntot=63 /MaxReadThrough="3.94077" /MaxDrop="4.37398" /score="0.421649027" /energy="-5.9" /TU="U238" /idTUdmin="U236" /TUdmin=2 /isTUend="TRUE" /label="downshifts" S_feature 325937..326064 /Source="Nicolas_S_feature" /locus_tag="new_344370_344497" /HighExp="S5, S6, S8, S4, S7, B36, B60, BT, S3, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S115" promotor_-35 326041..326045 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 326060..326079 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 326066 /Source="Nicolas_upshifts" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 326118..327029 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /EC_number="1.5.5.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17536821, 2118500, 21840319, 22139509, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17536821, 2118500, 21840319, 22139509, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline oxidase" /protein_id="NP_388202.1" /db_xref="EnsemblGenomes-Gn:BSU03200" /db_xref="EnsemblGenomes-Tr:CAB12114" /db_xref="GOA:P94390" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG12011" /db_xref="UniProtKB/Swiss-Prot:P94390" /translation="MITRDFFLFLSKSGFLNKMARNWGSRVAAGKIIGGNDFNSSIPT IRQLNSQGLSVTVDHLGEFVNSAEVARERTEECIQTIATIADQELNSHVSLKMTSLGL DIDMDLVYENMTKILQTAEKHKIMVTIDMEDEVRCQKTLDIFKDFRKKYEHVSTVLQA YLYRTEKDIDDLDSLNPFLRLVKGAYKESEKVAFPEKSDVDENYKKIIRKQLLNGHYT AIATHDDKMIDFTKQLAKEHGIANDKFEFQMLYGMRSQTQLSLVKEGYNMRVYLPYGE DWYGYFMRRLAERPSNIAFAFKGMTKK*" /label="putB CDS" gene 326118..327029 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /label="putB gene" CDS 327046..328593 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 17183215, 21840319, 22139509, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 17183215, 21840319, 22139509, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-pyrroline-5-carboxylate dehydrogenase" /protein_id="NP_388203.2" /db_xref="EnsemblGenomes-Gn:BSU03210" /db_xref="EnsemblGenomes-Tr:CAB12115" /db_xref="GOA:P94391" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12012" /db_xref="UniProtKB/Swiss-Prot:P94391" /translation="MTTPYKHEPFTNFQDQNNVEAFKKALATVSEYLGKDYPLVINGE RVETEAKIVSINPADKEEVVGRVSKASQEHAEQAIQAAAKAFEEWRYTSPEERAAVLF RAAAKVRRRKHEFSALLVKEAGKPWNEADADTAEAIDFMEYYARQMIELAKGKPVNSR EGEKNQYVYTPTGVTVVIPPWNFLFAIMAGTTVAPIVTGNTVVLKPASATPVIAAKFV EVLEESGLPKGVVNFVPGSGAEVGDYLVDHPKTSLITFTGSREVGTRIFERAAKVQPG QQHLKRVIAEMGGKDTVVVDEDADIELAAQSIFTSAFGFAGQKCSAGSRAVVHEKVYD QVLERVIEITESKVTAKPDSADVYMGPVIDQGSYDKIMSYIEIGKQEGRLVSGGTGDD SKGYFIKPTIFADLDPKARLMQEEIFGPVVAFCKVSDFDEALEVANNTEYGLTGAVIT NNRKHIERAKQEFHVGNLYFNRNCTGAIVGYHPFGGFKMSGTDSKAGGPDYLALHMQA KTISEMF*" /label="putC CDS" gene 327046..328593 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /label="putC gene" promotor_-35 328017..328023 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 328037..328056 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 328045 /Source="Nicolas_upshifts" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 328128..328134 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 328147..328166 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 328156 /Source="Nicolas_upshifts" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="upshifts" misc_feature 328592..328596 /Source="Nicolas_upshift_promotors" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 328594..328716 /Source="Nicolas_S_feature" /locus_tag="new_347027_347149" /HighExp="S1, T2.0H, T2.30H, Lbstat, aero, HiOs, BC, Sw, LPh, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52312199999999998" /TUshortSig="Sig-, SigA, SigA, SigA, SigEF" /TUshortPSig="0.249, 1, 0.994, 0.922, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S116" upshifts 328596 /Source="Nicolas_upshifts" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 328717..330138 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline permease" /protein_id="NP_388204.2" /db_xref="EnsemblGenomes-Gn:BSU03220" /db_xref="EnsemblGenomes-Tr:CAB12116" /db_xref="GOA:P94392" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12013" /db_xref="UniProtKB/Swiss-Prot:P94392" /translation="MLLIGYFAYKRTSNLTDYMLGGRSLGPAVTALSAGAADMSGWLL MGLPGAMFSTGLSGAWIVIGLCLGAWANWLYVAPRLRTYTEKAGNSITIPGFLENRFG DQTKLLRLFSGIVILVFFTFYVSSGMVSGGVLFNSILGMDYHTGLWIVTGVVVAYTLF GGFLAVSWTDFVQGIIMFAALILVPIVTFFHTGGAGDTVAEIRSVDPDMFNIFKGTSV LGIISLFAWGLGYFGQPHIIVRFMAITSVKEIKRARRIGMGWMILSAVGAVLTGLGGI AYYHQRGMTLKDPETIFIQLGNILFHPIITGFLISAILAAIMSTISSQLLVTSSSLVE DLYKSMFRRSASDKELVFLGRLAVLAVSIVALVLAWEKNNTILGLVSYAWAGFGASFG PVVLLSLFWKRMTKWGALAGMIVGAATVIIWANAGLSDFLYEMIPGFAASLLSVFFVS ILTQAPSQAVTDQFNDYQDTMSQ*" /label="putP CDS" gene 328717..330138 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /label="putP gene" S_feature complement(329237..331092) /Source="Nicolas_S_feature" /locus_tag="new_347670_349525_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, C30, T4.0H, Lbstat" /AntisenseName="ycgP" /AntisenseCor="0.143781082577395" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.679" /TUlongSig="NA" /TUlongPSig="NA" /label="S117" downshifts 330118 /Source="Nicolas_upshifts" /id="D142" /incds=0 /nref=21 /ntot=160 /MaxReadThrough="5.09597" /MaxDrop="4.17771" /score="5.89792272" /energy="-15.9" /TU="U239,U240,U242" /idTUdmin="U238" /TUdmin=4 /isTUend="TRUE" /label="downshifts" S_feature 330163..330259 /Source="Nicolas_S_feature" /locus_tag="new_348596_348692" /HighExp="S1, LPh, T2.0H, HPh, aero, Lbstat, LoTm, T2.30H, Cold, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.249, 0.994, 0.922" /TUlongSig="NA" /TUlongPSig="NA" /label="S118" promotor_-35 330230..330237 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 330252..330271 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 330261 /Source="Nicolas_upshifts" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 330291..331526 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21840319, 21964733, 22139509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21840319, 21964733, 22139509; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of proline degradationoperon" /protein_id="NP_388205.2" /db_xref="EnsemblGenomes-Gn:BSU03230" /db_xref="EnsemblGenomes-Tr:CAB12117" /db_xref="GOA:P94393" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12014" /db_xref="UniProtKB/Swiss-Prot:P94393" /translation="MEELLERVFSFSDVDKLIDFISYELQKPVILESADFFLLAYNSY YINHFDSANQQTIFSKKCPVQIFERFLKDGIIEKLKTEPEPFRVNKIESIGLNQRVVV SAKHKGEVMGYIWIQELDQNLTDEELDFLYETSFHVGKIIYKTNKLKQEKEEKAEDLI KRAIYQQFTSEKELRREAERINTVLPSMFSVVILHAANGDGEAVEDLKENIRSYLNLR DKVSHVLTIESNIVIVVASFSQKSSVSSAASEFINKLLTHFHFQKIPTPIYIGIGNEY NHLLKLGKSYTEALEVIKAAEITGNQENIPYEYAKLGIYRYLESIEQKNEFLEYENKD LALLKAKDEESSTELLKTLEIYLLNNCKTKPAAEQLFIHQNTLNYRIKQITEMTSIDL SDFRTRCQLYLDLMLMKKK*" /label="putR CDS" gene 330291..331526 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /label="putR gene" promotor_-10 complement(331085..331103) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(331102) /Source="Nicolas_upshifts" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(331117..331124) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(331510) /Source="Nicolas_upshifts" /id="D143" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="0.0291099999999993" /MaxDrop="3.08474" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=66 /isTUend="FALSE" /label="downshifts" CDS complement(331563..332420) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388206.1" /db_xref="EnsemblGenomes-Gn:BSU03240" /db_xref="EnsemblGenomes-Tr:CAB12118" /db_xref="GOA:P94394" /db_xref="InterPro:IPR015402" /db_xref="SubtiList:BG12015" /db_xref="UniProtKB/Swiss-Prot:P94394" /translation="MFRLLVLMGFTFFFYHLHASGNLTKYINMKYAYLSFIAIFLLAI LTAVQAYLFIKSPEKSGHHHDHDCGCGHDHEHDHEQNKPFYQRYLIYVVFLFPLVSGI FFPIATLDSSIVKTKGFSFKAMESGDHYSQTQYLRPDASLYYAQDSYDKQMKQLFNKY SSKKEISLTDDDFLKGMETIYNYPGEFLGRTIEFHGFAYKGNAINKNQLFVLRFGIIH CIADSGVYGMLVEFPKDMDIKDDEWIHIKGTLASEYYQPFKSTLPVVKVTDWNTIKKP DDPYVYRGF*" /label="ycgQ CDS" gene complement(331563..332420) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /label="ycgQ gene" downshifts complement(331576) /Source="Nicolas_upshifts" /id="D144" /incds=0 /nref=48 /ntot=167 /MaxReadThrough="1.97725" /MaxDrop="4.53007" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(332425..333309) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388207.1" /db_xref="EnsemblGenomes-Gn:BSU03250" /db_xref="EnsemblGenomes-Tr:CAB12119" /db_xref="GOA:P94395" /db_xref="InterPro:IPR005524" /db_xref="SubtiList:BG12016" /db_xref="UniProtKB/Swiss-Prot:P94395" /translation="MTAQSSFLQLNSIFISILIEAIPFILIGVILSGIIQMFVSEEMI ARIMPKNRFLAVLFGALAGVLFPACECGIIPITRRLLLKGVPLHAGVAFMLTAPIINP IVLFSTYIAFGNRWSVVFYRGGLALAVSLIIGVILSYQFKDNQLLKPDEPGHHHHHHG TLLQKLGGTLRHAIDEFFSVGKYLIIGAFIAAAMQTYVKTSTLLAIGQNDVSSSLVMM GLAFVLSLCSEVDAFIASSFSSTFSLGSLIAFLVFGAMVDIKNLLMMLAAFKKRFVFL LITYIVVIVLAGSLLVKG*" /label="ycgR CDS" gene complement(332425..333309) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /label="ycgR gene" upshifts complement(333361) /Source="Nicolas_upshifts" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(333366..333379) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(333394..333402) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(333409..334263) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /EC_number="3.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic hydrocarbon hydrolase" /protein_id="NP_388208.1" /db_xref="EnsemblGenomes-Gn:BSU03260" /db_xref="EnsemblGenomes-Tr:CAB12120" /db_xref="GOA:P94396" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12017" /db_xref="UniProtKB/Swiss-Prot:P94396" /translation="MKRRVETITFDGGTLEYSVTGKGTPILVMHGGHSNCYEEFGYTA LIEQGYSIITPSRPGYGRTSKEIGKSLANACRFYVKLLDHLQIESVHVIAISAGGPSG ICFASHYPERVNTLTLQSAVTKEWLTPKDTEYKLGEILFRPPVEKWIWKLISSLNNAF PRLMFRAMSPQFSTLPFQRIKSLMNEKDIEAFRKMNSRQRSGEGFLIDLSQTAAVSLK DLQAIICPVLIMQSVYDGLVDLSHAHHAKEHIRGAVLCLLHSWGHLIWLGKEAAETGS ILLGFLES*" /label="ycgS CDS" gene complement(333409..334263) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /label="ycgS gene" promotor_-10 complement(334282..334301) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-10" upshifts complement(334302) /Source="Nicolas_upshifts" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="upshifts" promotor_-35 complement(334316..334319) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-35" misc_feature 334353..334372 /Source="Nicolas_upshift_promotors" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(334353..334371) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 334360..334424 /Source="Nicolas_S_feature" /locus_tag="new_352793_352857" /HighExp="B60, Lbexp, LBGexp, dia0, B36, HiOs, GM 15, GM 10, Salt, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S119" upshifts 334361 /Source="Nicolas_upshifts" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(334370) /Source="Nicolas_upshifts" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(334387..334392) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 334425..335435 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /EC_number="1.18.1.-" /EC_number="1.8.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16672620, 25826316" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 25826316; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Fur-regulated NADPH:ferredoxin oxidoreductase" /protein_id="NP_388209.1" /db_xref="EnsemblGenomes-Gn:BSU03270" /db_xref="EnsemblGenomes-Tr:CAB12121" /db_xref="GOA:O31475" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12018" /db_xref="UniProtKB/Swiss-Prot:O31475" /translation="MAENQEVYDVTIIGGGPIGLFTAFYCGMRELKTKVIEFLPKLGG KVSLFFPEKIIRDIGGIPGIAGKQLIEQLKEQAATFDPDIVLNQRVTGFERLDDGTIV LTGSEGKKHYTRTVILACGMGTLEVNEFDSEDAARYAGKNLHYGVEKLDAFKGKRVVI SGGGDTAVDWANELEPIAASVTVVHRREEFGGMESSVTKMKQSSVRVLTPYRLEQLNG DEEGIKSVTVCHTESGQRKDIEIDELIINHGFKIDLGPMMEWGLEIEEGRVKADRHMR TNLPGVFVAGDAAFYESKLRLIAGGFTEGPTAVNSAKAYLDPKAENMAMYSTHHKKLV HK*" /label="ffoR CDS" gene 334425..335435 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /label="ffoR gene" S_feature 335436..337883 /Source="Nicolas_S_feature" /locus_tag="new_353869_356316" /HighExp="B60, Lbexp, GM 10, GM 25, HiOs, GM 15, dia0, GM 45, LBGexp, H2O2" /AntisenseName="nasF" /AntisenseCor="-0.30348565853404702" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S120" CDS complement(335467..336918) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /EC_number="2.1.1.107" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9765565, 10217486, 15028686" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765565, 10217486, 15028686; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrin-III C-methyltransferase" /protein_id="NP_388210.1" /db_xref="EnsemblGenomes-Gn:BSU03280" /db_xref="EnsemblGenomes-Tr:CAB12122" /db_xref="GOA:P42437" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR012409" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG11098" /db_xref="UniProtKB/Swiss-Prot:P42437" /translation="MIMKNGIVYFVGAGPGDPGLLTIKGKQALKEADVILYDRLANPK LLEFASPDCQFIYCGKLPNRHFMKQKEINALLVEKALNGLTVVRLKGGDPSVFGRVGE EADALHEHGIRYEMVPGITSGIAAPLYAGIPVTHRDFASSFAMITAHDKSLKGTPNLD WEGLARSVQTLVFYMGVKNLSYICQQLISYGKSPSVPVIVIQWGTWGRQRSVKGTLEN IQQKVQEHQITNPAIIVIGDIVNFQTHSWFESKPLIGRHLMVVTHGEDEDPLADKLRD SGADLIEWPKWRTENMPVNEEILRKIGTFEDVFFTSRRAVCEFFRALASQKIDIRQLT AKLSAASEQAKTELEKRGFLVTAIQPDSEKRLVVGSRHAVENMQKHESCSFYITHENV IDDRFTHMIQRTISESPLHMVICPNKLSVQQLINGGEQIGILPEPSASRPPIVCIGDD SAAGIYGFTAVQEQDELLAFIHNQHAEKKLLHT*" /label="nasF CDS" gene complement(335467..336918) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /label="nasF gene" downshifts complement(335471) /Source="Nicolas_upshifts" /id="D145" /incds=0 /nref=131 /ntot=230 /MaxReadThrough="1.40657" /MaxDrop="6.58881" /score="10.9556399" /energy="-11.7" /TU="NA" /idTUdmin="U250" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(336979..337299) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 15028686, 9765565, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 15028686, 9765565, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388211.1" /db_xref="EnsemblGenomes-Gn:BSU03290" /db_xref="EnsemblGenomes-Tr:CAB12123" /db_xref="GOA:P42436" /db_xref="InterPro:IPR012748" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11097" /db_xref="UniProtKB/Swiss-Prot:P42436" /translation="MVNKDVTKVCIGKIEELPEQLGKTVYIEDKELAVFKLSDGSIRA IENRCPHKGGVLAEGIVSGQYVFCPMHDWKISLEDGIVQEPDHGCVKTYETLIEGEHV YLVY*" /label="nasE CDS" gene complement(336979..337299) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /label="nasE gene" promotor_-35 337150..337155 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 337169..337173 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 337176 /Source="Nicolas_upshifts" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(337208) /Source="Nicolas_upshifts" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(337210..337229) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(337243..337250) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(337331..339748) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565, 16428414, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565, 16428414, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388212.1" /db_xref="EnsemblGenomes-Gn:BSU03300" /db_xref="EnsemblGenomes-Tr:CAB12124" /db_xref="GOA:P42435" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11096" /db_xref="UniProtKB/Swiss-Prot:P42435" /translation="MGKKQLVLVGNGMAGVRAIEEILSVAKDEFQITIFGAEPHPNYN RILLSKVLQGDTDIKDITLNDWDWYEENNIQLYTNETVIKVDTENKTVITDADRIQPY DELILATGSVPFILPIPGADKKGVTAFRDIKDTDTMLAASKQYKKAAVIGGGLLGLEA ARGLLNLGMDVSVIHLAPFLMERQLDATAGRLLQNELEKQGMTFLLEKQTEEIVGDDR VEGLRFKDGTSIEADLVVMAVGIRPNTTLGAESGIPVNRGIIVNDYMQTEIPHIYAVG ECAEHRGIAYGLVAPLYEQAKVLAKHMCGIETKPYEGSVLSTQLKVSGVEVFSAGDFN ESEEKKAIKVFDEQDGIYKKIVLRGNQIVGAVLFGDSSEGNRLFSMIQKEADISETSK ISILQPLSQEAGTSITAAMSDDEIICGCNGVSKGAIIQAIQEKGCSSTDEIKACTGAS RSCGGCKPLVEEILQHTLGSDFDASAQKEAICGCTTLSRDEVVEEIKAKGLSHTREVM NVLGWKTPEGCSKCRPALNYYLGMINPTKYEDDRTSRFVNERMHANIQKDGTYSVVPR MYGGVTNSTDLRKIADVVDKYEIPLVKMTGGQRIDLIGVKKEDLPKVWEDLDMPSGYA YGKTLRTVKTCVGEQFCRFGTQDSMALGIALEKKFEGLNTPHKVKMAVSACPRNCAES GIKDLGVVGIDGGWELYVGGNGGTHLRAGDLLMKVKTNEEVLEYAGAYLQYYRETANY LERTSAWLERVGLSHVQSVLNDPEKRQELNGRMNETLSVHKDPWKDFLEDKQTSKELF ENVVTTS*" /label="nasD CDS" gene complement(337331..339748) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /label="nasD gene" promotor_-10 complement(339773..339792) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(339787) /Source="Nicolas_upshifts" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(339804..339810) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(339870..342002) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /EC_number="1.7.99.4" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (catalytic subunit)" /protein_id="NP_388213.2" /db_xref="EnsemblGenomes-Gn:BSU03310" /db_xref="EnsemblGenomes-Tr:CAB12125" /db_xref="GOA:P42434" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="SubtiList:BG11095" /db_xref="UniProtKB/Swiss-Prot:P42434" /translation="MTERLLRYFRDKQQDVQSEKTYDTQCPFCSMQCKMQLVEQTIVT RKKYTAIGIDNPTTQGRLCIKGMNAHQHALNSSRITRPLLKKNGEFMPVSWEEALNHI KDQVTMIQTEHGHDAMAVYGSASITNEEAYLLGKFARVGLQTKYIDYNGRLCMSAAAT AANQTFGADRGLTNPLSDIPHTRVIILAGTNIAECQPTIMPYFEKAKENGAYFIAIDP RETATTKIADLHLKIKPGTDAALANGLVKIIIDEQLINEDFIQSRTNGFEELKQHTDS LDLNDIAEQTSVSLVDIRKAAVKFAKETSGMLFTARGIEQQTDGTAAVKGFLNMVLIT GKIGKPYSGYGAITGQGNGQGAREHGQKADQLPGYRSIENEEHRAHIAKVWGIHQDEL PRKGVSAYEMMEKINDGDIKGLFLMCSNPAVSSPNANLVKKALRRLTFFVAIDLFISE TAKYADVILPASSYLEDEGTMTNVEGRVTLREASRPCPGEAKHDWQIICDLASALGKG RYFSYTSAEDIFNELREASRGGIADYSGISYGRLRREGGIHWPCPESDHPGTGRLFTE SFAHPDQKAALSVIPNEPPVPKEKPTADYPLYLTTGRVMSHYLTGVQTRKSAALAARH FESFMEIHPQTAATYNIEDRVLVKIESPRGSITVRSKLSEQIRKDTVFVPIHWADAQN VNDLIGEALDPACKMPGFKVCAVRIIPI*" /label="nasC CDS" gene complement(339870..342002) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /label="nasC gene" CDS complement(342009..344324) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /EC_number="1.7.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (electron transfer subunit NasB)" /protein_id="NP_388214.2" /db_xref="EnsemblGenomes-Gn:BSU03320" /db_xref="EnsemblGenomes-Tr:CAB12126" /db_xref="GOA:P42433" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11094" /db_xref="UniProtKB/Swiss-Prot:P42433" /translation="MKKQRLVLAGNGMAGIRCIEEVLKLNRHMFEIVIFGSEPHPNYN RILLSSVLQGEASLDDITLNSKDWYDKHGITLYTGETVIQIDTDQQQVITDRKRTLSY DKLIVATGSSPHILPIPGADKKGVYGFRTIEDCQALMNMAQHFQKAAVIGAGLLGLEA AVGLQHLGMDVSVIHHSAGIMQKQLDQTAARLLQTELEQKGLTFLLEKDTVSISGATK ADRIHFKDGSSLKADLIVMAAGVKPNIELAVSAGIKVNRGIIVNDFMQTSEPNIYAVG ECAEHNGTVYGLVAPLYEQGKALASHICGVPCEEYQGSAPSAALKIAGIDVWSAGKIQ EDERTTSIKIYDEQAGVYKKALFVDDKLAGVILFGDTRDKQRLLDSLLKQRDISIAKK QIIEPETSGPLFESMPSSETICQCNTVTKGAIEDAVHTNSLTTVEEVKHCTKATGSCG GCKPLVEDLLRYMTNSEYTKPASTPSFCSCTDFTEDDIIAELQRRPFTNPAEVMNQLD WKTKNGCSTCVPAIQYYLEMLYPGFVQPEPATEETCILIPQMYGGRTNAEQLRTIANI IEAYSIPDVSITHGQRLKLSGIKPADLPNMKKDLKMPVYTNEHRHALQSIKACTCGQN RSIQQLAAQIERQLEMLPLPAPISISLSCETDCTEAALQDVGAIRTQAGWDIHIGGVR GTHARSGALFCVTENEDSTAGMIKGLIQYYRETAHYLEGVHQWIDRLGIVHIREVLFE EDLRAQLLESLQTDLSLIQNPTVETGAYKKG*" /label="nasB CDS" gene complement(342009..344324) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /label="nasB gene" promotor_no_box complement(344343..344443) /Source="Nicolas_upshift_promotors" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(344383) /Source="Nicolas_upshifts" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 344426..344433 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 344447..344466 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 344459 /Source="Nicolas_upshifts" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="upshifts" CDS 344504..345709 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7868621, 12823818, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative nitrate transporter" /protein_id="NP_388215.2" /db_xref="EnsemblGenomes-Gn:BSU03330" /db_xref="EnsemblGenomes-Tr:CAB12127" /db_xref="GOA:P42432" /db_xref="InterPro:IPR004737" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11093" /db_xref="UniProtKB/Swiss-Prot:P42432" /translation="MKLSELKTSGHPLTLLCSFLYFDVSFMIWVMLGALGVYISQDFG LSPFEKGLVVAVPILSGSVFRIILGILTDRIGPKKTAVIGMLVTMIPLLWGTFGGRSL TELYAIGILLGVAGASFAVALPMASRWYPPHLQGLAMGIAGAGNSGTLFATLFGPRLA EQFGWHIVMGIALIPLLIVFILFVSMAKDSPAQPSPQPLKSYLHVFGQKETWFFCLLY SVTFGGFVGLSSFLSIFFVDQYQLSKIHAGDFVTLCVAAGSFFRPVGGLISDRVGGTK VLSVLFVIVALCMAGVSSLPSLSMVIVLLFVGMMGLGMGNGAVFQLVPQRFRKEIGMV TGIVGAAGGIGGFFLPNILGSLKQMTGTYAIGFITFSCIALLAFALVLAAGYYWRKSW SAESSPADV*" /label="nasA CDS" gene 344504..345709 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /label="nasA gene" downshifts 345694 /Source="Nicolas_upshifts" /id="D146" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.02479" /MaxDrop="3.6823" /score="39.2612286" /energy="-11.9" /TU="NA" /idTUdmin="U253" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 345753..345759 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-35" promotor_-10 345774..345793 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-10" upshifts 345782 /Source="Nicolas_upshifts" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="upshifts" CDS 345826..346740 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12426338, 17032654, 19767425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12426338, 17032654, 19767425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_388216.2" /db_xref="EnsemblGenomes-Gn:BSU03340" /db_xref="EnsemblGenomes-Tr:CAB12128" /db_xref="GOA:P94398" /db_xref="InterPro:IPR003801" /db_xref="InterPro:IPR022838" /db_xref="SubtiList:BG12019" /db_xref="UniProtKB/Swiss-Prot:P94398" /translation="MNQHTLLPKKTERLQYFGSVSPIKGEKPVEKEKMKDLQNIRKDY FFDIQHVGVANVSHPVTITSAMMPAEQTTAANFTMTCNLPRNQKGINMSRLTELLQVY HQNGWILSFSSLQQFTKELAENMDTSSATVEVRFPWFFERKSPKLEKAGLMHADIFMS VTYRKDQPFKQRAGISAKVTTLCPCSKEISEYSAHNQRGTVSIWADIHPAASLPSDVK ADLLHAAESNASARLHPVLKRPDEKAVTETAYENPRFVEDLARLIAADLFELEWVSAF EIECRNEESIHLHDAYAKLCFSKEVDKI*" /label="folEB CDS" gene 345826..346740 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /label="folEB gene" CDS 346737..347321 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12426338, 20013255; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative Zn(2+)-dependent division lipoprotein (schizosome)" /protein_id="NP_388217.2" /db_xref="EnsemblGenomes-Gn:BSU03350" /db_xref="EnsemblGenomes-Tr:CAB12129" /db_xref="GOA:C0SP99" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG12020" /db_xref="UniProtKB/Swiss-Prot:C0SP99" /translation="MKLSLFIIAVLMPVILLSACSDHAEEHASINTKKTVENITDVRK TAKTSIDWTKPSGGEYPDIKQKHVWIDVNVKEQKAYIKEGSNTIYTMMISSGLDQTKD DATPKGTFYVEPERGEWFFSEGYQEGAEYWVSWKNHGEFLFHSVPMTKDQKVIKTEAE KLGTKASHGCIRLTIPDAKWVYENIPEHTKVVIS*" /label="yciB CDS" gene 346737..347321 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /label="yciB gene" promotor_-35 347332..347339 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 347353..347372 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 347363 /Source="Nicolas_upshifts" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="upshifts" CDS 347417..347602 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097674.1" /db_xref="EnsemblGenomes-Gn:BSU03359" /db_xref="EnsemblGenomes-Tr:CAX52544" /db_xref="UniProtKB/Swiss-Prot:C0H3U7" /translation="MKSGKASIKDLAVGKGKDLRWGKGLNAVGVFTDLEIGRQREMSA KSCSTPLYIRRSIQFKS*" /label="yczL CDS" gene 347417..347602 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /label="yczL gene" CDS 347630..348823 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249; Product type t: transporter" /codon_start=1 /transl_table=11 /product="zinc metallochaperone with NTPase activity" /protein_id="NP_388218.1" /db_xref="EnsemblGenomes-Gn:BSU03360" /db_xref="EnsemblGenomes-Tr:CAB12130" /db_xref="GOA:P94400" /db_xref="InterPro:IPR003495" /db_xref="InterPro:IPR011629" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036627" /db_xref="SubtiList:BG12021" /db_xref="UniProtKB/Swiss-Prot:P94400" /translation="MKKIPVTVLSGYLGAGKTTLLNSILQNREGLKIAVIVNDMSEVN IDAGLVKQEGGLSRTDEKLVEMSNGCICCTLREDLLIEVEKLAKDGRFDYIVIESTGI SEPIPVAQTFSYIDEEMGIDLTKFCQLDTMVTVVDANRFWHDYQSGESLLDRKEALGE KDEREIADLLIDQIEFCDVLILNKCDLVSEQELEQLENVLRKLQPRARFIRSVKGNVK PQEILHTGLFNFEEASGSAGWIQELTAGHAEHTPETEEYGISSFVYKRRLPFHSTRFY RWLDQMPKNVVRAKGIVWCASHNNLALLMSQAGPSVTIEPVSYWVAALPKLEQEQVKQ QEPEILEEWDPEFGDRLTQLVFIGTDLDEETITKELDQCLLTEYEFDSDWSLFEDPFK WKLNQ*" /label="zinU CDS" gene 347630..348823 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /label="zinU gene" downshifts 348815 /Source="Nicolas_upshifts" /id="D147" /incds=0 /nref=26 /ntot=45 /MaxReadThrough="5.12378" /MaxDrop="5.8275" /score="15.6427627" /energy="-9.2" /TU="U255" /idTUdmin="U255" /TUdmin="-792" /isTUend="FALSE" /label="downshifts" S_feature 348860..350529 /Source="Nicolas_S_feature" /locus_tag="new_367293_368962" /HighExp="Etha, B60, Cold, Heat, B36, C30, BMM, S6, C90, S2" /AntisenseName="yckB" /AntisenseCor="-0.170121935628575" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S121" CDS complement(348872..349552) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aminoacid ABC transporter (permease subunit)" /protein_id="NP_388219.1" /db_xref="EnsemblGenomes-Gn:BSU03370" /db_xref="EnsemblGenomes-Tr:CAB12131" /db_xref="GOA:P42399" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11177" /db_xref="UniProtKB/Swiss-Prot:P42399" /translation="MINSIQWEYIFNTKLAIESFPYVIKGIGYTLLISFVSMFAGTVI GLFISLARMSKLALLRWPAKLYISFMRGVPILVILFILYFGFPYIGIEFSAVTAALIG FSLNSAAYIAEINRSAISSVEKGQWEAASSLGLSYWQTMRGIILPQSIRIALPPLANV LLDLIKASSLAAMITVPELLQHAKIIGGREFDYMTMYILTALIYWAICSIAAVFQNIL EKKYAHYV*" /label="yckA CDS" gene complement(348872..349552) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /label="yckA gene" downshifts complement(348878) /Source="Nicolas_upshifts" /id="D148" /incds=0 /nref=101 /ntot=231 /MaxReadThrough="0.41655" /MaxDrop="6.18136" /score="40.1548023" /energy="-12.6" /TU="NA" /idTUdmin="U256" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(349562..350425) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23038252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="amino acid ABC transporter (binding lipoprotein subunit)" /protein_id="NP_388220.1" /db_xref="EnsemblGenomes-Gn:BSU03380" /db_xref="EnsemblGenomes-Tr:CAB12132" /db_xref="GOA:P42400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="PDB:2IEE" /db_xref="SubtiList:BG11178" /db_xref="UniProtKB/Swiss-Prot:P42400" /translation="MKSFMHSKAVIFSFTMAFFLILAACSGKNEADSKDTGWEQIKDK GKIVVATSGTLYPTSYHDTDSGSDKLTGYEVEVVREAAKRLGLKVEFKEMGIDGMLTA VNSGQVDAAANDIDVTKDREEKFAFSTPYKYSYGTAIVRKDDLSGIKTLKDLKGKKAA GAATTVYMEVARKYGAKEVIYDNATNEQYLKDVANGRTDVILNDYYLQTLALAAFPDL NITIHPDIKYMPNKQALVMKKSNAALQKKMNEALKEMSKDGSLTKLSKQFFNKADVSK KIDADVQDVDL*" /label="yckB CDS" gene complement(349562..350425) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /label="yckB gene" promotor_-10 complement(350447..350466) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(350459) /Source="Nicolas_upshifts" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(350461..353295) /Source="Nicolas_S_feature" /locus_tag="new_368894_371728_c" /HighExp="GM 150, T-4.40H, G/S, Pyr, S2, C30, T-5.40H, C90, T-3.40H, T0.30H" /AntisenseName="bglC" /AntisenseCor="-0.37749573319969598" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, Sig-" /TUshortPSig="0.248, 0.994, 0.0879" /TUlongSig="SigD" /TUlongPSig=1 /label="S122" promotor_-35 complement(350481..350488) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 350498..350504 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 350519..350537 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 350531..350753 /Source="Nicolas_S_feature" /locus_tag="new_368964_369186" /HighExp="Etha, Salt, B60, Sw, B36, Gly, Heat, S6, Cold, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99896700000000005" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S123" upshifts 350531 /Source="Nicolas_upshifts" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="upshifts" CDS 350587..350784 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513942.1" /translation="MSKDECQTYQGNACESEGCSRPVTHLCQYRKKWSRGMKPIFRIN LSLADAPKAYDIFDEKENGNI*" /label="hypothetical protein CDS" gene 350587..350784 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /label="gene" promotor_-35 350722..350727 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 350743..350761 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 350755 /Source="Nicolas_upshifts" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="upshifts" CDS 350803..351258 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral membrane protein of unknown function" /protein_id="NP_388221.1" /db_xref="EnsemblGenomes-Gn:BSU03390" /db_xref="EnsemblGenomes-Tr:CAB12133" /db_xref="GOA:P42401" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11179" /db_xref="UniProtKB/Swiss-Prot:P42401" /translation="MNIYKPAGFWIRLGAALLDYIIVSVPLLLIYWLITGKDPNDSMF ISLVVLLYSILLPMFWRGYLIGKRICGIRIVKKDGSQVSLLTMFLRVIVAGLVYCITF GLGLIASLILIAVREDKRTLHDLIAGTYVTYATPGEEELNADEEIRKSE*" /label="yckC CDS" gene 350803..351258 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /label="yckC gene" downshifts 351233 /Source="Nicolas_upshifts" /id="D149" /incds=0 /nref=40 /ntot=193 /MaxReadThrough="1.14817" /MaxDrop="5.48303" /score="23.1539807" /energy="-9.8" /TU="NA" /idTUdmin="U257" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 351281..351287 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 351294 /Source="Nicolas_upshifts" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 351301..351312 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 351340..351672 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388222.1" /db_xref="EnsemblGenomes-Gn:BSU03400" /db_xref="EnsemblGenomes-Tr:CAB12134" /db_xref="InterPro:IPR024485" /db_xref="SubtiList:BG11180" /db_xref="UniProtKB/Swiss-Prot:P42402" /translation="MKRITINIITMFIAAAVISLTGTAEAAEKQQQSPANVTLTDQQK KEIEQLEAEILKKRKDVISKYVQYGILPKERGEHIKNHLDKHFEMMKQNGFVPKHHPH PHKFEKRH*" /label="yckD CDS" gene 351340..351672 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /label="yckD gene" downshifts 351653 /Source="Nicolas_upshifts" /id="D150" /incds=0 /nref=20 /ntot=44 /MaxReadThrough="2.48743" /MaxDrop="4.3022" /score="-1.40416926" /energy="-11.8" /TU="NA" /idTUdmin="U259" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 351758..351765 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 351781..351800 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 351785 /Source="Nicolas_upshifts" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="upshifts" CDS 351826..353259 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916, 18069788" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916, 18069788; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_388223.1" /db_xref="EnsemblGenomes-Gn:BSU03410" /db_xref="EnsemblGenomes-Tr:CAB12135" /db_xref="GOA:P42403" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11181" /db_xref="UniProtKB/Swiss-Prot:P42403" /translation="MIHQHPESFPKHFLWGSASAAYQIEGAWNEDGKGPSVWDVFTKI PGKTFKGTNGEIAVDHYHRFKEDVALMAEMGLKAYRFSVSWPRVFPKGKGEINEAGLA FYDSLIDELLSHHIEPVLTLYHWDLPQALMDEYGGFESRNIIEDFNHYCITLYKRFGD RVKYWVTLNEQNYNFNHGFITAMHPPGVKDRKRFYEANHIAFLANAKAIESFREYVPE GKIGPSFAYSPAYPLSSHPEDILAFENAEEFTNNWWLDMYCWGTYPQIPFRCLEKQGW APTIEAGDMDLLAKGKPDFVGVNYYQTITYERNPLDGVSEGKMNTTGQKGTNQETGIP GVFKTKKNPHLTTSNWDWTIDPIGLRIGLRRITSRYQLPVFITENGLGEFDKVEDGTV QDDYRIDYLRSHLEQCRQAISDGVDLIGYCSWSFTDLLSWLNGYQKRYGFVYVNRDEE STSDLKRLKKKSFYWYQDVIKTNGESL*" /label="bglC CDS" gene 351826..353259 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /label="bglC gene" downshifts 353237 /Source="Nicolas_upshifts" /id="D151" /incds=0 /nref=12 /ntot=61 /MaxReadThrough="1.51167" /MaxDrop="4.6748" /score="18.0928088" /energy="-15.9" /TU="NA" /idTUdmin="U260" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(353296..353694) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11359569, 11814663, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11359569, 11814663, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the DNA degrading activity of NucA (competence)" /protein_id="NP_388224.1" /db_xref="EnsemblGenomes-Gn:BSU03420" /db_xref="EnsemblGenomes-Tr:CAB12136" /db_xref="GOA:P12669" /db_xref="InterPro:IPR020354" /db_xref="PDB:4MQD" /db_xref="SubtiList:BG10839" /db_xref="UniProtKB/Swiss-Prot:P12669" /translation="MIKSWKPQELSISYHQFTVFQKDSTPPVMDWTDEAIEKGYAAAD GAISFEAQRNTKAFILFRLNSSETVNSYEKKVTVPFHVTENGIHIESIMSKRLSFDLP KGDYQLTCWTVPAEMSDLHADTYIIDAVSV*" /label="nin CDS" gene complement(353296..353694) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /label="nin gene" promotor_no_box complement(353691..353791) /Source="Nicolas_upshift_promotors" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="promotor_no_box" CDS complement(353721..354170) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2841296, 7746143, 11359569, 11814663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2841296, 7746143, 11359569, 11814663; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease" /protein_id="NP_388225.3" /db_xref="EnsemblGenomes-Gn:BSU03430" /db_xref="EnsemblGenomes-Tr:CAB12137" /db_xref="GOA:P12667" /db_xref="InterPro:IPR029476" /db_xref="SubtiList:BG10838" /db_xref="UniProtKB/Swiss-Prot:P12667" /translation="MNITTDIIKTILLVIVIIAAAAVGLIKGDFFSADQKTSQTKEYD ETMAFPSDRYPETAKHIKDAINEGHSEVCTIDRDGAEERREQSLKDVPSKKGYDRDEW PMAMCKEGGEGASVEYISPADNRGAGSWVGHRLTDYPDGTKVLFTIQ*" /label="nucA CDS" gene complement(353721..354170) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /label="nucA gene" upshifts complement(353731) /Source="Nicolas_upshifts" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(354185..354204) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(354193) /Source="Nicolas_upshifts" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(354195..354337) /Source="Nicolas_S_feature" /locus_tag="new_372628_372770_c" /HighExp="C30, Diami, M40t45, Cold, Lbstat, T0.30H, M0t90, dia15, C90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD" /TUshortPSig="0.0879, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S124" promotor_-35 complement(354218..354225) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(354338..356059) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7704255, 7921238, 15187186, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704255, 7921238, 15187186, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (plant colonization)" /protein_id="NP_388226.2" /db_xref="EnsemblGenomes-Gn:BSU03440" /db_xref="EnsemblGenomes-Tr:CAB12138" /db_xref="GOA:P39209" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="SubtiList:BG10790" /db_xref="UniProtKB/Swiss-Prot:P39209" /translation="MLIKRFKMKLGTKILCLVFVVILLFSASVGTVMLKEITESMKQM ATEKAKGDLALSSTYIDDVMSGDWQVKNNKLYKGQTQINGNEDIVDLLGEKTGDTITI FQGDTRVATNVMKNGERAVGTQASSEVIAAVLKKGKRFYGQADVAGSSYQTAYMPLKD QNGNIIGMLYTGANQSILASLTQSLFTQFAIVLVIVIMVSVILVLVFTRKINKRLNAL KSAFESAGNGDMTIEVSDKTGDELSELSVYYNKMRMKLNDTIQTVQQSALQLASASQQ LSAGAEETNQASEKITEAVQQIANGAQDQITRIENSESSLKQASADIRDISANTAAIA DKGQLAQSKADIGQKEIANVQAQMDAIHQSIQKSGEIIHQLDGRSKQIEQILSVITQI ADQTNLLALNAAIEAARAGEQGKGFAVVADEVRKLAEESQQSAGQISKLIIEIQKDMN RSARSVEHVKTEAAEGVTMIQRTRDAFKEIAAATGEISAEISDLSASVTNISASAHQI NDSFAANTADIKESTKNTRQAAALTEEQFAAMEEITAASETLSQLAEELTGIISQFKM INQAENG*" /label="tlpC CDS" gene complement(354338..356059) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /label="tlpC gene" promotor_-35 354350..354357 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 354368..357511 /Source="Nicolas_S_feature" /locus_tag="new_372801_375944" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, T4.0H, T0.0H, T-0.40H" /AntisenseName="tlpC" /AntisenseCor="-0.40398083053643302" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S125" upshifts 354368 /Source="Nicolas_upshifts" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 354372..354391 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box complement(354373..354473) /Source="Nicolas_upshift_promotors" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="promotor_no_box" upshifts complement(354413) /Source="Nicolas_upshifts" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="upshifts" promotor_-10 complement(356083..356101) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-10" upshifts complement(356098) /Source="Nicolas_upshifts" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="upshifts" promotor_-35 complement(356115..356122) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-35" CDS complement(356170..356727) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /EC_number="5.3.1.27" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-3-hexuloisomerase (PHI)" /protein_id="NP_388227.1" /db_xref="EnsemblGenomes-Gn:BSU03450" /db_xref="EnsemblGenomes-Tr:CAB12139" /db_xref="GOA:P42404" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR017552" /db_xref="PDB:1M3S" /db_xref="PDB:1VIV" /db_xref="SubtiList:BG11182" /db_xref="UniProtKB/Swiss-Prot:P42404" /translation="MKTTEYVAEILNELHNSAAYISNEEADQLADHILSSHQIFTAGA GRSGLMAKSFAMRLMHMGFNAHIVGEILTPPLAEGDLVIIGSGSGETKSLIHTAAKAK SLHGIVAALTINPESSIGKQADLIIRMPGSPKDQSNGSYKTIQPMGSLFEQTLLLFYD AVILKLMEKKGLDSETMFTHHANLE*" /label="hxlB CDS" gene complement(356170..356727) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /label="hxlB gene" downshifts complement(356173) /Source="Nicolas_upshifts" /id="D152" /incds=0 /nref=51 /ntot=130 /MaxReadThrough="1.98332" /MaxDrop="6.56052" /score="42.3682356" /energy="-15.4" /TU="NA" /idTUdmin="U266" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(356733..357365) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /EC_number="4.1.2.43" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hexulose-6-phosphate synthase (HPS)" /protein_id="NP_388228.1" /db_xref="EnsemblGenomes-Gn:BSU03460" /db_xref="EnsemblGenomes-Tr:CAB12140" /db_xref="GOA:P42405" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017553" /db_xref="SubtiList:BG11183" /db_xref="UniProtKB/Swiss-Prot:P42405" /translation="MELQLALDLVNIPEAIELVKEVEQYIDVVEIGTPVVINEGLRAV KEIKEAFPQLKVLADLKIMDAGGYEIMKASEAGADIITVLGATDDATIKGAVEEAKKQ KKKILVDMINVKDIESRAKEIDALGVDYICVHTGYDLQAEGKNSFEELTTIKNTVKNA KTAIAGGIKLDTLPEVIQQKPDLVIVGGGITSAADKAETASKMKQLIVQG*" /label="hxlA CDS" gene complement(356733..357365) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /label="hxlA gene" promotor_-10 complement(357391..357410) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(357406) /Source="Nicolas_upshifts" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(357425..357428) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 357489..357492 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 357507..357526 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 357513 /Source="Nicolas_upshifts" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="upshifts" CDS 357599..357961 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15978081, 26973631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15978081, 26973631; Product type r: regulator" /codon_start=1 /transl_table=11 /product="positive regulator of hxlAB expression (formaldehyde sensing)" /protein_id="NP_388229.2" /db_xref="EnsemblGenomes-Gn:BSU03470" /db_xref="EnsemblGenomes-Tr:CAB12141" /db_xref="GOA:P42406" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11184" /db_xref="UniProtKB/Swiss-Prot:P42406" /translation="MSRMDDKRFNCEKELTLAVIGGKWKMLILWHLGKEGTKRFNELK TLIPDITQKILVNQLRELEQDMIVHREVYPVVPPKVEYSLTPHGESLMPILEAMYEWG KGYMELIDIDKNVMKESL*" /label="hxlR CDS" gene 357599..357961 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /label="hxlR gene" downshifts 357945 /Source="Nicolas_upshifts" /id="D153" /incds=0 /nref=14 /ntot=154 /MaxReadThrough="3.13609" /MaxDrop="3.66949" /score="20.4643411" /energy="-9.6" /TU="U267" /idTUdmin="U263" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 358208..358211 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 358226..358245 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 358234..358534 /Source="Nicolas_S_feature" /locus_tag="new_376667_376967" /HighExp="HiOs, T-1.10H, T5.0H, T4.0H, T-1.40H, S2, M9-stat, T3.30H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.20585600000000001" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S126" upshifts 358234 /Source="Nicolas_upshifts" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="upshifts" CDS 358535..369298 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388230.2" /db_xref="EnsemblGenomes-Gn:BSU03480" /db_xref="EnsemblGenomes-Tr:CAB12142" /db_xref="GOA:P27206" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013321" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10168" /db_xref="UniProtKB/Swiss-Prot:P27206" /translation="MEITFYPLTDAQKRIWYTEKFYPHTSISNLAGIGKLVSADAIDY VLVEQAIQEFIRRNDAMRLRLRLDENGEPVQYISEYRPVDIKHTDTTEDPNAIEFISQ WSREETKKPLPLYDCDLFRFSLFTIKENEVWFYANVHHVISDGISMNILGNAIMHIYL ELASGSETKEGISHSFIDHVLSEQEYAQSKRFEKDKAFWNKQFESVPELVSLKRNASA GGSLDAERFSKDVPEALHQQILSFCEANKVSVLSVFQSLLAAYLYRVSGQNDVVTGTF MGNRTNAKEKQMLGMFVSTVPLRTNIDGGQAFSEFVKDRMKDLMKTLRHQKYPYNLLI NDLRETKSSLTKLFTVSLEYQVMQWQKEEDLAFLTEPIFSGSGLNDVSIHVKDRWDTG KLTIDFDYRTDLFSREEINMICERMITMLENALTHPEHTIDELTLISDAEKEKLLARA GGKSVSYRKDMTIPELFQEKAELLSDHPAVVFEDRTLSYRTLHEQSARIANVLKQKGV GPDSPVAVLIERSERMITAIMGILKAGGAYVPIDPGFPAERIQYILEDCGADFILTES KVAAPEADAELIDLDQAIEEGAEESLNADVNARNLAYIIYTSGTTGRPKGVMIEHRQV HHLVESLQQTIYQSGSQTLRMALLAPFHFDASVKQIFASLLLGQTLYIVPKKTVTNGA ALTAYYRKNSIEATDGTPAHLQMLAAAGDFEGLKLKHMLIGGEGLSSVVADKLLKLFK EAGTAPRLTNVYGPTETCVDASVHPVIPENAVQSAYVPIGKALGNNRLYILDQKGRLQ PEGVAGELYIAGDGVGRGYLHLPELTEEKFLQDPFVPGDRMYRTGDVVRWLPDGTIEY LGREDDQVKVRGYRIELGEIEAVIQQAPDVAKAVVLARPDEQGNLEVCAYVVQKPGSE FAPAGLREHAARQLPDYMVPAYFTEVTEIPLTPSGKVDRRKLFALEVKAVSGTAYTAP RNETEKAIAAIWQDVLNVEKAGIFDNFFETGGHSLKAMTLLTKIHKETGIEIPLQFLF EHPTITALAEEADHRESKAFAVIEPAEKQEHYPLSLAQQRTYIVSQFEDAGVGYNMPA AAILEGPLDIQKLERAFQGLIRRHESLRTSFVLENSTPRQKIHDSVDFNIEMIERGGR SDEAIMASFVRTFDLAKAPLFRIGLLGLEENRHMLLFDMHHLISDGVSIGIMLEELAR IYKGEQLPDLRLQYKDYAVWQSRQAAEGYKKDQAYWKEVFAGELPVLQLLSDYPRPPV QSFEGDRVSIKLDAGVKDRLNRLAEQNGATLYMVMLSAYYTLLSKYTGQDDIIVGTPS AGRNHSDTEGIIGMFVNTLAIRSEVKQNETFTQLISRVRKRVLDAFSHQDYPFEWLVE DLNIPRDVSRHPLFDTMFSLQNATEGIPAVGDLSLSVQETNFKIAKFDLTVQARETDE GIEIDVDYSTKLFKQSTADRLLTHFARLLEDAAADPEKPISEYKLLSEEEAASQIQQF NPGRTPYPKDKTIVQLFEEQAANTPDHTALQYEGESLTYRELNERANRLARGILSLGA GEGRTAAVLCERSMDMIVSILAVLKSGSAYVPIDPEHPIQRMQHFFRDSGAKVLLTQR KLKALAEEAEFKGVIVLADEEESYHADARNLALPLDSAAMANLTYTSGTTGTPKGNIV THANILRTVKETNYLSITEQDTILGLSNYVFDAFMFDMFGSLLNGAKLVLIPKETVLD MARLSRVIERENISILMITTALFHLLVDLNPACLSTLRKIMFGGERASVEHVRKALQT VGKGKLLHMYGPSESTVFATYHPVDELEEHTLSVPIGKPVSNTEVYILDRTGHVQPAG IAGELCVSGEGLVKGYYNRPELTEEKFVPHPFTSGERMYKTGDLARWLPNGDIEFIGR IDHQVKIRGQRIELGEIEHQLQTHDRVQESVVLAVDQGAGDKLLCAYYVGEGDISSQE MREHAAKDLPAYMVPAVFIQMDELPLTGNGKIDRRALPIPDANVSRGVSYVAPRNGTE QKVADIWAQVLQAEQVGAYDHFFDIGGHSLAGMKMLALVHQELGVELSLKDLFQSPTV EGLAQVIASAEKGTAASISPAEKQDTYPVSSPQKRMYVLQQLEDAQTSYNMPAVLRLT GELDVERLNSVMQQLMQRHEALRTTFEIKDGETVQRIWEEAECEIAYFEAPEEETERI VSEFIKPFKIDQLPLFRIGLIKHSDTEHVLLFDMHHIISDGASVGVLIEELSKLYDGE TLEPLRIQYKDYAVWQQQFIQSELYKKQEEHWLKELDGELPVLTLPTDYSRPAVQTFE GDRIAFSLEAGKADALRRLAKETDSTLYMVLLASYSAFLSKISGQDDIIVGSPVAGRS QADVSRVIGMFVNTLALRTYPKGEKTFADYLNEVKETALSAFDAQDYPLEDLIGNVQV QRDTSRNPLFDAVFSMQNANIKDLTMKGIQLEPHPFERKTAKFDLTLTADETDGGLTF VLEYNTALFKQETIERWKQYWMELLDAVTGNPNQPLSSLSLVTETEKQALLEAWKGKA LPVPTDKTVHQLFEETAQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDD RVGVLTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISV PDSYTGDVILLDGSRTILSLPLDENDEENPETAVTAENLAYMIYTSGTTGQPKGVMVE HHALVNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIEEAIRLD IVRLNDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNY GPTENTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLA RGYLNREDETAKRFVADPFVPGERMYRTGDLVKWTGGGIEYIGRIDQQVKVRGYRIEL SEIEVQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPESADIEALKSALKETLPDYMIP AFWVTLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEV GVTDNFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQ GPVEGEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDAL RMVYREGQEDVIQYNRGLEAASAQLEVIQIEGQAADYEDRIEREAERLQSSIDLQEGG LLKAGLFQAEDGDHLLLAIHHLVVDGVSWRILLEDFAAVYTQLEQGNEPVLPQKTHSF AEYAERLQDFANSKAFLKEKEYWRQLEEQAVAAKLPKDRESGDQRMKHTKTIEFSLTA EETEQLTTKVHEAYHTEMNDILLTAFGLAMKEWTGQDRVSVHLEGHGREEIIEDLTIS RTVGWFTSMYPMVLDMKHADDLGYQLKQMKEDIRHVPNKGVGYGILRYLTAPEHKEDV AFSIQPDVSFNYLGQFDEMSDAGLFTRSELPSGQSLSPETEKPNALDVVGYIENGKLT MSLAYHSLEFHEKTVQTFSDSFKAHLLRIIEHCLSQDGTELTPSDLGDDDLTLDELDK LMEIF*" /label="srfAA CDS" gene 358535..369298 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /label="srfAA gene" CDS 369311..380062 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388231.2" /db_xref="EnsemblGenomes-Gn:BSU03490" /db_xref="EnsemblGenomes-Tr:CAB12143" /db_xref="GOA:Q04747" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10169" /db_xref="UniProtKB/Swiss-Prot:Q04747" /translation="MSKKSIQKVYALTPMQEGMLYHAMLDPHSSSYFTQLELGIHGAF DLEIFEKSVNELIRSYDILRTVFVHQQLQKPRQVVLAERKTKVHYEDISHADENRQKE HIERYKQDVQRQGFNLAKDILFKVAVFRLAADQLYLVWSNHHIMMDGWSMGVLMKSLF QNYEALRAGRTPANGQGKPYSDYIKWLGKQDNEEAESYWSERLAGFEQPSVLPGRLPV KKDEYVNKEYSFTWDETLVARIQQTANLHQVTGPNLFQAVWGIVLSKYNFTDDVIFGT VVSGRPSEINGIETMAGLFINTIPVRVKVERDAAFADIFTAVQQHAVEAERYDYVPLY EIQKRSALDGNLLNHLVAFENYPLDQELENGSMEDRLGFSIKVESAFEQTSFDFNLIV YPGKTWTVKIKYNGAAFDSAFIERTAEHLTRMMEAAVDQPAAFVREYGLVGDEEQRQI VEVFNSTKAELPEGMAVHQVFEEQAKRTPASTAVVYEGTKLTYRELNAAANRLARKLV EHGLQKGETAAIMNDRSVETVVGMLAVLKAGAAYVPLDPALPGDRLRFMAEDSSVRMV LIGNSYTGQAHQLQVPVLTLDIGFEESEAADNLNLPSAPSDLAYIMYTSGSTGKPKGV MIEHKSILRLVKNAGYVPVTEEDRMAQTGAVSFDAGTFEVFGALLNGAALYPVKKETL LDAKQFAAFLREQSITTMWLTSPLFNQLAAKDAGMFGTLRHLIIGGDALVPHIVSKVK QASPSLSLWNGYGPTENTTFSTSFLIDREYGGSIPIGKPIGNSTAYIMDEQQCLQPIG APGELCVGGIGVARGYVNLPELTEKQFLEDPFRPGERIYRTGDLARWLPDGNIEFLGR IDNQVKVRGFRIELGEIETKLNMAEHVTEAAVIIRKNKADENEICAYFTADREVAVSE LRKTLSQSLPDYMVPAHLIQMDSLPLTPNGKINKKELPAPQSEAVQPEYAAPKTESEK KLAEIWEGILGVKAGVTDNFFMIGGHSLKAMMMTAKIQEHFHKEVPIKVLFEKPTIQE LALYLEENESKEEQTFEPIRQASYQQHYPVSPAQRRMYILNQLGQANTSYNVPAVLLL EGEVDKDRLENAIQQLINRHEILRTSFDMIDGEVVQTVHKNISFQLEAAKGREEDAEE IIKAFVQPFELNRAPLVRSKLVQLEEKRHLLLIDMHHIITDGSSTGILIGDLAKIYQG ADLELPQIHYKDYAVWHKEQTNYQKDEEYWLDVFKGELPILDLPADFERPAERSFAGE RVMFGLDKQITAQIKSLMAETDTTMYMFLLAAFNVLLSKYASQDDIIVGSPTAGRTHP DLQGVPGMFVNTVALRTAPAGDKTFAQFLEEVKTASLQAFEHQSYPLEELIEKLPLTR DTSRSPLFSVMFNMQNMEIPSLRLGDLKISSYSMLHHVAKFDLSLEAVEREEDIGLSF DYATALFKDETIRRWSRHFVNIIKAAAANPNVRLSDVDLLSSAETAALLEERHMTQIT EATFAALFEKQAQQTPDHSAVKAGGNLLTYRELDEQANQLAHHLRAQGAGNEDIVAIV MDRSAEVMVSILGVMKAGAAFLPIDPDTPEERIRYSLEDSGAKFAVVNERNMTAIGQY EGIIVSLDDGKWRNESKERPSSISGSRNLAYVIYTSGTTGKPKGVQIEHRNLTNYVSW FSEEAGLTENDKTVLLSSYAFDLGYTSMFPVLLGGGELHIVQKETYTAPDEIAHYIKE HGITYIKLTPSLFHTIVNTASFAKDANFESLRLIVLGGEKIIPTDVIAFRKMYGHTEF INHYGPTEATIGAIAGRVDLYEPDAFAKRPTIGRPIANAGALVLNEALKLVPPGASGQ LYITGQGLARGYLNRPQLTAERFVENPYSPGSLMYKTGDVVRRLSDGTLAFIGRADDQ VKIRGYRIEPKEIETVMLSLSGIQEAVVLAVSEGGLQELCAYYTSDQDIEKAELRYQL SLTLPSHMIPAFFVQVDAIPLTANGKTDRNALPKPNAAQSGGKALAAPETALEESLCR IWQKTLGIEAIGIDDNFFDLGGHSLKGMMLIANIQAELEKSVPLKALFEQPTVRQLAA YMEASAVSGGHQVLKPADKQDMYPLSSAQKRMYVLNQLDRQTISYNMPSVLLMEGELD ISRLRDSLNQLVNRHESLRTSFMEANGEPVQRIIEKAEVDLHVFEAKEDEADQKIKEF IRPFDLNDAPLIRAALLRIEAKKHLLLLDMHHIIADGVSRGIFVKELALLYKGEQLPE PTLHYKDFAVWQNEAEQKERMKEHEAYWMSVLSGELPELDLPLDYARPPVQSFKGDTI RFRTGSETAKAVEKLLAETGTTLHMVLHAVFHVFLSKISGQRDIVIGSVTAGRTNADV QDMPGMFVNTLALRMEAKEQQTFAELLELAKQTNLSALEHQEYPFEDLVNQLDLPRDM SRNPLFNVMVTTENPDKEQLTLQNLSISPYEAHQGTSKFDLTLGGFTDENGIGLQLEY ATDLFAKETAEKWSEYVLRLLKAVADNPNQPLSSLLLVTETEKQALLEAWKGKALPVP TDKTVHQLFEETVQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDDRVGV LTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISVPDSY TGDVILLDGSRTILSLPLDENDEGNPETAVTAENLAYMIYTSGTTGQPKGVMVEHHAL VNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIDEAIRLDIVRL NDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNYGPTE NTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLARGYL NREDETAKRFVADPFVPGERMYRTGDLVKWVNGGIEYIGRIDQQVKVRGYRIELSEIE VQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPETADIEALKSTLKETLPDYMIPAFWV TLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEVGVTD NFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQGPVE GEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDALRMVY REENGDIVQVYKPIGESKVSFEIVDLYGSDEEMLRSQIKLLANKLQSSLDLRNGPLLK AEQYRTEAGDHLLIAVHHLVVDGVSWRILLEDFASGYMQAEKEESLVFPQKTNSFKDW AEELAAFSQSAHLLQQAEYWSQIAAEQVSPLPKDCETEQRIVKDTSSVLCELTAEDTK HLLTDVHQPYGTEINDILLSALGLTMKEWTKGAKIGINLEGHGREDIIPNVNISRTVG WFTAQYPVVLDISDADASAVIKTVKENLRRIPDKGVGYGILRYFTETAETKGFTPEIS FNYLGQFDSEVKTDFFEPSAFDMGRQVSGESEALYALSFSGMIRNGRFVLSCSYNEKE FERATVEEQMERFKENLLMLIRHCTEKEDKEFTPSDFSAEDLEMDEMGDIFDMLEENL K*" /label="srfAB CDS" gene 369311..380062 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /label="srfAB gene" CDS 372447..372587 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10361283, 16554821, 8752331, 9696775, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 16554821, 8752331, 9696775, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of genetic competence" /protein_id="NP_388232.1" /db_xref="EnsemblGenomes-Gn:BSU03500" /db_xref="EnsemblGenomes-Tr:CAB12144" /db_xref="GOA:P80355" /db_xref="InterPro:IPR035139" /db_xref="SubtiList:BG11045" /db_xref="UniProtKB/Swiss-Prot:P80355" /translation="MNRSGKHLISSIILYPRPSGECISSISLDKQTQATTSPLYFCWR EK*" /label="comS CDS" gene 372447..372587 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /label="comS gene" CDS 380099..383926 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388233.2" /db_xref="EnsemblGenomes-Gn:BSU03510" /db_xref="EnsemblGenomes-Tr:CAB12145" /db_xref="GOA:Q08787" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="PDB:1JMK" /db_xref="PDB:2VSQ" /db_xref="SubtiList:BG10170" /db_xref="UniProtKB/Swiss-Prot:Q08787" /translation="MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVK GSLNIKCLEESMNVIMDRYDVFRTVFIHEKVKRPVQVVLKKRQFHIEEIDLTHLTGSE QTAKINEYKEQDKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQ DLFKVYNALREQKPYSLPPVKPYKDYIKWLEKQDKQASLRYWREYLEGFEGQTTFAEQ RKKQKDGYEPKELLFSLSEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLA FGTVVSGRPAEIKGVEHMVGLFINVVPRRVKLSEGITFNGLLKRLQEQSLQSEPHQYV PLYDIQSQADQPKLIDHIIVFENYPLQDAKNEESSENGFDMVDVHVFEKSNYDLNLMA SPGDEMLIKLAYNENVFDEAFILRLKSQLLTAIQQLIQNPDQPVSTINLVDDREREFL LTGLNPPAQAHETKPLTYWFKEAVNANPDAPALTYSGQTLSYRELDEEANRIARRLQK HGAGKGSVVALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLL THQEMKEQAAELPYTGTTLFIDDQTRFEEQASDPATAIDPNDPAYIMYTSGTTGKPKG NITTHANIQGLVKHVDYMAFSDQDTFLSVSNYAFDAFTFDFYASMLNAARLIIADEHT LLDTERLTDLILQENVNVMFATTALFNLLTDAGEDWMKGLRCILFGGERASVPHVRKA LRIMGPGKLINCYGPTEGTVFATAHVVHDLPDSISSLPIGKPISNASVYILNEQSQLQ PFGAVGELCISGMGVSKGYVNRADLTKEKFIENPFKPGETLYRTGDLARWLPDGTIEY AGRIDDQVKIRGHRIELEEIEKQLQEYPGVKDAVVVADRHESGDASINAYLVNRTQLS AEDVKAHLKKQLPAYMVPQTFTFLDELPLTTNGKVNKRLLPKPDQDQLAEEWIGPRNE MEETIAQIWSEVLGRKQIGIHDDFFALGGHSLKAMTAASRIKKELGIDLPVKLLFEAP TIAGISAYLKNGGSDGLQDVTIMNQDQEQIIFAFPPVLGYGLMYQNLSSRLPSYKLCA FDFIEEEDRLDRYADLIQKLQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMV DSYKKQGVSDLDGRTVESDVEALMNVNRDNEALNSEAVKHGLKQKTHAFYSYYVNLIS TGQVKADIDLLTSGADFDMPEWLASWEEATTGVYRVKRGFGTHAEMLQGETLDRNAEI LLEFLNTQTVTVS*" /label="srfAC CDS" gene 380099..383926 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /label="srfAC gene" CDS 383955..384683 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388234.1" /db_xref="EnsemblGenomes-Gn:BSU03520" /db_xref="EnsemblGenomes-Tr:CAB12146" /db_xref="GOA:Q08788" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR012223" /db_xref="InterPro:IPR029058" /db_xref="PDB:2K2Q" /db_xref="PDB:2RON" /db_xref="SubtiList:BG10171" /db_xref="UniProtKB/Swiss-Prot:Q08788" /translation="MSQLFKSFDASEKTQLICFPFAGGYSASFRPLHAFLQGECEMLA AEPPGHGTNQTSAIEDLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLERE GIFPQAVIISAIQPPHIQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSF RSDYRALEQFELYDLAQIQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMF LLSQTEEVAERIFAILNQHPIIQP*" /label="srfAD CDS" gene 383955..384683 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /label="srfAD gene" downshifts 384665 /Source="Nicolas_upshifts" /id="D154" /incds=0 /nref=196 /ntot=261 /MaxReadThrough="4.65721" /MaxDrop="6.48992" /score="24.9581454" /energy="-11.1" /TU="U268" /idTUdmin="U268" /TUdmin="-1339" /isTUend="FALSE" /label="downshifts" promotor_-35 384721..384728 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 384731 /Source="Nicolas_upshifts" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 384740..384759 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 384784..386010 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15849754, 16850406, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter" /protein_id="NP_388235.2" /db_xref="EnsemblGenomes-Gn:BSU03530" /db_xref="EnsemblGenomes-Tr:CAB12147" /db_xref="GOA:Q08791" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10172" /db_xref="UniProtKB/Swiss-Prot:Q08791" /translation="MRTSPRMKWFVLLFTFVFAIGMNSFRNSFQFFMLPMADAFHADR SLISVSVSIFMITTGIVQFFVGFFIDRFSVRKIMALGAVCISASFLVLPYSPNVHVFS AIYGVLGGIGYSCAVGVTTQYFISCWFDTHKGLALAILTNANSAGLLLLSPIWAAAPY HAGWQSTYTILGIVMAAVLLPLLVFGMKHPPHAQAETVKKSYDWRGFWNVMKQSRLIH ILYFGVFTCGFTMGIIDAHLVPILKDAHVSHVNGMMAAFGAFIIIGGLLAGWLSDLLG SRSVMLSILFFIRLLSLICLLIPILGIHHSDLWYFGFILLFGLSYTGVIPLTAASISE SYQTGLIGSLLGINFFIHQVAGALSVYAGGLFFDMTHGYLLIVAVCIVFVGLSAVIEL VPFLDKQKAKETHHSI*" /label="srfT CDS" gene 384784..386010 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /label="srfT gene" downshifts 386004 /Source="Nicolas_upshifts" /id="D155" /incds=0 /nref=15 /ntot=198 /MaxReadThrough="2.67601" /MaxDrop="4.06773" /score="7.33278866" /energy="-13.2" /TU="NA" /idTUdmin="U268" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(386025..386582) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 21965396" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388236.1" /db_xref="EnsemblGenomes-Gn:BSU03540" /db_xref="EnsemblGenomes-Tr:CAB12148" /db_xref="GOA:Q08793" /db_xref="InterPro:IPR025588" /db_xref="SubtiList:BG10173" /db_xref="UniProtKB/Swiss-Prot:Q08793" /translation="MIQYASESINLPGEITFKDVREIFFYQIAKISCFYFLLFCAIFA AVNFINGWPRIVYGSDALNLFMNSMLIIVMSVLFTLLLLLLLYVKFSRAYKKNERMKS KRTYTLNQEGIRICSKKYDLIFNWDEITAVFEYKNIFRVNTSSGQYIAIPKHFFHSEE EMNRFKEIILKNTETKKLKFKKDQH*" /label="ycxB CDS" gene complement(386025..386582) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /label="ycxB gene" promotor_no_box complement(386040..386140) /Source="Nicolas_upshift_promotors" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts complement(386062) /Source="Nicolas_upshifts" /id="D156" /incds=0 /nref=46 /ntot=241 /MaxReadThrough="0.9216" /MaxDrop="4.25654" /score="8.42655219" /energy="-14.3" /TU="U270" /idTUdmin="U271" /TUdmin=18 /isTUend="TRUE" /label="downshifts" upshifts complement(386080) /Source="Nicolas_upshifts" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(386611..386630) /Source="Nicolas_upshift_promotors" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(386613) /Source="Nicolas_upshifts" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(386636..387574) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388237.2" /db_xref="EnsemblGenomes-Gn:BSU03550" /db_xref="EnsemblGenomes-Tr:CAB12149" /db_xref="GOA:Q08794" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10174" /db_xref="UniProtKB/Swiss-Prot:Q08794" /translation="MVKHQQTPAYIAAILYSFIIGLSFLFVKIALQTAEPFDILAHRF TIAFAAATVPILFGWVKLSIRVKDVIDILPLALLYPALFFSFQAFGLVYSSSSEAGII QAAIPIFTMVFAAYVLKERPTWTQKGFTVLSVAGVMFIFVMKGVDVESASLKGSLLIL LSALSSAMYNTAARKMTQRFKLTELTYIMSAIGFVVFNAIALVRHGAAGTVGTYFLPF REPGFVLAIVYLGVLSSLVTSFLSNYTLSRIEAFKMSAFNHVSTIVTMIAGFVILNES LAWYHLAGAVCIMIGVVGSNINLEKKTKRPGMPAKK*" /label="ycxC CDS" gene complement(386636..387574) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /label="ycxC gene" promotor_-10 complement(387613..387631) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(387620) /Source="Nicolas_upshifts" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(387647..387652) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 387698..389032 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 26585522; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388238.1" /db_xref="EnsemblGenomes-Gn:BSU03560" /db_xref="EnsemblGenomes-Tr:CAB12150" /db_xref="GOA:Q08792" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10175" /db_xref="UniProtKB/Swiss-Prot:Q08792" /translation="MEKYMSLLTRIEEMMQSTSYQEGDRLPSIRQLSARYQVSKSTVI RALQELEKRHLIYSVPKSGYYIVKKSGKSKSGQPGPIDFATSAPDPDVFPYLDFQHCI NKAIDTYKNDLFIYGTPKGLPSLIRVLRKLLATQQVFADERHIFITSGVQQALSLLCA MPFPNGKEKIAIEQPGYHLMVEQLETLGIPAIGVKRTEEGLDIAKVERLFQTESIKFF YTMPRFHNPLGCSLSERDKQELVRLAEAYDVYLVEDDYLGDLEENKKADPLYAYDLSS HVIYLKSFSKMMFPGLRVGAAVLPEALTDTFYAYKKLNDIDCSMISQAALEIYLKSGM YGRHKEKIRDSYKERSLRLHQAIRTHRQLGSGRFTFSSGQAPCMHTHLVLPQDLPASR VIHRLEKQGVLLEAIDRHYLSDYPKENLLKINISNVKTEDIERGVKLLMSHL*" /label="ycxD CDS" gene 387698..389032 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /label="ycxD gene" CDS complement(389027..389194) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="C-terminal part of 4'-phosphopantetheinyl transferase (Surfactin synthetase-activating enzyme)" /db_xref="PSEUDO:CAX52545.1" /translation="MRLHQDGQVSIELPDSHSPCYIKTYEVDPGYKMAVCAVHPDFPE DITMVSYEELL*" /label="sfpAc CDS" gene complement(389027..389194) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /pseudo /label="sfpAc gene" CDS complement(389205..389702) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="N-terminal part of 4'-phosphopantetheinyl transferase (surfactin synthetase-activating enzyme)" /db_xref="GOA:P39135" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1QR0" /db_xref="PDB:2GE0" /db_xref="PDB:2GE1" /db_xref="PDB:4MRT" /db_xref="PSEUDO:CAB12151.2" /db_xref="SubtiList:BG10176" /db_xref="UniProtKB/Swiss-Prot:P39135" /translation="MKIYGIYMDRPLSQEENERFMSFISPEKREKCRRFYHKEDAHRT LLGDVLVRSVISRQYQLDKSDIRFSTQEYGKPCIPDLPDAHFNISHSGRWVICAFDSQ PIGIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWSMKESFIKQGRQR LIASA*" /label="sfpAn CDS" gene complement(389205..389702) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /pseudo /label="sfpAn gene" misc_feature complement(389729..389748) /Source="Nicolas_upshift_promotors" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(389741) /Source="Nicolas_upshifts" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="upshifts" CDS complement(389807..390454) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /function="15.11: Biosynthesis of natural products" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17827323, 14762003, 16707694, 17827323, 25288929; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein regulating antibiotic production" /protein_id="NP_388240.2" /db_xref="EnsemblGenomes-Gn:BSU03580" /db_xref="EnsemblGenomes-Tr:CAB12152" /db_xref="GOA:O34927" /db_xref="SubtiList:BG12779" /db_xref="UniProtKB/Swiss-Prot:O34927" /translation="MKQELVLRWTFYFAGLIILAFGVSLTIEGKALGISPWDAFHYSL FQHFGLTVGQWSIIIGALIVGFTSLFTRAWPKIGALLNMVLIGVFIDFFNFILPALST YTGSIIVFSLGVVLIGYGVGVYVSAGLGAGPRDSLMMLITEKTGWNVQWVRNGMELTI LFAAWGMGGPIGFGTILTAILTGLILRFSLPQSIQLLNYAVARRTAAVKASPPVH*" /label="yczE CDS" gene complement(389807..390454) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /label="yczE gene" promotor_-10 complement(390483..390502) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(390486) /Source="Nicolas_upshifts" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(390518..390522) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(390623..390774) /Source="Nicolas_S_feature" /locus_tag="new_409056_409207_c" /HighExp="G180, G135, dia15, H2O2, Diami, S8, Oxctl, G150, LPhT, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S127" CDS complement(390775..391518) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 16513748, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 16513748, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (ATP-binding protein)" /protein_id="NP_388241.2" /db_xref="EnsemblGenomes-Gn:BSU03590" /db_xref="EnsemblGenomes-Tr:CAB12153" /db_xref="GOA:P39456" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11185" /db_xref="UniProtKB/Swiss-Prot:P39456" /translation="MLTVKGLNKSFGENEILKKIDMKIEKGKVIAILGPSGSGKTTLL RCLNALEIPNRGELAFDDFSIDFSKKVKQADILKLRRKSGMVFQAYHLFPHRTALENV MEGPVQVQKRNKEEVRKEAIQLLDKVGLKDKMDLYPFQLSGGQQQRVGIARALAIQPE LMLFDEPTSALDPELVGEVLKVIKDLANEGWTMVVVTHEIKFAQEVADEVIFIDGGVI VEQGPPEQIFSAPKEERTQRFLNRILNPL*" /label="tcyC CDS" gene complement(390775..391518) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /label="tcyC gene" downshifts complement(390831) /Source="Nicolas_upshifts" /id="D157" /incds=0 /nref=72 /ntot=232 /MaxReadThrough="4.60958" /MaxDrop="4.44283" /score="1.62131565" /energy="-12.6" /TU="U275" /idTUdmin="U276" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(391532..392236) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 15849754, 16850406, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 15849754, 16850406, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (permease)" /protein_id="NP_388242.1" /db_xref="EnsemblGenomes-Gn:BSU03600" /db_xref="EnsemblGenomes-Tr:CAB12154" /db_xref="GOA:P42200" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11186" /db_xref="UniProtKB/Swiss-Prot:P42200" /translation="MFLNNLPALTLGTAIPWDLVQQSFWPILSGGIYYTIPLTILSFI FGMILALITALARMSKVRPLRWVFSVYVSAIRGTPLLVQLFIIFYLFPAFNVTLDPFP SAVIAFSLNVGAYASEIIRASILSVPKGQWEAGYTIGMTHQKTLFRVILPQAFRVSIP PLSNTFISLIKDTSLASQILVAELFRKAQEIGARNLDQILVIYIEAAFIYWIICFLLS LVQHVIERRLDRYVAK*" /label="tcyB CDS" gene complement(391532..392236) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /label="tcyB gene" CDS complement(392223..393029) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (substrate-binding lipoprotein)" /protein_id="NP_388243.2" /db_xref="EnsemblGenomes-Gn:BSU03610" /db_xref="EnsemblGenomes-Tr:CAB12155" /db_xref="GOA:P42199" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11187" /db_xref="UniProtKB/Swiss-Prot:P42199" /translation="MKKALLALFMVVSIAALAACGAGNDNQSKDNAKDGDLWASIKKK GVLTVGTEGTYEPFTYHDKDTDKLTGYDVEVITEVAKRLGLKVDFKETQWDSMFAGLN SKRFDVVANQVGKTDREDKYDFSDKYTTSRAVVVTKKDNNDIKSEADVKGKTSAQSLT SNYNKLATNAGAKVEGVEGMAQALQMIQQGRVDMTYNDKLAVLNYLKTSGNKNVKIAF ETGEPQSTYFTFRKGSGEVVDQVNKALKEMKEDGTLSKISKKWFGEDVSK*" /label="tcyA CDS" gene complement(392223..393029) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /label="tcyA gene" promotor_-10 complement(393078..393097) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(393090) /Source="Nicolas_upshifts" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(393111..393118) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(393145..394017) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17295427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17295427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="HTH-type transcriptional regulator BsdA (LysR family)" /protein_id="NP_388244.1" /db_xref="EnsemblGenomes-Gn:BSU03620" /db_xref="EnsemblGenomes-Tr:CAB12156" /db_xref="GOA:P94403" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12022" /db_xref="UniProtKB/Swiss-Prot:P94403" /translation="MDIRQLRYFITIAQEQKITSAAKKLHMAQPPLSRQLKQLEDELG VVLFDRNKKKQMTLTYEGAVFLKRAKEILHRFEDAVIEVQELKEEVAGTLAVGSTIYC AALMLEKVTQIKERYPHLTFNIWENEPATLLELLESRQIDAAVTTTLIKSDTVQFKQL DDIPCVLVLSDEAGYPCGDTIKMVDIPSFPLILLRPVNGKGVYNQVMNEFHRLNLEPR IVCECHDSATLLSLVSSGFGASILPVTMIPVHMRNHVHTVHIENNPFIMTPAVMWRTD SYLPKPAQQFLDLF*" /label="bsdA CDS" gene complement(393145..394017) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /label="bsdA gene" promotor_-10 complement(393755..393773) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(393762) /Source="Nicolas_upshifts" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(393788..393794) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 394071..394078 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(394086..394105) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-10" promotor_-10 394092..394111 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(394092) /Source="Nicolas_upshifts" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="upshifts" upshifts 394100 /Source="Nicolas_upshifts" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="upshifts" CDS 394107..394721 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10919793, 15979273, 17295427, 18388975, 26083743, 26658822, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase-flavin prenyltransferase subunit" /protein_id="NP_388245.1" /db_xref="EnsemblGenomes-Gn:BSU03630" /db_xref="EnsemblGenomes-Tr:CAB12157" /db_xref="GOA:P94404" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR004507" /db_xref="InterPro:IPR032901" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG12023" /db_xref="UniProtKB/Swiss-Prot:P94404" /translation="MKAEFKRKGGGKVKLVVGMTGATGAIFGVRLLQWLKAAGVETHL VVSPWANVTIKHETGYTLQEVEQLATYTYSHKDQAAAISSGSFDTDGMIVAPCSMKSL ASIRTGMADNLLTRAADVMLKERKKLVLLTRETPLNQIHLENMLALTKMGTIILPPMP AFYNRPRSLEEMVDHIVFRTLDQFGIRLPEAKRWNGIEKQKGGA*" /label="ubiX CDS" gene 394107..394721 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /label="ubiX gene" promotor_-35 complement(394119..394126) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-35" CDS 394724..396145 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /EC_number="4.1.1.61" /EC_number="4.1.1.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11029449, 15979273, 17295427, 18388975, 26658822, 26337367; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phenolic acid decarboxylase subunit;1,4-dihydroxy-2-naphtoate-heptaprenyl diphosphatedecarboxylase" /protein_id="NP_388246.1" /db_xref="EnsemblGenomes-Gn:BSU03640" /db_xref="EnsemblGenomes-Tr:CAB12158" /db_xref="GOA:P94405" /db_xref="InterPro:IPR002830" /db_xref="InterPro:IPR012349" /db_xref="InterPro:IPR032902" /db_xref="SubtiList:BG12024" /db_xref="UniProtKB/Swiss-Prot:P94405" /translation="MAYQDFREFLAALEKEGQLLTVNEEVKPEPDLGASARAASNLGD KSPALLFNNIYGYHNARIAMNVIGSWPNHAMMLGMPKDTPVKEQFFEFAKRYDQFPMP VKREETAPFHENEITEDINLFDILPLFRINQGDGGYYLDKACVISRDLEDPDNFGKQN VGIYRMQVKGKDRLGIQPVPQHDIAIHLRQAEERGINLPVTIALGCEPVITTAASTPL LYDQSEYEMAGAIQGEPYRIVKSKLSDLDVPWGAEVVLEGEIIAGEREYEGPFGEFTG HYSGGRSMPIIKIKRVYHRNNPIFEHLYLGMPWTECDYMIGINTCVPLYQQLKEAYPN EIVAVNAMYTHGLIAIVSTKTRYGGFAKAVGMRALTTPHGLGYCKMVIVVDEDVDPFN LPQVMWALSTKMHPKHDAVIIPDLSVLPLDPGSNPSGITHKMILDATTPVAPETRGHY SQPLDSPLTTKEWEQKLMDLMNK*" /label="bsdC CDS" gene 394724..396145 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /label="bsdC gene" CDS 396162..396389 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /EC_number="4.1.1.91" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15979273, 17295427, 18388975, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase subunit" /protein_id="YP_003097675.1" /db_xref="EnsemblGenomes-Gn:BSU03651" /db_xref="EnsemblGenomes-Tr:CAX52546" /db_xref="GOA:C0H3U9" /db_xref="UniProtKB/Swiss-Prot:C0H3U9" /translation="MHTCPRCDSKKGEVMSKSPVEGAWEVYQCQTCFFTWRSCEPESI TNPEKYNPAFKIDPKETETAIEVPAVPERKA*" /label="bsdD CDS" gene 396162..396389 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /label="bsdD gene" CDS 396386..396850 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15979273, 18388975; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN-binding enzyme subunit" /protein_id="NP_388247.2" /db_xref="EnsemblGenomes-Gn:BSU03652" /db_xref="EnsemblGenomes-Tr:CAB12159" /db_xref="GOA:C0SPB5" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12025" /db_xref="UniProtKB/Swiss-Prot:C0SPB5" /translation="MIRVNCMSDRLFELLDGSCLNEKQHEAFVLQTVSEDGWPHAAMI SAGEIIALSRTDIRIALWKNTMTSANILRTGKAQFTAWWKGAAYYVKLECAPLPPLKD AEYERDRFSCRIVSVKEDVAKYADLTSGVRIQLHSPEEVLSRWKKTLEDLKR*" /label="yclD CDS" gene 396386..396850 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /label="yclD gene" downshifts 396831 /Source="Nicolas_upshifts" /id="D158" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="3.32586" /MaxDrop="3.88166" /score="45.8937489" /energy="-15.1" /TU="NA" /idTUdmin="U278" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 396857..396858 /Source="Nicolas_upshift_promotors" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 396858 /Source="Nicolas_upshifts" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 396917..397762 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388248.2" /db_xref="EnsemblGenomes-Gn:BSU03660" /db_xref="EnsemblGenomes-Tr:CAB12160" /db_xref="GOA:P94407" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12026" /db_xref="UniProtKB/Swiss-Prot:P94407" /translation="MERAGICHSDGFDLAYRIEGEGAPILVIGSAVYYPRLFSSDIKQ KYQWVFVDHRGFAKPKRELRAEDSRLDAVLADIERMRTFLQLEDVTILGHSGHAFMAL EYARTYPKQVRKVALFNTAPDNSEERQRKSESFFMETASLERKKRFEKDIENLPQDID KDPERRFVHMCIRAEAKSFYQERPHAAALWDGVFTNMPIIDELWGNTFARIDLLQRLA DVRMPVYIGLGRYDYLVAPVSLWDAVDGLYPHVDKVIFEKSGHQPMLEEPEAFDQSFR KWLDQ*" /label="yclE CDS" gene 396917..397762 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /label="yclE gene" CDS complement(397802..399280) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8458848, 11717292, 15849754, 16204487, 16850406, 17496096, 23144141, 25966844; Product type t: transporter" /codon_start=1 /transl_table=11 /product="di-tripeptide-proton ABC symporter" /protein_id="NP_388249.2" /db_xref="EnsemblGenomes-Gn:BSU03670" /db_xref="EnsemblGenomes-Tr:CAB12175" /db_xref="GOA:P94408" /db_xref="InterPro:IPR000109" /db_xref="InterPro:IPR005279" /db_xref="InterPro:IPR018456" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12027" /db_xref="UniProtKB/Swiss-Prot:P94408" /translation="MASIDNESIIKSVPQKGFFGHPRGLFTLFFTEFWERFSYYGMRA ILLYYLYTETVNGGLGFDKGTAVAIMSIYGSLVYMSTIIGGWLADRVFGTANTVFYGG IFIMFGHIALAYPGSSIAFYISMVLIIVGTGLLKPNVSSVVGDLYTKEDPRRDSGFSI FYMGINLGGLLAPLIVGTLGQKYNYHLGFGAAAVGMLLGLIVFALTRKKNLGLAGSNV PNPLSKKSAIGTGIGVIIVAIAVIISVQTGVLTIKRFIDLVSILGILIPVIYFIIMFT SKKADKTEKSRLAAYVPLFIGAVMFWAIQEQGATILAVYADERIRLSLGGFELQSSWF QSLNPLFVVIFAPIFAWLWMKLGKRQPSTPVKFSIGIILAGLSFIIMVFPAMQGKEAL VSPLWLVLSFLLVVLGELCLSPVGLSVTTKLAPAAFSAQTMSMWFLTNAAAQAINAQV AGLFDKIPETMYFGTIGLISIVLGGILLLLSPVIKRAMKGVL*" /label="dtpT CDS" gene complement(397802..399280) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /label="dtpT gene" downshifts complement(397810) /Source="Nicolas_upshifts" /id="D159" /incds=0 /nref=17 /ntot=90 /MaxReadThrough="1.40624" /MaxDrop="3.91827" /score="43.5753464" /energy="-21" /TU="NA" /idTUdmin="U281" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 399307..399309 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(399308..399327) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 399318 /Source="Nicolas_upshifts" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 399326..399344 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(399328) /Source="Nicolas_upshifts" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(399330..399834) /Source="Nicolas_S_feature" /locus_tag="new_417763_418267_c" /HighExp="S3, S4, LoTm, S5, S6, T5.0H, T4.0H, M9-stat, S8, T3.30H" /AntisenseName="yclG" /AntisenseCor="0.33937447534762299" /AntisenseRegPval="-7.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S128" promotor_-35 complement(399342..399349) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 399498..399507 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 399520..399539 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 399521 /Source="Nicolas_upshifts" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="upshifts" CDS 399560..401314 /gene="yclG" /locus_tag="BSU_03680" /old_locus_tag="BSU03680" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative uronase" /protein_id="NP_388250.1" /db_xref="EnsemblGenomes-Gn:BSU03680" /db_xref="EnsemblGenomes-Tr:CAB12176" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="InterPro:IPR024535" /db_xref="SubtiList:BG12028" /db_xref="UniProtKB/Swiss-Prot:P94409" /translation="MAEFILNAADFGVPRDGKTDSTERINQCLSTAVSKGYHTVWFPK GTYLIDATLGGDLNQRFRNAGIIVPGNLEIMMDPECIMKVIPNSSWGYSAFYVGKQEN ITISGGQIIGERDEHTYASAGIRSTHEWGFGICIEGCSNVVIDDVKISDFTGDGIIVS PRGLKTNQDYRTSEQIIIRRCEVRRSRRNNISITGCDMVTVEECLIEDAGTGNGTAPK FGIDIEGYGEGDVDYEEPINVSIRNNHFVGNVSSSVTNFNGYGILIEGNHSDNTISYG YGTQTVIKGNILRRPEDAAAAPRVGITGLGVSQGKETSDAVIAGNLITGFSTGIDVRG KSVLVTNNKISNFENTGILVYQSSDVKVDGNQIQNGLSETRRSIGLRAVLSDDIAFLN NCLIQVVDGVNVSGGNMIIKDNLLRKFSRGIWIAQGNAVIEGNTLNPDAFEAVPESYS VSVTNNAGAIIKNNTFKEFKNYPIYCSTSAKTSIIGNHLERSPLLVTIYISAGVHEIF DNTISVNRTAGNPIVIYLNGSAGSIISGNTINNLSAGTATAIQTNTSTNSKIIGNRIF KGTINKHSSDTIDGNMIV*" /label="yclG CDS" gene 399560..401314 /gene="yclG" /locus_tag="BSU_03680" /old_locus_tag="BSU03680" /label="yclG gene" promotor_-10 complement(399831..399849) /Source="Nicolas_upshift_promotors" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(399844) /Source="Nicolas_upshifts" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(399865..399870) /Source="Nicolas_upshift_promotors" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 401305 /Source="Nicolas_upshifts" /id="D160" /incds=0 /nref=6 /ntot=21 /MaxReadThrough="0.325519999999999" /MaxDrop="4.9689" /score="4.29139266" /energy="-5.4" /TU="NA" /idTUdmin="U282" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(401330..401551) /gene="yczF" /locus_tag="BSU_03690" /old_locus_tag="BSU03690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388251.1" /db_xref="EnsemblGenomes-Gn:BSU03690" /db_xref="EnsemblGenomes-Tr:CAB12177" /db_xref="GOA:O31479" /db_xref="SubtiList:BG12780" /db_xref="UniProtKB/Swiss-Prot:O31479" /translation="MKILGVTGFILICLLAISVLMDMLQGFSLTKAVYNNMSSFKMTT FAEWVVLLFFVLVLVREMYVIYKSKKKNP*" /label="yczF CDS" gene complement(401330..401551) /gene="yczF" /locus_tag="BSU_03690" /old_locus_tag="BSU03690" /label="yczF gene" promotor_-10 complement(401570..401581) /Source="Nicolas_upshift_promotors" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(401572) /Source="Nicolas_upshifts" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(401596..401602) /Source="Nicolas_upshift_promotors" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 401617..401623 /Source="Nicolas_upshift_promotors" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 401637..401648 /Source="Nicolas_upshift_promotors" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 401650 /Source="Nicolas_upshifts" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="upshifts" CDS 401677..403311 /gene="gerKA" /locus_tag="BSU_03700" /old_locus_tag="BSU03700" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 16707705, 16740944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 16707705, 16740944; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388252.1" /db_xref="EnsemblGenomes-Gn:BSU03700" /db_xref="EnsemblGenomes-Tr:CAB12178" /db_xref="GOA:P49939" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG11392" /db_xref="UniProtKB/Swiss-Prot:P49939" /translation="MPLFSKRKNNTDSKDKQNTDERNQEQQQEKERPVLISPSLAKNI AETKKEVGSSSDVIIREIKIGEQDHVHLAVIYISGLVDNNTIHESLIDPLVQDESIQN THAIQQILEKTLPLGGVKAEKSWDKLFSELMLGNALIFADGHDEALICSTQGGEQRSI QEPSTQVSFRGPRQGFTESLQTNISMIRRYIKNPNLWVEKMKKGSVTNTDIALMYIQG ICDEKVLKEVKQRLEKIDIDSILESGYIEQLIEDETFTTFPTMYHTERPDVVAGNLLE GRFAIIVDGTPFVLIAPALFVQFFQSVEDYYSRFDIATSIRILRVLVFFISLVAPAVY VAATTFHQEMIPTQLLVVIAAQREIVPFPAVVEALTMEVAFEILREAGVRLPRVVGSA VSIVGALVIGQAAVQAGIVSPAMVIIVALTAIASFATPAFAMAISARLIRFIFIIASA VMGFYGLILGIIMMFVHLCSLRSFGVPYMSPLAPFSSQGVKDALFRVPWWADEKRPES VSKEDKVRQGKDQRPEPAASRGMVNKDLEEGDQNGT*" /label="gerKA CDS" gene 401677..403311 /gene="gerKA" /locus_tag="BSU_03700" /old_locus_tag="BSU03700" /label="gerKA gene" CDS 403301..404524 /gene="gerKC" /locus_tag="BSU_03710" /old_locus_tag="BSU03710" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 16707705, 16740944, 19363077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 16707705, 16740944, 19363077; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388253.1" /db_xref="EnsemblGenomes-Gn:BSU03710" /db_xref="EnsemblGenomes-Tr:CAB12179" /db_xref="GOA:P49941" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG11394" /db_xref="UniProtKB/Swiss-Prot:P49941" /translation="MVRKCLLAVLMLLSVIVLPGCWDKRELTDLAIISAIGIDRTNDS NYVLHLQIINPGNVAGGLQGGGAGDRPPVSVYSIEGNNITEALRKASMKVSRRLYFAH TNLVVINEKLAKEEGLDFVLDNLDRDTEFRTTATFVVAHKTKAENIVKILTPIDKIPS NKVNKTLDFTEAQYGRVVKINIQDVLKTLAANTMAPVIPGYMMIGDDKKGVSMENTQA TDPKAILQADGLAVFDKAGYLKYWLEDDESVGAVWLMNKIQHTFINADWGKTKDAVSL QVTHQDTKLVPKMRNGRPYIHVKVSVEGIIDAVKYPFQLSDPKVLAAIEKALNKELEK EISHTVKKIKKNKIDFIGFGDTIYRKYPEQWEKMKDTWDKEYLPELPIDVKAETYIRR TGLRNNPIKHQFKDD*" /label="gerKC CDS" gene 403301..404524 /gene="gerKC" /locus_tag="BSU_03710" /old_locus_tag="BSU03710" /label="gerKC gene" CDS 404549..405670 /gene="gerKB" /locus_tag="BSU_03720" /old_locus_tag="BSU03720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 15849754, 16707705, 16740944, 16850406, 19363077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 15849754, 16707705, 16740944, 16850406, 19363077; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388254.1" /db_xref="EnsemblGenomes-Gn:BSU03720" /db_xref="EnsemblGenomes-Tr:CAB12180" /db_xref="GOA:P49940" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG11393" /db_xref="UniProtKB/Swiss-Prot:P49940" /translation="MEKARISIRQLFVMIIIFELGSSLLITPGSMAGRDAWIAVLLGC AIGLFLFYLYQGIYQCYPNSSPKEYMDDMLGTKLSWLFSFLYILYFAYIAARVLRDFG EMLLTFAYHDTPIIIVNALLMVVSIYAVRKGIEVLARAAELLFGAMYLLGAIGLVLII VSGTIDPHNLKPVLANGISPVLHSVFTQTMYVPFGEVVLFVMIFPNLNDRKDVKKMGM IAMAISGLIVALTVAINISVLDVDLTLRSQFPLLSTIQTIKVEEFLDRLDVFFMLALI IGGFFKVSLYLYATVVGTSTLFKEKNPSQLAYPMGLGILILSITIATNFSEHLNEGLN VVPLYIHLPFQLLFPLFLFIVAVWKKKRREKSKGEEAKK*" /label="gerKB CDS" gene 404549..405670 /gene="gerKB" /locus_tag="BSU_03720" /old_locus_tag="BSU03720" /label="gerKB gene" downshifts 405654 /Source="Nicolas_upshifts" /id="D161" /incds=0 /nref=6 /ntot=58 /MaxReadThrough="2.55658" /MaxDrop="3.73002" /score="3.39927899" /energy="-10.5" /TU="NA" /idTUdmin="U285" /TUdmin=2200 /isTUend="FALSE" /label="downshifts" CDS complement(405775..406455) /gene="yclH" /locus_tag="BSU_03730" /old_locus_tag="BSU03730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATPase component)" /protein_id="NP_388255.1" /db_xref="EnsemblGenomes-Gn:BSU03730" /db_xref="EnsemblGenomes-Tr:CAB12181" /db_xref="GOA:P94411" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12029" /db_xref="UniProtKB/Swiss-Prot:P94411" /translation="MSLLQFQQVGYWYKNKSQPLFQDINISFQKGKFYTIVGTSGTGK TTFLSLAGGLDAPKEGNILYDGKAVSKIGLTNFRNQYVSIVFQAYNLLPYMTALQNVT TAMEITGSKEKNKESYALDMLQKVGINEKQARQKVLTLSGGQQQRVSITRAFCCDTDL IVADEPTGNLDEDTSKEIVRLFQDLAHKEDKCVIMVTHDEQIAKVSDINIRLSRGSFT VKENVAVV*" /label="yclH CDS" gene complement(405775..406455) /gene="yclH" /locus_tag="BSU_03730" /old_locus_tag="BSU03730" /label="yclH gene" CDS complement(406471..407931) /gene="yclI" /locus_tag="BSU_03740" /old_locus_tag="BSU03740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388256.2" /db_xref="EnsemblGenomes-Gn:BSU03740" /db_xref="EnsemblGenomes-Tr:CAB12182" /db_xref="GOA:P94412" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG12030" /db_xref="UniProtKB/Swiss-Prot:P94412" /translation="MNFIKRAFWNMKAKKGKTLLQLFVFTVICVFVLSGLAIQSAAQK SSELARQELGGSVTLQVDRQKQMEKQQDSGEKRSFESTPIKVSDANKLAALDHVKSYN YTTSASANAGNFDAIESSSSSDSSSSSSSSNAKNSQGGGQGGPQMVQADLSIEGVIST ALVDDFSDGDSKITDGRAITKSDVGKKVTVINETLAEENDLSVGDSITIESATDEDTT VKLKIVGIYKTTSSGDDQAQNFSFLNPYNKLYTPYTATAALKGDDYKNTIDSAVYYMD DAKNMDTFVKAAKKTSIDFDTYTLNTNDQLYQQMVGPIENVASFSKNVVYLVSVAGAV ILGLIVMMSIRERKYEMGVLMAIGEKRWKLIGQFLTEILIVAVIAIGLASVTGNLVAN QLGNQLLSQQISSSTDSTQTASGQMPGGGGGMGGKMFGHSSSNVDVIDSLNVAVSMND MLILGGIGILIAIIATLLPSISVLRLHPKTILTKQE*" /label="yclI CDS" gene complement(406471..407931) /gene="yclI" /locus_tag="BSU_03740" /old_locus_tag="BSU03740" /label="yclI gene" misc_feature 408101..408120 /Source="Nicolas_upshift_promotors" /id="U286" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.647352647352647" /psig="0.962037962037962" /xcortree=1584 /SigmaFactorBS="tctagttgatgaaataaaaactaacaattgtgaaacgcaaaa ccttctgtttaaaatGGTGCTATTATATAAAAAAGcatcaaaacaaccggaggatata a" /listShort="yclJ, yclK, S129, rapC, phrC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 408104 /Source="Nicolas_upshifts" /id="U286" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.647352647352647" /psig="0.962037962037962" /xcortree=1584 /SigmaFactorBS="tctagttgatgaaataaaaactaacaattgtgaaacgcaaaa ccttctgtttaaaatGGTGCTATTATATAAAAAAGcatcaaaacaaccggaggatata a" /listShort="yclJ, yclK, S129, rapC, phrC" /GFF_Attribute="listLong" /label="upshifts" CDS 408144..408827 /gene="yclJ" /locus_tag="BSU_03750" /old_locus_tag="BSU03750" /function="16.10: Respire" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15375128, 20512483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15375128, 20512483; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YclK] (possibly involved in arabinogalactan metabolism)" /protein_id="NP_388257.1" /db_xref="EnsemblGenomes-Gn:BSU03750" /db_xref="EnsemblGenomes-Tr:CAB12183" /db_xref="GOA:P94413" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12031" /db_xref="UniProtKB/Swiss-Prot:P94413" /translation="MKILMIEDNVSVCTMTEMFFFKEGFEAEFVHDGLEGYQRFTEEN WDLIILDIMLPSMDGVTICRKIRETSTVPIIMLTAKDTESDQVIGFEMGADDYVTKPF SPLTLVARIKAVIRRYKATGKAVIDEDMIETECFTINKKTREVLLNGEPVENLTPKEF DLLYYLVQNPRQVFSREQLLEQVWGYQFYGDERTVDVHIKRLRKKLASEDKPFLYTVW GVGYKFDED*" /label="yclJ CDS" gene 408144..408827 /gene="yclJ" /locus_tag="BSU_03750" /old_locus_tag="BSU03750" /label="yclJ gene" CDS 408814..410235 /gene="yclK" /locus_tag="BSU_03760" /old_locus_tag="BSU03760" /function="16.3: Control" /function="16.10: Respire" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15375128, 20512483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15375128, 20512483; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YclJ]" /protein_id="NP_388258.1" /db_xref="EnsemblGenomes-Gn:BSU03760" /db_xref="EnsemblGenomes-Tr:CAB12184" /db_xref="GOA:P94414" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12032" /db_xref="UniProtKB/Swiss-Prot:P94414" /translation="MMKIKYLYQLLLSHISILILAFVIIISLFSHFVKEFAYQNKVEE LTSYAVQIANEFQSGQVDMRRLYPYQDILSTRKTQFIIFNEEQQPYFLPEGFHHPPRE QLKKSEWNKLKKGQTVTIRADGRFDDEVSLVAQPIFVQNEFKGAVLLISPISGVEQMV NQVNLYMFYAVISTLVITILVSWLLSKFHVKRIQKLREATDKVASGDYDIHLENSYGD EIGVLASDFNIMAKKLKQSRDEIERLEKRRRQFIADVSHELKTPLTTINGLVEGLNSH TIPEDKKDKCFSLISEETKRMLRLVKENLDYEKIRSQQITLNKLDVPLIEVFEIVKEH LQQQAEEKQNKLMIQVEDHVIVHADYDRFIQILVNITKNSIQFTQNGDIWLRGMEGYK ETIIEIEDTGIGIPKEDIEHIWERFYKADISRTNTAYGEYGLGLSIVRQLVEMHQGTV EIKSEEGKGTKFIIRLPLTAKQQ*" /label="yclK CDS" gene 408814..410235 /gene="yclK" /locus_tag="BSU_03760" /old_locus_tag="BSU03760" /label="yclK gene" downshifts 410211 /Source="Nicolas_upshifts" /id="D162" /incds=0 /nref=20 /ntot=169 /MaxReadThrough="3.43905" /MaxDrop="4.91565" /score="13.4599201" /energy="-15" /TU="U286" /idTUdmin="U286" /TUdmin="-1427" /isTUend="FALSE" /label="downshifts" S_feature 410256..410360 /Source="Nicolas_S_feature" /locus_tag="new_428689_428793" /HighExp="Lbstat, nit, ferm, BI, M0t45, M40t45, M0t90, S0, S2, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S129" misc_feature 410350..410369 /Source="Nicolas_upshift_promotors" /id="U287" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.986013986013986" /xcortree=678 /SigmaFactorBS="tcccgaaaacaaagattgcgtgtttttcgggttgggacggcc tataaaCATGATAAAATATGACATAAacagtttttgatgggagagggtgaaggaatga a" /listShort="rapC, phrC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 410362 /Source="Nicolas_upshifts" /id="U287" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.986013986013986" /xcortree=678 /SigmaFactorBS="tcccgaaaacaaagattgcgtgtttttcgggttgggacggcc tataaaCATGATAAAATATGACATAAacagtttttgatgggagagggtgaaggaatga a" /listShort="rapC, phrC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(410394) /Source="Nicolas_upshifts" /id="D163" /incds=0 /nref=2 /ntot=81 /MaxReadThrough="1.74985" /MaxDrop="4.10695" /score="1.47729412" /energy="-10.3" /TU="NA" /idTUdmin="U290" /TUdmin=1320 /isTUend="FALSE" /label="downshifts" CDS 410398..411546 /gene="rapC" /locus_tag="BSU_03770" /old_locus_tag="BSU03770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10464187, 12456319, 12897006, 12950917, 15968044, 19202088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464187, 12456319, 12897006, 12950917, 15968044, 19202088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388259.1" /db_xref="EnsemblGenomes-Gn:BSU03770" /db_xref="EnsemblGenomes-Tr:CAB12185" /db_xref="GOA:P94415" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11966" /db_xref="UniProtKB/Swiss-Prot:P94415" /translation="MKSGVIPSSAVGQKINEWYRYIRTFSVPDAEVLKAEIQQELKHM QHDSNLLLYYSLMEFRHQLMLDYLEPLEKLNIEDQPSLSELSRNIDSNQADLKGLLDY YVNFFRGMYEFDKREFISAITYYKQAEKKLSFVADHIERAEFYFKIAEAYYYMKQTYF SLINIKNAYEIYVEQETYNVRIIQCHFVFGVNLMDERNFEQAARHFKLALNMAQAEQK AQLVGRAYYNLGLCYYNQDLLDPAIDYFEKAVSTFESSRIVNSLPQAYFLITLIYYKQ GKHDKASEYHKRGYEYAKETDDADYAVKFEFLQSLYLDQPNEEGIERCFQYLKNKNMY ADIEDLALEVAKYYYEQKWFKLSASYFLQVEEARKQIQRSEGLYEIEI*" /label="rapC CDS" gene 410398..411546 /gene="rapC" /locus_tag="BSU_03770" /old_locus_tag="BSU03770" /label="rapC gene" promotor_-35 411246..411251 /Source="Nicolas_upshift_promotors" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 411264 /Source="Nicolas_upshifts" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 411268..411286 /Source="Nicolas_upshift_promotors" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 411408..411416 /Source="Nicolas_upshift_promotors" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 411428..411446 /Source="Nicolas_upshift_promotors" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 411440 /Source="Nicolas_upshifts" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="upshifts" CDS 411530..411652 /gene="phrC" /locus_tag="BSU_03780" /old_locus_tag="BSU03780" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464187, 12456319, 12897006, 12950917, 16816200, 19202088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464187, 12456319, 12897006, 12950917, 16816200, 19202088; Product type r : regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapC and competence and sporulation stimulating factor (CSF)" /protein_id="NP_388260.1" /db_xref="EnsemblGenomes-Gn:BSU03780" /db_xref="EnsemblGenomes-Tr:CAB12186" /db_xref="GOA:P94416" /db_xref="InterPro:IPR020243" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11959" /db_xref="UniProtKB/Swiss-Prot:P94416" /translation="MKLKSKLFVICLAAAAIFTAAGVSANAEALDFHVTERGMT*" /label="phrC CDS" gene 411530..411652 /gene="phrC" /locus_tag="BSU_03780" /old_locus_tag="BSU03780" /label="phrC gene" downshifts 411639 /Source="Nicolas_upshifts" /id="D164" /incds=0 /nref=260 /ntot=275 /MaxReadThrough="3.24518" /MaxDrop="7.70367" /score="26.3182765" /energy="-14" /TU="NA" /idTUdmin="U286" /TUdmin=1 /isTUend="TRUE" /label="downshifts" downshifts complement(411707) /Source="Nicolas_upshifts" /id="D165" /incds=0 /nref=3 /ntot=64 /MaxReadThrough="0.60499" /MaxDrop="7.4475" /score="-1.25354129" /energy="-15.8" /TU="NA" /idTUdmin="U290" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(411752..411841) /gene="yczM" /locus_tag="BSU_03788" /old_locus_tag="BSU03788" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097676.1" /db_xref="EnsemblGenomes-Gn:BSU03788" /db_xref="EnsemblGenomes-Tr:CAX52547" /db_xref="GOA:C0H3V0" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3V0" /translation="MSGYGTSFALIVVLFILLIIVGTAFVGGY*" /label="yczM CDS" gene complement(411752..411841) /gene="yczM" /locus_tag="BSU_03788" /old_locus_tag="BSU03788" /label="yczM gene" downshifts complement(411912) /Source="Nicolas_upshifts" /id="D166" /incds=0 /nref=25 /ntot=113 /MaxReadThrough="7.05273" /MaxDrop="3.3619" /score="32.1465401" /energy="-16.5" /TU="U290" /idTUdmin="U290" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS complement(411923..412036) /gene="yczN" /locus_tag="BSU_03789" /old_locus_tag="BSU03789" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore and germination protein" /protein_id="YP_003097677.1" /db_xref="EnsemblGenomes-Gn:BSU03789" /db_xref="EnsemblGenomes-Tr:CAX52548" /db_xref="GOA:C0H3V1" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3V1" /translation="MSGYSNGGGYGGISSFALIVVLFILLIIVGTAFVGGF*" /label="yczN CDS" gene complement(411923..412036) /gene="yczN" /locus_tag="BSU_03789" /old_locus_tag="BSU03789" /label="yczN gene" promotor_-10 complement(412057..412076) /Source="Nicolas_upshift_promotors" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(412068) /Source="Nicolas_upshifts" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(412089..412098) /Source="Nicolas_upshift_promotors" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(412190..413554) /gene="thrD" /locus_tag="BSU_03790" /old_locus_tag="BSU03790" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2152900, 11471740, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2152900, 11471740, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate kinase III" /protein_id="NP_388261.1" /db_xref="EnsemblGenomes-Gn:BSU03790" /db_xref="EnsemblGenomes-Tr:CAB12187" /db_xref="GOA:P94417" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR035804" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12033" /db_xref="UniProtKB/Swiss-Prot:P94417" /translation="MKVVKFGGSSLASGAQLDKVFHIVTSDPARKAVVVSAPGKHYAE DTKVTDLLIACAEQYLATGSAPELAEAVVERYALIANELQLGQSIIEKIRDDLFTLLE GDKSNPEQYLDAVKASGEDNNAKLIAAYFRYKGVKAEYVNPKDAGLFVTNEPGNAQVL PESYQNLYRLRERDGLIIFPGFFGFSKDGDVITFSRSGSDITGSILANGLQADLYENF TDVDAVYSVNPSFVENPKEISELTYREMRELSYAGFSVFHDEALIPAFRAGIPVQIKN TNNPSAEGTRVVSKRDNTNGPVVGIASDTGFCSIYISKYLMNREIGFGRRALQILEEH GLTYEHVPSGIDDMTIILRQGQMDAATERSVIKRIEEDLHADEVIVEHHLALIMVVGE AMRHNVGTTARAAKALSEAQVNIEMINQGSSEVSMMFGVKEAEERKAVQALYQEFFAG VLIS*" /label="thrD CDS" gene complement(412190..413554) /gene="thrD" /locus_tag="BSU_03790" /old_locus_tag="BSU03790" /label="thrD gene" downshifts complement(412198) /Source="Nicolas_upshifts" /id="D167" /incds=0 /nref=23 /ntot=129 /MaxReadThrough="2.21842" /MaxDrop="4.81019" /score="44.9085917" /energy="-15" /TU="NA" /idTUdmin="U291" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(412242) /Source="Nicolas_upshifts" /id="D168" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="5.53807" /MaxDrop="2.54279" /score="44.9085917" /energy="-15" /TU="U291" /idTUdmin="U291" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(413590..413609) /Source="Nicolas_upshift_promotors" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(413606) /Source="Nicolas_upshifts" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(413624..413631) /Source="Nicolas_upshift_promotors" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 413745..413749 /Source="Nicolas_upshift_promotors" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 413765..413784 /Source="Nicolas_upshift_promotors" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 413777 /Source="Nicolas_upshifts" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 413808..413815 /Source="Nicolas_upshift_promotors" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 413829..413848 /Source="Nicolas_upshift_promotors" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 413838..413938 /Source="Nicolas_S_feature" /locus_tag="new_432271_432371" /HighExp="LBGexp, Lbexp, G150, dia0, G135, H2O2, Paraq, dia15, G180, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S130" upshifts 413838 /Source="Nicolas_upshifts" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="upshifts" CDS 413939..414889 /gene="pbtN" /locus_tag="BSU_03800" /old_locus_tag="BSU03800" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (permease)" /protein_id="NP_388262.1" /db_xref="EnsemblGenomes-Gn:BSU03800" /db_xref="EnsemblGenomes-Tr:CAB12188" /db_xref="GOA:P94418" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12034" /db_xref="UniProtKB/Swiss-Prot:P94418" /translation="MKLRYLFILLIILAVTSVFIGVEDLSPLDLFDLSKQEASTLFAS RLPRLISIVIAGLSMSICGLIMQQISRNKFVSPTTAGTMDWARLGILISLLLFTSASP LIKMLVAFVFALAGNFLFMKILERIKFNDTIFIPLVGLMLGNIVSSIATFIAYKYDLI QNVSSWLQGDFSLVVKGRYELLYLSIPLVIIAYVYADKFTLAGMGESFSVNLGLKYKR VVNIGLIIVSLITSLVILTVGMLPFLGLIIPNIVSIYRGDNLKSSLPHTVLLGAVFVL FCDILGRIIIFPYEISIGLMVGIIGSGIFLFMLLRRKAYA*" /label="pbtN CDS" gene 413939..414889 /gene="pbtN" /locus_tag="BSU_03800" /old_locus_tag="BSU03800" /label="pbtN gene" CDS 414882..415829 /gene="pbtO" /locus_tag="BSU_03810" /old_locus_tag="BSU03810" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (permease)" /protein_id="NP_388263.1" /db_xref="EnsemblGenomes-Gn:BSU03810" /db_xref="EnsemblGenomes-Tr:CAB12189" /db_xref="GOA:P94419" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12035" /db_xref="UniProtKB/Swiss-Prot:P94419" /translation="MRNQMKIALLVGLAIVCIGLFLFYDLGNWDYTLPRRIKKVAAIV LTGGAIAFSTMIFQTITNNRILTPSILGLDSLYMLIQTGIIFLFGSANMVIMNKNINF IISVLLMILFSLVLYQIMFKGEGRNIFFLLLIGIVFGTLFSSLSSFMQMLIDPNEFQV VQDKMFASFNNINTDLLWLAFIIFLLTGVYVWRFTKFFDVLSLGREHAVNLGIDYDKV VKQMLIVVAILVSVSTALVGPIMFLGLLVVNLAREFLKTYKHSYLIAGSVFISIIALV GGQFVVEKVFTFSTTLSVIINFAGGIYFIYLLLKENKSW*" /label="pbtO CDS" gene 414882..415829 /gene="pbtO" /locus_tag="BSU_03810" /old_locus_tag="BSU03810" /label="pbtO gene" CDS 415823..416581 /gene="pbtP" /locus_tag="BSU_03820" /old_locus_tag="BSU03820" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (ATP-binding protein)" /protein_id="NP_388264.1" /db_xref="EnsemblGenomes-Gn:BSU03820" /db_xref="EnsemblGenomes-Tr:CAB12190" /db_xref="GOA:P94420" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12036" /db_xref="UniProtKB/Swiss-Prot:P94420" /translation="MVEVRNVSKQYGGKVVLEETSVTIQKGKITSFIGPNGAGKSTLL SIMSRLIKKDSGEIYIDGQEIGACDSKELAKKMSILKQANQINIRLTIKDLVSFGRFP YSQGRLTEEDWVHINQALSYMKLEDIQDKYLDQLSGGQCQRAFIAMVIAQDTDYIFLD EPLNNLDMKHSVEIMKLLKRLVEELGKTIVIVIHDINFASVYSDYIVALKNGRIVKEG PPEEMIETSVLEEIYDMTIPIQTIDNQRIGVYFS*" /label="pbtP CDS" gene 415823..416581 /gene="pbtP" /locus_tag="BSU_03820" /old_locus_tag="BSU03820" /label="pbtP gene" CDS 416603..417556 /gene="pbtQ" /locus_tag="BSU_03830" /old_locus_tag="BSU03830" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 19955416, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 19955416, 25355936; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (binding lipoprotein)" /protein_id="NP_388265.1" /db_xref="EnsemblGenomes-Gn:BSU03830" /db_xref="EnsemblGenomes-Tr:CAB12191" /db_xref="GOA:P94421" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR033870" /db_xref="PDB:3GFV" /db_xref="SubtiList:BG12037" /db_xref="UniProtKB/Swiss-Prot:P94421" /translation="MKKFALLFIALVTAVVISACGNQSTSSKGSDTKKEQITVKHQLD KNGTKVPKNPKKVVVFDFGSLDTLDKLGLDDIVAGLPKQVLPKYLSKFKDDKYADVGS LKEPDFDKVAELDPDLIIISARQSESYKEFSKIAPTIYLGVDTAKYMESFKSDAETIG KIFDKEDKVKDELANIDHSIADVKKTAEKLNKNGLVIMANDGKISAFGPKSRYGLIHD VFGVAPADQNIKASTHGQSVSYEYISKTNPDYLFVIDRGTAIGETSSTKQVVENDYVK NVNAVKNGHVIYLDSATWYLSGGGLESMTQMIKEVKDGLEK*" /label="pbtQ CDS" gene 416603..417556 /gene="pbtQ" /locus_tag="BSU_03830" /old_locus_tag="BSU03830" /label="pbtQ gene" downshifts 417539 /Source="Nicolas_upshifts" /id="D169" /incds=0 /nref=161 /ntot=280 /MaxReadThrough="3.87669" /MaxDrop="7.4722" /score="31.9942335" /energy="-13.8" /TU="U293" /idTUdmin="U292" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(417603..419021) /gene="ycnB" /locus_tag="BSU_03840" /old_locus_tag="BSU03840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15855514, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388266.1" /db_xref="EnsemblGenomes-Gn:BSU03840" /db_xref="EnsemblGenomes-Tr:CAB12192" /db_xref="GOA:P94422" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12038" /db_xref="UniProtKB/Swiss-Prot:P94422" /translation="MNTSIEQKPFNRSVIVGILLAGAFVAILNQTLLITALPHIMRDF NVDANQAQWLTTSFMLTNGILIPITAFLIEKFTSRALLITAMSIFTAGTVVGAFAPNF PVLLTARIIQAAGAGIMMPLMQTVFLTIFPIEKRGQAMGMVGLVISFAPAIGPTLSGW AVEAFSWRSLFYIILPFAVIDLILASILMKNVTTLRKTQIDILSVILSTFGFGGLLYG FSSVGSYGWSSSTVLISLLVGVIALLLFITRQMKLKKPMLEFRVFTFGVFSLTTLLGT LVFALLIGTETILPLYTQNVRDVTAFDTGLMLLPGAVVMGFMSPIIGRIFDRVGGRGL AIAGFCIIFLTSLPFMQLTDHTSLAWIVVLYTVRLLGTAMIMMPVTTAGINALPRHLI PHGTAMNNTIRQVGGSIGTALLVSVMSNQAAHAGTTNVKHAALHGMNAAFIVAAVIAL VGFLLSFTLKKPQRPAEQQPAR*" /label="ycnB CDS" gene complement(417603..419021) /gene="ycnB" /locus_tag="BSU_03840" /old_locus_tag="BSU03840" /label="ycnB gene" downshifts complement(417624) /Source="Nicolas_upshifts" /id="D170" /incds=0 /nref=8 /ntot=150 /MaxReadThrough="2.00954" /MaxDrop="5.13029" /score="17.5501827" /energy="-13.8" /TU="NA" /idTUdmin="U294" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(419041..419919) /gene="ycnC" /locus_tag="BSU_03850" /old_locus_tag="BSU03850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388267.2" /db_xref="EnsemblGenomes-Gn:BSU03850" /db_xref="EnsemblGenomes-Tr:CAB12193" /db_xref="GOA:P94423" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12039" /db_xref="UniProtKB/Swiss-Prot:P94423" /translation="MLDKKTDILLAARKLFSEKDFTSVSMQAIAEECKMSKASIYKLF QSKEDLLLELLSFNQKQMVAAASRLQENTALTPEERLTQKVKMELEGFRRNQQFFNML TYGNPKLHNDRVKQHIHQTRSTIICWHRDSLIQAYGETILPFVWDLVIILHGMMREFL MLIKIEEKPLELDPIAEFIISTLNQIIKNRETRQSLLPPEAIELYIHSASSYKPKDKS VLLSESLKELHKGISSLSAADYDVDELTSAAAMLEEEAKKEEPRAFLLKSLIGYLEQT GVLTQPVSMLKTLLIT*" /label="ycnC CDS" gene complement(419041..419919) /gene="ycnC" /locus_tag="BSU_03850" /old_locus_tag="BSU03850" /label="ycnC gene" S_feature complement(419920..419986) /Source="Nicolas_S_feature" /locus_tag="new_438353_438419_c" /HighExp="dia15, H2O2, Diami, Paraq, Oxctl, Cold, G180, Salt, BMM, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S131" promotor_-10 complement(419985..420004) /Source="Nicolas_upshift_promotors" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(419994) /Source="Nicolas_upshifts" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(420019..420025) /Source="Nicolas_upshift_promotors" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(420083..420832) /gene="nfrAB" /locus_tag="BSU_03860" /old_locus_tag="BSU03860" /EC_number="1.5.1.39" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16229462, 9836433, 20862523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16229462, 9836433, 20862523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-FMN oxidoreductase (nitroreductase)" /protein_id="NP_388268.1" /db_xref="EnsemblGenomes-Gn:BSU03860" /db_xref="EnsemblGenomes-Tr:CAB12194" /db_xref="GOA:P94424" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:1ZCH" /db_xref="SubtiList:BG12040" /db_xref="UniProtKB/Swiss-Prot:P94424" /translation="MNEVIKSLTDHRSIRSYTDEPVAQEQLDQIIEAVQSAPSSINGQ QVTVITVQDKERKKKISELAGGQPWIDQAPVFLLFCADFNRAKIALEDLHDFKMEITN GLESVLVGAVDAGIALGTATAAAESLGLGTVPIGAVRGNPQELIELLELPKYVFPLSG LVIGHPADRSAKKPRLPQEAVNHQETYLNQDELTSHIQAYDEQMSEYMNKRTNGKETR NWSQSIASYYERLYYPHIREMLEKQGFKVEK*" /label="nfrAB CDS" gene complement(420083..420832) /gene="nfrAB" /locus_tag="BSU_03860" /old_locus_tag="BSU03860" /label="nfrAB gene" downshifts complement(420096) /Source="Nicolas_upshifts" /id="D171" /incds=0 /nref=136 /ntot=243 /MaxReadThrough="2.08639" /MaxDrop="5.10745" /score="11.1864402" /energy="-18.6" /TU="NA" /idTUdmin="U296" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(420849..421136) /gene="ycnE" /locus_tag="BSU_03870" /old_locus_tag="BSU03870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17274596, 21454635; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AI-2 degrading enzyme" /protein_id="NP_388269.1" /db_xref="EnsemblGenomes-Gn:BSU03870" /db_xref="EnsemblGenomes-Tr:CAB12195" /db_xref="GOA:P94425" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12041" /db_xref="UniProtKB/Swiss-Prot:P94425" /translation="MIVLQAYIKVKPEKREEFLSEAQSLVQHSRAEEGNAQYDLFEKV GEENTFVMLEKWKDEAAMKFHNETAHFQGFVAKGKELLSAPLDVVRTELSE*" /label="ycnE CDS" gene complement(420849..421136) /gene="ycnE" /locus_tag="BSU_03870" /old_locus_tag="BSU03870" /label="ycnE gene" promotor_-35 421102..421109 /Source="Nicolas_upshift_promotors" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 421123..421142 /Source="Nicolas_upshift_promotors" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 421142 /Source="Nicolas_upshifts" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(421180..421199) /Source="Nicolas_upshift_promotors" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(421196) /Source="Nicolas_upshifts" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(421213..421220) /Source="Nicolas_upshift_promotors" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 421241..421248 /Source="Nicolas_upshift_promotors" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 421253 /Source="Nicolas_upshifts" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 421259..421278 /Source="Nicolas_upshift_promotors" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 421276..421590 /gene="yczG" /locus_tag="BSU_03880" /old_locus_tag="BSU03880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388270.1" /db_xref="EnsemblGenomes-Gn:BSU03880" /db_xref="EnsemblGenomes-Tr:CAB12196" /db_xref="GOA:O31480" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12781" /db_xref="UniProtKB/Swiss-Prot:O31480" /translation="MNIPNHPETETLQLTKVLHALSDPLRLELVKQLAEAKEKTCSTC ADVQVAKSTLSHHFKVLRESGIAQVRIEGKRRYYSLRAEDLEKAFPGLLEAVLNVDQD RW*" /label="yczG CDS" gene 421276..421590 /gene="yczG" /locus_tag="BSU_03880" /old_locus_tag="BSU03880" /label="yczG gene" downshifts 421582 /Source="Nicolas_upshifts" /id="D172" /incds=0 /nref=173 /ntot=262 /MaxReadThrough="0.52252" /MaxDrop="5.32898" /score="20.7855667" /energy="-7.4" /TU="NA" /idTUdmin="U297" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(421592..423031) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /experiment="publication(s) with functional evidences, PMID:15223311, 24127574, 25388514, 27640111, 28348215, 28412355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223311, 24127574, 25388514, 27640111, 28348215, 28412355; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR/MocR family) with PLP binding site (GabR-GABA-PLP aldimine)" /protein_id="NP_388271.1" /db_xref="EnsemblGenomes-Gn:BSU03890" /db_xref="EnsemblGenomes-Tr:CAB12197" /db_xref="GOA:P94426" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4MGR" /db_xref="PDB:4N0B" /db_xref="PDB:4TV7" /db_xref="PDB:5T4J" /db_xref="PDB:5T4K" /db_xref="PDB:5X03" /db_xref="SubtiList:BG12042" /db_xref="UniProtKB/Swiss-Prot:P94426" /translation="MDITITLDRSEQADYIYQQIYQKLKKEILSRNLLPHSKVPSKRE LAENLKVSVNSVNSAYQQLLAEGYLYAIERKGFFVEELDMFSAEEHPPFALPDDLKEI HIDQSDWISFSHMSSDTDHFPIKSWFRCEQKAASRSYRTLGDMSHPQGIYEVRAAITR LISLTRGVKCRPEQMIIGAGTQVLMQLLTELLPKEAVYAMEEPGYRRMYQLLKNAGKQ VKTIMLDEKGMSIAEITRQQPDVLVTTPSHQFPSGTIMPVSRRIQLLNWAAEEPRRYI IEDDYDSEFTYDVDSIPALQSLDRFQNVIYMGTFSKSLLPGLRISYMVLPPELLRAYK QRGYDLQTCSSLTQLTLQEFIESGEYQKHIKKMKQHYKEKRERLITALEAEFSGEVTV KGANAGLHFVTEFDTRRTEQDILSHAAGLQLEIFGMSRFNLKENKRQTGRPALIIGFA RLKEEDIQEGVQRLFKAVYGHKKIPVTGD*" /label="gabR CDS" gene complement(421592..423031) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /label="gabR gene" promotor_-10 complement(421916..421927) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(421922) /Source="Nicolas_upshifts" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(421941..421947) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(423074..423093) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 423075..423082 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(423081) /Source="Nicolas_upshifts" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 423096..423115 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 423100 /Source="Nicolas_upshifts" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(423104..423111) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 423138..424448 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /EC_number="2.6.1.19" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-aminobutyrate aminotransferase" /protein_id="NP_388272.1" /db_xref="EnsemblGenomes-Gn:BSU03900" /db_xref="EnsemblGenomes-Tr:CAB12198" /db_xref="GOA:P94427" /db_xref="InterPro:IPR004632" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12043" /db_xref="UniProtKB/Swiss-Prot:P94427" /translation="MSQTTASITTAQWQQKRDQFVSKGVSNGNRSLAVKGEGAELYDL DGRRFIDFAGAIGTLNVGHSHPKVVEAVKRQAEELIHPGFNVMMYPTYIELAEKLCGI APGSHEKKAIFLNSGAEAVENAVKIARKYTKRQGVVSFTRGFHGRTNMTMSMTSKVKP YKFGFGPFAPEVYQAPFPYYYQKPAGMSDESYDDMVIQAFNDFFIASVAPETVACVVM EPVQGEGGFIIPSKRFVQHVASFCKEHGIVFVADEIQTGFARTGTYFAIEHFDVVPDL ITVSKSLAAGLPLSGVIGRAEMLDAAAPGELGGTYAGSPLGCAAALAVLDIIEEEGLN ERSEEIGKIIEDKAYEWKQEFPFIGDIRRLGAMAAIEIVKDPDTREPDKTKAAAIAAY ANQNGLLLLTAGINGNIIRFLTPLVISDSLLNEGLSILEAGLRA*" /label="gabT CDS" gene 423138..424448 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /label="gabT gene" promotor_-35 424326..424332 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 424346..424364 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 424354 /Source="Nicolas_upshifts" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 424450..424457 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 424472..424491 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 424481 /Source="Nicolas_upshifts" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="upshifts" CDS 424517..425905 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /EC_number="1.2.1.24" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate-semialdehyde dehydrogenase" /protein_id="NP_388273.1" /db_xref="EnsemblGenomes-Gn:BSU03910" /db_xref="EnsemblGenomes-Tr:CAB12199" /db_xref="GOA:P94428" /db_xref="InterPro:IPR010102" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="SubtiList:BG12044" /db_xref="UniProtKB/Swiss-Prot:P94428" /translation="MPDQLTVYNPATGEEIKTIPQQSATEVEEAIERSHQAFKTWSKT SANERTSLLKKWYELIVEHKEELADLITKENGKPYQEAVGEVLYGAGYIEWFAEEAKR VYGRTVPAPTTGKRIVVTRQPVGPVAAITPWNFPNAMITRKAAPALAAGCTFIIKPAP DTPLSAYELARLAYEAGIPKDVLQVVIGDGEEIGNVFTSSPKIRKITFTGSTPVGKIL MKNSADTVKHVSMELGGHAPLIVDEDADIDLAVEQAMASKYRNAGQTCVCANRLIVHE SIKDEFAAKLSEQVSKLKVGNGLEEGVNVGPIINKRGFEKIVSQIDDAVEKGAKVIAG GTYDRNDDKGCYFVNPTVLTDVDTSMNIMHEETFGPVAPIVTFSDIDEAIQLANDTPY GLAAYFFTENYRRGIYISENLEYGIIGWNDGGPSAVQAPFGGMKESGIGREGGSEGIE PYLETKYLSIGL*" /label="gabD CDS" gene 424517..425905 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /label="gabD gene" downshifts 425913 /Source="Nicolas_upshifts" /id="D173" /incds=0 /nref=107 /ntot=240 /MaxReadThrough="0.105510000000001" /MaxDrop="6.52053" /score="38.677658" /energy="-19.9" /TU="NA" /idTUdmin="U301" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 425963..425969 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 425983..425994 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 425984 /Source="Nicolas_upshifts" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="upshifts" CDS 426028..426891 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438764, 15849754, 16850406, 19054326, 21564334, 27329749; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glucose uptake protein" /protein_id="NP_388274.1" /db_xref="EnsemblGenomes-Gn:BSU03920" /db_xref="EnsemblGenomes-Tr:CAB12200" /db_xref="GOA:P40420" /db_xref="InterPro:IPR010651" /db_xref="SubtiList:BG11066" /db_xref="UniProtKB/Swiss-Prot:P40420" /translation="MDLLLALLPALFWGSIVLFNVKLGGGPYSQTLGTTIGALIVSIV IYFFVQPVLSLRIFIVGIVSGLFWSLGQANQLKSIQLMGVSKTMPISTGMQLVSTSLF GVIVFREWSTPIAITLGVLALIFIIVGIILTSLEDKNDKKEGEPSNLKKGILILLVST LGYLVYVVVARLFNVSGWSALLPQAIGMVVGGLVLTYRHKPFNKYAIRNILPGLIWAG GNMFLFISQPRVGVATSFSLSQMGIVISTLGGIFILREKKTKRQLIAIAIGIILIIAA AVFLGIAKTNS*" /label="glcU CDS" gene 426028..426891 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /label="glcU gene" CDS 426911..427696 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /EC_number="1.1.1.47" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2493633, 3141376, 6438057, 16912926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2493633, 3141376, 6438057, 16912926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="forespore glucose 1-dehydrogenase" /protein_id="NP_388275.1" /db_xref="EnsemblGenomes-Gn:BSU03930" /db_xref="EnsemblGenomes-Tr:CAB12201" /db_xref="GOA:P12310" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10545" /db_xref="UniProtKB/Swiss-Prot:P12310" /translation="MYPDLKGKVVAITGAASGLGKAMAIRFGKEQAKVVINYYSNKQD PNEVKEEVIKAGGEAVVVQGDVTKEEDVKNIVQTAIKEFGTLDIMINNAGLENPVPSH EMPLKDWDKVIGTNLTGAFLGSREAIKYFVENDIKGNVINMSSVHEVIPWPLFVHYAA SKGGIKLMTETLALEYAPKGIRVNNIGPGAINTPINAEKFADPKQKADVESMIPMGYI GEPEEIAAVAAWLASKEASYVTGITLFADGGMTQYPSFQAGRG*" /label="gdh CDS" gene 426911..427696 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /label="gdh gene" misc_feature 427016..427035 /Source="Nicolas_upshift_promotors" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 427016 /Source="Nicolas_upshifts" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 427104 /Source="Nicolas_upshifts" /id="D174" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.44884" /MaxDrop="2.47712" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U301" /TUdmin=1188 /isTUend="FALSE" /label="downshifts" downshifts 427698 /Source="Nicolas_upshifts" /id="D175" /incds=0 /nref=4 /ntot=40 /MaxReadThrough="2.7861" /MaxDrop="4.2307" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U303" /TUdmin="-836" /isTUend="FALSE" /label="downshifts" CDS complement(427741..428355) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19168619, 22904286, 27010565, 26822828; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative membrane protein involved in copper intake" /protein_id="NP_388276.1" /db_xref="EnsemblGenomes-Gn:BSU03940" /db_xref="EnsemblGenomes-Tr:CAB12202" /db_xref="GOA:P94431" /db_xref="InterPro:IPR012533" /db_xref="SubtiList:BG12045" /db_xref="UniProtKB/Swiss-Prot:P94431" /translation="MLKKIALTLCPAIVGSLLFFTAPASAHVSVKPAESAAGSWETYT MKVPSEKNLPTTKVVLKMPKDVEFQQYEPIPGWKVSTQKHDDKSVSVTWEATDGGIQE GQFQQFTFVAKNPDKAEEAAWDAYQYYKDGSIVEWTGDEDADTPHSITNITSAKQVTD EHGATKTEDDSENSGSSALDITAMVLSAAAIILSVAALVKKKRA*" /label="cutI CDS" gene complement(427741..428355) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /label="cutI gene" downshifts complement(427752) /Source="Nicolas_upshifts" /id="D176" /incds=0 /nref=95 /ntot=219 /MaxReadThrough="0.879290000000001" /MaxDrop="6.67627" /score="21.5633403" /energy="-16" /TU="NA" /idTUdmin="U305" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(428368..429993) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15101989, 15849754, 16850406, 19168619, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 15849754, 16850406, 19168619, 22904286, 23012364; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper import permease subunit" /protein_id="NP_388277.2" /db_xref="EnsemblGenomes-Gn:BSU03950" /db_xref="EnsemblGenomes-Tr:CAB12203" /db_xref="GOA:C0SP95" /db_xref="InterPro:IPR007348" /db_xref="InterPro:IPR008457" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR032693" /db_xref="InterPro:IPR032694" /db_xref="SubtiList:BG12046" /db_xref="UniProtKB/Swiss-Prot:C0SP95" /translation="MKRNRWWIILLLFLVFLPKTSFAHAYIVKSSPGENSELKSAPAQ VEIEFNEPVEEGFHYIKVYNSNGDRVDTDKTEIKKDNHHIMTVKLKKNLPKDVYRAEW NAVSADGHPVSGVIPFSIGKADGGFSSQKAADSALNPGTAADRAILYTALSLFIGTVF FHLFWYKGKSEQLVKRTRRILTGSIAALGLALLLQLPIQTKANAGGGWGSAFQPGYIR ETLFETAGGSIWIIQAALFVLLALSVIPAIRKNRFSSFGYWTAPLIFFFGLLLAKAFT GHAAVVEEKTVGILMDFLHLTSASIWVGGIAALVLLLSKEWRQPDKTLAWETVRRFSP WALTAVGVILFSGLLNGFFIIRSMDSLFHTAYGQALLVKSGLFVFMLVLGAIHFLLTR KQRRTGISRTLKAEWAIGIAVLITAAVFTSLPSPPEPAPEPFYQTKAIENGQSVSLSI SPNQPGKNVFELRVTDHNGDPVKNIQQITLTVYKTGLSGSENKSTFTLKEKTKGVFQD QNLSINEKGNWKIKVHGLTGDFNEINIMFTKTN*" /label="cutJ CDS" gene complement(428368..429993) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /label="cutJ gene" CDS complement(430028..430600) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 22904286, 23012364; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of copper intake (CutR-Cu(+))" /protein_id="NP_388278.1" /db_xref="EnsemblGenomes-Gn:BSU03960" /db_xref="EnsemblGenomes-Tr:CAB12204" /db_xref="GOA:P94433" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR008719" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12047" /db_xref="UniProtKB/Swiss-Prot:P94433" /translation="MLPINRQQHILKWLKEEGSLRISDISARFGVSEMTVYRDVNQLV QSNQVIKTAGGITLPVRTPQTDHMCSYCLKPVNQAHSVQLITVNQDIEQLCCAHCAFL RYADKTEEVSHLICRDFLLQTTVSAGSAYFVVNAELNLHCCQPQAIPFATLDHAERFQ KGFGGAVCTFDQALEDMLQDRKKRCTCTKK*" /label="cutR CDS" gene complement(430028..430600) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /label="cutR gene" promotor_-10 complement(430622..430641) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(430637) /Source="Nicolas_upshifts" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(430655..430662) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 430722..430741 /Source="Nicolas_upshift_promotors" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 430734 /Source="Nicolas_upshifts" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="upshifts" CDS 430765..431118 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18307109, 27010565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative reductase or disulfide isomerase" /protein_id="NP_388279.1" /db_xref="EnsemblGenomes-Gn:BSU03970" /db_xref="EnsemblGenomes-Tr:CAB12205" /db_xref="GOA:P94434" /db_xref="SubtiList:BG12048" /db_xref="UniProtKB/Swiss-Prot:P94434" /translation="MKETPCPNCGKPLTGDMVRSSNVPCQFRCGHCRERLYEYKVSAP IMLVSLAAIVLLIYLLMLLRNAAGSVLPAVQHVPMAVFALVCAYPVFIVSERMIAKYV IQNGNIIYRGKRKGS*" /label="ycnL CDS" gene 430765..431118 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /label="ycnL gene" downshifts 431089 /Source="Nicolas_upshifts" /id="D177" /incds=0 /nref=136 /ntot=248 /MaxReadThrough="0.860829999999999" /MaxDrop="6.25982" /score="38.4886131" /energy="-13.4" /TU="NA" /idTUdmin="U306" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 431182..431189 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 431203..431222 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 431208 /Source="Nicolas_upshifts" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="upshifts" S_feature 431218..431290 /Source="Nicolas_S_feature" /locus_tag="new_449651_449723" /HighExp="S0, dia5, Gly, G135, B60, T0.30H, BT, G180, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S132" CDS 431291..432727 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IICB component" /protein_id="NP_388280.2" /db_xref="EnsemblGenomes-Gn:BSU03981" /db_xref="EnsemblGenomes-Tr:CAB12206" /db_xref="GOA:P42956" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004718" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR029503" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11215" /db_xref="UniProtKB/Swiss-Prot:P42956" /translation="MQQQEQQQGGMKVKVQRFGSYLSGMIMPNIGAFIAWGIITALFI PAGWFPNEQLNTLVSPMITYLLPLLIAYTGGKMIYDHRGGVVGATAAIGVIVGSDIPM FLGAMIMGPLGGYLIKQTDKLFKDKVKQGFEMLINNFTAGIVGAALTILAFYAIGPVV LTLNKLLAAGVEVIVHANLLPVASVFVEPAKVLFLNNAINHGILSPIGIEQASQTGKS ILFLVEANPGPGLGILLAYMFFGKGSSKSTAPGAAIIHFFGGIHEIYFPYILMKPALI LAAIAGGASGLLTFTIFNAGLVAAASPGSIIALMAMTPRGGYFGVLAGVLVAAAVSFI VSAVILKSSKASEEDLAAATEKMQSMKGKKSQAAAALEAEQAKAEEASELSPESVNKI IFACDAGMGSSAMGASILRNKVKKAELDISVTNTAINNLPSDADIVITHKDLTDRAKA KLPNATHISVDNFLNSPKYDELIEKLKK*" /label="mtlA CDS" gene 431291..432727 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /label="mtlA gene" CDS 432752..433183 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IIA component" /protein_id="YP_003097678.1" /db_xref="EnsemblGenomes-Gn:BSU03982" /db_xref="EnsemblGenomes-Tr:CAX52549" /db_xref="GOA:C0H3V2" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR016152" /db_xref="UniProtKB/Swiss-Prot:C0H3V2" /translation="MQVLAKENIKLNQTVSSKEEAIKLAGQTLIDNGYVTEDYISKMF EREETSSTFMGNFIAIPHGTEEAKSEVLHSGISIIQIPEGVEYGEGNTAKVVFGIAGK NNEHLDILSNIAIICSEEENIERLISAKSEEDLIAIFNEVN*" /label="mtlF CDS" gene 432752..433183 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /label="mtlF gene" CDS 433185..434306 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /EC_number="1.1.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 22014119, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 22014119, 23279188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannitol-1-phosphate 5-dehydrogenase" /protein_id="NP_388281.2" /db_xref="EnsemblGenomes-Gn:BSU03990" /db_xref="EnsemblGenomes-Tr:CAB12207" /db_xref="GOA:P42957" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023027" /db_xref="InterPro:IPR023028" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11216" /db_xref="UniProtKB/Swiss-Prot:P42957" /translation="MIALHFGAGNIGRGFIGALLHHSGYDVVFADVNETMVSLLNEKK EYTVELAEEGRSSEIIGPVSAINSGSQTEELYRLMNEAALITTAVGPNVLKLIAPSIA EGLRRRNTANTLNIIACENMIGGSSFLKKEIYSHLTEAEQKSVSETVGFPNSAVDRIV PIQHHEDPLKVSVEPFFEWVIDESGFKGKTPVINGALFVDDLTPYIERKLFTVNTGHA VTAYVGYQRGLKTVKEAIDHPEIRRVVHSALLETGDYLVKSYGFKQTEHEQYIKKIIG RFENPFISDDVTRVARSPLRKLGENDRLVGPAKKIKEPNALAEGIAAALRFDFTGDPE AVELQALIEEKGYSGVLQEVCGIQSHEPLHAIILKKLNQ*" /label="mtlD CDS" gene 433185..434306 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /label="mtlD gene" downshifts 434289 /Source="Nicolas_upshifts" /id="D178" /incds=0 /nref=46 /ntot=156 /MaxReadThrough="5.56503" /MaxDrop="4.72154" /score="32.3837677" /energy="-13.4" /TU="U307" /idTUdmin="U308" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-35 434335..434338 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-35" promotor_-10 434354..434373 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-10" upshifts 434356 /Source="Nicolas_upshifts" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="upshifts" CDS 434397..435461 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /EC_number="1.1.1.93" /EC_number="1.1.1.83" /EC_number="4.1.1.73" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10568751, 12356321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tartrate dehydrogenase" /protein_id="NP_388282.3" /db_xref="EnsemblGenomes-Gn:BSU04000" /db_xref="EnsemblGenomes-Tr:CAB12208" /db_xref="GOA:P42958" /db_xref="InterPro:IPR011829" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG11222" /db_xref="UniProtKB/Swiss-Prot:P42958" /translation="MTMKQFEIAAIPGDGVGKEVVAAAEKVLHTAAEVHGGLSFSFTA FPWSCDYYLEHGKMMPEDGIHTLTQFEAVFLGAVGNPKLVPDHISLWGLLLKIRRELE LSINMRPAKQMAGITSPLLHPNDFDFVVIRENSEGEYSEVGGRIHRGDDEIAIQNAVF TRKATERVMRFAFELAKKRRSHVTSATKSNGIYHAMPFWDEVFQQTAADYSGIETSSQ HIDALAAFFVTRPETFDVIVASNLFGDILTDISSSLMGSIGIAPSANINPSGKYPSMF EPVHGSAPDIAGQGLANPIGQIWTAKLMLDHFGEEELGAKILDVMEQVTADGIKTRDI GGQSTTAEVTDEICSRLRKL*" /label="ycsA CDS" gene 434397..435461 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /label="ycsA gene" promotor_-35 434631..434639 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 434653..434672 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 434663 /Source="Nicolas_upshifts" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 435455 /Source="Nicolas_upshifts" /id="D179" /incds=0 /nref=7 /ntot=41 /MaxReadThrough="4.24123" /MaxDrop="4.42639" /score="9.70532694" /energy="-11.6" /TU="U307,U308" /idTUdmin="U308" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 435528..435535 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 435548..435567 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 435561 /Source="Nicolas_upshifts" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="upshifts" CDS 435596..436159 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11856304, 14568161" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11856304, 14568161; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388283.1" /db_xref="EnsemblGenomes-Gn:BSU04010" /db_xref="EnsemblGenomes-Tr:CAB12209" /db_xref="GOA:P42959" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11223" /db_xref="UniProtKB/Swiss-Prot:P42959" /translation="MNAKTITLKKKRKIKTIVVLSIIMIAALIFTIRLVFYKPFLIEG SSMAPTLKDSERILVDKAVKWTGGFHRGDIIVIHDKKSGRSFVKRLIGLPGDSIKMKN DQLYINDKKVEEPYLKEYKQEVKESGVTLTGDFEVEVPSGKYFVMGDNRLNSLDSRNG MGMPSEDDIIGTESLVFYPFGEMRQAK*" /label="sipU CDS" gene 435596..436159 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /label="sipU gene" S_feature 436160..436884 /Source="Nicolas_S_feature" /locus_tag="new_454593_455317" /HighExp="G150, Oxctl, Lbexp, G135, Paraq, dia0, LBGexp, Mt0, G180, dia15" /AntisenseName="yczH" /AntisenseCor="0.134432865921808" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S133" CDS complement(436219..436827) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388284.2" /db_xref="EnsemblGenomes-Gn:BSU04020" /db_xref="EnsemblGenomes-Tr:CAB12210" /db_xref="GOA:O31482" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12782" /db_xref="UniProtKB/Swiss-Prot:O31482" /translation="MFPKPLVILAHEIYGVNSHMKKMGRLIKMAGYDVLTPNLLGEDE VYTLKEEKTAYEQFTKHERLKTGETIIQNVIRQNAGRHIFVIGFSVGATIAWKCSSMP EVSGSVCYYGSRIRDSLHHMPACPVLLFFPNYEPSFDVALLIKKLREKQHTHLEIYQF DALHGFANPDSVYFNRALFFKTLSIIKNGAESRLRTVSSSFF*" /label="yczH CDS" gene complement(436219..436827) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /label="yczH gene" misc_feature complement(436845..436864) /Source="Nicolas_upshift_promotors" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 436861..436867 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(436868) /Source="Nicolas_upshifts" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 436880..436899 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 436886 /Source="Nicolas_upshifts" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="upshifts" CDS 436913..437305 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16291680, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacyl-(acyl carrier protein) dehydratase" /protein_id="NP_388285.2" /db_xref="EnsemblGenomes-Gn:BSU04030" /db_xref="EnsemblGenomes-Tr:CAB12211" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11225" /db_xref="UniProtKB/Swiss-Prot:P42961" /translation="MNSLSLPHRYPFLFIDGVTDSEPGKHAAAYKLISENDWFITDTQ TEMPFSLVIEALAQTAAFTGITDENSLGLLSSVKKAEKLGEAVPGDRLDLTFEVTRNR RGFVFGHAKASVGEQPVAEAEIGIYIEK*" /label="ycsD CDS" gene 436913..437305 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /label="ycsD gene" downshifts 437282 /Source="Nicolas_upshifts" /id="D180" /incds=0 /nref=23 /ntot=189 /MaxReadThrough="1.8721" /MaxDrop="3.42324" /score="-5.4921522" /energy="-13.6" /TU="NA" /idTUdmin="U310" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(437338..437502) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097679.1" /db_xref="EnsemblGenomes-Gn:BSU04039" /db_xref="EnsemblGenomes-Tr:CAX52550" /db_xref="UniProtKB/Swiss-Prot:C0H3V3" /translation="MTEKKQQNKPNENPEHNDLTDPIPNEELKENMNDEKHKRQQRDN SQSERDYDTK*" /label="yczO CDS" gene complement(437338..437502) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /label="yczO gene" downshifts complement(437358) /Source="Nicolas_upshifts" /id="D181" /incds=0 /nref=101 /ntot=193 /MaxReadThrough="1.44096" /MaxDrop="6.55741" /score="22.582242" /energy="-10.6" /TU="NA" /idTUdmin="U313" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(437512..437530) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(437534) /Source="Nicolas_upshifts" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(437545..437551) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 437564..437571 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 437585..437604 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 437588 /Source="Nicolas_upshifts" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="upshifts" CDS 437635..438384 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /EC_number="3.1.3.-" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 26316208, 27435445, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase / 5' nucleotidase" /protein_id="NP_388286.2" /db_xref="EnsemblGenomes-Gn:BSU04040" /db_xref="EnsemblGenomes-Tr:CAB12212" /db_xref="GOA:P42962" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11226" /db_xref="UniProtKB/Swiss-Prot:P42962" /translation="MSVQREDVDIKLIAIDMDGTLLNDEQLISDENRKAIREAEDKGV YVVISTGRTLMTCRELAESLKLSSFLITANGSEIWDSNFNLVERKLLHTDHIQMMWDL RNKHNTNFWASTVNKVWRGEFPENITDHEWLKFGFDIEDDDIRNEVLEELRKNKELEI TNSSPTNIEVNALGINKAAALAKVTEKLGFTMENVMAMGDSLNDIAMIKEAGLGVAMG NAQDIVKETADYITDTNIEDGVAKAIRHWVL*" /label="ribZ CDS" gene 437635..438384 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /label="ribZ gene" downshifts 438361 /Source="Nicolas_upshifts" /id="D182" /incds=0 /nref=219 /ntot=253 /MaxReadThrough="3.23506" /MaxDrop="6.84998" /score="19.5535298" /energy="-11.7" /TU="NA" /idTUdmin="U314" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts complement(438437) /Source="Nicolas_upshifts" /id="D183" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="0.52326" /MaxDrop="2.84763" /score="25.9755124" /energy="-11.7" /TU="NA" /idTUdmin="U313" /TUdmin="-1079" /isTUend="FALSE" /label="downshifts" promotor_-35 438467..438473 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 438487..438506 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 438493..438589 /Source="Nicolas_S_feature" /locus_tag="new_456926_457022" /HighExp="S1, Cold, S0, GM 5, BMM, MG 25, Lbtran, aero, GM 10, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S134" upshifts 438493 /Source="Nicolas_upshifts" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 438590..439363 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxoprolinase subunit A" /protein_id="NP_388287.3" /db_xref="EnsemblGenomes-Gn:BSU04050" /db_xref="EnsemblGenomes-Tr:CAB12213" /db_xref="GOA:P42963" /db_xref="InterPro:IPR005501" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG11227" /db_xref="UniProtKB/Swiss-Prot:P42963" /translation="MFQIDLNCDLGESFGAYKIGLDQDILEYVTSANIACGFHAGDPS VMRKTVALAAERGVKMGAHPGLPDLLGFGRRNMAISPEEAYDLVVYQIGALSGFLKAE GLHMQHVKPHGALYNMAAVDQKLSDAIAKAVYKVDPGLILFGLAESELVKAGERIGLQ TANEVFADRTYQSDGTLTPRSQPDALIESDDAAVTQVIKMVKEGAVKSQQGHDVSLKA DTVCIHGDGAHALTFAQKIRKQLKAAGIEVTAISEQRST*" /label="pxpA CDS" gene 438590..439363 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /label="pxpA gene" CDS 439378..440592 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9334321, 15849754, 16850406, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-oxoproline transporter" /protein_id="NP_388288.3" /db_xref="EnsemblGenomes-Gn:BSU04060" /db_xref="EnsemblGenomes-Tr:CAB12214" /db_xref="GOA:P42964" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG11228" /db_xref="UniProtKB/Swiss-Prot:P42964" /translation="MEQQKKTAGKKAGSWSLLMGAAFLMATSAIGPGFLTQTATFTNT LAASFGFVILISIILDIFAQTNVWRIIAVSGKRGQEIANMVLPGLGYFIAILVVLGGL AFNIGNIGGAGLGLQVLFGITPETGALISAVIAILIFVIKEAGKAMDRFTQIAGFVMI ILTVYVAATTAPPVGQAVANTFVPEHISIFAIVTLVGGTVGGYITFAGGHRLLDAGIK GKESIPQVTKSSVVGILITSVMRIALFLAVLGVVSKGLHIDESNPAASVFKLAAGNVG YKIFGLIMWSAAITSVIGAAYTSVSFFKTFSPKIEKNSRGIIIGFIVVSTLAFVTIGQ PAKILVLVGSLNGLILPIALGTLLVAAYKKNIVGDYKHPLWLTSTGALVVIVMAVMGI YTLCTQLPQLWS*" /label="pxpG CDS" gene 439378..440592 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /label="pxpG gene" CDS 440616..441389 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8186229, 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative D-5-oxoproline epimerase" /protein_id="NP_388289.3" /db_xref="EnsemblGenomes-Gn:BSU04070" /db_xref="EnsemblGenomes-Tr:CAB12215" /db_xref="GOA:P42966" /db_xref="InterPro:IPR009906" /db_xref="InterPro:IPR016938" /db_xref="SubtiList:BG11230" /db_xref="UniProtKB/Swiss-Prot:P42966" /translation="MAPKDVRALIREGKINGPTAGMSGGYAQANLVVLKKDLAFDFLL FCQRNQKPCPVLDVTEAGSPVPSLAAPDADIRTDFPKYRIYRHGILTEEVSDITPYWE DDFVGFLIGCSFSFEQALINNGIAVRHIDEGTNVSMYKTNIDCVPAGAFHGQMVVSMR PVPERLAVRAAQVTSRFPAVHGGPIHIGNPGAIGIRDLGKPDFGDAVSIRDGEVPVFW ACGVTPQAVAMNVKPEMVITHAPGHMLITDIRDESLAVL*" /label="pxpI CDS" gene 440616..441389 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /label="pxpI gene" CDS 441434..442156 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /EC_number="3.5.2.9" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit B" /protein_id="NP_388290.2" /db_xref="EnsemblGenomes-Gn:BSU04080" /db_xref="EnsemblGenomes-Tr:CAB12216" /db_xref="GOA:P60495" /db_xref="InterPro:IPR003833" /db_xref="InterPro:IPR010016" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR029000" /db_xref="PDB:2KWA" /db_xref="PDB:2ZP2" /db_xref="SubtiList:BG11231" /db_xref="UniProtKB/Swiss-Prot:P60495" /translation="MTVRYQIEQLGDSAMMIRFGEEINEQVNGIVHAAAAYIEEQPFP GFIECIPAFTSLTVFYDMYEVYKHLPQGISSPFESVKRDVEERLAEIAEDYEVNRRIV EIPVCYGGEFGPDLEEVAKINQLSPEEVIDIHTNGEYVVYMLGFAPGFPFLGGMSKRI AAPRKSSPRPSIPAGSVGIAGLQTGVYPISTPGGWQLIGKTPLALFRPQENPPTLLRA GDIVKFVRISEKDYHAYKEESN*" /label="pxpB CDS" gene 441434..442156 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /label="pxpB gene" CDS 442159..443166 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit C" /protein_id="YP_054571.2" /db_xref="EnsemblGenomes-Gn:BSU04090" /db_xref="EnsemblGenomes-Tr:CAE01447" /db_xref="GOA:Q7WY77" /db_xref="InterPro:IPR003778" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG14193" /db_xref="UniProtKB/Swiss-Prot:Q7WY77" /translation="MKVLKPGLLTTVQDIGRTGYQKYGVLASGAMDTVSLRIANLLIG NGENEAGLEITMMGPGPSFHFSKQTLIAVTGADFTLRINDEEAPLWKPVLIKENSTVS FGPCKLGSRAYLAAAGGIEVPAVMESKSTYVRGSIGGLHGRALQKEDELNIGEMSALS QTILSRLSSQLGKQGFAAPKWSVSRGRFLPLKKNPVIRVLEGKQFAFFTEESKTRFYE EAFRVTPQSDRMGYRLKGEPLELKAPLEMVSEAVSFGTVQVPPDGNPIILLADRQTTG GYPRIAHIISADLPIVSQIMPGEHVQFEPVSLQEAEALAVEREQHIKELKTRMKMEWL T*" /label="pxpC CDS" gene 442159..443166 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /label="pxpC gene" downshifts 442652 /Source="Nicolas_upshifts" /id="D184" /incds=1 /nref=6 /ntot=27 /MaxReadThrough="5.04721" /MaxDrop="4.5277" /score="-7.2426149" /energy="-12.4" /TU="U315" /idTUdmin="U315" /TUdmin="-1975" /isTUend="FALSE" /label="downshifts" promotor_no_box 442746..442846 /Source="Nicolas_upshift_promotors" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 442806 /Source="Nicolas_upshifts" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 443182..443934 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9334321; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the pxp operon (IclR family)" /protein_id="NP_388291.2" /db_xref="EnsemblGenomes-Gn:BSU04100" /db_xref="EnsemblGenomes-Tr:CAB12217" /db_xref="GOA:P42968" /db_xref="InterPro:IPR005471" /db_xref="InterPro:IPR014757" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11214" /db_xref="UniProtKB/Swiss-Prot:P42968" /translation="MQNKNKTVVKSMALLNLFLHKPSLTLSELVSLTGMPKTSVHRMV SSLEEMGFLSRDASGAYSLGLVFLEFGQLVADRLDIRKIAKPVMEELCREVDEAVQLI MRDGNEAIYVEKIEGTQTVRLYTAIGRRSPLYAGACARSILSFLPREEIEAYIKQTEL ISIGSGTITDPEKLLQEIDASVQNGYTVSYSELENYTAAIGAPIFNHERQVAAGISIA GFEARFTEDRLPYLTEKVKDAALQISRKIGYT*" /label="pxpR CDS" gene 443182..443934 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /label="pxpR gene" promotor_-35 443932..443941 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 443955..443974 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 443965 /Source="Nicolas_upshifts" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 443998..444639 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /EC_number="3.1.1.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 17220230, 20057119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 17220230, 20057119; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat phospholipase B" /protein_id="NP_388292.1" /db_xref="EnsemblGenomes-Gn:BSU04110" /db_xref="EnsemblGenomes-Tr:CAB12218" /db_xref="GOA:P42969" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11232" /db_xref="UniProtKB/Swiss-Prot:P42969" /translation="MVLRYTALGDSLTTGRGSGLFSPGFVQRFGDMMEADLKTRTAIN IFARSGLNTEEILGLLSYPYVQKCIRDADMITITGCGNDLIDSVLAYQTSKDETIFSR VSAHCHENFEKMIAKVAEIKGENPSPYAIRVFNLYNPFPEIDIAGKWITSFNSHLETL ASAPHVKIADAYSIFKGKEQEYLSFDGVHPNSKGYQAMAEAVHKLGYKELSVS*" /label="lipC CDS" gene 443998..444639 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /label="lipC gene" downshifts 444625 /Source="Nicolas_upshifts" /id="D185" /incds=0 /nref=106 /ntot=223 /MaxReadThrough="0.550230000000001" /MaxDrop="6.63515" /score="26.7371783" /energy="-11.8" /TU="NA" /idTUdmin="U315" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(444637..445062) /Source="Nicolas_S_feature" /locus_tag="new_463070_463495_c" /HighExp="S1, Sw, BC, S2, Lbtran, M0t90, LPhT, BI, M40t45, C90" /AntisenseName="yczI" /AntisenseCor="-0.57558682544748696" /AntisenseRegPval="-24.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S135" downshifts complement(444682) /Source="Nicolas_upshifts" /id="D186" /incds=0 /nref=171 /ntot=252 /MaxReadThrough="1.91715" /MaxDrop="5.13764" /score="6.4765859" /energy="-11.8" /TU="NA" /idTUdmin="U319" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 444715..444721 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 444735..444754 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 444736 /Source="Nicolas_upshifts" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="upshifts" CDS 444812..445057 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388293.1" /db_xref="EnsemblGenomes-Gn:BSU04120" /db_xref="EnsemblGenomes-Tr:CAB12219" /db_xref="GOA:P42970" /db_xref="InterPro:IPR025018" /db_xref="SubtiList:BG12783" /db_xref="UniProtKB/Swiss-Prot:P42970" /translation="MFRIFKMSFAVIIIILALIAFNYTEHTSVIQSVMLVFLGAVMFM QGLEERKKENDGSGAFNIYTAVFVWSVSLIGFTLHII*" /label="yczI CDS" gene 444812..445057 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /label="yczI gene" S_feature 445058..445468 /Source="Nicolas_S_feature" /locus_tag="new_463491_463901" /HighExp="T5.0H, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, M9-stat, T-4.40H, T-3.40H" /AntisenseName="yczJ" /AntisenseCor="-0.20847541933848601" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S136" CDS complement(445063..445350) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388294.1" /db_xref="EnsemblGenomes-Gn:BSU04130" /db_xref="EnsemblGenomes-Tr:CAB12220" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12784" /db_xref="UniProtKB/Swiss-Prot:O31484" /translation="MVREAAMLHIKEGLEQEFEDAFRQAAPIISGMKGYITHSLSKCM EETHKYLLLVEWETLEDHTEGFRGSSEYQEWKALLHRFYTPFPTVEHFQDV*" /label="yczJ CDS" gene complement(445063..445350) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /label="yczJ gene" misc_feature complement(445371..445390) /Source="Nicolas_upshift_promotors" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(445387) /Source="Nicolas_upshifts" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 445444..445448 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 445465..445484 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 445470 /Source="Nicolas_upshifts" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="upshifts" CDS 445501..447507 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8830698, 10648534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830698, 10648534; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="penicillin-binding lipoprotein 3; transpeptidase" /protein_id="NP_388295.1" /db_xref="EnsemblGenomes-Gn:BSU04140" /db_xref="EnsemblGenomes-Tr:CAB12221" /db_xref="GOA:P42971" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR007887" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR032710" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11234" /db_xref="UniProtKB/Swiss-Prot:P42971" /translation="MLKKCILLVFLCVGLIGLIGCSKTDSPEDRMEAFVKQWNDQQFD DMYQSLTKDVKKEISKKDFVNRYKAIYEQAGVKNLKVTAGEVDKDDQDNKTMKHIPYK VSMNTNAGKVSFKNTAVLKLEKTDDEESWNIDWDPSFIFKQLADDKTVQIMSIEPKRG QIYDKNGKGLAVNTDVPEIGIVPGELGDKKEKVIKELAKKLDLTEDDIKKKLDQGWVK DDSFVPLKKVKPDQEKLVSEATSLQGVTRTNVSSRYYPYGEKTAHLTGYVRAITAEEL KKKKEGTYSDTSNIGIAGLENVYEDKLRGTTGWKIYVPQTGEVIAEKKAKDGEDLHLT IDIKTQMKLYDELKDDSGAAVALQPKTGETLALVSAPSYDPNGFIFGWSDKEWKKLNK DKNNPFSAKFNKTYAPGSTIKPIAAAIGIKNGTLKADEKKTIKGKEWQKDSSWGGYSV TRVSERLQQVDLENALITSDNIYFAQNALDMGADTFTKGLKTFGFSEDVPYEFPIQKS SIANDKLDSDILLADTGYGQGQMQMSPLHLATAYTPFVDNGDLVKPTLIKKDSQTADV WHKQVVTKEGAADITKGLKGVVEDERGSAYQPVVKGITVAGKTGTAELKTSKDDKDGT ENGWFVGYDYENKDLLVAMMIQNVQDRGGSHYVVEKAKKQFQSN*" /label="pbpC CDS" gene 445501..447507 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /label="pbpC gene" S_feature 447508..447608 /Source="Nicolas_S_feature" /locus_tag="new_465941_466041" /HighExp="LBGstat, T5.0H, M0t45, T3.30H, S0, LBGtran, Oxctl, T4.0H, C30, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.946, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S137" CDS 447609..448511 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388296.1" /db_xref="EnsemblGenomes-Gn:BSU04150" /db_xref="EnsemblGenomes-Tr:CAB12222" /db_xref="GOA:P42972" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11235" /db_xref="UniProtKB/Swiss-Prot:P42972" /translation="MQRIQLAEDLQFSRVIHGLWRLNEWNYSDAELLSLIEWCIDHGI TTFDHADIYGGYTCEKLFGNALALSPGLRENIELVTKCGIVLESPERPAHRSHHYNTS KSHILASVEQSLMNLRTDYIDMLLIHRPDPLMDPEGVAEAFQALKCSGKVRYFGVSNF KDHQYRMLESYLPEKLVTNQIELSAYELENMLDGTLNLCQEKRIPPMAWSPLAGGKVF TENTDKDRRVRTALESVQGEIGAASLDEVMYAWLYTHPAGIMPIVGSGKRERISAAIN ALSYKLDQDQWFRIFTAVQGYDIP*" /label="ycsN CDS" gene 447609..448511 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /label="ycsN gene" downshifts 448491 /Source="Nicolas_upshifts" /id="D187" /incds=0 /nref=48 /ntot=206 /MaxReadThrough="3.20352" /MaxDrop="4.57855" /score="1.36962171" /energy="-10.6" /TU="U320" /idTUdmin="U318" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 448584..448591 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 448605..448624 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 448609..448696 /Source="Nicolas_S_feature" /locus_tag="new_467042_467129" /HighExp="S0, Gly, BC, Lbstat, S2, M9-stat, G135, dia5, T0.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S138" upshifts 448609 /Source="Nicolas_upshifts" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="upshifts" CDS 448697..450781 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188, 24196428, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188, 24196428, 26159071; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, PTS-dependent activator" /protein_id="NP_388297.1" /db_xref="EnsemblGenomes-Gn:BSU04160" /db_xref="EnsemblGenomes-Tr:CAB12223" /db_xref="GOA:P96574" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG12049" /db_xref="UniProtKB/Swiss-Prot:P96574" /translation="MYMTAREQKLLKHLLLQNRYITVTELAELMQVSTRTIHRELKSI KPLMETVGLTLDKQPGKGLKAVGSPEGKQKLLTDLSYEQHEYSADERKLLILCSLLES QEPVKLYTLAHDLQVTNATVSYDLDELEKWISPFGLTLIRKRGFGIQLIGPENAKRKI VGNLIVNRLDIQMFLEAVELNIKGKTDSSEKMFGVVSKGELLKMERILFQLKEKIAFS LSDSSYIALVVHLTYAIERIKLGETITMEQNELEELMNAKEYSSALEIAGELERAFGV TIPEAEVGYITIHLRSANRKYKTEYKAQEIELETALQTKRLIAFISDKIRMDLTKNYS LYEGLIAHLEPAVSRIKENIEIYNPMKEQIKRDYFLLYMAIEEGVEKYFPGMSFSDDE IAFIVLHFGSALEIKKEEAKVKALVVCSSGIGSSKMLASRLKKELPEIESFDMSSLIE LKGKDVQAYDMIVSTVPIPYENIDYIMVSPLLNEEDANQVKQYIKRKIPLILNKKRSS KEEAQQADVPDMLEAAESIGRYMEVIQDVLRHFTLAQLKTNPDHSMLLLELFQQLKKD GLIRDPEKAAVCLAEREKQGGLGIPGTNMALYHLKNDEIVLPFFKMFDLSTPYEVDGM DGNTLRMTRILVMMAPGSLSAEGSEILSAISSAIIESGESMAGFQEEGGQELYQRLNR IFFTWMKEKNIL*" /label="mtlR CDS" gene 448697..450781 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /label="mtlR gene" downshifts 450768 /Source="Nicolas_upshifts" /id="D188" /incds=0 /nref=107 /ntot=220 /MaxReadThrough="1.91059" /MaxDrop="5.63565" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U321" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 450810..450816 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 450830..450848 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 450842 /Source="Nicolas_upshifts" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="upshifts" S_feature 450853..450934 /Source="Nicolas_S_feature" /locus_tag="new_469286_469367" /HighExp="Etha, S5, S6, ferm, S8, nit, S7, BT, Salt, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S139" promotor_-35 450896..450903 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 450917..450936 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 450936 /Source="Nicolas_upshifts" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="upshifts" CDS 450993..452504 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA ligase" /protein_id="NP_388298.2" /db_xref="EnsemblGenomes-Gn:BSU04170" /db_xref="EnsemblGenomes-Tr:CAB12224" /db_xref="GOA:P96575" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG12050" /db_xref="UniProtKB/Swiss-Prot:P96575" /translation="METLQHLILHDMPNSEEIEAVKSGDHTLTYKGYRKRINQLANAM LQKGIQKGDRVALLCKNGHPASTVMFAALEIGAVVVPVSWQLKPYEMTGILKASEPKA MFYGAEFKEILDEVLPELSSLCVTMETGTAYETSAEFEALFAGPDHLPETEMVSPDDT ALLMFTSGTTGNPKRCMITHGGIYRYVKKSNSSIARMKGLRFLACHPIYHTSALICIM LGTFAETTFVFTKDQDPVHMLKVIEEEKIQTVMALPVFYTYLLEAWEKHQTDLSSLVI LMTGGTKVPSSLISRYLDIGIPLAHGYGSTEAWGISTWTPDMGMDKAASAGKPVAGVK VKVEDPLTGEELPQGEIGEIVVHTPFLFKGYEDNPEATAKVLQNGWFRTGDSGYVDED GFIFITGRYKDVIIYGGDNVYPDQVEEVIQQIPGILETAVVGIPDPLYGEKPKAFIVK NGGQRITEEDVIAFCKERLSAYKIPEVEFVNELPKNNLGKVKKDVLRNQAVHS*" /label="ydaB CDS" gene 450993..452504 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /label="ydaB gene" downshifts 452488 /Source="Nicolas_upshifts" /id="D189" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.57376" /MaxDrop="3.70168" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U323" /TUdmin=73 /isTUend="FALSE" /label="downshifts" CDS complement(452524..453069) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388299.1" /db_xref="EnsemblGenomes-Gn:BSU04180" /db_xref="EnsemblGenomes-Tr:CAB12225" /db_xref="GOA:P96576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12051" /db_xref="UniProtKB/Swiss-Prot:P96576" /translation="MIAGYIMAAENQTLNQWTINQLGITRGDSILEVGFGPGYCMQQM LKREKDVHLHGIDVSEAMLKLAARRVKPKGVRLIQGSIETFPLPASFYDKVISVNNYT IWNDQTKGIKQIYRALKPGGKAAITMQPREADASPEKTKSFGRQMIADFKAAGFEDID IQFKNIKPELSVCATAKKPAT*" /label="ydaC CDS" gene complement(452524..453069) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /label="ydaC gene" downshifts complement(452557) /Source="Nicolas_upshifts" /id="D190" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="1.44039" /MaxDrop="3.73662" /score="-9.35066962" /energy="-11.5" /TU="NA" /idTUdmin="U324" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(453136..453154) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(453150) /Source="Nicolas_upshifts" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(453169..453175) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 453211..453217 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-35" upshifts 453229 /Source="Nicolas_upshifts" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="upshifts" promotor_-10 453232..453250 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-10" CDS 453276..454136 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528, 21520290, 28197687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_388300.1" /db_xref="EnsemblGenomes-Gn:BSU04190" /db_xref="EnsemblGenomes-Tr:CAB12226" /db_xref="GOA:P80873" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12052" /db_xref="UniProtKB/Swiss-Prot:P80873" /translation="MANYPKELPAQTQSRQPGIESEMNPSPVYEYEDYKGADKLKGKV ALITGGDSGIGRAVSVAYAKEGADIAIVYKDEHEDAEETKKRVEQEGVKCLLIAGDVG EEEFCNEAVEKTVKELGGLDILVNNAGEQHPKESIKDITSEQLHRTFKTNFYSQFYLT KKAIDYLKPGSAIINTTSINPYVGNPTLIDYTATKGAINAFTRTMAQALVKDGIRVNA VAPGPIWTPLIPATFPEETVAQFGQDTPMGRPGQPVEHVGCYVLLASDESSYMTGQTL HVNGGNFVTT*" /label="ydaD CDS" gene 453276..454136 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /label="ydaD gene" CDS 454152..454655 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /EC_number="5.3.1.15" /experiment="publication(s) with functional evidences, PMID:10220166, 15805528, 21421786, 21520290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15805528, 21421786, 21520290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lyxose ketol isomerase" /protein_id="NP_388301.1" /db_xref="EnsemblGenomes-Gn:BSU04200" /db_xref="EnsemblGenomes-Tr:CAB12227" /db_xref="GOA:P96578" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:2Y0O" /db_xref="SubtiList:BG12053" /db_xref="UniProtKB/Swiss-Prot:P96578" /translation="MGITKEEVNSYYQKAGIVLTDEEVDQIQLMDYGLGKERKVGLQL FVYVNTDRYCSKELVLFPGQTCPEHRHPPVDGQEGKQETFRCRYGKVYLYVEGEKTPL PKVLPPQEDREHYTVWHEIELEPGGQYTIPPNTKHWFQAGEEGAVVTEMSSTSTDKHD IFTDPRI*" /label="lyxE CDS" gene 454152..454655 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /label="lyxE gene" downshifts 454636 /Source="Nicolas_upshifts" /id="D191" /incds=0 /nref=16 /ntot=26 /MaxReadThrough="4.81615" /MaxDrop="6.21035" /score="29.8440619" /energy="-15.5" /TU="U325" /idTUdmin="U325" /TUdmin="-683" /isTUend="FALSE" /label="downshifts" promotor_-35 454684..454691 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 454705..454724 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 454707 /Source="Nicolas_upshifts" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="upshifts" CDS 454741..455292 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /EC_number="2.3.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15468321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal protein N-acetyltransferase" /protein_id="NP_388302.1" /db_xref="EnsemblGenomes-Gn:BSU04210" /db_xref="EnsemblGenomes-Tr:CAB12228" /db_xref="GOA:P96579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1NSL" /db_xref="SubtiList:BG12054" /db_xref="UniProtKB/Swiss-Prot:P96579" /translation="MFTCKVNEHITIRLLEPKDAERLAELIIQNQQRLGKWLFFAENP SSADTYRETIIPDWRRQYADLNGIEAGLLYDGSLCGMISLHNLDQVNRKAEIGYWIAK EFEGKGIITAACRKLITYAFEELELNRVAICAAVGNEKSRAVPERIGFLEEGKARDGL YVNGMHHDLVYYSLLKREWEGEK*" /label="ydaF CDS" gene 454741..455292 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /label="ydaF gene" promotor_-35 455307..455313 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 455328..455346 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 455341 /Source="Nicolas_upshifts" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="upshifts" CDS 455370..455792 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_388303.1" /db_xref="EnsemblGenomes-Gn:BSU04220" /db_xref="EnsemblGenomes-Tr:CAB12229" /db_xref="GOA:P80238" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG19017" /db_xref="UniProtKB/Swiss-Prot:P80238" /translation="MNQQDIKQKVLDVLDHHKVGSLATVQKGKPHSRYMTFFHDGLTI YTPTSKETHKAEEIENNPNVHILLGYDCEGFGDAYVEVAGKAKINNSAELKDKIWSSK LERWFDGKDDPNLVILEIEPEDIRLMNAGEKTPVSLEL*" /label="ydaG CDS" gene 455370..455792 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /label="ydaG gene" promotor_-35 455797..455805 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 455816..455835 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 455835..456201 /Source="Nicolas_S_feature" /locus_tag="new_474268_474634" /HighExp="Etha, Salt, Cold, Sw, B60, Gly, M9-stat, LPhT, B36, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.999, 1" /TUlongSig="SigB" /TUlongPSig=1 /label="S140" upshifts 455835 /Source="Nicolas_upshifts" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(455861..455961) /Source="Nicolas_upshift_promotors" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" misc_RNA complement(455896..456164) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /product="small regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 23457461" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 23457461; Product type n: RNA" /label="bsrC RNA" gene complement(455896..456164) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /label="bsrC gene" upshifts complement(455901) /Source="Nicolas_upshifts" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 456158 /Source="Nicolas_upshifts" /id="D192" /incds=0 /nref=124 /ntot=275 /MaxReadThrough="2.67264" /MaxDrop="7.35087" /score="29.9942993" /energy="-12" /TU="NA" /idTUdmin="U326" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 456238..456247 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 456260..456275 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 456265 /Source="Nicolas_upshifts" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="upshifts" CDS 456298..457107 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_388304.1" /db_xref="EnsemblGenomes-Gn:BSU04230" /db_xref="EnsemblGenomes-Tr:CAB12230" /db_xref="GOA:P96581" /db_xref="InterPro:IPR021260" /db_xref="SubtiList:BG12055" /db_xref="UniProtKB/Swiss-Prot:P96581" /translation="MHVITTQVLFIFCFLLLIHSIETLAYATRLSGARVGFIASALSL FNVMVIVSRMSNMVQQPFTGHLIDDAGKNALAIVGEQFRFLIFGSTVGTILGIILLPS FVALFSRAIIHLAGGGGSVFQVFRKGFSKQGFKNALSYLRLPSISYVKGFHMRLIPKR LFVINMLITSIYTIGVLSALYAGLLAPERSTTAVMASGLINGIATMLLAIFVDPKVSV LADDVAKGKRSYIYLKWTSVTMVTSRVAGTLLAQLMFIPGAYYIAWLTKWF*" /label="amj CDS" gene 456298..457107 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /label="amj gene" downshifts 457088 /Source="Nicolas_upshifts" /id="D193" /incds=0 /nref=5 /ntot=103 /MaxReadThrough="2.92236" /MaxDrop="3.54247" /score="15.7032536" /energy="-14.9" /TU="U330" /idTUdmin="U327" /TUdmin=911 /isTUend="FALSE" /label="downshifts" CDS complement(457151..457441) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388305.1" /db_xref="EnsemblGenomes-Gn:BSU04240" /db_xref="EnsemblGenomes-Tr:CAB12231" /db_xref="GOA:O31485" /db_xref="InterPro:IPR023845" /db_xref="SubtiList:BG12807" /db_xref="UniProtKB/Swiss-Prot:O31485" /translation="MLHTPIGRLRTMGFIEGMSLLILLFIAMPLKYWAGLPLAVTIVG SVHGGLFILYLLVLAYATFSVKWPLKWSAAGFIAAFVPFGNFLYDRGLRNYK*" /label="ydzA CDS" gene complement(457151..457441) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /label="ydzA gene" downshifts complement(457155) /Source="Nicolas_upshifts" /id="D194" /incds=0 /nref=235 /ntot=260 /MaxReadThrough="1.23465" /MaxDrop="7.74945" /score="10.1798531" /energy="-14.9" /TU="NA" /idTUdmin="U332" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(457469..457488) /Source="Nicolas_upshift_promotors" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 457469..457487 /Source="Nicolas_upshift_promotors" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 457475 /Source="Nicolas_upshifts" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(457485) /Source="Nicolas_upshifts" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 457563..457570 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 457584..457603 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 457588 /Source="Nicolas_upshifts" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="upshifts" CDS 457626..458060 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9341680, 10606655, 10913073, 12458218, 16407330, 16528101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341680, 10606655, 10913073, 12458218, 16407330, 16528101; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388306.1" /db_xref="EnsemblGenomes-Gn:BSU04250" /db_xref="EnsemblGenomes-Tr:CAB12232" /db_xref="GOA:P96582" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2CFX" /db_xref="SubtiList:BG12056" /db_xref="UniProtKB/Swiss-Prot:P96582" /translation="MKLDQIDLNIIEELKKDSRLSMRELGRKIKLSPPSVTERVRQLE SFGIIKQYTLEVDQKKLGLPVSCIVEATVKNADYERFKSYIQTLPNIEFCYRIAGAAC YMLKINAESLEAVEDFINKTSPYAQTVTHVIFSEIDTKNGRG*" /label="lrpC CDS" gene 457626..458060 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /label="lrpC gene" promotor_-35 458057..458060 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 458069 /Source="Nicolas_upshifts" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 458077..458096 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 458125..460308 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /EC_number="5.99.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16192570, 16556226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase III" /protein_id="NP_388307.1" /db_xref="EnsemblGenomes-Gn:BSU04260" /db_xref="EnsemblGenomes-Tr:CAB12233" /db_xref="GOA:P96583" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005738" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR034144" /db_xref="SubtiList:BG11979" /db_xref="UniProtKB/Swiss-Prot:P96583" /translation="MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDQYIVTWALGH LVTLADPEGYGKEFQSWRLEDLPIIPEPLKLVVIKKTGKQFNAVKSQLTRKDVNQIVI ATDAGREGELVARWIIEKANVRKPIKRLWISSVTDKAIKEGFQKLRSGKEYENLYHSA VARAEADWIVGINATRALTTKFNAQLSCGRVQTPTLAMIAKREADIQAFTPVPYYGIR AAVDGMTLTWQDKKSKQTRTFNQDVTSRLLKNLQGKQAVVAELKKTAKKSFAPALYDL TELQRDAHKRFGFSAKETLSVLQKLYEQHKLVTYPRTDSRFLSSDIVPTLKDRLEGME VKPYAQYVSQIKKRGIKSHKGYVNDAKVSDHHAIIPTEEPLVLSSLSDKERKLYDLIA KRFLAVLMPAFEYEETKVIAEIGGETFTAKGKTVQSQGWKAVYDMAEEDDEQEDDRDQ TLPALQKGDTLAVRTLTETSGQTKPPARFNEGTLLSAMENPSAFMQGEEKGLVKTLGE TGGLGTVATRADIIEKLFNSFLIEKKGQDIFITSKGKQLLQLVPEDLKSPALTAEWEQ KLSAIAAGKLKSAVFIKDMKAYAHQTVKEIKNSSQTFRHDNITGTACPECGKMMLKVN GKRGTMLVCQDRECGSRKTIARKTNARCPNCHKRMELRGQGEGQTFACVCGHREKLSV FEKRKNKDKARATKRDVSSYMKKQNKDEPINNALAEQLKKLGLDK*" /label="topB CDS" gene 458125..460308 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /label="topB gene" downshifts 460291 /Source="Nicolas_upshifts" /id="D195" /incds=0 /nref=133 /ntot=245 /MaxReadThrough="3.22367" /MaxDrop="6.18597" /score="23.5229393" /energy="-10.4" /TU="U334" /idTUdmin="U333" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 460357..460363 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 460378..460396 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 460379..460510 /Source="Nicolas_S_feature" /locus_tag="new_478812_478943" /HighExp="Etha, Salt, Heat, Cold, H2O2, G180, LPhT, Oxctl, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S141" upshifts 460379 /Source="Nicolas_upshifts" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="upshifts" CDS 460511..461599 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15661000, 26078454, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15661000, 26078454, 27897378; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="glycosyl hydrolase lipoprotein" /protein_id="NP_388308.1" /db_xref="EnsemblGenomes-Gn:BSU04270" /db_xref="EnsemblGenomes-Tr:CAB12234" /db_xref="GOA:O31486" /db_xref="InterPro:IPR008928" /db_xref="SubtiList:BG12057" /db_xref="UniProtKB/Swiss-Prot:O31486" /translation="MRHVLIAVILFFLSIGLSAGCAEAGNKTQNQSATEVNASPLQPA EYFIYHNLMNDKGLIKTDFSDQPSYLSESLGLWMEFLLSKNDAPHFQDQYQHLTDSFL MSNHLVTWKIQNGQASGTNALIDDMRIMLSLDQAAAKWGRSDYAQTARDIGTSLKTYN MNNGFFTDFYDSQAASKDVTLSYVMPDALAVLKKNGIIDEETEQRNANVLYSAPLKNG FLPKTYSSETKEYTYDSEINLIDQLYAAWHLPEGDEKASVLADWIKQEFQKNGKLYGR YSAYTKEPAVQYESPSVYALAVLFLTKQHENSSVIKAIYDRMNDFEIHDPVKSYYGGY MSGTQTHSFDNLLPLLAERKLFNENIIQ*" /label="epsJ CDS" gene 460511..461599 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /label="epsJ gene" CDS 461580..462431 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23893111, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111, 27897378; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic-di-GMP receptor" /protein_id="NP_388309.1" /db_xref="EnsemblGenomes-Gn:BSU04280" /db_xref="EnsemblGenomes-Tr:CAB12235" /db_xref="GOA:P96585" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG12058" /db_xref="UniProtKB/Swiss-Prot:P96585" /translation="MKISFSESQKLFAYFSGLIAALSLFIYYVSAQQSEGALILCITF GVIAAGIWFGPIYALAVTLIVLFVLGTLMMFFQTGQTSLFPAEEGLRMLVVWGIALLL FSFISGRIHDITAELRRSMTRLQSEIKSYVAVDRVTGFDNKQRMKLELSEEIKRAERY GNSFVFLLLHMHYFKEFKSLYGEKETDRLFQYVGQQIRTSVRETDKKFRPSDERIGIV LTHTPAEHMPAVLTKLKKQLDTYQLENGKYVSLTFHVCYLPYRNDIQTADQFLEELEN EMMMNEL*" /label="epsK CDS" gene 461580..462431 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /label="epsK gene" CDS 462442..464151 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27897378; Product type ph :phenotype" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388310.1" /db_xref="EnsemblGenomes-Gn:BSU04290" /db_xref="EnsemblGenomes-Tr:CAB12236" /db_xref="GOA:O31487" /db_xref="InterPro:IPR018763" /db_xref="SubtiList:BG12059" /db_xref="UniProtKB/Swiss-Prot:O31487" /translation="MLCVMMLLFSAIASFPVSAQAKDQDAGILIIYSTLDGKESSQVK MLDLLAGHFTSHVTVKKDSDVEASDFKGKDHVIYYGQTKRKLSQKLLSLISGVKKPVV AIGYNAGQISQFSGLSLARKENVFQVHSRSEKADVSLESGLNVLSVSGLKGTALYTFK ADEGTTHSFIWKTKKGNVYIGLTNLLNDNLIVAKQLREAFGEKAGTTLLYLRLEDISP MSDEKLLLQAGTYLHKRHIPFILAVIPVYLNPETGDKVYLSNQPKMVKVLKKLQSMGG SIIVHGYTHAYRYSETGEGFEFWDAKADQPITSGNAEDPPSILEKEQDFPNEQAYHSY LEPFREKEETYTKQKLTRAIEDLTSSGLYPLAFEAPHYTMSEYGYQIASQYFTSIFGQ VQLSSTTWKTSGAPPFVTAPSMLHGMTLYPETIGFVDTSKQNPLGEMEEHISQMIDFE GGVAGGFYHPYLGMKYLPELVDQMERIPDSEWLDLKKTKQTVKTDKVEIHTSGDGTIQ VKNGVSPIYEFFDHHRQTPLEKALWILSAVVLLFVIMFVSYTFYLRATLKKRIFKERR SLG*" /label="ydaL CDS" gene 462442..464151 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /label="ydaL gene" CDS 464144..465406 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /EC_number="2.4.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378, 28296273; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase associated to biofilm formation" /protein_id="NP_388311.1" /db_xref="EnsemblGenomes-Gn:BSU04300" /db_xref="EnsemblGenomes-Tr:CAB12237" /db_xref="GOA:P96587" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12060" /db_xref="UniProtKB/Swiss-Prot:P96587" /translation="MGNTLFFISLSLIWVMLLYHMFLMQGGFRHYMTFERNIPKWREN MKELPKVSVLIPAHNEEVVIRQTLKAMVNLYYPKDRLEIIVVNDNSSDRTGDIVNEFS EKYDFIKMVITKPPNAGKGKSSALNSGFAESNGDVICVYDADNTPEKMAVYYLVLGLM NDEKAGAVVGKFRVINAAKTLLTRFINIETICFQWMAQGGRWKWFKIATIPGTNFAIR RSIIEKLGGWDDKALAEDTELTIRVYNLGYHIRFFPAAITWEQEPETWKVWWRQRTRW ARGNQYVVLKFLAQFFKLKRKRIIFDLFYFFFTYFLFFFGVIMSNAIFVVNLFYDLHL SVGFLAMILWILAFFLFMTEVMITLSIEKTEMNKQNFFIVFLMYFTYSQAWIVLVIYS LFVEIKHRLFKQEVKWYKTERYNQHKSG*" /label="ydaM CDS" gene 464144..465406 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /label="ydaM gene" CDS 465412..467523 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative regulator of exopolysaccharide synthesis" /protein_id="NP_388312.1" /db_xref="EnsemblGenomes-Gn:BSU04310" /db_xref="EnsemblGenomes-Tr:CAB12238" /db_xref="GOA:O31488" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR018513" /db_xref="SubtiList:BG12061" /db_xref="UniProtKB/Swiss-Prot:O31488" /translation="MKQIMIFLTSFMLLAMTGQTALAKDVQVSGSLLGKSSQEQAKQQ VLTSELITLYGSKDSAELTYQIPAGASSGNQQLVIEYEASNLLISPSSLTVVIDDEPV KTLKLDGDSKRKTVKLNLNKSQSAQGYHNVSLKFYGVMKEGVCVRQDTSGNWIKIYPD SRLTLADSSEAKGTSLDHYPYPFAQSGNTAEETAIVIPDNPSSAEIEAAVKTEGYLKT VDSSVSIAYVTESELKKIDKPTIVIGVDKHWNGKVKKLLKQAGLQAKGENLLLAERVL KAEGKQQPVLFAQAASEDALTKKISVMTDQTYTGQLSGDTLSISKLQQTEKKESDKLT LENFGAGDITIGADKTSSAHYFYPASAVLDENQSAKLSLKLKKSETIQASTAENESAS QAAELKVMINGQPHSVRLDELGKEDKNGFYHVTVKVDPKLLQKNRYIDIQFVTTGLKE NNPCNTTDEEKWVFIDKNSTLSYAIKGMSPSADFQEWPLPYAGNQDQTTLIVLPDTVS QSKLEELSLVTESFGNEAQHSYTVKKSSDVTANDAKGRNLIFIGGINQFSLLKEKSSD LLVPQEKNGSFDVSSFEMLNETTKQVVFTQASVWDSRYTMAVFAPSKGDGTAVTKEII SYLNSNDESATVLNETNSQQVFTNHQQLKSETNSSDAEQPTQDHSQKWMYIGVLALIM VVAAVFIWIAVRRKKRKTDTE*" /label="ydaN CDS" gene 465412..467523 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /label="ydaN gene" downshifts 467507 /Source="Nicolas_upshifts" /id="D196" /incds=0 /nref=18 /ntot=91 /MaxReadThrough="0.438479999999999" /MaxDrop="4.36576" /score="34.1370207" /energy="-9.9" /TU="NA" /idTUdmin="U336" /TUdmin="-4598" /isTUend="FALSE" /label="downshifts" promotor_-35 467620..467627 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 467642..467661 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 467649 /Source="Nicolas_upshifts" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 467659..467802 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /product="ATP-, cyclic di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 20511502, 23086297, 25086507, 25086509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 20511502, 23086297, 25086507, 25086509; Product type n: RNA" /function="16.3: Control" /label="swaO RNA" gene 467659..467802 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /label="swaO gene" downshifts 467800 /Source="Nicolas_upshifts" /id="D197" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="7.43698" /MaxDrop="5.83561" /score="30.4392599" /energy="-14.7" /TU="U336" /idTUdmin="U336" /TUdmin="-4305" /isTUend="FALSE" /label="downshifts" S_feature 467845..467998 /Source="Nicolas_S_feature" /locus_tag="new_486278_486431" /HighExp="LPhT, LBGstat, LPh, T-1.10H, T-0.40H, G135, G180, T-1.40H, G150, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S142" CDS 467999..469822 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cyclic di-AMP controlled transporter of potassium" /protein_id="NP_388313.1" /db_xref="EnsemblGenomes-Gn:BSU04320" /db_xref="EnsemblGenomes-Tr:CAB12239" /db_xref="GOA:P96589" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12062" /db_xref="UniProtKB/Swiss-Prot:P96589" /translation="MYHSIKRFLIGKPLKSQAAGEQKLTKLKALAMLSSDALSSVAYG TEQILIILATISAAAFWYSIPIAVGVLILLLALILSYRQIIYAYPQGGGAYIVSKENL GEKPGLIAGGSLLVDYILTVAVSISAGTDAITSAFPALHDYHVPIAIFLVLVIMILNL RGLSESASILAYPVYLFVVALLVLIAVGLFKLMTGQIDQPAHHTSLGTPVAGITLFLL LKAFSSGCSALTGVEAISNAIPAFKNPPARNAARTLAMMGILLAILFSGITVLAYGYG TAPKPDETVVSQIASETFGRNVFYYVIQGVTSLILVLAANTGFSAFPQLAFNLARDQY MPRMFTVRGDRLGFSNGIIFLGFASIVLIILFGGQTEHLIPLYAVGVFIPFTLSQTGM CMKWIKQKPKGWIGKMLINSCGALISFMVLSILFVTKFNVVWPVLIFMPIVVLLFFAI KNHYTAVGEQLRIVDKEPEEIKGTVVIVPVAGVTTVVQKSIHYAKSLSDQVIAVHVSF DREQEKKFEKRWEELNNGVRLVTLHSSYRSLVHPFDKFLETVEAKAKKEQFSVMVLFP QFITKKRWHTILHNQSAFLLRVRLFWKKDIMVATLPYHFKK*" /label="kimA CDS" gene 467999..469822 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /label="kimA gene" downshifts 469814 /Source="Nicolas_upshifts" /id="D198" /incds=0 /nref=50 /ntot=181 /MaxReadThrough="3.55206" /MaxDrop="4.7232" /score="6.00201196" /energy="-13.9" /TU="U336" /idTUdmin="U336" /TUdmin="-2291" /isTUend="FALSE" /label="downshifts" CDS 469881..470330 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /EC_number="3.6.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576788, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NTP pyrophosphohydrolase" /protein_id="NP_388314.1" /db_xref="EnsemblGenomes-Gn:BSU04330" /db_xref="EnsemblGenomes-Tr:CAB12240" /db_xref="GOA:P96590" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11956" /db_xref="UniProtKB/Swiss-Prot:P96590" /translation="MYTQGAFVIVLNESQQILLVKRKDVPLWDLPGGRVDPGESAEEA AVREILEETGYNAALSAKIGVYQRPKFQDEQHLFFGSITGGQAMADGTETAGLKWVSP GRLPLFMVPNRKRQINDFKNGAQDVNVTVKDSGLLAAIDLLKRRLGK*" /label="nudT CDS" gene 469881..470330 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /label="nudT gene" promotor_-35 470343..470349 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 470364..470382 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 470365 /Source="Nicolas_upshifts" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="upshifts" CDS 470397..472121 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /EC_number="1.2.3.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291680, 16513748, 10220166, 23611909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-phosphate generating pyruvate oxidase" /protein_id="NP_388315.1" /db_xref="EnsemblGenomes-Gn:BSU04340" /db_xref="EnsemblGenomes-Tr:CAB12241" /db_xref="GOA:P96591" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12063" /db_xref="UniProtKB/Swiss-Prot:P96591" /translation="MAHKTAGQAMTELLEQWGVDHVYGIPGDSINEFIEELRHERNQL KFIQTRHEEVAALAAAAEAKLTGKIGVCLSIAGPGAVHLLNGLYDAKADGAPVLAIAG QVSSGEVGRDYFQEIKLEQMFEDVAVFNREVHSAESLPDLLNQAIRTAYSKKGVAVLS VSDDLFAEKIKREPVYTSPVYIEGNLEPKKEQLVTCAQYINNAKKPIILAGQGMKKAK RELLEFADKAAAPIVVTLPAKGVVPDKHPHFLGNLGQIGTKPAYEAMEECDLLIMLGT SFPYRDYLPDDTPAIQLDSDPAKIGKRYPVTAGLVCDSALGLRELTEYIERKEDRRFL NACTEHMQHWWNEIEKDETEATTPLKPQQVVARLQEAAADDAVLSVDVGTVTVWMARH FKMNANQDFIVSSWLATMGCGLPGAIAASLSEPERQAIAVCGDGGFSMVMQDLPTAVK YKLPITVVILNNENLGMIEYEQQVKGNIDYVTKLQNVDYAAFAESCGAKGIKVTKAEE LAPAFHEALHSDQPVVVDVMIGNEPPLPGKITYGQAKGFSKYMLKNFFENQKFEMPSL KKSLKRLF*" /label="poxB CDS" gene 470397..472121 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /label="poxB gene" S_feature complement(471233..472092) /Source="Nicolas_S_feature" /locus_tag="new_489666_490525_c" /HighExp="H2O2, Paraq, G180, G150, Oxctl, Diami, dia15, G135, C30, dia5" /AntisenseName="ydaP" /AntisenseCor="-5.0529608261635599E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S143" S_feature complement(472094..472205) /Source="Nicolas_S_feature" /locus_tag="new_490527_490638_c" /HighExp="dia5, M0t45, S0, S2, S1, Paraq, GM 120, Lbstat, MG 5, UNK1" /AntisenseName="ydaP" /AntisenseCor="1.7026698118644101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S144" downshifts 472105 /Source="Nicolas_upshifts" /id="D199" /incds=0 /nref=50 /ntot=166 /MaxReadThrough="5.18566" /MaxDrop="6.66568" /score="7.55338633" /energy="-5.3" /TU="U337" /idTUdmin="U336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(472113..472316) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513943.1" /translation="MIRISMQGQMHLPLKQDAFVLLSVSSMAKSVPNTYTDHFMNSNM LKIHLFPKKKKKTRALRAPVFLK*" /label="hypothetical protein CDS" gene complement(472113..472316) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /label="gene" downshifts complement(472137) /Source="Nicolas_upshifts" /id="D200" /incds=0 /nref=5 /ntot=55 /MaxReadThrough="4.75809" /MaxDrop="8.06239" /score="11.2659249" /energy="-9.1" /TU="U338,U340,U341" /idTUdmin="U338" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_no_box complement(472165..472265) /Source="Nicolas_upshift_promotors" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 472174..472179 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 472196..472214 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(472205) /Source="Nicolas_upshifts" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="upshifts" S_feature 472206..472421 /Source="Nicolas_S_feature" /locus_tag="new_490639_490854" /HighExp="Etha, S4, S8, S5, C30, S7, B60, S6, Salt, B36" /AntisenseName="ydzK" /AntisenseCor="3.8830946787094797E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigB" /TUshortPSig="0.914, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S145" upshifts 472206 /Source="Nicolas_upshifts" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(472272..472343) /Source="Nicolas_S_feature" /locus_tag="new_490705_490776_c" /HighExp="Sw, B60, dia15, dia5, BI, Etha, BC, M9-stat, C90, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S146" downshifts complement(472315) /Source="Nicolas_upshifts" /id="D201" /incds=0 /nref=21 /ntot=191 /MaxReadThrough="5.39949" /MaxDrop="5.81865" /score="3.34912028" /energy="-20.3" /TU="U340,U341" /idTUdmin="U343" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(472344..472610) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_003097680.1" /db_xref="EnsemblGenomes-Gn:BSU04359" /db_xref="EnsemblGenomes-Tr:CAX52551" /db_xref="GOA:C0H3V4" /db_xref="UniProtKB/Swiss-Prot:C0H3V4" /translation="MSVFILFYLWIVPIVIGILCSVAAHKSKGKMRVAPGIAMIVLSI ISLITAFTAGHTNFHVFIGGMFLFGTFLVGSAFPFFFGLKKKEK*" /label="ydzK CDS" gene complement(472344..472610) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /label="ydzK gene" promotor_-10 complement(472626..472645) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(472644) /Source="Nicolas_upshifts" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(472657..472664) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(472714..473991) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton-coupled manganese transporter" /protein_id="NP_388317.1" /db_xref="EnsemblGenomes-Gn:BSU04360" /db_xref="EnsemblGenomes-Tr:CAB12243" /db_xref="GOA:P96593" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG12065" /db_xref="UniProtKB/Swiss-Prot:P96593" /translation="MMNKDITAQSPRSKAVQDALDGKIRGFRGLLPFLGPAFIAAIAY IDPGNFATNISAGSKYGYMLLWVILFSNIMALLIQSLSAKLGIATGKNLPEVAREEFP KPVSIGLWIQGELVIIATDLAEFIGAALGLYLLFGIPMLEASIIAAIGSFAILELQRR GYRSLEAGIAGMLFVVVIAFALQTFFAKPDAVSVMKGLFVPAFHGTDSVLLAAGILGA TVMPHAIYLHSALTQRRVVGKTDAERKKIFRFEFIDILIAMLIAGAINASMLIVAAAL FFKNGLFVEDLDVAFQQFGHLVSPMSAALFGIGLLVAGLSSSSVGTLSGDVIMQGFIN YRIPLYVRRFITIIPPILIIASGVNPTTALVLSQVVLSFGIAFALIPLIMFTSNKRIM GSLINAKWITVVSWLIAVLIVALNVFLIVDTFR*" /label="mntH CDS" gene complement(472714..473991) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /label="mntH gene" downshifts complement(472733) /Source="Nicolas_upshifts" /id="D202" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="5.8826" /MaxDrop="4.8109" /score="28.3182556" /energy="-9.6" /TU="U341,U343" /idTUdmin="U342" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(474053..474072) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(474065) /Source="Nicolas_upshifts" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(474067..474144) /Source="Nicolas_S_feature" /locus_tag="new_492500_492577_c" /HighExp="S6, S8, S7, Etha, S5, Salt, BT, Heat, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="1, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S147" promotor_-35 complement(474085..474092) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(474128..474147) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(474144) /Source="Nicolas_upshifts" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(474161..474170) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(474221..474478) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388318.1" /db_xref="EnsemblGenomes-Gn:BSU04370" /db_xref="EnsemblGenomes-Tr:CAB12244" /db_xref="GOA:P96594" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG12066" /db_xref="UniProtKB/Swiss-Prot:P96594" /translation="MLSFLVSLVVAIVIGLIGSAIVGNRLPGGIFGSMIAGLIGAWIG HGLLGTWGPSLAGFAIFPAIIGAAIFVFLLGLIFRGLRKEA*" /label="ydaS CDS" gene complement(474221..474478) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /label="ydaS gene" downshifts complement(474229) /Source="Nicolas_upshifts" /id="D203" /incds=0 /nref=7 /ntot=33 /MaxReadThrough="4.70076" /MaxDrop="4.7213" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" downshifts complement(474295) /Source="Nicolas_upshifts" /id="D204" /incds=1 /nref=2 /ntot=69 /MaxReadThrough="7.55545" /MaxDrop="2.8244" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" CDS complement(474556..475008) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388319.1" /db_xref="EnsemblGenomes-Gn:BSU04380" /db_xref="EnsemblGenomes-Tr:CAB12245" /db_xref="InterPro:IPR018691" /db_xref="SubtiList:BG12067" /db_xref="UniProtKB/Swiss-Prot:P96595" /translation="MPWSMKDYPASLKNLEKPVRKKAIDIANAMIDEGYEEGRAIPIA TSKAKEWAENASTDEIDDFLTHDDETERDADPSSGSGPELMNKAEHVIKHKKGWAVKA EGAKRVSEIKDTKKEAIERAKEIAAHKGTEVIVHLADGSVQRKIKTGS*" /label="ydaT CDS" gene complement(474556..475008) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /label="ydaT gene" promotor_-10 complement(475027..475045) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(475044) /Source="Nicolas_upshifts" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(475059..475065) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 475077 /Source="Nicolas_upshifts" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 475085..475104 /Source="Nicolas_upshift_promotors" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 475126..475944 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388320.1" /db_xref="EnsemblGenomes-Gn:BSU04390" /db_xref="EnsemblGenomes-Tr:CAB12246" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG12068" /db_xref="UniProtKB/Swiss-Prot:P96596" /translation="MPTERKEDLHQQLKEIEKWEKDQQKVWFWEKLSRLPFQLLDKLT PEFIQKKIGKLLDEVGSFVQTGGQYLTSEKQIIRMFQKKLPEEIFESLEDIRKAPLPV MDEIAEGMGKNRTNAATVQGATTGVGGVFTLAADIPAVLGLSLKTLQDIAVAYGYDPK EKKERVFIVKCLQLTSADVVGKRSILQELKHYDQDRTYKNVASQIQGWREVVLGYRDT FGWKKLFQIVPVAGMVFGAAANRSTLNDITETGMMLYKKRRILERLKETEREME*" /label="ydbA CDS" gene 475126..475944 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /label="ydbA gene" downshifts 475935 /Source="Nicolas_upshifts" /id="D205" /incds=0 /nref=118 /ntot=223 /MaxReadThrough="0.66117" /MaxDrop="4.41502" /score="5.38936313" /energy="-9.2" /TU="NA" /idTUdmin="U344" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 476012..476018 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476032..476050 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476040 /Source="Nicolas_upshifts" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="upshifts" CDS 476073..476444 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651322, 9669336, 9763714, 12562800, 21421783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651322, 9669336, 9763714, 12562800, 21421783; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein glucose starvation induced" /protein_id="NP_388321.1" /db_xref="EnsemblGenomes-Gn:BSU04400" /db_xref="EnsemblGenomes-Tr:CAB12247" /db_xref="InterPro:IPR019626" /db_xref="SubtiList:BG10826" /db_xref="UniProtKB/Swiss-Prot:P26907" /translation="MADNNKMSREEAGRKGGETTSKNHDKEFYQEIGQKGGEATSKNH DKEFYQEIGEKGGEATSKNHDKEFYQEIGEKGGEATSENHDKEFYQEIGRKGGEATSK NHDKEFYQEIGSKGGNARNND*" /label="gsiB CDS" gene 476073..476444 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /label="gsiB gene" downshifts complement(476077) /Source="Nicolas_upshifts" /id="D206" /incds=0 /nref=1 /ntot=25 /MaxReadThrough="1.50212" /MaxDrop="4.6705" /score="-7.76438364" /energy="-14.2" /TU="NA" /idTUdmin="U346" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 476461 /Source="Nicolas_upshifts" /id="D207" /incds=0 /nref=153 /ntot=219 /MaxReadThrough="3.75525" /MaxDrop="8.3301" /score="39.7307477" /energy="-16.6" /TU="U345" /idTUdmin="U345" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" upshifts complement(476495) /Source="Nicolas_upshifts" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(476498..476501) /Source="Nicolas_upshift_promotors" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 476523..476530 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476542..476561 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476549 /Source="Nicolas_upshifts" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="upshifts" CDS 476576..476917 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme; cupin family" /protein_id="NP_388322.1" /db_xref="EnsemblGenomes-Gn:BSU04410" /db_xref="EnsemblGenomes-Tr:CAB12248" /db_xref="GOA:P96597" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR019780" /db_xref="SubtiList:BG12069" /db_xref="UniProtKB/Swiss-Prot:P96597" /translation="MSKMQNLLAIANEVKEKHANFSISEVNDHCVRLAVFTGEYDWHH HPDSDELFIVLEGELLIDFKDKETAVLKANDSLLIPKGTVHRTRSYVRTVNLCVEHKQ AETVIIEEQPC*" /label="ydbB CDS" gene 476576..476917 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /label="ydbB gene" CDS 476911..477270 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388323.1" /db_xref="EnsemblGenomes-Gn:BSU04420" /db_xref="EnsemblGenomes-Tr:CAB12249" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR032555" /db_xref="SubtiList:BG12070" /db_xref="UniProtKB/Swiss-Prot:P96598" /translation="MLIKKMICEVDAANAEAFAKAQSQWEALSHISGFIKQAGGWRKT IDEPLTAEIISVWENREAYDHFMENEHDSIYEENDQKAVILSIEVTVYEEDKPFVHDL LHNPDIRYEPNWTVLKA*" /label="ydbC CDS" gene 476911..477270 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /label="ydbC gene" S_feature complement(476973..477266) /Source="Nicolas_S_feature" /locus_tag="new_495406_495699_c" /HighExp="Etha, Salt, M9-stat, C30, Heat, Sw, B60, S8, C90, UNK1" /AntisenseName="ydbC" /AntisenseCor="0.16172626521480701" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S148" downshifts 477211 /Source="Nicolas_upshifts" /id="D208" /incds=0 /nref=2 /ntot=130 /MaxReadThrough="1.8663" /MaxDrop="2.67081" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 477255 /Source="Nicolas_upshifts" /id="D209" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="0.252220000000001" /MaxDrop="2.61185" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(477307..478128) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /EC_number="1.11.1.6" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15231799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative manganese-containing catalase" /protein_id="NP_388324.1" /db_xref="EnsemblGenomes-Gn:BSU04430" /db_xref="EnsemblGenomes-Tr:CAB12250" /db_xref="GOA:P80878" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR027407" /db_xref="SubtiList:BG12071" /db_xref="UniProtKB/Swiss-Prot:P80878" /translation="MFKHTKMLQHPAKPDRPDPLFAKKMQEILGGQFGEISVAMQYLF QGWNTRGNEKYKDLLMDTATEELGHVEMIATMIARLLEDAPLDQQEKAAEDPVIGSIL GGMNPHHAIVSGLGAMPESSTGVPWSGGYIVASGNLLADFRANLNAESQGRLQVARLF EMTDDKGVKDMLSFLLARDTMHQNQWLAAIKELEAQEGPVVPGTFPKALEKQEFSHQL INFSEGEVSAEQNWLNEKAPDGEAFEYVKEAKTFGEKPELKPAPPFVHNTLPGRE*" /label="ydbD CDS" gene complement(477307..478128) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /label="ydbD gene" downshifts complement(477311) /Source="Nicolas_upshifts" /id="D210" /incds=0 /nref=62 /ntot=214 /MaxReadThrough="4.23505" /MaxDrop="6.82771" /score="-6.55917314" /energy="-13.1" /TU="U348" /idTUdmin="U348" /TUdmin="-310" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(478150..478168) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(478171) /Source="Nicolas_upshifts" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(478182..478188) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(478213..479265) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:1809844, 10708364, 11566984, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1809844, 10708364, 11566984, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane bound C4-dicarboxylate binding sensor protein" /protein_id="NP_388325.1" /db_xref="EnsemblGenomes-Gn:BSU04440" /db_xref="EnsemblGenomes-Tr:CAB12251" /db_xref="GOA:P96600" /db_xref="InterPro:IPR004682" /db_xref="InterPro:IPR018389" /db_xref="SubtiList:BG12072" /db_xref="UniProtKB/Swiss-Prot:P96600" /translation="MKSLLACLALMIAGIATALFIGFHDHTGNKKIVYDDDQEGLQDQ IVFKFSHVVAENTPKGLAANKFADLVNEKSGGKIKIEVFPNGSLYSDIEEIEALQNGD VQFIAPSTSKLGMLSPEWGVLDLPYAFTDYNAVKKGLNGSIGTQLFDSLKKNQLKGLA YWTNGFKQITTNQGPVKTPDDLKGQDLRIMQSDVIEDQFKLLGATPHQESFNSTFQLL ENNVVDGEENTISNIYSKKFYNVQDYLTISSHGYLGYAVMTDEHFWKAQTPETRRILT EAMKETTEWNETYAEQMNKEQLEEIKKNSAIHIYELSDKEKQEWMKRLDPVYRQYEPI FGRELIRELLELRKDS*" /label="dctB CDS" gene complement(478213..479265) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /label="dctB gene" promotor_-35 478525..478532 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 478547..479334 /Source="Nicolas_S_feature" /locus_tag="new_496980_497767" /HighExp="LBGstat, Diami, T-0.40H, T0.0H, T0.30H, Heat, UNK1, GM-0.1, MG 90, Fru" /AntisenseName="dctB" /AntisenseCor="0.64205060306327899" /AntisenseRegPval="-31.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S149" promotor_-10 478547..478566 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 478548 /Source="Nicolas_upshifts" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(479278..479297) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(479283) /Source="Nicolas_upshifts" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(479311..479318) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 479335..480942 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388326.1" /db_xref="EnsemblGenomes-Gn:BSU04450" /db_xref="EnsemblGenomes-Tr:CAB12252" /db_xref="GOA:P96601" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12073" /db_xref="UniProtKB/Swiss-Prot:P96601" /translation="MNKKKLSIRWKITILSYILVIFSFLIGGIVLIGNIQHTEERELK KRLMNTARTVSEMTEVKEALARKKQTEAVRHAVEEIRMINEADYIVVMDMNHIRYTHP VSTSIGKKSEGADEEAAFAEHIYFSEAKGEIGTAVRAFYPVKDQDLNQIGVVLVGKTL PGIADILLHLKRDIAFIVVLTLGFGLAGSFLLARHIKKQMFQLEPHEIVRMYEERTAT FHSMNEGVIAIDNRLVITIFNEKAKQIFEVQGDLIGKVIWEVLKDSRLPEIVERNKAV YNEEIRVSGKVIMSSRIPIVMKKKVIGAVAIFQDRTEAAKMAEELTGVRNFVEALRVQ NHEHMNKLHTIAGLIQLGKSEKALQLAFQASTEQENVTEFLHRSIQNDAAAGLLLSKI RRGRELGIAVHIDENSSLQQFPEHVDQHDIVVLLGNLIENAFGSFETVQSEDKRIDIS IEQTDDILAILIEDNGCGIEPTHMPRLYDKGFTVNKTGGTGYGLYLVKQIIDKGSGTI EVDSHAGQGTSFSIVFPMKGEEAQHGS*" /label="dctS CDS" gene 479335..480942 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /label="dctS gene" CDS 480932..481612 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388327.1" /db_xref="EnsemblGenomes-Gn:BSU04460" /db_xref="EnsemblGenomes-Tr:CAB12253" /db_xref="GOA:P96602" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12074" /db_xref="UniProtKB/Swiss-Prot:P96602" /translation="MARKEWKVLLIEDDPMVQEVNKDFITTVKGVTVCATAGNGEEGM KLIKEEQPDLVILDVYMPKKDGIKTLQEIRKQKLEVDVIVVSAAKDKETISLMLQNGA VDYILKPFKLERMRQALEKYKQYKQKIEANDTLSQEQLDAILNIPQQAVQDLPKGLNH FTMNEVTAFLKQQTASLSAEEVAKALGIARVTARRYLDYLEKTGIIKLDVQYGGVGRP VNRYVLKG*" /label="dctR CDS" gene 480932..481612 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /label="dctR gene" S_feature 481613..481687 /Source="Nicolas_S_feature" /locus_tag="new_500046_500120" /HighExp="Sw, Diami, Mt0, G150, BI, Lbstat, M40t45, Lbtran, Mal, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S150" promotor_-35 481654..481661 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 481676..481693 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 481689 /Source="Nicolas_upshifts" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="upshifts" CDS 481733..482998 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480; Product type t: transporter" /codon_start=1 /transl_table=11 /product="C4-dicarboxylate transport protein" /protein_id="NP_388328.1" /db_xref="EnsemblGenomes-Gn:BSU04470" /db_xref="EnsemblGenomes-Tr:CAB12254" /db_xref="GOA:P96603" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR023954" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12075" /db_xref="UniProtKB/Swiss-Prot:P96603" /translation="MKLFKNLTVQVITAVIIGVIVGLVWPDVGKEMKPLGDTFINAVK MVIAPIIFFTIVLGIAKMGDMKKVGKVGGKAFIYFEVVTTLALIIGLFVVNIMKPGAG LDYSKLEKGDVSQYTQNGGQGIDWIEFITHIVPSNMVDAFAKGDILQVLFFSILFGVG LAALGEKGKSVIDFFDKVSHVFFKIIGYIMRAAPIGAFGAMAYTIGHFGLDSIKPLAS LMMSVYITMFLFVFVALNIICKLYGFSLWNYLRFIKDELLIVLGTSSSESVLPRMMDK MERYGCSKSVVGLVIPTGYSFNLDGTSIYLSMATVFLAQVFGVDLSIGQQITIILVLM LTSKGAAGVTGSGFIVLASTLSALQVIPLEGLALLLGVDRFMSEGRAIVNLIGNGIAT IIVAKSENEFDEAKSIEAVEGMKKMKTAV*" /label="dctP CDS" gene 481733..482998 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /label="dctP gene" downshifts 482991 /Source="Nicolas_upshifts" /id="D211" /incds=0 /nref=175 /ntot=235 /MaxReadThrough="3.99042" /MaxDrop="7.04798" /score="45.0636559" /energy="-12.6" /TU="NA" /idTUdmin="U351" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(483045) /Source="Nicolas_upshifts" /id="D212" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.588190000000001" /MaxDrop="3.06255" /score="19.3433396" /energy="-12.6" /TU="NA" /idTUdmin="U350" /TUdmin="-4818" /isTUend="FALSE" /label="downshifts" misc_feature 483082..483099 /Source="Nicolas_upshift_promotors" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 483084 /Source="Nicolas_upshifts" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 483146..484198 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388329.1" /db_xref="EnsemblGenomes-Gn:BSU04480" /db_xref="EnsemblGenomes-Tr:CAB12255" /db_xref="GOA:P96604" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG12076" /db_xref="UniProtKB/Swiss-Prot:P96604" /translation="MAALVKFFQHPGVRRFSIFVVLTGVLYLFKSMINLILLTFIFTF LMDRLELVVRQFVSQFFRVSQRVVITFLYMLLAVLLTVGGFVFYPVVAAQIQQLVKQI KHIAYHPDSIPFFDEITSVFGDINISSYVKEGFNVVYTYLADISTFGLQVVMALILSM FFLFEKKRLSEFMAKFKTSKLRVFYEEIAFFGSKFARTFGKVLEAQFIIALVNCILTF IALWIMHFPQLFGLSIMVFFLGLIPVAGVVISLIPLSIIAYSTGGGMYVLYIVLVIFA IHAIETYFLNPKLMSAKTELPIFFTFTVLIFSEHFFGIWGLIIGIPIFVFLLDILDVT NKEDRSKGPRENSDKK*" /label="ydbI CDS" gene 483146..484198 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /label="ydbI gene" S_feature 484199..484442 /Source="Nicolas_S_feature" /locus_tag="new_502632_502875" /HighExp="S8, S5, S6, LoTm, S7, S3, LBGstat, LBGexp, Paraq, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.87223499999999998" /TUshortSig="Sig-" /TUshortPSig="0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S151" downshifts 484399 /Source="Nicolas_upshifts" /id="D213" /incds=0 /nref=6 /ntot=45 /MaxReadThrough="6.05001" /MaxDrop="3.52626" /score="17.6400305" /energy="-12.4" /TU="U352" /idTUdmin="U351" /TUdmin=1408 /isTUend="FALSE" /label="downshifts" CDS 484475..485401 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding subunit)" /protein_id="NP_388330.1" /db_xref="EnsemblGenomes-Gn:BSU04490" /db_xref="EnsemblGenomes-Tr:CAB12256" /db_xref="GOA:P96605" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12077" /db_xref="UniProtKB/Swiss-Prot:P96605" /translation="MAEPILHIEGLDKKIGSKQILKQISMDVMEGEIIGLLGPNGSGK TTLIRIIVGLLKQNSGSVTISGFQHDTEFEKAMEAVGAIVENPEFYPYLTGWENLKHF ANMHKKIADERLDEVVERVGLTSAIHDKVKTYSLGMRQRLGIAQAILHRPKLLILDEP TNGLDPAGMKDFRDHIKELAEMEGTAVLFATHLLREVEDLCDRVIIIQKGEIKAEVSL QGTDQTTEKAIIEVQPQEKALNWLTGNQYQAESQDGTIVVEVAKENIPELNRSLVGQD LNVFSITPYTQSLEDEFIKATTAHQEEGEELV*" /label="ydbJ CDS" gene 484475..485401 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /label="ydbJ gene" CDS 485421..486161 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux ABC-transporter (permease subunit)" /protein_id="NP_388331.1" /db_xref="EnsemblGenomes-Gn:BSU04500" /db_xref="EnsemblGenomes-Tr:CAB12257" /db_xref="GOA:P96606" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12078" /db_xref="UniProtKB/Swiss-Prot:P96606" /translation="MKLFNRKVTLVSLILMAVFQFFMALIIKRIVISAGTDENFIGYL SYTPSLNILLQALTIVIAATIVSMEFDKKTIKFLLIRPVKRQKVFWSKLITVVMVSFY LYLAYYILALLFGLLFFGTSVTAESKTLLVNTLALIGSNWLEAVMMGLFGLLCSSLFR NSAVAVVVSFVVLYGASTLVQLMKLFENKWGSFLLFANTDFTQYRSGETALFSGMTPL FSIGILIIHAIFFIVVGWWCFCKRDVRV*" /label="ydbK CDS" gene 485421..486161 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /label="ydbK gene" misc_feature 486220..486239 /Source="Nicolas_upshift_promotors" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 486225 /Source="Nicolas_upshifts" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 486256..486591 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928292; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative glyco-prenyl flippase subunit" /protein_id="NP_388332.1" /db_xref="EnsemblGenomes-Gn:BSU04510" /db_xref="EnsemblGenomes-Tr:CAB12258" /db_xref="GOA:P96607" /db_xref="SubtiList:BG12079" /db_xref="UniProtKB/Swiss-Prot:P96607" /translation="MRNFITALPIVLLLGFSFVSFMFQFEHLVYFRLALGLFSLVGLY MIYKMKTGIRYFIIYLYASWIVLAAVTAFEEPIFSSFFFGGLVMTMGYLTYMLIYLGM KQDRDANPV*" /label="ydbL CDS" gene 486256..486591 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /label="ydbL gene" downshifts 486566 /Source="Nicolas_upshifts" /id="D214" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="5.33473" /MaxDrop="5.39081" /score="25.8152101" /energy="-18.4" /TU="U352,U353" /idTUdmin="U352" /TUdmin="-1177" /isTUend="FALSE" /label="downshifts" S_feature 486611..486680 /Source="Nicolas_S_feature" /locus_tag="new_505044_505113" /HighExp="ferm, nit, S2, S0, Gly, M0t45, M0t90, Lbstat, M/G, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.99, 0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S152" promotor_-35 486646..486653 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 486667..486686 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 486681 /Source="Nicolas_upshifts" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 486719..487864 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA dehydrogenase" /protein_id="NP_388333.1" /db_xref="EnsemblGenomes-Gn:BSU04520" /db_xref="EnsemblGenomes-Tr:CAB12259" /db_xref="GOA:P96608" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013107" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG12080" /db_xref="UniProtKB/Swiss-Prot:P96608" /translation="MSLFIQNDQQRQWMEKIGRIADEFQQTAAEDDEQGRFPAEKIQK LRDAGYTALTLPASHGGGGISVYDMLLFQERLARGDAPTALSIGWHLSVIGELGEGNS WDEDVFAFVAKEVQNGAVINRAATEAKTGSPTRGGRPGTHAVKKDGKWAVNGRKTFTT MSQALDYFLVTAWIEDKQTTGVFLIHKDDPGLSIEETWDMMAMRATGSHDLVLNEVML DENKLVELLQGPRGAKPNGWLLHIPAIYLGVAQAARDYAVQFASEYSPNSLNGPIKNV PAVQQRTGEMELELLNARHFLFHIAQLYDDPVRRPHLTSELGAAKHIVTNAALSVVDK AMRIVGAKSLERTNPLQRYYRDVRAGLHNPPMDDAVIHKLAAEAFES*" /label="ydbM CDS" gene 486719..487864 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /label="ydbM gene" downshifts 487846 /Source="Nicolas_upshifts" /id="D215" /incds=0 /nref=13 /ntot=123 /MaxReadThrough="2.90782" /MaxDrop="4.20573" /score="9.48525091" /energy="-7" /TU="NA" /idTUdmin="U353" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(487889..488068) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /experiment="publication(s) with functional evidences, PMID:12354229, 16428414, 18697947, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16428414, 18697947, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="NP_388334.1" /db_xref="EnsemblGenomes-Gn:BSU04530" /db_xref="EnsemblGenomes-Tr:CAB12260" /db_xref="GOA:P96609" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG12081" /db_xref="UniProtKB/Swiss-Prot:P96609" /translation="MNTNMSGGRRSMPKRKVKTYQQLIQENKEAIMGNPKLMNVIYDR IDRKHQKNLQEQNNT*" /label="fbpB CDS" gene complement(487889..488068) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /label="fbpB gene" downshifts complement(487907) /Source="Nicolas_upshifts" /id="D216" /incds=0 /nref=158 /ntot=207 /MaxReadThrough="2.35872" /MaxDrop="6.38199" /score="26.3317207" /energy="-7" /TU="NA" /idTUdmin="U355" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(488022..488186) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513944.1" /db_xref="EnsemblGenomes-Gn:BSU04536" /db_xref="EnsemblGenomes-Tr:CCQ48594" /db_xref="InterPro:IPR025072" /db_xref="UniProtKB/TrEMBL:L8ECQ9" /translation="MTPQSAEIRKKQLIHLLIQNGIYKKSKRHLYELSLTELESEYKH VRRAPEHAEA*" /label="fbpA CDS" gene complement(488022..488186) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /label="fbpA gene" S_feature complement(488069..488237) /Source="Nicolas_S_feature" /locus_tag="new_506502_506670_c" /HighExp="B60, nit, B36, Lbexp, GM 15, GM 10, dia0, S2, GM 25, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99141199999999996" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S153" promotor_-10 complement(488229..488248) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(488239) /Source="Nicolas_upshifts" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(488263..488270) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 488378..488383 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 488399..488417 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 488403 /Source="Nicolas_upshifts" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="upshifts" CDS 488433..489305 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cation efflux system" /protein_id="NP_388335.1" /db_xref="EnsemblGenomes-Gn:BSU04540" /db_xref="EnsemblGenomes-Tr:CAB12261" /db_xref="GOA:P96610" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12082" /db_xref="UniProtKB/Swiss-Prot:P96610" /translation="MERTENLKKGEKGALLNIFAYVILAVVKLVIGILYHSEALRADG LNNGTDIVASVAVLIGLRISQRPADSDHPYGHYRAETISSLVASFIMMAVGIEVLIGG GKAIAGGTTETPNLIAAWTALGSAVFMYGIYLYNKRLAASIKSSALMAAAKDSRSDAF VSAGAFIGVFSSQLKLPWVDPVTAFIIGIIICKTAWDIFKDASHSLTDGFHLKDLEPY KQTVGRIENVHRLKDVKARYLGSTVHIEMVITVDPKLTVEEGHGVADEVEDKIKHEHD VTHVHVHVEPDDIK*" /label="ydbO CDS" gene 488433..489305 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /label="ydbO gene" promotor_-35 488669..488678 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 488691..488706 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 488694 /Source="Nicolas_upshifts" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(489250..489319) /Source="Nicolas_S_feature" /locus_tag="new_507683_507752_c" /HighExp="LPhT, dia15, dia5, Diami, Etha, Lbtran, LBGtran, LBGstat, Mt0, M0t45" /AntisenseName="ydbO" /AntisenseCor="0.18463882527998399" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S154" downshifts complement(489293) /Source="Nicolas_upshifts" /id="D217" /incds=0 /nref=145 /ntot=242 /MaxReadThrough="3.07579" /MaxDrop="6.00116" /score="9.69023537" /energy="-12.3" /TU="U359" /idTUdmin="U359" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 489306..489655 /Source="Nicolas_S_feature" /locus_tag="new_507739_508088" /HighExp="Salt, Paraq, G135, ferm, Oxctl, T-0.40H, G150, Lbexp, T3.0H, T2.30H" /AntisenseName="ydbP" /AntisenseCor="-0.27800721625230801" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S155" CDS complement(489320..489640) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388336.1" /db_xref="EnsemblGenomes-Gn:BSU04550" /db_xref="EnsemblGenomes-Tr:CAB12262" /db_xref="GOA:P96611" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12083" /db_xref="UniProtKB/Swiss-Prot:P96611" /translation="MKKITTNEQFNELIQSDKEIIVKFYADWCPDCTRMNMFIGDILE EYNQNDWYELNKDELPDLAEKYQVMGIPSLLIFKNGEKTAHLHSANAKTPEEVTEFLS EHIS*" /label="ydbP CDS" gene complement(489320..489640) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /label="ydbP gene" promotor_-35 489636..489640 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 489649..489663 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 489657..489814 /Source="Nicolas_S_feature" /locus_tag="new_508090_508247" /HighExp="Lbexp, dia0, LBGexp, H2O2, Paraq, Oxctl, G180, Salt, M0t45, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigWXY" /TUshortPSig="0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S156" upshifts 489657 /Source="Nicolas_upshifts" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(489661..489680) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(489676) /Source="Nicolas_upshifts" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(489694..489701) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-35" CDS 489815..490879 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /EC_number="6.3.2.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8662022, 12682299, 22407814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine ligase A" /protein_id="NP_388337.1" /db_xref="EnsemblGenomes-Gn:BSU04560" /db_xref="EnsemblGenomes-Tr:CAB12263" /db_xref="GOA:P96612" /db_xref="InterPro:IPR000291" /db_xref="InterPro:IPR005905" /db_xref="InterPro:IPR011095" /db_xref="InterPro:IPR011127" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11932" /db_xref="UniProtKB/Swiss-Prot:P96612" /translation="MYGGKSAEHNVSLQTALAVIKALNTEKFDIHPIYITEKGEWVRG ARLTEPVSNVKMLQFEQGGSAFSPAALNQEMFPQEASQQNEAIDVVFPLLHGPNGEDG TIQGMLELLNIPYVGNGVLASSAGMDKVVMKHLFAQVGLAQAKYAAFLKKDWTRSPKE SCEEVEQELGYPCFVKPANLGSSVGISKCRNREELQKAFELAFQYDRKVVVEEGINGR EIEIGVLGNDDPKCSVVGEIAPKTDFYDYKAKYEDGDTDLMIPAIVTDEEYATISDMA IKAFKAIDGSGLVRADFFLTADGEVLINEVNTMPGFTPFSMFPLLWKEAGVEYADLIE QLVELAKERHAEKQLIKHTF*" /label="ddlA CDS" gene 489815..490879 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /label="ddlA gene" downshifts 490867 /Source="Nicolas_upshifts" /id="D218" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="5.68418" /MaxDrop="2.53103" /score="3.92144467" /energy="-9.6" /TU="U357,U358" /idTUdmin="U356" /TUdmin=2310 /isTUend="FALSE" /label="downshifts" CDS 490951..492324 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /EC_number="6.3.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-D-alanine ligase" /protein_id="NP_388338.1" /db_xref="EnsemblGenomes-Gn:BSU04570" /db_xref="EnsemblGenomes-Tr:CAB12264" /db_xref="GOA:P96613" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005863" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG12084" /db_xref="UniProtKB/Swiss-Prot:P96613" /translation="MIKRTVKNIAEMVKGTLANPQYEQTVIHGVATDTRKLEQHQLFI PLKGERFDGHSFVEQAFEAGVAAVLWDRSVPNPPENHAVILVDDTLTALQQLAKAYLQ ELGTRVIGVTGSNGKTTTKDMIHAVLGTQYRVHKTGGNFNNHIGLPLTVLAMPENTEI AVLEMGMSAKGEIDLLSRLANPDAAVITNIGESHMQDLGSREGIAEAKLEIINGLKED GVLIYIGDEPLLQNAYSCQTKTYGTGTHNDYQLQDVSQSEEGTHFTIKGIENTFFIPI LGKHNVMNAMAAIAAGAYFGIAPEDAAKGLSGLKVTGMRLELIKTDSGLSIINDAYNA SPTSMKAAIQLTESLEGYGKKMLVLGDMLELGDLEETFHKECGAVISPDKIDRVFTYG KLGAFIAEGALKHFEKDRVSHYTEKKDLLQAVKENASKGDLILFKASRGMKLEEIVKD LIESPLS*" /label="murF CDS" gene 490951..492324 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /label="murF gene" promotor_-35 492355..492361 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 492375..492386 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 492385 /Source="Nicolas_upshifts" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 492428..492447 /Source="Nicolas_upshift_promotors" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 492429..492603 /Source="Nicolas_S_feature" /locus_tag="new_510862_511036" /HighExp="Cold, ferm, nit, G135, S5, LBGexp, G150, S8, S7, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.76694499999999999" /TUshortSig="SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S157" upshifts 492429 /Source="Nicolas_upshifts" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 492571..492578 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 492593..492612 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 492605..492672 /Source="Nicolas_S_feature" /locus_tag="new_511038_511105" /HighExp="Cold, G150, T-3.40H, HPh, Salt, LPh, G180, G135, Oxctl, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S158" upshifts 492605 /Source="Nicolas_upshifts" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="upshifts" CDS 492724..494208 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16352840, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352840, 27965645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_388339.2" /db_xref="EnsemblGenomes-Gn:BSU04580" /db_xref="EnsemblGenomes-Tr:CAB12265" /db_xref="GOA:P96614" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030880" /db_xref="SubtiList:BG12085" /db_xref="UniProtKB/Swiss-Prot:P96614" /translation="MTITFQDFNLSSDLMKAINRMGFEEATPIQAQTIPLGLSNKDVI GQAQTGTGKTAAFGIPLVEKINPESPNIQAIVIAPTRELAIQVSEELYKIGQDKRAKV LPIYGGQDIGRQIRALKKNPNIIVGTPGRLLDHINRRTIRLNNVNTVVMDEADEMLNM GFIDDIESILSNVPSEHQTLLFSATMPAPIKRIAERFMTEPEHVKVKAKEMTVSNIQQ FYLEVQERKKFDTLTRLLDIQSPELAIVFGRTKRRVDELAEALNLRGYAAEGIHGDLT QAKRMVALRKFKEGAIEVLVATDVAARGLDISGVTHVYNFDVPQDPESYVHRIGRTGR AGKTGMAMTFITPREKSMLRAIEQTTKRKMDRMKEPTLDEALEGQQQVTVERLRTTIS ENNLNFYMTAAAELLEDHDAVTVVAAAIKMATKEPDDTPVRLTDEAPMVSKRYKNQRS SKRRDGQGGGYRGGKGKSNNRSSYDKKRSNDRRSSGDRRQKKSY*" /label="cshA CDS" gene 492724..494208 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /label="cshA gene" downshifts 494201 /Source="Nicolas_upshifts" /id="D219" /incds=0 /nref=309 /ntot=313 /MaxReadThrough="1.91428" /MaxDrop="8.13079" /score="26.104757" /energy="-13.1" /TU="NA" /idTUdmin="U358" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" S_feature 494321..494380 /Source="Nicolas_S_feature" /locus_tag="new_512754_512813" /HighExp="Etha, LBGexp, G180, Cold, Lbtran, dia0, G150, BMM, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S159" promotor_-35 494321..494330 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 494323 /Source="Nicolas_upshifts" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 494342..494357 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 494381..494860 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388340.1" /db_xref="EnsemblGenomes-Gn:BSU04590" /db_xref="EnsemblGenomes-Tr:CAB12266" /db_xref="GOA:P96615" /db_xref="InterPro:IPR005182" /db_xref="SubtiList:BG12086" /db_xref="UniProtKB/Swiss-Prot:P96615" /translation="MREQPKNQISPDGLKVWRLQEIIISAVCLLIVIAVAVLSYYFHW PYWISGVLGAVWLLGSIVTVFIIPKVRHKVWRYEVHEHEIDIQSGIFVVTRVIVPMVR VQHVDTSQGPLLKKYNLATVKISTAATVHSIPALEMEEADRLRDSISRLARVTDDDV* " /label="ydbS CDS" gene 494381..494860 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /label="ydbS gene" CDS 494850..496331 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388341.1" /db_xref="EnsemblGenomes-Gn:BSU04600" /db_xref="EnsemblGenomes-Tr:CAB12267" /db_xref="GOA:P96616" /db_xref="InterPro:IPR005182" /db_xref="InterPro:IPR014529" /db_xref="SubtiList:BG12087" /db_xref="UniProtKB/Swiss-Prot:P96616" /translation="MMSEPKRLHPVAVILNLCHTIIQTIKNIILPFFFVYIVNSNHTV RFYGAIALGVLFIWLVAASIIKWRRFTYRIEDDEFRIEEGLFVTKKRYISIDRIQTMN TSAGLVQQIFKLVKLQIETAGGGKEAEAVLSAISVEEAERIKEAVFKKKAQRRENELD EERLEAEEELDPSVEVQEHYRMNAKELLMAASTSGGIGVIISAVFALISQLDEVLPMD WLFDKFSFLQHASIGIYAVLIFIGLFIAWIFSIAGMMFRYANFQIIKKEQELVISRGI IEKHQVTIPLRKIQAIKIKENIIRQLFGFVTVSIVSAGGGDREKEEGALTILFPMIHK KKLPHMLRTFTPEYTLEENCRRLPRRALKRYLFRSVIFSLFLIIPLCIFFQPWGYLSV ILLPIELLFGYLAYKEAAWTINGDRLQLTSRFIGRTTAIVLKKRMQVCKFSQSYFQKK GRLYTISTSVKSSSHMEELTVRDVGEEDAAFILKWYSYEKADG*" /label="ydbT CDS" gene 494850..496331 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /label="ydbT gene" downshifts 496301 /Source="Nicolas_upshifts" /id="D220" /incds=0 /nref=6 /ntot=162 /MaxReadThrough="4.90913" /MaxDrop="3.0931" /score="48.2239319" /energy="-17.1" /TU="U363" /idTUdmin="U364" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" S_feature 496346..496673 /Source="Nicolas_S_feature" /locus_tag="new_514779_515106" /HighExp="Salt, T0.30H, G135, T1.0H, T1.30H, G150, G180, Oxctl, T-0.40H, aero" /AntisenseName="ydcA" /AntisenseCor="-0.25636523135066602" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S160" downshifts complement(496355) /Source="Nicolas_upshifts" /id="D221" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="0.258529999999999" /MaxDrop="3.15455" /score="-3.74867023" /energy="-8.8" /TU="NA" /idTUdmin="U365" /TUdmin=220 /isTUend="FALSE" /label="downshifts" CDS complement(496583..497182) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /EC_number="3.4.21.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15616571, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative rhomboid protease" /protein_id="NP_388342.1" /db_xref="EnsemblGenomes-Gn:BSU04610" /db_xref="EnsemblGenomes-Tr:CAB12268" /db_xref="GOA:P96617" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG12088" /db_xref="UniProtKB/Swiss-Prot:P96617" /translation="MFIRTENFQTFIRLYPVVTFILALQAVLWLFFSLPAHSVVLWRD TVTGYNLGVANGEWWRLITPILLHAGFTHLLFNSMSIFLFAPALERMLGKARFLLVYA GSGIIGNIGTYVTEPLDYVHVGASGAIFGLFGVYLFMVLFRNELIGQEHSKMIITLLA FAVLMSFINSNINMMAHLFGLCGGFLLSFLCVQKKERRY*" /label="ydcA CDS" gene complement(496583..497182) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /label="ydcA gene" promotor_-35 496643..496648 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 496661..496680 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 496675..497276 /Source="Nicolas_S_feature" /locus_tag="new_515108_515709" /HighExp="Salt, G135, G150, T0.30H, G180, T1.0H, T1.30H, H2O2, Paraq, Oxctl" /AntisenseName="ydcA" /AntisenseCor="-0.11975373672841701" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S161" upshifts 496675 /Source="Nicolas_upshifts" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(497206..497225) /Source="Nicolas_upshift_promotors" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(497217) /Source="Nicolas_upshifts" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="upshifts" CDS 497277..497642 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /EC_number="2.7.8.7" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11489886, 11525165, 11867633, 12682299, 12926246, 15955059, 16597923; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="holo-acyl carrier protein synthase (phosphopantetheinyl transferase)" /protein_id="NP_388343.1" /db_xref="EnsemblGenomes-Gn:BSU04620" /db_xref="EnsemblGenomes-Tr:CAB12269" /db_xref="GOA:P96618" /db_xref="InterPro:IPR002582" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1F7L" /db_xref="PDB:1F7T" /db_xref="PDB:1F80" /db_xref="SubtiList:BG12089" /db_xref="UniProtKB/Swiss-Prot:P96618" /translation="MIYGIGLDITELKRIASMAGRQKRFAERILTRSELDQYYELSEK RKNEFLAGRFAAKEAFSKAFGTGIGRQLSFQDIEIRKDQNGKPYIICTKLSQAAVHVS ITHTKEYAAAQVVIERLSS*" /label="acpS CDS" gene 497277..497642 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /label="acpS gene" promotor_-35 497645..497650 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-35" S_feature 497666..497807 /Source="Nicolas_S_feature" /locus_tag="new_516099_516240" /HighExp="S3, S4, BT, LoTm, S5, T5.0H, M9-stat, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S162" promotor_-10 497666..497684 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-10" upshifts 497666 /Source="Nicolas_upshifts" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="upshifts" CDS 497808..498824 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388344.2" /db_xref="EnsemblGenomes-Gn:BSU04630" /db_xref="EnsemblGenomes-Tr:CAB12270" /db_xref="GOA:P96619" /db_xref="InterPro:IPR029046" /db_xref="SubtiList:BG12090" /db_xref="UniProtKB/Swiss-Prot:P96619" /translation="MKKVRKSFVLLLTGLLAVLILSACGQKTQQDIVAGLDEKAKEYT SYKAKAKMTIETGSEPQVYNVEIWHKKPSLYRVYLENPKKDQNQVILRNENGVFVLTP SLNKSFRFQSDWPNNSSQVYLFESLVKDVQNDSDAVFTAKEKKYVFETKTNYQHNKML PTQEITFNKKDMSPSSVKVMDTDRKVMVKVEFSSFEFNKQFDKESFDEKKNMTLSQMD VATSAKPSDTFAVKTPLELPLGVKLLEEKDISTEDGKRIIMTYGGEKSFTLIQEKAQI AKASSSVTLNGEPVNLGYTIGALSDASLSWTYDGVDYLLSSKDLSKEEMVTVAKSMQG QSSK*" /label="ydcC CDS" gene 497808..498824 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /label="ydcC gene" downshifts 498809 /Source="Nicolas_upshifts" /id="D222" /incds=0 /nref=193 /ntot=256 /MaxReadThrough="3.39815" /MaxDrop="6.13946" /score="22.0391647" /energy="-9.5" /TU="U366" /idTUdmin="U363" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 498869..498876 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 498890..498909 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 498897 /Source="Nicolas_upshifts" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 498939..500108 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /EC_number="5.1.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2835089, 12682299, 15043879, 18399999, 25227915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine racemase" /protein_id="NP_388345.1" /db_xref="EnsemblGenomes-Gn:BSU04640" /db_xref="EnsemblGenomes-Tr:CAB12271" /db_xref="GOA:P10725" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10950" /db_xref="UniProtKB/Swiss-Prot:P10725" /translation="MSTKPFYRDTWAEIDLSAIKENVSNMKKHIGEHVHLMAVVKANA YGHGDAETAKAALDAGASCLAVAILDEAISLRKKGLKAPILVLGAVPPEYVAIAAEYD VTLTGYSVEWLQEAARHTKKGSLHFHLKVDTGMNRLGVKTEEEVQNVMAILDRNPRLK CKGVFTHFATADEKERGYFLMQFERFKELIAPLPLKNLMVHCANSAAGLRLKKGFFNA VRFGIGMYGLRPSADMSDEIPFQLRPAFTLHSTLSHVKLIRKGESVSYGAEYTAEKDT WIGTVPVGYADGWLRKLKGTDILVKGKRLKIAGRICMDQFMVELDQEYPPGTKVTLIG RQGDEYISMDEIAGRLETINYEVACTISSRVPRMFLENGSIMEVRNPLLQVNISN*" /label="alrA CDS" gene 498939..500108 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /label="alrA gene" promotor_-35 500037..500042 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500057..500075 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500063 /Source="Nicolas_upshifts" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 500138..500141 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500157..500176 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500158 /Source="Nicolas_upshifts" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 500224..500505 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antitoxin EndoAI" /protein_id="NP_388346.1" /db_xref="EnsemblGenomes-Gn:BSU04650" /db_xref="EnsemblGenomes-Tr:CAB12272" /db_xref="GOA:P96621" /db_xref="InterPro:IPR002145" /db_xref="InterPro:IPR010985" /db_xref="InterPro:IPR013321" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12091" /db_xref="UniProtKB/Swiss-Prot:P96621" /translation="MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAY VSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAECEAETTVERLVSGG*" /label="ndoAI CDS" gene 500224..500505 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /label="ndoAI gene" CDS 500510..500860 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 21897862, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 21897862, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease toxin" /protein_id="NP_388347.1" /db_xref="EnsemblGenomes-Gn:BSU04660" /db_xref="EnsemblGenomes-Tr:CAB12273" /db_xref="GOA:P96622" /db_xref="InterPro:IPR003477" /db_xref="InterPro:IPR011067" /db_xref="PDB:1NE8" /db_xref="PDB:4MDX" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12092" /db_xref="UniProtKB/Swiss-Prot:P96622" /translation="MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIV AAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQIRTIDKQRLTDKITHLDDEMMDK VDEALQISLALIDF*" /label="ndoA CDS" gene 500510..500860 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /label="ndoA gene" S_feature complement(500650..501126) /Source="Nicolas_S_feature" /locus_tag="new_519083_519559_c" /HighExp="Etha, Gly, Sw, S8, C30, S6, LBGstat, T0.30H, S7, Salt" /AntisenseName="ndoA" /AntisenseCor="-0.36117231948253697" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigK" /TUshortPSig="1, 1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S163" downshifts complement(500693) /Source="Nicolas_upshifts" /id="D223" /incds=1 /nref=6 /ntot=171 /MaxReadThrough="3.51096" /MaxDrop="3.79912" /score="-8.86444162" /energy="-10.2" /TU="U372" /idTUdmin="U371" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" downshifts 500840 /Source="Nicolas_upshifts" /id="D224" /incds=0 /nref=143 /ntot=254 /MaxReadThrough="5.57908" /MaxDrop="5.74865" /score="29.7721113" /energy="-8.9" /TU="U367,U368,U369" /idTUdmin="U366" /TUdmin=799 /isTUend="FALSE" /label="downshifts" promotor_-35 500894..500901 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500915..500934 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500923 /Source="Nicolas_upshifts" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 500975..501799 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome); positive regulation of sigma(B) activity in response to salt and heat stress" /protein_id="NP_388348.1" /db_xref="EnsemblGenomes-Gn:BSU04670" /db_xref="EnsemblGenomes-Tr:CAB12274" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR014792" /db_xref="InterPro:IPR036513" /db_xref="PDB:2BNL" /db_xref="SubtiList:BG11090" /db_xref="UniProtKB/Swiss-Prot:P42409" /translation="MMSNQTVYQFIAENQNELLQLWTDTLKELSEQESYQLTDQVYEN ISKEYIDILLLSVKDENAAESQISELALRAVQIGLSMKFLATALAEFWKRLYTKMNDK RLPDQESTELIWQIDRFFSPINTEIFNQYSISWEKTVSLQKIALQELSAPLIPVFENI TVMPLVGTIDTERAKRIMENLLNGVVKHRSQVVLIDITGVPVVDTMVAHHIIQASEAV RLVGAKCLLAGIRPEIAQTIVNLGIDLSQVITKNTLQKGIQTALEMTDRKIVSLGE*" /label="rsbRA CDS" gene 500975..501799 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /label="rsbRA gene" promotor_-10 complement(501109..501127) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(501126) /Source="Nicolas_upshifts" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(501128..501727) /Source="Nicolas_S_feature" /locus_tag="new_519561_520160_c" /HighExp="Etha, Sw, Gly, S6, S8, S7, B60, Salt, BT, M9-stat" /AntisenseName="rsbRA" /AntisenseCor="-0.53924606340364201" /AntisenseRegPval="-21" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S164" promotor_-35 complement(501141..501148) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(501716..501734) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(501727) /Source="Nicolas_upshifts" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(501729..502317) /Source="Nicolas_S_feature" /locus_tag="new_520162_520750_c" /HighExp="S6, S8, S7, BT, C30, S5, G135, C90, Gly, Fru" /AntisenseName="rsbS" /AntisenseCor="-0.57706416777859804" /AntisenseRegPval="-24.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S165" promotor_-35 complement(501748..501754) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 501804..502169 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 23320651, 28271471; Product type f : factor" /codon_start=1 /transl_table=11 /product="antagonist of RsbT" /protein_id="NP_388349.1" /db_xref="EnsemblGenomes-Gn:BSU04680" /db_xref="EnsemblGenomes-Tr:CAB12275" /db_xref="GOA:P42410" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11091" /db_xref="UniProtKB/Swiss-Prot:P42410" /translation="MRHPKIPILKLYNCLLVSIQWELDDQTALTFQEDLLNKIYETGA NGVVIDLTSVDMIDSFIAKVLGDVITMSKLMGAKVVLTGIQPAVAVTLIELGIALEEI ETALDLEQGLETLKRELGE*" /label="rsbS CDS" gene 501804..502169 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /label="rsbS gene" CDS 502173..502574 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine-threonine kinase; controlsthe activity of the anxiosome (stressosome)" /protein_id="NP_388350.1" /db_xref="EnsemblGenomes-Gn:BSU04690" /db_xref="EnsemblGenomes-Tr:CAB12276" /db_xref="GOA:P42411" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11092" /db_xref="UniProtKB/Swiss-Prot:P42411" /translation="MNDQSCVRIMTEWDIVAARQLGRNVAKELGFGTVDQARITTAIS ELARNIYLYAGKGQIGIEQVADRGKKGLKIIAEDQGPGIPDIRKVMEDGFSTSGGLGA GLPGVKRLMDEFSLNSVAGEGTEIQAIKWLR*" /label="rsbT CDS" gene 502173..502574 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /label="rsbT gene" promotor_-10 complement(502315..502334) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(502332) /Source="Nicolas_upshifts" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(502348..502357) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 502586..503593 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 17303566, 21979936, 28461450" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 17303566, 21979936, 28461450; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine phosphatase; controls the activity of the anxiosome (stressosome)" /protein_id="NP_388351.1" /db_xref="EnsemblGenomes-Gn:BSU04700" /db_xref="EnsemblGenomes-Tr:CAB12277" /db_xref="GOA:P40399" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014787" /db_xref="InterPro:IPR017944" /db_xref="InterPro:IPR036457" /db_xref="PDB:1W53" /db_xref="PDB:2J6Y" /db_xref="PDB:2J6Z" /db_xref="PDB:2J70" /db_xref="SubtiList:BG11057" /db_xref="UniProtKB/Swiss-Prot:P40399" /translation="MDFREVIEQRYHQLLSRYIAELTETSLYQAQKFSRKTIEHQIPP EEIISIHRKVLKELYPSLPEDVFHSLDFLIEVMIGYGMAYQEHQTLRGIQQEIKSEIE IAANVQQTLLGTKVPQEEALDIGAISVPAKQMSGDYYHFVKDKESINIAIADVIGKGI PAALCMSMIKYAMDSLPETGIHPSQVLKNLNRVVEQNVDASMFITMFYANYNMDKHQF TYASAGHEPGFYYSQKDNTFYDLEAKGLVLGISQDYDYKQFDQHLEKGDMIVLFSDGV TECRTENGFLERPDLQKLIEEHMCSSAQEMVKNIYDSLLKLQDFQLHDDFTLIVLRRK V*" /label="rsbU CDS" gene 502586..503593 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /label="rsbU gene" promotor_-35 503587..503593 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 503608..503626 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 503614 /Source="Nicolas_upshifts" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 503655..503984 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677; Product type f: factor" /codon_start=1 /transl_table=11 /product="anti-anti-sigma factor (antagonist of RsbW)" /protein_id="NP_388352.1" /db_xref="EnsemblGenomes-Gn:BSU04710" /db_xref="EnsemblGenomes-Tr:CAB12278" /db_xref="GOA:P17903" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR003658" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG10733" /db_xref="UniProtKB/Swiss-Prot:P17903" /translation="MNINVDVKQNENDIQVNIAGEIDVYSAPVLREKLVPLAEQGADL RICLKDVSYMDSTGLGVFVGTFKMVKKQGGSLKLENLSERLIRLFDITGLKDIIDISA KSEGGVQ*" /label="rsbV CDS" gene 503655..503984 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /label="rsbV gene" CDS 503981..504463 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 21979936, 27977677; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine kinase and anti-sigma factor (inhibitory sigma-B binding protein)" /protein_id="NP_388353.1" /db_xref="EnsemblGenomes-Gn:BSU04720" /db_xref="EnsemblGenomes-Tr:CAB12279" /db_xref="GOA:P17904" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010193" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10734" /db_xref="UniProtKB/Swiss-Prot:P17904" /translation="MKNNADYIEMKVPAQPEYVGIIRLTLSGVASRMGYTYDEIEDLK IAVSEACTNAVQHAYKEDKNGEVSIRFGVFEDRLEVIVADEGDSFDFDQKQQDLGPYT PSHTVDQLSEGGLGLYLMETLMDEVRVQNHSGVTVAMTKYLNGERVDHDTTIKNYETN *" /label="rsbW CDS" gene 503981..504463 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /label="rsbW gene" CDS 504429..505217 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-37 factor (sigma(B))" /protein_id="NP_388354.2" /db_xref="EnsemblGenomes-Gn:BSU04730" /db_xref="EnsemblGenomes-Tr:CAB12280" /db_xref="GOA:P06574" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014288" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10735" /db_xref="UniProtKB/Swiss-Prot:P06574" /translation="MTQPSKTTKLTKDEVDRLISDYQTKQDEQAQETLVRVYTNLVDM LAKKYSKGKSFHEDLRQVGMIGLLGAIKRYDPVVGKSFEAFAIPTIIGEIKRFLRDKT WSVHVPRRIKELGPRIKMAVDQLTTETQRSPKVEEIAEFLDVSEEEVLETMEMGKSYQ ALSVDHSIEADSDGSTVTILDIVGSQEDGYERVNQQLMLQSVLHVLSDREKQIIDLTY IQNKSQKETGDILGISQMHVSRLQRKAVKKLREALIEDPSMELM*" /label="sigB CDS" gene 504429..505217 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /label="sigB gene" CDS 505217..505816 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine phosphatase" /protein_id="NP_388355.1" /db_xref="EnsemblGenomes-Gn:BSU04740" /db_xref="EnsemblGenomes-Tr:CAB12281" /db_xref="GOA:P17906" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR036457" /db_xref="PDB:3W40" /db_xref="PDB:3W41" /db_xref="PDB:3W42" /db_xref="PDB:3W43" /db_xref="PDB:3W44" /db_xref="PDB:3W45" /db_xref="SubtiList:BG10736" /db_xref="UniProtKB/Swiss-Prot:P17906" /translation="MIQVEENEHIQTLVYQLNKEGKSICGDSFFMKADDKELICAVAD GLGSGSLANESSAAIKDLVENYASEDVESIIERCNQAMKNKRGATASILKINFEQRQF TYCSVGNVRFILHSPSGESFYPLPISGYLSGKPQKYKTHTATYEKGSKFIIHTDGLNV PDIRSHLKKGQSVEEISNSLKMYTTSRKDDLTYILGQLS*" /label="rsbX CDS" gene 505217..505816 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /label="rsbX gene" downshifts 505802 /Source="Nicolas_upshifts" /id="D225" /incds=0 /nref=267 /ntot=278 /MaxReadThrough="2.46753" /MaxDrop="7.92167" /score="1.26147577" /energy="-6" /TU="NA" /idTUdmin="U369" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 505860..505866 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 505881..505900 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" Polymorphism join(505889,505891) /Source="geneious" /ID="SNP_BsDelta6_524323_524323" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="A -> C" /Codon_Change /Coverage=183 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=183 /comment="BSU_04745_promoter_down_mutation" /modified_by="User" / /label="Polymorphism_Delta6" upshifts 505893 /Source="Nicolas_upshifts" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 505927..506043 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513945.1" /translation="MWNYEYTAIADVDVGKPGTVIRKQKQWINGRRVLHQIL*" /label="hypothetical protein CDS" gene 505927..506043 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /label="gene" CDS 506059..506352 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388356.1" /db_xref="EnsemblGenomes-Gn:BSU04750" /db_xref="EnsemblGenomes-Tr:CAB12282" /db_xref="SubtiList:BG12093" /db_xref="UniProtKB/Swiss-Prot:P96623" /translation="MERKEHCFCKEKQFSYGLSMWRNIGRFLSWSTCPHSNVIMEFFH VLQKQKEDLCITYGIVLEGAEAKKWGEIIGTELSKDMPTAVSRLVHLYGGVIK*" /label="ydcF CDS" gene 506059..506352 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /label="ydcF gene" promotor_-35 506320..506328 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 506340..506359 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 506349..506789 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388357.1" /db_xref="EnsemblGenomes-Gn:BSU04760" /db_xref="EnsemblGenomes-Tr:CAB12283" /db_xref="InterPro:IPR002740" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR022996" /db_xref="SubtiList:BG12094" /db_xref="UniProtKB/Swiss-Prot:P96624" /translation="MNTNYWIGVVSEQHVLKGAAGGFAQLCHGKKAPLAKMKEGDWLI YYSPRDAYPDGKLLRSFTAIGKVKSGNIYPYQMAPNFIPYRLDIDYYPCHKIGFYDIK SKLEFVQETKHLGFLFRRGHFEISKKDFLTIAQAMGVNISGMAL*" /label="ydcG CDS" gene 506349..506789 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /label="ydcG gene" upshifts 506355 /Source="Nicolas_upshifts" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(506588..509643) /Source="Nicolas_S_feature" /locus_tag="new_525021_528076_c" /HighExp="S6, S8, S7, S5, B36, S4, B60, BT, Pyr, C30" /AntisenseName="ydcI" /AntisenseCor="-0.61304426345041496" /AntisenseRegPval="-28.4" /CDS_PredictionProba="0.40759499999999999" /TUshortSig="SigK" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S166" CDS 506773..507216 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12088660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388358.1" /db_xref="EnsemblGenomes-Gn:BSU04770" /db_xref="EnsemblGenomes-Tr:CAB12284" /db_xref="GOA:P96625" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12095" /db_xref="UniProtKB/Swiss-Prot:P96625" /translation="MEWHSKFSGPNTSPGFLLWQATQSWQRKVGKALAEFDLTHVQFV LLTSCKYMIAHGETVTQKKLASFSQTNIMMVSEVVRTLEKKGFIERSKNPQDKREVLL SLTEIGGEKVTAALPIVEKIDQAFFAAAMKKENFLSGLQELLKHE*" /label="ydcH CDS" gene 506773..507216 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /label="ydcH gene" downshifts 507191 /Source="Nicolas_upshifts" /id="D226" /incds=0 /nref=11 /ntot=147 /MaxReadThrough="2.17786" /MaxDrop="3.86856" /score="21.3746204" /energy="-6.8" /TU="NA" /idTUdmin="U376" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 507247..507248 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-35" promotor_-10 507264..507283 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-10" upshifts 507264 /Source="Nicolas_upshifts" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="upshifts" CDS 507310..509469 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755871, 12910271, 15383836, 16282592; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA helicase transcriptional accessory protein" /protein_id="NP_388359.2" /db_xref="EnsemblGenomes-Gn:BSU04780" /db_xref="EnsemblGenomes-Tr:CAB12285" /db_xref="GOA:O31489" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018974" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR023319" /db_xref="InterPro:IPR023323" /db_xref="InterPro:IPR032639" /db_xref="SubtiList:BG12096" /db_xref="UniProtKB/Swiss-Prot:O31489" /translation="METSALLKQQIAKEIGLSQKHVESVIRLLEDGNTVPFIARYRKE QTGSMDEVQIQTISERWQYIQNLNQRKEEVIRLIAEQDKLTDNLKRKIEQSVKLQEVE DLYRPYKQKRKTKATVAKSKGLEPLADYILTLPQDDHLAATADQYISEEKEVFTREEA IEGAKHIIAEQISDEPTFRKWIRQETFKRGTIKSAAGKSADTDEKNVYEMYYEYEEPI AKVVPHRVLAMNRGEKEDILKVAIEPPADHIKAYLEKQIIKNRSTSVREILQETIEDS YKRLIQPAIEREIRKELSEKADEQAIHIFSENLRKLLLQPPMKGKTVLGVDPAFRTGC KLAVSDETGKVLKIDVIYPHAPVNKTKEAHEKVKKILEQYQVEMVAIGNGTASRETEQ FIVNVLRDMPRKIYYVIVNEAGASVYSASELAREEFPDLKVEERSAVSIARRLQDPLA ELVKIDPKSVGVGQYQHDVSQKRLNESLRFVVETVVNQVGVNVNTASAALLQYVAGLS KSVAGNVVKKREEIGKFSNRKELKDIPRLGAKTYEQCIGFLRVQEGTEPLDRTGIHPE SYKETKALLKKLGLSTEHIGTAELKDKINQLALSETAKELGIGEITLKDICEQLTRPE RDPRDKVPKPLLKTDVLQLEDLKEGMELQGTVRNVVDFGAFVDIGVKQDGLVHISKLS NQFVKHPLDVVSVGDIVTVWVDGVDVQKGRVSLSMVK*" /label="tex CDS" gene 507310..509469 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /label="tex gene" misc_feature 509457..509476 /Source="Nicolas_upshift_promotors" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 509479..509695 /Source="Nicolas_S_feature" /locus_tag="new_527912_528128" /HighExp="Cold, Etha, LBGstat, dia5, LPhT, T4.0H, dia15, T3.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S167" upshifts 509479 /Source="Nicolas_upshifts" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="upshifts" CDS complement(509479..509592) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /function="16.3: Control" /function="16.6: Maintain" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:22463703, 26387458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22463703, 26387458; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor allowing degradation of SpoIVA by ClpXP" /protein_id="YP_009513946.1" /translation="MPNWLKKQMQKAFLEKDNYQIKLLNQCWYFYRKKHCS*" /label="cmpA CDS" gene complement(509479..509592) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /label="cmpA gene" promotor_-10 complement(509632..509651) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(509649) /Source="Nicolas_upshifts" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(509666..509674) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-35" CDS 509696..510148 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388360.1" /db_xref="EnsemblGenomes-Gn:BSU04790" /db_xref="EnsemblGenomes-Tr:CAB12286" /db_xref="GOA:P96628" /db_xref="InterPro:IPR006640" /db_xref="InterPro:IPR023524" /db_xref="InterPro:IPR035240" /db_xref="SubtiList:BG12098" /db_xref="UniProtKB/Swiss-Prot:P96628" /translation="MDNKELQKLTEDISETYFKKPFRHQALFNDRLKTTGGRYLLTSH NIELNRKYLIEHGREELIGIIKHELCHYHLHLEGKGYKHRDRDFRMLLQQVNAPRFCT PLKKKAENKKTYMYICTTCGQQYIKKRAMNPDRYRCGKCRGKIKRIFS*" /label="ydcK CDS" gene 509696..510148 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /label="ydcK gene" promotor_-35 510154..510160 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 510175..510194 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 510183..510270 /Source="Nicolas_S_feature" /locus_tag="new_528616_528703" /HighExp="C30, LBGstat, Cold, UNK1, GM 25, GM 120, GM 15, Heat, T-3.40H, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S168" upshifts 510183 /Source="Nicolas_upshifts" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(510215) /Source="Nicolas_upshifts" /id="D227" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="2.50342" /MaxDrop="3.97305" /score="8.78044068" /energy="-9.2" /TU="NA" /idTUdmin="U381" /TUdmin=704 /isTUend="FALSE" /label="downshifts" tRNA 510271..510345 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Asn tRNA" gene 510271..510345 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /label="trnS-Asn gene" tRNA 510350..510440 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Ser tRNA" gene 510350..510440 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /label="trnS-Ser gene" tRNA 510470..510541 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Glu tRNA" gene 510470..510541 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /label="trnS-Glu gene" tRNA 510553..510627 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Gln tRNA" gene 510553..510627 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /label="trnS-Gln gene" tRNA 510654..510729 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Lys tRNA" gene 510654..510729 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /label="trnS-Lys gene" tRNA 510741..510822 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Leu1 tRNA" gene 510741..510822 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /label="trnS-Leu1 gene" downshifts 510887 /Source="Nicolas_upshifts" /id="D228" /incds=0 /nref=3 /ntot=136 /MaxReadThrough="6.94232" /MaxDrop="3.5424" /score="34.987622" /energy="-13.7" /TU="U380" /idTUdmin="U378" /TUdmin=0 /isTUend="TRUE" /label="downshifts" tRNA 510903..>510988 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu (GAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Leu2 tRNA" gene 510903..>510988 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /modified_by="User" /label="trnS-Leu2 gene" SCAR 510988..510989 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="Delta6_2" S_feature complement(<510989..511295) /Source="Nicolas_S_feature" /locus_tag="new_549923_550239_c" /HighExp="Diami, dia15, dia5, HPh, Etha, H2O2, Cold, LPh, C90, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /modified_by="User" /label="S175" downshifts 511008 /Source="Nicolas_upshifts" /id="D238" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="0.144629999999999" /MaxDrop="3.58923" /score="4.45688042" /energy="-12.2" /TU="NA" /idTUdmin="U389" /TUdmin=84 /isTUend="FALSE" /label="downshifts" downshifts complement(511040) /Source="Nicolas_upshifts" /id="D239" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.31925" /MaxDrop="3.67068" /score="-2.66780619" /energy="-18.7" /TU="NA" /idTUdmin="U391" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(511296..512315) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /EC_number="1.14.14.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_388385.1" /db_xref="EnsemblGenomes-Gn:BSU05040" /db_xref="EnsemblGenomes-Tr:CAB12311" /db_xref="GOA:P96651" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12121" /db_xref="UniProtKB/Swiss-Prot:P96651" /translation="MKKFDISVLSVAPLRQGETMKQGIDSAVSLAKAVDNMGYKRIWF AEHHNHDAYASAATVSIVQHILANTKDIRVGSGGIMLPNHSPLIVAEQFGTLETLYPN RVDLALGRAPGTDQKTADVIRRSNHNGVFFFEREVNDILRFVGDKSVQGEVRAYPGIG THVPVFVLGSSTDSAEIAAKLGLPYAFGAQFSPHSMEEALSIYRENFQPSSYLQEPYV IACINVIAAESIDEASFISASHLQVYIDIYTNNLSKLIPPTENFLESLSQFELEILHS RLGYTIMGDRETIRRELIDFQQMYHADELIVLSNIYELSKEIQSYEILKQVVDELFKK RMEQL*" /label="yddN CDS" gene complement(511296..512315) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /label="yddN gene" promotor_-10 complement(511991..512010) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(512004) /Source="Nicolas_upshifts" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(512025..512032) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 512104..512108 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 512125..512144 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 512129 /Source="Nicolas_upshifts" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="upshifts" S_feature 512130..512574 /Source="Nicolas_S_feature" /locus_tag="new_551074_551518" /HighExp="dia15, dia5, H2O2, G180, G135, Paraq, HPh, LBGexp, Lbexp, G150" /AntisenseName="yddN" /AntisenseCor="0.70327972625798696" /AntisenseRegPval="-40.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S176" CDS 512575..512985 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388386.1" /db_xref="EnsemblGenomes-Gn:BSU05050" /db_xref="EnsemblGenomes-Tr:CAB12312" /db_xref="GOA:P96652" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12122" /db_xref="UniProtKB/Swiss-Prot:P96652" /translation="MIDEIDKKILDELSKNSRLTMKKLGEKVHLTAPATASRVVKLID NGIIKGCSIEVNQVKLGFSIHAFLNIYIEKIHHQPYLAFIETQDNYVINNYKVSGDGC YLLECKFPSNEVLDQFLNDLNKHANYKVSIVIGK*" /label="lrpA CDS" gene 512575..512985 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /label="lrpA gene" S_feature 512986..513055 /Source="Nicolas_S_feature" /locus_tag="new_551930_551999" /HighExp="dia15, dia5, H2O2, HPh, G180, G135, LBGtran, Paraq, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S177" downshifts 513012 /Source="Nicolas_upshifts" /id="D240" /incds=0 /nref=45 /ntot=194 /MaxReadThrough="2.99689" /MaxDrop="3.6808" /score="-1.98969146" /energy="-15.7" /TU="U392" /idTUdmin="U392" /TUdmin="-350" /isTUend="FALSE" /label="downshifts" CDS complement(513108..513557) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388387.1" /db_xref="EnsemblGenomes-Gn:BSU05060" /db_xref="EnsemblGenomes-Tr:CAB12313" /db_xref="GOA:P96653" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12123" /db_xref="UniProtKB/Swiss-Prot:P96653" /translation="MQIDSIDFQILQLLNKNARIQWKEIGEKIHMTGQAVGNRIKKME DNGIIKAYSIVVDELKMGFSFTAFVFFFMNAYMHDDLLKFIATRNEISEAHRVSGDAC YLLKVTVHSQEVLNHLLNDLLKYGNYQLYLSIKEVKKHYNTSLMSDE*" /label="lrpB CDS" gene complement(513108..513557) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /label="lrpB gene" CDS 513672..514214 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388388.1" /db_xref="EnsemblGenomes-Gn:BSU05070" /db_xref="EnsemblGenomes-Tr:CAB12314" /db_xref="GOA:P96654" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12124" /db_xref="UniProtKB/Swiss-Prot:P96654" /translation="MTTALLVIDIQNDYFPNGKMALTNPEKAAQNAAKLLSHFRNTGA PVFHVQHITEGNIAHFFHPNTEGVEIHESVRPLEKETVIVKHMPNSFFNTDLNGKLQE EGVKELVVCGMMSHMCIDATVRSAVEHGYVCQVVEDACATTTLQIEDKIVPAEHVHYA FMAALNGVYATVKTTEAFLK*" /label="yddQ CDS" gene 513672..514214 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /label="yddQ gene" promotor_-35 514687..514691 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 514708..514727 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 514717 /Source="Nicolas_upshifts" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="upshifts" CDS 514767..515531 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388389.1" /db_xref="EnsemblGenomes-Gn:BSU05080" /db_xref="EnsemblGenomes-Tr:CAB12315" /db_xref="GOA:P96655" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12125" /db_xref="UniProtKB/Swiss-Prot:P96655" /translation="MNITQIRNATIVVKYANKKFLIDPMLAEKGTYATFPETIRQDLF NPLVSLPTSIDNILDGVDAVIVTHLHLDHFDDVAKNVLPKNIKMFVQNEADAKEVKAS GFKNVEVLHQDTVFEGIQLVKTKGEHGRGEELLNLMGDVCGLVFKHPSEKVLYVAGDT VWYDAIEDEIHTHQPEIIVVNGGDNQRLDLGSLIMGKEDIYEVHKAAPHAKIISVHME AVNHWTLSREELKNFSKEKGFSSNILVPEDGESYTF*" /label="yddR CDS" gene 514767..515531 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /label="yddR gene" CDS 515725..517035 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388390.1" /db_xref="EnsemblGenomes-Gn:BSU05090" /db_xref="EnsemblGenomes-Tr:CAB12316" /db_xref="GOA:P96656" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12126" /db_xref="UniProtKB/Swiss-Prot:P96656" /translation="MVMTKKDTNISTQQPLWLQGYIDSPEKQNQLYKKTLKILIFSQI FGGAGLGAGITVGALLAQDMIGSENVAGIPTALFTFGSAVAALLIGASSQRFGRRAGL AGGFLIGGLGAIGVIIAALINSVALLFVSLLIYGAGMASNLQVRYAGTDLANEKQRAT AASMALVSTTLGAVVGPNLVNTMGEFADSIGVPNLAGPFIMSGAAFIIAGIILLIFLR PDPLFVSTAIANAEKKDDKVQIGGSLKNPAIDKKGIMVGAVIMILAQLIMTAIMTMTP VHMGHHGHGLSEVGLVIGLHIAAMYLPSPLTGLLVDKFGRTTMAIASGATLLAAGLVA AIAPADSLSLLILALVLLGVGWNFGLLTGTALIIDSTHPSLRAKTQGTFDVLLALSGA AGGALSGMVVAHSSYTILSISGAVLSLLLIPVVIWYFRRIQEKA*" /label="yddS CDS" gene 515725..517035 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /label="yddS gene" S_feature 517058..517617 /Source="Nicolas_S_feature" /locus_tag="new_556002_556561" /HighExp="S8, C30, Cold, BMM, C90, GM 25, MG 15, M/G, LPh, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S178" CDS 517618..517794 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved phage protein of unknown function" /protein_id="YP_003097682.1" /db_xref="EnsemblGenomes-Gn:BSU05099" /db_xref="EnsemblGenomes-Tr:CAX52553" /db_xref="GOA:Q9K3A9" /db_xref="UniProtKB/Swiss-Prot:Q9K3A9" /translation="MNNKKNIFDIVMYIIFGVLSLFLVAKTDYGTGVLVFVAILYLAV IAYKIKQVFSNSDS*" /label="ydzM CDS" gene 517618..517794 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /label="ydzM gene" CDS 517819..518505 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported phage protein" /protein_id="NP_388391.1" /db_xref="EnsemblGenomes-Gn:BSU05100" /db_xref="EnsemblGenomes-Tr:CAB12317" /db_xref="SubtiList:BG12127" /db_xref="UniProtKB/Swiss-Prot:P96657" /translation="MRKKRVITCVMAASLTLGSLLPAGYASAKEDSKTTPSYEELALH YKMKSEKISSNGKLVEIEYVSGNETHKVQMNGNNHTVKVDGIEQKGLNFEYDENVAKR TNYENNNLKSNEFTTQAAKPKKGYHYVGTLSGHTKAAKNALSVTMSLVGIVPGLGWGS KAATILFSYWAKEQIPDAYYKYDLYEKGAMTDSWYQYATVQFFEDKAHKKKMGKPWTS TPAKVDLPNS*" /label="yddT CDS" gene 517819..518505 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /label="yddT gene" promotor_-35 518847..518851 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-35" promotor_-10 518866..518885 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-10" upshifts 518874 /Source="Nicolas_upshifts" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="upshifts" Polymorphism join(518921,518923) /Source="geneious" /ID="SNP_BsDelta6_557866_557865" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(T)5 -> (T)6" /Codon_Change /Coverage=35 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value="3.2e-123" /Variant_Raw_Frequency=35 /comment="ydzN_translation_signal_variant" /modified_by="User" / /label="Polymorphism_Delta6" CDS 518930..519115 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097683.1" /db_xref="EnsemblGenomes-Gn:BSU05109" /db_xref="EnsemblGenomes-Tr:CAX52554" /db_xref="GOA:C0H3V7" /db_xref="UniProtKB/Swiss-Prot:C0H3V7" /translation="MRWSKWFNVFCIVALGSIYGYKLFTNQEVSTTRLIIASVIVLWN IVGLFSKESVKQAQQAN*" /label="ydzN CDS" gene 518930..519115 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /label="ydzN gene" downshifts 519114 /Source="Nicolas_upshifts" /id="D241" /incds=0 /nref=9 /ntot=125 /MaxReadThrough="3.39785" /MaxDrop="3.7067" /score="-6.31330934" /energy="-12.8" /TU="U394" /idTUdmin="U394" /TUdmin="-1068" /isTUend="FALSE" /label="downshifts" CDS 519465..520058 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /experiment="publication(s) with functional evidences, PMID:24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase III homolog, deglycase" /protein_id="NP_388392.1" /db_xref="EnsemblGenomes-Gn:BSU05110" /db_xref="EnsemblGenomes-Tr:CAB12318" /db_xref="GOA:P96658" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="PDB:3F5D" /db_xref="SubtiList:BG12128" /db_xref="UniProtKB/Swiss-Prot:P96658" /translation="MKKALFLILDQYADWEGVYLASALNQREDWSVHTVSLDPIVSSI GGFKTSVDYIIGLEPANFNLLVMIGGDSWSNDNKKLLHFVKTAFQKNIPIAAICGAVD FLAKNGLLNNHSHTGNFVYLWKDYKQYKPISSFVEKQAVRDKNLVTANGTAPIEFTNL ILEMIDFDTPENIEKMMYMNRYGFYHFCDKYGNPFVD*" /label="sufLC CDS" gene 519465..520058 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /label="sufLC gene" promotor_-35 520171..520178 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 520192..520211 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 520203..520320 /Source="Nicolas_S_feature" /locus_tag="new_559146_559263" /HighExp="B60, LoTm, T5.0H, T3.30H, M9-stat, BI, BC, C90, T3.0H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S179" upshifts 520203 /Source="Nicolas_upshifts" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(520238) /Source="Nicolas_upshifts" /id="D242" /incds=0 /nref=10 /ntot=93 /MaxReadThrough="1.86628" /MaxDrop="4.19111" /score="25.1917407" /energy="-12.9" /TU="NA" /idTUdmin="U396" /TUdmin=328 /isTUend="FALSE" /label="downshifts" CDS 520321..520521 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9379903, 9914312, 9920884, 10517332, 11591689, 12427936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379903, 9914312, 9920884, 10517332, 11591689, 12427936; Product type f : factor" /codon_start=1 /transl_table=11 /product="cold-shock protein" /protein_id="NP_388393.1" /db_xref="EnsemblGenomes-Gn:BSU05120" /db_xref="EnsemblGenomes-Tr:CAB12319" /db_xref="GOA:P39158" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11024" /db_xref="UniProtKB/Swiss-Prot:P39158" /translation="MEQGTVKWFNAEKGFGFIERENGDDVFVHFSAIQSDGFKSLDEG QKVSFDVEQGARGAQAANVQKA*" /label="cspC CDS" gene 520321..520521 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /label="cspC gene" S_feature complement(520419..521207) /Source="Nicolas_S_feature" /locus_tag="new_559362_560150_c" /HighExp="LoTm, B60, Cold, M9-stat, LPhT, B36, Sw, BC, S8, Salt" /AntisenseName="cspC" /AntisenseCor="0.39074308987975698" /AntisenseRegPval="-10.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S180" downshifts 520424 /Source="Nicolas_upshifts" /id="D243" /incds=1 /nref=19 /ntot=179 /MaxReadThrough="8.05368" /MaxDrop="3.4464" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=242 /isTUend="FALSE" /label="downshifts" downshifts 520525 /Source="Nicolas_upshifts" /id="D244" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="5.78621" /MaxDrop="5.83905" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=343 /isTUend="FALSE" /label="downshifts" misc_RNA complement(520589..520667) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /product="putative small conserved untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="sncZ RNA" gene complement(520589..520667) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /label="sncZ gene" CDS complement(521208..521669) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26849219; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for repair and outgrowth of heat damaged spores" /protein_id="NP_388394.1" /db_xref="EnsemblGenomes-Gn:BSU05130" /db_xref="EnsemblGenomes-Tr:CAB12320" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG12129" /db_xref="UniProtKB/Swiss-Prot:P96659" /translation="MFQIGDNIVYPMHGAGIIEAIEEKEFLEEKQQYYVIRMSISNMT VMIPTSKILSSNIRPVTDILALKHIMHIFQHGESDRLLPWKQRYKINTDKIKTGEIQE GAEVVRDLMRMKKEKALNASEKKMLDNAYEFLISELEVIKGITEKQIKSFG*" /label="cdnL CDS" gene complement(521208..521669) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /label="cdnL gene" S_feature 521678..522223 /Source="Nicolas_S_feature" /locus_tag="new_560621_561166" /HighExp="Cold, G135, S8, G180, LoTm, S7, G150, HPh, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S181" upshifts complement(521721) /Source="Nicolas_upshifts" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(521728..521747) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(521763..521770) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 522190 /Source="Nicolas_upshifts" /id="D245" /incds=0 /nref=7 /ntot=141 /MaxReadThrough="0.289110000000001" /MaxDrop="4.3701" /score="26.1823933" /energy="-9.5" /TU="NA" /idTUdmin="U395" /TUdmin=864 /isTUend="FALSE" /label="downshifts" CDS complement(522237..522473) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388395.1" /db_xref="EnsemblGenomes-Gn:BSU05140" /db_xref="EnsemblGenomes-Tr:CAB12321" /db_xref="GOA:O31493" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12808" /db_xref="UniProtKB/Swiss-Prot:O31493" /translation="MYLGIVSTACAFLLWNHGLQLLNASSGGLFFFFQPLVGTLLGWI LLGEQIGGTFWIGSFLILSGVLLVIKEKEKEVKS*" /label="ydzE CDS" gene complement(522237..522473) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /label="ydzE gene" CDS complement(522571..523446) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388396.1" /db_xref="EnsemblGenomes-Gn:BSU05150" /db_xref="EnsemblGenomes-Tr:CAB12322" /db_xref="GOA:P96660" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG12130" /db_xref="UniProtKB/Swiss-Prot:P96660" /translation="MKNFVIDQNLKELTEHRTVELPVACYKTTINQNINGYIPLHWHD EIQFVLILKGIALFQINEEKIEVHEGDGLFINSGYLHMAEEKEGSDCTYICLNVSPHF VLSQELYSSYVQPYMFSTNLPYLFLAGNQQWAKNILDAVKKINQLIQQKTSLYEIDIT MQLTLMWKNLVVNGFQLEYDQSEMIKSHRMKQMLNWIHLHYVEKITLEDIAKAGQLSR SECCRYFKRMLNKTPLRYVMDYRIQKSLLLLQHPESNVTEVSYQVGFNSTSYFISKFQ QAMNMTPLSYKKMNS*" /label="ydeC CDS" gene complement(522571..523446) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /label="ydeC gene" CDS 523559..524518 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388397.1" /db_xref="EnsemblGenomes-Gn:BSU05160" /db_xref="EnsemblGenomes-Tr:CAB12323" /db_xref="GOA:P96661" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12131" /db_xref="UniProtKB/Swiss-Prot:P96661" /translation="MNTSNRRMGLFYVITGATCWGIGGTVAKKLFQEYQIDVNWLVTT RLLTAGMLLLMLQLFRKDRSQVIEVWKHKASAGQLLIFGLLGMLAVQYTYMASIQHGN AAVATLLQYLSPVIVIIYTLLRKQTVLTKQDIITVVLALVGCFFLLTNGSMSQLSVPA AAVVWGVLSGFAAAFYTLYAVGLLNKFDSLVVVGWAMIIGGFALGFIHPPWQLDFQRL TAEAYAYILFVILFGTMIAFWFFIKSLESLSPKETSLLGSLEPLSAVVTTVVWLKAPF GSFQWIGAICIIGITLILALHKEPSMESEKSILKIRNHANRDI*" /label="ydeD CDS" gene 523559..524518 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /label="ydeD gene" upshifts complement(523580) /Source="Nicolas_upshifts" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(523584..523603) /Source="Nicolas_upshift_promotors" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(524671..525543) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388398.1" /db_xref="EnsemblGenomes-Gn:BSU05170" /db_xref="EnsemblGenomes-Tr:CAB12324" /db_xref="GOA:P96662" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12132" /db_xref="UniProtKB/Swiss-Prot:P96662" /translation="MDLLKSMNRALKYIEENLTNDIDFQEAAKLAFCSEYHFKRMFSF LAGISLSEYIRRRRLTLAAFELKDSNVKVIDIAIKYGYNSPDSFARAFQNLHGINPSK ARFNGHSLKAYPRMTFQLTIKGGNEMNYRIEEKEAFRIVGIKKRVPIIFKGINPEIAS MWESLDEKAINKLKELSNVAPSGLISASTNFSEGRTEENGELDHYIGAATTKRCPDNF SRLEVPASTWAVFESIGPFPDTLQEVWGRIYSEWFPSSNYEQIEGPEILWNEHKDVTS PSFKSEIWIPITKK*" /label="ydeE CDS" gene complement(524671..525543) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /label="ydeE gene" promotor_-10 complement(525636..525641) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(525643..525644) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(525648) /Source="Nicolas_upshifts" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 525717..525723 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 525731 /Source="Nicolas_upshifts" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 525737..525756 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 525770..527158 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388399.2" /db_xref="EnsemblGenomes-Gn:BSU05180" /db_xref="EnsemblGenomes-Tr:CAB12325" /db_xref="GOA:P96663" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12133" /db_xref="UniProtKB/Swiss-Prot:P96663" /translation="MPINSFENYPMSWKPSIDKAEKPIYKALAGQLEQDILNGVLLPG TKLPPQRELADYLDLNVSTISKAFKVCELKGLLSATVGSGTFVSYDALSNAYLLEDTK PTHLIEMGAILPDHASYEPLLYQLKNMVHEEDYEKWFSYGRAGESLWQKDAAVKLIQR GGFETSVDHILFANGGQNAIAATLASLCKPGDRIGVDHHTYPGLKTVASLLSVQIVPI KSENDEMSPESLEYACKNENIKGLYLIPDYHNPTTSFMSVENRRMVADIVKKYNLFVI EDASYHLLNKNPLPALASFAPQQVIHIASLSKSLAPGLRLAYVAVPRQYKEPISKALY NLNITVSPLLAELTARTIVSNQFEVLIESHREQTIRRNQLVNRYVAGYTCLGVETGIF RWLLLPGKMSGAEFEELAARLGVQVYAAERFVVGNSCPERAVRVSVCAPKTLEELEQG LMILRRLLDDLT*" /label="ydeF CDS" gene 525770..527158 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /label="ydeF gene" downshifts 527134 /Source="Nicolas_upshifts" /id="D246" /incds=0 /nref=2 /ntot=61 /MaxReadThrough="0.91547" /MaxDrop="3.65963" /score="12.298375" /energy="-12.2" /TU="NA" /idTUdmin="U399" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS 527268..528560 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388400.1" /db_xref="EnsemblGenomes-Gn:BSU05190" /db_xref="EnsemblGenomes-Tr:CAB12326" /db_xref="GOA:P96664" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12134" /db_xref="UniProtKB/Swiss-Prot:P96664" /translation="MMLDKDSVKAIDVQTASLQSYISSPEKQKSLYKRTLFVVSISQI FGGAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGL SAGFMIGGLGAIGVIMAAIINSIFLLFISLLIYGAGTATNLQARYAGTDLANHKQRAT AVSITMVFTTFGAVAGPSLVNVMGDFALSIGVPSLAGPFILAAAAYMLAGVVLFIMLR PDPLVIARTIEAANEEPGDKGHLAATEHTENKKGIIVGATVMVLTQIVMVAIMTMTPV HMRHHGHDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAISSGTTLLLAGVIAA FAPGESMILLVIALSLLGLGWNFGLISGTALIVDSTDTATRAKTQGTVDVLIALSGAA GGALSGMIVAGSSYLALSLIGGILSLLLIPVVVWSRGR*" /label="ydeG CDS" gene 527268..528560 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /label="ydeG gene" promotor_-35 528569..528575 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 528590..528609 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 528597 /Source="Nicolas_upshifts" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="upshifts" S_feature 528608..528718 /Source="Nicolas_S_feature" /locus_tag="new_567551_567661" /HighExp="LoTm, T4.0H, T3.30H, T2.30H, T3.0H, T2.0H, T1.30H, T5.0H, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S182" CDS 528719..529165 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388401.1" /db_xref="EnsemblGenomes-Gn:BSU05200" /db_xref="EnsemblGenomes-Tr:CAB12327" /db_xref="GOA:P96665" /db_xref="SubtiList:BG12135" /db_xref="UniProtKB/Swiss-Prot:P96665" /translation="MNHIKWLSDLKKAGLLALGKGVITLLKRFSLVIVTLMMSIVVVL AAAKESPGDHVISFDEPIILMISIGIVVFLLIPPLVMSFFGNLVVRIISGVYQCFIVF TFLGLIPIGFLIPNGFLTILVSIAGTLVSIASVAVTLCIGKNKKDI*" /label="ydeH CDS" gene 528719..529165 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /label="ydeH gene" downshifts 529194 /Source="Nicolas_upshifts" /id="D247" /incds=0 /nref=200 /ntot=251 /MaxReadThrough="2.56495" /MaxDrop="6.50538" /score="-1.7193297" /energy="-4.5" /TU="NA" /idTUdmin="U400" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 529245..529252 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 529267..529286 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 529268 /Source="Nicolas_upshifts" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="upshifts" CDS 529402..529995 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16390439" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388402.1" /db_xref="EnsemblGenomes-Gn:BSU05210" /db_xref="EnsemblGenomes-Tr:CAB12328" /db_xref="InterPro:IPR014922" /db_xref="InterPro:IPR016786" /db_xref="SubtiList:BG12136" /db_xref="UniProtKB/Swiss-Prot:P96666" /translation="MTNSRTNPKVDEFLSKAKKWKEEFEKLRTIILDCELTEDFKWMH PCYTYHNKNIVLIHGFKEYCALLFHKGVLLQDTDGILIQQTENVQAARQIRFTNVQEI NELENILKAYIHEAIEVEKAGLKVDVNKNIELNIPEELQNKFDEIPALKIAFEALTPG RQRAYTLYFSQAKQSKTRESRVEKYVQKILDGKGLKD*" /label="ydeI CDS" gene 529402..529995 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /label="ydeI gene" downshifts 530038 /Source="Nicolas_upshifts" /id="D248" /incds=0 /nref=2 /ntot=40 /MaxReadThrough="1.63432" /MaxDrop="2.96785" /score="2.93671425" /energy="-6.9" /TU="NA" /idTUdmin="U401" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(530114) /Source="Nicolas_upshifts" /id="D249" /incds=0 /nref=1 /ntot=64 /MaxReadThrough="2.19009" /MaxDrop="2.9369" /score="-1.28013562" /energy="-6.9" /TU="NA" /idTUdmin="U403" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 530127..530134 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 530148 /Source="Nicolas_upshifts" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 530149..530168 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(530347..531006) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388403.1" /db_xref="EnsemblGenomes-Gn:BSU05220" /db_xref="EnsemblGenomes-Tr:CAB12329" /db_xref="GOA:P96667" /db_xref="SubtiList:BG12137" /db_xref="UniProtKB/Swiss-Prot:P96667" /translation="MKKRRKICYCNTALLLMILLAGCTDSKDGEAQQPSNQASAVQTD EKHTEPEESTKIRKDEAEPITESEESATKAANDTSSAEEKSKEDNVLAAYSSEKIEYA RVWLQLGPNQEIDELNVRHIAAGEPINPNDDTSASYPENVTQLAGSRLVDGSVTYHGN GDGTIHVYNVPLRWDSADDIEKGVMREVTESIIKNRKTVYVDTGDDEKIKRLIDIMMI H*" /label="ydeJ CDS" gene complement(530347..531006) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /label="ydeJ gene" promotor_-10 complement(531055..531074) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(531062) /Source="Nicolas_upshifts" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(531086..531091) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(531428..532291) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388404.1" /db_xref="EnsemblGenomes-Gn:BSU05230" /db_xref="EnsemblGenomes-Tr:CAB12330" /db_xref="GOA:P96668" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12138" /db_xref="UniProtKB/Swiss-Prot:P96668" /translation="MNKTTNGWINGFIGVLIFSGSLPATRLAVSDFDPLFLTVCRAAI AGVLAGGLLLIFRQQHPAKRDLISLLVVAFGVVIGFPLLTALALQHVTSAHAIVFIGL LPLATAVFGVLRGGERPRPVFWIFSAAGSLLVAGFALIQGGGSSPLGDAYMLASIVVC GLGYAEGAKLSRRLGNWQVISWALVLSLPLMLPLSFFFTPDSWSAIGVPALLSLAYVS LFSMLIGFVFWYRGLAQGGIAAVGQLQLLQPFFGLLLASVILHEKVGWALVAVNIAVI MCVAAARRFAK*" /label="ydeK CDS" gene complement(531428..532291) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /label="ydeK gene" promotor_-35 532334..532340 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 532355..532374 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(532356..532375) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 532370 /Source="Nicolas_upshifts" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(532380) /Source="Nicolas_upshifts" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(532390..532397) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 532446..533837 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /function="16.3: Control" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388405.1" /db_xref="EnsemblGenomes-Gn:BSU05240" /db_xref="EnsemblGenomes-Tr:CAB12331" /db_xref="GOA:P96669" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12139" /db_xref="UniProtKB/Swiss-Prot:P96669" /translation="MDITPFLNRTLDIPLYQQLYRYFKENMHRGRIQKGMKLPSKRLL ANQLSISQTTVERAYEQLAAEGYIVSKPRSGWFADYHDSDFAYDRMPSTTPIQQEAEE NKQWIDFHYGNVDSSYFPFSAWRKSMVNSLDQYGHELYRPGHVLGEFELRTLIAEYLY QSRGVHCGPEQVIIGAGNPILLQILCQVFEPNISIGYEDPGYPRARKIFEANRMNIVP IPVDDEGICIQKIKEQQPNLVYVTPSHQFTLGTIMTINRRIQLLKWAAENQSFIIEDD YDGEFRYTGQPVPSLQGLDQHNRVIYMGTFSKSLLPSLRISYMILPSPLLKKGHEITS LYKQTVSCHSQLTLAEFIKNGEWQKHINRMRKLYRKKRAIVLEAVQRELGEHVRIRGE NSGLRILLDVYLPFGEKELIEKAKKHGVKIYPVSLSYQHHPPTKTVSLGFAGVSESDI REGIKKLKAAWKI*" /label="ydeL CDS" gene 532446..533837 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /label="ydeL gene" promotor_-35 533965..533972 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-35" promotor_-10 533983..534002 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-10" upshifts 533997 /Source="Nicolas_upshifts" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="upshifts" CDS 534031..534456 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1556068, 26349822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase" /protein_id="NP_388406.1" /db_xref="EnsemblGenomes-Gn:BSU05250" /db_xref="EnsemblGenomes-Tr:CAB12332" /db_xref="InterPro:IPR002539" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12140" /db_xref="UniProtKB/Swiss-Prot:P96670" /translation="MKLDEFTIGQVFKTKSLKVSKDDIMRFAGEFDPQYMHVDEEKAS KGRFNGIIASGIQTLAISFKLWIEEGFYGDDIIAGTEMNHMTFIKPVYPDDELFTIVE VLDKQPKRNELGILTVLLSTYNQKEVKVFEGELSVLIKR*" /label="ydeM CDS" gene 534031..534456 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /label="ydeM gene" S_feature 534457..535711 /Source="Nicolas_S_feature" /locus_tag="new_573400_574654" /HighExp="G135, H2O2, G150, HiOs, G180, Cold, Paraq, UNK1, MG 15, LBGexp" /AntisenseName="ydeN" /AntisenseCor="0.40423774227585801" /AntisenseRegPval="-11.3" /CDS_PredictionProba="0.127641" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S183" CDS complement(534509..535081) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15159570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alpha/beta hydrolase" /protein_id="NP_388407.1" /db_xref="EnsemblGenomes-Gn:BSU05260" /db_xref="EnsemblGenomes-Tr:CAB12333" /db_xref="GOA:P96671" /db_xref="InterPro:IPR010662" /db_xref="InterPro:IPR029058" /db_xref="PDB:1UXO" /db_xref="SubtiList:BG12141" /db_xref="UniProtKB/Swiss-Prot:P96671" /translation="MTKQVYIIHGYRASSTNHWFPWLKKRLLADGVQADILNMPNPLQ PRLEDWLDTLSLYQHTLHENTYLVAHSLGCPAILRFLEHLQLRKQLGGIILVSGFAKS LPTLQMLDEFTQGSFDHQKIIESAKHRAVIASKDDQIVPFSFSKDLAQQIDAALYEVQ HGGHFLEDEGFTSLPIVYDVLTSYFSKETR*" /label="ydeN CDS" gene complement(534509..535081) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /label="ydeN gene" downshifts complement(534514) /Source="Nicolas_upshifts" /id="D250" /incds=0 /nref=16 /ntot=160 /MaxReadThrough="1.96868" /MaxDrop="3.80195" /score="2.50673989" /energy="-11.3" /TU="NA" /idTUdmin="U407" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(535082..535162) /Source="Nicolas_S_feature" /locus_tag="new_574025_574105_c" /HighExp="dia15, dia5, Diami, Etha, LPhT, Lbtran, Heat, H2O2, Sw, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S184" CDS complement(535163..535492) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388408.1" /db_xref="EnsemblGenomes-Gn:BSU05270" /db_xref="EnsemblGenomes-Tr:CAB12334" /db_xref="GOA:O31494" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12809" /db_xref="UniProtKB/Swiss-Prot:O31494" /translation="MNSLCRSKQAPFEYTLSLIGGKWKMRILYELGCEKTMRYGELKR AMPFITHKMLSAQLKELQTDGLIHRSEVSHTPLKVEYSLSDRGRSLYPLIDEMCKWGM AQGGPHM*" /label="ydzF CDS" gene complement(535163..535492) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /label="ydzF gene" misc_feature complement(535509..535528) /Source="Nicolas_upshift_promotors" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(535526) /Source="Nicolas_upshifts" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="upshifts" misc_feature 535700..535719 /Source="Nicolas_upshift_promotors" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 535713 /Source="Nicolas_upshifts" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="upshifts" CDS 535747..536619 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388409.1" /db_xref="EnsemblGenomes-Gn:BSU05280" /db_xref="EnsemblGenomes-Tr:CAB12335" /db_xref="GOA:P96672" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12142" /db_xref="UniProtKB/Swiss-Prot:P96672" /translation="MNTPKKHKKFKAKMILQIIMVIIGGIIAAYGLETVLIPNSVSDG GVTGLSIVGSQLFNLPLGILIAVINIPFVWLGYKQIGKSFALLSIIGIVSLAAGTSFF HHTPAIIEGDTLLITVVGGIILGFGMGLALRNGGALDGIDMLAVLLSRKLPFGTSDLI LFLNLFVFIFVSTVFGLQGALLSVIAYYIASKVIHVVEEGLSGSKTFQIITTQPELMV ETIRDQLGRSATYKEAYGGFSHEKFKEITCVINRLEETKLKEIINDIDKTAFVTVYDV AEVKGSNFRNLNHH*" /label="ydeO CDS" gene 535747..536619 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /label="ydeO gene" downshifts 536506 /Source="Nicolas_upshifts" /id="D251" /incds=1 /nref=7 /ntot=181 /MaxReadThrough="3.84278" /MaxDrop="2.68681" /score="15.0132064" /energy="-12.2" /TU="U408" /idTUdmin="U408" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" downshifts 536704 /Source="Nicolas_upshifts" /id="D252" /incds=0 /nref=54 /ntot=208 /MaxReadThrough="1.19842" /MaxDrop="3.77294" /score="15.0132064" /energy="-12.2" /TU="NA" /idTUdmin="U408" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(536769..537155) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388410.1" /db_xref="EnsemblGenomes-Gn:BSU05290" /db_xref="EnsemblGenomes-Tr:CAB12336" /db_xref="GOA:P96673" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12143" /db_xref="UniProtKB/Swiss-Prot:P96673" /translation="MRNRKLGIDYSSDDFEGCPVETTLDIIGGKWKGILLYHLIDGKK RFNEFRKLYPKITQRMLTLQLRELERDGVIHREVYKQVPPKVEYSLTEFGRTLEPVIL HMKDWGEKYKDRIDKLEAARKAEDKI*" /label="ydeP CDS" gene complement(536769..537155) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /label="ydeP gene" downshifts complement(536781) /Source="Nicolas_upshifts" /id="D253" /incds=0 /nref=29 /ntot=191 /MaxReadThrough="0.85093" /MaxDrop="4.4837" /score="-9.3516261" /energy="-12.9" /TU="NA" /idTUdmin="U409" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature complement(537156..537220) /Source="Nicolas_S_feature" /locus_tag="new_576099_576163_c" /HighExp="Diami, dia5, Salt, dia15, Etha, Heat, G180, HiOs, LBGexp, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S185" promotor_-35 537208..537215 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(537209..537228) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(537222) /Source="Nicolas_upshifts" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 537229..537248 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 537232 /Source="Nicolas_upshifts" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(537243..537250) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 537266..537859 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /EC_number="1.6.99.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase involved in regulating potassium efflux" /protein_id="NP_388411.1" /db_xref="EnsemblGenomes-Gn:BSU05300" /db_xref="EnsemblGenomes-Tr:CAB12337" /db_xref="GOA:P96674" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12144" /db_xref="UniProtKB/Swiss-Prot:P96674" /translation="MDHMKTLVLVVHPNIESSRINKKWKEAVLSEPDVTVHDLYEKYR DQPIDVEFEQQQLLAHDRIVFQFPLYWYSSPPLLKQWFDEVFTFGWAHGPGGNKLKGK EWVTAMSIGSPEHSYQAGGYNLFSISELTKPFQASAHLVGMTYLPSFAEYRANTISDQ EIAESANRYVKHITNIELNPKVRLQRYLKQLESVDLT*" /label="ydeQ CDS" gene 537266..537859 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /label="ydeQ gene" CDS complement(538003..539190) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388412.1" /db_xref="EnsemblGenomes-Gn:BSU05310" /db_xref="EnsemblGenomes-Tr:CAB12338" /db_xref="GOA:P96675" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12145" /db_xref="UniProtKB/Swiss-Prot:P96675" /translation="MANGNKQAGQRISPSLTLLLATACGIIVANLYYAQPLVGLISKA IGLSPSGAGLIVTLTQIGYVAGLLFLVPLGDIIENKKLIVVSLLLSAAALTLTAFVKH GTLFLAAAFFVGLGSIAAQVLVPFASYLASDAARGRVVGNVMSGLLLGIMLSRPISSL VADIWGWNAIFALSAVVSVILAIVLSKVLPARKPTANTNYTALLGSMWKLLRTTPVLR RRAIYHAFVFGAFSLFWTTVPLLLSGPDFHFSQKAIALYALVGIAGAVTAPIGGRLAD RGLTRLATGIALGVVVVSLLLPLMIQSSSPVGITVLVAAAILLDMGVSANLVLSQRAI FSLAPEIRSRLNGLFMAIFFLGGAIGSSIGGWAYASGGWSTALWIGIAFPVIALLYFI TEK*" /label="ydeR CDS" gene complement(538003..539190) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /label="ydeR gene" promotor_-35 539326..539330 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 539344 /Source="Nicolas_upshifts" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 539345..539364 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 539394..539990 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15944459; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388413.1" /db_xref="EnsemblGenomes-Gn:BSU05320" /db_xref="EnsemblGenomes-Tr:CAB12339" /db_xref="GOA:P96676" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011075" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12146" /db_xref="UniProtKB/Swiss-Prot:P96676" /translation="MQSKRGRPRDEGTHKAILSAAYDLLLEKGFDAVTVDKIAERAKV SKATIYKWWSNKAAVIMDSFLSTATDRLPVPDTGSSVQDIVTHATNLARFLTSREGTV IKELIGAGQLDEKLAEEYRTRFFQPRRLQAKGLLEKGIQKGELRENLDIEVSIDLIYG PIFYRLLITGDEVNDSYVRDLVMNAFKGVQATSATESM*" /label="ydeS CDS" gene 539394..539990 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /label="ydeS gene" CDS 540104..540289 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097684.1" /db_xref="EnsemblGenomes-Gn:BSU05329" /db_xref="EnsemblGenomes-Tr:CAX52555" /db_xref="UniProtKB/Swiss-Prot:C0H3V9" /translation="MSKKKSFNREYITSYYYIPFHRLEQGFYTSMEYRKVGVFKQQGK IDGHYVGVMAMEKILAM*" /label="ydzO CDS" gene 540104..540289 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /label="ydzO gene" downshifts 540268 /Source="Nicolas_upshifts" /id="D254" /incds=0 /nref=5 /ntot=123 /MaxReadThrough="1.06987" /MaxDrop="2.89833" /score="-5.04743481" /energy="-6.3" /TU="NA" /idTUdmin="U411" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 540401..540404 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 540411..540597 /Source="Nicolas_S_feature" /locus_tag="new_579354_579540" /HighExp="LBGstat, G180, LBGexp, G135, Paraq, G150, Oxctl, dia0, Diami, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S186" upshifts 540411 /Source="Nicolas_upshifts" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 540419..540438 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 540598..540933 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15948947, 16430705" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16430705; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (metals sensing ArsR-SmtB repressors family)" /protein_id="NP_388414.1" /db_xref="EnsemblGenomes-Gn:BSU05330" /db_xref="EnsemblGenomes-Tr:CAB12340" /db_xref="GOA:P96677" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12147" /db_xref="UniProtKB/Swiss-Prot:P96677" /translation="MTIDVAAMTRCLKTLSDQTRLIMMRLFLEQEYCVCQLVDMFEMS QPAISQHLRKLKNAGFVNEDRRGQWRYYSINGSCPEFDTLQLILHQIDQEDELLNHIK QKKTQACCQ*" /label="aseR CDS" gene 540598..540933 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /label="aseR gene" CDS 540946..542253 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12950922, 14970228, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arsenite/antimonite/H+ antiporter" /protein_id="NP_388415.1" /db_xref="EnsemblGenomes-Gn:BSU05340" /db_xref="EnsemblGenomes-Tr:CAB12341" /db_xref="GOA:P96678" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12148" /db_xref="UniProtKB/Swiss-Prot:P96678" /translation="MTSMILAVFIFLLTLVLVIWQPKNLSIGWSACGGAVLALIAGVV NFHDVLTVTGIVWNATLAFVAIILISLILDNIGFFEWAALHMAKAAKGYGVRMFVYVS LLGAIVAALFANDGAALILTPIVLAMVRALHFNEKLVFPFIIASGFIADTTSLPFVVS NLVNIVSADYFHITFIDYASRMVVPYLFSLLASIIVLYLFFRKSIPKRYDLTEVKKPV EAIKDQNMFRLSWYILGLLLIGYFASEFFSIPVSVVAGSIAIIFLIAAQKSPAVHTKK VVKEAPWAIVFFSIGMYVVVYGVRNAGLTDVLSDVIQAAADQGLFAGTIGMGFIAAIL SSIMNNLPTVMIDALAIAGTDTHGMMREALIYANVIGSDLGPKITPIGSLATLLWLHV LSHKGMKISWGTYFKTGIILTIPTLLITLVGLYIWLLIIHSCF*" /label="arsF CDS" gene 540946..542253 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /label="arsF gene" CDS 542285..542389 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of ydzS" /translation="CTGNSCRSQMAEGWGRKYLGAKWNVYSAGIEAQG*" /label="ydzSn CDS" gene 542285..542389 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /pseudo /label="ydzSn gene" CDS 542398..542511 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of ydzS" /translation="AVKAMKEAGIDISNQTSEKFDDPAKAHGTEEVFPKGP*" /label="ydzSc CDS" gene 542398..542511 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /pseudo /label="ydzSc gene" promotor_-35 542697..542705 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 542716..542734 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 542733 /Source="Nicolas_upshifts" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 542751..543536 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388416.1" /db_xref="EnsemblGenomes-Gn:BSU05350" /db_xref="EnsemblGenomes-Tr:CAB12342" /db_xref="GOA:P96679" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR027365" /db_xref="SubtiList:BG12149" /db_xref="UniProtKB/Swiss-Prot:P96679" /translation="MSVLQELTKKKYSSLKTMFDDKYCPTFVYSILDQTIPGAVYADD QTFPKSFFIGTESGIYFIAGDQGNRDFHDFIAGYYEEQVKSSKRFTLFSSSDTWDSVL KPILKDDLNQMRRAAFSYQPKSFKKTLQLPKGLVLKRIDEDIISHSTAFNSAYYEEYW NSVSQFASKGFGFAVLHGNHVVSECTSIFLGHNRAEMDIYTLEEYRGLGLAYCVANRF IAFCMENGIVPSWDCDICNNSSIALAAKLGFKTVTEYTIYYSG*" /label="ydfB CDS" gene 542751..543536 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /label="ydfB gene" downshifts 542798 /Source="Nicolas_upshifts" /id="D255" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="2.67554" /MaxDrop="5.08398" /score="39.1565399" /energy="-19.2" /TU="NA" /idTUdmin="U413" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 543546 /Source="Nicolas_upshifts" /id="D256" /incds=0 /nref=2 /ntot=90 /MaxReadThrough="0.161840000000001" /MaxDrop="3.51451" /score="-0.169292431" /energy="-13.6" /TU="NA" /idTUdmin="U413" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS complement(543593..544513) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid exporter" /protein_id="NP_388417.1" /db_xref="EnsemblGenomes-Gn:BSU05360" /db_xref="EnsemblGenomes-Tr:CAB12343" /db_xref="GOA:P96680" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12150" /db_xref="UniProtKB/Swiss-Prot:P96680" /translation="MRKKTVQIMISHSLMIGLWASAFPGIRAGLEGYTPEHLALFRLL IGSMALLLFAVLTQMRLPDLKDIPAIFLLGFLGFAFYHILLNIGEKTVSAGVASLLVT TAPIFSAMLSRLFYKEHFGFTKWLGSMISLLGVLLIAFGAGDFTYSMSGILVILLAAF SESIYFVFQARYIKKYGFIPFVTFTIWGGTIPMLVFLPGLGEEMMNASISATLSIVYL GLLPTVIPYFALAYVTSFVGASEATLSLYVTPALALIISWLWIGEIPTLLSLLGGVVT VGGVCFTYLKVNKMNKIFITHFSAKRVKKL*" /label="ydfC CDS" gene complement(543593..544513) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /label="ydfC gene" CDS 544646..546094 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388418.1" /db_xref="EnsemblGenomes-Gn:BSU05370" /db_xref="EnsemblGenomes-Tr:CAB12344" /db_xref="GOA:P96681" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12151" /db_xref="UniProtKB/Swiss-Prot:P96681" /translation="MSFPEEKKMKKLPKYRQIVHFIKEKIGNGEWPIGSKIPSQRTLA KDFQVNRSTVITALEELMADGLIEGTMGKGTVVINNTWTLMAKNSAPDWDQYVTSGIQ MPSRKIVQEINQSESNTDLIQLSKGELSAEIFPLAVMKEMMGKVSQHMEAFGYEEPKG YLPLREALSNYLKTIGINVSSSSILIVSGALQALQLISMGLLQRGSTVYLDQPSYLYS LHVFQSAGMKLTGLPMDNEGLLPENVHLTRGERGRAILYTNPCFHNPTGILMSKKRRE EILAVSENTQLPIIEDDIYRELWIDEIPPYPIKTIDKNGHVLYIGSLSKTLSPGLRIG WIVGPEPVIERLSDIKMQTDYGSSSLSQRVAAEWFTSGHYQQHVEKVRQQLKVRRELA LSALETHLKEVATWNIPKGGFFVWIKILPSISMKLLYTKALSKGILINLGSIYAQEKG NYIRLSYAYASLEDLQKGIYELGLMIKELASR*" /label="ydfD CDS" gene 544646..546094 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /label="ydfD gene" CDS complement(546212..546835) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavoprotein" /protein_id="NP_388419.1" /db_xref="EnsemblGenomes-Gn:BSU05380" /db_xref="EnsemblGenomes-Tr:CAB12345" /db_xref="GOA:P96682" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12152" /db_xref="UniProtKB/Swiss-Prot:P96682" /translation="MDIKKQDTRRFKEIKPKIMYYGTSTFLLTTLNEDGTTNISPMSS SWALGHYIILGVGLGGKAIDNLERHKECVINLPGPDLWENVERISSYSGKKSIPPLKK QIGFTYKKEKYEAAGLTPLQSKTVSPTRIKECPIQIEAEVKHIRLPEYESSFAIVETQ ALHFHAEESIILDENHINPSKWSPLIYNFRHYFGLGREVGKTFRSET*" /label="ydfE CDS" gene complement(546212..546835) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /label="ydfE gene" promotor_-10 complement(546859..546878) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 546867..546874 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(546878) /Source="Nicolas_upshifts" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 546889..546908 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 546891 /Source="Nicolas_upshifts" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(546893..546899) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 546925..547605 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388420.1" /db_xref="EnsemblGenomes-Gn:BSU05390" /db_xref="EnsemblGenomes-Tr:CAB12346" /db_xref="GOA:P96683" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12153" /db_xref="UniProtKB/Swiss-Prot:P96683" /translation="MNPNIAKISSLLSDPSRSSILLSLMDGRIHPAGELAYLANIKPQ TASFHLNKLLEAKLISVEKHGRHRYYRLADSDAANVIEQLLHIAPKAKVKSLKESKEK KDLHFARTCYDHLAGYVGVQMAHSLVEQGMLKKVDLNFEVTSEGALFFSKLGINEEQQ RNKRRAFARCCLDWSERQHHIAGALGNALLVRMLEEEWIVRMPKTRAIRITQSGKIAF EKHLNVKI*" /label="ydfF CDS" gene 546925..547605 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /label="ydfF gene" downshifts 547638 /Source="Nicolas_upshifts" /id="D257" /incds=0 /nref=113 /ntot=245 /MaxReadThrough="0.50202" /MaxDrop="4.24716" /score="-7.74889591" /energy="-4.5" /TU="U415" /idTUdmin="U415" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(547685..548128) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388421.1" /db_xref="EnsemblGenomes-Gn:BSU05400" /db_xref="EnsemblGenomes-Tr:CAB12347" /db_xref="GOA:P96684" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR004675" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG12154" /db_xref="UniProtKB/Swiss-Prot:P96684" /translation="MSQRVSYYEIAPEGMKIMMDMEKYTKQSSINRTTRELIKIRVSQ MNGCAFCIDMHTSDARKMGETEQRIYCLHAWNECDFYSPEEKAALELSEHITLIPSKR VPDELYHRVREHYDEEQYVDLVLIINQINSWNRISIAMGNRAASK*" /label="ydfG CDS" gene complement(547685..548128) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /label="ydfG gene" downshifts complement(547690) /Source="Nicolas_upshifts" /id="D258" /incds=0 /nref=10 /ntot=187 /MaxReadThrough="1.76648" /MaxDrop="3.73786" /score="0.225628164" /energy="-10.8" /TU="NA" /idTUdmin="U416" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(548151..548170) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(548175) /Source="Nicolas_upshifts" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(548184..548191) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(548214..548393) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097685.1" /db_xref="EnsemblGenomes-Gn:BSU05408" /db_xref="EnsemblGenomes-Tr:CAX52558" /db_xref="GOA:C0H3W0" /db_xref="UniProtKB/Swiss-Prot:C0H3W0" /translation="MNMYWFLGALLYFLIGTYIFIRVTRDSQSGSWILLALAAPLIIA GYPYFYSKKLLSKRR*" /label="ydzP CDS" gene complement(548214..548393) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /label="ydzP gene" CDS complement(548390..548533) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097686.1" /db_xref="EnsemblGenomes-Gn:BSU05409" /db_xref="EnsemblGenomes-Tr:CAX52559" /db_xref="UniProtKB/Swiss-Prot:C0H3W1" /translation="MKSIDLTILSLKRKGIRTEKVLKNQNPDRLSHMTDKNAQPKSKE KEE*" /label="ydzQ CDS" gene complement(548390..548533) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /label="ydzQ gene" promotor_-35 548484..548486 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 548502..548521 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 548518 /Source="Nicolas_upshifts" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 548801..550024 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YdfI]" /protein_id="NP_388422.1" /db_xref="EnsemblGenomes-Gn:BSU05410" /db_xref="EnsemblGenomes-Tr:CAB12348" /db_xref="GOA:P96685" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12155" /db_xref="UniProtKB/Swiss-Prot:P96685" /translation="MLIRNPFKDKYYSHDRRALNMLALRVPGLAFILMIYIASIVLQF VSGGWSILLLYAFTILIAIFALLHWHSYRWVKKRVILYFAVQGLITFALANLMTGFFI LVIIGLYAFLIGQIIGMADRRRTFLILYLLLLLVINSAYHLHKGEVLHFIVIAAPIMI VIITYAATFFAQVDEKIKAQLTLERLELAHQQVEQLTLQNERQRMARDLHDTLAQGLV SLNMQLDAIHVHLAKGNTERAKEIIQQSMKRVKSTIADARSAIDDLRSKSEEIGVLKE RITSLMDHFIESTGMACLLDYRLHQVLDVRTAENCYYIIGECMTNAAKHAEAKTIWIS IWDDEKGRLHLTVKDNGKGFDVEKGKKKRGHYGLLGIQERVRAINGQFNIKSTKLKGT QIEITVPIQGEMQDE*" /label="ydfH CDS" gene 548801..550024 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /label="ydfH gene" CDS 550017..550658 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YdfH]" /protein_id="NP_388423.1" /db_xref="EnsemblGenomes-Gn:BSU05420" /db_xref="EnsemblGenomes-Tr:CAB12349" /db_xref="GOA:P96686" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12156" /db_xref="UniProtKB/Swiss-Prot:P96686" /translation="MNKVLIVDDHLVVREGLKLLIETNDQYTIIGEAENGKVAVRLAD ELEPDIILMDLYMPEMSGLEAIKQIKEKHDTPIIILTTYNEDHLMIEGIELGAKGYLL KDTSSETLFHTMDAAIRGNVLLQPDILKRLQEIQFERMKKQRNETQLTEKEVIVLKAI AKGLKSKAIAFDLGVSERTVKSRLTSIYNKLGANSRTEAVTIAMQKGILTIDN*" /label="ydfI CDS" gene 550017..550658 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /label="ydfI gene" downshifts 550652 /Source="Nicolas_upshifts" /id="D259" /incds=0 /nref=5 /ntot=147 /MaxReadThrough="1.15378" /MaxDrop="2.65603" /score="8.33575703" /energy="-6.4" /TU="NA" /idTUdmin="U419" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(550685..550704) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(550706) /Source="Nicolas_upshifts" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(550718..550725) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 550766..550771 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 550774..552948 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941986; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative proton metabolite efflux transporter" /protein_id="NP_388424.1" /db_xref="EnsemblGenomes-Gn:BSU05430" /db_xref="EnsemblGenomes-Tr:CAB12350" /db_xref="GOA:P96687" /db_xref="InterPro:IPR000731" /db_xref="InterPro:IPR004869" /db_xref="SubtiList:BG12157" /db_xref="UniProtKB/Swiss-Prot:P96687" /translation="MSKMLYTLGGWVARNRIKAICAWIVVLVAAIGLAVTLKPSFSED MSIPDTPSEKAMDVIQKEFPHGPDKGSIRVIFGAGDGEKLTGKPAKKAIEDTFKEISK DDSVDSIASPFVTGTIAKDGTVAYADIQYKSSADDIKDYSIKHLKDSLKMADDEGLQT ELSGDVPGAEMEIGGVSEIVGIILAFVVLAITFGSLLIAGLPILTALIGLGVSIGLVL IGTQVFDIASVSLSLAGMIGLAVGIDYALFIFTKHRQFLGEGIQKNESIARAVGTAGS AVVFAGLTVIVALCGLTVVNIPFMSAMGLTAGLSVLMAVLASITLVPAVLSIAGKRMI PKSNKKIEKQSTETNVWGRFVTKNPIMLSVCSILILIVISIPSMHLELGLPDAGMKAK DNPDRRAYDLLAEGFGEGFNGQLTIVADATNATENKAEAFADAVKEIKGLDHVASVTP AMPNKEGNFAIITVVPETGPNDVTTKDLVHDVRSLSDKNGVDLLVTGSTAVNIDISDR LNDAIPVFAVLIVGFAFVLLTIVFRSLLVPLVAVAGFMLTMTATLGICVFVLQDGNLI DFFKIPEKGPILAFLPILSIGILFGLAMDYQVFLVSRMREEYVKTNNPVQAIQAGLKH SGPVVTAAGLIMIFVFAGFIFAGEASIKANGLALSFGVLFDAFIVRMTLIPSVMKLMG NAAWYLPKWLDKIIPNVDIEGHQLTKEIQPEIDHEQKKQISV*" /label="ydfJ CDS" gene 550774..552948 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /label="ydfJ gene" upshifts 550784 /Source="Nicolas_upshifts" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 550786..550804 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(551850..551868) /Source="Nicolas_upshift_promotors" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(551850) /Source="Nicolas_upshifts" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(552952..553359) /Source="Nicolas_S_feature" /locus_tag="new_591895_592302_c" /HighExp="Paraq, H2O2, Oxctl, aero, LBGexp, dia15, GM 150, M/G, ferm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S187" promotor_-35 552969..552973 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 552983 /Source="Nicolas_upshifts" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 552986..553005 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(552997) /Source="Nicolas_upshifts" /id="D260" /incds=0 /nref=22 /ntot=134 /MaxReadThrough="-0.100210000000001" /MaxDrop="3.637" /score="4.29161871" /energy="-8.8" /TU="NA" /idTUdmin="U422" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(553360..554262) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7765103, 22248594, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7765103, 22248594, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase NP" /protein_id="NP_388425.1" /db_xref="EnsemblGenomes-Gn:BSU05440" /db_xref="EnsemblGenomes-Tr:CAB12351" /db_xref="GOA:P96688" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:2R11" /db_xref="SubtiList:BG11957" /db_xref="UniProtKB/Swiss-Prot:P96688" /translation="MSNHSSSIPELSDNGIRYYQTYNESLSLWPVRCKSFYISTRFGQ THVIASGPEDAPPLVLLHGALFSSTMWYPNIADWSSKYRTYAVDIIGDKNKSIPENVS GTRTDYANWLLDVFDNLGIEKSHMIGLSLGGLHTMNFLLRMPERVKSAAILSPAETFL PFHHDFYKYALGLTASNGVETFLNWMMNDQNVLHPIFVKQFKAGVMWQDGSRNPNPNA DGFPYVFTDEELRSARVPILLLLGEHEVIYDPHSALHRASSFVPDIEAEVIKNAGHVL SMEQPTYVNERVMRFFNAETGISR*" /label="cesA CDS" gene complement(553360..554262) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /label="cesA gene" S_feature complement(554263..554358) /Source="Nicolas_S_feature" /locus_tag="new_593206_593301_c" /HighExp="nit, ferm, aero, LoTm, M/G, GM 150, Diami, Paraq, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S188" promotor_-10 complement(554338..554357) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(554358) /Source="Nicolas_upshifts" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(554371..554378) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(554464..555153) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10200972, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388426.1" /db_xref="EnsemblGenomes-Gn:BSU05450" /db_xref="EnsemblGenomes-Tr:CAB12352" /db_xref="GOA:P96689" /db_xref="InterPro:IPR007563" /db_xref="SubtiList:BG12158" /db_xref="UniProtKB/Swiss-Prot:P96689" /translation="MFGTIFNTVMIIAGSIIGGIFKKGIKDEYQDILMQAMGFAAVAL GINAITQHLPDSKYPILFIVSLAIGGLLGQIINLELRFNKLVNKFSKSNLAEGLSTAV LLFCIGSLSILGPVEAALHGDYTYLLTNGMLDGITSIVLASTFGFGIAAAALVLFSWQ GSIYLFAQVMESAINTDLINEITIVGGILILSSGLSILGIKKFKTLNLLPSLLIPPVV IFVIHAFGLRF*" /label="ydfK CDS" gene complement(554464..555153) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /label="ydfK gene" CDS complement(555243..556055) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of efflux transporter" /protein_id="NP_388427.1" /db_xref="EnsemblGenomes-Gn:BSU05460" /db_xref="EnsemblGenomes-Tr:CAB12353" /db_xref="GOA:P96690" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12159" /db_xref="UniProtKB/Swiss-Prot:P96690" /translation="MKEFFSIGEVSKLFNVKISALRYYDEIGLLKPEYKDEQTNYRYY STQQFERLDTIKYLRALGLPINKLLDFYNSQNTNTLLHLLKSQQVEIDRKKKELERIE RKISRRITHIEDAVNMPLHQISKIKLPAMRVAYLQHEYVLGHDIEHSLAELRTHLNVN EDIFIGKIGLSISAANVKAKQFDKYSSIFMILEDENEKTSSEIIFPSREYLQIRFKGS HPEAEPYYKKLLAYMKEHHYEVAGDSIEITLIDYGITNNLDNYVTEILLPIK*" /label="ydfL CDS" gene complement(555243..556055) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /label="ydfL gene" promotor_-10 complement(556084..556103) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(556097) /Source="Nicolas_upshifts" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(556119..556126) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(556166..557059) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="primary Mn(II) efflux pump" /protein_id="NP_388428.2" /db_xref="EnsemblGenomes-Gn:BSU05470" /db_xref="EnsemblGenomes-Tr:CAB12354" /db_xref="GOA:C0SP78" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12160" /db_xref="UniProtKB/Swiss-Prot:C0SP78" /translation="MASEREQISRKVALIALIANLILMAGKVFFGLVGDSEAVFADGI HSAADVVASIAVLAVIGISNKPPDQDHPFGHGKAEVISEAIVGIILVIVSVYILIEAI LSFVKGPSVPQYSALFAALISYVAKEILYRYSIKQGKKWNSKAIIAIAYDHKGDIVAS LAAFIGVLLAIIGNSRGWSYLLYADAIASAIVAYLIFKISMELIRPSVDVLMEKSVDP ELIEEYKAVIFQCDQVKRIDRIRAREHGHYKLLDVRLSLDHDLTIKQGHDIAREIRNE IKRQFSDVEEVLIHVNPYFEE*" /label="mneP CDS" gene complement(556166..557059) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /label="mneP gene" downshifts complement(556186) /Source="Nicolas_upshifts" /id="D261" /incds=0 /nref=23 /ntot=121 /MaxReadThrough="1.07979" /MaxDrop="4.0938" /score="12.079524" /energy="-6.2" /TU="NA" /idTUdmin="U424" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(557060..557152) /Source="Nicolas_S_feature" /locus_tag="new_596003_596095_c" /HighExp="LPh, HPh, LPhT, UNK1, MG t5, MG 5, MG 15, BMM, GM 120, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S189" promotor_-10 complement(557133..557152) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(557150) /Source="Nicolas_upshifts" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(557168..557175) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 557341..557348 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 557363..557382 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 557369 /Source="Nicolas_upshifts" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" CDS 557535..558155 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388429.1" /db_xref="EnsemblGenomes-Gn:BSU05480" /db_xref="EnsemblGenomes-Tr:CAB12355" /db_xref="GOA:P96692" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="PDB:3BEM" /db_xref="SubtiList:BG12161" /db_xref="UniProtKB/Swiss-Prot:P96692" /translation="MAEFTHLVNERRSASNFLSGHPITKEDLNEMFELVALAPSAFNL QHTKYVTVLDQDVKEKLKQAANGQYKVVSSSAVLLVLGDKQAYQQAADIYEGLKVLGI LNKQEYDHMVQDTVSFYENRGEQFKRDEAIRNASLSAMMFMLSAKEKGWDTCPMIGFD AEAVKRILNIDDQFEVVMMITIGKEKTESRRPRGYRKPVNEFVEYM*" /label="ydfN CDS" gene 557535..558155 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /label="ydfN gene" promotor_-35 557879..557885 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 557890 /Source="Nicolas_upshifts" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 557899..557917 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 558171..559109 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /EC_number="1.13.11.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dioxygenase" /protein_id="NP_388430.1" /db_xref="EnsemblGenomes-Gn:BSU05490" /db_xref="EnsemblGenomes-Tr:CAB12356" /db_xref="GOA:P96693" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:3OAJ" /db_xref="SubtiList:BG12162" /db_xref="UniProtKB/Swiss-Prot:P96693" /translation="MAKKTMGIHHITAIVGHPQENTDFYAGVLGLRLVKQTVNFDDPG TYHLYFGNEGGKPGTIITFFPWAGARQGVIGDGQVGVTSYVVPKGAMAFWEKRLEKFN VPYTKIERFGEQYVEFDDPHGLHLEIVEREEGEANTWTFGEVTPDVAIKGFGGATLLS EQPDKTADLLENIMGLERVGKEGDFVRYRSAGDIGNVIDLKLTPIGRGQMGAGTVHHI AWRANDDEDQLDWQRYIASHGYGVTPVRDRNYFNAIYFREHGEILFEIATDPPGFAHD ETQETMGEKLMLPVQYEPHRTQIEQGLLPFEVRELD*" /label="ydfO CDS" gene 558171..559109 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /label="ydfO gene" promotor_-35 559097..559100 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 559115..559134 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 559122..559210 /Source="Nicolas_S_feature" /locus_tag="new_598065_598153" /HighExp="Etha, BT, S6, S7, S8, G/S, GM 10, Gly, GM 15, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB, SigA" /TUshortPSig="0.658, 0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S190" upshifts 559122 /Source="Nicolas_upshifts" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" CDS 559211..559600 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15306018, 15849754, 16850406, 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound oxidoreductase" /protein_id="NP_388431.1" /db_xref="EnsemblGenomes-Gn:BSU05500" /db_xref="EnsemblGenomes-Tr:CAB12357" /db_xref="GOA:P96694" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12163" /db_xref="UniProtKB/Swiss-Prot:P96694" /translation="MEDAGLLLIRIMIGVVFLFYGTQKLFGWFGGYGIKGTGQWFESI GVKPGNVAAALSGLGELVSGILFILGVFLPLGAAIITIIMLGAIVKVHGAKGFANGAG GFEYNLVLIAVSIGVALIGSGAYALHF*" /label="ydfP CDS" gene 559211..559600 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /label="ydfP gene" downshifts 559591 /Source="Nicolas_upshifts" /id="D262" /incds=0 /nref=3 /ntot=91 /MaxReadThrough="1.0642" /MaxDrop="3.85597" /score="-8.69038499" /energy="-9.3" /TU="NA" /idTUdmin="U427" /TUdmin=29 /isTUend="FALSE" /label="downshifts" misc_feature 559714..559733 /Source="Nicolas_upshift_promotors" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 559716..559785 /Source="Nicolas_S_feature" /locus_tag="new_598659_598728" /HighExp="Diami, dia5, H2O2, dia15, Etha, S8, Paraq, Salt, LPhT, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S191" upshifts 559716 /Source="Nicolas_upshifts" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 559786..560124 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388432.1" /db_xref="EnsemblGenomes-Gn:BSU05510" /db_xref="EnsemblGenomes-Tr:CAB12358" /db_xref="GOA:P96695" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12164" /db_xref="UniProtKB/Swiss-Prot:P96695" /translation="MKEMTGLHSLVSIENFIKQHKFSFIYISRPGCTVCHAVLPQLRI VLDQFPNIKLGHINADDVAEVAGRFSVFTVPVLLLFIDGTEFLREARFVHFEQLEQKL KRVYRLYEGE*" /label="ydfQ CDS" gene 559786..560124 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /label="ydfQ gene" downshifts 560112 /Source="Nicolas_upshifts" /id="D263" /incds=0 /nref=9 /ntot=28 /MaxReadThrough="1.76745" /MaxDrop="4.78737" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(560164..560400) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="NP_388433.1" /db_xref="EnsemblGenomes-Gn:BSU05520" /db_xref="EnsemblGenomes-Tr:CAB12359" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12810" /db_xref="UniProtKB/Swiss-Prot:O31496" /translation="MRSQINISNLTINGMTQNANTDIGQNLQNSHTANSKNYGVNFTL GDYSPSHSIIISASCDNDTSDQGQVDNPSSPSEE*" /label="ydzH CDS" gene complement(560164..560400) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /label="ydzH gene" downshifts complement(560188) /Source="Nicolas_upshifts" /id="D264" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.87679" /MaxDrop="2.5881" /score="9.38580075" /energy="-6" /TU="NA" /idTUdmin="U430" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-35 560212..560218 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 560233..560244 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 560244 /Source="Nicolas_upshifts" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(560401..560562) /Source="Nicolas_S_feature" /locus_tag="new_599344_599505_c" /HighExp="BT, B36, S8, S7, G135, S5, S6, G180, Pyr, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S192" S_feature complement(560566..560931) /Source="Nicolas_S_feature" /locus_tag="new_599509_599874_c" /HighExp="BT, B36, S8, S7, S6, G/S, S5, Pyr, B60, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigGF, SigK" /TUshortPSig="0.994, 0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S193" downshifts complement(560606) /Source="Nicolas_upshifts" /id="D265" /incds=0 /nref=26 /ntot=52 /MaxReadThrough="2.64253" /MaxDrop="4.6761" /score="8.29803249" /energy="-12.4" /TU="NA" /idTUdmin="U430" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(560932..561162) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="YP_003097687.1" /db_xref="EnsemblGenomes-Gn:BSU05529" /db_xref="EnsemblGenomes-Tr:CAX52560" /db_xref="InterPro:IPR019618" /db_xref="UniProtKB/Swiss-Prot:C0H3W2" /translation="MMKFPVYIHSISGNSVFNNGFAVSISPFSVSKTTEGSGGSNTGL VFESNALSQTSSANQAQNVTYAIQELLSKLLA*" /label="ydzR CDS" gene complement(560932..561162) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /label="ydzR gene" downshifts 561146 /Source="Nicolas_upshifts" /id="D266" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.08051" /MaxDrop="3.36374" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(561183..561202) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(561200) /Source="Nicolas_upshifts" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(561202..561285) /Source="Nicolas_S_feature" /locus_tag="new_600145_600228_c" /HighExp="S8, S5, S7, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK" /TUshortPSig="0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S194" promotor_-35 complement(561216..561225) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(561286..561963) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_388434.1" /db_xref="EnsemblGenomes-Gn:BSU05530" /db_xref="EnsemblGenomes-Tr:CAB12360" /db_xref="GOA:P96696" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12165" /db_xref="UniProtKB/Swiss-Prot:P96696" /translation="MNRLPFGYIKLRLAGRKANPMTNLIHHWSGGSMNFTWESLVLIV AGVILLRISGRKSIAQMTSTQTVVMISIGTIIVQPIIEYSLFKTLIAAAIFTSTLIVM EWIQMKSNTIEKMLTGKAKIVIENGQLHIENLKKMRLTADQLEMQLRLHGVTAIQDVK IATLEANGQLGIELTDDAKPLTVRDLKKLIHPDFINKDGQAQSGNQNIFDEVGKKNKK NVPKKLH*" /label="ydfR CDS" gene complement(561286..561963) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /label="ydfR gene" promotor_-10 complement(561934..561945) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(561948) /Source="Nicolas_upshifts" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(561960..561966) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(561964..562797) /Source="Nicolas_S_feature" /locus_tag="new_600907_601740_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, nit, B60" /AntisenseName="ydfS" /AntisenseCor="0.65823831974361602" /AntisenseRegPval="-34.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S195" promotor_-35 561979..561984 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 561999..562010 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 562004 /Source="Nicolas_upshifts" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="upshifts" CDS 562076..562783 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388435.1" /db_xref="EnsemblGenomes-Gn:BSU05540" /db_xref="EnsemblGenomes-Tr:CAB12361" /db_xref="GOA:P96697" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12166" /db_xref="UniProtKB/Swiss-Prot:P96697" /translation="MIELEVVIRTVASFGLLLIAERILGKQTISQMTIFDFIAAITLG AIAAGLAYNTSIKPHNMAISFSIFVLTIFLISFLSIKNRKLRKFFAGDPTVLIQNGKI LESNMRKMRYTLDYLNQQLREKEIFNIEEVLFAILETNGQLTVLRKPQFRHVTKQDLM IAVNQEQRLPIELIMDGEIIENNLKQNRLTESWLLEELRKRDIKVKETVYAVLLGNGD IYVDQYKDHISVPMDKE*" /label="ydfS CDS" gene 562076..562783 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /label="ydfS gene" CDS complement(562798..563229) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11150673; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_388436.1" /db_xref="EnsemblGenomes-Gn:BSU05550" /db_xref="EnsemblGenomes-Tr:CAB12362" /db_xref="GOA:P96698" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG12167" /db_xref="UniProtKB/Swiss-Prot:P96698" /translation="MDFEKIRKWLEITNEYKQSDFWTNVLKYKAPEHFFDSEASTFVY DFYQDEEYNFIIVEMPGVYEEELTIRLLSKTQLLIKGTITPVFPAEMEVLRERYYGEI ERIIQLPEAAETHLLQIQLLNGLLHISYPRQVETVAFNKGL*" /label="cotP CDS" gene complement(562798..563229) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /label="cotP gene" CDS complement(563242..563484) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388437.1" /db_xref="EnsemblGenomes-Gn:BSU05560" /db_xref="EnsemblGenomes-Tr:CAB12363" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12168" /db_xref="UniProtKB/Swiss-Prot:P96699" /translation="MPYQINIANIKINGVTQNGNIDVGPTVHNSHTANSKYFGANFSL GDLSPTSSLLNTGNIDSDVSDQDQIGNPSAPISNQI*" /label="ydgA CDS" gene complement(563242..563484) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /label="ydgA gene" CDS complement(563498..563770) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388438.1" /db_xref="EnsemblGenomes-Gn:BSU05570" /db_xref="EnsemblGenomes-Tr:CAB12364" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12169" /db_xref="UniProtKB/Swiss-Prot:P96700" /translation="MPSTVINLYYLKINSISGNGSITIGEAAYNSPTNNQKSQGTNSS FGDTSPTESVMENFLNDPDVNDQTSIGNSDTSNVNAPPIAPPPILD*" /label="ydgB CDS" gene complement(563498..563770) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /label="ydgB gene" promotor_-10 complement(563792..563811) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(563796) /Source="Nicolas_upshifts" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(563825..563834) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 563989..563996 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 564012..564031 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 564020 /Source="Nicolas_upshifts" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="upshifts" CDS 564069..564656 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388439.1" /db_xref="EnsemblGenomes-Gn:BSU05580" /db_xref="EnsemblGenomes-Tr:CAB12365" /db_xref="GOA:P96701" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12170" /db_xref="UniProtKB/Swiss-Prot:P96701" /translation="MKSKGVESRKRLLKAAANEFSVRGFHDAKVSEIVKKAGFTQPSF YLYFQSKEAIFAELITDFHSRVRKLTESLLLENGLNTEDVSKRVLLAVETVFQFLDED KDLTKIGFFLNPEAKQMKKDLAMVLKENLEAEQRLGYFHSELDMETVAECLVGMIEHL TESFLLTGIKDPASLAAEVVNLLIYGMLPKGNDVR*" /label="ydgC CDS" gene 564069..564656 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /label="ydgC gene" CDS 564653..564997 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388440.1" /db_xref="EnsemblGenomes-Gn:BSU05590" /db_xref="EnsemblGenomes-Tr:CAB12366" /db_xref="GOA:P96702" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12171" /db_xref="UniProtKB/Swiss-Prot:P96702" /translation="MISIMMKVSLAVFMLAGGIIKVSRVPFQVEHWRHYQYPLWFLTV TGILEIAGALAMTAGIWNRYAAIGAGVLFVVLMAGAIHAHMFRARQSVIMAIQAMICL IVSIMIIMGSYT*" /label="ydgD CDS" gene 564653..564997 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /label="ydgD gene" S_feature 564998..565159 /Source="Nicolas_S_feature" /locus_tag="new_603941_604102" /HighExp="Salt, Diami, dia15, dia5, aero, H2O2, SMMPr, Etha, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S196" CDS 565160..565633 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388441.1" /db_xref="EnsemblGenomes-Gn:BSU05600" /db_xref="EnsemblGenomes-Tr:CAB12367" /db_xref="GOA:P96703" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12172" /db_xref="UniProtKB/Swiss-Prot:P96703" /translation="MAFTLEDMTEEEFEAFRGMSVQNFAKQNITSGTWTEKEAFEKSE QAYENMIPNGRDSSNHYFWNITNDQGERMGWLWLYADPLHPQKEAFIYSFGLYEAFRG KGLAQLALQTLDERARELGAERLALHVFAHNETAVYLYQKMGYAMTNIRMRKQLC*" /label="ydgE CDS" gene 565160..565633 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /label="ydgE gene" S_feature 565634..566326 /Source="Nicolas_S_feature" /locus_tag="new_604577_605269" /HighExp="Salt, H2O2, dia15, aero, T-2.40H, Diami, T-3.40H, T-1.40H, T-4.40H, T-0.40H" /AntisenseName="vmlR" /AntisenseCor="-7.1224465259194999E-2" /AntisenseRegPval="-0.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S197" downshifts complement(565776) /Source="Nicolas_upshifts" /id="D267" /incds=0 /nref=4 /ntot=88 /MaxReadThrough="0.39199" /MaxDrop="3.39645" /score="18.2783449" /energy="-8.8" /TU="NA" /idTUdmin="U436" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(565793..567436) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16109936, 22226636, 24687494, 25891423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16109936, 22226636, 24687494, 25891423; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding cassette efflux transporter" /protein_id="NP_388442.1" /db_xref="EnsemblGenomes-Gn:BSU05610" /db_xref="EnsemblGenomes-Tr:CAB12368" /db_xref="GOA:P39115" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG10767" /db_xref="UniProtKB/Swiss-Prot:P39115" /translation="MKEIVTLTNVSYEVKDQTVFKHVNASVQQGDIIGIIGKNGAGKS TLLHLIHNDLAPAQGQILRKDIKLALVEQETAAYSFADQTPAEKKLLEKWHVPLRDFH QLSGGEKLKARLAKGLSEDADLLLLDEPTNHLDEKSLQFLIQQLKHYNGTVILVSHDR YFLDEAATKIWSLEDQTLIEFKGNYSGYMKFREKKRLTQQREYEKQQKMVERIEAQMN GLASWSEKAHAQSTKKEGFKEYHRVKAKRTDAQIKSKQKRLEKELEKAKAEPVTPEYT VRFSIDTTHKTGKRFLEVQNVTKAFGERTLFKNANFTIQHGEKVAIIGPNGSGKTTLL NIILGQETAEGSVWVSPSANIGYLTQEVFDLPLEQTPEELFENETFKARGHVQNLMRH LGFTAAQWTEPIKHMSMGERVKIKLMAYILEEKDVLILDEPTNHLDLPSREQLEETLS QYSGTLLAVSHDRYFLEKTTNSKLVISNNGIEKQLNDVPSERNEREELRLKLETERQE VLGKLSFMTPNDKGYKELDQAFNELTKRIKELDHQDKKD*" /label="vmlR CDS" gene complement(565793..567436) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /label="vmlR gene" S_feature complement(567471..567668) /Source="Nicolas_S_feature" /locus_tag="new_606414_606611_c" /HighExp="BC, Sw, B60, B36, LoTm, S7, HiOs, S4, BI, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S198" promotor_-35 567485..567487 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 567504..567522 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 567508 /Source="Nicolas_upshifts" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(567514) /Source="Nicolas_upshifts" /id="D268" /incds=0 /nref=210 /ntot=265 /MaxReadThrough="3.59768" /MaxDrop="6.27457" /score="29.5863709" /energy="-11.8" /TU="U436" /idTUdmin="U437" /TUdmin=242 /isTUend="FALSE" /label="downshifts" downshifts 567634 /Source="Nicolas_upshifts" /id="D269" /incds=0 /nref=35 /ntot=150 /MaxReadThrough="1.71902" /MaxDrop="4.95368" /score="-7.23582918" /energy="-13.3" /TU="NA" /idTUdmin="U435" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(567660..567679) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(567672) /Source="Nicolas_upshifts" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(567692..567699) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(567755) /Source="Nicolas_upshifts" /id="D270" /incds=0 /nref=92 /ntot=203 /MaxReadThrough="2.22553" /MaxDrop="5.71399" /score="18.9878298" /energy="-13.3" /TU="NA" /idTUdmin="U437" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(567756..569132) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16109936, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388443.1" /db_xref="EnsemblGenomes-Gn:BSU05620" /db_xref="EnsemblGenomes-Tr:CAB12369" /db_xref="GOA:P96704" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12173" /db_xref="UniProtKB/Swiss-Prot:P96704" /translation="MTDDMTKDNINQQTLQRGLKNRHIQLIAIGGAIGTGLFLGSGKS IHFAGPSILFAYMITGIICFLIMRSLGELLLSNLNYHSFVDFVQDYLGDMAAFITGWT YWFCWISIAMADLTAVGLYTQYWLPGVPQWVPGLIALIILLIMNLATVKLFGELEFWF ALIKVIAILALIVIGLVMIFKGFSTSSGVSSFTNLWSHGGLFPNGMHGFILSFQMVVF AFVGIELVGLTAGETENPEKVIPKAINNIPVRVLLFYIGALLVIMSIYPWDIINPSES PFVQVFVAVGIVGAASIINFVVLTSAASACNSAVFSTSRMVYSLAKDHNAPESMAKLT QRKVPRNALFFSAIVILIGVTLNYIMPEGVFTLITSISTVCFIYIWGITVICHMKYRK TRPELAKTNKFKLPLYPFTNYLILAFLAFVLVVLALAQDTRVSLFVTPVWFILLIVIY KVRKAKHQ*" /label="ydgF CDS" gene complement(567756..569132) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /label="ydgF gene" misc_feature complement(569182..569201) /Source="Nicolas_upshift_promotors" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(569197) /Source="Nicolas_upshifts" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="upshifts" Polymorphism join(569271,569273) /Source="geneious" /ID="SNP_BsDelta6_608215_608214" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(A)5 -> (A)6" /Codon_Change /Coverage=41 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="A" /Variant_P_Value="8.2e-115" /Variant_Raw_Frequency=39 /comment="dinB_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" terminator 569272..569305 /created_by="User" /comment="dinB_terminator_improvement" /modified_by="User" /label="Delta6_dinB_Terminator" CDS complement(569304..569822) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1847907, 3110138, 12644484, 16267290, 22059487; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nuclease inhibitor" /protein_id="NP_388444.1" /db_xref="EnsemblGenomes-Gn:BSU05630" /db_xref="EnsemblGenomes-Tr:CAB12370" /db_xref="GOA:Q02886" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG10539" /db_xref="UniProtKB/Swiss-Prot:Q02886" /translation="MSDFAFKLYEYNVWANQQIFNRLKELPKEIYHQEIQSVFPSISH VLSHVYLSDLGWIEVFSGKTLSDALALAEQLKEQTEAKEIEEMEDLFLRLSERYILFL QQKEQLNKPLQIQNPSSGIMKTTVSELLPHVVNHGTYHRGNITAMLRQAGYASAPTDY GLYLFMTKTEKA*" /label="dinB CDS" gene complement(569304..569822) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /label="dinB gene" downshifts complement(569318) /Source="Nicolas_upshifts" /id="D271" /incds=0 /nref=35 /ntot=176 /MaxReadThrough="2.77148" /MaxDrop="6.32316" /score="16.2748201" /energy="-15" /TU="NA" /idTUdmin="U438" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(569848..569867) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(569867) /Source="Nicolas_upshifts" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(569883..569886) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 569904..569911 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 569926..569945 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 569944 /Source="Nicolas_upshifts" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="upshifts" CDS complement(569956..570357) /gene="ydhUc" /locus_tag="PG10_BSU_05890_3'_ext" /locus_tag="BSU_05890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; C-terminal part of YhdU" /db_xref="SubtiList:BG12198" /modified_by="User" /translation="FFQSSNFRGKQKQYRDLLRGIFLEEIAHVELVQNTINALLDESG GEGVGSQGTDQAPLDEAVKHANPHHYIIGAQSSLPVDAGGNPWNGSWVYNHGNLITDL LDNLLLESTGVLQKTRIYEMSSNQTHYSLPR*" /label="PG10_BSU_05890_3'_ext" CDS complement(569956..570084) /locus_tag="PG10_rand_002" /created_by="User" /transl_table=11 /pseudo /translation="MYNHGNLITDLLDNLLLESTGVLQKTRIYEMSSNQTHYSLPR*" /label="PG10_rand_002" gene complement(569956..570357) /gene="ydhUc" /locus_tag="PG10_BSU_05890_3'_ext" /old_locus_tag="BSU_05890" /pseudo /modified_by="User" /label="PG10_BSU_05890_3'_ext" gene complement(569956..570084) /locus_tag="PG10_rand_002" /created_by="User" /label="PG10_rand_002" CDS 569974..570066 /locus_tag="PG10_rand_001" /created_by="User" /transl_table=11 /pseudo /translation="MRLIRAHFINSCFLQHTCRLKKQVIQQVSN*" /label="PG10_rand_001" gene 569974..570066 /locus_tag="PG10_rand_001" /created_by="User" /modified_by="User" /label="PG10_rand_001" SCAR 569976..569977 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs22" CDS complement(570288..570482) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; N-terminal part of YhdU" /translation="MYYYKEELINIIKPDKPDPAAAKVLQEILGGHYGEMRTMMQFFS KALISEESRNSTAICFAAFF*" /label="ydhUn CDS" gene complement(570288..570482) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /pseudo /label="ydhUn gene" promotor_-10 complement(570515..570526) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(570523) /Source="Nicolas_upshifts" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(570540..570546) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 570601..570608 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 570622..570641 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box 570624..570724 /Source="Nicolas_upshift_promotors" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 570626 /Source="Nicolas_upshifts" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(570672) /Source="Nicolas_upshifts" /id="D286" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="2.24619" /MaxDrop="4.20389" /score="11.9939391" /energy="-9" /TU="NA" /idTUdmin="U456" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" upshifts 570684 /Source="Nicolas_upshifts" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 570692..570699 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 570713..570732 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 570728..570815 /Source="Nicolas_S_feature" /locus_tag="new_635022_635109" /HighExp="LBGstat, C30, Cold, Heat, Oxctl, T-1.10H, T-0.40H, T-1.40H, UNK1, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.96, 0.0919, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S204" upshifts 570728 /Source="Nicolas_upshifts" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" tRNA 570816..570892 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Arg tRNA" gene 570816..570892 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /label="trnE-Arg gene" tRNA 570906..570979 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(UCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Gly tRNA" gene 570906..570979 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /label="trnE-Gly gene" rRNA 571139..572693 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-16S rRNA" gene 571139..572693 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /label="rrnE-16S gene" rRNA 572861..575788 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-23S rRNA" gene 572861..575788 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /label="rrnE-23S gene" rRNA 575844..575960 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-5S rRNA" gene 575844..575960 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /label="rrnE-5S gene" tRNA 575974..576050 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Met tRNA" gene 575974..576050 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /label="trnE-Met gene" tRNA 576111..576187 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Asp tRNA" gene 576111..576187 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /label="trnE-Asp gene" downshifts 576184 /Source="Nicolas_upshifts" /id="D287" /incds=0 /nref=38 /ntot=211 /MaxReadThrough="6.00554" /MaxDrop="5.14761" /score="7.63230089" /energy="-5.4" /TU="NA" /idTUdmin="U460" /TUdmin="-3784" /isTUend="FALSE" /label="downshifts" promotor_-35 576288..576292 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 576308..576327 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 576312 /Source="Nicolas_upshifts" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="upshifts" CDS 576368..577345 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /EC_number="2.7.4.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-monophosphate kinase" /protein_id="NP_388471.1" /db_xref="EnsemblGenomes-Gn:BSU05900" /db_xref="EnsemblGenomes-Tr:CAB12409" /db_xref="GOA:O05514" /db_xref="InterPro:IPR006283" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10693" /db_xref="UniProtKB/Swiss-Prot:O05514" /translation="MDEFDLIHSITPRTIHHSSVDVGIGDDAALYTAKHGVQEIVCVD TMVEDVHFKLHYSSPEDIGYKALAVNISDIAAMGGIPKFYLVSLAVPSKWTESEIKAM YEGMNELAKLYHMDLIGGDTVSTADKLVVTVTVIGEIEKGQACLRSLAKPNDIVFVTG EIGSSAAGLSLLLEETNPQNSSVETDYFIHRHKRPEPRVSVGRLCSIFKRAALNDVSD GLASELNEIAEASCVSIEIVESMLPIHSDLPKLHPNWKEWALFGGEDFELTGTVSNEE WEVLKQECAALHLPITKIGYVREKTKSKVILKTDQTSMILEKKGYNHFK*" /label="thiL CDS" gene 576368..577345 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /label="thiL gene" CDS 577360..577836 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; ADP binding protein" /protein_id="NP_388472.1" /db_xref="EnsemblGenomes-Gn:BSU05910" /db_xref="EnsemblGenomes-Tr:CAB12410" /db_xref="GOA:O05515" /db_xref="InterPro:IPR003442" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12199" /db_xref="UniProtKB/Swiss-Prot:O05515" /translation="MKQLKWRTVNPEETKAIAKLTAAFAKPGDVLTLEGDLGAGKTTF TKGFAEGLGITRIVNSPTFTIIKEYNDGVLPLYHMDVYRMEDESEDLGLDEYFHGQGV CLVEWAHLIEEQLPQERLQIVIKRAGDDEREITFTAVGNRYEMLCEELSRHDNISN*" /label="tsaE CDS" gene 577360..577836 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /label="tsaE gene" CDS 577817..578506 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; protease involved in TsaD function" /protein_id="NP_388473.1" /db_xref="EnsemblGenomes-Gn:BSU05920" /db_xref="EnsemblGenomes-Tr:CAB12411" /db_xref="GOA:O05516" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR022496" /db_xref="SubtiList:BG12200" /db_xref="UniProtKB/Swiss-Prot:O05516" /translation="MTILAIDTSNYTLGIALLREDTVIAEYITYLKKNHSVRAMPAVH SLLNDCDMAPQDLSKIVVAKGPGSYTGVRIGVTLAKTLAWSLDIPISAVSSLETLAAN GRHFDGLISPIFDARRGQVYTGLYQYKNGLLEQVVPDQNVMLADWLEMLKEKDRPVLF LGHDTSLHKQMIEDVLGTKGFIGTAAQHNPRPSELAFLGKEKEAADVHGLVPDYLRLA EAEAKWIESQK*" /label="tsaB CDS" gene 577817..578506 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /label="tsaB gene" CDS 578516..578971 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /EC_number="2.3.1.267" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2828880; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein S18 alanine N-acetyltransferase" /protein_id="NP_388474.1" /db_xref="EnsemblGenomes-Gn:BSU05930" /db_xref="EnsemblGenomes-Tr:CAB12412" /db_xref="GOA:O05517" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR006464" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12201" /db_xref="UniProtKB/Swiss-Prot:O05517" /translation="MKTKAAVRNMRLEDIDHVYEIEASSFTSPWTKDSFYHELLENPY AHYLVIEKDGHLAGYCGIWIVMDDAQITNIAIKPEYRGQSLGETLFRSAVELCKEKDA RRLSLEVRVSNHPAQGLYKKFGMQPGGIRKNYYTDNGEDALIMWVTINE*" /label="rimI CDS" gene 578516..578971 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /label="rimI gene" CDS 578964..580004 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11073929, 12682299, 9743119, 20824107, 21625506, 21873492, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; glycation binding protein" /protein_id="NP_388475.1" /db_xref="EnsemblGenomes-Gn:BSU05940" /db_xref="EnsemblGenomes-Tr:CAB12413" /db_xref="GOA:O05518" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR017860" /db_xref="InterPro:IPR017861" /db_xref="InterPro:IPR022450" /db_xref="SubtiList:BG12202" /db_xref="UniProtKB/Swiss-Prot:O05518" /translation="MSEQKDMYVLGIETSCDETAAAIVKNGKEIISNVVASQIESHKR FGGVVPEIASRHHVEQITLVIEEAFRKAGMTYSDIDAIAVTEGPGLVGALLIGVNAAK ALSFAYNIPLVGVHHIAGHIYANRLVEDIVFPALALVVSGGHTELVYMKEHGSFEVIG ETLDDAAGEAYDKVARTMGLPYPGGPQIDKLAEKGNDNIPLPRAWLEEGSYNFSFSGL KSAVINTLHNASQKGQEIAPEDLSASFQNSVIDVLVTKTARAAKEYDVKQVLLAGGVA ANRGLRAALEKEFAQHEGITLVIPPLALCTDNAAMIAAAGTIAFEKGIRGAYDMNGQP GLELTSYQSLTR*" /label="tsaD CDS" gene 578964..580004 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /label="tsaD gene" downshifts 579968 /Source="Nicolas_upshifts" /id="D288" /incds=0 /nref=39 /ntot=222 /MaxReadThrough="3.15518" /MaxDrop="4.65228" /score="3.97936019" /energy="-10.1" /TU="NA" /idTUdmin="U460" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(580234..582162) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11916677, 16109936, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388476.2" /db_xref="EnsemblGenomes-Gn:BSU05950" /db_xref="EnsemblGenomes-Tr:CAB12414" /db_xref="GOA:O05519" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12203" /db_xref="UniProtKB/Swiss-Prot:O05519" /translation="MMILQVNQLSKSFGADTILNNIKLEVRNRDRIAIVGRNGAGKST LLKIIAGQLSYEKGEIIKPKDITMGYLAQHTGLDSKLTIKEELLTVFDHLKAMEKEMR AMEEKMAAADPGELESIMKTYDRLQQEFKDKGGYQYEADVRSVLHGLGFSHFDDSTQV QSLSGGQKTRLALGKLLLTQPDLLILDEPTNHLDIDTLTWLEHYLQGYSGAILIVSHD RYFLDKVVNQVYEVSRAESKKYHGNYSAYLDQKAAQYEKDLKMYEKQQDEIAKLQDFV DRNLARASTTKRAQSRRKQLERMDVMSKPLGDEKSANFHFDITKQSGNEVLRVQDLTI SYENQPPLLTEVSFMLTRGESAALVGPNGIGKSTLLKTLIDTLKPDQGTISYGSNVSV GYYDQEQAELTSSKRVLDELWDEYPGLPEKEIRTCLGNFLFSGDDVLKPVHSLSGGEK ARLALAKLMLQKANFLILDEPTNHLDLDSKEVLENALIDYPGTLLFVSHDRYFINRIA TRVLELSSSHIEEYLGDYDYYTEKKTEQLELEKMNQQEETDKTPATVKSDSKRSYEEE KEWKKKERQRLRRIEEIETTVQTIEENISRNDELLCDPEVYQDHEKVQAIHADNEKLN QELESLLSEWEELSTEED*" /label="ydiF CDS" gene complement(580234..582162) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /label="ydiF gene" downshifts complement(580251) /Source="Nicolas_upshifts" /id="D289" /incds=0 /nref=170 /ntot=266 /MaxReadThrough="1.32926" /MaxDrop="5.81869" /score="16.702581" /energy="-12.6" /TU="NA" /idTUdmin="U463" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" misc_feature 581914..581933 /Source="Nicolas_upshift_promotors" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 581924 /Source="Nicolas_upshifts" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" S_feature 581926..582115 /Source="Nicolas_S_feature" /locus_tag="new_646220_646409" /HighExp="Diami, H2O2, dia5, Paraq, G135, G180, G150, Cold, dia15, BC" /AntisenseName="ydiF" /AntisenseCor="0.47406689574609401" /AntisenseRegPval="-15.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S205" promotor_-35 582080..582087 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 582101..582120 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 582117..582287 /Source="Nicolas_S_feature" /locus_tag="new_646411_646581" /HighExp="Diami, dia5, dia15, H2O2, Etha, G180, G150, Oxctl, Mt0, Paraq" /AntisenseName="ydiF" /AntisenseCor="0.63697451027099605" /AntisenseRegPval="-31.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S206" upshifts 582117 /Source="Nicolas_upshifts" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(582182..582201) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(582194) /Source="Nicolas_upshifts" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(582215..582222) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 582288..582800 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /EC_number="4.6.1.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10903949, 16632608, 18607082, 20606263, 25941396, 26575208; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdenum cofactor biosynthesis protein C" /protein_id="NP_388477.1" /db_xref="EnsemblGenomes-Gn:BSU05960" /db_xref="EnsemblGenomes-Tr:CAB12415" /db_xref="GOA:O05520" /db_xref="InterPro:IPR002820" /db_xref="InterPro:IPR023045" /db_xref="InterPro:IPR036522" /db_xref="SubtiList:BG12204" /db_xref="UniProtKB/Swiss-Prot:O05520" /translation="MNGFSHFNEQGRAQMVDISEKSSTVRTAAAVSSVHMKNEVYEKI QSHDIGKGDVLAVAQVAGIMAAKQTSNIIPMCHPLSLSGVDISFDWKIKEAEVILHIK AQVKTKGSTGVEMEALTSASVCALTVYDMCKALDKGMVIGPTFLLEKTGGKNGDFKRE LSEYNLEDQK*" /label="moaC CDS" gene 582288..582800 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /label="moaC gene" CDS 582797..583444 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription repressor of cydABCD and yjlC-ndh expression" /protein_id="NP_388478.1" /db_xref="EnsemblGenomes-Gn:BSU05970" /db_xref="EnsemblGenomes-Tr:CAB12416" /db_xref="GOA:O05521" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR009718" /db_xref="InterPro:IPR022876" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2VT2" /db_xref="PDB:2VT3" /db_xref="SubtiList:BG12205" /db_xref="UniProtKB/Swiss-Prot:O05521" /translation="MNKDQSKIPQATAKRLPLYYRFLKNLHASGKQRVSSAELSDAVK VDSATIRRDFSYFGALGKKGYGYNVDYLLSFFRKTLDQDEMTDVILIGVGNLGTAFLH YNFTKNNNTKISMAFDINESKIGTEVGGVPVYNLDDLEQHVKDESVAILTVPAVAAQS ITDRLVALGIKGILNFTPARLNVPEHIRIHHIDLAVELQSLVYFLKHYSVLEEIE*" /label="rex CDS" gene 582797..583444 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /label="rex gene" promotor_no_box 583274..583374 /Source="Nicolas_upshift_promotors" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 583334 /Source="Nicolas_upshifts" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" CDS 583466..583639 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388479.1" /db_xref="EnsemblGenomes-Gn:BSU05980" /db_xref="EnsemblGenomes-Tr:CAB12417" /db_xref="GOA:O05522" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG12206" /db_xref="UniProtKB/Swiss-Prot:O05522" /translation="MPIGPGSLAVIAIVALIIFGPKKLPELGKAAGDTLREFKNATKG LTSDEEEKKKEDQ*" /label="tatAY CDS" gene 583466..583639 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /label="tatAY gene" CDS 583646..584410 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11007775, 15187182, 15849754, 16850406, 19049517, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007775, 15187182, 15849754, 16850406, 19049517, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388480.1" /db_xref="EnsemblGenomes-Gn:BSU05990" /db_xref="EnsemblGenomes-Tr:CAB12418" /db_xref="GOA:O05523" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG12207" /db_xref="UniProtKB/Swiss-Prot:O05523" /translation="MTRMKVNQMSLLEHIAELRKRLLIVALAFVVFFIAGFFLAKPII VYLQETDEAKQLTLNAFNLTDPLYVFMQFAFIIGIVLTSPVILYQLWAFVSPGLYEKE RKVTLSYIPVSILLFLAGLSFSYYILFPFVVDFMKRISQDLNVNQVIGINEYFHFLLQ LTIPFGLLFQMPVILMFLTRLGIVTPMFLAKIRKYAYFTLLVIAALITPPELLSHMMV TVPLLILYEISILISKAAYRKAQKSSAADRDVSSGQ*" /label="tatCY CDS" gene 583646..584410 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /label="tatCY gene" downshifts 584390 /Source="Nicolas_upshifts" /id="D290" /incds=0 /nref=151 /ntot=251 /MaxReadThrough="4.01237" /MaxDrop="6.80817" /score="19.4098216" /energy="-12.7" /TU="NA" /idTUdmin="U461" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(584448..584639) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388481.1" /db_xref="EnsemblGenomes-Gn:BSU06000" /db_xref="EnsemblGenomes-Tr:CAB12419" /db_xref="GOA:O05524" /db_xref="InterPro:IPR025426" /db_xref="SubtiList:BG12208" /db_xref="UniProtKB/Swiss-Prot:O05524" /translation="MRNPVVWGMIYFAVGCIFTYLAASSPGSMWSFYSILLMVFAAYN ISISFKMFAFSFKIKKNQK*" /label="ydiK CDS" gene complement(584448..584639) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /label="ydiK gene" downshifts complement(584465) /Source="Nicolas_upshifts" /id="D291" /incds=0 /nref=211 /ntot=258 /MaxReadThrough="0.81338" /MaxDrop="6.43897" /score="25.5376889" /energy="-12.7" /TU="NA" /idTUdmin="U467" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(584636..585370) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /EC_number="3.4.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_388482.1" /db_xref="EnsemblGenomes-Gn:BSU06010" /db_xref="EnsemblGenomes-Tr:CAB12420" /db_xref="GOA:O05525" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG12209" /db_xref="UniProtKB/Swiss-Prot:O05525" /translation="MRKQYWFIILTYIIMQFSALIAIPLLFKFGYAGGQPTDENMLHA QGLWSVISFIACLVVVLLILRTVPKETLRNGQKDSIGLSILWAIAGFFIALFSQGIAG SIEYYVFGIGRESENTQAILDVIQAVPLMIIVSSIVGPILEEIIFRKIIFGALYEKTN FFFAGLISSVIFGIVHADLKHLLLYTAMGFTFAFLYARTKRIWVPIFAHLMMNTFVVI MQLEPVRNYLEQQSTQMQLIIGGLFL*" /label="ydiL CDS" gene complement(584636..585370) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /label="ydiL gene" promotor_-35 585028..585033 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 585048..585066 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 585050 /Source="Nicolas_upshifts" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 585369..585370 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-35" promotor_-10 585380..585394 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-10" upshifts 585402 /Source="Nicolas_upshifts" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="upshifts" promotor_-10 complement(585407..585426) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 585424..585532 /Source="Nicolas_S_feature" /locus_tag="new_649718_649826" /HighExp="S4, S5, H2O2, S3, S8, S6, Diami, Oxctl, G180, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.238" /TUlongSig="NA" /TUlongPSig="NA" /label="S207" upshifts complement(585427) /Source="Nicolas_upshifts" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(585440..585445) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 585506..585512 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 585526..585545 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 585534..585608 /Source="Nicolas_S_feature" /locus_tag="new_649828_649902" /HighExp="HiTm, Etha, dia15, Heat, C90, dia5, LoTm, Lbexp, H2O2, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S208" upshifts 585534 /Source="Nicolas_upshifts" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="upshifts" CDS 585609..585893 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11407116, 17031040, 9303302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11407116, 17031040, 9303302; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin small subunit" /protein_id="NP_388483.2" /db_xref="EnsemblGenomes-Gn:BSU06020" /db_xref="EnsemblGenomes-Tr:CAB12421" /db_xref="GOA:P28599" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR018369" /db_xref="InterPro:IPR020818" /db_xref="InterPro:IPR037124" /db_xref="SubtiList:BG10422" /db_xref="UniProtKB/Swiss-Prot:P28599" /translation="MLKPLGDRVVIELVESEEKTASGIVLPDSAKEKPQEGKIVAAGS GRVLESGERVALEVKEGDRIIFSKYAGTEVKYEGTEYLILRESDILAVIG*" /label="groES CDS" gene 585609..585893 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /label="groES gene" CDS 585940..587574 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9303302, 11407116, 17031040, 17420574, 22268681" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 11407116, 17031040, 17420574, 22268681; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin large subunit" /protein_id="NP_388484.1" /db_xref="EnsemblGenomes-Gn:BSU06030" /db_xref="EnsemblGenomes-Tr:CAB12422" /db_xref="GOA:P28598" /db_xref="InterPro:IPR001844" /db_xref="InterPro:IPR002423" /db_xref="InterPro:IPR018370" /db_xref="InterPro:IPR027409" /db_xref="InterPro:IPR027410" /db_xref="InterPro:IPR027413" /db_xref="SubtiList:BG10423" /db_xref="UniProtKB/Swiss-Prot:P28598" /translation="MAKEIKFSEEARRAMLRGVDALADAVKVTLGPKGRNVVLEKKFG SPLITNDGVTIAKEIELEDAFENMGAKLVAEVASKTNDVAGDGTTTATVLAQAMIREG LKNVTAGANPVGVRKGMEQAVAVAIENLKEISKPIEGKESIAQVAAISAADEEVGSLI AEAMERVGNDGVITIEESKGFTTELEVVEGMQFDRGYASPYMVTDSDKMEAVLDNPYI LITDKKITNIQEILPVLEQVVQQGKPLLLIAEDVEGEALATLVVNKLRGTFNAVAVKA PGFGDRRKAMLEDIAVLTGGEVITEDLGLDLKSTQIAQLGRASKVVVTKENTTIVEGA GETDKISARVTQIRAQVEETTSEFDREKLQERLAKLAGGVAVIKVGAATETELKERKL RIEDALNSTRAAVEEGIVSGGGTALVNVYNKVAAVEAEGDAQTGINIVLRALEEPIRQ IAHNAGLEGSVIVERLKNEEIGVGFNAATGEWVNMIEKGIVDPTKVTRSALQNAASVA AMFLTTEAVVADKPEENGGGAGMPDMGGMGGMGGMM*" /label="groEL CDS" gene 585940..587574 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /label="groEL gene" S_feature 587575..587667 /Source="Nicolas_S_feature" /locus_tag="new_651869_651961" /HighExp="HiTm, Etha, dia15, Heat, Diami, dia5, C90, S1, S2, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S209" downshifts 587624 /Source="Nicolas_upshifts" /id="D292" /incds=0 /nref=228 /ntot=267 /MaxReadThrough="6.24882" /MaxDrop="5.77437" /score="-6.71161833" /energy="-16.3" /TU="U468" /idTUdmin="U466" /TUdmin=2112 /isTUend="FALSE" /label="downshifts" CDS complement(587662..587790) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); C-terminal part of YdzT; defective prophage 3" /translation="EAGVGIKEIQQQFGHSDINTTMDIYAHMTANMEKRSPNSLVN*" /label="ydzTc CDS" gene complement(587662..587790) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /pseudo /label="ydzTc gene" S_feature 587669..>588895 /Source="Nicolas_S_feature" /locus_tag="new_651963_653431" /HighExp="H2O2, Heat, dia15, Diami, S1, G135, G150, S2, G180, dia5" /AntisenseName="ydzT" /AntisenseCor="-2.9485116084752801E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="0.23100000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S210" CDS complement(587793..587951) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52563.1" /translation="MIYQDSSFIFEREDGHPQLRKVIETRLKRLLKKAGIKRMSPPTL LGIPIPPY*" /label="ydzT CDS" gene complement(587793..587951) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /pseudo /label="ydzT gene" CDS complement(587996..588124) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52564.1" /translation="MISQVTKTLYTPNNQIEKYQLLTPKTTGSVDIVRIDETMSIY*" /label="ydzT CDS" gene complement(587996..588124) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /pseudo /label="ydzT gene" CDS complement(588217..588426) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52565.1" /translation="MYEDRTLELNEQYSHNCLGGIHACGRMIFRKAKTQGIIKMNPTG DFQLPKKQQSIGKRGADTFSKARSI*" /label="ydzT CDS" gene complement(588217..588426) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /pseudo /label="ydzT gene" CDS complement(588419..588724) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); N-terminal part of YdzT; defective prophage 3" /db_xref="PSEUDO:CAX52566.1" /translation="MELSYLLGIDPLTKKRLEISKGRFKTKKEAPVAARHVELQNDNG TFIKESDMPFKTFAKGWLKIYNRSGVKISSVRASEKKMMHFIAVLGQYPISKTQKNV* " /label="ydzTn CDS" gene complement(588419..588724) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /pseudo /label="ydzTn gene" SCAR join(588895,588902) /created_by="AR/SM" /note="deletion occured in betwen marked nucleotides" /label="Delta6_1" N_region 588896..588901 /note="KpnI site (GGTACC)" /created_by="User" /label="Delta6_1" CDS complement(589000..591489) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11118449, 11390381, 12897001" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11118449, 11390381, 12897001; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the glucitol operon" /protein_id="NP_388495.1" /db_xref="EnsemblGenomes-Gn:BSU06140" /db_xref="EnsemblGenomes-Tr:CAB12433" /db_xref="GOA:P39143" /db_xref="InterPro:IPR002182" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR024123" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10178" /db_xref="UniProtKB/Swiss-Prot:P39143" /translation="MAELENRKQFAQMLAPGVKTLKLHPDYKVRRKKNEKTGQSYIDK IALQLGVSPNTIKSWIGQMGANYIPGRIDDGKLFGMIWIILEKTDLDIEWLTDLLEAT TIPVIKPALPVWAASCLKKAKILRKDGLFGAPSEGEIENVVKRLFHDRPGQETNALTE QPITHNLPSRWSGRFIGRSFDMEAIRQWMLSPSPVCLITGWAGMGKTTIALEAAYSCV DDTSVWPAFNSIIWVSADWKGLSFSDFLNTIAYQLGRKEQIDKSINVKRFVVRNALAN YTREKPILLIVDSIDTAERDIHEFITSLPQGVKVLLTARENVKQTYRESFGEMTAIQL SGLDQTDAHEFFQQEVHHCLQTCNLPRKREKLEQLLHLSSDLKNEFISATAGNPKAMA LSIAYMSDDDIPAQQLIHELGKAGYSLLELFEFLFGRTWDRCNEDTRKLWQTLCFFSK PPDEKSLAAAAGLDARRFHYAMEQMRSYALIQPERSQGRTQYLAHQTVVAYGEQHLSE QHEYEKEARNRWAHYYIDYAETHLKREQPNSIYWSYLLGRNLDQMKQEWPNILKVIQW ASETEQKEILIELITRISHFLSRINLPLRIEYGRKAADAAHHLGQHTREAYFRIDTSG WALMEVNDLDGALQQIEAGLKILEQSDAHDAYDLKVWGHALKARLFLKDGQQEKAETI LNEIENQPISPTIQHRVLLVRGDLSFARGYHVEAIQLYEAANEISSTYGGEKTIEAYF NLGVAYVKCDQFEKAEEAFEQMLYDKHNANQVELIYYHYGMAQLLYRKGEKTKAVESN QKAIRLIDSWEPAIGIRGEVERLARATKENE*" /label="gutR CDS" gene complement(589000..591489) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /label="gutR gene" downshifts complement(589022) /Source="Nicolas_upshifts" /id="D298" /incds=0 /nref=56 /ntot=209 /MaxReadThrough="0.69715" /MaxDrop="4.256" /score="0.285109352" /energy="-13.9" /TU="NA" /idTUdmin="U474" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(591503..591522) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(591529) /Source="Nicolas_upshifts" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(591536..591543) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 591592..591593 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 591608..591690 /Source="Nicolas_S_feature" /locus_tag="new_667383_667465" /HighExp="Lbstat, BI, M40t90, Mt0, M0t90, dia5, dia0, Lbexp, Lbtran, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.848" /TUlongSig="NA" /TUlongPSig="NA" /label="S220" upshifts 591608 /Source="Nicolas_upshifts" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 591609..591628 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 591691..592752 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /EC_number="1.1.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1460002, 8195086, 8195087, 12897001, 19784641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1460002, 8195086, 8195087, 12897001, 19784641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucitol (sorbitol) dehydrogenase" /protein_id="NP_388496.1" /db_xref="EnsemblGenomes-Gn:BSU06150" /db_xref="EnsemblGenomes-Tr:CAB12434" /db_xref="GOA:Q06004" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10177" /db_xref="UniProtKB/Swiss-Prot:Q06004" /translation="MTHTVPQNMKAAVMHNTREIKIETLPVPDINHDEVLIKVMAVGI CGSDLHYYTNGRIGNYVVEKPFILGHECAGEIAAVGSSVDQFKVGDRVAVEPGVTCGR CEACKEGRYNLCPDVQFLATPPVDGAFVQYIKMRQDFVFLIPDSLSYEEAALIEPFSV GIHAAARTKLQPGSTIAIMGMGPVGLMAVAAAKAFGAGTIIVTDLEPLRLEAAKKMGA THIINIREQDALEEIKTITNDRGVDVAWETAGNPAALQSALASVRRGGKLAIVGLPSQ NEIPLNVPFIADNEIDIYGIFRYANTYPKGIEFLASGIVDTKHLVTDQYSLEQTQDAM ERALQFKNECLKVMVYPNR*" /label="gutB CDS" gene 591691..592752 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /label="gutB gene" CDS 592826..594217 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897001, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+-glucitol symporter; prophage region 3" /protein_id="NP_388497.1" /db_xref="EnsemblGenomes-Gn:BSU06160" /db_xref="EnsemblGenomes-Tr:CAB12435" /db_xref="GOA:O34368" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12795" /db_xref="UniProtKB/Swiss-Prot:O34368" /translation="MIGTEKVTALKAKHQSKSSTGLSWFERIGYGFGDMSYNIIFQFV NAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDKTNTRWGKARPYLLWV AFPFALFTFLCFTTPHFGETGNMVYAYVTYILLGMSFSMQTIPVNSLTGRMTNSVEER TVLTTTRMILVYIGILLSISCATPLATAIGGEDQAFGFQMTALIYAAVSIVLNLFSFF TVRERIQPKKRKKQGIKKTLSVLFKNKPLLMLISSFLAFAIGFNIKLSTMVYYFTYNV NHKEFVFMGTVLFFGAALISNLFIPFFSEKWGRKQVMIITAALSLISYAGLHFTPYSS IPLIFIWLFASGFFTTPLNTLAWGMVADCVDYAEWKTGIRADGVVISSMSFINKLGVA LAGSFSAIYLGIAGYVANTDQTVASLNAIKNMNALIPGFFILLSIILIAFYPLTEKRY KHIISELEQRSAR*" /label="gutP CDS" gene 592826..594217 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /label="gutP gene" promotor_-35 594244..594251 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 594265..594284 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 594270 /Source="Nicolas_upshifts" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="upshifts" CDS 594312..595274 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26483775, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar kinase (ribokinase family); prophage region 3" /protein_id="NP_388498.1" /db_xref="EnsemblGenomes-Gn:BSU06170" /db_xref="EnsemblGenomes-Tr:CAB12436" /db_xref="GOA:O34768" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12796" /db_xref="UniProtKB/Swiss-Prot:O34768" /translation="MRSHSVVCIGELLIDFFCTDVDVDLMEGRQFLKSAGGAPANVSA AIAKLGGDAAFSGKVGKDPFGYFLKRTLDAVHVDTSMLVMDEKAPTTLAFVSLKQNGE RDFVFNRGADALFTLEDIDQEKLNEAKILHFGSATALLSDPFCSAYLRLMSIAKDNGQ FISFDPNYREDLWRGRVSEFVSVAKKAIAVSDFVKVSDEELEIISGVKDHEKGVAILH EIGANIVAVTLGKSGTLLSNGKDREIIPSIPVTSIDSTGAGDAFVGAALYQLANTDQI QSVDADFVKLREIVAFANKVGALVCTKIGAIDALPSLDEIGVSL*" /label="ydjE CDS" gene 594312..595274 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /label="ydjE gene" downshifts 595259 /Source="Nicolas_upshifts" /id="D299" /incds=0 /nref=86 /ntot=213 /MaxReadThrough="2.99546" /MaxDrop="4.52045" /score="16.4550614" /energy="-14" /TU="NA" /idTUdmin="U475" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 595399..595408 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 595415 /Source="Nicolas_upshifts" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 595421..595436 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 595470..596153 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11454200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11454200; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage shock protein A homolog regulator; prophage region 3" /protein_id="NP_388499.1" /db_xref="EnsemblGenomes-Gn:BSU06180" /db_xref="EnsemblGenomes-Tr:CAB12437" /db_xref="GOA:P54617" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG12797" /db_xref="UniProtKB/Swiss-Prot:P54617" /translation="MSIIGRFKDIMSANINALLDKAENPEKMVDQYLRNMNSDLAKVK AETAAVMAEEQRAKREYHECQADMEKMESYAMKALQAGNESDARKFLERKTSLESKLS ELQAANQIAATNAAQMRKMHDKLVSDIGELEARKNMIKAKWAVAKTQERMNKLGASVS STSQSMSAFGRMEDKVNKALDQANAMAELNSAPQDDMADLSAKYDTGGSSQVDDELAA LKAKMMLDK*" /label="pspA CDS" gene 595470..596153 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /label="pspA gene" S_feature 596154..596218 /Source="Nicolas_S_feature" /locus_tag="new_671929_671993" /HighExp="Salt, S0, aero, T-0.40H, T-1.40H, SMMPr, T-1.10H, T0.0H, Cold, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S221" CDS 596219..597244 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /function="16.5: Explore" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage replication protein; prophage region 3" /protein_id="NP_388500.1" /db_xref="EnsemblGenomes-Gn:BSU06190" /db_xref="EnsemblGenomes-Tr:CAB12438" /db_xref="GOA:O34434" /db_xref="InterPro:IPR013137" /db_xref="SubtiList:BG12798" /db_xref="UniProtKB/Swiss-Prot:O34434" /translation="MIISYKCPNCGSDMAFDSETGSLSCSSCGRQDNIESLPKENIAA RFSDDEAKEYQCKNCGAVLITEAETTATTCSFCGGAAILADRLSGHLAPAKVIPFTIS KQEAEQAFRKWCKKGLLTPRGFMSADRIKSITGMYIPFWMFDLNSEVQVRANCTRVHQ YEEGDYICTETEHFEAFRDINLDYLKIPVDASEKMKDELMDKLEPYSYEELKDFQTAY LAGYIAEKYNYTDEELFPRAKEKISSYIDSYIHSTFSGYTSVNVRDKHIHTKNVNSFY VLLPVWMVSYDYERAEHIFAMNGQTGKVVGKPPISRGKVAAWFSGIAGGTFLALKLVS LMMGGGF*" /label="ydjG CDS" gene 596219..597244 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /label="ydjG gene" CDS 597244..598008 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; prophage region 3" /protein_id="NP_388501.1" /db_xref="EnsemblGenomes-Gn:BSU06200" /db_xref="EnsemblGenomes-Tr:CAB12439" /db_xref="GOA:O35004" /db_xref="InterPro:IPR007621" /db_xref="SubtiList:BG12799" /db_xref="UniProtKB/Swiss-Prot:O35004" /translation="MRGFFGKAIFVVLAVFIMMPLLGIEAVRASELQQHVYDRAHLLS KAEIGKLESLSAKLGAKRDTDFIIITTKSTNGEDIADYTGDFYDRYGKGSTAILTIDM TNREVFIAGFKKAEQYLDNSRLNSIRNTISSDLSNENYFEAFETYIQLSYKDMGIKPG VNPDNIFFTWWFQLIAAIAVGGIAVSIMLYHAGGKVTVNGSTYMDQRTSDVIDQYDTY IRTTVTRERKPSDKDSGSDGGVTKGGTSYSGSRGSF*" /label="ydjH CDS" gene 597244..598008 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /label="ydjH gene" CDS 598039..599010 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388502.1" /db_xref="EnsemblGenomes-Gn:BSU06210" /db_xref="EnsemblGenomes-Tr:CAB12440" /db_xref="InterPro:IPR033880" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG12800" /db_xref="UniProtKB/Swiss-Prot:O34789" /translation="MSFFRNQLANVVEWEEFRDDMIFYKWNNREIKKGSRLIIRPGQD AVFLNNGRVEGVFQDDGDYDIESEIIPFLSTLKGFKFGFNSGMRAEVLFVNTKEFTVR WGTKQAINIPAAGMPGGMPIRANGTFNFKVQDYISLIDKIAGVKDQYFVEDIKTRIIS ILDQLLMKWITREGKDMFNLQANAFDIAKGIQEDLDMQLISDGMTVTGFQIMSFNYPQ EVQDMITKNASYGMVGDVNRYQQISMTDGMASGKMSGSGAASDMAGMMMGMNMANQMM NQMNQNQQAQSSGPQSTGSGSKPNFCPNCGTKTGEANFCPNCGQKLV*" /label="ydjI CDS" gene 598039..599010 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /label="ydjI gene" downshifts 599000 /Source="Nicolas_upshifts" /id="D300" /incds=0 /nref=180 /ntot=247 /MaxReadThrough="2.71622" /MaxDrop="5.81579" /score="16.72046" /energy="-11.1" /TU="U477" /idTUdmin="U477" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 599044 /Source="Nicolas_upshifts" /id="D301" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="2.13813" /MaxDrop="3.25329" /score="16.72046" /energy="-11.1" /TU="NA" /idTUdmin="U477" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(599057..600082) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane associated potassium channel; prophage region 3" /protein_id="NP_388503.1" /db_xref="EnsemblGenomes-Gn:BSU06220" /db_xref="EnsemblGenomes-Tr:CAB12441" /db_xref="GOA:O34733" /db_xref="InterPro:IPR013099" /db_xref="SubtiList:BG12801" /db_xref="UniProtKB/Swiss-Prot:O34733" /translation="MNEGYIIAGLLLLTAGMIDFLWTTLWLESGAGPITRCLSAWLWK GCRKISGDHAKVLSMAGPLLLCLTLVIWISLFWSGWVLIYSSDPHSLMETQSKEPASW SDRIYFSGYVMFTLGNGDLAPNGGLWKLVTIIETAQGLLTITFSVTYLISVLSAVNQK RSFAQSVLSLGHDGTEIVHNAWNGKDFHDIDFLLVAASSELGKLTAQHNAFPILHFYH STQHQESSIIAVAVLDEALTIFKYGIPEQYQPNQLHIKEARSSIKNYLDTVHTAYIHP AEQAPPEPDISKLQQSGIPALSKQTFQIAVNSIKERRQLLLGIIQAGARKWPVQEQAI GNAYSPK*" /label="ydjJ CDS" gene complement(599057..600082) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /label="ydjJ gene" promotor_-10 complement(600114..600133) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(600132) /Source="Nicolas_upshifts" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(600147..600153) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 600342..600349 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 600362 /Source="Nicolas_upshifts" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="upshifts" S_feature 600364..600666 /Source="Nicolas_S_feature" /locus_tag="new_676139_676441" /HighExp="M0t90, M40t90, Lbtran, T0.30H, BI, T1.0H, M9-stat, S1, T1.30H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.28450700000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S222" promotor_-10 600364..600383 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 600667..602088 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="myo-inositol transporter" /protein_id="NP_388504.1" /db_xref="EnsemblGenomes-Gn:BSU06230" /db_xref="EnsemblGenomes-Tr:CAB12442" /db_xref="GOA:O34718" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12802" /db_xref="UniProtKB/Swiss-Prot:O34718" /translation="MNKQGNQMSFLRTIILVSTFGGLLFGYDTGVLNGALPYMGEPDQ LNLNAFTEGLVTSSLLFGAALGAVFGGRMSDFNGRRKNILFLAVIFFISTIGCTFAPN VTVMIISRFVLGIAVGGASVTVPAYLAEMSPVESRGRMVTQNELMIVSGQLLAFVFNA ILGTTMGDNSHVWRFMLVIASLPALFLFFGMIRMPESPRWLVSKGRKEDALRVLKKIR DEKRAAAELQEIEFAFKKEDQLEKATFKDLSVPWVRRIVFIGLGIAIVQQITGVNSIM YYGTEILRNSGFQTEAALIGNIANGVISVLATFVGIWLLGRVGRRPMLMTGLIGTTTA LLLIGIFSLVLEGSPALPYVVLSLTVTFLAFQQGAISPVTWLMLSEIFPLRLRGLGMG VTVFCLWMVNFAVSFTFPILLAAIGLSTTFFIFVGLGICSVLFVKRFLPETKGLSLEQ LEENFRAYDHSGAKKDSGAEVIG*" /label="iolT CDS" gene 600667..602088 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /label="iolT gene" downshifts 602080 /Source="Nicolas_upshifts" /id="D302" /incds=0 /nref=11 /ntot=24 /MaxReadThrough="2.82455" /MaxDrop="8.02371" /score="11.3880907" /energy="-11.2" /TU="NA" /idTUdmin="U479" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(602136) /Source="Nicolas_upshifts" /id="D303" /incds=0 /nref=242 /ntot=272 /MaxReadThrough="1.00274" /MaxDrop="9.32541" /score="13.6781112" /energy="-11.2" /TU="NA" /idTUdmin="U482" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(602136..603176) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /EC_number="1.1.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12469342, 18820069, 24525333, 26428232, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12469342, 18820069, 24525333, 26428232, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin reductase/2,3-butanediol dehydrogenase" /protein_id="NP_388505.1" /db_xref="EnsemblGenomes-Gn:BSU06240" /db_xref="EnsemblGenomes-Tr:CAB12443" /db_xref="GOA:O34788" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12803" /db_xref="UniProtKB/Swiss-Prot:O34788" /translation="MKAARWHNQKDIRIEHIEEPKTEPGKVKIKVKWCGICGSDLHEY LGGPIFIPVDKPHPLTNETAPVTMGHEFSGEVVEVGEGVENYKVGDRVVVEPIFATHG HQGAYNLDEQMGFLGLAGGGGGFSEYVSVDEELLFKLPDELSYEQGALVEPSAVALYA VRSSKLKAGDKAAVFGCGPIGLLVIEALKAAGATDIYAVELSPERQQKAEELGAIIVD PSKTDDVVAEIAERTGGGVDVAFEVTGVPVVLRQAIQSTTIAGETVIVSIWEKGAEIH PNDIVIKERTVKGIIGYRDIFPAVLSLMKEGYFSADKLVTKKIVLDDLIEEGFGALIK EKSQVKILVRPN*" /label="bdhA CDS" gene complement(602136..603176) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /label="bdhA gene" promotor_-35 602716..602725 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 602739..602758 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 602740..603275 /Source="Nicolas_S_feature" /locus_tag="new_678515_679050" /HighExp="C30, Gly, S6, C90, S8, BT, S7, Sw, Fru, Lbstat" /AntisenseName="bdhA" /AntisenseCor="-0.174163895138467" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S223" upshifts 602740 /Source="Nicolas_upshifts" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(603177..603471) /Source="Nicolas_S_feature" /locus_tag="new_678952_679246_c" /HighExp="Lbtran, BI, T1.0H, M40t90, LBGstat, LoTm, T0.30H, LPhT, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S224" misc_feature 603276..603295 /Source="Nicolas_upshift_promotors" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 603277..603574 /Source="Nicolas_S_feature" /locus_tag="new_679052_679349" /HighExp="G180, Paraq, Oxctl, H2O2, G135, G150, MG 5, C30, UNK1, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S225" upshifts 603277 /Source="Nicolas_upshifts" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="upshifts" misc_feature complement(603466..603480) /Source="Nicolas_upshift_promotors" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(603471) /Source="Nicolas_upshifts" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 603573..603592 /Source="Nicolas_upshift_promotors" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 603576 /Source="Nicolas_upshifts" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="upshifts" CDS 603615..603986 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /experiment="publication(s) with functional evidences, PMID:17581128, 20487291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17581128, 20487291; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein involved in cell wall metabolism" /protein_id="NP_388506.1" /db_xref="EnsemblGenomes-Gn:BSU06250" /db_xref="EnsemblGenomes-Tr:CAB12444" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG11036" /db_xref="UniProtKB/Swiss-Prot:P40775" /translation="MLKKVILAAFILVGSTLGAFSFSSDASAKHVNGNITWYNGVGKK GSSGKKLGHWDCATKIGFDVPRNGTKIRAYAKAKPKKVITVYKNDVGRMPNAVLDVSP KAFKALGYPLSKGKVAGHYSY*" /label="walM CDS" gene 603615..603986 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /label="walM gene" downshifts 603972 /Source="Nicolas_upshifts" /id="D304" /incds=0 /nref=5 /ntot=52 /MaxReadThrough="5.74148" /MaxDrop="2.8439" /score="-1.55787542" /energy="-7.4" /TU="U483" /idTUdmin="U481" /TUdmin=418 /isTUend="FALSE" /label="downshifts" CDS 604052..605098 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388507.1" /db_xref="EnsemblGenomes-Gn:BSU06260" /db_xref="EnsemblGenomes-Tr:CAB12445" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12804" /db_xref="UniProtKB/Swiss-Prot:O34353" /translation="MKKRIILLLAVIIAAAAAGVAFYVAKDKGHEKAADVSVNTESGD ELLVSITDTDLLTKYYENDKVIHEEKLTSYPAFALDQKQQVLYYTGNNEQNEMRLFKL DLKSHKKTMLYKGAESADSLFLSKDRSTIYFRLGKADESNFRIAAFDLKTKKYKNLYP AANDQDDTVSSFFYNQKNDSFALLHYSVEEDYKKTDEANEKGIDPEPTTIHFAEGRQN KFNELKSLNQFISDIAVSDDDKRILFTSYTQKGTEQTASIQMLNADTKKYESIISNQK SFKLLIDAQPQFSKDGKNIYFLAEAKGAKKLKDETGREAKVRTIYSYSLENKTFKKVW ENPNGIINSFFVIN*" /label="ydjN CDS" gene 604052..605098 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /label="ydjN gene" downshifts 605072 /Source="Nicolas_upshifts" /id="D305" /incds=0 /nref=41 /ntot=177 /MaxReadThrough="1.73572" /MaxDrop="4.49184" /score="21.8200083" /energy="-13.9" /TU="NA" /idTUdmin="U483" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(605132..605290) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097689.1" /db_xref="EnsemblGenomes-Gn:BSU06269" /db_xref="EnsemblGenomes-Tr:CAX52576" /db_xref="GOA:O24817" /db_xref="UniProtKB/Swiss-Prot:O24817" /translation="MISNQQQKDLKKRAAFKKLNVAMNSYVELLFLSVPLIHIFKWLG SLALHLIH*" /label="ydzJ CDS" gene complement(605132..605290) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /label="ydzJ gene" downshifts complement(605148) /Source="Nicolas_upshifts" /id="D306" /incds=0 /nref=23 /ntot=155 /MaxReadThrough="0.7906" /MaxDrop="3.61386" /score="9.10659473" /energy="-10.1" /TU="NA" /idTUdmin="U487" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(605347..605479) /Source="Nicolas_S_feature" /locus_tag="new_681122_681254_c" /HighExp="LoTm, S8, S5, S6, S4, B36, S7, Cold, B60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigWXY" /TUshortPSig="0.994, 1, 1" /TUlongSig="SigK" /TUlongPSig="0.994" /label="S226" downshifts complement(605390) /Source="Nicolas_upshifts" /id="D307" /incds=0 /nref=57 /ntot=272 /MaxReadThrough="3.03092" /MaxDrop="6.46708" /score="5.41743429" /energy="-8.4" /TU="U484,U486,U487" /idTUdmin="U484" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(605480..605689) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28197687" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388508.1" /db_xref="EnsemblGenomes-Gn:BSU06270" /db_xref="EnsemblGenomes-Tr:CAB12446" /db_xref="InterPro:IPR025916" /db_xref="SubtiList:BG12805" /db_xref="UniProtKB/Swiss-Prot:O34759" /translation="MSYYNKRNQEPLPKEDVSTWECTKEDCNGWTRKNFASSDTPLCP LCGSKMVDGIRSLVNLQNNSQTKTS*" /label="ydjO CDS" gene complement(605480..605689) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /label="ydjO gene" promotor_-10 complement(605722..605741) /Source="Nicolas_upshift_promotors" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(605733) /Source="Nicolas_upshifts" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="upshifts" CDS complement(605772..606587) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9987136; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacrylate hydrolase" /protein_id="NP_388509.1" /db_xref="EnsemblGenomes-Gn:BSU06280" /db_xref="EnsemblGenomes-Tr:CAB12447" /db_xref="GOA:O34592" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12806" /db_xref="UniProtKB/Swiss-Prot:O34592" /translation="MPYIILEDQTRLYYETHGSGTPILFIHGVLMSGQFFHKQFSVLS ANYQCIRLDLRGHGESDKVLHGHTISQYARDIREFLNAMELDHVVLAGWSMGAFVVWD YLNQFGNDNIQAAVIIDQSASDYQWEGWEHGPFDFDGLKTAMHAIQTDPLPFYESFIQ NMFAEPPAETETEWMLAEILKQPAAISSTILFNQTAADYRGTLQNINVPALLCFGEDK KFFSTAAGEHLRSNIPNATLVTFPKSSHCPFLEEPDAFNSTLLSFLDGVIGKS*" /label="ydjP CDS" gene complement(605772..606587) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /label="ydjP gene" promotor_-35 606414..606423 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 606436..606455 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 606436 /Source="Nicolas_upshifts" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(606600..607589) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388510.1" /db_xref="EnsemblGenomes-Gn:BSU06290" /db_xref="EnsemblGenomes-Tr:CAB12448" /db_xref="InterPro:IPR025062" /db_xref="SubtiList:BG12210" /db_xref="UniProtKB/Swiss-Prot:O34803" /translation="MLTHDLHEKTKHYISIYAELKTKLKWKVSHDQILMLISSAYIVN KREFDFQRFYDLSSYIKSNIGSFSTLNSHHRFTVASILDIHFQHEAKQTFQTFIDVYN EMVKLGYKRDMFTYLSALILLTGKSETTNQKEQMNMGLAVYQQMKKNHYFLTSTQNVP LAVLLGENGKGLQALQKAETCYQLLAANGFKKGQYLHQVSHILALQSEKEPEMLVSAC KQIYQSITESVKKTKDYHYPDLALLTFLEEPDIKTVLCITDELNQEKAFKWQKEMNFK IAVSLYLSEHMEKNLLMESGLYTAIETVIQAQQAAATAAIISSTAASHTHDGN*" /label="yeaA CDS" gene complement(606600..607589) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /label="yeaA gene" promotor_-10 complement(607454..607472) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(607462) /Source="Nicolas_upshifts" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(607488..607493) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(607611..607626) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(607632) /Source="Nicolas_upshifts" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(607638..607647) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(607687..609228) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /EC_number="1.3.3.5" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="outer spore coat copper-dependent promiscuous laccase" /protein_id="NP_388511.1" /db_xref="EnsemblGenomes-Gn:BSU06300" /db_xref="EnsemblGenomes-Tr:CAB12449" /db_xref="GOA:P07788" /db_xref="InterPro:IPR001117" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011706" /db_xref="InterPro:IPR011707" /db_xref="PDB:1GSK" /db_xref="PDB:1OF0" /db_xref="PDB:1W6L" /db_xref="PDB:1W6W" /db_xref="PDB:1W8E" /db_xref="PDB:2BHF" /db_xref="PDB:2WSD" /db_xref="PDB:2X87" /db_xref="PDB:2X88" /db_xref="PDB:3ZDW" /db_xref="PDB:4A66" /db_xref="PDB:4A67" /db_xref="PDB:4A68" /db_xref="PDB:4AKO" /db_xref="PDB:4AKP" /db_xref="PDB:4AKQ" /db_xref="PDB:4Q89" /db_xref="PDB:4Q8B" /db_xref="PDB:4YVN" /db_xref="PDB:4YVU" /db_xref="SubtiList:BG10490" /db_xref="UniProtKB/Swiss-Prot:P07788" /translation="MTLEKFVDALPIPDTLKPVQQSKEKTYYEVTMEECTHQLHRDLP PTRLWGYNGLFPGPTIEVKRNENVYVKWMNNLPSTHFLPIDHTIHHSDSQHEEPEVKT VVHLHGGVTPDDSDGYPEAWFSKDFEQTGPYFKREVYHYPNQQRGAILWYHDHAMALT RLNVYAGLVGAYIIHDPKEKRLKLPSDEYDVPLLITDRTINEDGSLFYPSAPENPSPS LPNPSIVPAFCGETILVNGKVWPYLEVEPRKYRFRVINASNTRTYNLSLDNGGDFIQI GSDGGLLPRSVKLNSFSLAPAERYDIIIDFTAYEGESIILANSAGCGGDVNPETDANI MQFRVTKPLAQKDESRKPKYLASYPSVQHERIQNIRTLKLAGTQDEYGRPVLLLNNKR WHDPVTETPKVGTTEIWSIINPTRGTHPIHLHLVSFRVLDRRPFDIARYQESGELSYT GPAVPPPPSEKGWKDTIQAHAGEVLRIAATFGPYSGRYVWHCHILEHEDYDMMRPMDI TDPHK*" /label="cotA CDS" gene complement(607687..609228) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /label="cotA gene" downshifts complement(607700) /Source="Nicolas_upshifts" /id="D308" /incds=0 /nref=46 /ntot=93 /MaxReadThrough="2.97674" /MaxDrop="5.60726" /score="22.3755425" /energy="-9.1" /TU="U488" /idTUdmin="U488" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(609259..609278) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-10" upshifts complement(609273) /Source="Nicolas_upshifts" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="upshifts" promotor_-35 complement(609292..609301) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-35" CDS complement(609380..610789) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16547045, 16850406, 8951816, 9677314, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16547045, 16850406, 8951816, 9677314, 24142252; Product type t : transporter" /codon_start=1 /transl_table=11 /product="gamma-aminobutyrate (GABA) permease; proline permease" /protein_id="NP_388512.2" /db_xref="EnsemblGenomes-Gn:BSU06310" /db_xref="EnsemblGenomes-Tr:CAB12450" /db_xref="GOA:P46349" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="InterPro:IPR011265" /db_xref="SubtiList:BG11328" /db_xref="UniProtKB/Swiss-Prot:P46349" /translation="MNQSQSGLKKELKTRHMTMISIAGVIGAGLFVGSGSVIHSTGPG AVVSYALAGLLVIFIMRMLGEMSAVNPTSGSFSQYAHDAIGPWAGFTIGWLYWFFWVI VIAIEAIAGAGIIQYWFHDIPLWLTSLILTIVLTLTNVYSVKSFGEFEYWFSLIKVVT IIAFLIVGFAFIFGFAPGSEPVGFSNLTGKGGFFPEGISSVLLGIVVVIFSFMGTEIV AIAAGETSNPIESVTKATRSVVWRIIVFYVGSIAIVVALLPWNSANILESPFVAVLEH IGVPAAAQIMNFIVLTAVLSCLNSGLYTTSRMLYSLAERNEAPRRFMKLSKKGVPVQA IVAGTFFSYIAVVMNYFSPDTVFLFLVNSSGAIALLVYLVIAVSQLKMRKKLEKTNPE ALKIKMWLFPFLTYLTIIAICGILVSMAFIDSMRDELLLTGVITGIVLISYLVFRKRK VSEKAAANPVTQQQPDILP*" /label="gabP CDS" gene complement(609380..610789) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /label="gabP gene" downshifts complement(609394) /Source="Nicolas_upshifts" /id="D309" /incds=0 /nref=124 /ntot=216 /MaxReadThrough="3.22899" /MaxDrop="5.0359" /score="18.985683" /energy="-13.5" /TU="U489" /idTUdmin="U489" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(610827..611114) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097690.1" /db_xref="EnsemblGenomes-Gn:BSU06319" /db_xref="EnsemblGenomes-Tr:CAX52577" /db_xref="UniProtKB/Swiss-Prot:C0H3X2" /translation="MIHPPQKNSDEGTLFLSSNLFAPPKIPSNPRTPVLLAFYRIVNI TQNHTANKKRNIFSTHSLKAQTKHYKFEISWYIFLHEFSTNCIFMIEFQLS*" /label="ydzX CDS" gene complement(610827..611114) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /label="ydzX gene" misc_feature complement(610830..610849) /Source="Nicolas_upshift_promotors" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(610844) /Source="Nicolas_upshifts" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="upshifts" promotor_-35 611120..611127 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 611143..611162 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 611144 /Source="Nicolas_upshifts" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="upshifts" CDS 611187..612059 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="secondary Mn(II) exporter, promiscuous" /protein_id="NP_388513.1" /db_xref="EnsemblGenomes-Gn:BSU06320" /db_xref="EnsemblGenomes-Tr:CAB12451" /db_xref="GOA:P46348" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG11329" /db_xref="UniProtKB/Swiss-Prot:P46348" /translation="MERYDELKKGESGALVSIAAYLVLSAIKLIIGYLFHSEALTADG LNNTTDIIASVAVLIGLRISQKPPDEDHPYGHFRAETIASLIASFIMMVVGLQVLFSA GESIFSAKQETPDMIAAWTAAGGAVLMLIVYRYNKRLAKKVKSQALLAAAADNKSDAF VSIGTFIGIVAAQFHLAWIDTVTAFVIGLLICKTAWDIFKESSHSLTDGFDIKDISAY KQTIEKISGVSRLKDIKARYLGSTVHVDVVVEVSADLNITESHDIANEIERRMKEEHA IDYSHVHMEPLEQK*" /label="mneS CDS" gene 611187..612059 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /label="mneS gene" downshifts 612024 /Source="Nicolas_upshifts" /id="D310" /incds=0 /nref=2 /ntot=88 /MaxReadThrough="1.72291" /MaxDrop="2.86431" /score="24.8167732" /energy="-10.2" /TU="U490" /idTUdmin="U490" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts complement(612299) /Source="Nicolas_upshifts" /id="D311" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="0.65827" /MaxDrop="3.33542" /score="-0.424989042" /energy="-12.9" /TU="NA" /idTUdmin="U489" /TUdmin="-3015" /isTUend="FALSE" /label="downshifts" misc_feature 612353..612372 /Source="Nicolas_upshift_promotors" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 612363 /Source="Nicolas_upshifts" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="upshifts" CDS 612409..613371 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21907250, 26933057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative MoxR-like ATPase" /protein_id="NP_388514.2" /db_xref="EnsemblGenomes-Gn:BSU06330" /db_xref="EnsemblGenomes-Tr:CAB12452" /db_xref="GOA:P94474" /db_xref="InterPro:IPR011703" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12211" /db_xref="UniProtKB/Swiss-Prot:P94474" /translation="MAYQEDLHPLLGKAVEHINRVMVGKRDIAILSLAALLAKGHVLL EDVPGVGKTMMVRALAKSIGADFKRIQFTPDLLPSDVTGVSIYNAKTMEFEYRPGPIM GNIVLADEINRTSPKTQSALLEAMEEGSVTVDGHTMQLADPFFVMATQNPVEYEGTYP LPEAQLDRFLFKLRMGYPSFNEELDVLSLQEKSHPIETLEPVIAKEDFIFLQREVQNV RADDSIKEYIVEIVQKTRQHPSVQLGVSPRGSIALMKAAQAYALLHHRDYVIPDDIQY LAPFTLPHRMMLHPEAKFEGIQAEAIVREIMSAVKVPVQRSAVR*" /label="yeaC CDS" gene 612409..613371 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /label="yeaC gene" CDS 613371..614567 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388515.2" /db_xref="EnsemblGenomes-Gn:BSU06340" /db_xref="EnsemblGenomes-Tr:CAB12453" /db_xref="InterPro:IPR002881" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12212" /db_xref="UniProtKB/Swiss-Prot:P94475" /translation="MNKKWQWLVYGWKLIILTLLTAAVFSYAMFQGGFVSWFLFYAFL PFVLYAGLLALYPLRSFQASRQMDKTQLHAGDRLGVTVTLRRKLPFPLMYMVIEDCLP EGIESLNRDGAAAKRLVFPWFKRSMTMSYELARVPRGEHHFHSVRVRTGDVLGLIEKT AFFELDDTLFVYPFYQRFSYQVNERHQEDGVSGSSPIHQHHSSVAASVRNYQPGDRFA ALDWKTSARRSQLMTKEFEPSRSKNLFLLMDRFSSDAFEEVVSVTASILHSVLKNGAG AGLASIGKEKNIFPIQEGDQHFKHMLRHLAIAHCDAADPISRYAREELGKPSVRQADQ VVVTGQLTEDMLHLAEIGGGRVTVILAKEKDAELSQAENVMIERMMKRQIRVRIMRGG RVSRVV*" /label="yeaD CDS" gene 613371..614567 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /label="yeaD gene" CDS 614589..616802 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388516.2" /db_xref="EnsemblGenomes-Gn:BSU06350" /db_xref="EnsemblGenomes-Tr:CAB12454" /db_xref="GOA:P94476" /db_xref="InterPro:IPR002931" /db_xref="InterPro:IPR025403" /db_xref="InterPro:IPR036985" /db_xref="SubtiList:BG12213" /db_xref="UniProtKB/Swiss-Prot:P94476" /translation="MPHDDHKGSRLSLLLFYFLAFLLLWEWLRPLDSFTETKHTGFFS VFIGLTFLLTFFRMRWFVTVPFCVIFTLISIHILFYQGSIFDLSWVSSFLQDVYLNIT LIQSGQWNDMIPSFRTLLFFVLLWLLVYLLHYWVIYQRRILFFFLMTVAYITILDTFT PYDATFAVIRIVLIGFFMLGLLYLERIKLMERITLPKTSVLKWFLPLSVLVLAATGFG LAAPKSEPAWPDPVPFLKKITHQDRVSAGESKIGYGNHDESLGGPFQQDATPVFTWQG KERTYFRVETKDTYTGKGWIETDTGMSYQLSNGKVENLWFDHKVATERRTVRVKVDKH YGYNHLMYPIGAETIQPKQAVSLEMNGNTEQISPISEQAGEIRNMGNYTVTYNSPVYK LDELRKVKVRKNSEEYTFSDRYMQLPDSLPERVRTLAIKLTQDHDNMFDKVKAVEDYL GSNAFTYETENVTIPKNDEDYVDQFLFETKMGYCDNFSSAMVVLLRSAGIPARWVKGY TSGEYKEAGNKNGSIYEVTNNNAHSWVEVYFPEQGWVTFEPTKGFTNPAQFTSSDTKD SGSDSSSSPKKAKEKQKEEKKQPQKEEKQKEKREPAVSKKPSASHTNAGAGLYAALAV LAVLLVAAVLLYVFRSLWIPVFAVRKLKRRSDQHAFFEAYGALLKQLKRKGLPKRDSE TLRDYAKRIDEKYDIEDMSKLTLSYERALYRNEDSSALWNDSRELWENLIKRRWS*" /label="yebA CDS" gene 614589..616802 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /label="yebA gene" promotor_-35 616797..616804 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 616819..616838 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 616835..616964 /Source="Nicolas_S_feature" /locus_tag="new_692610_692739" /HighExp="G180, Oxctl, G135, LBGexp, G150, Paraq, C30, LPh, MG 25, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63292099999999996" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S227" upshifts 616835 /Source="Nicolas_upshifts" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="upshifts" CDS 616965..618506 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /EC_number="6.3.5.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1312531, 21856856; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP synthetase" /protein_id="NP_388517.2" /db_xref="EnsemblGenomes-Gn:BSU06360" /db_xref="EnsemblGenomes-Tr:CAB12455" /db_xref="GOA:P29727" /db_xref="InterPro:IPR001674" /db_xref="InterPro:IPR004739" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022955" /db_xref="InterPro:IPR025777" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10647" /db_xref="UniProtKB/Swiss-Prot:P29727" /translation="MTKLVNEMILVLDFGSQYNQLITRRIREFGVYSELHPHTLTAEE IKKMNPKGIILSGGPNSVYDENSFRCDEKIFELDIPVLGICYGMQLMTHYLGGKVEAA SQREYGKANIRIEGTPDLFRDLPNEQVVWMSHGDLVVEVPEGFTVDATSHHCPNSAMS KADKKWYGVQFHPEVRHSEYGNDLLKNFVFGVCECEGEWSMENFIEIEMQKIRETVGD KQVLCALSGGVDSSVVAVLIHKAIGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFNMNV IKVDAKDRFLNKLKGVSDPEQKRKIIGNEFIYVFDDEADKLKGIDYLAQGTLYTDIIE SGTATAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTELGIPDEIVWRQPFP GPGLGIRVLGEVTEEKLEIVRESDAILREEIANHGLERDIWQYFTVLPDIRSVGVMGD ARTYDYTIGIRAVTSIDGMTSDWARIPWDVLEVISTRIVNEVKHINRVVYDITSKPPA TIEWE*" /label="guaA CDS" gene 616965..618506 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /label="guaA gene" downshifts 618492 /Source="Nicolas_upshifts" /id="D312" /incds=0 /nref=247 /ntot=268 /MaxReadThrough="2.12151" /MaxDrop="7.3702" /score="22.5795134" /energy="-18.5" /TU="NA" /idTUdmin="U492" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 618613..618617 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-35" promotor_-10 618633..618652 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-10" upshifts 618643 /Source="Nicolas_upshifts" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="upshifts" misc_RNA 618650..618752 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" /label="gswC RNA" gene 618650..618752 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /label="gswC gene" downshifts 618778 /Source="Nicolas_upshifts" /id="D313" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="8.01916" /MaxDrop="4.7859" /score="24.3821572" /energy="-11.3" /TU="U493" /idTUdmin="U492" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 618887..620209 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3110131, 11591660, 12923093, 15849754, 16850406, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 11591660, 12923093, 15849754, 16850406, 19446032; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_388518.1" /db_xref="EnsemblGenomes-Gn:BSU06370" /db_xref="EnsemblGenomes-Tr:CAB12456" /db_xref="GOA:O34987" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG12811" /db_xref="UniProtKB/Swiss-Prot:O34987" /translation="MKTFFQFDELGTSYRNEIIGGLTTFLSMAYILFVNPITLALESV KDFPEALRIDQGAVFTATALASAAGCILMGLIARYPIAIAPGMGLNAFFAFSVVLGMG ISWQAALSGVFISGLIFVALSLTGFREKIINAIPPELKLAVGAGIGLFITFVGLQGSG IITANPSTLVTIGNIHSGPVLLTIFGVIVTVILMVLRVNAGVFIGMLLTAVAGMIFGL VPVPTQIIGSVPSLAPTFGQAWIHLPDIFSVQMLIVILTFLFVGFFDTAGTLVAVATQ AGLMKENKLPRAGRALLADSSSIVIGAVLGTSTTTSYVESSSGVAAGARSGFAAIVTG ILFLLATFFSPLLSVVTSNVTAPALIIVGALMVAPLGKIAWDKFEVAVPAFLTMIMMP LTYSIATGIAIGFIFYPITMVCKGKAKEVHPIMYGLFVVFILYFIFLK*" /label="pbuG CDS" gene 618887..620209 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /label="pbuG gene" downshifts 620187 /Source="Nicolas_upshifts" /id="D314" /incds=0 /nref=47 /ntot=153 /MaxReadThrough="4.18958" /MaxDrop="4.86237" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-86" /isTUend="FALSE" /label="downshifts" downshifts 620230 /Source="Nicolas_upshifts" /id="D315" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="3.09696" /MaxDrop="3.87785" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-43" /isTUend="FALSE" /label="downshifts" promotor_-35 620259..620268 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 620279..620419 /Source="Nicolas_S_feature" /locus_tag="new_696054_696194" /HighExp="T1.30H, T1.0H, T2.0H, T0.30H, B60, T2.30H, T-0.40H, T0.0H, T3.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S228" upshifts 620279 /Source="Nicolas_upshifts" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 620281..620296 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 620420..621223 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388519.2" /db_xref="EnsemblGenomes-Gn:BSU06380" /db_xref="EnsemblGenomes-Tr:CAB12457" /db_xref="GOA:O34341" /db_xref="SubtiList:BG12812" /db_xref="UniProtKB/Swiss-Prot:O34341" /translation="MTEERKETFEEEINQSERIDADEEPLSRMSRKASRQSKQKQKQK QKPRQERGESTVKDKLASVWAAINRYCGFAFSILKSPAKTVVTDGFSHYKYGLISMLI FSIIFSIGNWFQLKASWNRPLGFGERHHAFYDGFLVVLVYLLIFFAVMVFAIWAVSRY MMKQKVTFREAAAVLGSLLVPVIAVSILWLIFAIVNIPMLTVLFTVLILFSIFFIIAL YVQRVYQAAQDAPIDYIYCVFAVVAIALLFTAVTWPFISEYITASLIPL*" /label="yebC CDS" gene 620420..621223 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /label="yebC gene" downshifts 621208 /Source="Nicolas_upshifts" /id="D316" /incds=0 /nref=218 /ntot=263 /MaxReadThrough="1.47691" /MaxDrop="7.03926" /score="33.0377004" /energy="-10.7" /TU="NA" /idTUdmin="U494" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 621291..621298 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 621312..621331 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 621318..621381 /Source="Nicolas_S_feature" /locus_tag="new_697093_697156" /HighExp="B60, S2, S7, S8, Lbstat, nit, S4, BC, BT, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S229" upshifts 621318 /Source="Nicolas_upshifts" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="upshifts" CDS 621382..621549 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388520.3" /db_xref="EnsemblGenomes-Gn:BSU06390" /db_xref="EnsemblGenomes-Tr:CAB12458" /db_xref="InterPro:IPR025072" /db_xref="SubtiList:BG12813" /db_xref="UniProtKB/Swiss-Prot:O34904" /translation="MADVLRRAINQKKQFLKTKLLLSEFYQGRGEQLADYTLSELEKE YKSLQKMKKEI*" /label="yebD CDS" gene 621382..621549 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /label="yebD gene" downshifts 621556 /Source="Nicolas_upshifts" /id="D317" /incds=0 /nref=64 /ntot=163 /MaxReadThrough="2.85884" /MaxDrop="5.66286" /score="29.2645456" /energy="-9" /TU="NA" /idTUdmin="U495" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 621600..621606 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 621621..621639 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 621624..621710 /Source="Nicolas_S_feature" /locus_tag="new_697399_697485" /HighExp="Etha, Gly, M9-stat, Sw, B60, S4, S6, LPhT, S3, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S230" upshifts 621624 /Source="Nicolas_upshifts" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 621689..621696 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 621710..621729 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 621712 /Source="Nicolas_upshifts" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="upshifts" CDS 621763..622317 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388521.2" /db_xref="EnsemblGenomes-Gn:BSU06400" /db_xref="EnsemblGenomes-Tr:CAB12459" /db_xref="GOA:O34624" /db_xref="InterPro:IPR019264" /db_xref="InterPro:IPR022930" /db_xref="SubtiList:BG12814" /db_xref="UniProtKB/Swiss-Prot:O34624" /translation="MMQTILSNGIAMVLIILIINIVYVSFFTIRMILTLKGQRYLAAG ISTIEILVYVTGLSLVLDNLDQIQNVIAYALGYGLGVIVGMKIEEKLALGYIMVNVIT KELDLDLPKQLREKGYGVTNWVAGGLEGDRTALQILTPRRYELQLYDTIKTLDSKAFI IAYEPKTIHGGFWVKAVKKRRIKE*" /label="yebE CDS" gene 621763..622317 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /label="yebE gene" CDS 622317..622514 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388523.1" /db_xref="EnsemblGenomes-Gn:BSU06410" /db_xref="EnsemblGenomes-Tr:CAB12461" /db_xref="InterPro:IPR025930" /db_xref="SubtiList:BG12816" /db_xref="UniProtKB/Swiss-Prot:O34700" /translation="MAKPKKKKFEVTEQQTIDAVLQQMKEEGYLPVRRMEEPIFMEKK ENGSIQIVPCGKKIVFEGKLI*" /label="yebG CDS" gene 622317..622514 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /label="yebG gene" downshifts 622504 /Source="Nicolas_upshifts" /id="D318" /incds=0 /nref=2 /ntot=91 /MaxReadThrough="2.80904" /MaxDrop="2.65424" /score="17.462689" /energy="-17.6" /TU="U496" /idTUdmin="U497" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 622560..622567 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 622582..622601 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 622584 /Source="Nicolas_upshifts" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 622594..622696 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" /label="gswD RNA" gene 622594..622696 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /label="gswD gene" S_feature 622697..622836 /Source="Nicolas_S_feature" /locus_tag="new_698472_698611" /HighExp="MG 10, MG 15, MG t5, BMM, MG 25, MG 5, HPh, GM 45, GM 90, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S231" CDS 622837..623325 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /EC_number="5.4.99.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12787499, 16138311, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide mutase" /protein_id="NP_388524.1" /db_xref="EnsemblGenomes-Gn:BSU06420" /db_xref="EnsemblGenomes-Tr:CAB12462" /db_xref="GOA:P12044" /db_xref="InterPro:IPR000031" /db_xref="InterPro:IPR024694" /db_xref="InterPro:IPR033747" /db_xref="InterPro:IPR035893" /db_xref="SubtiList:BG10700" /db_xref="UniProtKB/Swiss-Prot:P12044" /translation="MQPLVGIIMGSTSDWETMKHACDILDELNVPYEKKVVSAHRTPD FMFEYAETARERGIKVIIAGAGGAAHLPGMTAAKTTLPVIGVPVQSKALNGMDSLLSI VQMPGGVPVATTSIGKAGAVNAGLLAAQILSAFDEDLARKLDERRENTKQTVLESSDQ LV*" /label="purE CDS" gene 622837..623325 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /label="purE gene" CDS 623318..624460 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /EC_number="6.3.4.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8998996, 9683488, 21931218, 25372694; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide synthase" /protein_id="NP_388525.2" /db_xref="EnsemblGenomes-Gn:BSU06430" /db_xref="EnsemblGenomes-Tr:CAB12463" /db_xref="GOA:P12045" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005875" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10701" /db_xref="UniProtKB/Swiss-Prot:P12045" /translation="MSKQIIYPGAVIGIIGGGQLGKMMAVSAKQMGYKVAVVDPVKDS PCGQVADVEITAHYNDREAIRKLAEISDIITYEFENIDYDALHWLKDHAYLPQGSELL LITQNRETEKKAIQSAGCEVAPYSIVKTKNELKQAVQELRLPAVLKTCRGGYDGKGQF VIKEEAQMEQAAALLEHGTCILESWVSFKMELSVIVVRSVNGEISTFPTAENIHHNNI LFQSIVPARVEKGIQQKAADLAVKLADELNLVGPLAVEMFLTEDGELLVNELAPRPHN SGHYTLDLCETSQFEQHIRAVCGLPLGKTDLLKPGMMVNLLGDEVKLVEEDPELLKEA KLYIYGKHEIKKGRKMGHITFMKQPEDEWIQEITNKWMNRDGGQAE*" /label="purK CDS" gene 623318..624460 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /label="purK gene" CDS 624457..625752 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /EC_number="4.3.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9622500, 9683488, 9890879, 11063569, 12787499; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate lyase" /protein_id="NP_388526.1" /db_xref="EnsemblGenomes-Gn:BSU06440" /db_xref="EnsemblGenomes-Tr:CAB12464" /db_xref="GOA:P12047" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004769" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR019468" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="PDB:1F1O" /db_xref="SubtiList:BG10702" /db_xref="UniProtKB/Swiss-Prot:P12047" /translation="MIERYSRPEMSAIWTDENRFQAWLEVEILACEAWAELGVIPKED VKVMRENASFDINRILEIEKDTRHDVVAFTRAVSESLGEERKWVHYGLTSTDVVDTAL SYLLKQANDILLKDLERFVDIIKEKAKEHKYTVMMGRTHGVHAEPTTFGLKLALWHEE MKRNLERFKQAKAGIEVGKISGAVGTYANIDPFVEQYVCEKLGLKAAPISTQTLQRDR HADYMATLALIATSIEKFAVEIRGLQKSETREVEEFFAKGQKGSSAMPHKRNPIGSEN MTGMARVIRGYMMTAYENVPLWHERDISHSSAERIILPDATIALNYMLNRFSNIVKNL TVFPENMKRNMDRTLGLIYSQRVLLALIDTGLTREEAYDTVQPKAMEAWEKQVPFREL VEAEEKITSRLSPEKIADCFDYNYHLKNVDLIFERLGLA*" /label="purB CDS" gene 624457..625752 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /label="purB gene" promotor_-10 complement(624762..624781) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(624783) /Source="Nicolas_upshifts" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(624796..624803) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 625826..626551 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /EC_number="6.3.2.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2495272, 9683488, 10784038, 12787499, 26118696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole succinocarboxamide synthetase" /protein_id="NP_388527.1" /db_xref="EnsemblGenomes-Gn:BSU06450" /db_xref="EnsemblGenomes-Tr:CAB12465" /db_xref="GOA:P12046" /db_xref="InterPro:IPR001636" /db_xref="InterPro:IPR018236" /db_xref="InterPro:IPR028923" /db_xref="InterPro:IPR033934" /db_xref="SubtiList:BG10703" /db_xref="UniProtKB/Swiss-Prot:P12046" /translation="MNIVKNELLYEGKAKKIYKTDDENTLYVVYKDSATAFNGEKKAE ISGKGRLNNEISSLIFKHLHAKGINNHFIERISETEQLIKKVTIVPLEVVVRNVVAGS MSKRLGIPEGTELEQPIIEFYYKDDALGDPLITEDHIWLLKAATPEQVETIKSITTIV NEELQSIFDDCHVRLIDFKLEFGLDAEGQVLLADEISPDTCRLWDKETNEKLDKDLFR RNLGSLTDAYEEIFNRLGGIHHV*" /label="purC CDS" gene 625826..626551 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /label="purC gene" CDS 626544..626798 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10784038, 12787499" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10784038, 12787499; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for phosphoribosylformylglycinamidine synthetase activity" /protein_id="NP_388528.1" /db_xref="EnsemblGenomes-Gn:BSU06460" /db_xref="EnsemblGenomes-Tr:CAB12466" /db_xref="GOA:P12049" /db_xref="InterPro:IPR003850" /db_xref="InterPro:IPR036604" /db_xref="PDB:1T4A" /db_xref="PDB:1TWJ" /db_xref="SubtiList:BG10704" /db_xref="UniProtKB/Swiss-Prot:P12049" /translation="MYKVKVYVSLKESVLDPQGSAVQHALHSMTYNEVQDVRIGKYME LTIEKSDRDLDVLVKEMCEKLLANTVIEDYRYEVEEVVAQ*" /label="purS CDS" gene 626544..626798 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /label="purS gene" CDS 626795..627478 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301530, 15301532, 10784038, 9683488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301530, 15301532, 10784038, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit I" /protein_id="NP_388529.1" /db_xref="EnsemblGenomes-Gn:BSU06470" /db_xref="EnsemblGenomes-Tr:CAB12467" /db_xref="GOA:P12041" /db_xref="InterPro:IPR010075" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10706" /db_xref="UniProtKB/Swiss-Prot:P12041" /translation="MKFAVIVLPGSNCDIDMYHAVKDELGHEVEYVWHEETSLDGFDG VLIPGGFSYGDYLRCGAIARFANIMPAVKQAAAEGKPVLGVCNGFQILQELGLLPGAM RRNKDLKFICRPVELIVQNDETLFTASYEKGESITIPVAHGEGNFYCDDETLATLKEN NQIAFTYGSNINGSVSDIAGVVNEKGNVLGMMPHPERAVDELLGSADGLKLFQSIVKN WRETHVTTA*" /label="purQ CDS" gene 626795..627478 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /label="purQ gene" CDS 627462..629690 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301532, 10784038, 9683488, 21671997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301532, 10784038, 9683488, 21671997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit II" /protein_id="NP_388530.2" /db_xref="EnsemblGenomes-Gn:BSU06480" /db_xref="EnsemblGenomes-Tr:CAB12468" /db_xref="GOA:P12042" /db_xref="InterPro:IPR010074" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10705" /db_xref="UniProtKB/Swiss-Prot:P12042" /translation="MSLLLEPSKEQIKEEKLYQQMGVSDDEFALIESILGRLPNYTEI GIFSVMWSEHCSYKNSKPILRKFPTSGERVLQGPGEGAGIVDIGDNQAVVFKIESHNH PSALEPYQGAATGVGGIIRDVFSMGARPIAVLNSLRFGELTSPRVKYLFEEVVAGIAG YGNCIGIPTVGGEVQFDSSYEGNPLVNAMCVGLINHEDIKKGQAKGVGNTVMYVGAKT GRDGIHGATFASEEMSDSSEEKRSAVQVGDPFMEKLLLEACLEVIQCDALVGIQDMGA AGLTSSSAEMASKAGSGIEMNLDLIPQRETGMTAYEMMLSESQERMLLVIERGREQEI IDIFDKYDLEAVSVGHVTDDKMLRLTHKGEVVCELPVDALAEEAPVYHKPSQEPAYYR EFLETDVPAPQIEDANEMLKALLQQPTIASKEWVYDQYDYMVRTNTVVAPGSDAGVLR IRGTKKALAMTTDCNARYLYLDPEVGGKIAVAEAARNIICSGAEPLAVTDNLNFGNPE KPEIFWQIEKAADGISEACNVLSTPVIGGNVSLYNESNGTAIYPTPVIGMVGLIEDTA HITTQHFKQAGDLVYVIGETKPEFAGSELQKMTEGRIYGKAPQIDLDVELSRQKALLD AIKKGFVQSAHDVSEGGLGVAIAESVMTTENLGANVTVEGEAALLFSESQSRFVVSVK KEHQAAFEATVKDAVHIGEVTADGILAIQNQDGQQMIHAQTKELERVWKGAIPCLLKS KA*" /label="purL CDS" gene 627462..629690 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /label="purL gene" downshifts complement(627710) /Source="Nicolas_upshifts" /id="D319" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="0.69202" /MaxDrop="3.99287" /score="-6.56256716" /energy="-16.7" /TU="NA" /idTUdmin="U499" /TUdmin="-3147" /isTUend="FALSE" /label="downshifts" CDS 629666..631096 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /EC_number="2.4.2.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 10049369, 12787499, 16321950, 17981983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 10049369, 12787499, 16321950, 17981983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine phosphoribosylpyrophosphate amidotransferase" /protein_id="NP_388531.2" /db_xref="EnsemblGenomes-Gn:BSU06490" /db_xref="EnsemblGenomes-Tr:CAB12469" /db_xref="GOA:P00497" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005854" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR035584" /db_xref="PDB:1AO0" /db_xref="PDB:1GPH" /db_xref="SubtiList:BG10707" /db_xref="UniProtKB/Swiss-Prot:P00497" /translation="MLAEIKGLNEECGVFGIWGHEEAPQITYYGLHSLQHRGQEGAGI VATDGEKLTAHKGQGLITEVFQNGELSKVKGKGAIGHVRYATAGGGGYENVQPLLFRS QNNGSLALAHNGNLVNATQLKQQLENQGSIFQTSSDTEVLAHLIKRSGHFTLKDQIKN SLSMLKGAYAFLIMTETEMIVALDPNGLRPLSIGMMGDAYVVASETCAFDVVGATYLR EVEPGEMLIINDEGMKSERFSMNINRSICSMEYIYFSRPDSNIDGINVHSARKNLGKM LAQESAVEADVVTGVPDSSISAAIGYAEATGIPYELGLIKNRYVGRTFIQPSQALREQ GVRMKLSAVRGVVEGKRVVMVDDSIVRGTTSRRIVTMLREAGATEVHVKISSPPIAHP CFYGIDTSTHEELIASSHSVEEIRQEIGADTLSFLSVEGLLKGIGRKYDDSNCGQCLA CFTGKYPTEIYQDTVLPHVKEAVLTK*" /label="purF CDS" gene 629666..631096 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /label="purF gene" S_feature 631097..631197 /Source="Nicolas_S_feature" /locus_tag="new_706872_706972" /HighExp="MG 15, MG 25, MG 10, MG 5, aero, S0, MG t5, Gly, LPh, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S232" CDS 631198..632238 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /EC_number="6.3.3.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10508786, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole synthetase" /protein_id="NP_388532.2" /db_xref="EnsemblGenomes-Gn:BSU06500" /db_xref="EnsemblGenomes-Tr:CAB12470" /db_xref="GOA:P12043" /db_xref="InterPro:IPR004733" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10708" /db_xref="UniProtKB/Swiss-Prot:P12043" /translation="MSEAYKNAGVDIEAGYEAVKRMKKHVERTKRLGVMGSLGGFGGM FDLSELSYQKPVLISGTDGVGTKLKLAFSMDKHDTIGVDAVAMCVNDVLAQGAEPLFF LDYLAVGKADPVKIEQIVQGVAEGCEQSGSALVGGETAEMPGLYTADEYDIAGFSVGV AEKDEIVTGEKIEEGHLLIGLSSSGLHSNGFSLVRKVLLDDAELDLDTTYEPFERPLG EELLEPTRIYVKPVLAAVKSGKIDGMAHVTGGGFIENIPRMLPEGLSAEIDHGSWPIP PIFSFLQEYGKLKEEDMFNVFNMGIGFVLAVKEEHLTDVIGTLESHGEKAYLIGRVKK GEGVTFGGAALS*" /label="purM CDS" gene 631198..632238 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /label="purM gene" CDS 632235..632822 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /EC_number="2.1.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10569930, 12787499, 19574646; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase" /protein_id="NP_388533.2" /db_xref="EnsemblGenomes-Gn:BSU06510" /db_xref="EnsemblGenomes-Tr:CAB12471" /db_xref="GOA:P12040" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR004607" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG10709" /db_xref="UniProtKB/Swiss-Prot:P12040" /translation="MKKFAVFASGNGSNFEAIVTRLKEENWDASAALLVCDKPQAKVI ERAEAFHIPSFAFEPKSYENKAAFEQAIIEQLRLHEVELIALAGYMRLIGDTLLQAYG GKIINIHPSLLPAFPGIDAVGQAFRAGVKVAGITVHYVDEGMDTGPIIAQKAIEIDEH DTLETIEQRIHKLEHKWYPSVIKQLLGLNNRGEKA*" /label="purN CDS" gene 632235..632822 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /label="purN gene" misc_feature 632245..632259 /Source="Nicolas_upshift_promotors" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 632254 /Source="Nicolas_upshifts" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(632521..632539) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(632528) /Source="Nicolas_upshifts" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(632555..632560) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 632819..634357 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /EC_number="2.1.2.3" /EC_number="3.5.4.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12787499, 1937050, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused phosphoribosylaminoimidazole carboxy formyl formyltransferase; inosine-monophosphate cyclohydrolase" /protein_id="NP_388534.2" /db_xref="EnsemblGenomes-Gn:BSU06520" /db_xref="EnsemblGenomes-Tr:CAB12472" /db_xref="GOA:P12048" /db_xref="InterPro:IPR002695" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024051" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10710" /db_xref="UniProtKB/Swiss-Prot:P12048" /translation="MTIKRALISVSDKTNLVPFVKELTELGVEVISTGGTKKLLQENG VDVIGISEVTGFPEIMDGRLKTLHPNIHGGLLAVRGNEEHMAQINEHGIQPIDLVVVN LYPFKETISKEDVTYEEAIENIDIGGPGMLRAASKNHQDVTVIVDPADYSPVLNQIKE EGSVSLQKKRELAAKVFRHTAAYDALIADYLTNVVGEKEPEQFTVTFEKKQSLRYGEN PHQEATFYQTALPVKGSIAQAEQLHGKELSYNNIKDADAAVQIVREFTEPAAVAVKHM NPCGVGTGKTIAEAFDRAFEADKTSIFGGIIALNREVDKATAEALHNIFLEIIIAPSF SQEALDVLTAKKNLRLLTLDVSAAVQKEKQLTSVQGGLLIQDLDMHGFDDAEISIPTK REPNEQEWEDLKLAWKVVKHVKSNAIVLAKDNMTVGVGAGQMNRVGSAKIAIEQAGEK AKGSALGSDAYFPMPDTVEEAAKAGVTAIIQPGGSIRDEDSIKKADEYGIAMVFTGIR HFKH*" /label="purH CDS" gene 632819..634357 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /label="purH gene" CDS 634373..635641 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /EC_number="6.3.4.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 12787499, 16321950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide synthetase" /protein_id="NP_388535.1" /db_xref="EnsemblGenomes-Gn:BSU06530" /db_xref="EnsemblGenomes-Tr:CAB12473" /db_xref="GOA:P12039" /db_xref="InterPro:IPR000115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR020559" /db_xref="InterPro:IPR020560" /db_xref="InterPro:IPR020561" /db_xref="InterPro:IPR020562" /db_xref="InterPro:IPR037123" /db_xref="PDB:2XCL" /db_xref="PDB:2XD4" /db_xref="SubtiList:BG10711" /db_xref="UniProtKB/Swiss-Prot:P12039" /translation="MNVLIIGKGGREHTLAWKAAQSSLVENVFAAPGNDGMAASAQLV NIEESDHAGLVSFAKQNQVGLTIVGPEVPLIEGLVDEFEKAGLHVFGPSKAAAIIEGS KQFAKDLMKKYDIPTAEYETFTSFDEAKAYVQEKGAPIVIKADGLAAGKGVTVAMTEE EAIACLHDFLEDEKFGDASASVVIEEYLSGEEFSLMAFVKGEKVYPMVIAQDHKRAFD GDKGPNTGGMGAYSPVPQISEETVRHAVETIVKPAAKAMVQEGRSFTGVLYAGLMLTE NGSKVIEFNARFGDPETQVVLPRMESDLVQVLLDLLDDKEVDLRWKDTAAVSVVLASE GYPESYAKGTPIGSLAAETEQVVVFHAGTKAEGGEFVTNGGRVANVTAFDETFEAARD RVYKAVDEIFKPGLFFRKDIGARALKAAQK*" /label="purD CDS" gene 634373..635641 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /label="purD gene" downshifts 635626 /Source="Nicolas_upshifts" /id="D320" /incds=0 /nref=140 /ntot=249 /MaxReadThrough="2.77191" /MaxDrop="5.90939" /score="30.0999687" /energy="-11.4" /TU="NA" /idTUdmin="U500" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(635681..636100) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388536.2" /db_xref="EnsemblGenomes-Gn:BSU06540" /db_xref="EnsemblGenomes-Tr:CAB12474" /db_xref="GOA:O31497" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019885" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12874" /db_xref="UniProtKB/Swiss-Prot:O31497" /translation="MDDTDLQILSHLQRNGRLTMVELGKLVGLSSPSAAERVRKLEDK GVITGYSANICYEKLNKHVTAFILMEPKSCKHYAAFATSHPDVAENHRITGMYSYVTK VVTESVHTLEDFIDTSMAHGKPTTLVVLSSSSCHPAF*" /label="yezC CDS" gene complement(635681..636100) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /label="yezC gene" misc_feature complement(636170..636189) /Source="Nicolas_upshift_promotors" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(636179) /Source="Nicolas_upshifts" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="upshifts" CDS 636244..637518 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26319875, 27723097, 24678831; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_388537.2" /db_xref="EnsemblGenomes-Gn:BSU06550" /db_xref="EnsemblGenomes-Tr:CAB12475" /db_xref="GOA:O34560" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12817" /db_xref="UniProtKB/Swiss-Prot:O34560" /translation="MLPELQRSITWIQGTALTIGAVLGCGILILPSVTADTAGPASLF VWVFMSFLSFFLVGTLARLVKIAPSAGGITAYVQLAFQKKAGAILGWIMLGSVPIGVP IIALTGAHYVSYITEAADWQITLIAGCMLAISILLHMRGIQLSANISTLVICVIVFLL VTSIAVSLPHVTIAEFKPFLPHGWSAAGSVSVMIFFSFVGWEMITPLAEEFHRPEKDV PLSLFLAASCVAGLYIMLSFVTVGTHSYGENGEIASLAMLISKGAGESGVYVTVCLAL FITFATIHANIAGFSRMVYALAREGHIPVFFGKLSATKRTPIRVLTAMAAVFGLVLAA HGLFQIDLTTLLKGPSAAFIASYICTMAAALKLLGRRDIGWWMALGAFVACAVIYSFS GWALLYPAVLAAAGYFYMKTKGGHKKKLDHVL*" /label="yecA CDS" gene 636244..637518 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /label="yecA gene" downshifts 637467 /Source="Nicolas_upshifts" /id="D321" /incds=0 /nref=4 /ntot=64 /MaxReadThrough="0.796809999999999" /MaxDrop="2.92696" /score="1.68718502" /energy="-14.2" /TU="NA" /idTUdmin="U498" /TUdmin=1825 /isTUend="FALSE" /label="downshifts" CDS complement(637533..637760) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097691.1" /db_xref="EnsemblGenomes-Gn:BSU06559" /db_xref="EnsemblGenomes-Tr:CAX52578" /db_xref="GOA:C0H3X3" /db_xref="InterPro:IPR021309" /db_xref="UniProtKB/Swiss-Prot:C0H3X3" /translation="MKPNISLINAVFRIACGLTIMSAASAKFTKKPWCRMHLFYIFMG AMKAGSGILRFCPVTYMFQHSDSGNNEHQNG*" /label="yezF CDS" gene complement(637533..637760) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /label="yezF gene" downshifts complement(637544) /Source="Nicolas_upshifts" /id="D322" /incds=0 /nref=29 /ntot=46 /MaxReadThrough="0.14199" /MaxDrop="6.82335" /score="34.1397958" /energy="-13.9" /TU="NA" /idTUdmin="U504" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(637761..638181) /Source="Nicolas_S_feature" /locus_tag="new_713536_713956_c" /HighExp="S8, S7, S5, S6, S4, ferm, nit, BT, Pyr, T5.0H" /AntisenseName="yerA" /AntisenseCor="0.38264258041500998" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S233" promotor_-35 637828..637833 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 637844 /Source="Nicolas_upshifts" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 637847..637866 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 637889..639631 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23109554; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenine deaminase YerA" /protein_id="NP_388538.1" /db_xref="EnsemblGenomes-Gn:BSU06560" /db_xref="EnsemblGenomes-Tr:CAB12476" /db_xref="GOA:O34909" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG12829" /db_xref="UniProtKB/Swiss-Prot:O34909" /translation="MSERTFNWKNKDIRAQVDVVDSKLLPTLLLRNALVLNPYVKQWL KKNIWIYQDRIVYVGHELPNRAEEIHTIDCEGKYIVPGYIEPHAHPFQIYNPQTLAEY VSQYGTTTFVNDNLFLLLQSGKKKALTILNELKKQPVQYFWWSRYDLQTEVLNEDHVL PFDVRKQWIEHPDVIQGGEMTGWPRLVDGDDLMLHCMQATKKQRKRIEGHFPGASDKT LTKMKLFGADCDHEAMTGDEVMRRLELGYYVSLRNSSIRPDVRKILQELHEKGFRYYD HFFYTTDGATPNFYKGGMTNELIRIALEEGVPAIDAYNMASFNIAKYYQMDDYLGVVG PGRLASLNILEDPLNPNPVTVLSKGTILRENGCDLKAFTKTDWHKGGLVPLELSYDMT MDDLQFSMPMGVKMRNAVIMEPYMIEIDNSMEQLSFDHDESYLTMLDRHGKWRVNTMI KGFASSVQGFVSSFTTTGDIVAIGKNKADMLLAFARMKEIGGGIVLAENGNILHEIPL ALCGCASSEAYEDVLEKEQKLRDLLTERGYEFCDPIYTLLFLQSTHLPYIRITPRGIF DVMKKTVLFPSIMR*" /label="yerA CDS" gene 637889..639631 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /label="yerA gene" promotor_-10 complement(638166..638177) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(638181) /Source="Nicolas_upshifts" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(638191..638197) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 638212 /Source="Nicolas_upshifts" /id="D323" /incds=1 /nref=13 /ntot=109 /MaxReadThrough="7.92321" /MaxDrop="3.44855" /score="1.68718502" /energy="-14.2" /TU="U503" /idTUdmin="U498" /TUdmin=2570 /isTUend="FALSE" /label="downshifts" promotor_-35 639605..639611 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 639623 /Source="Nicolas_upshifts" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 639624..639643 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 639658..640653 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12073041; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388539.1" /db_xref="EnsemblGenomes-Gn:BSU06570" /db_xref="EnsemblGenomes-Tr:CAB12477" /db_xref="GOA:O34968" /db_xref="InterPro:IPR021416" /db_xref="InterPro:IPR023158" /db_xref="InterPro:IPR035328" /db_xref="PDB:2PSB" /db_xref="SubtiList:BG12830" /db_xref="UniProtKB/Swiss-Prot:O34968" /translation="MKKWMTVCALCFVFFLLVSCQQKDAVPDTAKKLKAPLTGLKTEQ KVTERRPVAVVVNNHPKARPQSGLSKADIVIEALAEGQITRFLAIFQSQMPETVGPVR SAREYFVTLSNGFDSIFVHHGWSPGAKKQLESGAADYMNGLDFDGSLFWRADFSKPPH NSYTSYDYIKKAAEQKGYKLKQETNPLLFQTSDAKPANESYNVRVDYGTNNVTNLVEY NYDKKAEFYTRSSDGVITTDRETGKPVAMQNIFIVEASHHIIDQDGRRDIDLESGGKG LLFQHGNVIETDWKQVNGRIVPVKDGKWLPFVPGKTWINIVPDLDAASISKGEGV*" /label="yerB CDS" gene 639658..640653 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /label="yerB gene" CDS 640656..640970 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor-histidine operons" /protein_id="NP_388540.1" /db_xref="EnsemblGenomes-Gn:BSU06580" /db_xref="EnsemblGenomes-Tr:CAB12478" /db_xref="GOA:Q7BVT7" /db_xref="InterPro:IPR000831" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013368" /db_xref="SubtiList:BG12831" /db_xref="UniProtKB/Swiss-Prot:Q7BVT7" /translation="MQIDKLRGKELDQLFNSILSLKDLEECYRFFDDLCTINEIQSLA QRLEVARMLREGNTYHKIETETGASTATISRVKRCLNYGNDAYEMALDRVKETETESS SK*" /label="yerC CDS" gene 640656..640970 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /label="yerC gene" downshifts 640833 /Source="Nicolas_upshifts" /id="D324" /incds=1 /nref=1 /ntot=25 /MaxReadThrough="7.1005" /MaxDrop="2.3494" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" downshifts 640975 /Source="Nicolas_upshifts" /id="D325" /incds=0 /nref=78 /ntot=262 /MaxReadThrough="3.58776" /MaxDrop="5.59364" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-232" /isTUend="FALSE" /label="downshifts" CDS complement(641005..642582) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /EC_number="1.4.1.13" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15805528, 17114254, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative osmotic shock glutamate synthase subunit (flavoprotein subunit, ferredoxin-dependent)" /protein_id="NP_388541.1" /db_xref="EnsemblGenomes-Gn:BSU06590" /db_xref="EnsemblGenomes-Tr:CAB12479" /db_xref="GOA:O34849" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024188" /db_xref="InterPro:IPR027283" /db_xref="SubtiList:BG12832" /db_xref="UniProtKB/Swiss-Prot:O34849" /translation="METIIIALIAFIIGIIAIPIVLFAWIYIKDEKQQEHSILRNYPV IGRFRYILEKIGPELRQYLYSNDNEEQPFSRKEYEQTVISGKYKSRMMGFGSVRDFDK PGYYIRNAMFPKQREEMHVNQTPKIETQIYKMDADNLFKRKEHAEHIKADPYFLHPDD VQVIGEHTCEKPFYVKGLVGQSAMSYGSLGERAVTALSKGLHLAGGTWMNTGEGGLSE YHLKGGADIICQIGPGLFGVRKRNGEFSWEEFKRKSRIDQIKAFELKLAQGAKTRGGH VDGAKVSEEVADIRNVEPGKSIDSPNRFYEFSNPPEMLDFIEKLRDVGQKPVGIKLVA GHPEELHELFSHMQKSGKHPDFITIDGSEGGTGASFYELADTVGLPIMTALPIVDTLL KQYGLRSQLKIFASGKLLTPDKIAVALALGADFVNIARGMMFSVGCIRALVCHTNTCP AGVATTDPKLQKALSVEEKQHRVCNYVISLREGLFNLAAAAGINSPIHFSKEHVVYRK EDGSIINIDNLIHQFVS*" /label="yerD CDS" gene complement(641005..642582) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /label="yerD gene" downshifts complement(641019) /Source="Nicolas_upshifts" /id="D326" /incds=0 /nref=7 /ntot=24 /MaxReadThrough="2.99325" /MaxDrop="5.6389" /score="34.8793815" /energy="-15.8" /TU="U506" /idTUdmin="U506" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(642596..642615) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(642615) /Source="Nicolas_upshifts" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(642630..642636) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 642779..642782 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 642796 /Source="Nicolas_upshifts" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 642799..642818 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 642847..643533 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16377641, 21761520, 21214173, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16377641, 21761520, 21214173, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heptaprenylglyceryl-phosphate synthase" /protein_id="NP_388542.1" /db_xref="EnsemblGenomes-Gn:BSU06600" /db_xref="EnsemblGenomes-Tr:CAB12480" /db_xref="GOA:O34790" /db_xref="InterPro:IPR008205" /db_xref="PDB:1VIZ" /db_xref="PDB:3VZX" /db_xref="PDB:3VZY" /db_xref="PDB:3VZZ" /db_xref="PDB:3W00" /db_xref="SubtiList:BG12833" /db_xref="UniProtKB/Swiss-Prot:O34790" /translation="MYDVTEWKHVFKLDPNKDLPDEQLEILCESGTDAVIIGGSDGVT EDNVLRMMSKVRRFLVPCVLEVSAIEAIVPGFDLYFIPSVLNSKNADWIVGMHQKAMK EYGELMSMEEIVAEGYCIANPDCKAAALTEADADLNMDDIVAYARVSELLQLPIFYLE YSGVLGDIEAVKKTKAVLETSTLFYGGGIKDAETAKQYAEHADVIVVGNAVYEDFDRA LKTVAAVKGE*" /label="pcrB CDS" gene 642847..643533 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /label="pcrB gene" CDS 643595..645814 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 12682299, 14594837, 16267290, 26070154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_388543.1" /db_xref="EnsemblGenomes-Gn:BSU06610" /db_xref="EnsemblGenomes-Tr:CAB12481" /db_xref="GOA:O34580" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR005751" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG12834" /db_xref="UniProtKB/Swiss-Prot:O34580" /translation="MNYISNQLLSGLNPVQQEAVKTTDGPLLLMAGAGSGKTRVLTHR IAYLMAEKHVAPWNILAITFTNKAAREMKERVESILGPGADDIWISTFHSMCVRILRR DIDRIGINRNFSILDTADQLSVIKGILKERNLDPKKFDPRSILGTISSAKNELTEPEE FSKVAGGYYDQVVSDVYADYQKKLLKNQSLDFDDLIMTTIKLFDRVPEVLEFYQRKFQ YIHVDEYQDTNRAQYMLVKQLAERFQNLCVVGDSDQSIYRWRGADITNILSFEKDYPN ASVILLEQNYRSTKRILRAANEVIKNNSNRKPKNLWTENDEGIKISYYRGDNEFGEGQ FVAGKIHQLHSTGKRKLSDIAILYRTNAQSRVIEETLLKAGLNYNIVGGTKFYDRKEI KDILAYLRLVSNPDDDISFTRIVNVPKRGVGATSLEKIASYAAINGLSFFQAIQQVDF IGVSAKAANALDSFRQMIENLTNMQDYLSITELTEEILDKTEYREMLKAEKSIEAQSR LENIDEFLSVTKNFEQKSEDKTLVAFLTDLALIADIDQLDQKEEESGGKDAITLMTLH AAKGLEFPVVFLMGLEEGVFPHSRSLMEEAEMEEERRLAYVGITRAEQELYLTNAKMR TLFGRTNMNPESRFIAEIPDDLLENLNEKKETRATSARKMQPRRGPVSRPVSYASKTG GDTLNWAVGDKAGHKKWGTGTVVSVKGEGEGTELDIAFPSPVGVKRLLAAFAPIEKQ* " /label="pcrA CDS" gene 643595..645814 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /label="pcrA gene" CDS 645838..647844 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /EC_number="6.5.1.2" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:164915, 11095673, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 164915, 11095673, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ligase (NAD-dependent)" /protein_id="NP_388544.1" /db_xref="EnsemblGenomes-Gn:BSU06620" /db_xref="EnsemblGenomes-Tr:CAB12482" /db_xref="GOA:O31498" /db_xref="InterPro:IPR001357" /db_xref="InterPro:IPR001679" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004149" /db_xref="InterPro:IPR004150" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013839" /db_xref="InterPro:IPR013840" /db_xref="InterPro:IPR018239" /db_xref="InterPro:IPR033136" /db_xref="InterPro:IPR036420" /db_xref="SubtiList:BG12835" /db_xref="UniProtKB/Swiss-Prot:O31498" /translation="MDKETAKQRAEELRRTINKYSYEYYTLDEPSVPDAEYDRLMQEL IAIEEEHPDLRTPDSPTQRVGGAVLEAFQKVTHGTPMLSLGNAFNADDLRDFDRRVRQ SVGDDVAYNVELKIDGLAVSLRYEDGYFVRGATRGDGTTGEDITENLKTIRNIPLKMN RELSIEVRGEAYMPKRSFEALNEERIKNEEEPFANPRNAAAGSLRQLDPKIAAKRNLD IFVYSIAELDEMGVETQSQGLDFLDELGFKTNQERKKCGSIEEVITLIDELQAKRADL PYEIDGIVIKVDSLDQQEELGFTAKSPRWAIAYKFPAEEVVTKLLDIELNVGRTGVIT PTAILEPVKVAGTTVSRASLHNEDLIKEKDIRILDKVVVKKAGDIIPEVVNVLVDQRT GEEKEFSMPTECPECGSELVRIEGEVALRCINPECPAQIREGLIHFVSRNAMNIDGLG ERVITQLFEENLVRNVADLYKLTKERVIQLERMGEKSTENLISSIQKSKENSLERLLF GLGIRFIGSKAAKTLAMHFESLENLKKASKEELLAVDEIGEKMADAVITYFHKEEMLE LLNELQELGVNTLYKGPKKVKAEDSDSYFAGKTIVLTGKLEELSRNEAKAQIEALGGK LTGSVSKNTDLVIAGEAAGSKLTKAQELNIEVWNEEQLMGELKK*" /label="ligA CDS" gene 645838..647844 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /label="ligA gene" CDS 647860..649050 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388545.1" /db_xref="EnsemblGenomes-Gn:BSU06630" /db_xref="EnsemblGenomes-Tr:CAB12483" /db_xref="GOA:O34629" /db_xref="InterPro:IPR011426" /db_xref="SubtiList:BG12836" /db_xref="UniProtKB/Swiss-Prot:O34629" /translation="MKKTLALAATAAVLMLSACSSGFGGEKEEEITQKTAKSSEKAIV PKYNISDSYYKMVLPFKAGKARGLTTEQLNTRLDIDEFETGLMRLAQDSFSTDDYLFQ EGQYLDEDTVLSWLARKKTGSDLKKAEKEDKNFKNEGLNPALPSSGSTEEKNESSPIY LASMLEHDYLVRKDKNSIQLGGVMIGLALNSVYYYREKTGDPQKEVEIKDSTLRQQGE KIAQEVINRLRKKDNLKNVPITVALYKQASKTSIVPGNFIAKTEVKAGSTDISNWDDI NEKYVFYPADTTTAEKYPDDTEVFKRFKNSIEEYFPNYTGVVGTALYENDEMKKMKID IPMQFYGKSEVVAFTQFLTGEVMDYYSKSSVDVEVNITSSDGQEAVIIRNAGDKEPTV HIYD*" /label="yerH CDS" gene 647860..649050 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /label="yerH gene" misc_feature complement(648055..648059) /Source="Nicolas_upshift_promotors" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(648059) /Source="Nicolas_upshifts" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 649087..649106 /Source="Nicolas_upshift_promotors" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 649095..649211 /Source="Nicolas_S_feature" /locus_tag="new_724870_724986" /HighExp="LoTm, B60, Lbstat, B36, BI, M9-stat, T1.30H, ferm, T3.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S234" upshifts 649095 /Source="Nicolas_upshifts" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(649159) /Source="Nicolas_upshifts" /id="D327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="1.21197" /MaxDrop="3.77048" /score="18.5253059" /energy="-17.7" /TU="NA" /idTUdmin="U511" /TUdmin=1122 /isTUend="FALSE" /label="downshifts" CDS 649212..650222 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase" /protein_id="NP_388546.1" /db_xref="EnsemblGenomes-Gn:BSU06640" /db_xref="EnsemblGenomes-Tr:CAB12484" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG12837" /db_xref="UniProtKB/Swiss-Prot:O34640" /translation="MLDVHKDIKKIFHEEQVLAEAAARYGFSKDQVRFLADAENYVYE CMKDNQPYILKITHTIRRSSDYMMGEMEWLRHLAIGGISVAKPLPSLNGKDVEAVPDG NGGSFLLRVYEKAPGQKVDESDWNETLFYELGRYTGSMHSLTKSYKLSNPAFKRQEWD EEEQLKLRKYVPEDQIKVFQQADSLMNELRRLPKSQDNYGLVHADLHHGNFNWDHGKI TAFDFDDIGYNWFVNDISILLYNVLWYPVVPYDDKAAFTEEFMTHFMKGYWEENELDP AWLMIIPDFLRLRHMLIYGLLHQMFDLNTIGEEEKEMLAGFRRDIENGTPITAFDFSA LV*" /label="yerI CDS" gene 649212..650222 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /label="yerI gene" promotor_no_box complement(649229..649329) /Source="Nicolas_upshift_promotors" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(649269) /Source="Nicolas_upshifts" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 650205 /Source="Nicolas_upshifts" /id="D328" /incds=0 /nref=137 /ntot=253 /MaxReadThrough="3.07041" /MaxDrop="5.10987" /score="12.7441524" /energy="-17" /TU="NA" /idTUdmin="U507" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 650249..651053 /Source="Nicolas_S_feature" /locus_tag="new_726024_726828" /HighExp="B60, B36, LoTm, M9-stat, Cold, T1.30H, T0.30H, ferm, Lbstat, LBGstat" /AntisenseName="sapB" /AntisenseCor="-0.57665624439942198" /AntisenseRegPval="-24.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S235" CDS complement(650260..650958) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 410907, 9043134, 14708580, 27350030, 28181542; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative magnesium transporter" /protein_id="NP_388547.1" /db_xref="EnsemblGenomes-Gn:BSU06650" /db_xref="EnsemblGenomes-Tr:CAB12485" /db_xref="GOA:Q45514" /db_xref="InterPro:IPR003416" /db_xref="SubtiList:BG11845" /db_xref="UniProtKB/Swiss-Prot:Q45514" /translation="MLLSWYIDPDILLKLGIATLIGMVIGLERELKNKPLGLKTCIVI AVSSCMLTIVSINAAYHFPKYYRIMMDPLRLPAQIISGVGFIGAGVILRKSNDVISGL TTSAMIWGAAGLGLATGAGFYKEAFASLLFILISVEFLPWVVRKIGPDRLQEKDIRIR MSLSDKDKMTEILKEMKRRDIKAHSVRIDDLGEKDFPIMEVKVRVHKNRYTTDVYYDI KAIEGVVGVKCDTL*" /label="sapB CDS" gene complement(650260..650958) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /label="sapB gene" downshifts complement(650281) /Source="Nicolas_upshifts" /id="D329" /incds=0 /nref=26 /ntot=129 /MaxReadThrough="2.5379" /MaxDrop="3.83708" /score="20.8493264" /energy="-16.2" /TU="NA" /idTUdmin="U511" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(650978..650996) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(650999) /Source="Nicolas_upshifts" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(651012..651017) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(651065..652543) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline transporter" /protein_id="NP_388548.1" /db_xref="EnsemblGenomes-Gn:BSU06660" /db_xref="EnsemblGenomes-Tr:CAB12486" /db_xref="GOA:O06493" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12641" /db_xref="UniProtKB/Swiss-Prot:O06493" /translation="MSIEIIISLGIYFIAMLLIGWYAFKKTTDINDYMLGGRGLGPFV TALSAGAADMSGWMLMGVPGAMFATGLSTLWLALGLTIGAYSNYLLLAPRLRAYTEAA DDAITIPDFFDKRFQHSSSLLKIVSALIIMIFFTLYTSSGMVSGGRLFESAFGADYKL GLFLTTAVVVLYTLFGGFLAVSLTDFVQGAIMFAALVLVPIVAFTHVGGVAPTFHEID AVNPHLLDIFKGASVISIISYLAWGLGYYGQPHIIVRFMAIKDIKDLKPARRIGMSWM IITVLGSVLTGLIGVAYAHKFGVAVKDPEMIFIIFSKILFHPLITGFLLSAILAAIMS SISSQLLVTASAVTEDLYRSFFRRKASDKELVMIGRLSVLVIAVIAVLLSLNPNSTIL DLVGYAWAGFGSAFGPAILLSLYWKRMNEWGALAAMIVGAATVLIWITTGLAKSTGVY EIIPGFILSMIAGIIVSMITKRPAKASYRLFGVMEKLLKRKK*" /label="opuE CDS" gene complement(651065..652543) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /label="opuE gene" downshifts complement(651079) /Source="Nicolas_upshifts" /id="D330" /incds=0 /nref=43 /ntot=142 /MaxReadThrough="5.35634" /MaxDrop="4.34381" /score="9.43100511" /energy="-13.8" /TU="U512,U513" /idTUdmin="U511" /TUdmin="-798" /isTUend="FALSE" /label="downshifts" upshifts complement(651931) /Source="Nicolas_upshifts" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(651934..651947) /Source="Nicolas_upshift_promotors" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(652544..652674) /Source="Nicolas_S_feature" /locus_tag="new_728319_728449_c" /HighExp="Salt, HiOs, Etha, Gly, MG 25, MG 45, M9-exp, MG t5, MG 15, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.954" /TUlongSig="NA" /TUlongPSig="NA" /label="S236" promotor_-10 complement(652665..652683) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(652674) /Source="Nicolas_upshifts" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(652698..652704) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 652805..652808 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 652823..652956 /Source="Nicolas_S_feature" /locus_tag="new_728598_728731" /HighExp="G180, G150, LBGexp, Oxctl, Paraq, dia0, G135, Lbexp, H2O2, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S237" upshifts 652823 /Source="Nicolas_upshifts" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 652825..652844 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 652957..653247 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9342321, 11445070, 12682299, 25005615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9342321, 11445070, 12682299, 25005615; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit C)" /protein_id="NP_388549.1" /db_xref="EnsemblGenomes-Gn:BSU06670" /db_xref="EnsemblGenomes-Tr:CAB12487" /db_xref="GOA:O06492" /db_xref="InterPro:IPR003837" /db_xref="InterPro:IPR036113" /db_xref="SubtiList:BG12838" /db_xref="UniProtKB/Swiss-Prot:O06492" /translation="MSRISIEEVKHVAHLARLAITEEEAKMFTEQLDSIISFAEELNE VNTDNVEPTTHVLKMKNVMREDEAGKGLPVEDVMKNAPDHKDGYIRVPSILD*" /label="gatC CDS" gene 652957..653247 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /label="gatC gene" CDS 653263..654720 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit A)" /protein_id="NP_388550.1" /db_xref="EnsemblGenomes-Gn:BSU06680" /db_xref="EnsemblGenomes-Tr:CAB12488" /db_xref="GOA:O06491" /db_xref="InterPro:IPR000120" /db_xref="InterPro:IPR004412" /db_xref="InterPro:IPR020556" /db_xref="InterPro:IPR023631" /db_xref="InterPro:IPR036928" /db_xref="SubtiList:BG12839" /db_xref="UniProtKB/Swiss-Prot:O06491" /translation="MSLFDHKITELKQLIHKKEIKISDLVDESYKRIQAVDDKVQAFL ALDEERARAYAKELDEAVDGRSEHGLLFGMPIGVKDNIVTKGLRTTCSSKILENFDPI YDATVVQRLQDAEAVTIGKLNMDEFAMGSSTENSAYKLTKNPWNLDTVPGGSSGGSAA AVAAGEVPFSLGSDTGGSIRQPASFCGVVGLKPTYGRVSRYGLVAFASSLDQIGPITR TVEDNAFLLQAISGVDKMDSTSANVDVPDFLSSLTGDIKGLKIAVPKEYLGEGVGKEA RESVLAALKVLEGLGATWEEVSLPHSKYALATYYLLSSSEASANLARFDGIRYGYRTD NADNLIDLYKQTRAEGFGNEVKRRIMLGTFALSSGYYDAYYKKAQKVRTLIKKDFEDV FEKYDVIVGPTTPTPAFKIGENTKDPLTMYANDILTIPVNLAGVPGISVPCGLADGLP LGLQIIGKHFDESTVYRVAHAFEQATDHHKAKPEL*" /label="gatA CDS" gene 653263..654720 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /label="gatA gene" CDS 654734..656164 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit B)" /protein_id="NP_388551.2" /db_xref="EnsemblGenomes-Gn:BSU06690" /db_xref="EnsemblGenomes-Tr:CAB12489" /db_xref="GOA:O30509" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR004413" /db_xref="InterPro:IPR006075" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR017958" /db_xref="InterPro:IPR017959" /db_xref="InterPro:IPR018027" /db_xref="InterPro:IPR023168" /db_xref="SubtiList:BG12840" /db_xref="UniProtKB/Swiss-Prot:O30509" /translation="MNFETVIGLEVHVELKTKSKIFSSSPTPFGAEANTQTSVIDLGY PGVLPVLNKEAVEFAMKAAMALNCEIATDTKFDRKNYFYPDNPKAYQISQFDKPIGEN GWIEIEVGGKTKRIGITRLHLEEDAGKLTHTGDGYSLVDFNRQGTPLVEIVSEPDIRT PEEAYAYLEKLKSIIQYTGVSDCKMEEGSLRCDANISLRPIGQEEFGTKTELKNLNSF AFVQKGLEHEEKRQEQVLLSGGVIQQETRRYDEATKKTILMRVKEGSDDYRYFPEPDL VELYIDDEWKERVKASIPELPDERRKRYIEELGLPAYDAMVLTLTKEMADFFEETVQK GAEAKQASNWLMGEVSAYLNAEQKELADVALTPEGLAGMIKLIEKGTISSKIAKKVFK ELIEKGGDAEKIVKEKGLVQISDEGVLLKLVTEALDNNPQSIEDFKNGKDRAIGFLVG QIMKASKGQANPPMVNKILLEEIKKR*" /label="gatB CDS" gene 654734..656164 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /label="gatB gene" downshifts 656145 /Source="Nicolas_upshifts" /id="D331" /incds=0 /nref=257 /ntot=266 /MaxReadThrough="1.62334" /MaxDrop="8.77378" /score="26.1218607" /energy="-9.6" /TU="NA" /idTUdmin="U514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(656179..657048) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388552.1" /db_xref="EnsemblGenomes-Gn:BSU06700" /db_xref="EnsemblGenomes-Tr:CAB12490" /db_xref="GOA:O31500" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG12841" /db_xref="UniProtKB/Swiss-Prot:O31500" /translation="MNEKKERIIKTSIRLFAKKGFAATTIQEIASECGISKGAFYLHF KSKEALLLSACEYYIGMSMNKMKNIEEDLAGKPPKEVLKKQIGAQFEDFRDHKDFIVL LLTENIIPENQEIKQYFYKVTMETDKLYRNALLVSYGEGIERYVADLSIMARGIVHSY MNVMVFNGELNIDAEEISAFIIERLDDLVQGLSRSALNPIVSKDIFNPMPAGKDQLLE DIQKVKENSTLPEDITVSLDVIEEELTQDKPRKPIIKGMLSNLAGTNDKEVERLRALI LSLSQFDHKKSSL*" /label="yerO CDS" gene complement(656179..657048) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /label="yerO gene" downshifts complement(656221) /Source="Nicolas_upshifts" /id="D332" /incds=0 /nref=122 /ntot=211 /MaxReadThrough="2.21801" /MaxDrop="4.89305" /score="32.2694333" /energy="-11.4" /TU="NA" /idTUdmin="U517" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 656838..656843 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-35" promotor_-10 656859..656877 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-10" upshifts 656871 /Source="Nicolas_upshifts" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="upshifts" S_feature complement(657049..657123) /Source="Nicolas_S_feature" /locus_tag="new_732824_732898_c" /HighExp="C30, S1, T3.0H, T4.0H, Salt, T5.0H, T2.0H, T3.30H, MG 150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S238" promotor_-35 657101..657108 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(657117..657136) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 657123 /Source="Nicolas_upshifts" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 657124..657143 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(657130) /Source="Nicolas_upshifts" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(657151..657158) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-35" CDS 657180..660338 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11709341, 15066026, 15941986, 25366377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11709341, 15066026, 15941986, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter involved in surfactin self-resistance" /protein_id="NP_388553.2" /db_xref="EnsemblGenomes-Gn:BSU06710" /db_xref="EnsemblGenomes-Tr:CAB12491" /db_xref="GOA:O31501" /db_xref="InterPro:IPR001036" /db_xref="InterPro:IPR027463" /db_xref="SubtiList:BG12842" /db_xref="UniProtKB/Swiss-Prot:O31501" /translation="MNHVINFVLKNKFAVWLMTIIVTAAGLYAGMNMKQESIPDVNMP YLTISTTYPGATPSQVADEVTKPVEQAVQNLDGVSVVTSTSYENASSVMIEYDYEKDM DKAKTEAAEALENVNLPDDAKDPEISRYSLNSFPILTLSVSSDKDNLQELTKQVEDSL VSKLEGIEGVASVQVSGQQVEEVEFSFKEDKLKEYGLDEDTVKQVIQGSDVTTPLGLY TFGNEEKSVVVSGDIETIKDLKNMRIPTASASSAGSSAASQAGAQSAQAAQSAQAAAQ VQQSASTAVPTVKLSDIATIKDVKKAESVSRTNGKDSIGINIVKANDANTVEVADDVK AELKKFKEDHKGFNYSATLDMAEPITQSVDTMLSKAIFGAIFAIVIILLFLRDIKSTL ISVVSIPLSLLIALLVLQQLDITLNIMTLGAMTVAIGRVVDDSIVVIENIYRRMRLKD EPLRGKALVREATKEMFKPIMSSTIVTIAVFLPLALVGGQIGELFIPFALTIVFALAA SLVISITLVPMLAHSLFKKSLTGAPIKAKEHKPGRLANIYKKVLNWALSHKWITSIIA VLMLLGSLFLVPLIGASYLPSEEEKTMQLTYSPEPGETKKEAENEAEKAEKILLDRKH VDTVQYSLGSGSPLAGGDSNGALFYIKYESDTPDFDKEKDNVLKEIQKQSDRGEWKSQ DFSSSGNNNELTYYVYGDSENDIKDTVKDIEKIMKDEKDLKNVNSGLSSTYDEYTFVA DQEKLSKLGLTASQISQALMSQTSQEPLTTVKKDGKELDVNIKTEKDEYKSVKDLENK KITSATGQEVKIGDVAKVKEGSTSDTVSKRDGKVYADVTGEVTSDNVTAVSAAIQKKI DKLDHPDNVSIDTGGVSADIADSFTKLGLAMLAAIAIVYLVLVITFGGALAPFAILFS LPFTVIGALVGLYVSGETISLNAMIGMLMLIGIVVTNAIVLIDRVIHKEAEGLSTREA LLEAGSTRLRPILMTAIATIGALIPLALGFEGGSQVISKGLGVTVIGGLISSTLLTLL IVPIVYEVLAKFRKKKPGTEEE*" /label="srfP CDS" gene 657180..660338 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /label="srfP gene" downshifts 660325 /Source="Nicolas_upshifts" /id="D333" /incds=0 /nref=76 /ntot=243 /MaxReadThrough="3.70478" /MaxDrop="4.6624" /score="-3.65521193" /energy="-12.7" /TU="U516" /idTUdmin="U516" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_-35 660577..660580 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 660595..660614 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 660603 /Source="Nicolas_upshifts" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="upshifts" CDS 660661..661572 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /EC_number="2.7.1.107" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12682299, 17535816, 22224599, 24700682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12682299, 17535816, 22224599, 24700682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diacylglycerol kinase" /protein_id="NP_388554.1" /db_xref="EnsemblGenomes-Gn:BSU06720" /db_xref="EnsemblGenomes-Tr:CAB12492" /db_xref="GOA:O31502" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG12843" /db_xref="UniProtKB/Swiss-Prot:O31502" /translation="MKRARIIYNPTSGREIFKKHLAQVLQKFEQAGYETSTHATTCAG DATHAAKEAALREFDLIIAAGGDGTINEVVNGLAPLDNRPTLGVIPVGTTNDFARALG IPREDILKAADTVINGVARPIDIGQVNGQYFINIAGGGRLTELTYDVPSKLKTMLGQL AYYLKGMEMLPSLRPTEVEIEYDGKLFQGEIMLFLVTLTNSVGGFEKLAPDSSLNDGM FDLMILKKANLAEFIRVATMALRGEHINDQHIIYTKANRVKVNVSEKMQLNLDGEYGG MLPGEFVNLYRHIHVVMPKEKAEQLDD*" /label="dagK CDS" gene 660661..661572 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /label="dagK gene" S_feature 661573..661827 /Source="Nicolas_S_feature" /locus_tag="new_737348_737602" /HighExp="H2O2, Oxctl, Paraq, G180, Cold, C30, G150, G135, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S239" CDS 661828..663207 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /EC_number="2.1.1.189" /EC_number="2.1.1.190" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21824914" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21824914; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyltransferase of m5U747 and m5U1939 in 23S RNA" /protein_id="NP_388555.1" /db_xref="EnsemblGenomes-Gn:BSU06730" /db_xref="EnsemblGenomes-Tr:CAB12493" /db_xref="GOA:O31503" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12826" /db_xref="UniProtKB/Swiss-Prot:O31503" /translation="MKMKPPVEKNEYYDVTFEDLTHEGAGVAKVQGFPIFVPNALPEE KAQIKVTRVKKGFAFGRLIELKEESPHRTDAPCPIYKQCGGCQLQHMTYEGQLLFKQK QVKDVLERIGKLDLSKVTVHPTLGMEDPWNYRNKAQVPVGEREGGLVAGFYQQRSHDI IDMSACLIQQSKNDEAVQAVKDICANYGVKAYNEERHKGWLRHIMVRYGVVTGEMMIV FITRTSDFPHKAKIIEDITAQFPHVKSIVQNINPNKTNVIFGNETNVIWGEEYIYDLI GDVKFAISARSFYQVNPEQTKVLYDKALEYAELQGEETVIDAYCGIGTISLFLAKQAK KVYGVEIVPEAIEDAKRNAELNGNTNAEFAVGEAETVIPKWYEEGITADTLVVDPPRK GCDEALLRTIVEMKPKRVVYVSCNPGTLARDLRVLEDGGYVTREVQPVDMFPHTNHVE CCVLIKLKE*" /label="rlmCD CDS" gene 661828..663207 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /label="rlmCD gene" S_feature 663208..663800 /Source="Nicolas_S_feature" /locus_tag="new_738983_739575" /HighExp="Cold, H2O2, G135, G150, Oxctl, G180, C30, Paraq, LPh, HPh" /AntisenseName="yefB" /AntisenseCor="0.24913678485492899" /AntisenseRegPval="-4.4000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S240" CDS complement(663220..664122) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1779754, 1762151; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase / invertase; HGT island" /protein_id="NP_388556.1" /db_xref="EnsemblGenomes-Gn:BSU06740" /db_xref="EnsemblGenomes-Tr:CAB12494" /db_xref="GOA:O34574" /db_xref="InterPro:IPR011109" /db_xref="InterPro:IPR025827" /db_xref="SubtiList:BG12827" /db_xref="UniProtKB/Swiss-Prot:O34574" /translation="MYNEGVTSPSQLARKKNATDKWHGSSIRKILENPHYTGTLQQCR EYRPSVTSKRRRSVNLENQIIIEKSHEPIIPLEDFLIVQEILITRKRRRPQAEVHLFT NTAVCKDCRRSMHFKKNRKGYVCGSYNKHGLKACSDHYVSEIDLTDKVITNLNKIYLK FSKENYFKELSEKALKYKEKIESKIIEINEKLNDKKRDKSNLVISLANGVISKEDYQL AINITNEDISNFETTLHQLSKDLEFQKIEKEIIDFKKSLDKFMKEGTLTPEMLHLLVD EIEVHANGTIEINYRFREPTVPSA*" /label="yefB CDS" gene complement(663220..664122) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" /label="yefB gene" downshifts 663757 /Source="Nicolas_upshifts" /id="D334" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="4.70474" /MaxDrop="2.82299" /score="-8.81916201" /energy="-8.8" /TU="U518" /idTUdmin="U516" /TUdmin=3322 /isTUend="FALSE" /label="downshifts" S_feature 663802..664102 /Source="Nicolas_S_feature" /locus_tag="new_739577_739877" /HighExp="H2O2, Cold, G180, G135, G150, Paraq, Oxctl, C30, LPh, LBGexp" /AntisenseName="yefB" /AntisenseCor="0.202214664414261" /AntisenseRegPval="-3.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S241" CDS 664103..664438 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative resolvase; HGT island" /protein_id="NP_388557.2" /db_xref="EnsemblGenomes-Gn:BSU06750" /db_xref="EnsemblGenomes-Tr:CAB12495" /db_xref="GOA:O35034" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG12828" /db_xref="UniProtKB/Swiss-Prot:O35034" /translation="MTPSLYNPLAIASKPFPAIYSEKILIFTIFSAFAEFERDMIVER TQEGKMLAKQNPDFREGRPKKFTKQQINHALTLLENHSYKQVEDMTGISVSTLVRAKK KKAAEAING*" /label="yefC CDS" gene 664103..664438 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" /label="yefC gene" S_feature 664439..664512 /Source="Nicolas_S_feature" /locus_tag="new_740214_740287" /HighExp="G180, H2O2, G150, Cold, G135, Paraq, Oxctl, C30, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S242" CDS 664513..667152 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative restriction type II methylase; HGT island" /protein_id="NP_388558.1" /db_xref="EnsemblGenomes-Gn:BSU06760" /db_xref="EnsemblGenomes-Tr:CAB12496" /db_xref="GOA:O31504" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12818" /db_xref="UniProtKB/Swiss-Prot:O31504" /translation="MALIDLEDKIAEIVNREDHSDFLYELLGVYDVPRATITRLKKGN QNLTKRVGEVHLKNKVWFKEAKKGKLFDALIDIEQQVEYLSAKPRYLLVTDYDGVLAK DTKTLEALDVKFEELPQYFDFFLAWKGIEKVEFEKENPADIKAAERFARIYDVLRKEN NIIETNRGLDLFLIRLLFCFFAEDTDIFKRNSFTNLIKTLTEEDGSNLNKLFADLFIV LDKNERDDVPSYLKEFPYVNGQLFTEPHTELEFSAKSRKLIIECGELLNWAKINPDIF GSMIQAVASEESRSYLGMHYTSVPNIMKVIKPLFLDKLNQSFLDAYDDYTKLENLLTR IGKIKFFDPACGSGNFLIITYKELRRMEINIIKRLQELLGEYLYVPSVTLSQFYGIEI EDFAHDVAKLSLWIAEHQMNEELKNEVHNAVRPTLPLHTAGDIRCANAIRVEWTEVCP AQGSEEVYVFGNPPYLGSKKQNKEHKSDMLSIFGKVKNGKMLDYISAWFYFGAKYAST TNAKVAFVSTNSVTQGEQVSILWNELFKFGIQINFAYKSFKWANNAKNNAAVIVVIVG FGPLDTKVNKYLFVDETKKLVSNISPYLTDGENILVSSRTKPISDLPKLHFGNMPNDG GGLLFTITEYTDAINKYPELVPYFKKFIGSVEFINGGLRYCLWLNEAKYEKIKSNPLI QERISISKNHREKSTDKGTNKLALTPWKFRDTHETTNYSIVVPSVSSENRFYIPMGLA GADTILSNLIYVIYDAEIYLLGILMSRMHMTWVKAVAGRLKTDYRYSAGLCYNTFPIP ELSTRRKNEIEEAILEILDLREEQGGTLAELYNPSTMPIELKVAHEKLDGIVERAYRQ KQFESDEERLEVLLKLYQEMTER*" /label="yeeA CDS" gene 664513..667152 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" /label="yeeA gene" CDS 667164..668963 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA helicase / endonuclease; HGT island" /protein_id="NP_388559.2" /db_xref="EnsemblGenomes-Gn:BSU06770" /db_xref="EnsemblGenomes-Tr:CAB12497" /db_xref="GOA:O34469" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12819" /db_xref="UniProtKB/Swiss-Prot:O34469" /translation="MENIIEINYNQTGKSKKTNEYGMREMQARAFEKRNSQYLLVKAP PASGKSRALMFIGLDKLINQGLRKVIVAVPERSIGSSFKNTDLKSYGFFENWKVDPRN NLTVGGDNSKVKSFVRFMESDDQVLICTHSTLRFAFEKIDDKAFDNCLLAIDEFHHVS ADVNSRLGELLRSIIHNSSAHIVAMTGSYFRGDSVPILLPEDEELFDKVTYSYYEQLD GYEYLKGFGIGYHFYQGQYTSAINEVLDTNKKTIVHIPNVNSGESTKDKYDEVGKILD MIGEVEYQDDDTGIIYVKRHSDGKTLKIADLVDDQVGRENVVAYLRNIEALDDLDIII ALGMAKEGFDWPFCEHTLTVGYRGSLTEIVQIIGRCTRDSYNKTYAQFTNLIAMPDAK DEVVTYTVNTMLKAISASLLMEQVLTPDFKFKRRRNESEKSSTTGELFVKGLKEPSTE NVKKIIENDINDLKAKIMQDSQVQKTFSGEVDPKVLNKVLIPKVIQKVYPNLSDEEIE EVRQHVVLDTVMKGAKSEVVGSKEFIRMADKFINIEDLDINLIDSINPFQKAFEVLSK ELNSPVLKLIQETIDAKRINFDEDELVFIWPKV*" /label="yeeB CDS" gene 667164..668963 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" /label="yeeB gene" promotor_-10 complement(667404..667419) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(667419) /Source="Nicolas_upshifts" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(667431..667440) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 668964..669075 /Source="Nicolas_S_feature" /locus_tag="new_744739_744850" /HighExp="Cold, G180, G135, G150, H2O2, Paraq, HPh, LPh, Oxctl, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S243" CDS 669076..670224 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388560.2" /db_xref="EnsemblGenomes-Gn:BSU06780" /db_xref="EnsemblGenomes-Tr:CAB12498" /db_xref="InterPro:IPR018306" /db_xref="SubtiList:BG12820" /db_xref="UniProtKB/Swiss-Prot:O34352" /translation="MASNRYHSINEIMESQLFYQITTPPKKTQKAQYDPEVEKFLEII EFVKENGREPQKVPTDLTERSLASRLIGIRKDPDRMEYLKEYDEIGLLEVRSKELTIP KISSIDDILKSGLSALLGDNLNNDITRSIFDTSSLQKVTTMPEYVAKRKKIKDFGKFE ELFKKCHKEITEGKRKILTFKNEQDIQSNSFYILKGVLLYVEDVGERKKAKGKTNARL RCIFENGTESDMLLRSLSAELYKHGRRVTDNEDTLLDNVREDDVSTGFIYVLKSLSTD PQISSIKNLYKIGFTTGSVENRIRNAENQSTYLYAPVEIVTTYQVFNMNASKFETAIH HALANNNLDVSILGANGKMLVPKEWFVVTLEDLQAVIDEIVMMVHLYD*" /label="yeeC CDS" gene 669076..670224 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" /label="yeeC gene" S_feature 670225..671414 /Source="Nicolas_S_feature" /locus_tag="new_746000_747189" /HighExp="Cold, G135, H2O2, G180, G150, LPh, C30, HPh, BMM, Paraq" /AntisenseName="yeeD" /AntisenseCor="-0.41772847620445203" /AntisenseRegPval="-12.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S244" CDS complement(670486..670791) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388561.1" /db_xref="EnsemblGenomes-Gn:BSU06790" /db_xref="EnsemblGenomes-Tr:CAB12499" /db_xref="SubtiList:BG12821" /db_xref="UniProtKB/Swiss-Prot:O34950" /translation="MTVRKELIKQINLTITVIKTINQKNPTPMVKNILKRYEEAKEFI LQSSDGKFEEDLSKVRNKLDTLTRAYLESANDYMNPMLKEMHKTEKLLKEYDETTQS* " /label="yeeD CDS" gene complement(670486..670791) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" /label="yeeD gene" CDS complement(670858..671064) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="hypothetical protein; HGT island" /protein_id="NP_388562.1" /db_xref="EnsemblGenomes-Gn:BSU06800" /db_xref="EnsemblGenomes-Tr:CAB12500" /db_xref="GOA:O31505" /db_xref="InterPro:IPR000290" /db_xref="InterPro:IPR035900" /db_xref="SubtiList:BG12872" /db_xref="UniProtKB/Swiss-Prot:O31505" /translation="MDKLTKEELIFLVKELMNPTLDDEKVSEYLDLLEKNVPYPAPSD LIFWSNEDYTAEQVVKIALNYKDE*" /label="yezA CDS" gene complement(670858..671064) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" /label="yezA gene" CDS complement(671304..671759) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="YP_003097692.1" /db_xref="EnsemblGenomes-Gn:BSU06811" /db_xref="EnsemblGenomes-Tr:CAX52579" /db_xref="InterPro:IPR006728" /db_xref="InterPro:IPR036170" /db_xref="UniProtKB/Swiss-Prot:C0H3X4" /translation="MQDLYQLIGEKLNDIIPGEWTKIYLYAEVLDDSTMVLFHFRTPE NNQIIYSQDIPSHYNVSKDIFKTLLRELRELFEELRTEHRNNNDDVWTNLTLTLDRSG EFQLDYNYDDILASELDGYERIAIWEYKNLGILPEDEDDKEFVISYLGL*" /label="yezG CDS" gene complement(671304..671759) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" /label="yezG gene" downshifts complement(671317) /Source="Nicolas_upshifts" /id="D335" /incds=0 /nref=41 /ntot=213 /MaxReadThrough="4.42275" /MaxDrop="5.23695" /score="10.2582155" /energy="-11.7" /TU="U520,U521" /idTUdmin="U520" /TUdmin="-529" /isTUend="FALSE" /label="downshifts" CDS complement(671779..673788) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein; HGT island" /protein_id="NP_388563.2" /db_xref="EnsemblGenomes-Gn:BSU06812" /db_xref="EnsemblGenomes-Tr:CAB12501" /db_xref="GOA:O31506" /db_xref="InterPro:IPR006829" /db_xref="SubtiList:BG12822" /db_xref="UniProtKB/Swiss-Prot:O31506" /translation="MKVFEAKTLLSEATDRAKEYKELRTQMVNLRKALKGVADLSDSE FSGKGASNIKAFYHDHVGVADQWIDYIDMKIAFFNSIAGAAEDKGLSDAYIEESFLEH ELANANKKSKSIMSEQKKAMKDILNDIDDILPLDLFSTETFKDELADANDKRKKTLEK LDALDEDLKTEYALSEPNEQFIKSDFQKLQEATGKGKNATPIHYNAKAYRESDIHKKK GDIEKRTEAYLKIKKEEAKEREIEKLKERLKNYDYADADEFYEMAKTIGYENLTAEQQ RYFTQIENTRELEAGFKGVAVGLYDSGKDAVVGLWDMVTDPGGTVEAITGAMAHPIKT YEAISAAIEESYQKDMVNGDTYSRARWVSYAVGTVVTSIVGTKGVGAVSKTGTAAKVT TKVKTAASKSATAQKAITVSKQTVDHIKQKVNTGIEVSKKHVKTKLNQIGDLTLADIL PYHPRHDLVPAGVPYNAVNGVTLKEGLQKFAKVILPKPYGTSSSGRRTPAPHVPPVTV KYGEHFARWSRKKVLKPNIIYKTKEGYTYTTDNYGRITSVKADLQLGEAKRNQYAQTN AGKPQDRKPDDDGGHLIATQFKGSGQFDNIVPMNSQINRSGGKWYEMEQEWAKALSKK PPKKVAVQIEPVYSGDSLRPSYFDVTYKIGSRKEISVSIKNQPGG*" /label="yeeF CDS" gene complement(671779..673788) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" /label="yeeF gene" promotor_-10 complement(672146..672165) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(672153) /Source="Nicolas_upshifts" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(672178..672183) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(673815..673834) /Source="Nicolas_upshift_promotors" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(673825) /Source="Nicolas_upshifts" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" /label="upshifts" CDS 674000..675022 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage receptor protein" /protein_id="NP_388564.2" /db_xref="EnsemblGenomes-Gn:BSU06820" /db_xref="EnsemblGenomes-Tr:CAB12502" /db_xref="GOA:O31507" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12823" /db_xref="UniProtKB/Swiss-Prot:O31507" /translation="MTKKRITFGLLVLMVCVILFVLYVQLRNKDSIPVQSSAIHPEED RIFFIYSNPFIKESVLLSTSTGERFNRRTFKVADVPYIQTKSYASTDLVLLAEHEPFY YTLEKDVIKEHPLSDPFAFWYEGKDVTIEAYNVDTTGNEIHINDRKTKKEYTLTLPPL VTMGASDENFIYIIQSMSIYVIDRKTEEMIETLSLASYADQFADSEEFIVASSDHKLT VIEKGTWKTTYIAYPEDLEYADTVYYDKESGSFYVAYEDKEGGANLLEYGEDFSIHTY SLKFPYMEAKFKGNLLYIVAQEEHKKGIGGYVGVFDIHSKEMLYQFDLPEEQVKVQDF VVVDNK*" /label="yeeG CDS" gene 674000..675022 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" /label="yeeG gene" promotor_-35 675122..675129 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-35" promotor_-10 675143..675162 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-10" upshifts 675144 /Source="Nicolas_upshifts" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="upshifts" CDS 675184..676314 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388565.2" /db_xref="EnsemblGenomes-Gn:BSU06830" /db_xref="EnsemblGenomes-Tr:CAB12503" /db_xref="GOA:Q59HN8" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG11031" /db_xref="UniProtKB/Swiss-Prot:Q59HN8" /translation="MSQAIPSSRVGVKINEWYKMIRQFSVPDAEILKAEVEQDIQQME EDQDLLIYYSLMCFRHQLMLDYLEPGKTYGNRPTVTELLETIETPQKKLTGLLKYYSL FFRGMYEFDQKEYVEAIGYYREAEKELPFVSDDIEKAEFHFKVAEAYYHMKQTHVSMY HILQALDIYQNHPLYSIRTIQSLFVIAGNYDDFKHYDKALPHLEAALELAMDIQNDRF IAISLLNIANSYDRSGDDQMAVEHFQKAAKVSREKVPDLLPKVLFGLSWTLCKAGQTQ KAFQFIEEGLDHITARSHKFYKELFLFLQAVYKETVDERKIHDLLSYFEKKNLHAYIE ACARSAAAVFESSCHFEQAAAFYRKVLKAQEDILKGECLYAY*" /label="rapH CDS" gene 675184..676314 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" /label="rapH gene" CDS 676304..676477 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type r: regulator" /codon_start=1 /transl_table=11 /product="hexapeptide (TDRNTT) inhibitor of regulatory cascade" /protein_id="YP_003097693.1" /db_xref="EnsemblGenomes-Gn:BSU06839" /db_xref="EnsemblGenomes-Tr:CAX52580" /db_xref="GOA:Q59HN7" /db_xref="UniProtKB/Swiss-Prot:Q59HN7" /translation="MPIKKKVMMCLAVTLVFGSMSFPTLTNSGGFKESTDRNTTYIDH SPYKLSDQKKALS*" /label="phrH CDS" gene 676304..676477 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" /label="phrH gene" downshifts 676432 /Source="Nicolas_upshifts" /id="D336" /incds=0 /nref=3 /ntot=66 /MaxReadThrough="5.5891" /MaxDrop="2.9063" /score="14.5772672" /energy="-7.6" /TU="U522" /idTUdmin="U522" /TUdmin="-901" /isTUend="FALSE" /label="downshifts" S_feature 676478..676582 /Source="Nicolas_S_feature" /locus_tag="new_752253_752357" /HighExp="S2, G/S, T2.30H, GM 150, T3.0H, T2.0H, S1, T-4.40H, T-2.40H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S245" promotor_-35 676549..676556 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 676571..676590 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 676584 /Source="Nicolas_upshifts" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="upshifts" CDS 676637..677356 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA integrase or transcriptional regulator" /protein_id="NP_388566.3" /db_xref="EnsemblGenomes-Gn:BSU06840" /db_xref="EnsemblGenomes-Tr:CAB12504" /db_xref="GOA:O31509" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026562" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG12824" /db_xref="UniProtKB/Swiss-Prot:O31509" /translation="MGRKWNNIKEKKASKDANTSRIYAKFGREIYVAAKQGEPDPESN QALKVVLERAKTYSVPKNIIERAIEKAKGGAEENYDELRYEGFGPNGSMIIVDALTNN VNRTAPEVRAAFGKNGGNMGVSGSVAYMFDATAVIGVEGKTADEALEILMEADVDVRD ILEEDDSAIVYAEPDQFHAVQEAFKNAGVEEFTVAELTMLAQSEVTLPDDAKEQFEKL IDALEDLEDVQQVYHNVDLGE*" /label="yeeI CDS" gene 676637..677356 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" /label="yeeI gene" downshifts complement(676639) /Source="Nicolas_upshifts" /id="D337" /incds=0 /nref=3 /ntot=70 /MaxReadThrough="1.42969" /MaxDrop="3.99424" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-5851" /isTUend="FALSE" /label="downshifts" promotor_-35 677214..677221 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 677235..677254 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 677245 /Source="Nicolas_upshifts" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="upshifts" downshifts 677338 /Source="Nicolas_upshifts" /id="D338" /incds=0 /nref=223 /ntot=271 /MaxReadThrough="4.94236" /MaxDrop="5.19148" /score="31.0415099" /energy="-11.4" /TU="U523,U524" /idTUdmin="U522" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-35 677425..677434 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 677448..677467 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 677451 /Source="Nicolas_upshifts" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(677455..677473) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(677475) /Source="Nicolas_upshifts" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(677489..677494) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 677490..677927 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 19060142, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 19060142, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore inner coat protein" /protein_id="NP_388567.2" /db_xref="EnsemblGenomes-Gn:BSU06850" /db_xref="EnsemblGenomes-Tr:CAB12505" /db_xref="GOA:O31510" /db_xref="SubtiList:BG12825" /db_xref="UniProtKB/Swiss-Prot:O31510" /translation="MTDTRHMYGGPGFGHYQGFGIGHPGYGMQSTGYPGYGMYGGHPG YGMQGYPDHGIHGGVGGYPGYGGYGGYPSGGYGGSPGTGSYPSMHHENDGHHHYYHHH HDGKDNLHHHHHHVGKDNHHHHHDGHYGHHHHHMGHWGKDGYK*" /label="cotK CDS" gene 677490..677927 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" /label="cotK gene" downshifts complement(677497) /Source="Nicolas_upshifts" /id="D339" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.62645" /MaxDrop="3.26146" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-6709" /isTUend="FALSE" /label="downshifts" downshifts 677927 /Source="Nicolas_upshifts" /id="D340" /incds=0 /nref=82 /ntot=208 /MaxReadThrough="2.37564" /MaxDrop="8.21113" /score="17.7046271" /energy="-9" /TU="U525" /idTUdmin="U523" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 677987..677994 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 678010..678029 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 678015 /Source="Nicolas_upshifts" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="upshifts" CDS 678042..678626 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR family)" /protein_id="YP_054572.1" /db_xref="EnsemblGenomes-Gn:BSU06860" /db_xref="EnsemblGenomes-Tr:CAE01448" /db_xref="GOA:Q7WY76" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14194" /db_xref="UniProtKB/Swiss-Prot:Q7WY76" /translation="MGRNKEFDTALVLHRAIEVFGEYGYEGTSLQDLLSHLGIARQSL YDTYGTKRDLFLSAVKSYLEGKNAAVMERLEAPGSVKEAIRDIFQEGVNALRDPERAK ACYIINSAIEQIPHDPELARYFERQSKQLEDAFYHGLLRAKDQGELNGEDTDISALAR YLNQSRLSLTFIAKVTADMDRLQDHVDVSLSVLD*" /label="yezE CDS" gene 678042..678626 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" /label="yezE gene" downshifts 678607 /Source="Nicolas_upshifts" /id="D341" /incds=0 /nref=26 /ntot=216 /MaxReadThrough="2.43615" /MaxDrop="3.31193" /score="17.7046271" /energy="-9" /TU="NA" /idTUdmin="U527" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS 678705..679148 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388568.1" /db_xref="EnsemblGenomes-Gn:BSU06870" /db_xref="EnsemblGenomes-Tr:CAB12506" /db_xref="InterPro:IPR009959" /db_xref="InterPro:IPR032710" /db_xref="PDB:1S5A" /db_xref="SubtiList:BG12844" /db_xref="UniProtKB/Swiss-Prot:O31511" /translation="MLMNEFEKACETLRKFMAYMLEKDMKSWTELWDENAVFEFPYAP EGSPKRIEGKAAIYDYIKDYPKQIHLSSFTAPTVYRSADSNTVIAEFQCDGHVIETGL PYRQSYISVIETRDGRIVRYRDYWNPLVVKEAFGGSFLQTEESGK*" /label="yesE CDS" gene 678705..679148 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" /label="yesE gene" CDS 679145..680005 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21494745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388569.1" /db_xref="EnsemblGenomes-Gn:BSU06880" /db_xref="EnsemblGenomes-Tr:CAB12507" /db_xref="GOA:O31512" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR008030" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11808" /db_xref="UniProtKB/Swiss-Prot:O31512" /translation="MMKQNPILITGGTGTVGSRIASRLIKLGYRVRIASRKKGALADA EYVYFNWKYASSFTPALEQVKQIYLVAPVGVFDPAPYVLPFLKEAKRLGAKRVVMQSA SVVSENGPVFGALHQAVREFPEWTVLRPSYFMQNFINVQHRMSIQTEGRITTASGEGK LGFIDADDIAETAVRALIDDVPHQTHHILTGPEALSYAEAAEIIGAAAGRRVEHVSIS RSELQHKMEAGGLPADYAHFMAKLDEAISHGAEHRVTDTVKRVTGKEPRSLSEFAAAH AAYWTSFWTE*" /label="yesF CDS" gene 679145..680005 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" /label="yesF gene" promotor_-35 680067..680072 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 680088..680106 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 680088 /Source="Nicolas_upshifts" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(680110..680124) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(680115) /Source="Nicolas_upshifts" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(680132..680136) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 680132..680380 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388570.1" /db_xref="EnsemblGenomes-Gn:BSU06890" /db_xref="EnsemblGenomes-Tr:CAB12508" /db_xref="InterPro:IPR020256" /db_xref="SubtiList:BG11799" /db_xref="UniProtKB/Swiss-Prot:Q45536" /translation="MKDMQPFTPVKSYTPFHSRFDPCPPIGKKYYRTPPNLYMTFQPE HMEQFSPMEALRKGTLWKDLYDFYENPYRGGDAHGKKG*" /label="cotJA CDS" gene 680132..680380 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" /label="cotJA gene" CDS 680364..680627 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388571.2" /db_xref="EnsemblGenomes-Gn:BSU06900" /db_xref="EnsemblGenomes-Tr:CAB12509" /db_xref="InterPro:IPR016571" /db_xref="InterPro:IPR024207" /db_xref="SubtiList:BG11800" /db_xref="UniProtKB/Swiss-Prot:Q45537" /translation="MAKKVDAEYYRQLEQIQAADFVLVELSLYLNTHPHDEDALKQFN QYSGYSRHLKRQFESSYGPLLQFGNSPAGKDWDWGKGPWPWQV*" /label="cotJB CDS" gene 680364..680627 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" /label="cotJB gene" CDS 680642..681211 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" /EC_number="1.11.1.6" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7768848, 9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7768848, 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="enzyme component of the inner spore coat" /protein_id="NP_388572.1" /db_xref="EnsemblGenomes-Gn:BSU06910" /db_xref="EnsemblGenomes-Tr:CAB12510" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG11801" /db_xref="UniProtKB/Swiss-Prot:Q45538" /translation="MWVYEKKLQYPVKVSTCNPTLAKYLIEQYGGADGELAAALRYLN QRYTIPDKVIGLLTDIGTEEFAHLEMIATMVYKLTKDATPEQLREAGLGDHYVNHDSA LFYHNAAGVPFTASYIQAKGDPIADLYEDIAAEEKARATYQWLIDISDDPDLNDSLRF LREREIVHSMRFREAVEILKEERDKKKIF*" /label="cotJC CDS" gene 680642..681211 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" /label="cotJC gene" S_feature 681212..681290 /Source="Nicolas_S_feature" /locus_tag="new_756987_757065" /HighExp="S4, S5, S3, S7, S6, B36, LoTm, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S246" promotor_-35 681263..681268 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 681283..681302 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 681292 /Source="Nicolas_upshifts" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="upshifts" CDS 681336..681878 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388573.1" /db_xref="EnsemblGenomes-Gn:BSU06920" /db_xref="EnsemblGenomes-Tr:CAB12511" /db_xref="GOA:O31513" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11809" /db_xref="UniProtKB/Swiss-Prot:O31513" /translation="MTAFKIENETIADGFYACPAVYEDAESITGLLVRTAEWLRDRGS NQWSGLLKGQDIHDITGSIEKGHVFVFKKDEELAAVVMLLPAPSEWDRTLWGDDGHEE SIYLHRLAVSRRFAGQGLGARVLQWAETGIHFPEKTRIRLDCVADSDALHSFYRRMGY EFMGADASGYHLFEKEITAE*" /label="yesJ CDS" gene 681336..681878 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" /label="yesJ gene" downshifts 681845 /Source="Nicolas_upshifts" /id="D342" /incds=0 /nref=104 /ntot=251 /MaxReadThrough="3.04389" /MaxDrop="4.5316" /score="8.56782582" /energy="-5.8" /TU="U528" /idTUdmin="U530" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS 681901..682203 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_388574.2" /db_xref="EnsemblGenomes-Gn:BSU06930" /db_xref="EnsemblGenomes-Tr:CAB12512" /db_xref="GOA:O31514" /db_xref="InterPro:IPR025434" /db_xref="SubtiList:BG12845" /db_xref="UniProtKB/Swiss-Prot:O31514" /translation="MSFSKREAGDVWSILFVTGIVTACLFAGVSVLMRMRFPDKSRPE WMLAGLIVLGVFAIWYSLVYVRGWEGAALGMLGFNVIFGAIAGYLIDKAIRRYRKR*" /label="yesK CDS" gene 681901..682203 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" /label="yesK gene" promotor_-35 682246..682254 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 682265..682283 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 682271 /Source="Nicolas_upshifts" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="upshifts" CDS 682318..682947 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25441682; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease or sensor of a three componentsystem for pectin and rhamnogalacturonan transport anddegradation" /protein_id="NP_388575.1" /db_xref="EnsemblGenomes-Gn:BSU06940" /db_xref="EnsemblGenomes-Tr:CAB12513" /db_xref="GOA:O31515" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12846" /db_xref="UniProtKB/Swiss-Prot:O31515" /translation="MLMIHSVANGLNHFCTWVMRLAYLNVLWILFSLAGLVVFGLMPA TAAMFTVAREWAKGNTDAPVFSVFFRTFKKEWRASQILGLIVVTAALFLFADMRIAAQ MDQPVLVNVFVSISLIFAFVVLYVFPVFSHFDVKIREVLSISFFIAFSRPAVTLLMAA GAVGVLCLVLFHVTFLLFFSGSLLSLILTKLSFKAFRSMDQRQEKEKAA*" /label="yesL CDS" gene 682318..682947 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" /label="yesL gene" CDS 682944..684677 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 23436677, 25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 23436677, 25441682; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YesN]" /protein_id="NP_388576.1" /db_xref="EnsemblGenomes-Gn:BSU06950" /db_xref="EnsemblGenomes-Tr:CAB12514" /db_xref="GOA:O31516" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12847" /db_xref="UniProtKB/Swiss-Prot:O31516" /translation="MKKRVAGWYRRMKIKDKLFVFLSLIMAVSFLFVYSGVQYAFHVY DEQIYRKSSEVLRMSSERIEDELKKIEDVSYEIITDEQIQRILSMQNRDDTYDQYQMK QELWDQLAGYASDEKYIDSIHVIDARGSEYSAGSSSSDLLQQEQEEVFKRAKAKSGRN LWMTLGGSDPVLISARQIRSYHQLSLNGLGMVLIQVNVKQMIRDVPKDWGDSVGDIMI ADQGGNLVYTAHASAHVPEAAKETLKHPGYDLIKKNGKRYFISYLQSSYQNWSYYNVI PFDQMFAKISFMKTVIGTCFLLFFCVVLLFGRKIANSITEPIEQLVTAMKSVQHSGIE AGVSLSLPEHTQDEAGMLNRHFTVMMKRINELMEENVEKQLIIKETELKALQAQINPH FLYNTLESINWLAKANQQKQISKMVESLGFLLRNSIHMKKDIVTIQEEADIVRHYMTI QRFRFEERLKFTLDIDDEVKHCLIPKLTLQPLAENAIQYALEPFTRPCAIRIQAKKAK GCVCITVEDNGPGMDGRILESTGGRGIGLWNIRERISLTFGEPYGLRIHSEHEKGTRI VITIPCRNEVV*" /label="yesM CDS" gene 682944..684677 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" /label="yesM gene" CDS 684677..685783 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25441682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YesM]" /protein_id="NP_388577.1" /db_xref="EnsemblGenomes-Gn:BSU06960" /db_xref="EnsemblGenomes-Tr:CAB12515" /db_xref="GOA:O31517" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12848" /db_xref="UniProtKB/Swiss-Prot:O31517" /translation="MYKILLADDERIILDGMAGIIEWESLGASLIGKAQNGHEAYEKI VHKQPHIVITDVKMPGMDGLELIKKVSAVSPSVQFIVLSGFGEFEYAKEAMKYGVKHY LLKPCNEQQIISSLEEIIAELKRQDVHKKKTAHLKHELDHIRSFAADQYLEGLIAGVA QLSPPPSLAGKKIRLLILKGEQSIDAAAREALGSALTAVCSSGEWTVLAVEENAAEKV AEVFADRKMAISQAGELRHAGQLFRDTAEASGDLHGSAVISKMIRLIADELGNPNLSL KWAAKDMLFMNPDYLGKLFKQETGEKFSQYVTRVRLEHAMKQMKIRRDVSVSEIAEEI GFGDNPKYFSLVFKKYTGLTPSEFRRKQGGASAG*" /label="yesN CDS" gene 684677..685783 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" /label="yesN gene" downshifts 685737 /Source="Nicolas_upshifts" /id="D343" /incds=0 /nref=4 /ntot=43 /MaxReadThrough="0.271749999999999" /MaxDrop="3.41261" /score="3.12085441" /energy="-10.3" /TU="NA" /idTUdmin="U531" /TUdmin=1408 /isTUend="FALSE" /label="downshifts" promotor_-35 685822..685825 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 685840..685859 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 685847 /Source="Nicolas_upshifts" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 685887..687170 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 25658435" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 25658435; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="pectin degradation byproducts (rhamnose oligosaccharides)-binding lipoprotein" /protein_id="NP_388578.2" /db_xref="EnsemblGenomes-Gn:BSU06970" /db_xref="EnsemblGenomes-Tr:CAB12516" /db_xref="PDB:4R6K" /db_xref="SubtiList:BG12849" /db_xref="UniProtKB/Swiss-Prot:O31518" /translation="MKKICYVLLSLVCVFLFSGCSAGEEASGKKEDVTLRIAWWGGQP RHDYTTKVIELYEKKNPHVHIEAEFANWDDYWKKLAPMSAAGQLPDVIQMDTAYLAQY GKKNQLEDLTPYTKDGTIDVSSIDENMLSGGKIDNKLYGFTLGVNVLSVIANEDLLKK AGVSINQENWTWEDYEKLAYDLQEKAGVYGSNGMHPPDIFFPYYLRTKGERFYKEDGT GLAYQDDQLFVDYFERQLRLVKAKTSPTPDESAQIKGMEDDFIVKGKSAITWNYSNQY LGFARLTDSPLSLYLPPEQMQEKALTLKPSMLFSIPKSSEHKKEAAKFINFFVNNEEA NQLIKGERGVPVSDKVADAIKPKLNEEETNIVEYVETASKNISKADPPEPVGSAEVIK LLKDTSDQILYQKVSPEKAAKTFRKKANEILERNN*" /label="yesO CDS" gene 685887..687170 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" /label="yesO gene" CDS 687167..688096 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388579.1" /db_xref="EnsemblGenomes-Gn:BSU06980" /db_xref="EnsemblGenomes-Tr:CAB12517" /db_xref="GOA:O31519" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12850" /db_xref="UniProtKB/Swiss-Prot:O31519" /translation="MTGNGADAMKKSRSIRKDNLAGYAFISPFIIGFLCFTVIPMGAS LFLSFTSYDLFTAPKWIGLDNFKEMFTGDEKYWQSLKVTFTYVLAGVPLRLGFALFIA VILNNAAKGTAIYRTLFYLPSIIGGSVAVAIMWRNIFGNDGVINALLFFVGIDQKILW YQNPTSALWTLILLSVWQFGSSMLIFLAGLKNIPSSYLEAASVDGANRVQRFFKITLP ILTPIIFFNLVMQTISAFMTFTPAYIISKGEGGPLDGTLLYSLYLFQRAFNYFQMGYA SAMAWVMLVIVGLITLILFKTSSYWVHYESKEE*" /label="rhgP CDS" gene 687167..688096 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" /label="rhgP gene" CDS 688100..688990 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388580.1" /db_xref="EnsemblGenomes-Gn:BSU06990" /db_xref="EnsemblGenomes-Tr:CAB12518" /db_xref="GOA:O31520" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12851" /db_xref="UniProtKB/Swiss-Prot:O31520" /translation="MEPVNQPVREAPVFERKKAGRVSPKRILFHVFTATLAVLLLYPV IWLFVSSFKESASIFTTSHSLIPDPFILSNYAEGWKGIAGQPFLTFIKNSAIIVGLST IGAVMSSAVIAYGFARIPFKGKKFWFACMMGTLMLPHEVLMIPQYIMFAKLDWLNSFK PIVVPQFFGHAFFIFLMIQFIRTIPEELDEAARIDGCGRFACFWRIILPLIAPALATS AIFSFYWKWEELIQPLLYLNKPELYPVSLALKLFLDTESASNWGAMFAMSAVSLLPVI LVFFLFQKYIVQGISTTGLK*" /label="rhgQ CDS" gene 688100..688990 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" /label="rhgQ gene" CDS 689006..690040 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" /EC_number="3.2.1.172" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan hydrolase" /protein_id="NP_388581.1" /db_xref="EnsemblGenomes-Gn:BSU07000" /db_xref="EnsemblGenomes-Tr:CAB12519" /db_xref="GOA:O31521" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="SubtiList:BG12852" /db_xref="UniProtKB/Swiss-Prot:O31521" /translation="MAQLIFDEEKVTSVIDRIVKRTFQMDFAWDWPGGVAFYGVAEAY EATENEEYINLLKTWVDEQLEDGLPPLSINGVSIGHTLLFLHKVTGDDVYLETAAEMA EYVLHKAPRFGEGILQHTVNAAEYVFPEQAWADTLMMAGLFMLRIGRVMEREDYFEDG LRQFHGHEDVLQDPVTNLYYHAWDNKAQNHLSGIYWGRANGWAALTMAKALPLIEVTH PSFMIIDGSLRDQLSALVRLQDESGLWHTILDDPDSYLEVSASAGIASALMSSGKLYT KYVQKSLAAILDAVEEDGRVSRVSAGTAVMKNAEGYKQVPYKRIQGWGQGLALTFLAD VLKTKKRLYQ*" /label="rhgH CDS" gene 689006..690040 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" /label="rhgH gene" CDS 690063..692348 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19651770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19651770; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AraC/XylS family)" /protein_id="NP_388582.1" /db_xref="EnsemblGenomes-Gn:BSU07010" /db_xref="EnsemblGenomes-Tr:CAB12520" /db_xref="GOA:O31522" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG12853" /db_xref="UniProtKB/Swiss-Prot:O31522" /translation="MKKQPQQKERVSRWKGTYFKRNFVFILLIACIPGLLTGGAIYFL SIDKVEKELQRSHETQVAREVSRMDEKLGVLELALTQMAYDSSLMNGLAERDLEKDFT FSYQLTKKLFLLRDQQPLIEQASIFLNSPRPLVLSPEYSALTEQEALRKYRSLLASDH SIYWKRSGNQAMLIQLIPGAAEKPFGAIMLAVDPKEMESILQSLSPYPDGSALLLDQN REVLFHEGEKDFEKTLLHEIKKQPAENGHFQMEWKGKVYSVSFGEMNRMHQQWTFVSA APLSAITAPMVFLSKVIIVMLVICIGLAVCMTWYASKKIYRPIQHLLGLFTGGEKKTW QASGQDEFKWIEKRWQDLSLESRKLQQQLLRQTPHMKKSFLQHLLQSDFYYDNEESLR FRMEEAGWNIGGNVFHVLDLQVTGLRCEKSIFREGDEQLAVFTLTNIAEELAAKRVFQ LSILDIGRLSVTVLVMKTNSSDLKAYITELARQFGDVTGLCLTSTLSSKTERVTEIPS LFQDVKCGKSRRKFANRDQVIDLQADFPRDEQFAPYYPFELEKQIVQTIRLERKQEAK ELIDGCMKELSEKAAIDRHVHSALIQLFSRIQEDILHSGLNPSELFQHRNPFLDISEL REPNEAAAWLMDVVVTPYLSKLEGRKNRQQKQLAERVIAMIHEQYMADISLESCADAL GMNSYTLSKAFKQVTGINFIDYVTQIRIEKAKELLVNTNKKIHDVSEEVGYRHNYFNR IFKKQVGMPPGVFRQMYQETP*" /label="rhgR CDS" gene 690063..692348 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" /label="rhgR gene" CDS 692362..693060 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 17957779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 17957779; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388583.1" /db_xref="EnsemblGenomes-Gn:BSU07020" /db_xref="EnsemblGenomes-Tr:CAB12521" /db_xref="GOA:O31523" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12854" /db_xref="UniProtKB/Swiss-Prot:O31523" /translation="MMKKPIQVFLAGDSTVSDCPPHEAPMAGWGQVFGQLFSEGVLVR NHAKGGASTNSFVEEGRLQAIAEHITQGDYLLIQFGHNDQKPRGTKPYSTFQQFLTLF ADTAREKGAHPVFVTSVQRRRFDENGRIEHTLGEYPDAMKALAKELDVPVIDLLAKTK VLYEAYGPEESKRLFVWFQPNEHPNYPDGIEDNTHFSEKGAMEVAKLVAEGIEELGLP LKDHLVSREGKEHV*" /label="rhgT CDS" gene 692362..693060 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" /label="rhgT gene" CDS 693053..693715 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388584.1" /db_xref="EnsemblGenomes-Gn:BSU07030" /db_xref="EnsemblGenomes-Tr:CAB12522" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR015305" /db_xref="PDB:1OQ1" /db_xref="SubtiList:BG12855" /db_xref="UniProtKB/Swiss-Prot:O31524" /translation="MYKEGACLYRNPLRSKSDVKDWRMEGGGQISFDDHSLHLSHVQD EAHFVFWCPETFPDGIIVTWDFSPIEQPGLCMLFFAAAGIRGEDLFDPSLRKRTGTYP EYHSGDINALHLSYFRRKYAEERAFRTCNLRKSRGFHLAAMGADPLPSPDDADSPYRM KLIKDKGYVHFSINGLPILEWMDDGSTYGPVLTKGKIGFRQMAPMKAVYRDFAVHQAV RR*" /label="yesU CDS" gene 693053..693715 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" /label="yesU gene" CDS 693712..694338 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane component" /protein_id="NP_388585.1" /db_xref="EnsemblGenomes-Gn:BSU07040" /db_xref="EnsemblGenomes-Tr:CAB12523" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12856" /db_xref="UniProtKB/Swiss-Prot:O31525" /translation="MKTTVTDALYAGCEAVVKIAWLNGLWLLFTLLGGVLFGWAPSTA AMCAVIRKWLMGQKDVPIFSLFLDTYKKEFLKVNAIGLAFSALLLILSANYHYFSAST NWLSFAVTSCTLLAGLLYIIALMYVFPLYVHYQLPLRKYIPQALLFGAMRPLTTGCML IGCGFVLYLLYTLPGLIPFYGPCLFGLVLMFFALRGFQKTEAQHHQAG*" /label="yesV CDS" gene 693712..694338 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" /label="yesV gene" CDS 694459..696321 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" /EC_number="4.2.2.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan endolyase" /protein_id="NP_388586.1" /db_xref="EnsemblGenomes-Gn:BSU07050" /db_xref="EnsemblGenomes-Tr:CAB12524" /db_xref="GOA:O31526" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2Z8R" /db_xref="PDB:2Z8S" /db_xref="PDB:2ZUX" /db_xref="SubtiList:BG12857" /db_xref="UniProtKB/Swiss-Prot:O31526" /translation="MRRSCLMIRRRKRMFTAVTLLVLLVMGTSVCPVKAEGAARQMEA LNRGLVAVKTDGGIFVSWRFLGTENASVLFNVYRDGQKLNAAPVKTTNYVDKNGSAGS TYTVRAVVNGTEQPASEKASVWAQPYHSVPLDKPAGGTTPKGESYTYSANDASVGDVD GDGQYELILKWDPSNSKDNSQDGYTGDVLIDAYKLDGTKLWRINLGKNIRAGAHYTQF MVYDLDGDGKAEVAMKTADGTKDGTGKVIGNANADYRNEQGRVLSGPEYLTVFQGSTG KELVTANFEPARGNVSDWGDSYGNRVDRFLAGIAYLDGQRPSLIMTRGYYAKTMLVAY NFRDGKLSKLWTLDSSKSGNEAFAGQGNHNLSIADVDGDGKDEIIFGSMAVDHDGKGM YSTGLGHGDALHTGDLDPGRPGLEVFQVHEDKNAKYGLSFRDAATGKILWGVYAGKDV GRGMAADIDPRYPGQEVWANGSLYSAKGVKIGSGVPSSTNFGIWWDGDLLREQLDSNR IDKWDYQNGVSKNMLTASGAAANNGTKATPTLQADLLGDWREEVVWRTEDSSALRIYT TTIPTEHRLYTLMHDPVYRLGIAWQNIAYNQPPHTSFFLGDGMAEQPKPNMYTP*" /label="rhgW CDS" gene 694459..696321 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" /label="rhgW gene" promotor_no_box 694499..694599 /Source="Nicolas_upshift_promotors" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 694559 /Source="Nicolas_upshifts" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(695097) /Source="Nicolas_upshifts" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(695098..695117) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(695130..695139) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 696367..698205 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" /EC_number="4.2.2.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan exolyase" /protein_id="NP_388587.1" /db_xref="EnsemblGenomes-Gn:BSU07060" /db_xref="EnsemblGenomes-Tr:CAB12525" /db_xref="GOA:O31527" /db_xref="InterPro:IPR013517" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2ZUY" /db_xref="SubtiList:BG12858" /db_xref="UniProtKB/Swiss-Prot:O31527" /translation="MKPKKRQMEYLTRGLIAVQTEQGVFVSWRFLGTDHETTAFHLYR DGKRITRDPIAESTNFLDQNGTADSVYQVAAVNKGREEKLSKKARVWQENVLEVPLAK PEGGVTPDGKPYTYSANDASVGDIDGDGEYEMILKWDPSNSKDNAHDGYTGEVLIDAY KLDGTFLWRINLGRNIRAGAHYTQFMVYDLDGDGKAEIAMKTADGTTDGKGHIIGDEQ ADFRNEQGRILSGPEYLTVFKGETGEALTTVEYEPPRGKLEDWGDGYGNRMDRFLAGT AYLDGERPSLVMARGYYTRTVLVAYDFRNGRLKKRWVFDSNQPGHEAYAGQGNHSLSV ADVDGDGKDEIIYGAMAVDHDGTGLYSTGLGHGDAMHVGDLDPSRKGLEVFQVHEDAT KPYGLSLRDAGTGEILWGVHAGTDVGRGMAAHIDPSYKGSLVWGIDPPGNDGMSYGLF TSKGEKISDKAPSSANFAIWWDGDLVRELLDHDWDGTIGRPKIEKWDAENGCLKTIFQ PAGVLSNNGTKGNPVLQANLFGDWREEVIWRTEDSSALRIYTTTHLTRHCFYTLMHDP VYRLGIAWQNTAYNQPPHTSFYLGTGMKKPPKPALYIAGSKAEAPL*" /label="rhgX CDS" gene 696367..698205 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" /label="rhgX gene" CDS 698363..699016 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388588.1" /db_xref="EnsemblGenomes-Gn:BSU07070" /db_xref="EnsemblGenomes-Tr:CAB12526" /db_xref="GOA:O31528" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12859" /db_xref="UniProtKB/Swiss-Prot:O31528" /translation="MANHIYLAGDSTVQTYGDSTNQGGWGQFLGSHLPEHIQVINRAI GGRSSKTFVEEGRLQAILDVIEPDDWLFVQMGHNDASKNKPERYTEPYTTYKQYLKQY IAGAREKGAHPLLITPVARFHYENGVFLNDFPDYCIAMKQTAAEENVQLIDLMEKSLA FFTEKGEEKVYTYFMISEGINDYTHFTKKGANEMAKLVAKGIKELGLPLTESIIKER* " /label="yesY CDS" gene 698363..699016 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" /label="yesY gene" CDS 699024..701015 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17056685, 17449691, 17485082" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17056685, 17449691, 17485082; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-galacturonidase" /protein_id="NP_388589.1" /db_xref="EnsemblGenomes-Gn:BSU07080" /db_xref="EnsemblGenomes-Tr:CAB12527" /db_xref="GOA:O31529" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12860" /db_xref="UniProtKB/Swiss-Prot:O31529" /translation="MRKLYHGACYYPELWDEETIQQDIDIMREVGVNVVRIGEFAWSV MEPEEGKIDVGFFKEIIARLYDSGIETIMCTPTPTPPIWFSHGRPERMHANEKREIMG HGSRQHACTNNPYFRKKAAIITTAIAKELGRLPGLIGWQLDNEFKCHVAECMCETCLR LWHDWLKNRYGVIERLNEAWGTDVWSETYQTFEQVPQPGPAPFLHHASLRTMYQLFSM EMIASFADEQAKIIRCYSDAPITHNGSVMFSVDNERMFQNLDFASYDTYASQENASAF LLNCDLWRNLKQGRPFWILETSPSYAASLESSAYPHADGYLQAEAVSSYALGSQGFCY WLWRQQRSGSEISHGSVLSAWGEPTIGYQNVLAVERARKEIEPIILSTEPVQAEAAMT YSDRAKAFIKTEPHRGLRHRSLVTHFYERILNTGIHRDLIPEGAPLDGYRLLFTPFVP YLSSEFIKKASAFAEAGGIWITGPLTGGRTCEHTIHTDCGLGELEKTSGIKTLFTFPM NENVNTGKAFGITAPLGLWSAVFDTESGNTLGTVEAGPGAGHAFLTERNYGEGKIVML GSLPSGKEGDAMLEALVRHYAEEAVISSRSDVTPGTIVAPRIGENGLVWIVVNMDGKG GSVTLPESGTDLLTHRLEKAGRLAVGPHEYRVIQFDNHS*" /label="rhgZ CDS" gene 699024..701015 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" /label="rhgZ gene" CDS 701059..703632 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388590.2" /db_xref="EnsemblGenomes-Gn:BSU07090" /db_xref="EnsemblGenomes-Tr:CAB12528" /db_xref="SubtiList:BG12861" /db_xref="UniProtKB/Swiss-Prot:O31530" /translation="MKKIKWLSGQPKVTSGVTWGMPWKKGELKKGDRLALMNENAETR YVQSEPSAYWPDGSIKWTKHAAVFGGQENQSFTVHKREVPQPTESLSILETEHDIQVD TGALVCTIHKTGSDFIQSLQINGKPIAAGGRLVAIRETRKESAAKMVLLHERSVSFIK RAAIEQSGPVKAVVKIEGVHVLHKTYEEWLPFVIRLTFYAGLSEIGLVHTQLIDRSGK LEFVKGLGIEFDLFLEGEPYNRHFRFAGEKGMYKEPAQLFGTRKFNERYPLYEKQING EMLSPDEEHKEWFAHGTQNAVWDDVKIVQDSSDHYSLSKRTGKDYAWVGMLHGSRAKG LCYAGGKNGGVALGLRYFFEKYPSALEITGLAGSRPKMTIWLWPPDGEAMDLRHYTGN THVASAYEGFDEMRSDPTGIANTNEISLACFSHMPSDEVLNALADKWQAPPLIVCEPD VYYESKALGVWSIIDTSHPLKKELEEQLDAAFLFYKKEVEQRRWYGFWHYGDVMHTYD PIRHMWRYDLGGYAWQNNELVPTLWLWQAFFRSGREDIFRMAEAMTRHTSETDSFHLG EYAGLGSRHNVVHWGCGCKEARISMAGLHKFYYYLTGDDRTGDLLTEVKDADYALVKT DPMRAFYEKGKHPTHARTGPDWAAFCSNWLAEWERTENSEYLKKIETGINCLKRLPLR LLSGPTFEYDPATSMLHHMGDGIAGGYHMIIAFGAPQVWMELAELLDDWEWEDMLSEF GEFYTLSDEEKRKKSGGALHDGHFHWPMFAAGMTAYAARKKQDPHLAAKAWNLLLEDK LSHTPLPIKPERIETWTQLEELPWVTTNTVSQWCLNVIAALELIGDSLPAKKETSGKK G*" /label="yetA CDS" gene 701059..703632 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" /label="yetA gene" promotor_-10 complement(702381..702399) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(702394) /Source="Nicolas_upshifts" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(702415..702420) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 703754..705262 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921237; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein transporter binding protein for alpha-galacturonides" /protein_id="NP_388591.1" /db_xref="EnsemblGenomes-Gn:BSU07100" /db_xref="EnsemblGenomes-Tr:CAB12529" /db_xref="GOA:P37966" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG10434" /db_xref="UniProtKB/Swiss-Prot:P37966" /translation="MKIRMRKKWMALPLAAMMIAGCSHSETSNSASGSKDTIKIMAPL LSPESPSDKSPSLKALEKYTGKEIKVTWVPDSSYNDKFNIVMASGEMPHAIVIKDKSA GFIKSVKAGAFWELSPYLKDYKNLSQADEKILKNSSVNGEVYGIYRTRDLIRACMIIR TDWLKNVGLDMPETLDDFYEVLKAFKEKDPDGNGKDDTYGMVVPKWMGLGNGSPWDVL QIWFGAPNRYGVENGKLIPDFTTKEYMDALTFFKKLYDEGLINKDFAVMDSAKWNDPV VKGKAGVIVDTGSRASQIQSAMEEADESNKDIIDIVGSLEGPNGKRTFPTSGYSGMIT IPKSSVKTEKELKEVLSFLDKMNDKEAQILTNNGVKGRNYELKDGVFTSLEKNNKSLL YEHEGLAQFSMSIPKSEYYIEDQKTKLFQHRKDIITEGEKIAVFNPAESLVSDVYTQK GAQLDNIILDARTQFIIGEIDEKGFDDAVELWKKSGGNELMKDLNKLYQSSK*" /label="lplA CDS" gene 703754..705262 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" /label="lplA gene" CDS 705317..706273 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388592.1" /db_xref="EnsemblGenomes-Gn:BSU07110" /db_xref="EnsemblGenomes-Tr:CAB12530" /db_xref="GOA:P39128" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10435" /db_xref="UniProtKB/Swiss-Prot:P39128" /translation="METVPKKRDAPVLTAGKGISWMAALKRDKWLYLLLIPGLLYFLI FKYLPMWGVLIAFKDYSPYLGFWKSEWVGFDYFKDFFMNPDFFRLLRNTLMLASLDLL FAFPAPLILALLLNEVRKAVYKRCIQTFIYVPHFVSWTIVVSITFVFFTVDTGVINKL IMSLTGEQISFLSDADWFRPMIVMQSIWKETGWGTILFLAALATVDQEQYEAAIMDGA GRFRRMWHITLPAIRSTIIVLLILRIGSFLNLGFEQVYLMTNSLNRSVADIFDTYVYM MGITQGAYSYSTAVGLFKSVVGIILIFGANYIAKKFDQEGLF*" /label="lplB CDS" gene 705317..706273 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" /label="lplB gene" downshifts complement(705591) /Source="Nicolas_upshifts" /id="D344" /incds=1 /nref=1 /ntot=8 /MaxReadThrough="1.59638" /MaxDrop="4.19822" /score="13.9744253" /energy="-20.3" /TU="NA" /idTUdmin="U538" /TUdmin=2068 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(705617..705717) /Source="Nicolas_upshift_promotors" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(705657) /Source="Nicolas_upshifts" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 706287..707174 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388593.1" /db_xref="EnsemblGenomes-Gn:BSU07120" /db_xref="EnsemblGenomes-Tr:CAB12531" /db_xref="GOA:P39129" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10857" /db_xref="UniProtKB/Swiss-Prot:P39129" /translation="MAEIHTMHNTKAGRVFDVCNILFLGGVGAITILPFLYIIAGSFA TEAELAQRSFFIFPKTFTLDAYKYVFSTPTFLRSMGVSIFITVVGTAVQLFFTFTMAY PLAKRHVKGRNLLLNLVIFSMLFSGGMIPTYLVVKSLGLLDTYWALILPMAINPFNLI IIKNFFQQLPRELEESAKIDGCSEIGVFWRIALPLSKPVIATFALFYAVGIWNDFFHA LLYINDSAKWPLQMVLRQVTILSDLTATNGDTMQNAVPPEQGIKLAVIVIATLPILAV YPFLQKHFAKGMLIGSVKG*" /label="lplC CDS" gene 706287..707174 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" /label="lplC gene" promotor_-35 706921..706926 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 706942..706960 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 706945 /Source="Nicolas_upshifts" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="upshifts" CDS 707183..708523 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23416295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23416295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-galacturonidase" /protein_id="NP_388594.1" /db_xref="EnsemblGenomes-Gn:BSU07130" /db_xref="EnsemblGenomes-Tr:CAB12532" /db_xref="GOA:P39130" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:3FEF" /db_xref="SubtiList:BG10858" /db_xref="UniProtKB/Swiss-Prot:P39130" /translation="MFHISTLDQIKIAYIGGGSQGWARSLMSDLSIDERMSGTVALYD LDFEAAQKNEVIGNHSGNGRWRYEAVSTLKKALSAADIVIISILPGSLDDMEVDVHLP ERCGIYQSVGDTVGPGGIIRGLRAVPIFAEIARAIRDYAPESWVINYTNPMSVCTRVL YKVFPGIKAIGCCHEVFGTQKLLAEMVTERLGIEVPRREDIRVNVLGINHFTWITKAS YRHIDLLPIFREFSAHYGESGYELEGECWRDSVFCSAHRVAFDLFETYGAIPAAGDRH LAEFLPGPYLKQPEVWKFHLTPISFRKQDRAEKRQETERLIVQQRGVAEKASGEEGVN IIAALLGLGELVTNVNMPNQGQVLNLPIQAIVETNAFITRNRVQPILSGALPKGVEML AARHISNQEAVADAGLTKDTGLAFQAFLNDPLVQIDRSDAEQLFNDMLQCIMQS*" /label="lplD CDS" gene 707183..708523 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" /label="lplD gene" S_feature complement(707617..709308) /Source="Nicolas_S_feature" /locus_tag="new_783392_785083_c" /HighExp="H2O2, dia15, Paraq, Lbexp, LBGexp, Salt, LPhT, GM 25, G150, dia0" /AntisenseName="yetF" /AntisenseCor="-0.25986434675098202" /AntisenseRegPval="-4.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S247" S_feature 708524..708605 /Source="Nicolas_S_feature" /locus_tag="new_784299_784380" /HighExp="S5, S4, S6, S3, S7, S8, BT, LoTm, B36, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S248" CDS 708606..709301 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388595.1" /db_xref="EnsemblGenomes-Gn:BSU07140" /db_xref="EnsemblGenomes-Tr:CAB12533" /db_xref="GOA:O31533" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="PDB:3C6F" /db_xref="SubtiList:BG12862" /db_xref="UniProtKB/Swiss-Prot:O31533" /translation="MGNYLSVAVELVCGLGILFIILKLLGKTQFSQITPFDFISALIL GELVGNAVYDHEIKIKEIIFASLLWGVLIYIIEFITQKMKSSRKFLEGEPNIVIRKGE LQYKVMKKNKIDINQLQSLLRQAGSFSIQEVEYAILETNGMVSVLPKSDFDKPTNKDL QIPSKSVSLPITLIIDGEIVRDNLKEAGVDEQWLKQELKKKNIDKTEDVLFAEWHKNK PLYTVTYEQSRST*" /label="yetF CDS" gene 708606..709301 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" /label="yetF gene" downshifts 709299 /Source="Nicolas_upshifts" /id="D345" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.32891" /MaxDrop="3.45213" /score="-0.176154378" /energy="-7.1" /TU="NA" /idTUdmin="U537" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(709338..709664) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" /EC_number="1.14.14.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20180905, 21764939, 21873409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20180905, 21764939, 21873409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388596.2" /db_xref="EnsemblGenomes-Gn:BSU07150" /db_xref="EnsemblGenomes-Tr:CAB12534" /db_xref="GOA:O31534" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12863" /db_xref="UniProtKB/Swiss-Prot:O31534" /translation="MFVQLRKMTVKEGFADKVIERFSAEGIIEKQEGLIDVTVLEKNV RRGDEEVVVMIRWESEDHWKQWEKSDAHIAGHKANKGKPKPDYLISTEVSMYHVRAVK QGTYNQ*" /label="hmoA CDS" gene complement(709338..709664) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" /label="hmoA gene" downshifts complement(709353) /Source="Nicolas_upshifts" /id="D346" /incds=0 /nref=194 /ntot=248 /MaxReadThrough="4.01189" /MaxDrop="6.29183" /score="9.23596913" /energy="-9.1" /TU="U538" /idTUdmin="U539" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 709651 /Source="Nicolas_upshifts" /id="D347" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.96802" /MaxDrop="3.46057" /score="-7.34187128" /energy="-5" /TU="NA" /idTUdmin="U537" /TUdmin=352 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(709687..709706) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(709705) /Source="Nicolas_upshifts" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(709721..709728) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(709768..710130) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase/dioxygenase" /protein_id="NP_388597.1" /db_xref="EnsemblGenomes-Gn:BSU07160" /db_xref="EnsemblGenomes-Tr:CAB12535" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12864" /db_xref="UniProtKB/Swiss-Prot:O31535" /translation="MIKQIGTVAVYVEDQQKAKQFWTEKVGFDIAADHPMGPEASWLE VAPKGAETRLVIYPKAMMKGSEQMKASIVFECEDIFGTYEKMKTNGVEFLGEPNQMEW GTFVQFKDEDGNVFLLKE*" /label="yetH CDS" gene complement(709768..710130) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" /label="yetH gene" promotor_-10 complement(710153..710172) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-10" upshifts complement(710167) /Source="Nicolas_upshifts" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="upshifts" promotor_-35 complement(710185..710191) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-35" S_feature complement(710201..710761) /Source="Nicolas_S_feature" /locus_tag="new_785976_786536_c" /HighExp="S8, S6, S7, S5, BT, B36, G/S, B60, Pyr, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S249" downshifts complement(710233) /Source="Nicolas_upshifts" /id="D348" /incds=0 /nref=38 /ntot=47 /MaxReadThrough="0.395850000000001" /MaxDrop="8.2984" /score="45.4672528" /energy="-13.7" /TU="NA" /idTUdmin="U540" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(710744..710763) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(710761) /Source="Nicolas_upshifts" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(710777..710786) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 710849..710856 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 710865 /Source="Nicolas_upshifts" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 710869..710888 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 710914..711495 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; N-terminal part of YetI" /db_xref="SubtiList:BG12865" /translation="MNIDQLLYQYIIDNTADITEKWFSLRCQLKGELYSASHLSEETK TLLTEQHTFTNITIASAFLEDQTDFQENMTKWAQNVAKNRVEQDVQVHEVVEAISNSR ISFWDAVATFIKENQEIVTNEDADRWNRIVNQSFDKLIIEFSEQYQKFMLMRLTSQQE LISELGCPVISIADGIGILPLIGSIDTKRHRSF*" /label="yetI CDS" gene 710914..711495 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /pseudo /label="yetI gene" CDS 711489..711785 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; C-terminal part of YetI" /db_xref="GOA:O31537" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="PSEUDO:CAB12537.2" /db_xref="SubtiList:BG12873" /db_xref="UniProtKB/Swiss-Prot:O31537" /translation="MLETVPVRCVERKITSLVVDLSGVPIVDTMVAQQLYNLSKTLFL LGVKAVFSGIRPDVAQTSIQLGLDFSEYETYGTLKQALENMGVRCIVEELEENK*" /label="yetI CDS" gene 711489..711785 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /pseudo /label="yetI gene" downshifts 711777 /Source="Nicolas_upshifts" /id="D349" /incds=0 /nref=114 /ntot=215 /MaxReadThrough="1.06939" /MaxDrop="4.8053" /score="16.356572" /energy="-21.2" /TU="NA" /idTUdmin="U541" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 711856..711863 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 711877..711896 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 711885 /Source="Nicolas_upshifts" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="upshifts" CDS 711940..712107 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388600.1" /db_xref="EnsemblGenomes-Gn:BSU07190" /db_xref="EnsemblGenomes-Tr:CAB12538" /db_xref="InterPro:IPR018743" /db_xref="SubtiList:BG12875" /db_xref="UniProtKB/Swiss-Prot:O31538" /translation="MVSKSTIDPEVIEKIISSLETLDFGTVQITVHDSQITQIEKIEK HRFSLKRKESK*" /label="yezD CDS" gene 711940..712107 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" /label="yezD gene" promotor_-35 712149..712156 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 712172..712191 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 712173 /Source="Nicolas_upshifts" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="upshifts" CDS 712217..712861 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" /function="7.4: Cations and iron carrying compounds" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 16086852, 24904158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 16086852, 24904158; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pH-sensitive calcium-leak permease (di-aspartyl pH sensor)" /protein_id="NP_388601.1" /db_xref="EnsemblGenomes-Gn:BSU07200" /db_xref="EnsemblGenomes-Tr:CAB12539" /db_xref="GOA:O31539" /db_xref="InterPro:IPR006214" /db_xref="PDB:4PGR" /db_xref="PDB:4PGS" /db_xref="PDB:4PGU" /db_xref="PDB:4PGV" /db_xref="PDB:4PGW" /db_xref="PDB:4TKQ" /db_xref="SubtiList:BG12866" /db_xref="UniProtKB/Swiss-Prot:O31539" /translation="MQATVHESKQSIMQRILTVFVFTLLIATVGLFIGQFVPVALMLP LSILEVAMIILAFWMRRRKAVGYAFVYTFAFVSGITLFPIVSHYASIAGAYVVLEAFG STFVIFAVLGTIGAKMKKDLSFLWSFLLVAVLALAVVGIFNIFSPLNSAAMMAYSVIG TIVFSLYILYDLNQIKHRHITEDLIPVMALSLYLDFINLFINLLRFFGILSSDD*" /label="calJ CDS" gene 712217..712861 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" /label="calJ gene" downshifts 712797 /Source="Nicolas_upshifts" /id="D350" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="6.69003" /MaxDrop="2.5446" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U541" /TUdmin=1012 /isTUend="FALSE" /label="downshifts" downshifts 712841 /Source="Nicolas_upshifts" /id="D351" /incds=0 /nref=7 /ntot=127 /MaxReadThrough="5.33515" /MaxDrop="3.71552" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" CDS 712861..713853 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388602.1" /db_xref="EnsemblGenomes-Gn:BSU07210" /db_xref="EnsemblGenomes-Tr:CAB12540" /db_xref="GOA:O31540" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12867" /db_xref="UniProtKB/Swiss-Prot:O31540" /translation="MKKRLSLDRRFLPYIKKAGGVLVKKQMGAYVSLAAAMAIVGSSV VVGKLMVERIPVFLSSGLRFLIASVVLLMLLFCIEKGFPALTKKDVFVLLVQSFTGVF LFSICLLYGVQYTTGTESGILTSTTPMLIGILSFFLLREKIEKKTLIGILLAVCGVMA INLFGAGSQDGTPHALFGNMLIIAAVIGEALFTLMAKLLSPHISALAISTFVSLFGFL FFLPFALFEASSFDYSVPTVLDWSYVLYYALFVTVLAFYLWYSGVTKVPAGVSGIFTS VLPVSAVILSGVILKEPFEFVHFIGIACVIGGIFVTVIKKKQPDAYPAAEEKTL*" /label="yetK CDS" gene 712861..713853 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" /label="yetK gene" downshifts 713787 /Source="Nicolas_upshifts" /id="D352" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="4.14475" /MaxDrop="2.73453" /score="21.8095329" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 713831 /Source="Nicolas_upshifts" /id="D353" /incds=0 /nref=94 /ntot=214 /MaxReadThrough="0.120229999999999" /MaxDrop="4.45909" /score="21.8095329" /energy="-10.7" /TU="NA" /idTUdmin="U542" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(713877..714380) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19329649, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19329649, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (FlvL-flavonoids)" /protein_id="NP_388603.1" /db_xref="EnsemblGenomes-Gn:BSU07220" /db_xref="EnsemblGenomes-Tr:CAB12541" /db_xref="GOA:O31541" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12868" /db_xref="UniProtKB/Swiss-Prot:O31541" /translation="MELKHLPKYKHITEHAETYANIDAGSLELFLSLFDISKKMNHVM EHYFAGRGLSEGKFKILMLLFDAKDHRLSPTELAKRSNVTKATITGLLDGLARDGFVS RRHHTEDKRKISIELTTEGKARLEQFLPGHFSKISAVMENYSDEEKDMFVKMLGDLFE RLSVFKD*" /label="flvL CDS" gene complement(713877..714380) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" /label="flvL gene" promotor_-10 complement(714405..714424) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(714413) /Source="Nicolas_upshifts" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(714438..714445) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 714543..715652 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25209494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-dependent hydroxylase/monooxygenase acting on salicylate derivatives" /protein_id="NP_388604.1" /db_xref="EnsemblGenomes-Gn:BSU07230" /db_xref="EnsemblGenomes-Tr:CAB12542" /db_xref="GOA:O06489" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12869" /db_xref="UniProtKB/Swiss-Prot:O06489" /translation="MKHMLIAGGGIGGLSAAISLRKAGFSVTLCEAASENRKTGAGIL QPQNALAVLKELGVFEDCCKHGFQTEWFKTFDEQGNLLFQVSESFLDDSLPGRNNILR KTLNDILMKHAEAVGVDIKWGKKVVAYEETAESVTALCEDGEKMQADILAGFDGIHSV VRDKMLQKETEKEHLGMGAWRFYIELPDYTFEDATFMYRSGDTQIGVVPLAQHAGYVF VLQPCTSDYWDEEDTRFDRVKEILSGFRGLDFVTKHMSKQHPVIFNKLEQVAVQEPWH KGRVIIGGDAAHAGAPTLAQGAAMAIEDAIVLAEELQNHADHETALQAYYKRRAPRAL KVQNLSSEIVRRRLKGEPGAEELIGECYAVLREGY*" /label="flvM CDS" gene 714543..715652 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" /label="flvM gene" downshifts 715635 /Source="Nicolas_upshifts" /id="D354" /incds=0 /nref=7 /ntot=67 /MaxReadThrough="0.0953400000000002" /MaxDrop="5.1482" /score="13.261567" /energy="-12.6" /TU="NA" /idTUdmin="U542" /TUdmin=1804 /isTUend="FALSE" /label="downshifts" CDS complement(715687..716757) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388605.1" /db_xref="EnsemblGenomes-Gn:BSU07240" /db_xref="EnsemblGenomes-Tr:CAB12543" /db_xref="InterPro:IPR025006" /db_xref="InterPro:IPR025012" /db_xref="SubtiList:BG12870" /db_xref="UniProtKB/Swiss-Prot:O06490" /translation="MDFEIRFLSFYVIQVEGKDEQANKQFKHFQTLDTGEFEESELKD FLDGELKKIVKRKADRHPQSEQVPTKIGHFIVEPGHELDSNPNYNMFNRARLAETKED FNELSEQFVRTYLDTSAVRGGVFLVASAVPRKYFDESFVFIMKCDFEPKVARISDASS LIKKVEMAITTKNMKSIQYPYMPEEGMVEEGELKIHQASHARYFEDFLKFVEYGESMP EIMKNQVMNMVQEHVYETFEDNSEELKQFEHDIEIWEASEKREIQERLDTHQVIEASA QIIEHTPEAQLKMKVGETEIKGLLADFGDSIHLAKVNGRYVALIEAETISFEKGSSPV EFYKPEGLHEVIERIRNKTEQD*" /label="yetN CDS" gene complement(715687..716757) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" /label="yetN gene" downshifts complement(715711) /Source="Nicolas_upshifts" /id="D355" /incds=0 /nref=45 /ntot=180 /MaxReadThrough="0.83729" /MaxDrop="4.28938" /score="0.323038441" /energy="-11.6" /TU="NA" /idTUdmin="U545" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(716788..716807) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(716814) /Source="Nicolas_upshifts" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(716822..716829) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 716837..716843 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 716858..716876 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 716867 /Source="Nicolas_upshifts" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="upshifts" CDS 716907..720092 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" /EC_number="1.6.2.4" /EC_number="1.14.14.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11574077, 2544578, 21048857, 26452461; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional P-450/NADPH-P450 reductase 1" /protein_id="NP_388606.1" /db_xref="EnsemblGenomes-Gn:BSU07250" /db_xref="EnsemblGenomes-Tr:CAB12544" /db_xref="GOA:O08394" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12871" /db_xref="UniProtKB/Swiss-Prot:O08394" /translation="MKETSPIPQPKTFGPLGNLPLIDKDKPTLSLIKLAEEQGPIFQI HTPAGTTIVVSGHELVKEVCDEERFDKSIEGALEKVRAFSGDGLFTSWTHEPNWRKAH NILMPTFSQRAMKDYHEKMVDIAVQLIQKWARLNPNEAVDVPGDMTRLTLDTIGLCGF NYRFNSYYRETPHPFINSMVRALDEAMHQMQRLDVQDKLMVRTKRQFRYDIQTMFSLV DSIIAERRANGDQDEKDLLARMLNVEDPETGEKLDDENIRFQIITFLIAGHETTSGLL SFATYFLLKHPDKLKKAYEEVDRVLTDAAPTYKQVLELTYIRMILNESLRLWPTAPAF SLYPKEDTVIGGKFPITTNDRISVLIPQLHRDRDAWGKDAEEFRPERFEHQDQVPHHA YKPFGNGQRACIGMQFALHEATLVLGMILKYFTLIDHENYELDIKQTLTLKPGDFHIS VQSRHQEAIHADVQAAEKAAPDEQKEKTEAKGASVIGLNNRPLLVLYGSDTGTAEGVA RELADTASLHGVRTKTAPLNDRIGKLPKEGAVVIVTSSYNGKPPSNAGQFVQWLQEIK PGELEGVHYAVFGCGDHNWASTYQYVPRFIDEQLAEKGATRFSARGEGDVSGDFEGQL DEWKKSMWADAIKAFGLELNENADKERSTLSLQFVRGLGESPLARSYEASHASIAENR ELQSADSDRSTRHIEIALPPDVEYQEGDHLGVLPKNSQTNVSRILHRFGLKGTDQVTL SASGRSAGHLPLGRPVSLHDLLSYSVEVQEAATRAQIRELASFTVCPPHRRELEELSA EGVYQEQILKKRISMLDLLEKYEACDMPFERFLELLRPLKPRYYSISSSPRVNPRQAS ITVGVVRGPAWSGRGEYRGVASNDLAERQAGDDVVMFIRTPESRFQLPKDPETPIIMV GPGTGVAPFRGFLQARDVLKREGKTLGEAHLYFGCRNDRDFIYRDELERFEKDGIVTV HTAFSRKEGMPKTYVQHLMADQADTLISILDRGGRLYVCGDGSKMAPDVEAALQKAYQ AVHGTGEQEAQNWLRHLQDTGMYAKDVWAGI*" /label="cypD CDS" gene 716907..720092 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" /label="cypD gene" downshifts 720079 /Source="Nicolas_upshifts" /id="D356" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.31156" /MaxDrop="2.91666" /score="9.17315362" /energy="-9.8" /TU="NA" /idTUdmin="U546" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 720142..720147 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 720163..720181 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 720184 /Source="Nicolas_upshifts" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 720212..720215 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 720232..720251 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 720233..720538 /Source="Nicolas_S_feature" /locus_tag="new_796008_796313" /HighExp="H2O2, Paraq, Oxctl, Cold, Heat, LBGexp, G180, G150, HPh, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.841" /TUlongSig="NA" /TUlongPSig="NA" /label="S250" upshifts 720233 /Source="Nicolas_upshifts" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="upshifts" CDS 720539..722458 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11544192, 15187182, 17434969, 17483484, 21255105, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="exported glycerol phosphate lipoteichoic acid synthetase and anion-binding protein" /protein_id="NP_388607.2" /db_xref="EnsemblGenomes-Gn:BSU07260" /db_xref="EnsemblGenomes-Tr:CAB12545" /db_xref="GOA:Q797B3" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG12980" /db_xref="UniProtKB/Swiss-Prot:Q797B3" /translation="MKKLFSYKLSFFVLAVILFWAKTYLSYKTEFNLGVKGTTQEILL IFNPFSSAVFFLGLALLAKGRKSAIIMLIIDFLMTFVLYANILFYRFFDDFLTFPNIK QSGNVGNMGDGIFSIMAGHDIFYFLDIIILIAVLIWRPELKEYKMKKRFASLVILSGI ALFFINLHYAEKDRPQLLTRTFDRNYIVKYLGLYNYTIYDGVQTAQTETQRAYASSDD LTSVENYTTSHYAKPNAEYFGSAKGKNIIKIHLESFQSFLIDYKLNGEEVTPFLNKLA HGGEDVTYFDNFFHQTGQGKTSDAELTMDNSIFGLPEGSAFVTKGENTYQSLPAILDQ KEGYTSAVLHGDYKSFWNRDQIYKHIGYDKFFDASTYDMSDENVINMGLKDKPFFTES IPKLESLKQPFYAHLITLTNHYPFNLDEKDASLKKATTGDNTVDSYFQTARYLDEALE QFFKELKEAGLYDNSVIMIYGDHNGISENHNRAMKEILGKEITDYQNAQNQRVPLMIR VPGKKGGVNHTYGGEIDVMPTLLHLEGIDSQKYINFGTDLFSKDHDDTVAFRNGDFVT PKYTSVDNIIYDTKTGEKLKANEETKNLKTRVNQQLSLSDSVLYKDLLRFHKLNDFKA VDPSDYHYGKEKEIK*" /label="ltaSA CDS" gene 720539..722458 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /label="ltaSA gene" downshifts 722457 /Source="Nicolas_upshifts" /id="D357" /incds=0 /nref=103 /ntot=261 /MaxReadThrough="1.69168" /MaxDrop="7.8227" /score="37.7648461" /energy="-24" /TU="NA" /idTUdmin="U547" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 722546..722555 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 722565..722693 /Source="Nicolas_S_feature" /locus_tag="new_798340_798468" /HighExp="BT, B36, S8, S7, G/S, Pyr, B60, S6, Glucon, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S251" upshifts 722565 /Source="Nicolas_upshifts" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 722569..722588 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(722619) /Source="Nicolas_upshifts" /id="D358" /incds=0 /nref=2 /ntot=6 /MaxReadThrough="1.80969" /MaxDrop="4.63324" /score="20.6569889" /energy="-23.4" /TU="NA" /idTUdmin="U552" /TUdmin=4928 /isTUend="FALSE" /label="downshifts" CDS 722694..723458 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /EC_number="2.7.7.33" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15634670, 16357223, 26577401" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15634670, 16357223, 26577401; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate cytidylyltransferase (sporulation)" /protein_id="NP_388608.1" /db_xref="EnsemblGenomes-Gn:BSU07270" /db_xref="EnsemblGenomes-Tr:CAB12546" /db_xref="GOA:O06486" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR013446" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12979" /db_xref="UniProtKB/Swiss-Prot:O06486" /translation="MKAVILCGGKGTRMSEVTNDIPKPLAMIGGKPILWHIMKIYQYY GVNEFILLLGYKGEKIKEYFLDYEWKHNSLTLDSSTGEVQMLGQPETWKITFLETGVD TLTAGRILQAKDYIGDETFLLTYGDGLANINLFHLISYHQTKGAAATVTGIDKVSQFG TLTVEDGMAKTFSEKTSSDGIINGGFFVLSPKVFDYLPKDGNTMFEDEPLKNLAKDGE LAVYRHYGFWTAIDTYKNLLEVNKMWNQGQQVWKVW*" /label="spmH CDS" gene 722694..723458 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /label="spmH gene" CDS 723465..724433 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CDP-sugar-dehydratase/epimerase" /protein_id="NP_388609.2" /db_xref="EnsemblGenomes-Gn:BSU07280" /db_xref="EnsemblGenomes-Tr:CAB12547" /db_xref="GOA:O06485" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12978" /db_xref="UniProtKB/Swiss-Prot:O06485" /translation="MSFWKNKNVFVTGCTGLLGSYLVKELIEQGANVTGLVRDHVPQS NLYQGEHIKKMNIVRGSLEDLAVIERALGEYEIDTVFHLAAQAIVGVANRNPISTFEA NILGTWNILEACRKHPLIKRVIVASSDKAYGDQENLPYDENMPLQGKHPYDVSKSCAD LISHTYFHTYGLPVCITRCGNLYGGGDLNFNRIIPQTIQLVLNGEAPEIRSDGTFVRD YFYIEDAVQAYLLLAEKMEENNLAGEAFNFSNEIQLTVLELVEKILKKMNSNLKPKVL NQGSNEIKHQYLSAEKARKLLNWTPAYTIDEGLEKTIEWYTEFFKK*" /label="spmG CDS" gene 723465..724433 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /label="spmG gene" CDS 724457..725368 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_388610.1" /db_xref="EnsemblGenomes-Gn:BSU07290" /db_xref="EnsemblGenomes-Tr:CAB12548" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12977" /db_xref="UniProtKB/Swiss-Prot:O06484" /translation="MTSAYCTVLSKGRLYQAVALFKSLEQVDQDSPIFILCMDEDTHR VLQKLKMKQLNLVPVAALENELLLKLKETRDQSEYCWTMKPIFLQAVLNSNPELERVT YIDGDLFFYADPSPIFENQPDCSVLLSRGDIVIPSFEKEQIDMLQRLLGRYNSGFISF KHDDAGTDCLEWWKERCLEECKNAPGEGKFGDQGYLDYMSELFPNVCDITTPGVNIGH WNYGQHTFSWKDGRIVLEDGSPLIFYHFSGYRIVSINEIKQIHETTRTDLPFVHELYQ ETLPHIIQHMQTLDPEFNGFASKDDNK*" /label="yfnF CDS" gene 724457..725368 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /label="yfnF gene" promotor_-35 725246..725255 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 725268..725287 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 725271 /Source="Nicolas_upshifts" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="upshifts" CDS 725397..726575 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388611.1" /db_xref="EnsemblGenomes-Gn:BSU07300" /db_xref="EnsemblGenomes-Tr:CAB12549" /db_xref="GOA:O06483" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12976" /db_xref="UniProtKB/Swiss-Prot:O06483" /translation="MKASVIIPAYNSKERLYNSLLSLNQQECDEEFEVIVADNGSEDG TLSMLESFQADFPLIFTRIKENRGIAYGRNQALRNARGDILIFHDSDMLAAKDLVAKH IKAHENEENLVVCGLFWKRIYSFYYERFEEEHKEQLAKLTGEMPKKDKQKLLEEADIK NGSFLDKSFDLDTDFIDVLKKILDEYGDDLKGYHMPWRFFITNNSSVKRKHVVDLGLF DEGIVRYGFEDYDLGIRLHQAGLTFRLRRDIVSVHQEHPSNCKSVDDIRANIAYMCDK YNNIRSLDVHLAFNGPFPPDMTNRIMADIQKLLESQKYDMLLNLFLELLHVVKERNID PDWRKKSPRVTAKSFDLQTVRKLLPKAKKKLGVNDFANALYALVNDLLHVDLRSLDVV *" /label="yfnE CDS" gene 725397..726575 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /label="yfnE gene" promotor_-35 726116..726122 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 726137..726156 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 726151 /Source="Nicolas_upshifts" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 726576..727511 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388612.1" /db_xref="EnsemblGenomes-Gn:BSU07310" /db_xref="EnsemblGenomes-Tr:CAB12550" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12975" /db_xref="UniProtKB/Swiss-Prot:O31542" /translation="MSTFHFSTIVSRTHIFKLMPMIHSLHEHCDDFHLYVLCVDQKAY ELLQHVPWEHVTFVQLHEMEDPELLKAKSNRTFHEYCWTLKPAFLFHVMSKWDDAEYF AHMDTDLFFFSDPARIFAENPTASLYLTDHRNSPRFMSYYDRTGRFNTGFVGAGNTKE AYEAVWQWRQDCIEFCTVEMDTERKTYGDQRYVEKWPEQFKGVHVVKSIGANTALWNI ENYKVGQKDGRVYIDETPLIFYHFSGFTLVTEKEFNLCWYYRIEDEATIKMIYMPYIL NLKRWIDEIQSAFPDFADGFIPKHAVPDTHFIQLD*" /label="yfnD CDS" gene 726576..727511 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /label="yfnD gene" downshifts 727383 /Source="Nicolas_upshifts" /id="D359" /incds=1 /nref=1 /ntot=52 /MaxReadThrough="5.41459" /MaxDrop="2.6465" /score="34.8532284" /energy="-15.2" /TU="U549,U550" /idTUdmin="U549" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 727493 /Source="Nicolas_upshifts" /id="D360" /incds=0 /nref=2 /ntot=30 /MaxReadThrough="2.32849" /MaxDrop="5.65066" /score="34.8532284" /energy="-15.2" /TU="NA" /idTUdmin="U549" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(727534) /Source="Nicolas_upshifts" /id="D361" /incds=0 /nref=158 /ntot=249 /MaxReadThrough="1.15199" /MaxDrop="4.97014" /score="32.9697757" /energy="-15.2" /TU="NA" /idTUdmin="U552" /TUdmin=13 /isTUend="TRUE" /label="downshifts" CDS complement(727542..728771) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388613.1" /db_xref="EnsemblGenomes-Gn:BSU07320" /db_xref="EnsemblGenomes-Tr:CAB12551" /db_xref="GOA:O06481" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12974" /db_xref="UniProtKB/Swiss-Prot:O06481" /translation="MAIAAPLKEKTVQKPGTTVYPILIIIGICHMLNDSLQAVIPAMF PILERSMSLTFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPVGLTASMLGILG LAFAPSFITILCCVFFIGLGSAIFHPEGSRVAYMAAGTKRGLAQSIYQVGGNSGQAMA PLITALILVPLGQFGAVWFTLVAALAVMFLMYIAKWYASRLGSLAQKSGKQKKTAENT AITKSVVSALIIIIFLIFARSWYTSAIGNFYTFYAMDTYHVSIQQAQSYIFVFLLFGA IGTFLGGPLADRFGKRFVILGSLLCSAPLAIVLPFAGPVLAYGVLALIGLVLMSSFSV TVVYAQELVPGKIGTMSGLTVGLAFGMGAIGAVALGALIDAAGLTPTMIAIAFLPVLG ILAFLLPSDQKLREWHS*" /label="yfnC CDS" gene complement(727542..728771) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /label="yfnC gene" promotor_-10 complement(728800..728819) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(728818) /Source="Nicolas_upshifts" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(728835..728842) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(728882..729589) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine nucleotide phosphatase (promiscuous)" /protein_id="NP_388614.1" /db_xref="EnsemblGenomes-Gn:BSU07330" /db_xref="EnsemblGenomes-Tr:CAB12552" /db_xref="GOA:O06480" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR011951" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3ED5" /db_xref="PDB:3I76" /db_xref="SubtiList:BG12973" /db_xref="UniProtKB/Swiss-Prot:O06480" /translation="MKRYRTLLFDVDDTILDFQAAEALALRLLFEDQNIPLTNDMKAQ YKTINQGLWRAFEEGKMTRDEVVNTRFSALLKEYGYEADGALLEQKYRRFLEEGHQLI DGAFDLISNLQQQFDLYIVTNGVSHTQYKRLRDSGLFPFFKDIFVSEDTGFQKPMKEY FNYVFERIPQFSAEHTLIIGDSLTADIKGGQLAGLDTCWMNPDMKPNVPEIIPTYEIR KLEELYHILNIENTVSC*" /label="pynN CDS" gene complement(728882..729589) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /label="pynN gene" downshifts complement(728911) /Source="Nicolas_upshifts" /id="D362" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="2.75071" /MaxDrop="4.28644" /score="1.09492978" /energy="-15.7" /TU="NA" /idTUdmin="U553" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(729612..729631) /Source="Nicolas_upshift_promotors" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(729635) /Source="Nicolas_upshifts" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(729681..731066) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12022921, 15849754, 16850406, 17114254, 18632116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 15849754, 16850406, 17114254, 18632116; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methylthioribose permease" /protein_id="NP_388615.1" /db_xref="EnsemblGenomes-Gn:BSU07340" /db_xref="EnsemblGenomes-Tr:CAB12553" /db_xref="GOA:Q797A7" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12972" /db_xref="UniProtKB/Swiss-Prot:Q797A7" /translation="MSSLFRKKPLETLSAQSKSKSLARTLSAFDLTLLGIGCVIGTGI FVITGTVAATGAGPALIISFILAGLACALAAFCYAEFSSSIPISGSVYSYSYVTLGEL LAFLIGWDLMLEYVIALSAVATGWSSYFQSLLAGFNLHIPAALTGAPGSMAGAVFNLP AAVIILLITAIVSRGVKESTRFNNVIVLMKIAIILLFIIVGIGYVKPDNWSPFMPFGM KGVILSAATVFFAYLGFDAVSNASEEVKNPQKNMPVGIISALAVCTVLYIAVSLVLTG MMPYAKLNVGDPVSFALKFVGQDAVAGIISVGAIIGITTVMLALLYAQVRLTFAMSRD GLLPGLFAKVHPSFKTPFRNTWLTGIVAAGIAGFINLGTLAHLVNMGTLAAFTVISIA VIVLRKKHPEIKASFRVPFVPVVPIISAGICLWFMYSLPGVTWLSFVIWIAVGTLVYF LYSRKHSLLNK*" /label="mtrA CDS" gene complement(729681..731066) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /label="mtrA gene" downshifts complement(729703) /Source="Nicolas_upshifts" /id="D363" /incds=0 /nref=8 /ntot=91 /MaxReadThrough="3.68565" /MaxDrop="4.73728" /score="31.1617384" /energy="-15.4" /TU="U554" /idTUdmin="U554" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(731115..731134) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(731132) /Source="Nicolas_upshifts" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(731149..731156) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 731234..731241 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 731249 /Source="Nicolas_upshifts" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 731255..731273 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 731316..732773 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /EC_number="1.2.1.67" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15033535, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vanillin dehydrogenase" /protein_id="NP_388616.1" /db_xref="EnsemblGenomes-Gn:BSU07350" /db_xref="EnsemblGenomes-Tr:CAB12554" /db_xref="GOA:O06478" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12971" /db_xref="UniProtKB/Swiss-Prot:O06478" /translation="MFQYEELNKQFIGGKWQEGSSPNVLENKNPYTQKTFTTFRKATA DDVDEAYRAAALAKKKWDAVNPFEKRTILEKAVTYIEENEEAIIYLIMEELGGTRLKA AFEIGLVKNIIKEAATFPIRMEGKILPSTIDGKENRLYRVPAGVVGVISPFNFPFFLS MKSVAPALGAGNGVVLKPHEETPICGGTLIAKIFENAGIPAGLLNVVVTDIAEIGDSF VEHPVPRIISFTGSTKVGSYIGQLAMKHFKKPLLELGGNSAFIVLEDADIEYAVNAAV FSRFTHQGQICMSANRVLVHSSIYDKFLELYQAKVESLKVGDPMDPDTIIGPLINSRQ TDGLMKTVEQAIEEGAVPVKLGGFNGTIVEPTILKDVKPFMSIAKEELFGPVVSFMKF DSEDEAVDIANETPFGLSGAVHTSNLERGVAFAKRIETGMIHVNDTTINDEPNVAFGG EKQSGLGRLNGEWSLEEFTTLKWISVQHEKRSFPY*" /label="vdhT CDS" gene 731316..732773 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /label="vdhT gene" promotor_-10 complement(732109..732128) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(732123) /Source="Nicolas_upshifts" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(732141..732150) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 732787..733647 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="chemotaxis sensory transducer (sensed target unknown)" /protein_id="NP_388617.1" /db_xref="EnsemblGenomes-Gn:BSU07360" /db_xref="EnsemblGenomes-Tr:CAB12555" /db_xref="GOA:O06477" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="SubtiList:BG12970" /db_xref="UniProtKB/Swiss-Prot:O06477" /translation="MELTINTEKETADILDAFIKVAPYLNSLVQDDITIGIYDTEKLL VNIPAKTFSLNVKAGDPLQEGDIITDAIRSNQKKTSMVPKELFGFPLIARAIPLHDEN GRVIGGVGLGTSLEESSKLHDVAESLSAVVEQTAAAISDISESINGFSTQMSGISSQA KKVSESAGEIADISVTVKGISDQSNLLGLNAAIEAARAGESGKGFSVVADEIRKLATH SKENVGQIDQITKKIHSLLKGLEESIESINQHTDGQAAAVEQISATMQEISGSAQHLA KMAEKALEEE*" /label="yfmS CDS" gene 732787..733647 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /label="yfmS gene" downshifts 733631 /Source="Nicolas_upshifts" /id="D364" /incds=0 /nref=208 /ntot=237 /MaxReadThrough="2.9987" /MaxDrop="6.02377" /score="31.9989755" /energy="-16.7" /TU="U555" /idTUdmin="U555" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 733715..733722 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 733736..733755 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 733741 /Source="Nicolas_upshifts" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="upshifts" CDS 733782..735671 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /EC_number="3.6.3.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10715006, 16109936, 18848624, 19948254, 24389465, 24389466; Product type r : regulator" /codon_start=1 /transl_table=11 /product="putative energy-dependent translational throttleA" /protein_id="NP_388618.1" /db_xref="EnsemblGenomes-Gn:BSU07370" /db_xref="EnsemblGenomes-Tr:CAB12556" /db_xref="GOA:O06476" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12969" /db_xref="UniProtKB/Swiss-Prot:O06476" /translation="MSILKAENLYKTYGDKTLFDHISFHIEENERIGLIGPNGTGKST LLKVIAGLESIEEGEITKSGSVQVEFLHQDPELPAGQTVLEHIYSGESAVMKTLREYE KALYELGKDPENEQRQKHLLAAQAKMDANNAWDANTLAKTVLSKLGVNDVTKPVNELS GGQKKRVAIAKNLIQPADLLILDEPTNHLDNETIEWLEGYLSQYPGAVMLVTHDRYFL NRVTNRIYELERGSLYTYKGNYEVFLEKRAEREAQAEQKETKRQNLLRRELAWLRRGA KARSTKQKARIDRVETLKEQTGPQSSGSLDFAIGSHRLGKQVIEAENVMIAYDGRMLV DRFNELVIPGERIGIIGPNGIGKTTLLNALAGRHTPDGGDITIGQTVRIGYYTQDHSE MNGELKVIDYIKETAEVVKTADGDMITAEQMLERFLFPRSMQQTYIRKLSGGEKRRLY LLQVLMQEPNVLFLDEPTNDLDTETLSVLEDYIDQFPGVVITVSHDRYFLDRVVDRLI VFEGNGVISRFQGSYSDYMEESKAKKAAPKPAAEEKTAEAEPKKKRKKLSYKDQLEWD GIEDKIAQLEEKHEQLEADIAAAGSDFGKIQELMAEQAKTAEELEAAMDRWTELSLMI EELES*" /label="ettA CDS" gene 733782..735671 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /label="ettA gene" downshifts 735655 /Source="Nicolas_upshifts" /id="D365" /incds=0 /nref=2 /ntot=134 /MaxReadThrough="2.98669" /MaxDrop="2.72484" /score="30.3267801" /energy="-13.8" /TU="U557" /idTUdmin="U557" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" misc_feature 735735..735754 /Source="Nicolas_upshift_promotors" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 735743 /Source="Nicolas_upshifts" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="upshifts" CDS 735794..736240 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26483775" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388619.1" /db_xref="EnsemblGenomes-Gn:BSU07380" /db_xref="EnsemblGenomes-Tr:CAB12557" /db_xref="GOA:O06475" /db_xref="InterPro:IPR019723" /db_xref="SubtiList:BG12968" /db_xref="UniProtKB/Swiss-Prot:O06475" /translation="MTWAIVMLILMSLVKIVLTCLPTGVIEWLLGKFEVHAKLSDENA SLSLDGKRLEGAEKQKVIDQFNEAIFLEKYYIYPGDEERYLHPENGGTPLVIDTKKGK KDVKLFVYRYDDHIDVVKQYKKKVIAYRVLSESLQKESLSVAGSLA*" /label="yfmQ CDS" gene 735794..736240 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /label="yfmQ gene" downshifts complement(735796) /Source="Nicolas_upshifts" /id="D366" /incds=0 /nref=48 /ntot=154 /MaxReadThrough="1.16717" /MaxDrop="4.57866" /score="0.689181271" /energy="-10.2" /TU="NA" /idTUdmin="U559" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(735880..735883) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(735885) /Source="Nicolas_upshifts" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(735901..735902) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 736227 /Source="Nicolas_upshifts" /id="D367" /incds=0 /nref=254 /ntot=267 /MaxReadThrough="3.12706" /MaxDrop="7.87026" /score="13.6774886" /energy="-8" /TU="U558" /idTUdmin="U557" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 736303..736310 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 736324..736343 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 736336 /Source="Nicolas_upshifts" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="upshifts" CDS 736365..736787 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family) of metal(copper) efflux transporter expression" /protein_id="NP_388620.1" /db_xref="EnsemblGenomes-Gn:BSU07390" /db_xref="EnsemblGenomes-Tr:CAB12558" /db_xref="GOA:O06474" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG12967" /db_xref="UniProtKB/Swiss-Prot:O06474" /translation="MEWMKIDQVAKRSGLTKRTIRFYEEIGLIPAPKRTDGGVRLYSE DDMEELEKVISTKEVLGFSLQELQHFMETSRQLELNKEGYLLSLDPKERKEKLEEIQE TLNHQLDLIDEKIRTFQSFKERLQGMKGKAERAIQSIE*" /label="copP CDS" gene 736365..736787 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /label="copP gene" downshifts 736623 /Source="Nicolas_upshifts" /id="D368" /incds=1 /nref=2 /ntot=135 /MaxReadThrough="4.24358" /MaxDrop="2.69696" /score="13.6774886" /energy="-8" /TU="U560" /idTUdmin="U558" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS 736853..738043 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14663075, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="metal (copper) efflux transporter" /protein_id="NP_388621.1" /db_xref="EnsemblGenomes-Gn:BSU07400" /db_xref="EnsemblGenomes-Tr:CAB12559" /db_xref="GOA:O06473" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12966" /db_xref="UniProtKB/Swiss-Prot:O06473" /translation="MDKTTQVNQKTGLLSQPKAVWAVAFACVISFMGIGLVDPILPAI AAQLHASPSEVSLLFTSYLLVTGFMMFFSGAISSRIGAKWTLILGLIFIIVFAGLGGS SSSIAQLVGYRGGWGLGNALFISTALAVIVGVSVGGSAQAIILYEAALGLGISVGPLA GGELGSISWRAPFFGVSVLMFIALIAISFMLPKLPKPAKRVGVFDAMKALKYKGLLTM AVSAFLYNFGFFILLAYSPFVLDLDEHGLGYVFFGWGLLLAITSVFTAPLVHKALGTV RSLVVLFIAFAAILVIMGIWTDHQTLIITCIVVAGAVLGMVNTIMTTAVMGSAPVERS IASSAYSSVRFIGGALAPWIAGMLSEHFTASTPYTVGGIVVFVGMLVLLMGRKHLAGI KAGH*" /label="copO CDS" gene 736853..738043 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /label="copO gene" downshifts complement(738107) /Source="Nicolas_upshifts" /id="D369" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="-0.0437700000000003" /MaxDrop="2.92105" /score="-8.93016606" /energy="-11.6" /TU="NA" /idTUdmin="U562" /TUdmin=528 /isTUend="FALSE" /label="downshifts" CDS 738334..738489 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388622.1" /db_xref="EnsemblGenomes-Gn:BSU07410" /db_xref="EnsemblGenomes-Tr:CAB12560" /db_xref="SubtiList:BG12965" /db_xref="UniProtKB/Swiss-Prot:O06472" /translation="MDKAKPDEYDQKCLETLYQYIHSVMKNSFSRSSGLPLGKMRRIL SCLPKES*" /label="yfmN CDS" gene 738334..738489 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /label="yfmN gene" CDS complement(738609..740165) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /EC_number="3.6.3.-" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 16109936, 16684363, 22333191, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388623.2" /db_xref="EnsemblGenomes-Gn:BSU07420" /db_xref="EnsemblGenomes-Tr:CAB12571" /db_xref="GOA:O34512" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12964" /db_xref="UniProtKB/Swiss-Prot:O34512" /translation="MSILSVKDLSHGFGDRAIFNNVSFRLLKGEHVGLIGANGEGKST FMNIITGKLEPDEGKVEWSKNVRVGYLDQHTVLEKGKSIRDVLKDAFHYLFAMEEEMN EIYNKMGEADPDELEKLLEEVGVIQDALTNNDFYVIDSKVEEIARGLGLSDIGLERDV TDLSGGQRTKVLLAKLLLEKPEILLLDEPTNYLDEQHIEWLKRYLQEYENAFILISHD IPFLNSVINLIYHVENQELTRYVGDYHQFMEVYEVKKQQLEAAYKKQQQEVAELKDFV ARNKARVSTRNMAMSRQKKLDKMDMIELAAEKPKPEFHFKPARTSGKLIFETKDLVIG YDSPLSRPLNLRMERGQKIALYGANGIGKTTLLKSLLGEIQPLEGSVERGEHIYTGYF EQEVKETNNNTCIEEVWSEFPSYTQYEIRAALAKCGLTTKHIESRVSVLSGGEKAKVR LCKLINSETNLLVLDEPTNHLDADAKEELKRALKEYKGSILLISHEPDFYMDIATETW NCESWTTKVL*" /label="ettM CDS" gene complement(738609..740165) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /label="ettM gene" downshifts complement(738633) /Source="Nicolas_upshifts" /id="D370" /incds=0 /nref=173 /ntot=264 /MaxReadThrough="0.35675" /MaxDrop="5.82627" /score="21.7805812" /energy="-12" /TU="NA" /idTUdmin="U562" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 739995..740001 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 740016..740027 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 740033 /Source="Nicolas_upshifts" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(740215..740234) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(740219) /Source="Nicolas_upshifts" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(740250..740254) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 740275..740278 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 740294..740313 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 740297 /Source="Nicolas_upshifts" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="upshifts" CDS 740338..741468 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11976317; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_388624.1" /db_xref="EnsemblGenomes-Gn:BSU07430" /db_xref="EnsemblGenomes-Tr:CAB12572" /db_xref="GOA:O34750" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12963" /db_xref="UniProtKB/Swiss-Prot:O34750" /translation="MTQTWPFLHNAQSFIQENWNASGFQKPTPVQEQAAQLIMDGKDV IAESPTGTGKTLAYALPVLERIKPEQKHPQAVILAPSRELVMQIFQVIQDWKAGSELR AASLIGGANVKKQVEKLKKHPHIIVGTPGRVFELIKAKKLKMHEVKTIVLDETDQLVL PEHRETMKQIIKTTLRDRQLLCFSATLKKETEDVLRELAQEPEVLKVQRSKAEAGKVK HQYLICDQRDKVKLLQKLSRLEGMQALVFVRDIGNLSVYAEKLAYHHVELGVLHSEAK KMERAKIIATFEDGEFPLLLATDIAARGLDIENLPYVIHADIPDEDGYVHRSGRTGRA GKEGNVLSLVTKLEESKLKKMAKKLGVELSEAVYAGGKLKTK*" /label="yfmL CDS" gene 740338..741468 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /label="yfmL gene" downshifts 741451 /Source="Nicolas_upshifts" /id="D371" /incds=0 /nref=43 /ntot=133 /MaxReadThrough="2.93747" /MaxDrop="4.41385" /score="23.4253604" /energy="-5.9" /TU="NA" /idTUdmin="U563" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS 741536..741982 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388625.1" /db_xref="EnsemblGenomes-Gn:BSU07440" /db_xref="EnsemblGenomes-Tr:CAB12573" /db_xref="GOA:O34536" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12962" /db_xref="UniProtKB/Swiss-Prot:O34536" /translation="MASIDRFQVMQEPELKILEHWFENEDTRRRMDGMLLLDEWYARV NKDKHDTVIMAYDGQLPAGMVVIEFGEERTYIGLIVNPLYRLKGYGKQILQKLMTEPD FTSVREWVACIEEDNRISLACFQAAGFTLEDTEPDEDGFLTLILRN*" /label="yfmK CDS" gene 741536..741982 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /label="yfmK gene" CDS complement(742035..743054) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388626.1" /db_xref="EnsemblGenomes-Gn:BSU07450" /db_xref="EnsemblGenomes-Tr:CAB12574" /db_xref="GOA:O34812" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12961" /db_xref="UniProtKB/Swiss-Prot:O34812" /translation="MTASQQQIQLARRPQGIPVHEDFRFETIPVPEPKQGEVLVKTLY VSVDPYMRGRMQDTKSYVEPFALDKALSGGVIAEVVSDGNHLKKGDIVIGNLSWQEFS AVSESALRKIDTSLAPASAYLGILGMTGLTAYFGLLDIGRPKEGETVVVSGAAGAVGS TVGQIAKIKGARVVGIAGSDEKIDYLKQELQFDEAINYKTADDIQKALQNACPDGVDV YFDNVGGPISDAVMNLLNEFARIPVCGAISSYNAESEADDMGPRVQSKLIKTKSLMQG FIVSDYSDRFSEGAKQLAEWLKAGKLHYEETITEGFENIPDAFLGLFKGENKGKQLIK VSDPS*" /label="yfmJ CDS" gene complement(742035..743054) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /label="yfmJ gene" downshifts complement(742045) /Source="Nicolas_upshifts" /id="D372" /incds=0 /nref=183 /ntot=252 /MaxReadThrough="2.26899" /MaxDrop="5.73395" /score="20.8047206" /energy="-12.8" /TU="NA" /idTUdmin="U564" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(743075..743094) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(743079) /Source="Nicolas_upshifts" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(743081..743535) /Source="Nicolas_S_feature" /locus_tag="new_818856_819310_c" /HighExp="S2, S1, Pyr, T4.0H, T0.0H, T-2.40H, T3.30H, T-1.40H, T-0.40H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S252" promotor_-35 complement(743107..743114) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 743173..743180 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 743194..743213 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 743201..744298 /Source="Nicolas_S_feature" /locus_tag="new_818976_820073" /HighExp="Etha, dia5, Diami, C30, dia15, T5.0H, S8, T3.0H, M0t90, LPhT" /AntisenseName="yfmI" /AntisenseCor="0.135213889213362" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S253" upshifts 743201 /Source="Nicolas_upshifts" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="upshifts" CDS complement(743536..744756) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388627.1" /db_xref="EnsemblGenomes-Gn:BSU07460" /db_xref="EnsemblGenomes-Tr:CAB12575" /db_xref="GOA:O34440" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12960" /db_xref="UniProtKB/Swiss-Prot:O34440" /translation="MSKGYYSILFSQTTTNLGFSLYTMVVISFLFKMTNSTTIASMVT LISIIFRIFGSAILPLITIRLKLPLTIIISQLIQMLLLICLFYALLRTYSNQTLILVF IIISCISFFNGWFSPLKSAIIGEIISPDRRVKANGLLSTVDQTFQFVGWSLGGLIIAF LGEGYTIILTIFLLFTSLLSLLFCLPHGHANSVIREKNSPNKSIVSGWRYLFSQKKLR TIIIMDLIESWAGMIWIGSVSLAFVNEVLHKGESWWGFINGAYYLGSMIGGFIIYKLS ERFQNKLINFMLIGAVSYGSLTLIYGFISNSYLALILVLFMGPAYILRDLTQETLIQN ITTEQTRINIMSARSSLVQFIFMFSILAIGAISDFLGVRLVYVSAGILLLVSAIYGFS QLQFKKKVNKHISF*" /label="yfmI CDS" gene complement(743536..744756) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /label="yfmI gene" promotor_-10 complement(744793..744812) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(744800) /Source="Nicolas_upshifts" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(744828..744835) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 744854..744861 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 744873..745048 /Source="Nicolas_S_feature" /locus_tag="new_820648_820823" /HighExp="LoTm, T-1.10H, T-0.40H, S3, M9-stat, T0.0H, T-1.40H, BC, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.98260400000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S254" upshifts 744873 /Source="Nicolas_upshifts" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 744876..744895 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 745005 /Source="Nicolas_upshifts" /id="D373" /incds=0 /nref=34 /ntot=117 /MaxReadThrough="8.67835" /MaxDrop="8.45742" /score="4.02328636" /energy="-13.7" /TU="U567" /idTUdmin="U565" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS 745092..746555 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388629.1" /db_xref="EnsemblGenomes-Gn:BSU07480" /db_xref="EnsemblGenomes-Tr:CAB12577" /db_xref="InterPro:IPR005532" /db_xref="InterPro:IPR016187" /db_xref="SubtiList:BG12958" /db_xref="UniProtKB/Swiss-Prot:O34722" /translation="MTLLMQDHKSIYNKDIEILIEVEELITSVPENKKNDFKSLIDNR IMTLLNKIQHPVAAENVFGMCIAYPNTYIRYRLIDFVEKWVPYFSAVETIINLTQDPD DLVSFKAMDVCANHKIEESVAYLSSIIDDVRESISYPKKPVGLGAQKVLSTLLDIFGV EKHEELVMLKNYFDQNGILPNNFDFEEKIPQSLIEEFEKTEEDGMILIPGGFFEFGLN ENEIPDKTFNWKDAVPRQKVWLPPFFIDKYPVTNKDYDIFTEFIEENGHIFCHPNEPQ NKQHRRNTYWDDRYLDNHPVTGIDFYDAFAYARYKGKELPTEFQWEKAARGEKGNVWP WGDKFDPAKVQYAGSLYNEPITSLKSWRENLLKAHADKELNHLTSDIFEQNGESPYGV CGMIGGTWEWTRSELKTKRAFHPIFENVPFNSVNSFAVLKGGSFFSHPGLMFPSFRAK DIPFCRHNEMGIRCVKNIPVYKIRESINGPITNKAIY*" /label="yfmG CDS" gene 745092..746555 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /label="yfmG gene" S_feature complement(745457..747127) /Source="Nicolas_S_feature" /locus_tag="new_821232_822902_c" /HighExp="H2O2, C30, Salt, Lbstat, dia15, LPhT, dia5, Paraq, HiOs, Diami" /AntisenseName="yfmG" /AntisenseCor="-0.58045119682782798" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S255" S_feature 746556..747049 /Source="Nicolas_S_feature" /locus_tag="new_822331_822824" /HighExp="LoTm, T0.0H, T-1.40H, T-0.40H, T-2.40H, T-1.10H, Pyr, T-3.40H, SMMPr, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S256" promotor_-35 747037..747042 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 747051..750316 /Source="Nicolas_S_feature" /locus_tag="new_822826_826091" /HighExp="LoTm, Pyr, B36, T3.30H, T2.0H, T-0.40H, T2.30H, B60, T4.0H, T3.0H" /AntisenseName="yfmE" /AntisenseCor="-0.61640022790163695" /AntisenseRegPval="-28.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S257" upshifts 747051 /Source="Nicolas_upshifts" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 747058..747076 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(747128..747928) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16672620, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (ATP-binding protein)" /protein_id="NP_388630.1" /db_xref="EnsemblGenomes-Gn:BSU07490" /db_xref="EnsemblGenomes-Tr:CAB12578" /db_xref="GOA:O34510" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12957" /db_xref="UniProtKB/Swiss-Prot:O34510" /translation="MGKLAADQLTLSYDSTVIIDGVDLKIEEGKITALIGANGCGKST ILKSLARLMAPKSGTVLLEGKDIHRQPSKEVAKKLAILPQSPQAPEGLTVEELCYFGR HPHKKLLSKHTQEDHDMVEWALEATGMIELKDRTLDALSGGQRQRAWISMALAQGTDL LLLDEPTTYLDISHQIEVLELLKKLNRDHGRTVVMVLHDLNQAAQYADYLISVLDGKI YNAGTPEDVFTQPFFREVFGLECCIMRSPIDQKPMCLPTGLCPKLRAK*" /label="fecF CDS" gene complement(747128..747928) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /label="fecF gene" CDS complement(747941..748942) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16672620, 16850406, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388631.1" /db_xref="EnsemblGenomes-Gn:BSU07500" /db_xref="EnsemblGenomes-Tr:CAB12579" /db_xref="GOA:O34832" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12956" /db_xref="UniProtKB/Swiss-Prot:O34832" /translation="MKKTTRKQKRPLLAILILAVILIVLSVISIGIGALYISPDAVVT NLLGLDHSFEFIIQQYRLPRIILAILAGAGLAAAGAILQGVIRNPLASPDVVGISKGS GLAAMAVILIFPESPVYVLPFSAFAGAAIIAVLLLMIARKKSIQPSSLALSGIALGAV CHAGMQYMMVKFPGDVNAALIWLTGSLWGRNWEEVKLLAPWLLILFPIVCILIPKLDL MSLGDELAQGLGENANRLRFILIFTAVALAGSCVAVVGSIGFIGLLAPHIARRLTGEK AKYLLPASALIGAIILLIADTLGRGIMPPVEIPAGILTAVIGAPYFLYLLKFEARKQ* " /label="fecE CDS" gene complement(747941..748942) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /label="fecE gene" promotor_-10 complement(748528..748547) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(748540) /Source="Nicolas_upshifts" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(748562..748569) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(748939..749940) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388632.1" /db_xref="EnsemblGenomes-Gn:BSU07510" /db_xref="EnsemblGenomes-Tr:CAB12580" /db_xref="GOA:O34933" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12955" /db_xref="UniProtKB/Swiss-Prot:O34933" /translation="MYHSAKRRSSSRLMMFIIALIIFIFGLGLNLSVGASDISIIDSL KYLFVWDGSKEQLIISTLRLPRTLIGVFVGASLAVAGALMQAMTRNPLASPQIFGVNA GASLFVVASLVILPASPYSSVIFAFAGAAAGGAIVYMIASSGGMTPVKLALSGMAVHL FLSSMTQAIIILNESGEDVLYWMTGAIDGSNWQDVITIAPFSVIGIGLALVFSGSVSV LGLGDETAKGLGQNMNGIRILISLIILILSGASVAVAGPIGFVGLLVPHIVRKLIGEH YQYVLPFSALFGAILLVYADVLARWIAFPYESPVGIVTAIIGTPFFLYLARKGRNLK* " /label="fecD CDS" gene complement(748939..749940) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /label="fecD gene" misc_feature complement(750010..750029) /Source="Nicolas_upshift_promotors" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(750012..750959) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (binding lipoprotein)" /protein_id="NP_388633.1" /db_xref="EnsemblGenomes-Gn:BSU07520" /db_xref="EnsemblGenomes-Tr:CAB12581" /db_xref="GOA:O34348" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12954" /db_xref="UniProtKB/Swiss-Prot:O34348" /translation="MRTYSNKLIAIMSVLLLACLIVSGCSSSQNNNGSGKSESKDSRV IHDEEGKTTVSGTPKRVVVLELSFLDAVHNLGITPVGIADDNKKDMIKKLVGSSIDYT SVGTRSEPNLEVISSLKPDLIIADAERHKNIYKQLKKIAPTIELKSREATYDETIDSF TTIAKALNKEDEGKEKLAEHKKVINDLKAELPKDENRNIVLGVARADSFQLHTSSSYD GEIFKMLGFTHAVKSDNAYQEVSLEQLSKIDPDILFISANEGKTIVDEWKTNPLWKNL KAVKNGQVYDADRDTWTRFRGIKSSETSAKDVLKKVYNK*" /label="fecC CDS" gene complement(750012..750959) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /label="fecC gene" downshifts complement(750031) /Source="Nicolas_upshifts" /id="D374" /incds=0 /nref=41 /ntot=211 /MaxReadThrough="4.92983" /MaxDrop="4.53674" /score="-3.64310934" /energy="-13.9" /TU="U570,U573,U574" /idTUdmin="U570" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" upshifts complement(750031) /Source="Nicolas_upshifts" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 750286..750291 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 750307..750325 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 750318..750943 /Source="Nicolas_S_feature" /locus_tag="new_826093_826718" /HighExp="LoTm, B36, S5, S6, S4, S7, S8, S3, BT, B60" /AntisenseName="yfmC" /AntisenseCor="-0.52042999587715499" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S258" upshifts 750318 /Source="Nicolas_upshifts" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="upshifts" misc_feature 750939..750958 /Source="Nicolas_upshift_promotors" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 750945..751476 /Source="Nicolas_S_feature" /locus_tag="new_826720_827251" /HighExp="LoTm, B36, S5, S4, S7, S6, S8, B60, S3, BT" /AntisenseName="yfmB" /AntisenseCor="-6.4915194654100006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.997, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S259" upshifts 750945 /Source="Nicolas_upshifts" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(751001..751020) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(751008) /Source="Nicolas_upshifts" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(751034..751041) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(751068..751436) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25651892" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388634.1" /db_xref="EnsemblGenomes-Gn:BSU07530" /db_xref="EnsemblGenomes-Tr:CAB12582" /db_xref="InterPro:IPR021579" /db_xref="PDB:2EUC" /db_xref="SubtiList:BG12953" /db_xref="UniProtKB/Swiss-Prot:O34626" /translation="MQYFSPEQQYNAWIVSDLVKQIFHKRAGCSPGIHELAVFAEEHF HIDIDFVFSIIMNIGDIEFALTDEIEKKLSGYLSTLLPYVTADMFETSKANAHAFLSR RHGNAAYHLFVSDDAFMRKQ*" /label="yfmB CDS" gene complement(751068..751436) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /label="yfmB gene" S_feature complement(751437..751549) /Source="Nicolas_S_feature" /locus_tag="new_827212_827324_c" /HighExp="Etha, BC, Sw, M9-stat, T3.30H, T1.30H, T3.0H, T5.0H, T2.30H, T2.0H" /AntisenseName="yfmA" /AntisenseCor="5.8024036419347599E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S260" promotor_-10 complement(751538..751557) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-10" upshifts complement(751549) /Source="Nicolas_upshifts" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="upshifts" promotor_-35 complement(751569..751576) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-35" promotor_-35 751617..751623 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 751637..751655 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 751637 /Source="Nicolas_upshifts" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="upshifts" CDS 751680..752027 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12089032; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heat stress induced protein" /protein_id="NP_388636.1" /db_xref="EnsemblGenomes-Gn:BSU07550" /db_xref="EnsemblGenomes-Tr:CAB12584" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG19020" /db_xref="UniProtKB/Swiss-Prot:P80241" /translation="MKPVVKEYTNDEQLMKDVEELQKMGVAKEDVYVLAHDDDRTERL ADNTNANTIGAKETGFKHAVGNIFNKKGDELRNKIHEIGFSEDEAAQFEKRLDEGKVL LFVTDNEKVKAWA*" /label="yflT CDS" gene 751680..752027 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /label="yflT gene" downshifts complement(751681) /Source="Nicolas_upshifts" /id="D375" /incds=0 /nref=6 /ntot=28 /MaxReadThrough="1.00082" /MaxDrop="4.87687" /score="-3.31058364" /energy="-3.6" /TU="NA" /idTUdmin="U570" /TUdmin="-1848" /isTUend="FALSE" /label="downshifts" downshifts 752023 /Source="Nicolas_upshifts" /id="D376" /incds=0 /nref=56 /ntot=197 /MaxReadThrough="6.41566" /MaxDrop="7.61596" /score="-1.88723414" /energy="-5.6" /TU="U575" /idTUdmin="U567" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 752068..752148 /Source="Nicolas_S_feature" /locus_tag="new_827843_827923" /HighExp="Etha, Salt, B36, LoTm, Heat, B60, M9-stat, S8, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S261" misc_feature 752149..752168 /Source="Nicolas_upshift_promotors" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 752150 /Source="Nicolas_upshifts" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="upshifts" CDS 752218..753480 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8262178, 12823818, 27447541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8262178, 12823818, 27447541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pectate lyase" /protein_id="NP_388637.1" /db_xref="EnsemblGenomes-Gn:BSU07560" /db_xref="EnsemblGenomes-Tr:CAB12585" /db_xref="GOA:P39116" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="PDB:1BN8" /db_xref="PDB:2BSP" /db_xref="PDB:2NZM" /db_xref="PDB:2O04" /db_xref="PDB:2O0V" /db_xref="PDB:2O0W" /db_xref="PDB:2O17" /db_xref="PDB:2O1D" /db_xref="PDB:3KRG" /db_xref="PDB:5AMV" /db_xref="SubtiList:BG10840" /db_xref="UniProtKB/Swiss-Prot:P39116" /translation="MKKVMLATALFLGLTPAGANAADLGHQTLGSNDGWGAYSTGTTG GSKASSSNVYTVSNRNQLVSALGKETNTTPKIIYIKGTIDMNVDDNLKPLGLNDYKDP EYDLDKYLKAYDPSTWGKKEPSGTQEEARARSQKNQKARVMVDIPANTTIVGSGTNAK VVGGNFQIKSDNVIIRNIEFQDAYDYFPQWDPTDGSSGNWNSQYDNITINGGTHIWID HCTFNDGSRPDSTSPKYYGRKYQHHDGQTDASNGANYITMSYNYYHDHDKSSIFGSSD SKTSDDGKLKITLHHNRYKNIVQRAPRVRFGQVHVYNNYYEGSTSSSSYPFSYAWGIG KSSKIYAQNNVIDVPGLSAAKTISVFSGGTALYDSGTLLNGTQINASAANGLSSSVGW TPSLHGSIDASANVKSNVINQAGAGKLN*" /label="pelA CDS" gene 752218..753480 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /label="pelA gene" downshifts 753475 /Source="Nicolas_upshifts" /id="D377" /incds=0 /nref=139 /ntot=203 /MaxReadThrough="3.61256" /MaxDrop="5.92635" /score="1.82127533" /energy="-8.2" /TU="U575,U576" /idTUdmin="U576" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-35 753533..753536 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 753551..753570 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 753559 /Source="Nicolas_upshifts" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="upshifts" CDS 753607..755043 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12949159, 15849754, 16850406, 25651892, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949159, 15849754, 16850406, 25651892, 28436820; Product type t : transporter" /codon_start=1 /transl_table=11 /product="malate (2-oxoglutarate) transporter" /protein_id="NP_388638.1" /db_xref="EnsemblGenomes-Gn:BSU07570" /db_xref="EnsemblGenomes-Tr:CAB12586" /db_xref="GOA:O34726" /db_xref="InterPro:IPR001898" /db_xref="InterPro:IPR030676" /db_xref="SubtiList:BG12951" /db_xref="UniProtKB/Swiss-Prot:O34726" /translation="MASEKDAGKQSAVKLVPLLITVAVGLIIWFIPAPSGLEPKAWHL FAIFVATIIGFISKPLPMGAIAIFALAVTALTGTLSIEDTLSGFGNKTIWLIVIAFFI SRGFIKTGLGARISYVFVQKFGKKTLGLSYSLLFSDLILSPAIPSNTARAGGIIFPII RSLSETFGSSPANGTERKIGAFLLKTGFQGNLITSAMFLTAMAANPLIAKLAHDVAGV DLTWTSWAIAAIVPGLVSLIITPLVIYKLYPPEIKETPDAAKIATEKLKEMGPFKKSE LSMVIVFLLVLVLWIFGGSFNIDATTTALIGLAVLLLSQVLTWDDIKKEQGAWDTLTW FAALVMLANFLNELGMVSWFSNAMKSSVSGFSWIVAFIILIVVYYYSHYFFASATAHI SAMYSAFLAVVVAAGAPPLLAALSLAFISNLFGSTTHYGSGAAPVFFGAGYIPQGKWW SIGFILSIVHIIVWLVIGGLWWKVLGIW*" /label="maeS CDS" gene 753607..755043 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /label="maeS gene" downshifts 755035 /Source="Nicolas_upshifts" /id="D378" /incds=0 /nref=56 /ntot=132 /MaxReadThrough="2.39993" /MaxDrop="5.36125" /score="40.3051497" /energy="-9.7" /TU="NA" /idTUdmin="U577" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" misc_feature 755134..755153 /Source="Nicolas_upshift_promotors" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 755145 /Source="Nicolas_upshifts" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="upshifts" CDS 755170..756798 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388639.1" /db_xref="EnsemblGenomes-Gn:BSU07580" /db_xref="EnsemblGenomes-Tr:CAB12587" /db_xref="GOA:O34427" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12576" /db_xref="UniProtKB/Swiss-Prot:O34427" /translation="MVKKRFHFSLQTKIMGLIAALLVFVIGVLTITLAVQHTQGERRQ AEQLAVQTARTISYMPPVKELIERKDGHAAQTQEVIEQMKEQTGAFAIYVLNEKGDIR SASGKSGLKKLERSREILFGGSHVSETKADGRRVIRGSAPIIKEQKGYSQVIGSVSVD FLQTETEQSIKKHLRNLSVIAVLVLLLGFIGAAVLAKSIRKDTLGLEPHEIAALYRER NAMLFAIREGIIATNREGVVTMMNVSAAEMLKLPEPVIHLPIDDVMPGAGLMSVLEKG EMLPNQEVSVNDQVFIINTKVMNQGGQAYGIVVSFREKTELKKLIDTLTEVRKYSEDL RAQTHEFSNKLYAILGLLELGEYDEAIDLIKEEYAIQNEQHDLLFHNIHSQQVQAILL GKISKASEKKVKLVIDENSSLAPLPAHIGLSHLITIIGNLIDNAFEAVAEQSVKEVLF FITDMGHDIVIEVSDTGPGVPPEKIEAVFERGYSSKGMRRGYGLANVKDSVRELGGWI ELANQKTGGAVFTVFIPKEKQRGNPFDSHRDCGG*" /label="citS CDS" gene 755170..756798 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /label="citS gene" CDS 756770..757450 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388640.1" /db_xref="EnsemblGenomes-Gn:BSU07590" /db_xref="EnsemblGenomes-Tr:CAB12588" /db_xref="GOA:O34534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR028141" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12577" /db_xref="UniProtKB/Swiss-Prot:O34534" /translation="MIHIAIAEDDFRVAQIHERLIKQLDGFKIIGKAANAKETLALLK EHKADLLLLDIYMPDELGTALIPDIRSRFPEVDIMIITAATETRHLQEALRAGIAHYL IKPVTADKFRQVLLQYKEKRKLLMSQPEVSQSMIDHIFGNGVKTALPAEDLPTGINSI TLRKIKEALQTASEGLTAEELGEKMGASRTTARRYAEYLVSKEEARAELEYGIIGRPE RKYYLAAD*" /label="citT CDS" gene 756770..757450 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /label="citT gene" CDS 757453..758412 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11029430; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative tricarboxylate transporter component" /protein_id="NP_388641.2" /db_xref="EnsemblGenomes-Gn:BSU07600" /db_xref="EnsemblGenomes-Tr:CAB12589" /db_xref="GOA:O34439" /db_xref="InterPro:IPR005064" /db_xref="SubtiList:BG12950" /db_xref="UniProtKB/Swiss-Prot:O34439" /translation="MKKSIILLNILLIFMQGDIRQAAAPRLPDGPIEIVVPAEPSGGW DVTAQAIQSVLRQKQIVKDDVHIVYKSGGGGEKGWKYVNKSSKQTISMTSSLILSNDL LGQSKLKMSDFTPLAILSKEWQTVALPKGSALTNGKDVLNEINMHPGKVRIGFAPGFG NDDQLSFVRAADMYGIDPFDIQFSQYDSSEQLIQALIRHEIEAASMTLSEAKPYERNG DITLAAVTSDKRLPGFPNVPTWKEQGIPFVFSHWRGILGPKNMSEEEISYWDQALKKV TSSPEWKRKINEQDWESFYLNSRETKRFLEEQSAFYQSIMTGN*" /label="yflP CDS" gene 757453..758412 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /label="yflP gene" downshifts 758381 /Source="Nicolas_upshifts" /id="D379" /incds=0 /nref=76 /ntot=211 /MaxReadThrough="1.1681" /MaxDrop="6.31244" /score="10.4510496" /energy="-6.5" /TU="NA" /idTUdmin="U578" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 758504..758511 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 758524..758543 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 758535..758607 /Source="Nicolas_S_feature" /locus_tag="new_834310_834382" /HighExp="M9-stat, SMMPr, SMM, T0.0H, LoTm, T1.0H, Pyr, T1.30H, Cold, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S262" upshifts 758535 /Source="Nicolas_upshifts" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="upshifts" CDS 758608..759909 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="transporter of divalent metal ions/citrate complexes" /protein_id="NP_388642.1" /db_xref="EnsemblGenomes-Gn:BSU07610" /db_xref="EnsemblGenomes-Tr:CAB12590" /db_xref="GOA:P55069" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11832" /db_xref="UniProtKB/Swiss-Prot:P55069" /translation="MLAILGFLMMLVFMALIMTKRLSVLTALVLTPIVFALIAGFGFT EVGDMMISGIQQVAPTAVMIMFAILYFGIMIDTGLFDPMVGKILSMVKGDPLKIVVGT AVLTMLVALDGDGSTTYMITTSAMLPLYLLLGIRPIILAGIAGVGMGIMNTIPWGGAT PRAASALGVDPAELTGPMIPVIASGMLCMVAVAYVLGKAERKRLGVIELKQPANANEP AAAVEDEWKRPKLWWFNLLLTLSLIGCLVSGKVSLTVLFVIAFCIALIVNYPNLEHQR QRIAAHSSNVLAIGSMIFAAGVFTGILTGTKMVDEMAISLVSMIPEQMGGLIPAIVAL TSGIFTFLMPNDAYFYGVLPILSETAVAYGVDKVEIARASIIGQPIHMLSPLVPSTHL LVGLVGVSIDDHQKFALKWAVLAVIVMTAIALLIGAISISV*" /label="citM CDS" gene 758608..759909 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /label="citM gene" promotor_-35 759906..759912 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 759926..759937 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 759927 /Source="Nicolas_upshifts" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="upshifts" CDS 759965..760759 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10972810, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388643.1" /db_xref="EnsemblGenomes-Gn:BSU07620" /db_xref="EnsemblGenomes-Tr:CAB12591" /db_xref="GOA:O34409" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12949" /db_xref="UniProtKB/Swiss-Prot:O34409" /translation="MSDPYMPLTSVRSGAGFEAAKGVHGLTVQIANVYFIQLPSEPHS FVLIDAGMPQSAGVIVNEAKQRFGEGFQLKAIILTHGHFDHIGAIEEILEHWDVPVYI HSREMPYVTGKEDYPPARPDSKSGLVAKLSPLFPRHSIDISSHVQALPEDGSVPFLDE WMWIATPGHTPGHISLFRDDGRVLVAGDAVITVEQEKMADVLIQKQELHGPPAYFTPD TETAAESILKLAGLEPEALLTGHGIPMTGKNFRSDLTELANRLSSI*" /label="yflN CDS" gene 759965..760759 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /label="yflN gene" downshifts 760735 /Source="Nicolas_upshifts" /id="D380" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="0.0114999999999998" /MaxDrop="3.05232" /score="38.3109333" /energy="-11.8" /TU="NA" /idTUdmin="U580" /TUdmin=132 /isTUend="FALSE" /label="downshifts" promotor_-35 760814..760817 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 760832..760851 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 760845 /Source="Nicolas_upshifts" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="upshifts" CDS 760878..761969 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /EC_number="1.14.13.39" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11856757, 12220171, 16172391, 25643072, 25826316, 26062720" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11856757, 12220171, 16172391, 25643072, 25826316, 26062720; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nitric-oxide synthase" /protein_id="NP_388644.2" /db_xref="EnsemblGenomes-Gn:BSU07630" /db_xref="EnsemblGenomes-Tr:CAB12592" /db_xref="GOA:O34453" /db_xref="InterPro:IPR004030" /db_xref="InterPro:IPR017142" /db_xref="InterPro:IPR036119" /db_xref="PDB:1M7V" /db_xref="PDB:1M7Z" /db_xref="PDB:2AMO" /db_xref="PDB:2AN0" /db_xref="PDB:2AN2" /db_xref="PDB:2FBZ" /db_xref="PDB:2FC1" /db_xref="PDB:2FC2" /db_xref="PDB:4D3I" /db_xref="PDB:4D3J" /db_xref="PDB:4D3K" /db_xref="PDB:4D3M" /db_xref="PDB:4D3N" /db_xref="PDB:4D3O" /db_xref="PDB:4D3T" /db_xref="PDB:4D3U" /db_xref="PDB:4D3V" /db_xref="PDB:4D7H" /db_xref="PDB:4D7I" /db_xref="PDB:4D7J" /db_xref="PDB:4LWA" /db_xref="PDB:4LWB" /db_xref="PDB:4UG5" /db_xref="PDB:4UG6" /db_xref="PDB:4UG7" /db_xref="PDB:4UG8" /db_xref="PDB:4UG9" /db_xref="PDB:4UGA" /db_xref="PDB:4UGB" /db_xref="PDB:4UGC" /db_xref="PDB:4UGD" /db_xref="PDB:4UGE" /db_xref="PDB:4UGF" /db_xref="PDB:4UGG" /db_xref="PDB:4UGH" /db_xref="PDB:4UGI" /db_xref="PDB:4UGJ" /db_xref="PDB:4UGK" /db_xref="PDB:4UGL" /db_xref="PDB:4UGM" /db_xref="PDB:4UGN" /db_xref="PDB:4UGO" /db_xref="PDB:4UGP" /db_xref="PDB:4UGQ" /db_xref="PDB:4UGR" /db_xref="PDB:4UGS" /db_xref="PDB:4UGT" /db_xref="PDB:4UGU" /db_xref="PDB:4UGV" /db_xref="PDB:4UGW" /db_xref="PDB:4UGX" /db_xref="PDB:4UGY" /db_xref="PDB:4UQR" /db_xref="PDB:4UQS" /db_xref="PDB:5G65" /db_xref="PDB:5G66" /db_xref="PDB:5G67" /db_xref="PDB:5G68" /db_xref="PDB:5G69" /db_xref="PDB:5G6A" /db_xref="PDB:5G6B" /db_xref="PDB:5G6C" /db_xref="PDB:5G6D" /db_xref="PDB:5G6E" /db_xref="PDB:5G6F" /db_xref="PDB:5G6G" /db_xref="PDB:5G6H" /db_xref="PDB:5G6I" /db_xref="PDB:5G6J" /db_xref="PDB:5G6K" /db_xref="PDB:5G6L" /db_xref="PDB:5G6M" /db_xref="PDB:5G6N" /db_xref="PDB:5G6O" /db_xref="PDB:5G6P" /db_xref="PDB:5G6Q" /db_xref="SubtiList:BG12948" /db_xref="UniProtKB/Swiss-Prot:O34453" /translation="MEEKEILWNEAKAFIAACYQELGKEEEVKDRLADIKSEIDLTGS YVHTKEELEHGAKMAWRNSNRCIGRLFWNSLNVIDRRDVRTKEEVRDALFHHIETATN NGKIRPTITIFPPEEKGEKQVEIWNHQLIRYAGYESDGERIGDPASCSLTAACEELGW RGERTDFDLLPLIFRMKGDEQPVWYELPRSLVIEVPITHPDIEAFSDLELKWYGVPII SDMKLEVGGIHYNAAPFNGWYMGTEIGARNLADEKRYDKLKKVASVIGIAADYNTDLW KDQALVELNKAVLHSYKKQGVSIVDHHTAASQFKRFEEQEEEAGRKLTGDWTWLIPPI SPAATHIFHRSYDNSIVKPNYFYQDKPYE*" /label="nosA CDS" gene 760878..761969 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /label="nosA gene" CDS complement(761960..762235) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /EC_number="3.6.1.7" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:20447399" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20447399; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphatase" /protein_id="NP_388645.1" /db_xref="EnsemblGenomes-Gn:BSU07640" /db_xref="EnsemblGenomes-Tr:CAB12593" /db_xref="GOA:O35031" /db_xref="InterPro:IPR001792" /db_xref="InterPro:IPR017968" /db_xref="InterPro:IPR020456" /db_xref="InterPro:IPR036046" /db_xref="PDB:2FHM" /db_xref="PDB:2HLT" /db_xref="PDB:2HLU" /db_xref="PDB:3BR8" /db_xref="SubtiList:BG12947" /db_xref="UniProtKB/Swiss-Prot:O35031" /translation="MLQYRIIVDGRVQGVGFRYFVQMEADKRKLAGWVKNRDDGRVEI LAEGPENALQSFVEAVKNGSPFSKVTDISVTESRSLEGHHRFSIVYS*" /label="acyP CDS" gene complement(761960..762235) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /label="acyP gene" S_feature 761970..762301 /Source="Nicolas_S_feature" /locus_tag="new_837745_838076" /HighExp="C90, BI, Paraq, LBGexp, Oxctl, M0t45, G150, M40t45, G135, H2O2" /AntisenseName="yflL" /AntisenseCor="0.38657275217332299" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S263" promotor_-10 complement(762249..762268) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(762263) /Source="Nicolas_upshifts" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(762283..762290) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 762302..762967 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11886751; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative sulfur carrier" /protein_id="NP_388646.1" /db_xref="EnsemblGenomes-Gn:BSU07650" /db_xref="EnsemblGenomes-Tr:CAB12594" /db_xref="GOA:O34542" /db_xref="InterPro:IPR005163" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="SubtiList:BG12946" /db_xref="UniProtKB/Swiss-Prot:O34542" /translation="MKQERYSVLSLNLGKPQTLEYDGKKIETGIMKRPAKSAVMLYRE NFEGDGQADLVNHGGPDKAVCVYPAEHYPFWEEFLSRPLSNAAFGENLTVAGLTEENV CIGDVFRLDEAVVQVSQPRQPCVKLAKKFGVKEMVLKVQQTGYTGFYFRVLEEGRVSP GANLELLSRGEKGISVQFANRINYHDAKNLTAIERILSEAALSESWRASFMKKKDRLL PVE*" /label="yflK CDS" gene 762302..762967 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /label="yflK gene" CDS complement(763008..763145) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388647.1" /db_xref="EnsemblGenomes-Gn:BSU07660" /db_xref="EnsemblGenomes-Tr:CAB12595" /db_xref="InterPro:IPR022580" /db_xref="SubtiList:BG12945" /db_xref="UniProtKB/Swiss-Prot:O34345" /translation="MHYGSKGWYVAELKKQGITHHEGRKLQSYKTYFLANLLESKKKQ S*" /label="yflJ CDS" gene complement(763008..763145) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /label="yflJ gene" downshifts complement(763022) /Source="Nicolas_upshifts" /id="D381" /incds=0 /nref=136 /ntot=260 /MaxReadThrough="0.0927600000000002" /MaxDrop="8.10929" /score="29.8336543" /energy="-14.8" /TU="NA" /idTUdmin="U583" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(763146..763276) /Source="Nicolas_S_feature" /locus_tag="new_838921_839051_c" /HighExp="S4, S7, S8, S6, S5, S3, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.967, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S264" promotor_-10 complement(763262..763280) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 763272..763277 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(763276) /Source="Nicolas_upshifts" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="upshifts" S_feature 763287..764351 /Source="Nicolas_S_feature" /locus_tag="new_839062_840126" /HighExp="S8, S6, S5, S7, S4, S3, BT, B36, C90, T5.0H" /AntisenseName="mapB" /AntisenseCor="-0.26446079057314398" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S265" upshifts 763288 /Source="Nicolas_upshifts" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 763293..763311 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(763296..763301) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(763302..763457) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388648.1" /db_xref="EnsemblGenomes-Gn:BSU07670" /db_xref="EnsemblGenomes-Tr:CAB12596" /db_xref="GOA:O34905" /db_xref="SubtiList:BG12944" /db_xref="UniProtKB/Swiss-Prot:O34905" /translation="MWFIIFGIIFFIEGIIMTVYGVKKKNGMLTYIGIVFAIMTFGVV MIKLTGH*" /label="yflI CDS" gene complement(763302..763457) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /label="yflI gene" S_feature complement(763458..763563) /Source="Nicolas_S_feature" /locus_tag="new_839233_839338_c" /HighExp="Etha, Salt, Diami, dia15, H2O2, Cold, G135, Paraq, LPhT, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S266" CDS complement(763564..763878) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1070366, 1266368; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388649.1" /db_xref="EnsemblGenomes-Gn:BSU07680" /db_xref="EnsemblGenomes-Tr:CAB12597" /db_xref="InterPro:IPR021637" /db_xref="PDB:3D0W" /db_xref="SubtiList:BG12943" /db_xref="UniProtKB/Swiss-Prot:O34306" /translation="MNRDQEKIQIENEMNAMHGTIKEDILKDFEEFKGYLKKQVNRGK KLGLDDGKLVKSAAILGDYLAKHEEPQNGEEMLLQELWSVADEDEKEHLAQLLVKLVD KQ*" /label="yflH CDS" gene complement(763564..763878) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /label="yflH gene" S_feature complement(763879..763959) /Source="Nicolas_S_feature" /locus_tag="new_839654_839734_c" /HighExp="dia5, dia15, Diami, LBGtran, LPhT, H2O2, Etha, Lbtran, M40t45, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S267" CDS complement(763960..764709) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase B" /protein_id="NP_388650.1" /db_xref="EnsemblGenomes-Gn:BSU07690" /db_xref="EnsemblGenomes-Tr:CAB12598" /db_xref="GOA:O34484" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG12942" /db_xref="UniProtKB/Swiss-Prot:O34484" /translation="MIVTNDQELEGLKKIGRIVALAREEMKRKAEPGMSTKDLDLIGK AVLDEHGAVSAPEKEYDFPGVTCISVNDEVAHGIPSTSKILKAGDLVNIDISAEFGGF YSDTGISFVLGEGEERLHKLCQCAENAFQKGLQQAKAGKRQNQIGRAVYHEARSQGFT VIKTLTGHGIGRSLHEAPNHIMNYYDPFDNALFKNGTVIALEPFISTKAETIVEAGDG WTFKTPDKSMVAQVEHTIVITKDEPIILTKL*" /label="mapB CDS" gene complement(763960..764709) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /label="mapB gene" promotor_-10 complement(764738..764757) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(764751) /Source="Nicolas_upshifts" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(764753..765889) /Source="Nicolas_S_feature" /locus_tag="new_840528_841664_c" /HighExp="S6, S8, S7, S5, BT, C30, Paraq, B36, G180, Pyr" /AntisenseName="nagP" /AntisenseCor="0.180776000778922" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S268" promotor_-35 complement(764769..764777) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 764820..764821 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 764841..764860 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 764844 /Source="Nicolas_upshifts" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="upshifts" CDS 764881..766239 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 8246840; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) N-acetylglucosamine-specific enzyme IICB component" /protein_id="NP_388651.1" /db_xref="EnsemblGenomes-Gn:BSU07700" /db_xref="EnsemblGenomes-Tr:CAB12599" /db_xref="GOA:O34521" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010974" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG12941" /db_xref="UniProtKB/Swiss-Prot:O34521" /translation="MLSFLQKLGKSFMLPIAVLPAVGIILALGREDVFNIPFVYQAGT AVFDHLPLIFAIGIAIGISKDSNGAAGLSGAISYLMLDAATKTIDKTNNMAVFGGIIA GLIAGYTYNRFKDTKLPEYLGFFSGRRLVPILTAIITIILAGIFGVVWPPIQSCINSF GEWMLGLGGIGAGIFGLFNRLLIPLGLHHVLNNIFWFQFGEYNGVTGDLARFFAKDPT AGTYMTGFFPIMMFGLPAACLAMVVTAKPSKRKATAGMMIGFALTAFITGITEPIEFA FMFLSPLLYAVHAVLTGLSLFIVNWLGIRSGFSFSAGAIDYVLSYGIAEKPLLLLLVG ICYAAVYFIVFYVLIKALNLKTPGREDDDVDEVLDENTVQDVNENIMLKGLGGKENLQ TIDHCATRLRLTVKDTALVDEALLKKAGAKGVVKSGGQSVQVIIGPNVEFAAEELRAA VK*" /label="nagP CDS" gene 764881..766239 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /label="nagP gene" promotor_-10 complement(765875..765894) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(765889) /Source="Nicolas_upshifts" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(765908..765917) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 766125 /Source="Nicolas_upshifts" /id="D382" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="3.67421" /MaxDrop="3.12268" /score="44.7832762" /energy="-16.9" /TU="U586" /idTUdmin="U586" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 766235 /Source="Nicolas_upshifts" /id="D383" /incds=0 /nref=2 /ntot=87 /MaxReadThrough="2.54331" /MaxDrop="3.17508" /score="44.7832762" /energy="-16.9" /TU="NA" /idTUdmin="U586" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(766272..768221) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10658653, 21255105" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658653, 21255105; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_388652.1" /db_xref="EnsemblGenomes-Gn:BSU07710" /db_xref="EnsemblGenomes-Tr:CAB12600" /db_xref="GOA:O34952" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="PDB:2W8D" /db_xref="SubtiList:BG12940" /db_xref="UniProtKB/Swiss-Prot:O34952" /translation="MKTFIKERGLAFFLIAVVLLWIKTYVGYVLNFNLGIDNTIQKIL LFVNPLSSSLFFLGFGLLFKKKLQQTAIIVIHFLMSFLLYANIVYYRFFNDFITIPVI MQAKTNGGQLGDSAFSLMRPTDAFYFIDTIILIILAIKVNKPAETSSKKSFRIIFASS ILVFLINLAVAESDRPELLTRSFDRNYLVKYLGTYNFTIYDAVQNIKSNSQRALADSS DVTEVENYMKANYDVPNNVYFGKAEGKNVIYVSLESLQSFIIDYKIDGKEVTPFLNKL AHDNETFYFDNFFHQTGQGKTSDAEFMMENSLYPLAQGSVFVNKAQNTLQSVPAILKS KNYTSATFHGNTQTFWNRNEMYKAEGIDKFFDSAYYDMNEENTKNYGMKDKPFFKESM PLLESLPQPFYTKFITLSNHFPFGMDEGDTDFPAGDFGDSVVDNYFQSAHYLDQSIEQ FFNDLKKDGLYDKSIIVMYGDHYGISENHNKAMAKVLGKDEITDYDNAQLQRVPLFIH AAGVKGEKVHKYAGDVDVAPTILHLLGVDTKDYLMSGSDILSKEHREVIPFRNGDFIS PKYTKISGKYYDTKTGKELDESEVDKSEDSLVKKELEMSDKIINGDLLRFYEPKGFKK VNPSDYDYTKHDEDSSETSKDNEDK*" /label="ltaSB CDS" gene complement(766272..768221) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /label="ltaSB gene" downshifts complement(766289) /Source="Nicolas_upshifts" /id="D384" /incds=0 /nref=219 /ntot=250 /MaxReadThrough="1.71031" /MaxDrop="6.08461" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U589" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 767331..767337 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 767353..767371 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 767357..768321 /Source="Nicolas_S_feature" /locus_tag="new_843132_844096" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, S8, B60, BC, S7" /AntisenseName="yflE" /AntisenseCor="-0.385555454026206" /AntisenseRegPval="-10.199999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S269" upshifts 767357 /Source="Nicolas_upshifts" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(768222..768296) /Source="Nicolas_S_feature" /locus_tag="new_843997_844071_c" /HighExp="Paraq, H2O2, LBGexp, G150, G135, G180, Lbexp, C30, LPhT, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S270" promotor_-10 complement(768273..768292) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(768296) /Source="Nicolas_upshifts" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(768298..768820) /Source="Nicolas_S_feature" /locus_tag="new_844073_844595_c" /HighExp="S3, LoTm, S7, S4, S5, S8, S6, M9-stat, C30, Pyr" /AntisenseName="yflD" /AntisenseCor="0.24383322556613099" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S271" promotor_-35 complement(768308..768312) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 768322..768459 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388653.1" /db_xref="EnsemblGenomes-Gn:BSU07720" /db_xref="EnsemblGenomes-Tr:CAB12601" /db_xref="SubtiList:BG12939" /db_xref="UniProtKB/Swiss-Prot:O34489" /translation="MREKVAKNAVESTFRFDITKCKTRYLSRNKGIKWYIENCMIKYK V*" /label="yflD CDS" gene 768322..768459 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /label="yflD gene" upshifts 768437 /Source="Nicolas_upshifts" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="upshifts" misc_feature 768438..768457 /Source="Nicolas_upshift_promotors" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 768478..768870 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388655.2" /db_xref="EnsemblGenomes-Gn:BSU07735" /db_xref="EnsemblGenomes-Tr:CAB12603" /db_xref="InterPro:IPR018961" /db_xref="SubtiList:BG12937" /db_xref="UniProtKB/Swiss-Prot:O34887" /translation="MDFSHIVSEDKIKRAIKDGDFQNLPGMGKPLPKDDAAHLPESLR MGYRILKNAGMAEDEGALKKELMTIDHLIEKCYDEKEREQLIRKKSEKQLLLDKLVDK KGMFSKPASAFYKNKVYDRLGRNRPSSS*" /label="yflB CDS" gene 768478..768870 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /label="yflB gene" promotor_-10 complement(768818..768836) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(768833) /Source="Nicolas_upshifts" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(768852..768857) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 768939..768945 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 768960..768978 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 768960 /Source="Nicolas_upshifts" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="upshifts" CDS 768995..770410 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid transporter" /protein_id="NP_388656.1" /db_xref="EnsemblGenomes-Gn:BSU07750" /db_xref="EnsemblGenomes-Tr:CAB12604" /db_xref="GOA:O34708" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12936" /db_xref="UniProtKB/Swiss-Prot:O34708" /translation="MERLLVWIEHISDWLWGPPLIILLTGTGLYFTILLKGFQFRYPL YIFKQTIGSVGKKPKGEGTVTPLQALTSALSSTIGAANIVGVPAAIMFGGPGAVFWMW LIALFAMAIKFSESVLAVHYREKNEQGEYVGGPMYYITKGLRMKWLGVFFSVALIVEL IPSIMVQGNSVSVSLAETFSFNKIYAGIGIAFLIGLVVIGGVKRIGKVTEFVVPLMAG AYAGAGLLIVLMNLSSVPAFFSLVFSNAFTSSSAVGGFAGAALAETVRWGFARGLYSN EAGMGTAPIAHAAAMTDHPVRQGFWSVIGIVIDTLIICTTTAFIVLASGVWTGKNASN DPAALTTAAFQHYFGSGGGYFVSVSLVFFVVSTIMVVIFYGVKQAEFLFGRLAGHVIK FVYLAAIIIGAAGGAKAIWGVLDLALVFIVVPNVIALLLLSRKVKALYTEFFTSEQYY LKDIRKTKQKPVYPTKEAKNS*" /label="yflA CDS" gene 768995..770410 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /label="yflA gene" downshifts complement(768996) /Source="Nicolas_upshifts" /id="D385" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="0.76492" /MaxDrop="4.20973" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U593" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(769022..769122) /Source="Nicolas_upshift_promotors" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(769062) /Source="Nicolas_upshifts" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(770407..771483) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406, 23625846; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane transporter" /protein_id="NP_388657.1" /db_xref="EnsemblGenomes-Gn:BSU07760" /db_xref="EnsemblGenomes-Tr:CAB12605" /db_xref="GOA:O34573" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG12935" /db_xref="UniProtKB/Swiss-Prot:O34573" /translation="MDKTSAYQGLFFGALYTLAVGLKHAPILMIESAKQNAWHSYILG VVIVIPALWLMHRLMKKHQDKNIYELLSDSSPIAGRIIILLFSLYFLLINAHDIRFFI NLINILFLPRTPMAVLGGVIIFVAICIAREGKETLTRMAQIFLFPFGILVLFLPFTLA TQIELQNLTPVFEGLIPYLQSGYYAFGTMGELIILPLLFSNRSVPLKYTIFAILLGAL LLAVMLFSSISVFGPNLTSTFFDPAYMVIRQIRITDFLDRSDLIIAAFWIPVIMVKIA GSLYIVVYGLSFLHSKIDPKAMYTPTGMFSVVCGFWFFLNTNQLIDFNRIKPIINVVI SLLLPLLIYLIIKSKALFGAKAKH*" /label="yfkT CDS" gene complement(770407..771483) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /label="yfkT gene" S_feature 770411..773777 /Source="Nicolas_S_feature" /locus_tag="new_846186_849552" /HighExp="Salt, Sw, Etha, LoTm, B36, Heat, LPhT, BC, T0.30H, H2O2" /AntisenseName="yfkR" /AntisenseCor="-1.3937740774571999E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.952" /label="S272" CDS complement(771507..771707) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative spore germination D protein" /protein_id="NP_388658.1" /db_xref="EnsemblGenomes-Gn:BSU07770" /db_xref="EnsemblGenomes-Tr:CAB12606" /db_xref="GOA:O35036" /db_xref="SubtiList:BG12934" /db_xref="UniProtKB/Swiss-Prot:O35036" /translation="MISYIVQTLIVCIAIYAYEWKNFRSANNLTKWAFSLLIAGSAFL WIYMRVNPLLPRLGHLFKYIPF*" /label="yfkS CDS" gene complement(771507..771707) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /label="yfkS gene" CDS complement(771723..772877) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388659.1" /db_xref="EnsemblGenomes-Gn:BSU07780" /db_xref="EnsemblGenomes-Tr:CAB12607" /db_xref="GOA:O35028" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG12933" /db_xref="UniProtKB/Swiss-Prot:O35028" /translation="MKKTIYKCVLPLLICILLTGCWDRTEINDIAFVVSSAIDKKKDQ YRVAMQIPLVGQLGGQTGGGGGTAGSKTWYVDSASGTTIREANNKLQTSLSRTINTSH RRTVIIGEDMARDGVAPVFDILTRNPQNRLTALILVSRGEARDILNTDVQLEQFPAEM IRELAIIATSRPVFLSRFMSDLVEIGSDPYAPVISASKTKPGGKGKSNLKIDGLAIFK KDRLMDIFKDEHMTAALMLLNQARQPEFIVDLPNQMGQASIQLQKSNASFHAAEKNGK LSMTIEIRAKGIIMENQSTYETRENDQYYIIQKALNRTIKKDVISTVHRLQKLKADPA GFQDRTIRSTATTKNLLKKEWEEVYKDMEVHVVPIVTIEQGGVLYKTISH*" /label="yfkR CDS" gene complement(771723..772877) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /label="yfkR gene" CDS complement(772858..774399) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388660.1" /db_xref="EnsemblGenomes-Gn:BSU07790" /db_xref="EnsemblGenomes-Tr:CAB12608" /db_xref="GOA:O34486" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG12932" /db_xref="UniProtKB/Swiss-Prot:O34486" /translation="MNKRDKALQLIKELEDNQDRPISPNLKENLENLTLLTEGCSDIV FRQFDFGNGLCGFIVYIEGIVKSEHIQDHALRPFLMHLTDQIDEHEEALQNTLSISSV ALETSMSKVAASIIEGNAVLFADGHSKGLILNIKGGQRRSIEEPITESTIRGSREGFT ESLRVNTALVRFRVKTFQLKMISFKIGTKTKTDVVLAYIDGLADPKVIDKAKKRIKKI KIDAVLESGYIEEFIEDDTYSPFPQLQYTERPDTVAAQLLEGRFAIFTDNTPFVLTGP ITFWQLMQASEDYYERYLMSNLIRWLRYMFLFVALYLPAIYVAVITYHQDLMPTNLMF SVASAREPIPFPAIIEALIMEISFEALREAGVRLPKTIGQTVSILGALVIGTAAVEAG IVSAPMVIIVSLTGIASFTIPRFNLAISIRMLRFPLMFLASIFGIFGIMLGTIILVLH LCKLQSFGIPYLSGISPFKRDEVKDIFVRAPWWTMTRRPGTYSRGNGQKGAKREDPKD EENNI*" /label="yfkQ CDS" gene complement(772858..774399) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /label="yfkQ gene" promotor_-10 complement(774449..774460) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(774452) /Source="Nicolas_upshifts" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(774474..774480) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 774509..774516 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 774531..774550 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 774538 /Source="Nicolas_upshifts" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(774584) /Source="Nicolas_upshifts" /id="D386" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="1.35091" /MaxDrop="3.57201" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U596" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 774592..776004 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /EC_number="2.7.1.201" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 8755887, 8917076, 8969503, 18977770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 8755887, 8917076, 8969503, 18977770; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) trehalose-specific enzyme IIBC component" /protein_id="NP_388661.1" /db_xref="EnsemblGenomes-Gn:BSU07800" /db_xref="EnsemblGenomes-Tr:CAB12609" /db_xref="GOA:P39794" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011296" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11009" /db_xref="UniProtKB/Swiss-Prot:P39794" /translation="MGELNKSARQIVEAVGGAENIAAATHCVTRLRFALIDESKVDQE MLDQIDVVKGSFSTNGQFQVVIGQGTVNKVYAELVKETGIGESTKDEVKKASEKNMNP LQRAVKTLADIFIPILPAIVTAGLLMGINNILTAEGIFFSTKSIVQVYPQWADLANMI NLIAGTAFTFLPALIGWSAVKRFGGNPLLGIVLGVMLVHPDLLNAWGYGAAEQSGEIP VWNLFGLEVQKVGYQGQVLPILLASYMLAKIEVFLTKRTPEGIQLLVVAPITLLLTGF ASFIIIGPITFAIGNVLTSGLISVFGSFAALGGLLYGGFYSALVITGMHHTFLAVDLQ LIGSKLGGTFLWPMLALSNIAQGSAALAMMFIVKDEKQKGLSLTSGISAYLGITEPAI FGVNLRYRFPFIIAMVSSGLAGMYISSQGVLASSVGVGGVPGIFSIMSQYWGAFAIGM AIVLIVPFAGTYAYARFKHK*" /label="treP CDS" gene 774592..776004 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /label="treP gene" promotor_no_box complement(774610..774710) /Source="Nicolas_upshift_promotors" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(774650) /Source="Nicolas_upshifts" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 776075..777760 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /EC_number="3.2.1.93" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651129, 7751281, 8755887, 8917076, 9701821, 26894535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651129, 7751281, 8755887, 8917076, 9701821, 26894535; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="trehalose-6-phosphate hydrolase" /protein_id="NP_388662.1" /db_xref="EnsemblGenomes-Gn:BSU07810" /db_xref="EnsemblGenomes-Tr:CAB12610" /db_xref="GOA:P39795" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR012769" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG11010" /db_xref="UniProtKB/Swiss-Prot:P39795" /translation="MKTEQTPWWKKAVVYQIYPKSFNDTTGNGVGDLNGIIEKLDYLK TLQVDVLWLTPIYDSPQHDNGYDIRDYYSIYPEYGTMEDFERLVSEAHKRDLKVVMDL VVNHTSTEHKWFREAISSIDSPYRDFYIWKKPQENGSVPTNWESKFGGSAWELDEASG QYYLHLFDVTQADLNWENEEVRKHVYDMMHFWFEKGIDGFRLDVINLISKDQRFPNAE EGDGRSFYTDGPRVHEFLHEMNEKVFSHYDSMTVGEMSSTTVDHCIRYTNPDNKELDM TFSFHHLKVDYPNGEKWALAPFDFLKLKEILSDWQTGMHAGGGWNALFWCNHDQPRVV SRYGDDGAYRVKSAKMLATAIHMMQGTPYIYQGEELGMTNPKFTDISSYRDVESLNMY HAFKEKGMADQDITAILQAKSRDNSRTPVQWDATENGGFTTGTPWIPVAGNYREINAE AALRDQNSVFYHYQKLIQIRKMYDIVTEGTYEIIAKDDPNIFAYLRHGSNEKLLVINN FYGTEAAFTLPDSLAPDEWKAEVLLTNDEAREGLQNMTLRPYESIVYRLTKPC*" /label="treA CDS" gene 776075..777760 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /label="treA gene" promotor_-10 complement(776381..776396) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(776388) /Source="Nicolas_upshifts" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(776409..776418) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 777733..777737 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 777753..777772 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 777756 /Source="Nicolas_upshifts" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="upshifts" CDS 777781..778497 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755887, 9829827, 17705272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755887, 9829827, 17705272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TreR-trehalose)" /protein_id="NP_388663.1" /db_xref="EnsemblGenomes-Gn:BSU07820" /db_xref="EnsemblGenomes-Tr:CAB12611" /db_xref="GOA:P39796" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR012770" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OGG" /db_xref="SubtiList:BG11011" /db_xref="UniProtKB/Swiss-Prot:P39796" /translation="MKVNKFITIYKDIAQQIEGGRWKAEEILPSEHELTAQYGTSRET VRKALHMLAQNGYIQKIRGKGSVVLNREKMQFPVSGLVSFKELAQTLGKETKTTVHKF GLEPPSELIQKQLRANLDDDIWEVIRSRKIDGEHVILDKDYFFRKHVPHLTKEICENS IYEYIEGELGLSISYAQKEIVAEPCTDEDRELLDLRGYDHMVVVRNYVFLEDTSLFQY TESRHRLDKFRFVDFARRGK*" /label="treR CDS" gene 777781..778497 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /label="treR gene" downshifts 778490 /Source="Nicolas_upshifts" /id="D387" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="6.58905" /MaxDrop="4.05981" /score="24.6748216" /energy="-11.1" /TU="U595,U598" /idTUdmin="U595" /TUdmin="-792" /isTUend="FALSE" /label="downshifts" promotor_-35 778572..778575 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 778591..778610 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 778600 /Source="Nicolas_upshifts" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="upshifts" CDS 778637..779302 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /EC_number="1.5.1.39" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15252706, 20727918, 20862523, 22238377, 26415543" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 20727918, 20862523, 22238377, 26415543; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H-flavin oxidoreductase (nitroreductase)" /protein_id="NP_388664.1" /db_xref="EnsemblGenomes-Gn:BSU07830" /db_xref="EnsemblGenomes-Tr:CAB12612" /db_xref="GOA:O34475" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="InterPro:IPR033878" /db_xref="SubtiList:BG12931" /db_xref="UniProtKB/Swiss-Prot:O34475" /translation="MADLKTQILDAYNFRHATKEFDPNKKVSDSDFEFILETGRLSPS SLGLEPWKFVVVQNPEFREKLREYTWGAQKQLPTASHFVLILARTAKDIKYNADYIKR HLKEVKQMPQDVYEGYLSKTEEFQKNDLHLLESDRTLFDWASKQTYIALGNMMTAAAQ IGVDSCPIEGFQYDHIHRILEEEGLLENGSFDISVMVAFGYRVRDPRPKTRSAVEDVV KWV*" /label="hypO CDS" gene 778637..779302 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /label="hypO gene" downshifts 779283 /Source="Nicolas_upshifts" /id="D388" /incds=0 /nref=180 /ntot=269 /MaxReadThrough="0.70079" /MaxDrop="6.77615" /score="34.5750428" /energy="-16.9" /TU="NA" /idTUdmin="U595" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(779339..783727) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /EC_number="3.1.4.16" /EC_number="3.1.3.5" /EC_number="3.1.3.6" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14688230, 16291680, 21800427, 21906378, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported 2',3'-cyclic-nucleotide 2'-phosphodiesterase, 2' (or 3') nucleotidase and 5' nucleotidase" /protein_id="NP_388665.1" /db_xref="EnsemblGenomes-Gn:BSU07840" /db_xref="EnsemblGenomes-Tr:CAB12613" /db_xref="GOA:O34313" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="PDB:3GVE" /db_xref="SubtiList:BG12930" /db_xref="UniProtKB/Swiss-Prot:O34313" /translation="MRIQKRRTHVENILRILLPPIMILSLILPTPPIHAEESAAPQVH LSILATTDIHANMMDYDYYSDKETADFGLARTAQLIQKHREQNPNTLLVDNGDLIQGN PLGEYAVKYQKDDIISGTKTHPIISVMNALKYDAGTLGNHEFNYGLDFLDGTIKGADF PIVNANVKTTSGENRYTPYVINEKTLIDENGNEQKVKVGYIGFVPPQIMTWDKKNLEG QVQVQDIVESANETIPKMKAEGADVIIALAHTGIEKQAQSSGAENAVFDLATKTKGID AIISGHQHGLFPSAEYAGVAQFNVEKGTINGIPVVMPSSWGKYLGVIDLKLEKADGSW KVADSKGSIESIAGNVTSRNETVTNTIQQTHQNTLEYVRKPVGKTEADINSFFAQVKD DPSIQIVTDAQKWYAEKEMKDTEYKNLPILSAGAPFKAGGRNGANYYTNIPAGDLAIK NVGDLYLYDNTVQIVKLTGSEVKDWLEMSAGQFNQIDPAKGGDQALLNENFRSYNFDV IDGVTYQVDVTKPAKYNENGKVINADSSRIINLSYEGKPISPSQEFLVVTNNYRASGG GGFPHLTSDKIVHGSAVENRQVLMDYIIEQKTVNPKADNNWSIAPVSGTNLTFESSLL AKPFADKADDVAYVGKSANEGYGVYKLQFDDDSNPDPPKDGLWDLTVMHTNDTHAHLD DAARRMTKINEVRSETNHNILLDAGDVFSGDLYFTKWNGLADLKMMNMMGYDAMTFGN HEFDKGPTVLSDFLSGNSATVDPANRYHFEAPEFPIVSANVDVSNEPKLKSFVKKPQT FTAGEKKEAGIHPYILLDVDGEKVAVFGLTTEDTATTSSPGKSIVFNDAFETAQNTVK AIQEEEKVNKIIALTHIGHNRDLELAKKVKGIDLIIGGHTHTLVDKMEVVNNEEPTIV AQAKEYGQFLGRVDVAFDEKGVVQTDKSNLSVLPIDEHTEENPEAKQELDQFKNELED VKNEKVGYTDVALDGQREHVRTKETNLGNFIADGMLAKAKEAAGARIAITNGGGIRAG IDKGDITLGEVLNVMPFGNTLYVADLTGKQIKEALEQGLSNVENGGGAFPQVAGIEYT FTLNNKPGHRVLEVKIESPNGDKVAINTDDTYRVATNNFVGAGGDGYSVFTEASHGED LGYVDYEIFTEQLKKLGNKVSPKVEGRIKEVFLPTKQKDGSWTLDEDKFAIYAKNANT PFVYYGIHEGSQEKPINLKVKKDQVKLLKERESDPSLTMFNYWYSMKMPMANLKTADT AIGIKSTGELDVSLSDVYDFTVKQKGKEIKSFKEPVQLSLRMFDIEEAHNPAIYHVDR KKKAFTKTGHGSVDDDMVTGYTNHFSEYTILNSGSNNKPPAFPSDQPTGGDDGNHGGG SDKPGGKQPTDGNGGNDTPPGTQPTNGSGGNGSGGSGTDGPAGGLLPDTATSMYSILL AGFLISALGTAMYLHQRRKQNRANQA*" /label="yfkN CDS" gene complement(779339..783727) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /label="yfkN gene" downshifts complement(779358) /Source="Nicolas_upshifts" /id="D389" /incds=0 /nref=155 /ntot=229 /MaxReadThrough="1.00159" /MaxDrop="7.08591" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U600" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(783760..783779) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(783777) /Source="Nicolas_upshifts" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(783794..783797) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 783904..783910 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 783924..783942 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 783927 /Source="Nicolas_upshifts" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="upshifts" CDS 783970..784488 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="general stress protein 18; deglycase" /protein_id="NP_388666.1" /db_xref="EnsemblGenomes-Gn:BSU07850" /db_xref="EnsemblGenomes-Tr:CAB12614" /db_xref="GOA:P80876" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12929" /db_xref="UniProtKB/Swiss-Prot:P80876" /translation="MGKKIAVVLTYYFEDSEYTEPAKAFKEAGHELTVIEKEKGKTVK GKQGTAEVTVDASIDDVNSSDFDALLIPGGFSPDQLRADDRFVQFTKAFMTDKKPVFA ICHGPQLLINAKALDGRKATGYTSIRVDMENAGADVVDKEVVVCQDQLVTSRTPDDIP AFNRESLALLEK*" /label="sufLB CDS" gene 783970..784488 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /label="sufLB gene" downshifts 784474 /Source="Nicolas_upshifts" /id="D390" /incds=0 /nref=35 /ntot=153 /MaxReadThrough="8.02255" /MaxDrop="6.97573" /score="42.2080398" /energy="-12.9" /TU="U601" /idTUdmin="U601" /TUdmin="-3542" /isTUend="FALSE" /label="downshifts" downshifts complement(784518) /Source="Nicolas_upshifts" /id="D391" /incds=0 /nref=22 /ntot=199 /MaxReadThrough="1.59285" /MaxDrop="3.61098" /score="31.1923457" /energy="-11.1" /TU="NA" /idTUdmin="U602" /TUdmin=10 /isTUend="TRUE" /label="downshifts" S_feature 784519..786169 /Source="Nicolas_S_feature" /locus_tag="new_860294_861944" /HighExp="Etha, S6, S8, S5, S7, Gly, Salt, LoTm, S4, Diami" /AntisenseName="yfkL" /AntisenseCor="-0.52109661167911703" /AntisenseRegPval="-19.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S273" CDS complement(784528..785718) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16828913, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux transporter" /protein_id="NP_388667.1" /db_xref="EnsemblGenomes-Gn:BSU07860" /db_xref="EnsemblGenomes-Tr:CAB12615" /db_xref="GOA:O34597" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12928" /db_xref="UniProtKB/Swiss-Prot:O34597" /translation="MQTTSIKTASGMYINYFFLGMVNIILASNMSSLTKQWNTDPTGI SYVIAAIGFGKLLTYGISGVLSDKIGRKPLVVASAGIMAVFLVGIPLSPSYELAFVFA LLAGVANSAMDAGTYPALTELFPSASGSANVLVKAFMSVGAALLPLLITFLADHSMFY GFAFYLPAAVYLLNIIYLSTLSFPKKHKKPTNSGQQESPVFLSEPVFQKEGTALIIIG FTSTALFTVSQIWLPSYAQKAAGLAESASVQLLSYYSIGSLASVLLLAVLLNRWVKPV FITLLYPIITLCTLAVMLTVHIPVVLDITAFFLGFSTAGVFQITITLMTELFWKRKGT VTGIVATASSLASILLPIATGLIAKAGGIAHIFIFDFGIAVIGTAAAAFLYYRYKKLT GAQA*" /label="yfkL CDS" gene complement(784528..785718) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /label="yfkL gene" S_feature complement(785719..785810) /Source="Nicolas_S_feature" /locus_tag="new_861494_861585_c" /HighExp="C90, MG 10, BMM, MG-0.2, MG t5, MG 5, MG-0.1, UNK1, HPh, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S274" CDS complement(785811..786026) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388668.1" /db_xref="EnsemblGenomes-Gn:BSU07870" /db_xref="EnsemblGenomes-Tr:CAB12616" /db_xref="InterPro:IPR009507" /db_xref="SubtiList:BG12927" /db_xref="UniProtKB/Swiss-Prot:O35019" /translation="MSSPNTETLTQMIEEISQKLNMLNVGVIKAEDFSDEKIEDLTYL HRMVMKKESFSPSEMQAIAQELASLRK*" /label="yfkK CDS" gene complement(785811..786026) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /label="yfkK gene" downshifts complement(785870) /Source="Nicolas_upshifts" /id="D392" /incds=0 /nref=1 /ntot=131 /MaxReadThrough="3.65318" /MaxDrop="2.45155" /score="16.183887" /energy="-11.6" /TU="U602" /idTUdmin="U602" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(786058..786077) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(786072) /Source="Nicolas_upshifts" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(786092..786093) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 786139..786146 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 786161..786180 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 786171 /Source="Nicolas_upshifts" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="upshifts" CDS 786229..786699 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /EC_number="3.1.3.48" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-tyrosine-phosphatase" /protein_id="NP_388669.1" /db_xref="EnsemblGenomes-Gn:BSU07880" /db_xref="EnsemblGenomes-Tr:CAB12617" /db_xref="GOA:O35016" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:4ETM" /db_xref="SubtiList:BG12926" /db_xref="UniProtKB/Swiss-Prot:O35016" /translation="MISVLFVCLGNICRSPMAEAIFRDLAAKKGLEGKIKADSAGIGG WHIGNPPHEGTQEILRREGISFDGMLARQVSEQDLDDFDYIIAMDAENIGSLRSMAGF KNTSHIKRLLDYVEDSDLADVPDPYYTGNFEEVCQLIKTGCEQLLASIQKEKQL*" /label="yfkJ CDS" gene 786229..786699 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /label="yfkJ gene" CDS 786717..787037 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388670.1" /db_xref="EnsemblGenomes-Gn:BSU07890" /db_xref="EnsemblGenomes-Tr:CAB12618" /db_xref="SubtiList:BG12925" /db_xref="UniProtKB/Swiss-Prot:O34418" /translation="MNNERLMLKGIFLGAAAGAALSLLHKPTRQACGMRWLTCKHKLS LYKSNPELLKNTVITKVDEAKKLARTLSKEVDFVNQQVKELKKTTPQVMELVQETKEH FSKK*" /label="yfkI CDS" gene 786717..787037 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /label="yfkI gene" CDS 787061..787888 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222749, 12794188, 15849754, 16850406, 15764599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease BN" /protein_id="NP_388671.1" /db_xref="EnsemblGenomes-Gn:BSU07900" /db_xref="EnsemblGenomes-Tr:CAB12619" /db_xref="GOA:O34437" /db_xref="InterPro:IPR017039" /db_xref="SubtiList:BG12924" /db_xref="UniProtKB/Swiss-Prot:O34437" /translation="MSFLKELFSRYTLHEGQSKSAELAYFFLLSLFPFLIFMLTLTAY LPLSTDDVLGVIEQYAPASAMSLVESITHQTLNNRNGGLLSFGIIAALWSASNGMNAI VRSLNHAYDVEENRSFIIVRLTSIFLTIAMVFTILVALLLPVFGREIGRLASDFVGAS DLFLSVWAAIRWGVSPLVLLIVFSALYVIAPNKKLSLRFVMPGAVFATIGWIIVSTLF SFYVSTFANYSATYGSIGGIIVLMIWFYLSGILIILGGEINALLHKRKKLPDENPYH* " /label="rbn CDS" gene 787061..787888 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /label="rbn gene" promotor_-35 787867..787873 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 787888..787899 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 787906..788062 /Source="Nicolas_S_feature" /locus_tag="new_863681_863837" /HighExp="S8, Etha, S6, Salt, S7, S5, ferm, nit, BT, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99976299999999996" /TUshortSig="SigGF, SigA, SigB" /TUshortPSig="0.974, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S275" upshifts 787906 /Source="Nicolas_upshifts" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(787938) /Source="Nicolas_upshifts" /id="D393" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.22239" /MaxDrop="3.61507" /score="-5.45682213" /energy="-3" /TU="NA" /idTUdmin="U606" /TUdmin=440 /isTUend="FALSE" /label="downshifts" downshifts 788037 /Source="Nicolas_upshifts" /id="D394" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="1.4253" /MaxDrop="6.85849" /score="25.8200126" /energy="-17.9" /TU="NA" /idTUdmin="U603" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(788087..789262) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388672.1" /db_xref="EnsemblGenomes-Gn:BSU07910" /db_xref="EnsemblGenomes-Tr:CAB12620" /db_xref="GOA:O34929" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12923" /db_xref="UniProtKB/Swiss-Prot:O34929" /translation="MSRFHFFILVLLVSISGFSQGMLLPVISIIFETNGESAAINGLH ATGLYIGVLLASPFMEAPLRKLGFKPLIVMGGSIVILSLFGFIWLQSVWVWFLLRLFI GIGDHMLHFSTQTWVTSMSSKQNRGRNLSIYGLSFGLGFAAGPFMVPLVKLSPSLPFI VSGCISLFAWLFVFFLQNAYPETSPHETKSDNSFRRFYQAMLFGWVAFMPTFGYGFLE TALNGSFPVYALRLGISVDAVAIILPAFAIGSIIFQFPLGILSDKYGRRNVLLVILLT GALCFFIAGVFPSPYVIGGCFFIAGMAVGSTFTLGISYMTDLLPPHLLPAGNLLCGIT FSLGSILGPVAGGWYMQTFESANLFYFITLTLSSVWLALVLGKPKSWSPAETYSSSS* " /label="yfkF CDS" gene complement(788087..789262) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /label="yfkF gene" downshifts complement(788092) /Source="Nicolas_upshifts" /id="D395" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="0.37084" /MaxDrop="3.28031" /score="3.2266059" /energy="-14.1" /TU="NA" /idTUdmin="U606" /TUdmin=286 /isTUend="FALSE" /label="downshifts" promotor_-35 788699..788705 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 788721..788739 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 788725..789378 /Source="Nicolas_S_feature" /locus_tag="new_864500_865153" /HighExp="Etha, M9-stat, Salt, Sw, Gly, B60, Heat, LPhT, HiTm, T0.30H" /AntisenseName="yfkF" /AntisenseCor="-0.18505347560608301" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S276" upshifts 788725 /Source="Nicolas_upshifts" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(789287..789306) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(789302) /Source="Nicolas_upshifts" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(789320..789327) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 789368..789373 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 789380 /Source="Nicolas_upshifts" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 789388..789406 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 789430..790485 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19543710, 23798403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19543710, 23798403; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+/Ca2+ antiporter" /protein_id="NP_388673.1" /db_xref="EnsemblGenomes-Gn:BSU07920" /db_xref="EnsemblGenomes-Tr:CAB12621" /db_xref="GOA:O34840" /db_xref="InterPro:IPR004713" /db_xref="InterPro:IPR004798" /db_xref="InterPro:IPR004837" /db_xref="PDB:4KJR" /db_xref="PDB:4KJS" /db_xref="SubtiList:BG12922" /db_xref="UniProtKB/Swiss-Prot:O34840" /translation="MNRIFFILVAAGVPLSVIGSLMHWPSAVLFAVYCVTIIALASYM GRATESLSIIAGPRIGGLLNATFGNAVELIISLFALKEGLTGIVLASLTGSVLGNLLL VAGLSFFVGGLKYKRQEFNIHDARHNSGLLIFAIIVAFVIPEVFSVGMGNASKLNLSI GISIIMILLYVAALYFKLVTHRGVYQPNNAAQTEEEEEPEWSGKVATIVLFAATIVVA YISENLVHTFHSVAEQFGWSELFIGVIIVAIVGNAAEHASAIIMAFKNKMDIAVEIAV GSTLQIAMFVAPVLVICSIFFPTSMPLVFTLPELVAMVSAVLLMIAISNDGDSNWFEG ATLLAAYVIMAIGFFLL*" /label="chaA CDS" gene 789430..790485 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /label="chaA gene" promotor_-35 790499..790505 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 790520..790531 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 790524 /Source="Nicolas_upshifts" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="upshifts" CDS 790556..791350 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19543710" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388674.1" /db_xref="EnsemblGenomes-Gn:BSU07930" /db_xref="EnsemblGenomes-Tr:CAB12622" /db_xref="InterPro:IPR025548" /db_xref="SubtiList:BG12921" /db_xref="UniProtKB/Swiss-Prot:O34579" /translation="MMKKLFHSTLIVLLFFSFFGVQPIHAKKQFKVPNSVASISKENT YPNASQDQPMLQPSKLAKELLDHSEVKIENPHLIKMLNESNISGTPLAVGYRATIFLG KWALGYESNETVANWEYKKINTNRADNRGGKETAEMHYAQEQQYRVKGGLTAKVPNAE DVKSMMMQKAMKKTNLPLAFETVIGAGTKRDQIYKVAPKKIGYLHAYAPAVNEKGKVT YGEVYLVLKGNKRKLVVKNVTSQGIGAWIPVQDHVTFGFQLSSLPR*" /label="yfkD CDS" gene 790556..791350 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /label="yfkD gene" downshifts 791338 /Source="Nicolas_upshifts" /id="D396" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="0.82657" /MaxDrop="5.7252" /score="28.7014976" /energy="-9.5" /TU="NA" /idTUdmin="U605" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(791389..792231) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17665170, 18310427, 19252899; Product type t: transporter" /codon_start=1 /transl_table=11 /product="mechanosensitive ion channel" /protein_id="NP_388675.1" /db_xref="EnsemblGenomes-Gn:BSU07940" /db_xref="EnsemblGenomes-Tr:CAB12623" /db_xref="GOA:O35043" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="SubtiList:BG12920" /db_xref="UniProtKB/Swiss-Prot:O35043" /translation="MRMKETLTEIFQNKIVDILLVAVILWIGVFIINRLVQLFFKRTD FIEEKKEKTIESLVRSVTQYTATIGFIFYVISLFVHDFGKILAGAGVAGIVIGFGAQS LIKDVLAGVFLIYERQLHKGDYVTVNNLFNGTVEEIGLRSLQIREWSGKLLTISNGEV RQIENYNIDFMRITESFLISFKEDPDRVYSVLEEACDMLNEELRDSLKRDEFGNPTEP FQIHGITALNKINRGVEFTVKGMVKDDDYFSASLAVRRVLVRQLYQNNVQMLEEAVRI ERTQ*" /label="mscC CDS" gene complement(791389..792231) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /label="mscC gene" downshifts complement(791391) /Source="Nicolas_upshifts" /id="D397" /incds=0 /nref=58 /ntot=230 /MaxReadThrough="1.96922" /MaxDrop="4.8789" /score="23.5281308" /energy="-9.8" /TU="NA" /idTUdmin="U609" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(792232..793353) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative Fe-S oxidoreductase, radical SAM superfamily" /protein_id="NP_388677.2" /db_xref="EnsemblGenomes-Gn:BSU07955" /db_xref="EnsemblGenomes-Tr:CAB12625" /db_xref="GOA:O34400" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014866" /db_xref="InterPro:IPR031004" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG12918" /db_xref="UniProtKB/Swiss-Prot:O34400" /translation="MTQNTKLRPITPEFDPWEAYMDVDQYGDMQLTNVEFTTTTLCNM RCEHCAVGYTLQPKDPNALPIDLLLKRLEEIPRLRSISITGGEPMLSLKSVKEYVVPL LKYAHERGVRTQINSNLTLDIERYEWIIPYLDVLHISHNWGTVEDFAEIGFAMMDRKP TFEQRARYFEKMIENSRTLVDAGVMVSAETMLNKRTLPHIEHIHRQITEDMKCQRHEV HPMYPSDFASALESLSLKEMRQAIHRLLDIRDENTWMLFGTLPFYACSPDEDDQKLLR RLRAAKNVTVRNDPDGRSRLNVNIFDGNIIVTDFGDTPPLGNIQTDSLPSAYEKWRET KLAKELSCHCPNVRCLGPNVLVKNSYYQDTDFTKRQARS*" /label="yfkA CDS" gene complement(792232..793353) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /label="yfkA gene" promotor_-10 complement(793394..793413) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(793412) /Source="Nicolas_upshifts" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(793429..793433) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 793441..793448 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 793462..793481 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 793472 /Source="Nicolas_upshifts" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="upshifts" CDS 793498..793683 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388678.1" /db_xref="EnsemblGenomes-Gn:BSU07970" /db_xref="EnsemblGenomes-Tr:CAB12626" /db_xref="SubtiList:BG12916" /db_xref="UniProtKB/Swiss-Prot:O35041" /translation="MGNAVNNKDQQIDYLKNRLDMFMNVIDSLDPEATDVEDIDRLIS MLDDLEAKYERFKKDWE*" /label="yfjT CDS" gene 793498..793683 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /label="yfjT gene" downshifts 793662 /Source="Nicolas_upshifts" /id="D398" /incds=0 /nref=15 /ntot=177 /MaxReadThrough="3.03457" /MaxDrop="3.24661" /score="14.1645187" /energy="-6.4" /TU="U610" /idTUdmin="U610" /TUdmin="-559" /isTUend="FALSE" /label="downshifts" promotor_-35 793726..793732 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 793738 /Source="Nicolas_upshifts" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 793747..793758 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 793784..794575 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 15687192" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 15687192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported peptidoglycan N-acetylmuramic acid deacetylase" /protein_id="NP_388679.1" /db_xref="EnsemblGenomes-Gn:BSU07980" /db_xref="EnsemblGenomes-Tr:CAB12627" /db_xref="GOA:O34928" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014235" /db_xref="PDB:1NY1" /db_xref="PDB:1W17" /db_xref="PDB:1W1A" /db_xref="PDB:1W1B" /db_xref="SubtiList:BG12915" /db_xref="UniProtKB/Swiss-Prot:O34928" /translation="MKWMCSICCAAVLLAGGAAQAEAVPNEPINWGFKRSVNHQPPDA GKQLNSLIEKYDAFYLGNTKEKTIYLTFDNGYENGYTPKVLDVLKKHRVTGTFFVTGH FVKDQPQLIKRMSDEGHIIGNHSFHHPDLTTKTADQIQDELDSVNEEVYKITGKQDNL YLRPPRGVFSEYVLKETKRLGYQTVFWSVAFVDWKINNQKGKKYAYDHMIKQAHPGAI YLLHTVSRDNAEALDDAITDLKKQGYTFKSIDDLMFEKEMRLPSL*" /label="pdaA CDS" gene 793784..794575 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /label="pdaA gene" downshifts 794573 /Source="Nicolas_upshifts" /id="D399" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.12067" /MaxDrop="3.4013" /score="14.4741934" /energy="-10.2" /TU="NA" /idTUdmin="U611" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(794613..795473) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative beta-hydroxyacid dehydrogenase" /protein_id="NP_388680.2" /db_xref="EnsemblGenomes-Gn:BSU07990" /db_xref="EnsemblGenomes-Tr:CAB12628" /db_xref="GOA:O34969" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12914" /db_xref="UniProtKB/Swiss-Prot:O34969" /translation="MKIAVIGLGNMGQPIARNVLQAGYELTVYNRTKQKTEDLVTEGA QAADTPRLAAKSADIVITMLADDDSVSTVTFGEDGLLEGLAENGIHISMSTISVEFSE KLAAAHAEKGQFFLAAPVLGRPDAAAKAALRIITAGPAEAKQAAKPLLDSLSQQIFDV GEESKTANAAKISINFLLVSMLEALSESFLMMEKYGLEQKQFLEIASALFGSPVYQNY GTIMAEQKFEPAGFKMSLGLKDTNLALAAAKRVSANLPLAELAKSHFESGIEKGFGDL DWAALIKCIK*" /label="yfjR CDS" gene complement(794613..795473) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /label="yfjR gene" downshifts complement(794627) /Source="Nicolas_upshifts" /id="D400" /incds=0 /nref=15 /ntot=193 /MaxReadThrough="2.61589" /MaxDrop="3.98341" /score="-1.3382901" /energy="-12.1" /TU="NA" /idTUdmin="U612" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(795493..795512) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(795507) /Source="Nicolas_upshifts" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(795528..795531) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(795572..796531) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563871, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="divalent cation (octahedral coordination) transporter" /protein_id="NP_388681.1" /db_xref="EnsemblGenomes-Gn:BSU08000" /db_xref="EnsemblGenomes-Tr:CAB12629" /db_xref="GOA:O31543" /db_xref="InterPro:IPR002523" /db_xref="InterPro:IPR004488" /db_xref="SubtiList:BG12913" /db_xref="UniProtKB/Swiss-Prot:O31543" /translation="MINITAITTEHQLLKNIPIERVEQPDIAWYWVDFYGPEDTETAL LRDFFHFHPLAIEDCFQHMQRPKLDHYDGYRFYVIHALNKETLETEEVDIFQGEKFVV TFHLHETPGIAKVRERLYASPDILKKGPGHISYMIMDQLVDEYFPLVYKIEDRLNEIE ESRPHKTYGTLMNEVFDLRTDLLHLRRTIIPMRDLLYRILSLDHVKEQRETKAYFSDI YDHLLKLSEIVESNRDMTSDLRDSYVTLNSNRMNAIMMTLTIVSTIFIPLTFIAGVYG MNFDFMPELHWKYGYFAVLGLMAALVIGMLIWFVHKGWFNIFK*" /label="yfjQ CDS" gene complement(795572..796531) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /label="yfjQ gene" downshifts complement(795595) /Source="Nicolas_upshifts" /id="D401" /incds=0 /nref=137 /ntot=224 /MaxReadThrough="2.29296" /MaxDrop="4.2496" /score="10.2736001" /energy="-7.5" /TU="NA" /idTUdmin="U613" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(796542..796561) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(796545) /Source="Nicolas_upshifts" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(796577..796580) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 796592..796596 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 796610..796629 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 796619 /Source="Nicolas_upshifts" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="upshifts" CDS 796650..797513 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /EC_number="3.2.2.21" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA-3-methyladenine glycosylase" /protein_id="NP_388682.1" /db_xref="EnsemblGenomes-Gn:BSU08010" /db_xref="EnsemblGenomes-Tr:CAB12630" /db_xref="GOA:O31544" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG12912" /db_xref="UniProtKB/Swiss-Prot:O31544" /translation="MWKEKVSVTPPYHFDRVLDRLSLDPLNAVDREAREVRVPIRNQA GDVCIVKVQALGHAGEPEFLVSGETDQGEMMKEIKRIFQWENHLQHVLDHFSKTSLSA IFEEHAGTPLVLDYSVYNCMMKCIIHQQLNLSFAYTLTERFVHAFGEQKDGVWCYPKP ETIAELDYQDLRDLQFSMRKAEYTIDTSRMIAEGTLSLSELPHMADEDIMKKLIKIRG IGPWTVQNVLMFGLGRPNLFPLADIGLQNAIKRHFQLDDKPAKDVMLAMSKEWEPYLS YASLYLWRSIE*" /label="yfjP CDS" gene 796650..797513 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /label="yfjP gene" S_feature 797514..797626 /Source="Nicolas_S_feature" /locus_tag="new_873289_873401" /HighExp="BC, M40t90, LBGtran, C90, M9-stat, M0t90, Lbtran, Sw, M40t45, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S277" CDS 797627..799027 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methyltransferase" /protein_id="NP_388683.1" /db_xref="EnsemblGenomes-Gn:BSU08020" /db_xref="EnsemblGenomes-Tr:CAB12631" /db_xref="GOA:O31545" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12911" /db_xref="UniProtKB/Swiss-Prot:O31545" /translation="MNQQKKQAPVELKVGQTFPLTIKRLGINGEGVGYFKKKVVFVPG ALPGEEVVVQATKVQPKFSEGRIKKIRKASEHRVAPPCPVYEQCGGCQLQHLAYSQQL REKRDIVIQSLERHTKFKVENMEIKETIGMDNPWNYRNKSQFQIGRSQSGSIIAGLYG LDSHDIVPIKDCIVQHPATNKTTGIVRRILEDFNVSVYNERKRKGDVRTIVTRVGFET GEVQVVLVTAKETLPHKEEIVKAIQKRLPEVKSIIQNVNGAKTSVIFGEKTKQLAGKT VIQEVLGDVSFELSARAFFQLNPEQTVKLYDEVKKAAQLTGKEKVVDAYCGVGTIGMW VADGAKEVRGMDVIKESIDDAKKNAKKHGMANATYVTGTAEHWLPKWTKEGFRPDVVI VDPPRTGCDSTFLDTIKKVKPKRFVYVSCNPSTLAKDLQTLSKDYRVDYIQPVDMFPQ TAHVEAVARLVLKSSN*" /label="yfjO CDS" gene 797627..799027 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /label="yfjO gene" downshifts 799039 /Source="Nicolas_upshifts" /id="D402" /incds=0 /nref=198 /ntot=251 /MaxReadThrough="1.18186" /MaxDrop="5.19313" /score="11.8630961" /energy="-12.6" /TU="NA" /idTUdmin="U614" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 799333..799340 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 799356..799375 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 799362 /Source="Nicolas_upshifts" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="upshifts" S_feature 799369..799652 /Source="Nicolas_S_feature" /locus_tag="new_875144_875427" /HighExp="M9-stat, T1.30H, T0.30H, T2.0H, LoTm, T3.0H, T3.30H, T1.0H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69102300000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S278" CDS 799653..799919 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097694.1" /db_xref="EnsemblGenomes-Gn:BSU08029" /db_xref="EnsemblGenomes-Tr:CAX52581" /db_xref="GOA:C0H3X6" /db_xref="InterPro:IPR025627" /db_xref="UniProtKB/Swiss-Prot:C0H3X6" /translation="MDKVYKRSWFQTFLAFLVSQLYFNFVELTGWGPKYREMNGFPAN IVELDFFQTYLSFYDNPWFNIITVFLGVFTIIQIITGITKDIRN*" /label="yfzA CDS" gene 799653..799919 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /label="yfzA gene" promotor_-10 complement(799867..799886) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(799885) /Source="Nicolas_upshifts" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(799901..799904) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 799920..800401 /Source="Nicolas_S_feature" /locus_tag="new_875695_876176" /HighExp="G180, Paraq, H2O2, G135, Oxctl, G150, C30, LoTm, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S279" promotor_-35 800372..800375 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 800392..800411 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 800403..800650 /Source="Nicolas_S_feature" /locus_tag="new_876178_876425" /HighExp="H2O2, G180, Paraq, G150, G135, Oxctl, dia15, LBGstat, LBGexp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S280" upshifts 800403 /Source="Nicolas_upshifts" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="upshifts" CDS 800651..801628 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /EC_number="1.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 25902496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase 2" /protein_id="NP_388684.1" /db_xref="EnsemblGenomes-Gn:BSU08030" /db_xref="EnsemblGenomes-Tr:CAB12632" /db_xref="GOA:O31546" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG12910" /db_xref="UniProtKB/Swiss-Prot:O31546" /translation="MTENFWRELPRPFFVLAPMEDVTDVVFRHVVSEAGRPDVFFTEF TNSESYCHPDGKDSVRGRLTFTEDEQPIVAHIWGDKPENFRKMSIGMAELGFKGLDIN MGCPVPNVAGNGKGSGLICRPAVAAELIQAAKAGGLPVSVKTRLGYTDVDEWREWLTH ILKQDIANLSIHLRTRAEMSKVDAHWELIPEIKKLRDEVAPDTLLTINGDIPDRQTGL KLAEQYGVDGIMIGRGIFTNPFAFEKEPKEHSSKELLDLLRLHLDLHDEYSKEEARPY KPLPRFFKIYLRGFRGASELRNQCMNTKSTDEVRALLDDFERKYLDGIE*" /label="dusC CDS" gene 800651..801628 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /label="dusC gene" S_feature 801629..801721 /Source="Nicolas_S_feature" /locus_tag="new_877404_877496" /HighExp="G135, G180, Paraq, G150, H2O2, LBGexp, aero, dia0, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S281" downshifts 801678 /Source="Nicolas_upshifts" /id="D403" /incds=0 /nref=86 /ntot=218 /MaxReadThrough="3.30163" /MaxDrop="4.0519" /score="11.8630961" /energy="-12.6" /TU="U617" /idTUdmin="U618" /TUdmin="-1211" /isTUend="FALSE" /label="downshifts" promotor_-35 801762..801768 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 801780..801799 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 801789 /Source="Nicolas_upshifts" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="upshifts" CDS 801824..802276 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388685.1" /db_xref="EnsemblGenomes-Gn:BSU08040" /db_xref="EnsemblGenomes-Tr:CAB12633" /db_xref="SubtiList:BG12909" /db_xref="UniProtKB/Swiss-Prot:O31547" /translation="MKRLCIIPCGKKKIWDVQPDAGPVRAEDAYLSPFHQACERYAKT FFDEWVILSAKHGFLRPDDLVSGNYDVTFGTGHPEIMTADELRRQFHEKGFSDIEELV MLGGKKYRSVLNAVIGEHQHISWPLSSYKGIGYMLQALNRAVEEKHEL*" /label="yfjM CDS" gene 801824..802276 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /label="yfjM gene" CDS 802306..802995 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388686.1" /db_xref="EnsemblGenomes-Gn:BSU08050" /db_xref="EnsemblGenomes-Tr:CAB12634" /db_xref="InterPro:IPR020523" /db_xref="SubtiList:BG11034" /db_xref="UniProtKB/Swiss-Prot:P40773" /translation="MKKLVFGLLAIVLFGCGLYIYHVWFGDPFSKNAAEQKLVSYVKQ TYPKKEIKITNGVYNAKTSEYVFEATSQSHRYPMCTKGFLHPKVTCDGIEEAYTESVA KHVNEEATKAIEADLKKAVPRFIKADAALSIENGQFTLDTKWNKKLAEKAPMSMTIQL DASGLSKTDAAKMAETVRKTLNEKGYTYSNGTIDCMQKDGDGGIGYVKYSIDFLSKAA IQSNDAEELGS*" /label="yfjL CDS" gene 802306..802995 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /label="yfjL gene" downshifts 803000 /Source="Nicolas_upshifts" /id="D404" /incds=0 /nref=31 /ntot=205 /MaxReadThrough="0.02745" /MaxDrop="3.61164" /score="23.9796437" /energy="-9" /TU="NA" /idTUdmin="U617" /TUdmin=1 /isTUend="TRUE" /label="downshifts" misc_feature 803172..803190 /Source="Nicolas_upshift_promotors" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 803179 /Source="Nicolas_upshifts" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="upshifts" CDS 803227..804228 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109, 22714279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109, 22714279; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent alpha subunit)" /protein_id="NP_388687.1" /db_xref="EnsemblGenomes-Gn:BSU08060" /db_xref="EnsemblGenomes-Tr:CAB12635" /db_xref="GOA:O31404" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12558" /db_xref="UniProtKB/Swiss-Prot:O31404" /translation="MKLLKREGLSLTEEKALWMYQKMLEIRGFEDKVHELFAQGVLPG FVHLYAGEEAVAVGVCAHLHDGDSITSTHRGHGHCIAKGCDLDGMMAEIFGKATGLCK GKGGSMHIADLDKGMLGANGIVGGGFTLACGSALTAKYKQTKNVSVCFFGDGANNQGT FHEGLNLAAVWNLPVVFVAENNGYGEATPFEYASACDSIADRAAAYNMPGVTVDGKDI LAVYQAAEEAIERARNGGGPSLIECMTYRNYGHFEGDAQTYKTKDERVEHLEEKDAIQ GFKNYLLKETDANKLSDIEQRVSESIEKAVSFSEDSPYPKDSELLTDVYVSYEKGGM* " /label="acoA CDS" gene 803227..804228 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /label="acoA gene" CDS 804232..805260 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 10368162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 10368162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent beta subunit)" /protein_id="NP_388688.1" /db_xref="EnsemblGenomes-Gn:BSU08070" /db_xref="EnsemblGenomes-Tr:CAB12636" /db_xref="GOA:O34591" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG12559" /db_xref="UniProtKB/Swiss-Prot:O34591" /translation="MARVISMSDAINEAMKLAMRKDENVLLIGEDVAGGAAVDHLQDD EAWGGVLGVTKGLVQEFGRTRVLDTPISEAGYMGAAMAAASTGLRPIAELMFNDFIGT CFDQVINQGAKFRYMFGGKAQVPITVRTTYGAGFRAAAQHSQSLYGLFTSIPGLKTVV PSNPYDAKGLLLAAIEDNDPVFFFEDKTSYNMKGEVPEDYYTIPLGKADIKREGNDVT LFAVGKQVNTALEAAAQLSERGIEAEVLDPRSLSPLDEDAIFTSLEKTNRLIIIDEAN PRCSIATDIAALVADKGFDLLDAPIKRITAPHTPVPFSPVLEDQYLPTPDKIVSVTLE LLGEPALN*" /label="acoB CDS" gene 804232..805260 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /label="acoB gene" CDS 805274..806470 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /EC_number="2.3.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E2 component (dihydrolipoamide acetyltransferase)" /protein_id="NP_388689.1" /db_xref="EnsemblGenomes-Gn:BSU08080" /db_xref="EnsemblGenomes-Tr:CAB12637" /db_xref="GOA:O31550" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG12560" /db_xref="UniProtKB/Swiss-Prot:O31550" /translation="MAVKVVMPKLGMAMKQGEVSIWNKKVGDPVEKGESIASIQSEKI EMEIEAPEKGTLIDIKVKEGEEVPPGTAICYIGDANESVQEEAGAPVAEDNMPQAVQP VKQENKPAASKKDRMKISPVARKIAEKAGLDLKQLKGTGPGGRIVKDDVTKALAEQKK DQAKPVSEQKAQEIPVTGMRKVIAARMQESLANSAQLTITMKADITKLATLQKQLSPT AEERYGTKLTITHFVSRAAVLALQAHPVLNSFYQNERIITHPHVHLGMAVALENGLVV PVIRHAEKLSLIELAQSISENAKKAREGRAGSEELQGSTFSITNLGAFGVEHFTPILN PPETGILGIGASYDTPVYQGEEIVRSTILPLSLTFDHRACDGAPAAAFLKAMKTYLEE PAALIL*" /label="acoC CDS" gene 805274..806470 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /label="acoC gene" downshifts complement(805275) /Source="Nicolas_upshifts" /id="D405" /incds=0 /nref=8 /ntot=46 /MaxReadThrough="0.481579999999999" /MaxDrop="4.16582" /score="-0.0231058321" /energy="-9.9" /TU="NA" /idTUdmin="U623" /TUdmin=4796 /isTUend="FALSE" /label="downshifts" CDS 806491..807867 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /EC_number="1.8.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase)" /protein_id="NP_388690.1" /db_xref="EnsemblGenomes-Gn:BSU08090" /db_xref="EnsemblGenomes-Tr:CAB12638" /db_xref="GOA:O34324" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12561" /db_xref="UniProtKB/Swiss-Prot:O34324" /translation="MTLAIIGGGPAGYAAAVSAAQQGRNVLLIDKGKLGGTCLNEGCI PTKSLLESANVLDKIKHADSFGIELPAGAISVDWSKMQSRKQQVVSQLVQGVQYLMKK NQIQVVKGTASFLSERKLLIEGENGKEIREADQVLIASGSEPIELPFAPFDGEWILDS KDALSLSEIPSSLVIVGGGVIGCEYAGLFARLGSQVTIIETADRLIPAEDEDIARLFQ EKLEEDGVEVHTSSRLGRVDQTAKTAIWKSGQREFKTKADYVLVAIGRKPRLDGLQLE QAGVDFSPKGIPVNGHMQTNVPHIYACGDAIGGIQLAHAAFHEGIIAASHASGRDVKI NEKHVPRCIYTSPEIACIGMTERQARSIYGDVKIGEFSFSANGKALIKQQAEGKVKIM AEPEFGEIVGVSMIGPDVTELIGQAAAIMNGEMTADMAEHFIAAHPTLSETLHEALLS TIGLAVHA*" /label="acoL CDS" gene 806491..807867 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /label="acoL gene" downshifts 807861 /Source="Nicolas_upshifts" /id="D406" /incds=0 /nref=27 /ntot=56 /MaxReadThrough="5.75671" /MaxDrop="5.6153" /score="27.0133719" /energy="-14.7" /TU="U619" /idTUdmin="U619" /TUdmin="-2156" /isTUend="FALSE" /label="downshifts" promotor_-35 807914..807921 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 807934..807953 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 807942 /Source="Nicolas_upshifts" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="upshifts" CDS 807983..809800 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /experiment="publication(s) with functional evidences, PMID:11274109, 16944132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 16944132; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AcoR-acetoin)" /protein_id="NP_388691.1" /db_xref="EnsemblGenomes-Gn:BSU08100" /db_xref="EnsemblGenomes-Tr:CAB12639" /db_xref="GOA:O31551" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG11790" /db_xref="UniProtKB/Swiss-Prot:O31551" /translation="MNSVPNDLQTWKRFVKDGVLDEARLRKRIAESWHRCKKAEVNPY LEKGPKVLQQTELDQQSKKHSFFLTTAKPYLEKLLPAIKEMEMMALLIDSDGVVLALD GHPRALYEAKRINFVEGACWTETAVGTNAIGTALHISEPVAIQGSEHYSIASHLWNCS AAPIHHEDGSLAGVIDISCPAAGAHPHMLGIATAIAYAAERELAAKSREKELELISRF GERAASSVPMVLCNTKQHIISASMPIRTSMPDWQGRHLYELKERGYSIENAVTIGDGG TCFYLSEQKKKKAFRFNGVIGQSGRSQAMLMHLERAAATDASVCLSGETGTGKEVAAR ALHENSERRHGPFVAVNCGAIPSDLIESELFGYAEGAFTGAKRNGYKGAFQKANQGTL FLDEIGEISHSMQVALLRVLQERKITPIGGTKEIPVDIRVIAATHCDLRELAENGKIR EDLFYRLHVYPIELPPLRDRTEDIPDLFEYYKQKNHWPGDLPSDFCNVLKQWKWPGNI RELFNVFERLSIRFPDGRLRDESLPALLEAAGLPASSAEKKPAAAGVLTFREQIQKDM MIKALESAKGNVSQAAKISGIPRSTFYKRLKKFNLSAES*" /label="acoR CDS" gene 807983..809800 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /label="acoR gene" promotor_-35 809801..809807 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 809819 /Source="Nicolas_upshifts" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 809822..809833 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 809854..810033 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_388692.1" /db_xref="EnsemblGenomes-Gn:BSU08110" /db_xref="EnsemblGenomes-Tr:CAB12640" /db_xref="GOA:O31552" /db_xref="InterPro:IPR012610" /db_xref="SubtiList:BG12917" /db_xref="UniProtKB/Swiss-Prot:O31552" /translation="MNIQRAKEIVESPDMKKVTYNGVPIYIQHVNEETGTARIYPLDE PQEEHEVQLNSLKED*" /label="sspH CDS" gene 809854..810033 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /label="sspH gene" downshifts 810017 /Source="Nicolas_upshifts" /id="D407" /incds=0 /nref=96 /ntot=181 /MaxReadThrough="1.9176" /MaxDrop="6.06509" /score="5.08326573" /energy="-12" /TU="NA" /idTUdmin="U619" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(810069..810398) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388693.1" /db_xref="EnsemblGenomes-Gn:BSU08120" /db_xref="EnsemblGenomes-Tr:CAB12641" /db_xref="GOA:O31553" /db_xref="InterPro:IPR003844" /db_xref="SubtiList:BG12908" /db_xref="UniProtKB/Swiss-Prot:O31553" /translation="MMLITILLFLAAGLAEIGGGYLVWLWLREAKPAGYGIAGALILI VYGILPTFQSFPSFGRVYAAYGGVFIVLAVLWGWLVDRKTPDLYDWIGAFICLIGVCV ILFAPRG*" /label="yfjF CDS" gene complement(810069..810398) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /label="yfjF gene" downshifts complement(810083) /Source="Nicolas_upshifts" /id="D408" /incds=0 /nref=96 /ntot=245 /MaxReadThrough="2.05328" /MaxDrop="6.2642" /score="34.1179702" /energy="-15.8" /TU="NA" /idTUdmin="U623" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS complement(810448..810906) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388694.1" /db_xref="EnsemblGenomes-Gn:BSU08130" /db_xref="EnsemblGenomes-Tr:CAB12642" /db_xref="GOA:O31554" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12907" /db_xref="UniProtKB/Swiss-Prot:O31554" /translation="MSEALTFESKYALLYLGGGLLAMIYGLITFFMAFPAFTSRGNVI FTIKTGPSGEIFLRKRSVLFSEVKRLYMGRHQYSLKGIFFEDIIIEKTDGKIVRIPTW NIITNPLFFEAVERYILPHLNEEAQNNWISQFTEVQRKAYLKEFENHPKL*" /label="yfjE CDS" gene complement(810448..810906) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /label="yfjE gene" S_feature complement(810907..810999) /Source="Nicolas_S_feature" /locus_tag="new_886682_886774_c" /HighExp="BI, BC, S2, Sw, HiOs, HiTm, S5, ferm, S4, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S282" CDS complement(811000..811557) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388695.1" /db_xref="EnsemblGenomes-Gn:BSU08140" /db_xref="EnsemblGenomes-Tr:CAB12643" /db_xref="GOA:O31555" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12906" /db_xref="UniProtKB/Swiss-Prot:O31555" /translation="MKNQEIIEVKSKMFLRIWAFVGSAGMGLACLWLFYMGITFQTKY YLLAIPAGFLFTLFCLYLFIIFFPAFTPRGNTIFRIKTGKNGEVFTDKVSVTFTDIKK IEMSRHKFSLKGIFQEDILIQTVDQKTIRIPTWNIIPNPLFFEAVERYILPHLNEEAK SNWIGQFTDIQRSAYLKEFENHPKL*" /label="yfjD CDS" gene complement(811000..811557) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /label="yfjD gene" promotor_-35 811423..811428 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 811436 /Source="Nicolas_upshifts" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 811443..811461 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 811447..812034 /Source="Nicolas_S_feature" /locus_tag="new_887222_887809" /HighExp="S4, S5, S6, S3, S8, S7, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="yfjC" /AntisenseCor="9.3643586039105595E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S283" CDS complement(811589..812356) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388696.1" /db_xref="EnsemblGenomes-Gn:BSU08150" /db_xref="EnsemblGenomes-Tr:CAB12644" /db_xref="SubtiList:BG12905" /db_xref="UniProtKB/Swiss-Prot:O31556" /translation="MKQFTISIEELLFCFYSEGFFEQGMALKQAYFPEIEDEQLGALF EAACRSLLAKDAAEYRNHQYRLKDEYCPFIHVLNDADYTVKLSKFNGQGAEQNVSCHV SKFGTYSHELLFDEQVHRITKMESSEGLLAKTDEFLHIIDTEDKRESIVTLTSNEFEK LLEGASDNPSYLKEFLEKHDHQEDVTRFANDLALRKGKMDTLMRLAYGKDNTPEVADM AFVLPGAHHTWLVTGITQNEFSILPAHKDVVNQIISK*" /label="yfjC CDS" gene complement(811589..812356) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /label="yfjC gene" CDS complement(812368..813591) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388697.1" /db_xref="EnsemblGenomes-Gn:BSU08160" /db_xref="EnsemblGenomes-Tr:CAB12645" /db_xref="SubtiList:BG12904" /db_xref="UniProtKB/Swiss-Prot:O31557" /translation="MSGNIAVDPDKLEQLANDVVTELTDMENKYKDLHVELGQMILQC DPRYSSCFSGVGDAWSSGKALVTKLSDNEIFIRKTGDKFVEQDDILRKLYNAYDKYGT MTSLTALMLTQGKYYGLGLTKFVKQPSGLHTAQHSKLLLDISRAVDSSRYQKAARVLL NPKYLLKKTNRPFSDLVHKKFTKYFPQDTVDFSNSVRSYTKGFLNEAGVRSTLKDVGK TGLRFAKGNAITATLITGATETFGAGVKIAENYAKYQDKPEVLKRENAKAVGNAVNNT IFVAGGATAGAVIGGAIGSFAGPVGTVLLGAAGSYIGGVVGEQIAKYTAGFAEKAALK LKEPIHAVVDTAKKGLESAGKVVKSVNDGIDAANKSIHKGIDSAKKGMEKAKKTADSL IHGATHFLKGKFSFG*" /label="yfjB CDS" gene complement(812368..813591) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /label="yfjB gene" CDS complement(813597..813911) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388698.1" /db_xref="EnsemblGenomes-Gn:BSU08170" /db_xref="EnsemblGenomes-Tr:CAB12646" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12903" /db_xref="UniProtKB/Swiss-Prot:O31558" /translation="MDSYKVIELANKYSAAAEEVRSSKMLLESRLSALGDAWQGKARD SFDQDFEETKAAYDQFEQELLETSQELKAAAVKIEERKAEIARMEELERKAREERHKL GR*" /label="yfjA CDS" gene complement(813597..813911) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /label="yfjA gene" promotor_-10 complement(813959..813978) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(813972) /Source="Nicolas_upshifts" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(813993..813996) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 814203..814222 /Source="Nicolas_upshift_promotors" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 814206 /Source="Nicolas_upshifts" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="upshifts" CDS 814247..815596 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /EC_number="3.2.1.122" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-alpha-glucosidase" /protein_id="NP_388699.1" /db_xref="EnsemblGenomes-Gn:BSU08180" /db_xref="EnsemblGenomes-Tr:CAB12647" /db_xref="GOA:P54716" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:1U8X" /db_xref="SubtiList:BG11839" /db_xref="UniProtKB/Swiss-Prot:P54716" /translation="MKKKSFSIVIAGGGSTFTPGIVLMLLDHLEEFPIRKLKLYDNDK ERQDRIAGACDVFIREKAPDIEFAATTDPEEAFTDVDFVMAHIRVGKYAMRALDEQIP LKYGVVGQETCGPGGIAYGMRSIGGVLEILDYMEKYSPDAWMLNYSNPAAIVAEATRR LRPNSKILNICDMPVGIEDRMAQILGLSSRKEMKVRYYGLNHFGWWTSIQDQEGNDLM PKLKEHVSQYGYIPKTEAEAVEASWNDTFAKARDVQAADPDTLPNTYLQYYLFPDDMV KKSNPNHTRANEVMEGREAFIFSQCDMITREQSSENSEIKIDDHASYIVDLARAIAYN TGERMLLIVENNGAIANFDPTAMVEVPCIVGSNGPEPITVGTIPQFQKGLMEQQVSVE KLTVEAWAEKSFQKLWQALILSKTVPNARVARLILEDLVEANKDFWPELDQSPTRIS* " /label="malA CDS" gene 814247..815596 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /label="malA gene" misc_feature 815625..815644 /Source="Nicolas_upshift_promotors" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 815627 /Source="Nicolas_upshifts" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="upshifts" CDS 815661..816425 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489864, 16707683, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489864, 16707683, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the Mal operon" /protein_id="NP_388700.1" /db_xref="EnsemblGenomes-Gn:BSU08190" /db_xref="EnsemblGenomes-Tr:CAB12648" /db_xref="GOA:P54717" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11847" /db_xref="UniProtKB/Swiss-Prot:P54717" /translation="MQLEELINQHYSKLNDNDFHILKYILNHKHTCYHLGIDALAKAC SVSRSSILRLAQKLGFSGYSEFRVFLKWEDQPEEGESMSFEKLLDDIEANLKFLRTKD MTDMCQLIDAADRIFVYGSGNAQKICARDLQRMFIPRHRYLILIEDTNEFNLMRDDFK VNDLFIIISLSGETPELIPQARMLSAKGIPFISITNLKNNVLAQLTPHNLYATSKPVT LSDRTEIVAFAPFFLVGEALFRAYVDYKEAEKNDNE*" /label="malR CDS" gene 815661..816425 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /label="malR gene" promotor_-10 complement(815805..815819) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(815835..815841) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(815835) /Source="Nicolas_upshifts" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 816440..818023 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) maltose-specificenzyme IICB component" /protein_id="NP_388701.1" /db_xref="EnsemblGenomes-Gn:BSU08200" /db_xref="EnsemblGenomes-Tr:CAB12649" /db_xref="GOA:P54715" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010975" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11848" /db_xref="UniProtKB/Swiss-Prot:P54715" /translation="MMQKIQRFGSAMFVPVLLFAFAGIIVGISTLFKNKTLMGPLADP DGFWYQCWYIIEQGGWTVFNQMPLLFAIGIPVALAKKAQARACLEALTVYLTFNYFVS AILTVWGGAFGVDMNQEVGGTSGLTMIAGIKTLDTNIIGAIFISSIVVFLHNRYFDKK LPDFLGIFQGSTYIVMISFFIMIPIALAVSYIWPMVQSGIGSLQSFLVASGAVGVWIY TFLERILIPTGLHHFIYTPFIYGPAVAEGGIVTYWAQHLGEYSQSAKPLKELFPQGGF ALHGNSKIFGIPGIALAFYVTAKKEKKKLVAGLLIPVTLTAIVAGITEPIEFTFLFIS PFLFAVHAVLAATMSTVMYMAGVVGNMGGGLIEAVTLNWIPLFGSHGMTYVYQILIGL SFTAIYFFVFRFLILKFNIATPGREKDEQQETKLYSKKEYRERKNKDETASAAETADD TAFLYIEALGGKDNITEVTNCATRLRVSVKDETKVEPDSVFRALGAHGVVRNGKAFQV IIGLSVPQMRERVEKILNQ*" /label="malP CDS" gene 816440..818023 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /label="malP gene" downshifts 818003 /Source="Nicolas_upshifts" /id="D409" /incds=0 /nref=23 /ntot=46 /MaxReadThrough="3.26652" /MaxDrop="4.69656" /score="8.65399085" /energy="-10.9" /TU="U624" /idTUdmin="U625" /TUdmin=836 /isTUend="FALSE" /label="downshifts" promotor_-35 818052..818059 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 818074..818093 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 818082 /Source="Nicolas_upshifts" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="upshifts" CDS 818129..819850 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative xenobiotic ABC transporter subunit (ATP-binding protein)" /protein_id="NP_388702.1" /db_xref="EnsemblGenomes-Gn:BSU08210" /db_xref="EnsemblGenomes-Tr:CAB12650" /db_xref="GOA:P54718" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11849" /db_xref="UniProtKB/Swiss-Prot:P54718" /translation="MQKALSFLKPYSLLAGIALILMLTELAVELMQPLLIAKIIDDGI LKQDLRHVWIWGTVMIGLTVLSFAAGMLNSFYAAHVSQSFSYDTRKGLFQKIQSFSYS TFGQFSSSSYITRLTNDVTQVQNMIFMSLRFMLRAPLMIAGGIVLSLAVNVKLGFFLL VTIPILILFLLWVLRKGGALFRSVQKRLDQVNTIMQENLIAIKLIKALLRGSHEVKRF IKANTRLMEKTVSAFQLVEFTMPVLMLLMNLCILLILWAGSYSITSGSTQVGDVVAII NYATRITGALSMFPFLIMIFTRAKASGDRIGEVLETEGDEREEGTISDRLSGRIEFQH VSFRYPEMDREALRNVSFSAKPRETIAILGATGSGKSTLFQLIPRLYQPDSGRIYIDE KPVQDIPAEGLRRQIGYVPQEVLLFSGTIKENIAWGKENASLDEIMDAAKLAQIHETI LKLPNGYDTVLGQRGVNLSGGQKQRISIARALIRKPAILLLDDSTSALDLQTEAKLLE AISTYHCTTLIITQKITTAMKADQILLLEDGELIEKGTHSELLSESQLYKRIYESQFG REGSESC*" /label="yfiB CDS" gene 818129..819850 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /label="yfiB gene" CDS 819844..821658 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388703.1" /db_xref="EnsemblGenomes-Gn:BSU08220" /db_xref="EnsemblGenomes-Tr:CAB12651" /db_xref="GOA:P54719" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11850" /db_xref="UniProtKB/Swiss-Prot:P54719" /translation="MLKDIRKPFQYPKLPIDKKEGAKKRAKAKDTKGTLRRIWSYLAE RKGLLILVMLMVVISAIFGLLGPFVIGKAIDHFIVGKTVSGLIPVLLLLLAIYIIQSL SLWFQNYWMITISQGTVFRMRSELFTHLHELPIPFFDKQRHGELMSRVTNDIENVSST LNTSVIQILSSVITFVGTIAVMLYMSPLLTLITLTIIPVMAASLKWITNRTGKLFKEQ QKNLGDLNGYIEESVSGAKVIKAYSREKQITAEFLEKNAALKTSGFWAQTISGFIPKV MNSLNNLSFTMIAAIGGLFALKGWISIGSIVVFAEYSRQFTRPLNDLANQFNTMLSAI AGAERVFDVLDEKEEREDEKNAVHQPIQTGSIEFRDVSFGYDKGQQTLKHLQFTVPAG QSIAFVGPTGAGKTTVTNLLARFYEPNDGKILIDGTDIKTLTRASLRKNMGFVLQDSF LFQGTIRENIRYGRLDASDQEVEAAAKTANAHSFIERLPKGYDTVLTQNGSGISQGQK QLISIARAVLADPVLLILDEATSNIDTVTEVNIQEALARLMEGRTSVIIAHRLNTIQR ADQIVVLKNGEMIEKGSHDELIRQKGFYSDLYESQFEK*" /label="yfiC CDS" gene 819844..821658 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /label="yfiC gene" downshifts 821633 /Source="Nicolas_upshifts" /id="D410" /incds=0 /nref=103 /ntot=190 /MaxReadThrough="2.4559" /MaxDrop="5.61906" /score="24.4395842" /energy="-11" /TU="NA" /idTUdmin="U627" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 821740..821747 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 821761..821780 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 821765 /Source="Nicolas_upshifts" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="upshifts" CDS 821813..822217 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16872404, 16850406, 17407181, 20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16872404, 16850406, 17407181, 20639328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase membrane subunit" /protein_id="NP_388704.1" /db_xref="EnsemblGenomes-Gn:BSU08230" /db_xref="EnsemblGenomes-Tr:CAB12652" /db_xref="GOA:P54720" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG11851" /db_xref="UniProtKB/Swiss-Prot:P54720" /translation="MNKSFEIGTLLLRVITGIIFFVHGLSKFQGMEGTIQFFGSIGLP SFMAYVIAAIELIGGVLVFFGLATRIVGVLFALTLIGAIITVKLKAPFMGNAEFDYLL LLTSIHLALTGSRFLALDPFVFKGKKNGNVSA*" /label="catD CDS" gene 821813..822217 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /label="catD gene" CDS 822235..823092 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17407181, 16872404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 16872404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase subunit" /protein_id="NP_388705.2" /db_xref="EnsemblGenomes-Gn:BSU08240" /db_xref="EnsemblGenomes-Tr:CAB12653" /db_xref="GOA:P54721" /db_xref="InterPro:IPR000486" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11852" /db_xref="UniProtKB/Swiss-Prot:P54721" /translation="MTSIHEDTHIGYAKLTIRSLERSLQFYCNVIGFQVLKKTDRQAE LTADGKRVLLILEENPSAVVLPERSVTGLYHFAILLPDRKELGIALARLIEHGIAIGH GDHAVSEALYLSDPDGNGIEMYADRPRSTWQRDREGNYVMTTTAVDIEGLLEEAGDER KTSLPNDTIIGHIHLHVSDLKEAKAFYTDVLGFDIVGNYAGMSALFVSAGGYHHHIGL NIWAGRNAPPKPTNASGLDYYTVVLPHQEELDLVANRVKHAGYSIEETENSFRVKDPV SGAYITFVI*" /label="catE CDS" gene 822235..823092 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /label="catE gene" downshifts 823079 /Source="Nicolas_upshifts" /id="D411" /incds=0 /nref=4 /ntot=21 /MaxReadThrough="0.66359" /MaxDrop="3.74886" /score="50.8573531" /energy="-19.7" /TU="NA" /idTUdmin="U628" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS 823186..824130 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family; cupin family)" /protein_id="NP_388706.1" /db_xref="EnsemblGenomes-Gn:BSU08250" /db_xref="EnsemblGenomes-Tr:CAB12654" /db_xref="GOA:P54722" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11853" /db_xref="UniProtKB/Swiss-Prot:P54722" /translation="MELNHLVTGKIALNQYVHRLEQKDVSFYVHYWGAMTNHYNTLLH KHSFYEICYVVRGEGYYLEGDRTYPLREQTIFLSKPEHLHQIKSETGLFLFYVAFELS EDQSSAEWIKVMEEVKQSPFITMQLKDGEPPGLLWKTLMLQAAQPVNAFDKEILSHLS HALILSLIQTFLPYAQRPKQKQPIHTSSALLTEVKLHIKDNLSQPLKLTDVASHFHIS GRHLSRLFAAELGVSYSEFVQNEKINKAAELLKSTNLSIKEIAEEIGFSVHYFTRVFS AKIGSSPGLFRSLYKDSKMTAFQINKPFQKIEQAKPHE*" /label="yfiF CDS" gene 823186..824130 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /label="yfiF gene" downshifts complement(823997) /Source="Nicolas_upshifts" /id="D412" /incds=1 /nref=1 /ntot=2 /MaxReadThrough="-0.20031" /MaxDrop="3.51831" /score="-4.19869956" /energy="-9.5" /TU="NA" /idTUdmin="U632" /TUdmin=9372 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(824045..824145) /Source="Nicolas_upshift_promotors" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(824085) /Source="Nicolas_upshifts" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 824305..825753 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar/proton transporter" /protein_id="NP_388707.1" /db_xref="EnsemblGenomes-Gn:BSU08260" /db_xref="EnsemblGenomes-Tr:CAB12655" /db_xref="GOA:P54723" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11854" /db_xref="UniProtKB/Swiss-Prot:P54723" /translation="MSTKKKEAVIGKESLAHKGLLRTITLVSTFGGLLFGYDTGVING ALPFMATAGQLNLTPVTEGLVASSLLLGAAFGAMFGGRLSDRHGRRKTILYLALLFIA ATLGCTFSPNASVMIAFRFLLGLAVGCASVTVPTFLAEISPAERRGRIVTQNELMIVI GQLLAYTFNAIIGSTMGESANVWRYMLVIATLPAVVLWFGMLIVPESPRWLAAKGRMG DALRVLRQIREDSQAQQEIKEIKHAIEGTAKKAGFHDFQEPWIRRILFIGIGIAIVQQ ITGVNSIMYYGTEILREAGFQTEAALIGNIANGVISVIAVIFGIWLLGKVRRRPMLII GQIGTMTALLLIGILSIVLEGTPALPYVVLSLTILFLAFQQTAISTVTWLMLSEIFPM HVRGLGMGISTFCLWTANFLIGFTFPILLNHIGMSATFFIFVAMNILAILFVKKYVPE TKGRSLEQLEHSFRQYGRRADQEIQNQTTHLS*" /label="yfiG CDS" gene 824305..825753 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /label="yfiG gene" CDS 825780..826721 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_388708.1" /db_xref="EnsemblGenomes-Gn:BSU08270" /db_xref="EnsemblGenomes-Tr:CAB12656" /db_xref="InterPro:IPR011418" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11855" /db_xref="UniProtKB/Swiss-Prot:P54724" /translation="MKLSYVTDSLGHLPFEDMLNFAAKLGIDTLEMTTGGWSPAPHLN LDELLQSSEKRKEFSQALEKRNMTLCALNCSGNPLDPGELGKSHRDITDKTMELAGLL GVKKVIMMSGLPAGGPDDKVPNWITYTVSWPPVLKDILNYQWEDVAIPYWKKLVKKAE ACGVGKIALENFSSQLVYNPETLFRLRNAVGPMVGLNLDPSHLLWMGADPIIAARELG SAIHHVHGKDVRIERYLSAVNGLLETKEVTDPANRAWNYVAVGCGQDLQWWKEFFSVV KMMGYEGEVSLEMEDLTMSPEAGIRTSVEALKQTISQ*" /label="yfiH CDS" gene 825780..826721 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /label="yfiH gene" CDS 826731..827912 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26438878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388709.1" /db_xref="EnsemblGenomes-Gn:BSU08280" /db_xref="EnsemblGenomes-Tr:CAB12657" /db_xref="GOA:P94437" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12214" /db_xref="UniProtKB/Swiss-Prot:P94437" /translation="MMLNGERIISKPLRWAMVGGGRLSQVGYKHRIGALRDNTAFQLT AGAFDIDAERGKDFGVNLGVDAERCYPNYQTMFAEEAKRQDGIEVVSIATPNGTHYEI CKAALEAGVHVICEKPLFFTSAEGQEIKALAEKKGKIVGVTYGFSGNQMLLQMRAMIE QGMIGDIRVVDLQYTHGFCATDEGEKISAAQKWRVDPAIAGPSFVLGDLSTHTYYMSQ LIMPKMKIKELLCDRQSFVGSRAPLEDNAHVLMHYENGAVGTMWTSSINAGCMDGHRI RIVGSKASIEWWDSKPNELTYEVQGEPGQTLVRGMPYLDDVCNADERLGALHSEGLSE AWANIYLKFAIAIDAKNREDEEILNNLVYPDIDAGIEGIRWIENCVRSANQGSVWVEF K*" /label="yfiI CDS" gene 826731..827912 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /label="yfiI gene" downshifts 827902 /Source="Nicolas_upshifts" /id="D413" /incds=0 /nref=40 /ntot=113 /MaxReadThrough="0.88387" /MaxDrop="5.80704" /score="14.819468" /energy="-13" /TU="NA" /idTUdmin="U630" /TUdmin="-2003" /isTUend="FALSE" /label="downshifts" promotor_-35 827972..827978 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 827993..828012 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 828011 /Source="Nicolas_upshifts" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="upshifts" CDS 828036..829238 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /function="16.12: Sense" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LinK] (linearmycin resistance, biofilm formation)" /protein_id="NP_388710.1" /db_xref="EnsemblGenomes-Gn:BSU08290" /db_xref="EnsemblGenomes-Tr:CAB12658" /db_xref="GOA:P94438" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12215" /db_xref="UniProtKB/Swiss-Prot:P94438" /translation="MKALFFTRMFTLMVSCLMYLSIVKEDNWFGYVFIAAGAAMYAAN HVLLTKETNAIWFCLIDIAIGFSFGFIFPGTGLFIIMLCPVAVAFFLRGFPKRTAWSV LCLSSILFLTVLIRTYAMFGNEFVIDHLTSMTFVVFCGVVGKLIRKLLDAQDTAKQQF QELTESHLALSAAHQELHLYAKQVEELTAIYERNRMAREIHDTVGHKMTALLVQLQLL REWQKRDSQKADETVGVCETLAREALDDVRLSVRTLQTENDPSLIESLKQLTEDFCKN AGVTTEFAVSGDPAIIPLSLHPTLIRTVQEALTNAKRHGGAAACSIQLACTTDSISLV IKDDGKGNPEAALGFGLLNMKKRAAEHGGMIRFESERDQGFTVNAEFSLANKKWSFGP VQQKESLS*" /label="linJ CDS" gene 828036..829238 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /label="linJ gene" CDS 829235..829897 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LinJ] (linearmycin resistance, biofilm formation)" /protein_id="NP_388711.1" /db_xref="EnsemblGenomes-Gn:BSU08300" /db_xref="EnsemblGenomes-Tr:CAB12659" /db_xref="GOA:P94439" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12216" /db_xref="UniProtKB/Swiss-Prot:P94439" /translation="MIKIIITDDQDIVREGLASLLQLREELDVIATARNGQEAFEKAK ELEPDIVLMDIRMPVSNGVEGTKLITSSLPSVKVLMLTTFKDSALIAEALEEGASGYL LKDMSADTIVKAVMTVHSGGMVLPPELTAQMLNEWKREKQLKGINEIEKPNELLDLTE REIEVLAELGYGLNNKEIAEKLYITEGTVKNHVSNIISKLAVRDRTQAAIYSVRYGVS VF*" /label="linK CDS" gene 829235..829897 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /label="linK gene" downshifts 829905 /Source="Nicolas_upshifts" /id="D414" /incds=0 /nref=114 /ntot=229 /MaxReadThrough="-0.0105699999999995" /MaxDrop="4.23231" /score="20.4785449" /energy="-7.6" /TU="NA" /idTUdmin="U630" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 830041..830976 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) biofilm formation" /protein_id="NP_388712.2" /db_xref="EnsemblGenomes-Gn:BSU08310" /db_xref="EnsemblGenomes-Tr:CAB12660" /db_xref="GOA:P94440" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12217" /db_xref="UniProtKB/Swiss-Prot:P94440" /translation="MLQAENIKKAYGKKTIVKGISFSLKKGESFGLLGPNGAGKSTTI SMISGLVPHDSGNITVGGYVIGKETAKAKQKIGIVPQEIALYPTLTAHENLMFWGKMY GLTHGEAKKRAAEVLEYVGLTERAKDKIETFSGGMKRRINIGAALMHKPELLIMDEPT VGIDPQSRNHILETVKQLNETGMTVIYTSHYMEEVEFLCDRIGIIDQGEMIAIGTKTD LCSRLGGDTIIQLTVSGINEAFLVAIRSLAHVNDVTVHELELKIDISAAHHEKVVTSL LAEATAHHINLLSLQVQEPNLERLFLNLTGRTLRD*" /label="bifL CDS" gene 830041..830976 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /label="bifL gene" CDS 830989..832179 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388713.1" /db_xref="EnsemblGenomes-Gn:BSU08320" /db_xref="EnsemblGenomes-Tr:CAB12661" /db_xref="GOA:P94441" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12218" /db_xref="UniProtKB/Swiss-Prot:P94441" /translation="MKKSIWIAWKDVKIRITDRKGFMMLILMPLILTCILGAALGSVV DGGSRIDDIKVGYIQSDQSDTANMFTKDVLKKMKSIKVTKVGSKDKMKKLIDEKKIDV GIVIPNHWEAGKTSAVVNAAPDQTLKSSIIETAASSFIEQYKAVKEAASGSMDYISKT EAVKQGKLDPAQFAEKLAKTLEKETGDKLTIAEKSVGSKAVTSFQYYSAAMLCMFMLF HITVGAKSFLQEKDTETLARMLMTPAQKSVILFGKWLGTYLFAIIQFFIFLIVTINVF GVDWGGNLLLVSVLGLSYAAAVSGISMLLASCISDMKTADAIGGFGIQLLAVLGGSML PLYQFPDVLQSVSKAVPNRWALDGFLSLMEGGGWADLQKPVLLFAAIGFCSLVIGIRR LHTR*" /label="bifM CDS" gene 830989..832179 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /label="bifM gene" CDS 832193..833350 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388714.1" /db_xref="EnsemblGenomes-Gn:BSU08330" /db_xref="EnsemblGenomes-Tr:CAB12662" /db_xref="GOA:P94442" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12219" /db_xref="UniProtKB/Swiss-Prot:P94442" /translation="MKKILAICGIELSLIFKKPQNYLIMFAAPLLLTFVFGSMLSGND DKVRLAIVDQDDTILSQHYIRQLKAHDDMYVFENMSESKASEKLKQKKIAGIIVISRS FQTQLEKGKHPELIFRHGPELSEAPMVKQYAESALATLNIQVTAAKTASQTAGENWKA AYKTVFAKKHEDIVPAVTRQTLSDKKEGAEASDTASRAAGFSILFVMLTMMGAAGTIL EARKNGVWSRLLTASVSRAEIGAGYVLSFFVIGWIQFGILLLSTHWLFGINWGNPAAV IVLVSLFLLTVVGIGLMIAANVRTPEQQLAFGNLFVIATCMVSGMYWPIDIEPKFMQS IAEFLPQKWAMSGLTEIIANGARVTDILGICGILLAFAAITFAAGLKALRA*" /label="bifN CDS" gene 832193..833350 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /label="bifN gene" promotor_-35 832304..832309 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 832324..832342 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 832325 /Source="Nicolas_upshifts" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(833348..833422) /Source="Nicolas_S_feature" /locus_tag="new_909123_909197_c" /HighExp="LoTm, Sw, C90, HiOs, BC, MG 45, UNK1, Fru, S1, BI" /AntisenseName="yfiN" /AntisenseCor="-6.3486715356968801E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S284" downshifts complement(833391) /Source="Nicolas_upshifts" /id="D415" /incds=0 /nref=90 /ntot=257 /MaxReadThrough="1.41433" /MaxDrop="6.01369" /score="13.7314837" /energy="-11.5" /TU="U632" /idTUdmin="U632" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(833423..833971) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of phenolic acid decarboxylase" /protein_id="NP_388715.1" /db_xref="EnsemblGenomes-Gn:BSU08340" /db_xref="EnsemblGenomes-Tr:CAB12663" /db_xref="GOA:P94443" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR018309" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12220" /db_xref="UniProtKB/Swiss-Prot:P94443" /translation="MRVLKYAILGLLRKGELSGYDITSYFKEELGQFWSAKHSQIYPE LKKLTDEGFITFRTTIQGTKLEKKMYTLTDSGKQELHDWLIRHQPIPETVKDEFMLKA YFISCLSRQEASDLFKDQLQKRQAKLSDLQGSYEKLMASAEPMSFSSPDFGHYLVLTK ALEREKNYVSWLESILAMIDKD*" /label="padR CDS" gene complement(833423..833971) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /label="padR gene" S_feature complement(833972..834051) /Source="Nicolas_S_feature" /locus_tag="new_909747_909826_c" /HighExp="LoTm, Cold, G180, GM-0.2, Oxctl, T5.0H, GM 25, T3.30H, MG 60, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S285" promotor_-10 complement(834040..834059) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(834051) /Source="Nicolas_upshifts" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(834073..834078) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 834174..834177 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 834193..834212 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 834200 /Source="Nicolas_upshifts" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="upshifts" CDS 834244..834876 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11029590, 10913700, 21574267" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11029590, 10913700, 21574267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted esterase / acylglycerol lipase" /protein_id="NP_388716.1" /db_xref="EnsemblGenomes-Gn:BSU08350" /db_xref="EnsemblGenomes-Tr:CAB12664" /db_xref="GOA:Q79F14" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11951" /db_xref="UniProtKB/Swiss-Prot:Q79F14" /translation="MKKVLMAFIICLSLILSVLAAPPSGAKAESVHNPVVLVHGISGA SYNFFAIKNYLISQGWQSNKLYAIDFYDKTGNNLNNGPQLASYVDRVLKETGAKKVDI VAHSMGGANTLYYIKYLGGGNKIQNVVTLGGANGLVSSTALPGTDPNQKILYTSIYSL NDQIVINSLSRLQGARNIQLYGIGHIGLLSNSQVNGYIKEGLNGGGLNTN*" /label="estB CDS" gene 834244..834876 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /label="estB gene" downshifts 834855 /Source="Nicolas_upshifts" /id="D416" /incds=0 /nref=7 /ntot=100 /MaxReadThrough="0.87881" /MaxDrop="2.6151" /score="0.223019698" /energy="-8.5" /TU="NA" /idTUdmin="U633" /TUdmin=88 /isTUend="FALSE" /label="downshifts" promotor_-35 834991..834996 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 835010..835029 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 835020 /Source="Nicolas_upshifts" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="upshifts" CDS 835065..836153 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 24776724, 25935415, 27303652; Product type t : transporter" /codon_start=1 /transl_table=11 /product="acetyl-glucosamine metabolite exporter componentinvolved in biofilm formation" /protein_id="NP_388717.1" /db_xref="EnsemblGenomes-Gn:BSU08360" /db_xref="EnsemblGenomes-Tr:CAB12665" /db_xref="GOA:O31559" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG12893" /db_xref="UniProtKB/Swiss-Prot:O31559" /translation="MQIKEIFMIRCISCLSVVLLHIISMVLMLQAEALADISHTVDSF RTLLMFSTPAFIFISEFLLARSYPDGVPDGFLKKRGKVIFVPFLFIAAIDALLMTSAM GGEVTFLAFVQKYLANVFLGNFIGYFILVIFQFYMLHMMFHEYLKKASPKWVLSISFV VTAAYLGYFSAASPAPASEEGGAFPFFWVPFAGWLFYFCLAYYCGKEYKRFLALLNQY RWVVYGAAIASGALVVTVSYVGEIGMISSKRPDIMLYSTSMIFLCFHLFSKMKHVPKI MMFISNYSFSIYLLHAYFMIIGYVLLLNMPEIPAVPAVLLLFAVCTAGPIMTSWALNK FKYGYLFVGKIYQPKQKKVTVEVRDHAG*" /label="icaC CDS" gene 835065..836153 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /label="icaC gene" S_feature complement(835555..835943) /Source="Nicolas_S_feature" /locus_tag="new_911330_911718_c" /HighExp="S6, S8, S7, S5, LBGstat, H2O2, Mt0, Cold, G180, LPhT" /AntisenseName="yfiQ" /AntisenseCor="0.36913176163336098" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.976" /TUlongSig="NA" /TUlongPSig="NA" /label="S286" upshifts complement(835943) /Source="Nicolas_upshifts" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(835945..835964) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(835977..835985) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(836189..836806) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16862575" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16862575; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388718.1" /db_xref="EnsemblGenomes-Gn:BSU08370" /db_xref="EnsemblGenomes-Tr:CAB12666" /db_xref="GOA:O31560" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1RKT" /db_xref="SubtiList:BG12894" /db_xref="UniProtKB/Swiss-Prot:O31560" /translation="MSPKVTKEHKDKRQAEILEAAKTVFKRKGFELTTMKDVVEESGF SRGGVYLYFSSTEEMFRRIIETGLDEGLRKLDKSAEHQSVWASISSYLDELTEGLRDV ADTLAPVQFEYLVTAWRNEERRQYLEKRYDLFVERFSRLLQKGIDQGEFQPVQPLATI AKFFLNMNDGIIQNALYFDEEKADVSGLAESAKLYLKTVLQADEK*" /label="yfiR CDS" gene complement(836189..836806) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /label="yfiR gene" downshifts complement(836207) /Source="Nicolas_upshifts" /id="D417" /incds=0 /nref=29 /ntot=209 /MaxReadThrough="2.44114" /MaxDrop="4.07715" /score="22.1532141" /energy="-17.1" /TU="NA" /idTUdmin="U636" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(836772..838025) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811639, 15849754, 16850406, 16862575; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388719.1" /db_xref="EnsemblGenomes-Gn:BSU08380" /db_xref="EnsemblGenomes-Tr:CAB12667" /db_xref="GOA:O31561" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12895" /db_xref="UniProtKB/Swiss-Prot:O31561" /translation="MEKPLFRNQKGLMTLLASQTISSLGDWLHILAVLTLAAFQLHAS PLDMSLLMMSFALPVIVLGPVSGLLADRFDRKTIMFLSEIGRALTVISCVYVSELWQL YVLLSVQSCFSSLFLPAKNGKLKELAPEAHIQQAVSVSSIIDNSSKIFGPALGGTLIA AFSIHSVFYINAGAFFLSAVILFFLPRDAFLQKANTPQEKTAALTSIKEGLQFLKRMP LLLTGLLTACVVLFVLQIGDSQAIILIRSFSGAPPELAGWCMAVSGAGMLLTAAITGR RRITSYLLYFSAGTLLLGLATGGAPFLSGMGIAGITLFIFAFFIMGAAFGLVHIPFQI LVQTTVPVDYSGRVFGAIQSATTLASILGMAGGGVLAEWIGVSLAFLVCGCLLIMIGL ITLIGKKIAESRRYLVTKSNKGAQG*" /label="yfiS CDS" gene complement(836772..838025) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /label="yfiS gene" promotor_-10 complement(836833..836852) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(836845) /Source="Nicolas_upshifts" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(836866..836873) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(838059..838078) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(838077) /Source="Nicolas_upshifts" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(838093..838100) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 838104..838123 /Source="Nicolas_upshift_promotors" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 838109 /Source="Nicolas_upshifts" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="upshifts" CDS 838149..838685 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15581359, 22059487, 24821014, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15581359, 22059487, 24821014, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol S-transferase" /protein_id="NP_388720.1" /db_xref="EnsemblGenomes-Gn:BSU08390" /db_xref="EnsemblGenomes-Tr:CAB12668" /db_xref="GOA:O31562" /db_xref="InterPro:IPR023774" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="PDB:1RXQ" /db_xref="SubtiList:BG12896" /db_xref="UniProtKB/Swiss-Prot:O31562" /translation="MTSVNLSYPIGEYKPRESISKEQKDKWIQVLEEVPAKLKQAVEV MTDSQLDTPYRDGGWTVRQVVHHLADSHMNSYIRFKLSLTEETPAIRPYDEKAWSELK DSKTADPSGSLALLQELHGRWTALLRTLTDQQFKRGFYHPDTKEIITLENALGLYVWH SHHHIAHITELSRRMGWS*" /label="bstA CDS" gene 838149..838685 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /label="bstA gene" CDS complement(838682..840238) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388721.1" /db_xref="EnsemblGenomes-Gn:BSU08400" /db_xref="EnsemblGenomes-Tr:CAB12669" /db_xref="GOA:O31563" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12897" /db_xref="UniProtKB/Swiss-Prot:O31563" /translation="MSEALTEQKSQKWAISLFTIGVFMAALDNGIISAALTTINESFS VSPSWGSWGITLYTLGLSVSVPIVGKLSDRYGRKKLFLIEVCLFGLGSLLVALSQSFP LFLISRLIQALGGGGIFIIGSSHILATLPKEKQGKALGLLGAMNGMAAVLGPNIGSFL LDWTGSWHWLFLINLPIAVLLVVFGACFIAETKAPEAKRLDAAGIFLLSLSILAVMYG MTNLDGANLLHSLGNPEVYGCIIFGILCFAALISYEKRVEMRGGDPILAYSLLRNHMF QRTLIIGLLSGGLLAAVIFIPSYVEQYLGVPAAKAGYWMTPLALASGIGAWLGGALTD KKGPVKTVILSGIISCAGFALFPLWVTEKWEFVIASVAAGIGFGFLLGAPLNVLVSEA AKTNKGTALGTLSLVRQIGLTLAPTLYAGFITAGFDQIGDEINSRLSDSGYSEKAMQM IPEIDSSEVSSLQEQIERIPVPEVKTAISDAIHASVASGYDHLYAAAAVVSLLVIAAI SIPAFRRQKR*" /label="yfiU CDS" gene complement(838682..840238) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /label="yfiU gene" promotor_-10 complement(840260..840278) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(840277) /Source="Nicolas_upshifts" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(840294..840297) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(840349..840831) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18990441; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388722.1" /db_xref="EnsemblGenomes-Gn:BSU08410" /db_xref="EnsemblGenomes-Tr:CAB12670" /db_xref="GOA:O31564" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12898" /db_xref="UniProtKB/Swiss-Prot:O31564" /translation="MEYNLHDTTVLNENILSSEEREIWVLYMKVLTSAGLGDVSEWMK LDMSMPQMKVLMLLNNHGTLKVSDIAEKMGASLSNTTGLLDRLEKSGFVKRSHSEEDR RSVVVQLTENAKKIFRGLYEKGHLKLKRSLELLSPEEKQAVYEGLSILSRALENAKKE *" /label="yfiV CDS" gene complement(840349..840831) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /label="yfiV gene" downshifts complement(840365) /Source="Nicolas_upshifts" /id="D418" /incds=0 /nref=58 /ntot=177 /MaxReadThrough="1.47849" /MaxDrop="4.15907" /score="27.2704527" /energy="-14.2" /TU="NA" /idTUdmin="U640" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(840856..840875) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(840872) /Source="Nicolas_upshifts" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(840890..840896) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 840917..840924 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 840938..840957 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 840946 /Source="Nicolas_upshifts" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="upshifts" CDS 841003..843573 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /EC_number="2.3.2.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol lysyltransferase involved in tRNA-dependent lysinylation of phospholipids" /protein_id="YP_003097695.1" /db_xref="EnsemblGenomes-Gn:BSU08425" /db_xref="EnsemblGenomes-Tr:CAX52582" /db_xref="GOA:C0H3X7" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022791" /db_xref="InterPro:IPR024320" /db_xref="UniProtKB/Swiss-Prot:C0H3X7" /translation="MLIKKNALSILKIVFPIAVLLFVIYQSKKELTNLSFKRTLMVIN GLERTDLFMLVLIGLLAVAAMSLYDYVLKYSLRLSITNGKVFRVSWIANSFNNVLGFG GLAGVGLRMMFYKEHTKDHKALVKGIAWLTSSMLLGLSVFSIFVAARVLPVDEVIHEK PWLWAVVIGFALILPLSLAVSKIKDRKAGDEENADKVKNPIFAYIGASVVEWLMAGTV IYFALFAMGIHADIRYVFGVFVIAAIGGMISLVPGGFGSFDLLFLLGMEQLGYHQEAI VTSIVLYRLAYSFIPFILGLFFAAGDLTENTMKRLETNPRIAPAIETTNVLLVVQRAV LVRILQGSLSLIVFVAGLIVLASVSLPIDRLTVIPHIPRPALLLFNGLSLSSALILLI LPIELYKRTKRSYTMAITALVGGFVFSFLKGLNISAIFVLPMIIVLLVLLKKQFVREQ ASYTLGQLIFAVALFTVALFNYNLIAGFIWDRMKKVLRHEYFVHSTSHITHATIMAII IVPLFFLIFTVVYHKRTKPIGEKADPERLAAFLNEKGGNALSHLGFLGDKRFYFSSDG NALLLFGKIARRLVVLGDPSGQRESFPLVLEEFLNEAHQKGFSVLFYQIEREDMALYH DFGYNFFKLGEEAYVDLNTFTLTGKKKAGLRAINNRFEREEYTFHVDHPPFSDAFLEE LKQISDEWLGSKKEKGFSLGFFDPSYLQKAPIAYMKNAEGEIVAFANVMPMYQEGEIS VDLMRYRGDAPNGIMDALFIRMFLWAKEEGCTSFNMGMAPLANVGTAFTSFWSERFAA VIFNNVRYMYSFSGLRAFKEKYKPEWRGKYLAYRKNRSLSVTMFLVTRLIGKSKKDSV *" /label="mprF CDS" gene 841003..843573 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /label="mprF gene" downshifts 843544 /Source="Nicolas_upshifts" /id="D419" /incds=0 /nref=121 /ntot=252 /MaxReadThrough="1.79352" /MaxDrop="5.78159" /score="49.2396824" /energy="-16.1" /TU="NA" /idTUdmin="U641" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(843591..844568) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 19254027, 24606332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter binding lipoprotein" /protein_id="NP_388725.1" /db_xref="EnsemblGenomes-Gn:BSU08440" /db_xref="EnsemblGenomes-Tr:CAB12673" /db_xref="GOA:O31567" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12901" /db_xref="UniProtKB/Swiss-Prot:O31567" /translation="MKKHISMLFVFLMAVMVLSACNSSESSSNSEVSSSKTRTVKHAM GTSDNIPANPKRIVVLTNEGTEALLALGIKPVGAVKSWKGDPWYDYLKDDMKGVKNVG LETEPNVEAIAELKPDLIIGNKVRQEKIYDQLNAIAPTVFAESLAGNWKDNLTLYANA VNKADKGKEVIADFDKRVSDLKNKLGDQTNKTVSVVRFLSGESRIYYTDSFPGIILDQ LGFKRPEKQVELFKKQKDQFTFSTDSKESIPDMDADVLFYFTYKADNAKENEKWANQW TSSSLWKNLKAVKSGNAHEVDDVVWTTAGGIKAANYLLDDIETYFLKTK*" /label="sxzY CDS" gene complement(843591..844568) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /label="sxzY gene" downshifts complement(843602) /Source="Nicolas_upshifts" /id="D420" /incds=0 /nref=165 /ntot=248 /MaxReadThrough="1.28876" /MaxDrop="7.70135" /score="35.2605181" /energy="-16.1" /TU="NA" /idTUdmin="U643" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 844583..844590 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(844595..844614) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 844605..844624 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 844607..844698 /Source="Nicolas_S_feature" /locus_tag="new_920382_920473" /HighExp="dia0, Lbexp, LBGexp, H2O2, G150, GM 10, Oxctl, dia15, Paraq, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S287" upshifts 844607 /Source="Nicolas_upshifts" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(844612) /Source="Nicolas_upshifts" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(844629..844636) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-35" CDS 844699..845700 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388726.1" /db_xref="EnsemblGenomes-Gn:BSU08450" /db_xref="EnsemblGenomes-Tr:CAB12674" /db_xref="GOA:O31568" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12902" /db_xref="UniProtKB/Swiss-Prot:O31568" /translation="MICKKASSKWIVLVCLIFILLTAVCASVVYGYTGTSWRQVYQAF TSFNGTNEHVIIKDVRLPRALVATVVGASLAAAGALMQALTKNPLASPGIFGINAGAG FFIVAGSFFLHIQSPQALVWSSFLGAAFTAAIVYAAGSLGREGLTPIKLTLAGAAMAA MFSSLTQGLLSVNELELAQVLFWLTGSVQGRSLDLLMTMFPYAAAALVICFFLGQKIN LLVMGEDVAKGLGQKTGLLKFVMALCVVMLAGSAVAIAGPISFIGIIIPHFARFVVGN DYRWVLPFSAVLGAILLVCADIGARYIIMPQEVPVGVMTAIIGMPVFVYIARRGAKL* " /label="sxzZ CDS" gene 844699..845700 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /label="sxzZ gene" CDS 845697..846728 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388727.1" /db_xref="EnsemblGenomes-Gn:BSU08460" /db_xref="EnsemblGenomes-Tr:CAB12675" /db_xref="GOA:O31569" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12876" /db_xref="UniProtKB/Swiss-Prot:O31569" /translation="MKLRFGVTAAEKKAWIVFLVLLGLTAAVLIISAGLGQRFIPPWD VAKTFFGAGSKLDELMIMSFRMPRILTALCAGVCLAAAGAILQGLVRNPLASPDIIGI TGGAAVAVVLLMMFFSDRSSSLTISLSWLPAAAFIGASAVGLIVYLLAYKNGASTFRL VLIGIGFSMSAQAMTTLLMIKGPIYRASQANVYITGSVYGSNWQHVKIAIILSVILLF ICFVALKNMNIQVLGEDIAAGAGSAVQRNRFFLLLLSTALTGCAVSVAGTIGFVGLMA PHIARRLVGSSYGALLPASALIGALLVLTADIVGRTLFAPVEVPAGVFTAAIGAPYFI YLLYKTRNS*" /label="sxzA CDS" gene 845697..846728 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /label="sxzA gene" downshifts 846709 /Source="Nicolas_upshifts" /id="D421" /incds=0 /nref=24 /ntot=154 /MaxReadThrough="3.26686" /MaxDrop="4.27732" /score="19.6751667" /energy="-12.8" /TU="NA" /idTUdmin="U642" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 846779..846781 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 846797..846816 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 846800 /Source="Nicolas_upshifts" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="upshifts" CDS 846843..847724 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /EC_number="5.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative isomerase" /protein_id="NP_388728.1" /db_xref="EnsemblGenomes-Gn:BSU08470" /db_xref="EnsemblGenomes-Tr:CAB12676" /db_xref="GOA:O31570" /db_xref="InterPro:IPR003719" /db_xref="SubtiList:BG12877" /db_xref="UniProtKB/Swiss-Prot:O31570" /translation="MKEAEVLKYEAFTSSPGKGNPAGVVLQGDDYTEDEMQIIAERAG YSETSFIRKSESADLELRYFTPGHEMNLCGHATVASLYALCEKGMLESGKTYSIQTKA GILPVKISEKDGRIHITLEQASPQFKPFTGDRKKLADALGITDEDFHEDLPIVFGSTG IWTAIVPLKSLEASKKMVPDNKQFPEVLVDLPKASVHPFTFETVHPDSDLHGRHFSSP YSGTIEDPVTGTASGVMGAYMKHYGNAEQHKFIIEQGQEIGKDGKVEIEMNEAGGHVK VNMTGTAVYSETRILKI*" /label="yfhB CDS" gene 846843..847724 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /label="yfhB gene" promotor_-35 847735..847742 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 847758..847777 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 847767 /Source="Nicolas_upshifts" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="upshifts" CDS 847812..848396 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 22287527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (nitroreductase family)" /protein_id="NP_388729.1" /db_xref="EnsemblGenomes-Gn:BSU08480" /db_xref="EnsemblGenomes-Tr:CAB12677" /db_xref="GOA:O31571" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR026021" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG12878" /db_xref="UniProtKB/Swiss-Prot:O31571" /translation="MPQTEQIHQHSVLRDIIRSRRSIRKFKQEPVPSAVILDMLETAK YAPNHRVTEPWRFIYVSSETGKANLINTFAAFSKKSKPDMTEEKLQNFKNTLGRVPGF LLVVFQEDENERARDDDFAATSSLIQNLQLLAWEKGIGMVWKSGKILYDKEVHQAFGL QDNERFAAIIQTGYPDEAPEVKKRTPIRDRFTEM*" /label="yfhC CDS" gene 847812..848396 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /label="yfhC gene" downshifts 848383 /Source="Nicolas_upshifts" /id="D422" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="3.27483" /MaxDrop="6.40857" /score="21.7703837" /energy="-18.2" /TU="U645" /idTUdmin="U644" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(848435..848626) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388730.1" /db_xref="EnsemblGenomes-Gn:BSU08490" /db_xref="EnsemblGenomes-Tr:CAB12678" /db_xref="InterPro:IPR025435" /db_xref="SubtiList:BG12879" /db_xref="UniProtKB/Swiss-Prot:O31572" /translation="MGRNHIHKNRDKNKQKLPQVPDALKRETDGVYEEYSTELADADD REAQERAKAADNRAKKKSR*" /label="yfhD CDS" gene complement(848435..848626) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /label="yfhD gene" downshifts complement(848453) /Source="Nicolas_upshifts" /id="D423" /incds=0 /nref=65 /ntot=197 /MaxReadThrough="0.436919999999999" /MaxDrop="8.51174" /score="30.1998663" /energy="-18.2" /TU="NA" /idTUdmin="U649" /TUdmin=7 /isTUend="TRUE" /label="downshifts" upshifts complement(848658) /Source="Nicolas_upshifts" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(848661..848672) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(848687..848693) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(848693..848803) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388731.1" /db_xref="EnsemblGenomes-Gn:BSU08500" /db_xref="EnsemblGenomes-Tr:CAB12679" /db_xref="InterPro:IPR025437" /db_xref="SubtiList:BG12880" /db_xref="UniProtKB/Swiss-Prot:O31573" /translation="MEKKREKHQQGANLKKMQEVLYSGEFKKAEKAAKRK*" /label="yfhE CDS" gene complement(848693..848803) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /label="yfhE gene" promotor_-10 complement(848832..848843) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(848834) /Source="Nicolas_upshifts" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(848858..848864) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(848858..849769) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotide-or NAD-binding protein" /protein_id="NP_388732.1" /db_xref="EnsemblGenomes-Gn:BSU08510" /db_xref="EnsemblGenomes-Tr:CAB12680" /db_xref="GOA:O31574" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR010099" /db_xref="InterPro:IPR013549" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12881" /db_xref="UniProtKB/Swiss-Prot:O31574" /translation="MNIAMTGGTGFLGQHLTGVLTRQGHHVYILSRNARETEQKNMTY VQWLSEGAAPEQELPHIDVWINLAGKSIFGRWTEKTKQHILSSRINATREVQRLIQKQ KEKPKTLIQASAVGIYGTSLEKTFTEDSATSDEDFLSHTAHLWEKEGQHIEAMGIRTV YARFGVMLGEKGALPLMILPYKFLAGGTIGTGRQWLSWIHVEDAAQMIRYAVENAGIS GPMNVTAPNPVDMKQFGKTIARVKHRPHWLPVPEFFLSKALGEMSLLIVKGQRALPKK AITSGFRFTYSDLEFALSQLIADRKTV*" /label="yfhF CDS" gene complement(848858..849769) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /label="yfhF gene" promotor_-35 849655..849658 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 849675..849694 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 849685..849857 /Source="Nicolas_S_feature" /locus_tag="new_925460_925632" /HighExp="LBGstat, Lbtran, T1.30H, T2.0H, T2.30H, M9-stat, T1.0H, T3.0H, Sw, G180" /AntisenseName="yfhF" /AntisenseCor="-5.3501479327985699E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S288" upshifts 849685 /Source="Nicolas_upshifts" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(849791..849809) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(849805) /Source="Nicolas_upshifts" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(849823..849829) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 849858..850652 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /function="16.3: Control" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8946165, 10869079, 12547390, 23284295, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8946165, 10869079, 12547390, 23284295, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulatory protein RecX" /protein_id="NP_388733.1" /db_xref="EnsemblGenomes-Gn:BSU08520" /db_xref="EnsemblGenomes-Tr:CAB12681" /db_xref="GOA:O31575" /db_xref="InterPro:IPR003783" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12882" /db_xref="UniProtKB/Swiss-Prot:O31575" /translation="MPFITKISTQKKNTERFNIFLDDKYAFSVDADVLVKFELKKGKE LDDLDIIEIQYGDEVKKGFNRALDFLSYRMRSTKEVEDHLKKKETSPPVIAEVIHRLN DYKYLNDQEFAAAYVSTHKKTNGKGPDVLFRELRAKGIDDDTIKEALSSFSFEDQTRE AVKHVEKLLKKDKKLSTKELKQRAQLQLQRKGFSFDVISAAMDQIEYENDEDTEKEAL RLHAEKAFRKYRYDGSYESAMKVKQFLFRKGFSLDLIEQLLQEEEY*" /label="recX CDS" gene 849858..850652 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /label="recX gene" CDS 850654..850968 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388734.1" /db_xref="EnsemblGenomes-Gn:BSU08530" /db_xref="EnsemblGenomes-Tr:CAB12682" /db_xref="InterPro:IPR014938" /db_xref="InterPro:IPR036289" /db_xref="PDB:1SF9" /db_xref="SubtiList:BG12883" /db_xref="UniProtKB/Swiss-Prot:O31576" /translation="MEKRYSQMTPHELNTEIALLSEKARKAEQHGIINELAVLERKIT MAKAYLLNPEDYSPGETYRVENTEDEFTISYLNGVFAWGYRTSSPQQEEALPISVLQE KE*" /label="yfhH CDS" gene 850654..850968 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /label="yfhH gene" S_feature complement(850876..851144) /Source="Nicolas_S_feature" /locus_tag="new_926651_926919_c" /HighExp="S8, S6, S5, S7, C30, S4, nit, ferm, BT, G135" /AntisenseName="yfhH" /AntisenseCor="-0.53569713251514905" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S289" downshifts 850958 /Source="Nicolas_upshifts" /id="D424" /incds=0 /nref=71 /ntot=206 /MaxReadThrough="2.93348" /MaxDrop="5.2859" /score="24.7235138" /energy="-11.6" /TU="NA" /idTUdmin="U648" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 851042..851047 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 851063..851082 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 851068 /Source="Nicolas_upshifts" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="upshifts" CDS 851111..852304 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388735.1" /db_xref="EnsemblGenomes-Gn:BSU08540" /db_xref="EnsemblGenomes-Tr:CAB12683" /db_xref="GOA:O31577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12884" /db_xref="UniProtKB/Swiss-Prot:O31577" /translation="MSIKNPSVKFIIFVLMICTFSIGYTEYAVMGILTSIANDFHIQV SSAGLLVTAYAASVCLTGPLVTIISVKLPRKPVLLGLMAIFILSNLMSALAPNFAVLA ISRILSASIHGAFFAIAMVFASEMVPPEKRAAAAASMNGGLTVALMLGVPFGSYLGDV LNWRAVFSIITALGVIGFLGLMAAVPNRKPKVIPMLMNEWGVFKHKQVLFSFAITILG YSGVFIAYTFIEPILRHSAGFSTVGITGALFAYGLGGVAGNFFAGKVPLPLLTRTMIG VMIGLIGVLAVFPYIAIYPAAAIVATFLFGACAFGTPPLLQTKVISSSEGGTTIAAAV SVSAFNLANALGAWIGGMILNGTGSYSWLFAGGALMTACGLVLSTFAHLSEKKSVYEY QVNKG*" /label="yfhI CDS" gene 851111..852304 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /label="yfhI gene" S_feature 852305..852539 /Source="Nicolas_S_feature" /locus_tag="new_928080_928314" /HighExp="G180, Paraq, C30, Oxctl, H2O2, G135, G150, S8, Heat, LBGstat" /AntisenseName="sspK" /AntisenseCor="1.9886505145521101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S290" CDS complement(852337..852489) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054573.1" /db_xref="EnsemblGenomes-Gn:BSU08550" /db_xref="EnsemblGenomes-Tr:CAE01449" /db_xref="GOA:Q7WY75" /db_xref="InterPro:IPR012611" /db_xref="SubtiList:BG14175" /db_xref="UniProtKB/Swiss-Prot:Q7WY75" /translation="MVRNKEKGFPYENENKFQGEPRAKDDYASKRADGSINQHPQERM RASGKR*" /label="sspK CDS" gene complement(852337..852489) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /label="sspK gene" downshifts complement(852354) /Source="Nicolas_upshifts" /id="D425" /incds=0 /nref=24 /ntot=45 /MaxReadThrough="2.36419" /MaxDrop="4.9889" /score="20.2715496" /energy="-12.3" /TU="NA" /idTUdmin="U652" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 852518..852525 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 852539..852558 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 852541..852613 /Source="Nicolas_S_feature" /locus_tag="new_928316_928388" /HighExp="dia5, LPhT, Diami, dia15, Etha, T0.30H, H2O2, LBGstat, BC, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S291" upshifts 852541 /Source="Nicolas_upshifts" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(852548..852559) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(852558) /Source="Nicolas_upshifts" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(852574..852580) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 852614..852883 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388736.1" /db_xref="EnsemblGenomes-Gn:BSU08560" /db_xref="EnsemblGenomes-Tr:CAB12684" /db_xref="InterPro:IPR026952" /db_xref="SubtiList:BG12885" /db_xref="UniProtKB/Swiss-Prot:O31578" /translation="MNMYIEKLTNLLLEKNEMISYIQAKTWVELLWSDFEATYAKAGH AYQGEKMTEKIVTQWIENYGGQLHLFQSSRNDVNDYLNQSRGLLH*" /label="yfhJ CDS" gene 852614..852883 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /label="yfhJ gene" downshifts 852872 /Source="Nicolas_upshifts" /id="D426" /incds=0 /nref=62 /ntot=233 /MaxReadThrough="2.9538" /MaxDrop="5.3621" /score="19.3423239" /energy="-10.6" /TU="NA" /idTUdmin="U650" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 852961..852967 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 852982 /Source="Nicolas_upshifts" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 852983..853001 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 853028..853546 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388737.1" /db_xref="EnsemblGenomes-Gn:BSU08570" /db_xref="EnsemblGenomes-Tr:CAB12685" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12886" /db_xref="UniProtKB/Swiss-Prot:O31579" /translation="MKKKQVMLALTAAAGLGLTALHSAPAAKAAPLHDISVSMPSSDT YIIKAGKLNVRTEPNHEGDILGTVSSEQKVKVDRFVNADWAQIHFKGKKAYISTHFLM KTASQAKTTKQTAFYTPTPENGKAKQLSSGTEVTILGWGFSENGGFDFTWAFVDYGGV KGYIHTKDLQMR*" /label="yfhK CDS" gene 853028..853546 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /label="yfhK gene" S_feature 853547..853614 /Source="Nicolas_S_feature" /locus_tag="new_929322_929389" /HighExp="Etha, Sw, Salt, M9-stat, B60, B36, Gly, LoTm, BC, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S292" promotor_-35 853582..853591 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-35" promotor_-10 853603..853618 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-10" upshifts 853616 /Source="Nicolas_upshifts" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="upshifts" CDS 853631..853963 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor for peptide SdpC immunity" /protein_id="NP_388738.1" /db_xref="EnsemblGenomes-Gn:BSU08580" /db_xref="EnsemblGenomes-Tr:CAB12686" /db_xref="GOA:O31580" /db_xref="InterPro:IPR025962" /db_xref="SubtiList:BG12887" /db_xref="UniProtKB/Swiss-Prot:O31580" /translation="MTGLVGGGLMIIAGILIKLFPPKSINSVYGYRTRRSMSDQRLWN EANRYSASLMILSGLVIAGMGLLLGSNLFILQLILLIAACVITFMLTEKRLKIMTHSQ GGDRSGRS*" /label="spdL CDS" gene 853631..853963 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /label="spdL gene" CDS 853950..854810 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /EC_number="3.3.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16597997, 20941576" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16597997, 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stress induced epoxide hydrolase" /protein_id="NP_388739.1" /db_xref="EnsemblGenomes-Gn:BSU08590" /db_xref="EnsemblGenomes-Tr:CAB12687" /db_xref="GOA:O31581" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12888" /db_xref="UniProtKB/Swiss-Prot:O31581" /translation="MDGVKCQFVNTNGITLHVAAAGREDGPLIVLLHGFPEFWYGWKN QIKPLVDAGYRVIAPDQRGYNLSDKPEGIDSYRIDTLRDDIIGLITQFTDEKAIVIGH DWGGAVAWHLASTRPEYLEKLIAINIPHPHVMKTVTPLYPPQWLKSSYIAYFQLPDIP EASLRENDYDTLDKAIGLSDRPALFTSEDVSRYKEAWKQPGALTAMLNWYRALRKGSL AEKPSYETVPYRMIWGMEDRFLSRKLAKETERHCPNGHLIFVDEASHWINHEKPAIVN QLILEYLKNQ*" /label="ephM CDS" gene 853950..854810 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /label="ephM gene" downshifts 854808 /Source="Nicolas_upshifts" /id="D427" /incds=0 /nref=27 /ntot=191 /MaxReadThrough="5.0793" /MaxDrop="4.1326" /score="3.7712168" /energy="-8.4" /TU="U653,U654" /idTUdmin="U654" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-35 854868..854874 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 854888..854899 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 854896..854960 /Source="Nicolas_S_feature" /locus_tag="new_930671_930735" /HighExp="Etha, S5, M9-stat, T0.30H, Sw, T-0.40H, B60, S8, B36, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S293" upshifts 854896 /Source="Nicolas_upshifts" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(854918..854937) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(854927) /Source="Nicolas_upshifts" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 854943..854949 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(854951..854952) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 854962..855042 /Source="Nicolas_S_feature" /locus_tag="new_930737_930817" /HighExp="M9-stat, LBGexp, Lbexp, T0.30H, dia0, T1.30H, T1.0H, LBGtran, Paraq, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF, SigB" /TUshortPSig="1, 0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S294" upshifts 854962 /Source="Nicolas_upshifts" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 854964..854982 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 855043..856032 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /EC_number="2.4.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8921856, 9636707, 23632331; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bactoprenol glycosyl transferase, phageorigin" /protein_id="NP_388740.1" /db_xref="EnsemblGenomes-Gn:BSU08600" /db_xref="EnsemblGenomes-Tr:CAB12688" /db_xref="GOA:Q45539" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11834" /db_xref="UniProtKB/Swiss-Prot:Q45539" /translation="MKQGLISIIIPSYNEGYNVKLIHESLKKEFKNIHYDYEIFFIND GSVDDTLQQIKDLAATCSRVKYISFSRNFGKEAAILAGFEHVQGEAVIVMDADLQHPT YLLKEFIKGYEEGYDQVIAQRNRKGDSFVRSLLSSMYYKFINKAVEVDLRDGVGDFRL LSRQAVNALLKLSEGNRFSKGLFCWIGFDQKIVFYENVERKNGTSKWSFSSLFNYGMD GVVSFNHKPLRLCFYTGIFILLLSIIYIIATFVKILTNGISVPGYFTIISAVLFLGGV QLLSLGIIGEYIGRIYYETKKRPHYLIKEANIPNKDLPETNELKSMRRLTKMH*" /label="csbB CDS" gene 855043..856032 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /label="csbB gene" upshifts complement(855192) /Source="Nicolas_upshifts" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(855197..855201) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(855218..855222) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 856033..856103 /Source="Nicolas_S_feature" /locus_tag="new_931808_931878" /HighExp="LPhT, Heat, Etha, LBGexp, M9-stat, LBGtran, Lbexp, Sw, dia0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigB" /TUshortPSig="1, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S295" CDS 856104..858689 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23632331; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388741.2" /db_xref="EnsemblGenomes-Gn:BSU08610" /db_xref="EnsemblGenomes-Tr:CAB12689" /db_xref="GOA:O31582" /db_xref="InterPro:IPR018580" /db_xref="SubtiList:BG12889" /db_xref="UniProtKB/Swiss-Prot:O31582" /translation="MKRKHIMIYAASLLVSVLAHAFFVKEWAEGRYMTGPGDGLAQMI VFKKLLFDQYTHGNFFYNYSFGLGGGTFSQLGYYFSASFLFLAVSAAVWLLQAVQLIG ETDTLFWAESAVFISIFKLSLIIFTSASVFHYLLKHRAASFTGAVLYGVSIIYFRHEA YWEFFTDTMVWLPLLVLGAEKIIRERRPAWFIVACSLTLINNFYFAYINLIFIGIYVL FRWLIRLEPHEEKRWIQIRLFLVSGFISFGISAAAFVPVVYGFLNNLRPPYSQKIEWL NFDDNILFSSRIIIVPAAFLLFLFIISFYKNRVFRLFAGLSLLFILFHFSPYAASVFN GFSAPQNRFEYVLAFTIAGAAAAGLSQLSELKRKELLPAAAVVLLLYLYHIQRYKLDI WKPANESILLLLLMTIAALFAAAFAKKRAKMAVYGIIILSSLFVANSYQKYALSEGGD LDSVTKEYLTSEEYRGRESSELIRRLQKEDDDPLMRIDWMNGVRNNTPIIYGFNGFSA YSSILNKDLLAFYWNDLSIDMGRESVSRYASLGDRANLYSLLYGKYYMTEKTNEASVP YGFKKHLETEHYAVYENQYMLPFVKTADAIYSESELDRLPALAKEQAMLKGIILKDPS GKTEQTPKPSNLITKSDITAKQAQYQNGLLTVTGENGGELIITPKQPSSAPGDYYVSF YLKSKAKDKGFTLKVNDYVTTRKSNKSIYKTGVNNITVRVPKSGHISINLPKGTYELR NIALYEENYQTLKNAVMQNKTEKADKLNWNKNRLTFSYHLSKDQYIMLPIPYEKGWEL KINGKTQKIEKADYAFIGFKAQKGDNHIELTYYPPYFKISAIISLVSLLLAVFYIRRK KPGSI*" /label="yfhO CDS" gene 856104..858689 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /label="yfhO gene" downshifts 858658 /Source="Nicolas_upshifts" /id="D428" /incds=0 /nref=63 /ntot=217 /MaxReadThrough="2.13267" /MaxDrop="4.17784" /score="2.41489488" /energy="-13.3" /TU="NA" /idTUdmin="U657" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(858682..859665) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10463184, 10524235, 15849754, 16850406, 24237659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_388742.1" /db_xref="EnsemblGenomes-Gn:BSU08620" /db_xref="EnsemblGenomes-Tr:CAB12690" /db_xref="GOA:O31583" /db_xref="InterPro:IPR007404" /db_xref="SubtiList:BG12890" /db_xref="UniProtKB/Swiss-Prot:O31583" /translation="MDTGTHVVMGIALGGIATLDPVVGSDPAMAHAVMIATLAGSQAP DIDTVLKLKNNAVYIRNHRGFTHSIPAVLFWSVIIPAILYLFYPQADFLHLWLWTLLA VVLHVFVDIFNAYGTQAIRPFSKKWVALGLINTFDPFIFISHLAAIAIWYAGGSPGIT FLSLYIILVGYYLVRLIMQLRIKRKLHEMIHDEIESIIISPTMKFRQWRIAVTTAHAF YVGRSMEGHVVILDTFNRVPVPETDVMHAAKQDDNIAAFLSFSPVYRWEVDTFKDHYE VRFIDLRYRSKGHYPFVAIVHIGHDLTIRSSYTGWIFSEEKLQKKLKLGSI*" /label="yfhP CDS" gene complement(858682..859665) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /label="yfhP gene" downshifts complement(858716) /Source="Nicolas_upshifts" /id="D429" /incds=0 /nref=28 /ntot=200 /MaxReadThrough="2.65266" /MaxDrop="4.43244" /score="25.5564412" /energy="-17.5" /TU="NA" /idTUdmin="U661" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 859139..859148 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 859161..859180 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 859165 /Source="Nicolas_upshifts" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(859666..859813) /Source="Nicolas_S_feature" /locus_tag="new_935441_935588_c" /HighExp="Diami, dia15, M9-stat, dia5, Etha, H2O2, S6, Salt, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S296" promotor_-35 859770..859774 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 859790..859809 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 859797 /Source="Nicolas_upshifts" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="upshifts" S_feature 859803..859880 /Source="Nicolas_S_feature" /locus_tag="new_935578_935655" /HighExp="H2O2, G150, G180, LBGstat, dia15, Diami, Oxctl, Paraq, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S297" promotor_-10 complement(859811..859830) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(859813) /Source="Nicolas_upshifts" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(859845..859852) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 859881..860990 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /EC_number="3.2.2.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10463184, 20971907, 21954439, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10463184, 20971907, 21954439, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="A/G-specific adenine glycosylase or DNA-(apurinic or apyrimidinic site) lyase" /protein_id="NP_388743.1" /db_xref="EnsemblGenomes-Gn:BSU08630" /db_xref="EnsemblGenomes-Tr:CAB12691" /db_xref="GOA:O31584" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR005760" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR029119" /db_xref="SubtiList:BG12891" /db_xref="UniProtKB/Swiss-Prot:O31584" /translation="MNVLEDKLKQKDIQQFRDDLISWFEREQRVLPWREDQDPYKVWV SEVMLQQTRVETVIPYFLRFVEQFPTVEALADADEEKVLKAWEGLGYYSRVRNLQSAV KEVKQEYGGIVPPDEKDFGGLKGVGPYTKGAVLSIAYNKPIPAVDGNVMRVMSRILSI WDDIAKPKTRTIFEDAIRAFISKEKPSEFNQGLMELGALICTPKSPSCLLCPVQQHCS AFEEGTERELPVKSKKKKPGIKTMAAIVLTDEDGQVYIHKRPSKGLLANLWEFPNLET QKGIKTEREQLIAFLENEYGIQADISDLQGVVEHVFTHLVWNISVFFGKVKQVSDTSK LKKVTKEELEQFAFPVSHQKIWKMAGEAAAISAAP*" /label="mutY CDS" gene 859881..860990 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /label="mutY gene" promotor_-35 860827..860831 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 860847..860866 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 860859 /Source="Nicolas_upshifts" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="upshifts" S_feature 860991..861303 /Source="Nicolas_S_feature" /locus_tag="new_936766_937078" /HighExp="H2O2, G150, dia15, G135, G180, Oxctl, Paraq, dia0, LBGexp, Lbexp" /AntisenseName="yfhS" /AntisenseCor="-0.72611377663365595" /AntisenseRegPval="-44.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S298" CDS complement(860998..861222) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10463184" /codon_start=1 /transl_table=11 /product="conserved protein related to sporulation" /protein_id="NP_388744.1" /db_xref="EnsemblGenomes-Gn:BSU08640" /db_xref="EnsemblGenomes-Tr:CAB12692" /db_xref="SubtiList:BG12892" /db_xref="UniProtKB/Swiss-Prot:O31585" /translation="MYVGRDMSELNMVSKKDWKNSELAYFHHAFQQIMPYLNEEGQSK YRELTQEIEARGGMKRNEADYSHGTRVSYD*" /label="yfhS CDS" gene complement(860998..861222) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /label="yfhS gene" promotor_-10 complement(861252..861263) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(861254) /Source="Nicolas_upshifts" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(861277..861283) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 861304..862056 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /EC_number="1.3.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 12440970, 17329825, 21185310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 12440970, 17329825, 21185310; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase III" /protein_id="NP_388745.1" /db_xref="EnsemblGenomes-Gn:BSU08650" /db_xref="EnsemblGenomes-Tr:CAB12693" /db_xref="GOA:P71079" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIC" /db_xref="PDB:3OID" /db_xref="SubtiList:BG12221" /db_xref="UniProtKB/Swiss-Prot:P71079" /translation="MEQNKCALVTGSSRGVGKAAAIRLAENGYNIVINYARSKKAALE TAEEIEKLGVKVLVVKANVGQPAKIKEMFQQIDETFGRLDVFVNNAASGVLRPVMELE ETHWDWTMNINAKALLFCAQEAAKLMEKNGGGHIVSISSLGSIRYLENYTTVGVSKAA LEALTRYLAVELSPKQIIVNAVSGGAIDTDALKHFPNREDLLEDARQNTPAGRMVEIK DMVDTVEFLVSSKADMIRGQTIIVDGGRSLLV*" /label="fabL CDS" gene 861304..862056 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /label="fabL gene" promotor_-35 862073..862079 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 862094..862105 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 862095 /Source="Nicolas_upshifts" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(862102..862116) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(862123) /Source="Nicolas_upshifts" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(862125..862129) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 862125..862379 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1744043, 7592342, 9540829, 19542328, 23314362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744043, 7592342, 9540829, 19542328, 23314362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (gamma-type SASP)" /protein_id="NP_388746.1" /db_xref="EnsemblGenomes-Gn:BSU08660" /db_xref="EnsemblGenomes-Tr:CAB12694" /db_xref="GOA:P07784" /db_xref="InterPro:IPR006341" /db_xref="SubtiList:BG10789" /db_xref="UniProtKB/Swiss-Prot:P07784" /translation="MANSNNFSKTNAQQVRKQNQQSAAGQGQFGTEFASETNAQQVRK QNQQSAGQQGQFGTEFASETDAQQVRQQNQSAEQNKQQNS*" /label="sspE CDS" gene 862125..862379 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /label="sspE gene" downshifts 862377 /Source="Nicolas_upshifts" /id="D430" /incds=0 /nref=261 /ntot=269 /MaxReadThrough="1.59207" /MaxDrop="8.74804" /score="9.25353719" /energy="-9.5" /TU="NA" /idTUdmin="U660" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(862402) /Source="Nicolas_upshifts" /id="D431" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.21036" /MaxDrop="5.14076" /score="-9.78320441" /energy="-7.1" /TU="NA" /idTUdmin="U663" /TUdmin="-1687" /isTUend="FALSE" /label="downshifts" CDS 862468..862812 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388747.1" /db_xref="EnsemblGenomes-Gn:BSU08670" /db_xref="EnsemblGenomes-Tr:CAB12695" /db_xref="InterPro:IPR025572" /db_xref="SubtiList:BG12222" /db_xref="UniProtKB/Swiss-Prot:P71080" /translation="MSQRVCFMEIEMIKGGNVYTFIRLKEEPMTEFEKLVSEQMKTMD KLLDLQSELDRCKQIEAELRHLERDARLRGIQAEIAVKRKHLADIQDMFQKQTEQVIR SYRSSEKPSSFV*" /label="ygaB CDS" gene 862468..862812 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /label="ygaB gene" promotor_-35 862475..862483 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 862494..862512 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 862496 /Source="Nicolas_upshifts" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="upshifts" downshifts 862795 /Source="Nicolas_upshifts" /id="D432" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.84572" /MaxDrop="3.29993" /score="13.9694142" /energy="-11.5" /TU="U666" /idTUdmin="U660" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-35 862851..862858 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 862872..862891 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 862881..862955 /Source="Nicolas_S_feature" /locus_tag="new_938656_938730" /HighExp="Etha, dia15, dia5, Diami, Salt, H2O2, BC, T5.0H, Cold, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S299" upshifts 862881 /Source="Nicolas_upshifts" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="upshifts" CDS 862956..863486 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19383706, 22333191; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding factor" /protein_id="NP_388748.3" /db_xref="EnsemblGenomes-Gn:BSU08680" /db_xref="EnsemblGenomes-Tr:CAB12696" /db_xref="InterPro:IPR007295" /db_xref="InterPro:IPR016882" /db_xref="InterPro:IPR035930" /db_xref="SubtiList:BG12223" /db_xref="UniProtKB/Swiss-Prot:Q796Z1" /translation="MGYPKEGETIQIHSYKHNGLIHRIWNETTILKSTEMCVIGANDR TMVTESDGRTWITREPAICYFHARQWFNVIGMLREDGVHYYCNISSPFAYDGEAIKYI DYDLDVKVFPDMTYNILDEDEYDDHRKAMNYPKEIDSILRDYLNTLLHWIHQRQGPFA PEFVDMWYERYLRYTK*" /label="ygaC CDS" gene 862956..863486 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /label="ygaC gene" downshifts 863477 /Source="Nicolas_upshifts" /id="D433" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="6.10669" /MaxDrop="3.97335" /score="-5.22328881" /energy="-7" /TU="U667" /idTUdmin="U666" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 863574..865316 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388749.2" /db_xref="EnsemblGenomes-Gn:BSU08690" /db_xref="EnsemblGenomes-Tr:CAB12697" /db_xref="GOA:P71082" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12224" /db_xref="UniProtKB/Swiss-Prot:P71082" /translation="MGVMKRYMQFVKPYKKQIFVTVLIGIVKFSIPLALPLLLKYVVD DIIQGGGTASDKTTSLFTIMAIMFALFLILRPPVEYYRQYFAQWTASKVLYDIRAKLF DHIQKLSLRFYANTRTGEVISRVINDVEQTKDFVITGLMNIWLDMLTILIVISIMLTL DVKLTLISIVLFPLYGISVKYFYGRLRKLTRERSQALAQVQGHLHERIQGMPVIRSFA IEDHEQAQFNEKNGHFLDKAIRHTNWNAKTFAVVNTITDLAPLIVIACAGYFVINGPL TVGTMVAFVGYIDRMYNPVRRLINSSTTLTQSIASMDRVFEFIDEPYELTDKPNAIKA DQIRGGVEFQNVSFQYEKDKENILHDVSLKVNRGETVALVGMSGGGKSTLVSLIPRFY DVTSGRLLIDGTDIRDYEARSLRNQVGMVLQDTFLFSETIRENIAIGKPDATLEEIIE AAKAANAHEFIMSFPEGYETRVGERGVKLSGGQKQRISIARVFLKNPPLLILDEATSA LDLESEHYIQEAMDKLAKDRTTFVVAHRLSTITHADKIVVMENGTIIEIGTHDELMDY ESQYKHLFTIQNLN*" /label="ygaD CDS" gene 863574..865316 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /label="ygaD gene" downshifts 865303 /Source="Nicolas_upshifts" /id="D434" /incds=0 /nref=87 /ntot=233 /MaxReadThrough="2.54676" /MaxDrop="5.20475" /score="22.3853226" /energy="-14.1" /TU="NA" /idTUdmin="U667" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(865393..866454) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388750.1" /db_xref="EnsemblGenomes-Gn:BSU08700" /db_xref="EnsemblGenomes-Tr:CAB12698" /db_xref="GOA:P71083" /db_xref="InterPro:IPR010343" /db_xref="SubtiList:BG12225" /db_xref="UniProtKB/Swiss-Prot:P71083" /translation="MKLGARIFKTGIAITLALYLASWIGLPAPIFAGIAAIFAIQPSI YRSFLIIIDQVQANIIGAVIATVFGLIFGPSPIMIGLTAVIVITIMLKLKIEHTISIA LVTVIAILESAGDDFLMFALIRTSTVILGVLSSFIVNLVFLPPKYETKLIHNTVENTE EIMKWIRLSMRQSTEHSILKEDIEKLKEKMIKLDQTYLLYKEERSYFKKTTYVKSRKL VLFRQAIITANRALDTLKKLHRLENEIYHMPEEFQETLTEELDYLLYWHERILMRFVG KIKPHDDAVEEGIRYKQLLTKSFLKNQQNTDEELIDYNMLNIMASAVEYREQLEHLET LITSFQTYHPKDCEIETEE*" /label="ygaE CDS" gene complement(865393..866454) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /label="ygaE gene" downshifts complement(865404) /Source="Nicolas_upshifts" /id="D435" /incds=0 /nref=181 /ntot=254 /MaxReadThrough="1.1413" /MaxDrop="7.13599" /score="26.0617552" /energy="-9.4" /TU="NA" /idTUdmin="U668" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" S_feature complement(866455..866545) /Source="Nicolas_S_feature" /locus_tag="new_942230_942320_c" /HighExp="G180, Oxctl, Paraq, C30, G150, LBGexp, LPhT, S4, G135, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S300" promotor_-10 complement(866543..866562) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(866552) /Source="Nicolas_upshifts" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(866577..866584) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(866674..867963) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231799, 19930658; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde aminotransferase, classIII aminotransferase" /protein_id="NP_388751.3" /db_xref="EnsemblGenomes-Gn:BSU08710" /db_xref="EnsemblGenomes-Tr:CAB12699" /db_xref="GOA:P71084" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11943" /db_xref="UniProtKB/Swiss-Prot:P71084" /translation="MHTKSIELHNEALQHIVGGVNSPSRSYKAVGGGSPVAMEKASGA YFWDVDGNKYIDYLAAYGPIITGHAHPHITEAIKKAAENGVLYGTPTKHEVTFAKMLK EAIPAMDKVRFVNSGTEAVMTTIRVARAYTGRTKIIKFAGCYHGHSDLVLVAAGSGPS TLGTPDSAGVPKSIANEVITVPFNDIDSYKAALEKWGSEIAAVLVEPIVGNFGIVEPK EGFLEQVNELTHNAGALVIYDEVITAFRFMYGGAQDLLQVKPDLTALGKIIGGGLPIG AYGGKQEIMEQVAPLGPAYQAGTMAGNPASILSGIACLEVLKEKGVYEKLDHLGAMLE EGILKHAETHGITITVNRLKGALTVYFSDEKVENYEQAERSDGETFSTFFKLMLERGI NLAPSKYEAWFITTAHTEQDIKDTLTAVEDAFKHLKN*" /label="gsaB CDS" gene complement(866674..867963) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /label="gsaB gene" downshifts complement(866677) /Source="Nicolas_upshifts" /id="D436" /incds=0 /nref=235 /ntot=258 /MaxReadThrough="2.54961" /MaxDrop="5.8522" /score="29.5551149" /energy="-11" /TU="NA" /idTUdmin="U669" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(867991..868010) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(868010) /Source="Nicolas_upshifts" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(868012..868723) /Source="Nicolas_S_feature" /locus_tag="new_943787_944498_c" /HighExp="LoTm, M9-stat, B60, S8, C30, Cold, B36, T1.30H, Etha, T2.0H" /AntisenseName="ygaF" /AntisenseCor="-0.29702219161000198" /AntisenseRegPval="-6.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S301" promotor_-35 complement(868022..868027) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 868056..868063 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 868077..868096 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 868077 /Source="Nicolas_upshifts" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="upshifts" CDS 868116..868589 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /EC_number="1.11.1.15" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10644761, 11349039, 12950915, 21910476, 26723255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin with versatile activity" /protein_id="YP_054574.1" /db_xref="EnsemblGenomes-Gn:BSU08720" /db_xref="EnsemblGenomes-Tr:CAB12700" /db_xref="GOA:Q796Y8" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12226" /db_xref="UniProtKB/Swiss-Prot:Q796Y8" /translation="MTIEIGQKAPDLELKGDHGETVKLSDYKGKYIVLYFYPKDMTPG CTTEACDFRDSHESFAELDAVIIGVSPDSQEKHGKFKEKHNLPFLLLVDDEHKLAEAF DVWKLKKNFGKEYMGIERSTFLIDKEGRLIKEWRKVKVKDHVAEALQTLKDMSEK*" /label="bcp CDS" gene 868116..868589 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /label="bcp gene" promotor_-35 868626..868633 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 868648..868667 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 868654 /Source="Nicolas_upshifts" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="upshifts" CDS 868712..869149 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1580225, 16541078, 16925555, 22194458, 27935957, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1580225, 16541078, 16925555, 22194458, 27935957, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Fur family)" /protein_id="NP_388753.1" /db_xref="EnsemblGenomes-Gn:BSU08730" /db_xref="EnsemblGenomes-Tr:CAB12701" /db_xref="GOA:P71086" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FE3" /db_xref="PDB:2RGV" /db_xref="PDB:3F8N" /db_xref="SubtiList:BG12227" /db_xref="UniProtKB/Swiss-Prot:P71086" /translation="MAAHELKEALETLKETGVRITPQRHAILEYLVNSMAHPTADDIY KALEGKFPNMSVATVYNNLRVFRESGLVKELTYGDASSRFDFVTSDHYHAICENCGKI VDFHYPGLDEVEQLAAHVTGFKVSHHRLEIYGVCQECSKKENH*" /label="perR CDS" gene 868712..869149 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /label="perR gene" downshifts 869131 /Source="Nicolas_upshifts" /id="D437" /incds=0 /nref=149 /ntot=247 /MaxReadThrough="3.98479" /MaxDrop="7.52234" /score="1.62878623" /energy="-12.3" /TU="U670,U671" /idTUdmin="U670" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(869184..869537) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_054575.1" /db_xref="EnsemblGenomes-Gn:BSU08740" /db_xref="EnsemblGenomes-Tr:CAE01450" /db_xref="GOA:Q7WY74" /db_xref="InterPro:IPR020912" /db_xref="SubtiList:BG14192" /db_xref="UniProtKB/Swiss-Prot:Q7WY74" /translation="MAKYSSKINKIRTFALSLVFVGFIIMYIGIFFKESVLLSSLFMI LGLLSIGLSTVVYFWIGMLSTKAVRVICPGCDKETKVLGVVDMCMHCREPLTLDKGLE GKEFDESYNKKKMSK*" /label="ygzB CDS" gene complement(869184..869537) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /label="ygzB gene" downshifts 869197 /Source="Nicolas_upshifts" /id="D438" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="2.62283" /MaxDrop="4.13562" /score="-4.23596421" /energy="-12.5" /TU="NA" /idTUdmin="U670" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(869207) /Source="Nicolas_upshifts" /id="D439" /incds=0 /nref=182 /ntot=253 /MaxReadThrough="4.02571" /MaxDrop="6.23378" /score="9.51667757" /energy="-14.2" /TU="NA" /idTUdmin="U673" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 869533..869537 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-35" promotor_-10 869545..869559 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-10" misc_feature complement(869549..869568) /Source="Nicolas_upshift_promotors" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 869549..869640 /Source="Nicolas_S_feature" /locus_tag="new_945324_945415" /HighExp="Cold, C30, H2O2, Etha, dia15, G135, Paraq, C90, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S302" upshifts 869549 /Source="Nicolas_upshifts" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="upshifts" upshifts complement(869559) /Source="Nicolas_upshifts" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 869617..869620 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-35" promotor_-10 869635..869654 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-10" S_feature 869642..869744 /Source="Nicolas_S_feature" /locus_tag="new_945417_945519" /HighExp="BMM, Cold, LBGstat, C30, Oxctl, LBGexp, Paraq, G180, Lbexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.996, 0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S303" upshifts 869642 /Source="Nicolas_upshifts" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="upshifts" CDS 869745..870629 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388755.1" /db_xref="EnsemblGenomes-Gn:BSU08750" /db_xref="EnsemblGenomes-Tr:CAB12703" /db_xref="InterPro:IPR029348" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10951" /db_xref="UniProtKB/Swiss-Prot:Q04385" /translation="MENLLRPIYQERASHPNTLAVIMIERRNKTSSLTDNFDAALLVI VKDADEPVFIKHYEFDHQTASLHVVTDSQIQEWILLGTNRRIIDWIVNGRVLFDRNEY VVELIDRLNTFPFAERKLKIGLEYGKLIRRYVEGKAFFEANQFLDAYNAVVHALHHLA RIEVIDRGFHPETTVWSQVRQMEPQVYKLYSELIESHESLEKRLELLFLANDFLIHSK AEIGSAHLFEVMKEKDIWQFGELLQHHDLKHFTQDLGVMLDYLTEKGLINVCQIETKG QAVYHRGYSFKKGVDSDS*" /label="ygxA CDS" gene 869745..870629 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /label="ygxA gene" promotor_-35 870612..870619 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 870633..870652 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 870648..870920 /Source="Nicolas_S_feature" /locus_tag="new_946423_946695" /HighExp="LBGstat, Oxctl, C30, Paraq, GM 120, H2O2, HPh, G150, LPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.106881" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="Sig-" /TUlongPSig="0.0739" /label="S304" upshifts 870648 /Source="Nicolas_upshifts" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(870681) /Source="Nicolas_upshifts" /id="D440" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="2.70619" /MaxDrop="3.85046" /score="4.43428373" /energy="-7.8" /TU="NA" /idTUdmin="U673" /TUdmin="-1474" /isTUend="FALSE" /label="downshifts" rRNA 870921..872475 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-16S rRNA" gene 870921..872475 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /label="rrnD-16S gene" rRNA 872643..875570 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-23S rRNA" gene 872643..875570 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /label="rrnD-23S gene" S_feature 875571..875656 /Source="Nicolas_S_feature" /locus_tag="new_951346_951431" /HighExp="G135, C30, Oxctl, Paraq, LBGstat, dia0, HiTm, Fru, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S305" promotor_-35 875632..875639 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 875653..875672 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 875658 /Source="Nicolas_upshifts" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="upshifts" rRNA 875682..875797 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-5S rRNA" gene 875682..875797 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /label="rrnD-5S gene" tRNA 875807..875881 /gene="asnTA" /locus_tag="BSU_tRNA_29" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="asparagine transfer RNA (GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="asnTA tRNA" gene 875807..875881 /gene="asnTA" /locus_tag="BSU_tRNA_29" /label="asnTA gene" tRNA 875887..875978 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Ser tRNA" gene 875887..875978 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /label="trnD-Ser gene" downshifts 875974 /Source="Nicolas_upshifts" /id="D441" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="7.64297" /MaxDrop="4.37505" /score="-9.7424199" /energy="-11" /TU="U676" /idTUdmin="U677" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" tRNA 876013..876084 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Glu tRNA" gene 876013..876084 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /label="trnD-Glu gene" tRNA 876094..876169 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Val tRNA" gene 876094..876169 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /label="trnD-Val gene" tRNA 876179..876255 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Met tRNA" gene 876179..876255 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /label="trnD-Met gene" tRNA 876267..876343 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Asp tRNA" gene 876267..876343 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /label="trnD-Asp gene" tRNA 876356..876431 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Phe(GAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Phe tRNA" gene 876356..876431 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /label="trnD-Phe gene" tRNA 876437..876509 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Thr tRNA" gene 876437..876509 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /label="trnD-Thr gene" tRNA 876532..876616 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GUA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Tyr tRNA" gene 876532..876616 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /label="trnD-Tyr gene" tRNA 876622..876695 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /product="tRNA-Trp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Trp(CCA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Trp tRNA" gene 876622..876695 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /label="trnD-Trp gene" tRNA 876720..876795 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="transfer RNA-His(GUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-His tRNA" gene 876720..876795 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /label="trnD-His gene" tRNA 876805..876876 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Gln tRNA" gene 876805..876876 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /label="trnD-Gln gene" tRNA 876926..877000 /gene="glyTB" /locus_tag="BSU_tRNA_41" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="glycine transfer RNA (GCC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="glyTB tRNA" gene 876926..877000 /gene="glyTB" /locus_tag="BSU_tRNA_41" /label="glyTB gene" tRNA 877006..877076 /gene="cysTA" /locus_tag="BSU_tRNA_42" /product="tRNA-Cys" /inference="profile:tRNAscan:1.23" /note="cysteine tRNA (GCA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="cysTA tRNA" gene 877006..877076 /gene="cysTA" /locus_tag="BSU_tRNA_42" /label="cysTA gene" tRNA 877084..877172 /gene="leuTA" /locus_tag="BSU_tRNA_43" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine RNA (UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="leuTA tRNA" gene 877084..877172 /gene="leuTA" /locus_tag="BSU_tRNA_43" /label="leuTA gene" S_feature 877173..877249 /Source="Nicolas_S_feature" /locus_tag="new_952948_953024" /HighExp="Paraq, C30, Oxctl, G180, G135, Heat, BMM, LBGexp, dia15, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S306" downshifts 877206 /Source="Nicolas_upshifts" /id="D442" /incds=0 /nref=18 /ntot=231 /MaxReadThrough="5.36857" /MaxDrop="5.05259" /score="16.6649124" /energy="-8.9" /TU="U676" /idTUdmin="U677" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" S_feature 877251..877419 /Source="Nicolas_S_feature" /locus_tag="new_953026_953194" /HighExp="Heat, Paraq, BMM, Oxctl, H2O2, Cold, G180, Pyr, C30, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S307" promotor_-35 877376..877383 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 877382 /Source="Nicolas_upshifts" /id="D443" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.84674" /MaxDrop="3.439" /score="35.1424037" /energy="-12.4" /TU="U676" /idTUdmin="U677" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 877397..877416 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 877421 /Source="Nicolas_upshifts" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="upshifts" tRNA 877438..877519 /gene="leuTB" /locus_tag="BSU_tRNA_44" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine tRNA(CAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="leuTB tRNA" gene 877438..877519 /gene="leuTB" /locus_tag="BSU_tRNA_44" /label="leuTB gene" promotor_-10 complement(877455..877472) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(877458) /Source="Nicolas_upshifts" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(877493..877498) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(877528) /Source="Nicolas_upshifts" /id="D444" /incds=0 /nref=5 /ntot=151 /MaxReadThrough="1.64364" /MaxDrop="6.28675" /score="7.71223568" /energy="-12.4" /TU="NA" /idTUdmin="U679" /TUdmin=18 /isTUend="TRUE" /label="downshifts" CDS complement(877598..878374) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9795118, 22142536, 26625291, 28234965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9795118, 22142536, 26625291, 28234965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="protein involved in the control of the cell cycle as a function of the environment" /protein_id="NP_388756.2" /db_xref="EnsemblGenomes-Gn:BSU08760" /db_xref="EnsemblGenomes-Tr:CAB12704" /db_xref="GOA:P71088" /db_xref="InterPro:IPR009776" /db_xref="InterPro:IPR014756" /db_xref="PDB:5CL2" /db_xref="SubtiList:BG12229" /db_xref="UniProtKB/Swiss-Prot:P71088" /translation="MSFFKKLAASAGIGAAKVDTILEKDAYFPGEEVQGTVHVKGGKI AQDIRYIDLQLSTRYVIVKDDEEHRKYATIHSFRVTGSFTIQPGEEHQFPFTFTLPLD TPITVGKVEVAVVTDLDIQGGIDKSDHDRIFVEAHPWIENVLEAIENLGFRLNEADCE QAPYFQRRLPFVQEFEFVPTSGYYRQMLDELELIFLLDEDGLEIIFEVDRRARGLRGW LEEMYNDGEQLVRVRFSQSELEDTEELEEVLEEILDQYAE*" /label="spo0M CDS" gene complement(877598..878374) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /label="spo0M gene" downshifts complement(877612) /Source="Nicolas_upshifts" /id="D445" /incds=0 /nref=9 /ntot=131 /MaxReadThrough="6.06864" /MaxDrop="6.58787" /score="6.75662782" /energy="-7" /TU="U679" /idTUdmin="U679" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(878401..878416) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(878423) /Source="Nicolas_upshifts" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(878429..878438) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 878458..878464 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 878479..878490 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 878482 /Source="Nicolas_upshifts" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="upshifts" CDS 878516..878719 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388757.2" /db_xref="EnsemblGenomes-Gn:BSU08770" /db_xref="EnsemblGenomes-Tr:CAB12705" /db_xref="SubtiList:BG12981" /db_xref="UniProtKB/Swiss-Prot:O31586" /translation="MEVNKESLVADELHRMFLAGELQITVEEDINNISERLRNGDLSL DRLSGEDVFIKETVNEALRRVEQ*" /label="ygzA CDS" gene 878516..878719 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /label="ygzA gene" downshifts 878702 /Source="Nicolas_upshifts" /id="D446" /incds=0 /nref=22 /ntot=97 /MaxReadThrough="1.47004" /MaxDrop="5.47861" /score="15.4081475" /energy="-18.2" /TU="NA" /idTUdmin="U676" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(878778) /Source="Nicolas_upshifts" /id="D447" /incds=0 /nref=10 /ntot=35 /MaxReadThrough="1.31339" /MaxDrop="4.8918" /score="26.0684119" /energy="-18.2" /TU="NA" /idTUdmin="U681" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(878804..879076) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="YP_003097696.1" /db_xref="EnsemblGenomes-Gn:BSU08779" /db_xref="EnsemblGenomes-Tr:CAX52583" /db_xref="GOA:C0H3X8" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="UniProtKB/Swiss-Prot:C0H3X8" /translation="MYRSKKQSQILSYQELLKKQRRWFPIEQSLCPKDILDLLTTIKT SINKYTVATTATENPHIRRALHDQLDTAVYLHDELSDLLLEKGWLG*" /label="ygzC CDS" gene complement(878804..879076) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /label="ygzC gene" promotor_-10 complement(879035..879053) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(879042) /Source="Nicolas_upshifts" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 879057..879064 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-35" promotor_-35 complement(879070..879075) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 879077..879096 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-10" upshifts 879085 /Source="Nicolas_upshifts" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="upshifts" CDS 879118..879810 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase" /protein_id="NP_388758.2" /db_xref="EnsemblGenomes-Gn:BSU08780" /db_xref="EnsemblGenomes-Tr:CAB12706" /db_xref="GOA:P71089" /db_xref="InterPro:IPR005320" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12230" /db_xref="UniProtKB/Swiss-Prot:P71089" /translation="MKQIIAMGGGGFSMEPDNLSLDQYILNQSKREQPRICFLPTASG DSQNYIQRFYHAFQTLDCVPSHLSLFKPPSSDLVSFVMEMDVIYVGGGNTRNLLVLWK EWGLDHILREAWKNGVVVAGISAGAICWFEEGVTDSAGPLTSLKSLGFLQGSFCPHYD GEKDRRPAYHQLISNKFLCSGYAADDGAALHFINDQLFQTVSSRSGAKAYRVMMAEHE IAEIPLPVKYLG*" /label="ygaJ CDS" gene 879118..879810 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /label="ygaJ gene" promotor_-35 879839..879843 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(879842..879861) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(879854) /Source="Nicolas_upshifts" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 879857..879876 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(879876..879883) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA 879880..879987 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswD RNA" gene 879880..879987 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /label="tswD gene" upshifts 879887 /Source="Nicolas_upshifts" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="upshifts" downshifts 880018 /Source="Nicolas_upshifts" /id="D448" /incds=0 /nref=13 /ntot=48 /MaxReadThrough="8.09735" /MaxDrop="5.74046" /score="17.5556194" /energy="-12.4" /TU="U684" /idTUdmin="U682" /TUdmin=152 /isTUend="FALSE" /label="downshifts" CDS 880120..881892 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /EC_number="4.1.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8432721, 9370266, 10382260, 16291685, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8432721, 9370266, 10382260, 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine synthase" /protein_id="NP_388759.2" /db_xref="EnsemblGenomes-Gn:BSU08790" /db_xref="EnsemblGenomes-Tr:CAB12707" /db_xref="GOA:P45740" /db_xref="InterPro:IPR002817" /db_xref="InterPro:IPR025747" /db_xref="SubtiList:BG11246" /db_xref="UniProtKB/Swiss-Prot:P45740" /translation="MQNNSVQQANISIMSSFSGSKKVYVEGSSSDIQVPMREIALSPT TGSFGEEENAPVRVYDTSGPYTDPEVTINIQEGLKPLRQKWITERGDVEEYEGRAIKP EDNGYKKAKPNVSYPGLKRKPLRAKAGQNVTQMHYAKKGIITPEMEFIAIREHVSPEF VRDEVASGRAIIPSNINHPESEPMIIGRNFHVKINANIGNSAVTSSIEEEVEKMTWAI RWGADTMMDLSTGKDIHTTREWIIRNCPVPVGTVPIYQALEKVNGVAEDLTWEIYRDT LIEQAEQGVDYFTIHAGVLLRYVPLTAKRTTGIVSRGGAIMAQWCLAHHQESFLYTHF EEICEIMKMYDIAFSLGDGLRPGSIADANDEAQFAELETLGELTQIAWKHDVQVMIEG PGHVPMHKIKENVDKQMDICKEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWYGTAM LCYVTPKEHLGLPNRDDVREGVITYKIAAHAADLAKGHPGAQIRDDALSKARFEFRWR DQFNLSLDPERALEYHDETLPAEGAKTAHFCSMCGPKFCSMRISQDIRDYAKKNDLSE AEAINKGLKEKAKEFVDTGSNLYQ*" /label="thiC CDS" gene 880120..881892 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /label="thiC gene" downshifts 881868 /Source="Nicolas_upshifts" /id="D449" /incds=0 /nref=166 /ntot=257 /MaxReadThrough="5.77069" /MaxDrop="5.3684" /score="25.2366359" /energy="-15.3" /TU="U684" /idTUdmin="U684" /TUdmin="-946" /isTUend="FALSE" /label="downshifts" S_feature 881913..882838 /Source="Nicolas_S_feature" /locus_tag="new_957688_958613" /HighExp="HiOs, GM-0.1, GM 45, GM 60, GM-0.2, BMM, MG 90, T-5.40H, MG 15, MG 25" /AntisenseName="ygaK" /AntisenseCor="-9.7288827054566707E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="SigA" /TUlongPSig=1 /label="S308" CDS complement(881930..883285) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /EC_number="1.21.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8972604; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FAD-dependent oxido-reductase" /protein_id="NP_388760.2" /db_xref="EnsemblGenomes-Gn:BSU08800" /db_xref="EnsemblGenomes-Tr:CAB12708" /db_xref="GOA:Q796Y5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12231" /db_xref="UniProtKB/Swiss-Prot:Q796Y5" /translation="MEKTKLTGRIVTRDDPDYNEARTNINLSLERYPDIIVFCQNKQD ALNALKWARENRVPFRIRGGRHSYENFSLLNNGLVIDLSEMKKITVNQDKKLAYIEAG AELGEVYRTLWQYGLTLPAGTIANVGLTGLTLGGGIGLLTRAAGLTCDSLVQLEMIVA DEKEGADLITVSCSNHPDLFWASQGGGGGNFGIVTSMTFKAVPISQVSIFSITWGWDD FEEVYNTWQNWAPYTDDRLTSSIEFWPKEVNRIEALGQFVGPKTELKKLLKPLLKAGS PTSGMVKTTPFIEAVTFFNSPGGNQPQKMKRSGSFIEKPLSERAISTIKHFLEHAPNQ NASVWQQALGGAAGRVAPDQTAFYYRDAIIAQEYLTNWTSPGEKRQNVRWIEGLRTSL SKETMGDYVNWPDIEIRNWPRTYYGENVERLRRVKTTYDPENVFRFEQSIPPLRRSLF F*" /label="ygaK CDS" gene complement(881930..883285) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /label="ygaK gene" promotor_-10 complement(883313..883332) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(883330) /Source="Nicolas_upshifts" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(883346..883355) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 883403..883409 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 883424..883443 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 883452 /Source="Nicolas_upshifts" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="upshifts" CDS 883536..883733 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1479343, 2108127, 8323536, 16321961" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1479343, 2108127, 8323536, 16321961; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (repressor of ScoC)" /protein_id="NP_388761.2" /db_xref="EnsemblGenomes-Gn:BSU08810" /db_xref="EnsemblGenomes-Tr:CAB12709" /db_xref="GOA:P21344" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG10747" /db_xref="UniProtKB/Swiss-Prot:P21344" /translation="MGVKKEKGRKRFRKRKTYGNQILPLELLIEKNKREIINSAELME EIYMKIDEKHTQCVTKYKKTR*" /label="senS CDS" gene 883536..883733 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /label="senS gene" CDS complement(883760..885211) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /EC_number="1.11.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 12486061, 16535198, 22194458, 27935957" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12486061, 16535198, 22194458, 27935957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vegetative catalase 1" /protein_id="NP_388762.2" /db_xref="EnsemblGenomes-Gn:BSU08820" /db_xref="EnsemblGenomes-Tr:CAB12710" /db_xref="GOA:P26901" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG10849" /db_xref="UniProtKB/Swiss-Prot:P26901" /translation="MSSNKLTTSWGAPVGDNQNSMTAGSRGPTLIQDVHLLEKLAHFN RERVPERVVHAKGAGAHGYFEVTNDVTKYTKAAFLSEVGKRTPLFIRFSTVAGELGSA DTVRDPRGFAVKFYTEEGNYDIVGNNTPVFFIRDAIKFPDFIHTQKRDPKTHLKNPTA VWDFWSLSPESLHQVTILMSDRGIPATLRHMHGFGSHTFKWTNAEGEGVWIKYHFKTE QGVKNLDVNTAAKIAGENPDYHTEDLFNAIENGDYPAWKLYVQIMPLEDANTYRFDPF DVTKVWSQKDYPLIEVGRMVLDRNPENYFAEVEQATFSPGTLVPGIDVSPDKMLQGRL FAYHDAHRYRVGANHQALPINRARNKVNNYQRDGQMRFDDNGGGSVYYEPNSFGGPKE SPEDKQAAYPVQGIADSVSYDHYDHYTQAGDLYRLMSEDERTRLVENIVNAMKPVEKE EIKLRQIEHFYKADPEYGKRVAEGLGLPIKKDS*" /label="katA CDS" gene complement(883760..885211) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /label="katA gene" downshifts complement(883770) /Source="Nicolas_upshifts" /id="D450" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="1.32399" /MaxDrop="8.8938" /score="25.1548262" /energy="-8.3" /TU="NA" /idTUdmin="U688" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 885188..885194 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 885209..885228 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 885212 /Source="Nicolas_upshifts" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(885229..885248) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 885234..885563 /Source="Nicolas_S_feature" /locus_tag="new_961009_961338" /HighExp="S8, C30, S7, S6, BT, C90, B36, S4, S5, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.528" /TUlongSig="NA" /TUlongPSig="NA" /label="S309" upshifts complement(885248) /Source="Nicolas_upshifts" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(885262..885269) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(885307..885325) /Source="Nicolas_upshift_promotors" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(885332) /Source="Nicolas_upshifts" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="upshifts" downshifts 885520 /Source="Nicolas_upshifts" /id="D451" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="5.89897" /MaxDrop="4.66837" /score="39.0049465" /energy="-19.7" /TU="U687" /idTUdmin="U686" /TUdmin=1936 /isTUend="FALSE" /label="downshifts" CDS 885619..886386 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (ATP-bindingprotein)" /protein_id="NP_388763.3" /db_xref="EnsemblGenomes-Gn:BSU08830" /db_xref="EnsemblGenomes-Tr:CAB12711" /db_xref="GOA:P97027" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017875" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12232" /db_xref="UniProtKB/Swiss-Prot:P97027" /translation="MAVTISIKEKAFVQEGRKNTVLENIELSIAPGEFLTLIGPSGCG KSTLLKIIAGLDSEYDGSVEINGRSVTAPGIQQGFIFQEHRLFPWLTVEQNIAADLNL KDPKVKQKVDELIEIVRLKGSEKAYPRELSGGMSQRVAIARALLREPEVLLLDEPFGA LDAFTRKHLQDVLLDIWRKKKTTMILVTHDIDESVYLGNELAILKAKPGKIHKLMPIH LAYPRNRTTPDFQAIRQRVLSEFEKTEDLEYAEGSGI*" /label="ssuB CDS" gene 885619..886386 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /label="ssuB gene" CDS 886404..887402 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type f: factor" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (binding lipoprotein)" /protein_id="NP_388764.1" /db_xref="EnsemblGenomes-Gn:BSU08840" /db_xref="EnsemblGenomes-Tr:CAB12712" /db_xref="GOA:P40400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR010067" /db_xref="InterPro:IPR015168" /db_xref="SubtiList:BG10656" /db_xref="UniProtKB/Swiss-Prot:P40400" /translation="MKKGLIVLVAVIFLLAGCGANGASGDHKQLKEIRIGIQQSLSPL LIAKEKGWFEDAFEKEGIKVKWVEFQSGPPQFEGLAADKLDFSQVGNSPVIAGQAAGI DFKEIGLSQDGLKANGILVNQNSGIQDVKGLKGKKIAVAKGSSGFDFLYKALDQVGLS ANDVTIIQLQPDEAASAFENGSVDAWSIWEPYLSLETMKHGAKILVNGESTDLYSPGF TLVRTKFSEEHPDEVVRFLKVFNKAVVWQKEHLDEAADLYSDIKDLDKKVVENVLKNT EPLNEIISDDIVKAQQETADFQFRTKAIDKKIDVKDVVDNTFIKKALEEHSSGGDQ*" /label="ssuA CDS" gene 886404..887402 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /label="ssuA gene" CDS 887399..888229 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11390694, 15849754, 16513748, 16850406, 16885442, 9782504" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15849754, 16513748, 16850406, 16885442, 9782504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (permease)" /protein_id="NP_388765.1" /db_xref="EnsemblGenomes-Gn:BSU08850" /db_xref="EnsemblGenomes-Tr:CAB12713" /db_xref="GOA:P40401" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10657" /db_xref="UniProtKB/Swiss-Prot:P40401" /translation="MMKAEAAGSLPKTNAEAVRKKPGRKRYGWMKGLLLPAVIIAIWQ VIGGLGVVSATVLPTPVTIVLTFKELILSGELFGHLQISIYRAALGFLLGAGLGLMIG ILAGFSKRTELYLDPSLQMLRTVPHLAVTPLFILWFGFDEVSKILLIALGAFFPVYIN TFNGIRGVDAKLFEVARVLEFKWHQQISKVILPAALPNILLGIRLSLGIAWLGLVVAE LMGSSSGVGYMIMDARQFSQTNKVFAGIIIFAVVGKLTDSFVRLLERKLLKWRNSYEG *" /label="ssuC CDS" gene 887399..888229 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /label="ssuC gene" CDS 888252..889382 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /EC_number="1.14.14.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9782504, 11390694, 16513748, 16885442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMNH2-dependent aliphatic sulfonate monooxygenase" /protein_id="NP_388766.2" /db_xref="EnsemblGenomes-Gn:BSU08860" /db_xref="EnsemblGenomes-Tr:CAB12714" /db_xref="GOA:P40402" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019911" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10658" /db_xref="UniProtKB/Swiss-Prot:P40402" /translation="MEILWFIPTHGDARYLGSESDGRTADHLYFKQVAQAADRLGYTG VLLPTGRSCEDPWLTASALAGETKDLKFLVAVRPGLMQPSLAARMTSTLDRISDGRLL INVVAGGDPYELAGDGLFISHDERYEATDEFLTVWRRLLQGETVSYEGKHIKVENSNL LFPPQQEPHPPIYFGGSSQAGIEAAAKHTDVYLTWGEPPEQVKEKIERVKKQAAKEGR SVRFGIRLHVIARETEQEAWEAAERLISHLDDDTIAKAQAALSRYDSSGQQRMAVLHQ GDRTKLEISPNLWAGIGLVRGGAGTALVGDPQTIADRIAEYQALGIESFIFSGYPHLE EAYYFAELVFPLLPFENDRTRKLQNKRGEAVGNTYFVKEKNA*" /label="ssuD CDS" gene 888252..889382 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /label="ssuD gene" misc_feature 889409..889428 /Source="Nicolas_upshift_promotors" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 889415 /Source="Nicolas_upshifts" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="upshifts" CDS 889486..890022 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur-related oxidoreductase" /protein_id="NP_388767.1" /db_xref="EnsemblGenomes-Gn:BSU08870" /db_xref="EnsemblGenomes-Tr:CAB12715" /db_xref="SubtiList:BG12233" /db_xref="UniProtKB/Swiss-Prot:P97028" /translation="MLSACGHSKQMEIKAADISDLEKNRMDVAASQAFTAEAVNIGEG ISSADMYIEHYQKGKLVERFGPVRADYSEEKTDTIQFVYFENEEGEGKNKHTTIHFGI VDKQGTIAADSSVKRDDSTTQEMTQNISSPEPITFEKPALIGSSIRGTDETMHTSEHK KELIKHQDALLYYVELHH*" /label="ygaN CDS" gene 889486..890022 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /label="ygaN gene" S_feature 890023..890093 /Source="Nicolas_S_feature" /locus_tag="new_965798_965868" /HighExp="B36, BT, B60, Etha, S5, Heat, S2, BMM, S4, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25357200000000002" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S310" promotor_-35 890063..890070 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 890084..890103 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 890095 /Source="Nicolas_upshifts" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="upshifts" CDS 890134..890403 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12904577, 17163968, 19648245, 20208344, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="alternative ribosomal protein S14" /protein_id="NP_388768.1" /db_xref="EnsemblGenomes-Gn:BSU08880" /db_xref="EnsemblGenomes-Tr:CAB12716" /db_xref="GOA:O31587" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023036" /db_xref="SubtiList:BG13085" /db_xref="UniProtKB/Swiss-Prot:O31587" /translation="MAKKSKVAKELKRQQLVEQYAGIRRELKEKGDYEALSKLPRDSA PGRLHNRCMVTGRPRAYMRKFKMSRIAFRELAHKGQIPGVKKASW*" /label="rpsNB CDS" gene 890134..890403 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /label="rpsNB gene" promotor_-35 890206..890210 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 890233..890249 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 890249 /Source="Nicolas_upshifts" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 890390 /Source="Nicolas_upshifts" /id="D452" /incds=0 /nref=41 /ntot=70 /MaxReadThrough="3.14088" /MaxDrop="6.23701" /score="18.4402235" /energy="-10.1" /TU="U692" /idTUdmin="U691" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" CDS complement(890421..890894) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388769.1" /db_xref="EnsemblGenomes-Gn:BSU08890" /db_xref="EnsemblGenomes-Tr:CAB12717" /db_xref="GOA:P97029" /db_xref="SubtiList:BG12234" /db_xref="UniProtKB/Swiss-Prot:P97029" /translation="MSMKTKAAFHLVLFGLACWALISYFEASEGIASFFGTKSGGMVF DLNLTPFILFVAASAVYLYLQKKSRPARKQLLLPDEFEEQDEREQMMTAKACRASYIA VYFSLPAAAVLLIFYPLFQSRIPFFPIIIVFIIMIIQHLSYVISFKKNEKNSGAL*" /label="ygaO CDS" gene complement(890421..890894) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /label="ygaO gene" downshifts complement(890457) /Source="Nicolas_upshifts" /id="D453" /incds=0 /nref=105 /ntot=235 /MaxReadThrough="1.59724" /MaxDrop="4.17785" /score="7.33161195" /energy="-10.1" /TU="NA" /idTUdmin="U693" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(890896..891096) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative HTH-type transcriptional regulator" /protein_id="YP_003097697.1" /db_xref="EnsemblGenomes-Gn:BSU08899" /db_xref="EnsemblGenomes-Tr:CAX52584" /db_xref="GOA:C0H3X9" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="UniProtKB/Swiss-Prot:C0H3X9" /translation="MKNKVKELRARFGYSQEKLGETVGVTRQTVAAIEKGDYVPSLLL ALKICKAFSMKMEDVFWLEEEN*" /label="ygzD CDS" gene complement(890896..891096) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /label="ygzD gene" promotor_-10 complement(891125..891144) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(891139) /Source="Nicolas_upshifts" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(891157..891164) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 891220..891225 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 891239..891258 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 891239 /Source="Nicolas_upshifts" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="upshifts" tRNA 891290..891363 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(TCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Gly1 tRNA" gene 891290..891363 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /label="trnSL-Gly1 gene" S_feature 891364..891546 /Source="Nicolas_S_feature" /locus_tag="new_967139_967321" /HighExp="G135, G180, Oxctl, G150, Paraq, H2O2, C30, HPh, LPh, LBGexp" /AntisenseName="yhzB" /AntisenseCor="0.42714037049296899" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S311" CDS complement(891454..892077) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388771.1" /db_xref="EnsemblGenomes-Gn:BSU08900" /db_xref="EnsemblGenomes-Tr:CAB12718" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG13086" /db_xref="UniProtKB/Swiss-Prot:O31588" /translation="MNIKLDSVITERAAGLHAAAVIYENIEVGSSPQMLKGRLRLFQE SLFFDYADGGISDESFVKEWQKLFKQLNPSFEGETTPMEDMLVPISKEQFMESKDSAH DTIDFFALKYSLPIMIYDAGKLHEPVRISLGEKENILLFSDENGIFGDFKNSVNHYPV SNETKNMLQIIFFPPSIEKSSAVNLLSSLTKMFEQIHGGTHTVHWLT*" /label="yhzB CDS" gene complement(891454..892077) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /label="yhzB gene" downshifts complement(891469) /Source="Nicolas_upshifts" /id="D454" /incds=0 /nref=25 /ntot=165 /MaxReadThrough="2.50849" /MaxDrop="4.62652" /score="-8.52782087" /energy="-7.9" /TU="NA" /idTUdmin="U695" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 891503 /Source="Nicolas_upshifts" /id="D455" /incds=0 /nref=1 /ntot=88 /MaxReadThrough="4.14204" /MaxDrop="2.36986" /score="16.0836885" /energy="-15.5" /TU="U694" /idTUdmin="U692" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" S_feature 891548..892159 /Source="Nicolas_S_feature" /locus_tag="new_967323_967934" /HighExp="G180, G135, G150, Paraq, Oxctl, H2O2, LBGstat, Cold, LBGexp, S6" /AntisenseName="yhzB" /AntisenseCor="0.28959466335762701" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S312" promotor_-10 complement(892101..892120) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(892122) /Source="Nicolas_upshifts" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(892134..892141) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 892160..893320 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /EC_number="1.17.99.-" /function="10.3: tRNA and rRNA base modification" /experiment="publication(s) with functional evidences, PMID:8830270, 21502530, 26230193, 27638883, 28128549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830270, 21502530, 26230193, 27638883, 28128549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epoxyqueuosine reductase" /protein_id="NP_388772.2" /db_xref="EnsemblGenomes-Gn:BSU08910" /db_xref="EnsemblGenomes-Tr:CAB12719" /db_xref="GOA:P97030" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR004453" /db_xref="InterPro:IPR013542" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="PDB:5D08" /db_xref="PDB:5D0A" /db_xref="PDB:5D0B" /db_xref="PDB:5T8Y" /db_xref="SubtiList:BG12236" /db_xref="UniProtKB/Swiss-Prot:P97030" /translation="MNVYQLKEELIEYAKSIGVDKIGFTTADTFDSLKDRLILQESLG YLSGFEEPDIEKRVTPKLLLPKAKSIVAIALAYPSRMKDAPRSTRTERRGIFCRASWG KDYHDVLREKLDLLEDFLKSKHEDIRTKSMVDTGELSDRAVAERAGIGFSAKNCMITT PEYGSYVYLAEMITNIPFEPDVPIEDMCGSCTKCLDACPTGALVNPGQLNAQRCISFL TQTKGFLPDEFRTKIGNRLYGCDTCQTVCPLNKGKDFHLHPEMEPDPEIAKPLLKPLL AISNREFKEKFGHVSGSWRGKKPIQRNAILALAHFKDASALPELTELMHKDPRPVIRG TAAWAIGKIGDPAYAEELEKALEKEKDEEAKLEIEKGIELLKASGMTKQGLS*" /label="queG CDS" gene 892160..893320 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /label="queG gene" downshifts 893329 /Source="Nicolas_upshifts" /id="D456" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="5.29174" /MaxDrop="3.3561" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U694" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 893346..893358 /Source="Nicolas_upshift_promotors" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 893351 /Source="Nicolas_upshifts" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="upshifts" CDS 893387..894322 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388773.1" /db_xref="EnsemblGenomes-Gn:BSU08920" /db_xref="EnsemblGenomes-Tr:CAB12720" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG11811" /db_xref="UniProtKB/Swiss-Prot:O31589" /translation="MAGGVSLKYILEQLAEERLGFLVNGHAMRQESQVGDLKVMERKK KLLEKRKVDIIKAKAKAVINHVRVEDDGTTCLSYTIHYEYVCKEQDDSLYIEEHIEER MAFLYDHILISDQEIAKKPAGFHEGTSIIDYSEAEEEREAFGRAFQYDRLGAVQYAEK FWNKRNPAYKNFSDNCTNFISQCLHAGGAPMRGHPNRGSGWWMKQSSWSYSWTVAHSM KMYLSNSKAGLRAVRVKSAEELMPGDVICYDFEGDGRFNHTTIVVAKDKGNMPLVNAQ TYDSRMRYWSYEDSTAYTPSIRYAFFHIVDDTTKE*" /label="yhbB CDS" gene 893387..894322 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /label="yhbB gene" downshifts complement(893405) /Source="Nicolas_upshifts" /id="D457" /incds=0 /nref=2 /ntot=17 /MaxReadThrough="2.06584" /MaxDrop="3.33944" /score="-3.35852865" /energy="-6" /TU="NA" /idTUdmin="U695" /TUdmin="-1936" /isTUend="FALSE" /label="downshifts" promotor_-35 894306..894309 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 894324 /Source="Nicolas_upshifts" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 894325..894344 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 894360..894842 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /EC_number="2.1.1.207" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 20855540; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (cytidine(34)-2'-O)-methyltransferase" /protein_id="NP_388774.2" /db_xref="EnsemblGenomes-Gn:BSU08930" /db_xref="EnsemblGenomes-Tr:CAB12721" /db_xref="GOA:O31590" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR016914" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG11802" /db_xref="UniProtKB/Swiss-Prot:O31590" /translation="MNIVALHVVLYQPEIPANTGNIARTCAATNTTLHLIRPLGFSTD DKMLKRAGLDYWEFVNVVYHDSLEELFEAYKKGKFFFITKFGQQPHTSFDYTDLDEDY FFVFGRETSGLPKDLIQNNMDRCLRLPMTEHVRSLNLSNTAAILVYEALRQQNYRDLK *" /label="trmL CDS" gene 894360..894842 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /label="trmL gene" downshifts 894825 /Source="Nicolas_upshifts" /id="D458" /incds=0 /nref=203 /ntot=259 /MaxReadThrough="4.6846" /MaxDrop="7.03587" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U696" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 894892..895608 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="NP_388775.1" /db_xref="EnsemblGenomes-Gn:BSU08940" /db_xref="EnsemblGenomes-Tr:CAB12722" /db_xref="InterPro:IPR025063" /db_xref="SubtiList:BG12237" /db_xref="UniProtKB/Swiss-Prot:P97032" /translation="MLCFVFGLNNVTVLCYNVPIKGAGLMEEQLISKKELLERTSISY GQLYRWKRKNLIPEEWFIRKSTFTGQETFFPREEILKRISMIQKMKENLSLDEMREML SPKMKDVSMTADELLHKGLVSRPALEAYSEDGGSPVFSSSDLLSLFVLEGLLQSGNVS LAEAKMAAEVLKKHDTEEIEKQTELIVLRKLGVTTCFIAAAADSILFESSVKVVERVD LLKASEELKTTFMQEGHQWM*" /label="yhbD CDS" gene 894892..895608 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /label="yhbD gene" promotor_-35 894912..894919 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 894934..894953 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 894935 /Source="Nicolas_upshifts" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="upshifts" CDS 895599..896312 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388776.1" /db_xref="EnsemblGenomes-Gn:BSU08950" /db_xref="EnsemblGenomes-Tr:CAB12723" /db_xref="InterPro:IPR007607" /db_xref="SubtiList:BG10802" /db_xref="UniProtKB/Swiss-Prot:P39132" /translation="MDVVEKLVINGSGSSKGGTFQSVEINGSGTVAGDVECDTFSFNG NGKADGSVKAKAVTISGSGKIHGDVEAESIRMNGTGFIQGEVSAKQLKIAGSSTFGGT VKADGIDISGKAVMEADCETETFQSEGKCKISGLLNADQVIIKLSAGESYAREIGCRH LQVTCRKGMLTLLRLMPQPVLTAELIEGDVIELTNTKAKTVRGNKVIIGPDCQIETVE YSGDYTCDPSASVETSTKL*" /label="yhbE CDS" gene 895599..896312 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /label="yhbE gene" CDS 896324..897031 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388777.2" /db_xref="EnsemblGenomes-Gn:BSU08960" /db_xref="EnsemblGenomes-Tr:CAB12724" /db_xref="SubtiList:BG10803" /db_xref="UniProtKB/Swiss-Prot:P39133" /translation="METTKLGNLKLYGAGHAAGGAYHNVSIKGEGIVGEGLSAVGCRI YGTGLFLGKAETERLRVLGESECKGDLTAGKINIYGTMKVSGSLQFDRFNLKGQTEIG GNMTGESCDVKGKLSVIGDCETEMFHVTGCVDVSGLLNSGEIKLGLSHDISHVQEIGG TTITVKRRASFFSRKKGKLIADVIEGDRVYLENTEAAVVRGKEVIIGPGCSIGTIEYE YKCECDPHSQIKEKTKL*" /label="yhbF CDS" gene 896324..897031 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /label="yhbF gene" downshifts 896915 /Source="Nicolas_upshifts" /id="D459" /incds=1 /nref=1 /ntot=127 /MaxReadThrough="4.34704" /MaxDrop="2.64409" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 896959 /Source="Nicolas_upshifts" /id="D460" /incds=1 /nref=2 /ntot=35 /MaxReadThrough="4.02504" /MaxDrop="3.21894" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 897025 /Source="Nicolas_upshifts" /id="D461" /incds=0 /nref=2 /ntot=41 /MaxReadThrough="1.06365" /MaxDrop="3.74046" /score="45.497414" /energy="-15.3" /TU="NA" /idTUdmin="U698" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(897058..897233) /Source="Nicolas_S_feature" /locus_tag="new_972833_973008_c" /HighExp="M9-stat, BC, S4, T0.30H, LoTm, Lbstat, S2, BT, HiOs, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99846699999999999" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S313" downshifts complement(897101) /Source="Nicolas_upshifts" /id="D462" /incds=0 /nref=63 /ntot=220 /MaxReadThrough="3.38525" /MaxDrop="4.33005" /score="18.2489321" /energy="-13.5" /TU="U699" /idTUdmin="U699" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(897225..897244) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(897233) /Source="Nicolas_upshifts" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(897259..897266) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 897298..897303 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 897319..897337 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 897319 /Source="Nicolas_upshifts" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="upshifts" CDS 897381..899276 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8626065, 12662922, 25983726, 27806131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8626065, 12662922, 25983726, 27806131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine protein kinase (involved in sporulation)" /protein_id="NP_388778.1" /db_xref="EnsemblGenomes-Gn:BSU08970" /db_xref="EnsemblGenomes-Tr:CAB12725" /db_xref="GOA:P39134" /db_xref="InterPro:IPR010650" /db_xref="InterPro:IPR013153" /db_xref="InterPro:IPR016230" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10804" /db_xref="UniProtKB/Swiss-Prot:P39134" /translation="MDILKKIEKYREEEQRLKWEGTFADYLEIIKENPMVAQSAHSRV FNMIKDSGIEEIDGRKKYSFFDRELFGLEESLERLVEEYFHPAAKRLDVRKRILLLMG PVSGGKSTLVTMLKKGLEAYTLTDNGAVYAIKGCPMHEDPLHLIPHHLRDDFYREYGI RIEGSLSPLNVMRLEEEYGGRIEDVKVERIFFSEDKRTGIGTFSPSDPKSQDIADLTG SIDFSTIAEYGSESDPRAYRFDGELNKANRGMMEFQEMLKCDEKFLWHLLSLTQEGNF KAGRFALISADELIVAHTNETEYRSFISNKKNEALHSRIIVMPVPYNLKVSEEERIYE KMIAESDVADVHIAPHTLKVAAMFSILTRLKEPKRSDIDLVKKMRLYDGESVEGYNSV DVEDMKKEYNDEGMSGIDPRYVINRISSTIIRKNMESINSLDVLRSLKEGLDQHPSIS SEDRERYLNFISAARKEYDDIAKKEVQKAFVYSYEESAKTLMDNYLDNVEAYCNKNKL RDPLTGEEMNPDEKLMRSIEEQIGISENAKKAFREEILIRISAYARKGKRFDYNSHER LREAIQKKLFADLKDVVKITTSTKTPDEQQLKKVNEVVARLIDEHGYNSTSANELLKY VGSLLNR*" /label="prkA CDS" gene 897381..899276 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /label="prkA gene" promotor_no_box 897823..897923 /Source="Nicolas_upshift_promotors" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 897883 /Source="Nicolas_upshifts" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 897949 /Source="Nicolas_upshifts" /id="D463" /incds=1 /nref=5 /ntot=18 /MaxReadThrough="7.33384" /MaxDrop="5.65132" /score="45.497414" /energy="-15.3" /TU="U700" /idTUdmin="U701" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 899269 /Source="Nicolas_upshifts" /id="D464" /incds=0 /nref=11 /ntot=57 /MaxReadThrough="6.19375" /MaxDrop="4.381" /score="-0.497429548" /energy="-10.6" /TU="U700" /idTUdmin="U703" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 899333..899338 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 899354..899372 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 899357..899455 /Source="Nicolas_S_feature" /locus_tag="new_975132_975230" /HighExp="S6, S7, S5, S8, S4, S3, BT, LoTm, B36, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.971, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S314" upshifts 899357 /Source="Nicolas_upshifts" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="upshifts" CDS 899456..900634 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11988534, 12662922, 14523133, 25983726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 12662922, 14523133, 25983726; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination" /protein_id="NP_388779.1" /db_xref="EnsemblGenomes-Gn:BSU08980" /db_xref="EnsemblGenomes-Tr:CAB12726" /db_xref="InterPro:IPR006698" /db_xref="InterPro:IPR014230" /db_xref="SubtiList:BG11238" /db_xref="UniProtKB/Swiss-Prot:P45742" /translation="MSQNDSGHFLISEENWSLHRKGFDDQQRHQKKVQEAIKNNLPDL VTEESIIMSNGKDVVKIPIRSLDEYKIRYNYDKNKHVGQGDGESQVGDVVARDGSDKK QGPGKGQGAGDQAGEDYYEAEVSLMDLEEALFKELELPNLQQKERDNIIHTDIEFNDI RKTGLTGNIDKKRTMMSAFKRNAMSGKPSFYPIYPEDLKYKTWNDITKPESKAVVLAM MDTSGSMGVWEKYMARSFFFWMTRFLRTKYETVEIEFIAHHTEARVVSEEDFFSKGES GGTICSSVYRKSLELIDEKYNPARYNIYPFHFSDGDNLTSDNARCVKLVNDIMKKANL FCYGEVNQYNRHSTLMSAYKNVKDEKFKYYILKQKSDVFQALKNFFRNEESGVSHQFS *" /label="yhbH CDS" gene 899456..900634 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /label="yhbH gene" promotor_-35 899654..899657 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 899672..899691 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 899676 /Source="Nicolas_upshifts" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(899917) /Source="Nicolas_upshifts" /id="D465" /incds=1 /nref=1 /ntot=23 /MaxReadThrough="2.79078" /MaxDrop="2.94521" /score="-7.1109433" /energy="-11.2" /TU="NA" /idTUdmin="U699" /TUdmin="-3014" /isTUend="FALSE" /label="downshifts" downshifts 900613 /Source="Nicolas_upshifts" /id="D466" /incds=0 /nref=63 /ntot=180 /MaxReadThrough="1.86673" /MaxDrop="8.19565" /score="27.3980811" /energy="-5.6" /TU="NA" /idTUdmin="U702" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 900721..900728 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 900743..900762 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 900743 /Source="Nicolas_upshifts" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" CDS 900794..901258 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)induced by acid stress" /protein_id="NP_388780.1" /db_xref="EnsemblGenomes-Gn:BSU08990" /db_xref="EnsemblGenomes-Tr:CAB12727" /db_xref="GOA:O31592" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13003" /db_xref="UniProtKB/Swiss-Prot:O31592" /translation="MTESERALLTFEQLFDTSRAIYKKQKKILEIVLEPFDITVLQYL LMFKIHQSGSTPLSKLAMSLDLKPASVTRMTDILYKRQLMNRYDSPDDRRIVMIQLTE EGEELIEKAAVQYAKMGAGLYQKLDTSQLQYLRKLAGSLTKLAEGCSEKSGN*" /label="yhbI CDS" gene 900794..901258 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /label="yhbI gene" promotor_-35 901083..901089 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 901104..901122 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 901117 /Source="Nicolas_upshifts" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 901267..901273 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 901287..901298 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 901293 /Source="Nicolas_upshifts" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" CDS 901294..901959 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane fusion protein; putative exporter subunit (benzoate transcriptome)" /protein_id="NP_388781.1" /db_xref="EnsemblGenomes-Gn:BSU09000" /db_xref="EnsemblGenomes-Tr:CAB12728" /db_xref="GOA:O31593" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG13004" /db_xref="UniProtKB/Swiss-Prot:O31593" /translation="MIEDETKGENKMNRGRLILTNIIGLIVVLAIIAGGAYYYYQSTN YVKTDEAKVAGDMAAITAPAAGKVSDWDLDEGKTVKKGDTVAKIKGEQTVDVKSIMDG TIVKNEVKNGQTVQAGTTIAQTIDMDNLYITANIKETDIADIEVGNSVDVVVDGDPDT TFDGTVEEIGYATNSTFDMLPSTNSSGNYTKVTQKVPVKISIKNPSDKVLPGMNASVK ISE*" /label="yhbJ CDS" gene 901294..901959 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /label="yhbJ gene" CDS 902000..903598 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter (benzoate transcriptome)" /protein_id="NP_388782.1" /db_xref="EnsemblGenomes-Gn:BSU09010" /db_xref="EnsemblGenomes-Tr:CAB12729" /db_xref="GOA:P54585" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11579" /db_xref="UniProtKB/Swiss-Prot:P54585" /translation="MATGKEKNAKNPMSLLIVLMAGLFLAILNQTLLNVAMPHLMTEF GVSATTIQWLTTGYMLVNGVLIPLSAFLITRFGQRSLFLVAMFCFTLGTLVCGIAPNF STMLIGRLIQAVGGGILQPLVMTTILLIFPPESRGKGMGIFGLAMMFAPAVGPTLSGW IIEHYTWRIMFYGLVPIGAIVIIVAFFIFKNMVEPQKIKLDTLGAILSIVGFASLLYG VSEAGSDGWTDPIVLSTVIIGAIAIVAFVVQQLRHDDPMLDFRVFKYDIFSLSSVINI IITVALYTGMFLLPIYLQNLVGFTALQSGLLLLPGAIVMLIMSPISGILFDKFGPRPL AIIGLLVTVVTTYQYTQLTIDTPYTHIMLIYSIRAFGMSLLMMPVMTAGMNQLPARLN SHGTAMSNTLRQISGSIGTSLITTIYTNRTTFHYSQIADKTSTADPNFLHAFQNAVSN LMVNMNVSYDTAKTYVYSHIYKHASLDSNVMGINDAFMWATLFCVAGLILSIFLRDVR KDKLRKKKKEELSLLPAPKEAKES*" /label="yhcA CDS" gene 902000..903598 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /label="yhcA gene" CDS 903621..904151 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /EC_number="1.6.5.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15754243, 18041955, 17951395, 19665595, 20011599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:quinone oxidoreductase associated to benzoate stress" /protein_id="NP_388783.1" /db_xref="EnsemblGenomes-Gn:BSU09020" /db_xref="EnsemblGenomes-Tr:CAB12730" /db_xref="GOA:P54586" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11580" /db_xref="UniProtKB/Swiss-Prot:P54586" /translation="MKIYVVYDSEGEHTKVLAEAIAEGARENDAAEVFIDHVDQADIR KLKDMDAIIWGCPGHFGTISSGLKTWIDRLGYLWAEGELINKVGAVFCTTATTHGGLE MTMHNLITPMFHQGMIVVGLPGNVPENALYGSYYGAGVTCPVDSDELMSEEGIQLGRA LGRRVSQVTGNLTAGQ*" /label="yhcB CDS" gene 903621..904151 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /label="yhcB gene" CDS 904164..904538 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical membrane protein" /protein_id="NP_388784.1" /db_xref="EnsemblGenomes-Gn:BSU09030" /db_xref="EnsemblGenomes-Tr:CAB12731" /db_xref="GOA:P54587" /db_xref="SubtiList:BG11581" /db_xref="UniProtKB/Swiss-Prot:P54587" /translation="MAIIIAIIAAVIVIAALITFNVRNASPGPEKQEATDRIAPPEEE KNEAHYPAEARAAEHTPSVVKNDSPKEKRDTMGDDIYRQALQKFKHSDEVHAEEEVTE ESDKMQDRSYRDALLSMKNKKK*" /label="yhcC CDS" gene 904164..904538 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /label="yhcC gene" downshifts 904527 /Source="Nicolas_upshifts" /id="D467" /incds=0 /nref=32 /ntot=145 /MaxReadThrough="1.78742" /MaxDrop="5.9171" /score="13.777309" /energy="-14.4" /TU="NA" /idTUdmin="U704" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 904538..904693 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388785.1" /db_xref="EnsemblGenomes-Gn:BSU09040" /db_xref="EnsemblGenomes-Tr:CAB12732" /db_xref="SubtiList:BG11582" /db_xref="UniProtKB/Swiss-Prot:P54588" /translation="MKKANPFTHAGLPFLLFPSIMFLSNKSMEYVVFHLDLVYYVTHT PRIFSGR*" /label="yhcD CDS" gene 904538..904693 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /label="yhcD gene" promotor_-35 904628..904634 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 904649..904668 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 904659 /Source="Nicolas_upshifts" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="upshifts" CDS 904698..905459 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane orphan protein" /protein_id="NP_388786.1" /db_xref="EnsemblGenomes-Gn:BSU09050" /db_xref="EnsemblGenomes-Tr:CAB12733" /db_xref="GOA:P54589" /db_xref="SubtiList:BG11583" /db_xref="UniProtKB/Swiss-Prot:P54589" /translation="MNSFLGLLKKDIKLSRMWLLVWICGIIFLLGTGHIIASRTKEPL VIFGFFVAVAFFLLFLSPVFVFYHLRKEGKSQLWLYNPNGGLWLFSSKLAASLLYQFV IQLALTAYGIWMYHMLSVKNLLEHQVDITSTVALLNMYGLISSLDMSVTVIVFWTVFH SLRNWRGMRWAAMVLLVAMWLFFDEYIISPLVESQKHFWPVTVYCNFDFHFHNVWRLE LKPIHLSVLGFPIAIVITFLLLIMASKLLDRKVEV*" /label="yhcE CDS" gene 904698..905459 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /label="yhcE gene" promotor_-10 complement(905011..905029) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(905025) /Source="Nicolas_upshifts" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(905045..905050) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 905462..905827 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_388787.1" /db_xref="EnsemblGenomes-Gn:BSU09060" /db_xref="EnsemblGenomes-Tr:CAB12734" /db_xref="GOA:P54590" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11584" /db_xref="UniProtKB/Swiss-Prot:P54590" /translation="MDNQFQSSKPIYLQIADQIFYRLVRKELLPGDKLPSVREMAIQT KVNPNTIQRTYSEMERLGIVETRRGQGTFIAEKAEIVDELKDKLTREVLEGFVKQMKE LGLTKEEMLEGIKTFTEGG*" /label="yhcF CDS" gene 905462..905827 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /label="yhcF gene" CDS 905829..906527 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter ATP-binding protein" /protein_id="NP_388788.1" /db_xref="EnsemblGenomes-Gn:BSU09070" /db_xref="EnsemblGenomes-Tr:CAB12735" /db_xref="GOA:P54591" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11585" /db_xref="UniProtKB/Swiss-Prot:P54591" /translation="MEIKLEHVSKKYGRHTAVNDVSITLSSGRIYGLIGPNGSGKSTT LKMMAGLLFPTSGFVKVDEEQVTREMVRQTAYLTELDMFYPHFTVKDMVNFYQSQFPD FHTEQVYKLLNEMQLNPEKKIKKLSKGNRGRLKIVLALARRADVILLDEPFSGLDPMV RDSIVNSLVSYIDFEQQIVVIATHEIDEIETLLDEVIILANGEKVAQREVEDIREQEG MSVLQWFKSKMEVC*" /label="yhcG CDS" gene 905829..906527 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /label="yhcG gene" CDS 906544..907461 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7476193, 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388789.1" /db_xref="EnsemblGenomes-Gn:BSU09080" /db_xref="EnsemblGenomes-Tr:CAB12736" /db_xref="GOA:P54592" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11586" /db_xref="UniProtKB/Swiss-Prot:P54592" /translation="MKTVLELKNVTKNIRGRTIIDDLSFTIREGEVFGFLGPNGAGKT TTIRMMVGLMKLSKGDVLICGQSITKEYAKAIKHIGAIVENPELYKFLSGYKNLQQFA RMVKGVTKEKIDEVVELVGLTDRIHDKVKTYSLGMRQRLGLAQCLLHDPKVLILDEPT NGLDPAGIREIRDHLKKLTRERGMAVIVSSHLLSEMELMCDRIAILQKGKLIDIQNVK DENIDENDTYFFQVEQPSEAATVLNQYDLLSKTNGVEIKLAKEEVPAVIELLVMQQIR IYEVKVITKSLEDRFLEMTGETKEEVQHA*" /label="yhcH CDS" gene 906544..907461 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /label="yhcH gene" CDS 907454..908395 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15870467, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_388790.1" /db_xref="EnsemblGenomes-Gn:BSU09090" /db_xref="EnsemblGenomes-Tr:CAB12737" /db_xref="GOA:P54593" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11587" /db_xref="UniProtKB/Swiss-Prot:P54593" /translation="MLNLIYNEWLKIFSRAGTWVMIGILGLTMVGFAFLANHFSAGES NSHWKQELQAQNAELKKEIKEDPSLKDGYKETITLNDYRIEHNIPSDTGYTVWSYVTD SANFTILTGLFTIIIAAGIVANEFNWGTIKLLMIRPLSRFQILMSKYITVLLFGLLLL LILFIGSTLLGLIFFGTGGETAANIHLIYKDGHVIEQNMMGHLATTYLSESVSALMVA TMAFMLSAVFRNSSLAVGFSIFLLVAGTTATAFIAAKFDWAKYILFANVDLTQYVDGT PLIKGMTMTFSLVMLAIYFIIFLLLAFGIFMKRDIAN*" /label="yhcI CDS" gene 907454..908395 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /label="yhcI gene" downshifts 908377 /Source="Nicolas_upshifts" /id="D468" /incds=0 /nref=43 /ntot=186 /MaxReadThrough="2.67567" /MaxDrop="4.46232" /score="20.0218504" /energy="-13.6" /TU="NA" /idTUdmin="U707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(908487..908690) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12493834, 16352840, 22128343, 25851716" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12493834, 16352840, 22128343, 25851716; Product type f: factor" /codon_start=1 /transl_table=11 /product="major cold-shock protein, RNA helicase co-factor, RNA co-chaperone" /protein_id="NP_388791.1" /db_xref="EnsemblGenomes-Gn:BSU09100" /db_xref="EnsemblGenomes-Tr:CAB12738" /db_xref="GOA:P32081" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="PDB:1CSP" /db_xref="PDB:1CSQ" /db_xref="PDB:1NMF" /db_xref="PDB:1NMG" /db_xref="PDB:2ES2" /db_xref="PDB:2F52" /db_xref="PDB:2I5L" /db_xref="PDB:2I5M" /db_xref="PDB:3PF4" /db_xref="PDB:3PF5" /db_xref="SubtiList:BG10824" /db_xref="UniProtKB/Swiss-Prot:P32081" /translation="MLEGKVKWFNSEKGFGFIEVEGQDDVFVHFSAIQGEGFKTLEEG QAVSFEIVEGNRGPQAANVTKEA*" /label="cspB CDS" gene complement(908487..908690) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /label="cspB gene" downshifts complement(908501) /Source="Nicolas_upshifts" /id="D469" /incds=0 /nref=169 /ntot=281 /MaxReadThrough="5.28215" /MaxDrop="9.14889" /score="33.2405587" /energy="-13.1" /TU="U710" /idTUdmin="U710" /TUdmin="-48" /isTUend="FALSE" /label="downshifts" S_feature complement(908691..908818) /Source="Nicolas_S_feature" /locus_tag="new_984466_984593_c" /HighExp="BC, C90, GM 15, BI, T-1.10H, UNK1, S1, Sw, nit, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S315" misc_feature 908778..908789 /Source="Nicolas_upshift_promotors" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 908795 /Source="Nicolas_upshifts" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(908807..908826) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(908818) /Source="Nicolas_upshifts" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(908820..909958) /Source="Nicolas_S_feature" /locus_tag="new_984595_985733_c" /HighExp="C30, G180, G150, Oxctl, G135, Paraq, HPh, LPh, dia0, Lbexp" /AntisenseName="yhcJ" /AntisenseCor="0.25433958616302499" /AntisenseRegPval="-4.5999999999999996" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S316" promotor_-35 complement(908840..908845) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 908985..908992 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 909007..909025 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 909014 /Source="Nicolas_upshifts" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="upshifts" S_feature 909015..909125 /Source="Nicolas_S_feature" /locus_tag="new_984790_984900" /HighExp="Diami, dia15, dia5, H2O2, Salt, C90, Paraq, UNK1, T-4.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S317" CDS 909126..909956 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_388792.2" /db_xref="EnsemblGenomes-Gn:BSU09110" /db_xref="EnsemblGenomes-Tr:CAB12739" /db_xref="GOA:P54594" /db_xref="InterPro:IPR004872" /db_xref="SubtiList:BG11588" /db_xref="UniProtKB/Swiss-Prot:P54594" /translation="MKKWLICSFVLVLLVSFTACSPSAEHESIKIGIAESDGAIWNYI AQKAEEAGLDIQLIPFSDYAESDIALANKEIDANAFQTISYFQSFTEKYKLNLAPLGT TYITPMGIYSKRYERIRDISRGAVVSVPDKAFDFGRALTVLQEAGLLTLKNGFNGTGS VDMIKDNPRHLKLKAVRQQDAVSGADVFVMKPSEAKKAGLNPKKHTLKSGGLMSEEEM NLIVVRAEDQDREALQTILELYQADDTAAFIEKEYQGDLVPAFLPLKRLSDWKNEFEH *" /label="yhcJ CDS" gene 909126..909956 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /label="yhcJ gene" downshifts 909915 /Source="Nicolas_upshifts" /id="D470" /incds=0 /nref=38 /ntot=203 /MaxReadThrough="2.83059" /MaxDrop="3.90173" /score="-4.94928928" /energy="-7.3" /TU="NA" /idTUdmin="U711" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(909959..911038) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_388793.1" /db_xref="EnsemblGenomes-Gn:BSU09120" /db_xref="EnsemblGenomes-Tr:CAB12740" /db_xref="GOA:P54595" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG11589" /db_xref="UniProtKB/Swiss-Prot:P54595" /translation="MLKELFVNLTILITFNYLFTHLFKERLVHKKDSISFQAVKGLAC GLLGVILMVFGFTYQHSIIDLRNIPIMIAALYGGWVSTATALAMITAGRLLITMNTSA LYSVIIICIAAIPSLIVSRRKKVQLKHAFYLLIITNSLISFSFYFLIDLHSYELHLYF WIISIAGGMLSLYIIDHETNAHLLFKQYKFQAHFDFLTGVYNRRKFEETTKALYQQAA DTPHFQFALIYMDIDHFKTINDQYGHHEGDQVLKELGLRLKQTIRNTDPAARIGGEEF AVLLPNCSLDKAARIAERIRSTVSDAPIVLTNGDELSVTISLGAAHYPNNTEQPGSLP ILADQMLYKAKETGRNRVCFSEKKE*" /label="dgcK CDS" gene complement(909959..911038) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /label="dgcK gene" promotor_-10 complement(911048..911067) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-10" upshifts complement(911069) /Source="Nicolas_upshifts" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="upshifts" promotor_-35 complement(911083..911087) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-35" promotor_-35 911145..911152 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 911166..911185 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 911172 /Source="Nicolas_upshifts" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="upshifts" CDS 911211..912602 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12193636, 15262924, 15849754, 16513748, 16850406, 19508281" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 15262924, 15849754, 16513748, 16850406, 19508281; Product type t : transporter" /codon_start=1 /transl_table=11 /product="(sodium)-cystine symporter" /protein_id="NP_388794.1" /db_xref="EnsemblGenomes-Gn:BSU09130" /db_xref="EnsemblGenomes-Tr:CAB12741" /db_xref="GOA:P54596" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11590" /db_xref="UniProtKB/Swiss-Prot:P54596" /translation="METLLVVLHVFILFLLILGLFVMQKKHVSFSKRVFTALGLGIVF GFALQLIYGPTSNIVIQTADWFNIAGGGYVKLLQMVVMPLVFISILGAFTKLKLTKNL GKISGLIIGILVATTAVAAAVGIASALSFDLQAIQVDQGSTELSRGQELQQKSEDMTA KTLPQQIVELLPGNPFLDFTGARPTSTIAVVIFAAFLGVAFLGVKHKQPEQAETFKKL VDAVYAIVMRVVTLILRLTPYGVLAIMTKTIATSDLDSILKLGMFVIASYAALITMFI IHLLLLTFSGLNPVIYLKKAVPVLVFAFTSRSSAGALPLNIKTQRSMGVPEGIANFAG SFGLSIGQNGCAGIYPAMLAMMIAPTVGQNPFDPVFIITVIAVVAISSFGVAGVGGGA TFAALLVLSSLNMPVALAGLLISIEPLIDMGRTALNVSGSMTSGLITSKVTKEIDQGA FHDQSRVIEAEEA*" /label="tcyP CDS" gene 911211..912602 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /label="tcyP gene" S_feature complement(912238..912641) /Source="Nicolas_S_feature" /locus_tag="new_988013_988416_c" /HighExp="S8, S6, Etha, S5, S7, S4, ferm, nit, Salt, S3" /AntisenseName="tcyP" /AntisenseCor="-0.40132140065468203" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S318" downshifts 912581 /Source="Nicolas_upshifts" /id="D471" /incds=0 /nref=58 /ntot=164 /MaxReadThrough="2.37899" /MaxDrop="5.34563" /score="19.9118074" /energy="-12.8" /TU="NA" /idTUdmin="U713" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(912642..913097) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21625606" /codon_start=1 /transl_table=11 /product="expressed protein of unknown function" /protein_id="NP_388795.1" /db_xref="EnsemblGenomes-Gn:BSU09140" /db_xref="EnsemblGenomes-Tr:CAB12742" /db_xref="SubtiList:BG11591" /db_xref="UniProtKB/Swiss-Prot:P54597" /translation="MLFNQRRGISPAALIIGSTMLITALSPQIRQRISGFITGQMNRR NSENNTFDASNVGNMVKQAFSGSSGSSGDNQDRSQHQSQRQNGRQHQHAGQQQPQHQH TQSQTRQTETAAKKRQPHYAEPIHFEQNAMNVMDDNTMMEMLEDLEPGR*" /label="yhcM CDS" gene complement(912642..913097) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /label="yhcM gene" promotor_-10 complement(913112..913130) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(913140) /Source="Nicolas_upshifts" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(913145..913151) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 913189..913195 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 913209..913220 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 913213 /Source="Nicolas_upshifts" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="upshifts" CDS 913247..913816 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9611260, 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_388796.2" /db_xref="EnsemblGenomes-Gn:BSU09150" /db_xref="EnsemblGenomes-Tr:CAB12743" /db_xref="GOA:P54598" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG11592" /db_xref="UniProtKB/Swiss-Prot:P54598" /translation="MFGKKQVLASVLLIPLLMTGCGVADQGEGRRDNNDVRNVNYRNP ANDDMRNVNNRDNVDNNVNDNVNNNRVNDDNNNDRKLEVADEAADKVTDLKEVKHADI IVAGNQAYVAVVLTNGNKGAVENNLKKKIAKKVRSTDKNIDNVYVSANPDFVERMQGY GKRIQNGDPIAGLFDEFTQTVQRVFPNAE*" /label="yhcN CDS" gene 913247..913816 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /label="yhcN gene" promotor_-35 913443..913449 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 913460 /Source="Nicolas_upshifts" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 913463..913474 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 913791 /Source="Nicolas_upshifts" /id="D472" /incds=0 /nref=26 /ntot=183 /MaxReadThrough="1.84697" /MaxDrop="7.80159" /score="33.0647397" /energy="-12.9" /TU="NA" /idTUdmin="U715" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-35 913859..913868 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 913882..913901 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 913892 /Source="Nicolas_upshifts" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="upshifts" CDS 913937..914905 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein (sporulation germination island)" /protein_id="NP_388797.2" /db_xref="EnsemblGenomes-Gn:BSU09165" /db_xref="EnsemblGenomes-Tr:CAB12744" /db_xref="SubtiList:BG11593" /db_xref="UniProtKB/Swiss-Prot:P54599" /translation="MRDGIGKRAASALFLCGVLVMLAVSSAIVSSAMYILSFPGQASG ITKEQVTKHMKKESFKQADIYYTSKEKSLLPLTKETLEYAVSINQIMIGYSNQKPIDI IFFPNEKQMEAYSGLLDVVGFYSEREQLIGLLPEEKKKLLEGDEVAVYLYQRLLIHEY SHHAFHQKLKELETDPDEFPLWFHEGLSEWIANYELLIDPITFSVVPFDRLQTDRDWQ EARAEYDTDVYLQSFYMIDELTDKYGKDIISEMIKETAKKGDFEKGFKSATKESLDQF EKDFKKKFEKNSAALDSIYPMPLLLVKSLLTHSALCRRHLSLGRGE*" /label="yhcO CDS" gene 913937..914905 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /label="yhcO gene" downshifts 914781 /Source="Nicolas_upshifts" /id="D473" /incds=1 /nref=28 /ntot=62 /MaxReadThrough="1.51621" /MaxDrop="5.75619" /score="6.21571271" /energy="-16.1" /TU="NA" /idTUdmin="U717" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(914837..915490) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_388799.1" /db_xref="EnsemblGenomes-Gn:BSU09180" /db_xref="EnsemblGenomes-Tr:CAB12746" /db_xref="GOA:P54601" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG11595" /db_xref="UniProtKB/Swiss-Prot:P54601" /translation="MDQFNQQQQSQMNKGIPGKPHKNHGGHEMFDMHEVLSGTLTVLD QFMMLRQFCKDQELLNILDRQHQFITSQYNITAECFKTGSEPSQKTATYMMKEDNQTV YGMQPSQPKKPVQSMNDIDDSIISRQMLCAIKAQASMLTMASLEMTNPAVRRVLSAQI QEYVEMAFEIFLYQNKHGYYQVPQLDAQDMEQLRNSFAPAQGQMPPTQGGMGQQGLH* " /label="yhcQ CDS" gene complement(914837..915490) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /label="yhcQ gene" downshifts complement(914854) /Source="Nicolas_upshifts" /id="D474" /incds=0 /nref=15 /ntot=57 /MaxReadThrough="4.13099" /MaxDrop="4.95733" /score="8.67086892" /energy="-12.9" /TU="U718" /idTUdmin="U718" /TUdmin="-546" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(915521..915532) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(915523) /Source="Nicolas_upshifts" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(915547..915553) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 915562..915570 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 915573..919226 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15292138, 21800427, 22020651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292138, 21800427, 22020651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="non specific extracellular Ca2+-dependent endonuclease cleaving RNA and DNA" /protein_id="NP_388800.1" /db_xref="EnsemblGenomes-Gn:BSU09190" /db_xref="EnsemblGenomes-Tr:CAB12747" /db_xref="GOA:P54602" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR019948" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR035437" /db_xref="InterPro:IPR035451" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG11596" /db_xref="UniProtKB/Swiss-Prot:P54602" /translation="MLSVEMISRQNRCHYVYKGGNMMRRILHIVLITALMFLNVMYTF EAVKAAEPQQPISIEKAIQQKEGQALVEGYAVGQAVSPQHYKLTSPFSNDYNVALADR KNKTSPEHILPVQIPSAFRSQFGLQTNPLLLGKKITVQGKLENYFNTTGLKNVQSMNV TDDTKTPPAEQQVTINEARGRLNEEVTIKGIITADQNAIGGGKLSTFLQDETGGINIY SPSPEQFPELKEGMDVTVTGKITSYQGLKEIVPNSSGIKINQSNQSLPAPKHLTINEL INGSLGDQYEGRLVKLTAFVSSIPSSPAGGGYNVTMIDDDHHAMTLRVMNETGVINEL DEGKWYEFTGVLSRYQTFQLLPRKSADLKLLEEQPAPPSAEGEYEGIVDRVVDGDTIH LKSPVLGTTKIRFVNVDAPETYHTPKNDADENQLRFGKKASDYLKTVLSPGDKITVKV GSEAKDSYGRLLGQVITESGSNVNLELVKNGYAPTYFIWPVDNEEDYQQFQAAVAAAK KDQKGIWNENDPLMEMPFEFRAREQGKGLTRYVGDSSNKTYVQPADWKKIAVENRIFF ASASEAESAGYKKRQTAPQEHVPLRILSMNDLHGKIDQQYELDLDGNGTVDGTFGRMD YAAAYLKEKKAEKKNSLIVHAGDMIGGSSPVSSLLQDEPTVELMEDIGFDVGTVGNHE FDEGTDELLRILNGGDHPKGTSGYDGQNFPLVCANCKMKSTGEPFLPAYDIINVEGVP VAFIGVVTQSAAGMVMPEGIKNIEFTDEATAVNKAAEELKKKGVKAIAVLAHMSAEQN GNAITGESADLANKTDSEIDVIFAAHNHQVVNGEVNGKLIVQAFEYGKAIGVVDVEID KTTKDIVKKSAEIVYVDQSKIEPDVSASAILKKYETIAEPIISEVVGEAAVDMEGGYS NDGDTPLGNLIADGMRAAMKTDFALMNGGGIREALKKGPITWGDLYNIQPFGNVLTKL EIKGKDLREIINAQISPVFGPDYSISGFTYTWDKETGKAVDMKMADGTEIQPDATYTL TVNNFMATATGAKYQPIGLLGKNPVTGPEDLEATVEYVKSFDEPIAYTKEGRIKLAEA SDIEDPVTEDPITEEPGDDPGTEDPIKEDPRPGEDLPDIKETPGTAPVHQLPPSAISR FNEIPINNTKTADTANSISTLPLQTETAESGSDHQLPDTSAGYYNFMVIGAAVTLSGT YLYVRRKRSASRT*" /label="mncR CDS" gene 915573..919226 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /label="mncR gene" promotor_-10 915581..915599 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 915596 /Source="Nicolas_upshifts" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="upshifts" CDS 919223..919819 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /EC_number="3.4.22.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12823805, 21800427, 22020651, 25038633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12823805, 21800427, 22020651, 25038633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sortase A" /protein_id="NP_388801.1" /db_xref="EnsemblGenomes-Gn:BSU09200" /db_xref="EnsemblGenomes-Tr:CAB12748" /db_xref="GOA:P54603" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG11597" /db_xref="UniProtKB/Swiss-Prot:P54603" /translation="MKKVIPLFIIAAGLVIAGYGGFKLIDTNTKTEQTLKEAKLAAKK PQEASGTKNSTDQAKNKASFKPETGQASGILEIPKINAELPIVEGTDADDLEKGVGHY KDSYYPDENGQIVLSGHRDTVFRRTGELEKGDQLRLLLSYGEFTYEIVKTKIVDKDDT SIITLQHEKEELILTTCYPFSYVGNAPKRYIIYGKRVT*" /label="srtA CDS" gene 919223..919819 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /label="srtA gene" downshifts 919798 /Source="Nicolas_upshifts" /id="D475" /incds=0 /nref=142 /ntot=248 /MaxReadThrough="0.9984" /MaxDrop="5.92245" /score="-4.06268332" /energy="-8.8" /TU="NA" /idTUdmin="U719" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(919849..920757) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /EC_number="5.4.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9814761, 15044829; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA pseudouridine synthase" /protein_id="NP_388802.2" /db_xref="EnsemblGenomes-Gn:BSU09210" /db_xref="EnsemblGenomes-Tr:CAB12749" /db_xref="GOA:P54604" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11598" /db_xref="UniProtKB/Swiss-Prot:P54604" /translation="MNQKGRGLEILINEKQDGQWLFSVLKTALKASKPVIQDWMSHQQ IKVNHESVLNNMIVKKGDRVFIDLQESEASSVIPEYGELDILFEDNHMLIINKPAGIA THPNEDGQTGTLANLIAYHYQINGETCKVRHVHRLDQDTSGAIVFAKHRLAHAILDQQ LEKKTLKRTYTAIAEGKLRTKKGTINSPIGRDRSHPTRRRVSPGGQTAVTHFKVMASN AKERLSLVELELETGRTHQIRVHLASLGHPLTGDSLYGGGSKLLNRQALHANKVQAVH PITDELIVAEAPFPADMKNLCRTYFS*" /label="yhcT CDS" gene complement(919849..920757) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /label="yhcT gene" promotor_-35 920813..920821 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(920814..920825) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(920820) /Source="Nicolas_upshifts" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(920822..921308) /Source="Nicolas_S_feature" /locus_tag="new_996597_997083_c" /HighExp="S8, dia15, Diami, H2O2, G180, G150, dia5, Paraq, Oxctl, S7" /AntisenseName="yhcU" /AntisenseCor="0.69394173601478304" /AntisenseRegPval="-39.200000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S319" upshifts 920832 /Source="Nicolas_upshifts" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 920835..920854 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(920839..920845) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 920868..921263 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388803.2" /db_xref="EnsemblGenomes-Gn:BSU09220" /db_xref="EnsemblGenomes-Tr:CAB12750" /db_xref="InterPro:IPR020355" /db_xref="SubtiList:BG11599" /db_xref="UniProtKB/Swiss-Prot:P54605" /translation="MARKVIDVRIVNAATAEQESFIKELSMELIHDVFPLYFSELDIQ RFKKKGVLSLNNHYYQGTLKEAFQIMACLQMIHIILTKPSPHSDLSDQAIFEKNSKML NDFGIYFPFAFSDFQKKTNKAFFGQRRLI*" /label="yhcU CDS" gene 920868..921263 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /label="yhcU gene" misc_feature complement(921294..921313) /Source="Nicolas_upshift_promotors" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(921308) /Source="Nicolas_upshifts" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 921348..921354 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 921363 /Source="Nicolas_upshifts" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 921368..921379 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(921378..921392) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(921392) /Source="Nicolas_upshifts" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(921400..921404) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 921400..921822 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CBS containing enzyme (sporulation-/ germination-related)" /protein_id="NP_388804.1" /db_xref="EnsemblGenomes-Gn:BSU09230" /db_xref="EnsemblGenomes-Tr:CAB12751" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG11600" /db_xref="UniProtKB/Swiss-Prot:P54606" /translation="MSSVKDTMTTQVATVSPNQTIQEAASLMKQHNVGAIPVVEQGVL KGMLTDRDIALRTTAQGRDGQTPVSEVMSTELVSGNPNMSLEDASQLMAQHQIRRLPI VDQNNLVGIVALGDLAVNQMSNESAGSALTNISHQNIH*" /label="yhcV CDS" gene 921400..921822 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /label="yhcV gene" promotor_no_box complement(921726..921826) /Source="Nicolas_upshift_promotors" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(921766) /Source="Nicolas_upshifts" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 921800 /Source="Nicolas_upshifts" /id="D476" /incds=0 /nref=50 /ntot=61 /MaxReadThrough="2.62549" /MaxDrop="7.03747" /score="-2.59023198" /energy="-12.1" /TU="NA" /idTUdmin="U723" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(921832) /Source="Nicolas_upshifts" /id="D477" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="0.0992700000000006" /MaxDrop="3.96142" /score="-9.32793172" /energy="-9.1" /TU="NA" /idTUdmin="U724" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" promotor_-35 921872..921879 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 921893..921912 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 921901 /Source="Nicolas_upshifts" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="upshifts" CDS 921949..922611 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /EC_number="3.1.3.18" /EC_number="3.1.3.68" /EC_number="3.1.3.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16990279, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphoglycolate phosphatase / glycerol-3-phosphate phosphatase / 2-deoxyglucose-6-phosphatase" /protein_id="NP_388805.1" /db_xref="EnsemblGenomes-Gn:BSU09240" /db_xref="EnsemblGenomes-Tr:CAB12752" /db_xref="GOA:P54607" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11601" /db_xref="UniProtKB/Swiss-Prot:P54607" /translation="MIKALIFDFDGLILDTETHEYEVLQEIFEEHGSVLPLSVWGKVI GTAAGFRPFEYLEEQIGKKLNHEELTQLRRERFAKRMESEKARPGVEAYLNAAKDLGL KIGLASSSDYKWVSGHLKQIGLFDDFEVIQTADDVEEVKPNPELYLLAAKNLGVSPAE CLAFEDSVNGSIAAKRAGMKCVIVPNKVTGTLMFEDYDHRLESMAEMELALLLDHLNS QN*" /label="glpW CDS" gene 921949..922611 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /label="glpW gene" CDS 922627..924168 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /EC_number="3.5.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26337367, 26808445, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388806.2" /db_xref="EnsemblGenomes-Gn:BSU09250" /db_xref="EnsemblGenomes-Tr:CAB12753" /db_xref="GOA:P54608" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR001110" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG11602" /db_xref="UniProtKB/Swiss-Prot:P54608" /translation="MSEKLDLTRFEKKMVIRNIEEKDIDKIIDLQKDCFPGMEPWKRE HLISHLEHFPEGQFCAEFEGEIIGSCSSLLINFDEYDDRHTWQDITDDGYITNHNPDG LNMYGIEVMVHPKYRRMKIGHRLYEARKDLARRLNLKSIIIGGRIPNYHKYAEEMTAR EYVEQVTRHQIYDPVLSFQLMNGFTLMRINPNYLPDDTASIKYATLMEWNNVDYLPQQ TKRYYKSAFPVRICVIQYEMKKIYSFEEFANQVEYYVDVASDARSDFAVFPEIFTTQL MSFLEERSPSLAVQRITEYTEDYISLFTDLAVKYNVNIIGGSHFVEEEGKIYNIAYLF RRDGTIEKQYKLHITPNERKWWGISAGDQVRVFDTDCGKIAIQICYDIEFPELARIAA DKGAKIIFTPFCTEDRQGYLRVRYCSQARAVENQIYTVISGTVGNLPQTENMDIQYAQ SGIFAPSDFEFARDGIVGETNPNIEMVVIGDVDLEILRRQRQNGTVRQLKDRRRDIYH IQYKK*" /label="yhcX CDS" gene 922627..924168 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /label="yhcX gene" downshifts 924151 /Source="Nicolas_upshifts" /id="D478" /incds=0 /nref=57 /ntot=238 /MaxReadThrough="4.24486" /MaxDrop="5.06754" /score="24.7413026" /energy="-10.5" /TU="U726" /idTUdmin="U726" /TUdmin="-224" /isTUend="FALSE" /label="downshifts" CDS 924252..924443 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52585.1" /translation="MYSGCALWSFCIFAISYIIQKTARLHIAIAMAVQVVSSATFIST MLSIVTLPVLLWKLHPLSS*" /label="yhzG CDS" gene 924252..924443 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /pseudo /label="yhzG gene" promotor_-35 924474..924481 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-35" promotor_-10 924496..924515 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-10" S_feature 924507..924588 /Source="Nicolas_S_feature" /locus_tag="new_1000282_1000363" /HighExp="M40t90, M0t90, T0.30H, LBGstat, BC, Lbstat, M9-stat, Lbtran, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S320" upshifts 924507 /Source="Nicolas_upshifts" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="upshifts" CDS 924589..925941 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11082195, 23610425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminotransferase" /protein_id="NP_388807.2" /db_xref="EnsemblGenomes-Gn:BSU09260" /db_xref="EnsemblGenomes-Tr:CAB12754" /db_xref="GOA:P33189" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10184" /db_xref="UniProtKB/Swiss-Prot:P33189" /translation="MEMMGMENIQQNQGLKQKDEQFVWHAMKGAHQADSLIAQKAEGA WVTDTDGRRYLDAMSGLWCVNIGYGRKELAEAAYEQLKELPYYPLTQSHAPAIQLAEK LNEWLGGDYVIFFSNSGSEANETAFKIARQYHLQNGDHSRYKFISRYRAYHGNTLGAL SATGQAQRKYKYEPLSQGFLHAAPPDIYRNPDDADTLESANEIDRIMTWELSETIAGV IMEPIITGGGILMPPDGYMKKVEDICRRHGALLICDEVICGFGRTGEPFGFMHYGVKP DIITMAKGITSAYLPLSATAVKRDIFEAYQGEAPYDRFRHVNTFGGSPAACALALKNL QIMEDEQLIQRSRDLGAKLLGELQALREHPAVGDVRGKGLLIGIELVKDKLTKEPADA AKVNQVVAACKEKGLIIGKNGDTVAGYNNVIQLAPPFCLTEEDLSFIVKTVKESFQTI *" /label="yhxA CDS" gene 924589..925941 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /label="yhxA gene" CDS 925969..926547 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11929549, 23610425, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 23610425, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate responding transcriptionantiterminator" /protein_id="NP_388808.1" /db_xref="EnsemblGenomes-Gn:BSU09270" /db_xref="EnsemblGenomes-Tr:CAB12755" /db_xref="GOA:P30300" /db_xref="InterPro:IPR006699" /db_xref="InterPro:IPR035928" /db_xref="SubtiList:BG10185" /db_xref="UniProtKB/Swiss-Prot:P30300" /translation="MMSFHNQPILPAIRNMKQFDEFLNSSFSYGVILDIHLGQLKGVI KEAQKHGKNMMVHVDLIQGIKHDEYGAEFICQDIKPAGIISTRSNVIAKAKQKKIYAI QRLFLLDTSAMEKSMEFIGKHKPDFIEVLPGIVPSLIQEIKEKTGIPIFAGGFIRTEE DVEQALKAGAVAVTTSNTKLWKKYENFLTESD*" /label="glpP CDS" gene 925969..926547 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /label="glpP gene" promotor_-35 926542..926549 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 926564..926583 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 926575 /Source="Nicolas_upshifts" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="upshifts" downshifts 926590 /Source="Nicolas_upshifts" /id="D479" /incds=0 /nref=3 /ntot=39 /MaxReadThrough="8.20986" /MaxDrop="2.99328" /score="6.07464219" /energy="-10" /TU="U727,U728" /idTUdmin="U726" /TUdmin=2215 /isTUend="FALSE" /label="downshifts" S_feature 926635..926725 /Source="Nicolas_S_feature" /locus_tag="new_1002410_1002500" /HighExp="Diami, T0.30H, G150, Oxctl, Gly, Paraq, dia5, BC, B60, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S321" CDS 926726..927550 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycerol permease" /protein_id="NP_388809.1" /db_xref="EnsemblGenomes-Gn:BSU09280" /db_xref="EnsemblGenomes-Tr:CAB12756" /db_xref="GOA:P18156" /db_xref="InterPro:IPR000425" /db_xref="InterPro:IPR022357" /db_xref="InterPro:IPR023271" /db_xref="SubtiList:BG10186" /db_xref="UniProtKB/Swiss-Prot:P18156" /translation="MTAFWGEVIGTMLLIIFGAGVCAGVNLKKSLSFQSGWIVVVFGW GLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEVPVYIAAQMIGAIIGAVIIYL HYLPHWKSTDDPAAKLGVFSTGPSIPHTFANVLSEVIGTFVLVLGILAIGANQFTEGL NPLIVGFLIVAIGISLGGTTGYAINPARDLGPRIAHAFLPIPGKGSSNWKYAWVPVVG PILGGSFGGVFYNAAFKGHITSSFWIVSVILVVVLLGLYVYTKSHSAKTLSNSKYI*" /label="glpF CDS" gene 926726..927550 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /label="glpF gene" CDS 927569..929059 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /EC_number="2.7.1.30" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9972264, 10920256, 11929549, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol kinase (sn-glycerol-3-phosphate generating)" /protein_id="NP_388810.2" /db_xref="EnsemblGenomes-Gn:BSU09290" /db_xref="EnsemblGenomes-Tr:CAB12757" /db_xref="GOA:P18157" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005999" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10187" /db_xref="UniProtKB/Swiss-Prot:P18157" /translation="METYILSLDQGTTSSRAILFNKEGKIVHSAQKEFTQYFPHPGWV EHNANEIWGSVLAVIASVISESGISASQIAGIGITNQRETTVVWDKDTGSPVYNAIVW QSRQTSGICEELREKGYNDKFREKTGLLIDPYFSGTKVKWILDNVEGAREKAEKGELL FGTIDTWLIWKMSGGKAHVTDYSNASRTLMFNIYDLKWDDELLDILGVPKSMLPEVKP SSHVYAETVDYHFFGKNIPIAGAAGDQQSALFGQACFEEGMGKNTYGTGCFMLMNTGE KAIKSEHGLLTTIAWGIDGKVNYALEGSIFVAGSAIQWLRDGLRMFQDSSLSESYAEK VDSTDGVYVVPAFVGLGTPYWDSDVRGSVFGLTRGTTKEHFIRATLESLAYQTKDVLD AMEADSNISLKTLRVDGGAVKNNFLMQFQGDLLNVPVERPEINETTALGAAYLAGIAV GFWKDRSEIANQWNLDKRFEPELEEEKRNELYKGWQKAVKAAMAFK*" /label="glpK CDS" gene 927569..929059 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /label="glpK gene" promotor_-35 928370..928376 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 928391..928410 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-10" upshifts 928401 /Source="Nicolas_upshifts" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="upshifts" S_feature 929060..929148 /Source="Nicolas_S_feature" /locus_tag="new_1004835_1004923" /HighExp="Sw, Etha, Salt, G150, Gly, Diami, T0.30H, B60, BC, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S322" downshifts 929105 /Source="Nicolas_upshifts" /id="D480" /incds=0 /nref=34 /ntot=91 /MaxReadThrough="7.63856" /MaxDrop="5.2045" /score="21.1943866" /energy="-28.7" /TU="U728,U729" /idTUdmin="U727" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 929111..929211 /Source="Nicolas_upshift_promotors" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 929171 /Source="Nicolas_upshifts" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="upshifts" CDS 929200..930867 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /EC_number="1.1.3.21" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2127799, 8825777, 9595668, 10633102, 18946204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2127799, 8825777, 9595668, 10633102, 18946204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate oxidase (FAD-dependent)" /protein_id="NP_388811.2" /db_xref="EnsemblGenomes-Gn:BSU09300" /db_xref="EnsemblGenomes-Tr:CAB12758" /db_xref="GOA:P18158" /db_xref="InterPro:IPR000447" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR031656" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10188" /db_xref="UniProtKB/Swiss-Prot:P18158" /translation="MMNHQFSSLERDRMLTDMTKKTYDLFIIGGGITGAGTALDAASR GMKVALSEMQDFAAGTSSRSTKLVHGGLRYLKQFEVKMVAEVGKERAIVYENGPHVTT PEWMLLPFHKGGTFGSFTTSIGLRVYDFLAGVKKSERRSMLSAKETLQKEPLVKKDGL KGGGYYVEYRTDDARLTIEVMKEAVKFGAEPVNYSKVKELLYEKGKAVGVLIEDVLTK KEYKVYAKKIVNATGPWVDQLREKDHSKNGKHLQHTKGIHLVFDQSVFPLKQAVYFDT PDGRMVFAIPREGKTYVGTTDTVYKEALEHPRMTTEDRDYVIKSINYMFPELNITAND IESSWAGLRPLIHEEGKDPSEISRKDEIWTSDSGLITIAGGKLTGYRKMAEHIVDLVR DRLKEEGEKDFGPCKTKNMPISGGHVGGSKNLMSFVTAKTKEGIAAGLSEKDAKQLAI RYGSNVDRVFDRVEALKDEAAKRNIPVHILAEAEYSIEEEMTATPADFFVRRTGRLFF DINWVRTYKDAVIDFMSERFQWDEQAKNKHTENLNKLLHDAVVPLEQ*" /label="glpD CDS" gene 929200..930867 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /label="glpD gene" promotor_-35 930629..930634 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 930649..930667 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-10" upshifts 930658 /Source="Nicolas_upshifts" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="upshifts" promotor_-35 930712..930718 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 930733 /Source="Nicolas_upshifts" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 930734..930752 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 930835 /Source="Nicolas_upshifts" /id="D481" /incds=0 /nref=13 /ntot=60 /MaxReadThrough="6.57605" /MaxDrop="4.31183" /score="11.5542287" /energy="-11.4" /TU="U728,U729,U730,U731,U732" /idTUdmin="U729" /TUdmin="-118" /isTUend="FALSE" /label="downshifts" S_feature 930880..930953 /Source="Nicolas_S_feature" /locus_tag="new_1006655_1006728" /HighExp="G150, Etha, Oxctl, H2O2, Gly, Diami, Paraq, Salt, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF, Sig-, SigB, SigA" /TUshortPSig="1, 0.995, 0.155, 1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S323" promotor_-35 930935..930942 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 930955 /Source="Nicolas_upshifts" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 930956..930975 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 930999..932744 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /EC_number="5.4.2.2" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15640167, 17662947, 24097947, 26735940, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15640167, 17662947, 24097947, 26735940, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-phosphoglucomutase" /protein_id="NP_388812.2" /db_xref="EnsemblGenomes-Gn:BSU09310" /db_xref="EnsemblGenomes-Tr:CAB12759" /db_xref="GOA:P18159" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG10189" /db_xref="UniProtKB/Swiss-Prot:P18159" /translation="MTWRKSYERWKQTEHLDLELKERLIELEGDEQALEDCFYKDLEF GTGGMRGEIGAGTNRMNIYTVRKASAGFAAYISKQGEEAKKRGVVIAYDSRHKSPEFA MEAAKTLATQGIQTYVFDELRPTPELSFAVRQLNAYGGIVVTASHNPPEYNGYKVYGD DGGQLPPKEADIVIEQVNAIENELTITVDEENKLKEKGLIKIIGEDIDKVYTEKLTSI SVHPELSEEVDVKVVFTPLHGTANKPVRRGLEALGYKNVTVVKEQELPDSNFSTVTSP NPEEHAAFEYAIKLGEEQNADILIATDPDADRLGIAVKNDQGKYTVLTGNQTGALLLH YLLSEKKKQGILPDNGVVLKTIVTSEIGRAVASSFGLDTIDTLTGFKFIGEKIKEYEA SGQYTFQFGYEESYGYLIGDFARDKDAIQAALLAVEVCAFYKKQGMSLYEALINLFNE YGFYREGLKSLTLKGKQGAEQIEAILASFRQNPPQKMAGKQVVTAEDYAVSKRTLLTE SKEEAIDLPKSNVLKYFLEDGSWFCLRPSGTEPKVKFYFAVKGSSLEDSEKRLAVLSE DVMKTVDEIVESTAK*" /label="pgcA CDS" gene 930999..932744 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /label="pgcA gene" downshifts 932733 /Source="Nicolas_upshifts" /id="D482" /incds=0 /nref=227 /ntot=264 /MaxReadThrough="4.80136" /MaxDrop="5.89896" /score="26.7163878" /energy="-13" /TU="U732,U733" /idTUdmin="U728" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" S_feature 932778..932847 /Source="Nicolas_S_feature" /locus_tag="new_1008553_1008622" /HighExp="Etha, H2O2, B36, dia15, Paraq, G150, LoTm, S8, Oxctl, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S324" misc_feature 932849..932868 /Source="Nicolas_upshift_promotors" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 932849 /Source="Nicolas_upshifts" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" CDS 932893..934032 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YhcZ]" /protein_id="NP_388813.1" /db_xref="EnsemblGenomes-Gn:BSU09320" /db_xref="EnsemblGenomes-Tr:CAB12760" /db_xref="GOA:O07527" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13005" /db_xref="UniProtKB/Swiss-Prot:O07527" /translation="MSKTRMEKLKTLKTIAETLNQGHDIKATLDEVLKELLSLTNLQS GWIFLIEEDGSYTLAADAYLPPALSRKEKVLMCEGECYCLTKFNNGGLRKAANIMNCK RIESAENLHCFDTEGITHHATVPLEDGDRRFGLLNVAAAGKTMFDEEELHLLESVAFQ IGTAIQRMRLSEYQQKNALLMERNRLAQELHDSVNQMLFSVSLTAKAAKTLTKDENLQ QMIDFIQNLSQDALAEMKALIWQLRPGGLEKGLAEAIKSYGALIGLKIIFTQKGCPVL TDEQEHMLWRVVQEALNNCKKHAGTDTAYVSLTASLCHAELDIIDHGAGFRYEAHAGL PSLGIKGMKERAEKAGAKFWIESALGTGTKLSIRLPLKSRKGGAV*" /label="yhcY CDS" gene 932893..934032 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /label="yhcY gene" CDS 934029..934673 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YhcY]" /protein_id="NP_388814.1" /db_xref="EnsemblGenomes-Gn:BSU09330" /db_xref="EnsemblGenomes-Tr:CAB12761" /db_xref="GOA:O07528" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13006" /db_xref="UniProtKB/Swiss-Prot:O07528" /translation="MKIVIADDHHVVRKGLRFFFATQDDIEVVGEAATGLEALRVIEE TKPDLVLMDLSMPEMDGIQAIKKAIQQFPDTNIIVLTSYSDQEHVIPALQAGAKAYQL KDTEPEELVKTRQVHGGEYKLSTAIMPHVLTHMKNQHDPEKEKYYQLTRREKDVLTEI ANGKSNKEIAAALFISEKTVKTHVSNLLAKLEVADRTQAALFAVKYNLNGEISK*" /label="yhcZ CDS" gene 934029..934673 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /label="yhcZ gene" CDS 934670..935194 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /EC_number="1.7.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15184374, 16816187, 20639339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidoreductase, NAD(P)H-FMN and ferric iron reductase (azoreductase)" /protein_id="NP_388815.1" /db_xref="EnsemblGenomes-Gn:BSU09340" /db_xref="EnsemblGenomes-Tr:CAB12762" /db_xref="GOA:O07529" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1NNI" /db_xref="PDB:2GSW" /db_xref="PDB:3GFQ" /db_xref="PDB:3GFR" /db_xref="PDB:3GFS" /db_xref="SubtiList:BG13007" /db_xref="UniProtKB/Swiss-Prot:O07529" /translation="MNMLVINGTPRKHGRTRIAASYIAALYHTDLIDLSEFVLPVFNG EAEQSELLKVQELKQRVTKADAIVLLSPEYHSGMSGALKNALDFLSSEQFKYKPVALL AVAGGGKGGINALNNMRTVMRGVYANVIPKQLVLDPVHIDVENATVAENIKESIKELV EELSMFAKAGNPGV*" /label="azr CDS" gene 934670..935194 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /label="azr gene" downshifts 935159 /Source="Nicolas_upshifts" /id="D483" /incds=0 /nref=72 /ntot=215 /MaxReadThrough="2.90096" /MaxDrop="4.78561" /score="27.1269177" /energy="-17.2" /TU="NA" /idTUdmin="U734" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(935209..935451) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388816.1" /db_xref="EnsemblGenomes-Gn:BSU09350" /db_xref="EnsemblGenomes-Tr:CAB12763" /db_xref="InterPro:IPR025431" /db_xref="SubtiList:BG13008" /db_xref="UniProtKB/Swiss-Prot:O07530" /translation="MDYADYDKALYYTHRSQWDNLLILMVRTEDDLLSKRIEHFLHAY HFEQDYAVLEKMLYSLLRYIDHATELTYEDQIALLT*" /label="yhdB CDS" gene complement(935209..935451) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /label="yhdB gene" downshifts complement(935230) /Source="Nicolas_upshifts" /id="D484" /incds=0 /nref=39 /ntot=84 /MaxReadThrough="-0.0235599999999998" /MaxDrop="7.78706" /score="12.0066876" /energy="-17.2" /TU="NA" /idTUdmin="U735" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(935487..935498) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(935498) /Source="Nicolas_upshifts" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(935512..935519) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 935586..935592 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 935606..935617 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 935616 /Source="Nicolas_upshifts" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="upshifts" CDS 935652..935975 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388817.1" /db_xref="EnsemblGenomes-Gn:BSU09360" /db_xref="EnsemblGenomes-Tr:CAB12764" /db_xref="InterPro:IPR024987" /db_xref="SubtiList:BG13009" /db_xref="UniProtKB/Swiss-Prot:O07531" /translation="MKSLPYTIALLFCGLIIVSMAAKGHSTDTDESVQKWEQLAWSKI QDEYKGASFSDYAYMGRTEVNDQQTKDVFRVTVRQKDDTFSVRAEVYFHPVTNHMISI NVFRL*" /label="yhdC CDS" gene 935652..935975 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /label="yhdC gene" S_feature 935976..937842 /Source="Nicolas_S_feature" /locus_tag="new_1011751_1013617" /HighExp="S8, S5, S7, S6, S4, C30, Sw, ferm, S3, BC" /AntisenseName="lytF" /AntisenseCor="-0.65564579825076796" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S325" CDS complement(936017..937483) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10206711, 14594841, 18761694, 18761696, 23091053, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10206711, 14594841, 18761694, 18761696, 23091053, 25288647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamate-meso-diaminopimelate muropeptidase (major autolysin, vegetative)" /protein_id="NP_388818.2" /db_xref="EnsemblGenomes-Gn:BSU09370" /db_xref="EnsemblGenomes-Tr:CAB12776" /db_xref="GOA:O07532" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13010" /db_xref="UniProtKB/Swiss-Prot:O07532" /translation="MKKKLAAGLTASAIVGTTLVVTPAEAATIKVKSGDSLWKLAQTY NTSVAALTSANHLSTTVLSIGQTLTIPGSKSSTSSSTSSSTTKKSGSSVYTVKSGDSL WLIANEFKMTVQELKKLNGLSSDLIRAGQKLKVSGTVSSSSSSSKKSNSNKSSSSSSK SSSNKSSSSSSSTGTYKVQLGDSLWKIANKVNMSIAELKVLNNLKSDTIYVNQVLKTK SSGSDTSSKDNSSKSNQTSATTKYTVKSGDSLWKIANNYNLTVQQIRNINNLKSDVLY VGQVLKLTGKASSGSSSSSSSSSNASSGTTTTYTVKSGDSLWVIAQKFNVTAQQIREK NNLKTDVLQVGQKLVISGKASSSSSSGSSNTTSSTSAKINTMISAAKAQLGVPYRWGG TTPSGFDCSGFIYYVLNKVTSVSRLTAAGYWNTMKSVSQPAVGDFVFFSTYKAGPSHV GIYLGNGEFINANDSGVVISNMNNSYWKQRYLGAKRYF*" /label="lytF CDS" gene complement(936017..937483) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /label="lytF gene" downshifts complement(936029) /Source="Nicolas_upshifts" /id="D485" /incds=0 /nref=121 /ntot=216 /MaxReadThrough="2.34529" /MaxDrop="4.33563" /score="24.6732339" /energy="-14.2" /TU="NA" /idTUdmin="U737" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(936116) /Source="Nicolas_upshifts" /id="D486" /incds=1 /nref=1 /ntot=87 /MaxReadThrough="5.73069" /MaxDrop="2.6306" /score="24.6732339" /energy="-14.2" /TU="U737" /idTUdmin="U737" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(937523..937541) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(937535) /Source="Nicolas_upshifts" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(937555..937562) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(937636..938076) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033; Product type r: regulator" /codon_start=1 /transl_table=11 /product="NO-dependent activator of the ResDE regulon (Fe-S NO binding site)" /protein_id="NP_388819.1" /db_xref="EnsemblGenomes-Gn:BSU09380" /db_xref="EnsemblGenomes-Tr:CAB12777" /db_xref="GOA:O07573" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13011" /db_xref="UniProtKB/Swiss-Prot:O07573" /translation="MKLTNYTDYSLRVLIFLAAERPGELSNIKQIAETYSISKNHLMK VIYRLGQLGYVETIRGRGGGIRLGMDPEDINIGEVVRKTEDDFNIVECFDANKNLCVI SPVCGLKHVLNEALLAYLAVLDKYTLRDLVKNKEDIMKLLKMKE*" /label="nsrR CDS" gene complement(937636..938076) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /label="nsrR gene" downshifts complement(937666) /Source="Nicolas_upshifts" /id="D487" /incds=0 /nref=205 /ntot=265 /MaxReadThrough="3.11158" /MaxDrop="6.87147" /score="5.96186156" /energy="-7.8" /TU="U739" /idTUdmin="U740" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" promotor_-35 938064..938070 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 938084..938095 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 938086..938196 /Source="Nicolas_S_feature" /locus_tag="new_1013861_1013971" /HighExp="S8, S7, S4, Sw, S5, S6, BC, B60, nit, Pyr" /AntisenseName="ygxB" /AntisenseCor="-0.211236686077168" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.904" /TUlongSig="NA" /TUlongPSig="NA" /label="S326" upshifts 938086 /Source="Nicolas_upshifts" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(938098..938117) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(938114) /Source="Nicolas_upshifts" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(938129..938135) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 938155 /Source="Nicolas_upshifts" /id="D488" /incds=0 /nref=10 /ntot=68 /MaxReadThrough="1.05981" /MaxDrop="6.25571" /score="22.5171081" /energy="-11.6" /TU="NA" /idTUdmin="U738" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(938183..939841) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388820.1" /db_xref="EnsemblGenomes-Gn:BSU09390" /db_xref="EnsemblGenomes-Tr:CAB12778" /db_xref="GOA:P37874" /db_xref="InterPro:IPR008910" /db_xref="SubtiList:BG10181" /db_xref="UniProtKB/Swiss-Prot:P37874" /translation="MYEPARQKMIVSLGQEKIPPAHSSVCLLDKWVNTHHTTKKERYQ LNVADVFSSYLSKLPNVIIALLVLLIGWAIAKIIEKAVYKGLSKTKIDDKLFAGKKPS RYSSEKVISKVVYFIALIIVFILFFNILHLTTVASPFVSMLSAIAAAIPSVLKAGLIL LLGWAAASVLSFLVKKIGMKLNTSDKLRKWNLVSEGKDIHQAVNTASQIVFYLVLLVF LPGVLSSLKISGISGPFTNMMESVLAFLPKLFAAALIVLIGWLVARLVRDIITNFLAS IGTERFAARMGLSIYLKDTSLSAVIGTIAYVLIMIPVVISALDQLDVAGISKPAVSML NTILNMLPNIMIAIVLVLAGIWAGKWVKSMVSGLLHRAGFDSVLGKMGMEAGTPAKLS LSQVVGMIAQIIVILLFTAEALQIVRLHFLVEIATGIIAYLPNVLVAVFILGLGLYAG ELVRKVLASMIKGQEFKSLAPIAKYTIIALAFFMALDQLGVAATIVNSAFIIVLSGFA LAFGLSFGLGGKDFASRYLSTFERKMQNTEIEKNRKNQNPPNDM*" /label="ygxB CDS" gene complement(938183..939841) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /label="ygxB gene" downshifts complement(938188) /Source="Nicolas_upshifts" /id="D489" /incds=0 /nref=6 /ntot=40 /MaxReadThrough="8.34865" /MaxDrop="5.55332" /score="-5.46969987" /energy="-14.5" /TU="U740" /idTUdmin="U740" /TUdmin="-532" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(939732..939750) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(939752) /Source="Nicolas_upshifts" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(939764..939770) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 939813..939818 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 939834..939852 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 939847 /Source="Nicolas_upshifts" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="upshifts" CDS 939872..941278 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8144469, 14680823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8144469, 14680823; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation, conserved in non sporulating bacteria" /protein_id="NP_388821.1" /db_xref="EnsemblGenomes-Gn:BSU09400" /db_xref="EnsemblGenomes-Tr:CAB12779" /db_xref="GOA:P37875" /db_xref="InterPro:IPR007390" /db_xref="SubtiList:BG10182" /db_xref="UniProtKB/Swiss-Prot:P37875" /translation="MNAEEKKGLQRAIEEITEIAKGFGLDFYPMRYEICPAEIIYTFG AYGMPTRFSHWSFGKQFHKMKLHYDLGLSKIYELVINSDPCYAFLLDSNSLIQNKLIV AHVLAHCDFFKNNCRFQNTKRDMVESMAATAERIKHYEQVHGIKEVESFLDAILSIQE HIDPSLVRPKLQWSVDDEEEEIEEAATPYDDLWSLDEKKPKKQVKKSKKPFPPRPEKD ILLFIEEHSRELEPWQRDILTMMREEMLYFWPQLETKIMNEGWASYWHQRIIRELDLT SDEAIEFAKLNAGVVQPSKTGINPYYLGLKIFEDIEKRYNNPTEEMKKMGVQPDSGRE KMFEVREIESDISFIRNYLTKELVMREDLYLFQKQGRDYKIIDKQWKSVRDQLVSMRV NGGFPYLTVNDGDYMKNNELYIKHWYEGIELDLKYLEKVLPYLFQLWGRSVHIESVLE DKEVMFSYDGKGVHRRYL*" /label="spoVR CDS" gene 939872..941278 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /label="spoVR gene" downshifts 941258 /Source="Nicolas_upshifts" /id="D490" /incds=0 /nref=43 /ntot=84 /MaxReadThrough="1.30719" /MaxDrop="6.74388" /score="26.4488835" /energy="-11.5" /TU="NA" /idTUdmin="U741" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(941308..942693) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /EC_number="3.1.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8830275, 10913081, 12897025, 16491025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830275, 10913081, 12897025, 16491025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline phosphatase A" /protein_id="NP_388822.2" /db_xref="EnsemblGenomes-Gn:BSU09410" /db_xref="EnsemblGenomes-Tr:CAB12780" /db_xref="GOA:P19406" /db_xref="InterPro:IPR001952" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR018299" /db_xref="SubtiList:BG10183" /db_xref="UniProtKB/Swiss-Prot:P19406" /translation="MKKMSLFQNMKSKLLPIAAVSVLTAGIFAGAELQQTEKASAKKQ DKAEIRNVIVMIGDGMGTPYIRAYRSMKNNGDTPNNPKLTEFDRNLTGMMMTHPDDPD YNITDSAAAGTALATGVKTYNNAIGVDKNGKKVKSVLEEAKQQGKSTGLVATSEINHA TPAAYGAHNESRKNMDQIANSYMDDKIKGKHKIDVLLGGGKSYFNRKDRNLTKEFKQA GYSYVTTKQALKKNKDQQVLGLFADGGLAKALDRDSKTPSLKDMTVSAIDRLNQNKKG FFLMVEGSQIDWAAHDNDTVGAMSEVKDFEQAYKAAIEFAKKDKHTLVIATADHTTGG FTIGANGEKNWHAEPILSAKKTPEFMAKKISEGKPVKDVLARYANLKVTSEEIKSVEA AAQADKSKGASKAIIKIFNTRSNSGWTSTDHTGEEVPVYAYGPGKEKFRGLINNTDQA NIIFKILKTGK*" /label="phoA CDS" gene complement(941308..942693) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /label="phoA gene" downshifts complement(941334) /Source="Nicolas_upshifts" /id="D491" /incds=0 /nref=51 /ntot=178 /MaxReadThrough="1.90638" /MaxDrop="5.795" /score="22.2126775" /energy="-13.2" /TU="NA" /idTUdmin="U742" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(942720) /Source="Nicolas_upshifts" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(942722..944253) /Source="Nicolas_S_feature" /locus_tag="new_1018497_1020028_c" /HighExp="Etha, Salt, B60, Heat, M9-stat, T5.0H, T0.30H, T4.0H, T3.30H, T2.30H" /AntisenseName="lytE" /AntisenseCor="-0.65081062481616203" /AntisenseRegPval="-33.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="0.966, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S327" misc_feature complement(942730..942741) /Source="Nicolas_upshift_promotors" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 942849..942856 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 942869..942888 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 942875..943162 /Source="Nicolas_S_feature" /locus_tag="new_1018650_1018937" /HighExp="T-5.40H, Cold, LoTm, T-4.40H, UNK1, T5.0H, GM-0.1, T3.30H, S1, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S328" upshifts 942875 /Source="Nicolas_upshifts" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 943125..943128 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 943143..943162 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 943164 /Source="Nicolas_upshifts" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="upshifts" CDS 943223..944227 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 16950129, 9457885, 21541672, 22139507, 27002131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 16950129, 9457885, 21541672, 22139507, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cell wall dl-endopeptidase; phosphatase-associated protein (major autolysin)" /protein_id="NP_388823.2" /db_xref="EnsemblGenomes-Gn:BSU09420" /db_xref="EnsemblGenomes-Tr:CAB12781" /db_xref="GOA:P54421" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11406" /db_xref="UniProtKB/Swiss-Prot:P54421" /translation="MKKQIITATTAVVLGSTLFAGAASAQSIKVKKGDTLWDLSRKYD TTISKIKSENHLRSDIIYVGQTLSINGKSTSSKSSSSSSSSSTYKVKSGDSLWKISKK YGMTINELKKLNGLKSDLLRVGQVLKLKGSTSSSSSSSSKVSSSSTSTYKVKSGDSLS KIASKYGTTVSKLKSLNGLKSDVIYVNQVLKVKGTSTSSSKPASSSSSSSSKTSSTSL NVSKLVSDAKALVGTPYKWGGTTTSGFDCSGFIWYVLNKQTSVGRTSTAGYWSSMKSI ASPSVGDFVFFTTYKSGPSHMGIYIGNNSFIHAGSDGVQISSLNNSYWKPRYLGAKRF *" /label="lytE CDS" gene 943223..944227 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /label="lytE gene" downshifts 944089 /Source="Nicolas_upshifts" /id="D492" /incds=1 /nref=1 /ntot=117 /MaxReadThrough="6.89938" /MaxDrop="2.1687" /score="26.3320532" /energy="-9.8" /TU="U743,U744" /idTUdmin="U743" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 944219 /Source="Nicolas_upshifts" /id="D493" /incds=0 /nref=53 /ntot=190 /MaxReadThrough="3.64545" /MaxDrop="6.08377" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" upshifts complement(944253) /Source="Nicolas_upshifts" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(944260..944275) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 944265 /Source="Nicolas_upshifts" /id="D494" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="2.99" /MaxDrop="3.76174" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 complement(944287..944296) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(944298..945173) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8045899, 10869065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045899, 10869065; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator CitR (LysR family)" /protein_id="NP_388824.2" /db_xref="EnsemblGenomes-Gn:BSU09430" /db_xref="EnsemblGenomes-Tr:CAB12782" /db_xref="GOA:P39127" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10853" /db_xref="UniProtKB/Swiss-Prot:P39127" /translation="MDFKWLHTFVTAAKYENFRKTAETLFLSQPTVTVHIKQLEKEIS CKLFERKGRQIQLTDEGRAYLPYALRLLDDYENSMAELHRVRQGYSQTLQLAVSPLIA DTVLPSVMKRYTAMNTETEMAVTIFESAEIASLIKAGEADIGLSCLKVQSSSLSCHCL YKDPVVLVAPPDKRFIEDNEIDAKEVLEQYLLLTHNHPDYWDDLLRQVRMTFPFVRTM KVTQTHITKRFIKEGLGVSFLPLSTVKRELAEKQMIRIPYQSVQLPYAGAYAIALYEN KKEKKFLDFLSHFHF*" /label="citR CDS" gene complement(944298..945173) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /label="citR gene" promotor_-35 945226..945227 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(945239..945258) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-10" promotor_-10 945244..945263 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(945245) /Source="Nicolas_upshifts" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="upshifts" upshifts 945254 /Source="Nicolas_upshifts" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(945273..945278) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-35" CDS 945282..946382 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:4211224, 8045898, 8045899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4211224, 8045898, 8045899; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase I" /protein_id="NP_388825.2" /db_xref="EnsemblGenomes-Gn:BSU09440" /db_xref="EnsemblGenomes-Tr:CAB12783" /db_xref="GOA:P39119" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR016143" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="PDB:2C6X" /db_xref="SubtiList:BG10854" /db_xref="UniProtKB/Swiss-Prot:P39119" /translation="MVHYGLKGITCVETSISHIDGEKGRLIYRGHHAKDIALNHSFEE AAYLILFGKLPSTEELQVFKDKLAAERNLPEHIERLIQSLPNNMDDMSVLRTVVSALG ENTYTFHPKTEEAIRLIAITPSIIAYRKRWTRGEQAIAPSSQYGHVENYYYMLTGEQP SEAKKKALETYMILATEHGMNASTFSARVTLSTESDLVSAVTAALGTMKGPLHGGAPS AVTKMLEDIGEKEHAEAYLKEKLEKGERLMGFGHRVYKTKDPRAEALRQKAEEVAGND RDLDLALHVEAEAIRLLEIYKPGRKLYTNVEFYAAAVMRAIDFDDELFTPTFSASRMV GWCAHVLEQAENNMIFRPSAQYTGAIPEEVLS*" /label="citA CDS" gene 945282..946382 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /label="citA gene" promotor_-35 946393..946399 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 946414..946432 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 946419 /Source="Nicolas_upshifts" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="upshifts" CDS 946456..947325 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 18643936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)-dependent dehydrogenase" /protein_id="NP_388826.1" /db_xref="EnsemblGenomes-Gn:BSU09450" /db_xref="EnsemblGenomes-Tr:CAB12784" /db_xref="GOA:O07575" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13012" /db_xref="UniProtKB/Swiss-Prot:O07575" /translation="MNPMDRQTEGQEPQHQDRQPGIESKMNPLPLSEDEDYRGSGKLK GKVAIITGGDSGIGRAAAIAFAKEGADISILYLDEHSDAEETRKRIEKENVRCLLIPG DVGDENHCEQAVQQTVDHFGKLDILVNNAAEQHPQDSILNISTEQLEKTFRTNIFSMF HMTKKALPHLQEGCAIINTTSITAYEGDTALIDYSSTKGAIVSFTRSMAKSLADKGIR VNAVAPGPIWTPLIPATFPEEKVKQHGLDTPMGRPGQPVEHAGAYVLLASDESSYMTG QTIHVNGGRFIST*" /label="yhdF CDS" gene 946456..947325 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /label="yhdF gene" downshifts 947333 /Source="Nicolas_upshifts" /id="D495" /incds=0 /nref=27 /ntot=130 /MaxReadThrough="8.65426" /MaxDrop="6.48064" /score="18.1511963" /energy="-8.2" /TU="U748" /idTUdmin="U747" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 947410..947413 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 947425 /Source="Nicolas_upshifts" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 947428..947447 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 947473..947492 /Source="Nicolas_upshift_promotors" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 947478..947574 /Source="Nicolas_S_feature" /locus_tag="new_1023253_1023349" /HighExp="Etha, T2.30H, T-0.40H, T2.0H, T1.30H, S1, GM-0.2, T3.0H, T-1.40H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.27332800000000002" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.522, 0.998, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S329" upshifts 947478 /Source="Nicolas_upshifts" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="upshifts" CDS 947575..948972 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16621821, 16850406, 21097623, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16621821, 16850406, 21097623, 25645558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid transporter or methylthioribose-degradation metabolite exporter" /protein_id="NP_388827.1" /db_xref="EnsemblGenomes-Gn:BSU09460" /db_xref="EnsemblGenomes-Tr:CAB12785" /db_xref="GOA:O07576" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004758" /db_xref="SubtiList:BG13013" /db_xref="UniProtKB/Swiss-Prot:O07576" /translation="MKGSVFRKKSIQDLIAATSGEKSLKRELGAFDLTLLGIGAIIGT GIFVLTGTGAVTAGPGLTISFVVAALACLFAALSYAEFASSVPVSGSVYTFTYATLGE LMAFIIGWDLILEYMLAVSAVSVGWSGYFQSFLSGLGIHLPVALTAAPGAVKGTFTLF NLPAFVIVMAITYLLYLGIKESKRVNNIMVILKILVVLLFIAVAAVYVKPHNWQPFMP MGFGGVFSAAALVFFAFIGFDAVSSAAEETKNPAKDLPKGIIFSLLVCTILYVTVSAI MTGVIPFAQFAGVDHPVSLVLQSAGQNWVAGIIDIGAVLGMTTVMLVMLYGQTRVMFA MSRDGLVPGSLSKVHPKHKTPYVATWFFGTMSALLGSLVPLDELAKLVNIGTLSAFVL ISVAVIVLRKKQPDLPRAFKCPGVPVIPGLAILFCLFLILNLGWVTIVRFLVWLLIGL VIYFLYSRKHSKLNQ*" /label="bcaP CDS" gene 947575..948972 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /label="bcaP gene" downshifts 948952 /Source="Nicolas_upshifts" /id="D496" /incds=0 /nref=116 /ntot=188 /MaxReadThrough="3.41176" /MaxDrop="5.29633" /score="5.08283681" /energy="-12.3" /TU="U748,U749" /idTUdmin="U750" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 949033..949037 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 949053..949072 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 949060 /Source="Nicolas_upshifts" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="upshifts" CDS 949090..950445 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_388828.1" /db_xref="EnsemblGenomes-Gn:BSU09470" /db_xref="EnsemblGenomes-Tr:CAB12786" /db_xref="GOA:O07577" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13014" /db_xref="UniProtKB/Swiss-Prot:O07577" /translation="MSEQKPVQWASKIGFVMAAAGSAIGLGAIWKFPYVAGTNGGGAF FLIFVLFTILLGYPLLVGEFIFGRRNQTNAIDAYKKEAPRSAWFLTGWIGVAACFLVL SFYSVIGGWILLYIVKTASGSLSGLSQAQYGALFASIIQNPVQTLAAQLVFMALTVLV VARGVQKGIERVSAVMMPILFLLFILLVLRSLTLNGAMEGVKFLLVPHFGDLTPESIL FALGQAFFTLTLGVSVMVTYSSYLPKTQNIPRSAASIVLMNIIVTLLAGLAIFPAVFS FGFQPNEGPTLLFTVLPAVFEQLPFGTLFFIGFLVAFLFAALTSAFSMVEIIVATIGK GDEKKRKKLSWTSGLLIFLVGIPCCLSYGVLSDVHLFGKTFFDIADFTVSNVLMPSGA LLISLFIPLKISKSELLAEMRNGSNAGKAFFYTWFYLLRFIVPLAIIIVFLNLIGILS F*" /label="yhdH CDS" gene 949090..950445 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /label="yhdH gene" downshifts 950426 /Source="Nicolas_upshifts" /id="D497" /incds=0 /nref=184 /ntot=244 /MaxReadThrough="1.73756" /MaxDrop="6.09379" /score="40.1809389" /energy="-14.8" /TU="NA" /idTUdmin="U751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(950480..951889) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388829.1" /db_xref="EnsemblGenomes-Gn:BSU09480" /db_xref="EnsemblGenomes-Tr:CAB12787" /db_xref="GOA:O07578" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13015" /db_xref="UniProtKB/Swiss-Prot:O07578" /translation="MDITPFLDKKSKTPLYEQLYTFFKQEISHARITKGTRLPSKRRL SSLLDVSTATIERAYEQLTAEGYVKSKPKIGWFAAEVEPGFPTAPDHFQQSVQPGLHQ KNAPAIDFHQGSVDPTLFPFNAWRKSIVKSLDRYSGSFHTSGDPQGEYELRHMIARFV RLSRGVNCEPGQIIIGAGTTVLLQNLCLSLKPGTKIGFEEPGFHRSRRMFEANHMDVT PICSDAEGVLPDELYRQNPYLMYTTPSHQFPIGTIMTITRRQELLAWAAETNSFIIED DYDGEFRYSGHPIPSLQGLDPNGRVIYLGTFSKSLLPSLRLSFMIVPPELMEPIQNNV QLMKQTVSAHSQLALADFIETGEWQKHINRMRSLYRKKHAVLLEAIRSELGNTVEILG KNSGLHILLRLLFPASEEEAIQAAADHGVTLYPVSPSYIEQTPFTSVLIGYGGLSEED IRLGIQKLKTAWAPLISSY*" /label="yhdI CDS" gene complement(950480..951889) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /label="yhdI gene" promotor_-35 951938..951941 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 951956..951975 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 951958 /Source="Nicolas_upshifts" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(951960..951979) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(951972) /Source="Nicolas_upshifts" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(951995..951999) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 951999..952427 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388830.1" /db_xref="EnsemblGenomes-Gn:BSU09490" /db_xref="EnsemblGenomes-Tr:CAB12788" /db_xref="GOA:O07579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13016" /db_xref="UniProtKB/Swiss-Prot:O07579" /translation="MIHMKQLTSKEEWAESYPIMSELRTELDIETYLQRLEACVQKES YMLFALYENTAIRALCGALPRVSIHKGEHLWIADLVTTAPCRSKGYGKMLLDYASDWA RKAGLGFVSLSSGLQRKDAHRFYTDKMGFTIESYLFRKPV*" /label="yhdJ CDS" gene 951999..952427 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /label="yhdJ gene" downshifts 952406 /Source="Nicolas_upshifts" /id="D498" /incds=0 /nref=46 /ntot=213 /MaxReadThrough="1.42962" /MaxDrop="4.77191" /score="24.6412105" /energy="-12.1" /TU="NA" /idTUdmin="U752" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(952458..952748) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388831.1" /db_xref="EnsemblGenomes-Gn:BSU09500" /db_xref="EnsemblGenomes-Tr:CAB12789" /db_xref="GOA:O07580" /db_xref="InterPro:IPR020496" /db_xref="SubtiList:BG13017" /db_xref="UniProtKB/Swiss-Prot:O07580" /translation="MELVRIFKEHNVFGWISVGTAVLSLLLLNLAIISNVTFYSYQML PFAMAAVPFGVVELFIKRGRTGPGLLGVILNLFVIICVYTIVSVDTNLQFGF*" /label="asiMB CDS" gene complement(952458..952748) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /label="asiMB gene" downshifts complement(952482) /Source="Nicolas_upshifts" /id="D499" /incds=0 /nref=44 /ntot=229 /MaxReadThrough="2.66153" /MaxDrop="4.72865" /score="26.7359231" /energy="-11.1" /TU="NA" /idTUdmin="U754" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(952736..953812) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388832.1" /db_xref="EnsemblGenomes-Gn:BSU09510" /db_xref="EnsemblGenomes-Tr:CAB12790" /db_xref="GOA:O07581" /db_xref="InterPro:IPR025672" /db_xref="InterPro:IPR029101" /db_xref="SubtiList:BG13018" /db_xref="UniProtKB/Swiss-Prot:O07581" /translation="MMNEEFKKRFDQYKNGEMSDQEMTAFEEELEKLEVYQELIDSEL EDDNDWDLSISPEKQKAILAYGKRKSYLRISVLAVISTLMILPLCTLGSYLYYGMGGK HSTGNEFMETAAVTVALTMPNVLVDTSGLKSQVKLFGMNTEFPLQKQIGTKTAAVGNE RVEMFYNKVKAPAVNYYDLEVNKTGHYFTHPSNKSEQTTAKAEKTLSTLPEGTVSEVY LSYDRAYPTKDVYNKFKGYDVSFLWNAIETEKNTNKTASTEPLGYPGKDSKFLAALNT KGKSNGDQFINALKFMSKHEKWAQVISKRKDLNVDNRLDYVEKNGVNVYGSVVTGPTK EIQRMLKNKSVKSANVGEVELWNW*" /label="asiMA CDS" gene complement(952736..953812) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /label="asiMA gene" CDS complement(953802..954293) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14651641, 14769884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14651641, 14769884; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma(M))" /protein_id="NP_388833.1" /db_xref="EnsemblGenomes-Gn:BSU09520" /db_xref="EnsemblGenomes-Tr:CAB12791" /db_xref="GOA:O07582" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13019" /db_xref="UniProtKB/Swiss-Prot:O07582" /translation="MTIDEIYQMYMNDVYRFLLSMTKDKHLAEDLLQETFMRAYIHIH SYDHSKVKPWLFQVARNAFIDYVRKHKKEVTISDDLIGSLFQNAVQSPAHQVEIKEVL TGYMSELPDNYREALTLYYLKELNYKEASHIMNISEANFKSVLFRARQRLKALYNRGV NDE*" /label="sigM CDS" gene complement(953802..954293) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /label="sigM gene" S_feature complement(954294..954396) /Source="Nicolas_S_feature" /locus_tag="new_1030069_1030171_c" /HighExp="Cold, LBGstat, H2O2, G180, Paraq, Oxctl, G135, HPh, dia15, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S330" promotor_-10 complement(954385..954404) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(954396) /Source="Nicolas_upshifts" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(954418..954421) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 954434..954440 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 954451 /Source="Nicolas_upshifts" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 954455..954473 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(954484) /Source="Nicolas_upshifts" /id="D500" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="2.13683" /MaxDrop="4.59517" /score="8.96845329" /energy="-10.2" /TU="NA" /idTUdmin="U757" /TUdmin=1804 /isTUend="FALSE" /label="downshifts" CDS 954490..955485 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10220166, 15019785, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15019785, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldo/keto reductase specific for NADPH; protectsagainst methylglyoxal" /protein_id="NP_388834.1" /db_xref="EnsemblGenomes-Gn:BSU09530" /db_xref="EnsemblGenomes-Tr:CAB12792" /db_xref="GOA:P80874" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PZ1" /db_xref="SubtiList:BG13020" /db_xref="UniProtKB/Swiss-Prot:P80874" /translation="MEYTSIADTGIEASRIGLGTWAIGGTMWGGTDEKTSIETIRAAL DQGITLIDTAPAYGFGQSEEIVGKAIKEYGKRDQVILATKTALDWKNNQLFRHANRAR IVEEVENSLKRLQTDYIDLYQVHWPDPLVPIEETAEVMKELYDAGKIRAIGVSNFSIE QMDTFRAVAPLHTIQPPYNLFEREMEESVLPYAKDNKITTLLYGSLCRGLLTGKMTEE YTFEGDDLRNHDPKFQKPRFKEYLSAVNQLDKLAKTRYGKSVIHLAVRWILDQPGADI ALWGARKPGQLEALSEITGWTLNSEDQKDINTILENTISDPVGPEFMAPPTREEI*" /label="akrN CDS" gene 954490..955485 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /label="akrN gene" downshifts 955464 /Source="Nicolas_upshifts" /id="D501" /incds=0 /nref=59 /ntot=160 /MaxReadThrough="6.85446" /MaxDrop="4.90106" /score="10.4379759" /energy="-11.8" /TU="U755" /idTUdmin="U756" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 955547..955550 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 955565..955584 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 955570 /Source="Nicolas_upshifts" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="upshifts" CDS 955620..956219 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /EC_number="2.3.1.51" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1557036, 17557823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1557036, 17557823; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-acylglycerol-phosphate (1-acyl-G3P) acyltransferase" /protein_id="NP_388835.1" /db_xref="EnsemblGenomes-Gn:BSU09540" /db_xref="EnsemblGenomes-Tr:CAB12793" /db_xref="GOA:O07584" /db_xref="InterPro:IPR002123" /db_xref="InterPro:IPR004552" /db_xref="SubtiList:BG13021" /db_xref="UniProtKB/Swiss-Prot:O07584" /translation="MYKFCANALKVILSLRGGVKVYNKENLPADSGFVIACTHSGWVD VITLGVGILPYQIHYMAKKELFQNKWIGSFLKKIHAFPVDRENPGPSSIKTPIKLLKE GEIVGIFPSGTRTSEDVPLKRGAVTIAQMGKAPLVPAAYQGPSSGKELFKKGKMKLII GEPLHQADFAHLPSKERLAAMTEALNQRIKELENKLDQL*" /label="plsC CDS" gene 955620..956219 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /label="plsC gene" downshifts 956234 /Source="Nicolas_upshifts" /id="D502" /incds=0 /nref=189 /ntot=245 /MaxReadThrough="6.36101" /MaxDrop="7.07164" /score="-7.3088084" /energy="-6.1" /TU="U755" /idTUdmin="U756" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 956279..958233 /Source="Nicolas_S_feature" /locus_tag="new_1032054_1034008" /HighExp="Cold, C30, S8, T-4.40H, Sw, Fru, S0, S7, HPh, G135" /AntisenseName="yhdP" /AntisenseCor="-0.46228251493795502" /AntisenseRegPval="-14.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S331" CDS complement(956288..957622) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /function="16.1: Circulate" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 25182490; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative magnesium efflux pump" /protein_id="NP_388836.1" /db_xref="EnsemblGenomes-Gn:BSU09550" /db_xref="EnsemblGenomes-Tr:CAB12794" /db_xref="GOA:O07585" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13022" /db_xref="UniProtKB/Swiss-Prot:O07585" /translation="MDIVNLILVAVLIALTAFFVASEFAIIRIRGSRIDQLIAEGNKA AIAVKKVTTHLDEYLSACQLGITLTSIGLGVLGESTIERLLHPLFVQMNVPGSLSHVI SFIFAYAIITFLHVVVGELAPKTVAIQKAEAVSMLFAKPLIWFYRIAFPFIWLLNNSA RLLTKAFGLETVSENELAHSEEELRIILSESYKSGEINQSEFKYVNKIFEFDDRLAKE IMIPRTEIVSLPHDIKISEMMDIIQIEKYTRYPVEEGDKDNIIGVINIKEVLTACISG EVSVDSTISQFVNPIIHVIESAPIQDLLVKMQKERVHMAILSDEYGGTAGLVTVEDII EEIVGEIRDEFDIDEISEIRKIGEGHYILDGKVLIDQVNDLLGIHLENEEVDTIGGWF LTQKYDVEKDDSIIEEGCEFIINEIDGHHVAYIEVKKLQEEELLETANQQEA*" /label="yhdP CDS" gene complement(956288..957622) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /label="yhdP gene" downshifts complement(956307) /Source="Nicolas_upshifts" /id="D503" /incds=0 /nref=284 /ntot=315 /MaxReadThrough="1.96991" /MaxDrop="7.22379" /score="11.1466394" /energy="-9.1" /TU="NA" /idTUdmin="U757" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" CDS complement(957683..958114) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 18048925" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 18048925; Product type r: regulator" /codon_start=1 /transl_table=11 /product="indirect copper efflux transcriptional regulator" /protein_id="NP_388837.1" /db_xref="EnsemblGenomes-Gn:BSU09560" /db_xref="EnsemblGenomes-Tr:CAB12795" /db_xref="GOA:O07586" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13023" /db_xref="UniProtKB/Swiss-Prot:O07586" /translation="MVGRDIDGAETYRISELAALAGVTKRTVDYYTNLGLLTPARSCS NYRYYDENALKRLIFIVDCKKQRLALSDIKDRLENQFPSSAKLDDEIGNLALEIDHMN QNISGILHRFERLKPEDRDKLKSKLPPEKLAVFQSFMLLLS*" /label="cueR CDS" gene complement(957683..958114) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /label="cueR gene" promotor_-10 complement(958126..958145) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(958136) /Source="Nicolas_upshifts" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(958160..958166) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(958162..958262) /Source="Nicolas_upshift_promotors" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 958197..958204 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-35" upshifts complement(958202) /Source="Nicolas_upshifts" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 958218..958237 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-10" upshifts 958235 /Source="Nicolas_upshifts" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="upshifts" CDS 958271..959452 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965, 15103638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_388838.1" /db_xref="EnsemblGenomes-Gn:BSU09570" /db_xref="EnsemblGenomes-Tr:CAB12796" /db_xref="GOA:O07587" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13024" /db_xref="UniProtKB/Swiss-Prot:O07587" /translation="MKLAGLSREVEENLNKGSWIRKLFDEGARLKKEFGEDQVFDFSL GNPIVEPPEAFKRALIEEAEKGSHGYIQNQGLLAAREKVAQFLGSRFEADFSAERIVM TVGAGGALNVALKSIVNPGEEVIILAPYFAEYKLYIENYGGKAVSCPLTSRFEIDIEA VRQSITPQTKGLILNTPHNPTGTVLSQKNIDDLGALLKEIEEKSGQTIYVLFDEPYSQ LIYDEELANPFQSYHRVILASSFSKDLGIAGERLGYIGLDSRMPDADLLINAFVYCNR TLGFVNAPVMMQRAVARMDDLRVDASAYKERRDLMVDILKEAGFEFEMPKGGFFVFPK SPIEDEVAFCVHAAQKYKLLIVPSSGFGMSGHFRLSFSVPIEQIKNSRDIFISLYKDF A*" /label="yhdR CDS" gene 958271..959452 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /label="yhdR gene" downshifts 959437 /Source="Nicolas_upshifts" /id="D504" /incds=0 /nref=12 /ntot=180 /MaxReadThrough="2.81766" /MaxDrop="3.37889" /score="-5.8634451" /energy="-9.1" /TU="U759" /idTUdmin="U759" /TUdmin="-163" /isTUend="FALSE" /label="downshifts" S_feature 959482..959620 /Source="Nicolas_S_feature" /locus_tag="new_1035257_1035395" /HighExp="Etha, S1, BMM, S2, Cold, MG 45, MG 25, C90, T-5.40H, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S332" misc_feature 959616..959635 /Source="Nicolas_upshift_promotors" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 959622..959778 /Source="Nicolas_S_feature" /locus_tag="new_1035397_1035553" /HighExp="M9-stat, B60, T4.0H, T3.0H, LoTm, S5, T5.0H, S4, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S333" upshifts 959622 /Source="Nicolas_upshifts" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="upshifts" CDS 959779..961164 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388840.1" /db_xref="EnsemblGenomes-Gn:BSU09590" /db_xref="EnsemblGenomes-Tr:CAB12798" /db_xref="GOA:O07589" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13026" /db_xref="UniProtKB/Swiss-Prot:O07589" /translation="MDDIDSLILIGVLIALTAFFVASEFAIVRVRRSRIDQLITEGNK RAILARRVITDLDEYLSASQLGITLTSIGLGVLGEPAFERLLHPLFEPLGLPDSVSHA VSFAVAYGLITFLHVVVGELAPKTVAIQKAEQLTLLIAGPLRLFYLLLFPFIWILNGS ARLLCGMFGLKPASEHDGSHSEEELRMLLSESLKNGEINPSEYKYVNKIFEFDNRIAK EIMIPRKEMAAVSTEMTMAEMLEVMLKEKYTRWPVTDGDKDSVLGLVNTKHLFSDLLF MTEEERMKMTIHPYVRPVIEVIETIPVHDLLIKMQRERIHMAILSDEYGGTSGLVTTE DILEEIVGEIRDEFDEDEQPLIQKLGDGHYVMDGKVRIDQVNSLLGASIQEDVDTIGG LILKENIDIEAGESIRIGSYTIKVLKMDGRLIKQIDIKEEAGNTTGITAHHKLPLPEP VMLNSATLSEK*" /label="yhdT CDS" gene 959779..961164 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /label="yhdT gene" downshifts 961054 /Source="Nicolas_upshifts" /id="D505" /incds=1 /nref=120 /ntot=240 /MaxReadThrough="5.11037" /MaxDrop="3.79021" /score="19.6985636" /energy="-10.5" /TU="U760" /idTUdmin="U760" /TUdmin="-86" /isTUend="FALSE" /label="downshifts" downshifts 961140 /Source="Nicolas_upshifts" /id="D506" /incds=0 /nref=129 /ntot=245 /MaxReadThrough="1.68999" /MaxDrop="6.12682" /score="19.6985636" /energy="-10.5" /TU="NA" /idTUdmin="U760" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(961178..961534) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 17196979, 22194412, 27824896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fluoride efflux channel component A" /protein_id="NP_388841.1" /db_xref="EnsemblGenomes-Gn:BSU09600" /db_xref="EnsemblGenomes-Tr:CAB12799" /db_xref="GOA:O07590" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13027" /db_xref="UniProtKB/Swiss-Prot:O07590" /translation="MTLAGIFIGGGLGAMLRFWLGNVITAKTKGLSLPIGILTVNILG ALGLGIFTGLHVANASVSLIIGTGFFGAFTTFSTFSVETIQLLMAKRVKESILYIVLT LCGSLFAFWCGWTITI*" /label="crcBA CDS" gene complement(961178..961534) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /label="crcBA gene" CDS complement(961531..961926) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /function="16.1: Circulate" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 22194412, 27824896; Product type t : transporter" /codon_start=1 /transl_table=11 /product="subunit of fluoride efflux transporter" /protein_id="NP_388842.1" /db_xref="EnsemblGenomes-Gn:BSU09610" /db_xref="EnsemblGenomes-Tr:CAB12800" /db_xref="GOA:O07591" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13028" /db_xref="UniProtKB/Swiss-Prot:O07591" /translation="MKIYSAVFIGGALGACLRYGLNLWIHTGQFPAATWLENAAGSLL LGILTGFFMIGAKRPLLSAFLGTGFCGGFTTMSTFSKETVMLLQGQPSLALLYVAASL ISGIIFALIGVFVGRRIAGIQQRKGLQEK*" /label="crcBB CDS" gene complement(961531..961926) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /label="crcBB gene" CDS complement(961913..962644) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /EC_number="3.1.4.46" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8012593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycerophosphodiester phosphodiesterase" /protein_id="NP_388843.1" /db_xref="EnsemblGenomes-Gn:BSU09620" /db_xref="EnsemblGenomes-Tr:CAB12801" /db_xref="GOA:O07592" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG13029" /db_xref="UniProtKB/Swiss-Prot:O07592" /translation="MYIIAHRGASGYAPENTIAAFDLAVKMNADMIELDVQLTKDRQI VVIHDDRVDRTTNGSGFVKDFTLEELQKLDAGSWYGPAFQGERIPTLEAVLKRYHKKI GLLIELKGHPSQVGIEEEVGQLLGQFSFSINNIVQSFQFRSVQRFRELYPSIPTAVIT RPNFGMLSRNQMKAFRSFANYVNIKHTRLNRLMIGSINKNGLNIFAWTVNNQKTAAKL QAMGVDGIVTDYPDFIIKDGKHENI*" /label="yhdW CDS" gene complement(961913..962644) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /label="yhdW gene" misc_feature complement(962669..962688) /Source="Nicolas_upshift_promotors" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(962690) /Source="Nicolas_upshifts" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 962737..962745 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 962754 /Source="Nicolas_upshifts" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 962759..962774 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 962768..962841 /Source="Nicolas_S_feature" /locus_tag="new_1038543_1038616" /HighExp="S5, S4, S6, S7, S8, S3, B60, Pyr, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.563" /TUlongSig="NA" /TUlongPSig="NA" /label="S334" promotor_-35 962828..962829 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 962843 /Source="Nicolas_upshifts" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 962845..962864 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-10" CDS 962878..962985 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388844.1" /db_xref="EnsemblGenomes-Gn:BSU09630" /db_xref="EnsemblGenomes-Tr:CAB12802" /db_xref="InterPro:IPR035384" /db_xref="SubtiList:BG13030" /db_xref="UniProtKB/Swiss-Prot:O07593" /translation="MGKGRIRVEERIKAETDAEMQKATLLDQTQTKKGK*" /label="yhdX CDS" gene 962878..962985 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /label="yhdX gene" S_feature 962986..963039 /Source="Nicolas_S_feature" /locus_tag="new_1038761_1038814" /HighExp="Sw, BC, LPhT, HiOs, S4, HiTm, S5, B36, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S335" downshifts 963010 /Source="Nicolas_upshifts" /id="D507" /incds=0 /nref=177 /ntot=225 /MaxReadThrough="0.97838" /MaxDrop="7.47175" /score="21.9742676" /energy="-14.5" /TU="NA" /idTUdmin="U762" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 963090..963109 /Source="Nicolas_upshift_promotors" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 963096 /Source="Nicolas_upshifts" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="upshifts" CDS 963134..964249 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /function="16.8: Protect" /function="16.12: Sense" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12077558, 15849754, 16850406, 17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12077558, 15849754, 16850406, 17665170, 18310427, 19252899; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small conductance mechano-sensitive channel" /protein_id="NP_388845.1" /db_xref="EnsemblGenomes-Gn:BSU09640" /db_xref="EnsemblGenomes-Tr:CAB12803" /db_xref="GOA:O07594" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR006686" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13031" /db_xref="UniProtKB/Swiss-Prot:O07594" /translation="MPDYLQQYFTLDNIIQIGISLAILLVFLILRKLFTRYFFNLLFN LTNRPKTEIFKQVVLAFDKPARWFFVALGLFLAIRYSPFLDEQMPVISKIYRSLIVAL LCWGLCNLTATSSFIFHKVNQRFELDMDDILAPFLSKLLRFVIIALSVSVIAQEFNYD VNGFVAGLGLGGLAFALAAKDTISNFFGGIIIITEKPFTIGDWVETSTVTGSVEDITF RSTRFRTAQGALVTVPNSTLSMEAITNWTRMTKRQITFSIHVSYATPIENLERSIHSL RTMLLEHEGVDNEIIMVNFDTFADSYYNLFFNFYTKTTVWAENLNIREDINYKIIEIL GAEGVQFAYPGQMVVVKQKHESDQFQVNLNKEEKERA*" /label="mscY CDS" gene 963134..964249 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /label="mscY gene" downshifts 964229 /Source="Nicolas_upshifts" /id="D508" /incds=0 /nref=5 /ntot=141 /MaxReadThrough="3.45709" /MaxDrop="3.93891" /score="2.31392404" /energy="-12.3" /TU="U764" /idTUdmin="U764" /TUdmin="-783" /isTUend="FALSE" /label="downshifts" misc_feature 964286..964305 /Source="Nicolas_upshift_promotors" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 964286 /Source="Nicolas_upshifts" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="upshifts" CDS 964319..965062 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16768447, 19136592, 26708127, 27987242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16768447, 19136592, 26708127, 27987242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirtuin NAD-dependent deacetylase" /protein_id="NP_388846.1" /db_xref="EnsemblGenomes-Gn:BSU09650" /db_xref="EnsemblGenomes-Tr:CAB12804" /db_xref="GOA:O07595" /db_xref="InterPro:IPR003000" /db_xref="InterPro:IPR026590" /db_xref="InterPro:IPR028628" /db_xref="InterPro:IPR029035" /db_xref="SubtiList:BG13032" /db_xref="UniProtKB/Swiss-Prot:O07595" /translation="METFKSILHEAQRIVVLTGAGMSTESGIPDFRSAGGIWTEDASR MEAMSLDYFLSYPRLFWPKFKELFQMKMSGSFEPNEGHLLLAELEKQGKQVDIFTQNI DGLHKKAGSRHVYELHGSIQTAACPACGARYDLPHLLEREVPECTAAGNNGDICGTVL KTDVVLFGDAVMHFDTLYEKLDQADLLLVIGTSLEVAPARFVPEDASLIPGMKKVIIN LEPTYCDSLFDMVIHQKIGEFARSLGMKK*" /label="srtN CDS" gene 964319..965062 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /label="srtN gene" downshifts 965034 /Source="Nicolas_upshifts" /id="D509" /incds=0 /nref=3 /ntot=82 /MaxReadThrough="1.93149" /MaxDrop="2.85561" /score="9.76884826" /energy="-9.2" /TU="NA" /idTUdmin="U765" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(965086..965934) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polysaccharide deacetylase" /protein_id="NP_388847.1" /db_xref="EnsemblGenomes-Gn:BSU09660" /db_xref="EnsemblGenomes-Tr:CAB12805" /db_xref="GOA:O07596" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG13046" /db_xref="UniProtKB/Swiss-Prot:O07596" /translation="MRQTRGEASPSAVSLAFKFASLAVLCVLLLLMVILGYSNSSTKA KEVTVTTNGQLRDEKESLKLKNDSPDLLIKHLQTKQNMGDKTVYLTFDDGPSAVTTRL LDVLKSADVKATFFMLSPRMNEFKQAVKRAEKEGHALGLHGVTHNNRLFYQTPTSPLK EMQEARDTLQDITGYKTDLVRTPYGSKPSLTASQIRNLEKDGFVYWDWTIDSMDWKYR NSQYVTAVLQQLENMEHSSSSRPNVILMHDLPATVNALPVLINKLKEKGYSFGVLEDT MVPVHE*" /label="yheN CDS" gene complement(965086..965934) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /label="yheN gene" downshifts complement(965110) /Source="Nicolas_upshifts" /id="D510" /incds=0 /nref=126 /ntot=242 /MaxReadThrough="2.03966" /MaxDrop="4.72968" /score="-7.82934513" /energy="-9.2" /TU="NA" /idTUdmin="U767" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 965930..965935 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(965935..966034) /Source="Nicolas_S_feature" /locus_tag="new_1041710_1041809_c" /HighExp="Cold, T3.0H, T2.30H, T3.30H, T4.0H, T2.0H, HPh, C30, T1.30H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S336" promotor_-10 965951..965969 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 965953 /Source="Nicolas_upshifts" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="upshifts" S_feature 965958..966153 /Source="Nicolas_S_feature" /locus_tag="new_1041733_1041928" /HighExp="S5, S4, S6, S3, S7, S8, LoTm, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S337" promotor_-10 complement(966023..966042) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(966037) /Source="Nicolas_upshifts" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(966057..966060) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 966152..966171 /Source="Nicolas_upshift_promotors" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 966155..966218 /Source="Nicolas_S_feature" /locus_tag="new_1041930_1041993" /HighExp="BC, T2.30H, T3.0H, T3.30H, T4.0H, T5.0H, T2.0H, T1.30H, S4, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S338" upshifts 966155 /Source="Nicolas_upshifts" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="upshifts" CDS 966219..967067 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /EC_number="2.6.1.21" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9003455, 17005988; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine aminotransferase" /protein_id="NP_388848.1" /db_xref="EnsemblGenomes-Gn:BSU09670" /db_xref="EnsemblGenomes-Tr:CAB12806" /db_xref="GOA:O07597" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005784" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG13045" /db_xref="UniProtKB/Swiss-Prot:O07597" /translation="MKVLVNGRLIGRSEASIDLEDRGYQFGDGIYEVIRVYKGVLFGL REHAERFFRSAAEIGISLPFSIEDLEWDLQKLVQENAVSEGAVYIQTTRGVAPRKHQY EAGLEPQTTAYTFTVKKPEQEQAYGVAAITDEDLRWLRCDIKSLNLLYNVMTKQRAYE AGAFEAILLRDGVVTEGTSSNVYAVINGTVRTHPANRLILNGITRMNILGLIEKNGIK LDETPVSEEELKQAEEIFISSTTAEIIPVVTLDGQSIGSGKPGPVTKQLQAAFQESIQ QAASIS*" /label="dat CDS" gene 966219..967067 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /label="dat gene" downshifts 967058 /Source="Nicolas_upshifts" /id="D511" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="2.27201" /MaxDrop="6.88888" /score="21.6239924" /energy="-11.5" /TU="U768" /idTUdmin="U766" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(967110..968471) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735849, 11274110, 15849754, 16850406, 17937670" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735849, 11274110, 15849754, 16850406, 17937670; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_388849.1" /db_xref="EnsemblGenomes-Gn:BSU09680" /db_xref="EnsemblGenomes-Tr:CAB12807" /db_xref="GOA:O07553" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG13044" /db_xref="UniProtKB/Swiss-Prot:O07553" /translation="MDSQKKLTFPLAVGLFIFMLCIIISCLFLLHVEPHIPLFLSVVM LSAAALWFGFPWKSIEKGIVDGIKNGVQPIIVLALIGILIGAWMYSGAIPTMTVYALS FIEPSHLLLTALFSCMIISTLVGSSLTTVSTIGVALIGVASAAGVPLEWTAGAVICGA CFGDKMSPMSDTTNFAAGIGEIPIFEHIRHMMGTTIPALLITVVLFYFLGSSVSADAA STDNIQQVITGIKDAANVTPWALLSPLLVVLLAMKRVSVIPVLTAGIISSGILTAIFV PYSSLQAFMTALQNGTTFETDNEAAAKIINRGGLQSMMGSVSLIMIAFALGGLMEKIG LISALLEGVMKGIRSKGRLVAATVCSSIGVNLATGEQYLSILIPGQSFKSLYDKRNIQ RKFLTRSLEDGGTLINPLIPWGVSGAFMASALGVPVIDYIPFTFFLYISPMISILIGF VKK*" /label="nhaC CDS" gene complement(967110..968471) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /label="nhaC gene" downshifts complement(967134) /Source="Nicolas_upshifts" /id="D512" /incds=0 /nref=7 /ntot=77 /MaxReadThrough="0.50034" /MaxDrop="3.60175" /score="1.04025421" /energy="-11.5" /TU="NA" /idTUdmin="U769" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(968472..968542) /Source="Nicolas_S_feature" /locus_tag="new_1044247_1044317_c" /HighExp="B60, G135, Etha, LBGexp, G150, Diami, Paraq, G180, H2O2, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S339" misc_feature complement(968515..968534) /Source="Nicolas_upshift_promotors" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(968542) /Source="Nicolas_upshifts" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(968598..969098) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /function="16.12: Sense" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 16159758, 27464829; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein, UspA family" /protein_id="NP_388850.2" /db_xref="EnsemblGenomes-Gn:BSU09690" /db_xref="EnsemblGenomes-Tr:CAB12808" /db_xref="GOA:O07552" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13043" /db_xref="UniProtKB/Swiss-Prot:O07552" /translation="MFHADRIIVAFDGSENSKKALLTAIDLAKTVNAAITVAHSHDMK DNQTVIDPPRPAAEASYISGGMTSVPDPLISDVTSPEPMIYEDRTEEVIAEARMMLNE QQADGDIDILEGDPAESIIEHANRISADMIVTGSRDQNRLKKLIFGSVSEKLSAKSDI PVLIVK*" /label="nhaX CDS" gene complement(968598..969098) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /label="nhaX gene" downshifts complement(968630) /Source="Nicolas_upshifts" /id="D513" /incds=0 /nref=10 /ntot=63 /MaxReadThrough="4.74071" /MaxDrop="5.69273" /score="4.44189378" /energy="-12.2" /TU="U770" /idTUdmin="U770" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(969120..969138) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(969140) /Source="Nicolas_upshifts" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(969153..969159) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 969177..969184 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 969192..969261 /Source="Nicolas_S_feature" /locus_tag="new_1044967_1045036" /HighExp="C90, M9-stat, BC, T1.30H, T3.30H, Sw, T5.0H, GM 15, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S340" upshifts 969193 /Source="Nicolas_upshifts" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 969199..969218 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 969262..969423 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /experiment="publication(s) with functional evidences, PMID:25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25217586; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator leader peptide" /protein_id="NP_388851.1" /db_xref="EnsemblGenomes-Gn:BSU09700" /db_xref="EnsemblGenomes-Tr:CAB12809" /db_xref="SubtiList:BG13042" /db_xref="UniProtKB/Swiss-Prot:O07551" /translation="MFIKQFHIGAANLLFCFRERFFRSDRALKSAVRNISVKKGMELT LHAFFIYKI*" /label="bmrB CDS" gene 969262..969423 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /label="bmrB gene" downshifts 969353 /Source="Nicolas_upshifts" /id="D514" /incds=1 /nref=29 /ntot=180 /MaxReadThrough="5.31538" /MaxDrop="4.59672" /score="25.6910195" /energy="-14.4" /TU="U771" /idTUdmin="U768" /TUdmin=2273 /isTUend="FALSE" /label="downshifts" S_feature 969424..969542 /Source="Nicolas_S_feature" /locus_tag="new_1045199_1045317" /HighExp="LPhT, S7, S6, T-1.10H, Sw, LBGstat, S5, T-0.40H, S8, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S341" CDS 969543..971300 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388852.1" /db_xref="EnsemblGenomes-Gn:BSU09710" /db_xref="EnsemblGenomes-Tr:CAB12810" /db_xref="GOA:O07550" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13041" /db_xref="UniProtKB/Swiss-Prot:O07550" /translation="MFSVLKKLGWFFKAYWLRYTIAIVLLLAVNVIEMFPPKLLGNAI DDMKAGAFTAEGLLFYIGIFFVLTAAVYIMSYFWMHQLFGGANLMEKILRTKLMGHLL TMSPPFYEKNRTGDLMARGTNDLQAVSLTTGFGILTLVDSTMFMMTIFLTMGFLISWK LTFAAIIPLPVMAIAISLYGSKIHERFTEAQNAFGALNDRVLESVSGVRVIRAYVQET NDVRRFNEMTADVYQKNMKVAFIDSLFEPTVKLLVGASYLIGLGYGAFLVFRNELTLG ELVSFNVYLGMMIWPMFAIGELINVMQRGNASLDRVNETLSYETDVTDPKQPADLKEP GDIVFSHVSFTYPSSTSDNLQDISFTVRKGQTVGIAGKTGSGKTTIIKQLLRQYPPGE GSITFSGVPIQQIPLDRLRGWIGYVPQDHLLFSRTVKENILYGKQDATDKEVQQAIAE AHFEKDLHMLPSGLETMVGEKGVALSGGQKQRISIARALMANPEILILDDSLSAVDAK TEAAIIKNIRENRKGKTTFILTHRLSAVEHADLILVMDGGVIAERGTHQELLANNGWY REQYERQQLFTAEEGGAGA*" /label="bmrC CDS" gene 969543..971300 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /label="bmrC gene" CDS 971297..973318 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding subunit)" /protein_id="NP_388853.1" /db_xref="EnsemblGenomes-Gn:BSU09720" /db_xref="EnsemblGenomes-Tr:CAB12811" /db_xref="GOA:O07549" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13040" /db_xref="UniProtKB/Swiss-Prot:O07549" /translation="MKIGKTLWRYALLYRKLLITAVLLLTVAVGAELTGPFIGKKMID DHILGIEKTWYEAAEKDKNAVQFHGVSYVREDRLQEPVSKAKEAHIYQVGMAFYFVDQ AVSFDGNRTVSDGKLTITNGDKSRAYAAEKLTKQELFQFYQPEIKGMVLLICLYGGLL VFSVFFQYGQHYLLQMSANRIIQKMRQDVFSHIQKMPIRYFDNLPAGKVVARITNDTE AIRDLYVTVLSTFVTSGIYMFGIFTALFLLDVKLAFVCLAIVPIIWLWSVIYRRYASY YNQKIRSINSDINAKMNESIQGMTIIQAFRHQKETMREFEELNESHFYFQNRMLNLNS LMSHNLVNVIRNLAFVCLIWHFGGASLNAAGIVSIGVLYAFVDYLNRLFQPITGIVNQ FSKLELARVSAGRVFELLEEKNTEEAGEPAKERALGRVEFRDVSFAYQEGEEVLKHIS FTAQKGETVALVGHTGSGKSSILNLLFRFYDAQKGDVLIDGKSIYNMSRQELRSHMGI VLQDPYLFSGTIGSNVSLDDERMTEEEIKNALRQVGAEPLLKKLPKGINEPVIEKGST LSSGERQLISFARALAFDPAILILDEATAHIDTETEAVIQKALDVVKQGRTTFVIAHR LSTIRNADQILVLDKGEIVERGNHEELMALEGQYYQMYELQKGQKHSIA*" /label="bmrD CDS" gene 971297..973318 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /label="bmrD gene" downshifts 973306 /Source="Nicolas_upshifts" /id="D515" /incds=0 /nref=69 /ntot=230 /MaxReadThrough="0.741399999999999" /MaxDrop="5.11492" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U771" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(973367..973987) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-flavin oxidoreductase" /protein_id="NP_388854.1" /db_xref="EnsemblGenomes-Gn:BSU09730" /db_xref="EnsemblGenomes-Tr:CAB12812" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13039" /db_xref="UniProtKB/Swiss-Prot:O07548" /translation="MKIALLGASGRVGQAFLTQAAADERFDIFALIRSQHADLPLSKD RTVMGNARRLEDVKKIMENAEIVISCLGTDGDDTLSTAMAHILSVMEEQHIKRLITIG TAGILDSRYEPGKYRFETNESKRKQTRAAKEHAKVYEMLKESSLDWTIICPTYLPDGT ATGVYRTERNVLPEGGTSISVGDTADFLYRELVTGEYVGNRVGLAY*" /label="yheG CDS" gene complement(973367..973987) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /label="yheG gene" downshifts complement(973382) /Source="Nicolas_upshifts" /id="D516" /incds=0 /nref=19 /ntot=169 /MaxReadThrough="1.82652" /MaxDrop="3.00293" /score="-0.293143554" /energy="-10.9" /TU="NA" /idTUdmin="U772" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 973972..974072 /Source="Nicolas_upshift_promotors" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(974001..974020) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(974016) /Source="Nicolas_upshifts" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="upshifts" CDS complement(974026..974151) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388855.1" /db_xref="EnsemblGenomes-Gn:BSU09740" /db_xref="EnsemblGenomes-Tr:CAB12813" /db_xref="SubtiList:BG13038" /db_xref="UniProtKB/Swiss-Prot:O07547" /translation="MSFITIVNWELVQFVSVSMIHEYVSHRSVYLYRYSFPRCSN*" /label="yheF CDS" gene complement(974026..974151) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /label="yheF gene" upshifts 974032 /Source="Nicolas_upshifts" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(974035..974038) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(974165..974184) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(974174) /Source="Nicolas_upshifts" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(974198..974207) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 974230 /Source="Nicolas_upshifts" /id="D517" /incds=0 /nref=6 /ntot=22 /MaxReadThrough="0.352760000000001" /MaxDrop="4.67633" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U773" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(974256..974459) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:3009398, 9572981, 16707666, 19659696, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009398, 9572981, 16707666, 19659696, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (beta-type SASP)" /protein_id="NP_388856.1" /db_xref="EnsemblGenomes-Gn:BSU09750" /db_xref="EnsemblGenomes-Tr:CAB12814" /db_xref="GOA:P04832" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10787" /db_xref="UniProtKB/Swiss-Prot:P04832" /translation="MANQNSSNDLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRANG SVGGEITKRLVSFAQQQMGGRVQ*" /label="sspB CDS" gene complement(974256..974459) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /label="sspB gene" downshifts complement(974261) /Source="Nicolas_upshifts" /id="D518" /incds=0 /nref=72 /ntot=93 /MaxReadThrough="1.27819" /MaxDrop="8.55895" /score="22.2113888" /energy="-16" /TU="NA" /idTUdmin="U776" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(974460..974570) /Source="Nicolas_S_feature" /locus_tag="new_1050235_1050345_c" /HighExp="S8, S5, S7, S6, S4, G/S, Pyr, ferm, BT, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S342" promotor_no_box 974500..974600 /Source="Nicolas_upshift_promotors" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 974560 /Source="Nicolas_upshifts" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(974576) /Source="Nicolas_upshifts" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(974580..974591) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(974606..974612) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(974668..974886) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation / germination island)" /protein_id="NP_388857.1" /db_xref="EnsemblGenomes-Gn:BSU09760" /db_xref="EnsemblGenomes-Tr:CAB12815" /db_xref="InterPro:IPR017263" /db_xref="SubtiList:BG13037" /db_xref="UniProtKB/Swiss-Prot:O07546" /translation="MAVMISHFSWKPLFPKEKLPGWKISFYYKGTHYEGIYHKSGEIE WGDLFPARADEPALTNEIHELMLFHIYD*" /label="yheE CDS" gene complement(974668..974886) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /label="yheE gene" downshifts complement(974702) /Source="Nicolas_upshifts" /id="D519" /incds=0 /nref=5 /ntot=83 /MaxReadThrough="0.43384" /MaxDrop="3.42951" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U777" /TUdmin=110 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(974927..974946) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(974944) /Source="Nicolas_upshifts" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(974960..974967) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(975036..976397) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /function="16.5: Explore" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15231775, 25035995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 25035995; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat associated protein" /protein_id="NP_388858.2" /db_xref="EnsemblGenomes-Gn:BSU09770" /db_xref="EnsemblGenomes-Tr:CAB12816" /db_xref="GOA:O07545" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13036" /db_xref="UniProtKB/Swiss-Prot:O07545" /translation="MNPKRFLIGIDKTSENTLFLPSSLKQDGLLHAAFGTKVVRCHVA YRRHLEQTVLLSENLFHELLLPHRSRADILIHDHTVHIGPLVGIFTAGFTVSLERPFK DRSLFFSKLVTLHEQAGGYCFVFGAHQINWEEGTIEGLLYRENGWEKKIVPLPNVVYD RLPNRKIEDSLLLQHTKKRLIDEYQIPWFNKTFFNKWNVHQLLEKDPRTAPFLPRSEL TPSVELIDELCGAYKKVYIKPANGALGTGIYQLTRTDGGLTVKHTNDAKTFTSIDYSD AASFLAEFQKHHNPSDFLIQQGVDLIEFQGKPADFRVHTNKNRKGKWTVTAIAVKISG KNSITTHLSNGGTVKTLAEVYDDPAERVEVIKKLSAAALTASHVLHDHIEGFIGEIGF DFGIDQNGKVWMFEANSRPGRSIFSHPNLHHVDSLTKRRSFEYASYLSEKAITSPEAL WPS*" /label="spaD CDS" gene complement(975036..976397) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /label="spaD gene" downshifts complement(975054) /Source="Nicolas_upshifts" /id="D520" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.33323" /MaxDrop="3.7968" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U779" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(975098) /Source="Nicolas_upshifts" /id="D521" /incds=1 /nref=2 /ntot=45 /MaxReadThrough="5.29177" /MaxDrop="3.36501" /score="37.4339943" /energy="-11.8" /TU="U779" /idTUdmin="U779" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(976387..977478) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231775, 25035995; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat associated protein, subunit C" /protein_id="NP_388859.1" /db_xref="EnsemblGenomes-Gn:BSU09780" /db_xref="EnsemblGenomes-Tr:CAB12817" /db_xref="GOA:O07544" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13035" /db_xref="UniProtKB/Swiss-Prot:O07544" /translation="MITLGFMSLSRQHEADYSAELAKRAPEFGIRFIRFTPFDISPDT LRVKASVYHSASSTWNETEMAIPDYIYDRCFYGKDSHSQKAKPIVEWLKKYPKTEFIG RGLPDKWTVLHDLQQHSVINPYIPETIKVSRYEQIHSFLSKEKACILKPAFGAGGRGV ILLKLGKKNITATYHIGKDKQTKTFSNQTSFKTWCKKVLQHQYLLQPYLNIQDKEQYP CDIRLFMEKNEAGEWNTVGKAVRRGYKHGLLANLSGGSDALTFDSWFEDIPKKQQVVL LDDVFSITQSVPYYLDERYGPLFELGLDICLAKDGRIWILDINSKPGRKSILRVSPEQ KEQLYTCPLKRCQYLFSEQSQKGVLPRES*" /label="spaC CDS" gene complement(976387..977478) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /label="spaC gene" promotor_-10 complement(976802..976816) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(976814) /Source="Nicolas_upshifts" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(976830..976838) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(977479..977584) /Source="Nicolas_S_feature" /locus_tag="new_1053254_1053359_c" /HighExp="S4, B36, S5, S6, S7, S8, B60, S3, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S343" promotor_-10 complement(977568..977586) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(977588) /Source="Nicolas_upshifts" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(977602..977607) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 977650..977657 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 977672..977691 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 977683 /Source="Nicolas_upshifts" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="upshifts" CDS 977745..978878 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16684363" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388860.1" /db_xref="EnsemblGenomes-Gn:BSU09790" /db_xref="EnsemblGenomes-Tr:CAB12818" /db_xref="GOA:O07543" /db_xref="InterPro:IPR007383" /db_xref="InterPro:IPR016991" /db_xref="SubtiList:BG13034" /db_xref="UniProtKB/Swiss-Prot:O07543" /translation="MGIAGTFIFMIVIGAAIGAVTNHLAIQMLFRPYKAYYLFGKRVP FTPGLIPRRRDELAKQMGLMVVNHLLTPEGIKKRLVSDAAKTQALRVGEQLIQKLSLS EVTVKEALEKAGMKRPEKAADAWISSWTDDKLHELFRQYGDQSLKELVPIEVQEKLEE KIPMISGYILSRSVRYFESDEGKIRLGNMIDDFLKERGMLGSMVQLFLGNSSLADRVL PELLKFLRNEETNKLLSDLLKNEWGKLREYTFNEADEKWNAKALIFSLKRRVLQAFST APFFNNTIGTLTVRYESELTQQMLPALLDKLLEGISSNLESVLKRLRLEEIVKEQVDQ FPVERLEEMVLSISKKEFKMITYLGGLLGGIIGAIQALFVILF*" /label="yheB CDS" gene 977745..978878 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /label="yheB gene" S_feature 978879..978970 /Source="Nicolas_S_feature" /locus_tag="new_1054654_1054745" /HighExp="S4, S5, S6, BT, S3, S7, dia15, B36, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S344" CDS 978971..979324 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388861.1" /db_xref="EnsemblGenomes-Gn:BSU09800" /db_xref="EnsemblGenomes-Tr:CAB12819" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="PDB:2OEE" /db_xref="SubtiList:BG13033" /db_xref="UniProtKB/Swiss-Prot:O07542" /translation="MAVNFYDVAYDLENALRGSEEFTRLKNLYDEVNADESAKRMFEN FRDVQLRLQQKQMAGEEITQEEVTQAQKTVALVQQHEKISQLMEAEQRMSMLIGELNK IIMKPLEELYGSVEG*" /label="yheA CDS" gene 978971..979324 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /label="yheA gene" downshifts 979312 /Source="Nicolas_upshifts" /id="D522" /incds=0 /nref=159 /ntot=259 /MaxReadThrough="1.55668" /MaxDrop="5.9901" /score="24.5275597" /energy="-12.3" /TU="NA" /idTUdmin="U780" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(979368..980441) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290, 22933559" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388862.1" /db_xref="EnsemblGenomes-Gn:BSU09810" /db_xref="EnsemblGenomes-Tr:CAB12820" /db_xref="GOA:O07541" /db_xref="InterPro:IPR011989" /db_xref="InterPro:IPR014825" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR021133" /db_xref="SubtiList:BG13002" /db_xref="UniProtKB/Swiss-Prot:O07541" /translation="MADLKEIYNEELISQLIHHVRSSYPDFNKNRFLDTLRLEDWPEL TLKERMRRVTVSLYETLPKQYVEALTILRDTAPHFKGLSGILFPDYVEQYGLAHWEES IKALESFTQYSTSEFAVRPFLLLDQEKMIAQLLAWSEHKNEHVRRLASEGSRPRLPWG KSIPALKSDPSPVLPILEKLMQDESLYVRKSVANNLNDISKTHPHLLRKVADQWYGTH PHTDWIIKHAYRTLLKKGDKQALALFGYENADSIQLHDLTCQPKRIVIGESLEFSFYI HSDRDQKVRIEYAIDFVKARGQRHQKVFKITETNIRKNETKSYTRIQSFKDLTTRKHY KGIHTLSVIINGEVKDSLDFQVC*" /label="yhaZ CDS" gene complement(979368..980441) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /label="yhaZ gene" downshifts complement(979475) /Source="Nicolas_upshifts" /id="D523" /incds=1 /nref=16 /ntot=173 /MaxReadThrough="3.78071" /MaxDrop="3.586" /score="4.43596345" /energy="-12.3" /TU="U781" /idTUdmin="U781" /TUdmin="-109" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(980463..980482) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(980475) /Source="Nicolas_upshifts" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(980496..980503) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 980578..980585 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 980598 /Source="Nicolas_upshifts" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 980600..980619 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 980609..980762 /Source="Nicolas_S_feature" /locus_tag="new_1056384_1056537" /HighExp="M9-stat, BC, T0.30H, T1.30H, Lbstat, T1.0H, T3.30H, T2.0H, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S345" downshifts 980719 /Source="Nicolas_upshifts" /id="D524" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="7.40404" /MaxDrop="2.6506" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" S_feature 980764..980847 /Source="Nicolas_S_feature" /locus_tag="new_1056539_1056622" /HighExp="M9-stat, B60, T2.0H, T1.30H, T0.30H, T2.30H, T3.0H, T1.0H, Lbtran, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S346" downshifts 980804 /Source="Nicolas_upshifts" /id="D525" /incds=0 /nref=70 /ntot=231 /MaxReadThrough="4.88371" /MaxDrop="4.4099" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-971" /isTUend="FALSE" /label="downshifts" promotor_-35 980860..980865 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 980881..980899 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 980890 /Source="Nicolas_upshifts" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="upshifts" CDS 980927..981793 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388864.2" /db_xref="EnsemblGenomes-Gn:BSU09830" /db_xref="EnsemblGenomes-Tr:CAB12822" /db_xref="GOA:O07539" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR036412" /db_xref="PDB:3DNP" /db_xref="SubtiList:BG13000" /db_xref="UniProtKB/Swiss-Prot:O07539" /translation="MSKQLLALNIDGALLRSNGKIHQATKDAIEYVKKKGIYVTLVTN RHFRSAQKIAKSLKLDAKLITHSGAYIAEKIDAPFFEKRISDDHTFNIVQVLESYQCN IRLLHEKYSIGNKKKVNSNLLGKALIHPSDPIFYPVQFVESLSDLLMDEPVSAPVIEV YTEHDIQHDITETITKAFPAVDVIRVNDEKLNIVPKGVSKEAGLALVASELGLSMDDV VAIGHQYDDLPMIELAGLGVAMGNAVPEIKRKADWVTRSNDEQGVAYMMKEYFRMQQR KGFLDKFHMKRV*" /label="yhaX CDS" gene 980927..981793 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /label="yhaX gene" downshifts 981775 /Source="Nicolas_upshifts" /id="D526" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="3.99904" /MaxDrop="4.7771" /score="15.7706912" /energy="-16.6" /TU="U783" /idTUdmin="U782" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 981838..981841 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 981856..981875 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 981864 /Source="Nicolas_upshifts" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="upshifts" CDS 981905..983410 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /EC_number="1.3.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10498703, 21255303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498703, 21255303; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_388865.1" /db_xref="EnsemblGenomes-Gn:BSU09840" /db_xref="EnsemblGenomes-Tr:CAB12823" /db_xref="GOA:Q796V8" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023995" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG12999" /db_xref="UniProtKB/Swiss-Prot:Q796V8" /translation="MQIKIEGIHDDRLHRPLQNIANLFYEECELAYGGEEPADFVISL ALSQTDEHVTVSGEVKGTGIKEQHTKFFSPDMTEKEAFKQVKNTISYVYLNLLQAHTG ITQKWGILTGIRPTKLLHKKLQSGMSKEQAHAELKKDYLIHDEKIMLMQEIVDRQLAA VPDLYRVKDEVSIYIGIPFCPTKCAYCTFPAYAIQGQAGRVGSFLWGLHYEMQKIGEW LKEHDVKVTTIYFGGGTPTSITAEEMDLLYEEMVRSFPDVKNIREITVEAGRPDTITE EKLAVLNKYDIDRISINPQSYENETLKAIGRHHTVEETIEKYHLSRQHGMNNINMDLI IGLPGEGVKEFRHSLSETEKLMPESLTVHTLSFKRASEMTRNKHKYKVAGREEVSQMM EDAVAWTKEHGYVPYYLYRQKNILGNLENVGYSLPGQESIYNIMIMEEVQTIIGIGCG AASKFIDRDTGKITHFANPKDPKSYNERFEHYTDEKIKYLEQIFEKTTKQH*" /label="hemZ CDS" gene 981905..983410 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /label="hemZ gene" downshifts 983380 /Source="Nicolas_upshifts" /id="D527" /incds=0 /nref=113 /ntot=234 /MaxReadThrough="0.523269999999999" /MaxDrop="5.05369" /score="38.1573779" /energy="-14.4" /TU="NA" /idTUdmin="U783" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(983428..984645) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7934942, 14987767, 15849754, 15919996, 16850406, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934942, 14987767, 15849754, 15919996, 16850406, 24330391; Product type t : transporter" /codon_start=1 /transl_table=11 /product="proton/potassium antiporter; methylglyoxal resistance" /protein_id="NP_388866.2" /db_xref="EnsemblGenomes-Gn:BSU09850" /db_xref="EnsemblGenomes-Tr:CAB12825" /db_xref="GOA:O07536" /db_xref="InterPro:IPR006153" /db_xref="SubtiList:BG12997" /db_xref="UniProtKB/Swiss-Prot:O07536" /translation="MDHLVFEVGTALVLVAIASVIANKIKFSIIPFLIVLGMLVGPHA PKMGIIDLTFIQSSEIIEFFGRMGVLFLLFYLGLEFSVGKLIKSGKSIAVGGTIYILI NFSLGLLYGFITGFSFLEVLILAGVITISSSAIVAKVLVDLKRTANPETELILGIIMF EDIFLAVYLSVVSGLILGDATSVGSALLSILIAFGYMLLFFIAARKLPPLLNKLLDIR SNEVFIIVIFAALFFIAGFSETIHVAEAIGALLLGLVFSETEHSDRIEHLVVPFRDFF GAMFFFSFGLSIDPFSLGEAVWLALGAVILTILGNFIAGMVAGRRAGLSHKASSNIGL TIVSRGEFSIIVANLGIAGGLSATLKPFAALYVLILAILGPLVTKESKRIYRLLNKVF KWKPEVQPAKKQG*" /label="khtU CDS" gene complement(983428..984645) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /label="khtU gene" downshifts complement(983434) /Source="Nicolas_upshifts" /id="D528" /incds=0 /nref=154 /ntot=249 /MaxReadThrough="1.74386" /MaxDrop="6.8685" /score="8.64654688" /energy="-14.4" /TU="NA" /idTUdmin="U785" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(984652..985149) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388867.1" /db_xref="EnsemblGenomes-Gn:BSU09860" /db_xref="EnsemblGenomes-Tr:CAB12826" /db_xref="GOA:O07535" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG12996" /db_xref="UniProtKB/Swiss-Prot:O07535" /translation="MNIKENDLPGIGKKFEIETRSHEKMTIIIHDDGRREIYRFNDRD PDELLSNISLDDSEARQIAAILGGMVYKPQALESIEMAFSDLIIEWFKVEKGAKSIGR TLGELDVRQNYDVTVIAIIKHNQEKLLNPGADSIIEENDTLVLSGERKHLKKLIHDFL SGEGV*" /label="khtT CDS" gene complement(984652..985149) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /label="khtT gene" CDS complement(985213..985551) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388868.1" /db_xref="EnsemblGenomes-Gn:BSU09870" /db_xref="EnsemblGenomes-Tr:CAB12827" /db_xref="GOA:O07534" /db_xref="SubtiList:BG12995" /db_xref="UniProtKB/Swiss-Prot:O07534" /translation="MRREERNMDKLLISFLLSLFMVYFPPSDVVLPSQFEASTDSYVP MSSYPQETQSAKTPSPGSMHPAELIKEYSPLAQSVRQLSVKPLDEPLINRLEKALAVP VKYQSNYLRI*" /label="khtS CDS" gene complement(985213..985551) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /label="khtS gene" promotor_-10 complement(985563..985582) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(985587) /Source="Nicolas_upshifts" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(985596..985603) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 985623..985630 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 985645..985664 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 985655 /Source="Nicolas_upshifts" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="upshifts" CDS 985716..986483 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22961985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase / isomerase" /protein_id="NP_388869.3" /db_xref="EnsemblGenomes-Gn:BSU09880" /db_xref="EnsemblGenomes-Tr:CAB12828" /db_xref="GOA:O07533" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12994" /db_xref="UniProtKB/Swiss-Prot:O07533" /translation="MEFVQYACNGAVAEIILNRPDAHHALNEQMLSELKEAVEMAAAS EALIVLLRGSGKGFSAGGDIRMMTSEHDPDQFKRLMDTIEAVTLNLYQMKKVTIAAIH GAAAGLGLSLALCADIVLAEKNAVLAMNFIGIGLVPDGGGHYLLKKRIGEAKAKKLIW SGKKLSASEAADMGLLDGTFAGDPAEGARPIIETLLASPLLAMIETKGIFQSLQIEEL KKVLSLERSAQERMRRTKDHQEGIRAFLEKREPKFQA*" /label="yhaR CDS" gene 985716..986483 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /label="yhaR gene" downshifts 986484 /Source="Nicolas_upshifts" /id="D529" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="1.78111" /MaxDrop="4.66019" /score="-8.79921781" /energy="-7.5" /TU="NA" /idTUdmin="U786" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(986504..986689) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097698.1" /db_xref="EnsemblGenomes-Gn:BSU09889" /db_xref="EnsemblGenomes-Tr:CAX52586" /db_xref="InterPro:IPR025544" /db_xref="UniProtKB/Swiss-Prot:C0H3Y1" /translation="MADYFLTVFDPSGNTLVNEQFEAEHEEAAKTHGEALLKEKELHS HTHRLVNAAGKLILFHR*" /label="yhzD CDS" gene complement(986504..986689) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /label="yhzD gene" promotor_-10 complement(986725..986743) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(986736) /Source="Nicolas_upshifts" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(986754..986762) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 986763..986766 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 986781..986800 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 986791 /Source="Nicolas_upshifts" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="upshifts" CDS 986816..987712 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 12374817; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388870.2" /db_xref="EnsemblGenomes-Gn:BSU09890" /db_xref="EnsemblGenomes-Tr:CAB12829" /db_xref="GOA:C0SPB4" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12993" /db_xref="UniProtKB/Swiss-Prot:C0SPB4" /translation="MLTIDHVTKTFGDYKAVDGLDLDIPEQQMFGLLGANGAGKTTTF RMILGLLSITEGSISWKGRPVNYHISNKIGYLPEERGLYPKMKVRDQLVYLARLKGME KREAVKELGTWLERFNITDYENKKVEELSKGNQQKIQFISAVLHKPELLILDEPFSGL DPVNVELLKEAVISLKNSGVSILFSSHRMEHVEELCENLCILQKGKPVVQGKLKEIKR SFGKKNVTIHSDDDLRFLQSHEGILQWKETADGVKLQIANEDISQEIFAMLQGKGFIR KFELEEPSLHDIFIEKVGAVYE*" /label="yhaQ CDS" gene 986816..987712 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /label="yhaQ gene" CDS 987705..988964 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent exporter (ABC permease)" /protein_id="NP_388871.2" /db_xref="EnsemblGenomes-Gn:BSU09900" /db_xref="EnsemblGenomes-Tr:CAB12830" /db_xref="GOA:O07523" /db_xref="SubtiList:BG12992" /db_xref="UniProtKB/Swiss-Prot:O07523" /translation="MNKFWIMLSHTYKNKIMAKSFIISTVITVLLVLVVTNLESIISL FQGDDAKEKIAVVDETNELYPVFSKQLKAVDTDGDLDVKLSKQSEDEVTKQVKDESLD GMLIIKRDEKGTISGTYKALTISDESTYQTLQQALTQTKTAVGTAELGVSQETISSLY APVTVGQKALKEGAKSEEELGQTVGLVYIMLFVIYFSVIMYASMIAMEVATEKSSRVM EILISSMPPIQQMFAKLLGIGLVGITQLAIIIGAGSLSLKLNQKSETASSVGGFLNLT DVSATTVIYAVIFFLLGYFLYATLAAFLGSVVSRIEDVQQTITPMTLLVVAGFMIAMF GLNAPDAGFITVTSFIPFFTPMIMFLRVGMLDIPFWQAAVGIGITLLTIVILAVIGAR IYKGGVLIYGNSSAFKAIKQALRLAKN*" /label="yhaP CDS" gene 987705..988964 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /label="yhaP gene" downshifts 988948 /Source="Nicolas_upshifts" /id="D530" /incds=0 /nref=19 /ntot=187 /MaxReadThrough="2.50232" /MaxDrop="3.26822" /score="8.93460501" /energy="-12.8" /TU="NA" /idTUdmin="U788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 989012..989019 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 989031..989050 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 989036 /Source="Nicolas_upshifts" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="upshifts" CDS 989071..990297 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA repair exonuclease" /protein_id="NP_388872.1" /db_xref="EnsemblGenomes-Gn:BSU09910" /db_xref="EnsemblGenomes-Tr:CAB12831" /db_xref="GOA:O07522" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR014576" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12991" /db_xref="UniProtKB/Swiss-Prot:O07522" /translation="MLTDLTFIHAADLHLDSPFYGISHLPEPIFARIKESTFASVRHM IDAAVREHVDFILLAGDLFDEANRSLKAQLFLKKQFERLRECGISVYVIFGNHDHLGG EWTPIEWPENVHIFSSAVPEEKSFFKEGRRIASIYGFSYQARALMENQAARYRRSTDA PFHIGMLHGTLSGSEGHDPYCPFTHDDLVKSGMDYWALGHIHKRQVLSAEHPAVIYPG NTQARHIKETGDKGYYLVHVTNGDISYEFQRAHDVLWEKAAVDVTEAKNMTALFQMVE DTFSKLRKKGSPVCVRLVLQGTAPEWLLEAPKGTLDEFLEALQEQEAEEERFVWPLRL DDETENEANLTNLDPFFGGLFEDIDRSDLSDVLEGLERHPVYRRHADRFSQEEVKEIK EQAQIILKRQLKVLDT*" /label="yhaO CDS" gene 989071..990297 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /label="yhaO gene" downshifts complement(989772) /Source="Nicolas_upshifts" /id="D531" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="0.0165100000000002" /MaxDrop="3.62411" /score="-5.83060322" /energy="-15.2" /TU="NA" /idTUdmin="U787" /TUdmin="-3300" /isTUend="FALSE" /label="downshifts" CDS 990302..993193 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16267290, 19906728, 21517913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267290, 19906728, 21517913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATPase involved in DNA double strand break repair and recombination" /protein_id="NP_388873.1" /db_xref="EnsemblGenomes-Gn:BSU09920" /db_xref="EnsemblGenomes-Tr:CAB12832" /db_xref="GOA:O08455" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12990" /db_xref="UniProtKB/Swiss-Prot:O08455" /translation="MTALRIISLHIYQYGKFSNRTFDFSASPVQVIYGLNEAGKTTMM SFIESMLFGFPKTKKYEPKTGGVYGGVLEAEHPEYGVLKIERTKGTAEKLSVYTEKGE VKQGDVLKQLFQGTDRSLYKAIYSFDVFGLQEIHAFNRDKIGEFLLFSSLFGAEAVSK LDSRLTKESERLYKPNGRNPQLNQELETLKQLAVKLKQAEAEEAGYHQLLEEKRTLEA RLAAAETELKETAGHIRMIEGAIERKPLLNEKATLEQVIAEFPEHAGQFPADGLHQLE KYESHLHPKSAQLEALRVKMAELDKQRQKLIPDKELLAKETLIQELSAAFHMYQSWGE QLAAIQAQLRQTSAQTAAGLEQLNKTDENELLNMNTSYDYEWQLQQAVQQYVQARDRK RQLDETFELARQELEDAEKAVRAASSAILENSQRKDKEAALRAYDETQGQHQEQAKLR EQLTFFERQQAKQKKTVIAAGMLFIVLFSLLQQWIPAISFGAALIVYWLVSGKSSSRN SRETRQPMTDISPAEAEMLREALWEDDRNKQHLLTQRAALQQKEAAYERVIQQFEQWE AEMAPSFTQVERFMNELGFKEDPSFLLDAYSLMKDVKKEVKKKHELTIEAGRLKKHRR TFEERVSMLLPVNQSQDISISDALHTLRKNIEREKEIEKQKKEIETDIHYTKEQMLEL EQEIQYFHAQIEQLFAAAAAKDRDAFFAIAAISRQLKDTENKLHHVNAQLQGGYPEEL ELADSNTLSELKDKQFVENERKERLTEEIEQLRSQIALLSVKQEQLEASGMVSDLKLQ TEMQKERVKETAKKWASIQMVKQVIRNKLERHKKIELPRLLETAGEFFRPLTDGNYQT IYFSETDDSIMVMHRDGTVYHAEELSQGTCEQLYTAIRFALAVTRQGESKLPFQLDDS FVHFDQERLKRVLHVLYDLSEGGRQILYFTCHEHVKDAFHSSQIIHLVS*" /label="sbcE CDS" gene 990302..993193 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /label="sbcE gene" promotor_-35 991583..991588 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 991604..991622 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 991610 /Source="Nicolas_upshifts" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 993201..993206 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 993221..993240 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 993236 /Source="Nicolas_upshifts" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="upshifts" CDS 993267..994211 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 16267290, 19553197, 19880604" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 16267290, 19553197, 19880604; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3'-5' exonuclease" /protein_id="NP_388874.1" /db_xref="EnsemblGenomes-Gn:BSU09930" /db_xref="EnsemblGenomes-Tr:CAB12833" /db_xref="GOA:O07521" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020873" /db_xref="SubtiList:BG12989" /db_xref="UniProtKB/Swiss-Prot:O07521" /translation="MAKGIMLHEVGEQVDQYLLIKSSTKGIASNGKPFLTLMLQDQSG DIEAKLWDAKQSDEVTYAPQTIVKVVGDVHHYRGRTQLKLRNIRPVSEQENVNIDDFL ETAPIPKNEMMDTITQYIFEMKNPNIQRITRFLVKKHEAEFMDYPAATKNHHEFVSGL AYHVVSMLNLAKAIADLYPSLDRDLLYAGVILHDLGKVKELSGPVSTSYTVEGNLLGH ISIMVTELSKAAEELQIDSEEVLILQHLILSHHGKAEWGSPKPPMVKEAEILHYIDNL DAKMNMMDRALERVKPGEYTERVFALENRSFYKPTFHK*" /label="yhaM CDS" gene 993267..994211 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /label="yhaM gene" downshifts 994189 /Source="Nicolas_upshifts" /id="D532" /incds=0 /nref=183 /ntot=261 /MaxReadThrough="3.02818" /MaxDrop="5.88173" /score="6.06919899" /energy="-15.8" /TU="NA" /idTUdmin="U789" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-35 994270..994275 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 994291..994309 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 994294 /Source="Nicolas_upshifts" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="upshifts" CDS 994336..994548 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523133; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="sporulation factor" /protein_id="NP_388875.1" /db_xref="EnsemblGenomes-Gn:BSU09940" /db_xref="EnsemblGenomes-Tr:CAB12834" /db_xref="GOA:O07520" /db_xref="InterPro:IPR025428" /db_xref="SubtiList:BG12988" /db_xref="UniProtKB/Swiss-Prot:O07520" /translation="MLFFPWWVYLCIVGIIFSAYKLVAAAKEEEKVDQAFIEKEGQIY MERMEKERERRSSQQHEEENQNHSIA*" /label="yhaL CDS" gene 994336..994548 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /label="yhaL gene" downshifts 994541 /Source="Nicolas_upshifts" /id="D533" /incds=0 /nref=8 /ntot=158 /MaxReadThrough="2.03283" /MaxDrop="6.60832" /score="62.1892984" /energy="-22" /TU="NA" /idTUdmin="U792" /TUdmin=5 /isTUend="TRUE" /label="downshifts" downshifts complement(994579) /Source="Nicolas_upshifts" /id="D534" /incds=0 /nref=97 /ntot=260 /MaxReadThrough="0.90997" /MaxDrop="9.00938" /score="52.3375501" /energy="-22" /TU="NA" /idTUdmin="U793" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(994589..995467) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12634326, 12682299, 14976191, 16516208, 25525259, 26711778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12634326, 12682299, 14976191, 16516208, 25525259, 26711778; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molecular chaperone lipoprotein" /protein_id="NP_388876.1" /db_xref="EnsemblGenomes-Gn:BSU09950" /db_xref="EnsemblGenomes-Tr:CAB12835" /db_xref="GOA:P24327" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR023059" /db_xref="InterPro:IPR027304" /db_xref="PDB:1ZK6" /db_xref="PDB:4WO7" /db_xref="SubtiList:BG10464" /db_xref="UniProtKB/Swiss-Prot:P24327" /translation="MKKIAIAAITATSILALSACSSGDKEVIAKTDAGDVTKGELYTN MKKTAGASVLTQLVQEKVLDKKYKVSDKEIDNKLKEYKTQLGDQYTALEKQYGKDYLK EQVKYELLTQKAAKDNIKVTDADIKEYWEGLKGKIRASHILVADKKTAEEVEKKLKKG EKFEDLAKEYSTDSSASKGGDLGWFAKEGQMDETFSKAAFKLKTGEVSDPVKTQYGYH IIKKTEERGKYDDMKKELKSEVLEQKLNDNAAVQEAVQKVMKKADIEVKDKDLKDTFN TSSTSNSTSSSSSNSK*" /label="prsA CDS" gene complement(994589..995467) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /label="prsA gene" downshifts complement(994777) /Source="Nicolas_upshifts" /id="D535" /incds=1 /nref=10 /ntot=127 /MaxReadThrough="7.54458" /MaxDrop="3.5906" /score="52.3375501" /energy="-22" /TU="U793" /idTUdmin="U793" /TUdmin="-187" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(995505..995524) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(995529) /Source="Nicolas_upshifts" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(995538..995545) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 995565..995574 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 995586 /Source="Nicolas_upshifts" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 995587..995606 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(995623..995637) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(995624) /Source="Nicolas_upshifts" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 995627..995713 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:20156992, 21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20156992, 21670523; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="spore assembly and germination protein" /protein_id="YP_003097699.1" /db_xref="EnsemblGenomes-Gn:BSU09958" /db_xref="EnsemblGenomes-Tr:CAX52587" /db_xref="GOA:C0H3Y2" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Y2" /translation="MSGGYSNGFALLVVLFILLIIVGAAYIY*" /label="sscA CDS" gene 995627..995713 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /label="sscA gene" promotor_-35 complement(995646..995650) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 995714..995965 /Source="Nicolas_S_feature" /locus_tag="new_1071489_1071740" /HighExp="S8, S7, S6, BT, G/S, B36, Pyr, S5, B60, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S347" CDS 995838..995924 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore and germination protein" /protein_id="YP_009513948.1" /db_xref="EnsemblGenomes-Gn:BSU09959" /db_xref="EnsemblGenomes-Tr:CCQ48595" /db_xref="GOA:L8EBJ6" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/TrEMBL:L8EBJ6" /translation="MGEVFAGGFALLVVLFILLIIIGASWLY*" /label="sscB CDS" gene 995838..995924 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /label="sscB gene" downshifts 995922 /Source="Nicolas_upshifts" /id="D536" /incds=0 /nref=28 /ntot=50 /MaxReadThrough="4.67734" /MaxDrop="4.7906" /score="14.3797211" /energy="-17.6" /TU="U794" /idTUdmin="U794" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" S_feature complement(995934..996196) /Source="Nicolas_S_feature" /locus_tag="new_1071709_1071971_c" /HighExp="LBGtran, LBGstat, LPhT, LBGexp, HPh, dia15, T0.30H, dia0, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S348" S_feature 995967..996450 /Source="Nicolas_S_feature" /locus_tag="new_1071742_1072225" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, Glucon, G/S, C90" /AntisenseName="yhaJ" /AntisenseCor="-0.22462434208606599" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S349" downshifts complement(995977) /Source="Nicolas_upshifts" /id="D537" /incds=0 /nref=153 /ntot=265 /MaxReadThrough="1.32339" /MaxDrop="6.55635" /score="34.7913848" /energy="-17.6" /TU="NA" /idTUdmin="U796" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(996189..996208) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(996196) /Source="Nicolas_upshifts" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(996198..996266) /Source="Nicolas_S_feature" /locus_tag="new_1071973_1072041_c" /HighExp="Paraq, G180, C30, LBGexp, Oxctl, G135, Lbexp, Heat, G150, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29568499999999998" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S350" promotor_-35 complement(996222..996227) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(996267..996785) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009, 21670523, 25651892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme" /protein_id="NP_388878.2" /db_xref="EnsemblGenomes-Gn:BSU09965" /db_xref="EnsemblGenomes-Tr:CAB12837" /db_xref="GOA:O07518" /db_xref="InterPro:IPR021683" /db_xref="SubtiList:BG12986" /db_xref="UniProtKB/Swiss-Prot:O07518" /translation="MNCWKTINLMKDYGAVRIILTAVCFMILVFISTFLAFELLRPGT SLSDEYVSLFGGLLVVILFVHKVIHVLPIICKKRKIEKKFYILRMRTWKRIPKTTMLI SLVSPFLLITPVLFYAALAFPNHAHYFCMISGIHAGYCLPDFLLALKLIKAPKTAFID QEADGLDILVEK*" /label="yhaJ CDS" gene complement(996267..996785) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /label="yhaJ gene" promotor_-35 996572..996580 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 996592..996610 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 996605 /Source="Nicolas_upshifts" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(996816..996835) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(996834) /Source="Nicolas_upshifts" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(996851..996857) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 996934..996937 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 996952..996971 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 996957 /Source="Nicolas_upshifts" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="upshifts" CDS 996993..997334 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388879.1" /db_xref="EnsemblGenomes-Gn:BSU09980" /db_xref="EnsemblGenomes-Tr:CAB12838" /db_xref="InterPro:IPR015058" /db_xref="InterPro:IPR035945" /db_xref="PDB:1SED" /db_xref="SubtiList:BG12985" /db_xref="UniProtKB/Swiss-Prot:O07517" /translation="MDSMDHRIERLEYYIQLLVKTVDMDRYPFYALLIDKGLSKEEGE AVMRICDELSEELATQKAQGFVTFDKLLALFAGQLNEKLDVHETIFALYEQGLYQELM EVFIDIMKHFD*" /label="yhaI CDS" gene 996993..997334 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /label="yhaI gene" S_feature complement(997188..997330) /Source="Nicolas_S_feature" /locus_tag="new_1072963_1073105_c" /HighExp="BC, S1, Sw, S2, S3, S8, S5, S4, S6, S7" /AntisenseName="yhaI" /AntisenseCor="5.4889858269512502E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S351" downshifts complement(997231) /Source="Nicolas_upshifts" /id="D538" /incds=1 /nref=39 /ntot=209 /MaxReadThrough="2.89899" /MaxDrop="4.77791" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(997331..997942) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of extracellular protease production, sporulation and bacilysin production (MarR family)" /protein_id="NP_388880.1" /db_xref="EnsemblGenomes-Gn:BSU09990" /db_xref="EnsemblGenomes-Tr:CAB12839" /db_xref="GOA:P11065" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR023488" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FXA" /db_xref="SubtiList:BG10659" /db_xref="UniProtKB/Swiss-Prot:P11065" /translation="MNRVEPPYDVKEALVFTQKMAQLSKALWKSIEKDWQQWLKPYDL NINEHHILWIAYQLNGASISEIAKFGVMHVSTAFNFSKKLEERGYLRFSKRLNDKRNT YVQLTEEGTEVFWSLLEEFDPTRNAVFKGSQPLYHLFGKFPEVAEMMCMIRHIYGDDF MEIFETSLTNIDNDFESVNGKLKKKAKDSAADEPAEELEPVNS*" /label="scoC CDS" gene complement(997331..997942) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /label="scoC gene" S_feature 997335..998100 /Source="Nicolas_S_feature" /locus_tag="new_1073110_1073875" /HighExp="Lbstat, Etha, T0.30H, Gly, M0t90, M40t90, M40t45, M0t45, H2O2, dia15" /AntisenseName="scoC" /AntisenseCor="-0.46322626361720198" /AntisenseRegPval="-15" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S352" downshifts complement(997407) /Source="Nicolas_upshifts" /id="D539" /incds=1 /nref=1 /ntot=81 /MaxReadThrough="5.81117" /MaxDrop="2.1632" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" promotor_-35 997938..997942 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 997950..997963 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 997962 /Source="Nicolas_upshifts" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(997967..997986) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-10" upshifts complement(997990) /Source="Nicolas_upshifts" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="upshifts" promotor_-35 complement(998001..998004) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-35" downshifts 998057 /Source="Nicolas_upshifts" /id="D540" /incds=0 /nref=1 /ntot=124 /MaxReadThrough="3.007" /MaxDrop="2.86547" /score="17.8486533" /energy="-7.1" /TU="U799,U800" /idTUdmin="U799" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(998120..998476) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11429463; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein; acid tolerance protein" /protein_id="NP_388881.1" /db_xref="EnsemblGenomes-Gn:BSU10000" /db_xref="EnsemblGenomes-Tr:CAB12840" /db_xref="GOA:O07516" /db_xref="InterPro:IPR024623" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12984" /db_xref="UniProtKB/Swiss-Prot:O07516" /translation="MASGRSLLTGLFVGGIIGGAAVLLTAPSSGKQLREKMKTNYDSF EETIKRLKSDGLALKDQLIKAAKESTDVIKDVGGELQTSIKKWQEEIKPHQQDLQKEI ADIEEKIRQLEKTLQN*" /label="yhaH CDS" gene complement(998120..998476) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /label="yhaH gene" downshifts complement(998124) /Source="Nicolas_upshifts" /id="D541" /incds=0 /nref=254 /ntot=287 /MaxReadThrough="1.65317" /MaxDrop="7.37381" /score="10.8990112" /energy="-7.9" /TU="NA" /idTUdmin="U804" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 998553..998558 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(998559..998578) /Source="Nicolas_upshift_promotors" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(998573) /Source="Nicolas_upshifts" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 998574..998592 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 998574 /Source="Nicolas_upshifts" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(998575..998838) /Source="Nicolas_S_feature" /locus_tag="new_1074350_1074613_c" /HighExp="Etha, Salt, HiTm, Heat, Diami, Sw, Gly, S1, MG 10, MG 60" /AntisenseName="yhzF" /AntisenseCor="-0.69425315975357205" /AntisenseRegPval="-39.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S353" CDS 998606..998797 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="membrane protein of unknown function" /protein_id="YP_003097700.1" /db_xref="EnsemblGenomes-Gn:BSU10009" /db_xref="EnsemblGenomes-Tr:CAX52588" /db_xref="GOA:C0H3Y3" /db_xref="UniProtKB/Swiss-Prot:C0H3Y3" /translation="MSVFLIVLSCITLAFASGAVYYIKLLSQAASYPPKRVIRQKALV CSTGTAFTLCLIFFTKLLA*" /label="yhzF CDS" gene 998606..998797 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /label="yhzF gene" S_feature 998798..1000233 /Source="Nicolas_S_feature" /locus_tag="new_1074573_1076008" /HighExp="S3, S8, S4, S6, S7, T5.0H, C30, S5, T4.0H, T3.30H" /AntisenseName="trpP" /AntisenseCor="-0.20038256384636899" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S354" CDS complement(998871..999389) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735881, 14702295, 15849754, 16850406, 16879415, 17114263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735881, 14702295, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="tryptophan transporter or sensor" /protein_id="NP_388882.2" /db_xref="EnsemblGenomes-Gn:BSU10010" /db_xref="EnsemblGenomes-Tr:CAB12841" /db_xref="GOA:O07515" /db_xref="InterPro:IPR031360" /db_xref="SubtiList:BG12983" /db_xref="UniProtKB/Swiss-Prot:O07515" /translation="MKTKELVIMALFAAIGAALHSIIPPFLGGMKPDMMLIMMFMGIL LFPRVQNVLVIGIVTGIISALTTAFPAGQIPNIIDKPVSAFLFFSLFLLFRKSRKTGA AAVLTVIGTILSGIVFLSSALLIVGLPGGFAALFAAVVLPAAVLNTISMIIIYPIVQT ILRRSSFMEAAK*" /label="trpP CDS" gene complement(998871..999389) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /label="trpP gene" downshifts complement(998883) /Source="Nicolas_upshifts" /id="D542" /incds=0 /nref=105 /ntot=253 /MaxReadThrough="6.00956" /MaxDrop="4.62812" /score="24.5949542" /energy="-12.8" /TU="U804,U805,U806" /idTUdmin="U804" /TUdmin="-750" /isTUend="FALSE" /label="downshifts" S_feature complement(999390..999477) /Source="Nicolas_S_feature" /locus_tag="new_1075165_1075252_c" /HighExp="C90, B60, S1, GM 15, MG 45, MG-0.2, Etha, Lbtran, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S355" promotor_-10 complement(999469..999488) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(999477) /Source="Nicolas_upshifts" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(999502..999509) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(999514..1000593) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /EC_number="2.6.1.52" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4337849, 16233211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4337849, 16233211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine aminotransferase" /protein_id="NP_388883.1" /db_xref="EnsemblGenomes-Gn:BSU10020" /db_xref="EnsemblGenomes-Tr:CAB12842" /db_xref="GOA:P80862" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR022278" /db_xref="SubtiList:BG12673" /db_xref="UniProtKB/Swiss-Prot:P80862" /translation="MERTTNFNAGPAALPLEVLQKAQKEFIDFNESGMSVMELSHRSK EYEAVHQKAKSLLIELMGIPEDYDILFLQGGASLQFSMLPMNFLTPEKTAHFVMTGAW SEKALAETKLFGNTSITATSETDNYSYIPEVDLTDVKDGAYLHITSNNTIFGTQWQEF PNSPIPLVADMSSDILSRKIDVSKFDVIYGGAQKNLGPSGVTVVIMKKSWLQNENANV PKILKYSTHVKADSLYNTPPTFAIYMLSLVLEWLKENGGVEAVEQRNEQKAQVLYSCI DESNGFYKGHARKDSRSRMNVTFTLRDDELTKTFVQKAKDAKMIGLGGHRSVGGCRAS IYNAVSLEDCEKLAAFMKKFQQENE*" /label="serC CDS" gene complement(999514..1000593) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /label="serC gene" misc_feature complement(1000632..1000651) /Source="Nicolas_upshift_promotors" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1000643) /Source="Nicolas_upshifts" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1000645..1000726) /Source="Nicolas_S_feature" /locus_tag="new_1076420_1076501_c" /HighExp="Etha, dia15, H2O2, LBGtran, G135, G180, dia5, G150, Lbexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S356" CDS complement(1000740..1001177) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /EC_number="3.6.1.29" /EC_number="3.6.1.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579061, 15703176, 16934294, 17217311, 26181368, 28516732; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous Hit-family phosphohydrolase, adenosine phosphoramidase" /protein_id="NP_388884.1" /db_xref="EnsemblGenomes-Gn:BSU10030" /db_xref="EnsemblGenomes-Tr:CAB12843" /db_xref="GOA:O07513" /db_xref="InterPro:IPR001310" /db_xref="InterPro:IPR011146" /db_xref="InterPro:IPR019808" /db_xref="InterPro:IPR036265" /db_xref="PDB:1Y23" /db_xref="SubtiList:BG12607" /db_xref="UniProtKB/Swiss-Prot:O07513" /translation="MHCAENCIFCKIIAGDIPSAKVYEDEHVLAFLDISQVTKGHTLV IPKTHIENVYEFTDELAKQYFHAVPKIARAIRDEFEPIGLNTLNNNGEKAGQSVFHYH MHIIPRYGKGDGFGAVWKTHADDYKPEDLQNISSSIAKRLASS*" /label="hinT CDS" gene complement(1000740..1001177) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /label="hinT gene" downshifts complement(1000771) /Source="Nicolas_upshifts" /id="D543" /incds=0 /nref=187 /ntot=248 /MaxReadThrough="4.31506" /MaxDrop="5.61862" /score="-0.366845751" /energy="-8.6" /TU="U806" /idTUdmin="U807" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1001210..1001229) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1001224) /Source="Nicolas_upshifts" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" downshifts 1001227 /Source="Nicolas_upshifts" /id="D544" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.3752" /MaxDrop="3.02008" /score="-3.56654132" /energy="-13.3" /TU="NA" /idTUdmin="U803" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" promotor_-35 complement(1001243..1001250) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1001249..1001545) /Source="Nicolas_S_feature" /locus_tag="new_1077024_1077320_c" /HighExp="S7, S8, S6, S5, BT, ferm, nit, G/S, S4, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S357" downshifts complement(1001292) /Source="Nicolas_upshifts" /id="D545" /incds=0 /nref=40 /ntot=72 /MaxReadThrough="3.07347" /MaxDrop="7.69075" /score="9.88617558" /energy="-14.2" /TU="U807" /idTUdmin="U807" /TUdmin="-517" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1001543..1001554) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1001549) /Source="Nicolas_upshifts" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1001569..1001575) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1001605..1001612 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1001626..1001645 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1001635 /Source="Nicolas_upshifts" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="upshifts" CDS 1001665..1002408 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 11807061, 18599827, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 11807061, 18599827, 26735940; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein)" /protein_id="NP_388885.1" /db_xref="EnsemblGenomes-Gn:BSU10040" /db_xref="EnsemblGenomes-Tr:CAB12844" /db_xref="GOA:P55339" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11516" /db_xref="UniProtKB/Swiss-Prot:P55339" /translation="MSLLSVKDLTGGYTRNPVLKNVSFTLEPNQIVGLIGLNGAGKST TIRHIIGLMDPHKGSIELNGKTFAEDPEGYRSQFTYIPETPVLYEELTLMEHLELTAM AYGLSKETMEKRLPPLLKEFRMEKRLKWFPAHFSKGMKQKVMIMCAFLAEPALYIIDE PFLGLDPLAINALLERMNEAKKGGASVLMSTHILATAERYCDSFIILHNGEVRARGTL SELREQFGMKDAALDDLYLELTKEDAGHE*" /label="ecsA CDS" gene 1001665..1002408 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /label="ecsA gene" CDS 1002401..1003627 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease subunit)" /protein_id="NP_388886.1" /db_xref="EnsemblGenomes-Gn:BSU10050" /db_xref="EnsemblGenomes-Tr:CAB12845" /db_xref="GOA:P55340" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG11517" /db_xref="UniProtKB/Swiss-Prot:P55340" /translation="MNNMLDIWQSRLQEHIKETRTYMKYMLNDHLVIVLIFFLAGAAS WYSKWIRDIPAHFPSFWVMAVLFSLVLTSSYVRTLLKEADLVFLLPLEAKMEPYLKQA FVYSYVSQLFPLIALSIVAMPLYFAVTPGASLVSYAAVFVQLLLLKAWNQVMEWRTTF QNDRSMKRMDVIIRFAANTLVLYFVFQSVYMYALLVYVIMAVLYLYMSSAAKRKTFKW ESHIESELRRKQRFYRIANLFTDVPHLRKQAKRRAYLDFLLRLVPFEQRKTFAYMFTR AFLRSSDYLGILVRLTIVFALIIMYVSASPLIAAVLTVFAIFITGIQLLPLFGHFDHL ALQELYPVQKETKLKSYFSLLKTALSIQALLMSVASAYAAGLTGFLYALIGSAVLIFV VLPAYMTTRLKKHGKL*" /label="ecsB CDS" gene 1002401..1003627 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /label="ecsB gene" promotor_-10 complement(1002960..1002978) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1002975) /Source="Nicolas_upshifts" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1002994..1002999) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1003647..1004357 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8581172, 10027970; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388887.1" /db_xref="EnsemblGenomes-Gn:BSU10060" /db_xref="EnsemblGenomes-Tr:CAB12846" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG11518" /db_xref="UniProtKB/Swiss-Prot:P55341" /translation="MTDNQLLMQEALEWKMHFLRKDSMFERFSKRVQTKVNERIPEKI HTVVTESVKKMVEATMAGSNIITYKKDTSALSLSEKNELAKKTIVSYQKVAAAEGVGT GAGGIFLSIADFPLLLSIKMKCLFTLSSIYGFDVKDAQERIFLLLVFQLAFSSDDGRK SLFSVIENWETEKKSIDWRVFQQEYRDYIDVVKLFQLLPGVGAAVGGIANYKLLAQLG ETARHVFHLRILKETAGE*" /label="ecsC CDS" gene 1003647..1004357 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /label="ecsC gene" downshifts 1004321 /Source="Nicolas_upshifts" /id="D546" /incds=0 /nref=78 /ntot=231 /MaxReadThrough="1.36097" /MaxDrop="4.78417" /score="28.5337351" /energy="-14.6" /TU="NA" /idTUdmin="U808" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(1004375..1005565) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /EC_number="3.5.1.-" /experiment="publication(s) with functional evidences, PMID:23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl amino acid acetylase, promiscuous activity" /protein_id="NP_388888.2" /db_xref="EnsemblGenomes-Gn:BSU10070" /db_xref="EnsemblGenomes-Tr:CAB12847" /db_xref="GOA:O07598" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12982" /db_xref="UniProtKB/Swiss-Prot:O07598" /translation="MSISTLQKEINKQLDGCFEEMVEIRRHFHMYPELSFQEEKTAAF IASYYESLGVPIRTNVGGRGVLANIEGSEPGPTVALRADFDALPIQDEKDVPYASKVP GVMHACGHDGHTAALLAVAKVLHQNRHELKGTFVMIHQHAEEYYPGGAKPMIDDGCLE NTDVIFGTHLWATEPLGTILCRPGAVMAAADRFTIKVFGKGGHGAHPHDTKDAVLIGS QIVSSLQHIVSRKVNPIQSAVISTGSFIADNPFNVIADQAVLIGTARSFDENVRDILE KEIEAVVKGICSMHGASYEYTYEQGYPAVVNHPAETNHLVSTAKNTEGVQQVIDGEPQ MGGEDFAYYLQNVKGTFFFTGAAPEQPERVYSHHHPKFDINEKAMLTAAKVLAGAAIT YHQL*" /label="sndC CDS" gene complement(1004375..1005565) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /label="sndC gene" downshifts complement(1004385) /Source="Nicolas_upshifts" /id="D547" /incds=0 /nref=11 /ntot=162 /MaxReadThrough="3.12546" /MaxDrop="4.15559" /score="-4.78420642" /energy="-14.6" /TU="U810" /idTUdmin="U811" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts complement(1004450) /Source="Nicolas_upshifts" /id="D548" /incds=1 /nref=25 /ntot=206 /MaxReadThrough="4.92378" /MaxDrop="3.21645" /score="-4.78420642" /energy="-14.6" /TU="U810,U811" /idTUdmin="U811" /TUdmin="-67" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1005589..1005608) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1005610) /Source="Nicolas_upshifts" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1005622..1005627) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1005638..1007029) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 12107147; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388889.1" /db_xref="EnsemblGenomes-Gn:BSU10080" /db_xref="EnsemblGenomes-Tr:CAB12848" /db_xref="GOA:O07599" /db_xref="SubtiList:BG13047" /db_xref="UniProtKB/Swiss-Prot:O07599" /translation="MMEVGILPVHVLYVFFIGAIILFMLLRKDTTFISLFGIFIISLW ASHSLSASVSSLFHSFIYAAGELLPTIFIICFIVSMSDLLTKTGINEAMISPFASLVR GPVTAYWLIGGLMFAISLFFWPSPGVALIGAVLLPAAARAGLTPLAAAMAMNLFGHGF ALSGDFVIQAAPKLTADAAGIPVGDVVSASIPLVLIMGVTTTTAAFIMIQRERKKQEH PTSFSPVLSGEQDNSLYLPKRLRSILAFLIPLAFLADIACMLLFNLQGNDATALIGGS AICILFTVHFFVYKHKGLEKITGYFIDGFKFGFKVFGPVIPIAAFFYLGDSGYESILG TSLPKGSHGIVNDLGIALSHMMPMSKELAATALTAAGAITGLDGSGFSGISLAGSIAK LFSSALHADPAILTALGQISAIWVGGGTLVPWALIPAAAICKVDPFELARKNFIPVAI GLLVTTLAAVMML*" /label="yhfA CDS" gene complement(1005638..1007029) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /label="yhfA gene" promotor_-10 complement(1007040..1007059) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1007045) /Source="Nicolas_upshifts" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1007072..1007081) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1007095..1007409) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388890.1" /db_xref="EnsemblGenomes-Gn:BSU10090" /db_xref="EnsemblGenomes-Tr:CAB12849" /db_xref="SubtiList:BG10426" /db_xref="UniProtKB/Swiss-Prot:P38048" /translation="MKHTCPVCGFKDWLNRHMIMKAIILMKSARAAVFSSDLMSTRCS TRITHIEPSESIIAYRKNWLAEGCVIFSPECFPKHLQKANRGLRHHLIEQLKQINVHL PS*" /label="yhgB CDS" gene complement(1007095..1007409) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /label="yhgB gene" CDS complement(1007454..1007954) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /EC_number="1.14.99.48" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21873409, 22531134, 24582752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21873409, 22531134, 24582752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388891.1" /db_xref="EnsemblGenomes-Gn:BSU10100" /db_xref="EnsemblGenomes-Tr:CAB12850" /db_xref="GOA:P38049" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:4OZ5" /db_xref="SubtiList:BG10427" /db_xref="UniProtKB/Swiss-Prot:P38049" /translation="MKVYITYGTADFLKTIVQKHPSENILLMQGQENAILIHETNGDT VFQAPHAYEVIDQVGEIKHPGFAVLNNIAVTQEGRPLFENRFKNRAGKVENEPGFEAI RVLRPLDSDTYVILTLWETESAFQDWQQSGSYKEAHKKRDTSAGIDTTSIFSRPSYVT TYFAVE*" /label="hmoB CDS" gene complement(1007454..1007954) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /label="hmoB gene" downshifts complement(1007481) /Source="Nicolas_upshifts" /id="D549" /incds=0 /nref=145 /ntot=254 /MaxReadThrough="3.45185" /MaxDrop="5.6374" /score="15.5142908" /energy="-14.8" /TU="U812" /idTUdmin="U812" /TUdmin="-546" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1007967..1007986) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1007969..1007973 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1007988) /Source="Nicolas_upshifts" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1007989..1008008 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1007990 /Source="Nicolas_upshifts" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1008003..1008004) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1008021..1008027 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1008042..1008053 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1008047 /Source="Nicolas_upshifts" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="upshifts" CDS 1008076..1010220 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8335642, 11567005, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8335642, 11567005, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2C (1F class) required for spore germination" /protein_id="NP_388892.2" /db_xref="EnsemblGenomes-Gn:BSU10110" /db_xref="EnsemblGenomes-Tr:CAB12851" /db_xref="GOA:P38050" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10428" /db_xref="UniProtKB/Swiss-Prot:P38050" /translation="MFKIKKKKLFIPIIILVLTAFLALIGYISIIFLGHYVIDEKKLI LHASSKIVDQNGDEVASLYTENREPVSINEIPKQVREAFIAVEDKRFYEHHGIDAKSV GRAVYRDILAGGKVEGGSTITQQLAKNIFLTHDKTFLRKTKEVIIAINLERDYSKDKL LEMYLNQLYFGHGVYGIQAASHYYFNKEVKDLTVSEGAVLAAIPKAPSTYSPILHPDK NKERRDTILGMMNDQGYISAKEAVTAQGRTLGLHVKKQSETPWFDSYIDLVIKEAEDK YSISGEQLLQGGYTIKVPLDSKLQKTAYQVMKEGSYYPGTDQNAEGSAVFINNKTGGV EAAIGGRDYTSKGYNRVTAVRQPGSTFKPLAVYGPAMQEKKFKPYSLLKDELQSYGDY TPKNYDSRYEGEVTMSDAITYSKNAPAVWTLNEIGVETGKSYLKANGIDIPDEGLALA LGGLEKGVSPLQLAGAFHTFAANGTYTEPFFISSIIDEDGETIADHKEEGKRVFSKQT SWNMTRMLQQVVKKGTATSGTYHGDLAGKTGSTSYTGVSGATKDAWFAGYTPKITGAV WMGYDKTDQNHYLKAGSSYPTRLFKDILTQAGETGHVFTKPKNVKELESPIELKPVKT LTADYTFKAAGLFTIELKWDAQEDDRAVYRIYVNKDGEETLLDSVEGKGSYEIPYANL FSGASYKIVPYNTQTKREGEGTDYVQPKLFSS*" /label="pbpF CDS" gene 1008076..1010220 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /label="pbpF gene" promotor_-10 complement(1008120..1008131) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1008123) /Source="Nicolas_upshifts" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1008145..1008151) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1010257..1010263 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1010277..1010296 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1010287 /Source="Nicolas_upshifts" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="upshifts" CDS 1010342..1011403 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /EC_number="4.1.1.37" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 17122346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 17122346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III decarboxylase" /protein_id="NP_388893.1" /db_xref="EnsemblGenomes-Gn:BSU10120" /db_xref="EnsemblGenomes-Tr:CAB12852" /db_xref="GOA:P32395" /db_xref="InterPro:IPR000257" /db_xref="InterPro:IPR006361" /db_xref="PDB:2INF" /db_xref="SubtiList:BG10429" /db_xref="UniProtKB/Swiss-Prot:P32395" /translation="MSKRETFNETFLKAARGEKADHTPVWYMRQAGRSQPEYRKLKEK YGLFEITHQPELCAYVTRLPVEQYGVDAAILYKDIMTPLPSIGVDVEIKNGIGPVIDQ PIRSLADIEKLGQIDPEQDVPYVLETIKLLVNEQLNVPLIGFSGAPFTLASYMIEGGP SKNYNKTKAFMYSMPDAWNLLMSKLADMIIVYVKAQIEAGAKAIQIFDSWVGALNQAD YRTYIKPVMNRIFSELAKENVPLIMFGVGASHLAGDWHDLPLDVVGLDWRLGIDEARS KGITKTVQGNLDPSILLAPWEVIEQKTKEILDQGMESDGFIFNLGHGVFPDVSPEVLK KLTAFVHEYSQNKKMGQYS*" /label="hemE CDS" gene 1010342..1011403 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /label="hemE gene" CDS 1011475..1012407 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /EC_number="4.99.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferrochelatase" /protein_id="NP_388894.1" /db_xref="EnsemblGenomes-Gn:BSU10130" /db_xref="EnsemblGenomes-Tr:CAB12853" /db_xref="GOA:P32396" /db_xref="InterPro:IPR001015" /db_xref="InterPro:IPR019772" /db_xref="InterPro:IPR033644" /db_xref="InterPro:IPR033659" /db_xref="PDB:1AK1" /db_xref="PDB:1C1H" /db_xref="PDB:1C9E" /db_xref="PDB:1DOZ" /db_xref="PDB:1FJI" /db_xref="PDB:1LD3" /db_xref="PDB:1N0I" /db_xref="PDB:2AC2" /db_xref="PDB:2AC4" /db_xref="PDB:2H1V" /db_xref="PDB:2H1W" /db_xref="PDB:2HK6" /db_xref="PDB:2Q2N" /db_xref="PDB:2Q2O" /db_xref="PDB:2Q3J" /db_xref="PDB:3GOQ" /db_xref="PDB:3M4Z" /db_xref="SubtiList:BG10430" /db_xref="UniProtKB/Swiss-Prot:P32396" /translation="MSRKKMGLLVMAYGTPYKEEDIERYYTHIRRGRKPEPEMLQDLK DRYEAIGGISPLAQITEQQAHNLEQHLNEIQDEITFKAYIGLKHIEPFIEDAVAEMHK DGITEAVSIVLAPHFSTFSVQSYNKRAKEEAEKLGGLTITSVESWYDEPKFVTYWVDR VKETYASMPEDERENAMLIVSAHSLPEKIKEFGDPYPDQLHESAKLIAEGAGVSEYAV GWQSEGNTPDPWLGPDVQDLTRDLFEQKGYQAFVYVPVGFVADHLEVLYDNDYECKVV TDDIGASYYRPEMPNAKPEFIDALATVVLKKLGR*" /label="hemH CDS" gene 1011475..1012407 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /label="hemH gene" CDS 1012422..1013834 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /EC_number="1.3.3.4" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9217019, 9784236, 10498703, 20543190" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9217019, 9784236, 10498703, 20543190; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous protoporphyrinogen IX and coproporphyrinogen III oxidase" /protein_id="NP_388895.1" /db_xref="EnsemblGenomes-Gn:BSU10140" /db_xref="EnsemblGenomes-Tr:CAB12854" /db_xref="GOA:P32397" /db_xref="InterPro:IPR002937" /db_xref="InterPro:IPR004572" /db_xref="InterPro:IPR036188" /db_xref="PDB:3I6D" /db_xref="SubtiList:BG10431" /db_xref="UniProtKB/Swiss-Prot:P32397" /translation="MSDGKKHVVIIGGGITGLAAAFYMEKEIKEKNLPLELTLVEASP RVGGKIQTVKKDGYIIERGPDSFLERKKSAPQLVKDLGLEHLLVNNATGQSYVLVNRT LHPMPKGAVMGIPTKIAPFVSTGLFSLSGKARAAMDFILPASKTKDDQSLGEFFRRRV GDEVVENLIEPLLSGIYAGDIDKLSLMSTFPQFYQTEQKHRSLILGMKKTRPQGSGQQ LTAKKQGQFQTLSTGLQTLVEEIEKQLKLTKVYKGTKVTKLSHSGSCYSLELDNGVTL DADSVIVTAPHKAAAGMLSELPAISHLKNMHSTSVANVALGFPEGSVQMEHEGTGFVI SRNSDFAITACTWTNKKWPHAAPEGKTLLRAYVGKAGDESIVDLSDNDIINIVLEDLK KVMNINGEPEMTCVTRWHESMPQYHVGHKQRIKELREALASAYPGVYMTGASFEGVGI PDCIDQGKAAVSDALTYLFS*" /label="hemY CDS" gene 1012422..1013834 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /label="hemY gene" downshifts 1012425 /Source="Nicolas_upshifts" /id="D550" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="7.68191" /MaxDrop="2.667" /score="28.7532434" /energy="-11.6" /TU="U813,U816" /idTUdmin="U814" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1013811 /Source="Nicolas_upshifts" /id="D551" /incds=0 /nref=195 /ntot=254 /MaxReadThrough="2.9859" /MaxDrop="6.7703" /score="28.7532434" /energy="-11.6" /TU="NA" /idTUdmin="U813" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1013895..1013902 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1013916..1013935 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1013921 /Source="Nicolas_upshifts" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="upshifts" CDS 1013980..1014555 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15944459, 23695570; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown target" /protein_id="NP_388896.1" /db_xref="EnsemblGenomes-Gn:BSU10150" /db_xref="EnsemblGenomes-Tr:CAB12855" /db_xref="GOA:P32398" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10432" /db_xref="UniProtKB/Swiss-Prot:P32398" /translation="MSIDRKKLILEAATKSFTQFGYKATTMDLVAKLANVGKGTIYTF FKNKEELFDEIFTTLLKEMKQKADEAMEPSLPFHENVHRALFAILEFRKTHQLTIKIF QENAEIGTMAVQEVIQKMERSILSYIKSKIEDGIKSGAIKPCDPELTAFVMLKLYIAL IFDWEKQHPPLDKETIAGLLELYVVKGLSAN*" /label="yhgD CDS" gene 1013980..1014555 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /label="yhgD gene" promotor_-35 1014299..1014302 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1014317 /Source="Nicolas_upshifts" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1014319..1014338 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1014556..1014625 /Source="Nicolas_S_feature" /locus_tag="new_1090331_1090400" /HighExp="G135, G150, G180, BI, Salt, Etha, Cold, Heat, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.731, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S358" CDS 1014626..1016953 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576783; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting protein" /protein_id="NP_388897.1" /db_xref="EnsemblGenomes-Gn:BSU10160" /db_xref="EnsemblGenomes-Tr:CAB12856" /db_xref="GOA:P32399" /db_xref="InterPro:IPR017500" /db_xref="InterPro:IPR017501" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR023908" /db_xref="SubtiList:BG10433" /db_xref="UniProtKB/Swiss-Prot:P32399" /translation="MNTIRSQWKDIVTSKKLLIPIIAILFVPLIYSGVFLKAYWDPYG TVDQLPVVVVNQDKGATYEGEKLQIGDDLVKELKDNNNFDWHFSNDLDQSLKDLLNQK YYLVVEIPEDFSKNASTVLDKNPKKLDLKYHTNAGSNYVGATIGEKAIDKLKASVSKE VTEQYTKVIFDNFKDIAKGLSDASSGAKKIDDGTKDAKNGSAQLKENLAKLKESTATI SDKTAQLADGAAQVTSGIQSLDSSLGKFQDSSNQIYDKSSQLAAGSGELTSKMNELLA GLQNVQKGTPNLTNGLDQLNSKVQEGSEKAAKAEKIINALDLTKLETAVNNLEKSETA MKEFKKQLTDFENSLKNRDQAFKNVINSSDFLTAEQKSQLINSVEKKLPQVDAPDFDQ ILSQLPTADQLPDIATIKSSLEDVKAQVAQVKAMPEATSKLYNGAKTIQDAIDRLTEG ADKIYNGSQKLTDGQTKLTAGIGEYNKQFAKAKAGSEQLVTGSSQVSGGLFKLLDGSK QVQSGSSKLADGSASLDTGLGKLLDGTGELSSKLKDAADQTGDIDADDQTYGMFADPV KTKDDAIHSVPNYGTGLTPYILSMGLYVGGIMLTVVFPLKEASGRPRNGFEWFFSKFN VMMLVGIIQSLIVATVLLLGIGLEVESTWRFYVFTIITSLAFLAIIQFLATTMGNPGR FIAVIILVLQLGASGGTFPLELLPNFYQVIHGALPMTYSINGFRAVISNGDFGYMWQM AGVLIGIALVMIALSITYFTMLSRKEETSEEQPAS*" /label="yhgE CDS" gene 1014626..1016953 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /label="yhgE gene" downshifts 1016935 /Source="Nicolas_upshifts" /id="D552" /incds=0 /nref=65 /ntot=211 /MaxReadThrough="0.57274" /MaxDrop="5.58483" /score="-4.79013797" /energy="-7.3" /TU="NA" /idTUdmin="U817" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1016995..1017972) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 21383089, 21542858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 21383089, 21542858; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 2" /protein_id="NP_388898.1" /db_xref="EnsemblGenomes-Gn:BSU10170" /db_xref="EnsemblGenomes-Tr:CAB12857" /db_xref="GOA:O07600" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13048" /db_xref="UniProtKB/Swiss-Prot:O07600" /translation="MSKAKITAIGTYAPSRRLTNADLEKIVDTSDEWIVQRTGMRERR IADEHQFTSDLCIEAVKNLKSRYKGTLDDVDMILVATTTSDYAFPSTACRVQEYFGWE STGALDINATCAGLTYGLHLANGLITSGLHQKILVIAGETLSKVTDYTDRTTCVLFGD AAGALLVERDEETPGFLASVQGTSGNGGDILYRAGLRNEINGVQLVGSGKMVQNGREV YKWAARTVPGEFERLLHKAGLSSDDLDWFVPHSANLRMIESICEKTPFPIEKTLTSVE HYGNTSSVSIVLALDLAVKAGKLKKDQIVLLFGFGGGLTYTGLLIKWGM*" /label="fabHB CDS" gene complement(1016995..1017972) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /label="fabHB gene" downshifts complement(1017008) /Source="Nicolas_upshifts" /id="D553" /incds=0 /nref=21 /ntot=217 /MaxReadThrough="1.99012" /MaxDrop="7.90433" /score="-9.17544275" /energy="-7.3" /TU="NA" /idTUdmin="U819" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1017986..1018005) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1018004) /Source="Nicolas_upshifts" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1018019..1018025) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1018031..1018039 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1018050..1018068 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1018057 /Source="Nicolas_upshifts" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="upshifts" CDS 1018099..1018875 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388899.1" /db_xref="EnsemblGenomes-Gn:BSU10180" /db_xref="EnsemblGenomes-Tr:CAB12858" /db_xref="GOA:O07601" /db_xref="InterPro:IPR011397" /db_xref="SubtiList:BG13049" /db_xref="UniProtKB/Swiss-Prot:O07601" /translation="MVSQEAVVFLALSGAIAFLLPIGLIVWFKRKYGASLKVFFIGAL TFFVFAQLLEGGVHVYVLQVNEMTKEAMQHPLWYGIYGCLMAGIFEECGRYLMMRFFM KRHHTWADGLAFGAGHGGLEAILITGLSSISLIVYAFAINSGTFEQLLVNGDVKQALL PIQEQLLHTPSYEWMLGGIERISAIAVQIGLSLLVLYAVKNRRPLFLLYSILLHALFN VPAVLYQRGIIEHAAAVEIIVALIAALSVYWIVKAKRVFQ*" /label="yhfC CDS" gene 1018099..1018875 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /label="yhfC gene" S_feature complement(1018591..1019212) /Source="Nicolas_S_feature" /locus_tag="new_1094366_1094987_c" /HighExp="B36, BT, B60, Pyr, S8, G/S, G135, Mal, M/G, Glucon" /AntisenseName="yhfC" /AntisenseCor="-0.12937903461570099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="0.51248700000000003" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S359" S_feature 1018876..1019247 /Source="Nicolas_S_feature" /locus_tag="new_1094651_1095022" /HighExp="Lbstat, S2, M0t90, M40t90, HiOs, SMMPr, T-2.40H, Etha, Lbtran, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.48518699999999998" /TUshortSig="SigH" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S360" promotor_-10 complement(1019190..1019209) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1019211) /Source="Nicolas_upshifts" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1019223..1019232) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1019225..1019232 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1019247..1019266 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1019249 /Source="Nicolas_upshifts" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="upshifts" CDS 1019288..1020328 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15713475, 15743956; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminopeptidase" /protein_id="NP_388901.1" /db_xref="EnsemblGenomes-Gn:BSU10200" /db_xref="EnsemblGenomes-Tr:CAB12860" /db_xref="GOA:O07603" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13051" /db_xref="UniProtKB/Swiss-Prot:O07603" /translation="MTSVRKTMELIKELVSIPSPTGNTYEVINYIESLLKEWKVETVR NHKGGLIATLPGRDTSRHRMLTAHVDTLGAMVKEIKADGRLKIDLIGGFRYNSIEGEY CQIETASGKMYTGTILMHQTSVHVYKDAGKAERNQENMEIRLDEPVHCRKDTEELGIG VGDFVSFDPRVEITSSGFIKSRHLDDKASVALLLRLIHEIQTEDIELPYTTHFLISNN EEIGYGGNSNIPPETVEYLAVDMGAIGDGQATDEYSVSICVKDASGPYHYQLRKHLVQ LAEKHHIDYKLDIYPYYGSDASAAIKSGHDIVHGLIGPGIDASHAFERTHKSSLRHTA KLLYYYVQSPMV*" /label="yhfE CDS" gene 1019288..1020328 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /label="yhfE gene" CDS 1020341..1020748 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11157739, 14517985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding PUA-containing enzyme" /protein_id="NP_388902.1" /db_xref="EnsemblGenomes-Gn:BSU10210" /db_xref="EnsemblGenomes-Tr:CAB12861" /db_xref="InterPro:IPR007374" /db_xref="InterPro:IPR009326" /db_xref="InterPro:IPR015947" /db_xref="SubtiList:BG13052" /db_xref="UniProtKB/Swiss-Prot:O07604" /translation="MKIYKLKSTFGWEGDDGLGEQLIQQILAGEKSATCAPKSLYSKD ELRDVYQTAGQLVTVYDKHDNPRCNIKVTDVFETTFGAPDMRLVKGEGNGDRIEEFQE DHRMAWAELIKSGELELNEDTVLITELFVLVKD*" /label="yhfF CDS" gene 1020341..1020748 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /label="yhfF gene" downshifts 1020719 /Source="Nicolas_upshifts" /id="D554" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="0.87656" /MaxDrop="5.21108" /score="22.0862441" /energy="-20.3" /TU="U822" /idTUdmin="U822" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(1020785..1022074) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/sodium-glutamate (aspartate) symport permease" /protein_id="NP_388903.1" /db_xref="EnsemblGenomes-Gn:BSU10220" /db_xref="EnsemblGenomes-Tr:CAB12862" /db_xref="GOA:O07605" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12595" /db_xref="UniProtKB/Swiss-Prot:O07605" /translation="MKRIKFGLATQIFVGLILGVIVGVIWYGNPALPTYLQPIGDLFL RLIKMIVIPIVVSSLIIGVAGAGNGKQVGKLGFRTILYFEIITTFAIILGLALANIFH PGTGVNIHEAQKSDISQYVETEKEQSNKSVAETFLHIVPTNFFQSLVEGDLLAIICFT VLFALGISAIGERGKPVLAFFEGVSHAMFHVVNLVMKVAPFGVFALIGVTVSKFGLGS LISLGKLVGLVYVALAFFLIVIFGIVAKIAGISIFKFLAYMKDEILLAFSTSSSETVL PRIMEKMEKIGCPKGIVSFVIPIGYTFNLDGSVLYQSIAALFLAQVYGIDLTIWHQIT LVLVLMVTSKGMAAVPGTSFVVLLATLGTIGVPAEGLAFIAGVDRIMDMARTVVNLTG NALAAVVMSKWEGMFNPAKAETVMSQSKTEQNATISG*" /label="gltT CDS" gene complement(1020785..1022074) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /label="gltT gene" downshifts complement(1020815) /Source="Nicolas_upshifts" /id="D555" /incds=0 /nref=226 /ntot=280 /MaxReadThrough="2.99263" /MaxDrop="7.79183" /score="48.7726082" /energy="-21.9" /TU="U823" /idTUdmin="U824" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature complement(1022075..1022175) /Source="Nicolas_S_feature" /locus_tag="new_1097850_1097950_c" /HighExp="C90, LoTm, LBGexp, Cold, UNK1, BC, dia5, Lbexp, S1, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S361" promotor_-10 complement(1022174..1022193) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1022175) /Source="Nicolas_upshifts" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1022177..1022313) /Source="Nicolas_S_feature" /locus_tag="new_1097952_1098088_c" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, T2.30H, T5.0H, Cold, T2.0H, S0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S362" promotor_-35 complement(1022208..1022214) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1022345..1022485) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388904.1" /db_xref="EnsemblGenomes-Gn:BSU10230" /db_xref="EnsemblGenomes-Tr:CAB12863" /db_xref="InterPro:IPR025432" /db_xref="SubtiList:BG13053" /db_xref="UniProtKB/Swiss-Prot:O07606" /translation="MVMLGKITEFFRNLPSKKCAECGKKIEEQHECYGNICNDCIKVN DL*" /label="yhfH CDS" gene complement(1022345..1022485) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /label="yhfH gene" downshifts complement(1022358) /Source="Nicolas_upshifts" /id="D556" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.70702" /MaxDrop="4.73949" /score="28.7665297" /energy="-13.6" /TU="U824" /idTUdmin="U824" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1022504..1022523) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1022523) /Source="Nicolas_upshifts" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1022536..1022543) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1022567..1022573 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1022587..1022606 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1022590 /Source="Nicolas_upshifts" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="upshifts" CDS 1022637..1023371 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388905.1" /db_xref="EnsemblGenomes-Gn:BSU10240" /db_xref="EnsemblGenomes-Tr:CAB12864" /db_xref="GOA:O07607" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13054" /db_xref="UniProtKB/Swiss-Prot:O07607" /translation="MKVTVIGCYGGFPAANEATSGYLFQSGDYSLLVDCGSAVLSKLF GYVPAEKLDAVVLSHYHHDHIADIGPLQFAKQVGSFLGKGEHTLPIYGHDADIEQFQK LTYKTHTKGIAYQPDQPLTAGPFTITFLKTIHPVTCYAMRITDGSHTVVYTADSSYQD SFIPFSKDADLLISECNFYADQDGTSAGHMNSLEAGRIAKEAGAGELLLTHLPHFGVH DNLRKEAKTVFNGEVNIAKSGFVWEG*" /label="yhfI CDS" gene 1022637..1023371 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /label="yhfI gene" CDS 1023384..1024379 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /EC_number="6.3.1.20" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoate-protein ligase" /protein_id="NP_388906.1" /db_xref="EnsemblGenomes-Gn:BSU10250" /db_xref="EnsemblGenomes-Tr:CAB12865" /db_xref="GOA:O07608" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004562" /db_xref="InterPro:IPR019491" /db_xref="SubtiList:BG13055" /db_xref="UniProtKB/Swiss-Prot:O07608" /translation="MLFIDNQNINDPRINLAIEEYCVKHLDPEQQYLLFYVNQPSIII GKNQNTIEEINTKYVEENGIIVVRRLSGGGAVYHDLGNLNFSFITKDDGDSFHNFKKF TEPVIQALHQLGVEAELSGRNDIVVDGRKISGNAQFATKGRIFSHGTLMFDSAIDHVV SALKVKKDKIESKGIKSIRSRVANISEFLDDKMTTEEFRSHLLRHIFNTNDVGNVPEY KLTEKDWETIHQISKERYQNWDWNYGRSPKFNLNHSKRYPVGSIDLHLEVKKGKIEDC KIFGDFFGVGDVSEIENLLVGKQYERSVIADVLEGVNLKHYFGNITKEDFLDLIY*" /label="lplJ CDS" gene 1023384..1024379 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /label="lplJ gene" CDS 1024444..1025088 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11790741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-binding epimerase / hydratase" /protein_id="NP_388907.1" /db_xref="EnsemblGenomes-Gn:BSU10260" /db_xref="EnsemblGenomes-Tr:CAB12866" /db_xref="GOA:O07609" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13056" /db_xref="UniProtKB/Swiss-Prot:O07609" /translation="MKVFLIGANGQIGQRLVSLFQDNPDHSIRAMVRKEEQKASLEAA GAEAVLANLEGSPEEIAAAAKGCDAIIFTAGSGGSTGYDKTLLVDLDGAAKAIEAAAI AGIKRFIMVSALQAHNRENWNEALKPYYVAKHYADKILEASGLTYTIIRPGGLRNEPG TGTVSAAKDLERGFISRDDVAKTVIASLDEKNTENRAFDLTEGDTPIAEALKKL*" /label="yhfK CDS" gene 1024444..1025088 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /label="yhfK gene" downshifts 1025076 /Source="Nicolas_upshifts" /id="D557" /incds=0 /nref=239 /ntot=258 /MaxReadThrough="0.56809" /MaxDrop="6.84076" /score="18.2092404" /energy="-10" /TU="NA" /idTUdmin="U825" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1025116..1025119 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1025134..1025153 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1025141 /Source="Nicolas_upshifts" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="upshifts" CDS 1025205..1026746 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long-chain fatty-acid-CoA ligase (degradative)" /protein_id="NP_388908.2" /db_xref="EnsemblGenomes-Gn:BSU10270" /db_xref="EnsemblGenomes-Tr:CAB12867" /db_xref="GOA:O07610" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020459" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13057" /db_xref="UniProtKB/Swiss-Prot:O07610" /translation="MNLVSKLEETASEKPDSIACRFKDHMMTYQELNEYIQRFADGLQ EAGMEKGDHLALLLGNSPDFIIAFFGALKAGIVVVPINPLYTPTEIGYMLTNGDVKAI VGVSQLLPLYESMHESLPKVELVILCQTGEAEPEAADPEVRMKMTTFAKILRPTSAAK QNQEPVPDDTAVILYTSGTTGKPKGAMLTHQNLYSNANDVAGYLGMDERDNVVCALPM FHVFCLTVCMNAPLMSGATVLIEPQFSPASVFKLVKQQQATIFAGVPTMYNYLFQHEN GKKDDFSSIRLCISGGASMPVALLTAFEEKFGVTILEGYGLSEASPVTCFNPFDRGRK PGSIGTSILHVENKVVDPLGRELPAHQVGELIVKGPNVMKGYYKMPMETEHALKDGWL YTGDLARRDEDGYFYIVDRKKDMIIVGGYNVYPREVEEVLYSHPDVKEAVVIGVPDPQ SGEAVKGYVVPKRSGVTEEDIMQHCEKHLAKYKRPAAITFLDDIPKNATGKMLRRALR DILPQ*" /label="lcfB CDS" gene 1025205..1026746 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /label="lcfB gene" downshifts 1026726 /Source="Nicolas_upshifts" /id="D558" /incds=0 /nref=5 /ntot=108 /MaxReadThrough="2.74134" /MaxDrop="3.72638" /score="15.3712924" /energy="-10.4" /TU="NA" /idTUdmin="U826" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1026785..1027180) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388909.1" /db_xref="EnsemblGenomes-Gn:BSU10280" /db_xref="EnsemblGenomes-Tr:CAB12868" /db_xref="SubtiList:BG13058" /db_xref="UniProtKB/Swiss-Prot:O07611" /translation="MKKIVAAIVVIGLVFIAFFYLYSRSGDVYQSVDADLITLSSSGQ EDIEIEKRQHVKDMLDIMNQGKQVKTEKTSAPDYEGTIKFHKDRYDSFRLWIDGSQQA VFLKDGTYYKLSKNDTKALLNIIKKEAKD*" /label="yhfM CDS" gene complement(1026785..1027180) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /label="yhfM gene" downshifts complement(1026802) /Source="Nicolas_upshifts" /id="D559" /incds=0 /nref=46 /ntot=89 /MaxReadThrough="0.75539" /MaxDrop="6.88759" /score="17.4775611" /energy="-10.4" /TU="NA" /idTUdmin="U827" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1027200..1027211) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1027204) /Source="Nicolas_upshifts" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1027226..1027232) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1027265..1027268 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1027276 /Source="Nicolas_upshifts" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1027283..1027302 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1027329..1028609 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /EC_number="3.4.24.84" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9015299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane metalloprotease" /protein_id="NP_388910.1" /db_xref="EnsemblGenomes-Gn:BSU10290" /db_xref="EnsemblGenomes-Tr:CAB12869" /db_xref="GOA:P40769" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR027057" /db_xref="InterPro:IPR032456" /db_xref="SubtiList:BG11029" /db_xref="UniProtKB/Swiss-Prot:P40769" /translation="MRKWIAAAGLAYVLYGLFFYWYFFLSGDSAIPEAVKGTQADPAS FMKPSELAVAEQYSNVKNFLFFIGVPLDWFLFFVLLVSGVSKKIKKWIEAAVPFRFLQ TVGFVFVLSLITTLVTLPLDWIGYQVSLDYNISTQTTASWAKDQVISFWISFPIFTLC VLVFYWLIKRHEKKWWLYAWLLTVPFSLFLFFIQPVIIDPLYNDFYPLKNKELESKIL ELADEANIPADHVYEVNMSEKTNALNAYVTGIGANKRIVLWDTTLNKLDDSEILFIMG HEMGHYVMKHVYIGLAGYLLVSLAGFYVIDKLYKRTVRLTRSMFHLEGRHDLAALPLL LLLFSVLSFAVTPFSNAVSRYQENKADQYGIELTENREAAVKTFQDLAVTGLSQVDPP VLVKIFRGSHPSIMERIQHAEKEENAPEHQDADK*" /label="yhfN CDS" gene 1027329..1028609 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /label="yhfN gene" promotor_-10 complement(1027756..1027775) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1027770) /Source="Nicolas_upshifts" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1027791..1027796) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1028596 /Source="Nicolas_upshifts" /id="D560" /incds=0 /nref=2 /ntot=57 /MaxReadThrough="3.82026" /MaxDrop="3.6342" /score="6.45541384" /energy="-12.7" /TU="U828" /idTUdmin="U828" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts complement(1028646) /Source="Nicolas_upshifts" /id="D561" /incds=0 /nref=129 /ntot=219 /MaxReadThrough="-0.11848" /MaxDrop="9.02627" /score="-6.76069514" /energy="-7.8" /TU="NA" /idTUdmin="U830" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(1028648..1029793) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /EC_number="3.4.21.62" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine alkaline protease (Ca(2+)-dependent subtilisin E)" /protein_id="NP_388911.2" /db_xref="EnsemblGenomes-Gn:BSU10300" /db_xref="EnsemblGenomes-Tr:CAB12870" /db_xref="GOA:P04189" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="PDB:1SCJ" /db_xref="PDB:3WHI" /db_xref="SubtiList:BG10190" /db_xref="UniProtKB/Swiss-Prot:P04189" /translation="MRSKKLWISLLFALTLIFTMAFSNMSAQAAGKSSTEKKYIVGFK QTMSAMSSAKKKDVISEKGGKVQKQFKYVNAAAATLDEKAVKELKKDPSVAYVEEDHI AHEYAQSVPYGISQIKAPALHSQGYTGSNVKVAVIDSGIDSSHPDLNVRGGASFVPSE TNPYQDGSSHGTHVAGTIAALNNSIGVLGVAPSASLYAVKVLDSTGSGQYSWIINGIE WAISNNMDVINMSLGGPTGSTALKTVVDKAVSSGIVVAAAAGNEGSSGSTSTVGYPAK YPSTIAVGAVNSSNQRASFSSAGSELDVMAPGVSIQSTLPGGTYGAYNGTSMATPHVA GAAALILSKHPTWTNAQVRDRLESTATYLGNSFYYGKGLINVQAAAQ*" /label="aprE CDS" gene complement(1028648..1029793) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /label="aprE gene" S_feature complement(1029794..1029860) /Source="Nicolas_S_feature" /locus_tag="new_1105569_1105635_c" /HighExp="BC, T5.0H, LoTm, Sw, T4.0H, T3.30H, S1, T3.0H, S2, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S363" promotor_-10 complement(1029849..1029868) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1029866) /Source="Nicolas_upshifts" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1029884..1029888) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1030173..1030180 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-35" promotor_-10 1030195..1030214 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-10" upshifts 1030197 /Source="Nicolas_upshifts" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="upshifts" CDS 1030228..1030677 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /EC_number="2.3.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388912.1" /db_xref="EnsemblGenomes-Gn:BSU10310" /db_xref="EnsemblGenomes-Tr:CAB12871" /db_xref="GOA:O07614" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13059" /db_xref="UniProtKB/Swiss-Prot:O07614" /translation="MNIRQAKTSDAAAIAPLFNQYREFYRQASDLQGAEAFLKARLEN HESVILIAEENGEFIGFTQLYPTFSSVSMKRIYILNDLFVVPHARTKGAGGRLLSAAK DYAGQNGAKCLTLQTEHHNRKARSLYEQNGYEEDTGFVHYCLNVPAK*" /label="yhfO CDS" gene 1030228..1030677 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /label="yhfO gene" promotor_-35 1030693..1030700 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1030715..1030734 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1030722 /Source="Nicolas_upshifts" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1030749..1031741 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9643546, 12057962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388913.1" /db_xref="EnsemblGenomes-Gn:BSU10320" /db_xref="EnsemblGenomes-Tr:CAB12872" /db_xref="GOA:O07615" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014188" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="PDB:1TT7" /db_xref="PDB:1Y9E" /db_xref="SubtiList:BG13060" /db_xref="UniProtKB/Swiss-Prot:O07615" /translation="MSTLFQALQAEKNADDVSVHVKTISTEDLPKDGVLIKVAYSGIN YKDGLAGKAGGNIVREYPLILGIDAAGTVVSSNDPRFAEGDEVIATSYELGVSRDGGL SEYASVPGDWLVPLPQNLSLKEAMVYGTAGFTAALSVHRLEQNGLSPEKGSVLVTGAT GGVGGIAVSMLNKRGYDVVASTGNREAADYLKQLGASEVISREDVYDGTLKALSKQQW QGAVDPVGGKQLASLLSKIQYGGSVAVSGLTGGGEVPATVYPFILRGVSLLGIDSVYC PMDVRAAVWERMSSDLKPDQLLTIVDREVSLEETPGALKDILQNRIQGRVIVKL*" /label="yhfP CDS" gene 1030749..1031741 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /label="yhfP gene" downshifts 1031742 /Source="Nicolas_upshifts" /id="D562" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="4.4421" /MaxDrop="2.9095" /score="14.183693" /energy="-15.3" /TU="U831,U832" /idTUdmin="U831" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" S_feature 1031787..1031897 /Source="Nicolas_S_feature" /locus_tag="new_1107562_1107672" /HighExp="Etha, dia15, LoTm, Salt, H2O2, LBGexp, Diami, Paraq, dia5, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S364" promotor_-35 1031875..1031882 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1031898..1031917 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1031899 /Source="Nicolas_upshifts" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1031958..1032929 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16672620, 20147287; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III) siderophore-binding lipoprotein" /protein_id="NP_388914.2" /db_xref="EnsemblGenomes-Gn:BSU10330" /db_xref="EnsemblGenomes-Tr:CAB12873" /db_xref="GOA:C0SP94" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG13061" /db_xref="UniProtKB/Swiss-Prot:C0SP94" /translation="MKKTLIILTVLLLSVLTAACSSSSGNQNSKEHKVAVTHDLGKTN VPEHPKRVVVLELGFIDTLLDLGITPVGVADDNKAKQLINKDVLKKIDGYTSVGTRSQ PSMEKIASLKPDLIIADTTRHKKVYDQLKKIAPTIALNNLNADYQDTIDASLTIAKAV GKEKEMEKKLTAHEEKLSETKQKISANSQSVLLIGNTNDTIMARDENFFTSRLLTQVG YRYAISTSGNSDSSNGGDSVNMKMTLEQLLKTDPDVIILMTGKTDDLDADGKRPIEKN VLWKKLKAVKNGHVYHVDRAVWSLRRSVDGANAILDELQKEMPAAKK*" /label="yhfQ CDS" gene 1031958..1032929 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /label="yhfQ gene" downshifts 1032908 /Source="Nicolas_upshifts" /id="D563" /incds=0 /nref=172 /ntot=251 /MaxReadThrough="2.22013" /MaxDrop="5.6726" /score="27.9181244" /energy="-10.9" /TU="NA" /idTUdmin="U833" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1032961..1033542) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10869096, 11827481, 12870714, 17693564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869096, 11827481, 12870714, 17693564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase; putative (phosphoglycerate) mutase" /protein_id="NP_388915.1" /db_xref="EnsemblGenomes-Gn:BSU10340" /db_xref="EnsemblGenomes-Tr:CAB12874" /db_xref="GOA:O07617" /db_xref="InterPro:IPR001345" /db_xref="InterPro:IPR013078" /db_xref="InterPro:IPR029033" /db_xref="SubtiList:BG13062" /db_xref="UniProtKB/Swiss-Prot:O07617" /translation="MTAVCLVRHGETDWNLQQKCQGKTDIPLNATGERQARETGEYVK DFSWDIIVTSPLKRAKRTAEIINEYLHLPIVEMDDFKERDYGDAEGMPLEERTKRYPD NIYPNMETLEELTDRLMGGLAKVNQAYPNKKVLIVAHGAAIHALLTEISGGDPELQST RLVNACLSNIEFAEEKWRIKDYNINSHLSGFIK*" /label="phoE CDS" gene complement(1032961..1033542) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /label="phoE gene" downshifts complement(1032984) /Source="Nicolas_upshifts" /id="D564" /incds=0 /nref=218 /ntot=256 /MaxReadThrough="1.23197" /MaxDrop="6.359" /score="28.9228703" /energy="-10.9" /TU="NA" /idTUdmin="U834" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1033566..1033585) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1033578) /Source="Nicolas_upshifts" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1033601..1033604) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1033613..1034707) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /EC_number="2.3.1.9" /experiment="publication(s) with functional evidences, PMID:12368242, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acetyltransferase" /protein_id="NP_388916.1" /db_xref="EnsemblGenomes-Gn:BSU10350" /db_xref="EnsemblGenomes-Tr:CAB12875" /db_xref="GOA:O07618" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG13063" /db_xref="UniProtKB/Swiss-Prot:O07618" /translation="MNAVIVDAKRTIFGNQNGLLKPFLPEDLAAPIIRCLSRKLEDQV DEVILGNATGRGGNLARLSALQAGLPLSVPGMTIDRQCGSGLEAVRYACSLIQAGAGT MYIAGGSESSSQSPFSERARFSPDAIGDPDMGIAAEYTAARYSISRSMQDEYALLSHQ RSRNAHDEGFYREEVVALGELETDEAFLKTRPIEAIIPRAKPVFDTSSGTVTAANSSG IADGAAALLVMEEEKAAALGLKPVLRFIGSAVSGIHPNFPPAAPVVAIRQLLHTHDVT PDDIDLFEINEAFAVKICVCSQELGIPFSKINVRGGALALGHPYGASGAALVTRLFYE AKRRPDCQYAVAAIGSGGGIGLALLFEVLA*" /label="yhfS CDS" gene complement(1033613..1034707) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /label="yhfS gene" CDS complement(1034704..1036143) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12368242, 28032445, 28414710; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative long-chain fatty-acid-CoA ligase (proofreading for biotin synthesis)" /protein_id="NP_388917.1" /db_xref="EnsemblGenomes-Gn:BSU10360" /db_xref="EnsemblGenomes-Tr:CAB12876" /db_xref="GOA:O07619" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13064" /db_xref="UniProtKB/Swiss-Prot:O07619" /translation="MTITHTYSSTAETSPGRVAIQTESEQITYHDWDRLVSQTANWLR SQPSMPNRVAILLPNSLAFLQLFAGAAAAGCTAIPIDTRWSPAECKERLSISNADLVV TLAFFKNKLTDSQTPVVLLDNCMADISEAAADPLPTIDPEHPFYMGFTSGSTGKPKAF TRSHRSWMESFTCTETDFSISSDDKVLIPGALMSSHFLYGAVSTLFLGGTVCLLKKFS PAKAKEWLCRESISVLYTVPTMTDALARIEGFPDSPVKIISSGADWPAESKKKLAAAW PHLKLYDFYGTSELSFVTFSSPEDSKRKPHSAGRPFHNVRIEIRNAGGERCQPGEIGK IFVKSPMRFSGYVNGSTPDEWMTVDDMGYVDEEGFLYISGRENGMIVYGGLNIFPEEI ERVLLACPEVESAAVVGIPDEYWGEIAVAVILGNANARTLKAWCKQKLASYKIPKKWV FADSLPETSSGKIARSRVKKWLEESVQYK*" /label="yhfT CDS" gene complement(1034704..1036143) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /label="yhfT gene" CDS complement(1036150..1036710) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12368242, 15849754, 16850406, 18931129, 23709504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="biotin transporter" /protein_id="NP_388918.1" /db_xref="EnsemblGenomes-Gn:BSU10370" /db_xref="EnsemblGenomes-Tr:CAB12877" /db_xref="GOA:O07620" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13065" /db_xref="UniProtKB/Swiss-Prot:O07620" /translation="MLKLIDMMHIAIFTALMAVLGFMPPLFLSFTPVPITLQTLGVML AGSILRPKSAFLSQLVFLLLVAFGAPLLPGGRGGFGVFFGPSAGFLIAYPLASWLISL AANRLRKVTVLRLFFTHIVFGIIFIYLLGIPVQAFIMHIDLSQAAFMSLAYVPGDLIK AAVSAFLAIKITQALSLSDTMFTKGG*" /label="bioY CDS" gene complement(1036150..1036710) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /label="bioY gene" misc_feature complement(1036160..1036179) /Source="Nicolas_upshift_promotors" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1036174) /Source="Nicolas_upshifts" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1036735..1036754) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1036749) /Source="Nicolas_upshifts" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1036769..1036776) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1036845..1038143) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="heme-based dioxygen sensor" /protein_id="NP_388919.1" /db_xref="EnsemblGenomes-Gn:BSU10380" /db_xref="EnsemblGenomes-Tr:CAB12878" /db_xref="GOA:O07621" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR009050" /db_xref="PDB:1OR4" /db_xref="PDB:1OR6" /db_xref="SubtiList:BG13066" /db_xref="UniProtKB/Swiss-Prot:O07621" /translation="MLFKKDRKQETAYFSDSNGQQKNRIQLTNKHADVKKQLKMVRLG DAELYVLEQLQPLIQENIVNIVDAFYKNLDHESSLMDIINDHSSVDRLKQTLKRHIQE MFAGVIDDEFIEKRNRIASIHLRIGLLPKWYMGAFQELLLSMIDIYEASITNQQELLK AIKATTKILNLEQQLVLEAFQSEYNQTRDEQEEKKNLLHQKIQETSGSIANLFSETSR SVQELVDKSEGISQASKAGTVTSSTVEEKSIGGKKELEVQQKQMNKIDTSLVQIEKEM VKLDEIAQQIEKIFGIVTGIAEQTNLLSLNASIESARAGEHGKGFAVVANEVRKLSED TKKTVSTVSELVNNTNTQINIVSKHIKDVNELVSESKEKMTQINRLFDEIVHSMKISK EQSGKIDVDLQAFLGGLQEVSRAVSHVAASVDSLVILTEE*" /label="hemAT CDS" gene complement(1036845..1038143) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /label="hemAT gene" downshifts complement(1036856) /Source="Nicolas_upshifts" /id="D565" /incds=0 /nref=209 /ntot=243 /MaxReadThrough="2.70691" /MaxDrop="6.97357" /score="5.86442746" /energy="-6.9" /TU="NA" /idTUdmin="U837" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1038197..1038215) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1038200) /Source="Nicolas_upshifts" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1038229..1038235) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1038282..1039811) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with Rieske [2Fe-2S] center" /protein_id="NP_388920.1" /db_xref="EnsemblGenomes-Gn:BSU10390" /db_xref="EnsemblGenomes-Tr:CAB12879" /db_xref="GOA:O07622" /db_xref="InterPro:IPR005805" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG13067" /db_xref="UniProtKB/Swiss-Prot:O07622" /translation="MANQHFAKEAPETYWKTSTDLPSFPALQEDTECDVTIIGGGITG ITTAYELTKRGFRVVLIEANQVLNGTTAHTTAKVTAQHDMIYDEFIRHFGLNHARLYY EANQNAIDYIKGIVDEHQIDCEWIEQDAYLYTANENAVQKIHTEHEAYTKLGIERDLI KDLPIPLGSKLALVMKNQAQFHPLQYLKALLEQIVQKGGRIYEETVALDIKKGERPEV VTKSRHAIKSRFIICCSHFPFYDGGGLYAARMYSDRSYVLAIKPKIEYPEGMYLSIDQ PSVALRYTVVNGEKLILFSGVSHKTGQGKAMSTHYETLRQLAESTIGIESIPYYWSTQ DLVTIDKIPFIGPMSENEDNILVATGFKKWGMTSSAVAATLLSDLVEKKENPYESIFT PSRFHLNPGLQKVISYNADVAKHLIKGKLEKPDVQFEDISPGEGKAVTINGRRAGAFR DETGCLHLVDTTCTHLGCEVEWNDSEHTWDCPCHGSRFKPSGEVVEGPAIKPLKQIDL D*" /label="yhfW CDS" gene complement(1038282..1039811) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /label="yhfW gene" promotor_-10 complement(1039838..1039856) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1039848) /Source="Nicolas_upshifts" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1039867..1039872 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1039871..1039876) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1039884 /Source="Nicolas_upshifts" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1039888..1039906 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1039923..1040780 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18643936, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388921.1" /db_xref="EnsemblGenomes-Gn:BSU10400" /db_xref="EnsemblGenomes-Tr:CAB12880" /db_xref="GOA:P40397" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11058" /db_xref="UniProtKB/Swiss-Prot:P40397" /translation="MANQKKKTLPPQHQNQQPGFEYLMDPRPVFDKPKKAKKLEGKTA IITGGDSGIGRAVSVLFAKEGANVVIVYLNEHQDAEETKQYVEKEGVKCLLIAGDVGD EAFCNDVVGQASQVFPSIDILVNNAAEQHVQPSIEKITSHQLIRTFQTNIFSMFYLTK AVLPHLKKGSSIINTASITAYKGNKTLIDYSATKGAIVTFTRSLSQSLVQQGIRVNAV APGPIWTPLIPASFAAKDVEVFGSDVPMERPGQPVEVAPSYLYLASDDSTYVTGQTIH VNGGTIVNG*" /label="yhxC CDS" gene 1039923..1040780 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /label="yhxC gene" downshifts 1040762 /Source="Nicolas_upshifts" /id="D566" /incds=0 /nref=10 /ntot=36 /MaxReadThrough="2.65833" /MaxDrop="4.80135" /score="-8.69335909" /energy="-4.5" /TU="NA" /idTUdmin="U839" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1040808..1041041) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388922.1" /db_xref="EnsemblGenomes-Gn:BSU10410" /db_xref="EnsemblGenomes-Tr:CAB12881" /db_xref="InterPro:IPR014957" /db_xref="SubtiList:BG13087" /db_xref="UniProtKB/Swiss-Prot:O31594" /translation="MKEKKSYTELMKSRNTQKTKEFDVTMTDIYIQMVLDESLYNRRL AMLTDQINKALDEKDKDAFLTLSKEYAALKQSE*" /label="yhzC CDS" gene complement(1040808..1041041) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /label="yhzC gene" downshifts complement(1040841) /Source="Nicolas_upshifts" /id="D567" /incds=0 /nref=191 /ntot=247 /MaxReadThrough="3.34616" /MaxDrop="7.00218" /score="21.4902337" /energy="-12.3" /TU="U841" /idTUdmin="U844" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1041058..1041077) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1041061..1041062 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1041061 /Source="Nicolas_upshifts" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1041065..1041080 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1041080) /Source="Nicolas_upshifts" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1041082..1041937) /Source="Nicolas_S_feature" /locus_tag="new_1116857_1117712_c" /HighExp="Salt, Etha, C30, Heat, S8, LPhT, Gly, C90, S7, UNK1" /AntisenseName="comK" /AntisenseCor="-5.68778941053006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S365" promotor_-35 complement(1041092..1041099) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1041264..1041271 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-35" promotor_-10 1041283..1041302 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-10" upshifts 1041289 /Source="Nicolas_upshifts" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="upshifts" CDS 1041334..1041912 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence transcription factor (CTF)" /protein_id="NP_388923.1" /db_xref="EnsemblGenomes-Gn:BSU10420" /db_xref="EnsemblGenomes-Tr:CAB12882" /db_xref="GOA:P40396" /db_xref="InterPro:IPR010461" /db_xref="SubtiList:BG11059" /db_xref="UniProtKB/Swiss-Prot:P40396" /translation="MSQKTDAPLESYEVNGATIAVLPEEIDGKICSKIIEKDCVFYVN MKPLQIVDRSCRFFGSSYAGRKAGTYEVTKISHKPPIMVDPSNQIFLFPTLSSTRPQC GWISHVHVKEFKATEFDDTEVTFSNGKTMELPISYNSFENQVYRTAWLRTKFQDRIDH RVPKRQEFMLYPKEERTKMIYDFILRELGERY*" /label="comK CDS" gene 1041334..1041912 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /label="comK gene" S_feature 1041913..1042058 /Source="Nicolas_S_feature" /locus_tag="new_1117688_1117833" /HighExp="GM 150, C30, T-4.40H, T-3.40H, GM 120, M9-tran, T-2.40H, C90, G/S, T-1.10H" /AntisenseName="yhxD" /AntisenseCor="-0.229484184862048" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S366" CDS complement(1041959..1042858) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388924.1" /db_xref="EnsemblGenomes-Gn:BSU10430" /db_xref="EnsemblGenomes-Tr:CAB12883" /db_xref="GOA:P40398" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11060" /db_xref="UniProtKB/Swiss-Prot:P40398" /translation="MSDSNLTNPIKAFFHDEFPEQYQEPPGLQKNMKPVPDCGEKSYK GSGKLTGRKALVTGGDSGIGRAAAIAYAREGADVAINYLPEEQPDAEEVKELIEAEGR KAVLIPGDLSDESFCQDLVKQSHHELGGLDVLALVAGKQQAVENIEDLPTEQIYKTFE VNVFSLYWVVKAALPYLPEGASIITTTSVEGYNPSPMLLDYAATKNAIIGFTVGLGKQ LASKGIRVNSVAPGPIWTPLQISGGQPTENIPKFGQGTPPAPLNRAGQPVELADVYVF LASENSSYVTSQVYGITGGIPTA*" /label="yhxD CDS" gene complement(1041959..1042858) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /label="yhxD gene" downshifts complement(1041982) /Source="Nicolas_upshifts" /id="D568" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="4.95535" /MaxDrop="4.1467" /score="-2.68458203" /energy="-14.6" /TU="U844" /idTUdmin="U844" /TUdmin="-1144" /isTUend="FALSE" /label="downshifts" promotor_-35 1042045..1042048 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1042060 /Source="Nicolas_upshifts" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1042066..1042070 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1042104 /Source="Nicolas_upshifts" /id="D569" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="5.45904" /MaxDrop="5.6543" /score="-8.69335909" /energy="-4.5" /TU="U842" /idTUdmin="U843" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1042149..1043015 /Source="Nicolas_S_feature" /locus_tag="new_1117924_1118790" /HighExp="GM 150, C30, T-4.40H, C90, T-3.40H, T-2.40H, G/S, T-5.40H, M9-tran, nit" /AntisenseName="yhxD" /AntisenseCor="-0.32746434250834699" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S367" promotor_-10 complement(1042885..1042903) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1042902) /Source="Nicolas_upshifts" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1042918..1042924) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1042992..1042999 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1043014..1043033 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1043017 /Source="Nicolas_upshifts" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="upshifts" CDS 1043075..1043344 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388925.1" /db_xref="EnsemblGenomes-Gn:BSU10440" /db_xref="EnsemblGenomes-Tr:CAB12884" /db_xref="InterPro:IPR008613" /db_xref="SubtiList:BG13068" /db_xref="UniProtKB/Swiss-Prot:O07555" /translation="MKKAAAVLLSLGLVFGFSYGAGHVAEAKTKVKVYKNCKELNKVY KGGVARTSKVKNKGGKTKYKPYVSKALYDANKNKDRDKDLIACER*" /label="yhjA CDS" gene 1043075..1043344 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /label="yhjA gene" downshifts 1043336 /Source="Nicolas_upshifts" /id="D570" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.67325" /MaxDrop="7.59695" /score="27.4895724" /energy="-11.2" /TU="NA" /idTUdmin="U845" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1043384) /Source="Nicolas_upshifts" /id="D571" /incds=0 /nref=11 /ntot=113 /MaxReadThrough="2.40747" /MaxDrop="4.60953" /score="20.2036192" /energy="-11.2" /TU="NA" /idTUdmin="U846" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(1043387..1044856) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite cotransporter" /protein_id="NP_388926.1" /db_xref="EnsemblGenomes-Gn:BSU10450" /db_xref="EnsemblGenomes-Tr:CAB12885" /db_xref="GOA:O07556" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13069" /db_xref="UniProtKB/Swiss-Prot:O07556" /translation="MNAALIIIFGVLLLSIFLGIRAQKGKDMNLEQWTVGGRGFGTVF VFLLMAGEIYTTFTFLGGSGWAYGKGGPAFYIIAYGCLAYILSYWLLPAVWTYAKQHK LMSQSDFFTKKYNSPLLGILVSLVGIAALIPYLVLQLKGLGLIVSETSYGKITPTAAI WIGAVSITVYVMVSGIHGSAWISVVKDIMILVVVLFLGVYLPIHYYGGFQDMFQQIET AKPGFLTLPESGQSVAWFSSTVLLTALGFYMWPHTFSASYSAENPKVFRKNAIIMPLY QLVLLFVLFVGFAAILQVPDLNGADGDLSLLRLSLQAFDPWFVGIIGAAGLLTALVPG SMILMSASTLFAKNVYKVIAPRTTEQQVSALAKFLVPVIALISVYFTFKGGNTIVTLL LMGYSLVTQLFPALLFSLLKHNMVTKQGAFAGIIAGVGAVTYITMTETTIGTLFPALP QAAKDLNVGIVALLLNITVMMAVSLMTRKAKSAAADQAA*" /label="yhjB CDS" gene complement(1043387..1044856) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /label="yhjB gene" CDS complement(1044853..1045053) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388927.1" /db_xref="EnsemblGenomes-Gn:BSU10460" /db_xref="EnsemblGenomes-Tr:CAB12886" /db_xref="GOA:O07557" /db_xref="InterPro:IPR021741" /db_xref="SubtiList:BG13070" /db_xref="UniProtKB/Swiss-Prot:O07557" /translation="MKLIHVLAALPFIGILLGIPFANKVTPYVFGMPFILAYIVMWAL LTSALMAIVYVLDKENKKEEAE*" /label="yhjC CDS" gene complement(1044853..1045053) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /label="yhjC gene" S_feature complement(1045054..1045172) /Source="Nicolas_S_feature" /locus_tag="new_1120829_1120947_c" /HighExp="S1, Etha, HiOs, MG 120, LoTm, T-5.40H, S2, GM-0.1, GM-0.2, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S368" promotor_-10 complement(1045155..1045174) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1045172) /Source="Nicolas_upshifts" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1045187..1045194) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1045260) /Source="Nicolas_upshifts" /id="D572" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.99656" /MaxDrop="2.67326" /score="20.2036192" /energy="-11.2" /TU="U848" /idTUdmin="U848" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(1045261..1045623) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388928.1" /db_xref="EnsemblGenomes-Gn:BSU10470" /db_xref="EnsemblGenomes-Tr:CAB12887" /db_xref="GOA:O07558" /db_xref="SubtiList:BG13071" /db_xref="UniProtKB/Swiss-Prot:O07558" /translation="MPNLQEEIYDLIERALFLPMAITIFNRDLAGIEESTLKLKHPYK QLISESLKIAQKDLMEVRKELRKRKIAIRETERDEAFTLYTFVIDGYEENHRYFNPRI REQVSELLTYYLFAPDRL*" /label="yhjD CDS" gene complement(1045261..1045623) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /label="yhjD gene" promotor_-35 1045461..1045466 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1045482..1045500 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1045483 /Source="Nicolas_upshifts" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="upshifts" S_feature 1045492..1045731 /Source="Nicolas_S_feature" /locus_tag="new_1121267_1121506" /HighExp="S6, S4, S8, S5, LoTm, B36, S3, S7, BT, B60" /AntisenseName="yhjD" /AntisenseCor="0.24202608585419999" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S369" promotor_-10 complement(1045653..1045672) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1045671) /Source="Nicolas_upshifts" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1045687..1045694) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1045713..1045720 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1045733 /Source="Nicolas_upshifts" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1045734..1045753 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1045775..1046398 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388929.1" /db_xref="EnsemblGenomes-Gn:BSU10480" /db_xref="EnsemblGenomes-Tr:CAB12888" /db_xref="GOA:O07559" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13072" /db_xref="UniProtKB/Swiss-Prot:O07559" /translation="MLEHFLSYLTQEHLTELFQSYRAFGPLIAVLLPLIEAFLPFLPL IVFVVANTNSFGLWEGFILSWAGSTAGSILVFLIVRQYGQRKLLGFIRSHPSVRKLML WVERHGFGPMFLLLCFPFTPSAAVNVVAGLSRIGTRPFILAAASGKLVMIFMISFIGY DLHALITQPIRTVIAVLVITVLWYVGKKVERYLHVRASQREHDGGRQ*" /label="yhjE CDS" gene 1045775..1046398 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /label="yhjE gene" CDS 1046400..1046906 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /EC_number="3.4.21.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9325333, 9694797, 11309398, 12897006, 14568161, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 9694797, 11309398, 12897006, 14568161, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388930.1" /db_xref="EnsemblGenomes-Gn:BSU10490" /db_xref="EnsemblGenomes-Tr:CAB12889" /db_xref="GOA:O07560" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG12674" /db_xref="UniProtKB/Swiss-Prot:O07560" /translation="MKKRFWFLAGVVSVVLAIQVKNAVFIDYKVEGVSMNPTFQEGNE LLVNKFSHRFKTIHRFDIVLFKGPDHKVLIKRVIGLPGETIKYKDDQLYVNGKQVAEP FLKHLKSVSAGSHVTGDFSLKDVTGTSKVPKGKYFVVGDNRIYSFDSRHFGPIREKNI VGVISDAE*" /label="sipV CDS" gene 1046400..1046906 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /label="sipV gene" downshifts 1046899 /Source="Nicolas_upshifts" /id="D573" /incds=0 /nref=131 /ntot=250 /MaxReadThrough="0.63331" /MaxDrop="4.58282" /score="-7.37718733" /energy="-7.1" /TU="NA" /idTUdmin="U847" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1046957..1046964 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1046978..1046997 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1046987..1047086 /Source="Nicolas_S_feature" /locus_tag="new_1122762_1122861" /HighExp="LBGstat, LBGexp, Lbtran, C90, dia0, Lbexp, HPh, dia5, aero, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S370" upshifts 1046987 /Source="Nicolas_upshifts" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="upshifts" CDS 1047087..1048586 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7678243, 15121720; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic compound monooxygenase/hydroxylase" /protein_id="NP_388931.1" /db_xref="EnsemblGenomes-Gn:BSU10500" /db_xref="EnsemblGenomes-Tr:CAB12890" /db_xref="GOA:O07561" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13073" /db_xref="UniProtKB/Swiss-Prot:O07561" /translation="MMMKYEAVIIGGGPVGFMLASELAIAGVGTCVIERLEKPVPHSK ALTLHPRTLELLEMRGILERFVSKGSKIPTGHFSMLDTRLDFSGLDTSCPYTLLLPQS KTEKLLEDHARSLGTEVFRGAEALAVTQNGEAVQTIFKDRDGSVRTITSKFAVGADGA GSTVRKQAKIEFPGTDSTVTAALGDVVLLSPPPSGVLSLCTKEGGVMIVPLSPDRYRV VVISPYRTQTPKDVPVTEEELKADLLRICGTDFGLTDPSWMSRFGNAARQAKRYRDGR IFLAGDAAHIHFPAGGQGLNVGLQDAMNLGWKLAAAIKGSAPSWLLDSYHDERHPAAE GLLRNTEAQTKLIDFTQAGLHLRSMMSELLAFPDVNRYVAGQISALDVRYEADRTMPP NRLNGARLPDMKLILSDGNSERLYSFLQNGTFVLLSLRQEADDHIEVKGLRTVTASLA EPNEKLRNVHTILIRPDGHVAWAVDASAPDCSEVIQKGISRWFSVTSRV*" /label="yhjG CDS" gene 1047087..1048586 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /label="yhjG gene" promotor_-35 1048594..1048601 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1048613 /Source="Nicolas_upshifts" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1048615..1048634 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1048663..1049190 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388932.1" /db_xref="EnsemblGenomes-Gn:BSU10510" /db_xref="EnsemblGenomes-Tr:CAB12891" /db_xref="GOA:Q796S4" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13074" /db_xref="UniProtKB/Swiss-Prot:Q796S4" /translation="MNTDHTKRNLFELYAELIHQQEKWEGLIKAFLSDELRKLDVEHG SKSQLTMTEIHVLSCVGDNEPINVTSIAEKMNTTKATVSRISTKLLGAGFLHRTQLSD NKKEVYFRLTPAGKKLHSLHKYYHQKAEQRFLSFFDRYTEEEILFAERLFRDLVTKWY PSSEEIEGGLPSIFK*" /label="yhjH CDS" gene 1048663..1049190 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /label="yhjH gene" downshifts 1049152 /Source="Nicolas_upshifts" /id="D574" /incds=0 /nref=8 /ntot=128 /MaxReadThrough="1.1509" /MaxDrop="3.41655" /score="11.3050978" /energy="-9.9" /TU="NA" /idTUdmin="U851" /TUdmin=8 /isTUend="TRUE" /label="downshifts" S_feature complement(1049204..>1049224) /Source="Nicolas_S_feature" /locus_tag="new_1124979_1125122_c" /HighExp="B36, B60, T0.30H, LBGstat, T1.30H, T1.0H, LPhT, LBGtran, Diami, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S371" SCAR join(1049224,1049240) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_001" N_region 1049225..1049239 /note="inserted sequence possibly derived from two restrictions with NotI and SacI" /created_by="User" /modified_by="User" /label="IIG_Bs27_001" S_feature <1049240..1049526 /Source="Nicolas_S_feature" /locus_tag="new_1130705_1131082" /HighExp="T4.0H, T5.0H, T3.30H, T2.0H, HiOs, T2.30H, T3.0H, LoTm, T1.30H, Pyr" /AntisenseName="yhjN" /AntisenseCor="-5.0383887616073E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig="0.997" /label="S375" S_feature complement(<1049240..1049361) /Source="Nicolas_S_feature" /locus_tag="new_1130759_1130917_c" /HighExp="B60, Sw, Cold, B36, BI, GM 15, GM 10, C30, GM 25, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S376" downshifts complement(1049246) /Source="Nicolas_upshifts" /id="D577" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="3.07371" /MaxDrop="4.24831" /score="-1.9470655" /energy="-7.1" /TU="U856" /idTUdmin="U856" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(1049362..1050516) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (recentHGT island)" /protein_id="NP_388938.1" /db_xref="EnsemblGenomes-Gn:BSU10570" /db_xref="EnsemblGenomes-Tr:CAB12897" /db_xref="GOA:O07568" /db_xref="InterPro:IPR007820" /db_xref="InterPro:IPR017516" /db_xref="SubtiList:BG13080" /db_xref="UniProtKB/Swiss-Prot:O07568" /translation="MKKDENLLKDLWFIAISAAGGFILSLTGISIGWMIGTLIVACCL AMIRPAWLMMAPDQKGINRRWLALGQMILGIELGQKLNLSVLSVLKDHWFSVGVMLIL SILLAMLSGYVLWRFSKTDMMTSFVGTAPGGLSAMPSIAQEVGANTAIVSLVQMMRVL LVVLSIPFLVILIYTKQDRTASAAAETISSATTDFRLAPVLWTVILILAAWGACKAAK FLKFPAPWLLGSMLGVAIVHVGGAAVTGHDMTAWWLSQANHVSQVFLGATIGSKMYKS MFAGVTRIIIVGFVSSVGLIAAMFLSAVIVSELTGISLITSVLAFAPGGIAEMATTSV TLHADSTFVVAVQVIRVILVIALLPPFYRLLHHLHGEKKDKKSSISGSSA*" /label="yhjN CDS" gene complement(1049362..1050516) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /label="yhjN gene" S_feature complement(1050517..1050588) /Source="Nicolas_S_feature" /locus_tag="new_1132073_1132144_c" /HighExp="Cold, GM 15, GM 10, dia15, BC, BI, Salt, B60, Sw, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S377" promotor_-10 complement(1050571..1050590) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1050587) /Source="Nicolas_upshifts" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1050604..1050609) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1050623..1051828) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease (recent HGT island)" /protein_id="NP_388939.1" /db_xref="EnsemblGenomes-Gn:BSU10580" /db_xref="EnsemblGenomes-Tr:CAB12898" /db_xref="GOA:O07569" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13081" /db_xref="UniProtKB/Swiss-Prot:O07569" /translation="MLTSFHSIKSRYTAPVRLRFFGELLTSLTGAMMGPFMVLYLHEQ LNGSIMMPMLIISLQPFADIFLTLAAGRVTDRLGRRTAILTALLLQSAAMTGFVFAEH AYVFAILYVMNGIGRSLYIPASRAQIAESTPESRRSEVFAVINAIYSTGLTAGPLVGM LLYNHNPVWIFALDAAALFIYFLIAALKLPETKPLHPAVTPKMSASFTIYRPVLLLLL LSLPISMLYAQTETTYRLFSKNMFSDYLSMLTIYSAAKALFSCVLQVPLVKGTEKLSM KTILFITYICYSLAAAGFACSTSLTMLLVTAAVMTVGESIGLTHIQTFISKLAPPHLL GRFYAVYGLHWDISRSIGPLAGGLILTSFGGEVIFYALAVCLLTAGLSLTYTIEKLEH KVIRKVNRL*" /label="yhjO CDS" gene complement(1050623..1051828) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /label="yhjO gene" misc_feature 1051849..1051868 /Source="Nicolas_upshift_promotors" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1051854 /Source="Nicolas_upshifts" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1051942..1053669 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcription factor" /protein_id="NP_388940.1" /db_xref="EnsemblGenomes-Gn:BSU10590" /db_xref="EnsemblGenomes-Tr:CAB12899" /db_xref="GOA:O07570" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR025370" /db_xref="InterPro:IPR030678" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13082" /db_xref="UniProtKB/Swiss-Prot:O07570" /translation="MKLIEHYVALVKTGCAEYGQMNEMTLTEIADCLFCTERNAKLIL HKLENSNWIIRESGAGRGRKSKIAFLRRPEELLLQTAKEYTMSGKLKKAKELLQQYQS AFPGLQNEYNMWLSEVFGFVTETGENGAKDVLRLFITPESVSSLDPCQIFLRSEGHFV KQIFDTLFTFDSDMQEPKPHLVHGWEEVGKKQWRFFLRKGVLFHNGQPLTSRDVAFTF QRFLELADNPYKWLLHGVKQVLEKGPYCVELILDKPNALLPYALCDERLSILPAEQGG GKNGTGPFQMNQQHSGMLVLEANERYFKGRPYLDRVEFVFSEQAGEMNGFTIQEKQTC PEQQTVFDERHVQYLSLNLKKKGPLQHRSFRKALRLLISSERLVREAGGHRRIPVTSF LHPSPFEWEGVSPSELLKKSGYEGETIVLYTFSETDHREDAEWIQNICAQHGIRLTLQ FCDAADLRRPEIVQMADIIHDSATFYQDSEFGFLHLLLSENSFLYQHLSEKLTQICSG MTERMFSMPDRCSRINILRDIDRQMIQELNAIPLYQNVLQVTSSKNVKGLVLDEEGWI DLYSVWLSK*" /label="yhjP CDS" gene 1051942..1053669 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /label="yhjP gene" promotor_-35 1053255..1053262 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1053277..1053296 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1053284 /Source="Nicolas_upshifts" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1053699..1054025) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12625841; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative metal-chelating cysteine-rich protein of unknown function" /protein_id="NP_388941.1" /db_xref="EnsemblGenomes-Gn:BSU10600" /db_xref="EnsemblGenomes-Tr:CAB12900" /db_xref="InterPro:IPR005560" /db_xref="PDB:5FIG" /db_xref="SubtiList:BG13083" /db_xref="UniProtKB/Swiss-Prot:O07571" /translation="MEQYSEACIEACIDCMKACNHCFTKCLEESVQHHLSGCIRLDRE CADICALAVKAMQTDSPFMKEICALCADICEACGTECGKHDHDHCQACAKACFTCAEQ CRSMAA*" /label="yhjQ CDS" gene complement(1053699..1054025) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /label="yhjQ gene" CDS complement(1054143..1054580) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22078549, 22882546; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative electron carrier protein (putative sporulation gene)" /protein_id="NP_388942.1" /db_xref="EnsemblGenomes-Gn:BSU10610" /db_xref="EnsemblGenomes-Tr:CAB12901" /db_xref="GOA:O07572" /db_xref="InterPro:IPR003251" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13084" /db_xref="UniProtKB/Swiss-Prot:O07572" /translation="MHYSYYPYPVPYREDPVLIRNLQKAINGEFSAIQCYRKLAELAH SDEVRKQIEEIRRDEIRHLREFSTLYGSITGKHIMPKQTEECPDNFTRGLDAAFKDEQ ETVDFYLRAAEETSNLKAKGVFTRAARDEQNHAVWFLYYLMER*" /label="yhjR CDS" gene complement(1054143..1054580) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /label="yhjR gene" downshifts complement(1054152) /Source="Nicolas_upshifts" /id="D578" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.72767" /MaxDrop="3.86885" /score="16.2430017" /energy="-11.5" /TU="U859" /idTUdmin="U859" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1054611..1054630) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1054631) /Source="Nicolas_upshifts" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1054643..1054652) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1054700..1054707 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1054721..1054740 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1054733 /Source="Nicolas_upshifts" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="upshifts" CDS 1054764..1058264 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit B)" /protein_id="NP_388943.2" /db_xref="EnsemblGenomes-Gn:BSU10620" /db_xref="EnsemblGenomes-Tr:CAB12902" /db_xref="GOA:P23477" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014140" /db_xref="InterPro:IPR027417" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10465" /db_xref="UniProtKB/Swiss-Prot:P23477" /translation="MGAEFLVGRSGSGKTKLIINSIQDELRRAPFGKPIIFLVPDQMT FLMEYELAKTPDMGGMIRAQVFSFSRLAWRVLQHTGGMSRPFLTSTGVQMLLRKLIEE HKQEFKVYQKASDKSGFTAQVERMLTEFKRYCLEPEDIRRMAESGTASEYRGERVLSE KLHDLSILYQQMEKSLADQYLHSEDYLTLLAEHIPLAEDIKGAHIYVDGFYQFTPQEF RVLEQLMVHAEHITFSLTADKPSYEREPHELELFRMTGKTYYRLHQKAKELNLDITYK ELSGTERHTKTPELAHLEAQYEARPAIPYAEKQEALTVMQAANRRAELEGIAREIHAL VREKGYRYKDVAILARQPEDYKDMVKEVFADYEIPYFIDGKASMLNHPLIEFIRSSLD VLKGNWRYEAVFRCVKTELLFPLNEPKAKVREQVDQLENYCIAYGIKGDRWTKGDRFQ YRRFVSLDDDFAQTDQEIEMENMLNDTRDWIVPPLFQLQKRMKKAKTVQEKAEALYRY LEETDVPLKLDQERQRAEDDGRIIEAQQHQQAWDAVIQLLEEFVEMMGDDEISLDLFQ QMIEAGAESLTFSLIPPALDQVFVGNMDLSRMYGTSCTFVLGANDGVLPARPDENGVL SDDDREWLKTIGVELSSGGRERLLDEHFLIYMAFSSPSDRLYVSYPIADAEGKTLLPS MIVKRLEELFPHHKERLLTNEPEQVSDEEQLMYVVNKSVAQSFTASQLRLWTREYDIS DVWWSTYNVLMSEQDRLQSKKLFSSLFFRNEVKQLERSVSRQLYGERIQGSVSRMETF NACPFSHFASHGLHLKERQFFKLEAPDIGQLFHSSLKLISDRLREQKLDWRDLTKEQC ELFSYDAVERLAPKLQKEILLSSNRHYYVKEKLQKIVTRVSGILSEHAKASGFVPIGL ELGFGGKGPLPPLTFQLKNGCTMELVGRIDRVDKAESSKGLLLRIVDYKSSDKGLDLA EVYYGLALQMLTYLDLSITHSADWLGMRATPAGVLYFHIHDPMIQSNLPLGLDEIEQE IFKKFKMKGLLLGDQEVVRLMDTTLQEGRSNIINAGLKKDGSLRSDSAAVGEKEFDLL TKHVRRTFQEAGEQITDGRVSIEPYKMKNKTPCTYCAFKSVCQFDESLEENEYRPLKA EKDKTILEWIKKEADGNEHS*" /label="addB CDS" gene 1054764..1058264 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /label="addB gene" CDS 1058251..1061949 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit A)" /protein_id="NP_388944.2" /db_xref="EnsemblGenomes-Gn:BSU10630" /db_xref="EnsemblGenomes-Tr:CAB12903" /db_xref="GOA:P23478" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR011335" /db_xref="InterPro:IPR011604" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014152" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10466" /db_xref="UniProtKB/Swiss-Prot:P23478" /translation="MNIPKPADSTWTDDQWNAIVSTGQDILVAAAAGSGKTAVLVERM IRKITAEENPIDVDRLLVVTFTNASAAEMKHRIAEALEKELVQRPGSLHIRRQLSLLN RASISTLHSFCLQVLKKYYYLIDLDPGFRIADQTEGELIGDEVLDELFEDEYAKGEKA FFELVDRYTTDRHDLDLQFLVKQVYEYSRSHPNPEAWLESFVHLYDVSEKSAIEELPF YQYVKEDIAMVLNGAKEKLLRALELTKAPGGPAPRADNFLDDLAQIDELIQHQDDFSE LYKRVPAVSFKRAKAVKGDEFDPALLDEATDLRNGAKKLLEKLKTDYFTRSPEQHLKS LAEMKPVIETLVQLVISYGKRFEAAKQEKSIIDFSDLEHYCLAILTAENDKGEREPSE AARFYQEQFHEVLVDEYQDTNLVQESILQLVTSGPEETGNLFMVGDVKQSIYRFRLAE PLLFLSKYKRFTESGEGTGRKIDLNKNFRSRADILDSTNFLFKQLMGGKIGEVDYDEQ AELKLGAAYPDNDETETELLLIDNAEDTDASEEAEELETVQFEAKAIAKEIRKLISSP FKVYDGKKKTHRNIQYRDIVILLRSMPWAPQIMEELRAQGIPVYANLTSGYFEAVEVA VALSVLKVIDNPYQDIPLASVLRSPIVGADENELSLIRLENKKAPYYEAMKDYLAAGD RSDELYQKLNTFYGHLQKWRAFSKNHSVSELIWEVYRDTKYMDYVGGMPGGKQRQANL RVLYDRARQYESTAFRGLFRFLRFIERMQERGDDLGTARALSEQEDVVRLMTIHSSKG LEFPVVFVAGLGRNFNMMDLNKSYLLDKELGFGTKYIHPQLRISYPTLPLIAMKKKMR RELLSEELRVLYVALTRAKEKLFLIGSCKDHQKQLAKWQASASQTDWLLPEFDRYQAR TYLDFIGPALARHRDLGDLAGVPAHADISGHPARFAVQMIHSYDLLDDDLEERMEEKS ERLEAIRRGEPVPGSFAFDEKAREQLSWTYPHQEVTQIRTKQSVSEIKRKREYEDEYS GRAPVKPADGSILYRRPAFMMKKGLTAAEKGTAMHTVMQHIPLSHVPSIEEAEQTVHR LYEKELLTEEQKDAIDIEEIVQFFHTEIGGQLIGAKWKDREIPFSLALPAKEIYPDAH EADEPLLVQGIIDCLYETEDGLYLLDYKSDRIEGKFQHGFEGAAPILKKRYETQIQLY TKAVEQIAKTKVKGCALYFFDGGHILTL*" /label="addA CDS" gene 1058251..1061949 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /label="addA gene" S_feature 1061950..1062020 /Source="Nicolas_S_feature" /locus_tag="new_1143506_1143576" /HighExp="H2O2, C90, Heat, LBGtran, dia15, HiTm, Diami, C30, Lbtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S378" CDS 1062021..1063196 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7968921, 8493111, 16780573" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7968921, 8493111, 16780573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair exonuclease" /protein_id="NP_388945.3" /db_xref="EnsemblGenomes-Gn:BSU10640" /db_xref="EnsemblGenomes-Tr:CAB12904" /db_xref="GOA:P23479" /db_xref="InterPro:IPR004593" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR026843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG10467" /db_xref="UniProtKB/Swiss-Prot:P23479" /translation="MRILHTADWHLGKTLEGRSRLSEQADVLDELNTIVKDEQIDAIV MAGDAFDTVNPPALAEQLFYESLSALSDRGKRPIVVIAGNHDNPDRLSAASPLTHENG IHLIGYPTTEPIHIEVPSAGELLAVGALAYPSEARLNEVLSDTFDEKLLRDHYDVKIR QAFEHMTSRFRTDAVKIAASHIYVAGGNQTDSERPIEVGGAYTVAAESLPADAAYVAL GHLHRPQTIKRARTLARYSGSPLAYSFSEAGYAKSVTIVDAKPGEEATWQEVLLSSGK PLVKWKAANGLSEVYSWLDEGRDQNAWIDLEIRVADQLSLEEIHRLRKAHPGFIHIRP VFEEQNKDRERIEVKHVSIEDRFKKFYEKQTGGAVPDEEMVKLFLELASGVEEEDAK* " /label="sbcD CDS" gene 1062021..1063196 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /label="sbcD gene" CDS 1063193..1066585 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 19906728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 19906728; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ATP-dependent repair enzyme" /protein_id="NP_388946.2" /db_xref="EnsemblGenomes-Gn:BSU10650" /db_xref="EnsemblGenomes-Tr:CAB12905" /db_xref="GOA:O06714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13088" /db_xref="UniProtKB/Swiss-Prot:O06714" /translation="MKPIALSIKGLHSFREEQTIDFEGLSGAGVFGIFGPTGSGKSSI LDAMTLALYGKVERAANNTHGILNHAEDTLSVSFTFALQTNHQISYKVERVFKRTDEM KVKTALCRFIEIKDEHTVLADKASEVNKRVEELLGLTIDDFTRAVVLPQGKFAEFLSL KGAERRHMLQRLFNLEQYGDRLVKKLRRQAQEANARKNEMLAEQSGLGEASSEAVEQA EKVLEQAEARLEAMRKNRDQAKERFTEHQEIWNVQKEKSTYEEEEKRLAEEQPHIDSM QKRLLEAETAAALKPYADRYAEAIQHEEQAEKEQTLAQKDLADRTAFFQQKHEEYEAW RQHKSEKEPELLAKQEQLSRLQEIEIKLSEAKQEEERKKADLRQKEEALQSVMNELET VTDRLTRGQNRQTELKQQLKSLQVTSDERKSCQQAAEMALRIRQTEEQIKKEKKRSEE LNLVLQKMNEEKNTLVQKTEAEENNIIQAYEAVQTVYHLVCETERSLTRMTEEARKSQ HTLHLQREKARVALLTKELAQKLTAGKPCPVCGSTDHDPSASVHETYEADSHLEEDIK RTDVLLTEAAALSQEILSAKIMLEEQSARFIEQCPFLQTIQAQNLEAAASFEHQPVYE AFETAKFEWKRIKQDILSVKTRMAQMIGAYQESLKKAEQLNEKIGFEKREADRIESII SELQSSMDSSLNMFKEAFQNQSVDEAEKWQQAIEEKDRAAEECEKRIEKSIAFLAEHE AQKEKLRESGHRLEREKLELHYAAERIKSVIADYEHELGDYAKGDSIQIKLRSVQQDL KLLKEKEQSLYEELQSAQMKLNQAKSRASASELTLQEAKGRLEKAKAAWLEHTKNTSI TRTEEVEQSLIPADELEKMKTGIDQFMDKLKQNAANLKRVAEILAGRALSESEWNETV AALQEAEDAFGAAIEEKGAAAKALAVIRDHHKRFNEIEAELKKWQMHIDRLDKLQAVF KGNTFVEFLAEEQLESVARDASARLSMLTRQRYAIEVDSEGGFVMRDDANGGVRRPVS SLSGGETFLTSLSLALALSAQIQLRGEYPLQFFFLDEGFGTLDQDLLDTVVTALEKLQ SDNLAVGVISHVQELRARLPKKLIVHPAEPSGRGTRVSLELM*" /label="sbcC CDS" gene 1063193..1066585 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /label="sbcC gene" promotor_-35 1065840..1065846 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1065861..1065872 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1065868 /Source="Nicolas_upshifts" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1065937..1066910) /Source="Nicolas_S_feature" /locus_tag="new_1147493_1148466_c" /HighExp="S6, S8, S7, BT, C30, B36, S5, C90, Pyr, B60" /AntisenseName="yisB" /AntisenseCor="0.19649597897587401" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="SigK" /TUlongPSig="0.992" /label="S379" CDS 1066599..1066901 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 22984257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 22984257; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="HNH nuclease-like essential for DNA repair" /protein_id="NP_388947.1" /db_xref="EnsemblGenomes-Gn:BSU10660" /db_xref="EnsemblGenomes-Tr:CAB12906" /db_xref="SubtiList:BG13089" /db_xref="UniProtKB/Swiss-Prot:O06715" /translation="MAKQIAGICELCGRSDVQLTEHHLTPKEEGGTFLPTAMLCIPCH KQIHALYTNQELAVRLNGMAELRSDPELARFVKWIRKQPPEKLIKTKKSNERKKKK*" /label="hlpB CDS" gene 1066599..1066901 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /label="hlpB gene" downshifts 1066881 /Source="Nicolas_upshifts" /id="D579" /incds=0 /nref=230 /ntot=269 /MaxReadThrough="1.42126" /MaxDrop="6.71114" /score="0.317490594" /energy="-14.3" /TU="NA" /idTUdmin="U861" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1066938..1067156) /gene="gerPF" /locus_tag="BSU_10670" /old_locus_tag="BSU10670" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007, 20161744" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007, 20161744; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388948.2" /db_xref="EnsemblGenomes-Gn:BSU10670" /db_xref="EnsemblGenomes-Tr:CAB12907" /db_xref="GOA:O06716" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13090" /db_xref="UniProtKB/Swiss-Prot:O06716" /translation="MPAIVGPIAINSISGGVVNFGDSFYLSPKSSSKSALGSGAGNTG DFLLLNNAVNATNYIDPDVNDQDMVGNG*" /label="gerPF CDS" gene complement(1066938..1067156) /gene="gerPF" /locus_tag="BSU_10670" /old_locus_tag="BSU10670" /label="gerPF gene" downshifts complement(1066955) /Source="Nicolas_upshifts" /id="D580" /incds=0 /nref=40 /ntot=66 /MaxReadThrough="3.93344" /MaxDrop="5.39228" /score="13.5435041" /energy="-15.3" /TU="U863" /idTUdmin="U863" /TUdmin="-989" /isTUend="FALSE" /label="downshifts" CDS complement(1067188..1067589) /gene="gerPE" /locus_tag="BSU_10680" /old_locus_tag="BSU10680" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388949.1" /db_xref="EnsemblGenomes-Gn:BSU10680" /db_xref="EnsemblGenomes-Tr:CAB12908" /db_xref="GOA:O06717" /db_xref="InterPro:IPR024496" /db_xref="SubtiList:BG13091" /db_xref="UniProtKB/Swiss-Prot:O06717" /translation="MLKRISRIRLVKFNSLGIASVFQVGDTNEIDMSVKVFAVQRSLS TFYHNEGSFNKKEYQIFQQQAVKPLPETGVQSAFCHEVPAIYVRSIKIQGVSASSVLH AGSASLIRGDARLKHIRQIQSPRSQSPAKNI*" /label="gerPE CDS" gene complement(1067188..1067589) /gene="gerPE" /locus_tag="BSU_10680" /old_locus_tag="BSU10680" /label="gerPE gene" CDS complement(1067589..1067765) /gene="gerPD" /locus_tag="BSU_10690" /old_locus_tag="BSU10690" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388950.1" /db_xref="EnsemblGenomes-Gn:BSU10690" /db_xref="EnsemblGenomes-Tr:CAB12909" /db_xref="GOA:O06718" /db_xref="InterPro:IPR017257" /db_xref="SubtiList:BG13092" /db_xref="UniProtKB/Swiss-Prot:O06718" /translation="MIFTVINRSLEVGDIRMNGVSSSSVFHIGDTESIYLSSIFDTPP ESLIIGPFAPLAPE*" /label="gerPD CDS" gene complement(1067589..1067765) /gene="gerPD" /locus_tag="BSU_10690" /old_locus_tag="BSU10690" /label="gerPD gene" CDS complement(1067762..1068379) /gene="gerPC" /locus_tag="BSU_10700" /old_locus_tag="BSU10700" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388951.1" /db_xref="EnsemblGenomes-Gn:BSU10700" /db_xref="EnsemblGenomes-Tr:CAB12910" /db_xref="GOA:O06719" /db_xref="InterPro:IPR019673" /db_xref="SubtiList:BG13093" /db_xref="UniProtKB/Swiss-Prot:O06719" /translation="MYDQSVSSYLQNLNSFVQQQAIHIQQLERQLKEIQTEMNTMKQR PATTIERVEYKFDQLKIERLDGTLNIGLNPTDPNSVQNFDVSQSTPQIGMMQQEESAQ LMQQIRQNVDMYLTEEIPDILEQLENQYDSRLDDTNRHHVIEDIRKQMDSRIHYYMSH IKKEENTPPAQYAEHIAEHVKRDVIRAVEHFLEHIPSEMKGDEQA*" /label="gerPC CDS" gene complement(1067762..1068379) /gene="gerPC" /locus_tag="BSU_10700" /old_locus_tag="BSU10700" /label="gerPC gene" CDS complement(1068402..1068635) /gene="gerPB" /locus_tag="BSU_10710" /old_locus_tag="BSU10710" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388952.2" /db_xref="EnsemblGenomes-Gn:BSU10710" /db_xref="EnsemblGenomes-Tr:CAB12911" /db_xref="GOA:O06720" /db_xref="InterPro:IPR024255" /db_xref="SubtiList:BG13094" /db_xref="UniProtKB/Swiss-Prot:O06720" /translation="MNFYINQTIQINYLRLESISNSSILQIGSAGSIKSLSNLYNTGS YVEPAPEVSGSGQPLQLQEPDTGSLVPLQPPGR*" /label="gerPB CDS" gene complement(1068402..1068635) /gene="gerPB" /locus_tag="BSU_10710" /old_locus_tag="BSU10710" /label="gerPB gene" CDS complement(1068650..1068871) /gene="gerPA" /locus_tag="BSU_10720" /old_locus_tag="BSU10720" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388953.1" /db_xref="EnsemblGenomes-Gn:BSU10720" /db_xref="EnsemblGenomes-Tr:CAB12912" /db_xref="GOA:O06721" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13095" /db_xref="UniProtKB/Swiss-Prot:O06721" /translation="MPAIVGAFKINAIGTSGVVHIGDCITISPQAQVRTFAGAGSFNT GDSLKVMNYQNATNVYDNDAVDQPIVANA*" /label="gerPA CDS" gene complement(1068650..1068871) /gene="gerPA" /locus_tag="BSU_10720" /old_locus_tag="BSU10720" /label="gerPA gene" S_feature complement(1068872..1068958) /Source="Nicolas_S_feature" /locus_tag="new_1150428_1150514_c" /HighExp="S6, S8, S7, S5, BT, B36, B60, G/S, Pyr, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="SigK" /TUlongPSig="0.992" /label="S380" promotor_-35 1068886..1068892 /Source="Nicolas_upshift_promotors" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1068906..1068925 /Source="Nicolas_upshift_promotors" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1068908..1069563 /Source="Nicolas_S_feature" /locus_tag="new_1150464_1151119" /HighExp="Salt, BC, Sw, S8, Heat, M9-stat, S7, Etha, BMM, Lbtran" /AntisenseName="yisI" /AntisenseCor="3.97396613023396E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="0.17396" /TUshortSig="SigA" /TUshortPSig="0.733" /TUlongSig="NA" /TUlongPSig="NA" /label="S381" upshifts 1068908 /Source="Nicolas_upshifts" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1068945..1068964) /Source="Nicolas_upshift_promotors" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1068958) /Source="Nicolas_upshifts" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1068960..1069089) /Source="Nicolas_S_feature" /locus_tag="new_1150516_1150645_c" /HighExp="S6, S8, S7, T5.0H, T3.30H, T4.0H, S5, T3.0H, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S382" promotor_-35 complement(1068977..1068986) /Source="Nicolas_upshift_promotors" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1069091..1069293) /Source="Nicolas_S_feature" /locus_tag="new_1150647_1150849_c" /HighExp="T5.0H, T4.0H, T3.30H, S6, M9-stat, T3.0H, S8, S7, T2.30H, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.976, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S383" downshifts complement(1069134) /Source="Nicolas_upshifts" /id="D581" /incds=0 /nref=13 /ntot=116 /MaxReadThrough="3.97434" /MaxDrop="3.59184" /score="13.5435041" /energy="-15.3" /TU="U865" /idTUdmin="U864" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1069294..1069464) /gene="pchI" /locus_tag="BSU_10730" /old_locus_tag="BSU10730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11679073, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11679073, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Spo0A-P phosphatase (iron-metabolism related)" /protein_id="NP_388954.1" /db_xref="EnsemblGenomes-Gn:BSU10730" /db_xref="EnsemblGenomes-Tr:CAB12913" /db_xref="GOA:O06722" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG13096" /db_xref="UniProtKB/Swiss-Prot:O06722" /translation="MNSKIEEMRITLIETAQKYGMNSKETIQCSQELDILLNTRIKEE MIFGRYLENSRM*" /label="pchI CDS" gene complement(1069294..1069464) /gene="pchI" /locus_tag="BSU_10730" /old_locus_tag="BSU10730" /label="pchI gene" misc_feature complement(1069508..1069527) /Source="Nicolas_upshift_promotors" /id="U864" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.386613386613387" /psig="0.976023976023976" /xcortree=2921 /SigmaFactorBS="gcttttttagtcaaattgacgaaaggcaaccttttgagccaa aaTAGGTTATACTAACGATATCctgtatttatatcaaaataaaatctagaattggaga t" /listShort="yisI, S383" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1069511) /Source="Nicolas_upshifts" /id="U864" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.386613386613387" /psig="0.976023976023976" /xcortree=2921 /SigmaFactorBS="gcttttttagtcaaattgacgaaaggcaaccttttgagccaa aaTAGGTTATACTAACGATATCctgtatttatatcaaaataaaatctagaattggaga t" /listShort="yisI, S383" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1069513..1069609) /Source="Nicolas_S_feature" /locus_tag="new_1151069_1151165_c" /HighExp="S6, S8, S7, S5, BT, Pyr, G/S, Glucon, SMMPr, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S384" downshifts 1069520 /Source="Nicolas_upshifts" /id="D582" /incds=0 /nref=3 /ntot=54 /MaxReadThrough="4.52913" /MaxDrop="3.35342" /score="12.6645711" /energy="-10.3" /TU="U862" /idTUdmin="U862" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" S_feature 1069565..1069729 /Source="Nicolas_S_feature" /locus_tag="new_1151121_1151285" /HighExp="Salt, S8, S7, BC, Heat, H2O2, Sw, Oxctl, MG-0.2, MG-0.1" /AntisenseName="yisJ" /AntisenseCor="0.24461808844813801" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.733" /TUlongSig="NA" /TUlongPSig="NA" /label="S385" CDS complement(1069610..1070533) /gene="yisJ" /locus_tag="BSU_10740" /old_locus_tag="BSU10740" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein, CotH paralog" /protein_id="NP_388955.1" /db_xref="EnsemblGenomes-Gn:BSU10740" /db_xref="EnsemblGenomes-Tr:CAB12914" /db_xref="GOA:O06723" /db_xref="InterPro:IPR014867" /db_xref="SubtiList:BG13097" /db_xref="UniProtKB/Swiss-Prot:O06723" /translation="MERVHLFFHREQLKRKGTAKGLFVTDRSVSPILLTQRDRAEKAS YEISWEKSLLGERTLFLNAEQDDPSLMRRRLAYCFFDQIGVPAPVASYSFLTINGQPE GIYLNIKNHQPAGKRSYGVKTADPRVPLSLFNNDSSAFLHEFFILIRTAGDDELAERI KLYLDVKLFFLWLIGNTCTNQGFYYTFCLNESGRLYVSPMETRSLAVQEWYEEDPLLT KGKTLSSRLLSIPAFRSQYHTLMKNVLKRSFTIERLSPLINEWHLDICQSAADDPFIK KSPFQIEKEQTNILREIEERQDFLQAHLARL*" /label="yisJ CDS" gene complement(1069610..1070533) /gene="yisJ" /locus_tag="BSU_10740" /old_locus_tag="BSU10740" /label="yisJ gene" promotor_-10 complement(1070555..1070574) /Source="Nicolas_upshift_promotors" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /label="promotor_-10" upshifts complement(1070566) /Source="Nicolas_upshifts" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /label="upshifts" promotor_-35 complement(1070588..1070597) /Source="Nicolas_upshift_promotors" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /label="promotor_-35" promotor_-35 1070617..1070625 /Source="Nicolas_upshift_promotors" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" /label="promotor_-35" promotor_-10 1070637..1070655 /Source="Nicolas_upshift_promotors" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" /label="promotor_-10" upshifts 1070642 /Source="Nicolas_upshifts" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" /label="upshifts" CDS 1070688..1071593 /gene="mblK" /locus_tag="BSU_10750" /old_locus_tag="BSU10750" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16847875, 27215790, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16847875, 27215790, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydrolase/isomerase involved in remodelling the bacterial envelope" /protein_id="NP_388956.1" /db_xref="EnsemblGenomes-Gn:BSU10750" /db_xref="EnsemblGenomes-Tr:CAB12915" /db_xref="GOA:O06724" /db_xref="InterPro:IPR011234" /db_xref="InterPro:IPR036663" /db_xref="SubtiList:BG13098" /db_xref="UniProtKB/Swiss-Prot:O06724" /translation="MKFATGELYNRMFVGLIIDDEKIMDLQKAEKKLFELETIPGSLI ECIAEGDKFVAHARQLAEWAKKPNDELGSFMYSLSEVKLHAPIPKPSKNIICIGKNYR DHAIEMGSEADIPEHPMVFTKSPVTVTGHGDIVKSHEEVTSQLDYEGELAVVIGKSGT RISKEDAYDHVFGYTIVNDITARDLQKRHKQFFIGKSLDTTCPMGPVLVHKSSIQEPE RLKVETRVNGELRQSGSASDMIFSIPELIETLSKGMTLEAGDIIATGTPSGVGKGFTP PKFLRSGDKIDITIDPIGTLSNQIG*" /label="mblK CDS" gene 1070688..1071593 /gene="mblK" /locus_tag="BSU_10750" /old_locus_tag="BSU10750" /label="mblK gene" S_feature 1071594..1071674 /Source="Nicolas_S_feature" /locus_tag="new_1153150_1153230" /HighExp="S2, Lbstat, S1, Etha, SMMPr, M0t90, M40t90, LoTm, T-4.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S386" promotor_-35 1071644..1071647 /Source="Nicolas_upshift_promotors" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1071664..1071683 /Source="Nicolas_upshift_promotors" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1071676 /Source="Nicolas_upshifts" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" /label="upshifts" CDS 1071709..1072065 /gene="yisL" /locus_tag="BSU_10760" /old_locus_tag="BSU10760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27215790; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388957.1" /db_xref="EnsemblGenomes-Gn:BSU10760" /db_xref="EnsemblGenomes-Tr:CAB12916" /db_xref="GOA:O06725" /db_xref="InterPro:IPR010899" /db_xref="SubtiList:BG13099" /db_xref="UniProtKB/Swiss-Prot:O06725" /translation="MTHLHITTWVVALILLFVSYSLYSSGSAKGAKITHMILRLFYIL IILTGAELFVRFANWNGEYAGKMILGIITIGLMEMLLIRKKKEKSTGGLWVGFVIVLL LTVLLGLHLPIGFQLF*" /label="yisL CDS" gene 1071709..1072065 /gene="yisL" /locus_tag="BSU_10760" /old_locus_tag="BSU10760" /label="yisL gene" downshifts 1071962 /Source="Nicolas_upshifts" /id="D583" /incds=1 /nref=1 /ntot=44 /MaxReadThrough="4.28837" /MaxDrop="2.46999" /score="41.4247437" /energy="-11.7" /TU="U866,U867" /idTUdmin="U867" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 1072053 /Source="Nicolas_upshifts" /id="D584" /incds=0 /nref=17 /ntot=162 /MaxReadThrough="3.06092" /MaxDrop="3.41506" /score="41.4247437" /energy="-11.7" /TU="U866" /idTUdmin="U867" /TUdmin=3 /isTUend="TRUE" /label="downshifts" upshifts 1072186 /Source="Nicolas_upshifts" /id="U868" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.486513486513487" /psig="0.732267732267732" /xcortree=2782 /SigmaFactorBS="atattccaaatcatttaaaataaccttaaaattccctgtaag cggtatctcgtcctatgaaatTATGATACCTTCAAGGAGATtcattattttgcaggag g" /listShort="wprA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1072189..1072208 /Source="Nicolas_upshift_promotors" /id="U868" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.486513486513487" /psig="0.732267732267732" /xcortree=2782 /SigmaFactorBS="atattccaaatcatttaaaataaccttaaaattccctgtaag cggtatctcgtcctatgaaatTATGATACCTTCAAGGAGATtcattattttgcaggag g" /listShort="wprA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1072233..1074917 /gene="wprA" /locus_tag="BSU_10770" /old_locus_tag="BSU10770" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9004506, 9675284, 10336490, 15205417, 17269748, 21636651, 23180473, 25313396" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9004506, 9675284, 10336490, 15205417, 17269748, 21636651, 23180473, 25313396; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall-associated protease" /protein_id="NP_388958.1" /db_xref="EnsemblGenomes-Gn:BSU10770" /db_xref="EnsemblGenomes-Tr:CAB12917" /db_xref="GOA:P54423" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034084" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG11846" /db_xref="UniProtKB/Swiss-Prot:P54423" /translation="MKRRKFSSVVAAVLIFALIFSLFSPGTKAAAAGAIDQAAALENG KEQTGAMKEPEQVKWYKVTPGATDIQKNSHMALTVKSDSVLNVSVYPSKEKALKDETF EMYRSFTAEDGKSEVIFPYAWSGPYYVKVEYLGEEEPEDGGTAEAAAEAKYTIGYKGT KKQPSDLEEEEACPVEMSVDQKKSGKGILDKLRSIRDEQLSQTAEGKELTSLYYKAAP FIVAKLALNKTARNEIYQDLVTLKPLFDDVSENGASSSYKVTEKDQKAINRLYDKALQ SVPSFLKEEIKKQADRLNMKQLQGKTAGAILTENNIAAKSEVQTTKVIFKVKDNKSLS SVHNEMKGFSASAQSKKDISNVKKAKKLFDNLYSFELPKDEKQNGAYTASAKRVKSAA ATLSKMSNVEFAEPVQEYKSLANDIQYPYQWPLKNNGENGGVKNADVKYEPANTLLSK RKLNDTLIAVVDTGVDSTLADLKGKVRTDLGHNFVGRNNNAMDDQGHGTHVAGIIAAQ SDNGYSMTGLNAKAKIIPVKVLDSAGSGDTEQIALGIKYAADKGAKVINLSLGGGYSR VLEFALKYAADKNVLIAAASGNDGENALSYPASSKYVMSVGATNRMDMTADFSNYGKG LDISAPGSDIPSLVPNGNVTYMSGTSMATPYAAAAAGLLFAQNPKLKRTEVEDMLKKT ADDISFESVDGGEEELYDDYGDPIEIPKTPGVDWHSGYGRLNVMKAVSAADLQLKVNK LESTQTAVRGSAKEGTLIEVMNGKKKLGSAKAGKDNAFKVNIATQKQDQVLYLKATKG DAKTSYKVVVVKGKPSGTPKVNAVKTKDTAVKGKANSKAMIRVKNKSKKVIASAKADA KGTFSVKIKKQKAGTVLYVTAVDTDKKESKEAKVVVEK*" /label="wprA CDS" gene 1072233..1074917 /gene="wprA" /locus_tag="BSU_10770" /old_locus_tag="BSU10770" /label="wprA gene" downshifts complement(1072401) /Source="Nicolas_upshifts" /id="D585" /incds=1 /nref=2 /ntot=155 /MaxReadThrough="0.14981" /MaxDrop="3.98572" /score="9.01750245" /energy="-8" /TU="NA" /idTUdmin="U869" /TUdmin=2563 /isTUend="FALSE" /label="downshifts" downshifts 1074909 /Source="Nicolas_upshifts" /id="D586" /incds=0 /nref=239 /ntot=267 /MaxReadThrough="1.55031" /MaxDrop="8.31576" /score="36.3638154" /energy="-12.3" /TU="NA" /idTUdmin="U868" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1074948..1075535) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388959.1" /db_xref="EnsemblGenomes-Gn:BSU10780" /db_xref="EnsemblGenomes-Tr:CAB12918" /db_xref="InterPro:IPR024488" /db_xref="SubtiList:BG12239" /db_xref="UniProtKB/Swiss-Prot:O06727" /translation="MKKKETAWMKRKQLLYTEERKWEYGTILIEDGICLIENGEGDIL LADSLQHSPIWIHHKGKWEQAGFQDKLVLACGAENISLSGGERIRYEKSVKRPLMALL DSLDDETFLAFLQHLHSFGLSVFDCVFSYNKGVFSNTSAGQGVSFYHFSNDTAQCAMQ HHYNYSSEGTGDRFEWTASNGKRSIMYTAVQRGRK*" /label="yisN CDS" gene complement(1074948..1075535) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /label="yisN gene" promotor_-10 complement(1075550..1075569) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1075569) /Source="Nicolas_upshifts" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1075585..1075587) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1075590..1075596 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1075608 /Source="Nicolas_upshifts" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1075611..1075629 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1075614..1075680 /Source="Nicolas_S_feature" /locus_tag="new_1157170_1157236" /HighExp="S6, S5, S7, S8, B36, S4, BT, G/S, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S387" CDS 1075681..1077525 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /EC_number="6.3.5.4" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (sporulation related)" /protein_id="NP_388960.2" /db_xref="EnsemblGenomes-Gn:BSU10790" /db_xref="EnsemblGenomes-Tr:CAB12919" /db_xref="GOA:O05272" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG12240" /db_xref="UniProtKB/Swiss-Prot:O05272" /translation="MCGITGWVDFKKQLVQEKQTMDRMTDTLSKRGPDDSNVWGEHHV LFGHKRLAVVDIEGGRQPMACTYKGDTYTIIYNGELYNTEDLRKELRARGHQFERTSD TEVLLHSYIEWQEDCVDHLNGIFAFAVWDEKRNLLFAARDRLGVKPFFYTKEGSSFLF GSEIKAILAHPDIKARVDRTGLSEIFGLGPSRTPGTGIFKGIKEIRPAHALTFSKDGL NIWRYWNVESEKHTDSFDDTVANVRSLFQDAVTRQLVSDVPVCTFLSGGLDSSAITAI AAGHFEKEGKAPLHTYSIDYEENDKYFQASAFQPNDDGPWIEKMTEAFGTTHHKCVIS QKDLVDHLEEAVLVKDLPGMADVDSSLLWFCREIKKDFVVSLSGECADEIFGGYPWFH TADVESGFPWMRSTEERIKLLSDSWQKKLNLKEYVNAKYEETLAETPLLDGETGVDKA RRQLFYLNMLWFMTNLLDRKDRMSMGASLEVRVPFADHRLVEYVWNIPWEMKMHDNRE KGILRKALEGILPDDILYRKKSPYPKTHHPEYTKGVSEWLKTIRSQKDSVLHTLLDRK QLDQLLETEGSSFKVPWFGQLMKGPQLIAHLAQIHTWFEAYRIDIDER*" /label="asnO CDS" gene 1075681..1077525 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /label="asnO gene" S_feature 1077526..1077593 /Source="Nicolas_S_feature" /locus_tag="new_1159082_1159149" /HighExp="S6, S5, S7, B36, BT, S8, S4, B60, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S388" downshifts 1077550 /Source="Nicolas_upshifts" /id="D587" /incds=0 /nref=12 /ntot=43 /MaxReadThrough="3.29969" /MaxDrop="4.67478" /score="3.55879494" /energy="-14.8" /TU="U870" /idTUdmin="U870" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" CDS complement(1077655..1078134) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation related)" /protein_id="YP_054576.1" /db_xref="EnsemblGenomes-Gn:BSU10800" /db_xref="EnsemblGenomes-Tr:CAE01451" /db_xref="GOA:Q7WY73" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="PDB:2QE9" /db_xref="SubtiList:BG14187" /db_xref="UniProtKB/Swiss-Prot:Q7WY73" /translation="MMKFFEYNWQVRDQWFTWCHQLTTEELLKNRLGGVENILYTLFH IIDVEYSWIRAIQGKEDIAVQFADYQTLNKVKSLSNTFRTEIIDVLQTHSDQIKDELV SVPWETGVLYTRDEILHHIIAHEIHHIGQLSVWARELKLSPVSASFIGRTLKPIHSY* " /label="yizA CDS" gene complement(1077655..1078134) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /label="yizA gene" upshifts complement(1078154) /Source="Nicolas_upshifts" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1078158..1078176) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1078187..1078195) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1078326..1078330 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1078343 /Source="Nicolas_upshifts" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1078345..1078364 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1078366..1079190 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /EC_number="3.6.1.27" /experiment="publication(s) with functional evidences, PMID:23295493, 25308276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23295493, 25308276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate phosphatase" /protein_id="NP_388961.1" /db_xref="EnsemblGenomes-Gn:BSU10810" /db_xref="EnsemblGenomes-Tr:CAB12920" /db_xref="GOA:O06728" /db_xref="InterPro:IPR002060" /db_xref="InterPro:IPR008949" /db_xref="PDB:3WE9" /db_xref="SubtiList:BG12241" /db_xref="UniProtKB/Swiss-Prot:O06728" /translation="MIHRSEKMKEIKEAYQQCGQIVGEYAPACFKALSYLPLKQRQAS WAVLSFCHTAASADEKVLPAFEAKADHVYQRTNNGKQHLWKAFDHAYRTFTLESEPFR EFIAAQKEDAKPYDDLDELLMYAYRTGGAAGLMLLPILTRRKQDQLKQAAVSLGLAIQ LVRFLSDLGTDQQKNRIPRQVMQQFGYTEADLQKGTVNKAFTMTWEYIAFEAEAYLEE CQDALPLFPQYSQKTVKAALHLHRAVLEKIRAKQHDVFQYHFALTETEVKQILSDI*" /label="farP CDS" gene 1078366..1079190 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /label="farP gene" promotor_-35 1078578..1078584 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1078599..1078617 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1078606 /Source="Nicolas_upshifts" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1079200..1080650 /Source="Nicolas_S_feature" /locus_tag="new_1160756_1162206" /HighExp="Salt, Etha, Sw, Cold, G150, G180, G135, LBGtran, Heat, Paraq" /AntisenseName="yisQ" /AntisenseCor="0.19511630802652" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S389" CDS complement(1079220..1080587) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na(+)-driven efflux transporter" /protein_id="NP_388962.1" /db_xref="EnsemblGenomes-Gn:BSU10820" /db_xref="EnsemblGenomes-Tr:CAB12921" /db_xref="GOA:O07940" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG12242" /db_xref="UniProtKB/Swiss-Prot:O07940" /translation="MKQAVFKSTALKKPADKTFSLFSLTWPIFIEVSLYMFMGNADTL MLSQYSDNSVAAVGVSNQILNLIIVMFSFIATGTTVIISQFLGSRQKKEAMEVAYVSI GANFFISLAISAVVFFAAVPLLHMMGLSDALMPDAKVFLQVVGGLSFIQALIMTFSAI LKSYGYTKDTMFVTIGMNILNIAGNFVVIFGLFGFPVLGVAGVAMSTSIARVIGLIAM IVIVNKRIQLKMSLKKVFHMHKEHLRKLLKIGIPSAGEQLSYNLSQMIVTYFIAIMGA QALTTKVYTQNITMFILLFGTAISQGTQILIGRYIGGKQFDAAYERCMKSLYWALGIA AATSVLMTIFSKDLIGLFTQSPDIIATASLLIAMTIILEPGRSFNVIIINSLRAAGDA KFPVYMAMISMWGIGLPLAYLFGIHLGFGLAGIWISFIADEWVRGILMYRRWRSRIWI QKGMA*" /label="yisQ CDS" gene complement(1079220..1080587) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /label="yisQ gene" promotor_-35 1080619..1080626 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1080640..1080659 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1080652 /Source="Nicolas_upshifts" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="upshifts" CDS 1080711..1081574 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388963.1" /db_xref="EnsemblGenomes-Gn:BSU10830" /db_xref="EnsemblGenomes-Tr:CAB12922" /db_xref="GOA:P40331" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11064" /db_xref="UniProtKB/Swiss-Prot:P40331" /translation="MPRILFTVPPFPVFIAAGEGVFKKGETHVKRVFSVFDLIYVKQG TLYITENETSFSVEGGEYILLSPGLEHYGTKGSDEATSYYWLHFDEHRYEFTAKGGSN WSELQQEKGSFEELARYGLALPRKGKVQRPQFMAQQFEKLIDYSAENSDLPLRKQILF EELMLHLQKEAFQIPSAKERVAWEAARYLQEHYKEKTTIKDLSLALHYHQDYVSRCMQ QVLGVTPAQYTNRVRMTEAKRLLSSTNDKMGVIAETVGMEDPTYFSKLFKQIEGISPI EYRKIVSRKVQ*" /label="yisR CDS" gene 1080711..1081574 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /label="yisR gene" CDS 1081592..1082605 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8407808, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8407808, 23504016, 28693424; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of iolX (LacI family)" /protein_id="NP_388964.1" /db_xref="EnsemblGenomes-Gn:BSU10840" /db_xref="EnsemblGenomes-Tr:CAB12923" /db_xref="GOA:P37947" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10847" /db_xref="UniProtKB/Swiss-Prot:P37947" /translation="MKTTIYDVAKAAGVSITTVSRVINNTGRISDKTRQKVMNVMNEM AYTPNVHAAALTGKRTNMIALVAPDISNPFYGELAKSIEERADELGFQMLICSTDYDP KKETKYFSVLKQKKVDGIIFATGIESHDSMSALEEIASEQIPIAMISQDKPLLPMDIV VIDDVRGGYEAAKHLLSLGHTNIACIIGDGSTTGEKNRIKGFRQAMEEAGVPIDESLI IQTRFSLESGKEEAGKLLDRNAPTAIFAFNDVLACAAIQAARIRGIKVPDDLSIIGFD NTILAEMAAPPLTTVAQPIKEMGRSVIELLAEAIEGKRKAKQKIVLPPELVVRHSTSP LNT*" /label="iolQ CDS" gene 1081592..1082605 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /label="iolQ gene" downshifts 1082588 /Source="Nicolas_upshifts" /id="D588" /incds=0 /nref=13 /ntot=204 /MaxReadThrough="0.51227" /MaxDrop="3.29173" /score="25.1260914" /energy="-9.6" /TU="NA" /idTUdmin="U874" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_-35 1082657..1082664 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1082679..1082698 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1082698..1082813 /Source="Nicolas_S_feature" /locus_tag="new_1164254_1164369" /HighExp="Lbstat, M40t90, M0t90, BI, G150, dia0, Mt0, Lbexp, Lbtran, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S390" upshifts 1082698 /Source="Nicolas_upshifts" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="upshifts" CDS 1082814..1083842 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /EC_number="1.1.1.370" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11160890, 20133360, 23109554, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 20133360, 23109554, 23504016, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NAD(+))" /protein_id="NP_388965.1" /db_xref="EnsemblGenomes-Gn:BSU10850" /db_xref="EnsemblGenomes-Tr:CAB12924" /db_xref="GOA:P40332" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11065" /db_xref="UniProtKB/Swiss-Prot:P40332" /translation="MEHQVRCAVLGLGRLGYYHAKNLVTSVPGAKLVCVGDPLKGRAE QVARELGIEKWSEDPYEVLEDPGIDAVIIVTPTSTHGDMIIKAAENGKQIFVEKPLTL SLEESKAASEKVKETGVICQVGFMRRFDPAYADAKRRIDAGEIGKPIYYKGFTRDQGA PPAEFIKHSGGIFIDCSIHDYDIARYLLGAEITSVSGHGRILNNPFMEQYGDVDQALT YIEFDSGAAGDVEASRTSPYGHDIRAEVIGTEGSIFIGTLRHQHVTILSAKGSSFDII PDFQTRFHEAYCLELQHFAECVRNGKTPIVTDIDATINLEVGIAATNSFRNGMPVQLD VKRAYTGM*" /label="iolX CDS" gene 1082814..1083842 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /label="iolX gene" downshifts 1083864 /Source="Nicolas_upshifts" /id="D589" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="0.33001" /MaxDrop="3.45406" /score="8.69111487" /energy="-13.4" /TU="NA" /idTUdmin="U875" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1083893..1084402) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25651892; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative enzyme regulator of activity" /protein_id="NP_388966.2" /db_xref="EnsemblGenomes-Gn:BSU10860" /db_xref="EnsemblGenomes-Tr:CAB12925" /db_xref="GOA:O07939" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG12243" /db_xref="UniProtKB/Swiss-Prot:O07939" /translation="MTDAKQFYDYHSWANKKIFTHIENLPEETAYQEVKSVFPSVSDV LLHMCRADYIWLNVLSGVAYQEIIDSAGKLQSAQGNMAAIKQHAAELESQYHDFFSRQ TDLEQTFTMQHPKLGTLESTYADTILHVVNHGTYHRGNVTAMLRQLDHSGVPTDYMYY LYEKRESKG*" /label="yisT CDS" gene complement(1083893..1084402) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /label="yisT gene" downshifts complement(1083912) /Source="Nicolas_upshifts" /id="D590" /incds=0 /nref=81 /ntot=251 /MaxReadThrough="-0.0416600000000003" /MaxDrop="7.15629" /score="27.2292301" /energy="-13.4" /TU="NA" /idTUdmin="U876" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1084415..1084433) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1084431) /Source="Nicolas_upshifts" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1084445..1084453) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1084452..1085114) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid related metabolite efflux transporter" /protein_id="NP_388967.1" /db_xref="EnsemblGenomes-Gn:BSU10870" /db_xref="EnsemblGenomes-Tr:CAB12926" /db_xref="GOA:O06730" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG13100" /db_xref="UniProtKB/Swiss-Prot:O06730" /translation="MTISLMIEKKCERSFFSMNAIIHGIVLAFGLILPLGVQNVFIFQ QGALQKHIWRALPAVISASVCDTLLIVLAVAGVSVIVQELPVFETVMMAGGFLFLLYM GWVTWNIRPNTSQNEKHTFTPKKQAAFAAAVSLLNPHAILDTIGVIGTSSLQYSGLEK WLFMAACIAVSWIWFISLAIAGRLFQTIDTSGRLMLIVNKCSAAVMWAAAGYFGVSLF CN*" /label="yisU CDS" gene complement(1084452..1085114) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /label="yisU gene" promotor_-35 1085133..1085139 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1085153..1085172 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1085162 /Source="Nicolas_upshifts" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="upshifts" CDS 1085181..1086635 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 19383706; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388968.2" /db_xref="EnsemblGenomes-Gn:BSU10880" /db_xref="EnsemblGenomes-Tr:CAB12927" /db_xref="GOA:Q796Q6" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13101" /db_xref="UniProtKB/Swiss-Prot:Q796Q6" /translation="MTLSQWQPSRKSDVPLHRQIEQYMKDKILHGEWAVGTKIPSQRT LADMFQVNRSTVTAAIDELTSQGLLEGRKGGGTKVVNSTWSVLTAEPPLDWSDYVRSG IHRANSSIIQAINQNEPRADIIRLGTGELSPDLVPADTIGRMFQQINPGVLSLGYEQP KGNRQLREAVADHLKGKKIHVSPSAILIVSGALQALQLISIGLLKRDSVILTEKPSYL QSLHVFQSAGMRLRGLPMDDEGVKAGLVSSNRKQYGGQLLYTIPSFHNPTGTVMSEQR RKEIISLSKKEQMPIIEDDAYGDLWFEEKPPQPLKAMDHEGNILYLGAFSKTVSPGLR IGWLAGPEPVIERLADIKMQTDYGSSGLSQWAAAEWLSQGYYEEHLTWVRRKLKERRD AAVHFLERYAGDIATWRIPAGGFYIWVTFHKNLPVSRFFYELLKRQVLVNPGYIYDGE DRNSIRLSYSYASLGDLETGIKAAAETARRLMMS*" /label="yisV CDS" gene 1085181..1086635 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /label="yisV gene" S_feature complement(1086490..1086642) /Source="Nicolas_S_feature" /locus_tag="new_1168046_1168198_c" /HighExp="Diami, Sw, C90, LBGstat, dia15, Paraq, dia5, BC, M40t45, Oxctl" /AntisenseName="yisV" /AntisenseCor="0.69858995161852" /AntisenseRegPval="-40" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S391" downshifts complement(1086525) /Source="Nicolas_upshifts" /id="D591" /incds=1 /nref=2 /ntot=84 /MaxReadThrough="2.36735" /MaxDrop="2.81041" /score="-5.131548" /energy="-17.3" /TU="NA" /idTUdmin="U879" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1086643..1087281) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388970.1" /db_xref="EnsemblGenomes-Gn:BSU10890" /db_xref="EnsemblGenomes-Tr:CAB12929" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG13103" /db_xref="UniProtKB/Swiss-Prot:O06733" /translation="MNKIAIQKPNIPENLQTADFHDAVTQDDVISMHLFEDCTICGED IERLCVEKTVFRNVVFIDVSFRHIELTDVIFEKCDLSNADFSGAVIHRTSVKQSKMVG MNVAEATLRNVSFEECHGHFSSFSYSNMKQVRFDHCALMQSECSDTVLQQTHFDGCEL EGASFTGTSLQNMDISTCRFEQLHVSLDKLKGCKIAPEHAIAFARALGAVIV*" /label="yisX CDS" gene complement(1086643..1087281) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /label="yisX gene" S_feature complement(1087282..1087416) /Source="Nicolas_S_feature" /locus_tag="new_1168838_1168972_c" /HighExp="Diami, dia15, dia5, C90, BC, Paraq, LBGstat, Lbtran, HiOs, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S392" promotor_-35 1087330..1087335 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1087351..1087369 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1087352 /Source="Nicolas_upshifts" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="upshifts" S_feature 1087362..1087486 /Source="Nicolas_S_feature" /locus_tag="new_1168918_1169042" /HighExp="S6, S5, S8, S7, S4, BT, B36, S3, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S393" promotor_-10 complement(1087402..1087421) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1087416) /Source="Nicolas_upshifts" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1087436..1087443) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1087487..1088293 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl hydrolase or peroxidase" /protein_id="NP_388971.1" /db_xref="EnsemblGenomes-Gn:BSU10900" /db_xref="EnsemblGenomes-Tr:CAB12930" /db_xref="GOA:O06734" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13104" /db_xref="UniProtKB/Swiss-Prot:O06734" /translation="MGHYIKTEEHVTLFVEDIGHGRPIIFLHGWPLNHKMFEYQMNEL PKRGFRFIGVDLRGYGQSDRPWEGYDYDTMADDVKAVIYTLQLENAILAGFSMGGAIA IRYMARHEGADVDKLILLSAAAPAFTKRPGYPYGMRKQDIDDMIELFKADRPKTLADL GKQFFEKKVSPELRQWFLNLMLEASSYGTIHSGIALRDEDLRKELAAIKVPTLILHGR KDRIAPFDFAKELKRGIKQSELVPFANSGHGAFYEEKEKINSLIAQFSNS*" /label="yisY CDS" gene 1087487..1088293 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /label="yisY gene" downshifts 1088286 /Source="Nicolas_upshifts" /id="D592" /incds=0 /nref=4 /ntot=24 /MaxReadThrough="2.64682" /MaxDrop="5.60718" /score="8.70914085" /energy="-6.5" /TU="NA" /idTUdmin="U878" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1088321..1088920) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /EC_number="2.7.1.25" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenylylsulfate kinase" /protein_id="NP_388972.1" /db_xref="EnsemblGenomes-Gn:BSU10910" /db_xref="EnsemblGenomes-Tr:CAB12931" /db_xref="GOA:O06735" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13105" /db_xref="UniProtKB/Swiss-Prot:O06735" /translation="MTHNPNIIWHPAAISKSDRQSLNGHKSCVLWFTGLSGSGKSVLA NAVDEKLYRKGIQSYVLDGDNIRHGLNKDLGFQTGDRIENIRRIGEVAKLFVDSGQMI LTAFISPFREDRDMVRALFPKGEFFEIYVKCPLHVCEQRDPKGLYKKARNGEIKHFTG IDSPYEAPLSPDFIIESDQTSISDGADLIINALQNRGII*" /label="yisZ CDS" gene complement(1088321..1088920) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /label="yisZ gene" downshifts complement(1088340) /Source="Nicolas_upshifts" /id="D593" /incds=0 /nref=35 /ntot=44 /MaxReadThrough="1.69999" /MaxDrop="6.8011" /score="17.1506785" /energy="-7.3" /TU="NA" /idTUdmin="U880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1088917..1090086) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /EC_number="2.7.7.4" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfate adenylyltransferase" /protein_id="NP_388973.2" /db_xref="EnsemblGenomes-Gn:BSU10920" /db_xref="EnsemblGenomes-Tr:CAB12932" /db_xref="GOA:O06736" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13106" /db_xref="UniProtKB/Swiss-Prot:O06736" /translation="MNGNEPHGGVLINRCDPACHFEGCACQAELDQLALSDLELIAIG GYSPLTGFLGEKDYHSVVKEMRLANGLPWSLPITLPVGEKTARQLSAGDHVKLVKDGV TYGMITVTDIYQPDKTQEALSVFKTNDPAHPGVKKLLARPDYYIGGPITVSSLPDKSF EQFYATPAETRAAFQKLGWKTIVGFQTRNPVHRAHEYIQKTALETVDGLLLHPLVGET KSDDIPSDIRMESYQALLNHYYPKDRVMLSVFPAAMRYAGPREAIFHALVRKNYGCTH FIVGRDHAGVGSYYGTYDAQNIFQSFTEEELGIKPLFFEHSFYCRKCGNMGTSKTCPH SPRDHIHLSGTKVRELLRQGKKPPKEFSRPEVAAVLIKGLHQQPVAIKQNSGELQ*" /label="yitA CDS" gene complement(1088917..1090086) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /label="yitA gene" S_feature complement(1090087..1090198) /Source="Nicolas_S_feature" /locus_tag="new_1171643_1171754_c" /HighExp="S6, S7, S8, BT, S5, B36, G/S, Pyr, SMMPr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S394" CDS complement(1090199..1090909) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospho-adenylylsulfate reductase" /protein_id="NP_388974.2" /db_xref="EnsemblGenomes-Gn:BSU10930" /db_xref="EnsemblGenomes-Tr:CAB12933" /db_xref="GOA:O06737" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13107" /db_xref="UniProtKB/Swiss-Prot:O06737" /translation="MNETITYDTWNDMLSKQITDQLIDELDVLKWAYRTYGEKIVYAC SFGAEGMVLLDLISKINKNAHIIFLDTGLHFQETYELIETVKERYPGFAIQMLEPELS LTEQGTKYGGELWKHNPNLCCQLRKIEPLKKHLSGMTAWISGLRRDQSPTRKHIQYVN LDQKFELIKICPLIHWTWDDVWTYIRLHNLPYNKLHDQHYPSIGCEMCTLPSPDPNDE RAGRWAGREKTECGLHQE*" /label="yitB CDS" gene complement(1090199..1090909) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /label="yitB gene" promotor_-10 complement(1090953..1090972) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1090975) /Source="Nicolas_upshifts" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1090985..1090994) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1091024..1091033 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1091047..1091066 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1091058 /Source="Nicolas_upshifts" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="upshifts" CDS 1091094..1091780 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /EC_number="3.1.3.71" /function="15.7: Sporulation and germination" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3346220, 11830598, 15383836, 16341843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho,3-sulfolactate phosphatase (sporulation related)" /protein_id="NP_388975.1" /db_xref="EnsemblGenomes-Gn:BSU10940" /db_xref="EnsemblGenomes-Tr:CAB12934" /db_xref="GOA:O06738" /db_xref="InterPro:IPR005238" /db_xref="InterPro:IPR036702" /db_xref="SubtiList:BG13108" /db_xref="UniProtKB/Swiss-Prot:O06738" /translation="MPIAIYQGHHHSLAPADINIVIDVIRAFTVAHYAFIGGAKEILL VRTADEAFALKDTYPDYVLTGEEKGVGISGFDLDNSPKRMAGQNMTDKSLIQKTTNGV TAALGALNAKHLFVTGFSNAKTTAQHVKKLVANDCVINIVASHPSGDDDMACAEYIKG IIEGTNVVTAAEAIERIKGSSVAEKFFDCRQPLFDSEDIVYCTKELTGDFVMKVKQDG EVPTIERVII*" /label="slpH CDS" gene 1091094..1091780 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /label="slpH gene" CDS 1091777..1092535 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /EC_number="4.4.1.19" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11830598, 15014443, 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho-3-sulfolactate synthase" /protein_id="NP_388976.1" /db_xref="EnsemblGenomes-Gn:BSU10950" /db_xref="EnsemblGenomes-Tr:CAB12935" /db_xref="GOA:O06739" /db_xref="InterPro:IPR003830" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036112" /db_xref="PDB:1U83" /db_xref="SubtiList:BG13109" /db_xref="UniProtKB/Swiss-Prot:O06739" /translation="MNDFSLELPVRTNKPRETGQSILIDNGYPLQFFKDAIAGASDYI DFVKFGWGTSLLTKDLEEKISTLKEHDITFFFGGTLFEKYVSQKKVNEFHRYCTYFGC EYIEISNGTLPMTNKEKAAYIADFSDEFLVLSEVGSKDAELASRQSSEEWLEYIVEDM EAGAEKVITEARESGTGGICSSSGDVRFQIVDDIISSDIDINRLIFEAPNKTLQQGFI QKIGPNVNLANIPFHDAIALETLRLGLRSDTFFL*" /label="slpS CDS" gene 1091777..1092535 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /label="slpS gene" downshifts 1092532 /Source="Nicolas_upshifts" /id="D594" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="2.37654" /MaxDrop="4.17689" /score="-1.32868938" /energy="-17.6" /TU="NA" /idTUdmin="U881" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1092580..1093209) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26335199; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388977.1" /db_xref="EnsemblGenomes-Gn:BSU10960" /db_xref="EnsemblGenomes-Tr:CAB12936" /db_xref="GOA:O06740" /db_xref="InterPro:IPR003740" /db_xref="SubtiList:BG13110" /db_xref="UniProtKB/Swiss-Prot:O06740" /translation="MAELLMKAKLTFMIVVGGVLQGLGMSLFLFPHDIPTGGAAGIAV LLHYLFQIPHGFSVWAVNVSMLFTALKWLEMRTFTGTLASITVTSVSVLIFDAVFPDI TSNLWLDLASGAVLLGLGIGLLYKYKISNGGFGALALMISIYRGGNPGTILLIMNCII FMVTASIIDWGIVIQALICQVISTRVIDFIYNIRLTSLPYLTPMYRHKK*" /label="yitE CDS" gene complement(1092580..1093209) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /label="yitE gene" promotor_-10 complement(1093243..1093261) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1093260) /Source="Nicolas_upshifts" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1093276..1093281) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1093305..1094420) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 11747447, 27994575; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enolase superfamily enzyme (isomerase /dehydratase)" /protein_id="NP_388978.1" /db_xref="EnsemblGenomes-Gn:BSU10970" /db_xref="EnsemblGenomes-Tr:CAB12937" /db_xref="GOA:O06741" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR036849" /db_xref="PDB:2GDQ" /db_xref="PDB:2GGE" /db_xref="SubtiList:BG13111" /db_xref="UniProtKB/Swiss-Prot:O06741" /translation="MKIVRIETFPLFHRLEKPYGDANGFKRYRTCYLIRIITESGIDG WGECVDWLPALHVGFTKRIIPFLLGKQAGSRLSLVRTIQKWHQRAASAVSMALTEIAA KAADCSVCELWGGRYREEIPVYASFQSYSDSPQWISRSVSNVEAQLKKGFEQIKVKIG GTSFKEDVRHINALQHTAGSSITMILDANQSYDAAAAFKWERYFSEWTNIGWLEEPLP FDQPQDYAMLRSRLSVPVAGGENMKGPAQYVPLLSQRCLDIIQPDVMHVNGIDEFRDC LQLARYFGVRASAHAYDGSLSRLYALFAQACLPPWSKMKNDHIEPIEWDVMENPFTDL VSLQPSKGMVHIPKGKGIGTEINMEIVNRYKWDGSAY*" /label="yitF CDS" gene complement(1093305..1094420) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /label="yitF gene" downshifts complement(1093334) /Source="Nicolas_upshifts" /id="D595" /incds=0 /nref=11 /ntot=42 /MaxReadThrough="1.81817" /MaxDrop="4.27426" /score="13.5713023" /energy="-14.5" /TU="NA" /idTUdmin="U883" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1094429..1095697) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 14762009, 15109717, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388979.1" /db_xref="EnsemblGenomes-Gn:BSU10980" /db_xref="EnsemblGenomes-Tr:CAB12938" /db_xref="GOA:Q796Q1" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13112" /db_xref="UniProtKB/Swiss-Prot:Q796Q1" /translation="MESSKQNNGMTIVAIGSIPLILTLGNSMLIPILPKMKSELHLSQ FQVSLVITVFSLIAAFAIPIVGYLADRFSRKVIIIPCLILYGAGGLLAGFAAGFFDNA YPWVMAGRALQGIGAAGTGPIAMALTGDLFKGAQESKVLGLVEASNGMGKVLSPIIGS LIALLVWYGAFFAFPVFCIISIVLTWIFIKEKKKEKEPPPIGQYAKGLLSVFKHEGRW LFTAYLAGATCLFTLFGILFYLSDVLEKTYDTDGVKKGLILAIPLLVMCVTSYTTGSK IGQKQSLMKKLIVLGLAFMTVSYAALSFIENLVLFISVLVLSSIGSGLVLPCVNSFIT GAVGKERRGFVTSLYGSVRFLGVAIGPPIFGRLMQWSRPGMFLSIAGLTLVVGILVMM LIHVKQNNEETKEKEDPKMAGNRLQPAEER*" /label="yitG CDS" gene complement(1094429..1095697) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /label="yitG gene" promotor_-10 complement(1095723..1095734) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1095732) /Source="Nicolas_upshifts" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1095748..1095754) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1095809..1096657) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388980.1" /db_xref="EnsemblGenomes-Gn:BSU10990" /db_xref="EnsemblGenomes-Tr:CAB12939" /db_xref="GOA:O06743" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13113" /db_xref="UniProtKB/Swiss-Prot:O06743" /translation="MDVVDELIKLHEEHVSGLLRLCGQAGWPDYGEQELKLLVQQGRF FGYQNVSGDIISCIGLFLFGRLTSIGLVIVDKEYQRLGLGRRMVNACITQTDENTAIR LCATKEGLPLYEKAGFHTAGSVRKYSCHSFQPYTKKLDAELTSFREQDFHDLTAADLA AFGGDRSNLLQQLISASCECIIARNQDGQLIGYGLSVQTPANLKFGPIIAPSSDVAAQ IITRLAAGKQGPMRIDIPSEHTSLHDSLIEMGFHKDDEPPILFYQKKAPIQNGHLYAL ISQALG*" /label="yitH CDS" gene complement(1095809..1096657) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /label="yitH gene" downshifts complement(1095820) /Source="Nicolas_upshifts" /id="D596" /incds=0 /nref=34 /ntot=209 /MaxReadThrough="2.34135" /MaxDrop="3.51892" /score="14.8688564" /energy="-11.7" /TU="NA" /idTUdmin="U884" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1096662..1097111) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388981.2" /db_xref="EnsemblGenomes-Gn:BSU11000" /db_xref="EnsemblGenomes-Tr:CAB12940" /db_xref="GOA:O06744" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13114" /db_xref="UniProtKB/Swiss-Prot:O06744" /translation="MLEVKTISVEDTYEIRHRILRPHQSIEQCKYKEDHAEGSFHLGV FYDGTLISIASFSPQSQPLLTEASAYRLRGMATLEGYRDQKAGSTLIKHAEHKLAESG VQAVWCNARHHVKGYYAKLGWKELGEPFDIPGIGNHIVMYKTLRTSR*" /label="yitI CDS" gene complement(1096662..1097111) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /label="yitI gene" promotor_-10 complement(1097132..1097151) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1097146) /Source="Nicolas_upshifts" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1097167..1097168) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1097201..1099039) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /EC_number="1.5.1.20" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 17264075, 20421295, 20951706, 26233166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional homocysteine S-methyltransferase using (R,S)AdoMet and methylenetetrahydrofolate reductase [NAD(P)H]" /protein_id="NP_388982.1" /db_xref="EnsemblGenomes-Gn:BSU11010" /db_xref="EnsemblGenomes-Tr:CAB12941" /db_xref="GOA:O06745" /db_xref="InterPro:IPR003171" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR029041" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG13115" /db_xref="UniProtKB/Swiss-Prot:O06745" /translation="MGLLEDLQRQVLIGDGAMGTLLYSYGIDRCFEELNISKPEEIQR IHKAYVEAGANIIQTNTYGANYIKLSRHGLEDDIKKMNQEAVKIARASAGDAYVLGTM GGIRTFNKNAYSLDEIKRSFREQLYLLLHEEPDGLLLETYYDLEEAREVLKIARKETD LPIMLNVSMHEQGVLQDGTPLSDALRSIADLGADIVGINCRLGPYHMIEALSEVPIFD DVFLSVYPNSSLPSLEEGRLVYETDDTYFQNSASEFRKQGARIIGGCCGTTPNHIRAM AEAVGGLAPITEKEVKTRAKEFISVHHERTEPGLDEIAAKKRSIIVELDPPKKLSFDK FLSAAAELKEAGIDALTLADNSLATPRISNVACGALVKQQLDMRSLVHITCRDRNIIG LQSHLMGLDTLGLNDVLAITGDPSKIGDFPGATSVYDLTSFDLIRLIKQFNEGLSLSG KPLGKKTNFSVAAAFNPNVRHLDKAVKRLEKKIDCGADYFVSQPVYSEQQLVDIHNET KHLKTPIYIGIMPLTSSRNAEFIHNEIPGIKLSDTIREKMAHAGEDKEKQKAEGLAIA RSLLDTACELFNGIYLITPFLRSDLTAELTSYIQQKDEQRQNIFLH*" /label="samT CDS" gene complement(1097201..1099039) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /label="samT gene" downshifts complement(1097228) /Source="Nicolas_upshifts" /id="D597" /incds=0 /nref=14 /ntot=91 /MaxReadThrough="3.04289" /MaxDrop="4.13744" /score="12.9586126" /energy="-16.2" /TU="U885" /idTUdmin="U885" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts complement(1099121) /Source="Nicolas_upshifts" /id="D598" /incds=0 /nref=47 /ntot=128 /MaxReadThrough="8.00128" /MaxDrop="5.61487" /score="22.3754155" /energy="-7.3" /TU="U885,U887" /idTUdmin="U887" /TUdmin="-1079" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1099129..1099246) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswK RNA" gene complement(1099129..1099246) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /label="mswK gene" promotor_-10 complement(1099298..1099317) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" upshifts complement(1099312) /Source="Nicolas_upshifts" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="upshifts" promotor_-35 complement(1099332..1099339) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS complement(1099353..1099844) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12943362, 25329577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA or cyclic d-GMP binding protein" /protein_id="NP_388983.1" /db_xref="EnsemblGenomes-Gn:BSU11020" /db_xref="EnsemblGenomes-Tr:CAB12942" /db_xref="InterPro:IPR007551" /db_xref="InterPro:IPR035570" /db_xref="InterPro:IPR035571" /db_xref="InterPro:IPR036183" /db_xref="SubtiList:BG13116" /db_xref="UniProtKB/Swiss-Prot:O06746" /translation="MAKESSFDIVSKVELPEVQNAIQIALKEISTRYDFKGSKSDISL DKEELVLVSDDEFKLSQLKDVLVSKLIKRNVPTKNIDYGKVENASGGTVRQRAKLVQG IDKDNAKKINTIIKNSGLKVKSQVQDDQVRVTGKNKDDLQQIISAVRGADLPIDVQFI NFR*" /label="yitK CDS" gene complement(1099353..1099844) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /label="yitK gene" promotor_-35 1099862..1099865 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1099868..1099887) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" promotor_-10 1099880..1099899 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1099881 /Source="Nicolas_upshifts" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1099886) /Source="Nicolas_upshifts" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="upshifts" promotor_-35 complement(1099902..1099909) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS 1099943..1100839 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20399190; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA-binding protein" /protein_id="NP_388984.1" /db_xref="EnsemblGenomes-Gn:BSU11030" /db_xref="EnsemblGenomes-Tr:CAB12943" /db_xref="GOA:O06747" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014464" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13117" /db_xref="UniProtKB/Swiss-Prot:O06747" /translation="MLTKSAENKRNRKDDSMRPGQQLTLSIDHQTDFGYFLTDGEDTI LLHNSEMTEDIEDRDEVEVFIYVDQQERLAATMKIPIISADEYGWVEVVDKVEDMGVF VDVGLSKDALVATEHLPPYEDVWPQKGDKLYCMLKVTNRGRMFAKPAPEDIISELFTD ASEDLMNKELTGTVYRLIASGSFVITDDGIRCFIHPSERKEEPRLGSRVTGRVIQVKE DGSVNLSLLPRKQDAMSVDAECILTYMRMRNGAMPYSDKSQPDDIRERFNMSKAAFKR ALGHLMKNGKVYQENGWTYEKK*" /label="yitL CDS" gene 1099943..1100839 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /label="yitL gene" downshifts 1100826 /Source="Nicolas_upshifts" /id="D599" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="1.78082" /MaxDrop="6.73614" /score="40.361011" /energy="-21.5" /TU="NA" /idTUdmin="U886" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1100892..1101476) /gene="yitM" /locus_tag="BSU_11040" /old_locus_tag="BSU11040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11557812" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388985.1" /db_xref="EnsemblGenomes-Gn:BSU11040" /db_xref="EnsemblGenomes-Tr:CAB12944" /db_xref="GOA:O06748" /db_xref="InterPro:IPR023888" /db_xref="SubtiList:BG13118" /db_xref="UniProtKB/Swiss-Prot:O06748" /translation="MKKAFLVFLSVVLVTTVFLVKQQESVAQAKQLEYSGEEIFKGFV FAQGEVGKQLPEVFNKAMTDKLNTKQAKAFANQVVADIKKEDADFFDNLKKAVYSKDA LKVDELLKKAGQIVEEKVEAAKEIAASKDDTSRVQAELVNTVDTANYFYYVSYVAAAG ALILIILAIDITPIAISDNVDREMAIRTLVDELN*" /label="yitM CDS" gene complement(1100892..1101476) /gene="yitM" /locus_tag="BSU_11040" /old_locus_tag="BSU11040" /label="yitM gene" downshifts complement(1100902) /Source="Nicolas_upshifts" /id="D600" /incds=0 /nref=68 /ntot=158 /MaxReadThrough="1.3386" /MaxDrop="7.40935" /score="10.143892" /energy="-21.5" /TU="NA" /idTUdmin="U888" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1101473..1102402) /gene="yitO" /locus_tag="BSU_11055" /old_locus_tag="BSU11055" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11557812, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with HTTM domain" /protein_id="NP_388987.2" /db_xref="EnsemblGenomes-Gn:BSU11055" /db_xref="EnsemblGenomes-Tr:CAB12946" /db_xref="GOA:O06750" /db_xref="InterPro:IPR011020" /db_xref="InterPro:IPR023894" /db_xref="SubtiList:BG13120" /db_xref="UniProtKB/Swiss-Prot:O06750" /translation="MLENIKQTITRWDERNPWTNVYGLARSIIALSSLLTLLINHPSL IMKPASGISSYPACKMNLSLFCLGENNYMMLNLFRWVCIAILVLVVIGWRPRITGVLH WYVSYSLQSSLIVIDGGEQAAAVMTFLLLPITLTDPRKWHWSTRPIEGKRTLGKITAF ISYFVIRIQVAVLYFHSTVAKLSQQEWVDGTAVYYFAQEKTIGFNGFFQALTKPIVTS PFVVIPTWGTLLVQIVIFAALFAPKKHWRLILIIAVFMHEIFAVMLGLISFSIIMAGI LILYLTPIDSTIQFTYIRRLLWNKKHKKGEVSV*" /label="yitO CDS" gene complement(1101473..1102402) /gene="yitO" /locus_tag="BSU_11055" /old_locus_tag="BSU11055" /label="yitO gene" upshifts complement(1101560) /Source="Nicolas_upshifts" /id="U888" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.232767232767233" /psig="0.63936063936064" /xcortree=2974 /SigmaFactorBS="agtcatgctgggcctcatcagtttttcgattatcatggccgg cattttgatattgtatctcaCtcctatcgattccacgattcaatttacatatattcgc a" /listShort="yitM" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1102387..1102923) /gene="yitP" /locus_tag="BSU_11070" /old_locus_tag="BSU11070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 6289325, 11557812" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388988.1" /db_xref="EnsemblGenomes-Gn:BSU11070" /db_xref="EnsemblGenomes-Tr:CAB12947" /db_xref="GOA:O06751" /db_xref="InterPro:IPR023902" /db_xref="SubtiList:BG13121" /db_xref="UniProtKB/Swiss-Prot:O06751" /translation="MQKSISFFVIFSILWGSLFLFSIIGSLGTTPIPLTKDSKFLMSS ILPQGWGFFSKNPRDTAIGLYEAENASAKVRWPNMRADNLFGLYRYGRSQGVEMGVIY SQVGKEQWTACKEKDLGACKSKAKTVQLKTPAPRPLLCGSYYLTKEDIVPWSYSKYTP SSYQVKSIVKVVISCSKT*" /label="yitP CDS" gene complement(1102387..1102923) /gene="yitP" /locus_tag="BSU_11070" /old_locus_tag="BSU11070" /label="yitP gene" promotor_-10 complement(1102959..1102978) /Source="Nicolas_upshift_promotors" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1102973) /Source="Nicolas_upshifts" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1102993..1102996) /Source="Nicolas_upshift_promotors" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1103064..1103071 /Source="Nicolas_upshift_promotors" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1103086..1103105 /Source="Nicolas_upshift_promotors" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1103089 /Source="Nicolas_upshifts" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="upshifts" CDS 1103101..1103448 /gene="yizB" /locus_tag="BSU_11079" /old_locus_tag="BSU11079" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097701.1" /db_xref="EnsemblGenomes-Gn:BSU11079" /db_xref="EnsemblGenomes-Tr:CAX52589" /db_xref="GOA:C0H3Y4" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Y4" /translation="MKTNQVNDRWIVQFRKGIFELAILSLLRSKPMYGYELTSSLKTT SALAISEGAIYPILKRMTEKGWIEFFWEDSLDGPKRKYYKMTQKGEEMLKERLEKYLE THQALLSLSGDLL*" /label="yizB CDS" gene 1103101..1103448 /gene="yizB" /locus_tag="BSU_11079" /old_locus_tag="BSU11079" /label="yizB gene" CDS 1103445..1104032 /gene="yitQ" /locus_tag="BSU_11080" /old_locus_tag="BSU11080" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23504016" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388989.2" /db_xref="EnsemblGenomes-Gn:BSU11080" /db_xref="EnsemblGenomes-Tr:CAB12948" /db_xref="GOA:O06752" /db_xref="SubtiList:BG13122" /db_xref="UniProtKB/Swiss-Prot:O06752" /translation="MNGQLIIDRYMEELNAELANMPDVERENAIDELKGHITAFVQDR IKAGLSEEELQEAVESEFSHPKELAELMMGDGGETKRRRSLLGKSWISVLLIVTIIAL PLLPSDFRHLPLAVYLMVLAGYVWKRKKLVMFAGVRKNKMRSQKEIVKISRVGAVYLL FLAVVLLLSPFLNALVVLLLIAVSCAAFFLFLNIK*" /label="yitQ CDS" gene 1103445..1104032 /gene="yitQ" /locus_tag="BSU_11080" /old_locus_tag="BSU11080" /label="yitQ gene" CDS 1104052..1104345 /gene="yitR" /locus_tag="BSU_11090" /old_locus_tag="BSU11090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388990.1" /db_xref="EnsemblGenomes-Gn:BSU11090" /db_xref="EnsemblGenomes-Tr:CAB12949" /db_xref="GOA:O06753" /db_xref="InterPro:IPR017259" /db_xref="SubtiList:BG13123" /db_xref="UniProtKB/Swiss-Prot:O06753" /translation="MEISINYLLIVIALLFFVVAYFVGIKKQTWMLAGFNEARIRDKD RLARIAGYFFLNSGLFILLNSFISFQGQEQLIPPLILAYGAGVIIYVNKKLVE*" /label="yitR CDS" gene 1104052..1104345 /gene="yitR" /locus_tag="BSU_11090" /old_locus_tag="BSU11090" /label="yitR gene" downshifts 1104325 /Source="Nicolas_upshifts" /id="D601" /incds=0 /nref=119 /ntot=240 /MaxReadThrough="1.96008" /MaxDrop="5.72545" /score="2.11183863" /energy="-12.6" /TU="NA" /idTUdmin="U890" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1104369 /Source="Nicolas_upshifts" /id="D602" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="0.34732" /MaxDrop="3.0285" /score="2.11183863" /energy="-12.6" /TU="NA" /idTUdmin="U890" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS 1104481..1106097 /gene="nprB" /locus_tag="BSU_11100" /old_locus_tag="BSU11100" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1917867, 16672610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1917867, 16672610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular neutral protease B" /protein_id="NP_388991.1" /db_xref="EnsemblGenomes-Gn:BSU11100" /db_xref="EnsemblGenomes-Tr:CAB12950" /db_xref="GOA:P39899" /db_xref="InterPro:IPR001570" /db_xref="InterPro:IPR011096" /db_xref="InterPro:IPR013856" /db_xref="InterPro:IPR023612" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG10691" /db_xref="UniProtKB/Swiss-Prot:P39899" /translation="MRNLTKTSLLLAGLCTAAQMVFVTHASAEESIEYDHTYQTPSYI IEKSPQKPVQNTTQKESLFSYLDKHQTQFKLKGNANSHFRVSKTIKDPKTKQTFFKLT EVYKGIPIYGFEQAVAMKENKQVKSFFGKVHPQIKDVSVTPSISEKKAIHTARRELEA SIGKIEYLDGEPKGELYIYPHDGEYDLAYLVRLSTSEPEPGYWHYFIDAKNGKVIESF NAIHEAAGTGIGVSGDEKSFDVTEQNGRFYLADETRGKGINTFDAKNLNETLFTLLSQ LIGYTGKEIVSGTSVFNEPAAVDAHANAQAVYDYYSKTFGRDSFDQNGARITSTVHVG KQWNNAAWNGVQMVYGDGDGSKFKPLSGSLDIVAHEITHAVTQYSAGLLYQGEPGALN ESISDIMGAMADRDDWEIGEDVYTPGIAGDSLRSLEDPSKQGNPDHYSNRYTGTEDYG GVHINSSIHNKAAYLLAEGGVHHGVQVEGIGREASEQIYYRALTYYVTASTDFSMMKQ AAIEAANDLYGEGSKQSASVEKAYEAVGIL*" /label="nprB CDS" gene 1104481..1106097 /gene="nprB" /locus_tag="BSU_11100" /old_locus_tag="BSU11100" /label="nprB gene" downshifts 1106085 /Source="Nicolas_upshifts" /id="D603" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="0.278770000000001" /MaxDrop="3.08544" /score="2.81939887" /energy="-8.6" /TU="NA" /idTUdmin="U890" /TUdmin=1760 /isTUend="FALSE" /label="downshifts" CDS complement(1106144..1106995) /gene="fakBB" /locus_tag="BSU_11110" /old_locus_tag="BSU11110" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit B" /protein_id="NP_388992.1" /db_xref="EnsemblGenomes-Gn:BSU11110" /db_xref="EnsemblGenomes-Tr:CAB12951" /db_xref="GOA:P70945" /db_xref="InterPro:IPR003797" /db_xref="SubtiList:BG12244" /db_xref="UniProtKB/Swiss-Prot:P70945" /translation="MTVHLIADSATDLPRSYFEEKGIGFIPLRVSLGDKEFEDAVTIH ADQIFEAMQNGETPKTSQASPQTIKNVFLQYAETGDPALYIAFSSGLSGTYQTAVMIA NEVKEEFPDFDLRVIDSKCASLGYGLAVRHAADLCINGNTIQEIETSVKNFCSQLEHI FTVDDLTYLARGGRISKTSAFVGGLLNIKPLLQMEDGKLVPLEKIRGQKKLFKRIIEL MKERGDDWSNQTVGISYAANKEKATDMKHLIEEAFKPKEIIMHPISSAIGSHAGPGTL AIFFLRK*" /label="fakBB CDS" gene complement(1106144..1106995) /gene="fakBB" /locus_tag="BSU_11110" /old_locus_tag="BSU11110" /label="fakBB gene" downshifts complement(1106161) /Source="Nicolas_upshifts" /id="D604" /incds=0 /nref=209 /ntot=263 /MaxReadThrough="0.727580000000001" /MaxDrop="6.86927" /score="-1.24586831" /energy="-7.7" /TU="NA" /idTUdmin="U892" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1106542..1106549 /Source="Nicolas_upshift_promotors" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1106564..1106583 /Source="Nicolas_upshift_promotors" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1106569..1107094 /Source="Nicolas_S_feature" /locus_tag="new_1188125_1188650" /HighExp="G180, Paraq, G135, G150, Oxctl, C30, H2O2, LBGstat, LBGexp, Lbexp" /AntisenseName="yitS" /AntisenseCor="-0.45830528686941202" /AntisenseRegPval="-14.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S395" upshifts 1106571 /Source="Nicolas_upshifts" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1107036..1107055) /Source="Nicolas_upshift_promotors" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1107059) /Source="Nicolas_upshifts" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1107073..1107078 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1107093..1107111 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1107096 /Source="Nicolas_upshifts" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="upshifts" CDS 1107133..1107975 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23419162, 23824080; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388993.1" /db_xref="EnsemblGenomes-Gn:BSU11120" /db_xref="EnsemblGenomes-Tr:CAB12952" /db_xref="GOA:P39803" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG10850" /db_xref="UniProtKB/Swiss-Prot:P39803" /translation="MVLDQTKKLLIVIIGALLNAAGLNLFLIPADVYASGFTGVAQLL SSVVDQYAPFYISTGTLLFLLNIPVGILGWLKVGKSFTVYSILSVALTTLFMGILPET SLSHDILLNAVFGGVISAVGIGLTLKYGASTGGLDIVAMVLAKWKDKPVGTYFFILNG IIILTAGLLQGWEKALYTLVTLYVTTRVIDAIHTRHMKLTAMIVTKKADEIKEAIYGK MVRGITTVPAKGAFTNEQKEMMIIVITRYELYDLEKIVKEVDPKAFTNIVQTTGIFGF FRKD*" /label="yitT CDS" gene 1107133..1107975 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /label="yitT gene" promotor_-35 1107628..1107636 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1107647..1107665 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1107647 /Source="Nicolas_upshifts" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="upshifts" S_feature 1107976..1108089 /Source="Nicolas_S_feature" /locus_tag="new_1189532_1189645" /HighExp="Etha, S8, Sw, M9-stat, S7, BC, Gly, S6, Salt, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigB, SigA" /TUshortPSig="0.968, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S396" CDS 1108090..1108449 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8226659, 24555072" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226659, 24555072; Product type f: factor" /codon_start=1 /transl_table=11 /product="intracellular proteinase inhibitor BsuPI" /protein_id="NP_388994.1" /db_xref="EnsemblGenomes-Gn:BSU11130" /db_xref="EnsemblGenomes-Tr:CAB12953" /db_xref="GOA:P39804" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR020481" /db_xref="PDB:3ISY" /db_xref="SubtiList:BG10852" /db_xref="UniProtKB/Swiss-Prot:P39804" /translation="MENQEVVLSIDAIQEPEQIKFNMSLKNQSERAIEFQFSTGQKFE LVVYDSEHKERYRYSKEKMFTQAFQNLTLESGETYDFSDVWKEVPEPGTYEVKVTFKG RAENLKQVQAVQQFEVK*" /label="ipi CDS" gene 1108090..1108449 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /label="ipi gene" downshifts 1108438 /Source="Nicolas_upshifts" /id="D605" /incds=0 /nref=34 /ntot=224 /MaxReadThrough="1.36729" /MaxDrop="5.6855" /score="43.7575824" /energy="-15.6" /TU="NA" /idTUdmin="U893" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1108480..1108677) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; genus orphan" /protein_id="YP_003097702.1" /db_xref="EnsemblGenomes-Gn:BSU11139" /db_xref="EnsemblGenomes-Tr:CAX52590" /db_xref="InterPro:IPR024217" /db_xref="UniProtKB/Swiss-Prot:C0H3Y5" /translation="MRNELFQQAKSFVQQAVMVTNGFEEGDQEQAILRAKNAVSSAYA NSTDAERQQLHQFQNQLDKLQ*" /label="yizC CDS" gene complement(1108480..1108677) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /label="yizC gene" downshifts complement(1108493) /Source="Nicolas_upshifts" /id="D606" /incds=0 /nref=150 /ntot=257 /MaxReadThrough="1.42333" /MaxDrop="8.284" /score="2.35557074" /energy="-17.3" /TU="NA" /idTUdmin="U895" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1108678..1108874) /Source="Nicolas_S_feature" /locus_tag="new_1190234_1190430_c" /HighExp="S8, S6, S5, S7, nit, ferm, BT, G/S, Pyr, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99834599999999996" /TUshortSig="SigGF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S397" upshifts complement(1108874) /Source="Nicolas_upshifts" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1108876..1108887) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1108902..1108908) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1108934..1109746) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25012491, 26316208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase (promiscuous)" /protein_id="NP_388995.1" /db_xref="EnsemblGenomes-Gn:BSU11140" /db_xref="EnsemblGenomes-Tr:CAB12954" /db_xref="GOA:P70947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12245" /db_xref="UniProtKB/Swiss-Prot:P70947" /translation="METKPYLIALDLDGTLLKDDKTISENTLHTIQRLKDDGHYVCIS TGRPYRSSSMYYQQMELTTPIVNFNGAFVHHPQDDSWGRYHTSLPLDVVKQLVDISES YNVHNVLAEVIDDVYFHYHDEHLIDAFNMNTTNVTVGDLRENLGEDVTSVLIHAKEED VPAIRSYLSDVHAEVIDHRRWAAPWHVIEIIKSGMNKAVGLQKISDYYGVPRERIIAF GDEDNDLEMLEFAGCGVAMGNGIDAVKQIANRTTATNEEDGVARFLKEYFSL*" /label="ribZC CDS" gene complement(1108934..1109746) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /label="ribZC gene" promotor_-10 complement(1109784..1109803) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1109804..1109811 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1109804) /Source="Nicolas_upshifts" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1109817..1109824) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1109823..1109842 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1109825 /Source="Nicolas_upshifts" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1109867..1110634 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28293230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxylesterase" /protein_id="NP_388996.1" /db_xref="EnsemblGenomes-Gn:BSU11150" /db_xref="EnsemblGenomes-Tr:CAB12955" /db_xref="GOA:P70948" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12246" /db_xref="UniProtKB/Swiss-Prot:P70948" /translation="MIQIENQTVSGIPFLHIVKEENRHRAVPLVIFIHGFTSAKEHNL HIAYLLAEKGFRAVLPEALHHGERGEEMAVEELAGHFWDIVLNEIEEIGVLKNHFEKE GLIDGGRIGLAGTSMGGITTLGALTAYDWIKAGVSLMGSPNYVELFQQQIDHIQSQGI EIDVPEEKVQQLMKRLELRDLSLQPEKLQQRPLLFWHGAKDKVVPYAPTRKFYDTIKS HYSEQPERLQFIGDENADHKVPRAAVLKTIEWFETYL*" /label="yitV CDS" gene 1109867..1110634 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /label="yitV gene" promotor_-35 1110643..1110649 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1110663 /Source="Nicolas_upshifts" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1110664..1110683 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1110698..1111006 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9209063; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein involved in Fe-S cluster assembly, PaaD-like" /protein_id="NP_388997.1" /db_xref="EnsemblGenomes-Gn:BSU11160" /db_xref="EnsemblGenomes-Tr:CAB12956" /db_xref="InterPro:IPR002744" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG12247" /db_xref="UniProtKB/Swiss-Prot:P70949" /translation="MEEALKENIMGALEQVVDPELGVDIVNLGLVYDVDMDEDGLTHI TMTLTSMGCPLAPIIVDEVKKALADLPEVKDTEVHIVWNPPWTRDKMSRYAKIALGIQ *" /label="yitW CDS" gene 1110698..1111006 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /label="yitW gene" downshifts 1110991 /Source="Nicolas_upshifts" /id="D607" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="5.65659" /MaxDrop="4.5598" /score="14.9971829" /energy="-14.7" /TU="U897,U898" /idTUdmin="U897" /TUdmin="-2244" /isTUend="FALSE" /label="downshifts" S_feature 1111036..1111301 /Source="Nicolas_S_feature" /locus_tag="new_1192592_1192857" /HighExp="Etha, dia15, dia5, H2O2, LoTm, Salt, S6, Diami, S8, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S398" CDS 1111302..1112732 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16956367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN/FAD-binding oxidoreductase" /protein_id="NP_388999.3" /db_xref="EnsemblGenomes-Gn:BSU11170" /db_xref="EnsemblGenomes-Tr:CAB12958" /db_xref="GOA:Q796P5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12249" /db_xref="UniProtKB/Swiss-Prot:Q796P5" /translation="MKKKLLAFALCTGAYAALFAYSVNSEQKTATSEMTDVSRLMPVK IKQTVKGQEEEMLIDTVKEANRKNIKISIAGAQHSMGGHTYYEDGIVLDMTGYNKILS LDQEKKTIRVQSGATWNDIQKYVNPYGLAVKVMQSQNIFTIGGSLSANAHGRDIRYGS LIDTVKSFRLLKADGMIITVTPKDDLFTAVIGGYGLFGVILDVTLELTDDELYVMKTE KMNYSTYSDYFSKHVKGNPDVRMHLARISTAKKGFLKDMYVTNYVLANHQDQLSSYSE LKEDEYTGATKFALGLSRRYEWGRNWLWDTQQSYFLSQNGTEISRNNVMRSESKFLEY ENNDNTDVLQEYFVPVKEYGSYIDDLRQTLSDEDLNLLNITIRYVQKNEKADLSYAKD DMFSLVLLINEGFSKEDQADTARIIRRMTDVAIKHGGSYYLPYMTYQTKAQMRQAYPK SEAFFQKKRTYDPDERFMNYFYQRYK*" /label="yitY CDS" gene 1111302..1112732 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /label="yitY gene" CDS 1112777..1113271 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transport protein" /protein_id="NP_389000.1" /db_xref="EnsemblGenomes-Gn:BSU11180" /db_xref="EnsemblGenomes-Tr:CAB12959" /db_xref="GOA:P70952" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12250" /db_xref="UniProtKB/Swiss-Prot:P70952" /translation="MFFASSLIFPFYILFVKNIGSSYTQFGFSYGLFGLSGALIYPLL GRLSERFDSRYFLLLNSWGMAVLLLYVPHIGSVVQVYIVQVLLGLFGAMQKHGEKVLI ANFTDSGERGKKIGNYHFWTAVFSAAAIMLGGFLADFFTVQMIFYASSILYFLSGLMM MKTG*" /label="yitZ CDS" gene 1112777..1113271 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /label="yitZ gene" downshifts 1113235 /Source="Nicolas_upshifts" /id="D608" /incds=0 /nref=49 /ntot=208 /MaxReadThrough="1.74762" /MaxDrop="4.22077" /score="34.1294744" /energy="-13.2" /TU="NA" /idTUdmin="U897" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1113409..1113416 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1113415 /Source="Nicolas_upshifts" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1113430..1113449 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1113478..1114515 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /EC_number="1.2.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate gamma-semialdehyde dehydrogenase" /protein_id="NP_389001.2" /db_xref="EnsemblGenomes-Gn:BSU11190" /db_xref="EnsemblGenomes-Tr:CAB12960" /db_xref="GOA:P23715" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR000706" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR023013" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10191" /db_xref="UniProtKB/Swiss-Prot:P23715" /translation="MKIGIVGATGYGGTELVRILSHHPHAEECILYSSSGEGNVYSEG YPHLTGLADQQLKPIDMNTIKHEIDIMFLAAPPGVSSELTPKLADAGITVIDLSGDLR IKEPAEYEKWYKRTAAPKAVIQEAVYGLAELNQLQIQQAKLIANPGCFPTAVLLGLAP LAQKKLLDESFVIVDAKTGVSGAGRKASMGTHFSELNDNFKIYKVNEHQHTPEIEQAL NEWQPGLGPITFSAHLVPMTRGIMATMYTRLTCDLTADDLHDLYSEFYQDSYFVRVRP KGQYPQTKEVYGSNFCDIAVTLDERTNRVTIVSVIDNLMKGAAGQAVQNFNLMNGWNE ETGLTITPIYP*" /label="argC CDS" gene 1113478..1114515 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /label="argC gene" CDS 1114535..1115755 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /EC_number="2.3.1.1" /EC_number="2.3.1.35" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8025667, 10931207, 16409639, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8025667, 10931207, 16409639, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine acetyltransferase; amino-acid acetyltransferase" /protein_id="NP_389002.2" /db_xref="EnsemblGenomes-Gn:BSU11200" /db_xref="EnsemblGenomes-Tr:CAB12961" /db_xref="GOA:P36843" /db_xref="InterPro:IPR002813" /db_xref="InterPro:IPR016117" /db_xref="SubtiList:BG10192" /db_xref="UniProtKB/Swiss-Prot:P36843" /translation="MIQLSEDQIVKVTGDVSSPKGFQAKGVHCGLRYSKKDLGVIISE TPAVSAAVYTQSHFQAAPIKVTQDSLKHGPTLKAVIVNSAIANACTGEQGLKDAYTMR ESFASQLGIEPELVAVSSTGVIGEHLDMEKIHAGIELLKETPAGSGDFEEAILTTDTV IKQTCYELAIGGKTVTIGGAAKGSGMIHPNMATMLGFVTTDAAIEEKALQKALREITD VSFNQITVDGETSTNDMVLVMANGCAENECLTEDHPDWPVFKKALLLTCEDLAKEIAR DGEGATKLIEAQVQGAKNNLDANVIAKKIVGSNLVKTAVYGTDANWGRIIGAIGHSAA QVTAEEVEVYLGGQCLFKNNEPQPFSESIAKEYLEGDEITIVIKMAEGDGNGRAWGCD LTYDYIKINASYRT*" /label="argJ CDS" gene 1114535..1115755 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /label="argJ gene" CDS 1115770..1116546 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /EC_number="2.7.2.8" /experiment="publication(s) with functional evidences, PMID:3005232, 8473852" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3005232, 8473852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate 5-phosphotransferase (acetylglutamate kinase)" /protein_id="NP_389003.1" /db_xref="EnsemblGenomes-Gn:BSU11210" /db_xref="EnsemblGenomes-Tr:CAB12962" /db_xref="GOA:P68729" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR004662" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10193" /db_xref="UniProtKB/Swiss-Prot:P68729" /translation="MKKTIVFKCGGSVIRELSEEFYQNLKELRASGWKLAIVHGGGPE ITNMLKRLNIKTEFSGGQRKTTKPVLEVAEMVLSGSVNKFFVAELAKHGLRAAGISGK DGGLLEADYLDPETYGEVGEIKKVDASMVNALMENGIIPVIAPLSMTSDCKTLNVNAD LAASAVAGALEADKLMFVTDVDGIMKEKQRLDVLTPKEIQMLIKQEVITGGMIPKVNS ALSALSDQVSEVMIVNGKGSFFAEQTFQGTKIVKAKEAVS*" /label="argB CDS" gene 1115770..1116546 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /label="argB gene" CDS 1116543..1117700 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /EC_number="2.6.1.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17012789; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylornithine aminotransferase" /protein_id="NP_389004.2" /db_xref="EnsemblGenomes-Gn:BSU11220" /db_xref="EnsemblGenomes-Tr:CAB12963" /db_xref="GOA:P36839" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10194" /db_xref="UniProtKB/Swiss-Prot:P36839" /translation="MSSLFQTYGRWDIDIKKAKGTYVEDQNGKTYLDFIQGIAVSNLG HCHEAVTEAVKKQLDSVWHVSNLFQNSLQEQAAQKLAAHSAGDLVFFCNSGAEANEGA IKLARKATGKTKIITFLQSFHGRTYAGMAATGQDKIKTGFGPMLGGFHYLPYNDPSAF KALGEEGDIAAVMLETVQGEGGVNPASAEFLSAVQSFCKEKQALLIIDEIQTGIGRTG KGFAYEHFGLSPDIITVAKGLGNGFPVGAVIGKKQLGEAFTPGSHGTTFGGNMLAMAA VNATLQIVFQPDFLQEAADKGAFLKEQLEAELKSPFVKQIRGKGLMLGIECDGPVADI IAELQTLGLLVLPAGPNVIRLLPPLTVTKDEIAEAVSKLKQAIAHHSAVNQ*" /label="argD CDS" gene 1116543..1117700 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /label="argD gene" CDS 1117771..1118826 /gene="carA" /locus_tag="Delta6_BSU_11230_SNPvariant" /old_locus_tag="BSU_11230" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 230177, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 230177, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(small subunit)" /protein_id="NP_389005.2" /db_xref="EnsemblGenomes-Gn:BSU11230" /db_xref="EnsemblGenomes-Tr:CAB12964" /db_xref="GOA:P36838" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10195" /db_xref="UniProtKB/Swiss-Prot:P36838" /modified_by="User" /translation="MEGYLVLEDGTSFSGELDGHENCTGEAVFFTGMTGYQEVLTDPS YKGQIIVFTYPLIGNYGINEKDFESKKPQVKAAVVYEACDHFSHYEAVYSLKEYLQKW NIPLLTHVDTRAVVKKIRANGTMGATVTASKEGAEIALQPENVAEQASAQEISTFGDG NKHIALIDFGYKKSIASSLVKRGCKVTVVPYQQMEAVYNIKPDGLSNGPGDPKAIQPY LGKIKSIISRFPTLGICLGHQLIALAFGGNTFKLPFGHRGANHPVIDRKTKRVFMTSQ NHSYVVDEQSINEEELTIRFHHVNDTSVEGLAHKKLPVMSVQFHPEAHPGPAESEWIF DDYLKNVIPARREIAHA*" /label="Delta6_BSU_11230_SNPvariant" gene 1117771..1118826 /gene="carA" /locus_tag="Delta6_BSU_11230_SNPvariant" /old_locus_tag="BSU_11230" /modified_by="User" /label="Delta6_BSU_11230_SNPvariant" Polymorphism join(1118381,1118382) /Source="geneious" /ID="SNP_BsDelta6_1199938_1199943" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=6 /Amino_Acid_Change="GIV -> G" /CDS_Position=612 /Change="-AATTGT" /Codon_Change="GGA,ATT,GTG -> GGG" /Coverage="183 -> 185" /locus_tag="BSU_11230" /Protein_Effect="Deletion" /Reference_Frequency /Reference_Nucleotides="AATTGT" /Variant_Nucleotides /Variant_P_Value=0 /Variant_Raw_Frequency=174 /comment="Delta6_BSU_11230_SNPvariant" / /modified_by="User" /label="Polymorphism_Delta6" misc_feature complement(1118660..1118679) /Source="Nicolas_upshift_promotors" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1118670) /Source="Nicolas_upshifts" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1118819..1121911 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(large subunit)" /protein_id="NP_389006.3" /db_xref="EnsemblGenomes-Gn:BSU11240" /db_xref="EnsemblGenomes-Tr:CAB12965" /db_xref="GOA:P18185" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR036897" /db_xref="SubtiList:BG10196" /db_xref="UniProtKB/Swiss-Prot:P18185" /translation="MPKDTSISSILVIGSGPIIIGQAAEFDYSGTQGCIALKEEGYRV ILVNSNPATIMTDEAFADEIYFEPLTAESLTAIIKKERPDGLLANLGGQTALNLAVEL EETGVLKEHGVKLLGTSVETIQKGEDREKFRSLMNELKQPVPESEIVDNEADALHFAE SIGFPVIIRPAYTLGGKGGGIAPDKEAFTAMIKQALLASPINQCLVEKSIAGFKEIEY EVMRDSNNTCITVCNMENIDPVGVHTGDSIVVAPSQTLTDEDYQMLRTASLTIISALD VVGGCNIQFALDPFSKQYYVIEVNPRVSRSSALASKATGYPIAKMAAKLAVGYTLDEL KNPLTGSTYASFEPALDYVIVKFPRWPFDKFKNADRKLGTKMKATGEVMAIERNLEAA IQKAAASLELKNIGTHLPELSGLSIDTLWDLAITPDDRRFFVVMELLSRSVSIDDIHE KTKIDPFFLHTFDNIIKLENRLMEAGSDLSFELLKKAKEKGFSDATIASLISKTEEEV RALRKEMGITPSFKIVDTCAAEFDAKTNYFYSTYFGETDGDISRKEKKRALIIGSGPI RIGQGVEFDYSAVHGVLTLQELGFETIMINNNPETVSTDYEIADRLYFEPMTTEHIVN VAEQENIDFAIVQFGGQTAINAAEALEKAGITLLGTSFQTLDVLEDRDQFYQLLDELG LKHAKGEIAYTKEEAASKASEIGYPVLIRPSYVIGGMGMIIVDSQAQLSQLLNDEDSM PYPILIDQYVSGKEVEIDLISDGEEVFIPTYTEHIERAGVHSGDSFAILPGPSITSGL QQGMKDAAQKIARKLSFKGIMNIQFVIDNGNILVLEVNPRASRTVPVVSKVMGVPMIP LATRLLAGASLKDLNPAVQNHHGVAVKFPVFSSHAIQDVDVKLGPEMKSTGEGMCVAY DSNSALKKIYTRVWSQKGSIYLQNVPEDVKELAENAGFTIHEGTFASWMEQEGNSLHI NLSGSEEARKERLEAMTHGIPVFTEEETVRAFLQSGSGHPQPVSLKDLYKKEVASCTQ *" /label="carB CDS" gene 1118819..1121911 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /label="carB gene" CDS 1121899..1122858 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /EC_number="2.1.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3099126, 6409881, 8025667, 9346304, 16585758, 26443366" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3099126, 6409881, 8025667, 9346304, 16585758, 26443366; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ornithine carbamoyltransferase" /protein_id="NP_389007.1" /db_xref="EnsemblGenomes-Gn:BSU11250" /db_xref="EnsemblGenomes-Tr:CAB12966" /db_xref="GOA:P18186" /db_xref="InterPro:IPR002292" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR024904" /db_xref="InterPro:IPR036901" /db_xref="SubtiList:BG10197" /db_xref="UniProtKB/Swiss-Prot:P18186" /translation="MHTVTQTSLYGKDLLTLKDLSEEDINALLAEAGELKQNKIQPIF HGKTLAMIFEKSSTRTRVSFEAGMAQLGGSALFLSQKDLQLGRGETVADTAKVLSGYV DAIMIRTFEHEKVEELAKEADIPVINGLTDKYHPCQALADLLTIKEIKGKLKGVKVAY IGDGNNVAHSLMIGCAKMGCDISIASPKGYEVLDEAAEAAKTYALQSGSSVTLTDDPI EAVKDADVIYSDVFTSMGQEAEEQERLAVFAPYQVNAALVSHAKPDYTFLHCLPAHRE EEVTAEIIDGPNSAVFQQAENRLHVQKALLKAILYKGESSKNC*" /label="argF CDS" gene 1121899..1122858 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /label="argF gene" downshifts 1122821 /Source="Nicolas_upshifts" /id="D609" /incds=0 /nref=141 /ntot=268 /MaxReadThrough="4.29547" /MaxDrop="7.69347" /score="22.2660758" /energy="-11.1" /TU="U899" /idTUdmin="U899" /TUdmin="-305" /isTUend="FALSE" /label="downshifts" S_feature complement(1122861..1123135) /Source="Nicolas_S_feature" /locus_tag="new_1204423_1204697_c" /HighExp="G135, G180, Cold, LBGexp, G150, B60, LoTm, Paraq, Oxctl, H2O2" /AntisenseName="yjzC" /AntisenseCor="-0.37122740772860502" /AntisenseRegPval="-9.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S399" promotor_-35 1122886..1122892 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1122894) /Source="Nicolas_upshifts" /id="D610" /incds=0 /nref=33 /ntot=166 /MaxReadThrough="1.19008" /MaxDrop="5.22155" /score="16.2777759" /energy="-11.2" /TU="NA" /idTUdmin="U902" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 1122907..1122918 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1122928 /Source="Nicolas_upshifts" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="upshifts" CDS 1122944..1123123 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25859258" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389008.1" /db_xref="EnsemblGenomes-Gn:BSU11260" /db_xref="EnsemblGenomes-Tr:CAB12967" /db_xref="InterPro:IPR025549" /db_xref="SubtiList:BG13223" /db_xref="UniProtKB/Swiss-Prot:O34585" /translation="MGQQHQFRPGQKAPNNGVYVEIGETGSMVKNPQKVHLSAGEMFP ETSNHNRLWTYKRKP*" /label="yjzC CDS" gene 1122944..1123123 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /label="yjzC gene" downshifts 1123133 /Source="Nicolas_upshifts" /id="D611" /incds=0 /nref=19 /ntot=53 /MaxReadThrough="0.25116" /MaxDrop="5.67653" /score="4.8153862" /energy="-10.9" /TU="NA" /idTUdmin="U899" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1123169..1123354) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19775244" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19775244; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore targeted protein" /protein_id="NP_389009.1" /db_xref="EnsemblGenomes-Gn:BSU11270" /db_xref="EnsemblGenomes-Tr:CAB12968" /db_xref="GOA:O34713" /db_xref="InterPro:IPR021324" /db_xref="SubtiList:BG13224" /db_xref="UniProtKB/Swiss-Prot:O34713" /translation="MRYIIAFIWTFLLSHMACYLVASMNSVTYNFKTSSVIAVVLYVL IMVLAEIMPMNKNASQH*" /label="yjzD CDS" gene complement(1123169..1123354) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /label="yjzD gene" downshifts complement(1123180) /Source="Nicolas_upshifts" /id="D612" /incds=0 /nref=215 /ntot=261 /MaxReadThrough="3.91391" /MaxDrop="6.26103" /score="9.62656276" /energy="-10.9" /TU="U902" /idTUdmin="U902" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1123383..1123402) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1123400) /Source="Nicolas_upshifts" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1123413..1123420) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1123455..1123461 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1123473..1123492 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1123478 /Source="Nicolas_upshifts" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1123535..1123544 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1123544 /Source="Nicolas_upshifts" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1123557..1123576 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1123603..1124337 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 18582593" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389010.1" /db_xref="EnsemblGenomes-Gn:BSU11280" /db_xref="EnsemblGenomes-Tr:CAB12969" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13124" /db_xref="UniProtKB/Swiss-Prot:O35001" /translation="MGITERYFQLGTEHNVIHLPYRPNGFGIFILGDRTHFVGHDSSF WQQHYGRNQLLSMLMNEGYTLFNSNLFGRHWGAEKAVTYAKQLIHSVLKQEILNPKIH ILAEGMGALVADELLRFSPDHIRSAAMLNPCLDLQAHYESEKENKFFYKQFLKEVSKS YGISEKEAEAIRYKTIQSYPSGVPVHIWQRMTGAPYPYSVHAEVFKEKQQKQGSPVDM TFHLFEHPSRIYASICKFFHSHEKEL*" /label="yjaU CDS" gene 1123603..1124337 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /label="yjaU gene" S_feature complement(1124096..1124698) /Source="Nicolas_S_feature" /locus_tag="new_1205658_1206260_c" /HighExp="S8, S6, S7, C30, BT, S4, S5, Pyr, S3, C90" /AntisenseName="yjaV" /AntisenseCor="0.66207512383157796" /AntisenseRegPval="-34.6" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.468" /TUlongSig="NA" /TUlongPSig="NA" /label="S400" promotor_-35 1124318..1124323 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1124336 /Source="Nicolas_upshifts" /id="D613" /incds=0 /nref=6 /ntot=47 /MaxReadThrough="5.56163" /MaxDrop="4.5381" /score="1.90624641" /energy="-10" /TU="U904,U905" /idTUdmin="U904" /TUdmin="-945" /isTUend="FALSE" /label="downshifts" upshifts 1124336 /Source="Nicolas_upshifts" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1124339..1124357 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1124419..1124976 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P) binding enzyme" /protein_id="NP_389011.2" /db_xref="EnsemblGenomes-Gn:BSU11290" /db_xref="EnsemblGenomes-Tr:CAB12970" /db_xref="SubtiList:BG13125" /db_xref="UniProtKB/Swiss-Prot:O34959" /translation="MESTLIVGADEFFGLSLCERMMDEGIHVDVVLAETEDKMRQMYL EERLMWLGRNELFRQLEHIGDQNYDTICIQFGSFLPLDQYDSPYILVYEEDRKEWDKR EKTGSEKTVILPKMYGPWKEETEEDGYYTNDVADELLRFLLEPSRHSKDQLFELQVTE KTSKEEAKTKIIEWKRQFSSIFDKY*" /label="yjaV CDS" gene 1124419..1124976 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /label="yjaV gene" promotor_-10 complement(1124678..1124697) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1124698) /Source="Nicolas_upshifts" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1124712..1124716) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1124983..1124990 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1125005..1125024 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1125017 /Source="Nicolas_upshifts" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="upshifts" CDS 1125067..1126020 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1203607, 21622736, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1203607, 21622736, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="positive regulator of comK" /protein_id="NP_389012.2" /db_xref="EnsemblGenomes-Gn:BSU11300" /db_xref="EnsemblGenomes-Tr:CAB12971" /db_xref="GOA:O32436" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13126" /db_xref="UniProtKB/Swiss-Prot:O32436" /translation="MITRLVMIFSVLLLLSGCGQTPFKGKIEKVGMLFPDTINDLVWG TKGYKGLLNIQSKYNVDVYYKEGVKTEEDIINAIEDFHKRGVNLLYGHGSEYAEVFNL VGEDYPDMEFVISNAKAKADNVTSVHFSGEAMGFFGGMTAAHMSKTNQVGVIASFTWQ PEVDGFIKGAKYENPDIEVNTKYTDHWDDDTTAVKLYQKMKNEGADVVYPAGDGYNVP VIQQIKKDGLYAIGYVTDQSDLGENTVLTSTVQNVDKAYEIIAEQFNKGTLEGGDHYY DLNTGVVEMGTFSPLVDQDFQQRIAKLIKTYNKTGELPKNE*" /label="med CDS" gene 1125067..1126020 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /label="med gene" promotor_-35 1125684..1125688 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1125704..1125723 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1125717 /Source="Nicolas_upshifts" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="upshifts" CDS 1126035..1126226 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10940045; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative late competence gene" /protein_id="NP_389013.1" /db_xref="EnsemblGenomes-Gn:BSU11310" /db_xref="EnsemblGenomes-Tr:CAB12972" /db_xref="GOA:O32437" /db_xref="InterPro:IPR024558" /db_xref="SubtiList:BG13221" /db_xref="UniProtKB/Swiss-Prot:O32437" /translation="MQHEKSLEFLQIAMKYLPEAKEQLEKSGIELSMEAIQPFMNLFT TVMAEAYELGKSDAKSETE*" /label="comZ CDS" gene 1126035..1126226 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /label="comZ gene" downshifts 1126205 /Source="Nicolas_upshifts" /id="D614" /incds=0 /nref=32 /ntot=192 /MaxReadThrough="4.56858" /MaxDrop="3.45953" /score="-7.49795364" /energy="-10.4" /TU="U907,U908" /idTUdmin="U905" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1126250..1126590 /Source="Nicolas_S_feature" /locus_tag="new_1207812_1208152" /HighExp="H2O2, C30, G135, Paraq, G180, G150, Oxctl, Cold, dia15, LPh" /AntisenseName="yjzB" /AntisenseCor="-0.34349942363230701" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S401" CDS complement(1126256..1126495) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /experiment="publication(s) with functional evidences, PMID:16391061, 22171814, 27227299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16391061, 22171814, 27227299; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389014.1" /db_xref="EnsemblGenomes-Gn:BSU11320" /db_xref="EnsemblGenomes-Tr:CAB12973" /db_xref="SubtiList:BG13222" /db_xref="UniProtKB/Swiss-Prot:O34891" /translation="MQLDVFSRMMFGDAAKPTEEKEEEQQEEVSQVSQTNDEETINYM HIMDQIGSIMNSLDQIKPALKELAPMLSAIKKKIM*" /label="yjzB CDS" gene complement(1126256..1126495) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /label="yjzB gene" downshifts complement(1126272) /Source="Nicolas_upshifts" /id="D615" /incds=0 /nref=21 /ntot=48 /MaxReadThrough="1.43519" /MaxDrop="5.47891" /score="-7.75082002" /energy="-10.4" /TU="NA" /idTUdmin="U909" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1126508..1126527) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1126529) /Source="Nicolas_upshifts" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1126541..1126550) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1126556..1126563 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1126578..1126597 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1126592 /Source="Nicolas_upshifts" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="upshifts" CDS 1126660..1127598 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 11959561, 21542858, 25196128" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 11959561, 21542858, 25196128; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 1" /protein_id="NP_389015.1" /db_xref="EnsemblGenomes-Gn:BSU11330" /db_xref="EnsemblGenomes-Tr:CAB12974" /db_xref="GOA:O34746" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13127" /db_xref="UniProtKB/Swiss-Prot:O34746" /translation="MKAGILGVGRYIPEKVLTNHDLEKMVETSDEWIRTRTGIEERRI AADDVFSSHMAVAAAKNALEQAEVAAEDLDMILVATVTPDQSFPTVSCMIQEQLGAKK ACAMDISAACAGFMYGVVTGKQFIESGTYKHVLVVGVEKLSSITDWEDRNTAVLFGDG AGAAVVGPVSDDRGILSFELGADGTGGQHLYLNEKRHTIMNGREVFKFAVRQMGESCV NVIEKAGLSKEDVDFLIPHQANIRIMEAARERLELPVEKMSKTVHKYGNTSAASIPIS LVEELEAGKIKDGDVVVMVGFGGGLTWGAIAIRWGR*" /label="fabHA CDS" gene 1126660..1127598 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /label="fabHA gene" promotor_-35 1126737..1126746 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1126755 /Source="Nicolas_upshifts" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1126758..1126773 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1127621..1128862 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /EC_number="2.3.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11325930, 12682299, 16436705, 18384517, 21542858, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325930, 12682299, 16436705, 18384517, 21542858, 28196402; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase II (involved in pimelate synthesis)" /protein_id="NP_389016.1" /db_xref="EnsemblGenomes-Gn:BSU11340" /db_xref="EnsemblGenomes-Tr:CAB12975" /db_xref="GOA:O34340" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR017568" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020841" /db_xref="PDB:4LS5" /db_xref="PDB:4LS6" /db_xref="PDB:4LS7" /db_xref="PDB:4LS8" /db_xref="SubtiList:BG13128" /db_xref="UniProtKB/Swiss-Prot:O34340" /translation="MTKKRVVVTGLGALSPLGNDVDTSWNNAINGVSGIGPITRVDAE EYPAKVAAELKDFNVEDYMDKKEARKMDRFTQYAVVAAKMAVEDADLNITDEIAPRVG VWVGSGIGGLETLESQFEIFLTKGPRRVSPFFVPMMIPDMATGQISIALGAKGVNSCT VTACATGTNSIGDAFKVIQRGDADVMVTGGTEAPLTRMSFAGFSANKALSTNPDPKTA SRPFDKNRDGFVMGEGAGIIVLEELEHALARGAKIYGEIVGYGSTGDAYHITAPAQDG EGGARAMQEAIKDAGIAPEEIDYINAHGTSTYYNDKYETMAIKTVFGEHAHKLAVSST KSMTGHLLGAAGGIEAIFSILAIKEGVIPPTINIQTPDEECDLDYVPDEARRQELNYV LSNSLGFGGHNATLIFKKYQS*" /label="fabF CDS" gene 1127621..1128862 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /label="fabF gene" promotor_-10 complement(1127835..1127853) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1127843) /Source="Nicolas_upshifts" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1127869..1127874) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1128713 /Source="Nicolas_upshifts" /id="D616" /incds=1 /nref=1 /ntot=89 /MaxReadThrough="7.03006" /MaxDrop="2.1101" /score="54.6350161" /energy="-18.5" /TU="U910,U911" /idTUdmin="U911" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 1128846 /Source="Nicolas_upshifts" /id="D617" /incds=0 /nref=246 /ntot=274 /MaxReadThrough="0.58964" /MaxDrop="7.80446" /score="54.6350161" /energy="-18.5" /TU="NA" /idTUdmin="U911" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-35 1128887..1128896 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-35" promotor_-10 1128909..1128928 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-10" upshifts 1128911 /Source="Nicolas_upshifts" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="upshifts" promotor_-35 1128923..1128931 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1128938..1129723 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389017.1" /db_xref="EnsemblGenomes-Gn:BSU11350" /db_xref="EnsemblGenomes-Tr:CAB12992" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13129" /db_xref="UniProtKB/Swiss-Prot:O31596" /translation="MSVEQTYSWLRKAGSIDDLAHYIIPLFSGAEKKNWKGILGHLQH HGMFKNIKEGIQTVSKLKEKGFYGHIQKEEQYLKNKWQGPDVPIVTLPVDERNRRIRL EFGSKSGLAFQDKMFLFLSSDLDFGSVSALMTHEYHHVCRLGHLTKEEKDVTLLDTII MEGLAEYAVYERFGRSQTAEWTTWYTPEQLQALYEKKIAPHRDIKRDNRLFPQLLFGK GYQPKMLGYAVGFNIVKKYLTASKASTADGLSIPAETFLDAML*" /label="yjaZ CDS" gene 1128938..1129723 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /label="yjaZ gene" promotor_-10 1128943..1128961 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1128955 /Source="Nicolas_upshifts" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1129724..1129808 /Source="Nicolas_S_feature" /locus_tag="new_1211286_1211370" /HighExp="S6, S5, S8, S7, BT, S4, S3, B36, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S402" promotor_-10 complement(1129740..1129758) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1129757) /Source="Nicolas_upshifts" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1129773..1129778) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1129776..1129783 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1129798..1129817 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1129810..1129914 /Source="Nicolas_S_feature" /locus_tag="new_1211372_1211476" /HighExp="LoTm, T4.0H, T3.0H, T5.0H, T3.30H, T2.30H, M9-stat, S1, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S403" upshifts 1129810 /Source="Nicolas_upshifts" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1129915..1130901 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389018.1" /db_xref="EnsemblGenomes-Gn:BSU11360" /db_xref="EnsemblGenomes-Tr:CAB12993" /db_xref="GOA:P42064" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11085" /db_xref="UniProtKB/Swiss-Prot:P42064" /translation="MSTLLEVNNLKTYFFRKKEPIPAVDGVDFHISKGETVALVGESG SGKSITSLSIMGLVQSSGGKIMDGSIKLEDKDLTSFTENDYCKIRGNEVSMIFQEPMT SLNPVLTIGEQITEVLIYHKNMKKKEARQRAVELLQMVGFSRAEQIMKEYPHRLSGGM RQRVMIAIALSCNPKLLIADEPTTALDVTIQAQVLELMKDLCQKFNTSILLITHDLGV VSEAADRVIVMYCGQVVENATVDDLFLEPLHPYTEGLLTSIPVIDGEIDKLNAIKGSV PTPDNLPPGCRFAPRCPKAMDKCWTNQPSLLTHKSGRTVRCFLYEEEGAEQS*" /label="appD CDS" gene 1129915..1130901 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /label="appD gene" CDS 1130898..1131887 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389019.2" /db_xref="EnsemblGenomes-Gn:BSU11370" /db_xref="EnsemblGenomes-Tr:CAB12994" /db_xref="GOA:P42065" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11086" /db_xref="UniProtKB/Swiss-Prot:P42065" /translation="MTAANQETILELRDVKKYFPIRSGLFQRKVGDVKAVDGVSFSLK KGETLGIVGESGCGKSTAGRTMIRLYKPTEGQILFKGQDISNLSEEKLRKSVRKNIQM VFQDPFASLNPRKTLRSIIKEPFNTHNMYTMRERNEKVEELLARVGLHPSFAGRYPHE FSGGQRQRIGIARALTLNPELIIADEPVSALDVSIQAQVINLMEELQEEFNLTYLFIS HDLSVVRHISDRVGVMYLGKMMELTGKHELYDNPLHPYTQALLSSVPVTRKRGSVKRE RIVLKGELPSPANPPKGCVFHTRCPVAKPICKEQIPEFKEAAPSHFVACHLYS*" /label="appF CDS" gene 1130898..1131887 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /label="appF gene" misc_feature 1131893..1131899 /Source="Nicolas_upshift_promotors" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1131898..1131974 /Source="Nicolas_S_feature" /locus_tag="new_1213460_1213536" /HighExp="T2.0H, S1, M9-stat, T5.0H, T3.0H, T1.30H, S2, M0t90, T2.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="SigK" /TUlongPSig=1 /label="S404" upshifts 1131898 /Source="Nicolas_upshifts" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1131975..1132466 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15588833, 25355936; Product type rc: receptor" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); N-terminal part of AppA" /translation="MKRRKTALMMLSVLMVLAIFLSACSGSKSSNSSAKKSAGKPQQG GDLVVGSIGEPTLFNSLYSTDDASTDIENMLYSFLTKTDEKLNVKLSLAESIKELDGG LAYDVKIKKGVKFHDGKELTADDVVFTYSVPLSKDYKGERGSTYEMLKSVEKKAITKS CLS*" /label="appAn CDS" gene 1131975..1132466 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /pseudo /label="appAn gene" CDS 1132439..1133605 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7997159, 15588833, 26728191; Product type lp: lipoprotein" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); C-terminal part of AppA" /translation="GDYEVLFKLKYKDGNFYNNALDSTAILPKHILGNVPIADLEENE FNRKKPIGSGPFKFKEWKQGQYIKLEANDDYFEGRPYLDTVTYKVIPDANAAVAQLQA GDINFFNVPATDYKTAEKFNNLKIVTDLALSYVYIGWNEKNELFKDKKVRQALTTALD RESIVSQVLDGDGEVAYIPESPLSWNYPKDIDVPKFEYNEKKAKQMLAEAGWKDTNGD GILDKDGKKFSFTLKTNQGNKVREDIAVVVQEQLKKIGIEVKTQIVEWSALVEQMNPP NWDFDAMVMGWSLSTFPDQYDIFHSSQIKKGLNYVWYKNAEADKLMKDAKSISDRKQY SKEYEQIYQKIAEDQPYTFLYYPNNHMAMPENLEGYKYHPKRDLYNIEKWWLAK*" /label="appAc CDS" gene 1132439..1133605 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /pseudo /label="appAc gene" downshifts 1133596 /Source="Nicolas_upshifts" /id="D618" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="7.71397" /MaxDrop="3.11667" /score="-1.00317393" /energy="-13.3" /TU="U916,U917" /idTUdmin="U913" /TUdmin=1715 /isTUend="FALSE" /label="downshifts" CDS 1133681..1134631 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389021.2" /db_xref="EnsemblGenomes-Gn:BSU11390" /db_xref="EnsemblGenomes-Tr:CAB12996" /db_xref="GOA:P42062" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11088" /db_xref="UniProtKB/Swiss-Prot:P42062" /translation="MAAYIIRRTLMSIPILLGITILSFVIMKAAPGDPMTLMMDPKIS QADREQFIEKYGLNDPQYVQYLKWLGNMVQGDFGTSIVRKGTPVSELIMARLPNTLLL MLVSTILALMISIPFGVLSAKRPYSKIDYGITFTSFIGLAIPNFWFGLILIMVLSVNL GWFPTGGVETLNTEFNIFDRIHHLILPAFVLATADMAGLTRYTRSNMLDVLNQDYIRT ARAKGFKENRVLFKHGLRNALLPVITIFGLMIPSFIGGSVVVEQIFTWPGLGKLFVDS AFQRDYPVIMAMTVISAVLVVVGNLIADILYAIVDPRIEY*" /label="appB CDS" gene 1133681..1134631 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /label="appB gene" CDS 1134648..1135559 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389022.1" /db_xref="EnsemblGenomes-Gn:BSU11400" /db_xref="EnsemblGenomes-Tr:CAB12997" /db_xref="GOA:P42063" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11089" /db_xref="UniProtKB/Swiss-Prot:P42063" /translation="MSELQTTPSPEIRLKENISKKPETMTKIFWEKFSKNKLAILGAV ILFIIIMSAVFAPLIAPYPQEQQSLLDKYKAPGLEHLMGTDKFGRDIFSRILYGARVS LLVGFASVVGSILIGTVLGALAGYFRGIVDAVIMRVVDIVLSIPDIFLLITLVTIFKP GVDKLILIFCLTGWTTTARLVRGEFLSLRSREYVLAAKTIGTKTHKIIFSHILPNALG PIIVSATLKVGSVILAESALSYLGFGIQPPIASWGNMLQDAQNFTVMIQAWWYPLFPG LFILMTVLCFNFVGDGLRDALDPKNIK*" /label="appC CDS" gene 1134648..1135559 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /label="appC gene" downshifts 1135573 /Source="Nicolas_upshifts" /id="D619" /incds=0 /nref=62 /ntot=188 /MaxReadThrough="5.13927" /MaxDrop="5.50153" /score="22.0028545" /energy="-11.6" /TU="U916,U917" /idTUdmin="U916" /TUdmin="-923" /isTUend="FALSE" /label="downshifts" S_feature 1135618..1135725 /Source="Nicolas_S_feature" /locus_tag="new_1217180_1217287" /HighExp="LoTm, S1, S2, BT, T3.30H, T4.0H, T5.0H, T3.0H, Glu, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S405" promotor_-35 1135698..1135703 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1135719..1135737 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1135727 /Source="Nicolas_upshifts" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1135764..1136516 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717292, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation nucleic acid binding protein" /protein_id="NP_389023.1" /db_xref="EnsemblGenomes-Gn:BSU11410" /db_xref="EnsemblGenomes-Tr:CAB12998" /db_xref="InterPro:IPR020909" /db_xref="SubtiList:BG13130" /db_xref="UniProtKB/Swiss-Prot:O31597" /translation="MLFLHDVWVNWFEGEENGYNVCHFHEWRKEDTVELLDQVPLLRV PSVLFHYIENDLSELPKGLLEDVHQKSYIRKNHERTKLEYCFVVTDGIGILAVDTIGY TIPVRKSRLIPRQEQLVYEMVKDVEPETYEFEPKKLESSKEYHILSLAPEHVRGLTRK ERQIKQLMFMALDQLKGLKNRAEIGYWYTEWNPHMYEQIKRMSFEEIWDMLYNETIEG WSDKHLAFCENLIKGQPFFEKLWEMENESKVN*" /label="yjbA CDS" gene 1135764..1136516 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /label="yjbA gene" downshifts 1136496 /Source="Nicolas_upshifts" /id="D620" /incds=0 /nref=32 /ntot=112 /MaxReadThrough="1.07428" /MaxDrop="6.2264" /score="22.0028545" /energy="-11.6" /TU="NA" /idTUdmin="U916" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1136551..1137543) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /EC_number="6.1.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8950174, 10706627, 12682299, 24572018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8950174, 10706627, 12682299, 24572018; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophanyl-tRNA synthetase" /protein_id="NP_389024.1" /db_xref="EnsemblGenomes-Gn:BSU11420" /db_xref="EnsemblGenomes-Tr:CAB12999" /db_xref="GOA:P21656" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002306" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024109" /db_xref="PDB:3PRH" /db_xref="SubtiList:BG10799" /db_xref="UniProtKB/Swiss-Prot:P21656" /translation="MKQTIFSGIQPSGSVTLGNYIGAMKQFVELQHDYNSYFCIVDQH AITVPQDRLELRKNIRNLAALYLAVGLDPEKATLFIQSEVPAHAQAGWMMQCVAYIGE LERMTQFKDKSKGNEAVVSGLLTYPPLMAADILLYGTDLVPVGEDQKQHLELTRNLAE RFNKKYNDIFTIPEVKIPKVGARIMSLNDPLKKMSKSDPNQKAYITLLDEPKQLEKKI KSAVTDSEGIVKFDKENKPGVSNLLTIYSILGNTTIEELEAKYEGKGYGEFKGDLAEV VVNALKPIQDRYYELIESEELDRILDEGAERANRTANKMLKKMENAMGLGRKRR*" /label="trpS CDS" gene complement(1136551..1137543) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /label="trpS gene" downshifts complement(1136572) /Source="Nicolas_upshifts" /id="D621" /incds=0 /nref=224 /ntot=255 /MaxReadThrough="1.77115" /MaxDrop="6.72647" /score="27.6275522" /energy="-11.6" /TU="U919" /idTUdmin="U919" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" misc_RNA complement(1137602..1137816) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /product="T-box riboswitch specific of tryptophan tRNA" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" /label="tboWA RNA" gene complement(1137602..1137816) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /label="tboWA gene" downshifts complement(1137650) /Source="Nicolas_upshifts" /id="D622" /incds=0 /nref=37 /ntot=127 /MaxReadThrough="6.8472" /MaxDrop="5.13001" /score="25.1445248" /energy="-19" /TU="U919" /idTUdmin="U919" /TUdmin="-1100" /isTUend="FALSE" /label="downshifts" misc_feature complement(1137835..1137854) /Source="Nicolas_upshift_promotors" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1137848) /Source="Nicolas_upshifts" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1138103..1138110 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1138124..1138286 /Source="Nicolas_S_feature" /locus_tag="new_1219686_1219848" /HighExp="S1, T3.0H, T3.30H, T2.30H, T4.0H, T5.0H, LoTm, T2.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S406" promotor_-10 1138125..1138144 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1138125 /Source="Nicolas_upshifts" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="upshifts" CDS 1138287..1139924 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (binding lipoprotein)" /protein_id="NP_389025.1" /db_xref="EnsemblGenomes-Gn:BSU11430" /db_xref="EnsemblGenomes-Tr:CAB13000" /db_xref="GOA:P24141" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10771" /db_xref="UniProtKB/Swiss-Prot:P24141" /translation="MKKRWSIVTLMLIFTLVLSACGFGGSGSNGEGKKDSKGKTTLNI NIKTEPFSLHPGLANDSVSGGVIRQTFEGLTRINADGEPEEGMASKIETSKDGKTYTF TIRDGVKWSNGDPVTAQDFEYAWKWALDPNNESQYAYQLYYIKGAEAANTGKGSLDDV AVKAVNDKTLKVELNNPTPYFTELTAFYTYMPINKKIAEKNKKWNTNAGDDYVSNGPF KMTAWKHSGSITLEKNDQYWDKDKVKLKKIDMVMINNNNTELKKFQAGELDWAGMPLG QLPTESLPTLKKDGSLHVEPIAGVYWYKFNTEAKPLDNVNIRKALTYSLDRQSIVKNV TQGEQIPAMAAVPPTMKGFEDNKEGYFKDNDVKTAKEYLEKGLKEMGLSKASDLPKIK LSYNTDDAHAKIAQAVQEMWKKNLGVDVELDNSEWNVYIDKLHSQDYQIGRMGWLGDF NDPINFLELFRDKNGGNNDTGWENPEFKKLLNQSQTETDKTKRAELLKKAEGIFIDEM PVAPIYFYTDTWVQDENLKGVIMPGTGEVYFRNAYFK*" /label="oppA CDS" gene 1138287..1139924 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /label="oppA gene" downshifts 1139818 /Source="Nicolas_upshifts" /id="D623" /incds=1 /nref=8 /ntot=166 /MaxReadThrough="6.94127" /MaxDrop="3.3677" /score="-4.2761508" /energy="-15.6" /TU="U920" /idTUdmin="U916" /TUdmin=3322 /isTUend="FALSE" /label="downshifts" S_feature 1139925..1140031 /Source="Nicolas_S_feature" /locus_tag="new_1221487_1221593" /HighExp="S1, LoTm, T4.0H, BT, T3.30H, T3.0H, T5.0H, M0t90, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S407" CDS 1140032..1140967 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 17600541, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 17600541, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389026.1" /db_xref="EnsemblGenomes-Gn:BSU11440" /db_xref="EnsemblGenomes-Tr:CAB13001" /db_xref="GOA:P24138" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10772" /db_xref="UniProtKB/Swiss-Prot:P24138" /translation="MLKYIGRRLVYMIITLFVIVTVTFFLMQAAPGGPFSGEKKLPPE IEANLNAHYGLDKPLFVQYVSYLKSVAMWDFGPSFKYKGQSVNDLISSGFPVSFTLGA EAILLALALGVLFGVIAALYHNKWQDYTVAILTIFGISVPSFIMAAVLQYVFSMKLGL FPVAGWDSWAYTFLPSIALASMPMAFIARLSRSSMIEVLNSDYIRTAKAKGLSRPAVT VRHAIRNALLPVVTYMGPMAAQVLTGSFIIETIFGIPGLGAHFVNSITNRDYTVIMGV TVFFSVILLLCVLIVDVLYGIIDPRIKLSKAKKGA*" /label="oppB CDS" gene 1140032..1140967 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /label="oppB gene" promotor_-10 complement(1140075..1140094) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1140092) /Source="Nicolas_upshifts" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1140110..1140116) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1140971..1141888 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 26782429" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 26782429; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389027.1" /db_xref="EnsemblGenomes-Gn:BSU11450" /db_xref="EnsemblGenomes-Tr:CAB13002" /db_xref="GOA:P24139" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10773" /db_xref="UniProtKB/Swiss-Prot:P24139" /translation="MQNIPKNMFEPAAANAGDAEKISKKSLSLWKDAMLRFRSNKLAM VGLIIIVLIILMAIFAPMFSRYDYSTTNLLNADKPPSKDHWFGTDDLGRDIFVRTWVG ARISIFIGVAAAVLDLLIGVIWGSISGFRGGRTDEIMMRIADILWAVPSLLMVILLMV VLPKGLFTIIIAMTITGWINMARIVRGQVLQLKNQEYVLASQTLGAKTSRLLFKHIVP NAMGSILVTMTLTVPTAIFTEAFLSYLGLGVPAPLASWGTMASDGLPALTYYPWRLFF PAGFICITMFGFNVVGDGLRDALDPKLRK*" /label="oppC CDS" gene 1140971..1141888 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /label="oppC gene" CDS 1141893..1142969 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 19202088, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 19202088, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389028.1" /db_xref="EnsemblGenomes-Gn:BSU11460" /db_xref="EnsemblGenomes-Tr:CAB13003" /db_xref="GOA:P24136" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10774" /db_xref="UniProtKB/Swiss-Prot:P24136" /translation="MIRVTRLLEVKDLAISFKTYGGEVQAIRGVNFHLDKGETLAIVG ESGSGKSVTSQAIMKLIPMPPGYFKRGEILFEGKDLVPLSEKEMQNVRGKEIGMIFQD PMTSLNPTMKVGKQITEVLFKHEKISKEAAKKRAVELLELVGIPMPEKRVNQFPHEFS GGMRQRVVIAMALAANPKLLIADEPTTALDVTIQAQILELMKDLQKKIDTSIIFITHD LGVVANVADRVAVMYAGQIVETGTVDEIFYDPRHPYTWGLLASMPTLESSGEEELTAI PGTPPDLTNPPKGDAFALRSSYAMKIDFEQEPPMFKVSDTHYVKSWLLHPDAPKVEPP EAVKAKMRKLANTFEKPVLVREVE*" /label="oppD CDS" gene 1141893..1142969 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /label="oppD gene" CDS 1142971..1143888 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 7997159, 11401703, 23133654, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 7997159, 11401703, 23133654, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389029.1" /db_xref="EnsemblGenomes-Gn:BSU11470" /db_xref="EnsemblGenomes-Tr:CAB13004" /db_xref="GOA:P24137" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10775" /db_xref="UniProtKB/Swiss-Prot:P24137" /translation="MTEKLLEIKHLKQHFVTPRGTVKAVDDLSFDIYKGETLGLVGES GCGKSTTGRSIIRLYEATDGEVLFNGENVHGRKSRKKLLEFNRKMQMIFQDPYASLNP RMTVADIIAEGLDIHKLAKTKKERMQRVHELLETVGLNKEHANRYPHEFSGGQRQRIG IARALAVDPEFIIADEPISALDVSIQAQVVNLMKELQKEKGLTYLFIAHDLSMVKYIS DRIGVMYFGKLVELAPADELYENPLHPYTKSLLSAIPLPDPDYERNRVRQKYDPSVHQ LKDGETMEFREVKPGHFVMCTEAEFKAFS*" /label="oppF CDS" gene 1142971..1143888 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /label="oppF gene" downshifts 1143858 /Source="Nicolas_upshifts" /id="D624" /incds=0 /nref=21 /ntot=196 /MaxReadThrough="1.58906" /MaxDrop="5.17491" /score="28.2861081" /energy="-15.2" /TU="NA" /idTUdmin="U920" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 1143938..1143941 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1143954 /Source="Nicolas_upshifts" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1143956..1143975 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1143995..1145212 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563878, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_389030.2" /db_xref="EnsemblGenomes-Gn:BSU11480" /db_xref="EnsemblGenomes-Tr:CAB13005" /db_xref="GOA:O31600" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13131" /db_xref="UniProtKB/Swiss-Prot:O31600" /translation="MQFLHNKNVFALLLSQSFQSLAGVLVTIVLMVRIYQMTDSVFLA GLILSFMSFASIAASFCVSPVLRILGFKKVLAGANLLRAVFIILMAYSVTHHGQAFFW ITLLFVFCFSFAGAFFQPARFALLPIIVPKKQYVKANGVISLSNQLFLTAGWGLGGLL TYAVPFELVVGAAICLFVLSGASISVLHVNEEEAAGTAETASVRSIWKDLMIIPIVRD ITVMDMLEALAGSVWSSAILLAFTAAVLHETEVWWGMFNASYFIGAIVGSVIAIRFSS FFERNMGYAIMFSSLVMSALTLLFSFSPVPFLCALACAAMGPFYQVRDICQETMLQEV IPEQKRIGIMAAKNAILTPWSGVTYSIMGLVADAAGAKIAFIAAAALYIMTFLIALAQ PRLVHYRRENRVQ*" /label="yjbB CDS" gene 1143995..1145212 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /label="yjbB gene" promotor_-35 1145265..1145274 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-35" promotor_-10 1145287..1145302 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-10" S_feature 1145296..1145375 /Source="Nicolas_S_feature" /locus_tag="new_1226858_1226937" /HighExp="Etha, B60, M9-stat, T0.30H, Salt, T3.0H, T1.0H, T4.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S408" upshifts 1145296 /Source="Nicolas_upshifts" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="upshifts" CDS 1145376..1145954 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17158660, 17158663, 21815947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol oxidation management factor; putative acetyltransferase" /protein_id="NP_389031.2" /db_xref="EnsemblGenomes-Gn:BSU11490" /db_xref="EnsemblGenomes-Tr:CAB13006" /db_xref="GOA:O31601" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13132" /db_xref="UniProtKB/Swiss-Prot:O31601" /translation="MNWYEKLSEYFPIEEMKSKAHMEALLKERSDIYHKDEGKHHILM FAEFDSFIFVDYLYVSKDARGQGLGGKLIAKLKKKNKPILLEVEPVDEDDTDTEKRLR FYQREHFKHAQSIGYRRRSLATNEVNKMEILYWSPKTESEEEILEAMKQTYENIHTYK DEKWYGESYEKTDEVLEIIDEEKQKNIFDQLS*" /label="yjbC CDS" gene 1145376..1145954 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /label="yjbC gene" S_feature 1145955..1146069 /Source="Nicolas_S_feature" /locus_tag="new_1227517_1227631" /HighExp="B60, Etha, Salt, T0.30H, M9-stat, LoTm, Gly, T1.0H, B36, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S409" promotor_-10 complement(1146006..1146025) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1146010) /Source="Nicolas_upshifts" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1146039..1146046) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1146072..1146085 /Source="Nicolas_upshift_promotors" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1146072 /Source="Nicolas_upshifts" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="upshifts" CDS 1146135..1146530 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="redox-sensitive regulator" /protein_id="NP_389032.1" /db_xref="EnsemblGenomes-Gn:BSU11500" /db_xref="EnsemblGenomes-Tr:CAB13007" /db_xref="GOA:O31602" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR023731" /db_xref="InterPro:IPR036249" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG13133" /db_xref="UniProtKB/Swiss-Prot:O31602" /translation="MVTLYTSPSCTSCRKARAWLEEHEIPFVERNIFSEPLSIDEIKQ ILRMTEDGTDEIISTRSKVFQKLNVNVESMPLQDLYRLINEHPGLLRRPIIIDEKRLQ VGYNEDEIRRFLPRKVRSFQLREAQRLAN*" /label="spxA CDS" gene 1146135..1146530 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /label="spxA gene" promotor_no_box complement(1146366..1146466) /Source="Nicolas_upshift_promotors" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1146406) /Source="Nicolas_upshifts" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1146528 /Source="Nicolas_upshifts" /id="D625" /incds=0 /nref=263 /ntot=269 /MaxReadThrough="4.34531" /MaxDrop="8.0579" /score="7.42972561" /energy="-8.8" /TU="U923" /idTUdmin="U925" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1146573..1147362 /Source="Nicolas_S_feature" /locus_tag="new_1228135_1228924" /HighExp="B60, B36, Etha, M9-stat, Salt, H2O2, Paraq, Cold, G180, G135" /AntisenseName="yjbE" /AntisenseCor="-0.18634010398760401" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S410" CDS complement(1146573..1147229) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389033.1" /db_xref="EnsemblGenomes-Gn:BSU11510" /db_xref="EnsemblGenomes-Tr:CAB13008" /db_xref="GOA:O31603" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022301" /db_xref="SubtiList:BG13134" /db_xref="UniProtKB/Swiss-Prot:O31603" /translation="MEHDYLISLLVIVGIDLILGGDNAVVIAMASRHLPDKQRQQAII LGTFIAVAMRIGLTSAAVYLLNIPFLQCAGGIFLLYLGYQLLIEKKDTKHIKSSTSLW RAIRTIVLADLFMSLDNVIAVAGASHGEFSLVVIGLCVSVPVIIWGSKLIHIALEKIP LLIYAGSGLLAYTGGEMIVRDKKLSLFMAQHGTVETLLPILTVAFVILASIYYQQVEK *" /label="yjbE CDS" gene complement(1146573..1147229) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /label="yjbE gene" promotor_-10 complement(1147259..1147277) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1147274) /Source="Nicolas_upshifts" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1147292..1147297) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1147335..1147342 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1147356..1147375 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1147364..1147505 /Source="Nicolas_S_feature" /locus_tag="new_1228926_1229067" /HighExp="B60, Diami, Etha, dia5, LPhT, M9-stat, T5.0H, T3.0H, dia15, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S411" upshifts 1147364 /Source="Nicolas_upshifts" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="upshifts" CDS 1147399..1147539 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513949.1" /translation="MVKVKMWTEWVKCSKVQLIGSLDVPSTSYIEGKVGKWKLKELTS IQ*" /label="conserved hypothetical protein CDS" gene 1147399..1147539 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /label="gene" CDS 1147506..1148162 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10361283, 10447896, 16525504, 19801546, 21435029, 23595989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 10447896, 16525504, 19801546, 21435029, 23595989; Product type f : factor" /codon_start=1 /transl_table=11 /product="adaptor protein controlling oligomerization of the AAA+ protein ClpC" /protein_id="NP_389034.1" /db_xref="EnsemblGenomes-Gn:BSU11520" /db_xref="EnsemblGenomes-Tr:CAB13009" /db_xref="GOA:P37958" /db_xref="InterPro:IPR008681" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3JTP" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="SubtiList:BG10680" /db_xref="UniProtKB/Swiss-Prot:P37958" /translation="MEIERINEHTVKFYMSYGDIEDRGFDREEIWYNRERSEELFWEV MDEVHEEEEFAVEGPLWIQVQALDKGLEIIVTKAQLSKDGQKLELPIPEDKKQEPASE DLDALLDDFQKEEQAVNQEEKEQKLQFVLRFGDFEDVISLSKLNVNGSKTTLYSFENR YYLYVDFCNMTDEEVENQLSILLEYATESSISIHRLEEYGKLIISEHALETIKKHFAS *" /label="mecA CDS" gene 1147506..1148162 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /label="mecA gene" downshifts 1148152 /Source="Nicolas_upshifts" /id="D626" /incds=0 /nref=120 /ntot=308 /MaxReadThrough="5.41786" /MaxDrop="7.67172" /score="32.2431225" /energy="-11.8" /TU="U928" /idTUdmin="U928" /TUdmin="-774" /isTUend="FALSE" /label="downshifts" CDS complement(1148157..1148279) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513950.1" /translation="MINSCSLYFLLVYMFLIFHISKMAFSCIKKTDFRKEIGLL*" /label="conserved hypothetical protein CDS" gene complement(1148157..1148279) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /label="gene" S_feature 1148197..1148286 /Source="Nicolas_S_feature" /locus_tag="new_1229759_1229848" /HighExp="Etha, M9-stat, B60, dia15, T0.30H, Diami, C30, H2O2, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S412" promotor_-35 1148265..1148273 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1148284..1148302 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1148288..1148352 /Source="Nicolas_S_feature" /locus_tag="new_1229850_1229914" /HighExp="Etha, G/S, GM 150, T-4.40H, S2, T-2.40H, Pyr, C90, M9-tran, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.876, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S413" upshifts 1148288 /Source="Nicolas_upshifts" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="upshifts" CDS 1148353..1149474 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10438773, 17630974, 23046409, 26880300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438773, 17630974, 23046409, 26880300; Product type s: structure" /codon_start=1 /transl_table=11 /product="protein involved in establishment of DNA transport in competence" /protein_id="NP_389035.1" /db_xref="EnsemblGenomes-Gn:BSU11530" /db_xref="EnsemblGenomes-Tr:CAB13010" /db_xref="GOA:O31604" /db_xref="InterPro:IPR010330" /db_xref="InterPro:IPR021176" /db_xref="SubtiList:BG13135" /db_xref="UniProtKB/Swiss-Prot:O31604" /translation="MFHLLGAQQNQKLKRRRFFCPVCGGELAVKLGLQKAPHFAHKQN KSCAIDIEPESAYHLEGKRQLYVWLKTQRASPILEPYIRTINQRPDVMARIKEHMLAV EYQCATIAPDVFQKRTEGFKQEGIIPQWIMGYSRLKRTASSFYQLSTFHWQFINASPY RELICYCPERRSFLRLSHIIPFYTNHSYSSVQTIPIHRAGAGDLFFTEPKPSIQYSGW TKAIHRFRHKPHRFNSKETNRLRLLFYEKRQTPFSFLPTEVFVPVRKGAVFKSPVFVW QGFLYLFMTDLGGKRAPIRFSAVLQQCKLHIHNKNIALRSECSEECLSEAVKQYIDFL CKKGFLRETQKEVYVLNQPAGGIHSMQDLIERDRSCFIE*" /label="coiA CDS" gene 1148353..1149474 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /label="coiA gene" promotor_-35 1149128..1149134 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" upshifts 1149146 /Source="Nicolas_upshifts" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="upshifts" promotor_-10 1149149..1149167 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" promotor_-35 1149360..1149368 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" promotor_-10 1149380..1149398 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" upshifts 1149387 /Source="Nicolas_upshifts" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="upshifts" promotor_-35 1149468..1149474 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1149489..1149500 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1149498 /Source="Nicolas_upshifts" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="upshifts" CDS 1149521..1151533 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11741842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11741842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoendopeptidase F" /protein_id="NP_389036.2" /db_xref="EnsemblGenomes-Gn:BSU11540" /db_xref="EnsemblGenomes-Tr:CAB13011" /db_xref="GOA:O31605" /db_xref="InterPro:IPR001567" /db_xref="InterPro:IPR004438" /db_xref="InterPro:IPR013647" /db_xref="SubtiList:BG13136" /db_xref="UniProtKB/Swiss-Prot:O31605" /translation="MKGTKGKVFRVFTAFLAFVLFITAYDLTKGSEKPEDIHNTSLLR NSCFFNWLESKKTRGITMAEEKKANQLPDRSEVKAEDTWRLEDIFPSDEAWNKEFQAV KELIPNLSKYKGKLADSADHLYEALTYQDKVMERLGRLYTYAHMRSDQDTGNSFYQGL NDKAGNLYTQAASATAYLVPEILSIEEDKLQQFILEKEELKLYSHAIEEITKERPHVL SEKEEALLAEASEVLGSSSNTFSVLNNADITFPSIKDEDGNEKQITHGNFINFLESEN REVRKNAFDAVYKTYGQYKNTMATTLSGTVKKDNFYARVKKYKSAREAALSNNSIPEE VYDNLVKTINKHLPLLHRYIALRKKVLELDEVHIYDLYTPLVKDAGMKVTYEEAKDYM LKGLAPLGEEYASILKEGLENRWVDVYENKGKRNGAYSSGAYGTNPYILMNWHNNVNN LFTLVHEFGHSVHSYYTRKHQPYPYGNYSIFVAEVASTTNEALLGEYLLNNLEDEKQR LYILNHMLEGFRGTVFRQTMFAEFEHLIHTKAQEGEPLTPELLTNVYYDLNKKYFGDG MVIDKEIGLEWSRIPHFYYNYYVYQYATGYSAAQALSSQILKEGKPAVDRYIDFLKAG SSQYPIDVLKKAGVDMTSPEPIEAACKMFEEKLDEMEELLMKVKQS*" /label="pepF CDS" gene 1149521..1151533 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /label="pepF gene" promotor_-35 1149596..1149603 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-35" promotor_-10 1149618..1149637 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-10" upshifts 1149630 /Source="Nicolas_upshifts" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="upshifts" downshifts 1151480 /Source="Nicolas_upshifts" /id="D627" /incds=0 /nref=98 /ntot=339 /MaxReadThrough="4.70576" /MaxDrop="5.74441" /score="19.0969124" /energy="-15.2" /TU="U933" /idTUdmin="U931" /TUdmin=2 /isTUend="TRUE" /label="downshifts" S_feature 1151534..1151835 /Source="Nicolas_S_feature" /locus_tag="new_1233096_1233397" /HighExp="Etha, dia15, Diami, B60, M9-stat, S8, M0t90, dia5, B36, T0.30H" /AntisenseName="yizD" /AntisenseCor="-1.29003203536192E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="SigH, SigB" /TUlongPSig="0.999, 0.999" /label="S414" CDS complement(1151571..1151738) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097703.1" /db_xref="EnsemblGenomes-Gn:BSU11549" /db_xref="EnsemblGenomes-Tr:CAX52593" /db_xref="GOA:C0H3Y6" /db_xref="UniProtKB/Swiss-Prot:C0H3Y6" /translation="MMSTLISIVCIAVFFCLNILGMMHMLPLYITSPLLFLSILFTLY RLNHRKTFKGF*" /label="yizD CDS" gene complement(1151571..1151738) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /label="yizD gene" downshifts complement(1151584) /Source="Nicolas_upshifts" /id="D628" /incds=0 /nref=8 /ntot=61 /MaxReadThrough="1.527" /MaxDrop="5.54041" /score="-4.56163992" /energy="-15.2" /TU="NA" /idTUdmin="U934" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1151758..1151776) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1151774) /Source="Nicolas_upshifts" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1151792..1151797) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1151828..1151835 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1151837..1151962 /Source="Nicolas_S_feature" /locus_tag="new_1233399_1233524" /HighExp="B36, T-1.10H, nit, T-0.40H, M9-tran, LoTm, Pyr, Etha, Salt, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.883" /TUlongSig="SigA, SigH, SigB" /TUlongPSig="0.926, 0.999, 0.999" /label="S415" upshifts 1151837 /Source="Nicolas_upshifts" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1151843..1151981 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /product="small regulatory RNA (NO regulated)" /experiment="publication(s) with functional evidences, PMID:19682248, 19786493, 20511587, 20525796, 25643072, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682248, 19786493, 20511587, 20525796, 25643072, 28436820; Product type n : RNA" /label="roxS RNA" gene 1151843..1151981 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /label="roxS gene" promotor_-10 1151850..1151869 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1151919 /Source="Nicolas_upshifts" /id="D629" /incds=0 /nref=96 /ntot=135 /MaxReadThrough="3.50613" /MaxDrop="9.07209" /score="5.30186633" /energy="-11.6" /TU="U935" /idTUdmin="U933" /TUdmin=89 /isTUend="FALSE" /label="downshifts" CDS complement(1152052..1152951) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiol management effector of SpxA degradation" /protein_id="NP_389037.2" /db_xref="EnsemblGenomes-Gn:BSU11550" /db_xref="EnsemblGenomes-Tr:CAB13012" /db_xref="GOA:O31606" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13137" /db_xref="UniProtKB/Swiss-Prot:O31606" /translation="MTNYQHELYFAHCHGHPKKPLEIYMFVDPLCPECWSLEPVIKKL KIRYGRFFTLRIIASASLTALNKKRKKHLLAEAWEKIASRSGMSCDGNVWFEQDQPLS SPYMAALAFKAAELQGRKAGMQFLRNMQESLFVSKKNITDENVLLEIAENTSLDLEEF KKDLHSQSAVKALQCDMKIAAEMDVSVNPTLTFFNTQHEDEGLKVPGSYSYDVYEEIL FEMLGDEPKPSETPPLECFIEYFRFVASKEIALVYDLSLEEVEKEMKKLAFAKKVAKV EAKHGMFWKSLSTYSDEYQSCEK*" /label="spxH CDS" gene complement(1152052..1152951) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /label="spxH gene" downshifts complement(1152083) /Source="Nicolas_upshifts" /id="D630" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="3.70729" /MaxDrop="5.65601" /score="17.9327625" /energy="-13.3" /TU="U937" /idTUdmin="U937" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1152287..1152292 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1152299 /Source="Nicolas_upshifts" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1152308..1152326 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1152315..1154216 /Source="Nicolas_S_feature" /locus_tag="new_1233877_1235778" /HighExp="S6, S4, S5, S8, S3, S7, BT, B36, C30, T5.0H" /AntisenseName="yjbH" /AntisenseCor="-0.61019541931037402" /AntisenseRegPval="-28.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S416" CDS complement(1152948..1153346) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15866723, 17293416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol management oxidoreductase component" /protein_id="NP_389038.1" /db_xref="EnsemblGenomes-Gn:BSU11560" /db_xref="EnsemblGenomes-Tr:CAB13013" /db_xref="GOA:O31607" /db_xref="InterPro:IPR001486" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR019795" /db_xref="PDB:1UX8" /db_xref="SubtiList:BG13138" /db_xref="UniProtKB/Swiss-Prot:O31607" /translation="MGQSFNAPYEAIGEELLSQLVDTFYERVASHPLLKPIFPSDLTE TARKQKQFLTQYLGGPPLYTEEHGHPMLRARHLPFPITNERADAWLSCMKDAMDHVGL EGEIREFLFGRLELTARHMVNQTEAEDRSS*" /label="yjbI CDS" gene complement(1152948..1153346) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /label="yjbI gene" S_feature complement(1153347..1153526) /Source="Nicolas_S_feature" /locus_tag="new_1234909_1235088_c" /HighExp="Diami, dia5, dia15, Etha, H2O2, C90, LoTm, Heat, Salt, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.999" /label="S417" promotor_-10 complement(1153518..1153537) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1153526) /Source="Nicolas_upshifts" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1153549..1153556) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1153601..1154146) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /EC_number="3.2.1.-" /EC_number="3.2.1.17" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:20609359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20609359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional muramidase and murein lytic transglycosylase" /protein_id="NP_389039.1" /db_xref="EnsemblGenomes-Gn:BSU11570" /db_xref="EnsemblGenomes-Tr:CAB13014" /db_xref="GOA:O31608" /db_xref="InterPro:IPR000189" /db_xref="InterPro:IPR008258" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13139" /db_xref="UniProtKB/Swiss-Prot:O31608" /translation="MLNSANTTAPSLLSAYGLNSYTSSNSGSVTKAAESTETAVADSA SNKHEANQIRSGDFSIDSAIKKAADKYGVDEKLIRAVIKQESGFNAKAVSGAGAMGLM QLMPSTASSLGVSNPLDPQQNVEGGTKYLKQMLDKYDGNVSMALAAYNAGPGNVDRYG GIPPFQETQNYVKKITSVYYA*" /label="cwlQ CDS" gene complement(1153601..1154146) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /label="cwlQ gene" downshifts complement(1153625) /Source="Nicolas_upshifts" /id="D631" /incds=0 /nref=101 /ntot=222 /MaxReadThrough="4.1014" /MaxDrop="5.00847" /score="6.97790581" /energy="-9.1" /TU="U938,U939" /idTUdmin="U938" /TUdmin="-90" /isTUend="FALSE" /label="downshifts" S_feature complement(1154147..1154349) /Source="Nicolas_S_feature" /locus_tag="new_1235709_1235911_c" /HighExp="T0.30H, Gly, C90, GM 10, GM 45, M0t90, Lbstat, C30, Lbtran, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S418" CDS complement(1154350..1154922) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9642185, 12456267, 16905149, 20509597, 26904951, 27881678; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative RNA/thiamine triphosphatase" /protein_id="NP_389040.1" /db_xref="EnsemblGenomes-Gn:BSU11580" /db_xref="EnsemblGenomes-Tr:CAB13015" /db_xref="GOA:O31609" /db_xref="InterPro:IPR009195" /db_xref="InterPro:IPR023577" /db_xref="InterPro:IPR033469" /db_xref="SubtiList:BG13140" /db_xref="UniProtKB/Swiss-Prot:O31609" /translation="MSQEIEIEFKNMLTKQEFKNIASALQLTEKDFTDQKNHYFDTDS FALKQKHAALRIRRKNGKYVLTLKEPADVGLLETHQQLSEVSDLAGFSVPEGPVKDQL HKLQIDTDAIQYFGSLATNRAEKETEKGLIVLDHSRYLNKEDYEIEFEAADWHEGRQA FEKLLQQFSIPQRETKNKILRFYEEKRKSI*" /label="yjbK CDS" gene complement(1154350..1154922) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /label="yjbK gene" promotor_-10 complement(1154495..1154513) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1154504) /Source="Nicolas_upshifts" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="upshifts" promotor_-35 complement(1154526..1154533) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" promotor_-10 complement(1154951..1154970) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1154968) /Source="Nicolas_upshifts" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="upshifts" promotor_-35 1154984..1154987 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1154985..1154992) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" upshifts 1155000 /Source="Nicolas_upshifts" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1155003..1155022 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1155047..1155415 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389041.1" /db_xref="EnsemblGenomes-Gn:BSU11590" /db_xref="EnsemblGenomes-Tr:CAB13016" /db_xref="InterPro:IPR020908" /db_xref="SubtiList:BG13141" /db_xref="UniProtKB/Swiss-Prot:O31610" /translation="MQNRIEILNATLSDDQLRLACQTEGNEAERKPSGQMLVDSDHFA FVYILELADSFEYVIIKEHVWPELKQAHAQKIPVVLEAGDQTIELAGLHEELEYLLEN IKDNANYGEEMEEKVKRVFL*" /label="yjbL CDS" gene 1155047..1155415 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /label="yjbL gene" CDS 1155444..1156079 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /EC_number="2.7.6.5" /function="16.1: Circulate" /function="16.14: Store" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 24163341, 25331430, 26825398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 24163341, 25331430, 26825398; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_389042.1" /db_xref="EnsemblGenomes-Gn:BSU11600" /db_xref="EnsemblGenomes-Tr:CAB13017" /db_xref="GOA:O31611" /db_xref="InterPro:IPR007685" /db_xref="PDB:5DEC" /db_xref="PDB:5DED" /db_xref="PDB:5F2V" /db_xref="SubtiList:BG13142" /db_xref="UniProtKB/Swiss-Prot:O31611" /translation="MDDKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVT GRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVV DQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLNYK YSGNIPEKVKLRLQRASEAASRLDEEMSEIRGEVQEAQAAFSRKKKGSEQQ*" /label="relP CDS" gene 1155444..1156079 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /label="relP gene" CDS 1156098..1156898 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /EC_number="2.7.1.23" /function="16.14: Store" /function="16.7: Manage energy" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12897004, 16233726, 16511117, 18720024, 24048943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12897004, 16233726, 16511117, 18720024, 24048943; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase (quinolate activated)" /protein_id="NP_389043.1" /db_xref="EnsemblGenomes-Gn:BSU11610" /db_xref="EnsemblGenomes-Tr:CAB13018" /db_xref="GOA:O31612" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13143" /db_xref="UniProtKB/Swiss-Prot:O31612" /translation="MKFAVSSKGDQVSDTLKSKIQAYLLDFDMELDENEPEIVISVGG DGTLLYAFHRYSDRLDKTAFVGVHTGHLGFYADWVPHEIEKLVLAIAKTPYHTVEYPL LEVIVTYHENEREERYLALNECTIKSIEGSLVADVEIKGQLFETFRGDGLCLSTPSGS TAYNKALGGAIIHPSIRAIQLAEMASINNRVFRTVGSPLLLPSHHDCMIKPRNEVDFQ VTIDHLTLLHKDVKSIRCQVASEKVRFARFRPFPFWKRVQDSFIGKGE*" /label="ppnKA CDS" gene 1156098..1156898 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /label="ppnKA gene" CDS 1156961..1157812 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /EC_number="5.4.99.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389044.1" /db_xref="EnsemblGenomes-Gn:BSU11620" /db_xref="EnsemblGenomes-Tr:CAB13019" /db_xref="GOA:O31613" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG13144" /db_xref="UniProtKB/Swiss-Prot:O31613" /translation="MTVKEYAGELGISKRLLTDIKFGGGDLQINGEHVTVKYVLKEGD LLIVKFPEEQVSETLLAEPVPLDILYEDEHVLVINKQPYVSSIPSREHPSGSIANGII DHYQTTGVRATVHLVTRLDRDTSGIMLVAKHRFAHSILSSAQKNGLVKRRYAAVVHGR MAQMEGTVDAPIGRHPDSIIERTVTPDGQKAVTHFYVTCANDDMTSVALQLETGRTHQ IRVHMSYLGHPLCGDTLYGGTRQEIGRQALHSEHLSFIHPLTQENMRFHAPLPQDMSK LIKGENH*" /label="yjbO CDS" gene 1156961..1157812 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /label="yjbO gene" downshifts 1157771 /Source="Nicolas_upshifts" /id="D632" /incds=0 /nref=203 /ntot=256 /MaxReadThrough="0.25796" /MaxDrop="5.73002" /score="21.4914497" /energy="-12.8" /TU="NA" /idTUdmin="U940" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1157825..1158559) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /EC_number="3.6.1.17" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12059787, 16740944, 21092197, 23824080, 28516732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12059787, 16740944, 21092197, 23824080, 28516732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphorylated protein phosphatase E and diadenosine-polyphosphate hydrolase" /protein_id="NP_389045.1" /db_xref="EnsemblGenomes-Gn:BSU11630" /db_xref="EnsemblGenomes-Tr:CAB13020" /db_xref="GOA:O31614" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR023937" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13145" /db_xref="UniProtKB/Swiss-Prot:O31614" /translation="MAYDIISDIHGCYDEMTALIQKLGYTIKNGVPVHEEGRVLVFAG DLTDRGPKSIEVIRFVAGAYEKGAVRYVPGNHCNKLYRYLKGNPVKVMHGLETTAAEL EELSKDEKKSVSEQFMKLYETAPLYDILHNGELVVAHAGIRADDIGKYTRRVKDFVLY GDVTGETYPDGRPIRRDWAAAYNGKAWVVYGHTPVKEPRKVNRTINIDTGCVFGNQLT GFRFPEIETVSVPSSLPYDESRFRPI*" /label="prpE CDS" gene complement(1157825..1158559) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /label="prpE gene" downshifts complement(1157847) /Source="Nicolas_upshifts" /id="D633" /incds=0 /nref=22 /ntot=152 /MaxReadThrough="1.18091" /MaxDrop="3.57735" /score="3.24324561" /energy="-12.8" /TU="NA" /idTUdmin="U938" /TUdmin="-4312" /isTUend="FALSE" /label="downshifts" promotor_-35 1158681..1158685 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-35" promotor_-10 1158702..1158721 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-10" upshifts 1158716 /Source="Nicolas_upshifts" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="upshifts" S_feature 1158717..1158793 /Source="Nicolas_S_feature" /locus_tag="new_1240279_1240355" /HighExp="H2O2, Diami, dia15, Paraq, Oxctl, Heat, G180, Salt, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S419" CDS 1158794..1160638 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 21742892, 24330391; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gated K+/H+ antiporter" /protein_id="NP_389046.1" /db_xref="EnsemblGenomes-Gn:BSU11640" /db_xref="EnsemblGenomes-Tr:CAB13021" /db_xref="GOA:O31615" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13146" /db_xref="UniProtKB/Swiss-Prot:O31615" /translation="MAHTSVASLVVVLIVAFLTPILLHRFKLSIPVVVAEIIMGLIIG KSGLNLVVEGDTWLQTLSMLGFIFLMFLSGLEIDFSSFEKGKKKQFLPNGKEAPNTFA AASVIFVGIFILSLLLSYGFVLAGFIQNAFLMTLIISTISLGVVVPTLKEERIMNSNI GQIILLVAVIADLATMILLAVFSSLYGEDSGNMWLLMILFAAGVVLYFFGRVFKHRSF VQSMSKGTIQIGTRAIFTLIIVLVALSESLGAENILGAFLAGVLVSLLSPNKELVQQL DSFGYGFLIPIFFVMVGVKLDIWTLFQDKTILIMIPLLLLALLVSKIIPVMYLKKWYD NRTIFASGFLLTSTLSLVIAAATIGQQLHVISTNMSGALILVAVIASIFTPICFKKLY KREEQPEEKKTITFIGANQMTLPVTLELPEEEYDVRVVHVYQENAEEKLSESVFAVET ISDYEHETLESLGIFETDILVVATGNEDMNADIALLAKDKGTERVIASVGSPEHEAAL KEQGISIFSILLSTKTLLRALIEAPGVMKLLTNQESSLYQINMENSKYDGVILREFPL TGDVIFVRIFRGVDSIVPHGDTRLKLGDRLIVTGSRGYVTDLKKTLEG*" /label="kefQ CDS" gene 1158794..1160638 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /label="kefQ gene" misc_feature complement(1159121..1159140) /Source="Nicolas_upshift_promotors" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1159145) /Source="Nicolas_upshifts" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1160640..1160647 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-35" promotor_-10 1160661..1160680 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-10" upshifts 1160667 /Source="Nicolas_upshifts" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="upshifts" misc_RNA 1160700..1160808 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswA RNA" gene 1160700..1160808 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /label="tswA gene" downshifts 1160803 /Source="Nicolas_upshifts" /id="D634" /incds=0 /nref=20 /ntot=84 /MaxReadThrough="7.67021" /MaxDrop="5.27759" /score="34.8346124" /energy="-12.5" /TU="U943" /idTUdmin="U941" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS 1160887..1161597 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /EC_number="3.5.99.2" /function="4.11: Thiamine" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 17618314, 18054064, 24311574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 17618314, 18054064, 24311574; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiaminase II" /protein_id="NP_389047.1" /db_xref="EnsemblGenomes-Gn:BSU11650" /db_xref="EnsemblGenomes-Tr:CAB13022" /db_xref="GOA:P25052" /db_xref="InterPro:IPR004305" /db_xref="InterPro:IPR016084" /db_xref="InterPro:IPR027574" /db_xref="PDB:1TO9" /db_xref="PDB:1TYH" /db_xref="PDB:1YAF" /db_xref="PDB:1YAK" /db_xref="PDB:2QCX" /db_xref="SubtiList:BG10791" /db_xref="UniProtKB/Swiss-Prot:P25052" /translation="MKFSEECRSAAAEWWEGSFVHPFVQGIGDGTLPIDRFKYYVLQD SYYLTHFAKVQSFGAAYAKDLYTTGRMASHAQGTYEAEMALHREFAELLEISEEERKA FKPSPTAYSYTSHMYRSVLSGNFAEILAALLPCYWLYYEVGEKLLHCDPGHPIYQKWI GTYGGDWFRQQVEEQINRFDELAENSTEEVRAKMKENFVISSYYEYQFWGMAYRKEGW SDSAIKEVEECGASRHNG*" /label="tenA CDS" gene 1160887..1161597 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /label="tenA gene" CDS 1161572..1162189 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /EC_number="5.3.99.10" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 21534620" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 21534620; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiazole tautomerase" /protein_id="NP_389048.1" /db_xref="EnsemblGenomes-Gn:BSU11660" /db_xref="EnsemblGenomes-Tr:CAB13023" /db_xref="GOA:P25053" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR036206" /db_xref="PDB:1YAD" /db_xref="PDB:3QH2" /db_xref="SubtiList:BG10792" /db_xref="UniProtKB/Swiss-Prot:P25053" /translation="MELHAITDDSKPVEELARIIITIQNEVDFIHIRERSKSAADILK LLDLIFEGGIDKRKLVMNGRVDIALFSTIHRVQLPSGSFSPKQIRARFPHLHIGRSVH SLEEAVQAEKEDADYVLFGHVFETDCKKGLEGRGVSLLSDIKQRISIPVIAIGGMTPD RLRDVKQAGADGIAVMSGIFSSAEPLEAARRYSRKLKEMRYEKAL*" /label="tenI CDS" gene 1161572..1162189 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /label="tenI gene" CDS 1162173..1163282 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /EC_number="1.4.3.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9827558, 11744710, 12627963, 15105420, 19751796, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9827558, 11744710, 12627963, 15105420, 19751796, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="FAD-dependent glycine oxidase" /protein_id="NP_389049.1" /db_xref="EnsemblGenomes-Gn:BSU11670" /db_xref="EnsemblGenomes-Tr:CAB13024" /db_xref="GOA:O31616" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR012727" /db_xref="InterPro:IPR036188" /db_xref="PDB:1NG3" /db_xref="PDB:1NG4" /db_xref="PDB:1RYI" /db_xref="PDB:3IF9" /db_xref="SubtiList:BG13147" /db_xref="UniProtKB/Swiss-Prot:O31616" /translation="MKRHYEAVVIGGGIIGSAIAYYLAKENKNTALFESGTMGGRTTS AAAGMLGAHAECEERDAFFDFAMHSQRLYKGLGEELYALSGVDIRQHNGGMFKLAFSE EDVLQLRQMDDLDSVSWYSKEEVLEKEPYASGDIFGASFIQDDVHVEPYFVCKAYVKA AKMLGAEIFEHTPVLHVERDGEALFIKTPSGDVWANHVVVASGVWSGMFFKQLGLNNA FLPVKGECLSVWNDDIPLTKTLYHDHCYIVPRKSGRLVVGATMKPGDWSETPDLGGLE SVMKKAKTMLPAIQNMKVDRFWAGLRPGTKDGKPYIGRHPEDSRILFAAGHFRNGILL APATGALISDLIMNKEVNQDWLHAFRIDRKEAVQI*" /label="thiO CDS" gene 1162173..1163282 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /label="thiO gene" CDS 1163282..1163482 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 14567704, 14757766, 15489164, 22616866, 26443755; Product type c : carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier for synthesis of hydroxyethylthiazole phosphate" /protein_id="NP_389050.1" /db_xref="EnsemblGenomes-Gn:BSU11680" /db_xref="EnsemblGenomes-Tr:CAB13025" /db_xref="GOA:O31617" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010035" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="PDB:1TYG" /db_xref="SubtiList:BG13148" /db_xref="UniProtKB/Swiss-Prot:O31617" /translation="MLQLNGKDVKWKKDTGTIQDLLASYQLENKIVIVERNKEIIGKE RYHEVELCDRDVIEIVHFVGGG*" /label="thiS CDS" gene 1163282..1163482 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /label="thiS gene" CDS 1163479..1164249 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /EC_number="2.8.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14567704, 14757766, 15489164, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14567704, 14757766, 15489164, 22938038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="hydroxyethylthiazole phosphate synthetase (thiamine biosynthesis)" /protein_id="NP_389051.1" /db_xref="EnsemblGenomes-Gn:BSU11690" /db_xref="EnsemblGenomes-Tr:CAB13026" /db_xref="GOA:O31618" /db_xref="InterPro:IPR008867" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033983" /db_xref="PDB:1TYG" /db_xref="PDB:1XM3" /db_xref="SubtiList:BG13149" /db_xref="UniProtKB/Swiss-Prot:O31618" /translation="MSMLTIGGKSFQSRLLLGTGKYPSFDIQKEAVAVSESDILTFAV RRMNIFEASQPNFLEQLDLSKYTLLPNTAGASTAEEAVRIARLAKASGLCDMIKVEVI GCSRSLLPDPVETLKASEQLLEEGFIVLPYTSDDVVLARKLEELGVHAIMPGASPIGS GQGILNPLNLSFIIEQAKVPVIVDAGIGSPKDAAYAMELGADGVLLNTAVSGADDPVK MARAMKLAVEAGRLSYEAGRIPLKQYGTASSPGEGLPV*" /label="thiG CDS" gene 1163479..1164249 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /label="thiG gene" CDS 1164246..1165256 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /EC_number="2.7.7.73" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14567704, 14757766, 15489164, 16388576, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14567704, 14757766, 15489164, 16388576, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate transferase and sulfur transferase (thiamine biosynthesis)" /protein_id="NP_389052.1" /db_xref="EnsemblGenomes-Gn:BSU11700" /db_xref="EnsemblGenomes-Tr:CAB13027" /db_xref="GOA:O31619" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13150" /db_xref="UniProtKB/Swiss-Prot:O31619" /translation="MTGRYSRQELFAPIGPSGQKKLKEARAVIIGAGALGTASAEMLV RAGVGSVKIADRDYVEWSNLQRQQLYTEDDVKKEMPKAAAAERRLRSINSDVDVTGLV MDVTAENIFELIRDASIIVDAADNFETRLIVNDAAVKEGIPFLYGACVGSYGLTFTVV PGSTPCLHCLLDALPIGGATCDTAGIISPAVLQVAVFQVTDALKLLTGEECEPVLRSF DLWKNERSEVRAASLKHDACPSCGTKDFPFLSYENQTKAAVLCGRNTVQIRSSITKEA DLEALAGQLRQAGLEVAANPYLISCRSDDMKMVLFRDGRALIHGTNDIARAKSIYHKW IG*" /label="thiF CDS" gene 1164246..1165256 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /label="thiF gene" CDS 1165275..1166090 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /EC_number="2.7.4.7" /EC_number="2.7.1.49" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14973012, 16952958, 17012797, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14973012, 16952958, 17012797, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine kinase, 4-amino-5-hydroxymethyl-2-methylpyrimidine and 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate kinase" /protein_id="NP_389053.1" /db_xref="EnsemblGenomes-Gn:BSU11710" /db_xref="EnsemblGenomes-Tr:CAB13028" /db_xref="GOA:O31620" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13151" /db_xref="UniProtKB/Swiss-Prot:O31620" /translation="MSIYKALTIAGSDSGGGAGIQADIKTFQELDVFGMSAITAVTAQ NTLGVHGVHPLTVETLRQQIDAVAEDLRPDAVKTGMLWNADMIEEVARKIDEYGFNRV IVDPVMIAKGGASLLRDESVATLKELLIPRSYAITPNVPEAETLTGMTISSLDDRKKA AEQLVKMGAQHVIIKGGHQPEDNHITDLLFDGSMFMQITHPYINTKHTHGTGCTFAAA LTAQTAKGDSIHQAFEVAANFVREAVENTLGIGSGHGPTNHFAFKRNSLNTSR*" /label="thiD CDS" gene 1165275..1166090 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /label="thiD gene" downshifts 1166064 /Source="Nicolas_upshifts" /id="D635" /incds=0 /nref=128 /ntot=172 /MaxReadThrough="3.33485" /MaxDrop="5.0154" /score="3.40314581" /energy="-14.8" /TU="U943" /idTUdmin="U943" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1166137..1166143 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1166156..1166175 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1166166 /Source="Nicolas_upshifts" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="upshifts" CDS 1166226..1167002 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /EC_number="1.3.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 15105103, 21185310, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 15105103, 21185310, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase" /protein_id="NP_389054.2" /db_xref="EnsemblGenomes-Gn:BSU11720" /db_xref="EnsemblGenomes-Tr:CAB13029" /db_xref="GOA:P54616" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR014358" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIF" /db_xref="PDB:3OIG" /db_xref="SubtiList:BG13152" /db_xref="UniProtKB/Swiss-Prot:P54616" /translation="MNFSLEGRNIVVMGVANKRSIAWGIARSLHEAGARLIFTYAGER LEKSVHELAGTLDRNDSIILPCDVTNDAEIETCFASIKEQVGVIHGIAHCIAFANKEE LVGEYLNTNRDGFLLAHNISSYSLTAVVKAARPMMTEGGSIVTLTYLGGELVMPNYNV MGVAKASLDASVKYLAADLGKENIRVNSISAGPIRTLSAKGISDFNSILKDIEERAPL RRTTTPEEVGDTAAFLFSDMSRGITGENLHVDSGFHITAR*" /label="fabI CDS" gene 1166226..1167002 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /label="fabI gene" downshifts 1166991 /Source="Nicolas_upshifts" /id="D636" /incds=0 /nref=229 /ntot=313 /MaxReadThrough="3.12901" /MaxDrop="6.64182" /score="33.5478109" /energy="-11.8" /TU="U944" /idTUdmin="U944" /TUdmin="-416" /isTUend="FALSE" /label="downshifts" promotor_-35 1167050..1167055 /Source="Nicolas_upshift_promotors" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1167071..1167089 /Source="Nicolas_upshift_promotors" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1167075 /Source="Nicolas_upshifts" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1167087..1167101) /Source="Nicolas_upshift_promotors" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1167087) /Source="Nicolas_upshifts" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1167103..1167786 /gene="cotO" /locus_tag="BSU_11730" /old_locus_tag="BSU11730" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16321932" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore outer coat protein" /protein_id="NP_389055.1" /db_xref="EnsemblGenomes-Gn:BSU11730" /db_xref="EnsemblGenomes-Tr:CAB13030" /db_xref="GOA:O31622" /db_xref="InterPro:IPR025439" /db_xref="SubtiList:BG13153" /db_xref="UniProtKB/Swiss-Prot:O31622" /translation="MKMSNKKRNADKKPLMYIVQPDYAETTRSSMQEIVIKRKADKPA PPKAEEKPAYHEKQQEEAVAQDVLQEDQKPAAEPVSQQTQEAREPENIKSQEEQKAEP QAVEETVEHEPPKAEKKEEPALEARKPEKEPEAVHSADKAEEKAPPARKVKKPMSKMT IHEKIDFLTKLPHNMPRALCLIEANGRTYRGVIVGRRNDSVLLRTTGNGAPTELAIDD ITSLHPLGF*" /label="cotO CDS" gene 1167103..1167786 /gene="cotO" /locus_tag="BSU_11730" /old_locus_tag="BSU11730" /label="cotO gene" promotor_-35 complement(1167109..1167113) /Source="Nicolas_upshift_promotors" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1167781 /Source="Nicolas_upshifts" /id="D637" /incds=0 /nref=4 /ntot=40 /MaxReadThrough="3.37645" /MaxDrop="4.6587" /score="18.0229289" /energy="-13.4" /TU="U945" /idTUdmin="U945" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 1167869 /Source="Nicolas_upshifts" /id="D638" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.44926" /MaxDrop="4.55934" /score="18.0229289" /energy="-13.4" /TU="NA" /idTUdmin="U945" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1167880..1168326) /gene="cotZ" /locus_tag="BSU_11740" /old_locus_tag="BSU11740" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 19933362, 26341943, 27320701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 19933362, 26341943, 27320701; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction, crust layer)" /protein_id="NP_389056.1" /db_xref="EnsemblGenomes-Gn:BSU11740" /db_xref="EnsemblGenomes-Tr:CAB13031" /db_xref="GOA:Q08312" /db_xref="InterPro:IPR019593" /db_xref="SubtiList:BG10499" /db_xref="UniProtKB/Swiss-Prot:Q08312" /translation="MSQKTSSCVREAVENIEDLQNAVEEDCPTGCHSKLLSVSHSLGD TVPFAIFTSKSTPLVAFGNVGELDNGPCFNTVFFRVERVHGSCATLSLLIAFDEHKHI LDFTDKDTVCEVFRLEKTNYCIEVDLDCFCAINCLNPRLINRTHHH*" /label="cotZ CDS" gene complement(1167880..1168326) /gene="cotZ" /locus_tag="BSU_11740" /old_locus_tag="BSU11740" /label="cotZ gene" downshifts complement(1167901) /Source="Nicolas_upshifts" /id="D639" /incds=0 /nref=7 /ntot=50 /MaxReadThrough="8.44444" /MaxDrop="7.17581" /score="2.03943557" /energy="-9.3" /TU="U949" /idTUdmin="U950" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1168327..1168453) /Source="Nicolas_S_feature" /locus_tag="new_1249889_1250015_c" /HighExp="S8, S7, S6, BT, S5, B36, G/S, Pyr, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigEF" /TUshortPSig="1, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S420" CDS complement(1168454..1168942) /gene="cotY" /locus_tag="BSU_11750" /old_locus_tag="BSU11750" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 14766913, 26341943, 26821119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 14766913, 26341943, 26821119; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="outer spore coat protein (crust layer, insolublefraction)" /protein_id="NP_389057.1" /db_xref="EnsemblGenomes-Gn:BSU11750" /db_xref="EnsemblGenomes-Tr:CAB13032" /db_xref="GOA:Q08311" /db_xref="InterPro:IPR019593" /db_xref="SubtiList:BG10498" /db_xref="UniProtKB/Swiss-Prot:Q08311" /translation="MSCGKTHGRHENCVCDAVEKILAEQEAVEEQCPTGCYTNLLNPT IAGKDTIPFLVFDKKGGLFSTFGNVGGFVDDMQCFESIFFRVEKLCDCCATLSILRPV DVKGDTLSVCHPCDPDFFGLEKTDFCIEVDLGCFCAIQCLSPELVDRTSPHKDKKHHH NG*" /label="cotY CDS" gene complement(1168454..1168942) /gene="cotY" /locus_tag="BSU_11750" /old_locus_tag="BSU11750" /label="cotY gene" promotor_-35 1168622..1168628 /Source="Nicolas_upshift_promotors" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1168643..1168662 /Source="Nicolas_upshift_promotors" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1168661 /Source="Nicolas_upshifts" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1168938..1168942 /Source="Nicolas_upshift_promotors" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1168951..1168965 /Source="Nicolas_upshift_promotors" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1168969 /Source="Nicolas_upshifts" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1168979..1168998) /Source="Nicolas_upshift_promotors" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1168996) /Source="Nicolas_upshifts" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1169012..1169021) /Source="Nicolas_upshift_promotors" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1169028..1169046) /Source="Nicolas_upshift_promotors" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1169045) /Source="Nicolas_upshifts" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1169062..1169067) /Source="Nicolas_upshift_promotors" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1169079 /Source="Nicolas_upshifts" /id="D640" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="1.28604" /MaxDrop="4.18677" /score="-9.76125107" /energy="-10.4" /TU="NA" /idTUdmin="U948" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1169094..1169612) /gene="cotX" /locus_tag="BSU_11760" /old_locus_tag="BSU11760" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 10400595, 10788508, 12031481, 19304857, 26821119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 10400595, 10788508, 12031481, 19304857, 26821119; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction)" /protein_id="NP_389058.1" /db_xref="EnsemblGenomes-Gn:BSU11760" /db_xref="EnsemblGenomes-Tr:CAB13033" /db_xref="GOA:Q08313" /db_xref="InterPro:IPR011428" /db_xref="SubtiList:BG10500" /db_xref="UniProtKB/Swiss-Prot:Q08313" /translation="MESRPYSWVALDPDCDHPLDDKEKDKEKHERKCHCDVCCNGNGF FGNDNAFIDQDLAQANLNKQVSDETIIIRDSCDINVTSTDVQAVTSVVTALNAAVVTA TLTSIADGVIAELVAQDLLQLTANKQVNRQKLLIECSRGVNVTTVDADIATLISTATN TLVAILVITLVL*" /label="cotX CDS" gene complement(1169094..1169612) /gene="cotX" /locus_tag="BSU_11760" /old_locus_tag="BSU11760" /label="cotX gene" downshifts complement(1169118) /Source="Nicolas_upshifts" /id="D641" /incds=0 /nref=76 /ntot=102 /MaxReadThrough="1.79219" /MaxDrop="8.69761" /score="18.5755652" /energy="-10.4" /TU="U952" /idTUdmin="U952" /TUdmin="-29" /isTUend="FALSE" /label="downshifts" downshifts 1169123 /Source="Nicolas_upshifts" /id="D642" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="1.2156" /MaxDrop="3.69222" /score="-9.76125107" /energy="-10.4" /TU="NA" /idTUdmin="U948" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature complement(1169613..1169710) /Source="Nicolas_S_feature" /locus_tag="new_1251175_1251272_c" /HighExp="S8, S7, S6, BT, B36, G/S, Pyr, S5, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.748" /TUlongSig="SigK" /TUlongPSig="0.98" /label="S421" CDS complement(1169711..1170028) /gene="cotW" /locus_tag="BSU_11770" /old_locus_tag="BSU11770" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8509331, 19304857, 21665972, 25872412" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8509331, 19304857, 21665972, 25872412; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (outemost layer)" /protein_id="NP_389059.1" /db_xref="EnsemblGenomes-Gn:BSU11770" /db_xref="EnsemblGenomes-Tr:CAB13034" /db_xref="GOA:Q08310" /db_xref="SubtiList:BG10497" /db_xref="UniProtKB/Swiss-Prot:Q08310" /translation="MSDNDKFKEELAKLPEVDPMTKMLVQNIFSKHGVTKDKMKKVSD EEKEMLLNLVKDLQAKSQALIENQKKKKEEAAAQEQKNTKPLSRREQLIEQIRQRRKN DNN*" /label="cotW CDS" gene complement(1169711..1170028) /gene="cotW" /locus_tag="BSU_11770" /old_locus_tag="BSU11770" /label="cotW gene" CDS complement(1170069..1170455) /gene="cotV" /locus_tag="BSU_11780" /old_locus_tag="BSU11780" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction)" /protein_id="NP_389060.1" /db_xref="EnsemblGenomes-Gn:BSU11780" /db_xref="EnsemblGenomes-Tr:CAB13035" /db_xref="GOA:Q08309" /db_xref="InterPro:IPR011428" /db_xref="SubtiList:BG10496" /db_xref="UniProtKB/Swiss-Prot:Q08309" /translation="MSFEEKVESLHPAIFEQLSSEFEQQIEVIDCENITIDTSHITAA LSIQAFVTTMIIVATQLVIADEDLADAVASEILILDSSQIKKRTIIKIINSRNIKITL SADEIITFVQILLQVLNSILSELDVL*" /label="cotV CDS" gene complement(1170069..1170455) /gene="cotV" /locus_tag="BSU_11780" /old_locus_tag="BSU11780" /label="cotV gene" promotor_-35 1170451..1170455 /Source="Nicolas_upshift_promotors" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1170463..1170477 /Source="Nicolas_upshift_promotors" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1170465 /Source="Nicolas_upshifts" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1170475..1170494) /Source="Nicolas_upshift_promotors" /id="U952" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.748251748251748" /psig="0.748251748251748" /xcortree=1351 /SigmaFactorBS="catgaattgtatcttgtccggcagaaaattggttatttttat taTtCcGctctgcaccccattTGCATTATATAGAGTATGGAtaagaaaggagtgaagg t" /listShort="cotV, cotW, S421, cotX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1170497) /Source="Nicolas_upshifts" /id="U952" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.748251748251748" /psig="0.748251748251748" /xcortree=1351 /SigmaFactorBS="catgaattgtatcttgtccggcagaaaattggttatttttat taTtCcGctctgcaccccattTGCATTATATAGAGTATGGAtaagaaaggagtgaagg t" /listShort="cotV, cotW, S421, cotX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1170499..1171003) /Source="Nicolas_S_feature" /locus_tag="new_1252061_1252565_c" /HighExp="S8, S6, S7, BT, S5, B36, Pyr, C30, G/S, nit" /AntisenseName="yjcA" /AntisenseCor="0.69838474492609404" /AntisenseRegPval="-39.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S422" promotor_-35 1170552..1170557 /Source="Nicolas_upshift_promotors" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" /label="promotor_-35" promotor_-10 1170573..1170591 /Source="Nicolas_upshift_promotors" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" /label="promotor_-10" upshifts 1170575 /Source="Nicolas_upshifts" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" /label="upshifts" CDS 1170615..1170971 /gene="yjcA" /locus_tag="BSU_11790" /old_locus_tag="BSU11790" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132, 15849754, 16850406; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein" /protein_id="NP_389061.1" /db_xref="EnsemblGenomes-Gn:BSU11790" /db_xref="EnsemblGenomes-Tr:CAB13036" /db_xref="GOA:O31623" /db_xref="InterPro:IPR010773" /db_xref="SubtiList:BG13154" /db_xref="UniProtKB/Swiss-Prot:O31623" /translation="MVINGLTIVLLSLAVFRLARLLVFDTIMAPLRSLFHEEKEEKDA DGNIETYIVIKGTGVRAFIGELLSCYWCTGVWCAGFLILCQAVIPQAAQWLILLLAIA GLAGIIETLVSKWLQE*" /label="yjcA CDS" gene 1170615..1170971 /gene="yjcA" /locus_tag="BSU_11790" /old_locus_tag="BSU11790" /label="yjcA gene" promotor_-35 1170981..1170990 /Source="Nicolas_upshift_promotors" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" /label="promotor_-35" promotor_-10 complement(1170988..1171007) /Source="Nicolas_upshift_promotors" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" /label="promotor_-10" CDS complement(1170996..1171229) /locus_tag="BSU_11798" /old_locus_tag="BSU11798" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="protein remnant" /db_xref="PSEUDO:SOX90549.1" /translation="MLSETASLKKQKTGVLRFLCQAIEAFSFYFRTRSLSFLSFLIDT MNLYMEIFGKVYDADSFLSPSFPYVIYATLCVF*" /label="protein remnant CDS" gene complement(1170996..1171229) /locus_tag="BSU_11798" /old_locus_tag="BSU11798" /pseudo /label="gene" upshifts complement(1171003) /Source="Nicolas_upshifts" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" /label="upshifts" S_feature 1171004..1171190 /Source="Nicolas_S_feature" /locus_tag="new_1252566_1252752" /HighExp="S8, S6, S7, BT, S5, B36, S4, S3, G/S, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.26970100000000002" /TUshortSig="SigK, SigEF" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S423" promotor_-10 1171004..1171021 /Source="Nicolas_upshift_promotors" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" /label="promotor_-10" upshifts 1171004 /Source="Nicolas_upshifts" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" /label="upshifts" promotor_-35 complement(1171021..1171030) /Source="Nicolas_upshift_promotors" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" /label="promotor_-35" downshifts complement(1171047) /Source="Nicolas_upshifts" /id="D643" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="3.12564" /MaxDrop="4.58782" /score="-6.14331629" /energy="-6.8" /TU="NA" /idTUdmin="U954" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" downshifts 1171147 /Source="Nicolas_upshifts" /id="D644" /incds=0 /nref=3 /ntot=32 /MaxReadThrough="5.73879" /MaxDrop="3.6919" /score="33.8150878" /energy="-6.8" /TU="U953,U955" /idTUdmin="U953" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" upshifts complement(1171201) /Source="Nicolas_upshifts" /id="U956" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.284715284715285" /psig="0.032967032967033" /xcortree=768 /SigmaFactorBS="ctcattcacttttatccccccgcttatgatatatgctgagcg agaCCGCCTCGttaaaaaaacaaaaaaccggagttctccggtttctttgccaggctat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1171202..1171211 /Source="Nicolas_upshift_promotors" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1171209..1171216) /Source="Nicolas_upshift_promotors" /id="U956" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.284715284715285" /psig="0.032967032967033" /xcortree=768 /SigmaFactorBS="ctcattcacttttatccccccgcttatgatatatgctgagcg agaCCGCCTCGttaaaaaaacaaaaaaccggagttctccggtttctttgccaggctat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1171225..1171244 /Source="Nicolas_upshift_promotors" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1171235 /Source="Nicolas_upshifts" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="upshifts" CDS 1171253..1171459 /gene="yjzK" /locus_tag="BSU_11799" /old_locus_tag="BSU11799" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097704.1" /db_xref="EnsemblGenomes-Gn:BSU11799" /db_xref="EnsemblGenomes-Tr:CAX52594" /db_xref="UniProtKB/Swiss-Prot:C0H3Y7" /translation="MNEFEKWIEGRYEPHEQKQKEHEDTMGSIRKDLDAFDKAGLEFE DEIEELAEKTEALLKKHQAQYDQS*" /label="yjzK CDS" gene 1171253..1171459 /gene="yjzK" /locus_tag="BSU_11799" /old_locus_tag="BSU11799" /label="yjzK gene" CDS 1171296..1171511 /gene="yjcB" /locus_tag="BSU_11800" /old_locus_tag="BSU11800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein" /protein_id="YP_009513951.1" /translation="MNKSKKSMKTRWAVSEKTWMHLIKPVWNLKMRLKSWLKKRRPYL KNIKLNMINRKSANALCEYPSRSQQLT*" /label="yjcB CDS" gene 1171296..1171511 /gene="yjcB" /locus_tag="BSU_11800" /old_locus_tag="BSU11800" /label="yjcB gene" promotor_-35 1171483..1171492 /Source="Nicolas_upshift_promotors" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1171505..1171524 /Source="Nicolas_upshift_promotors" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1171510 /Source="Nicolas_upshifts" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1171517..1171531) /Source="Nicolas_upshift_promotors" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1171531) /Source="Nicolas_upshifts" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1171541..1171545) /Source="Nicolas_upshift_promotors" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1171541..1171690 /gene="yjcZ" /locus_tag="BSU_11809" /old_locus_tag="BSU11809" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523132, 20156992, 21670523; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097705.1" /db_xref="EnsemblGenomes-Gn:BSU11809" /db_xref="EnsemblGenomes-Tr:CAX52595" /db_xref="GOA:C0H3Y8" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Y8" /translation="MGFGYGFGGGYGGGCYGGYAGGYGGGYGSTFVLLVVLFILLIIV GASFF*" /label="yjcZ CDS" gene 1171541..1171690 /gene="yjcZ" /locus_tag="BSU_11809" /old_locus_tag="BSU11809" /label="yjcZ gene" downshifts 1171631 /Source="Nicolas_upshifts" /id="D645" /incds=0 /nref=4 /ntot=29 /MaxReadThrough="8.16203" /MaxDrop="4.48861" /score="1.53429015" /energy="-22.4" /TU="U957,U958" /idTUdmin="U955" /TUdmin=110 /isTUend="FALSE" /label="downshifts" S_feature 1171691..1171822 /Source="Nicolas_S_feature" /locus_tag="new_1253253_1253384" /HighExp="S7, BT, S8, B36, S6, G/S, Pyr, B60, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigK" /TUshortPSig="1, 0.971" /TUlongSig="SigK, SigEF" /TUlongPSig="0.999, 1" /label="S424" CDS 1171823..1172077 /gene="spoVIF" /locus_tag="BSU_11810" /old_locus_tag="BSU11810" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132, 14702409, 20435725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132, 14702409, 20435725; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein needed for heat resistance" /protein_id="NP_389063.2" /db_xref="EnsemblGenomes-Gn:BSU11810" /db_xref="EnsemblGenomes-Tr:CAB13038" /db_xref="GOA:O31625" /db_xref="InterPro:IPR025942" /db_xref="SubtiList:BG13156" /db_xref="UniProtKB/Swiss-Prot:O31625" /translation="MDNQFFKNIEKKTGVKMQDVMNLAGSLQNANFKDENTVRSVINR VAQMANRRVPKELEDKIVESITSGKEKLDFGTISKMMDNK*" /label="spoVIF CDS" gene 1171823..1172077 /gene="spoVIF" /locus_tag="BSU_11810" /old_locus_tag="BSU11810" /label="spoVIF gene" downshifts 1172062 /Source="Nicolas_upshifts" /id="D646" /incds=0 /nref=40 /ntot=79 /MaxReadThrough="5.66609" /MaxDrop="5.8411" /score="7.68851688" /energy="-10.7" /TU="U957,U958" /idTUdmin="U955" /TUdmin=541 /isTUend="FALSE" /label="downshifts" downshifts complement(1172081) /Source="Nicolas_upshifts" /id="D647" /incds=0 /nref=3 /ntot=9 /MaxReadThrough="3.12148" /MaxDrop="4.34051" /score="24.4726468" /energy="-14.3" /TU="NA" /idTUdmin="U961" /TUdmin=88 /isTUend="FALSE" /label="downshifts" S_feature 1172107..1173207 /Source="Nicolas_S_feature" /locus_tag="new_1253669_1254769" /HighExp="S8, S6, S7, B36, S5, C30, BT, dia15, Diami, H2O2" /AntisenseName="yjcD" /AntisenseCor="-0.210610370451118" /AntisenseRegPval="-3.3" /CDS_PredictionProba="0.18426200000000001" /TUshortSig="SigK, SigK" /TUshortPSig="1, 0.971" /TUlongSig="SigK, SigEF" /TUlongPSig="0.999, 1" /label="S425" CDS complement(1172151..1174430) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544244, 16014871, 17114254, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent DNA helicase (sporulationassociated)" /protein_id="NP_389064.3" /db_xref="EnsemblGenomes-Gn:BSU11820" /db_xref="EnsemblGenomes-Tr:CAB13039" /db_xref="GOA:O31626" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG13157" /db_xref="UniProtKB/Swiss-Prot:O31626" /translation="MKCARLNDRIIHLHTYSREHYQFLFEEGIKGHLFCSHCGKPVLL RLNIADPPEFIHRQPGDFPACEEACEPKPSKEGKKEDDQESGVIRLPKGKAIAADPSP AVTEWHRPRSIKPGTPFVPKTIEPDTSLFPSVGLNTDQLKAVTETEGPLLVLAGAGSG KTRVLTARAAHMIEHLGIPPENMLLVTFTTKAVAEMKERMANQYGLQPAKVRRIVTGT FHSLFYKILYHSNSAKWNGEHLLKMEWQREQYIKKALYEEGIDEKESPVDQALQQIGF WKNTYVPNERIPLKDEWEKQVYRLYEHYERQKKEHSQFDFDDMASACYELFIERPDLL EQYQSRFTYILIDEFQDINPVQYKIMQMLASPEQNLCCVGDDDQSIYAFRGSNPSFIL DFQKDYPGAKTIYLTANYRSTHPIVSSADIVVKKNKNRYAKTLEAARDDIQVPVLFYP YDEEEEATMVVSDIKEKIQNGASPEDFAVLYRTNSGGRAIYERLHQSSIPYTADRGVQ SFYSRRIVRQILAYLYASQNEDDTEAIKHLLPALFLKQSALNTLKALSITEDCTMIKA LAKLPDLKPFQLDKIKKIVPFFASLRTMKPVEAITFAEGKMGFSEYLKKRGNEGNKLE KGSDDLRDIKVVAKKFKTIPDFLAHVDHMRAAEKNRTDEHGVQLMTIHRSKGLEFKTV YVLGTVDGSIPHDFSLETARKGDEAALEEERRLLYVAMTRAKQHLYLSCPANRRGKTA NRSRFLYPLLQKARQPLHH*" /label="yjcD CDS" gene complement(1172151..1174430) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /label="yjcD gene" downshifts complement(1172169) /Source="Nicolas_upshifts" /id="D648" /incds=0 /nref=61 /ntot=171 /MaxReadThrough="2.59869" /MaxDrop="4.36061" /score="24.4726468" /energy="-14.3" /TU="NA" /idTUdmin="U961" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1174305..1174479) /Source="Nicolas_S_feature" /locus_tag="new_1255867_1256041_c" /HighExp="G180, G135, G150, H2O2, Paraq, Oxctl, LBGexp, dia15, dia0, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S426" promotor_-35 1174358..1174366 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1174377..1174395 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1174381..1174516 /Source="Nicolas_S_feature" /locus_tag="new_1255943_1256078" /HighExp="S4, S5, S3, S6, S7, S8, M9-stat, T4.0H, T3.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S427" upshifts 1174381 /Source="Nicolas_upshifts" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1174467..1174486) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1174478) /Source="Nicolas_upshifts" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1174494..1174500 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1174502..1174506) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1174515..1174533 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1174518 /Source="Nicolas_upshifts" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="upshifts" CDS 1174547..1174801 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11976315, 23155385" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097706.1" /db_xref="EnsemblGenomes-Gn:BSU11839" /db_xref="EnsemblGenomes-Tr:CAX52596" /db_xref="UniProtKB/Swiss-Prot:C0H3Y9" /translation="MIYAGQIQNQQYAQYANRTIGHKQDYAGTEKISYVPFQRVYKEL EKQQENQTAAERKVNEMKRKRSLYKRLREKGMGTYINRYV*" /label="yjzE CDS" gene 1174547..1174801 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /label="yjzE gene" downshifts 1174777 /Source="Nicolas_upshifts" /id="D649" /incds=0 /nref=101 /ntot=248 /MaxReadThrough="3.69482" /MaxDrop="7.80206" /score="5.37568515" /energy="-6.1" /TU="U962" /idTUdmin="U960" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1174867) /Source="Nicolas_upshifts" /id="D650" /incds=0 /nref=78 /ntot=283 /MaxReadThrough="3.21062" /MaxDrop="7.8562" /score="-4.05705392" /energy="-6.1" /TU="U963" /idTUdmin="U963" /TUdmin="-36" /isTUend="FALSE" /label="downshifts" CDS complement(1174874..1175296) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389066.1" /db_xref="EnsemblGenomes-Gn:BSU11840" /db_xref="EnsemblGenomes-Tr:CAB13041" /db_xref="GOA:O31628" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1Q2Y" /db_xref="SubtiList:BG13159" /db_xref="UniProtKB/Swiss-Prot:O31628" /translation="MKAVIAKNEEQLKDAFYVREEVFVKEQNVPAEEEIDELENESEH IVVYDGEKPVGAGRWRMKDGYGKLERICVLKSHRSAGVGGIIMKALEKAAADGGASGF ILNAQTQAVPFYKKHGYRVLSEKEFLDAGIPHLQMMKD*" /label="yjcF CDS" gene complement(1174874..1175296) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /label="yjcF gene" CDS complement(1175300..1175815) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12466548, 16511078, 17012785, 18473364, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA ligase or phosphoesterase" /protein_id="NP_389067.1" /db_xref="EnsemblGenomes-Gn:BSU11850" /db_xref="EnsemblGenomes-Tr:CAB13042" /db_xref="GOA:O31629" /db_xref="InterPro:IPR009097" /db_xref="InterPro:IPR022932" /db_xref="PDB:2D4G" /db_xref="SubtiList:BG13160" /db_xref="UniProtKB/Swiss-Prot:O31629" /translation="MKYGIVLFPSKKLQDLANSYRKRYDPSYSLIPPHLTLRASFECA EEKADQLVSHLRNIAKESHPLVLKMTKYSSFAPVNNVIYIKAEPTEELKTLNEKLYTG VLAGEQEYNFVPHVTVGQNLSDDEHSDVLGQLKMQEVSHEEIVDRFHLLYQLENGSWT VYETFLLGRGE*" /label="yjcG CDS" gene complement(1175300..1175815) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /label="yjcG gene" CDS complement(1175852..1176574) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative stress-related hydrolase" /protein_id="NP_389068.1" /db_xref="EnsemblGenomes-Gn:BSU11860" /db_xref="EnsemblGenomes-Tr:CAB13043" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13161" /db_xref="UniProtKB/Swiss-Prot:O31630" /translation="MAPKNGTVQEKKFFSKELNEEMTLLVYLPSNYSPLYKYHVIIAQ DGHDYFRLGRIGRQVEELLSKREIDRSIIIGVPYKDVKERRNTYHPEGSKFSAYKRFI AHELVPFADDEYPTYQIGYGRTLIGDSLGATVSLMTALDYPNMFGNIIMQSPYVDKHV LEAVKQSDDIKHLSIYHQIGTKETDVHTTDGNILDFTEPNRELKQLLEKKLSDYDFEP FDGDHKWTYWQPLITPALKKML*" /label="yjcH CDS" gene complement(1175852..1176574) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /label="yjcH gene" misc_feature complement(1176613..1176632) /Source="Nicolas_upshift_promotors" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1176634) /Source="Nicolas_upshifts" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1176683..1176690 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1176705..1176724 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1176709 /Source="Nicolas_upshifts" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1176742..1176862 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswA RNA" gene 1176742..1176862 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /label="mswA gene" downshifts 1176867 /Source="Nicolas_upshifts" /id="D651" /incds=0 /nref=8 /ntot=59 /MaxReadThrough="7.71668" /MaxDrop="5.0477" /score="31.1477774" /energy="-15.2" /TU="U964" /idTUdmin="U962" /TUdmin=2024 /isTUend="FALSE" /label="downshifts" CDS 1176930..1178051 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /EC_number="2.5.1.49" /EC_number="2.5.1.48" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-synthase and O-acetylhomoserine thiolyase" /protein_id="NP_389069.1" /db_xref="EnsemblGenomes-Gn:BSU11870" /db_xref="EnsemblGenomes-Tr:CAB13044" /db_xref="GOA:O31631" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13162" /db_xref="UniProtKB/Swiss-Prot:O31631" /translation="MSQHVETKLAQIGNRSDEVTGTVSAPIYLSTAYRHRGIGESTGF DYVRTKNPTRQLVEDAIANLENGARGLAFSSGMAAIQTIMALFKSGDELIVSSDLYGG TYRLFENEWKKYGLTFHYDDFSDEDCLRSKITPNTKAVFVETPTNPLMQEADIEHIAR ITKEHGLLLIVDNTFYTPVLQRPLELGADIVIHSATKYLGGHNDLLAGLVVVKDERLG EEMFQHQNAIGAVLPPFDSWLLMRGMKTLSLRMRQHQANAQELAAFLEEQEEISDVLY PGKGGMLSFRLQKEEWVNPFLKALKTICFAESLGGVESFITYPATQTHMDIPEEIRIA NGVCNRLLRFSVGIEHAEDLKEDLKQALCQVKEGAVSFE*" /label="metI CDS" gene 1176930..1178051 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /label="metI gene" CDS 1178044..1179216 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /EC_number="4.4.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 11948165, 15760717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 11948165, 15760717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-lyase" /protein_id="NP_389070.1" /db_xref="EnsemblGenomes-Gn:BSU11880" /db_xref="EnsemblGenomes-Tr:CAB13045" /db_xref="GOA:O31632" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13163" /db_xref="UniProtKB/Swiss-Prot:O31632" /translation="MSKHNWTLETQLVHNPFKTDGGTGAVSVPIQHASTFHQSSFEEF GAYDYSRSGTPTRTALEETIAALEGGTRGFAFSSGMAAISTAFLLLSQGDHVLVTEDV YGGTFRMVTEVLTRFGIEHTFVDMTDRNEVARSIKPNTKVIYMETPSNPTLGITDIKA VVQLAKENGCLTFLDNTFMTPALQRPLDLGVDIVLHSATKFLSGHSDVLSGLAAVKDE ELGKQLYKLQNAFGAVLGVQDCWLVLRGLKTLQVRLEKASQTAQRLAEFFQKHPAVKR VYYPGLADHPGAETHKSQSTGAGAVLSFELESKEAVKKLVENVSLPVFAVSLGAVESI LSYPATMSHAAMPKEEREKRGITDGLLRLSVGVEHADDLEHDFEQALKEIAPVSVR*" /label="metC CDS" gene 1178044..1179216 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /label="metC gene" downshifts 1179199 /Source="Nicolas_upshifts" /id="D652" /incds=0 /nref=108 /ntot=205 /MaxReadThrough="4.73188" /MaxDrop="5.54268" /score="4.00424187" /energy="-9.2" /TU="U964" /idTUdmin="U964" /TUdmin="-1474" /isTUend="FALSE" /label="downshifts" misc_feature 1179233..1179251 /Source="Nicolas_upshift_promotors" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1179243 /Source="Nicolas_upshifts" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="upshifts" S_feature 1179244..1180773 /Source="Nicolas_S_feature" /locus_tag="new_1260806_1262335" /HighExp="MG 5, MG t5, MG 10, BMM, GM 25, MG 15, Glu, GM 15, GM 45, GM 10" /AntisenseName="yjcK" /AntisenseCor="0.123731990206979" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.671, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S428" CDS complement(1179249..1179794) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /EC_number="2.3.1.267" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2828880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal-protein-alanine N-acetyltransferase" /protein_id="NP_389071.1" /db_xref="EnsemblGenomes-Gn:BSU11890" /db_xref="EnsemblGenomes-Tr:CAB13046" /db_xref="GOA:O31633" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13164" /db_xref="UniProtKB/Swiss-Prot:O31633" /translation="MLKGKTIYVRPLEVTDAEENLGLQSENRDFFEQFSMIRADDYYT VEGQRKRITEYQERLEKDEEYHFGIFTASDDRLIGTVSLFQIIRGALQTAFIGYFLDK AHNGKGIMTEAVRLVVDYAFHELKLHRIEAGVMPRNLGSMRVLEKAGFHKEGIARKNV KINGVWEDHQVLAILNPDDEQ*" /label="yjcK CDS" gene complement(1179249..1179794) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /label="yjcK gene" downshifts complement(1179270) /Source="Nicolas_upshifts" /id="D653" /incds=0 /nref=14 /ntot=127 /MaxReadThrough="0.4032" /MaxDrop="4.23858" /score="-7.12102596" /energy="-7.3" /TU="NA" /idTUdmin="U966" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" CDS complement(1179864..1181054) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein; possibly aquaporin-related" /protein_id="NP_389072.1" /db_xref="EnsemblGenomes-Gn:BSU11900" /db_xref="EnsemblGenomes-Tr:CAB13047" /db_xref="GOA:O31634" /db_xref="InterPro:IPR008537" /db_xref="SubtiList:BG13165" /db_xref="UniProtKB/Swiss-Prot:O31634" /translation="MHSLISSDDVWVLWGFIAVWAAVSIGLEQRFKWASAVSGAIIAL AGAMVFTNVGVLPVESPVYDTVWSYVVPLAIPLLLFQINVRQIFKESRRLLFIFLISS VGTVLGSILAFFLLKQHIPYLDKIGGMISASYIGGGVNFAAMAAKFETPGEYVSATVV ADNFMMALLFFILISIPALKWFQRHYAMPFEEKVKADGNSGNSAESYWKRKDISLKDI AFNAGAAFALVAVSMKVSGYFKSIFSHPLLTGTLGDQYLVLTSLTVLIIFLFPRFFER LNGSQELGTFLIYLFFVVIGIPADLRLIVTNAPLILLFVFIIAISNLAVSLAAGKLFR VRLEEILLAVNATVGGPTTAAAMAIAKGWRELVAPIMLVGTLGYLIGNYVGTFMGNWF SSFL*" /label="yjcL CDS" gene complement(1179864..1181054) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /label="yjcL gene" promotor_-10 complement(1181080..1181099) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1181084) /Source="Nicolas_upshifts" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1181114..1181121) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1181148..1181155 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1181159 /Source="Nicolas_upshifts" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1181169..1181188 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-10" tRNA 1181227..1181299 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="valine tRNA (GAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Val2 tRNA" gene 1181227..1181299 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /label="trnSL-Val2 gene" promotor_-10 complement(1181241..1181258) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1181255) /Source="Nicolas_upshifts" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1181279..1181285) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1181289 /Source="Nicolas_upshifts" /id="D654" /incds=0 /nref=17 /ntot=80 /MaxReadThrough="4.64061" /MaxDrop="5.10012" /score="20.8247903" /energy="-9.1" /TU="U967" /idTUdmin="U965" /TUdmin=550 /isTUend="FALSE" /label="downshifts" S_feature complement(1181314..1182049) /Source="Nicolas_S_feature" /locus_tag="new_1262876_1263611_c" /HighExp="M9-stat, Lbstat, M0t90, Pyr, T0.30H, M40t90, C30, S1, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S429" S_feature 1181334..1182982 /Source="Nicolas_S_feature" /locus_tag="new_1262896_1264544" /HighExp="Cold, C30, G135, G180, G150, Oxctl, Fru, HPh, Glu, UNK1" /AntisenseName="yjcM" /AntisenseCor="0.46809452811910301" /AntisenseRegPval="-15.3" /CDS_PredictionProba="0.27514300000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S430" downshifts complement(1181343) /Source="Nicolas_upshifts" /id="D655" /incds=0 /nref=29 /ntot=192 /MaxReadThrough="1.23936" /MaxDrop="3.57085" /score="-4.98447688" /energy="-7.9" /TU="NA" /idTUdmin="U970" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1182051..1182139) /Source="Nicolas_S_feature" /locus_tag="new_1263613_1263701_c" /HighExp="aero, HPh, M0t45, SMM, dia0, GM 150, Mal, M/G, Mt0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S431" downshifts complement(1182094) /Source="Nicolas_upshifts" /id="D656" /incds=0 /nref=34 /ntot=148 /MaxReadThrough="4.13737" /MaxDrop="4.5557" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-751" /isTUend="FALSE" /label="downshifts" CDS complement(1182140..1183369) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20011599" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389073.1" /db_xref="EnsemblGenomes-Gn:BSU11910" /db_xref="EnsemblGenomes-Tr:CAB13048" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG13166" /db_xref="UniProtKB/Swiss-Prot:O31635" /translation="MKKELLASLVLCLSLSPLVSTNEVFAATTNKETKENVSITNEIG YEKVKDMLEQQKYDFEHNTPLAHPKESKLTDSDEGVLLYSALSKVDKQKFHEFTYDID DVKTSEKNNKLIVEAYITRNFVFGVEKVTTSLGDNIKLEIPKTTSNKQSSQSTNTSNL SFSQVKNSSNQLNVIPLSNSSKQLNVTQLNNSSSTLQYENDEEYSSDVKLDEFLKKYK QEVKNDDKEEVKSEDKPVSMNFNAANSNQLTVTATSVKGYSGYAAMKYAEKYALKPNK NYKYYKDKDCTNFVSQALRAGRMPYFKEWKPYTDAWVNAGAFRSYILKAGGIKMKTVS DTYSNVKLGDVYHYDYHNKIGLRYADGWMDHTAIVTSRANMKLYVSYHSTNRLNVPRE YVTSKEGGKRYVSSIRN*" /label="yjcM CDS" gene complement(1182140..1183369) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /label="yjcM gene" downshifts complement(1182262) /Source="Nicolas_upshifts" /id="D657" /incds=1 /nref=4 /ntot=143 /MaxReadThrough="5.58558" /MaxDrop="3.45178" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-919" /isTUend="FALSE" /label="downshifts" downshifts 1182939 /Source="Nicolas_upshifts" /id="D658" /incds=1 /nref=1 /ntot=48 /MaxReadThrough="3.19343" /MaxDrop="1.98614" /score="26.2462772" /energy="-24.7" /TU="NA" /idTUdmin="U967" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1183370..1183455) /Source="Nicolas_S_feature" /locus_tag="new_1264932_1265017_c" /HighExp="aero, SMM, T-3.40H, MG 150, Lbexp, SMMPr, GM 90, C90, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S432" promotor_-35 1183410..1183417 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1183432..1183451 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1183441..1183460) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1183445 /Source="Nicolas_upshifts" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1183459) /Source="Nicolas_upshifts" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1183473..1183479) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1183495..1183815 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389074.1" /db_xref="EnsemblGenomes-Gn:BSU11920" /db_xref="EnsemblGenomes-Tr:CAB13049" /db_xref="SubtiList:BG13167" /db_xref="UniProtKB/Swiss-Prot:O31636" /translation="MKKKTKIILSLLAALIVILIVLPVLSPVVFTASSEKGAIRHEIY KRGYPYQSYFAVLQKREGDNESGNLYYVNWLDWKDETGQTPHLCYSKKSSDGEYEVSC GTGP*" /label="yjcN CDS" gene 1183495..1183815 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /label="yjcN gene" downshifts 1183825 /Source="Nicolas_upshifts" /id="D659" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="3.73892" /MaxDrop="4.41989" /score="26.2462772" /energy="-24.7" /TU="U969" /idTUdmin="U967" /TUdmin=886 /isTUend="FALSE" /label="downshifts" S_feature 1183870..1183967 /Source="Nicolas_S_feature" /locus_tag="new_1265432_1265529" /HighExp="LoTm, B60, Cold, B36, T3.30H, T3.0H, T4.0H, T2.0H, Sw, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S433" CDS 1183968..1184099 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097707.1" /db_xref="EnsemblGenomes-Gn:BSU11928" /db_xref="EnsemblGenomes-Tr:CAX52597" /db_xref="UniProtKB/Swiss-Prot:C0H3Z0" /translation="MKQSKKKPSQKQHERLDRFWQQMMNTNMQTLRRGKGGAYKRRK* " /label="yjzF CDS" gene 1183968..1184099 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /label="yjzF gene" CDS 1184115..1184288 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097708.1" /db_xref="EnsemblGenomes-Gn:BSU11929" /db_xref="EnsemblGenomes-Tr:CAX52598" /db_xref="UniProtKB/Swiss-Prot:C0H3Z1" /translation="MMKNGFAYKNGKLVNIFCGKEELYNELKAFLVKTFSINVKEVSR PSIYRRTKSKQLE*" /label="yjzG CDS" gene 1184115..1184288 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /label="yjzG gene" CDS 1184325..1184786 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative DNA binding protein; phage island" /protein_id="NP_389075.1" /db_xref="EnsemblGenomes-Gn:BSU11930" /db_xref="EnsemblGenomes-Tr:CAB13050" /db_xref="GOA:O31637" /db_xref="InterPro:IPR013324" /db_xref="SubtiList:BG13168" /db_xref="UniProtKB/Swiss-Prot:O31637" /translation="MTDQMIAWEIEEWIRDYKFMLREIKRLNRVLNKVDFISTKLTAT YGEEAGMPRGSAGVSQAELRQMDRRERRLHKYESIVHYLDNAMEHIEEEKHRIVYDCM MEGMSYTAIANHLDCSRDTIRKIKTAIIGNIVNKVKEANFLQYLNSFKSAV*" /label="yjcO CDS" gene 1184325..1184786 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /label="yjcO gene" promotor_-35 1184757..1184764 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-35" promotor_-10 1184779..1184798 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-10" S_feature 1184787..1185027 /Source="Nicolas_S_feature" /locus_tag="new_1266349_1266589" /HighExp="LoTm, B60, Cold, B36, Diami, S8, dia15, C30, dia5, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.12525800000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S434" upshifts 1184787 /Source="Nicolas_upshifts" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="upshifts" promotor_-35 1185000..1185007 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1185021..1185039 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1185029 /Source="Nicolas_upshifts" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1185052..1185555 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein: phage island" /protein_id="NP_389076.1" /db_xref="EnsemblGenomes-Gn:BSU11940" /db_xref="EnsemblGenomes-Tr:CAB13051" /db_xref="GOA:O31638" /db_xref="SubtiList:BG13169" /db_xref="UniProtKB/Swiss-Prot:O31638" /translation="MKKQKNNKKKNIEKRNIEKRNIEEKNNEDLEELENAIYTYHKKE LLAFFLEKTRIGHDKEEYKRFQSLLYKLDIECLEFAISRFSHIDIIHDHSKYVPAFIP LFAAYLTMFFNFYEKHWGALSFAAGTIAAIVWIIAVERKHRNQAISIMKIFEQVKERK VKDRSKD*" /label="yjcP CDS" gene 1185052..1185555 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /label="yjcP gene" CDS 1185567..1185851 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389077.1" /db_xref="EnsemblGenomes-Gn:BSU11950" /db_xref="EnsemblGenomes-Tr:CAB13052" /db_xref="InterPro:IPR018597" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HGC" /db_xref="SubtiList:BG13170" /db_xref="UniProtKB/Swiss-Prot:O31639" /translation="MNKDKLRYAILKEIFEGNTPLSENDIGVTEDQFDDAVNFLKREG YIIGVHYSDDRPHLYKLGPELTEKGENYLKENGTWSKAYKTIKEIKDWIK*" /label="yjcQ CDS" gene 1185567..1185851 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /label="yjcQ gene" downshifts 1185821 /Source="Nicolas_upshifts" /id="D660" /incds=0 /nref=215 /ntot=271 /MaxReadThrough="1.63272" /MaxDrop="7.26386" /score="22.0381158" /energy="-7.2" /TU="NA" /idTUdmin="U969" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1185853) /Source="Nicolas_upshifts" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1185864..1185867) /Source="Nicolas_upshift_promotors" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1186012..1186539 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7489895, 7704261; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phage-related nucleic acid binding terminase small subunit; phage island" /protein_id="NP_389078.1" /db_xref="EnsemblGenomes-Gn:BSU11960" /db_xref="EnsemblGenomes-Tr:CAB13053" /db_xref="GOA:O31640" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010332" /db_xref="SubtiList:BG13171" /db_xref="UniProtKB/Swiss-Prot:O31640" /translation="MAEKHIQAYKDYVKGMKYKDLAEKYGVSVNTIKSWKQRHGWERK KGAPIEKSVHTKKGGQPGNKNALGNNGGAPQKNQNAVTHGFFSKFLPEETLEIMEEIQ ERSPADMIWDQIQIQYAAILRAQKIMFVSDKEEMIKELKKKRSLISEVSEIEDGLVIS FSTWFRYRLYSETNT*" /label="yjcR CDS" gene 1186012..1186539 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /label="yjcR gene" promotor_-35 1186686..1186691 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1186704..1186723 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1186707 /Source="Nicolas_upshifts" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="upshifts" CDS 1186713..1187030 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389079.1" /db_xref="EnsemblGenomes-Gn:BSU11970" /db_xref="EnsemblGenomes-Tr:CAB13054" /db_xref="GOA:O31641" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:1Q8B" /db_xref="SubtiList:BG13172" /db_xref="UniProtKB/Swiss-Prot:O31641" /translation="MKSHKMMGGGISMHYITACLKIISDKDLNEIMKEFKKLEEETNK EEGCITFHAYPLEPSERKIMLWEIWENEEAVKIHFTKKHTIDVQKQELTEVEWLMKSN VND*" /label="yjcS CDS" gene 1186713..1187030 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /label="yjcS gene" S_feature 1187031..1187266 /Source="Nicolas_S_feature" /locus_tag="new_1268593_1268828" /HighExp="dia5, H2O2, dia15, dia0, Lbexp, Lbtran, C90, Oxctl, S1, aero" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S435" CDS 1187267..1188022 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2243795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-carrier protein oxidoreductase; phage island" /protein_id="NP_389080.1" /db_xref="EnsemblGenomes-Gn:BSU11980" /db_xref="EnsemblGenomes-Tr:CAB13055" /db_xref="GOA:O31642" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13173" /db_xref="UniProtKB/Swiss-Prot:O31642" /translation="MSHSQEKIALITGASSQGDIGTAICRKLASQGIHIFFTHWNSDT AWIEEFQQEILRMGVRCEAMKIDLSDAHAAFTIHEKISDKLGYPSILINNAAHSASDN YVSLDAKSLDEHYAVNMRSNFLLCVEFARRFKKSNLISGRIINMTSGQDLGPLPGELA YAATKGAISAFTRSLSQELAPLGITVNAVNPGPTDSTWMTDEIRNFLSPKFPMGRIGT PDDAARMIAFLASDEAEWITGQIIHSEGGFIRG*" /label="yjdA CDS" gene 1187267..1188022 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /label="yjdA gene" S_feature 1188023..1188110 /Source="Nicolas_S_feature" /locus_tag="new_1269585_1269672" /HighExp="C90, S1, dia0, dia5, Mt0, Lbexp, Gly, H2O2, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S436" downshifts 1188067 /Source="Nicolas_upshifts" /id="D661" /incds=0 /nref=89 /ntot=238 /MaxReadThrough="2.66489" /MaxDrop="5.39812" /score="-0.84766737" /energy="-14.2" /TU="NA" /idTUdmin="U974" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(1188110..1188170) /Source="Nicolas_S_feature" /locus_tag="new_1269672_1269732_c" /HighExp="Lbstat, BI, BT, nit, S2, ferm, B60, B36, M0t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S437" downshifts complement(1188141) /Source="Nicolas_upshifts" /id="D662" /incds=0 /nref=80 /ntot=134 /MaxReadThrough="1.9707" /MaxDrop="7.43843" /score="-5.56180712" /energy="-14.2" /TU="NA" /idTUdmin="U975" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1188171..1188518) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported protein; phage island" /protein_id="NP_389081.1" /db_xref="EnsemblGenomes-Gn:BSU11990" /db_xref="EnsemblGenomes-Tr:CAB13056" /db_xref="InterPro:IPR003343" /db_xref="InterPro:IPR008964" /db_xref="SubtiList:BG13174" /db_xref="UniProtKB/Swiss-Prot:O31643" /translation="MNFKKTVVSALSISALALSVSGVASAHEINSTPTEVKNISISPT HVIKIQDYNLPLKVGETYSVKNNSATRYWTDNQKVAEVDQNGLVTAKSKGKATITLFK GTAVFGKVYVTVY*" /label="yjdB CDS" gene complement(1188171..1188518) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /label="yjdB gene" promotor_-10 complement(1188550..1188568) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1188563) /Source="Nicolas_upshifts" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1188565..1189021) /Source="Nicolas_S_feature" /locus_tag="new_1270127_1270583_c" /HighExp="T1.30H, T2.0H, T2.30H, T3.0H, M9-stat, T1.0H, Lbstat, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S438" promotor_-35 complement(1188579..1188587) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1188981..1188999 /Source="Nicolas_upshift_promotors" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1188993 /Source="Nicolas_upshifts" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="upshifts" promotor_-10 complement(1188999..1189018) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1189021) /Source="Nicolas_upshifts" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1189032..1189039) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1189069..1191015 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10438772, 10960106, 23551403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438772, 10960106, 23551403; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional DNA-binding activator" /protein_id="NP_389082.2" /db_xref="EnsemblGenomes-Gn:BSU12000" /db_xref="EnsemblGenomes-Tr:CAB13057" /db_xref="GOA:O31644" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG13175" /db_xref="UniProtKB/Swiss-Prot:O31644" /translation="MEYINTRQKEILYLLLSEPDDYLVVQDFADRVQCSEKTIRNDLK VIEDYLNEHSHAQLIRKPGLGVYLHIEEQERTWLSQQLHTEHFSSRQRSDKERMLHIA YDLLMNPKPVSAKDIAARHFVNRSSIKKDLYAVEEWLKRFDLTLVSRQRLGLKVEGNE RNKRKALARISDLIHNTAFTSQFIKSKFLHYEVDFVTKEIKSLQKKHSLYFTDETFES LLLHTLLMVRRIKMKQPISLSPKEMAAVKKKKEYQWTFACLQRLEPVFAIRFPEEEAV YLTLHILGGKVRYPLQTEENLENAVLPKVVGHLINRVSELKMMDFHKDQDLINGLNIH LNTVLQRLSYDLSVANPMLNDIKKMYPYLFHLIIDVLEDINQTFDLHIPEEEAAYLTL HFQAAIERMQGSSETHKKAVIVCHMGIGMSQLLRTKIERKYHQIAVMACIAKADLKDY IKKHEDIDLVISTIALENITVPHIVVSPLLEPGEEKKLSAFIRQLGESHRQKQKTFQM LNNTTPFLVFLQQEAEHRYKLIEQLATALFEKGYVDKDYAVHAVMREKMSATNIGSGI AIPHANAKFIKQSAIAIATLKEPLEWGNEKVSLVFMLAVKHEDQTMTKQLFSELSYLS EQPAFVQKLTKETNVMTFLSHLDY*" /label="manR CDS" gene 1189069..1191015 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /label="manR gene" downshifts 1190991 /Source="Nicolas_upshifts" /id="D663" /incds=0 /nref=3 /ntot=35 /MaxReadThrough="4.64475" /MaxDrop="3.79938" /score="28.4199725" /energy="-9.1" /TU="U976" /idTUdmin="U976" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" SCAR 1191045..1191046 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs02" S_feature <1191046..1191144 /Source="Nicolas_S_feature" /locus_tag="new_1275640_1275738" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, H2O2, dia5, Fru, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15168699999999999" /TUshortSig="SigA" /TUshortPSig="0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S439" promotor_-35 1191119..1191125 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1191140..1191159 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1191146..1191214 /Source="Nicolas_S_feature" /locus_tag="new_1275740_1275808" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, dia5, Fru, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S440" upshifts 1191146 /Source="Nicolas_upshifts" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="upshifts" CDS 1191215..1191697 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20139185" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389085.1" /db_xref="EnsemblGenomes-Gn:BSU12030" /db_xref="EnsemblGenomes-Tr:CAB13060" /db_xref="InterPro:IPR016787" /db_xref="SubtiList:BG13178" /db_xref="UniProtKB/Swiss-Prot:O31647" /translation="MSVTFPSSGCPSFFNIFYEEGIVMKLTIYYDGQFWVGVVEVVDN GKLRAFRHLFGKEPRDSEVLEFVHNQLLNMMAQAEQEGVRLQGRRQKKINPKRLQRQV SKELKNAGVTSKAQEAIKLELEARKQKKKQIMKEQREHVKEQRYMLKKQKAKKKHRGK *" /label="yjdF CDS" gene 1191215..1191697 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /label="yjdF gene" downshifts 1191677 /Source="Nicolas_upshifts" /id="D664" /incds=0 /nref=220 /ntot=267 /MaxReadThrough="5.32805" /MaxDrop="7.35641" /score="7.68574519" /energy="-10.2" /TU="U978" /idTUdmin="U980" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1191743..1192249) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389086.1" /db_xref="EnsemblGenomes-Gn:BSU12040" /db_xref="EnsemblGenomes-Tr:CAB13061" /db_xref="GOA:O31648" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13179" /db_xref="UniProtKB/Swiss-Prot:O31648" /translation="MVLLETNRLRLQTIDIPLLDAASKQDHQAIKELGYETNGEWPNS DFFEAIPYFREILVKNNGTKGFDSWIIVKKDNYEIVGGTGFLGDPDENGMIEIGFATN KSHRRKGYCVEAAQKLINWALSRETVSRITARCEHDNLGSQKTLEKLGFILNHKSAEY KHWIYVTK*" /label="yjdG CDS" gene complement(1191743..1192249) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /label="yjdG gene" downshifts complement(1191767) /Source="Nicolas_upshifts" /id="D665" /incds=0 /nref=13 /ntot=154 /MaxReadThrough="2.51872" /MaxDrop="4.09551" /score="15.8830125" /energy="-9.9" /TU="NA" /idTUdmin="U984" /TUdmin=7 /isTUend="TRUE" /label="downshifts" misc_feature complement(1192274..1192293) /Source="Nicolas_upshift_promotors" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1192280) /Source="Nicolas_upshifts" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1192282..1192467) /Source="Nicolas_S_feature" /locus_tag="new_1276876_1277061_c" /HighExp="S5, S4, S7, S6, S8, B36, LoTm, S3, B60, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.289238" /TUshortSig="SigEF, SigWXY" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S441" CDS complement(1192468..1192863) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389087.2" /db_xref="EnsemblGenomes-Gn:BSU12050" /db_xref="EnsemblGenomes-Tr:CAB13062" /db_xref="SubtiList:BG13180" /db_xref="UniProtKB/Swiss-Prot:O31649" /translation="MYHYFYGPALIPYFSHTHNPQRSPDFSERQRRREITLTVDGFVP PSSTEDLGDGFYSYAWTNQQVINPGEYLVCHLEGRDINVINGGFTPRDTAPLYAVASF PRRRNQWVIIIHNPVQTQRAISLYLIAKR*" /label="yjdH CDS" gene complement(1192468..1192863) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /label="yjdH gene" promotor_-10 complement(1192886..1192904) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1192899) /Source="Nicolas_upshifts" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1192901..1193601) /Source="Nicolas_S_feature" /locus_tag="new_1277495_1278195_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, S0, T2.0H, Salt, T2.30H, T-1.10H" /AntisenseName="yjdI" /AntisenseCor="-0.383915151906285" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S442" promotor_-35 complement(1192919..1192924) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1193007..1193014 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1193028..1193047 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1193039 /Source="Nicolas_upshifts" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="upshifts" CDS 1193092..1193571 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22128149; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cys-tRNApro deacetylase; tRNA editing" /protein_id="NP_389088.1" /db_xref="EnsemblGenomes-Gn:BSU12060" /db_xref="EnsemblGenomes-Tr:CAB13063" /db_xref="GOA:O31650" /db_xref="InterPro:IPR004369" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG13181" /db_xref="UniProtKB/Swiss-Prot:O31650" /translation="MAKKMAKTNAVRLIEQQNISYEVLGYKTDGQPVDGISVAEKIGY SLKYVYKTLVAAAGTNHYYVFVVPVAEELDVKKAAKVTGEKKIEMIAMKELLAVTGYL RGGCSPIGMKKLFPTYIDASAETLDFIIVSAGKIGMQLKLAPQDLARSCDAAFAEIV* " /label="trnE CDS" gene 1193092..1193571 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /label="trnE gene" downshifts 1193570 /Source="Nicolas_upshifts" /id="D666" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="2.68858" /MaxDrop="3.19616" /score="-5.52314972" /energy="-12.5" /TU="NA" /idTUdmin="U978" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1193611..1193805) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097709.1" /db_xref="EnsemblGenomes-Gn:BSU12069" /db_xref="EnsemblGenomes-Tr:CAX52599" /db_xref="InterPro:IPR025234" /db_xref="UniProtKB/Swiss-Prot:C0H3Z2" /translation="MKEYEFVRVELSTMRRRPKEDYQQIIHDYAKRGWRFVQIFAPSI DGYGAAAYFEIIFERDAEKA*" /label="yjzH CDS" gene complement(1193611..1193805) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /label="yjzH gene" downshifts complement(1193646) /Source="Nicolas_upshifts" /id="D667" /incds=0 /nref=6 /ntot=144 /MaxReadThrough="7.83072" /MaxDrop="2.95935" /score="-6.07514027" /energy="-7" /TU="U984" /idTUdmin="U987" /TUdmin=220 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1193819..1193834) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1193835) /Source="Nicolas_upshifts" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1193846..1193855) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1193971..1194300) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389089.1" /db_xref="EnsemblGenomes-Gn:BSU12070" /db_xref="EnsemblGenomes-Tr:CAB13064" /db_xref="GOA:O31651" /db_xref="InterPro:IPR016508" /db_xref="InterPro:IPR025440" /db_xref="SubtiList:BG13182" /db_xref="UniProtKB/Swiss-Prot:O31651" /translation="MKGIFLVVQLGFSIMVFLFLAAVNWYQGSELVSDRFDWNYTAKL SKLLNGIDAVSSPKQISQLDFFIYSAKHYPVMSALMIISFLYVLAALFLLIYSVKCNK QEIHLDC*" /label="yjdJ CDS" gene complement(1193971..1194300) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /label="yjdJ gene" promotor_-10 complement(1194337..1194356) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1194350) /Source="Nicolas_upshifts" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1194352..1194919) /Source="Nicolas_S_feature" /locus_tag="new_1278946_1279513_c" /HighExp="S8, S6, nit, S7, ferm, S2, S5, M9-tran, M/G, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S443" promotor_-35 complement(1194371..1194376) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1194404..1194408 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1194424..1194443 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1194428..1194929 /Source="Nicolas_S_feature" /locus_tag="new_1279022_1279523" /HighExp="LBGstat, C30, HPh, Oxctl, dia15, Paraq, T0.30H, C90, LBGtran, LPh" /AntisenseName="ctaO" /AntisenseCor="-0.43946575370083102" /AntisenseRegPval="-13.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S444" upshifts 1194428 /Source="Nicolas_upshifts" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1194920..1195909) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10675592, 15491161, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10675592, 15491161, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor protoheme IX farnesyltransferase 1 (heme Osynthase)" /protein_id="NP_389090.2" /db_xref="EnsemblGenomes-Gn:BSU12080" /db_xref="EnsemblGenomes-Tr:CAB13065" /db_xref="GOA:O31652" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG13183" /db_xref="UniProtKB/Swiss-Prot:O31652" /translation="MQFWGRRLFLENTRDSAAISETKYIKASNRVTIYDFIKLAKPGI IISNSIAAFGGFWIAFASAEKTLTGLAFLMTMVTAMLGTAFVMASGTVYNNYFDRHMD AKMARTRSRASVTGKMPPAMILTYGSVLGIAGLAMLYSLNPLTAFLGLAAFIFYAIIY TVWVKRTSVWSTFVGSFPGAAPPLMGYCAVTGDFSMTAVLLYTIMFLWQPPHFWAIGI RRKEEYRAAGVPLLPVVKGNHVTKIKMMQYIAVLVPVTLLFPFSLGTGHISPFYFLAA LVLGGIWIKKSIKGFKTDDDVKWAKDMFVYSLIYFCLLFFIMMIDSFMMFLIR*" /label="ctaO CDS" gene complement(1194920..1195909) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /label="ctaO gene" promotor_-10 complement(1195910..1195929) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-10" upshifts complement(1195913) /Source="Nicolas_upshifts" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="upshifts" promotor_-35 complement(1195943..1195948) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-35" CDS complement(1196032..1196280) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1391045, 1917883, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1391045, 1917883, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner coat)" /protein_id="NP_389091.2" /db_xref="EnsemblGenomes-Gn:BSU12090" /db_xref="EnsemblGenomes-Tr:CAB13066" /db_xref="GOA:P11863" /db_xref="SubtiList:BG10495" /db_xref="UniProtKB/Swiss-Prot:P11863" /translation="MDYPLNEQSFEQITPYDERQPYYYPRPRPPFYPPYYYPRPYYPF YPFYPRPPYYYPRPRPPYYPWYGYGGGYGGGYGGGYGY*" /label="cotT CDS" gene complement(1196032..1196280) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /label="cotT gene" downshifts complement(1196042) /Source="Nicolas_upshifts" /id="D668" /incds=0 /nref=37 /ntot=82 /MaxReadThrough="5.73194" /MaxDrop="6.23577" /score="25.0951218" /energy="-8.4" /TU="U989" /idTUdmin="U990" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 1196276..1196280 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1196289..1196303 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1196298 /Source="Nicolas_upshifts" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1196305..1196324) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1196314) /Source="Nicolas_upshifts" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1196338..1196347) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1196395..1196402 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1196409..1196428) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1196416..1196435 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1196418) /Source="Nicolas_upshifts" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="upshifts" upshifts 1196429 /Source="Nicolas_upshifts" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1196430..1196533 /Source="Nicolas_S_feature" /locus_tag="new_1281024_1281127" /HighExp="Heat, T0.30H, T1.0H, ferm, Diami, dia5, T1.30H, M9-stat, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S445" promotor_-35 complement(1196442..1196449) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1196534..1197937 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 17878218, 22277649" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 17878218, 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid deacetylase" /protein_id="NP_389092.1" /db_xref="EnsemblGenomes-Gn:BSU12100" /db_xref="EnsemblGenomes-Tr:CAB13067" /db_xref="GOA:O34798" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR017219" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="SubtiList:BG13184" /db_xref="UniProtKB/Swiss-Prot:O34798" /translation="MLAKRIKWFHVLIAVVCVVGLIGFFHNHSLKKETVMNKVRTDSQ YGNVEIATLVNDGKTFNYAVNYPVFKNEKMDSALKRFAEKEVRQFQKETKDVDQEHTT KRNELNVDYKIVHYAKQTVAIVFNEYKYIGGAHGQTVKKTFNYDFSKQAFLSIDDIFK EDADYLHKLSLIAYHELKKNKDIAADDALLKEGTAPKKENFSRFAIKEDYIELYFDTY QVAAGYLGEQSIAIKKSLLKDILKEQYIDKAKNKNKIKEQKPKHEVISLPKEETVDPN QKVIALTFDDGPNPATTNQILDSLKKYKGHATFFVLGSRVQYYPETLIRMLKEGNEVG NHSWSHPLLTRLSVKEALKQINDTQDIIEKISGYRPTLVRPPYGGINDELRSQMKMDV ALWDVDPEDWKDRNKKTIVDRVMNQAGDGRTILIHDIYRTSADAADEIIKKLTDQGYQ LVTVSQLEEVKKQREAK*" /label="pdaC CDS" gene 1196534..1197937 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /label="pdaC gene" downshifts 1197926 /Source="Nicolas_upshifts" /id="D669" /incds=0 /nref=173 /ntot=238 /MaxReadThrough="1.38483" /MaxDrop="6.60322" /score="39.935002" /energy="-13.8" /TU="NA" /idTUdmin="U991" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1197977..1198450) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389093.1" /db_xref="EnsemblGenomes-Gn:BSU12110" /db_xref="EnsemblGenomes-Tr:CAB13068" /db_xref="InterPro:IPR021224" /db_xref="SubtiList:BG13185" /db_xref="UniProtKB/Swiss-Prot:O34554" /translation="MKRLFMKASLVLFAVVFVFAVKGAPAKAETHAYDGKSPYYNDCA SSGSTKKSSNLVNASNQVIGVVELKFSSTCKTAWAKITMNNTLTSGYEANAEITRNTD GKRYNCDSAGGNGKAVAGQKSCYTPMVYDLDPRTSYAFGKYSGPNLNVWATTGSY*" /label="yjfA CDS" gene complement(1197977..1198450) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /label="yjfA gene" downshifts complement(1197981) /Source="Nicolas_upshifts" /id="D670" /incds=0 /nref=33 /ntot=176 /MaxReadThrough="2.25434" /MaxDrop="5.38548" /score="20.5383759" /energy="-13.8" /TU="NA" /idTUdmin="U992" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1198472..1198490) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1198490) /Source="Nicolas_upshifts" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1198505..1198510) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1198575..1198742) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389094.1" /db_xref="EnsemblGenomes-Gn:BSU12120" /db_xref="EnsemblGenomes-Tr:CAB13069" /db_xref="InterPro:IPR025906" /db_xref="SubtiList:BG13186" /db_xref="UniProtKB/Swiss-Prot:O34438" /translation="MDIPALSVAMHQASLAQNVNIALTKKRLDTAQQNADQTLKMIQH PTLGQTIDVKA*" /label="yjfB CDS" gene complement(1198575..1198742) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /label="yjfB gene" downshifts complement(1198578) /Source="Nicolas_upshifts" /id="D671" /incds=0 /nref=109 /ntot=232 /MaxReadThrough="3.53249" /MaxDrop="4.93218" /score="-9.08395816" /energy="-13.9" /TU="U993" /idTUdmin="U993" /TUdmin="-576" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1198754..1198772) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1198763) /Source="Nicolas_upshifts" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1198785..1198792) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1198869..1199768 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389095.2" /db_xref="EnsemblGenomes-Gn:BSU12130" /db_xref="EnsemblGenomes-Tr:CAB13070" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13187" /db_xref="UniProtKB/Swiss-Prot:O34458" /translation="MNLVMEKTFEQYEKLFSMEEQKREDVFRYTMMRPFEKMWTAIQV PLKAKEPNGYDVIMAAKMLGYLDVRDAESGQKALQILKESHVSETAESALRQCIFFAE REQLRVNAKEIKFGLYIADPNKLQLQKGYCGFGGIPGFIHVWINPNSYNLPRIPSIIA HEFHHNVRFSYIDFHHGSVSVGDYLVIEGLAESFARELFGTERLGPWVTRFDHEDLQY SIDVINEVLDVKGFSEVSRYMFGDPIANDQGFKPAGLSAFAGYAVGYHAVQSFMNQHH ITISEATRLDAKTIISQCGLFST*" /label="yjfC CDS" gene 1198869..1199768 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /label="yjfC gene" CDS complement(1199777..1200175) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_389096.1" /db_xref="EnsemblGenomes-Gn:BSU12140" /db_xref="EnsemblGenomes-Tr:CAB13071" /db_xref="GOA:O35027" /db_xref="InterPro:IPR021257" /db_xref="SubtiList:BG13188" /db_xref="UniProtKB/Swiss-Prot:O35027" /translation="MKRNRWIYAVFTILIIGLGLGSRAFSSVLPDTLNTYLGDSLWAA MIFTGCGFLFRKLKTMITGIISLSFCFVIEFSQLYHAEWIDQIRDTSLGGLVLGYGFL WSDIEAYTIGIAACAAIELLVLGIKKRRCM*" /label="yjgA CDS" gene complement(1199777..1200175) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /label="yjgA gene" downshifts complement(1199807) /Source="Nicolas_upshifts" /id="D672" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.86089" /MaxDrop="2.52307" /score="23.8106216" /energy="-10.1" /TU="U994,U995" /idTUdmin="U995" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1200204..1200223) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1200223) /Source="Nicolas_upshifts" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1200238..1200245) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1200276..1200851) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1580552" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389097.1" /db_xref="EnsemblGenomes-Gn:BSU12150" /db_xref="EnsemblGenomes-Tr:CAB13072" /db_xref="InterPro:IPR025453" /db_xref="PDB:4YGT" /db_xref="SubtiList:BG13189" /db_xref="UniProtKB/Swiss-Prot:O34960" /translation="MKKTMSAITAAAAVTSCFTGFGAASFSAPAKAAAQTNTLSENTN QSAAELVKNLYNTAYKGEMPQQAQGLTINKSTKGDVHAAFGEPERPVGGDNRFDLYHW NMGQPGYGFSYHKDMTISEIRYFGTGVERQLNLGGVTPEVLQKQLGPVNRVLTVPFTD EIDYVYDTGRYELHFVIGTDQTADHVNLKAK*" /label="yjgB CDS" gene complement(1200276..1200851) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /label="yjgB gene" downshifts complement(1200291) /Source="Nicolas_upshifts" /id="D673" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.38565" /MaxDrop="3.9021" /score="23.8106216" /energy="-10.1" /TU="U995" /idTUdmin="U995" /TUdmin="-727" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1200870..1200888) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1200885) /Source="Nicolas_upshifts" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1200902..1200908) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1200926..1200932 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1200947..1200965 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1200948 /Source="Nicolas_upshifts" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="upshifts" CDS 1200997..1203954 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /EC_number="1.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdoenzyme; putative formate dehydrogenase" /protein_id="NP_389098.1" /db_xref="EnsemblGenomes-Gn:BSU12160" /db_xref="EnsemblGenomes-Tr:CAB13073" /db_xref="GOA:O34720" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG13190" /db_xref="UniProtKB/Swiss-Prot:O34720" /translation="MAGKKTITINGVEMEASEEQTVLQLLNNSSIEVPQVCYHPSLGP IETCDTCIVSINGELKRSCSAELKDGDVIDTLSPDVKKAQVIGMDKILYNHELYCTVC DYNNGGCEIHNTVKEMKINHQSIPFDHKPYHKDESHPFYRYDPDQCILCGRCVEACQD VQVTETLTIDWERKRPRVIWDNDVPINESSCVSCGHCSTVCPCNAMMEKGMEGEAGYL TGINNETLRPMIEITKGVETGYGSILAISDMESAMRDERIKKTKTVCTYCGVGCSFDV WTKGRDILKVEPQEEAPANGISTCVKGKFGWDFVNSEERLTKPLIREGDHFREAEWEE ALLLIASKFTELKEAFGPDSLAFITSSKCTNEESYLMQKLARGVIGTNNVDNCSRYCQ SPATAGLFRTVGYGGDSGSITDIAQADLVLIIGSNTSESHPVLSTRIKRAHKLRGQKV IVADIRKHEMAERSDLFVQPRAGSDIVWLNAIAKYLIENGKADERFLRERVNGRDEYV KSLAPYTLEYAEEKTGIDQETLIQMAEMIGQADSVCALWAMGVTQHIGGSDTSTAISN LLLVTGNYGKPGAGSYPLRGHNNVQGASDFGSMPDRLPGYEKVTDEQVRQKYERVWGV PLPKEPGMTNHEMIEKIHSGQLKAMYVKGEEMGLVDSNINHVHAAYEKLDFFVVQDIF LSRTAEFADVVLPASPSLEKEGTFTNTERRIQRLYQVFEPLGESKPDWQIIMEVANKL GAGWLYEHPADIMEEAAKLSPIYAGVTYERLEGYNSLQWPVNADGKDSPLLFTERFPF PDGKAILYPVQWTEPKEFGEEYDIHVNNGRLLEHFHEGNLTYKSKGISEKTPEVFLEI SPELAAERGIQDGTLVRLTSPFGNVKVKCLITDRVKGKEVYLPMNDSGEAAINLLTGS HADKDTDTPAYKETSAKMEILKHDGISPLPKINHRNGNPQPQIGVQVHKKWARKDYIF PGDAVKRGMGHNG*" /label="yjgC CDS" gene 1200997..1203954 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /label="yjgC gene" CDS 1203947..1204507 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389099.1" /db_xref="EnsemblGenomes-Gn:BSU12170" /db_xref="EnsemblGenomes-Tr:CAB13074" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13191" /db_xref="UniProtKB/Swiss-Prot:O34681" /translation="MAKAIKRIQKIEVTEEDQRKRDLREIEDALIDHKEAILETLHML GHMNERGVLPLLRGLFGQGDKVLDILVKKADTEETANTLKNLLLLFGTLGMLDVKQLE PLILKVNAGVASAVEQKNSEEKTGYFDIIRSLKDPEINKSITLLFSFLKGMGQDTKEL ERTTQPPEHQKHHQEPREKRGMNKRD*" /label="yjgD CDS" gene 1203947..1204507 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /label="yjgD gene" downshifts 1204500 /Source="Nicolas_upshifts" /id="D674" /incds=0 /nref=18 /ntot=84 /MaxReadThrough="5.25706" /MaxDrop="6.46184" /score="20.7921843" /energy="-15" /TU="U996" /idTUdmin="U996" /TUdmin="-819" /isTUend="FALSE" /label="downshifts" S_feature 1204545..1204663 /Source="Nicolas_S_feature" /locus_tag="new_1289139_1289257" /HighExp="Etha, Salt, Heat, S8, M9-stat, S7, LPhT, G135, C30, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S446" promotor_-35 1204641..1204644 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1204660..1204679 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1204665 /Source="Nicolas_upshifts" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="upshifts" CDS 1204704..1205345 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389100.1" /db_xref="EnsemblGenomes-Gn:BSU12180" /db_xref="EnsemblGenomes-Tr:CAB13075" /db_xref="GOA:O34725" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="PDB:3CFU" /db_xref="SubtiList:BG13192" /db_xref="UniProtKB/Swiss-Prot:O34725" /translation="MKKVLLLLFVLTIGLALSACSQSSDASEKEKPKEKKSQEELEKE LDKELKKGGEPKTKKDDQIHKIGETFKAGHTNFTVNKVDRVQKGEYMNVGGAVNEETK TIKDDEERLIIEVTMENIGEDSISYNFIGFDLRDKNDQSVRPVFSIEEKGRILMGGTL VSGKKVTGVLSYVIPKGEQKHYTLVYNPFLADTNSSNTEERVKDDIDYLVKLD*" /label="yjhA CDS" gene 1204704..1205345 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /label="yjhA gene" downshifts complement(1204713) /Source="Nicolas_upshifts" /id="D675" /incds=0 /nref=7 /ntot=57 /MaxReadThrough="2.5769" /MaxDrop="3.81596" /score="-9.34186213" /energy="-3" /TU="NA" /idTUdmin="U998" /TUdmin=1386 /isTUend="FALSE" /label="downshifts" downshifts 1205318 /Source="Nicolas_upshifts" /id="D676" /incds=0 /nref=24 /ntot=186 /MaxReadThrough="4.29897" /MaxDrop="3.4683" /score="19.6571267" /energy="-17" /TU="U997" /idTUdmin="U996" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS 1205424..1206050 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /EC_number="3.6.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12483591, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ADP-ribose pyrophosphatase" /protein_id="NP_389101.2" /db_xref="EnsemblGenomes-Gn:BSU12190" /db_xref="EnsemblGenomes-Tr:CAB13076" /db_xref="GOA:C0SPC3" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG13193" /db_xref="UniProtKB/Swiss-Prot:C0SPC3" /translation="MIKVQTKWLERAQRIRAIAQAGLAFSKDVYDRERYEELMKLSAE MMADYSEKDIEVITDLWQGEKGYPTPKADVRGAVFRENQILLVREKHDELWSLPGGFC EIGLSPAENVVKEIKEESGYDTEPSRLLAVLDSHKHSHPPQPYHYYKIFIACSMTDGQ GETGIETNHAAFFPEDRLPPLSPKRNTPSQLSMLFDFLRHPDKKTIFD*" /label="yjhB CDS" gene 1205424..1206050 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /label="yjhB gene" downshifts 1206052 /Source="Nicolas_upshifts" /id="D677" /incds=0 /nref=97 /ntot=202 /MaxReadThrough="0.597580000000001" /MaxDrop="6.62023" /score="12.2319602" /energy="-7" /TU="NA" /idTUdmin="U997" /TUdmin=7 /isTUend="TRUE" /label="downshifts" downshifts complement(1206055) /Source="Nicolas_upshifts" /id="D678" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.18907" /MaxDrop="3.31161" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(1206081..1206359) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 14563871" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389102.1" /db_xref="EnsemblGenomes-Gn:BSU12200" /db_xref="EnsemblGenomes-Tr:CAB13077" /db_xref="SubtiList:BG13194" /db_xref="UniProtKB/Swiss-Prot:O34679" /translation="MAAQTDYKKQVVGILLSLAFVLFVFSFSERHEKPLVEGKKQENW HTVVDKASVKIYGSRLVEENKLKQKLGHKQADSILTLLKLANEKHITL*" /label="yjiA CDS" gene complement(1206081..1206359) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /label="yjiA gene" downshifts complement(1206099) /Source="Nicolas_upshifts" /id="D679" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="1.96302" /MaxDrop="5.98058" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1206388..1206399) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1206401..1206407) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1206407) /Source="Nicolas_upshifts" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1206409..1206825) /Source="Nicolas_S_feature" /locus_tag="new_1291003_1291419_c" /HighExp="S6, S7, S8, S5, BT, C30, Pyr, G/S, C90, B36" /AntisenseName="yjiB" /AntisenseCor="-0.25565388711625397" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S447" upshifts 1206577 /Source="Nicolas_upshifts" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1206578..1206597 /Source="Nicolas_upshift_promotors" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1206595..1206749 /Source="Nicolas_S_feature" /locus_tag="new_1291189_1291343" /HighExp="BC, T5.0H, T4.0H, C90, Sw, T3.30H, Lbstat, Diami, dia5, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.995811" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S448" CDS 1206750..1207940 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25587700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25587700; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP109B1, monooxygenase" /protein_id="NP_389103.1" /db_xref="EnsemblGenomes-Gn:BSU12210" /db_xref="EnsemblGenomes-Tr:CAB13078" /db_xref="GOA:O34374" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:4RM4" /db_xref="SubtiList:BG13195" /db_xref="UniProtKB/Swiss-Prot:O34374" /translation="MNVLNRRQALQRALLNGKNKQDAYHPFPWYESMRKDAPVSFDEE NQVWSVFLYDDVKKVVGDKELFSSCMPQQTSSIGNSIINMDPPKHTKIRSVVNKAFTP RVMKQWEPRIQEITDELIQKFQGRSEFDLVHDFSYPLPVIVISELLGVPSAHMEQFKA WSDLLVSTPKDKSEEAEKAFLEERDKCEEELAAFFAGIIEEKRNKPEQDIISILVEAE ETGEKLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELRSHPELMPQAV EEALRFRAPAPVLRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRR HPNPHIAFGHGIHFCLGAPLARLEANIALTSLISAFPHMECVSITPIENSVIYGLKSF RVKM*" /label="cypE CDS" gene 1206750..1207940 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /label="cypE gene" promotor_-10 complement(1206823..1206842) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1206825) /Source="Nicolas_upshifts" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1206856..1206865) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1207963..1209141 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 24893262, 27444326; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyphenols TDP-rhamnosyltransferase, promiscuous" /protein_id="NP_389104.1" /db_xref="EnsemblGenomes-Gn:BSU12220" /db_xref="EnsemblGenomes-Tr:CAB13079" /db_xref="GOA:O34539" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG13196" /db_xref="UniProtKB/Swiss-Prot:O34539" /translation="MKKYHISMINIPAYGHVNPTLALVEKLCEKGHRVTYATTEEFAP AVQQAGGEALIYHTSLNIDPKQIREMMEKNDAPLSLLKESLSILPQLEELYKDDQPDL IIYDFVALAGKLFAEKLNVPVIKLCSSYAQNESFQLGNEDMLKKIREAEAEFKAYLEQ EKLPAVSFEQLAVPEALNIVFMPKSFQIQHETFDDRFCFVGPSLGERKEKESLLIDKD DRPLMLISLGTAFNAWPEFYKMCIKAFRDSSWQVIMSVGKTIDPESLEDIPANFTIRQ SVPQLEVLEKADLFISHGGMNSTMEAMNAGVPLVVIPQMYEQELTANRVDELGLGVYL PKEEVTVSSLQEAVQAVSSDQELLSRVKNMQKDVKEAGGAERAAAEIEAFMKKSAVPQ *" /label="ppuG CDS" gene 1207963..1209141 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /label="ppuG gene" CDS complement(1209182..1209370) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="YP_003097710.1" /db_xref="EnsemblGenomes-Gn:BSU12229" /db_xref="EnsemblGenomes-Tr:CAX52600" /db_xref="UniProtKB/Swiss-Prot:C0H3Z3" /translation="METKKEEYETKGYDTSIVYEFNEYPDARSGRCDNCDYTLFKSSV KGGKFLRECRRCGMKKNI*" /label="yjzI CDS" gene complement(1209182..1209370) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /label="yjzI gene" downshifts complement(1209198) /Source="Nicolas_upshifts" /id="D680" /incds=0 /nref=94 /ntot=231 /MaxReadThrough="-0.1433" /MaxDrop="5.1712" /score="13.0160925" /energy="-9.5" /TU="NA" /idTUdmin="U1001" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1209396..1209415) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1209399) /Source="Nicolas_upshifts" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1209429..1209435) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1209457..1209464 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1209479..1209498 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1209490 /Source="Nicolas_upshifts" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1209505..1209524) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1209509) /Source="Nicolas_upshifts" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1209539..1209546) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1209544..1210356 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389105.1" /db_xref="EnsemblGenomes-Gn:BSU12230" /db_xref="EnsemblGenomes-Tr:CAB13080" /db_xref="GOA:O34394" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG13197" /db_xref="UniProtKB/Swiss-Prot:O34394" /translation="MGKGLLGKRVAIGGSRKTEEISTIIEKQGGIPVIRPLQGTVYLA EKQVEPDLRTFAEEKADWVIFTTGIGLETLVDMAEKIGLKDEFLQAIRQAKAACRGYK TLSALKKLGITPEASDEDGTTRGLIRSLEPHDFSGKTVMVQLHGEKAPALMAFLEEKG ASVLPILPYQHIPPEEETVERLCRELMNDEVDAVCFTTAIQVRSLFDFAKGRGYINEV KKVFEERAIAAAVGKVTAEALREEGITRLLAPEIERMGAMIVELAKYYEEKE*" /label="yjjA CDS" gene 1209544..1210356 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /label="yjjA gene" downshifts 1210335 /Source="Nicolas_upshifts" /id="D681" /incds=0 /nref=196 /ntot=254 /MaxReadThrough="3.61369" /MaxDrop="5.73094" /score="10.6328997" /energy="-14.5" /TU="U1002" /idTUdmin="U1002" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1210402..1211154) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_389106.1" /db_xref="EnsemblGenomes-Gn:BSU12240" /db_xref="EnsemblGenomes-Tr:CAB13081" /db_xref="GOA:O34684" /db_xref="InterPro:IPR005226" /db_xref="SubtiList:BG13198" /db_xref="UniProtKB/Swiss-Prot:O34684" /translation="MDYLSLSLTMIFVLIALFLSKSFKAGVEKDMIIATIRAAVQLLI IGYVLSLIFRGDHPVFILLMVLLMLAVAAQNVIKRKKNTIGSFWRVFAALAIVEIVTQ GILLSLHIIPLTARYVIPISGMVIGNSMVLSSLFLNRLNSEVGVRKEEIQLILSLGGT PKQSIQRILTSAMKMSMIPTLESQKTLGLVQLPGMMTGQILAGADPIQAVRFQLLIVF TTMASAALTCVILSVLTYPSLFTVHQQLKQNE*" /label="yjkA CDS" gene complement(1210402..1211154) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /label="yjkA gene" downshifts complement(1210411) /Source="Nicolas_upshifts" /id="D682" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="0.924970000000001" /MaxDrop="3.5673" /score="13.1058081" /energy="-12.8" /TU="NA" /idTUdmin="U1001" /TUdmin="-1210" /isTUend="FALSE" /label="downshifts" CDS complement(1211154..1211906) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389107.1" /db_xref="EnsemblGenomes-Gn:BSU12250" /db_xref="EnsemblGenomes-Tr:CAB13082" /db_xref="GOA:O34756" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13199" /db_xref="UniProtKB/Swiss-Prot:O34756" /translation="MEANDQTQNIPAISFRSVRKSYKQDGQTYDVLQDVTGDIQQGAI VAVLGPSGSGKSTLLSMCNLMRTPDSGEVNIYGKEVREWNVNELRRTAALAFQSAPVL DGTVRDNLSLVQRLHQSQLYSPEKLASLAGLPPELLDRSARDLSGGQRQRLSLARTLS NPSSILLLDEITSALDPVSALEIEELIKRQHQEKKWTVMWVTHNMEQAKRIADTIWFM ADGRLLEIAETDTFFSAPQHEAAKEFLKGGTR*" /label="yjkB CDS" gene complement(1211154..1211906) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /label="yjkB gene" CDS complement(1212026..1213000) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14627822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389108.1" /db_xref="EnsemblGenomes-Gn:BSU12260" /db_xref="EnsemblGenomes-Tr:CAB13083" /db_xref="GOA:O34428" /db_xref="InterPro:IPR032713" /db_xref="SubtiList:BG13200" /db_xref="UniProtKB/Swiss-Prot:O34428" /translation="MKAIVIGILASLFFAVTFILNRAMELSGGSWLWSSSLRFIFMVP FLCLIVIMRGTFTPLLLEMRKKPFYWIKWSFVGFVLFYAPITFAAAYGPGWLIAGTWQ ITIVAGVLLSPLFYVKQDMPGGPQLIRQKIPLVSLGTSVIILIGAALIQLQHAESLSG RMLLFSVLPVVIAAFAYPLGNRRMLEEYGGRLDTFQRVLGMTLASLPFWLILAAYGWW SDGLPTASQTVQSFIVAVSSGIIATVLFFWATDMVRDNPQKLAAVEATQSGEVIFALL GEIVLLSGVFPSLLSFAGLFIIIAGMMLHTFASQPRKPKKKAQSNLTA*" /label="yjlA CDS" gene complement(1212026..1213000) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /label="yjlA gene" downshifts complement(1212061) /Source="Nicolas_upshifts" /id="D683" /incds=0 /nref=1 /ntot=95 /MaxReadThrough="1.84381" /MaxDrop="2.54799" /score="4.80318278" /energy="-14.5" /TU="NA" /idTUdmin="U1004" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1213021..1213040) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1213047) /Source="Nicolas_upshifts" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1213049..1215555) /Source="Nicolas_S_feature" /locus_tag="new_1297643_1300149_c" /HighExp="Lbstat, S2, M0t90, nit, BT, M40t90, ferm, BC, C30, Gly" /AntisenseName="ndh" /AntisenseCor="-0.74506751931257098" /AntisenseRegPval="-48.1" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S449" promotor_-35 complement(1213055..1213062) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1213083..1213089 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1213104..1213122 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1213107 /Source="Nicolas_upshifts" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="upshifts" CDS 1213132..1213629 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10704478" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; cupin family" /protein_id="NP_389109.1" /db_xref="EnsemblGenomes-Gn:BSU12270" /db_xref="EnsemblGenomes-Tr:CAB13084" /db_xref="GOA:O34612" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014500" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG13201" /db_xref="UniProtKB/Swiss-Prot:O34612" /translation="MERETQTYFFPDDGRIPNHPDFPLVVYQNALKDTGLAERIVTRH GWSNSWSGSVFPYHHYHSNTHEVLIALRREAVIQFGGEKGAAIPFKSGDAVVIPAGVG HKKLSSSPDFTVLGAYPGGVQYDMKTGKPNEREEAVKQIKQAALPANDPITGKREPLL EIWVK*" /label="yjlB CDS" gene 1213132..1213629 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /label="yjlB gene" S_feature 1213630..1213743 /Source="Nicolas_S_feature" /locus_tag="new_1298224_1298337" /HighExp="Etha, M9-stat, B60, Salt, Gly, LPhT, Heat, Sw, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S450" promotor_-35 1213723..1213727 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1213743..1213762 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1213745..1214017 /Source="Nicolas_S_feature" /locus_tag="new_1298339_1298611" /HighExp="LBGtran, dia5, Lbexp, LBGexp, dia0, HPh, aero, LPh, BMM, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S451" upshifts 1213745 /Source="Nicolas_upshifts" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="upshifts" CDS 1214018..1214440 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16513748, 17015645, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389110.1" /db_xref="EnsemblGenomes-Gn:BSU12280" /db_xref="EnsemblGenomes-Tr:CAB13085" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13202" /db_xref="UniProtKB/Swiss-Prot:O34633" /translation="MPETIDQTNASVSQSQQDLIDQLLKPEVQESLTVLVDQLPKLTE LVNILTKSYDFAQSVATDEVLKSDTVGAITEILEPVKETAKEVAATAIEAKDRAEASN ETIGLFGLLRMLKDPQAQKLFRFANSYLEVMNERENQK*" /label="yjlC CDS" gene 1214018..1214440 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /label="yjlC gene" CDS 1214480..1215658 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /EC_number="1.6.99.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6816592, 16513748, 17015645, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6816592, 16513748, 17015645, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH dehydrogenase" /protein_id="NP_389111.1" /db_xref="EnsemblGenomes-Gn:BSU12290" /db_xref="EnsemblGenomes-Tr:CAB13086" /db_xref="GOA:P80861" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13203" /db_xref="UniProtKB/Swiss-Prot:P80861" /translation="MSKHIVILGAGYGGVLSALTVRKHYTKEQARVTVVNKYPTHQII TELHRLAAGNVSEKAVAMPLEKLFKGKDIDLKIAEVSSFSVDKKEVALADGSTLTYDA LVVGLGSVTAYFGIPGLEENSMVLKSAADANKVFQHVEDRVREYSKTKNEADATILIG GGGLTGVELVGELADIMPNLAKKYGVDHKEIKLKLVEAGPKILPVLPDDLIERATASL EKRGVEFLTGLPVTNVEGNVIDLKDGSKVVANTFVWTGGVQGNPLVGESGLEVNRGRA TVNDFLQSTSHEDVFVAGDSAVYFGPDGRPYPPTAQIAWQMGELIGYNLFAYLEGKTL ETFKPVNSGTLASLGRKDAVAIIGANSTPLKGLPASLMKEASNVRYLTHIKGLFSLAY *" /label="ndh CDS" gene 1214480..1215658 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /label="ndh gene" promotor_no_box 1215489..1215589 /Source="Nicolas_upshift_promotors" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(1215547..1215565) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1215549 /Source="Nicolas_upshifts" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1215555) /Source="Nicolas_upshifts" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1215577..1215585) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1215657 /Source="Nicolas_upshifts" /id="D684" /incds=0 /nref=220 /ntot=278 /MaxReadThrough="2.01042" /MaxDrop="8.69373" /score="30.6421047" /energy="-23.1" /TU="NA" /idTUdmin="U1005" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 1215766..1215773 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1215788..1215807 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1215813 /Source="Nicolas_upshifts" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="upshifts" CDS 1215856..1217277 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /EC_number="5.3.1.12" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galacturonate isomerase" /protein_id="NP_389112.1" /db_xref="EnsemblGenomes-Gn:BSU12300" /db_xref="EnsemblGenomes-Tr:CAB13087" /db_xref="GOA:O34808" /db_xref="InterPro:IPR003766" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13204" /db_xref="UniProtKB/Swiss-Prot:O34808" /translation="MEPFMGKNFLLKNETAVSLYHNYAKDMPIIDYHCHLSPKEIYEN KTFQNITEAWLYGDHYKWRIMRANGIEETYITGDAPDEEKFMAWAKTVPMAIGNPLYN WTHLELQRFFGIYEILNEKSGSAIWKQTNKLLKGEGFGARDLIVKSNVKVVCTTDDPV DSLEYHLLLKEDKDFPVSVLPGFRPDKGLEINREGFPEWVQALEDAAAISITTYDEFL KALEKRVRFFHSAGGRVSDHAIDTMVFAETTKEEAGRIFSDRLQGTEVSCEDEKKFKT YTLQFLCGLYAELDWAMQFHINALRNTNTKMMKRLGPDTGYDSMNDEEIAKPLYKLLN SVEMKNQLPKTILYSLNPNDNYVIASMINSFQDGITPGKIQFGTAWWFNDTKDGMLDQ MKALSNVGLFSRFIGMLTDSRSFLSYTRHEYFRRIVCNLIGEWVENGEVPRDMELLGS IVQGICYDNAKHYFQFQEEKANV*" /label="uxaC CDS" gene 1215856..1217277 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /label="uxaC gene" CDS 1217345..1218724 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+:altronate/mannonate symporter" /protein_id="NP_389113.1" /db_xref="EnsemblGenomes-Gn:BSU12310" /db_xref="EnsemblGenomes-Tr:CAB13088" /db_xref="GOA:O34961" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13205" /db_xref="UniProtKB/Swiss-Prot:O34961" /translation="MRTELANKVVSVETEKRLSLKEKMSYGFGDFGNGFMFDLGQIYL LKYFTDVAGIPAAMAGGIFLVSKLFAAITDPIVGSSIDYRKNIGKRGKFRPYLLIGSI VLAVLTVLIFLSPNVSTTGKLIYAYASYMIWGIGYSFVNIPYGSLGAAMTQNSEDRTS ISTFRQIGSLGALFITSVAVMPLLVKFDNPKVGYPVVMGLFAALGVFWFYICYRNCKE RIIISEAPKEKLTLSSVVKTFITNKPLLTLVLMTIFSISAYNIKSAMLVYFAQYNLGN VELMAYMNFIIIGSSFLGVVFLPKLVKMFGKKRTAMIGFGISVAADLINFMLPSNVYV FTILASIAFIGISIPNGITWALVSDIIDYGEWKSGERKEATTYSLFNFSRKLAQSLSG FLSGIGLGIIGYVPNAVQTAQALIGIKALLLLYPAIALALAMFIIGFLYKLTDQQHAQ IVQDLHQKS*" /label="exuM CDS" gene 1217345..1218724 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /label="exuM gene" promotor_-10 complement(1217864..1217883) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1217869) /Source="Nicolas_upshifts" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1217897..1217904) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1218749 /Source="Nicolas_upshifts" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1218759..1218766 /Source="Nicolas_upshift_promotors" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1218761..1218828 /Source="Nicolas_S_feature" /locus_tag="new_1303355_1303422" /HighExp="S4, S5, S6, S3, S8, S7, T5.0H, T4.0H, T3.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S452" CDS 1218829..1219842 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655, 16788182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389114.1" /db_xref="EnsemblGenomes-Gn:BSU12320" /db_xref="EnsemblGenomes-Tr:CAB13089" /db_xref="GOA:O34736" /db_xref="InterPro:IPR003767" /db_xref="InterPro:IPR036111" /db_xref="SubtiList:BG13206" /db_xref="UniProtKB/Swiss-Prot:O34736" /translation="MKTITIAAEEAKELVWQKLDGAGLNERDAEKVADVLVHADLRNV HSHGVLHTEHYVNRLLAGGINPGAQPVFKETGPVTGVLDGDDGFGHVNCDMAMDHAID MAKKKGVGMVTAVNSSHCGALSYFVQKAADEKLIGMAMTHTDSIVVPFGGRTPILGTN PIAYGVPAKHKKPFILDMATSKVAFGKILQAREEGKEIPEGWGVDENGEAVTDPDKVV SLSTFGGPKGYGLSIVVDVFSGLLAGAAFGPHIAKMYNGLDQKRKLGHYVCAINPSFF TDWDTFLEQMDAMIDELQQSPPAVGFERVYVPGEIEQLHEERNKKNGISIARSVYEFL KSR*" /label="yjmC CDS" gene 1218829..1219842 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /label="yjmC gene" CDS 1219848..1220867 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389115.1" /db_xref="EnsemblGenomes-Gn:BSU12330" /db_xref="EnsemblGenomes-Tr:CAB13090" /db_xref="GOA:O35045" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13207" /db_xref="UniProtKB/Swiss-Prot:O35045" /translation="MKAVQVRKAYDLVTAEVKKPVLSKDDEVLVKVKRVGICGSDMHI YHGTNPLATLPRVIGHEVTGQVEAVGANVQSLKPGDHVVIEPISYCGSCYACRKGRPN VCAKLSVFGVHEDGGMREYIVLPERQLHAVSKDLPWEEAVMAEPYTIGAQAVWRGQVE KGDTVLIQGAGPIGICVLKMAKLAGAAVMMTDLNNERLAFAKENGADAVVNVQAEHVA ERVLEWTGNEGANVVIDAVCLPETFALSIEAVSPAGHVVVLGFDERAAQISQLPITKK EVTITGSRLQTNQFPKVVELLNGGRLMHNGLVTHTFSVDDVHHAFQFIKEHPDQVRKA VITFD*" /label="yjmD CDS" gene 1219848..1220867 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /label="yjmD gene" CDS 1220892..1221971 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /EC_number="4.2.1.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9579062, 9882655, 10368143, 25145794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-mannonate dehydratase" /protein_id="NP_389116.1" /db_xref="EnsemblGenomes-Gn:BSU12340" /db_xref="EnsemblGenomes-Tr:CAB13091" /db_xref="GOA:O34346" /db_xref="InterPro:IPR004628" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG13208" /db_xref="UniProtKB/Swiss-Prot:O34346" /translation="MNMTFRWYGRGNDTVTLEYVKQIPGVKGIVWALHQKPVGDVWEK EEIRAETEYIQSYGFHAEVVESVNVHEAIKLGNEERGRYIENYKQTIRNLAGFGVKVI CYNFMPVFDWTRTDMFRPLEDGSTALFFEKAKVESLDPQELIRTVEEASDMTLPGWEP EKLARIKELFAAYRTVDEEKLWDNLSFFLQEILPVAEAYGVQMAIHPDDPPWPIFGLP RIITGEASYKKLRAISDSPSNCITLCTGSMGANPANDMVEIAKTYAGIAPFSHIRNVK IYENGDFIETSHLTKDGSINIQGVMEELHKQDYEGYVRPDHGRHLWGEQCRPGYGLYD RALGIMYLNGLWDAYEAMAKKEVGI*" /label="uxuA CDS" gene 1220892..1221971 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /label="uxuA gene" CDS 1221968..1222804 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /EC_number="1.1.1.57" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructuronate reductase" /protein_id="NP_389117.1" /db_xref="EnsemblGenomes-Gn:BSU12350" /db_xref="EnsemblGenomes-Tr:CAB13092" /db_xref="GOA:O34896" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13209" /db_xref="UniProtKB/Swiss-Prot:O34896" /translation="MIPLHENLAGKTAVITGGSGVLCSAMARELARHGMKVAILNRTA EKGQAVVKEITAAGGTACAVAADVLDRMSLERAKEDILGQFGAVDLLINGAGGNHPDA ITDVETYEEAGEGQSFFDMDERGFLTVFSTNFTGAFLASQVFGKELLKADSPAIINLS SMSAYSPMTKVPAYSAAKASINNFTMWMAVHFAETGLRVNAIAPGFFLTKQNHDLLIN QDGTFTSRSHKIIAGTPMKRFGKPEDLLGTLLWLADESYSGFVTGITVPVDGGFMAYS GV*" /label="uxuB CDS" gene 1221968..1222804 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /label="uxuB gene" CDS 1222852..1224120 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8320243, 9579062, 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="hexuronate transporter" /protein_id="NP_389118.1" /db_xref="EnsemblGenomes-Gn:BSU12360" /db_xref="EnsemblGenomes-Tr:CAB13093" /db_xref="GOA:O34456" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13210" /db_xref="UniProtKB/Swiss-Prot:O34456" /translation="MFSKDKLPVILFLFLAGVINYLDRSALSIAAPFIQDDLTLSATQ MGLIFSSFSIGYAIFNFLGGVASDRYGAKLTLFVAMVVWSLFSGAVALAFGFVSLLII RILFGMGEGPLSATINKMVNNWFPPTQRASVIGVTNSGTPLGGAISGPIVGMIAVAFS WKVSFVLIMIIGLIWAVLWFKFVKEKPQETIKEAPAIKAETSPGEKIPLTFYLKQKTV LFTAFAFFAYNYILFFFLTWFPSYLVDERGLSVESMSVITVIPWILGFIGLAAGGFVS DYVYKKTARKGVLFSRKVVLVTCLFSSAVLIGFAGLVATTAGAVTLVALSVFFLYLTG AIYWAVIQDVVDQNNVGSVGGFMHFLANTAGIIGPALTGFIVDQTGTFSGAFLLAGGL AVFASLAVIRFVRPIIGKPAGTEAENPVSY*" /label="exuT CDS" gene 1222852..1224120 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /label="exuT gene" promotor_-35 1224064..1224067 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1224083..1224087 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1224085 /Source="Nicolas_upshifts" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1224153..1224172 /Source="Nicolas_upshift_promotors" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1224153 /Source="Nicolas_upshifts" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="upshifts" CDS 1224208..1225209 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9579062, 9882655" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9579062, 9882655; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_389119.1" /db_xref="EnsemblGenomes-Gn:BSU12370" /db_xref="EnsemblGenomes-Tr:CAB13094" /db_xref="GOA:Q9JMQ1" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13211" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ1" /translation="MVTIKDIAKLANVSHTTVSRALNNSPYIKEHTKKKILELAEQLN YTPNVNAKSLAMQKSHTIGLFFTSITNGTSHSFFADTIKGVNQAISEDYNLYVRGIDD LKNYDSVTPMRYDGIILMSQSDIDNSFIYHIREKNIPLVVLNRDIDDRTITNILSNDK EGSQEAVEYFIQSGHQDIAIIEGIEGFKSSQQRKEGYLSALIQHHIPIKHEYSVKGQY DMESGFQAMERLLALPNPPTAVFCSNDDMAIGAMNAIFAKGLRVPDDISVIGFDDIGF SQYITPRLSTVKRPVEKISVLGAQKLLSLISEPETKAEKILENTEFMVRDSVRRLTT* " /label="exuR CDS" gene 1224208..1225209 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /label="exuR gene" promotor_no_box complement(1224891..1224991) /Source="Nicolas_upshift_promotors" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1224931) /Source="Nicolas_upshifts" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1225185 /Source="Nicolas_upshifts" /id="D685" /incds=0 /nref=2 /ntot=132 /MaxReadThrough="2.47166" /MaxDrop="3.11543" /score="12.2153519" /energy="-7.4" /TU="NA" /idTUdmin="U1011" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1225286..1226728 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /EC_number="1.1.1.58" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tagaturonate reductase (altronate oxidoreductase)" /protein_id="NP_389120.1" /db_xref="EnsemblGenomes-Gn:BSU12380" /db_xref="EnsemblGenomes-Tr:CAB13095" /db_xref="GOA:O34354" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023668" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13212" /db_xref="UniProtKB/Swiss-Prot:O34354" /translation="MQKLNKNVYDHYTQYPEKILQFGEGNFLRGFIDWQIDQLNQHTD FNGSVAVVQPRGSEKIKRLNEQDGLYTLFLQGMKDGEAVNEHMIINSISRGIDLFSDY EAYKELASSERLRFIISNTTEAGIVCDEKDRLEDRPQKTFPGKLTAFLYFRYQAFKGD QTKGCVLIPCELIENNGEKLRETVLHYAHLWKLEEGFTQWIHEANTFCNSLVDRIVPG FPVDSIDEITADLGYQDDLIVVGEQYYLWVIEGPDWIGKELPFAAAGLHTKIVSDLTP YRTKKVRILNGAHTAMTPVALLYGLKTVRDAVEHPEVGRFIRELIDDEILPVLKMEGL SQYADDVLNRFKNPYIKHYLESIALNAISKFKTRNLPTLKEYAEQKGQLPERLVFSFS ALLYFYHDNETLQDDPAVLQFFKEVWCQEDGDMLRIASRVLGEQRLWGADLNEIPKLT DRVAVYLNHIHELGMQRALEQYCIQGGEVR*" /label="uxaB CDS" gene 1225286..1226728 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /label="uxaB gene" CDS 1226725..1228218 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /EC_number="4.2.1.7" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="altronate dehydratase" /protein_id="NP_389121.2" /db_xref="EnsemblGenomes-Gn:BSU12390" /db_xref="EnsemblGenomes-Tr:CAB13096" /db_xref="GOA:O34673" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="SubtiList:BG13213" /db_xref="UniProtKB/Swiss-Prot:O34673" /translation="MKSFIKIHKQDNVLLALRDIQKGERLHAYGVSIEVKDDIKRGHK IALQSIKENDSIVKYGFPIGHASQDISIGEHIHVHNTKTNLSDIQLYSYTPRFDENPY SNENRTFKGFRRENGDAGVRNELWIVPTVGCVNGIAEKMLQRFVRETGDIAPFDNVLV LKHQYGCSQLGDDHENTKQILLNAIRHPNAGGVLVLGLGCENNELARMKEALQDVNLK RVKFLESQSVTDEMEAGVALLKEIHEAAKGDKREDIPLSELKIGLKCGGSDGFSGITA NPLLGRFSDYLIAQGGSTVLTEVPEMFGAETILMQRAANEEVFHKIVDLINDFKQYFI KHDQPVYENPSPGNKAGGISTLEDKSLGCTQKAGISPVTDVLKYGEVLKTKGLTLLSA PGNDLIASSALAAAGCQIVLFTTGRGTPFGTFVPTVKVATNTELYEAKPHWIDFNAGL LAEDDVHEEYVLREFIHYMIEVASGQLVNHEKNDFKELAIFKSGVTL*" /label="uxaA CDS" gene 1226725..1228218 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /label="uxaA gene" CDS complement(1228257..1229021) /gene="yjnA" /locus_tag="Delta6_BSU_12400_SNPvariant" /old_locus_tag="BSU_12400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389122.1" /db_xref="EnsemblGenomes-Gn:BSU12400" /db_xref="EnsemblGenomes-Tr:CAB13097" /db_xref="GOA:O34578" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13214" /db_xref="UniProtKB/Swiss-Prot:O34578" /modified_by="User" /translation="MSVSIILMGLFVGALVGLTGVGGAALLTPLLIVLGINPSIAVGT DLVYNSITKLFGVASHWRQKTINFKLVKYLAIGGIPSASLAIGILHLFPAFHQHQEEI IKHALGYVLTLVAISIIVRLFLDRKLRPNRWQLMPLENKRALTILIGVVFGFIVGLTS IGSGSLFAIAMIYLFNMKASQIVGTDIAHAFLLVTAAGILNASFGSVDYMLAANLLLG SIPGVLIGSHLSPRFSPRPLQFIMASIILVSGLKLI*" /label="Delta6_BSU_12400_SNPvariant" gene complement(1228257..1229021) /gene="yjnA" /locus_tag="Delta6_BSU_12400_SNPvariant" /old_locus_tag="BSU_12400" /modified_by="User" /label="Delta6_BSU_12400_SNPvariant" downshifts complement(1228276) /Source="Nicolas_upshifts" /id="D686" /incds=0 /nref=96 /ntot=170 /MaxReadThrough="1.34004" /MaxDrop="4.60564" /score="6.47747687" /energy="-11.3" /TU="NA" /idTUdmin="U1015" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" Polymorphism join(1228789,1228791) /Source="geneious" /ID="SNP_BsDelta6_1313384_1313384" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="S -> G" /CDS_Position=232 /Change="T -> C" /Codon_Change="AGT -> GGT" /Coverage=150 /locus_tag="BSU_12400" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=149 /comment="Delta6_BSU_12400_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" SCAR join(1229048,1229055) /created_by="User" /modified_by="User" /label="TF8A" N_region 1229049..1229054 /created_by="User" /note_="EcoRI site (GAATTC)" /modified_by="User" /label="TF8A" CDS <1229057..1229377 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /EC_number="3.5.1.28" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7921239, 9555893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921239, 9555893; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_389164.1" /db_xref="EnsemblGenomes-Gn:BSU12810" /db_xref="EnsemblGenomes-Tr:CAB13138" /db_xref="GOA:P39800" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR002502" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="InterPro:IPR036505" /db_xref="InterPro:IPR036779" /db_xref="PDB:3HMB" /db_xref="PDB:3RDR" /db_xref="SubtiList:BG10962" /db_xref="UniProtKB/Swiss-Prot:P39800" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /translation="PNLIRVGQVLIVSAPSAAEKPELYPLPDGIIQLTTPYTSGEHVF QVQRALAALYFYPDKGAVNNGIDGVYGPKTADAVARFQSVNGLTADGIYGPATKEKIA AQLS*" /label="Delta6_pseudo_BSU_12810" gene <1229057..1229377 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /label="Delta6_pseudo_BSU_12810" downshifts 1229386 /Source="Nicolas_upshifts" /id="D696" /incds=0 /nref=29 /ntot=162 /MaxReadThrough="3.77255" /MaxDrop="5.00305" /score="30.9009227" /energy="-12.5" /TU="U1029,U1033" /idTUdmin="U1029" /TUdmin="-152" /isTUend="FALSE" /label="downshifts" S_feature complement(1229395..1229598) /Source="Nicolas_S_feature" /locus_tag="new_1348200_1348403_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.798" /TUlongSig="NA" /TUlongPSig="NA" /label="S458" CDS complement(1229414..1229551) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type r: regulator" /codon_start=1 /transl_table=11 /product="three component toxin / antitoxin / antitoxin SpoIISABC, antitoxin C" /protein_id="YP_009513952.1" /translation="MSGDTVKKLVRRVKFVDYGRFGLSGYSLRVRERSAGIIKKLKKK K*" /label="spoIISC CDS" gene complement(1229414..1229551) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /label="spoIISC gene" downshifts complement(1229438) /Source="Nicolas_upshifts" /id="D697" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="2.75573" /MaxDrop="4.3776" /score="24.0186344" /energy="-12.5" /TU="U1034" /idTUdmin="U1035" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1229637..1229807) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptotic control system component B (antitoxin B)" /protein_id="NP_389165.1" /db_xref="EnsemblGenomes-Gn:BSU12820" /db_xref="EnsemblGenomes-Tr:CAB13139" /db_xref="GOA:O34800" /db_xref="InterPro:IPR025897" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12678" /db_xref="UniProtKB/Swiss-Prot:O34800" /translation="MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKEN ERLIDEYKRKKA*" /label="spoIISB CDS" gene complement(1229637..1229807) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /label="spoIISB gene" downshifts complement(1229643) /Source="Nicolas_upshifts" /id="D698" /incds=0 /nref=6 /ntot=86 /MaxReadThrough="4.69899" /MaxDrop="3.0872" /score="24.0186344" /energy="-12.5" /TU="U1034,U1035" /idTUdmin="U1035" /TUdmin="-205" /isTUend="FALSE" /label="downshifts" CDS complement(1229807..1230553) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptosis factor (ABC toxin/antitoxin/antitoxin system)" /protein_id="NP_389166.1" /db_xref="EnsemblGenomes-Gn:BSU12830" /db_xref="EnsemblGenomes-Tr:CAB13140" /db_xref="GOA:O34853" /db_xref="InterPro:IPR025940" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12677" /db_xref="UniProtKB/Swiss-Prot:O34853" /translation="MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLL FVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAFIFLSAYVKKLAGSELETDTREI LEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSD SIVTEFDYLLFTSLTSIYDLVLPIEEEGEG*" /label="spoIISA CDS" gene complement(1229807..1230553) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /label="spoIISA gene" promotor_-10 complement(1230388..1230407) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1230405) /Source="Nicolas_upshifts" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1230423..1230430) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1230579..1230597) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1230592) /Source="Nicolas_upshifts" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1230613..1230618) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1230663..1231664) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10784039, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative low-affinity inorganic phosphate transporter" /protein_id="NP_389167.2" /db_xref="EnsemblGenomes-Gn:BSU12840" /db_xref="EnsemblGenomes-Tr:CAB13141" /db_xref="GOA:O34436" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13226" /db_xref="UniProtKB/Swiss-Prot:O34436" /translation="MDILLILTILIVICALAFDFINGFHDTANAIATSVSTKALKPRH AIILAAVMNFVGAMTFTGVAKTITKDIVDPYTLENGSVVILAALLAAIAWNLITWYYG IPSSSSHAIIGAIAGAAIAAAGFAALNYKGFIKIIEALILSPIIAFVLGFILYSIVKL IFKDSNLAKTNKQFRRVQIVTAALQSYTHGTNDAQKAMGIITMALITANLHTSANDIP TWVQFACATAMGLGTSIGGWKIIKTVGGKIMKIRPVNGVSADLTGAAIIFGATFIHLP VSTTHVISSSILGVGASHRVKGVNWGTAKRMLITWVITLPISATLGAIAYFILNMIF* " /label="pitB CDS" gene complement(1230663..1231664) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /label="pitB gene" downshifts complement(1230692) /Source="Nicolas_upshifts" /id="D699" /incds=0 /nref=205 /ntot=253 /MaxReadThrough="3.49591" /MaxDrop="5.81942" /score="21.8061263" /energy="-11" /TU="U1036,U1038" /idTUdmin="U1037" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1231677..1232294) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696772, 14563871; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PitB transporter accessory protein" /protein_id="NP_389168.1" /db_xref="EnsemblGenomes-Gn:BSU12850" /db_xref="EnsemblGenomes-Tr:CAB13142" /db_xref="InterPro:IPR018445" /db_xref="SubtiList:BG13225" /db_xref="UniProtKB/Swiss-Prot:O34454" /translation="MIRRKKDKFSLLLTEIAKNIDETAEYFVNFKVTNQTTLKEFADT LKEYETKGDNHVHVMIKELNKAFITPIEREDILQLTNSLDDVLDGIEHFSAMMEIFSI TSSDEHIDKFSGYIRECAKEILITIELLAENRLKDIQPHAIKIKEYEHSCDNLHRKSL KNLFGNETDPIKVIQYREIYETLEEIADSCQSVANNLETIIMKNA*" /label="ykaA CDS" gene complement(1231677..1232294) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /label="ykaA gene" promotor_-10 complement(1232330..1232349) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1232332) /Source="Nicolas_upshifts" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1232334..1232431) /Source="Nicolas_S_feature" /locus_tag="new_1351139_1351236_c" /HighExp="H2O2, Etha, dia15, Diami, Paraq, Heat, dia5, Salt, LBGstat, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.972, 0.987" /TUlongSig="SigA" /TUlongPSig="0.992" /label="S459" promotor_-35 complement(1232365..1232369) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1232411..1232430) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1232431) /Source="Nicolas_upshifts" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1232445..1232452) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1232476..1232495) /Source="Nicolas_upshift_promotors" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1232488) /Source="Nicolas_upshifts" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1232570..1233886) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17344220, 19419962, 20610400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17344220, 19419962, 20610400; Product type t : transporter" /codon_start=1 /transl_table=11 /product="serine / threonine exchanger" /protein_id="NP_389169.1" /db_xref="EnsemblGenomes-Gn:BSU12860" /db_xref="EnsemblGenomes-Tr:CAB13143" /db_xref="GOA:O34739" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG13227" /db_xref="UniProtKB/Swiss-Prot:O34739" /translation="MHTEDNGLKKEIGLLFALTLVIGTIIGSGVFMKPGAVLAYSGDS KMALFAWLLGGILTLAGGLTIAEIGTQIPKTGGLYTYLEEVYGEFWGFLCGWVQIIIY GPAIIGALGLYFGSLMANLFGWGSGLSKVIGIIAVLFLCVINIIGTKYGGFVQTLTTI GKLIPIACIIVFGLWKGDQHIFTAVNESISDMNFGAAILATLFAYDGWILLAALGGEM KNPEKLLPRAMTGGLLIVTAIYIFINFALLHILSANEIVTLGENATSTAATMLFGSIG GKLISVGIIVSIFGCLNGKVLSFPRVSFAMAERKQLPFAEKLSHVHPSFRTPWIAISF QIALALIMMLISNPDKLSEISIFMIYIFYVMAFFAVFILRKRAKGEKRAYSVPLYPFM PILAIAGSFFVLGSTLITDTMSCGLSILIGLAGLPVYYGMKKRKAS*" /label="steT CDS" gene complement(1232570..1233886) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /label="steT gene" downshifts complement(1232585) /Source="Nicolas_upshifts" /id="D700" /incds=0 /nref=3 /ntot=92 /MaxReadThrough="3.59461" /MaxDrop="3.97157" /score="23.3119204" /energy="-14.4" /TU="U1039" /idTUdmin="U1039" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1233933..1233952) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-10" upshifts complement(1233949) /Source="Nicolas_upshifts" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="upshifts" promotor_-35 complement(1233967..1233970) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-35" promotor_-35 1234169..1234176 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1234191..1234210 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1234203..1234274 /Source="Nicolas_S_feature" /locus_tag="new_1353008_1353079" /HighExp="Etha, dia15, Salt, Heat, dia5, Diami, H2O2, M9-stat, MG 25, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.964" /TUlongSig="NA" /TUlongPSig="NA" /label="S460" upshifts 1234203 /Source="Nicolas_upshifts" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="upshifts" CDS 1234275..1235225 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /EC_number="1.13.11.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17407181, 17725564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 17725564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroquinone-specific extradiol dioxygenase" /protein_id="NP_389170.1" /db_xref="EnsemblGenomes-Gn:BSU12870" /db_xref="EnsemblGenomes-Tr:CAB13144" /db_xref="GOA:O34689" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13228" /db_xref="UniProtKB/Swiss-Prot:O34689" /translation="MKVNGIHHVSALTADAQKNLDFYKKVLGLKLVKKSVNQDEPTMY HLFYGDEVANPGTELTFFEIPRIAPFHAGTNSISSIGLRVPGTEALHYWKERFEEQQV THSGISKRAGRDILAFQDHEGQRLVLTADEEGKGYGLPVKQSGIPEEFSFRGLGPVEL TVPYAEPTLHVLTNILGFTEISREPVEGQGTAVILESGEGGAATEIHLIERNDLPRER QGKGSVHHVAFRVRDEEELAGWHRIISREGFSNSGIVERYYFKALYFREPNGILFELS TDGPGFMVDENLDELGQTIALPPYLEHRRAEIEAKLKPIQ*" /label="mhqA CDS" gene 1234275..1235225 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /label="mhqA gene" downshifts 1235213 /Source="Nicolas_upshifts" /id="D701" /incds=0 /nref=95 /ntot=231 /MaxReadThrough="0.70251" /MaxDrop="5.11652" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1040" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS 1235326..1235472 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513953.1" /translation="MLIGRNGLKPFANMGDWYGMASAKILSLFINSLFIFACYTISKL DKKE*" /label="hypothetical protein CDS" gene 1235326..1235472 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /label="gene" CDS 1235480..1237630 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane glycosyl transferase" /protein_id="NP_389171.2" /db_xref="EnsemblGenomes-Gn:BSU12880" /db_xref="EnsemblGenomes-Tr:CAB13145" /db_xref="GOA:O34575" /db_xref="SubtiList:BG13229" /db_xref="UniProtKB/Swiss-Prot:O34575" /translation="MEKKKRELDIVLLLILLASAFLNIYNIWKDDTVNPYYTAAVTSM MQSFHNFFYASFDAAGFITVDKPPVTYQIQTISALIFGMHGWSVILPQALAGVGSVLL MYLLIKPTFGKTAARIASFVMACTPIAVAVARTNNVDALLVFFLLLATWLLFKAIRKG KLIWLLAAFFVVGVGFNTKMLQAYMILPAFLLFYLIAANATIKKKIVSLVSALAVLAA VSLSWPLIVDNIPASKRPYIGSSQTNSVLELAFGYNGIQRLTGQNSGGGQGAPNKDAS KEMSSSDNTQAPPNQSSSNSSSSDGKSSNGNMAAPPSNGQMPSGGQGGPPSGGDGGQG GPGGDGGKGGTGTGSKMQSGSGMFGTGTPGPLRLFQQELSDQISWLLPFAIFGIAGLL IAGARERRRLSVEQKETVFWVAWLVPIAGFFSVAEFFHHYYLIMLAPPIAALVGAGWV ALVHLYRNQTGWKAWLLPGAIIATTGFELFILRNYNDQIGVGWSIGVGVIGVLSAIAL LLFKQRQKPFSYYVSLAALLALLVMPMYWASTPLLYGGNSSLPETGPQLASMSGKGMG MSDATVNEKLIKYLEENNSGAEYLFATTDSNTAAPYIIKTKKAVMAIGGYSGSDPAIT LTQFKKLVKEGKVKYFLASGMGRGGNNDIVEWVEKNGKEVASEKWQSSSDQKTENTDS ADTSSSKASGENGKMGGPGGMNQSATLYELHADE*" /label="ykcB CDS" gene 1235480..1237630 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /label="ykcB gene" promotor_no_box 1236369..1236469 /Source="Nicolas_upshift_promotors" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1236429 /Source="Nicolas_upshifts" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1236517 /Source="Nicolas_upshifts" /id="D702" /incds=1 /nref=4 /ntot=10 /MaxReadThrough="0.56615" /MaxDrop="4.44711" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1041" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1237642..1238613 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /EC_number="2.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389172.2" /db_xref="EnsemblGenomes-Gn:BSU12890" /db_xref="EnsemblGenomes-Tr:CAB13146" /db_xref="GOA:O34319" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13230" /db_xref="UniProtKB/Swiss-Prot:O34319" /translation="MSRHIQYSIVVPVYNEELVIHETYQRLKEVMDQTKENYELLFVN DGSKDRSIEILREHSLIDPRVKIIDFSRNFGHQIAITAGMDYAQGNAIVVIDADLQDP PELILEMIEKWKEGYEVVYAVRTKRKGETFFKKQTAAMFYRLLSGMTDIDIPIDTGDF RLMDRKVCDEMKRLKEKNPFVRGLVSWVGFKQTAVEYVRDERLAGETKYPLKKMLKLS MDGITTFSHKPLKLASYAGILMSGTGFLYMFIVLYLKLFTDSTITGWSSLIVIQLLFS GIVLLILGVIGEYIGRIYDEAKDRPLYIVQKSYGIENKRLYRDQHMS*" /label="ykcC CDS" gene 1237642..1238613 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /label="ykcC gene" S_feature complement(1237970..1238611) /Source="Nicolas_S_feature" /locus_tag="new_1356775_1357416_c" /HighExp="T-0.40H, T0.0H, Salt, T0.30H, T-1.10H, C30, T-1.40H, S0, H2O2, T1.0H" /AntisenseName="ykcC" /AntisenseCor="9.6017422892053297E-4" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S461" downshifts complement(1238656) /Source="Nicolas_upshifts" /id="D703" /incds=0 /nref=9 /ntot=114 /MaxReadThrough="4.36795" /MaxDrop="4.15844" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=489 /isTUend="FALSE" /label="downshifts" S_feature complement(1238681..1239047) /Source="Nicolas_S_feature" /locus_tag="new_1357486_1357852_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T0.0H, T2.30H, T-0.40H, T3.0H, Salt, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99893799999999999" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S462" downshifts complement(1238724) /Source="Nicolas_upshifts" /id="D704" /incds=0 /nref=17 /ntot=157 /MaxReadThrough="6.61192" /MaxDrop="3.74411" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=421 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1239027..1239042) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1239047) /Source="Nicolas_upshifts" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1239054..1239063) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1239131..1240480) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /EC_number="3.4.21.107" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 11555295, 12823817, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 11555295, 12823817, 24362423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound serine protease Do, quality control protease and chaperone (heat-shock protein)" /protein_id="NP_389173.2" /db_xref="EnsemblGenomes-Gn:BSU12900" /db_xref="EnsemblGenomes-Tr:CAB13147" /db_xref="GOA:O34358" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG12608" /db_xref="UniProtKB/Swiss-Prot:O34358" /translation="MDNYRDENRTKGNENEVFLTKENDQSASYSARNVIHDQEKKKRG FGWFRPLLGGVIGGSLALGIYTFTPLGDHDSQDTAKQSSSQQQTQSVTATSTSSESKK SSSSSSAFKSEDSSKISDMVEDLSPAIVGITNLQAQSNSSLFGSSSSDSSEDTESGSG SGVIFKKENGKAYIITNNHVVEGASSLKVSLYDGTEVTAKLVGSDSLTDLAVLQISDD HVTKVANFGDSSDLRTGETVIAIGDPLGKDLSRTVTQGIVSGVDRTVSMSTSAGETSI NVIQTDAAINPGNSGGPLLNTDGKIVGINSMKISEDDVEGIGFAIPSNDVKPIAEELL SKGQIERPYIGVSMLDLEQVPQNYQEGTLGLFGSQLNKGVYIREVASGSPAEKAGLKA EDIIIGLKGKEIDTGSELRNILYKDAKIGDTVEVKILRNGKEMTKKIKLDQKEEKTS* " /label="htrA CDS" gene complement(1239131..1240480) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /label="htrA gene" downshifts complement(1239145) /Source="Nicolas_upshifts" /id="D705" /incds=0 /nref=198 /ntot=244 /MaxReadThrough="2.95586" /MaxDrop="5.35972" /score="30.7234179" /energy="-19.9" /TU="NA" /idTUdmin="U1044" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1240520..1240527 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-35" promotor_-10 complement(1240532..1240551) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1240540 /Source="Nicolas_upshifts" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="upshifts" promotor_-10 1240542..1240561 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-10" upshifts complement(1240550) /Source="Nicolas_upshifts" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1240552..1240634) /Source="Nicolas_S_feature" /locus_tag="new_1359357_1359439_c" /HighExp="Etha, dia5, S8, S6, T2.0H, T3.30H, dia15, T5.0H, BC, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.682" /TUlongSig="NA" /TUlongPSig="NA" /label="S463" promotor_-35 complement(1240562..1240569) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1240591..1240597 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1240612..1240631 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1240615 /Source="Nicolas_upshifts" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1240617..1240636) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1240634) /Source="Nicolas_upshifts" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1240649..1241467 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /EC_number="1.5.1.2" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redundant pyrroline-5-carboxylate reductase" /protein_id="NP_389174.1" /db_xref="EnsemblGenomes-Gn:BSU12910" /db_xref="EnsemblGenomes-Tr:CAB13148" /db_xref="GOA:Q00777" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10841" /db_xref="UniProtKB/Swiss-Prot:Q00777" /translation="MEQIGLIGYGSMADMIARQLLKHEQIKENELFIETRTKGERLRA LMSDYPNVSADPLENWANTCQLILICVPPLHVIETMRRLYPYVNRNTHIVSIAAGVPL RLLEAETEAGISRVIPAITSEAEAGISLVVHSEALAAEKKERLNELLSVFSRVREIKE SNLDVASNLTSSAPGFIAAIFEELALSAVRNSSLSKEEAFDFLIHSLYGTGKMLIEKN MSFEETLERVATKGGITGEGAEVIHASVPDVFDEVFERTLRKYELLTEQVGKQT*" /label="proCC CDS" gene 1240649..1241467 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /label="proCC gene" promotor_-35 complement(1240652..1240655) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1241445 /Source="Nicolas_upshifts" /id="D706" /incds=0 /nref=90 /ntot=220 /MaxReadThrough="1.3818" /MaxDrop="4.43155" /score="-5.08770006" /energy="-5.3" /TU="NA" /idTUdmin="U1045" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1241524..1241531 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1241546..1241565 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1241550 /Source="Nicolas_upshifts" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="upshifts" CDS 1241596..1242420 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11069674, 11473256, 19340926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069674, 11473256, 19340926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-aminopeptidase" /protein_id="NP_389175.2" /db_xref="EnsemblGenomes-Gn:BSU12920" /db_xref="EnsemblGenomes-Tr:CAB13149" /db_xref="GOA:P26902" /db_xref="InterPro:IPR007035" /db_xref="InterPro:IPR027476" /db_xref="InterPro:IPR033824" /db_xref="InterPro:IPR036177" /db_xref="PDB:1HI9" /db_xref="SubtiList:BG10842" /db_xref="UniProtKB/Swiss-Prot:P26902" /translation="MKLYMSVDMEGISGLPDDTFVDSGKRNYERGRLIMTEEANYCIA EAFNSGCTEVLVNDSHSKMNNLMVEKLHPEADLISGDVKPFSMVEGLDDTFRGALFLG YHARASTPGVMSHSMIFGVRHFYINDRPVGELGLNAYVAGYYDVPVLMVAGDDRAAKE AEELIPNVTTAAVKQTISRSAVKCLSPAKAGRLLTEKTAFALQNKDKVKPLTPPDRPV LSIEFANYGQAEWANLMPGTEIKTGTTTVQFQAKDMLEAYQAMLVMTELAMRTSFC*" /label="dppA CDS" gene 1241596..1242420 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /label="dppA gene" CDS 1242437..1243363 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389176.1" /db_xref="EnsemblGenomes-Gn:BSU12930" /db_xref="EnsemblGenomes-Tr:CAB13150" /db_xref="GOA:P26903" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10843" /db_xref="UniProtKB/Swiss-Prot:P26903" /translation="MARYMIKRFWAMAATILVITTLTFVLMKVIPGSPFNEERGTNEA VQKNLEAYYHLDDPLIFQYIFYLKSIITFDFGPSIKKPSDSVNDMLERGFPVSFELGM TAIVIAVISGLVLGVIAALRRNGFLDYAAMSLAVLGISIPNFILATLLIQQFAVNLKL FPAATWTSPIHMVLPTAALAVGPMAIIARLTRSSMVEVLTQDYIRTAKAKGLSPFKII VKHALRNALMPVITVLGTLVASILTGSFVIEKIFAIPGMGKYFVESINQRDYPVIMGT TVFYSVILIIMLFLVDLAYGLLDPRIKLHKKG*" /label="dppB CDS" gene 1242437..1243363 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /label="dppB gene" CDS 1243369..1244331 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389177.1" /db_xref="EnsemblGenomes-Gn:BSU12940" /db_xref="EnsemblGenomes-Tr:CAB13151" /db_xref="GOA:P26904" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10844" /db_xref="UniProtKB/Swiss-Prot:P26904" /translation="MNLPVQTDERQPEQHNQVPDEWFVLNQEKNREADSVKRPSLSYT QDAWRRLKKNKLAMAGLFILLFLFVMAVIGPFLSPHSVVRQSLTEQNLPPSADHWFGT DELGRDVFTRTWYGARISLFVGVMAALIDFLIGVIYGGVAGYKGGRIDSIMMRIIEVL YGLPYLLVVILLMVLMGPGLGTIIVALTVTGWVGMARIVRGQVLQIKNYEYVLASKTF GAKTFRIIRKNLLPNTMGAIIVQMTLTVPAAIFAESFLSFLGLGIQAPFASWGVMAND GLPTILSGHWWRLFFPAFFISLTMYAFNVLGDGLQDALDPKLRR*" /label="dppC CDS" gene 1243369..1244331 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /label="dppC gene" promotor_-35 1244063..1244068 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1244084..1244102 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1244085 /Source="Nicolas_upshifts" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="upshifts" CDS 1244336..1245343 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7536291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7536291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (ATP-binding subunit)" /protein_id="NP_389178.1" /db_xref="EnsemblGenomes-Gn:BSU12950" /db_xref="EnsemblGenomes-Tr:CAB13152" /db_xref="GOA:P26905" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10845" /db_xref="UniProtKB/Swiss-Prot:P26905" /translation="MEKVLSVQNLHVSFTTYGGTVQAVRGVSFDLYKGETFAIVGESG CGKSVTSQSIMGLLPPYSAKVTDGRILFKNKDLCRLSDKEMRGIRGADISMIFQDPMT ALNPTLTVGDQLGEALLRHKKMSKKAARKEVLSMLSLVGIPDPGERLKQYPHQFSGGM RQRIVIAMALICEPDILIADEPTTALDVTIQAQILELFKEIQRKTDVSVILITHDLGV VAQVADRVAVMYAGKMAEIGTRKDIFYQPQHPYTKGLLGSVPRLDLNGAELTPIDGTP PDLFSPPPGCPFAARCPNRMVVCDRVYPGQTIRSDSHTVNCWLQDQRAEHAVLSGDAK D*" /label="dppD CDS" gene 1244336..1245343 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /label="dppD gene" CDS 1245346..1246995 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7783641, 8793880, 11390694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783641, 8793880, 11390694; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (dipeptide-binding lipoprotein)" /protein_id="NP_389179.2" /db_xref="EnsemblGenomes-Gn:BSU12960" /db_xref="EnsemblGenomes-Tr:CAB13153" /db_xref="GOA:P26906" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10846" /db_xref="UniProtKB/Swiss-Prot:P26906" /translation="MKRGKRMKRVKKLWGMGLALGLSFALMGCTANEQAGKEGSHDKA KTSGEKVLYVNNENEPTSFDPPIGFNNVSWQPLNNIMEGLTRLGKDHEPEPAMAEKWS VSKDNKTYTFTIRENAKWTNGDPVTAGDFEYAWKRMLDPKKGASSAFLGYFIEGGEAY NSGKGKKDDVKVTAKDDRTLEVTLEAPQKYFLSVVSNPAYFPVNEKVDKDNPKWFAES DTFVGNGPFKLTEWKHDDSITMEKSDTYWDKDTVKLDKVKWAMVSDRNTDYQMFQSGE LDTAYVPAELSDQLLDQDNVNIVDQAGLYFYRFNVNMEPFQNENIRKAFAMAVDQEEI VKYVTKNNEKPAHAFVSPGFTQPDGKDFREAGGDLIKPNESKAKQLLEKGMKEENYNK LPAITLTYSTKPEHKKIAEAIQQKLKNSLGVDVKLANMEWNVFLEDQKALKFQFSQSS FLPDYADPISFLEAFQTGNSMNRTGWANKEYDQLIKQAKNEADEKTRFSLMHQAEELL INEAPIIPVYFYNQVHLQNEQVKGIVRHPVGYIDLKWADKN*" /label="dppE CDS" gene 1245346..1246995 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /label="dppE gene" downshifts 1246989 /Source="Nicolas_upshifts" /id="D707" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="6.73127" /MaxDrop="3.5888" /score="22.838155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-4469" /isTUend="FALSE" /label="downshifts" CDS 1247083..1248042 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /EC_number="3.4.17.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10428950, 15101989, 18535144, 20944232, 24123814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="muropeptide L,D-carboxypeptidase" /protein_id="NP_389180.2" /db_xref="EnsemblGenomes-Gn:BSU12970" /db_xref="EnsemblGenomes-Tr:CAB13154" /db_xref="GOA:O34851" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13231" /db_xref="UniProtKB/Swiss-Prot:O34851" /translation="MKGVFSLNYKPKALNKGDTVGVIAPASPPDPKKLDTALLFLEEL GLQVKLGKALKNQHGYLAGQDDERLADLHEMFRDDEVKAVLCACGGFGTGRIAAGIDF SLIRKHPKIFWGYSDITFLHTAIHQNTGLVTFHGPMLSTDIGLDDVHPLTKASYKQLF QETEFTYTEELSPLTELVPGKAEGELVGGNLSLLTSTLGTPFEIDTRGKLLFIEDIDE EPYQIDRMLNQLKMGGKLTDAAGILVCDFHNCVPVKREKSLSLEQVLEDYIISAGRPA LRGFKIGHCSPSIAVPIGAKAAMNTAEKTAVIEAGVSEGALKT*" /label="ldcA CDS" gene 1247083..1248042 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /label="ldcA gene" CDS 1248039..1249139 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /EC_number="5.1.1.20" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11747447, 11747448, 15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11747447, 11747448, 15101989; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-Ala-D/L-Glu epimerase" /protein_id="NP_389181.1" /db_xref="EnsemblGenomes-Gn:BSU12980" /db_xref="EnsemblGenomes-Tr:CAB13155" /db_xref="GOA:O34508" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:1JPM" /db_xref="PDB:1TKK" /db_xref="SubtiList:BG13232" /db_xref="UniProtKB/Swiss-Prot:O34508" /translation="MKIIRIETSRIAVPLTKPFKTALRTVYTAESVIVRITYDSGAVG WGEAPPTLVITGDSMDSIESAIHHVLKPALLGKSLAGYEAILHDIQHLLTGNMSAKAA VEMALYDGWAQMCGLPLYQMLGGYRDTLETDYTVSVNSPEEMAADAENYLKQGFQTLK IKVGKDDIATDIARIQEIRKRVGSAVKLRLDANQGWRPKEAVTAIRKMEDAGLGIELV EQPVHKDDLAGLKKVTDATDTPIMADESVFTPRQAFEVLQTRSADLINIKLMKAGGIS GAEKINAMAEACGVECMVGSMIETKLGITAAAHFAASKRNITRFDFDAPLMLKTDVFN GGITYSGSTISMPGKPGLGIIGAALLKGEKEQ*" /label="aeeB CDS" gene 1248039..1249139 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /label="aeeB gene" CDS 1249136..1250026 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989, 20944232" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 20944232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamyl-L-diaminoacid endopeptidase" /protein_id="NP_389182.2" /db_xref="EnsemblGenomes-Gn:BSU12990" /db_xref="EnsemblGenomes-Tr:CAB13156" /db_xref="GOA:O35010" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG13233" /db_xref="UniProtKB/Swiss-Prot:O35010" /translation="MMHTVISAVANIWTAPDSPRPSDQFMLQPTVMIRDWLERMTYDE RLGLCTDNVIQTQVLFGEKVLVTAEQGEWVSVIVPSQPSRKDPRGYPGWMKKYQLEKT KPIHTQHDVMISKPAAFLYRSNGEKEIELSFLTVLPLIAKENGYFKVSTVFGERFVRQ SDAVPVSQQKGTAEDIIQTGAFFLGLPYLWGGISGFGFDCSGFMYSIFKANGYSIPRD AGDQAKAGKGVPLDDMKAGDLLFFAYEEGKGAIHHVGLYVGGGKMLHSPKTGKSIEIL TLTETIYEKELCAVRRCFSE*" /label="eepC CDS" gene 1249136..1250026 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /label="eepC gene" CDS 1250039..1251028 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cell wall oligopeptide ABC transporter (ATP binding protein)" /protein_id="NP_389183.2" /db_xref="EnsemblGenomes-Gn:BSU13000" /db_xref="EnsemblGenomes-Tr:CAB13157" /db_xref="GOA:C0SP98" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13234" /db_xref="UniProtKB/Swiss-Prot:C0SP98" /translation="MRRLPLLEVSQLKMHFDAGKKRTVKAVDGVTFQIREGETFGLVG ESGCGKSTLGRVLMRLYQPTEGSVTYRGTNLHALSEKEQFAFNRKLQMIFQDPYASLN PRMTVREIILEPMEIHNLYNTHKARLLVVDELLEAVGLHPDFGSRYPHEFSGGQRQRI GIARALSLNPEFIVADEPISALDVSVQAQVVNLLKRLQKEKGLTFLFIAHDLSMVKHI SDRIGVMYLGHMMEITESGTLYREPLHPYTKALLSSIPIPDPELEDKRERILLKGELP SPVNPPSGCVFRTRCPEAMPECGESRPQLQEIEPGRFVACHLYRNAETKEKVR*" /label="ykfD CDS" gene 1250039..1251028 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /label="ykfD gene" S_feature complement(1250322..1251049) /Source="Nicolas_S_feature" /locus_tag="new_1369127_1369854_c" /HighExp="Etha, S7, Gly, M40t90, C30, H2O2, M0t90, dia15, T1.0H, S8" /AntisenseName="ykfD" /AntisenseCor="-6.3474114158352593E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S464" downshifts 1251018 /Source="Nicolas_upshifts" /id="D708" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="5.08319" /MaxDrop="3.1399" /score="-3.10371155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" S_feature 1251063..1252231 /Source="Nicolas_S_feature" /locus_tag="new_1369868_1371036" /HighExp="T3.30H, T4.0H, T3.0H, T5.0H, T2.30H, T2.0H, S1, M9-stat, T1.30H, HiOs" /AntisenseName="ykgB" /AntisenseCor="-0.33524952291190102" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S465" CDS complement(1251071..1252120) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /EC_number="3.1.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22960854, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconolactonase" /protein_id="NP_389184.1" /db_xref="EnsemblGenomes-Gn:BSU13010" /db_xref="EnsemblGenomes-Tr:CAB13158" /db_xref="GOA:O34499" /db_xref="InterPro:IPR011048" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019405" /db_xref="SubtiList:BG13236" /db_xref="UniProtKB/Swiss-Prot:O34499" /translation="MTKYIGYVGTYTKGGSEGIYSFELDTEKKALSEPKLAAKLGNPT YVATNKNNTILYSIEKADGQGGVAAYQIDKNSGELTFLNHQLIDGPSPCHVSVDDQNQ FVLTANYHSGKVHVFPVQEDGSLQSPVSEAAHTGKGPHERQEKPHTHYAGFTPEHNYV VAVDLGIDKLYTYKLKDGVLTESGSHSFAPGAGPRHIAFHPKEKYAYVMTELSNEVIA LEYNPTAGEFREIQVVSAIPDDFTDNSQGSAIHVTQDGRFVYVANRGHDSIAVFEVNQ YSGELAFVERVSTEGNWPRDFVFDPTEGFLVASNEETGNLVLFERDKETGRLTLLPST VSVPYPVCVKFLHQV*" /label="pgl CDS" gene complement(1251071..1252120) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /label="pgl gene" downshifts complement(1251094) /Source="Nicolas_upshifts" /id="D709" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="5.12776" /MaxDrop="6.0668" /score="24.6986564" /energy="-15.6" /TU="U1050" /idTUdmin="U1049" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1252147..1252166) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1252158) /Source="Nicolas_upshifts" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1252181..1252188) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1252210..1253070) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /EC_number="3.5.3.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27258038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N(G),N(G)-dimethylarginine dimethylaminohydrolase" /protein_id="NP_389185.2" /db_xref="EnsemblGenomes-Gn:BSU13020" /db_xref="EnsemblGenomes-Tr:CAB13159" /db_xref="GOA:O34497" /db_xref="InterPro:IPR033199" /db_xref="SubtiList:BG13235" /db_xref="UniProtKB/Swiss-Prot:O34497" /translation="MDVSIPKSQHKTVCRTEYGTLQKVILCKPEHMTIKDVINETQKH FEDDNIHVKTANDQHSRLVEALRSHNVEVVLLPVRDGLPEQVFTRDIGFVIGEKAFLS SMTEPIRQGEEAVIKDFFHSQGISYTRMLDTSIEGGDVIIDDDIVYVGISQRTDISAI GQLEEALPEYTIVPVKLHEKFLHLDCVFNIISESEALIYSQAIEPDAADMLAKRYDLI EVPEDEQFTLGTNVLSIGKKTIISLPGNRHVNQQLSKRGYHIIEIDLSEIIKSGGSFR CCTMPLIRGE*" /label="ddaH CDS" gene complement(1252210..1253070) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /label="ddaH gene" promotor_-10 complement(1253095..1253113) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1253112) /Source="Nicolas_upshifts" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1253129..1253135) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1253144..1253151 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1253165..1253184 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1253172 /Source="Nicolas_upshifts" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="upshifts" CDS 1253230..1253748 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /EC_number="3.1.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12426338, 18247525, 24623648, 24722906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acyl-CoA thioesterase" /protein_id="NP_389186.2" /db_xref="EnsemblGenomes-Gn:BSU13030" /db_xref="EnsemblGenomes-Tr:CAB13160" /db_xref="GOA:P49851" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR033120" /db_xref="SubtiList:BG11417" /db_xref="UniProtKB/Swiss-Prot:P49851" /translation="METPETRFCKESKVVKTSRVFPLDTNNHNTLFGGKLMSYIDDIA SISAARHCRRETVTASMDSVDFLKPIGQKDSVCLESYVTWVGTSSMEVFVKVIKEHLM TGERELAATSFLTFVALDSNGKPVPVPRVVPETEEEIMLHNTAVQRANERKNRKRHSQ ALANALGTDKPW*" /label="ykhA CDS" gene 1253230..1253748 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /label="ykhA gene" downshifts 1253739 /Source="Nicolas_upshifts" /id="D710" /incds=0 /nref=34 /ntot=265 /MaxReadThrough="4.66856" /MaxDrop="4.77681" /score="24.0889455" /energy="-10.9" /TU="U1051" /idTUdmin="U1051" /TUdmin="-1436" /isTUend="FALSE" /label="downshifts" promotor_-35 1253813..1253819 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-35" S_feature 1253831..1253937 /Source="Nicolas_S_feature" /locus_tag="new_1372636_1372742" /HighExp="Etha, S5, S6, S8, nit, S7, ferm, S4, dia15, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S466" upshifts 1253831 /Source="Nicolas_upshifts" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="upshifts" promotor_-10 1253833..1253844 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-10" promotor_-35 1253912..1253915 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1253931..1253950 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1253939 /Source="Nicolas_upshifts" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="upshifts" CDS 1253987..1255186 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044; Product type c: carrier" /codon_start=1 /transl_table=11 /product="flavohemoglobin" /protein_id="NP_389187.1" /db_xref="EnsemblGenomes-Gn:BSU13040" /db_xref="EnsemblGenomes-Tr:CAB13161" /db_xref="GOA:P49852" /db_xref="InterPro:IPR000971" /db_xref="InterPro:IPR001221" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR008333" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023950" /db_xref="SubtiList:BG11418" /db_xref="UniProtKB/Swiss-Prot:P49852" /translation="MLDNKTIEIIKSTVPVLQQHGETITGRFYDRMFQDHPELLNIFN QTNQKKKTQRTALANAVIAAAANIDQLGNIIPVVKQIGHKHRSIGIKPEHYPIVGKYL LIAIKDVLGDAATPDIMQAWEKAYGVIADAFIGIEKDMYEQAEEQAGGWKEYKPFVIA KKERESKEITSFYLKPEDSKPLPEFQAGQYISIKVRIPDSEYTHIRQYSLSDMPGKDY YRISVKKDGVVSSYLHDGLQEGDSIEISAPAGDFVLDHASQKDLVLISAGVGITPMIS MLKTSVSKQPERQILFIHAAKNSEYHALRHEVEEAAKHSAVKTAFVYREPTEEDRAGD LHFHEGQIDQQFLKELIANTDADYYICGSPSFITAMHKLVSELGSAPESIHYELFGPQ LSLAQSV*" /label="hmpA CDS" gene 1253987..1255186 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /label="hmpA gene" downshifts 1255175 /Source="Nicolas_upshifts" /id="D711" /incds=0 /nref=10 /ntot=59 /MaxReadThrough="6.06442" /MaxDrop="4.19301" /score="11.2868967" /energy="-9.3" /TU="U1053" /idTUdmin="U1051" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1255220..1255591 /Source="Nicolas_S_feature" /locus_tag="new_1374025_1374396" /HighExp="nit, B36, B60, Etha, BI, M40t90, LBGtran, M0t90, BT, S6" /AntisenseName="ykzH" /AntisenseCor="7.6554747052539299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="SigGF" /TUlongPSig="0.998" /label="S467" CDS complement(1255263..1255487) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389188.1" /db_xref="EnsemblGenomes-Gn:BSU13050" /db_xref="EnsemblGenomes-Tr:CAB13162" /db_xref="SubtiList:BG13336" /db_xref="UniProtKB/Swiss-Prot:O31653" /translation="MKNQKSNTLWPFDLPLAPQPEGYQQQTIDRLAGLELRMKQLIRA IEVNNELLRTMQEQQNRVCTNGSGSVIVRM*" /label="ykzH CDS" gene complement(1255263..1255487) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /label="ykzH gene" promotor_-35 1255567..1255573 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1255587..1255598 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1255593 /Source="Nicolas_upshifts" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="upshifts" CDS 1255632..1256363 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389189.1" /db_xref="EnsemblGenomes-Gn:BSU13060" /db_xref="EnsemblGenomes-Tr:CAB13163" /db_xref="GOA:P49853" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG11419" /db_xref="UniProtKB/Swiss-Prot:P49853" /translation="MLWMVWVFLLKPVIVFSIAYILFRLAGKKAVSQMNNFDLLLTFA IGTIISEPILTSKLPMSIYYAGAFLVLYLIMSKLSLSNKWRWLLVVSPTVLIRNGDID ERGLRKERLTVNELLGKLREKGYADPADIDLAIIEETGEVSVIPKEEARAVQVRDLNM EAERNFIPIPLILDGEILDHNLKYLQKNRSWLFEKLEEKGYSPKLLSSIILGTMNARG DISLDLNTANEPQHDPYLYKPGNNN*" /label="ykjA CDS" gene 1255632..1256363 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /label="ykjA gene" downshifts 1256341 /Source="Nicolas_upshifts" /id="D712" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="2.84532" /MaxDrop="4.44655" /score="17.2468985" /energy="-7.2" /TU="U1053" /idTUdmin="U1054" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1256402..1256410 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1256421..1256439 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1256429 /Source="Nicolas_upshifts" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="upshifts" CDS 1256455..1256982 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389190.1" /db_xref="EnsemblGenomes-Gn:BSU13070" /db_xref="EnsemblGenomes-Tr:CAB13164" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG11420" /db_xref="UniProtKB/Swiss-Prot:P49854" /translation="MKDLSIRNDMAPTVSLLYSAVEENSLRLASIVSHMTHSELYYKG RCQTKNSTAQLLHHITNVDIRWVWRIKENRIPDHIEQAYGPMTDESGRLPEPVNQPDL DELLKRHQHVVEKLKSVCFTLTENALNQPLSFEGDTATIRWGIWHMADHNRYHQAHIE ALKKEWKQDVAKYER*" /label="ykkA CDS" gene 1256455..1256982 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /label="ykkA gene" CDS 1256972..1257490 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389191.1" /db_xref="EnsemblGenomes-Gn:BSU13080" /db_xref="EnsemblGenomes-Tr:CAB13165" /db_xref="GOA:P49855" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11421" /db_xref="UniProtKB/Swiss-Prot:P49855" /translation="MNAKTKLVTDRIRLRCMEDRDQATLFGLLFNDPDVMTYYSGLKD KRQTREWVNWNQRNEKGYGVSLWIAEDKRTGEFLGQCGIVPQQIENQTVMEIGYMFAR RHWGNGYAQEAARACLDYGFNERQFGKMAALIDPGNKASIRVAEKIGMHYSKTIRKWN KPIAVYERKSYN*" /label="ykkB CDS" gene 1256972..1257490 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /label="ykkB gene" promotor_-35 1257484..1257491 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-35" promotor_-10 1257505..1257524 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-10" upshifts 1257508 /Source="Nicolas_upshifts" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="upshifts" misc_RNA 1257523..1257634 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /product="guanidine-sensing riboswitch (binds free guanidinium)" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17908319, 21317561, 27989440, 28001368, 28017522, 28107646, 28212758; Product type n: RNA" /label="gdwA RNA" gene 1257523..1257634 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /label="gdwA gene" downshifts 1257597 /Source="Nicolas_upshifts" /id="D713" /incds=0 /nref=205 /ntot=246 /MaxReadThrough="3.70824" /MaxDrop="6.58389" /score="30.3456563" /energy="-18.5" /TU="U1056" /idTUdmin="U1056" /TUdmin="-789" /isTUend="FALSE" /label="downshifts" CDS 1257712..1258050 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389192.1" /db_xref="EnsemblGenomes-Gn:BSU13090" /db_xref="EnsemblGenomes-Tr:CAB13166" /db_xref="GOA:P49856" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11422" /db_xref="UniProtKB/Swiss-Prot:P49856" /translation="MKWGLVVLAAVFEVVWVIGLKHADSALTWSGTAIGIIFSFYLLM KATHSLPVGTVYAVFTGLGTAGTVLSEIVLFHEPVGWPKLLLIGVLLIGVIGLKLVTQ DETEEKGGEA*" /label="gdnC CDS" gene 1257712..1258050 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /label="gdnC gene" CDS 1258050..1258367 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389193.1" /db_xref="EnsemblGenomes-Gn:BSU13100" /db_xref="EnsemblGenomes-Tr:CAB13167" /db_xref="GOA:P49857" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11423" /db_xref="UniProtKB/Swiss-Prot:P49857" /translation="MLHWISLLCAGCLEMAGVALMNQYAKEKSVKWVLLIIVGFAASF SLLSYAMETTPMGTAYAVWTGIGTAGGALIGILFYKEQKDAKRIFFIALILCSAVGLK ILS*" /label="gdnD CDS" gene 1258050..1258367 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /label="gdnD gene" promotor_-35 1258367..1258370 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1258386..1258405 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1258398 /Source="Nicolas_upshifts" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="upshifts" CDS 1258438..1259340 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /EC_number="3.5.1.10" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8226647, 24108189; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formyltetrahydrofolate hydrolase" /protein_id="NP_389194.2" /db_xref="EnsemblGenomes-Gn:BSU13110" /db_xref="EnsemblGenomes-Tr:CAB13168" /db_xref="GOA:O34990" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004810" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG13237" /db_xref="UniProtKB/Swiss-Prot:O34990" /translation="MKSYMTQRLDEYRDGNEDKGRLLVSCPDQPGIVSAVSAFLFEHG ANIIESNQYTTDPEGGRFFLRIEFDCAGIREKKSSLQAAFASVAEKFDMTWSLTLASE LKRVAIFVSKELHCLHELIWEWQTGNLMAEIAVVISNHEEARELVERLNIPFHYMKAN KDIRAEVEKKQLELLEQYDVDVIVLARYMQILTPDFVSAHPNRIINIHHSFLPAFIGA NPYKRAYERGVKLIGATSHYVTNDLDEGPIIEQDIERVDHRDNAEALKNIGRTIERSV LARAVKWHLEDRVIVHENKTIVFN*" /label="purU CDS" gene 1258438..1259340 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /label="purU gene" downshifts 1259331 /Source="Nicolas_upshifts" /id="D714" /incds=0 /nref=91 /ntot=226 /MaxReadThrough="3.55628" /MaxDrop="5.02155" /score="16.8011006" /energy="-13.1" /TU="U1057" /idTUdmin="U1056" /TUdmin=945 /isTUend="FALSE" /label="downshifts" promotor_-35 1259387..1259393 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1259399 /Source="Nicolas_upshifts" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1259407..1259426 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1259428..1259638 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /product="T-box riboswitch specific of proline tRNA" /experiment="publication(s) with functional evidences, PMID:11917026, 12749771, 19932103, 21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11917026, 12749771, 19932103, 21233158; Product type n: RNA" /function="16.3: Control" /label="pswB RNA" gene 1259428..1259638 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /label="pswB gene" downshifts 1259596 /Source="Nicolas_upshifts" /id="D715" /incds=0 /nref=4 /ntot=52 /MaxReadThrough="6.91996" /MaxDrop="3.8361" /score="29.5878921" /energy="-17.6" /TU="U1057,U1058" /idTUdmin="U1056" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS 1259691..1260788 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /EC_number="2.7.2.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21233158, 21784929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21233158, 21784929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389195.2" /db_xref="EnsemblGenomes-Gn:BSU13120" /db_xref="EnsemblGenomes-Tr:CAB13169" /db_xref="GOA:P39820" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10963" /db_xref="UniProtKB/Swiss-Prot:P39820" /translation="MKKQRIVVKIGSSSLTNSKGSIDEAKIREHVQAISVLKKAGHEM ILITSGAVAAGFSSLGYPSRPVTIKGKQAAAAVGQTLLMQQYMNQFKQYSLTPGQILL TRNDFSKRERYRNAYATIMELLERGVIPIINENDSTSVEELTFGDNDMLSALVSGLIH ADQLMILTDINGLYDANPNENPEAKRFDYLPEITPELLGYAGSAGSKVGTGGMKSKLL ATQTALSLGVKVFIGTGSGEQKLADILDGRGDGTYIGDKELSSVNNTRQWIQFHSPIS GEIIIDAGAEEAMIHNGSSLLPAGVVGVNGSFPKGAVVEVRGPGGVIGKGQTHYSSEE IMEAKGKRSDELDFEKTFEVIHRNDWVNVKD*" /label="proB CDS" gene 1259691..1260788 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /label="proB gene" promotor_-35 1259878..1259880 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1259882..1259886 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1259882 /Source="Nicolas_upshifts" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="upshifts" CDS 1260800..1262047 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /EC_number="1.2.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21784929, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21784929, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-glutamyl phosphate reductase" /protein_id="NP_389196.2" /db_xref="EnsemblGenomes-Gn:BSU13130" /db_xref="EnsemblGenomes-Tr:CAB13170" /db_xref="GOA:P39821" /db_xref="InterPro:IPR000965" /db_xref="InterPro:IPR012134" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR020593" /db_xref="SubtiList:BG10964" /db_xref="UniProtKB/Swiss-Prot:P39821" /translation="MSEVSVKAKLAKEAAAEMIMKTTAEKDEALSLIANGLRKELDFL LAENAKDIVNGKENGLTPDIIDRLSLDEKRIRDIADAVELLIDLADPIGDSLETIEKE NGLFIEKIRVPLGVVGMIYEARPNVTVDAATLCLKTGNAVVLRGSSSAIHSNKALVSV IYRALEQSALPIHAVQLIEDTSRETAKELFTLNDGLDVLIPRGGKKLIDLVVRESTVP VLETGAGNCHIFIDETAKPQMAEKVVVNAKTQRPSVCNAIESLLIHKAWARQHGKELL DQLENAGVEIRGDELVCELHPSSKQASKEDWETEFLAPVLSVKTVENVQEAVKHIQQY GTNHSEAILTENDKNAVYFQTAVDAAAVYHNASTRFTDGFEFGYGAEIGISTQKLHAR GPMGLPALTSTKYIIKGTGQIRE*" /label="proA CDS" gene 1260800..1262047 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /label="proA gene" downshifts 1262038 /Source="Nicolas_upshifts" /id="D716" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="4.1607" /MaxDrop="6.017" /score="11.118012" /energy="-11" /TU="U1058" /idTUdmin="U1059" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1262109..1262116 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1262131..1262150 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1262140 /Source="Nicolas_upshifts" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1262173..1262598 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11418552, 17502599, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418552, 17502599, 21749987, 24184231; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin" /protein_id="NP_389197.1" /db_xref="EnsemblGenomes-Gn:BSU13140" /db_xref="EnsemblGenomes-Tr:CAB13171" /db_xref="GOA:O34762" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13238" /db_xref="UniProtKB/Swiss-Prot:O34762" /translation="MSQPLFTATVSAVGGREGKVISSDRVLELDVAMPGTPRAKKLEK ATNPEQLFAAGYAACFDSALQLVARTERVKVETEVTANVSLLKDEADQGYKLGVTLQV KGEGVSASELEALVKKAHGVCPYSKATSGNIDVTLEVAE*" /label="ohrA CDS" gene 1262173..1262598 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /label="ohrA gene" downshifts 1262587 /Source="Nicolas_upshifts" /id="D717" /incds=0 /nref=57 /ntot=174 /MaxReadThrough="0.0429100000000009" /MaxDrop="3.90314" /score="30.9245751" /energy="-16.6" /TU="NA" /idTUdmin="U1060" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1262629..1263072) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11983871, 17502599, 18363800, 20094649, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11983871, 17502599, 18363800, 20094649, 21749987, 24184231; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator sensing organic peroxides" /protein_id="NP_389198.1" /db_xref="EnsemblGenomes-Gn:BSU13150" /db_xref="EnsemblGenomes-Tr:CAB13172" /db_xref="GOA:O34777" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1Z91" /db_xref="PDB:1Z9C" /db_xref="SubtiList:BG13239" /db_xref="UniProtKB/Swiss-Prot:O34777" /translation="MENKFDHMKLENQLCFLLYASSREMTKQYKPLLDKLNITYPQYL ALLLLWEHETLTVKKMGEQLYLDSGTLTPMLKRMEQQGLITRKRSEEDERSVLISLTE DGALLKEKAVDIPGTILGLSKQSGEDLKQLKSALYTLLETLHQKN*" /label="ohrR CDS" gene complement(1262629..1263072) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /label="ohrR gene" downshifts complement(1262663) /Source="Nicolas_upshifts" /id="D718" /incds=0 /nref=105 /ntot=232 /MaxReadThrough="-0.17111" /MaxDrop="4.73026" /score="34.7008532" /energy="-16.6" /TU="NA" /idTUdmin="U1061" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1263099..1263118) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1263105) /Source="Nicolas_upshifts" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1263133..1263136) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1263154..1263160 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1263174..1263192 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1263180 /Source="Nicolas_upshifts" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="upshifts" CDS 1263215..1263625 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9696771, 11418552, 18084074" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696771, 11418552, 18084074; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="organic hydroperoxide resistance reductase B" /protein_id="NP_389199.1" /db_xref="EnsemblGenomes-Gn:BSU13160" /db_xref="EnsemblGenomes-Tr:CAB13173" /db_xref="GOA:P80242" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="PDB:2BJO" /db_xref="SubtiList:BG19021" /db_xref="UniProtKB/Swiss-Prot:P80242" /translation="MALFTAKVTARGGRAGHITSDDGVLDFDIVMPNAKKEGQTGTNP EQLFAAGYAACFGGALEHVAKEQNIEIDSEIEGQVSLMKDESDGGFKIGVTLVVNTKD LDREKAQELVNAAHEFCPYSKATRGNVDVKLELK*" /label="ohrB CDS" gene 1263215..1263625 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /label="ohrB gene" downshifts 1263603 /Source="Nicolas_upshifts" /id="D719" /incds=0 /nref=7 /ntot=145 /MaxReadThrough="8.17185" /MaxDrop="4.0663" /score="17.6512157" /energy="-12.1" /TU="U1062" /idTUdmin="U1062" /TUdmin="-855" /isTUend="FALSE" /label="downshifts" CDS 1263652..1263822 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097717.1" /db_xref="EnsemblGenomes-Gn:BSU13169" /db_xref="EnsemblGenomes-Tr:CAX52607" /db_xref="UniProtKB/Swiss-Prot:C0H400" /translation="MFFGVGHAGRAQIYDKTSEKRLKHAFKPKVTDEAGGWHGVCRAE LRVYAVLYLHRA*" /label="ykzN CDS" gene 1263652..1263822 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /label="ykzN gene" S_feature 1263823..1264500 /Source="Nicolas_S_feature" /locus_tag="new_1382628_1383305" /HighExp="Etha, Salt, M9-stat, Sw, B60, LPhT, B36, Heat, Gly, BC" /AntisenseName="guaD" /AntisenseCor="-5.7732597431508298E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S468" CDS complement(1263872..1264342) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /EC_number="3.5.4.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11101664, 15180998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101664, 15180998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanine deaminase" /protein_id="NP_389200.1" /db_xref="EnsemblGenomes-Gn:BSU13170" /db_xref="EnsemblGenomes-Tr:CAB13174" /db_xref="GOA:O34598" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1TIY" /db_xref="PDB:1WKQ" /db_xref="SubtiList:BG13240" /db_xref="UniProtKB/Swiss-Prot:O34598" /translation="MNHETFLKRAVTLACEGVNAGIGGPFGAVIVKDGAIIAEGQNNV TTSNDPTAHAEVTAIRKACKVLGAYQLDDCILYTSCEPCPMCLGAIYWARPKAVFYAA EHTDAAEAGFDDSFIYKEIDKPAEERTIPFYQVTLTEHLSPFQAWRNFANKKEY*" /label="guaN CDS" gene complement(1263872..1264342) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /label="guaN gene" downshifts complement(1263896) /Source="Nicolas_upshifts" /id="D720" /incds=0 /nref=25 /ntot=112 /MaxReadThrough="0.698199999999999" /MaxDrop="4.30578" /score="-6.41557266" /energy="-13.5" /TU="NA" /idTUdmin="U1063" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1264364..1264383) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1264380) /Source="Nicolas_upshifts" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1264382..1264489) /Source="Nicolas_S_feature" /locus_tag="new_1383187_1383294_c" /HighExp="BMM, MG 10, MG 15, MG 5, MG t5, GM 25, B36, Gly, B60, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.044, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S469" promotor_-35 complement(1264399..1264402) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1264458 /Source="Nicolas_upshifts" /id="D721" /incds=0 /nref=9 /ntot=34 /MaxReadThrough="0.95942" /MaxDrop="5.95076" /score="15.2916843" /energy="-11.5" /TU="NA" /idTUdmin="U1062" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1264515..1266803) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /EC_number="2.1.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cobalamin-independent methionine synthase" /protein_id="NP_389201.2" /db_xref="EnsemblGenomes-Gn:BSU13180" /db_xref="EnsemblGenomes-Tr:CAB13175" /db_xref="GOA:P80877" /db_xref="InterPro:IPR002629" /db_xref="InterPro:IPR006276" /db_xref="InterPro:IPR013215" /db_xref="SubtiList:BG12616" /db_xref="UniProtKB/Swiss-Prot:P80877" /translation="MTTIKTSNLGFPRIGLNREWKKALEAYWKGSTDKDTFLKQIDEL FLSAVKTQIDQQIDVVPVSDFTQYDHVLDTAVSFNWIPKRFRHLTDATDTYFAIARGI KDAVSSEMTKWFNTNYHYIVPEYDESIEFRLTRNKQLEDYRRIKQEYGVETKPVIVGP YTFVTLAKGYEPSEAKAIQKRLVPLYVQLLKELEEEGVKWVQIDEPALVTASSEDVRG AKELFESITSELSSLNVLLQTYFDSVDAYEELISYPVQGIGLDFVHDKGRNLEQLKTH GFPTDKVLAAGVIDGRNIWKADLEERLDAVLDILSIAKVDELWIQPSSSLLHVPVAKH PDEHLEKDLLNGLSYAKEKLAELTALKEGLVSGKAAISEEIQQAKADIQALKQFATGA NSEQKKELEQLTDKDFKRPIPFEERLALQNESLGLPLLPTTTIGSFPQSAEVRSARQK WRKAEWSDEQYQNFINAETKRWIDIQEELELDVLVHGEFERTDMVEYFGEKLAGFAFT KYAWVQSYGSRCVRPPVIYGDVEFIEPMTVKDTVYAQSLTSKHVKGMLTGPVTILNWS FPRNDISRKEIAFQIGLALRKEVKALEDAGIQIIQVDEPALREGLPLKTRDWDEYLTW AAEAFRLTTSSVKNETQIHTHMCYSNFEDIVDTINDLDADVITIEHSRSHGGFLDYLK NHPYLKGLGLGVYDIHSPRVPSTEEMYNIIVDALAVCPTDRFWVNPDCGLKTRQQEET VAALKNMVEAAKQARAQQTQLV*" /label="metE CDS" gene complement(1264515..1266803) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /label="metE gene" downshifts complement(1264534) /Source="Nicolas_upshifts" /id="D722" /incds=0 /nref=212 /ntot=239 /MaxReadThrough="5.25958" /MaxDrop="7.50935" /score="29.3354648" /energy="-11.5" /TU="U1064,U1065" /idTUdmin="U1063" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" S_feature complement(1266804..1266866) /Source="Nicolas_S_feature" /locus_tag="new_1385609_1385671_c" /HighExp="MG 15, MG 5, MG t5, BMM, T-1.40H, MG 25, MG 10, GM 25, Mal, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.044, 1, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S470" promotor_no_box complement(1266826..1266926) /Source="Nicolas_upshift_promotors" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1266866) /Source="Nicolas_upshifts" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(1266931..1267086) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762, 22543867" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762, 22543867; Product type n : RNA" /function="16.3: Control" /label="mswB RNA" gene complement(1266931..1267086) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /label="mswB gene" downshifts complement(1266932) /Source="Nicolas_upshifts" /id="D723" /incds=0 /nref=55 /ntot=106 /MaxReadThrough="8.12248" /MaxDrop="6.4813" /score="24.0596293" /energy="-16.2" /TU="U1065,U1066" /idTUdmin="U1066" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1267119..1267138) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1267131) /Source="Nicolas_upshifts" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1267133..1267218) /Source="Nicolas_S_feature" /locus_tag="new_1385938_1386023_c" /HighExp="BT, BC, B36, M9-stat, T5.0H, S3, S6, T4.0H, S5, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S471" promotor_-35 complement(1267154..1267161) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1267219..1268178) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /EC_number="3.4.21.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3087947, 14680823, 23569278" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3087947, 14680823, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="intracellular serine protease" /protein_id="NP_389202.1" /db_xref="EnsemblGenomes-Gn:BSU13190" /db_xref="EnsemblGenomes-Tr:CAB13176" /db_xref="GOA:P11018" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG10674" /db_xref="UniProtKB/Swiss-Prot:P11018" /translation="MNGEIRLIPYVTNEQIMDVNELPEGIKVIKAPEMWAKGVKGKNI KVAVLDTGCDTSHPDLKNQIIGGKNFTDDDGGKEDAISDYNGHGTHVAGTIAANDSNG GIAGVAPEASLLIVKVLGGENGSGQYEWIINGINYAVEQKVDIISMSLGGPSDVPELK EAVKNAVKNGVLVVCAAGNEGDGDERTEELSYPAAYNEVIAVGSVSVARELSEFSNAN KEIDLVAPGENILSTLPNKKYGKLTGTSMAAPHVSGALALIKSYEEESFQRKLSESEV FAQLIRRTLPLDIAKTLAGNGFLYLTAPDELAEKAEQSHLLTL*" /label="ispA CDS" gene complement(1267219..1268178) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /label="ispA gene" S_feature complement(1268179..1268230) /Source="Nicolas_S_feature" /locus_tag="new_1386984_1387035_c" /HighExp="BT, B36, BC, T5.0H, M9-stat, T0.30H, T3.30H, T3.0H, T4.0H, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S472" promotor_-10 complement(1268223..1268242) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1268235) /Source="Nicolas_upshifts" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1268256..1268262) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1268347..1268350 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1268363 /Source="Nicolas_upshifts" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1268366..1268385 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1268401..1269234 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_389203.1" /db_xref="EnsemblGenomes-Gn:BSU13200" /db_xref="EnsemblGenomes-Tr:CAB13177" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12609" /db_xref="UniProtKB/Swiss-Prot:O34860" /translation="MKLNEKLYAFFSEHVEQMAEEWIETMEESDPNSLYALHNATVTE ELKEQDREFYRHLNYMYVLPEKQFLEEFQEWVIELTNDQKHLDTPVQYVIREFMRNRR LYTKYFEKFAEENESAFEPGEKQKWADLIVKVFDFTIYTFVDHAEMNAKQQLNAQREM ILELSSPVITLSKSTALLPLVGDIDTERAKFILENTLQACAKRRVEHLLIDLSGVVVV DTMVAHQIFKLIEALNLIGVRSTLSGIRPEIAQTAVQLGIDFSNITIKTNLAQALNYH Q*" /label="rsbRB CDS" gene 1268401..1269234 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /label="rsbRB gene" downshifts 1269210 /Source="Nicolas_upshifts" /id="D724" /incds=0 /nref=219 /ntot=254 /MaxReadThrough="3.01586" /MaxDrop="6.07238" /score="22.2655638" /energy="-12.1" /TU="NA" /idTUdmin="U1067" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1269265..1270029) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, transmembrane T component" /protein_id="NP_389204.1" /db_xref="EnsemblGenomes-Gn:BSU13210" /db_xref="EnsemblGenomes-Tr:CAB13178" /db_xref="GOA:O34572" /db_xref="InterPro:IPR003339" /db_xref="SubtiList:BG13248" /db_xref="UniProtKB/Swiss-Prot:O34572" /translation="MKQPLHLINPTVKAAAVFCCVVMLSFIYNPYTPACFYIIIVAGV LLAAGIPLKKWLLFTIPFLILAFGCVWTAAVFGKVPTTPDNFLFQAGPISINSDNVSV GISLGFRILCFSALSMMFVFTTDPILFMLSLVQQCRLSPKLAYGVIAGFRFLPLLKDE VQLIQQAHKIRGGAAESGIINKISALKRYTIPLLASAIRKAERTALAMESKGFTGSRN RTYYRTLSVNRRDWVFFCLVLLLFAGSFLVSLCFAS*" /label="thiX CDS" gene complement(1269265..1270029) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /label="thiX gene" downshifts complement(1269286) /Source="Nicolas_upshifts" /id="D725" /incds=0 /nref=143 /ntot=164 /MaxReadThrough="0.824010000000001" /MaxDrop="6.67697" /score="34.7739353" /energy="-12.1" /TU="NA" /idTUdmin="U1069" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1270004..1271647) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine ABC transporter (ATP-binding subunit)" /protein_id="NP_389205.2" /db_xref="EnsemblGenomes-Gn:BSU13220" /db_xref="EnsemblGenomes-Tr:CAB13179" /db_xref="GOA:O34362" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13249" /db_xref="UniProtKB/Swiss-Prot:O34362" /translation="MQAFDELLTVEQLSFSYEEDEKPVFQDISFELQKGECVLLLGPS GCGKSSLALCLNGLYPEACDGIQSGHVFLFQKPVTDAETSETITQHAGVVFQDPDQQF CMLTVEDEIAFGLENLQIPKEEMTEKINAVLEKLRITHLKEKMISTLSGGQKQKVALA CILAMEPELIILDEPTSLLDPFSAREFVHLMKDLQREKGFSLLVIEHQLDEWAPWIER TIVLDKSGKKALDGLTKNLFQHEAETLKKLGIAIPKVCHLQEKLSMPFTLSKEMLFKE PIPAGHVKKKKAPSGESVLEVSSLSFARGQQAIFKDISFSLREGSLTALVGPNGTGKS TLLSVLASLMKPQSGKILLYDQPLQKYKEKELRKRMGFVFQNPEHQFVTDTVYDELLF GQKANAETEKKAQHLLQRFGLAHLADHHPFAISQGQKRRLSVATMLMHDVKVLLLDEP TFGQDARTAAECMEMIQRIKAEGTAVLMITHDMELVSSYADSVLVLHDTGLAFDGSPA QLFSQETGLVQKAKLTLPLLYEWMAFQEEVRDEATVTSH*" /label="thiW CDS" gene complement(1270004..1271647) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /label="thiW gene" CDS complement(1271634..1272233) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 27447050, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 27447050, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, permease component" /protein_id="NP_389206.2" /db_xref="EnsemblGenomes-Gn:BSU13230" /db_xref="EnsemblGenomes-Tr:CAB13180" /db_xref="GOA:O34738" /db_xref="InterPro:IPR017195" /db_xref="PDB:5EDL" /db_xref="SubtiList:BG13250" /db_xref="UniProtKB/Swiss-Prot:O34738" /translation="MKSWKVKEIVIMSVISIVFAVVYLLFTHFGNVLAGMFGPIAYEP IYGIWFIVSVIAAYMIRKPGAALVSEIIAALVECLLGNPSGPMVIVIGIVQGLGAEAV FLATRWKAYSLPVLMLAGMGSSVASFIYDLFVSGYAAYSPGYLLIMLVIRLISGALLA GLLGKAVSDSLAYTGVLNGMALGKELKKKRKRASEHASL*" /label="thiV CDS" gene complement(1271634..1272233) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /label="thiV gene" CDS complement(1272235..1272837) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15451668, 16291685, 16356850, 20471400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15451668, 16291685, 16356850, 20471400; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiamine-binding protein (oxidation stress protein)" /protein_id="NP_389207.1" /db_xref="EnsemblGenomes-Gn:BSU13240" /db_xref="EnsemblGenomes-Tr:CAB13181" /db_xref="GOA:O34911" /db_xref="InterPro:IPR011522" /db_xref="InterPro:IPR015835" /db_xref="InterPro:IPR029756" /db_xref="PDB:1S7H" /db_xref="PDB:1S99" /db_xref="PDB:1SBR" /db_xref="SubtiList:BG13251" /db_xref="UniProtKB/Swiss-Prot:O34911" /translation="MEHICGTSRIAGFRFSLYPMTDDFISVIKSALKKTDTSKVWTKT DHISTVLRGSIDHVFDAAKAIYLHAANSEQHIVMNGTFSIGCPGDTQGDTYLSKGDKR VNEDAVRGLKAEAPCQFALYPMNEPDYMGLIMEAVDIAKAQGTFVQGVHYASELDGDA HDVFSTLEAVFRMAEQQTNHITMTVNLSANSPSRKNRKQG*" /label="thiU CDS" gene complement(1272235..1272837) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /label="thiU gene" downshifts complement(1272915) /Source="Nicolas_upshifts" /id="D726" /incds=0 /nref=28 /ntot=88 /MaxReadThrough="7.47395" /MaxDrop="5.73297" /score="19.7469386" /energy="-10.9" /TU="U1069" /idTUdmin="U1069" /TUdmin="-3629" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1272934..1273046) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /product="thiamine pyrophosphate riboswitch" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswB RNA" gene complement(1272934..1273046) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /label="tswB gene" promotor_-35 1273047..1273050 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1273061..1273080) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1273066..1273085 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1273077 /Source="Nicolas_upshifts" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1273082) /Source="Nicolas_upshifts" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1273095..1273102) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1273148..1273834 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YkoH]" /protein_id="NP_389208.1" /db_xref="EnsemblGenomes-Gn:BSU13250" /db_xref="EnsemblGenomes-Tr:CAB13182" /db_xref="GOA:O34903" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13252" /db_xref="UniProtKB/Swiss-Prot:O34903" /translation="MEKGHILIVEDEEKIARVLQLELEYEGYSVTIKHNGTEGLDAAA EGGYSLVLLDVMLPGLSGLEVLRRLRKTDSQTPVILLTARDSIPDKVTGLDIGANDYV TKPFEIEELLARIRAALRQNGTKTEDIGTFLTYDDLRVNEKTREVRRGDKEVELTPRE FDLLVYMLKHPQQVLTREQILSSVWGFDYIGDTNVVDVYIRYIRKKLDYPYEKQLIHT IRGVGYAIKG*" /label="ykoG CDS" gene 1273148..1273834 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /label="ykoG gene" CDS 1273838..1275202 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YkoG]" /protein_id="NP_389209.1" /db_xref="EnsemblGenomes-Gn:BSU13260" /db_xref="EnsemblGenomes-Tr:CAB13183" /db_xref="GOA:O34638" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13253" /db_xref="UniProtKB/Swiss-Prot:O34638" /translation="MKLKTKIHLYTSISLLILLILVHTAVYLIFSSALTSKDAARLAD ETDNIAEALRAAETEGVALQDMLQAYLPANGMVRVVNGDQKAVMTITKEKAYKDFPLS FHSGETADVRKPDGKLFAEAAVPVIWTDGQVVSLQLVERLENTEESLFLLKIILIAAS AAVCIASFFAGSLLARRIINPIRRLMITMKDIQRDKEFKTISLEGQSNDELYQMGLTF NEMAMMLKEHYDKQQQFVQDASHELKTPLTIIESYSSLMKRWGAKKPEVLEESIEAIH SEAVHMKKLTNQLLALAKSHQGLEVDLKTIDLIKAARAVMQTLQSVYQRDILLETDKE SLLVKADEERIKQLLTILLDNAIKYSEKPIEMSAGTRNGRPFLSVRDEGIGIPEEHIP HLFERFYRADEARNRKTGGTGLGLSIAKQIADEHGIELSVKSKPGQGTAVTMQFSEQN GGGR*" /label="ykoH CDS" gene 1273838..1275202 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /label="ykoH gene" CDS 1275199..1275879 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295; Product type m : membranecomponent" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389210.1" /db_xref="EnsemblGenomes-Gn:BSU13270" /db_xref="EnsemblGenomes-Tr:CAB13184" /db_xref="GOA:O34551" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13254" /db_xref="UniProtKB/Swiss-Prot:O34551" /translation="MTKTIKTVSFAAAAILVVIICTFLIIRQTHENVLSKETVVKKVE ASYEGKVTKATQSKDKKTYDITLENPKGTYFVKADAISADILSMNRVKAVNPSAMTEK EAEHLALERVPGTVKKQTRQSQVATYTIQKEDGKTYEVKVDMQAKTVLSADQISSKDQ QKTPITKKEAKTIAERKTGGTADDADLEESEGTLIFEVDVDLPDNKEATVKINAYTGK VANIVYED*" /label="ykoI CDS" gene 1275199..1275879 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /label="ykoI gene" promotor_-35 1275908..1275913 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1275929..1275947 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1275932 /Source="Nicolas_upshifts" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1275971..1276483 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17209068; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389211.1" /db_xref="EnsemblGenomes-Gn:BSU13280" /db_xref="EnsemblGenomes-Tr:CAB13185" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13255" /db_xref="UniProtKB/Swiss-Prot:O35012" /translation="MLKKKWMVGLLAGCLAAGGFSYNAFATENNENRQASSKTDALTE QEAEAIAKTVVDGTVEDIDRDLYNGKEVYEVEIEKEGEDYDVYVDIHTKQALNDPLKE KAEQVAITKEEAEEIALKQTGGTVTESKLDEDDGAYIYEMEIQTKQGTETEFEISAKD GRIIKQEIDD*" /label="ykoJ CDS" gene 1275971..1276483 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /label="ykoJ gene" downshifts 1276469 /Source="Nicolas_upshifts" /id="D727" /incds=0 /nref=52 /ntot=228 /MaxReadThrough="3.74302" /MaxDrop="6.03059" /score="28.1760649" /energy="-13.7" /TU="U1070" /idTUdmin="U1070" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-35 1276514..1276520 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1276534..1276545 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1276535 /Source="Nicolas_upshifts" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1276566..1276703 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389212.1" /db_xref="EnsemblGenomes-Gn:BSU13290" /db_xref="EnsemblGenomes-Tr:CAB13186" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG13332" /db_xref="UniProtKB/Swiss-Prot:O34405" /translation="MEKKEEQYINQAEYVPHPTKEGEYALFLHETYHLLSEDDETQTT E*" /label="ykzD CDS" gene 1276566..1276703 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /label="ykzD gene" downshifts 1276676 /Source="Nicolas_upshifts" /id="D728" /incds=0 /nref=7 /ntot=31 /MaxReadThrough="1.81189" /MaxDrop="3.56977" /score="-4.52149284" /energy="-5.9" /TU="NA" /idTUdmin="U1070" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 1276762..1276769 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1276783..1276802 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1276785..1277104 /Source="Nicolas_S_feature" /locus_tag="new_1395590_1395909" /HighExp="LBGstat, LBGtran, M40t45, MG 25, Mt0, Salt, MG 45, LPhT, BMM, MG t5" /AntisenseName="ykzO" /AntisenseCor="-0.16301119751811899" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S473" upshifts 1276785 /Source="Nicolas_upshifts" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1276817..1276970 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /product="magnesium riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 17803910, 21315082, 28455443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 17803910, 21315082, 28455443; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" /label="swmG RNA" gene 1276817..1276970 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /label="swmG gene" promotor_-35 1277082..1277091 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1277104..1277123 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1277106..1277207 /Source="Nicolas_S_feature" /locus_tag="new_1395911_1396012" /HighExp="LBGstat, LBGtran, M40t45, Mt0, LPhT, Paraq, MG t5, MG 25, MG 60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99773400000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.876, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S474" upshifts 1277106 /Source="Nicolas_upshifts" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="upshifts" CDS 1277208..1278563 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 22970223, 24415722, 24968120, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 22970223, 24415722, 24968120, 25182490; Product type t : transporter" /codon_start=1 /transl_table=11 /product="magnesium transporter" /protein_id="NP_389213.1" /db_xref="EnsemblGenomes-Gn:BSU13300" /db_xref="EnsemblGenomes-Tr:CAB13187" /db_xref="GOA:O34442" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006667" /db_xref="InterPro:IPR006668" /db_xref="InterPro:IPR006669" /db_xref="InterPro:IPR036739" /db_xref="SubtiList:BG13256" /db_xref="UniProtKB/Swiss-Prot:O34442" /translation="MVQNMTYDELILRIIILLRDGKIRDFRSVIDELQPYDMAFIFKE MPEKHRARYLSYLTVDDITDMIGELEREFQLVVLNKVGKTKATLAMNKMDNDDLAQLL EEMDEELKEQLLSSMEASESKAVQLLMNYPADSAGRMMTNRYVWIPQHYTVKDAVVKL KSFAEIAESINYLYVINESKQLVGVLSYRDLILGEPEEKVQDLMFTRVISADALQDQE EVARLIERYDFLAIPVVEENNVLVGIVTVDDIIDVVIREADEDYEKFAASGKDITFDT KAYVAAYRRLPWLILLLFIGLISGSIISYFEDALKQVVALAFFMPMVSGMTGNTGTQS LAVVIRGLSKEEMNKKTIVRLIFREFRTSIFIGAVCSVLIAIVSIIWQGNALLGFVVA SSLFLTLIIGTMSGTIIPIILHKLKVDPAIASGPLITTLNDILSLLIYFGIATAFIHS L*" /label="mgtE CDS" gene 1277208..1278563 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /label="mgtE gene" downshifts 1278554 /Source="Nicolas_upshifts" /id="D729" /incds=0 /nref=160 /ntot=239 /MaxReadThrough="1.02063" /MaxDrop="7.38933" /score="-4.14569718" /energy="-8.9" /TU="NA" /idTUdmin="U1072" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1278606..1278938) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen sensing transcriptional regulator" /protein_id="NP_389214.1" /db_xref="EnsemblGenomes-Gn:BSU13310" /db_xref="EnsemblGenomes-Tr:CAB13188" /db_xref="GOA:Q45666" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG11805" /db_xref="UniProtKB/Swiss-Prot:Q45666" /translation="MTTEDHSYKDKKVISIGIVSELTGLSVRQIRYYEERKLIYPQRS SRGTRKYSFADVERLMDIANKREDGVQTAEILKDMRKKEQMLKNDPQVRKKMLEGQLN AHFRYKNR*" /label="tnrA CDS" gene complement(1278606..1278938) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /label="tnrA gene" promotor_-10 complement(1278954..1278973) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1278964) /Source="Nicolas_upshifts" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1278966..1279354) /Source="Nicolas_S_feature" /locus_tag="new_1397771_1398159_c" /HighExp="M9-stat, BC, LoTm, T1.30H, T0.30H, T2.0H, S8, C30, T4.0H, T2.30H" /AntisenseName="ykzB" /AntisenseCor="-3.3870578787867499E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.92" /TUlongSig="NA" /TUlongPSig="NA" /label="S475" promotor_-35 complement(1278989..1278994) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1279026..1279126 /Source="Nicolas_upshift_promotors" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1279086 /Source="Nicolas_upshifts" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="upshifts" CDS 1279133..1279288 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389215.1" /db_xref="EnsemblGenomes-Gn:BSU13320" /db_xref="EnsemblGenomes-Tr:CAB13189" /db_xref="SubtiList:BG13330" /db_xref="UniProtKB/Swiss-Prot:O34923" /translation="MEEEKAVSLAKEIIELDIKRDEMLETFMQLAGEQAFQLLRSVQN GQYRKSS*" /label="ykzB CDS" gene 1279133..1279288 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /label="ykzB gene" promotor_-35 1279297..1279304 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1279311..1279328 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1279328 /Source="Nicolas_upshifts" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1279339..1279358) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1279354) /Source="Nicolas_upshifts" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1279372..1279378) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1279376..1279558 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389216.1" /db_xref="EnsemblGenomes-Gn:BSU13330" /db_xref="EnsemblGenomes-Tr:CAB13190" /db_xref="SubtiList:BG13257" /db_xref="UniProtKB/Swiss-Prot:O34763" /translation="MSNLLKSALEKERRHYSEKLYQIGVYNKEVMNKMTISELRKEYA YFFRSITNHKNYPYTR*" /label="ykoL CDS" gene 1279376..1279558 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /label="ykoL gene" downshifts 1279526 /Source="Nicolas_upshifts" /id="D730" /incds=0 /nref=2 /ntot=8 /MaxReadThrough="3.83398" /MaxDrop="4.6651" /score="19.6832496" /energy="-11.2" /TU="U1076" /idTUdmin="U1075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1279583..1279591 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1279602..1279620 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1279608..1279690 /Source="Nicolas_S_feature" /locus_tag="new_1398413_1398495" /HighExp="T3.0H, M9-stat, T1.30H, T2.30H, Lbstat, T3.30H, Lbtran, S2, T4.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, Sig-" /TUshortPSig="0.996, 0.00699" /TUlongSig="NA" /TUlongPSig="NA" /label="S476" upshifts 1279608 /Source="Nicolas_upshifts" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="upshifts" CDS 1279691..1280155 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_389217.1" /db_xref="EnsemblGenomes-Gn:BSU13340" /db_xref="EnsemblGenomes-Tr:CAB13191" /db_xref="GOA:O34949" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13258" /db_xref="UniProtKB/Swiss-Prot:O34949" /translation="MMRLSFNEEEVERAMNLYRVFARAFKSVSEHSIRDSKEHGFNPT EFAVLELLYTRGPQKLQQIGSRLLLVSGNVTYVIDKLERNGFLVREQDPKDKRSVYAH LTDKGNEYLDKIYPIHALRIARAFSGLSPDEQDQLIVLLKKAGIHSQHLLFR*" /label="ykoM CDS" gene 1279691..1280155 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /label="ykoM gene" downshifts 1280140 /Source="Nicolas_upshifts" /id="D731" /incds=0 /nref=70 /ntot=210 /MaxReadThrough="2.86787" /MaxDrop="5.38705" /score="24.8730632" /energy="-9.8" /TU="U1078" /idTUdmin="U1078" /TUdmin="-112" /isTUend="FALSE" /label="downshifts" CDS complement(1280170..1281291) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389218.2" /db_xref="EnsemblGenomes-Gn:BSU13350" /db_xref="EnsemblGenomes-Tr:CAB13192" /db_xref="GOA:C0SPB9" /db_xref="InterPro:IPR009695" /db_xref="SubtiList:BG13259" /db_xref="UniProtKB/Swiss-Prot:C0SPB9" /translation="MKNILIFPFLSISTGHHHVADALQAELESQGLAAEKIDIFSHSY RRLEKLSSVAYLKWIQYFPKTYSGIYRLLACGEFQHDKRYFMYEWLFTQQMRHILQEK QPDIAFCTHALPSYLLNRLKPEYPNLTVVNVYTDFFVNQLWGRKNIDYHFVPSTEVKK QLISEGIDQNNIYLTGIPVHQNFEMESADTLQHHPPYTIIITGGSMGVGGILKWVQEL SPGGKILYKILCGRNEKLYSYVKSLHHPLIEAIPYLHSKAEMNRLYEQATGIMTKPGG VTISECLQKRLPVFIYHALPGQEEMNLNLLHERKLVTDMRNWDMQKAEEYIAAFFQSN EQMKEYKKHVNGYLGEMSDRKIKDVLKRIIWKQKNTLLK*" /label="ykoN CDS" gene complement(1280170..1281291) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /label="ykoN gene" promotor_-35 1280579..1280587 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1280601..1280620 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1280604..1281382 /Source="Nicolas_S_feature" /locus_tag="new_1399409_1400187" /HighExp="S6, S8, S7, S5, BT, B36, S4, S3, Pyr, G/S" /AntisenseName="ykoN" /AntisenseCor="0.84084970563549499" /AntisenseRegPval="-72.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S477" upshifts 1280604 /Source="Nicolas_upshifts" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1281320..1281331) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1281340) /Source="Nicolas_upshifts" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1281346..1281352) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1281383..1281934 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389219.2" /db_xref="EnsemblGenomes-Gn:BSU13360" /db_xref="EnsemblGenomes-Tr:CAB13193" /db_xref="SubtiList:BG13260" /db_xref="UniProtKB/Swiss-Prot:O34495" /translation="MKTCFLSIWRVVDPIYFFFSRLSLIDNDQKSVFRVRLTKYKGHH VVLSDGTHIRKNDVLVKIHLHNIKLIRELQSIESAVRKGIIIYQKVYQSMPLLLDYIN NHKKSEKIKGIIGITMLDKGVERLGFDVITPVNPFYRCFKKVSHVPILYLTSKPVSLR HLPNSSYLFISKEKLQKTYQKKD*" /label="ykoP CDS" gene 1281383..1281934 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /label="ykoP gene" downshifts 1281902 /Source="Nicolas_upshifts" /id="D732" /incds=0 /nref=4 /ntot=25 /MaxReadThrough="3.31887" /MaxDrop="3.7149" /score="-2.92393792" /energy="-7" /TU="U1079" /idTUdmin="U1079" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" CDS complement(1281962..1282774) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metallophosphoesterase" /protein_id="NP_389220.1" /db_xref="EnsemblGenomes-Gn:BSU13370" /db_xref="EnsemblGenomes-Tr:CAB13194" /db_xref="GOA:O35040" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13261" /db_xref="UniProtKB/Swiss-Prot:O35040" /translation="MFTILLSLAILVFVPFLYKANRNTKDVKVNTISIDQKDGLPARK KLNILHLSDLHLENISVSPEELYHLTKDQPVDIIALTGDFLDRKRNIPKLAGYLNALQ KLKPAYGMYAVFGNHDYVLKEEDFQRLKRVLEENGCITLQNEHVRIETAAGPVNIIGI DDYSTNRSNITGSYQSLENGYHLVLTHDPNIILDMKDVHYDYLLSGHFHGGQIHWPKP YHLVKMGKLVRMNMIKGLHYHHDKPFYISEGLGQTGVNIRVGSRPEVTFHQI*" /label="ykoQ CDS" gene complement(1281962..1282774) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /label="ykoQ gene" promotor_-10 complement(1282734..1282753) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1282748) /Source="Nicolas_upshifts" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1282767..1282772) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1282875..1282881 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1282892..1282966 /Source="Nicolas_S_feature" /locus_tag="new_1401697_1401771" /HighExp="S5, S6, S7, S4, S8, T5.0H, ferm, nit, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S478" upshifts 1282892 /Source="Nicolas_upshifts" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1282895..1282906 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1282967..1284661 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389221.1" /db_xref="EnsemblGenomes-Gn:BSU13380" /db_xref="EnsemblGenomes-Tr:CAB13195" /db_xref="GOA:O34830" /db_xref="SubtiList:BG13262" /db_xref="UniProtKB/Swiss-Prot:O34830" /translation="MLRLMRQQKKETYYLWIALFLLLLYVSPLFILKEDAHIRVHDNL DSNIAWYKVLADSGEIVGKVDAAIPQIINGLPRDAFGTEWSGIVWLHAFFSSMTAYAI SQTVTRVVAFFGMYVLLKKHIIPEPKAAFIRIGVSLAFALTPFWPSGMLSTLGYPLAL WAFLNIRKGDISWREWLTLGLLPLYSSFVLGFFFFLAGMACFWLYDAITKRRWNLMFL GSIAFMTSIYLFVEYRLVYSMLFEHAPMHRIEFISSRHDVWHSLRLSIKNFVYGHNHV MTVHTVVILPILMVVFAALLFKRNRTKPENVYLFLCVLNYGLSLWYAFWFNKIWAVPK QKFAFLAEFNFARFHFLRPLVIYVSFALALYLIWRMGKGWKWLVYAAVAAQLMVLAPF NEEYTYGVHYNAPTFREFYASEQFKEIKEYIGRPQDSYRVASIGLHPSIAQYNGFYTL DTYNNLYPLSYKYEFRKIIEKELEKNSRLKQYFDEWGSRCYLFVDELGKRYDFKKNSK KTINNLQLNTDVFKKMGGRYIFSSVPIMNAEQNHLALVKTFDHKDSAWRIYLYETR*" /label="ykoS CDS" gene 1282967..1284661 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /label="ykoS gene" CDS 1284674..1285687 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /EC_number="2.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389222.1" /db_xref="EnsemblGenomes-Gn:BSU13390" /db_xref="EnsemblGenomes-Tr:CAB13196" /db_xref="GOA:O34755" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13263" /db_xref="UniProtKB/Swiss-Prot:O34755" /translation="MKQSQPVLTIVVPCFNEEEVFQETSHQLTEVVDDLIEEKLIAED SKILFVDDGSKDRTWALIAMESIRNKKVTGLKLACNVGHQKALLAGLHKAKNRSDCVI SIDADLQDDISVIRDFMLKYHEGCEIVYGVRRSRKTDTFFKRTTALGFYRLMNKLGIK LIYNHADFRLMNKRSLEELERYPEANLFLRGIVPMIGFKSAEVLYDRKERFAGKTKYP LKKMLSFAFNGITSFSVAPIRFFTLLGFVLFFLSAVAGIGAFIQKLLGHTNAGWASLI ISIWFLGGLQLMGIGIIGEYIGTIFSEVKRRPKYAIDIDLYNEQLSPLQRQEKERLEK KYS*" /label="ykoT CDS" gene 1284674..1285687 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /label="ykoT gene" downshifts 1285672 /Source="Nicolas_upshifts" /id="D733" /incds=0 /nref=13 /ntot=35 /MaxReadThrough="0.53349" /MaxDrop="4.80671" /score="19.4012674" /energy="-13.7" /TU="NA" /idTUdmin="U1082" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(1285713..1287548) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /EC_number="6.5.1.1" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12215643, 16497325, 17293412, 23691176, 25355514, 26826709" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12215643, 16497325, 17293412, 23691176, 25355514, 26826709; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit; 5'-2-deoxyribose-5-phosphate (dRP) lyase" /protein_id="NP_389223.1" /db_xref="EnsemblGenomes-Gn:BSU13400" /db_xref="EnsemblGenomes-Tr:CAB13197" /db_xref="GOA:O34398" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR014143" /db_xref="InterPro:IPR014145" /db_xref="InterPro:IPR014146" /db_xref="InterPro:IPR033652" /db_xref="SubtiList:BG13264" /db_xref="UniProtKB/Swiss-Prot:O34398" /translation="MAFTMQPVLTSSPPIGAEWRYEVKYDGYRCILRIHSSGVTLTSR NGVELSSTFPEITQFAKTAFQHLEKELPLTLDGEIVCLVNPCRADFEHLQVRGRLKRP DKIQESANARPCCFLAFDLLERSGEDVTLLSYLDRKKSLRELISAAKLPASPDPYAKE TIQSIPCYDHFDQLWEMVIKYDGEGIVAKKTNSKWLEKKRSSDWLKYKNFKQAYVCIT GFNPNNGFLTVSVLKNGIMTPIASVSHGMRDEEKSAIREIMEQHGHQTPSGEFTLEPS ICAAVQYLTILQGTLREVSFIGFEFQMDWTECTYAQVIRHSKPVHPKLQFTSLDKIIF EKNKKTKEDFIQYMIEVSDYLLPFLKNRAVTVIRYPHGSRSESFFQKNKPDYAPDFVQ SFYDGSHEHIVCEDMSTLLWLCNQLALEFHVPFQTIKSRRPAEIVIDLDPPSRDDFLM AVQAANELKRLLDSFGITSYPKLSGNKGIQLYIPLSPEAFTYEETRQFTQLIAEYCTN AFPELFTTERLIKNRHCKLYLDYLQHAEGKTIICPYSTRGNELGTVAAPLYWHEVQSS LTPALFTIDTVIDRIKKQGCPFFDFYRNPQDEPLSAILHQLKKKS*" /label="ligD CDS" gene complement(1285713..1287548) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /label="ligD gene" downshifts complement(1285762) /Source="Nicolas_upshifts" /id="D734" /incds=0 /nref=10 /ntot=54 /MaxReadThrough="0.67916" /MaxDrop="5.08051" /score="-8.48510187" /energy="-13.7" /TU="NA" /idTUdmin="U1083" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1287552..1288487) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11095673, 12215643, 16497325, 16780573, 23691176, 25355514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11095673, 12215643, 16497325, 16780573, 23691176, 25355514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit Ku; AP/deoxyribose 5'-phosphate (5'-dRP)-lyase" /protein_id="NP_389224.1" /db_xref="EnsemblGenomes-Gn:BSU13410" /db_xref="EnsemblGenomes-Tr:CAB13198" /db_xref="GOA:O34859" /db_xref="InterPro:IPR006164" /db_xref="InterPro:IPR009187" /db_xref="InterPro:IPR016194" /db_xref="SubtiList:BG13265" /db_xref="UniProtKB/Swiss-Prot:O34859" /translation="MNRTPSLHTKEKKGFIDMHTMWKGSISFGLVNIPIKLYAATEDK DIKLRSLHKEDHAPIKYEKVCTNCEKTLSPDEIVKGYEYVKGKYVVLTDEDLKSLKQE HEEKAVEIVDFVQLQEIDPIYFNRSYFVGPGDNGTKAYTLLREALRSTGKIGIANMTI RSKQQLAILRVYENCIVMESIHYPDEVRSAAQVPGVPDQSNVNDKELQTAITLIDELT AKFEPEKYEDTYRQALLQRVNDKLENKETAVTPDKAPPREDVIDLVSALQASIDRTRR PNRETPAAAPAQAAEPKGAGDKKQKTTRKKASGTS*" /label="ligV CDS" gene complement(1287552..1288487) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /label="ligV gene" promotor_-10 complement(1288458..1288469) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1288468) /Source="Nicolas_upshifts" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1288484..1288490) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1288524..1290926) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11728710, 17010156, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11728710, 17010156, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="YP_054577.2" /db_xref="EnsemblGenomes-Gn:BSU13420" /db_xref="EnsemblGenomes-Tr:CAB13199" /db_xref="GOA:O34311" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR005330" /db_xref="InterPro:IPR029787" /db_xref="InterPro:IPR035919" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG13266" /db_xref="UniProtKB/Swiss-Prot:O34311" /translation="MEIHVTYNTTLICLSILIACTASYISLELSRKVTINTGLKSKIW LIGGSLIMGFGIWSMHFVGMMAVHMEMPMEYEFMPLMAAIGASVSGSFVSLYFVSRHI LTYYRLLTGSVVLGASIASMHYIGMSAISRVMIIYEPILFTVSIIIAIAASFVSLKIF FDLAVKKHSEHLIFYKGVSSIVMGIGISGMHYTGMLAATFHKDMAPPGSHMEVQTFHW SIFVTLIIFCIQTLLLFSSHADRKFIKQSERIKDNEQRFQSLIVHNIDAIFILSLEGD IISSNHAGEEMISKFGFSMHDWRNYTSLKVKRLFEQVKKDKQAMNSDSDLITEKGQFH LNITLIPVEVNQELDSIYVICKDMTKQYKAEKEIHRMAHYDSLTDLPNRRHAISHLTK VLNREHSLHYNTVVFFLDLNRFKVINDALGHNVGDQLLQFAAKRLSSVVPDNGFIARL GGDEFIIILTDANTGTGEADVLARKIIQKFKKPFKIQDHTLVTSVSIGIAISPKDGTD GLELMKKADMAMYAAKERNKSKYRYYSFSIGNKETVKLNQEMVLREAIENDRFVLHYQ PQFSVKKQKMTGAEALIRLVTPDGQLRPPGEFIGVAEETGLIIDIGKWIIDEACKQAR IWHDKGYDLSVAINISARQFQSKDLIPLIKDTLNKYQLPPQLLEVEVTESMTMDNLNH SKKVLSSLTELGIRISIDDFGTGHSSLSYLKDFPIHRLKIDKSFIDDIQTHPKSEQIT GAIIAMGHQLSLQVIAEGVENAAQKQLLFEKGCDHLQGFFFSRPIPPEQFEQFIIEQP SQ*" /label="dgcW CDS" gene complement(1288524..1290926) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /label="dgcW gene" downshifts complement(1288556) /Source="Nicolas_upshifts" /id="D735" /incds=0 /nref=13 /ntot=101 /MaxReadThrough="1.93589" /MaxDrop="3.26543" /score="6.55794882" /energy="-9" /TU="NA" /idTUdmin="U1084" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1290774..1290976) /Source="Nicolas_S_feature" /locus_tag="new_1409579_1409781_c" /HighExp="Cold, GM 25, GM 10, GM 45, GM 15, GM-0.2, GM-0.1, GM 5, GM 90, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S479" promotor_-10 complement(1290965..1290983) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1290976) /Source="Nicolas_upshifts" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1290997..1291004) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1291043..1291050 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1291064..1291083 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1291076 /Source="Nicolas_upshifts" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="upshifts" CDS 1291107..1291772 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23687963; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389226.1" /db_xref="EnsemblGenomes-Gn:BSU13430" /db_xref="EnsemblGenomes-Tr:CAB13200" /db_xref="GOA:O34908" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13267" /db_xref="UniProtKB/Swiss-Prot:O34908" /translation="MIHKHETRELVAIEELVMSWIEAFKSLSYFGIFLALSIEFIPAE VVLPLAGYWVSKGDMTLAGVVLAGSLGGVAGPLTLYWIGRYGGRPFLERFGKYLFIKP EALDKSDNFFKKHGGFVAFSGRFLPGIRTLISIPCGIAKMNVWVFSLYTFIAMLPITF VYVYLGVKLGENWKAVGSILDQYMLPIGIAILALFLLYLLMKKRKKRTHSEQLSVFLK NKR*" /label="ykoX CDS" gene 1291107..1291772 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /label="ykoX gene" promotor_-10 complement(1291641..1291660) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1291658) /Source="Nicolas_upshifts" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1291674..1291683) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1291767..1291774 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1291789..1291808 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1291802 /Source="Nicolas_upshifts" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1291828..1291961 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /product="manganese ion riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" /label="mnrW RNA" gene 1291828..1291961 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /label="mnrW gene" CDS 1291849..1292823 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 15849754, 16850406, 25794618, 25794619; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative manganese-related ion transporter" /protein_id="NP_389227.1" /db_xref="EnsemblGenomes-Gn:BSU13440" /db_xref="EnsemblGenomes-Tr:CAB13201" /db_xref="GOA:O34997" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13268" /db_xref="UniProtKB/Swiss-Prot:O34997" /translation="MYSGNKVVISWIVSIGFVGMPEFMSSKTFALCRQRSFLHGPAGI RSDEEKENNFFGRVSFMDAALLLEYGWVLLVLIGLEGILAADNALVMAVMVKHLPEEK RKKALFYGLAGAFVLRFGSLFAISFLVNVWQVQAIGAIYLLYISASHLLKRYVFKKED THKETKQSGFWPTVLKVELADIAFAVDSILAAVALAVTLPGTSLPKIGGLDGGQFLVI LAGGIIGLVIMRFAASMFVKLLKERPSLETAAFVIVGWVGVKLALYTLAHRDIAVVSE HFIHSGTWKLIFWGVLAAIAVCGWFMSGGKKQPEGAQNEQKNSTRERA*" /label="ykoY CDS" gene 1291849..1292823 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /label="ykoY gene" downshifts 1291912 /Source="Nicolas_upshifts" /id="D736" /incds=1 /nref=38 /ntot=211 /MaxReadThrough="5.00041" /MaxDrop="4.46498" /score="15.8563987" /energy="-15" /TU="U1085,U1087" /idTUdmin="U1085" /TUdmin="-902" /isTUend="FALSE" /label="downshifts" downshifts 1292811 /Source="Nicolas_upshifts" /id="D737" /incds=0 /nref=16 /ntot=175 /MaxReadThrough="2.59801" /MaxDrop="4.20782" /score="24.4740487" /energy="-13.7" /TU="NA" /idTUdmin="U1085" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 1292933..1292941 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1292955..1292963 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1292965 /Source="Nicolas_upshifts" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="upshifts" S_feature 1292968..1293054 /Source="Nicolas_S_feature" /locus_tag="new_1411773_1411859" /HighExp="M9-stat, T1.30H, T1.0H, T0.30H, T2.0H, T2.30H, HiTm, M0t90, T3.0H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29969800000000002" /TUshortSig="SigI" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S480" promotor_-35 1293027..1293034 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1293048..1293067 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1293056 /Source="Nicolas_upshifts" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="upshifts" CDS 1293087..1293842 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma factor (heat stress responsive)" /protein_id="NP_389228.1" /db_xref="EnsemblGenomes-Gn:BSU13450" /db_xref="EnsemblGenomes-Tr:CAB13218" /db_xref="GOA:O31654" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014244" /db_xref="InterPro:IPR014284" /db_xref="SubtiList:BG13269" /db_xref="UniProtKB/Swiss-Prot:O31654" /translation="MKPVLSLLFKLGKKKQTLEKAVESIQKGNKDLQNELIQQYKPFI AKTVSSVCKRYIDEKDDEFSIGLIAFNEAIEKYSPEKGNSLLAFAELIIKRKVIDYIR KEARSAQNINIDLQEGDDQESSQSLIEAELSIDEYRRQIEQEQRREEILYFQKQLKDY GLSFKELLENSPKHTDARQNAIKVAMTLVEHEELAAILYTKKQLPVKQLEQLVSVSRK TIERNRKYIIAMCIIITGDYIYLKDYLKGVLHS*" /label="sigI CDS" gene 1293087..1293842 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /label="sigI gene" CDS 1293839..1294984 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17185538, 23199363, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17185538, 23199363, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="sigmaI modulating factor" /protein_id="NP_389229.1" /db_xref="EnsemblGenomes-Gn:BSU13460" /db_xref="EnsemblGenomes-Tr:CAB13219" /db_xref="GOA:O31655" /db_xref="InterPro:IPR024449" /db_xref="SubtiList:BG13272" /db_xref="UniProtKB/Swiss-Prot:O31655" /translation="MRRGIIVEKNKKFVTLLTPDGQFLKAKNDRHSYEIGEEIMLPSE TRMGRRASFFDFFKLRPFKMGIFTMTAIMLFIFIVLPVFSNNKAYAYMTIDINPSVEM ALNSDYEVIELTPLNDEGQKVVNDIDDWEKTDFKKVIDDIITDCSEHGYVKKSKEILI STVYENTEDNTYKKAVKKQLNDVTEKYKTTYRMESLESDMQTREKAKKEGVSTGSYIK SNEKNDNKDIKDDSSKPSGEEDQKSDENEDENTDQTDTQDSKQGDNEQLNDADSGDQK EEKADDQIDDSDKDKKIKESDENTNTEKDGDHEQTPIQDPQDKGNENNGADKGQSQYH RDWNNGEQGKNRSSSRRDNASDRRNPNGYSSDNHSAKNEDSPSAPGE*" /label="rsgI CDS" gene 1293839..1294984 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /label="rsgI gene" S_feature 1294985..1296144 /Source="Nicolas_S_feature" /locus_tag="new_1413790_1414949" /HighExp="HiTm, G135, G180, C30, G150, Cold, S8, MG 25, H2O2, Lbstat" /AntisenseName="ykrK" /AntisenseCor="0.122248209149143" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigI" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S481" CDS complement(1294995..1295189) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:3009397, 3112127, 3121585, 9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009397, 3112127, 3121585, 9852018; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_389230.1" /db_xref="EnsemblGenomes-Gn:BSU13470" /db_xref="EnsemblGenomes-Tr:CAB13220" /db_xref="GOA:P04833" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10788" /db_xref="UniProtKB/Swiss-Prot:P04833" /translation="MASRNKLVVPGVEQALDQFKLEVAQEFGVNLGSDTVARANGSVG GEMTKRLVQQAQSQLNGTTK*" /label="sspD CDS" gene complement(1294995..1295189) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /label="sspD gene" downshifts complement(1295002) /Source="Nicolas_upshifts" /id="D738" /incds=0 /nref=24 /ntot=36 /MaxReadThrough="1.67859" /MaxDrop="4.68215" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1090" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1295232..1295243) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1295242) /Source="Nicolas_upshifts" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1295258..1295264) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1295320..1296021) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22447908, 23042994" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22447908, 23042994; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of quality control" /protein_id="NP_389231.1" /db_xref="EnsemblGenomes-Gn:BSU13480" /db_xref="EnsemblGenomes-Tr:CAB13221" /db_xref="InterPro:IPR014975" /db_xref="SubtiList:BG13273" /db_xref="UniProtKB/Swiss-Prot:O31656" /translation="MNIFKLSRTDMVRLLYSLKGQGEHSPLDILVQSANMSAEKAANH LEIPEFLTRYERKKQKKEYGLSTNEIVELGNLCELTSLKSTAIQNWVKRDIKDLIGHP ELGKKYSIEQAVILLIVRDLKSIYDFEHIRAILKVAFNTISDRSDDVISPIAYYESCA YVLDAIHHQDTPSMKESNLQEIAEQETERLRHRFEELNDSQWLKIRQIIAITVLSILT FHIQATAHKMTADIL*" /label="htpK CDS" gene complement(1295320..1296021) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /label="htpK gene" downshifts complement(1295354) /Source="Nicolas_upshifts" /id="D739" /incds=0 /nref=174 /ntot=231 /MaxReadThrough="2.96889" /MaxDrop="5.30355" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1091" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1296022..1296102) /Source="Nicolas_S_feature" /locus_tag="new_1414827_1414907_c" /HighExp="LBGtran, dia0, LBGexp, Lbexp, Oxctl, G180, M0t45, C90, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S482" promotor_-10 complement(1296094..1296113) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1296102) /Source="Nicolas_upshifts" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1296118..1296125 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1296127..1296134) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1296139..1296158 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1296146 /Source="Nicolas_upshifts" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="upshifts" CDS 1296192..1297088 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11860552, 12081643, 16076848, 16573693, 22447908, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane protease" /protein_id="NP_389232.1" /db_xref="EnsemblGenomes-Gn:BSU13490" /db_xref="EnsemblGenomes-Tr:CAB13222" /db_xref="GOA:O31657" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR022919" /db_xref="SubtiList:BG13274" /db_xref="UniProtKB/Swiss-Prot:O31657" /translation="MAKRIFLFILTNILVLTTIGIVLSVLSSVTGVGTYFTADGGIDP MALLVFSLVVGFVGSFTSLAISRWMAKTMMGVRVLNPKKHSLSYEEQQLVDRVHRLSR SAGLTKMPEVGIYRSPEVNAFATGPSKRRSLVAVSSGLLEQMDDAAVEGVLAHEVAHI TNGDMVTMTLLQGIVNTFVVFLSRIAAWIASRFVKEDLAPIVHFIAMIIFQIVFSILG SLVVFAYSRHREFHADRGGADLAGKDKMIHALRTLKSYSSRILEDDQTAVQTLKINGK KRSSLFSTHPDLDERIRRLEAK*" /label="htpX CDS" gene 1296192..1297088 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /label="htpX gene" downshifts 1297082 /Source="Nicolas_upshifts" /id="D740" /incds=0 /nref=203 /ntot=268 /MaxReadThrough="3.02778" /MaxDrop="6.27746" /score="38.5173589" /energy="-13.4" /TU="NA" /idTUdmin="U1092" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1297193..1297197 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1297213..1297232 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1297217 /Source="Nicolas_upshifts" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="upshifts" CDS 1297262..1298611 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /EC_number="3.6.3.12" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 23963175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 23963175; Product type t : transporter" /codon_start=1 /transl_table=11 /product="K+-transporting ATPase" /protein_id="NP_389233.1" /db_xref="EnsemblGenomes-Gn:BSU13500" /db_xref="EnsemblGenomes-Tr:CAB13223" /db_xref="GOA:O31658" /db_xref="InterPro:IPR003445" /db_xref="SubtiList:BG13275" /db_xref="UniProtKB/Swiss-Prot:O31658" /translation="MRLKFGKLIQALSPAQLIALYYFLAVTVAVILLSLPAAHKPGAD WTFIDALFTAVSSVSVTGLTVVDTADTFSTIGIFILAFVLQFGGIGIMTLGTFIWLIM GKRIGLKERKLIMVDQNQSQFSGIVNLMKQVLFLILWIEFFGGLILGTYFLTYYDSYQ EAYLHGFFASISATTNGGFDITGNSMIPFRHDYFVQFITMLLIIFGAIGFPVLVEVKD FLFSKHRRYPFTLFTKITTITFGSLVLFGAIGIFALEANHAFAGKSWHDILFLSLFQS TATRSGGLATIDISQLSDSTLFFICALMFIGASPSSVGGGIRTTTFALNLLALFHFAR GNKAVKVFKRELHPADLMKSLVVTMMAILLVFGATLILTITEKHSLLELLFEVCSAFG TTGLSLGITADLSSVGKCVIMIVMFIGRIGILTFLYLIGRKEIEANYHYPKERVIIG* " /label="ktrD CDS" gene 1297262..1298611 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /label="ktrD gene" downshifts 1298599 /Source="Nicolas_upshifts" /id="D741" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="0.838800000000001" /MaxDrop="4.37717" /score="20.0478288" /energy="-10.7" /TU="NA" /idTUdmin="U1093" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1298660..1298666 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1298680..1298691 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1298688..1298755 /Source="Nicolas_S_feature" /locus_tag="new_1417493_1417560" /HighExp="S8, S6, S7, S5, ferm, nit, BT, B36, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S483" upshifts 1298688 /Source="Nicolas_upshifts" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="upshifts" CDS 1298756..1298911 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097718.1" /db_xref="EnsemblGenomes-Gn:BSU13509" /db_xref="EnsemblGenomes-Tr:CAX52609" /db_xref="UniProtKB/Swiss-Prot:C0H402" /translation="MKRKAEVNEAIKNNNTPTESMDPNSYKTQYHDDPNFRGANRNSK QGQQGGM*" /label="ykzP CDS" gene 1298756..1298911 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /label="ykzP gene" CDS 1298914..1299090 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389234.1" /db_xref="EnsemblGenomes-Gn:BSU13510" /db_xref="EnsemblGenomes-Tr:CAB13224" /db_xref="SubtiList:BG13333" /db_xref="UniProtKB/Swiss-Prot:O31659" /translation="MKKNRHSRDMQNHKKPMNKKVLEEEFSSELGDYNAGKIIETLEV TKPEKKKEKNKKQQ*" /label="ykzE CDS" gene 1298914..1299090 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /label="ykzE gene" promotor_no_box 1298980..1299080 /Source="Nicolas_upshift_promotors" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1299040 /Source="Nicolas_upshifts" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1299086 /Source="Nicolas_upshifts" /id="D742" /incds=0 /nref=56 /ntot=112 /MaxReadThrough="2.40289" /MaxDrop="8.38761" /score="26.5107018" /energy="-19.7" /TU="NA" /idTUdmin="U1094" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(1299133..1300155) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /EC_number="2.3.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral membrane protein; putative acyltransferase" /protein_id="NP_389235.1" /db_xref="EnsemblGenomes-Gn:BSU13520" /db_xref="EnsemblGenomes-Tr:CAB13225" /db_xref="GOA:O31660" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG13276" /db_xref="UniProtKB/Swiss-Prot:O31660" /translation="MSKSRDSYFDNAKFLLIFLVVFGHILRSFINDNHFMLYLYKFIY TFHMPAFILVSGYFAKGFKRAGYVKKLAVKLIIPYLIFQIIYSVFYYIMQDESMANVN PIDPQWSLWFLVSLFFWNLLLYPFSKLSKQWALFVSCGIAVLIGYLDFVSSTLSLSRT FVFLPMFLVGFYLNKHHFDLLRSKRGKQIALGVLAAVFVICWGIDFDYSFLFGSKPYS SFGDVTLVSGLSRIGWYVLAFGATFSFLALVPQKRYFFTKWGTRTFYVYLLHGFIIKT LRQVGLEDWLTDYQSLVILLLLTAALTSVLSSNFVKTVAQPFIELRMTSLLQFVRGTG KNAYLK*" /label="ykrP CDS" gene complement(1299133..1300155) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /label="ykrP gene" downshifts complement(1299156) /Source="Nicolas_upshifts" /id="D743" /incds=0 /nref=11 /ntot=58 /MaxReadThrough="2.29259" /MaxDrop="3.64731" /score="30.4184602" /energy="-16.9" /TU="NA" /idTUdmin="U1096" /TUdmin=92 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1300200..1300219) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1300216) /Source="Nicolas_upshifts" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1300231..1300237) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1300344..1300352 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1300360 /Source="Nicolas_upshifts" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1300363..1300381 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1300408..1302624 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11069677, 12169614, 16166384, 25701730" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 12169614, 16166384, 25701730; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_389236.1" /db_xref="EnsemblGenomes-Gn:BSU13530" /db_xref="EnsemblGenomes-Tr:CAB13226" /db_xref="GOA:O31661" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13277" /db_xref="UniProtKB/Swiss-Prot:O31661" /translation="METLGVQTNSELREELNRLKEENARLKKELNQHQVIVNNTLDAI FICDNEMRIVQANEATERMLQVDSEDLKKRSVLDFLFSIPKDELNLSVKKFFKKGFLW KEVPIRLDCGATKYIEFLAKRGIGEDFFFVVMRDISSKKILEREFSMNEQLFKDLFDR AVDGIVLFDKDGGFIDANLSFCKSFEINHNELSHLSLYEFIDSGSRKDFDNIWKALNR KGKAKGELPVKLRSGVQKLFEFTITSNIISGFYMSIMRDITEKRSMELQLFKSEERFR EIFENAMDAIIIWSNDGRIVKANQSACKIFELPMNLLLKRKLCDFLVDSQQKYSITKR KYAKYGEIREELLFQMGNGQFKELEFTSKRTILENQHLTILRNVSDRKRMEKELRESE LKFRKVFNGSMDGNVLFDNQYRIIDANPLASHILGLSHEEIKQHSLLDIISAYEIENL ASPARQINFDEMDNEIPFLLSSGDNRKLEFSFKRNIIQNMNLAIFKDVTERKELEERL RKSDTLHVVGELAAGIAHEIRNPMTALKGFIQLLKGSVEGDYALYFNVITSELKRIES IITEFLILAKPQAIMYEEKHVTQIMRDTIDLLNAQANLSNVQMQLDLIDDIPPIYCEP NQLKQVFINILKNAIEVMPDGGNIFVTIKALDQDHVLISLKDEGIGMTEDKLKRLGEP FYTTKERGTGLGLMVSYKIIEEHQGEIMVESEEGKGTVFHITLPVRQNAEERRNDE*" /label="kinE CDS" gene 1300408..1302624 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /label="kinE gene" S_feature complement(1302399..1303339) /Source="Nicolas_S_feature" /locus_tag="new_1421204_1422144_c" /HighExp="Pyr, Glucon, C30, Glu, Mal, M/G, G/S, Heat, Fru, B36" /AntisenseName="ogt" /AntisenseCor="-0.33210294457391598" /AntisenseRegPval="-7.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S484" promotor_-35 1302477..1302484 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1302499..1302518 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1302501 /Source="Nicolas_upshifts" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="upshifts" CDS 1302621..1303118 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /EC_number="2.1.1.63" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2105461, 2308822, 2359121, 2506524, 7565865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105461, 2308822, 2359121, 2506524, 7565865; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O6-alkylguanine DNA alkyltransferase" /protein_id="NP_389237.1" /db_xref="EnsemblGenomes-Gn:BSU13540" /db_xref="EnsemblGenomes-Tr:CAB13227" /db_xref="GOA:P11742" /db_xref="InterPro:IPR001497" /db_xref="InterPro:IPR008332" /db_xref="InterPro:IPR014048" /db_xref="InterPro:IPR023546" /db_xref="InterPro:IPR036217" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036631" /db_xref="SubtiList:BG10848" /db_xref="UniProtKB/Swiss-Prot:P11742" /translation="MNYYTTAETPLGELIIAEEEDRITRLFLSQEDWVDWKETVQNTE HKETPNLAEAKQQLQEYFAGERKTFSLPLSQKGTPFQQKVWQALERIPYGESRSYADI AAAVGSPKAVRAVGQANKRNDLPIFVPCHRVIGKNSALTGYAGSKTEIKAFLLNIERI SYKEK*" /label="ogt CDS" gene 1302621..1303118 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /label="ogt gene" S_feature 1303119..1303358 /Source="Nicolas_S_feature" /locus_tag="new_1421924_1422163" /HighExp="Lbstat, S2, BT, BC, LPhT, dia15, LBGstat, M0t90, M9-stat, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.981549" /TUshortSig="SigA, SigH" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S485" CDS 1303208..1303333 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513954.1" /translation="MKPSRSEKLAVFAELFVKLHILSSAQKDEIINVNKKKQKNR*" /label="hypothetical protein CDS" gene 1303208..1303333 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /label="gene" downshifts 1303326 /Source="Nicolas_upshifts" /id="D744" /incds=0 /nref=80 /ntot=239 /MaxReadThrough="1.90528" /MaxDrop="5.2481" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1303367..1304428) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /EC_number="5.3.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14551435, 15102328, 16511105, 17690466, 18156470" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14551435, 15102328, 16511105, 17690466, 18156470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose-1-phosphate isomerase (methionine salvage pathway)" /protein_id="NP_389238.1" /db_xref="EnsemblGenomes-Gn:BSU13550" /db_xref="EnsemblGenomes-Tr:CAB13228" /db_xref="GOA:O31662" /db_xref="InterPro:IPR000649" /db_xref="InterPro:IPR005251" /db_xref="InterPro:IPR011559" /db_xref="InterPro:IPR027363" /db_xref="PDB:2YRF" /db_xref="PDB:2YVK" /db_xref="SubtiList:BG13278" /db_xref="UniProtKB/Swiss-Prot:O31662" /translation="MTHSFAVPRSVEWKETAITILNQQKLPDETEYLELTTKEDVFDA IVTLKVRGAPAIGITAAFGLALAAKDIETDNVTEFRRRLEDIKQYLNSSRPTAINLSW ALERLSHSVENAISVNEAKTNLVHEAIQIQVEDEETCRLIGQNALQLFKKGDRIMTIC NAGSIATSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLI TDSMAAHTMKEKQISAVIVGADRIAKNGDTANKIGTYGLAILANAFDIPFFVAAPLST FDTKVKCGADIPIEERDPEEVRQISGVRTAPSNVPVFNPAFDITPHDLISGIITEKGI MTGNYEEEIEQLFKGEKVH*" /label="mtnA CDS" gene complement(1303367..1304428) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /label="mtnA gene" downshifts complement(1303384) /Source="Nicolas_upshifts" /id="D745" /incds=0 /nref=261 /ntot=286 /MaxReadThrough="4.47312" /MaxDrop="7.97339" /score="34.04363" /energy="-17.1" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(1304436..1305629) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /EC_number="2.7.1.100" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:210167, 11545674, 15102328, 17522047, 23649237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 210167, 11545674, 15102328, 17522047, 23649237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose kinase (methionine salvage pathway, promiscuous)" /protein_id="NP_389239.2" /db_xref="EnsemblGenomes-Gn:BSU13560" /db_xref="EnsemblGenomes-Tr:CAB13229" /db_xref="GOA:O31663" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR009212" /db_xref="InterPro:IPR011009" /db_xref="PDB:2OLC" /db_xref="PDB:2PU8" /db_xref="PDB:2PUI" /db_xref="PDB:2PUL" /db_xref="PDB:2PUN" /db_xref="PDB:2PUP" /db_xref="SubtiList:BG13279" /db_xref="UniProtKB/Swiss-Prot:O31663" /translation="MGVTKTPLYETLNESSAVALAVKLGLFPSKSTLTCQEIGDGNLN YVFHIYDQEHDRALIIKQAVPYAKVVGESWPLTIDRARIESSALIRQGEHVPHLVPRV FYSDTEMAVTVMEDLSHLKIARKGLIEGENYPHLSQHIGEFLGKTLFYSSDYALEPKV KKQLVKQFTNPELCDITERLVFTDPFFDHDTNDFEEELRPFVEKLWNNDSVKIEAAKL KKSFLTSAETLIHGDLHTGSIFASEHETKVIDPEFAFYGPIGFDVGQFIANLFLNALS RDGADREPLYEHVNQVWETFEETFSEAWQKDSLDVYANIDGYLTDTLSHIFEEAIGFA GCELIRRTIGLAHVADLDTIVPFDKRIGRKRLALETGTAFIEKRSEFKTITDVIELFK LLVKE*" /label="mtnK CDS" gene complement(1304436..1305629) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /label="mtnK gene" downshifts 1304496 /Source="Nicolas_upshifts" /id="D746" /incds=1 /nref=1 /ntot=51 /MaxReadThrough="3.02938" /MaxDrop="3.49719" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin=1166 /isTUend="FALSE" /label="downshifts" downshifts complement(1305716) /Source="Nicolas_upshifts" /id="D747" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="8.61071" /MaxDrop="3.05641" /score="27.7981655" /energy="-17.6" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-2750" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1305722..1305878) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="12: Regulatory functions" /label="mswC RNA" gene complement(1305722..1305878) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /label="mswC gene" promotor_-10 complement(1305913..1305932) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1305914) /Source="Nicolas_upshifts" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1305948..1305955) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1305958..1305961 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1305962..1306741) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /EC_number="3.5.1.3" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12022921, 19464248, 19596042, 21288482, 23944997, 24387040; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ketoglutaramate omega-amidase" /protein_id="NP_389240.1" /db_xref="EnsemblGenomes-Gn:BSU13570" /db_xref="EnsemblGenomes-Tr:CAB13230" /db_xref="GOA:O31664" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG13280" /db_xref="UniProtKB/Swiss-Prot:O31664" /translation="MKWTISCLQFDISYGKPSENIKKAEFFIEKESKHADVLVLPELW TTGYDLANLDELADEDGRSAQSWLKKTAKKHGVHIVAGSVAVRKNSDVYNTMYIADKE GQIIKEYRKAHLFQLMDEHLYLSAGSEDGYFELDGVKSSGLICYDIRFPEWIRKHTTK GANVLFISAEWPLPRLDHWKSLLIARAIENQCFVAACNCTGSNPDNEFAGHSLIIDPW GRVLAEGGREEGIVRAEIDLQESAEVRESIPVFDDIRKDLY*" /label="mtnU CDS" gene complement(1305962..1306741) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /label="mtnU gene" promotor_-10 1305977..1305996 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1305986 /Source="Nicolas_upshifts" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1306434..1306441 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-35" promotor_-10 1306454..1306473 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-10" upshifts 1306469 /Source="Nicolas_upshifts" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="upshifts" S_feature 1306476..1306793 /Source="Nicolas_S_feature" /locus_tag="new_1425281_1425598" /HighExp="LoTm, S8, C30, BC, S7, B36, B60, T2.0H, Sw, UNK1" /AntisenseName="mtnU" /AntisenseCor="0.77659263363209297" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S486" promotor_-35 1306763..1306770 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1306771..1306790) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1306785..1306804 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1306785) /Source="Nicolas_upshifts" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="upshifts" upshifts 1306795 /Source="Nicolas_upshifts" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1306806..1306813) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1306836..1308032 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /EC_number="2.6.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15102328, 23429746, 24387040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15102328, 23429746, 24387040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine-glutamine aminotransferase" /protein_id="NP_389241.1" /db_xref="EnsemblGenomes-Gn:BSU13580" /db_xref="EnsemblGenomes-Tr:CAB13231" /db_xref="GOA:O31665" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13281" /db_xref="UniProtKB/Swiss-Prot:O31665" /translation="MKFEQSHVLKELPKQFFASLVQKVNRKLAEGHDVINLGQGNPDQ PTPEHIVEEMKRAVADPENHKYSSFRGSYRLKSAAAAFYKREYGIDLDPETEVAVLFG GKAGLVELPQCLLNPGDTILVPDPGYPDYWSGVTLAKAKMEMMPLVKDRAFLPDYSSI TAEIREQAKLMYLNYPNNPTGAVATSEFFEDTVRFAAENGICVVHDFAYGAVGFDGCK PLSFLQTEGAKDIGIEIYTLSKTYNMAGWRVGFAVGNASVIEAINLYQDHMFVSLFRA TQEAAAEALLADQTCVAEQNARYESRRNAWITACREIGWDVTAPAGSFFAWLPVPEGY TSEQFSDLLLEKANVAVAAGNGFGEYGEGYVRVGLLTSEERLKEAAYRIGKLNLFTQK SIDKTL*" /label="mtnE CDS" gene 1306836..1308032 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /label="mtnE gene" promotor_-35 1308014..1308021 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1308036..1308055 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1308055 /Source="Nicolas_upshifts" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1308071..1308171 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="16.3: Control" /label="mswD RNA" gene 1308071..1308171 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /label="mswD gene" downshifts 1308170 /Source="Nicolas_upshifts" /id="D748" /incds=0 /nref=49 /ntot=190 /MaxReadThrough="7.27369" /MaxDrop="4.19981" /score="-1.80590532" /energy="-10.7" /TU="U1103,U1104" /idTUdmin="U1101" /TUdmin=110 /isTUend="FALSE" /label="downshifts" CDS 1308256..1309473 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /EC_number="5.3.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 16737967, 18403380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 16737967, 18403380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2,3-diketo-5-methylthiopentyl-1-phosphate enolase (DK-MTP-1-P enolase)" /protein_id="NP_389242.2" /db_xref="EnsemblGenomes-Gn:BSU13590" /db_xref="EnsemblGenomes-Tr:CAB13232" /db_xref="GOA:O31666" /db_xref="InterPro:IPR000685" /db_xref="InterPro:IPR017443" /db_xref="InterPro:IPR017717" /db_xref="InterPro:IPR033966" /db_xref="InterPro:IPR036376" /db_xref="InterPro:IPR036422" /db_xref="PDB:2ZVI" /db_xref="SubtiList:BG13282" /db_xref="UniProtKB/Swiss-Prot:O31666" /translation="MSELLATYLLTEPGADTEKKAEQIATGLTVGSWTDLPLVKQEQM QKHKGRVIKVEEREGTAASEKQAVITIAYPEINFSQDIPALLTTVFGKLSLDGKIKLI DLHFSEAFKRALPGPKFGVYGIRKLLGEFERPLLMSIFKGVIGRDLSDIKEQLRQQAL GGVDLIKDDEIFFETGLAPFETRIAEGKQILKETYEQTGHKTLYAVNLTGRTADLKDK ARRAAELGADALLFNVFAYGLDVMQGLAEDPEIPVPIMAHPAVSGAFTSSPFYGFSHA LLLGKLNRYCGADFSLFPSPYGSVALPRADALAIHEECVREDAFNQTFAVPSAGIHPG MVPLLMRDFGIDHIINAGGGVHGHPNGAQGGGRAFRAIIDAVLEAQPIDEKAEQCKDL KLALDKWGKAEAV*" /label="mtnW CDS" gene 1308256..1309473 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /label="mtnW gene" CDS 1309470..1310177 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /EC_number="3.1.3.87" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 17654724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 17654724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphatephosphatase (HK-MTPenyl-1-P phosphatase)" /protein_id="NP_389243.1" /db_xref="EnsemblGenomes-Gn:BSU13600" /db_xref="EnsemblGenomes-Tr:CAB13233" /db_xref="GOA:O31667" /db_xref="InterPro:IPR006384" /db_xref="InterPro:IPR017718" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:2FEA" /db_xref="SubtiList:BG13283" /db_xref="UniProtKB/Swiss-Prot:O31667" /translation="MTTRKPFIICDFDGTITMNDNIINIMKTFAPPEWMALKDGVLSK TLSIKEGVGRMFGLLPSSLKEEITSFVLEDAKIREGFREFVAFINEHEIPFYVISGGM DFFVYPLLEGIVEKDRIYCNHASFDNDYIHIDWPHSCKGTCSNQCGCCKPSVIHELSE PNQYIIMIGDSVTDVEAAKLSDLCFARDYLLNECREQNLNHLPYQDFYEIRKEIENVK EVQEWLQNKNAGESSLK*" /label="mtnX CDS" gene 1309470..1310177 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /label="mtnX gene" CDS 1310135..1310764 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /EC_number="4.2.1.109" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 18391471, 23285211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 18391471, 23285211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)" /protein_id="NP_389244.1" /db_xref="EnsemblGenomes-Gn:BSU13610" /db_xref="EnsemblGenomes-Tr:CAB13234" /db_xref="GOA:O31668" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR017714" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG13284" /db_xref="UniProtKB/Swiss-Prot:O31668" /translation="MAAKQERWRELAEVKRELAERDWFPATSGNLSIKVTDEPLTFLV TASGKDKRKETVEDFLLVDQNGEPAESGHSLKPSAETLLHTHLYNKTNAGCCLHVHTV NNNVISELYGDQKKITFKGQEIIKALGLWEENAEVTVPIIENPAHIPTLAALFAEEIS EDSGAVLIRNHGITAWGKTAFEAKRVLEAYEFLFSYHLKLKTLEHQLVK*" /label="mtnB CDS" gene 1310135..1310764 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /label="mtnB gene" CDS 1310779..1311315 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /EC_number="1.13.11.54" /EC_number="1.13.11.53" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acireductone dioxygenase (Ni2+ or Fe2+-requiring)" /protein_id="NP_389245.1" /db_xref="EnsemblGenomes-Gn:BSU13620" /db_xref="EnsemblGenomes-Tr:CAB13235" /db_xref="GOA:O31669" /db_xref="InterPro:IPR004313" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR023956" /db_xref="SubtiList:BG13285" /db_xref="UniProtKB/Swiss-Prot:O31669" /translation="MATIRIHDEANTTIENQEEVASFLDSQEVIYEQWDITRLPEHLS EKYDLTEEEKQQILDTFETEIKDISTRRGYKAQDVISLSDSNPKLDELLENFKREHHH TDDEVRFIVSGHGIFVIQGQDGTFFDVRLNPGDLISVPENIRHYFTLQEDRKVVAVRI FVTTEGWVPIYEKDSVNQ*" /label="mtnD CDS" gene 1310779..1311315 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /label="mtnD gene" S_feature complement(1311162..1311355) /Source="Nicolas_S_feature" /locus_tag="new_1429967_1430160_c" /HighExp="Lbstat, Cold, LBGstat, T0.30H, M9-stat, B60, ferm, T1.30H, LPhT, M0t90" /AntisenseName="mtnD" /AntisenseCor="-0.31139057410816301" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S487" downshifts 1311315 /Source="Nicolas_upshifts" /id="D749" /incds=0 /nref=179 /ntot=227 /MaxReadThrough="1.58976" /MaxDrop="6.10661" /score="35.4563733" /energy="-14.9" /TU="NA" /idTUdmin="U1103" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1311356..1311676) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389246.1" /db_xref="EnsemblGenomes-Gn:BSU13630" /db_xref="EnsemblGenomes-Tr:CAB13236" /db_xref="GOA:O31670" /db_xref="InterPro:IPR010652" /db_xref="SubtiList:BG13308" /db_xref="UniProtKB/Swiss-Prot:O31670" /translation="MKKKKAIMLGAAGGKAILKRKNRKKCIQHITTFFQMLRDWRNGD YPRSQVKTLLLLTAAILYIVMPLDIIPDVILGLGFIDDAAVLGLIWTLIKKELSQYEK WRLQ*" /label="ykvA CDS" gene complement(1311356..1311676) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /label="ykvA gene" downshifts complement(1311414) /Source="Nicolas_upshifts" /id="D750" /incds=0 /nref=5 /ntot=148 /MaxReadThrough="4.05831" /MaxDrop="2.74575" /score="18.5455371" /energy="-11.3" /TU="U1106" /idTUdmin="U1106" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" S_feature complement(1311677..1311766) /Source="Nicolas_S_feature" /locus_tag="new_1430482_1430571_c" /HighExp="Lbstat, M9-stat, B60, T0.30H, LBGstat, M0t90, T1.0H, S2, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S488" promotor_-35 1311702..1311708 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1311723..1311741 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1311733 /Source="Nicolas_upshifts" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="upshifts" S_feature 1311734..1311818 /Source="Nicolas_S_feature" /locus_tag="new_1430539_1430623" /HighExp="Etha, Gly, BC, Salt, Sw, B60, LoTm, M9-stat, LPhT, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S489" promotor_-10 complement(1311748..1311767) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1311765) /Source="Nicolas_upshifts" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1311782..1311785) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1311792..1311799 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1311814..1311833 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1311820..1311878 /Source="Nicolas_S_feature" /locus_tag="new_1430625_1430683" /HighExp="Etha, Gly, Sw, BC, LoTm, B36, T3.30H, Salt, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S490" upshifts 1311820 /Source="Nicolas_upshifts" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1311876) /Source="Nicolas_upshifts" /id="D751" /incds=0 /nref=3 /ntot=61 /MaxReadThrough="0.87927" /MaxDrop="3.53961" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1106" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS 1311879..1312136 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15057450, 15916600, 17001075, 19332814, 22524514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15057450, 15916600, 17001075, 19332814, 22524514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="negative regulatory phosphatase acting on Spo0A-P (sporulation)" /protein_id="NP_389247.1" /db_xref="EnsemblGenomes-Gn:BSU13640" /db_xref="EnsemblGenomes-Tr:CAB13237" /db_xref="GOA:P05043" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG10769" /db_xref="UniProtKB/Swiss-Prot:P05043" /translation="MGGSSEQERLLVSIDEKRKLMIDAARKQGFTGHDTIRHSQELDC LINEYHQLMQENEHSQGIQGLVKKLGLWPRRDVMPAYDANK*" /label="spo0E CDS" gene 1311879..1312136 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /label="spo0E gene" downshifts 1312130 /Source="Nicolas_upshifts" /id="D752" /incds=0 /nref=7 /ntot=169 /MaxReadThrough="4.39402" /MaxDrop="3.59614" /score="0.224700481" /energy="-5.9" /TU="U1105,U1107" /idTUdmin="U1105" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS 1312222..1312653 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative small membrane protein" /protein_id="NP_389248.1" /db_xref="EnsemblGenomes-Gn:BSU13650" /db_xref="EnsemblGenomes-Tr:CAB13238" /db_xref="GOA:P06630" /db_xref="SubtiList:BG10770" /db_xref="UniProtKB/Swiss-Prot:P06630" /translation="MKELAILITEMVNQFHDAFISLCGIFGIHLTDKEMHFWVIGIFG IFFFGVTHAVFTWLSKWSMTALSFIYTVTVIIVIVFAIEIQQKVTGRGNMEFLDATEG IKGFLVFFMFFLLLKMLLRFIKILFSGRPASKSNGNARSRR*" /label="eag CDS" gene 1312222..1312653 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /label="eag gene" CDS complement(1312681..1314201) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" /EC_number="2.7.13.3" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine kinase phosphorylating Spo0A" /protein_id="NP_389249.1" /db_xref="EnsemblGenomes-Gn:BSU13660" /db_xref="EnsemblGenomes-Tr:CAB13239" /db_xref="GOA:O31671" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4JGO" /db_xref="PDB:4JGP" /db_xref="PDB:4JGQ" /db_xref="PDB:4JGR" /db_xref="SubtiList:BG13309" /db_xref="UniProtKB/Swiss-Prot:O31671" /translation="MLERCKLKILKGACGRVKLYIILVVIPAIVISFFVYEKEKDTIA AEHKQEASVLLNLHRNKINYLIGETMARMTSLSIAIDRPVDIKKMQSILEKTFDSEPR FSGLYFLNAKGDVTASTTELKTKVNLADRSFFIKAKETKKTVISDSYSSRITGQPIFT ICVPVLDSKRNVTDYLVAAIQIDYLKNLINLLSPDVYIEVVNQDGKMIFASGQASHAE DQKPVSGYLDDISWNMKVYPNPVTIEELSKSLVLPLSCIIVLLNILFILVLYYLLKRQ TQLERSENEAQKLELIGTLAASTAHEIRNPLTGISGFIQLLQKKYKGEEDQLYFSIIE QEIKRINQIVSEFLVLGKPTAEKWELNSLQDIIGEIMPIIYSEGNLYNVEVELQYLTE QPLLVKCTKDHIKQVILNVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQE MLDHIFLPFVTSKEKGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLPVSAS*" /label="kinD CDS" gene complement(1312681..1314201) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" /label="kinD gene" downshifts complement(1312693) /Source="Nicolas_upshifts" /id="D753" /incds=0 /nref=106 /ntot=227 /MaxReadThrough="0.62895" /MaxDrop="5.24795" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1109" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 1313402..1313408 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1313422..1313433 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1313428 /Source="Nicolas_upshifts" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1314209..1314228) /Source="Nicolas_upshift_promotors" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1314230) /Source="Nicolas_upshifts" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1314328..1314335 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1314350..1314369 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1314352 /Source="Nicolas_upshifts" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="upshifts" CDS 1314394..1314831 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17725564, 17962296, 18282125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17725564, 17962296, 18282125; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family)" /protein_id="NP_389250.1" /db_xref="EnsemblGenomes-Gn:BSU13670" /db_xref="EnsemblGenomes-Tr:CAB13240" /db_xref="GOA:O31672" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13310" /db_xref="UniProtKB/Swiss-Prot:O31672" /translation="MTEKSLKLFIVLSRAYRSINDHMNKHIHKHGLNPTEFAVLELLY HKGDQPLQQIGDKILLASGSITYVVDKLEQKELLIRKASPTDRRVTFAQITEKGIGLL NDIFPDHAAEIDEMISVLSEEEVEMCTEMLKRVGLNAKQFHNK*" /label="mhqR CDS" gene 1314394..1314831 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" /label="mhqR gene" downshifts 1314814 /Source="Nicolas_upshifts" /id="D754" /incds=0 /nref=210 /ntot=257 /MaxReadThrough="1.20686" /MaxDrop="5.47215" /score="1.59181784" /energy="-8.9" /TU="U1110" /idTUdmin="U1110" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1314871..1315656) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein B; MotB component of the H+-coupled stator flagellum complex" /protein_id="NP_389251.1" /db_xref="EnsemblGenomes-Gn:BSU13680" /db_xref="EnsemblGenomes-Tr:CAB13241" /db_xref="GOA:P28612" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10689" /db_xref="UniProtKB/Swiss-Prot:P28612" /translation="MARKKKKKHEDEHVDESWLVPYADILTLLLALFIVLYASSSIDA AKFQMLSKSFNEVFTGGTGVLDYSSVTPPENESDGIDEVKKEKEEKEKNKKEKEKAAD QEELENVKSQVEKFIKDKKLEHQLETKMTSEGLLITIKDSIFFDSGKATIRKEDVPLA KEISNLLVINPPRNIIISGHTDNMPIKNSEFQSNWHLSVMRAVNFMGLLIENPKLDAK VFSAKGYGEYKPVASNKTAEGRSKNRRVEVLILPRGAAETNEK*" /label="motB CDS" gene complement(1314871..1315656) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" /label="motB gene" downshifts complement(1314890) /Source="Nicolas_upshifts" /id="D755" /incds=0 /nref=224 /ntot=246 /MaxReadThrough="3.05351" /MaxDrop="6.69306" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts complement(1315352) /Source="Nicolas_upshifts" /id="D756" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="8.03566" /MaxDrop="4.69358" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" CDS complement(1315628..1316440) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein A; MotA component of the H+-coupled stator flagellum complex" /protein_id="NP_389252.1" /db_xref="EnsemblGenomes-Gn:BSU13690" /db_xref="EnsemblGenomes-Tr:CAB13242" /db_xref="GOA:P28611" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10688" /db_xref="UniProtKB/Swiss-Prot:P28611" /translation="MDKTSLIGIILAFVALSVGMVLKGVSFSALANPAAILIIIAGTI SAVVIAFPTKEIKKVPTLFRVLFKENKQLTIEELIPMFSEWAQLARREGLLALEASIE DVDDAFLKNGLSMAVDGQSAEFIRDIMTEEVEAMEDRHQAGAAIFTQAGTYAPTLGVL GAVIGLIAALSHMDNTDELGHAISAAFVATLLGIFTGYVLWHPFANKLKRKSKQEVKL REVMIEGVLSVLEGQAPKVIEQKLLMYLPAKDRLKFAEQGEAQNGEKKEEEA*" /label="motA CDS" gene complement(1315628..1316440) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" /label="motA gene" promotor_-10 complement(1316471..1316489) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1316487) /Source="Nicolas_upshifts" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1316503..1316510) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1316578..1316800) /Source="Nicolas_S_feature" /locus_tag="new_1435383_1435605_c" /HighExp="Diami, dia15, dia5, Heat, Etha, LPhT, H2O2, C30, G135, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.93062599999999995" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S491" downshifts complement(1316610) /Source="Nicolas_upshifts" /id="D757" /incds=0 /nref=5 /ntot=12 /MaxReadThrough="0.48394" /MaxDrop="4.60081" /score="30.9355071" /energy="-15.4" /TU="NA" /idTUdmin="U1112" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1316823..1318922) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease (class III stress gene)" /protein_id="NP_389253.1" /db_xref="EnsemblGenomes-Gn:BSU13700" /db_xref="EnsemblGenomes-Tr:CAB13243" /db_xref="GOA:O31673" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="SubtiList:BG12578" /db_xref="UniProtKB/Swiss-Prot:O31673" /translation="MRCQHCHQNEATIRLNMQINSVHKQMVLCETCYNELTRKPSMSM GPQSFGFPFEQAFQPKEQSAAKQSEKKGLLDELAQNITNGAKAGLIDPVIGRDDEVAR VIEILNRRNKNNPVLIGEPGVGKTAIAEGLALKIAEGDVPNKLKNKELYLLDVASLVA NTGIRGQFEERMKQLITELKERKNVILFIDEIHLLVGAGSAEGSMDAGNILKPALARG ELQVIGATTLKEYRQIEKDAALERRFQPVMVQEPSIEQAILILQGIKDKYEAYHGVTF SDEAIKACVTLSSRYIQDRHLPDKAIDLLDEAGSKANLLIDELNDEDAAERLTAIEAE KTKALEEENYELAAKLRDEELALEKKLNSSSAHTAVTVEAEHIQEIVEQKTGIPVGKL QADEQTKMKELEAKLHERVIGQEAAVQKVAKAVRRSRAGLKSKNRPVGSFLFVGPTGV GKTELSKTLADELFGTKDAIIRLDMSEYMEKHAVSKIIGSPPGYVGHEEAGQLTEKVR RNPYSIVLLDEIEKAHPDVQHMFLQIMEDGRLTDSQGRTVSFKDTVIIMTSNAGAGEK QTKVGFQSDDSVIEEQTLIDSLSMFFKPEFLNRFDSIIEFRSLEKEHLVKIVSLLLGE LEETLAERGISLNVTDEAKEKIAELGYHPSFGARPLRRTIQEWVEDEMTDLLLDNGEI TSFHVILEDDKIKVRAK*" /label="clpE CDS" gene complement(1316823..1318922) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /label="clpE gene" downshifts complement(1316845) /Source="Nicolas_upshifts" /id="D758" /incds=0 /nref=27 /ntot=132 /MaxReadThrough="4.1802" /MaxDrop="6.07862" /score="41.2563375" /energy="-13.6" /TU="U1112" /idTUdmin="U1112" /TUdmin="-239" /isTUend="FALSE" /label="downshifts" S_feature complement(1318923..1319173) /Source="Nicolas_S_feature" /locus_tag="new_1437728_1437978_c" /HighExp="dia5, Heat, Diami, LPhT, dia15, H2O2, HiTm, S2, Cold, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S492" promotor_no_box complement(1319133..1319233) /Source="Nicolas_upshift_promotors" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1319173) /Source="Nicolas_upshifts" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1319209..1319214 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1319224 /Source="Nicolas_upshifts" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1319230..1319248 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1319287..1320330 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389254.1" /db_xref="EnsemblGenomes-Gn:BSU13710" /db_xref="EnsemblGenomes-Tr:CAB13244" /db_xref="GOA:O31674" /db_xref="SubtiList:BG13311" /db_xref="UniProtKB/Swiss-Prot:O31674" /translation="MEQSKGSASQLAFVYVGTVVGAGFATGREIVEFFLKFGWFGFFG ILVSGGMFTLLGAKLMIISKRINAKSYQEMNIFLFGATAGRIINVFMLFVLLGVTSVM LSGAGALFEEQLGMSAQIGMLITIGLSLIVMTRGVKGIFGVNVFVVPLLIIFSMIVVA DSFIFSESRNAAQWVWPHRWDWLLSAVSYGALNLSLAQAVLVPLANEMSSEKVIKKGA LIGGTMLTIVLSASFLSLSTLPDVFLYDIPMAQVVYLFARSVHLIYLLIIFGEVFTSV IGNLYGLEKQVQSFLPVKSKYIFAAIMITAYITSQIGYGRLISTIYPLFGYVSLAFIG ALLCKKAPRRRSL*" /label="ykvI CDS" gene 1319287..1320330 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /label="ykvI gene" S_feature 1320331..1320422 /Source="Nicolas_S_feature" /locus_tag="new_1439136_1439227" /HighExp="S3, LoTm, S4, S5, BT, M9-stat, S6, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S493" promotor_-35 1320399..1320403 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1320420..1320439 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1320424 /Source="Nicolas_upshifts" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1320469..1320513 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /product="preQ1 riboswitch" /experiment="publication(s) with functional evidences, PMID:17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311; Product type n: RNA" /function="16.3: Control" /label="qswA RNA" gene 1320469..1320513 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /label="qswA gene" downshifts 1320490 /Source="Nicolas_upshifts" /id="D759" /incds=0 /nref=11 /ntot=17 /MaxReadThrough="7.29177" /MaxDrop="4.09959" /score="21.1398563" /energy="-9.5" /TU="U1114" /idTUdmin="U1113" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1320535..1320642 /Source="Nicolas_S_feature" /locus_tag="new_1439340_1439447" /HighExp="Paraq, ferm, G180, LBGstat, Diami, H2O2, LPhT, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S494" CDS 1320643..1321302 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /EC_number="6.3.4.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14660578, 16199558, 17384645, 18491386, 19354300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14660578, 16199558, 17384645, 18491386, 19354300; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pre-queuosine 0 synthase" /protein_id="NP_389255.1" /db_xref="EnsemblGenomes-Gn:BSU13720" /db_xref="EnsemblGenomes-Tr:CAB13245" /db_xref="GOA:O31675" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018317" /db_xref="PDB:3BL5" /db_xref="SubtiList:BG13312" /db_xref="UniProtKB/Swiss-Prot:O31675" /translation="MKKEKAIVVFSGGQDSTTCLLWALKEFEEVETVTFHYNQRHSQE VEVAKSIAEKLGVKNHLLDMSLLNQLAPNALTRNDIEIEVKDGELPSTFVPGRNLVFL SFASILAYQIGARHIITGVCETDFSGYPDCRDEFVKSCNVTVNLAMEKPFVIHTPLMW LNKAETWKLADELGALDFVKNNTLTCYNGIIADGCGECPACHLRSKGYEEYMVMKGER A*" /label="queC CDS" gene 1320643..1321302 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /label="queC gene" CDS 1321295..1321744 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /EC_number="4.1.2.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 18259064, 19231875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 18259064, 19231875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-carboxy-5,6,7,8-tetrahydropterin synthase; queuosine biosynthesis" /protein_id="NP_389256.1" /db_xref="EnsemblGenomes-Gn:BSU13730" /db_xref="EnsemblGenomes-Tr:CAB13246" /db_xref="GOA:O31676" /db_xref="InterPro:IPR007115" /db_xref="SubtiList:BG13313" /db_xref="UniProtKB/Swiss-Prot:O31676" /translation="MHKLLSQIYPQAQHPYSFELNKDMHISAAHFIPRESAGACSRVH GHTYTVNITVAGDELDDSGFLVNFSVLKKLVHGNYDHTLLNDHEDFSQDDRYSLPTTE VVAKTIYDNVQAYLDTLENKPTCVQVFVRETPTSYCVYRPKKGGLNG*" /label="queD CDS" gene 1321295..1321744 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /label="queD gene" CDS 1321737..1322468 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /EC_number="4.3.99.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 19354300, 23194065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 19354300, 23194065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-carboxy-7-deazaguanine synthase" /protein_id="NP_389257.1" /db_xref="EnsemblGenomes-Gn:BSU13740" /db_xref="EnsemblGenomes-Tr:CAB13247" /db_xref="GOA:O31677" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR017742" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR024924" /db_xref="PDB:5TGS" /db_xref="PDB:5TH5" /db_xref="SubtiList:BG13314" /db_xref="UniProtKB/Swiss-Prot:O31677" /translation="MAKGIPVLEIFGPTIQGEGMVIGQKTMFVRTAGCDYSCSWCDSA FTWDGSAKKDIRWMTAEEIFAELKDIGGDAFSHVTISGGNPALLKQLDAFIELLKENN IRAALETQGTVYQDWFTLIDDLTISPKPPSSKMVTNFQKLDHILTSLQENDRQHAVSL KVVIFNDEDLEFAKTVHKRYPGIPFYLQVGNDDVHTTDDQSLIAHLLGKYEALVDKVA VDAELNLVRVLPQLHTLLWGNKRGV*" /label="queE CDS" gene 1321737..1322468 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /label="queE gene" CDS 1322486..1322983 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /EC_number="1.7.1.13" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent 7-cyano-7-deazaguanine reductase" /protein_id="NP_389258.1" /db_xref="EnsemblGenomes-Gn:BSU13750" /db_xref="EnsemblGenomes-Tr:CAB13248" /db_xref="GOA:O31678" /db_xref="InterPro:IPR016856" /db_xref="InterPro:IPR029500" /db_xref="PDB:4F8B" /db_xref="PDB:4FGC" /db_xref="PDB:5UDG" /db_xref="SubtiList:BG13315" /db_xref="UniProtKB/Swiss-Prot:O31678" /translation="MTTRKESELEGVTLLGNQGTNYLFEYAPDVLESFPNKHVNRDYF VKFNCPEFTSLCPKTGQPDFATIYISYIPDEKMVESKSLKLYLFSFRNHGDFHEDCMN IIMNDLIELMDPRYIEVWGKFTPRGGISIDPYTNYGKPGTKYEKMAEYRMMNHDLYPE TIDNR*" /label="queF CDS" gene 1322486..1322983 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /label="queF gene" S_feature 1322984..1323260 /Source="Nicolas_S_feature" /locus_tag="new_1441789_1442065" /HighExp="Paraq, ferm, LPhT, C30, G135, G180, LBGstat, Oxctl, G150, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S495" downshifts 1323218 /Source="Nicolas_upshifts" /id="D760" /incds=0 /nref=200 /ntot=247 /MaxReadThrough="1.17154" /MaxDrop="6.60953" /score="11.1883045" /energy="-7.8" /TU="NA" /idTUdmin="U1114" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1323228) /Source="Nicolas_upshifts" /id="D761" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.54726" /MaxDrop="2.16508" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=110 /isTUend="FALSE" /label="downshifts" S_feature complement(1323297..1323541) /Source="Nicolas_S_feature" /locus_tag="new_1442102_1442346_c" /HighExp="Diami, dia5, LPhT, Etha, Salt, dia15, Heat, HiTm, C30, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15795400000000001" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S496" downshifts complement(1323338) /Source="Nicolas_upshifts" /id="D762" /incds=0 /nref=47 /ntot=193 /MaxReadThrough="2.13712" /MaxDrop="5.08206" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1323542..1323898) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HGT island)" /protein_id="NP_389259.1" /db_xref="EnsemblGenomes-Gn:BSU13760" /db_xref="EnsemblGenomes-Tr:CAB13249" /db_xref="GOA:O31679" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13316" /db_xref="UniProtKB/Swiss-Prot:O31679" /translation="MKKFSCGFEVTKEVIGGKWKGLVLYFLMNGPKRTSELKRIIPNI TQKMLIQTLRELEASGLVSRKMYNQVPPKVEYSSTELGESLKPILQELCQWGGYYAEQ EYAEGEYEIVQPEQLS*" /label="ykvN CDS" gene complement(1323542..1323898) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /label="ykvN gene" misc_feature complement(1323929..1323948) /Source="Nicolas_upshift_promotors" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1323946) /Source="Nicolas_upshifts" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1323983..1324001 /Source="Nicolas_upshift_promotors" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1323988 /Source="Nicolas_upshifts" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="upshifts" CDS 1324067..1324813 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018, 26494135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (HGT island)" /protein_id="NP_389260.1" /db_xref="EnsemblGenomes-Gn:BSU13770" /db_xref="EnsemblGenomes-Tr:CAB13250" /db_xref="GOA:O31680" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13317" /db_xref="UniProtKB/Swiss-Prot:O31680" /translation="MGKFEGKIALVTGGTSGIGLATAQKFVNEGAYVYITGRRQNELD KAVNQIGKNVTGVQGDISKLEDLDKLYDIIKQEKGKLDILFANAGIGNFLPLGEITEE QVDRTFDINVKGTIFTVQKALSLFPDKVGSIIVTGSTAGSIGNPAFSVYGASKAALRA LVRNWILDLKGTEIRVNVVSPGGILTPAYDELFGDALEEVLENSRNTVPAGKVGTPEE VANAVSFLASDESSYLTGVELFVDGGLAQV*" /label="ykvO CDS" gene 1324067..1324813 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /label="ykvO gene" downshifts 1324868 /Source="Nicolas_upshifts" /id="D763" /incds=0 /nref=19 /ntot=146 /MaxReadThrough="0.723690000000001" /MaxDrop="4.37163" /score="1.34631843" /energy="-9.1" /TU="NA" /idTUdmin="U1116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1325216..1325224 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1325238..1325257 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1325242 /Source="Nicolas_upshifts" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="upshifts" CDS 1325294..1326493 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11011148, 16683018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16683018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein (HGT island)" /protein_id="NP_389261.1" /db_xref="EnsemblGenomes-Gn:BSU13780" /db_xref="EnsemblGenomes-Tr:CAB13251" /db_xref="GOA:O31681" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13318" /db_xref="UniProtKB/Swiss-Prot:O31681" /translation="MKILFLESHPMWLYGLPNGFREAGHTVMISGPVSRENITEMIDE FKPDLIVSMGWTPEHSREKQAWIRNATKKVNIPLVYWATEDPLHTQNFTIPLIKKMKP DFVFTVTPSLCKTYESMGIKAAHLDFAFHESIHHQIKPLAKYSCDIAVVANAYPNFLE EHPEVFRSSSLKTLIRPLIRKGIRIDFWGRNWEKMSKYIGREIPRNWIHGYLDYTEAY KVYSSAKIIIGLQNCESQLTQRTYEILGSGGFLLTSDTPAVRGKFKPGRDLIVSSSPK ETLEKVKYYLNHDSERKKIQINGKKAVKNDSYRHRAERMLEVLKSRGIIRNLGETIHY VDVLKEKYVIHHVTPGETLSIIASKYNVSLQQLMELNHFKSDQIYAGQIIKIREKLFR NINNKLF*" /label="ykvP CDS" gene 1325294..1326493 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /label="ykvP gene" promotor_-35 1325376..1325382 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1325397..1325415 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1325403 /Source="Nicolas_upshifts" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1326462..1326464 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1326484..1326502 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1326496 /Source="Nicolas_upshifts" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1326509..1326736 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative peptidoglycan binding protein" /protein_id="YP_003097719.1" /db_xref="EnsemblGenomes-Gn:BSU13789" /db_xref="EnsemblGenomes-Tr:CAX52610" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="UniProtKB/Swiss-Prot:C0H403" /translation="MKGKIPKIRNQANKVKRTPRYMEFPVTYEVYHVESGDTLWTIAK SFEIPVQQLMNLNKLSSDRIYPGQIIKIRER*" /label="ykzQ CDS" gene 1326509..1326736 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /label="ykzQ gene" misc_feature complement(1326586..1326605) /Source="Nicolas_upshift_promotors" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1326594) /Source="Nicolas_upshifts" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1326737..1326832 /Source="Nicolas_S_feature" /locus_tag="new_1445542_1445637" /HighExp="BT, S8, B36, S7, Etha, S6, G/S, LBGstat, Pyr, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigK" /TUshortPSig="0.602, 0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S497" CDS 1326833..1327531 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /EC_number="3.2.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative sporulation-specific glycosylase (HGT island)" /db_xref="EnsemblGenomes-Gn:BSU13790" /db_xref="EnsemblGenomes-Tr:CAB13252" /db_xref="GOA:O31682" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAB13252.1" /db_xref="SubtiList:BG13319" /db_xref="UniProtKB/Swiss-Prot:O31682" /translation="MFQMSYYYSGLGWDFIQHVDQTNGVLNVVSPDFFYIRKDGSLLL RSANPDVIKALHRRKLKVVPFLSNHWDQDLGRFALMNRVLLAKQISHAIEELDLDGVN IDIENLTEKDRNLFTDFIRLVRKSIPRHKEVSVAVAANPFGWTKGWHGSYDYEYLAKY ADYLMVMAYDESRLAGPTASVGWVEKSIQYVLTQKISPQKLVLGLPFYGRCWMEGQSA SQAIPLYLVVSKKA*" /label="ykvQ CDS" gene 1326833..1327531 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /pseudo /label="ykvQ gene" S_feature complement(1327484..1328310) /Source="Nicolas_S_feature" /locus_tag="new_1446289_1447115_c" /HighExp="H2O2, M40t90, S8, M40t45, LPhT, Sw, Cold, LBGstat, C30, dia15" /AntisenseName="ykzR" /AntisenseCor="0.170402182980955" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="0.38670900000000002" /TUshortSig="SigA" /TUshortPSig="0.986" /TUlongSig="NA" /TUlongPSig="NA" /label="S498" CDS 1327512..1327763 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative spore-specific glycosyl hydrolase" /db_xref="EnsemblGenomes-Gn:BSU13799" /db_xref="EnsemblGenomes-Tr:CAX52611" /db_xref="GOA:C0H404" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAX52611.1" /db_xref="UniProtKB/Swiss-Prot:C0H404" /translation="MLVKRHSGTIIFDTKSQSPKAIFTVNHDKKGPLPSGTYTLWFEN EQSLRAKIKLAQKYNLKGLGSWSLGQEDASVWNTVFKNI*" /label="ykzR CDS" gene 1327512..1327763 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /pseudo /label="ykzR gene" misc_feature 1328013..1328028 /Source="Nicolas_upshift_promotors" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1328036..1328247 /Source="Nicolas_S_feature" /locus_tag="new_1446841_1447052" /HighExp="Diami, S8, dia15, G180, HPh, C30, Paraq, H2O2, Salt, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.516" /TUlongSig="NA" /TUlongPSig="NA" /label="S499" upshifts 1328036 /Source="Nicolas_upshifts" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="upshifts" downshifts 1328212 /Source="Nicolas_upshifts" /id="D764" /incds=0 /nref=2 /ntot=72 /MaxReadThrough="2.59168" /MaxDrop="2.74537" /score="-4.38958816" /energy="-9" /TU="NA" /idTUdmin="U1121" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1328299..1328318) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1328321) /Source="Nicolas_upshifts" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1328334..1328341) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1328386..1328393 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1328408..1328427 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1328410 /Source="Nicolas_upshifts" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="upshifts" CDS 1328446..1328736 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="NP_389263.1" /db_xref="EnsemblGenomes-Gn:BSU13800" /db_xref="EnsemblGenomes-Tr:CAB13253" /db_xref="InterPro:IPR021596" /db_xref="InterPro:IPR023105" /db_xref="PDB:2JN9" /db_xref="SubtiList:BG13320" /db_xref="UniProtKB/Swiss-Prot:O31683" /translation="MKTLRLNNVTLEMAAYQEESEPKRKIAFTLNVTSETYHDIAVLL YEKTFNVEVPERDLAFRGEMTNYSTSLTNLYEPGAVSEFYIEITEIDKNADS*" /label="ykvR CDS" gene 1328446..1328736 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /label="ykvR gene" S_feature complement(1328773..1328856) /Source="Nicolas_S_feature" /locus_tag="new_1447578_1447661_c" /HighExp="Etha, dia5, Salt, SMMPr, Lbtran, dia15, Heat, S4, HiOs, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S500" downshifts complement(1328816) /Source="Nicolas_upshifts" /id="D765" /incds=0 /nref=216 /ntot=257 /MaxReadThrough="2.80569" /MaxDrop="6.83857" /score="21.3524751" /energy="-9.9" /TU="U1124" /idTUdmin="U1126" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1328857..1329042) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (HGT island)" /protein_id="NP_389264.2" /db_xref="EnsemblGenomes-Gn:BSU13810" /db_xref="EnsemblGenomes-Tr:CAB13254" /db_xref="InterPro:IPR018690" /db_xref="SubtiList:BG13321" /db_xref="UniProtKB/Swiss-Prot:O31684" /translation="MKIAKVGNVIEFKNGLTGVVEKVNENSVIVDVTIMDNYRDLELD SLTVVNHKNYKIIRDSY*" /label="ykvS CDS" gene complement(1328857..1329042) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /label="ykvS gene" promotor_-10 complement(1329075..1329094) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1329086) /Source="Nicolas_upshifts" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1329088..1329432) /Source="Nicolas_S_feature" /locus_tag="new_1447893_1448237_c" /HighExp="S4, S8, S6, S5, S3, T5.0H, LoTm, S7, T4.0H, BT" /AntisenseName="ykzS" /AntisenseCor="-0.65556958045860303" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S501" promotor_-35 complement(1329108..1329115) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1329141..1329146 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1329162..1329181 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1329169 /Source="Nicolas_upshifts" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="upshifts" CDS 1329208..1329402 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="YP_003097721.1" /db_xref="EnsemblGenomes-Gn:BSU13819" /db_xref="EnsemblGenomes-Tr:CAX52612" /db_xref="UniProtKB/Swiss-Prot:C0H405" /translation="MRPEEITEMIEQLRTGAINELRVQKEHFLDFRAVLSKQDDFKHF RGIAQQGGDVIFQYLEQPRS*" /label="ykzS CDS" gene 1329208..1329402 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /label="ykzS gene" downshifts 1329378 /Source="Nicolas_upshifts" /id="D766" /incds=0 /nref=6 /ntot=124 /MaxReadThrough="3.66738" /MaxDrop="3.03929" /score="5.82604583" /energy="-10.6" /TU="U1125" /idTUdmin="U1123" /TUdmin=682 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1329423..1329441) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1329439) /Source="Nicolas_upshifts" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1329458..1329463) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1329701..1330327 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12177332, 12950927, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall hydrolase related to spore cortex-lytic enzymes" /protein_id="NP_389265.1" /db_xref="EnsemblGenomes-Gn:BSU13820" /db_xref="EnsemblGenomes-Tr:CAB13255" /db_xref="GOA:O31685" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG13322" /db_xref="UniProtKB/Swiss-Prot:O31685" /translation="MTTKFTALAVFLLCFMPAAKIEHTQASLLSAKKTKHEEAKWLTH IDRNTNESFPSLSADKDKKIKPIKLSAHTEKKEKDKPDKTNDEKETYTQSEKELLSRL VHAEAKGESYKGKVAVASVVLNRTEKKGFPDTIRGVIYQKNAFEPVANGSINQKPDKE SIEAAEEALSSKNRETDAIFFYNPKTASDNWIRSRKIVEKIGRHVFAV*" /label="ykvT CDS" gene 1329701..1330327 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /label="ykvT gene" downshifts 1330258 /Source="Nicolas_upshifts" /id="D767" /incds=1 /nref=1 /ntot=17 /MaxReadThrough="0.932830000000001" /MaxDrop="1.92264" /score="9.80914166" /energy="-11.9" /TU="NA" /idTUdmin="U1125" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 1330384..1330389 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1330396 /Source="Nicolas_upshifts" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1330405..1330423 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1330445..1331782 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15686839, 15849754, 16850406, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15686839, 15849754, 16850406, 19648239; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore membrane protein involved in germination" /protein_id="NP_389266.1" /db_xref="EnsemblGenomes-Gn:BSU13830" /db_xref="EnsemblGenomes-Tr:CAB13256" /db_xref="GOA:O31686" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="SubtiList:BG13323" /db_xref="UniProtKB/Swiss-Prot:O31686" /translation="MNRFVKGIILLSIAAFFAECLEFVVNMILARELGEHGMGLYMSI LPTIFLIIVIASLELPISISKFIAESNPKLHESMLRHAFRMTAIFTAFSTAAASIALP FIPVFDTYHPFIKGIVIGLIPVVAFTSIARGYFMGVQKMGKIAIANVLKKIIQLLCLF LFFQWYSFELDMAVLISLFVLVVSDVVVLVYLYSQFIMARRALSGQQHIHLRGKDVRK RLLAVSIPTTGLRIFHAVVNAIEPFLVKGALLAAGVAGTAAIDQYGMLAGVAVTIGSF PAFIAHSLMVVMIPSISEAYALSQYDIVLKRLKQSIFITLGYGIPAVWVMFQFAGPLT HLFFHSPEAQYYLQLLWPYFLFHLFVMPLQACLIGMGFVKEAFYHNVWSHIVALSMMY VLGSMENLQMLGIILGMNTGMILLTSLHYATICKALKVSVFLTGGTRTPRIEG*" /label="ykvU CDS" gene 1330445..1331782 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /label="ykvU gene" CDS 1331833..1332330 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15292147, 15322369, 15342593, 19144642, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292147, 15322369, 15342593, 19144642, 28383125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific thiol-disulfide oxidoreductase (SpoVD maturation)" /protein_id="NP_389267.1" /db_xref="EnsemblGenomes-Gn:BSU13840" /db_xref="EnsemblGenomes-Tr:CAB13257" /db_xref="GOA:O31687" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:3ERW" /db_xref="SubtiList:BG13324" /db_xref="UniProtKB/Swiss-Prot:O31687" /translation="MLTKRLLTIYIMLLGLIAWFPGAAQAEEKQPAVPAVFLMKTIEG EDISIPNKGQKTILHFWTSWCPPCKKELPQFQSFYDAHPSDSVKLVTVNLVNSEQNQQ VVEDFIKANKLTFPIVLDSKGELMKEYHIITIPTSFLLNEKGEIEKTKIGPMTAEQLK EWTEE*" /label="stoA CDS" gene 1331833..1332330 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /label="stoA gene" promotor_-35 1332179..1332185 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1332194 /Source="Nicolas_upshifts" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1332200..1332218 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1332304 /Source="Nicolas_upshifts" /id="D768" /incds=0 /nref=36 /ntot=164 /MaxReadThrough="1.89069" /MaxDrop="4.34947" /score="14.1388498" /energy="-11.3" /TU="NA" /idTUdmin="U1127" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1332425..1332431 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1332442..1332461 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1332454 /Source="Nicolas_upshifts" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1332458..1332565 /Source="Nicolas_S_feature" /locus_tag="new_1451263_1451370" /HighExp="LBGstat, C90, Lbstat, BC, Cold, T0.30H, Etha, Lbtran, LBGtran, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S502" CDS 1332566..1334479 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029044, 12180919, 15802251, 21813502, 26261021, 26566138" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12180919, 15802251, 21813502, 26261021, 26566138; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Fe(II) efflux transporter possibly involved in copper(II) uptake" /protein_id="NP_389268.1" /db_xref="EnsemblGenomes-Gn:BSU13850" /db_xref="EnsemblGenomes-Tr:CAB13258" /db_xref="GOA:O31688" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13325" /db_xref="UniProtKB/Swiss-Prot:O31688" /translation="MNEQVIVQRDPHEPLKTDKREKNWAQHAELIAALVSGALILAGW LLSGYQVLSIILFLLAFVIGGFAKAKEGIEETLESKTLNVELLMIFAAIGSALIGYWA EGAILIFIFSLSGALETYTMNKSSRDLTSLMQLEPEEATLMVNGETKRVPVSDLQAGD MIVIKPGERVAADGIIESGSTSLDESALTGESMPVEKNTGDTVFTGTVNRNGSLTVRV TKANEDSLFRKIIKLVESAQNSVSPAQAFIERFENAYVKGVLIAVALLLFVPHFALGW SWSETFYRAMVFMVVASPCALVASIMPAALSLISNGARNGMLVKGSVFLEQLGSVQMI AFDKTGTVTKGQPAVETIRIAEGFSEAEVLEAVYAIETQSSHPLAQAITAYAESRGVN QSGYISIEETSGFGVMAEVSGAKWKVGKAGFIGEEMAAQFMKQTASDVIQSGHTIVFV KKDDQIAGCIALKDQIRPEAKEVMEELNRLGIKTAMLTGDHEDTAQAIAKEAGMTTVV AECLPDQKVNEIKRLKEEFGTIAMVGDGINDAPALKAADVGIAMGGGTDVALETADMV LMKNDLKKLVNMCRLSRKMNRIIKQNIVFSLAVICLLICANFLQAMELPFGVIGHEGS TILVILNGLRLLK*" /label="pfeT CDS" gene 1332566..1334479 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /label="pfeT gene" promotor_-10 complement(1332715..1332734) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1332732) /Source="Nicolas_upshifts" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1332747..1332756) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1332883..1332902) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1332908) /Source="Nicolas_upshifts" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1332916..1332922) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1334460 /Source="Nicolas_upshifts" /id="D769" /incds=0 /nref=62 /ntot=148 /MaxReadThrough="2.05978" /MaxDrop="6.90668" /score="30.2111295" /energy="-18" /TU="NA" /idTUdmin="U1129" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1334536) /Source="Nicolas_upshifts" /id="D770" /incds=0 /nref=74 /ntot=208 /MaxReadThrough="0.83751" /MaxDrop="4.23141" /score="34.2342147" /energy="-18" /TU="NA" /idTUdmin="U1132" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1334747..1334766) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1334756) /Source="Nicolas_upshifts" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1334780..1334787) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1334831..1334850 /Source="Nicolas_upshift_promotors" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1334841 /Source="Nicolas_upshifts" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="upshifts" CDS 1334886..1335977 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7770058, 23144141" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7770058, 23144141; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Xaa-Pro Xaa-Pro-Xaa di-tri-peptidase used in osmoprotection" /protein_id="NP_389269.1" /db_xref="EnsemblGenomes-Gn:BSU13860" /db_xref="EnsemblGenomes-Tr:CAB13259" /db_xref="GOA:O31689" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG13326" /db_xref="UniProtKB/Swiss-Prot:O31689" /translation="MNRIQRVSSWLKEAGHTAAFIHTKENVFYLTGFYTEPHERLMGL FIFQEEEPFFVCPGMEAGQARNAGWNHEIIGYADHENPWELIEKALKKRNISIHMLAV EKDSISLSRAEQLKHATGGAQFVSAEETLNQFRLIKDDNEIRLLKEAAKLADYGVEVG TAALREGISEVEVLAQIEYELKKKGIQGMSFSTMVLFGEKSGQPHGNPGTATLKKGDF VLFDLGVILDGYCSDITRTFAYKTINPKQEAIYETVLQAEKAAIEASKPGVRIGDLDL TARGIIEKAGYGDYFPHRLGHGLGISVHEYPSMSQANDTLLQEGMVYTIEPGIYVPEI GGVRIEDDVHVTKDGAVALTQYPKDLIIL*" /label="papB CDS" gene 1334886..1335977 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /label="papB gene" downshifts 1335626 /Source="Nicolas_upshifts" /id="D771" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.10599" /MaxDrop="5.06339" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1166 /isTUend="FALSE" /label="downshifts" downshifts 1335956 /Source="Nicolas_upshifts" /id="D772" /incds=0 /nref=2 /ntot=52 /MaxReadThrough="5.66039" /MaxDrop="2.56719" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1496 /isTUend="FALSE" /label="downshifts" S_feature complement(1335990..1336208) /Source="Nicolas_S_feature" /locus_tag="new_1454795_1455013_c" /HighExp="B60, B36, C30, G135, LBGstat, S8, Lbstat, C90, Etha, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.92748200000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S503" S_feature 1336001..1336258 /Source="Nicolas_S_feature" /locus_tag="new_1454806_1455063" /HighExp="dia15, dia5, Etha, M0t90, M40t90, Lbstat, H2O2, G150, Mt0, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S504" promotor_-10 complement(1336195..1336214) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1336208) /Source="Nicolas_upshifts" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1336230..1336237) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1336259..1337224 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LacI family)" /protein_id="NP_389270.1" /db_xref="EnsemblGenomes-Gn:BSU13870" /db_xref="EnsemblGenomes-Tr:CAB13260" /db_xref="GOA:O31690" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13327" /db_xref="UniProtKB/Swiss-Prot:O31690" /translation="MANIKDIAEKAGVSVTTVSRVINNHPYVSEDKRKRVFEAMESLE YTRNIHAVHLSKGFSNMIGVVLPTVNLPYFAELIAGIADAAAESGVHLSLFQTNYEVQ KEIFALSQLKQRQVDGLIFCSKALADEKLMEWEGPILLCQNSDNARFPTISIPHQEAF RNGLDYLIAKGHKKIAICLARKKGMNSHFRIKAYKEALEEIGEAFREDWVIEKAITIN DGKALFHKWNTWKEKPTAIFVANDQVSAGLFLEAKNQRVSVPDELAILSVDNHEISQA LGITTIDIQTREMGKQAFAILEKRIQGQPIERKVLDYRLIERSTV*" /label="ykvZ CDS" gene 1336259..1337224 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /label="ykvZ gene" promotor_-35 1337242..1337249 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-35" promotor_-10 1337264..1337283 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-10" upshifts 1337276 /Source="Nicolas_upshifts" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="upshifts" CDS 1337287..1338153 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10974121, 14527945, 15155854, 17074746, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974121, 14527945, 15155854, 17074746, 22750856; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_389271.2" /db_xref="EnsemblGenomes-Gn:BSU13880" /db_xref="EnsemblGenomes-Tr:CAB13261" /db_xref="GOA:O31691" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:3GWH" /db_xref="PDB:3RIO" /db_xref="PDB:3UFE" /db_xref="SubtiList:BG12593" /db_xref="UniProtKB/Swiss-Prot:O31691" /translation="MTKELRIVNGSFTVKKVLNNNVLIASHHKYSEVVLIGKGIGFGK KQDDVIEDKGYDKMFILKDEKEQKQFKKLLDYVDEKLVDISNDVIYHISNRTNHSLNE HIHIALTDHIAFAIKRQQQGFDMKNPFLMETQSLYPEEYQIAKEVIDMINEKAGLCLP EGEIGFIALHIHSALTNRPLSEVNQHSQLMAQLVEVIEDSFQMKVNKESVNYLRLIRH IRFTIERIKKEEPTKEPEKLMLLLKNEYPLCYNTAWKLIKILQQTLKKPVHEAEAVYL TLHLYRLTNKIS*" /label="glcT CDS" gene 1337287..1338153 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /label="glcT gene" promotor_-35 1338008..1338012 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1338029..1338048 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1338037 /Source="Nicolas_upshifts" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="upshifts" downshifts 1338155 /Source="Nicolas_upshifts" /id="D773" /incds=0 /nref=1 /ntot=30 /MaxReadThrough="9.01653" /MaxDrop="3.09921" /score="-5.18621526" /energy="-6.2" /TU="U1133,U1135,U1136" /idTUdmin="U1135" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_RNA 1338200..1338351 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /product="riboswitch regulating ptsGHI expression via GlcTbinding" /experiment="publication(s) with functional evidences, PMID:15155854, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15155854, 22750856; Product type n: RNA" /label="gswA RNA" S_feature 1338200..1338351 /Source="Nicolas_S_feature" /locus_tag="new_1457005_1457156" /HighExp="LBGexp, G150, C30, G135, G180, MG 90, dia0, Lbexp, dia15, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.988, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S505" gene 1338200..1338351 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /label="gswA gene" promotor_-35 1338329..1338335 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1338349..1338360 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1338353 /Source="Nicolas_upshifts" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="upshifts" CDS 1338382..1340481 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /EC_number="2.7.1.199" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucose-specificenzyme IICBA component" /protein_id="NP_389272.1" /db_xref="EnsemblGenomes-Gn:BSU13890" /db_xref="EnsemblGenomes-Tr:CAB13262" /db_xref="GOA:P20166" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="PDB:1AX3" /db_xref="PDB:1GPR" /db_xref="SubtiList:BG10198" /db_xref="UniProtKB/Swiss-Prot:P20166" /translation="MFKALFGVLQKIGRALMLPVAILPAAGILLAIGNAMQNKDMIQV LHFLSNDNVQLVAGVMESAGQIVFDNLPLLFAVGVAIGLANGDGVAGIAAIIGYLVMN VSMSAVLLANGTIPSDSVERAKFFTENHPAYVNMLGIPTLATGVFGGIIVGVLAALLF NRFYTIELPQYLGFFAGKRFVPIVTSISALILGLIMLVIWPPIQHGLNAFSTGLVEAN PTLAAFIFGVIERSLIPFGLHHIFYSPFWYEFFSYKSAAGEIIRGDQRIFMAQIKDGV QLTAGTFMTGKYPFMMFGLPAAALAIYHEAKPQNKKLVAGIMGSAALTSFLTGITEPL EFSFLFVAPVLFAIHCLFAGLSFMVMQLLNVKIGMTFSGGLIDYFLFGILPNRTAWWL VIPVGLGLAVIYYFGFRFAIRKFNLKTPGREDAAEETAAPGKTGEAGDLPYEILQAMG DQENIKHLDACITRLRVTVNDQKKVDKDRLKQLGASGVLEVGNNIQAIFGPRSDGLKT QMQDIIAGRKPRPEPKTSAQEEVGQQVEEVIAEPLQNEIGEEVFVSPITGEIHPITDV PDQVFSGKMMGDGFAILPSEGIVVSPVRGKILNVFPTKHAIGLQSDGGREILIHFGID TVSLKGEGFTSFVSEGDRVEPGQKLLEVDLDAVKPNVPSLMTPIVFTNLAEGETVSIK ASGSVNREQEDIVKIEK*" /label="ptsG CDS" gene 1338382..1340481 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /label="ptsG gene" promotor_-35 1340499..1340503 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1340519..1340538 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1340530 /Source="Nicolas_upshifts" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="upshifts" CDS 1340579..1340845 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="histidine-containing phosphocarrier protein of the phosphotransferase system (PTS) (HPr protein)" /protein_id="NP_389273.1" /db_xref="EnsemblGenomes-Gn:BSU13900" /db_xref="EnsemblGenomes-Tr:CAB13263" /db_xref="GOA:P08877" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR001020" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1JEM" /db_xref="PDB:1KKL" /db_xref="PDB:1KKM" /db_xref="PDB:1SPH" /db_xref="PDB:2FEP" /db_xref="PDB:2HID" /db_xref="PDB:2HPR" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10200" /db_xref="UniProtKB/Swiss-Prot:P08877" /translation="MAQKTFKVTADSGIHARPATVLVQTASKYDADVNLEYNGKTVNL KSIMGVMSLGIAKGAEITISASGADENDALNALEETMKSEGLGE*" /label="ptsH CDS" gene 1340579..1340845 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /label="ptsH gene" CDS 1340845..1342557 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /EC_number="2.7.3.9" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106335, 11902727, 15155854, 15670601, 25355936, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106335, 11902727, 15155854, 15670601, 25355936, 26159071; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) enzyme I" /protein_id="NP_389274.2" /db_xref="EnsemblGenomes-Gn:BSU13910" /db_xref="EnsemblGenomes-Tr:CAB13264" /db_xref="GOA:P08838" /db_xref="InterPro:IPR000121" /db_xref="InterPro:IPR006318" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR008731" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018274" /db_xref="InterPro:IPR023151" /db_xref="InterPro:IPR024692" /db_xref="InterPro:IPR036618" /db_xref="SubtiList:BG10201" /db_xref="UniProtKB/Swiss-Prot:P08838" /translation="MQELKGIGASAGIAIAKAYRLEEPDLTVEKKNISDSEAEVSRFD EAIARSKEELEKIKEHALKELGQDKADIFSAHLLVLSDPELLNPVKEKISTDSVNAEF ALKETSSMFVTMFESMDNEYMKERAADIRDVTKRVTGHLLGVEIPNPSMISEEVIIVA EDLTPSDTAQLNREFVKGFTTDIGGRTSHSAIMARSLEIPAVVGTKAATGTIQNGVTV IVDGINGDVIIDPSAETVKEYEEKHNAYLAQKAEWAKLVNEPTVSKDGHHVELAANIG TPDDVKGVLENGGEAVGLYRTEFLYMGRDQLPTEDEQFDAYKTVLERMEGKSVVVRTL DIGGDKELPYLQLPKEMNPFLGYRAIRLCLEEQEIFRTQLRALLRASTYGNLKIMFPM IATVNEFKEAKAILLEEKEKLVKAGQAVSDDIEVGMMVEIPSTAVIADQFAKEVDFFS IGTNDLIQYTMAADRMNERVSYLYQPYNPAILRLITLVIEAAHKEGKWVGMCGEMAGD EIAIPILLGLGLDEFSMSATSILPARTQISKLSKQEAESFKEKILSMSTTEEVVAFVK ETFK*" /label="ptsI CDS" gene 1340845..1342557 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /label="ptsI gene" downshifts 1342544 /Source="Nicolas_upshifts" /id="D774" /incds=0 /nref=116 /ntot=277 /MaxReadThrough="5.0255" /MaxDrop="5.64321" /score="21.2608168" /energy="-12.3" /TU="U1136,U1138" /idTUdmin="U1133" /TUdmin=11 /isTUend="TRUE" /label="downshifts" promotor_-35 1342597..1342603 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1342618..1342629 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1342621 /Source="Nicolas_upshifts" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="upshifts" CDS 1342648..1342887 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9009064, 9323362, 10629212" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9009064, 9323362, 10629212; Product type r: regulator" /codon_start=1 /transl_table=11 /product="TRAP-like transcriptional negative regulator of spore photoproduct lyase" /protein_id="NP_389275.1" /db_xref="EnsemblGenomes-Gn:BSU13920" /db_xref="EnsemblGenomes-Tr:CAB13265" /db_xref="GOA:P37955" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG10202" /db_xref="UniProtKB/Swiss-Prot:P37955" /translation="MSNQFNAGDTVYVIYRNPHAANVAHIKEAEIVHHPYHEGELSLF IYETYHPFAEDDAVFASYEEAKSLYKELFDIDPYE*" /label="splA CDS" gene 1342648..1342887 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /label="splA gene" S_feature complement(1342668..1344007) /Source="Nicolas_S_feature" /locus_tag="new_1461473_1462812_c" /HighExp="T4.0H, T3.30H, T3.0H, S3, S1, T2.0H, T2.30H, S2, T5.0H, S4" /AntisenseName="splB" /AntisenseCor="-0.193138593783996" /AntisenseRegPval="-2.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S506" CDS 1342965..1343993 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /EC_number="4.1.99.14" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore photoproduct (thymine dimer) lyase" /protein_id="NP_389276.1" /db_xref="EnsemblGenomes-Gn:BSU13930" /db_xref="EnsemblGenomes-Tr:CAB13266" /db_xref="GOA:P37956" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023897" /db_xref="InterPro:IPR034560" /db_xref="SubtiList:BG10203" /db_xref="UniProtKB/Swiss-Prot:P37956" /translation="MQNPFVPQLVYIEPRALEYPLGQELQDKFENMGIEIRETTSHNQ VRNIPGKNHLQQYRNAKSTLVIGVRKTLKFDSSKPSAEYAIPFATGCMGHCHYCYLQT TMGSKPYIRTYVNVEEILDQADKYMKERAPEFTRFEASCTSDIVGIDHLTHTLKRAIE HFGQSDLGKLRFVTKFHHVDHLLDAKHNGKTRFRFSINADYVIKNFEPGTSPLDKRIE AAVKVAKAGYPLGFIVAPIYIHEGWEEGYRHLFEKLDAALPQDVRHDITFELIQHRFT KPAKRVIEKNYPKTKLELDEEKRRYKWGRYGIGKYIYQKDEEHALREALESYIDTFFP NAKIEYFT*" /label="splB CDS" gene 1342965..1343993 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /label="splB gene" downshifts 1343963 /Source="Nicolas_upshifts" /id="D775" /incds=0 /nref=5 /ntot=113 /MaxReadThrough="0.352" /MaxDrop="3.95383" /score="15.9223136" /energy="-13.2" /TU="NA" /idTUdmin="U1136" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1344008..1344688) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase / amidohydrolase" /protein_id="NP_389277.2" /db_xref="EnsemblGenomes-Gn:BSU13940" /db_xref="EnsemblGenomes-Tr:CAB13267" /db_xref="GOA:Q796K9" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12252" /db_xref="UniProtKB/Swiss-Prot:Q796K9" /translation="MIILKQMYVHDGRKFEALTIRNYTETDIERLISLQEECFPPPFP QELLWSEDQLASHIKTFPEGALCALINGRIIGSMTALIVQFEPDSPDHTWAQATDNGS IKNHEPHGNTLYVVDISVSPHYRKLGIGKWLMNTMYELTVDKRLERLLGGGRIPLYYK YAHEISAVQYVEDVMEGRKNDPVLSFLLRCGRSPIRVVSNYLEDKESLNYGVLMEWKN VFYKKASC*" /label="ykwB CDS" gene complement(1344008..1344688) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /label="ykwB gene" promotor_-10 complement(1344698..1344717) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1344721) /Source="Nicolas_upshifts" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1344732..1344739) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1344773..1344780 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-35" promotor_-10 1344794..1344812 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-10" upshifts 1344800 /Source="Nicolas_upshifts" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="upshifts" CDS 1344823..1346790 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9721285, 11722727, 12603740, 15317802, 23038252, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9721285, 11722727, 12603740, 15317802, 23038252, 27899502; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_389278.2" /db_xref="EnsemblGenomes-Gn:BSU13950" /db_xref="EnsemblGenomes-Tr:CAB13268" /db_xref="GOA:P54576" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG11533" /db_xref="UniProtKB/Swiss-Prot:P54576" /translation="MFKKLHMKIAVFVSIMLIITVVLLMLSSYLTLKPMITEDGKNTT QNVTQSLEQNIELQLKSYAISLSRLANGELTHTFVTKPSKEASRLFHDDIKQIKDNDD YVAMAYIGTAKKEMFTYPKADFAEDYDPTSRPWYKLAAETPDQVVWTEPYKDVVTGDM IVTASKAILDRQKVIGVASYDLKLSAIQSMVNKQKVPYKGFAFLADASGNLLAHPSNQ GKNISKDQTLQTIASEKKGIQDVNGKMVVYQTIGETGWKVGTQFDTDQLMWISDKMNR ANLWISLIALIITIILSYFLAKTITGPIQQLIVKTKAVSAGDLTVRAESKSKDEVGIL TRDFNLMVENMKEMVEQVRLSSGKVSDTSEQLTAVAAETNETSGQIAKAIEEVAAGAS EQASEVETINEKSESLSTKIRQIAEEAGGIKERSKSSEDASYKGLDALGQLLMKSNEA NMETKKVETMLLDLENQTKNIEEVVTAISNISDQTNLLALNASIEAARAGESGRGFAV VADEVRKLAEQSALSTKHISETVKLIQLETKEASHAMVEASRMNDEQNSAIHETGEVL NTITAEMQSLVQGIDHIYAEIQRMSEEQLAISEAIQSISAISQESAAAAEEVNASTDE QLVTLDKVKHSTETLKHASQELMNTIAKFTL*" /label="mcpC CDS" gene 1344823..1346790 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /label="mcpC gene" misc_feature complement(1345263..1345278) /Source="Nicolas_upshift_promotors" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1345275) /Source="Nicolas_upshifts" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1346761 /Source="Nicolas_upshifts" /id="D776" /incds=0 /nref=134 /ntot=209 /MaxReadThrough="3.05506" /MaxDrop="5.75836" /score="24.6367658" /energy="-12.1" /TU="U1141" /idTUdmin="U1141" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1346834..1346836 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1346852..1346871 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1346862 /Source="Nicolas_upshifts" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1346904) /Source="Nicolas_upshifts" /id="D777" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="2.29647" /MaxDrop="4.49503" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=946 /isTUend="FALSE" /label="downshifts" CDS 1346928..1347794 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /EC_number="1.1.1.60" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20941576, 24390483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20941576, 24390483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacid dehydrogenase (acts on 3-hydroxypropionate with NADP)" /protein_id="NP_389279.1" /db_xref="EnsemblGenomes-Gn:BSU13960" /db_xref="EnsemblGenomes-Tr:CAB13269" /db_xref="GOA:O34948" /db_xref="InterPro:IPR002204" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13328" /db_xref="UniProtKB/Swiss-Prot:O34948" /translation="MKKTIGFIGLGVMGKSMASHILNDGHPVLVYTRTKEKAESILQK GAIWKDTVKDLSKEADVIITMVGYPSDVEEVYFGSNGIIENAKEGAYLIDMTTSKPSL AKKIAEAAKEKALFALDAPVSGGDIGAQNGTLAIMVGGEKEAFEACMPIFSLMGENIQ YQGPAGSGQHTKMCNQIAIAAGMIGVAEAMAYAQKSGLEPENVLKSITTGAAGSWSLS NLAPRMLQGNFEPGFYVKHFIKDMGIALEEAELMGEEMPGLSLAKSLYDKLAAQGEEN SGTQSIYKLWVK*" /label="ohaC CDS" gene 1346928..1347794 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /label="ohaC gene" downshifts 1347774 /Source="Nicolas_upshifts" /id="D778" /incds=0 /nref=239 /ntot=266 /MaxReadThrough="2.14032" /MaxDrop="8.18847" /score="41.1703019" /energy="-14.5" /TU="NA" /idTUdmin="U1143" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1347833..1348606) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389280.2" /db_xref="EnsemblGenomes-Gn:BSU13970" /db_xref="EnsemblGenomes-Tr:CAB13270" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR014258" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13329" /db_xref="UniProtKB/Swiss-Prot:O31398" /translation="MKKAFILSAAAAVGLFTFGGVQQASAKELSCQPVVTVKTGNTVQ NMSLNDAVKKLHINTNIKTLNAANEKEMKQLLQKHAKQSNVKVQDVQKTETAKPAQKT TEKAAADQNTASKAPATAEKTNTTTSAPSSVSAYEKKVVELTNAERQKQGLKPLQIDE TLSKSARAKSQDMKDKNYFDHQSPTYGSPFDMMKSFGISYKTAGENIAKGQKTPEEVV KAWMNSEGHRKNILNPNFTHIGVGYVESGSIWTQQFIGK*" /label="ykwD CDS" gene complement(1347833..1348606) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /label="ykwD gene" downshifts complement(1347850) /Source="Nicolas_upshifts" /id="D779" /incds=0 /nref=31 /ntot=168 /MaxReadThrough="1.32532" /MaxDrop="5.28625" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1348638..1348657) /Source="Nicolas_upshift_promotors" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1348648) /Source="Nicolas_upshifts" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1348881..1348900 /Source="Nicolas_upshift_promotors" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1348894 /Source="Nicolas_upshifts" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1348896..1348999 /Source="Nicolas_S_feature" /locus_tag="new_1467701_1467804" /HighExp="T4.0H, T3.30H, T3.0H, Etha, T5.0H, T2.30H, LoTm, B60, T2.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S507" CDS 1348943..1351057 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12896990, 23199363" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12896990, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding enzyme for formation of rod-shaped peptidoglycan cell wall" /protein_id="NP_389281.2" /db_xref="EnsemblGenomes-Gn:BSU13980" /db_xref="EnsemblGenomes-Tr:CAB13271" /db_xref="GOA:Q796K8" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13286" /db_xref="UniProtKB/Swiss-Prot:Q796K8" /translation="MTEIGREPKKKSKGNRAIRMNLFFLAVFVLFTALIFKLGVVQIV EGEQHEEDAEKSNAKTAYYPAPRGKMYDRNQKVAVDNQSVPEIVYVSTSSTKTEDKIK TAKRLASFIHIDTEFLKERDLRDYWIAAHPKKAAALLKESESNLKGDQAYKLQIERVP DQELKAIQQDDEEMETAAIYTRFSSGNAYEPQIVKAMNPNKSNSNGKNGALLDEKKNS SQRPKNDLTYDEISIVSEHLEELPGIDIVNDWTRKYPYDKTLYSVFGGVTTPDQGLLS DRKDFYLTRGYANNDRVGKSYLEYQYEEYLNSHKEKVEYVEDNKGNVVSQKTIDKGSR GYDLQLSFDMELQAKVEKIIEEEVRNSRARGNYMLDRAFAVMMDPNNGDILSMAGKKI DLKTNKIEDYAIGAFTTQYEMGSAVKGATVLAGYQDGIPHYKYYIDAPMLLGTNLIKK SYTNMGTINELTALQKSSNVYMFNVAMHIAGVTYKPHGSLPADQNDLLKMRNYYSQFG LGVKTGIDLPQESAGMQTTPKTVGGLILDLAIGQYDTYTPLQMAQYISVIANGGYRVQ PRIVTSIHKPGKKDQLGKAIEHRKPKVLNKINNSESDLKQVQTGMKLVTSSGTAKNTF TEDVSGKTGTAETFYYGTNRNWWGKKTYNLTFVGYYPSKKPKVAFSVVVPSVDDDDKI NKIIAKRAIHAYAELEKKHSKK*" /label="pbpH CDS" gene 1348943..1351057 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /label="pbpH gene" promotor_-10 complement(1350236..1350254) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1350248) /Source="Nicolas_upshifts" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1350270..1350275) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1351038 /Source="Nicolas_upshifts" /id="D780" /incds=0 /nref=139 /ntot=246 /MaxReadThrough="3.36066" /MaxDrop="5.01597" /score="-1.2500858" /energy="-12" /TU="U1145" /idTUdmin="U1145" /TUdmin="-1862" /isTUend="FALSE" /label="downshifts" promotor_-35 1351130..1351138 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1351150..1351168 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1351162 /Source="Nicolas_upshifts" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="upshifts" CDS 1351221..1353041 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation-specific ATP-dependent protein histidine kinase" /protein_id="NP_389282.1" /db_xref="EnsemblGenomes-Gn:BSU13990" /db_xref="EnsemblGenomes-Tr:CAB13272" /db_xref="GOA:P16497" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013655" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:2VLG" /db_xref="SubtiList:BG10204" /db_xref="UniProtKB/Swiss-Prot:P16497" /translation="MEQDTQHVKPLQTKTDIHAVLASNGRIIYISANSKLHLGYLQGE MIGSFLKTFLHEEDQFLVESYFYNEHHLMPCTFRFIKKDHTIVWVEAAVEIVTTRAER TEREIILKMKVLEEETGHQSLNCEKHEIEPASPESTTYITDDYERLVENLPSPLCISV KGKIVYVNSAMLSMLGAKSKDAIIGKSSYEFIEEEYHDIVKNRIIRMQKGMEVGMIEQ TWKRLDGTPVHLEVKASPTVYKNQQAELLLLIDISSRKKFQTILQKSRERYQLLIQNS IDTIAVIHNGKWVFMNESGISLFEAATYEDLIGKNIYDQLHPCDHEDVKERIQNIAEQ KTESEIVKQSWFTFQNRVIYTEMVCIPTTFFGEAAVQVILRDISERKQTEELMLKSEK LSIAGQLAAGIAHEIRNPLTAIKGFLQLMKPTMEGNEHYFDIVFSELSRIELILSELL MLAKPQQNAVKEYLNLKKLIGEVSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQ VFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKE KGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPKK*" /label="kinA CDS" gene 1351221..1353041 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /label="kinA gene" CDS complement(1353052..1354233) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /EC_number="2.6.1.83" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 14523133, 14627808, 19948795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 14523133, 14627808, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-L,L-diaminopimelate aminotransferase" /protein_id="NP_389283.2" /db_xref="EnsemblGenomes-Gn:BSU14000" /db_xref="EnsemblGenomes-Tr:CAB13273" /db_xref="GOA:P16524" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10205" /db_xref="UniProtKB/Swiss-Prot:P16524" /translation="MEHLLNPKAREIEISGIRKFSNLVAQHEDVISLTIGQPDFFTPH HVKAAAKKAIDENVTSYTPNAGYLELRQAVQLYMKKKADFNYDAESEIIITTGASQAI DAAFRTILSPGDEVIMPGPIYPGYEPIINLCGAKPVIVDTTSHGFKLTARLIEDALTP NTKCVVLPYPSNPTGVTLSEEELKSIAALLKGRNVFVLSDEIYSELTYDRPHYSIATY LRDQTIVINGLSKSHSMTGWRIGFLFAPKDIAKHILKVHQYNVSCASSISQKAALEAV TNGFDDALIMREQYKKRLDYVYDRLVSMGLDVVKPSGAFYIFPSIKSFGMTSFDFSMA LLEDAGVALVPGSSFSTYGEGYVRLSFACSMDTLREGLDRLELFVLKKREAMQTINNG V*" /label="dapX CDS" gene complement(1353052..1354233) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /label="dapX gene" downshifts complement(1353086) /Source="Nicolas_upshifts" /id="D781" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="1.89632" /MaxDrop="6.70715" /score="-6.17975559" /energy="-4.7" /TU="NA" /idTUdmin="U1148" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1354261..1354280) /Source="Nicolas_upshift_promotors" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1354277) /Source="Nicolas_upshifts" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1354309..1354327) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1354321) /Source="Nicolas_upshifts" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1354323..1354391) /Source="Nicolas_S_feature" /locus_tag="new_1473128_1473196_c" /HighExp="M9-stat, Lbtran, Lbstat, T3.30H, T3.0H, T2.30H, M0t90, T4.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S508" promotor_-35 complement(1354342..1354347) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1354385..1354404) /Source="Nicolas_upshift_promotors" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1354391) /Source="Nicolas_upshifts" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1354435..1354596) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097722.1" /db_xref="EnsemblGenomes-Gn:BSU14009" /db_xref="EnsemblGenomes-Tr:CAX52613" /db_xref="UniProtKB/Swiss-Prot:C0H406" /translation="MGTLVIFKENEMTVLEDISEETYLNMKKESADLQEEHPPYLIWH EDLHFDYGY*" /label="ykzT CDS" gene complement(1354435..1354596) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /label="ykzT gene" promotor_-10 complement(1354619..1354638) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1354632) /Source="Nicolas_upshifts" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1354652..1354659) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1354733..1354740 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1354752 /Source="Nicolas_upshifts" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1354753..1354771 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1354800..1355711 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11553614, 12864845, 14731274, 14993307, 26844549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11553614, 12864845, 14731274, 14993307, 26844549; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling protein and response regulator for CheAactivity in response to attractants (chemotaxis)" /protein_id="NP_389284.1" /db_xref="EnsemblGenomes-Gn:BSU14010" /db_xref="EnsemblGenomes-Tr:CAB13274" /db_xref="GOA:P37599" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024181" /db_xref="InterPro:IPR036061" /db_xref="SubtiList:BG10823" /db_xref="UniProtKB/Swiss-Prot:P37599" /translation="MSLQQYEILLDSGTNELEIVKFGVGENAFGINVMKVREIIQPVE VTSVPHSHQHVEGMIKLRGEILPVISLFSFFGVEPEGSKDEKYIVTEFNKRKIVFHVG SVSQIHRVSWEAIEKPTSLNQGMERHLTGIIKLEDLMIFLPDYEKIIYDIESDSGVDT YNMHTEGFDERRTDKKLIIVEDSPLLMRLLQDELKEAGYNNIASFENGKEAYEYIMNL AENETDLSKQIDMIITDIEMPKMDGHRLTKLLKENPKSSDVPVMIFSSLITDDLRHRG EVVGADEQISKPEISDLIKKVDTYVIE*" /label="cheV CDS" gene 1354800..1355711 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /label="cheV gene" downshifts complement(1354805) /Source="Nicolas_upshifts" /id="D782" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="1.14523" /MaxDrop="3.62759" /score="-8.29055697" /energy="-7.7" /TU="NA" /idTUdmin="U1154" /TUdmin=968 /isTUend="FALSE" /label="downshifts" promotor_-35 1355254..1355262 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1355276..1355293 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1355279 /Source="Nicolas_upshifts" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1355696 /Source="Nicolas_upshifts" /id="D783" /incds=0 /nref=188 /ntot=251 /MaxReadThrough="4.61331" /MaxDrop="6.23797" /score="15.4598573" /energy="-13.1" /TU="U1152" /idTUdmin="U1153" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1355755..1356219) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of transcription factor ComK function via modulation of mRNA stability" /protein_id="NP_389285.1" /db_xref="EnsemblGenomes-Gn:BSU14020" /db_xref="EnsemblGenomes-Tr:CAB13275" /db_xref="InterPro:IPR025552" /db_xref="SubtiList:BG11202" /db_xref="UniProtKB/Swiss-Prot:P42430" /translation="MDDHAYTKDLQPTVENLSKAVYTVNRHAKTAPNPKYLYLLKKRA LQKLVKEGKGKKIGLHFSKNPRFSQQQSDVLISIGDYYFHMPPTKEDFEHLPHLGTLN QSYRNPKAQMSLTKAKHLLQEYVGMKEKPLVPNRQQPAYHKPVFKKLGESYF*" /label="kre CDS" gene complement(1355755..1356219) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /label="kre gene" downshifts complement(1355773) /Source="Nicolas_upshifts" /id="D784" /incds=0 /nref=212 /ntot=260 /MaxReadThrough="2.67186" /MaxDrop="6.66359" /score="16.1985615" /energy="-13.1" /TU="NA" /idTUdmin="U1154" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1356249..1356268) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1356259) /Source="Nicolas_upshifts" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1356283..1356290) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1356345..1357637) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389286.2" /db_xref="EnsemblGenomes-Gn:BSU14030" /db_xref="EnsemblGenomes-Tr:CAB13276" /db_xref="GOA:O31695" /db_xref="InterPro:IPR004751" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13287" /db_xref="UniProtKB/Swiss-Prot:O31695" /translation="MDIFKNRNFVRLFFAALASQMGTTVGNMAFAFFLLDRFSSQPSY TTLAELMYSLPTIFVFLIVGVVADRFDRKKVAENCDWIRAGLTVVLFFTLFTGNIPLV FCILFIRSAVTKFFFPAENSLVQAILPKEHYAKAAGLNQMLFSIFMVFGVGIGAFMYN TIGIEGAIILDFVSFIISGLLIRSCRIPKEARQPNGAFSWRKTSVKDSINDFREGILY ILKNKLLASLIFGFFIFGFVNGGFAVLPMFTMKYGLAPDRYEWHTSVFTIALGFGLLA GSVIGTLISKKVKPHFLMSIPIFIAGLLIFVLGYTNILWVYYAAAFALGMCIGPINIA IGGWMPKIVHPKLMGRVSGMQDPFMMFAQSLTLGLVALLFPKFVSNIDYLYYGMGVII LLVFIFYFIALPKYSAQAVEVNVQEAFQEQPKKKARSV*" /label="ykuC CDS" gene complement(1356345..1357637) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /label="ykuC gene" downshifts complement(1356367) /Source="Nicolas_upshifts" /id="D785" /incds=0 /nref=37 /ntot=206 /MaxReadThrough="4.24449" /MaxDrop="4.31411" /score="3.5676583" /energy="-14.2" /TU="U1155" /idTUdmin="U1156" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1357661..1357680) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-10" upshifts complement(1357665) /Source="Nicolas_upshifts" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="upshifts" promotor_-35 complement(1357696..1357700) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-35" CDS complement(1357713..1358207) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11011148, 16287140, 23832002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16287140, 23832002; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="murein L,D-transpeptidase" /protein_id="NP_389287.1" /db_xref="EnsemblGenomes-Gn:BSU14040" /db_xref="EnsemblGenomes-Tr:CAB13277" /db_xref="GOA:O34816" /db_xref="InterPro:IPR005490" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="PDB:1Y7M" /db_xref="PDB:2MTZ" /db_xref="PDB:3ZQD" /db_xref="PDB:4A1I" /db_xref="PDB:4A1J" /db_xref="PDB:4A1K" /db_xref="PDB:4A52" /db_xref="SubtiList:BG13288" /db_xref="UniProtKB/Swiss-Prot:O34816" /translation="MLTYQVKQGDTLNSIAADFRISTAALLQANPSLQAGLTAGQSIV IPGLPDPYTIPYHIAVSIGAKTLTLSLNNRVMKTYPIAVGKILTQTPTGEFYIINRQR NPGGPFGAYWLSLSKQHYGIHGTNNPASIGKAVSKGCIRMHNKDVIELASIVPNGTRV TINR*" /label="ltdD CDS" gene complement(1357713..1358207) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /label="ltdD gene" promotor_-10 complement(1358223..1358242) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1358239) /Source="Nicolas_upshifts" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1358256..1358265) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1358264..1359124) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22767609, 24140208" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22767609, 24140208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported metallophosphoesterase (Mn2+ and Zn2+)" /protein_id="NP_389288.2" /db_xref="EnsemblGenomes-Gn:BSU14050" /db_xref="EnsemblGenomes-Tr:CAB13278" /db_xref="GOA:O34870" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR019546" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13289" /db_xref="UniProtKB/Swiss-Prot:O34870" /translation="MKKMSRRQFLKGMFGALAAGALTAGGGYGYARYLEPHMIETTEH TIKSSLIPHGFDGFKIVQFSDAHLSDYFTLEDLKTVILTINESKPDLIVFTGDIIDNP DTYQHHQAVIPLLRKLNAPFGKLCIYGNHDHGGYGTAVYKSLMTAGGFTVYRNGYQTL SLADGSKIEIASLDDLMLGNPDYEGTLSRLSDRLFSILLVHEPDAALKTTDYPVNLQL SGHTHGGQIQLPFYGPIITPPYGKVYTEGMYQTGSTHIYVNRGLGMTRLPLRFLAKPE ITVFTLKSTN*" /label="ppeE CDS" gene complement(1358264..1359124) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /label="ppeE gene" misc_feature complement(1359145..1359164) /Source="Nicolas_upshift_promotors" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1359158) /Source="Nicolas_upshifts" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="upshifts" promotor_-35 1359195..1359202 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-35" promotor_-10 1359218..1359237 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-10" upshifts 1359231 /Source="Nicolas_upshifts" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="upshifts" CDS 1359267..1360031 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /EC_number="1.3.1.34" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2,4-dienoyl-CoA reductase" /protein_id="NP_389289.1" /db_xref="EnsemblGenomes-Gn:BSU14060" /db_xref="EnsemblGenomes-Tr:CAB13279" /db_xref="GOA:O34717" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13290" /db_xref="UniProtKB/Swiss-Prot:O34717" /translation="MEKKAVIITGGSSGMGKAMAKKQAELGWHVMVTGRNHEALEETK KEIQTFEGQVACFQMDVRSDSAASDMIKEAVKAFGRLDALINNAAGNFICPAEKLTPN GWKAVIEIVLNGTFFCSQAAARHWIDQKQQGVILNMAATYAWGAGAGVVHSAAAKAGV LSLTRTLAVEWGSKYGIRTNAIAPGPIERTGGAEKLFESEKAMARTMNSVPLGRLGTP EEIAALAAFLLSDEASYINGDCITMDGGQWLNPYPF*" /label="fadH CDS" gene 1359267..1360031 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /label="fadH gene" S_feature 1360032..1360180 /Source="Nicolas_S_feature" /locus_tag="new_1478837_1478985" /HighExp="T0.30H, T1.0H, B60, Sw, BC, LoTm, M9-stat, S8, S7, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S509" misc_feature 1360161..1360179 /Source="Nicolas_upshift_promotors" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1360182..1360331 /Source="Nicolas_S_feature" /locus_tag="new_1478987_1479136" /HighExp="T0.30H, M40t90, T1.0H, B60, BC, Sw, LPh, LoTm, M9-stat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0, 0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S510" upshifts 1360182 /Source="Nicolas_upshifts" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1360229) /Source="Nicolas_upshifts" /id="D786" /incds=0 /nref=3 /ntot=49 /MaxReadThrough="1.82681" /MaxDrop="3.39884" /score="-0.170855674" /energy="-4.8" /TU="NA" /idTUdmin="U1157" /TUdmin="-2542" /isTUend="FALSE" /label="downshifts" CDS 1360332..1362062 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall-binding protein" /protein_id="YP_003097723.1" /db_xref="EnsemblGenomes-Gn:BSU14071" /db_xref="EnsemblGenomes-Tr:CAX52614" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="UniProtKB/Swiss-Prot:O34320" /translation="MDEMVLLTQEWLNETYKGKSGYNSIEENGKTGWKTMYALTRALQ LELGITQTSDSFGPTTLRKLKELGPISTSTNSKKNIVKIIQGALYCKGYGPGGLTGTF GQGTKEAIAEMQLHMGLSKTDGVVTPKVFKALLNMDSYILLNGASEKVRSIQQWLNNK YYNRENFYFMPCDGLYSRDTQKSLVYAIQYEEGLSDSIANGNFGPTTQRLIPVLRIGE TDEKNSFIHLFQAALIFNGYNVPFDGVYSESVRSKVKAFQSFAKLQQSGTADFQTWAS LLVSTGDPNRKGVACDSITQITSDRAESLKRAGYKIVGRYLTNAPGSTLNKKIQPGEL ETILKSGLNVFPIYQTYGGATNYFNKEQGKKDAFAAYKAAKEYGFKNNTVIYFAVDYD AYGNDLNNNIIPHFEGINEIMNGFLGSTYKIGIYAPRNVCTIVSKKGLAFASFVSGMS TGFSGNLGYPLPYNWAFDQISTITVGNGSGMIEIDNDICSGLDNGVNTINIVPSENKK FFDQIDVLYETAEKYAQMQSDLNNGVKKTQLANELVAQYLRKDDYKGWKWVPTAGQID PIYREWAVKR*" /label="ykuG CDS" gene 1360332..1362062 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /label="ykuG gene" CDS 1362128..1362646 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097724.1" /db_xref="EnsemblGenomes-Gn:BSU14072" /db_xref="EnsemblGenomes-Tr:CAX52615" /db_xref="UniProtKB/Swiss-Prot:C0H408" /translation="MATYNAIIYSGGYSQTLRDFAGWTGDLLTTIQDMKLHAQEFNSP YDAAMKIIGNMYQFSLDDLFSDVDAINLANKTSVGANAQPLNIAIRDYYSNNDCMNRF TQFVNNRFDGSLDKIFSEAEYYLNTNLDPVVVPIRLAFKRAFDVEDYSEEIGKITAQA FRDVIEKKMISE*" /label="ykzU CDS" gene 1362128..1362646 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /label="ykzU gene" downshifts 1362644 /Source="Nicolas_upshifts" /id="D787" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.57306" /MaxDrop="3.8585" /score="8.20824413" /energy="-13" /TU="U1158,U1159" /idTUdmin="U1158" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" promotor_-35 1362689..1362694 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1362707..1362726 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1362710 /Source="Nicolas_upshifts" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="upshifts" CDS 1362742..1363290 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389291.1" /db_xref="EnsemblGenomes-Gn:BSU14080" /db_xref="EnsemblGenomes-Tr:CAB13281" /db_xref="GOA:O31696" /db_xref="SubtiList:BG13292" /db_xref="UniProtKB/Swiss-Prot:O31696" /translation="MKKLLKKLVVLFLSSLVIIFNVWYFIICAFSPEYYQNTNLTSNE IIRFEKLYHIDFPDETKFIKAREYLAGPGGDTSAVLYVSLPTKRVEKVLSDYTYMKIN YTDNVGSMYGVDVSKSVAGLTTLTFGTYDKKGTFYNMKHDDDWMYKGTDWNLYFWTAA SYNAVIFVFVLVIVKQMNKILN*" /label="ykuH CDS" gene 1362742..1363290 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /label="ykuH gene" S_feature 1363291..1363442 /Source="Nicolas_S_feature" /locus_tag="new_1482096_1482247" /HighExp="HiOs, LPhT, Salt, T0.0H, HiTm, T-0.40H, Fru, T-1.10H, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S511" CDS 1363443..1364666 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19244251, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative cyclic-di-GMP receptor (no phosphodiesterase activity)" /protein_id="NP_389292.1" /db_xref="EnsemblGenomes-Gn:BSU14090" /db_xref="EnsemblGenomes-Tr:CAB13282" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR018842" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035919" /db_xref="PDB:2BAS" /db_xref="PDB:2W27" /db_xref="SubtiList:BG13293" /db_xref="UniProtKB/Swiss-Prot:O35014" /translation="MLDPLDILTNIDDVLPYYQAIFSAEEQKVVGYEVLGRILADSEI QSLGPFFLDAGIPEEYKLEVDNRIIRQALDRFLEADSDLLIFMNQDANLLMLDHGESF LELLKEYEAKGIELHRFVLEITEHNFEGDIEQLYHMLAYYRTYGIKIAVDNIGKESSN LDRIALLSPDLLKIDLQALKVSQPSPSYEHVLYSISLLARKIGAALLYEDIEANFQLQ YAWRNGGRYFQGYYLVSPSETFLERDVLKQRLKTEFHQFITHEKKKLETVYEHSEQFY KRVHQAVTSLRKNNLSSDDDFIKKLAEELTDCSFRIYMCDEEGDQLTGNVFKQDGEWI YQPEYAEKNWSWRPYFLENIMRMRNLRKGFFSDLYSDLETGEMIRTFSYPMDDQMYLF IDLPYSYLYEQDGLI*" /label="ykuI CDS" gene 1363443..1364666 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /label="ykuI gene" promotor_-10 complement(1364629..1364647) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1364639) /Source="Nicolas_upshifts" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1364645 /Source="Nicolas_upshifts" /id="D788" /incds=0 /nref=132 /ntot=229 /MaxReadThrough="3.48305" /MaxDrop="4.61382" /score="32.6727777" /energy="-7.5" /TU="U1159" /idTUdmin="U1160" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 complement(1364662..1364667) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1364715..1364722 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1364734..1364835 /Source="Nicolas_S_feature" /locus_tag="new_1483539_1483640" /HighExp="B36, B60, nit, Pyr, BI, HiOs, T-0.40H, S5, GM 15, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S512" upshifts 1364734 /Source="Nicolas_upshifts" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="upshifts" promotor_-10 1364737..1364756 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" misc_RNA 1364752..1364835 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /product="regulatory RNA controlling iron-dependent metabolism" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629, 24576839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629, 24576839; Product type n: RNA" /function="12: Regulatory functions" /label="fsrA RNA" gene 1364752..1364835 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /label="fsrA gene" downshifts 1364792 /Source="Nicolas_upshifts" /id="D789" /incds=0 /nref=61 /ntot=192 /MaxReadThrough="6.41968" /MaxDrop="7.54463" /score="16.5898261" /energy="-8.8" /TU="U1159,U1162" /idTUdmin="U1159" /TUdmin="-74" /isTUend="FALSE" /label="downshifts" promotor_-35 1364846..1364851 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1364866..1365150 /Source="Nicolas_S_feature" /locus_tag="new_1483671_1483955" /HighExp="S4, H2O2, S5, Paraq, B60, nit, GM 10, B36, GM 25, GM 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147452" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S513" upshifts 1364866 /Source="Nicolas_upshifts" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="upshifts" promotor_-10 1364868..1364886 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-10" promotor_-35 1365127..1365133 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" promotor_-10 1365147..1365158 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" S_feature 1365152..1365239 /Source="Nicolas_S_feature" /locus_tag="new_1483957_1484044" /HighExp="S5, S4, H2O2, B60, Paraq, nit, B36, GM 10, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigEF, SigA" /TUshortPSig="0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S514" upshifts 1365152 /Source="Nicolas_upshifts" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="upshifts" misc_feature 1365228..1365247 /Source="Nicolas_upshift_promotors" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1365241 /Source="Nicolas_upshifts" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1365312..1365551 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16387657, 18436958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-specific modification enzyme subunit" /protein_id="NP_389293.1" /db_xref="EnsemblGenomes-Gn:BSU14100" /db_xref="EnsemblGenomes-Tr:CAB13283" /db_xref="InterPro:IPR014904" /db_xref="PDB:2FFG" /db_xref="SubtiList:BG13294" /db_xref="UniProtKB/Swiss-Prot:O34588" /translation="MSQLMGIITRLQSLQETAEAANEPMQRYFEVNGEKICSVKYFEK NQTFELTVFQKGEKPNTYPFDNIDMVSIEIFELLQ*" /label="ykuJ CDS" gene 1365312..1365551 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /label="ykuJ gene" S_feature 1365552..1365660 /Source="Nicolas_S_feature" /locus_tag="new_1484357_1484465" /HighExp="H2O2, LoTm, G135, Paraq, G180, LBGexp, G150, Oxctl, dia0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S515" CDS 1365661..1366179 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16165328, 24464998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding enzyme component" /protein_id="NP_389294.1" /db_xref="EnsemblGenomes-Gn:BSU14110" /db_xref="EnsemblGenomes-Tr:CAB13284" /db_xref="InterPro:IPR007405" /db_xref="SubtiList:BG13295" /db_xref="UniProtKB/Swiss-Prot:O34776" /translation="MADSFLFYNLSEAQMTFQDVMERLKAFVQKDPRSSYVLSIGTDS QVYRDYTKFITALHLHRTGKGAWGCLKNHTVDRPIHSLREKISLETAYSQETAAHILD GHLMDITDLLLPFTGEGADLTFEVHLDIGKKGLTKDLIQEMTGRITSMGIEAKIKPDS YTAFSYANRFTK*" /label="ykuK CDS" gene 1365661..1366179 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /label="ykuK gene" promotor_-35 1366216..1366223 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1366237..1366256 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1366251 /Source="Nicolas_upshifts" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1366313..1366510 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18840696, 24534728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18840696, 24534728; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of AbrB repressor" /protein_id="NP_389295.1" /db_xref="EnsemblGenomes-Gn:BSU14120" /db_xref="EnsemblGenomes-Tr:CAB13285" /db_xref="GOA:O31697" /db_xref="InterPro:IPR025446" /db_xref="PDB:2LZF" /db_xref="SubtiList:BG13334" /db_xref="UniProtKB/Swiss-Prot:O31697" /translation="MRMSLIGERFTEEEQKLLLNILINHEYAIELLSSEINDIETGTK NVDGTTYKKLVTLYDRFRFEN*" /label="abbA CDS" gene 1366313..1366510 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /label="abbA gene" downshifts 1366506 /Source="Nicolas_upshifts" /id="D790" /incds=0 /nref=114 /ntot=265 /MaxReadThrough="5.72556" /MaxDrop="4.65809" /score="2.45376472" /energy="-6.8" /TU="U1165,U1166" /idTUdmin="U1162" /TUdmin=12 /isTUend="TRUE" /label="downshifts" S_feature 1366551..1366647 /Source="Nicolas_S_feature" /locus_tag="new_1485356_1485452" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, M0t90, T1.0H, T5.0H, T2.30H, T1.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.23094000000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S516" CDS 1366648..1367091 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11985717; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA-binding protein" /protein_id="NP_389296.1" /db_xref="EnsemblGenomes-Gn:BSU14130" /db_xref="EnsemblGenomes-Tr:CAB13286" /db_xref="PDB:1YAV" /db_xref="SubtiList:BG13296" /db_xref="UniProtKB/Swiss-Prot:O31698" /translation="MISLQSDQLLEATVGQFMIEADKVAHVQVGNNLEHALLVLTKTG YTAIPVLDPSYRLHGLIGTNMIMNSIFGLERIEFEKLDQITVEEVMLTDIPRLHINDP IMKGFGMVINNGFVCVENDEQVFEGIFTRRVVLKELNKHIRSLNK*" /label="ykuL CDS" gene 1366648..1367091 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /label="ykuL gene" S_feature 1367092..1367199 /Source="Nicolas_S_feature" /locus_tag="new_1485897_1486004" /HighExp="M0t90, M40t90, M9-stat, T1.0H, T3.30H, T3.0H, T4.0H, S2, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S517" promotor_-35 1367167..1367172 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1367187..1367206 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1367201 /Source="Nicolas_upshifts" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1367240..1368121 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14636591, 16352834, 16395550, 23139400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636591, 16352834, 16395550, 23139400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of citB and citZ" /protein_id="NP_389297.1" /db_xref="EnsemblGenomes-Gn:BSU14140" /db_xref="EnsemblGenomes-Tr:CAB13287" /db_xref="GOA:O34827" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13297" /db_xref="UniProtKB/Swiss-Prot:O34827" /translation="MQLQELHMLVVLAEELNMRKAAERLFVSQPALSQRLQTIEKAWG TKIFLRSQKGLTVTPAGEKIIQFANDVTLEQERIRENIDELEGEIHGTLKLAVASIIG QHWLPKVLKTYVEKYPNAKISLITGWSSEMLKSLYEDQVHIGIIRGNPEWKGRKDYLM TDHLYLVDTEISCIEDIAHTERPFIQFKSDSTYFQEIQHWWHQKFKTSPKQTILVDQI ETCKQMALHGIGYAILPSVTLQNEDKVNKMPLLDMKGHPIGRDTWLLGYEPAFELKQV QAFVQVIKDMLDQENPF*" /label="ccpC CDS" gene 1367240..1368121 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /label="ccpC gene" downshifts 1368100 /Source="Nicolas_upshifts" /id="D791" /incds=0 /nref=168 /ntot=242 /MaxReadThrough="1.76921" /MaxDrop="5.2505" /score="37.6563581" /energy="-8.3" /TU="NA" /idTUdmin="U1165" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1368156..1368163 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1368178..1368197 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1368183 /Source="Nicolas_upshifts" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="upshifts" CDS 1368233..1368709 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin (acts in lipid desaturation)" /protein_id="NP_389298.1" /db_xref="EnsemblGenomes-Gn:BSU14150" /db_xref="EnsemblGenomes-Tr:CAB13288" /db_xref="GOA:O34737" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13298" /db_xref="UniProtKB/Swiss-Prot:O34737" /translation="MAKALITYASMSGNTEDIAFIIKDTLQEYELDIDCVEINDMDAS CLTSYDYVLIGTYTWGDGDLPYEAEDFFEEVKQIQLNGLKTACFGSGDYSYPKFCEAV NLFNVMLQEAGAAVYQETLKIELAPETDEDVESCRAFARGFLAWADYMNKEKIHVS*" /label="fldN CDS" gene 1368233..1368709 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /label="fldN gene" CDS 1368699..1369592 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12354229, 24214949" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389299.1" /db_xref="EnsemblGenomes-Gn:BSU14160" /db_xref="EnsemblGenomes-Tr:CAB13289" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG13299" /db_xref="UniProtKB/Swiss-Prot:O34879" /translation="MFHKGATAVTASAFSGYFVAVQREGIFHYSLEQGWRKLFRLKSK IHCISYIGPYLFGVGEKGTVIRSADEGKTWTMSSFPTNATVWAITGRNNGFVCAHGKH CIYVSDDFGVSWRVAKPFAEFHNPPVIRSLCLHGGNLFIGTQIHEYFGGIWAYDIKRD TVQVVKKEKNRMTASMLVFNENWLVAAMGSVKGKHGAVTVRNLLNGEEFTIQSSMIRN EESFLDLSEDDGIIYVTTTQDENGFSRIYQVDLEARSLKWFDTIKGHGWRVANQKENF FCAGLYECKFVQPYEVSAMIH*" /label="ykuO CDS" gene 1368699..1369592 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /label="ykuO gene" CDS 1369608..1370063 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin" /protein_id="NP_389300.2" /db_xref="EnsemblGenomes-Gn:BSU14170" /db_xref="EnsemblGenomes-Tr:CAB13290" /db_xref="GOA:O34589" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001226" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13300" /db_xref="UniProtKB/Swiss-Prot:O34589" /translation="MAKILLVYATMSGNTEAMADLIEKGLQEALAEVDRFEAMDIDDA QLFTDYDHVIMGTYTWGDGDLPDEFLDLVEDMEEIDFSGKTCAVFGSGDTAYEFFCGA VDTLEAKIKERGGDIVLPSVKIENNPEGEEEEELINFGRQFAKKSGCAV*" /label="fldP CDS" gene 1369608..1370063 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /label="fldP gene" promotor_-10 complement(1369879..1369898) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1369892) /Source="Nicolas_upshifts" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1369912..1369920) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1370057 /Source="Nicolas_upshifts" /id="D792" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="6.48855" /MaxDrop="3.75748" /score="20.7202933" /energy="-9" /TU="U1168" /idTUdmin="U1165" /TUdmin=1957 /isTUend="FALSE" /label="downshifts" promotor_-35 1370102..1370109 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1370123..1370142 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1370124 /Source="Nicolas_upshifts" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="upshifts" CDS 1370168..1370878 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /EC_number="2.3.1.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5411754, 10368155, 11910040, 12682299, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5411754, 10368155, 11910040, 12682299, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetrahydrodipicolinate N-acetyltransferase" /protein_id="NP_389301.2" /db_xref="EnsemblGenomes-Gn:BSU14180" /db_xref="EnsemblGenomes-Tr:CAB13291" /db_xref="GOA:O34981" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR013710" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR019873" /db_xref="SubtiList:BG13301" /db_xref="UniProtKB/Swiss-Prot:O34981" /translation="MKMMDANEIISFIQNSTKSTPVKVYVKGELEGINFGESAKAFIN GNTGVVFGEWSEIQTAIEENQSKIEDYVVENDRRNSAIPMLDLKNIKARIEPGAIIRD QVEIGDNAVIMMGASINIGSVIGEGTMIDMNVVLGGRATVGKNCHIGAGSVLAGVIEP PSAKPVVIEDDVVIGANAVVLEGVTVGKGAVVAAGAIVVNDVEPYTVVAGTPAKKIKD IDEKTKGKTEIKQELRQL*" /label="dapH CDS" gene 1370168..1370878 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /label="dapH gene" downshifts complement(1370177) /Source="Nicolas_upshifts" /id="D793" /incds=0 /nref=60 /ntot=165 /MaxReadThrough="1.03272" /MaxDrop="4.75802" /score="28.9046709" /energy="-15" /TU="NA" /idTUdmin="U1171" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1370287..1370291) /Source="Nicolas_upshift_promotors" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1370287) /Source="Nicolas_upshifts" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1370948..1372072 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /EC_number="3.5.1.47" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14627808, 17093042, 24261876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14627808, 17093042, 24261876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-diaminopimelate deacetylase" /protein_id="NP_389302.1" /db_xref="EnsemblGenomes-Gn:BSU14190" /db_xref="EnsemblGenomes-Tr:CAB13292" /db_xref="GOA:O34916" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR023905" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13302" /db_xref="UniProtKB/Swiss-Prot:O34916" /translation="MKIEELIAIRRDLHRIPELGFQEFKTQQYLLNVLEQYPQDRIEI EKWRTGLFVKVNGTAPEKMLAYRADIDALSIEEQTGLPFASEHHGNMHACGHDLHMTI ALGIIDHFVHHPVKHDLLFLFQPAEEGPGGAEPMLESDVLKKWQPDFITALHIAPELP VGTIATKSGLLFANTSELVIDLEGKGGHAAYPHLAEDMVVAASTLVTQLQTIISRNTD PLDSAVITVGTITGGSAQNIIAETAHLEGTIRTLSEESMKQVKERIEDVVKGIEIGFR CKGKVTYPSVYHQVYNTSGLTEEFMSFVAEHQLATVIEAKEAMTGEDFGYMLKKYPGF MFWLGADSEHGLHHAKLNPDENAIETAVHVMTGYFSVYAN*" /label="dapI CDS" gene 1370948..1372072 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /label="dapI gene" promotor_-35 1372084..1372090 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1372104..1372115 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1372106 /Source="Nicolas_upshifts" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1372110..1372124) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1372134..1372138) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1372134..1372379 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389303.1" /db_xref="EnsemblGenomes-Gn:BSU14200" /db_xref="EnsemblGenomes-Tr:CAB13293" /db_xref="InterPro:IPR005370" /db_xref="SubtiList:BG13303" /db_xref="UniProtKB/Swiss-Prot:O34783" /translation="MAKKIGIEQSLSDVEAALKEKGYDVVMMKSPADAQGCDCCVVTG LDNNVQGIADTVTQAPVITASGMTAEEICSEVESRIQ*" /label="ykuS CDS" gene 1372134..1372379 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /label="ykuS gene" upshifts complement(1372135) /Source="Nicolas_upshifts" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1372367 /Source="Nicolas_upshifts" /id="D794" /incds=0 /nref=238 /ntot=269 /MaxReadThrough="3.49553" /MaxDrop="5.88829" /score="3.56597112" /energy="-9.9" /TU="U1172" /idTUdmin="U1168" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1372412..1373362 /Source="Nicolas_S_feature" /locus_tag="new_1491217_1492167" /HighExp="S4, S5, S6, S3, S7, S8, LoTm, BT, B36, G135" /AntisenseName="ykuT" /AntisenseCor="-0.479447808227356" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S518" CDS complement(1372416..1373219) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /function="16.6: Maintain" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12626684, 17665170, 18310427, 19252899, 21150093" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12626684, 17665170, 18310427, 19252899, 21150093; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small-conductance mechanosensitive channel" /protein_id="NP_389304.2" /db_xref="EnsemblGenomes-Gn:BSU14210" /db_xref="EnsemblGenomes-Tr:CAB13294" /db_xref="GOA:O34897" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13304" /db_xref="UniProtKB/Swiss-Prot:O34897" /translation="MDFIKQYDWAGLITNAGVLLIKLAIMILLYFIVRSLGMKIIKHL FAKFEEQNSLSIGRAHTLRSLTLNIFAYTLIFIFFVMVLDLFHYDPSALLAGAGIVGL AVGFGAQGLVSDIVTGFFILLEKQLDVGDYITVSTFDGIVEQVGLRTTQIRSFDGTLH YIPNRNITNVSNHSRGTMQALVDIKVPAERNIDEMIHILQQVCDETAAALPQIKEGPN VIGIQELGTSEIVIRVIAKTENMEQWRVERVLRKEIKNAFDRAFPKETE*" /label="mscT CDS" gene complement(1372416..1373219) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /label="mscT gene" downshifts complement(1372428) /Source="Nicolas_upshifts" /id="D795" /incds=0 /nref=16 /ntot=131 /MaxReadThrough="1.65551" /MaxDrop="4.4361" /score="29.0050313" /energy="-9.9" /TU="NA" /idTUdmin="U1174" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1373270..1373289) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1373279) /Source="Nicolas_upshifts" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1373303..1373310) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1373335..1373342 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-35" promotor_-10 1373357..1373376 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-10" S_feature 1373364..1373455 /Source="Nicolas_S_feature" /locus_tag="new_1492169_1492260" /HighExp="LPhT, Salt, Etha, M9-stat, M0t90, T4.0H, T5.0H, S4, Heat, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S519" upshifts 1373364 /Source="Nicolas_upshifts" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="upshifts" CDS 1373456..1373998 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /EC_number="1.11.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:22938038, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22938038, 27683249; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biofilm-specific peroxidase; 2-cys peroxiredoxin" /protein_id="NP_389305.1" /db_xref="EnsemblGenomes-Gn:BSU14220" /db_xref="EnsemblGenomes-Tr:CAB13295" /db_xref="GOA:O34564" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13305" /db_xref="UniProtKB/Swiss-Prot:O34564" /translation="MAERMVGKQAPRFEMEAVLASKEFGKVSLEENMKNDKWTVLFFY PMDFTFVCPTEITAMSDRYDEFEDLDAEVIGVSTDTIHTHLAWINTDRKENGLGQLKY PLAADTNHEVSREYGVLIEEEGVALRGLFIINPEGELQYQTVFHNNIGRDVDETLRVL QALQTGGLCPANWKPGQKTL*" /label="ahpA CDS" gene 1373456..1373998 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /label="ahpA gene" CDS 1374070..1374516 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /EC_number="1.8.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15937154, 16132829, 16418167" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 16132829, 16418167; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_389306.2" /db_xref="EnsemblGenomes-Gn:BSU14230" /db_xref="EnsemblGenomes-Tr:CAB13296" /db_xref="GOA:O31699" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:2B5X" /db_xref="PDB:2B5Y" /db_xref="SubtiList:BG13306" /db_xref="UniProtKB/Swiss-Prot:O31699" /translation="MKLRQPMPELTGEKAWLNGEVTREQLIGEKPTLIHFWSISCHLC KEAMPQVNEFRDKYQDQLNVVAVHMPRSEDDLDPGKIKETAAEHDITQPIFVDSDHAL TDAFENEYVPAYYVFDKTGQLRHFQAGGSGMKMLEKRVNRVLAETE*" /label="ykuV CDS" gene 1374070..1374516 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /label="ykuV gene" downshifts 1374524 /Source="Nicolas_upshifts" /id="D796" /incds=0 /nref=58 /ntot=211 /MaxReadThrough="3.11112" /MaxDrop="4.73023" /score="10.8864177" /energy="-5.4" /TU="U1175" /idTUdmin="U1172" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1374909..1374916 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1374929 /Source="Nicolas_upshifts" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1374931..1374950 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1374982..1375557 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 27902860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 27902860; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of comK" /protein_id="NP_389307.1" /db_xref="EnsemblGenomes-Gn:BSU14240" /db_xref="EnsemblGenomes-Tr:CAB13297" /db_xref="GOA:O34857" /db_xref="SubtiList:BG13307" /db_xref="UniProtKB/Swiss-Prot:O34857" /translation="MFNEREALRLRLEQLNEAEVKVIREYQIERDKIYAKLRELDRNG SPSEIKKDFRSEKKPDSLPVLAELAAQEIRSYQPQSQQQSVQPQLQSISSLPAGIPDG TTRRRRGTARPGSKAAKLREAAIKTLKRHNAAIKSSELQKEIEKESGLEIPNMTTFMQ SLIKMYPEVKKPYRGQYILEGEIESAESANE*" /label="rok CDS" gene 1374982..1375557 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /label="rok gene" downshifts 1375535 /Source="Nicolas_upshifts" /id="D797" /incds=0 /nref=246 /ntot=258 /MaxReadThrough="1.77207" /MaxDrop="6.35121" /score="17.7584572" /energy="-9" /TU="NA" /idTUdmin="U1176" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1375598..1376563) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /experiment="publication(s) with functional evidences, PMID:8990290, 15383836, 15743949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 15383836, 15743949; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein cse15" /protein_id="NP_389308.1" /db_xref="EnsemblGenomes-Gn:BSU14250" /db_xref="EnsemblGenomes-Tr:CAB13298" /db_xref="GOA:O31700" /db_xref="SubtiList:BG12251" /db_xref="UniProtKB/Swiss-Prot:O31700" /translation="MKRSGPFFHDVSQENLYLKSELSRCHKLISELEASYFHQKNNKL LKENTDMKEKLQQLSAELTHMSTKEKHASHTSQTLHQIRAELLDKIVVLQELLSAETY KRRAEIEEKHKLHIAKVKIEEENKNLHKRISELQASIEQEQNALLQAKQQAELIKAEN GRLKEQMVEKEYQLKHIKIEVDHMKDRIIETKERLLDIEKTKEKLFHETIISYKRQLD ESDAWIASHFADIDGGTKQKEKTEEEAPAAYAQPNHVETILEDVTKQIHVLQKQLAHA QSSDQAKSHTIEELKNRAAEEKPYQKWVYKLNLEKENKPSQKKPQ*" /label="sppO CDS" gene complement(1375598..1376563) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /label="sppO gene" downshifts complement(1375611) /Source="Nicolas_upshifts" /id="D798" /incds=0 /nref=47 /ntot=67 /MaxReadThrough="2.24884" /MaxDrop="5.5936" /score="3.60334458" /energy="-7.2" /TU="NA" /idTUdmin="U1178" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1375907..1375908 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1375926..1375945 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1375932..1376656 /Source="Nicolas_S_feature" /locus_tag="new_1494737_1495461" /HighExp="dia15, Diami, dia5, H2O2, G135, G150, G180, LBGexp, Paraq, Lbexp" /AntisenseName="yknT" /AntisenseCor="-0.36512493899072102" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S520" upshifts 1375932 /Source="Nicolas_upshifts" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1376584..1376602) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1376605) /Source="Nicolas_upshifts" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1376617..1376622) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1376643..1376649 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1376659 /Source="Nicolas_upshifts" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1376663..1376682 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1376700..1377299 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /EC_number="2.7.7.77" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10978347; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein A" /protein_id="NP_389309.1" /db_xref="EnsemblGenomes-Gn:BSU14260" /db_xref="EnsemblGenomes-Tr:CAB13299" /db_xref="GOA:O31701" /db_xref="InterPro:IPR013482" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12621" /db_xref="UniProtKB/Swiss-Prot:O31701" /translation="MKHVNVLLAGGASRRFGEPKAFVKWKGRMLYECAKEALGEQTVI ISRPEFIDRFQENGENEVYQDAEPFQGMGPLAGIYTAFKKTDGDLYTVLSCDTPLIQR RTMLELKRLMIAGADAVVPISDGQVQPLIAIYHKRIMPVLYDQLSEKRLRISDLLGRI SVCYVQAENIGANPAEFININTRDDFSCLEEKSNSLKRD*" /label="mobA CDS" gene 1376700..1377299 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /label="mobA gene" CDS 1377350..1378369 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /EC_number="2.7.7.80" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17223713; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin biosynthesis adenylyltransferase" /protein_id="NP_389310.1" /db_xref="EnsemblGenomes-Gn:BSU14270" /db_xref="EnsemblGenomes-Tr:CAB13300" /db_xref="GOA:O31702" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG12624" /db_xref="UniProtKB/Swiss-Prot:O31702" /translation="MEERYSRQIRFKQIGEEGQKRLADSHVLIVGAGALGTAGAEGLS RAGVGTITIIDRDYVEWSNLQRQQLYTESDAKLRMPKAMAAKEHLSAINSEIHIEAYV TEGTAETLEPLIEKADVVIDATDNFETRMLINDLAQKTKTPWVYGACVSSQGMFMTVI PGETPCLSCLFEQIPVGGATCDTAGIIPPAVHIVSAYQQAEALKLLTGQKEAIQRGFV TFDVWNNSHMKINVNHVRREECPSCGANAVYPYLQDWNTPKAAVLCGRDTVQVRSESL KRIPKQELIKRLKTIGKVEANAFLLHIFYEDFRIVIFNDGRALVHGTNDVKEANSVLA RVIGL*" /label="moeB CDS" gene 1377350..1378369 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /label="moeB gene" CDS 1378387..1379679 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /EC_number="2.10.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11428898, 12006571, 18959753, 21206014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdate to molybdopterin ligation enzyme" /protein_id="NP_389311.1" /db_xref="EnsemblGenomes-Gn:BSU14280" /db_xref="EnsemblGenomes-Tr:CAB13301" /db_xref="GOA:O31703" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR005110" /db_xref="InterPro:IPR005111" /db_xref="InterPro:IPR036135" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036688" /db_xref="SubtiList:BG12623" /db_xref="UniProtKB/Swiss-Prot:O31703" /translation="MLEKRTPIPVDEAVRRVCHFQKQGETEWVALEDSLHRFLAEDIT ADHHVPAFDRSPYDGFAVRACDTAEASRENPVRFEVIDHIGAGAVSEKELGPFQAVRI MTGAQIPEGADAVVMIELTQAFEENGKSFMSLKRRFQTGDNISKTGEDAQKGSVLLTK GTRVTPGVTALLATFGYASVPVVRKPVVGIIATGTELLNVSDPLEPGKIRNSNASMVY AQAIEAGATPLYLGKISDELDKSFAAVKEAMKKVDFLITTGGVSVGDFDFLPAIYEKL GADVLFNKVAMRPGSVTTVAHANDMLLFGLSGNPSACYVGFELFVKPIIQTWLLNETP HSICAEAVLTKDFPKPNPFTRFVRALVHHQEGKLLATPVGLDKSSSVTSLADANAFII LPGGTRGYESGRTVQVLLIREENGSEWPWSVLSRSSKL*" /label="moeA CDS" gene 1378387..1379679 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /label="moeA gene" CDS 1379640..1380161 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9219527, 12682065, 12719427; Product type c: carrier" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein B" /protein_id="NP_389312.1" /db_xref="EnsemblGenomes-Gn:BSU14290" /db_xref="EnsemblGenomes-Tr:CAB13302" /db_xref="GOA:O31704" /db_xref="InterPro:IPR004435" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12622" /db_xref="UniProtKB/Swiss-Prot:O31704" /translation="MALVRPFPIVQVVGFQNSGKTTFIERILEKASEQGVHLGCLKHH GHGGEPQTLTEGKDTDRYKAAGADVTAVEGAGVLQLTARRNWDLARLIELYQFLETDC LLIEGFKKAPYPKVVILSEKEDLEALQAVNIIAIIYRKKEHMTEHQGLPVFHADDPVA VDFVLSQLKGESA*" /label="mobB CDS" gene 1379640..1380161 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /label="mobB gene" CDS 1380161..1380634 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /EC_number="2.8.1.12" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 18092812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (large subunit)" /protein_id="NP_389313.1" /db_xref="EnsemblGenomes-Gn:BSU14300" /db_xref="EnsemblGenomes-Tr:CAB13303" /db_xref="GOA:O31705" /db_xref="InterPro:IPR003448" /db_xref="InterPro:IPR036563" /db_xref="SubtiList:BG12620" /db_xref="UniProtKB/Swiss-Prot:O31705" /translation="MERFEITKTPINTENIIKKVEKREAGAITTFIGTVREWTNGKRT VRLEYEAYEPMAVQMLAQIGAEIEEKWEGASAAITHRIGVLDIGEAAVVIAVSSPHRK AAYEANEYAIERIKQIVPIWKKEIWEDGEQWIGDQLETTAYPNGKPDLSEGEQHD*" /label="moaE CDS" gene 1380161..1380634 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /label="moaE gene" CDS 1380627..1380860 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 17223713, 19946146; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (small subunit)" /protein_id="NP_389314.1" /db_xref="EnsemblGenomes-Gn:BSU14310" /db_xref="EnsemblGenomes-Tr:CAB13304" /db_xref="GOA:O31706" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010034" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="SubtiList:BG12619" /db_xref="UniProtKB/Swiss-Prot:O31706" /translation="MIKILLFAGLAEQAGTQAIEIDMEQATTDEIKASLKEQYGLESI DTAMIAVNESYVKENTSVSSGDTVAIIPPVSGG*" /label="moaD CDS" gene 1380627..1380860 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /label="moaD gene" downshifts 1380839 /Source="Nicolas_upshifts" /id="D799" /incds=0 /nref=87 /ntot=240 /MaxReadThrough="1.14308" /MaxDrop="5.73073" /score="32.0123217" /energy="-16.9" /TU="NA" /idTUdmin="U1177" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 1380905..1380910 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-35" promotor_-10 1380927..1380945 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-10" upshifts 1380935 /Source="Nicolas_upshifts" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="upshifts" S_feature 1380947..1381033 /Source="Nicolas_S_feature" /locus_tag="new_1499752_1499838" /HighExp="S4, S5, S3, T5.0H, T4.0H, Pyr, S6, T3.30H, M9-stat, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S521" promotor_-35 1381023..1381026 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1381035 /Source="Nicolas_upshifts" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1381041..1381060 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1381084..1382841 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389315.1" /db_xref="EnsemblGenomes-Gn:BSU14320" /db_xref="EnsemblGenomes-Tr:CAB13305" /db_xref="GOA:O31707" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13241" /db_xref="UniProtKB/Swiss-Prot:O31707" /translation="METFKRLKMYYWPYRKVFMWSLLAMLLMTAITVVYPIILQITID EIVLGRQYQLAAWVSLGFIAVMVLKGMATFFHQYLGDMFGIKSVYRLRNGLYEKLQRL SFSYYDNAKTGDLMSRLTADVEGLRFFLSYGLAELIRFGLLVAISLSVMFYYSVPLTL VTIAVLPFLAVAVYRFDKRVHPAFRGIRKSFAKLNTKVQENISGINTVKSLSREDFQI STFNKANAEYRAQYLQTSSIWSAYFPLMEFIGNTCIVALLSYGGYLVMQNQLNPGELV AFFSLVNYMMWPIMNLGFVINMFSQAKASGERLLDILEKEEDITDHPHALHKQKLTGD VHFKNVSLAYGKEQTNALCNVSFEANSGKVIGLLGPTGSGKSSVTQLLTRFYSPVGGM ITIDHKPITDYSLKTLRSNIGVVLQESFLFSSTIRSNISYGRPDASMEDVIEAAKRAQ AHNFIMELPDGYDTMLGERGMGLSGGQKQRIAIARAICLNPSILILDDATSAVDMQTE HSIQLALKEVMKNRTTFIVAHRISSLKHADEILVFNKGRIRERGTHHELLEKGGYYKK IYDLQYRDVKMINEPHEVG*" /label="yknU CDS" gene 1381084..1382841 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /label="yknU gene" CDS 1382853..1384667 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389316.1" /db_xref="EnsemblGenomes-Gn:BSU14330" /db_xref="EnsemblGenomes-Tr:CAB13306" /db_xref="GOA:O31708" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13242" /db_xref="UniProtKB/Swiss-Prot:O31708" /translation="MKQAKKQGVLERFYYSSDEIIEKPFNWAQMWRLLSYVKPYRKTI LPLSFLTVLIGTAVKLVIPILIGVYVLDQAITGRNSELLIQLIFIISGLYVLNYAANV LRIRWMNQLGQHVIYDLRQHLFTHVQRLSHRFFDQRSAGSILVRIMNDINSLQELFTS GVINLLTDLLLLAGVIIILFTLSPELTIAIMVTLPIMFFISTSLRKKIRRSWQTVRLK QSKLNSHLNESIQGIRVTQAFTQEEENMAYFDGVNQENYESWREATRKNAMFRPLVEM TNAIGTAVLIWYGATLIMNETITIGVFVSFAFYLGMFWEPISRLGQVYNQLLMGMASS ERIFEFLDEQPNVKEKPNAIHNEKINGEISFEEVEFSYDEKRKALHAVSFSIPAGSTL ALVGHTGSGKTTIANLISRFYDAAGGTIKIDGIPIKDLSLASLRSQISIVLQDTFIFS GTIMENIRFGRPNASDEEVMKASQAVGADEFISDLAEGYATEVEERGSVLSAGQRQLI SFARALLADPAIIILDEATASIDTETEVKIQQALKTLLKGRTAVMIAHRLSTIRDADR IIVLDHGRKIEEGNHDQLLAKGGIYAGLVKAQYSTAIE*" /label="yknV CDS" gene 1382853..1384667 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /label="yknV gene" promotor_-10 complement(1383290..1383309) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1383300) /Source="Nicolas_upshifts" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1383324..1383331) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1384718..1384727 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1384739..1384754 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1384743 /Source="Nicolas_upshifts" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="upshifts" CDS 1384777..1385472 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of permease exporting the starvation-induced killing protein" /protein_id="NP_389317.1" /db_xref="EnsemblGenomes-Gn:BSU14340" /db_xref="EnsemblGenomes-Tr:CAB13307" /db_xref="GOA:O31709" /db_xref="InterPro:IPR006977" /db_xref="SubtiList:BG13243" /db_xref="UniProtKB/Swiss-Prot:O31709" /translation="METNVEKNSGTATEKPSLFGVITSPSVQFERIRERPAVWGPLLI VAAIIIVGAVLQSLGTDYSELLKSQDTQGLSAEQMETVATITKFGGMAGAIIGGIAAL FIAPLIYWLCVKVSGGVTTYKKMLSLSLFVSLISSLGLLVNGIVAFTTDVNPLYSTTS LAGIIPSDGALASVLNTFEIFSIWSFVLLAIGLHKTGGISKKAGWISAIILFGILVVF SLFSGLINSVAGA*" /label="skiW CDS" gene 1384777..1385472 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /label="skiW gene" CDS 1385477..1386610 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11544226, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544226, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein" /protein_id="NP_389318.1" /db_xref="EnsemblGenomes-Gn:BSU14350" /db_xref="EnsemblGenomes-Tr:CAB13308" /db_xref="GOA:O31710" /db_xref="InterPro:IPR006143" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG13244" /db_xref="UniProtKB/Swiss-Prot:O31710" /translation="MKKVWIGIGIAVIVALFVGINIYRSAAPTSGSAGKEVQTGSVEE NEISSTVMVPGTLKFSNEQYVFYEADKGTLEDIKVKEGDKVKKGTALVTYTNEQLSLE KEQNQLTSESNRLQIDQIQEKLKALDSKERELEKQVGKKEAEKQIESERTELQMQKKT AEIELKQTELQRQSLANRVSDLEVKSEIEGTVISVNQEAASKKSDIQEPVIHIGNPKD LVVSGKLSEYDTLKVKKGQKVTLTSDVIQGKTWKGTVSAVGLVPDQQESAAAQGTEQA VQYPLQVKIKGNLPEGKPGFKFIMNIETDKRKANTLPSKAVKKEDDQYYVYTVKDGKA KRVDVKIGEVTDDLTEIKEGLTQDDQVILNPSDQVTDGMEVKS*" /label="skiX CDS" gene 1385477..1386610 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /label="skiX gene" CDS 1386611..1387303 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein (ATP-binding protein)" /protein_id="NP_389319.1" /db_xref="EnsemblGenomes-Gn:BSU14360" /db_xref="EnsemblGenomes-Tr:CAB13309" /db_xref="GOA:O31711" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13245" /db_xref="UniProtKB/Swiss-Prot:O31711" /translation="MIQLSNVRKSYQIGKETFDVLHSIDLDIHQGEYVSIMGPSGSGK STIMNIIGCLDRPTSGTYQLDGEDISSYKDKELAAVRNRSIGFVFQQFQLLPRLNAKK NVELPMIYSGIGKKERQERAERALEKVGLADRMLHMPNELSGGQKQRVAIARAIVNEP KLILADEPTGALDTKTSEAIMDQFTALNAEGTTIVLVTHEPEVADCTNRIVMVRDGNI VPASSGQRSVGE*" /label="skiY CDS" gene 1386611..1387303 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /label="skiY gene" CDS 1387300..1388493 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703, 22720735, 27243566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703, 22720735, 27243566; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease subunit exporting Sporulation-Delaying Protein" /protein_id="NP_389320.1" /db_xref="EnsemblGenomes-Gn:BSU14370" /db_xref="EnsemblGenomes-Tr:CAB13310" /db_xref="GOA:O31712" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR005085" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13246" /db_xref="UniProtKB/Swiss-Prot:O31712" /translation="MSLLENIRMALSSVLAHKMRSILTMLGIIIGVGSVIVVVAVGQG GEQMLKQSISGPGNTVELYYMPSDEELASNPNAAAESTFTENDIKGLKGIEGIKQVVA STSESMKARYHEEETDATVNGINDGYMNVNSLKIESGRTFTDNDFLAGNRVGIISQKM AKELFDKTSPLGEVVWINGQPVEIIGVLKKVTGLLSFDLSEMYVPFNMMKSSFGTSDF SNVSLQVESADDIKSAGKEAAQLVNDNHGTEDSYQVMNMEEIAAGIGKVTAIMTTIIG SIAGISLLVGGIGVMNIMLVSVTERTREIGIRKSLGATRGQILTQFLIESVVLTLIGG LVGIGIGYGGAALVSAIAGWPSLISWQVVCGGVLFSMLIGVIFGMLPANKAAKLDPIE ALRYE*" /label="skiZ CDS" gene 1387300..1388493 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /label="skiZ gene" downshifts 1388471 /Source="Nicolas_upshifts" /id="D800" /incds=0 /nref=79 /ntot=210 /MaxReadThrough="3.49546" /MaxDrop="4.46952" /score="36.2703425" /energy="-12.1" /TU="U1183" /idTUdmin="U1183" /TUdmin="-396" /isTUend="FALSE" /label="downshifts" promotor_-35 1388542..1388548 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1388562..1388573 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1388570 /Source="Nicolas_upshifts" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1388615..1388622 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-35" promotor_-10 1388637..1388656 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-10" S_feature 1388642..1388733 /Source="Nicolas_S_feature" /locus_tag="new_1507447_1507538" /HighExp="UNK1, LPh, HPh, Fru, G180, MG 5, C30, G135, MG t5, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigWXY" /TUshortPSig="0.967, 0.86, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S522" upshifts 1388642 /Source="Nicolas_upshifts" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="upshifts" promotor_-35 1388697..1388704 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1388718..1388737 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1388735 /Source="Nicolas_upshifts" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="upshifts" CDS 1388773..1389528 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563858; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (DeoR family)" /protein_id="NP_389321.1" /db_xref="EnsemblGenomes-Gn:BSU14380" /db_xref="EnsemblGenomes-Tr:CAB13311" /db_xref="GOA:O31713" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12589" /db_xref="UniProtKB/Swiss-Prot:O31713" /translation="MLTPERHQLIIDQIEKHDVVKIQELINLTNASESTIRRDLSTLE ERGFLKRVHGGAAKLSDIRLEPDMLEKSSKNLHDKLKIAEKAASLLEEGDCIYLDAGT TTLHMIDFMDKTKDIVVVTNGVMHIDALIRKEISFYLLGGYVKHRTGAIIGGASLVAM DQYRFDKSFLGTNGVHTEAGFTTPDPDEALLKQKAIKQAKHAYVLADPSKFGEISFSA FAGIGDATIITTDAEELTFDNYQEKTVVKVVKP*" /label="fruR CDS" gene 1388773..1389528 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /label="fruR gene" upshifts complement(1388921) /Source="Nicolas_upshifts" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1388923..1388925) /Source="Nicolas_upshift_promotors" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1389525..1390436 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /EC_number="2.7.1.56" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 168069, 14563858, 24328040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1-phosphate kinase" /protein_id="NP_389322.1" /db_xref="EnsemblGenomes-Gn:BSU14390" /db_xref="EnsemblGenomes-Tr:CAB13312" /db_xref="GOA:O31714" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR017583" /db_xref="InterPro:IPR022463" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12588" /db_xref="UniProtKB/Swiss-Prot:O31714" /translation="MIYTVTLNPSVDYIVHVEDFTVGGLNRSSYDTKYPGGKGINVSR LLKRHHVASKALGFVGGFTGEYIKTFLREENLETAFSEVKGDTRINVKLKTGDETEIN GQGPTISDEDFKAFLEQFQSLQEGDIVVLAGSIPSSLPHDTYEKIAEACKQQNARVVL DISGEALLKATEMKPFLMKPNHHELGEMFGTAITSVEEAVPYGKKLVEQGAEHVIVSM AGDGALLFTNEAVYFANVPKGKLVNSVGAGDSVVAGFLAGISKQLPLEEAFRLGVTSG SATAFSEELGTEEFVQQLLPEVKVTRL*" /label="fruK CDS" gene 1389525..1390436 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /label="fruK gene" CDS 1390451..1392358 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /EC_number="2.7.1.202" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:118007, 200418" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 118007, 200418; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIABC component" /protein_id="NP_389323.1" /db_xref="EnsemblGenomes-Gn:BSU14400" /db_xref="EnsemblGenomes-Tr:CAB13313" /db_xref="GOA:P71012" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003353" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004715" /db_xref="InterPro:IPR006327" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="PDB:2R4Q" /db_xref="SubtiList:BG11938" /db_xref="UniProtKB/Swiss-Prot:P71012" /translation="MKITELLTKHTIKLNIESKEKENVIDEMVTVLDKAGKLNDRQAY KEAILNRESQSSTGIGEGIAIPHAKTASVINPAIAFGRSKDGVDYESLDGQPAHLVFM IAATEGANNTHLEALSRLSTLLMREEIRKQLLEAESEDAIIDIINQHDKDDDEEEEEE EAAPAPAGKGKILAVTACPTGIAHTFMAADALKEKAKELGVEIKVETNGSSGIKHKLT AQEIEDAPAIIVAADKQVEMERFKGKRVLQVPVTAGIRRPQELIEKAMNQDAPIYQGS GGGSAASNDDEEAKGKSGSGIGNTFYKHLMSGVSNMLPFVVGGGILVAISFFWGIHSA DPNDPSYNTFAAALNFIGGDNALKLIVAVLAGFIAMSIADRPGFAPGMVGGFMATQAN AGFLGGLIAGFLAGYVVILLKKVFTFIPQSLDGLKPVLIYPLFGIFITGVLMQFVVNT PVAAFMNFLTNWLESLGTGNLVLMGIILGGMMAIDMGGPLNKAAFTFGIAMIDAGNYA PHAAIMAGGMVPPLGIALATTIFRNKFTQRDREAGITCYFMGAAFVTEGAIPFAAADP LRVIPAAVVGAAVAGGLTEFFRVTLPAPHGGVFVAFITNHPMLYLLSIVIGAVVMAII LGIVKKPVTEK*" /label="fruA CDS" gene 1390451..1392358 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /label="fruA gene" downshifts 1392343 /Source="Nicolas_upshifts" /id="D801" /incds=0 /nref=133 /ntot=228 /MaxReadThrough="3.99928" /MaxDrop="5.27169" /score="11.7516734" /energy="-11.4" /TU="U1185" /idTUdmin="U1186" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1392427..1392434 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1392445..1392464 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1392448 /Source="Nicolas_upshifts" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="upshifts" CDS 1392503..1393084 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11283286, 11807061, 12897006, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11283286, 11807061, 12897006, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_389324.1" /db_xref="EnsemblGenomes-Gn:BSU14410" /db_xref="EnsemblGenomes-Tr:CAB13314" /db_xref="GOA:P71013" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11977" /db_xref="UniProtKB/Swiss-Prot:P71013" /translation="MTEEKNTNTEKTAKKKTNTYLEWGKAIVIAVLLALLIRHFLFEP YLVEGSSMYPTLHDGERLFVNKTVNYIGELKRGDIVIINGETSKIHYVKRLIGKPGET VQMKDDTLYINGKKVAEPYLSKNKKEAEKLGVSLTGDFGPVKVPKGKYFVMGDNRLNS MDSRNGLGLIAEDRIVGTSKFVFFPFNEMRQTK*" /label="sipT CDS" gene 1392503..1393084 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /label="sipT gene" downshifts 1393069 /Source="Nicolas_upshifts" /id="D802" /incds=0 /nref=90 /ntot=226 /MaxReadThrough="3.7981" /MaxDrop="6.13957" /score="5.03270493" /energy="-9.8" /TU="U1188" /idTUdmin="U1188" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1393113 /Source="Nicolas_upshifts" /id="D803" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.6676" /MaxDrop="3.60225" /score="5.03270493" /energy="-9.8" /TU="NA" /idTUdmin="U1188" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1393118..1393387) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389325.1" /db_xref="EnsemblGenomes-Gn:BSU14420" /db_xref="EnsemblGenomes-Tr:CAB13315" /db_xref="GOA:O31715" /db_xref="SubtiList:BG13247" /db_xref="UniProtKB/Swiss-Prot:O31715" /translation="MRLLTLTEYCLLIFFTGFYLAVTGFTAKDIGLYIGIALIYIFSH IFSKRLLEKRGKENKQVHLFFSVLAIIGSVFITVLCIALVASFSK*" /label="ykoA CDS" gene complement(1393118..1393387) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /label="ykoA gene" downshifts complement(1393123) /Source="Nicolas_upshifts" /id="D804" /incds=0 /nref=38 /ntot=254 /MaxReadThrough="2.08491" /MaxDrop="5.70938" /score="11.210199" /energy="-9.8" /TU="U1189" /idTUdmin="U1189" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" S_feature complement(1393388..1393453) /Source="Nicolas_S_feature" /locus_tag="new_1512193_1512258_c" /HighExp="LoTm, Gly, Lbstat, Sw, Cold, C30, HPh, S0, T0.30H, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S523" misc_feature complement(1393434..1393453) /Source="Nicolas_upshift_promotors" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1393453) /Source="Nicolas_upshifts" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1393506..1393513 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1393524..1393543 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1393528 /Source="Nicolas_upshifts" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="upshifts" CDS 1393568..1395190 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10816464, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_389326.1" /db_xref="EnsemblGenomes-Gn:BSU14430" /db_xref="EnsemblGenomes-Tr:CAB13316" /db_xref="GOA:O31716" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG13270" /db_xref="UniProtKB/Swiss-Prot:O31716" /translation="MIAVNNVSLRFADRKLFEDVNIKFTPGNCYGLIGANGAGKSTFL KVLSGEIEPQTGDVHMSPGERLAVLKQNHFEYEEYEVLKVVIMGHKRLYEVMQEKDAI YMKPDFSDEDGIRAAELEGEFAELNGWEAESEAAILLKGLGISEDLHTKKMADLGGSE KVKVLLAQALFGKPDVLLLDEPTNHLDLQAIQWLEEFLINFENTVIVVSHDRHFLNKV CTHIADLDFNKIQIYVGNYDFWYESSQLALKLSQEANKKKEEQIKQLQEFVARFSANA SKSKQATSRKKLLEKITLDDIKPSSRRYPYVNFTPEREIGNDVLRVEGLTKTIDGVKV LDNVSFIMNREDKIAFTGRNELAVTTLFKIISGEMEADSGTFKWGVTTSQAYFPKDNS EYFEGSDLNLVDWLRQYSPHDQSESFLRGFLGRMLFSGEEVHKKANVLSGGEKVRCML SKAMLSGANILILDEPTNHLDLESITALNNGLISFKGAMLFTSHDHQFVQTIANRIIE ITPNGIVDKQMSYDEFLENADVQKKLTELYAE*" /label="ykpA CDS" gene 1393568..1395190 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /label="ykpA gene" downshifts 1395178 /Source="Nicolas_upshifts" /id="D805" /incds=0 /nref=45 /ntot=239 /MaxReadThrough="5.13671" /MaxDrop="3.6227" /score="17.6386925" /energy="-7.6" /TU="U1190" /idTUdmin="U1190" /TUdmin="-993" /isTUend="FALSE" /label="downshifts" CDS 1395247..1396158 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 15966718, 17229734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate reductase" /protein_id="NP_389327.1" /db_xref="EnsemblGenomes-Gn:BSU14440" /db_xref="EnsemblGenomes-Tr:CAB13317" /db_xref="GOA:O31717" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13271" /db_xref="UniProtKB/Swiss-Prot:O31717" /translation="MKFLVVGAGGVGGYIGGRLSEKGNDVTFLVRQKRAEQLKKTGLV IHSEKGNVSFQPELISAGETGQFDVVIIASKAYSLGQVIEDVKPFIHQESVIIPFLNG YRHYEQLFAAFSKEQVLGGLCFIESALDNKGEIHHTSASHRFVFGEWNGERTERIRAL EEAFSGVKAEVIISGHIEKDIWKKYLFIAAQAGITTLFQRPLGPILATEAGRHTAQTL IGEICTVLRKEGVPADPALEEESFRTMTSMSYHMKSSMLRDMENGQTTEGDHLHGFLI EKAKRLSLAAPVLETVYANLQMYEAEK*" /label="panE CDS" gene 1395247..1396158 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /label="panE gene" downshifts 1396163 /Source="Nicolas_upshifts" /id="D806" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="2.04919" /MaxDrop="4.55439" /score="11.4959806" /energy="-9.6" /TU="NA" /idTUdmin="U1190" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(1396192..1397424) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /EC_number="3.4.11.24" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9362117, 16088219, 22808738" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9362117, 16088219, 22808738; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase" /protein_id="NP_389328.1" /db_xref="EnsemblGenomes-Gn:BSU14450" /db_xref="EnsemblGenomes-Tr:CAB13318" /db_xref="GOA:P39762" /db_xref="InterPro:IPR000787" /db_xref="InterPro:IPR035097" /db_xref="SubtiList:BG10986" /db_xref="UniProtKB/Swiss-Prot:P39762" /translation="MDSFSQKLNTYAQLAVEVGVNVQKGQYVVVNASTDVRDFVRLIV KHAYEKGAKNVTVNWQDDEVAKLKYELAPFEAFEEYPEWEAKGREELAKNGAAFISVV SSNPDLLKGIDSKRIAAFQKAAGKALHTYRQYIQSDKVSWTVVGAASAGWAHKVFPGK SEEEAIHLLWEEIFKATRVNEDNPVQAWINHDQNLHEKVDHLNERHYAALHYQAEGTD LTIKLPRKHVWAGAGSVNESGHEFMANMPTEEVFTLPQKDGVDGVVSSTKPLSYGGNI IENFTLTFENGRIVDIKAEKGEDILKELVETDEGSHYLGEVALVPYDSPISQSNILFY NTLFDENASNHLAIGSAYAFNIEGGKQMSREELVKEGLNESITHVDFMIGSKDMNIDG ITADGKREPIFRNGNWAF*" /label="ampS CDS" gene complement(1396192..1397424) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /label="ampS gene" downshifts complement(1396203) /Source="Nicolas_upshifts" /id="D807" /incds=0 /nref=215 /ntot=254 /MaxReadThrough="1.34101" /MaxDrop="5.7635" /score="40.7811053" /energy="-9.6" /TU="NA" /idTUdmin="U1191" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1397442..1397461) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1397466) /Source="Nicolas_upshifts" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1397476..1397481) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1397534..1397668) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389329.1" /db_xref="EnsemblGenomes-Gn:BSU14460" /db_xref="EnsemblGenomes-Tr:CAB13319" /db_xref="InterPro:IPR035379" /db_xref="SubtiList:BG11812" /db_xref="UniProtKB/Swiss-Prot:Q45492" /translation="MLRDLGRRVAIAAILSGIILGGMSISLANMPHSPAGGTVKLNHP *" /label="ykpC CDS" gene complement(1397534..1397668) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /label="ykpC gene" downshifts complement(1397545) /Source="Nicolas_upshifts" /id="D808" /incds=0 /nref=51 /ntot=151 /MaxReadThrough="3.10365" /MaxDrop="5.04142" /score="-2.2377884" /energy="-9.1" /TU="U1192" /idTUdmin="U1193" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1397690..1397708) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1397701) /Source="Nicolas_upshifts" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1397703..1397768) /Source="Nicolas_S_feature" /locus_tag="new_1516508_1516573_c" /HighExp="HiTm, C30, Lbstat, MG-0.2, BC, G135, MG 15, MG 10, MG-0.1, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S524" promotor_-35 complement(1397724..1397729) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1397769..1398776) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16950129, 19643765, 19659933, 21091501, 21636651, 26091431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950129, 19643765, 19659933, 21091501, 21636651, 26091431; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_389330.1" /db_xref="EnsemblGenomes-Gn:BSU14470" /db_xref="EnsemblGenomes-Tr:CAB13320" /db_xref="GOA:P39763" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10987" /db_xref="UniProtKB/Swiss-Prot:P39763" /translation="MFQSTEIGIDLGTANILVYSKNKGIILNEPSVVAVDTTTKAVLA IGADAKNMIGKTPGKIVAVRPMKDGVIADYDMTTDLLKHIMKKAAKSIGMSFRKPNVV VCTPSGSTAVERRAISDAVKNCGAKNVHLIEEPVAAAIGADLPVDEPVANVVVDIGGG TTEVAIISFGGVVSCHSIRIGGDQLDEDIVSFVRKKYNLLIGERTAEQVKMEIGHALI EHIPEAMEIRGRDLVTGLPKTIMLQSNEIQDAMRESLLHILEAIRATLEDCPPELSGD IVDRGVILTGGGALLNGIKEWLTEEIVVPVHVAQNPLESVAIGTGRSLEVIDKLQKAI K*" /label="mreBH CDS" gene complement(1397769..1398776) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /label="mreBH gene" upshifts complement(1398822) /Source="Nicolas_upshifts" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1398823..1398831) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1398845..1398853) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1398963..1398972 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-35" upshifts 1398984 /Source="Nicolas_upshifts" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="upshifts" promotor_-10 1398985..1399000 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-10" S_feature 1398987..1399059 /Source="Nicolas_S_feature" /locus_tag="new_1517792_1517864" /HighExp="Lbexp, dia5, LBGexp, dia0, Lbtran, Mt0, Oxctl, Paraq, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S525" CDS 1399060..1399338 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16159768, 17720793, 19767430, 20817675, 20844865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159768, 17720793, 19767430, 20817675, 20844865; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389331.1" /db_xref="EnsemblGenomes-Gn:BSU14480" /db_xref="EnsemblGenomes-Tr:CAB13321" /db_xref="GOA:P39758" /db_xref="InterPro:IPR007159" /db_xref="PDB:2FY9" /db_xref="PDB:2RO3" /db_xref="SubtiList:BG10988" /db_xref="UniProtKB/Swiss-Prot:P39758" /translation="MKSIGVVRKVDELGRIVMPIELRRALDIAIKDSIEFFVDGDKII LKKYKPHGVCLMTGEITSENKEYGNGKITLSPEGAQLLLEEIQAALKE*" /label="abhA CDS" gene 1399060..1399338 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /label="abhA gene" downshifts 1399336 /Source="Nicolas_upshifts" /id="D809" /incds=0 /nref=61 /ntot=238 /MaxReadThrough="4.68201" /MaxDrop="5.62457" /score="7.91393519" /energy="-11" /TU="U1194" /idTUdmin="U1194" /TUdmin="-135" /isTUend="FALSE" /label="downshifts" S_feature complement(1399370..1400999) /Source="Nicolas_S_feature" /locus_tag="new_1518175_1519804_c" /HighExp="S6, S8, S5, LoTm, S4, S7, S3, C30, T5.0H, BT" /AntisenseName="kinC" /AntisenseCor="-0.76370141168998495" /AntisenseRegPval="-51.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S526" S_feature 1399381..1399485 /Source="Nicolas_S_feature" /locus_tag="new_1518186_1518290" /HighExp="Oxctl, Lbexp, LBGexp, H2O2, dia0, Paraq, G180, G150, G135, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S527" downshifts complement(1399393) /Source="Nicolas_upshifts" /id="D810" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.833919999999999" /MaxDrop="3.11258" /score="8.02057524" /energy="-11" /TU="NA" /idTUdmin="U1196" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1399467..1399474 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1399486..1399505 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1399487 /Source="Nicolas_upshifts" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="upshifts" CDS 1399528..1400814 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /EC_number="2.7.13.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-responsive histidine kinase regulating cannibalism and biofilm formation" /protein_id="NP_389332.1" /db_xref="EnsemblGenomes-Gn:BSU14490" /db_xref="EnsemblGenomes-Tr:CAB13322" /db_xref="GOA:P39764" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10989" /db_xref="UniProtKB/Swiss-Prot:P39764" /translation="MRKYQARIISIILAMIFIMFWDYLFYFIGKNPINWPVDIVYTAV TLVSVWMLAYYIDEKQQLVKKMKDNEWKYKQLSEEKNRIMDNLQEIVFQTNAKGEITY LNQAWASITGFSISECMGTMYNDYFIKEKHVADHINTQIQNKASSGMFTAKYVTKNGT IFWGEVHYKLYYDRDDQFTGSLGTMSDITERKEAEDELIEINERLARESQKLSITSEL AAGIAHEVRNPLTSVSGFLQIMKTQYPDRKDYFDIIFSEIKRIDLVLSELLLLAKPQA ITFKTHQLNEILKQVTTLLDTNAILSNIVIEKNFKETDGCMINGDENQLKQVFINIIK NGIEAMPKGGVVTISTAKTASHAVISVKDEGNGMPQEKLKQIGKPFYSTKEKGTGLGL PICLRILKEHDGELKIESEAGKGSVFQVVLPLKSDS*" /label="kinC CDS" gene 1399528..1400814 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /label="kinC gene" CDS 1400830..1401663 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /EC_number="2.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28537416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative gamma-glutamylcyclotransferase (bacillithiol degradation)" /protein_id="NP_389333.1" /db_xref="EnsemblGenomes-Gn:BSU14500" /db_xref="EnsemblGenomes-Tr:CAB13323" /db_xref="GOA:P39759" /db_xref="InterPro:IPR009288" /db_xref="InterPro:IPR013024" /db_xref="InterPro:IPR036568" /db_xref="PDB:2QIK" /db_xref="SubtiList:BG10990" /db_xref="UniProtKB/Swiss-Prot:P39759" /translation="MNSLLFVYGTLRKHEKNHHLLAQSACINEQARTKGSLFAAKEGP TVVFNDEDEGYIYGEVYEADELCIHKLDQFFQGYHKQTVFVETDVGIKIALIYFMNKD GCAGFTKISSGDWKEHQMISKSKNPIYYFAYGSCMDNARFQKAGVDHYFQDPVGRAVL KGYTTRFTLKREDGSRADMLEDGGTTEGVLYRIPYSALSYLYKREGVESLTYRPAFVD VEAGGRHYKDCLTFLVLQKEAEIAPPQHYQIEIERGAELYLSPEFTEKLKRHMNSLPK G*" /label="ykqA CDS" gene 1400830..1401663 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /label="ykqA gene" promotor_-10 complement(1400996..1401014) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1401011) /Source="Nicolas_upshifts" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1401030..1401035) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1401726..1402391 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 22720735, 23963175, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 22720735, 23963175, 28420751; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_389334.1" /db_xref="EnsemblGenomes-Gn:BSU14510" /db_xref="EnsemblGenomes-Tr:CAB13324" /db_xref="GOA:P39760" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG10991" /db_xref="UniProtKB/Swiss-Prot:P39760" /translation="MKKEFAVIGLGRFGGSICKALSEEGVEVMAMDIDEDKVNEYAKI ASHAVIGDSTDESVLKNLGLRNFDHVIVAIGENIQASILTTLILKELGVHTITVKAQN DYHEKVLSKIGADHIVHPERDMAKRIAHNIVSNNVLDYLELSEEHSLVEIVANSRLAG NTLLDLDIRAKYGINIVAIKRGKEVIVSPLATEVIHQEDILIVIGSVTDISRFEKRVL HTK*" /label="ktrC CDS" gene 1401726..1402391 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /label="ktrC gene" downshifts 1402375 /Source="Nicolas_upshifts" /id="D811" /incds=0 /nref=191 /ntot=256 /MaxReadThrough="3.15176" /MaxDrop="5.50828" /score="4.60161255" /energy="-8.2" /TU="U1195" /idTUdmin="U1195" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 1402482..1402488 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1402503..1402522) /Source="Nicolas_upshift_promotors" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1402503..1402522 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1402515 /Source="Nicolas_upshifts" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1402517) /Source="Nicolas_upshifts" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1402546..1404279 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 8550522, 17183219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 8550522, 17183219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine deaminase" /protein_id="NP_389335.2" /db_xref="EnsemblGenomes-Gn:BSU14520" /db_xref="EnsemblGenomes-Tr:CAB13325" /db_xref="GOA:P39761" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11044" /db_xref="UniProtKB/Swiss-Prot:P39761" /translation="MNKEALVNRLNASAKRQKADIVIKNGKIMDVYNQEWIYEDIAIT DGVIVGLGEYEGENIIDAEGQMIVPGFIDGHVHIESSMVTPIEFAKAVLPHGVTTVVT DPHEIANVSGEKGIEFMLEQARHTPLNIHFMLPSSVPAASFERSGAILKAADLKPFYE EEEVLGLAEVMDYVSVQQAEKDMVQKLLDARVAGKRIDGHLAGLSTDLINIYRTAFVL NDHEVTSKEEALDRIRRGMYVMMREGSVAKNTLNVLPAVNEKNARRFFFCTDDKHVDD LLSEGSVNHQVKMAIQAGLNPFLAYQLGSLNAAECYGLDTKGAIAPGFDADLLFVSDL ENVTVTMTMVKGQTVAEDSKAVYQDHASTAAPDQALLDSVKLAAPLNKQDFHMPIDSE QQINVIQIIPNQLETRLVQVPAPVAREFEPDTELDLLKIAVVERHKGLKETGLGVVKG FGFKSGAIATTISHDSHNIIAVGTNDEDIAAAVNKLQEIGGGLTIIKNGEELHSVPLP IAGLLSDQSAEQVNQSLLTLHDKLSLIGFTGGFNPFLTLSFLALPVIPDIKMTTTGLF DVKSFQHISLQ*" /label="adeC CDS" gene 1402546..1404279 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /label="adeC gene" S_feature complement(1403674..1404278) /Source="Nicolas_S_feature" /locus_tag="new_1522479_1523083_c" /HighExp="Etha, C30, C90, dia15, LBGexp, Cold, dia5, S8, G180, S7" /AntisenseName="adeC" /AntisenseCor="-9.8927927273806792E-3" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S528" downshifts 1404268 /Source="Nicolas_upshifts" /id="D812" /incds=0 /nref=51 /ntot=223 /MaxReadThrough="1.93923" /MaxDrop="6.63088" /score="44.3452043" /energy="-19.5" /TU="NA" /idTUdmin="U1197" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1404313..1405980) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease J1" /protein_id="NP_389336.1" /db_xref="EnsemblGenomes-Gn:BSU14530" /db_xref="EnsemblGenomes-Tr:CAB13326" /db_xref="GOA:Q45493" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR001587" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="PDB:3ZQ4" /db_xref="SubtiList:BG11813" /db_xref="UniProtKB/Swiss-Prot:Q45493" /translation="MKFVKNDQTAVFALGGLGEIGKNTYAVQFQDEIVLIDAGIKFPE DELLGIDYVIPDYTYLVKNEDKIKGLFITHGHEDHIGGIPYLLRQVNIPVYGGKLAIG LLRNKLEEHGLLRQTKLNIIGEDDIVKFRKTAVSFFRTTHSIPDSYGIVVKTPPGNIV HTGDFKFDFTPVGEPANLTKMAEIGKEGVLCLLSDSTNSENPEFTMSERRVGESIHDI FRKVDGRIIFATFASNIHRLQQVIEAAVQNGRKVAVFGRSMESAIEIGQTLGYINCPK NTFIEHNEINRMPANKVTILCTGSQGEPMAALSRIANGTHRQISINPGDTVVFSSSPI PGNTISVSRTINQLYRAGAEVIHGPLNDIHTSGHGGQEEQKLMLRLIKPKFFMPIHGE YRMQKMHVKLATDCGIPEENCFIMDNGEVLALKGDEASVAGKIPSGSVYIDGSGIGDI GNIVLRDRRILSEEGLVIVVVSIDMDDFKISAGPDLISRGFVYMRESGDLINDAQELI SNHLQKVMERKTTQWSEIKNEITDTLAPFLYEKTKRRPMILPIIMEV*" /label="rnjA CDS" gene complement(1404313..1405980) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /label="rnjA gene" downshifts complement(1404323) /Source="Nicolas_upshifts" /id="D813" /incds=0 /nref=149 /ntot=269 /MaxReadThrough="4.3738" /MaxDrop="8.12983" /score="37.2074215" /energy="-19.5" /TU="U1199" /idTUdmin="U1200" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1405986..1406195) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /function="9.2: DNA-dependent RNA polymerase" /experiment="publication(s) with functional evidences, PMID:18289874, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18289874, 24187087; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega 1 subunit of RNA polymerase" /protein_id="NP_389337.1" /db_xref="EnsemblGenomes-Gn:BSU14540" /db_xref="EnsemblGenomes-Tr:CAB13327" /db_xref="InterPro:IPR009907" /db_xref="SubtiList:BG13335" /db_xref="UniProtKB/Swiss-Prot:O31718" /translation="MIYKVFYQEKADEVPVREKTDSLYIEGVSERDVRTKLKEKKFNI EFITPVDGAFLEYEQQSENFKVLEL*" /label="rnpZA CDS" gene complement(1405986..1406195) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /label="rnpZA gene" promotor_-10 complement(1406232..1406251) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1406254) /Source="Nicolas_upshifts" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1406256..1406433) /Source="Nicolas_S_feature" /locus_tag="new_1525061_1525238_c" /HighExp="S5, S8, S7, S6, S4, ferm, nit, T5.0H, HiTm, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97062099999999996" /TUshortSig="SigGF" /TUshortPSig="0.828" /TUlongSig="NA" /TUlongPSig="NA" /label="S529" promotor_-35 complement(1406266..1406269) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1406434) /Source="Nicolas_upshifts" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1406436..1406447) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1406461..1406467) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1406506..1406513 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1406527..1406546 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1406543 /Source="Nicolas_upshifts" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1406581..1407354 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389338.1" /db_xref="EnsemblGenomes-Gn:BSU14550" /db_xref="EnsemblGenomes-Tr:CAB13328" /db_xref="GOA:Q45494" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11814" /db_xref="UniProtKB/Swiss-Prot:Q45494" /translation="MDSKLIFFDIDGTIYDHDKNIPESTRKTVAELQRQGHHVFIASG RSPFLVKPILEELGIHSFISYNGQFVVFENQVIYKNPLPENAIRRLLKQADEGKHPVV FMAEDTMKATVADHPHVLEGIGSLKTDYPETDDLFYEGKEIFQLLLFCQDEEEKAYAA FPEFDLVRWHELSTDVLPHGGSKAEGIKKVIERLPFDIGDTYAFGDGLNDLQMIEYVG TGVAMGNAVPELKEIADFVTKPVDEDGIAYAVKELGLLK*" /label="ykrA CDS" gene 1406581..1407354 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /label="ykrA gene" downshifts 1407325 /Source="Nicolas_upshifts" /id="D814" /incds=0 /nref=184 /ntot=249 /MaxReadThrough="2.83896" /MaxDrop="6.20802" /score="28.5519453" /energy="-15.4" /TU="U1201" /idTUdmin="U1201" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1407390..1407944) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11429456, 16207374, 23944997, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16207374, 23944997, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-cysteine deformylase (promiscuous)" /protein_id="NP_389339.1" /db_xref="EnsemblGenomes-Gn:BSU14560" /db_xref="EnsemblGenomes-Tr:CAB13329" /db_xref="GOA:Q45495" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11815" /db_xref="UniProtKB/Swiss-Prot:Q45495" /translation="MITMENIVRDGHPALRETAEPVELPPTDAEKQQLADMIEFVKNS QNPELAEKYKLRPGVGLAAPQINIKKRMIAVHAEDASGKLYSYALFNPKIVSHSVEKS YLTSGEGCLSVDEAIPGYVPRYARIRVKGTTLEGENIDIRLKGFPAIVFQHEIDHLNG VMFYDHIDKENPFKEPENAIAIER*" /label="defB CDS" gene complement(1407390..1407944) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /label="defB gene" downshifts complement(1407401) /Source="Nicolas_upshifts" /id="D815" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="1.87469" /MaxDrop="5.89844" /score="28.3817715" /energy="-15.4" /TU="NA" /idTUdmin="U1202" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1407966..1407985) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1407976) /Source="Nicolas_upshifts" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1408000..1408007) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1408029 /Source="Nicolas_upshifts" /id="D816" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="0.95601" /MaxDrop="4.18336" /score="0.455865843" /energy="-17.1" /TU="NA" /idTUdmin="U1201" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(1408053) /Source="Nicolas_upshifts" /id="D817" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.11854" /MaxDrop="8.20445" /score="-8.94821426" /energy="-15.3" /TU="NA" /idTUdmin="U1204" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(1408054..1408212) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin (toxin I motif)" /protein_id="YP_003097725.1" /db_xref="EnsemblGenomes-Gn:BSU14569" /db_xref="EnsemblGenomes-Tr:CAX52616" /db_xref="GOA:C0H409" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H409" /translation="MYGYGYGGGCCSYGGYGYGGCGYGYGRTFALIVVLFILLIIVGA AYLGGGCC*" /label="ykzV CDS" gene complement(1408054..1408212) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /label="ykzV gene" CDS complement(1408119..1408262) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin" /protein_id="YP_009513955.1" /db_xref="EnsemblGenomes-Gn:BSU14568" /db_xref="EnsemblGenomes-Tr:CCQ48596" /db_xref="UniProtKB/TrEMBL:L8E9Z2" /translation="MPTYKGSGVIKRGGYVICMDMVTAEAAAVMVVTDMVAADMATAA PLR*" /label="putative antitoxin CDS" gene complement(1408119..1408262) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /label="gene" promotor_-35 1408208..1408212 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1408213..1408281) /Source="Nicolas_S_feature" /locus_tag="new_1527018_1527086_c" /HighExp="S8, S7, BT, S6, G/S, B36, Pyr, S5, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S530" promotor_-10 1408222..1408236 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1408249 /Source="Nicolas_upshifts" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1408265..1408284) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1408294) /Source="Nicolas_upshifts" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1408297..1408306) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1408368..1408375 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1408389..1408408 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1408393 /Source="Nicolas_upshifts" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1408426..1409097 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16684363, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389340.2" /db_xref="EnsemblGenomes-Gn:BSU14570" /db_xref="EnsemblGenomes-Tr:CAB13330" /db_xref="GOA:P21884" /db_xref="InterPro:IPR019454" /db_xref="InterPro:IPR036785" /db_xref="SubtiList:BG10206" /db_xref="UniProtKB/Swiss-Prot:P21884" /translation="MKDAIKRRPGIKIGAFCAMALILTGCMGQDPVDSLHHSLEKAAE SEKPFQEEQNTLKELEAKENQLYDSVMKLNMDDYKKIVALSNKALENVSKREEHLKLE NDSMKKSETEFEEAKTSAEHIKEKDIKEKADAAANHMEKRYTSYGTMYKEYKKALELN KKLYMQLKDKDLTRDDLDQQIDKVNASYEKILKYSGEFNEQTEKYNKAREDLYDAAGY RVKKS*" /label="ykyA CDS" gene 1408426..1409097 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /label="ykyA gene" promotor_-35 1408765..1408774 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1408787..1408805 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1408799 /Source="Nicolas_upshifts" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1409044 /Source="Nicolas_upshifts" /id="D818" /incds=0 /nref=96 /ntot=244 /MaxReadThrough="3.9299" /MaxDrop="6.03956" /score="20.6110953" /energy="-9.9" /TU="U1205" /idTUdmin="U1206" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 1409272..1409277 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1409294..1409313 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1409295..1409520 /Source="Nicolas_S_feature" /locus_tag="new_1528100_1528325" /HighExp="nit, MG-0.1, Diami, MG-0.2, ferm, dia5, Lbexp, dia0, Paraq, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S531" upshifts 1409295 /Source="Nicolas_upshifts" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1409299..1409318) /Source="Nicolas_upshift_promotors" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1409315) /Source="Nicolas_upshifts" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1409419..1409427) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1409425) /Source="Nicolas_upshifts" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1409441..1409449) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1409521..1410636 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /EC_number="1.2.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 alpha subunit)" /protein_id="NP_389341.1" /db_xref="EnsemblGenomes-Gn:BSU14580" /db_xref="EnsemblGenomes-Tr:CAB13331" /db_xref="GOA:P21881" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR017596" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10207" /db_xref="UniProtKB/Swiss-Prot:P21881" /translation="MAAKTKKAIVDSKKQFDAIKKQFETFQILNEKGEVVNEAAMPDL TDDQLKELMRRMVFTRVLDQRSISLNRQGRLGFYAPTAGQEASQIATHFALEKEDFVL PGYRDVPQLIWHGLPLYQAFLFSRGHFRGNQMPDDVNALSPQIIIGAQYIQTAGVALG LKKRGKKAVAITYTGDGGASQGDFYEGINFAGAYKAPAIFVVQNNRYAISTPVEKQSA AETIAQKAVAAGIVGVQVDGMDPLAVYAATAEARERAINGEGPTLIETLTFRYGPHTM AGDDPTKYRTKEIENEWEQKDPLVRFRAFLENKGLWSEEEEAKVIEDAKEEIKQAIKK ADAEPKQKVTDLMKIMYEKMPHNLEEQFEIYTQKESK*" /label="pdhA CDS" gene 1409521..1410636 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /label="pdhA gene" CDS 1410640..1411617 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /EC_number="1.2.4.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 9891797, 10735853, 11976308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 9891797, 10735853, 11976308; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 beta subunit)" /protein_id="NP_389342.1" /db_xref="EnsemblGenomes-Gn:BSU14590" /db_xref="EnsemblGenomes-Tr:CAB13332" /db_xref="GOA:P21882" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10208" /db_xref="UniProtKB/Swiss-Prot:P21882" /translation="MAQMTMIQAITDALRTELKNDENVLVFGEDVGVNGGVFRATEGL QKEFGEDRVFDTPLAESGIGGLALGLGLNGFRPVMEIQFFGFVYEVMDSVSGQMARMR YRSGGRWTSPVTIRSPFGGGVHTPELHADSLEGLVAQQPGIKVVIPSTPYDAKGLLIS AIRDNDPVVFLEHMKLYRSFRQEVPEEEYTIELGKADVKREGTDLSIITYGAMVHESL KAADELEKDGISAEVVDLRTVSPLDIDTIIASVEKTGRAIVVQEAQKQAGIAANVVAE INDRAILSLEAPVLRVAAPDTVFPFSQAESVWLPNHKDVLETARKVLEF*" /label="pdhB CDS" gene 1410640..1411617 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /label="pdhB gene" S_feature 1411618..1411731 /Source="Nicolas_S_feature" /locus_tag="new_1530423_1530536" /HighExp="G150, LBGexp, MG-0.1, G180, C30, Diami, Oxctl, G135, ferm, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S532" promotor_-10 complement(1411652..1411671) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1411669) /Source="Nicolas_upshifts" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1411686..1411689) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1411732..1413060 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /EC_number="2.3.1.12" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (dihydrolipoamide acetyltransferase E2 subunit)" /protein_id="NP_389343.1" /db_xref="EnsemblGenomes-Gn:BSU14600" /db_xref="EnsemblGenomes-Tr:CAB13333" /db_xref="GOA:P21883" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10209" /db_xref="UniProtKB/Swiss-Prot:P21883" /translation="MAFEFKLPDIGEGIHEGEIVKWFVKPNDEVDEDDVLAEVQNDKA VVEIPSPVKGKVLELKVEEGTVATVGQTIITFDAPGYEDLQFKGSDESDDAKTEAQVQ STAEAGQDVAKEEQAQEPAKATGAGQQDQAEVDPNKRVIAMPSVRKYAREKGVDIRKV TGSGNNGRVVKEDIDSFVNGGAQEAAPQETAAPQETAAKPAAAPAPEGEFPETREKMS GIRKAIAKAMVNSKHTAPHVTLMDEVDVTNLVAHRKQFKQVAADQGIKLTYLPYVVKA LTSALKKFPVLNTSIDDKTDEVIQKHYFNIGIAADTEKGLLVPVVKNADRKSVFEISD EINGLATKAREGKLAPAEMKGASCTITNIGSAGGQWFTPVINHPEVAILGIGRIAEKA IVRDGEIVAAPVLALSLSFDHRMIDGATAQNALNHIKRLLNDPQLILMEA*" /label="pdhC CDS" gene 1411732..1413060 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /label="pdhC gene" promotor_-35 1411876..1411883 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1411898..1411917 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1411901 /Source="Nicolas_upshifts" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="upshifts" CDS 1413065..1414477 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /EC_number="1.8.1.4" /EC_number="1.2.1.25" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 6815422, 9352926, 9588797, 12682299, 21856851" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 6815422, 9352926, 9588797, 12682299, 21856851; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="dihydrolipoamide dehydrogenase E3 subunit of both pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes" /protein_id="NP_389344.1" /db_xref="EnsemblGenomes-Gn:BSU14610" /db_xref="EnsemblGenomes-Tr:CAB13334" /db_xref="GOA:P21880" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10210" /db_xref="UniProtKB/Swiss-Prot:P21880" /translation="MVVGDFPIETDTLVIGAGPGGYVAAIRAAQLGQKVTVVEKATLG GVCLNVGCIPSKALINAGHRYENAKHSDDMGITAENVTVDFTKVQEWKASVVNKLTGG VAGLLKGNKVDVVKGEAYFVDSNSVRVMDENSAQTYTFKNAIIATGSRPIELPNFKYS ERVLNSTGALALKEIPKKLVVIGGGYIGTELGTAYANFGTELVILEGGDEILPGFEKQ MSSLVTRRLKKKGNVEIHTNAMAKGVEERPDGVTVTFEVKGEEKTVDADYVLITVGRR PNTDELGLEQVGIEMTDRGIVKTDKQCRTNVPNIYAIGDIIEGPPLAHKASYEGKIAA EAIAGEPAEIDYLGIPAVVFSEPELASVGYTEAQAKEEGLDIVAAKFPFAANGRALSL NETDGFMKLITRKEDGLVIGAQIAGASASDMISELSLAIEGGMTAEDIAMTIHAHPTL GEITMEAAEVAIGSPIHIVK*" /label="pdhD CDS" gene 1413065..1414477 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /label="pdhD gene" downshifts 1414474 /Source="Nicolas_upshifts" /id="D819" /incds=0 /nref=241 /ntot=268 /MaxReadThrough="1.82289" /MaxDrop="9.27853" /score="33.2247807" /energy="-12.1" /TU="NA" /idTUdmin="U1207" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1414522..1414896) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1936936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1936936; Product type s : structure" /codon_start=1 /transl_table=11 /product="small peptidoglycan-associated lipoprotein" /protein_id="NP_389345.1" /db_xref="EnsemblGenomes-Gn:BSU14620" /db_xref="EnsemblGenomes-Tr:CAB13335" /db_xref="GOA:P39910" /db_xref="SubtiList:BG10211" /db_xref="UniProtKB/Swiss-Prot:P39910" /translation="MRYRAVFPMLIIVFALSGCTLSTINPMKKSRIDNIHHTQILFFS DENQIDQEAPYYDALLDLEKDYPEQIDKMKVYDKKEGWEDEIETVPTLMVVDQRHVVV KIEGCVKKKEDIIKPLQHVLSK*" /label="slp CDS" gene complement(1414522..1414896) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /label="slp gene" downshifts complement(1414570) /Source="Nicolas_upshifts" /id="D820" /incds=0 /nref=26 /ntot=132 /MaxReadThrough="1.54024" /MaxDrop="3.69756" /score="4.23955997" /energy="-12.1" /TU="NA" /idTUdmin="U1212" /TUdmin=3 /isTUend="TRUE" /label="downshifts" misc_feature complement(1414927..1414946) /Source="Nicolas_upshift_promotors" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1414937) /Source="Nicolas_upshifts" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1415100..1415105 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-35" promotor_-10 1415121..1415139 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-10" upshifts 1415131 /Source="Nicolas_upshifts" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="upshifts" S_feature 1415135..1415244 /Source="Nicolas_S_feature" /locus_tag="new_1533940_1534049" /HighExp="S4, S5, S7, S6, S8, S3, BT, G/S, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S533" downshifts complement(1415167) /Source="Nicolas_upshifts" /id="D821" /incds=0 /nref=4 /ntot=18 /MaxReadThrough="1.96608" /MaxDrop="3.4036" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=308 /isTUend="FALSE" /label="downshifts" promotor_-35 1415228..1415235 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1415246 /Source="Nicolas_upshifts" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1415250..1415269 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1415265..1415475 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /product="small regulatory RNA and messenger RNA (argininemetabolism)" /experiment="publication(s) with functional evidences, PMID:16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348; Product type n: RNA" /function="16.3: Control" /label="srrA RNA" gene 1415265..1415475 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /label="srrA gene" CDS 1415315..1415434 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16164558, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 20444087, 27449348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of GapA synthesis" /protein_id="YP_003097726.1" /db_xref="EnsemblGenomes-Gn:BSU14629" /db_xref="EnsemblGenomes-Tr:CAX52617" /db_xref="InterPro:IPR025236" /db_xref="UniProtKB/Swiss-Prot:C0H410" /translation="MGTIVCQDCNEAIHYFEDEKVTTLYGTCCGQCQCPVDEE*" /label="rgpA CDS" gene 1415315..1415434 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /label="rgpA gene" downshifts complement(1415321) /Source="Nicolas_upshifts" /id="D822" /incds=0 /nref=6 /ntot=35 /MaxReadThrough="3.43398" /MaxDrop="4.36472" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts 1415421 /Source="Nicolas_upshifts" /id="D823" /incds=0 /nref=59 /ntot=171 /MaxReadThrough="5.69396" /MaxDrop="7.24152" /score="51.2534618" /energy="-16.8" /TU="U1214" /idTUdmin="U1213" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1415466..1417069 /Source="Nicolas_S_feature" /locus_tag="new_1534271_1535874" /HighExp="M9-stat, M0t90, B60, M40t90, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T0.30H" /AntisenseName="speA" /AntisenseCor="-0.33575411980382203" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.998" /label="S534" CDS complement(1415474..1416946) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /EC_number="4.1.1.19" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 19114526, 19255484, 20876533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 19114526, 19255484, 20876533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine decarboxylase" /protein_id="NP_389346.1" /db_xref="EnsemblGenomes-Gn:BSU14630" /db_xref="EnsemblGenomes-Tr:CAB13336" /db_xref="GOA:P21885" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10212" /db_xref="UniProtKB/Swiss-Prot:P21885" /translation="MSQHETPLYTGLKKHASRQPVQFHIPGHKKGAGMDPEFRQFIGE NALSIDLINIEPLDDLHAPKGIIKQAQDLAAEAFGADHTFFSVQGTSGAIMTMVMAVC GPGDKIIIPRNVHKSIMTAIVFSGAVPIFIHPEIDNELGISHGITLESAKRALTEHPD AKGLLVINPTYFGVAADLKSIVELAHSFDVPVLVDEAHGVHIHFHDELPLSAMQAGAD IAATSVHKLGGSLTQSSILNMREGLVSKDRVQSILSMLTTTSTSYLLLASLDVARKRL ATEGRQLAEETLKLANQTRDRLNQIEGIYCVGSEILGSKAAYSYDPTKLIISVKSLGL TGHDVEKWLRESFNIEVELSDLYNILCIFTPGDSQNDADRLVEALTEIAQQMSEQDVT HQQTEVLLPEIPLLAMTPRDAFYANTEVIPLKEASGRIIAEFVMVYPPGIPIFIPGEI ITEENISYIFKNLDAGLPVQGPEDSTLHMIRVIKEQKAIQ*" /label="speA CDS" gene complement(1415474..1416946) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /label="speA gene" downshifts complement(1415492) /Source="Nicolas_upshifts" /id="D824" /incds=0 /nref=62 /ntot=198 /MaxReadThrough="3.88498" /MaxDrop="6.76978" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" S_feature complement(1416947..1417042) /Source="Nicolas_S_feature" /locus_tag="new_1535752_1535847_c" /HighExp="Paraq, G180, LBGexp, Oxctl, G150, G135, C30, H2O2, BMM, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S535" promotor_-10 complement(1417025..1417044) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1417042) /Source="Nicolas_upshifts" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1417049..1417052 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1417059..1417066) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1417067..1417086 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1417071 /Source="Nicolas_upshifts" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="upshifts" CDS 1417131..1417397 /gene="yktA" /locus_tag="BSU_14640" /old_locus_tag="BSU14640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389347.1" /db_xref="EnsemblGenomes-Gn:BSU14640" /db_xref="EnsemblGenomes-Tr:CAB13337" /db_xref="InterPro:IPR007920" /db_xref="InterPro:IPR023324" /db_xref="SubtiList:BG11816" /db_xref="UniProtKB/Swiss-Prot:Q45497" /translation="MEYQYPMNEDWTTEEAVDVIAFFQQVELAYEKGADREELLKAYR RFKEIVPGKAEEKKLCGEFEEQSTYSPYRTVKQARESDHAKIKM*" /label="yktA CDS" gene 1417131..1417397 /gene="yktA" /locus_tag="BSU_14640" /old_locus_tag="BSU14640" /label="yktA gene" downshifts 1417379 /Source="Nicolas_upshifts" /id="D825" /incds=0 /nref=105 /ntot=250 /MaxReadThrough="2.62284" /MaxDrop="5.09814" /score="40.0811023" /energy="-16.1" /TU="NA" /idTUdmin="U1214" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1417430..1418068) /gene="yktB" /locus_tag="BSU_14650" /old_locus_tag="BSU14650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25643072" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389348.1" /db_xref="EnsemblGenomes-Gn:BSU14650" /db_xref="EnsemblGenomes-Tr:CAB13338" /db_xref="InterPro:IPR009403" /db_xref="PDB:2A8E" /db_xref="SubtiList:BG11817" /db_xref="UniProtKB/Swiss-Prot:Q45498" /translation="MTQMRFTEEDFNTFTIEGLDARMEVLKETVRPKLTALGEHFAPT LSALTGDEMFPHVAKHARRSVNPPADSWVAFANSKRGYKKLPHFQIGLWESHVFVWFA IIYESPIKEEYGKLLEVNQETITKNIPDSFVWSADHTKPGVHKQSEMDKEQLKTLFER LQTVKKAELLCGIQLQKEEVLNMNNQEFLQRIDDAFKQLAFLYRLTQKVTQA*" /label="yktB CDS" gene complement(1417430..1418068) /gene="yktB" /locus_tag="BSU_14650" /old_locus_tag="BSU14650" /label="yktB gene" downshifts complement(1417455) /Source="Nicolas_upshifts" /id="D826" /incds=0 /nref=184 /ntot=257 /MaxReadThrough="2.62959" /MaxDrop="6.54203" /score="26.7765804" /energy="-14.5" /TU="U1217" /idTUdmin="U1217" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1418089..1418108) /Source="Nicolas_upshift_promotors" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1418113) /Source="Nicolas_upshifts" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1418123..1418127) /Source="Nicolas_upshift_promotors" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1418138..1418144 /Source="Nicolas_upshift_promotors" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1418159..1418177 /Source="Nicolas_upshift_promotors" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1418160 /Source="Nicolas_upshifts" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1418198..1418207 /Source="Nicolas_upshift_promotors" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1418220..1418239 /Source="Nicolas_upshift_promotors" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1418224..1418307 /Source="Nicolas_S_feature" /locus_tag="new_1537029_1537112" /HighExp="Etha, S7, M9-stat, S6, S8, BT, Gly, Salt, B60, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S536" upshifts 1418224 /Source="Nicolas_upshifts" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="upshifts" CDS 1418308..1418496 /gene="ykzI" /locus_tag="BSU_14660" /old_locus_tag="BSU14660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved general stress protein" /protein_id="NP_389349.1" /db_xref="EnsemblGenomes-Gn:BSU14660" /db_xref="EnsemblGenomes-Tr:CAB13339" /db_xref="SubtiList:BG13337" /db_xref="UniProtKB/Swiss-Prot:O31719" /translation="MRQVVKEGFKEEKNNRVAVWRLEVDYELATLYEAMQKENEEQIE QSKNKLERLRKEWIRLNG*" /label="ykzI CDS" gene 1418308..1418496 /gene="ykzI" /locus_tag="BSU_14660" /old_locus_tag="BSU14660" /label="ykzI gene" downshifts complement(1418313) /Source="Nicolas_upshifts" /id="D827" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="1.50398" /MaxDrop="3.97385" /score="26.7765804" /energy="-14.5" /TU="NA" /idTUdmin="U1220" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1418489 /Source="Nicolas_upshifts" /id="D828" /incds=0 /nref=13 /ntot=45 /MaxReadThrough="7.33866" /MaxDrop="6.12123" /score="-8.73613673" /energy="-8.1" /TU="U1218,U1219" /idTUdmin="U1219" /TUdmin="-628" /isTUend="FALSE" /label="downshifts" upshifts complement(1418511) /Source="Nicolas_upshifts" /id="U1220" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.616383616383616" /psig="0.105894105894106" /xcortree=118 /SigmaFactorBS="agcaaggaaaatgaaaaatatcccttctcacgtaaaaacgaa ccattcaTGCGgttcgttttcactatcgcttttttacccgttaagacgaatccattct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1418519..1418522) /Source="Nicolas_upshift_promotors" /id="U1220" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.616383616383616" /psig="0.105894105894106" /xcortree=118 /SigmaFactorBS="agcaaggaaaatgaaaaatatcccttctcacgtaaaaacgaa ccattcaTGCGgttcgttttcactatcgcttttttacccgttaagacgaatccattct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1418566..1418569 /Source="Nicolas_upshift_promotors" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1418586..1418605 /Source="Nicolas_upshift_promotors" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1418589 /Source="Nicolas_upshifts" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="upshifts" CDS 1418636..1419433 /gene="suhB" /locus_tag="BSU_14670" /old_locus_tag="BSU14670" /EC_number="3.1.3.-" /EC_number="3.1.3.25" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914086, 16682444, 22333191, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914086, 16682444, 22333191, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inositol monophosphatase / 5' nucleotidase (purine nucleoside monophosphate)" /protein_id="NP_389350.1" /db_xref="EnsemblGenomes-Gn:BSU14670" /db_xref="EnsemblGenomes-Tr:CAB13340" /db_xref="GOA:Q45499" /db_xref="InterPro:IPR000760" /db_xref="InterPro:IPR020550" /db_xref="InterPro:IPR020583" /db_xref="InterPro:IPR033942" /db_xref="SubtiList:BG11818" /db_xref="UniProtKB/Swiss-Prot:Q45499" /translation="MTNWTEIDEIAKKWIREAGARITQSMHESLTIETKSNPNDLVTN IDKETEKFFIDRIQETFPGHRILGEEGQGDKIHSLEGVVWIIDPIDGTMNFVHQQRNF AISIGIFENGEGKIGLIYDVVHDELYHAFSGRGAYMNETKLAPLKETVIEEAILAINA TWVTENRRIDQSVLAPLVKRVRGTRSYGSAALELANVAAGRIDAYITMRLAPWDYAAG CVLLNEVGGTYTTIEGEPFTFLENHSVLAGNPSIHKTIFEEYLHARK*" /label="suhB CDS" gene 1418636..1419433 /gene="suhB" /locus_tag="BSU_14670" /old_locus_tag="BSU14670" /label="suhB gene" CDS 1419459..1419887 /gene="ykzC" /locus_tag="BSU_14680" /old_locus_tag="BSU14680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389351.1" /db_xref="EnsemblGenomes-Gn:BSU14680" /db_xref="EnsemblGenomes-Tr:CAB13341" /db_xref="GOA:O31720" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13331" /db_xref="UniProtKB/Swiss-Prot:O31720" /translation="MLEKLAEAHPVWKEEEFGDKDAEDYIISYSMYNGSWLVWEKDGM PVAVSYHLEWSPSNGKPWLGTVLIDPAEEKKGHAKMIIEQISKLLRAKHKAMFAGVPI ERREWILFLSQCGFEQLKTEKDEKGKSFMILVKPLAEAAV*" /label="ykzC CDS" gene 1419459..1419887 /gene="ykzC" /locus_tag="BSU_14680" /old_locus_tag="BSU14680" /label="ykzC gene" downshifts 1419844 /Source="Nicolas_upshifts" /id="D829" /incds=0 /nref=80 /ntot=232 /MaxReadThrough="4.50069" /MaxDrop="4.3098" /score="-9.99315734" /energy="-11.8" /TU="U1218,U1221" /idTUdmin="U1218" /TUdmin="-153" /isTUend="FALSE" /label="downshifts" S_feature 1419888..1420841 /Source="Nicolas_S_feature" /locus_tag="new_1538693_1539646" /HighExp="H2O2, dia15, Diami, Paraq, G180, G135, G150, dia5, Heat, LBGexp" /AntisenseName="yktD" /AntisenseCor="-1.5120906229522399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="0.117724" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S537" downshifts complement(1419963) /Source="Nicolas_upshifts" /id="D830" /incds=0 /nref=4 /ntot=85 /MaxReadThrough="0.88821" /MaxDrop="3.44773" /score="19.9363134" /energy="-12.8" /TU="NA" /idTUdmin="U1222" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1419965..1420879) /gene="yktD" /locus_tag="BSU_14690" /old_locus_tag="BSU14690" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_389352.1" /db_xref="EnsemblGenomes-Gn:BSU14690" /db_xref="EnsemblGenomes-Tr:CAB13342" /db_xref="GOA:Q45500" /db_xref="InterPro:IPR007213" /db_xref="InterPro:IPR011610" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11819" /db_xref="UniProtKB/Swiss-Prot:Q45500" /translation="MRKNESSLTSLISAFARAYHSRYDTPLIFDDFIAKDLINEKEFI DISKNMIQEISFFNKEIAERLQNDPEKILKWVAQIQLSPTPLARASYCEKVLHNELIL GAKQYVILGAGLDTFCFRHPELENSLQVFEVDHPATQQLKKNKLKDANLTIPGHLHFV PMDFTKTFSYDPLLDEGFKNTKTFFSLLGVSYYVTREENASLISNLFSHVPPGSSIVF DYADETLFTAKGTSNRVEHMVKMAAASGEPMKSCFTYQEIEHLLESSGLLIYEHLSPD DINDLFFSNRKDNLSAFETIHYIHAVKK*" /label="yktD CDS" gene complement(1419965..1420879) /gene="yktD" /locus_tag="BSU_14690" /old_locus_tag="BSU14690" /label="yktD gene" promotor_-10 complement(1420945..1420964) /Source="Nicolas_upshift_promotors" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1420953) /Source="Nicolas_upshifts" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1420979..1420986) /Source="Nicolas_upshift_promotors" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1421231..1422796) /gene="nprE" /locus_tag="BSU_14700" /old_locus_tag="BSU14700" /EC_number="3.4.24.28" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2128597, 6090407, 8436952, 15205417, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2128597, 6090407, 8436952, 15205417, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular neutral metalloprotease" /protein_id="NP_389353.1" /db_xref="EnsemblGenomes-Gn:BSU14700" /db_xref="EnsemblGenomes-Tr:CAB13343" /db_xref="GOA:P68736" /db_xref="InterPro:IPR001570" /db_xref="InterPro:IPR011096" /db_xref="InterPro:IPR013856" /db_xref="InterPro:IPR023612" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG10448" /db_xref="UniProtKB/Swiss-Prot:P68736" /translation="MGLGKKLSVAVAASFMSLSISLPGVQAAEGHQLKENQTNFLSKN AIAQSELSAPNDKAVKQFLKKNSNIFKGDPSKRLKLVESTTDALGYKHFRYAPVVNGV PIKDSQVIVHVDKSDNVYAVNGELHNQSAAKTDNSQKVSSEKALALAFKAIGKSPDAV SNGAAKNSNKAELKAIETKDGSYRLAYDVTIRYVEPEPANWEVLVDAETGSILKQQNK VEHAAATGSGTTLKGATVPLNISYEGGKYVLRDLSKPTGTQIITYDLQNRQSRLPGTL VSSTTKTFTSSSQRAAVDAHYNLGKVYDYFYSNFKRNSYDNKGSKIVSSVHYGTQYNN AAWTGDQMIYGDGDGSFFSPLSGSLDVTAHEMTHGVTQETANLIYENQPGALNESFSD VFGYFNDTEDWDIGEDITVSQPALRSLSNPTKYNQPDNYANYRNLPNTDEGDYGGVHT NSGIPNKAAYNTITKLGVSKSQQIYYRALTTYLTPSSTFKDAKAALIQSARDLYGSTD AAKVEAAWNAVGL*" /label="nprE CDS" gene complement(1421231..1422796) /gene="nprE" /locus_tag="BSU_14700" /old_locus_tag="BSU14700" /label="nprE gene" promotor_-10 complement(1422831..1422850) /Source="Nicolas_upshift_promotors" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1422842) /Source="Nicolas_upshifts" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1422864..1422871) /Source="Nicolas_upshift_promotors" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1423081..1425021 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16501307" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389354.1" /db_xref="EnsemblGenomes-Gn:BSU14710" /db_xref="EnsemblGenomes-Tr:CAB13344" /db_xref="GOA:O07625" /db_xref="SubtiList:BG13338" /db_xref="UniProtKB/Swiss-Prot:O07625" /translation="MLFVLELFSHYVLHFERYFILSRQSTLLIQWSIVVLAGLYLLVH HPKINRQRTMFLAGVILRIVLLAGVSVELIHQVQSTNFTSAYLREDGKELLPLLHFLL YGYVLLTAFHYMLMPRDHGGKGKFYTFDLAVVSLPIVQMIFSFFSYWKEYPDGMEPIA FVFLFFIITLPIALNVVFFKLYWRTDKILLGLFYTLIIGLLVLLLAPYPNQISKDYGA VMPYTIYLAMAGFLMSYHLFQKSGKVYVRVNKWVTMAVMVFFVLLLNPIYNIGTAAFA VSKPANVHDSFNFVGEHISSEKAEQILKSFFPTDETLYLHDTNMDVHYFYSFESKGYK AEVDEVSQLIRNYEYLQKAHGKKLTNQEYKRKSIAFLERHGRVLHKDHIETKVSQEDG QTVVRIYLKNQLHKKDHADDGAVFYWEKETLMGFSEDPSIYQLDSLLHVHITEQDIHD KVEQMFTALNISKQPYQITDIESDSLLGSMVRVETKVGIVLEFEGESGCLHSLSLPMK KNISMANSRLQHQILSIFDARGSEKKKKSSQGDMVMYTDSSKTYEFVEAQGQLNVYVY SDTPDQSFPYTYRNGTLAYEKVASLYQDVIYKKRMRPIIVQRGDERHYAWLIIIQPFG SNRHDAYVVDGETQEVKSLYES*" /label="ylaA CDS" gene 1423081..1425021 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /label="ylaA gene" CDS 1425011..1425280 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 16501307" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389355.1" /db_xref="EnsemblGenomes-Gn:BSU14720" /db_xref="EnsemblGenomes-Tr:CAB13345" /db_xref="GOA:O07626" /db_xref="SubtiList:BG13339" /db_xref="UniProtKB/Swiss-Prot:O07626" /translation="MNHKEKESVFVDLYDLYKEGELEDESMEWMKQHESLFQKNAEDL KSKTCLKRSPGAEEESQIRYMKVYLSSMYICFILLAIWMTVWFYF*" /label="ylaB CDS" gene 1425011..1425280 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /label="ylaB gene" promotor_-35 1425246..1425250 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1425264..1425283 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1425277 /Source="Nicolas_upshifts" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1425280..1425801 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF-type sigma factor" /protein_id="NP_389356.1" /db_xref="EnsemblGenomes-Gn:BSU14730" /db_xref="EnsemblGenomes-Tr:CAB13346" /db_xref="GOA:O07627" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13340" /db_xref="UniProtKB/Swiss-Prot:O07627" /translation="MKHRDSIEDLYRQYYQEILNYLFRRTHHLETAKDLAQDTFVKAL NGLASFRGHSSIRTWLYTIAHHTFINWYRRDVKYQFTEISKNEGLTQTTYDQPEQYLS RTVKSETLRQELLKLKDQHQSVLILREFQELSYEEIAEILGWSLSKVNTTLHRARLEL KKNMTKSREEERI*" /label="sigP CDS" gene 1425280..1425801 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /label="sigP gene" CDS 1425798..1426091 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-SigP(YlaC) sigma factor" /protein_id="NP_389357.1" /db_xref="EnsemblGenomes-Gn:BSU14740" /db_xref="EnsemblGenomes-Tr:CAB13347" /db_xref="GOA:O07628" /db_xref="InterPro:IPR027383" /db_xref="SubtiList:BG13341" /db_xref="UniProtKB/Swiss-Prot:O07628" /translation="MTCFLVRDLLPLYLEGDCKRETEHVIEEHLKMCSSCRDMYDTMA EPFELESEQAVEEAYLPEEELRFKQRYYGLLIMKAACWFGAAVAMMLIIKLLI*" /label="sigQ CDS" gene 1425798..1426091 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /label="sigQ gene" CDS complement(1426131..1426742) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389358.1" /db_xref="EnsemblGenomes-Gn:BSU14750" /db_xref="EnsemblGenomes-Tr:CAB13348" /db_xref="SubtiList:BG13342" /db_xref="UniProtKB/Swiss-Prot:O07629" /translation="MKKTFVKKAMLTTAAMTSAALLTFGPDAASAKTPVDNTAVQLQH QASTNEDLNTFIDILNQCIYEQDGVYYFDSEKAVELGMTKEEAQVIATLWESTSEFFS IVSQCVYLEDGNYKFDTEKAVELGFTEKEALALEQFFSAVSLKIHILQAAIVLQDDVY SYDKDAALQAGATPLQADVYEKLFSALSQEQLAAIYDMIHPQA*" /label="ylaE CDS" gene complement(1426131..1426742) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /label="ylaE gene" downshifts complement(1426145) /Source="Nicolas_upshifts" /id="D831" /incds=0 /nref=44 /ntot=184 /MaxReadThrough="1.37453" /MaxDrop="4.23106" /score="20.8244305" /energy="-11.7" /TU="NA" /idTUdmin="U1225" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1426774..1426793) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1426783) /Source="Nicolas_upshifts" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1426808..1426811) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1426998) /Source="Nicolas_upshifts" /id="D832" /incds=0 /nref=18 /ntot=138 /MaxReadThrough="2.72081" /MaxDrop="5.25382" /score="5.78870736" /energy="-8.3" /TU="NA" /idTUdmin="U1226" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" CDS complement(1427015..1427203) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389359.1" /db_xref="EnsemblGenomes-Gn:BSU14760" /db_xref="EnsemblGenomes-Tr:CAB13349" /db_xref="GOA:O07630" /db_xref="InterPro:IPR035211" /db_xref="SubtiList:BG13343" /db_xref="UniProtKB/Swiss-Prot:O07630" /translation="MKKMNWLLLLFAFAAVFSIMLIGVFIAEKSPAGIIASIVLVCAV MGGGFTLKKKMREQGLLD*" /label="ylaF CDS" gene complement(1427015..1427203) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /label="ylaF gene" downshifts complement(1427069) /Source="Nicolas_upshifts" /id="D833" /incds=0 /nref=9 /ntot=204 /MaxReadThrough="4.38484" /MaxDrop="3.2214" /score="5.78870736" /energy="-8.3" /TU="U1226" /idTUdmin="U1226" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1427225..1427244) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1427242) /Source="Nicolas_upshifts" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1427257..1427264) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1427270..1427289 /Source="Nicolas_upshift_promotors" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1427277 /Source="Nicolas_upshifts" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="upshifts" CDS 1427316..1429154 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11683274, 12399512, 9642082, 25135187, 26283392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-associated GTPase" /protein_id="NP_389360.1" /db_xref="EnsemblGenomes-Gn:BSU14770" /db_xref="EnsemblGenomes-Tr:CAB13350" /db_xref="GOA:O07631" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006298" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035651" /db_xref="SubtiList:BG13344" /db_xref="UniProtKB/Swiss-Prot:O07631" /translation="MKLRNDLRNIAIIAHVDHGKTTLVDQLLHQAGTFRANEQVAERA MDSNDLERERGITILAKNTAINYKDTRINILDTPGHADFGGEVERIMKMVDGVVLVVD AYEGCMPQTRFVLKKALEQNLNPVVVVNKIDRDFARPEEVIDEVLDLFIELDANEEQL EFPVVYASAINGTASLDPKQQDENMEALYETIIKHVPAPVDNAEEPLQFQVALLDYND YVGRIGIGRVFRGTMKVGQQVSLMKLDGTAKSFRVTKIFGFQGLKRVEIEEAKAGDLV AVSGMEDINVGETVCPVDHQDPLPVLRIDEPTLQMTFVVNNSPFAGREGKYVTARKIE ERLQSQLQTDVSLRVEPTASPDAWVVSGRGELHLSILIENMRREGYELQVSKPEVIIK EIDGVRCEPVERVQIDVPEEHTGSVMESMGARKGEMVDMINNGNGQVRLIFTVPSRGL IGYSTEFLSLTRGFGILNHTFDSYQPMQAGQVGGRRQGVLVSMENGKATSYGIQGIED RGVIFVEPGTEVYEGMIVGEHNRDNDLVVNVSKMKQQTNVRSATKDQTTTIKKARIMS LEESLEYLNEDEYCEVTPESIRLRKKILNKNEREKAAKKKKTAGLS*" /label="bipA CDS" gene 1427316..1429154 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /label="bipA gene" CDS 1429211..1429528 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unkown function" /protein_id="NP_389361.1" /db_xref="EnsemblGenomes-Gn:BSU14780" /db_xref="EnsemblGenomes-Tr:CAB13351" /db_xref="GOA:O07632" /db_xref="InterPro:IPR025620" /db_xref="SubtiList:BG13345" /db_xref="UniProtKB/Swiss-Prot:O07632" /translation="MNDVSERLSFFAALYQVDRQPAAGMWLLYGTIFVLAVIVFKLGF AKRLPVLKSAVVYVFLALGCTVLTFLGVFLPVAEGLVVAALILIIYKIRLYQSKKGQS AKS*" /label="ylaH CDS" gene 1429211..1429528 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /label="ylaH gene" downshifts 1429502 /Source="Nicolas_upshifts" /id="D834" /incds=0 /nref=241 /ntot=297 /MaxReadThrough="2.76511" /MaxDrop="7.50514" /score="29.8701447" /energy="-12.5" /TU="NA" /idTUdmin="U1227" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts complement(1429577) /Source="Nicolas_upshifts" /id="D835" /incds=0 /nref=240 /ntot=265 /MaxReadThrough="0.672690000000001" /MaxDrop="7.03405" /score="10.4340016" /energy="-12.5" /TU="NA" /idTUdmin="U1228" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1429584..1429793) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389362.1" /db_xref="EnsemblGenomes-Gn:BSU14790" /db_xref="EnsemblGenomes-Tr:CAB13352" /db_xref="InterPro:IPR019241" /db_xref="SubtiList:BG13346" /db_xref="UniProtKB/Swiss-Prot:O07633" /translation="MMRVKCSICDKIETIDDDTLIAKRLRNRPIHTYMCQECHDRIAK KTEERLKTGKFTFHPGQQKKEKVKK*" /label="ylaI CDS" gene complement(1429584..1429793) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /label="ylaI gene" misc_feature complement(1429807..1429826) /Source="Nicolas_upshift_promotors" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1429822) /Source="Nicolas_upshifts" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1429876..1430505) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_389363.1" /db_xref="EnsemblGenomes-Gn:BSU14800" /db_xref="EnsemblGenomes-Tr:CAB13353" /db_xref="GOA:O07634" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13347" /db_xref="UniProtKB/Swiss-Prot:O07634" /translation="MRILFIIIQLTLILSACAYQQGKQGQNVEKESTRQQETKPIHVK DTTQETKDNGTRTDIAKHLVSVAEKNPDVKDATAVVLGGYAVVGIDVDDTLDRSKVET IKYSVAQALKNDRYGANAVVIADPDTVSRLREMSREISEGHPVTGILDELAAIVGRVL PEVPNDVIDNEDEPQTKQQNDQLNRKQQQEMEKEQNDQSDHHMKKNNND*" /label="ylaJ CDS" gene complement(1429876..1430505) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /label="ylaJ gene" downshifts complement(1429907) /Source="Nicolas_upshifts" /id="D836" /incds=0 /nref=57 /ntot=112 /MaxReadThrough="1.90936" /MaxDrop="5.8475" /score="3.85709048" /energy="-7.2" /TU="NA" /idTUdmin="U1229" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1430407..1430425) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1430413) /Source="Nicolas_upshifts" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1430437..1430445) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1430540..1430551) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1430545) /Source="Nicolas_upshifts" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1430557..1430562 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-35" promotor_-35 complement(1430566..1430572) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1430578..1430596 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-10" upshifts 1430578 /Source="Nicolas_upshifts" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="upshifts" S_feature 1430579..1430659 /Source="Nicolas_S_feature" /locus_tag="new_1549384_1549464" /HighExp="S3, S5, S4, S8, S6, S7, LoTm, T5.0H, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S538" CDS 1430660..1431988 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12762842, 17114254; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phosphate starvation inducible protein" /protein_id="NP_389364.1" /db_xref="EnsemblGenomes-Gn:BSU14810" /db_xref="EnsemblGenomes-Tr:CAB13354" /db_xref="GOA:O07635" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG13348" /db_xref="UniProtKB/Swiss-Prot:O07635" /translation="MSKIYVLDTNVLLQDPNAIFSFEENEVVIPAVVLEEVDSKKRYM DEVGRNARHVSKLIDALRQKGRLHEHVPLDTGGTLRIELNHRSFHQLQEIFIEKTNDN RILAVAKNLSLEEETKENGRPVILVSKDVLVRVKADAIGLLAEDFLNDRVVDNDEMYS GYKDLYISQQLFSSFYGKNQISVNDVKQHAFYPNQFALMKDELGGSSSAVGIADKTGT VLKRLVFDDEHIWGIRPKNVQQTMALELLLREDIPLVTLIGKAGTGKTLLALAAGLLQ TEDLGIYKKLVVARPIVPVGKDIGYLPGEKEEKLKPWMQPIFDNLEFLFNAKKPGELD AILAGIGSIQVEALTYIRGRSIPDQFIIIDEAQNLTRHEVKTLLTRVGEGSKIVLMGD PEQIDHPYLDSLNNGLAYVVERFKGQPISGSVKLLKGERSGLAQLAADLL*" /label="ylaK CDS" gene 1430660..1431988 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /label="ylaK gene" S_feature complement(1431844..1431991) /Source="Nicolas_S_feature" /locus_tag="new_1550649_1550796_c" /HighExp="M40t90, M0t90, dia15, Lbtran, dia5, Etha, Mt0, Gly, LBGtran, LPhT" /AntisenseName="ylaK" /AntisenseCor="-0.66426410013570203" /AntisenseRegPval="-34.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S539" downshifts complement(1431887) /Source="Nicolas_upshifts" /id="D837" /incds=1 /nref=6 /ntot=67 /MaxReadThrough="3.81309" /MaxDrop="3.44499" /score="3.85709048" /energy="-7.2" /TU="U1232" /idTUdmin="U1232" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 1431989..1432579 /Source="Nicolas_S_feature" /locus_tag="new_1550794_1551384" /HighExp="S3, S4, S6, S5, S8, S7, BT, B36, LoTm, T5.0H" /AntisenseName="ylaL" /AntisenseCor="-0.79954210237955903" /AntisenseRegPval="-60.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S540" CDS complement(1431992..1432477) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389365.1" /db_xref="EnsemblGenomes-Gn:BSU14820" /db_xref="EnsemblGenomes-Tr:CAB13355" /db_xref="GOA:O07636" /db_xref="InterPro:IPR020229" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13349" /db_xref="UniProtKB/Swiss-Prot:O07636" /translation="MSVIQVKGNVTYPITIDPSVWIFDDRKFSFDRKGDSQDTYLQSA GDESDLDPERVIREGRIAPPTLKTEKQYEKQKLMNGSFAMRLGTVLKNAEPNSSATQC VFVTSSGKAAVSLETALNSIVHFSEAGKPIQEGGPVHIYFEDPVHHKQPITDVKEIEI I*" /label="ylaL CDS" gene complement(1431992..1432477) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /label="ylaL gene" promotor_-10 complement(1432489..1432508) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1432517) /Source="Nicolas_upshifts" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1432523..1432530) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1432580..1433509 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:18459799" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18459799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine amidohydrolase; glutaminase" /protein_id="NP_389366.1" /db_xref="EnsemblGenomes-Gn:BSU14830" /db_xref="EnsemblGenomes-Tr:CAB13356" /db_xref="GOA:O07637" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="SubtiList:BG13350" /db_xref="UniProtKB/Swiss-Prot:O07637" /translation="MVCQHNDELEALVKKAKKVTDKGEVASYIPALAKADKHDLSVAI YYSNNVCLSAGDVEKTFTLQSISKVLSLALVLMEYGKDKVFSYVGQEPTGDPFNSIIK LETVNPSKPLNPMINAGALVVTSLIRGRTVKERLDYLLSFIRRLTNNQEITYCREVAE SEYSTSMINRAMCYYMKQYGIFEDDVEAVMDLYTKQCAIEMNSLDLAKIGSVFALNGR HPETGEQVISKDVARICKTFMVTCGMYNASGEFAIKVGIPAKSGVSGGIMGISPYDFG IGIFGPALDEKGNSIAGVKLLEIMSEMYRLSIF*" /label="glsB CDS" gene 1432580..1433509 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /label="glsB gene" misc_feature 1433094..1433113 /Source="Nicolas_upshift_promotors" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1433103 /Source="Nicolas_upshifts" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="upshifts" promotor_-35 1433533..1433536 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1433551..1433570 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1433559 /Source="Nicolas_upshifts" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="upshifts" CDS 1433607..1433888 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12682299, 16880555, 17005971,17469204" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389367.1" /db_xref="EnsemblGenomes-Gn:BSU14840" /db_xref="EnsemblGenomes-Tr:CAB13357" /db_xref="InterPro:IPR009983" /db_xref="InterPro:IPR036270" /db_xref="SubtiList:BG13351" /db_xref="UniProtKB/Swiss-Prot:O07638" /translation="MASEMIVDHRQKAFELLKVDAEKILKLIRVQMDNLTMPQCPLYE EVLDTQMFGLSREIDFAVRLGLVDEKDGKDLLYTLERELSALHDAFTAK*" /label="ylaN CDS" gene 1433607..1433888 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /label="ylaN gene" downshifts 1433877 /Source="Nicolas_upshifts" /id="D838" /incds=0 /nref=72 /ntot=227 /MaxReadThrough="5.3857" /MaxDrop="6.58793" /score="2.26145837" /energy="-6.9" /TU="U1234" /idTUdmin="U1231" /TUdmin=328 /isTUend="FALSE" /label="downshifts" promotor_-35 1433951..1433954 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1433967..1434093 /Source="Nicolas_S_feature" /locus_tag="new_1552772_1552898" /HighExp="S1, T5.0H, T4.0H, HiOs, T3.30H, T3.0H, Etha, Heat, T2.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="0.619, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S541" upshifts 1433967 /Source="Nicolas_upshifts" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1433972..1433978 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1434094..1435305 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9622350, 12626683, 15849754, 16850406, 21386816, 27895631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 12626683, 15849754, 16850406, 21386816, 27895631; Product type t : transporter" /codon_start=1 /transl_table=11 /product="cell-division protein; transporter of lipid-linked cell wall precursors" /protein_id="NP_389368.1" /db_xref="EnsemblGenomes-Gn:BSU14850" /db_xref="EnsemblGenomes-Tr:CAB13358" /db_xref="GOA:O07639" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG13352" /db_xref="UniProtKB/Swiss-Prot:O07639" /translation="MLKKMLKSYDYSLIFAIVLLCGFGLVMVYSSSMITAVSRYGVSS NFFFMRQLFALIAGGALFILMALFPYKALAHQKFQKGILLVSVLALISLFVFGHVAGN AQSWFKIGGMSIQPGEFVKLVVILYLAAVYAKKQSYIDHLLTGVAPPVVMTLIICGLI AMQPDFGTAMIIGLIATCMILCSGFSGKTLVRLVILGGIVFILVSPIIYLNQDKILTE GRLARFESLEDPFKYANSSGLQVINSYYAISSGGIFGLGLGESIQKYGYLPESHTDFI MAVIAEELGIFGVLFVIFLLGFVVIKGFYIARKCEDPFGSLLAIGISSMIAIQSFINL GGVSGLIPITGVTLPFISYGGSSLVLLLGSMGILANISMFVKYSENKKKKEPLAPKGM KKKQLKKTVYL*" /label="ftsW CDS" gene 1434094..1435305 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /label="ftsW gene" promotor_-35 1435315..1435319 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1435334..1435353 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1435353 /Source="Nicolas_upshifts" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="upshifts" CDS 1435380..1438826 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /EC_number="6.4.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6425269, 15134465, 20081037, 20097852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate carboxylase" /protein_id="NP_389369.1" /db_xref="EnsemblGenomes-Gn:BSU14860" /db_xref="EnsemblGenomes-Tr:CAB13359" /db_xref="GOA:Q9KWU4" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR003379" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR005930" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG12660" /db_xref="UniProtKB/Swiss-Prot:Q9KWU4" /translation="MSQQSIQKVLVANRGEIAIRIFRACTELNIRTVAVYSKEDSGSY HRYKADEAYLVGEGKKPIDAYLDIEGIIDIAKRNKVDAIHPGYGFLSENIHFARRCEE EGIVFIGPKSEHLDMFGDKVKAREQAEKAGIPVIPGSDGPAETLEAVEQFGQANGYPI IIKASLGGGGRGMRIVRSESEVKEAYERAKSEAKAAFGNDEVYVEKLIENPKHIEVQV IGDKQGNVVHLFERDCSVQRRHQKVIEVAPSVSLSPELRDQICEAAVALAKNVNYINA GTVEFLVANNEFYFIEVNPRVQVEHTITEMITGVDIVQTQILVAQGHSLHSKKVNIPE QKDIFTIGYAIQSRVTTEDPQNDFMPDTGKIMAYRSGGGFGVRLDTGNSFQGAVITPY YDSLLVKLSTWALTFEQAAAKMVRNLQEFRIRGIKTNIPFLENVAKHEKFLTGQYDTS FIDTTPELFNFPKQKDRGTKMLTYIGNVTVNGFPGIGKKEKPAFDKPLGVKVDVDQQP ARGTKQILDEKGAEGLANWVKEQKSVLLTDTTFRDAHQSLLATRIRSHDLKKIANPTA ALWPELFSMEMWGGATFDVAYRFLKEDPWKRLEDLRKEVPNTLFQMLLRSSNAVGYTN YPDNVIKEFVKQSAQSGIDVFRIFDSLNWVKGMTLAIDAVRDTGKVAEAAICYTGDIL DKNRTKYDLAYYTSMAKELEAAGAHILGIKDMAGLLKPQAAYELVSALKETIDIPVHL HTHDTSGNGIYMYAKAVEAGVDIIDVAVSSMAGLTSQPSASGFYHAMEGNDRRPEMNV QGVELLSQYWESVRKYYSEFESGMKSPHTEIYEHEMPGGQYSNLQQQAKGVGLGDRWN EVKEMYRRVNDMFGDIVKVTPSSKVVGDMALYMVQNNLTEKDVYEKGESLDFPDSVVE LFKGNIGQPHGGFPEKLQKLILKGQEPITVRPGELLEPVSFEAIKQEFKEQHNLEISD QDAVAYALYPKVFTDYVKTTESYGDISVLDTPTFFYGMTLGEEIEVEIERGKTLIVKL ISIGEPQPDATRVVYFELNGQPREVVIKDESIKSSVQERLKADRTNPSHIAASMPGTV IKVLAEAGTKVNKGDHLMINEAMKMETTVQAPFSGTIKQVHVKNGEPIQTGDLLLEIE KA*" /label="pycA CDS" gene 1435380..1438826 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /label="pycA gene" promotor_-10 complement(1438392..1438410) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1438412) /Source="Nicolas_upshifts" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1438426..1438431) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1438806 /Source="Nicolas_upshifts" /id="D839" /incds=0 /nref=20 /ntot=213 /MaxReadThrough="5.5667" /MaxDrop="6.03063" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts 1438851 /Source="Nicolas_upshifts" /id="D840" /incds=0 /nref=2 /ntot=51 /MaxReadThrough="4.21552" /MaxDrop="4.9051" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=44 /isTUend="FALSE" /label="downshifts" downshifts complement(1438883) /Source="Nicolas_upshifts" /id="D841" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="2.24992" /MaxDrop="3.11732" /score="10.1921506" /energy="-11.8" /TU="NA" /idTUdmin="U1238" /TUdmin=330 /isTUend="FALSE" /label="downshifts" downshifts 1438895 /Source="Nicolas_upshifts" /id="D842" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="3.6246" /MaxDrop="4.10361" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(1439229..1440149) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /EC_number="1.3.-.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12206660, 15491161, 15849754, 16321940, 16850406, 26592143" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12206660, 15491161, 15849754, 16321940, 16850406, 26592143; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heme-A synthase" /protein_id="NP_389370.1" /db_xref="EnsemblGenomes-Gn:BSU14870" /db_xref="EnsemblGenomes-Tr:CAB13360" /db_xref="GOA:P12946" /db_xref="InterPro:IPR003780" /db_xref="InterPro:IPR023755" /db_xref="SubtiList:BG10213" /db_xref="UniProtKB/Swiss-Prot:P12946" /translation="MNKALKALGVLTTFVMLIVLIGGALVTKTGSGQGCGRQWPLCHG RFFPELNPASIIEWSHRFASGISIILVLSLAFWSWRKITPIFRETTFLAIMSIIFLFL QALLGALAVVFGSNALIMALHFGISLISFASVLILTLLIFEADKSVRTLVKPLQIGKK MQFHMIGILIYSYIVVYTGAYVRHTESSLACPNVPLCSPLNNGLPTQFHEWVQMGHRA AALLLFVWIIVAAVHAITSYKDQKQIFWGWISCLIFITLQALSGIMIVYSELALGFAL AHSFFIACLFGVLCYFLLLIARFRYESRQS*" /label="ctaA CDS" gene complement(1439229..1440149) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /label="ctaA gene" downshifts complement(1439235) /Source="Nicolas_upshifts" /id="D843" /incds=0 /nref=126 /ntot=238 /MaxReadThrough="2.72676" /MaxDrop="5.67271" /score="28.8671863" /energy="-15.3" /TU="U1238" /idTUdmin="U1238" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1440189..1440208) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1440204) /Source="Nicolas_upshifts" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1440222..1440229) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1440284..1440291 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1440305..1440324 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1440306..1440411 /Source="Nicolas_S_feature" /locus_tag="new_1559111_1559216" /HighExp="LBGstat, M0t90, Lbstat, BC, T0.30H, T1.30H, B60, M9-stat, M40t90, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S542" upshifts 1440306 /Source="Nicolas_upshifts" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" S_feature 1440413..1440503 /Source="Nicolas_S_feature" /locus_tag="new_1559218_1559308" /HighExp="LBGstat, M0t90, LPhT, BC, UNK1, BI, Lbexp, LBGtran, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S543" upshifts 1440413 /Source="Nicolas_upshifts" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1440419..1440422 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1440437..1440453 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1440504..1441421 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protoheme IX farnesyltransferase 2" /protein_id="NP_389371.1" /db_xref="EnsemblGenomes-Gn:BSU14880" /db_xref="EnsemblGenomes-Tr:CAB13361" /db_xref="GOA:P24009" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG10214" /db_xref="UniProtKB/Swiss-Prot:P24009" /translation="MANSRILNDTAIDGQIEETTAWKDFLSLIKIGIVNSNLITTFTG MWLALHISGLSFLGNINTVLLTLIGSSLIIAGSCAINNWYDRDIDHLMERTKVRPTVT GKIQPSQALWSGILLVALGLIMLLMTTVMAAVIGFIGVFTYVVLYTMWTKRRYTINTV VGSVSGAVPPLIGWTAVEGNIGVVAWVLFMILFIWQIPHFLALAIKKTEDYRAANIPM LPVVYGFEVTKRQIIVWVACLMPLPFFLGSLGLPIVILGLLLNIGWLILGLMGFRSKN IMKWATQMFVYSLNYMTIYFVAMVVLTLF*" /label="ctaB CDS" gene 1440504..1441421 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /label="ctaB gene" downshifts 1441450 /Source="Nicolas_upshifts" /id="D844" /incds=0 /nref=33 /ntot=75 /MaxReadThrough="8.35391" /MaxDrop="5.6457" /score="0.893081758" /energy="-11.8" /TU="U1239,U1240" /idTUdmin="U1236" /TUdmin=1719 /isTUend="FALSE" /label="downshifts" upshifts 1441469 /Source="Nicolas_upshifts" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1441470..1441475 /Source="Nicolas_upshift_promotors" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1441529..1441534 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1441549..1441567 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1441557..1441660 /Source="Nicolas_S_feature" /locus_tag="new_1560362_1560465" /HighExp="Lbstat, M0t90, M40t90, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, Sig-, SigA, SigA" /TUshortPSig="0.451, 0.407, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S544" upshifts 1441557 /Source="Nicolas_upshifts" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" CDS 1441661..1442731 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 9829923, 9882689, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 9829923, 9882689, 27503613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit II)" /protein_id="NP_389372.1" /db_xref="EnsemblGenomes-Gn:BSU14890" /db_xref="EnsemblGenomes-Tr:CAB13362" /db_xref="GOA:P24011" /db_xref="InterPro:IPR001505" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR014222" /db_xref="InterPro:IPR034236" /db_xref="InterPro:IPR036257" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10215" /db_xref="UniProtKB/Swiss-Prot:P24011" /translation="MVKHWRLILLLALVPLLLSGCGKPFLSTLKPAGEVADKQYDLTV LSTLIMVVVVAVVSVIFFYVIVRFRRSRVGENTIPKQVEGNKFLEITWTVIPILLLII LVIPVVLYTLELADTSPMDKKGRKAEDALVVNVRANLYWWEFEYPDYGIITSQELIVP TDQRVYFNLKASDVKHSFWIPSVGGKLDTNTDNENKFFLTFDSKRSKEAGDMFFGKCA ELCGPSHALMDFKVKTMSAKEFQGWTKEMKNYKSTAESDLAKQGEELFKEKNCLSCHA VEPNDKRAEAARTAPNLATFGERTKVAGVKEANKENVKAWLKDPDSIKPGNKMTGTYP KLSDSETNALYEYLKGLKAESK*" /label="ctaC CDS" gene 1441661..1442731 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /label="ctaC gene" CDS 1442764..1444632 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit I)" /protein_id="NP_389373.2" /db_xref="EnsemblGenomes-Gn:BSU14900" /db_xref="EnsemblGenomes-Tr:CAB13363" /db_xref="GOA:P24010" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014241" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10216" /db_xref="UniProtKB/Swiss-Prot:P24010" /translation="MLNALTEKRTRGSMLWDYLTTVDHKKIAILYLVAGGFFFLVGGI EAMFIRIQLAKPENAFLSAQAYNEVMTMHGTTMIFLAAMPLLFALMNAVVPLQIGARD VSFPFLNALGFWLFFFGGIFLNLSWFLGGAPDAGWTSYASLSLHSKGHGIDFFVLGLQ ISGLGTLIAGINFLATIINMRAPGMTYMRLPLFTWTTFVASALILFAFPPLTVGLALM MLDRLFGTNFFNPELGGNTVIWEHLFWIFGHPEVYILILPAFGIFSEVIPVFARKRLF GYSSMVFAIVLIGFLGFMVWVHHMFTTGLGPIANAIFAVATMAIAIPTGIKIFNWLLT IWGGNVKYTTAMLYAVSFIPSFVLGGVTGVMLAAAAADYQFHDTYFVVAHFHYVIIGG VVFGLLAGVHFWWPKMFGKILHETMGKISFVLFFIGFHLTFFIQHFVGLMGMPRRVYT FLPGQGLETGNLISTIGAFFMAAAVILLLVNVIWTSVKGEYVGADPWHDGRTLEWTVS SPPPEYNFKQLPFVRGLDPLWIEKQAGHKSMTPAEPVDDIHMPNGSILPLIISFGLFV AAFGLLYRSDYAWGLPVIFIGLGITFITMLLRSVIDDHGYHIHKEELPNDDKGVKA*" /label="ctaD CDS" gene 1442764..1444632 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /label="ctaD gene" CDS 1444632..1445255 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit III)" /protein_id="NP_389374.1" /db_xref="EnsemblGenomes-Gn:BSU14910" /db_xref="EnsemblGenomes-Tr:CAB13364" /db_xref="GOA:P24012" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10217" /db_xref="UniProtKB/Swiss-Prot:P24012" /translation="MQVQEKFTAETFPASPEKVTLEGKNKFLGFWLFLGGETVLFASL FATFLALRNSNAGDPPTTEMFDVTLVFIATMLLLTSSLTSVYAMYHMKNFSFGKMQLW LGITILLGAGFLGLEIYEFKHYTHEFGFTITSSALGSAFYTLVGTHGAHVAFGLMWIS TLMIRNAKRGLNLYTAPKFYVASLYWHFIDVVWVFIFTVVYLMGMVG*" /label="ctaE CDS" gene 1444632..1445255 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /label="ctaE gene" CDS 1445258..1445590 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit IV)" /protein_id="NP_389375.1" /db_xref="EnsemblGenomes-Gn:BSU14920" /db_xref="EnsemblGenomes-Tr:CAB13365" /db_xref="GOA:P24013" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014257" /db_xref="SubtiList:BG10218" /db_xref="UniProtKB/Swiss-Prot:P24013" /translation="MVDKKSRGHINSDLEFKKKKHAREMKYQVLSFGLMIGLTIVAFL TVATDGVGSWFTIPFIILLAAIQVIFQLYYFMHMNQKGHEAPALFLYSGVFVAFITVL AFVTIIWW*" /label="ctaF CDS" gene 1445258..1445590 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /label="ctaF gene" CDS 1445617..1446510 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /function="16.10: Respire" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14766920, 15849754, 16305244, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14766920, 15849754, 16305244, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome aa(3) assembly factor" /protein_id="NP_389376.1" /db_xref="EnsemblGenomes-Gn:BSU14930" /db_xref="EnsemblGenomes-Tr:CAB13366" /db_xref="GOA:O34329" /db_xref="InterPro:IPR014108" /db_xref="InterPro:IPR019108" /db_xref="SubtiList:BG12579" /db_xref="UniProtKB/Swiss-Prot:O34329" /translation="MNQLEIFGFRAMWSPYLFCILLGITALYLYFYRRMSSKPNRITG KEMVCFLSAMLFLYAAEGSPVDLLGHIMFSAHMVQMAVLYLVVPPLLIAGIPAWLWEK IIFRPSIKPVFSFFTTPLIALLLFNGIFSLYHVPLIFDTVKTDPFYHTLITWLIFVLA FFMWWPLVHKVERLRQLSGLMKLGYIMADGMLLTPACALIMFSGAPLYATYTDPALWA EAMRLCVPADMMGQVPLTGPEMLNTLPLLEDQQLGAVMMKIIQEIVYGTFLAVIFFQW VKKEREKDGQEEPPYIQQTIS*" /label="ctaG CDS" gene 1445617..1446510 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /label="ctaG gene" downshifts 1446485 /Source="Nicolas_upshifts" /id="D845" /incds=0 /nref=121 /ntot=229 /MaxReadThrough="1.94099" /MaxDrop="5.91271" /score="4.35633365" /energy="-13.3" /TU="NA" /idTUdmin="U1239" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1446542..1446904) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389377.1" /db_xref="EnsemblGenomes-Gn:BSU14940" /db_xref="EnsemblGenomes-Tr:CAB13367" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG13353" /db_xref="UniProtKB/Swiss-Prot:O34743" /translation="MLKFTESGLEGVKAELSWLDDLMESKGLIRAGQWDYERVTYDKK FSTIEGTFYLRIQGIAAEGDVGSGRAVIQLMSPLLGKHYYPHGVEYGETEEFPVQVVT KSKALIQDIANMLKTVQM*" /label="ylbA CDS" gene complement(1446542..1446904) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /label="ylbA gene" downshifts complement(1446561) /Source="Nicolas_upshifts" /id="D846" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="1.00586" /MaxDrop="6.68145" /score="-3.42191479" /energy="-11.2" /TU="NA" /idTUdmin="U1244" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1446897..1446901 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1446910..1446923 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1446928..1446947) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1446932..1447043 /Source="Nicolas_S_feature" /locus_tag="new_1565737_1565848" /HighExp="S7, S8, S4, S3, S6, S5, T5.0H, T4.0H, BC, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.368" /TUlongSig="NA" /TUlongPSig="NA" /label="S545" upshifts 1446932 /Source="Nicolas_upshifts" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1446940) /Source="Nicolas_upshifts" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1446962..1446969) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1447044..1447490 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389378.2" /db_xref="EnsemblGenomes-Gn:BSU14950" /db_xref="EnsemblGenomes-Tr:CAB13368" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG13354" /db_xref="UniProtKB/Swiss-Prot:O34682" /translation="MTKIKDLMTADLQYCTVLDNVYEAAVKMKDANVGAIPVVDEDGE TLVGIVTDRDLVLRGIAIKKPNSQKITDAMTEKPVSVEEDASVDEVLHLMASHQLRRI PVTKNKKLTGIVTLGDLSLSEQTNERAGSALSDISEGDNREEGFFH*" /label="ylbB CDS" gene 1447044..1447490 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /label="ylbB gene" promotor_-35 1447076..1447083 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1447095..1447114 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1447100 /Source="Nicolas_upshifts" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1447499..1447506 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1447520..1447539 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1447531 /Source="Nicolas_upshifts" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="upshifts" CDS 1447574..1448614 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389379.1" /db_xref="EnsemblGenomes-Gn:BSU14960" /db_xref="EnsemblGenomes-Tr:CAB13369" /db_xref="GOA:O34586" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR029410" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13355" /db_xref="UniProtKB/Swiss-Prot:O34586" /translation="MKNILRAMVILLIICGTYVLFIQYGSVPEKKSNDSEPQVSNEEA QSGKRIHMPTSGLLSFMGKHADEVTKKLGEPERIDPSAYDYDWWVYNQGKDQYIQIGV LNNKVVTLFASGNDINAKPFKIGESTGEVFKTTQVAPFVNVEYKGNSYRFEFSEEDIN TRPTVKVGKMYVQLYMDKFEGKLSSIRAFDAQTFVKQRPYEVVYRGELIKPKAVSDEK WKKIQTTSEKQILDLTNVIRVKHGLAKLEWDQPTAEVAFGHSEDMKENNYFSHVSKKY GSLKDRLEEGHVDFQQAGENIAYNYVDGPAAVEGWLNSEGHRKALLNSDYTHLGVGVD RKYYTQNFIKRW*" /label="ylbC CDS" gene 1447574..1448614 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /label="ylbC gene" promotor_-10 complement(1448537..1448555) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1448542) /Source="Nicolas_upshifts" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1448571..1448576) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1448594 /Source="Nicolas_upshifts" /id="D847" /incds=0 /nref=84 /ntot=252 /MaxReadThrough="1.59604" /MaxDrop="4.17709" /score="-1.16631837" /energy="-8.1" /TU="NA" /idTUdmin="U1243" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 1448778..1448787 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1448801..1448820 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1448815 /Source="Nicolas_upshifts" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="upshifts" CDS 1448846..1449244 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19775244, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related protein (coat)" /protein_id="NP_389380.1" /db_xref="EnsemblGenomes-Gn:BSU14970" /db_xref="EnsemblGenomes-Tr:CAB13370" /db_xref="InterPro:IPR025953" /db_xref="SubtiList:BG13356" /db_xref="UniProtKB/Swiss-Prot:O34880" /translation="MANQHANHSINDFKQFVKKHPKLIKEVRKEQRSWQDVYENWVLF GESDPIWDPYREPEEASEAVPETPQKNDFVSKMVTAVKKMDVNQMNEQINKMSQSISS LQSLLNTFSGSGQKHSQPGSGQHPFSFRKD*" /label="ylbD CDS" gene 1448846..1449244 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /label="ylbD gene" downshifts complement(1448850) /Source="Nicolas_upshifts" /id="D848" /incds=0 /nref=2 /ntot=11 /MaxReadThrough="2.37349" /MaxDrop="4.0378" /score="40.2648817" /energy="-14.3" /TU="NA" /idTUdmin="U1247" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS 1449260..1449499 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389381.1" /db_xref="EnsemblGenomes-Gn:BSU14980" /db_xref="EnsemblGenomes-Tr:CAB13371" /db_xref="InterPro:IPR025613" /db_xref="SubtiList:BG13357" /db_xref="UniProtKB/Swiss-Prot:O34958" /translation="MRKEVQEYILANEERKRFIREQPIWYRRLSRKPDDLSSFQLEMM NFYEKTIPHRVNQFTNGIQMAQMMMQMFQAMRTKD*" /label="ylbE CDS" gene 1449260..1449499 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /label="ylbE gene" downshifts 1449478 /Source="Nicolas_upshifts" /id="D849" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="2.09257" /MaxDrop="4.65792" /score="-7.8200921" /energy="-5.1" /TU="NA" /idTUdmin="U1248" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1449566..1449573 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1449584..1449603 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1449589 /Source="Nicolas_upshifts" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="upshifts" CDS 1449615..1450064 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex controlling RNase Y (RicAFTcomplex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389382.1" /db_xref="EnsemblGenomes-Gn:BSU14990" /db_xref="EnsemblGenomes-Tr:CAB13372" /db_xref="GOA:O34412" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="SubtiList:BG13358" /db_xref="UniProtKB/Swiss-Prot:O34412" /translation="MYATMESVRLQSEAQQLAEMILQSETAENYRNCYKRLQEDEEAG RIIRSFIKIKEQYEDVQRFGKYHPDYREISRKMREIKRELDLNDKVADFKRAENELQS ILDEVSVEIGTAVSEHVKVPTGNPYFDGLSSCGGGCGSGGSCGCKVS*" /label="ricF CDS" gene 1449615..1450064 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /label="ricF gene" downshifts 1450050 /Source="Nicolas_upshifts" /id="D850" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="5.95111" /MaxDrop="2.83" /score="-4.2014677" /energy="-11.5" /TU="U1249" /idTUdmin="U1248" /TUdmin=572 /isTUend="FALSE" /label="downshifts" CDS 1450119..1450391 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10712692, 21532344, 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389383.1" /db_xref="EnsemblGenomes-Gn:BSU15000" /db_xref="EnsemblGenomes-Tr:CAB13373" /db_xref="GOA:O34658" /db_xref="InterPro:IPR016979" /db_xref="SubtiList:BG13359" /db_xref="UniProtKB/Swiss-Prot:O34658" /translation="MENRRQGMVVYLHSLKQSKMLRKFGNVHYVSKRLKYVVLYCDMD QIEKTMDKIASYSFVKKVEPSYKPFLKLEFESKLDKAKEYDYKIGI*" /label="ylbG CDS" gene 1450119..1450391 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /label="ylbG gene" S_feature complement(1450196..1450419) /Source="Nicolas_S_feature" /locus_tag="new_1569001_1569224_c" /HighExp="S8, S7, S4, S5, S6, S3, C30, BT, G135, C90" /AntisenseName="ylbG" /AntisenseCor="-0.668594452827031" /AntisenseRegPval="-35.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S546" misc_RNA 1450394..1450514 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /product="sporulation-specific regulatory RNA" /experiment="publication(s) with functional evidences, PMID:21532344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21532344; Product type n: RNA" /function="15.7: Sporulation and germination" /label="csfG RNA" gene 1450394..1450514 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /label="csfG gene" S_feature complement(1450421..1450544) /Source="Nicolas_S_feature" /locus_tag="new_1569226_1569349_c" /HighExp="S3, S8, S7, G/S, S4, S5, Pyr, S6, B36, BT" /AntisenseName="NA" /AntisenseCor="-0.69279578575099399" /AntisenseRegPval="-39.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S547" downshifts complement(1450464) /Source="Nicolas_upshifts" /id="D851" /incds=0 /nref=61 /ntot=131 /MaxReadThrough="3.9368" /MaxDrop="7.78892" /score="40.2648817" /energy="-14.3" /TU="U1250" /idTUdmin="U1250" /TUdmin="-228" /isTUend="FALSE" /label="downshifts" S_feature 1450515..1450620 /Source="Nicolas_S_feature" /locus_tag="new_1569320_1569425" /HighExp="H2O2, Paraq, Oxctl, G180, G135, G150, Cold, C30, Diami, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S548" promotor_-10 complement(1450545..1450557) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1450552) /Source="Nicolas_upshifts" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1450572..1450578) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1450601..1450605 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-35" promotor_-10 1450621..1450640 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-10" S_feature 1450622..1450713 /Source="Nicolas_S_feature" /locus_tag="new_1569427_1569518" /HighExp="H2O2, G135, Oxctl, Paraq, G180, dia0, G150, Lbexp, LBGexp, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S549" upshifts 1450622 /Source="Nicolas_upshifts" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="upshifts" CDS 1450714..1451268 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /EC_number="2.1.1.171" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 17389639, 22535590, 22649054; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m2G966 methyltransferase" /protein_id="NP_389384.2" /db_xref="EnsemblGenomes-Gn:BSU15010" /db_xref="EnsemblGenomes-Tr:CAB13374" /db_xref="GOA:O34331" /db_xref="InterPro:IPR004398" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13360" /db_xref="UniProtKB/Swiss-Prot:O34331" /translation="MRVISGSKKGRSLKAVAGTSTRPTTDKVKESIFNMIGPYFDGGR GLDLFAGSGGLGIEALSRGFEHCIFVDRDFKAIQTVKSNLKTLELTKHAQVYRNDAER ALHAAAKRETGFRGIFLDPPYKEQKLKALLTLIDEYQMLEEDGFIVAEHDREVELPET VGDLVMTRKETYGLTGVAIYKKRG*" /label="rsmD CDS" gene 1450714..1451268 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /label="rsmD gene" CDS 1451273..1451758 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /EC_number="2.7.7.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10480925, 10939241, 16014871, 21912874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphopantetheine adenylyltransferase" /protein_id="NP_389385.1" /db_xref="EnsemblGenomes-Gn:BSU15020" /db_xref="EnsemblGenomes-Tr:CAB13375" /db_xref="GOA:O34797" /db_xref="InterPro:IPR001980" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="PDB:1O6B" /db_xref="SubtiList:BG13361" /db_xref="UniProtKB/Swiss-Prot:O34797" /translation="MASIAVCPGSFDPVTYGHLDIIKRGAHIFEQVYVCVLNNSSKKP LFSVEERCELLREVTKDIPNITVETSQGLLIDYAKRKNAKAILRGLRAVSDFEYEMQG TSVNRVLDESIETFFMMTNNQYSFLSSSIVKEVARYNGSVSEFVPPEVELALQQKFRQ G*" /label="coaD CDS" gene 1451273..1451758 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /label="coaD gene" downshifts 1451725 /Source="Nicolas_upshifts" /id="D852" /incds=0 /nref=26 /ntot=196 /MaxReadThrough="3.45558" /MaxDrop="3.85134" /score="13.7782945" /energy="-7.8" /TU="U1249,U1251" /idTUdmin="U1251" /TUdmin="-1296" /isTUend="FALSE" /label="downshifts" CDS complement(1451769..1452995) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15849754, 16850406, 28945739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15849754, 16850406, 28945739; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipicolinic acid transporter (to the spore)" /protein_id="NP_389386.1" /db_xref="EnsemblGenomes-Gn:BSU15030" /db_xref="EnsemblGenomes-Tr:CAB13376" /db_xref="GOA:O34765" /db_xref="InterPro:IPR011642" /db_xref="InterPro:IPR014226" /db_xref="SubtiList:BG13362" /db_xref="UniProtKB/Swiss-Prot:O34765" /translation="MNLSKINTLLIASFFLFLTATVISHPQASFEASKTGLSMWWEVV FPSLLPFFILSELLIGFGIVRFVGVLLEPFMRPIFRVPGVGGFVLAMGMASGNPAGAK LTARLRQENQISRVEAERLASFTNSSNPLFIFGAVAVGFFQNASLGILLASAHYLGNL AVGLTMRSYGRKEEQHLRRKKTIPFPSVKDALHALHTARLAEKRPLGKILGDAVTSSV QTLLMVGGFIILFSVFNRLLSVVQLTDVLSVFTKGALTLFQLPTQLDIPLLSGMFEIT LGSKLVSETDVSLLQKAIIVSFILGFSGFSVQAQVAGILSETDIRFKPFFIARLLQGV YAAVFVMLLWKPLYTAWHDPYQYVFKSLNSSDMSTAFINGWNLLVQIGPAVTLCALFT YIIIFSYRLTNGTKKG*" /label="spoVV CDS" gene complement(1451769..1452995) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /label="spoVV gene" S_feature 1451770..1453044 /Source="Nicolas_S_feature" /locus_tag="new_1570575_1571849" /HighExp="H2O2, G135, Paraq, G150, G180, Oxctl, LBGexp, dia0, dia15, Mt0" /AntisenseName="ylbJ" /AntisenseCor="-0.54237424349391605" /AntisenseRegPval="-21.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S550" S_feature complement(1452996..1453097) /Source="Nicolas_S_feature" /locus_tag="new_1571801_1571902_c" /HighExp="LoTm, S3, S4, S5, T5.0H, M9-stat, T4.0H, S6, BT, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S551" promotor_-35 1453019..1453026 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1453038..1453057 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1453046..1453175 /Source="Nicolas_S_feature" /locus_tag="new_1571851_1571980" /HighExp="Etha, dia15, dia5, Diami, H2O2, Lbtran, LBGtran, Paraq, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S552" upshifts 1453046 /Source="Nicolas_upshifts" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1453092..1453110) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1453107) /Source="Nicolas_upshifts" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1453127..1453132) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1453176..1453958 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389387.1" /db_xref="EnsemblGenomes-Gn:BSU15040" /db_xref="EnsemblGenomes-Tr:CAB13377" /db_xref="GOA:O34731" /db_xref="InterPro:IPR001423" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG13363" /db_xref="UniProtKB/Swiss-Prot:O34731" /translation="MAKPKIGLALGSGGARGLAHLGVLSSLHKHQIEVDMIAGSSMGA LVGSFYAAGHDVATMKKVAKAFKRRLYADYTVPKLGFLKGDRVRQLVHAYTFGKPIEE LQIPLGIVACDLQTGEKIVFRKGSVSDAVRASISIPGIFIPQRLDGRLLVDGAVVDRI PVSVVKDMGADIIIASDVSRVRKTETAVHIFDVIMQSMDILQNELVRHQTIAADIMIR PSLETYSSSSFANIEEMISAGEEATNRMISKIRKEIENWEGS*" /label="ylbK CDS" gene 1453176..1453958 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /label="ylbK gene" promotor_-35 1453738..1453744 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1453758..1453769 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1453769 /Source="Nicolas_upshifts" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="upshifts" CDS 1453960..1454985 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradative enzyme" /protein_id="NP_389388.2" /db_xref="EnsemblGenomes-Gn:BSU15050" /db_xref="EnsemblGenomes-Tr:CAB13378" /db_xref="GOA:O34470" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR036034" /db_xref="PDB:2KJP" /db_xref="SubtiList:BG13364" /db_xref="UniProtKB/Swiss-Prot:O34470" /translation="MLRKKHFSWMLVILILIAVLSFIKLPYYITKPGEATELASLIKV EGGYPEKGSLSLMTVKVGPANPFTYVWAKMHPYYEIVPDESIKEEGESDKEYMKRQLQ MMKSSQENAVIAAYQKAGKKVSYSFNGIYASSVVENMPAKGKIEVGDKIISADGKNYQ SAEKLIDYISSKKAGDKVTLKIEREEKEKRVTLTLKQFPDEPDRAGIGVSLYTDRNVK VEPDIDFEIENIGGPSAGLMMSLEIYNQLTKPDETKGYDIAGTGTIDVDGKVGPIGGI DQKVVAADKAGKDIFFAPNQNGASNSDYKNAVKTAKDIDSNMKIVPVDTMQDAIDYLN KLKAKST*" /label="ylbL CDS" gene 1453960..1454985 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /label="ylbL gene" downshifts 1454869 /Source="Nicolas_upshifts" /id="D853" /incds=1 /nref=59 /ntot=235 /MaxReadThrough="2.38639" /MaxDrop="3.52503" /score="19.0874959" /energy="-11.5" /TU="NA" /idTUdmin="U1249" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1455002..1456249) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 19215769; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative component of the degradosome" /protein_id="NP_389389.1" /db_xref="EnsemblGenomes-Gn:BSU15060" /db_xref="EnsemblGenomes-Tr:CAB13379" /db_xref="InterPro:IPR008513" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13365" /db_xref="UniProtKB/Swiss-Prot:O34513" /translation="MKAVGLVVEYNPFHNGHLYHAQTAKLQTGCDTAVAVMSGHFLQR GEPAVVSKWARTKMALQSGVDLVIELPYLYAVQKADIFARGSVSILNELECEALFFGS ENGDIKPFLETAQLIDEHKHILNDRIKEELKKGASYPAAAAIAFSSILHTESALDLSK PNNILGYQYVTSILTGGYPMKPYTTARISSDYHDADLPEGENHIASATSIRKAMIGQN LEACLRFLPAASARELAAYRKSFGLWHTPESYFSYLKYSLSTVTARELQQVYEVEEGL EHRIIRSIRKSSSYQEFMELLKTKRYTWTRLQRMNTHILTRTKKQDMQKLLDNDKAPY IRLLGMTKKGQAYLSEKKKALSVPLVSKLSSFSHPALDLDVKASRIYSLPIEEPLRTE FDLQEYGHAPIRYDEDEQHFLNV*" /label="ylbM CDS" gene complement(1455002..1456249) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /label="ylbM gene" downshifts complement(1455029) /Source="Nicolas_upshifts" /id="D854" /incds=0 /nref=8 /ntot=182 /MaxReadThrough="1.58661" /MaxDrop="3.70777" /score="4.49214865" /energy="-11.5" /TU="NA" /idTUdmin="U1257" /TUdmin=775 /isTUend="FALSE" /label="downshifts" promotor_-35 1456166..1456172 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-35" promotor_-10 1456186..1456197 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-10" upshifts 1456190 /Source="Nicolas_upshifts" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="upshifts" CDS complement(1456246..1456431) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein,of unknown function" /protein_id="YP_003097727.1" /db_xref="EnsemblGenomes-Gn:BSU15069" /db_xref="EnsemblGenomes-Tr:CAX52618" /db_xref="UniProtKB/Swiss-Prot:C0H411" /translation="MIIAFKIVFVNIFSLQHNAAIEVSLTAEYAMHTLKTKIRRKSFH LQMYHTFLNIARKAEKI*" /label="ylzH CDS" gene complement(1456246..1456431) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /label="ylzH gene" promotor_-35 1456264..1456268 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-35" promotor_-10 1456284..1456303 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-10" S_feature 1456293..1456428 /Source="Nicolas_S_feature" /locus_tag="new_1575098_1575233" /HighExp="Cold, LoTm, Diami, Paraq, H2O2, Oxctl, G180, dia5, G135, LBGexp" /AntisenseName="ylzH" /AntisenseCor="-9.1134498265910996E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S553" upshifts 1456293 /Source="Nicolas_upshifts" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="upshifts" promotor_-10 complement(1456322..1456341) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1456332) /Source="Nicolas_upshifts" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1456355..1456362) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1456399..1456406 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1456420..1456439 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1456430 /Source="Nicolas_upshifts" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="upshifts" CDS 1456459..1456977 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11700356, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389390.1" /db_xref="EnsemblGenomes-Gn:BSU15070" /db_xref="EnsemblGenomes-Tr:CAB13380" /db_xref="InterPro:IPR003772" /db_xref="SubtiList:BG13366" /db_xref="UniProtKB/Swiss-Prot:O34445" /translation="MKWTIYQLHQMPKQSFEFDETVELNELTKLNSDIRRISPVRVKG RADIKSKQVSFDFTISGEMLLPCSRTLVDVPYPFEISTKELFIFHHTDDIEDDDVHIV EDDTIDITPIVKEEILLEIPMQIFCESEQEKGAAPQEGKDWQVISEEDKKNQVDPRLA ALEKLLKQDDES*" /label="ylbN CDS" gene 1456459..1456977 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /label="ylbN gene" CDS 1456999..1457178 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L32" /protein_id="NP_389391.1" /db_xref="EnsemblGenomes-Gn:BSU15080" /db_xref="EnsemblGenomes-Tr:CAB13381" /db_xref="GOA:O34687" /db_xref="InterPro:IPR002677" /db_xref="InterPro:IPR011332" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12668" /db_xref="UniProtKB/Swiss-Prot:O34687" /translation="MAVPFRRTSKMKKRLRRTHFKLNVPGMTECPSCGEMKLSHRVCK ACGSYNGKDINVKSN*" /label="rpmF CDS" gene 1456999..1457178 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /label="rpmF gene" downshifts 1457158 /Source="Nicolas_upshifts" /id="D855" /incds=0 /nref=232 /ntot=266 /MaxReadThrough="5.64002" /MaxDrop="7.70407" /score="53.0065581" /energy="-17.1" /TU="U1258" /idTUdmin="U1256" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1457201) /Source="Nicolas_upshifts" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1457205..1457208) /Source="Nicolas_upshift_promotors" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1457259..1457264 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1457280..1457298 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1457281 /Source="Nicolas_upshifts" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="upshifts" CDS 1457324..1457905 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15621419, 20435725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15621419, 20435725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="DNA-binding regulator" /protein_id="NP_389392.1" /db_xref="EnsemblGenomes-Gn:BSU15090" /db_xref="EnsemblGenomes-Tr:CAB13382" /db_xref="GOA:O34549" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017930" /db_xref="SubtiList:BG13367" /db_xref="UniProtKB/Swiss-Prot:O34549" /translation="MTITRQDAWTQDEDLLLAEVVLRHIREGGTQLSAFEEVGRALTR TAAACGFRWNSYVRKQYQSGIELAKKQRKELRKQIGVHSVNMPNSMKQTASASSEGKR DLSIQDVIQFLEQFKETPSAQEFQLEREKLKEQIQSLQKELEDLRSENQTLRNQLEMT EEDYKALIDIMDRARKMVVSKEDGRMKKAAQET*" /label="gerR CDS" gene 1457324..1457905 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /label="gerR gene" downshifts 1457906 /Source="Nicolas_upshifts" /id="D856" /incds=0 /nref=56 /ntot=139 /MaxReadThrough="2.70626" /MaxDrop="5.6861" /score="-7.71867756" /energy="-12.8" /TU="U1260" /idTUdmin="U1258" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1457962..1458444) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389393.2" /db_xref="EnsemblGenomes-Gn:BSU15100" /db_xref="EnsemblGenomes-Tr:CAB13383" /db_xref="GOA:O34468" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017274" /db_xref="PDB:2PR1" /db_xref="SubtiList:BG13368" /db_xref="UniProtKB/Swiss-Prot:O34468" /translation="MTKVERLLINYKTLEEFKKFKEYGIQELSMLEELQDNIIENDST SPFYGIYFGDKLVARMSLYQVNGKSNPYFDNRQDYLELWKLEVLPGYQNRGYGRALVE FAKSFKMPIRTNPRMKSAEFWNKMNFKTVKYDMARDKGENPLIWHPDMDREMTPGESA *" /label="ylbP CDS" gene complement(1457962..1458444) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /label="ylbP gene" downshifts complement(1457981) /Source="Nicolas_upshifts" /id="D857" /incds=0 /nref=90 /ntot=231 /MaxReadThrough="3.90092" /MaxDrop="6.59996" /score="14.5482917" /energy="-14.5" /TU="U1261" /idTUdmin="U1261" /TUdmin="-615" /isTUend="FALSE" /label="downshifts" downshifts 1458434 /Source="Nicolas_upshifts" /id="D858" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.3013" /MaxDrop="4.42908" /score="-7.71867756" /energy="-12.8" /TU="NA" /idTUdmin="U1260" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1458467..1458486) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1458486) /Source="Nicolas_upshifts" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1458500..1458507) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1458544..1458550 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-35" promotor_-10 1458562..1458581 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-10" upshifts 1458564 /Source="Nicolas_upshifts" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="upshifts" CDS 1458604..1459500 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1844812, 10736170, 23894131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1844812, 10736170, 23894131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate 2-reductase" /protein_id="NP_389394.1" /db_xref="EnsemblGenomes-Gn:BSU15110" /db_xref="EnsemblGenomes-Tr:CAB13384" /db_xref="GOA:O34661" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="PDB:3EGO" /db_xref="SubtiList:BG13369" /db_xref="UniProtKB/Swiss-Prot:O34661" /translation="MKIGIIGGGSVGLLCAYYLSLYHDVTVVTRRQEQAAAIQSEGIR LYKGGEEFRADCSADTSINSDFDLLVVTVKQHQLQSVFSSLERIGKTNILFLQNGMGH IHDLKDWHVGHSIYVGIVEHGAVRKSDTAVDHTGLGAIKWSAFDDAEPDRLNILFQHN HSDFPIYYETDWYRLLTGKLIVNACINPLTALLQVKNGELLTTPAYLAFMKLVFQEAC RILKLENEEKAWERVQAVCGQTKENRSSMLVDVIGGRQTEADAIIGYLLKEASLQGLD AVHLEFLYGSIKALERNTNKVF*" /label="panE CDS" gene 1458604..1459500 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /label="panE gene" CDS 1459571..1461190 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /EC_number="6.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16169927, 19578333, 20308541, 20799687, 25496067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16169927, 19578333, 20308541, 20799687, 25496067; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate glucosamine cysteine ligase" /protein_id="NP_389395.2" /db_xref="EnsemblGenomes-Gn:BSU15120" /db_xref="EnsemblGenomes-Tr:CAB13385" /db_xref="GOA:P55342" /db_xref="InterPro:IPR011199" /db_xref="PDB:4WBD" /db_xref="SubtiList:BG11424" /db_xref="UniProtKB/Swiss-Prot:P55342" /translation="MQLTELSIKNQNVFVQHYIDGKEEMSSFFDYSIHHKDMWRERLE DLSSRFFAREELAAYLTSYHNKFGSSAMQSAIEKLKDPSSAAVVGGQQAGLLTGPLYT IHKIISIIVLAKQQEKELQVPVIPIFWVAGEDHDLDEINFVHTSEENGPVKKKLPQSY WKKSSAASTSLDQEKCAAWIDDVFAAFEETDHTNTLLDNVKRCLRESVTFTDFFELLI ADLFQEEGLVLLNSGDPGIKKLETAMFQKILRENDELARAVSDQQAFMRQAGYKPIIE SGKEQANLFYEYEDERFLIEKDNGRFVIKELDLGWTRDELHTHMEEHPERFSNNVVTR PLMQEFLIPTLAFIAGPGEINYWGELKQAFAVMGFKMPPVMPRLNITILERHIEKKLA ERNISLQDAIERGTENQRETYFERQIPEEFTAVMDQAKSQIEAIHKTVRQEALKVDQS LEPLLLKNAAFIQDQLQFLERTVMKRIEEKEGYVLKDYERIQNSIKPLLAPQERIWNI MYYLNRYGPKFFTTFKNLPFSFQNQHQVVKL*" /label="bshC CDS" gene 1459571..1461190 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /label="bshC gene" downshifts 1461162 /Source="Nicolas_upshifts" /id="D859" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="3.87099" /MaxDrop="3.76832" /score="34.9463932" /energy="-8.3" /TU="U1262" /idTUdmin="U1262" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 1461224..1461227 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1461242..1461315 /Source="Nicolas_S_feature" /locus_tag="new_1580047_1580120" /HighExp="M9-stat, T5.0H, T3.0H, Lbstat, Lbtran, T2.30H, T1.30H, M0t90, T1.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="SigA" /TUlongPSig=1 /label="S554" promotor_-10 1461242..1461261 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1461242 /Source="Nicolas_upshifts" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1461299) /Source="Nicolas_upshifts" /id="D860" /incds=0 /nref=17 /ntot=137 /MaxReadThrough="3.30554" /MaxDrop="4.47473" /score="-9.92306593" /energy="-12" /TU="NA" /idTUdmin="U1264" /TUdmin=1149 /isTUend="FALSE" /label="downshifts" CDS 1461316..1461747 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /function="16.13: Shape" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10572301, 15939023, 16511046, 24659771, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of RsmH and transcriptional regulator" /protein_id="NP_389396.1" /db_xref="EnsemblGenomes-Gn:BSU15130" /db_xref="EnsemblGenomes-Tr:CAB13386" /db_xref="GOA:P55343" /db_xref="InterPro:IPR003444" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR020603" /db_xref="InterPro:IPR035642" /db_xref="InterPro:IPR035644" /db_xref="SubtiList:BG11425" /db_xref="UniProtKB/Swiss-Prot:P55343" /translation="MFMGEYQHTIDAKGRMIVPAKFREGLGEQFVLTRGLDQCLFGYP MHEWKQIEEKLKALPLTKKDARAFTRFFFSGATECELDKQGRVNIASSLLNYAKLEKE CVVIGVSNRIELWSKVIWEQYTEEQEDSFAEIAENMIGFDI*" /label="mraZ CDS" gene 1461316..1461747 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /label="mraZ gene" CDS 1461817..1462752 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /EC_number="2.1.1.199" /function="16.6: Maintain" /function="16.13: Shape" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9294438, 9721276, 10572301, 16849811, 19965768, 20924196, 22561317, 27711192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m4C1402 methyltransferase" /protein_id="NP_389397.1" /db_xref="EnsemblGenomes-Gn:BSU15140" /db_xref="EnsemblGenomes-Tr:CAB13387" /db_xref="GOA:Q07876" /db_xref="InterPro:IPR002903" /db_xref="InterPro:IPR023397" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10219" /db_xref="UniProtKB/Swiss-Prot:Q07876" /translation="MFQHKTVLLRETVDGLNIKPDGTYVDCTLGGAGHSTYLLQQLSE KGRLIAFDQDDTALQHAKEVLSDYKGQLILIKSNFRYLKEYLNEQGVTEVDGILFDLG VSSPQLDTPERGFSYHHDAPLDMRMDQSATLSAKEVVNEWRYEDLVRIFFKYGEEKFS KQIARKIEEARMKSPIQTTGQLVDLIKDAIPAPARRSGGHPAKRVFQAIRIAVNDELR VFEEALEQAIEVLKPGGRVSVITFHSLEDRICKTTFKEKSSLPELPPGLPVIPEEFEP ELKLITRKPITASQEELEENNRARSAKLRIAEKRK*" /label="rsmH CDS" gene 1461817..1462752 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /label="rsmH gene" S_feature complement(1462419..1463871) /Source="Nicolas_S_feature" /locus_tag="new_1581224_1582676_c" /HighExp="Salt, Sw, B60, Etha, M9-stat, Gly, C30, LPhT, BC, B36" /AntisenseName="ftsL" /AntisenseCor="-0.195961042435877" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S555" CDS 1462792..1463145 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein" /protein_id="NP_389398.1" /db_xref="EnsemblGenomes-Gn:BSU15150" /db_xref="EnsemblGenomes-Tr:CAB13388" /db_xref="GOA:Q07867" /db_xref="InterPro:IPR011922" /db_xref="SubtiList:BG10220" /db_xref="UniProtKB/Swiss-Prot:Q07867" /translation="MSNLAYQPEKQQRHAISPEKKVIVKKRASITLGEKVLLVLFAAA VLSVSLLIVSKAYAAYQTNIEVQKLEEQISSENKQIGDLEKSVADLSKPQRIMDIAKK NGLNLKDKKVKNIQE*" /label="ftsL CDS" gene 1462792..1463145 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /label="ftsL gene" CDS 1463142..1465292 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8636036, 10411726, 12682299, 14731276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636036, 10411726, 12682299, 14731276; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2B" /protein_id="NP_389399.2" /db_xref="EnsemblGenomes-Gn:BSU15160" /db_xref="EnsemblGenomes-Tr:CAB13389" /db_xref="GOA:Q07868" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10221" /db_xref="UniProtKB/Swiss-Prot:Q07868" /translation="MIQMPKKNKFMNRGAAILSICFALFFFVILGRMAYIQITGKANG EVLATKATEQHEKKRTIEASRGSILDRKGKVIAEDTATYKLIAILDKKMTTDVKHPQH VVNKEKTAEALSKVINLDKADILDILNKDAKQVEFGSAGRDITYSQKQKIEKMKLPGI SFLRDTKRYYPNGVFASNLIGYAEVDEETNEISGAMGLEKVLDKYLKERDGYVTYESD KSGWELPNSKNKITAPKNGDNVYLTIDQKIQTFLEDSMTKVAQKYNPKKIMAAVVDPK TGKVLAMGQRPSFDPNKRDVTNYYNDLISYAYEPGSTMKIFTLAAAMQENVFNANEKY KSGTFEVGGAPVKDHNNGVGWGPTTYHDGVLRSSNVAFAKLAKEKLGYDRLNQYLHKF NFYQKTGIDLPGEVSSKINFKYEFDKASTAYGQASAVTPIQQIQAATAIANDGKMMKP YVIDHIVDPDKDKTIYQNKPESAGTPISASTAKKVRDILGEVVTSKIGTGQAYKIEGF DVAGKTGTAQIAGKGGYLDGTDNYIFSFMGMAPKDDPELLIYVAVQQPQLKAGQSSSD PVSEIFNPTMKNSLHYLNIEPTEKSDSDKEETKAQTMPDLTDQTVAAAQKKAKEENLT PIVIGSDVAVKEQYPKADEEVLTNQKVFLKTGGKIKMPDMTGWSRREVLQYGELAGIH IEVSGQGYAVSQSVKKDKEIKDKTVIKVKFKNPD*" /label="pbpB CDS" gene 1463142..1465292 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /label="pbpB gene" promotor_-10 complement(1463852..1463870) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1463871) /Source="Nicolas_upshifts" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1463885..1463891) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1465275 /Source="Nicolas_upshifts" /id="D861" /incds=0 /nref=237 /ntot=257 /MaxReadThrough="1.141" /MaxDrop="6.28059" /score="3.41058446" /energy="-7.4" /TU="NA" /idTUdmin="U1263" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1465347..1465352 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-35" promotor_-10 1465368..1465386 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-10" upshifts 1465368 /Source="Nicolas_upshifts" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="upshifts" CDS 1465409..1467349 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8244929, 8289242, 9006059, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8244929, 8289242, 9006059, 28383125; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transpeptidase penicillin-binding protein" /protein_id="NP_389400.2" /db_xref="EnsemblGenomes-Gn:BSU15170" /db_xref="EnsemblGenomes-Tr:CAB13390" /db_xref="GOA:Q03524" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR011927" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10222" /db_xref="UniProtKB/Swiss-Prot:Q03524" /translation="MRVSNVTVRKRLLFVLLFGVIVFLIIDTRLGYVQFVMGEKLTSL AKDSWSRNLPFEPERGEILDRNGVKLATNKSAPTVFVVPRQVQNPMKTSKQLAAVLNM SEEKVYKHVTKKASIEKITPEGRKISNEKAKEIKALDLKGVYVAEDSIRHYPFGSFLS HVLGFAGIDNQGLLGLEAYYDDDLKGEKGSVKFYTDAKGKKMPDEADDYTPPKDGLDM KLTVDSKVQTIMERELDNAEAKYHPDGMIAVAMNPKNGEILGMSSRPDFDPADYQSVD PSVYNRNLPVWSTYEPGSTFKIITLAAALEEQKVNLKRDQFYDKGHAEVDGARLRCWK RGGHGLQTYLEVVQNSCNPGFVELGERLGKEKLFKYIKDFGFGQKTGIDLQGEGTGIL FPLERVGPVEQATTAFGQGVSVTPIQQVAAVSAAVNGGTLYTPYIAKEWIDPVTKKTV KKQSPIAKKQVISEETSKQIRYALESVVAEGTGRNAFVEGYRVGGKTGTAQKVKDGKY LENNHIVSFIGFAPADDPSLVVYVAVDNPKGTIQFGGTVAAPIVGNIMRDSLPELGVK PRKNQIEKKYQWNDTKTIEVPNVVGMSVSDLESLLVNLNVDASGKGSKIVKQSPAAGT KVKEGSKIRVYLTEEDEKEAAD*" /label="spoVD CDS" gene 1465409..1467349 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /label="spoVD gene" promotor_-35 1467145..1467151 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-35" promotor_-10 1467166..1467174 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-10" upshifts 1467172 /Source="Nicolas_upshifts" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="upshifts" downshifts 1467322 /Source="Nicolas_upshifts" /id="D862" /incds=0 /nref=19 /ntot=91 /MaxReadThrough="4.23549" /MaxDrop="4.37308" /score="-3.90592085" /energy="-13.6" /TU="U1265,U1266" /idTUdmin="U1265" /TUdmin="-91" /isTUend="FALSE" /label="downshifts" S_feature 1467367..1467434 /Source="Nicolas_S_feature" /locus_tag="new_1586172_1586239" /HighExp="C30, G180, G135, ferm, MG 15, G150, MG 45, MG-0.1, MG 10, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S556" promotor_-35 1467404..1467408 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1467424..1467443 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" S_feature 1467436..1467524 /Source="Nicolas_S_feature" /locus_tag="new_1586241_1586329" /HighExp="G180, G150, LBGexp, Paraq, G135, Oxctl, C30, dia0, Cold, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S557" upshifts 1467436 /Source="Nicolas_upshifts" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" CDS 1467525..1469009 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /EC_number="6.3.2.13" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8436954, 10520745, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase" /protein_id="NP_389401.1" /db_xref="EnsemblGenomes-Gn:BSU15180" /db_xref="EnsemblGenomes-Tr:CAB13391" /db_xref="GOA:Q03523" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005761" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10223" /db_xref="UniProtKB/Swiss-Prot:Q03523" /translation="MKLTKLLTYLTTEPSVNDSQDPEITSIEMDSREVKKGSLFVCVK GYTVDGHDFAQKAVENGAAAIVAEREVDVNVPVIIVRQSLRALSVLSDAFYGQPTKKL QLIGITGTNGKTSTTHMVDEILKKAGKRTGLIGTMYMKIGDETLPVKNTTPESVTLQK TFKKMNDKHVDTAIMEVSSHALSLGRVHGCDYDIAVFTNLTQDHLDYHKTMDEYRHAK SLLFSQLGGAFNHEHPKRAVLNADDEASAYFEKVTAAHISTYGIKNDADVMAKNISIT AQGTSFDLVTNKGTKHITMSLVGQFNVYNVLAAVATCIAAGIPFEIITEAVEELHGVR GRFELVNQQQEFPVIVDYAHTPDSLENVLETCRDMTEGKLFVVVGCGGDRDKTKRPKM AKIAVELADEPIFTSDNPRSEDPRAILRDMEAGVENAYYHSIANREQAIFFAIANAKK GDVVLIAGKGHETYQQIGNETFDFDDAEVAARAIVELNKNKTNS*" /label="murE CDS" gene 1467525..1469009 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /label="murE gene" S_feature 1469010..1469120 /Source="Nicolas_S_feature" /locus_tag="new_1587815_1587925" /HighExp="G180, G135, G150, C30, Oxctl, dia0, LBGexp, MG 25, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S558" CDS 1469121..1470095 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /EC_number="2.7.8.13" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phospho-N-acetylmuramoyl-pentapeptide undecaprenyl phosphate (C55P) transferase" /protein_id="NP_389402.2" /db_xref="EnsemblGenomes-Gn:BSU15190" /db_xref="EnsemblGenomes-Tr:CAB13392" /db_xref="GOA:Q03521" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR003524" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG10224" /db_xref="UniProtKB/Swiss-Prot:Q03521" /translation="MLEQVILFTILMGFLISVLLSPILIPFLRRLKFGQSIREEGPKS HQKKSGTPTMGGVMIILSIIVTTIVMTQKFSEISPEMVLLLFVTLGYGLLGFLDDYIK VVMKRNLGLTSKQKLIGQIIIAVVFYAVYHYYNFATDIRIPGTDLSFDLGWAYFILVL FMLVGGSNAVNLTDGLDGLLSGTAAIAFGAFAILAWNQSQYDVAIFSVAVVGAVLGFL VFNAHPAKVFMGDTGSLALGGAIVTIAILTKLEILLVIIGGVFVIETLSVILQVISFK TTGKRIFKMSPLHHHYELVGWSEWRVVVTFWAAGLLLAVLGIYIEVWL*" /label="mraY CDS" gene 1469121..1470095 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /label="mraY gene" CDS 1470096..1471451 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /EC_number="6.3.2.9" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1765076, 9218784, 10966819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate ligase" /protein_id="NP_389403.1" /db_xref="EnsemblGenomes-Gn:BSU15200" /db_xref="EnsemblGenomes-Tr:CAB13393" /db_xref="GOA:Q03522" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005762" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10225" /db_xref="UniProtKB/Swiss-Prot:Q03522" /translation="MENDQFLQKQHFLILGLAKSGYAAASILHEKGIYVAVNDQKPFE ENEPAQKLSEKGIEVVCGEHPVSLFDQHQITILIKNPGIPYENIMVQEAEKRGIPVWT EIELAYYLTSAKFIGITGSNGKTTTTTLIYEMLKADSQKALIAGNIGTVASEVAYHAD GDEWIVTELSSFQLMGTHAFRPEISLILNVFDAHLDYHHTRENYEKAKQKVYLHQTAS DKAIVNQDDETVVRLAEAGKAEIVPFSVSKTLEQGAYVKDSMIMFNGEAILPLEEVVL PGAHNLENILAAIAVVKTAGASNEAVKKVLTSFTGVKHRLQYVTTVNGRKFYNDSKAT NILATSKALSAFDKPVILLAGGLDRGNGFDDLKPYMKHVKAVLTFGQTAPKLEKLGNE LGIQHVKRVDNVEQAVSAAFALSNEGDVILLSPACASWDQFKTFEERGDMFIDAVHML K*" /label="murD CDS" gene 1470096..1471451 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /label="murD gene" promotor_-35 1471275..1471280 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-35" promotor_-10 1471296..1471314 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-10" upshifts 1471306 /Source="Nicolas_upshifts" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="upshifts" CDS 1471512..1472612 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:2509435, 9622350, 15849754, 16484183, 16850406, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509435, 9622350, 15849754, 16484183, 16850406, 27312048; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="factor for spore cortex peptidoglycan synthesis (stage V sporulation)" /protein_id="NP_389404.1" /db_xref="EnsemblGenomes-Gn:BSU15210" /db_xref="EnsemblGenomes-Tr:CAB13394" /db_xref="GOA:P07373" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR013437" /db_xref="InterPro:IPR013438" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10226" /db_xref="UniProtKB/Swiss-Prot:P07373" /translation="MTTKKTSPDLLLVIITLLLLTIGLIMVYSASAVWADYKFDDSFF FAKRQLLFAGIGVIAMFFIMNVDYWTWRTWSKLLMVICFFLLVLVLIPGVGMVRNGSR SWIGVGAFSIQPSEFMKLAMIAFLAKFLSEKQKNITSFRRGFVPALGIVFSAFLIIMC QPDLGTGTVMVGTCIVMIFVAGARIAHFVFLGLIGLSGFVGLVLSAPYRIKRITSYLN PWEDPLGSGFQIIQSLYAVGPGGLFGMGLGQSRQKFFYLPEPQTDFIFAILSEELGFI GGTLILLLFSVLLWRGIRIALGAPDLYGSFVAVGIISMIAIQVMINIGVVTGLIPVTG ITLPFLSYGGSSLTLMLMAVGVLLNVSRYSRY*" /label="spoVE CDS" gene 1471512..1472612 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /label="spoVE gene" S_feature 1472613..1472734 /Source="Nicolas_S_feature" /locus_tag="new_1591418_1591539" /HighExp="G180, C30, G135, G150, Oxctl, Paraq, LBGexp, dia0, S3, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-" /TUshortPSig="0.569, 1, 0.436" /TUlongSig="NA" /TUlongPSig="NA" /label="S559" CDS 1472735..1473826 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /EC_number="2.4.1.227" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9244290, 11042447, 12538870, 12682299, 12813070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9244290, 11042447, 12538870, 12682299, 12813070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine-N-acetylmuramyl- (pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase" /protein_id="NP_389405.2" /db_xref="EnsemblGenomes-Gn:BSU15220" /db_xref="EnsemblGenomes-Tr:CAB13395" /db_xref="GOA:P37585" /db_xref="InterPro:IPR004276" /db_xref="InterPro:IPR006009" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10227" /db_xref="UniProtKB/Swiss-Prot:P37585" /translation="MRIAISGGGTGGHIYPALAFIKEVQRRHPNVEFLYIGTENGLEK KIVERENIPFRSIEITGFKRKLSFENVKTVMRFLKGVKKSKSYLAEFKPDAVIGTGGY VCGPVVYAAAKMGIPTIVHEQNSLPGITNKFLSKYVNKVAICFEEAKSHFPSEKVVFT GNPRASEVVSIKTGRSLAEFGLSEDKKTVLIFGGSRGAAPINRAVIDMQDVLKTRDYQ VLYITGEVHYEKVMNELKSKGAADNMVTKPFLHQMPEYLKAIDVIVARAGATTIAEIT ALGIPSVLIPSPYVTANHQEVNARSLGQHDAAIVLKETELSGEKLIEALDRIVLNEQT LKEMSERTKSLGVPDAAARLYSVLEELKK*" /label="murG CDS" gene 1472735..1473826 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /label="murG gene" promotor_-35 1473215..1473224 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1473237..1473252 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1473242 /Source="Nicolas_upshifts" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" promotor_no_box 1473248..1473348 /Source="Nicolas_upshift_promotors" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1473308 /Source="Nicolas_upshifts" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1473858..1474769 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /EC_number="1.3.1.98" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11327854, 12682299, 16484183, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylenolpyruvoylglucosamine reductase" /protein_id="NP_389406.1" /db_xref="EnsemblGenomes-Gn:BSU15230" /db_xref="EnsemblGenomes-Tr:CAB13396" /db_xref="GOA:P18579" /db_xref="InterPro:IPR003170" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR011601" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036635" /db_xref="SubtiList:BG10228" /db_xref="UniProtKB/Swiss-Prot:P18579" /translation="MEKVIQELKEREVGKVLANEPLANHTTMKIGGPADVLVIPSSVD AVKDIMDVIKKYDVKWTVIGRGSNLLVLDEGIRGVVIKLGAGLDHLELEGEQVTVGGG YSVVRLATSLSKKGLSGLEFAAGIPGSVGGAVYMNAGAHGSDMSEILVKAHILFEDGT IEWLTNEQMDFSYRTSVLQKKRPGVCLEAVLQLEQKDKESIVQQMQSNKDYRKNTQPY SSPCAGSIFRNPLPNHAGNLVEKAGLKGYQIGGAKISEMHGNFIVNAGGASAKDVLDL IDHVKKTIREKYEIDMHTEVEIIGGNR*" /label="murB CDS" gene 1473858..1474769 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /label="murB gene" downshifts 1474787 /Source="Nicolas_upshifts" /id="D863" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="5.78428" /MaxDrop="2.8642" /score="-7.67573434" /energy="-7.4" /TU="U1267,U1268,U1269,U1270" /idTUdmin="U1266" /TUdmin=1809 /isTUend="FALSE" /label="downshifts" CDS 1474899..1475690 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389407.1" /db_xref="EnsemblGenomes-Gn:BSU15240" /db_xref="EnsemblGenomes-Tr:CAB13397" /db_xref="GOA:P16655" /db_xref="InterPro:IPR005548" /db_xref="InterPro:IPR013685" /db_xref="InterPro:IPR026580" /db_xref="InterPro:IPR034746" /db_xref="SubtiList:BG10229" /db_xref="UniProtKB/Swiss-Prot:P16655" /translation="MNPGQDREKIVNIEERIPKIKEQRKQKANRRLISFIMLFFIMVL IIVYLQTPISKVSTISVTGNENVSKKEIIDLSDINSGDTEFWSLDKQKTEKKIQQNKL VKKAEISKSLPNKINIAIEEYKAIAYLEKDDVYYEVLENGSVLPNEVTPDDAGPILVN WTNAKKRSQMAKQLDALSNSLKQSISEIYYTPVKMDENRIKLYMNDGYVVTASIKTFA DRMKTYPSIISQLSSNKKGIIHLEVATYFEEFGKNDKAAKKEDEN*" /label="divIB CDS" gene 1474899..1475690 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /label="divIB gene" CDS 1475687..1476382 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389408.2" /db_xref="EnsemblGenomes-Gn:BSU15250" /db_xref="EnsemblGenomes-Tr:CAB13398" /db_xref="GOA:C0SPA3" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11490" /db_xref="UniProtKB/Swiss-Prot:C0SPA3" /translation="MRGKSAVLLSLIMLIAGFLISFSFQMTKENNKSAAETEEWKKEY ALRDELLKQEKENKKFEKELYQKQNKVRQAENKLKKEKSEYYNVLEDTEKYRMYIGEV GVQGEGVEVTLEDASYIPEGENVNSYIVHESHIFQVVNELYISGAAAVAVNGQRLTHD SYIKCNGPVVTVDGVQHPAPFTVSAIGDPDVLLPSLNIAGGLIDQLSMDHISVSAEKE KNVQMKPILKTKE*" /label="ylxW CDS" gene 1475687..1476382 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /label="ylxW gene" CDS 1476405..1477112 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183, 18179421" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389409.2" /db_xref="EnsemblGenomes-Gn:BSU15260" /db_xref="EnsemblGenomes-Tr:CAB13399" /db_xref="GOA:Q45544" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11489" /db_xref="UniProtKB/Swiss-Prot:Q45544" /translation="MKIKRSFISISVLMVIFGLMISVQFNSLKHPKVRDTRDMWDIRE ELTSEQKKQEKLLAEINKYDKLLNSYSQTKEMTKETALNNTLQSLKKTAGMTDITGSG IVITISPLFSESLTGEPIENPPPDLLKKLINELNSYGAEHISINERRVVNHTVIRDIN GTTKIDGYALDDYPLTVKVLAKDPDMLHSRVKGSGLEDLFASENLALKAGKSESKLTL KAYDRPLDVQQLKLLKD*" /label="ylxX CDS" gene 1476405..1477112 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /label="ylxX gene" CDS 1477130..1477495 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1569582, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (small basic protein)" /protein_id="NP_389410.1" /db_xref="EnsemblGenomes-Gn:BSU15270" /db_xref="EnsemblGenomes-Tr:CAB13400" /db_xref="GOA:P28265" /db_xref="InterPro:IPR009709" /db_xref="SubtiList:BG10230" /db_xref="UniProtKB/Swiss-Prot:P28265" /translation="MWLPVLGLVLGIAIGLMTNLTIPSEYSNYLSLAVLAALDTLIGG IRAHLQGTYDEMVFVSGFFFNIILAISLAFLGVHLGVDLYLAGIFAFGVRLFQNIAVI RRNLLTKWTLSKKNKKNVI*" /label="sbp CDS" gene 1477130..1477495 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /label="sbp gene" promotor_-35 1477347..1477350 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1477366..1477385 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1477382 /Source="Nicolas_upshifts" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" S_feature 1477496..1477668 /Source="Nicolas_S_feature" /locus_tag="new_1596301_1596473" /HighExp="T3.0H, T2.30H, S2, T3.30H, Lbtran, T4.0H, T5.0H, T1.30H, S1, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigWXY, SigA" /TUshortPSig="0.989, 0.0739, 1, 1" /TUlongSig="SigEF, Sig-" /TUlongPSig="0.569, 0.436" /label="S560" CDS 1477669..1478991 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein essential for Z-ring assembly" /protein_id="NP_389411.2" /db_xref="EnsemblGenomes-Gn:BSU15280" /db_xref="EnsemblGenomes-Tr:CAB13401" /db_xref="GOA:P28264" /db_xref="InterPro:IPR003494" /db_xref="InterPro:IPR020823" /db_xref="SubtiList:BG10231" /db_xref="UniProtKB/Swiss-Prot:P28264" /translation="MNNNELYVSLDIGTSNTKVIVGEMTDDSLNIIGVGNVPSEGLKK GSIVDIDETVHSIRKAFDQAERMVGFPLRKAIVGVNGNYINIQDTNGVVAVSSENKEI QVEDVRRVMEAAQVVSVPHEQLIVDVIPKQFIVDGRDEITDPKKMLGVRLEVEGTLIT GSKTILHNLLRCVERAGIEITDICLQPLAAGSAALSKDEKNLGVALIDIGGGSTTIAV FQNGHLTSTRVIPLGGENITKDISIGLRTSTEEAERVKKQLGHAYYDEASEDEIFEVT VIGTNQKQTFTQQEAANIIEARVEEILEIVSEELRSMGITDLPGGFVLTGGQAAMPGV MSLAQDVLQNNVRVASPNYIGVRDPQYMTGVGLIQFACRNARIQGRKIGFKMPEEAIQ EIAVSSSEEQEQHHHQNEVQQRPKGKQKTQAEHNKQSKMKKLLSMFWE*" /label="ftsA CDS" gene 1477669..1478991 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /label="ftsA gene" upshifts complement(1477876) /Source="Nicolas_upshifts" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1477880..1477884) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1477899..1477903) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1479027..1480175 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389412.2" /db_xref="EnsemblGenomes-Gn:BSU15290" /db_xref="EnsemblGenomes-Tr:CAB13402" /db_xref="GOA:P17865" /db_xref="InterPro:IPR000158" /db_xref="InterPro:IPR003008" /db_xref="InterPro:IPR008280" /db_xref="InterPro:IPR018316" /db_xref="InterPro:IPR020805" /db_xref="InterPro:IPR024757" /db_xref="InterPro:IPR036525" /db_xref="InterPro:IPR037103" /db_xref="PDB:2RHH" /db_xref="PDB:2RHJ" /db_xref="PDB:2RHL" /db_xref="PDB:2RHO" /db_xref="PDB:2VAM" /db_xref="PDB:2VXY" /db_xref="PDB:4U39" /db_xref="SubtiList:BG10232" /db_xref="UniProtKB/Swiss-Prot:P17865" /translation="MLEFETNIDGLASIKVIGVGGGGNNAVNRMIENEVQGVEYIAVN TDAQALNLSKAEVKMQIGAKLTRGLGAGANPEVGKKAAEESKEQIEEALKGADMVFVT AGMGGGTGTGAAPVIAQIAKDLGALTVGVVTRPFTFEGRKRQLQAAGGISAMKEAVDT LIVIPNDRILEIVDKNTPMLEAFREADNVLRQGVQGISDLIATPGLINLDFADVKTIM SNKGSALMGIGIATGENRAAEAAKKAISSPLLEAAIDGAQGVLMNITGGTNLSLYEVQ EAADIVASASDQDVNMIFGSVINENLKDEIVVTVIATGFIEQEKDVTKPQRPSLNQSI KTHNQSVPKREPKREEPQQQNTVSRHTSQPADDTLDIPTFLRNRNKRG*" /label="ftsZ CDS" gene 1479027..1480175 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /label="ftsZ gene" downshifts 1480149 /Source="Nicolas_upshifts" /id="D864" /incds=0 /nref=226 /ntot=389 /MaxReadThrough="2.85051" /MaxDrop="7.70428" /score="34.7919519" /energy="-13.7" /TU="U1267,U1271" /idTUdmin="U1269" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" SCAR join(1480270,1480277) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs20" N_region 1480271..1480276 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs20" S_feature <1480277..1480322 /Source="Nicolas_S_feature" /locus_tag="new_1606413_1606501" /HighExp="LoTm, S7, S8, BT, S6, S4, G/S, S3, S2, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S565" promotor_-35 1480287..1480294 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1480307..1480326 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1480324 /Source="Nicolas_upshifts" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" CDS 1480381..1481175 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683, 18083814; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389417.2" /db_xref="EnsemblGenomes-Gn:BSU15340" /db_xref="EnsemblGenomes-Tr:CAB13408" /db_xref="GOA:O31723" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13370" /db_xref="UniProtKB/Swiss-Prot:O31723" /translation="MILQLDNVSLKRNGKWILKDIHWKVEEKENWVLYGLNGAGKTAL LNMLCSYYFPTSGEMQVLGHEFGKTELGEKLRRKIGLVSAALQQKLYPADSAFEIALS GAYASIGLYETPSKETREKAIGLLEDLGAIEYADRRYETLSQGEKQRALIARALMADP ELLILDEPVTGLDFIAREKLLDTITYIANKENAPSILYVTHHAEEILPVFDKALLLKQ GEVFGSGEIKEMLTDQILSAFFDTPIHVLWNQDRPFLTRAEPITNA*" /label="ylmA CDS" gene 1480381..1481175 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /label="ylmA gene" promotor_-35 1481093..1481096 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-35" promotor_-10 1481111..1481130 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-10" upshifts 1481119 /Source="Nicolas_upshifts" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="upshifts" misc_RNA 1481188..1481289 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswE RNA" gene 1481188..1481289 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /label="tswE gene" downshifts 1481276 /Source="Nicolas_upshifts" /id="D867" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="5.58534" /MaxDrop="4.3688" /score="-2.39598083" /energy="-7.1" /TU="U1278,U1279" /idTUdmin="U1274" /TUdmin=971 /isTUend="FALSE" /label="downshifts" CDS 1481377..1482657 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /EC_number="3.5.1.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17618314" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17618314; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-4-amino-5-aminomethyl-2- methylpyrimidinedeformylase" /protein_id="NP_389418.2" /db_xref="EnsemblGenomes-Gn:BSU15350" /db_xref="EnsemblGenomes-Tr:CAB13409" /db_xref="GOA:O31724" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13371" /db_xref="UniProtKB/Swiss-Prot:O31724" /translation="MDQQIYSLQKKVEEHKEELIQLAKTLISYQTPAPPARNTEGIQS WIAGYLNELGFSIDKWDVYPGDPNVVGKLKGTDSADYYSLIINGHVDVAEVKEDEEWK HDPFHPIEKNGLLIGRGASDMKGGMACVLFAVKLIREASIELPGDLILQSVIGEEVGE AGTLECCKRGYHADFAIVADTSDMHIQGQGGVITGWIEIKSSQTFHDGTRRNMIHAGG GTFGASAIEKMAKIIAGLGELERHWSIMKSYPGFKPGTNTINPAVIEGGRHAAFIADE CRLWITVHFYPNETHDQVAAEIEDYVNRLSDSDIWLRENRPVFKWGGSSMIEDRGEIF PALEVDPGHPGVLALTASHQKVKRECPIIDVSQSVTDGGWLYDAGIPCVIYGPGDLHN AHSVNEKVSIEQLVEYTKIILDFIISWCSRKKEQ*" /label="thiQ CDS" gene 1481377..1482657 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /label="thiQ gene" misc_feature complement(1482598..1482614) /Source="Nicolas_upshift_promotors" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1482603) /Source="Nicolas_upshifts" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1482678..1482683 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-35" promotor_-10 1482699..1482717 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-10" upshifts 1482703 /Source="Nicolas_upshifts" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="upshifts" CDS 1482740..1482985 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /experiment="publication(s) with functional evidences, PMID:12429060, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12429060, 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="essential sporulation protein" /protein_id="NP_389419.1" /db_xref="EnsemblGenomes-Gn:BSU15360" /db_xref="EnsemblGenomes-Tr:CAB13410" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13372" /db_xref="UniProtKB/Swiss-Prot:O31725" /translation="MISISEFQVKDVVNVSNGKKLGSIGDIDINVTTGKIQAIILGGN GKVLGFFGKEEELVIPWRNIVKIGEDVILVRLSEPHA*" /label="ylmC CDS" gene 1482740..1482985 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /label="ylmC gene" promotor_-35 1482901..1482909 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1482920..1482938 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1482928 /Source="Nicolas_upshifts" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" S_feature 1482986..1483096 /Source="Nicolas_S_feature" /locus_tag="new_1609165_1609275" /HighExp="T3.0H, S2, S1, T4.0H, T3.30H, T5.0H, T2.0H, BC, Gly, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34150000000000003" /TUshortSig="SigH, SigEF, SigA, SigA" /TUshortPSig="1, 0.998, 0.976, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S566" misc_feature 1483088..1483107 /Source="Nicolas_upshift_promotors" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1483098 /Source="Nicolas_upshifts" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" CDS 1483148..1483984 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16498617, 19737354; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved protein with laccase domain" /protein_id="NP_389420.1" /db_xref="EnsemblGenomes-Gn:BSU15370" /db_xref="EnsemblGenomes-Tr:CAB13411" /db_xref="GOA:O31726" /db_xref="InterPro:IPR003730" /db_xref="InterPro:IPR011324" /db_xref="SubtiList:BG13373" /db_xref="UniProtKB/Swiss-Prot:O31726" /translation="MNTYHPFSLTTPSTLMIQDWAQTNQNNKEVIAGFTTKNGGVSQK PFESLNTGLHVHDKDADVVKNREYIADMFNTDLQSWVFADQTHDNRVQKVTQRDRGKG AREYHTALKATDGIYTNEKNVFLALCFADCVPLFFYDPVKSLVGVAHAGWKGTVKQIG REMVKQWTEKEGSNPSDIYAVIGPSISGACYTVDDRVMDAVRALPVSADLAANQTAKA QYQLDLKELNRLILMDSGLASEQISVSGLCTESEPSLFYSHRRDQGKTGRMMSFIGMK EA*" /label="ylmD CDS" gene 1483148..1483984 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /label="ylmD gene" CDS 1483991..1484683 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14526035, 24097949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PLP-containing enzyme" /protein_id="NP_389421.1" /db_xref="EnsemblGenomes-Gn:BSU15380" /db_xref="EnsemblGenomes-Tr:CAB13412" /db_xref="GOA:O31727" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR011078" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG13374" /db_xref="UniProtKB/Swiss-Prot:O31727" /translation="MRVVDNLRHINERINEACNRSGRSSDEVTVIAVTKYVSPERAQE AVDAGITCLGENRDAELLRKQELMKGNPEWHFIGSLQSRKAKSVVNSVSYIHSLDRLS LAKEIEKRAEGTVRCFVQVNTSLEPSKHGMKKEEVIPFIQELSGFEHILVAGLMTMAP LTDDQDQIRSCFRSLRELRDQVQKLNQPNAPCTELSMGMSNDFEIAIEEGATYIRIGS SLVGNETGGVQQ*" /label="ylmE CDS" gene 1483991..1484683 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /label="ylmE gene" CDS 1484680..1485135 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14526035, 16420366, 16796675, 18782755, 22912848, 24218584" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526035, 16420366, 16796675, 18782755, 22912848, 24218584; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division machinery factor" /protein_id="NP_389422.3" /db_xref="EnsemblGenomes-Gn:BSU15390" /db_xref="EnsemblGenomes-Tr:CAB13413" /db_xref="GOA:O31728" /db_xref="InterPro:IPR007561" /db_xref="InterPro:IPR023052" /db_xref="PDB:3ZIH" /db_xref="PDB:3ZII" /db_xref="SubtiList:BG13375" /db_xref="UniProtKB/Swiss-Prot:O31728" /translation="MSMKNKLKNFFSMEDEEYEYEYIETERESHEEHEQKEKPAYNGN KPAGKQNVVSLQSVQKSSKVVLSEPRVYAEAQEIADHLKNRRAVVVNLQRIQHDQAKR IVDFLSGTVYAIGGDIQRIGSDIFLCTPDNVDVSGTISELISEDEHQRW*" /label="sepF CDS" gene 1484680..1485135 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /label="sepF gene" CDS 1485142..1485414 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14526035, 19966467, 20359373; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, distribution of nucleoids and osmotic tolerance" /protein_id="NP_389423.1" /db_xref="EnsemblGenomes-Gn:BSU15400" /db_xref="EnsemblGenomes-Tr:CAB13414" /db_xref="GOA:O31729" /db_xref="InterPro:IPR003425" /db_xref="SubtiList:BG13376" /db_xref="UniProtKB/Swiss-Prot:O31729" /translation="MILYQVFSVLSLLITIYSFALIIYIFMSWVPSTRETAVGRFLAS ICEPYLEPFRKIIPPIAMLDISPIVAILVLRFATTGLWGLYRMIAF*" /label="ylmG CDS" gene 1485142..1485414 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /label="ylmG gene" downshifts 1485403 /Source="Nicolas_upshifts" /id="D868" /incds=0 /nref=16 /ntot=97 /MaxReadThrough="6.19839" /MaxDrop="4.93537" /score="-6.17078585" /energy="-15.2" /TU="U1278,U1281,U1282,U1283" /idTUdmin="U1281" /TUdmin="-1452" /isTUend="FALSE" /label="downshifts" CDS 1485475..1486248 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10093218, 14526035, 21141807; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, RNA-binding fold" /protein_id="NP_389424.1" /db_xref="EnsemblGenomes-Gn:BSU15410" /db_xref="EnsemblGenomes-Tr:CAB13415" /db_xref="GOA:P71020" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11856" /db_xref="UniProtKB/Swiss-Prot:P71020" /translation="MSDIYQHFRKDERAFIDQALEWKRIVQEQYRMKLTDFLDPREQV ILSAVTGQADVGLAFSGGYDRAERKRAILFPEYITPEESDFELQAFNVRYADKFVSVD HRSLLGALMGIGLKRQKFGDIVFSETAVQLIVSADTADFVAAQLTQAGKAAVSLEKID LSDLNIPAVDVEIRDDTVSSLRLDAVCASMSRQSRQKSQTLVKNGLVKVNWKVVEDPS YIVAEGDMLSIRGFGRCSLTKIEGKTKKDKWRVTFERQK*" /label="ylmH CDS" gene 1485475..1486248 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /label="ylmH gene" promotor_-35 1485964..1485971 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1485985..1486003 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1486008 /Source="Nicolas_upshifts" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" S_feature 1486249..1486341 /Source="Nicolas_S_feature" /locus_tag="new_1612428_1612520" /HighExp="C90, M0t90, C30, GM-0.1, Glucon, MG 5, GM 45, GM 5, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigH, SigEF, SigA" /TUshortPSig="0.973, 1, 1, 0.998, 0.989" /TUlongSig="SigA" /TUlongPSig="0.976" /label="S567" CDS 1486342..1486836 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389425.1" /db_xref="EnsemblGenomes-Gn:BSU15420" /db_xref="EnsemblGenomes-Tr:CAB13416" /db_xref="GOA:P71021" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR019933" /db_xref="PDB:2WUJ" /db_xref="PDB:2WUK" /db_xref="SubtiList:BG11835" /db_xref="UniProtKB/Swiss-Prot:P71021" /translation="MPLTPNDIHNKTFTKSFRGYDEDEVNEFLAQVRKDYEIVLRKKT ELEAKVNELDERIGHFANIEETLNKSILVAQEAAEDVKRNSQKEAKLIVREAEKNADR IINESLSKSRKIAMEIEELKKQSKVFRTRFQMLIEAQLDLLKNDDWDHLLEYEVDAVF EEKE*" /label="divIVA CDS" gene 1486342..1486836 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /label="divIVA gene" promotor_-35 1486849..1486856 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1486870..1486889 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1486877 /Source="Nicolas_upshifts" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1486899..1487125 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /product="T-box riboswitch specific of isoleucine tRNA" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /label="iswA RNA" gene 1486899..1487125 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /label="iswA gene" downshifts 1487092 /Source="Nicolas_upshifts" /id="D869" /incds=0 /nref=43 /ntot=100 /MaxReadThrough="7.76706" /MaxDrop="5.97038" /score="48.8352635" /energy="-19.4" /TU="U1278,U1282,U1283,U1284,U1285" /idTUdmin="U1281" /TUdmin=237 /isTUend="FALSE" /label="downshifts" CDS 1487178..1489943 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /EC_number="6.1.1.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16697013, 17043414, 17095543, 28139725; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucyl-tRNA synthetase" /protein_id="NP_389426.2" /db_xref="EnsemblGenomes-Gn:BSU15430" /db_xref="EnsemblGenomes-Tr:CAB13417" /db_xref="GOA:Q45477" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002301" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023585" /db_xref="InterPro:IPR033708" /db_xref="SubtiList:BG11792" /db_xref="UniProtKB/Swiss-Prot:Q45477" /translation="MDFKDTLLMPKTDFPMRGNLPNREPDIQKKWEEEDIYRLVQERT KDRPKFVLHDGPPYANGDIHMGHALNKILKDFIVRYKSMSGYNAPYVPGWDTHGLPIE TALTKNKKVNRKEMSVAEFRKLCEEYAWKQIEGQREQFKRLGVRGDWENPYVTLKPEY EAQQIRVFGEMAKRGYIYKGLKPVNWSPSSESALAEAEIEYQDKRSASIYVAFGVKDG KGVLENGERIIIWTTTPWTIPANLGISVHPDLEYSVIAVGEDRFVVASALVENVASAC GFDQYEVTRTVKGKDLENIIAEHPLYGRDSLVMLGEHVTTDAGTGCVHTAPGHGEDDF IIGQKYGLDVLCPVDEKGVMTSEAPGFEGMFYDDANKAITQQLDEKGALVKLEFITHS YPHDWRTKKPTIFRATAQWFASIKDFRSDLLDAIKETKWVPEWGEQRLHNMVRDRGDW CISRQRAWGVPIPVFYAENGEPVITDETIEHVSELFRQHGSNIWFEKEAKDLLPEGFT HPGSPNGTFTKEQDIMDVWFDSGSSHQAVLEERDDLVRPADLYLEGSDQYRGWFNSSL STAVAVTGKAPYKGVLSHGFALDGEGRKMSKSIGNVVVPAKVMKQLGADILRLWVSSV DYQADVRVSDAILKQVAEVYRKIRNTFRFLHGNLFDFDPKTNAVAVEDLREVDQYMLI KLNKLIDKVKKAYDEYEFAVVYHSIHNFCTIELSSFYLDFAKDIVYIEHADHPDRRSM QTVFYETLLALVKLSAPILPHTADELWSHLTFVEEQSVQLTDMPETITVPNSEATEEK FDRFMALRDDVLKALETARNEKIIGKSLEANLKLYPNKENKELLASIKENLSQLFIVS ELTISEENEAPNDAQSFATGKIAVEKAEGEMCERSRVISKDVGANPKYPTLSLRNAEI VEKYYQK*" /label="ileS CDS" gene 1487178..1489943 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /label="ileS gene" downshifts 1489934 /Source="Nicolas_upshifts" /id="D870" /incds=0 /nref=233 /ntot=261 /MaxReadThrough="2.6695" /MaxDrop="6.91924" /score="40.2175565" /energy="-13.9" /TU="NA" /idTUdmin="U1278" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(1489989) /Source="Nicolas_upshifts" /id="D871" /incds=0 /nref=6 /ntot=17 /MaxReadThrough="1.29709" /MaxDrop="3.66645" /score="13.8608728" /energy="-15.6" /TU="NA" /idTUdmin="U1275" /TUdmin="-12534" /isTUend="FALSE" /label="downshifts" promotor_-35 1490024..1490030 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-35" promotor_-10 1490045..1490056 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-10" upshifts 1490045 /Source="Nicolas_upshifts" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="upshifts" CDS 1490088..1490462 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15496987, 23123912, 23678950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15496987, 23123912, 23678950; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related RNA polymerase-binding factor" /protein_id="NP_389427.2" /db_xref="EnsemblGenomes-Gn:BSU15440" /db_xref="EnsemblGenomes-Tr:CAB13418" /db_xref="GOA:Q45478" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR016841" /db_xref="InterPro:IPR020458" /db_xref="SubtiList:BG11795" /db_xref="UniProtKB/Swiss-Prot:Q45478" /translation="MNDQLTAIYTELLLMKEELQSRLFEYSCFQVSTSPQAAINQKQK ATLIYHIKEELQDVLLALSKIENGTFGYCEETGAPIPLAKLAVLPTARTANDFLYSVQ FEKKTLPIWKSTDIEYGQALYE*" /label="ylyA CDS" gene 1490088..1490462 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /label="ylyA gene" promotor_-35 1490494..1490498 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" upshifts 1490513 /Source="Nicolas_upshifts" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="upshifts" promotor_-10 1490514..1490533 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" CDS 1490565..1491029 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /EC_number="3.4.23.36" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9880550, 9882689, 10497172, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880550, 9882689, 10497172, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="signal peptidase II" /protein_id="NP_389428.1" /db_xref="EnsemblGenomes-Gn:BSU15450" /db_xref="EnsemblGenomes-Tr:CAB13419" /db_xref="GOA:Q45479" /db_xref="InterPro:IPR001872" /db_xref="SubtiList:BG11793" /db_xref="UniProtKB/Swiss-Prot:Q45479" /translation="MLYYMIALLIIAADQLTKWLVVKNMELGQSIPIIDQVFYITSHR NTGAAWGILAGQMWFFYLITTAVIIGIVYYIQRYTKGQRLLGVALGLMLGGAIGNFID RAVRQEVVDFIHVIIVNYNYPIFNIADSSLCVGVMLLFIQMLLDSGKKKKEQ*" /label="lspA CDS" gene 1490565..1491029 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /label="lspA gene" CDS 1491031..1491942 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15078091, 15928344, 17188032, 17937767, 18032607, 20817755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389429.3" /db_xref="EnsemblGenomes-Gn:BSU15460" /db_xref="EnsemblGenomes-Tr:CAB13420" /db_xref="GOA:Q45480" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11796" /db_xref="UniProtKB/Swiss-Prot:Q45480" /translation="MNQIDITASEEQKSERIDKFLASTENDWSRTQVQQWVKDGQVVV NGSAVKANYKIQPGDQVTVTVPEPEALDVLAEPMDLDIYYEDQDVLVVNKPRGMVVHP APGHLTGTLVNGLMAHCTDLSGINGVMRPGIVHRIDKDTSGLLMVAKNDMAHESLVNQ LVNKTVTRKYTAVVHGLISHDDGTIDAPIGRDKKDRQSMTVTRDGKNAVTHFHVLERF QDFTLVECQLETGRTHQIRVHMKYIGFPLAGDPKYGPRKTIDFNGQALHAGVLGFDHP RTGEYVEFEAPLPEDMAELIENLRKNG*" /label="rluD CDS" gene 1491031..1491942 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /label="rluD gene" promotor_-35 1491937..1491944 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" promotor_-10 1491959..1491978 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" upshifts 1491973 /Source="Nicolas_upshifts" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="upshifts" misc_RNA 1491982..1492098 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaA RNA" gene 1491982..1492098 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /label="pyaA gene" CDS 1492125..1492670 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /EC_number="2.4.2.9" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7798145, 9932459, 12482852, 15716449, 17322189, 18678934" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 9932459, 12482852, 15716449, 17322189, 18678934; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional attenuator and uracil phosphoribosyltransferase activity" /protein_id="NP_389430.1" /db_xref="EnsemblGenomes-Gn:BSU15470" /db_xref="EnsemblGenomes-Tr:CAB13421" /db_xref="GOA:P39765" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR023050" /db_xref="InterPro:IPR029057" /db_xref="PDB:1A3C" /db_xref="PDB:1A4X" /db_xref="PDB:4P82" /db_xref="SubtiList:BG10712" /db_xref="UniProtKB/Swiss-Prot:P39765" /translation="MNQKAVILDEQAIRRALTRIAHEMIERNKGMNNCILVGIKTRGI YLAKRLAERIEQIEGNPVTVGEIDITLYRDDLSKKTSNDEPLVKGADIPVDITDQKVI LVDDVLYTGRTVRAGMDALVDVGRPSSIQLAVLVDRGHRELPIRADYIGKNIPTSKSE KVMVQLDEVDQNDLVAIYENE*" /label="pyrR CDS" gene 1492125..1492670 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /label="pyrR gene" downshifts complement(1492319) /Source="Nicolas_upshifts" /id="D872" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="1.85132" /MaxDrop="2.50006" /score="0.812637138" /energy="-7" /TU="NA" /idTUdmin="U1275" /TUdmin="-14864" /isTUend="FALSE" /label="downshifts" downshifts 1492661 /Source="Nicolas_upshifts" /id="D873" /incds=0 /nref=13 /ntot=149 /MaxReadThrough="8.16191" /MaxDrop="3.4492" /score="16.3570883" /energy="-11.5" /TU="U1287,U1288" /idTUdmin="U1286" /TUdmin=704 /isTUend="FALSE" /label="downshifts" misc_RNA 1492674..1492791 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaB RNA" gene 1492674..1492791 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /label="pyaB gene" CDS 1492844..1494151 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8206848, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uracil permease" /protein_id="NP_389431.2" /db_xref="EnsemblGenomes-Gn:BSU15480" /db_xref="EnsemblGenomes-Tr:CAB13422" /db_xref="GOA:P39766" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR029935" /db_xref="SubtiList:BG10992" /db_xref="UniProtKB/Swiss-Prot:P39766" /translation="MSKKKVNLGVRDVPTPFSWVSFSLQHLFAMFGSTILVPKLVGMS PAVALVTSGIGTLAYLLITKGQIPAYLGSSFAFISPIILVKATGGPGAAMVGAFLAGL VYGLIALLIRQLGTGWLMKILPPVVVGPVIIVIGLGLASTAVNMAMYADPNASELVYS LKHFSVAGVTLAITIICAIFLRGFLSLIPVLIGIIGGYLFALTQGIVNFQPVLDAKWF AVPEFIIPFKDYSPSVTLGIAAAMVPVAFVTMSEHIGHQMVLSKVVGQDFIKKPGLHR SIMGDSVATILASLIGGPPTTTYGENIGVLAITRVFSVFVIGGAAVIALCFGFIGKIS ALISSVPSAVMGGVSFLLFGIIASSGLRMLIDNKIDYENNRNLIITSVILVIGVGGAF IQVSQGGFQVSGMALAAIVGVILNLILPQAKEEQADTSEQHHI*" /label="pyrP CDS" gene 1492844..1494151 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /label="pyrP gene" misc_RNA 1494152..1494266 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaC RNA" gene 1494152..1494266 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /label="pyaC gene" CDS 1494297..1495211 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /EC_number="2.1.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8535162, 16321950, 21663747" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8535162, 16321950, 21663747; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate carbamoyltransferase" /protein_id="NP_389432.2" /db_xref="EnsemblGenomes-Gn:BSU15490" /db_xref="EnsemblGenomes-Tr:CAB13423" /db_xref="GOA:P05654" /db_xref="InterPro:IPR002082" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR036901" /db_xref="PDB:2AT2" /db_xref="PDB:3R7D" /db_xref="PDB:3R7F" /db_xref="PDB:3R7L" /db_xref="SubtiList:BG10713" /db_xref="UniProtKB/Swiss-Prot:P05654" /translation="MKHLTTMSELSTEEIKDLLQTAQELKSGKTDNQLTGKFAANLFF EPSTRTRFSFEVAEKKLGMNVLNLDGTSTSVQKGETLYDTIRTLESIGVDVCVIRHSE DEYYEELVSQVNIPILNAGDGCGQHPTQSLLDLMTIYEEFNTFKGLTVSIHGDIKHSR VARSNAEVLTRLGARVLFSGPSEWQDEENTFGTYVSMDEAVESSDVVMLLRIQNERHQ SAVSQEGYLNKYGLTVERAERMKRHAIIMHPAPVNRGVEIDDSLVESEKSRIFKQMKN GVFIRMAVIQRALQTNVKRGEAAYVISH*" /label="pyrB CDS" gene 1494297..1495211 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /label="pyrB gene" CDS 1495195..1496481 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /EC_number="3.5.2.3" /function="2: Purines, pyrimidines, nucleosides, and nucleotides" /experiment="publication(s) with functional evidences, PMID:7516791, 16522191, 21045288" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7516791, 16522191, 21045288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotase" /protein_id="NP_389433.2" /db_xref="EnsemblGenomes-Gn:BSU15500" /db_xref="EnsemblGenomes-Tr:CAB13424" /db_xref="GOA:P25995" /db_xref="InterPro:IPR002195" /db_xref="InterPro:IPR004722" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10714" /db_xref="UniProtKB/Swiss-Prot:P25995" /translation="MSYLIKNGWILNENGEKTQADIRVTGETITAIGKLDATDNETVI DAKGLLVSPGFVDLHVHFREPGGEKKETIETGAKAAARGGYTTVAAMPNTRPVPDTKE QMEWVQNRIKETSCVRVLPYASITIRQIGDEMTNFEALKEAGAFAFTDDGVGIQTAGM MYEAMKRAAAIDKAIVAHCEDNSLIYGGSVHEGTFSKANGLNGIPSVCESVHIARDVL LAEAANCHYHVCHISTKESVRVVRDAKKAGIRVTAEVSPHHLLLCDEDIPGLDTNYKM NPPLRSPEDRAALIEGLLDGTIDFIATDHAPHTEEEKNTEMKLAPFGIVGLETAFPLL YTHFVKNGSWSLKQLIDYMTIKPCEAFGLPYGTLQTGQAADITLIDLEKEAVIDKETF LSKGKNTPFNGISCTGWPVATIAAGKLAYEEGRLVK*" /label="pyrC CDS" gene 1495195..1496481 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /label="pyrC gene" CDS 1496478..1497572 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1709162, 11390694, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (small subunit, glutaminase subunit)" /protein_id="NP_389434.1" /db_xref="EnsemblGenomes-Gn:BSU15510" /db_xref="EnsemblGenomes-Tr:CAB13425" /db_xref="GOA:P25993" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10715" /db_xref="UniProtKB/Swiss-Prot:P25993" /translation="MKRRLVLENGAVFEGEAFGSLEHNMGEVVFNTGMTGYQEILSDP SYCGQIVTLTYPLIGNYGINRDDFESITPFVKGLIIKELCELPSNWRSAYTLDEYLKM KNIPGLQGIDTRKLTRMIRTAGALKGTFASSDEDIEAVLKRLNETELPRNQVSQVSAK TAYPSPGRGKRIVLVDFGMKHGILRELNKRKCDVIVVPYNITAEEVLQLKPDGIMLSN GPGDPKDVPEAIEMIKGVLGKVPLFGICLGHQLFALACGANTEKMKFGHRGSNHPVKE LATGKVALTSQNHGYTVSSISKTELEVTHIAINDDTIEGLKHKTLPAFTVQYHPEASP GPEDANHLFDRFIEMIETTEKEGEAVCQNA*" /label="pyrAA CDS" gene 1496478..1497572 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /label="pyrAA gene" CDS 1497557..1500772 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 216664, 6120161, 10732707, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (large subunit)" /protein_id="NP_389435.1" /db_xref="EnsemblGenomes-Gn:BSU15520" /db_xref="EnsemblGenomes-Tr:CAB13426" /db_xref="GOA:P25994" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR033937" /db_xref="InterPro:IPR036897" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10716" /db_xref="UniProtKB/Swiss-Prot:P25994" /translation="MPKRVDINKILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYEV ILVNSNPATIMTDTEMADRVYIEPLTPEFLTRIIRKERPDAILPTLGGQTGLNLAVEL SERGVLAECGVEVLGTKLSAIQQAEDRDLFRTLMNELNEPVPESEIIHSLEEAEKFVS QIGFPVIVRPAYTLGGTGGGICSNETELKEIVENGLKLSPVHQCLLEKSIAGYKEIEY EVMRDSQDHAIVVCNMENIDPVGIHTGDSIVVAPSQTLSDREYQLLRNVSLKLIRALG IEGGCNVQLALDPDSFQYYIIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLSLDEM MNPVTGKTYAAFEPALDYVVSKIPRWPFDKFESANRKLGTQMKATGEVMAIGRTLEES LLKAVRSLEADVYHLELKDAADISDELLEKRIKKAGDERLFYLAEAYRRGYTVEDLHE FSAIDVFFLHKLFGIVQFEKELKANAGDTDVLRRAKELGFSDQYISREWKMKESELYS LRKQAGIAPVFKMVDTCAAEFESETPYFYSTYEEENESVVTDKKSVMVLGSGPIRIGQ GVEFDYATVHSVWAIKQAGYEAIIVNNNPETVSTDFSISDKLYFEPLTIEDVMHIIDL EQPMGVVVQFGGQTAINLADELSARGVKILGTSLEDLDRAEDRDKFEQALGELGVPQP LGKTATSVNQAVSIASDIGYPVLVRPSYVLGGRAMEIVYHEEELLHYMKNAVKINPQH PVLIDRYLTGKEIEVDAVSDGETVVIPGIMEHIERAGVHSGDSIAVYPPQSLTEDIKK KIEQYTIALAKGLNIVGLLNIQFVLSQGEVYVLEVNPRSSRTVPFLSKITGIPMANLA TKIILGQKLAAFGYTEGLQPEQQGVFVKAPVFSFAKLRRVDITLGPEMKSTGEVMGKD STLEKALYKALIASGIQIPNYGSVLLTVADKDKEEGLAIAKRFHAIGYNILATEGTAG YLKEASIPAKVVGKIGQDGPNLLDVIRNGEAQFVINTLTKGKQPARDGFRIRRESVEN GVACLTSLDTAEAILRVLESMTFRADQMPAVNTNQEAAVTI*" /label="pyrAB CDS" gene 1497557..1500772 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /label="pyrAB gene" CDS 1500769..1501539 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /EC_number="1.3.98.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:169225, 10545205, 11188687, 15299876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 169225, 10545205, 11188687, 15299876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (electron transfer subunit)" /protein_id="NP_389436.1" /db_xref="EnsemblGenomes-Gn:BSU15530" /db_xref="EnsemblGenomes-Tr:CAB13427" /db_xref="GOA:P25983" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR012165" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR019480" /db_xref="InterPro:IPR023455" /db_xref="InterPro:IPR037117" /db_xref="SubtiList:BG10717" /db_xref="UniProtKB/Swiss-Prot:P25983" /translation="MKKAYLTVCSNQQIADRVFQMVLKGELVQGFTTPGQFLHLKVSE AVTPLLRRPISIADVNFEKNEVTIIYRVDGEGTRLLSLKQQGELVDVLGPLGNGFPVN EVQPGKTALLVGGGVGVPPLQELSKRLIEKGVNVIHVLGFQSAKDVFYEEECRQYGDT YVATADGSYGETGFVTDVIKRKKLEFDILLSCGPTPMLKALKQEYAHKEVYLSMEERM GCGIGACFACVCHTNESETSYVKVCLDGPVFKAQEVAL*" /label="pyrK CDS" gene 1500769..1501539 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /label="pyrK gene" CDS 1501539..1502474 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /EC_number="1.3.1.15" /experiment="publication(s) with functional evidences, PMID:4380263, 10545205" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4380263, 10545205; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (catalytic subunit)" /protein_id="NP_389437.1" /db_xref="EnsemblGenomes-Gn:BSU15540" /db_xref="EnsemblGenomes-Tr:CAB13428" /db_xref="GOA:P25996" /db_xref="InterPro:IPR001295" /db_xref="InterPro:IPR005720" /db_xref="InterPro:IPR012135" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024920" /db_xref="InterPro:IPR033888" /db_xref="SubtiList:BG10718" /db_xref="UniProtKB/Swiss-Prot:P25996" /translation="MLEVKLPGLDLKNPIIPASGCFGFGKEFSRFYDLSCLGAIMIKA TTKEPRFGNPTPRVAETGAGMLNAIGLQNPGLDSVLHHELPWLEQFDTPIIANVAGSQ VDDYVEVAEHISKAPNVHALELNISCPNVKTGGIAFGTNPEMAADLTKAVKEVSDVPV YVKLSPNVANITEIALAIEEAGADGLTMINTLIGMRLDLKTGKPILANKTGGLSGPAV KPVAIRMVYEVSQMVNIPIIGMGGVQTAEDALEFLLAGASAVAVGTANFVNPFACPEI IEQLPSVLLQYGYQSIEECIGRSWNHEKQPAHHRA*" /label="pyrD CDS" gene 1501539..1502474 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /label="pyrD gene" CDS 1502443..1503162 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /EC_number="4.1.1.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10681442, 11390694, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10681442, 11390694, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotidine 5'-phosphate decarboxylase" /protein_id="NP_389438.1" /db_xref="EnsemblGenomes-Gn:BSU15550" /db_xref="EnsemblGenomes-Tr:CAB13429" /db_xref="GOA:P25971" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014732" /db_xref="InterPro:IPR018089" /db_xref="PDB:1DBT" /db_xref="SubtiList:BG10719" /db_xref="UniProtKB/Swiss-Prot:P25971" /translation="MKNNLPIIALDFASAEETLAFLAPFQQEPLFVKVGMELFYQEGP SIVKQLKERNCELFLDLKLHDIPTTVNKAMKRLASLGVDLVNVHAAGGKKMMQAALEG LEEGTPAGKKRPSLIAVTQLTSTSEQIMKDELLIEKSLIDTVVHYSKQAEESGLDGVV CSVHEAKAIYQAVSPSFLTVTPGIRMSEDAANDQVRVATPAIAREKGSSAIVVGRSIT KAEDPVKAYKAVRLEWEGIKS*" /label="pyrF CDS" gene 1502443..1503162 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /label="pyrF gene" CDS 1503141..1503791 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /EC_number="2.4.2.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9305779, 22447609, 23405251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotate phosphoribosyltransferase" /protein_id="NP_389439.1" /db_xref="EnsemblGenomes-Gn:BSU15560" /db_xref="EnsemblGenomes-Tr:CAB13430" /db_xref="GOA:P25972" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR004467" /db_xref="InterPro:IPR023031" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10720" /db_xref="UniProtKB/Swiss-Prot:P25972" /translation="MGGNQILKQIIAKHLLDIQAVFLRPNEPFTWASGILSPIYCDNR LTLSFPEVRNDVASGISKLVKEHFPEAEMIAGTATAGIPHAALAADHLNLPMCYVRSK PKAHGKGNQIEGAVQEGQKTVVIEDLISTGGSVLEACAALQAAGCEVLGVVSIFTYGL PKAEEAFAKAELPYYSLTDYDTLTEVALENGNIHSDDLKKLQTWKRNPESKDWFKK*" /label="pyrE CDS" gene 1503141..1503791 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /label="pyrE gene" downshifts 1503793 /Source="Nicolas_upshifts" /id="D874" /incds=0 /nref=17 /ntot=184 /MaxReadThrough="3.91018" /MaxDrop="5.49939" /score="33.4515727" /energy="-9" /TU="U1287,U1288" /idTUdmin="U1287" /TUdmin="-115" /isTUend="FALSE" /label="downshifts" S_feature 1503838..1503910 /Source="Nicolas_S_feature" /locus_tag="new_1630017_1630089" /HighExp="Cold, Gly, MG 5, S0, LPh, M/G, GM 60, MG t5, Mal, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S568" promotor_-35 1503890..1503897 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1503911..1503930 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1503912 /Source="Nicolas_upshifts" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1503936..1504041 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /label="mswE RNA" gene 1503936..1504041 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /label="mswE gene" S_feature 1504042..1504202 /Source="Nicolas_S_feature" /locus_tag="new_1630221_1630381" /HighExp="MG 10, B60, MG 5, MG t5, M9-exp, MG 25, MG 60, MG 15, GM 90, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S569" CDS 1504203..1504904 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10094622, 11004190, 12072441, 16267287, 18456801" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 11004190, 12072441, 16267287, 18456801; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(phospho)adenosine phosphosulfate reductase" /protein_id="NP_389440.1" /db_xref="EnsemblGenomes-Gn:BSU15570" /db_xref="EnsemblGenomes-Tr:CAB13431" /db_xref="GOA:P94498" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11930" /db_xref="UniProtKB/Swiss-Prot:P94498" /translation="MLTYDNWEEPTITFPEDDPYKGALSVLKWAYGHYGDQLVYACSF GIEGIVLIDLIYKVKKDAEIVFLDTGLHFKETYETIERVKERYPGLNIILKKPDLTLE EQAEEHGDKLWEREPNQCCYLRKVVPLREALSGHPAWLSGLRRDQGPSRANTNFLNKD EKFKSVKVCPLIHWTWKDIWRYTSRNELDYNPLHDQGYPSIGCAPCTSPAFTAEDLRS GRWNGMAKTECGLHE*" /label="cysH CDS" gene 1504203..1504904 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /label="cysH gene" CDS 1504916..1505980 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 10784039, 11004190, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 10784039, 11004190, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfate permease" /protein_id="NP_389441.1" /db_xref="EnsemblGenomes-Gn:BSU15580" /db_xref="EnsemblGenomes-Tr:CAB13432" /db_xref="GOA:O34734" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13377" /db_xref="UniProtKB/Swiss-Prot:O34734" /translation="MELAAILFSLFFAMNIGASGAAASMGVAYGSGAIKKKTYALILC AVGVFAGAVIGGGEVVKTISSGIIPEQTITLTIVCIIIGAAALSLFTANLLGIPLSTS EVTVGAVVGVGVAYKVLFVNNLLIIVSFWVFVPLFAFGFTYFVSKLFRYFKIEVKSSK KQKILGIVLLVAGFFEAFSAGMNNVANAVGPLVAAGVLDVGKGTLYGGAFVALGALLL GRRVLETNGKKITRFSKGEGILLSGTGAGLVIISSVFGMPVPLAQVTSSSIIGIGMAK NGPNVFHKQVVQTMLKVWIVSPFLSLSISYLLVSLFLKADYYSIFIMVSVLLAAGGAI SLTKAIRKERRSVHEQGGGI*" /label="cysP CDS" gene 1504916..1505980 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /label="cysP gene" CDS 1506029..1507177 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /EC_number="2.7.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 11004190, 11274114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfate adenylyltransferase" /protein_id="NP_389442.1" /db_xref="EnsemblGenomes-Gn:BSU15590" /db_xref="EnsemblGenomes-Tr:CAB13433" /db_xref="GOA:O34764" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13378" /db_xref="UniProtKB/Swiss-Prot:O34764" /translation="MSLAPHGGTLVNRVDESYDVSGIQKEIELDLISFADLELIGIGA YSPIEGFFNEKDYVSVVENMRLSSGVVWSLPITLPVDAQKAAELSLGETVKLTYEGET YGVIQIEDLYVPDKQKEAVNVYKTDEQEHPGVKKLFSRGNTYVGGPITLIKKASKQFP EFTFEPSETRRQFAEKGWETIVGFQTRNPVHRAHEYIQKTALETVDGLFLNPLVGETK SDDIPADVRMESYQVLLDHYYPKDRVFLGVFLAAMRYAGPREAIFHALVRKNYGCTHF IVGRDHAGVGDYYGTYEAQELFDTFKPEELGITPLKFEHSFFCKKCGNMGTAKTCPHG REHHVILSGTKVRGMLRDGVLPPAEFSRKEVVEVLIKGMKKKEEVGVS*" /label="sat CDS" gene 1506029..1507177 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /label="sat gene" upshifts complement(1506118) /Source="Nicolas_upshifts" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1506130..1506134) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1506152..1506153) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1507190..1507783 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /EC_number="2.7.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1332767, 10094622, 11004190, 19067028, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylylsulfate kinase" /protein_id="NP_389443.1" /db_xref="EnsemblGenomes-Gn:BSU15600" /db_xref="EnsemblGenomes-Tr:CAB13434" /db_xref="GOA:O34577" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13379" /db_xref="UniProtKB/Swiss-Prot:O34577" /translation="MTNRDIVWHEASITKEEYQQKNKHKSSILWLTGLSGSGKSTIAN AAARELFEQGYQVIVLDGDNIRHGLNRDLGFSDEDRKENIRRIGEVAKLFVQQGTIVI TAFISPFREDRQQVRELVEAGEFNEVYIKCDLDICEQRDPKGLYKKARNGEIPFFTGI DSPYEEPEAPELVLDSGQHDREACKNQLIEFVKQKLS*" /label="cysC CDS" gene 1507190..1507783 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /label="cysC gene" S_feature 1507784..1507881 /Source="Nicolas_S_feature" /locus_tag="new_1633963_1634060" /HighExp="MG 10, B36, MG 5, MG t5, B60, MG 15, MG 90, MG-0.2, MG 60, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S570" CDS 1507882..1508655 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /EC_number="2.1.1.107" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1906874, 11004190, 10094622, 19154787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III and precorrin-1 C-methyltransferase" /protein_id="NP_389444.1" /db_xref="EnsemblGenomes-Gn:BSU15610" /db_xref="EnsemblGenomes-Tr:CAB13435" /db_xref="GOA:O34744" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG13380" /db_xref="UniProtKB/Swiss-Prot:O34744" /translation="MGKVYIVGAGPGDPDLLTIKALKAIEKADVILYDRLVNKEILQY AKEQADLIYCGKLPDFHTMKQETINRFLVKYAQKGKMVVRLKGGDPFVFGRGGEEAEC LSENGIPFEIIPGITSGIAAAAYAGIPVTHRDAGSNVAFVTGHYKKEEDFEEKWKALA TGIDTLVIYMGIKNVQQIERKLLENGRDGSTPAAFIHWGTTDKQKSVFCTVDTLSETV IKENITNPSLIVIGNVVNYHYKLEWFESELKKQDLSEAL*" /label="sumT CDS" gene 1507882..1508655 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /label="sumT gene" promotor_-35 1508560..1508567 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1508582..1508601 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1508583 /Source="Nicolas_upshifts" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="upshifts" CDS 1508658..1509443 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /EC_number="4.99.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirohydrochlorin ferrochelatase" /protein_id="NP_389445.1" /db_xref="EnsemblGenomes-Gn:BSU15620" /db_xref="EnsemblGenomes-Tr:CAB13436" /db_xref="GOA:O34632" /db_xref="InterPro:IPR002762" /db_xref="SubtiList:BG13381" /db_xref="UniProtKB/Swiss-Prot:O34632" /translation="MKQAILYVGHGSRVKKAQQEAAAFLEGCKAHISVPVQEISFLEL QEPTIETGFEACVKQGATHIAVVPLLLLTAAHAKHDIPEEIVRVASRYPSVRISYGKP IGIDEEVVKAVYHRMKDIGVPYENARVVLIGRGSSDPDVKRDVTGIANLLQEMVPVKE VIPCFLTACGPNYKEVFSELEKDDGITTFIVPYLLFTGMLMNEIEREVQKLKAHNPNV YLSSYIGFHPHVKNAFLNRVRETAANSEGQFDFDGGSYASAAH*" /label="sirB CDS" gene 1508658..1509443 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /label="sirB gene" CDS 1509424..1509912 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /EC_number="1.3.1.76" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752, 18588505; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="precorrin-2 dehydrogenase" /protein_id="NP_389446.1" /db_xref="EnsemblGenomes-Gn:BSU15630" /db_xref="EnsemblGenomes-Tr:CAB13437" /db_xref="GOA:O34813" /db_xref="InterPro:IPR006367" /db_xref="InterPro:IPR028161" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13382" /db_xref="UniProtKB/Swiss-Prot:O34813" /translation="MLPLHISLEKKKVVIAGGGSIALRRLKTVISEGADITLVSPDVE PEIKQMAEERRIKWEKRTIEKEDYLNAFFIIAATDNAAVNKEIAQSASPFQLVNCVSD AELGNVYMPKIVKRGHVTVSVSTSGASPKHTKELAENVDKLIDGDFVAEVNRLYQMRR KK*" /label="sirC CDS" gene 1509424..1509912 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /label="sirC gene" downshifts 1509892 /Source="Nicolas_upshifts" /id="D875" /incds=0 /nref=256 /ntot=267 /MaxReadThrough="2.85828" /MaxDrop="8.90139" /score="26.5923498" /energy="-16.6" /TU="U1289" /idTUdmin="U1291" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1509939) /Source="Nicolas_upshifts" /id="D876" /incds=0 /nref=149 /ntot=238 /MaxReadThrough="1.71588" /MaxDrop="5.36964" /score="15.559144" /energy="-16.6" /TU="NA" /idTUdmin="U1292" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1509952..1511670) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11238985, 17586671, 24646681, 28294433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA modification protein" /protein_id="NP_389447.1" /db_xref="EnsemblGenomes-Gn:BSU15640" /db_xref="EnsemblGenomes-Tr:CAB13438" /db_xref="InterPro:IPR008532" /db_xref="SubtiList:BG13383" /db_xref="UniProtKB/Swiss-Prot:O34693" /translation="MHMSFDGMFTYGMTHELNEKIMGGRITKIHQPYKHDVIFHIRAK GKNQKLLLSAHPSYSRVHITAQAYENPSEPPMFCMLLRKHIEGGFIEKIEQAGLDRIM IFHIKSRNEIGDETVRKLYVEIMGRHSNIILTDAAENVIIDGLKHLSPSMNSYRTVLP GQDYKLPPAQDKISPLEASEDDILRHLSFQEGRLDKQIVDHFSGVSPLFAKEAVHRAG LANKVTLPKALLALFAEVKEHRFIPNITTVNGKEYFYLLELTHLKGEARRFDSLSELL DRFYFGKAERDRVKQQAQDLERFVVNERKKNANKIKKLEKTLEYSENAKEFQLYGELL TANLYMLKKGDKQAEVINYYDEESPTITIPLNPNKTPSENAQAYFTKYQKAKNSVAVV EEQIRLAQEEIEYFDQLIQQLSSASPRDISEIREELVEGKYLRPKQQKGQKKQKPHNP VLETYESTSGLTILVGKNNRQNEYLTTRVAARDDIWLHTKDIPGSHVVIRSSEPDEQT IMEAATIAAYFSKAKDSSSVPVDYTKIRHVKKPNGAKPGFVTYDSQHTVFVTPDADTV IKLKKS*" /label="fbnA CDS" gene complement(1509952..1511670) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /label="fbnA gene" promotor_-10 complement(1511692..1511711) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1511706..1511711 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-35" upshifts complement(1511706) /Source="Nicolas_upshifts" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1511724..1511729) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1511727..1511745 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-10" upshifts 1511731 /Source="Nicolas_upshifts" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="upshifts" CDS 1511786..1514458 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12161109, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12161109, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="P-type calcium transport ATPase (sporulation)" /protein_id="NP_389448.1" /db_xref="EnsemblGenomes-Gn:BSU15650" /db_xref="EnsemblGenomes-Tr:CAB13439" /db_xref="GOA:O34431" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR004014" /db_xref="InterPro:IPR005782" /db_xref="InterPro:IPR006068" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13384" /db_xref="UniProtKB/Swiss-Prot:O34431" /translation="MKFHEMGQTDLLEATNTSMKQGLTEKEVKKRLDKHGPNELQEGK KTSALLLFFAQFKDFMVLVLLAATLISGFLGEYVDAVAIIAIVFVNGILGFFQERRAE QSLQALKELSTPHVMALREGSWTKIPSKELVPGDIVKFTSGDRIGADVRIVEARSLEI EESALTGESIPVVKHADKLKKPDVSLGDITNMAFMGTIVTRGSGVGVVVGTGMNTAMG KIADMLESAGTLSTPLQRRLEQLGKILIVVALLLTVLVVAVGVIQGHDLYSMFLAGVS LAVAAIPEGLPAIVTVALSLGVQRMIKQKSIVRKLPAVETLGCASIICSDKTGTMTQN KMTVTHVWSGGKTWRVAGAGYEPKGSFTLNEKEISVNEHKPLQQMLLFGALCNNSNIE KRDGEYVLDGDPTEGALLTAARKGGFSKEFVESNYRVIEEFPFDSARKMMTVIVENQD RKRYIITKGAPDVLMQRSSRIYYDGSAALFSNERKAETEAVLRHLASQALRTIAVAYR PIKAGETPSMEQAEKDLTMLGLSGIIDPPRPEVRQAIKECREAGIKTVMITGDHVETA KAIAKDLRLLPKSGKIMDGKMLNELSQEELSHVVEDVYVFARVSPEHKLKIVKAYQEN GHIVAMTGDGVNDAPAIKQADIGVSMGITGTDVAKEASSLVLVDDNFATIKSAIKEGR NIYENIRKFIRYLLASNVGEILVMLFAMLLALPLPLVPIQILWVNLVTDGLPAMALGM DQPEGDVMKRKPRHPKEGVFARKLGWKVVSRGFLIGVATILAFIIVYHRNPENLAYAQ TIAFATLVLAQLIHVFDCRSETSVFSRNPFQNLYLIGAVLSSILLMLVVIYYPPLQPI FHTVAITPGDWMLVIGMSAIPTFLLAGSLLTRKK*" /label="tcaB CDS" gene 1511786..1514458 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /label="tcaB gene" promotor_-10 complement(1513191..1513210) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1513202) /Source="Nicolas_upshifts" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1513225..1513232) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1514464..1514483 /Source="Nicolas_upshift_promotors" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1514467..1514540 /Source="Nicolas_S_feature" /locus_tag="new_1640646_1640719" /HighExp="LPhT, LBGstat, T3.0H, H2O2, T3.30H, Salt, B60, Lbexp, UNK1, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.994, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S571" upshifts 1514467 /Source="Nicolas_upshifts" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1514541..1515416 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389449.1" /db_xref="EnsemblGenomes-Gn:BSU15660" /db_xref="EnsemblGenomes-Tr:CAB13440" /db_xref="InterPro:IPR005229" /db_xref="InterPro:IPR013527" /db_xref="InterPro:IPR013551" /db_xref="SubtiList:BG13385" /db_xref="UniProtKB/Swiss-Prot:O34441" /translation="MIRSMTGFGSASKTQDDLSVSVELKSVNYRFKEVNARLPRPLLY FEDKLKQTILQHIQRGRIELFVSVDSDMLVEKRLEIDWPLLDEFVAAARDMKKRYQLS AEPDVMDFFKLDHVVQVHEEQTQNDKLEALIIDAAEEAVKGLCEMREKEGLLLAKDCL MHIDQLEELVRETELLAADVVSRYRERLYARIKEWTEDVLDESRLVTECAIFADRSDI TEEITRLKSHFAQFRDILASGGAVGRKLDFLVQELNREANTIGSKANDHQITKLVVEM KSSIEKIKEQVQNIE*" /label="yloC CDS" gene 1514541..1515416 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /label="yloC gene" CDS 1515493..1515762 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116, 23396918, 23646920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116, 23396918, 23646920; Product type r: regulator" /codon_start=1 /transl_table=11 /product="essential sporulation DNA binding protein; regulator of biofilm formation" /protein_id="NP_570902.1" /db_xref="EnsemblGenomes-Gn:BSU15670" /db_xref="EnsemblGenomes-Tr:CAE01452" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG14185" /db_xref="UniProtKB/Swiss-Prot:Q7WY72" /translation="MTIKLINIGFGNIISANRMISIVSPESAPIKRMIQDARDRGMLI DATYGRRTRAVVVMDSDHIILSAVQPETVAHRLSVKEEIMDEGQG*" /label="remA CDS" gene 1515493..1515762 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /label="remA gene" misc_feature complement(1515573..1515577) /Source="Nicolas_upshift_promotors" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1515578) /Source="Nicolas_upshifts" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1515770..1516384 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /EC_number="2.7.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17012781, 24722991" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17012781, 24722991; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanylate kinase" /protein_id="NP_389450.2" /db_xref="EnsemblGenomes-Gn:BSU15680" /db_xref="EnsemblGenomes-Tr:CAB13441" /db_xref="GOA:O34328" /db_xref="InterPro:IPR008144" /db_xref="InterPro:IPR008145" /db_xref="InterPro:IPR017665" /db_xref="InterPro:IPR020590" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13386" /db_xref="UniProtKB/Swiss-Prot:O34328" /translation="MKERGLLIVLSGPSGVGKGTVRQAIFSQEDTKFEYSISVTTRSP REGEVNGVDYFFKTRDEFEQMIADNKLLEWAEYVGNYYGTPVDYVEQTLQDGKDVFLE IEVQGALQVRNAFPEGLFIFLAPPSLSELKNRIVTRGTETDALIENRMKAAKAEIEMM DAYDYVVENDNVETACDKIKAIVLAEHLKRERVAPRYKKMLEVE*" /label="gmk CDS" gene 1515770..1516384 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /label="gmk gene" CDS 1516388..1516591 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12089032, 16159791, 17233676, 24476911, 25878038; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega subunit of RNA polymerase" /protein_id="NP_389451.1" /db_xref="EnsemblGenomes-Gn:BSU15690" /db_xref="EnsemblGenomes-Tr:CAB13442" /db_xref="GOA:O35011" /db_xref="InterPro:IPR003716" /db_xref="InterPro:IPR006110" /db_xref="InterPro:IPR012293" /db_xref="InterPro:IPR036161" /db_xref="SubtiList:BG13387" /db_xref="UniProtKB/Swiss-Prot:O35011" /translation="MLDPSIDSLMNKLDSKYTLVTVSARRAREMQIKKDQMIEHTISH KYVGKALEEIDAGLLSFEKEDRE*" /label="rpoZ CDS" gene 1516388..1516591 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /label="rpoZ gene" downshifts 1516580 /Source="Nicolas_upshifts" /id="D877" /incds=0 /nref=118 /ntot=257 /MaxReadThrough="5.65143" /MaxDrop="4.7291" /score="-8.13961715" /energy="-7.7" /TU="U1293,U1295" /idTUdmin="U1293" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" CDS 1516672..1517892 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /EC_number="4.1.1.36" /EC_number="6.3.2.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11278255, 11358972, 12140293, 14686929, 15530362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coenzyme A biosynthesis bifunctional protein CoaBC; phosphopantothenoylcysteine synthetase/decarboxylase" /protein_id="NP_389452.1" /db_xref="EnsemblGenomes-Gn:BSU15700" /db_xref="EnsemblGenomes-Tr:CAB13443" /db_xref="GOA:O35033" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR005252" /db_xref="InterPro:IPR007085" /db_xref="InterPro:IPR035929" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG13388" /db_xref="UniProtKB/Swiss-Prot:O35033" /translation="MLNNRNVLLCVSGGIAVYKACALTSKLVQAGANVKVIMTESACR FVSPLTFQALSRHEVYTDTFKEQNPSVISHIDAADWADLIIVAPATANVIGKLANGIA DDMLTTTLLAATAPVWIAPAMNVHMYDHPAVKRNISVLYQDGYCFIEPSEGYLACGYV GKGRLEEPENIVKLAEKHFAEETSAPLEGKHVVITAGPTREAIDPVRFFTNKSTGKMG YALAEAAVQLGARVILISGPVSLDQPKGLAEFIPVQSAADMREAVLSVYDASDIVIKT AAVADFTPKTVFDHKMKKQDGGMTLELKRTVDILKELGEKKKEQILVGFAAETQDIEH YARKKLAAKNLDLIVANDVKANGAGFGADTNIVTIFFKDGHKRELPIMSKLDVSFEIL QEIAALSKQTGERS*" /label="coaBC CDS" gene 1516672..1517892 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /label="coaBC gene" S_feature complement(1517731..1518306) /Source="Nicolas_S_feature" /locus_tag="new_1643910_1644485_c" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, B60, LPhT, HiTm, Heat" /AntisenseName="priA" /AntisenseCor="-5.1213364637925501E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S572" CDS 1517889..1520306 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10572298, 11917020, 12682299, 21170359, 22720735, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572298, 11917020, 12682299, 21170359, 22720735, 28527403; Product type f : factor" /codon_start=1 /transl_table=11 /product="primosomal replication factor Y (primosomal protein N')" /protein_id="NP_389453.1" /db_xref="EnsemblGenomes-Gn:BSU15710" /db_xref="EnsemblGenomes-Tr:CAB13444" /db_xref="GOA:P94461" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005259" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11963" /db_xref="UniProtKB/Swiss-Prot:P94461" /translation="MNFAEVIVDVSTKNIDRPFDYKIPDHLKGMIKTGMRVIVPFGPR KIQGFVTAVKEASDLSGKSVKEVEDLLDLTPVLTEELMILSSWLSDKTLSFKITALQA MLPAALKAKYEKELKIAHGADLPPQVERLFSETKTLLYSDIPDHETLKLIQRHVQKGD IDVTYKVAQKTNKKMVRHIQANASKEELAKQAEGLSRQAAKQQAILHFLISEPEGVKI PAAELCKKTDTSSATIKTLIQKGLLKESYEEVYRDPYQDKMFKKTEPLPLTDEQRAAF EPIRETLDSDEHKVFLLHGVTGSGKTEIYLQSIEKVLAKGKEAIVLVPEISLTPQMVN RFKGRFGSQVAVMHSGLSTGEKYDEWRKIHRKEVRLVVGARSAIFAPFENLGMIIIDE EHESSYKQEEMPRYHAKEVAIKRAEHHSCPVVLGSATPTLESYARAQKGVYELLSLKH RVNHRVMPEVSLVDMREELRNGNRSMFSVELMEKLEETIAKGEQAVLFLNKRGYSSFV MCRDCGYVPQCPHCDISMTYHRYGQRLKCHYCGHEEPVPHTCPECASEHIRFFGTGTQ RVEEELTKVLPSARVIRMDVDTTSRKGAHEKLLSAFGEGKADILLGTQMIAKGLDFPN VTLVGVLSADTTLHIPDFRSAEKTFQLLTQVSGRAGRHEKPGHVIIQTYTPSHYSIQL TKTHDYETFYQHEMAHRREQSYPPYYYLALVTVSHEEVAKAAVTAEKIAHFLKANCGA DTKILGPSASPIARIKDRYRYQCVIKYKQETQLSALLKKILEHYKREIEQKHVMISID MNPYMMM*" /label="priA CDS" gene 1517889..1520306 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /label="priA gene" promotor_-10 complement(1518302..1518320) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1518306) /Source="Nicolas_upshifts" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1518334..1518340) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1520157..1520161 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1520177..1520196 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1520188 /Source="Nicolas_upshifts" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1520333..1520815 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /EC_number="3.5.1.88" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11429456, 16014871, 16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16014871, 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide deformylase" /protein_id="NP_389454.1" /db_xref="EnsemblGenomes-Gn:BSU15720" /db_xref="EnsemblGenomes-Tr:CAB13445" /db_xref="GOA:P94462" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11933" /db_xref="UniProtKB/Swiss-Prot:P94462" /translation="MAVKKVVTHPAEVLETPAETVTVFDKKLKKLLDDMYDTMLEMDG VGLAAPQIGILKRAAVVEIGDDRGRIDLVNPEILEKSGEQTGIEGCLSFPNVYGDVTR ADYVKVRAFNRQGKPFILEARGFLARAVQHEMDHLDGVLFTSKISKYYTEDELADMEG *" /label="defA CDS" gene 1520333..1520815 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /label="defA gene" CDS 1520820..1521773 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /EC_number="2.1.2.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA formyltransferase" /protein_id="NP_389455.1" /db_xref="EnsemblGenomes-Gn:BSU15730" /db_xref="EnsemblGenomes-Tr:CAB13446" /db_xref="GOA:P94463" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR005793" /db_xref="InterPro:IPR005794" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036477" /db_xref="InterPro:IPR037022" /db_xref="SubtiList:BG11937" /db_xref="UniProtKB/Swiss-Prot:P94463" /translation="MTRIVFMGTPDFSVPVLRTLIEDGYEVVGVVTQPDRPKGRKKVL TPPPVKEEALRHGIPVLQPEKVRLTEEIEKVLALKPDLIVTAAFGQILPKELLDSPKY GCINVHASLLPELRGGAPIHYSILQGKKKTGITIMYMVEKLDAGDMISKVEVDIEETD NVGTLHDKLSVAGAKLLSETVPNVIAGSISPEKQDEEKATYAPNIKREQELLDWSRTG EELYNQIRGLNPWPVAYTTLNGQNLKIWASKKIAAPTTAEPGTVVAVEKEGIIVATGN ETALLLTELQPAGKKRMKGEDFVRGAHVEAGDVLGVNNEKN*" /label="fmt CDS" gene 1520820..1521773 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /label="fmt gene" CDS 1521760..1523103 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /EC_number="2.1.1.176" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14656444, 23729652, 27698115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA-binding Sun protein; 16S rRNA m5C967 methyltransferase, S-adenosyl-L-methionine-dependent" /protein_id="NP_389456.1" /db_xref="EnsemblGenomes-Gn:BSU15740" /db_xref="EnsemblGenomes-Tr:CAB13447" /db_xref="GOA:P94464" /db_xref="InterPro:IPR001678" /db_xref="InterPro:IPR004573" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR018314" /db_xref="InterPro:IPR023267" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG12253" /db_xref="UniProtKB/Swiss-Prot:P94464" /translation="MKKTSVRDIALEALIKLEQNQAYSNLLLKSVIKSNELSDQNRGL LTELVYGTLQNKIALDYMLKPFINKPQKVKPWVIQLLRLSLYQMEYLEKIPDRAAIHE AVEIAKIRGHKGIASFVNGVLRSIQREGVPSFDAIEDPVRRLATETSHPEWLVKEWAD AYGFEAAEKICRIHLIPPKQTLRVNQMKADRAELLDQMAAEGIEVEKGDLAEDAVKLL KGTIAGTHFFQNGEVSIQDESSMLVARALDPKSDETVLDACAAPGGKSAHIAELMKNK GSVTSLDLHKHKVKLIKEAADRLGLTIIHAETMDARKAGETFENEQFDRILVDAPCSG FGVIRRKPDMKYTKKPDDSARLAEIQLSILREIAPLVKKGGTLVYSTCTMDRTENDEV IHAFIQEHPDFEPDLSLEKRLPEKVRPFVRDGRLQILPHYFGTDGFFICSMRKKG*" /label="rsmB CDS" gene 1521760..1523103 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /label="rsmB gene" CDS 1523107..1524198 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /EC_number="2.1.1.192" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8973346, 18307109, 20184321, 21368151, 22891362, 27081063, 27902775; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2A2503 methyltransferase and tRNA A37 C2 methyltransferase" /protein_id="NP_389457.1" /db_xref="EnsemblGenomes-Gn:BSU15750" /db_xref="EnsemblGenomes-Tr:CAB13448" /db_xref="GOA:O34617" /db_xref="InterPro:IPR004383" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR027492" /db_xref="SubtiList:BG13389" /db_xref="UniProtKB/Swiss-Prot:O34617" /translation="MAELNKTKVRKELRTERPSIYSFELDEIKQWLTDNGEKPFRAAQ IFEWLYEKRVSSFEDMTNLSKDLREKLNTRFVLTTLKTAVKQTSQDGTMKFLFELHDG YTIETVLMRHEYGNSVCVTTQVGCRIGCTFCASTLGGLKRNLEAGEIVAQVVKVQKAL DETDERVSSVVIMGIGEPFDNFNEMLAFLKIINHDKGLNIGARHITVSTSGIIPKIYE FADQQMQINFAISLHAPNTEIRSRLMPINRAYKLPDLMEAVKYYINKTGRRISFEYGL FGGVNDQVEHAEELADLLEGVKCHVNLIPVNYVPERDYVRTPRDQIFAFEKTLKSRGV NVTIRREQGHDIDAACGQLRAKERQDETR*" /label="rlmN CDS" gene 1523107..1524198 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /label="rlmN gene" CDS 1524205..1524969 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /EC_number="3.1.3.16" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 17693724, 22720735, 24390483, 25012659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 17693724, 22720735, 24390483, 25012659; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="multitarget phosphorylated protein phosphatase" /protein_id="NP_389458.1" /db_xref="EnsemblGenomes-Gn:BSU15760" /db_xref="EnsemblGenomes-Tr:CAB13449" /db_xref="GOA:O34779" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR015655" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG13390" /db_xref="UniProtKB/Swiss-Prot:O34779" /translation="MLTALKTDTGKIRQHNEDDAGIFKGKDEFILAVVADGMGGHLAG DVASKMAVKAMGEKWNEAETIPTAPSECEKWLIEQILSVNSKIYDHAQAHEECQGMGT TIVCALFTGKTVSVAHIGDSRCYLLQDDDFVQVTEDHSLVNELVRTGEISREDAEHHP RKNVLTKALGTDQLVSIDTRSFDIEPGDKLLLCSDGLTNKVEGTELKDILQSDSAPQE KVNLLVDKANQNGGEDNITAVLLELALQVEEGEDQC*" /label="prpC CDS" gene 1524205..1524969 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /label="prpC gene" downshifts 1524258 /Source="Nicolas_upshifts" /id="D878" /incds=0 /nref=5 /ntot=126 /MaxReadThrough="6.12318" /MaxDrop="3.8594" /score="-7.80200272" /energy="-10" /TU="U1295,U1298" /idTUdmin="U1300" /TUdmin="-4708" /isTUend="FALSE" /label="downshifts" CDS 1524963..1526909 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /EC_number="2.7.11.1" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 18984160, 24390483, 25845974, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 18984160, 24390483, 25845974, 26102633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine/threonine kinase" /protein_id="NP_389459.1" /db_xref="EnsemblGenomes-Gn:BSU15770" /db_xref="EnsemblGenomes-Tr:CAB13450" /db_xref="GOA:O34507" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR008271" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13391" /db_xref="UniProtKB/Swiss-Prot:O34507" /translation="MLIGKRISGRYQILRVIGGGGMANVYLAEDIILDREVAIKILRF DYANDNEFIRRFRREAQSASSLDHPNIVSIYDLGEEDDIYYIVMEYVEGMTLKEYITA NGPLHPKEALNIMEQIVSAIAHAHQNQIVHRDIKPHNILIDHMGNIKVTDFGIATALS STTITHTNSVLGSVHYLSPEQARGGLATKKSDIYALGIVLFELLTGRIPFDGESAVSI ALKHLQAETPSAKRWNPSVPQSVENIILKATAKDPFHRYETAEDMEADIKTAFDADRL NEKRFTIQEDEEMTKAIPIIKDEELAKAAGEKEAEVTTAQENKTKKNGKRKKWPWVLL TICLVFITAGILAVTVFPSLFMPKDVKIPDVSGMEYEKAAGLLEKEGLQVDSEVLEIS DEKIEEGLMVKTDPKADTTVKEGATVTLYKSTGKAKTEIGDVTGQTVDQAKKALKDQG FNHVTVNEVNDEKNAGTVIDQNPSAGTELVPSEDQVKLTVSIGPEDITLRDLKTYSKE AASGYLEDNGLKLVEKEAYSDDVPEGQVVKQKPAAGTAVKPGNEVEVTFSLGPEKKPA KTVKEKVKIPYEPENEGDELQVQIAVDDADHSISDTYEEFKIKEPTERTIELKIEPGQ KGYYQVMVNNKVVSYKTIEYPKDE*" /label="prkC CDS" gene 1524963..1526909 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /label="prkC gene" promotor_-35 1526818..1526824 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1526838..1526856 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1526854 /Source="Nicolas_upshifts" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1526924..1527820 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome biogenesis" /protein_id="NP_389460.1" /db_xref="EnsemblGenomes-Gn:BSU15780" /db_xref="EnsemblGenomes-Tr:CAB13451" /db_xref="GOA:O34530" /db_xref="InterPro:IPR004881" /db_xref="InterPro:IPR010914" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="InterPro:IPR031944" /db_xref="PDB:1T9H" /db_xref="SubtiList:BG13392" /db_xref="UniProtKB/Swiss-Prot:O34530" /translation="MPEGKIIKALSGFYYVLDESEDSDKVIQCRGRGIFRKNKITPLV GDYVVYQAENDKEGYLMEIKERTNELIRPPICNVDQAVLVFSAVQPSFSTALLDRFLV LVEANDIQPIICITKMDLIEDQDTEDTIQAYAEDYRNIGYDVYLTSSKDQDSLADIIP HFQDKTTVFAGQSGVGKSSLLNAISPELGLRTNEISEHLGRGKHTTRHVELIHTSGGL VADTPGFSSLEFTDIEEEELGYTFPDIREKSSSCKFRGCLHLKEPKCAVKQAVEDGEL KQYRYDHYVEFMTEIKDRKPRY*" /label="rsgA CDS" gene 1526924..1527820 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /label="rsgA gene" CDS 1527825..1528478 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /EC_number="5.1.3.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 973353, 15755726, 16489742, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribulose-5-phosphate 3-epimerase" /protein_id="NP_389461.1" /db_xref="EnsemblGenomes-Gn:BSU15790" /db_xref="EnsemblGenomes-Tr:CAB13452" /db_xref="GOA:O34557" /db_xref="InterPro:IPR000056" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR026019" /db_xref="SubtiList:BG13393" /db_xref="UniProtKB/Swiss-Prot:O34557" /translation="MIKVAPSILSADFAALGNEIKDVEKGGADCIHIDVMDGHFVPNI TIGPLIVEAVRPVTDLPLDVHLMIEEPDRYIPAFAKAGADILSVHAEACPHLHRTIQL IKEQGVKAGVVLNPHTPVQVIEHVFDDLDLVLLMTVNPGFGGQKFIHSVLPKIKEVKR MADEKGKKDLLIEVDGGVNKETAPLVIEAGANLLVAGSAVYGQSDRKKAISEIRGSK* " /label="rpe CDS" gene 1527825..1528478 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /label="rpe gene" promotor_-35 1528476..1528485 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-35" promotor_-10 1528499..1528518 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-10" upshifts 1528504 /Source="Nicolas_upshifts" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="upshifts" CDS 1528551..1529195 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /EC_number="2.7.6.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14567704, 15150256, 16291685, 19490098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine pyrophosphokinase" /protein_id="NP_389462.1" /db_xref="EnsemblGenomes-Gn:BSU15800" /db_xref="EnsemblGenomes-Tr:CAB13453" /db_xref="GOA:O34664" /db_xref="InterPro:IPR006282" /db_xref="InterPro:IPR007371" /db_xref="InterPro:IPR007373" /db_xref="InterPro:IPR036371" /db_xref="InterPro:IPR036759" /db_xref="PDB:3LM8" /db_xref="SubtiList:BG13394" /db_xref="UniProtKB/Swiss-Prot:O34664" /translation="MKTINIVAGGPKNLIPDLTGYTDEHTLWIGVDKGTVTLLDAGII PVEAFGDFDSITEQERRRIEKAAPALHVYQAEKDQTDLDLALDWALEKQPDIIQIFGI TGGRADHFLGNIQLLYKGVKTNIKIRLIDKQNHIQMFPPGEYDIEKDENKRYISFIPF SEDIHELTLTGFKYPLNNCHITLGSTLCISNELIHSRGTFSFAKGILIMIRSTD*" /label="thiN CDS" gene 1528551..1529195 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /label="thiN gene" promotor_-35 1528956..1528962 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-35" upshifts 1528973 /Source="Nicolas_upshifts" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="upshifts" promotor_-10 1528977..1528995 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-10" promotor_-35 1529086..1529091 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1529107..1529125 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1529120 /Source="Nicolas_upshifts" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="upshifts" S_feature 1529196..1529266 /Source="Nicolas_S_feature" /locus_tag="new_1655375_1655445" /HighExp="S4, S5, S7, S8, S6, S3, B36, G/S, B60, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigB, SigA, SigA" /TUshortPSig="0.977, 0.548, 0.973, 1, 0.994" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S573" CDS 1529267..1529347 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for normal spore cortex and coatsynthesis (stage V sporulation)" /protein_id="NP_389463.1" /db_xref="EnsemblGenomes-Gn:BSU15810" /db_xref="EnsemblGenomes-Tr:CAB13454" /db_xref="GOA:P37817" /db_xref="InterPro:IPR012609" /db_xref="PDB:2MVH" /db_xref="PDB:2MVJ" /db_xref="SubtiList:BG10776" /db_xref="UniProtKB/Swiss-Prot:P37817" /translation="MKFYTIKLPKFLGGIVRAMLGSFRKD*" /label="spoVM CDS" gene 1529267..1529347 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /label="spoVM gene" downshifts 1529362 /Source="Nicolas_upshifts" /id="D879" /incds=0 /nref=178 /ntot=258 /MaxReadThrough="4.05442" /MaxDrop="7.745" /score="7.47691609" /energy="-16.9" /TU="U1301,U1302" /idTUdmin="U1295" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1529407..1529779 /Source="Nicolas_S_feature" /locus_tag="new_1655586_1655958" /HighExp="S4, S5, T5.0H, S3, S6, S8, S7, T4.0H, LoTm, T3.30H" /AntisenseName="rpmB" /AntisenseCor="-0.40376097579549802" /AntisenseRegPval="-11.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.977, 0.548" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S574" CDS complement(1529420..1529608) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8722036; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L28" /protein_id="NP_389464.1" /db_xref="EnsemblGenomes-Gn:BSU15820" /db_xref="EnsemblGenomes-Tr:CAB13455" /db_xref="GOA:P37807" /db_xref="InterPro:IPR001383" /db_xref="InterPro:IPR026569" /db_xref="InterPro:IPR034704" /db_xref="InterPro:IPR037147" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10777" /db_xref="UniProtKB/Swiss-Prot:P37807" /translation="MARKCVITGKKTTAGNNRSHAMNASKRTWGANLQKVRILVNGKP KKVYVSARALKSGKVERV*" /label="rpmB CDS" gene complement(1529420..1529608) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /label="rpmB gene" downshifts complement(1529436) /Source="Nicolas_upshifts" /id="D880" /incds=0 /nref=216 /ntot=298 /MaxReadThrough="2.59598" /MaxDrop="7.48719" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" downshifts complement(1529482) /Source="Nicolas_upshifts" /id="D881" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="7.6779" /MaxDrop="3.1786" /score="15.2403969" /energy="-14.3" /TU="U1303" /idTUdmin="U1303" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(1529609..1529701) /Source="Nicolas_S_feature" /locus_tag="new_1655788_1655880_c" /HighExp="HPh, LPh, HiOs, LBGexp, aero, G180, GM 15, dia0, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S575" promotor_-10 complement(1529683..1529702) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1529701) /Source="Nicolas_upshifts" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1529718..1529721) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1529752..1529759 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1529774..1529792 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1529781 /Source="Nicolas_upshifts" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="upshifts" promotor_-35 1529820..1529823 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1529838..1529857 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1529846 /Source="Nicolas_upshifts" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="upshifts" CDS 1529885..1530247 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 17114254, 24178028, 28579978; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor involved in malonyl-CoA synthesis" /protein_id="NP_389465.1" /db_xref="EnsemblGenomes-Gn:BSU15830" /db_xref="EnsemblGenomes-Tr:CAB13456" /db_xref="InterPro:IPR005531" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG13395" /db_xref="UniProtKB/Swiss-Prot:O34318" /translation="MSIELRTKYGQIDISNEVIAMVAGGAAVDCYGIVGMASKNQIKD GLTEILRKENFSRGVQVRQEGEQIHIDMYIIVSYGTKISEVAHNVQTKVKYTVNQTIG LAVDSVNIYVQGVRVTNP*" /label="yloU CDS" gene 1529885..1530247 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /label="yloU gene" downshifts complement(1530098) /Source="Nicolas_upshifts" /id="D882" /incds=1 /nref=1 /ntot=143 /MaxReadThrough="1.75412" /MaxDrop="2.71497" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS 1530263..1531924 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16647083, 22333191, 22517742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme structurally related to dihydroxyacetone/glyceraldehyde kinase" /protein_id="NP_389466.1" /db_xref="EnsemblGenomes-Gn:BSU15840" /db_xref="EnsemblGenomes-Tr:CAB13457" /db_xref="GOA:O34751" /db_xref="InterPro:IPR004007" /db_xref="InterPro:IPR019986" /db_xref="InterPro:IPR033470" /db_xref="InterPro:IPR036117" /db_xref="SubtiList:BG13396" /db_xref="UniProtKB/Swiss-Prot:O34751" /translation="MSIRTLDGRTFAEMILAGAQNLSQNASAVDALNVFPVPDGDTGT NMNLSMTSGAREVEQMDTDDIGKVGSALSKGLLMGARGNSGVILSQLFRGFSKNIETK KEINALEFAAALQAGVDMAYKAVMKPVEGTILTVAKDAAKKAMILAEKETDITALMTA VTEEAEASLNRTPELLPVLKEVGVVDSGGKGLLCVYEGFLASLKGETVPQKAVLPSLD DMVSAEHHKSAQSMMNTEDIEFGFCTEVMVRLDQTKREFDEGTFRQDLSQFGDSLLVI ADESLAKVHIHAEEPGNVLNYAQHYGELIKIKIENMREQHTSIISQESKPADNETPPA KQPYGIVTVAMGEGIADLFKSIGASVVIEGGQTMNPSTEDIVDAVKSVNADTVFILPN NSNIIMAANQAASVVDEQVFVIPAKTVPQGMSALLAFNPDQEAEANEANMLSAIQQVK SGQVTFSVRDTHIDGKDIKKGDFMGILNGTIIGTSENQLSAAKMLLSEMIGEDDEIVT ILYGEDASQEEAEQLEAFLSEKYEEIEVEIHNGKQPLYSYIVSAE*" /label="yloV CDS" gene 1530263..1531924 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /label="yloV gene" S_feature 1531925..1532014 /Source="Nicolas_S_feature" /locus_tag="new_1658104_1658193" /HighExp="G135, G180, G150, LBGexp, Oxctl, Paraq, dia0, LPh, Lbexp, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37023200000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.991, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S576" promotor_-35 1531987..1531994 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-35" promotor_-10 1532008..1532027 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-10" upshifts 1532016 /Source="Nicolas_upshifts" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="upshifts" CDS 1532063..1532725 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8385012, 9244285, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385012, 9244285, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (beta chain)" /protein_id="NP_389467.1" /db_xref="EnsemblGenomes-Gn:BSU15850" /db_xref="EnsemblGenomes-Tr:CAB13458" /db_xref="GOA:O34635" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004643" /db_xref="InterPro:IPR005131" /db_xref="InterPro:IPR029009" /db_xref="SubtiList:BG13397" /db_xref="UniProtKB/Swiss-Prot:O34635" /translation="MKYRSVFDIIGPVMIGPSSSHTAGAARIGRVARSLFGREPERII VSFYGSFAETYKGHGTDVAIIGGLLDFDTFDERIKTAIQIAEAKGIDIEFRVEDAVPV HPNTAKITISDEKGELELTGISIGGGKIEITELNGFELRLSGNHPAILVVHNDKFGTI AGVANVLAKFSINVGHMEVARKDIGQLALMTIEVDQNIDDHILDELSKLPNIIQVTKI AD*" /label="sdaAB CDS" gene 1532063..1532725 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /label="sdaAB gene" CDS 1532751..1533653 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2504697, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2504697, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (alpha chain)" /protein_id="NP_389468.1" /db_xref="EnsemblGenomes-Gn:BSU15860" /db_xref="EnsemblGenomes-Tr:CAB13459" /db_xref="GOA:O34607" /db_xref="InterPro:IPR004642" /db_xref="InterPro:IPR005130" /db_xref="SubtiList:BG13398" /db_xref="UniProtKB/Swiss-Prot:O34607" /translation="MFRNVKELIEITKEKQILISDVMIAQEMEVTEKTKEDIFQQMDH NLSVMEAAVQKGLEGVTSQTGLTGGDAVKLQAYIRSGKSLSGPLILDAVSKAVATNEV NAAMGTICATPTAGSAGVVPGTLFAVKEKLNPTREQMIRFLFTAGAFGFVVANNASIS GAAGGCQAEVGSASGMAAAAIVEMAGGTPEQSAEAMAITLKNMLGLVCDPVAGLVEVP CVKRNAMGASNAMIAADMALAGITSRIPCDEVIDAMYKIGQTMPTALRETGQGGLAAT PTGRELEKKIFGGALGSRETTSAN*" /label="sdaAA CDS" gene 1532751..1533653 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /label="sdaAA gene" CDS 1533631..1535679 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branch migrating ATP-dependent DNA helicase involved in DNA recombination and repair" /protein_id="NP_389469.1" /db_xref="EnsemblGenomes-Gn:BSU15870" /db_xref="EnsemblGenomes-Tr:CAB13460" /db_xref="GOA:O34942" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR004609" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033454" /db_xref="SubtiList:BG13399" /db_xref="UniProtKB/Swiss-Prot:O34942" /translation="MKQHQQTSIANIKGIGPETEKTLNELGIYDISDLLNYFPYRYDD YELRDLEEVKHDERVTVEGKVHSEPSLTYYGKKRNRLTFRLLVGHYLITAVCFNRPYL KKKLSLGSVVTVSGKWDKHRQTISVQELKNGPHQEDKSIEPVYSVKENVTVKMMRRFI QQALTQYADSLPDPLPEKLRKSYKLPDYYQALKAMHQPETREALKLARRRFVYEEFLL FQLKMQAFRKAEREQTQGIRQRFSNEELMRFIKSLPFPLTNAQSRVLREITADMSSPY RMNRLLQGDVGSGKTAVAAIALYAAILSGYQGALMVPTEILAEQHADSLVSLFEKWDV SVALLTSSVKGKRRKELLERLAAGEIDILVGTHALIQDEVEFKALSLVITDEQHRFGV EQRKKLRNKGQDPDVLFMTATPIPRTLAITVFGEMDVSVIDEMPAGRKRIETYWVKHD MLDRILAFVEKELKQGRQAYIICPLIEESDKLDVQNAIDVYNMLSDIFRGKWNVGLMH GKLHSDEKDQVMREFSANHCQILVSTTVVEVGVNVPNATIMVIYDADRFGLSQLHQLR GRVGRGEHQSFCILMADPKSETGKERMRIMSETNDGFELSEKDLELRGPGDFFGKKQS GMPEFKVADMVHDYRALETARQDAANLVASDAFWKEPEYAVLRDELLKSGVMDGEKLS *" /label="recG CDS" gene 1533631..1535679 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /label="recG gene" promotor_-35 1535715..1535722 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1535737..1535756 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1535743 /Source="Nicolas_upshifts" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1535788..1536354 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12737802, 17962296, 20201588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12737802, 17962296, 20201588, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription factor controlling fatty acid and phospholipid metabolism (FapR-malonyl-Coa)" /protein_id="NP_389470.1" /db_xref="EnsemblGenomes-Gn:BSU15880" /db_xref="EnsemblGenomes-Tr:CAB13461" /db_xref="GOA:O34835" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR017275" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="PDB:2F3X" /db_xref="PDB:2F41" /db_xref="SubtiList:BG13400" /db_xref="UniProtKB/Swiss-Prot:O34835" /translation="MRRNKRERQELLQQTIQATPFITDEELAGKFGVSIQTIRLDRLE LSIPELRERIKNVAEKTLEDEVKSLSLDEVIGEIIDLELDDQAISILEIKQEHVFSRN QIARGHHLFAQANSLAVAVIDDELALTASADIRFTRQVKQGERVVAKAKVTAVEKEKG RTVVEVNSYVGEEIVFSGRFDMYRSKHS*" /label="fapR CDS" gene 1535788..1536354 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /label="fapR gene" CDS 1536368..1537369 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphate:acyl-ACP acyltransferase" /protein_id="NP_389471.1" /db_xref="EnsemblGenomes-Gn:BSU15890" /db_xref="EnsemblGenomes-Tr:CAB13462" /db_xref="GOA:P71018" /db_xref="InterPro:IPR003664" /db_xref="InterPro:IPR012281" /db_xref="PDB:1VI1" /db_xref="SubtiList:BG11843" /db_xref="UniProtKB/Swiss-Prot:P71018" /translation="MRIAVDAMGGDHAPKAVIDGVIKGIEAFDDLHITLVGDKTTIES HLTTTSDRITVLHADEVIEPTDEPVRAVRRKKNSSMVLMAQEVAENRADACISAGNTG ALMTAGLFIVGRIKGIDRPALAPTLPTVSGDGFLLLDVGANVDAKPEHLVQYAIMGSV YSQQVRGVTSPRVGLLNVGTEDKKGNELTKQTFQILKETANINFIGNVEARDLLDDVA DVVVTDGFTGNVTLKTLEGSALSIFKMMRDVMTSTLTSKLAAAVLKPKLKEMKMKMEY SNYGGASLFGLKAPVIKAHGSSDSNAVFHAIRQAREMVSQNVAALIQEEVKEEKTDE* " /label="plsX CDS" gene 1536368..1537369 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /label="plsX gene" CDS 1537388..1538341 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /EC_number="2.3.1.39" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586097, 19850612" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586097, 19850612; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malonyl CoA:acyl carrier protein transacylase" /protein_id="NP_389472.1" /db_xref="EnsemblGenomes-Gn:BSU15900" /db_xref="EnsemblGenomes-Tr:CAB13463" /db_xref="GOA:P71019" /db_xref="InterPro:IPR004410" /db_xref="InterPro:IPR014043" /db_xref="InterPro:IPR016035" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR020801" /db_xref="InterPro:IPR024925" /db_xref="SubtiList:BG11836" /db_xref="UniProtKB/Swiss-Prot:P71019" /translation="MSKIAFLFPGQGSQFIGMGKELYEQVPAAKRLFDEADETLETKL SSLIFEGDAEELTLTYNAQPALLTTSIAVLEKFKESGITPDFTAGHSLGEYSALVAAG ALSFKDAVYTVRKRGEFMNEAVPAGEGAMAAILGMDAEALKQVTDKVTEEGNLVQLAN LNCPGQIVISGTAKGVELASELAKENGAKRAIPLEVSGPFHSELMKPAAEKLKEVLDA CDIKDADVPVISNVSADVMTEKADIKEKLIEQLYSPVRFEESINKLIAEGVTTFIEIG PGKVLSGLVKKVNRRLKTIAVSDPETIELAIQTLKEENDNA*" /label="fabD CDS" gene 1537388..1538341 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /label="fabD gene" CDS 1538334..1539074 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /EC_number="1.1.1.100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12655455, 12682299, 19850612, 28126742" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12655455, 12682299, 19850612, 28126742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein reductase" /protein_id="NP_389473.1" /db_xref="EnsemblGenomes-Gn:BSU15910" /db_xref="EnsemblGenomes-Tr:CAB13464" /db_xref="GOA:P51831" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011284" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11535" /db_xref="UniProtKB/Swiss-Prot:P51831" /translation="MLNDKTAIVTGASRGIGRSIALDLAKSGANVVVNYSGNEAKANE VVDEIKSMGRKAIAVKADVSNPEDVQNMIKETLSVFSTIDILVNNAGITRDNLIMRMK EDEWDDVININLKGVFNCTKAVTRQMMKQRSGRIINVSSIVGVSGNPGQANYVAAKAG VIGLTKSSAKELASRNITVNAIAPGFISTDMTDKLAKDVQDEMLKQIPLARFGEPSDV SSVVTFLASEGARYMTGQTLHIDGGMVM*" /label="fabG CDS" gene 1538334..1539074 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /label="fabG gene" promotor_-35 1539105..1539109 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1539125..1539144 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1539130 /Source="Nicolas_upshifts" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1539158..1539391 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 19850612, 27467752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 19850612, 27467752; Product type c: carrier" /codon_start=1 /transl_table=11 /product="acyl carrier protein" /protein_id="NP_389474.1" /db_xref="EnsemblGenomes-Gn:BSU15920" /db_xref="EnsemblGenomes-Tr:CAB13465" /db_xref="GOA:P80643" /db_xref="InterPro:IPR003231" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:1F80" /db_xref="PDB:1HY8" /db_xref="PDB:2X2B" /db_xref="SubtiList:BG11536" /db_xref="UniProtKB/Swiss-Prot:P80643" /translation="MADTLERVTKIIVDRLGVDEADVKLEASFKEDLGADSLDVVELV MELEDEFDMEISDEDAEKIATVGDAVNYIQNQQ*" /label="acpA CDS" gene 1539158..1539391 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /label="acpA gene" downshifts 1539372 /Source="Nicolas_upshifts" /id="D883" /incds=0 /nref=22 /ntot=197 /MaxReadThrough="8.12206" /MaxDrop="4.1545" /score="-8.42930766" /energy="-17.4" /TU="U1306,U1307,U1308" /idTUdmin="U1306" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" promotor_no_box 1539400..1539500 /Source="Nicolas_upshift_promotors" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 1539460..1539530 /Source="Nicolas_S_feature" /locus_tag="new_1665639_1665709" /HighExp="LBGstat, dia5, Cold, LBGtran, C30, Diami, G135, LBGexp, G/S, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA, SigA" /TUshortPSig="0.031, 1, 1, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="0.991, 0.991" /label="S577" upshifts 1539460 /Source="Nicolas_upshifts" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1539531..1540280 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /EC_number="3.1.26.3" /experiment="publication(s) with functional evidences, PMID:11123676, 12682299, 16179796, 22412379, 23300471, 26883633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11123676, 12682299, 16179796, 22412379, 23300471, 26883633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease III" /protein_id="NP_389475.1" /db_xref="EnsemblGenomes-Gn:BSU15930" /db_xref="EnsemblGenomes-Tr:CAB13466" /db_xref="GOA:P51833" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR011907" /db_xref="InterPro:IPR014720" /db_xref="InterPro:IPR036389" /db_xref="SubtiList:BG11537" /db_xref="UniProtKB/Swiss-Prot:P51833" /translation="MSKHSHYKDKKKFYKKVEQFKEFQERISVHFQNEKLLYQAFTHS SYVNEHRKKPYEDNERLEFLGDAVLELTISRFLFAKYPAMSEGDLTKLRAAIVCEPSL VSLAHELSFGDLVLLGKGEEMTGGRKRPALLADVFEAFIGALYLDQGLEPVESFLKVY VFPKINDGAFSHVMDFKSQLQEYVQRDGKGSLEYKISNEKGPAHNREFEAIVSLKGEP LGVGNGRSKKEAEQHAAQEALAKLQKHHTKQ*" /label="rnc CDS" gene 1539531..1540280 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /label="rnc gene" downshifts 1540252 /Source="Nicolas_upshifts" /id="D884" /incds=0 /nref=78 /ntot=211 /MaxReadThrough="6.42554" /MaxDrop="5.70849" /score="-8.42930766" /energy="-17.4" /TU="U1307,U1308,U1309" /idTUdmin="U1306" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1540322..1540328 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1540340..1540359 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1540362 /Source="Nicolas_upshifts" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1540381..1543941 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation SMC ATPase" /protein_id="NP_389476.2" /db_xref="EnsemblGenomes-Gn:BSU15940" /db_xref="EnsemblGenomes-Tr:CAB13467" /db_xref="GOA:P51834" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR010935" /db_xref="InterPro:IPR011890" /db_xref="InterPro:IPR024704" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036277" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5NMO" /db_xref="PDB:5NNV" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG11538" /db_xref="UniProtKB/Swiss-Prot:P51834" /translation="MFLKRLDVIGFKSFAERISVDFVKGVTAVVGPNGSGKSNITDAI RWVLGEQSARSLRGGKMEDIIFAGSDSRKRLNLAEVTLTLDNDDHFLPIDFHEVSVTR RVYRSGESEFLINNQPCRLKDIIDLFMDSGLGKEAFSIISQGKVEEILSSKAEDRRSI FEEAAGVLKYKTRKKKAENKLFETQDNLNRVEDILHELEGQVEPLKIQASIAKDYLEK KKELEHVEIALTAYDIEELHGKWSTLKEKVQMAKEEELAESSAISAKEAKIEDTRDKI QALDESVDELQQVLLVTSEELEKLEGRKEVLKERKKNAVQNQEQLEEAIVQFQQKETV LKEELSKQEAVFETLQAEVKQLRAQVKEKQQALSLHNENVEEKIEQLKSDYFELLNSQ ASIRNELQLLDDQMSQSAVTLQRLADNNEKHLQERHDISARKAACETEFARIEQEIHS QVGAYRDMQTKYEQKKRQYEKNESALYQAYQYVQQARSKKDMLETMQGDFSGFYQGVK EVLKAKERLGGIRGAVLELISTEQKYETAIEIALGASAQHVVTDDEQSARKAIQYLKQ NSFGRATFLPLSVIRDRQLQSRDAETAARHSSFLGVASELVTFDPAYRSVIQNLLGTV LITEDLKGANELAKLLGHRYRIVTLEGDVVNPGGSMTGGAVKKKNNSLLGRSRELEDV TKRLAEMEEKTALLEQEVKTLKHSIQDMEKKLADLRETGEGLRLKQQDVKGQLYELQV AEKNINTHLELYDQEKSALSESDEERKVRKRKLEEELSAVSEKMKQLEEDIDRLTKQK QTQSSTKESLSNELTELKIAAAKKEQACKGEEDNLARLKKELTETELALKEAKEDLSF LTSEMSSSTSGEEKLEEAAKHKLNDKTKTIELIALRRDQRIKLQHGLDTYERELKEMK RLYKQKTTLLKDEEVKLGRMEVELDNLLQYLREEYSLSFEGAKEKYQLETDPEEARKR VKLIKLAIEELGTVNLGSIDEFERVNERYKFLSEQKEDLTEAKNTLFQVIEEMDEEMT KRFNDTFVQIRSHFDQVFRSLFGGGRAELRLTDPNDLLHSGVEIIAQPPGKKLQNLNL LSGGERALTAIALLFSILKVRPVPFCVLDEVEAALDEANVFRFAQYLKKYSSDTQFIV ITHRKGTMEEADVLYGVTMQESGVSKVISVKLEETKEFVQ*" /label="smc CDS" gene 1540381..1543941 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /label="smc gene" S_feature complement(1543875..1544945) /Source="Nicolas_S_feature" /locus_tag="new_1670054_1671124_c" /HighExp="Cold, C30, Gly, T0.30H, Pyr, T-4.40H, G135, Lbstat, Fru, T-5.40H" /AntisenseName="ftsY" /AntisenseCor="-3.7172405649441298E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S578" CDS 1543961..1544950 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal recognition particle (docking protein)" /protein_id="NP_389477.1" /db_xref="EnsemblGenomes-Gn:BSU15950" /db_xref="EnsemblGenomes-Tr:CAB13468" /db_xref="GOA:P51835" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004390" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036225" /db_xref="SubtiList:BG11539" /db_xref="UniProtKB/Swiss-Prot:P51835" /translation="MSFFKKLKEKITKQTDSVSEKFKDGLEKTRNSFQNKVNDLVSRY RKVDEDFFEELEEVLISADVGFTTVMELIDELKKEVKRRNIQDPKEVQSVISEKLVEI YNSGDEQISELNIQDGRLNVILLVGVNGVGKTTTIGKLAHKMKQEGKSVVLAAGDTFR AGAIEQLEVWGERTGVPVIKQTAGSDPAAVIYDAVHAAKARNADVLICDTAGRLQNKV NLMKELEKVKRVIEREVPEAPHEVLLALDATTGQNAMAQAKEFSKATNVTGIALTKLD GTAKGGIVLAIRNELHIPVKLVGLGEKVDDLQEFDPESYVYGLFSDLVEKADD*" /label="ftsY CDS" gene 1543961..1544950 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /label="ftsY gene" downshifts 1544937 /Source="Nicolas_upshifts" /id="D885" /incds=0 /nref=220 /ntot=261 /MaxReadThrough="2.98458" /MaxDrop="6.84303" /score="49.5808683" /energy="-14.4" /TU="NA" /idTUdmin="U1307" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1544987..1545472) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535, 22287527" /codon_start=1 /transl_table=11 /product="conserved exported protein of unknown function" /protein_id="NP_389478.1" /db_xref="EnsemblGenomes-Gn:BSU15960" /db_xref="EnsemblGenomes-Tr:CAB13469" /db_xref="GOA:O31737" /db_xref="InterPro:IPR008969" /db_xref="InterPro:IPR008979" /db_xref="SubtiList:BG13401" /db_xref="UniProtKB/Swiss-Prot:O31737" /translation="MKKIGLLFMLCLAALFTIGFPAQQADAAEAPYKASITNISTDGG VYGKINYGQGQYWRVKYNITVSGKLLDQNGQPVPNAPVRFEADTKVGNTTQTASGTTD ANGTFEVPMYLGPAAGYYTYYTSVSVHYYDIIPFRVFSGESRLVSTDNSLYHFAYQVR R*" /label="ylqB CDS" gene complement(1544987..1545472) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /label="ylqB gene" downshifts complement(1544990) /Source="Nicolas_upshifts" /id="D886" /incds=0 /nref=139 /ntot=244 /MaxReadThrough="6.77251" /MaxDrop="6.10895" /score="32.8428224" /energy="-14.4" /TU="U1311" /idTUdmin="U1311" /TUdmin="-1076" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1545494..1545512) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1545510) /Source="Nicolas_upshifts" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1545526..1545533) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1545575..1545581 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1545596..1545615 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1545598 /Source="Nicolas_upshifts" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1545649..1545981 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11274114, 24659773; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the signal recognition particle (SRP) protein-targeting pathway" /protein_id="NP_389479.1" /db_xref="EnsemblGenomes-Gn:BSU15970" /db_xref="EnsemblGenomes-Tr:CAB13470" /db_xref="GOA:P37104" /db_xref="InterPro:IPR007394" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10829" /db_xref="UniProtKB/Swiss-Prot:P37104" /translation="MSLEKTTRMNYLFDFYQSLLTSKQKSYMSLYYLDDFSLGEIAEE YEVSRQAVYDNIKRTEAMLEQYEEKLLLLKKFQERKEMFNKLKELASGSKEEEEITAL IEALEKLD*" /label="ylxM CDS" gene 1545649..1545981 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /label="ylxM gene" downshifts complement(1545652) /Source="Nicolas_upshifts" /id="D887" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="1.40385" /MaxDrop="4.6092" /score="32.8428224" /energy="-14.4" /TU="NA" /idTUdmin="U1311" /TUdmin="-1738" /isTUend="FALSE" /label="downshifts" CDS 1545995..1547335 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="signal recognition particle-like (SRP) GTPase" /protein_id="NP_389480.1" /db_xref="EnsemblGenomes-Gn:BSU15980" /db_xref="EnsemblGenomes-Tr:CAB13471" /db_xref="GOA:P37105" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004125" /db_xref="InterPro:IPR004780" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR022941" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036891" /db_xref="PDB:4UE4" /db_xref="SubtiList:BG10830" /db_xref="UniProtKB/Swiss-Prot:P37105" /translation="MAFEGLADRLQQTISKIRGKGKVSEQDVKEMMREVRLALLEADV NFKVVKDFVKKVSERAVGQDVMKSLTPGQQVIKVVQEELTELMGGEESKIAVAKRPPT VIMMVGLQGAGKTTTSGKLANLLRKKHNRKPMLVAADIYRPAAIKQLETLGKQLDMPV FSLGDQVSPVEIAKQAIEKAKEEHYDYVILDTAGRLHIDHELMDELTNVKEIANPEEI FLVVDSMTGQDAVNVAKSFNEQLGLTGVVLTKLDGDTRGGAALSIRAVTNTPIKFAGL GEKLDALEPFHPERMASRILGMGDVLTLIEKAQASVDEDKAKELEQKMRTMSFTLDDF LEQLGQVRNMGPLDELLQMMPGAGKMKGLKNIQVDEKQLNHVEAIIKSMTVLEKEQPD IINASRRKRIAKGSGTSVQEVNRLLKQFDEMKKMMKQMTNMSKGKKKGFKLPFM*" /label="ffh CDS" gene 1545995..1547335 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /label="ffh gene" S_feature 1547336..1547440 /Source="Nicolas_S_feature" /locus_tag="new_1673515_1673619" /HighExp="Cold, G135, C30, G180, LPhT, HPh, Paraq, LPh, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S579" CDS 1547441..1547713 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6419023, 12682299, 20034956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6419023, 12682299, 20034956; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S16 (BS17)" /protein_id="NP_389481.1" /db_xref="EnsemblGenomes-Gn:BSU15990" /db_xref="EnsemblGenomes-Tr:CAB13472" /db_xref="GOA:P21474" /db_xref="InterPro:IPR000307" /db_xref="InterPro:IPR020592" /db_xref="InterPro:IPR023803" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10831" /db_xref="UniProtKB/Swiss-Prot:P21474" /translation="MAVKIRLKRMGAKKSPFYRIVVADSRSPRDGRFIETVGTYNPVA KPAEVKIDEELALKWLQTGAKPSDTVRNLFSSQGIMEKFHNAKQGK*" /label="rpsP CDS" gene 1547441..1547713 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /label="rpsP gene" CDS 1547713..1547958 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735, 26483775; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_389482.1" /db_xref="EnsemblGenomes-Gn:BSU16000" /db_xref="EnsemblGenomes-Tr:CAB13473" /db_xref="GOA:O31738" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020627" /db_xref="SubtiList:BG13402" /db_xref="UniProtKB/Swiss-Prot:O31738" /translation="MTDQHLEDLIVHIVTPLVDHPDDIRVIREETDQKIALRLSVHKS DTGKVIGKQGRTAKAIRTAVFAAGVQSSKKVQFEIFD*" /label="ylqC CDS" gene 1547713..1547958 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /label="ylqC gene" downshifts 1547930 /Source="Nicolas_upshifts" /id="D888" /incds=0 /nref=41 /ntot=178 /MaxReadThrough="6.57974" /MaxDrop="4.803" /score="-7.01631592" /energy="-5.6" /TU="U1312" /idTUdmin="U1312" /TUdmin="-1804" /isTUend="FALSE" /label="downshifts" S_feature 1547975..1548079 /Source="Nicolas_S_feature" /locus_tag="new_1674154_1674258" /HighExp="G180, Oxctl, G150, G135, Paraq, LBGexp, H2O2, HPh, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S580" CDS 1548080..1548466 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389483.1" /db_xref="EnsemblGenomes-Gn:BSU16010" /db_xref="EnsemblGenomes-Tr:CAB13474" /db_xref="InterPro:IPR021297" /db_xref="SubtiList:BG13403" /db_xref="UniProtKB/Swiss-Prot:O31739" /translation="MQIIHRVAVMQVLTERSKEKLLASFAEKKQMLERECSQLYFQLR KHEKEQQNPNMIEQFKKAIEKRKDDIKIIDFQIAQVHTLPLGSELKEKEVDALLTIEA GDDWHEKTAANTIVIKDGKVIEIRQR*" /label="ylqD CDS" gene 1548080..1548466 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /label="ylqD gene" CDS 1548471..1548995 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15496525, 16014871, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="16S rRNA processing protein" /protein_id="NP_389484.1" /db_xref="EnsemblGenomes-Gn:BSU16020" /db_xref="EnsemblGenomes-Tr:CAB13475" /db_xref="GOA:O31740" /db_xref="InterPro:IPR002676" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR011961" /db_xref="InterPro:IPR027275" /db_xref="InterPro:IPR036976" /db_xref="SubtiList:BG13404" /db_xref="UniProtKB/Swiss-Prot:O31740" /translation="MTKRWFNVGKIVNTHGIKGEVRVISKTDFAEERYKPGNTLYLFM DGRNEPVEVTVNTHRLHKQFHLLQFKERQNLNEVEELKNAIIKVPEEELGELNEGEFY FHEIIGCEVFTEEGELIGKVKEILTPGANDVWVIGRKGKKDALIPYIESVVKHIDVRE KKIEIELMEGLIDE*" /label="rimM CDS" gene 1548471..1548995 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /label="rimM gene" CDS 1548992..1549723 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /EC_number="2.1.1.228" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094308, 11532950, 12682299, 12773376, 15060037, 27881678, 28601227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(m1G37)methyltransferase" /protein_id="NP_389485.1" /db_xref="EnsemblGenomes-Gn:BSU16030" /db_xref="EnsemblGenomes-Tr:CAB13476" /db_xref="GOA:O31741" /db_xref="InterPro:IPR002649" /db_xref="InterPro:IPR016009" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG12687" /db_xref="UniProtKB/Swiss-Prot:O31741" /translation="MKIDFLTLFPEMFEGVLGSSILQKAQEKDAVQFQVVNFREYSDN KHNTVDDYPYGGGAGMVLKPQPVFDAVEDLTSKAAAAPRIILVCPQGERFTQKKAEQL AKEEHLLFICGHYEGYDERIREHLVTDEISIGDFVLTGGELPAMMIADSVVRLLPGVL GKEASHIEDSFSTGLLEHPHYTRPADYKGLKVPETLLSGNHAKIEEWRNKESIRRTYL RRPDLLKDHPLTEQQRKWISEWEKE*" /label="trmD CDS" gene 1548992..1549723 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /label="trmD gene" promotor_-35 1549729..1549736 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1549750..1549769 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1549754 /Source="Nicolas_upshifts" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" misc_RNA 1549802..1549843 /locus_tag="BSU_misc_RNA_30" /product="L19_leader" /label="L19 leader RNA" gene 1549802..1549843 /locus_tag="BSU_misc_RNA_30" /label="gene" CDS 1549863..1550210 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16272117, 27477481; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L19" /protein_id="NP_389486.2" /db_xref="EnsemblGenomes-Gn:BSU16040" /db_xref="EnsemblGenomes-Tr:CAB13477" /db_xref="GOA:O31742" /db_xref="InterPro:IPR001857" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR018257" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12667" /db_xref="UniProtKB/Swiss-Prot:O31742" /translation="MQKLIEDITKEQLRTDLPAFRPGDTLRVHVKVVEGNRERIQIFE GVVIKRRGGGISETFTVRKISYGVGVERTFPVHTPKIAKIEVVRYGKVRRAKLYYLRE LRGKAARIKEIRR*" /label="rplS CDS" gene 1549863..1550210 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /label="rplS gene" downshifts 1550212 /Source="Nicolas_upshifts" /id="D889" /incds=0 /nref=212 /ntot=274 /MaxReadThrough="6.00308" /MaxDrop="9.06015" /score="23.9942041" /energy="-12.6" /TU="U1313" /idTUdmin="U1312" /TUdmin=478 /isTUend="FALSE" /label="downshifts" promotor_-35 1550265..1550271 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1550284..1550352 /Source="Nicolas_S_feature" /locus_tag="new_1676463_1676531" /HighExp="Oxctl, G180, Paraq, G135, H2O2, LBGstat, dia15, G150, HPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.149563" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S581" upshifts 1550284 /Source="Nicolas_upshifts" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1550285..1550304 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1550353..1551201 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome biogenesis GTPase A" /protein_id="NP_389487.1" /db_xref="EnsemblGenomes-Gn:BSU16050" /db_xref="EnsemblGenomes-Tr:CAB13478" /db_xref="GOA:O31743" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016478" /db_xref="InterPro:IPR019991" /db_xref="InterPro:IPR023179" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="PDB:1PUJ" /db_xref="SubtiList:BG13405" /db_xref="UniProtKB/Swiss-Prot:O31743" /translation="MTIQWFPGHMAKARREVTEKLKLIDIVYELVDARIPMSSRNPMI EDILKNKPRIMLLNKADKADAAVTQQWKEHFENQGIRSLSINSVNGQGLNQIVPASKE ILQEKFDRMRAKGVKPRAIRALIIGIPNVGKSTLINRLAKKNIAKTGDRPGITTSQQW VKVGKELELLDTPGILWPKFEDELVGLRLAVTGAIKDSIINLQDVAVFGLRFLEEHYP ERLKERYGLDEIPEDIAELFDAIGEKRGCLMSGGLINYDKTTEVIIRDIRTEKFGRLS FEQPTM*" /label="rbgA CDS" gene 1550353..1551201 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /label="rbgA gene" promotor_-35 1551222..1551229 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1551242..1551260 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1551252 /Source="Nicolas_upshifts" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1551272..1552039 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /EC_number="3.1.26.4" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10094689, 12475934, 23882084, 23937561, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094689, 12475934, 23882084, 23937561, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HII" /protein_id="NP_389488.1" /db_xref="EnsemblGenomes-Gn:BSU16060" /db_xref="EnsemblGenomes-Tr:CAB13479" /db_xref="GOA:O31744" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR022898" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12666" /db_xref="UniProtKB/Swiss-Prot:O31744" /translation="MNTLTVKDIKDRLQEVKDAQDPFIAQCENDPRKSVQTLVEQWLK KQAKEKALKEQWVNMTSYERLARNKGFRLIAGVDEVGRGPLAGPVVASAVILPEECEI LGLTDSKKLSEKKREEYYELIMKEALAVGIGIVEATVIDEINIYEASKMAMVKAIQDL SDTPDYLLVDAMTLPLDTAQASIIKGDAKSVSIAAGACIAKVTRDRMMSAYAETYPMY GFEKNKGYGTKEHLEALAAYGPTELHRKTFAPVQSFR*" /label="rnhB CDS" gene 1551272..1552039 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /label="rnhB gene" CDS 1552071..1553801 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389489.1" /db_xref="EnsemblGenomes-Gn:BSU16070" /db_xref="EnsemblGenomes-Tr:CAB13480" /db_xref="SubtiList:BG13406" /db_xref="UniProtKB/Swiss-Prot:O31745" /translation="MNIRNDVQKALQHLFGRTAVPQETSKVNEALNGEKRLLLGKVLR LLGDQHALIQVGNQTVQGKLETQLRPQAYYWFSYEKKTAEQTGRLQVVQSFDQNPKTI QDAAGKLLNAISVKTSNAALMMTGAMLKSKTPVTENDIKTAVRWMDTLPSQDTKKAVE TVLFALKRDLPIHSEILNGVHAVKSPVPLHQHVSQLLQAIDQNPQQSQMMSKLKEAVT VLLNSEIDVHAERLIDKLISLTDNTKAPSPTNTAGSRELSTPAGSPGKASLPIANHTA EQGSIQEEPVKTAADIPIKEARQLLVKLTESAEKNSLQIVKEAANWIKAAASSGDSKS LAASAVLQAAQVTDQEAEVFLKAVQQTAPHLADKADVLSFLSKVKTAIGARDEVAFIK AFEQGSAVTSGEMQSIKLALSALRASHEVAEPVKQEADQLFHKLNGQLFMQQDHPSYS QIVMSFPMFSKSGVQDMTVLFKGKKEADGKLDPSHCRLLFLLQLDTLKETVVDCLVQQ KVMTITIETDFELQAAIDPMVPALKQGLKEMGYSLSGVNAKKRVHTEEKASIDQYITS ISDQEVDVKI*" /label="ylqG CDS" gene 1552071..1553801 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /label="ylqG gene" upshifts complement(1553308) /Source="Nicolas_upshifts" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1553309..1553328) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1553343..1553350) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1553798..1554079 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative flagellar biosynthesis protein" /protein_id="NP_389490.1" /db_xref="EnsemblGenomes-Gn:BSU16080" /db_xref="EnsemblGenomes-Tr:CAB13481" /db_xref="GOA:O34867" /db_xref="InterPro:IPR004683" /db_xref="InterPro:IPR006135" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13407" /db_xref="UniProtKB/Swiss-Prot:O34867" /translation="MKEQTPIRKAVALHYDEQKDKAPRVIATGKGHVADNIIKEAKKA GVPIQEDRTLVELMRHLTVDDQIPEALYETVAEIFSFIYKLDESVKNKK*" /label="ylqH CDS" gene 1553798..1554079 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /label="ylqH gene" downshifts 1553911 /Source="Nicolas_upshifts" /id="D890" /incds=1 /nref=7 /ntot=136 /MaxReadThrough="4.03339" /MaxDrop="4.52065" /score="-6.81136789" /energy="-9.2" /TU="U1313,U1315" /idTUdmin="U1313" /TUdmin="-267" /isTUend="FALSE" /label="downshifts" S_feature 1554080..1554199 /Source="Nicolas_S_feature" /locus_tag="new_1680259_1680378" /HighExp="Cold, Lbstat, H2O2, Glu, Paraq, Mal, G135, GM 90, Oxctl, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S582" promotor_-35 1554171..1554178 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1554192..1554211 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1554201 /Source="Nicolas_upshifts" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1554252..1555409 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2548486, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (beta subunit)" /protein_id="NP_389491.1" /db_xref="EnsemblGenomes-Gn:BSU16090" /db_xref="EnsemblGenomes-Tr:CAB13482" /db_xref="GOA:P80886" /db_xref="InterPro:IPR005809" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013650" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017866" /db_xref="SubtiList:BG12680" /db_xref="UniProtKB/Swiss-Prot:P80886" /translation="MNIHEYQGKEVLRKYGVSVPEGKVAFTAEEAVESAKSLSSSVYV VKAQIHAGGRGKAGGVKIAKSLDEVKAYAEELLGKTLVTHQTGPDGQVIKRLLIEEGC DIKKEYYIGLVLDRATSRIVLMASEEGGTEIEEVAEKTPEKIKKAVIDPAVGLQGYQA REIAFAINIPKELVGKAAKFMLGLYKAFVEKDCSIAEINPLVVTGDGNVMALDAKLNF DSNALYRQKDIMEYRDLDEEDPKEIEASKYDLSYISLDGNIGCMVNGAGLAMSTMDII KHYGGEPANFLDVGGGATAEKVTEAFKIILSDQNVKGIFVNIFGGIMKCDVIAEGVVE ATRQVGLTLPLVVRLEGTNVDLGKKILSESGLNITSAESMADGAQKIVSLV*" /label="sucC CDS" gene 1554252..1555409 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /label="sucC gene" promotor_no_box complement(1554324..1554424) /Source="Nicolas_upshift_promotors" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1554364) /Source="Nicolas_upshifts" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1555438..1556340 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9643546, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (alpha subunit)" /protein_id="NP_389492.1" /db_xref="EnsemblGenomes-Gn:BSU16100" /db_xref="EnsemblGenomes-Tr:CAB13483" /db_xref="GOA:P80865" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR005810" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017440" /db_xref="InterPro:IPR033847" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12681" /db_xref="UniProtKB/Swiss-Prot:P80865" /translation="MSVFINKDTRVIVQGITGSTALFHTKQMLEYGTNIVGGVTPGKG GTEAEGVPVFNTVAEAVQTTGANASVIYVPAPFAADAIMEAVDAELDLVICITEHIPV LDMVKVKRFMEGKKTRLIGPNCPGVITPEECKIGIMPGYIHKKGHVGVVSRSGTLTYE AVHQLSEAGVGQSTAVGIGGDPVNGTNFIDVLKAFNEDPDTHAVIMIGEIGGTAEEEA AEWVKANMTKPVVGFIGGKTAPPGKRMGHAGAIISGGKGTADEKIKTLNACGIEVAET PSVMGETLIKVLKEKNLFETCKTH*" /label="sucD CDS" gene 1555438..1556340 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /label="sucD gene" downshifts 1556330 /Source="Nicolas_upshifts" /id="D891" /incds=0 /nref=94 /ntot=208 /MaxReadThrough="5.40077" /MaxDrop="4.8878" /score="9.51199539" /energy="-15" /TU="U1317" /idTUdmin="U1315" /TUdmin=2130 /isTUend="FALSE" /label="downshifts" CDS 1556401..1557294 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA processing Smf single strand binding protein" /protein_id="NP_389493.1" /db_xref="EnsemblGenomes-Gn:BSU16110" /db_xref="EnsemblGenomes-Tr:CAB13484" /db_xref="GOA:P39813" /db_xref="InterPro:IPR003488" /db_xref="SubtiList:BG11006" /db_xref="UniProtKB/Swiss-Prot:P39813" /translation="MDQAAVCLTICRINQLLSPSLLLKWWKADPSMSLTSPVLQTVTR DQIKAAALKNEIEQFYPKLPRVLAAYREQGINTIPISSKQYPFWLKSIYDPPAVLFAK GDMTLLSKGRKIGIVGTRNPTAYGKQVVNHLTKEICRKGWVIVSGLASGIDGMSHAAS IKAKGRTIGVIAGGFQHIYPRENLQLADHMAKHHILLSEHPPETKPQKWHFPMRNRII SGLSEGVIVVQGKEKSGSLITAYQALEQGREVFAVPGSLFDPYAGGPIKLIQQGAKAI WSAEDIFEELPERNVQYTEPF*" /label="dprA CDS" gene 1556401..1557294 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /label="dprA gene" promotor_-35 1557300..1557307 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1557322..1557341 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1557329..1557481 /Source="Nicolas_S_feature" /locus_tag="new_1683508_1683660" /HighExp="dia15, H2O2, G/S, Paraq, Diami, S1, Oxctl, LBGexp, C30, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.111279" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigD, SigA, SigA" /TUlongPSig="1, 1, 1" /label="S583" upshifts 1557329 /Source="Nicolas_upshifts" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1557482..1559557 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /EC_number="5.99.1.2" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9580687, 12682299, 16585761, 23133654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9580687, 12682299, 16585761, 23133654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase I" /protein_id="NP_389494.1" /db_xref="EnsemblGenomes-Gn:BSU16120" /db_xref="EnsemblGenomes-Tr:CAB13485" /db_xref="GOA:P39814" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005733" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013498" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR028612" /db_xref="InterPro:IPR034149" /db_xref="SubtiList:BG11007" /db_xref="UniProtKB/Swiss-Prot:P39814" /translation="MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGV DIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDL NSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKK GLSAGRVQSVALRLIIDREKEINDFKPEEYWTIDGTFLKGQETFEASFFGKNGKKLPL NSEADVKEILSQLKGNQYTVEKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMM IAQQLYEGIDLGREGTVGLITYMRTDSTRISNTAVDEAAAFIDQTYGKEFLGGKRKPA KKNENAQDAHEAIRPTSVLRKPSELKAVLGRDQMRLYKLIWERFVASQMAPAVLDTMS VDLTNNGLTFRANGSKVKFSGFMKVYVEGKDDQMEEKDRMLPDLQEGDTVLSKDIEPE QHFTQPPPRYTEARLVKTLEERGIGRPSTYAPTLDTIQRRGYVALDNKRFVPTELGQI VLDLIMEFFPEIINVEFTAKMERDLDHVEEGNTEWVKIIDNFYTDFEKRVKKAESEMK EVEIEPEYAGEDCELCSSPMVYKMGRYGKFLACSNFPDCRNTKPIVKQIGVKCPSCGE GNIVERKSKKKRVFYGCDRYPDCEFVSWDKPIERKCPKCGKMLVEKKLKKGIQVQCVE CDYKEEPQK*" /label="topA CDS" gene 1557482..1559557 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /label="topA gene" downshifts 1559527 /Source="Nicolas_upshifts" /id="D892" /incds=0 /nref=48 /ntot=173 /MaxReadThrough="5.66787" /MaxDrop="4.5486" /score="0.939045188" /energy="-13.2" /TU="U1319" /idTUdmin="U1317" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 1559589..1559594 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1559601 /Source="Nicolas_upshifts" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1559610..1559628 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1559633..1560940 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /EC_number="2.1.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16027442, 21561081, 23095745, 23157377, 27825927, 28745052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16027442, 21561081, 23095745, 23157377, 27825927, 28745052; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA:m(5)U-54 methyltransferase" /protein_id="NP_389495.1" /db_xref="EnsemblGenomes-Gn:BSU16130" /db_xref="EnsemblGenomes-Tr:CAB13486" /db_xref="GOA:P39815" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004417" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11008" /db_xref="UniProtKB/Swiss-Prot:P39815" /translation="MNQQTVNVIGAGLAGSEAAWQLAKRGIQVKLYEMRPVKQTPAHH TDKFAELVCSNSLRSNTLANAVGVLKEEMRALDSAIIAAADECSVPAGGALAVDRHEF AASVTNRVKNHPNVTVINEEVTEIPEGPTIIATGPLTSESLSAQLKELTGEDYLYFYD AAAPIVEKDSLDMDKVYLKSRYDKGEAAYLNCPMTEEEFDRFHEALTSAETVPLKEFE KEIFFEGCMPIEVMAKRGKKTMLFGPMKPVGLEHPVTGKRPYAVVQLRQDDAAGTLYN IVGFQTHLKWGDQKEVLKLIPGLENVEIVRYGVMHRNTFINSPSLLKPTYQFKNRSDL FFAGQMTGVEGYVESAASGLVAGINAAKLVLGEELVIFPQETAIGSMAHYITTTNQKN FQPMNANFGLLKELPVKIKNKKERNEQYANRAIETIQTISKTI*" /label="trmFO CDS" gene 1559633..1560940 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /label="trmFO gene" promotor_-35 1560946..1560950 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1560967..1560986 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1560977 /Source="Nicolas_upshifts" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1561008..1561922 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /function="16.9: Replicate" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11208805, 16553881, 16597952, 21239579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11208805, 16553881, 16597952, 21239579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_389496.1" /db_xref="EnsemblGenomes-Gn:BSU16140" /db_xref="EnsemblGenomes-Tr:CAB13487" /db_xref="GOA:P39776" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011931" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG10965" /db_xref="UniProtKB/Swiss-Prot:P39776" /translation="MENVKNFVKLFVEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQG INGFEEAAYQDTRIFLTEAYEKGLSRRTISKKISALRSFYKFLMREKLIEENPFQLVH LPKQEKRIPKFLYQKELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITIND VDLFMDTVLVHGKGKKQRYIPFGSYAREALKVYMNSGRQCLLMKAKEPHDLLFVNQRG GPLTARGIRHILSGLVQKASSTLHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLS STQIYTHVSKEMLRNTYMSHHPRAFKKN*" /label="codV CDS" gene 1561008..1561922 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /label="codV gene" promotor_-35 1561047..1561051 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-35" upshifts 1561064 /Source="Nicolas_upshifts" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="upshifts" promotor_-10 1561067..1561086 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-10" CDS 1561935..1562480 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /EC_number="3.4.25.2" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (N-terminalserine protease)" /protein_id="NP_389497.1" /db_xref="EnsemblGenomes-Gn:BSU16150" /db_xref="EnsemblGenomes-Tr:CAB13488" /db_xref="GOA:P39070" /db_xref="InterPro:IPR001353" /db_xref="InterPro:IPR022281" /db_xref="InterPro:IPR023333" /db_xref="InterPro:IPR029055" /db_xref="PDB:1YYF" /db_xref="PDB:2Z3A" /db_xref="PDB:2Z3B" /db_xref="SubtiList:BG10966" /db_xref="UniProtKB/Swiss-Prot:P39070" /translation="MSSFHATTIFAVQHKGRSAMSGDGQVTFGQAVVMKHTARKVRKL FNGKVLAGFAGSVADAFTLFEKFEAKLEEYNGNLKRAAVELAKEWRSDKVLRKLEAML IVMNQDTLLLVSGTGEVIEPDDGILAIGSGGNYALAAGRALKKHAGESMSASEIARAA LETAGEICVYTNDQIILEELE*" /label="clpQ CDS" gene 1561935..1562480 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /label="clpQ gene" CDS 1562497..1563900 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (ATPase andchaperone)" /protein_id="NP_389498.1" /db_xref="EnsemblGenomes-Gn:BSU16160" /db_xref="EnsemblGenomes-Tr:CAB13489" /db_xref="GOA:P39778" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004491" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10967" /db_xref="UniProtKB/Swiss-Prot:P39778" /translation="MEKKPLTPRQIVDRLDQYIVGQQNAKKAVAVALRNRYRRSLLDE KLKDEVVPKNILMMGPTGVGKTEIARRIAKLSGAPFIKIEATKFTEVGYVGRDVESMV RDLVETSVRLIKEEKMNEVKEQAEENANKRIVRLLVPGKKKQSGVKNPFEMFFGGSQP NGEDEAESQEEANIEEKRKRMAHQLALGELEDYYVTVEVEEQQPSMFDMLQGSGMEQM GMNMQDALSGLMPKKKKRRKMTVREARKVLTNEEASKLIDMDEVGQEAVQRAEESGII FIDEIDKIAKNGGASSSADVSREGVQRDILPIVEGSTVVTKYGSVKTDHVLFIAAGAF HMAKPSDLIPELQGRFPIRVELNKLTVDDFVRILVEPDNALLKQYQALLQTEGISLEF SDEAIHKIAEVAYHVNQDTDNIGARRLHTILERLLEDLSFEAPDVTMEKITITPQYVE EKLGTIAKNKDLSQFIL*" /label="clpY CDS" gene 1562497..1563900 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /label="clpY gene" CDS 1563940..1564719 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, GTP and BCAA-dependent" /protein_id="NP_389499.1" /db_xref="EnsemblGenomes-Gn:BSU16170" /db_xref="EnsemblGenomes-Tr:CAB13490" /db_xref="GOA:P39779" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR013198" /db_xref="InterPro:IPR014154" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2B0L" /db_xref="PDB:2B18" /db_xref="PDB:2GX5" /db_xref="PDB:2HGV" /db_xref="PDB:5LNH" /db_xref="PDB:5LOE" /db_xref="PDB:5LOJ" /db_xref="PDB:5LOO" /db_xref="SubtiList:BG10968" /db_xref="UniProtKB/Swiss-Prot:P39779" /translation="MALLQKTRIINSMLQAAAGKPVNFKEMAETLRDVIDSNIFVVSR RGKLLGYSINQQIENDRMKKMLEDRQFPEEYTKNLFNVPETSSNLDINSEYTAFPVEN RDLFQAGLTTIVPIIGGGERLGTLILSRLQDQFNDDDLILAEYGATVVGMEILREKAE EIEEEARSKAVVQMAISSLSYSELEAIEHIFEELDGNEGLLVASKIADRVGITRSVIV NALRKLESAGVIESRSLGMKGTYIKVLNNKFLIELENLKSH*" /label="codY CDS" gene 1563940..1564719 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /label="codY gene" downshifts 1564694 /Source="Nicolas_upshifts" /id="D893" /incds=0 /nref=6 /ntot=130 /MaxReadThrough="5.35492" /MaxDrop="5.90286" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1564738 /Source="Nicolas_upshifts" /id="D894" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="4.95658" /MaxDrop="4.85551" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 1564839..1564846 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1564859..1564877 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1564870..1565023 /Source="Nicolas_S_feature" /locus_tag="new_1691049_1691202" /HighExp="C30, GM 90, GM 25, Cold, GM 15, GM 10, MG 150, GM-0.2, LBGstat, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 0.994, 0.998" /TUlongSig="SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.999, 1, 1, 1" /label="S584" upshifts 1564870 /Source="Nicolas_upshifts" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" promotor_-35 1564998..1565005 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1565020..1565039 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1565025 /Source="Nicolas_upshifts" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1565099..1565488 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996, 17850253, 25843804; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389500.1" /db_xref="EnsemblGenomes-Gn:BSU16180" /db_xref="EnsemblGenomes-Tr:CAB13491" /db_xref="GOA:P24500" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006300" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10237" /db_xref="UniProtKB/Swiss-Prot:P24500" /translation="MSLFSGTIQNLENALSRADIKQKVITNNIANIDTPNYKAKKVSF QNLLDQESSRLEAIKTDYRHVDFSDTDSNYSIVASGDTSYQQNGNNVDVDKEMTELAQ NQINYQALVERMNGKFNSLKTVLTGGK*" /label="flgB CDS" gene 1565099..1565488 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /label="flgB gene" CDS 1565488..1565940 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389501.1" /db_xref="EnsemblGenomes-Gn:BSU16190" /db_xref="EnsemblGenomes-Tr:CAB13492" /db_xref="GOA:P24501" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006299" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10238" /db_xref="UniProtKB/Swiss-Prot:P24501" /translation="MTAFHSLNVSASALTAQRVRMDVVSSNLANMDTTRAKQVNGEWV PYRRKMVSLQSKGESFSSILNSQMSGSGNAGNGVKVSKITEDDSDFNLVYDPTDPDAN AEGYVQKPNVDPLKEMVDLVSSTRSYEANVTAMNATKGMLMKALEIGK*" /label="flgC CDS" gene 1565488..1565940 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /label="flgC gene" CDS 1565951..1566271 /gene="fliE" /locus_tag="BSU_16200" /old_locus_tag="BSU16200" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133968, 1551848, 1905667, 2544561, 9161424, 11133968, 15136044; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal body protein" /protein_id="NP_389502.1" /db_xref="EnsemblGenomes-Gn:BSU16200" /db_xref="EnsemblGenomes-Tr:CAB13493" /db_xref="GOA:P24502" /db_xref="InterPro:IPR001624" /db_xref="SubtiList:BG10239" /db_xref="UniProtKB/Swiss-Prot:P24502" /translation="MINAISPFQVQNTQNTQNATNQVNNSQKTDSSNQTSFSELLKNS ISSLNESQVASDNMTNALAAGKDVNLDEVMIAAQKASISLTAATEFRNKAVEAYQEIM RMQM*" /label="fliE CDS" gene 1565951..1566271 /gene="fliE" /locus_tag="BSU_16200" /old_locus_tag="BSU16200" /label="fliE gene" downshifts complement(1566266) /Source="Nicolas_upshifts" /id="D895" /incds=0 /nref=1 /ntot=83 /MaxReadThrough="1.38909" /MaxDrop="2.66249" /score="0.0645368779" /energy="-7.4" /TU="NA" /idTUdmin="U1325" /TUdmin=2684 /isTUend="FALSE" /label="downshifts" CDS 1566317..1567927 /gene="fliF" /locus_tag="BSU_16210" /old_locus_tag="BSU16210" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1551848, 1905667, 2544561, 9161424, 11133968, 22670715, 24970213, 28089452; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal-body M-ring protein" /protein_id="NP_389503.1" /db_xref="EnsemblGenomes-Gn:BSU16210" /db_xref="EnsemblGenomes-Tr:CAB13494" /db_xref="GOA:P23447" /db_xref="InterPro:IPR000067" /db_xref="InterPro:IPR006182" /db_xref="InterPro:IPR013556" /db_xref="InterPro:IPR021157" /db_xref="SubtiList:BG10240" /db_xref="UniProtKB/Swiss-Prot:P23447" /translation="MNRTLMQMKNKTSEFWKNRSKLQKILMVSALAAIIIIGIIISVF ASNSKMAPLYKDLSAEEAGQIKEELDAKKVPNELSNGGTVISVPEDQVDSLKVQMAAE GLPKTGSIDYSFFGQNAGFGLTDNEFDMVKVKATQTELSNLINEMDGIKNSKVMINLP KDAVFVGEEQSAASASIVLQIQPGYTLDQSQINGLYHLVSKSVPNLKEDNIVIMDQNS TYYDKSDSDAGSYADSYSSQQGIKSQVEKDIQKHVQSLLGTMMGQDKVVVSVTADIDF TKENRTEDIVEPVDKENMEGIAVSAEKVSETYQGDGAANGGTAGTGEEDVTNYKADGE NTESGNYEKNSNKINYEVNRIHKEIAESPYKVRDLGIQVMVEPPDAKNTASLSTERQD DIQKILSTVVRTSLDKDETQNQNLSDADINNKIVVSVQPFDGKVNLDTNTEESSGIPL WAYIVGGVLIAAIIVLIIMLIRKKRAQEDEFEEYEYEVPQEPINLPDINEEENETAES VRRKQLEKMAKDKPEDFAKLLRSWLAED*" /label="fliF CDS" gene 1566317..1567927 /gene="fliF" /locus_tag="BSU_16210" /old_locus_tag="BSU16210" /label="fliF gene" CDS 1567940..1568956 /gene="fliG" /locus_tag="BSU_16220" /old_locus_tag="BSU16220" /function="16.5: Explore" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1551848, 1905667, 2544561, 9161424, 10440379, 11133968, 28089452; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing component" /protein_id="NP_389504.1" /db_xref="EnsemblGenomes-Gn:BSU16220" /db_xref="EnsemblGenomes-Tr:CAB13495" /db_xref="GOA:P23448" /db_xref="InterPro:IPR000090" /db_xref="InterPro:IPR011002" /db_xref="InterPro:IPR023087" /db_xref="InterPro:IPR028263" /db_xref="InterPro:IPR032779" /db_xref="SubtiList:BG10241" /db_xref="UniProtKB/Swiss-Prot:P23448" /translation="MARRDQDKLTGKQKAAILMISLGLDVSASVYKHLTDEEIERLTL EISGVRSVDHQKKDEIIEEFHNIAIAQDYISQGGLSYARQVLEKALGEDKAENILNRL TSSLQVKPFDFARKAEPEQILNFIQQEHPQTMALILSYLDPVQAGQILSELNPEVQAE VARRIAVMDRTSPEIINEVERILEQKLSSAFTQDYTQTGGIEAVVEVLNGVDRGTEKT ILDSLEIQDPDLAEEIKKRMFVFEDIVTLDNRAIQRVIRDVENDDLLLSLKVASEEVK EIVFNNMSQRMVETFKEEMEFMGPVRLKDVEEAQSRIVSIVRKLEEAGEIVIARGGGD DIIV*" /label="fliG CDS" gene 1567940..1568956 /gene="fliG" /locus_tag="BSU_16220" /old_locus_tag="BSU16220" /label="fliG gene" S_feature 1568957..1569074 /Source="Nicolas_S_feature" /locus_tag="new_1695136_1695253" /HighExp="Lbstat, C90, M0t90, M40t90, Lbtran, C30, LPhT, GM 90, M40t45, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigA" /TUshortPSig="0.998, 1, 0.998" /TUlongSig="SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.994, 1, 0.999, 1, 1, 1" /label="S585" promotor_no_box complement(1569020..1569120) /Source="Nicolas_upshift_promotors" /id="U1325" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.937062937062937" /psig="0.00999000999001" /xcortree=81 /SigmaFactorBS="ttgcctgctcagaaatccggtcagcttcctctttcactcggg ccataagcgcctccgggttctcttcagcctgcaaaaggtgagaatgatcaatacgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1569060) /Source="Nicolas_upshifts" /id="U1325" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.937062937062937" /psig="0.00999000999001" /xcortree=81 /SigmaFactorBS="ttgcctgctcagaaatccggtcagcttcctctttcactcggg ccataagcgcctccgggttctcttcagcctgcaaaaggtgagaatgatcaatacgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1569075..1569701 /gene="fliH" /locus_tag="BSU_16230" /old_locus_tag="BSU16230" /function="16.6: Maintain" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1828465, 12217691, 16522800, 17002279, 26916245; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar export apparatus subunit of cytoplasmic ATPase" /protein_id="NP_389505.2" /db_xref="EnsemblGenomes-Gn:BSU16230" /db_xref="EnsemblGenomes-Tr:CAB13496" /db_xref="GOA:P23449" /db_xref="InterPro:IPR018035" /db_xref="InterPro:IPR022524" /db_xref="SubtiList:BG10242" /db_xref="UniProtKB/Swiss-Prot:P23449" /translation="MARVKEEADRISEQANSHIENIRRQIEQEKNDWAAEKQKLIEEA KAEGFEQGVALGKAEAMKQYAELIGQANSITEMSRKAVEDKLEDANEEIVELAVALAK KVWQQKSDDKEAFLLLVQQVINEVKEYDDISIYVDPYYYETIFQQKDEIQQLLYKECR LGIYADEKAQKGTCYIETPFGRVDASVDTQLMQLKDKLLTALEAGAAE*" /label="fliH CDS" gene 1569075..1569701 /gene="fliH" /locus_tag="BSU_16230" /old_locus_tag="BSU16230" /label="fliH gene" CDS 1569698..1571014 /gene="fliI" /locus_tag="BSU_16240" /old_locus_tag="BSU16240" /EC_number="3.6.3.14" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12787361, 16113269, 16780875, 17002279, 26916245; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="flagellar-specific ATPase subunit of export apparatus" /protein_id="NP_389506.2" /db_xref="EnsemblGenomes-Gn:BSU16240" /db_xref="EnsemblGenomes-Tr:CAB13497" /db_xref="GOA:P23445" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000225" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005714" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR022425" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032463" /db_xref="SubtiList:BG10243" /db_xref="UniProtKB/Swiss-Prot:P23445" /translation="MKTQSLIDCIEMTDSYKRYGKVKRVIGLMIESKGPASSIGDLCL IYAKGQSGKVIKAEVVGFQEENILLMPYLEAASIAPGSIVEATGESLRVKVGTGLIGQ VIDAFGEPLDGKLLPKGLSPVSTEQSPPNPMKRPPIREKMGVGVRSIDSLLTVGKGQR IGIFAGSGVGKSTLMGMIAKQTEADLNVIALVGERGREVREFIEKDLGKEGLKRSIVV VATSDQPALMRLKAAYTATAIAEYFRDKGQNVMFMMDSVTRVAMAQREIGLAAGEPPT TKGYTPSVFAILPRLLERTGANEHGTITAFYTVLVDGDDMNEPIADTVRGILDGHIVL DRALANKGQFPAVNVLKSISRVMSNISTKQHLDAANKFRELLSTYQNSEDLINIGAYK RGSSREIDEAIQFYPQLIQFLKQGTDEPALLEESIAALTSLTGNEE*" /label="fliI CDS" gene 1569698..1571014 /gene="fliI" /locus_tag="BSU_16240" /old_locus_tag="BSU16240" /label="fliI gene" CDS 1571017..1571460 /gene="fliJ" /locus_tag="BSU_16250" /old_locus_tag="BSU16250" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17088562, 26916245, 26984495, 27647891; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar synthesis rod subunit of export ATPase" /protein_id="NP_389507.1" /db_xref="EnsemblGenomes-Gn:BSU16250" /db_xref="EnsemblGenomes-Tr:CAB13498" /db_xref="GOA:P20487" /db_xref="InterPro:IPR012823" /db_xref="SubtiList:BG10245" /db_xref="UniProtKB/Swiss-Prot:P20487" /translation="MAYQFRFQKLLELKENEKDQSLSEYQQSVSEFENVAEKLYENMS KKELLEQNKEKKLKSGMSVQEMRHYQQFVSNLDNTIYHYQKLVIMKRNQMNQKQEILT EKNIEVKKFEKMREKQFKMFALEDKAAEMKEMDDISIKQFMIQGH*" /label="fliJ CDS" gene 1571017..1571460 /gene="fliJ" /locus_tag="BSU_16250" /old_locus_tag="BSU16250" /label="fliJ gene" CDS 1571472..1572086 /gene="ylxF" /locus_tag="BSU_16260" /old_locus_tag="BSU16260" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17586671, 22307758; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative kinesin-like protein" /protein_id="NP_389508.2" /db_xref="EnsemblGenomes-Gn:BSU16260" /db_xref="EnsemblGenomes-Tr:CAB13499" /db_xref="GOA:P23454" /db_xref="InterPro:IPR006668" /db_xref="InterPro:IPR011002" /db_xref="SubtiList:BG10246" /db_xref="UniProtKB/Swiss-Prot:P23454" /translation="MSGKKKESGKFRSVLLIIILPLMFLLIAGGIVLWAAGINVLKPI QDAAAKTPVLKELVPETENKKGAASSKDSSNTAALEKTIKDQKSEISILNKDLETSKS EIDRLNQKIRSLEKTAEDQKKSSEDHTEGSADSKASSENDKVISVYKSMDSGKAAKII AQLKEQEALKILNGLSKKQLADILAKMTPEQAATYTEKIAASQE*" /label="ylxF CDS" gene 1571472..1572086 /gene="ylxF" /locus_tag="BSU_16260" /old_locus_tag="BSU16260" /label="ylxF gene" CDS 1572099..1573562 /gene="fliK" /locus_tag="BSU_16270" /old_locus_tag="BSU16270" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16630628, 16949608, 28557186; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook-length control protein (ruler)" /protein_id="NP_389509.2" /db_xref="EnsemblGenomes-Gn:BSU16270" /db_xref="EnsemblGenomes-Tr:CAB13500" /db_xref="GOA:P23451" /db_xref="InterPro:IPR001635" /db_xref="InterPro:IPR021136" /db_xref="SubtiList:BG10247" /db_xref="UniProtKB/Swiss-Prot:P23451" /translation="MKLLELAGPLLQTTTGSAAKNMKSSQGVFQNWLMSEAGLKELSE QGKGTPNSEDQLLADALKKIGEWLNASPEDQDKQNADLLQTLSKLTGKQLDANALQML QNLLQAVESKMSGGTDQLLTETEKIFSEAKTALSANDSASDINGALKSDKEQSNQENE VSEPAKELIYIQMFISQLVEGNKLTDLGNGNEAHAIYQNGDQFLSALEKKGVSQQLIQ DLKQQIFTKAESSSKLYSMTASELKSFQSLMDQMSMLPQKGTKEWSLAESQLKAFLLS KSSESSQDFGKSVLTPLSQSSSSKNASDVSGSIQPVDSKSGLQMLFSGYRGIGGVQTL DLQQMSSDIPNAETKTVADQVINAWKQMKYTPFGRSTGSFTIRLNPEHLGFVTIKLTN ENGMFQSKIIASSQSAKELLEQHLPQLKQSLPNMAVQIDRFTLPVQSGDQPIYGQLAD EQKQQQEGQRQQRQKKQSNDFGDLLDEVSMVEMEEEE*" /label="fliK CDS" gene 1572099..1573562 /gene="fliK" /locus_tag="BSU_16270" /old_locus_tag="BSU16270" /label="fliK gene" CDS 1573559..1573981 /gene="flgD" /locus_tag="BSU_16280" /old_locus_tag="BSU16280" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8157595, 14563871, 24748615; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook capping protein" /protein_id="NP_389510.1" /db_xref="EnsemblGenomes-Gn:BSU16280" /db_xref="EnsemblGenomes-Tr:CAB13501" /db_xref="GOA:P23455" /db_xref="InterPro:IPR005648" /db_xref="SubtiList:BG10248" /db_xref="UniProtKB/Swiss-Prot:P23455" /translation="MTSISSEYKLPEKTNTVSTNNSSLGKDEFLKILMTQVQNQDPLN PIDDKEFISQMATFSSLEQMMNLNTTMTQFVENQDPFTTYVDWMGKEVSWTDGKSATD KTGTVSSVKHFKGNYYLVLDDGTEISPANVMSVGQSSK*" /label="flgD CDS" gene 1573559..1573981 /gene="flgD" /locus_tag="BSU_16280" /old_locus_tag="BSU16280" /label="flgD gene" CDS 1574003..1574797 /gene="flgE" /locus_tag="BSU_16290" /old_locus_tag="BSU16290" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15502333, 15510139, 27759043, 28120828, 28429800; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook protein" /protein_id="NP_389511.2" /db_xref="EnsemblGenomes-Gn:BSU16290" /db_xref="EnsemblGenomes-Tr:CAB13502" /db_xref="GOA:P23446" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR012836" /db_xref="InterPro:IPR019776" /db_xref="InterPro:IPR020013" /db_xref="SubtiList:BG10249" /db_xref="UniProtKB/Swiss-Prot:P23446" /translation="MLRSLYSGISGMKNFQTKLDVIGNNIANVNTVGFKKSRVTFKDM VSQTIAGGSAAGATIGGTNSKQIGLGSSSGTIDTIHSTSATQSTGRTLDLAIDGDGYF RIDTGDGTAYTRAGNFYLDNTGTLVTGDGYHVLNMNGGTIKIPTDAQSFSIGSDGKVS IVDAEGKTQDGGQIGIVTFANSDGLDKIGSNLYRESLNSGTASAANQPGDGGTGALKS GFLEMSNVDLTDEFTEMIVAQRGFQSNSKIITTSDEILQELVNLKR*" /label="flgE CDS" gene 1574003..1574797 /gene="flgE" /locus_tag="BSU_16290" /old_locus_tag="BSU16290" /label="flgE gene" CDS 1574837..1575052 /gene="swrD" /locus_tag="BSU_16299" /old_locus_tag="BSU16299" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9168127, 29061663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9168127, 29061663; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar power transducer required for swarming" /protein_id="YP_003097728.1" /db_xref="EnsemblGenomes-Gn:BSU16299" /db_xref="EnsemblGenomes-Tr:CAX52619" /db_xref="InterPro:IPR009384" /db_xref="UniProtKB/Swiss-Prot:C0H412" /translation="MIKVTRLNGQPFTLNALFIEQIECFPDTTITLSNGKKFVVKEDE EAVLEKIAAFYRKIQIFAMDQGIEEPE*" /label="swrD CDS" gene 1574837..1575052 /gene="swrD" /locus_tag="BSU_16299" /old_locus_tag="BSU16299" /label="swrD gene" CDS 1575049..1575471 /gene="fliL" /locus_tag="BSU_16300" /old_locus_tag="BSU16300" /function="16.5: Explore" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10439416, 12787361, 16166542, 23264580, 25714720, 28717192; Product type f : factor" /codon_start=1 /transl_table=11 /product="flagellar basal-body (stator) associated protein" /protein_id="NP_389512.1" /db_xref="EnsemblGenomes-Gn:BSU16300" /db_xref="EnsemblGenomes-Tr:CAB13503" /db_xref="GOA:P23452" /db_xref="InterPro:IPR005503" /db_xref="SubtiList:BG10250" /db_xref="UniProtKB/Swiss-Prot:P23452" /translation="MKKKLMIILLIILIVIGALGAAAYFVLGGKSEKSEAKKSIDEIV ASSVDVEEITTNLKSDNIIRLAIKLETDSDKSKEELEKRDFQVKDAVISLLADTNADQ IEGDKGKETFKKELKDKINSYLQEGKVEKVYITSFNLQ*" /label="fliL CDS" gene 1575049..1575471 /gene="fliL" /locus_tag="BSU_16300" /old_locus_tag="BSU16300" /label="fliL gene" CDS 1575505..1576503 /gene="fliM" /locus_tag="BSU_16310" /old_locus_tag="BSU16310" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7787061, 16547037, 16796690, 16882724, 17015643, 17050923, 22720735, 28625846; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing component" /protein_id="NP_389513.1" /db_xref="EnsemblGenomes-Gn:BSU16310" /db_xref="EnsemblGenomes-Tr:CAB13504" /db_xref="GOA:P23453" /db_xref="InterPro:IPR001543" /db_xref="InterPro:IPR001689" /db_xref="InterPro:IPR028976" /db_xref="InterPro:IPR036429" /db_xref="SubtiList:BG10251" /db_xref="UniProtKB/Swiss-Prot:P23453" /translation="MSGEVLSQNEIDALLSAISTGEMDAEELKKEEKEKKVKVYDFKR ALRFSKDQIRSLTRIHDNFARLLTTHFSAQLRTYIHISVSSVDQVPYEEFIRSIPNMT ILNLFDVHPMEGRIMMEVNPTIAYTMMDRVMGGIGISHNKVDSLTEIETKIISNLFEN ALGNYKEAWQSIADIEPEMTEFEVNPQFVQMVSPNETVVVISLNTQIGEISGVINLCI PHIVLEPLIPKLSVHYWMQSDRNEPKPEETKSLEKRIMTAQIPVVAELGTSELTIEEF LSLEVGDCITLDKSVTDPLTVLVGDKPKFLGQAGRVNRKQAVQILDHDIRGEQDGE*" /label="fliM CDS" gene 1575505..1576503 /gene="fliM" /locus_tag="BSU_16310" /old_locus_tag="BSU16310" /label="fliM gene" CDS 1576493..1577629 /gene="fliY" /locus_tag="BSU_16320" /old_locus_tag="BSU16320" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12920116, 16547037, 16796690, 16882724, 17015643, 17050923, 23226535, 23532838, 26195616" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12920116, 16547037, 16796690, 16882724, 17015643, 17050923, 23226535, 23532838, 26195616; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing phosphatase" /protein_id="NP_389514.1" /db_xref="EnsemblGenomes-Gn:BSU16320" /db_xref="EnsemblGenomes-Tr:CAB13505" /db_xref="GOA:P24073" /db_xref="InterPro:IPR001172" /db_xref="InterPro:IPR001543" /db_xref="InterPro:IPR007597" /db_xref="InterPro:IPR012826" /db_xref="InterPro:IPR028976" /db_xref="InterPro:IPR036429" /db_xref="SubtiList:BG10252" /db_xref="UniProtKB/Swiss-Prot:P24073" /translation="MENNRLSQDEIDALLNGTGSTLDEPEIPEVDDLSEMERDAIGEI GNISFGSSATALSTLLNQKVDITTPSVTVIPRSKISDAFPEPYVAIEVNYTEGFSGSN LLVVEQSDAAIIADLMIGGDGKGADPSLGEIHLSAVQEAMNQMMGSAATSMSTVFSKK IDISPPRVELLDVTEEKGTDRIPDDEMLVKVSFNLKVGELIDSSIMQLYPLTFAKDLI SSLMNSESAEEEETVQPEVTYEQPKEPVTPEPRIEPKQQQQPPKRQGTAKKAAPVQVS PVEFSAFDPNEAVQAPIHNLDMLLDIPLSITVELGRTKRSVKEILELSAGSIIELDKL AGEPVDILVNQRIVAKGEVVVIEENFGVRVTDILSQAERINNLK*" /label="fliY CDS" gene 1576493..1577629 /gene="fliY" /locus_tag="BSU_16320" /old_locus_tag="BSU16320" /label="fliY gene" CDS 1577655..1578017 /gene="cheY" /locus_tag="BSU_16330" /old_locus_tag="BSU16330" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10196193, 12864845, 12920116, 14749334, 23226535, 28542702" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10196193, 12864845, 12920116, 14749334, 23226535, 28542702; Product type r : regulator" /codon_start=1 /transl_table=11 /product="regulator of chemotaxis and motility" /protein_id="NP_389515.1" /db_xref="EnsemblGenomes-Gn:BSU16330" /db_xref="EnsemblGenomes-Tr:CAB13506" /db_xref="GOA:P24072" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG10258" /db_xref="UniProtKB/Swiss-Prot:P24072" /translation="MAHRILIVDDAAFMRMMIKDILVKNGFEVVAEAENGAQAVEKYK EHSPDLVTMDITMPEMDGITALKEIKQIDAQARIIMCSAMGQQSMVIDAIQAGAKDFI VKPFQADRVLEAINKTLN*" /label="cheY CDS" gene 1577655..1578017 /gene="cheY" /locus_tag="BSU_16330" /old_locus_tag="BSU16330" /label="cheY gene" CDS 1578032..1578691 /gene="fliZ" /locus_tag="BSU_16340" /old_locus_tag="BSU16340" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10791024, 1597417, 16513753, 24204316; Product type r: regulator" /codon_start=1 /transl_table=11 /product="flagellar regulatory protein" /protein_id="NP_389516.1" /db_xref="EnsemblGenomes-Gn:BSU16340" /db_xref="EnsemblGenomes-Tr:CAB13507" /db_xref="GOA:P35536" /db_xref="InterPro:IPR022781" /db_xref="SubtiList:BG10259" /db_xref="UniProtKB/Swiss-Prot:P35536" /translation="MKKSQYFIVFICFFVLFSVHPIAAAAADSDNSTVNEWFQKKDEK TADQSEQKKEKTTKTADETEGAAAPSVSAFDFVKMIFALLFVIVLIYGLVKLMNKRNR LLKPFQYVENIGGTSVGQNRSIQLIKVGKSVLVVGVGETIQLLKEIEDEKEIEVILSQ HEEAMSSKIEWQKFVKPLKSSEHQPQQKLPSFSKALKEQLEELKQNRSEGKKKGPRHH E*" /label="fliZ CDS" gene 1578032..1578691 /gene="fliZ" /locus_tag="BSU_16340" /old_locus_tag="BSU16340" /label="fliZ gene" CDS 1578684..1579349 /gene="fliP" /locus_tag="BSU_16350" /old_locus_tag="BSU16350" /function="16.3: Control" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15516571, 15849754, 16850406, 22720735, 26244495, 27855178, 28559296; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389517.1" /db_xref="EnsemblGenomes-Gn:BSU16350" /db_xref="EnsemblGenomes-Tr:CAB13508" /db_xref="GOA:P35528" /db_xref="InterPro:IPR005837" /db_xref="InterPro:IPR005838" /db_xref="SubtiList:BG10260" /db_xref="UniProtKB/Swiss-Prot:P35528" /translation="MNEFINIFSSSDPENVSSTVKLLLLLTVFSVAPGILILMTCFTR IVIVLSFVRTSLATQSMPPNQVLIGLALFLTFFIMAPTFSEINKEALTPLMDNKISLD EAYTKAEEPIKEFMSKHTRQKDLALFMNYAKMDKPESLKDIPLTTMVPAFAISELKTA FQIGFMIFIPFLIIDMVVASVLMSMGMMMLPPVMISLPFKILLFVLVDGWYLIVKSLL QSF*" /label="fliP CDS" gene 1578684..1579349 /gene="fliP" /locus_tag="BSU_16350" /old_locus_tag="BSU16350" /label="fliP gene" CDS 1579364..1579633 /gene="fliQ" /locus_tag="BSU_16360" /old_locus_tag="BSU16360" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10234819, 15516571, 27855178; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389518.1" /db_xref="EnsemblGenomes-Gn:BSU16360" /db_xref="EnsemblGenomes-Tr:CAB13509" /db_xref="GOA:P35535" /db_xref="InterPro:IPR002191" /db_xref="InterPro:IPR006305" /db_xref="SubtiList:BG10261" /db_xref="UniProtKB/Swiss-Prot:P35535" /translation="MSSEFVISMAEKAVYVTLMISGPLLAIALLVGLIVSIFQATTQI QEQTLAFIPKIVAVLLALIFFGPWMLSTILSFTTELFSNLNRFAG*" /label="fliQ CDS" gene 1579364..1579633 /gene="fliQ" /locus_tag="BSU_16360" /old_locus_tag="BSU16360" /label="fliQ gene" CDS 1579641..1580420 /gene="fliR" /locus_tag="BSU_16370" /old_locus_tag="BSU16370" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15060055, 15516571, 15849754, 16850406, 28771474; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389519.2" /db_xref="EnsemblGenomes-Gn:BSU16370" /db_xref="EnsemblGenomes-Tr:CAB13510" /db_xref="GOA:P35537" /db_xref="InterPro:IPR002010" /db_xref="InterPro:IPR006303" /db_xref="SubtiList:BG10262" /db_xref="UniProtKB/Swiss-Prot:P35537" /translation="MNSIIDLFPAFLLVFIRISAFFVTIPLFGHRNVPAVHRIGFAFF LAVICFSTIDKPPSLEIDEHYMLLAFKEALVGLCLGLIAYMMIAAVQIAGSFIDFQMG FSIANVIDPQTGAQSPLIGQFIYTMALLFMLSVNAHHLLLDGIYYSFQYISVDQAFPN FGDEKFAYFIAKSFNAMFIIAFQMSAPVVASLFLVDLALGIVARTVPQLNVFVVGLPL KIAVSFIMLIVCMSVIFVVVRNVFSLTIETMRNLLALVGVS*" /label="fliR CDS" gene 1579641..1580420 /gene="fliR" /locus_tag="BSU_16370" /old_locus_tag="BSU16370" /label="fliR gene" CDS 1580420..1581502 /gene="flhB" /locus_tag="BSU_16380" /old_locus_tag="BSU16380" /function="16.1: Circulate" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10234819, 16949608, 17050924, 17067800, 28557186, 28771466; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389520.1" /db_xref="EnsemblGenomes-Gn:BSU16380" /db_xref="EnsemblGenomes-Tr:CAB13511" /db_xref="GOA:P35538" /db_xref="InterPro:IPR006135" /db_xref="InterPro:IPR006136" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG10543" /db_xref="UniProtKB/Swiss-Prot:P35538" /translation="MKLRVDLQFFAGEKTEKATPKKRKDTRKKGQVAKSSDVNTAVSL LVIFLSLIAIGPYMRDRLLSFIETFYTESLTMKLSESNVHTLFVSLLKDMGMILAPIL LVALVAGVVSNYMQVGFLFSAEVIQPKLEKLDPIKGFKRIYSMRAIVELIKSILKIVV VGFAAFAVLWLHYGEILRLPLLTPEEALSFVSKLTLWMGLSGAGALLILAGLDYLYQR FDYEKNIKMSKQDIKDEYKKSEGDPIIKSKIKQRQREMAMRRMMQEVPKADVIITNPT HYAIALKYDEEKMDAPYIVAKGVDHLALKIRKIAKEHDVMMVENRPLARALYDQVEID QAVPEEFFKVLAEILAYVYKTKQKVY*" /label="flhB CDS" gene 1580420..1581502 /gene="flhB" /locus_tag="BSU_16380" /old_locus_tag="BSU16380" /label="flhB gene" CDS 1581535..1583568 /gene="flhA" /locus_tag="BSU_16390" /old_locus_tag="BSU16390" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10234819, 15516571, 20534509, 28771466" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10234819, 15516571, 20534509, 28771466; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389521.2" /db_xref="EnsemblGenomes-Gn:BSU16390" /db_xref="EnsemblGenomes-Tr:CAB13512" /db_xref="GOA:P35620" /db_xref="InterPro:IPR001712" /db_xref="InterPro:IPR006301" /db_xref="InterPro:IPR025505" /db_xref="PDB:3MIX" /db_xref="SubtiList:BG10542" /db_xref="UniProtKB/Swiss-Prot:P35620" /translation="MSTRDLSVLISVVLIVAMLVIPFPPWLLSILIIINISLALIVLL TTMNMQEALQFSIFPSLLLLLTLFRLGLNVSTTRSILSHGEGGKVVETFGNFVVGGNV LVGLVVFIILIIIQFIVITKGAERVSEVAARFTLDAMPGKQMSIDADLNAGMITEQEA KHRREKVAREADFYGAMDGASKFVKGDAIAGIIIVMINIIFGIVIGMLQQGMSIQEAA SHFTMLTVGDGIVSQIPALLISTATGIVVTRAASEGNLGHDITGQLFAYPKLLYVAAA TIMLLGIFTPIGILLTGPLAGLLAFGAYTLSKSGKEKEEVDEILEEEAEVDELKSPES VVQLLHIDPIEFEFGYGLIPLADANQGGDLLDRIVMIRRQLALELGLVIPVVRIRDNI ALQPNEYRLKIKGNEVAKGELLLDHYLAMSPTPEDDLIEGIETVEPSFGLPAKWISEA VKDEADMLGYTVVDPASVVSTHITEKIKQHAHELIGRQETKQLIDHLKESYPVLVEEV TPNPLSVGDIQKVLAKLLKEKVSIRNLVTIFETLADYGKLTTDSDLLTEYTRQALAKQ ITAQFAKENEVLKVVTCSGRVEKAIADGVQQTEHGNYLSLEPDISESIVRSVAKEAEQ LSLRQETAILLCSPPVRMYVKQLLERYFPDLPVLSYNELEANVEVQSIGVVDI*" /label="flhA CDS" gene 1581535..1583568 /gene="flhA" /locus_tag="BSU_16390" /old_locus_tag="BSU16390" /label="flhA gene" CDS 1583568..1584668 /gene="flhF" /locus_tag="BSU_16400" /old_locus_tag="BSU16400" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1447978, 15317803, 16980502, 17565194, 17699634, 26195616, 27807433; Product type t: transporter" /codon_start=1 /transl_table=11 /product="GTPase involved in the export of flagella and number regulation" /protein_id="NP_389522.1" /db_xref="EnsemblGenomes-Gn:BSU16400" /db_xref="EnsemblGenomes-Tr:CAB13513" /db_xref="GOA:Q01960" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR020006" /db_xref="InterPro:IPR027417" /db_xref="PDB:2PX0" /db_xref="PDB:2PX3" /db_xref="PDB:3SYN" /db_xref="SubtiList:BG10544" /db_xref="UniProtKB/Swiss-Prot:Q01960" /translation="MKIKKFTAASMQEAALLIRKELGNEAVILNSKKIKKRKWFGLVN KPAVEVIAVLDQDFLEKKTPQKAAEPKQTLKTPVSSPKIEERTYPPQIPAQQELGDFS AYQSVLPEPLRKAEKLLQETGIKESTKTNTLKKLLRFSVEAGGLTEENVVGKLQEILC DMLPSADKWQEPIHSKYIVLFGSTGAGKTTTLAKLAAISMLEKHKKIAFITTDTYRIA AVEQLKTYAELLQAPLEVCYTKEEFQQAKELFSEYDHVFVDTAGRNFKDPQYIDELKE TIPFESSIQSFLVLSATAKYEDMKHIVKRFSSVPVNQYIFTKIDETTSLGSVFNILAE SKIGVGFMTNGQNVPEDIQTVSPLGFVRMLCR*" /label="flhF CDS" gene 1583568..1584668 /gene="flhF" /locus_tag="BSU_16400" /old_locus_tag="BSU16400" /label="flhF gene" promotor_-10 complement(1584545..1584564) /Source="Nicolas_upshift_promotors" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1584552) /Source="Nicolas_upshifts" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1584578..1584587) /Source="Nicolas_upshift_promotors" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1584659..1585555 /gene="flhG" /locus_tag="BSU_16410" /old_locus_tag="BSU16410" /function="16.5: Explore" /function="16.6: Maintain" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15361076, 25733861, 26411371" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15361076, 25733861, 26411371; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATPase affecting flagellar basal body localisation and number" /protein_id="NP_389523.1" /db_xref="EnsemblGenomes-Gn:BSU16410" /db_xref="EnsemblGenomes-Tr:CAB13514" /db_xref="GOA:P40742" /db_xref="InterPro:IPR025501" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033756" /db_xref="InterPro:IPR033875" /db_xref="PDB:3SYN" /db_xref="SubtiList:BG10254" /db_xref="UniProtKB/Swiss-Prot:P40742" /translation="MQMNRYDQAATLRAKMEKRERVLPMVYSQKAKTLAVISGKGGVG KSNITLNMALALQDKGKKVLLIDLDIGMGNIDILIGNSSSATIIDVLTDRKPLLQSLS VGPKGLRYISGGTGLDVMFQLDQRKWTFFANELSHALSQFDYVLFDMGAGLSKDQLPF ILSAEDILIITTPEPTAIMDAYSAVKHLVLTENKLSMKVAVNRCRDQKEGLDAFARLS RTIHMFLDVQVQFAGSVSDDVIVSKAVVEQVPFFIKSPQAKASRSVRILADALFEREE TRHKEDKQTFIEKLSSFLMRRA*" /label="flhG CDS" gene 1584659..1585555 /gene="flhG" /locus_tag="BSU_16410" /old_locus_tag="BSU16410" /label="flhG gene" CDS 1585557..1586630 /gene="cheB" /locus_tag="BSU_16420" /old_locus_tag="BSU16420" /EC_number="3.1.1.61" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1738311, 10632876, 12123464, 21515776" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1738311, 10632876, 12123464, 21515776; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis proteins (MCP)-glutamate methylesterase" /protein_id="NP_389524.2" /db_xref="EnsemblGenomes-Gn:BSU16420" /db_xref="EnsemblGenomes-Tr:CAB13515" /db_xref="GOA:Q05522" /db_xref="InterPro:IPR000673" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR008248" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR035909" /db_xref="SubtiList:BG10255" /db_xref="UniProtKB/Swiss-Prot:Q05522" /translation="MIRVLVVDDSAFMRKMISDFLTEEKQIEVIGTARNGEEALKKIE LLKPDVITLDVEMPVMNGTDTLRKIIEIYNLPVIMVSSQTEKGKECTINCLEIGAFDF ITKPSGSISLDLYKIKEQLVERVVAAGLSGKRKRPVSQTVRPEPIVRAVVKPELSKPK PGTGRQIVCIGTSTGGPRALQKVIPKLPKDLNAPVVVVQHMPEGFTASLADRLNHLSD IQVKEAKDGEAALNGCVYIAPGGKNISVIKNSEGLQVVLDNHDTPSRHKPSADYLFRS VGKLTDYEKVAVIMTGMGSDGTAGLKDMLTAGNVKAIAESEESCVVYGMPKAAVKAGL IHEIKHVEDIAASITSCVKKERV*" /label="cheB CDS" gene 1585557..1586630 /gene="cheB" /locus_tag="BSU_16420" /old_locus_tag="BSU16420" /label="cheB gene" CDS 1586636..1588654 /gene="cheA" /locus_tag="BSU_16430" /old_locus_tag="BSU16430" /EC_number="2.7.3.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:12094812, 12864845, 12920116, 15451661, 16045621, 21515776, 22355139" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12094812, 12864845, 12920116, 15451661, 16045621, 21515776, 22355139; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="chemotactic two-component sensor histidine kinase" /protein_id="NP_389525.2" /db_xref="EnsemblGenomes-Gn:BSU16430" /db_xref="EnsemblGenomes-Tr:CAB13516" /db_xref="GOA:P29072" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004105" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR008207" /db_xref="InterPro:IPR010808" /db_xref="InterPro:IPR035891" /db_xref="InterPro:IPR036061" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036641" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037006" /db_xref="InterPro:IPR037052" /db_xref="SubtiList:BG10256" /db_xref="UniProtKB/Swiss-Prot:P29072" /translation="MDMNQYLDVFIDESKEHLQTCNEKLLLLEKDPTDLQLVHDIFRA AHTLKGMSATMGYTDLAHLTHLLENVLDAIRNGDMEVTSDWLDILFEALDHLETMVQS IIDGGDGKRDISEVSAKLDVNGAHAESAASAEPAEAQSSASDWEYDEFERTVIQEAEE QGFKRYEIKISLNENCMLKAVRVYMVFEKLNEVGEVAKTIPSAEVLETEDFGTDFQVC FLTHQSAEDIEQLINGVSEIEHVEVIQGAPLTSAEKPEESKQEDSPAAAVPAKQEKQK QPAKNDEQAKHSAGGSKTIRVNIDRLDSLMNLFEELVIDRGRLEQIAKELEHNELTET VERMTRISGDLQSIILNMRMVPVETVFNRFPRMIRQLQKELNKKIELSIIGAETELDR TVIDEIGDPLVHLIRNSIDHGIEAPETRLQKGKPESGKVVLKAYHSGNHVFIEVEDDG AGLNRKKILEKALERGVITEKEAETLEDNQIYELIFAPGFSTADQISDISGRGVGLDV VKNKLESLGGSVSVKSAEGQGSLFSIQLPLTLSIISVLLIKLEEETFAIPISSIIETA VIDRKDILQTHDREVIDFRGHIVPVVYLKEEFKIEDTRKDAEQLHIIVVKKGDKPTAF VVDSFIGQQEVVLKSLGDYLTNVFAISGATILGDGEVALIIDCNALII*" /label="cheA CDS" gene 1586636..1588654 /gene="cheA" /locus_tag="BSU_16430" /old_locus_tag="BSU16430" /label="cheA gene" CDS 1588676..1589146 /gene="cheW" /locus_tag="BSU_16440" /old_locus_tag="BSU16440" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12864845, 15451661, 1624415, 8169223, 8169224" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12864845, 15451661, 1624415, 8169223, 8169224; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulation of CheA activity in response to attractants (chemotaxis)" /protein_id="NP_389526.1" /db_xref="EnsemblGenomes-Gn:BSU16440" /db_xref="EnsemblGenomes-Tr:CAB13517" /db_xref="GOA:P39802" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR036061" /db_xref="SubtiList:BG10692" /db_xref="UniProtKB/Swiss-Prot:P39802" /translation="MTAEIKTGEKMIVFMVNGKEYAISVTQVKSIEKWQKPTRVPGVE PYICGVINLRGVVTPVIDLRKRLNLPEYEITDETRIIIIAYRDIEVGWIVDEANDVIT VHESEIESAPEGVQKDTDVSIEQIVKQENRLLNIIDANAVLDKESSQSAVPDQA*" /label="cheW CDS" gene 1588676..1589146 /gene="cheW" /locus_tag="BSU_16440" /old_locus_tag="BSU16440" /label="cheW gene" CDS 1589165..1589794 /gene="cheC" /locus_tag="BSU_16450" /old_locus_tag="BSU16450" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12920116, 14749334, 14993307, 15546616, 16469702, 18990184, 22720735, 23226535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12920116, 14749334, 14993307, 15546616, 16469702, 18990184, 22720735, 23226535; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="signal terminating phosphatase of CheR-mediated methylation of methyl-accepting chemotaxis proteins (MCPs)" /protein_id="NP_389527.1" /db_xref="EnsemblGenomes-Gn:BSU16450" /db_xref="EnsemblGenomes-Tr:CAB13518" /db_xref="GOA:P40403" /db_xref="InterPro:IPR007597" /db_xref="InterPro:IPR028976" /db_xref="SubtiList:BG10749" /db_xref="UniProtKB/Swiss-Prot:P40403" /translation="MSIFNGIKEEQMDILREVGNIGAGHSASAMAQLLNRKIDMEVPF AKLLSFDELVDFFGGADVPVASIFLRMEGDLTGSMFFIMPFFQAEQFIRELIGNPDFD IEDLGEDHMSSSALHELGNILAGSYLTALADLTKLQLYPSVPEVSLDMFGAVISEGLM ELSQVGEHAIVVDTSIFDQSHQQELKAHMFMLPDYDSFEKLFVALGASL*" /label="cheC CDS" gene 1589165..1589794 /gene="cheC" /locus_tag="BSU_16450" /old_locus_tag="BSU16450" /label="cheC gene" CDS 1589791..1590291 /gene="cheD" /locus_tag="BSU_16460" /old_locus_tag="BSU16460" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15546616, 16469702, 22720735, 23226535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15546616, 16469702, 22720735, 23226535; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sequence specific deamidase required for methylation of methyl-accepting chemotaxis proteins (MCPs) by CheR" /protein_id="NP_389528.1" /db_xref="EnsemblGenomes-Gn:BSU16460" /db_xref="EnsemblGenomes-Tr:CAB13519" /db_xref="GOA:P40404" /db_xref="InterPro:IPR005659" /db_xref="InterPro:IPR011324" /db_xref="SubtiList:BG10750" /db_xref="UniProtKB/Swiss-Prot:P40404" /translation="MSTTEAVVIKVGIADVKIARFPDTIRTSGLGSCVGLVLYDKEKQ TAGLVHVMLPDSTLSKTAELNRAKYADTAVQTTIDMLIEAGCRKFALKAKLAGGSEMF KFKSTNDLMKIGPRNVLAIKEQLSLFNIPIISEDTGGSSGRTIEFEPKSCMLHIRTVK QGEKTI*" /label="cheD CDS" gene 1589791..1590291 /gene="cheD" /locus_tag="BSU_16460" /old_locus_tag="BSU16460" /label="cheD gene" CDS 1590314..1591078 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-28 factor (sigma-D)" /protein_id="NP_389529.1" /db_xref="EnsemblGenomes-Gn:BSU16470" /db_xref="EnsemblGenomes-Tr:CAB13520" /db_xref="GOA:P10726" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR012845" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10751" /db_xref="UniProtKB/Swiss-Prot:P10726" /translation="MQSLNYEDQVLWTRWKEWKDPKAGDDLMRRYMPLVTYHVGRISV GLPKSVHKDDLMSLGMLGLYDALEKFDPSRDLKFDTYASFRIRGAIIDGLRKEDWLPR TSREKTKKVEAAIEKLEQRYLRNVSPAEIAEELGMTVQDVVSTMNEGFFANLLSIDEK LHDQDDGENIQVMIRDDKNVPPEEKIMKDELIAQLAEKIHELSEKEQLVVSLFYKEEL TLTEIGQVLNLSTSRISQIHSKALFKLKNLLEKVIQ*" /label="sigD CDS" gene 1590314..1591078 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /label="sigD gene" promotor_-35 1591088..1591094 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" CDS 1591107..1591610 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15066026, 15175317, 19202088, 21736639, 26244495" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 15175317, 19202088, 21736639, 26244495; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling factor for flagellin transcription and translation" /protein_id="NP_389530.1" /db_xref="EnsemblGenomes-Gn:BSU16480" /db_xref="EnsemblGenomes-Tr:CAB13521" /db_xref="SubtiList:BG10752" /db_xref="UniProtKB/Swiss-Prot:P40405" /translation="MSTLLWLLSFMLHGVLLYAVIILYTRLAAVKETEKQQKQILEET ENTLAAFLLELKEENEKLIENKASSASQSDEESQKSGLQTSETYQERDPVQEAENLPE HIEGLITEVDRREELVNSEVQSFEDQVIELYEQGYSASQIAQKMKSGKTEIELFLKFR SKGVKDS*" /label="swrB CDS" gene 1591107..1591610 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /label="swrB gene" promotor_-10 1591109..1591120 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1591123 /Source="Nicolas_upshifts" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" promotor_-35 1591606..1591612 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1591627..1591646 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1591629..1591753 /Source="Nicolas_S_feature" /locus_tag="new_1717808_1717932" /HighExp="GM 45, GM 15, H2O2, M9-exp, LBGexp, C30, MG 90, GM-0.1, G135, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S586" upshifts 1591629 /Source="Nicolas_upshifts" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1591754..1592494 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9090122, 10675340, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S2" /protein_id="NP_389531.1" /db_xref="EnsemblGenomes-Gn:BSU16490" /db_xref="EnsemblGenomes-Tr:CAB13522" /db_xref="GOA:P21464" /db_xref="InterPro:IPR001865" /db_xref="InterPro:IPR005706" /db_xref="InterPro:IPR018130" /db_xref="InterPro:IPR023591" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19004" /db_xref="UniProtKB/Swiss-Prot:P21464" /translation="MSVISMKQLLEAGVHFGHQTRRWNPKMKRYIFTERNGIYIIDLQ KTVKKVEEAYNFTKNLAAEGGKILFVGTKKQAQDSVKEEAQRSGMYYVNQRWLGGTLT NFETIQKRIKRLKDIEKMQENGTFDVLPKKEVVQLKKELERLEKFLGGIKDMKDLPDA LFIIDPRKERIAVAEARKLNIPIIGIVDTNCDPDEIDVVIPANDDAIRAVKLLTSKMA DAILEAKQGEEEAEVAEETAPETETTTA*" /label="rpsB CDS" gene 1591754..1592494 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /label="rpsB gene" downshifts 1592476 /Source="Nicolas_upshifts" /id="D896" /incds=0 /nref=4 /ntot=61 /MaxReadThrough="9.04923" /MaxDrop="4.1312" /score="7.42766835" /energy="-14.3" /TU="U1324,U1328" /idTUdmin="U1323" /TUdmin=869 /isTUend="FALSE" /label="downshifts" S_feature 1592521..1592595 /Source="Nicolas_S_feature" /locus_tag="new_1718700_1718774" /HighExp="LPh, dia0, G150, G180, LBGexp, Lbexp, HPh, Oxctl, dia15, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S587" CDS 1592596..1593477 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6396082, 9244380, 9973356, 27624934; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor Ts" /protein_id="NP_389532.1" /db_xref="EnsemblGenomes-Gn:BSU16500" /db_xref="EnsemblGenomes-Tr:CAB13523" /db_xref="GOA:P80700" /db_xref="InterPro:IPR001816" /db_xref="InterPro:IPR009060" /db_xref="InterPro:IPR014039" /db_xref="InterPro:IPR018101" /db_xref="InterPro:IPR036402" /db_xref="SubtiList:BG19025" /db_xref="UniProtKB/Swiss-Prot:P80700" /translation="MAITAQQVKELREKTGAGMMDCKKALTETDGDMDKAIDLLREKG IAKAAKKADRIAAEGSTLIKTDGNKGVILEVNSETDFVAKNEGFKELLNTLADHLLAN TPADVEEAMGQKMENGSTVEEYITSAVAKIGEKITLRRFTVLTKDDSSAFGAYLHMGG RIGVLTVLNGTTDEETAKDIAMHVAAVNPRYISRDQVSEEETNHERQILTQQALQEGK PENIVAKMVEGRLNKFFEEICLLDQAFVKNPDEKVKQVIAAKNATVQTFVRYEVGEGI EKRQENFAEEVMNQVKK*" /label="tsf CDS" gene 1592596..1593477 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /label="tsf gene" S_feature 1593478..1593622 /Source="Nicolas_S_feature" /locus_tag="new_1719657_1719801" /HighExp="LBGexp, G150, LBGtran, G135, G180, LPh, Oxctl, dia0, Lbexp, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S588" CDS 1593623..1594345 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /EC_number="2.7.4.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9862121, 12682299, 12869195, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9862121, 12682299, 12869195, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridylate kinase" /protein_id="NP_389533.2" /db_xref="EnsemblGenomes-Gn:BSU16510" /db_xref="EnsemblGenomes-Tr:CAB13524" /db_xref="GOA:O31749" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR011817" /db_xref="InterPro:IPR015963" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12675" /db_xref="UniProtKB/Swiss-Prot:O31749" /translation="MEKPKYKRIVLKLSGEALAGEQGNGINPTVIQSIAKQVKEIAEL EVEVAVVVGGGNLWRGKTGSDLGMDRATADYMGMLATVMNSLALQDSLETLGIQSRVQ TSIEMRQVAEPYIRRKAIRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILM AKNNVDGVYNADPRKDESAVKYESLSYLDVLKDGLEVMDSTASSLCMDNDIPLIVFSI MEEGNIKRAVIGESIGTIVRGK*" /label="pyrH CDS" gene 1593623..1594345 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /label="pyrH gene" CDS 1594347..1594904 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9862121, 12480895, 12682299, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome recycling factor" /protein_id="NP_389534.1" /db_xref="EnsemblGenomes-Gn:BSU16520" /db_xref="EnsemblGenomes-Tr:CAB13525" /db_xref="GOA:P81101" /db_xref="InterPro:IPR002661" /db_xref="InterPro:IPR023584" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12587" /db_xref="UniProtKB/Swiss-Prot:P81101" /translation="MSKEVLTQTKEKMEKAIAAYQRELATVRAGRANPSLLDKVTVEY YGAQTPLNQLSSINVPEARMLVITPYDKTAIGDIEKAILKADLGLTPTSDGNMIRIAI PALTEERRKELVKVVKKYAEEAKVAVRNVRRDANDDLKKLEKNGDITEDELRASTEDV QKLTDEYVSKIDSVTKDKEKEIMEV*" /label="frr CDS" gene 1594347..1594904 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /label="frr gene" downshifts complement(1594851) /Source="Nicolas_upshifts" /id="D897" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="3.38183" /MaxDrop="3.17183" /score="-5.69560888" /energy="-4.8" /TU="NA" /idTUdmin="U1326" /TUdmin="-10739" /isTUend="FALSE" /label="downshifts" promotor_-35 1594893..1594896 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1594911..1594930 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1594929..1595034 /Source="Nicolas_S_feature" /locus_tag="new_1721108_1721213" /HighExp="G180, G135, T3.30H, Oxctl, G150, Cold, Paraq, C30, T3.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S589" upshifts 1594929 /Source="Nicolas_upshifts" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1595035..1595817 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /EC_number="2.5.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15788389, 16014871, 22904278, 23840410, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15788389, 16014871, 22904278, 23840410, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate synthase" /protein_id="NP_389535.1" /db_xref="EnsemblGenomes-Gn:BSU16530" /db_xref="EnsemblGenomes-Tr:CAB13526" /db_xref="GOA:O31751" /db_xref="InterPro:IPR001441" /db_xref="InterPro:IPR018520" /db_xref="InterPro:IPR036424" /db_xref="SubtiList:BG13408" /db_xref="UniProtKB/Swiss-Prot:O31751" /translation="MLNILKNWKNQQTAASNLERYTKEDILKGEIPEHIAIIMDGNGR WAKKRSLPRIAGHHEGMKVVKRTTKLANELGVKVLTLYAFSTENWKRPKMEVDFLMKL PEEFLNTYLPELVEENVQVRIIGDETALPAHTLRAIEKAVQDTAQNDGMILNFALNYG GRTEIVSAAKSLAEKVKEGSLNIEDIDESLFSTYLMTESLQDPELLIRTSGEIRLSNF MLWQVAYSEFVFTDVLWPDFKEDHFLQALGEFQQRGRRFGGI*" /label="uppS CDS" gene 1595035..1595817 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /label="uppS gene" CDS 1595821..1596630 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /EC_number="2.7.7.41" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 175832, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidate cytidylyltransferase (CDP-diglyceride synthase)" /protein_id="NP_389536.1" /db_xref="EnsemblGenomes-Gn:BSU16540" /db_xref="EnsemblGenomes-Tr:CAB13527" /db_xref="GOA:O31752" /db_xref="InterPro:IPR000374" /db_xref="SubtiList:BG12575" /db_xref="UniProtKB/Swiss-Prot:O31752" /translation="MVDMKQRILTGVLAAIVFLFLVIVGKLPFTILIYAMGSVALFEL LRMKKLKLVSLPGLIGLLLLWMFLLPSQYSFFEADGISKMEIALFAVLLLLTYTVLVK NTFTFDEVGFITLAAIYIGMCFHYFIEIRNLDQYGLTYIFYACVVIWSTDSGAYFVGK SLGKRKLWPEISPNKTVEGFAGGIVIALVLATIFQLVAQLPIPYIYLLLITLFLSVFG QLGDLVESALKRHYDVKDSGNILPGHGGILDRFDSFLFVMPFLYFLLALFS*" /label="cdsA" gene 1595821..1596630 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /label="cdsA gene" promotor_-35 1596611..1596618 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1596633..1596652 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1596634 /Source="Nicolas_upshifts" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1596692..1597843 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /EC_number="1.1.1.267" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15567415, 17458547, 21296950, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15567415, 17458547, 21296950, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-deoxy-D-xylulose-5-phosphate reductoisomerase" /protein_id="NP_389537.2" /db_xref="EnsemblGenomes-Gn:BSU16550" /db_xref="EnsemblGenomes-Tr:CAB13528" /db_xref="GOA:O31753" /db_xref="InterPro:IPR003821" /db_xref="InterPro:IPR013512" /db_xref="InterPro:IPR013644" /db_xref="InterPro:IPR026877" /db_xref="InterPro:IPR036169" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13409" /db_xref="UniProtKB/Swiss-Prot:O31753" /translation="MKNICLLGATGSIGEQTLDVLRAHQDQFQLVSMSFGRNIDKAVP MIEVFQPKFVSVGDLDTYHKLKQMSFSFECQIGLGEEGLIEAAVMEEVDIVVNALLGS VGLIPTLKAIEQKKTIALANKETLVTAGHIVKEHAKKYDVPLLPVDSEHSAIFQALQG EQAKNIERLIITASGGSFRDKTREELESVTVEDALKHPNWSMGAKITIDSATMMNKGL EVIEAHWLFDIPYEQIDVVLHKESIIHSMVEFHDKSVIAQLGTPDMRVPIQYALTYPD RLPLPDAKRLELWEIGSLHFEKADFDRFRCLQFAFESGKIGGTMPTVLNAANEVAVAA FLAGKIPFLAIEDCIEKALTRHQLLKKPSLADIQEVDKDTRGYVNSILT*" /label="dxr CDS" gene 1596692..1597843 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /label="dxr gene" CDS 1597850..1599118 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /EC_number="3.4.24.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inner membrane zinc metalloprotease required forthe extracytoplasmic stress response mediated by sigma(W)" /protein_id="NP_389538.1" /db_xref="EnsemblGenomes-Gn:BSU16560" /db_xref="EnsemblGenomes-Tr:CAB13529" /db_xref="GOA:O31754" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR004387" /db_xref="InterPro:IPR008915" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG13410" /db_xref="UniProtKB/Swiss-Prot:O31754" /translation="MFVNTVIAFIIIFGTLVFFHELGHLLLAQRAGILCREFAIGFGP KIFSFKKNETVYTIRLLPVGGFVRMAGEDPEMIEVKPGYTVGLLFNKEDQVEKVIINQ KEKYPDALVIEVETADLEHDMKITGYEQGKEDELSSFTVSETSFFIVDGEEVQIAPYN RQFGSKPVWQRIKAIAAGPIMNFILAYVILVMLGLIQGVPSNEPMLGQLTDNGRAAEA GLKEGDYIQSINGEKMRSWTDIVSAVKENPEKEMDVAVKRDNKTLHISVTPEAVKDEN KKTIGRFGSYAPTEKGVLSAVAYGATSTVDVTKAILTNLSKLVTGQFKLDMLSGPVGI YDMTDQVAKTGIVNLFQFAAFLSINLGIVNLLPIPALDGGRLLFLFIEAIRGKPINRE KEAFVVFIGVAFLMLLMLVVTWNDIQRLFL*" /label="rasP CDS" gene 1597850..1599118 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /label="rasP gene" CDS 1599151..1600845 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /EC_number="6.1.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16864571, 26886480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl-tRNA synthetase" /protein_id="NP_389539.1" /db_xref="EnsemblGenomes-Gn:BSU16570" /db_xref="EnsemblGenomes-Tr:CAB13530" /db_xref="GOA:O31755" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002316" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004500" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR023717" /db_xref="InterPro:IPR033730" /db_xref="InterPro:IPR036621" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12659" /db_xref="UniProtKB/Swiss-Prot:O31755" /translation="MRQSLTLIPTLREVPADAEAKSHQLLLRAGFIRQNTSGVYSYMP LAYKVIQNIQQIVREEMEKIDAVEMLMPALQQAETWQESGRWYTYGPELMRLKDRHGR EFALGATHEEVITSLVRDEVKSYKRLPLTLYQIQSKFRDEKRPRFGLLRGREFIMKDA YSFHASAESLDETYQKMYEAYSNIFARCGINVRPVIADSGAMGGKDTHEFMALSAIGE DTIAYSDESQYAANIEMAEVLHQEVPSDEEPKALEKVHTPNVKTIEELTAFLQVSAEA CIKSVLFKADDRFVLVLVRGDHEVNDIKVKNLLHAEVVELATHEEVIQQLGTEPGFVG PVGIHQDVEVYADQAVKAMVNAVAGANEGDHHYKNVNVNRDAQIKEFADLRFIKEGDP SPDGKGTIRFAEGIEVGQVFKLGTRYSEAMNATYLDENGRAQPMLMGCYGIGVSRTLS AIAEQHHDEKGLIWPKSVAPYDLHILALNMKNDGQRELAEKLYADLKAEGYEVLYDDR AERAGVKFADSDLIGLPIRITVGKRADEGIVEVKIRQTGESTEISVDELSAFISKQ*" /label="proS CDS" gene 1599151..1600845 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /label="proS gene" S_feature 1600846..1600953 /Source="Nicolas_S_feature" /locus_tag="new_1727025_1727132" /HighExp="G135, G180, G150, C30, Oxctl, H2O2, Paraq, LPh, LBGexp, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S590" CDS 1600954..1605267 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit)" /protein_id="NP_389540.1" /db_xref="EnsemblGenomes-Gn:BSU16580" /db_xref="EnsemblGenomes-Tr:CAB13531" /db_xref="GOA:P13267" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006308" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR024754" /db_xref="InterPro:IPR028112" /db_xref="InterPro:IPR029460" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG10263" /db_xref="UniProtKB/Swiss-Prot:P13267" /translation="MEQLSVNRRQFQILLQQINMTDDTFMTYFEHGEIKKLTIHKASK SWHFHFQFKSLLPFQIYDTLTTRLTQSFAHIAKVTSSIEVQDAEVSESIVQDYWSRCI EELQGISPPIISLLNQQKPKLKGNKLIVKTKTDTEAAALKNKYSSMIQAEYRQFGFPD LQLDAEIFVSEQEVQKFREQKLAEDQERAMQALIEMEKKDKESDEDQAPSGPLVIGYQ IKDNEEIRTLDSIMDEERRITVQGYVFDVETRELKSGRTLCIFKITDYTNSILIKMFA REKEDAALMKSLKKGMWVKARGSIQNDTFVRDLVMIANDVNEIKAKTREDSAPEGEKR VELHLHSPMSQMDAVTGIGKLVEQAKKWGHEAIALTDHAVVQSFPDAYSAAKKHGIKM IYGMEANLVDDGVPIAYNAAHRLLEEETYVVFDVETTGLSAVYDTIIELAAVKVKGGE IIDKFEAFANPHRPLSATIIELTGITDDMLQDAPDVVDVIRDFREWIGDDILVAHNAS FDMGFLNVAYKKLLEVEKAKNPVIDTLELGRFLYPEFKNHRLNTLCKKFDIELTQHHR AIYDTEATAYLLLKMLKDAAEKGIQYHDELNENMGQSNAYQRSRPYHATLLAVNSTGL KNLFKLVSLSHIHYFYRVPRIPRSQLEKYREGLLIGSACDRGEVFEGMMQKSPEEVED IASFYDYLEVQPPEVYRHLLELELVRDEKALKEIIANITKLGEKLNKPVVATGNVHYL NDEDKIYRKILISSQGGANPLNRHELPKVHFRTTDEMLEAFSFLGEEKAKEIVVTNTQ KVASLVDDIKPIKDDLYTPKIEGADEEIREMSYQRARSIYGEELPEIVEARIEKELKS IIGHGFAVIYLISHKLVKRSLDDGYLVGSRGSVGSSLVATLTEITEVNPLPPHYVCPE CQHSEFFNDGSVGSGFDLPDKTCPHCGTPLKKDGHDIPFETFLGFKGDKVPDIDLNFS GEYQPQAHNYTKVLFGEDNVYRAGTIGTVAEKTAYGYVKGYAGDNNLHMRGAEIDRLV QGCTGVKRTTGQHPGGIIVVPDYMDIYDFSPIQFPADATGSEWKTTHFDFHSIHDNLL KLDILGHDDPTVIRMLQDLSGIDPKTIPTDDPEVMKIFQGTESLGVTEEQIGCKTGTL GIPEFGTRFVRQMLEDTKPTTFSELVQISGLSHGTDVWLGNAQELIHNNICELSEVIG CRDDIMVYLIYQGLEPSLAFKIMEFVRKGKGLTPEWEEEMKNNNVPDWYIDSCKKIKY MFPKAHAAAYVLMAVRIAYFKVHHALLYYAAYFTVRADDFDIDTMIKGSTAIRAVMED INAKGLDASPKEKNLLTVLELALEMCERGYSFQKVDLYRSSATEFIIDGNSLIPPFNS IPGLGTNAALNIVKAREEGEFLSKEDLQKRGKVSKTILEYLDRHGCLESLPDQNQLSL F*" /label="polC CDS" gene 1600954..1605267 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /label="polC gene" S_feature 1605268..1605332 /Source="Nicolas_S_feature" /locus_tag="new_1731447_1731511" /HighExp="C30, G180, G135, Oxctl, G150, H2O2, Paraq, Cold, LBGstat, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S591" misc_RNA 1605278..1605495 /gene="surG" /locus_tag="BSU_misc_RNA_71" /product="small RNAs controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surG RNA" gene 1605278..1605495 /gene="surG" /locus_tag="BSU_misc_RNA_71" /label="surG gene" promotor_-35 1605304..1605310 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-35" promotor_-10 1605325..1605336 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-10" S_feature 1605334..1605401 /Source="Nicolas_S_feature" /locus_tag="new_1731513_1731580" /HighExp="S7, S5, S4, S8, S6, S3, G180, C30, T5.0H, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S592" upshifts 1605334 /Source="Nicolas_upshifts" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="upshifts" promotor_-35 1605384..1605390 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-35" S_feature 1605403..1605596 /Source="Nicolas_S_feature" /locus_tag="new_1731582_1731775" /HighExp="LoTm, Cold, HPh, G180, Paraq, Oxctl, T-5.40H, BMM, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S593" upshifts 1605403 /Source="Nicolas_upshifts" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="upshifts" promotor_-10 1605404..1605423 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-10" CDS 1605597..1606067 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15257761, 16014871, 19150615, 20188109, 21529161; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome maturation factor" /protein_id="NP_389541.1" /db_xref="EnsemblGenomes-Gn:BSU16590" /db_xref="EnsemblGenomes-Tr:CAB13532" /db_xref="GOA:P32726" /db_xref="InterPro:IPR003728" /db_xref="InterPro:IPR028989" /db_xref="InterPro:IPR028998" /db_xref="InterPro:IPR035956" /db_xref="InterPro:IPR036847" /db_xref="SubtiList:BG10264" /db_xref="UniProtKB/Swiss-Prot:P32726" /translation="MSKKVTDTVQEMAQPIVDSLQLELVDIEFVKEGQSWFLRVFIDS DDGVDIEECAKVSEALSEKLDEADPISQNYFLEVSSPGAERPLKKKADFEKSLGKNVY IKTYEPIDGVKVFEGELAEFDGQTVTVEITIKTRKKRINIPYEKIANARLAVTF*" /label="rimP CDS" gene 1605597..1606067 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /label="rimP gene" downshifts complement(1605918) /Source="Nicolas_upshifts" /id="D898" /incds=1 /nref=3 /ntot=136 /MaxReadThrough="2.08299" /MaxDrop="3.17419" /score="-8.18111474" /energy="-9.2" /TU="NA" /idTUdmin="U1333" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1606102..1607217 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15978071, 16707701, 16946247, 27571753, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15978071, 16707701, 16946247, 27571753, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="transcription translation coupling factor involved in Rho-dependent transcription termination" /protein_id="NP_389542.1" /db_xref="EnsemblGenomes-Gn:BSU16600" /db_xref="EnsemblGenomes-Tr:CAB13533" /db_xref="GOA:P32727" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR010213" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013735" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR025249" /db_xref="InterPro:IPR030842" /db_xref="InterPro:IPR036555" /db_xref="PDB:2MT4" /db_xref="SubtiList:BG10265" /db_xref="UniProtKB/Swiss-Prot:P32727" /translation="MSSELLDALTILEKEKGISKEIIIEAIEAALISAYKRNFNQAQN VRVDLNRETGSIRVFARKDVVDEVYDQRLEISIEEAQGIHPEYMVGDVVEIEVTPKDF GRIAAQTAKQVVTQRVREAERGVIYSEFIDREEDIMTGIVQRLDNKFIYVSLGKIEAL LPVNEQMPNESYKPHDRIKVYITKVEKTTKGPQIYVSRTHPGLLKRLFEIEVPEIYDG TVELKSVAREAGDRSKISVRTDDPDVDPVGSCVGPKGQRVQAIVNELKGEKIDIVNWS SDPVEFVANALSPSKVLDVIVNEEEKATTVIVPDYQLSLAIGKRGQNARLAAKLTGWK IDIKSETDARELGIYPRELEEDDEPLFTEPETAESDE*" /label="nusA CDS" gene 1606102..1607217 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /label="nusA gene" promotor_no_box complement(1606164..1606264) /Source="Nicolas_upshift_promotors" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1606204) /Source="Nicolas_upshifts" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1607231..1607506 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11679764, 12682299, 26771646, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular ruler co-factor for RNA; new fold" /protein_id="NP_389543.1" /db_xref="EnsemblGenomes-Gn:BSU16610" /db_xref="EnsemblGenomes-Tr:CAB13534" /db_xref="InterPro:IPR007393" /db_xref="InterPro:IPR035931" /db_xref="SubtiList:BG10266" /db_xref="UniProtKB/Swiss-Prot:P32728" /translation="MNKHKKIPLRKCVVTGEMKPKKELIRVVRSKEGEISVDPTGKKN GRGAYLTLDKECILAAKKKNTLQNQFQSQIDDQIFDELLELAEKVKK*" /label="rulR CDS" gene 1607231..1607506 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /label="rulR gene" CDS 1607508..1607810 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15130481, 15361074, 22355167, 26522935, 26771646" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130481, 15361074, 22355167, 26522935, 26771646; Product type f: factor" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein" /protein_id="NP_389544.1" /db_xref="EnsemblGenomes-Gn:BSU16620" /db_xref="EnsemblGenomes-Tr:CAB13535" /db_xref="GOA:P32729" /db_xref="InterPro:IPR004037" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7Q" /db_xref="SubtiList:BG10267" /db_xref="UniProtKB/Swiss-Prot:P32729" /translation="MSGMEWFPLLGLANRARKVVSGEDLVIKEIRNARAKLVLLTEDA SSNTAKKVTDKCNYYKVPYKKVESRAVLGRSIGKEARVVVAVTDQGFANKLISLLD*" /label="rulQ CDS" gene 1607508..1607810 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /label="rulQ gene" CDS 1607830..1609980 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1426242, 9588797, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1426242, 9588797, 12682299, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-2" /protein_id="NP_389545.1" /db_xref="EnsemblGenomes-Gn:BSU16630" /db_xref="EnsemblGenomes-Tr:CAB13536" /db_xref="GOA:P17889" /db_xref="InterPro:IPR000178" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006847" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR015760" /db_xref="InterPro:IPR023115" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036925" /db_xref="SubtiList:BG10268" /db_xref="UniProtKB/Swiss-Prot:P17889" /translation="MAKMRVYEYAKALNVSSKEILTALKNMDLEVNNHMAMLEEKAIK KLDAKYKKGGAAAKSQKPAETNKNKQPQGVNQQSAGNQPNKIRDGKKNDVQNNQFNKN KKNNNNKKNKRNNNNNKNQHQQKPVKPKKELPEKITFSGTLTVGALAEELGKEPSELI KKLMLLGVMATINQELDKDTIELIASEYGVETEEVIVLEETELEKYEEPDNEEDLEIR PPVVTIMGHVDHGKTTLLDSIRKTKVVEGEAGGITQHIGAYQIEENGKKITFLDTPGH AAFTTMRARGAEVTDITILVVAADDGVMPQTVEAINHAKAAEVPIIVAVNKIDKESAN PDRVMQELTEYGLVPEAWGGETIFVPLSALTGKGIDELVEMILLVSEVEELKANPNRQ AKGTVIEAELDKGRGSVATLLVQTGTLHVGDPIVVGNTFGRVRAMVNDIGRRVKTAGP STPVEITGLNDVPQAGDQFLVFKDEKTARSVGEARASKQLEEQRSDKAKLSLDDLFEQ IKQGDVKDINLIVKADVQGSAEALTAALQKIEVEGVKVKIIHTGVGAITESDIILASA SNAIVIGFNVRPDGNAKSTAEAENVDIRLHRIIYKVIDEIEAAMKGMLDPEYEEKVIG QVEVRQTFKVSKIGTIAGGYVTEGTITRDSGLRLIRDGVVIFEGEVDVLKRFKDDVKE VSQGYECGITIKKYNDIREGDILEAFVMQEIERT*" /label="infB CDS" gene 1607830..1609980 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /label="infB gene" promotor_-35 1609875..1609881 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1609890 /Source="Nicolas_upshifts" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1609896..1609914 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1609977..1610255 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of conserved protein" /db_xref="EnsemblGenomes-Gn:BSU16640" /db_xref="EnsemblGenomes-Tr:CAB13537" /db_xref="InterPro:IPR007546" /db_xref="InterPro:IPR036746" /db_xref="PSEUDO:CAB13537.1" /db_xref="SubtiList:BG10269" /db_xref="UniProtKB/Swiss-Prot:P32730" /translation="MIGFAECECIIYDAGSLKEKRAVLKRILTRVQNKFNVSISEIGY QDTWQRTSFGIAAVSSSRVQTEKELQRVLAFIDSFPEIERTITRTEWF*" /label="ylxP CDS" gene 1609977..1610255 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /pseudo /label="ylxP gene" CDS 1610272..1610625 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12628255, 15185964, 17996707, 21102555, 21529161, 23293003, 23611982, 24671761, 25904134, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="pre-ribosomal (17S) RNA binding factor A" /protein_id="NP_389547.1" /db_xref="EnsemblGenomes-Gn:BSU16650" /db_xref="EnsemblGenomes-Tr:CAB13538" /db_xref="GOA:P32731" /db_xref="InterPro:IPR000238" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020053" /db_xref="InterPro:IPR023799" /db_xref="SubtiList:BG10270" /db_xref="UniProtKB/Swiss-Prot:P32731" /translation="MSMRANRVGEQMKKELGDIISRKLKDPRIGFLTVTDVRVSGDLQ IAKVYISVLGDEKKREEALKGLAKAKGFIRSEIGSRIRLRKTPEIEFEFDESIDYGNR IETLIHELHSEKPSE*" /label="rbfA CDS" gene 1610272..1610625 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /label="rbfA gene" downshifts 1610616 /Source="Nicolas_upshifts" /id="D899" /incds=0 /nref=9 /ntot=130 /MaxReadThrough="6.97196" /MaxDrop="5.80207" /score="-3.06560848" /energy="-13.8" /TU="U1331,U1332,U1334" /idTUdmin="U1331" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" CDS 1610707..1611636 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /EC_number="5.4.99.25" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7489483, 15987897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine 55 synthase" /protein_id="NP_389548.1" /db_xref="EnsemblGenomes-Gn:BSU16660" /db_xref="EnsemblGenomes-Tr:CAB13539" /db_xref="GOA:P32732" /db_xref="InterPro:IPR002501" /db_xref="InterPro:IPR014780" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR032819" /db_xref="SubtiList:BG10271" /db_xref="UniProtKB/Swiss-Prot:P32732" /translation="MVNGVLLLHKPVGMTSHDCVMKIRKLLKTKKVGHTGTLDPEVSG VLPICVGRATKIVEYLTEKSKTYDAEITLGFSTTTEDQTGETVETKPVNHDIDKADVE KVLNSLKGKQEQIPPMYSAVKVNGKKLYEYARAGIEVERPKRMITIEDIALTTEIKHH GETASFRFTVTCSKGTYVRTLAVMIGEKLGYPAHMSHLIRTASGDFSLDECFTFDELE AQAQSGTVEEHTVPIERALNHLPKWIISDTLAKKVENGALLETPEQFSEMTSGDRIAV FTESGTCLAIYFPHPAKKGLLKPAKVLMQKSEQ*" /label="truB CDS" gene 1610707..1611636 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /label="truB gene" promotor_-35 1611421..1611428 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1611442..1611461 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1611451 /Source="Nicolas_upshifts" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1611655..1612605 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /EC_number="2.7.1.26" /EC_number="2.7.7.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9473052, 10206712, 12456892, 15668000, 18156273, 21866869" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9473052, 10206712, 12456892, 15668000, 18156273, 21866869; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="bifunctional riboflavin kinase FAD synthase" /protein_id="NP_389549.1" /db_xref="EnsemblGenomes-Gn:BSU16670" /db_xref="EnsemblGenomes-Tr:CAB13540" /db_xref="GOA:P54575" /db_xref="InterPro:IPR002606" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015864" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11495" /db_xref="UniProtKB/Swiss-Prot:P54575" /translation="MKTIHITHPHHLIKEEQAKSVMALGYFDGVHLGHQKVIGTAKQI AEEKGLTLAVMTFHPHPSHVLGRDKEPKDLITPLEDKINQIEQLGTEVLYVVKFNEVF ASLSPKQFIDQYIIGLNVQHAVAGFDFTYGKYGKGTMKTMPDDLDGKAGCTMVEKLTE QDKKISSSYIRTALQNGDVELANVLLGQPYFIKGIVIHGDKRGRTIGFPTANVGLNNS YIVPPTGVYAVKAEVNGEVYNGVCNIGYKPTFYEKRPEQPSIEVNLFDFNQEVYGAAI KIEWYKRIRSERKFNGIKELTEQIEKDKQEAIRYFSNLRK*" /label="ribC CDS" gene 1611655..1612605 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /label="ribC gene" promotor_-35 1612638..1612644 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1612645..1612761 /Source="Nicolas_S_feature" /locus_tag="new_1738824_1738940" /HighExp="SMM, GM 15, Salt, T-4.40H, GM 45, T-5.40H, GM 60, MG 45, LPhT, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S594" upshifts 1612645 /Source="Nicolas_upshifts" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1612659..1612678 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1612762..1613031 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15627386, 8825778, 20418391, 22720735, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15627386, 8825778, 20418391, 22720735, 23611891; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S15 (BS18)" /protein_id="NP_389550.1" /db_xref="EnsemblGenomes-Gn:BSU16680" /db_xref="EnsemblGenomes-Tr:CAB13541" /db_xref="GOA:P21473" /db_xref="InterPro:IPR000589" /db_xref="InterPro:IPR005290" /db_xref="InterPro:IPR009068" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19010" /db_xref="UniProtKB/Swiss-Prot:P21473" /translation="MAITQERKNQLINEFKTHESDTGSPEVQIAILTDSINNLNEHLR THKKDHHSRRGLLKMVGKRRNLLTYLRNKDVTRYRELINKLGLRR*" /label="rpsO CDS" gene 1612762..1613031 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /label="rpsO gene" downshifts 1613014 /Source="Nicolas_upshifts" /id="D900" /incds=0 /nref=30 /ntot=154 /MaxReadThrough="8.65904" /MaxDrop="5.6648" /score="29.9198852" /energy="-10.2" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1331" /TUdmin=2090 /isTUend="FALSE" /label="downshifts" S_feature 1613059..1613144 /Source="Nicolas_S_feature" /locus_tag="new_1739238_1739323" /HighExp="Cold, LoTm, Oxctl, G180, H2O2, G150, dia15, Paraq, LPh, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S595" promotor_-35 1613125..1613128 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1613144..1613163 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1613146 /Source="Nicolas_upshifts" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1613204..1615321 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /EC_number="2.7.7.8" /EC_number="3.1.13.1" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polynucleotide phosphorylase (PNPase)" /protein_id="NP_389551.1" /db_xref="EnsemblGenomes-Gn:BSU16690" /db_xref="EnsemblGenomes-Tr:CAB13542" /db_xref="GOA:P50849" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR012162" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR015848" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="InterPro:IPR036456" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG11491" /db_xref="UniProtKB/Swiss-Prot:P50849" /translation="MGQEKHVFTIDWAGRTLTVETGQLAKQANGAVMIRYGDTAVLST ATASKEPKPLDFFPLTVNYEERLYAVGKIPGGFIKREGRPSEKAVLASRLIDRPIRPL FADGFRNEVQVISIVMSVDQNCSSEMAAMFGSSLALSVSDIPFEGPIAGVTVGRIDDQ FIINPTVDQLEKSDINLVVAGTKDAINMVEAGADEVPEEIMLEAIMFGHEEIKRLIAF QEEIVAAVGKEKSEIKLFEIDEELNEKVKALAEEDLLKAIQVHEKHAREDAINEVKNA VVAKFEDEEHDEDTIKQVKQILSKLVKNEVRRLITEEKVRPDGRGVDQIRPLSSEVGL LPRTHGSGLFTRGQTQALSVCTLGALGDVQILDGLGVEESKRFMHHYNFPQFSVGETG PMRGPGRREIGHGALGERALEPVIPSEKDFPYTVRLVSEVLESNGSTSQASICASTLA MMDAGVPIKAPVAGIAMGLVKSGEHYTVLTDIQGMEDALGDMDFKVAGTEKGVTALQM DIKIEGLSREILEEALQQAKKGRMEILNSMLATLSESRKELSRYAPKILTMTINPDKI RDVIGPSGKQINKIIEETGVKIDIEQDGTIFISSTDESGNQKAKKIIEDLVREVEVGQ LYLGKVKRIEKFGAFVEIFSGKDGLVHISELALERVGKVEDVVKIGDEILVKVTEIDK QGRVNLSRKAVLREEKEKEEQQS*" /label="pnpA CDS" gene 1613204..1615321 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /label="pnpA gene" downshifts 1615104 /Source="Nicolas_upshifts" /id="D901" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.05841" /MaxDrop="3.82025" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336,U1337" /idTUdmin="U1337" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" downshifts 1615305 /Source="Nicolas_upshifts" /id="D902" /incds=0 /nref=192 /ntot=270 /MaxReadThrough="5.61214" /MaxDrop="6.82185" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1337" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature 1615350..1615438 /Source="Nicolas_S_feature" /locus_tag="new_1741529_1741617" /HighExp="G135, G180, G150, H2O2, Oxctl, LBGexp, Paraq, LoTm, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S596" CDS 1615439..1616398 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14679227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar deacetylase" /protein_id="NP_389552.1" /db_xref="EnsemblGenomes-Gn:BSU16700" /db_xref="EnsemblGenomes-Tr:CAB13543" /db_xref="GOA:P50850" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR010916" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014228" /db_xref="SubtiList:BG11492" /db_xref="UniProtKB/Swiss-Prot:P50850" /translation="MYKKFVPFAVFLFLFFVSFEMMENPHALDYIGAMKKDTVTVTAS KDPLYEELLQKAPEYEVKPQNARIDKVWKSIPGYNGLKVNIEQSYKKMKQHGKFREKD LVYSQVKPSVHLESLQPEPIYKGNPDKPMVAFLINVAWGNEYLEKMLPILQKHQVKAT FFLEGNWVRNNVQLAKKIAKDGHEIGNHSYNHPDMSKLTTGRISEQLDKTNEQIEQTI GVKPKWFAPPSGSFRKAVIDIAAEKQMGTVMWTVDTIDWQKPAPSVLQTRVLSKIHNG AMILMHPTDPTAESLEALITQIKDKGYALGTVTELMDETRLLK*" /label="ylxY CDS" gene 1615439..1616398 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /label="ylxY gene" promotor_-10 complement(1615507..1615515) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1615510) /Source="Nicolas_upshifts" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1615529..1615536) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1616002..1616007 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1616023..1616041 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1616028 /Source="Nicolas_upshifts" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1616438..1617667 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10666719, 10974125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666719, 10974125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="specific processing protease" /protein_id="NP_389553.2" /db_xref="EnsemblGenomes-Gn:BSU16710" /db_xref="EnsemblGenomes-Tr:CAB13544" /db_xref="GOA:Q04805" /db_xref="InterPro:IPR001431" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG10779" /db_xref="UniProtKB/Swiss-Prot:Q04805" /translation="MIKRYTCQNGVRIVLENNPTVRSVAIGVWIGTGSRHETPEINGI SHFLEHMFFKGTSTKSAREIAESFDRIGGQVNAFTSKEYTCYYAKVLDEHANYALDVL ADMFFHSTFDENELKKEKNVVYEEIKMYEDAPDDIVHDLLSKATYGNHSLGYPILGTE ETLASFNGDSLRQYMHDYYTPDRVVISVAGNISDSFIKDVEKWFGSYEAKGKATGLEK PEFHTEKLTRKKETEQAHLCLGFKGLEVGHERIYDLIVLNNVLGGSMSSRLFQDVRED KGLAYSVYSYHSSYEDSGMLTIYGGTGANQLQQLSETIQETLATLKRDGITSKELENS KEQMKGSLMLSLESTNSKMSRNGKNELLLGKHKTLDEIINELNAVNLERVNGLARQLF TEDYALALISPSGNMPS*" /label="mlpA CDS" gene 1616438..1617667 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /label="mlpA gene" downshifts 1617656 /Source="Nicolas_upshifts" /id="D903" /incds=0 /nref=140 /ntot=219 /MaxReadThrough="1.31218" /MaxDrop="4.84427" /score="15.1952611" /energy="-12.6" /TU="NA" /idTUdmin="U1336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1617696..1617701 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1617711 /Source="Nicolas_upshifts" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1617717..1617735 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1617745..1618002 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /experiment="publication(s) with functional evidences, PMID:23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="PRC barrel protein involved in sporulation" /protein_id="NP_389554.1" /db_xref="EnsemblGenomes-Gn:BSU16720" /db_xref="EnsemblGenomes-Tr:CAB13545" /db_xref="GOA:Q04811" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG10780" /db_xref="UniProtKB/Swiss-Prot:Q04811" /translation="MRLSELSGKEIVDIKRAERLGVLGQTDLEINEQDGQITALLIPT VKWFGLRKQGHDIRVPWHHIQKIGSDMIILDVPEEMPPRQE*" /label="ymxH CDS" gene 1617745..1618002 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /label="ymxH gene" S_feature 1618003..1618057 /Source="Nicolas_S_feature" /locus_tag="new_1744182_1744236" /HighExp="S4, S3, S5, S6, S8, S7, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S597" downshifts 1618030 /Source="Nicolas_upshifts" /id="D904" /incds=0 /nref=41 /ntot=56 /MaxReadThrough="0.534319999999999" /MaxDrop="6.36032" /score="29.434739" /energy="-11.7" /TU="NA" /idTUdmin="U1340" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1618099..1618108 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-35" S_feature 1618118..1618187 /Source="Nicolas_S_feature" /locus_tag="new_1744297_1744366" /HighExp="S6, S8, S7, BT, B36, S5, G/S, Pyr, B60, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S598" upshifts 1618118 /Source="Nicolas_upshifts" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="upshifts" promotor_-10 1618122..1618141 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-10" CDS 1618188..1619081 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /EC_number="1.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit A" /protein_id="NP_389555.1" /db_xref="EnsemblGenomes-Gn:BSU16730" /db_xref="EnsemblGenomes-Tr:CAB13546" /db_xref="GOA:Q04809" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR014215" /db_xref="InterPro:IPR031629" /db_xref="InterPro:IPR036291" /db_xref="PDB:2RIR" /db_xref="SubtiList:BG10781" /db_xref="UniProtKB/Swiss-Prot:Q04809" /translation="MLTGLKIAVIGGDARQLEIIRKLTEQQADIYLVGFDQLDHGFTG AVKCNIDEIPFQQIDSIILPVSATTGEGVVSTVFSNEEVVLKQDHLDRTPAHCVIFSG ISNAYLENIAAQAKRKLVKLFERDDIAIYNSIPTVEGTIMLAIQHTDYTIHGSQVAVL GLGRTGMTIARTFAALGANVKVGARSSAHLARITEMGLVPFHTDELKEHVKDIDICIN TIPSMILNQTVLSSMTPKTLILDLASRPGGTDFKYAEKQGIKALLAPGLPGIVAPKTA GQILANVLSKLLAEIQAEEGK*" /label="spoVFA CDS" gene 1618188..1619081 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /label="spoVFA gene" CDS 1619084..1619686 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit B" /protein_id="NP_389556.1" /db_xref="EnsemblGenomes-Gn:BSU16740" /db_xref="EnsemblGenomes-Tr:CAB13547" /db_xref="GOA:Q04810" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR014214" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG10782" /db_xref="UniProtKB/Swiss-Prot:Q04810" /translation="MSSLKGKRIGFGLTGSHCTYEAVFPQIEELVNEGAEVRPVVTFN VKSTNTRFGEGAEWVKKIEDLTGYEAIDSIVKAEPLGPKLPLDCMVIAPLTGNSMSKL ANAMTDSPVLMAAKATIRNNRPVVLGISTNDALGLNGTNLMRLMSTKNIFFIPFGQDD PFKKPNSMVAKMDLLPQTIEKALMHQQLQPILVENYQGND*" /label="spoVFB CDS" gene 1619084..1619686 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /label="spoVFB gene" misc_feature 1619740..1619759 /Source="Nicolas_upshift_promotors" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1619740..1619811 /Source="Nicolas_S_feature" /locus_tag="new_1745919_1745990" /HighExp="S6, S7, S8, C90, S5, BT, MG 45, MG 5, SMM, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S599" upshifts 1619740 /Source="Nicolas_upshifts" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1619812..1620852 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /EC_number="1.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 12682299, 25355936, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 12682299, 25355936, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate-semialdehyde dehydrogenase" /protein_id="NP_389557.1" /db_xref="EnsemblGenomes-Gn:BSU16750" /db_xref="EnsemblGenomes-Tr:CAB13548" /db_xref="GOA:Q04797" /db_xref="InterPro:IPR000319" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR005986" /db_xref="InterPro:IPR012080" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10783" /db_xref="UniProtKB/Swiss-Prot:Q04797" /translation="MGRGLHVAVVGATGAVGQQMLKTLEDRNFEMDTLTLLSSKRSAG TKVTFKGQELTVQEASPESFEGVNIALFSAGGSVSQALAPEAVKRGAIVIDNTSAFRM DENTPLVVPEVNEADLHEHNGIIANPNCSTIQMVAALEPIRKAYGLNKVIVSTYQAVS GAGNEAVKELYSQTQAILNKEEIEPEIMPVKGDKKHYQIAFNAIPQIDKFQDNGYTFE EMKMINETKKIMHMPDLQVAATCVRLPIQTGHSESVYIEIDRDDATVEDIKNLLKEAP GVTLQDDPSQQLYPMPADAVGKNDVFVGRIRKDLDRANGFHLWVVSDNLLKGAAWNSV QIAESLKKLNLV*" /label="asd CDS" gene 1619812..1620852 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /label="asd gene" S_feature 1620853..1620943 /Source="Nicolas_S_feature" /locus_tag="new_1747032_1747122" /HighExp="S7, S6, S8, LBGtran, GM 120, dia15, Heat, LBGstat, GM 90, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S600" CDS 1620944..1622158 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1906928, 8098035" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906928, 8098035; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase I (alpha and beta subunits)" /protein_id="NP_389558.2" /db_xref="EnsemblGenomes-Gn:BSU16760" /db_xref="EnsemblGenomes-Tr:CAB13549" /db_xref="GOA:Q04795" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10784" /db_xref="UniProtKB/Swiss-Prot:Q04795" /translation="MKIIVQKFGGTSVKDDKGRKLALGHIKEAISEGYKVVVVVSAMG RKGDPYATDSLLGLLYGDQSAISPREQDLLLSCGETISSVVFTSMLLDNGVKAAALTG AQAGFLTNDQHTNAKIIEMKPERLFSVLANHDAVVVAGFQGATEKGDTTTIGRGGSDT SAAALGAAVDAEYIDIFTDVEGVMTADPRVVENAKPLPVVTYTEICNLAYQGAKVISP RAVEIAMQAKVPIRVRSTYSNDKGTLVTSHHSSKVGSDVFERLITGIAHVKDVTQFKV PAKIGQYNVQTEVFKAMANAGISVDFFNITPSEIVYTVAGNKTETAQRILMDMGYDPM VTRNCAKVSAVGAGIMGVPGVTSKIVSALSEKEIPILQSADSHTTIWVLVHEADMVPA VNALHEVFELSK*" /label="dapG CDS" gene 1620944..1622158 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /label="dapG gene" CDS 1622189..1623061 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /EC_number="4.3.3.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 9298659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 9298659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-tetrahydrodipicolinate synthase" /protein_id="NP_389559.1" /db_xref="EnsemblGenomes-Gn:BSU16770" /db_xref="EnsemblGenomes-Tr:CAB13550" /db_xref="GOA:Q04796" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR005263" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020624" /db_xref="InterPro:IPR020625" /db_xref="SubtiList:BG10785" /db_xref="UniProtKB/Swiss-Prot:Q04796" /translation="MNFGNVSTAMITPFDNKGNVDFQKLSTLIDYLLKNGTDSLVVAG TTGESPTLSTEEKIALFEYTVKEVNGRVPVIAGTGSNNTKDSIKLTKKAEEAGVDAVM LVTPYYNKPSQEGMYQHFKAIAAETSLPVMLYNVPGRTVASLAPETTIRLAADIPNVV AIKEASGDLEAITKIIAETPEDFYVYSGDDALTLPILSVGGRGVVSVASHIAGTDMQQ MIKNYTNGQTANAALIHQKLLPIMKELFKAPNPAPVKTALQLRGLDVGSVRLPLVPLT EDERLSLSSTISEL*" /label="dapA CDS" gene 1622189..1623061 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /label="dapA gene" S_feature complement(1622532..1623716) /Source="Nicolas_S_feature" /locus_tag="new_1748711_1749895_c" /HighExp="S8, S6, S4, S5, S7, S3, LoTm, T5.0H, BT, C30" /AntisenseName="dapA" /AntisenseCor="0.13444126275526899" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S601" downshifts 1623068 /Source="Nicolas_upshifts" /id="D905" /incds=0 /nref=17 /ntot=99 /MaxReadThrough="6.0497" /MaxDrop="5.05122" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1341" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1623161..1623164 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1623178 /Source="Nicolas_upshifts" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1623180..1623199 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1623239..1624906 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual activity 5' exo-and endoribonuclease J2" /protein_id="NP_389560.2" /db_xref="EnsemblGenomes-Gn:BSU16780" /db_xref="EnsemblGenomes-Tr:CAB13551" /db_xref="GOA:O31760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13422" /db_xref="UniProtKB/Swiss-Prot:O31760" /translation="MKKKNTENVRIIALGGVGEIGKNLYVIEIDSDIFVVDAGLMHPE NEMLGIDVVIPDISYLIERADRVKAIFLTHGHDENIGGVFYLLNKLSVPVYGTKLTLA LLREKLKQYGHNRKTDLREIHSKSVITFESTKVSFFRTIHSIPDSVGVSFKTSLGSIV CTGDFKFDQTPALNQTCDIGEIAKIGNSGVLALLSDSANAERPGYTPSEAAVSGEISD ALYNSQNRVIIAVFASNINRIQQVIHAAAQNGRKIAVAGKNLQSVLQLARKLGYIEAD DELFISVQDVKKYPKREVAIITAGSQGEPLAALTRMANKAHKQLNIEEGDTVVIASTP IPGQELIYSKTVDLLARAGAQVIFAQKRVHVSGHGSQEELKLMINLLKPKYLIPVNGE YRMQKAHSKIAEETGMKRSDIFLIEKGDVVEFRGQNVKIGDKVPYGNILIDGLGVGDI GNIVLRDRRLLSQDGILIVVITLDKQKKHLVSGPEIITRGFVYVRESEGLIVQATELV RSIVTEATETSNVEWSTLKQAMRDALNQFLYEKTKRKPMIIPIIMEV*" /label="rnjB CDS" gene 1623239..1624906 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /label="rnjB gene" promotor_-10 complement(1623703..1623721) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1623720) /Source="Nicolas_upshifts" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1623737..1623742) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1624894 /Source="Nicolas_upshifts" /id="D906" /incds=0 /nref=227 /ntot=263 /MaxReadThrough="4.0072" /MaxDrop="6.75416" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1343" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1624961..1624967 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-35" promotor_-10 1624981..1624992 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-10" upshifts 1624982 /Source="Nicolas_upshifts" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="upshifts" CDS 1625022..1625759 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10455123, 15189290, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455123, 15189290, 23927687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein export-enhancing protease (spore outgrowth)" /protein_id="NP_389561.3" /db_xref="EnsemblGenomes-Gn:BSU16790" /db_xref="EnsemblGenomes-Tr:CAB13552" /db_xref="GOA:Q99171" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11055" /db_xref="UniProtKB/Swiss-Prot:Q99171" /translation="MDHRMENTEEERPEKNDAKDSIMNKIQQLGETTLPQLPQDTNIH CLTIIGQIEGHVQLPPQNKTTKYEHVIPQIVAIEQNPKIEGLLIILNTVGGDVEAGLA IAEMLASLSKPTVSIVLGGGHSIGVPIAVSCDYSYIAETATMTIHPVRLTGLVIGVPQ TFEYLDKMQERVVKFVTSHSNITEEKFKELMFSKGNLTRDIGTNVVGKDAVKYGLIDH AGGVGQAINKLNELIDEARKEEGRMIQ*" /label="tepA CDS" gene 1625022..1625759 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /label="tepA gene" CDS 1625756..1625968 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23927687; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of TepA activity (spore outgrowth)" /protein_id="YP_003097729.1" /db_xref="EnsemblGenomes-Gn:BSU16799" /db_xref="EnsemblGenomes-Tr:CAX52620" /db_xref="InterPro:IPR025619" /db_xref="UniProtKB/Swiss-Prot:C0H413" /translation="MILYTVMPQEIVFAEQNQETSAHEQIEYKGVPLLVEMKGNEAEV IQIMSTNPMHFLHPDISPGQKLKLNV*" /label="tepJ CDS" gene 1625756..1625968 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /label="tepJ gene" misc_feature 1625996..1626015 /Source="Nicolas_upshift_promotors" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1626010 /Source="Nicolas_upshifts" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="upshifts" CDS 1626099..1628462 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11062134, 11778051, 12618465, 16430687, 17139259, 17322320, 18160039, 24297254, 24769697, 26452092; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore DNA directional translocase (motor ATPase)" /protein_id="NP_389562.3" /db_xref="EnsemblGenomes-Gn:BSU16800" /db_xref="EnsemblGenomes-Tr:CAB13553" /db_xref="GOA:P21458" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10763" /db_xref="UniProtKB/Swiss-Prot:P21458" /translation="MAKKKRKSRKKQAKQLNIKYELNGLLCIAISIIAILQLGVVGQT FIYLFRFFAGEWFILCLLGLLVLGVSLFWKKKTPSLLTRRKAGLYCIIASILLLSHVQ LFKNLTHKGSIESASVVRNTWELFLMDMNGSSASPDLGGGMIGALLFAASHFLFASTG SQIMAIVMILIGMILVTGRSLQETLKKWMSPIGRFIKEQWLAFIDDMKSFKSNMQSSK KTKAPSKKQKPARKKQQMEPEPPDEEGDYETVSPLIHSEPIISSFSDRNEEEESPVIE KRAEPVSKPLQDIQPETGDQETVSAPPMTFTELENKDYEMPSLDLLADPKHTGQQADK KNIYENARKLERTFQSFGVKAKVTQVHLGPAVTKYEVYPDVGVKVSKIVNLSDDLALA LAAKDIRIEAPIPGKSAIGIEVPNAEVAMVSLKEVLESKLNDRPDAKLLIGLGRNISG EAVLAELNKMPHLLVAGATGSGKSVCVNGIITSILMRAKPHEVKMMMIDPKMVELNVY NGIPHLLAPVVTDPKKASQALKKVVNEMERRYELFSHTGTRNIEGYNDYIKRANNEEG AKQPELPYIVVIVDELADLMMVASSDVEDSITRLSQMARAAGIHLIIATQRPSVDVIT GVIKANIPSRIAFSVSSQTDSRTILDMGGAEKLLGRGDMLFLPVGANKPVRVQGAFLS DDEVEKVVDHVITQQKAQYQEEMIPEETTETHSEVTDELYDEAVELIVGMQTASVSML QRRFRIGYTRAARLIDAMEERGVVGPYEGSKPREVLLSKEKYDELSS*" /label="spoIIIE CDS" gene 1626099..1628462 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /label="spoIIIE gene" S_feature 1628463..1628563 /Source="Nicolas_S_feature" /locus_tag="new_1754642_1754742" /HighExp="Cold, C30, G135, Lbstat, BC, G180, G150, S8, LoTm, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.109246" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S602" promotor_-35 1628524..1628531 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1628546..1628565 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1628564 /Source="Nicolas_upshifts" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="upshifts" CDS 1628606..1629331 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family,possibly involved in biofilm formation)" /protein_id="NP_389563.1" /db_xref="EnsemblGenomes-Gn:BSU16810" /db_xref="EnsemblGenomes-Tr:CAB13554" /db_xref="GOA:O31761" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13423" /db_xref="UniProtKB/Swiss-Prot:O31761" /translation="MSTKADNRHLYLKVIERIKEDIKNGIYTEKEKLPSEFELSKKLG VSRATLREALRILEEEHVIIRRHGVGTFVHSKPLFLSGIEQLNSVTKMIEQANMTPGT IFLSSQVLMPSEDDTKRFHLAEGQELFYLERVRTADGQPIVYCIDKIPMNILPNSFSH QQESMFDLLEKNSGSVISYAVTDIEPIGYHDTISPVLECDPETALLLLKQTHYDQHDK PVLYSLNYFRADKFRFHVLRKRF*" /label="ymfC CDS" gene 1628606..1629331 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /label="ymfC gene" downshifts 1629318 /Source="Nicolas_upshifts" /id="D907" /incds=0 /nref=135 /ntot=256 /MaxReadThrough="4.863" /MaxDrop="4.01593" /score="16.3235883" /energy="-7.2" /TU="U1346,U1347" /idTUdmin="U1346" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 1629387..1629393 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1629406 /Source="Nicolas_upshifts" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1629408..1629419 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1629470..1630678 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /function="7: Transport and binding proteins" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18502870, 27375568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18502870, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacillibactin exporter" /protein_id="NP_389564.2" /db_xref="EnsemblGenomes-Gn:BSU16825" /db_xref="EnsemblGenomes-Tr:CAB13555" /db_xref="GOA:O31762" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13424" /db_xref="UniProtKB/Swiss-Prot:O31762" /translation="MKNIIALSSVPLVMTLGNSMLIPVLPMMEKKLSVTSFQVSLIIT VYSVVAIICIPIAGYLSDRFGRKKILLPCLLIAGLGGAVAAFASTYMKNPYAMILAGR VLQGIGSAGAAPIVMPFIGDLFKGDDEKVSAGLGDIETANTSGKVLSPILGALLASWY WFVPFWFIPFFCLISFLLVLFLVAKPEEDEDAPAVSEFIKSVKKIFKQDGRWLYTVFI IGCVIMFLLFGVLFYLSDTLENKYAIDGVAKGGLLAIPLLFLSTSSFIAGKKIGKDKG RMKFCVVTGMILLTLSFIALWWNHSFYFLFVFLSFGGIGIGMALPALDALITEGIESE QCGTISSFYNSMRFIGVALGPPVFAALMSNANWIIFILSAFCSIVSLFLVLFTVDAKK SEEEKNLGTV*" /label="bcbE CDS" gene 1629470..1630678 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /label="bcbE gene" downshifts 1630636 /Source="Nicolas_upshifts" /id="D908" /incds=0 /nref=1 /ntot=32 /MaxReadThrough="1.34389" /MaxDrop="3.00655" /score="5.64651968" /energy="-6.7" /TU="NA" /idTUdmin="U1348" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1630747..1630754 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1630767..1630786 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1630789 /Source="Nicolas_upshifts" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" promotor_-35 1630801..1630804 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1630820..1630832 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1630834 /Source="Nicolas_upshifts" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1630858..1632138 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metalloprotease" /protein_id="NP_389566.2" /db_xref="EnsemblGenomes-Gn:BSU16845" /db_xref="EnsemblGenomes-Tr:CAB13557" /db_xref="GOA:O31764" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="SubtiList:BG13426" /db_xref="UniProtKB/Swiss-Prot:O31764" /translation="MSYVNELKSKHGGLTAHIVKTEKFKTVSLIFKMLAPLTKDQVTK RALLPHVLLRGTKSHPKTAGLRSYLDELYGTSVSADLTKKGERHVITFRLEIPNEKYL KDQTPLLEKGLQLLAELVFSPALEGDAFQSQYVAQEKRTLKQRIQAVYDDKMRYSNLR LIQEMCKNDPYALHVNGEIDDVDDITAEQLYETYQSAIQKDQLDLYVVGDVDSNQVQS AIDKYFKTEERTLGMIENNHADEKVQPKEVIDEEDVKQGKLNIGYRTSITYTDQDYPA LQVFNGLFGGFSHSKLFINVREKASLAYYAASRIESFKGLLMVMSGIEVKNFEQAVSI IAEQFQAMKNGDFSEQDIAQTKAVIRNQVLETIDTAYGLSEFLYQQAAAQVEIPIEDF LANIENVTKEDIIKAGEKIQLDTTYFLKGTEGAS*" /label="ymfF CDS" gene 1630858..1632138 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /label="ymfF gene" CDS 1632135..1633421 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative processing protease" /protein_id="NP_389568.2" /db_xref="EnsemblGenomes-Gn:BSU16860" /db_xref="EnsemblGenomes-Tr:CAB13559" /db_xref="GOA:O31766" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG13428" /db_xref="UniProtKB/Swiss-Prot:O31766" /translation="MIKPIEYEQLQETLYHEKMSNGLDVYVLPKKGFNKTYAVFTTKY GSIDNRFVPLGKNEMVHVPDGIAHFLEHKLFEKADGDVFQDFSKQGASANAFTSFTRT AYLFSSTSNVERNLETLIDFVQDPYFTEKTVEKEKGIIGQEINMYDDNPDWRLYFGVI ENMYKEHPVRIDIAGTVESISHITKDLLYECYETFYHPSNMLLFIVGPVDPEAIISQV RENQGKKPYTDQPEIKREEVKEQEAVFRKEKEIKMNVQGPKCLVGLKSKNPFKLGKEL LKHELSMNLLLEALFGKSSAQYESLYEKGYIDETFSFDFTAEYGFGFAAIGGDTPEPD QLAEDISSMLLRAGELITAEKIELARKKKIGTFLKALNSPEYIANQFTRYAFLDMSLF DVVTVLEQITLEDVQNVIQEEIAADRLTVCKVVPKS*" /label="ymfH CDS" gene 1632135..1633421 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /label="ymfH gene" downshifts 1633271 /Source="Nicolas_upshifts" /id="D909" /incds=1 /nref=10 /ntot=159 /MaxReadThrough="5.673" /MaxDrop="3.16735" /score="1.51160893" /energy="-10.4" /TU="U1349,U1350" /idTUdmin="U1350" /TUdmin="-1256" /isTUend="FALSE" /label="downshifts" S_feature 1633422..1633475 /Source="Nicolas_S_feature" /locus_tag="new_1759601_1759654" /HighExp="Etha, dia15, H2O2, G135, G150, G180, Paraq, LBGexp, Oxctl, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.431, 0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S603" CDS 1633476..1634204 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15066026, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 28787546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="EF-P-5 aminopentanone reductase (EF-P repair enzyme), NADPH-dependent" /protein_id="NP_389569.2" /db_xref="EnsemblGenomes-Gn:BSU16870" /db_xref="EnsemblGenomes-Tr:CAB13560" /db_xref="GOA:O31767" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13429" /db_xref="UniProtKB/Swiss-Prot:O31767" /translation="MNKTALITGASGGIGKSISETLAARGYNLLLHYNTNQNAAAELA EKLSQMFGVNAEILQADLSAQDGADKLTSSIVQPIDAIVLNSGRSHFGLITDVDNATV QEMVQLHVASPYMLTRNLLPGMIRNKSGAIVAVSSIWGETGASCEVLYSMAKGAQHSF VKGLAKELAPSGIRVNAVAPGAVDTNMMNQFTPAEKEEIADEIPIGRLARPQEIADAT AFLLSEKASYITGQILSVNGGWHC*" /label="efpI CDS" gene 1633476..1634204 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /label="efpI gene" promotor_-35 1634220..1634226 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1634238 /Source="Nicolas_upshifts" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1634240..1634251 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1634251) /Source="Nicolas_upshifts" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1634262..1634276) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1634285..1634289) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1634285..1634542 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389570.1" /db_xref="EnsemblGenomes-Gn:BSU16880" /db_xref="EnsemblGenomes-Tr:CAB13561" /db_xref="InterPro:IPR021637" /db_xref="InterPro:IPR024702" /db_xref="SubtiList:BG13430" /db_xref="UniProtKB/Swiss-Prot:O31768" /translation="MSVLENWDSWKNFLGDRLNYAQDKGMSQDTITDLATEIGSYLAN EVESKNEQEKVLADLWSVASKDEQHAIANMMVKLVENNSTH*" /label="ymfJ CDS" gene 1634285..1634542 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /label="ymfJ gene" downshifts 1634527 /Source="Nicolas_upshifts" /id="D910" /incds=0 /nref=165 /ntot=250 /MaxReadThrough="4.58488" /MaxDrop="7.23574" /score="21.9507801" /energy="-8.7" /TU="U1349,U1351" /idTUdmin="U1350" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1634559) /Source="Nicolas_upshifts" /id="D911" /incds=0 /nref=2 /ntot=15 /MaxReadThrough="3.44398" /MaxDrop="3.96475" /score="-6.33040789" /energy="-7.2" /TU="NA" /idTUdmin="U1344" /TUdmin="-11987" /isTUend="FALSE" /label="downshifts" promotor_-35 1634600..1634603 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1634618..1634637 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1634618 /Source="Nicolas_upshifts" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" CDS 1634672..1635187 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; N-terminal part of YmfK" /db_xref="SubtiList:BG13431" /translation="MAKLEWYFEYEIQVNRPGLLGDISSLLGMLSINIVTINGVDLSR RGMLLRCRHIDQIKRLESILKTMETIKVTKLREPRLRDRLAVRHGRYIQRDADDKKTF RFERDELGLLVDFMAELFKKEGHKLIGIRGMPRVGKTESIVASSVCEQKVAVCVINLA EADDKKPADCR*" /label="ymfKn CDS" gene 1634672..1635187 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /pseudo /label="ymfKn gene" CDS 1635123..1635461 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; C-terminal part of YmfK" /db_xref="SubtiList:BG13432" /translation="RWLFVSSTLLKQTIRSQLIADEYSTENVFIVDGIVSTRRGSERH LQLVREIMRLPATKVVEHPDIFVQNTEYTLDDFDYIIELRNDPDEVITYEHAEEPQMF DQSGFSSFDF*" /label="ymfKc CDS" gene 1635123..1635461 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /pseudo /label="ymfKc gene" CDS 1635528..1636394 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 19164570, 22720735, 23879732, 27415800, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 19164570, 22720735, 23879732, 27415800, 27818647; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell shape determination factor" /protein_id="NP_389573.3" /db_xref="EnsemblGenomes-Gn:BSU16910" /db_xref="EnsemblGenomes-Tr:CAB13564" /db_xref="GOA:O31771" /db_xref="InterPro:IPR025194" /db_xref="SubtiList:BG13433" /db_xref="UniProtKB/Swiss-Prot:O31771" /translation="MSLDDLQAATKIQKRYLTALEEGNYDIIPGKFYVRAFIKQYAEA VGLDADQLFEEHKKDIPNTYHDDVSEKISGMNLQKEMPKPASKALELLPTILVILGVI VVIAIVYAIIQFANHKNSDDHNAASEKAITQSESKYEIPKDSTLKENQNNSSEKETDT KKETKENEDKKKENDSEKLEIKAAGTEGSLTTYEVSGADKIELELKASDSSWIRVRDE NSSSLKEGTLKKDETYKKDITDQKQVDIRTGYAPNLKIKINGKVLSYELDPKKVMAQT IKIVNKKEEKSS*" /label="rodZ CDS" gene 1635528..1636394 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /label="rodZ gene" promotor_no_box 1635591..1635691 /Source="Nicolas_upshift_promotors" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_no_box" upshifts 1635651 /Source="Nicolas_upshifts" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" downshifts 1636354 /Source="Nicolas_upshifts" /id="D912" /incds=0 /nref=1 /ntot=107 /MaxReadThrough="5.43253" /MaxDrop="2.8328" /score="21.9507801" /energy="-8.7" /TU="U1353,U1354" /idTUdmin="U1351" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1636444..1637025 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /EC_number="2.7.8.5" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15743965, 15849754, 16514141, 16850406, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15743965, 15849754, 16514141, 16850406, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase" /protein_id="NP_389574.2" /db_xref="EnsemblGenomes-Gn:BSU16920" /db_xref="EnsemblGenomes-Tr:CAB13565" /db_xref="GOA:P46322" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004570" /db_xref="SubtiList:BG11373" /db_xref="UniProtKB/Swiss-Prot:P46322" /translation="MFNLPNKITLARIALIPIFMIIMLAPFDWGRLEVGDESIPVAHL AGAILFIIASTTDWVDGYYARKLNLVTNFGKFLDPLADKLLVSAALIILVQFDLAPAW MVIVIISREFAVTGLRLVLAGTGEVVAANMLGKIKTWAQIIAVSALLLHNLPFELVSF PFADLALWVAVFFTVVSGWEYFSKNWEALKTSN*" /label="pgsA CDS" gene 1636444..1637025 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /label="pgsA gene" CDS 1637043..1638293 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438773, 11703670, 20480359; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence-damage inducible regulator" /protein_id="NP_389575.2" /db_xref="EnsemblGenomes-Gn:BSU16930" /db_xref="EnsemblGenomes-Tr:CAB13566" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008135" /db_xref="InterPro:IPR008136" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036653" /db_xref="SubtiList:BG11374" /db_xref="UniProtKB/Swiss-Prot:P46323" /translation="MEFPKKAEIIAVGSELLLGQIANTNAQFISKQLAEIGVNVFYHT AVGDNPERLKQVIRIAEERSDFIIFSGGLGPTKDDLTKETIANTLGRPLVLNDEAFQS IEDYFKRTKRTMSPNNRKQALVIEGSDVLANHFGMAPGMLTEHESRYYMLLPGPPSEL RPMFENEAKPLLLKKMGSNEKIVSTVLRFFGIGESQLEADLEDIIDAQTNPTIAPLAA DGEVTLRLTAKHADEKETERLLKETEAVILERVGEFFYGYDDTSLVKELSIACKEKGI TISAAESFTGGLFSEWLTDHSGASKLFAGGVVCYTNDVKQNVLGVKKETLDRFGAVSK ECASELAKGVQKLTGSDIGISFTGVAGPDAQEGHEPGHVFIGISANGKEEVHEFHFAG SRTGIRKRGAKYGCHLILKLLEQK*" /label="cinA CDS" gene 1637043..1638293 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /label="cinA gene" S_feature 1638294..1638420 /Source="Nicolas_S_feature" /locus_tag="new_1764473_1764599" /HighExp="LBGstat, LBGtran, G135, Lbstat, G150, C30, LBGexp, dia0, S0, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.016, 0.998" /TUlongSig="SigA" /TUlongPSig="0.987" /label="S604" promotor_-35 1638400..1638407 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1638422..1638441 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1638422 /Source="Nicolas_upshifts" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" CDS 1638466..1639512 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191; Product type f: factor" /codon_start=1 /transl_table=11 /product="multifunctional SOS repair factor" /protein_id="NP_389576.2" /db_xref="EnsemblGenomes-Gn:BSU16940" /db_xref="EnsemblGenomes-Tr:CAB13567" /db_xref="GOA:P16971" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013765" /db_xref="InterPro:IPR020584" /db_xref="InterPro:IPR020587" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR023400" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10721" /db_xref="UniProtKB/Swiss-Prot:P16971" /translation="MSDRQAALDMALKQIEKQFGKGSIMKLGEKTDTRISTVPSGSLA LDTALGIGGYPRGRIIEVYGPESSGKTTVALHAIAEVQQQGGQAAFIDAEHALDPVYA QKLGVNIEELLLSQPDTGEQALEIAEALVRSGAVDIVVVDSVAALVPKAEIEGDMGDS HVGLQARLMSQALRKLSGAINKSKTIAIFINQIREKVGVMFGNPETTPGGRALKFYSS VRLEVRRAEQLKQGNDVMGNKTKIKVVKNKVAPPFRTAEVDIMYGEGISKEGEIIDLG TELDIVQKSGSWYSYEEERLGQGRENAKQFLKENKDIMLMIQEQIREHYGLDNNGVVQ QQAEETQEELEFEE*" /label="recA CDS" gene 1638466..1639512 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /label="recA gene" downshifts 1639524 /Source="Nicolas_upshifts" /id="D913" /incds=0 /nref=201 /ntot=262 /MaxReadThrough="4.54659" /MaxDrop="9.405" /score="23.91264" /energy="-9.7" /TU="U1355" /idTUdmin="U1353" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature 1639569..1639634 /Source="Nicolas_S_feature" /locus_tag="new_1765748_1765813" /HighExp="S7, S5, S8, S4, H2O2, C30, T5.0H, S6, ferm, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="Sig-, SigA, SigA" /TUlongPSig="0.016, 0.998, 0.987" /label="S605" promotor_-35 1639606..1639615 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1639628..1639643 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1639636 /Source="Nicolas_upshifts" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="upshifts" CDS 1639680..1640855 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14762009, 15758244, 21856855" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762009, 15758244, 21856855; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding endopeptidase X (lysozyme resistance)" /protein_id="NP_389577.1" /db_xref="EnsemblGenomes-Gn:BSU16950" /db_xref="EnsemblGenomes-Tr:CAB13568" /db_xref="GOA:O31773" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="SubtiList:BG12642" /db_xref="UniProtKB/Swiss-Prot:O31773" /translation="MTSPTRRRTAKRRRRKLNKRGKLLFGLLAVMVCITIWNALHRNS EENEPSQETAAVSNTDQKKEVKKKTAKKSEEQIKTVDRNQKISNYLKEIGFSGTAMIV RNGEIVTNKGFGYADRKHYIQNNPLTSFYVGSSQKALIATAILQLEEKGKLQTSDPVS TYLPHFPNGQTITLKNLLTHTSGINGHIEGNGAITPDDLIKDIELQGIKRQPGVWDYK DSNYSVLAYIIAEVSGEPYEQYIKNHIFKPAGMTHAGFYKTYEKEPYPAVGYKMEGSK TVTPYIPDLSQLYGAGDIYMSAIDMYKFDQALIDGKLYSQKSYEKMFTPGSSSTYGMG FYVAPGSYSNHGVMPGFNILNSFSKSGQTIVILFSNIQNNAKLGQVNNKIYQLLNQE* " /label="pbpX CDS" gene 1639680..1640855 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /label="pbpX gene" S_feature 1640856..1640955 /Source="Nicolas_S_feature" /locus_tag="new_1767035_1767134" /HighExp="dia0, LBGexp, Lbexp, Oxctl, Paraq, H2O2, C30, G150, Mt0, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.54369999999999996" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA, Sig-, SigA, SigA" /TUlongPSig="1, 0.016, 0.998, 0.987" /label="S606" promotor_-35 1640929..1640936 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1640950..1640969 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" S_feature 1640957..1641130 /Source="Nicolas_S_feature" /locus_tag="new_1767136_1767309" /HighExp="M9-stat, T3.30H, BC, T2.0H, T3.0H, T-1.40H, T1.30H, T2.30H, T4.0H, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S607" upshifts 1640957 /Source="Nicolas_upshifts" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="upshifts" CDS 1641131..1642693 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /EC_number="3.1.26.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease Y" /protein_id="NP_389578.1" /db_xref="EnsemblGenomes-Gn:BSU16960" /db_xref="EnsemblGenomes-Tr:CAB13569" /db_xref="GOA:O31774" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR017705" /db_xref="InterPro:IPR022711" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG13420" /db_xref="UniProtKB/Swiss-Prot:O31774" /translation="MTPIMMVLISILLILLGLVVGYFVRKTIAEAKIAGARGAAEQIL EDAKRDAEALKKEALLEAKDEIHKLRIDAEQEVRERRNELQKQENRLLQKEENLDRKH EGIDKREAMLEKKDHSLNERQQHIEEMESKVDEMIRMQQSELERISSLTRDEAKQIIL ERVENELSHDIAIMTKETENRAKEEADKKAKNILSLALQRCAADHVAETTVSVVNLPN DEMKGRIIGREGRNIRTLETLTGIDLIIDDTPEAVILSGFDPIRRETARIALDKLVQD GRIHPARIEEMVEKSRREVDDYIREMGEQTTFEVGVHGLHPDLIKILGRLKFRTSYGQ NVLKHSMEVAFLAGLMASELGEDAKLAKRAGLLHDIGKAIDHEVEGSHVEIGVELATK YKEHPVVINSIASHHGDEEPTSIIAVLVAAADALSAARPGARSETLENYIRRLEKLEE ISESYEGVEKSFAIQAGREVRIMVKPDSINDLEAHRLARDIRKRIEDELDYPGHIKVT VIRETRAVEYAK*" /label="rny CDS" gene 1641131..1642693 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /label="rny gene" downshifts 1642670 /Source="Nicolas_upshifts" /id="D914" /incds=0 /nref=243 /ntot=268 /MaxReadThrough="5.32126" /MaxDrop="5.3789" /score="10.4712371" /energy="-9" /TU="U1357" /idTUdmin="U1357" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" CDS 1642762..1643556 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19376879, 21856853, 24163345, 26904951, 26906740" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19376879, 21856853, 24163345, 26904951, 26906740; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2'3' and 3'5' cyclic nucleotide monophosphates phosphodiesterase involved in biofilm formation" /protein_id="NP_389579.2" /db_xref="EnsemblGenomes-Gn:BSU16970" /db_xref="EnsemblGenomes-Tr:CAB13570" /db_xref="GOA:O31775" /db_xref="InterPro:IPR005235" /db_xref="InterPro:IPR029052" /db_xref="PDB:4B2O" /db_xref="SubtiList:BG13421" /db_xref="UniProtKB/Swiss-Prot:O31775" /translation="MRILFIGDVVGSPGRDMVKEYVPKLKTKYKPHFTIINGENAAHG KGLTEKIYHSLIQSGADAITMGNHTWDKKEIFDFIDDVPNLVRPANFPEGTPGKGITY VKANGKELAVINLQGRTFLPPLDDPFLKADELIAEAAKRTPYIFIDFHAEATSEKLAL GWYTDGRASAVVGTHTHVQTADNRILPKGTAYITDVGMTGPYDGILGMDRETIIKRFK TNLPVRFTVAEGKTTLSGVVIDIDDQTKKAVKIERILINDDHMFFE*" /label="pdeB CDS" gene 1642762..1643556 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /label="pdeB gene" promotor_-35 1643311..1643316 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1643332..1643350 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1643352 /Source="Nicolas_upshifts" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="upshifts" promotor_-35 1643600..1643605 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-35" S_feature 1643616..1643755 /Source="Nicolas_S_feature" /locus_tag="new_1769795_1769934" /HighExp="T5.0H, LoTm, BT, B60, S8, M9-stat, S6, BC, B36, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="0.916, 0.91, 1" /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S608" upshifts 1643616 /Source="Nicolas_upshifts" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="upshifts" promotor_-10 1643621..1643639 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-10" upshifts complement(1643648) /Source="Nicolas_upshifts" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1643659..1643672) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1643681..1643685) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1643692) /Source="Nicolas_upshifts" /id="D915" /incds=0 /nref=5 /ntot=35 /MaxReadThrough="1.51152" /MaxDrop="3.63977" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=10274 /isTUend="FALSE" /label="downshifts" CDS 1643756..1644016 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /function="16.3: Control" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7559352, 16428420, 18562273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559352, 16428420, 18562273; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for dehydratation of the spore core and assembly of the coat (stage V sporulation)" /protein_id="NP_389580.1" /db_xref="EnsemblGenomes-Gn:BSU16980" /db_xref="EnsemblGenomes-Tr:CAB13571" /db_xref="GOA:P45693" /db_xref="InterPro:IPR007347" /db_xref="SubtiList:BG11245" /db_xref="UniProtKB/Swiss-Prot:P45693" /translation="MEILKVSAKSSPNSVAGALAGVLRERGAAEIQAIGAGALNQAVK AVAIARGFVAPSGVDLICIPAFTDIQIDGEERTAIKLIVEPR*" /label="spoVS CDS" gene 1643756..1644016 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /label="spoVS gene" downshifts 1643968 /Source="Nicolas_upshifts" /id="D916" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="8.31914" /MaxDrop="4.27515" /score="5.18548432" /energy="-12.5" /TU="U1357,U1358,U1359" /idTUdmin="U1357" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts complement(1644000) /Source="Nicolas_upshifts" /id="D917" /incds=0 /nref=3 /ntot=15 /MaxReadThrough="1.16149" /MaxDrop="3.88837" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=9966 /isTUend="FALSE" /label="downshifts" downshifts 1644012 /Source="Nicolas_upshifts" /id="D918" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.08266" /MaxDrop="5.124" /score="5.18548432" /energy="-12.5" /TU="U1358,U1359" /idTUdmin="U1357" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1644057..1644231 /Source="Nicolas_S_feature" /locus_tag="new_1770236_1770410" /HighExp="S6, S8, S7, M9-stat, Lbstat, BT, S5, T1.30H, T2.0H, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.916, 0.91" /TUlongSig="SigA, SigWXY" /TUlongPSig="1, 1" /label="S609" promotor_-35 1644215..1644222 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1644233 /Source="Nicolas_upshifts" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1644237..1644256 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1644282..1645325 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /EC_number="1.1.1.103" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8519804, 16817900, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine 3-dehydrogenase" /protein_id="NP_389581.1" /db_xref="EnsemblGenomes-Gn:BSU16990" /db_xref="EnsemblGenomes-Tr:CAB13572" /db_xref="GOA:O31776" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR004627" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12685" /db_xref="UniProtKB/Swiss-Prot:O31776" /translation="MQSGKMKALMKKDGAFGAVLTEVPIPEIDKHEVLIKVKAASICG TDVHIYNWDQWARQRIKTPYVFGHEFSGIVEGVGENVSSVKVGEYVSAETHIVCGECV PCLTGKSHVCTNTAIIGVDTAGCFAEYVKVPADNIWRNPADMDPSIASIQEPLGNAVH TVLESQPAGGTTAVIGCGPIGLMAVAVAKAAGASQVIAIDKNEYRLRLAKQMGATCTV SIEKEDPLKIVSALTSGEGADLVCEMSGHPSAIAQGLAMAANGGRFHILSLPEHPVTI DLTNKVVFKGLTIQGITGRKMFSTWRQVSQLISSNMIDLAPVITHQFPLEEFEKGFEL MRSGQCGKVILIP*" /label="tdh CDS" gene 1644282..1645325 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /label="tdh gene" CDS 1645338..1646516 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /EC_number="2.3.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17146529, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-amino-3-ketobutyrate CoA ligase (glycine acetyl transferase)" /protein_id="NP_389582.1" /db_xref="EnsemblGenomes-Gn:BSU17000" /db_xref="EnsemblGenomes-Tr:CAB13573" /db_xref="GOA:O31777" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR010962" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12610" /db_xref="UniProtKB/Swiss-Prot:O31777" /translation="MTKEFEFLKAELNSMKENHTWQDIKQLESMQGPSVTVNHQKVIQ LSSNNYLGFTSHPRLINAAQEAVQQYGAGTGSVRTIAGTFTMHQELEKKLAAFKKTEA ALVFQSGFTTNQGVLSSILSKEDIVISDELNHASIIDGIRLTKADKKVYQHVNMSDLE RVLRKSMNYRMRLIVTDGVFSMDGNIAPLPDIVELAEKYDAFVMVDDAHASGVLGENG RGTVNHFGLDGRVHIQVGTLSKAIGVLGGYAAGSKVLIDYLRHKGRPFLFSTSHPPAV TAACMEAIDVLLEEPEHMERLWENTAYFKAMLVKMGLTLTKSETPILPILIGDEGVAK QFSDQLLSRGVFAQSIVFPTVAKGKARIRTIITAEHTKDELDQALDVIEKTAKELQLL *" /label="kbl CDS" gene 1645338..1646516 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /label="kbl gene" downshifts 1646498 /Source="Nicolas_upshifts" /id="D919" /incds=0 /nref=3 /ntot=25 /MaxReadThrough="5.75732" /MaxDrop="3.4918" /score="4.73069387" /energy="-12.5" /TU="U1361" /idTUdmin="U1359" /TUdmin=1936 /isTUend="FALSE" /label="downshifts" promotor_-35 1646596..1646599 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1646608 /Source="Nicolas_upshifts" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1646614..1646633 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1646664..1648193 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /EC_number="2.8.4.3" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15175311, 18307109, 20472640, 20584901, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 18307109, 20472640, 20584901, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme for ms(2)i(6)A formation for tRNA modification" /protein_id="NP_389583.1" /db_xref="EnsemblGenomes-Gn:BSU17010" /db_xref="EnsemblGenomes-Tr:CAB13574" /db_xref="GOA:O31778" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006463" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="SubtiList:BG13418" /db_xref="UniProtKB/Swiss-Prot:O31778" /translation="MNEKQKLESGQVHPSDKKSEKDYSKYFEAVYIPPSLKDAKKRGK EAVTYHNDFKISEQFKGLGDGRKFYIRTYGCQMNEHDTEVMAGIFMALGYEATNSVDD ANVILLNTCAIRENAENKVFGELGHLKALKKNNPDLILGVCGCMSQEESVVNRILKKH PFVDMIFGTHNIHRLPELLSEAYLSKEMVVEVWSKEGDVIENLPKVRNGKIKGWVNIM YGCDKFCTYCIVPYTRGKERSRRPEDIIQEVRRLASEGYKEITLLGQNVNAYGKDFED MTYGLGDLMDELRKIDIPRIRFTTSHPRDFDDRLIEVLAKGGNLLDHIHLPVQSGSSE VLKLMARKYDRERYMELVRKIKEAMPNASLTTDIIVGFPNETDEQFEETLSLYREVEF DSAYTFIYSPREGTPAAKMKDNVPMRVKKERLQRLNALVNEISAKKMKEYEGKVVEVL VEGESKNNPDILAGYTEKSKLVNFKGPKEAIGKIVRVKIQQAKTWSLDGEMVGEAIEV K*" /label="miaB CDS" gene 1646664..1648193 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /label="miaB gene" CDS 1648195..1648626 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator for biofilm formation via regulation of RNase Y (RicAFT complex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389584.1" /db_xref="EnsemblGenomes-Gn:BSU17020" /db_xref="EnsemblGenomes-Tr:CAB13575" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR016783" /db_xref="InterPro:IPR023378" /db_xref="PDB:2PIH" /db_xref="SubtiList:BG13417" /db_xref="UniProtKB/Swiss-Prot:O31779" /translation="MTLYSKKDIVQQARNLAKMISETEEVDFFKRAEAQINENDKVST IVNQIKALQKQAVNLKHYEKHEALKQVEAKIDALQEELEEIPVIQEFRDSQMEVNDLL QLVAHTISNQVTNEIITSTGGDLLKGETGSKVKHSNNSCSL*" /label="ricA CDS" gene 1648195..1648626 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /label="ricA gene" downshifts 1648609 /Source="Nicolas_upshifts" /id="D920" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="0.9572" /MaxDrop="7.73043" /score="21.1260722" /energy="-10.3" /TU="NA" /idTUdmin="U1361" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1648757..1648762 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1648778..1648796 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1648786..1648887 /Source="Nicolas_S_feature" /locus_tag="new_1774965_1775066" /HighExp="S3, S5, S8, S4, S6, S7, B36, BT, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S610" upshifts 1648786 /Source="Nicolas_upshifts" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="upshifts" CDS 1648888..1649433 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenic spore protein" /protein_id="NP_389585.1" /db_xref="EnsemblGenomes-Gn:BSU17030" /db_xref="EnsemblGenomes-Tr:CAB13576" /db_xref="GOA:P14016" /db_xref="InterPro:IPR018901" /db_xref="SubtiList:BG10494" /db_xref="UniProtKB/Swiss-Prot:P14016" /translation="MSEYREIITKAVVAKGRKFTQCTNTISPEKKPSSILGGWIINHK YDAEKIGKTVEIEGYYDINVWYSYADNTKTEVVTERVKYVDVIKLRYRDNNYLDDEHE VIAKVLQQPNCLEVTISPNGNKIVVQAEREFLAEVVGETKVVVEVNPDWEEDDEEDWE DELDEELEDINPEFLVGDPEE*" /label="cotE CDS" gene 1648888..1649433 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /label="cotE gene" downshifts 1649427 /Source="Nicolas_upshifts" /id="D921" /incds=0 /nref=64 /ntot=97 /MaxReadThrough="4.37388" /MaxDrop="8.23792" /score="10.7927556" /energy="-12.6" /TU="U1363" /idTUdmin="U1363" /TUdmin="-745" /isTUend="FALSE" /label="downshifts" downshifts complement(1649434) /Source="Nicolas_upshifts" /id="D922" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="4.21458" /MaxDrop="3.44208" /score="12.3953461" /energy="-11.4" /TU="NA" /idTUdmin="U1366" /TUdmin=4532 /isTUend="FALSE" /label="downshifts" promotor_-35 1649491..1649494 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1649509..1649528 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1649513 /Source="Nicolas_upshifts" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="upshifts" CDS 1649566..1652142 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /function="16.5: Explore" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15375129, 16269814, 23998896, 26343983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 16269814, 23998896, 26343983; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA mismatch repair recognition factor" /protein_id="NP_389586.2" /db_xref="EnsemblGenomes-Gn:BSU17040" /db_xref="EnsemblGenomes-Tr:CAB13577" /db_xref="GOA:P49849" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR005748" /db_xref="InterPro:IPR007695" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR007860" /db_xref="InterPro:IPR007861" /db_xref="InterPro:IPR016151" /db_xref="InterPro:IPR017261" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036187" /db_xref="InterPro:IPR036678" /db_xref="SubtiList:BG11403" /db_xref="UniProtKB/Swiss-Prot:P49849" /translation="MAGYTPMIQQYLKIKAEHQDAFLFFRLGDFYEMFFEDAKKASQE LEITLTSRDGGAAEKIPMCGVPYHSASAYIEQLIKKGYKVAICEQTEDPKAAKGVVKR EVVQLITPGTVMDGKGIHESENNFIASVSACSNGYGLALSDLTTGENLAVLIERLEDV ISEIYSVGAREIVVSGSLDADTVAQLRERCGATISIEDGETDEHVTIIEHLNNEDITK TFLRLYTYLKRTQKRSLDHLQPVQVYELEEAMKIDLYSKRNLELTETIRSKNKKGSLL WLLDETKTAMGGRLLKQWIDRPLIRVNQIEERQEMVETLMSHFFEREDLRERLKEVYD LERLAGRVAFGNVNARDLIQLKESLKQVPGIKQLVASLAHDKAKERAKRIDPCGDVLE LLEEALYENPPLSVKEGNLIKDGYNQKLDEYRDASRNGKDWIARLEQQEREYTGIRSL KVGFNKVFGYYIEVTKANLHLLEEGRYERKQTLTNAERYITPELKEKEALILEAENNI CELEYELFTELREKVKQYIPRLQQLAKQMSELDALQCFATISENRHYTKPEFSKDEVE VIEGRHPVVEKVMDSQEYVPNNCMMGDNRQMLLITGPNMSGKSTYMRQIALISIMAQI GCFVPAKKAVLPIFDQIFTRIGAADDLISGQSTFMVEMLEAKNAIVNATKNSLILFDE IGRGTSTYDGMALAQAIIEYVHDHIGAKTLFSTHYHELTVLEDKLPQLKNVHVRAEEY NGTVVFLHQIKEGAADKSYGIHVAQLAELPGDLIARAQDILKELEHSGNKPEVPVQKP QVKEEPAQLSFFDEAEKPAETPKLSKKEKQVIDAFKSLNILDMTPLEAMNEMYKLQKK LH*" /label="mutS CDS" gene 1649566..1652142 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /label="mutS gene" CDS 1652158..1654041 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15375129, 22843852, 26343983, 26384423, 27369079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 22843852, 26343983, 26384423, 27369079; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA mismatch repair endonuclease" /protein_id="NP_389587.1" /db_xref="EnsemblGenomes-Gn:BSU17050" /db_xref="EnsemblGenomes-Tr:CAB13578" /db_xref="GOA:P49850" /db_xref="InterPro:IPR002099" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR013507" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR014762" /db_xref="InterPro:IPR014790" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020667" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037198" /db_xref="PDB:3GAB" /db_xref="PDB:3KDG" /db_xref="PDB:3KDK" /db_xref="SubtiList:BG11402" /db_xref="UniProtKB/Swiss-Prot:P49850" /translation="MAKVIQLSDELSNKIAAGEVVERPASVVKELVENAIDADSTVIE IDIEEAGLASIRVLDNGEGMENEDCKRAFRRHATSKIKDENDLFRVRTLGFRGEALPS IASVSHLEITTSTGEGAGTKLVLQGGNIISESRSSSRKGTEIVVSNLFFNTPARLKYM KTVHTELGNITDVVNRIALAHPEVSIRLRHHGKNLLQTNGNGDVRHVLAAIYGTAVAK KMLPLHVSSLDFEVKGYIALPEITRASRNYMSSVVNGRYIKNFPLVKAVHEGYHTLLP IGRHPITFIEITMDPILVDVNVHPSKLEVRLSKETELHDLIRDGIKDVFKQQQLIPSA QVPKKSAPAIKNEQQFITFDEKPPEKKVPEKSTAPSYSPMKLSSVVKEPVDAEEKLPP LQFDAPPIVDQEQTLEVSDVSAEQPETFEQECHEEQPQPASDRVPIMYPIGQMHGTYI LAQNENGLYIIDQHAAQERIKYEYFREKVGEVEPEVQEMIVPLTFHYSTNEALIIEQH KQELESVGVFLESFGSNSYIVRCHPAWFPKGEEAELIEEIIQQVLDSKNIDIKKLREE AAIMMSCKGSIKANRHLRNDEIKALLDDLRSTSDPFTCPHGRPIIIHHSTYEMEKMFK RVM*" /label="mutL CDS" gene 1652158..1654041 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /label="mutL gene" S_feature complement(1653944..1654438) /Source="Nicolas_S_feature" /locus_tag="new_1780123_1780617_c" /HighExp="M9-stat, LBGstat, LPhT, T2.0H, Lbstat, C30, T2.30H, M0t90, T1.30H, HiOs" /AntisenseName="mutL" /AntisenseCor="0.27126904061692803" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S611" downshifts 1653956 /Source="Nicolas_upshifts" /id="D923" /incds=1 /nref=216 /ntot=257 /MaxReadThrough="2.0064" /MaxDrop="5.37369" /score="33.4967163" /energy="-18.6" /TU="NA" /idTUdmin="U1364" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1653966) /Source="Nicolas_upshifts" /id="D924" /incds=1 /nref=3 /ntot=100 /MaxReadThrough="1.93338" /MaxDrop="2.7192" /score="27.1353816" /energy="-13.5" /TU="NA" /idTUdmin="U1366" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1654188..1654195 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1654210..1654229 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1654220..1654353 /Source="Nicolas_S_feature" /locus_tag="new_1780399_1780532" /HighExp="LoTm, T0.30H, T1.30H, M9-stat, T3.0H, BC, T1.0H, B60, B36, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99494800000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S612" upshifts 1654220 /Source="Nicolas_upshifts" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(1654225..1654375) /gene="surX" /locus_tag="BSU_misc_RNA_89" /product="small untranslated RNA of unknown function" /note="Evidence 5: Unknown function; PubMedId : 20525796, 23155385" /label="surX RNA" gene complement(1654225..1654375) /gene="surX" /locus_tag="BSU_misc_RNA_89" /label="surX gene" downshifts 1654310 /Source="Nicolas_upshifts" /id="D925" /incds=0 /nref=19 /ntot=136 /MaxReadThrough="3.45962" /MaxDrop="4.12444" /score="29.4045648" /energy="-15.3" /TU="U1365" /idTUdmin="U1364" /TUdmin=354 /isTUend="FALSE" /label="downshifts" CDS complement(1654439..1654894) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="YP_054578.1" /db_xref="EnsemblGenomes-Gn:BSU17060" /db_xref="EnsemblGenomes-Tr:CAE01453" /db_xref="GOA:Q7WY71" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14188" /db_xref="UniProtKB/Swiss-Prot:Q7WY71" /translation="MNQKEQNEHSKDFNLRSKLIGIVSITFIAAIALAVIFGGFFFGM KGLFSILGITYASNQTLALFILACFAVGLIIDPLTKIISIILAKSLSLKKTALFAFIL YFISNLITICFADYFMQSIYIPDVLLVVISAFMAIIELAFDNQPNREAA*" /label="ymzD CDS" gene complement(1654439..1654894) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" /label="ymzD gene" S_feature complement(1654895..1654986) /Source="Nicolas_S_feature" /locus_tag="new_1781074_1781165_c" /HighExp="LBGstat, M9-stat, T1.0H, T1.30H, T2.0H, M0t90, MG 150, LPhT, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S613" promotor_-10 complement(1654974..1654993) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1654986) /Source="Nicolas_upshifts" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1655010..1655013) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1655049..1655606) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389588.1" /db_xref="EnsemblGenomes-Gn:BSU17070" /db_xref="EnsemblGenomes-Tr:CAB13579" /db_xref="GOA:O31780" /db_xref="SubtiList:BG13419" /db_xref="UniProtKB/Swiss-Prot:O31780" /translation="MNGIAWMIVFCEIAFWVVIVLGLAVRYVFKRHTLGLLFLALTPV IDLILLAATGVDLYRGASATAAHGIAAVYIGISIAYGKQMIQWADEKFQYYVTKKGTK PLKRFGMDHAKHGAKGWLRHVLAYLIGAGLLAGMIYFINDSSRTEALSGILKLWTVII GIDFLITASYFIWPKKEKASANLRS*" /label="ymcC CDS" gene complement(1655049..1655606) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" /label="ymcC gene" SCAR 1655697..1655698 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs08" downshifts complement(1655749) /Source="Nicolas_upshifts" /id="D929" /incds=0 /nref=24 /ntot=184 /MaxReadThrough="3.69744" /MaxDrop="5.18486" /score="-0.71313204" /energy="-20.1" /TU="U1374" /idTUdmin="U1375" /TUdmin=28 /isTUend="FALSE" /label="downshifts" CDS complement(1655755..1656111) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11544224, 15805528, 20817675" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function involved in ethanol resistance" /protein_id="NP_389606.3" /db_xref="EnsemblGenomes-Gn:BSU17240" /db_xref="EnsemblGenomes-Tr:CAB13608" /db_xref="SubtiList:BG13435" /db_xref="UniProtKB/Swiss-Prot:O31786" /translation="MAHTNTQLSQWLESKVGQTLDIRKGELTHDEEISDLDQIVLHLQ KVAIRSTNHPDDYVAKEELVLEGEGTTFTEDGNVPLPQNAYEIPLLGELHIHQENEGL KVVTDRAVYTIDIQHS*" /label="ymzB CDS" gene complement(1655755..1656111) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" /label="ymzB gene" misc_feature complement(1656171..1656184) /Source="Nicolas_upshift_promotors" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1656176) /Source="Nicolas_upshifts" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1656190..1657014) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20817675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389607.2" /db_xref="EnsemblGenomes-Gn:BSU17250" /db_xref="EnsemblGenomes-Tr:CAB13609" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13413" /db_xref="UniProtKB/Swiss-Prot:O31787" /translation="MPYYICNTCGVQHAQTVDPPNSCLICEDERQYIHPDGQTWTTLE DMREKGNLQNILKKEEEHLYSIKTEPEFAIGQTAHLIQHKGFNVLWDCMTYLDQKTID QINELGGIQAIALSHPHYYSTQVEWAEAFQAPIYIHEDDKEWVTRPSNHIHFWSGETL NMKPGLDLYRLGGHFKGGAVLHWSKGNEGKGCLLTGDIITVAADRNWVSFMYSYPNLI PLPASKVEEIAAKVKPLQFNRLYNAFSKVVKENADESVQRSAVRYIKALNSELFHT*" /label="ymaE CDS" gene complement(1656190..1657014) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" /label="ymaE gene" promotor_-10 complement(1657036..1657055) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1657052) /Source="Nicolas_upshifts" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1657067..1657073) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1657125..1658453) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10589719, 16267290, 17884659, 28693413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10589719, 16267290, 17884659, 28693413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline serine protease" /protein_id="NP_389608.1" /db_xref="EnsemblGenomes-Gn:BSU17260" /db_xref="EnsemblGenomes-Tr:CAB13610" /db_xref="GOA:O31788" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG12567" /db_xref="UniProtKB/Swiss-Prot:O31788" /translation="MFGYSMVQMVRANAHKLDWPLRETVLQLYKPFKWTPCFLHKFFE TKLQNRKKMSVIIEFEEGCHETGFQMAGEVLQKEKRSKLKSRFNKINCCSAEVTPSAL HSLLSECSNIRKVYLNREVKALLDTATEASHAKEVVRNGQTLTGKGVTVAVVDTGIYP HPDLEGRIIGFADMVNQKTEPYDDNGHGTHCAGDVASSGASSSGQYRGPAPEANLIGV KVLNKQGSGTLADIIEGVEWCIQYNEDNPDEPIDIMSMSLGGDALRYDHEQEDPLVRA VEEAWSAGIVVCVAAGNSGPDSQTIASPGVSEKVITVGALDDNNTASSDDDTVASFSS RGPTVYGKEKPDILAPGVNIISLRSPNSYIDKLQKSSRVGSQYFTMSGTSMATPICAG IAALILQQNPDLTPDEVKELLKNGTDKWKDEDPNIYGAGAVNAENSVPGQ*" /label="aprX CDS" gene complement(1657125..1658453) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" /label="aprX gene" downshifts complement(1657132) /Source="Nicolas_upshifts" /id="D930" /incds=0 /nref=13 /ntot=21 /MaxReadThrough="2.43809" /MaxDrop="5.8915" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1376" /TUdmin=8 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1658476..1658495) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1658495) /Source="Nicolas_upshifts" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1658509..1658517) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1658610..1658617 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1658625..1658644) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1658633..1658652 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1658636) /Source="Nicolas_upshifts" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="upshifts" upshifts 1658639 /Source="Nicolas_upshifts" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1658657..1658664) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1658678..1658755 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of YmzE" /translation="MNFYLHRSLESQMPISIIYEERRND*" /label="ymzEn CDS" gene 1658678..1658755 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /pseudo /label="ymzEn gene" downshifts complement(1658680) /Source="Nicolas_upshifts" /id="D931" /incds=0 /nref=4 /ntot=7 /MaxReadThrough="1.51659" /MaxDrop="5.37668" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1377" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS 1658733..1658909 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of YmzE" /db_xref="PSEUDO:CAX52622.1" /translation="MKKDGTISKRTIIVRQKSKTKIKAFCFSKQQIRTFLLDSILSCD FVRTNKQNLYSAGR*" /label="ymzEc CDS" gene 1658733..1658909 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /pseudo /label="ymzEc gene" downshifts 1658890 /Source="Nicolas_upshifts" /id="D932" /incds=0 /nref=42 /ntot=207 /MaxReadThrough="4.03151" /MaxDrop="6.55778" /score="-0.929304655" /energy="-5.5" /TU="U1378" /idTUdmin="U1378" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" S_feature 1658935..1659123 /Source="Nicolas_S_feature" /locus_tag="new_1863194_1863382" /HighExp="H2O2, M40t90, C90, M40t45, C30, S8, HiOs, G135, T-4.40H, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S619" misc_feature 1659118..1659137 /Source="Nicolas_upshift_promotors" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1659125 /Source="Nicolas_upshifts" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1659189..1659896 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" /EC_number="3.4.19.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16267290, 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="gamma-polyglutamate hydrolase (phage origin)" /protein_id="NP_389609.1" /db_xref="EnsemblGenomes-Gn:BSU17270" /db_xref="EnsemblGenomes-Tr:CAB13611" /db_xref="GOA:O31789" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13411" /db_xref="UniProtKB/Swiss-Prot:O31789" /translation="MRRFLLNVILVLAIVLFLRYVHYSLEPEPSNQPDTYSNFSSLAE NESPADYDISYNEKKGSKVLIMSPHGGRIEGGVSELVRYFNNEYSTYLFEGLKSHDNQ TLHITSTNFDEPLAKKKIKEHQYVVAFHGYKGENKNTLVGGTDRKRAKMIVRALERRG FSAELASSKSGLAGLNAENINNQGETGLSIQLEISREQREAFFDDFYYKNRKYTKNSE FYAYVSAIKGVLEKEYS*" /label="pghC CDS" gene 1659189..1659896 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" /label="pghC gene" promotor_-35 1659907..1659913 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1659927..1659946 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1659931 /Source="Nicolas_upshifts" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1659966..1660418 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290, 22904090, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peroxiredoxin-related protein" /protein_id="NP_389610.1" /db_xref="EnsemblGenomes-Gn:BSU17280" /db_xref="EnsemblGenomes-Tr:CAB13612" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019905" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13412" /db_xref="UniProtKB/Swiss-Prot:O31790" /translation="MADHHFYLKANWPGNRNDVGTIESGNLITSISIPKEMDGPGEGT NPDEMLLGAAATCYIITLAAMMERSGLEKEDLQMESEGIVNVTKGVFTYKKIIHRPSV VLKHDASQDDVALAHKLCKKAESSCMISRAIQGNVELQLEASVKLGGE*" /label="ymaD CDS" gene 1659966..1660418 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" /label="ymaD gene" downshifts 1660406 /Source="Nicolas_upshifts" /id="D933" /incds=0 /nref=44 /ntot=182 /MaxReadThrough="1.35366" /MaxDrop="6.07534" /score="17.0193804" /energy="-12.1" /TU="NA" /idTUdmin="U1379" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1660432..1660785) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 15849754, 16750162, 16850406, 18024586, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 15849754, 16750162, 16850406, 18024586, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389611.1" /db_xref="EnsemblGenomes-Gn:BSU17290" /db_xref="EnsemblGenomes-Tr:CAB13613" /db_xref="GOA:P0CW82" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12586" /db_xref="UniProtKB/Swiss-Prot:P0CW82" /translation="MRGLLYLALAIVSEVFGSTMLKLSEGFTQAWPIAGVIVGFLSAF TFLSFSLKTIDLSSAYATWSGVGTALTAIVGFLLFGETISLKGVFGLTLVIAGVVVLN QSKAHAEDKKQTACE*" /label="ebrB CDS" gene complement(1660432..1660785) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" /label="ebrB gene" downshifts complement(1660473) /Source="Nicolas_upshifts" /id="D934" /incds=0 /nref=2 /ntot=45 /MaxReadThrough="0.84905" /MaxDrop="2.87924" /score="-2.89884673" /energy="-8.7" /TU="NA" /idTUdmin="U1381" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1660799..1661116) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 11104814, 17516673, 18024586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 11104814, 17516673, 18024586; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389612.1" /db_xref="EnsemblGenomes-Gn:BSU17300" /db_xref="EnsemblGenomes-Tr:CAB13614" /db_xref="GOA:P0CW80" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12585" /db_xref="UniProtKB/Swiss-Prot:P0CW80" /translation="MLIGYIFLTIAICSESIGAAMLKVSDGFKKWKPSALVVIGYSLA FYMLSLTLNHIPLSLSYATWSGAGTVLTTVIGVKWFKEDLNAKGLIGILLLLSGVVLL NWP*" /label="ebrA CDS" gene complement(1660799..1661116) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" /label="ebrA gene" promotor_-10 complement(1661160..1661179) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1661168) /Source="Nicolas_upshifts" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1661194..1661201) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1661253..1661528) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19775244, 19933362, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19775244, 19933362, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein; cell wall associated protein" /protein_id="NP_389613.2" /db_xref="EnsemblGenomes-Gn:BSU17310" /db_xref="EnsemblGenomes-Tr:CAB13615" /db_xref="GOA:O31793" /db_xref="SubtiList:BG13415" /db_xref="UniProtKB/Swiss-Prot:O31793" /translation="MNELEHFSPEDTRIFGRPFGFGRPFGFGRPFGFGYGFGRPGFGY GFGRPFGFFGGPFIGGLAGGLIGSALFNPYLYGGYPYYPYAPFPFYY*" /label="ymaG CDS" gene complement(1661253..1661528) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" /label="ymaG gene" downshifts complement(1661254) /Source="Nicolas_upshifts" /id="D935" /incds=0 /nref=38 /ntot=44 /MaxReadThrough="0.28059" /MaxDrop="8.33353" /score="12.3408391" /energy="-11.5" /TU="NA" /idTUdmin="U1383" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1661524..1661529 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-35" promotor_-10 1661545..1661563 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-10" promotor_-10 complement(1661555..1661574) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1661565 /Source="Nicolas_upshifts" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="upshifts" upshifts complement(1661568) /Source="Nicolas_upshifts" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1661587..1661596) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1661617..1662030 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24098137, 25915524" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein of unknown function" /protein_id="NP_389614.2" /db_xref="EnsemblGenomes-Gn:BSU17320" /db_xref="EnsemblGenomes-Tr:CAB13616" /db_xref="InterPro:IPR024307" /db_xref="SubtiList:BG13414" /db_xref="UniProtKB/Swiss-Prot:O31794" /translation="MNTLGLYQSDWSKAPPHAHAYHVKTTREQGHYHLIEGFTQPANG SNTDQHTHYYTGITSFENGHFHRYYGISGPAIPLADGTHYHEIEETTYLAYNEPIEIQ YGGVVYDPGDDRRKTHRHTLKGKTREIVGNEPLGW*" /label="ymaF CDS" gene 1661617..1662030 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /label="ymaF gene" upshifts 1662081 /Source="Nicolas_upshifts" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="upshifts" misc_feature 1662087..1662106 /Source="Nicolas_upshift_promotors" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1662130..1663074 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /EC_number="2.5.1.75" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3045085, 11160115, 26735940, 28277934, 28471404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA isopentenylpyrophosphate transferase" /protein_id="NP_389615.2" /db_xref="EnsemblGenomes-Gn:BSU17330" /db_xref="EnsemblGenomes-Tr:CAB13617" /db_xref="GOA:O31795" /db_xref="InterPro:IPR018022" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12617" /db_xref="UniProtKB/Swiss-Prot:O31795" /translation="MNNTKQPVVILVGPTAVGKTNLSIQLAKSLNAEIISGDSMQIYK GMDIGTAKITEQEMEGVPHHLIDILDPQDSFSTADYQSLVRNKISEIANRGKLPMIVG GTGLYIQSVLYDYTFTEEANDPVFRESMQMAAEREGADFLHAKLAAADPEAAAAIHPN NTRRVIRALEILHTSGKTMSQHLKEQKRELLYNAVLIGLTMDRDTLYERINQRVDLMM QSGLLPEVKRLYDKNVRDCQSIQAIGYKELYAYFDGFVTLSDAVEQLKQNSRRYAKRQ LTWFRNKMQVTWFDMTPPVDMELKKKEIFTHIAGKLEL*" /label="miaA CDS" gene 1662130..1663074 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /label="miaA gene" promotor_-35 1663054..1663062 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-35" promotor_-10 1663073..1663091 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-10" upshifts 1663075 /Source="Nicolas_upshifts" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="upshifts" CDS 1663114..1663335 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927; Product type f: factor" /codon_start=1 /transl_table=11 /product="Hfq RNA chaperone" /protein_id="NP_389616.1" /db_xref="EnsemblGenomes-Gn:BSU17340" /db_xref="EnsemblGenomes-Tr:CAB13618" /db_xref="GOA:O31796" /db_xref="InterPro:IPR005001" /db_xref="InterPro:IPR010920" /db_xref="PDB:3AHU" /db_xref="PDB:3HSB" /db_xref="SubtiList:BG13416" /db_xref="UniProtKB/Swiss-Prot:O31796" /translation="MKPINIQDQFLNQIRKENTYVTVFLLNGFQLRGQVKGFDNFTVL LESEGKQQLIYKHAISTFAPQKNVQLELE*" /label="hfq CDS" gene 1663114..1663335 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /label="hfq gene" downshifts complement(1663125) /Source="Nicolas_upshifts" /id="D936" /incds=0 /nref=3 /ntot=108 /MaxReadThrough="1.19472" /MaxDrop="3.56162" /score="-5.83707008" /energy="-5.2" /TU="NA" /idTUdmin="U1386" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1663187..1663191) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1663191) /Source="Nicolas_upshifts" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1663206..1663211) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1663335 /Source="Nicolas_upshifts" /id="D937" /incds=0 /nref=26 /ntot=212 /MaxReadThrough="5.10866" /MaxDrop="4.06475" /score="17.2354231" /energy="-17" /TU="U1382,U1385" /idTUdmin="U1384" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1663531..1663803 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389617.1" /db_xref="EnsemblGenomes-Gn:BSU17350" /db_xref="EnsemblGenomes-Tr:CAB13619" /db_xref="InterPro:IPR025448" /db_xref="PDB:3KVP" /db_xref="SubtiList:BG13436" /db_xref="UniProtKB/Swiss-Prot:O31797" /translation="MFESEAELRRIRIALVWIAVFLLFGACGNQDTIIETDNGNSDYE TPQPTSFPLEHNHFGVMEDGYIKIYEYNESRNEVKLKKEYADDELE*" /label="ymzC CDS" gene 1663531..1663803 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /label="ymzC gene" promotor_-35 1663819..1663826 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1663840..1663859 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1663842 /Source="Nicolas_upshifts" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="upshifts" CDS 1663885..1664115 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389618.1" /db_xref="EnsemblGenomes-Gn:BSU17360" /db_xref="EnsemblGenomes-Tr:CAB13620" /db_xref="SubtiList:BG13434" /db_xref="UniProtKB/Swiss-Prot:O31798" /translation="MKHKVIVNHWEEICEDDSCYEYGTSIIVNGKELIREASIITALK AVLEEIGADVEIEETVESEKCCDSLRKKNLDY*" /label="ymzA CDS" gene 1663885..1664115 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /label="ymzA gene" S_feature 1664116..1664192 /Source="Nicolas_S_feature" /locus_tag="new_1868375_1868451" /HighExp="dia5, dia15, Diami, B60, G150, H2O2, LPhT, G180, G135, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S620" downshifts 1664149 /Source="Nicolas_upshifts" /id="D938" /incds=0 /nref=24 /ntot=61 /MaxReadThrough="7.47169" /MaxDrop="4.19691" /score="8.2587309" /energy="-16.9" /TU="U1385,U1387" /idTUdmin="U1385" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 1664194..1664301 /Source="Nicolas_S_feature" /locus_tag="new_1868453_1868560" /HighExp="G180, G150, G135, H2O2, dia15, Paraq, LBGexp, C30, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S621" promotor_-35 1664274..1664281 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1664295..1664314 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1664303 /Source="Nicolas_upshifts" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="upshifts" CDS 1664358..1664750 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16885274, 21561096, 22443445, 23402532, 26507228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16885274, 21561096, 22443445, 23402532, 26507228; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-factor of ribonucleotide diphosphate reductase" /protein_id="NP_389619.1" /db_xref="EnsemblGenomes-Gn:BSU17370" /db_xref="EnsemblGenomes-Tr:CAB13621" /db_xref="GOA:P50618" /db_xref="InterPro:IPR004465" /db_xref="InterPro:IPR020852" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLJ" /db_xref="SubtiList:BG11426" /db_xref="UniProtKB/Swiss-Prot:P50618" /translation="MVQIIFDSKTGNVQRFVNKTGFQQIRKVDEMDHVDTPFVLVTYT TNFGQVPASTQSFLEKYAHLLLGVAASGNKVWGDNFAKSADTISRQYQVPILHKFELS GTSKDVELFTQEVERVVTKSSAKMDPVK*" /label="nrdI CDS" gene 1664358..1664750 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /label="nrdI gene" CDS 1664710..1666812 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (major subunit)" /protein_id="NP_389620.1" /db_xref="EnsemblGenomes-Gn:BSU17380" /db_xref="EnsemblGenomes-Tr:CAB13622" /db_xref="GOA:P50620" /db_xref="InterPro:IPR000788" /db_xref="InterPro:IPR008926" /db_xref="InterPro:IPR013346" /db_xref="InterPro:IPR013509" /db_xref="InterPro:IPR013554" /db_xref="InterPro:IPR026459" /db_xref="SubtiList:BG11404" /db_xref="UniProtKB/Swiss-Prot:P50620" /translation="MSQNQVPKWIQLNNEIMIQKDGKFQFDKDKEAVHSYFVDYINQN TVFFHNLKEKLDYLVENQYYEEEFLSLYSFEDIKEVFKTAYAKKFRFPSFMSAFKFYN DYALKTNDKKKILERYEDRISIVALFFANGDTEKAKEYVNLMINQEYQPSTPTFLNAG RKRRGELVSCFLLEVNDSLNDISRAIDISMQLSKLGGGVSLNLSKLRAKGEAIKDVEN ATKGVVGVMKLLDNAFRYADQMGQRQGSGAAYLNIFHRDINDFLDTKKISADEDVRVK TLSIGVVIPDKFVELAREDKAAYVFYPHTIYKEYGQHMDEMDMNEMYDKFVDNPRVKK EKINPRKLLEKLAMLRSESGYPYIMFQDNVNKVHANNHISKVKFSNLCSEVLQASQVS SYTDYDEEDEIGLDISCNLGSLNILNVMEHKSIEKTVKLATDSLTHVSETTDIRNAPA VRRANKAMKSIGLGAMNLHGYLAQNGIAYESPEARDFANTFFMMVNFYSIQRSAEIAK EKGETFDQYEGSTYATGEYFDKYVSTDFSPKYEKIANLFEGMHIPTTEDWKKLKAFVA EHGMYHSYRLCIAPTGSISYVQSSTASVMPIMERIEERTYGNSKTYYPMPGLASNNWF FYKEAYDMDMFKVVDMIATIQQHIDQGISFTLFLKDTMTTRDLNRIDLYAHHRGIKTI YYARTKDTGQDSCLSCVV*" /label="nrdE CDS" gene 1664710..1666812 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /label="nrdE gene" CDS 1666830..1667819 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (minor subunit)" /protein_id="NP_389621.1" /db_xref="EnsemblGenomes-Gn:BSU17390" /db_xref="EnsemblGenomes-Tr:CAB13623" /db_xref="GOA:P50621" /db_xref="InterPro:IPR000358" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR026494" /db_xref="InterPro:IPR030475" /db_xref="InterPro:IPR033909" /db_xref="PDB:4DR0" /db_xref="SubtiList:BG11405" /db_xref="UniProtKB/Swiss-Prot:P50621" /translation="MTKIYDAANWSKHEDDFTQMFYNQNVKQFWLPEEIALNGDLLTW KYLGKNEQDTYMKVLAGLTLLDTEQGNTGMPIVAEHVDGHQRKAVLNFMAMMENAVHA KSYSNIFMTLAPTETINEVFEWVKQNKYLQKKAQMIVGLYKAIQKDDEISLFKAMVAS VYLESFLFYSGFYYPLYFYGQGKLMQSGEIINLILRDEAIHGVYVGLLAQEIYNKQTE EKKAELREFAIDLLNQLYENELEYTEDLYDQVGLSHDVKKFIRYNANKALMNLGFDPY FEEEDINPIVLNGLNTKTKSHDFFSMKGNGYKKATVEPLKDDDFYFEDEKEQI*" /label="nrdF CDS" gene 1666830..1667819 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /label="nrdF gene" downshifts 1667779 /Source="Nicolas_upshifts" /id="D939" /incds=0 /nref=3 /ntot=106 /MaxReadThrough="6.49299" /MaxDrop="2.8143" /score="-8.26008921" /energy="-10.8" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" S_feature complement(1667833..1668492) /Source="Nicolas_S_feature" /locus_tag="new_1872092_1872751_c" /HighExp="BT, B36, C30, Pyr, S8, G135, G/S, Glucon, B60, C90" /AntisenseName="ymaB" /AntisenseCor="-0.136438199650502" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S622" downshifts complement(1667848) /Source="Nicolas_upshifts" /id="D940" /incds=0 /nref=3 /ntot=8 /MaxReadThrough="2.78803" /MaxDrop="4.0424" /score="6.77419677" /energy="-10.8" /TU="NA" /idTUdmin="U1390" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 1667869..1668489 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885274, 21561096; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative cofactor involved in deoxyribonucleotide synthesis" /protein_id="NP_389622.1" /db_xref="EnsemblGenomes-Gn:BSU17400" /db_xref="EnsemblGenomes-Tr:CAB13624" /db_xref="GOA:P50619" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG11427" /db_xref="UniProtKB/Swiss-Prot:P50619" /translation="MGKMDEMILVAPRDDVFKKESLTFQGVYSEDSRVAEIMAQIEAA YREMRRGDAEEDPRFKQPIPYVVIKREDEVFLYERLAGGGESRLHNKLSLGFGGHMNA IEGAASFAEVLKLNTDRELEEELQINEEDKQAIVTLGLINDDENSVGKVHIGILSALQ LKPGAQVEVKEKEQIAGKWMKVSELKQDDIYNRLETWSQFVVDILE*" /label="ymaB CDS" gene 1667869..1668489 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /label="ymaB gene" downshifts 1668470 /Source="Nicolas_upshifts" /id="D941" /incds=0 /nref=130 /ntot=257 /MaxReadThrough="4.3301" /MaxDrop="6.0751" /score="31.3992458" /energy="-16.3" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-35" /isTUend="FALSE" /label="downshifts" promotor_-35 1668505..1668509 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1668527..1668894 /Source="Nicolas_S_feature" /locus_tag="new_1872786_1873153" /HighExp="dia15, G180, H2O2, G135, G150, Diami, Paraq, Oxctl, LBGexp, C30" /AntisenseName="cwlC" /AntisenseCor="-8.9131707018362205E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.231, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S623" upshifts 1668527 /Source="Nicolas_upshifts" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1668531..1668548 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1668537) /Source="Nicolas_upshifts" /id="D942" /incds=0 /nref=1 /ntot=53 /MaxReadThrough="7.25519" /MaxDrop="4.6417" /score="9.14776993" /energy="-8.9" /TU="U1390" /idTUdmin="U1390" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS complement(1668553..1669320) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /EC_number="3.5.1.28" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10515909, 10945275, 10974124, 11375403, 16042392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10515909, 10945275, 10974124, 11375403, 16042392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (sporulation-specific)" /protein_id="NP_389623.2" /db_xref="EnsemblGenomes-Gn:BSU17410" /db_xref="EnsemblGenomes-Tr:CAB13625" /db_xref="GOA:Q06320" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="PDB:1X60" /db_xref="SubtiList:BG10825" /db_xref="UniProtKB/Swiss-Prot:Q06320" /translation="MVKIFIDPGHGGSDPGATGNGLQEKTLTLQIALALRTILTNEYE GVSLLLSRTSDQYVSLNDRTNAANNWGADFFLSIHVNSGGGTGFESYIYPDVGAPTTT YQSTIHSEVIQAVDFADRGKKTANFHVLRESAMPALLTENGFIDTVSDANKLKTSSFI QSLARGHANGLEQAFNLKKTSSSGLYKVQIGAFKVKANADSLASNAEAKGFDSIVLLK DGLYKVQIGAFSSKDNADTLAARAKNAGFDAIVILES*" /label="cwlC CDS" gene complement(1668553..1669320) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /label="cwlC gene" promotor_-10 complement(1669329..1669348) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1669352) /Source="Nicolas_upshifts" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1669361..1669370) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1669474..1669479 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1669495..1669513 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1669495 /Source="Nicolas_upshifts" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1669777..1669782 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-35" promotor_-10 1669799..1669817 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-10" S_feature 1669803..1669943 /Source="Nicolas_S_feature" /locus_tag="new_1874062_1874202" /HighExp="S4, S5, S6, S8, S3, B60, LoTm, S7, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.777" /TUlongSig="NA" /TUlongPSig="NA" /label="S624" upshifts 1669803 /Source="Nicolas_upshifts" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="upshifts" CDS 1669944..1670912 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8464402, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8464402, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="mother cell sporulation ATPase" /protein_id="NP_389624.2" /db_xref="EnsemblGenomes-Gn:BSU17420" /db_xref="EnsemblGenomes-Tr:CAB13626" /db_xref="GOA:P27643" /db_xref="InterPro:IPR000641" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR014232" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11039" /db_xref="UniProtKB/Swiss-Prot:P27643" /translation="MLERAVTYKNNGQINIILNGQKQVLTNAEAEAEYQAALQKNEAK HGILKEIEKEMSALVGMEEMKRNIKEIYAWIFVNQKRAEQGLKVGKQALHMMFKGNPG TGKTTVARLIGKLFFEMNVLSKGHLIEAERADLVGEYIGHTAQKTRDLIKKSLGGILF IDEAYSLARGGEKDFGKEAIDTLVKHMEDKQHEFILILAGYSREMDHFLSLNPGLQSR FPISIDFPDYSVTQLMEIAKRMIDEREYQLSQEAEWKLKDYLMTVKSTTSPIKFSNGR FVRNVIEKSIRAQAMRLLMGDQYLKSDLMTIKSQDLSIKEEASGSA*" /label="spoVK CDS" gene 1669944..1670912 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /label="spoVK gene" downshifts 1670881 /Source="Nicolas_upshifts" /id="D943" /incds=0 /nref=5 /ntot=41 /MaxReadThrough="2.7881" /MaxDrop="5.20495" /score="22.9164064" /energy="-15.5" /TU="U1392" /idTUdmin="U1392" /TUdmin="-109" /isTUend="FALSE" /label="downshifts" promotor_-35 1670976..1670984 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-35" upshifts 1670991 /Source="Nicolas_upshifts" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="upshifts" promotor_-10 1670995..1671014 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-10" CDS 1671045..1672307 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19824612, 26458047, 26733579, 26951678, 27398305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-splitting GTPase (also ATPase, rescuingstalled ribosomes, E-site binding)" /protein_id="NP_389625.2" /db_xref="EnsemblGenomes-Gn:BSU17430" /db_xref="EnsemblGenomes-Tr:CAB13627" /db_xref="GOA:P94478" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016496" /db_xref="InterPro:IPR025121" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030394" /db_xref="InterPro:IPR032305" /db_xref="SubtiList:BG12263" /db_xref="UniProtKB/Swiss-Prot:P94478" /translation="MNEQETIQEKAILVGCQLPHITDEHFENSMEELASLTKTADGKV LTSVTQKRNRADAATYIGKGKVEELKALVEELEADLLIFNDELSPSQLKSLATAIEVK MIDRTQLILDIFAKRARTREGKLQIELAQLQYALPRLTGQGINLSRQGGGIGARGPGE TKLETDRRHIRNRIHEINTQLSTVIRHRSRYRERRKKNGVLQIALVGYTNAGKSTWFN RLTSADSYEEDLLFATLDPMTRKMVLPSGYSVLLSDTVGFIQDLPTTLIAAFRSTLEE VKEADLILHLIDSSNEDYAGHEKTVLRLLEELEADDIPMLTAYNKRDQKLPDFIPTAG RDHIMVSAKFEDDAAAFKEAIQRYLRQELLTSFEAHVPASEGKLLSRIKSETMVDRFY FNEENEQYDISGYVQEEQSIIGELKKYM*" /label="hflX CDS" gene 1671045..1672307 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /label="hflX gene" CDS 1672325..1673590 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 24610841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_389626.2" /db_xref="EnsemblGenomes-Gn:BSU17440" /db_xref="EnsemblGenomes-Tr:CAB13628" /db_xref="GOA:P94479" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR009651" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12264" /db_xref="UniProtKB/Swiss-Prot:P94479" /translation="MFDTLTHGELLKKTAMEVEADIAGIHKQIEEISERNEWRVLQSY RKHKVSDTHFTPSTGYGYDDIGRDTLESIYADVFGGEAGLVRPQIISGTHAISIALFG VLRPGDELLYITGKPYDTLEEIVGVRGGENAGSLKDFQIGYNAVDLTKDGKIDYDAVA AAINPKTKVIGIQRSKGYANRPSFLISEIKEMIRFVKEINENLIVFVDNCYGEFVEEL EPCHVGADLMAGSLIKNPGGGLAKTGGYLVGKAKWIEACSYRMTSPGIGREAGASLYS LQEMYQGFFLAPHVVSQSLKGAVFTARFLEKLGFTSNPKWDAKRTDLIQSVEFSDREK MIAFCQAIQFASPINAHVTPYPAYMPGYEDDVIMAAGTFIQGASIELSADGPIRPPYV AYVQGGLTYSHVKNAICSAVDSLMQKQLI*" /label="ynbB CDS" gene 1672325..1673590 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /label="ynbB gene" promotor_-35 1673638..1673645 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-35" promotor_-10 1673660..1673679 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-10" upshifts 1673672 /Source="Nicolas_upshifts" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="upshifts" CDS 1673700..1674107 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (nitrogen metabolism)" /protein_id="NP_389627.1" /db_xref="EnsemblGenomes-Gn:BSU17450" /db_xref="EnsemblGenomes-Tr:CAB13629" /db_xref="GOA:P37582" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4R4E" /db_xref="SubtiList:BG10424" /db_xref="UniProtKB/Swiss-Prot:P37582" /translation="MSDNIRRSMPLFPIGIVMQLTELSARQIRYYEENGLIFPARSEG NRRLFSFHDVDKLLEIKHLIEQGVNMAGIKQILAKAEAEPEQKQNEKTKKPMKHDLSD DELRQLLKNELMQAGRFQRGNTFRQGDMSRFFH*" /label="glnR CDS" gene 1673700..1674107 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /label="glnR gene" downshifts complement(1673706) /Source="Nicolas_upshifts" /id="D944" /incds=0 /nref=2 /ntot=82 /MaxReadThrough="1.78139" /MaxDrop="3.45896" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3816 /isTUend="FALSE" /label="downshifts" misc_feature 1674088..1674106 /Source="Nicolas_upshift_promotors" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1674113 /Source="Nicolas_upshifts" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1674166) /Source="Nicolas_upshifts" /id="D945" /incds=0 /nref=1 /ntot=72 /MaxReadThrough="1.70567" /MaxDrop="3.42395" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3356 /isTUend="FALSE" /label="downshifts" CDS 1674166..1675500 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /EC_number="6.3.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine synthetase" /protein_id="NP_389628.1" /db_xref="EnsemblGenomes-Gn:BSU17460" /db_xref="EnsemblGenomes-Tr:CAB13630" /db_xref="GOA:P12425" /db_xref="InterPro:IPR001637" /db_xref="InterPro:IPR004809" /db_xref="InterPro:IPR008146" /db_xref="InterPro:IPR008147" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR027302" /db_xref="InterPro:IPR027303" /db_xref="InterPro:IPR036651" /db_xref="PDB:2FWX" /db_xref="PDB:4LNF" /db_xref="PDB:4LNI" /db_xref="PDB:4LNK" /db_xref="PDB:4LNN" /db_xref="PDB:4LNO" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG10425" /db_xref="UniProtKB/Swiss-Prot:P12425" /translation="MAKYTREDIEKLVKEENVKYIRLQFTDILGTIKNVEIPVSQLGK ALDNKVMFDGSSIEGFVRIEESDMYLYPDLNTFVIFPWTAEKGKVARFICDIYNPDGT PFEGDPRNNLKRILKEMEDLGFSDFNLGPEPEFFLFKLDEKGEPTLELNDKGGYFDLA PTDLGENCRRDIVLELEEMGFEIEASHHEVAPGQHEIDFKYAGAVRSCDDIQTFKLVV KTIARKHGLHATFMPKPLFGVNGSGMHCNLSLFKNGVNAFFDENADLQLSETAKHFIA GIVKHATSFTAVTNPTVNSYKRLVPGYEAPCYVAWSAQNRSPLIRIPASRGISTRVEV RSVDPAANPYLALSVLLAAGLDGIKNKLEAPAPIDRNIYVMSKEERMENGIVDLPATL AEALEEFKSNEVMVKALGEHLFEHFIEAKEIEWDMFRTQVHPWEREQYMSQY*" /label="glnA CDS" gene 1674166..1675500 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /label="glnA gene" downshifts 1675477 /Source="Nicolas_upshifts" /id="D946" /incds=0 /nref=266 /ntot=287 /MaxReadThrough="5.53201" /MaxDrop="7.28613" /score="29.7599306" /energy="-16.4" /TU="U1394,U1395" /idTUdmin="U1393" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature 1675522..>1675571 /Source="Nicolas_S_feature" /locus_tag="new_1879781_1880041" /HighExp="Cold, BT, LBGtran, G135, G180, Etha, G150, LBGexp, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.777, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S625" SCAR 1675571..1675572 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs04" S_feature <1675572..1676324 /Source="Nicolas_S_feature" /locus_tag="new_1886528_1887351" /HighExp="Lbstat, M0t90, S8, C30, Pyr, Lbtran, M40t90, S1, M/G, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S631" promotor_-10 complement(1675664..1675682) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1675682) /Source="Nicolas_upshifts" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1675698..1675703) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1676325..1677716 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16684115, 16850406, 17183216, 20406496; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+-xyloside symporter" /protein_id="NP_389639.2" /db_xref="EnsemblGenomes-Gn:BSU17570" /db_xref="EnsemblGenomes-Tr:CAB13641" /db_xref="GOA:P94488" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12262" /db_xref="UniProtKB/Swiss-Prot:P94488" /translation="MLSENVKKISMVEKVGYASGDFACNLIYATVSTYLLFFYTDVFG LSAAAAGTMFLVVRIIDALADPFIGTIVDRTNSRFGRFRPYLLFGAFPFVILAILCFT TPDFSDMGKLIYAYITYVGLSLTYTTINVPYGALTSAMTRNNQEVVSITSVRMLFANL GGLVVAFFVPLLAAYLSDTSGNESLGWQLTMGILGMIGGCLLIFCFKSTKERVTLQKS EEKIKFTDIFEQFRVNRPLVVLSIFFIIIFGVNSISNSVGIYYVTYNLEREDLVKWYG LIGSLPALVILPFIPRLHQFLGKKKLLNYALLLNIIGLLALLFVPPSNVYLILVCRLI AAAGSLTAGGYMWALIPETIEYGEYRTGKRMGGLIYAIIGFFFKFGMALGGVVPGLVL DKFGYVANQAQTPAALMGILITTTIIPVFLLVLALIDINFYNLDEKKYKNMVRELENR DKVYLDHIDDFKA*" /label="xynP CDS" gene 1676325..1677716 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /label="xynP gene" CDS 1677747..1679348 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /EC_number="3.2.1.37" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2440680, 6413490, 7816035, 9286998, 9973552, 16684115, 28066362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylan beta-1,4-xylosidase" /protein_id="NP_389640.2" /db_xref="EnsemblGenomes-Gn:BSU17580" /db_xref="EnsemblGenomes-Tr:CAB13642" /db_xref="GOA:P94489" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="PDB:1YIF" /db_xref="SubtiList:BG11987" /db_xref="UniProtKB/Swiss-Prot:P94489" /translation="MKITNPVLKGFNPDPSICRAGEDYYIAVSTFEWFPGVQIHHSKD LVNWHLVAHPLQRVSQLDMKGNPNSGGVWAPCLSYSDGKFWLIYTDVKVVDGAWKDCH NYLVTCETINGDWSEPIKLNSSGFDASLFHDTDGKKYLLNMLWDHRIDRHSFGGIVIQ EYSDKEQKLIGKPKVIFEGTDRKLTEAPHLYHIGNYYYLLTAEGGTRYEHAATIARSA NIEGPYEVHPDNPILTSWHDPGNPLQKCGHASIVQTHTDEWYLAHLTGRPIHPDDDSI FQQRGYCPLGRETAIQKLYWKDEWPYVVGGKEGSLEVDAPSIPETIFEATYPEVDEFE DSTLNINFQTLRIPFTNELGSLTQAPNHLRLFGHESLTSTFTQAFVARRWQSLHFEAE TAVEFYPENFQQAAGLVNYYNTENWTALQVTHDEELGRILELTICDNFSFSQPLNNKI VIPREVKYVYLRVNIEKDKYYYFYSFNKEDWHKIDIALESKKLSDDYIRGGGFFTGAF VGMQCQDTSGNHIPADFRYFRYKEK*" /label="xynB CDS" gene 1677747..1679348 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /label="xynB gene" S_feature complement(1677863..1678168) /Source="Nicolas_S_feature" /locus_tag="new_1888890_1889195_c" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, S4, B36, BC" /AntisenseName="xynB" /AntisenseCor="6.2527836498644102E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S632" promotor_-10 complement(1678163..1678182) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1678168) /Source="Nicolas_upshifts" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1678196..1678204) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1679346 /Source="Nicolas_upshifts" /id="D951" /incds=0 /nref=2 /ntot=53 /MaxReadThrough="1.32947" /MaxDrop="3.8449" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1400" /TUdmin=3190 /isTUend="FALSE" /label="downshifts" CDS complement(1679485..1680639) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1588910, 1719948, 2544559, 7559331; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389641.3" /db_xref="EnsemblGenomes-Gn:BSU17590" /db_xref="EnsemblGenomes-Tr:CAB13643" /db_xref="GOA:P94490" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11986" /db_xref="UniProtKB/Swiss-Prot:P94490" /translation="MDIADQTFVKKVNQKLLLKEILKNSPISRAKLSEMTGLNKSTVS SQVNTLMKESMVFEIGQGQSSGGRRPVMLVFNKKAGYSVGIDVGVDYINGILTDLEGT IVLDQYRHLESNSPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPGLIDKDQKIVF TPNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIG IGVIINNHLYRGVSGFSGEMGHMTIDFNGPKCSCGNRGCWELYASEKALLKSLQTKEK KLSYQDIINLAHLNDIGTLNALQNFGFYLGIGLTNILNTFNPQAVILRNSIIESHPMV LNSMRSEVSSRVYSQLGNSYELLPSSLGQNAPALGMSSIVIDHFLDMITM*" /label="xylR CDS" gene complement(1679485..1680639) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /label="xylR gene" downshifts complement(1679488) /Source="Nicolas_upshifts" /id="D952" /incds=0 /nref=9 /ntot=198 /MaxReadThrough="2.56326" /MaxDrop="4.09398" /score="19.297583" /energy="-7.4" /TU="NA" /idTUdmin="U1405" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1680538..1680716) /Source="Nicolas_S_feature" /locus_tag="new_1891565_1891743_c" /HighExp="dia15, Etha, dia5, dia0, Cold, LBGstat, Lbexp, M0t45, Diami, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S633" promotor_-35 1680684..1680690 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1680699..1680718) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1680700..1680716 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1680710 /Source="Nicolas_upshifts" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1680716) /Source="Nicolas_upshifts" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1680733..1680736) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1680743..1680750 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1680765..1680784 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1680776..1680880 /Source="Nicolas_S_feature" /locus_tag="new_1891803_1891907" /HighExp="dia15, dia0, Lbexp, dia5, B60, Sw, G150, LPhT, Mt0, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S634" upshifts 1680777 /Source="Nicolas_upshifts" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="upshifts" CDS 1680881..1682218 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /EC_number="5.3.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7663444, 8132469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7663444, 8132469; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylose isomerase" /protein_id="NP_389642.2" /db_xref="EnsemblGenomes-Gn:BSU17600" /db_xref="EnsemblGenomes-Tr:CAB13644" /db_xref="GOA:P0CI80" /db_xref="InterPro:IPR001998" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR013452" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG10806" /db_xref="UniProtKB/Swiss-Prot:P0CI80" /translation="MAQSHSSSINYFGSANKVVYEGKDSTNPLAFKYYNPQEVIGGKT LKEHLRFSIAYWHTFTADGTDVFGAATMQRPWDHYKGMDLAKMRVEAAFEMFEKLDAP FFAFHDRDIAPEGSTLKETNQNLDMIMGMIKDYMRNSGVKLLWNTANMFTNPRFVHGA ATSCNADVFAYAAAQVKKGLETAKELGAENYVFWGGREGYETLLNTDLKFELDNLARF MHMAVDYAKEIGYTGQFLIEPKPKEPTTHQYDTDAATTIAFLKQYGLDNHFKLNLEAN HATLAGHTFEHELRMARVHGLLGSVDANQGHPLLGWDTDEFPTDLYSTTLAMYEILQN GGLGSGGLNFDAKVRRSSFEPDDLIYAHIAGMDAFARGLKVAHKLIEDRVFEDVIQHR YRSFTEGIGLEIIEGRANFHTLEQYALNHKSIKNESGRQEKLKAILNQYILEV*" /label="xylA CDS" gene 1680881..1682218 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /label="xylA gene" S_feature 1682219..1682293 /Source="Nicolas_S_feature" /locus_tag="new_1893246_1893320" /HighExp="dia0, dia15, Sw, Lbexp, dia5, B60, Mt0, M0t45, G150, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S635" downshifts 1682250 /Source="Nicolas_upshifts" /id="D953" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="4.89699" /MaxDrop="3.40404" /score="13.0570501" /energy="-10.2" /TU="U1406" /idTUdmin="U1406" /TUdmin="-1892" /isTUend="FALSE" /label="downshifts" CDS 1682369..1683868 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /EC_number="2.7.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1660563, 8866023, 27467131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylulose kinase" /protein_id="NP_389643.1" /db_xref="EnsemblGenomes-Gn:BSU17610" /db_xref="EnsemblGenomes-Tr:CAB13645" /db_xref="GOA:P39211" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006000" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10807" /db_xref="UniProtKB/Swiss-Prot:P39211" /translation="MKYVIGIDLGTSAVKTILVNQNGKVCAETSKRYPLIQEKAGYSE QNPEDWVQQTIEALAELVSISNVQAKDIDGISYSGQMHGLVLLDQDRQVLRNAILWND TRTTPQCIRMTEKFGDHLLDITKNRVLEGFTLPKMLWVKEHEPELFKKTAVFLLPKDY VRFRMTGVIHTEYSDAAGTLLLHITRKEWSNDICNQIGISADICPPLVESHDCVGSLL PHVAAKTGLLEKTKVYAGGADNACGAIGAGILSSGKTLCSIGTSGVILSYEEEKERDF KGKVHFFNHGKKDSFYTMGVTLAAGYSLDWFKRTFAPNESFEQLLQGVEAIPIGANGL LYTPYLVGERTPHADSSIRGSLIGMDGAHNRKHFLRAIMEGITFSLHESIELFREAGK SVHTVVSIGGGAKNDTWLQMQADIFNTRVIKLENEQGPAMGAAMLAAFGSGWFESLEE CAEQFIREAAAFYPKAQNVQKYKTLFDLYKNIYTHTKDLNTALKSFRKN*" /label="xylB CDS" gene 1682369..1683868 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /label="xylB gene" S_feature 1683869..1684184 /Source="Nicolas_S_feature" /locus_tag="new_1894896_1895211" /HighExp="dia0, dia15, Lbexp, dia5, Mt0, M0t45, G150, Etha, Diami, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.51323200000000002" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S636" downshifts 1684142 /Source="Nicolas_upshifts" /id="D954" /incds=0 /nref=60 /ntot=197 /MaxReadThrough="0.61776" /MaxDrop="5.13425" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1406" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1684351..1684986) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11584000" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11584000; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA nuclease, lipoprotein (phage origin)" /protein_id="NP_389644.1" /db_xref="EnsemblGenomes-Gn:BSU17620" /db_xref="EnsemblGenomes-Tr:CAB13646" /db_xref="GOA:P94492" /db_xref="InterPro:IPR002071" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR035437" /db_xref="SubtiList:BG12265" /db_xref="UniProtKB/Swiss-Prot:P94492" /translation="MKKILISMIAIVLSITLAACGSNHAAKNHSDSNGTEQVSQDTHS NEYNQTEQKAGTPHSKNQKKLVNVTLDRAIDGDTIKVIYNGKKDTVRYLLVDTPETKK PNSCVQPYGEDASKRNKELVNSGKLQLEFDKGDRRDKYGRLLAYVYVDGKSVQETLLK EGLARVAYVYEPNTKYIDQFRLDEQEAKSDKLSIWSKSGYVTNRGFNGCVK*" /label="yncB CDS" gene complement(1684351..1684986) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /label="yncB gene" promotor_-10 complement(1685023..1685042) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1685032) /Source="Nicolas_upshifts" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1685057..1685064) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1685174..1685181 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1685196..1685215 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1685198..1685396 /Source="Nicolas_S_feature" /locus_tag="new_1896225_1896423" /HighExp="T0.30H, Lbtran, T1.0H, M9-stat, M0t90, T1.30H, M40t90, T2.0H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S637" upshifts 1685198 /Source="Nicolas_upshifts" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="upshifts" CDS 1685397..1686812 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22900538, 23569278; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar transporter" /protein_id="NP_389645.2" /db_xref="EnsemblGenomes-Gn:BSU17630" /db_xref="EnsemblGenomes-Tr:CAB13647" /db_xref="GOA:P94493" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12266" /db_xref="UniProtKB/Swiss-Prot:P94493" /translation="MDMNEHRNRRLKLIMISATFGGLLFGYDTGVINGALPFMARPDQ LDLTPVTEGLVTSILLLGAAFGALLCGRLADRYGRRKMILNLSFLFFLASLGTALAPN VFIMAVFRFLLGLAVGGASAMVPAFLAEMAPHEKRGRMVTQNELMIVGGQFLAYVFNA ILGVTMANTGHVWRYMLVICAVPAIMLFASMLKVPESPRWLISKGKNSEALRVLKQIR EDKRAEAECREIQEAVEKDTALEKASLKDFSTPWLRRLLWIGIGVAIVNQITGVNSIM YYGTQILKESGFGTKAALIANIGNGLISVIAVIFGIWLVGKVRRRPILLIGLAGTTTA LLLIAIFSIVLDGSMALPYVVLSLTVLFLAFMQGCVGPVTWLVIAEIFPQRLRGLGSG ISVFFLWILNFVIGFAFPILLSSVGLSFTFFIFVALGVLAIGFVYKFMPETKGRTLEE LEEHFRSRHDHNTPEQSVIEV*" /label="yncC CDS" gene 1685397..1686812 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /label="yncC gene" downshifts 1686802 /Source="Nicolas_upshifts" /id="D955" /incds=0 /nref=13 /ntot=69 /MaxReadThrough="0.90595" /MaxDrop="4.35189" /score="15.579587" /energy="-8.6" /TU="NA" /idTUdmin="U1408" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts complement(1686905) /Source="Nicolas_upshifts" /id="D956" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="1.08869" /MaxDrop="5.39832" /score="24.3759796" /energy="-9.3" /TU="NA" /idTUdmin="U1409" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(1686914..1688098) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /EC_number="5.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10348844, 18399999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10348844, 18399999; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanine racemase (minor activity)" /protein_id="NP_389646.1" /db_xref="EnsemblGenomes-Gn:BSU17640" /db_xref="EnsemblGenomes-Tr:CAB13648" /db_xref="GOA:P94494" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="PDB:5IRP" /db_xref="SubtiList:BG12267" /db_xref="UniProtKB/Swiss-Prot:P94494" /translation="MIKLCREVWIEVNLDAVKKNLRAIRRHIPHKSKIMAVVKANGYG HGSIEVARHALEHGASELAVASVEEGIVLRKAGITAPILVLGFTSLSCVKKSAAWNIT LSAFQVDWMKEANEILEKEASANRLAIHINVDTGMGRLGVRTKEELLEVVKALKASKF LRWTGIFTHFSTADEPDTTLTKLQHEKFISFLSFLKKQGIELPTVHMCNTAAAIAFPE FSADMIRLGIGLYGLYPSAYIKQLNLVKLEPALSLKARIAYVKTMRTEPRTVSYGATY IAEPNEVIATLPIGYADGYSRALSNRGFVLHRGKRVPVAGRVTMDMIMVSLGENGEGK QGDEVVIYGKQKGAEISVDEVAEMLNTINYEVVSTLSRRIPRFYIRDGEIFKVSTPVL YV*" /label="alrB CDS" gene complement(1686914..1688098) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /label="alrB gene" S_feature complement(1688099..1688178) /Source="Nicolas_S_feature" /locus_tag="new_1899126_1899205_c" /HighExp="S4, S5, S3, S6, S7, B36, BT, S8, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.908" /TUlongSig="NA" /TUlongPSig="NA" /label="S638" promotor_-10 complement(1688171..1688189) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1688182) /Source="Nicolas_upshifts" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1688205..1688210) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1688490..1688497 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1688512..1688531 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1688520 /Source="Nicolas_upshifts" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1688562..1689023 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative prophage protein" /protein_id="NP_389648.2" /db_xref="EnsemblGenomes-Gn:BSU17650" /db_xref="EnsemblGenomes-Tr:CAB13649" /db_xref="InterPro:IPR020216" /db_xref="SubtiList:BG12268" /db_xref="UniProtKB/Swiss-Prot:P94495" /translation="MNRGVSFQIPNEYGNFLWRILQPVEIANYRWQTSGESYFVVEGE LDDEELFHDYEIVEGAVFEQQLKTNQYYTIFVELKAFPYGKMVNQVNTYEEFADSDCE LVLLIADNSYVSIYCKNKNIIEKLYFNALQHDFEDVQFITDENDTRTSLTV*" /label="yncE CDS" gene 1688562..1689023 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /label="yncE gene" CDS 1689053..1689487 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /EC_number="3.6.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11375514, 15939294, 16908222, 17169987, 21358047, 23897460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11375514, 15939294, 16908222, 17169987, 21358047, 23897460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="deoxyuridine 5'-triphosphate pyrophosphatase (phage origin)" /protein_id="NP_389649.1" /db_xref="EnsemblGenomes-Gn:BSU17660" /db_xref="EnsemblGenomes-Tr:CAB13650" /db_xref="GOA:O31801" /db_xref="InterPro:IPR029054" /db_xref="InterPro:IPR033704" /db_xref="InterPro:IPR036157" /db_xref="PDB:2XCD" /db_xref="PDB:2XCE" /db_xref="PDB:4AOO" /db_xref="PDB:4AOZ" /db_xref="PDB:4APZ" /db_xref="PDB:4B0H" /db_xref="SubtiList:BG13437" /db_xref="UniProtKB/Swiss-Prot:O31801" /translation="MTMQIKIKYLDETQTRISKIEQGDWIDLRAAEDVTIKKDEFKLV PLGVAMELPEGYEAHVVPRSSTYKNFGVIQTNSMGVIDESYKGDNDFWFFPAYALRDT EIKKGDRICQFRIMKKMPAVELVEVEHLGNEDRGGLGSTGTK*" /label="dutA CDS" gene 1689053..1689487 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /label="dutA gene" S_feature complement(1689236..1689541) /Source="Nicolas_S_feature" /locus_tag="new_1900263_1900568_c" /HighExp="LoTm, S5, T5.0H, S8, T4.0H, S4, S7, T3.30H, Cold, T-4.40H" /AntisenseName="yncF" /AntisenseCor="-0.40042805081531202" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S639" downshifts 1689334 /Source="Nicolas_upshifts" /id="D957" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.18195" /MaxDrop="2.2821" /score="0.171090809" /energy="-9.3" /TU="U1410" /idTUdmin="U1408" /TUdmin=2530 /isTUend="FALSE" /label="downshifts" S_feature 1689488..1690584 /Source="Nicolas_S_feature" /locus_tag="new_1900515_1901611" /HighExp="S8, G150, G180, dia0, G135, UNK1, MG 15, Lbexp, Fru, S7" /AntisenseName="cotU" /AntisenseCor="-0.266961200384908" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S640" S_feature complement(1689543..1689828) /Source="Nicolas_S_feature" /locus_tag="new_1900570_1900855_c" /HighExp="LoTm, dia5, dia15, T3.30H, T3.0H, T-4.40H, T4.0H, T5.0H, T-3.40H, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25207000000000002" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S641" downshifts complement(1689586) /Source="Nicolas_upshifts" /id="D958" /incds=0 /nref=2 /ntot=95 /MaxReadThrough="4.29622" /MaxDrop="2.9464" /score="11.6697365" /energy="-9.7" /TU="U1411" /idTUdmin="U1411" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1689823..1689842) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1689828) /Source="Nicolas_upshifts" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1689854..1689859) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1690090) /Source="Nicolas_upshifts" /id="D959" /incds=0 /nref=17 /ntot=130 /MaxReadThrough="2.07509" /MaxDrop="8.56023" /score="11.6697365" /energy="-9.7" /TU="NA" /idTUdmin="U1412" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1690090..1690350) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12562816, 18065538, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 18065538, 20023017; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389650.1" /db_xref="EnsemblGenomes-Gn:BSU17670" /db_xref="EnsemblGenomes-Tr:CAB13651" /db_xref="GOA:O31802" /db_xref="SubtiList:BG13471" /db_xref="UniProtKB/Swiss-Prot:O31802" /translation="MGYYKKYKEEYYTWKKTYYKKYYDNDKKHYDCDKYYDHDKKHYD YDKKYDDHDKKYYDDHDYHYEKKYYDDDDHYYDFVESYKKHH*" /label="cotU CDS" gene complement(1690090..1690350) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /label="cotU gene" promotor_-10 complement(1690371..1690390) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1690381) /Source="Nicolas_upshifts" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1690403..1690412) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1690585..1690710 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein (putative phage origin)" /db_xref="PSEUDO:CAX52624.1" /translation="MNVMVKIQELYDVIFHTAFEGFRVRHQKQTAKPARNRSYKE*" /label="ynzJ CDS" gene 1690585..1690710 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /pseudo /label="ynzJ gene" S_feature 1690711..1690827 /Source="Nicolas_S_feature" /locus_tag="new_1901738_1901854" /HighExp="G180, G135, G150, dia0, UNK1, S8, Lbexp, C90, MG 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S642" CDS 1690754..1690918 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein from phage origin" /protein_id="YP_009513957.1" /translation="MKLERIYFKESPIAHGQMTIDIEVKYNALNQKKLLEDLMCLDNF QFGIHKHLTI*" /label="conserved hypothetical protein from phage origin CDS" gene 1690754..1690918 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /label="gene" promotor_-35 1690802..1690811 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1690825..1690844 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1690829..1691139 /Source="Nicolas_S_feature" /locus_tag="new_1901856_1902166" /HighExp="S7, S6, S8, S5, BT, G/S, Pyr, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.585202" /TUshortSig="SigK, SigA" /TUshortPSig="0.935, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S643" upshifts 1690829 /Source="Nicolas_upshifts" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1691120..1691127 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1691141..1691160 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1691141 /Source="Nicolas_upshifts" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1691192..1692031 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:416889, 418407, 9648749, 10091656, 10574451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 416889, 418407, 9648749, 10091656, 10574451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase A (phage origin)" /protein_id="NP_389651.1" /db_xref="EnsemblGenomes-Gn:BSU17680" /db_xref="EnsemblGenomes-Tr:CAB13652" /db_xref="GOA:P0CI79" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="PDB:1B02" /db_xref="PDB:1BKO" /db_xref="PDB:1BKP" /db_xref="PDB:1BSF" /db_xref="PDB:1BSP" /db_xref="SubtiList:BG11190" /db_xref="UniProtKB/Swiss-Prot:P0CI79" /translation="MTQFDKQYNSIIKDIINNGISDEEFDVRTKWDSDGTPAHTLSVI SKQMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNMMGVHIWDQWKQEDG TIGHAYGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTP CVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNI GDCHVYTRHIDNLKIQMEREQFEAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFE VAV*" /label="thyA CDS" gene 1691192..1692031 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /label="thyA gene" promotor_-10 complement(1691214..1691233) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1691235) /Source="Nicolas_upshifts" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1691248..1691251) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1691991 /Source="Nicolas_upshifts" /id="D960" /incds=0 /nref=6 /ntot=143 /MaxReadThrough="4.34299" /MaxDrop="3.3234" /score="1.39203037" /energy="-7.7" /TU="U1410,U1414" /idTUdmin="U1413" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" downshifts complement(1692137) /Source="Nicolas_upshifts" /id="D961" /incds=0 /nref=6 /ntot=150 /MaxReadThrough="3.28185" /MaxDrop="3.73135" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1417" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" S_feature complement(1692138..1692444) /Source="Nicolas_S_feature" /locus_tag="new_1903165_1903471_c" /HighExp="LBGstat, Lbstat, LoTm, B60, LPhT, M9-stat, T1.30H, B36, nit, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99924299999999999" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S644" CDS complement(1692154..1692441) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513958.1" /translation="MEHTGHSSFLQLFCLNLTLIRVEIGMKYEKTSLFGMILVIVALL ISIYFMCNTNALIPAGYDLAIHGIVISRTVMIAFTLYLVSKLGYFLLNKKD*" /label="conserved protein of unknown function CDS" gene complement(1692154..1692441) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /label="gene" downshifts complement(1692181) /Source="Nicolas_upshifts" /id="D962" /incds=0 /nref=2 /ntot=85 /MaxReadThrough="3.82042" /MaxDrop="6.47995" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1418" /TUdmin=308 /isTUend="FALSE" /label="downshifts" promotor_-35 1692268..1692276 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1692290..1692309 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1692292 /Source="Nicolas_upshifts" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="upshifts" S_feature 1692303..1692463 /Source="Nicolas_S_feature" /locus_tag="new_1903330_1903490" /HighExp="S8, S6, S7, BT, S5, S4, S3, Pyr, G/S, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S645" downshifts 1692435 /Source="Nicolas_upshifts" /id="D963" /incds=0 /nref=13 /ntot=53 /MaxReadThrough="1.26429" /MaxDrop="5.75919" /score="7.35184753" /energy="-11.1" /TU="NA" /idTUdmin="U1416" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1692484..1693206) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_389652.2" /db_xref="EnsemblGenomes-Gn:BSU17690" /db_xref="EnsemblGenomes-Tr:CAB13653" /db_xref="GOA:O31803" /db_xref="InterPro:IPR029143" /db_xref="PDB:4HFS" /db_xref="SubtiList:BG13438" /db_xref="UniProtKB/Swiss-Prot:O31803" /translation="MVKKVLIAGAVGTAVLFGTLSSGIPGLPAADAQVAKAASELPNG IGGRVYLNSTGAVFTAKIVLPETVKNNDSVSTPYIYSGFRATSGTEADIGLQYSKQYN VWKPLMKVGSKNEETYIEGKDKFTYNKGFRPGSTVQMTIYKNLSGNTRMTLWGTNNDG YTGRIITEIQGTNIGTISKWKTLATAAVSYESQRDAIKATFSTSFNNITIDNKAVTPV VDTQDFAKVSVAGNNVTISVNK*" /label="yncM CDS" gene complement(1692484..1693206) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /label="yncM gene" downshifts complement(1692489) /Source="Nicolas_upshifts" /id="D964" /incds=0 /nref=31 /ntot=133 /MaxReadThrough="5.62856" /MaxDrop="4.3658" /score="0.425084384" /energy="-11.1" /TU="U1417" /idTUdmin="U1418" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1693231..1693250) /Source="Nicolas_upshift_promotors" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1693239) /Source="Nicolas_upshifts" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1693241..1693365) /Source="Nicolas_S_feature" /locus_tag="new_1904268_1904392_c" /HighExp="H2O2, dia15, S8, G180, G150, Paraq, Oxctl, LBGstat, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S646" CDS complement(1693366..1693722) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function (phage origin)" /protein_id="YP_003097731.1" /db_xref="EnsemblGenomes-Gn:BSU17699" /db_xref="EnsemblGenomes-Tr:CAX52625" /db_xref="GOA:C0H417" /db_xref="InterPro:IPR025621" /db_xref="UniProtKB/Swiss-Prot:C0H417" /translation="MYRNIVFYLILLCLFISVVMKSFEVIRTIANVICFIFVLLYFKD EMKTYSRKALAILSICFLFLVGICAFIILQGQTLMKRHLFFTGLETIAGILLIIVSLS ICTFILRKISNRLKRM*" /label="ynzK CDS" gene complement(1693366..1693722) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /label="ynzK gene" promotor_-10 complement(1693746..1693765) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1693763) /Source="Nicolas_upshifts" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1693781..1693785) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1693962) /Source="Nicolas_upshifts" /id="D965" /incds=0 /nref=58 /ntot=194 /MaxReadThrough="0.902090000000001" /MaxDrop="9.00312" /score="34.0680178" /energy="-10.8" /TU="NA" /idTUdmin="U1419" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1693968..1694168) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389653.2" /db_xref="EnsemblGenomes-Gn:BSU17700" /db_xref="EnsemblGenomes-Tr:CAB13654" /db_xref="GOA:P07790" /db_xref="SubtiList:BG10492" /db_xref="UniProtKB/Swiss-Prot:P07790" /translation="MGYYKKYKEEYYTVKKTYYKKYYEYDKKDYDCDYDKKYDDYDKK YYDHDKKDYDYVVEYKKHKKHY*" /label="cotC CDS" gene complement(1693968..1694168) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /label="cotC gene" downshifts 1694151 /Source="Nicolas_upshifts" /id="D966" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="1.37504" /MaxDrop="5.08099" /score="-4.2739983" /energy="-8" /TU="NA" /idTUdmin="U1416" /TUdmin=1716 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1694190..1694209) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1694202) /Source="Nicolas_upshifts" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1694222..1694231) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1694343..1694531) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10974125, 11007775, 26239117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974125, 11007775, 26239117; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_389654.1" /db_xref="EnsemblGenomes-Gn:BSU17710" /db_xref="EnsemblGenomes-Tr:CAB13655" /db_xref="GOA:O31804" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG13464" /db_xref="UniProtKB/Swiss-Prot:O31804" /translation="MELSFTKILVILFVGFLVFGPDKLPALGRAAGKALSEFKQATSG LTQDIRKNDSENKEDKQM*" /label="tatAC CDS" gene complement(1694343..1694531) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /label="tatAC gene" downshifts complement(1694359) /Source="Nicolas_upshifts" /id="D967" /incds=0 /nref=213 /ntot=254 /MaxReadThrough="3.38696" /MaxDrop="6.07983" /score="8.58114058" /energy="-11" /TU="U1420,U1421" /idTUdmin="U1420" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" misc_feature complement(1694500..1694507) /Source="Nicolas_upshift_promotors" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1694513) /Source="Nicolas_upshifts" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1694560..1694579) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1694578) /Source="Nicolas_upshifts" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1694594..1694601) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1694610..1694747 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513959.1" /translation="MNILKPAQRRIHKTAAAEYNVQCHLPKKQEAGWINYVALPEMIQ T*" /label="hypothetical protein CDS" gene 1694610..1694747 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /label="gene" promotor_-35 1694641..1694646 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1694661..1694679 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1694679..1694781 /Source="Nicolas_S_feature" /locus_tag="new_1905706_1905808" /HighExp="S3, S4, LoTm, BT, B36, S5, S7, S6, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.35884500000000003" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S647" upshifts 1694679 /Source="Nicolas_upshifts" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="upshifts" CDS 1694782..1695180 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein of unknown function" /protein_id="NP_389655.1" /db_xref="EnsemblGenomes-Gn:BSU17720" /db_xref="EnsemblGenomes-Tr:CAB13656" /db_xref="SubtiList:BG13439" /db_xref="UniProtKB/Swiss-Prot:O31805" /translation="MRFTKVVGFLSVLGLAAVFPLTAQAEKAGTAGAGEWDKLGTYTY TYSSPTVYSTGGDFRVCLSGSTPFSVSLHLYEDDPGDNPDDYVGANYFSPGECHTFGS IGKFVDGSNNKAEFFVTDYSGKSKTVTFYD*" /label="yndA CDS" gene 1694782..1695180 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /label="yndA gene" S_feature 1695181..1695985 /Source="Nicolas_S_feature" /locus_tag="new_1906208_1907012" /HighExp="LoTm, S3, BT, S4, B36, S6, S5, S7, S8, T5.0H" /AntisenseName="yndB" /AntisenseCor="-0.559713635360228" /AntisenseRegPval="-22.9" /CDS_PredictionProba="0.91098199999999996" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S648" CDS complement(1695245..1695679) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /experiment="publication(s) with functional evidences, PMID:20818668, 28160315" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20818668, 28160315; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of stress-related ATPase (flavonoid-sensing)" /protein_id="NP_389656.1" /db_xref="EnsemblGenomes-Gn:BSU17730" /db_xref="EnsemblGenomes-Tr:CAB13657" /db_xref="GOA:O31806" /db_xref="InterPro:IPR013538" /db_xref="InterPro:IPR023393" /db_xref="PDB:2KEW" /db_xref="PDB:2KTE" /db_xref="SubtiList:BG13440" /db_xref="UniProtKB/Swiss-Prot:O31806" /translation="MAQNNENALPDITKSITLEAPIQKVWETVSTSEGIAKWFMPNDF QLKEGQEFHLQSPFGPSPCKVLAVQAPTELSFEWDTEGWVVTFQLEDLGEKTGFTLIH SGWKEPNEVIGKANEKSSVVRGKMDGGWTGIVNERLRKAVEE*" /label="flvS CDS" gene complement(1695245..1695679) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /label="flvS gene" downshifts complement(1695261) /Source="Nicolas_upshifts" /id="D968" /incds=0 /nref=213 /ntot=253 /MaxReadThrough="1.7995" /MaxDrop="6.63594" /score="29.1580701" /energy="-7" /TU="NA" /idTUdmin="U1423" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1695709..1695728) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1695725) /Source="Nicolas_upshifts" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1695742..1695749) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1695986..1696174 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846" /codon_start=1 /transl_table=11 /product="conserved protein involved in spore germination" /protein_id="NP_389657.2" /db_xref="EnsemblGenomes-Gn:BSU17740" /db_xref="EnsemblGenomes-Tr:CAB13658" /db_xref="SubtiList:BG13465" /db_xref="UniProtKB/Swiss-Prot:O31807" /translation="MLGKIKAAIDNSPGKPARILVSEKAFQQLEEEMRFVYVSKPKTI MGIPVEVSDQAESFKLEF*" /label="ynzB CDS" gene 1695986..1696174 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /label="ynzB gene" S_feature 1696175..1696260 /Source="Nicolas_S_feature" /locus_tag="new_1907202_1907287" /HighExp="LoTm, BT, S4, S6, S3, S8, S7, B36, S5, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S649" downshifts 1696219 /Source="Nicolas_upshifts" /id="D969" /incds=0 /nref=7 /ntot=89 /MaxReadThrough="2.20002" /MaxDrop="4.21414" /score="19.5879917" /energy="-11.9" /TU="NA" /idTUdmin="U1422" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1696289..1696295 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1696307..1696466 /Source="Nicolas_S_feature" /locus_tag="new_1907334_1907493" /HighExp="S8, S4, S6, S7, S5, S3, BT, ferm, LoTm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.95681300000000002" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S650" upshifts 1696307 /Source="Nicolas_upshifts" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1696309..1696320 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1696467..1698029 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10762253, 27208128; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_389658.1" /db_xref="EnsemblGenomes-Gn:BSU17750" /db_xref="EnsemblGenomes-Tr:CAB13659" /db_xref="GOA:O31808" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG13441" /db_xref="UniProtKB/Swiss-Prot:O31808" /translation="MMRWRNNQYKTQKQHKSDYSTAEKQDQDVLTGNIGYDLEHVKRK IGHNGDVHFRELEITQLHVKAALIFVEGLSDQDLINKGLSVLVMNQPNQVSDEISQSG KGILTSKQIKNQIVSIGDVIDSEKISDIVLNVFMGSTALLIDGIPQAFLLGTVKKQNR SIEEPLSEALVRGPRTGFTEELSTNTALLRQQGKNDQLTLQRFEVGTRLKKDLIIAYM NDIADPKVVEEVRKRVRGIEIDHLPESGYVEQLIEDNYLSPFPQVQSTERPDRVISGL MEGRVAILLDGTPFALIVPVTFSMMLQSPEDYYERWFPSSLIRLLRFIAAMITLFAPA LYISFISFHPGLIPTKLAISISGTRQGVPFPSLIEALFMEVAIEILREAGLRLPKPIG PAIGIVGGLIIGEAAVQAGIVSPIMVIVVALTAISSFAIPHYSTGIALRMLRFGAMFC AAVFGLFGVIMYYLLLSSHVVKLKSFGVPYASPAVPYHLKDWKDFVIRMPLLVMKRRP KMMNTDNTKRVK*" /label="yndD CDS" gene 1696467..1698029 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /label="yndD gene" promotor_-10 complement(1696770..1696789) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1696779) /Source="Nicolas_upshifts" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1696804..1696811) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1698059..1699150 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane protein" /protein_id="NP_389659.1" /db_xref="EnsemblGenomes-Gn:BSU17760" /db_xref="EnsemblGenomes-Tr:CAB13660" /db_xref="GOA:O31809" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG13442" /db_xref="UniProtKB/Swiss-Prot:O31809" /translation="MFSPTSKITTAQATIIIINYMLAAGVLTLPRTVTEQTQSPDGWI SVLLGGVLAVIAGMIIAKLSQQYPKETFYEYSRHIVGKWLGHLISIVFITYFLALGAF EVRVMSEIVDFFLLEGTPSWAIIMTVLWIGLYSITQGLDPIARLFEMIFPITVIIFLT IALMSLGIFEINNLRPVLGDGIMPVLRGVKTTNLSFTCSEIMFILVAFMKKPKNAVKA VVIGTGVVTSFYMITMIMVIGALSVEGVVTRTWPGLDLMRSFEIPGLIFERFESFLLV IWIMQLFATFIITFYAASLGVSQVFKKKPLSCMFGLLPVIYILSCMPKNENDVFILGD TVSHIALYIFGALPILLLVISKWRKRGEK*" /label="yndE CDS" gene 1698059..1699150 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /label="yndE gene" CDS 1699140..1700354 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 27208128; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative spore germination lipoprotein" /protein_id="NP_389660.1" /db_xref="EnsemblGenomes-Gn:BSU17770" /db_xref="EnsemblGenomes-Tr:CAB13661" /db_xref="GOA:O31810" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG13443" /db_xref="UniProtKB/Swiss-Prot:O31810" /translation="MKSKLKRQLPAMVIVCLLMICVTGCWSSREIEDLGLTFAIAIDK GKETNTEKELKEEGGSYPKKDNITLTYQFVNEKAAGAGTSGGGGSGQGAQKAYINISE TGDSLQQIGSEVALRRDREVFSPHLKVVVMSEDVLHTFPIDEMLDQFFRDNEIRLSCL VLSAKGEARDALQLKENGEIPAFRLIGLGENEHKVSRILPPMTLAKLIGKLHSGSSFL LQNVVAANGAVKYSGAAVINGKSKKMIGTLNEYETEGITWIRGEGKGGVVKSHDKKSQ QTLAYDINKIKSRIQPIVKGKDISFHVDIESEGDLVENWNTKEALDTQFIDRLETTIE NEVKKIVGQVLKKIQHDYKADVAGFDESFRLTYPHLWKRVKNNWDDTFSKADITYSVN VTITHFGTVKTQ*" /label="yndF CDS" gene 1699140..1700354 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /label="yndF gene" promotor_-35 1700432..1700439 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1700454..1700473 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1700465 /Source="Nicolas_upshifts" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="upshifts" CDS 1700501..1701307 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11737947, 22333191, 27435445" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389661.1" /db_xref="EnsemblGenomes-Gn:BSU17780" /db_xref="EnsemblGenomes-Tr:CAB13662" /db_xref="GOA:O31811" /db_xref="SubtiList:BG13444" /db_xref="UniProtKB/Swiss-Prot:O31811" /translation="MRQKPIYVEIEMKSDLDTLWEYTQNPSLHKEWDLRFSNITYLNS QPCEKQKFLYETRVGFGLKVSGTGETVGVFNKCSSERSSSLAFGSDHPLSLIRHGSGY WKYIQRENGKMTFLTQYQYKTAYGLLGRWIDRLLFRPLLGWATAWSFDALRLWVEQNK HPKRFIRSAIIYVFMCLFFSLFWFYQGFAGVKTSILTGTAEIGLAILWLLPLKRKWII HGVQACIFAGFACLGSEIFMWVLLSVFSAASGALSLQLPSARRTKRKRKK*" /label="yndG CDS" gene 1700501..1701307 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /label="yndG gene" S_feature complement(1701115..1702213) /Source="Nicolas_S_feature" /locus_tag="new_1912142_1913240_c" /HighExp="S8, S6, S7, S5, T0.30H, T2.0H, GM 150, BT, T1.30H, T-4.40H" /AntisenseName="yndH" /AntisenseCor="-0.58089150558713998" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S651" CDS 1701312..1701929 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389662.1" /db_xref="EnsemblGenomes-Gn:BSU17790" /db_xref="EnsemblGenomes-Tr:CAB13663" /db_xref="InterPro:IPR025311" /db_xref="SubtiList:BG13445" /db_xref="UniProtKB/Swiss-Prot:O31812" /translation="MSSIYEKSIINYHLLHPKLQKRYQLDGSHTFSGTGTMSEISGGS FLVRMLLKLGVFFRCFFSERGKDIPFTIQNRTCLLKSQHTGIEWNRTFFFKGKKRFFD ALMIYDEKENRILDFFGKPHLLLSVLTFEASLDGSLTITSGKQWLLICGKRIPLPKWL TGTSEVCETFDEKKNCFTIEVHVQNTILGTLFFYKGTFQEEERES*" /label="yndH CDS" gene 1701312..1701929 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /label="yndH gene" CDS 1701926..1703566 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618455, 15849754, 16850406, 28615734; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389663.1" /db_xref="EnsemblGenomes-Gn:BSU17800" /db_xref="EnsemblGenomes-Tr:CAB13664" /db_xref="GOA:O31813" /db_xref="InterPro:IPR025450" /db_xref="SubtiList:BG13446" /db_xref="UniProtKB/Swiss-Prot:O31813" /translation="MKRNGIVSALCFIGFLAAEAPDISVAEALVLLSILFFVPGIFPF VFRQSPVRAAQFMENGLIQCYPVAAFFAVLALVTEVGGFALIWWMYTVFNALYAILRL WETKIHRIEETSVLFGLIYLAGGGFWFFAYAAHLQIMQFGPLIILLTAVHFHYSAFLI PIFNGLLGRTIRKHRMLYSWITWVILLSPLLIALGITYSKTLDVIAVSIYMAAIYLHA FLVFTAAFRTKTGTFLIRLSSAVLMITIAFSMIYSFGVFRQEVTLTINQMIWIHGFVN AFGVILPALIGWRIEDAKPFDADSVKTFSRIYGKRKIGEEFLANIQAENNARYSGLVD DMGSLRSKDFSPEKLAPLILSFYEQTIEYNIKAKVTWSTWFRPLAIIYEWFSRRIGQI HLSTNPDWYRMYSKIKGVHSKKDGRERVRAWIRTNEKNETIFTALYSVYRSNGEGYMN ISLPLPFSSMTGILKPYHHQEKLVLTSRRRKSRAGDEGIYLQTRAGTCPLPLSETFLI EAVHDNKLTAVHHMWLFGIKFLTVHYSITHINQPIERT*" /label="yndJ CDS" gene 1701926..1703566 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /label="yndJ gene" promotor_-10 complement(1702200..1702219) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1702213) /Source="Nicolas_upshifts" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1702233..1702241) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1703206..1703972) /Source="Nicolas_S_feature" /locus_tag="new_1914233_1914999_c" /HighExp="T2.0H, T1.30H, T2.30H, GM 150, T3.30H, T1.0H, C30, T3.0H, T4.0H, T0.30H" /AntisenseName="yndK" /AntisenseCor="-0.33555507319526101" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S652" CDS 1703603..1703968 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage/plasmid replication protein" /protein_id="NP_389664.1" /db_xref="EnsemblGenomes-Gn:BSU17810" /db_xref="EnsemblGenomes-Tr:CAB13665" /db_xref="GOA:O31814" /db_xref="SubtiList:BG13447" /db_xref="UniProtKB/Swiss-Prot:O31814" /translation="MNCFKILHRIKTGKEGFMVFYISLFLILWLAAGFAVGMKQVYVD QLFDKAVIERLEKEANDHGHADRMIKQRVLYIAAVTVSGFISVYYEMKTIPQRRNIRK IEKNIMKLNQAKKRRMKRK*" /label="yndK CDS" gene 1703603..1703968 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /label="yndK gene" downshifts 1703945 /Source="Nicolas_upshifts" /id="D970" /incds=0 /nref=166 /ntot=243 /MaxReadThrough="2.62352" /MaxDrop="5.68917" /score="15.340233" /energy="-10.4" /TU="NA" /idTUdmin="U1426" /TUdmin=2226 /isTUend="FALSE" /label="downshifts" misc_RNA complement(1703965..1704245) /gene="surA" /locus_tag="BSU_misc_RNA_72" /product="small untranslated RNA controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surA RNA" gene complement(1703965..1704245) /gene="surA" /locus_tag="BSU_misc_RNA_72" /label="surA gene" S_feature complement(1703974..1704105) /Source="Nicolas_S_feature" /locus_tag="new_1915001_1915132_c" /HighExp="B60, T2.0H, T1.30H, T1.0H, T2.30H, M9-stat, LoTm, S5, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.443, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S653" downshifts complement(1704017) /Source="Nicolas_upshifts" /id="D971" /incds=0 /nref=21 /ntot=129 /MaxReadThrough="4.91485" /MaxDrop="4.94426" /score="14.7738511" /energy="-10.4" /TU="U1429,U1431" /idTUdmin="U1429" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 1704065..1704074 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1704087..1704096) /Source="Nicolas_upshift_promotors" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1704088..1704107 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1704093 /Source="Nicolas_upshifts" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" S_feature 1704095..1704193 /Source="Nicolas_S_feature" /locus_tag="new_1915122_1915220" /HighExp="S8, S6, S7, BT, S5, G/S, B36, C30, Pyr, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52117199999999997" /TUshortSig="SigK" /TUshortPSig="0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S654" upshifts complement(1704105) /Source="Nicolas_upshifts" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1704107..1704237) /Source="Nicolas_S_feature" /locus_tag="new_1915134_1915264_c" /HighExp="T2.0H, T1.30H, M9-stat, T2.30H, T1.0H, B60, LoTm, T4.0H, T3.30H, T0.30H" /AntisenseName="yndL" /AntisenseCor="0.22331158442510801" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S655" CDS 1704194..1704952 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /EC_number="3.4.19.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26158264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage gamma-polyglutamate hydrolase" /protein_id="NP_389665.1" /db_xref="EnsemblGenomes-Gn:BSU17820" /db_xref="EnsemblGenomes-Tr:CAB13666" /db_xref="GOA:O31815" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13448" /db_xref="UniProtKB/Swiss-Prot:O31815" /translation="MKPAKVSLLRRLLHSLKHVDCNIAKRFPSTIKIVKLLMIFMVFT PISSIYAEDVYQNFEELKNNEDPSDYGVVTKETGSPVLVLAIHGGGIEGGTSEVAREL SKEYSMYLFEGLKSAGNSVLHITSTHFDEPRALKMTGNHEYVISLHGYAEEDQQIEVG GTDRVRAADLVEKLQHAGFPAVLLNMDHPHAGVSPNNIANKSKTGLSIQIEMSTGFRK SLFGIFSLKSRAVTQNERFYEFTEVMFRFLKNSY*" /label="pghL CDS" gene 1704194..1704952 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /label="pghL gene" upshifts 1704227 /Source="Nicolas_upshifts" /id="U1430" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.211788211788212" /xcortree=1323 /SigmaFactorBS="gttgatttggacttagaggcggagtagatgaaaccggccaaa gtatccctgctCcGccgtttgctccattccttgaagcatgttgattgtaacatagcca a" /listShort="yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1704243..1704262) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1704244) /Source="Nicolas_upshifts" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1704277..1704284) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1704767..1704978) /Source="Nicolas_S_feature" /locus_tag="new_1915794_1916005_c" /HighExp="S8, S5, S7, S6, S4, ferm, nit, BT, Pyr, G/S" /AntisenseName="yndL" /AntisenseCor="0.82198535504067005" /AntisenseRegPval="-66.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.515" /TUlongSig="NA" /TUlongPSig="NA" /label="S656" downshifts 1704931 /Source="Nicolas_upshifts" /id="D972" /incds=0 /nref=3 /ntot=23 /MaxReadThrough="4.17889" /MaxDrop="5.0493" /score="15.340233" /energy="-10.4" /TU="U1428,U1430" /idTUdmin="U1428" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" S_feature 1704976..1705595 /Source="Nicolas_S_feature" /locus_tag="new_1916003_1916622" /HighExp="S8, S6, S7, S5, C30, BT, G135, LBGstat, GM 150, M/G" /AntisenseName="yndM" /AntisenseCor="0.75549671487088998" /AntisenseRegPval="-50.2" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S657" CDS complement(1704979..1705518) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389666.1" /db_xref="EnsemblGenomes-Gn:BSU17830" /db_xref="EnsemblGenomes-Tr:CAB13667" /db_xref="GOA:O31816" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG13449" /db_xref="UniProtKB/Swiss-Prot:O31816" /translation="MTIMNGFELHYLSFVYAQEFSSKNNNLGGQMKHIIALASKIAFT LALLYVILDRVYHASFLSVMFIALFLGFVSYLSGDMLVLPRTNNITASLADFGLSFVI LWVFVLTQTRNDFSPFGAALLSAACLTVFEYFFHRYLLKNVLDENFRNELSARDNTLQ YQTEAADELFPETKEKHKE*" /label="yndM CDS" gene complement(1704979..1705518) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /label="yndM gene" promotor_-10 complement(1705519..1705533) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1705525) /Source="Nicolas_upshifts" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1705547..1705553) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1705573..1705582 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1705595..1705610 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1705597 /Source="Nicolas_upshifts" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" CDS 1705636..1706070 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /EC_number="2.5.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11244082, 16399398, 19763274, 23256780" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244082, 16399398, 19763274, 23256780; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="magnesium-dependent bacillithiol-transferase" /protein_id="NP_389667.1" /db_xref="EnsemblGenomes-Gn:BSU17840" /db_xref="EnsemblGenomes-Tr:CAB13668" /db_xref="GOA:O31817" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR022858" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13450" /db_xref="UniProtKB/Swiss-Prot:O31817" /translation="MEIKGINHLLFSVSHLDTSIDFYQKVFGAKLLVKGRTTAYFDMN GIWLALNEEPDIPRNDIKLSYTHIAFTIEDHEFEEMSAKLKRLHVNILPGRERDERDR KSIYFTDPDGHKFEFHTGTLQDRLRYYKQEKTHMHFYDETAF*" /label="fosB CDS" gene 1705636..1706070 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /label="fosB gene" CDS 1705928..1706275 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27144405" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513960.1" /translation="MNAIENQFILPTLTATNLNFIPEPFKTGFDITNKKKRICTFMMK RPFDSTTIFHIRLNLKKGVGGDFMFGEGFYPTCSTMPYLLNCTSDWVKVKLKYTLHYI LYEESELFYQMLN*" /label="yzzP CDS" gene 1705928..1706275 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /label="yzzP gene" S_feature 1706071..1706403 /Source="Nicolas_S_feature" /locus_tag="new_1917098_1917430" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T0.0H, T-1.10H, T2.30H, Salt, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.66836499999999999" /TUshortSig="SigWXY, Sig-, SigK" /TUshortPSig="1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S658" promotor_-35 1706362..1706371 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1706383..1706398 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1706405..1706583 /Source="Nicolas_S_feature" /locus_tag="new_1917432_1917610" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T-1.10H, T0.0H, T2.30H, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigWXY, Sig-, SigK" /TUshortPSig="0.99, 1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S659" upshifts 1706405 /Source="Nicolas_upshifts" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1706474..1706553 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /product="putative conserved small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="ncrF RNA" gene 1706474..1706553 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /label="ncrF gene" downshifts 1706540 /Source="Nicolas_upshifts" /id="D973" /incds=0 /nref=16 /ntot=188 /MaxReadThrough="2.99425" /MaxDrop="4.30173" /score="-1.31226475" /energy="-14.3" /TU="U1433" /idTUdmin="U1434" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(1706612..1707229) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the SOS regulon" /protein_id="NP_389668.1" /db_xref="EnsemblGenomes-Gn:BSU17850" /db_xref="EnsemblGenomes-Tr:CAB13669" /db_xref="GOA:P31080" /db_xref="InterPro:IPR006197" /db_xref="InterPro:IPR006199" /db_xref="InterPro:IPR006200" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR036286" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10678" /db_xref="UniProtKB/Swiss-Prot:P31080" /translation="MTKLSKRQLDILRFIKAEVKSKGYPPSVREIGEAVGLASSSTVH GHLARLETKGLIRRDPTKPRAIEILDEEVDIPQSQVVNVPVIGKVTAGSPITAVENIE EYFPLPDRMVPPDEHVFMLEIMGDSMIDAGILDKDYVIVKQQNTANNGEIVVAMTEDD EATVKRFYKEDTHIRLQPENPTMEPIILQNVSILGKVIGVFRTVH*" /label="lexA CDS" gene complement(1706612..1707229) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /label="lexA gene" downshifts complement(1706613) /Source="Nicolas_upshifts" /id="D974" /incds=0 /nref=186 /ntot=254 /MaxReadThrough="2.74616" /MaxDrop="7.90985" /score="8.16083322" /energy="-16.3" /TU="U1435" /idTUdmin="U1435" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1707253..1707272) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1707274) /Source="Nicolas_upshifts" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1707286..1707293) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1707309..1707316 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1707328 /Source="Nicolas_upshifts" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1707330..1707349 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1707379..1707696 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12581363, 16267290, 16549676, 20400548, 20807205, 23728628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12581363, 16267290, 16549676, 20400548, 20807205, 23728628; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="NP_389669.1" /db_xref="EnsemblGenomes-Gn:BSU17860" /db_xref="EnsemblGenomes-Tr:CAB13670" /db_xref="GOA:Q45056" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR022887" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11820" /db_xref="UniProtKB/Swiss-Prot:Q45056" /translation="MIMSKESIIFVGLFTVILSAVILMLSYTSSGQELNQYVKIEVQQ GDTLWSIADQVADTKKINKNDFIEWVADKNQLQTSDIQPGDELVIPLKKKHQDAYELA TVR*" /label="dinK CDS" gene 1707379..1707696 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /label="dinK gene" promotor_-10 complement(1707396..1707414) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1707399) /Source="Nicolas_upshifts" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1707428..1707435) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1707715..1708368 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /function="16.9: Replicate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12581363, 16267290, 17020588, 19060143, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase, resolvase" /protein_id="NP_389670.1" /db_xref="EnsemblGenomes-Gn:BSU17870" /db_xref="EnsemblGenomes-Tr:CAB13671" /db_xref="GOA:Q45057" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG11821" /db_xref="UniProtKB/Swiss-Prot:Q45057" /translation="MKALIYARVSTNKEQQETSLKRQEEELTAIAAENGMEVVKVISE KASGYEMDRDGVFELLDEIKNADIDVILVQDETRLGRGNAKIALLHCIYREGVKVYTT AHRGELELSEADSMVLEIVSIVEEYQRKIHNMKIRRGMKRAVKNGFKPQKNLKNQHGN SGKEKIEVPISEIVRLRANKLTFAEIAATLRGFGYDVSKATVHRRFQEYIENEETAE* " /label="dinL CDS" gene 1707715..1708368 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /label="dinL gene" promotor_-35 1708371..1708378 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-35" promotor_-10 1708392..1708411 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-10" upshifts 1708405 /Source="Nicolas_upshifts" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="upshifts" CDS 1708432..1708665 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12581363, 16267290, 18431750,19306341, 22333191, 22933559, 23099262" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389671.1" /db_xref="EnsemblGenomes-Gn:BSU17880" /db_xref="EnsemblGenomes-Tr:CAB13672" /db_xref="GOA:O31818" /db_xref="InterPro:IPR009242" /db_xref="PDB:2HEP" /db_xref="PDB:2JVD" /db_xref="PDB:3BHP" /db_xref="SubtiList:BG13466" /db_xref="UniProtKB/Swiss-Prot:O31818" /translation="MISNAKIARINELAAKAKAGVITEEEKAEQQKLRQEYLKGFRSS MKNTLKSVKIIDPEGNDVTPEKLKREQRNNKLH*" /label="ynzC CDS" gene 1708432..1708665 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /label="ynzC gene" S_feature 1708666..1708801 /Source="Nicolas_S_feature" /locus_tag="new_1919693_1919828" /HighExp="M40t90, M40t45, dia15, C90, Etha, H2O2, T5.0H, Salt, dia5, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S660" promotor_-35 1708769..1708776 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-35" promotor_-10 1708790..1708809 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-10" upshifts 1708803 /Source="Nicolas_upshifts" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="upshifts" CDS 1708834..1710837 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /EC_number="2.2.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696621, 12682299, 12882400, 27739585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696621, 12682299, 12882400, 27739585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transketolase" /protein_id="NP_389672.1" /db_xref="EnsemblGenomes-Gn:BSU17890" /db_xref="EnsemblGenomes-Tr:CAB13673" /db_xref="GOA:P45694" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005478" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033247" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11247" /db_xref="UniProtKB/Swiss-Prot:P45694" /translation="MDTIEKKSVATIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTK FMNVSPANPGWFNRDRFVLSAGHGSALLYSMLHLSGFDLSIEDLKGFRQWGSKTPGHP EFGHTAGVDATTGPLGQGIAMAVGMAIAERHLAETYNRDSFNVVDHYTYSICGDGDLM EGISSEAASLAGHLQLGRLIVLYDSNDISLDGDLDRSFSENVKQRFEAMNWEVLYVED GNNIEELTAAIEKARQNEKKPTLIEVKTTIGFGSPNRAGTSGVHGAPLGKEESKLTKE AYAWTYEEDFYVPSEVYEHFAVAVKESGEKKEQEWNAQFAKYKEVYPELAEQLELAIK GELPKDWDQEVPVYEKGSSLASRASSGEVLNGLAKKIPFFVGGSADLAGSNKTTIKNA GDFTAVDYSGKNFWFGVREFAMGAALNGMALHGGLRVFGGTFFVFSDYLRPAIRLAAL MGLPVTYVFTHDSIAVGEDGPTHEPVEQLASLRAMPNLSLIRPADGNETAAAWKLAVQ STDHPTALVLTRQNLPTIDQTSEEALAGVEKGAYVVSKSKNETPDALLIASGSEVGLA IEAQAELAKENIDVSVVSMPSMDRFEKQSDEYKNEVLPADVKKRLAIEMGSSFGWGKY TGLEGDVLGIDRFGASAPGETIINEYGFSVPNVVNRVKALINK*" /label="tktA CDS" gene 1708834..1710837 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /label="tktA gene" misc_feature complement(1709038..1709057) /Source="Nicolas_upshift_promotors" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1709055) /Source="Nicolas_upshifts" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1710827 /Source="Nicolas_upshifts" /id="D975" /incds=0 /nref=230 /ntot=257 /MaxReadThrough="4.5478" /MaxDrop="6.66676" /score="16.4587041" /energy="-10.6" /TU="U1439" /idTUdmin="U1436" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1710839..1711497) /Source="Nicolas_S_feature" /locus_tag="new_1921866_1922524_c" /HighExp="Lbstat, C30, Salt, BC, S7, LPhT, S8, M0t90, T-0.40H, Glucon" /AntisenseName="yneE" /AntisenseCor="4.3891878649396997E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.604, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S661" upshifts 1710937 /Source="Nicolas_upshifts" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="upshifts" misc_feature 1710938..1710957 /Source="Nicolas_upshift_promotors" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1710990..1711436 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /experiment="publication(s) with functional evidences, PMID:19682252, 25041308, 22720735, 27489185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682252, 25041308, 22720735, 27489185; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor controlling DNA replication" /protein_id="NP_389673.1" /db_xref="EnsemblGenomes-Gn:BSU17900" /db_xref="EnsemblGenomes-Tr:CAB13674" /db_xref="GOA:P45707" /db_xref="InterPro:IPR019683" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG11248" /db_xref="UniProtKB/Swiss-Prot:P45707" /translation="MERHYYTYLIKEEFANHYFGRESVMFELFQDYHWTSLEKQQYEM TEKQIQYITQPIPILHMHQRLKMNLNKTDYRQLDYIYRIALPKAKGHATFMMKEHMIE IVASGDYEAETIFFEVLRKVSPCFLAMDFNSKRYGWLNPVKERNFV*" /label="pcfA CDS" gene 1710990..1711436 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /label="pcfA gene" misc_feature 1711460..1711479 /Source="Nicolas_upshift_promotors" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1711468 /Source="Nicolas_upshifts" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1711479..1711496) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1711497) /Source="Nicolas_upshifts" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1711515..1711519) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1711522..1711740 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389674.1" /db_xref="EnsemblGenomes-Gn:BSU17910" /db_xref="EnsemblGenomes-Tr:CAB13675" /db_xref="GOA:P45708" /db_xref="InterPro:IPR005359" /db_xref="SubtiList:BG11249" /db_xref="UniProtKB/Swiss-Prot:P45708" /translation="MTLWVGILVGVVALLIGVALGFFIARKYMMSYLKKNPPINEQML RMMMMQMGMKPSQKKINQMMKAMNNQTK*" /label="yneF CDS" gene 1711522..1711740 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /label="yneF gene" downshifts 1711752 /Source="Nicolas_upshifts" /id="D976" /incds=0 /nref=243 /ntot=260 /MaxReadThrough="3.51446" /MaxDrop="7.54782" /score="0.133420982" /energy="-4.3" /TU="U1441,U1442" /idTUdmin="U1439" /TUdmin=287 /isTUend="FALSE" /label="downshifts" S_feature 1711797..1712096 /Source="Nicolas_S_feature" /locus_tag="new_1922824_1923123" /HighExp="S4, S3, S5, G180, S8, T5.0H, LoTm, G135, S6, S7" /AntisenseName="ynzD" /AntisenseCor="-0.33023056016157298" /AntisenseRegPval="-7.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S662" CDS complement(1711814..1711987) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11679073, 15187183, 17350627, 22303282, 23378509, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11679073, 15187183, 17350627, 22303282, 23378509, 27965289; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Spo0A-P phosphatase" /protein_id="NP_389675.1" /db_xref="EnsemblGenomes-Gn:BSU17920" /db_xref="EnsemblGenomes-Tr:CAB13676" /db_xref="GOA:O31819" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG13467" /db_xref="UniProtKB/Swiss-Prot:O31819" /translation="MIREHLLKEIEKKRAELLQIVMANGMTSHITIELSQELDHLLIQ YQKQRLRAVAGDE*" /label="spo0D CDS" gene complement(1711814..1711987) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /label="spo0D gene" downshifts complement(1711827) /Source="Nicolas_upshifts" /id="D977" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="4.0851" /MaxDrop="5.22565" /score="1.92055758" /energy="-4.3" /TU="U1444,U1446" /idTUdmin="U1444" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1712025..1712044) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1712032) /Source="Nicolas_upshifts" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1712058..1712065) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1712067..1712075 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1712087..1712106) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1712087..1712105 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1712098..1712206 /Source="Nicolas_S_feature" /locus_tag="new_1923125_1923233" /HighExp="T4.0H, T3.30H, T3.0H, S2, Lbstat, T5.0H, T2.30H, S4, T-1.40H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA, SigA" /TUshortPSig="0.999, 1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S663" upshifts 1712098 /Source="Nicolas_upshifts" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1712099) /Source="Nicolas_upshifts" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1712121..1712128) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1712207..1712914 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /function="16.10: Respire" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16771673, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16771673, 16850406, 19682263; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome c-type biogenesis protein CcdA; thiol-disulfide oxido-reductase" /protein_id="NP_389676.1" /db_xref="EnsemblGenomes-Gn:BSU17930" /db_xref="EnsemblGenomes-Tr:CAB13677" /db_xref="GOA:P45706" /db_xref="InterPro:IPR003834" /db_xref="SubtiList:BG11240" /db_xref="UniProtKB/Swiss-Prot:P45706" /translation="MGDVNYFLTFGAGFLSFISPCCLPLYPAFLSYITGVSMDDVKTE KLLLQKRSLFHTLCFLLGFSVIFIALGYGTSFIGSLFRDYHDAIRQIGALLIILFGFI TLGVFRPEAMMKERRIHFKHKPSGFLGSVLIGMAFAAGWTPCTGPILAAVITLAGTNP GSAVPYMMLYVLGFAVPFLLLSFFITKLKWIRKNQLFIMKAGGVLMIVIGVLLFFNWM SLIIILLSDLFGGFTGF*" /label="ccdA CDS" gene 1712207..1712914 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /label="ccdA gene" promotor_-35 1712934..1712941 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1712953..1712972 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1712961 /Source="Nicolas_upshifts" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1713003..1713365 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative response regulator (CheY homolog)" /protein_id="NP_389677.1" /db_xref="EnsemblGenomes-Gn:BSU17940" /db_xref="EnsemblGenomes-Tr:CAB13678" /db_xref="GOA:P45709" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11250" /db_xref="UniProtKB/Swiss-Prot:P45709" /translation="MTRVLVVDDAKFMRVKIREILEEANYIIAGEAADGEQAADLYKK LRPDLVTMDITMPVKNGIKALRDILTFDPKAKVIMCTAMRQQRIVTEAIELGAKDFIV KPFEETKVLEAVSRVMGH*" /label="yneI CDS" gene 1713003..1713365 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /label="yneI gene" promotor_-35 1713383..1713386 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1713401..1713420 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1713412 /Source="Nicolas_upshifts" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1713444..1713935 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389678.1" /db_xref="EnsemblGenomes-Gn:BSU17950" /db_xref="EnsemblGenomes-Tr:CAB13679" /db_xref="GOA:P45710" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR031306" /db_xref="SubtiList:BG11251" /db_xref="UniProtKB/Swiss-Prot:P45710" /translation="MISMMIIVSSIIAVLMAVAVMVVRIKSSDKPVSPKKIILPPIFM STGALMFLFPVFWVTGAEFLEAFTLGVIFSIFLIKTSKFEIKNNEIYMKRSKAFVFIL VGLLVIRIVMKSILSTSIDYGALSGMFWILAFGMIVPWRIAMYLSYRKLHNELQSSNI QMN*" /label="yneJ CDS" gene 1713444..1713935 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /label="yneJ gene" downshifts 1713931 /Source="Nicolas_upshifts" /id="D978" /incds=0 /nref=110 /ntot=273 /MaxReadThrough="1.09905" /MaxDrop="5.9692" /score="16.4219082" /energy="-9.7" /TU="NA" /idTUdmin="U1445" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(1713966..1714394) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DynA" /protein_id="NP_389679.1" /db_xref="EnsemblGenomes-Gn:BSU17960" /db_xref="EnsemblGenomes-Tr:CAB13680" /db_xref="InterPro:IPR020203" /db_xref="SubtiList:BG11252" /db_xref="UniProtKB/Swiss-Prot:P45711" /translation="MLEGWFLWFILFWVIMMVVLLSIGGFFMFRKFLKRLPKEDGRSE LDWQDYYIENSRHLWNDENKQFLDELTAPVPELFRDAAKAKIAGKIGELALKEKVAKI DQQLMIKGYILATPKRDHTFLKRHLRDKKIDLEPYQTLLK*" /label="yneK CDS" gene complement(1713966..1714394) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /label="yneK gene" downshifts complement(1713983) /Source="Nicolas_upshifts" /id="D979" /incds=0 /nref=188 /ntot=245 /MaxReadThrough="1.60911" /MaxDrop="5.09033" /score="10.710816" /energy="-9.7" /TU="NA" /idTUdmin="U1449" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1714412..1714431) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1714424) /Source="Nicolas_upshifts" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1714426..1714511) /Source="Nicolas_S_feature" /locus_tag="new_1925453_1925538_c" /HighExp="S8, S6, S7, LBGstat, C30, dia15, S0, Cold, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.958, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S664" promotor_-35 complement(1714445..1714452) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1714482..1714491 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1714501..1714610 /Source="Nicolas_S_feature" /locus_tag="new_1925528_1925637" /HighExp="S8, BT, B36, S7, G/S, Pyr, B60, S6, Glucon, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S665" upshifts 1714501 /Source="Nicolas_upshifts" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1714504..1714523 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1714506..1714525) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1714511) /Source="Nicolas_upshifts" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1714513..1714596) /Source="Nicolas_S_feature" /locus_tag="new_1925540_1925623_c" /HighExp="S8, S6, S7, C30, BT, S5, Pyr, Glucon, BC, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S666" promotor_-35 complement(1714540..1714543) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1714567 /Source="Nicolas_upshifts" /id="D980" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="3.76639" /MaxDrop="5.34013" /score="5.70696998" /energy="-12.7" /TU="U1450" /idTUdmin="U1450" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1714628..1715020) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9068633, 11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068633, 11150673; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389680.1" /db_xref="EnsemblGenomes-Gn:BSU17970" /db_xref="EnsemblGenomes-Tr:CAB13681" /db_xref="GOA:Q45058" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11822" /db_xref="UniProtKB/Swiss-Prot:Q45058" /translation="MWRNASMNHSKRNDANDFDSMDEWLRQFFEDPFAWYDETLPIDL YETSQQYIIEADLTFLQPTQVTVTLSGCEFILTVKSSGQTFEKQMMLPFYFNDKNIQV ECENQILTVAVNKETEDGSSFSLQFPLS*" /label="cotM CDS" gene complement(1714628..1715020) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /label="cotM gene" downshifts complement(1714641) /Source="Nicolas_upshifts" /id="D981" /incds=0 /nref=20 /ntot=92 /MaxReadThrough="4.44864" /MaxDrop="4.9615" /score="11.5991121" /energy="-12.7" /TU="U1454" /idTUdmin="U1456" /TUdmin=486 /isTUend="FALSE" /label="downshifts" promotor_-35 1714863..1714868 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-35" promotor_-10 1714884..1714902 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-10" upshifts 1714888 /Source="Nicolas_upshifts" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="upshifts" promotor_-35 1714998..1715002 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1715012..1715026 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1715027..1715046) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1715029 /Source="Nicolas_upshifts" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1715042) /Source="Nicolas_upshifts" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1715060..1715069) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1715101..1715247) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389681.1" /db_xref="EnsemblGenomes-Gn:BSU17980" /db_xref="EnsemblGenomes-Tr:CAB13682" /db_xref="GOA:P71032" /db_xref="InterPro:IPR012614" /db_xref="SubtiList:BG11921" /db_xref="UniProtKB/Swiss-Prot:P71032" /translation="MTNKNTSKDMHKNAPKGHNPGQPEPLSGSKKVKNRNHTRQKHNS SHDM*" /label="sspP CDS" gene complement(1715101..1715247) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /label="sspP gene" downshifts complement(1715122) /Source="Nicolas_upshifts" /id="D982" /incds=0 /nref=42 /ntot=61 /MaxReadThrough="1.80349" /MaxDrop="6.88836" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1456" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(1715279..1715425) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018, 10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018, 10806362; Product type s: structure" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389682.1" /db_xref="EnsemblGenomes-Gn:BSU17990" /db_xref="EnsemblGenomes-Tr:CAB13683" /db_xref="GOA:P71031" /db_xref="InterPro:IPR012613" /db_xref="SubtiList:BG11920" /db_xref="UniProtKB/Swiss-Prot:P71031" /translation="MVKRKANHVINGMNDAKSQGKGAGYIENDQLVLTEAERQNNKKR KTNQ*" /label="sspO CDS" gene complement(1715279..1715425) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /label="sspO gene" S_feature 1715425..1715558 /Source="Nicolas_S_feature" /locus_tag="new_1926452_1926585" /HighExp="S8, S7, S3, S6, LoTm, S4, S5, BT, Pyr, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S667" upshifts 1715425 /Source="Nicolas_upshifts" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1715436..1715438 /Source="Nicolas_upshift_promotors" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(1715441..1715452) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1715455) /Source="Nicolas_upshifts" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1715467..1715473) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1715548..1715555 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1715560..1715652 /Source="Nicolas_S_feature" /locus_tag="new_1926587_1926679" /HighExp="B60, M40t90, T0.0H, HiOs, T4.0H, T5.0H, T2.30H, M0t90, Sw, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S668" upshifts 1715560 /Source="Nicolas_upshifts" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1715570..1715589 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1715611) /Source="Nicolas_upshifts" /id="D983" /incds=0 /nref=1 /ntot=67 /MaxReadThrough="2.77282" /MaxDrop="4.02811" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1458" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1715653..1718382 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /EC_number="4.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate hydratase (bifunctional aconitase)" /protein_id="NP_389683.1" /db_xref="EnsemblGenomes-Gn:BSU18000" /db_xref="EnsemblGenomes-Tr:CAB13684" /db_xref="GOA:P09339" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR006249" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG10478" /db_xref="UniProtKB/Swiss-Prot:P09339" /translation="MANEQKTAAKDVFQARKTFTTNGKTYHYYSLKALEDSGIGKVSK LPYSIKVLLESVLRQVDGFVIKKEHVENLAKWGTAELKDIDVPFKPSRVILQDFTGVP AVVDLASLRKAMAAVGGDPDKINPEIPVDLVIDHSVQVDKAGTEDALAVNMDLEFERN AERYKFLSWAKKAFNNYQAVPPATGIVHQVNLEFLASVVHAIEEDGELVTYPDTLVGT DSHTTMINGIGVLGWGVGGIEAEAGMLGQPSYFPVPEVIGAKLVGKLPNGTTATDLAL KVTQVLREKGVVGKFVEFFGPGIAELPLADRATIANMAPEYGATCGFFPVDEEALNYL RLTGRDPEHIDVVEAYCRSNGLFYTPDAEDPQFTDVVEIDLSQIEANLSGPKRPQDLI PLSAMQETFKKQLVSPAGNQGFGLNAEEENKEIKFKLLNGEETVMKTGAIAIAAITSC TNTSNPYVLIGAGLVAKKAVELGLKVPNYVKTSLAPGSKVVTGYLVNSGLLPYMKELG FNLVGYGCTTCIGNSGPLSPEIEEAVAKNDLLITSVLSGNRNFEGRIHPLVKGNYLAS PPLVVAYALAGTVNINLKTDPIGVGKDGQNVYFNDIWPSMDEINALVKQTVTPELFRK EYETVFDDNKRWNEIETTDEALYKWDNDSTYIQNPPFFEEMSVEPGKVEPLKGLRVVG KFGDSVTTDHISPAGAIGKDTPAGKYLQEKGVSPRDFNSYGSRRGNHEVMMRGTFANI RIKNQIAPGTEGGFTTYWPTGEVTSIYDACMKYKEDKTGLVVLAGKDYGMGSSRDWAA KGTNLLGIRTVIAESFERIHRSNLVFMGVLPLQFKQGENADTLGLTGKEVIEVDVDET VRPRDLVTVRAINEDGNVTTFEAVVRFDSEVEIDYYRHGGILQMVLREKMKQS*" /label="citB CDS" gene 1715653..1718382 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /label="citB gene" misc_feature complement(1715673..1715677) /Source="Nicolas_upshift_promotors" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1715677) /Source="Nicolas_upshifts" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1718383..1718453 /Source="Nicolas_S_feature" /locus_tag="new_1929410_1929480" /HighExp="M9-stat, B60, M40t90, Glucon, M0t90, MG-0.2, Mal, T2.30H, MG-0.1, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S669" CDS 1718454..1718966 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15342593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane-bound proteins with a thioredoxin-like domain" /protein_id="NP_389684.1" /db_xref="EnsemblGenomes-Gn:BSU18010" /db_xref="EnsemblGenomes-Tr:CAB13685" /db_xref="GOA:O31820" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13451" /db_xref="UniProtKB/Swiss-Prot:O31820" /translation="MLKKWLAGILLIMLVGYTGWNLYQTYSKKEVGIQEGQQAPDFSL KTLSGEKSSLQDAKGKKVLLNFWATWCKPCRQEMPAMEKLQKEYADKLAVVAVNFTSA EKSEKQVRAFADTYDLTFPILIDKKGINADYNVMSYPTTYILDEKGVIQDIHVGTMTK KEMEQKLDLD*" /label="yneN CDS" gene 1718454..1718966 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /label="yneN gene" downshifts 1718923 /Source="Nicolas_upshifts" /id="D984" /incds=0 /nref=115 /ntot=218 /MaxReadThrough="3.76369" /MaxDrop="5.09954" /score="13.5401842" /energy="-6.9" /TU="U1457" /idTUdmin="U1457" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" promotor_-35 1718992..1718998 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1719011 /Source="Nicolas_upshifts" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1719013..1719024 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1719047..1719172 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097732.1" /db_xref="EnsemblGenomes-Gn:BSU18019" /db_xref="EnsemblGenomes-Tr:CAX52626" /db_xref="InterPro:IPR025004" /db_xref="UniProtKB/Swiss-Prot:C0H418" /translation="MKKMRKRSFHELVMENKKELMTNTEYLNQLEEKLEQRFKQK*" /label="ynzL CDS" gene 1719047..1719172 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /label="ynzL gene" downshifts complement(1719065) /Source="Nicolas_upshifts" /id="D985" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.12259" /MaxDrop="3.48183" /score="-0.0160782027" /energy="-13.9" /TU="NA" /idTUdmin="U1462" /TUdmin=1298 /isTUend="FALSE" /label="downshifts" promotor_-35 1719186..1719192 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1719207..1719218 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1719209 /Source="Nicolas_upshifts" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" CDS 1719237..1719383 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054579.2" /db_xref="EnsemblGenomes-Gn:BSU18020" /db_xref="EnsemblGenomes-Tr:CAE01455" /db_xref="GOA:Q7WY69" /db_xref="InterPro:IPR012612" /db_xref="SubtiList:BG14179" /db_xref="UniProtKB/Swiss-Prot:Q7WY69" /translation="MGNNKKNGQPQYAPSHLGTKPVKYKANKGEKMHDTSGQRPIIMQ TKGE*" /label="sspN CDS" gene 1719237..1719383 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /label="sspN gene" CDS 1719420..1719671 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (thioredoxin-like protein)" /protein_id="NP_389685.1" /db_xref="EnsemblGenomes-Gn:BSU18030" /db_xref="EnsemblGenomes-Tr:CAB13686" /db_xref="GOA:Q45060" /db_xref="InterPro:IPR017524" /db_xref="SubtiList:BG11806" /db_xref="UniProtKB/Swiss-Prot:Q45060" /translation="MTKNQNQYQQPNPDDRSDNVEKLQDMVQNTIENIEEAEASMEFA SGEDKQRIKEKNARREQSIEAFRNEIQDESAARQNGYRS*" /label="sspT CDS" gene 1719420..1719671 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /label="sspT gene" downshifts 1719649 /Source="Nicolas_upshifts" /id="D986" /incds=0 /nref=41 /ntot=49 /MaxReadThrough="2.07653" /MaxDrop="7.06685" /score="32.1193211" /energy="-7" /TU="NA" /idTUdmin="U1457" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1719692..1719697 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1719711..1719730 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1719715..1719806 /Source="Nicolas_S_feature" /locus_tag="new_1930742_1930833" /HighExp="Etha, dia5, dia15, Diami, H2O2, G180, Salt, G150, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S670" upshifts 1719715 /Source="Nicolas_upshifts" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1719807..1720172 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /EC_number="3.1.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11959124, 11994151, 16294310, 18338382; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA thioesterase" /protein_id="YP_054580.1" /db_xref="EnsemblGenomes-Gn:BSU18040" /db_xref="EnsemblGenomes-Tr:CAB13687" /db_xref="GOA:Q45061" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR006684" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11823" /db_xref="UniProtKB/Swiss-Prot:Q45061" /translation="MGIVYHANYLVWMEVGRTALIKDLGFLYSDMEKKGVLSPVVDIN ISYKKPLHYGETAVVHTWIEDYNGFKTVYGYHIYNPAGELSIKATSSHICVDKESFKP IQFRKAFPDWHTAYEKAKK*" /label="yneP CDS" gene 1719807..1720172 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /label="yneP gene" CDS 1720188..1720487 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389687.1" /db_xref="EnsemblGenomes-Gn:BSU18050" /db_xref="EnsemblGenomes-Tr:CAB13688" /db_xref="SubtiList:BG11824" /db_xref="UniProtKB/Swiss-Prot:Q45062" /translation="MAFGVKREELNRWKQAVKRGEIAFLTHYWLDDRFPEAKTVTKAG CADIDKLVQWGAAYGLKKEWIHKKSEFPHFDLLGETQKYILEQENLTDHLIRFHL*" /label="yneQ CDS" gene 1720188..1720487 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /label="yneQ gene" downshifts 1720463 /Source="Nicolas_upshifts" /id="D987" /incds=0 /nref=55 /ntot=217 /MaxReadThrough="3.04989" /MaxDrop="5.5978" /score="-4.41102273" /energy="-6" /TU="NA" /idTUdmin="U1461" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1720518..1720805) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 23176286" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389688.1" /db_xref="EnsemblGenomes-Gn:BSU18060" /db_xref="EnsemblGenomes-Tr:CAB13689" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR008326" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11825" /db_xref="UniProtKB/Swiss-Prot:Q45063" /translation="MNMTINEDALNWYKEELDLESGDQVRFFVRYGGCSNVQKGFSLG VAKDAPQEAGVTAEADGITFFIEESDLWYFDNHDLLVSYSEDADEPVFEYQ*" /label="yneR CDS" gene complement(1720518..1720805) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /label="yneR gene" downshifts complement(1720539) /Source="Nicolas_upshifts" /id="D988" /incds=0 /nref=216 /ntot=260 /MaxReadThrough="3.77766" /MaxDrop="7.20006" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" downshifts complement(1720605) /Source="Nicolas_upshifts" /id="D989" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.5674" /MaxDrop="3.11178" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1720835..1720854) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1720847) /Source="Nicolas_upshifts" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1720870..1720877) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1720893..1721474) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphate:glycerol-3-phosphate O-acyltransferase" /protein_id="NP_389689.1" /db_xref="EnsemblGenomes-Gn:BSU18070" /db_xref="EnsemblGenomes-Tr:CAB13690" /db_xref="GOA:Q45064" /db_xref="InterPro:IPR003811" /db_xref="SubtiList:BG11826" /db_xref="UniProtKB/Swiss-Prot:Q45064" /translation="MLIALLIILAYLIGSIPSGLIVGKLAKGIDIREHGSGNLGATNA FRTLGVKAGSVVIAGDILKGTLATALPFLMHVDIHPLLAGVFAVLGHVFPIFAKFKGG KAVATSGGVLLFYAPLLFITMVAVFFIFLYLTKFVSLSSMLTGIYTVIYSFFVHDTYL LIVVTLLTIFVIYRHRANIKRIINKTEPKVKWL*" /label="plsY CDS" gene complement(1720893..1721474) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /label="plsY gene" S_feature 1721475..1721605 /Source="Nicolas_S_feature" /locus_tag="new_1932502_1932632" /HighExp="C30, S8, S7, S5, S6, S4, BC, S3, T4.0H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S671" misc_feature complement(1721500..1721519) /Source="Nicolas_upshift_promotors" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1721517) /Source="Nicolas_upshifts" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1721590..1721593 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1721607 /Source="Nicolas_upshifts" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1721609..1721628 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1721644..1722051 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA-binding protein" /protein_id="NP_389690.1" /db_xref="EnsemblGenomes-Gn:BSU18080" /db_xref="EnsemblGenomes-Tr:CAB13691" /db_xref="GOA:Q45065" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11827" /db_xref="UniProtKB/Swiss-Prot:Q45065" /translation="MQNPSKAEIKEILQRSKRIAVVGLSDRPDRTSHMVSKAMQDAGY EIIPVNPTIDEALGVKAVSSLKEIDGPIDIVNVFRRSEQLPGVAEEFLETDAPVFWAQ QGLVNEEAYQMLKEKGRTVIMDLCIKVAHAVTK*" /label="yneT CDS" gene 1721644..1722051 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /label="yneT gene" downshifts 1722047 /Source="Nicolas_upshifts" /id="D990" /incds=0 /nref=63 /ntot=221 /MaxReadThrough="4.35976" /MaxDrop="5.49229" /score="-2.11194139" /energy="-6" /TU="U1464" /idTUdmin="U1461" /TUdmin=1584 /isTUend="FALSE" /label="downshifts" promotor_-35 1722113..1722116 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1722131..1722150 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1722135..1722449 /Source="Nicolas_S_feature" /locus_tag="new_1933162_1933476" /HighExp="H2O2, G150, G180, Etha, Oxctl, LBGexp, dia0, Lbexp, M40t45, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S672" upshifts 1722135 /Source="Nicolas_upshifts" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="upshifts" CDS 1722450..1724417 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8969507, 9539793, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8969507, 9539793, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit B of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389691.2" /db_xref="EnsemblGenomes-Gn:BSU18090" /db_xref="EnsemblGenomes-Tr:CAB13692" /db_xref="GOA:Q59192" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005740" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11804" /db_xref="UniProtKB/Swiss-Prot:Q59192" /translation="MARKQQFDYNEDAIQVLEGLEAVRKRPGMYIGSTDARGLHHLVY EIVDNSVDEVLAGHGDHIIVKIHKDNSISVQDRGRGMPTGMHKLGKPTPEVILTVLHA GGKFGQGGYKTSGGLHGVGASVVNALSEWLTVTIERDGFVYQQRFENGGKPVTSLEKI GKTKKTGTLTHFKPDPTMFSTTTYNFETLSERLRESAFLLKGLKIELIDERNDQREVF YYENGIEAFVAYLNEEKDVLSEVVSFEGEHHSIEVDFAFQFNDGYSENILSFVNNVRT KDGGTHESGAKTAMTRAFNEYARKVALLKEKDKNLEGTDIREGLSAIISVRIPEELLQ FEGQTKGKLGTSEARSAVDAIVSEQLAYFLEENRDTATLLVKKAIKASQAREAARKAR EEARSGKKRKKSEATLSGKLTPAGSRNPAKNELYLVEGDSAGGSAKQGRDRRFQAVLP LRGKVINTEKAKLADIFKNEEINTIIHAIGGGVGADFSIDDINYDKIIIMTDADTDGA HIQVLLLTFFYRYMKPLIEHGKVFIALPPLYKVSKGSGKKEIIEYAWSDEEMGDVLKK VGKGYTIQRYKGLGEMNADQLWETTMNPESRTLVRVKIDDAARVERRVTTLMGDKVEP RRKWIEKNVAFGLDEESNILENENLSVAEEV*" /label="parE CDS" gene 1722450..1724417 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /label="parE gene" CDS 1724421..1726841 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9539793, 12682299, 16267290, 16272394, 24440393" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9539793, 12682299, 16267290, 16272394, 24440393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit A of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389692.2" /db_xref="EnsemblGenomes-Gn:BSU18100" /db_xref="EnsemblGenomes-Tr:CAB13693" /db_xref="GOA:Q45066" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005741" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="SubtiList:BG11803" /db_xref="UniProtKB/Swiss-Prot:Q45066" /translation="MSQPELFHDLPLEEVIGDRFGRYSKYIIQDRALPDARDGLKPVQ RRILYAMHTDGNTFDKNFRKAAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNVLI EMHGNNGSIDGDPPAAMRYTEARLSPIASELLRDIDKNTVEFVPNFDDTSKEPVVLPA MFPNLLVNGSTGISAGYATDIPPHHLGEVIDAVIKRIQMPSCSVDELMEVIKGPDFPT GGIIQGVDGIRKAYETGKGKIIIRGKAEIETIRGGREQIVITEIPFEVNKANLVKKMD EFRIDKKVEGISEVRDETDRTGLRVVIELKKEADAKGILNFLYKNTDLQITYNFNMVA IHNRRPMLMSLPSILDAYIGHQKEVVTNRSVYELQKAKDRHHIVEGLMKALSILDEVI ATIRSSSDKRDAKNNLIAKYEFTEPQAEAIVSLQLYRLTNTDITALKEEAEELGKKIE ELESILSNDKKLLKVITNSLKALKKKYADTRRSVIEEKIEEIKINLEVMVASEDVYVT VTKDGYLKRTSQRSFAASNGQDFGMKDTDRMLHQFEMNTTDVLLLFTNKGSYIYCPVH QLPDIRWKDMGQHFSNLITIDRDETIVKAIPIKEFDPSAYLLFFTKNGMVKKTELTHY KAQRYSKALVALNLKGEDELIDVHVTNGESQIFMATHLGYGLWFGEDEVNVVGARAAG VKGINLKEDDFVVSGEILQQSDSIVLFTQRGAVKRMSLSEFEKTSRAKRGVVMLRELK KNPHRVVALFACGLEQRLMAETEKGDRKELQTKELRTNDRYSNGSFFFDEEESGKVTA VWRLHTEQ*" /label="parC CDS" gene 1724421..1726841 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /label="parC gene" downshifts 1726821 /Source="Nicolas_upshifts" /id="D991" /incds=0 /nref=227 /ntot=255 /MaxReadThrough="0.556700000000001" /MaxDrop="5.87714" /score="9.15080033" /energy="-14.6" /TU="NA" /idTUdmin="U1465" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1726849..1727038) /Source="Nicolas_S_feature" /locus_tag="new_1937876_1938065_c" /HighExp="LPhT, B60, Etha, B36, Gly, LoTm, Sw, BC, S8, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99806099999999998" /TUshortSig="SigA, SigA, SigK" /TUshortPSig="0.968, 0.994, 0.642" /TUlongSig="NA" /TUlongPSig="NA" /label="S673" CDS complement(1726888..1727064) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (C-terminus)" /db_xref="PSEUDO:SOX90559.1" /translation="MFNITRLCNENMRRLLNMLFILRMVILGLFSFTALNLFVWQGIE VIHAVTDLFTNHES*" /label="ynfCc CDS" gene complement(1726888..1727064) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /pseudo /label="ynfCc gene" downshifts complement(1726892) /Source="Nicolas_upshifts" /id="D992" /incds=0 /nref=153 /ntot=267 /MaxReadThrough="0.609599999999999" /MaxDrop="7.72532" /score="38.0779167" /energy="-14.6" /TU="NA" /idTUdmin="U1467" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(1727039..1727449) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU18110" /db_xref="EnsemblGenomes-Tr:CAB13694" /db_xref="GOA:Q45067" /db_xref="PSEUDO:CAB13694.1" /db_xref="SubtiList:BG11828" /db_xref="UniProtKB/Swiss-Prot:Q45067" /translation="MDWGIIIKIFSNIKGGGDHLKKVTILKASILFLAIASFHLFSIP HAFDIGHHYKAVADQQEMHEMKAGQNADDEKKSITGAFTLTALWAMAVLLLTAESKST GYSRRRQRKKSFILAKFYQSSYFGKLHVQHHPIM*" /label="ynfCn CDS" gene complement(1727039..1727449) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /pseudo /label="ynfCn gene" promotor_-10 complement(1727422..1727441) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1727425) /Source="Nicolas_upshifts" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1727456..1727463) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1727490..1727509) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1727491) /Source="Nicolas_upshifts" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1727524..1727531) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1727538..1727557) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1727549) /Source="Nicolas_upshifts" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1727571..1727580) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1727797..1727802 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1727815..1727834 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1727820 /Source="Nicolas_upshifts" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="upshifts" S_feature 1727833..1727897 /Source="Nicolas_S_feature" /locus_tag="new_1938860_1938924" /HighExp="Cold, G180, Oxctl, G135, LBGexp, G150, HPh, dia0, Lbexp, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S674" CDS 1727898..1729295 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8969507, 12823818, 15849754, 16850406, 22607086; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+/Na+:nitrogen-donor aminoacid symporter" /protein_id="NP_389694.1" /db_xref="EnsemblGenomes-Gn:BSU18120" /db_xref="EnsemblGenomes-Tr:CAB13695" /db_xref="GOA:Q45068" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG11798" /db_xref="UniProtKB/Swiss-Prot:Q45068" /translation="MESFFNSLINIPSDFIWKYLFYILIGLGLFFTIRFGFIQFRYFI EMFRIVGEKPEGNKGVSSMQAFFISAASRVGTGNLTGVALAIATGGPGAVFWMWVVAA VGMASSFVESTLAQLYKVRDGEDFRGGPAYYIQKGLGARWLGIVFAILITVSFGLIFN AVQTNTIAGALDGAFHVNKIVVAIVLAVLTAFIIFGGLKRVVAVSQLIVPVMAGIYIL IALFVVITNITAFPGVIATIVKNALGFEQVVGGGIGGIIVIGAQRGLFSNEAGMGSAP NAAATAHVSHPAKQGFIQTLGVFFDTFIICTSTAFIILLYSVTPKGDGIQVTQAALNH HIGGWAPTFIAVAMFLFAFSSVVGNYYYGETNIEFIKTSKTWLNIYRIAVIAMVVYGS LSGFQIVWDMADLFMGIMALINLIVIALLSNVAYKVYKDYAKQRKQGLDPVFKAKNIP GLKNAETWEDEKQEA*" /label="alsT CDS" gene 1727898..1729295 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /label="alsT gene" downshifts 1729284 /Source="Nicolas_upshifts" /id="D993" /incds=0 /nref=112 /ntot=203 /MaxReadThrough="3.44078" /MaxDrop="5.75319" /score="16.664707" /energy="-14.7" /TU="U1469" /idTUdmin="U1469" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" downshifts 1729329 /Source="Nicolas_upshifts" /id="D994" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.22962" /MaxDrop="5.03444" /score="16.664707" /energy="-14.7" /TU="NA" /idTUdmin="U1469" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(1729385..1730131) /Source="Nicolas_S_feature" /locus_tag="new_1940412_1941158_c" /HighExp="S6, S8, S7, S5, BT, C30, B36, S4, LoTm, B60" /AntisenseName="eglS" /AntisenseCor="0.42607634596628102" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S675" promotor_-35 1729508..1729515 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1729527 /Source="Nicolas_upshifts" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1729528..1729547 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1729598..1731097 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /EC_number="3.2.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3024130, 7704256, 7710279, 15139916, 26907762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3024130, 7704256, 7710279, 15139916, 26907762; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-1,4-beta-glucanase" /protein_id="NP_389695.2" /db_xref="EnsemblGenomes-Gn:BSU18130" /db_xref="EnsemblGenomes-Tr:CAB13696" /db_xref="GOA:P10475" /db_xref="InterPro:IPR001547" /db_xref="InterPro:IPR001956" /db_xref="InterPro:IPR008965" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018087" /db_xref="InterPro:IPR036966" /db_xref="PDB:2L8A" /db_xref="PDB:3PZT" /db_xref="PDB:3PZU" /db_xref="PDB:3PZV" /db_xref="SubtiList:BG10437" /db_xref="UniProtKB/Swiss-Prot:P10475" /translation="MKRSISIFITCLLITLLTMGGMIASPASAAGTKTPVAKNGQLSI KGTQLVNRDGKAVQLKGISSHGLQWYGEYVNKDSLKWLRDDWGITVFRAAMYTADGGY IDNPSVKNKVKEAVEAAKELGIYVIIDWHILNDGNPNQNKEKAKEFFKEMSSLYGNTP NVIYEIANEPNGDVNWKRDIKPYAEEVISVIRKNDPDNIIIVGTGTWSQDVNDAADDQ LKDANVMYALHFYAGTHGQFLRDKANYALSKGAPIFVTEWGTSDASGNGGVFLDQSRE WLKYLDSKTISWVNWNLSDKQESSSALKPGASKTGGWRLSDLSASGTFVRENILGTKD STKDIPETPSKDKPTQENGISVQYRAGDGSMNSNQIRPQLQIKNNGNTTVDLKDVTAR YWYKAKNKGQNFDCDYAQIGCGNVTHKFVTLHKPKQGADTYLELGFKNGTLAPGASTG NIQLRLHNDDWSNYAQSGDYSFFKSNTFKTTKKITLYDQGKLIWGTEPN*" /label="eglS CDS" gene 1729598..1731097 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /label="eglS gene" promotor_-10 complement(1730130..1730149) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1730153) /Source="Nicolas_upshifts" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1730163..1730172) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1731045 /Source="Nicolas_upshifts" /id="D995" /incds=0 /nref=1 /ntot=89 /MaxReadThrough="3.59763" /MaxDrop="3.67571" /score="6.04626297" /energy="-10.7" /TU="NA" /idTUdmin="U1470" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS 1731165..1731428 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389696.1" /db_xref="EnsemblGenomes-Gn:BSU18140" /db_xref="EnsemblGenomes-Tr:CAB13697" /db_xref="InterPro:IPR020302" /db_xref="SubtiList:BG11829" /db_xref="UniProtKB/Swiss-Prot:Q45069" /translation="MDEILKQYMVLYKKMSNMINGPDYPGKEKDIQHQKDQIEVYEKQ LQQGFSTDYDYDVFADSVIKCAYGDMTLEDLEAVYYGLTTPFF*" /label="ynfE CDS" gene 1731165..1731428 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /label="ynfE gene" downshifts complement(1731687) /Source="Nicolas_upshifts" /id="D996" /incds=0 /nref=4 /ntot=148 /MaxReadThrough="1.78569" /MaxDrop="4.04338" /score="32.2414244" /energy="-12.6" /TU="NA" /idTUdmin="U1472" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(1731687..1732955) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /EC_number="3.2.1.136" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17028274, 25355936, 26559526, 28330222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17028274, 25355936, 26559526, 28330222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-xylanase" /protein_id="NP_389697.1" /db_xref="EnsemblGenomes-Gn:BSU18150" /db_xref="EnsemblGenomes-Tr:CAB13698" /db_xref="GOA:Q45070" /db_xref="InterPro:IPR001139" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR033452" /db_xref="PDB:3GTN" /db_xref="PDB:3KL0" /db_xref="PDB:3KL3" /db_xref="PDB:3KL5" /db_xref="SubtiList:BG11830" /db_xref="UniProtKB/Swiss-Prot:Q45070" /translation="MIPRIKKTICVLLVCFTMLSVMLGPGATEVLAASDVTVNVSAEK QVIRGFGGMNHPAWAGDLTAAQRETAFGNGQNQLGFSILRIHVDENRNNWYKEVETAK SAVKHGAIVFASPWNPPSDMVETFNRNGDTSAKRLKYNKYAAYAQHLNDFVTFMKNNG VNLYAISVQNEPDYAHEWTWWTPQEILRFMRENAGSINARVIAPESFQYLKNLSDPIL NDPQALANMDILGTHLYGTQVSQFPYPLFKQKGAGKDLWMTEVYYPNSDTNSADRWPE ALDVSQHIHNAMVEGDFQAYVWWYIRRSYGPMKEDGTISKRGYNMAHFSKFVRPGYVR IDATKNPNANVYVSAYKGDNKVVIVAINKSNTGVNQNFVLQNGSASNVSRWITSSSSN LQPGTNLTVSGNHFWAHLPAQSVTTFVVNR*" /label="xynC CDS" gene complement(1731687..1732955) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /label="xynC gene" S_feature complement(1732956..1733085) /Source="Nicolas_S_feature" /locus_tag="new_1943983_1944112_c" /HighExp="Lbstat, BC, M0t90, LBGstat, Sw, T2.0H, M40t90, BI, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99419599999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S676" CDS complement(1733086..1734627) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1938968, 17426966, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938968, 17426966, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinoxylan arabinofuranohydrolase" /protein_id="NP_389698.1" /db_xref="EnsemblGenomes-Gn:BSU18160" /db_xref="EnsemblGenomes-Tr:CAB13699" /db_xref="GOA:Q45071" /db_xref="InterPro:IPR005084" /db_xref="InterPro:IPR006584" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR023296" /db_xref="PDB:3C7E" /db_xref="PDB:3C7F" /db_xref="PDB:3C7G" /db_xref="PDB:3C7H" /db_xref="PDB:3C7O" /db_xref="SubtiList:BG11807" /db_xref="UniProtKB/Swiss-Prot:Q45071" /translation="MRKKCSVCLWILVLLLSCLSGKSAYAATSTTIAKHIGNSNPLID HHLGADPVALTYNGRVYIYMSSDDYEYNSNGTIKDNSFANLNRVFVISSADMVNWTDH GAIPVAGANGANGGRGIAKWAGASWAPSIAVKKINGKDKFFLYFANSGGGIGVLTADS PIGPWTDPIGKPLVTPSTPGMSGVVWLFDPAVFVDDDGTGYLYAGGGVPGVSNPTQGQ WANPKTARVIKLGPDMTSVVGSASTIDAPFMFEDSGLHKYNGTYYYSYCINFGGTHPA DKPPGEIGYMTSSSPMGPFTYRGHFLKNPGAFFGGGGNNHHAVFNFKNEWYVVYHAQT VSSALFGAGKGYRSPHINKLVHNADGSIQEVAANYAGVTQISNLNPYNRVEAETFAWN GRILTEKSTAPGGPVNNQHVTSIQNGDWIAVGNADFGAGGARSFKANVASTLGGKIEV RLDSADGKLVGTLNVPSTGGAQTWREIETAVSGATGVHKVFFVFTGTGTGNLFNFDYW QFTQR*" /label="xynD CDS" gene complement(1733086..1734627) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /label="xynD gene" S_feature complement(1734628..1734949) /Source="Nicolas_S_feature" /locus_tag="new_1945655_1945976_c" /HighExp="M0t90, LBGstat, T1.30H, T2.30H, BC, M9-stat, T2.0H, T3.0H, T0.30H, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25588499999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S677" promotor_-10 complement(1734939..1734958) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1734950) /Source="Nicolas_upshifts" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1734973..1734976) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1735176..1735183 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1735196..1735215 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1735203 /Source="Nicolas_upshifts" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1735222..1735668 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein possibly involved in arabinogalactan metabolism" /protein_id="NP_389699.1" /db_xref="EnsemblGenomes-Gn:BSU18170" /db_xref="EnsemblGenomes-Tr:CAB13700" /db_xref="GOA:O31821" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG13452" /db_xref="UniProtKB/Swiss-Prot:O31821" /translation="MTATRIFYEGRFVTLKEKIKTLGRFCTVGVGNTLIDFGVFFLLT ACHVSYLPAQICSYTAGIVNSYVWNRNWTFCVKRKADGKEIVRFLMINIAASGITFLL LYLFQNCGCSLLVSKLAATIGGMMMNFIGNRIWVFGDSLKNIQDQE*" /label="yngA CDS" gene 1735222..1735668 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /label="yngA gene" CDS 1735675..1736568 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /EC_number="2.7.7.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8320212, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_389700.1" /db_xref="EnsemblGenomes-Gn:BSU18180" /db_xref="EnsemblGenomes-Tr:CAB13701" /db_xref="GOA:O31822" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13453" /db_xref="UniProtKB/Swiss-Prot:O31822" /translation="MRKKVRKAVIPAAGLGTRFLPATKAQPKEMLPIVDKPAIQYIVE EAAESGIEDILIITGRNKRSIEDHFDRSAELEFNLREKGKTETLKEMQQIADLANIHY IRQKEPLGLGHAVLCAEHFIGDEPFAVLLGDDIMVSETPALRQLMDVYDVYGTEVVGV QSVLPEDVSKYGIINTSGSQGHVYEVNDLVEKPSPEEAPSEIAVMGRYVLNSSIFSVL KTIGRGAGNEIQLTDALREVCRKEPIHARLLEGNRYDIGDKLGCFKASTEIGLMRPEM RSQLLAYLEDVIKRETKEMLR*" /label="yngB CDS" gene 1735675..1736568 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /label="yngB gene" misc_feature 1736185..1736204 /Source="Nicolas_upshift_promotors" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1736193 /Source="Nicolas_upshifts" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="upshifts" CDS 1736641..1737237 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein, phosphatase or phosphate isomerase" /protein_id="NP_389701.1" /db_xref="EnsemblGenomes-Gn:BSU18190" /db_xref="EnsemblGenomes-Tr:CAB13702" /db_xref="GOA:O31823" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13454" /db_xref="UniProtKB/Swiss-Prot:O31823" /translation="MGSLISEILTWLTNMGYAGIAIGLMIEIIPSEIVLAYGGYMVSE GTIGFIGAIIAGVIGGTIAQIFIYWIGRYGGRPFLDKYGKYLLIKKHHIDMSENWFQK YGAGVVFSARFIPVVRHAISIPAGIARMPFLKFVVLTVLAIIPWSILFVYLGIQLGSQ WDDVENIAGTYTTPIMILAVVVIALYFVIKKRTAIFKR*" /label="yngC CDS" gene 1736641..1737237 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /label="yngC gene" downshifts 1737227 /Source="Nicolas_upshifts" /id="D997" /incds=0 /nref=191 /ntot=259 /MaxReadThrough="1.94273" /MaxDrop="5.58345" /score="15.4353025" /energy="-15" /TU="NA" /idTUdmin="U1474" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1737286..1738485) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19553197, 22262096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19553197, 22262096; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoribonuclease (nanoRNase)" /protein_id="NP_389702.1" /db_xref="EnsemblGenomes-Gn:BSU18200" /db_xref="EnsemblGenomes-Tr:CAB13703" /db_xref="GOA:O31824" /db_xref="SubtiList:BG13455" /db_xref="UniProtKB/Swiss-Prot:O31824" /translation="MYHLYSHNDLDGVGCGIVAKLAFGKDVEIRYNSVNGLNAQVQYF LEKAKESNRQDALFITDLAVNEENEERLNEYVHAGGKVKLIDHHKTALHLNEHEWGFV QVEYDDGRLTSATSLLYGYLIENGFMKPTNALDQFTELVRQYDTWEWERYDQKQAKRL NDLFFLLSIDEFEAKMIQRLSTHDEFFFDDFEEKLLDLEDEKIERYLRRKKREMVQTF VHEHCVGIVHAESYHSELGNRLGKDNPHLDYIAILSMGSKRVSLRTIHDYIDVSEIAG RYGGGGHAKASGCSITDEVYELFVAEAFRIDPVRPDAFRNIYNLKGSANGSLYENRAQ MRFFLFPLDNEWNIQINGETQDETFAAFEEAEWFIKRNYAASLVRDEVFVAFLAENLK LANQHRK*" /label="nrnB CDS" gene complement(1737286..1738485) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /label="nrnB gene" S_feature complement(1738486..1738557) /Source="Nicolas_S_feature" /locus_tag="new_1949513_1949584_c" /HighExp="S5, S7, S4, S8, S6, ferm, nit, LBGstat, T5.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S678" promotor_-10 complement(1738545..1738556) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1738557) /Source="Nicolas_upshifts" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1738571..1738577) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1738655..1740190) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /EC_number="6.4.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylcrotonoyl-CoA carboxylase subunit (leucinedegradation)" /protein_id="NP_389703.2" /db_xref="EnsemblGenomes-Gn:BSU18210" /db_xref="EnsemblGenomes-Tr:CAB13704" /db_xref="GOA:O31825" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13456" /db_xref="UniProtKB/Swiss-Prot:O31825" /translation="MLMDYEKERTERAERIRKGGAEKYHQSNREKGKLFVRERLSLLF DDDIELEDAFFAECMSDGLPADGVVTAIGKIGGQTVCVMANDSTVKAGSWGAKTVEKI IRIQEIAEKLNCPLIYLVDSAGARITDQINVFPGRRGAGRIFYNQVKLSGRIPQICLL FGPSAAGGAYIPAFCDIVVMVDGNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSIS GCGDILAETEEEAIQLVRAYLSYFPANFQEKAPIHEKRPPKHFETPLADVIPQNQNAP FDMHELIERVIDEDSFFEIKALFAPELLTGLARIHGQPVGIVANQPKVKGGVLFHDSA DKAAKFITLCDAFHIPLLFLADIPGFMIGTKVEQAGIIRHGAKMISAMSEATVPKLSV IVRKAYGAGLYAMAGPAFEPDCCLALPTAQIAVMGPEAAVNAVYAKKIAELPEEERAA FISSKREEYKEDINIYRLASEMIIDAVIPANSLRDELAKRLKAYMTKEMTFTNRKHPV YPV*" /label="ldeE CDS" gene complement(1738655..1740190) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /label="ldeE gene" downshifts complement(1738667) /Source="Nicolas_upshifts" /id="D998" /incds=0 /nref=18 /ntot=38 /MaxReadThrough="1.74923" /MaxDrop="5.31437" /score="-1.4478995" /energy="-11.8" /TU="NA" /idTUdmin="U1477" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1740201..1740983) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /EC_number="4.2.1.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglutaconyl-CoA hydratase (leucine degradation)" /protein_id="NP_389704.1" /db_xref="EnsemblGenomes-Gn:BSU18220" /db_xref="EnsemblGenomes-Tr:CAB13705" /db_xref="GOA:O34893" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG13457" /db_xref="UniProtKB/Swiss-Prot:O34893" /translation="MGDSILFTVKNEHMALITLNRPQAANALSAEMLRNLQMIIQEIE FNSNIRCVILTGTGEKAFCAGADLKERIKLKEDQVLESVSLIQRTAALLDALPQPVIA AINGSALGGGLELALACDLRIATEAAVLGLPETGLAIIPGAGGTQRLPRLIGRGKAKE FIYTGRRVTAHEAKEIGLVEHVTAPCDLMPKAEELAAAISANGPIAVRQAKFAINKGL ETDLATGLAIEQKAYEQTIPTKDRREGLQAFQEKRRAVYKGI*" /label="ldeF CDS" gene complement(1740201..1740983) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /label="ldeF gene" CDS complement(1741004..1741903) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /EC_number="4.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16330546, 19935659, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxymethylglutaryl-CoA lyase (leucine degradation)" /protein_id="NP_389705.1" /db_xref="EnsemblGenomes-Gn:BSU18230" /db_xref="EnsemblGenomes-Tr:CAB13706" /db_xref="GOA:O34873" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR013785" /db_xref="PDB:1YDO" /db_xref="SubtiList:BG13458" /db_xref="UniProtKB/Swiss-Prot:O34873" /translation="MPYPKKVTIKEVGPRDGLQNEPVWIATEDKITWINQLSRTGLSY IEITSFVHPKWIPALRDAIDVAKGIDREKGVTYAALVPNQRGLENALEGGINEACVFM SASETHNRKNINKSTSESLHILKQVNNDAQKANLTTRAYLSTVFGCPYEKDVPIEQVI RLSEALFEFGISELSLGDTIGAANPAQVETVLEALLARFPANQIALHFHDTRGTALAN MVTALQMGITVFDGSAGGLGGCPYAPGSSGNAATEDIVYMLEQMDIKTNVKLEKLLSA AKWIEEKMGKPLPSRNLQVFKSS*" /label="ldeG CDS" gene complement(1741004..1741903) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /label="ldeG gene" CDS complement(1741918..1742139) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type c: carrier" /codon_start=1 /transl_table=11 /product="methylcrotonyl-CoA carboxylase; biotinylated subunit (leucine degradation)" /protein_id="YP_003097733.1" /db_xref="EnsemblGenomes-Gn:BSU18239" /db_xref="EnsemblGenomes-Tr:CAX52627" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR011053" /db_xref="PDB:1Z6H" /db_xref="PDB:1Z7T" /db_xref="PDB:2B8F" /db_xref="PDB:2B8G" /db_xref="UniProtKB/Swiss-Prot:C0H419" /translation="MTVSIQMAGNLWKVHVKAGDQIEKGQEVAILESMKMEIPIVADR SGIVKEVKKKEGDFVNEGDVLLELSNSTQ*" /label="lgeHB CDS" gene complement(1741918..1742139) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /label="lgeHB gene" CDS complement(1742154..1743488) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /EC_number="6.4.1.4" /EC_number="6.3.4.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7915138, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin carboxylase for subunit LdeHB of methylcrotonyl-CoA carboxylase" /protein_id="NP_389706.1" /db_xref="EnsemblGenomes-Gn:BSU18240" /db_xref="EnsemblGenomes-Tr:CAB13707" /db_xref="GOA:O34544" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG13459" /db_xref="UniProtKB/Swiss-Prot:O34544" /translation="MFTKVLIANRGEIAMRIIRTCSRLGIKTVAVYSEADKDAPHTKA ATEAYLIGESRVSESYLNIERIIKTAKKAKADAIHPGYGLLSENSRFAERCKQENIVF IGPSPDIIAKMGSKIEARKAMEAAGVPVVPGVSESLGDIEAACRTASQIGYPVMLKAS AGGGGIGMQRVENEEALKKAYEGNKKRAADFFGDGSMYIEKVIEHARHIEVQLLADQH GHTVHLFERDCSVQRRHQKVIEEAPSPFVDDELRMKIGQTAVKAAKAIGYTNAGTIEF IVDQKQNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLRIAAGHTLTFSQKDIQRNGHA IEVRIYAEDPKTFFPSPGTITAFSLPDQKGVRHECAVAKDSTVTPFYDPMIAKMIVKG QTRTEAIEKLETALRDYRVEGIKTNLPLLIQAAATKAFKEGDVTTDFLKQHL*" /label="ldeHA CDS" gene complement(1742154..1743488) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /label="ldeHA gene" CDS complement(1743498..1745147) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /EC_number="6.2.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12535077, 15213221, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl-CoA synthetase" /protein_id="NP_389707.1" /db_xref="EnsemblGenomes-Gn:BSU18250" /db_xref="EnsemblGenomes-Tr:CAB13708" /db_xref="GOA:O31826" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13460" /db_xref="UniProtKB/Swiss-Prot:O31826" /translation="MAELIHSTIGRLLEQTADAYPDRDAVVYPDRNIRYTYAQFDSLC RQTAKGLMRMGIGKGDHVAIWASNISEWLAVQFATAKIGAVLVTVNTNYQAHELDYLL KQSDAAALIIMDSYRGTSYPDIVNSLIPELQEAKPGQLKSERYPFLKTLIYIGNKRLS GMYHWDDTEILAKTVTDAELEERMNSLDKDNVINMQYTSGTTGFPKGVMLTHFNVINN AANIAECMALTSQDRMCIPVPFFHCFGCVLGVLACVSVGAAMIPVQEFDPVTVLKTVE KEKCTVLHGVPTMFIAELHHPDFDAYDLSTLRTGIMAGSPCPSEVMKAVIERMGMKDI TIAYGQTEASPVITQTRANDSFIRRVETTGRALPHTEVKIVEPGTCQEVQRGMQGELC TRGYHVMKGYYKDKDATRKAINHDGWLFTGDLAVMDEDGYCRITGRLKDMLIRGGENI YPREIEEFLYQHPAVLDVQVVGVPDAKFGEEAAAWIKLKDGKSVSPDELKAYCKGKIA RHKIPRYVIFTDDYPMTASGKIQKYKLREKTIEMFNLSSSQ*" /label="ldeI CDS" gene complement(1743498..1745147) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /label="ldeI gene" promotor_no_box 1743547..1743647 /Source="Nicolas_upshift_promotors" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1743607 /Source="Nicolas_upshifts" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1745191..1746333) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /EC_number="1.3.8.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8655474, 17085570, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isovaleryl-CoA dehydrogenase (leucine degradation)" /protein_id="NP_389708.1" /db_xref="EnsemblGenomes-Gn:BSU18260" /db_xref="EnsemblGenomes-Tr:CAB13709" /db_xref="GOA:O34421" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG13461" /db_xref="UniProtKB/Swiss-Prot:O34421" /translation="MNFELTKEQQMVREMVKDFAKKEIAPHAEHVDQTGEFPMQTFKK MGELGLMGIPFPEEYGGSGGDTISYALAVEEVGKACGSTGLSYAAAVSLGASPLYYFG TEEQKQTHLTPLASGTALGSFGLTEPNAGSDAGGTQTKAISNGDEYVINGEKCWITNA SYARTVIVTAVTGKNKDGKNIISALIVPTDTPGLTITSPYDKMGVRGSNTAEILLEDV RVPAANLLGDPTKGFKQFLYTLDGGRISIAALAVGIAQAALDASLAYAKERKQFGQPI SSFQAIQFKLADMAMEIDLARQMVLKAAWLKDHNRPFTKEAAYAKLFASEMATRACNQ AIQIHGGSGYMKEYGVERMLRDAKLMEIGEGTSEIQRLVIARQLLK*" /label="ldeJ CDS" gene complement(1745191..1746333) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /label="ldeJ gene" promotor_-10 complement(1746352..1746370) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1746369) /Source="Nicolas_upshifts" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1746386..1746391) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1746424..1746729) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389709.1" /db_xref="EnsemblGenomes-Gn:BSU18270" /db_xref="EnsemblGenomes-Tr:CAB13710" /db_xref="GOA:O34356" /db_xref="InterPro:IPR020509" /db_xref="SubtiList:BG13468" /db_xref="UniProtKB/Swiss-Prot:O34356" /translation="MLTDPAEEAFLPNFLLLGAGTALVLCLVFFLYQKLDQSQFAVIK LGIWGSAVGLLMDTISLWNLPLIFPALSKGQVIAFTIWMVCAYCMYLLIPLILSHKK* " /label="ynzE CDS" gene complement(1746424..1746729) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /label="ynzE gene" CDS complement(1746719..1746892) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513961.1" /translation="MNMEAVFGHLPLLESEKLVLNKNKIEEKHVQDVFYVFISSLVRC HIIFCAVRRCCVD*" /label="conserved protein of unknown function CDS" gene complement(1746719..1746892) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /label="gene" CDS complement(1747000..1748532) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative exported glycoside hydrolase" /protein_id="NP_389710.1" /db_xref="EnsemblGenomes-Gn:BSU18280" /db_xref="EnsemblGenomes-Tr:CAB13711" /db_xref="InterPro:IPR003790" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG13462" /db_xref="UniProtKB/Swiss-Prot:O35015" /translation="MKVCQKSIVRFLVSLIIGTFVISVPFMANAQSDRELRAVWIASV LNIDWPSKKGLSVKEQKQEYIKLLDDVQKMGMNAVIVQIKPTADAFYPSAYGPWSEYL TGVQGKDPGYDPLAFMIEETHKRNLEFHAWFNPYRITMNHTDLNKLSEDHPARKHPDW VAAYGNQLYYHPGIPEARDFIVKGIEEVVKHYDIDAVHMDDYFYPYKIAGQEFPDQAQ YEQYGKDAFSNIDDWRRDNVNQLVKQINQTIKAAKPYVKFGISPFGVWRNAADDPTGS NTKAGVRNYDDLYADTRHWIQEGDIDYIAPQIYWSIGFNAAAYDVLADWWSNEVKNRP VHLYIGQAAYKINNNFDPPWSDPEEYVRQITLNRQLELVKGSMHFSLKDLNKNPLGIK DSLSTDLYSKPALVPQMPWLDNTAPKKPKLTKVTEDKNGNLLQIKDHPSNQKTKETAY YAIYRAEGKKQRTLLATQRKTHEQQTFLDNTADPNKKYTYYVTSADRLHNESKASKRT TK*" /label="yngK CDS" gene complement(1747000..1748532) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /label="yngK gene" downshifts complement(1747011) /Source="Nicolas_upshifts" /id="D999" /incds=0 /nref=7 /ntot=27 /MaxReadThrough="2.27934" /MaxDrop="4.41371" /score="9.43133612" /energy="-8" /TU="NA" /idTUdmin="U1478" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1748567..1748586) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1748567) /Source="Nicolas_upshifts" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1748599..1748608) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1748668..1749060) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28163698; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389711.1" /db_xref="EnsemblGenomes-Gn:BSU18290" /db_xref="EnsemblGenomes-Tr:CAB13712" /db_xref="GOA:O34506" /db_xref="InterPro:IPR010773" /db_xref="SubtiList:BG13463" /db_xref="UniProtKB/Swiss-Prot:O34506" /translation="MDRLSFLTFIMLILASYRLTHLIVFDKITEFIRKPFMKKKRIVD QNGHVDEKSVPASNFGYMLNCYWCAGVWCAILIGLGYLFLPRIAIPLIFILAIAGAQA ILETAVGVGVKLIDVLKSLQTMMNDKKS*" /label="yngL CDS" gene complement(1748668..1749060) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /label="yngL gene" downshifts complement(1748699) /Source="Nicolas_upshifts" /id="D1000" /incds=0 /nref=2 /ntot=18 /MaxReadThrough="0.581539999999999" /MaxDrop="2.96298" /score="5.25915686" /energy="-11.4" /TU="NA" /idTUdmin="U1479" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1749088..1749099) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1749095) /Source="Nicolas_upshifts" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1749113..1749119) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(1749167,1749174) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs10" N_region 1749168..1749173 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs10" S_feature complement(<1749174..1749279) /Source="Nicolas_S_feature" /locus_tag="new_1997958_1998066_c" /HighExp="T1.30H, T1.0H, T0.30H, S1, M0t90, T2.30H, LPhT, C90, LoTm, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S679" promotor_-10 complement(1749264..1749283) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1749279) /Source="Nicolas_upshifts" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1749297..1749304) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1749553..1751028) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /EC_number="3.4.16.4" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733705, 9864321, 11160090, 14731276, 17582436, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 9864321, 11160090, 14731276, 17582436, 19758330; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase" /protein_id="NP_389717.1" /db_xref="EnsemblGenomes-Gn:BSU18350" /db_xref="EnsemblGenomes-Tr:CAB13718" /db_xref="GOA:P39844" /db_xref="InterPro:IPR000667" /db_xref="InterPro:IPR012338" /db_xref="PDB:1W5D" /db_xref="PDB:2J9P" /db_xref="SubtiList:BG10969" /db_xref="UniProtKB/Swiss-Prot:P39844" /translation="MKKSIKLYVAVLLLFVVASVPYMHQAALAAEKQDALSGQIDKIL ADHPALEGAMAGITVRSAETGAVLYEHSGDTRMRPASSLKLLTAAAALSVLGENYSFT TEVRTDGTLKGKKLNGNLYLKGKGDPTLLPSDFDKMAEILKHSGVKVIKGNLIGDDTW HDDMRLSPDMPWSDEYTYYGAPISALTASPNEDYDAGTVIVEVTPNQKEGEEPAVSVS PKTDYITIKNDAKTTAAGSEKDLTIEREHGTNTITIEGSVPVDANKTKEWISVWEPAG YALDLFKQSLKKQGITVKGDIKTGEAPSSSDVLLSHRSMPLSKLFVPFMKLSNNGHAE VLVKEMGKVKKGEGSWEKGLEVLNSTLPEFGVDSKSLVLRDGSGISHIDAVSSDQLSQ LLYDIQDQSWFSAYLNSLPVAGNPDRMVGGTLRNRMKGTPAQGKVRAKTGSLSTVSSL SGYAETKSGKKLVFSILLNGLIDEEDGKDIEDQIAVILANQ*" /label="dacC CDS" gene complement(1749553..1751028) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /label="dacC gene" downshifts complement(1749565) /Source="Nicolas_upshifts" /id="D1003" /incds=0 /nref=126 /ntot=224 /MaxReadThrough="1.56173" /MaxDrop="5.81468" /score="20.5621533" /energy="-10.2" /TU="NA" /idTUdmin="U1484" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" CDS complement(1751062..1752039) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /EC_number="5.1.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9733705, 12753898, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 12753898, 19758330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldose 1-epimerase" /protein_id="NP_389718.1" /db_xref="EnsemblGenomes-Gn:BSU18360" /db_xref="EnsemblGenomes-Tr:CAB13719" /db_xref="GOA:P39840" /db_xref="InterPro:IPR008183" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR014718" /db_xref="PDB:3MWX" /db_xref="PDB:4BZE" /db_xref="PDB:4BZF" /db_xref="PDB:4BZG" /db_xref="PDB:4BZH" /db_xref="SubtiList:BG10253" /db_xref="UniProtKB/Swiss-Prot:P39840" /translation="MANFIEKITYLGTPAIKAGNEHLEMIVVPEWGSNVISLVDKTTN VQLLREPETAESFHDTPTLYGIPILFPPNRISDGTFSFRGRTYHFDINEKDKHNHLHG FLYHEKWNVVTTKQTDEGVIVETEIDLSELPHVQKQFPHHAVVRMTYTIKENTLFKHA TVMNKGKEAFPWGIGYHTTFIFPAESSLFSLTADQQWELDERLLPTGKLMDVPYKEAL HEGMDLRHKQLDDVFLSSYQKRGGENQAVIYHQHAHISIIYKADEQFKHWVVYNADGK QGYLCPEPYTWVTNAVNLDLPSSLTGLQVLEPGEETTAKSSITIELNHQ*" /label="galM CDS" gene complement(1751062..1752039) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /label="galM gene" promotor_-10 complement(1752068..1752086) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1752080) /Source="Nicolas_upshifts" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1752098..1752106) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1752173..1753564) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven efflux transporter" /protein_id="NP_389719.2" /db_xref="EnsemblGenomes-Gn:BSU18370" /db_xref="EnsemblGenomes-Tr:CAB13720" /db_xref="GOA:O34474" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13548" /db_xref="UniProtKB/Swiss-Prot:O34474" /translation="METSQEPLVTQKKSKPSVWRSMSLFLVPLLLSNVLQSVGQLVGM MAVGRWLGVDAVAAVSSFFPLFFLLISFTIGIGSGSSILIGQAYGAKNEERLKAVVGT TLTFTFLLGVVLAVIGSIFTLDILRLMGTPENVIHVSANYARILFYAMPFMFLYFAYT TFLRGTGDSKTPFYTLIVSTVINIALLPVLILGMFGFPKLGIYGSAYATVISTIATFL VLMVYLRKRKHPLQFDKTVRRYLKMDKELLVLLLRLGVPASINMILVSLSEIAVISFV NHYGSNATAAYGVVNQVASYVQMPAVSLGIAVSIFAAQSIGANEFDRLKQVIRVGIWL NYIIGGVLIILIYVFSHQILSLFLTEQETLYIAHRLLMITLWSYLLFGNAQIISATMR ASGTVLWPTVISIFAIWGVEVPVAFVLSHYTKLEILGVWVGYPAAFAVSLLLIYGYYQ FVWKKKQITRLIQ*" /label="yoeA CDS" gene complement(1752173..1753564) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /label="yoeA gene" downshifts complement(1752187) /Source="Nicolas_upshifts" /id="D1004" /incds=0 /nref=74 /ntot=213 /MaxReadThrough="2.12119" /MaxDrop="5.14152" /score="31.8413544" /energy="-12.3" /TU="NA" /idTUdmin="U1486" /TUdmin=2 /isTUend="TRUE" /label="downshifts" downshifts 1752333 /Source="Nicolas_upshifts" /id="D1005" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="1.76262" /MaxDrop="3.63403" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1485" /TUdmin="-1452" /isTUend="FALSE" /label="downshifts" promotor_-35 1753354..1753360 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-35" promotor_-10 1753374..1753392 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-10" S_feature 1753385..1753718 /Source="Nicolas_S_feature" /locus_tag="new_2002172_2002505" /HighExp="M9-stat, Etha, Gly, S8, Sw, S7, B60, S6, Salt, C30" /AntisenseName="yoeA" /AntisenseCor="9.0133358617756607E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S680" upshifts 1753385 /Source="Nicolas_upshifts" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="upshifts" S_feature complement(1753565..1753669) /Source="Nicolas_S_feature" /locus_tag="new_2002352_2002456_c" /HighExp="S8, LBGstat, Etha, Cold, S7, T-1.40H, S2, C90, nit, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.456" /TUlongSig="NA" /TUlongPSig="NA" /label="S681" promotor_no_box complement(1753629..1753729) /Source="Nicolas_upshift_promotors" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1753669) /Source="Nicolas_upshifts" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1753691..1753696 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1753712..1753730 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1753720 /Source="Nicolas_upshifts" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1753778..1753785 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1753798..1753817 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1753801 /Source="Nicolas_upshifts" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="upshifts" CDS 1753850..1754395 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17483219, 17581128, 18761694, 22720735, 23091053" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483219, 17581128, 18761694, 22720735, 23091053; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of DL-endopeptidases involved in cell-separation" /protein_id="NP_389720.2" /db_xref="EnsemblGenomes-Gn:BSU18380" /db_xref="EnsemblGenomes-Tr:CAB13721" /db_xref="InterPro:IPR031841" /db_xref="PDB:2RSX" /db_xref="SubtiList:BG13549" /db_xref="UniProtKB/Swiss-Prot:O34841" /translation="MKKCLLFLTTIALILSLSTNAFAKNTSGDLSQKQALQLALSARE HFWNTMSGHNPKVKKAVCPSGTFEYQNLQYVYMCSDLGTKAKAVNYLTPIFTKTAIEK GFKDYHFTVSKGKLAVPIGDGDNLLNWKKSTAKLISKKGSTITYEFTVPTLDGSPSAK RKVTFVKENKKWKVNQFDAVI*" /label="iseA CDS" gene 1753850..1754395 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /label="iseA gene" downshifts 1754379 /Source="Nicolas_upshifts" /id="D1006" /incds=0 /nref=164 /ntot=264 /MaxReadThrough="4.38689" /MaxDrop="8.27665" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1487" /TUdmin=0 /isTUend="TRUE" /label="downshifts" tRNA complement(1754489..1754561) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Arg1 tRNA" gene complement(1754489..1754561) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /label="trnSL-Arg1 gene" downshifts complement(1754587) /Source="Nicolas_upshifts" /id="D1007" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="1.99821" /MaxDrop="3.03097" /score="3.94141467" /energy="-15.1" /TU="NA" /idTUdmin="U1489" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1754614..1755159) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacteriophage integrase" /protein_id="NP_389721.2" /db_xref="EnsemblGenomes-Gn:BSU18390" /db_xref="EnsemblGenomes-Tr:CAB13722" /db_xref="GOA:O35009" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR013762" /db_xref="SubtiList:BG13550" /db_xref="UniProtKB/Swiss-Prot:O35009" /translation="MHIVQPIRSLEKIQEVKQYLLNKNKRDYFLFIFGINSALRISDI LPLQVKDVQNKDHLWATESKTKKKRKILILESLKQEIYEYTKDMKENEYLFKSVRTRK PISRIQAYRILREAAAACGLEEIGTHTLRKTFGYHFYQRTKDIAELQRILNHSSPSIT MRYIGIDEDTTRAAYKVFGGL*" /label="yoeC CDS" gene complement(1754614..1755159) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /label="yoeC gene" promotor_-10 complement(1755199..1755218) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1755213) /Source="Nicolas_upshifts" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1755232..1755239) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1755475..1755705) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16880568; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excisionase" /protein_id="NP_389722.1" /db_xref="EnsemblGenomes-Gn:BSU18400" /db_xref="EnsemblGenomes-Tr:CAB13723" /db_xref="GOA:O34555" /db_xref="InterPro:IPR010093" /db_xref="SubtiList:BG13551" /db_xref="UniProtKB/Swiss-Prot:O34555" /translation="MYLTIEETAEYTNLSEDYIKSLVLEGKIRAVHDGEQFLIYKEQF KTHLEQLENYKALVQEILNEPIPEDIDVKDED*" /label="yoeD CDS" gene complement(1755475..1755705) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /label="yoeD gene" downshifts complement(1755489) /Source="Nicolas_upshifts" /id="D1008" /incds=0 /nref=193 /ntot=248 /MaxReadThrough="0.81591" /MaxDrop="5.75977" /score="19.8797745" /energy="-8.6" /TU="NA" /idTUdmin="U1490" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1755731..1755750) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1755743) /Source="Nicolas_upshifts" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1755762..1755768) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1755797..1755816) /Source="Nicolas_upshift_promotors" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1755807) /Source="Nicolas_upshifts" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1755820..1755827 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1755841..1755860 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1755845 /Source="Nicolas_upshifts" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="upshifts" CDS 1755890..1757653 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /EC_number="2.3.2.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8763966, 23335395, 24279353, 26370226, 28120195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763966, 23335395, 24279353, 26370226, 28120195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound gamma-glutamyltranspeptidase" /protein_id="NP_389723.1" /db_xref="EnsemblGenomes-Gn:BSU18410" /db_xref="EnsemblGenomes-Tr:CAB13724" /db_xref="GOA:P54422" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="PDB:2V36" /db_xref="PDB:3A75" /db_xref="PDB:3WHQ" /db_xref="PDB:3WHR" /db_xref="PDB:3WHS" /db_xref="SubtiList:BG11838" /db_xref="UniProtKB/Swiss-Prot:P54422" /translation="MKRTWNVCLTALLSVLLVAGSVPFHAEAKKPPKSYDEYKQVDVG KDGMVATAHPLASEIGADVLKKGGNAIDAAVAIQFALNVTEPMMSGIGGGGFMMVYDG KTKDTTIIDSRERAPAGATPDMFLDENGKAIPFSERVTKGTAVGVPGTLKGLEEALDK WGTRSMKQLITPSIKLAEKGFPIDSVLAEAISDYQEKLSRTAAKDVFLPNGEPLKEGD TLIQKDLAKTFKLIRSKGTDAFYKGKFAKTLSDTVQDFGGSMTEKDLENYDITIDEPI WGDYQGYQIATTPPPSSGGIFLLQMLKILDHFNLSQYDVRSWEKYQLLAETMHLSYAD RASYAGDPEFVNVPLKGLLHPDYIKERQQLINLDQVNKKPKAGDPWKYQEGSANYKQV EQPKDKVEGQTTHFTVADRWGNVVSYTTTIEQLFGTGIMVPDYGVILNNELTDFDAIP GGANEVQPNKRPLSSMTPTILFKDDKPVLTVGSPGGATIISSVLQTILYHIEYGMELK AAVEEPRIYTNSMSSYRYEDGVPKDVLSKLNGMGHKFGTSPVDIGNVQSISIDHENGT FKGVADSSRNGAAIGINLKRK*" /label="ggt CDS" gene 1755890..1757653 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /label="ggt gene" downshifts 1757634 /Source="Nicolas_upshifts" /id="D1009" /incds=0 /nref=24 /ntot=49 /MaxReadThrough="1.41914" /MaxDrop="5.80171" /score="3.23845421" /energy="-10.4" /TU="NA" /idTUdmin="U1492" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1757754..1758611) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17526699" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_389724.1" /db_xref="EnsemblGenomes-Gn:BSU18420" /db_xref="EnsemblGenomes-Tr:CAB13725" /db_xref="GOA:O34685" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13552" /db_xref="UniProtKB/Swiss-Prot:O34685" /translation="MESGDLKIFQAVAREGSITKAAQMLNYVQSNVTARVHNLEEDLN IRLFHRTNRGMKLTAAGENLLQYADQVLSLLDQAEKSTRMSRQPKGPLRIGSLETMAV THLPEHAASFLRRFPEVDLSVNTADTHHLIQQVLDHKVDGAFVYGPVEHAAVRQLHVS HDELVLISSREGTAEDMLQQPMLFFGAGCSHRDRVKRLLEEAGIHNQKIIEFGTLEAI IKGVSAGMGTALLPKSAVDGSEHRTNVWIHQLPPSYQDLEIVFIYRKDFFITSAFQTF LDEINEMKR*" /label="ftsR CDS" gene complement(1757754..1758611) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /label="ftsR gene" promotor_-10 complement(1758657..1758676) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1758677) /Source="Nicolas_upshifts" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1758690..1758697) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1758739..1759728 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 23873705; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389725.1" /db_xref="EnsemblGenomes-Gn:BSU18430" /db_xref="EnsemblGenomes-Tr:CAB13726" /db_xref="GOA:O35017" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13553" /db_xref="UniProtKB/Swiss-Prot:O35017" /translation="MKAVIHNGKAGLLGLSVQDVPSTKPGYGEVKVKLKSAGLNHRDL FLMKNKSEQDPHMILGSDGAGIIEEIGEGVKNVTVQTEVVIFPTLNWDLTENVPPVPE ILGGPSDGTLAEYVIIPSQNAIKKPAYLSWEEAGVLPLSALTAYRALFTKGQLKKGEH LLIPGIGSGVATYALFMAKAIGATVSVTSRSEEKRKKALKLGADYAFDSYSNWDEQLQ GKKIDVVLDSIGPALFSEYFRHVKPNGRIVSFGASSGDNLSFPVRSLFFPQVNVLGTS MGSGEEFQAMLAFIDKHKLRPVIDRIYPLEKACEAYKRMQEGRQFGNIGIVME*" /label="yogA CDS" gene 1758739..1759728 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /label="yogA gene" S_feature complement(1758795..1759753) /Source="Nicolas_S_feature" /locus_tag="new_2007582_2008540_c" /HighExp="T-4.40H, T-5.40H, Glu, GM 45, Glucon, GM-0.1, Gly, GM-0.2, UNK1, GM 90" /AntisenseName="yogA" /AntisenseCor="-0.49303153269799599" /AntisenseRegPval="-17.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S682" CDS complement(1759785..1761266) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3011766, 10651638, 11029411, 27223617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3011766, 10651638, 11029411, 27223617; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (small subunit, NADP-dependent)" /protein_id="NP_389726.2" /db_xref="EnsemblGenomes-Gn:BSU18440" /db_xref="EnsemblGenomes-Tr:CAB13727" /db_xref="GOA:O34399" /db_xref="InterPro:IPR006005" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR028261" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12594" /db_xref="UniProtKB/Swiss-Prot:O34399" /translation="MGKPTGFMEIKREKPAERDPLTRLKDWKEYSAPFSEEASKRQGA RCMDCGTPFCQIGADINGFTSGCPIYNLIPEWNDLVYRGRWKEALERLLKTNNFPEFT GRVCPAPCEGSCTLAISDPAVSIKNIERTIIDKGFENGWIQPRIPKKRTGKKVAIVGS GPAGLASADQLNQAGHSVTVFERADRAGGLLTYGIPNMKLEKGIVERRIKLLTQEGID FVTNTEIGVDITADELKEQFDAVILCTGAQKQRDLLIEGRDSKGVHYAMDYLTLATKS YLDSNFKDKQFIDAKGKDVIVIGGGDTGADCVATALRQKAKSVHQFGKHPKLPPARTN DNMWPEQPHVFTLEYAYEEAEAKFGRDPREYSIQTTKMVADKNGKLKELHTIQMEKVK NEHGKYEFRELPGTEKVWPAQLVFIAIGFEGTEQPLLKQFGVNSVNNKISAAYGDYQT NIDGVFAAGDARRGQSLIVWAINEGREVAREVDRYLMGSSVLP*" /label="gltB CDS" gene complement(1759785..1761266) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /label="gltB gene" downshifts complement(1759798) /Source="Nicolas_upshifts" /id="D1010" /incds=0 /nref=247 /ntot=279 /MaxReadThrough="3.292" /MaxDrop="7.52772" /score="10.4717228" /energy="-6.5" /TU="U1495" /idTUdmin="U1495" /TUdmin="-570" /isTUend="FALSE" /label="downshifts" CDS complement(1761283..1765845) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (large subunit, NADP-dependent)" /protein_id="NP_389727.2" /db_xref="EnsemblGenomes-Gn:BSU18450" /db_xref="EnsemblGenomes-Tr:CAB13728" /db_xref="GOA:P39812" /db_xref="InterPro:IPR002489" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR006982" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR036485" /db_xref="SubtiList:BG10811" /db_xref="UniProtKB/Swiss-Prot:P39812" /translation="MTYNQMPKAQGLYRPEFEHDACGIGLYAHLKGKQTHDIVKQGLK MLCQLDHRGGQGSDPDTGDGAGLLVQIPDAFFRKECKNINLPEKERYGVGMVFFSQKE DERKKIEKQINALIEQEGQVVLGWRTVPVNVGKIGTVAQKSCPFVRQVFIGASSDLKD NLSFERKLYVIRKQAENWGVTEGLDFYFASLSSQTIVYKGLLTPEQVDAFYSDLQDEA FVSAFALVHSRFSTNTFPTWERAHPNRYLVHNGEINTLRGNINWMRAREQQFVSESFG EDLNKILPILNADGSDSSILDNAFEFFVMAGRKPAHTAMMLIPEPWTENTHMSKEKRA FYEYHSSLMEPWDGPTAISFTDGKQIGAILDRNGLRPARYYVTKDDYIIFSSEVGVIE VEQENVLYKNRLEPGKMLLIDLEEGRIISDEEVKTQIATEYPYQKWLEEELVQVNPDP ESREEEQFSDLLTRQKAFGYTYEDIQKYLIPVIKEGKDPLGSMGNDAPLAVLSDRAQS LFNYFKQLFAQVTNPPIDAIREQLVTSTMTWLGAEGDLLHPSERNVRRIKLYTPVLSN EQFYALKTIVHPDLKSQKIDVLFSEDLERGLKDMFTQAEKAISQGVSLLILSDKKMNE RLTPIPPLLAVSALHQHLIRKGLRTKVSIIVESGEAREVHHFAALIGYGADAINPYLA YATYKQEIDEGRLDISYEEAVSKYGKSITEGVVKVMSKMGISTVQSYRGAQIFEAVGI SRDVIDRYFSGTASQLGGIDLQTIAEEAQRRHREAYQDDYSKTLEPGSDFQWRNGGEH HAFNPKTIHTLQWACRRNDYNLFKQYTKAADEERIGFLRNLFAFDGNRKPLKLEEVES AESIVKRFKTGAMSFGSLSKEAHEALAIAMNRLGGKSNSGEGGEDPKRFVPDENGDDR RSAIKQIASGRFGVKSHYLVNADELQIKMAQGAKPGEGGQLPGNKVYPWVADVRGSTP GVGLISPPPHHDIYSIEDLAQLIHDLKNANRDARISVKLVSKAGVGTIAAGVAKATAD VIVISGYDGGTGASPKTSIKHTGLPWELGLAEAHQTLMLNGLRDRVVLETDGKLMTGR DVVMAALLGAEEFGFATAPLVVLGCVMMRACHLDTCPVGVATQNPELRKKFMGDPDHI VNYMLFIAEEVREYMAALGFKTFDEMIGRTDVLHASERAKEHWKASQLDLSTLLYQPE GVRTFQSPQNHKIDQSLDITTILPAVQEAIESGKEADISIEINNTNRVAGTITGSEIS KRYGEEGLPEDTIKLHFTGSAGQSFGAFVPKGMTLYLDGDSNDYVGKGLSGGKIIVKS SEGFNSASDDNVIIGNVAFYGATSGEAYINGRAGERFAVRNSGVNVVVEGIGDHGCEY MTGGSVVVLGDVGKNFAAGMSGGIAYVLTEDVKAFKRKCNLEMILFESLEDEKEIQQI KAMLERHTAYTNSQKAEDLLDQWEDSVKKFVKVIPKNYKQMLASIEEQKAAGLSDEEA IMFAFEANTKPKQNTAASGQKQAVVQ*" /label="gltA CDS" gene complement(1761283..1765845) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /label="gltA gene" promotor_no_box 1764306..1764406 /Source="Nicolas_upshift_promotors" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1764366 /Source="Nicolas_upshifts" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1765846..1765917) /Source="Nicolas_S_feature" /locus_tag="new_2014633_2014704_c" /HighExp="SMM, T-5.40H, HiOs, MG 15, Glu, T-4.40H, MG 150, MG 60, UNK1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S683" promotor_-10 complement(1765897..1765916) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1765914..1765921 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1765917) /Source="Nicolas_upshifts" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1765931..1765938) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1765933 /Source="Nicolas_upshifts" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1765936..1765955 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1765992..1766894 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2548995, 15150225, 17134717, 28294562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2548995, 15150225, 17134717, 28294562; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family) (GltC-glutamate)" /protein_id="NP_389728.2" /db_xref="EnsemblGenomes-Gn:BSU18460" /db_xref="EnsemblGenomes-Tr:CAB13729" /db_xref="GOA:P20668" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10810" /db_xref="UniProtKB/Swiss-Prot:P20668" /translation="MELRQLRYFMEVAEREHVSEAADHLHVAQSAISRQIANLEEELN VTLFEREGRNIKLTPIGKEFLIHVKTAMKAIDYAKEQIDEYLDPHRGTVKIGFPTSLA SQLLPTVISAFKEEYPHVEFLLRQGSYKFLIEAVRNRDIDLALLGPVPTNFSDITGKI LFTEKIYALVPLNHPLAKQKTVHLIDLRNDQFVLFPEGFVLREMAIDTCKQAGFAPLV STEGEDLDAIKGLVSAGMGVTLLPESTFAETTPRFTVKIPIEFPQVKRTVGIIKPKNR ELAPSANDFYEFVIQFFSKLEQYQ*" /label="gltC CDS" gene 1765992..1766894 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /label="gltC gene" downshifts 1766874 /Source="Nicolas_upshifts" /id="D1011" /incds=0 /nref=104 /ntot=241 /MaxReadThrough="2.84467" /MaxDrop="3.98111" /score="22.3639229" /energy="-13.6" /TU="NA" /idTUdmin="U1496" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1766946..1768061) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /EC_number="2.7.2.11" /function="16.8: Protect" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:11418582, 15804359, 21784929, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 15804359, 21784929, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389729.1" /db_xref="EnsemblGenomes-Gn:BSU18470" /db_xref="EnsemblGenomes-Tr:CAB13740" /db_xref="GOA:O07509" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG12658" /db_xref="UniProtKB/Swiss-Prot:O07509" /translation="MTPDTSMKRVVVKIGSSSLTSLHGEISIRKLEALVDQVVKLKDA GYEVILVSSGAVAAGYRKLGFIQRPEKLPEKQASASIGQGLLMEAYSKLFLAHGYVAS QILITRSDFSDEYRYNNVRNTMNVLLERGIIPIINENDTVTVNRLKFGDNDTLAAKVA GLIDADMLVILSDIDGLYDGNPRTNPEAKKIQRVSEITPDIEACAGDTGSIVGTGGMR SKLDAFKIVMASGIKGFLGQADAGDILYHAVHEQAEGTYFEAEGTLPLNQKEQWIAFN SGPEGEMILSDDCSRKITNGQSSLYLDGVQKIKGKFKSGSVVRLMDSKGTEIGLGIVN YSSVQLQEPEKKKELTNRALIDQEAFVCHVDFSLPVN*" /label="proJ CDS" gene complement(1766946..1768061) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /label="proJ gene" CDS complement(1768058..1768951) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21784929, 22139509, 25344233, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21784929, 22139509, 25344233, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase" /protein_id="NP_389730.2" /db_xref="EnsemblGenomes-Gn:BSU18480" /db_xref="EnsemblGenomes-Tr:CAB13741" /db_xref="GOA:P0CI77" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11049" /db_xref="UniProtKB/Swiss-Prot:P0CI77" /translation="MRTKKRTKEMLPIFDQKKVAFIGAGSMAEGMISGIVRANKIPKQ NICVTNRSNTERLTELELQYGIKGALPNQLCIEDMDVLILAMKPKDAENALSSLKSRI QPHQLILSVLAGITTSFIEQSLLNEQPVVRVMPNTSSMIGASATAIALGKYVSEDLKK LAEALLGCMGEVYTIQENQMDIFTGIAGSGPAYFYYLMEFIEKTGEEAGLDKQLSRSI GAQTLLGAAKMLMETGEHPEILRDNITSPNGTTAAGLQALKKSGGGEAISQAIKHAAK RSKEISEDIEKTAAPLSGVIK*" /label="proH CDS" gene complement(1768058..1768951) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /label="proH gene" promotor_-10 complement(1768956..1768975) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1768964 /Source="Nicolas_upshifts" /id="D1012" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="1.17009" /MaxDrop="3.27004" /score="-0.988973561" /energy="-13.3" /TU="NA" /idTUdmin="U1496" /TUdmin=2090 /isTUend="FALSE" /label="downshifts" upshifts complement(1768974) /Source="Nicolas_upshifts" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1768989..1768995) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1769004..1769022) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1769022) /Source="Nicolas_upshifts" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1769038..1769043) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1769099..1769467) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11313334, 15657033, 16822523, 17376071, 17521668, 24946150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11313334, 15657033, 16822523, 17376071, 17521668, 24946150; Product type f : factor" /codon_start=1 /transl_table=11 /product="replication terminator protein" /protein_id="NP_389731.1" /db_xref="EnsemblGenomes-Gn:BSU18490" /db_xref="EnsemblGenomes-Tr:CAB13742" /db_xref="GOA:P0CI76" /db_xref="InterPro:IPR003432" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1BM9" /db_xref="PDB:1F4K" /db_xref="PDB:1J0R" /db_xref="PDB:2DPD" /db_xref="PDB:2DPU" /db_xref="PDB:2DQR" /db_xref="PDB:2EFW" /db_xref="SubtiList:BG10738" /db_xref="UniProtKB/Swiss-Prot:P0CI76" /translation="MKEEKRSSTGFLVKQRAFLKLYMITMTEQERLYGLKLLEVLRSE FKEIGFKPNHTEVYRSLHELLDDGILKQIKVKKEGAKLQEVVLYQFKDYEAAKLYKKQ LKVELDRCKKLIEKALSDNF*" /label="rtp CDS" gene complement(1769099..1769467) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /label="rtp gene" promotor_-10 complement(1769502..1769520) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-10" upshifts complement(1769525) /Source="Nicolas_upshifts" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="upshifts" S_feature complement(1769527..1769646) /Source="Nicolas_S_feature" /locus_tag="new_2018314_2018433_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, LBGtran, LoTm, LBGexp, G180, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S684" promotor_-35 complement(1769532..1769540) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-35" promotor_-10 complement(1769638..1769657) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1769646) /Source="Nicolas_upshifts" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1769648..1769744) /Source="Nicolas_S_feature" /locus_tag="new_2018435_2018531_c" /HighExp="Etha, dia15, LBGtran, LoTm, dia5, H2O2, LBGexp, M0t45, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S685" promotor_-35 complement(1769672..1769679) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1769767..1770483) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxido-reductase" /protein_id="NP_389732.1" /db_xref="EnsemblGenomes-Gn:BSU18500" /db_xref="EnsemblGenomes-Tr:CAB13743" /db_xref="GOA:P14802" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11048" /db_xref="UniProtKB/Swiss-Prot:P14802" /translation="MQSLQHKTALITGGGRGIGRATALALAKEGVNIGLIGRTSANVE KVAEEVKALGVKAAFAAADVKDADQVNQAVAQVKEQLGDIDILINNAGISKFGGFLDL SADEWENIIQVNLMGVYHVTRAVLPEMIERKAGDIINISSTAGQRGAAVTSAYSASKF AVLGLTESLMQEVRKHNIRVSALTPSTVASDMSIELNLTDGNPEKVMQPEDLAEYMVA QLKLDPRIFIKTAGLWSTNP*" /label="yoxD CDS" gene complement(1769767..1770483) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /label="yoxD gene" downshifts complement(1769789) /Source="Nicolas_upshifts" /id="D1013" /incds=0 /nref=109 /ntot=217 /MaxReadThrough="4.9568" /MaxDrop="5.08605" /score="27.1231718" /energy="-7.5" /TU="U1501" /idTUdmin="U1500" /TUdmin="-594" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1770521..1770540) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1770530) /Source="Nicolas_upshifts" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1770556..1770559) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1770584..1770590 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1770604..1770622 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1770609 /Source="Nicolas_upshifts" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="upshifts" CDS 1770634..1770939 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16513748, 17598888; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="transition-dependent and sulfur-related metabolism protein" /protein_id="NP_389733.1" /db_xref="EnsemblGenomes-Gn:BSU18510" /db_xref="EnsemblGenomes-Tr:CAB13744" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG11047" /db_xref="UniProtKB/Swiss-Prot:P28670" /translation="MIIVYISLAVLAVSIIFLGVTVIQNKKKIDPALKELSSVTQAMQ KQIEGLKTETELLTQKQKKIQQDVQIKKYTLQQTAAEVKEVPQAVKEVWQAGHFNSR* " /label="yoxC CDS" gene 1770634..1770939 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /label="yoxC gene" downshifts 1770923 /Source="Nicolas_upshifts" /id="D1014" /incds=0 /nref=6 /ntot=88 /MaxReadThrough="5.31272" /MaxDrop="3.8396" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin="-1473" /isTUend="FALSE" /label="downshifts" CDS 1771010..1771780 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 17598888, 19703276" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389734.1" /db_xref="EnsemblGenomes-Gn:BSU18520" /db_xref="EnsemblGenomes-Tr:CAB13745" /db_xref="InterPro:IPR020530" /db_xref="InterPro:IPR036895" /db_xref="SubtiList:BG11046" /db_xref="UniProtKB/Swiss-Prot:P28671" /translation="MIINRSCLKEFAEKVHFLPSSLTKSDLLTDPFRLHQENELGIYY SPHNEFINRDASLVIAGITPGFSQMKTAYETAAESLLQGGTLEQMAVDTKIAAGFSGS MRHNLITMLDLCGLPQAFGIQSAAKLFGELRHMLHTTSVIKYPVFIQQKNYTGYKPAI THSPILSTYAFGHFPAELNHVTGPALLIPLGKAAETVCETLIRQHSLQNLICLNGFPH PSGANGHRLKQFSKNKEQLERQIRSFAALVDFAIEKRK*" /label="yoxB CDS" gene 1771010..1771780 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /label="yoxB gene" promotor_-35 1771762..1771769 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1771781 /Source="Nicolas_upshifts" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1771784..1771803 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1771824..1772357 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 11717291, 17598888; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389735.2" /db_xref="EnsemblGenomes-Gn:BSU18530" /db_xref="EnsemblGenomes-Tr:CAB13746" /db_xref="GOA:O34569" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13472" /db_xref="UniProtKB/Swiss-Prot:O34569" /translation="MFPILETDRLILRQITDQDAEAIFACFSNDEVTRYYGLENMESI EQAISMIQTFAALYQEKRGIRWGIERRDTKELIGTIGFHALAQKHRRAEIGYEIIPEH WRNGFASEVISKVVSYGFSALGLSRIGAVVFTDNEASNRLLLKMGFQKEGVLRQYMYQ NGTPYDTNVYSIVKPRE*" /label="yoaA CDS" gene 1771824..1772357 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /label="yoaA gene" S_feature 1772358..1772443 /Source="Nicolas_S_feature" /locus_tag="new_2021145_2021230" /HighExp="Salt, Sw, B60, LoTm, B36, M9-stat, BC, Lbstat, HiTm, Etha" /AntisenseName="yoaB" /AntisenseCor="-0.17521117067018899" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S686" downshifts 1772400 /Source="Nicolas_upshifts" /id="D1015" /incds=0 /nref=6 /ntot=100 /MaxReadThrough="4.32682" /MaxDrop="3.67936" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(1772436..1773680) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12193636, 15849754, 16513748, 16850406, 28546427; Product type t : transporter" /codon_start=1 /transl_table=11 /product="negatively charged metabolite transporter" /protein_id="NP_389736.1" /db_xref="EnsemblGenomes-Gn:BSU18540" /db_xref="EnsemblGenomes-Tr:CAB13747" /db_xref="GOA:O34864" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13473" /db_xref="UniProtKB/Swiss-Prot:O34864" /translation="MLDKIGIPKRLAWGFLGVVLFMMGDGLEQGWLSPFLIENGLTVQ QSASIFSIYGIALAIASWFSGVCLEAFGAKRTMFMGLLFYVIGTAAFIVFGFEQLNLP VMYVTYFVKGLGYPLFAYSFLTWVIYRTPQSKLSTAVGWFWIAYCLGMFVFGAWYSSY AIKAFGYLNTLWSSIFWVCLGAFFALFINKDRFEKKKRKRSETAEELLKGVTILFTNP RVLTGGIIRIINSIGTYGFPVFLPMHMAQHGISTNVWLQIWGTIFLGNIVFNLIFGIV GDKFGWKNTVIWFGGVGCGIFTVLLYYAPVFSGGSLAVVSVIGFIWGGLLAGYVPIGA IVPTVAGKDKGAAMSVLNLAAGLSAFVGPALAWLFIGLVGAQGVVWIFAALYLASAVL TKCIHIPEEKAVKEETSPQYAS*" /label="yoaB CDS" gene complement(1772436..1773680) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /label="yoaB gene" S_feature 1772445..1773184 /Source="Nicolas_S_feature" /locus_tag="new_2021232_2021971" /HighExp="LoTm, Salt, Sw, S6, Etha, M9-stat, LPhT, B60, T2.0H, T2.30H" /AntisenseName="yoaB" /AntisenseCor="-0.18536963552729299" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S687" downshifts complement(1772450) /Source="Nicolas_upshifts" /id="D1016" /incds=0 /nref=32 /ntot=113 /MaxReadThrough="2.59019" /MaxDrop="4.97477" /score="29.0246554" /energy="-12.5" /TU="NA" /idTUdmin="U1504" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1773681..1773773) /Source="Nicolas_S_feature" /locus_tag="new_2022468_2022560_c" /HighExp="MG 10, MG 5, BMM, MG t5, MG 15, GM 25, HiTm, UNK1, GM 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S688" CDS complement(1773774..1775237) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10094622, 12193636, 16850406, 18039762, 21749987, 27795321, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxylated metabolite kinase" /protein_id="NP_389737.1" /db_xref="EnsemblGenomes-Gn:BSU18550" /db_xref="EnsemblGenomes-Tr:CAB13748" /db_xref="GOA:O34861" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG13474" /db_xref="UniProtKB/Swiss-Prot:O34861" /translation="MKKQKGYLVFDIGTGNARVAVVSVTGSVLTVEREDIEYSTETLY PDSRYFSPQVLWKQVMNLAKRALSRSCDIDIIGLTSTSQRQGIVLIDQNGNPFLGLPN IDNRGREWEAGIPDWEEIYSSTGRLPTALFSALKLYGLKQRQPSLWEKTASFTSISDW VTYQLSGILTYEPSQATETLLFDVKQNTWSEEMCDIFGFSPSILPPLVRAGTAIGTIA NEYASELGLSINAKVIAGGGDTQLAVKSTGAGLEDIVIVSGTTTPITKITEDHGDTKH KAWLNCHTDQGHWLVETNPGITGLNYQKLKQIFYPNETYEVMEEEISALAKEDHACVA ALGSYLSAEKNALTRGGFLFDAPLSAHLKRAHFVRAALEEIAFSIKWNFDILTEVTPF ERDYVWVCGGGFQSKALTQYIADLLQKKVYVQEGYHQASVVGAAVICNETFQLTEEMS ANVRVIEPKDCQIELALYEEWKQTQRFFSGSESKVLI*" /label="yoaC CDS" gene complement(1773774..1775237) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /label="yoaC gene" CDS complement(1775255..1776289) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10094622, 11390694, 12193636, 17012385, 18039762, 21749987, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-hydroxyacid dehydrogenase" /protein_id="NP_389738.1" /db_xref="EnsemblGenomes-Gn:BSU18560" /db_xref="EnsemblGenomes-Tr:CAB13749" /db_xref="GOA:O34815" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13475" /db_xref="UniProtKB/Swiss-Prot:O34815" /translation="MKNTMKRMFCSMTVLVTAPYNEEGRKELENLFGSVAYQSWKEQG RAYREDELIQLLKATNATGLITELDQVTDSVFASVPELSFVGVCRGMPSNVDVAAASK RGIPVFYTPGRNAQAVAEMFIGNVISFLRHTSASNQWLKDGEWDSDYLQAYVKFKGNE LTGKTVGMIGFGAVGQRIAKLLTAFDCKIKYYDPYIQDDHPLYEKASLKTVFSDSDIV SVHLPRTEETLGLIDRQYFDLMKESAIFVNTSRAVVVNREDLLFVLKEHKISGAILDV FYHEPPEESDYELISLPNVLATPHLAGATFEVEDHHVTILNKALKKWKGEKTLNIQTM YNKDALKTGG*" /label="yoaD CDS" gene complement(1775255..1776289) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /label="yoaD gene" S_feature complement(1776301..1776372) /Source="Nicolas_S_feature" /locus_tag="new_2025088_2025159_c" /HighExp="MG t5, MG 5, MG 10, BMM, GM 25, MG 15, Heat, GM 15, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S689" downshifts complement(1776344) /Source="Nicolas_upshifts" /id="D1017" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="7.78218" /MaxDrop="4.81701" /score="26.3160061" /energy="-11.4" /TU="U1504" /idTUdmin="U1507" /TUdmin=2727 /isTUend="FALSE" /label="downshifts" misc_RNA complement(1776373..1776464) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /product="AdoMet riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswF RNA" gene complement(1776373..1776464) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /label="mswF gene" promotor_-10 complement(1776492..1776511) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1776504) /Source="Nicolas_upshifts" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1776526..1776533) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1776546..1776553 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1776567..1776586 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1776571 /Source="Nicolas_upshifts" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="upshifts" CDS 1776613..1778655 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170332, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin cofactor oxido-reductase" /protein_id="NP_389739.2" /db_xref="EnsemblGenomes-Gn:BSU18570" /db_xref="EnsemblGenomes-Tr:CAB13750" /db_xref="GOA:C0SP82" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG13476" /db_xref="UniProtKB/Swiss-Prot:C0SP82" /translation="MRSFATQQNGIFKSVCSLDCPDQCGLLIHKKDGKIVKVQGDPDH PVTAGNICNKVRNMTERIYDEKRLTTPLKRTGAKGQAIFEPISWKEAIDTITSRWKQL IDEEGAESILPYSFYGNMGKLTAEGMDRRFFYRMGSSQLERTICSKAGSEGYKYTMGI SAGIDPEETVHTKLFIFWGINAVSTNMHQITIAQKARKKGAKIVVIDVHKNQTGRLAD WFIPIKPGTDSALALGIMHILFKENLHDEAFLSEYTVGYEELREHVKQYDPEKVSTIT GVSTEDIYRLAKMYGETSPSFIRIGNGPQHHDNGGMIVRTIACLPAITGQWLHTGGGA IKHNSGILEYNTNALQRPDLLKGRTPRSFNMNQLGRVLLETDPPIRSLFIYGTNPAVV APEANKVRQGLLREDLFTVVHDLFLTETAAYADIVLPATSAFENTDFYTSYWHHYIQL QQPVIERYGESKSNTEVFRLLAEAMGFTDQELKDSDEVLIRQALDHPDNPHLAEIDYD SLTKHSFMKAKREKPLFPGELPTPSGKIELYSEKMKQDGFPALPTYTPLVTDNEHPFM YVPGPNHNFLNSTFSNNEKHIKLEKTPKLFINTKDAEKHGIVDGAPVRIWNSRGECEL TAAVGEQVLPGVVVSQGLWADEQGKKQLVNALTPDRLSDMGGGATFFSGRVQIEKV*" /label="yoaE CDS" gene 1776613..1778655 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /label="yoaE gene" promotor_-35 1778663..1778672 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1778685..1778700 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1778688 /Source="Nicolas_upshifts" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="upshifts" CDS 1778722..1779015 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389740.1" /db_xref="EnsemblGenomes-Gn:BSU18580" /db_xref="EnsemblGenomes-Tr:CAB13751" /db_xref="SubtiList:BG13477" /db_xref="UniProtKB/Swiss-Prot:O31829" /translation="MDVFLGIGIALAGYFIGEGLKQRNQTKGNEQNDIFLIKERDIYF YIGLFLGITTTEAKQLAGDMADLPYIEINGKKYVQKHMLKDWTFTLVEKHQGE*" /label="yoaF CDS" gene 1778722..1779015 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /label="yoaF gene" downshifts 1778995 /Source="Nicolas_upshifts" /id="D1018" /incds=0 /nref=97 /ntot=243 /MaxReadThrough="3.40762" /MaxDrop="4.1662" /score="-6.27063114" /energy="-3.9" /TU="U1506" /idTUdmin="U1505" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1779040..1779387) /Source="Nicolas_S_feature" /locus_tag="new_2027827_2028174_c" /HighExp="T0.30H, S0, T1.0H, aero, Etha, S8, SMMPr, T-0.40H, ferm, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S690" downshifts complement(1779071) /Source="Nicolas_upshifts" /id="D1019" /incds=0 /nref=43 /ntot=202 /MaxReadThrough="2.3171" /MaxDrop="4.25059" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1507" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1779388..1779792) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 15849754, 16850406, 20011599, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage-related membrane protein" /protein_id="NP_389741.1" /db_xref="EnsemblGenomes-Gn:BSU18590" /db_xref="EnsemblGenomes-Tr:CAB13752" /db_xref="GOA:O31830" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG13478" /db_xref="UniProtKB/Swiss-Prot:O31830" /translation="MKKIASYYLMTLGLSSLTFGLLLGFYSFVMYGDMIIALFTAAIA LLYGFVVYGLFAVPLQMKLQKKARTFNVMYLLIYSVVAFIAAFLFFVINEPASIAWTL QSYFYYMLSIAAAVIYWLWDSLILYKRTASGV*" /label="yoaG CDS" gene complement(1779388..1779792) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /label="yoaG gene" S_feature complement(1779793..1779888) /Source="Nicolas_S_feature" /locus_tag="new_2028580_2028675_c" /HighExp="T0.30H, T1.0H, T0.0H, T-0.40H, S0, T-1.10H, T-1.40H, SMMPr, Salt, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S691" promotor_-10 complement(1779878..1779893) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1779878..1779997) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513962.1" /translation="MHFFHSRFGQSGEAFSASVLSNKRTSFLKPFISALRIAR*" /label="hypothetical protein CDS" gene complement(1779878..1779997) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /label="gene" upshifts complement(1779888) /Source="Nicolas_upshifts" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1779906..1779915) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1779993..1779999 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1780013..1780024 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1780024..1780232 /Source="Nicolas_S_feature" /locus_tag="new_2028811_2029019" /HighExp="S5, S8, S7, S6, S4, ferm, BT, nit, T5.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99998799999999999" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S692" upshifts 1780024 /Source="Nicolas_upshifts" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="upshifts" CDS 1780067..1780189 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513963.1" /db_xref="EnsemblGenomes-Gn:BSU18596" /db_xref="EnsemblGenomes-Tr:CCQ48597" /db_xref="UniProtKB/TrEMBL:L8E9J0" /translation="MSKKGIQNSSIEQIRNDHETETAFKADDPKKHGSDPKRTK*" /label="conserved hypothetical protein CDS" gene 1780067..1780189 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /label="gene" CDS 1780233..1780526 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="YP_054581.1" /db_xref="EnsemblGenomes-Gn:BSU18600" /db_xref="EnsemblGenomes-Tr:CAE01456" /db_xref="InterPro:IPR025100" /db_xref="SubtiList:BG14189" /db_xref="UniProtKB/Swiss-Prot:Q7WY68" /translation="MTQKNGADRPDDYKRFSSLDKEYDFQQSIRSNTETESVNTETQT HNKENKNDTTDVAGKYFEPSDYKGSTQLEKGLAETHEQVSDDYFEGTIDQNLD*" /label="yozQ CDS" gene 1780233..1780526 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /label="yozQ gene" S_feature 1780527..1780620 /Source="Nicolas_S_feature" /locus_tag="new_2029314_2029407" /HighExp="S5, S8, S6, S7, S4, BT, ferm, nit, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S693" downshifts 1780577 /Source="Nicolas_upshifts" /id="D1020" /incds=0 /nref=14 /ntot=74 /MaxReadThrough="3.32407" /MaxDrop="3.87581" /score="-6.27063114" /energy="-3.9" /TU="U1508" /idTUdmin="U1506" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1780642..1782327) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting chemotaxis protein" /protein_id="NP_389742.2" /db_xref="EnsemblGenomes-Gn:BSU18610" /db_xref="EnsemblGenomes-Tr:CAB13753" /db_xref="GOA:C0SP89" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR007891" /db_xref="SubtiList:BG13479" /db_xref="UniProtKB/Swiss-Prot:C0SP89" /translation="MKVKTKLLGIISILVVSIIGIGGSSVFMISSTVKKNEELKDKME FQKEIKHIQYELTGLSNDERGFLITRDKEYDEGMKGKADDVLKSLDRVNDLIDEEKYQ SNIEDIKTSFTQYRALNQQVVTAYSSNPKKAETIHFGEERTIRKEGVAPAVNKLSDRL DQEVEDLKDEIQGNGKMSQSLIIIVTGISVILGIVLSIMLLKSIMVPLRSINKQLEEI AHGEADLTKKVIVKNKDEFGQLAQSFNSFTHSLTQIVKQISSSSEQVAASSEELSASA EESKSTSEHISRAMQMAADSNVKQSSMTEKSAESITELLDSISSVASNTGNIADLSSS MRDKAEIGSKSVNKMLDQMKFIDKSVDSAGNGLQTLVASTAEISDISSLITTISEQTN LLALNAAIEAARAGEQGKGFAVVAEEVRKLADETNKSANHIQSVVATIQNESIETVNN IKVVQENVSSGIVLSQETTGNFNEILNLVEQVTSQIQEVAAATQQLTSGVEVIQHTVH TLAAGTKETSANTEAVANSSQEQLHSMGEISYAAESLSQLAEELQTVINRFKY*" /label="yoaH CDS" gene complement(1780642..1782327) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /label="yoaH gene" downshifts complement(1780654) /Source="Nicolas_upshifts" /id="D1021" /incds=0 /nref=68 /ntot=193 /MaxReadThrough="2.22411" /MaxDrop="4.20676" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1509" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" S_feature complement(1782328..1782415) /Source="Nicolas_S_feature" /locus_tag="new_2031115_2031202_c" /HighExp="Cold, C30, LBGstat, GM 90, GM 15, GM 45, GM 25, GM 60, GM 10, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115923" /TUshortSig="SigD" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S694" promotor_-10 complement(1782407..1782425) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1782415) /Source="Nicolas_upshifts" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1782439..1782446) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1782584..1782593 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1782603 /Source="Nicolas_upshifts" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1782606..1782625 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1782652..1784103 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /EC_number="1.14.14.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 4-hydroxyphenylacetate-3-hydroxylase" /protein_id="NP_389743.2" /db_xref="EnsemblGenomes-Gn:BSU18620" /db_xref="EnsemblGenomes-Tr:CAB13754" /db_xref="GOA:C0SPC0" /db_xref="InterPro:IPR004925" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR012687" /db_xref="InterPro:IPR024674" /db_xref="InterPro:IPR024719" /db_xref="InterPro:IPR036250" /db_xref="SubtiList:BG13480" /db_xref="UniProtKB/Swiss-Prot:C0SPC0" /translation="MGIINGKEFIDRLNKLENEIWYDGEKIKGNISEHPAFKGIIKTK SSLYELQTKDELIHEMTYCLPGDHNRIGLSYLQPKTKNDLKKRRTMIEHWARHTHGMM GRSPDYMNTVMMSFASSAELLKDKENCFPEHILDMYEQAAKHDLSFTHTFITPQVNRS QSYFGLSEKPISAKVIDRTEKGLMIHGARLLATQGGLTDEILVFSAPKFFFETDEAYA FSIPSNTKGVKFITRESFVLSDSSFNHPLSSRYEEMDSIVVFDHVLVPWNRVFFYDNV EAAKDFMTKSSFHAFTFHQVVIRQMIKIEFLLGVAQLLVDTINVSEYQHIQEKLSEII VGLETIKALIDKSENDAQLDEFGYMRPCLIPLQVISTIIPKLYPRFTEIIQLIGASGM VTLPTENAFDSEIREDLDQYLQATNTNAEERVKIFRLAWDLTMSSFGTRQTHYERYFF GDPIRISSRLYTSYPKQEQLNMIKTFLHADTEH*" /label="yoaI CDS" gene 1782652..1784103 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /label="yoaI gene" downshifts 1784079 /Source="Nicolas_upshifts" /id="D1022" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="2.84304" /MaxDrop="2.93575" /score="2.7297367" /energy="-12" /TU="U1510" /idTUdmin="U1510" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1784140..1784838) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 18971341, 26751268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 18971341, 26751268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular endoglucanase precursor (expansin)" /protein_id="NP_389744.1" /db_xref="EnsemblGenomes-Gn:BSU18630" /db_xref="EnsemblGenomes-Tr:CAB13755" /db_xref="GOA:O34918" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036749" /db_xref="InterPro:IPR036908" /db_xref="PDB:2BH0" /db_xref="PDB:3D30" /db_xref="PDB:4FER" /db_xref="PDB:4FFT" /db_xref="PDB:4FG2" /db_xref="PDB:4FG4" /db_xref="SubtiList:BG13481" /db_xref="UniProtKB/Swiss-Prot:O34918" /translation="MKKIMSAFVGMVLLTIFCFSPQASAAYDDLHEGYATYTGSGYSG GAFLLDPIPSDMEITAINPADLNYGGVKAALAGSYLEVEGPKGKTTVYVTDLYPEGAR GALDLSPNAFRKIGNMKDGKINIKWRVVKAPITGNFTYRIKEGSSRWWAAIQVRNHKY PVMKMEYEKDGKWINMEKMDYNHFVSTNLGTGSLKVRMTDIRGKVVKDTIPKLPESGT SKAYTVPGHVQFPE*" /label="exlX CDS" gene complement(1784140..1784838) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /label="exlX gene" downshifts complement(1784155) /Source="Nicolas_upshifts" /id="D1023" /incds=0 /nref=6 /ntot=95 /MaxReadThrough="0.66874" /MaxDrop="3.60414" /score="1.1918692" /energy="-7.7" /TU="NA" /idTUdmin="U1511" /TUdmin=132 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1784873..1784892) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1784892) /Source="Nicolas_upshifts" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1784894..1785107) /Source="Nicolas_S_feature" /locus_tag="new_2033681_2033894_c" /HighExp="G135, H2O2, G150, G180, LBGstat, dia15, LBGtran, Paraq, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S695" promotor_-35 complement(1784906..1784913) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1785108..1785785) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_389745.1" /db_xref="EnsemblGenomes-Gn:BSU18640" /db_xref="EnsemblGenomes-Tr:CAB13756" /db_xref="GOA:O34343" /db_xref="InterPro:IPR010699" /db_xref="SubtiList:BG13482" /db_xref="UniProtKB/Swiss-Prot:O34343" /translation="MTAAAYRNTLLSLLCLTAGIVDVIGYLSLGHVFTANMTGNIVLL GLAIGKSIQVTVFNSLTALIGFICGVIIATLMVGKAENTLWPSAVTKALALEAFILFV FACLSFYRAFVPVHILIILMSISMGIQTTAAKKLGIAGISSTVLTGTLASLLEDISGR LFFKKQKKTFLRDTVLRALAIILYCVGAIIVALAEPDFYHFIIWVPIVLIFGIMMTAK LKLSGEK*" /label="yoaK CDS" gene complement(1785108..1785785) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /label="yoaK gene" S_feature complement(1785786..1788275) /Source="Nicolas_S_feature" /locus_tag="new_2034573_2037062_c" /HighExp="LBGstat, G135, H2O2, G180, LBGtran, G150, dia15, Paraq, S0, Diami" /AntisenseName="pelB" /AntisenseCor="0.19898265589133701" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S696" CDS 1785958..1786995 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /EC_number="4.2.2.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1731776, 2018526, 2185758, 7764549, 22695924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-pectin lyase" /protein_id="NP_389746.1" /db_xref="EnsemblGenomes-Gn:BSU18650" /db_xref="EnsemblGenomes-Tr:CAB13757" /db_xref="GOA:O34819" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12643" /db_xref="UniProtKB/Swiss-Prot:O34819" /translation="MKRLCLWFTVFSLFLVLLPGKALGAVDFPNTSTNGLLGFAGNAK NEKGISKTGTTGGKNGQIVYIQSVNDLKTHLGGSTPKILVLQNDLSASAKTTVTIGSN KTLVGSYAKKTLKNIYLTTSSAFGNVIFQNLTFEHSPQINGNNDIQLYLDSGMNYWID HVTFSGHSYNASGSDLDKLVYIGKSADYITISNSKFANHKYGLILGYPDDSQHQYDGY PHMTIANNYFENLYVRGPGLMRYGYFHVKNNYSNNFNQAITIATKAKIYSEYNYFGKG SEKGGILDDKGTGYFKDIGSYPSLNKQTSPLTSWNPGSNYSYRVQTPEYTKEFVTKYA GSQSTTLVFGY*" /label="pelB CDS" gene 1785958..1786995 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /label="pelB gene" promotor_-35 1787192..1787198 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1787213..1787224 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1787225 /Source="Nicolas_upshifts" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="upshifts" CDS 1787252..1787935 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23945014, 26070154; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative SOS response associated protein; defective prophage 6" /protein_id="NP_389747.1" /db_xref="EnsemblGenomes-Gn:BSU18660" /db_xref="EnsemblGenomes-Tr:CAB13758" /db_xref="GOA:O34906" /db_xref="InterPro:IPR003738" /db_xref="InterPro:IPR036590" /db_xref="SubtiList:BG13483" /db_xref="UniProtKB/Swiss-Prot:O34906" /translation="MCGRFTLYSAFDDIIDQFDIDQFFPKGEYQPSYNVAPSQNILAI INDGSNNRLGKLRWGLIPPWAKDEKIGYKMINARAETITEKPAFRRPLVSKRCIIPAD SFYEWKRLDSKTKIPMRIKLKSSALFAFAGLYEKWSTHQGYPLYTCTIITTEPNEFMK DIHDRMPVILAHDHEKEWLNPKNTSPDYLQSLLLPYDADDMEAYQVSSLVNSPKNNSA ELLDAENHM*" /label="yoaM CDS" gene 1787252..1787935 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /label="yoaM gene" CDS complement(1788276..1788581) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative permease, phage-related; defective prophage 6" /protein_id="YP_003097734.1" /db_xref="EnsemblGenomes-Gn:BSU18669" /db_xref="EnsemblGenomes-Tr:CAX52628" /db_xref="GOA:C0H420" /db_xref="UniProtKB/Swiss-Prot:C0H420" /translation="MKALIFLSSLTAIGSSILGRWLGMLDDSYAVGDAWFIGVLAGLI SLLILIDSQTMTKNYIVSLSTILGILGVGFIYFPAAFINILLSITLDKQKKEDLHVR* " /label="yozS CDS" gene complement(1788276..1788581) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /label="yozS gene" S_feature complement(1788582..1788683) /Source="Nicolas_S_feature" /locus_tag="new_2037369_2037470_c" /HighExp="HiTm, LBGstat, LBGtran, T1.30H, T1.0H, T0.30H, M9-stat, Lbstat, M0t90, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S697" promotor_-10 complement(1788662..1788681) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1788683) /Source="Nicolas_upshifts" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1788696..1788703) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1788711..1788813) /Source="Nicolas_S_feature" /locus_tag="new_2037498_2037600_c" /HighExp="S8, S6, S7, S5, BT, G/S, Pyr, B36, nit, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S698" downshifts complement(1788753) /Source="Nicolas_upshifts" /id="D1024" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="1.67639" /MaxDrop="3.95763" /score="-5.39979801" /energy="-8.3" /TU="NA" /idTUdmin="U1514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1788814..1789992) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11546787, 14697267, 14973022, 15628860, 25526893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11546787, 14697267, 14973022, 15628860, 25526893; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase (Mn2+-dependent); spore constituent" /protein_id="NP_389748.1" /db_xref="EnsemblGenomes-Gn:BSU18670" /db_xref="EnsemblGenomes-Tr:CAB13759" /db_xref="GOA:O34767" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="SubtiList:BG13484" /db_xref="UniProtKB/Swiss-Prot:O34767" /translation="MLLEQQPINHEDRNVPQPIRSDGAGAIDTGPRNIIRDIQNPNIF VPPVTDEGMIPNLRFSFSDAPMKLDHGGWSREITVRQLPISTAIAGVNMSLTAGGVRE LHWHKQAEWAYMLLGRARITAVDQDGRNFIADVGPGDLWYFPAGIPHSIQGLEHCEFL LVFDDGNFSEFSTLTISDWLAHTPKDVLSANFGVPENAFNSLPSEQVYIYQGNVPGSV ASEDIQSPYGKVPMTFKHELLNQPPIQMPGGSVRIVDSSNFPISKTIAAALVQIEPGA MRELHWHPNSDEWQYYLTGQGRMTVFIGNGTARTFDYRAGDVGYVPSNAGHYIQNTGT ETLWFLEMFKSNRYADVSLNQWMALTPKELVQSNLNAGSVMLDSLRKKKVPVVKYPGT *" /label="oxdD CDS" gene complement(1788814..1789992) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /label="oxdD gene" promotor_-10 complement(1790018..1790037) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1790037) /Source="Nicolas_upshifts" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1790051..1790060) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1790115..1790603) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389749.1" /db_xref="EnsemblGenomes-Gn:BSU18680" /db_xref="EnsemblGenomes-Tr:CAB13760" /db_xref="InterPro:IPR032545" /db_xref="SubtiList:BG13485" /db_xref="UniProtKB/Swiss-Prot:O34985" /translation="MRKKNNIKKWLLIIAGFLIICIITLFVMVSGNKVKYEGSGKSGL WMSNLEKSDKTSIGPNYFLNLYWQGSKKEEKWTVVERITLYVDGEKYQDDNVDEYDLS EYTGDEMPGGGRMEDHISTFDYMPEDEVIGHDVLVKVEWRTGQKKQTEAIKLHKKPWY KK*" /label="yoaO CDS" gene complement(1790115..1790603) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /label="yoaO gene" downshifts complement(1790140) /Source="Nicolas_upshifts" /id="D1025" /incds=0 /nref=32 /ntot=201 /MaxReadThrough="0.50319" /MaxDrop="3.84714" /score="18.561323" /energy="-9.2" /TU="NA" /idTUdmin="U1514" /TUdmin="-1387" /isTUend="FALSE" /label="downshifts" CDS complement(1790628..1790783) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513964.1" /translation="MKQKMHLRAVIRFNLVFRKHFNLSQKFRQSSVRSLALSYFLFGN ILIVFSY*" /label="hypothetical protein CDS" gene complement(1790628..1790783) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /label="gene" CDS complement(1790823..1791578) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389750.1" /db_xref="EnsemblGenomes-Gn:BSU18690" /db_xref="EnsemblGenomes-Tr:CAB13761" /db_xref="GOA:O34983" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR025685" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13486" /db_xref="UniProtKB/Swiss-Prot:O34983" /translation="MCYIEITKDNIEDNHICCALSTKQYEHAVNEKKRWLKARMDEGL VFYRLHERAKVFIEYLPANEAWVPINAPNFMYINCLWVSGRYKNNGHAKRLLDKCIAD AKACGMDGIIHIAGKKKLPYLSDKHFFEHMGFTLQDEAAPYFQLMALTWNGLADSPAF KSQVKSDSINEKGITIYYTAQCPFAVGMINDLRELTEKKGVQFQSIQLSSKEEAQKSP AIWTTFSVFFDGRFVTHEIMSINKFEKLLNTLA*" /label="yoaP CDS" gene complement(1790823..1791578) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /label="yoaP gene" promotor_-35 1791831..1791836 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1791852..1791870 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1791867 /Source="Nicolas_upshifts" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="upshifts" CDS 1791886..1792242 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389751.1" /db_xref="EnsemblGenomes-Gn:BSU18700" /db_xref="EnsemblGenomes-Tr:CAB13762" /db_xref="SubtiList:BG13487" /db_xref="UniProtKB/Swiss-Prot:O31831" /translation="MVEKCYSCLICGYKGLIQNPLYKGEYQKTFDICPCCGFEFGYSE DHDVRLGFIVTPDHLIEAAFQLYRKQWLESGMVIAHPEDIPEELKNGNCLKFEVLLKQ LKKLNLDIENFEISGF*" /label="yoaQ CDS" gene 1791886..1792242 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /label="yoaQ gene" CDS complement(1792201..1792440) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (putative phage origin); putative defective prophage 6" /protein_id="YP_003097735.1" /db_xref="EnsemblGenomes-Gn:BSU18709" /db_xref="EnsemblGenomes-Tr:CAX52629" /db_xref="UniProtKB/Swiss-Prot:C0H421" /translation="MTVINDYREEPEEAFWILYPMGVKCLSMITKSLLNTNRDFVTDC AFQLNILLIMTVKPKQVQPVSSLKTANFKIFYVKI*" /label="yozT CDS" gene complement(1792201..1792440) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /label="yozT gene" S_feature 1792243..1792679 /Source="Nicolas_S_feature" /locus_tag="new_2041030_2041466" /HighExp="S8, S7, S4, S5, S6, S3, T5.0H, LoTm, BT, T4.0H" /AntisenseName="yozT" /AntisenseCor="0.93420248567111996" /AntisenseRegPval="-120.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S699" S_feature complement(1792441..1792542) /Source="Nicolas_S_feature" /locus_tag="new_2041228_2041329_c" /HighExp="S8, S7, S6, S5, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S700" CDS complement(1792543..1793040) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389752.2" /db_xref="EnsemblGenomes-Gn:BSU18710" /db_xref="EnsemblGenomes-Tr:CAB13763" /db_xref="SubtiList:BG13753" /db_xref="UniProtKB/Swiss-Prot:O31832" /translation="MKRVLFSVIVFTAVGFTFCQSKAHALTFTVLPITQKTDQWSVKV SEAKNVKEFTRPHKGEYQVYSLEVKNIGEKAATVDVQLYRNDPNSITRFSLFGCPDEN CVKPKEDSKMLAESLNDGSPLKFNHFMLADKASELEVVIIWTQKGQEGRNLKQTFKFT EDGVN*" /label="yozF CDS" gene complement(1792543..1793040) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /label="yozF gene" S_feature complement(1793041..1793140) /Source="Nicolas_S_feature" /locus_tag="new_2041828_2041927_c" /HighExp="S8, S7, S5, S6, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S701" CDS complement(1793141..1794052) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8631706; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor for cell wall maintenance or synthesis" /protein_id="NP_389753.1" /db_xref="EnsemblGenomes-Gn:BSU18720" /db_xref="EnsemblGenomes-Tr:CAB13764" /db_xref="InterPro:IPR007391" /db_xref="SubtiList:BG13488" /db_xref="UniProtKB/Swiss-Prot:O34611" /translation="MIQILITGLFLLAQPSEPQDSLTVTQQGRTIATVNREDFTMPLP GTPMVDYEKYSKFIKQLDQKVYREPINAVLNDHGSIVPGRVGYKLYQQAFMEKFYAYF YGQGPSKIEVPEMNIYPKVDSELLAHISTQQLGQYVTYFNSSNKSRSHNISLSAKAID NHVVFPNETFSFNQVVGMRTRNKGYKSAPIIVKGELSEGVGGGICQVSSTLFNAVDRA GLQIVQRYSHTRSVPYVPPGRDATVSWGGPDFRFQNQYNQPILIRAKRYGGSMIITLY SSDVINSRLRKIPKAPSRIPKEINAEQ*" /label="yoaR CDS" gene complement(1793141..1794052) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /label="yoaR gene" promotor_-10 complement(1794074..1794085) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1794076) /Source="Nicolas_upshifts" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1794100..1794106) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1794336..1794343 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1794352 /Source="Nicolas_upshifts" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1794358..1794377 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1794399..1794881 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19493340; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin / antitoxin system" /protein_id="NP_389754.1" /db_xref="EnsemblGenomes-Gn:BSU18730" /db_xref="EnsemblGenomes-Tr:CAB13765" /db_xref="GOA:O31833" /db_xref="InterPro:IPR021354" /db_xref="SubtiList:BG13489" /db_xref="UniProtKB/Swiss-Prot:O31833" /translation="MNRMSTIFLKIALVLIGIPILALCIFLVPKVANYSAELFPNIAY IKYLVFIYLYVTAIPFYFALYQAFKLLSYIDKNKAFSGLSVRALKNIKYCAVTISIFY AAGMPVFYLMAEIDDAPGIIVIGLVIIFASMVIAVFAAVLQKLLKEAIDIKSENDLTV *" /label="yoaS CDS" gene 1794399..1794881 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /label="yoaS gene" CDS 1794891..1795145 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19493340; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin of a toxin / antitoxin system; putative transcriptional regulator" /protein_id="NP_389755.1" /db_xref="EnsemblGenomes-Gn:BSU18740" /db_xref="EnsemblGenomes-Tr:CAB13766" /db_xref="GOA:O31834" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG13754" /db_xref="UniProtKB/Swiss-Prot:O31834" /translation="MAIIINIDVMLAKRKMSVTELSERVGITMANLSILKNGKAKAIR LSTLEAICKALECQPGDILEYRSDEDTGFVKKKYEGSTEK*" /label="yozG CDS" gene 1794891..1795145 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /label="yozG gene" S_feature 1795146..1795250 /Source="Nicolas_S_feature" /locus_tag="new_2043933_2044037" /HighExp="LoTm, B60, Sw, G135, G180, B36, LBGstat, Cold, LBGtran, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S702" CDS 1795251..1796045 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389756.1" /db_xref="EnsemblGenomes-Gn:BSU18750" /db_xref="EnsemblGenomes-Tr:CAB13767" /db_xref="GOA:O34535" /db_xref="InterPro:IPR008535" /db_xref="SubtiList:BG13490" /db_xref="UniProtKB/Swiss-Prot:O34535" /translation="MRAIKQIVHFGWEQALSCLFPAVIFASLAITQIIPLPFLPRYDW LLIICVLMQLWMVRSGLETRDELKVITLFHLIGLALELFKVHMGSWSYPEEGYSKIFG VPLYSGFMYASVASYLCQAWRRLKVELVKWPSFFAVVPLAAAIYLNFFTHHFSIDIRW WLSGLVIIVFWQTWVTYEVNGARYRMPLALSFILIGFFIWIAENIATFFGAWKYPNQI DTWSLVHLGKVSSWLLLVIVSFLIVASLKQVKEQSPTKAEMDESFS*" /label="yoaT CDS" gene 1795251..1796045 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /label="yoaT gene" S_feature 1796046..1797056 /Source="Nicolas_S_feature" /locus_tag="new_2044833_2045843" /HighExp="LoTm, Cold, Sw, H2O2, B60, GM 10, S8, dia15, T2.30H, MG 60" /AntisenseName="yoaU" /AntisenseCor="-2.6976304882719598E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S703" CDS complement(1796169..1797041) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_389757.1" /db_xref="EnsemblGenomes-Gn:BSU18760" /db_xref="EnsemblGenomes-Tr:CAB13768" /db_xref="GOA:O34701" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13491" /db_xref="UniProtKB/Swiss-Prot:O34701" /translation="MVMNMNHLHIFVKVGEKLNITEAAKELFISQPAVSKAIKNLESS LQLKLLIRDKHHGLMLTDIGKEILLLARQMKGIESKIYQVANRENKLLNGKVKIGSFP AVSTNIMPQAIAAFRSNYPLIRIELIEGTSDQIKGWVEDRTVDIGIAASPFEPFENQL LCNDYMVAVIPPQRDELKLEKHVDLETYQDDLIFCKGGHEIAMSNAFSQYNIELKENL TVQNAETLINMVKNNLGIGIISNFTLSSVPHQLIKKDIFPRVTRDIGVIAHSFEEITP AAHEFVKVLKAVVI*" /label="yoaU CDS" gene complement(1796169..1797041) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /label="yoaU gene" CDS 1797142..1798020 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10844694, 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative modified amino acid or TCA compound efflux permease" /protein_id="NP_389758.1" /db_xref="EnsemblGenomes-Gn:BSU18770" /db_xref="EnsemblGenomes-Tr:CAB13769" /db_xref="GOA:O34416" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG13492" /db_xref="UniProtKB/Swiss-Prot:O34416" /translation="MVKVMLGIISVTLIWGYTWVAMKVGIHDIPPLLFSGLRLFIGAV PLFLILFIQRKKLSIQKEHLKSYIIMSLLMGLGYMGILTYGMQFVDSGKTSVLVYTMP IFVTVISHFSLNEKMNVYKTMGLVCGLFGLLFIFGKEMLNIDQSALFGELCVLVAALS WGIANVFSKLQFKHIDIIHMNAWHLMMGAVMLLVFSFIFEAVPSAEWTYQAVWSLLFN GLLSTGFTFVVWFWVLNQIQASKASMALMFVPVLALFFGWLQLHEQITINIILGALLI CCGIFMNTFTFSRRKV*" /label="yoaV CDS" gene 1797142..1798020 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /label="yoaV gene" S_feature complement(1798133..1798192) /Source="Nicolas_S_feature" /locus_tag="new_2046920_2046979_c" /HighExp="BC, T4.0H, M9-stat, S5, T5.0H, S4, S3, T3.0H, T3.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.167154" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S704" downshifts complement(1798168) /Source="Nicolas_upshifts" /id="D1026" /incds=0 /nref=55 /ntot=175 /MaxReadThrough="1.78313" /MaxDrop="5.17096" /score="15.465237" /energy="-12.3" /TU="NA" /idTUdmin="U1518" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1798193..1798624) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm forming exported protein" /protein_id="NP_389759.1" /db_xref="EnsemblGenomes-Gn:BSU18780" /db_xref="EnsemblGenomes-Tr:CAB13770" /db_xref="SubtiList:BG13493" /db_xref="UniProtKB/Swiss-Prot:O34541" /translation="MKKMLMLAFTFLLALTIHVGEASAVIVKDEEKVSFTMTENEKWF MKSDDLNSNHWTSHFGYRFTIFDTEGCTINARIMRMTLSGYEITVSEKNFSGDHFDFS ATDRVETMPYKTHYLILTKDPDCGDVKVKGLYGFQFDQPEW*" /label="yoaW CDS" gene complement(1798193..1798624) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /label="yoaW gene" promotor_-10 complement(1798644..1798663) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1798652) /Source="Nicolas_upshifts" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1798654..1798887) /Source="Nicolas_S_feature" /locus_tag="new_2047441_2047674_c" /HighExp="S4, S3, S5, S7, S8, S6, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S705" promotor_-35 complement(1798677..1798683) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1798888..1798906) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1798888..1799520) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16181642; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor of the oxidative stress response" /protein_id="NP_389760.1" /db_xref="EnsemblGenomes-Gn:BSU18790" /db_xref="EnsemblGenomes-Tr:CAB13771" /db_xref="GOA:O34947" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13494" /db_xref="UniProtKB/Swiss-Prot:O34947" /translation="MQTRKVYLYVFHTMSDWEYGYLIAELNSGRYFKQDAASLKVVTV GVNKEMITTLGGLSIKPDISLDECTLGSQDLIILPGGNTWGEDIHQPILKKVGDALKL GTTIAAICGATLGLANEGYLNSRKHTSNDLDYMNMVCPNYKGETFYEKGPAVSDENLV TASGIAPLEFAVEVLKKLDVFAPDTLRSWYKLNKTQKPEYFFELMNTINR*" /label="yoaZ CDS" gene complement(1798888..1799520) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /label="yoaZ gene" upshifts complement(1798894) /Source="Nicolas_upshifts" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1798922..1798927) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1799658..1799665 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1799680..1799699 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1799684 /Source="Nicolas_upshifts" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="upshifts" CDS 1799746..1800666 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /EC_number="3.5.2.6" /function="16.5: Explore" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7789815, 15187182, 16944130, 22211522, 25112476, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-lactamase precursor (putative hydrolase)" /protein_id="NP_389761.1" /db_xref="EnsemblGenomes-Gn:BSU18800" /db_xref="EnsemblGenomes-Tr:CAB13772" /db_xref="GOA:P39824" /db_xref="InterPro:IPR000871" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023650" /db_xref="SubtiList:BG11016" /db_xref="UniProtKB/Swiss-Prot:P39824" /translation="MKLKTKASIKFGICVGLLCLSITGFTPFFNSTHAEAKSIEDTNM ASCITNKKFVQLEKKFDARLGVYAIDIGSNKTIAYRPNERFAYASTYKVLAAAAVLKK NSIEKLNEVIHYSKDDLVTYSPITEKHLDTGMSLKEISEAAIRYSDNTAGNILLQQLG GPKGFEKSLKQIGDHVTKAKRFETDLNSAIPGDIRDTSTAKALATDLKAFTLDNTLTT DKRMILTDWMRGNATGDELIRAGAPIGWEVGDKSGAGSYGTRNDIAIVWPPNRAPIVV AILSNRFTKDANYDNALIAEAAKVVLNDLK*" /label="penP CDS" gene 1799746..1800666 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /label="penP gene" promotor_-10 complement(1800177..1800196) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1800192) /Source="Nicolas_upshifts" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1800211..1800218) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1800667..1801324 /Source="Nicolas_S_feature" /locus_tag="new_2049454_2050111" /HighExp="HiOs, S8, GM 25, GM 15, GM-0.1, C30, S2, S1, BC, GM 45" /AntisenseName="yobA" /AntisenseCor="8.9918765131424994E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S706" CDS complement(1801163..1801525) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389762.1" /db_xref="EnsemblGenomes-Gn:BSU18810" /db_xref="EnsemblGenomes-Tr:CAB13773" /db_xref="InterPro:IPR021598" /db_xref="PDB:2JQO" /db_xref="PDB:4QY7" /db_xref="SubtiList:BG13495" /db_xref="UniProtKB/Swiss-Prot:O31835" /translation="MPKIGVSLIVLIMLIIFLAGCNKNEQNGDETKMQSLVGYVVLKD NERAILITDTKAPGKEDYNLSEGQLMNKFKNNIVIVGLSEIDNTDDLKRGEKIKVWFH TRKESNPPSATIQKYELL*" /label="yobA CDS" gene complement(1801163..1801525) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /label="yobA gene" CDS complement(1801586..1801798) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage protein" /db_xref="PSEUDO:CAX52630.1" /translation="MEVAIVNDSKDKYIYAGIQKEAAFNNIFESAKMSKRIISRATTC KYLRKNKKKVEELENEYAAVMNCKKK*" /label="yozU CDS" gene complement(1801586..1801798) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /pseudo /label="yozU gene" promotor_-35 1801837..1801844 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1801859..1801878 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1801862 /Source="Nicolas_upshifts" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="upshifts" CDS 1801902..1802165 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376821; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator from bacteriophage; putative defective prophage 6" /protein_id="NP_389763.1" /db_xref="EnsemblGenomes-Gn:BSU18820" /db_xref="EnsemblGenomes-Tr:CAB13774" /db_xref="SubtiList:BG13496" /db_xref="UniProtKB/Swiss-Prot:O31836" /translation="MKIRKILLSSALSFGMLISAVPALAAGTSSEVAVKNEEYDYDTI YRISPLPMDFQPTIEYNGYTYTLTRHYFDYSIGFYTAIYTKVV*" /label="yobB CDS" gene 1801902..1802165 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /label="yobB gene" downshifts 1802143 /Source="Nicolas_upshifts" /id="D1027" /incds=0 /nref=23 /ntot=100 /MaxReadThrough="0.60454" /MaxDrop="4.81085" /score="19.5390064" /energy="-8.7" /TU="NA" /idTUdmin="U1522" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(1802542..1805142) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /EC_number="2.7.9.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PEP-dependent enzyme" /protein_id="NP_389764.1" /db_xref="EnsemblGenomes-Gn:BSU18830" /db_xref="EnsemblGenomes-Tr:CAB13775" /db_xref="GOA:O34309" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG12657" /db_xref="UniProtKB/Swiss-Prot:O34309" /translation="MSSLVLGLHEIEKTQLSLVGGKGLHLGELSKIQGIQVPEGFCVT TVGYQKAIEQNETLQVLLDQLTMLKVEDRDQIGNISRKIRQIIMEVDIPSDVVKAVAQ YLSQFGEEHAYAVRSSATAEDLPHASFAGQQDTYLNITGVDAILQHISKCWASLFTDR AVIYRMQNGFDHSQVYLSVIVQRMVFPQASGILFTADPITSNRKVLSIDAGFGLGEAL VSGLVSADCFKVQDGQIIDKRIATKKMAIYGRKEGGTETQQIDSDQQKAQTLTDEQIL QLARIGRQIEAHFGQPQDIEWCLARDTFYIVQSRPITTLFPIPEASDQENHVYISVGH QQMMTDPIKPLGLSFFLLTTVAPMRKAGGRLFVDVTHHLASPDSREVFLKGMGQHDQL LKDALMTIIKRRDFIKSIPNDKTAPNPSRGNADMPAQVENDPTIVSDLIESSQTSIEE LKQNIQTKSGSDLFRFILEDIQELKKILFNPKSSVLIRTAMNASLWINEKMNEWLGEK NAADTLSQSVPHNITSEMGLALLDVADVIRPYPEVIDYLQHVKDDNFLDELAKFDGGS KTRDAIYDYLSKYGMRCTGEIDITRTRWSEKPTTLVPMILNNIKNFEPNVGHRKFEQG RQEALKKEQELLDRLKQLPDGEQKAKETKRAIDIIRNFSGFREYPKYGMVNRYFVYKQ ALLKEAEQLIEAGVIHEKEDIYYLTFEELHEVVRTHKLDYQIISTRKDEYTLYEKLSP PRVITSDGEIVTGEYKRENLPAGAIVGLPVSSGVIEGRARVILNMEDADLEDGDILVT SFTDPSWTPLFVSIKGLVTEVGGLMTHGAVIAREYGLPAVVGVENAAKLIKDGQRIRV HGTEGYIEIF*" /label="yppS CDS" gene complement(1802542..1805142) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /label="yppS gene" S_feature complement(1805143..1805252) /Source="Nicolas_S_feature" /locus_tag="new_2053930_2054039_c" /HighExp="dia15, BC, S6, SMMPr, H2O2, S5, T-5.40H, S4, HPh, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S707" promotor_-35 1805168..1805175 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1805190..1805209 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1805198..1805825 /Source="Nicolas_S_feature" /locus_tag="new_2053985_2054612" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, S1, T2.30H, Heat, S2, T-5.40H, C30" /AntisenseName="xynA" /AntisenseCor="-0.30871986344497798" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S708" upshifts 1805198 /Source="Nicolas_upshifts" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1805242..1805261) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1805252) /Source="Nicolas_upshifts" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1805276..1805282) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1805298..1805757) /Source="Nicolas_S_feature" /locus_tag="new_2054085_2054544_c" /HighExp="S0, Lbstat, HiTm, dia0, ferm, Lbexp, T1.0H, M0t45, LBGtran, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S709" downshifts complement(1805340) /Source="Nicolas_upshifts" /id="D1028" /incds=0 /nref=87 /ntot=200 /MaxReadThrough="1.89557" /MaxDrop="5.26144" /score="1.97345986" /energy="-10.4" /TU="NA" /idTUdmin="U1525" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1805802) /Source="Nicolas_upshifts" /id="D1029" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="5.28207" /MaxDrop="3.16026" /score="1.97345986" /energy="-10.4" /TU="U1525" /idTUdmin="U1525" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(1805812..1806453) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /EC_number="3.2.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7704256, 8628241, 16517552, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704256, 8628241, 16517552, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-1,4-beta-xylanase" /protein_id="NP_389765.1" /db_xref="EnsemblGenomes-Gn:BSU18840" /db_xref="EnsemblGenomes-Tr:CAB13776" /db_xref="GOA:P18429" /db_xref="InterPro:IPR001137" /db_xref="InterPro:IPR013319" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018208" /db_xref="InterPro:IPR033119" /db_xref="InterPro:IPR033123" /db_xref="PDB:1AXK" /db_xref="PDB:1XXN" /db_xref="PDB:2B42" /db_xref="PDB:2B45" /db_xref="PDB:2B46" /db_xref="PDB:2DCY" /db_xref="PDB:2DCZ" /db_xref="PDB:2QZ3" /db_xref="PDB:2Z79" /db_xref="PDB:3EXU" /db_xref="PDB:3HD8" /db_xref="PDB:5K9Y" /db_xref="SubtiList:BG10808" /db_xref="UniProtKB/Swiss-Prot:P18429" /translation="MFKFKKNFLVGLSAALMSISLFSATASAASTDYWQNWTDGGGIV NAVNGSGGNYSVNWSNTGNFVVGKGWTTGSPFRTINYNAGVWAPNGNGYLTLYGWTRS PLIEYYVVDSWGTYRPTGTYKGTVKSDGGTYDIYTTTRYNAPSIDGDRTTFTQYWSVR QSKRPTGSNATITFSNHVNAWKSHGMNLGSNWAYQVMATEGYQSSGSSNVTVW*" /label="xynA CDS" gene complement(1805812..1806453) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /label="xynA gene" S_feature complement(1806454..1806571) /Source="Nicolas_S_feature" /locus_tag="new_2055241_2055358_c" /HighExp="S0, HiTm, T1.0H, Gly, Lbstat, SMMPr, Lbtran, LBGstat, SMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S710" promotor_-10 complement(1806548..1806567) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1806571) /Source="Nicolas_upshifts" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1806581..1806583) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(1806659,1806666) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs05" N_region 1806660..1806665 /note="SacI site (GAGCTC)" /modified_by="User" /label="IIG_Bs05" misc_RNA <1806666..1806750 /gene="bsrF" /locus_tag="BSU_misc_RNA_75" /product="small untranslated regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 19542274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 19542274; Product type n: RNA" /label="bsrF RNA" S_feature <1806666..1806743 /Source="Nicolas_S_feature" /locus_tag="new_2079086_2079196" /HighExp="LoTm, S7, HPh, LPhT, S8, BT, S6, G/S, S0, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.896, 1" /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S728" S_feature complement(<1806666..1806730) /Source="Nicolas_S_feature" /locus_tag="new_2078548_2079183_c" /HighExp="MG 150, S8, MG 120, S7, MG 90, GM-0.1, Glu, Fru, GM-0.2, GM 5" /AntisenseName="yobO" /AntisenseCor="0.134597835896198" /AntisenseRegPval="-1.6" /CDS_PredictionProba="0.40121099999999998" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S726" gene <1806666..1806750 /gene="bsrF" /old_locus_tag="BSU_misc_RNA_75" /locus_tag="PG10_pseudo_BSU_misc_RNA_75" /modified_by="User" /label="PG10_pseudo_BSU_misc_RNA_75" downshifts 1806728 /Source="Nicolas_upshifts" /id="D1044" /incds=0 /nref=65 /ntot=254 /MaxReadThrough="1.60135" /MaxDrop="9.06442" /score="30.7999406" /energy="-13.9" /TU="NA" /idTUdmin="U1545" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1806761..1807093) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /function="16.1: Circulate" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10658654, 10816431, 13129613, 15856219, 17372352, 28724440; Product type f : factor" /codon_start=1 /transl_table=11 /product="molecular chaperone for secreting proteins" /protein_id="NP_389785.1" /db_xref="EnsemblGenomes-Gn:BSU19040" /db_xref="EnsemblGenomes-Tr:CAB13796" /db_xref="GOA:P37584" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR008231" /db_xref="InterPro:IPR012340" /db_xref="PDB:2NZH" /db_xref="PDB:2NZO" /db_xref="SubtiList:BG10809" /db_xref="UniProtKB/Swiss-Prot:P37584" /translation="MAVIDDFEKLDIRTGTIVKAEEFPEARVPAIKLVIDFGTEIGIK QSSAQITKRYKPEGLINKQVIAVVNFPPRRIAGFKSEVLVLGGIPGQGDVVLLQPDQP VPNGTKIG*" /label="csaA CDS" gene complement(1806761..1807093) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /label="csaA gene" downshifts complement(1806775) /Source="Nicolas_upshifts" /id="D1045" /incds=0 /nref=28 /ntot=228 /MaxReadThrough="4.42209" /MaxDrop="5.706" /score="-8.98970984" /energy="-13.9" /TU="U1547" /idTUdmin="U1550" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1807158..1807883) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478, 27038276; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_389786.1" /db_xref="EnsemblGenomes-Gn:BSU19050" /db_xref="EnsemblGenomes-Tr:CAB13797" /db_xref="GOA:O34901" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG13508" /db_xref="UniProtKB/Swiss-Prot:O34901" /translation="MLMDSLQEIICEKRTYTRLYHSHKHAYSQFLFPLEGSIDLETEG RQVKLNPDHFLYIPPQCEHRFRSIGRNECLVLDVPLHAMKIDEYRAGSGIEAALDPFW SSIRYLLTEEAKAGTANSLHMLVQYIKEKLQSHSYASIAYIHSHLFERLTIKKLAEIE HYHPAYYSSWFKKQTGKSPQNYIADLRLEEAKRMLMERNETLTVVSEALGFQNLSSFT RWFTKSTGMPPRLYRNTLYSDKK*" /label="yobQ CDS" gene complement(1807158..1807883) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /label="yobQ gene" CDS complement(1807898..1808641) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389787.1" /db_xref="EnsemblGenomes-Gn:BSU19060" /db_xref="EnsemblGenomes-Tr:CAB13798" /db_xref="GOA:O34376" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13509" /db_xref="UniProtKB/Swiss-Prot:O34376" /translation="MDDIRKIERLAAASWPAYFQKSIGKWLLRANFGVTKRANSVWTS ADMPEGDFQLEAELFYQSLGLPVCFHISNASPKGLDDALADSRYEKVDECFQMTALCR SIMSRTNDNSRFTYKWEQEPSSVWIDEFIQLEGFSPERHKGYKHIFERMPPCKTFFKM YDKESLTALGTVSVIDGYGGLSNIVVAEEHRGKGAGTQVIRVLTEWAKNNGAERMFLQ VMKENLAAVSLYGKIGFSPISEHHYRIKR*" /label="yobR CDS" gene complement(1807898..1808641) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /label="yobR gene" promotor_-10 complement(1808669..1808688) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1808688) /Source="Nicolas_upshifts" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1808702..1808708) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1808719..1809294) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389788.1" /db_xref="EnsemblGenomes-Gn:BSU19070" /db_xref="EnsemblGenomes-Tr:CAB13799" /db_xref="GOA:O34892" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025996" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG13510" /db_xref="UniProtKB/Swiss-Prot:O34892" /translation="MSPRIGLTQKMIVDAAAEIADQEGVNGVSLAALSKKMNVRPPSL YNHINGLQAIRAELAVRGLTKLFDQMADSVTERKGDSAMLSLAHAYVDFAIENPGYYE AALLKVHDKRTEIVSDQIVCLVTKLLIENGYASEKTAIHATRGLRSLLHGFTVLIAKE AFEREEDILESLSFSIRTFLSGLLINNKNIM*" /label="yobS CDS" gene complement(1808719..1809294) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /label="yobS gene" CDS complement(1809300..1810001) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_389789.1" /db_xref="EnsemblGenomes-Gn:BSU19080" /db_xref="EnsemblGenomes-Tr:CAB13800" /db_xref="GOA:O34910" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13511" /db_xref="UniProtKB/Swiss-Prot:O34910" /translation="MRITQYQTVWQLTFFPALFPVNCYLVEEENEVTLIDAALPGSYK GIIQAVNQLGKPLQHILLTHAHGDHVGSLDTLAQTFPHAKVMISERDSFLLQGDTSLR QDEPQTPIKGGIPKHIQTKPHQLLTGGETIGSLLAIPTPGHTPGSMSFLDTRNGTLIA GDAFQLRGGIAVSGQIKWAFPFPAFATWNKEEAIKSAQLLADKAPSCLAVGHGKFLRS PSERMRQAIQKAKKG*" /label="yobT CDS" gene complement(1809300..1810001) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /label="yobT gene" promotor_-10 complement(1810031..1810050) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1810031) /Source="Nicolas_upshifts" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1810035..1810050) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1810065..1810072) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1810065..1810072) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1810075) /Source="Nicolas_upshifts" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1810078..1810560) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative effector of transcriptional regulator" /protein_id="NP_389790.1" /db_xref="EnsemblGenomes-Gn:BSU19090" /db_xref="EnsemblGenomes-Tr:CAB13801" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG13512" /db_xref="UniProtKB/Swiss-Prot:O34637" /translation="MGFSHITHLDLKRFAGLSQRTSNALEMTEERRIPALWDQLWKQD MSALLSQAEKDKSIIALYSNYEQETNGFYTFSVGTFQEYDDILPGPYENIDLPASAYA VFTSRIGPIEEIVLETWKEIWTWDKRHLRTFTGDFEMYDQNAAVPQRAQVNIYVAIKK *" /label="yobU CDS" gene complement(1810078..1810560) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /label="yobU gene" misc_feature complement(1810599..1810616) /Source="Nicolas_upshift_promotors" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1810603) /Source="Nicolas_upshifts" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1810614..1811555) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389791.1" /db_xref="EnsemblGenomes-Gn:BSU19100" /db_xref="EnsemblGenomes-Tr:CAB13802" /db_xref="GOA:O34920" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026881" /db_xref="InterPro:IPR028349" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13513" /db_xref="UniProtKB/Swiss-Prot:O34920" /translation="MKLERLLAMVVLLISKKQVQAAELAELFEVSVRTIYRDIETINR AGIPIVTSQGSGGGIGIMETYRLEREWLKEEELFAIASALQSVSSMYEPVSHSTAYQK IKHLIPEQSTQAFKHQTEKWFIDMTAWGHTEDQKTLREKISAAIDRLLTISFTYTSAS GETLLRETEPYTLVCKAGHWYLYAYCLVRNDFRFFKLNRMKDLAILHQTFIRKDIQLD TLPWDKSWYQKDRLTELVILVQPSARQRIGEWFGYDVLHCCEEDEICQAVISLPEDQW LIGFLLQFGKDIEVLQPLHIRDKVKETIHHMQKIYET*" /label="yobV CDS" gene complement(1810614..1811555) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /label="yobV gene" downshifts complement(1810647) /Source="Nicolas_upshifts" /id="D1046" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="0.95712" /MaxDrop="3.62763" /score="-3.71616684" /energy="-9" /TU="NA" /idTUdmin="U1548" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1811585..1811604) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1811593) /Source="Nicolas_upshifts" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1811618..1811622) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1811626..1811635 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1811648..1811667 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1811656 /Source="Nicolas_upshifts" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="upshifts" S_feature 1811671..1811735 /Source="Nicolas_S_feature" /locus_tag="new_2084124_2084188" /HighExp="BT, S7, B36, S8, S6, Pyr, G/S, B60, Glucon, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S729" promotor_-35 1811707..1811712 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1811728..1811746 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1811737 /Source="Nicolas_upshifts" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="upshifts" CDS 1811761..1812306 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8990290, 11717295, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 11717295, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="mother cell-specific membrane sporulation protein" /protein_id="NP_389792.1" /db_xref="EnsemblGenomes-Gn:BSU19110" /db_xref="EnsemblGenomes-Tr:CAB13803" /db_xref="GOA:P94497" /db_xref="InterPro:IPR014743" /db_xref="SubtiList:BG12269" /db_xref="UniProtKB/Swiss-Prot:P94497" /translation="MHLTLQSVYPAIIIIFFLYKKIKRSIGYQPLKPRWLFTRIILFS LFAFGLSIFSAIHPFLYGYLILGILGGWLLVFFAKKNISFEKRRGKIYFRTHIWVEVI LLTLFLSRFLYRVTELYLTSPDLNRLGSYSQSIGTDPLTIGVCFLIAVYYIGFSSFII KLSRNELEQHEYNKEKDILAR*" /label="yobW CDS" gene 1811761..1812306 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /label="yobW gene" downshifts 1812265 /Source="Nicolas_upshifts" /id="D1047" /incds=0 /nref=20 /ntot=63 /MaxReadThrough="3.56215" /MaxDrop="4.5413" /score="-4.21976438" /energy="-17.7" /TU="U1552,U1553" /idTUdmin="U1552" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" CDS complement(1812333..1812656) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15948947, 16406068, 16430705, 19170879, 19995076, 25213752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16406068, 16430705, 19170879, 19995076, 25213752; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (multiple metal-sensing ArsR-SmtB transcriptional repressor favouring Zn2+)" /protein_id="NP_389793.1" /db_xref="EnsemblGenomes-Gn:BSU19120" /db_xref="EnsemblGenomes-Tr:CAB13804" /db_xref="GOA:O31844" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13748" /db_xref="UniProtKB/Swiss-Prot:O31844" /translation="MTEFRETEQSAADLDEETLFLVAQTFKALSDPTRIRILHLLSQG EHAVNGIAEKLNLLQSTVSHQLRFLKNLRLVKSRREGTSIYYSPEDEHVLDVLQQMIH HTQHD*" /label="czrA CDS" gene complement(1812333..1812656) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /label="czrA gene" downshifts complement(1812340) /Source="Nicolas_upshifts" /id="D1048" /incds=0 /nref=73 /ntot=252 /MaxReadThrough="1.89304" /MaxDrop="4.873" /score="17.3750937" /energy="-18.6" /TU="NA" /idTUdmin="U1554" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1812677..1812696) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1812688) /Source="Nicolas_upshifts" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1812709..1812716) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1812777..1812783 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1812794 /Source="Nicolas_upshifts" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1812798..1812817 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1812850..1813527 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative murein fragments glycosidase" /protein_id="NP_389794.1" /db_xref="EnsemblGenomes-Gn:BSU19130" /db_xref="EnsemblGenomes-Tr:CAB13805" /db_xref="GOA:O34636" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13514" /db_xref="UniProtKB/Swiss-Prot:O34636" /translation="MKKKRKGCFAAAGFMMIFVFVIASFLLVLLFFNRDLIKKLPIDT KTIVLERLTDYKPLVEEELESQGLSNYTSLILGMMYQESKGKGNDPMQSSESLGLKRN EITDPQLSVKQGIKQFTLMYKTGKEKGVDLDTIIQSYNMGAGYIDFVAEHGGTHTEEL AKQYSEQQVKKNPDLYTCGGNAKNFRYPYCYGDYTYAEKVKEKTKTVEESLQVATLET MESKAHE*" /label="yocA CDS" gene 1812850..1813527 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /label="yocA gene" downshifts 1813519 /Source="Nicolas_upshifts" /id="D1049" /incds=0 /nref=207 /ntot=268 /MaxReadThrough="3.9729" /MaxDrop="8.52704" /score="-4.21976438" /energy="-17.7" /TU="U1555" /idTUdmin="U1555" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1813617..1814153) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19222757, 24214949; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389795.1" /db_xref="EnsemblGenomes-Gn:BSU19140" /db_xref="EnsemblGenomes-Tr:CAB13806" /db_xref="GOA:O31845" /db_xref="InterPro:IPR007352" /db_xref="InterPro:IPR013833" /db_xref="SubtiList:BG13749" /db_xref="UniProtKB/Swiss-Prot:O31845" /translation="MNQTENKPKNYTGIVLTLTVLINGLIAVLFFMPKLDQFSHANIH ILPMLNAIFNSFTFIFLLAALIMIKQKNIKAHKRFILAAFTTTLLFLICYVTYHSIAE NTLYGGEGIMRPIYFFILITHICLSAIIVPLALFTLIRGFSMQVERHKKIARWTMPLW LYVSLTGVIVYLMISPYY*" /label="yozB CDS" gene complement(1813617..1814153) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /label="yozB gene" downshifts complement(1813640) /Source="Nicolas_upshifts" /id="D1050" /incds=0 /nref=175 /ntot=250 /MaxReadThrough="4.33842" /MaxDrop="7.96098" /score="14.7470642" /energy="-7.7" /TU="U1556" /idTUdmin="U1557" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1814180..1814199) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1814200) /Source="Nicolas_upshifts" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1814213..1814220) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1814290..1815072) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389796.1" /db_xref="EnsemblGenomes-Gn:BSU19150" /db_xref="EnsemblGenomes-Tr:CAB13807" /db_xref="SubtiList:BG13515" /db_xref="UniProtKB/Swiss-Prot:O34516" /translation="MAIDSLINKLQYVQLEPPDKILSLYLNTDMRDPEQQGGEWKIAL KSGFSRLKEYLAASDPEEEKCLDGIRAKMNQYLNAMGKDMPRSLVFFVSDSGIWEPIK LQVPVDTRFYWEETAVLDQLKGLRQTYPSTAFILTQQHEVKIIETVLGKIEAVERYEY DMINESWKNSHSAVDKAPPFEENRMREHVTENQSRLYKRLAASLDQKAAAKRWERMVI AGDKETADILDQHMNKPIHSKIQKNLLNENEHKVIEHLIKEA*" /label="yocB CDS" gene complement(1814290..1815072) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /label="yocB gene" downshifts complement(1814299) /Source="Nicolas_upshifts" /id="D1051" /incds=0 /nref=3 /ntot=38 /MaxReadThrough="5.37496" /MaxDrop="4.00348" /score="14.7470642" /energy="-7.7" /TU="U1557" /idTUdmin="U1557" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1815094..1815112) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1815113) /Source="Nicolas_upshifts" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1815126..1815132) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1815169..1815176 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1815191..1815210 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1815195 /Source="Nicolas_upshifts" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="upshifts" CDS 1815243..1815740 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389797.1" /db_xref="EnsemblGenomes-Gn:BSU19160" /db_xref="EnsemblGenomes-Tr:CAB13808" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13516" /db_xref="UniProtKB/Swiss-Prot:O35042" /translation="MFTVKEKNRQELEEELNDLEFQIYRMQENMKDLSKDAKVLGIDQ SKHDEWMIVSSIDDGQTCKIMLTDCKTAYRGKGCFSLVASYKDDAIHIGDIKGPPNHG FGSICMKYLKDIARDHNIPKVTGDIAKRDWNHVDRLIHFYEKHHFKVCIDHDTQSGSI KWVDL*" /label="yocC CDS" gene 1815243..1815740 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /label="yocC gene" promotor_-35 1815747..1815750 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1815766..1815785 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1815768 /Source="Nicolas_upshifts" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="upshifts" CDS 1815804..1816781 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /EC_number="3.4.17.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22516613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxypeptidase; aminoacid adenylate hydrolase (microcin resistance)" /protein_id="NP_389798.1" /db_xref="EnsemblGenomes-Gn:BSU19170" /db_xref="EnsemblGenomes-Tr:CAB13809" /db_xref="GOA:O35046" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13517" /db_xref="UniProtKB/Swiss-Prot:O35046" /translation="MYASKLKKGDEIRIVSPATSMSILSNEAKIQAKTALERLGYRVT IAEHANECNEFDSSSIESRVHDLHAAFFDPGVKAILTTLGGFNSNQLLRYLDYEKIKR HPKILCGYSDITALCNAIYQKTGLVTYSGPHFSTFAMKKGLDYTEEYFLSCCASDDPF EIHPSSEWSDDRWFLDQENRRFYPNNGPVVIQEGYAEGTLIGGNLCTLNLLQGTEYFP ETEHTILLIEDDYMSDIHMFDRDLQSLIHLPAFSHVKAILIGRFQKASNVSIDLVKAM IETKKELSGIPIIANINAGHTSPIATFPIGGTCRIEAISGTSRIWIDKH*" /label="yocD CDS" gene 1815804..1816781 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /label="yocD gene" downshifts 1816753 /Source="Nicolas_upshifts" /id="D1052" /incds=0 /nref=131 /ntot=256 /MaxReadThrough="3.77491" /MaxDrop="4.2254" /score="1.66373432" /energy="-9.5" /TU="U1558,U1559" /idTUdmin="U1558" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-35 1816878..1816885 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1816900..1816919 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1816907 /Source="Nicolas_upshifts" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="upshifts" CDS 1816943..1818001 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /EC_number="1.14.19.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid desaturase" /protein_id="NP_389799.1" /db_xref="EnsemblGenomes-Gn:BSU19180" /db_xref="EnsemblGenomes-Tr:CAB13810" /db_xref="GOA:O34653" /db_xref="InterPro:IPR005804" /db_xref="SubtiList:BG13518" /db_xref="UniProtKB/Swiss-Prot:O34653" /translation="MTEQTIAHKQKQLTKQVAAFAQPETKNSLIQLLNTFIPFFGLWF LAYLSLDVSYLLTLALTVIAAGFLTRIFIIFHDCCHQSFFKQKRYNHILGFLTGVLTL FPYLQWQHSHSIHHATSSNLDKRGTGDIWMLTVNEYKAASRRTKLAYRLYRNPFIMFI LGPIYVFLITNRFNKKGARRKERVNTYLTNLAIVALAAACCLIFGWQSFLLVQGPIFL ISGSIGVWLFYVQHTFEDSYFEADENWSYVQAAVEGSSFYKLPKLLQWLTGNIGYHHV HHLSPKVPNYKLEVAHEHHEPLKNVPTITLKTSLQSLAFRLWDEDNKQFVSFRAIKHI PVSLPPDSPEKQKLRKNA*" /label="desE CDS" gene 1816943..1818001 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /label="desE gene" S_feature 1818002..1818071 /Source="Nicolas_S_feature" /locus_tag="new_2090455_2090524" /HighExp="Cold, S8, LoTm, Sw, Paraq, BC, S7, S0, Oxctl, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.859" /TUlongSig="SigA, SigA" /TUlongPSig="0.984, 1" /label="S730" promotor_-35 1818055..1818061 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1818073..1818092 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1818073 /Source="Nicolas_upshifts" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="upshifts" CDS 1818121..1819233 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component thermosensor histidine kinase [DesR-DesK]" /protein_id="NP_389800.1" /db_xref="EnsemblGenomes-Gn:BSU19190" /db_xref="EnsemblGenomes-Tr:CAB13811" /db_xref="GOA:O34757" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="PDB:3EHF" /db_xref="PDB:3EHG" /db_xref="PDB:3EHH" /db_xref="PDB:3EHJ" /db_xref="PDB:3GIE" /db_xref="PDB:3GIF" /db_xref="PDB:3GIG" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUM" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13519" /db_xref="UniProtKB/Swiss-Prot:O34757" /translation="MIKNHFTFQKLNGITPYIWTIFFILPFYFIWKSSSTFVIIVGII LTLLFFSVYRFAFVSKGWTIYLWGFLLIGISTASITLFSYIYFAFFIAYFIGNIKERV PFHILYYVHLISAAVAANFSLVLKKEFFLTQIPFVVITLISAILLPFSIKSRKERERL EEKLEDANERIAELVKLEERQRIARDLHDTLGQKLSLIGLKSDLARKLIYKDPEQAAR ELKSVQQTARTSLNEVRKIVSSMKGIRLKDELINIKQILEAADIMFIYEEEKWPENIS LLNENILSMCLKEAVTNVVKHSQAKTCRVDIQQLWKEVVITVSDDGTFKGEENSFSKG HGLLGMRERLEFANGSLHIDTENGTKLTMAIPNNSK*" /label="desK CDS" gene 1818121..1819233 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /label="desK gene" CDS 1819252..1819851 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [DesK]" /protein_id="NP_389801.1" /db_xref="EnsemblGenomes-Gn:BSU19200" /db_xref="EnsemblGenomes-Tr:CAB13812" /db_xref="GOA:O34723" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:4LDZ" /db_xref="PDB:4LE0" /db_xref="PDB:4LE1" /db_xref="PDB:4LE2" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13520" /db_xref="UniProtKB/Swiss-Prot:O34723" /translation="MISIFIAEDQQMLLGALGSLLNLEDDMEVVGKGTTGQDAVDFVK KRQPDVCIMDIEMPGKTGLEAAEELKDTGCKIIILTTFARPGYFQRAIKAGVKGYLLK DSPSEELANAIRSVMNGKRIYAPELMEDLYSEANPLTDREKEVLELVADGKNTKEIAQ ELSIKSGTVRNYISMILEKLEVKNRIEAITRSKEKGWFK*" /label="desR CDS" gene 1819252..1819851 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /label="desR gene" downshifts 1819789 /Source="Nicolas_upshifts" /id="D1053" /incds=1 /nref=1 /ntot=41 /MaxReadThrough="4.44811" /MaxDrop="2.78724" /score="23.648858" /energy="-15.4" /TU="U1560" /idTUdmin="U1560" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1819833 /Source="Nicolas_upshifts" /id="D1054" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.88273" /MaxDrop="3.38398" /score="23.648858" /energy="-15.4" /TU="NA" /idTUdmin="U1560" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1819873..1820371) /Source="Nicolas_S_feature" /locus_tag="new_2092326_2092824_c" /HighExp="S4, LoTm, S6, S3, S5, S8, S7, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.230296" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S731" downshifts complement(1819909) /Source="Nicolas_upshifts" /id="D1055" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.62146" /MaxDrop="5.61121" /score="23.7393309" /energy="-12.4" /TU="NA" /idTUdmin="U1563" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1820343..1820352 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1820355..1820373) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1820364..1820558 /Source="Nicolas_S_feature" /locus_tag="new_2092817_2093011" /HighExp="S6, S8, S7, BT, B36, Pyr, G/S, C30, S5, B60" /AntisenseName="yocH" /AntisenseCor="0.113870403460631" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S732" upshifts 1820364 /Source="Nicolas_upshifts" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1820365..1820384 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1820371) /Source="Nicolas_upshifts" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1820390..1820395) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1820446..1821309) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /EC_number="3.2.1.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:17307850, 20070526, 20487291, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17307850, 20070526, 20487291, 26102633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported cell wall lytic enzyme" /protein_id="NP_389802.1" /db_xref="EnsemblGenomes-Gn:BSU19210" /db_xref="EnsemblGenomes-Tr:CAB13813" /db_xref="GOA:O34669" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG13521" /db_xref="UniProtKB/Swiss-Prot:O34669" /translation="MKKTIMSFVAVAALSTTAFGAHASAKEITVQKGDTLWGISQKNG VNLKDLKEWNKLTSDKIIAGEKLTISSEETTTTGQYTIKAGDTLSKIAQKFGTTVNNL KVWNNLSSDMIYAGSTLSVKGQATAANTATENAQTNAPQAAPKQEAVQKEQPKQEAVQ QQPKQETKAEAETSVNTEEKAVQSNTNNQEASKELTVTATAYTANDGGISGVTATGID LNKNPNAKVIAVDPNVIPLGSKVYVEGYGEATAADTGGAIKGNKIDVFVPSKSDASNW GVKTVSVKVLN*" /label="walL CDS" gene complement(1820446..1821309) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /label="walL gene" downshifts complement(1820459) /Source="Nicolas_upshifts" /id="D1056" /incds=0 /nref=227 /ntot=262 /MaxReadThrough="2.55593" /MaxDrop="7.59881" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts 1820515 /Source="Nicolas_upshifts" /id="D1057" /incds=1 /nref=8 /ntot=28 /MaxReadThrough="6.14664" /MaxDrop="3.95582" /score="23.648858" /energy="-15.4" /TU="U1562" /idTUdmin="U1560" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(1820547) /Source="Nicolas_upshifts" /id="D1058" /incds=1 /nref=10 /ntot=161 /MaxReadThrough="7.34609" /MaxDrop="3.8459" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" S_feature 1820560..1821327 /Source="Nicolas_S_feature" /locus_tag="new_2093013_2093780" /HighExp="BT, S8, S6, Gly, S7, C30, G135, G/S, Fru, Pyr" /AntisenseName="yocH" /AntisenseCor="-0.12155468325348801" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S733" promotor_-35 1821305..1821309 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1821318..1821332 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1821329 /Source="Nicolas_upshifts" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1821348..1821367) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1821361) /Source="Nicolas_upshifts" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1821363..1821556) /Source="Nicolas_S_feature" /locus_tag="new_2093816_2094009_c" /HighExp="LoTm, HiOs, S8, C30, S2, G135, G180, T5.0H, S7, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S734" promotor_-35 complement(1821379..1821385) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1821557..1823332) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /EC_number="3.6.1.12" /experiment="publication(s) with functional evidences, PMID:11886746, 16385024, 22200572, 25246477, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 16385024, 22200572, 25246477, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase" /protein_id="NP_389803.1" /db_xref="EnsemblGenomes-Gn:BSU19220" /db_xref="EnsemblGenomes-Tr:CAB13814" /db_xref="GOA:O34748" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002121" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR006293" /db_xref="InterPro:IPR010997" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018982" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032284" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13522" /db_xref="UniProtKB/Swiss-Prot:O34748" /translation="MLHRAQSLLAHYFGYEKFRSGQDEAIRLVTEARQNTACIMPTGG GKSICYQIPALMFEGTTIVISPLISLMKDQVDALEEAGINAAYINSTQSNQEIYERLN GLKEGAYKLFYITPERLTSIEFIRILQGIDVPLVAIDEAHCISQWGHDFRPSYRNIEI LFRELHDKPVIMALTATATPEVHDDICKQLHIQKENTVYTGFSRENLTFKVVKGENKD RFIDEYVQNNRHEAGIVYTATRKEADRIYERLKRNQVRAGRYHGGLADDVRKEQQERF LNDELQVMVATSAFGMGIDKSNIRFVLHAQIPKDMESYYQEAGRAGRDGLASECVLLF SPQDIMVQRFLIEQSEHEEKQKQDLKKLRQMVDYCHTEDCLQRFILMYFGEKEPDACG QCGNCTDTRAAHDVTREAQMVLSCIIRMKERFGKTMVAQVLAGSKNKKVLENGFSDLS TYGILKHQSVGEISDFIEFLISDDFIRMSDGTFPTLFVSSKGRNVLKGELSVARKEAL KAAAITENDELFERLRMVRKEIAAEQGVPPFVVFSDQTLKEMSGKQPVNDDELLSIKG VGEQKRAKYGRLFLQEIQAYARMTD*" /label="recQ CDS" gene complement(1821557..1823332) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /label="recQ gene" S_feature complement(1823333..1823463) /Source="Nicolas_S_feature" /locus_tag="new_2095786_2095916_c" /HighExp="LoTm, G180, Cold, G135, G150, T5.0H, T4.0H, T3.30H, S2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S735" misc_RNA complement(1823456..1823658) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /product="6Sa RNA" /experiment="publication(s) with functional evidences, PMID:11886746, 15793584, 15811922, 22333917, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 15793584, 15811922, 22333917, 25576829, 26873600; Product type n : RNA" /label="ssrSA RNA" gene complement(1823456..1823658) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /label="ssrSA gene" downshifts complement(1823508) /Source="Nicolas_upshifts" /id="D1059" /incds=0 /nref=34 /ntot=297 /MaxReadThrough="4.06142" /MaxDrop="7.97725" /score="26.8190437" /energy="-12.7" /TU="U1566" /idTUdmin="U1568" /TUdmin=163 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1823656..1823675) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-10" upshifts complement(1823674) /Source="Nicolas_upshifts" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="upshifts" S_feature complement(1823676..1823868) /Source="Nicolas_S_feature" /locus_tag="new_2096129_2096321_c" /HighExp="dia5, Etha, dia15, Diami, S8, S7, C30, G180, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S736" promotor_-35 complement(1823688..1823695) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-35" CDS complement(1823897..1824523) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /EC_number="1.7.-.-" /experiment="publication(s) with functional evidences, PMID:11886746, 18208493, 22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 18208493, 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-dependent NADH-azoreductase" /protein_id="NP_389804.1" /db_xref="EnsemblGenomes-Gn:BSU19230" /db_xref="EnsemblGenomes-Tr:CAB13815" /db_xref="GOA:O35022" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13523" /db_xref="UniProtKB/Swiss-Prot:O35022" /translation="MSTVLFVKSSDRTAEEGVSTKLYEAFLAAYKENNPNDEVVELDL HKENLPYLGRDMINGTFKAGQGMEMTEDEKKQAAIADKYLNQFVKADKVVFAFPLWNF TVPAVLHTYVDYLSRAGVTFKYTQEGPVGLMGGKKVALLNARGGVYSEGPMAALEMSL NFMKTVLGFWGVQDLHTVVIEGHNAAPDQAQEIVEKGLQEAKDLAAKF*" /label="azoJ CDS" gene complement(1823897..1824523) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /label="azoJ gene" downshifts complement(1823913) /Source="Nicolas_upshifts" /id="D1060" /incds=0 /nref=68 /ntot=205 /MaxReadThrough="5.10353" /MaxDrop="5.66408" /score="1.15982687" /energy="-10.9" /TU="U1567,U1568" /idTUdmin="U1567" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1824557..1824576) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-10" upshifts complement(1824570) /Source="Nicolas_upshifts" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="upshifts" promotor_-35 complement(1824590..1824597) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-35" CDS complement(1824674..1825165) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 15496987, 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_389805.2" /db_xref="EnsemblGenomes-Gn:BSU19240" /db_xref="EnsemblGenomes-Tr:CAB13816" /db_xref="GOA:P80872" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR020458" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG13524" /db_xref="UniProtKB/Swiss-Prot:P80872" /translation="MALTKEQTQHLYHKLLDMQKELSGEKKETESMTEEVGELSNGVD NHMADHGTLVTDRMTDQTVKEIDRELLEEVNRALQKMKDGTYGVCEKTGQEIPYERLE AVPYARMTVEAQADVEDDLETDAPSYEREFHEQVKDLSNKETIDQKSSQTYEILDREQ DSK*" /label="yocK CDS" gene complement(1824674..1825165) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /label="yocK gene" downshifts complement(1824683) /Source="Nicolas_upshifts" /id="D1061" /incds=0 /nref=5 /ntot=49 /MaxReadThrough="7.79466" /MaxDrop="4.30433" /score="1.15982687" /energy="-10.9" /TU="U1568,U1573" /idTUdmin="U1571" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1825177..1825195) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-10" upshifts complement(1825189) /Source="Nicolas_upshifts" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="upshifts" promotor_-35 complement(1825209..1825215) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-35" CDS complement(1825240..1825572) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389806.1" /db_xref="EnsemblGenomes-Gn:BSU19250" /db_xref="EnsemblGenomes-Tr:CAB13817" /db_xref="SubtiList:BG13525" /db_xref="UniProtKB/Swiss-Prot:O34976" /translation="MKKMFRSLIRHCLKPELDKLRECEERLSVIEKQKQSSKQESEET YIHIETLNVEKVDYHLEFGELTIDELSGRLNIGATYYIPPEEKDKKCQRKPEAPSTPA VTIRSKRQ*" /label="yocL CDS" gene complement(1825240..1825572) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /label="yocL gene" S_feature complement(1825573..1825863) /Source="Nicolas_S_feature" /locus_tag="new_2098025_2098315_c" /HighExp="Salt, Cold, S3, S8, S4, S7, T5.0H, T3.30H, S6, T4.0H" /AntisenseName="yoyB" /AntisenseCor="0.489341986454357" /AntisenseRegPval="-16.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S737" promotor_-35 1825588..1825593 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-35" promotor_-10 1825608..1825626 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-10" upshifts 1825610 /Source="Nicolas_upshifts" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="upshifts" CDS 1825650..1825877 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097740.1" /db_xref="EnsemblGenomes-Gn:BSU19259" /db_xref="EnsemblGenomes-Tr:CAX52637" /db_xref="UniProtKB/Swiss-Prot:C0H429" /translation="MLPTNINISHLKTNSIGTGSSLTFGSAELRNRCSAIKRNNGFGE QNADGIVMVIPIESIDDRDVSDALSMKINHQ*" /label="yoyB CDS" gene 1825650..1825877 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /label="yoyB gene" CDS complement(1825864..1826340) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11150673, 23155385; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_389808.1" /db_xref="EnsemblGenomes-Gn:BSU19260" /db_xref="EnsemblGenomes-Tr:CAB13818" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG13526" /db_xref="UniProtKB/Swiss-Prot:O34321" /translation="MDFEKMKQWMEFAQQMYGGDFWKQVFDEDQKTPFMTNGQSPFPF AQQDQRGKGDASFPSMDIVDTVAEVQFLIYLPGYRKQDVHILSYGDYLVVKGQRFSYF NEQDFRQKEGKYGSFEKKIPLSDHLHGKMNAIFKDGILYITIQKDEGQAKTIVIDD*" /label="yocM CDS" gene complement(1825864..1826340) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /label="yocM gene" S_feature 1825878..1826385 /Source="Nicolas_S_feature" /locus_tag="new_2098330_2098837" /HighExp="S6, S5, S8, S7, S4, B36, BT, S3, T5.0H, LoTm" /AntisenseName="yocM" /AntisenseCor="0.54530996552252997" /AntisenseRegPval="-21.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.877" /TUlongSig="NA" /TUlongPSig="NA" /label="S738" S_feature complement(1826341..1826443) /Source="Nicolas_S_feature" /locus_tag="new_2098793_2098895_c" /HighExp="Cold, Salt, S8, T5.0H, S3, T-0.40H, T0.0H, S4, T4.0H, S6" /AntisenseName="yozN" /AntisenseCor="0.471443110130365" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S739" promotor_-35 1826358..1826363 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1826378..1826396 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1826387 /Source="Nicolas_upshifts" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="upshifts" CDS 1826407..1826670 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (mother cell in sporulation)" /protein_id="NP_389809.1" /db_xref="EnsemblGenomes-Gn:BSU19270" /db_xref="EnsemblGenomes-Tr:CAB13819" /db_xref="SubtiList:BG13761" /db_xref="UniProtKB/Swiss-Prot:O31846" /translation="MVQPTPYININIFMLKINSFENASAVNVGQNLLAEWQNSDKKNQ GYGQNFGDASGFMGTRSHVDDRDQIDSPASFESEAVNSSIKRK*" /label="yozN CDS" gene 1826407..1826670 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /label="yozN gene" promotor_-10 complement(1826423..1826442) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1826443) /Source="Nicolas_upshifts" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1826445..1826970) /Source="Nicolas_S_feature" /locus_tag="new_2098897_2099422_c" /HighExp="Salt, Cold, T-0.40H, T0.0H, T0.30H, T-1.10H, T-1.40H, T3.30H, T2.0H, S0" /AntisenseName="yocN" /AntisenseCor="-0.51964820699949898" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S740" promotor_-35 complement(1826456..1826460) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1826675..1826908 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (sporulation-related)" /protein_id="NP_389810.1" /db_xref="EnsemblGenomes-Gn:BSU19280" /db_xref="EnsemblGenomes-Tr:CAB13820" /db_xref="SubtiList:BG13527" /db_xref="UniProtKB/Swiss-Prot:O34855" /translation="MFFSPSVVNVGGFKINTMDRGSSLTLGPYQQVDYFLSAKINQGF GEENGDFTPLVVPISNVLDADLVDSNSAKNSVV*" /label="yocN CDS" gene 1826675..1826908 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /label="yocN gene" downshifts 1826895 /Source="Nicolas_upshifts" /id="D1062" /incds=0 /nref=62 /ntot=90 /MaxReadThrough="2.0117" /MaxDrop="7.59451" /score="5.68120132" /energy="-10.9" /TU="NA" /idTUdmin="U1570" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1826994..1827338) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved hypothetical phage protein" /protein_id="NP_389811.1" /db_xref="EnsemblGenomes-Gn:BSU19290" /db_xref="EnsemblGenomes-Tr:CAB13821" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG13762" /db_xref="UniProtKB/Swiss-Prot:O31847" /translation="MGIFSVSRSTDAKKLEALLVEGERIESIYKLRVDQICFTNKRII FFDNKMFSKKKVRVFLPYKTIESFAIQEAGMFDPDTGLLLMTRSKTFELEFAKDTDLS EVQAVLTKHLCS*" /label="yozO CDS" gene complement(1826994..1827338) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /label="yozO gene" downshifts complement(1827015) /Source="Nicolas_upshifts" /id="D1063" /incds=0 /nref=61 /ntot=217 /MaxReadThrough="4.58642" /MaxDrop="4.1868" /score="12.6520239" /energy="-9.6" /TU="U1572,U1573" /idTUdmin="U1574" /TUdmin=616 /isTUend="FALSE" /label="downshifts" S_feature complement(1827339..1827411) /Source="Nicolas_S_feature" /locus_tag="new_2099791_2099863_c" /HighExp="T0.30H, T0.0H, T1.0H, T-0.40H, T1.30H, T-1.10H, Salt, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S741" promotor_-10 complement(1827407..1827426) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1827411) /Source="Nicolas_upshifts" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1827413..1827516) /Source="Nicolas_S_feature" /locus_tag="new_2099865_2099968_c" /HighExp="T0.30H, T0.0H, T-0.40H, T1.0H, T1.30H, Salt, T-1.10H, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S742" promotor_-35 complement(1827440..1827445) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1827503..1827518) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1827516) /Source="Nicolas_upshifts" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1827531..1827540) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1827659) /Source="Nicolas_upshifts" /id="D1064" /incds=0 /nref=117 /ntot=269 /MaxReadThrough="5.5406" /MaxDrop="6.72115" /score="36.7697843" /energy="-10.7" /TU="U1574" /idTUdmin="U1576" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(1827695..1827898) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389812.1" /db_xref="EnsemblGenomes-Gn:BSU19300" /db_xref="EnsemblGenomes-Tr:CAB13822" /db_xref="SubtiList:BG13750" /db_xref="UniProtKB/Swiss-Prot:O31848" /translation="MIHKNWLEKETIKKVKCVQTNAKKYIVNRVLTPGKEYEVKNETE EFLFVVDNTNKVGGYYKEYFEEM*" /label="yozC CDS" gene complement(1827695..1827898) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /label="yozC gene" promotor_-10 complement(1827919..1827938) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1827937) /Source="Nicolas_upshifts" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1827939..1828005) /Source="Nicolas_S_feature" /locus_tag="new_2100391_2100457_c" /HighExp="S7, S8, S6, S5, C30, S4, T4.0H, B60, BC, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.461" /TUlongSig="NA" /TUlongPSig="NA" /label="S743" promotor_-35 complement(1827954..1827961) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1827971..1827978 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-35" upshifts 1827990 /Source="Nicolas_upshifts" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="upshifts" misc_feature complement(1827992..1828004) /Source="Nicolas_upshift_promotors" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1827992..1828011 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-10" S_feature 1827995..1828127 /Source="Nicolas_S_feature" /locus_tag="new_2100447_2100579" /HighExp="BC, M0t90, M9-stat, S2, T2.30H, Sw, Lbstat, M40t90, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S744" upshifts complement(1828016) /Source="Nicolas_upshifts" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="upshifts" CDS 1828128..1829615 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /EC_number="1.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17555270, 23874669, 25409630, 26337367, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17555270, 23874669, 25409630, 26337367, 27797724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxypropionaldehyde dehydrogenase" /protein_id="NP_389813.1" /db_xref="EnsemblGenomes-Gn:BSU19310" /db_xref="EnsemblGenomes-Tr:CAB13823" /db_xref="GOA:O34660" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12582" /db_xref="UniProtKB/Swiss-Prot:O34660" /translation="MSSLTMQVTKRLETFLQGTKKLYIDGKFVPSASGATFDTPNPAT GETLMTLYEAQAADVDKAVKAARKAFDQGEWRTMSPASRSRLMYKLADLMEEHKTELA QLETLDNGKPINETTNGDIPLAIEHMRYYAGWCTKITGQTIPVSGAYFNYTRHEPVGV VGQIIPWNFPLLMAMWKMGAALATGCTIVLKPAEQTPLSALYLAELIDQAGFPAGVIN IIPGFGEDAGEALTNHEAVDKIAFTGSTEIGKKIMSTAAKSIKRVTLELGGKSPNILL PDANLKKAIPGALNGVMFNQGQVCCAGSRVFIHKDQYDEVVDEMASYAESLRQGAGLH KDTQIGPLVSKEQHERVLSYIQKGKDEGAKAVTGGSCPFEAGYFVAPTVFANVEDEMT IAKEEIFGPVLTAIPYETVDEVIERANHSEYGLAAGLWTENVKQAHYIADRLQAGTVW VNCYNVFDAASPFGGYKQSGLGREMGSYALDNYTEVKSVWVNLED*" /label="dhaS CDS" gene 1828128..1829615 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /label="dhaS gene" promotor_-10 complement(1828571..1828588) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1828577) /Source="Nicolas_upshifts" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1828601..1828609) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1829601 /Source="Nicolas_upshifts" /id="D1065" /incds=0 /nref=163 /ntot=260 /MaxReadThrough="3.66831" /MaxDrop="7.01026" /score="24.6079855" /energy="-7.1" /TU="U1575" /idTUdmin="U1575" /TUdmin="-1144" /isTUend="FALSE" /label="downshifts" promotor_-35 1829663..1829668 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1829684..1829702 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1829689 /Source="Nicolas_upshifts" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="upshifts" CDS 1829716..1831614 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /EC_number="4.2.1.137" /EC_number="5.4.99.17" /function="16.13: Shape" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2253626, 18436644, 18630919, 21627333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2253626, 18436644, 18630919, 21627333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="squalene-hopene cyclase, sporulenol synthase (spore protection)" /protein_id="NP_389814.2" /db_xref="EnsemblGenomes-Gn:BSU19320" /db_xref="EnsemblGenomes-Tr:CAB13824" /db_xref="GOA:Q796C3" /db_xref="InterPro:IPR008930" /db_xref="InterPro:IPR018333" /db_xref="InterPro:IPR032696" /db_xref="InterPro:IPR032697" /db_xref="SubtiList:BG12679" /db_xref="UniProtKB/Swiss-Prot:Q796C3" /translation="MGTLQEKVRRFQKKTITELRDRQNADGSWTFCFEGPIMTNSFFI LLLTSLDEGENEKELISSLAAGIHAKQQPDGTFINYPDETRGNLTATVQGYVGMLASG CFHRTEPHMKKAEQFIISHGGLRHVHFMTKWMLAANGLYPWPALYLPLSLMALPPTLP IHFYQFSSYARIHFAPMAVTLNQRFVLINRNISSLHHLDPHMTKNPFTWLRSDAFEER DLTSILLHWKRVFHAPFAFQQLGLQTAKTYMLDRIEKDGTLYSYASATIYMVYSLLSL GVSRYSPIIRRAITGIKSLVTKCNGIPYLENSTSTVWDTALISYALQKNGVTETDGSV TKAADFLLERQHTKIADWSVKNPNSVPGGWGFSNINTNNPDCDDTTAVLKAIPRNHSP AAWERGVSWLLSMQNNDGGFSAFEKNVNHPLIRLLPLESAEDAAVDPSTADLTGRVLH FLGEKVGFTEKHQHIQRAVKWLFEHQEQNGSWYGRWGVCYIYGTWAALTGMHACGVDR KHPGIQKALRWLKSIQNDDGSWGESCKSAEIKTYVPLHRGTIVQTAWALDALLTYENS EHPSVVKGMQYLTDSSSHSADSLAYPAGIGLPKQFYIRYHSYPYVFSLLAVGKYLDSI EKETANET*" /label="sqhC CDS" gene 1829716..1831614 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /label="sqhC gene" promotor_-10 complement(1830659..1830678) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1830667) /Source="Nicolas_upshifts" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1830692..1830701) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1831604..1832449 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /EC_number="1.15.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 20233928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Fe2+-dependent)" /protein_id="NP_389815.1" /db_xref="EnsemblGenomes-Gn:BSU19330" /db_xref="EnsemblGenomes-Tr:CAB13825" /db_xref="GOA:O35023" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="SubtiList:BG12676" /db_xref="UniProtKB/Swiss-Prot:O35023" /translation="MKRESYQAEMFNWCEALKDQIQKRGQLDQFEDQIDKMIEALEDD QTTEEDWYKQAAALYRDITESDDTSERRAYVPIGKHVLPKLPYKYSALEPYISRDIMI LHHTKHHQSYVDGLNKAESELKKARATKNYDLITHWERELAFHGAGHYLHSIFWFSMH PNGKRRPTGALFQMIDLSFGSYSAFKEHFTQASKKVEGVGWAILVWAPRSGRLEILTA EKHQLFSQWDVIPLLPLDVWEHAYYLQYKNDRASYVDHWWNVVDWREAEKRFEQAKEV VWKLY*" /label="sodF CDS" gene 1831604..1832449 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /label="sodF gene" S_feature 1832450..1833956 /Source="Nicolas_S_feature" /locus_tag="new_2104902_2106408" /HighExp="S5, S6, S4, S8, S3, S7, T5.0H, B36, BT, T4.0H" /AntisenseName="yocR" /AntisenseCor="-0.62866346519731298" /AntisenseRegPval="-30.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S745" CDS complement(1832482..1833819) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_389816.1" /db_xref="EnsemblGenomes-Gn:BSU19340" /db_xref="EnsemblGenomes-Tr:CAB13826" /db_xref="GOA:O34383" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13528" /db_xref="UniProtKB/Swiss-Prot:O34383" /translation="MKEANQWSSKLGFILAAAGSAIGLGAIWKFPYVAGTSGGGAFLL IFILFTVLIGLPLLLGEFIIGRRTQKDAVQSYKTLAPGTKWHWIGYLGMVTCFILLSF YSVVGGWILIYIIKGFTGGLSQTSGFDTIFASTISNPYLAVGGQLLFMVVTILVVAKG VSSGIEKASQVLMPALFLLFIILMVRSVTLDGAMEGIKFFLMPDLTAIDANTILYAMG QSFFLLSVGVSVMVTYSAYLEKQENLVQSAVSVTVMNMLVAVMAGIAIFPAVFSFGLK PDQGPVLLFNVLPTVFNQMPFGIIFLLAFLLLFLFAALTSAFSMLEILVAVLSKGDIN KRKRFAWLGGIAIFIVGVPSALSYGVLSDVTIFHLSIFDAADYLVSNILMPLGALLIS IFVPLKIPKQDLFDELKSGSNLKRKWFAVWLLLIRYLSPVAIIIVFLHVIGIF*" /label="yocR CDS" gene complement(1832482..1833819) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /label="yocR gene" downshifts complement(1832493) /Source="Nicolas_upshifts" /id="D1066" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="0.83968" /MaxDrop="2.44824" /score="27.8372036" /energy="-11.1" /TU="NA" /idTUdmin="U1580" /TUdmin=154 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1833847..1833866) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1833862) /Source="Nicolas_upshifts" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1833864..1835022) /Source="Nicolas_S_feature" /locus_tag="new_2106316_2107474_c" /HighExp="M9-stat, T1.30H, B60, T1.0H, T2.0H, T0.30H, T2.30H, T3.0H, T3.30H, Etha" /AntisenseName="yocS" /AntisenseCor="-6.3575129468026695E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S746" promotor_-35 complement(1833881..1833888) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1833940..1833943 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1833958..1833977 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1833958 /Source="Nicolas_upshifts" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="upshifts" CDS 1834038..1835003 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent symporter" /protein_id="NP_389817.1" /db_xref="EnsemblGenomes-Gn:BSU19350" /db_xref="EnsemblGenomes-Tr:CAB13827" /db_xref="GOA:O34524" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG13529" /db_xref="UniProtKB/Swiss-Prot:O34524" /translation="MDIIRKISHFAGQTFGIWVIVFAVLGFSFPSLFTWISSYITIFL GIIMFGMGLTLQADDFKELVRKPWQVIIGVIAQYTIMPLVAFGLAFGLHLPAEIAVGV ILVGCCPGGTASNVMTFLAKGNTALSVAVTTISTLLAPVVTPLLIMLFAKEWLPVSPG SLFISILQAVLFPIIAGLIVKMFFRKQVAKAVHALPLVSVIGIVAIVSAVVSGNRENL LQSGLLIFSVVILHNGIGYLLGFLCAKLLKMDYPSQKAIAIEVGMQNSGLGAALATAH FSPLSAVPSAIFSVWHNLSGSMLATYWSKKVKKKQAGSKSSNLSL*" /label="yocS CDS" gene 1834038..1835003 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /label="yocS gene" downshifts 1834991 /Source="Nicolas_upshifts" /id="D1067" /incds=0 /nref=42 /ntot=166 /MaxReadThrough="3.53218" /MaxDrop="5.09676" /score="30.279305" /energy="-16.4" /TU="U1581" /idTUdmin="U1581" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1835053..1836306) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /EC_number="2.3.1.61" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417, 22720735, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417, 22720735, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase complex (dihydrolipoamide transsuccinylase, E2 subunit)" /protein_id="NP_389818.2" /db_xref="EnsemblGenomes-Gn:BSU19360" /db_xref="EnsemblGenomes-Tr:CAB13828" /db_xref="GOA:P16263" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR006255" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10273" /db_xref="UniProtKB/Swiss-Prot:P16263" /translation="MAEIKVPELAESISEGTIAQWLKQPGDYVEQGEYLLELETDKVN VELTAEESGVLQEVLKDSGDTVQVGEIIGTISEGAGESSAPAPTEKTESKESVKEEKQ AEPAAQEVSEEAQSEAKSRTIASPSARKLAREKGIDLSQVPTGDPLGRVRKQDVEAYE KPASKPAPQQKQQPQAQKAQQSFDKPVEVQKMSRRRQTIAKRLVEVQQTSAMLTTFNE VDMTAVMNLRKRRKDQFFEQNEVKLGFMSFFTKAVVAALKKYPLLNAEIQGDELIVKK FYDIGIAVAADEGLVVPVVRDADRLTFAGIEKEIGELAKKARNNKLTLSELQGGSFTI TNGGTFGSLMSTPILNSPQVGILGMHKIQLRPVAIDEERFENRPMMYIALSYDHRIVD GKEAVGFLVTIKNLLEDPEQLLLEG*" /label="odhB CDS" gene complement(1835053..1836306) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /label="odhB gene" downshifts complement(1835067) /Source="Nicolas_upshifts" /id="D1068" /incds=0 /nref=200 /ntot=253 /MaxReadThrough="5.25481" /MaxDrop="7.42366" /score="11.7726103" /energy="-16.4" /TU="U1582" /idTUdmin="U1582" /TUdmin="-1694" /isTUend="FALSE" /label="downshifts" CDS complement(1836322..1839156) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /EC_number="1.2.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase (E1 subunit)" /protein_id="NP_389819.3" /db_xref="EnsemblGenomes-Gn:BSU19370" /db_xref="EnsemblGenomes-Tr:CAB13829" /db_xref="GOA:P23129" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR011603" /db_xref="InterPro:IPR023784" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR031717" /db_xref="InterPro:IPR032106" /db_xref="SubtiList:BG10272" /db_xref="UniProtKB/Swiss-Prot:P23129" /translation="MFQNSMKQRMNWEDFYGPNLGYALELYDQYTQDPNSIDPDLKEM FDELGAPPSDIKEASGTKEKGRVTADLIQKIASAVRLAEDIRTYGHLNASVNPLRKDE KKSELFPLSDYGLTEEEIKAIPASVICKDAPKNISNGLEAIQYLRNTYKRTISFEFDH VHDFKEREWLTRKIESGELFQKNSAEKLSAVLERLTEVEGFEQFLHRTFVGQKRFSIE GLDALVPVLDDIIAQSVKSGTTSVNIGMAHRGRLNVLAHVLGKPYEIIFSEFQHAPNK DLVPSEGSIGISYGWTGDVKYHLGANRELQDAETKSARITLANNPSHLEFINPIVEGS TRAAQETRTQSGYPVQDETKSLAILIHGDAAFPGEGIVAETLNLSSLKGYQVGGAIHI IANNMIGFTTESAESRSTKYASDLAKGYEIPIVHVNADDPEACLSAVKFAVEYRKTFN KDFLIDLIGYRRYGHNEMDEPSTTQPMLYDAVRKHPTVKQIFAEKLVKEGVVTEEVVQ NIEKSVTKRIEDAYQKVPSKKEHTACEIELPEPVSNGFPDVDTSIDFDVLRKLNGELI NWPESFNVFGKLKRILERRAKAFDDDRKVEWSLAESLAFASILKDGTPIRLTGQDSER GTFAQRNLVLHDSETGKEFVPLHHLSDCSTSFAVHNSPLSEGSVLGFEYGYNVHSPET LVLWEAQYGDFANAAQVYFDQFISAGRAKWGQKSGLVMLLPHGYEGQGPEHSSGRIER FLQLAAENNWTVANLTSAAQYFHILRRQAKMLLREEIRPLVIMTPKSLLRNPNTVSEV QELSESRFQPVYEQSGLSHDYEKVTRLVLSSGKVSIDISDHFNKLEDGKEWLHIARIE QLYPFPAKGVKELFAKLPNLKEIVWVQEEPQNMGAWGYISPYLTEIAPEGVSVQYIGR RRRSSPAEGDPTVHKKEQERIVSDSLTRKN*" /label="odhA CDS" gene complement(1836322..1839156) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /label="odhA gene" promotor_-10 complement(1839251..1839270) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1839266) /Source="Nicolas_upshifts" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1839268..1839384) /Source="Nicolas_S_feature" /locus_tag="new_2111720_2111836_c" /HighExp="dia15, G150, G135, H2O2, Lbexp, dia0, Oxctl, LBGtran, G180, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S747" promotor_-35 complement(1839285..1839292) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1839385..1841301) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23087684; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative activator of nitric oxide reductase" /protein_id="NP_389820.2" /db_xref="EnsemblGenomes-Gn:BSU19380" /db_xref="EnsemblGenomes-Tr:CAB13830" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG13567" /db_xref="UniProtKB/Swiss-Prot:O31849" /translation="MKFIKFNDSTIDSFLFMMLTDLAKTLTKSEAVEVEYGVQSYYNP FEKKIYMSHFWKDRAAEDMEAGLKSDVYLRSVGTRYSSLHEFANFLNDIHRHLTFKSF AKQLFMLLEDIRIEECIKRERPGTKHVFAKRKDMYRKHFSTQLTLNLERSIFTDALFC AIYFKLTAESPLETLPSMREDIDLMRPFIEQQLLRVYEADSTRQVLKIVEDLMDGLEE VLDKDMLNTYFFLPELDYAKAAEQPLFEEEKKAPKLSDDITLPKQSDGDEDIHEEEMP TWHRETEAPSKSFLQFDIEHGAKSDLGKDASREGDDGDQALGSVQGSARQTKRKDYSK LEALESQKDQPNGAGMADGKENKYAFPIYKEPQPATSEEELSYKQQAKTIESYQKRLK QMIQKTLEHKKTLPRTDLHAGRLNNKLLRYFTERNPRLFYKKQEPSSEIDAVFTLLVD CSASMFDKMDETKRGIVLFHEALKSVAVPHQIVGFWEDTNDATEKSQPNYFNTVIPFQ SSLRQDSGPAIMQLEPEEDNRDGYAIRQMTKKMLHRSEAQKFLIVFSDGEPAAFGYEQ NGIVDTSEAVIEARKRGIEVINVFLSNSEIEESQMKTIQDMYGKFSIFVPDVDQLPDV LYPLLKKLLHKSIG*" /label="yojO CDS" gene complement(1839385..1841301) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /label="yojO gene" CDS complement(1841312..1842226) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15491156, 23087684; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nitric-oxide reductase associated protein" /protein_id="NP_389821.1" /db_xref="EnsemblGenomes-Gn:BSU19390" /db_xref="EnsemblGenomes-Tr:CAB13831" /db_xref="GOA:O31850" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011704" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13566" /db_xref="UniProtKB/Swiss-Prot:O31850" /translation="MNRKGNLSMTTQLQHLTLPEDIQQKLLSYKEQPISPEFQSLIGT SGYEAEDEAILFDAIIALAMGKNVLLKGPTGSGKTKLAETLSSYFHKPMHSVNCSVDL DAEALVGYKTIENQSGQATIEFVSGPVTKAMKEGHFLYIDEINMAKPETLPILNGVLD YRKMMTNPFTGEVIRAKSGFGVIAAINEGYVGTVPLNEALKNRFVIIDVPYIKGELLK QVLMSQSALKDEKLIDRFITLSSDLIVQANNGQVSEEAASIRALIDTCDLAAYIPPRR AIERGIVEKLDDDREKAAVRNIAETLFE*" /label="yojN CDS" gene complement(1841312..1842226) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /label="yojN gene" promotor_-10 complement(1842230..1842249) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-10" upshifts complement(1842245) /Source="Nicolas_upshifts" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="upshifts" promotor_-35 complement(1842266..1842270) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-35" CDS complement(1842290..1842880) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /EC_number="1.15.1.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15897454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15897454; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="superoxide dismutase (exported lipoprotein)" /protein_id="NP_389822.1" /db_xref="EnsemblGenomes-Gn:BSU19400" /db_xref="EnsemblGenomes-Tr:CAB13832" /db_xref="GOA:O31851" /db_xref="InterPro:IPR001424" /db_xref="InterPro:IPR024134" /db_xref="InterPro:IPR036423" /db_xref="PDB:1S4I" /db_xref="PDB:1U3N" /db_xref="PDB:1XTL" /db_xref="PDB:1XTM" /db_xref="SubtiList:BG13565" /db_xref="UniProtKB/Swiss-Prot:O31851" /translation="MHRLLLLMMLTALGVAGCGQKKPPDPPNRVPEKKVVETSAFGHH VQLVNREGKAVGFIEIKESDDEGLDIHISANSLRPGASLGFHIYEKGSCVRPDFESAG GPFNPLNKEHGFNNPMGHHAGDLPNLEVGADGKVDVIMNAPDTSLKKGSKLNILDEDG SAFIIHEQADDYLTNPSGNSGARIVCGALLGNNEKQ*" /label="sodC CDS" gene complement(1842290..1842880) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /label="sodC gene" CDS complement(1842973..1844217) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /EC_number="3.5.1.-" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 22139507" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 22139507; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan hydrolase (cell wall-binding d,l-endopeptidase)" /protein_id="NP_389823.1" /db_xref="EnsemblGenomes-Gn:BSU19410" /db_xref="EnsemblGenomes-Tr:CAB13833" /db_xref="GOA:O31852" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13564" /db_xref="UniProtKB/Swiss-Prot:O31852" /translation="MKKKIVAGLAVSAVVGSSMAAAPAEAKTIKVKSGDSLWKLSRQY DTTISALKSENKLKSTVLYVGQSLKVPESSKKSTTSPSNSSKTSTYTVAYGDSLWMIA KNHKMSVSELKSLNSLSSDLIRPGQKLKIKGTSSSSGSNGSKKNSGSNSSGSSKSTYT VKLGDSLWKIANSLNMTVAELKTLNGLTSDTLYPKQVLKIKGSSSPKNGNSGSKKPSN SNPSKTTTYKVKAGDSLWKIANRLGVTVQSIRDKNNLSSDVLQIGQVLTISGASKSNP SNPTKPTKPKDNSGSNIQIGSKIDRMITEAKKYVGVPYRWGGNTPAGFDCSGFIYYLI NNVSSISRLSTAGYWNVMQKVSQPSVGDFVFFTTYKSGPSHMGIYLGGGDFIHASSSG VDISNLSNSYWKQRYLGARSYF*" /label="cwlS CDS" gene complement(1842973..1844217) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /label="cwlS gene" downshifts complement(1842975) /Source="Nicolas_upshifts" /id="D1069" /incds=0 /nref=20 /ntot=183 /MaxReadThrough="4.09529" /MaxDrop="3.77828" /score="11.0350171" /energy="-4.7" /TU="U1584,U1585" /idTUdmin="U1585" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1844280..1844298) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1844293) /Source="Nicolas_upshifts" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1844295..1844515) /Source="Nicolas_S_feature" /locus_tag="new_2116747_2116967_c" /HighExp="S2, Lbstat, T2.30H, M0t90, HiOs, T3.0H, Etha, M40t90, T3.30H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S748" promotor_-35 complement(1844311..1844318) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1844501..1844519) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1844515) /Source="Nicolas_upshifts" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1844531..1844539) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1844599..1845816) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /EC_number="2.4.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative YDP-glycosyltransferase" /protein_id="NP_389824.2" /db_xref="EnsemblGenomes-Gn:BSU19420" /db_xref="EnsemblGenomes-Tr:CAB13834" /db_xref="GOA:O31853" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="SubtiList:BG13563" /db_xref="UniProtKB/Swiss-Prot:O31853" /translation="MANVLMIGFPGEGHINPSIGVMKELKSRGENITYYAVKEYKEKI TALDIEFREYHDFRGDYFGKNATGDEERDFTEMLCAFLKACKDIATHIYEEVKHESYD YVIYDHHLLAGKVIANMLKLPRFSLCTTFAMNEEFAKEMMGAYMKGSLEDSPHYESYQ QLAETLNADFQAEIKKPFDVFLADGDLTIVFTSRGFQPLAEQFGERYVFVGPSITERA GNNDFPFDQIDNENVLFISMGTIFNNQKQFFNQCLEVCKDFDGKVVLSIGKHIKTSEL NDIPENFIVRPYVPQLEILKRASLFVTHGGMNSTSEGLYFETPLVVIPMGGDQFVVAD QVEKVGAGKVIKKEELSESLLKETIQEVMNNRSYAEKAKEIGQSLKAAGGSKKAADSI LEAVKQKTQSANA*" /label="yojK CDS" gene complement(1844599..1845816) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /label="yojK gene" downshifts complement(1844625) /Source="Nicolas_upshifts" /id="D1070" /incds=0 /nref=14 /ntot=145 /MaxReadThrough="1.49168" /MaxDrop="4.07727" /score="9.41396656" /energy="-14.4" /TU="NA" /idTUdmin="U1586" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1845849..1845868) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1845857) /Source="Nicolas_upshifts" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1845882..1845889) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1846052..1846675) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /EC_number="2.7.7.85" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:21566650, 23192352, 24939848, 27252699, 27790204, 28751888" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21566650, 23192352, 24939848, 27252699, 27790204, 28751888; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore diadenylate cyclase" /protein_id="NP_389825.3" /db_xref="EnsemblGenomes-Gn:BSU19430" /db_xref="EnsemblGenomes-Tr:CAB13835" /db_xref="GOA:O31854" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR019457" /db_xref="InterPro:IPR034693" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG13562" /db_xref="UniProtKB/Swiss-Prot:O31854" /translation="MKAMRYEQISENAFKGKIQVYLEQILGDASLILKTLHEKDQCLL CELDDLGHVFQDMQGIASSFYLQSYIEEFTPAFIELAKAIKALSEHKHGALIVIERAD PVERFIQKGTSLHAEISSSLIESIFFPGNPLHDGALLVRENKLVSAANVLPLTTKEVD IHLGTRHRAALGMSGYTDALVLVVSEETGKMSFAKDGVLYPLISPRT*" /label="cdaS CDS" gene complement(1846052..1846675) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /label="cdaS gene" S_feature complement(1846676..1846826) /Source="Nicolas_S_feature" /locus_tag="new_2119128_2119278_c" /HighExp="S8, S5, S7, S6, Etha, S4, M9-stat, S3, C30, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S749" promotor_-35 1846702..1846708 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1846714 /Source="Nicolas_upshifts" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1846722..1846733 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1846740..1846748 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1846756..1846856 /Source="Nicolas_upshift_promotors" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 1846760..1846778 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1846771 /Source="Nicolas_upshifts" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1846809..1846827) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1846816..1846901 /Source="Nicolas_S_feature" /locus_tag="new_2119268_2119353" /HighExp="S8, S7, S4, S5, S6, BT, S3, T5.0H, S2, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigGF" /TUshortPSig="0.00699, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S750" upshifts 1846816 /Source="Nicolas_upshifts" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1846826) /Source="Nicolas_upshifts" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1846843..1846849) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1846877..1846884 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1846897..1846916 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1846903 /Source="Nicolas_upshifts" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="upshifts" CDS 1846941..1848299 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14766544, 15849754, 15855508, 16850406, 16954325, 17114254; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+-driven efflux MatE family protein" /protein_id="NP_389826.1" /db_xref="EnsemblGenomes-Gn:BSU19440" /db_xref="EnsemblGenomes-Tr:CAB13836" /db_xref="GOA:O31855" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13561" /db_xref="UniProtKB/Swiss-Prot:O31855" /translation="MKETQNAREKIKQLLHILIPIFITQAGLSLITFLDTVMSGKVSP ADLAGVAIGSSLWTPVYTGLAGILMAVTPIVAQLLGAEKKQKIPFTVLQAVYVAALLS IAVLVIGYAAVDLILGRLNLDIHVHQIAKHFLGFLSLGIFPLFVYTVLRSFIDSLGKT RVTMMITLSSLPINFVLNYVFIFGKFGMPALGGVGAGLASALTYWCICIISFFIIHKN APFSEYGIFLTMYKFSWKACKNLLKIGLPIGFAVFFETSIFAAVTLLMSHFHTVTIAS HQAAMNFASLLYMLPLSVSMALTIVVGFEAGAARFKDARSYSLIGIMMAIGFSLFTAA CILLFREQIAGMYTSDPDVLRLTQHFLIYALFFQLSDAVAAPIQGALRGYKDVNYTLA AAFVSYWVIGLPVGYMVGTFTSLGAFGYWIGLIAGLAAGAVGLFFRLAKLQKRYSQKQ HI*" /label="mdtK CDS" gene 1846941..1848299 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /label="mdtK gene" promotor_-10 complement(1847283..1847294) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1847288) /Source="Nicolas_upshifts" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1847308..1847314) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1848315..1849163 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665, 20935101, 22287516, 24599254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665, 20935101, 22287516, 24599254; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-antagonist of RsbT; component of the anxiosome (stressosome)" /protein_id="NP_389827.1" /db_xref="EnsemblGenomes-Gn:BSU19450" /db_xref="EnsemblGenomes-Tr:CAB13837" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG13560" /db_xref="UniProtKB/Swiss-Prot:O31856" /translation="MAKNKKLFEYLSQHAETISSTWYETIEETDPNSIYASTDPVVIH NLKSQNLAFNYKINRIFIDDEDVYLPILKEWAFEVTQDQEHLKTPIHYIIREFVRVRD LYVSYVKEFVHLNQNTVKSEEAEDLYHALIKAFDLVIHIFIEEMYKNTSLQLQAQKDM ITELSAPVIVLFHSVGLLPLIGDIDTVRAKLIMENTLHQCAKKKVTQLYIDLSGVAVI DTMVAHQLFSLIEALRLIGVSSTLSGIRPEIAQTAVQLGLSFEGISLRSTLASAIASD LKLKKV*" /label="rsbRC CDS" gene 1848315..1849163 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /label="rsbRC gene" promotor_-10 complement(1848579..1848598) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1848586) /Source="Nicolas_upshifts" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1848612..1848620) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1849126 /Source="Nicolas_upshifts" /id="D1071" /incds=0 /nref=10 /ntot=138 /MaxReadThrough="1.62054" /MaxDrop="3.13267" /score="12.3887642" /energy="-14" /TU="NA" /idTUdmin="U1591" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1849158) /Source="Nicolas_upshifts" /id="D1072" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="1.55562" /MaxDrop="4.60101" /score="23.8391861" /energy="-13.7" /TU="NA" /idTUdmin="U1594" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1849189..1849854) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /EC_number="3.5.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15136574, 20308541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15136574, 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate N-acetylglucosamine deacetylase (second enzyme)" /protein_id="YP_054582.2" /db_xref="EnsemblGenomes-Gn:BSU19460" /db_xref="EnsemblGenomes-Tr:CAB13838" /db_xref="GOA:O31857" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023841" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG13559" /db_xref="UniProtKB/Swiss-Prot:O31857" /translation="MKEHVLVILPHPDDESYGVAGLIALNRKKDIPVTYACATLGEMG RNMGDPFFANRETLPLLRKQELINACKEMDINDLRMLGLRDKTLEFEDDEYLADIMEE IIDDVKPSLIVTFYPGHGVHPDHDACGEAVIRALYRKKKEDRPRTICMAITRNREEVL GEADVVLDIKEVADIKMNALRAHRTQTEGMLRELEEKLKNNEPVMATWFEEEIYWTYQ WND*" /label="bshBB CDS" gene complement(1849189..1849854) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /label="bshBB gene" downshifts complement(1849203) /Source="Nicolas_upshifts" /id="D1073" /incds=0 /nref=189 /ntot=251 /MaxReadThrough="3.68743" /MaxDrop="7.13247" /score="23.8391861" /energy="-13.7" /TU="U1594" /idTUdmin="U1596" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1849873..1850223) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (bacillithiol synthesis operon)" /protein_id="NP_389829.1" /db_xref="EnsemblGenomes-Gn:BSU19470" /db_xref="EnsemblGenomes-Tr:CAB13839" /db_xref="InterPro:IPR014934" /db_xref="InterPro:IPR036492" /db_xref="PDB:1NJH" /db_xref="SubtiList:BG13558" /db_xref="UniProtKB/Swiss-Prot:O31858" /translation="MKAIIKEDVQASLERYADRPVYIHLETTTGSYSAHLNEKNMTVV AYIRNAKVTYHQAKIKGNGPYRVGLKTEEGWIYAEGLTEYTVDEENRLLMAGHLPGGK LAISLQISEKPFTV*" /label="yojF CDS" gene complement(1849873..1850223) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /label="yojF gene" CDS complement(1850220..1850498) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097741.1" /db_xref="EnsemblGenomes-Gn:BSU19479" /db_xref="EnsemblGenomes-Tr:CAX52638" /db_xref="UniProtKB/Swiss-Prot:O68260" /translation="MDNDKEIVKAYASLWNNRSLAHDDAEAVAEAIDLELLDKRTHPR LRKPMLEKYFAAIQRIVNSQLEPAVKYQLVKLHTERAEYLKEERGEQS*" /label="yoyC CDS" gene complement(1850220..1850498) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /label="yoyC gene" promotor_-10 complement(1850525..1850544) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1850541) /Source="Nicolas_upshifts" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1850559..1850565) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1850574..1851470) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636, 23944997; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative N-acetylated toxic metabolites" /protein_id="NP_389830.2" /db_xref="EnsemblGenomes-Gn:BSU19480" /db_xref="EnsemblGenomes-Tr:CAB13840" /db_xref="GOA:O31859" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004626" /db_xref="SubtiList:BG13557" /db_xref="UniProtKB/Swiss-Prot:O31859" /translation="MQHAETKKGVIYTAVSFIMWGLFPLYWKLLEQLPALDILAHRII WSFVFMCIVLFFLRQWKIGWQELRSLKKNGGILSLFLASILISINWFVYIWAVNHGFL LEASLGYYINPLVSVLLGILFLKEKLNRLQLVAVSIAAAGVIISAFQYGSIPYVALLL AFSFGLYGLSKKRTSLPSAIGLTLETFMIMPIALGYLLFSGHVQPAGAESGGTWLLLF LAGVFTALPLLLFAEGAKRLPLYQVGILQYIAPTITLLIGLFVYHEPFSSSKAFTFSC IWAALLLFTFSQVKWKRASKSH*" /label="yojE CDS" gene complement(1850574..1851470) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /label="yojE gene" promotor_-35 1851312..1851321 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1851332 /Source="Nicolas_upshifts" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1851335..1851354 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1851350..1851568 /Source="Nicolas_S_feature" /locus_tag="new_2123802_2124020" /HighExp="S6, S8, S7, BT, S5, B36, G/S, Pyr, B60, SMMPr" /AntisenseName="yojE" /AntisenseCor="-0.562105310907978" /AntisenseRegPval="-23.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S751" promotor_-10 complement(1851494..1851513) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1851514) /Source="Nicolas_upshifts" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1851525..1851532) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1851569..1852042 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17720779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17720779; Product type s: structure" /codon_start=1 /transl_table=11 /product="component of the spore coat" /protein_id="YP_054583.1" /db_xref="EnsemblGenomes-Gn:BSU19490" /db_xref="EnsemblGenomes-Tr:CAE01457" /db_xref="GOA:Q7WY67" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG14190" /db_xref="UniProtKB/Swiss-Prot:Q7WY67" /translation="MFEWNKYFPFHNQFSKEALKKADPKEVETYVNRVMESVFGSDYA AQFPFRDPLPQKEHPAKPDAKPDVKPDIDIFETADHVFVKVPISEEWLEQVRIKHTSH ELWLENLPRADHPKKVNLPCLVKRKGTKAVYKDGLLEVMFQKQQDYNMSEVEIIR*" /label="gerT CDS" gene 1851569..1852042 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /label="gerT gene" downshifts 1852039 /Source="Nicolas_upshifts" /id="D1074" /incds=0 /nref=23 /ntot=53 /MaxReadThrough="-0.0703700000000005" /MaxDrop="9.27889" /score="40.8456275" /energy="-16.6" /TU="NA" /idTUdmin="U1595" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1852077..1852313) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389832.1" /db_xref="EnsemblGenomes-Gn:BSU19510" /db_xref="EnsemblGenomes-Tr:CAB13842" /db_xref="GOA:O31861" /db_xref="SubtiList:BG13555" /db_xref="UniProtKB/Swiss-Prot:O31861" /translation="MYPHHSYLRGIPGPAGYPARSPFLFGAPLVGGLLGGFLGSALFN YSRPYAYPPGPYGYGGGPYGFGAGVPYGGYPGFY*" /label="yojB CDS" gene complement(1852077..1852313) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /label="yojB gene" downshifts complement(1852085) /Source="Nicolas_upshifts" /id="D1075" /incds=0 /nref=37 /ntot=68 /MaxReadThrough="2.10188" /MaxDrop="7.8003" /score="35.4403926" /energy="-16.6" /TU="NA" /idTUdmin="U1597" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1852336..1852355) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1852351) /Source="Nicolas_upshifts" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1852369..1852378) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1852398..1853732) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 3020045, 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/anion permease" /protein_id="NP_389833.1" /db_xref="EnsemblGenomes-Gn:BSU19520" /db_xref="EnsemblGenomes-Tr:CAB13843" /db_xref="GOA:O31862" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG13554" /db_xref="UniProtKB/Swiss-Prot:O31862" /translation="MPILIVAVGVLILLFLIIKVKLNTFVSLIVVSFLVAIGLGMDIN KIVLSIETGIGGQLGHLALVFGLGAMLGRLVSDAGGGYRIAITLIDKFGRKRIQAAVV VASFIIGIALFFEVGLVLLIPIVYAIAKELKMPFLYLGIPMAAALNVTHGFLPPHPAP TAISVAYGAHIGQVLLFGIIIAVPTTVIAGPLFNKFAMKRFPGAYQKHGNLSGLGPRK EFQLDETPGFAISAVTSLFPVIFMAMATIFSLLLSEHSKGKDIIEFIGTPGTAMLISL LLALYTMGYARKISMQEIGRSISESISQIAMMLLIIGGGGAFKQVLIDGGVGDYVADF FRQTNMSPLFVAWTIAAVLRLCLGSATVAALTTAGMAAPLMEAGSVNPALMVLATGAG SVIACHVNDAGFWMVKEFFGLSMKETFQTWTLLTTVLSVTGLGCVLLAGLVM*" /label="yojA CDS" gene complement(1852398..1853732) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /label="yojA gene" S_feature complement(1853733..1853868) /Source="Nicolas_S_feature" /locus_tag="new_2126185_2126320_c" /HighExp="M0t90, M40t90, Lbtran, S1, dia5, Mt0, T0.0H, BI, Lbstat, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25781100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S752" promotor_-10 complement(1853865..1853884) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1853875) /Source="Nicolas_upshifts" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1853899..1853906) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1853964..1853971 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1853986..1854005 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1853989 /Source="Nicolas_upshifts" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1853990..1854096 /Source="Nicolas_S_feature" /locus_tag="new_2126442_2126548" /HighExp="M0t90, M40t90, LoTm, Salt, Cold, BI, HPh, LBGstat, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S753" CDS 1854097..1854486 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /EC_number="5.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tautomerase" /protein_id="NP_389834.1" /db_xref="EnsemblGenomes-Gn:BSU19530" /db_xref="EnsemblGenomes-Tr:CAB13844" /db_xref="GOA:O34882" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG13530" /db_xref="UniProtKB/Swiss-Prot:O34882" /translation="MPLLRFDVIEGRDEKSLQLLLDTAHQAMVEAFGVPERDRYQIVH QHPANELIIQDAGLGFQRTKDMVIISMTSKARTESQKEKLYALLAERLEKKCEISPDD LMVSITENGDADWSFGLGEAQFLNGKL*" /label="yodA CDS" gene 1854097..1854486 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /label="yodA gene" downshifts 1854496 /Source="Nicolas_upshifts" /id="D1076" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="1.20831" /MaxDrop="2.65754" /score="14.4455719" /energy="-13.2" /TU="NA" /idTUdmin="U1599" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1854893..1855231) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17158660, 18208493, 20652907, 27531959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17158660, 18208493, 20652907, 27531959; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_389835.1" /db_xref="EnsemblGenomes-Gn:BSU19540" /db_xref="EnsemblGenomes-Tr:CAB13845" /db_xref="GOA:O34844" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:5HS7" /db_xref="PDB:5HS8" /db_xref="PDB:5HS9" /db_xref="SubtiList:BG13531" /db_xref="UniProtKB/Swiss-Prot:O34844" /translation="MGNTMCPKMESAFSLLGKRWNGLIIHVLMDGPKRFKEITETIPM ISQKMLAERLKELEQNEIVERQVLPETPVKVIYTLTEKGTALQAVFQEMQAWADQFCE PGDTVCEEEK*" /label="arxR CDS" gene complement(1854893..1855231) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /label="arxR gene" promotor_-35 1855254..1855261 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1855275..1855294 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1855284 /Source="Nicolas_upshifts" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="upshifts" S_feature 1855288..1855360 /Source="Nicolas_S_feature" /locus_tag="new_2127740_2127812" /HighExp="dia5, Diami, dia15, Salt, Lbtran, Heat, HiOs, S1, aero, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S754" promotor_-10 complement(1855319..1855338) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1855322) /Source="Nicolas_upshifts" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1855350..1855356) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1855361..1855969 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /EC_number="1.6.99.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 21749987, 24525333, 26312069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="water forming NADH oxidase (nitroreductase)" /protein_id="NP_389836.1" /db_xref="EnsemblGenomes-Gn:BSU19550" /db_xref="EnsemblGenomes-Tr:CAB13846" /db_xref="GOA:P81102" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG13532" /db_xref="UniProtKB/Swiss-Prot:P81102" /translation="MTNTLDVLKARASVKEYDTNAPISKEELTELLDLATKAPSAWNL QHWHFTVFHSDESKAELLPVAYNQKQIVESSAVVAILGDLKANENGEEVYAELASQGY ITDEIKQTLLGQINGAYQSEQFARDSAFLNASLAAMQLMIAAKAKGYDTCAIGGFNKE QFQKQFDISERYVPVMLISIGKAVKPAHQSNRLPLSKVSTWL*" /label="noxC CDS" gene 1855361..1855969 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /label="noxC gene" downshifts 1855959 /Source="Nicolas_upshifts" /id="D1077" /incds=0 /nref=98 /ntot=245 /MaxReadThrough="1.58009" /MaxDrop="5.56809" /score="28.8840715" /energy="-14.3" /TU="NA" /idTUdmin="U1600" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1856012..1856614) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389837.1" /db_xref="EnsemblGenomes-Gn:BSU19560" /db_xref="EnsemblGenomes-Tr:CAB13847" /db_xref="GOA:O34842" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13533" /db_xref="UniProtKB/Swiss-Prot:O34842" /translation="MKHIYEKGTSDNVLLLLHGTGGNEHDLLSLGRFIDPDAHLLGVR GSVLENGMPRFFKRLSEGVFDEKDLVVRTRELKDFIDEAAETHQFNRGRVIAVGYSNG ANIAASLLFHYKDVLKGAILHHPMVPIRGIELPDMAGLPVFIGAGKYDPLCTKEESEE LYRYLRDSGASASVYWQDGGHQLTQHEAEQAREWYKEAIV*" /label="yodD CDS" gene complement(1856012..1856614) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /label="yodD gene" CDS complement(1856630..1857541) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 17407181, 19329649, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-dependent lyase/dioxygenase" /protein_id="NP_389838.1" /db_xref="EnsemblGenomes-Gn:BSU19570" /db_xref="EnsemblGenomes-Tr:CAB13848" /db_xref="GOA:O34543" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13534" /db_xref="UniProtKB/Swiss-Prot:O34543" /translation="MKTEGLHHVTAFARDPQENLRFYTEVLGLRLVKKTVNFDDPGTY HFYFGNQNGDPGTIMTFFPFQGSGQGTVGKGQAGRVYFSVPSGSLSFWKERLEKSGLS LEEKTLFGEKGLIFDDTEDLPLAIMEDAKSGKSEWTPDGITTNEAITGMKGVLLYSYD PQATIQLLTESFGYTKVAEEDQIVRLASSAAVGGVIDVHLHPEKRGVGGYGTVHHVAF RTKKKEQAKWLPIIAENHLPSSEILDREYFTSVYFREKGGILFEIATDEPGFMTDETF AELGTSLKLPEWLEKHRQQITDILPEL*" /label="yodE CDS" gene complement(1856630..1857541) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /label="yodE gene" promotor_-10 complement(1857570..1857589) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1857586) /Source="Nicolas_upshifts" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1857605..1857610) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1857662..1857665 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1857680..1857699 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1857682 /Source="Nicolas_upshifts" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="upshifts" CDS 1857725..1857925 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016, 24843172; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="YP_003097742.1" /db_xref="EnsemblGenomes-Gn:BSU19579" /db_xref="EnsemblGenomes-Tr:CAX52639" /db_xref="GOA:C0H431" /db_xref="InterPro:IPR021741" /db_xref="UniProtKB/Swiss-Prot:C0H431" /translation="MVKKALIVILILLPFVQLALLPLVNRIEPIMFGLPFFHFWLLLW IIVTPLCSFGIYQMQKKDGGLE*" /label="yoyD CDS" gene 1857725..1857925 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /label="yoyD gene" CDS 1857925..1859415 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12823818, 15849754, 16850406, 24142252, 27766092; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite permease" /protein_id="NP_389839.1" /db_xref="EnsemblGenomes-Gn:BSU19580" /db_xref="EnsemblGenomes-Tr:CAB13849" /db_xref="GOA:O34745" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13535" /db_xref="UniProtKB/Swiss-Prot:O34745" /translation="MQGNLTALLITAIIVLTVVCIGFLAGRDKSSRTSVEEWSVGGRR FGGLLVWFLVGADLYTAYTFLGLTSTAFTGGSVAFFAIPYSVLAYFIAYFFLPKLWKV AKIHKLTTLADYARERFNSKLLASLVAIVGVLMLIPYICLQLSGIQDTLQVAGTGYIN VKFVVIISFILVALYTFFSGIKGPTYTAIIKDILVWVIMLFMVVSLPLIHFNGWTPMI DTLVKEAPQMLTIPSEGPKGIPWFITASIVSALALFMWAHAATGVFTAKSADAVRKNS MFLPLYNIVLILVIFLGFIAFLVLPEDTNPRLALLHLIQTSYGGVAQGFAYATIALAS LIPCSIMAIGASNLFANNLYRDLIHPNVSQSKLTLVTRSMVFVVIGLALLFGMLFPTA LVTLQLLGVSGMVQIFPAIAVSLFWKNQTKEATVIGLLAGLAVTFIVYITQSAHGIYE GFWGLAANMIAVVILNPLFVKNAGSNPVIEGLFGKKQDANPNQKGA*" /label="yodF CDS" gene 1857925..1859415 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /label="yodF gene" promotor_-10 complement(1858660..1858671) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1858664) /Source="Nicolas_upshifts" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1858685..1858691) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1859403 /Source="Nicolas_upshifts" /id="D1078" /incds=0 /nref=128 /ntot=189 /MaxReadThrough="1.75716" /MaxDrop="6.37839" /score="42.3111155" /energy="-14.6" /TU="NA" /idTUdmin="U1603" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1859450..1860850) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /EC_number="3.4.21.102" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8996100, 10974125, 14526016, 17114254, 19889088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxy-terminal processing protease (Prc homolog, tail specific protease)" /protein_id="NP_389840.1" /db_xref="EnsemblGenomes-Gn:BSU19590" /db_xref="EnsemblGenomes-Tr:CAB13850" /db_xref="GOA:O34666" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11794" /db_xref="UniProtKB/Swiss-Prot:O34666" /translation="MKRQLKLFFIVLITAVVASALTLFITGNSSILGQKSASTGDSKF DKLNKAYEQIKSDYYQKTDDDKLVDGAIKGMIQSLDDPYSTYMDQEQAKSFDETISAS FEGIGAQVEEKDGEILIVSPIKGSPAEKAGIKPRDQIIKVNGKSVKGMNVNEAVALIR GKKGTKVKLELNRAGVGNIDLSIKRDTIPVETVYSEMKDNNIGEIQITSFSETTAKEL TDAIDSLEKKGAKGYILDLRGNPGGLMEQAITMSNLFIDKGKNIMQVEYKNGSKEVMK AEKERKVTKPTVVLVNDGTASAAEIMAAALHESSNVPLIGETTFGKGTVQTAKEYDDG STVKLTVAKWLTADGEWIHKKGIKPQVKAELPDYAKLPYLDADKTYKSGDTGTNVKVA QKMLKALGYKVKVNSMYDQDFVSVVKQFQKKEKLNETGILTGDTTTKLMIELQKKLSD NDTQMEKAIETLKKEM*" /label="ctpA CDS" gene complement(1859450..1860850) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /label="ctpA gene" downshifts complement(1859474) /Source="Nicolas_upshifts" /id="D1079" /incds=0 /nref=188 /ntot=292 /MaxReadThrough="0.590400000000001" /MaxDrop="7.62713" /score="34.5981085" /energy="-14.6" /TU="NA" /idTUdmin="U1606" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-35 1860621..1860630 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1860642..1860657 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1860656 /Source="Nicolas_upshifts" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1860870..1860889) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1860890) /Source="Nicolas_upshifts" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1860903..1860910) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1860949..1860958 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1860964 /Source="Nicolas_upshifts" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1860971..1860990 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1861003..1861704 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19703276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_389841.1" /db_xref="EnsemblGenomes-Gn:BSU19600" /db_xref="EnsemblGenomes-Tr:CAB13851" /db_xref="GOA:O34954" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13536" /db_xref="UniProtKB/Swiss-Prot:O34954" /translation="MSRYLEMLSLFGVAGAHPGGLAFSKAVLQKAAPSPDQPILDAGC GTGQTAAYLGHLLYPVTVVDKDPIMLEKAKKRFANEGLAIPAYQAELEHLPFSSESFS CVLSESVLSFSRLTSSLQEISRVLKPSGMLIGIEAALKKPMPPAEKKQMMDFYGFTCL HEESEWHKLLRSYGFQKTEAMSLLPEDMEFEPTTEMDLSQTIDPIYYDTLQTHYQLMQ LYSEYMGHCIFIAYK*" /label="yodH CDS" gene 1861003..1861704 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /label="yodH gene" promotor_-35 1861729..1861737 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1861751..1861770 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1861756 /Source="Nicolas_upshifts" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="upshifts" CDS 1861792..1862043 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546, 23155385; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389842.1" /db_xref="EnsemblGenomes-Gn:BSU19610" /db_xref="EnsemblGenomes-Tr:CAB13852" /db_xref="GOA:O34654" /db_xref="SubtiList:BG13537" /db_xref="UniProtKB/Swiss-Prot:O34654" /translation="MERYYHLCKNHQGKVVRITERGGRVHVGRITRVTRDRVFIAPVG GGPRGFGYGYWGGYWGYGAAYGISLGLIAGVALAGLFFW*" /label="yodI CDS" gene 1861792..1862043 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /label="yodI gene" downshifts 1862064 /Source="Nicolas_upshifts" /id="D1080" /incds=0 /nref=49 /ntot=83 /MaxReadThrough="0.88268" /MaxDrop="7.18785" /score="13.9812819" /energy="-15.5" /TU="NA" /idTUdmin="U1607" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1862114..1862935) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /EC_number="3.4.16.4" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8631706, 15187182, 24909784" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8631706, 15187182, 24909784; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase lipoprotein (D-ala releasing from tetrapeptide hydrolysis)" /protein_id="NP_389843.1" /db_xref="EnsemblGenomes-Gn:BSU19620" /db_xref="EnsemblGenomes-Tr:CAB13853" /db_xref="GOA:O34866" /db_xref="InterPro:IPR003709" /db_xref="InterPro:IPR009045" /db_xref="PDB:4OX3" /db_xref="SubtiList:BG13538" /db_xref="UniProtKB/Swiss-Prot:O34866" /translation="MKKSGKWFSLAAALSVTAIVGAGCSMSNGDAQKDTKTTAETKQT EQKTADSKKSNTQNSEFSLESQYFNDIKKVDGLETIQNPENILALVNKQYALPGNYEP SDLVIPDVEFSFEEKIQKRYIRKEAADALKTMFDAAKKEGYELAAVSGYRSYDRQKVI FDNEVSLKGERKAKEAVAYPGESEHQTGLAMDISSRSNGFELNEAFGSTADGKWVQDN AYKYGFIIRYPKNKEDITKYEYEPWHLRYVGKKAAKVIQDNDLTLEEYFEKVKKI*" /label="ldcB CDS" gene complement(1862114..1862935) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /label="ldcB gene" downshifts complement(1862140) /Source="Nicolas_upshifts" /id="D1081" /incds=0 /nref=180 /ntot=242 /MaxReadThrough="0.784690000000001" /MaxDrop="5.88637" /score="-9.13236272" /energy="-6.1" /TU="NA" /idTUdmin="U1609" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1862936..1863017) /Source="Nicolas_S_feature" /locus_tag="new_2135388_2135469_c" /HighExp="dia15, LBGexp, G180, LBGtran, dia0, H2O2, Oxctl, Lbexp, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S755" CDS complement(1863018..1863719) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12571059, 16511068, 21279421, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12571059, 16511068, 21279421, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_389844.1" /db_xref="EnsemblGenomes-Gn:BSU19630" /db_xref="EnsemblGenomes-Tr:CAB13854" /db_xref="GOA:O34925" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR004402" /db_xref="InterPro:IPR018016" /db_xref="InterPro:IPR035994" /db_xref="PDB:4D8V" /db_xref="PDB:4D8X" /db_xref="PDB:4D8Y" /db_xref="PDB:4D98" /db_xref="PDB:4D9H" /db_xref="PDB:4DA0" /db_xref="PDB:4DA6" /db_xref="PDB:4DA7" /db_xref="PDB:4DA8" /db_xref="PDB:4DAB" /db_xref="PDB:4DAE" /db_xref="PDB:4DAN" /db_xref="PDB:4DAO" /db_xref="PDB:4DAR" /db_xref="SubtiList:BG12581" /db_xref="UniProtKB/Swiss-Prot:O34925" /translation="MSVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRG MYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRD VILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFY NDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQT TFHDMIEVALHSVSQ*" /label="deoD CDS" gene complement(1863018..1863719) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /label="deoD gene" S_feature complement(1863720..1863809) /Source="Nicolas_S_feature" /locus_tag="new_2136172_2136261_c" /HighExp="dia15, G180, dia5, LBGtran, dia0, LBGexp, Lbexp, G150, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S756" promotor_-10 complement(1863794..1863813) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1863809) /Source="Nicolas_upshifts" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1863829..1863833) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1863867..1863873 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1863888..1863899 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1863905 /Source="Nicolas_upshifts" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="upshifts" CDS 1863921..1864046 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24079885" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097743.1" /db_xref="EnsemblGenomes-Gn:BSU19639" /db_xref="EnsemblGenomes-Tr:CAX52640" /db_xref="UniProtKB/Swiss-Prot:C0H432" /translation="MGKKHRNRITGQKKNNHIPEKDIIAAEEAHGKEYSAAKRKP*" /label="yoyE CDS" gene 1863921..1864046 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /label="yoyE gene" downshifts 1864044 /Source="Nicolas_upshifts" /id="D1082" /incds=0 /nref=9 /ntot=26 /MaxReadThrough="0.67198" /MaxDrop="4.89617" /score="16.4028635" /energy="-8.5" /TU="NA" /idTUdmin="U1610" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1864086..1864400) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24079885, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24079885, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="shape determination factor" /protein_id="NP_389845.2" /db_xref="EnsemblGenomes-Gn:BSU19640" /db_xref="EnsemblGenomes-Tr:CAB13855" /db_xref="InterPro:IPR025923" /db_xref="SubtiList:BG13539" /db_xref="UniProtKB/Swiss-Prot:O30472" /translation="MMLSVFKKKSCSYDVTIFQTPRFGEKKGYRAVYRTELNGSDHQD VLKRAFSLFNVFDTVPSDYDARFMATGDVILIDEGRKGKTYYQLLPAGWRKINRLIVQ TT*" /label="yodL CDS" gene complement(1864086..1864400) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /label="yodL gene" downshifts complement(1864098) /Source="Nicolas_upshifts" /id="D1083" /incds=0 /nref=96 /ntot=232 /MaxReadThrough="1.74792" /MaxDrop="5.79235" /score="-0.334745097" /energy="-8.5" /TU="NA" /idTUdmin="U1611" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1864421..1864439) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1864428) /Source="Nicolas_upshifts" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1864450..1864458) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1864461..1865072) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /EC_number="3.1.3.27" /EC_number="3.1.3.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27528508, 28168443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27528508, 28168443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol phosphate (PGP) phosphatase; undecaprenyl-pyrophosphate phosphatase (promiscuous activity)" /protein_id="NP_389846.1" /db_xref="EnsemblGenomes-Gn:BSU19650" /db_xref="EnsemblGenomes-Tr:CAB13856" /db_xref="GOA:O34349" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR036938" /db_xref="PDB:5JKI" /db_xref="SubtiList:BG13540" /db_xref="UniProtKB/Swiss-Prot:O34349" /translation="MYKPVSLFLFFLILAAAIHTNAVQSADEAISKAAVLIRQPWLNE VMTGITHLGASSFLLPLIVIIGAGMFFYRKTWDGLLMLLVFGTDRLLNKVLKEWIERV RPDFAPLVHESSFSFPSGHSMNAACVYPVIAYFLVKHLPFLSKHKKMVYIIAGVIAVL VGISRVYLGVHFVTDVLGGFSLGLLLFFLVKGFDEKIKRFRQK*" /label="pgpB CDS" gene complement(1864461..1865072) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /label="pgpB gene" CDS complement(1865150..1865326) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389847.1" /db_xref="EnsemblGenomes-Gn:BSU19660" /db_xref="EnsemblGenomes-Tr:CAB13857" /db_xref="InterPro:IPR025545" /db_xref="SubtiList:BG13751" /db_xref="UniProtKB/Swiss-Prot:O31863" /translation="MKEIDLVIDTEEIAEFFYRELARRGYIPSEDELFEIADITFDYL IEKCMIDEELDEDE*" /label="yozD CDS" gene complement(1865150..1865326) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /label="yozD gene" downshifts complement(1865154) /Source="Nicolas_upshifts" /id="D1084" /incds=0 /nref=35 /ntot=48 /MaxReadThrough="3.33111" /MaxDrop="5.99901" /score="19.8458751" /energy="-11.9" /TU="U1612,U1613" /idTUdmin="U1615" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1865165) /Source="Nicolas_upshifts" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1865169..1865188) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1865204..1865207) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1865340..1865358) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-10" upshifts complement(1865361) /Source="Nicolas_upshifts" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="upshifts" S_feature complement(1865363..1865584) /Source="Nicolas_S_feature" /locus_tag="new_2137815_2138036_c" /HighExp="S8, S7, S6, BT, B36, Pyr, G/S, H2O2, S5, G135" /AntisenseName="yoyF" /AntisenseCor="0.43167183745996701" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S757" promotor_-35 complement(1865374..1865379) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-35" promotor_-35 1865384..1865389 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1865404..1865422 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1865406 /Source="Nicolas_upshifts" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="upshifts" CDS 1865445..1865588 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097744.1" /db_xref="EnsemblGenomes-Gn:BSU19669" /db_xref="EnsemblGenomes-Tr:CAX52641" /db_xref="GOA:C0H433" /db_xref="UniProtKB/Swiss-Prot:C0H433" /translation="MIAKMMEALDGERFDIIMEKTLKGMTRVMIWGCLPYFLYVLIRM FTN*" /label="yoyF CDS" gene 1865445..1865588 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /label="yoyF gene" CDS complement(1865585..1866265) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389848.1" /db_xref="EnsemblGenomes-Gn:BSU19670" /db_xref="EnsemblGenomes-Tr:CAB13858" /db_xref="SubtiList:BG13541" /db_xref="UniProtKB/Swiss-Prot:O34414" /translation="MKQNKPKFQVGDIVVVIMYGTVGTITKVHQIDKHYLYEVNHNEV LYFESSIQLYKDYEGVIVDMEKLDIEYEFLIGDVVYVKDYGKELFRIIGHRTEIWRYL EDGWEDIIYELTRLKDGEWLETEEEDLTLVLRKYEMDQFVHQLLFVHYVGETGHEIGE DIASSALLQFEGGDEDQDTLHILAVSIVDELLDIYNDYKILYEMFQDEEYKDMMMFVL ESLKEHFS*" /label="yodN CDS" gene complement(1865585..1866265) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /label="yodN gene" S_feature 1865589..1866600 /Source="Nicolas_S_feature" /locus_tag="new_2138041_2139052" /HighExp="LoTm, S3, S8, S7, S4, T5.0H, BT, T4.0H, Pyr, S6" /AntisenseName="yodN" /AntisenseCor="0.52628108909126403" /AntisenseRegPval="-19.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S758" promotor_-10 complement(1866292..1866311) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1866298) /Source="Nicolas_upshifts" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1866325..1866334) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1866416..1866640) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389849.1" /db_xref="EnsemblGenomes-Gn:BSU19680" /db_xref="EnsemblGenomes-Tr:CAB13859" /db_xref="InterPro:IPR010673" /db_xref="InterPro:IPR023089" /db_xref="InterPro:IPR036806" /db_xref="PDB:2FJ6" /db_xref="SubtiList:BG13752" /db_xref="UniProtKB/Swiss-Prot:O31864" /translation="MKSFYHYLLKYRHPKPKDSISEFANQAYEDHSFPKTSTDYHEIS SYLELNADYLHTMATFDEAWDQYESEVHGR*" /label="yozE CDS" gene complement(1866416..1866640) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /label="yozE gene" downshifts complement(1866430) /Source="Nicolas_upshifts" /id="D1085" /incds=0 /nref=115 /ntot=243 /MaxReadThrough="1.81033" /MaxDrop="7.07662" /score="34.0666929" /energy="-10.8" /TU="NA" /idTUdmin="U1616" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1866681..1866700) /Source="Nicolas_upshift_promotors" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1866693) /Source="Nicolas_upshifts" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1866727..1867005) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344, 24914178" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097745.1" /db_xref="EnsemblGenomes-Gn:BSU19689" /db_xref="EnsemblGenomes-Tr:CAX52642" /db_xref="InterPro:IPR022451" /db_xref="InterPro:IPR022453" /db_xref="UniProtKB/Swiss-Prot:C0H434" /translation="MKTCEWCGELEAVPGRNTVYWELPDGTRAIELTDTPAMVCSSCG MTYQEENTVKEIEDQLLLIQTKKLPESLTYQQLMETERILKRNYFDFS*" /label="yokU CDS" gene complement(1866727..1867005) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /label="yokU gene" CDS complement(1867002..1868417) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /EC_number="5.4.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10629195, 10839984, 11148055, 17254853, 18307109, 21538109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629195, 10839984, 11148055, 17254853, 18307109, 21538109; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="lysine 2,3-aminomutase" /protein_id="NP_389850.1" /db_xref="EnsemblGenomes-Gn:BSU19690" /db_xref="EnsemblGenomes-Tr:CAB13860" /db_xref="GOA:O34676" /db_xref="InterPro:IPR003739" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022459" /db_xref="InterPro:IPR025895" /db_xref="SubtiList:BG13542" /db_xref="UniProtKB/Swiss-Prot:O34676" /translation="MKNKWYKPKRHWKEIELWKDVPEEKWNDWLWQLTHTVRTLDDLK KVINLTEDEEEGVRISTKTIPLNITPYYASLMDPDNPRCPVRMQSVPLSEEMHKTKYD LEDPLHEDEDSPVPGLTHRYPDRVLFLVTNQCSMYCRYCTRRRFSGQIGMGVPKKQLD AAIAYIRETPEIRDCLISGGDGLLINDQILEYILKELRSIPHLEVIRIGTRAPVVFPQ RITDHLCEILKKYHPVWLNTHFNTSIEMTEESVEACEKLVNAGVPVGNQAVVLAGIND SVPIMKKLMHDLVKIRVRPYYIYQCDLSEGIGHFRAPVSKGLEIIEGLRGHTSGYAVP TFVVDAPGGGGKIALQPNYVLSQSPDKVILRNFEGVITSYPEPENYIPNQADAYFESV FPETADKKEPIGLSAIFADKEVSFTPENVDRIKRREAYIANPEHETLKDRREKRDQLK EKKFLAQQKKQKETECGGDSS*" /label="kamA CDS" gene complement(1867002..1868417) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /label="kamA gene" promotor_-35 1867673..1867676 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1867692..1867711 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1867697 /Source="Nicolas_upshifts" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1868446..1869273) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21538109, 24914178" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epsilon-amino-beta-lysine acetyl transferase" /protein_id="NP_389851.1" /db_xref="EnsemblGenomes-Gn:BSU19700" /db_xref="EnsemblGenomes-Tr:CAB13861" /db_xref="GOA:O34895" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022525" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13543" /db_xref="UniProtKB/Swiss-Prot:O34895" /translation="MLKSIKSSGVTAVLDHDGFNKRIRVVRYDGAIEKALPDIVAAAK EENAEKIIVYAKQHDEPILAKQLFAPEGYLKGYYLGHSACVMVRYLSESRRQTDSYTE EQEIIEAIYRTAPRLRNDSTPVFTMRKAETNDMYQLSMLYKKVFRTYPTPVFDPAYIE KTMNANTVYYIMLDHDRLISAASAEINPELGHAEITDCAVLPEYRGHSLTSFLIEALE KEMAGEDIVHVFSLARASSFGMNAVLYHSGYQYGGRLINNCFIAEGLENMNIWCKQL* " /label="kamB CDS" gene complement(1868446..1869273) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /label="kamB gene" CDS complement(1869251..1870561) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /EC_number="3.5.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative deacetylase" /protein_id="NP_389852.1" /db_xref="EnsemblGenomes-Gn:BSU19710" /db_xref="EnsemblGenomes-Tr:CAB13862" /db_xref="GOA:O34984" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR033687" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12569" /db_xref="UniProtKB/Swiss-Prot:O34984" /translation="MRMQDIERKVIEWLDQHSAKAIRLLKRLIGEKSTLGSEFNAQAV VLEKLRQFHMDIDVWEPSIKQLKQHPYFKSNRSDFHESPNIVAKKTGAGGGRSLILNG HIDVVPEGSVKDWKYEPYQAVEENGKIYGRGSTDMKGGNTALLFALEALHACDVKLKG DVLFQSVVDEECGGAGTLSAIMRGYRADGALIPEPTNMKLFIKQQGSMWFRITVKGLS AHGGTRYEGVSAIEKSMHVITAIQELEKVRNARISDPLYDNIPIPVPVNIGTISGGAW PSSVADRVVIEGRCGIAPHEKPEAVKLELENWLKDLEYHDEWFKRHPVQVEWFGAQWL PNDLPDDHPLISVLQSAYQKMKQTEPIIEASPWGTDGGLLYHAGDTPVIVFGPGETKT AHQANEYIEVEAMIESAKIIALFVMDWCGLHTDGEDADAQVNKE*" /label="yodQ CDS" gene complement(1869251..1870561) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /label="yodQ gene" CDS complement(1870570..1871223) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyloate-acetoacetate CoA-transferase" /protein_id="NP_389853.1" /db_xref="EnsemblGenomes-Gn:BSU19720" /db_xref="EnsemblGenomes-Tr:CAB13863" /db_xref="GOA:O34466" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="SubtiList:BG13544" /db_xref="UniProtKB/Swiss-Prot:O34466" /translation="MGLGVAEREQIAKRAATEIKQGMIVNLGIGIPSLVPNFLKPDMQ VMFQAENGVLGIGESPEKGEEDAHLCNAAGYPVRAVKGASYFDTTMSFAMIRKGKIDI TILGALQVSQSGDLANWLVPGKKVPGMGGAMELAQKAKKVVVVMSHTDQKGRPKLTER CTLPLTAAGCVDLIITEKAVLEVDSHHFILKELMNGSTIDEVTRLTEAEIKIDMPFS* " /label="yodR CDS" gene complement(1870570..1871223) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /label="yodR gene" CDS complement(1871208..1871897) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxoacid CoA-transferase" /protein_id="NP_389854.1" /db_xref="EnsemblGenomes-Gn:BSU19730" /db_xref="EnsemblGenomes-Tr:CAB13864" /db_xref="GOA:O34317" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="SubtiList:BG13545" /db_xref="UniProtKB/Swiss-Prot:O34317" /translation="MAPFQKAISIDTAIADVRDGSVLMFGGFGGVGSPPSLIEAILDS GVTDLTVICNDAGFPDIGIGPLIVNQRVKTLIASHIGSNPVAGKQMTEGTLEVQFSPQ GTLAERIRAGGAGLGGILTDVGIDNQMVCEKKDIVTVAGKRYLIEEALTADFAFINAY IADEFGNLTYDKTARNMNPLMAMAARRTFAEAERIVPMGEISEEMIVTPGVFVEGVVR SEGVKWKWAWE*" /label="yodS CDS" gene complement(1871208..1871897) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /label="yodS gene" CDS complement(1871904..1873238) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /EC_number="2.6.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10839984, 15150230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminovalerate aminotransferase" /protein_id="NP_389855.1" /db_xref="EnsemblGenomes-Gn:BSU19740" /db_xref="EnsemblGenomes-Tr:CAB13865" /db_xref="GOA:O34662" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13546" /db_xref="UniProtKB/Swiss-Prot:O34662" /translation="MSSYLIKPELSSAYPVVSYAKGSYVYDQTGKKYLDGSSGAVTCN IGHGVRDVTEKLKEQLDQVSFAYRSQFTSEPAEQLAALLAQELPGDVNWSFFVNSGSE AIETAMKIAIQYWQEKKQTQKSIFLSRWSSYHGITLGALSLSGFYERRYRFTHLIERY PAISAPHIYRLNHETEEDFVQTAADELDTMIKRIGSQFIAGFVAEPIIGAAGAAITPP PGYYERLSEVCRTHDVLFIADEVMTGLGRTGRMLATEHWDTVPDIAVLGKGLGAGYAP IAAAVVSDSIIETIKQGSGVIMSGHTYSAHPYSAKAALEVLRYVLKHGLIKQSEKKGA VLKKKLDEAASQSGIIGEVRGKGLLLGIEFVADQKTKKVFPPEQAITQLIVSEAKKRG LIVYPSKAGIDSGEGDAVIIAPPFTISDGEMEELISIFSETVAAVEKNLKKD*" /label="yodT CDS" gene complement(1871904..1873238) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /label="yodT gene" CDS complement(1873219..1873374) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513966.1" /translation="MLDAEISKEPSLLGRLFLCEKVFAGNVMPPFGHSYNMVKGVLRW EHEQLFD*" /label="conserved hypothetical protein CDS" gene complement(1873219..1873374) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /label="gene" promotor_-10 complement(1873257..1873275) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1873273) /Source="Nicolas_upshifts" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1873291..1873296) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1873368..1873601) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a type I toxin family (sporulation operon)" /protein_id="YP_003097746.2" /db_xref="EnsemblGenomes-Gn:BSU19749" /db_xref="EnsemblGenomes-Tr:CAX52643" /db_xref="GOA:C0H435" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H435" /translation="MSGCILYFIISLHEIGVCTNHLGLGPHKMSYIVIRKDENSMYGY SGYGYGFGCGTNTFVLIVVLFILLIIVGAAFIC*" /label="yoyG CDS" gene complement(1873368..1873601) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /label="yoyG gene" downshifts complement(1873375) /Source="Nicolas_upshifts" /id="D1086" /incds=0 /nref=96 /ntot=237 /MaxReadThrough="2.70127" /MaxDrop="7.98506" /score="25.3834194" /energy="-16.5" /TU="NA" /idTUdmin="U1620" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-35 1873477..1873481 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1873490..1873504 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1873505 /Source="Nicolas_upshifts" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1873506..1873525) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1873515) /Source="Nicolas_upshifts" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1873540..1873549) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1873561..1874340) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 7592393, 10066829, 27260256" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 7592393, 10066829, 27260256; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389856.1" /db_xref="EnsemblGenomes-Gn:BSU19750" /db_xref="EnsemblGenomes-Tr:CAB13866" /db_xref="GOA:P42093" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11197" /db_xref="UniProtKB/Swiss-Prot:P42093" /translation="MTGHYSKTEHQYILLTSESASFDHYSVYRDPQLPQIFSHNFVQL HDTFPLERLLNFLPSVPKLLDANYLHLKASPQHVFPLGLKQSLVKSGFVVEDELLYDM KLSDWKGQMGHPLTAWGTAKSLSDGSSIMKIYDSIYIGEAIAEQKLKRKYPFYEADII ILVVCYSDQAQKVPIGCGELFIDHQEKTAKIEEVAILDQFQRKGYGSILVKEMLSIAK SLGMEAAYLVAASTDGATQFYEKLTFKKYERVHTVFHYFLT*" /label="cgeE CDS" gene complement(1873561..1874340) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /label="cgeE gene" CDS complement(1874369..1875649) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in maturation of the outermost layer of the spore" /protein_id="NP_389857.1" /db_xref="EnsemblGenomes-Gn:BSU19760" /db_xref="EnsemblGenomes-Tr:CAB13867" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11196" /db_xref="UniProtKB/Swiss-Prot:P42092" /translation="MGEKVSIILTSYNKPDYLQKAIESVIQQTHDLWELFIMDDHSNA ETTAVIHKYLHDRRIQYHNSFVHPADRLKTARYATLINSALPFADGDYISYLTDDTVY HPERLSRMVQEFSHKPEAQAVYSKQKVVHVNERGEEISHFYRNANAVLDQAAFQVDHC SVMHRRSLLNLIHHKFGGYWDDDMKHWNHGDAIFWARLNNFTPFLPINEVLDTTYKTP DSFQNAYRFLPADLIDGSFVKGSDQNVYFFDQGVRHPVGEKWGFLYLNRTVAVPDPYL FQYRIGKILNIPNYILVKEADHPAIFYIEAGKKRRIVDQYAFQFYQFQRKDIVTIGKE EMETLPEGPPITWKRSELIKNPPGRRLFFIEREPFLFLNGVFHPISEQVTRKFFLHQK PISASFRNIQQFPIGKPFYPVYDEIIKKLNIATE*" /label="cgeD CDS" gene complement(1874369..1875649) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /label="cgeD gene" promotor_-10 complement(1875017..1875035) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1875033) /Source="Nicolas_upshifts" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1875049..1875056) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1875617..1875635) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1875627) /Source="Nicolas_upshifts" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1875651..1875656) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1875714..1876019) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389858.1" /db_xref="EnsemblGenomes-Gn:BSU19770" /db_xref="EnsemblGenomes-Tr:CAB13868" /db_xref="SubtiList:BG11195" /db_xref="UniProtKB/Swiss-Prot:P42091" /translation="MDLEKQVDREENQDDLHFILLLLILLIRQSSSEGNPSDLRRQLV FAKELGVPVSKVNLINGDTLQNVIVKEVLTDLVIFQNPLNNTRSHVSLSSVVSWGAF* " /label="cgeC CDS" gene complement(1875714..1876019) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /label="cgeC gene" downshifts complement(1875847) /Source="Nicolas_upshifts" /id="D1087" /incds=1 /nref=2 /ntot=28 /MaxReadThrough="5.32389" /MaxDrop="2.61092" /score="23.1569137" /energy="-13.4" /TU="U1623" /idTUdmin="U1623" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1876043..1876062) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-10" upshifts complement(1876058) /Source="Nicolas_upshifts" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="upshifts" promotor_-35 complement(1876076..1876085) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-35" promotor_-35 1876155..1876164 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1876178..1876197 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1876178 /Source="Nicolas_upshifts" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1876199) /Source="Nicolas_upshifts" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1876201..1876215) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1876224..1876228) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1876224..1876625 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:759239, 14702409, 15621419, 19933362, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 759239, 14702409, 15621419, 19933362, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore outermost layer component" /protein_id="NP_389859.1" /db_xref="EnsemblGenomes-Gn:BSU19780" /db_xref="EnsemblGenomes-Tr:CAB13869" /db_xref="SubtiList:BG11193" /db_xref="UniProtKB/Swiss-Prot:P42089" /translation="MSSENAQLKKDLIKAVLSPLFPTATEGGENMDSNLKALLDAAID QKVDESETVTAESILDPSLPARWIFARITPGTTISIVTDSGDMIGPVVFVAFDQVHGI VFVTQESSVTPAGQATTLIDVDKVESVTFFS*" /label="cgeA CDS" gene 1876224..1876625 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /label="cgeA gene" CDS 1876632..1877585 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389860.2" /db_xref="EnsemblGenomes-Gn:BSU19790" /db_xref="EnsemblGenomes-Tr:CAB13870" /db_xref="InterPro:IPR024542" /db_xref="SubtiList:BG11194" /db_xref="UniProtKB/Swiss-Prot:P42090" /translation="MKVLYIQSGYGGIYSYFDRWAEECFQNTHTEYMIADKPEAESLM KIEAFQPDFTLMMVGDRVPHDWLTWLKGKDIPVYVWLTEDPFYMDISLQVIKLADAIL TIEQNAALYYQELGYQNVYYVPIPVNHRLFKKMGTEHSYHSNLLIIGYPYPNRVQLMK EAVHLPFTVRVIGKEWGKYLPKKVLKQPHIDVVSTWVPPEQAVHYYNGADIVINAHRP YHFAFNQNTMRIKNASFNNRTFDIAACEAFQLTDLPAAHPFSSIISYHGMNDFKEKAA FYINHPEERQKAAAANYKETVPAFTFDELPAKLKAIHLALS*" /label="cgeB CDS" gene 1876632..1877585 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /label="cgeB gene" downshifts 1877575 /Source="Nicolas_upshifts" /id="D1088" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="2.94229" /MaxDrop="5.87549" /score="22.1420541" /energy="-9" /TU="NA" /idTUdmin="U1624" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1877656..1878804) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /EC_number="3.1.3.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phytase" /protein_id="NP_389861.1" /db_xref="EnsemblGenomes-Gn:BSU19800" /db_xref="EnsemblGenomes-Tr:CAB13871" /db_xref="GOA:P42094" /db_xref="InterPro:IPR003431" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11198" /db_xref="UniProtKB/Swiss-Prot:P42094" /translation="MKVPKTMLLSTAAGLLLSLTATSVSAHYVNEEHHFKVTAHTETD PVASGDDAADDPAIWVHEKHPEKSKLITTNKKSGLVVYDLDGKQLHSYEFGKLNNVDL RYDFPLNGEKIDIAAASNRSEGKNTIEVYAIDGDKGKLKSITDPNHPISTNISEVYGF SLYHSQKTGAFYALVTGKQGEFEQYEIVDGGKGYVTGKKVREFKLNSQTEGLVADDEY GNLYIAEEDEAIWKFNAEPGGGSKGQVVDRATGDHLTADIEGLTIYYAPNGKGYLMAS SQGNNSYAMYERQGKNRYVANFEITDGEKIDGTSDTDGIDVLGFGLGPKYPYGIFVAQ DGENIDNGQAVNQNFKIVSWEQIAQHLGEMPDLHKQVNPRKLKDRSDG*" /label="phyC CDS" gene complement(1877656..1878804) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /label="phyC gene" downshifts complement(1877673) /Source="Nicolas_upshifts" /id="D1089" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="2.64059" /MaxDrop="5.59857" /score="17.7154517" /energy="-8.7" /TU="NA" /idTUdmin="U1629" /TUdmin=2024 /isTUend="FALSE" /label="downshifts" promotor_-35 1878817..1878821 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1878830..1878849) /Source="Nicolas_upshift_promotors" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1878837..1878856 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1878839) /Source="Nicolas_upshifts" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 1878847 /Source="Nicolas_upshifts" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1879108..1879116 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1879130..1879149 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1879133 /Source="Nicolas_upshifts" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="upshifts" CDS 1879174..1880199 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014664318.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="polysaccharide biosynthesis protein" /protein_id="WP_003230816.1" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /translation="MPKQQTAELKPFFHNKTVLVTGGTGSIGSQIVKRLLMLTPKQVI VFSKDDSKQYVMSQKYAEDKRLLFVLGDVRDHRRVNQVMKGVDIVFHAAALKQVPTCE DHPFEAIQTNLIGGQNVVEAALSHRVQHVINISTDKAVSPVNTMGATKLLSEKLFHQA NRHVQNKGTLFCSVRFGNVLGSRGSVIPILFEQMMEGEPLTITDKNMTRFFMSIDDAA TLTLQSAAITKGGETFIFKMESLKLEELIHGFEEYASQHGLPRPAAVEVGKRPGEKLH EELTSPHEIESLYEWGNLYAILPEPEKHPDFRKVNLPGYQSDQAPLITKERIAQIIEE LHQEKKA*" /label="Delta6_BSU_19810-BSU_21670" gene 1879174..1880199 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /label="Delta6_BSU_19810-BSU_21670" downshifts 1879577 /Source="Nicolas_upshifts" /id="D1090" /incds=0 /nref=18 /ntot=39 /MaxReadThrough="0.75679" /MaxDrop="7.79081" /score="-6.65536786" /energy="-8.7" /TU="NA" /idTUdmin="U1628" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 <1879579..1879583 /Source="Nicolas_upshift_promotors" /id="U1702" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1418 /SigmaFactorBS="tttcatttttgacctcacagccactaATAGTTTCCActaaga aaagtagTAAGTATCTTAAAAAACAGAtaaagctgtatctcctgtgaacacaatgggt g" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" SCAR 1879593..1879594 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta_SP_beta" downshifts 1880191 /Source="Nicolas_upshifts" /id="D1134" /incds=0 /nref=22 /ntot=177 /MaxReadThrough="2.90949" /MaxDrop="5.54327" /score="-2.31796312" /energy="-13.5" /TU="NA" /idTUdmin="U1701" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1880243..1880674) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /EC_number="1.8.4.12" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15680230, 16803968, 17031545, 18239417, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine R-sulfoxide reductase" /protein_id="NP_390051.1" /db_xref="EnsemblGenomes-Gn:BSU21680" /db_xref="EnsemblGenomes-Tr:CAB14086" /db_xref="GOA:P54155" /db_xref="InterPro:IPR002579" /db_xref="InterPro:IPR011057" /db_xref="InterPro:IPR028427" /db_xref="PDB:2KZN" /db_xref="PDB:3E0O" /db_xref="SubtiList:BG11628" /db_xref="UniProtKB/Swiss-Prot:P54155" /translation="MAYNKEEKIKSLNRMQYEVTQNNGTEPPFQNEYWDHKEEGLYVD IVSGKPLFTSKDKFDSQCGWPSFTKPIEEEVEEKLDTSHGMIRTEVRSRTADSHLGHV FNDGPGPNGLRYCINSAALRFVPKHKLKEEGYESYLHLFNK*" /label="msrB CDS" gene complement(1880243..1880674) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /label="msrB gene" downshifts complement(1880248) /Source="Nicolas_upshifts" /id="D1135" /incds=0 /nref=229 /ntot=262 /MaxReadThrough="2.46559" /MaxDrop="6.77483" /score="1.42817565" /energy="-12.3" /TU="NA" /idTUdmin="U1704" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(1880675..1881208) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /EC_number="1.8.4.11" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9573155, 16803968, 17062561, 18662407" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573155, 16803968, 17062561, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine S-sulfoxide reductase" /protein_id="NP_390052.1" /db_xref="EnsemblGenomes-Gn:BSU21690" /db_xref="EnsemblGenomes-Tr:CAB14087" /db_xref="GOA:P54154" /db_xref="InterPro:IPR002569" /db_xref="InterPro:IPR036509" /db_xref="SubtiList:BG11627" /db_xref="UniProtKB/Swiss-Prot:P54154" /translation="MSEKKEIATFAGGCFWCMVKPFDEQPGIEKVVSGYTGGHTENPT YEEVCSETTGHREAVQITFHPDVFPYEKLLELFWQQIDPTDAGGQFADRGSSYRAAIF YHNDKQKELAEASKQRLAESGIFKDPIVTDILKAEPFYEAEGYHQHFYKKNPAHYQRY RTGSGRAGFISEHWGAK*" /label="msrA CDS" gene complement(1880675..1881208) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /label="msrA gene" promotor_-35 1881212..1881218 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1881229..1881339 /Source="Nicolas_S_feature" /locus_tag="new_2288083_2288193" /HighExp="B60, Lbstat, Cold, M9-stat, T4.0H, LoTm, S0, T3.30H, BC, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S817" upshifts 1881229 /Source="Nicolas_upshifts" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1881231..1881250 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1881236..1881255) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1881256) /Source="Nicolas_upshifts" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1881271..1881272) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1881340..1881765 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9571784, 10809700; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_390053.1" /db_xref="EnsemblGenomes-Gn:BSU21700" /db_xref="EnsemblGenomes-Tr:CAB14088" /db_xref="GOA:P54182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11626" /db_xref="UniProtKB/Swiss-Prot:P54182" /translation="MKVRTQMMYDMETLLRKVFKQIRNEINEILDKELSRNEFTILRI LSEQGPKKVTEFAPILEVSASHITAVTDALVEKEWITRIRSKEDRRIIRIHITEAGEK VLQHFNEKKTEYFFKRFDCYTDAELATLIELFSKLDKKR*" /label="ypoP CDS" gene 1881340..1881765 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /label="ypoP gene" downshifts 1881753 /Source="Nicolas_upshifts" /id="D1136" /incds=0 /nref=92 /ntot=248 /MaxReadThrough="4.04021" /MaxDrop="5.35086" /score="-1.90494373" /energy="-7" /TU="U1703" /idTUdmin="U1703" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature 1881798..1883029 /Source="Nicolas_S_feature" /locus_tag="new_2288652_2289883" /HighExp="Cold, ferm, nit, C30, S0, Lbstat, T3.30H, T-4.40H, T5.0H, G135" /AntisenseName="dinF" /AntisenseCor="0.270994122332881" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S818" CDS complement(1881815..1883152) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11583854, 15849754, 16850406, 22933559, 26246409; Product type t : transporter" /codon_start=1 /transl_table=11 /product="damage inducible, Na+ driven multidrug efflux pump" /protein_id="NP_390054.1" /db_xref="EnsemblGenomes-Gn:BSU21710" /db_xref="EnsemblGenomes-Tr:CAB14089" /db_xref="GOA:P54181" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG11625" /db_xref="UniProtKB/Swiss-Prot:P54181" /translation="MKAYDFTQGNVLKQLVLFSMPIMLGNALQVSFQFIDSLWIGNLL GAKALGAAAVSSTIVLTVLSFILGLNNATLTILSQQKGKDDIKGMASYINAFVVLLTG LSIGFGAAGFFLSELLLRLLKTPESMIPLAETYLQIQFIGILFLFGYNFISTVLRALG DSKTPLRFIAFAVVLNTVLAPLFISVFRMGIAGAAYSTILSQGIAFLYGLFYVIKHKL VPFSIPRMPKWEESALILKLGIPAGLQMMVITGGMMAIMSVVNSYGDHVVSGFGAVQR LDSIITLPAMAAGTAVNSMAGQNIGIGNEKRVGTIARLGVIAVISCMLVIAVMIWVFG KYLIRLFISEPDAVAFGEQYLKWIAFFYPFIGVNFVLNGIVRAAGAMLQVLVLNLISF WVLRYPFTALFSAWLGQKGIGLGIGMSFLFSSCAAFLYYRYGRWKAMKLFTEK*" /label="dinF CDS" gene complement(1881815..1883152) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /label="dinF gene" CDS complement(1883224..1883418) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390055.1" /db_xref="EnsemblGenomes-Gn:BSU21720" /db_xref="EnsemblGenomes-Tr:CAB14090" /db_xref="GOA:P54180" /db_xref="InterPro:IPR035403" /db_xref="SubtiList:BG11624" /db_xref="UniProtKB/Swiss-Prot:P54180" /translation="MKRIYQYFSLLSFTFSLYFGWLAYHHLAAEDMDQMYLNVSYCAL FLSVMVFTFGMRDRKKTDKS*" /label="ypmT CDS" gene complement(1883224..1883418) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /label="ypmT gene" downshifts complement(1883237) /Source="Nicolas_upshifts" /id="D1137" /incds=0 /nref=123 /ntot=248 /MaxReadThrough="3.84998" /MaxDrop="4.80224" /score="-2.26655222" /energy="-15.5" /TU="U1705" /idTUdmin="U1707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1883431..1883994) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390056.1" /db_xref="EnsemblGenomes-Gn:BSU21730" /db_xref="EnsemblGenomes-Tr:CAB14091" /db_xref="GOA:P54179" /db_xref="InterPro:IPR018672" /db_xref="SubtiList:BG11623" /db_xref="UniProtKB/Swiss-Prot:P54179" /translation="MNKWKRLFFILLAINFILAAGFVALVLLPGEQAQVKDASESEYG FQVTSTKESLAAFVNSYLNDKASNKLDYKVEIDDDVHVAGKIKAFSTSIDAFIAFEPT VKKNGDVELNVTKFSLGKLSIPISFVLNYMDSFYELPSFVHVHPGDKSIEVRLSEMPL TNGMYVKADKINLEKDEIEFSYYHPKQ*" /label="ypmS CDS" gene complement(1883431..1883994) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /label="ypmS gene" CDS complement(1884004..1884771) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17220230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported lipase/acylhydrolase (lipoprotein)" /protein_id="NP_390057.1" /db_xref="EnsemblGenomes-Gn:BSU21740" /db_xref="EnsemblGenomes-Tr:CAB14092" /db_xref="GOA:P40766" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11022" /db_xref="UniProtKB/Swiss-Prot:P40766" /translation="MKLRIFSIMASLILLLTACTSIRTSSEGKQKAHETKTKEHIVIA AVGDSLTEGVGDPDGKGYVGKVADSIRSDKQVKTVDVKNYAVKGNRSDDLLEKLKDKK VQKGIKDADYVFFTIGGNDLMKILRQNFLQLTVEPFQEAEKPYEKRFEKIISEIRELN DHAELIYVSMYNPFTFTLSELNEINGVVTDWNHIAEKELKKDKHAKIVHIEDLFNQKS DSSRISEEDDFHPNGTGYSLIAKRVYQAIKKEGLPKE*" /label="ypmR CDS" gene complement(1884004..1884771) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /label="ypmR gene" promotor_-10 complement(1884795..1884814) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1884812) /Source="Nicolas_upshifts" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1884825..1884832) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1884849..1885430) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10837475, 14680962, 14766920, 16305244, 19027886, 29131589" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10837475, 14680962, 14766920, 16305244, 19027886, 29131589; Product type f : factor" /codon_start=1 /transl_table=11 /product="assembly factor BSco of the Cu(A) site of cytochrome c oxidase" /protein_id="NP_390058.2" /db_xref="EnsemblGenomes-Gn:BSU21750" /db_xref="EnsemblGenomes-Tr:CAB14093" /db_xref="GOA:P54178" /db_xref="InterPro:IPR003782" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ON4" /db_xref="PDB:1XZO" /db_xref="SubtiList:BG11622" /db_xref="UniProtKB/Swiss-Prot:P54178" /translation="MKVIKGLTAGLIFLFLCACGGQQIKDPLNYEVEPFTFQNQDGKN VSLESLKGEVWLADFIFTNCETICPPMTAHMTDLQKKLKAENIDVRIISFSVDPENDK PKQLKKFAANYPLSFDNWDFLTGYSQSEIEEFALKSFKAIVKKPEGEDQVIHQSSFYL VGPDGKVLKDYNGVENTPYDDIISDVKSASTLK*" /label="scuA CDS" gene complement(1884849..1885430) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /label="scuA gene" S_feature complement(1885431..1885546) /Source="Nicolas_S_feature" /locus_tag="new_2292285_2292400_c" /HighExp="T5.0H, T3.30H, S2, T3.0H, BC, T2.30H, T4.0H, S1, HiOs, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S819" CDS complement(1885578..1885829) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15060025, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390059.1" /db_xref="EnsemblGenomes-Gn:BSU21760" /db_xref="EnsemblGenomes-Tr:CAB14094" /db_xref="InterPro:IPR019687" /db_xref="SubtiList:BG11621" /db_xref="UniProtKB/Swiss-Prot:P54177" /translation="MLLKSLEFKRGDGIQVKVTEIPVLKEDEHYFFMLHHHLQFYLKE VFSSNSRAKVYSFRHYMKRRMKWADYQAVFHQEVLKHNA*" /label="ypmP CDS" gene complement(1885578..1885829) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /label="ypmP gene" downshifts complement(1885591) /Source="Nicolas_upshifts" /id="D1138" /incds=0 /nref=2 /ntot=117 /MaxReadThrough="4.5803" /MaxDrop="2.91481" /score="26.0320926" /energy="-21.8" /TU="U1707" /idTUdmin="U1706" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1885852..1885871) /Source="Nicolas_upshift_promotors" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1885866) /Source="Nicolas_upshifts" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1885915..1887183) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /EC_number="4.3.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine dehydratase" /protein_id="NP_390060.1" /db_xref="EnsemblGenomes-Gn:BSU21770" /db_xref="EnsemblGenomes-Tr:CAB14095" /db_xref="GOA:P37946" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001721" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011820" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10673" /db_xref="UniProtKB/Swiss-Prot:P37946" /translation="MKPLLKENSLIQVKDILKAHQNVKDVVIHTPLQRNDRLSERYEC NIYLKREDLQVVRSFKLRGAYHKMKQLSSEQTENGVVCASAGNHAQGVAFSCKHLGIH GKIFMPSTTPRQKVSQVELFGKGFIDIILTGDTFDDAYKSAAECCEAESRTFIHPFDD PDVMAGQGTLAVEILNDIDTEPHFLFASVGGGGLLSGVGTYLKNVSPDTKVIAVEPAG AASYFESNKAGHVVTLDKIDKFVDGAAVKKIGEETFRTLETVVDDILLVPEGKVCTSI LELYNECAVVAEPAGALSVAALDLYKDQIKGKNVVCVVSGGNNDIGRMQEMKERSLIF EGLQHYFIVNFPQRAGALREFLDEVLGPNDDITRFEYTKKNNKSNGPALVGIELQNKA DYGPLIERMNKKPFHYVEVNKDEDLFHLLI*" /label="ilvA CDS" gene complement(1885915..1887183) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /label="ilvA gene" promotor_-10 complement(1887217..1887236) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1887236) /Source="Nicolas_upshifts" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1887248..1887255) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1887390..1887409 /Source="Nicolas_upshift_promotors" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1887393 /Source="Nicolas_upshifts" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="upshifts" CDS 1887432..1888427 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12399512, 16585774, 19763274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399512, 16585774, 19763274; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional enhancer involved in BCAA homeostasis" /protein_id="NP_390061.1" /db_xref="EnsemblGenomes-Gn:BSU21780" /db_xref="EnsemblGenomes-Tr:CAB14096" /db_xref="GOA:P54156" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013668" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11619" /db_xref="UniProtKB/Swiss-Prot:P54156" /translation="MNSAPKLNTFQHLIGEHQTFLEAKRIAKQFSLSELPVLITGKIG TGKNHFAHAIHLESSRSNEPFISVNCSTHSEETLIHELFGPNGNTGVFQKAVRGTLFL DDVWRMPASVQAQLLKALDSDTEKPRMICASADRSVEHTFRQDLFYRLNILTLTLPEL SERKSDIPLLTQHFLSNSGQQLLIDPSVFPVLEKHAFEGNVRELKNAADYMAAVSSGG TIQPYDLPPYIRGTIDGKTSKKKAKLLTLMEKAEFLFILETIKVLNEKGEPASRRIIS EHSKNTQTSLTPQQVRSRLDYLEKKDYVTKSRGRAGTKITFEGLSFIETLKNQMI*" /label="silP CDS" gene 1887432..1888427 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /label="silP gene" CDS 1888448..1889089 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16585774, 16850406, 19763274; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_390062.1" /db_xref="EnsemblGenomes-Gn:BSU21790" /db_xref="EnsemblGenomes-Tr:CAB14097" /db_xref="GOA:P54175" /db_xref="InterPro:IPR004254" /db_xref="InterPro:IPR005744" /db_xref="SubtiList:BG11620" /db_xref="UniProtKB/Swiss-Prot:P54175" /translation="MFTIKEEIANAITHGIGVLLSIPALVFLIIFAANYGSAWDIVSF TIFGVSMLLLYLSSTLLHSITHKKTKDILEIIDHSAIYVLIAGTYTPFLLGPLKGTLG FTLLVIVWSLALGGIVFKIFFVKRFILLSTFVYLVMGWLMIIAVKPLYASLSGAGFSL LFLGGILYSVGTIFYIWKKIPFHHAIWHSFVLGGSAAMFFCVLFYCVKVPFLS*" /label="yplQ CDS" gene 1888448..1889089 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /label="yplQ gene" S_feature 1889090..1890191 /Source="Nicolas_S_feature" /locus_tag="new_2295944_2297045" /HighExp="Cold, C30, Sw, BC, G135, LoTm, Fru, C90, BI, S0" /AntisenseName="ypkP" /AntisenseCor="0.28434605181220002" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S820" CDS complement(1889128..1889748) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 1-acyl-sn-glycerol-3-phosphate acyltransferase" /protein_id="NP_390063.2" /db_xref="EnsemblGenomes-Gn:BSU21800" /db_xref="EnsemblGenomes-Tr:CAB14098" /db_xref="SubtiList:BG11618" /db_xref="UniProtKB/Swiss-Prot:P54174" /translation="MVRYSLLVVYIVYMLLKNMKQLFNQTMLDPRLSYKKQMALVYEQ PKAFLEGCIGISGSVVTIHQPEPIPHGPVLYVHPRLRLAELALIAGYIEEPAGFIANP KVFRLPFIGQWLDRMDVISDGDSEKVYEDVTKQLEKGQSLILSLDGSIDPVELAARYH LPLVMVETKGTDNMQNGSFFKRLKPADIELSFSKAYIPANEKQLRA*" /label="ypkP CDS" gene complement(1889128..1889748) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /label="ypkP gene" downshifts complement(1889154) /Source="Nicolas_upshifts" /id="D1139" /incds=0 /nref=72 /ntot=241 /MaxReadThrough="1.32187" /MaxDrop="5.02823" /score="16.0584527" /energy="-13.4" /TU="NA" /idTUdmin="U1710" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1889749..1890255) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /EC_number="1.5.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2840350, 3918568, 10574451, 12682299, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2840350, 3918568, 10574451, 12682299, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydrofolate reductase" /protein_id="NP_390064.1" /db_xref="EnsemblGenomes-Gn:BSU21810" /db_xref="EnsemblGenomes-Tr:CAB14099" /db_xref="GOA:P11045" /db_xref="InterPro:IPR001796" /db_xref="InterPro:IPR012259" /db_xref="InterPro:IPR017925" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG10795" /db_xref="UniProtKB/Swiss-Prot:P11045" /translation="MISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKITSGHSIIMGR KTFESIGRPLPNRKNIVVTSAPDSEFQGCTVVSSLKDVLDICSGPEECFVIGGAQLYT DLFPYADRLYMTKIHHEFEGDRHFPEFDESNWKLVSSEQGTKDEKNPYDYEFLMYEKK NSSKAGGF*" /label="dfrA CDS" gene complement(1889749..1890255) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /label="dfrA gene" CDS complement(1890252..1891046) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9648749, 10574451, 19732150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9648749, 10574451, 19732150; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase B" /protein_id="NP_390065.1" /db_xref="EnsemblGenomes-Gn:BSU21820" /db_xref="EnsemblGenomes-Tr:CAB14100" /db_xref="GOA:P11044" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="SubtiList:BG10794" /db_xref="UniProtKB/Swiss-Prot:P11044" /translation="MKQYKDFCRHVLEHGEKKGDRTGTGTISTFGYQMRFNLREGFPM LTTKKLHFKSIAHELLWFLKGDTNVRYLQENGVRIWNEWADENGELGPVYGSQWRSWR GADGETIDQISRLIEDIKTNPNSRRLIVSAWNVGEIDKMALPPCHCLFQFYVSDGKLS CQLYQRSADVFLGVPFNIASYALLTMIIAHVTGLEPGEFIHTFGDVHIYQNHIEQVNL QLERDVRPLPQLRFARKVDSIFNFAFEDFIIEDYDPHPHIKGAVSV*" /label="thyB CDS" gene complement(1890252..1891046) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /label="thyB gene" CDS complement(1891130..1891663) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8534098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_390066.1" /db_xref="EnsemblGenomes-Gn:BSU21830" /db_xref="EnsemblGenomes-Tr:CAB14101" /db_xref="GOA:P54173" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="PDB:1TLQ" /db_xref="SubtiList:BG11617" /db_xref="UniProtKB/Swiss-Prot:P54173" /translation="MKKYTMNEMVDITKDMLNKRGVMIEDIARIVQKLQEKYNPNLPL SVCMENVEKVLNKREIIHAVLTGLALDQLAEQKLLPEPLQHLVETDEPLYGIDEIIPL SIVNVYGSIGLTNFGYLDKEKIGIIKELDESPDGIHTFLDDIVAALAAAAASRIAHTH QDLQDEEKEQDEKPVVS*" /label="ypjQ CDS" gene complement(1891130..1891663) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /label="ypjQ gene" downshifts complement(1891135) /Source="Nicolas_upshifts" /id="D1140" /incds=0 /nref=17 /ntot=167 /MaxReadThrough="4.91561" /MaxDrop="4.18561" /score="15.5758445" /energy="-9.3" /TU="U1710" /idTUdmin="U1711" /TUdmin=1232 /isTUend="FALSE" /label="downshifts" promotor_-35 1891593..1891598 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1891609..1892555 /Source="Nicolas_S_feature" /locus_tag="new_2298463_2299409" /HighExp="S5, S6, S4, S8, S7, S3, B36, BT, B60, T5.0H" /AntisenseName="ypjP" /AntisenseCor="-0.72590712604537599" /AntisenseRegPval="-44.6" /CDS_PredictionProba="0.99932399999999999" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S821" upshifts 1891611 /Source="Nicolas_upshifts" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1891615..1891633 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1891681..1892292) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390067.1" /db_xref="EnsemblGenomes-Gn:BSU21840" /db_xref="EnsemblGenomes-Tr:CAB14102" /db_xref="GOA:P54172" /db_xref="InterPro:IPR025616" /db_xref="SubtiList:BG11616" /db_xref="UniProtKB/Swiss-Prot:P54172" /translation="MKLWMRKTLVVLFTIVTFGLVSPPAALMADKPSGQPSSLEQNDY TAFYDEHDLYDDESDDRRDPELLFQSYKEQLLDSAEDQSFLKFGSRIAPVIEDDYRKE ILPKIENVISDYLATLQDDEAYQDVVISSMPSAGKTEKIFNVYNRTTGEDLLRFHVRR DHPPHDGYWFNFHYHTAEDGFQSHHELGSIYWDRNTPPNWMSA*" /label="ypjP CDS" gene complement(1891681..1892292) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /label="ypjP gene" promotor_-10 complement(1892324..1892343) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1892343) /Source="Nicolas_upshifts" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1892356..1892361) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1892512 /Source="Nicolas_upshifts" /id="D1141" /incds=0 /nref=57 /ntot=234 /MaxReadThrough="3.131" /MaxDrop="5.18613" /score="2.81720493" /energy="-15" /TU="U1709" /idTUdmin="U1709" /TUdmin="-527" /isTUend="FALSE" /label="downshifts" CDS complement(1892552..1893325) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /EC_number="2.1.1.242" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22079366; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 16S rRNA m(2)G1516 methyltransferase" /protein_id="NP_390068.2" /db_xref="EnsemblGenomes-Gn:BSU21850" /db_xref="EnsemblGenomes-Tr:CAB14103" /db_xref="GOA:P54171" /db_xref="InterPro:IPR007536" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11615" /db_xref="UniProtKB/Swiss-Prot:P54171" /translation="MITTSYRPSEHTIKTAKQLSKELNMPYCGRNKQTVEHLLKSAER DLLVVGKERFELYTKQGAKFFFHPNTAMFRAKRFLQGEKEPMLRAAGLSEGDTFLDCT LGLGSDAIIASMAVGETGSVVGIEKNHLVSVLVRTGLHSWETGIEELQAAMRRIQVKN GDCFEHIKQLPDNSVDVVYFDPMFHEPVETSDGIAPLRDLAEDSVLHEGCINEAVRVA RKSVVLKDHWKSPRFEQFGFNVMKRKTALFHYGVIQTSP*" /label="rsmJ CDS" gene complement(1892552..1893325) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /label="rsmJ gene" downshifts complement(1892587) /Source="Nicolas_upshifts" /id="D1142" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="2.86923" /MaxDrop="2.91228" /score="9.10717118" /energy="-15" /TU="U1711" /idTUdmin="U1711" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(1893367..1893801) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19653655, 21749987, 22938038, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19653655, 21749987, 22938038, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein disulfide isomerase; bacilliredoxin A (de-bacillithiolation)" /protein_id="NP_390069.1" /db_xref="EnsemblGenomes-Gn:BSU21860" /db_xref="EnsemblGenomes-Tr:CAB14104" /db_xref="InterPro:IPR009474" /db_xref="PDB:3FHK" /db_xref="SubtiList:BG11614" /db_xref="UniProtKB/Swiss-Prot:P54170" /translation="MSMAYEEYMRQLVVPMRRELTGAGFEELTTAEEVENFMEKAEGT TLVVVNSVCGCAAGLARPAATQAVLQNDKTPDNTVTVFAGQDKEATAKMREYFTGQEP SSPSMALLKGKEVVHFIPRHEIEGHDMEEIMKNLTAAFDAHC*" /label="brxA CDS" gene complement(1893367..1893801) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /label="brxA gene" downshifts complement(1893379) /Source="Nicolas_upshifts" /id="D1143" /incds=0 /nref=9 /ntot=210 /MaxReadThrough="5.2935" /MaxDrop="3.1992" /score="21.0933404" /energy="-9.7" /TU="U1711,U1712" /idTUdmin="U1712" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1893830..1893849) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-10" upshifts complement(1893841) /Source="Nicolas_upshifts" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="upshifts" S_feature complement(1893843..1893907) /Source="Nicolas_S_feature" /locus_tag="new_2300697_2300761_c" /HighExp="Sw, S1, BC, Gly, HiOs, HiTm, GM-0.1, UNK1, Fru, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S822" promotor_-35 complement(1893863..1893870) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-35" downshifts complement(1893886) /Source="Nicolas_upshifts" /id="D1144" /incds=0 /nref=32 /ntot=128 /MaxReadThrough="5.73826" /MaxDrop="4.95094" /score="26.9702838" /energy="-25.8" /TU="U1712" /idTUdmin="U1713" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1893908..1895584) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /EC_number="4.2.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12193635, 12618455, 15060025, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193635, 12618455, 15060025, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxy-acid dehydratase" /protein_id="NP_390070.2" /db_xref="EnsemblGenomes-Gn:BSU21870" /db_xref="EnsemblGenomes-Tr:CAB14105" /db_xref="GOA:P51785" /db_xref="InterPro:IPR000581" /db_xref="InterPro:IPR004404" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR020558" /db_xref="SubtiList:BG11532" /db_xref="UniProtKB/Swiss-Prot:P51785" /translation="MAELRSNMITQGIDRAPHRSLLRAAGVKEEDFGKPFIAVCNSYI DIVPGHVHLQEFGKIVKEAIREAGGVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIAD SVETVVSAHWFDGMVCIPNCDKITPGMLMAAMRINIPTIFVSGGPMAAGRTSDGRKIS LSSVFEGVGAYQAGKINENELQELEQFGCPTCGSCSGMFTANSMNCLSEALGLALPGN GTILATSPERKEFVRKSAAQLMETIRKDIKPRDIVTVKAIDNAFALDMALGGSTNTVL HTLALANEAGVEYSLERINEVAERVPHLAKLAPASDVFIEDLHEAGGVSAALNELSKK EGALHLDALTVTGKTLGETIAGHEVKDYDVIHPLDQPFTEKGGLAVLFGNLAPDGAII KTGGVQNGITRHEGPAVVFDSQDEALDGIINRKVKEGDVVIIRYEGPKGGPGMPEMLA PTSQIVGMGLGPKVALITDGRFSGASRGLSIGHVSPEAAEGGPLAFVENGDHIIVDIE KRILDVQVPEEEWEKRKANWKGFEPKVKTGYLARYSKLVTSANTGGIMKI*" /label="ilvD CDS" gene complement(1893908..1895584) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /label="ilvD gene" S_feature complement(1895585..1895775) /Source="Nicolas_S_feature" /locus_tag="new_2302439_2302629_c" /HighExp="S1, T-5.40H, MG 45, HiOs, T-4.40H, MG 120, UNK1, MG 25, MG-0.2, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.97" /TUlongSig="SigH" /TUlongPSig=1 /label="S823" promotor_-10 complement(1895764..1895783) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1895775) /Source="Nicolas_upshifts" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1895798..1895801) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1895873..1897006) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase or scaffold" /protein_id="NP_390071.1" /db_xref="EnsemblGenomes-Gn:BSU21880" /db_xref="EnsemblGenomes-Tr:CAB14106" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR014824" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR025989" /db_xref="InterPro:IPR036498" /db_xref="SubtiList:BG11613" /db_xref="UniProtKB/Swiss-Prot:P54169" /translation="MKIKSIEPTPSPNTMKVILTEELPAGKSNNYKPEQAEGAPLVIA EILKIDGVKGVYHVADFLAVERNARYDWKDILPQVRTAFGMESAESAEENRSDQESFG EVKVFVQMFSGIPMQVKLTDGEREERFGLPERFQQAILKLRSEASNVVFERAWKEQGV RFGDFDEIGHDVTEELQAAYSDERLKRLTEAAAQGKGEAKQAVQRKAYKVTLDMLDDE DWKKRYAHLEQMDPKEEDIPVLQKALDDPKVSIRRQAVVYLGMIETPDVLPLLYKALE DKAVSVRRTAGDCLSDIGDPQAIPAMIKSLSDSSKLVRWRAAMFLYEVGDESAIEALR AAEDDPEFEVSLQVKMALERIEHGEEAKGSVWKQMTESRKKGE*" /label="ypgR CDS" gene complement(1895873..1897006) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /label="ypgR gene" downshifts complement(1895889) /Source="Nicolas_upshifts" /id="D1145" /incds=0 /nref=193 /ntot=249 /MaxReadThrough="5.33526" /MaxDrop="6.88149" /score="18.2078317" /energy="-8.7" /TU="U1713" /idTUdmin="U1714" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" misc_feature complement(1897028..1897047) /Source="Nicolas_upshift_promotors" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1897031) /Source="Nicolas_upshifts" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1897066..1897683) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /EC_number="3.6.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25005104, 27062940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25005104, 27062940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Mn(2+)-dependent (deoxy)ribonucleoside pyrophosphohydrolase" /protein_id="NP_390072.1" /db_xref="EnsemblGenomes-Gn:BSU21890" /db_xref="EnsemblGenomes-Tr:CAB14107" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11612" /db_xref="UniProtKB/Swiss-Prot:P54168" /translation="MKELKQAEQIRTWVQSILTDESSGHDWHHVSRVADLAAYIGEKE KADLFIVETAALVHDLIDVKLPDTVRLSVSEVYDQLVFFGVGKENADRVIHIITRMSF RDRGKLAKEPLSIEGKAVQDADRLDAIGAVGIARAFMFAGAKGHGLYGDEQSAYAHFF HKLLRLKDMMNTDTARELAEERHNFMLQFVRQLEKDIPGIDAETS*" /label="hdhQ CDS" gene complement(1897066..1897683) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /label="hdhQ gene" CDS complement(1897699..1898181) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /EC_number="1.11.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14563871, 14617062, 21749987, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol peroxidase" /protein_id="NP_390073.1" /db_xref="EnsemblGenomes-Gn:BSU21900" /db_xref="EnsemblGenomes-Tr:CAB14108" /db_xref="GOA:P52035" /db_xref="InterPro:IPR000889" /db_xref="InterPro:IPR029759" /db_xref="InterPro:IPR029760" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11530" /db_xref="UniProtKB/Swiss-Prot:P52035" /translation="MSIYHMKVRTITGKDMTLQPFAGKVLMIVNTASKCGFTSQLKQL QELYDTYQQEGLEILGFPCNQFMNQEPGEEADIQEFCETNYGVTFPMFSKVDVNGKNA HPLFVYLTEHAKGMLGTKAIKWNFTKFIVDRNGEIVGRYSPNTNPKELEDDIVKLLEQ *" /label="bsaA CDS" gene complement(1897699..1898181) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /label="bsaA gene" S_feature complement(1898182..1898329) /Source="Nicolas_S_feature" /locus_tag="new_2305036_2305183_c" /HighExp="S2, HiOs, S1, Etha, T2.30H, T3.0H, Lbtran, M0t90, T2.0H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S824" promotor_-10 complement(1898320..1898338) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-10" upshifts complement(1898330) /Source="Nicolas_upshifts" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="upshifts" promotor_-35 complement(1898349..1898357) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-35" promotor_-35 1898383..1898392 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 1898405..1898420 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" S_feature 1898407..1898493 /Source="Nicolas_S_feature" /locus_tag="new_2305261_2305347" /HighExp="Salt, T-0.40H, T-1.10H, Heat, T-1.40H, H2O2, T0.0H, Paraq, T0.30H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S825" upshifts 1898407 /Source="Nicolas_upshifts" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" promotor_-35 1898456..1898463 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 1898478..1898497 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" upshifts 1898495 /Source="Nicolas_upshifts" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" CDS 1898524..1899429 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /EC_number="2.3.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5001847, 10939241, 11832514, 17056751, 18216013, 28581482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5001847, 10939241, 11832514, 17056751, 18216013, 28581482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="homoserine O-acetyltransferase" /protein_id="NP_390074.2" /db_xref="EnsemblGenomes-Gn:BSU21910" /db_xref="EnsemblGenomes-Tr:CAB14109" /db_xref="GOA:P54167" /db_xref="InterPro:IPR005697" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033752" /db_xref="SubtiList:BG11534" /db_xref="UniProtKB/Swiss-Prot:P54167" /translation="MPINIPTHLPAKQVLESEHIFVMDESRAFHQDIRPQKIIILNLM PKKIQTETQLLRLLGNSPLQVHFTFLIPSTHTPKNTAREHLDEFYTTFSNIRHKRFDG MIITGAPIEHLAFEEVSYWEELKEIMEWSKTNVTSTLHICWGAQAGLYYHYGVEKIQM PKKIFGVFEHTVLSKHERLVRGFDELYYVPHSRHTDINMEQLQAVPELNILTASKEAG VCLIVSKDEKQVFLTGHPEYDTNTLLQEYERDLERNLSTVEAPKHYFAKGSNEPVNRW KAHATLLFMNWLNYYVYQETPYEWD*" /label="metAA CDS" gene 1898524..1899429 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /label="metAA gene" misc_feature 1899464..1899483 /Source="Nicolas_upshift_promotors" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1899478 /Source="Nicolas_upshifts" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" S_feature 1899479..1899659 /Source="Nicolas_S_feature" /locus_tag="new_2306333_2306513" /HighExp="Heat, HiTm, LoTm, C90, M9-stat, HiOs, SMM, UNK1, MG 25, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="0.999, 0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S826" CDS 1899660..1900808 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /EC_number="2.4.1.315" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose diacylglyceroltransferase" /protein_id="NP_390075.1" /db_xref="EnsemblGenomes-Gn:BSU21920" /db_xref="EnsemblGenomes-Tr:CAB14110" /db_xref="GOA:P54166" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR009695" /db_xref="InterPro:IPR023589" /db_xref="SubtiList:BG11611" /db_xref="UniProtKB/Swiss-Prot:P54166" /translation="MNTNKRVLILTANYGNGHVQVAKTLYEQCVRLGFQHVTVSNLYQ ESNPIVSEVTQYLYLKSFSIGKQFYRLFYYGVDKIYNKRKFNIYFKMGNKRLGELVDE HQPDIIINTFPMIVVPEYRRRTGRVIPTFNVMTDFCLHKIWVHENVDKYYVATDYVKE KLLEIGTHPSNVKITGIPIRPQFEESMPVGPIYKKYNLSPNKKVLLIMAGAHGVLKNV KELCENLVKDDQVQVVVVCGKNTALKESLSALEAENGDKLKVLGYVERIDELFRITDC MITKPGGITLTEATAIGVPVILYKPVPGQEKENANFFEDRGAAIVVNRHEEILESVTS LLADEDTLHRMKKNIKDLHLANSSEVILEDILKESEMMTAKQKAKVLS*" /label="ugtP CDS" gene 1899660..1900808 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /label="ugtP gene" S_feature complement(1899829..1900858) /Source="Nicolas_S_feature" /locus_tag="new_2306683_2307712_c" /HighExp="S8, S7, S6, C30, Lbstat, T0.30H, C90, BT, G135, Fru" /AntisenseName="ugtP" /AntisenseCor="-0.328222465122327" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S827" downshifts 1900804 /Source="Nicolas_upshifts" /id="D1146" /incds=0 /nref=77 /ntot=240 /MaxReadThrough="4.0787" /MaxDrop="4.20549" /score="21.6989702" /energy="-12.1" /TU="U1715,U1717" /idTUdmin="U1716" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1900840..1900859) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1900858) /Source="Nicolas_upshifts" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1900874..1900882) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1900889..1901035 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513973.1" /translation="MELALLLKNKPFRNLTGAPRWCIVEPSFNNESKLDDDKIFFSTW VLQY*" /label="hypothetical protein CDS" gene 1900889..1901035 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /label="gene" promotor_-35 1900928..1900935 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1900949..1900968 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1900960..1901050 /Source="Nicolas_S_feature" /locus_tag="new_2307814_2307904" /HighExp="C90, T5.0H, T3.30H, T3.0H, HiOs, Salt, LoTm, T-3.40H, S3, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S828" upshifts 1900960 /Source="Nicolas_upshifts" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="upshifts" CDS 1901051..1901251 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9920884, 16352840" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9920884, 16352840; Product type f: factor" /codon_start=1 /transl_table=11 /product="cold-shock protein, molecular chaperone, RNA-helicase co-factor" /protein_id="NP_390076.1" /db_xref="EnsemblGenomes-Gn:BSU21930" /db_xref="EnsemblGenomes-Tr:CAB14111" /db_xref="GOA:P51777" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11531" /db_xref="UniProtKB/Swiss-Prot:P51777" /translation="MQNGKVKWFNNEKGFGFIEVEGGDDVFVHFTAIEGDGYKSLEEG QEVSFEIVEGNRGPQASNVVKL*" /label="cspD CDS" gene 1901051..1901251 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /label="cspD gene" downshifts 1901266 /Source="Nicolas_upshifts" /id="D1147" /incds=0 /nref=257 /ntot=269 /MaxReadThrough="5.19931" /MaxDrop="8.09346" /score="9.24662311" /energy="-15.6" /TU="U1719" /idTUdmin="U1715" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS complement(1901303..1901485) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16625836, 19251843, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16625836, 19251843, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of degradative enzymes (aprE, nprE, sacB) production or activity" /protein_id="NP_390077.1" /db_xref="EnsemblGenomes-Gn:BSU21940" /db_xref="EnsemblGenomes-Tr:CAB14112" /db_xref="GOA:P68731" /db_xref="SubtiList:BG10699" /db_xref="UniProtKB/Swiss-Prot:P68731" /translation="MDDKDLKLILHKTFIEIYSDLEELADIAKKGKPSMEKYVEEIEQ RCKQNILAIEIQMKIK*" /label="degR CDS" gene complement(1901303..1901485) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /label="degR gene" S_feature 1901311..1901616 /Source="Nicolas_S_feature" /locus_tag="new_2308165_2308470" /HighExp="Cold, LoTm, T4.0H, T3.30H, Pyr, T5.0H, Gly, T3.0H, S0, C30" /AntisenseName="degR" /AntisenseCor="-0.145220711637392" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S829" downshifts complement(1901320) /Source="Nicolas_upshifts" /id="D1148" /incds=0 /nref=133 /ntot=216 /MaxReadThrough="3.75638" /MaxDrop="5.32427" /score="16.1392275" /energy="-7.3" /TU="U1720" /idTUdmin="U1720" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1901546..1901564) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1901578..1901584) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1901582) /Source="Nicolas_upshifts" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1901592..1901598 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1901613..1901624 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1901618 /Source="Nicolas_upshifts" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="upshifts" CDS 1901641..1901910 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390078.1" /db_xref="EnsemblGenomes-Gn:BSU21950" /db_xref="EnsemblGenomes-Tr:CAB14113" /db_xref="InterPro:IPR020314" /db_xref="SubtiList:BG13764" /db_xref="UniProtKB/Swiss-Prot:O32007" /translation="MTSEFHNEDQTGFTDKRQLELAVETAQKTTGAATRGQSKTLVDS AYQAIEDARELSQSEELAALDDPEFVKQQQQLLDDSEHQLDEFKE*" /label="ypzA CDS" gene 1901641..1901910 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /label="ypzA gene" downshifts 1901765 /Source="Nicolas_upshifts" /id="D1149" /incds=1 /nref=3 /ntot=82 /MaxReadThrough="6.79633" /MaxDrop="4.11501" /score="22.0113838" /energy="-7.3" /TU="U1719,U1721" /idTUdmin="U1719" /TUdmin="-117" /isTUend="FALSE" /label="downshifts" downshifts 1901893 /Source="Nicolas_upshifts" /id="D1150" /incds=0 /nref=18 /ntot=94 /MaxReadThrough="2.31821" /MaxDrop="6.65627" /score="22.0113838" /energy="-7.3" /TU="NA" /idTUdmin="U1719" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(1901938..1902120) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390079.1" /db_xref="EnsemblGenomes-Gn:BSU21960" /db_xref="EnsemblGenomes-Tr:CAB14114" /db_xref="InterPro:IPR019718" /db_xref="SubtiList:BG11610" /db_xref="UniProtKB/Swiss-Prot:P54165" /translation="MDKKMIFKELTELHDEYCKDCFIKKQFRKEFGKTYAHSFCINKC TVGEKLKQYGDVLTNH*" /label="ypeQ CDS" gene complement(1901938..1902120) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /label="ypeQ gene" downshifts complement(1901958) /Source="Nicolas_upshifts" /id="D1151" /incds=0 /nref=5 /ntot=102 /MaxReadThrough="2.77117" /MaxDrop="4.29218" /score="16.1392275" /energy="-7.3" /TU="NA" /idTUdmin="U1723" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1902113..1902793) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12562816, 17905985, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 17905985, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease" /protein_id="NP_390080.2" /db_xref="EnsemblGenomes-Gn:BSU21970" /db_xref="EnsemblGenomes-Tr:CAB14115" /db_xref="GOA:P54164" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11609" /db_xref="UniProtKB/Swiss-Prot:P54164" /translation="MKLRPHLKIEAKGTGSVSFFSEDWLTAQQARTFARELGRFPYMK ELEFEDEKGGSWTLKELEKLTEELAQEPDDITVYFDGSFDKESELAGLGIVIYYSLGG TRHRLRKNKSFRLKTNNEAEYAALYEAIREVRELGASRNSITIKGDSLVVLNQLDGSW PCYDPSHNEWLDKIEALLESLKLTPTYETIQRKDNQEADGLAKKILSHQFVESHTKLD RNGDDDIG*" /label="ypeP CDS" gene complement(1902113..1902793) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /label="ypeP gene" S_feature complement(1902794..1902931) /Source="Nicolas_S_feature" /locus_tag="new_2309648_2309785_c" /HighExp="S5, S4, S6, S8, S7, S3, T5.0H, T4.0H, BT, Pyr" /AntisenseName="ypdP" /AntisenseCor="-0.65324924042743404" /AntisenseRegPval="-33.4" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.92, 0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S830" promotor_-35 1902810..1902815 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1902828..1902847 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1902833 /Source="Nicolas_upshifts" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="upshifts" CDS 1902876..1903565 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28208705; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preQ0 transporter (promiscuous)" /protein_id="NP_390081.1" /db_xref="EnsemblGenomes-Gn:BSU21980" /db_xref="EnsemblGenomes-Tr:CAB14116" /db_xref="GOA:P54163" /db_xref="InterPro:IPR003744" /db_xref="SubtiList:BG11607" /db_xref="UniProtKB/Swiss-Prot:P54163" /translation="MFNNSFWIFFAIIHFIIVLLFYKGFGKMGLFVWIGFATVCANLQ VVKTVELFGLTATLGNVMYGTIFFATDVLNEKYGPAEARKAVWLGFSTLLTLTFVMQG VLLFEPASSDISQTALETIFGFLPRVALGSLLAFIFSQTLDVYVYSAIRRIFPSDRLL WLRNGGSTAVSQLFDTFIFTAVAFLGIYPADVWLHIFISTYLIKFAVSLISLPYAYAA KKMIPNDERSS*" /label="queP CDS" gene 1902876..1903565 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /label="queP gene" promotor_-35 complement(1902929..1902945) /Source="Nicolas_upshift_promotors" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1902932) /Source="Nicolas_upshifts" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1902933..1903322) /Source="Nicolas_S_feature" /locus_tag="new_2309787_2310176_c" /HighExp="S5, S4, S6, S7, S8, T5.0H, S3, T4.0H, BT, M9-stat" /AntisenseName="ypdP" /AntisenseCor="-0.645700204826543" /AntisenseRegPval="-32.4" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S831" promotor_-10 complement(1903303..1903322) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1903320) /Source="Nicolas_upshifts" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1903334..1903342) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1903565..1903963 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9888800, 10094689, 15115438, 17905985; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein (no RNase H activity)" /protein_id="NP_390082.1" /db_xref="EnsemblGenomes-Gn:BSU21990" /db_xref="EnsemblGenomes-Tr:CAB14117" /db_xref="GOA:P54162" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11608" /db_xref="UniProtKB/Swiss-Prot:P54162" /translation="MPTEIYVDGASAGNPGPSGIGIFIKHEGKAESFSIPIGVHTNQE AEFLALIEGMKLCATRGYQSVSFRTDSDIVERATELEMVKNITFQPFVEEIIRLKAAF PLFFIKWIPGKQNQKADLLAKEAIRLNEKN*" /label="ypdQ CDS" gene 1903565..1903963 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /label="ypdQ gene" promotor_-35 1903956..1903962 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1903977..1903988 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1903988 /Source="Nicolas_upshifts" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="upshifts" CDS 1904005..1904133 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054584.1" /db_xref="EnsemblGenomes-Gn:BSU22000" /db_xref="EnsemblGenomes-Tr:CAE01458" /db_xref="GOA:Q7WY66" /db_xref="InterPro:IPR017526" /db_xref="SubtiList:BG14176" /db_xref="UniProtKB/Swiss-Prot:Q7WY66" /translation="MKKKDKGRLTGGVTPQGDLEGNTHNDPKTELEERAKKSNTKR*" /label="sspL CDS" gene 1904005..1904133 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /label="sspL gene" S_feature 1904134..1905114 /Source="Nicolas_S_feature" /locus_tag="new_2310988_2311968" /HighExp="S8, S7, S5, S6, S4, C30, nit, ferm, Pyr, S3" /AntisenseName="exoA" /AntisenseCor="-0.365099613028674" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S832" CDS complement(1904141..1905031) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:16045613, 17038322, 17905985, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16045613, 17038322, 17905985, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5'3'-exonuclease" /protein_id="NP_390083.1" /db_xref="EnsemblGenomes-Gn:BSU22010" /db_xref="EnsemblGenomes-Tr:CAB14118" /db_xref="GOA:P54161" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="SubtiList:BG11606" /db_xref="UniProtKB/Swiss-Prot:P54161" /translation="MNNNKLLLVDGMALLFRAFFATAVHRNFMINDSGVPTNGVNGFL KHLITAVETFQPTHVVCCWDMGSKTYRNDLFQDYKANRSAPPVELIPQFDLAKEAAAE LGIMNIGFAGYEADDCIGTLADLFANEADITVVTGDRDLLQLLTDKVSVALLQKGIGN YKVYTKETFYEETGVMPKALIDIKALMGDSSDNYPGVKGIGEKTAYKLIREYETIDRL LENLSLLPKGQQGKIQQGLSDLEMSRKLAEIHCSVPLACTLKDALFTLQMEQAADMLR RHQIKGIERMLEKLNAREIV*" /label="exnP CDS" gene complement(1904141..1905031) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /label="exnP gene" downshifts complement(1904178) /Source="Nicolas_upshifts" /id="D1152" /incds=0 /nref=10 /ntot=174 /MaxReadThrough="2.94148" /MaxDrop="4.49836" /score="3.60870815" /energy="-15.6" /TU="U1726" /idTUdmin="U1726" /TUdmin="-284" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1905053..1905072) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1905060) /Source="Nicolas_upshifts" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1905084..1905090) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1905088 /Source="Nicolas_upshifts" /id="D1153" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="0.83304" /MaxDrop="4.41573" /score="0.126370352" /energy="-15" /TU="NA" /idTUdmin="U1725" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS complement(1905132..1905278) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097753.1" /db_xref="EnsemblGenomes-Gn:BSU22019" /db_xref="EnsemblGenomes-Tr:CAX52652" /db_xref="UniProtKB/Swiss-Prot:C0H443" /translation="MLGRTKLGNRNAQANNNAKKKNGFQTHFDSYAGREAEKLIASNK RHND*" /label="ypzF CDS" gene complement(1905132..1905278) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /label="ypzF gene" downshifts complement(1905148) /Source="Nicolas_upshifts" /id="D1154" /incds=0 /nref=253 /ntot=272 /MaxReadThrough="0.89691" /MaxDrop="8.47168" /score="25.632979" /energy="-12" /TU="NA" /idTUdmin="U1727" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1905302) /Source="Nicolas_upshifts" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1905303..1905314) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1905329..1905335) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1905353..1905610) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /experiment="publication(s) with functional evidences, PMID:20709900, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore associated protein" /protein_id="NP_390084.1" /db_xref="EnsemblGenomes-Gn:BSU22020" /db_xref="EnsemblGenomes-Tr:CAB14119" /db_xref="InterPro:IPR019688" /db_xref="SubtiList:BG11605" /db_xref="UniProtKB/Swiss-Prot:P54160" /translation="MSEVHKAISAHSSKQHEHIKAFMRLENMRELAIEEAVAKCRNDE PYTTDAINEITEQMNQLAKKGIVPTRRLVSKEMVREYVSRM*" /label="ypbS CDS" gene complement(1905353..1905610) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /label="ypbS gene" promotor_-10 complement(1905630..1905649) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1905645) /Source="Nicolas_upshifts" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1905661..1905668) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1905675..1909256) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /EC_number="3.6.5.5" /experiment="publication(s) with functional evidences, PMID:21205012, 23388828, 23249255, 26842743, 26530236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21205012, 23388828, 23249255, 26842743, 26530236; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dynamin GTPase" /protein_id="NP_390085.1" /db_xref="EnsemblGenomes-Gn:BSU22030" /db_xref="EnsemblGenomes-Tr:CAB14120" /db_xref="GOA:P54159" /db_xref="InterPro:IPR022812" /db_xref="InterPro:IPR027094" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11604" /db_xref="UniProtKB/Swiss-Prot:P54159" /translation="MTDQNRKELLHKTGELYKQFIENQDEQRAAKLAAVMKKAADEEV YIAFTGHYSAGKSSLLNCLLMENILPTSPIPTSANLVVIRNGEKRVRLHTTDGACAEL EGTYQKDKVQQYCKDGEQIESVEIFDRYTEIDSGVAYIDTPGIDSTDDAHFLSAASIL HQADALFYVVHYNHVHAEENVKFLRSIKESIPNVYFIVNQIDRHDETETKFGDYQAQV EEMLCNEGISREALYFTSVTEPDHPFNQMGALREELSRIEQQSKSNMQALTEQKVRNL LKEHTEMLKKDETGAPSFAEQLNIHTGLVQSLRDQLDEAEKQMTEAEKRMQEEINRIL KNANLTPFEMRELAAAFLESQEPSFKTGFFFSKAKTAQERDKRRNAFFSDVAKRTEAE ADWHMIDTLHKLAKVFDVYTAESEKLIQAYRTPLDISIIEHAVKHGAAFSSEYVLQYT KDLAELIRKEAKREAADIIKVLSAMVKERVSKDVQTINDRLVQESEKLVFLQEQARLE NNAREKTDRLWAIWEEESACPMHIDTEWFKSKKTRVAAPEQKQGRSQLTAQPMPKSEI KMEQEMPLQDQIKRFYTLSDILGECSMLLKQTSAFRERVKRLEERKFTLALFGGFSSG KSSFANALVGERVLPSSPTPTTATINKITKPINGNLNKTANVVFKTEDDLTAEILQLT GIPKEPAGRSFTEKWEKAVKKNRLQEEHVKLISNFLLAYEKYQQYIQEQKKLTIPLSE LKPYVAEETTACAVKEVTVYYTCPLTEKGITIVDTPGASSMNKRHTELAFQYIKDADA FFYMTYYQHSFSKGDRSFLRKLGLVKESLSMDKMFFIINAADLAKDKTELETVTDYVS AELVKEGVYEPQLFTVSSKEELVGKPESFYNQFSKVRKHLDRFIEVDVKKASAAQLSS EADKLCETVFQLHQSQHQSREEKEAQKQCLMLSFERTAADIEKRRNSKTIIEKVKKDT REQLYHIAQRLSYFANDLLKSAFHPGLQNGDWKKNVSKAMTTALHEYLFEYIQEIKTL DVRMSGFIERHINEEWLDHFQKTLNEDGYFSVYAGDQHSNGIQLKEVEPEIEERAFEQ ELKEIKSPKQFFEQKGKATFIEAVRMKLTKITEAWIKNEEESLISHYTAHLRRLQEDM GEKAIAQITDQKETYLRGYAEGEHAKEIEMAYQACISWKNSDNTIKM*" /label="dynA CDS" gene complement(1905675..1909256) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /label="dynA gene" S_feature complement(1909257..1909328) /Source="Nicolas_S_feature" /locus_tag="new_2316111_2316182_c" /HighExp="LBGstat, T1.30H, T1.0H, BMM, T2.30H, M9-stat, MG 150, T0.30H, T2.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S833" misc_feature complement(1909318..1909337) /Source="Nicolas_upshift_promotors" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1909328) /Source="Nicolas_upshifts" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="upshifts" S_feature complement(1909373..1909570) /Source="Nicolas_S_feature" /locus_tag="new_2316227_2316424_c" /HighExp="HiOs, B60, GM 25, S7, GM 15, B36, S5, S8, GM 5, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.24118200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S834" downshifts complement(1909416) /Source="Nicolas_upshifts" /id="D1155" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.11615" /MaxDrop="3.46525" /score="27.1937922" /energy="-9.7" /TU="U1730" /idTUdmin="U1730" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1909432..1909521) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513974.1" /db_xref="EnsemblGenomes-Gn:BSU22036" /db_xref="EnsemblGenomes-Tr:CCQ48599" /db_xref="UniProtKB/TrEMBL:L8ECR0" /translation="MTMLFLLGAVCTYSVLIGFVLKGISNKSV*" /label="fbpC CDS" gene complement(1909432..1909521) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /label="fbpC gene" promotor_-10 complement(1909549..1909568) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1909570) /Source="Nicolas_upshifts" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1909583..1909590) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1909592..1910098) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /EC_number="2.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 7726551, 8396117, 19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 7726551, 8396117, 19465653; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alkylpyrone methyltransferase (polyketide synthesis)" /protein_id="NP_390086.1" /db_xref="EnsemblGenomes-Gn:BSU22040" /db_xref="EnsemblGenomes-Tr:CAB14121" /db_xref="GOA:P54158" /db_xref="InterPro:IPR007269" /db_xref="SubtiList:BG11603" /db_xref="UniProtKB/Swiss-Prot:P54158" /translation="MFWLLIAILIVQRAAEMAVARQNEQKVKKQGAIEFGESHYPYII TMHILFFLSLIAEVLLMNKQPSSWWLGIAAVILSVQIVRYWALCSLGAYWNTKILVVP GVELVKKGPYKWMKHPNYAVVILEILLIPLLYQAYVTMCLFSIFNAVLLSVRIRAEDK ALQEYSVK*" /label="bpsB CDS" gene complement(1909592..1910098) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /label="bpsB gene" CDS complement(1910102..1911199) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /EC_number="2.3.1.-" /function="15.10: Adaptations to atypical conditions" /experiment="publication(s) with functional evidences, PMID:19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19465653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous alkylpyrone synthase BpsA (polyketide synthesis)" /protein_id="NP_390087.1" /db_xref="EnsemblGenomes-Gn:BSU22050" /db_xref="EnsemblGenomes-Tr:CAB14122" /db_xref="GOA:P54157" /db_xref="InterPro:IPR001099" /db_xref="InterPro:IPR011141" /db_xref="InterPro:IPR012328" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018088" /db_xref="SubtiList:BG11523" /db_xref="UniProtKB/Swiss-Prot:P54157" /translation="MAFILSIGTSLPAYNVNQEKAAEFARYMFQHSFKDIDRLLSSFK NGQIHSRQFVKPIEWYKEGHSFEEKNQIYIEETLKHSRAAVRECLSHPEFFQEAIPYE KVEAVFFVSSTGLSTPSIEARLMNELPFSPYTKRIPIWGLGCAGGASGLARAAEYCKA YPEAFVLVISAELCSLTFQPEDKTKSNLIGTSLFGDGIAAALLCGEKADRRVSKLKLA PKIMDAQSVLMKQSEDVMGWDFTDQGFKVIFSRDIPTLVEKWLKTNVQIFLDKHKLSF HDISVFLAHPGGKKVIDAYIKSLGLSSEKLSSAQSILQKHGNMSSATILYVIKDHLQN GHKKEAERGLIGALGPGFSSELLLFSWEKGA*" /label="bpsA CDS" gene complement(1910102..1911199) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /label="bpsA gene" promotor_-10 complement(1911217..1911228) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1911220) /Source="Nicolas_upshifts" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1911243..1911249) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1911273..1912589) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098051, 12923093, 15549109, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098051, 12923093, 15549109, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xanthine permease" /protein_id="NP_390088.1" /db_xref="EnsemblGenomes-Gn:BSU22060" /db_xref="EnsemblGenomes-Tr:CAB14123" /db_xref="GOA:P42086" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG11080" /db_xref="UniProtKB/Swiss-Prot:P42086" /translation="MRNGFGKTLSLGIQHVLAMYAGAIVVPLIVGKAMGLTVEQLTYL VSIDIFMCGVATLLQVWSNRFFGIGLPVVLGCTFTAVSPMIAIGSEYGVSTVYGSIIA SGILVILISFFFGKLVSFFPPVVTGSVVTIIGITLMPVAMNNMAGGEGSADFGDLSNL ALAFTVLSIIVLLYRFTKGFIKSVSILIGILIGTFIAYFMGKVQFDNVSDAAVVQMIQ PFYFGAPSFHAAPIITMSIVAIVSLVESTGVYFALGDLTNRRLTEIDLSKGYRAEGLA VLLGGIFNAFPYTAFSQNVGLVQLTGIKKNAVIVVTGVILMAFGLFPKIAAFTTIIPS AVLGGAMVAMFGMVIAYGIKMLSRIDFAKQENLLIVACSVGLGLGVTVVPDIFKQLPS ALTLLTTNGIVAGSFTAVVLNIVYNVFSKAKKIEQEADLAEQKTAV*" /label="pbuX CDS" gene complement(1911273..1912589) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /label="pbuX gene" downshifts complement(1911286) /Source="Nicolas_upshifts" /id="D1156" /incds=0 /nref=177 /ntot=215 /MaxReadThrough="1.81377" /MaxDrop="6.3089" /score="32.8866099" /energy="-9" /TU="U1733" /idTUdmin="U1732" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1912586..1913170) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /EC_number="2.4.2.22" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12923093, 15549109, 19381559, 20108980, 20200045" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923093, 15549109, 19381559, 20108980, 20200045; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine phosphoribosyltransferase" /protein_id="NP_390089.1" /db_xref="EnsemblGenomes-Gn:BSU22070" /db_xref="EnsemblGenomes-Tr:CAB14124" /db_xref="GOA:P42085" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010079" /db_xref="InterPro:IPR029057" /db_xref="PDB:1Y0B" /db_xref="PDB:2FXV" /db_xref="SubtiList:BG11079" /db_xref="UniProtKB/Swiss-Prot:P42085" /translation="MEALKRKIEEEGVVLSDQVLKVDSFLNHQIDPLLMQRIGDEFAS RFAKDGITKIVTIESSGIAPAVMTGLKLGVPVVFARKHKSLTLTDNLLTASVYSFTKQ TESQIAVSGTHLSDQDHVLIIDDFLANGQAAHGLVSIVKQAGASIAGIGIVIEKSFQP GRDELVKLGYRVESLARIQSLEEGKVSFVQEVHS*" /label="xpt CDS" gene complement(1912586..1913170) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /label="xpt gene" misc_RNA complement(1913259..1913359) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" /label="gswA RNA" gene complement(1913259..1913359) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /label="gswA gene" downshifts complement(1913266) /Source="Nicolas_upshifts" /id="D1157" /incds=0 /nref=8 /ntot=35 /MaxReadThrough="6.97435" /MaxDrop="3.25" /score="36.5247418" /energy="-19.2" /TU="U1732,U1733" /idTUdmin="U1734" /TUdmin=1870 /isTUend="FALSE" /label="downshifts" S_feature complement(1913360..1913500) /Source="Nicolas_S_feature" /locus_tag="new_2320214_2320354_c" /HighExp="dia15, BT, dia5, Diami, C90, LBGtran, Lbtran, Gly, SMMPr, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.291, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S835" CDS complement(1913501..1915006) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /EC_number="3.4.17.19" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7765282, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="metal-dependent carboxypeptidase" /protein_id="NP_390090.1" /db_xref="EnsemblGenomes-Gn:BSU22080" /db_xref="EnsemblGenomes-Tr:CAB14125" /db_xref="GOA:P50848" /db_xref="InterPro:IPR001333" /db_xref="PDB:3HQ2" /db_xref="SubtiList:BG11458" /db_xref="UniProtKB/Swiss-Prot:P50848" /translation="MEIHTYEKEFFDLLKRISHYSEAVALMHWDSRTGAPKNGSEDRA ESIGQLSTDIFNIQTSDRMKELIDVLYERFDDLSEDTKKAVELAKKEYEENKKIPEAE YKEYVILCSKAETAWEEAKGKSDFSLFSPYLEQLIEFNKRFITYWGYQEHPYDALLDL FEPGVTVKVLDQLFAELKEAIIPLVKQVTASGNKPDTSFITKAFPKEKQKELSLYFLQ ELGYDFDGGRLDETVHPFATTLNRGDVRVTTRYDEKDFRTAIFGTIHECGHAIYEQNI DEALSGTNLSDGASMGIHESQSLFYENFIGRNKHFWTPYYKKIQEASPVQFKDISLDD FVRAINESKPSFIRVEADELTYPLHIIIRYEIEKAIFSNEVSVEDLPSLWNQKYQDYL GITPQTDAEGILQDVHWAGGDFGYFPSYALGYMYAAQLKQKMLEDLPEFDALLERGEF HPIKQWLTEKVHIHGKRKKPLDIIKDATGEELNVRYLIDYLSNKYSNLYLL*" /label="ypwA CDS" gene complement(1913501..1915006) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /label="ypwA gene" promotor_no_box complement(1914942..1915042) /Source="Nicolas_upshift_promotors" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1914982) /Source="Nicolas_upshifts" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="upshifts" downshifts 1914994 /Source="Nicolas_upshifts" /id="D1158" /incds=0 /nref=4 /ntot=78 /MaxReadThrough="1.34397" /MaxDrop="3.87399" /score="12.6922524" /energy="-13.3" /TU="NA" /idTUdmin="U1735" /TUdmin="-5588" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1915032..1915051) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1915048) /Source="Nicolas_upshifts" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1915065..1915072) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1915118..1916110) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 9846747; Product type t: transporter" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate permease" /protein_id="NP_390091.1" /db_xref="EnsemblGenomes-Gn:BSU22090" /db_xref="EnsemblGenomes-Tr:CAB14126" /db_xref="GOA:P50847" /db_xref="InterPro:IPR004684" /db_xref="InterPro:IPR018395" /db_xref="SubtiList:BG11399" /db_xref="UniProtKB/Swiss-Prot:P50847" /translation="MKIKATIERVPGGMMIIPLFLGAALNTFAPGTAEFFGGFTGALI TGTLPILGVFIFCVGATIDFRSSGYIARKGITLLLGKIGFAALLGVIAAQFIPDDGIQ SGFFAGLSVLAIVAVMNETNGGLYLALMNHMGRKEDAGAFAFISTESGPFMTMVTFGV TGLAAFPWETLAATVIPFLLGCILGNLDHDLRDLFSKVVPAIIPFFAFSLGNTLNFGM LIQSGLLGIFIGVSVVILSGSSLFLLDRFIARGDGVAGVAASSTAGAAVAVPYALAEA NASFAPVAESATAIIATSVIVTSLLTPLATVWVDKKIKQKKRRTPPPKNQMTIN*" /label="kdgT CDS" gene complement(1915118..1916110) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /label="kdgT gene" downshifts complement(1915136) /Source="Nicolas_upshifts" /id="D1159" /incds=0 /nref=15 /ntot=59 /MaxReadThrough="3.32882" /MaxDrop="5.85236" /score="36.5247418" /energy="-19.2" /TU="NA" /idTUdmin="U1734" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1916155..1916745) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /EC_number="4.1.2.14" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate-6-phosphate aldolase" /protein_id="NP_390092.1" /db_xref="EnsemblGenomes-Gn:BSU22100" /db_xref="EnsemblGenomes-Tr:CAB14127" /db_xref="GOA:P50846" /db_xref="InterPro:IPR000887" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031338" /db_xref="SubtiList:BG11396" /db_xref="UniProtKB/Swiss-Prot:P50846" /translation="MESKVVENRLKEAKLIAVIRSKDKQEACQQIESLLDKGIRAVEV TYTTPGASDIIESFRNREDILIGAGTVISAQQAGEAAKAGAQFIVSPGFSADLAEHLS FVKTHYIPGVLTPSEIMEALTFGFTTLKLFPSGVFGIPFMKNLAGPFPQVTFIPTGGI HPSEVPDWLRAGAGAVGVGSQLGSCSKEDLQAVFQV*" /label="kdgA CDS" gene complement(1916155..1916745) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /label="kdgA gene" CDS complement(1916747..1917721) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /EC_number="2.7.1.45" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143, 15039578; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate kinase" /protein_id="NP_390093.1" /db_xref="EnsemblGenomes-Gn:BSU22110" /db_xref="EnsemblGenomes-Tr:CAB14128" /db_xref="GOA:P50845" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG11397" /db_xref="UniProtKB/Swiss-Prot:P50845" /translation="MKLDAVTFGESMAMFYANEYGGLHEVSTFSKGLAGAESNVACGL ARLGFRMGWMSKVGNDQLGTFILQELKKEGVDVSRVIRSQDENPTGLLLKSKVKEGDP QVTYYRKNSAASTLTTAEYPRDYFQCAGHLHVTGIPPALSAEMKDFTYHVMNDMRNAG KTISFDPNVRPSLWPDQATMVHTINDLAGLADWFFPGIAEGELLTGEKTPEGIADYYL KKGASFVAIKLGKEGAYFKTGTSEGFLEGCRVDRVVDTVGAGDGFAVGVISGILDGLS YKDAVQRGNAIGALQVQAPGDMDGLPTREKLASFLSAQRTVHQKKGDY*" /label="kdgK CDS" gene complement(1916747..1917721) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /label="kdgK gene" CDS complement(1917759..1918778) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9846747, 15223311, 17322190, 28040177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9846747, 15223311, 17322190, 28040177; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the Kdg operon (KdgR-galacturonate)" /protein_id="NP_390094.1" /db_xref="EnsemblGenomes-Gn:BSU22120" /db_xref="EnsemblGenomes-Tr:CAB14129" /db_xref="GOA:P50844" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG11398" /db_xref="UniProtKB/Swiss-Prot:P50844" /translation="MKKKTTGHTTIKDVAECAGVSKSTVSRYINGKIDAISPEKVKNI KKAIAELNYRPSKMAQGLKIKKSKLIGFVVADITNPFSVAAFRGVEEVCDQYGYSIMV CNTDNSPEKEREMLLKLEAHSVEGLILNATGENKDVLRAFAEQQIPTILIDRKLPDLK LDTVTTDNRWITKEILQKVYSKGYTDVALFTEPISSISPRAERAAVYQEMASVQNVNG LVRLHEIDVKDKEQLKAELRSFHKEMPEQKKAILALNGLIMLKIISCMEELGLRIPQD IGIAGFDDTEWYKLIGPGITTIAQPSHDMGRTAMERVLKRIEGDKGAPQTIELEAKVI MRKSL*" /label="kdgR CDS" gene complement(1917759..1918778) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /label="kdgR gene" promotor_-10 complement(1918826..1918845) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1918836) /Source="Nicolas_upshifts" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1918857..1918864) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1918899..1918906 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1918920..1918999 /Source="Nicolas_S_feature" /locus_tag="new_2325774_2325853" /HighExp="HiTm, Heat, nit, LBGstat, ferm, T-0.40H, HiOs, T1.30H, MG 150, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S836" upshifts 1918920 /Source="Nicolas_upshifts" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1918921..1918940 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1919000..1919827 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /EC_number="5.3.1.17" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 23437267, 27227414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase" /protein_id="NP_390095.1" /db_xref="EnsemblGenomes-Gn:BSU22130" /db_xref="EnsemblGenomes-Tr:CAB14130" /db_xref="GOA:P50843" /db_xref="InterPro:IPR007045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR027449" /db_xref="SubtiList:BG11401" /db_xref="UniProtKB/Swiss-Prot:P50843" /translation="MENRYSVHPEQVKRFTTEELRSHFLMDSLFTENKLTMYYSHEDR VVIGGAAPGQSELKLDAGDFLKTDFFLERREIGIINVGQPGAVRVGDDEYVLQTKDFL YIGMGNQDVSFSSLNGEKAKFYFVSACAHKSYPTQKAALSELTPDRLGDDAASNVRSL YKVIHQDGIKSCQLMMGITMLDQNNNWNTMPAHVHDRRMEAYLYLDLEKDSKVFHFMG QPDETRHLVVGNEQAVLSPAWSIHSGAGTSNYSFVWAMAGENYTFTDMDLIPMDGLK* " /label="kduI CDS" gene 1919000..1919827 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /label="kduI gene" CDS 1919829..1920593 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /EC_number="1.1.1.127" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 24509771, 27028675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate oxidoreductase" /protein_id="NP_390096.1" /db_xref="EnsemblGenomes-Gn:BSU22140" /db_xref="EnsemblGenomes-Tr:CAB14131" /db_xref="GOA:P50842" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011286" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11400" /db_xref="UniProtKB/Swiss-Prot:P50842" /translation="MGYLHDAFSLKGKTALVTGPGTGIGQGIAKALAGAGADIIGTSH TSSLSETQQLVEQEGRIFTSFTLDMSKPEAIKDSAAELFENRQIDILVNNAGIIHREK AEDFPEENWQHVLNVNLNSLFILTQLAGRHMLKRGHGKIINIASLLSFQGGILVPAYT ASKHAVAGLTKSFANEWAASGIQVNAIAPGYISTANTKPIRDDEKRNEDILKRIPAGR WGQADDIGGTAVFLASRASDYVNGHILAVDGGWLSR*" /label="kduD CDS" gene 1919829..1920593 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /label="kduD gene" downshifts 1920582 /Source="Nicolas_upshifts" /id="D1160" /incds=0 /nref=12 /ntot=160 /MaxReadThrough="0.66029" /MaxDrop="3.56178" /score="23.0070487" /energy="-12.3" /TU="NA" /idTUdmin="U1735" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1920624) /Source="Nicolas_upshifts" /id="D1161" /incds=0 /nref=28 /ntot=225 /MaxReadThrough="1.88107" /MaxDrop="5.27501" /score="35.5168663" /energy="-12.3" /TU="NA" /idTUdmin="U1736" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(1920634..1922559) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /EC_number="3.6.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8385320, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent helicase" /protein_id="NP_390097.1" /db_xref="EnsemblGenomes-Gn:BSU22150" /db_xref="EnsemblGenomes-Tr:CAB14132" /db_xref="GOA:P50831" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11457" /db_xref="UniProtKB/Swiss-Prot:P50831" /translation="MTTSRLPFSLTKTKNFYEELNNWIGDVFYDILPEKGFDLRDEQV FMAFQLERAFKEKKVMFAEAGVGTGKTLVYLLFAISYARYVGKPAIIACADETLIEQL VKKEGDISKLAEHLDLKIDTRLSKSHEQYLCLKKLEKTMQRSDDDKWLDLYESLPSFV HESQAMQRFYPYGDRKQYANLSNEEWSDVSYDSFQDCLTCDMRHRCGLTLSRDYYRKS TDLIICSHDFYMEHVWTEESRKREGQLPLLPDHSAVVFDEGHLLEFAAQKALTYRVKQ STLELFLERLLQNDIREEFAELIEDALLANDEFFYVLSEESKEVAGSHRLEIKNDHRV KKAADELCRLLDKIGEALVFESEMYTIDQYELSVVEEYVEQMAYSLSLYQKDAISWLE KKEAESTFVVMPRTVAEVLGEKVFSKKIPYIFSSATLSEGGSFDYIADSLGIHDYLSL TVDSPYDYDEQMSINLYAKTDMDAEQKTAETIETIKRYKGRTLVLFPSFEELNEFKEL SAAWELPYPIFFEGDEEISSLVEKFQEEEETVLCSVHLWEGLDIPGDALKNVTIWSLP FPPHDPVFTAKRNGAKKDPFEEVDLPYMLLRVRQGIGRLIRSNQDSGSIHIYAGGENE RIIDEVKKVLPVEPHMM*" /label="ypvA CDS" gene complement(1920634..1922559) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /label="ypvA gene" promotor_-10 complement(1922590..1922609) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1922594) /Source="Nicolas_upshifts" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1922596..1922660) /Source="Nicolas_S_feature" /locus_tag="new_2329450_2329514_c" /HighExp="S3, S4, S8, S7, LoTm, S5, S6, BT, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S837" promotor_-35 complement(1922624..1922628) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1922661..1922852) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390098.1" /db_xref="EnsemblGenomes-Gn:BSU22160" /db_xref="EnsemblGenomes-Tr:CAB14133" /db_xref="SubtiList:BG11456" /db_xref="UniProtKB/Swiss-Prot:P50841" /translation="MLNSEHFNLIQRALDATANELKELGTDSSPSVISHAQTDLEKAV EHIYSTDHPFLSSHVINRK*" /label="yptA CDS" gene complement(1922661..1922852) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /label="yptA gene" promotor_-10 complement(1922871..1922889) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1922880) /Source="Nicolas_upshifts" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1922882..1923187) /Source="Nicolas_S_feature" /locus_tag="new_2329736_2330041_c" /HighExp="Cold, G135, G180, C30, G150, Oxctl, Paraq, H2O2, LBGstat, LPh" /AntisenseName="ypzG" /AntisenseCor="-0.39420155633160697" /AntisenseRegPval="-10.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S838" promotor_-35 complement(1922905..1922910) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1922919..1922925 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1922940..1922951 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1922949 /Source="Nicolas_upshifts" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="upshifts" CDS 1923016..1923168 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097754.1" /db_xref="EnsemblGenomes-Gn:BSU22169" /db_xref="EnsemblGenomes-Tr:CAX52653" /db_xref="InterPro:IPR025413" /db_xref="UniProtKB/Swiss-Prot:C0H444" /translation="MSYRNRLDQHSELFHHNWTRPKRSKSQVNGHTEMSQTNIILRSN AKAHRW*" /label="ypzG CDS" gene 1923016..1923168 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /label="ypzG gene" downshifts 1923178 /Source="Nicolas_upshifts" /id="D1162" /incds=0 /nref=35 /ntot=65 /MaxReadThrough="1.2837" /MaxDrop="7.64655" /score="-9.36260071" /energy="-16.3" /TU="NA" /idTUdmin="U1738" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1923221..1924378) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /EC_number="2.1.1.264" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22210896, 22362734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="m(7)G2069 methylase of 23S rRNA" /protein_id="NP_390099.1" /db_xref="EnsemblGenomes-Gn:BSU22170" /db_xref="EnsemblGenomes-Tr:CAB14134" /db_xref="GOA:P50840" /db_xref="InterPro:IPR000241" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11455" /db_xref="UniProtKB/Swiss-Prot:P50840" /translation="MKKYTLIATAPMGIEAVVAKEVRDLGYECKVDNGKVIFEGDALA ICRANLWLRTADRIKVQVASFKAKTFDELFEKTKAINWRSFIPENGKFPVIGKSVKST LASVPDCQRIVKKAIVEKLKLQSGKANDWIEETGAEYKVEISLLKDQALITLDSSGTG LHKRGYRVDQGGAPIKETLAAALVQLTNWTPDRPFVDPFCGSGTIAIEAALIGQNIAP GFNRDFVSEDWEWIGKDLWNKARLEVEEKANYDQPLTIFASDIDHRMVQIAKENAEEA GLGDLIQFKQMQVKDFTTNLEFGVIVGNPPYGERLGEKKAVEQMYKEMGQAFEPLDTW SVYMLTSNENFEEAYGRKATKKRKLFNGFIKTDYYQYWSKVRPQRKKTENA*" /label="rlmKB CDS" gene complement(1923221..1924378) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /label="rlmKB gene" downshifts complement(1923232) /Source="Nicolas_upshifts" /id="D1163" /incds=0 /nref=86 /ntot=240 /MaxReadThrough="4.31441" /MaxDrop="4.58268" /score="14.6684819" /energy="-6.2" /TU="U1739" /idTUdmin="U1740" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(1924466..1924866) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /product="RNA component of ribonuclease P (RNase P) (catalytic subunit, ribozyme)" /experiment="publication(s) with functional evidences, PMID:1699929, 16980484, 17919279, 22448220" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1699929, 16980484, 17919279, 22448220; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rnpB RNA" gene complement(1924466..1924866) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /label="rnpB gene" downshifts complement(1924476) /Source="Nicolas_upshifts" /id="D1164" /incds=0 /nref=200 /ntot=276 /MaxReadThrough="6.17541" /MaxDrop="7.4677" /score="0.20729905" /energy="-10.4" /TU="U1739,U1740" /idTUdmin="U1742" /TUdmin=406 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1924863..1924882) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1924881) /Source="Nicolas_upshifts" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1924897..1924903) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1924925..1925221) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:18363795, 18776011, 19429628, 25845974, 27257764" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18363795, 18776011, 19429628, 25845974, 27257764; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell division protein" /protein_id="NP_390100.1" /db_xref="EnsemblGenomes-Gn:BSU22180" /db_xref="EnsemblGenomes-Tr:CAB14135" /db_xref="GOA:P0CI74" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR011229" /db_xref="InterPro:IPR019933" /db_xref="PDB:4UG3" /db_xref="PDB:5AN5" /db_xref="SubtiList:BG11454" /db_xref="UniProtKB/Swiss-Prot:P0CI74" /translation="MLADKVKLSAKEILEKEFKTGVRGYKQEDVDKFLDMIIKDYETF HQEIEELQQENLQLKKQLEEASKKQPVQSNTTNFDILKRLSNLEKHVFGSKLYD*" /label="gpsB CDS" gene complement(1924925..1925221) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /label="gpsB gene" promotor_-10 complement(1925246..1925265) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1925256) /Source="Nicolas_upshifts" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1925279..1925286) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1925299..1925928) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390101.2" /db_xref="EnsemblGenomes-Gn:BSU22190" /db_xref="EnsemblGenomes-Tr:CAB14136" /db_xref="InterPro:IPR010697" /db_xref="PDB:2NX2" /db_xref="SubtiList:BG11453" /db_xref="UniProtKB/Swiss-Prot:P50838" /translation="MENVQLDGVNNAAQQMGPTGAPFFKAGEMMKVLAITGYKPFELG IFKQDDKALYYIKKAIKNRLIAFLDEGLEWILISGQLGVELWAAEAAYDLQEEYPDLK VAVITPFYEQEKNWKEPNKEQYEAVLAQADYEASLTHRPYESPLQFKQKNQFFIDKSD GLLLLYDPEKEGSPKYMLGTAEKRREQDGYPIYFITMDDLRVTVEEDSY*" /label="ypsA CDS" gene complement(1925299..1925928) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /label="ypsA gene" downshifts complement(1925894) /Source="Nicolas_upshifts" /id="D1165" /incds=0 /nref=37 /ntot=160 /MaxReadThrough="5.74028" /MaxDrop="8.12374" /score="7.18626302" /energy="-9.8" /TU="U1741,U1742" /idTUdmin="U1744" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1925930..1926157) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2821284, 10075739, 10400595, 1518043, 1691789, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2821284, 10075739, 10400595, 1518043, 1691789, 19933362; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner)" /protein_id="NP_390102.1" /db_xref="EnsemblGenomes-Gn:BSU22200" /db_xref="EnsemblGenomes-Tr:CAB14137" /db_xref="GOA:P07791" /db_xref="InterPro:IPR020108" /db_xref="SubtiList:BG10493" /db_xref="UniProtKB/Swiss-Prot:P07791" /translation="MHHCRPHMMAPIVHPTHCCEHHTFSKTIVPHIHPQHTTNVNHQH FQHVHYFPHTFSNVDPATHQHFQAGKPCCDY*" /label="cotD CDS" gene complement(1925930..1926157) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /label="cotD gene" promotor_-10 complement(1926185..1926204) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-10" upshifts complement(1926200) /Source="Nicolas_upshifts" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="upshifts" S_feature complement(1926202..1926356) /Source="Nicolas_S_feature" /locus_tag="new_2333056_2333210_c" /HighExp="LBGexp, dia15, Paraq, H2O2, Heat, G135, UNK1, Lbexp, BMM, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.808141" /TUshortSig="SigA, Sig-, SigA, SigA" /TUshortPSig="1, 0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S839" promotor_-35 complement(1926218..1926226) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-35" CDS complement(1926241..1926369) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513975.1" /translation="MTLVIFKGRVGMYKGVFYLFFVVVFLIAFVFSNFKDSLIAHF*" /label="conserved protein of unknown function CDS" gene complement(1926241..1926369) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /label="gene" upshifts complement(1926356) /Source="Nicolas_upshifts" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" S_feature complement(1926358..1926469) /Source="Nicolas_S_feature" /locus_tag="new_2333212_2333323_c" /HighExp="Sw, M40t90, Etha, Salt, M40t45, H2O2, S8, S6, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S840" promotor_-10 complement(1926359..1926378) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" promotor_-35 complement(1926394..1926398) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1926470..1927711) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23249255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding enzyme" /protein_id="NP_390103.1" /db_xref="EnsemblGenomes-Gn:BSU22210" /db_xref="EnsemblGenomes-Tr:CAB14138" /db_xref="GOA:P50837" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11452" /db_xref="UniProtKB/Swiss-Prot:P50837" /translation="MSLKGKLQRMKKHMALDEGEQKIEAGKQENHFDDIPFLEEWEAF GMKPFIFEDEYCLIREVEYPLSHRHGLYSFSELEEVITLWNQSGLSHTLSAKGYNKNN LFFFDTETTGLGGGAGNTIFLLGHARVYEDRVTVKQHLLPKPGNEVALYQSFLSEVDI TSLVTYNGKAFDWPQVKTRHTLIRDRLPKLPEFGHFDLLHGARRLWKHKMDRVSLGTV EKEELGIRRLEDTPGYLAPMLYFHFIKAQEPDLLKGVLHHNEMDVLSLISLYIHMSKK ILSESHAPKEHSEAYAMAKWFMAHKETDQAIKQLERLIEKSFEDQDSARLDLSLLYKK QNRLEEAVPLWEKLSRSQNQKCRYAAVIELAKYFEHKKKEFGKALQVAEQSLSDAACL SEKETEKLHVRIARLKRKYSS*" /label="yprB CDS" gene complement(1926470..1927711) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /label="yprB gene" promotor_-10 complement(1927425..1927443) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-10" upshifts complement(1927434) /Source="Nicolas_upshifts" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="upshifts" promotor_-35 complement(1927458..1927465) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-35" CDS complement(1927727..1929976) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /EC_number="3.6.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_390104.1" /db_xref="EnsemblGenomes-Gn:BSU22220" /db_xref="EnsemblGenomes-Tr:CAB14139" /db_xref="GOA:P50830" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018973" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11451" /db_xref="UniProtKB/Swiss-Prot:P50830" /translation="MKKKSLTELISDLKGNENVVNWHEIEPREAKTRPMPESIDERIK AALSKRGIDELYTHQYSAFQYVQKGESIVTVTPTASGKTLCYNLPVLQSIAQDETNRA LYLFPTKALAQDQKSELNEIIDEMGIDIKSFTYDGDTSPAIRQKVRKAGHIVITNPDM LHSAILPHHTKWVSLFENLKYIVIDELHTYRGVFGSHVANVIRRLKRICRFYGSDPVF ICTSATIANPKELGEQLTGKPMRLVDDNGAPSGRKHFVFYNPPIVNKPLNIRRSATAE VNELAKEFLKNKVQTIVFARSRVRVEIILSHIQELVKKEIGTKSIRGYRGGYLPKERR EIERGLREGDILGVVSTNALELGVDIGQLQVCVMTGYPGSVASAWQQAGRAGRRHGES LIIMVANSTPIDQYIVRHPEYFFNRSPESARINPENLIILVDHLKCAAYELPFRADEE FGAMEVSDILEYLQEEAVLHRNGERYHWASESFPASNISLRSASQENVVIVDQSDIAN VRIIGEMDRFSAMTLLHDEAIYLHEGVQYQVEKLDWDHKKAYVRKVDVEYYTDANLAV QLKVLEIDKTKEKSRTSLHYGDVTVNALPTIFKKIKMTTFENIGSGPIHLPEEELHTS AAWLEIKTADEDIGEKTLEQLLLGISNVLQHIVPVYIMCDRNDVHVVSQIKAAHTGLP TIFLYDHYPGGIGLAEEVFKRFSDINEAAKQLITHCPCHDGCPSCIGTEIEGIKAKER ILQLLDQMS*" /label="yprA CDS" gene complement(1927727..1929976) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /label="yprA gene" promotor_-10 complement(1929992..1930011) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1930008) /Source="Nicolas_upshifts" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1930025..1930031) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1930079..1930585) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10627040, 28731580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase system enzyme IIA component" /protein_id="NP_390105.1" /db_xref="EnsemblGenomes-Gn:BSU22230" /db_xref="EnsemblGenomes-Tr:CAB14140" /db_xref="GOA:P50829" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG11450" /db_xref="UniProtKB/Swiss-Prot:P50829" /translation="MLKKLFGMGKIQEKVTEEVIYSPADGTVMDLSDVPDPVFSQKMM GEGIAVEPSSGEIVSPAEGEVIQIFHTKHAVGIRTRSGIELLIHVGLETVNMNGEGFT AHIKEGDKVKVGDPLITCDLELIKEKASSTVIPIVIMNGEAVGSMVSAGEKAARKGES KLFTIKAK*" /label="ypqE CDS" gene complement(1930079..1930585) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /label="ypqE gene" downshifts complement(1930102) /Source="Nicolas_upshifts" /id="D1166" /incds=0 /nref=88 /ntot=236 /MaxReadThrough="4.55156" /MaxDrop="6.1724" /score="32.5355561" /energy="-10.2" /TU="U1745" /idTUdmin="U1747" /TUdmin=808 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1930629..1930648) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1930646) /Source="Nicolas_upshifts" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1930662..1930669) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" promotor_-35 1930667..1930676 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1930690..1930709 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1930702 /Source="Nicolas_upshifts" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="upshifts" CDS 1930723..1931142 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_390106.1" /db_xref="EnsemblGenomes-Gn:BSU22240" /db_xref="EnsemblGenomes-Tr:CAB14141" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11449" /db_xref="UniProtKB/Swiss-Prot:P50836" /translation="MEFHDDKKNELQKKEEIITEAIDTLFQSSAFGNLINGFQNLINS SLKDVQTTIHVRERDTGLYIDITIPATFRDGEIVVDVKSRYLHVTLQEKQKHQNEATF TSMTRTVQLPYEVRQEDMETSWNEQTMTLFFPKNKHE*" /label="ypqA CDS" gene 1930723..1931142 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /label="ypqA gene" S_feature 1931143..1931293 /Source="Nicolas_S_feature" /locus_tag="new_2337997_2338147" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, nit" /AntisenseName="yppG" /AntisenseCor="0.95679380325708796" /AntisenseRegPval="-144.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S841" CDS complement(1931163..1931540) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein; methionine-glutamine-rich protein" /protein_id="NP_390107.1" /db_xref="EnsemblGenomes-Gn:BSU22250" /db_xref="EnsemblGenomes-Tr:CAB14142" /db_xref="InterPro:IPR025555" /db_xref="SubtiList:BG11448" /db_xref="UniProtKB/Swiss-Prot:P50835" /translation="MNGSSRSYPRQMGYYYPQHMQGYYQQAAPGYLEQQLPQQHYGQQ DYYQPYAPIQPMPMQPPVFSNPYPIPRPNQQQPSQFQSIMSQFKKANGQFDFNKMMDT TGQVMSAMNQVGSLIKGFTSFFK*" /label="yppG CDS" gene complement(1931163..1931540) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /label="yppG gene" downshifts complement(1931196) /Source="Nicolas_upshifts" /id="D1167" /incds=0 /nref=10 /ntot=43 /MaxReadThrough="3.01854" /MaxDrop="4.7006" /score="0.85617333" /energy="-12.8" /TU="U1747" /idTUdmin="U1747" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" S_feature 1931538..1931683 /Source="Nicolas_S_feature" /locus_tag="new_2338392_2338537" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, C30" /AntisenseName="yppG" /AntisenseCor="0.96504903995490698" /AntisenseRegPval="-156.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S842" promotor_-10 complement(1931570..1931588) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1931589) /Source="Nicolas_upshifts" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1931602..1931611) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1931684..1931703 /Source="Nicolas_upshift_promotors" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1931685 /Source="Nicolas_upshifts" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="upshifts" CDS 1931728..1931916 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390108.1" /db_xref="EnsemblGenomes-Gn:BSU22260" /db_xref="EnsemblGenomes-Tr:CAB14143" /db_xref="InterPro:IPR025553" /db_xref="SubtiList:BG11447" /db_xref="UniProtKB/Swiss-Prot:P50834" /translation="MNVSYLSKRFAEMKKYETDCMNKLMDFAKFLYIQGHLSITEFRN SMKVLEANGAESPAYEMN*" /label="yppF CDS" gene 1931728..1931916 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /label="yppF gene" downshifts 1931932 /Source="Nicolas_upshifts" /id="D1168" /incds=0 /nref=112 /ntot=242 /MaxReadThrough="3.3677" /MaxDrop="5.69944" /score="0.283992322" /energy="-8.5" /TU="U1748" /idTUdmin="U1748" /TUdmin="-200" /isTUend="FALSE" /label="downshifts" CDS complement(1931955..1932326) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390109.1" /db_xref="EnsemblGenomes-Gn:BSU22270" /db_xref="EnsemblGenomes-Tr:CAB14144" /db_xref="InterPro:IPR014913" /db_xref="InterPro:IPR023351" /db_xref="PDB:2HFI" /db_xref="PDB:2IM8" /db_xref="SubtiList:BG11446" /db_xref="UniProtKB/Swiss-Prot:P50833" /translation="MLSQTLLEMTEQMIEVAEKGADRYQEGKNSNHSYDFFETIKPAV EENDELAARWAEGALELIKVRRPKYVHKEQIEAVKDNFLELVLQSYVHHIHKKRFKDI TESVLYTLHAVKDEIAREDSR*" /label="yppE CDS" gene complement(1931955..1932326) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /label="yppE gene" downshifts complement(1931988) /Source="Nicolas_upshifts" /id="D1169" /incds=0 /nref=158 /ntot=245 /MaxReadThrough="1.04225" /MaxDrop="5.78413" /score="-2.77698308" /energy="-10.3" /TU="NA" /idTUdmin="U1749" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1932338..1932357) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1932351) /Source="Nicolas_upshifts" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1932370..1932375) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1932372..1932617) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15687200; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390110.1" /db_xref="EnsemblGenomes-Gn:BSU22280" /db_xref="EnsemblGenomes-Tr:CAB14145" /db_xref="InterPro:IPR020252" /db_xref="SubtiList:BG11445" /db_xref="UniProtKB/Swiss-Prot:P50832" /translation="MSGYVCKTDILRMLSDIEDELTRAEQSLNHSVNALEAEMRETEN DRLSVLEEEIIDLHICINELYQSPEHRYAFEKVYRIG*" /label="yppD CDS" gene complement(1932372..1932617) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /label="yppD gene" promotor_-10 complement(1932643..1932661) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1932648) /Source="Nicolas_upshifts" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1932673..1932681) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1932767..1932773 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1932788..1932799 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1932795 /Source="Nicolas_upshifts" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="upshifts" CDS 1932816..1932920 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054585.1" /db_xref="EnsemblGenomes-Gn:BSU22290" /db_xref="EnsemblGenomes-Tr:CAE01459" /db_xref="GOA:Q7WY65" /db_xref="SubtiList:BG14177" /db_xref="UniProtKB/Swiss-Prot:Q7WY65" /translation="MKTRPKKAGQQKKTESKAIDSLDKKLGGPNRPST*" /label="sspM CDS" gene 1932816..1932920 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /label="sspM gene" downshifts 1932902 /Source="Nicolas_upshifts" /id="D1170" /incds=0 /nref=31 /ntot=49 /MaxReadThrough="1.6498" /MaxDrop="6.01285" /score="0.283992322" /energy="-8.5" /TU="NA" /idTUdmin="U1751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1932945..1933907) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390111.1" /db_xref="EnsemblGenomes-Gn:BSU22300" /db_xref="EnsemblGenomes-Tr:CAB14146" /db_xref="InterPro:IPR019658" /db_xref="SubtiList:BG10952" /db_xref="UniProtKB/Swiss-Prot:P39791" /translation="MNVQEQQAIRKLLSRIERQTKMKNADNISRTNAYKAFYDRHPEI KWSLLASFVSRNAGWSMTDLKGSLFQLGLRERQQKWFFLAYERANWLIFSDAYPQLLL YHWSKRVGKPLFHLLHVFGVSQFMSEEWTRFWHERNTERLMYALIINEQNTIQTPIIQ NPSFKKNVFDTIPFYLSDWFHFNTVIFPSSNGFFYGISVKRFSKAEERIRLGKQLSQL LFKPELFSSFYHFLHTVPHTGSRFDMEKMIGITKRTSPMLRTCYPELIHSLDGTKTDW FHGKIKKTFFRREELPKQIELTDWYLHKKRQLHALFAVEQWLKK*" /label="yppC CDS" gene complement(1932945..1933907) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /label="yppC gene" promotor_-35 1933075..1933084 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1933096..1933111 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1933096 /Source="Nicolas_upshifts" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1933100..1933435 /Source="Nicolas_S_feature" /locus_tag="new_2339954_2340289" /HighExp="T1.0H, T0.30H, T1.30H, H2O2, Paraq, LBGstat, T2.0H, T-0.40H, Salt, T2.30H" /AntisenseName="yppC" /AntisenseCor="-0.27690969451148201" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S843" promotor_-35 1933406..1933410 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1933426..1933445 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1933437..1933947 /Source="Nicolas_S_feature" /locus_tag="new_2340291_2340801" /HighExp="LBGstat, T1.0H, T1.30H, H2O2, T0.30H, Paraq, T2.0H, C30, G135, G180" /AntisenseName="yppC" /AntisenseCor="-0.312791370178301" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S844" upshifts 1933437 /Source="Nicolas_upshifts" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1933908..1934364) /Source="Nicolas_S_feature" /locus_tag="new_2340762_2341218_c" /HighExp="S8, S6, S7, S5, C30, G135, S4, BT, G180, Fru" /AntisenseName="recU" /AntisenseCor="-0.34780203121991599" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S845" CDS 1933948..1934568 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction resolvase" /protein_id="NP_390112.1" /db_xref="EnsemblGenomes-Gn:BSU22310" /db_xref="EnsemblGenomes-Tr:CAB14147" /db_xref="GOA:P39792" /db_xref="InterPro:IPR004612" /db_xref="InterPro:IPR011335" /db_xref="PDB:1RZN" /db_xref="PDB:1ZP7" /db_xref="PDB:5FDK" /db_xref="SubtiList:BG10953" /db_xref="UniProtKB/Swiss-Prot:P39792" /translation="MIRYPNGKTFQPKHSVSSQNSQKRAPSYSNRGMTLEDDLNETNK YYLTNQIAVIHKKPTPVQIVNVHYPKRSAAVIKEAYFKQSSTTDYNGIYKGRYIDFEA KETKNKTSFPLQNFHDHQIEHMKQVKAQDGICFVIISAFDQVYFLEADKLFYFWDRKE KNGRKSIRKDELEETAYPISLGYAPRIDYISIIEQLYFSPSSGAKG*" /label="recU CDS" gene 1933948..1934568 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /label="recU gene" promotor_-10 complement(1934353..1934364) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1934364) /Source="Nicolas_upshifts" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1934379..1934385) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1934590..1937334 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /EC_number="2.4.1.129" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan glycosyltransferase (penicillin-binding proteins 1A and 1B)" /protein_id="NP_390113.1" /db_xref="EnsemblGenomes-Gn:BSU22320" /db_xref="EnsemblGenomes-Tr:CAB14148" /db_xref="GOA:P39793" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR003961" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036116" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10954" /db_xref="UniProtKB/Swiss-Prot:P39793" /translation="MSDQFNSREARRKANSKSSPSPKKGKKRKKGGLFKKTLFTLLIL FVLGVVGGAVTFAVMVSDAPSLDESKLKTPYSSTIYDKNGKEIAEVGAEKRTYVSIDE IPDVVKEAFIATEDARFYEHHGIDPVRIGGALVANFKDGFGAEGGSTITQQVVKNSLL SHQKTLKRKVQEVWLSIQLERNYSKDEILEMYLNRIYFSPRAYGIGKAAEEFFGVTDL SKLTVEQAATLAGMPQSPTAYNPVKNPDKAEKRRNIVLSLMKKQGFISDSQYNKAKKV AVKDEGVVSQKEYEKASTNKYSAFVEEVMKEIDEKSDVDPSADGLKIYTTLDTKAQDK LDELMDGDTVGFTEGMQGGVTLLDTKNGEVRAIGAGRNQPVGGFNYATQTKAQPGSTI KPILDYGPVIENKKWSTYEQIDDSAYTYSNGKPIRDWDRKYLGPISMRYALAQSRNIP ALKAFQAVGKDTAVDFANGLGLGLTKDNVTEAYSIGGFGGNDGVSPLTMAGAYSAFGN NGTYNEPHFVKSIEFNDGTKLDLTPKSKSAMSDYTAFMITDMLKTAVKTGTGQLAQVP GVEVAGKTGTTNFDDNEVKRYNIASGGARDSWFVGYTPQYTAAVWTGMGENEAGKKSL SAEEQKVAKRIFAQLIADVDDGSGSFEKPDSVVEATVEKGSNPAKLAGPNTPSDKKLT EYFVKGTAPSTVSKTYEKEEKEETAKLSGLNVKYDKDNQSLTLSWNYDGDATFAVKQS VDGGSYSEIQNSSAKEAVISGVQPGSVYKFEVTAVSDDGKSTASTSYEVPKAEDDEDK KDQQQTDDEKQDDEKTQDDTQTDDSQKDDGQTDQDQTDDSTNDQDKKQDNTNTNPSDN NNQDQSNDNDNDNSNNQDTSDGDSNSGKNDSTGSDTNKNKTDTSNKTQTNSSSIEKTN *" /label="ponA CDS" gene 1934590..1937334 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /label="ponA gene" downshifts complement(1937004) /Source="Nicolas_upshifts" /id="D1171" /incds=1 /nref=1 /ntot=77 /MaxReadThrough="1.95969" /MaxDrop="2.87717" /score="24.9960782" /energy="-11.3" /TU="NA" /idTUdmin="U1755" /TUdmin=418 /isTUend="FALSE" /label="downshifts" downshifts 1937320 /Source="Nicolas_upshifts" /id="D1172" /incds=0 /nref=243 /ntot=302 /MaxReadThrough="1.61976" /MaxDrop="7.42523" /score="24.2831363" /energy="-14.6" /TU="U1753" /idTUdmin="U1752" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1937410..1937904) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390114.1" /db_xref="EnsemblGenomes-Gn:BSU22330" /db_xref="EnsemblGenomes-Tr:CAB14149" /db_xref="SubtiList:BG10955" /db_xref="UniProtKB/Swiss-Prot:P39789" /translation="MTQAKEVLASYEQYLRSLGQKSSSDMKKTLQTNPVYFDFCTELQ GDLPWEDSGKYVPLLFEVWDDIKASLLPVFQTRKSRCDQNEMLKGIVCLLASLHWTAG EPVKSLDWQELREKSYPAKPINWAERVEFILLKPTQYHCFIQLDELITEMKKHFYKYH AMNR*" /label="ypoC CDS" gene complement(1937410..1937904) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /label="ypoC gene" downshifts complement(1937423) /Source="Nicolas_upshifts" /id="D1173" /incds=0 /nref=116 /ntot=222 /MaxReadThrough="2.50883" /MaxDrop="5.43593" /score="29.5358766" /energy="-11.6" /TU="NA" /idTUdmin="U1755" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1937901..1938560) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /EC_number="4.2.99.18" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9808040, 11160880, 12682299, 21954439, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9808040, 11160880, 12682299, 21954439, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease III, apurinic apyrimidic DNA lyase" /protein_id="NP_390115.1" /db_xref="EnsemblGenomes-Gn:BSU22340" /db_xref="EnsemblGenomes-Tr:CAB14150" /db_xref="GOA:P39788" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR004035" /db_xref="InterPro:IPR004036" /db_xref="InterPro:IPR005759" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG10956" /db_xref="UniProtKB/Swiss-Prot:P39788" /translation="MLNLKQIEFCLDKIGDMFPHAECELVHSNPFELVVAVALSAQCT DALVNRVTKTLFQKYKRPEDYLAVPLEELQQDIKSIGLYRNKAKNIQKLSKMIIEDYG GEVPRDRDELVKLPGVGRKTANVVVSVAFGVPAIAVDTHVERVSKRLGICRWKDSVLE VEKTLMRKVPKEDWSVTHHRLIFFGRYHCKAQSPRCAECPLLSLCREGQKRDKKGLVK R*" /label="nth CDS" gene complement(1937901..1938560) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /label="nth gene" CDS complement(1938579..1939277) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /function="16.9: Replicate" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-remodelling primosomal protein" /protein_id="NP_390116.1" /db_xref="EnsemblGenomes-Gn:BSU22350" /db_xref="EnsemblGenomes-Tr:CAB14151" /db_xref="GOA:P39787" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="PDB:2V79" /db_xref="SubtiList:BG10957" /db_xref="UniProtKB/Swiss-Prot:P39787" /translation="MKKQQFIDMQEQGTSTIPNLLLTHYKQLGLNETELILLLKIKMH LEKGSYFPTPNQLQEGMSISVEECTNRLRMFIQKGFLFIEECEDQNGIKFEKYSLQPL WGKLYEYIQLAQNQTQERKAEGEQKSLYTIFEEEFARPLSPLECETLAIWQDQDQHDA QLIKHALKEAVLSGKLSFRYIDRILFEWKKNGLKTVEQAKIHSQKFRRVQAKQNEPQK EYKRQVPFYNWLEQ*" /label="dnaD CDS" gene complement(1938579..1939277) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /label="dnaD gene" S_feature complement(1939278..1939369) /Source="Nicolas_S_feature" /locus_tag="new_2346132_2346223_c" /HighExp="LoTm, G180, Cold, G135, LBGstat, G150, C30, Etha, Oxctl, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S846" CDS complement(1939370..1940662) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /EC_number="6.1.1.22" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparaginyl-tRNA synthetase" /protein_id="NP_390117.1" /db_xref="EnsemblGenomes-Gn:BSU22360" /db_xref="EnsemblGenomes-Tr:CAB14152" /db_xref="GOA:P39772" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004522" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10958" /db_xref="UniProtKB/Swiss-Prot:P39772" /translation="MKTTINQVYKHVGEEVTIGAWVANKRSSGKIAFLQLRDGTGFIQ GVVVKAEVEESIFQTAKSVTQETSLYIKGIVKEDERSPLGYELAVTDIEVIHEATDYP ITPKEHGTEFLMDHRHLWLRSKRQHAIMKIRNEIIRATYEFFNNEGFVKVDPPILTGS APEGTTELFATKYFDEDAYLSQSGQLYMEAAAMALGKVFSFGPTFRAEKSKTKRHLIE FWMIEPEMAFVEFEENLQVQENYVSFIVQSVLKNCKIELNTLGRDTSKLEQIKAPFPR ITYDEAIEFLKEKGFDDIEWGDDFGAPHETAIAEHYDKPVFITRYPTSLKPFYMQPAS DREDVVLCADLIAPEGYGEIIGGSERIHDMELLESRLKEHGLDSDAYKWYAELRKYGS VPHSGFGLGLERTVAWISGAPHVRETIPFPRLLNRLYP*" /label="asnS CDS" gene complement(1939370..1940662) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /label="asnS gene" S_feature complement(1940663..1940724) /Source="Nicolas_S_feature" /locus_tag="new_2347517_2347578_c" /HighExp="LBGexp, dia0, Lbexp, G150, G180, LPh, C30, Oxctl, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S847" promotor_-10 complement(1940724..1940743) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1940724) /Source="Nicolas_upshifts" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1940758..1940765) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1940806..1941987) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /EC_number="2.6.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:418816, 12670965, 22740702" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 418816, 12670965, 22740702; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anabolic oxaloacetate / glutamate aminotransferase" /protein_id="NP_390118.1" /db_xref="EnsemblGenomes-Gn:BSU22370" /db_xref="EnsemblGenomes-Tr:CAB14153" /db_xref="GOA:P53001" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11513" /db_xref="UniProtKB/Swiss-Prot:P53001" /translation="MKLAKRVSALTPSTTLAITAKAKELKAAGHDVIGLGAGEPDFNT PQHIIDAAVRSMNEGHTKYTPSGGLAELKNSIAEKFKRDQNIEYKPSQIIVCTGAKHA LYTLFQVILDEEDEVIIPTPYWVSYPEQVKLAGGKPVYVEGLEENHFKISPEQLKNAI TEKTKAIVINSPSNPTGVMYTEEELSALGEVCLEHDILIVSDEIYEKLTYGGKKHVSI AQLSDRLKEQTVIINGVSKSHSMTGWRIGYAAGSEDIIKAMTNLASHSTSNPTSIAQY GAIAAYNGPSEPLEEMREAFEHRLNTIYAKLIEIPGFSCVKPEGAFYLFPNAKEAAQS CGFKDVDEFVKALLEEEKVAIVPGSGFGSPENVRLSYATSLDLLEEAIERIKRFVEKH S*" /label="aspB CDS" gene complement(1940806..1941987) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /label="aspB gene" downshifts complement(1940810) /Source="Nicolas_upshifts" /id="D1174" /incds=0 /nref=48 /ntot=196 /MaxReadThrough="6.37268" /MaxDrop="4.0831" /score="5.04709675" /energy="-9.3" /TU="U1756,U1758,U1760,U1761,U1762" /idTUdmin="U1760" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(1942010..1942495) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /experiment="publication(s) with functional evidences, PMID:25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25954268; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="suppressor of tetracyclin sensitivity of an ezrAmutant" /protein_id="NP_390119.1" /db_xref="EnsemblGenomes-Gn:BSU22380" /db_xref="EnsemblGenomes-Tr:CAB14154" /db_xref="GOA:P54396" /db_xref="InterPro:IPR025711" /db_xref="PDB:2GU3" /db_xref="SubtiList:BG11502" /db_xref="UniProtKB/Swiss-Prot:P54396" /translation="MRKKALIFTVIFGIIFLAVLLVSASIYKSAMAQKEEGHEAAAAE AKKETDLAHVDQVETFVGKEKYYVVKGTDKKGTALYVWVPADKKAKILSKEAKEGISE DKAAKIIKDEGLVSKQKEVHLAREGNVLLWEVTYLDKEGQYSLSYVDFTTGKILKNIT P*" /label="tseB CDS" gene complement(1942010..1942495) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /label="tseB gene" promotor_-10 complement(1942443..1942462) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1942460) /Source="Nicolas_upshifts" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1942475..1942482) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1942504..1942674) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390120.1" /db_xref="EnsemblGenomes-Gn:BSU22390" /db_xref="EnsemblGenomes-Tr:CAB14155" /db_xref="InterPro:IPR012190" /db_xref="SubtiList:BG11501" /db_xref="UniProtKB/Swiss-Prot:P54395" /translation="MESKIEILSTINVEHSDDLYKIVDTLNRTLKRDNLMFGLALDEE NKNQAVFTIYRT*" /label="ypmA CDS" gene complement(1942504..1942674) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /label="ypmA gene" S_feature complement(1942675..1942746) /Source="Nicolas_S_feature" /locus_tag="new_2349529_2349600_c" /HighExp="H2O2, T0.30H, T0.0H, dia15, T-0.40H, T-1.10H, G135, T1.0H, G180, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.136042" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.85, 1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S848" promotor_-35 1942708..1942714 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1942729..1942748) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1942729..1942740 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1942736..1942810 /Source="Nicolas_S_feature" /locus_tag="new_2349590_2349664" /HighExp="S8, S6, S5, S7, nit, BT, G/S, Pyr, C30, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S849" upshifts 1942736 /Source="Nicolas_upshifts" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1942746) /Source="Nicolas_upshifts" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1942748..1942816) /Source="Nicolas_S_feature" /locus_tag="new_2349602_2349670_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, Salt, H2O2, T-1.10H, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S850" promotor_-35 complement(1942764..1942770) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1942780 /Source="Nicolas_upshifts" /id="D1175" /incds=0 /nref=8 /ntot=26 /MaxReadThrough="0.48859" /MaxDrop="6.02806" /score="18.4569945" /energy="-8.4" /TU="NA" /idTUdmin="U1757" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1942817..1945612) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8385320, 12060778, 17416902, 21546913, 22166102, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385320, 12060778, 17416902, 21546913, 22166102, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="damage inducible ATP-dependent 3'->5' nuclease" /protein_id="NP_390121.1" /db_xref="EnsemblGenomes-Gn:BSU22400" /db_xref="EnsemblGenomes-Tr:CAB14156" /db_xref="GOA:P54394" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006310" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11515" /db_xref="UniProtKB/Swiss-Prot:P54394" /translation="MNKQRFVVIDVETTGNSPKKGDKIIQIAAVVIENGQITERFSKY INPNKSIPAFIEQLTGISNQMVENEQPFEAVAEEVFQLLDGAYFVAHNIHFDLGFVKY ELHKAGFQLPDCEVLDTVELSRIVFPGFEGYKLTELSEELQLRHDQPHRADSDAEVTG LIFLEILEKLRQLPYPTLKQLRRLSQHFISDLTHLLDMFINENRHTEIPGYTRFSSFS VREPEAIDVRINEDENFSFEIESWEAGNEKALSELMPGYEKRDGQMMMMREVADAFAN REHALIEAPPGIGKTIGYLIPAALFAKKSKKPVIISTYSTLLQQQILTKDLPIVQDLF PFPVTAAILKGQSHYLCLYKFEQVLHEEDDNYDAVLTKAQLLVWLTETNTGDVAELNL PSGGKLLWDRLAYDDDSYKRSRSEHVIGFYERAKQIAMRSDLVITNHSLLLTDEGSHK KRLPESGTFIIDEAHHFERAASEHLGKRATYIELHTKLSRIGTLKEQGLLKKMRQLFQ RNSLPVDSFFELEEWLQHVQAESDAFFSSVHSFVKRRKPKEDLNRLVFKVNKESQDKS WSILTDGAERLCSMLTHLQQLFEAQSSLMEKHLKGMKSKTVFLADEYQRSMKGLQHYC QTLQKLFFGSDDDEAVWIEIDAKGAKNAVAIYAQPLEPGELLADQFFARKNSVVLTSA TLTVEGSFQFMIERLGLSDFFPRTMRIESPFSYDERMQVMIPKEMKSIQDTGQPEFIQ DTARYIELMAKEKQPKILVLFTSHDMLKKVHQELKHNMSASGIQLLAQGITGGSPGKL MKTFKTSNQAILLGTNHFWEGVDFPGDELTTVMIVRLPFRSPDHPLHAAKCELARKKG KNPFQTVSLPEAVLTFRQGIGRLLRSAGDKGTIIILDRRIKTAGYGRLFLDALPTTSV SEMTDSELEAYVAGEKE*" /label="dinG CDS" gene complement(1942817..1945612) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /label="dinG gene" promotor_-35 1943285..1943289 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1943286 /Source="Nicolas_upshifts" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1943291..1943295 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1943942..1943957) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(1943956) /Source="Nicolas_upshifts" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" promotor_-35 complement(1943970..1943979) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" S_feature complement(1945613..1945737) /Source="Nicolas_S_feature" /locus_tag="new_2352467_2352591_c" /HighExp="dia15, Diami, H2O2, Heat, LBGstat, C30, G180, G135, Oxctl, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S851" CDS complement(1945738..1946121) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /EC_number="4.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9169598, 12600205, 15033515, 26762040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9169598, 12600205, 15033515, 26762040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate 1-decarboxylase" /protein_id="NP_390122.1" /db_xref="EnsemblGenomes-Gn:BSU22410" /db_xref="EnsemblGenomes-Tr:CAB14157" /db_xref="GOA:P52999" /db_xref="InterPro:IPR003190" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG11493" /db_xref="UniProtKB/Swiss-Prot:P52999" /translation="MYRTMMSGKLHRATVTEANLNYVGSITIDEDLIDAVGMLPNEKV QIVNNNNGARLETYIIPGKRGSGVICLNGAAARLVQEGDKVIIISYKMMSDQEAASHE PKVAVLNDQNKIEQMLGNEPARTIL*" /label="panD CDS" gene complement(1945738..1946121) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /label="panD gene" CDS complement(1946123..1946983) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /EC_number="6.3.2.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17175524, 7037743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate synthetase" /protein_id="NP_390123.1" /db_xref="EnsemblGenomes-Gn:BSU22420" /db_xref="EnsemblGenomes-Tr:CAB14158" /db_xref="GOA:P52998" /db_xref="InterPro:IPR003721" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11520" /db_xref="UniProtKB/Swiss-Prot:P52998" /translation="MRQITDISQLKEAIKQYHSEGKSIGFVPTMGFLHEGHLTLADKA RQENDAVIMSIFVNPAQFGPNEDFEAYPRDIERDAALAENAGVDILFTPDAHDMYPGE KNVTIHVERRTDVLCGRSREGHFDGVAIVLTKLFNLVKPTRAYFGLKDAQQVAVVDGL ISDFFMDIELVPVDTVREEDGLAKSSRNVYLTAEERKEAPKLYRALQTSAELVQAGER DPEAVIKAAKDIIETTSGTIDYVELYSYPELEPVNEIAGKMILAVAVAFSKARLIDNI IIDIREMERI*" /label="panC CDS" gene complement(1946123..1946983) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /label="panC gene" CDS complement(1946985..1947818) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /EC_number="2.1.2.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 8096212; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ketopantoate hydroxymethyltransferase" /protein_id="NP_390124.1" /db_xref="EnsemblGenomes-Gn:BSU22430" /db_xref="EnsemblGenomes-Tr:CAB14159" /db_xref="GOA:P52996" /db_xref="InterPro:IPR003700" /db_xref="InterPro:IPR015813" /db_xref="SubtiList:BG11519" /db_xref="UniProtKB/Swiss-Prot:P52996" /translation="MKTKLDFLKMKESEEPIVMLTAYDYPAAKLAEQAGVDMILVGDS LGMVVLGLDSTVGVTVADMIHHTKAVKRGAPNTFIVTDMPFMSYHLSKEDTLKNAAAI VQESGADALKLEGGEGVFESIRALTLGGIPVVSHLGLTPQSVGVLGGYKVQGKDEQSA KKLIEDSIKCEEAGAMMLVLECVPAELTAKIAETLSIPVIGIGAGVKADGQVLVYHDI IGHGVERTPKFVKQYTRIDETIETAISGYVQDVRHRAFPEQKHSFQMNQTVLDGLYGG K*" /label="panB CDS" gene complement(1946985..1947818) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /label="panB gene" S_feature complement(1947819..1948026) /Source="Nicolas_S_feature" /locus_tag="new_2354673_2354880_c" /HighExp="LBGstat, dia15, Diami, H2O2, MG 15, Heat, Oxctl, MG 25, MG 10, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S852" promotor_-10 complement(1948021..1948040) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1948026) /Source="Nicolas_upshifts" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1948057..1948061) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1948064..1949041) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /EC_number="6.3.4.15" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12368242, 15459338, 28466579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 15459338, 28466579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin acetyl-CoA-carboxylase ligase and biotin regulon repressor (BirA-biotinoyl-5'-AMP)" /protein_id="NP_390125.1" /db_xref="EnsemblGenomes-Gn:BSU22440" /db_xref="EnsemblGenomes-Tr:CAB14160" /db_xref="GOA:P0CI75" /db_xref="InterPro:IPR003142" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004408" /db_xref="InterPro:IPR004409" /db_xref="InterPro:IPR008988" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR030855" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11206" /db_xref="UniProtKB/Swiss-Prot:P0CI75" /translation="MRSTLRKDLIELFSQAGNEFISGQKISDALGCSRTAVWKHIEEL RKEGYEVEAVRRKGYRLIKKPGKLSESEIRFGLKTEVMGQHLIYHDVLSSTQKTAHEL ANNNAPEGTLVVADKQTAGRGRMSRVWHSQEGNGVWMSLILRPDIPLQKTPQLTLLAA VAVVQGIEEAAGIQTDIKWPNDILINGKKTVGILTEMQAEEDRVRSVIIGIGINVNQQ PNDFPDELKDIATSLSQAAGEKIDRAGVIQHILLCFEKRYRDYMTHGFTPIKLLWESY ALGIGTNMRARTLNGTFYGKALGIDDEGVLLLETNEGIKKIYSADIELG*" /label="birA CDS" gene complement(1948064..1949041) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /label="birA gene" CDS complement(1949026..1950219) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /EC_number="2.7.7.72" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9829937, 16109934, 20360175, 22940585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829937, 16109934, 20360175, 22940585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA nucleotidyltransferase" /protein_id="NP_390126.1" /db_xref="EnsemblGenomes-Gn:BSU22450" /db_xref="EnsemblGenomes-Tr:CAB14161" /db_xref="GOA:P42977" /db_xref="InterPro:IPR002646" /db_xref="InterPro:IPR023068" /db_xref="InterPro:IPR032810" /db_xref="InterPro:IPR032828" /db_xref="SubtiList:BG11208" /db_xref="UniProtKB/Swiss-Prot:P42977" /translation="MEKVFIKALPVLRILIEAGHQAYFVGGAVRDSYMKRTIGDVDIA TDAAPDQVERLFQRTVDVGKEHGTIIVLWEDETYEVTTFRTESDYVDFRRPSEVQFIS SLEEDLKRRDLTINAMAMTADGKVLDYFGGKKDIDQKVIRTVGKPEDRFQEDALRMLR AVRFMSQLGFTLSPETEEAIAKEKSLLSHVSVERKTIEFEKLLQGRASRQALQTLIQT RLYEELPGFYHKRENLISTSEFPFFSLTSREELWAALLINLGIVLKDAPLFLKAWKLP GKVIKEAIHIADTFGQSLDAMTMYRAGKKALLSAAKISQLRQNEKLDEKKLKDIQYAY QNLPIKSLKDLDITGKDLLALRNRPAGKWVSEELQWIEQAVVTGKLSNQKKHIEEWLK TCGQH*" /label="cca CDS" gene complement(1949026..1950219) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /label="cca gene" CDS complement(1950224..1951357) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /EC_number="2.4.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751541, 20308541, 22569254, 27454321, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751541, 20308541, 22569254, 27454321, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate synthase;malate glycosyltransferase for bacillithiol synthesis" /protein_id="NP_390127.1" /db_xref="EnsemblGenomes-Gn:BSU22460" /db_xref="EnsemblGenomes-Tr:CAB14162" /db_xref="GOA:P42982" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR023881" /db_xref="InterPro:IPR028098" /db_xref="PDB:5D00" /db_xref="PDB:5D01" /db_xref="SubtiList:BG11213" /db_xref="UniProtKB/Swiss-Prot:P42982" /translation="MRKLKIGITCYPSVGGSGIIATELGKQLAEKGHEIHFITSSIPF RLNTYHPNIHFHEVEVNQYAVFKYPPYDLTLASKIAEVAERENLDIIHAHYALPHAVC AYLAKQMLKRNIGIVTTLHGTDITVLGYDPSLKDLIRFAIESSDRVTAVSSALAAETY DLIKPEKKIETIYNFIDERVYLKKNTAAIKEKHGILPDEKVVIHVSNFRKVKRVQDVI RVFRNIAGKTKAKLLLVGDGPEKSTACELIRKYGLEDQVLMLGNQDRVEDLYSISDLK LLLSEKESFGLVLLEAMACGVPCIGTNIGGIPEVIKNNVSGFLVDVGDVTAATARAMS ILEDEQLSNRFTKAAIEMLENEFSSKKIVSQYEQIYADLAEPE*" /label="bshA CDS" gene complement(1950224..1951357) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /label="bshA gene" CDS complement(1951354..1952064) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /EC_number="3.5.1.-" /function="4.10: Glutathione and analogs" /experiment="publication(s) with functional evidences, PMID:11004195, 20308541, 23894131, 28117687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004195, 20308541, 23894131, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate deacetylase 1; malate N-acetylglucosamine N-acetyl hydrolase" /protein_id="NP_390128.2" /db_xref="EnsemblGenomes-Gn:BSU22470" /db_xref="EnsemblGenomes-Tr:CAB14163" /db_xref="GOA:P42981" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023842" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG11212" /db_xref="UniProtKB/Swiss-Prot:P42981" /translation="MYNADVLAFGAHSDDVEIGMGGTIAKFVKQEKKVMICDLTEAEL SSNGTVSLRKEEAAEAARILGADKRIQLTLPDRGLIMSDQAIRSIVTVIRICRPKAVF MPYKKDRHPDHGNAAALVEEAIFSAGIHKYKDEKSLPAHKVSKVYYYMINGFHQPDFV IDISDTIEAKKQSLNAYKSQFIPSKDSVSTPLTNGYIEIVEAREKLYGKEAGVEYAEG FFSKRMLMLDHDVLGGEQ*" /label="bshBA CDS" gene complement(1951354..1952064) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /label="bshBA gene" CDS complement(1952057..1952470) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /EC_number="4.2.3.3" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxal synthase" /protein_id="NP_390129.1" /db_xref="EnsemblGenomes-Gn:BSU22480" /db_xref="EnsemblGenomes-Tr:CAB14164" /db_xref="GOA:P42980" /db_xref="InterPro:IPR004363" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR018148" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG11211" /db_xref="UniProtKB/Swiss-Prot:P42980" /translation="MKIALIAHDKKKQDMVQFTTAYRDILKNHDLYATGTTGLKIHEA TGLQIERFQSGPLGGDQQIGALIAANALDLVIFLRDPLTAQPHEPDVSALIRLCDVYS IPLATNMGTAEILVRTLDEGVFEFRDLLRGEEPNV*" /label="mgsA CDS" gene complement(1952057..1952470) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /label="mgsA gene" CDS complement(1952486..1953289) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /EC_number="1.17.1.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6422596, 9398235, 12682299, 20503968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(4S)-4-hydroxy-2,3,4, 5-tetrahydro-(2S)-dipicolinic acid (HTPA) dehydratase reductase" /protein_id="NP_390130.1" /db_xref="EnsemblGenomes-Gn:BSU22490" /db_xref="EnsemblGenomes-Tr:CAB14165" /db_xref="GOA:P42976" /db_xref="InterPro:IPR000846" /db_xref="InterPro:IPR022663" /db_xref="InterPro:IPR022664" /db_xref="InterPro:IPR023940" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11207" /db_xref="UniProtKB/Swiss-Prot:P42976" /translation="MSNETIKLVIAGPRGRMGQEAVKLAERTPHFDLVGAIDHTYDQQ KLSDVMPVESDAFIYTDIHACFTETQPDVLIDLTTPEIGKVHTKIALEHGVRPVVGTT GFSEADLKELTSLTEEKGIGAIIAPNFALGAILMMKFSKMAANYFEDVEIIELHHDQK LDAPSGTALKTAEMISEVRKEKQQGHPDEKEILPGARGAEQNGIRLHSVRLPGLIAHQ EVMFGMDGQTLQIRHDSYNRASFMSGVKLSVEQVMKIDQLVYGLENIID*" /label="dapB CDS" gene complement(1952486..1953289) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /label="dapB gene" CDS complement(1953301..1953636) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16390452, 20529853, 20944217, 21733847, 24339782, 26920050, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidized nucleotide pyrophosphohydrolase" /protein_id="NP_390131.1" /db_xref="EnsemblGenomes-Gn:BSU22500" /db_xref="EnsemblGenomes-Tr:CAB14166" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR012359" /db_xref="PDB:2GTA" /db_xref="SubtiList:BG11210" /db_xref="UniProtKB/Swiss-Prot:P42979" /translation="MSDKTMKDIQAEVDRYIGQFKEGYFSPLAMMARLTEELGELARE VNHRYGEKPKKATEDDKSMEEEIGDVLFVLVCLANSLDISLEEAHDRVMHKFNTRDKD RWTRKEEGK*" /label="ypjD CDS" gene complement(1953301..1953636) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /label="ypjD gene" promotor_-10 complement(1953656..1953675) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(1953666) /Source="Nicolas_upshifts" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" promotor_-35 complement(1953689..1953696) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" promotor_-35 1953705..1953712 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1953721..1953740) /Source="Nicolas_upshift_promotors" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1953726..1953745 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1953732 /Source="Nicolas_upshifts" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1953740) /Source="Nicolas_upshifts" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" CDS 1953776..1954648 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390132.2" /db_xref="EnsemblGenomes-Gn:BSU22510" /db_xref="EnsemblGenomes-Tr:CAB14167" /db_xref="GOA:P42978" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11209" /db_xref="UniProtKB/Swiss-Prot:P42978" /translation="MLGEIRLKNIFFILIGAAIFSFGLVHFNMQNNLAEGGFTGITLL LYALFHISPSISNLVLNIPIFFIGWRLLGRTMFVYTLVGTVALSLFLSIFQRYEIHMP LQHDLALAALFAGVFIGAGLGIIFKFGGTTGGVDIIARLVNKYFGIPMGRTMFAFDAC VIILSLLTYLSYKEAMYTLVAVFVAARLIDFIQEGGYAAKGATIISSKNDLIQKKILE EMERGVTILKGQGSYTKEDIDVLYCVVPKNELVMLKSVINSIDPHAFVAVSDVHDVLG EGFTLDENKNPLPR*" /label="ypjC CDS" gene 1953776..1954648 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /label="ypjC gene" CDS complement(1954690..1955484) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="sporulation septum-associated protein" /protein_id="NP_390133.1" /db_xref="EnsemblGenomes-Gn:BSU22520" /db_xref="EnsemblGenomes-Tr:CAB14168" /db_xref="GOA:P54393" /db_xref="InterPro:IPR014231" /db_xref="SubtiList:BG11500" /db_xref="UniProtKB/Swiss-Prot:P54393" /translation="MKRKLTICLLIALIFYNGNAKAAERGSLEELNDLSDTVFQMTRQ AKYEEALQVLEYFEKTLKSAEKKQQDPMLTGAQIRQITLGYNDMVRSLKQADTSDTQK LRAAAQFRMLMDAVDNRSDPLWGSLEKPIMEAFTELKRDVQKNGSTSFHEKWNEFISL YDLIYPSLTIDVSEDQLETVGKHIDVIEQEEFQQMTESTKLERLSLLQHDLKNVFDRV EEDDADPSLLWVIITTGSIIITALTYVGYRKYKAEKNKLKKRDYPK*" /label="ypjB CDS" gene complement(1954690..1955484) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /label="ypjB gene" downshifts complement(1954715) /Source="Nicolas_upshifts" /id="D1176" /incds=0 /nref=4 /ntot=106 /MaxReadThrough="1.96946" /MaxDrop="3.51024" /score="34.9661402" /energy="-11.3" /TU="NA" /idTUdmin="U1765" /TUdmin=198 /isTUend="FALSE" /label="downshifts" S_feature complement(1955485..1955552) /Source="Nicolas_S_feature" /locus_tag="new_2362339_2362406_c" /HighExp="LBGstat, C30, S0, LoTm, G180, G135, G150, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S853" CDS complement(1955553..1956110) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390134.1" /db_xref="EnsemblGenomes-Gn:BSU22530" /db_xref="EnsemblGenomes-Tr:CAB14169" /db_xref="GOA:P54392" /db_xref="InterPro:IPR009845" /db_xref="SubtiList:BG11499" /db_xref="UniProtKB/Swiss-Prot:P54392" /translation="MLILVLAINFLGTVYGYYWYLPQLLETPARFLIFVPDSPTATFF FLFVLLAFLMKRNAPLLEALALVTLVKYGLWAVAMNFLVLAVTGDLPWEGYMLIASHF AMAVQGVLYSPYFRFSFWHLAIAAVWTLHNDVIDYLFDMMPQYSMLSDYMTEIGYGTF WLSIFSIALAYFLVVSKKQTKLELM*" /label="ypjA CDS" gene complement(1955553..1956110) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /label="ypjA gene" S_feature complement(1956111..1956190) /Source="Nicolas_S_feature" /locus_tag="new_2362965_2363044_c" /HighExp="C30, UNK1, G135, BMM, G150, G180, Oxctl, LoTm, Paraq, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S854" downshifts complement(1956235) /Source="Nicolas_upshifts" /id="D1177" /incds=0 /nref=131 /ntot=215 /MaxReadThrough="3.97061" /MaxDrop="6.41485" /score="13.3880841" /energy="-8" /TU="U1765" /idTUdmin="U1767" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1956257..1957024) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome cc subunit)" /protein_id="NP_390135.1" /db_xref="EnsemblGenomes-Gn:BSU22540" /db_xref="EnsemblGenomes-Tr:CAB14170" /db_xref="GOA:P46913" /db_xref="InterPro:IPR005798" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012049" /db_xref="InterPro:IPR027387" /db_xref="InterPro:IPR036150" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG11327" /db_xref="UniProtKB/Swiss-Prot:P46913" /translation="MHRGKGMKFVGDSRIPAEKKPNIPKDYSEYPGKTEAFWPNFLLK EWMVGAVFLIGFLVLTIVHQPPLERMADPTDTGYIPLPDWYFLFLYQLLKYEYAAGSF TVVGAMIMPGLAFGALLLAPFLDRGTERRPWKRPVAVGMMLLAISAAVFLTWQSVATH DWAKAEEQGKITKEADIDTNAEGYKVFKEQGCISCHGDNLQGGAAGPSLVDSGLKPDE IKKIAVEGKGKMPAGVFKGNDKQLEELAKFISETTAK*" /label="qcrC CDS" gene complement(1956257..1957024) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /label="qcrC gene" CDS complement(1957059..1957733) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 15849754, 16850406; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome b subunit)" /protein_id="NP_390136.1" /db_xref="EnsemblGenomes-Gn:BSU22550" /db_xref="EnsemblGenomes-Tr:CAB14171" /db_xref="GOA:P46912" /db_xref="InterPro:IPR005797" /db_xref="InterPro:IPR016174" /db_xref="InterPro:IPR023530" /db_xref="InterPro:IPR027387" /db_xref="SubtiList:BG11326" /db_xref="UniProtKB/Swiss-Prot:P46912" /translation="MLNKIYDWVDERLDITPMWRDIADHEVPEHVNPAHHFSAFVYCF GGLTFFVTVIQVLSGMFLTMYYVPDIKNAWESVYYLQNEVAFGQIVRGMHHWGASLVI VMMFLHTLRVFFQGAYKKPRELNWIVGVLIFFVMLGLGFTGYLLPWDMKALFATKVGL QIAEATPLIGTQVKTLLAGHPDIVGAQTLTRFFAIHVFFLPAALFGLMAAHFIMIRKQ GISGPL*" /label="qcrB CDS" gene complement(1957059..1957733) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /label="qcrB gene" CDS complement(1957735..1958238) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /EC_number="1.10.2.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 24652282, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (iron-sulfur subunit)" /protein_id="NP_390137.1" /db_xref="EnsemblGenomes-Gn:BSU22560" /db_xref="EnsemblGenomes-Tr:CAB14172" /db_xref="GOA:P46911" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR014349" /db_xref="InterPro:IPR014909" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11325" /db_xref="UniProtKB/Swiss-Prot:P46911" /translation="MGGKHDISRRQFLNYTLTGVGGFMAASMLMPMVRFALDPVLKST GKQDMVQVVSVDELTKEPQRFDFKINQVDAWYESEESRSAWVFKNGDEIVALSPICKH LGCTVNWNSDPKNPNKFFCPCHYGLYEKDGTNVPGTPPLAPLDHYEQEVKDGFLYLGK AKPKGEG*" /label="qcrA CDS" gene complement(1957735..1958238) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /label="qcrA gene" downshifts 1958247 /Source="Nicolas_upshifts" /id="D1178" /incds=0 /nref=1 /ntot=80 /MaxReadThrough="1.24169" /MaxDrop="3.42621" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=3608 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1958302..1958321) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1958302) /Source="Nicolas_upshifts" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1958336..1958343) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1958381..1958827) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15743949" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390138.1" /db_xref="EnsemblGenomes-Gn:BSU22570" /db_xref="EnsemblGenomes-Tr:CAB14173" /db_xref="InterPro:IPR019615" /db_xref="SubtiList:BG11498" /db_xref="UniProtKB/Swiss-Prot:P54391" /translation="MRWRITDAKDYLQAKDYIDTAVIPLINIRVNNHFKMAAEKGEFT QLLSEELERQLKGRVYLLPPYTYVDRNEITVQGLKDLREELITEFPHVVLLTSDESWR AEDALGKMIVTSSVPLEHLNDSLKRKILDERTAEILNVLLQLWSTL*" /label="ypiF CDS" gene complement(1958381..1958827) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /label="ypiF gene" downshifts 1958830 /Source="Nicolas_upshifts" /id="D1179" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="0.94679" /MaxDrop="2.794" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=4191 /isTUend="FALSE" /label="downshifts" CDS complement(1958882..1959421) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16847875" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390139.1" /db_xref="EnsemblGenomes-Gn:BSU22580" /db_xref="EnsemblGenomes-Tr:CAB14174" /db_xref="InterPro:IPR011188" /db_xref="InterPro:IPR014957" /db_xref="InterPro:IPR014963" /db_xref="SubtiList:BG11497" /db_xref="UniProtKB/Swiss-Prot:P54390" /translation="MQTPVSVNEKKDFIRWFLNHYQLKRRECVWILNYLMSHDSLMEK VHFVEQAEFCPRGIIMSTHCVEEVPFRFYKENVMTTDAEKSFHDIRLNKQQDLFIQLN FRSAYSSPEYAAVLESNPHIPKNLFENKKDQGLAEQILEHAISTFQREKLLKDIDDAL DRHDKEAFEQLSRQLNQLT*" /label="ypiB CDS" gene complement(1958882..1959421) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /label="ypiB gene" downshifts complement(1958895) /Source="Nicolas_upshifts" /id="D1180" /incds=0 /nref=84 /ntot=250 /MaxReadThrough="5.68366" /MaxDrop="5.48142" /score="16.8021869" /energy="-11.2" /TU="U1766,U1767" /idTUdmin="U1768" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1959454..1959472) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(1959465) /Source="Nicolas_upshifts" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="upshifts" promotor_-35 complement(1959484..1959492) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" CDS complement(1959493..1960764) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390140.1" /db_xref="EnsemblGenomes-Gn:BSU22590" /db_xref="EnsemblGenomes-Tr:CAB14175" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11496" /db_xref="UniProtKB/Swiss-Prot:P54389" /translation="MNTLIQEAIKLVEAGETEKGLNTLSKAEKQLHDEDKAIAAQLYY EWGDVEKAISLISDLHDLYPNETELTNFYAELLIDIDEEEKALAVLETIPETDPSYPE SLLLMADLYQMQGLFEVSEQKLFQAKSILDNEPVIDFALGELYFAQGAYAKAVQYFKT TAEEQSEIGGVNVHQRLAESLSASGEFEDAIPWYEKAVDENPDPNTIFGYGFTALQAG LVKTAIKQLSDLKELDPSYTSLYMPLSKSYEAEGMYEEALKTAKEGIRYDEYNKELFL YAAKMALKIGKSEEGKKLLQEALALDPGFVEALHTLLAVYHKEEDYDQIIDLIQEVRS YGEEDPKYNWYLASAYTELEQYEEAKQSFEAAYLHYREDRDFLYEYASFLLEEGLQKE ALPLLKKVLEMDGANEELEETILRIEDEFSR*" /label="ypiA CDS" gene complement(1959493..1960764) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /label="ypiA gene" S_feature complement(1960765..1960832) /Source="Nicolas_S_feature" /locus_tag="new_2367619_2367686_c" /HighExp="dia15, Diami, dia5, Etha, H2O2, T1.30H, LPhT, T0.30H, T3.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF, SigA" /TUshortPSig="0.999, 0.999, 0.999, 1" /TUlongSig="Sig-, Sig-, SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.047, 0.994, 0.999, 1, 0.999, 1, 0.998" /label="S855" promotor_-10 complement(1960829..1960848) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1960832) /Source="Nicolas_upshifts" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1960862..1960869) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1960899..1960918) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(1960905) /Source="Nicolas_upshifts" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="upshifts" S_feature complement(1960907..1961051) /Source="Nicolas_S_feature" /locus_tag="new_2367761_2367905_c" /HighExp="S3, LoTm, M9-stat, S4, Etha, S5, T5.0H, BT, B36, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.047, 0.994" /TUlongSig="Sig-, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.999, 1, 0.999, 1, 0.998" /label="S856" promotor_-35 complement(1960929..1960936) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" promotor_-10 complement(1961033..1961051) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(1961051) /Source="Nicolas_upshifts" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="upshifts" promotor_-35 complement(1961067..1961072) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(1961100..1962386) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /EC_number="2.5.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3106153, 22938038, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvoylshikimate-3-phosphate synthase)" /protein_id="NP_390141.1" /db_xref="EnsemblGenomes-Gn:BSU22600" /db_xref="EnsemblGenomes-Tr:CAB14176" /db_xref="GOA:P20691" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR006264" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR023193" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10294" /db_xref="UniProtKB/Swiss-Prot:P20691" /translation="MKRDKVQTLHGEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPG ADCLSTIDCFRKMGVHIEQSSSDVVIHGKGIDALKEPESLLDVGNSGTTIRLMLGILA GRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKIDGRAGGEFTPLSVSGASLKGIDYVS PVASAQIKSAVLLAGLQAEGTTTVTEPHKSRDHTERMLSAFGVKLSEDQTSVSIAGGQ KLTAADIFVPGDISSAAFFLAAGAMVPNSRIVLKNVGLNPTRTGIIDVLQNMGAKLEI KPSADSGAEPYGDLIIETSSLKAVEIGGDIIPRLIDEIPIIALLATQAEGTTVIKDAA ELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKQTLKGGAAVSSHGDHRIGMMLG IASCITEEPIEIEHTDAIHVSYPTFFEHLNKLSKKS*" /label="aroA CDS" gene complement(1961100..1962386) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /label="aroA gene" downshifts complement(1961123) /Source="Nicolas_upshifts" /id="D1181" /incds=0 /nref=68 /ntot=212 /MaxReadThrough="3.64462" /MaxDrop="4.25336" /score="16.8021869" /energy="-11.2" /TU="U1770,U1772,U1773" /idTUdmin="U1775" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(1962397..1963512) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /EC_number="1.3.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106153, 3121591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106153, 3121591; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydrogenase" /protein_id="NP_390142.1" /db_xref="EnsemblGenomes-Gn:BSU22610" /db_xref="EnsemblGenomes-Tr:CAB14177" /db_xref="GOA:P20692" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003099" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10293" /db_xref="UniProtKB/Swiss-Prot:P20692" /translation="MNQMKDTILLAGLGLIGGSIALAIKKNHPGKRIIGIDISDEQAV AALKLGVIDDRADSFISGVKEAATVIIATPVEQTLVMLEELAHSGIEHELLITDVGST KQKVVDYADQVLPSRYQFVGGHPMAGSHKSGVAAAKEFLFENAFYILTPGQKTDKQAV EQLKNLLKGTNAHFVEMSPEEHDGVTSVISHFPHIVAASLVHQTHHSENLYPLVKRFA AGGFRDITRIASSSPAMWRDILLHNKDKILDRFDEWIREIDKIRTYVEQEDAENLFRY FKTAKDYRDGLPLRQKGAIPAFYDLYVDVPDHPGVISEITAILAAERISITNIRIIET REDINGILRISFQSDDDRKRAEQCIEARAEYETFYAD*" /label="tyrA CDS" gene complement(1962397..1963512) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /label="tyrA gene" CDS complement(1963561..1964643) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /EC_number="2.6.1.5" /EC_number="2.6.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4431, 418816, 824269, 11518529, 15102328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4431, 418816, 824269, 11518529, 15102328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol-phosphate aminotransferase; tyrosine/phenylalanine aminotransferase (promiscuous)" /protein_id="NP_390143.2" /db_xref="EnsemblGenomes-Gn:BSU22620" /db_xref="EnsemblGenomes-Tr:CAB14178" /db_xref="GOA:P17731" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR005861" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10292" /db_xref="UniProtKB/Swiss-Prot:P17731" /translation="MRIKEHLKQLKPYQPGKPIEAVKSEYGLDKVVKLASNENPYGCS EAAKEALHHEIQQLALYPDGYSAALRTRLSKHLNVSETSLIFGNGSDEIIQIICRAFL NDKTNTVTAAPTFPQYKHNAVIEGAEVREIALRPDGSHDLDAMLEAIDEQTQVVWICS PNNPTGTYTSEGELLAFLERVPSRVLVVLDEAYYEYVTAEDYPETVPLLSKYSNLMIL RTFSKAYGLAALRVGYGIADENLIRQIEPAREPFNTSRLGQAAAIAALDDQAFIASCV EQNNAGLQQYYDFAKTHGLKCYPSQTNFVLIDFKRPADELFQALLEKGYIVRSGNALG FPTSLRITIGTKEQNEEILAILAEIL*" /label="hisC CDS" gene complement(1963561..1964643) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /label="hisC gene" CDS complement(1964654..1965457) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (alpha subunit)" /protein_id="NP_390144.1" /db_xref="EnsemblGenomes-Gn:BSU22630" /db_xref="EnsemblGenomes-Tr:CAB14179" /db_xref="GOA:P07601" /db_xref="InterPro:IPR002028" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018204" /db_xref="SubtiList:BG10291" /db_xref="UniProtKB/Swiss-Prot:P07601" /translation="MFKLDLQPSEKLFIPFITAGDPVPEVSIELAKSLQKAGATALEL GVAYSDPLADGPVIQRASKRALDQGMNIVKAIELGGEMKKNGVNIPIILFTYYNPVLQ LNKEYFFALLRENHIDGLLVPDLPLEESNSLQEECKSHEVTYISLVAPTSESRLKTII EQAEGFVYCVSSLGVTGVRNEFNSSVYPFIRTVKNLSTVPVAVGFGISNREQVIKMNE ISDGVVVGSALVRKIEELKDRLISAETRNQALQEFEDYAMAFSGLYSLK*" /label="trpA CDS" gene complement(1964654..1965457) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /label="trpA gene" promotor_-10 complement(1965142..1965161) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(1965159) /Source="Nicolas_upshifts" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="upshifts" promotor_-35 complement(1965173..1965180) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(1965450..1966652) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (beta subunit)" /protein_id="NP_390145.2" /db_xref="EnsemblGenomes-Gn:BSU22640" /db_xref="EnsemblGenomes-Tr:CAB14180" /db_xref="GOA:P07600" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR006653" /db_xref="InterPro:IPR006654" /db_xref="InterPro:IPR023026" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10290" /db_xref="UniProtKB/Swiss-Prot:P07600" /translation="MYPYPNEIGRYGDFGGKFVPETLMQPLDEIQTAFKQIKDDPAFR EEYYKLLKDYSGRPTALTYADRVTEYLGGAKIYLKREDLNHTGSHKINNALGQALLAK KMGKTKIIAETGAGQHGVAAATVAAKFGFSCTVFMGEEDVARQSLNVFRMKLLGAEVV PVTSGNGTLKDATNEAIRYWVQHCEDHFYMIGSVVGPHPYPQVVREFQKMIGEEAKDQ LKRIEGTMPDKVVACVGGGSNAMGMFQAFLNEDVELIGAEAAGKGIDTPLHAATISKG TVGVIHGSLTYLIQDEFGQIIEPYSISAGLDYPGIGPEHAYLHKSGRVTYDSITDEEA VDALKLLSEKEGILPAIESAHALAKAFKLAKGMDRGQLILVCLSGRGDKDVNTLMNVL EEEVKAHV*" /label="trpB CDS" gene complement(1965450..1966652) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /label="trpB gene" CDS complement(1966633..1967280) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /EC_number="5.3.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylanthranilate isomerase" /protein_id="NP_390146.3" /db_xref="EnsemblGenomes-Gn:BSU22650" /db_xref="EnsemblGenomes-Tr:CAB14181" /db_xref="GOA:P20167" /db_xref="InterPro:IPR001240" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10289" /db_xref="UniProtKB/Swiss-Prot:P20167" /translation="MKKPALKYCGIRSLKDLQLAAESQADYLGFIFAESKRKVSPEDV KKWLNQVRVEKQVAGVFVNESIETMSRIAKSLKLDVIQLHGDEKPADAAALRKLTGCE IWKALHHQDNTTQEIARFKDNVDGFVIDSSVKGSRGGTGVAFSWECVPEYQQAAIGKR CFIAGGVNPDSITRLLKWQPEGIDLASGIEKNGQKDQNLMRLLEERMNRYVSISE*" /label="trpF CDS" gene complement(1966633..1967280) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /label="trpF gene" downshifts complement(1966727) /Source="Nicolas_upshifts" /id="D1182" /incds=1 /nref=30 /ntot=83 /MaxReadThrough="8.17917" /MaxDrop="5.75867" /score="2.96963632" /energy="-11.9" /TU="U1771,U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=616 /isTUend="FALSE" /label="downshifts" misc_feature complement(1966903..1966906) /Source="Nicolas_upshift_promotors" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1966903) /Source="Nicolas_upshifts" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" downshifts complement(1967123) /Source="Nicolas_upshifts" /id="D1183" /incds=1 /nref=1 /ntot=84 /MaxReadThrough="8.55417" /MaxDrop="3.4408" /score="2.96963632" /energy="-11.9" /TU="U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=220 /isTUend="FALSE" /label="downshifts" misc_feature 1967285..1968037 /created_by="AR/SM" /id="IIG_Bs01" /note="due to the curing of the trpC2 locus (auxotrophy) of the Delta6 strain by transformation with chromosomal DNA from donor Bsu 3NA multiple snp`s were transferred to the oroginal trpC locus" /modified_by="User" /label="IIG_Bs01" /note="Geneious type: MiniBacillus__exchange" CDS complement(1967285..1968037) /locus_tag="PG10_trpC_var_BEP06_07765" /inference="EXISTENCE: similar to AA sequence:RefSeq:WP_007409461.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="indole-3-glycerol phosphate synthase" /protein_id="ANY35339.1" /old_locus_tag="BSU_22660" /gene="trpC" /modified_by="User" /translation="MLEKIIKQKKEEVKTLVLPVEQPFEKRSFKEALASLNRFIGLIA EVKKASPSKGLIKENFVPVRIAKDYETAKADALSVLTDTPFFQGENSYLSDVKRAVSI PVLRKDFIIDSLQVEESRRIGADAILLIGEVLDPLHLHELYLEAGEKEMDVLVEVHDA TTLEQILKVFTPDILGINNRNLKTFETSIMQTEQIASLAPKESLLVSESGIGSLEHLT FVKEHGARAVLIGESLMRQTSQRKAIHALFRE*" /label="PG10_trpC_var_BEP06_07765" gene complement(1967285..1968037) /locus_tag="PG10_trpC_var_BEP06_07765" /old_locus_tag="BSU_22660" /gene="trpC" /modified_by="User" /label="PG10_trpC_var_BEP06_07765" misc_feature complement(1967318..1967320) /Source="Nicolas_upshift_promotors" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1967321 /Source="Nicolas_upshifts" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="upshifts" Polymorphism join(1967427,1967430) /Source="geneious" /ID="SNP_BsPG10_2374282_2374283" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change /CDS_Position=606 /Change="AG -> GT" /Codon_Change="TCC,TTG -> TCA,CTG" /Coverage="129 -> 130" /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="AG" /Variant_Nucleotides="GT" /Variant_P_Value="2e-203" /Variant_Raw_Frequency="128 -> 129" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967441,1967443) /Source="geneious" /ID="SNP_BsPG10_2374296_2374296" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="V -> A" /CDS_Position=593 /Change="A -> G" /Codon_Change="GTT -> GCT" /Coverage=119 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="3.2e-179" /Variant_Raw_Frequency=119 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967443,1967445) /Source="geneious" /ID="SNP_BsPG10_2374298_2374298" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=591 /Change="G -> A" /Codon_Change="CTC -> CTT" /Coverage=118 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="9.9e-148" /Variant_Raw_Frequency=116 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967468,1967470) /Source="geneious" /ID="SNP_BsPG10_2374323_2374323" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="K -> M" /CDS_Position=566 /Change="T -> A" /Codon_Change="AAG -> ATG" /Coverage=81 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="A" /Variant_P_Value="6.3e-98" /Variant_Raw_Frequency=81 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967470,1967474) /Source="geneious" /ID="SNP_BsPG10_2374325_2374327" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change="V -> I" /CDS_Position=562 /Change="TAC -> GAT" /Codon_Change="GTA -> ATC" /Coverage="79 -> 84" /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="TAC" /Variant_Nucleotides="GAT" /Variant_P_Value="2.3e-77" /Variant_Raw_Frequency="74 -> 78" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967476,1967478) /Source="geneious" /ID="SNP_BsPG10_2374331_2374331" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=558 /Change="T -> G" /Codon_Change="ACA -> ACC" /Coverage=70 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value="1e-63" /Variant_Raw_Frequency=70 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967485,1967487) /Source="geneious" /ID="SNP_BsPG10_2374340_2374340" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=549 /Change="C -> A" /Codon_Change="ACG -> ACT" /Coverage=59 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="A" /Variant_P_Value="1e-59" /Variant_Raw_Frequency=59 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967500,1967502) /Source="geneious" /ID="SNP_BsPG10_2374355_2374355" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=534 /Change="A -> G" /Codon_Change="AAT -> AAC" /Coverage=66 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="6e-64" /Variant_Raw_Frequency=65 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967503,1967505) /Source="geneious" /ID="SNP_BsPG10_2374358_2374358" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=531 /Change="A -> G" /Codon_Change="AAT -> AAC" /Coverage=63 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="3.3e-68" /Variant_Raw_Frequency=60 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967508,1967510) /Source="geneious" /ID="SNP_BsPG10_2374363_2374363" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="V -> I" /CDS_Position=526 /Change="C -> T" /Codon_Change="GTA -> ATA" /Coverage=65 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="3.9e-82" /Variant_Raw_Frequency=64 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967518,1967520) /Source="geneious" /ID="SNP_BsPG10_2374373_2374373" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=516 /Change="G -> A" /Codon_Change="GAC -> GAT" /Coverage=79 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="7.7e-116" /Variant_Raw_Frequency=78 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967521,1967523) /Source="geneious" /ID="SNP_BsPG10_2374376_2374376" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=513 /Change="G -> A" /Codon_Change="CCC -> CCT" /Coverage=92 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="4e-141" /Variant_Raw_Frequency=90 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967524,1967526) /Source="geneious" /ID="SNP_BsPG10_2374379_2374379" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=510 /Change="T -> C" /Codon_Change="ACA -> ACG" /Coverage=97 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="1.3e-165" /Variant_Raw_Frequency=97 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967530,1967532) /Source="geneious" /ID="SNP_BsPG10_2374385_2374385" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=504 /Change="C -> T" /Codon_Change="GTG -> GTA" /Coverage=109 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="4.3e-193" /Variant_Raw_Frequency=108 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967556,1967558) /Source="geneious" /ID="SNP_BsPG10_2374411_2374411" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="S -> T" /CDS_Position=478 /Change="A -> T" /Codon_Change="TCA -> ACA" /Coverage=148 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="T" /Variant_P_Value="2.9e-307" /Variant_Raw_Frequency=147 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967588,1967590) /Source="geneious" /ID="SNP_BsPG10_2374443_2374443" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="G -> E" /CDS_Position=446 /Change="C -> T" /Codon_Change="GGG -> GAG" /Coverage=161 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=161 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967641,1967643) /Source="geneious" /ID="SNP_BsPG10_2374496_2374496" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=393 /Change="C -> T" /Codon_Change="GAG -> GAA" /Coverage=174 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=174 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967689,1967691) /Source="geneious" /ID="SNP_BsPG10_2374544_2374544" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=345 /Change="T -> C" /Codon_Change="GTA -> GTG" /Coverage=168 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=167 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967704,1967708) /Source="geneious" /ID="SNP_BsPG10_2374559_2374558" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=0 /Amino_Acid_Change="-> I" /CDS_Position=331 /Change="AAT" /Codon_Change="-> ATT" /Coverage=164 /locus_tag="BSU_22660" /Protein_Effect="Insertion" /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="AAT" /Variant_P_Value="3.90000001038273e-316" /Variant_Raw_Frequency=147 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967722,1967724) /Source="geneious" /ID="SNP_BsPG10_2374574_2374574" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=315 /Change="A -> G" /Codon_Change="CTT -> CTC" /Coverage=155 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967731,1967733) /Source="geneious" /ID="SNP_BsPG10_2374583_2374583" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=306 /Change="A -> T" /Codon_Change="ATT -> ATA" /Coverage=153 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=152 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967743,1967745) /Source="geneious" /ID="SNP_BsPG10_2374595_2374595" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=294 /Change="A -> G" /Codon_Change="CGT -> CGC" /Coverage=128 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="4e-295" /Variant_Raw_Frequency=128 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967808,1967810) /Source="geneious" /ID="SNP_BsPG10_2374660_2374660" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="I -> L" /CDS_Position=229 /Change="T -> G" /Codon_Change="ATT -> CTT" /Coverage=131 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value="2.3e-302" /Variant_Raw_Frequency=128 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967818,1967820) /Source="geneious" /ID="SNP_BsPG10_2374670_2374670" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=219 /Change="C -> T" /Codon_Change="AAG -> AAA" /Coverage=126 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="1.6e-290" /Variant_Raw_Frequency=126 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967826,1967829) /Source="geneious" /ID="SNP_BsPG10_2374678_2374679" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change="EA -> ET" /CDS_Position=210 /Change="CC -> TT" /Codon_Change="GAG,GCT -> GAA,ACT" /Coverage="124 -> 130" /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="CC" /Variant_Nucleotides="TT" /Variant_P_Value="4.7e-253" /Variant_Raw_Frequency="119 -> 125" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967846,1967848) /Source="geneious" /ID="SNP_BsPG10_2374698_2374698" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="Q -> R" /CDS_Position=191 /Change="T -> C" /Codon_Change="CAG -> CGG" /Coverage=104 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="9e-228" /Variant_Raw_Frequency=101 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967862,1967864) /Source="geneious" /ID="SNP_BsPG10_2374714_2374714" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="D -> N" /CDS_Position=175 /Change="C -> T" /Codon_Change="GAT -> AAT" /Coverage=95 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency="1.1%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="2.8e-220" /Variant_Raw_Frequency=93 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967890,1967892) /Source="geneious" /ID="SNP_BsPG10_2374742_2374742" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=147 /Change="T -> C" /Codon_Change="GCA -> GCG" /Coverage=98 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="1.2e-260" /Variant_Raw_Frequency=97 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967905,1967907) /Source="geneious" /ID="SNP_BsPG10_2374757_2374757" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=132 /Change="G -> A" /Codon_Change="GCC -> GCT" /Coverage=197 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value /Variant_Raw_Frequency /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967930,1967932) /Source="geneious" /ID="SNP_BsPG10_2374782_2374782" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="P -> L" /CDS_Position=107 /Change="G -> A" /Codon_Change="CCG -> CTG" /Coverage=118 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value=0 /Variant_Raw_Frequency=118 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967947,1967949) /Source="geneious" /ID="SNP_BsPG10_2374799_2374799" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=90 /Change="C -> T" /Codon_Change="AAG -> AAA" /Coverage=133 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=131 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967962,1967964) /Source="geneious" /ID="SNP_BsPG10_2374814_2374814" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=75 /Change="C -> T" /Codon_Change="GAG -> GAA" /Coverage=130 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=130 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" CDS complement(1968030..1969046) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /EC_number="2.4.2.18" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 17114058; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="anthranilate phosphoribosyltransferase" /protein_id="NP_390148.2" /db_xref="EnsemblGenomes-Gn:BSU22670" /db_xref="EnsemblGenomes-Tr:CAB14183" /db_xref="GOA:P03947" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR005940" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="SubtiList:BG10288" /db_xref="UniProtKB/Swiss-Prot:P03947" /modified_by="User" /translation="MNRFLQLCVDGKTLTAGEAETLMNMMMAAEMTPSEMGGILSILA HRGETPEELAGFVKAMRAHALTVDGLPDIVDTCGTGGDGISTFNISTASAIVASAAGA KIAKHGNRSVSSKSGSADVLEELEVSIQTTPEKVKSSIETNNMGFLFAPLYHSSMKHV AGTRKELGFRTVFNLLGPLSNPLQAKRQVIGVYSVEKAGLMASALETFQPKHVMFVSS RDGLDELSITAPTDVIELKDGERREYTVSPEDFGFTNGRLEDLQVQSPKESAYLIQNI FENKSSSSALSITAFNAGAAIYTAGITASLKEGTELALETITSGGAAAQLERLKQKEE EIYA*" /label="trpD CDS" gene complement(1968030..1969046) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /modified_by="User" /label="trpD gene" CDS complement(1969018..1970565) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anthranilate synthase" /protein_id="NP_390149.1" /db_xref="EnsemblGenomes-Gn:BSU22680" /db_xref="EnsemblGenomes-Tr:CAB14184" /db_xref="GOA:P03963" /db_xref="InterPro:IPR005256" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10287" /db_xref="UniProtKB/Swiss-Prot:P03963" /translation="MNFQSNISAFLEDSLSHHTIPIVETFTVDTLTPIQMIEKLDREI TYLLESKDDTSTWSRYSFIGLNPFLTIKEEQGRFSAADQDSKSLYTGNELKEVLNWMN TTYKIKTPELGIPFVGGAVGYLSYDMIPLIEPSVPSHTKETDMEKCMLFVCRTLIAYD HETKNVHFIQYARLTGEETKNEKMDVFHQNHLELQNLIEKMMDQKNIKELFLSADSYK TPSFETVSSNYEKSAFMADVEKIKSYIKAGDIFQGVLSQKFEVPIKADAFELYRVLRI VNPSPYMYYMKLLDREIVGSSPERLIHVQDGHLEIHPIAGTRKRGADKAEDERLKVEL MKDEKEKAEHYMLVDLARNDIGRVAEYGSVSVPEFTKIVSFSHVMHIISVVTGRLKKG VHPVDALMSAFPAGTLTGAPKIRAMQLLQELEPTPRETYGGCIAYIGFDGNIDSCITI RTMSVKNGVASIQAGAGIVADSVPEAEYEESCNKAGALLKTIHIAEDMFHSKEDKADE QISTIVR*" /label="trpE CDS" gene complement(1969018..1970565) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /label="trpE gene" S_feature complement(1970644..1970775) /Source="Nicolas_S_feature" /locus_tag="new_2377495_2377626_c" /HighExp="Etha, S1, GM 25, GM 15, HiTm, Glu, MG-0.1, GM 60, M9-exp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.994, 0.647, 0.999, 1, 0.996" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.998" /label="S857" downshifts complement(1970687) /Source="Nicolas_upshifts" /id="D1184" /incds=0 /nref=61 /ntot=157 /MaxReadThrough="7.41666" /MaxDrop="5.25158" /score="2.96963632" /energy="-11.9" /TU="U1773,U1774,U1775,U1776" /idTUdmin="U1777" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1970766..1970785) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-10" upshifts complement(1970775) /Source="Nicolas_upshifts" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="upshifts" CDS complement(1970781..1971164) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate mutase" /protein_id="NP_390150.1" /db_xref="EnsemblGenomes-Gn:BSU22690" /db_xref="EnsemblGenomes-Tr:CAB14185" /db_xref="GOA:P19080" /db_xref="InterPro:IPR008243" /db_xref="InterPro:IPR035959" /db_xref="PDB:1COM" /db_xref="PDB:1DBF" /db_xref="PDB:1FNJ" /db_xref="PDB:1FNK" /db_xref="PDB:2CHS" /db_xref="PDB:2CHT" /db_xref="PDB:3ZO8" /db_xref="PDB:3ZOP" /db_xref="PDB:3ZP4" /db_xref="PDB:3ZP7" /db_xref="SubtiList:BG10286" /db_xref="UniProtKB/Swiss-Prot:P19080" /translation="MMIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQ MLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQD QIRHVYLEKVVVLRPDLSLTKNTEL*" /label="aroH CDS" gene complement(1970781..1971164) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /label="aroH gene" promotor_-35 complement(1970800..1970807) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-35" CDS complement(1971161..1972249) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /EC_number="4.2.3.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate synthase" /protein_id="NP_390151.1" /db_xref="EnsemblGenomes-Gn:BSU22700" /db_xref="EnsemblGenomes-Tr:CAB14186" /db_xref="GOA:P31102" /db_xref="InterPro:IPR016037" /db_xref="InterPro:IPR030960" /db_xref="InterPro:IPR030963" /db_xref="SubtiList:BG10285" /db_xref="UniProtKB/Swiss-Prot:P31102" /translation="MKTLHVQTASSSYPVFIGQGIRKKACELLTSLNRPLTRIMFVTD EEVDRLYGDEMLHLLQEKWPVKKVTVPSGEQAKSMDMYTKLQSEAIRFHMDRSSCIIA FGGGVVGDLAGFVAATFMRGIDFIQMPTTLLAHDSAVGGKVAVNHPLGKNLIGAFYQP KAVLYDTDFLRSLPEKELRSGMAEVIKHAFIYDRAFLEELLNIHSLRDITNDQLNDMI FKGISIKASVVQQDEKEEGIRAYLNFGHTLGHAVEAEYGYGQITHGDAVALGMQFALY ISEKTVGCEMDRKRLVSWLKSLGYPSQIRKETETSVLLNRMMNDKKTRGGKIQFIVLN ELGKVADHTFSRNELESWLNKWRLEETS*" /label="aroB CDS" gene complement(1971161..1972249) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /label="aroB gene" promotor_-10 complement(1971290..1971305) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(1971303) /Source="Nicolas_upshifts" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="upshifts" promotor_-35 complement(1971318..1971326) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(1972249..1973421) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /EC_number="4.2.3.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 10518299, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 10518299, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate synthase" /protein_id="NP_390152.3" /db_xref="EnsemblGenomes-Gn:BSU22710" /db_xref="EnsemblGenomes-Tr:CAB14187" /db_xref="GOA:P31104" /db_xref="InterPro:IPR000453" /db_xref="InterPro:IPR020541" /db_xref="InterPro:IPR035904" /db_xref="SubtiList:BG10284" /db_xref="UniProtKB/Swiss-Prot:P31104" /translation="MRYLTAGESHGPQLTTIIEGVPAGLYITEEDINFELARRQKGHG RGRRMQIEKDQAKIMSGVRHARTLGSPIALVVENNDWKHWTKIMGAAPITEDEEKEMK RQISRPRPGHADLNGAIKYNHRDMRNVLERSSARETTVRVAAGAVAKKILSELGIKVA GHVLQIGAVKAEKTEYTSIEDLQRVTEESPVRCYDEEAGKKMMAAIDEAKANGDSIGG IVEVIVEGMPVGVGSYVHYDRKLDSKLAAAVLSINAFKGVEFGIGFEAAGRNGSEVHD EIIWDEEKGYTRATNRLGGLEGGMTTGMPIVVRGVMKPIPTLYKPLKSVDIETKEPFS ASIERSDSCAVPAASVVAEAAVAWEIANAVVEQFGLDQIDRIRENVENMRKLSREF*" /label="aroF CDS" gene complement(1972249..1973421) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /label="aroF gene" promotor_-10 complement(1973456..1973475) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1973473) /Source="Nicolas_upshifts" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1973488..1973495) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1973496..1974266) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /EC_number="2.1.1.80" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis proteins (MCPs) methyltransferase" /protein_id="NP_390153.2" /db_xref="EnsemblGenomes-Gn:BSU22720" /db_xref="EnsemblGenomes-Tr:CAB14188" /db_xref="GOA:P31105" /db_xref="InterPro:IPR000780" /db_xref="InterPro:IPR022641" /db_xref="InterPro:IPR022642" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036804" /db_xref="PDB:5FTW" /db_xref="SubtiList:BG10283" /db_xref="UniProtKB/Swiss-Prot:P31105" /translation="MDTYSVFTTKWKQLTGVDLTLYKEAQMKRRLTSLYEKKGFQSFK DFAAALEKDQALLNETLDRMTINVSEFYRNYKRWEVLETAILPLIKTSRPLKIWSAAC STGEEPYTLAMLLDQQKGLPGYQILATDIDEKALEKAKKGVYQERSLQEVPLSVKDRY FTQNANRSYEVKTEIKKNITFKKHNLLADRYEQDFDLIVCRNVFIYFTESAKEELYLK MAHSLKKNGVLFVGSTEQIFNPEKFGLVPADTFFYQKR*" /label="cheR CDS" gene complement(1973496..1974266) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /label="cheR gene" promotor_-10 complement(1974292..1974311) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1974309) /Source="Nicolas_upshifts" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1974323..1974329) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" S_feature complement(1974341..1974502) /Source="Nicolas_S_feature" /locus_tag="new_2381192_2381353_c" /HighExp="M0t90, Lbstat, S0, Mt0, M0t45, M40t90, Lbtran, Mal, G/S, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.996, 0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S858" downshifts complement(1974384) /Source="Nicolas_upshifts" /id="D1185" /incds=0 /nref=26 /ntot=128 /MaxReadThrough="4.04342" /MaxDrop="4.7493" /score="29.2259705" /energy="-8.6" /TU="U1777,U1778,U1779,U1780" /idTUdmin="U1778" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" CDS complement(1974503..1974952) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /EC_number="2.7.4.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 11734624, 22720735, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside diphosphate kinase" /protein_id="NP_390154.1" /db_xref="EnsemblGenomes-Gn:BSU22730" /db_xref="EnsemblGenomes-Tr:CAB14189" /db_xref="GOA:P31103" /db_xref="InterPro:IPR001564" /db_xref="InterPro:IPR023005" /db_xref="InterPro:IPR034907" /db_xref="InterPro:IPR036850" /db_xref="SubtiList:BG10282" /db_xref="UniProtKB/Swiss-Prot:P31103" /translation="MMEKTFIMVKPDGVQRQLIGDILSRFERKGLQLAGAKLMRVTEQ MAEKHYAEHQGKPFFGELVEFITSGPVFAMVWEGENVIEVTRQLIGKTNPKEALPGTI RGDYGMFVGKNIIHGSDSLESAEREINIFFKNEELVSYQQLMAGWIY*" /label="ndk CDS" gene complement(1974503..1974952) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /label="ndk gene" promotor_-10 complement(1974995..1975014) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(1975002) /Source="Nicolas_upshifts" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="upshifts" promotor_-35 complement(1975027..1975034) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(1975068..1976114) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /EC_number="2.5.1.30" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component II" /protein_id="NP_390155.1" /db_xref="EnsemblGenomes-Gn:BSU22740" /db_xref="EnsemblGenomes-Tr:CAB14190" /db_xref="GOA:P31114" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR014119" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG10281" /db_xref="UniProtKB/Swiss-Prot:P31114" /translation="MLNIIRLLAESLPRISDGNENTDVWVNDMKFKMAYSFLNDDIDV IERELEQTVRSDYPLLSEAGLHLLQAGGKRIRPVFVLLSGMFGDYDINKIKYVAVTLE MIHMASLVHDDVIDDAELRRGKPTIKAKWDNRIAMYTGDYMLAGSLEMMTRINEPKAH RILSQTIVEVCLGEIEQIKDKYNMEQNLRTYLRRIKRKTALLIAVSCQLGAIASGADE KIHKALYWFGYYVGMSYQIIDDILDFTSTEEELGKPVGGDLLQGNVTLPVLYALKNPA LKNQLKLINSETTQEQLEPIIEEIKKTDAIEASMAVSEMYLQKAFQKLNTLPRGRARS SLAAIAKYIGKRKF*" /label="hepT CDS" gene complement(1975068..1976114) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /label="hepT gene" CDS complement(1976056..1976757) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /EC_number="2.1.1.163" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16279806, 9045837, 9139683, 21513522, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16279806, 9045837, 9139683, 21513522, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="demethylmenaquinone methyltransferase" /protein_id="NP_390156.1" /db_xref="EnsemblGenomes-Gn:BSU22750" /db_xref="EnsemblGenomes-Tr:CAB14191" /db_xref="GOA:P31113" /db_xref="InterPro:IPR004033" /db_xref="InterPro:IPR014122" /db_xref="InterPro:IPR023576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10280" /db_xref="UniProtKB/Swiss-Prot:P31113" /translation="MQDSKEQRVHGVFEKIYKNYDQMNSVISFQQHKKWRDKTMRIMN VKEGAKALDVCCGTADWTIALAKAAGKSGEIKGLDFSENMLSVGEQKVKDGGFSQIEL LHGNAMELPFDDDTFDYVTIGFGLRNVPDYLTVLKEMRRVVKPGGQVVCLETSQPEMF GFRQAYFMYFKYIMPFFGKLFAKSYKEYSWLQESARDFPGMKELAGLFEEAGLKNVKY HSFTGGVAATHIGWK*" /label="menG CDS" gene complement(1976056..1976757) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /label="menG gene" CDS complement(1976764..1977519) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /EC_number="2.5.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component I" /protein_id="NP_390157.1" /db_xref="EnsemblGenomes-Gn:BSU22760" /db_xref="EnsemblGenomes-Tr:CAB14192" /db_xref="GOA:P31112" /db_xref="InterPro:IPR009920" /db_xref="SubtiList:BG10279" /db_xref="UniProtKB/Swiss-Prot:P31112" /translation="MQDIYGTLANLNTKLKQKLSHPYLAKHISAPKIDEDKLLLFHAL FEEADIKNNDRENYIVTAMLVQSALDTHDEVTTARVIKRDENKNRQLTVLAGDYFSGL YYSLLSEMKDIYMIRTLATAIKEINEHKIRLYDRSFKDENDFFESVGIVESALFHRVA EHFNLPRWKKLSSDFFVFKRLMNGNDAFLDVIGSFIQLGKTKEEILEDCFKKAKNSIE SLLPLNSPIQNILINRLKTISQDQTYHQKVEEG*" /label="hepS CDS" gene complement(1976764..1977519) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /label="hepS gene" S_feature complement(1977520..1977605) /Source="Nicolas_S_feature" /locus_tag="new_2384371_2384456_c" /HighExp="H2O2, G150, G180, Paraq, Oxctl, G135, T-4.40H, Lbexp, T-3.40H, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S859" promotor_-10 complement(1977594..1977613) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1977605) /Source="Nicolas_upshifts" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1977624..1977631) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1977683..1977910) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15099736, 15588817, 16285852, 16306262, 17114058, 28069823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15099736, 15588817, 16285852, 16306262, 17114058, 28069823; Product type r : regulator" /codon_start=1 /transl_table=11 /product="tryptophan operon RNA-binding attenuation protein (TRAP)" /protein_id="NP_390158.1" /db_xref="EnsemblGenomes-Gn:BSU22770" /db_xref="EnsemblGenomes-Tr:CAB14193" /db_xref="GOA:P19466" /db_xref="InterPro:IPR000824" /db_xref="InterPro:IPR016031" /db_xref="InterPro:IPR023558" /db_xref="PDB:1WAP" /db_xref="PDB:3ZZQ" /db_xref="PDB:4B27" /db_xref="SubtiList:BG10278" /db_xref="UniProtKB/Swiss-Prot:P19466" /translation="MNQKHSSDFVVIKAVEDGVNVIGLTRGTDTKFHHSEKLDKGEVI IAQFTEHTSAIKVRGEALIQTAYGEMKSEKK*" /label="mtrB CDS" gene complement(1977683..1977910) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /label="mtrB gene" downshifts complement(1977704) /Source="Nicolas_upshifts" /id="D1186" /incds=0 /nref=22 /ntot=162 /MaxReadThrough="6.02348" /MaxDrop="4.385" /score="8.50521108" /energy="-10.5" /TU="U1779,U1780" /idTUdmin="U1781" /TUdmin=1499 /isTUend="FALSE" /label="downshifts" CDS complement(1977932..1978504) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1551827, 12559918, 14717702, 17032654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1551827, 12559918, 14717702, 17032654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_390159.1" /db_xref="EnsemblGenomes-Gn:BSU22780" /db_xref="EnsemblGenomes-Tr:CAB14194" /db_xref="GOA:P19465" /db_xref="InterPro:IPR001474" /db_xref="InterPro:IPR018234" /db_xref="InterPro:IPR020602" /db_xref="SubtiList:BG10277" /db_xref="UniProtKB/Swiss-Prot:P19465" /translation="MKEVNKEQIEQAVRQILEAIGEDPNREGLLDTPKRVAKMYAEVF SGLNEDPKEHFQTIFGENHEELVLVKDIAFHSMCEHHLVPFYGKAHVAYIPRGGKVTG LSKLARAVEAVAKRPQLQERITSTIAESIVETLDPHGVMVVVEAEHMCMTMRGVRKPG AKTVTSAVRGVFKDDAAARAEVLEHIKRQD*" /label="folEA CDS" gene complement(1977932..1978504) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /label="folEA gene" promotor_-10 complement(1978533..1978552) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1978543) /Source="Nicolas_upshifts" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" S_feature complement(1978545..1978628) /Source="Nicolas_S_feature" /locus_tag="new_2385396_2385479_c" /HighExp="Oxctl, G150, G180, G135, LBGexp, Paraq, LPh, H2O2, aero, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S860" promotor_-35 complement(1978565..1978571) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" downshifts complement(1978673) /Source="Nicolas_upshifts" /id="D1187" /incds=0 /nref=33 /ntot=254 /MaxReadThrough="6.68474" /MaxDrop="5.1938" /score="8.50521108" /energy="-10.5" /TU="U1780" /idTUdmin="U1781" /TUdmin=530 /isTUend="FALSE" /label="downshifts" CDS complement(1978692..1978970) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /function="16.1: Circulate" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617; Product type f: factor" /codon_start=1 /transl_table=11 /product="non-specific DNA-binding protein HBsu" /protein_id="NP_390160.1" /db_xref="EnsemblGenomes-Gn:BSU22790" /db_xref="EnsemblGenomes-Tr:CAB14195" /db_xref="GOA:P08821" /db_xref="InterPro:IPR000119" /db_xref="InterPro:IPR010992" /db_xref="InterPro:IPR020816" /db_xref="SubtiList:BG10276" /db_xref="UniProtKB/Swiss-Prot:P08821" /translation="MNKTELINAVAEASELSKKDATKAVDSVFDTILDALKNGDKIQL IGFGNFEVRERSARKGRNPQTGEEIEIPASKVPAFKPGKALKDAVAGK*" /label="hbs CDS" gene complement(1978692..1978970) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /label="hbs gene" S_feature complement(1978971..1979196) /Source="Nicolas_S_feature" /locus_tag="new_2385822_2386047_c" /HighExp="dia5, C90, T-0.40H, G/S, S1, Salt, Lbexp, dia15, T-1.40H, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S861" promotor_-10 complement(1979178..1979197) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1979196) /Source="Nicolas_upshifts" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1979214..1979219) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1979344..1980822) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11160095, 17114257, 17427285, 24810258, 26387458, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160095, 17114257, 17427285, 24810258, 26387458, 28408070; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="morphogenetic stage IV sporulation protein" /protein_id="NP_390161.1" /db_xref="EnsemblGenomes-Gn:BSU22800" /db_xref="EnsemblGenomes-Tr:CAB14196" /db_xref="GOA:P35149" /db_xref="InterPro:IPR014201" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10275" /db_xref="UniProtKB/Swiss-Prot:P35149" /translation="MEKVDIFKDIAERTGGDIYLGVVGAVRTGKSTFIKKFMELVVLP NISNEADRARAQDELPQSAAGKTIMTTEPKFVPNQAMSVHVSDGLDVNIRLVDCVGYT VPGAKGYEDENGPRMINTPWYEEPIPFHEAAEIGTRKVIQEHSTIGVVITTDGTIGDI ARSDYIEAEERVIEELKEVGKPFIMVINSVRPYHPETEAMRQDLSEKYDIPVLAMSVE SMRESDVLSVLREALYEFPVLEVNVNLPSWVMVLKENHWLRESYQESVKETVKDIKRL RDVDRVVGQFSEFEFIESAGLAGIELGQGVAEIDLYAPDHLYDQILKEVVGVEIRGRD HLLELMQDFAHAKTEYDQVSDALKMVKQTGYGIAAPALADMSLDEPEIIRQGSRFGVR LKAVAPSIHMIKVDVESEFAPIIGTEKQSEELVRYLMQDFEDDPLSIWNSDIFGRSLS SIVREGIQAKLSLMPENARYKLKETLERIINEGSGGLIAIIL*" /label="spoIVA CDS" gene complement(1979344..1980822) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /label="spoIVA gene" downshifts complement(1979357) /Source="Nicolas_upshifts" /id="D1188" /incds=0 /nref=59 /ntot=76 /MaxReadThrough="3.43222" /MaxDrop="7.13908" /score="13.6316529" /energy="-9.2" /TU="U1781" /idTUdmin="U1782" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1980823..1980984) /Source="Nicolas_S_feature" /locus_tag="new_2387674_2387835_c" /HighExp="S3, S4, S5, S6, LoTm, S7, B36, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S862" promotor_-10 complement(1980971..1980989) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-10" upshifts complement(1980996) /Source="Nicolas_upshifts" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="upshifts" CDS complement(1981003..1981737) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein of unknown function" /protein_id="NP_390162.1" /db_xref="EnsemblGenomes-Gn:BSU22810" /db_xref="EnsemblGenomes-Tr:CAB14197" /db_xref="SubtiList:BG10274" /db_xref="UniProtKB/Swiss-Prot:P39911" /translation="MGKLKCAIIFAAVVFLSGCLYPNERKSSVHAIPYQDQLKQVQSA VDEFQKANGGLLPIQTKDMSTPLYQKYPIDFNRLAPRYIAEPPSTAFESGGDYQYVLV DVENDPTVKLIDLKMAEKIRDVKLRIQMYRQEHQYPPYKDVLSRDLFTLDEKKLGDGS SLTVTSPISGNSLPLMIDGDGEIYADYRTELASCLKKSKKTFKPGTEIQDMIWHETPF VPAFSVKYTVNDKQEPVFLENDMKKE*" /label="yphF CDS" gene complement(1981003..1981737) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /label="yphF gene" promotor_-35 complement(1981004..1981009) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-35" downshifts complement(1981029) /Source="Nicolas_upshifts" /id="D1189" /incds=0 /nref=6 /ntot=78 /MaxReadThrough="6.50932" /MaxDrop="4.759" /score="15.8109079" /energy="-12.7" /TU="U1782" /idTUdmin="U1783" /TUdmin=1100 /isTUend="FALSE" /label="downshifts" CDS complement(1981759..1981962) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390163.1" /db_xref="EnsemblGenomes-Gn:BSU22820" /db_xref="EnsemblGenomes-Tr:CAB14198" /db_xref="GOA:P50744" /db_xref="InterPro:IPR020076" /db_xref="SubtiList:BG11444" /db_xref="UniProtKB/Swiss-Prot:P50744" /translation="MNLALMKMWFALGSMGLMFLAVASIYLSRFKCQNRFLKIAISSF AYMCMLISGIIVFVVVFSGPVNE*" /label="yphE CDS" gene complement(1981759..1981962) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /label="yphE gene" promotor_-10 complement(1981998..1982017) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1982019) /Source="Nicolas_upshifts" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1982031..1982038) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1982084..1982283) /Source="Nicolas_S_feature" /locus_tag="new_2388935_2389134_c" /HighExp="S7, S8, S6, C30, BT, G135, G180, Oxctl, Cold, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, Sig-" /TUshortPSig="1, 1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S863" downshifts complement(1982127) /Source="Nicolas_upshifts" /id="D1190" /incds=0 /nref=264 /ntot=295 /MaxReadThrough="2.22999" /MaxDrop="8.05743" /score="26.216597" /energy="-14.1" /TU="NA" /idTUdmin="U1783" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1982258..1982277) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1982283) /Source="Nicolas_upshifts" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1982291..1982300) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1982300..1983337) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /EC_number="1.1.1.94" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592341, 12682299, 15557260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592341, 12682299, 15557260; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent glycerol-3-phosphate dehydrogenase" /protein_id="NP_390164.1" /db_xref="EnsemblGenomes-Gn:BSU22830" /db_xref="EnsemblGenomes-Tr:CAB14199" /db_xref="GOA:P46919" /db_xref="InterPro:IPR006109" /db_xref="InterPro:IPR006168" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR011128" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11366" /db_xref="UniProtKB/Swiss-Prot:P46919" /translation="MKKVTMLGAGSWGTALALVLTDNGNEVCVWAHRADLIHQINELH ENKDYLPNVKLSTSIKGTTDMKEAVSDADVIIVAVPTKAIREVLRQAVPFITKKAVFV HVSKGIEPDSLLRISEIMEIELPSDVRKDIVVLSGPSHAEEVGLRHPTTVTASSKSMR AAEEVQDLFINHNFRVYTNPDIIGVEIGGALKNIIALAAGITDGLGYGDNAKAALITR GLAEIARLGTKMGGNPLTFSGLTGVGDLIVTCTSVHSRNWRAGNLLGKGYKLEDVLEE MGMVVEGVRTTKAAYQLSKKYDVKMPITEALHQVLFNGQKVETAVESLMARGKTHEME DLVNTFENQVK*" /label="gpsA CDS" gene complement(1982300..1983337) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /label="gpsA gene" CDS complement(1983355..1984665) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /EC_number="3.6.5.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase essential for ribosome 50S subunit assembly (maturation of the 50S subunit central protoberance)" /protein_id="NP_390165.1" /db_xref="EnsemblGenomes-Gn:BSU22840" /db_xref="EnsemblGenomes-Tr:CAB14200" /db_xref="GOA:P50743" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR016484" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031166" /db_xref="InterPro:IPR032859" /db_xref="PDB:2HJG" /db_xref="PDB:4DCS" /db_xref="PDB:4DCT" /db_xref="PDB:4DCU" /db_xref="PDB:4DCV" /db_xref="PDB:4KYU" /db_xref="PDB:5X4B" /db_xref="SubtiList:BG11443" /db_xref="UniProtKB/Swiss-Prot:P50743" /translation="MGKPVVAIVGRPNVGKSTIFNRIAGERISIVEDTPGVTRDRIYS SAEWLNYDFNLIDTGGIDIGDEPFLAQIRQQAEIAMDEADVIIFMVNGREGVTAADEE VAKILYRTKKPVVLAVNKLDNTEMRANIYDFYSLGFGEPYPISGTHGLGLGDLLDAVA EHFKNIPETKYNEEVIQFCLIGRPNVGKSSLVNAMLGEERVIVSNVAGTTRDAVDTSF TYNQQEFVIVDTAGMRKKGKVYETTEKYSVLRALKAIDRSEVVAVVLDGEEGIIEQDK RIAGYAHEAGKAVVIVVNKWDAVDKDESTMKEFEENIRDHFQFLDYAPILFMSALTKK RIHTLMPAIIKASENHSLRVQTNVLNDVIMDAVAMNPTPTHNGSRLKIYYATQVSVKP PSFVVFVNDPELMHFSYERFLENRIRDAFGFEGTPIKIFARARK*" /label="der CDS" gene complement(1983355..1984665) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /label="der gene" S_feature complement(1984666..1984790) /Source="Nicolas_S_feature" /locus_tag="new_2391517_2391641_c" /HighExp="Cold, G180, G150, Oxctl, G135, C30, LBGexp, Paraq, dia0, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S864" promotor_-10 complement(1984776..1984795) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1984790) /Source="Nicolas_upshifts" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1984810..1984813) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1984819..1985013) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097755.1" /db_xref="EnsemblGenomes-Gn:BSU22849" /db_xref="EnsemblGenomes-Tr:CAX52654" /db_xref="UniProtKB/Swiss-Prot:C0H445" /translation="MSESLTKVILSVITTNRNRVAGGAPVFFCNDQKEMELFAKNLEA ILDGIAHRIGDDVYLIVKHF*" /label="ypzH CDS" gene complement(1984819..1985013) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /label="ypzH gene" CDS complement(1985010..1985903) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390166.1" /db_xref="EnsemblGenomes-Gn:BSU22850" /db_xref="EnsemblGenomes-Tr:CAB14201" /db_xref="GOA:P50742" /db_xref="InterPro:IPR025918" /db_xref="SubtiList:BG11442" /db_xref="UniProtKB/Swiss-Prot:P50742" /translation="MSDYIYPIIAGVIAGIATRLYMLKTDYRQYPTYVHGKVIHIALG LIAAGLGAIIMPALLQEEFTAITFLTLAATQFRDVRNMERNTLTQMDSYELVSRGSTY IEGIAIAFESRNYIVIFTALLTTSAYVFLSIWAAVIAAVVCFLLAMKFMSGSVLKDIV DIEYIKPRFDGPGLFVDNIYMMNIGLPEKQELILKHGMGFILTPKNFNSAATIANLGQ RQAILFDVSNVLGVYRDSGEPSLTPIAKRDLNDGRVAVFVLPQIHHPETAVQIISNVP TLENAIRMPTEFIKNQDKVIG*" /label="yphB CDS" gene complement(1985010..1985903) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /label="yphB gene" CDS complement(1985900..1986499) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390167.1" /db_xref="EnsemblGenomes-Gn:BSU22860" /db_xref="EnsemblGenomes-Tr:CAB14202" /db_xref="GOA:P50741" /db_xref="InterPro:IPR014617" /db_xref="SubtiList:BG11441" /db_xref="UniProtKB/Swiss-Prot:P50741" /translation="MEQFYYYWSMWFLWVLTTFIFEKTKRRIAVSVFILTNIILSIHD IALYFSLNAAYLMFFVCGCVYAGYLGMYRFRYIMVYLTLVAAYAFVYLFALYDPVWFI IKPEWAAVILIVLLTASVERNFEKQLVLFVLGMCQGELVYSFVIQKLAGAMAVGGFQW LNACSAGMILLFGISKYEHLASQIGQKSKRSNKGATKMS*" /label="yphA CDS" gene complement(1985900..1986499) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /label="yphA gene" promotor_-35 1986372..1986378 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1986387..1986570 /Source="Nicolas_S_feature" /locus_tag="new_2393238_2393421" /HighExp="S5, S8, S6, S7, BT, S4, ferm, nit, Pyr, G/S" /AntisenseName="yphA" /AntisenseCor="0.73324773408178501" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.6" /TUlongSig="NA" /TUlongPSig="NA" /label="S865" upshifts 1986389 /Source="Nicolas_upshifts" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1986392..1986403 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1986510..1986528) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1986529) /Source="Nicolas_upshifts" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1986544..1986549) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1986577..1986708 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="YP_003097756.2" /db_xref="EnsemblGenomes-Gn:BSU22869" /db_xref="EnsemblGenomes-Tr:CAX52655" /db_xref="InterPro:IPR025414" /db_xref="UniProtKB/Swiss-Prot:C0H446" /translation="MGKDRQEKKLKASGRVESDRDQSIHYDGATSLEQNGRFKKRKS* " /label="ypzI CDS" gene 1986577..1986708 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /label="ypzI gene" downshifts 1986696 /Source="Nicolas_upshifts" /id="D1191" /incds=0 /nref=37 /ntot=122 /MaxReadThrough="0.20384" /MaxDrop="6.94664" /score="3.33160455" /energy="-13.2" /TU="NA" /idTUdmin="U1785" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1986751..1987800) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /EC_number="5.3.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12798687, 14745175, 15206931" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12798687, 14745175, 15206931; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl diphosphate isomerase (typeII)" /protein_id="NP_390168.3" /db_xref="EnsemblGenomes-Gn:BSU22870" /db_xref="EnsemblGenomes-Tr:CAB14203" /db_xref="GOA:P50740" /db_xref="InterPro:IPR000262" /db_xref="InterPro:IPR011179" /db_xref="InterPro:IPR013785" /db_xref="PDB:1P0K" /db_xref="PDB:1P0N" /db_xref="SubtiList:BG11440" /db_xref="UniProtKB/Swiss-Prot:P50740" /translation="MTRAERKRQHINHALSIGQKRETGLDDITFVHVSLPDLALEQVD ISTKIGELSSSSPIFINAMTGGGGKLTYEINKSLARAASQAGIPLAVGSQMSALKDPS ERLSYEIVRKENPNGLIFANLGSEATAAQAKEAVEMIGANALQIHLNVIQEIVMPEGD RSFSGALKRIEQICSRVSVPVIVKEVGFGMSKASAGKLYEAGAAAVDIGGYGGTNFSK IENLRRQRQISFFNSWGISTAASLAEIRSEFPASTMIASGGLQDALDVAKAIALGASC TGMAGHFLKALTDSGEEGLLEEIQLILEELKLIMTVLGARTIADLQKAPLVIKGETHH WLTERGVNTSSYSVR*" /label="fni CDS" gene complement(1986751..1987800) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /label="fni gene" downshifts complement(1986771) /Source="Nicolas_upshifts" /id="D1192" /incds=0 /nref=209 /ntot=250 /MaxReadThrough="1.39069" /MaxDrop="4.82362" /score="15.2467448" /energy="-13.2" /TU="NA" /idTUdmin="U1788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1987675) /Source="Nicolas_upshifts" /id="D1193" /incds=1 /nref=45 /ntot=237 /MaxReadThrough="6.15611" /MaxDrop="4.91722" /score="13.2731686" /energy="-15.7" /TU="U1788,U1789,U1790" /idTUdmin="U1788" /TUdmin="-904" /isTUend="FALSE" /label="downshifts" CDS complement(1987813..1988961) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 9862121, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA degradation presenting factor (ribosomal protein S1 homolog)" /protein_id="NP_390169.1" /db_xref="EnsemblGenomes-Gn:BSU22880" /db_xref="EnsemblGenomes-Tr:CAB14204" /db_xref="GOA:P38494" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11005" /db_xref="UniProtKB/Swiss-Prot:P38494" /translation="MTEEMNQIDVQVPEVGDVVKGIVTKVEDKHVDVEIINVKQSGII PISELSSLHVEKASDVVKVDDELDLKVTKVEDDALILSKRAVDADRAWEDLEKKFETK EVFEAEVKDVVKGGLVVDIGVRGFIPASLVEAHFVEDFTDYKGKTLSLLVVELDRDKN RVILSHRAVVESEQANKKQELLQSLEVGSVLDGKVQRLTDFGAFVDIGGIDGLVHISQ LSHSHVEKPSDVVEEGQEVKVKVLSVDRDNERISLSIKDTLPGPWNQIGEKVKPGDVL EGTVQRLVSFGAFVEILPGVEGLVHISQISNKHIGTPHEVLEEGQTVKVKVLDVNENE ERISLSMRELEETPKADQEDYRQYQAKEETSTGFQLGDLIGDKLNKLK*" /label="rpfA CDS" gene complement(1987813..1988961) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /label="rpfA gene" misc_feature 1988142..1988145 /Source="Nicolas_upshift_promotors" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1988169 /Source="Nicolas_upshifts" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1988235 /Source="Nicolas_upshifts" /id="D1194" /incds=1 /nref=1 /ntot=124 /MaxReadThrough="1.88188" /MaxDrop="2.8624" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1988939 /Source="Nicolas_upshifts" /id="D1195" /incds=0 /nref=3 /ntot=200 /MaxReadThrough="1.33117" /MaxDrop="3.08345" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=704 /isTUend="FALSE" /label="downshifts" S_feature complement(1988962..1989101) /Source="Nicolas_S_feature" /locus_tag="new_2395813_2395952_c" /HighExp="C90, Salt, Etha, Lbtran, HiOs, M40t90, S1, LBGtran, LoTm, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.999, 0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S866" promotor_-10 complement(1989100..1989119) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1989101) /Source="Nicolas_upshifts" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1989103..1989193) /Source="Nicolas_S_feature" /locus_tag="new_2395954_2396044_c" /HighExp="G135, G180, LBGexp, C30, Cold, Oxctl, dia0, G150, Paraq, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40511799999999998" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S867" promotor_-35 complement(1989134..1989141) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1989194..1989868) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /EC_number="2.7.4.25" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8576266, 9179491, 9862121, 11827479, 12682299, 16880539" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576266, 9179491, 9862121, 11827479, 12682299, 16880539; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidylate kinase" /protein_id="NP_390170.1" /db_xref="EnsemblGenomes-Gn:BSU22890" /db_xref="EnsemblGenomes-Tr:CAB14205" /db_xref="GOA:P38493" /db_xref="InterPro:IPR003136" /db_xref="InterPro:IPR011994" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11004" /db_xref="UniProtKB/Swiss-Prot:P38493" /translation="MEKKLSIAIDGPAAAGKSTVAKIVAEKKSYIYIDTGAMYRAITY AALQENVDLTDEEKLAELLKRTDIELITTKDGQKVFVNGTDVTEAIRTDEISNQVSIA AKHRSVREEMVKRQQQLGEKGGVVMDGRDIGTHVLPNAEVKIFLLASVEERAKRRYEE NVKKGFDVNYETLIEEIARRDKLDSEREVSPLRKAEDALEIDTTSLSIQEVADKILEA VEQKSR*" /label="cmk CDS" gene complement(1989194..1989868) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /label="cmk gene" S_feature complement(1989869..1989946) /Source="Nicolas_S_feature" /locus_tag="new_2396720_2396797_c" /HighExp="S4, S5, S7, S8, S6, dia15, S3, Diami, dia5, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S868" CDS complement(1989947..1990123) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390171.1" /db_xref="EnsemblGenomes-Gn:BSU22900" /db_xref="EnsemblGenomes-Tr:CAB14206" /db_xref="InterPro:IPR035281" /db_xref="SubtiList:BG11003" /db_xref="UniProtKB/Swiss-Prot:P38492" /translation="MKTFERLLIKLLFIQAIILLGVQFLFHYQHIEPYVSKVIQYEGV DKMEENNRIETFKH*" /label="ypfB CDS" gene complement(1989947..1990123) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /label="ypfB gene" promotor_-10 complement(1990135..1990153) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1990152) /Source="Nicolas_upshifts" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1990168..1990174) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1990168..1990821) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16249258, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16249258, 23893111, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic di-GMP receptor" /protein_id="NP_390172.1" /db_xref="EnsemblGenomes-Gn:BSU22910" /db_xref="EnsemblGenomes-Tr:CAB14207" /db_xref="GOA:P38491" /db_xref="InterPro:IPR009875" /db_xref="InterPro:IPR009926" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG11002" /db_xref="UniProtKB/Swiss-Prot:P38491" /translation="MIEIGENVLLEYIEENELKKAKSKAVSIENNELLIAYPVDVVTG RTVILHNDMEVTVEFVGKDEVPYRFISRIKGKVKDKLQMICLEMPPREKMKRIQRRQY VRTDAVLDVQIQPGNEEEIRTLSYNISAGGIAVVLADGLSFQSGESLRLIIRLPEEEH TRQIETEAVVRRIFNDPKSEKRKMTLEYSEIAAGDQQALLQYCIRRQLNKRRKARME* " /label="dgrA CDS" gene complement(1990168..1990821) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /label="dgrA gene" promotor_-10 complement(1990851..1990870) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1990864) /Source="Nicolas_upshifts" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1990886..1990890) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1990914..1992266) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination membrane component" /protein_id="NP_390173.1" /db_xref="EnsemblGenomes-Gn:BSU22920" /db_xref="EnsemblGenomes-Tr:CAB14208" /db_xref="GOA:P38490" /db_xref="InterPro:IPR014239" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG11001" /db_xref="UniProtKB/Swiss-Prot:P38490" /translation="MIRGILIAVLGIAIVGTGYWGYKEHQEKDAVLLHAENNYQRAFH ELTYQVDQLHDKIGTTLAMNSQKSLSPALIDVWRITSEAHNSVSQLPLTLMPFNKTEE LLSKIGDFSYKTSVRDLDQKPLDKNEYTSLNKLYQQSEDIQNELRHVQHLVMSKNLRW MDVEMALASDEKQSDNTIINSFKTVEKNVGAFSTGTDLGPSFTSTKKEEKGFSHLKGK QISEQEAKQIAERFAPDDNYSIKVVKSGKKTNRDVYSISMKDPDHKAVIYMDITKKGG HPVYLIQNREVKDQKISLNDGSNRALAFLKKNGFETDDLEIDESAQYDKIGVFSYVPV ENKVRMYPEAIRMKVALDDGEVVGFSARDFLTSHRKRTIPKPAITEAEAKSKLNKNVQ VRETRLALITNELGQEVLCYEMLGTIENDTFRMYINAKDGSEEKVEKLKNAEPIYKDL *" /label="sleC CDS" gene complement(1990914..1992266) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /label="sleC gene" downshifts complement(1990929) /Source="Nicolas_upshifts" /id="D1196" /incds=0 /nref=21 /ntot=44 /MaxReadThrough="0.647060000000002" /MaxDrop="5.74199" /score="16.6521528" /energy="-10.1" /TU="NA" /idTUdmin="U1791" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1992301..1993218) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination cortex-lytic enzyme" /protein_id="NP_390174.1" /db_xref="EnsemblGenomes-Gn:BSU22930" /db_xref="EnsemblGenomes-Tr:CAB14209" /db_xref="GOA:P50739" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR011105" /db_xref="InterPro:IPR014224" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11439" /db_xref="UniProtKB/Swiss-Prot:P50739" /translation="MKSKGSIMACLILFSFTITTFINTETISAFSNQVIQRGATGDDV VELQARLQYNGYYNGKIDGVYGWGTYWAVRNFQDQFGLKEVDGLVGAKTKQTLICKSK YYREYVMEQLNKGNTFTHYGKIPLKYQTKPSKAATQKARQQAEARQKQPAEKTTQKPK ANANKQQNNTPAKARKQDAVAANMPGGFSNNDIRLLAQAVYGEARGEPYEGQVAIAAV ILNRLNSPLFPNSVAGVIFEPLAFTAVADGQIYMQPNETAREAVLDAINGWDPSEEAL YYFNPDTATSPWIWGRPQIKRIGKHIFCE*" /label="sleB CDS" gene complement(1992301..1993218) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /label="sleB gene" downshifts complement(1992689) /Source="Nicolas_upshifts" /id="D1197" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.35344" /MaxDrop="4.29326" /score="-3.16364421" /energy="-21.7" /TU="U1791,U1792" /idTUdmin="U1793" /TUdmin=682 /isTUend="FALSE" /label="downshifts" misc_feature complement(1992840..1992847) /Source="Nicolas_upshift_promotors" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1992843) /Source="Nicolas_upshifts" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1993256..1993267) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1993265) /Source="Nicolas_upshifts" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1993281..1993287) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1993357..1994013) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /EC_number="3.4.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protease required for RsiW anti-sigma(W) degradation" /protein_id="NP_390175.1" /db_xref="EnsemblGenomes-Gn:BSU22940" /db_xref="EnsemblGenomes-Tr:CAB14210" /db_xref="GOA:P50738" /db_xref="InterPro:IPR023596" /db_xref="InterPro:IPR026898" /db_xref="SubtiList:BG11438" /db_xref="UniProtKB/Swiss-Prot:P50738" /translation="MFAIISAGIAPGIALLSYFYLKDQYDNEPVHMVLRSFFLGVVLV FPIMFIQYVLEKENVGGGSFFVSFLSSGFLEESLKWFILMISVYPHAHFDEHYDGIVY GASVSLGFATLENILYLIGHGVEHAFVRALLPVSCHALIGVIMGFYLGKARFSADKAR VKWLTLSLVVPSLLHGSYDFILTALSNWIYYMLPFMVFLWWFGLRKAKKARSVNMMQV *" /label="prsW CDS" gene complement(1993357..1994013) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /label="prsW gene" downshifts complement(1993371) /Source="Nicolas_upshifts" /id="D1198" /incds=0 /nref=239 /ntot=262 /MaxReadThrough="0.9181" /MaxDrop="6.61797" /score="-3.16364421" /energy="-21.7" /TU="NA" /idTUdmin="U1793" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1994038..1994057) /Source="Nicolas_upshift_promotors" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1994053) /Source="Nicolas_upshifts" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1994133..1995107) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /EC_number="1.8.-.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacillithiol biosynthesis thiol disulfide oxidoreductase" /protein_id="NP_390176.2" /db_xref="EnsemblGenomes-Gn:BSU22950" /db_xref="EnsemblGenomes-Tr:CAB14211" /db_xref="GOA:P50736" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR023856" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11436" /db_xref="UniProtKB/Swiss-Prot:P50736" /translation="MIQEKAIIIGGGPCGLSAAIHLKQIGIDALVIEKGNVVNSIYNY PTHQTFFSSSEKLEIGDVAFITENRKPVRIQALSYYREVVKRKNIRVNAFEMVRKVTK TQNNTFVIETSKETYTTPYCIIATGYYDHPNYMGVPGEDLPKVFHYFKEGHPYFDKDV VVIGGKNSSVDAALELVKSGARVTVLYRGNEYSPSIKPWILPEFEALVRNGTIRMEFG ACVEKITENEVVFRSGEKELITIKNDFVFAMTGYHPDHQFLEKIGVEIDKETGRPFFN EETMETNVEGVFIAGVIAAGNNANEIFIENGRFHGGHIAAEIAKRENH*" /label="ypdA CDS" gene complement(1994133..1995107) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /label="ypdA gene" downshifts complement(1994141) /Source="Nicolas_upshifts" /id="D1199" /incds=0 /nref=239 /ntot=263 /MaxReadThrough="3.524" /MaxDrop="6.45954" /score="27.4058676" /energy="-12.2" /TU="U1796" /idTUdmin="U1796" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-35 1994961..1994966 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1994982..1995000 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1994992..1995185 /Source="Nicolas_S_feature" /locus_tag="new_2401843_2402036" /HighExp="S8, S6, S7, S4, S5, C30, S3, BT, B36, C90" /AntisenseName="ypdA" /AntisenseCor="-0.487730736536516" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S869" upshifts 1994992 /Source="Nicolas_upshifts" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="upshifts" downshifts 1995143 /Source="Nicolas_upshifts" /id="D1200" /incds=0 /nref=13 /ntot=27 /MaxReadThrough="1.93985" /MaxDrop="5.69954" /score="23.7306175" /energy="-9.3" /TU="NA" /idTUdmin="U1794" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1995216..1996499) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 18326565, 22178969, 22720735, 25610436" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 18326565, 22178969, 22720735, 25610436; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cryptic glutamate dehydrogenase (active after removal of a 9 bp insert)" /protein_id="NP_390177.2" /db_xref="EnsemblGenomes-Gn:BSU22960" /db_xref="EnsemblGenomes-Tr:CAB14212" /db_xref="GOA:P50735" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K8Z" /db_xref="SubtiList:BG11435" /db_xref="UniProtKB/Swiss-Prot:P50735" /translation="MAADRNTGHTEEDKLDVLKSTQTVIHKALEKLGYPEEVYELLKE PMRLLTVKIPVRMDDGSVKIFTGYRAQHNDSVGPTKGGIRFHPNVTEKEVKAVKALSI WMSLKCGIIDLPYGGGKGGIVCDPRDMSFRELERLSRGYVRAISQIVGPTKDVPAPDV FTNSQIMAWMMDEYSRIDEFNSPGFITGKPLVLGGSHGRESATAKGVTICIKEAAKKR GIDIKGARVVVQGFGNAGSYLAKFMHDAGAKVVGISDAYGGLYDPEGLDIDYLLDRRD SFGTVTKLFNDTITNQELLELDCDILVPAAIENQITEENAHNIRAKIVVEAANGPTTL EGTKILSDRDILLVPDVLASAGGVTVSYFEWVQNNQGFYWSEEEVEEKLEKMMVKSFN NIYEMANNRRIDMRLAAYMVGVRKMAEASRFRGWI*" /label="gudB CDS" gene complement(1995216..1996499) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /label="gudB gene" downshifts complement(1995219) /Source="Nicolas_upshifts" /id="D1201" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="7.92262" /MaxDrop="4.04542" /score="18.1400723" /energy="-9.3" /TU="U1796" /idTUdmin="U1797" /TUdmin=1345 /isTUend="FALSE" /label="downshifts" promotor_-35 1995257..1995263 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1995275..1995279 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1995275 /Source="Nicolas_upshifts" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1996542..1996561) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1996563) /Source="Nicolas_upshifts" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1996576..1996583) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1996655..1997239) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914365, 19801546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914365, 19801546; Product type f: factor" /codon_start=1 /transl_table=11 /product="adaptor to ClpC; regulator of competence and sporulation" /protein_id="NP_390178.1" /db_xref="EnsemblGenomes-Gn:BSU22970" /db_xref="EnsemblGenomes-Tr:CAB14213" /db_xref="GOA:P50734" /db_xref="InterPro:IPR008681" /db_xref="PDB:3JTN" /db_xref="PDB:3JTO" /db_xref="SubtiList:BG11434" /db_xref="UniProtKB/Swiss-Prot:P50734" /translation="MRLERLNYNKIKIFLTLDDLTDRGLTKEDLWKDSFKVHQLFKDM MNEANTELGFEANGPIAVEVYSLQAQGMVVIVTKNQDADSEDDEYDDDYIEMQVKLDE SADIIYQFHSFEDIIQLSESLQRIGITGGTVYHYDGQYFLSLEDLGSHTAEGVVAVLA EYGNPTTLTIYRLQEYGKLIMDGNAVETIQTHFS*" /label="mecB CDS" gene complement(1996655..1997239) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /label="mecB gene" downshifts complement(1996657) /Source="Nicolas_upshifts" /id="D1202" /incds=0 /nref=258 /ntot=274 /MaxReadThrough="3.02006" /MaxDrop="7.92719" /score="23.8885529" /energy="-7.1" /TU="U1797" /idTUdmin="U1797" /TUdmin="-93" /isTUend="FALSE" /label="downshifts" S_feature complement(1997240..1997321) /Source="Nicolas_S_feature" /locus_tag="new_2404091_2404172_c" /HighExp="dia5, Diami, Etha, dia15, C90, Salt, LPhT, Heat, MG-0.2, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S870" promotor_-10 complement(1997314..1997333) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-10" upshifts complement(1997321) /Source="Nicolas_upshifts" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="upshifts" promotor_-35 complement(1997347..1997354) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-35" CDS complement(1997398..1998177) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 17434969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390179.1" /db_xref="EnsemblGenomes-Gn:BSU22980" /db_xref="EnsemblGenomes-Tr:CAB14214" /db_xref="GOA:P50733" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11433" /db_xref="UniProtKB/Swiss-Prot:P50733" /translation="MKLSVKIAGVLTVAAAAMTAKMYATAKGNHLKTHTFPLSKMKGK PPLTIFFISDIHKRLIDQDLLEKARSHAPHLVIIGGDLAEGGVPSARIEENIKRLVHF GVPIVFVWGNNDYEVRQHKLYSIFKAHGVITLRNESVPFSYNGHTIAIAGVDDIRMEM DHYEEAIKELDESQLNILVCHNPEIHEQINEDDGIDVILSGHTHGGQIRFGKFGPYEL GKTGIVKNAAYLISNGYGTTKVPLRLGAEPETHIVTLCGPE*" /label="ypbG CDS" gene complement(1997398..1998177) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /label="ypbG gene" promotor_-10 complement(1998203..1998218) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-10" upshifts complement(1998214) /Source="Nicolas_upshifts" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="upshifts" promotor_-35 complement(1998230..1998239) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-35" CDS complement(1998263..1998706) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390180.1" /db_xref="EnsemblGenomes-Gn:BSU22990" /db_xref="EnsemblGenomes-Tr:CAB14215" /db_xref="GOA:P50732" /db_xref="InterPro:IPR020210" /db_xref="SubtiList:BG11432" /db_xref="UniProtKB/Swiss-Prot:P50732" /translation="MESLWNQLDQFTDAPTKQMLQALVKRKQKFENYAAQCRRWRWAS LICLGLLCVMIMIKSPEPQLILQEILSHTFYLFWMLATAFAYCTSYYFKKKEEKSETD FHKLRCEIIQKSTDLWPQPDKWKARESVFHMMKHKYDINLYFESK*" /label="ypbF CDS" gene complement(1998263..1998706) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /label="ypbF gene" downshifts complement(1998280) /Source="Nicolas_upshifts" /id="D1203" /incds=0 /nref=4 /ntot=112 /MaxReadThrough="4.67294" /MaxDrop="3.33254" /score="6.86206051" /energy="-7.5" /TU="U1801" /idTUdmin="U1799" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1998769..1999491) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855244, 22950025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme possibly involved in cell wall turnover" /protein_id="NP_390181.1" /db_xref="EnsemblGenomes-Gn:BSU23000" /db_xref="EnsemblGenomes-Tr:CAB14216" /db_xref="GOA:P50731" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11431" /db_xref="UniProtKB/Swiss-Prot:P50731" /translation="MTNMSRVERRKAQNLYEDQNAALADDYVDDGESLPTRQSVKNQR EQKKKQGKTKTPLFTVLAVIFVFVPVIVLVTLFYLKSHPDNHDDYEDVFIDSSQSKYE VVPKSEDKNDTADTKETALQKESKKEPEDSKPKEQTAADKKQTAVAEKEDSPNKEEAT AAAASSSQSTVQQQEQPAEPVQNVPNRVVKHTVQKKETLYRISMKYYKSRTGEEKIRA YNHLNGNDVYTGQVLDIPLMDE*" /label="ypbE CDS" gene complement(1998769..1999491) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /label="ypbE gene" downshifts complement(1999050) /Source="Nicolas_upshifts" /id="D1204" /incds=1 /nref=4 /ntot=93 /MaxReadThrough="4.30678" /MaxDrop="3.33147" /score="6.86206051" /energy="-7.5" /TU="U1799,U1801" /idTUdmin="U1799" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" CDS complement(1999442..2000011) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390182.1" /db_xref="EnsemblGenomes-Gn:BSU23010" /db_xref="EnsemblGenomes-Tr:CAB14217" /db_xref="GOA:P50730" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG11430" /db_xref="UniProtKB/Swiss-Prot:P50730" /translation="MTQLLIIFAAAAAGLFFFEDVRDVLKLWDIRDMRIIWYGVSIAV IVILADMAVMKWFPSHLYDDGGINKKIFSKRSIPHIIFLTLLIAFAEEMLFRGVLQTH IGLWTASLIFAALHFRYLSKWLLFIMVTAISFLLGLMYEWTGNLFVPMTAHFIIDAVF ACQIRFEHVRRDKHDEHVESREKKSPESL*" /label="ypbD CDS" gene complement(1999442..2000011) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /label="ypbD gene" promotor_-10 complement(1999760..1999778) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1999776) /Source="Nicolas_upshifts" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1999793..1999799) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2000030..2000776 /Source="Nicolas_S_feature" /locus_tag="new_2406881_2407627" /HighExp="S6, S8, S7, C30, BT, S5, C90, Pyr, BC, Sw" /AntisenseName="recQ" /AntisenseCor="-0.47918253719211501" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S871" CDS complement(2000071..2001561) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16385024, 25246477, 26001966, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385024, 25246477, 26001966, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_390183.1" /db_xref="EnsemblGenomes-Gn:BSU23020" /db_xref="EnsemblGenomes-Tr:CAB14218" /db_xref="GOA:P50729" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002464" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11407" /db_xref="UniProtKB/Swiss-Prot:P50729" /translation="MTKLQQTLYQFFGFTSFKKGQQDIIESILSGKDTIAMLPTGGGK SLCYQLPGYMLDGMVLIVSPLLSLMEDQVQQLKARGEKRAAALNSMLNRQERQFVLEH IHRYKFLYLSPEALQSPYVLEKLKSVPISLFVIDEAHCISEWGHDFRPDYSKLGQLRK KLGHPPVLALTATATKETLQDVMNLLELQHAVRHLNSVNRPNIALRVENAADTAEKID RVIQLVENLQGPGIVYCPTRKWAKELAGEIKSKTSSRADFYHGGLESGDRILIQQQFI HNQLDVICCTNAFGMGVDKPDIRYVIHFHLPQTAEAFMQEIGRAGRDGKPSVSILLRA PGDFELQEQIIQMESVTAEEIADVIRVLEKTEERDERRLRDVLLQYGVGETQARMMIH LFMQGKTSVELMKKEISYRMELKLEKMHRVSFLLQRDGCLRQALLTYFDESYEPDDGN LPCCSHCGFDLSLYEQKGERSKMAPLDSWSSELHRIFSLQTVGELN*" /label="recS CDS" gene complement(2000071..2001561) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /label="recS gene" CDS complement(2001554..2002612) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /experiment="publication(s) with functional evidences, PMID:21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21170359; Product type f: factor" /codon_start=1 /transl_table=11 /product="subunit of the platform for genome maintenance machinery" /protein_id="NP_390184.1" /db_xref="EnsemblGenomes-Gn:BSU23030" /db_xref="EnsemblGenomes-Tr:CAB14219" /db_xref="InterPro:IPR008308" /db_xref="InterPro:IPR029491" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11429" /db_xref="UniProtKB/Swiss-Prot:P50728" /translation="MSLNYFDIMVLDCLCKINGERSGSAVFHLFKGKRSSQTIQDAGL FQTAKYFGMAAKCSRSDISASLDKLEKHSYLAPMSESDTYKVTASGAAVLRHALSERP WPVHCHGAHYQQAAGVLWKRLSLLVQVLSHKQQGSRQYIPVTKDHKTLHWVKKYLSRH TDHIEMAKSLFAMLEAHLKKIENKAAQIFVYSLTSHHRIGYTSRQLADTLKEDEWYVY IMFWASVHYFIHSLPECEDALLKDLLSDVHLDNALTESTRKTWQMVKQGFPIQRIAEI RKLKTATIEDHIVEISLHEPAFMINDYVSAEDQLQIAEFAKRMRTNKIKQIRDGLEQR FSYFQIRLALTKQVQQYD*" /label="gmmB CDS" gene complement(2001554..2002612) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /label="gmmB gene" promotor_-35 2001902..2001911 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2001922..2002712 /Source="Nicolas_S_feature" /locus_tag="new_2408773_2409563" /HighExp="S8, S6, S7, S5, BT, B36, Pyr, G/S, B60, nit" /AntisenseName="ypbB" /AntisenseCor="-0.76734368116597995" /AntisenseRegPval="-52.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S872" upshifts 2001922 /Source="Nicolas_upshifts" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2001924..2001943 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2002653..2002672) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2002676) /Source="Nicolas_upshifts" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2002684..2002691) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2002690..2002696 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-35" promotor_-10 2002710..2002729 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-10" S_feature 2002714..2002783 /Source="Nicolas_S_feature" /locus_tag="new_2409565_2409634" /HighExp="S6, S8, S7, S5, BT, B36, C30, Pyr, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="0.991, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S873" upshifts 2002714 /Source="Nicolas_upshifts" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="upshifts" promotor_-35 2002763..2002770 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2002785..2002877 /Source="Nicolas_S_feature" /locus_tag="new_2409636_2409728" /HighExp="LPhT, LBGstat, HPh, C90, LBGtran, C30, Lbtran, Cold, LPh, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.996" /TUlongSig="SigB" /TUlongPSig="0.991" /label="S874" promotor_-10 2002785..2002804 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2002785 /Source="Nicolas_upshifts" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="upshifts" CDS 2002878..2003126 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12538057, 21665975" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12538057, 21665975; Product type c: carrier" /codon_start=1 /transl_table=11 /product="ferredoxin" /protein_id="NP_390185.1" /db_xref="EnsemblGenomes-Gn:BSU23040" /db_xref="EnsemblGenomes-Tr:CAB14220" /db_xref="GOA:P50727" /db_xref="InterPro:IPR001080" /db_xref="InterPro:IPR017896" /db_xref="SubtiList:BG11388" /db_xref="UniProtKB/Swiss-Prot:P50727" /translation="MAKYTIVDKDTCIACGACGAAAPDIYDYDDEGIAFVTLDENKGV VEVPEVLEEDMIDAFEGCPTDSIKVADEPFEGDPLKFE*" /label="fer CDS" gene 2002878..2003126 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /label="fer gene" downshifts 2003110 /Source="Nicolas_upshifts" /id="D1205" /incds=0 /nref=221 /ntot=291 /MaxReadThrough="3.16016" /MaxDrop="8.38074" /score="34.9672707" /energy="-9.9" /TU="U1803" /idTUdmin="U1800" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2003166..2003738) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12456892, 15849754, 16850406, 17693491, 25438558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15849754, 16850406, 17693491, 25438558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="FMN permease" /protein_id="NP_390186.1" /db_xref="EnsemblGenomes-Gn:BSU23050" /db_xref="EnsemblGenomes-Tr:CAB14237" /db_xref="GOA:P50726" /db_xref="InterPro:IPR024529" /db_xref="InterPro:IPR025720" /db_xref="SubtiList:BG11428" /db_xref="UniProtKB/Swiss-Prot:P50726" /translation="MKVKKLVVVSMLSSIAFVLMLLNFPFPGLPDYLKIDFSDVPAII AILIYGPLAGIAVEAIKNVLQYIIQGSMAGVPVGQVANFIAGTLFILPTAFLFKKLNS AKGLAVSLLLGTAAMTILMSILNYVLILPAYTWFLHSPALSDSALKTAVVAGILPFNM IKGIVITVVFSLIFIKLKPWIEQQRSAHIH*" /label="fmnP CDS" gene complement(2003166..2003738) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /label="fmnP gene" downshifts complement(2003186) /Source="Nicolas_upshifts" /id="D1206" /incds=0 /nref=103 /ntot=231 /MaxReadThrough="2.60651" /MaxDrop="4.95518" /score="35.0684207" /energy="-9.9" /TU="NA" /idTUdmin="U1804" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(2003730..2004037) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /product="flavin mononucleotide riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508; Product type n: RNA" /label="fswB RNA" gene complement(2003730..2004037) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /label="fswB gene" S_feature complement(2003739..2003843) /Source="Nicolas_S_feature" /locus_tag="new_2410590_2410694_c" /HighExp="S1, LPhT, M9-stat, B60, Heat, T0.30H, Gly, S5, BC, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S875" promotor_-10 complement(2004036..2004055) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2004052) /Source="Nicolas_upshifts" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2004069..2004075) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2004164..2004171 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2004182 /Source="Nicolas_upshifts" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2004186..2004205 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2004235..2005812 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /EC_number="1.1.1.95" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoglycerate dehydrogenase" /protein_id="NP_390188.2" /db_xref="EnsemblGenomes-Gn:BSU23070" /db_xref="EnsemblGenomes-Tr:CAB14239" /db_xref="GOA:P35136" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR006236" /db_xref="InterPro:IPR029009" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10509" /db_xref="UniProtKB/Swiss-Prot:P35136" /translation="MFRVLVSDKMSNDGLQPLIESDFIEIVQKNVADAEDELHTFDAL LVRSATKVTEDLFNKMTSLKIVGRAGVGVDNIDIDEATKHGVIVINAPNGNTISTAEH TFAMISSLMRHIPQANISVKSREWNRTAYVGSELYGKTLGIVGLGRIGSEIAQRARAF GMTVHVFDPFLTEERAKKIGVNSRTFEEVLESADIITVHTPLTKETKGLLNKETIAKT KKGVRLINCARGGIIDEAALLEALENGHVAGAALDVFEVEPPVDNKLVDHPLVIATPH LGASTKEAQLNVAAQVSEEVLQFAKGLPVMSAINLPAMTKDEFAKIKPYHQIAGKIGS LVSQCMKEPVQDVAIQYEGTIAKLETSFITKALLSGFLKPRVDSTVNEVNAGGVAKER GISFSEKISSSESGYDNCISVKVTGDRSTFTVTATYIPHFGERIVEINGFNIDFYPTG HLVYIQHQDTTGVIGRVGRILGDNDINIATMQVGRKEKGGEAIMMLSFDRHLEDKIVK ELTNVPDIVSVKLIDLP*" /label="serA CDS" gene 2004235..2005812 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /label="serA gene" downshifts 2005794 /Source="Nicolas_upshifts" /id="D1207" /incds=0 /nref=246 /ntot=311 /MaxReadThrough="3.23011" /MaxDrop="8.29454" /score="32.0086708" /energy="-10.2" /TU="U1805" /idTUdmin="U1805" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS complement(2005855..2006622) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6442253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6442253; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase" /protein_id="NP_390189.1" /db_xref="EnsemblGenomes-Gn:BSU23080" /db_xref="EnsemblGenomes-Tr:CAB14240" /db_xref="GOA:P35146" /db_xref="InterPro:IPR001381" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018508" /db_xref="SubtiList:BG10538" /db_xref="UniProtKB/Swiss-Prot:P35146" /translation="MNVLTIKGVSIGEGMPKIIIPLMGKTEKQILNEAEAVKLLNPDI VEWRVDVFEKANDREAVTKLISKLRKSLEDKLFLFTFRTHKEGGSMEMDESSYLALLE SAIQTKDIDLIDIELFSGDANVKALVSLAEENNVYVVMSNHDFEKTPVKDEIISRLRK MQDLGAHIPKMAVMPNDTGDLLTLLDATYTMKTIYADRPIITMSMAATGLISRLSGEV FGSACTFGAGEEASAPGQIPVSELRSVLDILHKNTRG*" /label="aroC CDS" gene complement(2005855..2006622) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /label="aroC gene" downshifts complement(2005870) /Source="Nicolas_upshifts" /id="D1208" /incds=0 /nref=152 /ntot=231 /MaxReadThrough="2.53428" /MaxDrop="5.12103" /score="24.3727755" /energy="-10.2" /TU="NA" /idTUdmin="U1806" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 2006124..2006736 /Source="Nicolas_S_feature" /locus_tag="new_2412975_2413587" /HighExp="B36, C30, LoTm, B60, C90, HiOs, BI, Sw, T1.0H, BT" /AntisenseName="aroC" /AntisenseCor="4.7354591214804703E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S876" promotor_-10 complement(2006649..2006668) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2006662) /Source="Nicolas_upshifts" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2006683..2006686) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2006696 /Source="Nicolas_upshifts" /id="D1209" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="2.02363" /MaxDrop="5.64228" /score="10.7892325" /energy="-8.5" /TU="NA" /idTUdmin="U1805" /TUdmin=704 /isTUend="FALSE" /label="downshifts" CDS complement(2006734..2007840) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9139908, 9393439, 10712692, 14762009, 16306698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139908, 9393439, 10712692, 14762009, 16306698; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma(X) activity" /protein_id="NP_390190.2" /db_xref="EnsemblGenomes-Gn:BSU23090" /db_xref="EnsemblGenomes-Tr:CAB14241" /db_xref="GOA:P35166" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10537" /db_xref="UniProtKB/Swiss-Prot:P35166" /translation="MMKSEWNEEQIKELLSQLPAVKDHRSPQDIYKRLTMAKRKNKPA VRWIGPACAAAIAVYIAFIISPHFFDQAQPQQKEASQENAVTKTETEDSPKAASSLDQ TSFVVPEKEQDNYITVAVADADTSAIIPVSIQKTNADQTIQDMLFESSELGILDHAIT IPTFIDEVEIKEKPKQKELSIRVHQPATAFSIKDDTLLKKLLKESLKWSPYEKVKFLS DQNETGVRIGSYGTFTEISIPKQSKRSYYLYQNKQGQDFLVPSNHSFDTVKEAIKEME SSSQEDTTPLIQAGAVQSVTKKQKHLYIRFSKESEVDDSIAGILMIEGLLLTAKEFGF TEVTFTETRTKKIGKYDISDAIPVPAAPNPISLN*" /label="rsiX CDS" gene complement(2006734..2007840) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /label="rsiX gene" downshifts complement(2006751) /Source="Nicolas_upshifts" /id="D1210" /incds=0 /nref=155 /ntot=242 /MaxReadThrough="3.84557" /MaxDrop="5.30684" /score="7.9467954" /energy="-6.7" /TU="U1809" /idTUdmin="U1806" /TUdmin="-881" /isTUend="FALSE" /label="downshifts" CDS complement(2007776..2008360) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9636707, 11222589, 12399481, 14762009, 19767430, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9636707, 11222589, 12399481, 14762009, 19767430, 27965645; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor sigma(X)" /protein_id="NP_390191.2" /db_xref="EnsemblGenomes-Gn:BSU23100" /db_xref="EnsemblGenomes-Tr:CAB14242" /db_xref="GOA:P35165" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10536" /db_xref="UniProtKB/Swiss-Prot:P35165" /translation="MEETFQLLYDTYHQDLYQFLFYMVKDKNQTEDLLQEVYIRVLNS YHTFEGRSSEKTWLLSIARHVAIDWFRKQQTIRQRILGTFDWDTQDVRDQQLLPDELA VQHENVREIYAALDQCTIDQRAVIILRFIQGYSIQETAKALRFSESKVKTTQHRGLKV LRKHMELLREELMDDEVRMERRTDKGVVKSTSGS*" /label="sigX CDS" gene complement(2007776..2008360) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /label="sigX gene" promotor_-35 2008154..2008159 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2008170 /Source="Nicolas_upshifts" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2008174..2008178 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2008311..2008316 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2008328 /Source="Nicolas_upshifts" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2008332..2008350 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2008368 /Source="Nicolas_upshifts" /id="D1211" /incds=0 /nref=8 /ntot=81 /MaxReadThrough="5.89234" /MaxDrop="4.38483" /score="6.57298987" /energy="-13.5" /TU="U1808" /idTUdmin="U1807" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2008409..2008428) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2008413..2008520 /Source="Nicolas_S_feature" /locus_tag="new_2415264_2415371" /HighExp="S4, S8, S6, S7, C30, S3, LoTm, B60, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S877" upshifts complement(2008417) /Source="Nicolas_upshifts" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2008441..2008448) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2008476 /Source="Nicolas_upshifts" /id="D1212" /incds=0 /nref=12 /ntot=64 /MaxReadThrough="2.08559" /MaxDrop="4.36303" /score="6.57298987" /energy="-13.5" /TU="NA" /idTUdmin="U1808" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(2008505..2008563) /Source="Nicolas_S_feature" /locus_tag="new_2415356_2415414_c" /HighExp="Lbstat, BI, nit, S0, M40t90, Lbtran, M0t90, G135, Sw, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S878" downshifts complement(2008536) /Source="Nicolas_upshifts" /id="D1213" /incds=0 /nref=156 /ntot=252 /MaxReadThrough="2.62215" /MaxDrop="6.99198" /score="33.3049318" /energy="-13.5" /TU="NA" /idTUdmin="U1810" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2008564..2010333) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase (ResD / ResE)" /protein_id="NP_390192.1" /db_xref="EnsemblGenomes-Gn:BSU23110" /db_xref="EnsemblGenomes-Tr:CAB14243" /db_xref="GOA:P35164" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4ZR7" /db_xref="SubtiList:BG10535" /db_xref="UniProtKB/Swiss-Prot:P35164" /translation="MKFWKSVVGKLWFTILSLVLIVLFILTVLLLEFIENYHVEEAEN DLTQLANKVAVILENHEDQALARSITWELADNLTSIAIIQDEKNHWYSPNDKNRLSSI TVEQIQHDKDLNKALKDHKKVSKRTGLSDTDTDNERLIVGVPYEKDGKKGMVFLSQSL LAVKDTTKHTTRYIFLAAGIAIVLTTFFAFFLSSRVTYPLRKMREGAQDLAKGKFDTK IPILTQDEIGELATAFNQMGRQLNFHINALNQEKEQLSNILSSMADGVITINIDGTIL VTNPPAERFLQAWYYEQNMNIKEGDNLPPEAKELFQNAVSTEKEQMIEMTLQGRSWVL LMSPLYAESHVRGAVAVLRDMTEERRLDKLREDFIANVSHELRTPISMLQGYSEAIVD DIASSEEDRKEIAQIIYDESLRMGRLVNDLLDLARMESGHTGLHYEKINVNEFLEKII RKFSGVAKEKNIALDHDISLTEEEFMFDEDKMEQVFTNLIDNALRHTSAGGSVSISVH SVKDGLKIDIKDSGSGIPEEDLPFIFERFYKADKARTRGRAGTGLGLAIVKNIVEAHN GSITVHSRIDKGTTFSFYIPTKR*" /label="resE CDS" gene complement(2008564..2010333) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /label="resE gene" downshifts complement(2008620) /Source="Nicolas_upshifts" /id="D1214" /incds=0 /nref=5 /ntot=13 /MaxReadThrough="7.56028" /MaxDrop="3.58685" /score="33.3049318" /energy="-13.5" /TU="U1810,U1811,U1812" /idTUdmin="U1810" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2010330..2011052) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator (ResD / ResE)" /protein_id="NP_390193.2" /db_xref="EnsemblGenomes-Gn:BSU23120" /db_xref="EnsemblGenomes-Tr:CAB14244" /db_xref="GOA:P35163" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10534" /db_xref="UniProtKB/Swiss-Prot:P35163" /translation="MDQTNETKILVVDDEARIRRLLRMYLERENYAIDEAENGDEAIA KGLEANYDLILLDLMMPGTDGIEVCRQIREKKATPIIMLTAKGEEANRVQGFEAGTDD YIVKPFSPREVVLRVKALLRRASQTSYFNANTPTKNVLVFSHLSIDHDAHRVTADGTE VSLTPKEYELLYFLAKTPDKVYDREKLLKEVWQYEFFGDLRTVDTHVKRLREKLNKVS PEAAKKIVTVWGVGYKFEVGAE*" /label="resD CDS" gene complement(2010330..2011052) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /label="resD gene" S_feature complement(2011053..2011132) /Source="Nicolas_S_feature" /locus_tag="new_2417904_2417983_c" /HighExp="Lbstat, M0t90, ferm, M40t90, S2, S0, nit, M40t45, BI, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S879" CDS complement(2011133..2012308) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10844653, 12682299, 15849754, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844653, 12682299, 15849754, 16850406, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390194.2" /db_xref="EnsemblGenomes-Gn:BSU23130" /db_xref="EnsemblGenomes-Tr:CAB14245" /db_xref="GOA:P35162" /db_xref="InterPro:IPR002541" /db_xref="InterPro:IPR017562" /db_xref="SubtiList:BG10533" /db_xref="UniProtKB/Swiss-Prot:P35162" /translation="MAELSGNFLYAAFLVYLIAVPIFGGAIRGNKDKKGRPNRWANIG ITLSIVGFFCHLGYFITRWAASGHAPVSNMFEFTTAFGMMLVLAFIILYFLYRLPSLG LFTLSIALLLIAYASMFPTDISPLIPSLQSNWLYIHVTTAALGQAILAISFVAGVIFL LKHVDQTKPSKKTFWLEAIMFILVTTVAFIAITSAFRLAGYEAEFNWVDKSKEKSVMV YEMPALVGPHQGELLTEGRMEPLVDLPALFSGRKVNTVIWSFGAGLVLYGALRLIIRK RISALLHPLVKNVNLDLVDEVGYRAVSIGFPIFTLGALIFAMIWAQLAWTRFWGWDPK EVWALITFLFYAAYLHLRLSRGWHGEKSAWLAVIGFAIIMFNLIFVNLVLAGLHSYA* " /label="resC CDS" gene complement(2011133..2012308) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /label="resC gene" CDS complement(2012328..2013956) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9395519, 10844653, 12682299, 16825793, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9395519, 10844653, 12682299, 16825793, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390195.1" /db_xref="EnsemblGenomes-Gn:BSU23140" /db_xref="EnsemblGenomes-Tr:CAB14246" /db_xref="GOA:P35161" /db_xref="InterPro:IPR007816" /db_xref="SubtiList:BG10532" /db_xref="UniProtKB/Swiss-Prot:P35161" /translation="MKQVKCECGHINPVGTVLCESCGRALQETQPPLADMRYDGSARR SQTYNKTIIDKIWNFFSSVKVGIWLIVITLAASAFGTIFPQEAYLPPGAQADTYYKEQ YGTFGQLYYLLGFHHLYGSWWYLLLIASIGISLVICSLDRVIPLYRALKNQGVRRSPA FLRRQRLFSETVTVLNGESKEKIVTLLKKKHYRIREKEGSILAEKGRFSRWGPYVNHI GLIIFLIGAMLRFVPGMYVDETLWVREGETAAIPGTDGKYYLKNNQFSVETYNSKTEK KVFADAIDRVGDGRVAKNFQTDAVLYKREGKIVYGEKPKLEKVTEEDIRVNQPLRFDS FSVYQVDYKENQLDQMVFQLIDKKTKKSFGSLKINLLDPDSVYDLGNGYKVEIASYLP DFYFNQDGEPSTKTKIPNNPAFVFNIITPDKPKGEKSFVAIQETIEGSGNNKYKLKFD HVETKNITGLTVRKDLTLWVLAVGGAIFMIGVIQGMYWQHRRIWLHSQDGAVMVAGHT NKNWFGLKKDLAFILADSGLTEPVDQKELIKTQK*" /label="resB CDS" gene complement(2012328..2013956) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /label="resB gene" CDS complement(2013953..2014492) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracytoplasmic thioredoxin involved in cytochrome c maturation (lipoprotein)" /protein_id="NP_390196.2" /db_xref="EnsemblGenomes-Gn:BSU23150" /db_xref="EnsemblGenomes-Tr:CAB14247" /db_xref="GOA:P35160" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR023555" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ST9" /db_xref="PDB:1SU9" /db_xref="PDB:2F9S" /db_xref="PDB:2H19" /db_xref="PDB:2H1A" /db_xref="PDB:2H1B" /db_xref="PDB:2H1D" /db_xref="PDB:2H1G" /db_xref="PDB:3C71" /db_xref="PDB:3C73" /db_xref="SubtiList:BG10531" /db_xref="UniProtKB/Swiss-Prot:P35160" /translation="MKKKRRLFIRTGILLVLICALGYTIYNAVFAGKESISEGSDAPN FVLEDTNGKRIELSDLKGKGVFLNFWGTWCEPCKKEFPYMANQYKHFKSQGVEIVAVN VGESKIAVHNFMKSYGVNFPVVLDTDRQVLDAYDVSPLPTTFLINPEGKVVKVVTGTM TESMIHDYMNLIKPGETSG*" /label="resA CDS" gene complement(2013953..2014492) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /label="resA gene" S_feature complement(2014493..2014586) /Source="Nicolas_S_feature" /locus_tag="new_2421344_2421437_c" /HighExp="LBGtran, LBGstat, G180, Oxctl, H2O2, G150, M0t90, G135, Paraq, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S880" CDS complement(2014587..2015321) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /EC_number="4.2.1.70" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9888802, 24214967" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888802, 24214967; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA pseudouridine 2633 (=2605 standard) pseudouridine synthase" /protein_id="NP_390197.2" /db_xref="EnsemblGenomes-Gn:BSU23160" /db_xref="EnsemblGenomes-Tr:CAB14248" /db_xref="GOA:P35159" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10530" /db_xref="UniProtKB/Swiss-Prot:P35159" /translation="MERLQKVIAHAGVASRRKAEELIKEGKVKVNGKVVTELGVKVTG SDQIEVNGLKVEREEPVYFLLYKPRGVISAAQDDKGRKVVTDFFKNIPQRIYPIGRLD YDTSGLLLLTNDGEFANKLMHPKYEIDKTYVAKVKGIPPKELLRKLERGIRLEEGKTA PAKAKLLSLDKKKQTSIIQLTIHEGRNRQVRRMFEAIGHEVIKLKREEYAFLNLRGLH TGDARELTPHEVKRLRALADHGKNAF*" /label="rluB CDS" gene complement(2014587..2015321) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /label="rluB gene" promotor_-10 complement(2015330..2015349) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2015353) /Source="Nicolas_upshifts" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2015364..2015368) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2015413..2015949) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390198.2" /db_xref="EnsemblGenomes-Gn:BSU23170" /db_xref="EnsemblGenomes-Tr:CAB14249" /db_xref="GOA:P35158" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10529" /db_xref="UniProtKB/Swiss-Prot:P35158" /translation="MEIINWLSLAMIPIIIAGILLYGTIKKVPTYESFVEGGKEGIEI AFSIIPYLVGMLVAITVFRSSGALDFIMDLLKPAFSAIGIPAEVVPLALIRPISGTAA LGMTTDLIAVYGPDSFIGRLASVMQGSTDTTLYVLTVYFGAVGIKKMGDALKVGLLAD LIGVVASIIIVTLLFGSA*" /label="spmB CDS" gene complement(2015413..2015949) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /label="spmB gene" promotor_-10 complement(2015418..2015437) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2015422) /Source="Nicolas_upshifts" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2015452..2015459) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2015954..2016544) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390199.1" /db_xref="EnsemblGenomes-Gn:BSU23180" /db_xref="EnsemblGenomes-Tr:CAB14250" /db_xref="GOA:P35157" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10528" /db_xref="UniProtKB/Swiss-Prot:P35157" /translation="MVNIIWVSLTVIGLVFAMCNGTLQDVNEAVFKGAKEAITISFGL MSVLVFWLGLMKIAEQSGLLDIFSRMCRPFISKLFPDIPPDHPAMGYILSNLMANFFG LGNAATPLGIKAMEQMKKLNGNRSEASRSMITFLAVNTSCITLIPTTVIAVRMAYSSK TPTDIVGPSILATLISGIGAIIIDRYFYYRRKKKGR*" /label="spmA CDS" gene complement(2015954..2016544) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /label="spmA gene" CDS complement(2016532..2017680) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /EC_number="3.4.16.4" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 8892816, 9864321, 10498740, 18266856, 19542328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 8892816, 9864321, 10498740, 18266856, 19542328; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5*) (required for spore cortex)" /protein_id="NP_390200.1" /db_xref="EnsemblGenomes-Gn:BSU23190" /db_xref="EnsemblGenomes-Tr:CAB14251" /db_xref="GOA:P35150" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR018044" /db_xref="PDB:3MFD" /db_xref="SubtiList:BG10527" /db_xref="UniProtKB/Swiss-Prot:P35150" /translation="MRIFKKAVFVIMISFLIATVNVNTAHAAIDVSAKSAIIIDGASG RVLYAKDEHQKRRIASITKIMTAVLAIESGKMDQTVTVSANAVRTEGSAIYLTEGQKV KLKDLVYGLMLRSGNDAAVAIAEHVGGSLDGFVYMMNQKAEQLGMKNTRFQNPHGLDD HENHYSTAYDMAILTKYAMKLKDYQKISGTKIYKAETMESVWKNKNKLLTMLYPYSTG GKTGYTKLAKRTLVSTASKDGIDLIAVTINDPNDWDDHMKMFNYVFEHYQTYLIAKKG DIPKLKGTFYESKAFIKRDITYLLTEEEKENVKINTTLLKPKKAWEKDASKIPDIVGH MEIMFNDATIAKVPIYYENERHQKPKKQFFETFKSIFLNAAGGAKWSI*" /label="dacB CDS" gene complement(2016532..2017680) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /label="dacB gene" promotor_-10 complement(2017702..2017720) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2017709) /Source="Nicolas_upshifts" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2017735..2017740) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2017803..2018342) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12065423" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390201.1" /db_xref="EnsemblGenomes-Gn:BSU23200" /db_xref="EnsemblGenomes-Tr:CAB14252" /db_xref="InterPro:IPR025013" /db_xref="SubtiList:BG10526" /db_xref="UniProtKB/Swiss-Prot:P35156" /translation="MKEAKCERQIHEGKIPNEMGHSIVRAQTQKTGEFLSMVVNTVND YLNQTTLESLQAELPIEKGYCCDVLSTLRRMAVFCEGGAEACRRLLMQEPFQEARAEK TLYNVYHQCIEEFFMPKKDTWCENSRASYTGVSAIEFYHAVPASLEQLLLPLSAAFLK MREELAHYEASGSSMAPIR*" /label="ypuI CDS" gene complement(2017803..2018342) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /label="ypuI gene" downshifts complement(2017816) /Source="Nicolas_upshifts" /id="D1215" /incds=0 /nref=219 /ntot=260 /MaxReadThrough="1.63638" /MaxDrop="8.00748" /score="36.7302977" /energy="-12.2" /TU="NA" /idTUdmin="U1813" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2018351..2018368) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2018366) /Source="Nicolas_upshifts" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2018383..2018388) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2018397..2018990) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation factor" /protein_id="NP_390202.1" /db_xref="EnsemblGenomes-Gn:BSU23210" /db_xref="EnsemblGenomes-Tr:CAB14253" /db_xref="GOA:P35155" /db_xref="InterPro:IPR005234" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10525" /db_xref="UniProtKB/Swiss-Prot:P35155" /translation="MGLDIVNWKAIVEALLYAAGDEGLTKKQLLTVLEIEEPELNTIM ADVADEYRGDTRGIELIEYADTYMLSTKKDFAPYLKKLIEVPSKGLSQASLEVLAIVS YKQPITRAEIEEIRGVKSERILHSLVAKALLCEVGRADGPGRAILYGTTPTFLEQFGL KTLDELPPLPENAEEDVLQEEADLFFENFNQTFEDIK*" /label="spcB CDS" gene complement(2018397..2018990) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /label="spcB gene" CDS complement(2018980..2019735) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and partitioning factor" /protein_id="NP_390203.1" /db_xref="EnsemblGenomes-Gn:BSU23220" /db_xref="EnsemblGenomes-Tr:CAB14254" /db_xref="GOA:P35154" /db_xref="InterPro:IPR003768" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG10524" /db_xref="UniProtKB/Swiss-Prot:P35154" /translation="MEEYQVKIDTFEGPLDLLLHLINRLEIDIYDIPVAKITEQYLLY VHTMRVLELDIASEYLVMAATLLSIKSRMLLPKQEEELFEDELLEEEDPREELIEKLI EYRKYKDAAKDLKEREEERQKSFTKPPSDLSEYAKEVKQSEQKLSVTVYDMIGAFQKV LKRKKINRPMETTITRQDIPIEARMNEIVHSLKSRGTRINFMDLFPYEQKEHLVVTFL AVLELMKNQLVLIEQEHNFSDIYITGSESIHGA*" /label="scpA CDS" gene complement(2018980..2019735) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /label="scpA gene" promotor_-35 2019579..2019588 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2019601..2019620 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2019610 /Source="Nicolas_upshifts" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2019781..2019800) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2019796) /Source="Nicolas_upshifts" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2019814..2019821) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2019961..2019968 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2019979..2019998 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2019984 /Source="Nicolas_upshifts" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="upshifts" CDS 2020016..2020540 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390204.1" /db_xref="EnsemblGenomes-Gn:BSU23230" /db_xref="EnsemblGenomes-Tr:CAB14255" /db_xref="InterPro:IPR005500" /db_xref="InterPro:IPR023203" /db_xref="SubtiList:BG10523" /db_xref="UniProtKB/Swiss-Prot:P17617" /translation="MYPKAYIDYLVEFHATRDYFECHEILEEYWKEDPPKKRKRYWVG FIQLAVALYHHRRQNTAGAKRLMANSIRILQAEHRAVEDLGLDHGRLLELMQSVYEQI ETVSAYKSIILPIKDEKLEEACRIECRKKKYTWGQPSALSNIFLIDKHRLRDRTDVIR EREKEIERRKKSRD*" /label="ypuF CDS" gene 2020016..2020540 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /label="ypuF gene" CDS complement(2020554..2020928) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15466513, 25349719; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative riboflavin synthesis-related N-acetyltransferase" /protein_id="NP_390205.1" /db_xref="EnsemblGenomes-Gn:BSU23240" /db_xref="EnsemblGenomes-Tr:CAB14256" /db_xref="GOA:P17622" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10522" /db_xref="UniProtKB/Swiss-Prot:P17622" /translation="MLIRYKKSFEKIAMGLLSFMPNEKDLKQLQQTIKDYETDTDRQL FLWKEDEDIVGAIGVEKKDSEVEIRHISVNPSHRHQGIGKQMMDALKHLFKTQVLVPN ELTQSFFERCQGQQDQDISYNN*" /label="ypzK CDS" gene complement(2020554..2020928) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /label="ypzK gene" downshifts complement(2020570) /Source="Nicolas_upshifts" /id="D1216" /incds=0 /nref=264 /ntot=275 /MaxReadThrough="1.34496" /MaxDrop="8.09525" /score="39.5464967" /energy="-14.3" /TU="NA" /idTUdmin="U1817" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2020990..2021009) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2021002) /Source="Nicolas_upshifts" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2021021..2021028) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2021041..2021505) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /EC_number="2.5.1.78" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3100522, 7473709, 10881048, 12456892, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3100522, 7473709, 10881048, 12456892, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6,7-dimethyl-8-ribityllumazine synthase, beta subunit" /protein_id="NP_390206.1" /db_xref="EnsemblGenomes-Gn:BSU23250" /db_xref="EnsemblGenomes-Tr:CAB14257" /db_xref="GOA:P11998" /db_xref="InterPro:IPR002180" /db_xref="InterPro:IPR034964" /db_xref="InterPro:IPR036467" /db_xref="PDB:1RVV" /db_xref="PDB:1ZIS" /db_xref="SubtiList:BG10521" /db_xref="UniProtKB/Swiss-Prot:P11998" /translation="MNIIQGNLVGTGLKIGIVVGRFNDFITSKLLSGAEDALLRHGVD TNDIDVAWVPGAFEIPFAAKKMAETKKYDAIITLGTVIRGATTHYDYVCNEAAKGIAQ AANTTGVPVIFGIVTTENIEQAIERAGTKAGNKGVDCAVSAIEMANLNRSFE*" /label="ribH CDS" gene complement(2021041..2021505) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /label="ribH gene" promotor_-35 2021376..2021380 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2021394..2021398 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2021397 /Source="Nicolas_upshifts" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2021538..2022734) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /EC_number="3.5.4.25" /EC_number="4.1.99.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9297088, 9515916, 12456892, 19583770, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9297088, 9515916, 12456892, 19583770, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused 3,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II" /protein_id="NP_390207.1" /db_xref="EnsemblGenomes-Gn:BSU23260" /db_xref="EnsemblGenomes-Tr:CAB14258" /db_xref="GOA:P17620" /db_xref="InterPro:IPR000422" /db_xref="InterPro:IPR000926" /db_xref="InterPro:IPR016299" /db_xref="InterPro:IPR017945" /db_xref="InterPro:IPR032677" /db_xref="InterPro:IPR036144" /db_xref="SubtiList:BG10520" /db_xref="UniProtKB/Swiss-Prot:P17620" /translation="MFHPIEEALDALKKGEVIIVVDDEDRENEGDFVALAEHATPEVI NFMATHGRGLICTPLSEEIADRLDLHPMVEHNTDSHHTAFTVSIDHRETKTGISAQER SFTVQALLDSKSVPSDFQRPGHIFPLIAKKGGVLKRAGHTEAAVDLAEACGSPGAGVI CEIMNEDGTMARVPELIEIAKKHQLKMITIKDLIQYRYNLTTLVEREVDITLPTDFGT FKVYGYTNEVDGKEHVAFVMGDVPFGEEPVLVRVHSECLTGDVFGSHRCDCGPQLHAA LNQIAAEGRGVLLYLRQEGRGIGLINKLKAYKLQEQGYDTVEANEALGFLPDLRNYGI GAQILRDLGVRNMKLLTNNPRKIAGLEGYGLSISERVPLQMEAKEHNKKYLQTKMNKL GHLLHF*" /label="ribBA CDS" gene complement(2021538..2022734) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /label="ribBA gene" CDS complement(2022749..2023396) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /EC_number="2.5.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2106516, 12456892" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2106516, 12456892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="riboflavin synthase (alpha subunit)" /protein_id="NP_390208.1" /db_xref="EnsemblGenomes-Gn:BSU23270" /db_xref="EnsemblGenomes-Tr:CAB14259" /db_xref="GOA:P16440" /db_xref="InterPro:IPR001783" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR026017" /db_xref="SubtiList:BG10519" /db_xref="UniProtKB/Swiss-Prot:P16440" /translation="MFTGIIEETGTIESMKKAGHAMALTIKCSKILEDVHLGDSIAVN GICLTVTDFTKNQFTVDVMPETVKATSLNDLTKGSKVNLERAMAANGRFGGHFVSGHV DGTAEITRIEEKSNAVYYDLKMDPSLTKTLVLKGSITVDGVSLTIFGLTEDTVTISLI PHTISETIFSEKTIGSKVNIECDMIGKYMYRFLHKANENKTQQTITKAFLSENGF*" /label="ribE CDS" gene complement(2022749..2023396) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /label="ribE gene" CDS complement(2023407..2024492) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /EC_number="1.1.1.193" /EC_number="3.5.4.26" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9068650, 12456892, 17765262, 18986985, 23385458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068650, 12456892, 17765262, 18986985, 23385458; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused diaminohydroxyphosphoribosylaminopyrimidine deaminase; 5-amino-6-(5-phosphoribosylamino) uracil reductase" /protein_id="NP_390209.1" /db_xref="EnsemblGenomes-Gn:BSU23280" /db_xref="EnsemblGenomes-Tr:CAB14260" /db_xref="GOA:P17618" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR004794" /db_xref="InterPro:IPR011549" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024072" /db_xref="PDB:2B3Z" /db_xref="PDB:2D5N" /db_xref="PDB:3EX8" /db_xref="PDB:4G3M" /db_xref="SubtiList:BG10518" /db_xref="UniProtKB/Swiss-Prot:P17618" /translation="MEEYYMKLALDLAKQGEGQTESNPLVGAVVVKDGQIVGMGAHLK YGEAHAEVHAIHMAGAHAEGADIYVTLEPCSHYGKTPPCAELIINSGIKRVFVAMRDP NPLVAGRGISMMKEAGIEVREGILADQAERLNEKFLHFMRTGLPYVTLKAAASLDGKI ATSTGDSKWITSEAARQDAQQYRKTHQSILVGVGTVKADNPSLTCRLPNVTKQPVRVI LDTVLSIPEDAKVICDQIAPTWIFTTARADEEKKKRLSAFGVNIFTLETERIQIPDVL KILAEEGIMSVYVEGGSAVHGSFVKEGCFQEIIFYFAPKLIGGTHAPSLISGEGFQSM KDVPLLQFTDITQIGRDIKLTAKPTKE*" /label="ribD CDS" gene complement(2023407..2024492) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /label="ribD gene" S_feature complement(2024493..2024621) /Source="Nicolas_S_feature" /locus_tag="new_2431344_2431472_c" /HighExp="T0.30H, B60, T1.30H, T2.0H, MG-0.2, T1.0H, S1, T0.0H, LPhT, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S881" misc_RNA complement(2024622..2024766) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /product="flavin riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508, 17693491, 17997835" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508, 17693491, 17997835; Product type n: RNA" /label="fswA RNA" gene complement(2024622..2024766) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /label="fswA gene" promotor_-10 complement(2024783..2024802) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2024793) /Source="Nicolas_upshifts" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2024817..2024824) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2024886..2025230) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390211.1" /db_xref="EnsemblGenomes-Gn:BSU23300" /db_xref="EnsemblGenomes-Tr:CAB14262" /db_xref="SubtiList:BG10516" /db_xref="UniProtKB/Swiss-Prot:P17616" /translation="MGRIKTKITILLVLLLLLAGGYMYINDIELKDVPTAIGQTLSSE EEEYTIQEYKVTKIDGSEYHGVAENGTKIIFNGKKLNQDLSDIKEGDKIKAYFSKSKR IDGLIKVAKVND*" /label="ypuD CDS" gene complement(2024886..2025230) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /label="ypuD gene" downshifts complement(2024901) /Source="Nicolas_upshifts" /id="D1217" /incds=0 /nref=78 /ntot=221 /MaxReadThrough="1.58771" /MaxDrop="5.14851" /score="20.5522057" /energy="-14.7" /TU="NA" /idTUdmin="U1820" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2025262..2025280) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2025275) /Source="Nicolas_upshifts" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2025289..2025294 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2025295..2025301) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2025309..2026231 /Source="Nicolas_S_feature" /locus_tag="new_2432160_2433082" /HighExp="S5, S4, S6, S8, S7, C30, S3, C90, BT, BC" /AntisenseName="sipS" /AntisenseCor="-0.46666993867379197" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S882" upshifts 2025309 /Source="Nicolas_upshifts" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2025310..2025328 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2025316..2025331) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2025319) /Source="Nicolas_upshifts" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2025321..2025387) /Source="Nicolas_S_feature" /locus_tag="new_2432172_2432238_c" /HighExp="Etha, T1.30H, M9-stat, T0.30H, M40t90, T2.30H, MG-0.2, MG 15, HiTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S883" promotor_-35 complement(2025344..2025353) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2025382..2025390) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2025387) /Source="Nicolas_upshifts" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2025404..2025412) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2025465..2026019) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /EC_number="3.4.21.89" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_390212.1" /db_xref="EnsemblGenomes-Gn:BSU23310" /db_xref="EnsemblGenomes-Tr:CAB14263" /db_xref="GOA:P28628" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG10515" /db_xref="UniProtKB/Swiss-Prot:P28628" /translation="MKSENVSKKKSILEWAKAIVIAVVLALLIRNFIFAPYVVDGDSM YPTLHNRERVFVNMTVKYIGEFDRGDIVVLNGDDVHYVKRIIGLPGDTVEMKNDQLYI NGKKVDEPYLAANKKRAKQDGFDHLTDDFGPVKVPDNKYFVMGDNRRNSMDSRNGLGL FTKKQIAGTSKFVFYPFNEMRKTN*" /label="sipS CDS" gene complement(2025465..2026019) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /label="sipS gene" downshifts complement(2025475) /Source="Nicolas_upshifts" /id="D1218" /incds=0 /nref=195 /ntot=252 /MaxReadThrough="3.6233" /MaxDrop="7.24702" /score="30.4586783" /energy="-10.9" /TU="U1824" /idTUdmin="U1825" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2026045..2026064) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2026063) /Source="Nicolas_upshifts" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2026065..2026464) /Source="Nicolas_S_feature" /locus_tag="new_2432916_2433315_c" /HighExp="T4.0H, T2.30H, T5.0H, T3.0H, T2.0H, T3.30H, M9-stat, C90, BC, T1.30H" /AntisenseName="ypzC" /AntisenseCor="-0.215992681600812" /AntisenseRegPval="-3.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S884" promotor_-35 complement(2026076..2026082) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2026286..2026522 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390213.1" /db_xref="EnsemblGenomes-Gn:BSU23320" /db_xref="EnsemblGenomes-Tr:CAB14264" /db_xref="SubtiList:BG13765" /db_xref="UniProtKB/Swiss-Prot:O32012" /translation="MFIYCIPLISQSMIPMALDKTINVMKVTGMFAATYFTGDNRTPF FAFIICLKSFKLENMDQPPKNKSNIFPAVEDSLL*" /label="ypzC CDS" gene 2026286..2026522 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /label="ypzC gene" CDS complement(2026465..2026671) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097757.1" /db_xref="EnsemblGenomes-Gn:BSU23328" /db_xref="EnsemblGenomes-Tr:CAX52656" /db_xref="InterPro:IPR018652" /db_xref="UniProtKB/Swiss-Prot:C0H447" /translation="MNNKGCIKCGSTEAGQKEIATTGTGLSKLFDVQHNRFLVVYCKN CGYSEFYNKESSTAGNILDLFFGG*" /label="ypzJ CDS" gene complement(2026465..2026671) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /label="ypzJ gene" misc_feature complement(2026704..2026723) /Source="Nicolas_upshift_promotors" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2026726) /Source="Nicolas_upshifts" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="upshifts" CDS complement(2026780..2027034) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="PSEUDO:CAX52657.1" /translation="MSFLVFVLIFLFVILTRRVCKLLHFFVYYRFIPHRAEPCVLYEQ YPSDVAAGYAFGGVWLSLNVLVMELFRFSRRFTKLRNEPN*" /label="ypuC CDS" gene complement(2026780..2027034) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /pseudo /label="ypuC gene" promotor_-35 2026914..2026923 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2026925..2027314) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15849754, 16850406" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="SubtiList:BG10514" /translation="MSYWIGYRLGPAAIQKAFASRGVLLAVIVLTFFWTVFRGQDRKI ELSFLFFLVIGGELYEEGIRRLFHSLHPVHAPLESHVLYPFPSEQTLTAFVIFGFCAY LFVRHSHKTRLQTVAFFCLLSFYSSSG*" /label="ypuC CDS" gene complement(2026925..2027314) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /pseudo /label="ypuC gene" S_feature 2026937..2028008 /Source="Nicolas_S_feature" /locus_tag="new_2433788_2434859" /HighExp="S6, S8, S7, BT, S5, B36, S4, Pyr, G/S, C30" /AntisenseName="ypuC" /AntisenseCor="0.37168085148262697" /AntisenseRegPval="-9.5" /CDS_PredictionProba="0.69113899999999995" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S885" promotor_-10 2026937..2026956 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2026937 /Source="Nicolas_upshifts" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2027292..2027495) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390215.1" /db_xref="EnsemblGenomes-Gn:BSU23340" /db_xref="EnsemblGenomes-Tr:CAB14266" /db_xref="SubtiList:BG10513" /db_xref="UniProtKB/Swiss-Prot:P35151" /translation="MQVLTGLLEQYGYAVLFIVLMLELLALLGPGEFAGVLVFQEKLN WVLSMLAAGLGSCGSEHVVLDRV*" /label="ypuB CDS" gene complement(2027292..2027495) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /label="ypuB gene" CDS 2027904..2028020 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:SOX90572.1" /translation="MYMHFESAQDDPITFARKAAAAFRVVKRIDRYLGFRKL*" /label="hypothetical protein CDS" gene 2027904..2028020 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /pseudo /label="gene" downshifts 2027971 /Source="Nicolas_upshifts" /id="D1219" /incds=0 /nref=3 /ntot=18 /MaxReadThrough="-0.179729999999999" /MaxDrop="3.76747" /score="-7.5033349" /energy="-9.1" /TU="NA" /idTUdmin="U1826" /TUdmin=198 /isTUend="FALSE" /label="downshifts" promotor_-35 2028097..2028106 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2028119..2028138 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2028119 /Source="Nicolas_upshifts" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="upshifts" CDS 2028161..2028373 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative germination protein" /protein_id="NP_390216.1" /db_xref="EnsemblGenomes-Gn:BSU23350" /db_xref="EnsemblGenomes-Tr:CAB14267" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13766" /db_xref="UniProtKB/Swiss-Prot:O32013" /translation="MIDYPININNVSGNSVINVGGAFMIRPLTLSKSVFGSGGLNTGI VFENNFVSKAKMINHQFTDQNVTKTF*" /label="ypzD CDS" gene 2028161..2028373 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /label="ypzD gene" downshifts 2028367 /Source="Nicolas_upshifts" /id="D1220" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="4.9048" /MaxDrop="3.6863" /score="3.56038753" /energy="-6.9" /TU="U1827" /idTUdmin="U1827" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" downshifts complement(2028509) /Source="Nicolas_upshifts" /id="D1221" /incds=0 /nref=254 /ntot=263 /MaxReadThrough="2.52018" /MaxDrop="8.47213" /score="34.3429406" /energy="-12.4" /TU="NA" /idTUdmin="U1828" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2028509..2028940) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8639516, 9063446, 9748346, 25184565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8639516, 9063446, 9748346, 25184565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-prolyl isomerase" /protein_id="NP_390217.1" /db_xref="EnsemblGenomes-Gn:BSU23360" /db_xref="EnsemblGenomes-Tr:CAB14268" /db_xref="GOA:P35137" /db_xref="InterPro:IPR002130" /db_xref="InterPro:IPR020892" /db_xref="InterPro:IPR024936" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG10512" /db_xref="UniProtKB/Swiss-Prot:P35137" /translation="MKTGYFLLEDGNKIEFELYPEAAPGTVANFEKLANEGFYDGLTF HRVIPGFVSQGGCPHGTGTGGPGYTIKCETEGNPHTHEAGALSMAHAGKDTGGSQFFI VHEPQPHLNGVHTVFGKVTSGLEFAKNMSNGDVMKEVRVEG*" /label="ppiB CDS" gene complement(2028509..2028940) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /label="ppiB gene" S_feature complement(2028941..2029027) /Source="Nicolas_S_feature" /locus_tag="new_2435792_2435878_c" /HighExp="dia5, dia15, dia0, Lbexp, LBGtran, C90, Lbtran, HPh, G180, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S886" promotor_-10 complement(2029010..2029029) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2029027) /Source="Nicolas_upshifts" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2029043..2029048) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2029077..2029086 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2029096..2029193 /Source="Nicolas_S_feature" /locus_tag="new_2435947_2436044" /HighExp="Heat, Etha, Salt, dia0, HiTm, T0.30H, B60, Lbexp, T1.0H, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S887" upshifts 2029096 /Source="Nicolas_upshifts" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2029099..2029114 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2029194..2030066 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17434969, 18179421, 24706874; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390218.1" /db_xref="EnsemblGenomes-Gn:BSU23370" /db_xref="EnsemblGenomes-Tr:CAB14269" /db_xref="InterPro:IPR009343" /db_xref="SubtiList:BG10511" /db_xref="UniProtKB/Swiss-Prot:P31847" /translation="MKKIWIGMLAAAVLLLMVPKVSLADAAVGDVIVTLGADLSESDK QKVLDEMNVPDNATTVTVTNKEEHEYLGKYISNAQIGSRAISSSSITIAKKGSGLNVE THNISGITDEMYLNALMTAGVKDAKVYVTAPFEVSGTAALTGLIKAYEVSSDEAISED VKQVANQELVTTSELGDKIGNENAAALIAKIKEEFAKNGVPDNKADIEKQVDDAASDL NVTLTDSQKNQLVSLFNKMKNADIDWGQVSDQLDKAKDKITKFIESDEGKNFIQKVID FFVSIWNAIVSIFK*" /label="ypuA CDS" gene 2029194..2030066 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /label="ypuA gene" downshifts 2029973 /Source="Nicolas_upshifts" /id="D1222" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="5.9994" /MaxDrop="4.15288" /score="27.7277161" /energy="-12.7" /TU="U1829" /idTUdmin="U1829" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 2030039 /Source="Nicolas_upshifts" /id="D1223" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="1.98749" /MaxDrop="5.95835" /score="27.7277161" /energy="-12.7" /TU="NA" /idTUdmin="U1829" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2030096..2031415) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /EC_number="4.1.1.20" /experiment="publication(s) with functional evidences, PMID:9044297, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9044297, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-2,6-diaminopimelate decarboxylase" /protein_id="NP_390219.1" /db_xref="EnsemblGenomes-Gn:BSU23380" /db_xref="EnsemblGenomes-Tr:CAB14270" /db_xref="GOA:P23630" /db_xref="InterPro:IPR000183" /db_xref="InterPro:IPR002986" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR022643" /db_xref="InterPro:IPR022644" /db_xref="InterPro:IPR022653" /db_xref="InterPro:IPR022657" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10510" /db_xref="UniProtKB/Swiss-Prot:P23630" /translation="MFLHGTSRQNQHGHLEIGGVDALYLAEKYGTPLYVYDVALIRER AKSFKQAFISAGLKAQVAYASKAFSSVAMIQLAEEEGLSLDVVSGGELYTAVAAGFPA ERIHFHGNNKSREELRMALEHRIGCIVVDNFYEIALLEDLCKETGHSIDVLLRITPGV EAHTHDYITTGQEDSKFGFDLHNGQTERAIEQVLQSEHIQLLGVHCHIGSQIFDTAGF VLAAEKIFKKLDEWRDSYSFVSKVLNLGGGFGIRYTEDDEPLHATEYVEKIIEAVKEN ASRYGFDIPEIWIEPGRSLVGDAGTTLYTVGSQKEVPGVRQYVAVDGGMNDNIRPALY QAKYEAAAANRIGEAHDKTVSIAGKCCESGDMLIWDIDLPEVKEGDLLAVFCTGAYGY SMANNYNRIPRPAVVFVENGEAHLVVKRETYEDIVKLDLPFKTGVKQ*" /label="lysA CDS" gene complement(2030096..2031415) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /label="lysA gene" downshifts complement(2030116) /Source="Nicolas_upshifts" /id="D1224" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.99445" /MaxDrop="5.13504" /score="28.6775009" /energy="-12.7" /TU="NA" /idTUdmin="U1830" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2031416..2031480) /Source="Nicolas_S_feature" /locus_tag="new_2438267_2438331_c" /HighExp="C90, HiOs, BMM, GM 120, GM 25, MG-0.2, GM 15, GM-0.2, MG t5, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S888" promotor_-10 complement(2031476..2031495) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2031480) /Source="Nicolas_upshifts" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2031510..2031517) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2031521..2032139) /gene="spoVAF" /locus_tag="PG10_5'_ext_BSU_23390" /old_locus_tag="BSU_23390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 17573930, 24682327, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 17573930, 24682327, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AF" /protein_id="NP_390220.2" /db_xref="EnsemblGenomes-Gn:BSU23390" /db_xref="EnsemblGenomes-Tr:CAB14271" /db_xref="GOA:P31845" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10508" /db_xref="UniProtKB/Swiss-Prot:P31845" /modified_by="User" /translation="MTTSSGKIFRYSCFYFISSDLVSLCASA*SAPGQHEIYRFK*RY AYPDHPADIFS*LRNRVSQNGCHSHTDGFIDSNGFNCRCSDRADCD*GRPFFS*GDSV RLTCGDWNLYDA*L*IKLGKQNEPSCPHDTRCFISYKRARHRIYSANYCHGKHQIPSD TVLMAADSL*RKGAVAGSCPHSETWRKSKTQHRSPQKSLKAAYQFI" /label="PG10_5'_ext_BSU_23390" gene complement(2031521..2032139) /gene="PG10_5'_ext_BSU_23390" /locus_tag="PG10_pseudo_BSU_23390" /old_locus_tag="BSU_23390" /modified_by="User" /label="PG10_5'_ext_BSU_23390" SCAR join(2032125,2032132) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs23" N_region 2032126..2032131 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs23" S_feature complement(<2032132..2032148) /Source="Nicolas_S_feature" /locus_tag="new_2445036_2445093_c" /HighExp="S4, S3, S7, S5, S8, S6, T5.0H, BT, LoTm, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.859" /TUlongSig="NA" /TUlongPSig="NA" /label="S889" CDS complement(2032149..2033318) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /EC_number="3.4.16.4" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8021191, 8936302, 9864321, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021191, 8936302, 9864321, 19189487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicilin binding protein)" /protein_id="NP_390229.1" /db_xref="EnsemblGenomes-Gn:BSU23480" /db_xref="EnsemblGenomes-Tr:CAB14280" /db_xref="GOA:P38422" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10295" /db_xref="UniProtKB/Swiss-Prot:P38422" /translation="MKRLLSTLLIGIMLLTFAPSAFAKQDGKRTSELAHEAKSAVLIE RDTGKVLYNKNSNERLAPASMTKIMTMLLIMEALDKGKIKMSDKVRTSEHAASMGGSQ IFLEPGEEMTVKEMLKGIAIASGNDASVAMAEFISGSEEEFVKKMNKKAKELGLKNTS FKNPTGLTEEGHYSSAYDMAIMAKELLKYESITKFTGTYEDYLRENTDKKFWLVNTNR LIKFYPGVDGVKTGYTGEAKYCLTASAKKGNMRAIAVVFGASTPKERNAQVTKMLDFA FSQYETHPLYKRNQTVAKVKVKKGKQKFIELTTSEPISILTKKGEDMNDVKKEIKMKD NISAPIQKGQELGTLVLKKDGEVLAESPVAAKEDMKKAGFITFLKRTMGDWTKFK*" /label="dacF CDS" gene complement(2032149..2033318) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /label="dacF gene" promotor_-10 complement(2033347..2033358) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2033362) /Source="Nicolas_upshifts" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2033372..2033378) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2033464) /Source="Nicolas_upshifts" /id="D1226" /incds=0 /nref=243 /ntot=267 /MaxReadThrough="0.87114" /MaxDrop="7.5376" /score="26.8559416" /energy="-16.7" /TU="NA" /idTUdmin="U1836" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2033473..2034288) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 15530033, 21279421, 21543875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 15530033, 21279421, 21543875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_390230.1" /db_xref="EnsemblGenomes-Gn:BSU23490" /db_xref="EnsemblGenomes-Tr:CAB14281" /db_xref="GOA:P46354" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR011268" /db_xref="InterPro:IPR011270" /db_xref="InterPro:IPR018099" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG11330" /db_xref="UniProtKB/Swiss-Prot:P46354" /translation="MKDRIERAAAFIKQNLPESPKIGLILGSGLGILADEIENPVKLK YEDIPEFPVSTVEGHAGQLVLGTLEGVSVIAMQGRFHFYEGYSMEKVTFPVRVMKALG VEALIVTNAAGGVNTEFRAGDLMIITDHINFMGTNPLIGPNEADFGARFPDMSSAYDK DLSSLAEKIAKDLNIPIQKGVYTAVTGPSYETPAEVRFLRTMGSDAVGMSTVPEVIVA NHAGMRVLGISCISNAAAGILDQPLSHDEVMEVTEKVKAGFLKLVKAIVAQYE*" /label="pupG CDS" gene complement(2033473..2034288) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /label="pupG gene" CDS complement(2034301..2035485) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /EC_number="5.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,5-phosphopentomutase" /protein_id="NP_390231.2" /db_xref="EnsemblGenomes-Gn:BSU23500" /db_xref="EnsemblGenomes-Tr:CAB14282" /db_xref="GOA:P46353" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR010045" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR024052" /db_xref="SubtiList:BG11331" /db_xref="UniProtKB/Swiss-Prot:P46353" /translation="MPAYKYNRVFLIVMDSVGIGEAPDAADFNDEGAHTLGHIAEHMN GLHMPNMAKLGLGLIEDIKGVEKTEHPLAYYGKMQEASNGKDTMTGHWEIMGLYIDKP FKVFPEGFPDELLQELEKRSGRKIIGNKPASGTAILDELGQEHMETGALIVYTSADSV LQIAAHEEVVPLEELYRICETARELTLDPKYMVGRIIARPFVGEPGQFKRTPNRHDYA LKPFDRTVMNELKDCGLDVISIGKISDIYDGEGITSSRRTVSNMDGMDKVIDTLGEDF TGLSFANLVDFDALFGHRRDPEGYGRALEEFDARLPEVFEKMREDDLLIITADHGNDP IHHGTDHTREYVPILAYSKKHKKAQMLPLADTFADIGATIADNFQTNKPKYGKSFLSL LQ*" /label="deoB CDS" gene complement(2034301..2035485) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /label="deoB gene" promotor_-10 complement(2035534..2035553) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2035552) /Source="Nicolas_upshifts" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2035554..2035645) /Source="Nicolas_S_feature" /locus_tag="new_2448499_2448590_c" /HighExp="S3, S4, M0t90, G180, S7, S8, Glucon, G135, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigEF, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S890" promotor_-35 complement(2035569..2035576) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2035646..2036536) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_390232.2" /db_xref="EnsemblGenomes-Gn:BSU23510" /db_xref="EnsemblGenomes-Tr:CAB14283" /db_xref="GOA:P46352" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011932" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG11332" /db_xref="UniProtKB/Swiss-Prot:P46352" /translation="MKDQIKDFIHYVMVERGLSQNTIVSYERDLKSYSLYLTETLHVT DWNHVTRIHIIQYLKHLKDSGKSGKTSARHLASIRSFHQFLLREKVTDKDPSVHIETQ KTERALPKVLALNEVERLLDTPKLTSPFGYRDKAMLELLYATGIRVSEMIELKTADVH LSMGFIRCFGKGRKERIVPIGEAAASAIEEYMTKARGKLLKNNVSDALFLNHHGKQIS RQGFWKNLKKIALEAGIKKELTPHTLRHSFATHLLENGADLRAVQEMLGHADISTTQI YTHVTKTRLKDVYKQFHPRA*" /label="ripX CDS" gene complement(2035646..2036536) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /label="ripX gene" CDS complement(2036544..2036771) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097760.1" /db_xref="EnsemblGenomes-Gn:BSU23519" /db_xref="EnsemblGenomes-Tr:CAX52660" /db_xref="GOA:C0H451" /db_xref="InterPro:IPR025321" /db_xref="UniProtKB/Swiss-Prot:C0H451" /translation="MGRFLKTAVDALKVFILFTGFTALFYYAMIWVNQEYENYHRYDK PEGSAVKVVEMDQDEKGGWFDRLIFFYQNGE*" /label="yqzK CDS" gene complement(2036544..2036771) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /label="yqzK gene" promotor_-10 complement(2036674..2036693) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2036685) /Source="Nicolas_upshifts" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2036707..2036714) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2036764) /Source="Nicolas_upshifts" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2036773..2036791) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2036801..2036819) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2036807..2036813) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2036814) /Source="Nicolas_upshifts" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2036836..2036841) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2036896) /Source="Nicolas_upshifts" /id="D1227" /incds=0 /nref=159 /ntot=251 /MaxReadThrough="4.06128" /MaxDrop="5.73495" /score="5.40881961" /energy="-8.1" /TU="U1840" /idTUdmin="U1841" /TUdmin=506 /isTUend="FALSE" /label="downshifts" CDS complement(2036896..2037345) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for iron transport andmetabolism" /protein_id="NP_390233.2" /db_xref="EnsemblGenomes-Gn:BSU23520" /db_xref="EnsemblGenomes-Tr:CAB14284" /db_xref="GOA:P54574" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11766" /db_xref="UniProtKB/Swiss-Prot:P54574" /translation="MENRIDRIKKQLHSSSYKLTPQREATVRVLLENEEDHLSAEDVY LLVKEKSPEIGLATVYRTLELLTELKVVDKINFGDGVSRYDLRKEGAAHFHHHLVCME CGAVDEIEEDLLEDVEEIIERDWKFKIKDHRLTFHGICHRCNGKETE*" /label="fur CDS" gene complement(2036896..2037345) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /label="fur gene" promotor_-10 complement(2037369..2037388) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-10" upshifts complement(2037379) /Source="Nicolas_upshifts" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="upshifts" S_feature complement(2037381..2037457) /Source="Nicolas_S_feature" /locus_tag="new_2450326_2450402_c" /HighExp="S3, S4, S5, BT, LoTm, M9-stat, T5.0H, T3.30H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S891" promotor_-35 complement(2037404..2037408) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-35" CDS complement(2037458..2038102) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17376078, 17824930, 20382772, 23859254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17376078, 17824930, 20382772, 23859254; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="autolysin component for dissolution of the septal cell wall (stage II sporulation)" /protein_id="NP_390234.1" /db_xref="EnsemblGenomes-Gn:BSU23530" /db_xref="EnsemblGenomes-Tr:CAB14285" /db_xref="GOA:P37873" /db_xref="InterPro:IPR002798" /db_xref="InterPro:IPR014196" /db_xref="SubtiList:BG10768" /db_xref="UniProtKB/Swiss-Prot:P37873" /translation="MRKISYKDMFLRHVKDHLSLYIFVSVLFFMGVIFGAIIVNSMTI SQKEDLYYYLSQFFGQLSDGKQASSADMFGQSIFHNAKYLGLMWILGISVIGMPIIFI MIFLKGIVVGFTVGFLVNQMGVSGFFLSFVSVLPQNVLLIPAYLIMGTCAIAFSLKLI RQLFVKRSLHDAPIQWFGRYAFVLLVILFLALISSLFEAYLSPVLMEKLTSRLF*" /label="spoIIM CDS" gene complement(2037458..2038102) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /label="spoIIM gene" promotor_-10 complement(2038133..2038151) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-10" upshifts complement(2038150) /Source="Nicolas_upshifts" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="upshifts" promotor_-35 complement(2038166..2038171) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-35" CDS complement(2038203..2038418) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390235.1" /db_xref="EnsemblGenomes-Gn:BSU23540" /db_xref="EnsemblGenomes-Tr:CAB14286" /db_xref="SubtiList:BG11765" /db_xref="UniProtKB/Swiss-Prot:P54573" /translation="MAKSQAKKKRGHRLRNGGRDVLLSRGSTPSFSTHGRMTKSKKEI LNKRKHKNPYDHTAVDDKDFFVPQKAA*" /label="yqkK CDS" gene complement(2038203..2038418) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /label="yqkK gene" downshifts complement(2038283) /Source="Nicolas_upshifts" /id="D1228" /incds=1 /nref=17 /ntot=130 /MaxReadThrough="0.857610000000001" /MaxDrop="3.7055" /score="1.77181315" /energy="-9.8" /TU="NA" /idTUdmin="U1842" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2038518..2039837) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 23136871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catabolic NAD-dependent malic enzyme (conversionof malate into pyruvate)" /protein_id="NP_390236.1" /db_xref="EnsemblGenomes-Gn:BSU23550" /db_xref="EnsemblGenomes-Tr:CAB14287" /db_xref="GOA:P54572" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11764" /db_xref="UniProtKB/Swiss-Prot:P54572" /translation="MIAKHMIRTLMIETPSVPGNLGRVATAIGLLGGDIGEVETVKVG PNYTMRNITVQVENEEQLQEVIAAVQALGEGIRLHTVSDEVLSAHEGGKIQMKSKMPI RSLAELGRVYTPGVADVCRLIEKEPEKASIYTTISNSVAIVTDGTAILGLGNIGSVAG MPVMEGKAALFDQLAGISGIPILLDTSDPEEIIKTVKHISPGFSGILLEDIGSPHCFE IEDRLKEELNIPVMHDDQHGTAVVTLAAAISACRSAGVDLKEAKVGQIGLGAAGVAIC RMFMAYGVNAVYGTDKSESAMNRLEQYGGQAVSSIEELMETCDIVIATTGVPGLIKPA FVRSGQVILALSNPKPEIEPEAALQAGAAYAADGRSVNNVLGFPGIFRGALNAKSTEI NHDMLVAAAEAIAACTKQGDVVPQPLDSKVHHAVAAAVEHAALTAVK*" /label="mleA CDS" gene complement(2038518..2039837) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /label="mleA gene" downshifts complement(2038525) /Source="Nicolas_upshifts" /id="D1229" /incds=0 /nref=29 /ntot=84 /MaxReadThrough="3.50516" /MaxDrop="5.65279" /score="42.1653011" /energy="-15.2" /TU="U1842,U1843" /idTUdmin="U1842" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" CDS complement(2039855..2041261) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10903309, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10903309, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="malate-H+/Na+-lactate antiporter" /protein_id="NP_390237.1" /db_xref="EnsemblGenomes-Gn:BSU23560" /db_xref="EnsemblGenomes-Tr:CAB14288" /db_xref="GOA:P54571" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG11763" /db_xref="UniProtKB/Swiss-Prot:P54571" /translation="MKDVRLPTLFEIIIVLGVFLALVLSFTVFLDLPIQLALFVSWFI AMLLGIRLGYSYKDLQNAIVHGISNGLEAVLILVSVGALIGTWIAGGVVPTLIYYGLE FIHPSIFLLATLIICSIMSVATGTSWGTVGTAGIAMIAIGEGLGIPLPLVAGAILSGA YFGDKLSPLSDSTVLASSLSKVDVLAHVRAMLYLSIPAYVITAILFTVVGFMYGGKNI DLDKVEFLKSSLQNTFDIHIWMLIPAVLVIVLLAMKKPSMPVIVIGALLGAIWAVVFQ GMDIAHAIATAYNGFSIKTDVEFLNGLLNRGGIVGMLDSLVVIIFGLGFGGLLEKLGV LKVIVSTFEKKLTSAGNVTLSTLIVAFLANIFGCAMYVSLILTPKIMEDSYDRLHLDR RVLSRNSEVGGTLTSGMVPWSDNGIYMAGILGVSTFSYLPFMWLSFVAIGLAIIYGYT GKFIWYTKNNTVKAEKLG*" /label="mleN CDS" gene complement(2039855..2041261) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /label="mleN gene" promotor_-10 complement(2041309..2041328) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2041318) /Source="Nicolas_upshifts" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2041320..2041401) /Source="Nicolas_S_feature" /locus_tag="new_2454265_2454346_c" /HighExp="S0, dia0, dia5, Lbexp, G150, Oxctl, G135, Mt0, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S892" promotor_-35 complement(2041343..2041350) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2041402..2042829) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /EC_number="4.3.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-aspartase (aspartate ammonia lyase)" /protein_id="NP_390238.2" /db_xref="EnsemblGenomes-Gn:BSU23570" /db_xref="EnsemblGenomes-Tr:CAB14289" /db_xref="GOA:P26899" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004708" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10301" /db_xref="UniProtKB/Swiss-Prot:P26899" /translation="MLNGQKEYRVEKDFLGEKQIEADVYYGIQTLRASENFPITGYKI HEEMINALAIVKKAAALANMDVKRLYEGIGQAIVQAADEILEGKWHDQFIVDPIQGGA GTSMNMNANEVIGNRALEIMGHKKGDYIHLSPNTHVNMSQSTNDVFPTAIHISTLKLL EKLLKTMEDMHSVFKQKAQEFDSVIKMGRTHLQDAVPIRLGQEFEAYSRVLERDIKRI KQSRQHLYEVNMGATAVGTGLNADPEYIKQVVKHLADISGLPLVGADHLVDATQNTDA YTEVSASLKVCMMNMSKIANDLRLMASGPRAGLAEISLPARQPGSSIMPGKVNPVMAE LINQIAFQVIGNDNTICLASEAGQLELNVMEPVLVFNLLQSISIMNNGFRSFTDNCLK GIEANEKRMKQYVEKSAGVITAVNPHLGYEAAARIAREAIMTGQSVRDLCLQHDVLTE EELDIILNPYEMTKPGIAGKELLEK*" /label="ansB CDS" gene complement(2041402..2042829) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /label="ansB gene" CDS complement(2042874..2043863) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /EC_number="3.5.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029, 11914346, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029, 11914346, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported L-asparaginase" /protein_id="NP_390239.1" /db_xref="EnsemblGenomes-Gn:BSU23580" /db_xref="EnsemblGenomes-Tr:CAB14290" /db_xref="GOA:P26900" /db_xref="InterPro:IPR006033" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG10300" /db_xref="UniProtKB/Swiss-Prot:P26900" /translation="MKKLLMLTTGGTIASVEGENGLAPGVKADELLSYVSKLDNDYTM ETQSLMNIDSTNMQPEYWVEIAEAVKENYDAYDGFVITHGTDTMAYTSAALSYMLQHA KKPIVITGSQIPITFQKTDAKKNITDAIRFACEGVGGVYVVFDGRVIQGTRAIKLRTK SYDAFESINYPYIAFINEDGIEYNKQVTEPENDTFTVDTSLCTDVCLLKLHPGLKPEM FDALKSMYKGIVIESYGSGGVPFEGRDILSKVNELIESGIVVVITTQCLEEGEDMSIY EVGRRVNQDLIIRSRNMNTEAIVPKLMWALGQSSDLPVVKRIMETPIADDVVL*" /label="ansA CDS" gene complement(2042874..2043863) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /label="ansA gene" S_feature complement(2043864..2043943) /Source="Nicolas_S_feature" /locus_tag="new_2456809_2456888_c" /HighExp="dia0, Lbexp, G150, Oxctl, dia5, LBGexp, Paraq, C30, G180, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S893" promotor_-10 complement(2043925..2043944) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2043943) /Source="Nicolas_upshifts" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2043945..2044265) /Source="Nicolas_S_feature" /locus_tag="new_2456890_2457210_c" /HighExp="LBGstat, S5, G135, S8, S6, LBGtran, G180, G150, LoTm, LBGexp" /AntisenseName="ansR" /AntisenseCor="0.23077291929287899" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S894" promotor_-35 complement(2043959..2043966) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2043984..2043991 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2044004..2044023 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2044006 /Source="Nicolas_upshifts" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="upshifts" CDS 2044045..2044395 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of ansAB (Xre family)" /protein_id="NP_390240.1" /db_xref="EnsemblGenomes-Gn:BSU23590" /db_xref="EnsemblGenomes-Tr:CAB14291" /db_xref="GOA:Q07683" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR027910" /db_xref="SubtiList:BG10299" /db_xref="UniProtKB/Swiss-Prot:Q07683" /translation="MNLDRLTELRKKKNWSLQYTADLLGIAKSTYAGYESGYRRPSLE ALAMLADLFDTTCDELLGREKQKQTAPQAIELATWSSLDFTISVDGQPLSEDEIIQLI TFIRTKRKVQEELS*" /label="ansR CDS" gene 2044045..2044395 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /label="ansR gene" S_feature complement(2044267..2044403) /Source="Nicolas_S_feature" /locus_tag="new_2457212_2457348_c" /HighExp="LBGstat, S8, S6, S7, S5, ferm, nit, LBGtran, BT, LPhT" /AntisenseName="ansR" /AntisenseCor="-0.22421651781702501" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S895" downshifts complement(2044310) /Source="Nicolas_upshifts" /id="D1230" /incds=1 /nref=4 /ntot=116 /MaxReadThrough="3.90926" /MaxDrop="4.76642" /score="10.2434094" /energy="-23.6" /TU="U1847" /idTUdmin="U1845" /TUdmin=1451 /isTUend="FALSE" /label="downshifts" CDS complement(2044404..2045567) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleotide binding protein" /protein_id="NP_390241.2" /db_xref="EnsemblGenomes-Gn:BSU23600" /db_xref="EnsemblGenomes-Tr:CAB14292" /db_xref="GOA:P38423" /db_xref="InterPro:IPR005287" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG11073" /db_xref="UniProtKB/Swiss-Prot:P38423" /translation="MKKIYADLHIHIGRTFTGRAVKITGAKTLTLDRILVEASEHKGI ELLGIIDCHSPEVILELEEGISSGKYRELDGGGIRYRSTTLLLGSELEIYDEACSGPI HVLVFMPTLADMKQFSNWLSARLKNIHLSSQRIYETGLNLQKKVQDMGGLFIPAHIFT PHKSLYGKGVKSSLTEVFDPSMIDAVELGLSCDTDMASHVSQLNPYPFLTNSDAHSLG KIGREYNELYVQSADFTEFALALKGQDDRKIIANYGLDPLLGKYYQTACEACGEPAVS GETACANCGKARFTKGVSDRLRELSDQLEVRVPRPRYVHQIPLQFVPGVGPKTLDKLK KAFGTEMAVLHEAAEEDLARVVPPKTAALIVKARSGKLELKAGGGGTYGKIKP*" /label="yqxK CDS" gene complement(2044404..2045567) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /label="yqxK gene" CDS complement(2045564..2046121) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /EC_number="3.1.7.1" /EC_number="3.6.1.13" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10542272, 17693564, 21638333, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl pyrophosphate and dimethylallyl pyrophosphate diphosphatase (moonlighting ADP-ribose pyrophosphatase)" /protein_id="NP_390242.1" /db_xref="EnsemblGenomes-Gn:BSU23610" /db_xref="EnsemblGenomes-Tr:CAB14293" /db_xref="GOA:P54570" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11762" /db_xref="UniProtKB/Swiss-Prot:P54570" /translation="MKSLEEKTIAKEQIFSGKVIDLYVEDVELPNGKASKREIVKHPG AVAVLAVTDEGKIIMVKQFRKPLERTIVEIPAGKLEKGEEPEYTALRELEEETGYTAK KLTKITAFYTSPGFADEIVHVFLAEELSVLEEKRELDEDEFVEVMEVTLEDALKLVES REVYDAKTAYAIQYLQLKEALQAQK*" /label="nudF CDS" gene complement(2045564..2046121) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /label="nudF gene" promotor_no_box complement(2046051..2046151) /Source="Nicolas_upshift_promotors" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2046091) /Source="Nicolas_upshifts" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2046135..2046140 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2046156..2046174 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2046158..2046172) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-10" upshifts 2046162 /Source="Nicolas_upshifts" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="upshifts" S_feature 2046169..2046343 /Source="Nicolas_S_feature" /locus_tag="new_2459114_2459288" /HighExp="S4, S5, S3, S7, S6, LoTm, BT, T5.0H, G/S, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99962399999999996" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S896" promotor_-35 complement(2046174..2046177) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-35" upshifts complement(2046177) /Source="Nicolas_upshifts" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="upshifts" CDS 2046196..2046318 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /function="15.1: Cell division" /experiment="publication(s) with functional evidences, PMID:18284588, 23237472, 25848052, 27752253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18284588, 23237472, 25848052, 27752253; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="YP_009513976.1" /db_xref="EnsemblGenomes-Gn:BSU23616" /db_xref="EnsemblGenomes-Tr:CCQ48600" /db_xref="GOA:L8EBJ9" /db_xref="InterPro:IPR025177" /db_xref="PDB:2MRW" /db_xref="PDB:4U39" /db_xref="UniProtKB/TrEMBL:L8EBJ9" /translation="MKVHRMPKGVVLVGKAWEIRAKLKEYGRTFQYVKDWISKP*" /label="mciZ CDS" gene 2046196..2046318 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /label="mciZ gene" promotor_-35 2046319..2046326 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2046340..2046359 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2046345 /Source="Nicolas_upshifts" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="upshifts" CDS 2046381..2047301 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /EC_number="1.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9643546, 15317791, 16242712, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent aldo-keto reductase (acts on 4-hydroxy-2,3-trans-nonenal)" /protein_id="NP_390243.1" /db_xref="EnsemblGenomes-Gn:BSU23620" /db_xref="EnsemblGenomes-Tr:CAB14294" /db_xref="GOA:P54569" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11761" /db_xref="UniProtKB/Swiss-Prot:P54569" /translation="MRKRKLGTSDLDISEVGLGCMSLGTEKNKALSILDEAIELGINY LDTADLYDRGRNEEIVGDAIQNRRHDIILATKAGNRWDDGSEGWYWDPSKAYIKEAVK KSLTRLKTDYIDLYQLHGGTIEDNIDETIEAFEELKQEGVIRYYGISSIRPNVIKEYV KKSNIVSIMMQFSLFDRRPEEWLPLLEEHQISVVARGPVAKGLLTEKPLDQASESMKQ NGYLSYSFEELTNARKAMEEVAPDLSMTEKSLQYLLAQPAVASVITGASKIEQLRENI QAANARRLTEEEIKALQSHTKQDIYKAHRS*" /label="yqkF CDS" gene 2046381..2047301 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /label="yqkF gene" downshifts 2047290 /Source="Nicolas_upshifts" /id="D1231" /incds=0 /nref=186 /ntot=248 /MaxReadThrough="1.49159" /MaxDrop="5.81013" /score="18.6018806" /energy="-14.8" /TU="NA" /idTUdmin="U1846" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2047333..2047557) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390244.1" /db_xref="EnsemblGenomes-Gn:BSU23630" /db_xref="EnsemblGenomes-Tr:CAB14295" /db_xref="InterPro:IPR024980" /db_xref="SubtiList:BG11760" /db_xref="UniProtKB/Swiss-Prot:P54568" /translation="MKKQKSIDKHQLKDGLQSDIKAKLMEMKSQLKEEDEKRQKREKA EQIRKKKEIEKNKSFEELLNESQMDWHQYK*" /label="yqkE CDS" gene complement(2047333..2047557) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /label="yqkE gene" downshifts complement(2047390) /Source="Nicolas_upshifts" /id="D1232" /incds=0 /nref=19 /ntot=195 /MaxReadThrough="0.59953" /MaxDrop="5.9087" /score="15.8160537" /energy="-13" /TU="NA" /idTUdmin="U1849" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2047580..2047599) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2047587) /Source="Nicolas_upshifts" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2047614..2047621) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2047636..2047643 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2047658..2047677 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2047665 /Source="Nicolas_upshifts" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="upshifts" CDS 2047719..2048636 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390245.1" /db_xref="EnsemblGenomes-Gn:BSU23640" /db_xref="EnsemblGenomes-Tr:CAB14296" /db_xref="GOA:P54567" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11759" /db_xref="UniProtKB/Swiss-Prot:P54567" /translation="MKKILLAIGALVTAVIAIGIVFSHMILFIKKKTDEDIIKRETDN GHDVFESFEQMEKTAFVIPSAYGYDIKGYHVAPHDTPNTIIICHGVTMNVLNSLKYMH LFLDLGWNVLIYDHRRHGQSGGKTTSYGFYEKDDLNKVVSLLKNKTNHRGLIGIHGES MGAVTALLYAGAHCSDGADFYIADCPFACFDEQLAYRLRAEYRLPSWPLLPIADFFLK LRGGYRAREVSPLAVIDKIEKPVLFIHSKDDDYIPVSSTERLYEKKRGPKALYIAENG EHAMSYTKNRHTYRKTVQEFLDNMNDSTE*" /label="yqkD CDS" gene 2047719..2048636 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /label="yqkD gene" downshifts 2048611 /Source="Nicolas_upshifts" /id="D1233" /incds=0 /nref=27 /ntot=171 /MaxReadThrough="2.02201" /MaxDrop="3.99393" /score="14.106821" /energy="-11.8" /TU="NA" /idTUdmin="U1850" /TUdmin=594 /isTUend="FALSE" /label="downshifts" CDS complement(2048676..2048915) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390246.1" /db_xref="EnsemblGenomes-Gn:BSU23650" /db_xref="EnsemblGenomes-Tr:CAB14297" /db_xref="InterPro:IPR020157" /db_xref="SubtiList:BG11758" /db_xref="UniProtKB/Swiss-Prot:P54566" /translation="MEQKLKAMKNTAQNKTWVSFLNQNHPYTLLHWSIGGAESIKKDV WLLQDEMTFETQEFTTIDLAIEWIRENMDGITDVL*" /label="yqkC CDS" gene complement(2048676..2048915) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /label="yqkC gene" downshifts complement(2048687) /Source="Nicolas_upshifts" /id="D1234" /incds=0 /nref=215 /ntot=269 /MaxReadThrough="3.31829" /MaxDrop="6.35785" /score="16.3526162" /energy="-11.2" /TU="NA" /idTUdmin="U1851" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2048928..2049251) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390247.1" /db_xref="EnsemblGenomes-Gn:BSU23660" /db_xref="EnsemblGenomes-Tr:CAB14298" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11757" /db_xref="UniProtKB/Swiss-Prot:P54565" /translation="MNIHVTDAAKQALQQAFDANPGKKAQLRYDAEGCGCAVSGVPTI WLAEELTGQCEQLETNGIPLYIQSSQKVFFDDQMTIDYNEKAKTLALKSPAEMLSPRM SILVK*" /label="yqkB CDS" gene complement(2048928..2049251) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /label="yqkB gene" promotor_-10 complement(2048994..2049013) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2048995) /Source="Nicolas_upshifts" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2049027..2049034) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2049248..2050279) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390248.1" /db_xref="EnsemblGenomes-Gn:BSU23670" /db_xref="EnsemblGenomes-Tr:CAB14299" /db_xref="GOA:P54564" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR007344" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11756" /db_xref="UniProtKB/Swiss-Prot:P54564" /translation="MIEFLQHKEATIAREILAVQIPAYIKETEIIGFDGIPALQEKVK DIQASHERFAGYRKNGKLIGVISYEKNMHYLTICRLVVHPDGFRKGIGRALLQFVIDH NEDAEKIEVVTAENNTPAVSLYTQAGFQKAETVKAAQGLLLSVFHLYPKRKVEIILYN EKWAECFDEEKERLKLVFGPEIIAIHHIGSTSIPNMAAKPIIDMLIEVRSIEAVSQFD EQMKANGYTPKGENGIAGRRYFQKGGNKRTHHVHMYEQGNPAIERHLLFRDYLRAHPN IAKEYAVLKKQLAAQHPDSINQYIQGKDEWIKTAEENAKRWKKGRNNANGSIVCYNSE NDENGGFTL*" /label="yqkA CDS" gene complement(2049248..2050279) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /label="yqkA gene" promotor_-10 complement(2049275..2049294) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2049282) /Source="Nicolas_upshifts" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2049305..2049312) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2050272..2050616) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradation enzyme (oxygenase)" /protein_id="NP_390249.1" /db_xref="EnsemblGenomes-Gn:BSU23680" /db_xref="EnsemblGenomes-Tr:CAB14300" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:2GO8" /db_xref="SubtiList:BG11755" /db_xref="UniProtKB/Swiss-Prot:P54563" /translation="MMDFLSKTPEPPYYAVIFSSVKSENDTGYGETAERMVSLAADQP GFLGVESVREADGRGITVSYWDSMDAINHWRHHTEHQAAKEKGRSVWYESYAVRVAKV DRQRLFQENTND*" /label="yqjZ CDS" gene complement(2050272..2050616) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /label="yqjZ gene" CDS complement(2050626..2051096) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390250.1" /db_xref="EnsemblGenomes-Gn:BSU23690" /db_xref="EnsemblGenomes-Tr:CAB14301" /db_xref="GOA:P54562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017255" /db_xref="PDB:1MK4" /db_xref="SubtiList:BG11754" /db_xref="UniProtKB/Swiss-Prot:P54562" /translation="MDIRTITSSDYEMVTSVLNEWWGGRQLKEKLPRLFFEHFQDTSF ITSEHNSMTGFLIGFQSQSDPETAYIHFSGVHPDFRKMQIGKQLYDVFIETVKQRGCT RVKCVTSPVNKVSIAYHTKLGFDIEKGTKTVNGISVFANYDGPGQDRVLFVKNI*" /label="yqjY CDS" gene complement(2050626..2051096) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /label="yqjY gene" S_feature complement(2051097..2051173) /Source="Nicolas_S_feature" /locus_tag="new_2464042_2464118_c" /HighExp="SMM, T-4.40H, MG 150, M9-tran, GM 90, T-3.40H, GM-0.2, M9-exp, GM 120, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigEF" /TUlongPSig="0.776" /label="S897" downshifts 2051097 /Source="Nicolas_upshifts" /id="D1235" /incds=0 /nref=8 /ntot=121 /MaxReadThrough="0.87367" /MaxDrop="3.61005" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2051148..2051167) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2051173) /Source="Nicolas_upshifts" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2051175..2051281) /Source="Nicolas_S_feature" /locus_tag="new_2464120_2464226_c" /HighExp="M40t90, S4, M40t45, S6, H2O2, S5, S3, S8, S7, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.776" /TUlongSig="NA" /TUlongPSig="NA" /label="S898" promotor_-35 complement(2051182..2051189) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2051282..2051620) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12137951, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390251.1" /db_xref="EnsemblGenomes-Gn:BSU23700" /db_xref="EnsemblGenomes-Tr:CAB14302" /db_xref="GOA:P54561" /db_xref="InterPro:IPR014962" /db_xref="SubtiList:BG11753" /db_xref="UniProtKB/Swiss-Prot:P54561" /translation="MNDHLKRGNLLWEGSRMFLPEHKQSLLERKRLKQKLQKPILDPD KLEEMNQTLCAAMEFAQDITVSCFQDGEIVCCTGKICRYEEFEKAVWIKGDEDQLYKL KLDQVLDIVL*" /label="yqjX CDS" gene complement(2051282..2051620) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /label="yqjX gene" CDS complement(2051617..2052855) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /EC_number="2.7.7.7" /function="16.5: Explore" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Y family DNA polymerase V bypassing lesions during replication" /protein_id="NP_390252.1" /db_xref="EnsemblGenomes-Gn:BSU23710" /db_xref="EnsemblGenomes-Tr:CAB14303" /db_xref="GOA:P54560" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11752" /db_xref="UniProtKB/Swiss-Prot:P54560" /translation="MMKEKVIFLVDMQSFYASVEKAENPHLKNRPVIVSGDPEKRGGV VLAACPLAKQKGVVNASRLWEAQEKCPEAVVLRPRMQRYIDVSLQITAILEEYTDLVE PYSIDEQFMDITGSQKLFGTPMEIAKSIQGRIMREIGVYARVGIGPNKALAKIACDNF AKKNKNGIFTLTKENMKTEMWPLPVGSMFGVGSRMKHHLNRMGISTIGGLAAFPLDLL KKKWGINGHVLWMTANGIDYSPVSTSSLDGQKAIGHGMTLPRDYEHFDKEIKVVLLEL SEEVCRRSRNAGVMGQTVSVSCRGADFDWPTGFNRQVKLAEPTNSTQDVYEAVRRLFL TFWDGKPVRRLGVNLSQLSSDDIWQLNLFQDYAKKMSLGYVMDGIKNRFGDTAIIRAA SLTAAGQAFERAAKIGGHYK*" /label="polYB CDS" gene complement(2051617..2052855) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /label="polYB gene" misc_feature 2051779..2051780 /Source="Nicolas_upshift_promotors" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2051790 /Source="Nicolas_upshifts" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2051845 /Source="Nicolas_upshifts" /id="D1236" /incds=1 /nref=2 /ntot=2 /MaxReadThrough="-0.14995" /MaxDrop="4.86715" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2052880..2052898) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-10" upshifts complement(2052889) /Source="Nicolas_upshifts" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="upshifts" promotor_-35 complement(2052915..2052920) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-35" promotor_-35 2052960..2052963 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2052978..2052997 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2052987 /Source="Nicolas_upshifts" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="upshifts" CDS 2053021..2053227 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390253.1" /db_xref="EnsemblGenomes-Gn:BSU23720" /db_xref="EnsemblGenomes-Tr:CAB14304" /db_xref="InterPro:IPR025546" /db_xref="SubtiList:BG13774" /db_xref="UniProtKB/Swiss-Prot:O32014" /translation="MEKFVEKMLGQALRQYGRNVAIDPLSPYEKQSLKAALQERRNEE PDEDLHAHIEDIIYDYVTNQGLFS*" /label="yqzH CDS" gene 2053021..2053227 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /label="yqzH gene" promotor_-35 2053710..2053713 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2053728..2053747 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2053744 /Source="Nicolas_upshifts" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="upshifts" CDS 2053776..2055008 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390254.2" /db_xref="EnsemblGenomes-Gn:BSU23730" /db_xref="EnsemblGenomes-Tr:CAB14305" /db_xref="GOA:P54559" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11751" /db_xref="UniProtKB/Swiss-Prot:P54559" /translation="MKKWKDIHPISWTIIIGTIFGRMATSMSIPFLAIYLTAVQGASA SYAGLVIAASSSVGILASFYGGYISDKFGRKNMMLVSIFGWMLVFAGFAAASNLWVFF VVNALNGLCKSLFEPASKALLSDMTEEKTRLLVFNLRYAAINIGVVFGPVLGLYFGSS QSTTPFLVPAVIYGLYGIVLALQFKKHPSLSAPAQSRNMSVREAFMVTQKDYLFTIAL VGITLCTFGYSQFSSTFPQYMAQNPLIGNGTKLYGLMLTLNAIVVLATQFPIVHFAKR FSPLCSLMLGNVMVSISMAIFTVSHGVPSIVMIVITFTIGEVLLFSMMDLYVDQIAKP GLKGTYFGAIGFSQLGNVIGPWVGGICIDLFGAGRPIYIFSVLSGITLLGLPFLAFAY RQMKMETTKHRSRLEKPL*" /label="yqjV CDS" gene 2053776..2055008 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /label="yqjV gene" CDS 2054855..2055217 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390255.2" /db_xref="EnsemblGenomes-Gn:BSU23740" /db_xref="EnsemblGenomes-Tr:CAB14306" /db_xref="GOA:P54558" /db_xref="SubtiList:BG11750" /db_xref="UniProtKB/Swiss-Prot:P54558" /translation="MYRPVWRWPADLYFFCPERHYPARPAIFSVRLSANENGDHKTPF PSGKAALNKKRKRMNLSRKHEVKNMNIGDVMFQLFVFIIFAAVVFAAVTGFKYAKNRK AQLDRIEKKLNSLSEDHD*" /label="yqjU CDS" gene 2054855..2055217 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /label="yqjU gene" S_feature complement(2055034..2055213) /Source="Nicolas_S_feature" /locus_tag="new_2467979_2468158_c" /HighExp="Sw, BC, C90, C30, M0t90, BI, Lbtran, Lbstat, M40t45, G135" /AntisenseName="yqjU" /AntisenseCor="-0.38632421151235602" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S899" downshifts complement(2055067) /Source="Nicolas_upshifts" /id="D1237" /incds=0 /nref=59 /ntot=226 /MaxReadThrough="1.66997" /MaxDrop="4.81479" /score="21.7095422" /energy="-11.4" /TU="NA" /idTUdmin="U1858" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2055214..2055600) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390256.1" /db_xref="EnsemblGenomes-Gn:BSU23750" /db_xref="EnsemblGenomes-Tr:CAB14307" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11749" /db_xref="UniProtKB/Swiss-Prot:P54557" /translation="MHHIELYVSDLEASRRFWGWFLKELGYKEYQKWSSGISWKKDRF YLVIVQAKEPFLEPEYHRCRVGLNHLAFHAESKLQVDQMTEKLTAKGYRVLYRDRHPF AGGDGHYAVFCEDPDRIKVELVAPSC*" /label="yqjT CDS" gene complement(2055214..2055600) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /label="yqjT gene" CDS complement(2055604..2056563) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328157, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328157, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase" /protein_id="NP_390257.2" /db_xref="EnsemblGenomes-Gn:BSU23760" /db_xref="EnsemblGenomes-Tr:CAB14308" /db_xref="GOA:P54556" /db_xref="InterPro:IPR004566" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11748" /db_xref="UniProtKB/Swiss-Prot:P54556" /translation="MKNKELNLHTLYTQHNRESWSGFGGHLSIAVSEEEAKAVEGLND YLSVEEVETIYIPLVRLLHLHVKSAAERNKHVNVFLKHPHSAKIPFIIGIAGSVAVGK STTARILQKLLSRLPDRPKVSLITTDGFLFPTAELKKKNMMSRKGFPESYDVKALLEF LNDLKSGKDSVKAPVYSHLTYDREEGVFEVVEQADIVIIEGINVLQSPTLEDDRENPR IFVSDFFDFSIYVDAEESRIFTWYLERFRLLRETAFQNPDSYFHKFKDLSDQEADEMA ASIWESVNRPNLYENILPTKFRSDLILRKGDGHKVEEVLVRRV*" /label="coaA CDS" gene complement(2055604..2056563) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /label="coaA gene" S_feature complement(2056564..2056634) /Source="Nicolas_S_feature" /locus_tag="new_2469509_2469579_c" /HighExp="LBGtran, dia15, Diami, C90, H2O2, M0t45, G135, Lbtran, HiTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S900" CDS complement(2056635..2057981) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /EC_number="4.3.1.18" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-serine ammonia-lyase" /protein_id="NP_390258.2" /db_xref="EnsemblGenomes-Gn:BSU23770" /db_xref="EnsemblGenomes-Tr:CAB14309" /db_xref="GOA:P54555" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011780" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG11747" /db_xref="UniProtKB/Swiss-Prot:P54555" /translation="MSVHSEVLHALLKDPFIQKLIDAEPVFWANSGKKEGPLPRADEW ATEIAEAEKRMQRFAPYIAEVFPETKGAKGIIESPLFEVQHMKGKLEAAYQQPFPGRW LLKCDHELPISGSIKARGGIYEVLKYAENLALQEGMLQETDDYRILQEERFTGFFSRY SIAVGSTGNLGLSIGIIGAALGFRVTVHMSADAKQWKKDLLRQKGVTVMEYETDYSEA VNEGRRQAEQDPFCYFIDDEHSRQLFLGYAVAASRLKTQLDCMNIKPSLETPLFVYLP CGVGGGPGGVAFGLKLLYGDDVHVFFAEPTHSPCMLLGLYSGLHEKISVQDIGLDNQT AADGLAVGRPSGFVGKLIEPLLSGCYTVEDNTLYTLLHMLAVSEDKYLEPSALAGMFG PVQLFSTEEGRRYAQKYKMEHAVHVVWGTGGSMVPKDEMAAYNRIGADLLKKRNEK*" /label="dsdA CDS" gene complement(2056635..2057981) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /label="dsdA gene" S_feature complement(2057982..2058056) /Source="Nicolas_S_feature" /locus_tag="new_2470927_2471001_c" /HighExp="C90, LBGtran, Diami, dia15, H2O2, dia5, G150, MG 15, GM-0.2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S901" CDS complement(2058057..2058836) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metabolite dehydrogenase, NAD-binding" /protein_id="NP_390259.1" /db_xref="EnsemblGenomes-Gn:BSU23780" /db_xref="EnsemblGenomes-Tr:CAB14310" /db_xref="GOA:P54554" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11746" /db_xref="UniProtKB/Swiss-Prot:P54554" /translation="MKHIAGKRIWITGASGGLGERIAYLCAAEGAHVLLSARREDRLI EIKRKITEEWSGQCEIFPLDVGRLEDIARVRDQIGSIDVLINNAGFGIFETVLDSTLD DMKAMFDVNVFGLIACTKAVLPQMLEQKKGHIINIASQAGKIATPKSSLYSATKHAVL GYSNALRMELSGTGIYVTTVNPGPIQTDFFSIADKGGDYAKNVGRWMLDPDDVAAQIT AAIFTKKREINLPRLMNAGTKLYQLFPALVEKLAGRALMKK*" /label="yqjQ CDS" gene complement(2058057..2058836) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /label="yqjQ gene" CDS complement(2058842..2059801) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390260.1" /db_xref="EnsemblGenomes-Gn:BSU23790" /db_xref="EnsemblGenomes-Tr:CAB14311" /db_xref="GOA:P54553" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11745" /db_xref="UniProtKB/Swiss-Prot:P54553" /translation="MTTEDVIAIRVPTPFAVGDVIVYLVKGDALTLIDAGPNTKEAAR ALQEQLAAVNVKLSDIEQVVLTHHHADHAGLLDVFSDEIEVIGHTFNEPYISQNQAFM DWQKRFFQKLLPELGVPFDTGKAEKLIRSAYAFSCTRSLTKSIREGMGIDGLEGWSVL EMPGHAESHIVLFHEKSGRMLGGDLLLANSSSNPILEAPKAGDVRSKPLVDYQRSLRR LSQLDPTIVFPGHGEPITSVQALIEKRFDKQRNRTEDVRRMLDEKPMTAFQVCQQLFP AVYEKELFLTMSETAGHLDVLEAEEAITSYWEGNTVYFKTMKR*" /label="yqjP CDS" gene complement(2058842..2059801) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /label="yqjP gene" promotor_-10 complement(2059823..2059842) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2059842) /Source="Nicolas_upshifts" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2059857..2059864) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2059898..2059905 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2059919..2060205 /Source="Nicolas_S_feature" /locus_tag="new_2472864_2473150" /HighExp="Diami, C90, BC, Paraq, G180, GM 15, Oxctl, S7, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S902" upshifts 2059919 /Source="Nicolas_upshifts" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2059921..2059940 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2059935..2060180 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /product="proline T-box riboswitch" /experiment="publication(s) with functional evidences, PMID:21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21233158" /label="pswI RNA" gene 2059935..2060180 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /label="pswI gene" CDS 2060206..2061042 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21233158, 28752945, 28824574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21233158, 28752945, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase (NADP-dependent, weak activity)" /protein_id="NP_390261.1" /db_xref="EnsemblGenomes-Gn:BSU23800" /db_xref="EnsemblGenomes-Tr:CAB14312" /db_xref="GOA:P54552" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11744" /db_xref="UniProtKB/Swiss-Prot:P54552" /translation="MKKIGFVGAGSMAEAMINGILQSGITKPEHIYITNRSNDERLIE LKETYSVRPCRDKNEFFTHTDIIILAFKPKDAAESIDSIRPYIKDQLVISVLAGLTIE TIQHYFGRKLAVIRVMPNTSAAIRKSATGFSVSTEASKNDIIAAKALLETIGDATLVE ERHLDAVTAIAGSGPAYVYRYIEAMEKAAQKVGLDKETAKALILQTMAGATDMLLQSG KQPEKLRKEITSPGGTTEAGLRALQDSRFEEAIIHCIEETAKRSAEIKEQFAGAALER HS*" /label="proI CDS" gene 2060206..2061042 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /label="proI gene" downshifts 2061040 /Source="Nicolas_upshifts" /id="D1238" /incds=0 /nref=29 /ntot=190 /MaxReadThrough="0.55696" /MaxDrop="3.78131" /score="36.2472665" /energy="-12" /TU="NA" /idTUdmin="U1859" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2061083..2062726) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase" /protein_id="NP_390262.2" /db_xref="EnsemblGenomes-Gn:BSU23810" /db_xref="EnsemblGenomes-Tr:CAB14313" /db_xref="GOA:P54551" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG11743" /db_xref="UniProtKB/Swiss-Prot:P54551" /translation="MNWQTKDELLALLTSLVQYESITGSKGEVALAEYLYFILKDKPY FQKHPDDVTLHPMDDGRSFLTALVKKKNVKKTVLLLSHFDVVDIEDYGEFKHMACKPA ELLSSFLEKKELLPERVRRDAESGDWLFGRGTMDMKAGLCIQLSMLERAMNGHFEGNL LLITVPDEEVNSRGMIEAVPALKEMEKKHDITLTACLNAEPMFEKFPGDQQQYFYTGS IGKVLAGFFCKGIETHVGEPFSGLNANLMVSEINRLLELNADYCEKVDGEVTPPPVNL MQKDLKEAYSVQTPHTAVTLFNVLSMKRSASELHQMLLKTAEQAAEEIMSNVRKKTQD FQQFEPFQPIERDVTVLTFDELVSRAKKRAGISETERALNYAFANRGELGDRDFSTKI VSELASLCKEDAPLIVLFYSPPLYPAVSSKDDQLIRNTADQIKHYAAERYGIALREVQ YFPGLSDLSYLQLEKQEVDAYTSNMPLFNRGYSLPSGKNQALYVPVLNVGPAGKDPHK WTERLYMPYSFEVLPDLLSFTISALLKQSESAGQLLREK*" /label="yqjN CDS" gene complement(2061083..2062726) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /label="yqjN gene" downshifts complement(2061095) /Source="Nicolas_upshifts" /id="D1239" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="2.2598" /MaxDrop="2.55609" /score="14.9380989" /energy="-12" /TU="NA" /idTUdmin="U1861" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2062744..2062750 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2062757 /Source="Nicolas_upshifts" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2062764..2062775 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(2062782..2062801) /Source="Nicolas_upshift_promotors" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2062787) /Source="Nicolas_upshifts" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2062833..2062840 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2062854..2062873 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2062856 /Source="Nicolas_upshifts" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="upshifts" CDS 2062898..2063914 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /EC_number="1.6.99.1" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12660247, 15249051, 15890652, 20011599, 20461254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12660247, 15249051, 15890652, 20011599, 20461254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent flavin oxidoreductase (acting oncinnamaldehyde-related compounds)" /protein_id="NP_390263.1" /db_xref="EnsemblGenomes-Gn:BSU23820" /db_xref="EnsemblGenomes-Tr:CAB14314" /db_xref="GOA:P54550" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023663" /db_xref="PDB:1Z41" /db_xref="PDB:1Z42" /db_xref="PDB:1Z44" /db_xref="PDB:1Z48" /db_xref="SubtiList:BG11742" /db_xref="UniProtKB/Swiss-Prot:P54550" /translation="MARKLFTPITIKDMTLKNRIVMSPMCMYSSHEKDGKLTPFHMAH YISRAIGQVGLIIVEASAVNPQGRITDQDLGIWSDEHIEGFAKLTEQVKEQGSKIGIQ LAHAGRKAELEGDIFAPSAIAFDEQSATPVEMSAEKVKETVQEFKQAAARAKEAGFDV IEIHAAHGYLIHEFLSPLSNHRTDEYGGSPENRYRFLREIIDEVKQVWDGPLFVRVSA SDYTDKGLDIADHIGFAKWMKEQGVDLIDCSSGALVHADINVFPGYQVSFAEKIREQA DMATGAVGMITDGSMAEEILQNGRADLIFIGRELLRDPFFARTAAKQLNTEIPAPVQY ERGW*" /label="yqjM CDS" gene 2062898..2063914 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /label="yqjM gene" downshifts 2063901 /Source="Nicolas_upshifts" /id="D1240" /incds=0 /nref=42 /ntot=157 /MaxReadThrough="2.79686" /MaxDrop="5.04803" /score="39.119339" /energy="-12.8" /TU="U1862" /idTUdmin="U1862" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 2063963..2063972 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2063985..2064000 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2063989 /Source="Nicolas_upshifts" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="upshifts" CDS 2064024..2064785 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390264.1" /db_xref="EnsemblGenomes-Gn:BSU23830" /db_xref="EnsemblGenomes-Tr:CAB14315" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11741" /db_xref="UniProtKB/Swiss-Prot:P54549" /translation="MKSAWMEKTYTIDGCAFHTQHRKGSSGVTIVFEAGYGTSSETWK PLMADIDDEFGIFTYDRAGIGKSGQSRAKRTADQQVKELESLLKAADVKPPYLAVSHS YGAVITGLWACKNKHDIIGMVLLDPALGDCASFTFIPEEMHKSHTRKMMLEGTHAEFS KSLQELKKRQVHLGNMPLLVLSSGERTEKFAAEQEWQNLHSSILSLSNQSGWIQAKNS SHNIHHDEPHIVHLAIYDVWCAACQQAAPLYQAVN*" /label="yqjL CDS" gene 2064024..2064785 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /label="yqjL gene" downshifts 2064693 /Source="Nicolas_upshifts" /id="D1241" /incds=1 /nref=21 /ntot=204 /MaxReadThrough="3.34804" /MaxDrop="3.21955" /score="0.451826768" /energy="-11.2" /TU="U1863" /idTUdmin="U1862" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts 2064781 /Source="Nicolas_upshifts" /id="D1242" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="1.34151" /MaxDrop="3.85711" /score="0.451826768" /energy="-11.2" /TU="NA" /idTUdmin="U1863" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2064813..2065013) /Source="Nicolas_S_feature" /locus_tag="new_2477758_2477958_c" /HighExp="B60, S5, Etha, S4, B36, BMM, Heat, S3, S2, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.21631400000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S903" CDS complement(2064829..2064954) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33* pseudogene" /translation="CTETGDRNYITTKNKRTNPDRLELKKYSPRLKKYTLHRETK*" /label="rpmGCc CDS" gene complement(2064829..2064954) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /pseudo /label="rpmGCc gene" downshifts complement(2064856) /Source="Nicolas_upshifts" /id="D1243" /incds=0 /nref=187 /ntot=264 /MaxReadThrough="3.91531" /MaxDrop="7.65732" /score="5.23287853" /energy="-8.8" /TU="U1864" /idTUdmin="U1865" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2064947..2064979) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 19648245, 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33C pseudogene" /db_xref="PSEUDO:CCQ48601.1" /translation="MRVNVTLALH*" /label="rpmGCn CDS" gene complement(2064947..2064979) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /pseudo /label="rpmGCn gene" promotor_-10 complement(2065007..2065026) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2065013) /Source="Nicolas_upshifts" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2065039..2065046) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2065061..2065984) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /EC_number="3.1.26.11" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 12941704, 16336119, 17005971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12941704, 16336119, 17005971; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease Z" /protein_id="NP_390265.1" /db_xref="EnsemblGenomes-Gn:BSU23840" /db_xref="EnsemblGenomes-Tr:CAB14316" /db_xref="GOA:P54548" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR013471" /db_xref="InterPro:IPR036866" /db_xref="PDB:1Y44" /db_xref="PDB:2FK6" /db_xref="PDB:4GCW" /db_xref="SubtiList:BG11740" /db_xref="UniProtKB/Swiss-Prot:P54548" /translation="MELLFLGTGAGIPAKARNVTSVALKLLEERRSVWLFDCGEATQH QILHTTIKPRKIEKIFITHMHGDHVYGLPGLLGSRSFQGGEDELTVYGPKGIKAFIET SLAVTKTHLTYPLAIQEIEEGIVFEDDQFIVTAVSVIHGVEAFGYRVQEKDVPGSLKA DVLKEMNIPPGPVYQKIKKGETVTLEDGRIINGNDFLEPPKKGRSVVFSGDTRVSDKL KELARDCDVLVHEATFAKEDRKLAYDYYHSTTEQAAVTAKEARAKQLILTHISARYQG DASLELQKEAVDVFPNSVAAYDFLEVNVPRG*" /label="rnz CDS" gene complement(2065061..2065984) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /label="rnz gene" promotor_-10 complement(2066010..2066029) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2066023) /Source="Nicolas_upshifts" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2066043..2066048) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2066122..2066129 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2066143..2066162 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2066145..2066210 /Source="Nicolas_S_feature" /locus_tag="new_2479090_2479155" /HighExp="dia5, C90, MG 5, Lbexp, MG t5, MG 45, M9-exp, GM 90, GM 120, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S904" upshifts 2066145 /Source="Nicolas_upshifts" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="upshifts" CDS 2066211..2067680 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /EC_number="1.1.1.49" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1704005, 19779711, 26129872" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1704005, 19779711, 26129872; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate 1-dehydrogenase (NADP-dependent)" /protein_id="NP_390266.2" /db_xref="EnsemblGenomes-Gn:BSU23850" /db_xref="EnsemblGenomes-Tr:CAB14317" /db_xref="GOA:P54547" /db_xref="InterPro:IPR001282" /db_xref="InterPro:IPR019796" /db_xref="InterPro:IPR022674" /db_xref="InterPro:IPR022675" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11739" /db_xref="UniProtKB/Swiss-Prot:P54547" /translation="MKTNQQPKAVIVIFGATGDLAKRKLYPSIHRLYQNGQIGEEFAV VGVGRRPWSNEDLRQTVKTSISSSADKHIDDFTSHFYYHPFDVTNPGSYQELNVLLNQ LEDTYQIPNNRMFYLAMAPEFFGTIAKTLKSEGVTATTGWSRLVIEKPFGHDLPSAQA LNKEIREAFTEDQIYRIDHYLGKQMVQNIEVIRFANAIFEPLWTNRYISNIQITSSES LGVEDRARYYEKSGALRDMVQNHIMQMVALLAMEPPIKLNTEEIRSEKVKVLRALRPI AKDEVDEYFVRGQYHAGEIDGVPVPAYTDEDNVAPDSNTETFVAGKLLIDNFRWAGVP FYIRTGKRMKEKSTKIVVQFKDIPMNLYYGNENNMNPNLLVIHIQPDEGITLYLNAKK LGGAAHAQPIKLDYCSNCNDELNTPEAYEKLIHDCLLGDATNFAHWDEVALSWSFVDS ISETWAANKTLSPNYESGSMGPKESDDLLVKDGLHWWNI*" /label="zwf CDS" gene 2066211..2067680 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /label="zwf gene" downshifts 2067663 /Source="Nicolas_upshifts" /id="D1244" /incds=0 /nref=206 /ntot=286 /MaxReadThrough="3.46838" /MaxDrop="7.76173" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-90" /isTUend="FALSE" /label="downshifts" terminator 2067688..2067727 /created_by="User" /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" /label="Delta6_zwf-T-gndA_Terminator" Polymorphism join(2067700,2067703) /Source="geneious" /ID="SNP_BsDelta6_2480646_2480647" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=2 /Amino_Acid_Change /CDS_Position /Change="TA -> AT" /Codon_Change /Coverage=115 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="TA" /Variant_Nucleotides="AT" /Variant_P_Value=0 /Variant_Raw_Frequency=113 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(2067708,2067709) /Source="geneious" /ID="SNP_BsDelta6_2480654_2480654" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-T" /Codon_Change /Coverage=115 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides /Variant_P_Value="2.1e-279" /Variant_Raw_Frequency=113 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(2067720,2067721) /Source="geneious" /ID="SNP_BsDelta6_2480667_2480667" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-T" /Codon_Change /Coverage=116 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides /Variant_P_Value="2.9e-244" /Variant_Raw_Frequency=110 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" downshifts 2067729 /Source="Nicolas_upshifts" /id="D1245" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="2.5392" /MaxDrop="4.74183" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2067803..2069212) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /EC_number="1.1.1.44" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 15755726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 15755726; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP+-dependent 6-P-gluconate dehydrogenase" /protein_id="NP_390267.2" /db_xref="EnsemblGenomes-Gn:BSU23860" /db_xref="EnsemblGenomes-Tr:CAB14318" /db_xref="GOA:P80859" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11738" /db_xref="UniProtKB/Swiss-Prot:P80859" /translation="MSKQQIGVIGLAVMGKNLALNIESRGFSVSVYNRSSSKTEEFLQ EAKGKNVVGTYSIEEFVQSLETPRKILLMVKAGTATDATIQSLLPHLEKDDILIDGGN TYYKDTQRRNKELAESGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAIS AKVDGEPCTTYIGPDGAGHYVKMVHNGIEYGDMQLISESYFILKQVLGLSADELHEVF AEWNKGELDSYLIEITADIFTKKDEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVP LPIITESVFARFISAMKEERVKASGLLSGPEVKPVTENKEELIEAVRKALFMSKICSY AQGFAQMKAASEEYNWDLKYGEIAMIFRGGCIIRAAFLQKIKEAYDREPELDNLLLDS YFKNIVESYQGALRQVISLAVAQGVPVPSFSSALAYYDSYRTAVLPANLIQAQRDYFG AHTYERTDKEGIFHTEWMK*" /label="gndA CDS" gene complement(2067803..2069212) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /label="gndA gene" downshifts complement(2067820) /Source="Nicolas_upshifts" /id="D1246" /incds=0 /nref=220 /ntot=361 /MaxReadThrough="1.88983" /MaxDrop="8.82894" /score="24.3727084" /energy="-18" /TU="NA" /idTUdmin="U1867" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" downshifts complement(2067893) /Source="Nicolas_upshifts" /id="D1247" /incds=1 /nref=1 /ntot=36 /MaxReadThrough="8.40595" /MaxDrop="2.3555" /score="24.3727084" /energy="-18" /TU="U1867" /idTUdmin="U1867" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" misc_feature complement(2069276..2069294) /Source="Nicolas_upshift_promotors" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2069278) /Source="Nicolas_upshifts" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2069322..2070566) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /EC_number="2.7.7.7" /function="16.6: Maintain" /function="16.5: Explore" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-damage lesion bypass DNA polymerase" /protein_id="NP_390268.2" /db_xref="EnsemblGenomes-Gn:BSU23870" /db_xref="EnsemblGenomes-Tr:CAB14319" /db_xref="GOA:P54545" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017061" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR024728" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11737" /db_xref="UniProtKB/Swiss-Prot:P54545" /translation="MPGKSRIIFHIDMNSFYASVEMAYDPALRGKPVAVAGNVKERKG IVVTCSYEARARGVKTTMPVWQAKRHCPELIVLPPNFDRYRNSSRAMFTILREYTDLV EPVSIDEGYMDMTDTPYSSRALETAKEIQSRLQKELLLPSSIGIAPNKFLAKMASDMK KPLGITILRKRQVPDILWPLPVGEMHGVGKKTAEKLKGLGIHTIGELAAADEHSLKRL LGINGPRLKNKANGIHHAPVDPERIYEFKSVGNSSTLSHDSSDEEELLGVFRKLAASV SDRLQRKEVMASKLFIMIRYADWRTITRSTTLRNPIDQKNDILKEAEHLFFKHWNKNP VRLLGITGTDLVEKEQAYKQLDLFSFNEDAKDEPIQQMMEKLNKKYGTKLIRKGATLK KEESKTKGTSFNKDFFQDEKKS*" /label="polYA CDS" gene complement(2069322..2070566) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /label="polYA gene" S_feature complement(2070567..2070841) /Source="Nicolas_S_feature" /locus_tag="new_2483514_2483788_c" /HighExp="M40t90, Sw, M40t45, H2O2, C30, Cold, Etha, C90, Diami, BC" /AntisenseName="yqzJ" /AntisenseCor="0.48883700687558601" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S905" promotor_-35 2070587..2070594 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2070608..2070627 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2070608 /Source="Nicolas_upshifts" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="upshifts" CDS 2070639..2070926 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /experiment="publication(s) with functional evidences, PMID:19779460, 21383133, 22720735, 25313395, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19779460, 21383133, 22720735, 25313395, 25903689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of OxaAB translation" /protein_id="YP_054586.1" /db_xref="EnsemblGenomes-Gn:BSU23880" /db_xref="EnsemblGenomes-Tr:CAE01460" /db_xref="GOA:Q7WY64" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG14191" /db_xref="UniProtKB/Swiss-Prot:Q7WY64" /translation="MTMFVESINDVLFLVDFFTIILPALTAIGIAFLLRECRAGEQWK SKRTDEHQTVFHINRTDFLIIIYHRITTWIRKVFRMNSPVNDEEDAGSLLL*" /label="mifM CDS" gene 2070639..2070926 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /label="mifM gene" promotor_-10 complement(2070823..2070842) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-10" upshifts complement(2070843) /Source="Nicolas_upshifts" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="upshifts" promotor_-35 complement(2070858..2070861) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-35" CDS 2070957..2071784 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_390269.1" /db_xref="EnsemblGenomes-Gn:BSU23890" /db_xref="EnsemblGenomes-Tr:CAB14320" /db_xref="GOA:P54544" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG11736" /db_xref="UniProtKB/Swiss-Prot:P54544" /translation="MLKTYQKLLAMGIFLIVLCSGNAAFAATNQVGGLSNVGFFHDYL IEPFSALLKGVAGLFHGEYGLSIILVTIIVRIVVLPLFVNQFKKQRIFQEKMAVIKPQ VDSIQVKLKKTKDPEKQKELQMEMMKLYQEHNINPLAMGCLPMLIQSPIMIGLYYAIR STPEIASHSFLWFSLGQSDILMSLSAGIMYFVQAYIAQKLSAKYSAVPQNPAAQQSAK LMVFIFPVMMTIFSLNVPAALPLYWFTSGLFLTVQNIVLQMTHHKSKKTAALTESVK* " /label="oxaAB CDS" gene 2070957..2071784 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /label="oxaAB gene" downshifts 2071601 /Source="Nicolas_upshifts" /id="D1248" /incds=1 /nref=4 /ntot=125 /MaxReadThrough="5.05074" /MaxDrop="3.49092" /score="-5.67811369" /energy="-7.6" /TU="U1868" /idTUdmin="U1868" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 2071777 /Source="Nicolas_upshifts" /id="D1249" /incds=0 /nref=71 /ntot=229 /MaxReadThrough="1.09826" /MaxDrop="6.56698" /score="-5.67811369" /energy="-7.6" /TU="NA" /idTUdmin="U1868" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2071789..2072709) /Source="Nicolas_S_feature" /locus_tag="new_2484736_2485656_c" /HighExp="LoTm, B36, M0t90, M40t90, Lbstat, M9-stat, T1.30H, B60, LBGtran, BT" /AntisenseName="yqjF" /AntisenseCor="0.18628881890353799" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S906" downshifts complement(2071832) /Source="Nicolas_upshifts" /id="D1250" /incds=0 /nref=170 /ntot=248 /MaxReadThrough="0.24428" /MaxDrop="6.31082" /score="18.1943524" /energy="-12.4" /TU="NA" /idTUdmin="U1871" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2071902..2071908 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2071922..2071940 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2071931 /Source="Nicolas_upshifts" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="upshifts" CDS 2071964..2072692 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390270.3" /db_xref="EnsemblGenomes-Gn:BSU23900" /db_xref="EnsemblGenomes-Tr:CAB14321" /db_xref="InterPro:IPR018644" /db_xref="InterPro:IPR023375" /db_xref="SubtiList:BG11735" /db_xref="UniProtKB/Swiss-Prot:P54543" /translation="MTERFQQKNISVPDGIWIMRQTWNDVLFAHWPVDVSILRALVPS VLELDTYNGQAWISMLPFMLTNLRARYLPVIPGARAFPELNLRTYVTYKGKPGIYFFS LDADHRLAVLGARTFFHLPYFYADMKSEKNGDAIDYVSKRKNDKEAAFHAAYRPISAP FTAEKDSLDYWLTERYRLYTTYRNKLYYEDIHHHPWLLQNAEAEISVNTVTDAHGITL PESDPLLHYAKKQDVLFWPLRKWS*" /label="yqjF CDS" gene 2071964..2072692 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /label="yqjF gene" CDS complement(2072733..2073848) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase or deacylase" /protein_id="NP_390271.2" /db_xref="EnsemblGenomes-Gn:BSU23910" /db_xref="EnsemblGenomes-Tr:CAB14322" /db_xref="GOA:P54542" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR010162" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11734" /db_xref="UniProtKB/Swiss-Prot:P54542" /translation="MVNEKRLLEEFLELVQIDSETKHEAEICKVLKRKFSDLGVDVKE DDTMDITGHGAGNLICTLKGTKQTDTIYFTSHMDTVVPGNGVKPVVENGYVKTDGTTI LGADDKAGLAAMFEAIKVLKEENIEHGTIEFIITVGEESGLIGAKALDRSMITASYGY ALDSDGKVGNIIVAAPTQAKVRAAIFGKTAHAGVEPEKGISAITIASKAISKMPLGRI DEETTANIGRFEGGTQTNIVCDEVHILAEARSLVPEKMEAQVQKMKAAFEEAAADMGG RAEVEIEVMYPGFKYQDGDQVVEIAKKAAAKIGRPSELQTSGGGSDANVIAGHGIPTV NLAVGYEQIHTKNEKMPIEELVKTAEMVVAIIEEAAK*" /label="yqjE CDS" gene complement(2072733..2073848) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /label="yqjE gene" downshifts complement(2072754) /Source="Nicolas_upshifts" /id="D1251" /incds=0 /nref=23 /ntot=203 /MaxReadThrough="3.90071" /MaxDrop="3.95711" /score="11.6635037" /energy="-10.6" /TU="U1871" /idTUdmin="U1871" /TUdmin="-923" /isTUend="FALSE" /label="downshifts" CDS complement(2073866..2075389) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /EC_number="6.4.1.3" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative propionyl-CoA carboxylase beta chain" /protein_id="NP_390272.2" /db_xref="EnsemblGenomes-Gn:BSU23920" /db_xref="EnsemblGenomes-Tr:CAB14323" /db_xref="GOA:P54541" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG11733" /db_xref="UniProtKB/Swiss-Prot:P54541" /translation="MNEHMDHFYTKRKQAEEGGGREKLAQQRQKGKLTARERIIFLLD QDSFIELHPFMESQVLTREQRMLGDGVVTGYGTIDGRSVYVFAQDFTVYGGALGETHA RKICALMDLAAKNKAPIIGLNDSGGARIQEGVLSLDGYGHIFYRNVLYSGVIPQISVI LGPCAGGAVYSPALTDFIFMAEQTGRMFITGPKVIEKVTGEQVDAESLGGAGIHNAVS GNAHFSGHTEKEVLTGVRKLLSYLPLNGRTTEPKPEKEASRPLLNRLVPADTTKPYDV RKVIRELADPQSFFEIQPFFAKNIVIGFARLGEKAIGIVASQPKHLAGSLTIDAADKA ARFIRFCDAFDIPLLTVEDVPGFLPGIQQEHNGIIRHGAKLLFAYAEATVPKVTLIIR KAYGGAYVAMNSKAIGADLVFAWPNAEIAVMGPEGAASILYEKEIKASADPQKTKREK TAEYKKQNAGPYKAAACGMVDDIILPEESRGRLIQAFHMLTHKTEERPKKKHGNIPL* " /label="yqjD CDS" gene complement(2073866..2075389) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /label="yqjD gene" promotor_-10 complement(2074972..2074991) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2074994) /Source="Nicolas_upshifts" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2075006..2075010) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2075382..2075804) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /EC_number="5.1.99.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methylmalonyl-CoA epimerase" /protein_id="NP_390273.2" /db_xref="EnsemblGenomes-Gn:BSU23930" /db_xref="EnsemblGenomes-Tr:CAB14324" /db_xref="GOA:P54540" /db_xref="InterPro:IPR017515" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11732" /db_xref="UniProtKB/Swiss-Prot:P54540" /translation="MNRLDHIGIAVFSIKDARSFYENVLGLAFLHQETVEEQKVNVAF FQAGSVKLELIEPLTADSPVHLFLEKKGQGLHHIAFLCNCLSEQLQALSDQHVQLIDR FPRQGANGKKIAFISPRETNGVLVELCEPKGDQHNEHE*" /label="yqjC CDS" gene complement(2075382..2075804) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /label="yqjC gene" promotor_-35 2075833..2075840 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2075854..2075873 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2075868..2076021 /Source="Nicolas_S_feature" /locus_tag="new_2488815_2488968" /HighExp="LPhT, Etha, dia15, Salt, M9-stat, LBGstat, Heat, BC, T-0.40H, HiOs" /AntisenseName="yqjB" /AntisenseCor="-0.57221813594264503" /AntisenseRegPval="-24.1" /CDS_PredictionProba="0.99822200000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S907" upshifts 2075868 /Source="Nicolas_upshifts" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="upshifts" downshifts 2075978 /Source="Nicolas_upshifts" /id="D1252" /incds=0 /nref=1 /ntot=140 /MaxReadThrough="3.88708" /MaxDrop="3.25163" /score="3.10927996" /energy="-7" /TU="U1872" /idTUdmin="U1872" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" CDS complement(2076006..2076536) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /EC_number="2.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative L,D-transpeptidase" /protein_id="NP_390274.1" /db_xref="EnsemblGenomes-Gn:BSU23940" /db_xref="EnsemblGenomes-Tr:CAB14325" /db_xref="GOA:P54539" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG11731" /db_xref="UniProtKB/Swiss-Prot:P54539" /translation="MRFFLCSIFMMISPIWPLGENPLPGDPYVIVNKRTNELAVILDN KVEGVYSVATGKTDDLTPEGEFSVTVKAENPYYRKKNIEGGSPDNPLGARWIGFDAKG TDGRIYGIHGTNREESVGKFVSNGCIRMHNDEVVHLFQTIPVGTRVLITDDNRSFEEI AIEHKALIKKQDIPIE*" /label="yqjB CDS" gene complement(2076006..2076536) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /label="yqjB gene" S_feature 2076023..2076658 /Source="Nicolas_S_feature" /locus_tag="new_2488970_2489605" /HighExp="LPhT, H2O2, BC, Salt, dia15, M9-stat, Heat, LBGstat, T5.0H, Etha" /AntisenseName="yqjB" /AntisenseCor="-0.31126010332536502" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S908" promotor_-10 complement(2076553..2076564) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2076560) /Source="Nicolas_upshifts" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2076579..2076585) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2076588..2077556) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390275.2" /db_xref="EnsemblGenomes-Gn:BSU23950" /db_xref="EnsemblGenomes-Tr:CAB14326" /db_xref="GOA:P54538" /db_xref="InterPro:IPR010343" /db_xref="InterPro:IPR021062" /db_xref="SubtiList:BG11730" /db_xref="UniProtKB/Swiss-Prot:P54538" /translation="MFKIGYRTIKTALGTALAIYISQLLHLQNFASAGIITILCIQIT QKRSLQASWARFSACCLAIAFSYLFFELIGYHPFVIGALLLIFIPITVLLKINEGIVT SSVIILHLYMSGGITPTFIWNEVQLITVGIGVALLMNLYMPSLDRKLIAYRKKIEDNF AVIFAEIERYLLTGEQDWSGKEIPETHQLITEAKNLAYRDVQNHILRYENLHYHYFKM REKQFEIIERLLPKVTSISITVDQGKMIAEFIHDLREAIHPGNTAYKFLKRLADMRKE FEEMPLPATREEFEARAALFHLLGEMEQYLVIKSYFKGIKAQKSLG*" /label="yqjA CDS" gene complement(2076588..2077556) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /label="yqjA gene" downshifts complement(2076604) /Source="Nicolas_upshifts" /id="D1253" /incds=0 /nref=79 /ntot=223 /MaxReadThrough="2.22356" /MaxDrop="3.94894" /score="1.98299685" /energy="-14.1" /TU="NA" /idTUdmin="U1874" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2077627..2078349) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (ATP-binding protein)" /protein_id="NP_390276.1" /db_xref="EnsemblGenomes-Gn:BSU23960" /db_xref="EnsemblGenomes-Tr:CAB14327" /db_xref="GOA:P54537" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11729" /db_xref="UniProtKB/Swiss-Prot:P54537" /translation="MIKVEKLSKSFGKHEVLKNISTTIAEGEVVAVIGPSGSGKSTFL RCLNLLEKPNGGTITIKDTEITKPKTNTLKVRENIGMVFQHFHLFPHKTVLENIMYAP VNVKKESKQAAQEKAEDLLRKVGLFEKRNDYPNRLSGGQKQRVAIARALAMNPDIMLF DEPTSALDPEMVKEVLQVMKELVETGMTMVIVTHEMGFAKEVADRVLFMDQGMIVEDG NPKEFFMSPKSKRAQDFLEKIL*" /label="artR CDS" gene complement(2077627..2078349) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /label="artR gene" downshifts complement(2077638) /Source="Nicolas_upshifts" /id="D1254" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="4.81216" /MaxDrop="4.0342" /score="0.346345754" /energy="-7" /TU="U1874" /idTUdmin="U1874" /TUdmin="-1034" /isTUend="FALSE" /label="downshifts" CDS complement(2078342..2079001) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (permease)" /protein_id="NP_390277.1" /db_xref="EnsemblGenomes-Gn:BSU23970" /db_xref="EnsemblGenomes-Tr:CAB14328" /db_xref="GOA:P54536" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11728" /db_xref="UniProtKB/Swiss-Prot:P54536" /translation="MNLDFSATIPQIPFILEGLAITLKIVVVSAIIGLILGIVLSLCK ISTFRPFIWIADFYTSVFRGTPLVLQLMIVYFGLPQLLGFQIDQFWAAVVALSLNSAA YVSEIIRAGINAIDKGQKEAAVALGVPYGKMMKDLLLPQAFKNISPAIVNELITLTKE SAIVTVIGLGDVMRRAYQAGAATYNYLEPLIIAGLIYYVLVLILTFIGKAVERKLKSN D*" /label="artQ CDS" gene complement(2078342..2079001) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /label="artQ gene" S_feature complement(2079002..2079081) /Source="Nicolas_S_feature" /locus_tag="new_2491949_2492028_c" /HighExp="S1, S2, ferm, MG 15, Fru, Glu, BMM, S3, UNK1, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S909" CDS complement(2079082..2079849) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter binding lipoprotein" /protein_id="NP_390278.1" /db_xref="EnsemblGenomes-Gn:BSU23980" /db_xref="EnsemblGenomes-Tr:CAB14329" /db_xref="GOA:P54535" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11727" /db_xref="UniProtKB/Swiss-Prot:P54535" /translation="MKKWLLLLVAACITFALTACGSSNSGSESGKKKLIMGTSADYKP FEYKEGDNIVGFDVELAKALAKKAGYEIEVQDMDFNSLITALKSKQVDLVLSGMTPTP ERKKQVDFSDVYYTANHMIVSKKDSGIQSLKDLKGKTVGVQLGSIQEEKGKELSPEYG FKTEDRNRISDLVQEIKSDRFDAAIIEDIVAEGYFKSNDDLQGFVIPDAKAEEAGSAI AFRKDSELTDKFNKALKEMEDNGELEKLKKKWFTGEK*" /label="artP CDS" gene complement(2079082..2079849) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /label="artP gene" promotor_-10 complement(2079899..2079918) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2079914) /Source="Nicolas_upshifts" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2079933..2079940) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2080117..2080554) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /experiment="publication(s) with functional evidences, PMID:21749987, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21749987, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin B (de-bacillithiolation)" /protein_id="NP_390279.1" /db_xref="EnsemblGenomes-Gn:BSU23990" /db_xref="EnsemblGenomes-Tr:CAB14330" /db_xref="InterPro:IPR009474" /db_xref="SubtiList:BG11726" /db_xref="UniProtKB/Swiss-Prot:P54534" /translation="MNMDFNLFMNDIVRQARQEITAAGYTELKTAEEVDEALTKKGTT LVMVNSVCGCAGGIARPAAYHSVHYDKRPDQLVTVFAGQDKEATARARDYFEGYPPSS PSFAILKDGKIMKMVERHEIEGHEPMAVVAKLQEAFEEYCEEV*" /label="brxB CDS" gene complement(2080117..2080554) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /label="brxB gene" downshifts complement(2080126) /Source="Nicolas_upshifts" /id="D1255" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="3.9242" /MaxDrop="7.06654" /score="21.489397" /energy="-11.8" /TU="U1875" /idTUdmin="U1875" /TUdmin="-200" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2080578..2080597) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-10" upshifts complement(2080599) /Source="Nicolas_upshifts" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="upshifts" promotor_-35 complement(2080612..2080619) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-35" promotor_-35 2080652..2080658 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2080671 /Source="Nicolas_upshifts" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2080673..2080691 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2080715..2081608 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /EC_number="2.7.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7961792, 8098708, 10220166, 17114254, 17535816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipid kinase BmrU" /protein_id="NP_390280.2" /db_xref="EnsemblGenomes-Gn:BSU24000" /db_xref="EnsemblGenomes-Tr:CAB14331" /db_xref="GOA:P39074" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG10302" /db_xref="UniProtKB/Swiss-Prot:P39074" /translation="MSHRKALLIHNGNAGNKNIEKALGAVVPVLSHHLDEVIIKQTKK KDDAYHFCRSIDDSVDTVFILGGDGTIHQCINAISALERKPAVGILPGGTCNDFSRVL GIPQNLAKAAEALMAGKKTSVDVCQMNDRYFLNFWGIGLIAETSNQINETEKALLGKI SYFTSALRTVSSAASFPMTLKIDGEEIKEEAVMLLVMNGQYIGTNRIPLPDASIEDGL LDVLICRNTNLTALRELMSMEQGSIDRFTGELSYVQASRIEIETDTAKKADMDGEVYT HTPAVIQVLPQHIDMLVPANE*" /label="bmrU CDS" gene 2080715..2081608 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /label="bmrU gene" promotor_-35 2081641..2081648 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2081664..2081683 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2081672 /Source="Nicolas_upshifts" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="upshifts" CDS 2081709..2082878 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10200972, 10961951, 11321573, 15849754, 16850406, 25756668" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 10961951, 11321573, 15849754, 16850406, 25756668; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_390281.2" /db_xref="EnsemblGenomes-Gn:BSU24010" /db_xref="EnsemblGenomes-Tr:CAB14332" /db_xref="GOA:P33449" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10303" /db_xref="UniProtKB/Swiss-Prot:P33449" /translation="MEKKNITLTILLTNLFIAFLGIGLVIPVTPTIMNELHLSGTAVG YMVACFAITQLIVSPIAGRWVDRFGRKIMIVIGLLFFSVSEFLFGIGKTVEMLFISRM LGGISAAFIMPGVTAFIADITTIKTRPKALGYMSAAISTGFIIGPGIGGFLAEVHSRL PFFFAAAFALLAAILSILTLREPERNPENQEIKGQKTGFKRIFAPMYFIAFLIILISS FGLASFESLFALFVDHKFGFTASDIAIMITGGAIVGAITQVVLFDRFTRWFGEIHLIR YSLILSTSLVFLLTTVHSYVAILLVTVTVFVGFDLMRPAVTTYLSKIAGNEQGFAGGM NSMFTSIGNVFGPIIGGMLFDIDVNYPFYFATVTLAIGIALTIAWKAPAHLKAST*" /label="bmr CDS" gene 2081709..2082878 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /label="bmr gene" downshifts 2082861 /Source="Nicolas_upshifts" /id="D1256" /incds=0 /nref=6 /ntot=31 /MaxReadThrough="4.82186" /MaxDrop="5.02667" /score="-1.94257488" /energy="-18" /TU="U1876,U1877" /idTUdmin="U1876" /TUdmin="-924" /isTUend="FALSE" /label="downshifts" CDS 2082951..2083787 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11201751, 11839496, 12682015, 14985361, 18658145, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11201751, 11839496, 12682015, 14985361, 18658145, 21690368; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family)" /protein_id="NP_390282.2" /db_xref="EnsemblGenomes-Gn:BSU24020" /db_xref="EnsemblGenomes-Tr:CAB14333" /db_xref="GOA:P39075" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="PDB:1BOW" /db_xref="PDB:1EXI" /db_xref="PDB:1EXJ" /db_xref="PDB:1R8E" /db_xref="PDB:2BOW" /db_xref="PDB:3D6Y" /db_xref="PDB:3D6Z" /db_xref="PDB:3D70" /db_xref="PDB:3D71" /db_xref="PDB:3IAO" /db_xref="PDB:3Q1M" /db_xref="PDB:3Q2Y" /db_xref="PDB:3Q3D" /db_xref="PDB:3Q5P" /db_xref="PDB:3Q5R" /db_xref="PDB:3Q5S" /db_xref="SubtiList:BG10304" /db_xref="UniProtKB/Swiss-Prot:P39075" /translation="MKESYYSIGEVSKLANVSIKALRYYDKIDLFKPAYVDPDTSYRY YTDSQLIHLDLIKSLKYIGTPLEEMKKAQDLEMEELFAFYTEQERQIREKLDFLSALE QTISLVKKRMKRQMEYPALGEVFVLDEEEIRIIQTEAEGIGPENVLNASYSKLKKFIE SADGFTNNSYGATFSFQPYTSIDEMTYRHIFTPVLTNKQISSITPDMEITTIPKGRYA CIAYNFSPEHYFLNLQKLIKYIADRQLTVVSDVYELIIPIHYSPKKQEEYRVEMKIRI AE*" /label="bmrR CDS" gene 2082951..2083787 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /label="bmrR gene" downshifts 2083785 /Source="Nicolas_upshifts" /id="D1257" /incds=0 /nref=5 /ntot=156 /MaxReadThrough="4.1979" /MaxDrop="4.72542" /score="5.00815505" /energy="-15.7" /TU="NA" /idTUdmin="U1876" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2083849) /Source="Nicolas_upshifts" /id="D1258" /incds=0 /nref=15 /ntot=247 /MaxReadThrough="3.01431" /MaxDrop="6.04069" /score="8.5296919" /energy="-16.8" /TU="U1879" /idTUdmin="U1878" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(2083849..2085123) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /EC_number="2.3.1.168" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase)" /protein_id="NP_390283.1" /db_xref="EnsemblGenomes-Gn:BSU24030" /db_xref="EnsemblGenomes-Tr:CAB14334" /db_xref="GOA:P37942" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10305" /db_xref="UniProtKB/Swiss-Prot:P37942" /translation="MAIEQMTMPQLGESVTEGTISKWLVAPGDKVNKYDPIAEVMTDK VNAEVPSSFTGTITELVGEEGQTLQVGEMICKIETEGANPAEQKQEQPAASEAAENPV AKSAGAADQPNKKRYSPAVLRLAGEHGIDLDQVTGTGAGGRITRKDIQRLIETGGVQE QNPEELKTAAPAPKSASKPEPKEETSYPASAAGDKEIPVTGVRKAIASNMKRSKTEIP HAWTMMEVDVTNMVAYRNSIKDSFKKTEGFNLTFFAFFVKAVAQALKEFPQMNSMWAG DKIIQKKDINISIAVATEDSLFVPVIKNADEKTIKGIAKDITGLAKKVRDGKLTADDM QGGTFTVNNTGSFGSVQSMGIINYPQAAILQVESIVKRPVVMDNGMIAVRDMVNLCLS LDHRVLDGLVCGRFLGRVKQILESIDEKTSVY*" /label="bkdB CDS" gene complement(2083849..2085123) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /label="bkdB gene" CDS complement(2085146..2086129) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /EC_number="1.2.4.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390284.1" /db_xref="EnsemblGenomes-Gn:BSU24040" /db_xref="EnsemblGenomes-Tr:CAB14335" /db_xref="GOA:P37941" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10306" /db_xref="UniProtKB/Swiss-Prot:P37941" /translation="MSVMSYIDAINLAMKEEMERDSRVFVLGEDVGRKGGVFKATAGL YEQFGEERVMDTPLAESAIAGVGIGAAMYGMRPIAEMQFADFIMPAVNQIISEAAKIR YRSNNDWSCPIVVRAPYGGGVHGALYHSQSVEAIFANQPGLKIVMPSTPYDAKGLLKA AVRDEDPVLFFEHKRAYRLIKGEVPADDYVLPIGKADVKREGDDITVITYGLCVHFAL QAAERLEKDGISAHVVDLRTVYPLDKEAIIEAASKTGKVLLVTEDTKEGSIMSEVAAI ISEHCLFDLDAPIKRLAGPDIPAMPYAPTMEKYFMVNPDKVEAAMRELAEF*" /label="bkdAB CDS" gene complement(2085146..2086129) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /label="bkdAB gene" CDS complement(2086143..2087135) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /EC_number="1.2.4.4" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390285.1" /db_xref="EnsemblGenomes-Gn:BSU24050" /db_xref="EnsemblGenomes-Tr:CAB14336" /db_xref="GOA:P37940" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR034616" /db_xref="SubtiList:BG10307" /db_xref="UniProtKB/Swiss-Prot:P37940" /translation="MSTNRHQALGLTDQEAVDMYRTMLLARKIDERMWLLNRSGKIPF VISCQGQEAAQVGAAFALDREMDYVLPYYRDMGVVLAFGMTAKDLMMSGFAKAADPNS GGRQMPGHFGQKKNRIVTGSSPVTTQVPHAVGIALAGRMEKKDIAAFVTFGEGSSNQG DFHEGANFAAVHKLPVIFMCENNKYAISVPYDKQVACENISDRAIGYGMPGVTVNGND PLEVYQAVKEARERARRGEGPTLIETISYRLTPHSSDDDDSSYRGREEVEEAKKSDPL LTYQAYLKETGLLSDEIEQTMLDEIMAIVNEATDEAENAPYAAPESALDYVYAK*" /label="bkdAA CDS" gene complement(2086143..2087135) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /label="bkdAA gene" CDS complement(2087157..2088581) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /EC_number="1.8.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase)" /protein_id="NP_390286.2" /db_xref="EnsemblGenomes-Gn:BSU24060" /db_xref="EnsemblGenomes-Tr:CAB14337" /db_xref="GOA:P54533" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11725" /db_xref="UniProtKB/Swiss-Prot:P54533" /translation="MATEYDVVILGGGTGGYVAAIRAAQLGLKTAVVEKEKLGGTCLH KGCIPSKALLRSAEVYRTAREADQFGVETAGVSLNFEKVQQRKQAVVDKLAAGVNHLM KKGKIDVYTGYGRILGPSIFSPLPGTISVERGNGEENDMLIPKQVIIATGSRPRMLPG LEVDGKSVLTSDEALQMEELPQSIIIVGGGVIGIEWASMLHDFGVKVTVIEYADRILP TEDLEISKEMESLLKKKGIQFITGAKVLPDTMTKTSDDISIQAEKDGETVTYSAEKML VSIGRQANIEGIGLENTDIVTENGMISVNESCQTKESHIYAIGDVIGGLQLAHVASHE GIIAVEHFAGLNPHPLDPTLVPKCIYSSPEAASVGLTEDEAKANGHNVKIGKFPFMAI GKALVYGESDGFVKIVADRDTDDILGVHMIGPHVTDMISEAGLAKVLDATPWEVGQTI HPHPTLSEAIGEAALAADGKAIHF*" /label="lpdV CDS" gene complement(2087157..2088581) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /label="lpdV gene" CDS complement(2088602..2089693) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /EC_number="2.7.2.-" /EC_number="2.7.2.7" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain fatty-acid kinase" /protein_id="NP_390287.2" /db_xref="EnsemblGenomes-Gn:BSU24070" /db_xref="EnsemblGenomes-Tr:CAB14338" /db_xref="GOA:P54532" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR011245" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG11724" /db_xref="UniProtKB/Swiss-Prot:P54532" /translation="MKVLHDEKRILTINPGSTSTKIGVFHNERSIFEKTLRHNIEELQ RFDRIIDQYEFRKNHILETLHEQGINISKFDAVCARGGLLRPIEGGTYVVNDEMIEDL KSGYAGQHASNLGGIIAREIADGLNIPSYIVDPVVVDEMSVLAKVSGMPEIERKSIFH ALNQKAVARKAAASLGKRYENMKMIITHMGGGITIGVHDRGRVVDVNNGLHGEGPFSP ERAGTVPAGDLVDLCFSGEYTKEEIMKKLVGTGGLLGYLGTNDAVKVEQMIQGGDEKA RFIYDAMAYQVAKEIGAASAALKGEVEAIVLTGGLAYGKSFVSAIRSYIDWISDVLVY PGENELQSLAQGALRVLQGEEQSKQYRIE*" /label="buk CDS" gene complement(2088602..2089693) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /label="buk gene" CDS complement(2089712..2090806) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /EC_number="1.4.1.8" /EC_number="1.4.1.-" /EC_number="1.4.1.9" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid dehydrogenase" /protein_id="NP_390288.1" /db_xref="EnsemblGenomes-Gn:BSU24080" /db_xref="EnsemblGenomes-Tr:CAB14339" /db_xref="GOA:P54531" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR016211" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11723" /db_xref="UniProtKB/Swiss-Prot:P54531" /translation="MELFKYMEKYDYEQLVFCQDEQSGLKAIIAIHDTTLGPALGGTR MWTYENEEAAIEDALRLARGMTYKNAAAGLNLGGGKTVIIGDPRKDKNEEMFRAFGRY IQGLNGRYITAEDVGTTVEDMDIIHDETDYVTGISPAFGSSGNPSPVTAYGVYRGMKA AAKAAFGTDSLEGKTIAVQGVGNVAYNLCRHLHEEGANLIVTDINKQSVQRAVEDFGA RAVDPDDIYSQDCDIYAPCALGATINDDTIKQLKAKVIAGAANNQLKETRHGDQIHEM GIVYAPDYVINAGGVINVADELYGYNAERALKKVEGIYGNIERVLEISQRDGIPAYLA ADRLAEERIERMRRSRSQFLQNGHSVLSRR*" /label="bcd CDS" gene complement(2089712..2090806) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /label="bcd gene" CDS complement(2090818..2091717) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /EC_number="2.3.1.19" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphate BCFA and butyryl coenzyme A transferase" /protein_id="NP_390289.2" /db_xref="EnsemblGenomes-Gn:BSU24090" /db_xref="EnsemblGenomes-Tr:CAB14340" /db_xref="GOA:P54530" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR012147" /db_xref="InterPro:IPR014079" /db_xref="SubtiList:BG11722" /db_xref="UniProtKB/Swiss-Prot:P54530" /translation="MKLKDLIGKASIHKNKTIAVAHAEDEEVIRAVKLAAEHLSARFL LTGDSKKLNELTSSMQGHQVEIVHANTPEESAKLAVRAVHHKTADVLMKGNVPTSVLL KAVLNRQEGLRSASVLSHVAVFDIPDFDRLMFVTDSAMNIAPSLEELRQILQNAVHVA HAVGNNMPKAAALAAVETVNPKMEATVNAAALAQMYKRGQIKGCIVDGPLALDNAVSQ IAAAQKKISGDVAGNADILLVPTIEAGNILYKSLIYFAKASVAAVITGAKAPIALTSR ADSAENKLYSIALAICASEEYTH*" /label="ptb CDS" gene complement(2090818..2091717) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /label="ptb gene" misc_feature complement(2091753..2091772) /Source="Nicolas_upshift_promotors" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2091758) /Source="Nicolas_upshifts" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2091760..2091841) /Source="Nicolas_S_feature" /locus_tag="new_2504707_2504788_c" /HighExp="Cold, LBGtran, G180, Lbexp, G135, G150, LBGexp, Diami, Oxctl, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S910" CDS complement(2091842..2093920) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_390290.1" /db_xref="EnsemblGenomes-Gn:BSU24100" /db_xref="EnsemblGenomes-Tr:CAB14341" /db_xref="GOA:P54529" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11721" /db_xref="UniProtKB/Swiss-Prot:P54529" /translation="MQKVLIVGAGKRGTALLHILIKTAIIDIIAVVDKDPEAPGLKEA EQYGIAVSSDWKPYIQQKPDIVIHTTGDQAVFDELLQRKHEDTIVMPGKMAYIVFQLM EEKQHLIQMLKEQTYKYDRIFNSTHDGMIFIDINEEIILFNHMAEKMVGKKREEVIGR PIKEVIPSTKMPRILKTRVPEYNQKQLLGDHLQIVTTRLPIIDEGGRLLGALCVFKDI TDAVELAEEVTNLKQVRTMLEAIIQSSDEAISVVDENGIGLLINKAYTKMTGLSEKEV IGKPANTDISEGESMHLKVLETRRPVRGVRMKVGPNEKEVIVNVAPVIVDGILKGSVG VIHDVSEIKMLTAELNRARQIIRTLEAKYTFDDIIGKSEQMLVALEQAKLGAKTPATI LLRGESGTGKELFAHAIHNESDRKYNKFIRVNCAALSENLLESELFGYEDGAFSGAKR GGKKGLFEEANNGSIFLDEIGELTQNMQAKLLRVLQEKEIVRVGGTKAIPVNVRVIAA TNVNIEKAMADGTFREDLYYRINRYPISIPPLRQRLEDIEALSVRLIQKINRDYGRNV KGLSQQALRALSAYHWPGNVRELENVLGRAMIFLNPHMEWIEKDHLPVFELEQKENDT DQGTGFDFPDIEGEKLSVAVEKFEAHLIQQTLEKHHFNRTKTAKALGVSIRNLYYKMD KYGLANEGMQ*" /label="bkdR CDS" gene complement(2091842..2093920) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /label="bkdR gene" promotor_-10 complement(2093980..2093999) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2093997) /Source="Nicolas_upshifts" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2094007..2094014 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2094016..2094019) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2094028..2094047 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2094035 /Source="Nicolas_upshifts" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="upshifts" CDS 2094073..2094309 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390291.1" /db_xref="EnsemblGenomes-Gn:BSU24110" /db_xref="EnsemblGenomes-Tr:CAB14342" /db_xref="GOA:O32015" /db_xref="InterPro:IPR020138" /db_xref="SubtiList:BG13772" /db_xref="UniProtKB/Swiss-Prot:O32015" /translation="MSRLLALLILVIPGAISALGIKLMRDTLFGHTIKPFSALWLQGL SGFIFFAIGLYVLAGFILYRDRKRNQVSPRFRKR*" /label="yqzF CDS" gene 2094073..2094309 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /label="yqzF gene" downshifts 2094300 /Source="Nicolas_upshifts" /id="D1259" /incds=0 /nref=64 /ntot=230 /MaxReadThrough="2.80342" /MaxDrop="5.10794" /score="42.7247617" /energy="-11.9" /TU="NA" /idTUdmin="U1880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2094351..2095256) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /EC_number="4.1.3.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12706720, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12706720, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylisocitrate lyase" /protein_id="NP_390292.1" /db_xref="EnsemblGenomes-Gn:BSU24120" /db_xref="EnsemblGenomes-Tr:CAB14343" /db_xref="GOA:P54528" /db_xref="InterPro:IPR012695" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018523" /db_xref="SubtiList:BG11720" /db_xref="UniProtKB/Swiss-Prot:P54528" /translation="MSWIVNKQSSQEELAGRFRKLMSAPDILQIPGAHDGMAALLAKE AGFSAIYLSGAAYTASRGLPDLGIITSAEIAERAKDLVRAADLPLLVDIDTGFGGVLN AARTAREMLEARVAAVQMEDQQLPKKCGHLNGKQLVPIKEMAQKIKAIKQAAPSLIVV ARTDARAQEGLDAAIKRSEAYIEAGADAIFPEALQAENEFRQFAERIPVPLLANMTEF GKTPYYRADEFEDMGFHMVIYPVTSLRAAAKACERMFGLMKEHGSQKEGLHDMQTRKE LYDTISYYDYEALDKTIAKTVLPDE*" /label="mmgF CDS" gene complement(2094351..2095256) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /label="mmgF gene" downshifts complement(2094354) /Source="Nicolas_upshifts" /id="D1260" /incds=0 /nref=29 /ntot=69 /MaxReadThrough="2.12559" /MaxDrop="5.62" /score="33.814061" /energy="-11.9" /TU="NA" /idTUdmin="U1884" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2095274..2096692) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /EC_number="4.2.1.79" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylcitrate dehydratase (promiscuous)" /protein_id="NP_390293.2" /db_xref="EnsemblGenomes-Gn:BSU24130" /db_xref="EnsemblGenomes-Tr:CAB14344" /db_xref="GOA:P45859" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR012705" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11323" /db_xref="UniProtKB/Swiss-Prot:P45859" /translation="MPKTDRVIEEITDYVLEKEITSAEAYTTAGHVLLDTLGCGILAL RYPECTKLLGPIVPGTTVPNGSKVPGTSYVLDPVRAAFNIGCMIRWLDYNDTWLAAEW GHPSDNLGGILAAADYVSRVRLSEGKEPLTVRDVLEMMIKAHEIQGVLALENSLNRVG LDHVLFVKVATTAVAAKLLGGGREEIKNALSNAWIDNAALRTYRHSPNTGSRKSWAAG DATSRGVHLALMSLKGEMGYPTALSAPGWGFQDVLFNKKEIKLARPLDAYVMENVLFK VSYPAEFHAQTAAESAVILHPQVKNRIDEIDRVVIRTHESAIRIIDKKGPLHNPADRD HCLQYITAIGLLFGDITAQHYEAETANDPRIDKLRDKMEVTENKTYTEDYLKPDKRSI SNAVQVHFKDGTSTEMVECEFPLGHRFRREEAVPKLLEKFSDNLKTHFPDKQHKHIYE RCTSYETLQTMRVNEFVDMFCM*" /label="mmgE CDS" gene complement(2095274..2096692) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /label="mmgE gene" misc_feature complement(2095569..2095588) /Source="Nicolas_upshift_promotors" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2095586) /Source="Nicolas_upshifts" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2096707..2097825) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /EC_number="2.3.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional citrate synthase/2-methylcitrate synthase" /protein_id="NP_390294.1" /db_xref="EnsemblGenomes-Gn:BSU24140" /db_xref="EnsemblGenomes-Tr:CAB14345" /db_xref="GOA:P45858" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG11322" /db_xref="UniProtKB/Swiss-Prot:P45858" /translation="MEEKQHYSPGLDGVIAAETHISYLDTQSSQILIRGYDLIELSET KSYLELVHLLLEGRLPEESEMETLERKINSASSLPADHLRLLELLPEDTHPMDGLRTG LSALAGYDRQIDDRSPSANKERAYQLLGKMPALTAASYRIINKKEPILPLQTLSYSAN FLYMMTGKLPSSLEEQIFDRSLVLYSEHEMPNSTFAARVIASTHSDLYGALTGAVASL KGNLHGGANEAVMYLLLEAKTTSDFEQLLQTKLKRKEKIMGFGHRVYMKKMDPRALMM KEALQQLCDKAGDHRLYEMCEAGERLMEKEKGLYPNLDYYAAPVYWMLGIPIPLYTPI FFSARTSGLCAHVIEQHANNRLFRPRVSYMGPRYQTKS*" /label="mmgD CDS" gene complement(2096707..2097825) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /label="mmgD gene" CDS complement(2097859..2098998) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="propionyl-CoA dehydrogenase subunit" /protein_id="NP_390295.2" /db_xref="EnsemblGenomes-Gn:BSU24150" /db_xref="EnsemblGenomes-Tr:CAB14346" /db_xref="GOA:P45857" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="PDB:5LNX" /db_xref="SubtiList:BG11321" /db_xref="UniProtKB/Swiss-Prot:P45857" /translation="MHVTQEQVMMRKMVRDFARKEIAPAAEIMEKTDEFPFQLIKKMG KHGLMGIPVPEQYGGAGADVVSYILAIHEISRISAAVGVILSVHTSVGTNPILYFGNE EQKMKYIPNLASGDHLGAFALTEPHSGSDAGSLRTTAIKKNGKYLLNGSKIFITNGGA ADIYITFALTAPDQGRHGISAFIVEKNTPGFTVGKKERKLGLYGSNTTELIFDNAEVP EANLLGKEGDGFHIAMANLNVGRIGIAAQALGIAEAALEHAVDYAKQRVQFGRPIAAN QGISFKLADMATRAEAARHLVYHAADLHNRGLNCGKEASMAKQFASDAAVKAALDAVQ IYGGYGYMKDYPVERLLRDAKVTQIYEGTNEIQRLIISKYLLGGT*" /label="mmgC CDS" gene complement(2097859..2098998) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /label="mmgC gene" CDS complement(2099026..2099889) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /EC_number="1.1.1.157" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 18461320, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 18461320, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxybutyryl-CoA dehydrogenase" /protein_id="NP_390296.2" /db_xref="EnsemblGenomes-Gn:BSU24160" /db_xref="EnsemblGenomes-Tr:CAB14347" /db_xref="GOA:P45856" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR006180" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR022694" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11320" /db_xref="UniProtKB/Swiss-Prot:P45856" /translation="MEIKQIMVAGAGQMGSGIAQTAADAGFYVRMYDVNPEAAEAGLK RLKKQLARDAEKGKRTETEVKSVINRISISQTLEEAEHADIVIEAIAENMAAKTEMFK TLDRICPPHTILASNTSSLPITEIAAVTNRPQRVIGMHFMNPVPVMKLVEVIRGLATS EETALDVMALAEKMGKTAVEVNDFPGFVSNRVLLPMINEAIYCVYEGVAKPEAIDEVM KLGMNHPMGPLALADFIGLDTCLSIMEVLHSGLGDSKYRPCPLLRKYVKAGWLGKKSG RGFYDYEEKTS*" /label="mmgB CDS" gene complement(2099026..2099889) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /label="mmgB gene" CDS complement(2099914..2101095) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /EC_number="2.3.1.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16352833, 18246303, 19016856, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352833, 18246303, 19016856, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="degradative acetoacetyl-CoA thiolase" /protein_id="NP_390297.1" /db_xref="EnsemblGenomes-Gn:BSU24170" /db_xref="EnsemblGenomes-Tr:CAB14348" /db_xref="GOA:P45855" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="PDB:5LP7" /db_xref="SubtiList:BG11319" /db_xref="UniProtKB/Swiss-Prot:P45855" /translation="MRKTVIVSAARTPFGKFGGVLKEVKAAELGGIVMKEALQQAGVS GDDVEGNVMGMVVQAGSGQIPSRQAARLAGMPWSVPSETLNKVCASGLRAVTLCDQMI RAQDADILVAGGMESMSNIPYAVPAGRWGARMGDGELRDLMVYDGLTCAFDEVHMAVH GNTAAKEYAISRREQDEWALRSHARAAKAADEGKFQDEIVPVNWIGRKGKPNVVDKDE AIRRDTSLDQLAKLAPIYASDGSITAGNAPGVNDGAGAFVLMSEEKAAELGKRPLATI LGFSTTGMPAHELAAAPGFAINKLLKKNGLTVQDIDLFEVNEAFASVVLTCEKIVGFD LEKVNVNGGAIALGHPIGASGARILMTLVYELKRRGGGLGVAAICSGAAQGDAVLVQV H*" /label="mmgA CDS" gene complement(2099914..2101095) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /label="mmgA gene" downshifts complement(2100675) /Source="Nicolas_upshifts" /id="D1261" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17207" /MaxDrop="2.33167" /score="-0.949614429" /energy="-7.8" /TU="U1884" /idTUdmin="U1885" /TUdmin=550 /isTUend="FALSE" /label="downshifts" misc_feature complement(2100782..2100788) /Source="Nicolas_upshift_promotors" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2100785) /Source="Nicolas_upshifts" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(2101009..2101109) /Source="Nicolas_upshift_promotors" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2101049) /Source="Nicolas_upshifts" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2101142..2101160) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2101160) /Source="Nicolas_upshifts" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2101176..2101181) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2101222..2101953) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /EC_number="3.1.4.46" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 14563871, 21966272, 22843846, 24373430, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 14563871, 21966272, 22843846, 24373430, 27780866; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycerophosphodiester phosphodiesterase (exolytic cleavage of individual teichoic acid monomer units)" /protein_id="NP_390298.2" /db_xref="EnsemblGenomes-Gn:BSU24180" /db_xref="EnsemblGenomes-Tr:CAB14349" /db_xref="GOA:P54527" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG11719" /db_xref="UniProtKB/Swiss-Prot:P54527" /translation="MTKIFAHRGASGQFPENTMLAFEKGIEAGADGIELDVQLTKDGR IVVIHDERLNRTTSLKGFVKDTAYDEVKTANAAAGHDQAYSDIKVPLLEDVLSWAVKK DFLINIELKNSVIRYEGMEEKVLEAVKRFNVEDRVILSTFNHDSLALCARLAPHIERA VLTSDVLYQADRYIASIPASGYHPKINSPGVTDEVLKKMRNGLIKVRPYTVNRPEDMK RLIEAGADGMFTDFPEKASALLKNE*" /label="glpQ CDS" gene complement(2101222..2101953) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /label="glpQ gene" downshifts complement(2101229) /Source="Nicolas_upshifts" /id="D1262" /incds=0 /nref=31 /ntot=180 /MaxReadThrough="0.31166" /MaxDrop="4.10202" /score="-0.949614429" /energy="-7.8" /TU="NA" /idTUdmin="U1885" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2101976..2101995) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2101987) /Source="Nicolas_upshifts" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2102010..2102013) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2102032..2102652) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /EC_number="3.5.1.28" /experiment="publication(s) with functional evidences, PMID:22843846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22843846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_390299.2" /db_xref="EnsemblGenomes-Gn:BSU24190" /db_xref="EnsemblGenomes-Tr:CAB14350" /db_xref="GOA:P54525" /db_xref="InterPro:IPR002508" /db_xref="SubtiList:BG11717" /db_xref="UniProtKB/Swiss-Prot:P54525" /translation="MRMLWRSLALCGLALTLAPCAQAAEPIEGKTVYIDAGHGGEDSG AVGNGLFEKDINLAVSEHVTDKLKEEGANPVASRSDDHFLTLEERVAKASANQADLFV SIHVNSGVASASGTETYFQSDYEGENSRRLASDIQSQLVSSLQTRDRGVKESDFYVIT YSQMPSVLAELGFITNSSDADKLGSEEYQQKAADAIVNGIDSYYDQ*" /label="yqiI CDS" gene complement(2102032..2102652) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /label="yqiI gene" CDS complement(2102667..2102960) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22843846; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390300.2" /db_xref="EnsemblGenomes-Gn:BSU24200" /db_xref="EnsemblGenomes-Tr:CAB14351" /db_xref="GOA:P40770" /db_xref="SubtiList:BG11030" /db_xref="UniProtKB/Swiss-Prot:P40770" /translation="MKQTVLLLFTALFLSGCSVASADDSVPRFTEEGKYIGSADPHTI AVSLNGEETMIQVPKDKRDECESLPDQTHVLVKYTKKDNGTLQLEDIQLRKNS*" /label="yqiH CDS" gene complement(2102667..2102960) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /label="yqiH gene" promotor_-10 complement(2102980..2102999) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2102986) /Source="Nicolas_upshifts" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2103014..2103021) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2103216..2103223 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2103237..2103256 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2103254..2103459 /Source="Nicolas_S_feature" /locus_tag="new_2516201_2516406" /HighExp="Diami, dia15, dia5, H2O2, Paraq, LBGexp, G180, LBGstat, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99653599999999998" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S911" upshifts 2103254 /Source="Nicolas_upshifts" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="upshifts" CDS 2103268..2103420 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513977.1" /translation="MKEVKAMKKFVLLLAAAVITCSIGHQISGGYKGPEKERPKHHSA LKIFSR*" /label="hypothetical protein CDS" gene 2103268..2103420 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /label="gene" promotor_-35 2103428..2103435 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2103450..2103469 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2103461 /Source="Nicolas_upshifts" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="upshifts" CDS 2103493..2104611 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-dependent flavin oxidoreductase" /protein_id="NP_390301.1" /db_xref="EnsemblGenomes-Gn:BSU24210" /db_xref="EnsemblGenomes-Tr:CAB14352" /db_xref="GOA:P54524" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11716" /db_xref="UniProtKB/Swiss-Prot:P54524" /translation="MNPKYKPLFEPFTFKSGVTINNRIAVAPMTHYASNEDGTISEAE LDYIIPRSKEMGMVITACANVTPDGKAFPGQPAIHDDSNIPGLKKLAQAIQAQGAKAV VQIHHGGIECPSELVPQQDVVGPSDVFDNGKQIARALTEEEVENIVKAFGEATRRAIE AGFDGVEIHGANGYLIQQFYSPKTNQRTDRWGGSDEKRLAFPLAIVDEVKKAASEHAK GAFLVGYRLSPEEPETPGLTMTETYTLVDALGDKELDYLHISLMDVNSKARRGADPTR TRMDLLNERVGNKVPLIAVGSIHSADDALAVIENGIPLVAMGREILVDPNWTVKVKEG REKQIETVIKGTDKEKYHLPEPLWQAIVNTQGWVPYKD*" /label="yqiG CDS" gene 2103493..2104611 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /label="yqiG gene" downshifts 2104596 /Source="Nicolas_upshifts" /id="D1263" /incds=0 /nref=23 /ntot=181 /MaxReadThrough="1.88324" /MaxDrop="6.67511" /score="30.8551972" /energy="-16.1" /TU="NA" /idTUdmin="U1887" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(2104638..2104808) /Source="Nicolas_S_feature" /locus_tag="new_2517585_2517755_c" /HighExp="T0.30H, S6, S8, T1.30H, T1.0H, T-0.40H, S7, Salt, T0.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="1, 0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S912" downshifts complement(2104681) /Source="Nicolas_upshifts" /id="D1264" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="3.46085" /MaxDrop="2.69939" /score="-5.47428449" /energy="-16.1" /TU="U1889" /idTUdmin="U1890" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2104792..2104807) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2104808) /Source="Nicolas_upshifts" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2104810..2104938) /Source="Nicolas_S_feature" /locus_tag="new_2517757_2517885_c" /HighExp="S6, S8, S7, S5, BT, M9-stat, B36, G180, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S913" promotor_-35 complement(2104819..2104828) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2104937..2104956) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2104960) /Source="Nicolas_upshifts" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2104970..2104978) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2105070) /Source="Nicolas_upshifts" /id="D1265" /incds=0 /nref=199 /ntot=267 /MaxReadThrough="2.54843" /MaxDrop="4.82417" /score="-1.10791055" /energy="-15.5" /TU="NA" /idTUdmin="U1891" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2105076..2105879) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator, phosphorylated in response to complex YlbF/YmcA/YaaT" /protein_id="NP_390302.1" /db_xref="EnsemblGenomes-Gn:BSU24220" /db_xref="EnsemblGenomes-Tr:CAB14353" /db_xref="GOA:P06534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR012052" /db_xref="InterPro:IPR014879" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1LQ1" /db_xref="SubtiList:BG10765" /db_xref="UniProtKB/Swiss-Prot:P06534" /translation="MEKIKVCVADDNRELVSLLSEYIEGQEDMEVIGVAYNGQECLSL FKEKDPDVLVLDIIMPHLDGLAVLERLRESDLKKQPNVIMLTAFGQEDVTKKAVDLGA SYFILKPFDMENLVGHIRQVSGNASSVTHRAPSSQSSIIRSSQPEPKKKNLDASITSI IHEIGVPAHIKGYLYLREAISMVYNDIELLGSITKVLYPDIAKKFNTTASRVERAIRH AIEVAWSRGNIDSISSLFGYTVSMTKAKPTNSEFIAMVADKLRLEHKAS*" /label="spo0A CDS" gene complement(2105076..2105879) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /label="spo0A gene" promotor_-10 complement(2105922..2105940) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2105928) /Source="Nicolas_upshifts" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2105930..2106082) /Source="Nicolas_S_feature" /locus_tag="new_2518877_2519029_c" /HighExp="T1.30H, T3.0H, T2.30H, T2.0H, HiTm, Lbtran, T1.0H, T-0.40H, T0.30H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S914" promotor_-35 complement(2105951..2105959) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2106078..2106097) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2106090) /Source="Nicolas_upshifts" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2106109..2106116) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2106155..2107435) /gene="spoIVB" /locus_tag="BSU_24230" /old_locus_tag="BSU24230" /EC_number="3.4.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12218026, 15292188, 16164552, 16238631, 16818230, 17493131, 17557826" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12218026, 15292188, 16164552, 16238631, 16818230, 17493131, 17557826; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="regulatory membrane-associated serine protease" /protein_id="NP_390303.2" /db_xref="EnsemblGenomes-Gn:BSU24230" /db_xref="EnsemblGenomes-Tr:CAB14354" /db_xref="GOA:P17896" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR008763" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR014219" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG10311" /db_xref="UniProtKB/Swiss-Prot:P17896" /translation="MPDNIRKAVGLILLVSLLSVGLCKPLKEYLLIPTQMRVFETQTQ AIETSLSVNAQTSESSEAFTVKKDPHEIKVTGKKSGESELVYDLAGFPIKKTKVHVLP DLKVIPGGQSIGVKLHSVGVLVVGFHQINTSEGKKSPGETAGIEAGDIIIEMNGQKIE KMNDVAPFIQKAGKTGESLDLLIKRDKQKIKTKLIPEKDEGEGKYRIGLYIRDSAAGI GTMTFYEPKTKKYGALGHVISDMDTKKPIVVENGEIVKSTVTSIEKGTGGNPGEKLAR FSSERKTIGDINRNSPFGIFGTLHQPIQNNISDQALPVAFSTEVKKGPAEILTVIDDD KVEKFDIEIVSTTPQKFPATKGMVLKITDPRLLKETGGIVQGMSGSPIIQNGKVIGAV THVFVNDPTSGYGVHIEWMLSEAGIDIYGKEKAS*" /label="spoIVB CDS" gene complement(2106155..2107435) /gene="spoIVB" /locus_tag="BSU_24230" /old_locus_tag="BSU24230" /label="spoIVB gene" downshifts complement(2106170) /Source="Nicolas_upshifts" /id="D1266" /incds=0 /nref=34 /ntot=51 /MaxReadThrough="1.04939" /MaxDrop="7.80695" /score="49.1812184" /energy="-12.5" /TU="NA" /idTUdmin="U1893" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2107496..2107507) /Source="Nicolas_upshift_promotors" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2107510) /Source="Nicolas_upshifts" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2107522..2107528) /Source="Nicolas_upshift_promotors" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2107610..2109340) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /function="16.8: Protect" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor for double strand breaks DNA repair and genetic recombination" /protein_id="NP_390304.2" /db_xref="EnsemblGenomes-Gn:BSU24240" /db_xref="EnsemblGenomes-Tr:CAB14355" /db_xref="GOA:P17894" /db_xref="InterPro:IPR004604" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10310" /db_xref="UniProtKB/Swiss-Prot:P17894" /translation="MLAELSIKNFAIIEELTVSFERGLTVLTGETGAGKSIIIDAISL LVGGRGSSEFVRYGEAKAELEGLFLLESGHPVLGVCAEQGIDVSDEMIVMRRDISTSG KSVCRVNGKLVTIASLREIGRLLLDIHGQHDNQLLMEDENHLQLLDKFAGAEVESALK TYQEGYQRYVKLLKKLKQLSESEQEMAHRLDLIQFQLEEIESAKLELNEDEQLQEERQ QISNFEKIYESLQNAYNALRSEQGGLDWVGMASAQLEDISDINEPLKKMSESVSNSYY LLEDATFQMRNMLDELEFDPERLNYIETRLNEIKQLKRKYGATVEDILEYASKIEEEI DQIENRDSHLQSLKKELDSVGKDVAVEAANVSQIRKTWAKKLADEIHRELKSLYMEKS TFDTEFKVRTASRNEEAPLVNGQPVQLTEQGIDLVKFLISTNTGEPLKSLSKVASGGE LSRVMLAIKSIFSSQQDVTSIIFDEVDTGVSGRVAQAIAEKIHKVSIGSQVLCITHLP QVAAMADTHLYIAKELKDGRTTTRVKPLSKQEKVAEIGRMIAGVEVTDLTKRHAKELL KQADQVKTTG*" /label="recN CDS" gene complement(2107610..2109340) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /label="recN gene" downshifts complement(2107625) /Source="Nicolas_upshifts" /id="D1267" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="1.73202" /MaxDrop="6.33427" /score="20.028822" /energy="-12.4" /TU="NA" /idTUdmin="U1895" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2109377..2109826) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AhrC(ArgR)-arginine)" /protein_id="NP_390305.1" /db_xref="EnsemblGenomes-Gn:BSU24250" /db_xref="EnsemblGenomes-Tr:CAB14356" /db_xref="GOA:P17893" /db_xref="InterPro:IPR001669" /db_xref="InterPro:IPR020899" /db_xref="InterPro:IPR020900" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR036251" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1F9N" /db_xref="PDB:2P5K" /db_xref="PDB:2P5L" /db_xref="PDB:2P5M" /db_xref="SubtiList:BG10309" /db_xref="UniProtKB/Swiss-Prot:P17893" /translation="MNKGQRHIKIREIITSNEIETQDELVDMLKQDGYKVTQATVSRD IKELHLVKVPTNNGSYKYSLPADQRFNPLSKLKRALMDAFVKIDSASHMIVLKTMPGN AQAIGALMDNLDWDEMMGTICGDDTILIICRTPEDTEGVKNRLLELL*" /label="argR CDS" gene complement(2109377..2109826) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /label="argR gene" S_feature complement(2109827..2109912) /Source="Nicolas_S_feature" /locus_tag="new_2522774_2522859_c" /HighExp="H2O2, G180, G135, G150, Oxctl, Heat, Paraq, C30, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S915" CDS complement(2109924..2110769) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /EC_number="2.1.1.-" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2'-O-ribose RNA methyltransferase" /protein_id="NP_390306.2" /db_xref="EnsemblGenomes-Gn:BSU24260" /db_xref="EnsemblGenomes-Tr:CAB14357" /db_xref="GOA:P19672" /db_xref="InterPro:IPR002877" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR004538" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10308" /db_xref="UniProtKB/Swiss-Prot:P19672" /translation="MTSKKERLDVLLVERGLAETREKAKRAIMAGIVYSNENRLDKPG EKIDRDLPLTVKGNPLRYVSRGGLKLEKALKEFPVSVKDKIMIDIGSSTGGFTDCALQ NGAKQSYAVDVGYNQLAWKLRQDERVVVMERTNFRYATPADFTKGMPEFATIDVSFIS LRLILPVLRTLLVPGSDCMALVKPQFEAGRESVGKKGIVRDPKVHADVLKRMISFSAA EGYICKGLSFSPITGGDGNIEFLLHLHWPGEGQEGQELPEEEIMRVVEEAHKTLKEKK ADVPE*" /label="yqxC CDS" gene complement(2109924..2110769) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /label="yqxC gene" downshifts complement(2109957) /Source="Nicolas_upshifts" /id="D1268" /incds=0 /nref=1 /ntot=65 /MaxReadThrough="5.65358" /MaxDrop="2.6955" /score="4.97422627" /energy="-9.4" /TU="U1895,U1896,U1898" /idTUdmin="U1895" /TUdmin="-2332" /isTUend="FALSE" /label="downshifts" CDS complement(2110766..2112667) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /EC_number="2.2.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12882400, 15292217, 17458547, 23840410, 25212876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-deoxyxylulose-5-phosphate synthase" /protein_id="NP_390307.1" /db_xref="EnsemblGenomes-Gn:BSU24270" /db_xref="EnsemblGenomes-Tr:CAB14358" /db_xref="GOA:P54523" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005477" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11715" /db_xref="UniProtKB/Swiss-Prot:P54523" /translation="MDLLSIQDPSFLKNMSIDELEKLSDEIRQFLITSLSASGGHIGP NLGVVELTVALHKEFNSPKDKFLWDVGHQSYVHKLLTGRGKEFATLRQYKGLCGFPKR SESEHDVWETGHSSTSLSGAMGMAAARDIKGTDEYIIPIIGDGALTGGMALEALNHIG DEKKDMIVILNDNEMSIAPNVGAIHSMLGRLRTAGKYQWVKDELEYLFKKIPAVGGKL AATAERVKDSLKYMLVSGMFFEELGFTYLGPVDGHSYHELIENLQYAKKTKGPVLLHV ITKKGKGYKPAETDTIGTWHGTGPYKINTGDFVKPKAAAPSWSGLVSGTVQRMAREDG RIVAITPAMPVGSKLEGFAKEFPDRMFDVGIAEQHAATMAAAMAMQGMKPFLAIYSTF LQRAYDQVVHDICRQNANVFIGIDRAGLVGADGETHQGVFDIAFMRHIPNMVLMMPKD ENEGQHMVHTALSYDEGPIAMRFPRGNGLGVKMDEQLKTIPIGTWEVLRPGNDAVILT FGTTIEMAIEAAEELQKEGLSVRVVNARFIKPIDEKMMKSILKEGLPILTIEEAVLEG GFGSSILEFAHDQGEYHTPIDRMGIPDRFIEHGSVTALLEEIGLTKQQVANRIRLLMP PKTHKGIGS*" /label="dxs CDS" gene complement(2110766..2112667) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /label="dxs gene" promotor_-35 2111875..2111881 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2111896..2111907 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2111904 /Source="Nicolas_upshifts" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2112668..2112796) /Source="Nicolas_S_feature" /locus_tag="new_2525615_2525743_c" /HighExp="Salt, Heat, dia15, H2O2, HiOs, Cold, T-5.40H, T3.30H, SMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S916" promotor_-10 complement(2112791..2112810) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2112796) /Source="Nicolas_upshifts" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2112825..2112831) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2112842..2113732) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /EC_number="2.5.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755734, 12682299, 17147392, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate synthase" /protein_id="NP_390308.2" /db_xref="EnsemblGenomes-Gn:BSU24280" /db_xref="EnsemblGenomes-Tr:CAB14359" /db_xref="GOA:P54383" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG11714" /db_xref="UniProtKB/Swiss-Prot:P54383" /translation="MTNKLTSFLADRKKTIENQLSVYTEKLDMPDSLKKSMLYSLQAG GKRLRPLIVLAVLNAYGKSEKDGIPVGCAVEMIHTYSLIHDDLPCMDDDDLRRGKPTN HKVFGEATAVLAGDGLLTESFKLITSHVSDEVSAEKRLRLVNELISAAGTEGMVGGQV ADMEAENRQVTLEELESIHERKTAKLLGFCVIAGAILADAPEEDIETLRTFSSHIGIG FQIRDDILDLEGSEEKIGKRVGSDTTNDKSTYPSLLSLEGAKHKLDVHIKEAKRLIGG LSLQKDLLYELCDLIAARDH*" /label="ispA CDS" gene complement(2112842..2113732) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /label="ispA gene" CDS complement(2113722..2113976) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /EC_number="3.1.11.6" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11381137, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (small subunit)" /protein_id="NP_390309.2" /db_xref="EnsemblGenomes-Gn:BSU24290" /db_xref="EnsemblGenomes-Tr:CAB14360" /db_xref="GOA:P54522" /db_xref="InterPro:IPR003761" /db_xref="InterPro:IPR037004" /db_xref="SubtiList:BG11713" /db_xref="UniProtKB/Swiss-Prot:P54522" /translation="MTDVKKNENMTFEEAMKGLESIVSKLEEGDVPLEQAINYFQEGM ALSKMCHEKLQKVEKQMDFILKEDGELAPFSVQEEDEGDK*" /label="xseB CDS" gene complement(2113722..2113976) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /label="xseB gene" CDS complement(2113973..2115319) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /EC_number="3.1.11.6" /function="16.9: Replicate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17182742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (large subunit)" /protein_id="NP_390310.2" /db_xref="EnsemblGenomes-Gn:BSU24300" /db_xref="EnsemblGenomes-Tr:CAB14361" /db_xref="GOA:P54521" /db_xref="InterPro:IPR003753" /db_xref="InterPro:IPR020579" /db_xref="InterPro:IPR025824" /db_xref="SubtiList:BG11712" /db_xref="UniProtKB/Swiss-Prot:P54521" /translation="MGEAAYVTVSALTKYIKRKFDVDPHLENIWIKGELSNVKIHTRG HIYFTLKDENARMQSVMFARQSERLPFKPENGMKVLVRGGISVYEPSGNYQLYAKEMQ PDGVGALYLAYEELKKKLAGEGLFDDRYKKQIPAFPATIGVVTSPTGAAVRDVITTLK RRYPLVKVIVLPALVQGENASRSIVTRIEEANEKEICDVLIVGRGGGSIEELWAFNEE IVARAIFASNIPIISAVGHETDFTISDFVADIRAATPTGAAEIAVPHTTDLIERTKTA EVRMTRAMQQHLGQKKERIQTLQSSYAFRFPKRLYAQKEQQFDLAYQQFQAQLTALLD RKSRQLERETYRLEALHPHEQLKQARTRYQEQTNQLRKNMNIQMKQLHSQFQTVLGKL NALSPLQVMERGYSLAYKEDKLIKSVSQIEEQDRLEIKLKDGVLTCEVLEKRGEEK*" /label="xseA CDS" gene complement(2113973..2115319) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /label="xseA gene" S_feature complement(2115320..2115456) /Source="Nicolas_S_feature" /locus_tag="new_2528267_2528403_c" /HighExp="H2O2, G180, G135, Cold, G150, Paraq, Oxctl, LBGstat, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S917" CDS complement(2115457..2116308) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /EC_number="1.5.1.5" /EC_number="3.5.4.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7061514, 9454603, 12682299, 19171795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylenetetrahydrofolate dehydrogenase; methenyltetrahydrofolate cyclohydrolase" /protein_id="NP_390311.1" /db_xref="EnsemblGenomes-Gn:BSU24310" /db_xref="EnsemblGenomes-Tr:CAB14362" /db_xref="GOA:P54382" /db_xref="InterPro:IPR000672" /db_xref="InterPro:IPR020630" /db_xref="InterPro:IPR020631" /db_xref="InterPro:IPR020867" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11711" /db_xref="UniProtKB/Swiss-Prot:P54382" /translation="MTATIIDGKETAREKREQLAKEVEELKKQGVTPGLAVILIGDDP ASHSYVRGKKKAAETMGMNFKLDQFDSSLTEAELLSIIDQYNQDPEFHGILVQLPLPD HISEKAVIERISPDKDVDGFHPLNVGKMLLGEDTFLPCTPHGIVELLKKTNIDLSGKE VVVVGRSNIVGKPVGQLLLNENATVTYCHSRTENITEHTKKADILVVAVGRANFISAD QIKEGAVVIDVGVNRLENGKLCGDVEFEGAKEKASFITPVPGGVGPMTITMLAHNTVK SAKRTLS*" /label="folD CDS" gene complement(2115457..2116308) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /label="folD gene" CDS complement(2116320..2116715) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16707701, 16946247, 27964882; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription termination factor NusB" /protein_id="NP_390312.2" /db_xref="EnsemblGenomes-Gn:BSU24320" /db_xref="EnsemblGenomes-Tr:CAB14363" /db_xref="GOA:P54520" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR011605" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG11710" /db_xref="UniProtKB/Swiss-Prot:P54520" /translation="MKRRTAREKALQALFQIDVSDIAVNEAIEHALDEEKTDPFFEQL VHGVLEHQDQLDEMISKHLVNWKLDRIANVDRAILRLAAYEMAYAEDIPVNVSMNEAI ELAKRFGDDKATKFVNGVLSNIKSDIEQS*" /label="nusB CDS" gene complement(2116320..2116715) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /label="nusB gene" misc_feature complement(2116758..2116777) /Source="Nicolas_upshift_promotors" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2116777) /Source="Nicolas_upshifts" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2116779..2116941) /Source="Nicolas_S_feature" /locus_tag="new_2529726_2529888_c" /HighExp="G180, G150, Oxctl, Etha, G135, GM 120, dia0, HPh, MG 150, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S918" CDS complement(2116979..2117386) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 17114254, 22720735, 28579978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 17114254, 22720735, 28579978; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="alkaline shock protein" /protein_id="NP_390313.2" /db_xref="EnsemblGenomes-Gn:BSU24330" /db_xref="EnsemblGenomes-Tr:CAB14364" /db_xref="InterPro:IPR005531" /db_xref="SubtiList:BG11709" /db_xref="UniProtKB/Swiss-Prot:P54519" /translation="MKDNSLLKMDHEDTHLGKVEIAPEVIEVIAGIAASEVDGVAEMR GNFATGVVERFGKVNHGKGVKVDLADDGITIDVYCVVTFGVSIPKVAASVQENIRQTL LNMTSLSINEINIHIVGIQFDTKAQEVQIDEEM*" /label="yqhY CDS" gene complement(2116979..2117386) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /label="yqhY gene" downshifts complement(2116986) /Source="Nicolas_upshifts" /id="D1269" /incds=0 /nref=6 /ntot=76 /MaxReadThrough="6.4099" /MaxDrop="4.1473" /score="9.44795832" /energy="-9.5" /TU="U1897,U1898" /idTUdmin="U1899" /TUdmin=2409 /isTUend="FALSE" /label="downshifts" CDS complement(2117407..2118759) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /EC_number="6.3.4.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxylase subunit)" /protein_id="NP_390314.2" /db_xref="EnsemblGenomes-Gn:BSU24340" /db_xref="EnsemblGenomes-Tr:CAB14365" /db_xref="GOA:P49787" /db_xref="InterPro:IPR004549" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11384" /db_xref="UniProtKB/Swiss-Prot:P49787" /translation="MIKKLLIANRGEIAVRIIRACRELGIETVAVYSEADKDALHVQM ADEAFCIGPKASKDSYLNVTNIVSVAKLTGTDAIHPGYGFLAENADFAELCEEVNVTF VGPSADAISKMGTKDVARETMKQAGVPIVPGSQGIIENVEEAVSLANEIGYPVIIKAT AGGGGKGIRVARTEEELINGIKITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADNY GNTIHLGERDCSIQRRLQKLLEESPSPALDSEIREQMGDAAVKAAKAVGYTGAGTVEF IYDYNEQRYYFMEMNTRIQVEHPVTEMVTGTDLIKEQIKVASGMELSLKQEDVEFEGW AIECRINAENPSKNFMPSPGEIKMYLPPGGLGVRVDSAAYPGYSIPPYYDSMIAKVIT YGKTRDEAIARMKRALSEFVIEGIETTIPFHLKLLEHETFVSGEFNTKFLETYDVMGS *" /label="accC CDS" gene complement(2117407..2118759) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /label="accC gene" promotor_-10 complement(2118288..2118307) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-10" upshifts complement(2118295) /Source="Nicolas_upshifts" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="upshifts" promotor_-35 complement(2118322..2118328) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-35" CDS complement(2118771..2119250) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796, 15518551" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796, 15518551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxyl carrier subunit)" /protein_id="NP_390315.1" /db_xref="EnsemblGenomes-Gn:BSU24350" /db_xref="EnsemblGenomes-Tr:CAB14366" /db_xref="GOA:P49786" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001249" /db_xref="InterPro:IPR001882" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG11383" /db_xref="UniProtKB/Swiss-Prot:P49786" /translation="MLNIKEIHELIKAIDESTIDEFVYENEGVSLKLKKHEAGTVQVM QQAPAAPVQAQAPQAVQPQAQQAAAPAQEAPKQDENLHKITSPMVGTFYASSSPEAGP YVTAGSKVNENTVVCIVEAMKLFNEIEAEVKGEIVEVLVENGQLVEYGQPLFLVKAE* " /label="accB CDS" gene complement(2118771..2119250) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /label="accB gene" promotor_-10 complement(2119309..2119328) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2119320) /Source="Nicolas_upshifts" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2119342..2119349) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2119406..2120062) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15028710, 15752199, 16959571, 1766372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15028710, 15752199, 16959571, 1766372; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation ratchet engulfment protein" /protein_id="NP_390316.2" /db_xref="EnsemblGenomes-Gn:BSU24360" /db_xref="EnsemblGenomes-Tr:CAB14367" /db_xref="GOA:P49785" /db_xref="InterPro:IPR024232" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11415" /db_xref="UniProtKB/Swiss-Prot:P49785" /translation="MLKKQTVWLLTMLSLVVVLSVYYIMSPESKNAVQMQSEKSASDS GEVATEKAPAKQDTKEKSGTETEKGKEDGTKGTKDSSADKETSAEASEKGTVVTETAD DDLFTTYRLDLEDARSKEREELNAIVSSDDATAKEKSEAYDKMTALSEVEGTEKQLET LIKTQGYEDALVNAEGDKINITVKSDKHSKSKATAIIDLVAKEIKTMKDVAVTFEPSK *" /label="spoIIIAH CDS" gene complement(2119406..2120062) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /label="spoIIIAH gene" downshifts complement(2119413) /Source="Nicolas_upshifts" /id="D1270" /incds=0 /nref=26 /ntot=57 /MaxReadThrough="0.0903599999999987" /MaxDrop="6.40434" /score="21.0450747" /energy="-13" /TU="NA" /idTUdmin="U1899" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" CDS complement(2120063..2120752) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation engulfment assembly protein" /protein_id="NP_390317.2" /db_xref="EnsemblGenomes-Gn:BSU24370" /db_xref="EnsemblGenomes-Tr:CAB14368" /db_xref="GOA:P49784" /db_xref="InterPro:IPR014195" /db_xref="SubtiList:BG11414" /db_xref="UniProtKB/Swiss-Prot:P49784" /translation="MNKNGLWNVLKKQFLPGQTKDGEKPKLTKYHYFLFVFVLGVSFM LVSQLFSSPEKTENAKTITAVSSQHSADSKEKTAEVFKASKSDKPKDSIDDYEKEYEN QLKEILETIIGVDDVSVVVNVDATSLKVYEKNKSNKNTTTEETDKEGGKRSVTDQSSE EEIVMIKNGDKETPVVVQTKKPDIRGVLVVAQGVDNVQIKQTIIEAVTRVLDVPSHRV AVAPKKIKEDS*" /label="spoIIIAG CDS" gene complement(2120063..2120752) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /label="spoIIIAG gene" CDS complement(2120745..2121365) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390318.1" /db_xref="EnsemblGenomes-Gn:BSU24380" /db_xref="EnsemblGenomes-Tr:CAB14369" /db_xref="GOA:P49783" /db_xref="InterPro:IPR014245" /db_xref="SubtiList:BG11413" /db_xref="UniProtKB/Swiss-Prot:P49783" /translation="MSFLTEWLTTIVLFILFAIVIDMLLPSSSMQKYAKMVVSLLLIV VMLTPIFKLFKTDPEVIFEYLTKNGQSESADIKNQINSKKIEIQASQRAYILEEMAVQ LKKKAEERFSHDEYKVGRIKLTAGEKVDSEEDIKTISVYMAPSSEKTVQTVAPVHIDT DHAYVTKEAAEQKEAKQIQTQLADIWEIGSEKITVHMEGGESVGNE*" /label="spoIIIAF CDS" gene complement(2120745..2121365) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /label="spoIIIAF gene" promotor_-10 complement(2121071..2121089) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2121089) /Source="Nicolas_upshifts" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2121105..2121110) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2121379..2122578) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390319.2" /db_xref="EnsemblGenomes-Gn:BSU24390" /db_xref="EnsemblGenomes-Tr:CAB14370" /db_xref="GOA:P49782" /db_xref="InterPro:IPR014194" /db_xref="SubtiList:BG11412" /db_xref="UniProtKB/Swiss-Prot:P49782" /translation="MKRFQWVLLLAVLIIAGRAEIVQAAGNAEQTEDHAETAEQLAER TAASLETDKIGEFWNDIMTEYGGLLPESQKGSLMEFINGDKSFSPQEWLKALFSYLFH EVLANGKLLGTLILLTIFCVILQLLQNAFQQSTVSKVAYSIVYMVLIILALNSFHVAI NYATEAIQTMTSFILALIPLLLALLASSGGAVSAAFFHPVILFLMNTSGLLIQNIVMP LIFLSAILSIVSTMTEQYKVTQLANLLRNIAIGALAVFLTIFLGVISVQGASAAVTDG ITLRTAKFITGNFIPVLGRMFTDATDTVISASLLLKNTVGILGVAILICIAAFPAIKV LSLAFIYKLAAAILQPLGGGPVITCLDVISKSVIYIFAALAIVSLMFFLSLTVIITAG NLTMMMK*" /label="spoIIIAE CDS" gene complement(2121379..2122578) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /label="spoIIIAE gene" CDS complement(2122597..2122998) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390320.1" /db_xref="EnsemblGenomes-Gn:BSU24400" /db_xref="EnsemblGenomes-Tr:CAB14371" /db_xref="GOA:P49781" /db_xref="InterPro:IPR014211" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11411" /db_xref="UniProtKB/Swiss-Prot:P49781" /translation="MQIDIVQIVGLGLIATFLSLIVKEQKPTFAFLIVVFAGCAIFLY LVDQIYDIIRMIEKIAINANVNMVYVETILKIIGIAYIAEFGAQLTKDAGQGAIASKI ELAGKILILVMAVPILTVIIETILGLIPSMS*" /label="spoIIIAD CDS" gene complement(2122597..2122998) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /label="spoIIIAD gene" CDS complement(2123005..2123211) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390321.1" /db_xref="EnsemblGenomes-Gn:BSU24410" /db_xref="EnsemblGenomes-Tr:CAB14372" /db_xref="GOA:P49780" /db_xref="InterPro:IPR009570" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11410" /db_xref="UniProtKB/Swiss-Prot:P49780" /translation="MGVDVNVIFQIAGVGIVVAFLHTILDQMGKKEYAQWVTLLGFIY ILFMVATIVDDLFKKIKAVFLFQG*" /label="spoIIIAC CDS" gene complement(2123005..2123211) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /label="spoIIIAC gene" CDS complement(2123234..2123749) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390322.1" /db_xref="EnsemblGenomes-Gn:BSU24420" /db_xref="EnsemblGenomes-Tr:CAB14373" /db_xref="GOA:Q01368" /db_xref="InterPro:IPR014198" /db_xref="SubtiList:BG10541" /db_xref="UniProtKB/Swiss-Prot:Q01368" /translation="MLKLLGAVFIVVATTWTGFEMAKIYTERPRQIRQLRAALQSLEA EIMYGHTPLHTASQQIAKQLAQPVSTLFSAFSDQLDKGSDSAKTAWEQSLKKVWDTLS LKKSEYEVLKQFGETLGIHDRISQQKHIKLALTHLEASEADAEQAQAKNEKMIKSLGF LAGLLLILLLM*" /label="spoIIIAB CDS" gene complement(2123234..2123749) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /label="spoIIIAB gene" CDS complement(2123743..2124666) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATP-binding stage III sporulation protein" /protein_id="NP_390323.1" /db_xref="EnsemblGenomes-Gn:BSU24430" /db_xref="EnsemblGenomes-Tr:CAB14374" /db_xref="GOA:Q01367" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR014217" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10540" /db_xref="UniProtKB/Swiss-Prot:Q01367" /translation="MNEIAEVLPESMKNALSEIPEQQWLEIEEVRIRINRPVELIRRG QPVYLSYAGTAEDAHLILSRLSNYSMYTLEEELKKGYVTIRGGHRVGLAGRVITENGG VKGLRDIASFNIRIARQKLGIAEPLLPYLYQNSWLNTLIIGPPQTGKTTLLRDLARLS STGKKNMLPVKTGIVDERSEIAGCLRGIPQHQFGQRIDVLDACPKAEGLMMMIRSMSP EVMIVDEIGRMEDTDALLEALHAGVSVIVSAHGWSISDLMKRPSLKRLWEERAFDRYL ELSRAKGPGTVSQIYDKDGNVLSRTTGVKTC*" /label="spoIIIAA CDS" gene complement(2123743..2124666) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /label="spoIIIAA gene" S_feature complement(2124667..2124741) /Source="Nicolas_S_feature" /locus_tag="new_2537614_2537688_c" /HighExp="S3, LoTm, S4, T5.0H, M9-stat, S5, BT, S7, S6, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S919" CDS complement(2124742..2125023) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390324.1" /db_xref="EnsemblGenomes-Gn:BSU24440" /db_xref="EnsemblGenomes-Tr:CAB14375" /db_xref="GOA:P49779" /db_xref="InterPro:IPR020390" /db_xref="SubtiList:BG11459" /db_xref="UniProtKB/Swiss-Prot:P49779" /translation="MKFLLGNINSTVLTMAGLRVLSSMIELTAAIVMLVTNDVRKAVV VNSILAIVGPLIFIITMTVGIYQIAGQLSYAKLILIFTGVVLILAGVHK*" /label="yqhV CDS" gene complement(2124742..2125023) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /label="yqhV gene" promotor_-10 complement(2125043..2125061) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-10" upshifts complement(2125066) /Source="Nicolas_upshifts" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="upshifts" promotor_-35 complement(2125077..2125082) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-35" CDS complement(2125168..2125725) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor P" /protein_id="NP_390325.2" /db_xref="EnsemblGenomes-Gn:BSU24450" /db_xref="EnsemblGenomes-Tr:CAB14376" /db_xref="GOA:P49778" /db_xref="InterPro:IPR001059" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR011768" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013185" /db_xref="InterPro:IPR013852" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015365" /db_xref="InterPro:IPR020599" /db_xref="SubtiList:BG11460" /db_xref="UniProtKB/Swiss-Prot:P49778" /translation="MISVNDFRTGLTIEVDGGIWRVVDFQHVKPGKGAAFVRSKLRNL RTGAIQEKTFRAGEKVAKAQIETKTMQYLYANGDQHVFMDTSSYEQLELSATQIEEEL KYLLENMSVHIMMYQDETLGIELPNTVELKVVETEPGIKGDTASGGTKPAKTETGLVV NVPFFVNEGDTLVVNTSDGSYVSRA*" /label="efp CDS" gene complement(2125168..2125725) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /label="efp gene" downshifts complement(2125180) /Source="Nicolas_upshifts" /id="D1271" /incds=0 /nref=256 /ntot=266 /MaxReadThrough="0.83852" /MaxDrop="7.73118" /score="27.4193827" /energy="-13.5" /TU="NA" /idTUdmin="U1901" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2125750..2126811) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /EC_number="3.4.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23144141, 26735940, 27002156" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23144141, 26735940, 27002156; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase (Met-Xaa and Xaa-Pro, Xaa-Pro-Xaa)" /protein_id="NP_390326.1" /db_xref="EnsemblGenomes-Gn:BSU24460" /db_xref="EnsemblGenomes-Tr:CAB14377" /db_xref="GOA:P54518" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG11708" /db_xref="UniProtKB/Swiss-Prot:P54518" /translation="MKLEKLRNLFGQLGIDGMLITSNTNVRYMTGFTGSAGLAVISGD KAAFITDFRYTEQAKVQVKGFEIIEHGGSLIQTTADTVESFGIKRLGFEQNSMTYGTY ASYSAVISDAELVPVAESVEKLRLIKSSEEIKILEEAAKIADDAFRHILTFMKPGISE IAVANELEFYMRSQGADSSSFDMIVASGLRSSLPHGVASDKLIESGDLVTLDFGAYYK GYCSDITRTVAVGQPSDQLKEIYQVVFDAQALGVAHIKPGMTGKEADALTRDHIAAKG YGDYFGHSTGHGLGMEVHESPGLSVRSSAILEPGMVVTVEPGIYIPETGGVRIEDDIV ITENGNRTITHSPKELIIL*" /label="papA CDS" gene complement(2125750..2126811) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /label="papA gene" CDS complement(2126808..2127254) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10870960, 19099550; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase, type II" /protein_id="NP_390327.1" /db_xref="EnsemblGenomes-Gn:BSU24470" /db_xref="EnsemblGenomes-Tr:CAB14378" /db_xref="GOA:P54517" /db_xref="InterPro:IPR001874" /db_xref="InterPro:IPR018509" /db_xref="InterPro:IPR036441" /db_xref="PDB:1GQO" /db_xref="SubtiList:BG11707" /db_xref="UniProtKB/Swiss-Prot:P54517" /translation="MPHFLILNGPNVNRLGSREPEVFGRQTLTDIETDLFQFAEALHI QLTFFQSNHEGDLIDAIHEAEEQYSGIVLNPGALSHYSYAIRDAVSSISLPVVEVHLS NLYAREEFRHQSVIAPVAKGQIVGLGAEGYKLAVRYLLSQQGGESR*" /label="yqhS CDS" gene complement(2126808..2127254) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /label="yqhS gene" promotor_-10 complement(2127303..2127322) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2127319) /Source="Nicolas_upshifts" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2127335..2127342) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2127341..2127877) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390328.1" /db_xref="EnsemblGenomes-Gn:BSU24480" /db_xref="EnsemblGenomes-Tr:CAB14379" /db_xref="GOA:P54516" /db_xref="InterPro:IPR024563" /db_xref="SubtiList:BG11706" /db_xref="UniProtKB/Swiss-Prot:P54516" /translation="MMTSEKDTEQNEELNEKQKPPVSMAGRVAATGFCGGVLWSFVAY IAYLFHFSEISPNMILQPFVLGEWKKHGLGTVISIILIGVISIGAAFLYFLLLKRLKT MWPGILYGLVLWLLVFFVFNPIFPDVRTVTELTSDTIITTICIYLLYGLFVGYSISFE YNELNSEKLARALGMHRE*" /label="yqhR CDS" gene complement(2127341..2127877) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /label="yqhR gene" promotor_-10 complement(2127890..2127901) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-10" upshifts complement(2127899) /Source="Nicolas_upshifts" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="upshifts" promotor_-35 complement(2127915..2127921) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-35" promotor_-35 2127947..2127953 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2127966 /Source="Nicolas_upshifts" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2127968..2127986 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2128023..2128026 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2128041..2128060 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2128052 /Source="Nicolas_upshifts" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="upshifts" CDS 2128104..2129060 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390329.2" /db_xref="EnsemblGenomes-Gn:BSU24490" /db_xref="EnsemblGenomes-Tr:CAB14380" /db_xref="GOA:P54515" /db_xref="InterPro:IPR010787" /db_xref="SubtiList:BG11705" /db_xref="UniProtKB/Swiss-Prot:P54515" /translation="MSKHKVPPAYGGQAVVEGVMFGGKHHYVTAIRRTDGSIDFFKLP RKHNPKLNIVKKIPFLRGIAAIIEASANGTKHLNFSSERYGLDPSEDETLEQEEKKSS GLSMYLSLAVIGVLSFLFSKFVFTLVPVFLAELTRPIFSLNTAQIAIESLFKLILLLG YIYFLSMTPLIKRVFQYHGAEHKVINCYEQNLPITVENVQNQSRLHYRCGSSFILFTI IVGMFVYLLVPTDPLWLRVIDRVALIPVVLGISFEVLQLTNKVRDIPGLKLLGYPGLW LQLLTTKEPKDEQVEVAIESFNELLRLEALSEQNQKPSHNVI*" /label="yqhQ CDS" gene 2128104..2129060 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /label="yqhQ gene" CDS 2129100..2129495 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390330.1" /db_xref="EnsemblGenomes-Gn:BSU24500" /db_xref="EnsemblGenomes-Tr:CAB14381" /db_xref="GOA:P54514" /db_xref="SubtiList:BG11704" /db_xref="UniProtKB/Swiss-Prot:P54514" /translation="MNHRVQPIIAVLIALGAFGFLYVLVTNPGEMAKMAVTVIVAGII IYFIVKYVMNRNAGSEGAAFKKAAKQSRRRMKEQKAKHRAGHKGRVSHLRSVPSASKP KPMILKKKSQTQLTVIEGKKNKKKNRALF*" /label="yqhP CDS" gene 2129100..2129495 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /label="yqhP gene" promotor_no_box 2129378..2129478 /Source="Nicolas_upshift_promotors" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2129438 /Source="Nicolas_upshifts" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2129481 /Source="Nicolas_upshifts" /id="D1272" /incds=0 /nref=116 /ntot=283 /MaxReadThrough="2.23161" /MaxDrop="5.94415" /score="29.0609078" /energy="-8" /TU="NA" /idTUdmin="U1903" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2129492..2130367) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipase / acyl esterase" /protein_id="NP_390331.1" /db_xref="EnsemblGenomes-Gn:BSU24510" /db_xref="EnsemblGenomes-Tr:CAB14382" /db_xref="GOA:P54513" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG11703" /db_xref="UniProtKB/Swiss-Prot:P54513" /translation="MYIDGVFSGGGVKGIALAGAYEVLEEKGFRFKRVAGTSAGAIIA AFIASGYTSKEIHALIEEVDGEKLLDQRYSFLPLKMLQWVSIYWRLGLYKGDTIEKWI ADLLRAKGIRVFGDLQKGSLRLIASDLTNGTMIVLPDDLARYGLNPDMFPVARAVRMS CSIPYFFEPIKLKTDTGTATVVDGGVLSNFPIWLFSKERKRPVIGVTLAPRERERPKK NIRNAFELFGALFETMKDAHDARHIASRYEQNIIFLPVDDVMATDFHLTQQKKLALIE LGKRRTELFLKQWTY*" /label="yqhO CDS" gene complement(2129492..2130367) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /label="yqhO gene" promotor_-10 complement(2130394..2130412) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2130411) /Source="Nicolas_upshifts" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2130428..2130433) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2130493..2130921) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (hydrogen peroxide sensing, allosterically regulated by Mn2+)" /protein_id="NP_390332.2" /db_xref="EnsemblGenomes-Gn:BSU24520" /db_xref="EnsemblGenomes-Tr:CAB14383" /db_xref="GOA:P54512" /db_xref="InterPro:IPR001367" /db_xref="InterPro:IPR022687" /db_xref="InterPro:IPR022689" /db_xref="InterPro:IPR022897" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036421" /db_xref="PDB:1ON1" /db_xref="PDB:1ON2" /db_xref="PDB:2EV0" /db_xref="PDB:2EV5" /db_xref="PDB:2EV6" /db_xref="PDB:2F5C" /db_xref="PDB:2F5D" /db_xref="PDB:2F5E" /db_xref="PDB:2F5F" /db_xref="PDB:2HYF" /db_xref="PDB:2HYG" /db_xref="PDB:3R60" /db_xref="PDB:3R61" /db_xref="PDB:4HV5" /db_xref="PDB:4HV6" /db_xref="PDB:4HX4" /db_xref="PDB:4HX7" /db_xref="PDB:4HX8" /db_xref="SubtiList:BG11702" /db_xref="UniProtKB/Swiss-Prot:P54512" /translation="MTTPSMEDYIEQIYMLIEEKGYARVSDIAEALAVHPSSVTKMVQ KLDKDEYLIYEKYRGLVLTSKGKKIGKRLVYRHELLEQFLRIIGVDEEKIYNDVEGIE HHLSWNSIDRIGDLVQYFEEDDARKKDLKSIQKKTEHHNQ*" /label="mntR CDS" gene complement(2130493..2130921) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /label="mntR gene" downshifts complement(2130520) /Source="Nicolas_upshifts" /id="D1273" /incds=0 /nref=322 /ntot=333 /MaxReadThrough="2.568" /MaxDrop="7.28707" /score="15.888362" /energy="-12" /TU="NA" /idTUdmin="U1908" /TUdmin=6 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2130956..2130975) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2130964) /Source="Nicolas_upshifts" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2130991..2130995) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2131021..2131857) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /EC_number="2.3.1.181" /function="3: Fatty acid and phospholipid metabolism" /experiment="publication(s) with functional evidences, PMID:20882995, 21338420, 21338421, 23960015" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20882995, 21338420, 21338421, 23960015; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein octanoyltransferase" /protein_id="NP_390333.1" /db_xref="EnsemblGenomes-Gn:BSU24530" /db_xref="EnsemblGenomes-Tr:CAB14384" /db_xref="GOA:P54511" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024898" /db_xref="SubtiList:BG11701" /db_xref="UniProtKB/Swiss-Prot:P54511" /translation="MQKETWRFIDSGNASPAFNMALDEALLYWHSEKKIPPVIRFYGW NPATLSVGYFQNIKKEINFEAVHKYNLGFVRRPTGGRGVLHDQELTYSVIVSEEHPEM PATVTEAYRVISEGILQGFRNLGLDAYFAIPRTEKEKESLKNPRSSVCFDAPSWYELV VEGRKVAGSAQTRQKGVILQHGSILLDLDEDKLFDLFLYPSERVRERMQRNFKNKAVA INELIEKRVTMDEARKAFKEGFETGLNIHLEPYELSQEELDFVHHLAETKYASDEWNY KR*" /label="lipM CDS" gene complement(2131021..2131857) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /label="lipM gene" promotor_-10 complement(2131881..2131900) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2131892) /Source="Nicolas_upshifts" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2131894..2132438) /Source="Nicolas_S_feature" /locus_tag="new_2544841_2545385_c" /HighExp="Lbstat, LPhT, HiOs, M0t90, S1, M40t90, Sw, S0, B36, BC" /AntisenseName="yqhL" /AntisenseCor="-0.136624541005539" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S920" promotor_-35 complement(2131914..2131921) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2131938..2131943 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2131957..2131976 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2131957 /Source="Nicolas_upshifts" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="upshifts" S_feature 2131968..2132047 /Source="Nicolas_S_feature" /locus_tag="new_2544915_2544994" /HighExp="dia15, H2O2, dia5, Diami, MG-0.2, G180, UNK1, LBGexp, Heat, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S921" CDS 2132048..2132428 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11092948; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390334.2" /db_xref="EnsemblGenomes-Gn:BSU24540" /db_xref="EnsemblGenomes-Tr:CAB14385" /db_xref="GOA:P54510" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11700" /db_xref="UniProtKB/Swiss-Prot:P54510" /translation="MSNMIVLIIFAAFIIYMIASYVYQQRIMKTLTEEEFRAGYRKAQ LIDVREPNEFEGGHILGARNIPLSQLKQRKNEIRTDKPVYLYCQNSVRSGRAAQTLRK NGCTEIYNLKGGFKKWGGKIKAKK*" /label="yqhL CDS" gene 2132048..2132428 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /label="yqhL gene" downshifts 2132364 /Source="Nicolas_upshifts" /id="D1274" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17088" /MaxDrop="3.92673" /score="27.1863605" /energy="-12" /TU="U1909" /idTUdmin="U1909" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 2132408 /Source="Nicolas_upshifts" /id="D1275" /incds=0 /nref=213 /ntot=249 /MaxReadThrough="2.26861" /MaxDrop="6.03848" /score="27.1863605" /energy="-12" /TU="NA" /idTUdmin="U1909" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2132463..2133929) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8181752, 20011599, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8181752, 20011599, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 2) (glycine cleavage system protein P)" /protein_id="NP_390335.1" /db_xref="EnsemblGenomes-Gn:BSU24550" /db_xref="EnsemblGenomes-Tr:CAB14386" /db_xref="GOA:P54377" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023012" /db_xref="SubtiList:BG11511" /db_xref="UniProtKB/Swiss-Prot:P54377" /translation="MSNQDQALIFELSREGRIGYSLPELDVPEIELGDLLSDTYIRDE DAALPEVSELDIMRHYTALSKRNHGVDSGFYPLGSCTMKYNPKINEKIARIPGFAAIH PLQDEDTVQGALELLYDLSKHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAYHEARGD FKRTKVIVPDSAHGTNPASATVAGFETVTVKSNEKGLVDLEDLKRAVNEETAALMLTN PNTLGLFEEQITEMAEIVHQAGGKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFT GPHGGGGPGSGPVGVKQDLIPYLPKPVLVKKEGRFTFDYDRPHAIGRVKPYYGNFGIN VRAYTYIRSMGPDGLKAVTENAVLNANYMMRKLAPYYDLPFDRHCKHEFVLSGKRQKK LGVRTLDIAKRLLDFGYHPPTIYFPLNVEECIMIEPTETESKETLDAFIDAMIQIAKE AEENPELVQEAPHTTIVKRMDETKAARHPVLRYEAEER*" /label="gcvPB CDS" gene complement(2132463..2133929) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /label="gcvPB gene" downshifts complement(2132483) /Source="Nicolas_upshifts" /id="D1276" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="3.45831" /MaxDrop="4.3142" /score="0.884126414" /energy="-12" /TU="U1911" /idTUdmin="U1911" /TUdmin="-1517" /isTUend="FALSE" /label="downshifts" CDS complement(2133922..2135268) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8181752, 20011599, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 1) (glycine cleavage system protein P)" /protein_id="NP_390336.2" /db_xref="EnsemblGenomes-Gn:BSU24560" /db_xref="EnsemblGenomes-Tr:CAB14387" /db_xref="GOA:P54376" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023010" /db_xref="SubtiList:BG11510" /db_xref="UniProtKB/Swiss-Prot:P54376" /translation="MKHRYLPATEKDKQEMLATIGVSSIDDLFADIPENVKYKKEHQI KKAKSETELTRELTKLASKNRDTVQYASFLGAGVYDHYQPVIVDHVISRSEFYTAYTP YQPEISQGELQAIFEFQTMICELTGMDIANSSMYDGGTALAEAAMLASGHTKKKKIVV SKTVHPESREVLKTYAKGQYIDVVEVPAADGVTDLDALRQTVCENTAAVIVQYPNFFG RIEPLKDIEPIAHQGKSMFIVSANPLALGLLTPPGKFQSDIVVGDAQPFGIPSAYGGP HCGFFAVTKKLMRKVPGRLVGQTEDENGKRGFVLTLQAREQHIRRDKATSNICSNQAL NALAASVAMTALGKNGVKDIARQNLLKANYAKQEAKKAGLTVMFDGPMFNEFVIKLDE PVRAVNKRLLAKGMIGGYDLGLTYPELDCHMLIAVTELRTKEEIDALIQELGDRHE*" /label="gcvPA CDS" gene complement(2133922..2135268) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /label="gcvPA gene" CDS complement(2135298..2136386) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /EC_number="2.1.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8219277, 15472076, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8219277, 15472076, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminomethyltransferase (glycine cleavage system protein T)" /protein_id="NP_390337.2" /db_xref="EnsemblGenomes-Gn:BSU24570" /db_xref="EnsemblGenomes-Tr:CAB14388" /db_xref="GOA:P54378" /db_xref="InterPro:IPR006222" /db_xref="InterPro:IPR006223" /db_xref="InterPro:IPR013977" /db_xref="InterPro:IPR022903" /db_xref="InterPro:IPR028896" /db_xref="InterPro:IPR029043" /db_xref="PDB:1YX2" /db_xref="SubtiList:BG11509" /db_xref="UniProtKB/Swiss-Prot:P54378" /translation="MLKRTPLFDLYKEYGGKTIDFGGWELPVQFSSIKKEHEAVRTAA GLFDVSHMGEVEVSGNDSLSFLQRLMTNDVSALTPGRAQYTAMCYPDGGTVDDLLIYQ KGENRYLLVINASNIDKDLAWMKEHAAGDVQIDNQSDQIALLAVQGPKAEAILKNLTD ADVSALKPFAFIDEADISGRKALISRTGYTGEDGYEIYCRSDDAMHIWKKIIDAGDAY GLIPCGLGARDTLRFEAKLPLYGQELTRDITPIEAGIGFAVKHKKESDFFGKSVLSEQ KENGAKRKLVGLEMIEKGIPRHGYEVFQNGKSVGKVTTGTQSPTLGKNVGLALIDSET SEIGTVVDVEIRKKLVKAKVVKTPFYKR*" /label="gcvT CDS" gene complement(2135298..2136386) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /label="gcvT gene" misc_RNA complement(2136460..2136659) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /product="dual aptamer glycine riboswitch" /experiment="publication(s) with functional evidences, PMID:15472076, 21439473, 23249744, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15472076, 21439473, 23249744, 23721735, 29089431; Product type n: RNA" /label="swgA RNA" gene complement(2136460..2136659) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /label="swgA gene" downshifts complement(2136510) /Source="Nicolas_upshifts" /id="D1277" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="6.79606" /MaxDrop="3.0322" /score="21.5485037" /energy="-20.2" /TU="U1911" /idTUdmin="U1915" /TUdmin=3630 /isTUend="FALSE" /label="downshifts" S_feature complement(2136660..2136730) /Source="Nicolas_S_feature" /locus_tag="new_2549607_2549677_c" /HighExp="B60, S8, S6, B36, S7, M9-stat, Sw, T3.0H, HiOs, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S922" promotor_-35 2136663..2136668 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2136684..2136702 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2136688 /Source="Nicolas_upshifts" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="upshifts" S_feature 2136698..2136827 /Source="Nicolas_S_feature" /locus_tag="new_2549645_2549774" /HighExp="S4, S8, S7, S3, S5, S6, LoTm, T5.0H, T4.0H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.83" /TUlongSig="NA" /TUlongPSig="NA" /label="S923" promotor_-10 complement(2136716..2136735) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-10" upshifts complement(2136730) /Source="Nicolas_upshifts" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="upshifts" promotor_-35 complement(2136749..2136756) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-35" CDS 2136828..2138501 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /EC_number="3.6.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA polymerase-associated helicase protein" /protein_id="NP_390338.1" /db_xref="EnsemblGenomes-Gn:BSU24580" /db_xref="EnsemblGenomes-Tr:CAB14389" /db_xref="GOA:P54509" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11699" /db_xref="UniProtKB/Swiss-Prot:P54509" /translation="MNTEMIYDAKWPEEFAERLKNDGPWANWELYKLSAEIQKTLAIP EFEGLRAPLYLPSFTPLPHQLEVAQKVVEKMNGKAILADEVGLGKTVEAGLILKEYMI RGLAKKILILVPASLVSQWVKELQEKFLIPAVEQKKSYVWEQCDIVVSSIDTAKRSPH REIVLSIPYDLVIIDEAHKLKNSKTKNYEFVRNLVKKYCLLLTATPIQNRIEEIFNLV SLLKPGHLGSQNHFQEEFAKKKSSLEAHEHLKDLVNKVMIRNRRHDTGLNWKQRHVET VPIQFSPSEQALYDEISRLKDSINKPASMFSIMTLQRECCSSREAVYMTLKKMLDQKE KQAPAIDEDTISVLIDRINQVTQNSKALQVVDLIKKIDDKVIIFTEYRATQIYLQWFL QQNGISSVPFRGGFKRGKKDWMKDLFRGKIQVLIATEAGGEGINLQFCNHMINYDLPW NPMRLEQRIGRIHRLGQERDVHIYNMATKHTVEEHILKLLYEKIHLFEKVVGELDDIL TKIQVNNFEEHLHDILYHSATEEEMKIKMDNLTSFLSYKKQLPAEKRGS*" /label="yqhH CDS" gene 2136828..2138501 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /label="yqhH gene" CDS 2138522..2139316 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390339.1" /db_xref="EnsemblGenomes-Gn:BSU24590" /db_xref="EnsemblGenomes-Tr:CAB14390" /db_xref="InterPro:IPR024562" /db_xref="SubtiList:BG11698" /db_xref="UniProtKB/Swiss-Prot:P54508" /translation="MRQQEVHDFLLRFFQANSCQIVDQGLGYMTVQLTVEMDKQIMNR PFYWHWREKTGGDPNPMKITFITDKENAPKDLDGEFIYFGAPRLFQIFKAVKQNGRFT RMYEKIESAGAKVPLQPWLGINVTISYQSDMKKDKLLSLGLHLVSGTIIEDFQSKLTQ FSLTSQICDYCFTISPMIKPESGLKRMENYISKSAMQEPSDWAEQAVNRWKNDMTLLD KFYEHIEEKPEEYHLEKQALKTLYQPKISVEIENGGLFYLQNNISS*" /label="yqhG CDS" gene 2138522..2139316 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /label="yqhG gene" misc_feature 2138852..2138853 /Source="Nicolas_upshift_promotors" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2138858 /Source="Nicolas_upshifts" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="upshifts" promotor_-35 2139340..2139343 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2139359..2139378 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2139360..2139498 /Source="Nicolas_S_feature" /locus_tag="new_2552307_2552445" /HighExp="LoTm, S4, S5, T5.0H, M9-stat, S3, B60, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.843, 0.83" /TUlongSig="SigA" /TUlongPSig="0.541" /label="S924" upshifts 2139360 /Source="Nicolas_upshifts" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="upshifts" CDS 2139499..2139672 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antagonist of SinR" /protein_id="NP_390340.1" /db_xref="EnsemblGenomes-Gn:BSU24600" /db_xref="EnsemblGenomes-Tr:CAB14391" /db_xref="GOA:P23308" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="SubtiList:BG10753" /db_xref="UniProtKB/Swiss-Prot:P23308" /translation="MKNAKQEHFELDQEWVELMVEAKEANISPEEIRKYLLLNKKSAH PGPAARSHTVNPF*" /label="sinI CDS" gene 2139499..2139672 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /label="sinI gene" promotor_-35 2139657..2139661 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2139674..2139693 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2139674 /Source="Nicolas_upshifts" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="upshifts" CDS 2139706..2140041 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator of biofilm formation" /protein_id="NP_390341.1" /db_xref="EnsemblGenomes-Gn:BSU24610" /db_xref="EnsemblGenomes-Tr:CAB14392" /db_xref="GOA:P06533" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="PDB:2YAL" /db_xref="PDB:3QQ6" /db_xref="PDB:3ZKC" /db_xref="SubtiList:BG10754" /db_xref="UniProtKB/Swiss-Prot:P06533" /translation="MIGQRIKQYRKEKGYSLSELAEKAGVAKSYLSSIERNLQTNPSI QFLEKVSAVLDVSVHTLLDEKHETEYDGQLDSEWEKLVRDAMTSGVSKKQFREFLDYQ KWRKSQKEE*" /label="sinR CDS" gene 2139706..2140041 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /label="sinR gene" downshifts 2140018 /Source="Nicolas_upshifts" /id="D1278" /incds=0 /nref=21 /ntot=181 /MaxReadThrough="4.7611" /MaxDrop="6.41889" /score="2.30357781" /energy="-20" /TU="U1913,U1914" /idTUdmin="U1910" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts 2140108 /Source="Nicolas_upshifts" /id="D1279" /incds=0 /nref=1 /ntot=85 /MaxReadThrough="2.4376" /MaxDrop="4.25363" /score="58.1462301" /energy="-26.8" /TU="NA" /idTUdmin="U1913" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts complement(2140140) /Source="Nicolas_upshifts" /id="D1280" /incds=0 /nref=144 /ntot=227 /MaxReadThrough="4.33009" /MaxDrop="8.70948" /score="10.0483516" /energy="-20" /TU="NA" /idTUdmin="U1915" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(2140157,2140164) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs27" N_region 2140158..2140163 /note="SacI site (GAGCTC)" /created_by="User" /label="IIG_Bs27" promotor_-35 2140233..2140239 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2140240 /Source="Nicolas_upshifts" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2140253..2140264 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2140283..2140609 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390345.1" /db_xref="EnsemblGenomes-Gn:BSU24650" /db_xref="EnsemblGenomes-Tr:CAB14396" /db_xref="InterPro:IPR024987" /db_xref="PDB:2LYX" /db_xref="SubtiList:BG13773" /db_xref="UniProtKB/Swiss-Prot:O32019" /translation="MMIKQCVICLSLLVFGTTAAHAEETPLVTARHMSKWEEIAVKEA KKRYPLAQVLFKQKVWDRKRKDEAVKQYHLTLREGSKEFGVFVTISFDPYSQKVNKIA ILEEYQ*" /label="yqzG CDS" gene 2140283..2140609 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /label="yqzG gene" S_feature complement(2140426..2140650) /Source="Nicolas_S_feature" /locus_tag="new_2555662_2555886_c" /HighExp="GM 150, G/S, C30, T-4.40H, S8, T-3.40H, Pyr, S7, S2, C90" /AntisenseName="yqzG" /AntisenseCor="0.536702817178903" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.549, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S925" downshifts complement(2140469) /Source="Nicolas_upshifts" /id="D1281" /incds=1 /nref=92 /ntot=160 /MaxReadThrough="2.23218" /MaxDrop="5.56661" /score="31.27773" /energy="-10.2" /TU="NA" /idTUdmin="U1918" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2140591 /Source="Nicolas_upshifts" /id="D1282" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="2.14107" /MaxDrop="4.98052" /score="-9.62570043" /energy="-15.1" /TU="NA" /idTUdmin="U1917" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2140651..2140830) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="factor involved in sporulation" /protein_id="NP_390346.2" /db_xref="EnsemblGenomes-Gn:BSU24660" /db_xref="EnsemblGenomes-Tr:CAB14397" /db_xref="InterPro:IPR025622" /db_xref="SubtiList:BG13771" /db_xref="UniProtKB/Swiss-Prot:O32020" /translation="MKTNDYVKYMTQQFVKYIDTPRDERKERKEVRKETKTPVSQQWF GILPYGFRLWLKRKK*" /label="spoIIT CDS" gene complement(2140651..2140830) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /label="spoIIT gene" promotor_-10 complement(2140849..2140867) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2140864) /Source="Nicolas_upshifts" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2140882..2140888) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2140901..2141275) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406, 24164455; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390347.1" /db_xref="EnsemblGenomes-Gn:BSU24670" /db_xref="EnsemblGenomes-Tr:CAB14398" /db_xref="GOA:P25959" /db_xref="InterPro:IPR020372" /db_xref="SubtiList:BG10489" /db_xref="UniProtKB/Swiss-Prot:P25959" /translation="MYRTRGFIYPAVLFVSALVLLIVNFVAAQYISRCMFEKETKELY IGENLLQNGVLLSIRHVLEERKGQEGTQQFLYGRVSYYIHDTSIKEQKEINLRVSTDS GTERTAQIVFDQKQKKLLRWTE*" /label="comGG CDS" gene complement(2140901..2141275) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /label="comGG gene" CDS complement(2141276..2141659) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390348.1" /db_xref="EnsemblGenomes-Gn:BSU24680" /db_xref="EnsemblGenomes-Tr:CAB14399" /db_xref="GOA:P25958" /db_xref="InterPro:IPR016977" /db_xref="SubtiList:BG10488" /db_xref="UniProtKB/Swiss-Prot:P25958" /translation="MLISGSLAAIIHLFLSRQQEHDGFTQQEWMISIEQMMNECKESQ AVKTAEHGSVLICTNLSGQDIRFDIYHSMIRKRVDGKGHVPILDHITAMKADIENGVV LLKIESEDQKVYQTAFPVYSYLGGG*" /label="comGF CDS" gene complement(2141276..2141659) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /label="comGF gene" CDS complement(2141685..2142032) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /function="16.11: Scavenge (Catabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7783624, 9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390349.1" /db_xref="EnsemblGenomes-Gn:BSU24690" /db_xref="EnsemblGenomes-Tr:CAB14400" /db_xref="GOA:P25957" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR020488" /db_xref="SubtiList:BG10487" /db_xref="UniProtKB/Swiss-Prot:P25957" /translation="MWRENKGFSTIETMSALSLWLFVLLTVVPLWDKLMADEKMAESR EIGYQMMNESISKYVMSGEGAASKTITKNNHIYAMKWEEEGEYQNVCIKAAAYKEKSF CLSILQTEWLHAS*" /label="comGE CDS" gene complement(2141685..2142032) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /label="comGE gene" CDS complement(2142016..2142447) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane component of the DNA transport pilin platform" /protein_id="NP_390350.1" /db_xref="EnsemblGenomes-Gn:BSU24700" /db_xref="EnsemblGenomes-Tr:CAB14401" /db_xref="GOA:P25956" /db_xref="InterPro:IPR002416" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016785" /db_xref="SubtiList:BG10486" /db_xref="UniProtKB/Swiss-Prot:P25956" /translation="MNIKLNEEKGFTLLESLLVLSLASILLVAVFTTLPPAYDNTAVR QAASQLKNDIMLTQQTAISRQQRTKILFHKKEYQLVIGDTVIERPYATGLSIELLTLK DRLEFNEKGHPNAGGKIRVKGHAVYDITVYLGSGRVNVERK*" /label="comGD CDS" gene complement(2142016..2142447) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /label="comGD gene" CDS complement(2142437..2142733) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="pilin-like component of the DNA transport membrane pilin platform" /protein_id="NP_390351.1" /db_xref="EnsemblGenomes-Gn:BSU24710" /db_xref="EnsemblGenomes-Tr:CAB14402" /db_xref="GOA:P25955" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016940" /db_xref="SubtiList:BG10485" /db_xref="UniProtKB/Swiss-Prot:P25955" /translation="MNEKGFTLVEMLIVLFIISILLLITIPNVTKHNQTIQKKGCEGL QNMVKAQMTAFELDHEGQTPSLADLQSEGYVKKDAVCPNGKRIIITGGEVKVEH*" /label="comGC CDS" gene complement(2142437..2142733) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /label="comGC gene" CDS complement(2142747..2143718) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 15968048, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 15968048, 16850406, 24164455; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane pilin platform component of the DNA transport machinery" /protein_id="NP_390352.1" /db_xref="EnsemblGenomes-Gn:BSU24720" /db_xref="EnsemblGenomes-Tr:CAB14403" /db_xref="GOA:P25954" /db_xref="InterPro:IPR001992" /db_xref="InterPro:IPR018076" /db_xref="SubtiList:BG10484" /db_xref="UniProtKB/Swiss-Prot:P25954" /translation="MTAGGYTLLDGLRLMELQMNKRQAADLTDSVTCLREGAPFYQVL KSLSFHKEAVGICYFAETHGELPASMIQSGELLERKIAQADQLKRVLRYPLFLIFTVA VMFYMLQSIIIPQFSGIYQSMNMETSRSTDMLFAFFQHIDLVIILLVLFTAGIGIYYW LVFKKKSPARQMLICIRIPLVGKLVKLFNSYFFSLQLSSLLKSGLSIYDSLNAFKHQT FLPFYRCEAEQLIERLKAGESIESAICGSLFYETDLSKVISHGQLSGRLDRELFTYSQ FILQRLEHKAQKWTGILQPMIYGFVAAMILLVYLSMLVPMYQMMNQM*" /label="comGB CDS" gene complement(2142747..2143718) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /label="comGB gene" CDS complement(2143771..2144841) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane associated ATPase of the pilin platformfor DNA competence" /protein_id="NP_390353.1" /db_xref="EnsemblGenomes-Gn:BSU24730" /db_xref="EnsemblGenomes-Tr:CAB14404" /db_xref="GOA:P25953" /db_xref="InterPro:IPR001482" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10483" /db_xref="UniProtKB/Swiss-Prot:P25953" /translation="MDSIEKVSKNLIEEAYLTKASDIHIVPRERDAIIHFRVDHALLK KRDMKKEECVRLISHFKFLSAMDIGERRKPQNGSLTLKLKEGNVHLRMSTLPTINEES LVIRVMPQYNIPSIDKLSLFPKTGATLLSFLKHSHGMLIFTGPTGSGKTTTLYSLVQY AKKHFNRNIVTLEDPVETRDEDVLQVQVNEKAGVTYSAGLKAILRHDPDMIILGEIRD AETAEIAVRAAMTGHLVLTSLHTRDAKGAIYRLLEFGINMNEIEQTVIAIAAQRLVDL ACPFCENGCSSVYCRQSRNTRRASVYELLYGKNLQQCIQEAKGNHANYQYQTLRQIIR KGIALGYLTTNNYDRWVYHEKD*" /label="comGA CDS" gene complement(2143771..2144841) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /label="comGA gene" promotor_-10 complement(2144859..2144878) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2144875) /Source="Nicolas_upshifts" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2144892..2144899) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2145024..2145252) /Source="Nicolas_S_feature" /locus_tag="new_2560260_2560488_c" /HighExp="Etha, Salt, Sw, Gly, LPhT, B36, Heat, B60, LoTm, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37350499999999998" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S926" downshifts complement(2145065) /Source="Nicolas_upshifts" /id="D1283" /incds=0 /nref=16 /ntot=42 /MaxReadThrough="0.95925" /MaxDrop="5.92871" /score="30.7083619" /energy="-13" /TU="NA" /idTUdmin="U1920" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2145253..2146206) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15856219, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15856219, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="CorA-type divalent ion transporter" /protein_id="NP_390354.1" /db_xref="EnsemblGenomes-Gn:BSU24740" /db_xref="EnsemblGenomes-Tr:CAB14405" /db_xref="GOA:P40948" /db_xref="InterPro:IPR002523" /db_xref="SubtiList:BG11075" /db_xref="UniProtKB/Swiss-Prot:P40948" /translation="MKAHTGKDWFWYQMGPQERSKARDLIHFSHWPQCEKWFENNHHV NFLRVDTTETENEAVFGSIVYDQGLGEEKDHTVFHFYITRQYFFTINFDFSILREIKG KEVVRQMERADNAIEGFLILLGELMNAYLIGVDEFEVKLRKLRWQIKDDNSKSILNRV HLLRHELMIWKNLILSAKKIEMALKETFLPQNEGKKDYQRTQLKIDRGFTYISEFEGE LNNLLHSEEVITSHRGNEIVKALTIFTTLFTPITALGALWGMNFSVMPELNWKYGYLF SLLLIVTSTVLIYLYLRKKGWTGDMLQERKKKKKPRKRRTL*" /label="yqxL CDS" gene complement(2145253..2146206) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /label="yqxL gene" promotor_-10 complement(2146230..2146249) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2146251) /Source="Nicolas_upshifts" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2146263..2146269) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2146289..2146295 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2146310..2146328 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2146328 /Source="Nicolas_upshifts" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="upshifts" CDS 2146349..2147677 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane associated enzyme" /protein_id="NP_390355.1" /db_xref="EnsemblGenomes-Gn:BSU24750" /db_xref="EnsemblGenomes-Tr:CAB14406" /db_xref="GOA:P54505" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG11695" /db_xref="UniProtKB/Swiss-Prot:P54505" /translation="MPSLEKAVVLEFINLLAVAILILLTGFFVAVEFSIVKVRRSKID QLVAKGKKGAKAAKHVITHLDEYLSACQLGITVAALGLGWLGEPTVQTLLRPLFHKAG LNESLTHLLSLVIAFLVVTYLNVVIGELAPKSFAIQKAESITLLFAKPLIWFYKIMFP FIWLLNHSARLITGVFGLKPASEHELAYTEEELRVLLAESYKSGEIRKSELKYMNNIF TFDKRMAKEIMVPRNEMVSLSLDEDSISNLQETVKQTKYTRYPVVREDKDNVIGVINM KEVLFSMLTKDFSIKKHQIEPFVQPVIHVIETIPIYKLLLKMQKERTHMAILIDEYGG TSGLVTVEDIIEEIVGEIRDEFDADEVPHIRELGKDHYLLNAKLLISDVNSLLGTDLS EAEVDTLGGWFLTQNIDAEPESAIEYDGYSFKVKDINSHHILFIEVKKAE*" /label="yqhB CDS" gene 2146349..2147677 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /label="yqhB gene" S_feature 2147678..2148652 /Source="Nicolas_S_feature" /locus_tag="new_2562914_2563888" /HighExp="Sw, Salt, Etha, LPhT, M9-stat, S8, BC, S6, BT, Gly" /AntisenseName="rsbRD" /AntisenseCor="0.58358076577781004" /AntisenseRegPval="-25.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S927" CDS complement(2147730..2148566) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11157946, 15312768, 15583165, 16963570, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157946, 15312768, 15583165, 16963570, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_390356.2" /db_xref="EnsemblGenomes-Gn:BSU24760" /db_xref="EnsemblGenomes-Tr:CAB14407" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR025751" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11694" /db_xref="UniProtKB/Swiss-Prot:P54504" /translation="MIALDQHLTEHKKDITQQWLEVCTSNGSWLYSAKDQQKLEQKLK DQHELLVTIVAKSLRKEDVEDELNRWSLQCARDRAVHEVTVTQSVGQFNTFRHIMFEW IHKFSEASSQDISIQEFYEWSRILNQNIDEIIEVFTEEYHQVTMIQLNAQKEMINELS APIMPITDGIGILPLVGEIDTHRARTILESVLEQCSALKLSYLFLDISGVPIVDTMVA YQIFKVIDSTKLLGIETIISGIRPEIAQTVVKLGLDFSNVKTEQSLAKALANKGFKIK EC*" /label="rsbRD CDS" gene complement(2147730..2148566) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /label="rsbRD gene" S_feature complement(2148567..2148751) /Source="Nicolas_S_feature" /locus_tag="new_2563803_2563987_c" /HighExp="Etha, LoTm, Salt, Heat, Gly, M9-stat, B60, S8, S0, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147982" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S928" tRNA 2148653..2148723 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln (UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /label="trnSL-Gln1 tRNA" gene 2148653..2148723 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /label="trnSL-Gln1 gene" CDS complement(2148790..2149170) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:18643936, 22812682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18643936, 22812682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of stress" /protein_id="NP_390357.2" /db_xref="EnsemblGenomes-Gn:BSU24770" /db_xref="EnsemblGenomes-Tr:CAB14408" /db_xref="GOA:P54503" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11693" /db_xref="UniProtKB/Swiss-Prot:P54503" /translation="MEQQLTFYSYPSCTSCRKTKHWLKAHQIEFNERHLFRETPTREE LKYILSLTTEGIDEILATRSQTFKNLNLNIEEMTVNEVLELLIEKPKLLRRPILVDNK KLVIGYNPGELLKLSKKKTVHQSA*" /label="mgsR CDS" gene complement(2148790..2149170) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /label="mgsR gene" downshifts complement(2148796) /Source="Nicolas_upshifts" /id="D1284" /incds=0 /nref=9 /ntot=174 /MaxReadThrough="6.12556" /MaxDrop="6.72616" /score="0.164931099" /energy="-19.7" /TU="U1922" /idTUdmin="U1925" /TUdmin=912 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2149199..2149217) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2149218) /Source="Nicolas_upshifts" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2149232..2149238) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2149257..2149262 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-35" promotor_-10 2149278..2149296 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-10" upshifts 2149287 /Source="Nicolas_upshifts" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="upshifts" promotor_-35 2149337..2149344 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-35" upshifts 2149359 /Source="Nicolas_upshifts" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="upshifts" promotor_-10 2149360..2149379 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-10" CDS 2149402..2149647 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390358.1" /db_xref="EnsemblGenomes-Gn:BSU24780" /db_xref="EnsemblGenomes-Tr:CAB14409" /db_xref="GOA:P54502" /db_xref="InterPro:IPR020254" /db_xref="SubtiList:BG11692" /db_xref="UniProtKB/Swiss-Prot:P54502" /translation="MNRMFRVLGFWTGIFAVMFYLGDMKDASLLFFGQTILFVFLSYL NLTERMYIYIFGAYLTIFFAGFTYYSIFIMVPGGGGH*" /label="yqgY CDS" gene 2149402..2149647 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /label="yqgY gene" downshifts 2149544 /Source="Nicolas_upshifts" /id="D1285" /incds=1 /nref=1 /ntot=86 /MaxReadThrough="6.68961" /MaxDrop="2.1025" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=176 /isTUend="FALSE" /label="downshifts" downshifts 2149633 /Source="Nicolas_upshifts" /id="D1286" /incds=0 /nref=98 /ntot=234 /MaxReadThrough="4.03872" /MaxDrop="5.76938" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=265 /isTUend="FALSE" /label="downshifts" S_feature 2149678..2150433 /Source="Nicolas_S_feature" /locus_tag="new_2564914_2565669" /HighExp="M9-stat, T0.30H, T1.30H, LoTm, T1.0H, B60, T2.0H, S5, S4, T2.30H" /AntisenseName="yqgX" /AntisenseCor="-0.68109878166952498" /AntisenseRegPval="-37.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S929" CDS complement(2149687..2150322) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20669241, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-binding hydrolase" /protein_id="NP_390359.1" /db_xref="EnsemblGenomes-Gn:BSU24790" /db_xref="EnsemblGenomes-Tr:CAB14410" /db_xref="GOA:P54501" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11691" /db_xref="UniProtKB/Swiss-Prot:P54501" /translation="MKWRRMPVGPIQANAYFLISDDQCLIFDPGGEGHKINQYIKEKG LTPLAILLTHAHFDHIGALDEVREKWDIPVYLHQNEKNWLADASLNGSGMLRGIEVTA KPADHLIEGDGELNIGPFHLETLFTPGHSPGSVSYYVKDADLVISGDVLFQGGIGRTD LIGGNQETLLTSIHEKLLTLPEHTLVLSGHGPETDVLTEQDQNPFLNGFSL*" /label="yqgX CDS" gene complement(2149687..2150322) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /label="yqgX gene" downshifts complement(2149712) /Source="Nicolas_upshifts" /id="D1287" /incds=0 /nref=154 /ntot=239 /MaxReadThrough="1.42757" /MaxDrop="5.15622" /score="-8.36666809" /energy="-13.7" /TU="NA" /idTUdmin="U1925" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2150344..2150363) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2150361) /Source="Nicolas_upshifts" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2150377..2150384) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2150401..2150408 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2150423..2150442 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2150435 /Source="Nicolas_upshifts" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2150455) /Source="Nicolas_upshifts" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2150457..2150471) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2150479..2150483) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2150479..2150652 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390360.1" /db_xref="EnsemblGenomes-Gn:BSU24800" /db_xref="EnsemblGenomes-Tr:CAB14411" /db_xref="GOA:P54500" /db_xref="InterPro:IPR024490" /db_xref="SubtiList:BG11690" /db_xref="UniProtKB/Swiss-Prot:P54500" /translation="MLLVVIFGLVALFALWGVLRSVRNKNILGFLLAGATLFVFGWFT VMTVINSGYPTAH*" /label="yqgW CDS" gene 2150479..2150652 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /label="yqgW gene" downshifts 2150640 /Source="Nicolas_upshifts" /id="D1288" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="3.92092" /MaxDrop="7.18555" /score="14.1643615" /energy="-12.4" /TU="U1926" /idTUdmin="U1924" /TUdmin=217 /isTUend="FALSE" /label="downshifts" CDS complement(2150684..2150998) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390361.2" /db_xref="EnsemblGenomes-Gn:BSU24810" /db_xref="EnsemblGenomes-Tr:CAB14412" /db_xref="GOA:P54499" /db_xref="InterPro:IPR002767" /db_xref="InterPro:IPR029756" /db_xref="SubtiList:BG11689" /db_xref="UniProtKB/Swiss-Prot:P54499" /translation="MAIADVTIIPIGTETPSVSAYVADVQKILEGYQAEGKIKYQLTP MNTLIEGELSDLFAVIQAIHEAPFQKGLHRVATNIRIDDRRDKKTTLESKIESVNKHL QP*" /label="yqgV CDS" gene complement(2150684..2150998) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /label="yqgV gene" S_feature 2150685..2151752 /Source="Nicolas_S_feature" /locus_tag="new_2565921_2566988" /HighExp="LoTm, M9-stat, C30, Cold, S8, S7, B60, Lbstat, G135, C90" /AntisenseName="yqgV" /AntisenseCor="-0.23995763414552801" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigEF" /TUlongPSig="1, 1" /label="S930" downshifts complement(2150698) /Source="Nicolas_upshifts" /id="D1289" /incds=0 /nref=247 /ntot=265 /MaxReadThrough="2.24429" /MaxDrop="6.85096" /score="0.185625845" /energy="-12.4" /TU="NA" /idTUdmin="U1928" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2151001..2152062) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390362.2" /db_xref="EnsemblGenomes-Gn:BSU24820" /db_xref="EnsemblGenomes-Tr:CAB14413" /db_xref="GOA:P54498" /db_xref="SubtiList:BG11688" /db_xref="UniProtKB/Swiss-Prot:P54498" /translation="MLMRSVCFILLAVLLFSLSACEPSHQQQKQASAAKDEKKDIIPL SAEKADGAEGWLNNSTILYTASNPTKTELFAYRIFTGKAKKLYQTDGQIVDVQINARE QMILLQITHSQKTAVVLLNAEGETLYEKDYETYELEAAWNQYDPYQMMVTEFNENWDF HTYQVNAKKDESFLSPVQVPFIHWTSKNTFDYVKEGRDDKTGPLYTFDTASKTEQKLE DNVLFFDSFHQMSFTVKSASGGKGTYQFKTPQSTSPVTAKWPLQAKYTSLAPMEYDYD EAGGLFYTFKQSGDAYKLAAINVASGETKDLVSLREMEPIQISPNGKYALYGFHFEQI ILLKSHETKQLIIDQKEME*" /label="yqgU CDS" gene complement(2151001..2152062) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /label="yqgU gene" CDS complement(2152124..2153254) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12765833, 24163346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative d,l-endopeptidase" /protein_id="NP_390363.1" /db_xref="EnsemblGenomes-Gn:BSU24830" /db_xref="EnsemblGenomes-Tr:CAB14414" /db_xref="GOA:P54497" /db_xref="InterPro:IPR000834" /db_xref="InterPro:IPR034274" /db_xref="SubtiList:BG11687" /db_xref="UniProtKB/Swiss-Prot:P54497" /translation="MMAFITVKPEIKNNLANVAKELKIDEELLKSANRSAQKHQLYCP GYVIEEHSGKELQTIQDIKRFLQPRQLKLSDSWIEQEKIYDDSAVEKEIKKIIDVFPF VSCREIGRSVLGRPIWELKAGGEHAVKKVHMNASFHANEWITTSVLLKWFKEYCMSLC CNSPFFGFSPIKLFNSTSLSLVPLVNPDGVDLVLNGSEVMGARRDELERLNEHRPNFN EWKANINGVDLNKQFPSLWEIEKYRKPTAPSYRDFPGISPLTEPESIAMYRLITENPP DRLLALHTQGEEIYWGYKGLEPEESAAVIKEFEELSGNIYKGVRDIDSYAGFRDWFIH HYFKEGYTVELGKGQNPLPFQQFSHIYNATSGILWRALFFHE*" /label="yqgT CDS" gene complement(2152124..2153254) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /label="yqgT gene" promotor_-10 complement(2153262..2153280) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2153294) /Source="Nicolas_upshifts" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2153296..2153301) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2153337..2155253) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647, 25666134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647, 25666134; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_390364.2" /db_xref="EnsemblGenomes-Gn:BSU24840" /db_xref="EnsemblGenomes-Tr:CAB14415" /db_xref="GOA:P54496" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG11686" /db_xref="UniProtKB/Swiss-Prot:P54496" /translation="MRKTFFSKISFMLIAILLMWLKTYAVYKTSFHIKIDNLTQEFIL FINPLSFLLLIFGLSLFLKGKNRNRYIIAMSCLVTFVLLANMVFYRFYNDFLTIPVLF QTSNMGDLGSSIGTLLEPTDLLLAVDIAVLIWLHIRQKAFQSDIPSTKNERAAYFLFV ASVYFFNLGLSEAERPQLLTRSFDREMLVKNISLFNFHIYDGVLQSKQSAQRALADSN SLTEIENYVTANAKDANKRLFGAAKGRNVILVSLESTQSFVINEKLNGEEITPFLNDF IKQSYNFNNVYHQTGQGKTSDSEFIVDNSLYPLGRGAVFFTNAGNQYMAAPEILKNSG YYSAVLHANNKSFWNRDLMYDSFGYDSFFDINSYDVTDENSVGWGLKDKEFFEQSSEL MKNLPQPFYSRLITLTNHFPFDLDEEDQLIDEYDSNSQTLNKYFPTVRYQDEALKRFI EKLKEDGLYDNSVIVLYGDHYGISENHNEAMGQFLGKEITPFEEVQLQKVPLVIHIPG ITDKKPQTIETVGGQIDIRPTLMNLLGIDTKDQIQFGNDLLSDEKLDFTVLRDGSFIT DQVVYTDGACYDKETGKPLEETKQCEAFADKAKQELSLSDEIIYGDLLRFYDQKRLDN SSKRKEKQMLDQAS*" /label="ltaSC CDS" gene complement(2153337..2155253) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /label="ltaSC gene" downshifts complement(2153364) /Source="Nicolas_upshifts" /id="D1290" /incds=0 /nref=5 /ntot=142 /MaxReadThrough="4.5611" /MaxDrop="3.8416" /score="15.4764643" /energy="-14.5" /TU="U1930,U1931" /idTUdmin="U1928" /TUdmin="-2667" /isTUend="FALSE" /label="downshifts" promotor_-35 2154369..2154375 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2154388..2155417 /Source="Nicolas_S_feature" /locus_tag="new_2569624_2570653" /HighExp="Etha, Gly, M9-stat, Salt, S8, LPhT, S7, Sw, HiTm, B60" /AntisenseName="yqgS" /AntisenseCor="-0.36996929809172002" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S931" upshifts 2154388 /Source="Nicolas_upshifts" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2154391..2154409 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(2155254..2155320) /Source="Nicolas_S_feature" /locus_tag="new_2570490_2570556_c" /HighExp="T-3.40H, BC, Sw, S5, Lbstat, T-5.40H, S4, ferm, C30, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S932" promotor_-10 complement(2155314..2155333) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2155320) /Source="Nicolas_upshifts" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2155348..2155355) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2155370..2156335) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /EC_number="2.7.1.59" /EC_number="2.7.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose kinase" /protein_id="NP_390365.2" /db_xref="EnsemblGenomes-Gn:BSU24850" /db_xref="EnsemblGenomes-Tr:CAB14416" /db_xref="GOA:P54495" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR004654" /db_xref="SubtiList:BG11685" /db_xref="UniProtKB/Swiss-Prot:P54495" /translation="MDEIWFAGIDLGGTTIKLAFINQYGEIQHKWEVPTDKTGDTITV TIAKTIDSKLDELQKPKHIIKYIGMGAPGPVDMAAGVVYETVNLGWKNYALKNHLETE TGIPAVIENDANIAALGEMWKGAGDGAKDVILVTLGTGVGGGIIANGEIVHGINGAGG EIGHICSIPEGGAPCNCGKTGCIETIASATGIVRIAKEKIANAKKTTRLKATEQLSAR DVFEAAGENDEIALEVVDYVAKHLGLVLGNLASSLNPSKIVLGGGVSRAGELLRSKVE KTFRKCAFPRAAQAADISIAALGNDAGVIGGAWIAKNEWLKHQNC*" /label="glcK CDS" gene complement(2155370..2156335) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /label="glcK gene" CDS complement(2156346..2156561) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /function="9.3: Transcription factors" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15050034, 20057058; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative single strand nucleic acid binding transcription factor" /protein_id="NP_390366.1" /db_xref="EnsemblGenomes-Gn:BSU24860" /db_xref="EnsemblGenomes-Tr:CAB14417" /db_xref="InterPro:IPR009256" /db_xref="InterPro:IPR023164" /db_xref="PDB:2NN4" /db_xref="SubtiList:BG11684" /db_xref="UniProtKB/Swiss-Prot:P54494" /translation="MNTFYDVQQLLKTFGHIVYFGDRELEIEFMLDELKELYMNHMIE KEQWARAAAVLRKELEQTKNGRDFYKG*" /label="yqgQ CDS" gene complement(2156346..2156561) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /label="yqgQ gene" S_feature complement(2156562..2156670) /Source="Nicolas_S_feature" /locus_tag="new_2571798_2571906_c" /HighExp="M0t90, Lbstat, M40t90, M40t45, Lbtran, Mt0, dia5, Diami, M0t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S933" CDS complement(2156671..2158194) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /EC_number="3.4.21.105" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15050034, 16355228, 23518036, 26858402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane endopeptidase" /protein_id="NP_390367.2" /db_xref="EnsemblGenomes-Gn:BSU24870" /db_xref="EnsemblGenomes-Tr:CAB14418" /db_xref="GOA:P54493" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG11683" /db_xref="UniProtKB/Swiss-Prot:P54493" /translation="MFLLEYTYWKIAAHLVNSGYGVIQAGESDEIWLEAPDKSSHDLV RLYKHDLDFRQEMVRDIEEQAERVERVRHQLGRRRMKLLNVFFSTEAPVDDWEEIAKK TFEKGTVSVEPAIVRGTMLRDDLQAVFPSFRTEDCSEEHASFENAQMARERFLSLVLK QEEQRKTEAAVFQNGKPTFTYLFIALQILMFFLLEINGGSTNTETLVAFGAKENSLIA QGEWWRLLTPIVLHIGIAHLAFNTLALWSVGTAVERMYGSGRFLLIYLAAGITGSIAS FVFSPYPSAGASGAIFGCLGALLYVALSNRKMFLRTIGTNIIVIIIINLGFGFAVSNI DNSGHIGGLIGGFFAAAALGLPKAGAFGKRLLSAVLLIALAVGFLYYGLHSPSHQESA LIQQASELYQEGKYEEVTELLNGEAAQKDASADLLKILAVSDIQIGEYDQAVSLLERA VKKEPKDHASYYNLALLYAEKNELAQAEKAIQTAVKLKPKEQRYKELQRQIENNKES* " /label="glpG CDS" gene complement(2156671..2158194) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /label="glpG gene" promotor_-10 complement(2158212..2158231) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2158225) /Source="Nicolas_upshifts" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2158246..2158253) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2158284..2158457) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390368.1" /db_xref="EnsemblGenomes-Gn:BSU24880" /db_xref="EnsemblGenomes-Tr:CAB14419" /db_xref="SubtiList:BG11682" /db_xref="UniProtKB/Swiss-Prot:P54492" /translation="MKKLLIYAIFAVSAVMFYQNRYRLMNTVLSQPGIRRSFIHLFLR IPFIRNKFIQQAF*" /label="yqgO CDS" gene complement(2158284..2158457) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /label="yqgO gene" downshifts complement(2158311) /Source="Nicolas_upshifts" /id="D1291" /incds=0 /nref=121 /ntot=211 /MaxReadThrough="2.93694" /MaxDrop="5.6047" /score="19.2452946" /energy="-8.9" /TU="NA" /idTUdmin="U1932" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2158473..2158484) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2158485) /Source="Nicolas_upshifts" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2158498..2158504) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2158524..2159087) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /EC_number="6.3.3.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17329806, 20952389, 22773193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-formyltetrahydrofolate cyclo-ligase" /protein_id="NP_390369.1" /db_xref="EnsemblGenomes-Gn:BSU24890" /db_xref="EnsemblGenomes-Tr:CAB14420" /db_xref="GOA:P54491" /db_xref="InterPro:IPR002698" /db_xref="PDB:1YDM" /db_xref="SubtiList:BG11681" /db_xref="UniProtKB/Swiss-Prot:P54491" /translation="MKSQLRKKTLEALSALSNEDILQKTERMYKYLFSLPEWQNAGTI AVTISRGLEIPTRPVIEQAWEEGKQVCIPKCHPDTKKMQFRTYQTDDQLETVYAGLLE PVIEKTKEVNPSQIDLMIVPGVCFDVNGFRVGFGGGYYDRYLSEYEGKTVSLLLECQL FAHVPRLPHDIPVHKLITEDRIISCFS*" /label="folN CDS" gene complement(2158524..2159087) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /label="folN gene" S_feature complement(2159088..2159171) /Source="Nicolas_S_feature" /locus_tag="new_2574324_2574407_c" /HighExp="Cold, G180, LBGexp, LBGtran, G135, HPh, LPh, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S934" CDS complement(2159172..2159321) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12904577, 19648245, 22720735, 23002217, 27561249; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_570908.2" /db_xref="EnsemblGenomes-Gn:BSU24900" /db_xref="EnsemblGenomes-Tr:CAE01461" /db_xref="GOA:P56849" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG14180" /db_xref="UniProtKB/Swiss-Prot:P56849" /translation="MRVNITLACTECGERNYISKKNKRNNPDRVEFKKYCPRDKKSTL HRETK*" /label="rpmGA CDS" gene complement(2159172..2159321) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /label="rpmGA gene" downshifts complement(2159218) /Source="Nicolas_upshifts" /id="D1292" /incds=0 /nref=154 /ntot=253 /MaxReadThrough="5.3064" /MaxDrop="4.5881" /score="34.7393253" /energy="-15.3" /TU="U1933" /idTUdmin="U1932" /TUdmin="-907" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2159358..2159377) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2159368) /Source="Nicolas_upshifts" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2159393..2159396) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2159405..2160484) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_390370.2" /db_xref="EnsemblGenomes-Gn:BSU24910" /db_xref="EnsemblGenomes-Tr:CAB14421" /db_xref="GOA:P54490" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11680" /db_xref="UniProtKB/Swiss-Prot:P54490" /translation="MNILMLSPEHPDEPKSGLGVHLNRLISYLNPHINITVFTPSGQL FSYAKFEDYIADANFTMVRHVLSHNKRFDLIHAHDDTTAPAAQYLKQRLGLPLAATIH GLESERKKVCREAPHPYRLMTERLLIESADALIVLSTFMKRSLDKAAHKKITVIPSPA SMEEEKGKIPRSMNRRFLFSYGRFVPEKGLSQLLKVFAILKQRQPDLYLVLAGEGPSL SCYEKLAAAYNLKDRVMFLPFLNRKDIRTLLSHCEMAVFPSSYEPFGLAAQESMEQGV LTVVSQSGGFCDYAVHDKTAIIADFTLVQEAADLLDSFLKDREKARRIKEAGRQQVFK LHHPRLIMSSYLQLYERIFNNSAIH*" /label="yqgM CDS" gene complement(2159405..2160484) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /label="yqgM gene" CDS complement(2160481..2160951) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390371.1" /db_xref="EnsemblGenomes-Gn:BSU24920" /db_xref="EnsemblGenomes-Tr:CAB14422" /db_xref="SubtiList:BG11679" /db_xref="UniProtKB/Swiss-Prot:P54489" /translation="MDKHPFPYNIRHKLSFFRDTFDIIIQNAHTLTVSWEISEETMRL AEAVLFEKTQDMIKELRIVIKRKDIEAVRTKRTTYDKGEWTIRQAAGDAVYRAEYRIV NSMNVSLKLAGTDDIYLDENGIRHINSFQIEEAHTRWEAQFSAYTCYGRGEKER*" /label="yqgL CDS" gene complement(2160481..2160951) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /label="yqgL gene" promotor_-35 2160896..2160904 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2160918..2160926 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2160919..2161092 /Source="Nicolas_S_feature" /locus_tag="new_2576155_2576328" /HighExp="M9-stat, T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, Lbstat, T3.30H, B60" /AntisenseName="yqgL" /AntisenseCor="0.210779859401483" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S935" upshifts 2160920 /Source="Nicolas_upshifts" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2160987..2161006) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2160999) /Source="Nicolas_upshifts" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2161018..2161025) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2161064..2161068 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2161084..2161103 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2161094 /Source="Nicolas_upshifts" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="upshifts" CDS 2161131..2161484 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390372.1" /db_xref="EnsemblGenomes-Gn:BSU24930" /db_xref="EnsemblGenomes-Tr:CAB14423" /db_xref="GOA:O32022" /db_xref="SubtiList:BG13770" /db_xref="UniProtKB/Swiss-Prot:O32022" /translation="MEIAIIALFIVSIALIAFSYSQRDPMKDVEQELETLQLSAMQEI YKLKKKMTVLEEELLETNLVIRKSKQNDINQKIAKQILSKYNNGMSAEAIAKAEHVSV EDVNTIIKDNEKVLV*" /label="yqzD CDS" gene 2161131..2161484 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /label="yqzD gene" CDS 2161481..2161945 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390373.2" /db_xref="EnsemblGenomes-Gn:BSU24940" /db_xref="EnsemblGenomes-Tr:CAB14424" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13769" /db_xref="UniProtKB/Swiss-Prot:O32023" /translation="MTKRGIQAFAGGIILATAVLAAVFYLTDEDQAAAVKDNKTVTEQ DVNNYLDSKKLVSVNRDEYQKLLDSKEKSLNNDSGSDTKSDKVKTYKLTIKDGMSTAD VSAILEKEGIISSAQDFNDYVIDAGYHKEIRAGEFKVKSDMSFKKIVKTLTR*" /label="yqzC CDS" gene 2161481..2161945 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /label="yqzC gene" downshifts 2161931 /Source="Nicolas_upshifts" /id="D1293" /incds=0 /nref=216 /ntot=264 /MaxReadThrough="0.9847" /MaxDrop="6.07831" /score="21.2108939" /energy="-8.8" /TU="NA" /idTUdmin="U1934" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2161974..2162756) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390374.1" /db_xref="EnsemblGenomes-Gn:BSU24950" /db_xref="EnsemblGenomes-Tr:CAB14425" /db_xref="GOA:P46342" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11379" /db_xref="UniProtKB/Swiss-Prot:P46342" /translation="MSIATEAVMKQEVYQVNGMNLWYGQHHALKNINLSIYENEVTAI IGPSGCGKSTFIKTLNLMIQMTPNVKLAGELNYNGSNILKDKVDIVDLRKNIGMVFQK GNPFPQSIFDNVAYGPRVHGTKNKKKLQEIVEKSLKDVALWDEVKDRLHTSALSLSGG QQQRLCIARALATNPDILLMDEPTSALDPISTRKIEELILELKDKYTIVIVTHNMQQA ARVSDQTAFFYMGELVECDNTNKMFSNPKDQRTLDYISGKFG*" /label="pstBB CDS" gene complement(2161974..2162756) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /label="pstBB gene" downshifts complement(2161985) /Source="Nicolas_upshifts" /id="D1294" /incds=0 /nref=20 /ntot=46 /MaxReadThrough="2.29658" /MaxDrop="6.53816" /score="26.1659198" /energy="-8.8" /TU="NA" /idTUdmin="U1937" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2162767..2163576) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390375.1" /db_xref="EnsemblGenomes-Gn:BSU24960" /db_xref="EnsemblGenomes-Tr:CAB14426" /db_xref="GOA:P46341" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11378" /db_xref="UniProtKB/Swiss-Prot:P46341" /translation="MSEQMVKEKPERAVIVPKQNHVLEVKDLSIYYGNKQAVHHVNMD IEKNAVTALIGPSGCGKSTFLRNINRMNDLIPSARAEGEILYEGLNILGGNINVVSLR REIGMVFQKPNPFPKSIYANITHALKYAGERNKAVLDEIVEESLTKAALWDEVKDRLH SSALSLSGGQQQRLCIARTLAMKPAVLLLDEPASALDPISNAKIEELITGLKREYSII IVTHNMQQALRVSDRTAFFLNGELVEYGQTEQIFTSPKKQKTEDYINGKFG*" /label="pstBA CDS" gene complement(2162767..2163576) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /label="pstBA gene" CDS complement(2163597..2164481) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390376.2" /db_xref="EnsemblGenomes-Gn:BSU24970" /db_xref="EnsemblGenomes-Tr:CAB14427" /db_xref="GOA:P46340" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR005672" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11377" /db_xref="UniProtKB/Swiss-Prot:P46340" /translation="MNRKITDKLATGMFGLCAAIIAAILVGLFSYIIINGVSQLSFQF ITTKSSAIAAGGGIRDQLFNSFYILFITMLITIPLGVGGGVFMAEYAPNNKVTDFIRT CIEVLSSLPSIVIGMFGLLMFVNLTGWGYTIIGGALALTVFNLPVMVRVTEDAIRSVP KDLKEASLALGVSRWHTVKTVLIPSAIPSIITGAILASGRVFGEAAALLFTAGLTTPR LNFTEWNPFSETSPLNIFRPAETLAVHIWNVNTQGMIPDAEAIANGGSAVLVISVLVF NLAARWLGTMIYKKLTAN*" /label="pstA CDS" gene complement(2163597..2164481) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /label="pstA gene" CDS complement(2164481..2165410) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390377.2" /db_xref="EnsemblGenomes-Gn:BSU24980" /db_xref="EnsemblGenomes-Tr:CAB14428" /db_xref="GOA:P46339" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011864" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11376" /db_xref="UniProtKB/Swiss-Prot:P46339" /translation="MINNRENMSVSERLISSRQNRQLDEVRGRMIVTACALIMIAASV AITIFLGVKGLQSFLVNGVSPIEFLTSLNWNPTDSDPKYGVLPFIFGSFAVTILSALI AAPLGIAGAIFMTEIAPNWGKKVLQPVIELLVGIPSVVYGFIGLTVLVPFIAQFKSSG TGHSLLAGTIVLSVMILPTITSISADAMASLPKSLREGSYALGATRWQTIRKVLVPAA FPTLMTAVVLGMARAFGEALAVQMVIGNTRVLPESPFDTAGTLTTIITLNMGHTTYGS VENNTLWSMGLVLLVMSFLFILLIRYLSSRRKV*" /label="pstC CDS" gene complement(2164481..2165410) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /label="pstC gene" CDS complement(2165479..2166381) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 9593301, 10913081, 15289558, 21461370, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 9593301, 10913081, 15289558, 21461370, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (phosphate binding lipoprotein)" /protein_id="NP_390378.1" /db_xref="EnsemblGenomes-Gn:BSU24990" /db_xref="EnsemblGenomes-Tr:CAB14429" /db_xref="GOA:P46338" /db_xref="InterPro:IPR011862" /db_xref="InterPro:IPR024370" /db_xref="SubtiList:BG11375" /db_xref="UniProtKB/Swiss-Prot:P46338" /translation="MKKNKLVLMLLMAAFMMIAAACGNAGESKKSNSDSAKGEEKASG SLTISGSSAMQPLVLAAAEKFMEENPDADIQVQAGGSGTGLSQVSEGAVQIGNSDVFA EEKEGIDAKALVDHQVAVVGMAAAVNPDAGVKDISKDELKKIFTGKIKNWKELGGKDQ KITLVNRPDSSGTRATFVKYALDGAEPAEGITEDSSNTVKKIIADTPGAIGYLAFSYL TDDKVTALSIDGVKPEAKNVATGEYPIWAYQHSYTKGEATGLAKEFLDYLKSEDIQKS IVTDQGYIPVTDMKVTRDANGKQS*" /label="pstS CDS" gene complement(2165479..2166381) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /label="pstS gene" upshifts complement(2166436) /Source="Nicolas_upshifts" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2166444..2166460) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2166471..2166473) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-35" Polymorphism join(2166490,2166492) /Source="geneious" /ID="SNP_BsDelta6_2581727_2581726" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(T)6 -> (T)7" /Codon_Change /Coverage=117 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=114 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(2166536..2168686) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /EC_number="3.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9139922, 9851991, 12896990, 17307860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139922, 9851991, 12896990, 17307860; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transpeptidase (penicillin-binding protein 2A)" /protein_id="NP_390379.1" /db_xref="EnsemblGenomes-Gn:BSU25000" /db_xref="EnsemblGenomes-Tr:CAB14430" /db_xref="GOA:P54488" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11678" /db_xref="UniProtKB/Swiss-Prot:P54488" /translation="MRRNKPKKQNHKEKKKSLPIRLNILFLAAFVIFTWIIVELGIKQ IVQGDDYKNQANKQEQSEVSSAVPRGKIYDRNFNAIVTNKALNAITYTRSKSTTQEQR LKIAKKLSDMIKVDTKKVTERDKKDYWILTRPKEAKKLISSKERQQVEDKKISDDDLY QLQLKRITDKQLNELTDKDMQILAIKRQMDSGYALTPQYIKNEDVSAKEMAVVSEHLD ELPGVDVTSDWEREYPYKNLLRSVLGSVSSSNEGLPSNLLDHYLSLGYSRNDRVGKSY LEYQYESLLQGQKAKVENITDSKGNVTGTKTVSEGKAGKDLVLTIDIDLQKSVEKIIE KKLKAAKARPSTELLDRAFVVMMDPRNGEVLTMAGKQIKRENGAYKFDDYALGAMTSS YAMGSAVKGATVLTGLQTGAINLNTVFKDEPLYIGQDKRGKKSWQNLGPVGIQTALEK SSNVFMFKTAIAVGKGEYKPHQALPLDTSAFDTFRNYFSQFGLGVKTGIDLPNEMTGY KGTSRLSGFLLDFAIGQYDTYTPLELAQYVSTIANGGYRMKPQLVKEVRDSNAKKGIG AVVDSVQPEVLNKVDMKSSYIEEVQAGFRRVATKGTAAGQLASASYKPAAKTGTAQSF YDGPDKSKTGTDTYNTTLVAYAPADNPEIAISVVVPWTYIDYNQRYSITNEIGREVMD KYFELKSKQDKEGTQQKNKDKIEENAENTTSSDN*" /label="pbpA CDS" gene complement(2166536..2168686) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /label="pbpA gene" downshifts complement(2166546) /Source="Nicolas_upshifts" /id="D1295" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="1.22121" /MaxDrop="8.82988" /score="31.2726004" /energy="-10" /TU="U1940" /idTUdmin="U1938" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2167280..2167298) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2167288) /Source="Nicolas_upshifts" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2167314..2167320) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2167975..2167994) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2167992) /Source="Nicolas_upshifts" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2168008..2168017) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2168736..2168755) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2168741) /Source="Nicolas_upshifts" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2168771..2168775) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2168800..2170092) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390380.2" /db_xref="EnsemblGenomes-Gn:BSU25010" /db_xref="EnsemblGenomes-Tr:CAB14431" /db_xref="GOA:P54487" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11677" /db_xref="UniProtKB/Swiss-Prot:P54487" /translation="MSKLKKVIGDVDVNKGLLFLLTIGGLYSLGIALSNTFVNVYLWK QSGKFIDLAIYNLSIVTMQPITFYLAGRLAKKIDRVFILRFGVIFLAAFYLSVLLAGE TAASRLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNGFMGILSSSAGMIGPIV AGFVISRLENNTGYTVIFSLSLSLFALAVVMSFFLKRRESKGRFMLSKVFGERHSNMN WRRITNAHFFQGLREGIFVFLISVFVFIETNSELALGTFGLVNSAVSFFAYYFASRLI KKKARKKSILLGGLILYGALFLILFHMSFSTLLTYGVFIAIGYPLLLVPYVSLTYDVI GRARHARKARIEYIVLREMFLNAGRIVSILCFLLIVALLKEDVGIPLSLAILGIGHPL IYYFVKDIRFKEKEGENETMEEDGQKRVTEPTLLKGER*" /label="yqgE CDS" gene complement(2168800..2170092) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /label="yqgE gene" promotor_-10 complement(2170115..2170126) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2170126) /Source="Nicolas_upshifts" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2170140..2170146) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2170199..2170807) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /EC_number="1.15.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Mn[2+]-dependent)" /protein_id="NP_390381.3" /db_xref="EnsemblGenomes-Gn:BSU25020" /db_xref="EnsemblGenomes-Tr:CAB14432" /db_xref="GOA:P54375" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="PDB:2RCV" /db_xref="SubtiList:BG11676" /db_xref="UniProtKB/Swiss-Prot:P54375" /translation="MAYELPELPYAYDALEPHIDKETMTIHHTKHHNTYVTNLNKAVE GNTALANKSVEELVADLDSVPENIRTAVRNNGGGHANHKLFWTLLSPNGGGEPTGALA EEINSVFGSFDKFKEQFAAAAAGRFGSGWAWLVVNNGKLEITSTPNQDSPLSEGKTPI LGLDVWEHAYYLNYQNRRPDYISAFWNVVNWDEVARLYSEAK*" /label="sodA CDS" gene complement(2170199..2170807) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /label="sodA gene" downshifts complement(2170214) /Source="Nicolas_upshifts" /id="D1296" /incds=0 /nref=265 /ntot=268 /MaxReadThrough="4.329" /MaxDrop="9.16338" /score="3.26408916" /energy="-8.1" /TU="U1943" /idTUdmin="U1942" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2170859..2170878) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2170870) /Source="Nicolas_upshifts" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2170872..2170940) /Source="Nicolas_S_feature" /locus_tag="new_2586107_2586175_c" /HighExp="Etha, Salt, Heat, LPhT, Gly, Sw, S4, LoTm, M9-stat, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigB" /TUlongPSig="0.999" /label="S936" promotor_-35 complement(2170893..2170900) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2170931..2170949) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2170940) /Source="Nicolas_upshifts" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2170964..2170970) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2170986..2171468) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390382.1" /db_xref="EnsemblGenomes-Gn:BSU25030" /db_xref="EnsemblGenomes-Tr:CAB14433" /db_xref="GOA:P54486" /db_xref="InterPro:IPR007403" /db_xref="SubtiList:BG11675" /db_xref="UniProtKB/Swiss-Prot:P54486" /translation="MDMLYWLLIAAVFIIAFIGLVYPVIPSVVFIVAGFVLYGFLFSF SPYSYMFWLVEAVFAAVLFAADYVSNLLGVKRFGGSKAAIWGSTIGLLIGPFVIPVAG IILGPFIGAVCAELIVHQKDLKSAFKIGLGSLIGFLTGVIAKGIIQLLMIGYFLWTVL *" /label="yqgC CDS" gene complement(2170986..2171468) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /label="yqgC gene" S_feature complement(2171469..2171761) /Source="Nicolas_S_feature" /locus_tag="new_2586704_2586996_c" /HighExp="Etha, Gly, Salt, aero, S0, LoTm, HiTm, LPh, nit, ferm" /AntisenseName="yqgB" /AntisenseCor="9.8584854910492598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S937" promotor_-35 2171511..2171517 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2171532..2171551 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2171545 /Source="Nicolas_upshifts" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="upshifts" CDS 2171578..2172345 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15294815; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390383.2" /db_xref="EnsemblGenomes-Gn:BSU25040" /db_xref="EnsemblGenomes-Tr:CAB14434" /db_xref="GOA:P54485" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG11674" /db_xref="UniProtKB/Swiss-Prot:P54485" /translation="MNVFQLFIKSTYSPRDIAKTRFQGIGKAILYVFLLSVLFAIPTA YYVSTGTVKSMNGFKTVLNKDFPDFTISNGKLQTDEKKATESQANGFVIVFDPTDSYG TEQIEAKQNAIGILQNKFVLAIDGQAQEMSYSMMPSELQKKDVIAGLNQNKAMIVTVL SALIFLVTAAGKFIEVSFLALIGLIIKNSQKKHLSYHQLWKLSAYSITLSTVFFTIMR ALEATVPSEFLLNWFVNFVILFLVLKEIPSKKVINKS*" /label="yqgB CDS" gene 2171578..2172345 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /label="yqgB gene" promotor_-10 complement(2171759..2171777) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-10" upshifts complement(2171761) /Source="Nicolas_upshifts" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="upshifts" S_feature complement(2171763..2172699) /Source="Nicolas_S_feature" /locus_tag="new_2586998_2587934_c" /HighExp="S0, S1, aero, M0t45, HPh, Lbtran, LPh, GM 120, nit, M/G" /AntisenseName="yqgB" /AntisenseCor="0.31978785018705103" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S938" promotor_-35 complement(2171791..2171797) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-35" S_feature 2172346..2172776 /Source="Nicolas_S_feature" /locus_tag="new_2587581_2588011" /HighExp="C30, HiOs, UNK1, Gly, Fru, S8, Salt, MG 5, S7, MG 25" /AntisenseName="yqgA" /AntisenseCor="0.170248276038857" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.731" /TUlongSig="NA" /TUlongPSig="NA" /label="S939" downshifts 2172733 /Source="Nicolas_upshifts" /id="D1297" /incds=0 /nref=5 /ntot=131 /MaxReadThrough="3.89102" /MaxDrop="3.29021" /score="30.8580926" /energy="-13.8" /TU="U1944" /idTUdmin="U1944" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts complement(2172744) /Source="Nicolas_upshifts" /id="D1298" /incds=0 /nref=15 /ntot=207 /MaxReadThrough="6.7306" /MaxDrop="3.9194" /score="7.48192829" /energy="-14.3" /TU="U1947" /idTUdmin="U1945" /TUdmin="-1848" /isTUend="FALSE" /label="downshifts" CDS complement(2172761..2173189) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /experiment="publication(s) with functional evidences, PMID:25130749, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25130749, 27797724; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="cell wall protein" /protein_id="NP_390384.2" /db_xref="EnsemblGenomes-Gn:BSU25050" /db_xref="EnsemblGenomes-Tr:CAB14435" /db_xref="GOA:P54484" /db_xref="SubtiList:BG11673" /db_xref="UniProtKB/Swiss-Prot:P54484" /translation="MKQGKFSVFLILLLMLTLVVAPKEKAEAASSGWQPVSGISGCKI RVITDAYTYTKSATSIDAYAETNGKCGKLNYKSFGVSIVEGGDIGPQYSGYFSSRTPT KKFYFSKLPKPTGTPWAVGLSVYKGKAKGAAFVYINPQKR*" /label="yqgA CDS" gene complement(2172761..2173189) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /label="yqgA gene" promotor_-35 2173185..2173189 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-35" promotor_-10 2173199..2173213 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-10" upshifts 2173208 /Source="Nicolas_upshifts" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="upshifts" promotor_-10 complement(2173212..2173231) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-10" upshifts complement(2173235) /Source="Nicolas_upshifts" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="upshifts" promotor_-35 complement(2173246..2173253) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-35" promotor_-35 2173404..2173409 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2173425..2173443 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2173437 /Source="Nicolas_upshifts" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="upshifts" CDS 2173466..2173765 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15294815; Product type ph : phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390385.1" /db_xref="EnsemblGenomes-Gn:BSU25060" /db_xref="EnsemblGenomes-Tr:CAB14436" /db_xref="GOA:P54483" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR020506" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11672" /db_xref="UniProtKB/Swiss-Prot:P54483" /translation="MKRLTLVCSIVFILFILFYDLKIGTIPIQDLPVYEASAKTAVQE PAYKTVKVKPGDTVMSIVGSAGSPDDIVKDFEALNPNVKANAIQAGTAYKFPVYP*" /label="yqfZ CDS" gene 2173466..2173765 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /label="yqfZ gene" promotor_-35 2173778..2173785 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2173800..2173819 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2173811..2173887 /Source="Nicolas_S_feature" /locus_tag="new_2589046_2589122" /HighExp="Diami, dia5, dia15, H2O2, Etha, Salt, LBGexp, Oxctl, Paraq, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.999, 1" /TUlongSig="Sig-" /TUlongPSig=0 /label="S940" upshifts 2173811 /Source="Nicolas_upshifts" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="upshifts" CDS 2173888..2175021 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /EC_number="1.17.7.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12571359, 16268586, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase)" /protein_id="NP_390386.1" /db_xref="EnsemblGenomes-Gn:BSU25070" /db_xref="EnsemblGenomes-Tr:CAB14437" /db_xref="GOA:P54482" /db_xref="InterPro:IPR004588" /db_xref="InterPro:IPR011005" /db_xref="InterPro:IPR016425" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11671" /db_xref="UniProtKB/Swiss-Prot:P54482" /translation="MQVSEITHRTKTRPVKVGPLTIGGNNEVVIQSMTTTKTHDVEAT VAEINRLAEAGCQIVRVACPDERAANAIADIKKRISIPLVVDIHFDYKLALKAIEGGA DKIRINPGNIGRREKVEAVVKAAKDKGIPIRIGVNAGSLEKRILEKYGYPTADGMVES ALHHIKILEDLDFHDIIVSMKASDVNLAIEAYEKAAKAFDYPLHLGITESGTLFAGTV KSAAGLGAILSKGIGNTMRISLSADPVEEVKVARELLKSFGLASNAATLISCPTCGRI EIDLISIANEVEEYISKIKAPIKVAVLGCAVNGPGEAREADIGIAGARGEGLLFRKGK IVRKVPEETMVEELKKEIDILAEEHYAKLEAEKAKLKEETQKA*" /label="ispG CDS" gene 2173888..2175021 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /label="ispG gene" downshifts 2175002 /Source="Nicolas_upshifts" /id="D1299" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.62035" /MaxDrop="8.92434" /score="30.8580926" /energy="-13.8" /TU="NA" /idTUdmin="U1948" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(2175047..2175436) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function expressed in germinating spores" /protein_id="NP_390387.1" /db_xref="EnsemblGenomes-Gn:BSU25080" /db_xref="EnsemblGenomes-Tr:CAB14438" /db_xref="GOA:P54481" /db_xref="SubtiList:BG11670" /db_xref="UniProtKB/Swiss-Prot:P54481" /translation="MKVANDYEKRDNNSYYVDHGSEGTNITRDNDGFFEETAAEIAEP YRAADRSNDQDNDRSGGNVNEGRGIGYIALALSIISLFVLPVLLGAAGIIVGYIARRR GAQGLGAWAMGIGVVSLVLGIFIIPFF*" /label="yqfX CDS" gene complement(2175047..2175436) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /label="yqfX gene" downshifts complement(2175073) /Source="Nicolas_upshifts" /id="D1300" /incds=0 /nref=10 /ntot=62 /MaxReadThrough="1.85077" /MaxDrop="8.74353" /score="28.1764525" /energy="-13.8" /TU="NA" /idTUdmin="U1950" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2175467..2175478) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2175471) /Source="Nicolas_upshifts" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2175492..2175498) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2175511..2175518 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2175529..2175548 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2175530 /Source="Nicolas_upshifts" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="upshifts" CDS 2175569..2176150 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotidase" /protein_id="NP_390388.1" /db_xref="EnsemblGenomes-Gn:BSU25090" /db_xref="EnsemblGenomes-Tr:CAB14439" /db_xref="GOA:P54480" /db_xref="InterPro:IPR009206" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11669" /db_xref="UniProtKB/Swiss-Prot:P54480" /translation="MLRLGIDIDGTITAQDTFVPYLNRSFNLSISLNDMTDYDLTKLL NITQEEFWDWMNQNEAIIYKEALLAQHAKQSLDLLKEEHKLIYITARRTHLTDITYEW FDRQNIHYDHIELVGGHHKVEAVKNHNIDLFFEDHHGNAMMIAKEAGIPVILFNSPYN QLPIDSNIIRVNNWLEAVQWMNNNKHHLIRVNN*" /label="yqfW CDS" gene 2175569..2176150 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /label="yqfW gene" downshifts 2176148 /Source="Nicolas_upshifts" /id="D1301" /incds=0 /nref=34 /ntot=240 /MaxReadThrough="4.07255" /MaxDrop="4.44714" /score="-2.90660182" /energy="-8" /TU="U1951" /idTUdmin="U1951" /TUdmin="-611" /isTUend="FALSE" /label="downshifts" S_feature 2176193..2176801 /Source="Nicolas_S_feature" /locus_tag="new_2591428_2592036" /HighExp="LoTm, S8, Cold, S7, S5, Sw, BC, S6, HiOs, B60" /AntisenseName="zur" /AntisenseCor="-0.265512398914523" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S941" CDS complement(2176193..2176630) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Zn[2+]-binding Fur family)" /protein_id="NP_390389.2" /db_xref="EnsemblGenomes-Gn:BSU25100" /db_xref="EnsemblGenomes-Tr:CAB14440" /db_xref="GOA:P54479" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11668" /db_xref="UniProtKB/Swiss-Prot:P54479" /translation="MNVQEALNLLKENGYKYTNKREDMLQLFADSDRYLTAKNVLSAL NDDYPGLSFDTIYRNLSLYEELGILETTELSGEKLFRFKCSFTHHHHHFICLACGKTK EIESCPMDKLCDDLDGYQVSGHKFEIYGTCPDCTAENQENTTA*" /label="zur CDS" gene complement(2176193..2176630) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /label="zur gene" downshifts complement(2176197) /Source="Nicolas_upshifts" /id="D1302" /incds=0 /nref=181 /ntot=243 /MaxReadThrough="2.37371" /MaxDrop="6.74703" /score="16.4418277" /energy="-11.9" /TU="U1956" /idTUdmin="U1952" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2176631..2176725) /Source="Nicolas_S_feature" /locus_tag="new_2591866_2591960_c" /HighExp="LPhT, G180, Cold, LBGstat, H2O2, Oxctl, G135, G150, HPh, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S942" promotor_-10 complement(2176721..2176740) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2176725) /Source="Nicolas_upshifts" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2176755..2176762) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2176768..2177649) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390390.2" /db_xref="EnsemblGenomes-Gn:BSU25110" /db_xref="EnsemblGenomes-Tr:CAB14441" /db_xref="GOA:P54478" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11667" /db_xref="UniProtKB/Swiss-Prot:P54478" /translation="MTPTKQHKKETFTHFIFRVFMILVGAASAAVSIELFLIPNDFID GGIIGVSLILDHLFMSNPFLNFAFFVVILNIPFMIFGYKYIGKTFLVSTFIGIVGLAV IESSLHHVEAITTQPILATVFGGLLLGFGVGLVIRNGGSMDGTEILGILLTKKLPFSV GEFVMFINVFIFIWAVFVFGPEQAMYSFMTYYIAMKTIDAVIQGLDETKAVIIVSEQY DEISDAILHRLGRGTTKLKGKGGYTDEEKDVIYAVVTRLEVTKLKSIVFEVDQNAFIT IMNTHETRGGKFKNAIH*" /label="yqfU CDS" gene complement(2176768..2177649) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /label="yqfU gene" promotor_-35 2177645..2177650 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2177666..2177684 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2177682 /Source="Nicolas_upshifts" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2177687..2177706) /Source="Nicolas_upshift_promotors" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2177693) /Source="Nicolas_upshifts" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2177695..2178022) /Source="Nicolas_S_feature" /locus_tag="new_2592930_2593257_c" /HighExp="Cold, T-4.40H, T-5.40H, Salt, GM-0.1, BMM, UNK1, MG 25, GM-0.2, SMM" /AntisenseName="yqfT" /AntisenseCor="-0.62379514374156597" /AntisenseRegPval="-29.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S943" promotor_-35 2177711..2177720 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2177727 /Source="Nicolas_upshifts" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2177733..2177752 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2177765..2178019 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390391.1" /db_xref="EnsemblGenomes-Gn:BSU25120" /db_xref="EnsemblGenomes-Tr:CAB14442" /db_xref="InterPro:IPR020277" /db_xref="SubtiList:BG11666" /db_xref="UniProtKB/Swiss-Prot:P54477" /translation="MILFQRIILQRLNQATADDLLKYSKQYGISLTRSQAVEVANLLY GKNVNIFNESERMRLLKQVETITSKETAQTVNELFKQFTS*" /label="yqfT CDS" gene 2177765..2178019 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /label="yqfT gene" downshifts 2178006 /Source="Nicolas_upshifts" /id="D1303" /incds=0 /nref=12 /ntot=72 /MaxReadThrough="3.97414" /MaxDrop="7.03976" /score="24.5413663" /energy="-9.8" /TU="U1953" /idTUdmin="U1955" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2178046..2178939) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /EC_number="3.1.21.2" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type IV apurinic/apyrimidinic endonuclease" /protein_id="NP_390392.1" /db_xref="EnsemblGenomes-Gn:BSU25130" /db_xref="EnsemblGenomes-Tr:CAB14443" /db_xref="GOA:P54476" /db_xref="InterPro:IPR001719" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR018246" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11665" /db_xref="UniProtKB/Swiss-Prot:P54476" /translation="MLRIGSHVSMSGKHMLLAASQEAVSYGANTFMIYTGAPQNTRRK KIEDLNIEAGRAHMQENGIDEIIVHAPYIINIGNTTNPSTFELGVDFLRSEIERTAAI GAKQIVLHPGAHVGAGAEAGIKKIIEGLNEVIDPNQNVQIALETMAGKGSECGRSFEE LAQIIEGVTHNEQLSVCFDTCHTHDAGYNIVEDFDGVLNEFDKIIGIDRIKVLHINDS KNVKGARKDRHENIGFGEIGFDALQYVVHHEQLKDIPKILETPYVGEDKKNKKPPYRF EIEMLKEKQFDDTLLEKILQQ*" /label="nfo CDS" gene complement(2178046..2178939) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /label="nfo gene" S_feature 2178051..2178852 /Source="Nicolas_S_feature" /locus_tag="new_2593286_2594087" /HighExp="S6, S7, C30, S8, S5, G135, C90, Gly, LoTm, Sw" /AntisenseName="nfo" /AntisenseCor="-0.36683479556464399" /AntisenseRegPval="-9.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S944" downshifts complement(2178067) /Source="Nicolas_upshifts" /id="D1304" /incds=0 /nref=46 /ntot=187 /MaxReadThrough="4.82641" /MaxDrop="6.05328" /score="16.7756411" /energy="-9.8" /TU="U1956" /idTUdmin="U1952" /TUdmin="-1870" /isTUend="FALSE" /label="downshifts" CDS complement(2178949..2180265) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 16352840, 18203828, 20572937, 23175651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16352840, 18203828, 20572937, 23175651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_390393.1" /db_xref="EnsemblGenomes-Gn:BSU25140" /db_xref="EnsemblGenomes-Tr:CAB14444" /db_xref="GOA:P54475" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030881" /db_xref="SubtiList:BG11664" /db_xref="UniProtKB/Swiss-Prot:P54475" /translation="MKETKFELYELKPFIIDAVHRLGFYEPTDIQKRLIPAVLKKESV IGQSQTGTGKTHAYLLPLLNKIDPAKDVVQVVITAPTRELANQIYQEALKITQGEEGS QIRSKCFIGGTDKQKSIDKLKIQPHLVVGTPGRIADLIKEQALSVHKAESLVIDEADL MLDMGFLADVDYIGSRMPEDLQMLVFSATIPEKLKPFLKKYMENPKYAHVEPKQVTAA KIEHILIPSKHRDKDKLLFDIMSHLNPYLGIVFANTKNTADHIAQYLTGKGMKIGLLH GGLTPRERKKVMKQINDLEFTYIIATDLAARGIDIKGVSHVINYELPDDLDFYVHRVG RTARAGSSGQAMTIYELTDEDALVRLEKMGIEFEYLELEKGEWKKGDDRQRRKKRKKT PNEADEIAHRLVKKPKKVKPGYKKKMSYEMEKIKKKQRRNQSKKRK*" /label="cshB CDS" gene complement(2178949..2180265) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /label="cshB gene" promotor_-10 complement(2180301..2180320) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2180312) /Source="Nicolas_upshifts" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2180336..2180340) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2180369..2180378 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2180390 /Source="Nicolas_upshifts" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2180392..2180411 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2180434..2181177 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390394.1" /db_xref="EnsemblGenomes-Gn:BSU25150" /db_xref="EnsemblGenomes-Tr:CAB14445" /db_xref="InterPro:IPR025571" /db_xref="SubtiList:BG11663" /db_xref="UniProtKB/Swiss-Prot:P54474" /translation="MFSPQQPMRNYPQPGPPRPMPNQRMMGRRPPNMRGPSFGAQQQG FQQAGQFLPQANAGARNGAGAGGGLKGMLSRFLPGGGGAGSAGVPGIPGAGAAASGGA GLQGIQNIANPASLSSMLGNVQKVLGMAQQVTPMIQQYGPLVRNLPAMMKLYSQLSKS DDTETEANEESEKQSVSEESSEKEKETETKTSDGNKKSKPKSSSLPKKSKTTDNKEQE LKTSAPKKKEAASPAPKRTSGSSKPRLYI*" /label="yqfQ CDS" gene 2180434..2181177 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /label="yqfQ gene" downshifts 2181159 /Source="Nicolas_upshifts" /id="D1305" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="5.46594" /MaxDrop="3.2445" /score="4.32537428" /energy="-6.8" /TU="U1957" /idTUdmin="U1957" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" promotor_-35 2181181..2181188 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2181202..2181221 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2181204..2181299 /Source="Nicolas_S_feature" /locus_tag="new_2596439_2596534" /HighExp="S8, S7, S6, Cold, H2O2, Salt, dia15, G180, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S945" upshifts 2181204 /Source="Nicolas_upshifts" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="upshifts" CDS 2181300..2182244 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /EC_number="1.17.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12706830, 15381396, 15469281, 17458547, 27169371; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase" /protein_id="NP_390395.2" /db_xref="EnsemblGenomes-Gn:BSU25160" /db_xref="EnsemblGenomes-Tr:CAB14446" /db_xref="GOA:P54473" /db_xref="InterPro:IPR003451" /db_xref="SubtiList:BG11662" /db_xref="UniProtKB/Swiss-Prot:P54473" /translation="MDVIKISPRGYCYGVVDAMVIAKNASLDKSLPRPIYILGMIVHN KHVTDAFEEEGIFTLDGSNRLDILKQVDKGTVIFTAHGVSPEVRRIAEEKGLVAIDAT CPDVTKTHNLILEMKEKGYHVIYIGKKGHPEPEGAVGVAPEIVHLVETEEDVKNLDIQ SEKLIVTNQTTMSQWDVHDIMELVKEKYPHVEYHQEICLATQVRQEAVSEQAKKADLT IVVGDPKSNNSNRLAQVSEEIAGTKAYRIGDLSELKLEWLKGVNTVAVTAGASTPTPI TKEVIRFLEQFDHEDPSTWTTEHNIPLKKILPKVKAKN*" /label="ispH CDS" gene 2181300..2182244 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /label="ispH gene" downshifts 2182215 /Source="Nicolas_upshifts" /id="D1306" /incds=0 /nref=106 /ntot=243 /MaxReadThrough="4.04288" /MaxDrop="5.66904" /score="29.529951" /energy="-12.2" /TU="U1958" /idTUdmin="U1957" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2182267..2183388) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17187687, 17586767; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative GTP cyclohydrolase" /protein_id="NP_390396.1" /db_xref="EnsemblGenomes-Gn:BSU25170" /db_xref="EnsemblGenomes-Tr:CAB14447" /db_xref="GOA:P54472" /db_xref="InterPro:IPR002678" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017221" /db_xref="InterPro:IPR036069" /db_xref="SubtiList:BG11661" /db_xref="UniProtKB/Swiss-Prot:P54472" /translation="MAKSVNGQQIIQLFEQFSPKAYAVEGDKIGLQIGTLNKPIKNVM VTLDVLESVIDEAIEKEVDLIIAHHPPIFRSLKHISTDQPAGRLIEKCLKHDIAVYAA HTNLDVADGGVNDLLAEALELSETEVLAPTYTDPLKKLAVYVPKEYEEQVRAALGNAG AGHIGEYSHCAFSSEGIGSFKPLDGAKPFIGEVGELELVHEVRLETVFPKSVEKAVIN AMIKSHPYEEVAYDIYPVEQTPAEKGLGRVGTLKNEMTLKEFALFVKDKLDVNGVRMV GDADSMVKKVAVLGGDGNKYIHHAKRKGADVYVTGDLYFHVAHDAMMLGLNVVDPGHY AEKIMKEGVTRKLTSMCNDKKFGVNIFVSETDTNPFTFL*" /label="yqfO CDS" gene complement(2182267..2183388) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /label="yqfO gene" downshifts complement(2182292) /Source="Nicolas_upshifts" /id="D1307" /incds=0 /nref=63 /ntot=224 /MaxReadThrough="3.241" /MaxDrop="4.76436" /score="27.9821938" /energy="-12.2" /TU="NA" /idTUdmin="U1959" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2183381..2184031) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /EC_number="2.1.1.217" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:18420655, 27098549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18420655, 27098549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (adenine(22)-N(1))-methyltransferase" /protein_id="NP_390397.1" /db_xref="EnsemblGenomes-Gn:BSU25180" /db_xref="EnsemblGenomes-Tr:CAB14448" /db_xref="GOA:P54471" /db_xref="InterPro:IPR006901" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11660" /db_xref="UniProtKB/Swiss-Prot:P54471" /translation="MADIGSDHAYLPCYAVLNHKASGAIAGEITDGPFLSAKRQVEKS GLNSHISVRQGDGLEVIKKGEADAITIAGMGGALIAHILEAGKDKLTGKERLILQPNI HAVHIREWLYKERYALIDEVILEEDGKCYEVLVAEAGDRDAAYDGISLSAGMLVGPFL AKEKNAVFLKKWTQELQHTQSIYEQISQAADTEQNKQKLKELADRMELLKEVIDHG*" /label="trmK CDS" gene complement(2183381..2184031) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /label="trmK gene" S_feature complement(2184032..2184140) /Source="Nicolas_S_feature" /locus_tag="new_2599267_2599375_c" /HighExp="LBGexp, LBGtran, dia15, dia0, Lbexp, G150, G180, LBGstat, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S946" promotor_-10 complement(2184128..2184147) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2184140) /Source="Nicolas_upshifts" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2184142..2184255) /Source="Nicolas_S_feature" /locus_tag="new_2599377_2599490_c" /HighExp="Lbstat, M0t90, M9-stat, S2, T1.0H, T1.30H, T2.30H, T3.0H, S7, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S947" promotor_-35 complement(2184163..2184167) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2184288..2184650) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10024472, 10473570, 11361075, 15995641, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024472, 10473570, 11361075, 15995641, 19222757; Product type c: carrier" /codon_start=1 /transl_table=11 /product="cytochrome c550" /protein_id="NP_390398.1" /db_xref="EnsemblGenomes-Gn:BSU25190" /db_xref="EnsemblGenomes-Tr:CAB14449" /db_xref="GOA:P24469" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10315" /db_xref="UniProtKB/Swiss-Prot:P24469" /translation="MKWNPLIPFLLIAVLGIGLTFFLSVKGLDDSREIASGGESKSAE KKDANASPEEIYKANCIACHGENYEGVSGPSLKGVGDKKDVAEIKTKIEKGGNGMPSG LVPADKLDDMAEWVSKIK*" /label="cccA CDS" gene complement(2184288..2184650) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /label="cccA gene" downshifts complement(2184300) /Source="Nicolas_upshifts" /id="D1308" /incds=0 /nref=3 /ntot=88 /MaxReadThrough="4.32389" /MaxDrop="3.4795" /score="-4.13120914" /energy="-7.6" /TU="U1961,U1962" /idTUdmin="U1968" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-35 2184646..2184650 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2184658..2184672 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2184679 /Source="Nicolas_upshifts" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2184687..2184706) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2184689) /Source="Nicolas_upshifts" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2184691..2184812) /Source="Nicolas_S_feature" /locus_tag="new_2599926_2600047_c" /HighExp="Lbstat, T3.0H, T1.30H, M9-stat, T2.30H, T1.0H, T2.0H, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S948" promotor_-35 complement(2184718..2184725) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2184801..2184820) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2184809..2184828 /Source="Nicolas_upshift_promotors" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2184812) /Source="Nicolas_upshifts" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2184814..2184953) /Source="Nicolas_S_feature" /locus_tag="new_2600049_2600188_c" /HighExp="Lbstat, S8, S1, S7, G/S, BT, Mal, Gly, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S949" S_feature 2184815..2184919 /Source="Nicolas_S_feature" /locus_tag="new_2600050_2600154" /HighExp="T2.30H, M9-stat, T3.0H, T1.30H, T2.0H, T1.0H, T3.30H, T4.0H, M0t90, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S950" upshifts 2184815 /Source="Nicolas_upshifts" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2184834..2184840) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2184883..2184890 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2184904..2184923 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2184921..2187070 /Source="Nicolas_S_feature" /locus_tag="new_2600156_2602305" /HighExp="S2, T4.0H, T5.0H, Lbstat, M9-stat, T3.30H, S8, T3.0H, C30, T2.0H" /AntisenseName="sigA" /AntisenseCor="-0.16938350693676901" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S951" upshifts 2184921 /Source="Nicolas_upshifts" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2184979..2186094) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12455702, 12682299, 14527287, 15060039, 15670950, 28648455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12455702, 12682299, 14527287, 15060039, 15670950, 28648455; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase major sigma-43 factor (sigma-A)" /protein_id="NP_390399.2" /db_xref="EnsemblGenomes-Gn:BSU25200" /db_xref="EnsemblGenomes-Tr:CAB14450" /db_xref="GOA:P06224" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007127" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR009042" /db_xref="InterPro:IPR012760" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR028630" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10314" /db_xref="UniProtKB/Swiss-Prot:P06224" /translation="MADKQTHETELTFDQVKEQLTESGKKRGVLTYEEIAERMSSFEI ESDQMDEYYEFLGEQGVELISENEETEDPNIQQLAKAEEEFDLNDLSVPPGVKINDPV RMYLKEIGRVNLLSAKEEIAYAQKIEEGDEESKRRLAEANLRLVVSIAKRYVGRGMLF LDLIQEGNMGLMKAVEKFDYRKGYKFSTYATWWIRQAITRAIADQARTIRIPVHMVET INKLIRVQRQLLQDLGREPTPEEIAEDMDLTPEKVREILKIAQEPVSLETPIGEEDDS HLGDFIEDQEATSPSDHAAYELLKEQLEDVLDTLTDREENVLRLRFGLDDGRTRTLEE VGKVFGVTRERIRQIEAKALRKLRHPSRSKRLKDFLE*" /label="sigA CDS" gene complement(2184979..2186094) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /label="sigA gene" downshifts complement(2184998) /Source="Nicolas_upshifts" /id="D1309" /incds=0 /nref=118 /ntot=198 /MaxReadThrough="4.93947" /MaxDrop="6.16048" /score="4.75833607" /energy="-11.7" /TU="U1966,U1968,U1969,U1970,U1972,U1973" /idTUdmin="U1970" /TUdmin="-287" /isTUend="FALSE" /label="downshifts" S_feature complement(2186095..2186292) /Source="Nicolas_S_feature" /locus_tag="new_2601330_2601527_c" /HighExp="BC, Cold, SMMPr, S1, BI, G135, C30, Lbstat, S5, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S952" CDS complement(2186293..2188104) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /EC_number="2.7.7.-" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3100394, 9387153, 12682299, 16036556, 28386108; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA primase" /protein_id="NP_390400.2" /db_xref="EnsemblGenomes-Gn:BSU25210" /db_xref="EnsemblGenomes-Tr:CAB14451" /db_xref="GOA:P05096" /db_xref="InterPro:IPR002694" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR006295" /db_xref="InterPro:IPR013264" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR019475" /db_xref="InterPro:IPR030846" /db_xref="InterPro:IPR034151" /db_xref="InterPro:IPR036185" /db_xref="InterPro:IPR036977" /db_xref="InterPro:IPR037068" /db_xref="PDB:5GUJ" /db_xref="SubtiList:BG10313" /db_xref="UniProtKB/Swiss-Prot:P05096" /translation="MGNRIPDEIVDQVQKSADIVEVIGDYVQLKKQGRNYFGLCPFHG ESTPSFSVSPDKQIFHCFGCGAGGNVFSFLRQMEGYSFAESVSHLADKYQIDFPDDIT VHSGARPESSGEQKMAEAHELLKKFYHHLLINTKEGQEALDYLLSRGFTKELINEFQI GYALDSWDFITKFLVKRGFSEAQMEKAGLLIRREDGSGYFDRFRNRVMFPIHDHHGAV VAFSGRALGSQQPKYMNSPETPLFHKSKLLYNFYKARLHIRKQERAVLFEGFADVISA VSSDVKESIATMGTSLTDDHVKILRRNVEEIILCYDSDKAGYEATLKASELLQKKGCK VRVAMIPDGLDPDDYIKKFGGEKFKNDIIDASVTVMAFKMQYFRKGKNLSDEGDRLAY IKDVLKEISTLSGSLEQEVYVKQLASEFSLSQESLTEQLSVFSKQNKPADNSGETKTR RAHLTTKARQKRLRPAYENAERLLLAHMLRDRSVIKKVIDRVGFQFNIDEHRALAAYL YAFYEEGAELTPQHLMARVTDDHISQLLSDILMLQVNQELSEAELSDYVKKVLNQRNW SMIKEKEAERAEAERQKDFLRAASLAQEIVTLNRSLK*" /label="dnaG CDS" gene complement(2186293..2188104) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /label="dnaG gene" promotor_-35 2187699..2187705 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2187715 /Source="Nicolas_upshifts" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2187717..2187736 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2187744..2188040 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 9864351" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_054587.1" /db_xref="EnsemblGenomes-Gn:BSU25220" /db_xref="EnsemblGenomes-Tr:CAE01462" /db_xref="GOA:Q7WY63" /db_xref="SubtiList:BG14178" /db_xref="UniProtKB/Swiss-Prot:Q7WY63" /translation="MPQPFFVLQKTLAGLRNGLLYHLENQFGICQQGEKPTRQKNSLP SALKKRKHCRPLRSQSNEKSVCRAIRKTKVCFLHEKDRVQSSFGLASLIEHNHL*" /label="antE CDS" gene 2187744..2188040 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /label="antE gene" CDS complement(2188138..2188632) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9387153, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390401.2" /db_xref="EnsemblGenomes-Gn:BSU25230" /db_xref="EnsemblGenomes-Tr:CAB14452" /db_xref="InterPro:IPR003791" /db_xref="SubtiList:BG10312" /db_xref="UniProtKB/Swiss-Prot:P17868" /translation="MEGWRITLLNEQEKTIFVDADACPVKDEILQTASEYEVQVLFVA SFEHYQLSRSNEEKWKYVDPHKEAADLYIANHVKPGDIVVTQDIGLASLLLNRNVSVM SERGRLYKEDTIDFALEGRHFSGKQRRKGVYAKGPKKLNKEDRERFITLLQKILSNDE GILH*" /label="yqxD CDS" gene complement(2188138..2188632) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /label="yqxD gene" promotor_-10 complement(2188605..2188623) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2188616) /Source="Nicolas_upshifts" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2188633..2188746) /Source="Nicolas_S_feature" /locus_tag="new_2603868_2603981_c" /HighExp="S5, S4, S6, S7, S8, S3, Etha, dia15, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S953" promotor_-35 complement(2188635..2188643) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-35 2188641..2188646 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2188662..2188680 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2188677 /Source="Nicolas_upshifts" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2188731..2188749) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2188746) /Source="Nicolas_upshifts" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2188748..2188825) /Source="Nicolas_S_feature" /locus_tag="new_2603983_2604060_c" /HighExp="Etha, G180, G135, G150, LBGtran, LBGexp, dia15, H2O2, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S954" promotor_-35 complement(2188765..2188770) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2188791..2188810) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2188825) /Source="Nicolas_upshifts" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2188826..2188829) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2188886..2189698) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 20044937" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 20044937; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional ADP-dependent kinase-Pi-dependent pyrophosphorylase / positive regulator of gluconeogenesis" /protein_id="NP_390402.1" /db_xref="EnsemblGenomes-Gn:BSU25240" /db_xref="EnsemblGenomes-Tr:CAB14453" /db_xref="GOA:P54470" /db_xref="InterPro:IPR005177" /db_xref="InterPro:IPR026565" /db_xref="SubtiList:BG11659" /db_xref="UniProtKB/Swiss-Prot:P54470" /translation="MNNRIIYVVSDSVGETAELVVKAALSQFNGSADDTHVRRIPYVE DIGTINEVISLAKADGGIICFTLVVPEIREYLIAEAEKANVLYYDIIGPLIDKMETAY GLTAKYEPGRVRQLDEDYFKKVEAIEFAVKYDDGRDPRGILKADIVLIGVSRTSKTPL SQYLAHKRLKVANVPIVPEVDPPEELFNVDPKKCIGLKISPDKLNHIRKERLKSLGLN DKAIYANINRIKEELEYFEKIVDRIGCQVVDVSNKAVEETANIIHHLKTKNI*" /label="ppsR CDS" gene complement(2188886..2189698) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /label="ppsR gene" CDS complement(2189724..2190362) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of gluconeogenesis" /protein_id="NP_390403.1" /db_xref="EnsemblGenomes-Gn:BSU25250" /db_xref="EnsemblGenomes-Tr:CAB14454" /db_xref="GOA:O34994" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016842" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3FV6" /db_xref="PDB:3FWR" /db_xref="PDB:3FWS" /db_xref="SubtiList:BG13768" /db_xref="UniProtKB/Swiss-Prot:O34994" /translation="MSTIELNKRQEHILQIVKENGPITGEHIAEKLNLTRATLRPDLA ILTMSGFLEARPRVGYFYTGKTGTQLLADKLKKLQVKDFQSIPVVIHENVSVYDAICT MFLEDVGTLFVVDRDAVLVGVLSRKDLLRASIGQQELTSVPVHIIMTRMPNITVCRRE DYVMDIAKHLIEKQIDALPVIKDTDKGFEVIGRVTKTNMTKILVSLSENEIL*" /label="ccpN CDS" gene complement(2189724..2190362) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /label="ccpN gene" S_feature complement(2190363..2190494) /Source="Nicolas_S_feature" /locus_tag="new_2605598_2605729_c" /HighExp="G135, dia5, G180, G150, dia15, H2O2, LBGexp, Lbexp, Oxctl, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999, 0.998" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S955" promotor_-10 complement(2190488..2190507) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" CDS complement(2190495..2192534) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (beta subunit)" /protein_id="NP_390404.2" /db_xref="EnsemblGenomes-Gn:BSU25260" /db_xref="EnsemblGenomes-Tr:CAB14455" /db_xref="GOA:P54381" /db_xref="InterPro:IPR006194" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR015944" /db_xref="SubtiList:BG11658" /db_xref="UniProtKB/Swiss-Prot:P54381" /translation="MSKQDLLLEIGLEEMPARFLNESMVQLGDKLTGWLKEKNITHGE VKLFNTPRRLAVFVKDVAEKQDDIKEEAKGPAKKIALDADGNWTKAAIGFSKGQGANV EDLYIKEVKGIEYVFVQKFQAGQETKSLLPELSGLITSLHFPKNMRWGNEDLRYIRPI KWIVALFGQDVIPFSITNVESGRTTQGHRFLGHEVSIESPSAYEEQLKGQHVIADPSV RKQMIQSQLETMAAENNWSIPVDEDLLDEVNHLVEYPTALYGSFESEFLSIPEEVLVT TMKEHQRYFPVKDKNGDLLPHFITVRNGNSHAIENVARGNEKVLRARLSDASFFYKED QKLNIDANVKKLENIVFHEELGSLADKVRRVTSIAEKLAVRLQADEDTLKHVKRAAEI SKFDLVTHMIYEFPELQGIMGEKYARMLGEDEAVAAAVNEHYMPRSAGGETPSTFTGA VVAMADKLDTIASFFSIGVIPTGSQDPYGLRRQASGIVAILLDRNWGISFEELLTFVQ TDKENELLDFFTQRLKYVLNAEQIRHDVIDAVLESSELEPYSALHKAQVLEQKLGAPG FKETAEALGRVISISKKGVRGDIQPDLFENEYEAKLFDAYQTAKQNLQENFSKKDYEA ALASLAALKEPIDAYFDHTMVIADNESLKANRLAQMVSLADEIKSFANMNALIVK*" /label="glyS CDS" gene complement(2190495..2192534) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /label="glyS gene" upshifts complement(2190497) /Source="Nicolas_upshifts" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2190522..2190529) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" downshifts complement(2190541) /Source="Nicolas_upshifts" /id="D1310" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="6.14024" /MaxDrop="3.62589" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" downshifts complement(2190607) /Source="Nicolas_upshifts" /id="D1311" /incds=1 /nref=10 /ntot=162 /MaxReadThrough="6.17154" /MaxDrop="3.30313" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1386" /isTUend="FALSE" /label="downshifts" CDS complement(2192527..2193414) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390405.1" /db_xref="EnsemblGenomes-Gn:BSU25270" /db_xref="EnsemblGenomes-Tr:CAB14456" /db_xref="GOA:P54380" /db_xref="InterPro:IPR002310" /db_xref="InterPro:IPR006194" /db_xref="SubtiList:BG11657" /db_xref="UniProtKB/Swiss-Prot:P54380" /translation="MNIQDMILTLQKHWSSQGCVLMQAYDVEKGAGTMSPYTFLRSIG PEPWKVAYVEPSRRPADGRYGENPNRLYQHHQFQVIIKPSPDNIQELYLDSLRALGID PLEHDIRFVEDNWENPSLGCAGLGWEVWLDGMEITQFTYFQQVGGLECKPVSVEITYG IERLASYIQDKENVFDLEWTSGFTVKDLFMMAEYEHSVYTFETSDVDMLFQLFSTYEK EAIKQMDNGLVHPAYDYVLKCSHTFNLLDAKGAISVTERTGYIARVRNLARKVAKTYY EEREKLGFPMLKGEGSSHE*" /label="glyQ CDS" gene complement(2192527..2193414) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /label="glyQ gene" misc_RNA complement(2193497..2193671) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /product="T-box riboswitch controlling synthesis of glycine-tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201, 15890195, 26229106" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201, 15890195, 26229106; Product type n : RNA" /label="tboG RNA" gene complement(2193497..2193671) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /label="tboG gene" downshifts complement(2193531) /Source="Nicolas_upshifts" /id="D1312" /incds=0 /nref=70 /ntot=220 /MaxReadThrough="6.60948" /MaxDrop="5.42847" /score="18.9025126" /energy="-23.3" /TU="U1972,U1973,U1975" /idTUdmin="U1976" /TUdmin=178 /isTUend="FALSE" /label="downshifts" promotor_-35 2193646..2193651 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2193667..2193685 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2193675..2193694) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" S_feature 2193677..2195089 /Source="Nicolas_S_feature" /locus_tag="new_2608912_2610324" /HighExp="C30, S8, Gly, BT, G135, Fru, S6, C90, Lbstat, Mal" /AntisenseName="recO" /AntisenseCor="0.22892689952134901" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S956" upshifts 2193677 /Source="Nicolas_upshifts" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2193687) /Source="Nicolas_upshifts" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2193709..2193716) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2193711..2194478) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10323239, 15186413, 16061691, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10323239, 15186413, 16061691, 26001966; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA double strand break repair and homologous recombination factor" /protein_id="NP_390406.2" /db_xref="EnsemblGenomes-Gn:BSU25280" /db_xref="EnsemblGenomes-Tr:CAB14457" /db_xref="GOA:P42095" /db_xref="InterPro:IPR003717" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022572" /db_xref="SubtiList:BG11189" /db_xref="UniProtKB/Swiss-Prot:P42095" /translation="MLTKCEGIVLRTNDYGETNKIVTLLTREHGKIGVMARGAKKPNS RLSAVSQPFLYGSFLMQKTSGLGTLQQGEMILSMRGIREDLFLTAYAAYVAELVDRGT EEKKPNPYLFEFILESLKQLNEGTDPDVITFIVQMKMLGVMGLYPELNHCVHCKSQDG TFHFSVRDNGFICHRCFEKDPYRIPIKPQTARLLRLFYYFDLSRLGNVSLKEETKAEL KQVIDLYYEEYSGLYLKSKRFLDQMESMKHLMGENKS*" /label="recO CDS" gene complement(2193711..2194478) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /label="recO gene" CDS complement(2194515..2194658) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097761.1" /db_xref="EnsemblGenomes-Gn:BSU25289" /db_xref="EnsemblGenomes-Tr:CAX52661" /db_xref="InterPro:IPR025617" /db_xref="UniProtKB/Swiss-Prot:C0H452" /translation="MLNFTWNVFSQTGNVDTYLLFKELEKENMERPEELEDELARFDY PIL*" /label="yqzL CDS" gene complement(2194515..2194658) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /label="yqzL gene" S_feature complement(2194659..2194805) /Source="Nicolas_S_feature" /locus_tag="new_2609894_2610040_c" /HighExp="Lbstat, T1.30H, T2.0H, M9-stat, S2, T3.0H, S5, M0t90, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.999, 0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S957" CDS complement(2194806..2195711) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maturation of 16S RNA and assembly of 30S ribosomal subunit GTPase" /protein_id="NP_390407.1" /db_xref="EnsemblGenomes-Gn:BSU25290" /db_xref="EnsemblGenomes-Tr:CAB14458" /db_xref="GOA:P42182" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005662" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030388" /db_xref="SubtiList:BG11188" /db_xref="UniProtKB/Swiss-Prot:P42182" /translation="MTNESFKSGFVSIIGRPNVGKSTFLNRVIGQKIAIMSDKPQTTR NKVQGVLTTGTSQTIFIDTPGIHKPKHKLGDFMMKVAQNTLKEVDLILFMINAEEGYG KGDEFIIEKLQTMSTPVFLIVNKIDKIHPDQLLLLIDEYRKRYPFKEIVPISALEGNN IETLLAQIEAYLPEGPQFYPSDQVTDHPERFIISELIREKVLHLTREEIPHSIAVAIE SIKGQDNGSVHVAATIVVERDSQKGIVIGKKGSLLKEVGKRARADIEALLGSRVYLEL WVKVQKDWRNKMSQLRDFGFKEDEY*" /label="era CDS" gene complement(2194806..2195711) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /label="era gene" CDS complement(2195692..2196102) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /EC_number="3.5.4.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2526291, 8157589, 10217788, 11851403, 22720735, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2526291, 8157589, 10217788, 11851403, 22720735, 25890046; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidine/deoxycytidine deaminase" /protein_id="NP_390408.1" /db_xref="EnsemblGenomes-Gn:BSU25300" /db_xref="EnsemblGenomes-Tr:CAB14459" /db_xref="GOA:P19079" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR006262" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1JTK" /db_xref="PDB:1UWZ" /db_xref="PDB:1UX0" /db_xref="PDB:1UX1" /db_xref="SubtiList:BG10477" /db_xref="UniProtKB/Swiss-Prot:P19079" /translation="MNRQELITEALKARDMAYAPYSKFQVGAALLTKDGKVYRGCNIE NAAYSMCNCAERTALFKAVSEGDTEFQMLAVAADTPGPVSPCGACRQVISELCTKDVI VVLTNLQGQIKEMTVEELLPGAFSSEDLHDERKL*" /label="cdd CDS" gene complement(2195692..2196102) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /label="cdd gene" promotor_-10 complement(2196140..2196159) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2196151) /Source="Nicolas_upshifts" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2196153..2196220) /Source="Nicolas_S_feature" /locus_tag="new_2611388_2611455_c" /HighExp="Oxctl, H2O2, G180, G150, GM 120, S1, G135, Diami, LBGtran, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S958" promotor_-35 complement(2196174..2196177) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2196221..2196592) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /EC_number="2.7.1.66" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12923107, 17535816, 19935659, 28872301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenol kinase" /protein_id="NP_390409.2" /db_xref="EnsemblGenomes-Gn:BSU25310" /db_xref="EnsemblGenomes-Tr:CAB14460" /db_xref="GOA:P19638" /db_xref="InterPro:IPR000829" /db_xref="InterPro:IPR033717" /db_xref="InterPro:IPR036945" /db_xref="SubtiList:BG11040" /db_xref="UniProtKB/Swiss-Prot:P19638" /translation="MDSKDHRNELNRFFKSFVHAGRGIWETARTERNFQFHAAAACAV LICGFLVELSIIEWMIIFLLIGGMFSLELLNTAIEHTVDLITDKHHPLAKAAKDAAAG AVCVFAVISCIIGLLIFLPKL*" /label="unpK CDS" gene complement(2196221..2196592) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /label="unpK gene" CDS complement(2196573..2197046) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16511207, 16818608, 19181801, 20639334, 20807199, 23273979, 23638028, 24511998, 24901994, 28031281; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease involved in 70S ribosomes quality control" /protein_id="NP_390410.2" /db_xref="EnsemblGenomes-Gn:BSU25320" /db_xref="EnsemblGenomes-Tr:CAB14461" /db_xref="GOA:P46347" /db_xref="InterPro:IPR002036" /db_xref="InterPro:IPR020549" /db_xref="InterPro:IPR023091" /db_xref="SubtiList:BG11656" /db_xref="UniProtKB/Swiss-Prot:P46347" /translation="MSLLIDIVDETGSVSEEMLKEVENLLQFAAEREGVQDQAEVSVT IVSNDDIHQINKEYRGKDAPTDVISFALEEEGEGEIEIVGAEMPPVLGDIIISADRTR EQAEEYNHSFKRELGFLAVHGFLHLLGYDHMTKEEEEEMFTKQKELLDAYGLKRS*" /label="rnrY CDS" gene complement(2196573..2197046) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /label="rnrY gene" CDS complement(2197047..2199182) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751502, 26240071, 27378384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751502, 26240071, 27378384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="c-di-AMP-degrading phosphodiesterases" /protein_id="NP_390411.1" /db_xref="EnsemblGenomes-Gn:BSU25330" /db_xref="EnsemblGenomes-Tr:CAB14462" /db_xref="GOA:P46344" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR011621" /db_xref="InterPro:IPR011624" /db_xref="SubtiList:BG11655" /db_xref="UniProtKB/Swiss-Prot:P46344" /translation="MLKKKAKTKSSSKKWSSFKNARSMHVLLYLLLAAIMFALLFVHV KPETLDLDLFSVSDKTIYAPATVEDQKATEEKKQAAEDAVEDQYTLKKEYTDNRIDLV SSIFDSISEVKKSSEEGSKSPSEKSMVKSVKDKLTSDVNDSISEDSIKTLLKADSEDF SFVRDTVITAVNTVMSSEIPSDKLSDAKDKVEKELKSNSIPSKYLGAATEIGRFAIIP NYVFDPKATEAKRQEASDNVQQVQIKQGQVLVEENDLIDREVYRKLELTGLLNNSNLF KPISGLLIMIGLFIATLVYYFEKQKQNLKFKNQSILLFSIITTLLLVIMEVVSLFQKM EYNNIGYLVPIAAGAILIKLLMNERIAILGSIILAICGSMMFNQGVTGTFNYVIGIYY LISGISGVLFLGKHNARSKILQTGLFVAFINMVVVLSLLLIQNTALSGLEIGTLMLMG VVSGFASSVLIIGLMPFFETGFGILSTMRLLELSNPNHPLLRKILTETPGTYHHSVMV ANLSEAACEAVGANGLLARVGAYYHDLGKTKRPQYFIENQMNIDNPHDKLSPQLSKNI IISHTTDGANMLRSYKFPKELVDIAEQHHGTSLLKFFYYKAKEKGDQITEEEFRYPGP KPQSKEAAIISVADSVEAAVRSMHNPNPERIEKLVRGIISDKLQDGQFSECDLTFKEL DTIAKTLCATLKGIFHSRIEYPEATKKVK*" /label="pgpH CDS" gene complement(2197047..2199182) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /label="pgpH gene" promotor_-35 2199026..2199031 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2199046 /Source="Nicolas_upshifts" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2199047..2199065 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2199261..2200220) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12762842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12762842; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="phosphate starvation-induced protein" /protein_id="NP_390412.2" /db_xref="EnsemblGenomes-Gn:BSU25340" /db_xref="EnsemblGenomes-Tr:CAB14476" /db_xref="GOA:P46343" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11337" /db_xref="UniProtKB/Swiss-Prot:P46343" /translation="MTEHLLAMNQKLKNPDEALSLFGNQDSFLKLMEKDLNLNIITRG ETIYVSGDDESFQIADRLLGSLLALIRKGIEISERDVIYAIKMAKKNELEYFESMYEE EITKNAKGKSIRVKTMGQREYVAAMKRNDLVFGIGPAGTGKTYLAVVKAVHALKNGHI KKIILTRPAVEAGESLGFLPGDLKEKVDPYLRPLYDALHDVLGADHTERLMERGIIEI APLAYMRGRTLDDAYVILDEAQNTTPAQMKMFLTRLGFGSKMIITGDVSQIDLPKGVK SGLAVAKEMLKGIDGISMIELDQTDVVRHPLVAKIIEAYDKQN*" /label="phoH CDS" gene complement(2199261..2200220) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /label="phoH gene" downshifts complement(2199276) /Source="Nicolas_upshifts" /id="D1313" /incds=0 /nref=1 /ntot=63 /MaxReadThrough="6.04676" /MaxDrop="4.50442" /score="9.12152318" /energy="-13.1" /TU="U1975,U1976,U1977" /idTUdmin="U1978" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" CDS complement(2200217..2201413) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14523133, 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage IV sporulation protein; putative UDP-glucose-4-epimerase" /protein_id="NP_390413.2" /db_xref="EnsemblGenomes-Gn:BSU25350" /db_xref="EnsemblGenomes-Tr:CAB14477" /db_xref="GOA:P54469" /db_xref="InterPro:IPR010690" /db_xref="SubtiList:BG11654" /db_xref="UniProtKB/Swiss-Prot:P54469" /translation="MKNKWLSFFSGKVQLELTGRGIERLLNECTRQGIPVFHVKKKKE AVSLYIQLQDVHAFRRVRSKFKCKARFINRKGFPFLLLKSKLNIGFTIGFAIFFILLF LLSNMVWKIDVTGAKPETEHQMRQHLNEIGVKKGRLQFLMMSPEKIQKSLTNGIDNIT WVGVDLKGTTIHMKVVEKNEPEKEKYVSPRNIVAKKKATITRMFVQKGQPMAAIHDHV EKGQLLVSGLIGSEDHQQEVASKAEIYGETWYRSEVTVPLETLFNVYTGKVRTKHKLS FGSLAIPIWGMTFKKEELKHPKTEQEKHSLHFLGFKLPVSYVKEQTRESEEALRKYTK EEAVQEGIKLGKQDVEDKIGENGEVKSEKVLHQTVENGKVKLIILYQVIEDIVQTTPI VRETEE*" /label="yqfD CDS" gene complement(2200217..2201413) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /label="yqfD gene" promotor_-10 complement(2200284..2200303) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2200289) /Source="Nicolas_upshifts" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2200317..2200324) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2200364..2200382) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-10" upshifts complement(2200376) /Source="Nicolas_upshifts" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="upshifts" promotor_-35 complement(2200397..2200403) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-35" upshifts complement(2200591) /Source="Nicolas_upshifts" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="upshifts" promotor_-10 complement(2200605..2200616) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-10" promotor_-35 complement(2200631..2200637) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-35" CDS complement(2201432..2201713) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12662922" /codon_start=1 /transl_table=11 /product="conserved sporulation protein of unknown function" /protein_id="NP_390414.1" /db_xref="EnsemblGenomes-Gn:BSU25360" /db_xref="EnsemblGenomes-Tr:CAB14478" /db_xref="InterPro:IPR022476" /db_xref="InterPro:IPR022477" /db_xref="SubtiList:BG11653" /db_xref="UniProtKB/Swiss-Prot:P54468" /translation="MGQRKNRMKAWLTRALEIPPDVMMDLPRITMVGRLHIYIENHRG LLLFSENEVRLMLKQGQCIISGKNFVIKAILPEEILLEGTIDVVRYVES*" /label="yqfC CDS" gene complement(2201432..2201713) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /label="yqfC gene" CDS complement(2201770..2202189) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390415.2" /db_xref="EnsemblGenomes-Gn:BSU25370" /db_xref="EnsemblGenomes-Tr:CAB14479" /db_xref="GOA:P54467" /db_xref="InterPro:IPR016788" /db_xref="SubtiList:BG11652" /db_xref="UniProtKB/Swiss-Prot:P54467" /translation="MEDLLTNPLIIAAIIGIISAIFGKKSKEEKQNSQKRKKPQHVQS ASPQKKQSKEDAPAPIPNRMEQARREAEERRRETARNLKGLERDLAAAKQKTVYTKQK MLQVNKDTVVQGIVLGEVFGPPRAKKPHRTMRPARKN*" /label="yqfB CDS" gene complement(2201770..2202189) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /label="yqfB gene" downshifts complement(2201784) /Source="Nicolas_upshifts" /id="D1314" /incds=0 /nref=232 /ntot=257 /MaxReadThrough="4.55662" /MaxDrop="7.47609" /score="-3.87904232" /energy="-16.8" /TU="U1978" /idTUdmin="U1980" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2202214..2203209) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12501411, 22753055" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12501411, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="flotillin-like protein involved in membrane lipid rafts" /protein_id="NP_390416.1" /db_xref="EnsemblGenomes-Gn:BSU25380" /db_xref="EnsemblGenomes-Tr:CAB14480" /db_xref="GOA:P54466" /db_xref="InterPro:IPR022853" /db_xref="SubtiList:BG11651" /db_xref="UniProtKB/Swiss-Prot:P54466" /translation="MDPSTLMILAIVAVAIIVLAVFFTFVPVMLWISALAAGVKISIF TLVGMRLRRVIPNRVVNPLIKAHKAGLNVGTNQLESHYLAGGNVDRVVNALIAAQRAN IELTFERCAAIDLAGRDVLEAVQMSVNPKVIETPFIAGVAMDGIEVKAKARITVRANI ERLVGGAGEETIVARVGEGIVSTIGSSDNHKKVLENPDMISQTVLGKGLDSGTAFEIL SIDIADVDIGKNIGAILQTDQAEADKNIAQAKAEERRAMAVAQEQEMRARVEEMRAKV VEAEAEVPLAMAEALREGNIGVMDYMNIKNIDADTEMRDSFGKLTKDPSDEDRKS*" /label="floA CDS" gene complement(2202214..2203209) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /label="floA gene" CDS complement(2203231..2204544) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22753055; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound peptidase of unkwnown function" /protein_id="NP_390417.1" /db_xref="EnsemblGenomes-Gn:BSU25390" /db_xref="EnsemblGenomes-Tr:CAB14481" /db_xref="GOA:P54465" /db_xref="InterPro:IPR002810" /db_xref="InterPro:IPR002825" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11650" /db_xref="UniProtKB/Swiss-Prot:P54465" /translation="MLQIKGFRAALLGIFLLSLLGVQLNAKAEKQTVYVIPVEKNVEQ GLASFLSRSLQDAKDAHADHIILDINTPGGLVKSAIDMADLITESEIPVTAYVNKRAL SAGAYIALQADHIYMAPGGKMGAAAIVDGQGNAADQKAQSLWLAEMEDAAVKNNRDPK YALAMADPDIDAKEVGAPKGDLLTLNADKAIEVGYSEGTADNLSTLVKKLGFEKAQIS YAKESFAEKTARWLTNPVIVPILLTIAFLGLTVELFSPGVGLPGTAGLIALLLFFYGH LAAGLAGYETVLLFIAGVILILLEIFLPGGIIGLLGLGAIIASLFLAAGSFTVMAVSL LIASAVSITAFILLTRVLGKRMKFFKKLILNDSTNTESGYVSNQTRTDLMGKVGITFT PLRPSGTVIIDDERLDVVSEGSFTEKDKKVKVIKVEGSRIVVREI*" /label="nfeDA CDS" gene complement(2203231..2204544) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /label="nfeDA gene" promotor_-10 complement(2204580..2204595) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-10" upshifts complement(2204597) /Source="Nicolas_upshifts" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="upshifts" promotor_-35 complement(2204608..2204617) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-35" CDS complement(2204675..2205121) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17284460, 22720735, 25149203" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function with tRNA aminoacid amidase domain" /protein_id="NP_390418.1" /db_xref="EnsemblGenomes-Gn:BSU25400" /db_xref="EnsemblGenomes-Tr:CAB14482" /db_xref="GOA:P54464" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR019004" /db_xref="InterPro:IPR023168" /db_xref="PDB:1NG6" /db_xref="SubtiList:BG11649" /db_xref="UniProtKB/Swiss-Prot:P54464" /translation="MSLLERLNQDMKLYMKNREKDKLTVVRMVKASLQNEAIKLKKDS LTEDEELTVLSRELKQRKDSLQEFSNANRLDLVDKVQKELDILEVYLPEQLSEEELRT IVNETIAEVGASSKADMGKVMGAIMPKVKGKADGSLINKLVSSQLS*" /label="yqeY CDS" gene complement(2204675..2205121) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /label="yqeY gene" downshifts complement(2204688) /Source="Nicolas_upshifts" /id="D1315" /incds=0 /nref=248 /ntot=267 /MaxReadThrough="5.1355" /MaxDrop="8.31948" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1760 /isTUend="FALSE" /label="downshifts" downshifts complement(2204886) /Source="Nicolas_upshifts" /id="D1316" /incds=1 /nref=1 /ntot=34 /MaxReadThrough="8.99916" /MaxDrop="1.9798" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS complement(2205136..2205309) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 22720735, 23002217, 25035996" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 22720735, 23002217, 25035996; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S21" /protein_id="NP_390419.1" /db_xref="EnsemblGenomes-Gn:BSU25410" /db_xref="EnsemblGenomes-Tr:CAB14483" /db_xref="GOA:P21478" /db_xref="InterPro:IPR001911" /db_xref="InterPro:IPR018278" /db_xref="SubtiList:BG11648" /db_xref="UniProtKB/Swiss-Prot:P21478" /translation="MSKTVVRKNESLEDALRRFKRSVSKTGTLQEARKREFYEKPSVK RKKKSEAARKRKF*" /label="rpsU CDS" gene complement(2205136..2205309) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /label="rpsU gene" misc_feature 2205245..2205249 /Source="Nicolas_upshift_promotors" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2205250 /Source="Nicolas_upshifts" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2205370..2205389) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2205385) /Source="Nicolas_upshifts" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2205403..2205410) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2205428..2205433 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2205448 /Source="Nicolas_upshifts" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2205449..2205467 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2205482..2206405 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/anion cotransporter" /protein_id="NP_390420.2" /db_xref="EnsemblGenomes-Gn:BSU25420" /db_xref="EnsemblGenomes-Tr:CAB14484" /db_xref="GOA:P54463" /db_xref="InterPro:IPR003841" /db_xref="InterPro:IPR004633" /db_xref="SubtiList:BG11647" /db_xref="UniProtKB/Swiss-Prot:P54463" /translation="MLILISFTALILFFLAGMNMLRKGLISMAYSKIEERLLLFTDHP LKAFLISIVFTGILQSSSAFMVIVIGFVSAGVLSFKRTIPMILGTNVGSTFTTEFIAI KMDIVIWVLLIGGLLFFLTGRYPLKQLGTSFLGLGIIFFCISGFSHLAGPLTKLKTGA DVLYHVNDSNWSALLIGMVLTAIIHSSSVCIGILMSFMNEGIIGLTQAMSVVLGSNIG TCITAVMAAVSGGYAAKQTAYAHVVFNVLGVALVLPFLTAATGFVEQLSPDPAQKIAH FSLLFNVVTALLFLPLTNLFYRLIHLLIPAK*" /label="yqeW CDS" gene 2205482..2206405 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /label="yqeW gene" CDS complement(2206442..2207797) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA N(6)-threonylcarbamoyladenosine (t(6)A) methylthiotransferase" /protein_id="NP_390421.1" /db_xref="EnsemblGenomes-Gn:BSU25430" /db_xref="EnsemblGenomes-Tr:CAB14485" /db_xref="GOA:P54462" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006467" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR034557" /db_xref="SubtiList:BG11646" /db_xref="UniProtKB/Swiss-Prot:P54462" /translation="MATVAFHTLGCKVNHYETEAIWQLFKEAGYERRDFEQTADVYVI NTCTVTNTGDKKSRQVIRRAIRQNPDGVICVTGCYAQTSPAEIMAIPGVDIVVGTQDR EKMLGYIDQYREERQPINGVSNIMKARVYEELDVPAFTDRTRASLKIQEGCNNFCTFC IIPWARGLLRSRDPEEVIKQAQQLVDAGYKEIVLTGIHTGGYGEDMKDYNFAKLLSEL DTRVEGVKRIRISSIEASQITDEVIEVLDRSDKIVNHLHIPIQSGSNTVLKRMRRKYT MEFFADRLNKLKKALPGLAVTSDVIVGFPGETEEEFMETYNFIKEHKFSELHVFPYSK RTGTPAARMEDQVDENVKNERVHRLIALSDQLAKEYASQYENEVLEIIPEEAFKETEE ENMFVGYTDNYMKVVFKGTEDMIGKIVKVKILKAGYPYNEGQFVRVVEDEITEHMRLS S*" /label="mtaB CDS" gene complement(2206442..2207797) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /label="mtaB gene" downshifts complement(2206448) /Source="Nicolas_upshifts" /id="D1317" /incds=0 /nref=208 /ntot=260 /MaxReadThrough="1.95578" /MaxDrop="6.05381" /score="30.7201786" /energy="-11.3" /TU="NA" /idTUdmin="U1983" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2207797..2208567) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /EC_number="2.1.1.193" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9023197, 10383760, 14517985, 16014871, 16431987, 22925577, 24598751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylase of U1498 in 16S rRNA" /protein_id="NP_390422.1" /db_xref="EnsemblGenomes-Gn:BSU25440" /db_xref="EnsemblGenomes-Tr:CAB14486" /db_xref="GOA:P54461" /db_xref="InterPro:IPR006700" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1VHK" /db_xref="SubtiList:BG11645" /db_xref="UniProtKB/Swiss-Prot:P54461" /translation="MQRYFIELTKQQIEEAPTFSITGEEVHHIVNVMRMNEGDQIICC SQDGFEAKCELQSVSKDKVSCLVIEWTNENRELPIKVYIASGLPKGDKLEWIIQKGTE LGAHAFIPFQAARSVVKLDDKKAKKKRERWTKIAKEAAEQSYRNEVPRVMDVHSFQQL LQRMQDFDKCVVAYEESSKQGEISAFSAIVSSLPKGSSLLIVFGPEGGLTEAEVERLT EQDGVTCGLGPRILRTETAPLYALSAISYQTELLRGDQ*" /label="rsmE CDS" gene complement(2207797..2208567) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /label="rsmE gene" CDS complement(2208590..2209525) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17215866, 18611379; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 methyltransferase" /protein_id="NP_390423.2" /db_xref="EnsemblGenomes-Gn:BSU25450" /db_xref="EnsemblGenomes-Tr:CAB14487" /db_xref="GOA:P54460" /db_xref="InterPro:IPR004498" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11644" /db_xref="UniProtKB/Swiss-Prot:P54460" /translation="MKWSELSIHTTHEAVEPISNILHEAGASGVVIEDPLDLIKEREN VYGEIYQLDPNDYPDEGVIVKAYLPVNSFLGETVDGIKETINNLLLYNIDLGRNHITI SEVNEEEWATAWKKYYHPVKISEKFTIVPTWEEYTPVHTDELIIEMDPGMAFGTGTHP TTVLCIQALERFVQKGDKVIDVGTGSGILSIAAAMLEAESVHAYDLDPVAVESARLNL KLNKVSDIAQVKQNNLLDGIEGEHDVIVANILAEVILRFTSQAYSLLKEGGHFITSGI IGHKKQEVKEALEQAGFTIVEILSMEDWVSIIAKK*" /label="prmA CDS" gene complement(2208590..2209525) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /label="prmA gene" CDS complement(2209550..2210677) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10383760, 10658654, 16385044, 16952052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10383760, 10658654, 16385044, 16952052; Product type f: factor" /codon_start=1 /transl_table=11 /product="co-factor of molecular chaperone" /protein_id="NP_390424.2" /db_xref="EnsemblGenomes-Gn:BSU25460" /db_xref="EnsemblGenomes-Tr:CAB14488" /db_xref="GOA:P17631" /db_xref="InterPro:IPR001305" /db_xref="InterPro:IPR001623" /db_xref="InterPro:IPR002939" /db_xref="InterPro:IPR008971" /db_xref="InterPro:IPR012724" /db_xref="InterPro:IPR018253" /db_xref="InterPro:IPR036410" /db_xref="InterPro:IPR036869" /db_xref="SubtiList:BG10665" /db_xref="UniProtKB/Swiss-Prot:P17631" /translation="MSKRDYYEVLGVSKSASKDEIKKAYRKLSKKYHPDINKEAGSDE KFKEVKEAYETLSDDQKRAHYDQFGHTDPNQGFGGGGFGGGDFGGFGFDDIFSSIFGG GTRRRDPNAPRQGADLQYTMTLSFEDAAFGKETTIEIPREETCETCKGSGAKPGTNPE TCSHCGGSGQLNVEQNTPFGKVVNRRVCHHCEGTGKIIKNKCADCGGKGKIKKRKKIN VTIPAGVDDGQQLRLSGQGEPGINGGPAGDLFVVFHVRAHEFFERDGDDIYCEMPLTF AQAALGDEVEVPTLHGKVKLKIPAGTQTGTKFRLRGKGVQNVRGYGQGDQHIVVRVVT PTNLTDKQKDIIREFAEVSGNLPDEQEMSFFDKVKRAFKGD*" /label="dnaJ CDS" gene complement(2209550..2210677) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /label="dnaJ gene" misc_feature 2210594..2210597 /Source="Nicolas_upshift_promotors" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2210605 /Source="Nicolas_upshifts" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2210678..2210855) /Source="Nicolas_S_feature" /locus_tag="new_2625913_2626090_c" /HighExp="Heat, dia15, H2O2, Diami, G135, G150, G180, LPhT, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.357489" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S959" misc_RNA 2210717..2210807 /gene="surC" /locus_tag="BSU_misc_RNA_79" /product="sporulation-related small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surC RNA" gene 2210717..2210807 /gene="surC" /locus_tag="BSU_misc_RNA_79" /label="surC gene" CDS complement(2210877..2212712) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular chaperone, ATP-dependent" /protein_id="NP_390425.1" /db_xref="EnsemblGenomes-Gn:BSU25470" /db_xref="EnsemblGenomes-Tr:CAB14489" /db_xref="GOA:P17820" /db_xref="InterPro:IPR012725" /db_xref="InterPro:IPR013126" /db_xref="InterPro:IPR018181" /db_xref="InterPro:IPR029047" /db_xref="InterPro:IPR029048" /db_xref="PDB:2FZO" /db_xref="SubtiList:BG10664" /db_xref="UniProtKB/Swiss-Prot:P17820" /translation="MSKVIGIDLGTTNSCVAVLEGGEPKVIANAEGNRTTPSVVAFKN GERQVGEVAKRQSITNPNTIMSIKRHMGTDYKVEIEGKDYTPQEVSAIILQHLKSYAE SYLGETVSKAVITVPAYFNDAERQATKDAGKIAGLEVERIINEPTAAALAYGLDKTDE DQTILVYDLGGGTFDVSILELGDGVFEVRSTAGDNRLGGDDFDQVIIDHLVSEFKKEN GIDLSKDKMALQRLKDAAEKAKKDLSGVSSTQISLPFITAGEAGPLHLELTLTRAKFE ELSSHLVERTMGPVRQALQDAGLSASEIDKVILVGGSTRIPAVQEAIKKETGKEAHKG VNPDEVVALGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSK SQVFSTAADNQTAVDIHVLQGERPMSADNKTLGRFQLTDIPPAPRGVPQIEVSFDIDK NGIVNVRAKDLGTGKEQNITIKSSSGLSDEEIERMVKEAEENADADAKKKEEIEVRNE ADQLVFQTEKTLKDLEGKVDEEQVKKANDAKDALKAAIEKNEFEEIKAKKDELQTIVQ ELSMKLYEEAAKAQQAQGGANAEGKADDNVVDAEYEEVNDDQNKK*" /label="dnaK CDS" gene complement(2210877..2212712) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /label="dnaK gene" downshifts complement(2210900) /Source="Nicolas_upshifts" /id="D1318" /incds=0 /nref=130 /ntot=247 /MaxReadThrough="8.0737" /MaxDrop="4.023" /score="21.9400858" /energy="-13.4" /TU="U1983,U1985" /idTUdmin="U1984" /TUdmin=3565 /isTUend="FALSE" /label="downshifts" CDS complement(2212736..2213299) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nucleotide exchange factor for DnaK activity" /protein_id="NP_390426.1" /db_xref="EnsemblGenomes-Gn:BSU25480" /db_xref="EnsemblGenomes-Tr:CAB14490" /db_xref="GOA:P15874" /db_xref="InterPro:IPR000740" /db_xref="InterPro:IPR009012" /db_xref="InterPro:IPR013805" /db_xref="PDB:2G61" /db_xref="SubtiList:BG10663" /db_xref="UniProtKB/Swiss-Prot:P15874" /translation="MSEEKQTVEQNETEEQEIIEEQAAADEQQEETNESELLQNQINE LQGLLEEKENKLLRVQADFENYKRRSRLEMEASQKYRSQNIVTDLLPALDSFERALQV EADNEQTKSLLQGMEMVHRQLVEALKKEGVEAIEAVGQEFDPNLHQAVMQAEDENYGS NIVVEEMQKGYKLKDRVIRPSMVKVNQ*" /label="grpE CDS" gene complement(2212736..2213299) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /label="grpE gene" S_feature complement(2213300..2213370) /Source="Nicolas_S_feature" /locus_tag="new_2628535_2628605_c" /HighExp="LPhT, dia15, Heat, Etha, Diami, dia5, H2O2, T-0.40H, T0.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S960" CDS complement(2213371..2214402) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10555317, 12082092, 15109714, 16872404, 16585746, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10555317, 12082092, 15109714, 16872404, 16585746, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of heat-shock genes" /protein_id="NP_390427.1" /db_xref="EnsemblGenomes-Gn:BSU25490" /db_xref="EnsemblGenomes-Tr:CAB14491" /db_xref="GOA:P25499" /db_xref="InterPro:IPR002571" /db_xref="InterPro:IPR021153" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10662" /db_xref="UniProtKB/Swiss-Prot:P25499" /translation="MLTNRQLLILQVIINDFIKSAQPVGSRTLSKKDEITFSSATIRN EMADLEELGFIEKTHSSSGRVPSEKGYRYYVDHLLSPVKLTKSDLDQIHSIFKEKIFE LEKTVQKSAQILSDLTNYTSIVLGPKLSENYLKQIQIIPIQPDMAVAILVTNTGHVEN KTINFPTKMDLSDIEKLVNILNDRLSGVPMDELNERIFKEVVMYLRQHIKNYDNILDA LRSTFHSTNHVEKLFFGGKINMLNQPEFHDITRVRSLLSLIEKEQDVLKLVQSPHTGI SIKIGKENDYEEMENCSLITASYSVDQKQIGSIAIIGPTRMNYSRVVSLLQHVTSDLS KALTSLYDE*" /label="hrcA CDS" gene complement(2213371..2214402) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /label="hrcA gene" promotor_-10 complement(2214443..2214462) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2214456) /Source="Nicolas_upshifts" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2214477..2214484) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2214483..2215622) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /EC_number="1.3.98.3" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8757728, 9371469, 10498703, 12196143, 19944166" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8757728, 9371469, 10498703, 12196143, 19944166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_390428.2" /db_xref="EnsemblGenomes-Gn:BSU25500" /db_xref="EnsemblGenomes-Tr:CAB14492" /db_xref="GOA:P54304" /db_xref="InterPro:IPR004559" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010723" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG11395" /db_xref="UniProtKB/Swiss-Prot:P54304" /translation="MKSAYIHIPFCEHICHYCDFNKYFIQSQPVDEYLNALEQEMINT IAKTGQPDLKTIFIGGGTPTSLSEEQLKKLMDMINRVLKPSSDLSEFAVEANPDDLSA EKLKILKEAGVNRLSFGVQTFEDDLLEKIGRVHKQKDVFTSFERAREIGFENISLDLM FGLPGQTLKHLEHSINTALSLDAEHYSVYSLIVEPKTVFYNLMQKGRLHLPPQEQEAE MYEIVMSKMEAHGIHQYEISNFAKAGMESKHNLTYWSNEQYFGFGAGAHGYIGGTRTV NVGPVKHYIDLIAEKGFPYRDTHEVTTEEQIEEEMFLGLRKTAGVSKKRFAEKYGRSL DGLFPSVLKDLAEKGLIHNSESAVYLTHQGKLLGNEVFGAFLGEL*" /label="hemN CDS" gene complement(2214483..2215622) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /label="hemN gene" promotor_-10 complement(2215495..2215506) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-10" upshifts complement(2215499) /Source="Nicolas_upshifts" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="upshifts" promotor_-35 complement(2215520..2215526) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-35" CDS complement(2215675..2217513) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12511492, 17110332, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal elongation factor, GTPase" /protein_id="NP_390429.1" /db_xref="EnsemblGenomes-Gn:BSU25510" /db_xref="EnsemblGenomes-Tr:CAB14493" /db_xref="GOA:P37949" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006297" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR013842" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035654" /db_xref="SubtiList:BG10441" /db_xref="UniProtKB/Swiss-Prot:P37949" /translation="MTDKEKRLERQSRIRNFSIIAHIDHGKSTLADRILEKTSAITQR EMKEQLLDSMDLERERGITIKLNSVQLKYKAKDGEEYIFHLIDTPGHVDFTYEVSRSL AACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPSAEPERVRQEVEDV IGLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGDPEAPLKALIFDSLYDAYRGVVA YIRVVEGTVKPGQKIKMMATGKEFEVTEVGVFTPKATPTNELTVGDVGFLTASIKNVG DTRVGDTITSAANPAEEALPGYRKLNPMVYCGLYPIDTAKYNDLREALEKLELNDSSL QYEAETSQALGFGFRCGFLGMLHMEIIQERIEREFNIDLITTAPSVIYDVYMTDGEKV VVDNPSNMPDPQKIERVEEPYVKATMMVPNDYVGAVMELCQGKRGNFIDMQYLDANRV SIIYDMPLAEIVYEFFDQLKSSTKGYASFDYELIGYKPSKLVKMDIMLNGEKIDALSF IVHRDYAYERGKVIVEKLKELIPRQQFEVPVQAAIGQKIVARSTIKAMRKNVLAKCYG GDISRKRKLLEKQKEGKRRMKQVGSVEVPQEAFMAVLKMDDSPKKQ*" /label="lepA CDS" gene complement(2215675..2217513) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /label="lepA gene" downshifts complement(2215697) /Source="Nicolas_upshifts" /id="D1319" /incds=0 /nref=15 /ntot=213 /MaxReadThrough="5.2925" /MaxDrop="3.979" /score="5.45344919" /energy="-14" /TU="U1985" /idTUdmin="U1984" /TUdmin="-1232" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2217548..2217567) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2217565) /Source="Nicolas_upshifts" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2217583..2217587) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2217647..2217985) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390430.1" /db_xref="EnsemblGenomes-Gn:BSU25520" /db_xref="EnsemblGenomes-Tr:CAB14494" /db_xref="InterPro:IPR020534" /db_xref="SubtiList:BG10440" /db_xref="UniProtKB/Swiss-Prot:P38425" /translation="MIAYFGKCLLLVTIMFLGVLFGMQQANHGMLSMKGYHDPSLKGA FTLTDGKDNEKEASILGETVTAKDLVEKQKELEKVETFNMFSKAGKALSDTVTNTAQS MYEWIRDMNQ*" /label="yqxA CDS" gene complement(2217647..2217985) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /label="yqxA gene" downshifts complement(2217653) /Source="Nicolas_upshifts" /id="D1320" /incds=0 /nref=11 /ntot=43 /MaxReadThrough="2.553" /MaxDrop="3.8126" /score="5.45344919" /energy="-14" /TU="NA" /idTUdmin="U1986" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2218002..2219207) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17376078, 23834622" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17376078, 23834622; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore autolysin (stage II sporulation)" /protein_id="NP_390431.1" /db_xref="EnsemblGenomes-Gn:BSU25530" /db_xref="EnsemblGenomes-Tr:CAB14495" /db_xref="GOA:P37968" /db_xref="InterPro:IPR010897" /db_xref="SubtiList:BG10439" /db_xref="UniProtKB/Swiss-Prot:P37968" /translation="MRNKRRNRQIVVAVNGGKAVKAIFLFIVSLIVIFVLSGVLTSLR PELRPSSDSFYGIAEELPGDVFAHLLQMENHYFASDLSQTDSSFHLSRLSLKLATSIN LEDPRSFLGRELPGFAQFDTEILLAGQGTDYTNMPAESPPPSKVMEEEREANLAEIEK QQTQSDNAQKDPPKQTTGDKKVVFIYHTHNTESYLPLLKGETDPDMARHSKANVTLVG DMFGQALESQGIGATVNKTDIQSKLNKKGLNYARSYDESRPVVKDALASNKNLQYIID IHRDSRRKKDTTATIKGKSYARVAFVVGKKSKNFEENYKIASELHKLMEKKYPGLSTG VFSKGSPGDNGVYNQDLTDRALLLEFGGVDNNLEELQRAANAAADVFSEMYWDAEKVN AASGETKKQ*" /label="spoIIP CDS" gene complement(2218002..2219207) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /label="spoIIP gene" promotor_-10 complement(2219227..2219245) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2219239) /Source="Nicolas_upshifts" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2219261..2219266) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2219270..2220376) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /EC_number="3.4.24.78" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10666631, 10986255, 12807468, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666631, 10986255, 12807468, 23927687; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protease" /protein_id="NP_390432.1" /db_xref="EnsemblGenomes-Gn:BSU25540" /db_xref="EnsemblGenomes-Tr:CAB14496" /db_xref="GOA:P22322" /db_xref="InterPro:IPR005080" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10438" /db_xref="UniProtKB/Swiss-Prot:P22322" /translation="MKKSELDVNQYLIRTDLAVETKEAMANQQAVPTKEIKGFIEKER DHGGIKIRTVDVTKEGAELSGKKEGRYLTLEAQGIRENDSEMQEKVSAVFAEEFSAFL ENLNISKDASCLIVGLGNWNVTPDALGPMAVENLLVTRHLFKLQPENVQEGYRPVSAF APGVMGITGIETSDIIKGVIEQSKPDFVIAIDALAARAVERVNTTIQISDTGIHPGSG VGNKRKDLSKDTLGVPVIAIGVPTVVDAVTIASDTVDYILKHFGREMKDNRPSRSLVP AGMTFGKKKVLTEDDLPDQKQRQSFLGIVGTLQEDEKRQLIHEVLSPLGHNLMVTPKE VDSFIDDMANVLANGLNTALHEKVSQENKGSYNH*" /label="gpr CDS" gene complement(2219270..2220376) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /label="gpr gene" promotor_-10 complement(2220404..2220415) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2220411) /Source="Nicolas_upshifts" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2220430..2220436) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2220475..2220478 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2220491 /Source="Nicolas_upshifts" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2220494..2220513 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2220505..2220579 /Source="Nicolas_S_feature" /locus_tag="new_2635740_2635814" /HighExp="HiTm, LPhT, UNK1, HiOs, dia5, aero, MG 15, SMM, Lbtran, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S961" CDS 2220580..2220846 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16629673, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16629673, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S20 (BS20)" /protein_id="NP_390433.2" /db_xref="EnsemblGenomes-Gn:BSU25550" /db_xref="EnsemblGenomes-Tr:CAB14497" /db_xref="GOA:P21477" /db_xref="InterPro:IPR002583" /db_xref="InterPro:IPR036510" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11643" /db_xref="UniProtKB/Swiss-Prot:P21477" /translation="MPNIKSAIKRTKTNNERRVHNATIKSAMRTAIKQVEASVANNEA DKAKTALTEAAKRIDKAVKTGLVHKNTAARYKSRLAKKVNGLSA*" /label="rpsT CDS" gene 2220580..2220846 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /label="rpsT gene" downshifts 2220835 /Source="Nicolas_upshifts" /id="D1321" /incds=0 /nref=244 /ntot=274 /MaxReadThrough="2.22204" /MaxDrop="8.54705" /score="33.3621187" /energy="-12.3" /TU="NA" /idTUdmin="U1988" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2220861..2221904) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9434186, 11432857, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9434186, 11432857, 12060778, 12682299, 22333191, 23525462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase clamp loader delta subunit" /protein_id="NP_390434.1" /db_xref="EnsemblGenomes-Gn:BSU25560" /db_xref="EnsemblGenomes-Tr:CAB14498" /db_xref="GOA:P54459" /db_xref="InterPro:IPR005790" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR010372" /db_xref="InterPro:IPR027417" /db_xref="PDB:3ZH9" /db_xref="SubtiList:BG11642" /db_xref="UniProtKB/Swiss-Prot:P54459" /translation="MVFDVWKSLKKGEVHPVYCLYGKETYLLQETVSRIRQTVVDQET KDFNLSVFDLEEDPLDQAIADAETFPFMGERRLVIVKNPYFLTGEKKKEKIEHNVSAL ESYIQSPAPYTVFVLLAPYEKLDERKKLTKALKKHAFMMEAKELNAKETTDFTVNLAK TEQKTIGTEAAEHLVLLVNGHLSSIFQEIQKLCTFIGDREEITLDDVKMLVARSLEQN IFELINKIVNRKRTESLQIFYDLLKQNEEPIKIMALISNQFRLILQTKYFAEQGYGQK QIASNLKVHPFRVKLAMDQARLFSEEELRLIIEQLAVMDYEMKTGKKDKQLLLELFLL QLLKRNEKNDPHY*" /label="holA CDS" gene complement(2220861..2221904) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /label="holA gene" downshifts complement(2220906) /Source="Nicolas_upshifts" /id="D1322" /incds=0 /nref=14 /ntot=198 /MaxReadThrough="1.76478" /MaxDrop="4.34213" /score="-1.12561483" /energy="-8.1" /TU="NA" /idTUdmin="U1989" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2221933..2221952) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2221944..2222093) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513978.1" /translation="MKNLEAKVTFSVLVIIAFLQAVPGACEQAFNINGEAAVRLPLYY FANSI*" /label="hypothetical protein CDS" gene complement(2221944..2222093) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /label="gene" upshifts complement(2221945) /Source="Nicolas_upshifts" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2221966..2221970) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2221968..2222307) /Source="Nicolas_S_feature" /locus_tag="new_2637203_2637542_c" /HighExp="S8, S6, S7, BT, S5, C30, Pyr, G/S, B36, GM 150" /AntisenseName="yqzM" /AntisenseCor="-2.0369593011890001E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S962" downshifts complement(2222011) /Source="Nicolas_upshifts" /id="D1323" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="5.04584" /MaxDrop="3.298" /score="-1.12561483" /energy="-8.1" /TU="U1991,U1995" /idTUdmin="U1992" /TUdmin=748 /isTUend="FALSE" /label="downshifts" promotor_-35 2222080..2222086 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2222100..2222119 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2222101 /Source="Nicolas_upshifts" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="upshifts" CDS 2222134..2222268 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097762.1" /db_xref="EnsemblGenomes-Gn:BSU25569" /db_xref="EnsemblGenomes-Tr:CAX52662" /db_xref="GOA:C0H453" /db_xref="InterPro:IPR025416" /db_xref="UniProtKB/Swiss-Prot:C0H453" /translation="MNDFEKNVQSKRNDAVDSAVGFVVSFGFFAFLFVMATVIHLVGS *" /label="yqzM CDS" gene 2222134..2222268 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /label="yqzM gene" downshifts 2222262 /Source="Nicolas_upshifts" /id="D1324" /incds=0 /nref=156 /ntot=250 /MaxReadThrough="3.51266" /MaxDrop="6.2258" /score="20.1810918" /energy="-12.1" /TU="U1990" /idTUdmin="U1990" /TUdmin="-465" /isTUend="FALSE" /label="downshifts" CDS complement(2222308..2224638) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12123453, 15661011, 16751195, 17630974, 21397556, 27318187" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123453, 15661011, 16751195, 17630974, 21397556, 27318187; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="DNA channel for uptake in competent cells" /protein_id="NP_390435.1" /db_xref="EnsemblGenomes-Gn:BSU25570" /db_xref="EnsemblGenomes-Tr:CAB14499" /db_xref="GOA:P39695" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004477" /db_xref="InterPro:IPR004797" /db_xref="InterPro:IPR025405" /db_xref="InterPro:IPR035681" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10482" /db_xref="UniProtKB/Swiss-Prot:P39695" /translation="MRNSRLLLPMAAASATAGITAAAYFPAIFLFILFLLIILIKTRH AFLIIVCFFSFILFFVLYAVTDSQNVSSYRQGTYQFKAVIDTIPKIDGDRMSMMVETP DKEKWAAAYRIQSAGEKEQLLYIEPGMSCELTGTLEEPNHATVPGAFDYNEYLYRQHI HWNYSVTSIQNCSEPENFKYKVLSLRKHIISFTNSLLPPDSTGIVQALTVGDRFYVED EVLTAYQKLGVVHLLAISGLHVGILTAGLFYIMIRLGITREKASILLLLFLPLYVMLT GAAPSVLRAALMSGVYLAGSLVKWRVRSATAICLSYIVLLLFNPYHLFEAGFQLSFAV SFSLILSSSIFQQVKTSLGQLTIVSLIAQLGSLPILLYHFHQFSIISVPMNMLMVPFY TFCILPGAVAGVLLLSLSASFGRLFFSWFDLLISWINRLITNIADVDVFTIMIAHPAP VLLFLFTVTIILLLMAIEKRSLSQLMVTGGICCTVMFLLFIYPCLSSEGEVDMIDIGQ GDSMFVGAPHQRGRVLIDTGGTLSYSSEPWREKQHPFSLGEKVLIPFLTAKGIKQLDA LILTHADQDHIGEAEILLKHHKVKRLVIPKGFVSEPKDEKVLQAAREEGVAIEEVKRG DVLQIKDLQFHVLSPEAPDPASKNNSSLVLWMETGGMSWILTGDLEKEGEQEVMNVFP NIKADVLKVGHHGSKGSTGEEFIQQLQPKTAIISAGKNNRYHHPHQKVLQLLQRHSIR VLRTDQNGTIQYRYKNRVGTFSVYPPYDTSDITETN*" /label="comEC CDS" gene complement(2222308..2224638) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /label="comEC gene" promotor_-10 complement(2222325..2222344) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2222341) /Source="Nicolas_upshifts" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2222358..2222367) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2224642..2225211) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /EC_number="3.5.4.12" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7768800, 26416910; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="dCMP deaminase associated to DNA transport (competence)" /protein_id="NP_390436.1" /db_xref="EnsemblGenomes-Gn:BSU25580" /db_xref="EnsemblGenomes-Tr:CAB14500" /db_xref="GOA:P32393" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR013404" /db_xref="InterPro:IPR015517" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR016473" /db_xref="InterPro:IPR035105" /db_xref="SubtiList:BG10481" /db_xref="UniProtKB/Swiss-Prot:P32393" /translation="MERISWNQYFMAQSHLLALRSTCPRLSVGATIVRDKRMIAGGYN GSIAGGVHCADEGCLMIDDHCARTIHAEMNAILQCSKFGVPTDGAEIYVTHYPCIQCC KSIIQAGIKTVYYAEDYKTHPYAQELFEQAGVTVEQVELDEMIVDLKNREKLSFVAGL IGKLADAGLAEEELKKIHEQANTLFTSYV*" /label="comEB CDS" gene complement(2224642..2225211) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /label="comEB gene" promotor_-10 complement(2225238..2225257) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2225248) /Source="Nicolas_upshifts" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2225272..2225279) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2225278..2225895) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16751195, 21278288, 22398145, 25727469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751195, 21278288, 22398145, 25727469; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane bound high-affinity DNA-binding receptor" /protein_id="NP_390437.1" /db_xref="EnsemblGenomes-Gn:BSU25590" /db_xref="EnsemblGenomes-Tr:CAB14501" /db_xref="GOA:P39694" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004509" /db_xref="InterPro:IPR004787" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR019554" /db_xref="SubtiList:BG10480" /db_xref="UniProtKB/Swiss-Prot:P39694" /translation="MNWLNQHKKAIILAASAAVFTAIMIFLATGKNKEPVKQAVPTET ENTVVKQEANNDESNETIVIDIKGAVQHPGVYEMRTGDRVSQAIEKAGGTSEQADEAQ VNLAEILQDGTVVYIPKKGEETAVQQGGGGSVQSDGGKGALVNINTATLEELQGISGV GPSKAEAIIAYREENGRFQTIEDITKVSGIGEKSFEKIKSSITVK*" /label="comEA CDS" gene complement(2225278..2225895) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /label="comEA gene" promotor_-35 2225916..2225921 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2225933 /Source="Nicolas_upshifts" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2225937..2225955 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2225956..2225970) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2225958) /Source="Nicolas_upshifts" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2225960..2226807) /Source="Nicolas_S_feature" /locus_tag="new_2641195_2642042_c" /HighExp="C30, T0.30H, T-2.40H, GM 150, T1.30H, T-0.40H, T-1.10H, T-1.40H, T1.0H, T0.0H" /AntisenseName="comER" /AntisenseCor="-8.2389039371154299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S963" promotor_-35 complement(2225979..2225983) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2225979..2226800 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /EC_number="1.5.1.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7968523, 11418582, 27446060, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrroline-5'-carboxylate reductase" /protein_id="NP_390438.1" /db_xref="EnsemblGenomes-Gn:BSU25600" /db_xref="EnsemblGenomes-Tr:CAB14502" /db_xref="GOA:P39696" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10479" /db_xref="UniProtKB/Swiss-Prot:P39696" /translation="MKIGFIGTGNMGTILIESFIESKAADPSNMTITNRTIEKALHIK NRYNSINVTESLEKLVSENEMIFICVKPLDIYPLLARALPYLRKDHILISITSPVQTE QLEQYVPCQVARVIPSITNRALAGVSLVTFGTSCGESAKAKINELMQHISHPLQIESD ITRVASDIVSCGPAFMSYLIQRFIDAAVSETSVSKQDAILMCKEMLVGMGKLLETELY TLPALQEKVCVKGGVTGEGIKALESGVQDMFHRVFQNTHMKYEEDISAVKKQFHV*" /label="comER CDS" gene 2225979..2226800 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /label="comER gene" promotor_-10 complement(2226795..2226814) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2226801..2226881 /Source="Nicolas_S_feature" /locus_tag="new_2642036_2642116" /HighExp="S4, S5, S3, S6, S7, B36, Pyr, G/S, S8, BT" /AntisenseName="yqeM" /AntisenseCor="-0.52267300854840604" /AntisenseRegPval="-19.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S964" upshifts complement(2226808) /Source="Nicolas_upshifts" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2226828..2226835) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2226841 /Source="Nicolas_upshifts" /id="D1325" /incds=0 /nref=45 /ntot=64 /MaxReadThrough="2.4803" /MaxDrop="5.1403" /score="7.09525061" /energy="-10.5" /TU="NA" /idTUdmin="U1993" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2226866..2227609) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390439.1" /db_xref="EnsemblGenomes-Gn:BSU25610" /db_xref="EnsemblGenomes-Tr:CAB14503" /db_xref="GOA:P54458" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11641" /db_xref="UniProtKB/Swiss-Prot:P54458" /translation="MIYQGFASVYDELMSHAPYDQWTKWIEASLPEKGRILDLACGTG EISIRLAEKGFEVTGIDLSEEMLSFAQQKVSSSQPILFLQQDMREITGFDGQFDAVVI CCDSLNYLKTKNDVIETFKSVFRVLKPEGILLFDVHSSFKIAEVFPDSTFADQDEDIS YIWQSFAGSDELSVIHDMSFFVWNGEAYDRFDETHEQRTFPVEEYEEMLKNCGFQLHR VTADFTDTEPSAQSERLFFKAQKSKTIVS*" /label="yqeM CDS" gene complement(2226866..2227609) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /label="yqeM gene" downshifts complement(2226896) /Source="Nicolas_upshifts" /id="D1326" /incds=0 /nref=144 /ntot=230 /MaxReadThrough="1.41467" /MaxDrop="5.51802" /score="7.9251293" /energy="-10.5" /TU="NA" /idTUdmin="U1996" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2227606..2227962) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 16980477, 22238375, 22238376, 22829778, 26299947; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal silencing factor" /protein_id="NP_390440.1" /db_xref="EnsemblGenomes-Gn:BSU25620" /db_xref="EnsemblGenomes-Tr:CAB14504" /db_xref="GOA:P54457" /db_xref="InterPro:IPR004394" /db_xref="SubtiList:BG11640" /db_xref="UniProtKB/Swiss-Prot:P54457" /translation="MNQKSILKIAAAACDDKRAEDILALDMEGISLVADYFLICHGNS DKQVQAIAREIKDQADENGIQVKKMEGFDEARWVLVDLGDVVVHVFHKDERSYYNLEK LWGDAPLADLDFGMNQ*" /label="rsfS CDS" gene complement(2227606..2227962) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /label="rsfS gene" CDS complement(2227980..2228540) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390441.1" /db_xref="EnsemblGenomes-Gn:BSU25630" /db_xref="EnsemblGenomes-Tr:CAB14505" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR005249" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11639" /db_xref="UniProtKB/Swiss-Prot:P54456" /translation="MNREEALACVKQQLTEHRYIHTVGVMNTAIELAERFGADSKKAE IAAIFHDYAKFRPKEEMKQIIAREKMPAHLLDHNPELWHAPVGAYLVQREAGVQDEDI LDAIRYHTSGRPGMTLLEKVIYVADYIEPNRAFPGVDEVRKLAETDLNQALIQSIKNT MVFLMKKNQPVFPDTFLTYNWLVSGS*" /label="yqeK CDS" gene complement(2227980..2228540) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /label="yqeK gene" CDS complement(2228530..2229099) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /EC_number="2.7.7.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11704676, 12682299, 19716475, 23204464, 25631047; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide adenylyltransferase" /protein_id="NP_390442.1" /db_xref="EnsemblGenomes-Gn:BSU25640" /db_xref="EnsemblGenomes-Tr:CAB14506" /db_xref="GOA:P54455" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR005248" /db_xref="InterPro:IPR014729" /db_xref="PDB:1KAM" /db_xref="PDB:1KAQ" /db_xref="SubtiList:BG11638" /db_xref="UniProtKB/Swiss-Prot:P54455" /translation="MKKIGIFGGTFDPPHNGHLLMANEVLYQAGLDEIWFMPNQIPPH KQNEDYTDSFHRVEMLKLAIQSNPSFKLELVEMEREGPSYTFDTVSLLKQRYPNDQLF FIIGADMIEYLPKWYKLDELLNLIQFIGVKRPGFHVETPYPLLFADVPEFEVSSTMIR ERFKSKKPTDYLIPDKVKKYVEENGLYES*" /label="nadD CDS" gene complement(2228530..2229099) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /label="nadD gene" CDS complement(2229111..2229401) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 17005971, 17105995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 17005971, 17105995; Product type f: factor" /codon_start=1 /transl_table=11 /product="50S RNA-binding protein" /protein_id="NP_390443.1" /db_xref="EnsemblGenomes-Gn:BSU25650" /db_xref="EnsemblGenomes-Tr:CAB14507" /db_xref="GOA:P54454" /db_xref="InterPro:IPR001890" /db_xref="InterPro:IPR017924" /db_xref="InterPro:IPR035920" /db_xref="SubtiList:BG11637" /db_xref="UniProtKB/Swiss-Prot:P54454" /translation="MLTGKQKRFLRSKAHHLTPIFQVGKGGVNDNMIKQIAEALEARE LIKVSVLQNCEEDKNDVAEALVKGSRSQLVQTIGNTIVLYKESKENKQIELP*" /label="yqeI CDS" gene complement(2229111..2229401) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /label="yqeI gene" CDS complement(2229395..2230237) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /EC_number="1.1.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2104604, 12906820, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate 5-dehydrogenase" /protein_id="NP_390444.2" /db_xref="EnsemblGenomes-Gn:BSU25660" /db_xref="EnsemblGenomes-Tr:CAB14508" /db_xref="GOA:P54374" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR011342" /db_xref="InterPro:IPR013708" /db_xref="InterPro:IPR022893" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11522" /db_xref="UniProtKB/Swiss-Prot:P54374" /translation="MKKLYGVIGNPIGHSMSPDIHNASLKDLGLDGHYHAFKVEENDL EDAVKGIRALGVQGINVTVPHKVSIMDYLDHIDESAKVLGAVNTVRREGDKLVGYNTD GEGFVKSLMKVLDKPISELSFLMIGAGGAARAIFTTIVRNTPKKFDICNRTLEKAKRL TEATPSFHNKEVLSIKEAEERLEQYDVIIHTTSVGMYPNVDDVPLSLQRAASSAVVCD IVYNPIQTALLKEASQKGLKTLDGVGMFVEQAALSFQLWTGQEPNIEKMRSIVIGKLG GTEC*" /label="aroE CDS" gene complement(2229395..2230237) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /label="aroE gene" downshifts 2230229 /Source="Nicolas_upshifts" /id="D1327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="0.240279999999999" /MaxDrop="3.04009" /score="0.0642154872" /energy="-17" /TU="NA" /idTUdmin="U1993" /TUdmin=3388 /isTUend="FALSE" /label="downshifts" CDS complement(2230255..2231355) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent GTPase involved in ribosome 30S assembly" /protein_id="NP_390445.1" /db_xref="EnsemblGenomes-Gn:BSU25670" /db_xref="EnsemblGenomes-Tr:CAB14509" /db_xref="GOA:P54453" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019988" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="SubtiList:BG11636" /db_xref="UniProtKB/Swiss-Prot:P54453" /translation="MEKVVCIGCGVTIQTEDKTGLGYAPPASLTKENVICQRCFRLKN YNEIQDVSLTDDDFLNILHGIGETDSLVVKIVDIFDFNGSWINGLQRLVGGNPILLVG NKADILPKSLKRERLIQWMKREAKELGLKPVDVFLVSAGRGQGIREVIDAIEHYRNGK DVYVVGCTNVGKSTFINRIIKEVSGEEDIITTSQFPGTTLDAIEIPLDDGSSLYDTPG IINNHQMAHYVNKKDLKILSPKKELKPRTFQLNDQQTLYFGGLARFDYVSGERSPFIC YMPNELMIHRTKLENADALYEKHAGELLTPPGKDEMDEFPELVAHTFTIKDKKTDIVF SGLGWVTVHDADKKVTAYAPKGVHVFVRRSLI*" /label="rgpH CDS" gene complement(2230255..2231355) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /label="rgpH gene" CDS complement(2231359..2231877) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase (active on GMP and Glc-6-P)" /protein_id="NP_390446.1" /db_xref="EnsemblGenomes-Gn:BSU25680" /db_xref="EnsemblGenomes-Tr:CAB14510" /db_xref="GOA:P54452" /db_xref="InterPro:IPR006356" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR006549" /db_xref="InterPro:IPR010021" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11635" /db_xref="UniProtKB/Swiss-Prot:P54452" /translation="MLKKFFLPDEFVKNIFHITPEKLKERNVKGIITDLDNTLVEWDR PNATPRLIEWFEEMKEHGIKVTIVSNNNERRVKLFSEPLGIPFIYKARKPMGKAFNRA VRNMELKKEDCVVIGDQLLTDVLGGNRNGYHTILVVPVASSDGFITRFNRQVERRILS ALKRKGHIQWEE*" /label="yqeG CDS" gene complement(2231359..2231877) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /label="yqeG gene" promotor_-10 complement(2231787..2231804) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2231801) /Source="Nicolas_upshifts" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2231820..2231823) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2231878..2232439) /Source="Nicolas_S_feature" /locus_tag="new_2647113_2647674_c" /HighExp="G135, G180, G150, Paraq, Oxctl, C30, Heat, HPh, BMM, LPh" /AntisenseName="sda" /AntisenseCor="-8.6107693225382295E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S965" downshifts complement(2231911) /Source="Nicolas_upshifts" /id="D1328" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="6.83118" /MaxDrop="5.26138" /score="9.20556883" /energy="-8.6" /TU="U1998" /idTUdmin="U1999" /TUdmin=616 /isTUend="FALSE" /label="downshifts" promotor_-35 2232102..2232109 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2232120..2232220 /Source="Nicolas_S_feature" /locus_tag="new_2647355_2647455" /HighExp="T3.0H, T-0.40H, MG 150, T5.0H, T-1.40H, T4.0H, T2.30H, T0.0H, T3.30H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S966" promotor_-10 2232120..2232139 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2232120 /Source="Nicolas_upshifts" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(2232170..2232428) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /product="antisense RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="sdaM RNA" gene complement(2232170..2232428) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /label="sdaM gene" CDS 2232221..2232379 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15023339, 16796683, 19040634, 22720735, 28752667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15023339, 16796683, 19040634, 22720735, 28752667; Product type f: factor" /codon_start=1 /transl_table=11 /product="check point factor coupling initiation of sporulation and replication initiation" /protein_id="YP_054588.1" /db_xref="EnsemblGenomes-Gn:BSU25690" /db_xref="EnsemblGenomes-Tr:CAE01463" /db_xref="GOA:Q7WY62" /db_xref="InterPro:IPR015064" /db_xref="InterPro:IPR036916" /db_xref="PDB:1PV0" /db_xref="PDB:3FYR" /db_xref="SubtiList:BG14183" /db_xref="UniProtKB/Swiss-Prot:Q7WY62" /translation="MNWVPSMRKLSDELLIESYFKATEMNLNRDFIELIENEIKRRSL GHIISVSS*" /label="sda CDS" gene 2232221..2232379 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /label="sda gene" S_feature 2232380..2232626 /Source="Nicolas_S_feature" /locus_tag="new_2647615_2647861" /HighExp="Cold, T-0.40H, MG 150, T5.0H, T4.0H, C30, T2.30H, M9-tran, S2, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S967" promotor_-10 complement(2232427..2232446) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2232438) /Source="Nicolas_upshifts" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2232462..2232466) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2232490..2232637) /Source="Nicolas_S_feature" /locus_tag="new_2647725_2647872_c" /HighExp="S8, S7, S6, Etha, LBGstat, T0.30H, Salt, BT, LPhT, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99948400000000004" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S968" downshifts complement(2232527) /Source="Nicolas_upshifts" /id="D1329" /incds=0 /nref=12 /ntot=92 /MaxReadThrough="2.70676" /MaxDrop="4.386" /score="9.20556883" /energy="-8.6" /TU="NA" /idTUdmin="U1999" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2232583 /Source="Nicolas_upshifts" /id="D1330" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="5.36291" /MaxDrop="2.1106" /score="10.3636587" /energy="-6.2" /TU="U1997" /idTUdmin="U1997" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" S_feature 2232628..2233681 /Source="Nicolas_S_feature" /locus_tag="new_2647863_2648916" /HighExp="T-0.40H, Cold, M40t90, T0.0H, C30, Glucon, S2, T1.30H, T2.30H, T2.0H" /AntisenseName="yqeF" /AntisenseCor="-0.39616310996746001" /AntisenseRegPval="-10.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S969" promotor_-10 complement(2232632..2232651) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2232637) /Source="Nicolas_upshifts" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2232664..2232673) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2232685..2233416) /gene="yqeF" /locus_tag="BSU_25700" /old_locus_tag="BSU25700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipoprotein; putative esterase" /protein_id="NP_390447.1" /db_xref="EnsemblGenomes-Gn:BSU25700" /db_xref="EnsemblGenomes-Tr:CAB14511" /db_xref="GOA:P54451" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11634" /db_xref="UniProtKB/Swiss-Prot:P54451" /translation="MKHFIILFLLLFVTAGCEGRGYEDVVAFGDSNTRGSNWDYRDYP KAQQWVNILKTAERGNLDILNAGIGGQTTEDARLRFQTDVLDQKPKYLFIMFGTNDAA ILTEGKPRVSKQRFRENLVYFIEESRKHGIKPILMTCIPIIEGNGKHHLFYYSRYQAA AFEPKGGARKWHNSYNDITRDVSKRLDVPLVDNWKHFIEADGGKATDEALIQSGLIDP SGNHMTPKGARIVYEGIQDGQILQR*" /label="yqeF CDS" gene complement(2232685..2233416) /gene="yqeF" /locus_tag="BSU_25700" /old_locus_tag="BSU25700" /label="yqeF gene" promotor_-10 complement(2233435..2233454) /Source="Nicolas_upshift_promotors" /id="U2000" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.380619380619381" /psig=1 /xcortree=2739 /SigmaFactorBS="taactataggaaaaaacagtgatagcgaaaaactcttCATTG AAcgaagagaaacagAGGTATAACATTAAAGTGAGgcttttgggggtgtaaagatgaa a" /listShort="yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2233451) /Source="Nicolas_upshifts" /id="U2000" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.380619380619381" /psig=1 /xcortree=2739 /SigmaFactorBS="taactataggaaaaaacagtgatagcgaaaaactcttCATTG AAcgaagagaaacagAGGTATAACATTAAAGTGAGgcttttgggggtgtaaagatgaa a" /listShort="yqeF, S968" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2233453..2233561) /Source="Nicolas_S_feature" /locus_tag="new_2648688_2648796_c" /HighExp="Etha, Salt, Gly, S8, C30, S7, LPhT, Sw, Heat, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S970" promotor_-35 complement(2233468..2233474) /Source="Nicolas_upshift_promotors" /id="U2000" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.380619380619381" /psig=1 /xcortree=2739 /SigmaFactorBS="taactataggaaaaaacagtgatagcgaaaaactcttCATTG AAcgaagagaaacagAGGTATAACATTAAAGTGAGgcttttgggggtgtaaagatgaa a" /listShort="yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2233562..2233580) /Source="Nicolas_upshift_promotors" /id="U2001" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=162 /SigmaFactorBS="tttccagtgcggattcaggttattttcttttctttggtttgt gTGTTTTtcagattggaaagaAGGGAATTTTAAAAAATCAtcagctgcgccgcaatga a" /listShort="S970, yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2233583) /Source="Nicolas_upshifts" /id="U2001" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=162 /SigmaFactorBS="tttccagtgcggattcaggttattttcttttctttggtttgt gTGTTTTtcagattggaaagaAGGGAATTTTAAAAAATCAtcagctgcgccgcaatga a" /listShort="S970, yqeF, S968" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2233595..2233600) /Source="Nicolas_upshift_promotors" /id="U2001" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=162 /SigmaFactorBS="tttccagtgcggattcaggttattttcttttctttggtttgt gTGTTTTtcagattggaaagaAGGGAATTTTAAAAAATCAtcagctgcgccgcaatga a" /listShort="S970, yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2233668..2234420) /gene="cwlH" /locus_tag="BSU_25710" /old_locus_tag="BSU25710" /EC_number="3.5.1.28" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10515909, 10974124, 15687192" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10515909, 10974124, 15687192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_390448.1" /db_xref="EnsemblGenomes-Gn:BSU25710" /db_xref="EnsemblGenomes-Tr:CAB14512" /db_xref="GOA:P54450" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR002502" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="InterPro:IPR036505" /db_xref="SubtiList:BG11633" /db_xref="UniProtKB/Swiss-Prot:P54450" /translation="MVTIKKDFIPVSNDNRPGYAMAPAYITVHNTANTAKGADAKMHA KFVKNPNTSESWHFTVDDSVIYQHLPIDENGWHAGDGTNGTGNRKSIGIEICENADGD FEKATSNAQWLIRKLMKENNIPLNRVVPHKKWSGKECPRKLLDHWNSFLNGISSSDTP PKETSPSYPLPSGVIKLTSPYRKGTNILQLQKALAVLHFYPDKGAKNNGIDGVYGPKT ANAVKRFQLMNGLTADGIYGPKTKAKLKSKLK*" /label="cwlH CDS" gene complement(2233668..2234420) /gene="cwlH" /locus_tag="BSU_25710" /old_locus_tag="BSU25710" /label="cwlH gene" downshifts complement(2233671) /Source="Nicolas_upshifts" /id="D1331" /incds=0 /nref=4 /ntot=10 /MaxReadThrough="1.29819" /MaxDrop="4.65121" /score="4.6304411" /energy="-10.7" /TU="NA" /idTUdmin="U2003" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2233799..2233805 /Source="Nicolas_upshift_promotors" /id="U2002" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=171 /SigmaFactorBS="ctgttttcggtccgtaaactccatctatgccatTGTTTTTgg ctcccttatcaGGGTAAAAGTGAAGTACAGctaaagccttttgcagctggagaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2233819..2233837 /Source="Nicolas_upshift_promotors" /id="U2002" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=171 /SigmaFactorBS="ctgttttcggtccgtaaactccatctatgccatTGTTTTTgg ctcccttatcaGGGTAAAAGTGAAGTACAGctaaagccttttgcagctggagaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2233826 /Source="Nicolas_upshifts" /id="U2002" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=171 /SigmaFactorBS="ctgttttcggtccgtaaactccatctatgccatTGTTTTTgg ctcccttatcaGGGTAAAAGTGAAGTACAGctaaagccttttgcagctggagaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2234430..2234449) /Source="Nicolas_upshift_promotors" /id="U2003" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.898101898101898" /psig="0.898101898101898" /xcortree=1426 /SigmaFactorBS="caggttaagaacacaattcttttttacctcataaaaaaGGCT GTCCAtctctctgttttcTGCATTCTTATTAATAGGGAgggatagaaatggtaaccat a" /listShort="cwlH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2234449) /Source="Nicolas_upshifts" /id="U2003" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.898101898101898" /psig="0.898101898101898" /xcortree=1426 /SigmaFactorBS="caggttaagaacacaattcttttttacctcataaaaaaGGCT GTCCAtctctctgttttcTGCATTCTTATTAATAGGGAgggatagaaatggtaaccat a" /listShort="cwlH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2234463..2234471) /Source="Nicolas_upshift_promotors" /id="U2003" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.898101898101898" /psig="0.898101898101898" /xcortree=1426 /SigmaFactorBS="caggttaagaacacaattcttttttacctcataaaaaaGGCT GTCCAtctctctgttttcTGCATTCTTATTAATAGGGAgggatagaaatggtaaccat a" /listShort="cwlH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2234515..2234522 /Source="Nicolas_upshift_promotors" /id="U2004" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1830 /SigmaFactorBS="aggtaaaaaagaattgtgttcttaacctggttttCAGTTGAA cagctgaaatggcaCCAGTTATACTAATTTAGATgacggaggttttgactcctgacat c" /listShort="S971, yqeD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2234537..2234556 /Source="Nicolas_upshift_promotors" /id="U2004" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1830 /SigmaFactorBS="aggtaaaaaagaattgtgttcttaacctggttttCAGTTGAA cagctgaaatggcaCCAGTTATACTAATTTAGATgacggaggttttgactcctgacat c" /listShort="S971, yqeD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2234541..2234606 /Source="Nicolas_S_feature" /locus_tag="new_2649776_2649841" /HighExp="dia15, H2O2, C30, G180, Heat, S8, Paraq, Oxctl, LBGexp, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S971" upshifts 2234541 /Source="Nicolas_upshifts" /id="U2004" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1830 /SigmaFactorBS="aggtaaaaaagaattgtgttcttaacctggttttCAGTTGAA cagctgaaatggcaCCAGTTATACTAATTTAGATgacggaggttttgactcctgacat c" /listShort="S971, yqeD" /GFF_Attribute="listLong" /label="upshifts" CDS 2234607..2235233 /gene="yqeD" /locus_tag="BSU_25720" /old_locus_tag="BSU25720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 15855514, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390449.1" /db_xref="EnsemblGenomes-Gn:BSU25720" /db_xref="EnsemblGenomes-Tr:CAB14513" /db_xref="GOA:P54449" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG11632" /db_xref="UniProtKB/Swiss-Prot:P54449" /translation="MLKKVIGILVIIAIISVGFFQKEAWLDAIKAGGMFSVLFSMLLI AADVFFPIVPFALIAALNGAVFGTANGIWITLTGSMLGTILLFFLARYSFRDWARKKV QAYPAIQSYEASFNKNAFTAVLLGRLIPVIPSLVMNVICGLSQVRWHVFFFASLIGKI PNIVVVTIAGANFTSNKLLSISIYGTYILIIMLVIYKKFPHLLKVPKK*" /label="yqeD CDS" gene 2234607..2235233 /gene="yqeD" /locus_tag="BSU_25720" /old_locus_tag="BSU25720" /label="yqeD gene" downshifts 2235201 /Source="Nicolas_upshifts" /id="D1332" /incds=0 /nref=2 /ntot=63 /MaxReadThrough="2.9326" /MaxDrop="2.91074" /score="15.7108141" /energy="-10.3" /TU="U2004" /idTUdmin="U2004" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2235252..2236145) /gene="yqeC" /locus_tag="BSU_25730" /old_locus_tag="BSU25730" /EC_number="1.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10658669, 15231785; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative catabolic 6-phospho-gluconate dehydrogenase (NAD[+]-dependent)" /protein_id="NP_390450.1" /db_xref="EnsemblGenomes-Gn:BSU25730" /db_xref="EnsemblGenomes-Tr:CAB14514" /db_xref="GOA:P54448" /db_xref="InterPro:IPR004849" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11631" /db_xref="UniProtKB/Swiss-Prot:P54448" /translation="MKIGLIGLGKMGINIGKQFIDRNHQVVGYDVNQAAVDELKAYGA EGTTNLKEFISLLHPPRILWVMVPHGIVDAVLRDVSPLLSKGDMIIEAGNSHYKESIR RYNQMKEAGIHYLDAGTSGGMEGARHGACFMVGGDHEAWEIVEPLFRDTAVENGYLYA GEAGSGHFLKMIHNGIEYGMMAAIGEGFEVLENSQFDFDYEKVARVWNHGSVIRSWLM GLTERAFAKDAKLDQIKGIMHSSGEGKWTVETALDLQTATPVIAMSLMMRYRSLTDDT FTGKVVAALRNEFGGHATEKK*" /label="yqeC CDS" gene complement(2235252..2236145) /gene="yqeC" /locus_tag="BSU_25730" /old_locus_tag="BSU25730" /label="yqeC gene" downshifts complement(2235277) /Source="Nicolas_upshifts" /id="D1333" /incds=0 /nref=4 /ntot=12 /MaxReadThrough="1.46947" /MaxDrop="3.03963" /score="0.698755756" /energy="-8.4" /TU="NA" /idTUdmin="U2003" /TUdmin="-1606" /isTUend="FALSE" /label="downshifts" promotor_-35 2236328..2236334 /Source="Nicolas_upshift_promotors" /id="U2005" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.874125874125874" /psig="0.998001998001998" /xcortree=3104 /SigmaFactorBS="tctattactgaatctctttatatccataattatcgctttatc CTTGATTtaccatcagttTAAGTTAAAATATGGGAAGGaattcgattttttcagtaaa a" /listShort="yqeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2236346..2236365 /Source="Nicolas_upshift_promotors" /id="U2005" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.874125874125874" /psig="0.998001998001998" /xcortree=3104 /SigmaFactorBS="tctattactgaatctctttatatccataattatcgctttatc CTTGATTtaccatcagttTAAGTTAAAATATGGGAAGGaattcgattttttcagtaaa a" /listShort="yqeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2236346 /Source="Nicolas_upshifts" /id="U2005" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.874125874125874" /psig="0.998001998001998" /xcortree=3104 /SigmaFactorBS="tctattactgaatctctttatatccataattatcgctttatc CTTGATTtaccatcagttTAAGTTAAAATATGGGAAGGaattcgattttttcagtaaa a" /listShort="yqeB" /GFF_Attribute="listLong" /label="upshifts" CDS 2236397..2237119 /gene="yqeB" /locus_tag="BSU_25740" /old_locus_tag="BSU25740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390451.2" /db_xref="EnsemblGenomes-Gn:BSU25740" /db_xref="EnsemblGenomes-Tr:CAB14515" /db_xref="GOA:P54447" /db_xref="SubtiList:BG11630" /db_xref="UniProtKB/Swiss-Prot:P54447" /translation="MLQNQSHTLIGVTKTAVFFLYAALAIIGFAIGYFIPQIAKWALS LPWIPLEGPLRLITSFQGSTASFITALLGMCAGIWFAHSVIAMLLSVKITDHTVEFIK GKKVQTIHSDDIALVFMDHKRLVLLGTAGYELVREEIDEKPVNVEKAFRQHHYEWATD GDPFKDQFRRWIPDAPDLSQGAHALLKARHKALQDEEKDDIEEFRLELAQLGIVVRDE GTRQYWRKAETYPPKIQLGEGL*" /label="yqeB CDS" gene 2236397..2237119 /gene="yqeB" /locus_tag="BSU_25740" /old_locus_tag="BSU25740" /label="yqeB gene" CDS complement(2237152..2237562) /gene="nucB" /locus_tag="BSU_25750" /old_locus_tag="BSU25750" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7746143, 17209033, 21179489" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746143, 17209033, 21179489; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation-specific matrix degrading exported DNase" /protein_id="NP_390452.1" /db_xref="EnsemblGenomes-Gn:BSU25750" /db_xref="EnsemblGenomes-Tr:CAB14516" /db_xref="GOA:P42983" /db_xref="InterPro:IPR029476" /db_xref="SubtiList:BG11237" /db_xref="UniProtKB/Swiss-Prot:P42983" /translation="MKKWMAGLFLAAAVLLCLMVPQQIQGASSYDKVLYFPLSRYPET GSHIRDAIAEGHPDICTIDRDGADKRREESLKGIPTKPGYDRDEWPMAVCEEGGAGAD VRYVTPSDNRGAGSWVGNQMSSYPDGTRVLFIVQ*" /label="nucB CDS" gene complement(2237152..2237562) /gene="nucB" /locus_tag="BSU_25750" /old_locus_tag="BSU25750" /label="nucB gene" downshifts complement(2237177) /Source="Nicolas_upshifts" /id="D1334" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="0.80212" /MaxDrop="3.40706" /score="-0.144589925" /energy="-9.3" /TU="NA" /idTUdmin="U2006" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2237582..2237600) /Source="Nicolas_upshift_promotors" /id="U2006" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1115 /SigmaFactorBS="cagcatactaacttcaaatgttaAAAATAttcttcatcaagc gcCCATACATTGAAATGAACAaaggtatggggggatggggatgaaaaaatggatggca g" /listShort="nucB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2237584) /Source="Nicolas_upshifts" /id="U2006" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1115 /SigmaFactorBS="cagcatactaacttcaaatgttaAAAATAttcttcatcaagc gcCCATACATTGAAATGAACAaaggtatggggggatggggatgaaaaaatggatggca g" /listShort="nucB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2237616..2237621) /Source="Nicolas_upshift_promotors" /id="U2006" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1115 /SigmaFactorBS="cagcatactaacttcaaatgttaAAAATAttcttcatcaagc gcCCATACATTGAAATGAACAaaggtatggggggatggggatgaaaaaatggatggca g" /listShort="nucB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2237685..2237693 /Source="Nicolas_upshift_promotors" /id="U2007" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1062 /SigmaFactorBS="ttaccaaagccggactcccccgcgagaaatttcccggtaCAG ACACAGacagcctcccggtCACATACATTTACATATAGGcttttgcctacatactttt g" /listShort="spoIVCB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2237706 /Source="Nicolas_upshifts" /id="U2007" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1062 /SigmaFactorBS="ttaccaaagccggactcccccgcgagaaatttcccggtaCAG ACACAGacagcctcccggtCACATACATTTACATATAGGcttttgcctacatactttt g" /listShort="spoIVCB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2237707..2237726 /Source="Nicolas_upshift_promotors" /id="U2007" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1062 /SigmaFactorBS="ttaccaaagccggactcccccgcgagaaatttcccggtaCAG ACACAGacagcctcccggtCACATACATTTACATATAGGcttttgcctacatactttt g" /listShort="spoIVCB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2237758..2238228 /gene="sigKn" /locus_tag="BSU_25760" /old_locus_tag="BSU25760" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8464402, 7704261, 2536191, 2163341, 10974124, 15187183, 20889742" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8464402, 7704261, 2536191, 2163341, 10974124, 15187183, 20889742; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma-K factor precursor (Sigma-27) (N-terminal half)" /db_xref="GOA:P12254" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="PSEUDO:CAB14517.2" /db_xref="SubtiList:BG10459" /db_xref="UniProtKB/Swiss-Prot:P12254" /translation="MVTGVFAALGFVVKELVFLVSYVKNNAFPQPLSSSEEKKYLELM AKGDEHARNMLIEHNLRLVAHIVKKFENTGEDAEDLISIGTIGLIKGIESYSAGKGTK LATYAARCIENEIVITKGGCIHPSLIRFNIYGVRIHNGNFFHDKVNNCFFIFKS*" /label="sigKn CDS" gene 2237758..2238228 /gene="sigKn" /locus_tag="BSU_25760" /old_locus_tag="BSU25760" /pseudo /label="sigKn gene" downshifts 2237948 /Source="Nicolas_upshifts" /id="D1335" /incds=1 /nref=2 /ntot=5 /MaxReadThrough="7.53734" /MaxDrop="3.01863" /score="-7.46047649" /energy="-12.1" /TU="U2007" /idTUdmin="U2007" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 2238080 /Source="Nicolas_upshifts" /id="D1336" /incds=1 /nref=44 /ntot=61 /MaxReadThrough="0.8049" /MaxDrop="7.21386" /score="-7.46047649" /energy="-12.1" /TU="NA" /idTUdmin="U2007" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2238136..2239638) /gene="spoIVCA" /locus_tag="BSU_25770" /old_locus_tag="BSU25770" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1631085, 2163341, 7704261, 8300549, 8969508, 8655528, 18673456" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1631085, 2163341, 7704261, 8300549, 8969508, 8655528, 18673456; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific DNA recombinase; skin element" /protein_id="NP_390454.2" /db_xref="EnsemblGenomes-Gn:BSU25770" /db_xref="EnsemblGenomes-Tr:CAB14518" /db_xref="GOA:P17867" /db_xref="InterPro:IPR006118" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR011109" /db_xref="InterPro:IPR025827" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG10458" /db_xref="UniProtKB/Swiss-Prot:P17867" /translation="MIAIYVRVSTEEQAIKGSSIDSQIEACIKKAGTKDVLKYADEGF SGELLERPALNRLREDASKGLISQVICYDPDRLSRKLMNQLIIDDELRKRNIPLIFVN GEYANSPEGQLFFAMRGAISEFEKAKIKERTSSGRLQKMKKGMIIKDSKLYGYKFVKE KRTLEILEEEAKIIRMIFNYFTDHKSPFFGRVNGIALHLTQMGVKTKKGAKVWHRQVV RQILMNSSYKGEHRQYKYDTEGSYVSKQAGNKSIIKIRPEEEQITVTIPAIVPAEQWD YAQELLGQSKRKHLSISPHNYLLSGLVRCGKCGNTMTGKKRKSHGKDYYVYTCRKNYS GAKDRGCGKEMSENKLNRHVWGEIFKFITNPQKYVSFKEAEQSNHLSDELELIEKEIE KTKKGRKRLLTLISLSDDDDLDIDEIKAQIIELQKKQNQLTEKCNEIQSKMKVLDDTS SSENALKRAIDYFQSIGADNLTLEDKKTIVNFIVKEVTIVDSDTIYIETY*" /label="spoIVCA CDS" gene complement(2238136..2239638) /gene="spoIVCA" /locus_tag="BSU_25770" /old_locus_tag="BSU25770" /label="spoIVCA gene" downshifts complement(2238152) /Source="Nicolas_upshifts" /id="D1337" /incds=1 /nref=21 /ntot=131 /MaxReadThrough="2.50085" /MaxDrop="6.35891" /score="-0.144589925" /energy="-9.3" /TU="NA" /idTUdmin="U2008" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2239745..2239763) /Source="Nicolas_upshift_promotors" /id="U2008" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1098 /SigmaFactorBS="gaaacgtttaataacactatagtttaatttaaaatctcCTCA TTtggacaaacagctgttACATAGCATTACCCAAGGGgtgatgcattttatgaaagtg a" /listShort="spoIVCA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2239763) /Source="Nicolas_upshifts" /id="U2008" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1098 /SigmaFactorBS="gaaacgtttaataacactatagtttaatttaaaatctcCTCA TTtggacaaacagctgttACATAGCATTACCCAAGGGgtgatgcattttatgaaagtg a" /listShort="spoIVCA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2239765..2240066) /Source="Nicolas_S_feature" /locus_tag="new_2655000_2655301_c" /HighExp="dia5, Diami, S8, S7, dia15, C30, G135, S6, G180, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.974" /TUlongSig="NA" /TUlongPSig="NA" /label="S972" promotor_-35 complement(2239780..2239785) /Source="Nicolas_upshift_promotors" /id="U2008" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1098 /SigmaFactorBS="gaaacgtttaataacactatagtttaatttaaaatctcCTCA TTtggacaaacagctgttACATAGCATTACCCAAGGGgtgatgcattttatgaaagtg a" /listShort="spoIVCA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2240087..2240506) /gene="arsC" /locus_tag="BSU_25780" /old_locus_tag="BSU25780" /EC_number="1.20.4.4" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11698660, 16192272, 16905151, 8760915, 8969508, 9537360, 17303556, 21258851, 21904062, 23813734" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11698660, 16192272, 16905151, 8760915, 8969508, 9537360, 17303556, 21258851, 21904062, 23813734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thioredoxin-coupled arsenate reductase; skin element" /protein_id="NP_390455.1" /db_xref="EnsemblGenomes-Gn:BSU25780" /db_xref="EnsemblGenomes-Tr:CAB14519" /db_xref="GOA:P45947" /db_xref="InterPro:IPR014064" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:1JL3" /db_xref="PDB:1Z2D" /db_xref="PDB:1Z2E" /db_xref="PDB:2IPA" /db_xref="SubtiList:BG11304" /db_xref="UniProtKB/Swiss-Prot:P45947" /translation="MENKIIYFLCTGNSCRSQMAEGWAKQYLGDEWKVYSAGIEAHGL NPNAVKAMKEVGIDISNQTSDIIDSDILNNADLVVTLCGDAADKCPMTPPHVKREHWG FDDPARAQGTEEEKWAFFQRVRDEIGNRLKEFAETGK*" /label="arsC CDS" gene complement(2240087..2240506) /gene="arsC" /locus_tag="BSU_25780" /old_locus_tag="BSU25780" /label="arsC gene" downshifts complement(2240111) /Source="Nicolas_upshifts" /id="D1338" /incds=0 /nref=106 /ntot=239 /MaxReadThrough="3.85143" /MaxDrop="6.98965" /score="17.1730317" /energy="-8.6" /TU="U2009" /idTUdmin="U2009" /TUdmin="-1823" /isTUend="FALSE" /label="downshifts" CDS complement(2240518..>2240646) /gene="arsB" /locus_tag="Delta6_pseudo_BSU_25790" /old_locus_tag="BSU25790" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9537360, 15849754, 16850406, 16905151; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arsenite efflux transporter; skin element" /protein_id="NP_390456.2" /db_xref="EnsemblGenomes-Gn:BSU25790" /db_xref="EnsemblGenomes-Tr:CAB14520" /db_xref="GOA:P45946" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004706" /db_xref="SubtiList:BG11303" /db_xref="UniProtKB/Swiss-Prot:P45946" /NCBI_locus_tag="A8O17_RS20905" /modified_by="User" /translation="YRIHSGAAFAAVIGPLVEVPVMIALVKVALWFQRKYFGSHSM*" /label="Delta6_pseudo_BSU_25790" gene complement(2240518..>2240646) /gene="arsB" /locus_tag="Delta6_pseudo_BSU_25790" /old_locus_tag="BSU25790" /NCBI_locus_tag="A8O17_RS20905" /modified_by="User" /label="Delta6_pseudo_BSU_25790" SCAR join(2240642,2240649) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="TFC7A" N_region 2240643..2240648 /note="EcoRV side (GATATC)" /created_by="User" /modified_by="User" /label="TFC7A" CDS <2240644..2241030 /NCBI_locus_tag="A8O17_RS12485" /NCBI_old_locus_tag="A8O17_12485" /inference="COORDINATES: similar to AA sequence:RefSeq:NP_390515.1" /note="incomplete; partial in the middle of a contig; missing N-terminus; Derived by automated computational analysis using gene prediction method: Protein Homology." /pseudo /codon_start=1 /transl_table=11 /product="ImmA/IrrE family metallo-endopeptidase" /locus_tag="Delta6_pseudo_BSU_26380" /modified_by="User" /translation="ISSFALKHSGIYNICLDSRKSRTEQWYDFAHEFCHIYRHEGDKK TMPATWTDYLDWQSNYFTYHFCIPTCMLRNINLPYIQSHAIENVAWLFKVSPSFAKKR LSIYYRKLTQHLFSQTVTGNLCPPFL*" /label="Delta6_pseudo_BSU_26380" gene <2240644..2241030 /NCBI_locus_tag="A8O17_RS12485" /NCBI_old_locus_tag="A8O17_12485" /pseudo /locus_tag="Delta6_pseudo_BSU_26380" /modified_by="User" /label="Delta6_pseudo_BSU_26380" misc_feature complement(2240997..2241015) /Source="Nicolas_upshift_promotors" /id="U2034" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.888111888111888" /psig="0.888111888111888" /xcortree=1184 /SigmaFactorBS="acgtctttttttgtttttttcaatgcgcgcaaatgcatgagg atttcattattcattacaaaaaggggggGCATAAATTTCCCGTAACAgtttgactaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2241012..2241428 /gene="sigKc" /locus_tag="BSU_26390" /old_locus_tag="BSU26390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2163341, 7704261, 8969508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2163341, 7704261, 8969508; Product type f: factor" /pseudo /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma-K factor precursor (Sigma-27) (C-terminal fragment)" /db_xref="GOA:P12254" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="PSEUDO:CAB14580.1" /db_xref="SubtiList:BG10919" /db_xref="UniProtKB/Swiss-Prot:P12254" /translation="MPPLFVMNNEILMHLRALKKTKKDVSLHDPIGQDKEGNEISLID VLKSENEDVIDTIQLNMELEKVKQYIDILDDREKEVIVGRFGLDLKKEKTQREIAKEL GISRSYVSRIEKRALMKMFHEFYRAEKEKRKKAKGK*" /label="sigKc CDS" gene 2241012..2241428 /gene="sigKc" /locus_tag="BSU_26390" /old_locus_tag="BSU26390" /pseudo /label="sigKc gene" misc_feature 2241017..2241031 /Source="Nicolas_upshift_promotors" /id="U2035" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.647352647352647" /psig="0.217782217782218" /xcortree=1060 /SigmaFactorBS="tcaacatttatttagtcaaactgttacgggaaatttatgccC CCCCTTTTTGTAATgaataatgaaatcctcatgcatttgcgcgcattgaaaaaaacaa a" /listShort="spoIIIC, S984" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2241025) /Source="Nicolas_upshifts" /id="U2034" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.888111888111888" /psig="0.888111888111888" /xcortree=1184 /SigmaFactorBS="acgtctttttttgtttttttcaatgcgcgcaaatgcatgagg atttcattattcattacaaaaaggggggGCATAAATTTCCCGTAACAgtttgactaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 2241036 /Source="Nicolas_upshifts" /id="U2035" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.647352647352647" /psig="0.217782217782218" /xcortree=1060 /SigmaFactorBS="tcaacatttatttagtcaaactgttacgggaaatttatgccC CCCCTTTTTGTAATgaataatgaaatcctcatgcatttgcgcgcattgaaaaaaacaa a" /listShort="spoIIIC, S984" /GFF_Attribute="listLong" /label="upshifts" downshifts 2241412 /Source="Nicolas_upshifts" /id="D1357" /incds=0 /nref=50 /ntot=108 /MaxReadThrough="3.60274" /MaxDrop="5.60264" /score="-0.848064104" /energy="-4.5" /TU="U2035" /idTUdmin="U2033" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS 2241428..2241544 /locus_tag="BSU_26399" /old_locus_tag="BSU26399" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513982.1" /translation="MQKKPDLILRLSLFERVMKIIFFIADKLSEKDRQDRNK*" /label="hypothetical protein CDS" gene 2241428..2241544 /locus_tag="BSU_26399" /old_locus_tag="BSU26399" /label="gene" S_feature 2241457..2242791 /Source="Nicolas_S_feature" /locus_tag="new_2701783_2703117" /HighExp="S8, S6, S7, S5, S4, BT, B36, dia15, C30, H2O2" /AntisenseName="psiE" /AntisenseCor="0.376363934894826" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="0.117191" /TUshortSig="Sig-" /TUshortPSig="0.218" /TUlongSig="NA" /TUlongPSig="NA" /label="S984" downshifts complement(2241575) /Source="Nicolas_upshifts" /id="D1358" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="3.25265" /MaxDrop="3.18978" /score="3.17084908" /energy="-14.7" /TU="NA" /idTUdmin="U2036" /TUdmin=66 /isTUend="FALSE" /label="downshifts" CDS complement(2241653..2241817) /gene="yrkS" /locus_tag="BSU_26400" /old_locus_tag="BSU26400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390517.1" /db_xref="EnsemblGenomes-Gn:BSU26400" /db_xref="EnsemblGenomes-Tr:CAB14581" /db_xref="SubtiList:BG11785" /db_xref="UniProtKB/Swiss-Prot:P54446" /translation="MKVIIIEGLQTDKCMNDCYHYLIKLYRQEIQGDSNISWNKRSRD RASTARSRPV*" /label="yrkS CDS" gene complement(2241653..2241817) /gene="yrkS" /locus_tag="BSU_26400" /old_locus_tag="BSU26400" /label="yrkS gene" promotor_-10 complement(2241747..2241766) /Source="Nicolas_upshift_promotors" /id="U2036" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.824175824175824" /psig="0.975024975024975" /xcortree=1403 /SigmaFactorBS="aggggtgatgtattttatgaaggtaataatcatcgagggact gcaAACTGACAaatgcatgaacgatTGCTATCATTATTTAATAAAactttataggcag g" /listShort="yrkS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2241773) /Source="Nicolas_upshifts" /id="U2036" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.824175824175824" /psig="0.975024975024975" /xcortree=1403 /SigmaFactorBS="aggggtgatgtattttatgaaggtaataatcatcgagggact gcaAACTGACAaatgcatgaacgatTGCTATCATTATTTAATAAAactttataggcag g" /listShort="yrkS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2241781..2241788) /Source="Nicolas_upshift_promotors" /id="U2036" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.824175824175824" /psig="0.975024975024975" /xcortree=1403 /SigmaFactorBS="aggggtgatgtattttatgaaggtaataatcatcgagggact gcaAACTGACAaatgcatgaacgatTGCTATCATTATTTAATAAAactttataggcag g" /listShort="yrkS" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2241951) /Source="Nicolas_upshifts" /id="D1359" /incds=0 /nref=79 /ntot=219 /MaxReadThrough="1.20909" /MaxDrop="4.40328" /score="39.3560776" /energy="-10.6" /TU="NA" /idTUdmin="U2036" /TUdmin="-310" /isTUend="FALSE" /label="downshifts" CDS complement(2242362..2242778) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12897016, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="phosphate starvation inducible protein" /protein_id="NP_390518.2" /db_xref="EnsemblGenomes-Gn:BSU26410" /db_xref="EnsemblGenomes-Tr:CAB14582" /db_xref="GOA:P54445" /db_xref="InterPro:IPR009315" /db_xref="InterPro:IPR020948" /db_xref="SubtiList:BG11784" /db_xref="UniProtKB/Swiss-Prot:P54445" /translation="MRFSNKFKKVPYLLQALLNVCLFFLALALSALLISETWYIVLFV YKSLFNKVDSYYEMLGELLIFFMYFEFIALIIKYFKSDFHFPLRYFIYIGITAVIRLI IIDHDQAISTFWWAMAILAMICGFFIANRRNSVVEH*" /label="psiE CDS" gene complement(2242362..2242778) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /label="psiE gene" CDS complement(2242824..2244122) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YrkP]" /protein_id="NP_390519.1" /db_xref="EnsemblGenomes-Gn:BSU26420" /db_xref="EnsemblGenomes-Tr:CAB14583" /db_xref="GOA:P54444" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11783" /db_xref="UniProtKB/Swiss-Prot:P54444" /translation="MAHLKFTLTKKLALLIMVAAIVSGVIFLTLQKITDDLIEGYLSS EEYYHEESARYIQKFSKYVSENELSTSDRKAFGEWVKKENYINLTIFKDQELQYDSIY SESDYGKEKLTQYAQNHSHPVKFSDGEGRVIIDGFYSSRYYDLAFALDLLGATLIFLI IVLFGIRQSLRYLKTIHQEIHILEGGELDYEMTIKGHDELAMIAKSIEDLRKAFLDKL KAIEELQAESRSLVTEMSHDMRTPLTSLIMNLEFAKKEGGEAGASKDRYVANAYGKAL QLKSLSDNLFAYFLLNKEYEADLETVAVKEVIYDLISDQIAILHQEHFRVHISGELPE TYINVNLEELGRVFDNVMSNLLKYADPEEKISITFVSDQEIFEIHVSNTIKLADITPE SNGLGERSIARMMSRMQGQFHSIQKNSKYYIVLRFWNTKM*" /label="yrkQ CDS" gene complement(2242824..2244122) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /label="yrkQ gene" CDS complement(2244109..2244804) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18175906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18175906; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YrkQ]" /protein_id="NP_390520.1" /db_xref="EnsemblGenomes-Gn:BSU26430" /db_xref="EnsemblGenomes-Tr:CAB14584" /db_xref="GOA:P54443" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11782" /db_xref="UniProtKB/Swiss-Prot:P54443" /translation="MAYRILVVEDDEDIGDLLEESLTRAGYEVLRAKDGKRALQLVND SLDLVILDIMMPGISGIETCQHIRKSSNVPILFLTARSSTLDKTEGLLAGGDDYMTKP FSEEELHARVIAQLRRYTIYQEKKEQEETFLIGGKLRVSEEFNEVWKEEKQIKLSDLE YRILKLLMNKRNKIFSAQNIYESVWGQPYFYCSNNTVMVHIRKLRSKIEDDPARPVYI KTEWGRGYRFGAS*" /label="yrkP CDS" gene complement(2244109..2244804) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /label="yrkP gene" misc_feature complement(2244870..2244887) /Source="Nicolas_upshift_promotors" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2244879) /Source="Nicolas_upshifts" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2244965..2244971 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2244978..2244996 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2244993 /Source="Nicolas_upshifts" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2245072..2246289 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390521.1" /db_xref="EnsemblGenomes-Gn:BSU26440" /db_xref="EnsemblGenomes-Tr:CAB14585" /db_xref="GOA:P54442" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11781" /db_xref="UniProtKB/Swiss-Prot:P54442" /translation="MIVQKEGRGQPVSLRERVHFLDIVRGFALLGIIIVNYFLIVDSV KGFEMASDDVLHKLVSWFAEGKFVTLFSFLFGVGFMIFMDRAAQKVESPNKLFARRLS ILLGFGILHITFVWVGDILAFYAVSGFLLLAFYKRTAKTVLRWIIALIVFQFLTPVFT MLYNVINTAGSKNPNFSEFTLFSHSSLTYMESISTRWTDMVTMAAGSFSMIYSMFLMF LLGVYFVKMEFFKDMEAKKPIWKRIWIISTIAFLITQSSILLDMFNLSENMLWKDISS VLGQNGGLTGSMFYMSTFAMLFLYLPQLRGPMMIFTKVGRMSLTCYLLHSIIGTVLFL RYGFGLADHIQSAGTFMFSLAVYFVLMSFSTLWLKRFRYGPMELVWRKLTYGKVNGSP KATPLHSEKSIQK*" /label="yrkO CDS" gene 2245072..2246289 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /label="yrkO gene" promotor_-35 2245531..2245538 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2245553..2245572 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2245569 /Source="Nicolas_upshifts" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2246208..2246456 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513983.1" /translation="MAQADVRQSKRESQSNSAAFGKIYSEITPLHRLHDFKLVLLNEA GIKRTDLIYGLVIFISFRLLWANKSTRVYSMCIAHDRI*" /label="hypothetical protein CDS" gene 2246208..2246456 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /label="gene" S_feature complement(2246385..2247432) /Source="Nicolas_S_feature" /locus_tag="new_2706711_2707758_c" /HighExp="Diami, C30, dia15, dia5, Lbstat, S8, C90, G180, H2O2, G135" /AntisenseName="yrkN" /AntisenseCor="0.40539464433869998" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S985" CDS 2246801..2247358 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /EC_number="2.3.-.-" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390522.1" /db_xref="EnsemblGenomes-Gn:BSU26450" /db_xref="EnsemblGenomes-Tr:CAB14586" /db_xref="GOA:P54441" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11780" /db_xref="UniProtKB/Swiss-Prot:P54441" /translation="MKTKNEPKVILELAKESDLPEFQKKLQEAFAIAVIETFGDCEDG PIPSDNDVQESFNAPGAVVYHILQDGKNVGGAVVRINSQTNHNSLDLFYVSPEYHSQG IGLSAWKAIEAQYPDTVLWETVTPYFEKRNINFYVNKCGFHIVEFYNEHHSNPHMHRN GREDDKPLLNDDDFFRFVKIMKKKD*" /label="yrkN CDS" gene 2246801..2247358 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /label="yrkN gene" S_feature 2247359..2247481 /Source="Nicolas_S_feature" /locus_tag="new_2707685_2707807" /HighExp="S8, Sw, C30, S7, BC, C90, Lbstat, Mal, LoTm, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S986" S_feature complement(2247434..2247848) /Source="Nicolas_S_feature" /locus_tag="new_2707760_2708174_c" /HighExp="M0t90, M40t90, Lbstat, dia5, LPhT, dia15, M9-stat, Lbtran, C90, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S987" downshifts complement(2247477) /Source="Nicolas_upshifts" /id="D1360" /incds=0 /nref=81 /ntot=255 /MaxReadThrough="5.45539" /MaxDrop="5.6563" /score="-3.35079978" /energy="-23.7" /TU="U2041,U2042,U2044,U2045" /idTUdmin="U2042" /TUdmin="-182" /isTUend="FALSE" /label="downshifts" CDS complement(2247849..2248373) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /EC_number="1.6.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase" /protein_id="NP_390524.2" /db_xref="EnsemblGenomes-Gn:BSU26470" /db_xref="EnsemblGenomes-Tr:CAB14588" /db_xref="GOA:P54439" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11778" /db_xref="UniProtKB/Swiss-Prot:P54439" /translation="MKTLVIVIHPNLETSVVNKTWMNRLKQEKDITVHDLYGEYPNFI IDVEKEQQLLLDHERIVFQFPMYWYSSPALLKQWEDDVLTHGWAYGTGGTKLHGKELL LAISLGAQESDYQAGGEYNITISELIRPFQVTANYIGMRFLPAFTQYGTLHLSKEDVK NSAERLVDYLKAEH*" /label="yrkL CDS" gene complement(2247849..2248373) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /label="yrkL gene" promotor_-35 2248221..2248228 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2248239..2248258 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2248253 /Source="Nicolas_upshifts" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2248374..2248461) /Source="Nicolas_S_feature" /locus_tag="new_2708700_2708787_c" /HighExp="dia5, Etha, dia15, M9-stat, M0t90, Lbtran, Diami, C90, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S988" promotor_-10 complement(2248456..2248475) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2248461) /Source="Nicolas_upshifts" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2248463..>2248599) /Source="Nicolas_S_feature" /locus_tag="new_2708789_2708942_c" /HighExp="M0t90, M9-stat, Lbstat, M40t90, T1.30H, C90, Lbtran, T0.30H, dia15, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S989" promotor_-35 complement(2248490..2248497) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(2248599,2248606) /created_by="User" /note="deletion occured in betwen marked nucleotides " /modified_by="User" /label="IIG_Bs12" N_region 2248600..2248605 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs12" CDS complement(2248658..2249188) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11700344, 15019740, 17675383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11700344, 15019740, 17675383; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma-Z)" /protein_id="NP_390561.1" /db_xref="EnsemblGenomes-Gn:BSU26840" /db_xref="EnsemblGenomes-Tr:CAB14625" /db_xref="GOA:O05409" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014304" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11976" /db_xref="UniProtKB/Swiss-Prot:O05409" /translation="MNIEDLWDQFHQPLKTYISHRVNDQSIVDDLLQIVFMKIQVHLP NLIDEQKIDSWIYRITRNTIIDFYRTKKTSEILPDVLHFNDSAEEENFTKEATVCIRS TIKRLPEKYREALELTDFQGLSQKELSEKLGISYSGAKSRVQRGRGKLKQLLEGCCHI EADRYGNIVDFRILKE*" /label="sigZ CDS" gene complement(2248658..2249188) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /label="sigZ gene" promotor_-10 complement(2249234..2249253) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2249257) /Source="Nicolas_upshifts" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2249267..2249274) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2249323..2250303 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23990306, 25326299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_390562.2" /db_xref="EnsemblGenomes-Gn:BSU26850" /db_xref="EnsemblGenomes-Tr:CAB14626" /db_xref="GOA:O05408" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG12309" /db_xref="UniProtKB/Swiss-Prot:O05408" /translation="MEYTYLGRTGLRVSRLCLGTMNFGVDTDEKTAFRIMDEALDNGI QFFDTANIYGWGKNAGLTESIIGKWFAQGGQRREKVVLATKVYEPISDPNDGPNDMRG LSLYKIRRHLEGSLKRLQTDHIELYQMHHIDRRTPWDEIWEAFETQVRSGKVDYIGSS NFAGWHLVKAQAEAEKRRFMGLVTEQHKYSLLERTAEMEVLPAARDLGLGVVAWSPLA GGLLGGKALKSNAGTRTAKRADLIEKHRLQLEKFSDLCKELGEKEANVALAWVLANPV LTAPIIGPRTVEQLRDTIKAVEISLDKEILRMLNDIFPGPGGETPEAYAW*" /label="yrpG CDS" gene 2249323..2250303 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /label="yrpG gene" CDS complement(2250577..2251893) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053381, 11566984, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative citrate transporter" /protein_id="NP_390563.1" /db_xref="EnsemblGenomes-Gn:BSU26860" /db_xref="EnsemblGenomes-Tr:CAB14627" /db_xref="GOA:O05407" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG12279" /db_xref="UniProtKB/Swiss-Prot:O05407" /translation="MLTILGFSMVTVFTILIMTKKVSPIVALTITPIVFALIGGFGKG IGDMILEGIQTVASSAALLLFAILFFGILIDAGLFDPLIEKILSIVKGDPVKIAIGSA VLAMLIALDGDGTTTYMITVSAMLPLYKRIGMNPMVMATLAMLSLSIVSGMTPWGGPA TRAISVLGLDPSDFFVPLLPTMLGGIACVIFLAFLMGRKERNRIGIVQLEPRHITKDS SQSYMAATLESEQLKRPRLIYLNLFLVISIMVFIVLGTKHPSVLFLIGFVLALTINYP NVKMQKERIAEHSGNAITVVLLVFSAGVFAGILSGTKMVDAIAGSLISIIPSSMGGFF PVIVALTSIPFTFVLSNDAYYFGMVPIFAEAASAYGIEPVEIARASIMGQPVHLMSPL VASTVLLVSMLKMDLGSFQRFAVKWAVITSLVITLLAIITGAITIL*" /label="yraO CDS" gene complement(2250577..2251893) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /label="yraO gene" S_feature complement(2251894..2252007) /Source="Nicolas_S_feature" /locus_tag="new_2745480_2745593_c" /HighExp="Lbtran, M40t90, Lbstat, HiTm, Mal, Gly, M0t90, S1, T1.0H, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1012" CDS complement(2252008..2252877) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (probes citrate or citrate-related metabolite)" /protein_id="NP_390564.1" /db_xref="EnsemblGenomes-Gn:BSU26870" /db_xref="EnsemblGenomes-Tr:CAB14628" /db_xref="GOA:O07906" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12278" /db_xref="UniProtKB/Swiss-Prot:O07906" /translation="MDEKDWILLKILHEEQSVTKTAERLFTSQPSITYRLKKIEEIFG IELFTKRHKGITFTAEGEHLVAYARRMLQELQDTKDHISNLSKEVQGHLRLGVSSNFA QYKLPKLLREFSTMYPNVQYSVQTGWSTDVMKLLDAGIVQVGILRGSHRWKGVEERLT REKLHIISKKPITIEQLPFLPFIKYKTDASLKTIIEDWMHTNLKQAPIIAMEVDRQET CKEMVKHGLGYSIAPEICLQESDHLYTMELYNAKGKPLMRDTWLMYDQKSLGIKLVKA FIDFLKGEQMVTI*" /label="yraN CDS" gene complement(2252008..2252877) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /label="yraN gene" promotor_-10 complement(2252900..2252919) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2252917) /Source="Nicolas_upshifts" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2252934..2252939) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2252984..2252985) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2252992) /Source="Nicolas_upshifts" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2253022..2253023) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2253022..2254125 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /EC_number="5.3.3.7" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11294638, 12473114, 14702315, 17567742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate isomerase" /protein_id="NP_390565.2" /db_xref="EnsemblGenomes-Gn:BSU26880" /db_xref="EnsemblGenomes-Tr:CAB14629" /db_xref="GOA:O07931" /db_xref="InterPro:IPR007400" /db_xref="SubtiList:BG12277" /db_xref="UniProtKB/Swiss-Prot:O07931" /translation="MVKTNVTIMRGGTSKGVFFHESAMPNNKNEWEPFLLDVMGSPDK RQIDGLGGGNSLTSKVAIIKKAYTSDIDVHYTFGQVSISEEKVDFKGNCGNISAAVGP FAIEEGLVKAKEPMTAVRILNTNTNKMIIAEVEVEDGQVKYDGDVTISGVPGSGSPIY LNFHDAAGSVTGHLLPTGNSSEFLDTSQGQIEVSIIDYANPLVFVEASSIGLDGTELA EEFTDLQLAQFEELRSIAAEKCGFASRFSATKLSPAVPKLAIVAKPEKYKDSTGAWHS SVEMDLHIRMMSMQKPHQALAVTGAICTTRALSVEGAIPARIAKNHSTKVRLAHSSGI IETMVEPTGIKIVRTARRIMDGTVYTHGDYQMM*" /label="prpF CDS" gene 2253022..2254125 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /label="prpF gene" misc_feature 2254015..2254034 /Source="Nicolas_upshift_promotors" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2254021 /Source="Nicolas_upshifts" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2254372) /Source="Nicolas_upshifts" /id="D1374" /incds=0 /nref=123 /ntot=254 /MaxReadThrough="2.33762" /MaxDrop="7.47213" /score="6.31571576" /energy="-8.7" /TU="U2071" /idTUdmin="U2071" /TUdmin="-33" /isTUend="FALSE" /label="downshifts" CDS complement(2254398..2255231) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /EC_number="3.2.1.132" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11065371, 11320136, 1664582, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11065371, 11320136, 1664582, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chitosanase" /protein_id="NP_390566.1" /db_xref="EnsemblGenomes-Gn:BSU26890" /db_xref="EnsemblGenomes-Tr:CAB14630" /db_xref="GOA:O07921" /db_xref="InterPro:IPR000400" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG11923" /db_xref="UniProtKB/Swiss-Prot:O07921" /translation="MKISMQKADFWKKAAISLLVFTMFFTLMMSETVFAAGLNKDQKR RAEQLTSIFENGTTEIQYGYVERLDDGRGYTCGRAGFTTATGDALEVVEVYTKAVPNN KLKKYLPELRRLAKEESDDTSNLKGFASAWKSLANDKEFRAAQDKVNDHLYYQPAMKR SDNAGLKTALARAVMYDTVIQHGDGDDPDSFYALIKRTNKKAGGSPKDGIDEKKWLNK FLDVRYDDLMNPANHDTRDEWRESVARVDVLRSIAKENNYNLNGPIHVRSNEYGNFVI K*" /label="csn CDS" gene complement(2254398..2255231) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /label="csn gene" misc_feature complement(2255261..2255280) /Source="Nicolas_upshift_promotors" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2255270) /Source="Nicolas_upshifts" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2255436..2255440 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2255451..2255673 /Source="Nicolas_S_feature" /locus_tag="new_2749037_2749259" /HighExp="Lbstat, M9-stat, B60, M0t90, M40t90, T1.30H, T2.0H, T3.0H, T2.30H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97565800000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1013" upshifts 2255451 /Source="Nicolas_upshifts" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2255455..2255474 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2255674..2255937 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390567.1" /db_xref="EnsemblGenomes-Gn:BSU26900" /db_xref="EnsemblGenomes-Tr:CAB14631" /db_xref="GOA:O07917" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12276" /db_xref="UniProtKB/Swiss-Prot:O07917" /translation="MAYVKATAILPEKLISEIQKYVQGKTIYIPKPESSHQKWGACSG TRKLIDDRNASIKKAFKNGKTIHQLSDEYHLSIETIKKIVYSK*" /label="yraL CDS" gene 2255674..2255937 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /label="yraL gene" downshifts 2255925 /Source="Nicolas_upshifts" /id="D1375" /incds=0 /nref=71 /ntot=223 /MaxReadThrough="1.7419" /MaxDrop="4.94534" /score="-1.04752822" /energy="-9.9" /TU="NA" /idTUdmin="U2072" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS 2256074..2256889 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390568.2" /db_xref="EnsemblGenomes-Gn:BSU26910" /db_xref="EnsemblGenomes-Tr:CAB14632" /db_xref="GOA:O07937" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12275" /db_xref="UniProtKB/Swiss-Prot:O07937" /translation="MTINNGTLQVPGANIHYQVRGSGPIILLVHGGGGDADKFHHVAN HLANWYTVVTYDRRGHSRSNLANQIEGYRVETHSDDAHRLLAKITNKPAYVFGSSSGA VIGLDLCIRHPEQVHVMIPHEPILLQLLHGNELKQAEQFMEDLKKNHRSEVIKLMSRL ETDEQSKAVLTKRLLGNSTYFTEYEIQGILSYTLDFEALKTVFTSSPMKILPAGGSAS RELFPYRCANALAEQLETEWVEFPGNHTGYTMYHKEFSERLHDMLEKEKKHTC*" /label="yraK CDS" gene 2256074..2256889 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /label="yraK gene" S_feature complement(2257224..2257296) /Source="Nicolas_S_feature" /locus_tag="new_2750810_2750882_c" /HighExp="BC, Lbstat, Sw, M40t90, M0t90, S2, BI, BT, S3, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1014" downshifts complement(2257267) /Source="Nicolas_upshifts" /id="D1376" /incds=0 /nref=44 /ntot=205 /MaxReadThrough="1.43644" /MaxDrop="4.78753" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2073" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2257297..2257653) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390569.2" /db_xref="EnsemblGenomes-Gn:BSU26920" /db_xref="EnsemblGenomes-Tr:CAB14633" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12274" /db_xref="UniProtKB/Swiss-Prot:O07934" /translation="MTKLKMLSMLTVMIASLFIFSSQALAVQYFTVSTSSGAPVNMRS GPGTNYPIMLSIPSGSRVPYYCYAYGTTVTGKYGTSNIWDQIQWKDSRGVVNIGYVSD TYVYTGSDGPVGYKCN*" /label="yraJ CDS" gene complement(2257297..2257653) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /label="yraJ gene" CDS complement(2257706..2258065) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390570.2" /db_xref="EnsemblGenomes-Gn:BSU26930" /db_xref="EnsemblGenomes-Tr:CAB14634" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12273" /db_xref="UniProtKB/Swiss-Prot:O07909" /translation="MNKLKRLSMLTVMIASVFIFSSHALAAQYYTVSTSSGAPVNMRS GPGTSWGIVTTIPSGTRIPIYCYKTGTTVTGKYGTSNIWNYTERTLASGEIVPGFVSD TYMYTGSDGPVVPKCSW*" /label="yraI CDS" gene complement(2257706..2258065) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /label="yraI gene" misc_feature complement(2258158..2258177) /Source="Nicolas_upshift_promotors" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2258168) /Source="Nicolas_upshifts" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2258337..2258438) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513987.1" /translation="MIGEKGGVSMNREEAWIQGSSTLIELIGGNEAA*" /label="hypothetical protein CDS" gene complement(2258337..2258438) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /label="gene" S_feature complement(2258478..2258580) /Source="Nicolas_S_feature" /locus_tag="new_2752064_2752166_c" /HighExp="M40t90, LBGstat, M40t45, M0t90, Lbstat, Lbtran, LBGtran, LPhT, ferm, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.575" /TUlongSig="NA" /TUlongPSig="NA" /label="S1015" downshifts complement(2258520) /Source="Nicolas_upshifts" /id="D1377" /incds=0 /nref=19 /ntot=188 /MaxReadThrough="2.12056" /MaxDrop="4.09264" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2074" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2258581..2258967) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390571.1" /db_xref="EnsemblGenomes-Gn:BSU26940" /db_xref="EnsemblGenomes-Tr:CAB14635" /db_xref="GOA:O07918" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12272" /db_xref="UniProtKB/Swiss-Prot:O07918" /translation="MKLLQIRLLVNDFKKSVEFYKDSLGLPISWLENEMEYALFDNGE TKIELLSRETMAEIVGEEKKSLEGEAQSKFLLQFKVEDVDKTYDDLHEKGVKCENKPH DRKEWSARVAHFRDPDHNLIEIYKML*" /label="yraH CDS" gene complement(2258581..2258967) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /label="yraH gene" misc_feature complement(2259009..2259025) /Source="Nicolas_upshift_promotors" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2259025) /Source="Nicolas_upshifts" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2259158..2259164 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2259179..2259190 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2259179 /Source="Nicolas_upshifts" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="upshifts" CDS 2259216..2259461 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390572.1" /db_xref="EnsemblGenomes-Gn:BSU26950" /db_xref="EnsemblGenomes-Tr:CAB14636" /db_xref="GOA:O07919" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG12271" /db_xref="UniProtKB/Swiss-Prot:O07919" /translation="MDHQTLAAHEAVDLHEIVNFKTLCIAKSKLMQGLVFDQELKDLM EKDVQQSIQDLTELQAVYERASFQAPVPQSRPTPIIN*" /label="yraG CDS" gene 2259216..2259461 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /label="yraG gene" CDS 2259479..2259847 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390573.1" /db_xref="EnsemblGenomes-Gn:BSU26960" /db_xref="EnsemblGenomes-Tr:CAB14637" /db_xref="GOA:O07949" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG12270" /db_xref="UniProtKB/Swiss-Prot:O07949" /translation="MNNDHLDPINSLNVPELADTTFAMDFLIRAKEGVRNTAVALTET ASPDVRALLRKQLMQGIAMHQEITELMISKKWFHPYELSEQYKLDQLSAKNTIMVGNM NLFPDETNRKGMFDRTPDEH*" /label="yraF CDS" gene 2259479..2259847 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /label="yraF gene" CDS 2259866..2261002 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /EC_number="1.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7926692, 17586670; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (involving bacillithiol)" /protein_id="NP_390574.2" /db_xref="EnsemblGenomes-Gn:BSU26970" /db_xref="EnsemblGenomes-Tr:CAB14638" /db_xref="GOA:O06012" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR027399" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11902" /db_xref="UniProtKB/Swiss-Prot:O06012" /translation="MKAVTYQGIKNVVVKDVPDPKIEKSDDMIIKVTSTAICGSDLHL IHGFIPNMQEDYVIGHEPMGIVEEVGSGVTKLKKGDRVIIPFNIACGECFFCKNQLES QCDQSNDNGEMGAYFGYSGQTGGYPGGQAEYLRVPFANFTHFKIPESCEEPDEKLSVI ADAMTTGFWSVDNAGVKKGDTVIVLGCGPVGLFAQKFCWLKGAKRVIAVDYVNYRLQH AKRTNKVEIVNFEDHENTGNYLKEITKGGADVVIDAVGMDGKMSDLEFLASGLKLHGG TMSALVIASQAVRKGGTIQITGVYGGRYNGFPLGDIMQRNVNIRSGQAPVIHYMPYMF ELVSTGKIDPGDVVSHVLPLSEAKHGYDIFDSKMDDCIKVVLKP*" /label="adhB CDS" gene 2259866..2261002 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /label="adhB gene" CDS 2261021..2261218 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390575.1" /db_xref="EnsemblGenomes-Gn:BSU26980" /db_xref="EnsemblGenomes-Tr:CAB14639" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13780" /db_xref="UniProtKB/Swiss-Prot:O06011" /translation="MEYALHEVLEVQEMTAFKTLCLTKSKTMKALVSDPKLKEIMQQD VDITTRQLQEFASILSNAKQE*" /label="yraE CDS" gene 2261021..2261218 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /label="yraE gene" CDS 2261234..2261533 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390576.1" /db_xref="EnsemblGenomes-Gn:BSU26990" /db_xref="EnsemblGenomes-Tr:CAB14640" /db_xref="GOA:O06010" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG13779" /db_xref="UniProtKB/Swiss-Prot:O06010" /translation="MNPIIEYLTGMNVLTDQIIAMDLLISAKNGVRNYAMAATEAGTP EVKEVLIRHLEEALDMHEQLSSYMMEKGWYHPWNPDEQVKLNLKNIDTAIQLPTL*" /label="yraD CDS" gene 2261234..2261533 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /label="yraD gene" downshifts 2261524 /Source="Nicolas_upshifts" /id="D1378" /incds=0 /nref=11 /ntot=39 /MaxReadThrough="1.62449" /MaxDrop="3.8153" /score="-8.57687054" /energy="-10.7" /TU="NA" /idTUdmin="U2075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2261796..2262218) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 17962296, 19170879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 17962296, 19170879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulated by thiol-alkylation" /protein_id="NP_390578.2" /db_xref="EnsemblGenomes-Gn:BSU27000" /db_xref="EnsemblGenomes-Tr:CAB14642" /db_xref="GOA:O06008" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13777" /db_xref="UniProtKB/Swiss-Prot:O06008" /translation="MNIAQVAKQFGLTAATLRYYERVGLIPPVKRKDSGIRDYDEEDI KWIEFIKCMRNAGLSIEALIEYTTLFTEGDRTVEARKNILADERQRLIEKRKEIDETI KRLDTKIKDYDGKLRENEAKLKSRPKTESLHGSVEQRR*" /label="adhR CDS" gene complement(2261796..2262218) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /label="adhR gene" promotor_-35 2262216..2262219 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-35" promotor_-10 2262235..2262254 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-10" S_feature 2262250..2262400 /Source="Nicolas_S_feature" /locus_tag="new_2755836_2755986" /HighExp="Diami, dia15, dia5, H2O2, S8, Paraq, S5, G180, S6, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1016" upshifts 2262250 /Source="Nicolas_upshifts" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="upshifts" promotor_-10 complement(2262253..2262272) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2262260) /Source="Nicolas_upshifts" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2262286..2262293) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2262369..2262388) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-10" upshifts complement(2262377) /Source="Nicolas_upshifts" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="upshifts" CDS 2262401..2262595 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /EC_number="4.1.1.44" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17962296, 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxymuconolactone decarboxylase" /protein_id="YP_009513988.1" /db_xref="EnsemblGenomes-Gn:BSU27009" /db_xref="EnsemblGenomes-Tr:CAX52671" /db_xref="InterPro:IPR029032" /db_xref="UniProtKB/TrEMBL:C0H460" /translation="MANKHTAGREQLGEFAPKFAELHDDVLFGDIWAREEELSSRDRS MITVSALITDCFSAYKSGSF*" /label="yrzP CDS" gene 2262401..2262595 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /label="yrzP gene" promotor_-35 complement(2262403..2262410) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-35" promotor_-35 2262613..2262620 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-35" promotor_-10 2262636..2262655 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-10" upshifts 2262640 /Source="Nicolas_upshifts" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="upshifts" S_feature 2262641..2262725 /Source="Nicolas_S_feature" /locus_tag="new_2756227_2756311" /HighExp="LBGstat, dia15, Diami, LPhT, LBGtran, dia5, M40t90, Lbtran, H2O2, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.987, 0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1017" CDS 2262726..2263775 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase; carbonyl stressresponse" /protein_id="NP_390579.2" /db_xref="EnsemblGenomes-Gn:BSU27010" /db_xref="EnsemblGenomes-Tr:CAB14643" /db_xref="GOA:C0SPA5" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12562" /db_xref="UniProtKB/Swiss-Prot:C0SPA5" /translation="MCNQHQTRVLSVSHAKAKFEQTTIERRGLRPHDVLIDIKFSGIC HSDIHSAFDEWGGGIFPMVPGHEIAGVVTAVGTKVTKLAVGDRVGVGCFVDSCGECEY CLNAEEQFCTKGVVQTYNSVDYDGNPTYGGYSQKIVVTDRFVVRIPDRLEMDVASPLL CAGITTYSPLKHWNVGPGKKVAIVGVGGLGHLAIQFAHAMGAEVTVLSRSMNKKEEAL ELGANHYFATSDPATFTALAGRFDVILNTVSANLDVDAYLSMLRIDGTLVSVGAPAKP DTYSVFSLIMGRRSIAGSLVGGIQETQEMLDFAAEHGIEPKIEVIGADQVDEAYERIL RSDVRYRFVIDISTL*" /label="adhA CDS" gene 2262726..2263775 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /label="adhA gene" promotor_-35 2263843..2263850 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2263865..2263884 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2263878 /Source="Nicolas_upshifts" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="upshifts" CDS 2263906..2264415 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12775685, 17257049, 17933887, 24330391, 26774339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deglycase; general stress protecting enzyme; protects against methylglyoxal toxicity" /protein_id="NP_390580.2" /db_xref="EnsemblGenomes-Gn:BSU27020" /db_xref="EnsemblGenomes-Tr:CAB14644" /db_xref="GOA:O06006" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13776" /db_xref="UniProtKB/Swiss-Prot:O06006" /translation="MSKKIAVLVTDQFEDIEYTSPVKAYEEAGYSVVAIDLEAGKEVT GKHGEKVKIDKAISDVDASDFDALLIPGGFSPDLLRADDRPGEFAKAFVENKKPVFAI CHGPQVLIDTDLLKGKDITGYRSIRKDLINAGANYKDAEVVVSHNIVTSRTPDDLEAF NRESLNLLK*" /label="sufL CDS" gene 2263906..2264415 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /label="sufL gene" downshifts 2264384 /Source="Nicolas_upshifts" /id="D1379" /incds=0 /nref=178 /ntot=254 /MaxReadThrough="4.08169" /MaxDrop="5.1444" /score="24.8267602" /energy="-16.3" /TU="U2080" /idTUdmin="U2076" /TUdmin=528 /isTUend="FALSE" /label="downshifts" S_feature 2264429..2265534 /Source="Nicolas_S_feature" /locus_tag="new_2758015_2759120" /HighExp="Diami, dia5, Etha, dia15, LPhT, H2O2, Lbstat, Salt, Fru, Paraq" /AntisenseName="sacC" /AntisenseCor="0.18236909579254801" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.926" /label="S1018" CDS complement(2264457..2266490) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /EC_number="3.2.1.7" /EC_number="3.2.1.65" /EC_number="3.2.1.80" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7646030, 8057358, 10217495, 12224641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7646030, 8057358, 10217495, 12224641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levanase" /protein_id="NP_390581.1" /db_xref="EnsemblGenomes-Gn:BSU27030" /db_xref="EnsemblGenomes-Tr:CAB14645" /db_xref="GOA:P05656" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="PDB:4AZZ" /db_xref="PDB:4B1L" /db_xref="PDB:4B1M" /db_xref="SubtiList:BG10320" /db_xref="UniProtKB/Swiss-Prot:P05656" /translation="MKKRLIQVMIMFTLLLTMAFSADAADSSYYDEDYRPQYHFTPEA NWMNDPNGMVYYAGEYHLFYQYHPYGLQWGPMHWGHAVSKDLVTWEHLPVALYPDEKG TIFSGSAVVDKNNTSGFQTGKEKPLVAIYTQDREGHQVQSIAYSNDKGRTWTKYAGNP VIPNPGKKDFRDPKVFWYEKEKKWVMVLAAGDRILIYTSKNLKQWTYASEFGQDQGSH GGVWECPDLFELPVDGNPNQKKWVMQVSVGNGAVSGGSGMQYFVGDFDGTHFKNENPP NKVLWTDYGRDFYAAVSWSDIPSTDSRRLWLGWMSNWQYANDVPTSPWRSATSIPREL KLKAFTEGVRVVQTPVKELETIRGTSKKWKNLTISPASHNVLAGQSGDAYEINAEFKV SPGSAAEFGFKVRTGENQFTKVGYDRRNAKLFVDRSESGNDTFNPAFNTGKETAPLKP VNGKVKLRIFVDRSSVEVFGNDGKQVITDIILPDRSSKGLELYAANGGVKVKSLTIHP LKKVWGTTPFMSNMTGWTTVNGTWADTIEGKQGRSDGDSFILSSASGSDFTYESDITI KDGNGRGAGALMFRSDKDAKNGYLANVDAKHDLVKFFKFENGAASVIAEYKTPIDVNK KYHLKTEAEGDRFKIYLDDRLVIDAHDSVFSEGQFGLNVWDATAVFQNVTKES*" /label="sacC CDS" gene complement(2264457..2266490) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /label="sacC gene" downshifts complement(2264482) /Source="Nicolas_upshifts" /id="D1380" /incds=0 /nref=14 /ntot=60 /MaxReadThrough="0.56875" /MaxDrop="5.09923" /score="-2.07442916" /energy="-14.2" /TU="NA" /idTUdmin="U2081" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2266399..2266566) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513989.1" /translation="MPETDQLAQQSLLKVFKHEERSEGTNEKETDSSHDHVHPAVDYG IFGRCSRFKLL*" /label="hypothetical protein CDS" gene complement(2266399..2266566) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /label="gene" S_feature complement(2266491..2266646) /Source="Nicolas_S_feature" /locus_tag="new_2760077_2760232_c" /HighExp="UNK1, Fru, B60, T0.30H, M40t90, M0t90, ferm, LPh, GM-0.2, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.886" /TUlongSig="NA" /TUlongPSig="NA" /label="S1019" CDS complement(2266647..2267474) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IID component" /protein_id="NP_390582.1" /db_xref="EnsemblGenomes-Gn:BSU27040" /db_xref="EnsemblGenomes-Tr:CAB14646" /db_xref="GOA:P26382" /db_xref="InterPro:IPR004704" /db_xref="SubtiList:BG10319" /db_xref="UniProtKB/Swiss-Prot:P26382" /translation="MEKEKRLTKKEIFSMFIRSNFLLGSFNFERVQAMGYCYVMIPAI KKLYGPGAKRNEALQRHLEWFNTHPWLTAPIFGVTAAMEEEMANNKGIDGKAISGMKI GLMGPIAGVGDPIFWGTIRPVLAALGASLALGGNIAGPLLFFFLLNAIRLSTKYYGLK YGYVKGMEILQDLAGNRIQKLTEGASILGLFVMGALVSKWTTINIPIVVSRIKDESGK VDVQTVQNVLDSIMPGALPLGLTLLVAWMLRKGVNPLLIICGIFVIGILGYWAGFLA* " /label="levG CDS" gene complement(2266647..2267474) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /label="levG gene" CDS complement(2267495..2268304) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIC component" /protein_id="NP_390583.1" /db_xref="EnsemblGenomes-Gn:BSU27050" /db_xref="EnsemblGenomes-Tr:CAB14647" /db_xref="GOA:P26381" /db_xref="InterPro:IPR004700" /db_xref="SubtiList:BG10318" /db_xref="UniProtKB/Swiss-Prot:P26381" /translation="MSSLQIILLLIIAAITGIASVLDEGQTHRPLVACTLVGLVLGDL KTGIILGGTLELMALGWMNVGLAMAPDTAIASVISTILVITADQGIGEGIAVAVALAA AGQALTIFVRTITVFFIHRADQYAKAGNIKGIEIMHITAMVFQALRVMIPTLIVALIS VSAVQAFLGNIPDVITKGLQIGGGIIVVVGYAMVINMMNIPYLKPFFYIGFLLAAFTD FNLVGFGALGLCLALLYQQVMQKQSAHGAVAAASDSGSVAVYDDDDDDLDA*" /label="levF CDS" gene complement(2267495..2268304) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /label="levF gene" CDS complement(2268321..2268809) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /EC_number="2.7.1.202" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 9622354, 10589728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 9622354, 10589728; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIB component" /protein_id="NP_390584.1" /db_xref="EnsemblGenomes-Gn:BSU27060" /db_xref="EnsemblGenomes-Tr:CAB14648" /db_xref="GOA:P26380" /db_xref="InterPro:IPR004720" /db_xref="InterPro:IPR018455" /db_xref="InterPro:IPR036667" /db_xref="PDB:1BLE" /db_xref="SubtiList:BG10317" /db_xref="UniProtKB/Swiss-Prot:P26380" /translation="MNIVLARIDDRFIHGQILTRWIKVHAADRIIVVSDDIAQDEMRK TLILSVAPSNVKASAVSVSKMAKAFHSPRYEGVTAMLLFENPSDIVSLIEAGVPIKTV NVGGMRFENHRRQITKSVSVTEQDIKAFETLSDKGVKLELRQLPSDASEDFVQILRNV TK*" /label="levE CDS" gene complement(2268321..2268809) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /label="levE gene" CDS complement(2268809..2269249) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /EC_number="2.7.1.202" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIA component" /protein_id="NP_390585.1" /db_xref="EnsemblGenomes-Gn:BSU27070" /db_xref="EnsemblGenomes-Tr:CAB14649" /db_xref="GOA:P26379" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR013789" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10316" /db_xref="UniProtKB/Swiss-Prot:P26379" /translation="MISVIISGHGDFPIALKESSGMIFGEENNLIAVPFFKGEGIQTL QEKYHQALKDIPEEHEVLFLVDIFGGTPYNAAASFIAEDQRMDMAAGVNLPILLEVLS LREHLALKDLLNNLKAMSQQSFQVCSEHLEKVKTANQDTREDEL*" /label="levD CDS" gene complement(2268809..2269249) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /label="levD gene" downshifts 2269246 /Source="Nicolas_upshifts" /id="D1381" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="0.496260000000001" /MaxDrop="4.58461" /score="24.8267602" /energy="-16.3" /TU="NA" /idTUdmin="U2080" /TUdmin=3740 /isTUend="FALSE" /label="downshifts" misc_feature complement(2269286..2269304) /Source="Nicolas_upshift_promotors" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2269290) /Source="Nicolas_upshifts" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2269439..2272246) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NifA/NtrC family)" /protein_id="NP_390586.2" /db_xref="EnsemblGenomes-Gn:BSU27080" /db_xref="EnsemblGenomes-Tr:CAB14650" /db_xref="GOA:P23914" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10677" /db_xref="UniProtKB/Swiss-Prot:P23914" /translation="MRRIDKIYHQLKHNFHDSTLDHLLKIQGNSAKEIAEQLKMERSN VSFELNNLVRSKKVIKIKTFPVRYIPVEIAEKLFNKKWDTEMMEVKDLQAFSGNSKQN HQHISTNPLELMIGAKGSLKKAISQAKAAVFYPPNGLHMLLLGPTGSGKSLFANRIYQ FAIYSDILKAGAPFITFNCADYYNNPQLLLSQLFGHKKGSFTGAAEDKAGLVEQANGG ILFMDEIHRLPPEGQEMLFYFIDSGSYNRLGESEHKRTSNVLFICATTENPSSALLKT FLRRIPMTIHIPSLEERSLNERVDLTTFLLGKEAERIKKNLSVHIDVYNALIHSAKFG NVGQLKSNVQLVCAHGFLHNLDRNEVIELTVRDLPDEIKQEWMSSSKNMQRSKAISEY VNITTIISPIVEDETTKIDEDLSFNLYHLIEEKVKTLMKEGLSKKDINQYILTDVHLH VRSFFHHQAFQKDNLLTFVEDDVIQMTKQLKEIAEHELDCTFDRKFIYFLSMHIDAFL KRGKQIDVLNTQETDEIRDTHVKEYRVAMIFKDKIQEYFKVAIPEIEVIYLTMLIHSI KSLKENKRVGIIVAAHGNSTASSMVEVATELLGSTPIAAVDMPLTVSPSDILECVAEK MKQVDEGEGVLMLVDMGSLAMLESRLEEKTGISIKTISNVTTSMVLDAVRKVNYLNLN LHAIYQSVTKDFIELWERQPAASGKKKALVSICTTGSGTAKKLEDILTTIVNKASDTP IHILTVSSIKLANSIKEIEKEYEILATVGTKDPKINAPHVSLEVLIEGEGEKLIQQAI TKGSISLSNGLNEANIIVRELCEDSLKKYLVFLNPHHVIDMLLEWLQTVQDELGVIFN NAVLIKVIMHTAFAFERVIKQNPIAFSEEEEINDQLKEMVYVTERTLAPYEEKLGLRI SDDEKLFIAAIFAEEVHGQLF*" /label="levR CDS" gene complement(2269439..2272246) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /label="levR gene" misc_feature complement(2272462..2272481) /Source="Nicolas_upshift_promotors" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2272468) /Source="Nicolas_upshifts" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="upshifts" CDS 2272793..2272933 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513990.1" /translation="MTFLFYSAIQVESRVKNRATRHVTALKIVLKFKNKSIYSFKCYN IR*" /label="hypothetical protein CDS" gene 2272793..2272933 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /label="gene" misc_feature 2272914..2272933 /Source="Nicolas_upshift_promotors" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2272924 /Source="Nicolas_upshifts" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="upshifts" CDS 2272972..2274360 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17608695, 22084243; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small amino acid permease" /protein_id="NP_390587.2" /db_xref="EnsemblGenomes-Gn:BSU27090" /db_xref="EnsemblGenomes-Tr:CAB14651" /db_xref="GOA:O06005" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12556" /db_xref="UniProtKB/Swiss-Prot:O06005" /translation="MIGNSSKDNFGQQQKLSRGLKNRHIQLMAIGGAIGTGLFLGSGK SIHFAGPSILFAYLITGVFCFFIMRSLGELLLSNAGYHSFVDFVRDYLGNMAAFITGW TYWFCWISLAMADLTAVGIYTQYWLPDVPQWLPGLLALIILLIMNLATVKLFGELEFW FALIKVIAILALIVTGILLIAKGFSAASGPASLNNLWSHGGMFPNGWHGFILSFQMVV FAFVGIELVGLTAGETENPQKVIPKAINQIPVRILLFYVGALFVIMCIYPWNVLNPNE SPFVQVFSAVGIVVAASLINFVVLTSAASAANSALFSTSRMVYSLAKDHHAPGLLKKL TSSNVPSNALFFSSIAILIGVSLNYLMPEQVFTLITSVSTICFIFIWGITVICHLKYR KTRQHEAKANKFKMPFYPLSNYLTLAFLAFILVILALANDTRIALFVTPVWFVLLIIL YKVQTRRGHKVK*" /label="aapA CDS" gene 2272972..2274360 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /label="aapA gene" downshifts 2274349 /Source="Nicolas_upshifts" /id="D1382" /incds=0 /nref=7 /ntot=120 /MaxReadThrough="0.96985" /MaxDrop="3.54068" /score="11.8049306" /energy="-13" /TU="NA" /idTUdmin="U2083" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" S_feature complement(2274382..2274455) /Source="Nicolas_S_feature" /locus_tag="new_2767968_2768041_c" /HighExp="MG 120, LBGstat, MG 150, MG 90, S0, HPh, HiOs, GM-0.1, aero, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1020" downshifts complement(2274424) /Source="Nicolas_upshifts" /id="D1383" /incds=0 /nref=11 /ntot=121 /MaxReadThrough="1.79954" /MaxDrop="4.59487" /score="37.881034" /energy="-13" /TU="NA" /idTUdmin="U2084" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2274456..2275088) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16098526, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_390588.1" /db_xref="EnsemblGenomes-Gn:BSU27100" /db_xref="EnsemblGenomes-Tr:CAB14652" /db_xref="GOA:O05406" /db_xref="InterPro:IPR001123" /db_xref="InterPro:IPR004778" /db_xref="SubtiList:BG12304" /db_xref="UniProtKB/Swiss-Prot:O05406" /translation="MHSLLAYIPIAAMMVIIPGADTMLVMKNTLRYGPKAGRYNILGL ATGLSFWTVIAILGLSVVIAKSVILFTTIKYLGAAYLIYLGVKSFFAKSMFSLDDMQS QAKNMASSPKRYYKTSFMQGSLSNILNPKTVLVYVTIMPQFINLNGNINQQLIILASI LTLLAVLWFLFLVYIIDYAKKWMKNSKFQKVFQKITGIILVGFGIKTGLS*" /label="yrhP CDS" gene complement(2274456..2275088) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /label="yrhP gene" downshifts complement(2274512) /Source="Nicolas_upshifts" /id="D1384" /incds=0 /nref=4 /ntot=132 /MaxReadThrough="4.46187" /MaxDrop="3.11632" /score="37.881034" /energy="-13" /TU="U2084" /idTUdmin="U2084" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2275142..2275161) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2275153) /Source="Nicolas_upshifts" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2275167..2275173 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2275176..2275183) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2275187..2275206 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2275192 /Source="Nicolas_upshifts" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="upshifts" CDS 2275241..2276068 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator controlling amino acid export" /protein_id="NP_390589.1" /db_xref="EnsemblGenomes-Gn:BSU27110" /db_xref="EnsemblGenomes-Tr:CAB14653" /db_xref="InterPro:IPR002831" /db_xref="InterPro:IPR021586" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12303" /db_xref="UniProtKB/Swiss-Prot:O05405" /translation="MKENMLDILKNLNFTEYESKAYLALLQESPLTGYAVAKKSGVPR SKIYEVLESLVIRGDVFVSHGNTPQYVPVPAKELIKNRRLKAEEHFDQAEKYFEKFEQ TANDRENIWNITGRSEILEKVKACILSAKKRILLEIWKEDFKEIEAELKQAAEQGVIV TIIAYGDIVSDFANVYLHDMSSEITEEYDGRWLVYSGDDSEVVAGIVSLGNDSRAAWT MHVGLVMPITEVIIHDLYLMEILKKHRELLEESFGKNLIQLRRKFSIHSDFKKHYLE* " /label="yrhO CDS" gene 2275241..2276068 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /label="yrhO gene" downshifts 2276064 /Source="Nicolas_upshifts" /id="D1385" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="0.74814" /MaxDrop="5.12635" /score="6.64108595" /energy="-9.5" /TU="NA" /idTUdmin="U2085" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2276181..2276190 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2276203..2276218 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2276208 /Source="Nicolas_upshifts" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="upshifts" CDS 2276264..2276764 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 21926231, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 21926231, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma(V))" /protein_id="NP_390590.1" /db_xref="EnsemblGenomes-Gn:BSU27120" /db_xref="EnsemblGenomes-Tr:CAB14654" /db_xref="GOA:O05404" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11974" /db_xref="UniProtKB/Swiss-Prot:O05404" /translation="MKKKQTTKALLVTCITDHKQDFYRLAFSYVKNQDDALDIVQESI KKALSSVETVRNPETIKSWFYKILVRTAIDFLRKQKKIRVMDDETIEFLSKGKEDHYK DTDLHEALDELPYRYKTIIILRFFEDLKLEEIAEITGENTNTVKTRLYRALKLMRIQL TKEDLS*" /label="sigV CDS" gene 2276264..2276764 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /label="sigV gene" CDS 2276764..2277621 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(V) factor" /protein_id="NP_390591.1" /db_xref="EnsemblGenomes-Gn:BSU27130" /db_xref="EnsemblGenomes-Tr:CAB14655" /db_xref="GOA:O05403" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="PDB:5JEN" /db_xref="SubtiList:BG12302" /db_xref="UniProtKB/Swiss-Prot:O05403" /translation="MDKRLQQLREEYKNVQIPKELDIIVEKALQQEPKKKRIVMWPTS AAIAAAILFTALVNINPDAAQAMSKIPVIGKIVKAITFIEIKEEKDQSSIDVKTPALS GLSNKELENSINEKYLKESQQLYKEFIQSTSKNKKGHLSIYSDYETVTDTPDLLSIRR NIETTQASSYTQSRYITIDKKNDILLTLKSLFKDERYIKVISQNIKEQMKQQMKEDPN KIYWLTDEDAEPFKTILPDQTFYITEDHKLVISFDEYEVAPGYMGVTEFTIPTGVISN LLVGERYIR*" /label="rsiV CDS" gene 2276764..2277621 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /label="rsiV gene" promotor_-10 complement(2277639..2277650) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2277658) /Source="Nicolas_upshifts" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2277665..2277671) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2277732..2279636 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1521192, 15661003, 21135105, 21586574, 21856855, 21926231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1521192, 15661003, 21135105, 21586574, 21856855, 21926231; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan O-acetyltransferase" /protein_id="NP_390592.1" /db_xref="EnsemblGenomes-Gn:BSU27140" /db_xref="EnsemblGenomes-Tr:CAB14656" /db_xref="GOA:O05402" /db_xref="InterPro:IPR002656" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12301" /db_xref="UniProtKB/Swiss-Prot:O05402" /translation="MYHKTQHHRYIPGLDGLRAFAVLSVITYHLNFNWANGGFIGVDI FFVLSGYLITSILLPAYGNDINLDFRDFWVRRIRRLLPAAYLMIFSTVVWVVLFDREL LHTVRGDAISSLFYMSNWWFIFHKLSYFDSFGSPSPLKNLWSLAIEEQFYIIWPMFLV VGMYIMKSRARLAAVISLLVLCSAVMMSVLYEPGGDPSRVYYGTDTRSFELLIGCALA LVWPMKRLSSNRLPSKLKHTLHATEFLAFCILVLCVYFTDEYEPFLYRGGMLFISVTA AILIACVCHPSSFLGNLLSWRPLRWLGTRSYGIYLWHYPVIVLSTPVQEIGNPVFWHI VLKVIVTCILAELSYHFIEKPIRTQGFRSFSRRVFIHRIKEWKTTSVISKMSIGFIIF AILIFAGGLSGLAGEQKHPTKWTYSSQETNADTSQASGDKKNAAADKKHNPEQKTTDS NQGQKENKDSGQETHKKKDTQSQQLKKPADTAKEVLAIGDSVMLDISSHLRQSFSNVT IDGKVGRQMSQALELAREYKSFNQPNKAVIIELGTNGYFTNSQIEQLLQSFSKAHIYL VNTRVPRQWESKVNESLQQQAHAHQNVTLVDWHTEALQHPEYFTPDGVHLVPKGAKTL TALIVQAMKS*" /label="oatA CDS" gene 2277732..2279636 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /label="oatA gene" promotor_-35 2279717..2279723 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2279739..2279757 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2279745 /Source="Nicolas_upshifts" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="upshifts" CDS 2279770..2280060 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390593.1" /db_xref="EnsemblGenomes-Gn:BSU27150" /db_xref="EnsemblGenomes-Tr:CAB14657" /db_xref="GOA:O05401" /db_xref="InterPro:IPR025424" /db_xref="SubtiList:BG12300" /db_xref="UniProtKB/Swiss-Prot:O05401" /translation="MKGNEEHDIQKELKRYELFFKKRYKVLYTVNDFIIGAMFLVGSF FFFYDRLMSAGIWLFAIGSLLLLIRPTIRLIHDFHYRKHVEQQFKHQSSTDD*" /label="yrhK CDS" gene 2279770..2280060 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /label="yrhK gene" S_feature 2280061..2280176 /Source="Nicolas_S_feature" /locus_tag="new_2773647_2773762" /HighExp="Etha, Salt, LPhT, HiTm, G135, LBGstat, G180, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1021" promotor_-35 2280158..2280165 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2280178..2280303 /Source="Nicolas_S_feature" /locus_tag="new_2773764_2773889" /HighExp="Gly, G/S, Lbstat, C90, Pyr, LPhT, LoTm, Etha, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1022" upshifts 2280178 /Source="Nicolas_upshifts" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2280179..2280197 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2280197..2280297 /gene="surF" /locus_tag="BSU_misc_RNA_82" /product="small untranslated RNA expressed under sporulation conditions (SurF-AbrB)" /experiment="publication(s) with functional evidences, PMID:20709900, 25790031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 25790031; Product type n: RNA" /label="surF RNA" gene 2280197..2280297 /gene="surF" /locus_tag="BSU_misc_RNA_82" /label="surF gene" downshifts 2280260 /Source="Nicolas_upshifts" /id="D1386" /incds=0 /nref=7 /ntot=129 /MaxReadThrough="3.60641" /MaxDrop="5.24336" /score="25.0079309" /energy="-15.8" /TU="U2089" /idTUdmin="U2088" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS complement(2280304..2283468) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /EC_number="1.14.14.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11574077, 12775685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077, 12775685; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP102A3" /protein_id="NP_390594.1" /db_xref="EnsemblGenomes-Gn:BSU27160" /db_xref="EnsemblGenomes-Tr:CAB14658" /db_xref="GOA:O08336" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12299" /db_xref="UniProtKB/Swiss-Prot:O08336" /translation="MKQASAIPQPKTYGPLKNLPHLEKEQLSQSLWRIADELGPIFRF DFPGVSSVFVSGHNLVAEVCDEKRFDKNLGKGLQKVREFGGDGLFTSWTHEPNWQKAH RILLPSFSQKAMKGYHSMMLDIATQLIQKWSRLNPNEEIDVADDMTRLTLDTIGLCGF NYRFNSFYRDSQHPFITSMLRALKEAMNQSKRLGLQDKMMVKTKLQFQKDIEVMNSLV DRMIAERKANPDENIKDLLSLMLYAKDPVTGETLDDENIRYQIITFLIAGHETTSGLL SFAIYCLLTHPEKLKKAQEEADRVLTDDTPEYKQIQQLKYIRMVLNETLRLYPTAPAF SLYAKEDTVLGGEYPISKGQPVTVLIPKLHRDQNAWGPDAEDFRPERFEDPSSIPHHA YKPFGNGQRACIGMQFALQEATMVLGLVLKHFELINHTGYELKIKEALTIKPDDFKIT VKPRKTAAINVQRKEQADIKAETKPKETKPKHGTPLLVLFGSNLGTAEGIAGELAAQG RQMGFTAETAPLDDYIGKLPEEGAVVIVTASYNGAPPDNAAGFVEWLKELEEGQLKGV SYAVFGCGNRSWASTYQRIPRLIDDMMKAKGASRLTAIGEGDAADDFESHRESWENRF WKETMDAFDINEIAQKEDRPSLSITFLSEATETPVAKAYGAFEGIVLENRELQTAAST RSTRHIELEIPAGKTYKEGDHIGILPKNSRELVQRVLSRFGLQSNHVIKVSGSAHMAH LPMDRPIKVVDLLSSYVELQEPASRLQLRELASYTVCPPHQKELEQLVSDDGIYKEQV LAKRLTMLDFLEDYPACEMPFERFLALLPSLKPRYYSISSSPKVHANIVSMTVGVVKA SAWSGRGEYRGVASNYLAELNTGDAAACFIRTPQSGFQMPNDPETPMIMVGPGTGIAP FRGFIQARSVLKKEGSTLGEALLYFGCRRPDHDDLYREELDQAEQDGLVTIRRCYSRV ENEPKGYVQHLLKQDTQKLMTLIEKGAHIYVCGDGSQMAPDVERTLRLAYEAEKAASQ EESAVWLQKLQDQRRYVKDVWTGM*" /label="cypB CDS" gene complement(2280304..2283468) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /label="cypB gene" downshifts complement(2280320) /Source="Nicolas_upshifts" /id="D1387" /incds=0 /nref=25 /ntot=213 /MaxReadThrough="2.3596" /MaxDrop="4.0425" /score="-9.99429269" /energy="-17.6" /TU="NA" /idTUdmin="U2091" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2281454..2281463 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2281477..2281496 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2281498 /Source="Nicolas_upshifts" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2283484..2284068) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11574077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for cypB" /protein_id="NP_390595.1" /db_xref="EnsemblGenomes-Gn:BSU27170" /db_xref="EnsemblGenomes-Tr:CAB14659" /db_xref="GOA:O08335" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR032551" /db_xref="SubtiList:BG12298" /db_xref="UniProtKB/Swiss-Prot:O08335" /translation="MISASSSKYDMIMKASVSLFTERGFDATTIPMIAERAHVGTGTI YRYFDSKETLVNVLFQESIQRFTEKLKQDVSELPVREGFHHVFCCLVQFTKESDYALF FLETKKDAHYLNHTSKKMIENLTQMLDDYFNKGKAEGVIRSLPSNVLIAIVLGAFLKI YQLVQTGDIEMDTDLITELEQCCWDAIKLHSSQK*" /label="bscR CDS" gene complement(2283484..2284068) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /label="bscR gene" CDS complement(2284291..2284833) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390596.1" /db_xref="EnsemblGenomes-Gn:BSU27180" /db_xref="EnsemblGenomes-Tr:CAB14660" /db_xref="GOA:O05400" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12297" /db_xref="UniProtKB/Swiss-Prot:O05400" /translation="MLENRLYKRSDFWKLFSRKYKLTKTIEHMMIDSIDIQENDRILE IGIGNGTVFKSITKKLKKGSLKSIDPSKRKVRQISRANRKNMGNGEVFHGYPEDIPFD DRTFNKVFSLHTVQSCTDIRLALREIYRVLQIDGRFYISIDTNTGEKEKTYIQLLKDQ HFRDLSVIRRASCLCIVAVK*" /label="yrhH CDS" gene complement(2284291..2284833) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /label="yrhH gene" S_feature complement(2284834..2284919) /Source="Nicolas_S_feature" /locus_tag="new_2778420_2778505_c" /HighExp="T-0.40H, Salt, T0.30H, Heat, T0.0H, Etha, T-1.10H, T-1.40H, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1023" promotor_-10 complement(2284917..2284932) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2284919) /Source="Nicolas_upshifts" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2284945..2284954) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2284988..2285204) /Source="Nicolas_S_feature" /locus_tag="new_2778574_2778790_c" /HighExp="S7, S8, S6, LPhT, BT, LBGstat, S5, B36, G/S, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99909999999999999" /TUshortSig="SigK, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1024" CDS complement(2285022..2285180) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513991.1" /translation="MMNDYQKRLPSIGHGYASMPHSFKHGYGNPFRQQRLMAMQQQRL YVFPYHWH*" /label="hypothetical protein CDS" gene complement(2285022..2285180) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /label="gene" downshifts complement(2285031) /Source="Nicolas_upshifts" /id="D1388" /incds=0 /nref=34 /ntot=184 /MaxReadThrough="3.04168" /MaxDrop="7.65849" /score="23.6695072" /energy="-11.3" /TU="U2093" /idTUdmin="U2092" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2285202..2285221) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2285204) /Source="Nicolas_upshifts" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2285206..2285336) /Source="Nicolas_S_feature" /locus_tag="new_2778792_2778922_c" /HighExp="S7, S8, LPhT, S6, LBGstat, B36, BT, S5, Cold, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.893648" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1025" promotor_-35 complement(2285235..2285244) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2285337..2285486) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390597.1" /db_xref="EnsemblGenomes-Gn:BSU27190" /db_xref="EnsemblGenomes-Tr:CAB14661" /db_xref="InterPro:IPR012655" /db_xref="SubtiList:BG13819" /db_xref="UniProtKB/Swiss-Prot:O32027" /translation="MTINLFFLTLTIKKRFKSLEEFEREQQIEQIYDEMKESQLKHLY LTNWR*" /label="yrzI CDS" gene complement(2285337..2285486) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /label="yrzI gene" downshifts 2285480 /Source="Nicolas_upshifts" /id="D1389" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="1.96539" /MaxDrop="3.70444" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=4972 /isTUend="FALSE" /label="downshifts" S_feature complement(2285487..2285577) /Source="Nicolas_S_feature" /locus_tag="new_2779073_2779163_c" /HighExp="S7, LBGstat, Cold, S6, B36, LPhT, T-0.40H, LoTm, S8, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1026" S_feature complement(2285579..2285798) /Source="Nicolas_S_feature" /locus_tag="new_2779165_2779384_c" /HighExp="B60, B36, S7, BT, LBGstat, Cold, LoTm, LPhT, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52109300000000003" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1027" downshifts complement(2285622) /Source="Nicolas_upshifts" /id="D1390" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="7.23426" /MaxDrop="3.6023" /score="11.9275075" /energy="-19.6" /TU="U2093,U2094" /idTUdmin="U2094" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" downshifts 2285744 /Source="Nicolas_upshifts" /id="D1391" /incds=0 /nref=16 /ntot=94 /MaxReadThrough="0.94778" /MaxDrop="4.28987" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=5236 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2285777..2285796) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2285798) /Source="Nicolas_upshifts" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2285800..2285875) /Source="Nicolas_S_feature" /locus_tag="new_2779386_2779461_c" /HighExp="Lbexp, dia0, dia5, G150, Cold, C30, Mt0, LBGexp, dia15, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115567" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1028" promotor_-35 complement(2285811..2285818) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2285876..2286676) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 24887098; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative formate/nitrite transporter" /protein_id="NP_390598.1" /db_xref="EnsemblGenomes-Gn:BSU27200" /db_xref="EnsemblGenomes-Tr:CAB14662" /db_xref="GOA:O05399" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG12296" /db_xref="UniProtKB/Swiss-Prot:O05399" /translation="MAFRKPDEIAEAAIEAGMKKIKLPLPSLLVLGFLGGAFIALGYL LDIRVIGDLPKEWGSLSSLIGAAVFPVGLILVVLAGAELITGNMMSVAMALFSRKISV KELAINWGIVTIMNLIGALFVAYFFGHLVGLTETGPYLEKTIAVAQGKLDMSFGKVLI SAIGCNWLVCLAVWLSFGAQDAAGKILGIWFPIMAFVAIGFQHVVANMFVIPAAIFAG SFTWGQFIGNIIPAFIGNVIGGAVFVGLIYFIAYHKKDRSRKEMKQVS*" /label="yrhG CDS" gene complement(2285876..2286676) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /label="yrhG gene" S_feature complement(2286745..2286898) /Source="Nicolas_S_feature" /locus_tag="new_2780331_2780484_c" /HighExp="Lbexp, dia0, dia5, Cold, G150, Etha, HiOs, Salt, C90, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1029" downshifts complement(2286788) /Source="Nicolas_upshifts" /id="D1392" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="6.01922" /MaxDrop="3.7673" /score="23.461824" /energy="-25" /TU="U2094,U2095" /idTUdmin="U2095" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2286889..2286908) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-10" upshifts complement(2286898) /Source="Nicolas_upshifts" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="upshifts" promotor_-35 complement(2286923..2286929) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-35" CDS complement(2286939..2287307) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390599.1" /db_xref="EnsemblGenomes-Gn:BSU27210" /db_xref="EnsemblGenomes-Tr:CAB14663" /db_xref="InterPro:IPR018745" /db_xref="SubtiList:BG12295" /db_xref="UniProtKB/Swiss-Prot:O05398" /translation="MSKKIHEFNDIIRKLRKELFGKGPERIHTVFVENMAVSTLYGNL SASEQFIARTPEGREMVHAARTSLIQDLYSKQTPEGMEELMGAKLVHLFSDIKIEENI AVSVFVFDRKIDEQKEALQS*" /label="yrhF CDS" gene complement(2286939..2287307) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /label="yrhF gene" S_feature complement(2287308..2287404) /Source="Nicolas_S_feature" /locus_tag="new_2780894_2780990_c" /HighExp="T0.30H, LBGstat, T1.0H, T1.30H, G150, Lbexp, dia0, G180, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1030" promotor_-10 complement(2287390..2287409) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-10" promotor_-35 2287394..2287397 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2287410) /Source="Nicolas_upshifts" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="upshifts" promotor_-10 2287413..2287432 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2287415 /Source="Nicolas_upshifts" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="upshifts" S_feature 2287416..2287622 /Source="Nicolas_S_feature" /locus_tag="new_2781002_2781208" /HighExp="G150, Lbexp, dia0, Cold, dia5, G135, LBGstat, LBGexp, G180, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1031" promotor_-35 complement(2287425..2287429) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-35" CDS 2287623..2290565 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /EC_number="1.17.1.9" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913079, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative formate dehydrogenase" /protein_id="NP_390600.1" /db_xref="EnsemblGenomes-Gn:BSU27220" /db_xref="EnsemblGenomes-Tr:CAB14664" /db_xref="GOA:Q795Y4" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG12294" /db_xref="UniProtKB/Swiss-Prot:Q795Y4" /translation="MMDVKSISVRVDGTEIQARAGATILDILNENGIEYPQICHVPEV DPIQTCDTCIVEANGKLVRSCATVAENGMSIDLSGNRVKEAQTEAMDRLLENHLLYCT VCDNNNGNCTLHNTAEMMGIEHQKYPYTPKEDPSCAVDMSHPFYRYDPNQCIACGQCV EVCQNLQVNETLSIDWERERPRVIWDEGVPINESSCVSCGQCVTVCPCNALMEKSMLG QAGFMTGIKEDVMEPMIDLVKNVEPGYGSIFAISEVEAAMRETRTKKTKTVCTFCGVG CSFEVWTKGRDILKIQPVSDAPVNAISTCVKGKFGWDFVNSKERITKPLIRKNGAFVE SSWEEALDLVASRLGSIKEQYGKGSVGFISSSKITNEENYVIQKLARQVFETNNVDNC SRYCQSPATDGLFRTVGMGGDAGTIKDIAKAGLVIIVGANPAEGHPVLATRVKRAHKL HGQKLIVADLRKNEMAERSDLFISPKQGTDQVWLMAVTKYMIDQGWHDQAFIDENVNY FEDYKETLKTYTLDYAERITGLSKENIIQIAEMIRDADGTCVLWGMGVTQNTGGSDTS AAISNLLLATGNYRRPGAGAYPLRGHNNVQGACDMGTLPGWLPGYQHITDDKARAKFE EAYGVEIDGKPGLDNIQMLHAIEEGKMKAMYLVGEDMALVDSNANHVHDILSSLDFFV VQDIFLSRTAQYADVVLPATPSLEKDGTFTNTERRVQRLYQALPTLGDAKPDWWIIQE VANRLGANWNYSHPSDIFSEMASLSPLFAKASYEVLEGWNSFLWGSFTGESTPLLYED GFNFPDKKARFALSDWTEPAAFPEEYDLHINNGRMLEHFHEGNMTNKSKGIQAKVPNV FVEISPELAQERGVCDGSLVRLVSPFGAVKLNALITDRVRKNELYLPMNSTDKESAIN FLTGPAADKRTNTPAYKQTKVRMEVLGGCETAPLPKTNPRNKKRHPQNGVEAERKWNR PGYVHLTD*" /label="yrhE CDS" gene 2287623..2290565 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /label="yrhE gene" CDS 2290584..2291066 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10913079" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390601.1" /db_xref="EnsemblGenomes-Gn:BSU27230" /db_xref="EnsemblGenomes-Tr:CAB14665" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG12293" /db_xref="UniProtKB/Swiss-Prot:O05396" /translation="MATPITTIKKETKTAEQIKLEKIEELKELLAENEDAVSKTMTLM NELNDLGIFDAATSMLRAKEDIAKIALGQVSREPVTNLINTMMAAGGALTKADPEFTA KLLESVMAGTEQAQSFLKEDKKVGILDLLKAMNDPDINRAVGFGLQFLKGMGKELREQ *" /label="yrhD CDS" gene 2290584..2291066 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /label="yrhD gene" downshifts 2291046 /Source="Nicolas_upshifts" /id="D1393" /incds=0 /nref=65 /ntot=196 /MaxReadThrough="1.1227" /MaxDrop="6.19465" /score="27.8496451" /energy="-11.2" /TU="NA" /idTUdmin="U2096" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2291102..2291332) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17056751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390602.1" /db_xref="EnsemblGenomes-Gn:BSU27240" /db_xref="EnsemblGenomes-Tr:CAB14666" /db_xref="GOA:O05395" /db_xref="InterPro:IPR025418" /db_xref="SubtiList:BG12292" /db_xref="UniProtKB/Swiss-Prot:O05395" /translation="MNKNRMKSLKEDYKHFAFTLLAVSTFLYIGAVLPDQGLTLGQKS TMFLADCVFLAGAFFCADRSLIYKKRLEEADE*" /label="yrhC CDS" gene complement(2291102..2291332) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /label="yrhC gene" downshifts complement(2291122) /Source="Nicolas_upshifts" /id="D1394" /incds=0 /nref=60 /ntot=210 /MaxReadThrough="0.98344" /MaxDrop="5.84379" /score="15.2557797" /energy="-11.2" /TU="NA" /idTUdmin="U2097" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2291333..2291414) /Source="Nicolas_S_feature" /locus_tag="new_2784919_2785000_c" /HighExp="dia5, dia15, BT, Diami, B36, B60, nit, dia0, MG 10, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1032" CDS complement(2291415..2292554) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /EC_number="4.4.1.2" /EC_number="4.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-lyase and homocysteine gamma-lyase for reverse transsulfuration pathway" /protein_id="NP_390603.1" /db_xref="EnsemblGenomes-Gn:BSU27250" /db_xref="EnsemblGenomes-Tr:CAB14667" /db_xref="GOA:O05394" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12291" /db_xref="UniProtKB/Swiss-Prot:O05394" /translation="MKKKTLMIHGGITGDEKTGAVSVPIYQVSTYKQPKAGQHTGYEY SRTANPTRTALEALVTELESGEAGYAFSSGMAAITAVMMLFNSGDHVVLTDDVYGGTY RVMTKVLNRLGIESTFVDTSSREEVEKAIRPNTKAIYIETPTNPLLKITDLTLMADIA KKAGVLLIVDNTFNTPYFQQPLTLGADIVLHSATKYLGGHSDVVGGLVVTASKELGEE LHFVQNSTGGVLGPQDSWLLMRGIKTLGLRMEAIDQNARKIASFLENHPAVQTLYYPG SSNHPGHELAKTQGAGFGGMISFDIGSEERVDAFLGNLKLFTIAESLGAVESLISVPA RMTHASIPRERRLELGITDGLIRISVGIEDAEDLLEDIGQALENI*" /label="mccB CDS" gene complement(2291415..2292554) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /label="mccB gene" CDS complement(2292556..2293479) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /EC_number="2.5.1.47" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-synthase for the reverse transsulfuration pathway" /protein_id="NP_390604.1" /db_xref="EnsemblGenomes-Gn:BSU27260" /db_xref="EnsemblGenomes-Tr:CAB14668" /db_xref="GOA:O05393" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG12290" /db_xref="UniProtKB/Swiss-Prot:O05393" /translation="MTVITDITELIGNTPLLRLKNFDVPEGVAVYAKLEMMNPGGSIK DRLGDMLIRDALDSGKVKPGGVIIEATAGNTGIGLALSARKYGLKAIFCVPEHFSREK QQIMQALGASIIHTPRQDGMQGAIQKAIQLETEIENSYCVLQFKNRVNPSTYYKTLGP EMWEALDGNIHTFVAGAGSGGTFAGTASFLKEKNPAVKTVIVEPVGSILNGGEPHAHK TEGIGMEFIPDYMDKSHFDEIYTVTDENAFRLVKEAAEKEGLLIGSSSGAALYAALEE AKKASAGTNIVTVFPDSSDRYISKQIYEGGI*" /label="mccA CDS" gene complement(2292556..2293479) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /label="mccA gene" downshifts complement(2293472) /Source="Nicolas_upshifts" /id="D1395" /incds=0 /nref=16 /ntot=178 /MaxReadThrough="7.13056" /MaxDrop="3.40819" /score="0.994445584" /energy="-8.7" /TU="U2097,U2098,U2099" /idTUdmin="U2102" /TUdmin=1874 /isTUend="FALSE" /label="downshifts" S_feature complement(2293480..2293543) /Source="Nicolas_S_feature" /locus_tag="new_2787066_2787129_c" /HighExp="dia5, Diami, dia15, BT, B36, S6, LBGstat, S8, dia0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1033" CDS complement(2293544..2294239) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /EC_number="3.2.2.9" /EC_number="3.2.2.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioadenosine / S-adenosylhomocysteine nucleosidase" /protein_id="NP_390605.1" /db_xref="EnsemblGenomes-Gn:BSU27270" /db_xref="EnsemblGenomes-Tr:CAB14669" /db_xref="GOA:O32028" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR010049" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG13800" /db_xref="UniProtKB/Swiss-Prot:O32028" /translation="MRLAVIGAMEEEVTILRNKLENAKTETIAHCEFTTGEYEGTEVI LLKSGIGKVNAAISTTLLLDRYKPDYVINTGSAGGFHHTLNVGDVVISTDVRHHDVDV TAFDYEYGQVPGLPAAYAADEKLISITEEAVSELDGIQVAKGTIATGDSFMNDPKRVE EVRARFSDLYAVEMEAAAVAQVCHQFKTPFVVIRALSDIAGKESHVSFDQFLEQAAVH STELVLKVIKRIH*" /label="mtnN CDS" gene complement(2293544..2294239) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /label="mtnN gene" promotor_-10 complement(2293979..2293998) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2293997) /Source="Nicolas_upshifts" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2294011..2294020) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2294260..2294901) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 17056751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_390606.1" /db_xref="EnsemblGenomes-Gn:BSU27280" /db_xref="EnsemblGenomes-Tr:CAB14670" /db_xref="GOA:O32029" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023553" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13799" /db_xref="UniProtKB/Swiss-Prot:O32029" /translation="MGREFIPLFEDWAATYDQTVQGLDIQYKEAFRGYDHILDAIVRK SGTHVLEFGPGTGNLTAKLLDAGKTVFGIEPSPAMRKLASDKLSGRTEIVDGDFLTFP EPPFQADTIVSSYAFHHLTDEEKRAAIKQYGKYLHLHDKIVFADTVFENAQAYQQAID KARSQGFYQLANDLETEHYPTLDALKEMFTAEGFAVRFTQQNDFVWIMEAIKR*" /label="yrrT CDS" gene complement(2294260..2294901) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /label="yrrT gene" promotor_-10 complement(2294468..2294487) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2294487) /Source="Nicolas_upshifts" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2294504..2294507) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2294953..2294962 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2294959..2294978) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2294965) /Source="Nicolas_upshifts" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2294975..2294994 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2294984..2295048 /Source="Nicolas_S_feature" /locus_tag="new_2788570_2788634" /HighExp="BT, S6, S7, S8, S5, B36, G/S, Pyr, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1034" upshifts 2294984 /Source="Nicolas_upshifts" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2294994..2294997) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2295029..2295036 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2295050 /Source="Nicolas_upshifts" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2295052..2295069 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2295094..2295297 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390607.1" /db_xref="EnsemblGenomes-Gn:BSU27290" /db_xref="EnsemblGenomes-Tr:CAB14671" /db_xref="InterPro:IPR019686" /db_xref="SubtiList:BG13811" /db_xref="UniProtKB/Swiss-Prot:O32030" /translation="MNFQLDLIKDKVEFFEAASLQELEKKINTQIENNKAIMLRVKSV SHQTLVAEGRILYSAVVHFSAEA*" /label="yrzA CDS" gene 2295094..2295297 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /label="yrzA gene" downshifts 2295304 /Source="Nicolas_upshifts" /id="D1396" /incds=0 /nref=205 /ntot=257 /MaxReadThrough="1.11529" /MaxDrop="5.39095" /score="26.0850303" /energy="-14.2" /TU="NA" /idTUdmin="U2101" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(2295334..2296035) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679248" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390608.1" /db_xref="EnsemblGenomes-Gn:BSU27300" /db_xref="EnsemblGenomes-Tr:CAB14672" /db_xref="GOA:O32031" /db_xref="InterPro:IPR009988" /db_xref="SubtiList:BG13798" /db_xref="UniProtKB/Swiss-Prot:O32031" /translation="MSNNQSRYENRDKRRKANLVLNILIAIVSILIVVVAANLFINSP SSKDVSKDSETAQKQESPASGKTEKKSDEDIKDSKKDTSDSEKDSEKSSDSDSKKDDS SSKKDDSDSDSSSDSAGDGLKDAKVTEGGSSSDVEKTYENPDWKAVGTEQTGEHAATY DSSSQDWAEMLKAISYATGVSTDNMTVLWLGNNGSPQDAKGKILDKATGNKYQVTITW VDEKGWKPTKVEKLK*" /label="yrrS CDS" gene complement(2295334..2296035) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /label="yrrS gene" downshifts complement(2295346) /Source="Nicolas_upshifts" /id="D1397" /incds=0 /nref=237 /ntot=265 /MaxReadThrough="1.64695" /MaxDrop="6.48551" /score="22.1367505" /energy="-14.2" /TU="NA" /idTUdmin="U2102" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2296100..2297854) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14679248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein PBP4B" /protein_id="NP_390609.1" /db_xref="EnsemblGenomes-Gn:BSU27310" /db_xref="EnsemblGenomes-Tr:CAB14673" /db_xref="GOA:O32032" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13797" /db_xref="UniProtKB/Swiss-Prot:O32032" /translation="MKISKRMKLAVIAFLIVFFLLLLRLAEIQLFFTESFSKKKINLI QESVKQRTEEVLISDGRGSFLDRNGRALTGQSEPAVVLFPFLLTQDWPIKKVADILGM SEDDLRQTLGQAKKPVILQQKKIKTLSKQSITKINSLKYPGIYGVYMENEDKPSLASH TIGSTNQDPALLRKKYPDKESLPITTEIGTTGLERTFDEFLLPEQDTKLLYHVDGKGN PLFGMDVKYTAEANTFYPLQIKTTIDQSIQKAMEEVLDEQGLKKGGAVLLDIENSSVL GIVSKPDADVSRQNTLQNYMLTPIYPGSVFKTVIAAAAIENNMVKPSQTFNCNLNLYG EPGDDKGTLSFDESFAQSCNYTFTSLAEQLMKKDSSVIEDMSEKLALTDRAGWEGKLY HETDFRQLYNEKSGVIWGDEKDKSVKKAIAQTAIGQKNVKVTPLEVANMMATIARGGE KRQVKIAEQIEYKNGTTLVTFKDQKLKGETIDKYTSQQLQKILRRVVESPSGTGRRFQ DLPYTVAGKSGTAQTGKLSKEKETLYEKWFAGYFPADKPKYALVVLHMDTPGDKALTN SVFYDIVKKVHEIEINQK*" /label="pbpI CDS" gene complement(2296100..2297854) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /label="pbpI gene" misc_feature complement(2296128..2296147) /Source="Nicolas_upshift_promotors" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2296138) /Source="Nicolas_upshifts" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2297169..2297184) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2297172) /Source="Nicolas_upshifts" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2297197..2297206) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2297400..2297418) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2297414) /Source="Nicolas_upshifts" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2297433..2297440 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2297433..2297438) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2297455..2297474 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2297460 /Source="Nicolas_upshifts" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2297908..2298381) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10910724, 16014871, 16707701, 21515770, 28976965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10910724, 16014871, 16707701, 21515770, 28976965; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription elongation factor resolving backtracking / stalling" /protein_id="NP_390610.1" /db_xref="EnsemblGenomes-Gn:BSU27320" /db_xref="EnsemblGenomes-Tr:CAB14674" /db_xref="GOA:P80240" /db_xref="InterPro:IPR001437" /db_xref="InterPro:IPR006359" /db_xref="InterPro:IPR018151" /db_xref="InterPro:IPR022691" /db_xref="InterPro:IPR023459" /db_xref="InterPro:IPR028624" /db_xref="InterPro:IPR036805" /db_xref="InterPro:IPR036953" /db_xref="SubtiList:BG19019" /db_xref="UniProtKB/Swiss-Prot:P80240" /translation="MAQEKVFPMTAEGKQKLEQELEYLKTVKRKEVVERIKIARSFGD LSENSEYDSAKEEQAFVEGRVTTLENMIRNAKIIEDDGGSNVVGLGKTVTFVELPDGD EESYTIVGSAEADPFEGKISNDSPIAKSLLGKKVDEEVTVQTPGGEMLVKIVKIS*" /label="greA CDS" gene complement(2297908..2298381) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /label="greA gene" downshifts complement(2297915) /Source="Nicolas_upshifts" /id="D1398" /incds=0 /nref=130 /ntot=229 /MaxReadThrough="5.30316" /MaxDrop="4.90519" /score="34.2316821" /energy="-17" /TU="U2107" /idTUdmin="U2106" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" S_feature complement(2298382..2298514) /Source="Nicolas_S_feature" /locus_tag="new_2791968_2792100_c" /HighExp="HPh, C90, dia5, dia15, Diami, H2O2, dia0, Etha, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1035" promotor_-10 complement(2298496..2298515) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2298514) /Source="Nicolas_upshifts" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2298516..2298624) /Source="Nicolas_S_feature" /locus_tag="new_2792102_2792210_c" /HighExp="HPh, G180, G135, LBGexp, dia0, Paraq, Oxctl, G150, LPh, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1036" promotor_-35 complement(2298529..2298536) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2298617..2298636) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2298624) /Source="Nicolas_upshifts" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2298632..2299267) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /EC_number="2.7.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 6208029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridine kinase" /protein_id="NP_390611.1" /db_xref="EnsemblGenomes-Gn:BSU27330" /db_xref="EnsemblGenomes-Tr:CAB14675" /db_xref="GOA:O32033" /db_xref="InterPro:IPR000764" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR026008" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12696" /db_xref="UniProtKB/Swiss-Prot:O32033" /translation="MGKNPVVIGIAGGSGSGKTSVTRSIYEQFKGHSILMIQQDLYYK DQSHLPFEERLNTNYDHPLAFDNDYLIEHIQDLLNYRPIEKPIYDYKLHTRSEETVHV EPKDVIILEGILVLEDKRLRDLMDIKLYVDTDADLRIIRRIMRDINERGRSIDSVIEQ YVSVVRPMHNQFVEPTKRYADIIIPEGGQNHVAIDLMVTKIQTILEQNAIL*" /label="udk CDS" gene complement(2298632..2299267) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /label="udk gene" promotor_-35 complement(2298652..2298656) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2298762..2298767 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2298783..2298801 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2298790 /Source="Nicolas_upshifts" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2299274..2300542) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase large subunit" /protein_id="NP_390612.1" /db_xref="EnsemblGenomes-Gn:BSU27340" /db_xref="EnsemblGenomes-Tr:CAB14676" /db_xref="GOA:O32034" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032525" /db_xref="SubtiList:BG13796" /db_xref="UniProtKB/Swiss-Prot:O32034" /translation="MTAVNDKISTIVNGKRVITKKPELLAPAGNLEKLKIAVHYGADA VFIGGQEYGLRSNADNFTIEEIAEGVEFAKKYGAKIYVTTNIFAHNENMDGLEDYLKA LGDANVAGIIVADPLIIETCRRVAPNVEVHLSTQQSLSNWKAVQFWKEEGLDRVVLAR ETSALEIREMKEKVDIEIESFIHGAMCIAYSGRCVLSNHMTARDSNRGGCCQSCRWDY DLYQTDGANAVALYGEEDAPFAMSPKDLKLIESIPKMIEMGIDSLKIEGRMKSIHYVA TVVSVYRKVIDAYCADPENFVIQKEWLEELDKCANRDTATAFFEGTPGYEEQMFGEHA KKTTYDFVGLVLNYDEDTQMVTLQQRNFFKKGDEVEFFGPEIENFTHTIETIWDEDGN ELDAARHPLQIVKFKLDKKIYPSNMMRKGK*" /label="yrrO CDS" gene complement(2299274..2300542) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /label="yrrO gene" CDS complement(2300561..2301490) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase small subunit" /protein_id="NP_390613.1" /db_xref="EnsemblGenomes-Gn:BSU27350" /db_xref="EnsemblGenomes-Tr:CAB14677" /db_xref="GOA:O32035" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG13795" /db_xref="UniProtKB/Swiss-Prot:O32035" /translation="MKKPELLVTPTSTADILPLIQAGATAFLVGEQRYGLRLAGEFSR EDVTKAVEIAHKEGAKVYVAVNAIFHNDKVGELGEYLAFLAEAGVDAAVFGDPAVLMA ARESAPDLKLHWSTETTGTNYYTCNYWGRKGAARSVLARELNMDSIVEIKENAEVEIE IQVHGMTCMFQSKRSLIGNYFEYQGKVMDIERKKKESGMFLHDKERDNKYPIFEDENG THIMSPNDVCIIDELEELIDAGIDSFKIDGVLKMPEYLIEVTKMYREAIDLCVENRDE YEAKKEDWIERIESIQPVNRKIDTGFFFKETVY*" /label="yrrN CDS" gene complement(2300561..2301490) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /label="yrrN gene" CDS complement(2301496..2302149) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /EC_number="2.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA O-methyltransferase" /protein_id="NP_390614.1" /db_xref="EnsemblGenomes-Gn:BSU27360" /db_xref="EnsemblGenomes-Tr:CAB14678" /db_xref="GOA:O32036" /db_xref="InterPro:IPR002935" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13794" /db_xref="UniProtKB/Swiss-Prot:O32036" /translation="MTDRYEQINDYIEALLKPRPDNVKRLEAYAEEHHVPIMEKAGME VLLQILSVKQPKKILEIGTAIGYSAIRMALELPSAEIYTIERNEKRHEEAVNNIKEFQ LDDRIHVFYGDALELADAVHVTAPYDVIFIDAAKGQYQNFFHLYEPMLSPDGVIITDN VLFKGLVAEDYSKIEPKRRRRLVAKIDEYNHWLMNHPDYQTAIIPVGDGLAISKKKR* " /label="yrrM CDS" gene complement(2301496..2302149) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /label="yrrM gene" S_feature complement(2302150..2302254) /Source="Nicolas_S_feature" /locus_tag="new_2795736_2795840_c" /HighExp="LBGexp, G180, H2O2, G150, Paraq, Oxctl, G135, dia15, C30, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1037" promotor_-10 complement(2302236..2302255) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2302254) /Source="Nicolas_upshifts" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2302271..2302275) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2302301..2303383) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved membrane associated protein" /protein_id="NP_390615.1" /db_xref="EnsemblGenomes-Gn:BSU27370" /db_xref="EnsemblGenomes-Tr:CAB14679" /db_xref="GOA:O34758" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13793" /db_xref="UniProtKB/Swiss-Prot:O34758" /translation="MYINQQKKSFFNKKRIILSSIVVLFLIIGGAFLYGKSLLEPVEK DSKTTVNINIPSGSSVSAIASILKKNDVIKSEKAFQYYVKYKGASGFQAGFYHLNKGM DLDAIIQKLTSGATGYAFQITVTEGAQLTQIAAAIADETKYSKKQVIAKLDDETFINQ LKKEFPDTVTNDVFNKNIKHPLEGYLFPATYPFNDPDTSLEDIIKAMIKQTNSYVETY KSEMKKNKVSVHKLLTMASLIEEEATEKADRHKIASVFYNRLKKKMPLQTDPTVLYAA GKHKDRVLYKDLEIDSPYNTYKNTGLTPGPIANAGMSSWEAALHPDKTDYLYFLAKSN GEVVFTKTLKEHNKAKEKYISSKNEK*" /label="yrrL CDS" gene complement(2302301..2303383) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /label="yrrL gene" downshifts complement(2302335) /Source="Nicolas_upshifts" /id="D1399" /incds=0 /nref=21 /ntot=144 /MaxReadThrough="3.5258" /MaxDrop="3.97301" /score="10.5327118" /energy="-11" /TU="U2110" /idTUdmin="U2111" /TUdmin=1173 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2303399..2303418) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2303419) /Source="Nicolas_upshifts" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2303433..2303436) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2303509) /Source="Nicolas_upshifts" /id="D1400" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="2.55298" /MaxDrop="6.9121" /score="36.0941054" /energy="-15" /TU="NA" /idTUdmin="U2111" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2303514..2303795) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_390616.1" /db_xref="EnsemblGenomes-Gn:BSU27380" /db_xref="EnsemblGenomes-Tr:CAB14680" /db_xref="InterPro:IPR009711" /db_xref="SubtiList:BG13812" /db_xref="UniProtKB/Swiss-Prot:O34828" /translation="MEHGEKNITIVDDQGNEQLCEVLFTFENEEFGKSYVLYYPIESK DDEEVEILASSFTPNEDGENGELFPIETDEEWDMIEETLNTFLADEDEE*" /label="yrzB CDS" gene complement(2303514..2303795) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /label="yrzB gene" downshifts complement(2303574) /Source="Nicolas_upshifts" /id="D1401" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.68915" /MaxDrop="5.19246" /score="36.0941054" /energy="-15" /TU="U2111,U2113,U2114,U2115" /idTUdmin="U2111" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2303813..2304229) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 14512736, 16021622, 22720735, 23251031, 25545592; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pre-16S ribosomal RNA maturation enzyme" /protein_id="NP_390617.1" /db_xref="EnsemblGenomes-Gn:BSU27390" /db_xref="EnsemblGenomes-Tr:CAB14681" /db_xref="GOA:O34634" /db_xref="InterPro:IPR005227" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR037027" /db_xref="PDB:1VHX" /db_xref="SubtiList:BG13792" /db_xref="UniProtKB/Swiss-Prot:O34634" /translation="MRILGLDLGTKTLGVALSDEMGWTAQGIETIKINEAEGDYGLSR LSELIKDYTIDKIVLGFPKNMNGTVGPRGEASQTFAKVLETTYNVPVVLWDERLTTMA AEKMLIAADVSRQKRKKVIDKMAAVMILQGYLDSLN*" /label="rimF CDS" gene complement(2303813..2304229) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /label="rimF gene" promotor_-10 complement(2304061..2304079) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2304080) /Source="Nicolas_upshifts" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2304095..2304100) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2304237..2304503) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_054589.1" /db_xref="EnsemblGenomes-Gn:BSU27400" /db_xref="EnsemblGenomes-Tr:CAE01464" /db_xref="InterPro:IPR009309" /db_xref="SubtiList:BG14184" /db_xref="UniProtKB/Swiss-Prot:Q7WY61" /translation="MSSFDKTMKFNFSDDSAETNVNEVLITVYDALQEKGYNPINQIV GYLLSGDPAYIPRHRDARNLIRKLERDELIEELVKSYLEQHKEA*" /label="yrzL CDS" gene complement(2304237..2304503) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /label="yrzL gene" promotor_-35 2304391..2304399 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2304414..2304433 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2304422..2305611 /Source="Nicolas_S_feature" /locus_tag="new_2798008_2799197" /HighExp="S6, C30, C90, S8, S7, Gly, G135, Fru, G180, M/G" /AntisenseName="alaS" /AntisenseCor="-0.27843994691040502" /AntisenseRegPval="-5.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1038" upshifts 2304422 /Source="Nicolas_upshifts" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2304504..2304564) /Source="Nicolas_S_feature" /locus_tag="new_2798090_2798150_c" /HighExp="LBGtran, LBGexp, G135, C90, G150, G180, LBGstat, Oxctl, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigA" /TUshortPSig="0.994, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1039" promotor_-10 complement(2304558..2304577) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2304564) /Source="Nicolas_upshifts" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2304588..2307224) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /EC_number="6.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12554667, 12682299, 17329819, 22720735, 25918376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanyl-tRNA synthetase" /protein_id="NP_390618.1" /db_xref="EnsemblGenomes-Gn:BSU27410" /db_xref="EnsemblGenomes-Tr:CAB14682" /db_xref="GOA:O34526" /db_xref="InterPro:IPR002318" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018162" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR018164" /db_xref="InterPro:IPR018165" /db_xref="InterPro:IPR023033" /db_xref="SubtiList:BG12563" /db_xref="UniProtKB/Swiss-Prot:O34526" /translation="MKHLTSAEVRQMFLDFFKEKGHAVEPSASLVPHEDPSLLWINSG VATLKKYFDGRVVPENPRIVNAQKAIRTNDIENVGKTARHHTFFEMLGNFSIGDYFKE EAITWAWEFLTSDKWIGFDKELLSVTVHPEDEEAYEFWAKKIGIPEERIIRLEGNFWD IGEGPSGPNTEIFYDRGEAYGNDPEDPELYPGGENDRYLEVWNLVFSEFNHNPDGTYT PLPKKNIDTGMGLERMVSVIQNVPTNFDTDLFVPIIKATESISGETYGKDNVKDTAFK VIADHIRTVAFAVSDGALPSNEGRGYVLRRLLRRAVRYAKTINIHRPFMFDLVPVVAE IMADFYPEVKEKADFIAKVIKTEEERFHETLNEGLAILSEMIKKEKDKGSSVISGADV FKLYDTYGFPVELTEEYAEDENMTVDHEGFEEEMNQQRERARNARQDVGSMQVQGGAL RDVTVESTFVGYSQTKADANIIVLLQDGQLIEEAHEGESVQIILDETPFYAESGGQIG DKGYLRSEQAVVRIKDVQKAPNGQHVHEGVVESGTVQKGLHVTAEVEDHMRSGVIKNH TATHLLHQALKDVLGTHVNQAGSLVTENRLRFDFSHFGQVTKEELEQIERIVNEKIWA SIPVSIDLKPIAEAKEMGAMALFGEKYGDIVRVVQVGDYSLELCGGCHVRNTAEIGLF KIVSESGIGAGTRRIEAVTGQGAYVEMNSQISVLKQTADELKTNIKEVPKRVAALQAE LKDAQRENESLLAKLGNVEAGAILSKVKEVDGVNVLAAKVNAKDMNHLRTMVDELKAK LGSAVIVLGAVQNDKVNISAGVTKDLIEKGLHAGKLVKQAAEVCGGGGGGRPDMAQAG GKQPEKLEEALASVEDWVKSVL*" /label="alaS CDS" gene complement(2304588..2307224) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /label="alaS gene" promotor_-35 complement(2304591..2304598) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2306990..2307008) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2307006) /Source="Nicolas_upshifts" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2307022..2307029) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2307225..2307303) /Source="Nicolas_S_feature" /locus_tag="new_2800811_2800889_c" /HighExp="G150, LBGexp, G135, G180, Oxctl, LBGtran, Lbexp, Paraq, dia15, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1040" misc_RNA complement(2307304..2307511) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /product="T-box riboswitch specific of alanine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboA RNA" gene complement(2307304..2307511) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /label="tboA gene" promotor_-10 complement(2307519..2307538) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2307534) /Source="Nicolas_upshifts" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2307553..2307560) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2307555..2308616) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_390619.1" /db_xref="EnsemblGenomes-Gn:BSU27420" /db_xref="EnsemblGenomes-Tr:CAB14683" /db_xref="GOA:O34472" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13791" /db_xref="UniProtKB/Swiss-Prot:O34472" /translation="MLQKPVQLLLWVAICLLVLLTVYVFFMLDMLWSPFWLVIKTIFI PLIISIFISYLLLPVTEWLHGKGLPRTLSILVIYVLFFGGIGWALYKGVPVLIVQLTD LSENIPMFAETYNGLLLHVHNHTDDWPDGMHHRIDKMIRQTEAFFAGTIEGAISGIRN VLDYFLIAATIPFLVFYMVKDIELMKKTVWYLTPKSWRKRGSAFLRDVDDSLGDYIRG QLLVCLILGVIAGISFWVFGLPYPLILGLISGVTNVIPYFGPFIGAVPALLIAMTISV KAVLVVVITVFILQFMEGNILSPFIVGRSLKMHPVVIMLALLAGGELAGIVGMILAVP ATAVLKVMMIHFLRMRTEH*" /label="yrrI CDS" gene complement(2307555..2308616) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /label="yrrI gene" promotor_-35 2308525..2308530 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2308536..2308771 /Source="Nicolas_S_feature" /locus_tag="new_2802122_2802357" /HighExp="S5, S6, S4, S8, S3, S7, LoTm, BT, M9-stat, T5.0H" /AntisenseName="yrrI" /AntisenseCor="0.71790030040923003" /AntisenseRegPval="-43.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1041" upshifts 2308537 /Source="Nicolas_upshifts" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2308546..2308564 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2308633..2308644) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2308634) /Source="Nicolas_upshifts" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2308658..2308664) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2308772..2309500 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (ATP-binding protein)" /protein_id="NP_390620.1" /db_xref="EnsemblGenomes-Gn:BSU27430" /db_xref="EnsemblGenomes-Tr:CAB14684" /db_xref="GOA:O34677" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11485" /db_xref="UniProtKB/Swiss-Prot:O34677" /translation="MITFQNVNKHYGDFHVLKQINLQIEKGEVVVIIGPSGSGKSTLL RCINRLESINEGVLTVNGTAINDRKTDINQVRQNIGMVFQHFHLYPHKTVLQNIMLAP VKVLRQSPEQAKETARYYLEKVGIPDKADAYPSQLSGGQQQRVAIARGLAMKPEVMLF DEPTSALDPEMIGEVLDVMKTLAKEGMTMVVVTHEMGFAKEVADRIVFIDEGKILEEA VPAEFYANPKEERARLFLSRILNH*" /label="glnQ CDS" gene 2308772..2309500 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /label="glnQ gene" downshifts complement(2309228) /Source="Nicolas_upshifts" /id="D1402" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="1.29649" /MaxDrop="3.29152" /score="-3.35464926" /energy="-5.4" /TU="NA" /idTUdmin="U2117" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" CDS 2309522..2310343 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (glutamine-binding lipoprotein)" /protein_id="NP_390621.1" /db_xref="EnsemblGenomes-Gn:BSU27440" /db_xref="EnsemblGenomes-Tr:CAB14685" /db_xref="GOA:O34563" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11486" /db_xref="UniProtKB/Swiss-Prot:O34563" /translation="MKKIFSLALISLFAVILLAACGSKGSNGEASKESKKDTLAAIKD NDKIVFGVKTDTRLFGLKNPSSGEIEGFDIDIAKQIAKDILGDEKKAQFKEVTSKTRI PMLQNGDIDAIVATMTITEERKKEVDFSDVYFEAGQSLLVKKGSKIKSVENLGKGSKV LAVKGSTSSQNIREKAPEASVLEFENYAEAFTALKSGQGDALTTDNAILYGMADENKN YQLTGKPFTDEPYGIAVKKGQSALAKEINASLKKMKSDGRYDEIYKKWIKEDPAE*" /label="glnH CDS" gene 2309522..2310343 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /label="glnH gene" CDS 2310404..2311054 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390622.1" /db_xref="EnsemblGenomes-Gn:BSU27450" /db_xref="EnsemblGenomes-Tr:CAB14686" /db_xref="GOA:O34671" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11487" /db_xref="UniProtKB/Swiss-Prot:O34671" /translation="MNVSILFDNFSMYMDGFYHTLLASVIALAGSFVLGVAVAVMRIT VFKPLQWLGTAYVEFIRNIPLLLITFVFYFGLPNAGLRLDGFQAGTVALTIYTSAFIA EAIRAGIQSVSKGQMEAARSSGFTYSQAMLHIILPQAIKIVIPPLGNQFLNLVKNSSI LGVVAGLDLMYQADLVSSSTLVVFDVYIFVALFYLVLTIPLSIGVNYLEKRLEKSY*" /label="glnM CDS" gene 2310404..2311054 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /label="glnM gene" CDS 2311071..2311727 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390623.1" /db_xref="EnsemblGenomes-Gn:BSU27460" /db_xref="EnsemblGenomes-Tr:CAB14687" /db_xref="GOA:O34606" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11488" /db_xref="UniProtKB/Swiss-Prot:O34606" /translation="MDFIGAYSQEHLAFLWDGFLVTLYVAFISIILSFFFGLIAGTLR YAKVPVLSQLIAVLVETIRNLPLLLIIFFTFFALPEIGIKLEITAAAITALTIFESAM LSEIIRSGLKSIDKGQIEAARSSGLSYTQTLFFIVMPQALRRMVPPIVSQFISLLKDT SLAVVIALPELIHNAQIINGQSADGSYFFPIFLLAALMYFAVNYSLSLAARRLEVRQT *" /label="glnP CDS" gene 2311071..2311727 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /label="glnP gene" downshifts 2311726 /Source="Nicolas_upshifts" /id="D1403" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.21558" /MaxDrop="6.08472" /score="5.38937989" /energy="-11.7" /TU="NA" /idTUdmin="U2116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2311762..2311893) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097766.1" /db_xref="EnsemblGenomes-Gn:BSU27468" /db_xref="EnsemblGenomes-Tr:CAX52672" /db_xref="InterPro:IPR025029" /db_xref="UniProtKB/Swiss-Prot:C0H461" /translation="MNRTMTSLLAMGAGALVYRMATQSDMLNNRSMKRMRRRITKMF* " /label="yrzQ CDS" gene complement(2311762..2311893) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /label="yrzQ gene" downshifts complement(2311780) /Source="Nicolas_upshifts" /id="D1404" /incds=0 /nref=50 /ntot=77 /MaxReadThrough="1.58565" /MaxDrop="8.21989" /score="5.69801689" /energy="-11.7" /TU="NA" /idTUdmin="U2118" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2311915..2312106) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097767.1" /db_xref="EnsemblGenomes-Gn:BSU27469" /db_xref="EnsemblGenomes-Tr:CAX52673" /db_xref="UniProtKB/Swiss-Prot:C0H462" /translation="MLICPNCKSKDIGKIGVNQYYCWGCFIELTVAKGKIATHQVEED GTLSSLDDLFSEDERSINF*" /label="yrzR CDS" gene complement(2311915..2312106) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /label="yrzR gene" CDS complement(2312118..2312642) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390624.1" /db_xref="EnsemblGenomes-Gn:BSU27470" /db_xref="EnsemblGenomes-Tr:CAB14688" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13790" /db_xref="UniProtKB/Swiss-Prot:O34402" /translation="MSLRRKAKPKPVQQKVVDHTLRTCHEVEGFPVYSERTSSYLGTI SDICFSLKGDCLGFILAQKRFLHHHHALLRACDISSIFDDRILASVSSEQLLPLPKSC FTYEQMKMKLVKSQEGDILGMLEDVYFCLDRGIIVAYELSDGFFSDLAGSKRQIQRAD SLVEVRKDEIVLNG*" /label="yrrD CDS" gene complement(2312118..2312642) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /label="yrrD gene" upshifts complement(2312229) /Source="Nicolas_upshifts" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2312233..2312244) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2312259..2312265) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2312613..2312624) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2312619) /Source="Nicolas_upshifts" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2312639..2312645) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2312700..2315096) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /EC_number="3.1.11.5" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3537961, 11557815, 21170359, 22720735, 24443534, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3537961, 11557815, 21170359, 22720735, 24443534, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5'-3' helicase associated to SSB; exonuclease V" /protein_id="NP_390625.1" /db_xref="EnsemblGenomes-Gn:BSU27480" /db_xref="EnsemblGenomes-Tr:CAB14689" /db_xref="GOA:O34481" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR006345" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="InterPro:IPR029493" /db_xref="SubtiList:BG13789" /db_xref="UniProtKB/Swiss-Prot:O34481" /translation="MQQHPDQLKLEEEPYLKGTVNTVIYHNDTNLYTVLKVKVTETSE AIEDKAVSVTGYFPALQEEETYTFYGKIVTHPKFGLQFQAEHFKKEIPTTKEGIIQYL SSDLFEGIGKKTAEEIVKKLGDSAINKILADASVLYDVPRLSKKKADTLAGALQRHQG LEQIMISLNQFGFGPQLSMKIYQAYESETLEKIQENPYQLVKDVEGIGFGKADELGSR MGLSGNHPERVKAAILYTLETTCLSEGHTYIETEQLIIDTQSLLNQSAREGQRITEMD AANAIIALGENKDIVIEDGRCYFPSLFYAEQNVAKRVKHIASQTEYENQFPESEFLLA LGELEERMDVQYAPSQKEAIQKALSSPMLLLTGGPGTGKTTVIRGIVELYGELHGVSL DPSAYKKDEAFPIVLAAPTGRAAKRMSESTGLPAVTIHRLLGWNGAEGFTHTEDQPIE GKLLIIDEASMLDIWLANHLFKAIPDHIQIIIVGDEDQLPSVGPGQVLRDLLASQVIP TVRLTDIYRQAEGSSIVELAHQMKNGLLPNNLTAPTKDRSFIRCGGSQIKEVVEKVVA NALKKGYTAKDIQVLAPMYRGKAGINELNVMLQDILNPPKEKRRELKFGDVVYRTGDK ILQLVNQPENNVFNGDIGEITSIFYAKENTEKEDMAVVSFDGNEMTFTKKDFNQFTHA YCCSIHKSQGSEFPIVVLPVVKGYYRMLRRNLLYTAITRAKKFLILCGEEEALEWGVK NNDATVRQTSLKNRLSVQVEEMDAELEALQKELPFSVHDANIGMEGITPFDFMKEEQQ *" /label="recDB CDS" gene complement(2312700..2315096) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /label="recDB gene" downshifts complement(2312726) /Source="Nicolas_upshifts" /id="D1405" /incds=0 /nref=32 /ntot=211 /MaxReadThrough="2.07603" /MaxDrop="3.57113" /score="41.0323102" /energy="-10.8" /TU="NA" /idTUdmin="U2121" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2312946..2312952 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2312960 /Source="Nicolas_upshifts" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2312967..2312978 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2312980..2313329 /Source="Nicolas_S_feature" /locus_tag="new_2806566_2806915" /HighExp="S8, S5, S6, S7, S4, C30, nit, ferm, G135, T5.0H" /AntisenseName="yrrC" /AntisenseCor="-0.46935785055870999" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1042" downshifts complement(2313081) /Source="Nicolas_upshifts" /id="D1406" /incds=1 /nref=16 /ntot=163 /MaxReadThrough="4.93428" /MaxDrop="2.86437" /score="41.0323102" /energy="-10.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-355" /isTUend="FALSE" /label="downshifts" CDS complement(2315121..2315741) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11777911, 12594026, 18180259; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative tetratricopeptide repeat family protein" /protein_id="NP_390626.1" /db_xref="EnsemblGenomes-Gn:BSU27490" /db_xref="EnsemblGenomes-Tr:CAB14690" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR013105" /db_xref="InterPro:IPR019734" /db_xref="PDB:2Q7F" /db_xref="SubtiList:BG13788" /db_xref="UniProtKB/Swiss-Prot:O34452" /translation="MQEGDYEKAAEAFTKAIEENKEDAIPYINFANLLSSVNELERAL AFYDKALELDSSAATAYYGAGNVYVVKEMYKEAKDMFEKALRAGMENGDLFYMLGTVL VKLEQPKLALPYLQRAVELNENDTEARFQFGMCLANEGMLDEALSQFAAVTEQDPGHA DAFYNAGVTYAYKENREKALEMLDKAIDIQPDHMLALHAKKLIDPS*" /label="yrrB CDS" gene complement(2315121..2315741) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /label="yrrB gene" CDS complement(2315827..2316942) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /EC_number="2.8.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-specific 2-thiouridylase" /protein_id="NP_390627.3" /db_xref="EnsemblGenomes-Gn:BSU27500" /db_xref="EnsemblGenomes-Tr:CAB14691" /db_xref="GOA:O35020" /db_xref="InterPro:IPR004506" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023382" /db_xref="SubtiList:BG13787" /db_xref="UniProtKB/Swiss-Prot:O35020" /translation="MEKRPEDTRVVVGMSGGVDSSVAALLLKEQGYDVIGIFMKNWDD TDENGFCTATEDYEDVIRVCNQIGIPYYAVNFEKQYYEKVFQYFLDEYKAGRTPNPDV LCNKEIKFKAFLEHALSLGADYLATGHYARVDRSGGKVRMLRGIDENKDQTYFLNQLT EDTLSKVMFPIGELQKSRVREIAKEAELATATKKDSTGICFIGERNFKTFLSQYLPAQ PGDMMTMDGEVKGRHDGLMYYTIGQRHGLGIGGSGEPWFAVGKDLEKNILYVDQGFHN PLLYSDKITATNISWVRSDIMKGEEISCTAKFRYRQEDHKVTVRMTGEGEAEVIFDEQ VRAVTPGQAVVFYDGEECLGGGTIDDVYKDGTKLWYV*" /label="mnmA CDS" gene complement(2315827..2316942) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /label="mnmA gene" downshifts complement(2315828) /Source="Nicolas_upshifts" /id="D1407" /incds=0 /nref=2 /ntot=69 /MaxReadThrough="6.45399" /MaxDrop="4.31641" /score="2.49091848" /energy="-7.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-3102" /isTUend="FALSE" /label="downshifts" CDS complement(2316973..2318112) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496536, 10930739, 12682299, 17064282, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496536, 10930739, 12682299, 17064282, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase involved in U34 tRNA thiolation" /protein_id="NP_390629.2" /db_xref="EnsemblGenomes-Gn:BSU27510" /db_xref="EnsemblGenomes-Tr:CAB14693" /db_xref="GOA:O34599" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG13809" /db_xref="UniProtKB/Swiss-Prot:O34599" /translation="MERIYLDHAATSPMDERVLEQMIPHFSGSFGNPSSIHSFGRESR KWVDEARAQIAAEIGAAEQEIIFTSGGTEADNLAIMGTALARKDLGRHIITTKIEHHA VLHTCEKLEGDGFDITYLDVDQNGRVSAKQVKEALRDDTILVTVMYGNNEVGTVQPIE EIGELLKEHKAYFHTDAVQAFGLLPIDVKNSHIDLLSVSGHKLNGPKGTGFLYASKDV KLSPLLFGGEQERKRRAGTENVPGIVGLKEAIKLSSEERDEKNEKYQSFKAIFADTLR DAGVAFEVNGDKEHSLPHVLNLYFPGVSVEALLVNLDMAGVAVSSGSACTAGSVLPSH VLTAMFGEESDRLTSSIRISFGLGNTAEQVKTAAKHVADVVKRLT*" /label="iscSA CDS" gene complement(2316973..2318112) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /label="iscSA gene" promotor_-10 complement(2317679..2317698) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2317691) /Source="Nicolas_upshifts" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2317712..2317719) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2318131..2318547) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of cysteine biosynthesis" /protein_id="NP_390630.2" /db_xref="EnsemblGenomes-Gn:BSU27520" /db_xref="EnsemblGenomes-Tr:CAB14694" /db_xref="GOA:O34527" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2Y75" /db_xref="SubtiList:BG13813" /db_xref="UniProtKB/Swiss-Prot:O34527" /translation="MKISTKGRYGLTIMIELAKKHGEGPTSLKSIAQTNNLSEHYLEQ LVSPLRNAGLVKSIRGAYGGYVLGSEPDAITAGDIIRVLEGPISPVEVLEDEEPAKRE LWIRIRDAVKEVLDSTTLEDLASYTDGEQEAYMFYI*" /label="cymR CDS" gene complement(2318131..2318547) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /label="cymR gene" S_feature complement(2318548..2318645) /Source="Nicolas_S_feature" /locus_tag="new_2812134_2812231_c" /HighExp="Cold, T3.0H, G135, LBGexp, G180, G150, Salt, Lbexp, H2O2, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1043" promotor_-10 complement(2318630..2318649) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2318645) /Source="Nicolas_upshifts" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2318665..2318668) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2318693..2318700 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2318714..2318733 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2318722 /Source="Nicolas_upshifts" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="upshifts" CDS 2318750..2320015 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15743409, 17641684, 21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743409, 17641684, 21170359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-dependent ATPase active at replication forks" /protein_id="NP_390631.1" /db_xref="EnsemblGenomes-Gn:BSU27530" /db_xref="EnsemblGenomes-Tr:CAB14695" /db_xref="GOA:O34528" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR021886" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032423" /db_xref="SubtiList:BG13808" /db_xref="UniProtKB/Swiss-Prot:O34528" /translation="MKPLAYRMRPTKIEDIIGQQHLVAEDKIIGRMVQAKHLSSMILY GPPGIGKTSIATAIAGSTSIAFRKLNAVINNKKDMEIVAQEAKMSGQVILILDEVHRL DKGKQDFLLPYLENGMIILIGATTANPYHAINPAIRSRTQIFELEPLTPELIKQALER ALHDEHRGLGTYSVSIDDQAMEHFAHGCGGDVRSALNALELAVLSTKESADGEIHITL ETAEECLQKKSFSHDKDGDAHYDVLSAFQKSIRGSDANAALHYLARLIEAGDLESIAR RLLVIAYEDIGLASPQAGPRVLNAIQTAERVGFPEARIPLANAVIELCLSPKSNSAIL AIDEALADIRAGKIGDVPKHLKDAHYKGAQELGRGIDYKYPHNYDNGWVEQQYLPDPL KNKQYYKPKQTGKFESALKQVYDKLMKRK*" /label="rarA CDS" gene 2318750..2320015 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /label="rarA gene" downshifts 2320014 /Source="Nicolas_upshifts" /id="D1408" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="1.09429" /MaxDrop="4.5261" /score="14.6665846" /energy="-12" /TU="NA" /idTUdmin="U2123" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2320057..2320821) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /EC_number="6.1.-.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12177353, 20097860, 23242255, 27913733, 28671653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA threonylcarbamoyladenosine dehydratase (t(6)A37 dehydratase)" /protein_id="NP_390632.3" /db_xref="EnsemblGenomes-Gn:BSU27540" /db_xref="EnsemblGenomes-Tr:CAB14713" /db_xref="GOA:O32037" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13807" /db_xref="UniProtKB/Swiss-Prot:O32037" /translation="MLHQFSRNELAIGKEGLETLKNSTVAVLGVGGVGSFAAEALARS GVGRILLVDKDDVDITNVNRQLHALLSTVGQPKVDLMKARIADINPECEVIALKMFYT EETYEQFFDYGLDYVIDASDTICYKIHLMKECLKRDIPLISSMGAANKTDPTRFQIAD ISKTHTDPIAKVVRTKLRKEGIKKGVQVIFSDESPIVIREDVRKEVGNDEAKIRKAKM PPSSNAFVPSVAGLIMGGHVVMDLLKDIEIKRVKDK*" /label="tcdA CDS" gene complement(2320057..2320821) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /label="tcdA gene" downshifts complement(2320075) /Source="Nicolas_upshifts" /id="D1409" /incds=0 /nref=246 /ntot=264 /MaxReadThrough="2.35294" /MaxDrop="7.20309" /score="44.7253801" /energy="-12" /TU="NA" /idTUdmin="U2125" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(2320905..2321105) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /product="6Sb RNA" /experiment="publication(s) with functional evidences, PMID:12177353, 15793584, 15811922, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 15793584, 15811922, 25576829, 26873600; Product type n: RNA" /label="ssrSB RNA" gene complement(2320905..2321105) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /label="ssrSB gene" downshifts complement(2320923) /Source="Nicolas_upshifts" /id="D1410" /incds=0 /nref=81 /ntot=303 /MaxReadThrough="7.44881" /MaxDrop="6.73892" /score="44.7253801" /energy="-12" /TU="U2125,U2127" /idTUdmin="U2125" /TUdmin="-848" /isTUend="FALSE" /label="downshifts" upshifts 2321092 /Source="Nicolas_upshifts" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2321093..2321102 /Source="Nicolas_upshift_promotors" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2321103..2321122) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2321114) /Source="Nicolas_upshifts" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2321135..2321142) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2321157..2322935) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /EC_number="6.1.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12177353, 26804570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartyl-tRNA synthetase, promiscuous (also recognizes tRNAasn)" /protein_id="NP_390633.1" /db_xref="EnsemblGenomes-Gn:BSU27550" /db_xref="EnsemblGenomes-Tr:CAB14714" /db_xref="GOA:O32038" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004115" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004524" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029351" /db_xref="SubtiList:BG12572" /db_xref="UniProtKB/Swiss-Prot:O32038" /translation="MFGRTYYCGDITEKAIGESVTLKGWVQKRRDLGGLIFIDLRDRT GIVQVVFNPDVSKEALAIAEGIRNEYVLDIQGKVVAREEGTVNPNLKTGAIEIHADGV NVLNAAKTPPFAISDQAEEVSEDVRLKHRYLDLRRPAMFQTMQLRHNVTKAVRSFLDE NGFLDIETPILTGSTPEGARDYLVPSRVHEGEFYALPQSPQLFKQLLMVSGIERYYQI ARCFRDEDLRADRQPEFTQIDIEMSFMSQEDIMSLAEEMMAKVMRETKGEELQLPLPR MTYDEAMNKYGSDKPDTRFDMLLTDVSDIVKDTEFKVFSSAVANGGVVKAINVKGGAG DYSRKDIDALGAFAANYGAKGLAWVKVEADGVKGPIAKFFDEEKQSKLIEALDAAEGD LLLFGADQFEVVAASLGALRLKLGKERGLIDEKLFNFLWVIDWPLLEHDPEEGRFYAA HHPFTMPVREDLELIETAPEDMKAQAYDLVLNGYELGGGSIRIFEKDIQEKMFALLGF SPEEAAEQFGFLLEAFEYGAPPHGGIALGLDRLVMLLAGRTNLRDTIAFPKTASASCL MTEAPGEVSDAQLDELHLSIKKKVKN*" /label="aspS CDS" gene complement(2321157..2322935) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /label="aspS gene" CDS complement(2322949..2324223) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /EC_number="6.1.1.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28321488; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase" /protein_id="NP_390634.1" /db_xref="EnsemblGenomes-Gn:BSU27560" /db_xref="EnsemblGenomes-Tr:CAB14715" /db_xref="GOA:O32039" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR015807" /db_xref="InterPro:IPR033656" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG12605" /db_xref="UniProtKB/Swiss-Prot:O32039" /translation="MGYNIPRGTQDILPGESDRWQFVEQIMRDTCRTYQYKEIRTPIF EHTELFARGVGESTDIVQKEMYTFEDRKGRSLTLRPEGTAAAVRAFNENKLFANPVQP TKLYYVGPMFRYERPQTGRYRQFYQFGIEAIGSKDPAIDAEVMALAMSIYEKAGLENV KLVINSLGDQDSRKSYREALVKHFEPRIEEFCSDCQSRLHTNPLRILDCKKDRDHELM KSAPSILTYLNEESAAYFEKVKQYLNDLGISYEIDPNLVRGLDYYNHTAFEIMSNAEG FGAITTLAGGGRYDGLVEQIGGPEAPGIGFAMSIERLLAAIDAEKRELPVDKGIDCYI VTLGEKAKDYSVSLVYKLREAGISSEIDYENKKMKGQFKTADRLKARFIAILGEDELA QNKINVKDAQTGEQIEVALDEFIHVMKANQKG*" /label="hisS CDS" gene complement(2322949..2324223) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /label="hisS gene" misc_RNA complement(2324313..2324545) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /product="T-box riboswitch controlling synthesis of histidine and aspartate tRNA ligases" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.3: Control" /label="tboH RNA" gene complement(2324313..2324545) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /label="tboH gene" downshifts complement(2324343) /Source="Nicolas_upshifts" /id="D1411" /incds=0 /nref=71 /ntot=180 /MaxReadThrough="7.0761" /MaxDrop="5.61082" /score="40.6097692" /energy="-23.7" /TU="U2127" /idTUdmin="U2128" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2324555..2324558 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2324569..2324588) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2324573..2324592 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2324575..2324859 /Source="Nicolas_S_feature" /locus_tag="new_2818161_2818445" /HighExp="H2O2, G135, G180, C30, G150, Paraq, Oxctl, dia15, LBGstat, LBGexp" /AntisenseName="yrzK" /AntisenseCor="-0.27832941694878799" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1044" upshifts 2324575 /Source="Nicolas_upshifts" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2324588) /Source="Nicolas_upshifts" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2324603..2324610) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2324605..2324775) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390635.1" /db_xref="EnsemblGenomes-Gn:BSU27570" /db_xref="EnsemblGenomes-Tr:CAB14716" /db_xref="InterPro:IPR035378" /db_xref="SubtiList:BG13820" /db_xref="UniProtKB/Swiss-Prot:O32040" /translation="MKYHPKMGRAFHDGEANLHYSDHADPDTTGYLTETASEFGLMSK EAALRKNNRNKA*" /label="yrzK CDS" gene complement(2324605..2324775) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /label="yrzK gene" promotor_-10 complement(2324806..2324817) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-10" upshifts complement(2324823) /Source="Nicolas_upshifts" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="upshifts" promotor_-35 complement(2324832..2324838) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-35" promotor_-35 2324835..2324842 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2324856..2324874 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2324861 /Source="Nicolas_upshifts" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2324908..2326464 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /EC_number="3.5.1.28" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetylmuramoyl-L-alanine amidase, family 3" /protein_id="NP_390636.1" /db_xref="EnsemblGenomes-Gn:BSU27580" /db_xref="EnsemblGenomes-Tr:CAB14717" /db_xref="GOA:O32041" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR017293" /db_xref="SubtiList:BG13806" /db_xref="UniProtKB/Swiss-Prot:O32041" /translation="MNKKYFVLIVCIIFTSALFPTFSSVTAAQGEAVIATDEMNVRSG PGLSYGITAEVKKGERYPILKEDGDWVQIQLGSGEKGWVVSWLITKEDQASTSSSGSS DTVTSTDPDLRMRSGPGTSYEVIGKFPQGSQASVIDKDSGWIKISYHSATGWVSSEYV TSGGSSSASDESDQTEDSGASTTGTVGVSSLNVRASASHDAAIITKLDRGTKLTVLNE KNGWAHIEVNGLKGWVASHYLLTSSVPADDSANAGSSSSAKKAYIMYGGTNLRSDAST SASIVERAAKGDSYTITGSKGSWYEIKLDNGQTAYVANWVVQTSKSAEEAGEPPVSDS PSGNGSLNNKTIIVDPGHGGKDSGTIGYSGKFEKNLTIKTAKLLASKLRSAGADVYVT RQDDTFVSLQSRVSTSHYRNADAFISIHYDSYADTSTRGSTAYYYSPAKDQELASDVH SEVVKRSSIPDRGVLFGDYYVLRENRQPAMLYELGYVSHPQEEAIVHSNSYQEKVTDG IESGLEKYFQ*" /label="yrvJ CDS" gene 2324908..2326464 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /label="yrvJ gene" downshifts 2326443 /Source="Nicolas_upshifts" /id="D1412" /incds=0 /nref=199 /ntot=249 /MaxReadThrough="2.10072" /MaxDrop="7.40599" /score="44.9570925" /energy="-9.9" /TU="U2126" /idTUdmin="U2129" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2326491..2326889) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15292242, 15525705, 16844682, 18700836, 28362257; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gly-tRNA(Ala) deacylase / D-Tyr-tRNATyr deacylase" /protein_id="NP_390637.2" /db_xref="EnsemblGenomes-Gn:BSU27590" /db_xref="EnsemblGenomes-Tr:CAB14718" /db_xref="GOA:O32042" /db_xref="InterPro:IPR003732" /db_xref="InterPro:IPR023509" /db_xref="SubtiList:BG13805" /db_xref="UniProtKB/Swiss-Prot:O32042" /translation="MDEEVVGQIGQGLMVLVGITHDDTEDDAAYLADKVVNLRIFDDS EGKMNLSLVDIGGEILSVSQFTLYGDTKKGRRPNYMNAAKPDKALGLYEKWNDLLREK GIKVETGTFGAMMDVQLTNSGPVTLIMDSK*" /label="dtd CDS" gene complement(2326491..2326889) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /label="dtd gene" downshifts complement(2326499) /Source="Nicolas_upshifts" /id="D1413" /incds=0 /nref=152 /ntot=267 /MaxReadThrough="2.01735" /MaxDrop="9.47739" /score="37.3693259" /energy="-9.9" /TU="NA" /idTUdmin="U2130" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2326943..2329147) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /EC_number="2.7.6.5" /EC_number="3.1.7.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTP pyrophosphokinase (RelA/SpoT)" /protein_id="NP_390638.2" /db_xref="EnsemblGenomes-Gn:BSU27600" /db_xref="EnsemblGenomes-Tr:CAB14719" /db_xref="GOA:O54408" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004811" /db_xref="InterPro:IPR007685" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR033655" /db_xref="SubtiList:BG12665" /db_xref="UniProtKB/Swiss-Prot:O54408" /translation="MANEQVLTAEQVIDKARSYLSDEHIAFVEKAYLYAEDAHREQYR KSGEPYIIHPIQVAGILVDLEMDPSTIAGGFLHDVVEDTDVTLDDLKEAFSEEVAMLV DGVTKLGKIKYKSQEEQQAENHRKMFVAMAQDIRVILIKLADRLHNMRTLKHLPQEKQ RRISNETLEIFAPLAHRLGISKIKWELEDTALRYLNPQQYYRIVNLMKKKRAERELYV DEVVNEVKKRVEEVNIKADFSGRPKHIYSIYRKMVLQNKQFNEIYDLLAVRILVNSIK DCYAVLGIIHTCWKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKGDPLEVQIRTFEMHE IAEYGVAAHWAYKEGKAANEGATFEKKLSWFREILEFQNESTDAEEFMESLKIDLFSD MVYVFTPKGDVIELPSGSVPIDFSYRIHSEIGNKTIGAKVNGKMVTLDHKLRTGDIVE ILTSKHSYGPSQDWVKLAQTSQAKHKIRQFFKKQRREENVEKGRELVEKEIKNLDFEL KDVLTPENIQKVADKFNFSNEEDMYAAVGYNGITALQVANRLTEKERKQRDQEEQEKI VQEVTGEPKPYPQGRKREAGVRVKGIDNLLVRLSKCCNPVPGDDIVGFITKGRGVSVH REDCPNVKTNEAQERLIPVEWEHESQVQKRKEYNVEIEILGYDRRGLLNEVLQAVNET KTNISSVSGKSDRNKVATIHMAIFIQNINHLHKVVERIKQIRDIYSVRRVMN*" /label="rsh CDS" gene complement(2326943..2329147) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /label="rsh gene" promotor_-10 complement(2329176..2329195) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2329183) /Source="Nicolas_upshifts" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2329185..2329275) /Source="Nicolas_S_feature" /locus_tag="new_2822771_2822861_c" /HighExp="Cold, G135, G180, G150, H2O2, Paraq, Oxctl, C30, LBGexp, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="0.951, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 1" /label="S1045" promotor_-35 complement(2329210..2329217) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2329239 /Source="Nicolas_upshifts" /id="D1414" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="1.75679" /MaxDrop="3.54336" /score="0.486890657" /energy="-12.7" /TU="NA" /idTUdmin="U2126" /TUdmin=2772 /isTUend="FALSE" /label="downshifts" CDS complement(2329315..2329827) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /EC_number="2.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 9383190, 15629952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 9383190, 15629952; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine phosphoribosyltransferase" /protein_id="NP_390639.1" /db_xref="EnsemblGenomes-Gn:BSU27610" /db_xref="EnsemblGenomes-Tr:CAB14720" /db_xref="GOA:O34443" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005764" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG12568" /db_xref="UniProtKB/Swiss-Prot:O34443" /translation="MDLKQYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVEYA KEKQIDLVVGPEARGFIIGCPVAYALGVGFAPVRKEGKLPREVIKVDYGLEYGKDVLT IHKDAIKPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLIELSYLDGRNKLE DYDILTLMKY*" /label="apt CDS" gene complement(2329315..2329827) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /label="apt gene" downshifts complement(2329320) /Source="Nicolas_upshifts" /id="D1415" /incds=0 /nref=39 /ntot=228 /MaxReadThrough="5.36411" /MaxDrop="4.05036" /score="2.83935873" /energy="-6.8" /TU="U2131,U2132,U2133" /idTUdmin="U2131" /TUdmin="-115" /isTUend="FALSE" /label="downshifts" CDS complement(2329833..2332193) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21087930, 21170359, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21087930, 21170359, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="single-strand DNA-specific exonuclease" /protein_id="NP_390640.1" /db_xref="EnsemblGenomes-Gn:BSU27620" /db_xref="EnsemblGenomes-Tr:CAB14721" /db_xref="GOA:O32044" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR004610" /db_xref="InterPro:IPR018779" /db_xref="SubtiList:BG13804" /db_xref="UniProtKB/Swiss-Prot:O32044" /translation="MLASKMRWEIQRPDQDKVKSLTEQLHITPLVASLLVKRGFDTAE SARLFLHTKDADFYDPFEMKGMKEAADRIKQAISQQEKIMIYGDYDADGVTSTSVMLH TLQKLSAQVDFYIPDRFKEGYGPNEQAFRSIKERGFSLIITVDTGIAAVHEAKVAKEL GLDVIITDHHEPGPELPDVRAIVHPKQPGCTYPFKELAGVGVAFKLAHALLGELPDEL LDLAAIGTIADLVPLHDENRLIATLGLERLRRTNRLGLKELIKLSGGDIGEANEETVG FQLAPRLNAVGRIEQADPAVHLLMSEDSFEAEELAAEIDQLNKERQKMVSKMTDEAIE MVEQQGLDQTAIVVAKAGWNPGVVGIVASKLVDRFYRPAIVLGIDEEKGIAKGSARSI RGFNLFESLSECRDILPHFGGHPMAAGMTLKAEDVPDLRSRLNEIADNTLTEEDFIPV QEVDLVCGVEDITVESIAEMNMLSPFGMLNPKPHVLVENAVLEDVRKIGANKTHVKMT IRNESSQLDCVGFNKGELQEGIVPGSRISIVGEMSINEWNNRKKPQLMIKDAAVSEWQ LFDLRGKRTWEDTVSALPSAKRAIVSFKEDSTTLLQTEDLRREVHVISSKDQAKAFDL DGAYIVLLDPPPSLDMLARLLEGKAPERIYFIFLNHEDHFLSTFPARDHFKWYYAFLL KRGAFDVKKHGSELAKHKGWSVETINFMTKVFFDLGFVKIENGVLSVVSGAKKRDLTD SQTYQAKQQLMELDQKLNYSSAEELKEWLNKLMKQDSEAYESTRRT*" /label="recJ CDS" gene complement(2329833..2332193) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /label="recJ gene" promotor_-10 complement(2330297..2330316) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2330305) /Source="Nicolas_upshifts" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="upshifts" promotor_-35 complement(2330330..2330339) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-35" promotor_-10 complement(2332207..2332226) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2332218) /Source="Nicolas_upshifts" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2332241..2332247) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2332260..2332583) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390641.1" /db_xref="EnsemblGenomes-Gn:BSU27630" /db_xref="EnsemblGenomes-Tr:CAB14722" /db_xref="GOA:O32045" /db_xref="InterPro:IPR010445" /db_xref="SubtiList:BG13803" /db_xref="UniProtKB/Swiss-Prot:O32045" /translation="MNKQWTIIFALIFTLIVAIFAVINVRSVEVDYLFGRSEWPLILV ILGSVLMGALIVFSVGIFQVMKLKREIKTLRKENRTAIHKQEDTHLADQTDTQDASAM IEKKD*" /label="yrvD CDS" gene complement(2332260..2332583) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /label="yrvD gene" promotor_-10 complement(2332604..2332622) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2332615) /Source="Nicolas_upshifts" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="upshifts" promotor_-35 complement(2332637..2332643) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-35" CDS complement(2332659..2333156) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative potassium transport accessory component" /protein_id="NP_390642.1" /db_xref="EnsemblGenomes-Gn:BSU27640" /db_xref="EnsemblGenomes-Tr:CAB14723" /db_xref="GOA:O32046" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13802" /db_xref="UniProtKB/Swiss-Prot:O32046" /translation="MRVRESELPGIGQKVEMITRNRDKISIIIHHDGRRELYYFDEND HEECVASVQFDDAEARQMSAILGGMAYKPKALEQVESALDDLIIEWCKAEAGAPAIHQ TIGDLNVGQEYHVTVIAIVKKNQDKQLNPSSETVIDEGDTLVISGEGTGLKRLIREKL TAKGA*" /label="yrvC CDS" gene complement(2332659..2333156) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /label="yrvC gene" S_feature complement(2333157..2333232) /Source="Nicolas_S_feature" /locus_tag="new_2826743_2826818_c" /HighExp="Oxctl, HiOs, G180, LBGexp, Paraq, G150, G135, H2O2, MG-0.2, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1046" promotor_-10 complement(2333226..2333245) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-10" upshifts complement(2333232) /Source="Nicolas_upshifts" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="upshifts" promotor_-35 complement(2333259..2333266) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-35" CDS complement(2333314..2335527) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9694879, 15941986, 15995216, 16517687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9694879, 15941986, 15995216, 16517687; Product type t: transporter" /codon_start=1 /transl_table=11 /product="protein-export membrane protein" /protein_id="NP_390643.1" /db_xref="EnsemblGenomes-Gn:BSU27650" /db_xref="EnsemblGenomes-Tr:CAB14724" /db_xref="GOA:O32047" /db_xref="InterPro:IPR005665" /db_xref="InterPro:IPR005791" /db_xref="InterPro:IPR022645" /db_xref="InterPro:IPR022646" /db_xref="InterPro:IPR022813" /db_xref="SubtiList:BG12672" /db_xref="UniProtKB/Swiss-Prot:O32047" /translation="MKKGRLIAFFLFVLLIGTGLGYFTKPAANNITLGLDLQGGFEVL YDVQPVKKGDKITKDVLVSTVEALNRRANVLGVSEPNIQIEGNNRIRVQLAGVTNQNR AREILATEAQLSFRDANDKELLNGADLVENGAKQTYDSTTNEPIVTIKLKDADKFGEV TKKVMKMAPNNQLVIWLDYDKGDSFKKEVQKEHPKFVSAPNVSQELNTTDVKIEGHFT AQEAKDLASILNAGALPVKLTEKYSTSVGAQFGQQALHDTVFAGIVGIAIIFLFMLFY YRLPGLIAVITLSVYIYITLQIFDWMNAVLTLPGIAALILGVGMAVDANIITYERIKE ELKLGKSVRSAFRSGNRRSFATIFDANITTIIAAVVLFIFGTSSVKGFATMLILSILT SFITAVFLSRFLLALLVESRWLDRKKGWFGVNKKHIMDIQDTDENTEPHTPFQKWDFT SKRKYFFIFSSAVTVAGIIILLVFRLNLGIDFASGARIEVQSDHKLTTEQVEKDFESL GMDPDTVVLSGEKSNIGVARFVGVPDKETIAKVKTYFKDKYGSDPNVSTVSPTVGKEL ARNALYAVAIASIGIIIYVSIRFEYKMAIAAIASLLYDAFFIVTFFSITRLEVDVTFI AAILTIIGYSINDTIVTFDRVREHMKKRKPKTFADLNHIVNLSLQQTFTRSINTVLTV VIVVVTLLIFGASSITNFSIALLVGLLTGVYSSLYIAAQIWLAWKGRELKKDSAQ*" /label="secDF CDS" gene complement(2333314..2335527) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /label="secDF gene" downshifts complement(2333319) /Source="Nicolas_upshifts" /id="D1416" /incds=0 /nref=174 /ntot=249 /MaxReadThrough="4.49738" /MaxDrop="5.0013" /score="29.1843057" /energy="-17.8" /TU="U2137" /idTUdmin="U2137" /TUdmin="-1100" /isTUend="FALSE" /label="downshifts" promotor_-35 2335086..2335091 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2335105..2335124 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2335113 /Source="Nicolas_upshifts" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2335566..2335862) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19028902, 27059541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19028902, 27059541; Product type r: regulator" /codon_start=1 /transl_table=11 /product="post-transcriptional regulator" /protein_id="NP_390644.1" /db_xref="EnsemblGenomes-Gn:BSU27660" /db_xref="EnsemblGenomes-Tr:CAB14726" /db_xref="GOA:O32049" /db_xref="InterPro:IPR025716" /db_xref="SubtiList:BG13814" /db_xref="UniProtKB/Swiss-Prot:O32049" /translation="MEKHPADLYKDHVRPFLYSKLEEFKILGYDDVELESLWSYLTDK KWKKKTELSIYELASDILSVKIGEFMNYATVESFKTSNWLGSEEGQEALEELLR*" /label="comN CDS" gene complement(2335566..2335862) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /label="comN gene" downshifts 2335773 /Source="Nicolas_upshifts" /id="D1417" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.36122" /MaxDrop="2.33158" /score="-9.07145122" /energy="-8.4" /TU="NA" /idTUdmin="U2136" /TUdmin="-2508" /isTUend="FALSE" /label="downshifts" S_feature complement(2335863..2335941) /Source="Nicolas_S_feature" /locus_tag="new_2829449_2829527_c" /HighExp="LBGtran, Lbtran, C90, M40t45, HiOs, Lbexp, Cold, M0t45, UNK1, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigH" /TUlongPSig=1 /label="S1047" promotor_-35 2335903..2335908 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-35" promotor_-10 2335925..2335943 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-10" promotor_-10 complement(2335927..2335946) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-10" upshifts 2335927 /Source="Nicolas_upshifts" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="upshifts" upshifts complement(2335941) /Source="Nicolas_upshifts" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="upshifts" S_feature complement(2335943..2336861) /Source="Nicolas_S_feature" /locus_tag="new_2829529_2830447_c" /HighExp="S2, M9-stat, Lbstat, BC, T2.0H, T3.0H, T2.30H, T3.30H, Cold, M0t90" /AntisenseName="spoVB" /AntisenseCor="-8.5173616652496897E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1048" promotor_-35 complement(2335961..2335964) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-35" CDS 2335978..2337534 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1744050, 15292147, 15849754, 16850406, 17714441, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744050, 15292147, 15849754, 16850406, 17714441, 19648239; Product type t : transporter" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation); translocase with flippase function for peptidoglycan synthesis" /protein_id="NP_390645.1" /db_xref="EnsemblGenomes-Gn:BSU27670" /db_xref="EnsemblGenomes-Tr:CAB14727" /db_xref="GOA:Q00758" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR014249" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10778" /db_xref="UniProtKB/Swiss-Prot:Q00758" /translation="MAKQTFLKGTLILIAAGMVTRMLGFVNRVVIARFIGEEGVGLYM MAAPTFFLATTLTQFGLPVAISKLVAEASARGDHQKTKNILVMSLTITGVLSLIFTPL FLFFAPVMAETMLTDKRTLYPLLAITPVVPIIAISSVLRGYFQGKQNMNPLAMSQVLE QVVRISLVAVCTTIFLPYGIEYAAAGAMLSSVAGELASLLYLFVCFKYKKTIKIRKHF LQSIKNGKQTFTQLMSVSLPTTGSRFIGNLSWFFEPIVVAQSLAIAGVATVAATKQYG ELTGFAMTLLTLPSFITYSLSTALVPAISEGMEQKKLQVVEYRLEQAMRLCLLSGGIS VVILFVFADELMRVMYGSSGAAVFIKVMAPFFLLYYFQGPLQAVLQALNLAGAAMMNS LIGALVKTGLIFVLATRPSLGIMGAALAIVTGMVLVTLLHAATVSKVLPISIKIKEYA LSFAVIVICGFISSAIKQYISFGASEAVNLAGWIAASAAIYMILLLVFRLIKKDELRR IPIIGRLIIR*" /label="spoVB CDS" gene 2335978..2337534 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /label="spoVB gene" promotor_-10 complement(2336847..2336865) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-10" upshifts complement(2336861) /Source="Nicolas_upshifts" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="upshifts" promotor_-35 complement(2336877..2336885) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-35" S_feature 2337535..2338299 /Source="Nicolas_S_feature" /locus_tag="new_2831121_2831885" /HighExp="S3, BT, S4, LoTm, S7, S8, T5.0H, T4.0H, M9-stat, T3.30H" /AntisenseName="yrbG" /AntisenseCor="0.65629957843767395" /AntisenseRegPval="-33.799999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1049" CDS complement(2337538..2338194) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390646.1" /db_xref="EnsemblGenomes-Gn:BSU27680" /db_xref="EnsemblGenomes-Tr:CAB14728" /db_xref="GOA:O32050" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG13786" /db_xref="UniProtKB/Swiss-Prot:O32050" /translation="MEELLTIAFRTVVLYFVILVIFRFMGKREIGELSILDLVVFIMM AEIAVLAIENVDDHLFHTILPMLVLMIIQVTLAYFSLKNRKVRQLLDGKPTIIIKYGK IDEEAMKSQRYNFDDLMVQLRENSIDRVADVSFAILEPSGKLTIVKKENSGEHRQLEM PLIIDGFIQTENLSRISKDRKWLLESLQKHGYTNPSDISFCSFTDGEIYIDEKDGHRT *" /label="yrbG CDS" gene complement(2337538..2338194) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /label="yrbG gene" promotor_-10 complement(2338213..2338224) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2338225) /Source="Nicolas_upshifts" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2338238..2338244) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2338277..2338282 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2338298..2338316 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2338301 /Source="Nicolas_upshifts" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2338329..2338781 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390647.1" /db_xref="EnsemblGenomes-Gn:BSU27690" /db_xref="EnsemblGenomes-Tr:CAB14729" /db_xref="GOA:O32051" /db_xref="InterPro:IPR023804" /db_xref="SubtiList:BG13815" /db_xref="UniProtKB/Swiss-Prot:O32051" /translation="MSDGFEQKEQKPFNTGREETIMEETKQVGKGILYGLIAIFSAML LTSLAVSLLLTATSLEESSFNWLITAISFLSLFIGGFISGGKGKERGWMIGALTALSF SLIILLFQYLGFGKTFTAEQLIFHLGFLGVCMLGGIFGVNMRGNRSST*" /label="yrzE CDS" gene 2338329..2338781 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /label="yrzE gene" downshifts 2338765 /Source="Nicolas_upshifts" /id="D1418" /incds=0 /nref=39 /ntot=61 /MaxReadThrough="1.45569" /MaxDrop="7.7199" /score="41.7975947" /energy="-15" /TU="NA" /idTUdmin="U2140" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2338820) /Source="Nicolas_upshifts" /id="D1419" /incds=0 /nref=188 /ntot=281 /MaxReadThrough="2.20451" /MaxDrop="7.91954" /score="33.5938356" /energy="-15" /TU="NA" /idTUdmin="U2141" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2338838..2339104) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10974125, 16166550, 21235483, 26790414; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the preprotein translocase" /protein_id="NP_390648.2" /db_xref="EnsemblGenomes-Gn:BSU27700" /db_xref="EnsemblGenomes-Tr:CAB14730" /db_xref="GOA:O32052" /db_xref="InterPro:IPR003849" /db_xref="SubtiList:BG13785" /db_xref="UniProtKB/Swiss-Prot:O32052" /translation="MTGTLGTLVPIILMFAVLYFLLIRPQQKQQKAVRQMQEELKKGD SVVTIGGLHGTVDSIDESKVVIKTGDNTRLTFDRRAIREVSAAE*" /label="yrbF CDS" gene complement(2338838..2339104) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /label="yrbF gene" CDS complement(2339141..2340286) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /EC_number="2.4.2.29" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12123838, 14660578, 16199558, 16206323; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-guanine transglycosylase" /protein_id="NP_390649.1" /db_xref="EnsemblGenomes-Gn:BSU27710" /db_xref="EnsemblGenomes-Tr:CAB14731" /db_xref="GOA:O32053" /db_xref="InterPro:IPR002616" /db_xref="InterPro:IPR004803" /db_xref="InterPro:IPR036511" /db_xref="SubtiList:BG12686" /db_xref="UniProtKB/Swiss-Prot:O32053" /translation="MAEQPIRYEFIKECKQTGARLGKVHTPHGSFETPVFMPVGTLAT VKTMSPEELKAMDAGIILSNTYHLWLRPGQDIVKEAGGLHKFMNWDRAILTDSGGFQV FSLSKFRNIEEEGVHFRNHLNGDKLFLSPEKAMEIQNALGSDIMMAFDECPPYPAEYD YMKRSVERTSRWAERCLNAHNRQDEQGLFGIVQGGEYEDLRTQSAKDLISLDFPGYAI GGLSVGEPKDVMNRVLEFTTPLLPKDKPRYLMGVGSPDALIDGAIRGVDMFDCVLPTR IARNGTVFTAEGRLNMKNAKFERDFRPIDEECDCYTCKNYTRAYIRHLIRCNETFGLR LTTYHNLHFLLHLMEQVRQAIREDRLGDFREEFFERYGYNKPNAKSF*" /label="tgt CDS" gene complement(2339141..2340286) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /label="tgt gene" upshifts complement(2339193) /Source="Nicolas_upshifts" /id="U2141" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.432567432567433" /psig="0.164835164835165" /xcortree=2327 /SigmaFactorBS="tacacttaatggagcaggtaagacaggctattcgcgaggatc gtctgggtgatttcaGagaagagttctttgagcgttacggctataacaagccaaatgc g" /listShort="yrbF" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2339237) /Source="Nicolas_upshifts" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2339239..2339258) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2339273..2339278) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2340313..2341341) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /EC_number="2.4.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15822125, 17083917, 10739928" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15822125, 17083917, 10739928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine tRNA ribosyltransferase-isomerase" /protein_id="NP_390650.1" /db_xref="EnsemblGenomes-Gn:BSU27720" /db_xref="EnsemblGenomes-Tr:CAB14732" /db_xref="GOA:O32054" /db_xref="InterPro:IPR003699" /db_xref="InterPro:IPR036100" /db_xref="PDB:1YY3" /db_xref="SubtiList:BG12662" /db_xref="UniProtKB/Swiss-Prot:O32054" /translation="MKVDLFDFELPERLIAQVPLEQRDASRLMVLDKHTGELTDSSFK HIISFFNEGDCLVLNNTRVLPARLFGTKEDTGAKVELLLLKQETGDKWETLAKPAKRV KKGTVVTFGDGRLKAICTEELEHGGRKMEFQYDGIFYEVLESLGEMPLPPYIKEQLDD KERYQTVYSKEIGSAAAPTAGLHFTEEILQQLKDKGVQIEFITLHVGLGTFRPVSADE VEEHNMHAEFYQMSEETAAALNKVRENGGRIISVGTTSTRTLETIAGEHDGQFKASSG WTSIFIYPGYEFKAIDGMITNFHLPKSSLIMLVSALAGRENILRAYNHAVEEEYRFFS FGDAMLII*" /label="queA CDS" gene complement(2340313..2341341) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /label="queA gene" CDS complement(2341371..2341571) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="YP_003097768.1" /db_xref="EnsemblGenomes-Gn:BSU27729" /db_xref="EnsemblGenomes-Tr:CAX52674" /db_xref="GOA:C0H463" /db_xref="InterPro:IPR021320" /db_xref="UniProtKB/Swiss-Prot:C0H463" /translation="MTEFPKIIMILGAVLLIIGAVLHFVGKMPGDIFVKKGNVTFFFP VVTCIIISVVLSILLNLFGRMK*" /label="yrzS CDS" gene complement(2341371..2341571) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /label="yrzS gene" CDS complement(2341564..2342568) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /EC_number="3.1.22.4" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14701911, 15317759, 16267290, 19422832, 21600217, 24770420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase, ATP-dependent component" /protein_id="YP_054590.1" /db_xref="EnsemblGenomes-Gn:BSU27730" /db_xref="EnsemblGenomes-Tr:CAB14733" /db_xref="GOA:O32055" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004605" /db_xref="InterPro:IPR008823" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12669" /db_xref="UniProtKB/Swiss-Prot:O32055" /translation="MDERLVSSEADNHESVIEQSLRPQNLAQYIGQHKVKENLRVFID AAKMRQETLDHVLLYGPPGLGKTTLASIVANEMGVELRTTSGPAIERPGDLAAILTAL EPGDVLFIDEIHRLHRSIEEVLYPAMEDFCLDIVIGKGPSARSVRLDLPPFTLVGATT RVGLLTAPLRDRFGVMSRLEYYTQEELADIVTRTADVFEVEIDKPSALEIARRSRGTP RVANRLLRRVRDFAQVLGDSRITEDISQNALERLQVDRLGLDHIDHKLLMGMIEKFNG GPVGLDTISATIGEESHTIEDVYEPYLLQIGFIQRTPRGRIVTPAVYHHFQMEAPRYD *" /label="ruvB CDS" gene complement(2341564..2342568) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /label="ruvB gene" CDS complement(2342579..2343184) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /EC_number="3.1.22.4" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16267290, 24770420" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16267290, 24770420; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase" /protein_id="NP_390652.1" /db_xref="EnsemblGenomes-Gn:BSU27740" /db_xref="EnsemblGenomes-Tr:CAB14734" /db_xref="GOA:O05392" /db_xref="InterPro:IPR000085" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR011114" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013849" /db_xref="InterPro:IPR036267" /db_xref="SubtiList:BG11973" /db_xref="UniProtKB/Swiss-Prot:O05392" /translation="MIEFVKGTIDYVSPQYIVIENGGIGYQIFTPNPFIYKERSQETI FTYHHIREDAFSLYGFSTREEKALFTKLLNVTGIGPKGALAILGSGDPGAVIQAIENE DEAFLVKFPGVGKKTARQIILDLKGKLADVVPEMIENLFNHEERLEKQTAETALEEAL EALRVLGYAEKEIKKVLPHLKEEIGLTTDQYVKKALQKLLK*" /label="ruvA CDS" gene complement(2342579..2343184) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /label="ruvA gene" promotor_-10 complement(2343203..2343222) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2343219) /Source="Nicolas_upshifts" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2343221..2343322) /Source="Nicolas_S_feature" /locus_tag="new_2836807_2836908_c" /HighExp="Etha, Heat, S8, S7, S4, S3, S6, S5, Salt, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1050" promotor_-35 complement(2343233..2343239) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2343323..2343835) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10931291, 16049010" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10931291, 16049010; Product type f: factor" /codon_start=1 /transl_table=11 /product="bypass of forespore C, intercompartmental signaling factor" /protein_id="NP_390653.1" /db_xref="EnsemblGenomes-Gn:BSU27750" /db_xref="EnsemblGenomes-Tr:CAB14735" /db_xref="GOA:O05391" /db_xref="InterPro:IPR015050" /db_xref="InterPro:IPR015071" /db_xref="PDB:2BW2" /db_xref="SubtiList:BG11917" /db_xref="UniProtKB/Swiss-Prot:O05391" /translation="MKRFSTAYLLLGILCSAAVFLIGAPSRALGAEVEHYEPLQVHVQ LEKVYLDGDVSIEHKHEKVFSMDDFWAAYAGWTLVEQKKGYVLFRKQMDDISPLSKVN GYIGVSDNGVISTFHGRPEPASEPIQSFFQIDLERLESHMQKNLLKGIPFRTKAEFED VIEHMKTYSG*" /label="bofC CDS" gene complement(2343323..2343835) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /label="bofC gene" promotor_-10 complement(2343864..2343875) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-10" upshifts complement(2343879) /Source="Nicolas_upshifts" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="upshifts" CDS complement(2343883..2345190) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9099855, 14638426, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative catecholate siderophose exporter" /protein_id="NP_390654.2" /db_xref="EnsemblGenomes-Gn:BSU27760" /db_xref="EnsemblGenomes-Tr:CAB14736" /db_xref="GOA:O05390" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11922" /db_xref="UniProtKB/Swiss-Prot:O05390" /translation="MNTVHAKGNVLNKIGIPSHMVWGYIGVVIFMVGDGLEQGWLSPF LVDHGLSMQQSASLFTMYGIAVTISAWLSGTFVQTWGPRKTMTVGLLAFILGSAAFIG WAIPHMYYPALLGSYALRGLGYPLFAYSFLVWVSYSTSQNILGKAVGWFWFMFTCGLN VLGPFYSSYAVPAFGEINTLWSALLFVAAGGILALFFNKDKFTPIQKQDQPKWKELSK AFTIMFENPKVGIGGVVKTINAIGQFGFAIFLPTYLARYGYSVSEWLQIWGTLFFVNI VFNIIFGAVGDKLGWRNTVMWFGGVGCGIFTLALYYTPQLIGHQYWVLMIIACCYGAA LAGYVPLSALLPTLAPDNKGAAMSVLNLGSGLCAFIAPGIVSLFIGPLGAGGVIWIFA ALYFFSAFLTRFLTISEQSTDVYTEERFVRENVQTNFDKTVKQ*" /label="csbX CDS" gene complement(2343883..2345190) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /label="csbX gene" promotor_-35 complement(2343890..2343896) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-35" downshifts complement(2345144) /Source="Nicolas_upshifts" /id="D1420" /incds=0 /nref=2 /ntot=80 /MaxReadThrough="7.18585" /MaxDrop="3.0235" /score="-6.29978124" /energy="-14.3" /TU="U2145,U2146" /idTUdmin="U2146" /TUdmin="-1793" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2345214..2345232) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-10" upshifts complement(2345229) /Source="Nicolas_upshifts" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="upshifts" promotor_-35 complement(2345247..2345253) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-35" CDS complement(2345261..2346286) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative inositol-related oxidoreductase" /protein_id="NP_390655.1" /db_xref="EnsemblGenomes-Gn:BSU27770" /db_xref="EnsemblGenomes-Tr:CAB14737" /db_xref="GOA:O05389" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR030827" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12280" /db_xref="UniProtKB/Swiss-Prot:O05389" /translation="MTKQIVTGIIGAGRIGKLHVQNISRIPHMKIKAISDIQASRIKS WADSHQIEYITSDYRDLLHDPDIDAIFICSPTAVHAQMIKEAAEAKKHIFCEKPVSFS LDETSEALAAVRKHGVTLQVGFNRRFDPHFKKIKTIVENGEIGTPHLLKITSRDPEPP NIDYVRTSGGLFMDMSIHDFDMARYIMGSEVTEVYAKGAALVNPSFAELGDIDTAVIT LTFENGAMAVIDNSRQAVYGYDQRVEVFGTKGSAAADNSRPTTVEVSTADFVMKDKPH FFFLERYKDSYEEEILRFAEAIGTNQETPCTGNDGLQAGRIARAAQQSLAFGMPVSIE HTEKIAF*" /label="yrbE CDS" gene complement(2345261..2346286) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /label="yrbE gene" promotor_-10 complement(2346323..2346342) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-10" upshifts complement(2346343) /Source="Nicolas_upshifts" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="upshifts" promotor_-35 complement(2346357..2346364) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-35" promotor_-35 2346412..2346419 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2346433..2346452 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2346441 /Source="Nicolas_upshifts" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2346473..2346478 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2346487 /Source="Nicolas_upshifts" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2346494..2346512 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2346524..2347171 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /EC_number="2.7.11.1" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative serine/threonine-protein kinase" /protein_id="NP_390656.2" /db_xref="EnsemblGenomes-Gn:BSU27785" /db_xref="EnsemblGenomes-Tr:CAB14738" /db_xref="GOA:O32057" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13816" /db_xref="UniProtKB/Swiss-Prot:O32057" /translation="MLTKAEALAHTVIYRKNSRFDKVKEKSEELTLIGKGRSAYVFAL TEGGRKMALKVFFPEYQATAVKEAAIYEKLAGSAFYPDIYETGDSFILMEYIKGETFY NCLKKGIAISDDMIQQVEEALSDARAAGLNPSDIHLRNLILTETGAVRVIDVARFEQT KTCTQWDDLKSAYHALYKKPIFPKKIPGFWLEIIAFLYKKDWFQKHFAQRKRKYS*" /label="yrzF CDS" gene 2346524..2347171 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /label="yrzF gene" S_feature complement(2346846..2347179) /Source="Nicolas_S_feature" /locus_tag="new_2840432_2840765_c" /HighExp="LPhT, S8, BI, S7, S6, C30, Sw, BC, Gly, C90" /AntisenseName="yrzF" /AntisenseCor="0.348831504804749" /AntisenseRegPval="-8.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1051" downshifts 2347150 /Source="Nicolas_upshifts" /id="D1421" /incds=0 /nref=29 /ntot=228 /MaxReadThrough="2.4121" /MaxDrop="5.05737" /score="20.8102477" /energy="-18.2" /TU="NA" /idTUdmin="U2147" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(2347181..2347378) /Source="Nicolas_S_feature" /locus_tag="new_2840767_2840964_c" /HighExp="LPhT, BI, B60, S8, Gly, S7, S6, B36, S5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984200000000001" /TUshortSig="Sig-" /TUshortPSig="0.032" /TUlongSig="NA" /TUlongPSig="NA" /label="S1052" CDS complement(2347217..2347339) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513992.1" /db_xref="EnsemblGenomes-Gn:BSU27786" /db_xref="EnsemblGenomes-Tr:CCQ48603" /db_xref="UniProtKB/TrEMBL:L8EAY3" /translation="MEKTYCHSGEKDPEAVYLTVRGYRIKLSPEQMKLISAVRK*" /label="hypothetical protein CDS" gene complement(2347217..2347339) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /label="gene" downshifts complement(2347224) /Source="Nicolas_upshifts" /id="D1422" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="4.39913" /MaxDrop="4.52186" /score="39.5790138" /energy="-18.2" /TU="NA" /idTUdmin="U2149" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(2347387) /Source="Nicolas_upshifts" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2347388..2347405) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2347412..2347419) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2347424..2347714 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390658.2" /db_xref="EnsemblGenomes-Gn:BSU27800" /db_xref="EnsemblGenomes-Tr:CAB14740" /db_xref="SubtiList:BG13818" /db_xref="UniProtKB/Swiss-Prot:O32059" /translation="MNPIYSKMREKKGESHIKTENTLSLDAARGELVNEKTLVKRTIY WNYPDSRPAVTWINHNTVKIGNQTLHLDTDETYDWRKDDHWIREEPPQASVR*" /label="yrzH CDS" gene 2347424..2347714 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /label="yrzH gene" misc_feature 2347435..2347454 /Source="Nicolas_upshift_promotors" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 2347435..2347582 /Source="Nicolas_S_feature" /locus_tag="new_2841021_2841168" /HighExp="T3.30H, T4.0H, T3.0H, T2.0H, T2.30H, T5.0H, M9-stat, S7, T1.30H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigA" /TUshortPSig="0.903" /TUlongSig="NA" /TUlongPSig="NA" /label="S1053" upshifts 2347435 /Source="Nicolas_upshifts" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="upshifts" CDS 2347721..2347861 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097769.1" /db_xref="EnsemblGenomes-Gn:BSU27809" /db_xref="EnsemblGenomes-Tr:CAX52675" /db_xref="GOA:C0H464" /db_xref="UniProtKB/Swiss-Prot:C0H464" /translation="MNKMNGTNDEKHFNHFVIALSFIYGLTELGYLLLKDFITIAISL PL*" /label="yrzT CDS" gene 2347721..2347861 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /label="yrzT gene" downshifts 2347850 /Source="Nicolas_upshifts" /id="D1423" /incds=0 /nref=139 /ntot=241 /MaxReadThrough="0.64189" /MaxDrop="4.74983" /score="23.2933855" /energy="-9.9" /TU="NA" /idTUdmin="U2150" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2347910..2347916 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2347924..2348024 /Source="Nicolas_upshift_promotors" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2347931..2347949 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2347932 /Source="Nicolas_upshifts" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="upshifts" upshifts 2347984 /Source="Nicolas_upshifts" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="upshifts" CDS 2348025..2349479 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1400476, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium/proton-dependent alanine transporter" /protein_id="NP_390659.2" /db_xref="EnsemblGenomes-Gn:BSU27810" /db_xref="EnsemblGenomes-Tr:CAB14741" /db_xref="GOA:O32060" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG13784" /db_xref="UniProtKB/Swiss-Prot:O32060" /translation="MADFVASLNAVLWSTPVIYILLGIGFAFSIMTRFLQVRHLKEMI VQMFKGKSSEAGVSSFQALSIALSGRVGTGNIAGVATAIAFGGPGAVFWMWAIAFIGA ASAFVESTLAQIYKVKQDGQYRGGPAYYIEKGLGIKWFAVLFAAAALIAMAFLMPGVQ SNSIAAGIQNAFGISPFVTGCGLVLLLGFIIFGGVKRIANAAQMIVPFMAIGYILLSL IIIVMNVSELPAVISLIFKSAFALDSAFGGLIGMAISWGVKRGIYSNEAGQGTGPHPA AAAEVSHPVKQGLVQAFSVYIDTLFVCSATAFMILFTGMYNTQAADGSFIVHQLKGVE AGPGFTQAAIDSVLPGFGAGFVAIALFFFAFTTIMAYYYIAETNIAYLARGRESKWAM LGLKLIILAATFYGTVKTASLAWALGDAGLGIMVWLNVIAIVLLAKPALLALKDYERQ KKQGLDPIFDPKALGIKNADFWEKEYTHESERVS*" /label="alaP CDS" gene 2348025..2349479 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /label="alaP gene" downshifts 2349480 /Source="Nicolas_upshifts" /id="D1424" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="5.01314" /MaxDrop="4.4617" /score="6.86850608" /energy="-10.8" /TU="U2151" /idTUdmin="U2152" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2349520..2350242) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12060744, 18641136, 20647113; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor regulating gene expression" /protein_id="NP_390660.1" /db_xref="EnsemblGenomes-Gn:BSU27820" /db_xref="EnsemblGenomes-Tr:CAB14742" /db_xref="GOA:P94447" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG13783" /db_xref="UniProtKB/Swiss-Prot:P94447" /translation="MAGHSKWKNIQKRKNAQDAKRGKIFMKLAKEIYVAAKEGGADPE ANSALRLVIEKAKGANMPNENIDRAIKKAAGGQDGSSYEEITYEGYGPSGIAVMVECV TDNKNRTASNVRTAFNKNGGSLGESGCVAFLFERKGFITIDRTERQIEEDELMLDVLE AGGEELRIEEDLYEVFTEPEHFEEVKTALESKYLISSAEVTMLPNTYAEADDQAVEKL ETLIDVLEDDDDVQEVYTNYRS*" /label="yrbC CDS" gene complement(2349520..2350242) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /label="yrbC gene" S_feature 2349525..2349946 /Source="Nicolas_S_feature" /locus_tag="new_2843111_2843532" /HighExp="S8, S6, S7, BT, C30, S5, S4, LoTm, C90, S3" /AntisenseName="yrbC" /AntisenseCor="-8.4330852334841305E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1054" downshifts complement(2349536) /Source="Nicolas_upshifts" /id="D1425" /incds=0 /nref=11 /ntot=164 /MaxReadThrough="3.2014" /MaxDrop="3.66865" /score="23.9031001" /energy="-16" /TU="U2153" /idTUdmin="U2153" /TUdmin="-574" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2350265..2350284) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2350282) /Source="Nicolas_upshifts" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2350298..2350305) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2350345..2350941) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9770294, 10438771, 12562816, 17322312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9770294, 10438771, 12562816, 17322312; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_390661.2" /db_xref="EnsemblGenomes-Gn:BSU27830" /db_xref="EnsemblGenomes-Tr:CAB14743" /db_xref="GOA:P94446" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13782" /db_xref="UniProtKB/Swiss-Prot:P94446" /translation="MGKKMTIASLILMTAGLTACGANDNAMNDTRNNGNTRPIGYYTN ENDADRQGDGIDHDGPVSELMEDQNDGNRNTTNVNNRDRVTADDRVPLATDGTYNNTN NRNMNRNAANNGYDNQENRRLAAKIANRVKQVKNVNDTQVMVSDDRVVIAVKSHREFT KSDRDNVVKAARNYANGRDVQVSTDKGLFRKLHKMNNR*" /label="sgpA CDS" gene complement(2350345..2350941) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /label="sgpA gene" downshifts complement(2350360) /Source="Nicolas_upshifts" /id="D1426" /incds=0 /nref=96 /ntot=172 /MaxReadThrough="2.47709" /MaxDrop="7.18444" /score="23.9031001" /energy="-16" /TU="NA" /idTUdmin="U2154" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2350984..2350995) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2350986) /Source="Nicolas_upshifts" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2350988..2351052) /Source="Nicolas_S_feature" /locus_tag="new_2844574_2844638_c" /HighExp="B36, LoTm, S8, S6, S5, BT, B60, S4, S7, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1055" promotor_-35 complement(2351010..2351016) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2351089..2352252) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10438771, 10714986, 10714992, 11040425, 15901704, 26953338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438771, 10714986, 10714992, 11040425, 15901704, 26953338; Product type f : factor" /codon_start=1 /transl_table=11 /product="morphogenetic protein associated with SpoVID" /protein_id="NP_390662.1" /db_xref="EnsemblGenomes-Gn:BSU27840" /db_xref="EnsemblGenomes-Tr:CAB14744" /db_xref="GOA:O32062" /db_xref="InterPro:IPR014248" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13781" /db_xref="UniProtKB/Swiss-Prot:O32062" /translation="MKIHIVQKGDSLWKIAEKYGVDVEEVKKLNTQLSNPDLIMPGMK IKVPSEGVPVRKEPKAGKSPAAGSVKQEHPYAKEKPKSVVDVEDTKPKEKKSMPYVPP MPNLQENVYPEADVNDYYDMKQLFQPWSPPKPEEPKKHHDGNMDHMYHMQDQFPQQEA MSNMENANYPNMPNMPKAPEVGGIEEENVHHTVPNMPMPAVQPYYHYPAHFVPCPVPV SPILPGSGLCYPYYPAQAYPMHPMHGYQPGFVSPQYDPGYENQHHENSHHGHYGSYGA PQYASPAYGSPYGHMPYGPYYGTPQVMGAYQPAAAHGYMPYKDHDDCGCDGDHQPYFS APGHSGMGAYGSPNMPYGTANPNPNPYSAGVSMPMTNQPSVNQMFGRPEEENE*" /label="safA CDS" gene complement(2351089..2352252) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /label="safA gene" downshifts complement(2351097) /Source="Nicolas_upshifts" /id="D1427" /incds=0 /nref=34 /ntot=189 /MaxReadThrough="5.61903" /MaxDrop="3.9565" /score="38.1347732" /energy="-11.1" /TU="U2155,U2156,U2159" /idTUdmin="U2154" /TUdmin="-749" /isTUend="FALSE" /label="downshifts" S_feature complement(2352253..2352328) /Source="Nicolas_S_feature" /locus_tag="new_2845839_2845914_c" /HighExp="S5, S4, B36, LoTm, S3, B60, S7, S6, Pyr, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1056" promotor_-10 complement(2352304..2352322) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2352328) /Source="Nicolas_upshifts" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2352338..2352343) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2352369..2353475) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /EC_number="2.5.1.72" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15898769, 15937336, 15967443, 18959769, 26455817" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15898769, 15937336, 15967443, 18959769, 26455817; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quinolinate synthetase" /protein_id="NP_390663.1" /db_xref="EnsemblGenomes-Gn:BSU27850" /db_xref="EnsemblGenomes-Tr:CAB14745" /db_xref="GOA:Q9KWZ1" /db_xref="InterPro:IPR003473" /db_xref="InterPro:IPR023515" /db_xref="InterPro:IPR036094" /db_xref="SubtiList:BG12629" /db_xref="UniProtKB/Swiss-Prot:Q9KWZ1" /translation="MSILDVIKQSNDMMPESYKELSRKDMETRVAAIKKKFGSRLFIP GHHYQKDEVIQFADQTGDSLQLAQVAEKNKEADYIVFCGVHFMAETADMLTSEQQTVV LPDMRAGCSMADMADMQQTNRAWKKLQHIFGDTIIPLTYVNSTAEIKAFVGKHGGATV TSSNAKKVLEWAFTQKKRILFLPDQHLGRNTAYDLGIALEDMAVWDPMKDELVAESGH TNVKVILWKGHCSVHEKFTTKNIHDMRERDPDIQIIVHPECSHEVVTLSDDNGSTKYI IDTINQAPAGSKWAIGTEMNLVQRIIHEHPDKQIESLNPDMCPCLTMNRIDLPHLLWS LEQIEKGEPSGVIKVPKAIQEDALLALNRMLSIT*" /label="nadA CDS" gene complement(2352369..2353475) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /label="nadA gene" promotor_-10 complement(2353051..2353069) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2353076) /Source="Nicolas_upshifts" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2353085..2353090) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2353387 /Source="Nicolas_upshifts" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2353388..2353391 /Source="Nicolas_upshift_promotors" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2353462..2354331) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /EC_number="2.4.2.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8419294, 28618168; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide pyrophosphorylase (quinolinate phosphoribosyltransferase)" /protein_id="NP_390664.1" /db_xref="EnsemblGenomes-Gn:BSU27860" /db_xref="EnsemblGenomes-Tr:CAB14746" /db_xref="GOA:P39666" /db_xref="InterPro:IPR002638" /db_xref="InterPro:IPR004393" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022412" /db_xref="InterPro:IPR027277" /db_xref="InterPro:IPR036068" /db_xref="InterPro:IPR037128" /db_xref="SubtiList:BG10868" /db_xref="UniProtKB/Swiss-Prot:P39666" /translation="MNHLQLKKLLNHFFLEDIGTGDLTSQSIFGEQSCEAEIVAKSEG IFAGAAIIKEGFSLLDENVQSILHKKDGDMLHKGEVIAELHGPAAALLSGERVVLNLI QRLSGIATMTREAVRCLDDEQIKICDTRKTTPGLRMLEKYAVRAGGGYNHRFGLYDGI MIKDNHIAACGSILEACKKARQAAGHMVNIEVEIETEEQLREAIAAGADVIMFDNCPP DTVRHFAKLTPANIKTEASGGITLESLPAFKGTGVNYISLGFLTHSVKSLDISMDVTL SNESVEECCYVNS*" /label="nadC CDS" gene complement(2353462..2354331) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /label="nadC gene" downshifts 2353556 /Source="Nicolas_upshifts" /id="D1428" /incds=1 /nref=4 /ntot=107 /MaxReadThrough="0.495279999999999" /MaxDrop="3.83418" /score="-8.75482157" /energy="-7.4" /TU="NA" /idTUdmin="U2157" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(2354285..2355880) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /EC_number="1.4.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 16199587, 18959769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 16199587, 18959769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-aspartate oxidase" /protein_id="NP_390665.1" /db_xref="EnsemblGenomes-Gn:BSU27870" /db_xref="EnsemblGenomes-Tr:CAB14747" /db_xref="GOA:P38032" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR005288" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10867" /db_xref="UniProtKB/Swiss-Prot:P38032" /translation="MSKKTIAVIGSGAAALSLAAAFPPSYEVTVITKKSVKNSNSVYA QGGIAAAYAKDDSIEAHLEDTLYAGCGHNNLAIVADVLHDGKMMVQSLLERGFPFDRN ERGGVCLGREGAHSYNRIFHAGGDATGRLLIDYLLKRINSKIKLIENETAADLLIEDG RCIGVMTKDSKGRLKVRHADEVVLAAGGCGNLFLHHTNDLTVTGDGLSLAYRAGAELT DLEFTQFHPTLLVKNGVSYGLVSEAVRGEGGCLVDENGRRIMAERHPLGDLAPRDIVS RVIHEEMAKGNRVYIDFSAISDFETRFPTITAICEKAGIDIHSGKIPVAPGMHFLMGG VSVNRWGETTVPGLYAIGETACSGLHGANRLASNSLLEALVFGKRAAEHIIQKPVYNR QYQSGLETSVFYEVPDIEGHELQSKMTSHMSILREQSSLIELSIWLHTLPFQEVNVKD ITIRQMELSHLWQTAKLMTFSALLREESRGAHFRTDFPHAEVSWQGRQIVHTKKGTKI RKNEGIWNNESFTAEKITESLFS*" /label="nadB CDS" gene complement(2354285..2355880) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /label="nadB gene" promotor_-35 2355908..2355915 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2355908..2355927) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2355929 /Source="Nicolas_upshifts" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2355931..2355950 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2355932) /Source="Nicolas_upshifts" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2355942..2355949) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2355983..2357170 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 14567704, 16199587, 25447671, 26443755, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 14567704, 16199587, 25447671, 26443755, 28882201; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="desulfurase involved in iron-sulfur clusters forNAD biosynthesis" /protein_id="NP_390666.1" /db_xref="EnsemblGenomes-Gn:BSU27880" /db_xref="EnsemblGenomes-Tr:CAB14748" /db_xref="GOA:P38033" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG10866" /db_xref="UniProtKB/Swiss-Prot:P38033" /translation="MIYLDYAATTPICEEALTVYQKLSMDMYGNASSLHDAGGKAKHI LEYCREKIANIIGGEASGIYFTSGGTESNFLAIQSLLNGLPKTKRHFITTAMEHQSIH NCAAFLEQQGYDVTVIEPNEYGLITEEILLTHIRPETGLVSIQHANSETGIIQPIQHL SSYLHNKGILLHCDAVQTFGKIPINTKNLGVDALSMSSHKIHGPKGVGAVYIRPDVPW KPVYPLTTHEYGFRAGTVNVPGIGAFTAAAELIVSEMEKQISRNEALRTYFLDQIRIR SLPVTLAADTSKAECLPHIIGCFFHSFEGQYVMLECNRSNICISTGSACSAGYHGPSE TMKALRKTEQEALQFIRISFGRHTTAEQLEQLLHTFTVLWEQKKGEFDIDRRIKANGR QQA*" /label="nifS CDS" gene 2355983..2357170 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /label="nifS gene" promotor_-10 complement(2355984..2356003) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2356002) /Source="Nicolas_upshifts" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2356018..2356027) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2356885..2356890 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2356899 /Source="Nicolas_upshifts" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2356901..2356920 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2357130..2357672 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16199587, 18276644" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16199587, 18276644; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of de novo NAD biosynthesis" /protein_id="NP_390667.2" /db_xref="EnsemblGenomes-Gn:BSU27890" /db_xref="EnsemblGenomes-Tr:CAB14749" /db_xref="GOA:P39667" /db_xref="InterPro:IPR004173" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026043" /db_xref="InterPro:IPR035922" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10865" /db_xref="UniProtKB/Swiss-Prot:P39667" /translation="MTEELKLMGANRRDQLLLWLKESKSPLTGGELAKKANVSRQVIV QDISLLKAKNVPIIATSQGYVYMDAAAQQHQQAERIIACLHGPERTEEELQLIVDEGV TVKDVKIEHPVYGDLTAAIQVGTRKEVSHFIKKINSTNAAYLSQLTDGVHLHTLTAPD EHRIDQACQALEEAGILIKD*" /label="niaR CDS" gene 2357130..2357672 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /label="niaR gene" downshifts 2357655 /Source="Nicolas_upshifts" /id="D1429" /incds=0 /nref=109 /ntot=246 /MaxReadThrough="3.55509" /MaxDrop="5.04771" /score="15.054047" /energy="-5.6" /TU="U2158" /idTUdmin="U2161" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2357697..2358554) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /EC_number="4.2.1.51" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:104661, 114523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104661, 114523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydratase" /protein_id="NP_390668.1" /db_xref="EnsemblGenomes-Gn:BSU27900" /db_xref="EnsemblGenomes-Tr:CAB14750" /db_xref="GOA:P21203" /db_xref="InterPro:IPR001086" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008242" /db_xref="InterPro:IPR018528" /db_xref="SubtiList:BG10914" /db_xref="UniProtKB/Swiss-Prot:P21203" /translation="MKVGYLGPAATFTHLAVSSCFQNGAEHVAYRTIPECIDAAVAGE VDFAFVPLENALEGSVNLTIDYLIHEQPLPIVGEMTLPIHQHLLVHPSRENAWKELDK IYSHSHAIAQCHKFLHRHFPSVPYEYANSTGAAAKFVSDHPELNIGVIANDMAASTYE LKIVKRDIQDYRDNHTRFVILSPDENISFEVNSKLSSRPKTTLMVMLPQDDQSGALHR VLSAFSWRNLNLSKIESRPTKTGLGHYFFIIDIEKAFDDVLIPGAMQELEALGCKVRL LGAYQSYQL*" /label="pheA CDS" gene complement(2357697..2358554) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /label="pheA gene" S_feature 2357700..2358409 /Source="Nicolas_S_feature" /locus_tag="new_2851286_2851995" /HighExp="S2, T-5.40H, T3.30H, T-4.40H, GM-0.2, GM-0.1, Pyr, T4.0H, T5.0H, GM 10" /AntisenseName="pheA" /AntisenseCor="-0.15664933741609299" /AntisenseRegPval="-2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1057" downshifts complement(2357717) /Source="Nicolas_upshifts" /id="D1430" /incds=0 /nref=173 /ntot=247 /MaxReadThrough="1.87872" /MaxDrop="5.15605" /score="13.965695" /energy="-5.6" /TU="NA" /idTUdmin="U2162" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2358571..2359014) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /experiment="publication(s) with functional evidences, PMID:2537815, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2537815, 27260660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of operons hom-thrCB and thrD" /protein_id="NP_390669.1" /db_xref="EnsemblGenomes-Gn:BSU27910" /db_xref="EnsemblGenomes-Tr:CAB14751" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008310" /db_xref="SubtiList:BG10913" /db_xref="UniProtKB/Swiss-Prot:P21204" /translation="MKEETFYLVREDVLPDAMRKTLEVKKLLDRKKADSVADAVQKVD LSRSAFYKYRDAVFPFYTMVKEQIITLFFHLEDRSGALSQLLQAVADSGSNVLSIHQT IPLQGRANVTLSISTSAMEEDIHTLMNKLRKFDFVEKVEILGSGA*" /label="thrR CDS" gene complement(2358571..2359014) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /label="thrR gene" CDS complement(2359075..2360361) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ppGpp-binding GTPase involved in cell portioning, DNA repair and ribosome assembly" /protein_id="NP_390670.1" /db_xref="EnsemblGenomes-Gn:BSU27920" /db_xref="EnsemblGenomes-Tr:CAB14752" /db_xref="GOA:P20964" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR006074" /db_xref="InterPro:IPR006169" /db_xref="InterPro:IPR014100" /db_xref="InterPro:IPR015349" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="InterPro:IPR035101" /db_xref="InterPro:IPR036346" /db_xref="InterPro:IPR036726" /db_xref="PDB:1LNZ" /db_xref="SubtiList:BG10337" /db_xref="UniProtKB/Swiss-Prot:P20964" /translation="MFVDQVKVYVKGGDGGNGMVAFRREKYVPKGGPAGGDGGKGGDV VFEVDEGLRTLMDFRYKKHFKAIRGEHGMSKNQHGRNADDMVIKVPPGTVVTDDDTKQ VIADLTEHGQRAVIARGGRGGRGNSRFATPANPAPQLSENGEPGKERYIVLELKVLAD VGLVGFPSVGKSTLLSVVSSAKPKIADYHFTTLVPNLGMVETDDGRSFVMADLPGLIE GAHQGVGLGHQFLRHIERTRVIVHVIDMSGLEGRDPYDDYLTINQELSEYNLRLTERP QIIVANKMDMPEAAENLEAFKEKLTDDYPVFPISAVTREGLRELLFEVANQLENTPEF PLYDEEELTQNRVMYTMENEEVPFNITRDPDGVFVLSGDSLERLFKMTDFSRDESVKR FARQMRGMGVDEALRERGAKDGDIIRLLEFEFEFID*" /label="obgE CDS" gene complement(2359075..2360361) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /label="obgE gene" CDS complement(2360395..2360973) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation initiation phosphotransferase" /protein_id="NP_390671.1" /db_xref="EnsemblGenomes-Gn:BSU27930" /db_xref="EnsemblGenomes-Tr:CAB14753" /db_xref="GOA:P06535" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR016122" /db_xref="InterPro:IPR037100" /db_xref="PDB:1F51" /db_xref="PDB:1IXM" /db_xref="PDB:2FTK" /db_xref="SubtiList:BG10336" /db_xref="UniProtKB/Swiss-Prot:P06535" /translation="MKDVSKNQEENISDTALTNELIHLLGHSRHDWMNKLQLIKGNLS LQKYDRVFEMIEEMVIDAKHESKLSNLKTPHLAFDFLTFNWKTHYMTLEYEVLGEIKD LSAYDQKLAKLMRKLFHLFDQAVSRESENHLTVSLQTDHPDRQLILYLDFHGAFADPS AFDDIRQNGYEDVDIMRFEITSHECLIEIGLD*" /label="spo0B CDS" gene complement(2360395..2360973) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /label="spo0B gene" S_feature complement(2360974..2361039) /Source="Nicolas_S_feature" /locus_tag="new_2854560_2854625_c" /HighExp="Cold, H2O2, G135, Paraq, G180, Oxctl, G150, C30, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigEF" /TUlongPSig=1 /label="S1058" promotor_-10 complement(2361024..2361043) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2361039) /Source="Nicolas_upshifts" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2361041..2361258) /Source="Nicolas_S_feature" /locus_tag="new_2854627_2854844_c" /HighExp="Cold, G135, H2O2, Paraq, G180, Oxctl, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1059" CDS 2361051..2361173 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513993.1" /translation="MLEKQLFFPEISCSFFLALVDLQPGRTFYVLLLGEHIQWV*" /label="hypothetical protein CDS" gene 2361051..2361173 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /label="gene" promotor_-35 complement(2361057..2361064) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2361294..2361578) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 (BL24)" /protein_id="NP_390672.1" /db_xref="EnsemblGenomes-Gn:BSU27940" /db_xref="EnsemblGenomes-Tr:CAB14754" /db_xref="GOA:P05657" /db_xref="InterPro:IPR001684" /db_xref="InterPro:IPR018261" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10335" /db_xref="UniProtKB/Swiss-Prot:P05657" /translation="MLRLDLQFFASKKGVGSTKNGRDSEAKRLGAKRADGQFVTGGSI LYRQRGTKIYPGENVGRGGDDTLFAKIDGTVKFERFGRDRKKVSVYPVAQ*" /label="rpmA CDS" gene complement(2361294..2361578) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /label="rpmA gene" downshifts complement(2361303) /Source="Nicolas_upshifts" /id="D1431" /incds=0 /nref=212 /ntot=261 /MaxReadThrough="7.39131" /MaxDrop="7.26483" /score="32.4992871" /energy="-12.5" /TU="U2163" /idTUdmin="U2164" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" CDS complement(2361591..2361929) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11567142, 22333191, 25388641, 27435445, 28187498; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 specific N-terminal end cysteine protease" /protein_id="NP_390673.2" /db_xref="EnsemblGenomes-Gn:BSU27950" /db_xref="EnsemblGenomes-Tr:CAB14755" /db_xref="InterPro:IPR007422" /db_xref="InterPro:IPR036764" /db_xref="SubtiList:BG10334" /db_xref="UniProtKB/Swiss-Prot:P26942" /translation="MIQATIRRSHDKGILSFEMTGHANFAEHGQDLVCAGVTAVVFGA VNAVIVLAGFEPLLDIGEDGGYFYFEFPESLDPEARQKAQLLIEGMIVSLETIERDYK DNLRVTTNII*" /label="rppA CDS" gene complement(2361591..2361929) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /label="rppA gene" CDS complement(2361932..2362240) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8223574, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8223574, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L21 (BL20)" /protein_id="NP_390674.1" /db_xref="EnsemblGenomes-Gn:BSU27960" /db_xref="EnsemblGenomes-Tr:CAB14756" /db_xref="GOA:P26908" /db_xref="InterPro:IPR001787" /db_xref="InterPro:IPR018258" /db_xref="InterPro:IPR028909" /db_xref="InterPro:IPR036164" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10333" /db_xref="UniProtKB/Swiss-Prot:P26908" /translation="MYAIIKTGGKQIKVEEGQTVYIEKLAAEAGETVTFEDVLFVGGD NVKVGNPTVEGATVTAKVEKQGRAKKITVFRYKPKKNVHKKQGHRQPYTKVTIEKINA *" /label="rplU CDS" gene complement(2361932..2362240) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /label="rplU gene" misc_RNA complement(2362254..2362329) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /product="ribosomal protein L21 leader mRNA sequence" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27381917" /label="ldlU RNA" gene complement(2362254..2362329) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /label="ldlU gene" promotor_-10 complement(2362341..2362360) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2362361) /Source="Nicolas_upshifts" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2362374..2362381) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2362387..2363253) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /EC_number="3.4.24.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease [proteolysis of pro-sigma(K)]" /protein_id="NP_390675.1" /db_xref="EnsemblGenomes-Gn:BSU27970" /db_xref="EnsemblGenomes-Tr:CAB14757" /db_xref="GOA:P26937" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG10332" /db_xref="UniProtKB/Swiss-Prot:P26937" /translation="MNKWLDLILKIHVHPFLWIIAALGLLTGHMKALLCLLLIVLIHE LGHAALAVFFSWRIKRVFLLPFGGTVEVEEHGNRPLKEEFAVIIAGPLQHIWLQFAAW MLAEVSVIHQHTFELFTFYNLSILFVNLLPIWPLDGGKLLFLLFSKQLPFQKAHRLNL KTSLCFCLLLGCWVLFVIPLQISAWVLFVFLAVSLFEEYRQRHYIHVRFLLERYYGKN RELEKLLPLTVKAEDKVYHVMAEFKRGCKHPIIIEKSGQKLSQLDENEVLHAYFADKR TNSSMEELLLPY*" /label="spoIVFB CDS" gene complement(2362387..2363253) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /label="spoIVFB gene" CDS complement(2363246..2364040) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpoIVFB (stage IV sporulation)" /protein_id="NP_390676.1" /db_xref="EnsemblGenomes-Gn:BSU27980" /db_xref="EnsemblGenomes-Tr:CAB14758" /db_xref="GOA:P26936" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG10331" /db_xref="UniProtKB/Swiss-Prot:P26936" /translation="MSHRADEIRKRLEKRRKQLSGSKRFSTQTVSEKQKPPSWVMVTD QEKHGTLPVYEDNMPTFNGKHPLVKTDSIILKCLLSACLVLVSAIAYKTNIGPVSQIK PAVAKTFETEFQFASASHWFETKFGNPLAFLAPEHKNKEQQIEVGKDLIAPASGKVQQ DFQDNGEGIKVETSSDKIDSVKEGYVVEVSKDSQTGLTVKVQHADNTYSIYGELKDVD VALYDFVDKGKKLGSIKLDDHNKGVYYFAMKDGDKFIDPIQVISFE*" /label="spoIVFA CDS" gene complement(2363246..2364040) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /label="spoIVFA gene" downshifts 2364043 /Source="Nicolas_upshifts" /id="D1432" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="1.00279" /MaxDrop="2.6024" /score="-6.66807377" /energy="-6.9" /TU="NA" /idTUdmin="U2165" /TUdmin="-131" /isTUend="FALSE" /label="downshifts" promotor_no_box 2364049..2364149 /Source="Nicolas_upshift_promotors" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(2364064..2364082) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-10" upshifts complement(2364075) /Source="Nicolas_upshifts" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="upshifts" promotor_-35 complement(2364098..2364103) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-35" upshifts 2364109 /Source="Nicolas_upshifts" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2364152 /Source="Nicolas_upshifts" /id="D1433" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="1.68429" /MaxDrop="7.01891" /score="-6.66807377" /energy="-6.9" /TU="U2165" /idTUdmin="U2165" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts complement(2364187) /Source="Nicolas_upshifts" /id="D1434" /incds=0 /nref=236 /ntot=262 /MaxReadThrough="2.68001" /MaxDrop="5.80551" /score="40.3102023" /energy="-12.6" /TU="U2166" /idTUdmin="U2167" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2364190..2364996) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATPase activator of MinC" /protein_id="NP_390677.1" /db_xref="EnsemblGenomes-Gn:BSU27990" /db_xref="EnsemblGenomes-Tr:CAB14759" /db_xref="GOA:Q01464" /db_xref="InterPro:IPR002586" /db_xref="InterPro:IPR010223" /db_xref="InterPro:IPR025501" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10330" /db_xref="UniProtKB/Swiss-Prot:Q01464" /translation="MGEAIVITSGKGGVGKTTTSANLGTALAILGKRVCLVDTDIGLR NLDVVMGLENRIIYDLVDVVEGRCKMHQALVKDKRFDDLLYLMPAAQTSDKTAVAPEQ IKNMVQELKQEFDYVIIDCPAGIEQGYKNAVSGADKAIVVTTPEISAVRDADRIIGLL EQEENIEPPRLVVNRIRNHLMKNGDTMDIDEIVQHLSIDLLGIVADDDEVIKASNHGE PIAMDPKNRASIAYRNIARRILGESVPLQVLEEQNKGMMAKIKSFFGVRS*" /label="minD CDS" gene complement(2364190..2364996) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /label="minD gene" CDS complement(2364998..2365678) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division regulator (septum placement)" /protein_id="NP_390678.1" /db_xref="EnsemblGenomes-Gn:BSU28000" /db_xref="EnsemblGenomes-Tr:CAB14760" /db_xref="GOA:Q01463" /db_xref="InterPro:IPR005526" /db_xref="InterPro:IPR013033" /db_xref="InterPro:IPR036145" /db_xref="PDB:2M4I" /db_xref="SubtiList:BG10329" /db_xref="UniProtKB/Swiss-Prot:Q01463" /translation="MKTKKQQYVTIKGTKNGLTLHLDDACSFDELLDGLQNMLSIEQY TDGKGQKISVHVKLGNRFLYKEQEEQLTELIASKKDLFVHSIDSEVITKKEAQQIREE AEIISVSKIVRSGQVLQVKGDLLLIGDVNPGGTVRAGGNIFVLGSLKGIAHAGFNGNN QAVIAASEMLPTQLRINHVLNRSPDHIQKGNEMECAYLDTDGNMVIERLQHLAHLRPD LTRLEGGM*" /label="minC CDS" gene complement(2364998..2365678) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /label="minC gene" CDS complement(2365731..2366249) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 18156271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 18156271; Product type s: structure" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390679.1" /db_xref="EnsemblGenomes-Gn:BSU28010" /db_xref="EnsemblGenomes-Tr:CAB14761" /db_xref="GOA:Q01467" /db_xref="InterPro:IPR007227" /db_xref="SubtiList:BG10328" /db_xref="UniProtKB/Swiss-Prot:Q01467" /translation="MKRFLLPFVMMLVFSAESIFTDLVHFPFVTDDQVLAPRFLMLVL IFMSAFINQKHAMIYGFIFGFLYDMNYTSLLGVYMFGFAGLCYLASKAFKVLHTNAFV VILIAVLAVCLLEFYVFGIQSLIHKDIMTFNGFVLDRFIPTILLNIAAALILVLPFRL FFMSLKKELRDE*" /label="mreD CDS" gene complement(2365731..2366249) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /label="mreD gene" CDS complement(2366246..2367118) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 17427287, 20623345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 17427287, 20623345; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390680.2" /db_xref="EnsemblGenomes-Gn:BSU28020" /db_xref="EnsemblGenomes-Tr:CAB14762" /db_xref="GOA:Q01466" /db_xref="InterPro:IPR007221" /db_xref="SubtiList:BG10327" /db_xref="UniProtKB/Swiss-Prot:Q01466" /translation="MPNKRLMLLLLCIIILVAMIGFSLKGGRNTTWPEKVIGDTTGVF QNIFHTPAEFFAGIFENINDLKNTYKENERLREKLDGQTQYEAKLQELEEENKSLRDE LGHVKSIKDYKPILATVIARSPDNWAKQVTINKGTQQNVAKDMAVTNEKGALIGKIKS SGLNNFTSAVQLLSDTDRNNRVATKISGKKGSKGYGLIEGYDKEKKRLKMTIIERKDK QDVKKGDLIETSGTGGVFPEGLTIGEVTDIESDSYGLTKVAYVKPAADLTDLNNVIVV NRDVPTVDTEEEGS*" /label="mreC CDS" gene complement(2366246..2367118) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /label="mreC gene" CDS complement(2367149..2368162) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390681.2" /db_xref="EnsemblGenomes-Gn:BSU28030" /db_xref="EnsemblGenomes-Tr:CAB14763" /db_xref="GOA:Q01465" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10326" /db_xref="UniProtKB/Swiss-Prot:Q01465" /translation="MFGIGARDLGIDLGTANTLVFVKGKGIVVREPSVVALQTDTKSI VAVGNDAKNMIGRTPGNVVALRPMKDGVIADYETTATMMKYYINQAIKNKGMFARKPY VMVCVPSGITAVEERAVIDATRQAGARDAYPIEEPFAAAIGANLPVWEPTGSMVVDIG GGTTEVAIISLGGIVTSQSIRVAGDEMDDAIINYIRKTYNLMIGDRTAEAIKMEIGSA EAPEESDNMEIRGRDLLTGLPKTIEITGKEISNALRDTVSTIVEAVKSTLEKTPPELA ADIMDRGIVLTGGGALLRNLDKVISEETKMPVLIAEDPLDCVAIGTGKALEHIHLFKG KTR*" /label="mreB CDS" gene complement(2367149..2368162) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /label="mreB gene" upshifts complement(2368203) /Source="Nicolas_upshifts" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2368215..2368233) /Source="Nicolas_upshift_promotors" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2368254..2368949) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10652786, 17434969, 18556794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved nucleotide-related metabolism protein" /protein_id="NP_390682.1" /db_xref="EnsemblGenomes-Gn:BSU28040" /db_xref="EnsemblGenomes-Tr:CAB14764" /db_xref="GOA:Q02170" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR001405" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR020891" /db_xref="InterPro:IPR025657" /db_xref="SubtiList:BG10325" /db_xref="UniProtKB/Swiss-Prot:Q02170" /translation="MVIHDLPLKLKDFPMKEKPRERLLKVGAENLANHELLAILLRTG TKHESVLDLSNRLLRSFDGLRLLKEASVEELSSIPGIGMVKAIQILAAVELGSRIHKL ANEEHFVIRSPEDGANLVMEDMRFLTQEHFVCLYLNTKNQVIHKRTVFIGSLNSSIVH PREVFKEAFKRSAASFICVHNHPSGDPTPSREDIEVTRRLFECGNLIGIELLDHLVIG DKKFVSLKEKGYL*" /label="ysxA CDS" gene complement(2368254..2368949) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /label="ysxA gene" CDS complement(2368986..2369555) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /EC_number="3.6.1.9" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10841541, 16216582, 21564336, 24210219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10841541, 16216582, 21564336, 24210219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside triphosphate pyrophosphatase; septum formation DNA-binding protein (multicopy associated filamentation)" /protein_id="NP_390683.1" /db_xref="EnsemblGenomes-Gn:BSU28050" /db_xref="EnsemblGenomes-Tr:CAB14765" /db_xref="GOA:Q02169" /db_xref="InterPro:IPR003697" /db_xref="InterPro:IPR029001" /db_xref="PDB:1EX2" /db_xref="PDB:1EXC" /db_xref="PDB:4HEB" /db_xref="SubtiList:BG10324" /db_xref="UniProtKB/Swiss-Prot:Q02169" /translation="MTKPLILASQSPRRKELLDLLQLPYSIIVSEVEEKLNRNFSPEE NVQWLAKQKAKAVADLHPHAIVIGADTMVCLDGECLGKPQDQEEAASMLRRLSGRSHS VITAVSIQAENHSETFYDKTEVAFWSLSEEEIWTYIETKEPMDKAGAYGIQGRGALFV KKIDGDYYSVMGLPISKTMRALRHFDIRA*" /label="maf CDS" gene complement(2368986..2369555) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /label="maf gene" promotor_-10 complement(2369407..2369422) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2369416) /Source="Nicolas_upshifts" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2369435..2369444) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2369594..2369613) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2369610) /Source="Nicolas_upshifts" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2369627..2369633) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2369706) /Source="Nicolas_upshifts" /id="D1435" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="1.92542" /MaxDrop="5.77117" /score="8.94061802" /energy="-7.4" /TU="NA" /idTUdmin="U2169" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2369708..2370706) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16959571, 17376078, 22720735, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16959571, 17376078, 22720735, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spatial and temporal regulator of the dissolution of septal peptidoglycan during engulfment (stage II sporulation)" /protein_id="NP_390684.1" /db_xref="EnsemblGenomes-Gn:BSU28060" /db_xref="EnsemblGenomes-Tr:CAB14766" /db_xref="GOA:P37575" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="SubtiList:BG10912" /db_xref="UniProtKB/Swiss-Prot:P37575" /translation="MKKRKNKKNSKAAEKALKVTINGKEETVYEQETPETEANKSMTF SNWEEKRQAEQEVAASQEHPDEDEFNWDSEEDKVFKEDPKVVPPFQKKKTKLYAKGKT GAAKPVKRVAATIAFAAVIGTGLGLFALNISGNKEASAPASLEDSLGSQTAKAGDTSA DKQTSGAEKQAAQTEGTYKTYAVQAGKFSNEKGAETLTEQLTEKGYSAVSLSKDDGYT YVIAGLASEKEVSQQLGQVLIDSDFEAWGGKELSLSIESDMTDSFKETAELAAKAILD EDITKASVEKIEKSLGETKASETGEKKAILQALKELEDPSAEAGWKAQQELLAVVK*" /label="spoIIB CDS" gene complement(2369708..2370706) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /label="spoIIB gene" promotor_-10 complement(2370753..2370772) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2370761) /Source="Nicolas_upshifts" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2370784..2370791) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2370829) /Source="Nicolas_upshifts" /id="D1436" /incds=0 /nref=1 /ntot=56 /MaxReadThrough="3.18314" /MaxDrop="2.89774" /score="11.209969" /energy="-7.6" /TU="U2170" /idTUdmin="U2170" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS complement(2370840..2371586) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /EC_number="3.4.23.43" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2553669, 9723928, 15849754, 16751195, 16850406, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2553669, 9723928, 15849754, 16751195, 16850406, 16751195; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane prepilin peptidase" /protein_id="NP_390685.2" /db_xref="EnsemblGenomes-Gn:BSU28070" /db_xref="EnsemblGenomes-Tr:CAB14767" /db_xref="GOA:P15378" /db_xref="InterPro:IPR000045" /db_xref="InterPro:IPR010627" /db_xref="SubtiList:BG10323" /db_xref="UniProtKB/Swiss-Prot:P15378" /translation="MLSILFIFGLILGSFYYTAGCRIPLHLSIIAPRSSCPFCRRTLT PAELIPILSFLFQKGKCKSCGHRISFMYPAAELVTACLFAAAGIRFGISLELFPAVVF ISLLIIVAVTDIHFMLIPNRILIFFLPFLAAARLISPLDSWYAGLLGAAAGFLFLAVI AAITHGGVGGGDIKLFAVIGFVLGVKMLAAAFFFSVLIGALYGAAAVLTGRLAKRQPL PFAPAIAAGSILAYLYGDSIISFYIKMALG*" /label="comC CDS" gene complement(2370840..2371586) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /label="comC gene" promotor_-10 complement(2371614..2371633) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2371621) /Source="Nicolas_upshifts" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2371648..2371655) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2371726..2373018) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /EC_number="6.3.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2105929, 2985605, 3040739, 6994831, 9098041, 15705579, 22720735, 26443588; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="folyl-polyglutamate synthase" /protein_id="NP_390686.1" /db_xref="EnsemblGenomes-Gn:BSU28080" /db_xref="EnsemblGenomes-Tr:CAB14768" /db_xref="GOA:Q05865" /db_xref="InterPro:IPR001645" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR018109" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10322" /db_xref="UniProtKB/Swiss-Prot:Q05865" /translation="MFTAYQDARSWIHGRLKFGVKPGLGRMKQLMARLGHPEKKIRAF HVAGTNGKGSTVAFIRSMLQEAGYTVGTFTSPYIITFNERISVNGIPISDEEWTALVN QMKPHVEALDQTEYGQPTEFEIMTACAFLYFAEFHKVDFVIFETGLGGRFDSTNVVEP LLTVITSIGHDHMNILGNTIEEIAGEKAGIIKEGIPIVTAVTQPEALQVIRHEAERHA APFQSLHDACVIFNEEALPAGEQFSFKTEEKCYEDIRTSLIGTHQRQNAALSILAAEW LNKENIAHISDEALRSGLVKAAWPGRLELVQEHPPVYLDGAHNEEGVEKLAETMKQRF ANSRISVVFSALKDKPYQNMIKRLETIAHAIHFASFDFPRASLAKDLYDASEISNKSW SEDPDDVIKFIESKKGSNEIVLITGSLYFISDIRKRLK*" /label="folC CDS" gene complement(2371726..2373018) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /label="folC gene" downshifts complement(2371731) /Source="Nicolas_upshifts" /id="D1437" /incds=0 /nref=1 /ntot=121 /MaxReadThrough="1.66565" /MaxDrop="3.18428" /score="24.7086033" /energy="-14.3" /TU="NA" /idTUdmin="U2171" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2373019..2373077) /Source="Nicolas_S_feature" /locus_tag="new_2866605_2866663_c" /HighExp="S0, LBGexp, G150, MG 45, G135, G180, Gly, Oxctl, M0t45, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1060" CDS complement(2373078..2375720) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /EC_number="6.1.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9098041, 11114335, 25310979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 11114335, 25310979; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="valyl-tRNA synthetase" /protein_id="NP_390687.2" /db_xref="EnsemblGenomes-Gn:BSU28090" /db_xref="EnsemblGenomes-Tr:CAB14769" /db_xref="GOA:Q05873" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002303" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR019499" /db_xref="InterPro:IPR033705" /db_xref="InterPro:IPR037118" /db_xref="SubtiList:BG10321" /db_xref="UniProtKB/Swiss-Prot:Q05873" /translation="METNEQTMPTKYDPAAVEKDRYDFWLKGKFFEAGSDQTKEPYSV VIPPPNVTGRLHLGHAWDTTLQDIVTRMKRMQGYDVLWLPGMDHAGIATQAKVEAKLR EEGKSRYDLGREKFLEETWKWKEEYADFIRSQWAKLGLGLDYSRERFTLDEGLSKAVR EVFVKLYEKGLIYRGEYIINWDPATKTALSDIEVIYKDVQGAFYHMSYPLADGSGSIE IATTRPETMLGDTAVAVHPEDERYKHLIGKTVILPIVNREIPIVGDDYVDMEFGSGAV KITPAHDPNDFELGNRHNLERILVMNEDGTMNENALQYQGMDRFECRKKLVKDLQEAG VLFKIEDHMHSVGHSERSGAVVEPYLSTQWFVRMQPLADAAIELQKKEEKVNFVPDRF EKTYLHWMENIRDWCISRQLWWGHRIPAWYHKETGELYVGLEAPEDSENWEQDTDVLD TWFSSALWPFSTMGWPDVTAEDFKRYYPTDVLVTGYDIIFFWVSRMIFQGIEFTGERP FKDVLIHGLIRDEQGRKMSKSLGNGVDPMDVIDKYGADSLRYFLATGSSPGQDLRFSY EKVESTWNFANKIWNASRFALMNMDGMTYDELDLSGEKSVADKWILTRLNETIEHVTQ LADRYEFGEVGRHLYNFIWDDFCDWYIEMAKLPLYGEDEAAKKTTRSILAYVLDQTMR LLHPFMPFLTEEIWQHLPHQGESITVSQWPAVVPEHTDTEAAADMKLLVELIRSVRNI RSEVNTPMSKQVELYIKTSTDEIASRLEANRSYVERFTNPSVLKIGTDIEAVDKAMTA VVSGAEVILPLEGLINIDEEIARLQKEFDKLTKEVERVQKKLGNEGFMKKAPAHVIDE EREKEKDYVAKRDAVQKRMAELKG*" /label="valS CDS" gene complement(2373078..2375720) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /label="valS gene" S_feature complement(2375721..2375779) /Source="Nicolas_S_feature" /locus_tag="new_2869307_2869365_c" /HighExp="G150, G180, LBGexp, Oxctl, G135, dia0, HPh, Lbexp, Paraq, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigEF" /TUshortPSig="1, 0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1061" misc_RNA complement(2375780..2376002) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /product="T-box riboswitch specific of valine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboV RNA" gene complement(2375780..2376002) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /label="tboV gene" downshifts complement(2375823) /Source="Nicolas_upshifts" /id="D1438" /incds=0 /nref=9 /ntot=27 /MaxReadThrough="6.76593" /MaxDrop="4.53149" /score="23.9897385" /energy="-20" /TU="U2171,U2173,U2176" /idTUdmin="U2176" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2376031..2376050) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2376043) /Source="Nicolas_upshifts" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2376045..2376153) /Source="Nicolas_S_feature" /locus_tag="new_2869631_2869739_c" /HighExp="S8, S6, S7, S5, B36, LoTm, S4, S3, BT, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigEF" /TUshortPSig="0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1062" promotor_-35 complement(2376065..2376070) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2376107..2376116 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2376129..2376148 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2376130 /Source="Nicolas_upshifts" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2376146..2376160) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2376153) /Source="Nicolas_upshifts" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2376168..2376172) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2376168..2376359 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097770.1" /db_xref="EnsemblGenomes-Gn:BSU28099" /db_xref="EnsemblGenomes-Tr:CAX52676" /db_xref="GOA:C0H465" /db_xref="UniProtKB/Swiss-Prot:C0H465" /translation="MKKRFSSYSLPPWVRQIRLVSAQVIIPITIFQGIRTIFFPTTFD VLLLAILIFLACALHLEWI*" /label="yszA CDS" gene 2376168..2376359 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /label="yszA gene" CDS complement(2376378..2377403) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16371471, 16390444, 22091839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16371471, 16390444, 22091839; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390688.1" /db_xref="EnsemblGenomes-Gn:BSU28100" /db_xref="EnsemblGenomes-Tr:CAB14770" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014253" /db_xref="SubtiList:BG10347" /db_xref="UniProtKB/Swiss-Prot:P37964" /translation="MEDTQSVLQEYGLTAQFIEPVSPLVWKVYTDYGIFALKKLKEGR GKHFTDHMVAIEEKGFRSFVPVYRTNSGEFFSAGIQYGDIYYLMPWLQFDQEEERDQK HAYLFRETARLHERTAQELKVRRDEIERYYGQTKKKWEQDKIFYEQFVDRAEKEWYLS PFELQAITYFSETISAVNFALERLEDWYESAKEKDVSRVVMNHGSLSIHHFLYNDAGT GYFTNFERASVGPPQNDLLGFYTKMFRGFPKACPECVEWFYGYTKSFPLREAEVSLFL SYMAYPAAMYKVLNGYQTGKRQHEKEECTQLLKAYWQMKNIEPFVMKIHQIEQEKKFQ AENESTS*" /label="cotN CDS" gene complement(2376378..2377403) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /label="cotN gene" downshifts complement(2376408) /Source="Nicolas_upshifts" /id="D1439" /incds=0 /nref=23 /ntot=70 /MaxReadThrough="4.44965" /MaxDrop="6.68961" /score="-7.46388093" /energy="-12.1" /TU="U2176" /idTUdmin="U2176" /TUdmin="-1311" /isTUend="FALSE" /label="downshifts" CDS complement(2377436..2379163) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11325931, 16371471, 16950916, 22773792, 23178679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325931, 16371471, 16950916, 22773792, 23178679; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenetic spore protein (stage VI sporulation)" /protein_id="NP_390689.1" /db_xref="EnsemblGenomes-Gn:BSU28110" /db_xref="EnsemblGenomes-Tr:CAB14771" /db_xref="GOA:P37963" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10346" /db_xref="UniProtKB/Swiss-Prot:P37963" /translation="MPQNHRLQFSVEESICFQKGQEVSELLSISLDPDIRVQEVNDYV SIIGSLELTGEYNIDQNKHTEEIYTDKRFVEQVRKREDGSAELTHCFPVDITIPKNKV SHLQDVFVFIDAFDYQLTDSRILTIQADLAIEGLLDDTQDKEPEIPLYEAPAAFREEE LSEPPAHSVVEEPGASSAEEAVLQHEPPAEPPELFISKAGLREELETEKAESEPPESV ASEPEAREDVKEEEESEELAVPETEVRAESETEESEPEPDPSEIEIQEIVKAKKETAE PAAAIADVREEADSPAETELREHVGAEESPALEAELHSETVIAKEKEETTVSPNHEYA LRQEAQNEEAAQSDQADPALCQEEAEPDEALESVSEAALSIEDSRETASAVYMENDNA DLHFHFNQKTSSEEASQEELPEPAYRTFLPEQEEEDSFYSAPKLLEEEEQEEESFEIE VRKTPSAEEPKEETPFQSFQLPESSETERKETDAVPRVAPAAETKEPQTKESDNSLYL TKLFTKEADEFSRMKICIVQQEDTIERLCERYEITSQQLIRMNSLALDDELKAGQILY IPQYKNSHA*" /label="spoVID CDS" gene complement(2377436..2379163) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /label="spoVID gene" promotor_-35 2378765..2378768 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2378784..2378803 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2378790 /Source="Nicolas_upshifts" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2379159..2379163 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2379172..2379186 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2379186 /Source="Nicolas_upshifts" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2379201..2379219) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-10" upshifts complement(2379217) /Source="Nicolas_upshifts" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="upshifts" promotor_-35 complement(2379235..2379240) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-35" CDS complement(2379294..2380586) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 12029044, 15802251, 16682782, 20946885, 27303897" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 12029044, 15802251, 16682782, 20946885, 27303897; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde 2,1-aminomutase" /protein_id="NP_390690.1" /db_xref="EnsemblGenomes-Gn:BSU28120" /db_xref="EnsemblGenomes-Tr:CAB14772" /db_xref="GOA:P30949" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3BS8" /db_xref="SubtiList:BG10345" /db_xref="UniProtKB/Swiss-Prot:P30949" /translation="MRSYEKSKTAFKEAQKLMPGGVNSPVRAFKSVDMDPIFMERGKG SKIFDIDGNEYIDYVLSWGPLILGHTNDRVVESLKKVAEYGTSFGAPTEVENELAKLV IDRVPSVEIVRMVSSGTEATMSALRLARGYTGRNKILKFEGCYHGHGDSLLIKAGSGV ATLGLPDSPGVPEGIAKNTITVPYNDLESVKLAFQQFGEDIAGVIVEPVAGNMGVVPP QEGFLQGLRDITEQYGSLLIFDEVMTGFRVDYNCAQGYFGVTPDLTCLGKVIGGGLPV GAYGGKAEIMEQIAPSGPIYQAGTLSGNPLAMTAGLETLKQLTPESYKNFIKKGDRLE EGISKTAGAHGIPHTFNRAGSMIGFFFTNEPVINYETAKSSDLKLFASYYKGMANEGV FLPPSQFEGLFLSTAHTDEDIENTIQAAEKVFAEISRR*" /label="hemL CDS" gene complement(2379294..2380586) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /label="hemL gene" downshifts complement(2379311) /Source="Nicolas_upshifts" /id="D1440" /incds=0 /nref=144 /ntot=397 /MaxReadThrough="3.40168" /MaxDrop="7.29251" /score="3.77738386" /energy="-10.6" /TU="NA" /idTUdmin="U2177" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2380616..2381590) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /EC_number="4.2.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 12029044, 15802251, 20823524, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 12029044, 15802251, 20823524, 24598743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-aminolevulinic acid dehydratase (porphobilinogen synthase)" /protein_id="NP_390691.1" /db_xref="EnsemblGenomes-Gn:BSU28130" /db_xref="EnsemblGenomes-Tr:CAB14773" /db_xref="GOA:P30950" /db_xref="InterPro:IPR001731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR030656" /db_xref="SubtiList:BG10344" /db_xref="UniProtKB/Swiss-Prot:P30950" /translation="MSQSFNRHRRLRTSKAMREMVKETRLHPSDFIYPIFVVEGLEGK KAVPSMPDVHHVSLDLLKDEVAELVKLGIQSVIVFGIPEEKDDCGTQAYHDHGIVQKA ITEIKEHFPEMVVVADTCLCEYTDHGHCGLVKDGVILNDESLELLAQTAVSQAKAGAD IIAPSNMMDGFVTVIREALDKEGFVNIPIMSYAVKYSSEFYGPFRDAANSTPQFGDRK TYQMDPANRMEALREAQSDVEEGADFLIVKPSLSYMDIMRDVKNEFTLPLVAYNVSGE YSMVKAAAQNGWIKEKEIVLEILTSMKRAGADLIITYHAKDAAKWLAE*" /label="hemB CDS" gene complement(2380616..2381590) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /label="hemB gene" CDS complement(2381587..2382375) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /EC_number="4.2.1.75" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 2110138, 7628476, 12029044, 12196144, 15802251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 2110138, 7628476, 12029044, 12196144, 15802251; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III cosynthase" /protein_id="NP_390692.1" /db_xref="EnsemblGenomes-Gn:BSU28140" /db_xref="EnsemblGenomes-Tr:CAB14774" /db_xref="GOA:P21248" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG10343" /db_xref="UniProtKB/Swiss-Prot:P21248" /translation="MENDFPLKGKTVLVTRNKAQAASFQQKVEALGGKAVLTSLITFR RALPNDVAEQVREDLAAPGWLVFTSVNGADFFFSYLKENQLILPAHKKIAAVGEKTAR RLKMHNVSVDVMPQEYIAEQLADALKQHAEPGETITVMKGNLSRDVIKQELVPLGFEV KEWVLYETIPDEEGIEALKDAAGQYSFDYVTFTSSSTVHTFMHVLGEELKKWKANGTA CISIGPLTNDALLTYGITSHTPDTFTIDGMLELMCSMSREEERI*" /label="hemD CDS" gene complement(2381587..2382375) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /label="hemD gene" CDS complement(2382365..2383309) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /EC_number="2.5.1.61" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 9058548, 12029044, 15802251, 23908040, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 9058548, 12029044, 15802251, 23908040, 24598743; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="porphobilinogen deaminase (hydroxymethylbilane synthase)" /protein_id="NP_390693.1" /db_xref="EnsemblGenomes-Gn:BSU28150" /db_xref="EnsemblGenomes-Tr:CAB14775" /db_xref="GOA:P16616" /db_xref="InterPro:IPR000860" /db_xref="InterPro:IPR022417" /db_xref="InterPro:IPR022418" /db_xref="InterPro:IPR022419" /db_xref="InterPro:IPR036803" /db_xref="SubtiList:BG10342" /db_xref="UniProtKB/Swiss-Prot:P16616" /translation="MMRTIKVGSRRSKLAMTQTKWVIQKLKEINPSFAFEIKEIVTKG DRIVDVTLSKVGGKGLFVKEIEQALLNEEIDMAVHSMKDMPAVLPEGLVIGCIPERED PRDALISKNRVKLSEMKKGAVIGTSSLRRSAQLLIERPDLTIKWIRGNIDTRLQKLET EDYDAIILAAAGLSRMGWKQDVVTEFLEPERCLPAVGQGALAIECRESDEELLALFSQ FTDEYTKRTVLAERAFLNAMEGGCQVPIAGYSVLNGQDEIEMTGLVASPDGKIIFKET VTGNDPEEVGKRCAALMADKGAKDLIDRVKRELDEDGK*" /label="hemC CDS" gene complement(2382365..2383309) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /label="hemC gene" CDS complement(2383342..2384172) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8012594, 12029044, 15802251, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012594, 12029044, 15802251, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="negative effector of the concentration of glutamyl-tRNA reductase HemA" /protein_id="NP_390694.2" /db_xref="EnsemblGenomes-Gn:BSU28160" /db_xref="EnsemblGenomes-Tr:CAB14776" /db_xref="GOA:P16645" /db_xref="InterPro:IPR002541" /db_xref="SubtiList:BG10341" /db_xref="UniProtKB/Swiss-Prot:P16645" /translation="MIDTAMARLNEGTIVIYALSVLFYFIDFLQHNRKAGKMAFWLLS IVWTLQTVYLAYFMWVTGRFPVLNVTEALYFYAWVLVTLSLVLTKLLRVDFIVFFTNV IGFSMIAIHTFSPTEQQSAAFSGQLVSELLVIHITMAILSYGAFSLSFVFSVLYMFQY HLLKKKKWGKWLLRIEDLSKLDYMAYVLNVIGVPMLLLSLILGVIWAYVSLETLYWFD AKVLGSFVVLLLYSYYLYIRLIKELQGKVAALWNTACFLVLMINYFLLGSLSQFHWFS *" /label="hemX CDS" gene complement(2383342..2384172) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /label="hemX gene" CDS complement(2384180..2385547) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /EC_number="1.2.1.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1536660, 15802251, 1672867, 2490162, 12029044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1536660, 15802251, 1672867, 2490162, 12029044; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA reductase" /protein_id="NP_390695.1" /db_xref="EnsemblGenomes-Gn:BSU28170" /db_xref="EnsemblGenomes-Tr:CAB14777" /db_xref="GOA:P16618" /db_xref="InterPro:IPR000343" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR015895" /db_xref="InterPro:IPR015896" /db_xref="InterPro:IPR018214" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036343" /db_xref="InterPro:IPR036453" /db_xref="SubtiList:BG10340" /db_xref="UniProtKB/Swiss-Prot:P16618" /translation="MHILVVGVDYKSAPIEIREKVSFQPNELAEAMVQLKEEKSILEN IIVSTCNRTEIYAVVDQLHTGRYYIKKFLADWFQLSKEELSPFLTFYESDAAVEHLFR VACGLDSMVIGETQILGQVRDSFKTAQQEKTIGTIFNELFKQAVTVGKRTHAETDIGS NAVSVSYAAVELAKKIFGNLSSKHILILGAGKMGELAAENLHGQGIGKVTVINRTYLK AKELADRFSGEARSLNQLESALAEADILISSTGASEFVVSKEMMENANKLRKGRPLFM VDIAVPRDLDPALNDLEGVFLYDIDDLEGIVEANMKERRETAEKVELLIEETIVEFKQ WMNTLGVVPVISALREKALAIQSETMDSIERKLPHLSTREKKLLNKHTKSIINQMLRD PILKVKELAADADSEEKLALFMQIFDIEEAAGRQMMKTVESSQKVHSFKKAESKAGFS PLVSE*" /label="hemA CDS" gene complement(2384180..2385547) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /label="hemA gene" misc_feature complement(2385611..2385630) /Source="Nicolas_upshift_promotors" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2385617) /Source="Nicolas_upshifts" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2385619..2385708) /Source="Nicolas_S_feature" /locus_tag="new_2879205_2879294_c" /HighExp="dia15, Salt, dia5, Etha, Paraq, H2O2, Diami, Heat, LoTm, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigGF" /TUshortPSig="0.997, 1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1063" misc_feature 2385668..2385687 /Source="Nicolas_upshift_promotors" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2385676 /Source="Nicolas_upshifts" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2385705..2385724) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2385708) /Source="Nicolas_upshifts" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2385710..2386126) /Source="Nicolas_S_feature" /locus_tag="new_2879296_2879712_c" /HighExp="Etha, S5, Gly, S7, S4, S8, S6, H2O2, dia15, G135" /AntisenseName="ysxD" /AntisenseCor="-1.16761021676615E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF" /TUshortPSig="1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1064" promotor_-35 complement(2385735..2385743) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2385777..2386274 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390696.2" /db_xref="EnsemblGenomes-Gn:BSU28180" /db_xref="EnsemblGenomes-Tr:CAB14778" /db_xref="GOA:P40736" /db_xref="SubtiList:BG11068" /db_xref="UniProtKB/Swiss-Prot:P40736" /translation="MKQKSILFPCLLLAASVYAWLESGQAELFSGQDQWPVLLMLLGA AFVYQGKKEAVTPHFFIGLLLFGIGLHFFAKPKWVWWPDDFEMLLFMIGFSLLVSTVQ KKEYVYEAVSMICFSLFLYFFKQIMAWLESAHIPTALLKEYWPFVFIGISLLLLLIKR KKSIR*" /label="ysxD CDS" gene 2385777..2386274 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /label="ysxD gene" promotor_-10 complement(2386110..2386128) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2386126) /Source="Nicolas_upshifts" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2386128..2386258) /Source="Nicolas_S_feature" /locus_tag="new_2879714_2879844_c" /HighExp="S5, S4, S8, S6, H2O2, S7, Etha, dia15, Diami, G180" /AntisenseName="ysxD" /AntisenseCor="-1.18079537254433E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1065" promotor_-35 complement(2386144..2386150) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2386238..2386249) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-10" upshifts complement(2386258) /Source="Nicolas_upshifts" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="upshifts" promotor_-35 complement(2386264..2386270) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-35" CDS complement(2386296..2386883) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome 50S subunit assembly(maturation of the central 50S protuberance)" /protein_id="NP_390697.1" /db_xref="EnsemblGenomes-Gn:BSU28190" /db_xref="EnsemblGenomes-Tr:CAB14779" /db_xref="GOA:P38424" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019987" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030393" /db_xref="PDB:1SUL" /db_xref="PDB:1SVI" /db_xref="PDB:1SVW" /db_xref="SubtiList:BG10339" /db_xref="UniProtKB/Swiss-Prot:P38424" /translation="MKVTKSEIVISAVKPEQYPEGGLPEIALAGRSNVGKSSFINSLI NRKNLARTSSKPGKTQTLNFYIINDELHFVDVPGYGFAKVSKSEREAWGRMIETYITT REELKAVVQIVDLRHAPSNDDVQMYEFLKYYGIPVIVIATKADKIPKGKWDKHAKVVR QTLNIDPEDELILFSSETKKGKDEAWGAIKKMINR*" /label="engB CDS" gene complement(2386296..2386883) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /label="engB gene" downshifts complement(2386324) /Source="Nicolas_upshifts" /id="D1441" /incds=0 /nref=78 /ntot=212 /MaxReadThrough="4.03888" /MaxDrop="6.16077" /score="19.8235959" /energy="-13.4" /TU="NA" /idTUdmin="U2182" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2386880..2389204) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /EC_number="3.4.21.53" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="class III heat-shock ATP-dependent LonA protease" /protein_id="NP_390698.1" /db_xref="EnsemblGenomes-Gn:BSU28200" /db_xref="EnsemblGenomes-Tr:CAB14780" /db_xref="GOA:P37945" /db_xref="InterPro:IPR003111" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004815" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027543" /db_xref="PDB:1X37" /db_xref="PDB:3M65" /db_xref="PDB:3M6A" /db_xref="SubtiList:BG10338" /db_xref="UniProtKB/Swiss-Prot:P37945" /translation="MAEELKRSIPLLPLRGLLVYPTMVLHLDVGRDKSVQALEQAMMH DHMIFLATQQDISIDEPGEDEIFTVGTYTKIKQMLKLPNGTIRVLVEGLKRAHIVKYN EHEDYTSVDIQLIHEDDSKDTEDEALMRTLLDHFDQYIKISKKISAETYAAVTDIEEP GRMADIVASHLPLKLKDKQDILETADVKDRLNKVIDFINNEKEVLEIEKKIGQRVKRS MERTQKEYYLREQMKAIQKELGDKEGKTGEVQTLTEKIEEAGMPDHVKETALKELNRY EKIPSSSAESSVIRNYIDWLVALPWTDETDDKLDLKEAGRLLDEEHHGLEKVKERILE YLAVQKLTKSLKGPILCLAGPPGVGKTSLAKSIAKSLGRKFVRISLGGVRDESEIRGH RRTYVGAMPGRIIQGMKKAGKLNPVFLLDEIDKMSSDFRGDPSSAMLEVLDPEQNSSF SDHYIEETFDLSKVLFIATANNLATIPGPLRDRMEIINIAGYTEIEKLEIVKDHLLPK QIKEHGLKKSNLQLRDQAILDIIRYYTREAGVRSLERQLAAICRKAAKAIVAEERKRI TVTEKNLQDFIGKRIFRYGQAETEDQVGVVTGLAYTTVGGDTLSIEVSLSPGKGKLIL TGKLGDVMRESAQAAFSYVRSKTEELGIEPDFHEKYDIHIHVPEGAVPKDGPSAGITM ATALVSALTGRAVSREVGMTGEITLRGRVLPIGGLKEKALGAHRAGLTTIIAPKDNEK DIEDIPESVREGLTFILASHLDEVLEHALVGEKK*" /label="lonA CDS" gene complement(2386880..2389204) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /label="lonA gene" S_feature complement(2389205..2389316) /Source="Nicolas_S_feature" /locus_tag="new_2882791_2882902_c" /HighExp="Etha, dia15, LBGtran, dia5, Diami, H2O2, LBGexp, Lbexp, LoTm, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.967" /TUlongSig="NA" /TUlongPSig="NA" /label="S1066" promotor_-10 complement(2389301..2389320) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2389316) /Source="Nicolas_upshifts" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2389334..2389341) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2389385..2391043) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 18689473, 26428922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 18689473, 26428922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific ATP-dependent protease LonB" /protein_id="NP_390699.1" /db_xref="EnsemblGenomes-Gn:BSU28210" /db_xref="EnsemblGenomes-Tr:CAB14781" /db_xref="GOA:P42425" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014251" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11077" /db_xref="UniProtKB/Swiss-Prot:P42425" /translation="MSWTGIALFIQLFFGIIIGLYFWNLLKNQRTQKVTIDKESKKEM EQLRKMRAISLSEPLSEKVRPKSFKDIVGQEDGIKALKAALCGPNPQHVIVYGPPGVG KTAAARLVLEEAKKHKQSPFKEQAVFVELDATTARFDERGIADPLIGSVHDPIYQGAG AMGQAGIPQPKQGAVTHAHGGVLFIDEIGELHPIQMNKMLKVLEDRKVFLDSAYYSEE NTQIPNHIHDIFQNGLPADFRLIGATTRMPNEIPPAIRSRCLEVFFRELEKDELKTVA KTAADKIEKNISEEGLDLLTSYTRNGREAVNMIQIAAGMAVTENRKDITIEDIEWVIH SSQLTPKHEQKIGVEPQVGIVNGLAVYGPNSGSLLEIEVSVTAAQDKGSINITGIAEE ESIGSQSKSIRRKSMAKGSVENVLTVLRTMGMKPSDYDIHINFPGGIPIDGPSAGIAM AAGIFSAIHKIPIDNTVAMTGEISLNGLVKPIGGVIPKIKAAKQSGAKKVIIPYENQQ AILKQIDGIEIIAVKTFQEVLDEILVNPPTEQKPFHIEINKESV*" /label="lonB CDS" gene complement(2389385..2391043) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /label="lonB gene" downshifts complement(2389404) /Source="Nicolas_upshifts" /id="D1442" /incds=0 /nref=24 /ntot=42 /MaxReadThrough="2.32825" /MaxDrop="4.82102" /score="7.30551887" /energy="-7.1" /TU="NA" /idTUdmin="U2183" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2391087..2391105) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2391098) /Source="Nicolas_upshifts" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2391121..2391126) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2391195..2392457) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein unfolding ATPase required for presentation of proteins to proteases; Maxwell's demon" /protein_id="NP_390700.2" /db_xref="EnsemblGenomes-Gn:BSU28220" /db_xref="EnsemblGenomes-Tr:CAB14782" /db_xref="GOA:P50866" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004487" /db_xref="InterPro:IPR010603" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11387" /db_xref="UniProtKB/Swiss-Prot:P50866" /translation="MFKFNEEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCTE IVEEELGTEEEVEFKDVPKPQEIREILNEYVIGQDQAKKSLAVAVYNHYKRINSNSKV DDVELSKSNISLIGPTGSGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENILL KLIQAADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVAS VPPQGGRKHPHQEFIQIDTTNILFICGGAFDGIEQIIKRRLGQKVIGFGADNKAADLE KEDLLSKVLPEDLLRFGLIPEFIGRLPVIASLEKLDEEALVAILTKPKNALVKQFKKM LELDNVELEFEEEALSEIAKKAIERKTGARGLRSIIEGIMLDVMFELPSRDDIEKCVI TGATVTHGEPPRLLLKDGTEVSQDKTSA*" /label="clpX CDS" gene complement(2391195..2392457) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /label="clpX gene" downshifts complement(2391205) /Source="Nicolas_upshifts" /id="D1443" /incds=0 /nref=256 /ntot=333 /MaxReadThrough="2.8818" /MaxDrop="7.82186" /score="40.299167" /energy="-18.9" /TU="U2185" /idTUdmin="U2184" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" S_feature complement(2392458..2392547) /Source="Nicolas_S_feature" /locus_tag="new_2886044_2886133_c" /HighExp="dia15, dia5, Salt, Diami, C90, H2O2, Paraq, Oxctl, S1, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="1, 0.998, 0.896" /label="S1067" promotor_-10 complement(2392535..2392554) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2392547) /Source="Nicolas_upshifts" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2392549..2392680) /Source="Nicolas_S_feature" /locus_tag="new_2886135_2886266_c" /HighExp="H2O2, dia15, Paraq, Oxctl, G180, G135, HPh, G150, LPh, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1068" promotor_-35 complement(2392566..2392573) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2392725) /Source="Nicolas_upshifts" /id="D1444" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="8.26501" /MaxDrop="4.34985" /score="-0.284489083" /energy="-10.7" /TU="U2185,U2190" /idTUdmin="U2190" /TUdmin="-153" /isTUend="FALSE" /label="downshifts" CDS complement(2392729..2394003) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9748346, 12224648, 16156784, 17021213" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9748346, 12224648, 16156784, 17021213; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl isomerase (trigger factor)" /protein_id="NP_390701.1" /db_xref="EnsemblGenomes-Gn:BSU28230" /db_xref="EnsemblGenomes-Tr:CAB14783" /db_xref="GOA:P80698" /db_xref="InterPro:IPR001179" /db_xref="InterPro:IPR005215" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR008881" /db_xref="InterPro:IPR027304" /db_xref="InterPro:IPR036611" /db_xref="SubtiList:BG19023" /db_xref="UniProtKB/Swiss-Prot:P80698" /translation="MSVKWEKQEGNEGVLTVEVDAETFKTALDDAFKKVVKQVSIPGF RKGKIPRGLFEQRFGVEALYQDALDILLPVEYPKAVEEAGIEPVDRPEIDVEKIEKGE SLIFTAKVTVKPEVKLGEYKGLGIEKDDTTVTDEDVQNELKALQERQAELVVKEEGAV EEGNTVVLDFEGFVDGEAFEGGKAENYSLEVGSGSFIPGFEDQLVGLEAGAEKDVEVT FPEEYHAEDLAGKPAVFKVKIHEIKAKELPELDDEFAKDIDEEVETLAELTEKTKKRL EEAKENEADAKLREELVLKASENAEIDVPQAMVDTELDRMLKEFEQRLQMQGMNLELY TQFSGQDEAALKEQMKEDAEKRVKSNLTLEAIAKAENLEVSDEEVDAELTKMAEAYNM PVENIKQAIGSTDAMKEDLKVRKAIDFLVENR*" /label="tig CDS" gene complement(2392729..2394003) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /label="tig gene" S_feature complement(2394004..2394193) /Source="Nicolas_S_feature" /locus_tag="new_2887590_2887779_c" /HighExp="H2O2, HPh, BMM, dia15, T-4.40H, G180, Paraq, Oxctl, LBGexp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1069" promotor_-10 complement(2394180..2394199) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2394193) /Source="Nicolas_upshifts" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2394214..2394218) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2394231..2395235) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390702.2" /db_xref="EnsemblGenomes-Gn:BSU28240" /db_xref="EnsemblGenomes-Tr:CAB14784" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12338" /db_xref="UniProtKB/Swiss-Prot:P94569" /translation="MTHDKKNAKIIPFPHLKDRLVEKGMSSLKEKKYQEALELFSEAM KYDDTESDLHLGMAICFLELGELEEAESVCEKMLKEGYGHYFTVLQVYMTILIQLKKY EEVKSTIEAVLEENQLPAESAEQFYKLLDFSRKMTDPDREDEAWAEEYEDTIDTEKVL ASPEEQMNLIHSLKDRNVAKYTGLLKTILQDPSAHPIIKTMIVMLLAEHEYSKPVHIS KFGESLTIEPSEIVPPDAAPILHRVLRVLDETLGNENPTLYAAVEELWRRHLYVLYPF QPKLLSADLWAAALHKVGYEMHGIEIESEELHMMYEFTDRELDEACTMLKDIEEISYL *" /label="ysoA CDS" gene complement(2394231..2395235) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /label="ysoA gene" promotor_-10 complement(2395260..2395279) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2395278) /Source="Nicolas_upshifts" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="upshifts" promotor_-35 complement(2395291..2395298) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" CDS complement(2395354..2395953) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (small subunit)" /protein_id="NP_390703.1" /db_xref="EnsemblGenomes-Gn:BSU28250" /db_xref="EnsemblGenomes-Tr:CAB14785" /db_xref="GOA:P94568" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR004431" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR033940" /db_xref="SubtiList:BG11950" /db_xref="UniProtKB/Swiss-Prot:P94568" /translation="MEPLKSHTGKAAVLNRINVDTDQIIPKQFLKRIERTGYGRFAFF DWRYDANGEPNPEFELNQPVYQGASILIAGENFGCGSSREHAPWALDDYGFKIIIAPS FADIFHQNCFKNGMLPIRMPYDNWKQLVGQYENQSLQMTVDLENQLIHDSEGNQISFE VDPHWKEMLINGYDEISLTLLLEDEIKQFESQRSSWLQA*" /label="leuD CDS" gene complement(2395354..2395953) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /label="leuD gene" downshifts complement(2395375) /Source="Nicolas_upshifts" /id="D1445" /incds=0 /nref=5 /ntot=111 /MaxReadThrough="6.76876" /MaxDrop="3.81278" /score="12.2084487" /energy="-9.9" /TU="U2190,U2191" /idTUdmin="U2186" /TUdmin="-1176" /isTUend="FALSE" /label="downshifts" CDS complement(2395966..2397384) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (large subunit)" /protein_id="NP_390704.1" /db_xref="EnsemblGenomes-Gn:BSU28260" /db_xref="EnsemblGenomes-Tr:CAB14786" /db_xref="GOA:P80858" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR004430" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR033941" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG11949" /db_xref="UniProtKB/Swiss-Prot:P80858" /translation="MMPRTIIEKIWDQHIVKHGEGKPDLLYIDLHLIHEVTSPQAFEG LRQKGRKVRRPQNTFATMDHNIPTVNRFEIKDEVAKRQVTALERNCEEFGVRLADLHS VDQGIVHVVGPELGLTLPGKTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLSTQTLWQ QRPKTLEVRVDGTLQKGVTAKDVILAVIGKYGVKFGTGYVIEYTGEVFRNMTMDERMT VCNMSIEAGARAGLIAPDEVTFEYCKNRKYTPKGEEFDKAVEEWKALRTDPGAVYDKS IVLDGNKISPMVTWGINPGMVLPVDSEVPAPESFSAEDDKKEAIRAYEYMGLTPHQKI EDIKVEHVFIGSCTNSRMTDLRQAADMIKGKKVADSVRAIVVPGSQSVKLQAEKEGLD QIFLEAGFEWRESGCSMCLSMNNDVVPEGERCASTSNRNFEGRQGKGARTHLVSPAMA AMAAIHGHFVDVRKFYQEKTVV*" /label="leuC CDS" gene complement(2395966..2397384) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /label="leuC gene" promotor_-35 2397273..2397277 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2397292..2397296 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2397292 /Source="Nicolas_upshifts" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2397434..2398531) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /EC_number="1.1.1.85" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10095787, 15228537, 15916605, 17389690" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10095787, 15228537, 15916605, 17389690; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydrogenase" /protein_id="NP_390705.2" /db_xref="EnsemblGenomes-Gn:BSU28270" /db_xref="EnsemblGenomes-Tr:CAB14787" /db_xref="GOA:P05645" /db_xref="InterPro:IPR004429" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG10675" /db_xref="UniProtKB/Swiss-Prot:P05645" /translation="MKKRIALLPGDGIGPEVLESATDVLKSVAERFNHEFEFEYGLIG GAAIDEHHNPLPEETVAACKNADAILLGAVGGPKWDQNPSELRPEKGLLSIRKQLDLF ANLRPVKVFESLSDASPLKKEYIDNVDFVIVRELTGGLYFGQPSKRYVNTEGEQEAVD TLFYKRTEIERVIREGFKMAAARKGKVTSVDKANVLESSRLWREVAEDVAQEFPDVKL EHMLVDNAAMQLIYAPNQFDVVVTENMFGDILSDEASMLTGSLGMLPSASLSSSGLHL FEPVHGSAPDIAGKGMANPFAAILSAAMLLRTSFGLEEEAKAVEDAVNKVLASGKRTR DLARSEEFSSTQAITEEVKAAIMSENTISNV*" /label="leuB CDS" gene complement(2397434..2398531) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /label="leuB gene" CDS complement(2398552..2400108) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /EC_number="2.3.3.13" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 16330546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-isopropylmalate synthase" /protein_id="NP_390706.1" /db_xref="EnsemblGenomes-Gn:BSU28280" /db_xref="EnsemblGenomes-Tr:CAB14788" /db_xref="GOA:P94565" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR002034" /db_xref="InterPro:IPR005671" /db_xref="InterPro:IPR013709" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036230" /db_xref="SubtiList:BG11948" /db_xref="UniProtKB/Swiss-Prot:P94565" /translation="MRKINFFDTTLRDGEQSPGVNLNTQEKLAIAKQLERLGADIIEA GFPASSRGDFLAVQEIARTIKNCSVTGLARCVKGDIDAAWEALKDGAQPRIHVFIATS DIHLKHKLKMTREQVIERAVGMVKYAKERFPIVQWSAEDACRTELPFLAEIVEKVIDA GASVINLPDTVGYLAPAEYGNIFKYMKENVPNIHKAKLSAHCHDDLGMAVANSLAAIE NGADQIECAVNGIGERAGNAALEEIAVALHTRKDFYQVETGITLNEIKRTSDLVSKLT GMAVPRNKAVVGDNAFAHESGIHQDGFLKEKSTYEIISPELVGVTADALVLGKHSGRH AFKDRLTALGFQFDSEEINKFFTMFKELTEKKKEITDEDLVSLILEEKVTDRKIGYEF LSLQVHYGTSQVPTATLSLKNQENAQLIQEAATGAGSVEAIYNTLERCIDKDVELLDY RIQSNRKGEDAFAQVYVRVLVNGKESAGRGIAQDVLEASAKAYLNAVNRQLVFQSNMS GLKNHTAVGS*" /label="leuA CDS" gene complement(2398552..2400108) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /label="leuA gene" promotor_-35 2398948..2398951 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2398964..2401405 /Source="Nicolas_S_feature" /locus_tag="new_2892550_2894991" /HighExp="Lbstat, C30, T0.30H, M9-stat, T1.30H, H2O2, M0t90, T2.0H, Salt, BC" /AntisenseName="ilvC" /AntisenseCor="-0.51305153097242795" /AntisenseRegPval="-18.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1070" upshifts 2398964 /Source="Nicolas_upshifts" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2398966..2398985 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2400095..2401123) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /EC_number="1.1.1.86" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 25393291, 25849365; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid isomeroreductase (NADP-dependent)" /protein_id="NP_390707.1" /db_xref="EnsemblGenomes-Gn:BSU28290" /db_xref="EnsemblGenomes-Tr:CAB14789" /db_xref="GOA:P37253" /db_xref="InterPro:IPR000506" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013023" /db_xref="InterPro:IPR013116" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR014359" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10672" /db_xref="UniProtKB/Swiss-Prot:P37253" /translation="MVKVYYNGDIKENVLAGKTVAVIGYGSQGHAHALNLKESGVDVI VGVRQGKSFTQAQEDGHKVFSVKEAAAQAEIIMVLLPDEQQQKVYEAEIKDELTAGKS LVFAHGFNVHFHQIVPPADVDVFLVAPKGPGHLVRRTYEQGAGVPALFAIYQDVTGEA RDKALAYAKGIGGARAGVLETTFKEETETDLFGEQAVLCGGLSALVKAGFETLTEAGY QPELAYFECLHELKLIVDLMYEEGLAGMRYSISDTAQWGDFVSGPRVVDAKVKESMKE VLKDIQNGTFAKEWIVENQVNRPRFNAINASENEHQIEVVGRKLREMMPFVKQGKKKE AVVSVAQN*" /label="ilvC CDS" gene complement(2400095..2401123) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /label="ilvC gene" CDS complement(2401147..2401665) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (small subunit)" /protein_id="NP_390708.2" /db_xref="EnsemblGenomes-Gn:BSU28300" /db_xref="EnsemblGenomes-Tr:CAB14790" /db_xref="GOA:P37252" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004789" /db_xref="InterPro:IPR019455" /db_xref="SubtiList:BG10671" /db_xref="UniProtKB/Swiss-Prot:P37252" /translation="MKRIITLTVVNRSGVLNRITGLFTKRHYNIESITVGHTETAGVS RITFVVHVEGENDVEQLTKQLNKQIDVLKVTDITNQSIVQRELALIKVVSAPSTRTEI NGIIEPFRASVVDVSRDSIVVQVTGESNKIEALIELLKPYGIKEIARTGTTAFARGTQ QKASSNKTISIV*" /label="ilvH CDS" gene complement(2401147..2401665) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /label="ilvH gene" promotor_-35 2401386..2401389 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2401405..2401409 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2401407 /Source="Nicolas_upshifts" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2401662..2403386) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (large subunit)" /protein_id="NP_390709.1" /db_xref="EnsemblGenomes-Gn:BSU28310" /db_xref="EnsemblGenomes-Tr:CAB14791" /db_xref="GOA:P37251" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012846" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10670" /db_xref="UniProtKB/Swiss-Prot:P37251" /translation="MGTNVQVDSASAECTQTMSGALMLIESLKKEKVEMIFGYPGGAV LPIYDKLYNSGLVHILPRHEQGAIHAAEGYARVSGKPGVVIATSGPGATNLVTGLADA MIDSLPLVVFTGQVATSVIGSDAFQEADILGITMPVTKHSYQVRQPEDLPRIIKEAFH IATTGRPGPVLIDIPKDVATIEGEFSYDHEMNLPGYQPTTEPNYLQIRKLVEAVSSAK KPVILAGAGVLHGKASEELKNYAEQQQIPVAHTLLGLGGFPADHPLFLGMAGMHGTYT ANMALHECDLLISIGARFDDRVTGNLKHFARNAKIAHIDIDPAEIGKIMKTQIPVVGD SKIVLQELIKQDGKQSDSSEWKKQLAEWKEEYPLWYVDNEEEGFKPQKLIEYIHQFTK GEAIVATDVGQHQMWSAQFYPFQKADKWVTSGGLGTMGFGLPAAIGAQLAEKDATVVA VVGDGGFQMTLQELDVIRELNLPVKVVILNNACLGMVRQWQEIFYEERYSESKFASQP DFVKLSEAYGIKGIRISSEAEAKEKLEEALTSREPVVIDVRVASEEKVFPMVAPGKGL HEMVGVKP*" /label="ilvB CDS" gene complement(2401662..2403386) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /label="ilvB gene" S_feature complement(2403387..2403507) /Source="Nicolas_S_feature" /locus_tag="new_2896973_2897093_c" /HighExp="T-5.40H, T-4.40H, S2, MG 120, Glucon, GM-0.2, T-2.40H, GM-0.1, HiOs, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1071" misc_RNA complement(2403508..2403754) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /product="T-box controlling synthesis of branched chain amino acids" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboILV RNA" gene complement(2403508..2403754) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /label="tboILV gene" downshifts complement(2403551) /Source="Nicolas_upshifts" /id="D1446" /incds=0 /nref=18 /ntot=78 /MaxReadThrough="7.67475" /MaxDrop="4.2339" /score="5.33237345" /energy="-13.8" /TU="U2190,U2191" /idTUdmin="U2195" /TUdmin=2682 /isTUend="FALSE" /label="downshifts" S_feature complement(2403755..2403881) /Source="Nicolas_S_feature" /locus_tag="new_2897341_2897467_c" /HighExp="LoTm, HiOs, T-3.40H, BC, B60, Pyr, GM 15, T-5.40H, UNK1, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1072" promotor_-10 complement(2403863..2403882) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-10" upshifts complement(2403881) /Source="Nicolas_upshifts" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="upshifts" S_feature complement(2403883..2404013) /Source="Nicolas_S_feature" /locus_tag="new_2897469_2897599_c" /HighExp="Cold, S8, S0, S7, Mal, S6, G135, M9-stat, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1073" promotor_-35 complement(2403897..2403904) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-35" promotor_-10 complement(2404008..2404027) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2404017) /Source="Nicolas_upshifts" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="upshifts" promotor_-35 complement(2404041..2404044) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" promotor_-35 2404139..2404148 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2404162..2404181 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2404164 /Source="Nicolas_upshifts" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="upshifts" CDS 2404202..2404537 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_390710.1" /db_xref="EnsemblGenomes-Gn:BSU28320" /db_xref="EnsemblGenomes-Tr:CAB14792" /db_xref="SubtiList:BG12335" /db_xref="UniProtKB/Swiss-Prot:P94563" /translation="MNKSFADMQGFPAGFPSFPNFPQQYYPAVPPFYQQSQQPFGGYG YGQPFSQAYSPLTTPSGMYSSFPYASGFYGQQFSGAGFSGHGGSLSAPAIHAGGFSGA PGVHGGFRY*" /label="cotQ CDS" gene 2404202..2404537 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /label="cotQ gene" downshifts 2404531 /Source="Nicolas_upshifts" /id="D1447" /incds=0 /nref=14 /ntot=36 /MaxReadThrough="3.79194" /MaxDrop="6.48183" /score="11.836855" /energy="-13" /TU="U2192" /idTUdmin="U2193" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-35 2404618..2404625 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2404639..2404658 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2404641..2404705 /Source="Nicolas_S_feature" /locus_tag="new_2898227_2898291" /HighExp="S5, S6, S8, S7, B36, S4, S3, B60, BT, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.954, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1074" upshifts 2404641 /Source="Nicolas_upshifts" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="upshifts" CDS 2404706..2405161 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17555270, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative indole acetic acid N-acetyltransferase" /protein_id="NP_390711.1" /db_xref="EnsemblGenomes-Gn:BSU28330" /db_xref="EnsemblGenomes-Tr:CAB14793" /db_xref="GOA:P94562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YX0" /db_xref="SubtiList:BG12336" /db_xref="UniProtKB/Swiss-Prot:P94562" /translation="MHIKIDDLTGRQVVSLVNEHLHSMTLMSPPESIHALGLEKLRGP EITFWSAWEGDELAGCGALKELDTRHGEIKSMRTSASHLRKGVAKQVLQHIIEEAEKR GYERLSLETGSMASFEPARKLYESFGFQYCEPFADYGEDPNSVFMTKKL*" /label="ysnE CDS" gene 2404706..2405161 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /label="ysnE gene" promotor_-35 2405269..2405275 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2405289..2405307 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2405296 /Source="Nicolas_upshifts" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="upshifts" CDS 2405345..2406166 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 27464829; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative stress response protein" /protein_id="NP_390712.3" /db_xref="EnsemblGenomes-Gn:BSU28340" /db_xref="EnsemblGenomes-Tr:CAB14794" /db_xref="InterPro:IPR019060" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG12337" /db_xref="UniProtKB/Swiss-Prot:P94560" /translation="MKSIVGVYETPQETIAAIEGLLTKGYDSDDISVVTSRRDTDYLE SRTGTEVNQAIDAHQDESESFFDKLKDYFTMDDTATHSKALSDLDIKTDEIDKYQEDL DDGKLLVAVDTDADVIAPIDNGNALSGGFSSTNELDYTTKEEKTMPLREEQLKVDKED VQTGEVEIGKEVKTEKRDMDIPVRHDEIYVERRPVDENKTDAAPVNDSEEIRVPIVEE KLEVTKKPVVTDEVVVGKRTVEENEHISETVKKEEPRLNKEGKVDGLDDDPLNNK*" /label="ysnF CDS" gene 2405345..2406166 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /label="ysnF gene" downshifts 2406159 /Source="Nicolas_upshifts" /id="D1448" /incds=0 /nref=8 /ntot=77 /MaxReadThrough="2.49244" /MaxDrop="8.12771" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts 2406223 /Source="Nicolas_upshifts" /id="D1449" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="1.26489" /MaxDrop="4.30778" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin=43 /isTUend="FALSE" /label="downshifts" tRNA complement(2406230..2406303) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg (UCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Arg2 tRNA" gene complement(2406230..2406303) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /label="trnSL-Arg2 gene" downshifts complement(2406264) /Source="Nicolas_upshifts" /id="D1450" /incds=0 /nref=34 /ntot=243 /MaxReadThrough="1.54905" /MaxDrop="4.72186" /score="24.0242272" /energy="-13.3" /TU="U2195,U2196" /idTUdmin="U2195" /TUdmin="-31" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2406340..2406359) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2406343) /Source="Nicolas_upshifts" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2406373..2406380) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2406434..2406943) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /EC_number="3.1.4.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390713.2" /db_xref="EnsemblGenomes-Gn:BSU28350" /db_xref="EnsemblGenomes-Tr:CAB14795" /db_xref="GOA:P94559" /db_xref="InterPro:IPR000979" /db_xref="InterPro:IPR020935" /db_xref="InterPro:IPR024654" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12334" /db_xref="UniProtKB/Swiss-Prot:P94559" /translation="MNVLIISDSHGLEEELQTIAKRHEAEVDLMIHCGDSELETRHPA LEPYAVVKGNCDFAGDFKDELLLTAGSRKILVTHGHLHGIKQTLLNVYYRAEELGADV ICFGHSHIAGSEVLRGKLMINPGSIRLPRVRRTESYAILTLENDAATVRFYDQAGNEI EDLQNRVTL*" /label="ysnB CDS" gene complement(2406434..2406943) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /label="ysnB gene" downshifts complement(2406451) /Source="Nicolas_upshifts" /id="D1451" /incds=0 /nref=87 /ntot=225 /MaxReadThrough="4.15666" /MaxDrop="5.59323" /score="24.0242272" /energy="-13.3" /TU="U2196,U2197" /idTUdmin="U2197" /TUdmin="-130" /isTUend="FALSE" /label="downshifts" CDS complement(2406959..2407555) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /EC_number="3.6.1.66" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16322510, 17090528, 17976651, 18689515, 19943897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyinosine/deoxyxanthosine triphosphate pyrophosphatase, promiscuous (subunit A)" /protein_id="NP_390714.1" /db_xref="EnsemblGenomes-Gn:BSU28360" /db_xref="EnsemblGenomes-Tr:CAB14796" /db_xref="GOA:P94558" /db_xref="InterPro:IPR002637" /db_xref="InterPro:IPR020922" /db_xref="InterPro:IPR029001" /db_xref="SubtiList:BG12333" /db_xref="UniProtKB/Swiss-Prot:P94558" /translation="MIIMKEAIIATHNPGKVKEFKEILEPRGYDVKSLAEIGFTEEIE ETGHTFEENAIMKAEAVAKAVNKMVIADDSGLSIDNLGGRPGVYSARYAGEQKDDQAN IEKVLSELKGIEKEQRTARFRCALAVSIPGEETKTVEGHVEGYIAEEPRGEYGFGYDP IFIVKDKDKTMAELTSDEKNKISHRADALKKLSKLLEA*" /label="rdgB CDS" gene complement(2406959..2407555) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /label="rdgB gene" CDS complement(2407568..2408305) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /EC_number="2.7.7.56" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1624460, 19153445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624460, 19153445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease PH" /protein_id="NP_390715.1" /db_xref="EnsemblGenomes-Gn:BSU28370" /db_xref="EnsemblGenomes-Tr:CAB14797" /db_xref="GOA:P28619" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR002381" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR018336" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="PDB:1OYP" /db_xref="PDB:1OYR" /db_xref="PDB:1OYS" /db_xref="SubtiList:BG10357" /db_xref="UniProtKB/Swiss-Prot:P28619" /translation="MRHDGRQHDELRPITFDLDFISHPEGSVLITAGNTKVICNASVE DRVPPFLRGGGKGWITAEYSMLPRATNQRTIRESSKGKISGRTMEIQRLIGRALRAVV DLEKLGERTIWIDCDVIQADGGTRTASITGAFLAMAIAIGKLIKAGTIKTNPITDFLA AISVGIDKEQGILLDLNYEEDSSAEVDMNVIMTGSGRFVELQGTGEEATFSREDLNGL LGLAEKGIQELIDKQKEVLGDSLPELK*" /label="rph CDS" gene complement(2407568..2408305) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /label="rph gene" promotor_-10 complement(2408387..2408406) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2408403) /Source="Nicolas_upshifts" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2408416..2409516) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14662349, 27381174" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14662349, 27381174; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination (cortex hydrolysis) and sporulation (stage II, multiple polar septa) lytic enzyme" /protein_id="NP_390716.1" /db_xref="EnsemblGenomes-Gn:BSU28380" /db_xref="EnsemblGenomes-Tr:CAB14798" /db_xref="GOA:P39072" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10356" /db_xref="UniProtKB/Swiss-Prot:P39072" /translation="MLKKGPAVIGATCLTSALLLSGCGLFQSDKAAEEIDPPQDVTFV NDEAGANSNTTAAKKTESEKSDTAKADQASSTVMRELYLIDKNGYVVAQTLPLPKSES TAKQALEYLVQGGPVSEILPNGFRAVLPADTTVNVDIKKDGTAIADFSNEFKNYKKED EQKIVQSVTWTLTQFSSIDKVKLRINGHELKEMPVGGTPISDDLSRKDGINLETAGVN DLTATHPLTVYYLAENEDSEYYVPVTKRIDNSEKDDITAAINELAKGPSKVSGLLTDF SEDVKLVSKPKIKDGRVTLDFNQSIFGSADEKTKMISSEVLNSIVLTLTEQPDVKSVS VKVNGKSELVNEKGEKLTEPVSRPSQVNTGSF*" /label="gerM CDS" gene complement(2408416..2409516) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /label="gerM gene" promotor_-35 complement(2408421..2408426) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2408433) /Source="Nicolas_upshifts" /id="D1452" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="5.80816" /MaxDrop="4.3535" /score="41.5916163" /energy="-13" /TU="U2197" /idTUdmin="U2198" /TUdmin=1209 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2409539..2409557) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2409555) /Source="Nicolas_upshifts" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2409572..2409577) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2409631..2410449) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /EC_number="5.1.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15347750, 17610893, 17720142, 19309142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate racemase" /protein_id="NP_390717.2" /db_xref="EnsemblGenomes-Gn:BSU28390" /db_xref="EnsemblGenomes-Tr:CAB14799" /db_xref="GOA:P94556" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004391" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="PDB:1ZUW" /db_xref="SubtiList:BG11964" /db_xref="UniProtKB/Swiss-Prot:P94556" /translation="MLEQPIGVIDSGVGGLTVAKEIMRQLPKENIIYVGDTKRCPYGP RPEEEVLQYTWELTNYLLENHHIKMLVIACNTATAIALDDIQRSVGIPVVGVIQPGAR AAIKVTDNQHIGVIGTENTIKSNAYEEALLALNPDLKVENLACPLLVPFVESGKFLDK TADEIVKTSLYPLKDTSIDSLILGCTHYPILKEAIQRYMGEHVNIISSGDETAREVST ILSYKGLLNQSPIAPDHQFLTTGARDQFAKIADDWFGHEVGHVECISLQEPIKR*" /label="rcmE CDS" gene complement(2409631..2410449) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /label="rcmE gene" downshifts complement(2409643) /Source="Nicolas_upshifts" /id="D1453" /incds=0 /nref=230 /ntot=265 /MaxReadThrough="0.9265" /MaxDrop="6.72492" /score="41.5916163" /energy="-13" /TU="NA" /idTUdmin="U2198" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2410457..2410897) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26577401; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (mother cell's gene expression during sporulation)" /protein_id="NP_390718.1" /db_xref="EnsemblGenomes-Gn:BSU28400" /db_xref="EnsemblGenomes-Tr:CAB14800" /db_xref="GOA:P97247" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12332" /db_xref="UniProtKB/Swiss-Prot:P97247" /translation="MTSKPLEHVADIEKSLRHIAAIIKQKGREILNQYAITPPQFVGL QWLYELGDMTIGELSGKMYLACSTTTDLIDRMQKNELVERVKDPADRRVVRIHLLPEG ERIIQEVITKRQEYLRDMFESFTDEEIAIFEKSLMKLQHEMKRK*" /label="ysmB CDS" gene complement(2410457..2410897) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /label="ysmB gene" promotor_-10 complement(2410940..2410959) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2410949) /Source="Nicolas_upshifts" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2410951..2411093) /Source="Nicolas_S_feature" /locus_tag="new_2904537_2904679_c" /HighExp="BT, B36, S6, S8, S7, B60, Pyr, G/S, Lbtran, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.121047" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1075" promotor_-35 complement(2410975..2410979) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2411138) /Source="Nicolas_upshifts" /id="D1454" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="6.16749" /MaxDrop="4.6532" /score="20.9204638" /energy="-10.8" /TU="U2200,U2202" /idTUdmin="U2202" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" CDS complement(2411141..2411365) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transcriptional regulator required for the expression of late spore coat genes" /protein_id="NP_390719.2" /db_xref="EnsemblGenomes-Gn:BSU28410" /db_xref="EnsemblGenomes-Tr:CAB14801" /db_xref="GOA:P11470" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1FSE" /db_xref="SubtiList:BG10355" /db_xref="UniProtKB/Swiss-Prot:P11470" /translation="MKEKEFQSKPLLTKREREVFELLVQDKTTKEIASELFISEKTVR NHISNAMQKLGVKGRSQAVVELLRMGELEL*" /label="gerE CDS" gene complement(2411141..2411365) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /label="gerE gene" upshifts 2411414 /Source="Nicolas_upshifts" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2411416..2411434 /Source="Nicolas_upshift_promotors" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2411423..2411442) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2411443) /Source="Nicolas_upshifts" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2411456..2411465) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2411481..2411924) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390720.1" /db_xref="EnsemblGenomes-Gn:BSU28420" /db_xref="EnsemblGenomes-Tr:CAB14802" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10354" /db_xref="UniProtKB/Swiss-Prot:P11469" /translation="MKLPAYIDMPFQEWKTSFSFFNKVSVRFSETDMFGHMNNVTPFI YFEEVRISYFKKLNMMSENKQTMTVVASQQCDYLRQVMPYEELRIYVKTSAVGSSSLT LHYLGENLEGEPCFTGAVVMVQVSKESGKAVSWTDEEKETLLHTR*" /label="ysmA CDS" gene complement(2411481..2411924) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /label="ysmA gene" CDS complement(2411985..2412746) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 22720735, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 22720735, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (iron-sulfur protein)" /protein_id="NP_390721.1" /db_xref="EnsemblGenomes-Gn:BSU28430" /db_xref="EnsemblGenomes-Tr:CAB14803" /db_xref="GOA:P08066" /db_xref="InterPro:IPR004489" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR025192" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG10353" /db_xref="UniProtKB/Swiss-Prot:P08066" /translation="MSEQKTIRFIITRQDTADSTPYDEEFEIPYRPNLNVISALMEIR RNPVNVKGEKTTPVTWDMNCLEEVCGACSMVINGKPRQSCTALIDQLEQPIRLKPMKT FPVVRDLQVDRSRMFDSLKKVKAWIPIDGTYDLGPGPRMPEKRRQWAYELSKCMTCGV CLEACPNVNSKSKFMGPAPMSQVRLFNAHPTGAMNKSERLEALMDEGGLADCGNSQNC VQSCPKGIPLTTSIAALNRDTNLQAFRNFFGSDRV*" /label="sdhB CDS" gene complement(2411985..2412746) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /label="sdhB gene" downshifts complement(2411993) /Source="Nicolas_upshifts" /id="D1455" /incds=0 /nref=61 /ntot=257 /MaxReadThrough="5.46426" /MaxDrop="4.6864" /score="20.9204638" /energy="-10.8" /TU="U2202" /idTUdmin="U2205" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2412749..2414509) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 18535631, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 18535631, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (flavoprotein subunit)" /protein_id="NP_390722.2" /db_xref="EnsemblGenomes-Gn:BSU28440" /db_xref="EnsemblGenomes-Tr:CAB14804" /db_xref="GOA:P08065" /db_xref="InterPro:IPR003952" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR011280" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10352" /db_xref="UniProtKB/Swiss-Prot:P08065" /translation="MSQSSIIVVGGGLAGLMATIKAAESGMAVKLFSIVPVKRSHSVC AQGGINGAVNTKGEGDSPWEHFDDTVYGGDFLANQPPVKAMCEAAPSIIHLLDRMGVM FNRTPEGLLDFRRFGGTQHHRTAYAGATTGQQLLYALDEQVRRYEVAGLVTKYEGWEF LGAVLDDDRTCRGIVAQNLTNMQIESFRSDAVIMATGGPGIIFGKSTNSMINTGSAAS IVYQQGAYYANGEFIQIHPTAIPGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKY PAYGNLVPRDIATREIFDVCVNQKLGINGENMVYLDLSHKDPKELDIKLGGIIEIYEK FMGDDPRKLPMKIFPAVHYSMGGLWVDYDQMTNIPGLFAAGECDYSMHGGNRLGANSL LSAIYGGMVAGPNAVKYVNGLESSAEDMSSSLFDAHVKKEEEKWADIMSMDGTENAYV LHKELGEWMTANVTVVRHNDKLLKTDDKIQELMERFKKININDTTKWSNQGAMFTRQF SNMLQLARVITLGAYNRNESRGAHYKPDYPERNDDEWLKTTMAKHVSPYEAPEFEYQD VDVSLITPRKRDYSKKKVAK*" /label="sdhA CDS" gene complement(2412749..2414509) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /label="sdhA gene" CDS complement(2414543..2415151) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /EC_number="1.3.5.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (cytochrome b558 subunit)" /protein_id="NP_390723.1" /db_xref="EnsemblGenomes-Gn:BSU28450" /db_xref="EnsemblGenomes-Tr:CAB14805" /db_xref="GOA:P08064" /db_xref="InterPro:IPR000701" /db_xref="InterPro:IPR011138" /db_xref="InterPro:IPR016002" /db_xref="InterPro:IPR034804" /db_xref="SubtiList:BG10351" /db_xref="UniProtKB/Swiss-Prot:P08064" /translation="MSGNREFYFRRLHSLLGVIPVGIFLIQHLVVNQFAARGAEAFNS AAHFMDSLPFRYALEIFIIFLPLIYHAVYGVYIAFTAKNNAGQYSYMRNWLFVLQRVT GIITLIFVSWHVWETRIAAQMGAEVNFDMMANILSSPAMLGFYIVGVLSTIFHFSNGL WSFAVTWGITVTPRSQRISTYVTLIIFVALSYVGLKAIFAFV*" /label="sdhC CDS" gene complement(2414543..2415151) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /label="sdhC gene" promotor_-35 2414921..2414928 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2414941..2414960 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2414943 /Source="Nicolas_upshifts" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2415152..2415247) /Source="Nicolas_S_feature" /locus_tag="new_2908738_2908833_c" /HighExp="Lbtran, dia5, Mt0, T0.30H, T1.0H, M0t90, M40t90, T0.0H, Glucon, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.78844099999999995" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1076" promotor_-10 complement(2415237..2415256) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-10" upshifts complement(2415247) /Source="Nicolas_upshifts" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="upshifts" S_feature complement(2415249..2415870) /Source="Nicolas_S_feature" /locus_tag="new_2908835_2909456_c" /HighExp="MG 120, B36, UNK1, Fru, MG 150, BMM, Gly, Glucon, Glu, GM-0.1" /AntisenseName="yslB" /AntisenseCor="-0.44143968421748903" /AntisenseRegPval="-13.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1077" promotor_-35 complement(2415271..2415278) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-35" promotor_-35 2415386..2415390 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2415400..2415500 /Source="Nicolas_upshift_promotors" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2415407..2415426 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2415416 /Source="Nicolas_upshifts" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="upshifts" CDS 2415444..2415890 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390724.1" /db_xref="EnsemblGenomes-Gn:BSU28460" /db_xref="EnsemblGenomes-Tr:CAB14806" /db_xref="InterPro:IPR019642" /db_xref="InterPro:IPR024096" /db_xref="PDB:3NJC" /db_xref="SubtiList:BG11236" /db_xref="UniProtKB/Swiss-Prot:P42955" /translation="MKSKFEASIDNLKEIEMNAYAYELIREIVLPDMLGQDYSSMMYW AGKHLARKFPLESWEEFPAFFEEAGWGTLTNVSAKKQELEFELEGPIISNRLKHQKEP CFQLEAGFIAEQIQLMNDQIAESYEQVKKRADKVVLTVKWDMKDPV*" /label="yslB CDS" gene 2415444..2415890 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /label="yslB gene" upshifts 2415460 /Source="Nicolas_upshifts" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="upshifts" downshifts 2415878 /Source="Nicolas_upshifts" /id="D1456" /incds=0 /nref=217 /ntot=255 /MaxReadThrough="2.21897" /MaxDrop="6.5759" /score="4.74486914" /energy="-10.8" /TU="NA" /idTUdmin="U2203" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2415916) /Source="Nicolas_upshifts" /id="D1457" /incds=0 /nref=8 /ntot=160 /MaxReadThrough="5.89867" /MaxDrop="4.19639" /score="2.38159916" /energy="-10.8" /TU="U2205" /idTUdmin="U2206" /TUdmin=1270 /isTUend="FALSE" /label="downshifts" CDS complement(2415934..2417160) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2981221, 2981222, 14597663, 1980002, 8757727, 9851048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2981221, 2981222, 14597663, 1980002, 8757727, 9851048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II alpha subunit (aa 1->408)" /protein_id="NP_390725.1" /db_xref="EnsemblGenomes-Gn:BSU28470" /db_xref="EnsemblGenomes-Tr:CAB14807" /db_xref="GOA:P08495" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10350" /db_xref="UniProtKB/Swiss-Prot:P08495" /translation="MGLIVQKFGGTSVGSVEKIQNAANRAIAEKQKGHQVVVVVSAMG KSTDELVSLAKAISDQPSKREMDMLLATGEQVTISLLSMALQEKGYDAVSYTGWQAGI RTEAIHGNARITDIDTSVLADQLEKGKIVIVAGFQGMTEDCEITTLGRGGSDTTAVAL AAALKADKCDIYTDVPGVFTTDPRYVKSARKLEGISYDEMLELANLGAGVLHPRAVEF AKNYQVPLEVRSSTETEAGTLIEEESSMEQNLIVRGIAFEDQITRVTIYGLTSGLTTL STIFTTLAKRNINVDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIET ESKLAKVSIVGSGMVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAV ESLHDAFELSKHPSAV*" /label="lysCA CDS" CDS complement(2415934..2416425) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1980002, 2981221, 2981222, 8757727, 9851048, 14597663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1980002, 2981221, 2981222, 8757727, 9851048, 14597663; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II beta subunit (aa 246->408)" /protein_id="YP_009513994.1" /translation="MEQNLIVRGIAFEDQITRVTIYGLTSGLTTLSTIFTTLAKRNIN VDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIETESKLAKVSIVGSG MVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAVESLHDAFELSKHP SAV*" /label="lysCB CDS" gene complement(2415934..2417160) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /label="lysCA gene" gene complement(2415934..2416425) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /label="lysCB gene" downshifts complement(2417274) /Source="Nicolas_upshifts" /id="D1458" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="7.23315" /MaxDrop="4.15833" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=44 /isTUend="FALSE" /label="downshifts" misc_RNA complement(2417286..2417465) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:14523230, 14597663, 14627808, 21169337, 22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523230, 14597663, 14627808, 21169337, 22416067; Product type n: RNA" /label="kswC RNA" gene complement(2417286..2417465) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /label="kswC gene" downshifts complement(2417318) /Source="Nicolas_upshifts" /id="D1459" /incds=0 /nref=22 /ntot=132 /MaxReadThrough="7.09997" /MaxDrop="4.61976" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2417490..2417509) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-10" upshifts complement(2417497) /Source="Nicolas_upshifts" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="upshifts" promotor_-35 complement(2417522..2417529) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-35" CDS complement(2417530..2419302) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /EC_number="4.1.99.3" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8655545, 16267290, 16426634, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655545, 16267290, 16426634, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit C)" /protein_id="NP_390727.2" /db_xref="EnsemblGenomes-Gn:BSU28490" /db_xref="EnsemblGenomes-Tr:CAB14809" /db_xref="GOA:P14951" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR001162" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004791" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR035901" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10349" /db_xref="UniProtKB/Swiss-Prot:P14951" /translation="MNKQLKEKLALLPDQPGCYLMKDRQQTVIYVGKAKVLKNRVRSY FTGSHDAKTQRLVTEIEDFEYIVTSSNLEALILEMNLIKKHDPKYNVMLKDDKTYPFI KLTHERHPRLIVTRNVKKDKGRYFGPYPNVQAARETKKLLDRLYPLRKCSKLPDRVCL YYHLGQCLAPCVKDISEETNRELVESITRFLRGGYNEVKKELEEKMHEAAENLEFERA KELRDQIAHIESTMEKQKMTMNDLVDRDVFAYAYDKGWMCVQVFFIRQGKLIERDVSM FPLYQEADEEFLTFIGQFYSKNNHFLPKEILVPDSIDQSMIEQLLETNVHQPKKGPKK ELLMLAHKNAKIALKEKFSLIERDEERSIGAVQKLGEALNIYTPHRIEAFDNSNIQGT NPVSAMIVFIDGKPYKKEYRKYKIKTVTGPDDYGSMREVVRRRYTRVLRENLPLPDLI IIDGGKGQINAARDVIENELGLDIPIAGLAKDEKHRTSNLLIGDPLEVAYLERNSQEF YLLQRIQDEVHRFAISFHRQIRGKSAFQSVLDDIPGIGEKRKKMLLKHFGSVKKMKEA SLEDIKKAGVPAAAAQLLYDKLQK*" /label="uvrC CDS" gene complement(2417530..2419302) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /label="uvrC gene" promotor_-10 complement(2419329..2419348) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-10" upshifts complement(2419343) /Source="Nicolas_upshifts" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="upshifts" promotor_-35 complement(2419362..2419369) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-35" downshifts complement(2419432) /Source="Nicolas_upshifts" /id="D1460" /incds=0 /nref=237 /ntot=268 /MaxReadThrough="4.77689" /MaxDrop="6.41061" /score="23.4086154" /energy="-10.5" /TU="U2207,U2208" /idTUdmin="U2209" /TUdmin=373 /isTUend="FALSE" /label="downshifts" CDS complement(2419438..2419752) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268; Product type c: carrier" /codon_start=1 /transl_table=11 /product="thioredoxin" /protein_id="NP_390728.1" /db_xref="EnsemblGenomes-Gn:BSU28500" /db_xref="EnsemblGenomes-Tr:CAB14810" /db_xref="GOA:P14949" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:2GZY" /db_xref="PDB:2GZZ" /db_xref="PDB:2IPA" /db_xref="PDB:2VOC" /db_xref="SubtiList:BG10348" /db_xref="UniProtKB/Swiss-Prot:P14949" /translation="MAIVKATDQSFSAETSEGVVLADFWAPWCGPCKMIAPVLEELDQ EMGDKLKIVKIDVDENQETAGKYGVMSIPTLLVLKDGEVVETSVGFKPKEALQELVNK HL*" /label="trxA CDS" gene complement(2419438..2419752) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /label="trxA gene" promotor_-10 complement(2419778..2419797) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2419792) /Source="Nicolas_upshifts" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2419794..2420003) /Source="Nicolas_S_feature" /locus_tag="new_2913380_2913589_c" /HighExp="Etha, Salt, Gly, Sw, M9-stat, LPhT, BC, B60, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984399999999996" /TUshortSig="SigB, SigA" /TUshortPSig="0.991, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1078" promotor_-35 complement(2419813..2419815) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2419897..2420007) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="CDS C-terminal fragment" /db_xref="PSEUDO:SOX90589.1" /translation="MVKYMTVKRRCDLMLRTILMIIGAIVVIGAIIRFVF*" /label="CDS C-terminal fragment" gene complement(2419897..2420007) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /pseudo /label="gene" promotor_-10 complement(2419993..2420011) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-10" upshifts complement(2420003) /Source="Nicolas_upshifts" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="upshifts" promotor_-35 complement(2420026..2420032) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-35" CDS complement(2420075..2421562) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 17827291, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 17827291, 18757805; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exo-alpha-L-arabinofuranosidase" /protein_id="NP_390729.2" /db_xref="EnsemblGenomes-Gn:BSU28510" /db_xref="EnsemblGenomes-Tr:CAB14811" /db_xref="GOA:P94552" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11985" /db_xref="UniProtKB/Swiss-Prot:P94552" /translation="MSEHQAVIQTDIAKGTINKNIYGHFAEHLGRGIYEGIWVGTDSD IPNINGIRKDVLEALKQLHIPVLRWPGGCFADEYHWANGVGDRKTMLNTHWGGTIESN EFGTHEFMMLCELLECEPYICGNVGSGTVQEMSEWIEYMTFEEGTPMSDWRKQNGREE PWKLKYFGVGNENWGCGGNMHPEYYADLYRRFQTYVRNYSGNDIYKIAGGANVDDFNW TDVLMKKAAGLMDGLSLHYYTIPGDFWKGKGSATEFTEDEWFITMKKAKYIDELIQKH GTIMDRYDPEQRVGLIIDEWGTWFDPEPGTNPGFLYQQNTIRDALVAASHFHIFHQHC RRVQMANIAQTVNVLQAMILTEGERMLLTPTYHVFNMFKVHQDASLLATETMSADYEW NGETLPQISISASKQAEGDINITICNIDHQNKAEAEIELRGLHKAADHSGVILTAEKM NAHNTFDDPHHVKPESFRQYTLSKNKLKVKLPPMSVVLLTLRADS*" /label="abfB CDS" gene complement(2420075..2421562) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /label="abfB gene" S_feature complement(2421563..2421675) /Source="Nicolas_S_feature" /locus_tag="new_2915149_2915261_c" /HighExp="T0.30H, M40t90, M0t90, BC, M9-stat, T1.30H, T1.0H, T2.0H, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1079" promotor_-10 complement(2421656..2421675) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-10" upshifts complement(2421675) /Source="Nicolas_upshifts" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="upshifts" promotor_-35 complement(2421690..2421697) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-35" CDS complement(2421779..2422756) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 20059546, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 20059546, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (alpha subunit)" /protein_id="NP_390730.1" /db_xref="EnsemblGenomes-Gn:BSU28520" /db_xref="EnsemblGenomes-Tr:CAB14812" /db_xref="GOA:P94551" /db_xref="InterPro:IPR001308" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR014731" /db_xref="InterPro:IPR018206" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR033947" /db_xref="SubtiList:BG11934" /db_xref="UniProtKB/Swiss-Prot:P94551" /translation="MGKKVIVLGEIRDGELRNVTFEAIAAGRTISGDGEVIGVLIGEN VQSIAQELIHYGADKVLTAEDPKLKTYTADGYSQVMRGVIEQENPDSVIFGHTAMGKD LSPKLAARLQTGLISDAIDVSVTGGNVVFTRPIYSGKAFERVISTDPMIFATIRPNNI QASEKDTSRSGSIESIDVSLTDLRTVIQEVVKKTADGVDLSEAKIIVAGGRGVKSKEG FQPLQELAEVLGAAVGASRGACDADYCDYALQIGQTGKVVTPDLYIACGISGAIQHLA GMSNSKVIVAINKDPEADIFKIADYGIVGDLFEVVPLLTEEFKQLNIHS*" /label="etfA CDS" gene complement(2421779..2422756) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /label="etfA gene" downshifts complement(2421787) /Source="Nicolas_upshifts" /id="D1461" /incds=0 /nref=58 /ntot=179 /MaxReadThrough="2.43782" /MaxDrop="7.95053" /score="30.2462458" /energy="-13.5" /TU="NA" /idTUdmin="U2210" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2422792..2423565) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10026281, 17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10026281, 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (beta subunit)" /protein_id="NP_390731.1" /db_xref="EnsemblGenomes-Gn:BSU28530" /db_xref="EnsemblGenomes-Tr:CAB14813" /db_xref="GOA:P94550" /db_xref="InterPro:IPR000049" /db_xref="InterPro:IPR012255" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR033948" /db_xref="SubtiList:BG11935" /db_xref="UniProtKB/Swiss-Prot:P94550" /translation="MNLFVLMKRTFDTEEKIVIETGKIQDDGAEWIINPYDEYAIEEA IQLKEKHGGTITAVTVGGEEAEKELRTALAMGCDQAVLINIEDDLDEPDQYSISQVLY HYMKDQEFDLILGGNVAIDGGSGQVAPRLAELLDIPCITTITKLEINGTDAEAERDVE GDVEKIKTTLPLLVTAQQGLNEPRYPSLPGIMKAKKKPLEELELDDLDLDEEDAEPKL KTIERFLPPKKEAGKLLQGEPAEQAKELVSLLRSEAKVI*" /label="etfB CDS" gene complement(2422792..2423565) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /label="etfB gene" CDS complement(2423580..2424356) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-CoA hydratase" /protein_id="NP_390732.1" /db_xref="EnsemblGenomes-Gn:BSU28540" /db_xref="EnsemblGenomes-Tr:CAB14814" /db_xref="GOA:P94549" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12331" /db_xref="UniProtKB/Swiss-Prot:P94549" /translation="MNAISLAVDQFVAVLTIHNPPANALSSRILEELSSCLDQCETDA GVRSIIIHGEGRFFSAGADIKEFTSLKGNEDSSLLAERGQQLMERIESFPKPIIAAIH GAALGGGLELAMACHIRIAAEDAKLGLPELNLGIIPGFAGTQRLPRYVGTAKALELIG SGEPISGKEALDLGLVSIGAKDEAEVIEKAKALAAKFAEKSPQTLASLLELLYSNKVY SYEGSLKLEAKRFGEAFESEDAKEGIQAFLEKRKPQFKGE*" /label="fadB CDS" gene complement(2423580..2424356) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /label="fadB gene" downshifts 2423645 /Source="Nicolas_upshifts" /id="D1462" /incds=1 /nref=1 /ntot=21 /MaxReadThrough="0.92259" /MaxDrop="4.42725" /score="-8.29305955" /energy="-5.1" /TU="NA" /idTUdmin="U2203" /TUdmin=7767 /isTUend="FALSE" /label="downshifts" CDS complement(2424371..2424955) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17189250, 18941141, 21398533, 24356978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 18941141, 21398533, 24356978; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of fatty acids degradation [FadR-long-chain (C14-C20) acyl-CoAs]" /protein_id="NP_390733.1" /db_xref="EnsemblGenomes-Gn:BSU28550" /db_xref="EnsemblGenomes-Tr:CAB14815" /db_xref="GOA:P94548" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013570" /db_xref="InterPro:IPR036271" /db_xref="PDB:1VI0" /db_xref="PDB:3WHB" /db_xref="PDB:3WHC" /db_xref="SubtiList:BG12330" /db_xref="UniProtKB/Swiss-Prot:P94548" /translation="MKQKRPKYMQIIDAAVEVIAENGYHQSQVSKIAKQAGVADGTIY LYFKNKEDILISLFKEKMGQFIERMEEDIKEKATAKEKLALVISKHFSLLAGDHNLAI VTQLELRQSNLELRQKINEILKGYLNILDGILTEGIQSGEIKEGLDVRLARQMIFGTI DETVTTWVMNDQKYDLVALSNSVLELLVSGIHNK*" /label="fadR CDS" gene complement(2424371..2424955) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /label="fadR gene" promotor_-10 complement(2424997..2425016) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2424997) /Source="Nicolas_upshifts" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2425029..2425036) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2425060..2426742) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17085570, 17189250, 21398533, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17085570, 17189250, 21398533, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long chain acyl-CoA ligase (degradative)" /protein_id="NP_390734.1" /db_xref="EnsemblGenomes-Gn:BSU28560" /db_xref="EnsemblGenomes-Tr:CAB14816" /db_xref="GOA:P94547" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG11946" /db_xref="UniProtKB/Swiss-Prot:P94547" /translation="MQSQKPWLAEYPNDIPHELPLPNKTLQSILTDSAARFPDKTAIS FYGKKLTFHDILTDALKLAAFLQCNGLQKGDRVAVMLPNCPQTVISYYGVLFAGGIVV QTNPLYTEHELEYQLRDAQVSVIITLDLLFPKAIKMKTLSIVDQILITSVKDYLPFPK NILYPLTQKQKVHIDFDKTANIHTFASCMKQEKTELLTIPKIDPEHDIAVLQYTGGTT GAPKGVMLTHQNILANTEMCAAWMYDVKEGAEKVLGIVPFFHVYGLTAVMNYSIKLGF EMILLPKFDPLETLKIIDKHKPTLFPGAPTIYIGLLHHPELQHYDLSSIKSCLSGSAA LPVEVKQKFEKVTGGKLVEGYGLSEASPVTHANFIWGKNKPGSIGCPWPSTDAAIYSE ETGELAAPYEHGEIIVKGPQVMKGYWNKPEETAAVLRDGWLFTGDMGYMDEEGFFYIA DRKKDIIIAGGYNIYPREVEEALYEHEAIQEIVVAGVPDSYRGETVKAFVVLKKGAKA DTEELDAFARSRLAPYKVPKAYEFRKELPKTAVGKILRRRLLEEETENHHIK*" /label="lcfA CDS" gene complement(2425060..2426742) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /label="lcfA gene" misc_feature complement(2426771..2426790) /Source="Nicolas_upshift_promotors" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2426779) /Source="Nicolas_upshifts" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2426867) /Source="Nicolas_upshifts" /id="D1463" /incds=0 /nref=8 /ntot=101 /MaxReadThrough="2.17789" /MaxDrop="3.3655" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2426931..2427335) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390735.1" /db_xref="EnsemblGenomes-Gn:BSU28570" /db_xref="EnsemblGenomes-Tr:CAB14817" /db_xref="GOA:P94546" /db_xref="InterPro:IPR007140" /db_xref="SubtiList:BG12329" /db_xref="UniProtKB/Swiss-Prot:P94546" /translation="MSDFWENELVEIAAYYSVAVLCLVLFLTVFELVTAYKNWEEIQK GNLAVAMATGGKILGIANVFQHSISQHNSLLQMIGWGVYGFVMLLISYFIFEFLTPRF KIDQEIENDNRAVGFISFVISVGLSFVVAAGI*" /label="yshE CDS" gene complement(2426931..2427335) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /label="yshE gene" downshifts complement(2426933) /Source="Nicolas_upshifts" /id="D1464" /incds=0 /nref=1 /ntot=75 /MaxReadThrough="3.74343" /MaxDrop="2.92029" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2427350..2429707) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11254128, 12719520, 22333191, 27799325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254128, 12719520, 22333191, 27799325; Product type f: factor" /codon_start=1 /transl_table=11 /product="homologous recombination factor" /protein_id="NP_390736.1" /db_xref="EnsemblGenomes-Gn:BSU28580" /db_xref="EnsemblGenomes-Tr:CAB14818" /db_xref="GOA:P94545" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR002625" /db_xref="InterPro:IPR005747" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036063" /db_xref="InterPro:IPR036187" /db_xref="SubtiList:BG12328" /db_xref="UniProtKB/Swiss-Prot:P94545" /translation="MQQKVLSALEFHKVKEQVIGHAASSLGKEMLLELKPSASIDEIK KQLDEVDEASDIIRLRGQAPFGGLVDIRGALRRAEIGSVLSPSEFTEISGLLYAVKQM KHFITQMAEDGVDIPLIHQHAEQLITLSDLERDINSCIDDHGEVLDHASETLRGIRTQ LRTLESRVRDRLESMLRSSSASKMLSDTIVTIRNDRFVIPVKQEYRSSYGGIVHDTSS SGATLFIEPQAIVDMNNSLQQAKVKEKQEIERILRVLTEKTAEYTEELFLDLQVLQTL DFIFAKARYAKAVKATKPIMNDTGFIRLKKARHPLLPPDQVVANDIELGRDFSTIVIT GPNTGGKTVTLKTLGLLTLMAQSGLHIPADEGSEAAVFEHVFADIGDEQSIEQSLSTF SSHMVNIVGILEQVNENSLVLFDELGAGTDPQEGAALAMSILDDVHRTNARVLATTHY PELKAYGYNREGVMNASVEFDIETLSPTYKLLIGVPGRSNAFEISKRLGLPDHIIGQA KSEMTAEHNEVDTMIASLEQSKKRAEEELSETESIRKEAEKLHKELQQQIIELNSKKD KMLEEAEQQAAEKVKAAMKEAEDIIHELRTIKEEHKSFKDHELINAKKRLEGAMPAFE KSKKPEKPKTQKRDFKPGDEVKVLTFGQKGTLLEKTGGNEWNVQIGILKMKVKEKDLE FIKSAPEPKKEKMITAVKGKDYHVSLELDLRGERYENALSRVEKYLDDAVLAGYPRVS IIHGKGTGALRKGVQDLLKNHRSVKSSRFGEAGEGGSGVTVVELK*" /label="mutSB CDS" gene complement(2427350..2429707) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /label="mutSB gene" CDS complement(2429728..2431440) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /EC_number="2.7.7.7" /EC_number="3.1.11.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:18776221, 18938175, 28254425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18776221, 18938175, 28254425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase/3'-5' exonuclease X" /protein_id="NP_390737.1" /db_xref="EnsemblGenomes-Gn:BSU28590" /db_xref="EnsemblGenomes-Tr:CAB14819" /db_xref="GOA:P94544" /db_xref="InterPro:IPR002054" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010996" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR022311" /db_xref="InterPro:IPR027421" /db_xref="InterPro:IPR029398" /db_xref="InterPro:IPR037160" /db_xref="SubtiList:BG12327" /db_xref="UniProtKB/Swiss-Prot:P94544" /translation="MHKKDIIRLLETIAVYMELKGDNPFKVSAFRKAAAALEQDDRSL SEMDDMMSLSGIGKGTYSVIKEYIDEGKSSTLESLQKEVPEGLVPLLKLPGLGGKKIA KLYKELGVHDAESLKEACEQQKVQGLAGFGKKSEEKILQALGEAGKQPERFPIGYALR IAREIEEHLSQFTHIIKFSRAGSLRRARETVKDLDYIIATDHPAEVREQLLELPNIKS VIASGDTKVSVILSFEYETSVDFRLVTEEQFPTTLHHFTGSKDHNIKMRQIAKERGER ISEYGVETVETGEIKTFPSEREFYAHFGLPLIPPEIRESGQEVETYSDSIELIELGQI KGDLHMHSTWSDGAFSIREMAEACIKKGYQYMAITDHSQYLKVANGLTAERLKQQAKE IDALNAEFENFRILKGVEMDILPDGTLDYDDDVLAEMDIVIASIHSSFNQPEHVIMKR LETALTNKHVDIIAHPTGRLIGRRAGYEIDIDQLIELARKTNTALELNANPARLDLRT EHLMKANEQGVTLVINTDAHNIEMLDDMKTGVTAARKGWTETKNVLNARSLKDVEAFL KRND*" /label="polX CDS" gene complement(2429728..2431440) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /label="polX gene" S_feature complement(2431441..2431513) /Source="Nicolas_S_feature" /locus_tag="new_2925027_2925099_c" /HighExp="Cold, LPhT, LBGstat, H2O2, dia15, G180, G135, Sw, G150, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1080" CDS complement(2431514..2432047) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390738.1" /db_xref="EnsemblGenomes-Gn:BSU28600" /db_xref="EnsemblGenomes-Tr:CAB14820" /db_xref="GOA:P94543" /db_xref="InterPro:IPR003825" /db_xref="SubtiList:BG12326" /db_xref="UniProtKB/Swiss-Prot:P94543" /translation="MLDIIILILLLMGTLLGLKRGFILQFIRLTSFILSIAFAALFYK NVAPHLHWIPAPDFSAGQPALSFFTGNLEAAYYNAIAFIVLFIIAKILLRIIGSFLSI VAGIPVIKQINQMLGAVLGFLEVYLFTFVLLYVASVLPVDALQQMMGQSSLANVIINH TPYLSGLLQELWTQYGA*" /label="yshB CDS" gene complement(2431514..2432047) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /label="yshB gene" CDS complement(2432054..2432311) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /experiment="publication(s) with functional evidences, PMID:15317782, 16796675, 18588879, 20711458, 24097947, 26258635" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317782, 16796675, 18588879, 20711458, 24097947, 26258635; Product type r : regulator" /codon_start=1 /transl_table=11 /product="regulator of cell division" /protein_id="NP_390739.1" /db_xref="EnsemblGenomes-Gn:BSU28610" /db_xref="EnsemblGenomes-Tr:CAB14821" /db_xref="GOA:P94542" /db_xref="InterPro:IPR007838" /db_xref="InterPro:IPR023688" /db_xref="InterPro:IPR036192" /db_xref="SubtiList:BG12325" /db_xref="UniProtKB/Swiss-Prot:P94542" /translation="MSDGKKTKTTVDIYGQHFTIVGEESRAHMRYVAGIVDDKMREIN EKNPYLDINKLAVLTAVNVVHDYVKLQEKCEKLERQLKEKD*" /label="zapA CDS" gene complement(2432054..2432311) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /label="zapA gene" promotor_-10 complement(2432338..2432357) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2432354) /Source="Nicolas_upshifts" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2432369..2432376) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2432394..2432413 /Source="Nicolas_upshift_promotors" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2432401 /Source="Nicolas_upshifts" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="upshifts" CDS 2432445..2433386 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /EC_number="3.1.26.4" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9888800, 10094689, 12794188, 23882084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888800, 10094689, 12794188, 23882084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HIII" /protein_id="NP_390740.1" /db_xref="EnsemblGenomes-Gn:BSU28620" /db_xref="EnsemblGenomes-Tr:CAB14822" /db_xref="GOA:P94541" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR004641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR024568" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12324" /db_xref="UniProtKB/Swiss-Prot:P94541" /translation="MSHSVIKVSLSAIDQMKMTYSGSLTASVPQGAVFQAKPPGCTIT AYQSGKVLFQGKNAAAESARWGTAEPQEKKKTAKKPADPRYAPPADIAGMSVIGSDEV GTGDYFGPMTVVCAYVDKTMLPLMKELGVKDSKDLKDPQIIEIARNLIKTIPYSLLVL KNEKYNSMQEKGMSQGKMKALLHNQAITHLLRKLDGVKPEAILIDQFAEPGVYFNHLK GRDIVKERTYFSTKAEGIHLAVAAASIIARYSFLMEMDKLSRAAGMTLPKGAGPHVDE AAAKLILKKGASALRTFTKLHFANTQKAQRLADKKRS*" /label="rnhC CDS" gene 2432445..2433386 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /label="rnhC gene" promotor_-10 complement(2433118..2433137) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2433133) /Source="Nicolas_upshifts" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2433151..2433158) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2433369 /Source="Nicolas_upshifts" /id="D1465" /incds=0 /nref=150 /ntot=232 /MaxReadThrough="1.71535" /MaxDrop="5.25365" /score="25.6336933" /energy="-13.7" /TU="NA" /idTUdmin="U2213" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2433401) /Source="Nicolas_upshifts" /id="D1466" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.4685" /MaxDrop="5.29665" /score="-4.45611985" /energy="-14.9" /TU="NA" /idTUdmin="U2216" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(2433422..2435836) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (beta subunit)" /protein_id="NP_390741.1" /db_xref="EnsemblGenomes-Gn:BSU28630" /db_xref="EnsemblGenomes-Tr:CAB14823" /db_xref="GOA:P17922" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004532" /db_xref="InterPro:IPR005121" /db_xref="InterPro:IPR005146" /db_xref="InterPro:IPR005147" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020825" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR036690" /db_xref="SubtiList:BG10875" /db_xref="UniProtKB/Swiss-Prot:P17922" /translation="MFVSYKWLEDYVDLKGMDPAVLAEKITRAGIEVEGIEYKGEGIK GVVIGHVLEREQHPNADKLNKCLVDIGAEAPVQIICGAPNVDKGQKVAVATVGAVLPG NFKIKKAKLRGEESNGMICSLQELGIESKLVAKEYAEGIFVFPNDAETGSDALAALQL DDAILELGLTPNRADAMNMLGVAYEVAAILDTEVKLPQTDYPAASEQASDYISVKIED QEANPLYTAKIIKNVTIAPSPLWMQTKLMNAGIRPHNNVVDITNFVLLEYGQPLHAFD YDRFGSKEVVVRKAAENEMIVTLDDQERKLSADHLVITNGTKAQAVAGVMGGAESEVQ EDTKTILLEAAYFNGQKVRKASKDLGLRSESSVRFEKGIDPARVRLAAERAAQLIHLY AGGEVLAGTVEEDHLTIEANNIHVSADKVSSVLGLTISKEELISIYKRLGFTVGEADD LLVVTVPSRRGDITIEEDLIEEAARLYGYDNIPSTLPETAGTTGGLTPYQAKRRKVRR FLEGAGLSQAITYSLTNEKKATAFAIEKSLNTVLALPMSEERSILRHSLVPNLLDSVS YNLARQTDSVALYEVGSVFLTKEEDTKPVETERVAGAVTGLWRKQLWQGEKKPVDFFV VKGIVEGLLDKLNVLDSIEFVQSERKQLHPGRTANILLNGSLIGFIGQVHPSLEKELD IKETYVFELDLHALLAAETAPLVYTAIPKYPSVTRDIALVTDKTVTSGQLESVIKEAG GKLLKEVTVFDVYEGEHMEEGKKSVAFSLQYVNPEQTLTEEEVTKAHSKVLKALEDTY QAVLRG*" /label="pheT CDS" gene complement(2433422..2435836) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /label="pheT gene" downshifts complement(2433445) /Source="Nicolas_upshifts" /id="D1467" /incds=0 /nref=214 /ntot=255 /MaxReadThrough="3.98669" /MaxDrop="7.11892" /score="32.4736491" /energy="-14.7" /TU="NA" /idTUdmin="U2216" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2435852..2436886) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390742.1" /db_xref="EnsemblGenomes-Gn:BSU28640" /db_xref="EnsemblGenomes-Tr:CAB14824" /db_xref="GOA:P17921" /db_xref="InterPro:IPR002319" /db_xref="InterPro:IPR004188" /db_xref="InterPro:IPR004529" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR022911" /db_xref="SubtiList:BG10874" /db_xref="UniProtKB/Swiss-Prot:P17921" /translation="MEEKLKQLEQEALEQVEAASSLKVVNDIRVQYLGKKGPITEVLR GMGKLSAEERPKMGALANEVRERIANAIADKNEKLEEEEMKQKLAGQTIDVTLPGNPV AVGGRHPLTVVIEEIEDLFIGMGYTVEEGPEVETDYYNFESLNLPKEHPARDMQDSFY ITEETLMRTQTSPVQTRTMEKHEGKGPVKIICPGKVYRRDNDDATHSHQFMQIEGLVV DKNISMSDLKGTLELVAKKMFGQDREIRLRPSFFPFTEPSVEVDVTCFKCGGNGCSVC KGTGWIEILGAGMVHPNVLKMAGFDPKEYQGFAFGMGVERIAMLKYGIDDIRHFYTND VRFISQFKQA*" /label="pheS CDS" gene complement(2435852..2436886) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /label="pheS gene" S_feature complement(2436887..2437207) /Source="Nicolas_S_feature" /locus_tag="new_2930473_2930793_c" /HighExp="HPh, Cold, GM 15, GM 10, Sw, C30, G150, MG-0.2, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1081" CDS 2436968..2437174 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513995.1" /translation="MWPRYHPYFRQTDAVVSFIDITESDSGSPLRAVYAVPATTQEVK PISGCVKNALSQRHFLPGKQLIRN*" /label="hypothetical protein CDS" gene 2436968..2437174 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /label="gene" S_feature 2437197..2437461 /Source="Nicolas_S_feature" /locus_tag="new_2930783_2931047" /HighExp="S8, S7, S6, BT, C30, B36, S5, Pyr, C90, Glucon" /AntisenseName="ysgA" /AntisenseCor="-0.23049778674462801" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.519" /TUlongSig="NA" /TUlongPSig="NA" /label="S1082" upshifts 2437197 /Source="Nicolas_upshifts" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2437202..2437221) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2437204..2437218 /Source="Nicolas_upshift_promotors" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2437207) /Source="Nicolas_upshifts" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2437236..2437239) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2437241..2437987) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 24809820, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal RNA methylase" /protein_id="NP_390743.1" /db_xref="EnsemblGenomes-Gn:BSU28650" /db_xref="EnsemblGenomes-Tr:CAB14825" /db_xref="GOA:P94538" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG12323" /db_xref="UniProtKB/Swiss-Prot:P94538" /translation="MKQIESAKNQKVKDWKKLHTKKERTKTNTFLIEGEHLVEEALKS PGIVKEILVKDETRIPSDLETGIQCYMLSEDAFSAVTETETPQQIAAVCHMPEEKLAT ARKVLLIDAVQDPGNLGTMIRTADAAGLDAVVLGDGTADAFNGKTLRSAQGSHFHIPV VRRNLPSYVDELKAEGVKVYGTALQNGAPYQEIPQSESFALIVGNEGAGVDAALLEKT DLNLYVPLYGQAESLNVAVAAAILVYHLRG*" /label="rlmBB CDS" gene complement(2437241..2437987) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /label="rlmBB gene" promotor_-10 complement(2438014..2438033) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-10" promotor_-35 2438020..2438026 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2438027) /Source="Nicolas_upshifts" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="upshifts" promotor_-10 2438040..2438051 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2438047..2438053) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-35" upshifts 2438054 /Source="Nicolas_upshifts" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="upshifts" CDS 2438106..2438321 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8171126, 10806362, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8171126, 10806362, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_390744.1" /db_xref="EnsemblGenomes-Gn:BSU28660" /db_xref="EnsemblGenomes-Tr:CAB14826" /db_xref="GOA:P94537" /db_xref="InterPro:IPR017525" /db_xref="SubtiList:BG12318" /db_xref="UniProtKB/Swiss-Prot:P94537" /translation="MDLNLRHAVIANVTGNNQEQLEHTIVDAIQSGEEKMLPGLGVLF EVIWQHASESEKNEMLKTLEGGLKPAE*" /label="sspI CDS" gene 2438106..2438321 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /label="sspI gene" S_feature complement(2438303..2439715) /Source="Nicolas_S_feature" /locus_tag="new_2931889_2933301_c" /HighExp="S6, S8, S7, BT, S5, C30, B36, S4, B60, C90" /AntisenseName="ysfB" /AntisenseCor="0.46970634471519201" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1083" promotor_-35 2438332..2438339 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2438355..2438374 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2438363 /Source="Nicolas_upshifts" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="upshifts" CDS 2438390..2439496 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (glycolate degradation operon)" /protein_id="NP_390745.2" /db_xref="EnsemblGenomes-Gn:BSU28670" /db_xref="EnsemblGenomes-Tr:CAB14827" /db_xref="InterPro:IPR008599" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12319" /db_xref="UniProtKB/Swiss-Prot:P94536" /translation="MFLQPLLAKKIIAEVKKMYEREVIIVNTDGLIMAGTNDERVGQF HEGALICAKERRSVIITKEDETRLKGVKAGINLPVFFDHDVIAVFGLTGEPAEIQPFG ELLRKMTELFIKESRHLEQSQWRERMLESFMIDWLQLKEWSPSFLEKAQLLGVDLSSR RQMILIQGYEWSPHDIEQMARSWKSSYPADLFIRWGNERILINHEVPQHEQRDRLLRK ILHICSFANTASSQYTAAGAGRAVASSSLTDSYEQAEKALAVSLKRKTPIFEEDLKLD MCLTEISPGTRNEFPQRVLGKALEHQELMNTIRTFFHHDLSLKQTAEDMHIHINTLRY RLAKAEQLTGLRFDRTEDVVTMYVALYFLDQDTK*" /label="ysfB CDS" gene 2438390..2439496 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /label="ysfB gene" promotor_-35 2439532..2439535 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2439551..2439570 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2439555 /Source="Nicolas_upshifts" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="upshifts" CDS 2439599..2441011 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase subunit" /protein_id="NP_390746.1" /db_xref="EnsemblGenomes-Gn:BSU28680" /db_xref="EnsemblGenomes-Tr:CAB14828" /db_xref="GOA:P94535" /db_xref="InterPro:IPR004113" /db_xref="InterPro:IPR004490" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR016171" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12320" /db_xref="UniProtKB/Swiss-Prot:P94535" /translation="MITKDVKEQLIQVSGPENFDDSNAGRLVYSYDATPQYQSMPDAV IAPRNTDEISRILTICSEHRVPIVPRGSGTNLCGGTCPTEGGLVLLFKHMNQILEIDE ENLTATVQPGVITLDMIRAVESKGLFYPPDPSSMKISTIGGNINENSGGLRGLKYGVT RDYVIGLEVVLANGDIIRTGGKLAKDVAGYDLTRLFVGSEGTLGIVTEAIVKLVPKPE TKKTLLALYENIDAAAQTVSDIIAAKIIPATLEFLDQPTLLVIEDYAKIGLPTSAKAV LLIEQDGPFETVERDMEKIEAICKKGDAVSVQTAQTEEEAFALTEARRSALSALARLK PTTILEDATVPRSEIANMVKAINDIAAKYDISICTFGHAGDGNLHPTCTTDIRNKDEM ERVEQAFAEIFEKAIELGGTITGEHGVGEMKAPYLEMKLKKEGIDAMKALKAAFDPRN ILNPGKMFAKDARKRVVAER*" /label="glcD CDS" gene 2439599..2441011 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /label="glcD gene" promotor_-10 complement(2439701..2439720) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2439715) /Source="Nicolas_upshifts" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2439733..2439742) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2441008..2442342 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase (iron-sulfur subunit)" /protein_id="NP_390747.1" /db_xref="EnsemblGenomes-Gn:BSU28690" /db_xref="EnsemblGenomes-Tr:CAB14829" /db_xref="GOA:P94534" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012257" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="SubtiList:BG12321" /db_xref="UniProtKB/Swiss-Prot:P94534" /translation="MTTEKEMKQIQNEFKERMDEGELLNCMRCGFCLPSCPTYIESGF QETHSPRGRIALMKAVADGMIEPDEDVERSLSLCLGCRACEPVCPSGVKYGQLLEEAR DIIHQNKKHSLGERVMRKTAFHELFPHQNRMRSAVSLIGLYQRSGLQTAVRKSGMLRV LPEHLRTMEAVLPDVPKSKDMKHRPRFLPSIGPMKKRVAFFSGCLMDTMFLPTNNATL KLLQLAGCDIVIPPEQACCGALHGHSGEKNTGKELAKQNIAAFEALDVDAVITNAGGC GAFLTEYDHLLKDDPEWSERAAAFVQKLKDFSSVLVELDFHQMDLALETPQVVTYQDS CHLRNVMHTSLEPRQLLKSIKGAEFKEMEKADSCCGSAGIYNIVEVEMSMKILDSKMA AVKATEAILIVTANPGCLLQMKLGIEREGLSGKVRAVHLADLLLEAAGHKTS*" /label="glcF CDS" gene 2441008..2442342 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /label="glcF gene" Polymorphism join(2442041,2442043) /Source="geneious" /ID="SNP_BsDelta6_2935628_2935628" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=1035 /Change="C -> T" /Codon_Change="CTC -> CTT" /Coverage=142 /locus_tag="BSU_28690" /Protein_Effect="None" /Reference_Frequency="1.4%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=140 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" downshifts 2442340 /Source="Nicolas_upshifts" /id="D1468" /incds=0 /nref=48 /ntot=148 /MaxReadThrough="3.07756" /MaxDrop="5.25031" /score="4.55188138" /energy="-14.3" /TU="U2220" /idTUdmin="U2220" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" downshifts complement(2442379) /Source="Nicolas_upshifts" /id="D1469" /incds=0 /nref=27 /ntot=221 /MaxReadThrough="1.51397" /MaxDrop="5.34865" /score="-5.71907967" /energy="-14.3" /TU="NA" /idTUdmin="U2222" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2442381..2442623) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390748.1" /db_xref="EnsemblGenomes-Gn:BSU28700" /db_xref="EnsemblGenomes-Tr:CAB14830" /db_xref="InterPro:IPR025870" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12322" /db_xref="UniProtKB/Swiss-Prot:P94533" /translation="MALNTRESARDITALDIPDTSASNTFEIGFVTENVEAVIKRMRE QGVSIIGEPKVKPWGQTVAYIADPDGHYIEICSPME*" /label="ysfE CDS" gene complement(2442381..2442623) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /label="ysfE gene" S_feature complement(2442624..2442795) /Source="Nicolas_S_feature" /locus_tag="new_2936210_2936381_c" /HighExp="Sw, M0t90, M40t90, M9-stat, T2.0H, BC, T0.30H, Lbstat, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1084" CDS complement(2442683..2442853) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513996.1" /translation="MGADVERSELKDGSIYTGLEGLLKMLRGVGNESINEISYSIRIG QQAGYSFFTGIF*" /label="hypothetical protein CDS" gene complement(2442683..2442853) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /label="gene" CDS complement(2442796..2444592) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 1848300, 17320232, 19682248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 1848300, 17320232, 19682248; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="carbon starvation-induced membrane protein" /protein_id="NP_390749.2" /db_xref="EnsemblGenomes-Gn:BSU28710" /db_xref="EnsemblGenomes-Tr:CAB14831" /db_xref="GOA:P94532" /db_xref="InterPro:IPR003706" /db_xref="InterPro:IPR025299" /db_xref="SubtiList:BG11924" /db_xref="UniProtKB/Swiss-Prot:P94532" /translation="MNAVTIVIASMCILAIAYRLYGTFMMVKVLKVNDDKPTPAHALE DGKDYVPTNKWVSFGHHFAAIAAAGPLVGPILAAQFGYLPGLLWLLIGAVIGGAVHDI VVLFASMRKNGKSLSEVAKDELGPVAGFCTGLSMLFIITITMAGLSMVVLHALERNPW GTFAVGITIPIAMGVGLFYKKTGNLKLASTVGFLFLMAGVFIGPWVQTTALGDFLTLD TKTLAIALPVYAFFAAALPVWLLLAPRDYLSSFMKIGVFIALIVGVFVVNPSIPFPAF TEFVKGGGPVLAGPVWPFISITIACGAISGFHAFVGSGTTPKMLNKWSDMKPVAFGAM LVECLVGIMALIAATALQPADYFAINSTPEVFRTLGMNVVHLPELSGEIGLDLEGRTG GAVTLAVGMTYIFTGMPFFSHLASYFFQFVIMFEAVFILTAIDAGTRVARYLIQDFFG EVYKPLKKTDWIPGSVFASALACLMWGYLLYSGDIGSIWALFGVSNQLMASVGLIIGA TIVLKIADKRRYILTCLIPLAYLYVTVNYAGYWMVRNVYLNPEAAGYSVLNGVLSIIM LVLGFIIIVAAVKKWAQMWKDPSLRMEASIPG*" /label="cstA CDS" gene complement(2442796..2444592) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /label="cstA gene" promotor_-10 complement(2442898..2442916) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2442916) /Source="Nicolas_upshifts" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2442928..2442936) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2444589 /Source="Nicolas_upshifts" /id="D1470" /incds=0 /nref=4 /ntot=49 /MaxReadThrough="0.92122" /MaxDrop="3.18629" /score="12.2066828" /energy="-15.2" /TU="NA" /idTUdmin="U2220" /TUdmin=2068 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2444617..2444636) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2444627) /Source="Nicolas_upshifts" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2444651..2444657) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2444687..2444743) /Source="Nicolas_S_feature" /locus_tag="new_2938273_2938329_c" /HighExp="BC, Sw, M40t90, T1.30H, M0t90, T1.0H, T0.30H, Lbstat, T2.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1085" downshifts complement(2444711) /Source="Nicolas_upshifts" /id="D1471" /incds=0 /nref=12 /ntot=40 /MaxReadThrough="0.655710000000001" /MaxDrop="5.03461" /score="9.68754272" /energy="-10.5" /TU="NA" /idTUdmin="U2224" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2444744..2446246) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12777810, 14973026, 16233670, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12777810, 14973026, 16233670, 18757805; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-L-arabinofuranosidase" /protein_id="NP_390750.2" /db_xref="EnsemblGenomes-Gn:BSU28720" /db_xref="EnsemblGenomes-Tr:CAB14832" /db_xref="GOA:P94531" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11900" /db_xref="UniProtKB/Swiss-Prot:P94531" /translation="MKKARMIVDKEYKIGEVDKRIYGSFIEHMGRAVYEGIYEPDHPE ADEDGFRKDVQSLIKELQVPIIRYPGGNFLSGYNWEDGVGPVENRPRRLDLAWQTTET NEVGTNEFLSWAKKVNTEVNMAVNLGTRGIDAARNLVEYCNHPKGSYWSDLRRSHGYE QPYGIKTWCLGNEMDGPWQIGHKTADEYGRLAAETAKVMKWVDPSIELVACGSSNSGM PTFIDWEAKVLEHTYEHVDYISLHTYYGNRDNNLPNYLARSMDLDHFIKSVAATCDYV KAKTRSKKTINLSLDEWNVWYHSNEADKKVEPWITARPILEDIYNFEDALLVGSLLIT MLQHADRVKIACLAQLVNVIAPIMTEKGGEAWRQPIFYPYMHASVYGRGESLKPLISS PKYDCSDFTDVPYVDAAVVYSEEEETLTIFAVNKAEDQMETEISLRGFESYQIAEHIV LEHQDIKATNQHNRKNVVPHSNGSSSVSENGLTAHFTPLSWNVIRLKKQS*" /label="abfA CDS" gene complement(2444744..2446246) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /label="abfA gene" downshifts complement(2446117) /Source="Nicolas_upshifts" /id="D1472" /incds=1 /nref=7 /ntot=15 /MaxReadThrough="3.81491" /MaxDrop="6.33773" /score="2.73497974" /energy="-14.2" /TU="U2224,U2225" /idTUdmin="U2224" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_no_box complement(2446221..2446321) /Source="Nicolas_upshift_promotors" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2446261) /Source="Nicolas_upshifts" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2446265..2447110) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390751.2" /db_xref="EnsemblGenomes-Gn:BSU28730" /db_xref="EnsemblGenomes-Tr:CAB14833" /db_xref="GOA:P94530" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11912" /db_xref="UniProtKB/Swiss-Prot:P94530" /translation="MLRHSPQFSVYRIALTLFFMMLSLLYLFPIFCLLLGSLKPSSEL LRVGLNLDIDPKVMSFDNYTFLFNGGSIYFKWFFNSLVLGLFTTVLTLFFSSMIGYGL AVYDFKGRNIIFVLVLIIMMVPLEVMMLPLFKLTVGLHLIDSYTGVILPFIVSPVAVF FFRQYALGLPRDLLDSARMDGCTEFGIFFRIMAPLMKPAFGAMIILQSLNSWNNFLWP LIVLRSKEMFTLPIGLSSLLSPYGNNYDMLISGSVFAILPVIIIFLFFQKYFISGLTV GGVKG*" /label="araQ CDS" gene complement(2446265..2447110) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /label="araQ gene" CDS complement(2447111..2448052) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390752.1" /db_xref="EnsemblGenomes-Gn:BSU28740" /db_xref="EnsemblGenomes-Tr:CAB14834" /db_xref="GOA:P94529" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11911" /db_xref="UniProtKB/Swiss-Prot:P94529" /translation="MKPVKTGTVHPVPSAAKQSGWRDLFYSKKAAPYLFTAPFVLSFL VFFLYPIISVFIMSFQRILPGEVSFVGLSNYTALNNPTFYTALWNTLEYTFWTLIVLI PVPLLLAIFLNSKLVKFRNIFKSALFIPALTSTIVAGIIFRLIFGEMETSLANSILLK LGFSPQNWMNNEHTGMFLMVLLASWRWMGINILYFLAGLQNVPKELYEAADIDGANTM KKFLHITLPFLKPVTVYVLTISIIGGFRMFEESYVLWQNNSPGNIGLTLVGYLYQQGL AYNEMGYGAAIGIVLLIVILVVSLISLKLSGSFKGEG*" /label="araP CDS" gene complement(2447111..2448052) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /label="araP gene" CDS complement(2448088..2449389) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="sugar-binding lipoprotein" /protein_id="NP_390753.2" /db_xref="EnsemblGenomes-Gn:BSU28750" /db_xref="EnsemblGenomes-Tr:CAB14835" /db_xref="GOA:P94528" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG11910" /db_xref="UniProtKB/Swiss-Prot:P94528" /translation="MKKMTVCFLVLMMLLTLVIAGCSAEKSSGKSGETELTFWTFNGL HEQFYVEMVKEWNKKYPDRKIKLNTVVYPYGQMHDNLSISLIAGEGVPDIADVELARF SNFLKGSDIPLADLTPLIEKDRDKFVEARLTLYSKNGKLYGLDTHVGTTVMFYNMDVM KKAGVNPDDIKTWDDYHKAGQKVRKVTGKPMGTVETNDSATFLSMISQQNSGYFDKNG KLILNNDTNVKTLQYLKDMINDKTMIPAPGGGHHSEEYYGFMNQGGAASVLMPIWYMG RFIDYMPDLKGKIAIRPLPAWKEGGDRSAGLGGTATVVPKQSKHVELAKEFLAFAKGS EEGNKKLWSVLGFDPLRWDVWSSKELKEKNKYTDYFQNGTGIFSVLLDIKDEINPIYL HEDFAKASDLVNRSVLFDALKSQQKTPKQALDRAAGELKQK*" /label="araN CDS" gene complement(2448088..2449389) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /label="araN gene" CDS complement(2449420..2450604) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /EC_number="1.1.1.261" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-1-phosphate dehydrogenase [NAD+] (catabolic)" /protein_id="NP_390754.1" /db_xref="EnsemblGenomes-Gn:BSU28760" /db_xref="EnsemblGenomes-Tr:CAB14836" /db_xref="GOA:P94527" /db_xref="InterPro:IPR023003" /db_xref="InterPro:IPR032837" /db_xref="SubtiList:BG11909" /db_xref="UniProtKB/Swiss-Prot:P94527" /translation="MNRIAADVQRAFENAGEKTLPIKVEEIVLGKQAADSLLDYVKRK NNQHIVLVCDANTHRIAGIDLENRLNQEGFQAECLIIPENEAGDVTADERSLIHVLIH TKQPTDVMIAVGSGTIHDIVRFAAFQRDLPFISYPTAPSVDGFTSAGAPIILYGTKTT IQTKAPSALFADLDLLKAAPQSMVAAGFGDMLGKITSLADWEISRHLAGEPYSPAGAK IVQEALAACIEHTEDIAMKTETGIRVLMESLLVSGLVMLALDHSRPASGGEHHISHWI EMELMEKKRPQILHGAKVGCAAVLLTDTYRKLAQDDGLNEFSPSRREAIQSAYQTLPR GEVLADWLRSAGGPAYFDEIGVGQDSVKNAFRHAHTLRDRCTGLRIINENKTLINHGL YE*" /label="egsA CDS" gene complement(2449420..2450604) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /label="egsA gene" CDS complement(2450601..2451419) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /EC_number="3.1.3.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 14973026, 21575135, 22720735, 25848029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 14973026, 21575135, 22720735, 25848029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycolytic and pentose phosphate intermediates phosphatase" /protein_id="NP_390755.1" /db_xref="EnsemblGenomes-Gn:BSU28770" /db_xref="EnsemblGenomes-Tr:CAB14837" /db_xref="GOA:P94526" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11908" /db_xref="UniProtKB/Swiss-Prot:P94526" /translation="MRIMASHDTPVSPAGILIDLDGTVFRGNELIEGAREAIKTLRRM GKKIVFLSNRGNISRAMCRKKLLGAGIETDVNDIVLSSSVTAAFLKKHYRFSKVWVLG EQGLVDELRLAGVQNASEPKEADWLVISLHETLTYDDLNQAFQAAAGGARIIATNKDR SFPNEDGNAIDVAGMIGAIETSAQAKTELVVGKPSWLMAEAACTAMGLSAHECMIIGD SIESDIAMGKLYGMKSALVLTGSAKQGEQRLYTPDYVLDSIKDVTKLAEEGILI*" /label="araL CDS" gene complement(2450601..2451419) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /label="araL gene" CDS complement(2451397..2452086) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /EC_number="5.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10417639, 11418559, 11732895, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulose-5-phosphate 4-epimerase" /protein_id="NP_390756.1" /db_xref="EnsemblGenomes-Gn:BSU28780" /db_xref="EnsemblGenomes-Tr:CAB14838" /db_xref="GOA:P94525" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR004661" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG11906" /db_xref="UniProtKB/Swiss-Prot:P94525" /translation="MLETLKKEVLAANLKLQEHQLVTFTWGNVSGIDREKERIVIKPS GVEYSDLTADDLVVLNLDGEVVEGSLKPSSDTPTHVYLYKAFPNIGGIVHTHSQWATS WAQSGRDIPPLGTTHADYFDSAIPCTREMYDEEIIHDYELNTGKVIAETFQHHNYEQV PGVLVNNHGPFCWGTDALNAIHNAVVLETVAEMAYHSIMLNKDVTPINTVLHEKHFYR KHGANAYYGQS*" /label="araD CDS" gene complement(2451397..2452086) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /label="araD gene" CDS complement(2452103..2453785) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /EC_number="2.7.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 173711, 4910050, 10417639, 11418559, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulokinase" /protein_id="NP_390757.1" /db_xref="EnsemblGenomes-Gn:BSU28790" /db_xref="EnsemblGenomes-Tr:CAB14839" /db_xref="GOA:P94524" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005929" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG11905" /db_xref="UniProtKB/Swiss-Prot:P94524" /translation="MAYTIGVDFGTLSGRAVLVHVQTGEELAAAVKEYRHAVIDTVLP KTGQKLPRDWALQHPADYLEVLETTIPSLLEQTGVDPKDIIGIGIDFTACTILPIDSS GQPLCMLPEYEEEPHSYVKLWKHHAAQKHADRLNQIAEEEGEAFLQRYGGKISSEWMI PKVMQIAEEAPHIYEAADRIIEAADWIVYQLCGSLKRSNCTAGYKAMWSEKAGYPSDD FFEKLNPSMKTITKDKLSGSIHSVGEKAGSLTEKMAKLTGLLPGTAVAVANVDAHVSV PAVGITEPGKMLMIMGTSTCHVLLGEEVHIVPGMCGVVDNGILPGYAGYEAGQSCVGD HFDWFVKTCVPPAYQEEAKEKNIGVHELLSEKANHQAPGESGLLALDWWNGNRSTLVD ADLTGMLLGMTLLTKPEEIYRALVEATAYGTRMIIETFKESGVPIEELFAAGGIAEKN PFVMQIYADVTNMDIKISGSPQAPALGSAIFGALAAGKEKGGYDDIKKAAANMGKLKD ITYTPNAENAAVYEKLYAEYKELVHYFGKENHVMKRLKTIKNLQFSSAAKKN*" /label="araB CDS" gene complement(2452103..2453785) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /label="araB gene" CDS complement(2453799..2455289) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /EC_number="5.3.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 10669396, 11418559, 14973026, 18263741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 10669396, 11418559, 14973026, 18263741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-arabinose isomerase" /protein_id="NP_390758.2" /db_xref="EnsemblGenomes-Gn:BSU28800" /db_xref="EnsemblGenomes-Tr:CAB14840" /db_xref="GOA:P94523" /db_xref="InterPro:IPR003762" /db_xref="InterPro:IPR004216" /db_xref="InterPro:IPR009015" /db_xref="InterPro:IPR024664" /db_xref="SubtiList:BG11904" /db_xref="UniProtKB/Swiss-Prot:P94523" /translation="MLQTKDYEFWFVTGSQHLYGEETLELVDQHAKSICEGLSGISSR YKITHKPVVTSPETIRELLREAEYSETCAGIITWMHTFSPAKMWIEGLSSYQKPLMHL HTQYNRDIPWGTIDMDFMNSNQSAHGDREYGYINSRMGLSRKVIAGYWDDEEVKKEMS QWMDTAAALNESRHIKVARFGDNMRHVAVTDGDKVGAHIQFGWQVDGYGIGDLVEVMD RITDDEVDTLYAEYDRLYVISEETKRDEAKVASIKEQAKIELGLTAFLEQGGYTAFTT SFEVLHGMKQLPGLAVQRLMEKGYGFAGEGDWKTAALVRMMKIMAKGKRTSFMEDYTY HFEPGNEMILGSHMLEVCPTVALDQPKIEVHSLSIGGKEDPARLVFNGISGSAIQASI VDIGGRFRLVLNEVNGQEIEKDMPNLPVARVLWKPEPSLKTAAEAWILAGGAHHTCLS YELTAEQMLDWAEMAGIESVLISRDTTIHKLKHELKWNEALYRLQK*" /label="araA CDS" gene complement(2453799..2455289) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /label="araA gene" promotor_-10 complement(2455382..2455401) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2455389) /Source="Nicolas_upshifts" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2455391..2455466) /Source="Nicolas_S_feature" /locus_tag="new_2948977_2949052_c" /HighExp="M9-stat, T1.30H, T2.0H, T2.30H, T3.0H, T4.0H, T3.30H, T1.0H, BC, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1086" promotor_-35 complement(2455416..2455423) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2455467..2456438) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 15556708, 17827291, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 15556708, 17827291, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan-endo-1,5-alpha-L-arabinase" /protein_id="NP_390759.2" /db_xref="EnsemblGenomes-Gn:BSU28810" /db_xref="EnsemblGenomes-Tr:CAB14841" /db_xref="GOA:P94522" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR016840" /db_xref="InterPro:IPR023296" /db_xref="PDB:1UV4" /db_xref="SubtiList:BG11901" /db_xref="UniProtKB/Swiss-Prot:P94522" /translation="MKKKKTWKRFLHFSSAALAAGLIFTSAAPAEAAFWGASNELLHD PTMIKEGSSWYALGTGLTEERGLRVLKSSDAKNWTVQKSIFTTPLSWWSNYVPNYGQN QWAPDIQYYNGKYWLYYSVSSFGSNTSAIGLASSTSISSGGWKDEGLVIRSTSSNNYN AIDPELTFDKDGNPWLAFGSFWSGIKLTKLDKSTMKPTGSLYSIAARPNNGGALEAPT LTYQNGYYYLMVSFDKCCDGVNSTYKIAYGRSKSITGPYLDKSGKSMLEGGGTILDSG NDQWKGPGGQDIVNGNILVRHAYDANDNGIPKLLINDLNWSSGWPSY*" /label="abnA CDS" gene complement(2455467..2456438) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /label="abnA gene" S_feature complement(2456439..2456567) /Source="Nicolas_S_feature" /locus_tag="new_2950025_2950153_c" /HighExp="M9-stat, BC, T2.0H, T2.30H, T3.0H, S8, T1.30H, T3.30H, M0t90, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1087" promotor_-10 complement(2456552..2456571) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-10" upshifts complement(2456567) /Source="Nicolas_upshifts" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="upshifts" promotor_-35 complement(2456586..2456589) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-35" CDS complement(2456635..2457720) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15375159, 16021622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fructose-lysine aminopeptidase" /protein_id="NP_390760.1" /db_xref="EnsemblGenomes-Gn:BSU28820" /db_xref="EnsemblGenomes-Tr:CAB14842" /db_xref="GOA:P94521" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="PDB:1VHE" /db_xref="SubtiList:BG12317" /db_xref="UniProtKB/Swiss-Prot:P94521" /translation="MAKLDETLTMLKDLTDAKGIPGNEREVRQVMKSYIEPFADEVTT DRLGSLIAKKTGAENGPKIMIAGHLDEVGFMVTQITDKGFIRFQTVGGWWAQVMLAQR VTIVTKKGEITGVIGSKPPHILSPEARKKSVEIKDMFIDIGASSREEALEWGVLPGDM IVPHFEFTVMNNEKFLLAKAWDNRIGCAIAIDVLRNLQNTDHPNIVYGVGTVQEEVGL RGAKTAAHTIQPDIAFGVDVGIAGDTPGISEKEAQSKMGKGPQIIVYDASMVSHKGLR DAVVATAEEAGIPYQFDAIAGGGTDSGAIHLTANGVPALSITIATRYIHTHAAMLHRD DYENAVKLITEVIKKLDRKTVDEITYQ*" /label="frvX CDS" gene complement(2456635..2457720) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /label="frvX gene" downshifts complement(2456649) /Source="Nicolas_upshifts" /id="D1473" /incds=0 /nref=233 /ntot=262 /MaxReadThrough="3.55686" /MaxDrop="6.91328" /score="-0.475558157" /energy="-9.9" /TU="U2227" /idTUdmin="U2227" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2457746..2457765) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-10" upshifts complement(2457769) /Source="Nicolas_upshifts" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="upshifts" promotor_-35 complement(2457780..2457787) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-35" promotor_-35 2457838..2457847 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2457853 /Source="Nicolas_upshifts" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2457859..2457874 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2457904..2458296 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10960106, 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390761.1" /db_xref="EnsemblGenomes-Gn:BSU28830" /db_xref="EnsemblGenomes-Tr:CAB14843" /db_xref="GOA:P94520" /db_xref="SubtiList:BG12316" /db_xref="UniProtKB/Swiss-Prot:P94520" /translation="MFVMVLRIILLALFAYCIYAVVKYVANPKRRLKLAQSKEHFYII DEQNNTRKNFQLTYKGVLFEGEKHIPSKDHPLFIHTIFVWTESPEKLKHFSAKDFENI EEKVLERYPNCKIDWDQPIKLAKKAEER*" /label="ysdB CDS" gene 2457904..2458296 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /label="ysdB gene" downshifts 2458267 /Source="Nicolas_upshifts" /id="D1474" /incds=0 /nref=86 /ntot=229 /MaxReadThrough="5.09744" /MaxDrop="4.57118" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-2112" /isTUend="FALSE" /label="downshifts" S_feature 2458312..2458618 /Source="Nicolas_S_feature" /locus_tag="new_2951898_2952204" /HighExp="Etha, M9-stat, T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, S8, T3.30H, Salt" /AntisenseName="ysdA" /AntisenseCor="-0.31305612685159701" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1088" CDS complement(2458312..2458581) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17289755; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_390762.1" /db_xref="EnsemblGenomes-Gn:BSU28840" /db_xref="EnsemblGenomes-Tr:CAB14844" /db_xref="GOA:P94519" /db_xref="InterPro:IPR010718" /db_xref="SubtiList:BG12315" /db_xref="UniProtKB/Swiss-Prot:P94519" /translation="MIIAAYLVLINLCGFWVMGIDKRKAQQHKWRISEDRLWLIAIVF GALGVWLGMQTFRHKTKHASFKYGVPLLLVIEAILIAIYYSPFDL*" /label="ysdA CDS" gene complement(2458312..2458581) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /label="ysdA gene" downshifts complement(2458328) /Source="Nicolas_upshifts" /id="D1475" /incds=0 /nref=6 /ntot=206 /MaxReadThrough="2.53274" /MaxDrop="3.80421" /score="20.1281719" /energy="-14" /TU="U2229" /idTUdmin="U2230" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" downshifts complement(2458497) /Source="Nicolas_upshifts" /id="D1476" /incds=1 /nref=1 /ntot=37 /MaxReadThrough="4.90568" /MaxDrop="2.19601" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 2458575 /Source="Nicolas_upshifts" /id="D1477" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="4.08794" /MaxDrop="3.37039" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-1804" /isTUend="FALSE" /label="downshifts" CDS complement(2458638..2458997) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L20" /protein_id="NP_390763.1" /db_xref="EnsemblGenomes-Gn:BSU28850" /db_xref="EnsemblGenomes-Tr:CAB14845" /db_xref="GOA:P55873" /db_xref="InterPro:IPR005813" /db_xref="InterPro:IPR035566" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11971" /db_xref="UniProtKB/Swiss-Prot:P55873" /translation="MPRVKGGTVTRKRRKKVLKLAKGYFGSKHTLYKVANQQVMKSGN YAFRDRRQKKRDFRKLWITRINAAARMNGLSYSRLMHGLKLSGIEVNRKMLADLAVND LTAFNQLADAAKAQLNK*" /label="rplT CDS" gene complement(2458638..2458997) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /label="rplT gene" downshifts complement(2458651) /Source="Nicolas_upshifts" /id="D1478" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="5.94351" /MaxDrop="6.27682" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" CDS complement(2459029..2459229) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L35" /protein_id="NP_390764.1" /db_xref="EnsemblGenomes-Gn:BSU28860" /db_xref="EnsemblGenomes-Tr:CAB14846" /db_xref="GOA:P55874" /db_xref="InterPro:IPR001706" /db_xref="InterPro:IPR018265" /db_xref="InterPro:IPR021137" /db_xref="InterPro:IPR037229" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11972" /db_xref="UniProtKB/Swiss-Prot:P55874" /translation="MPKMKTHRGSAKRFKKTGSGKLKRSHAYTSHLFANKSQKQKRKL RKSAVVSAGDFKRIKQMLANIK*" /label="rpmI CDS" gene complement(2459029..2459229) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /label="rpmI gene" CDS complement(2459242..2459763) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-3" /protein_id="NP_390765.1" /db_xref="EnsemblGenomes-Gn:BSU28870" /db_xref="EnsemblGenomes-Tr:CAB14847" /db_xref="GOA:P55872" /db_xref="InterPro:IPR001288" /db_xref="InterPro:IPR019813" /db_xref="InterPro:IPR019814" /db_xref="InterPro:IPR019815" /db_xref="InterPro:IPR036787" /db_xref="InterPro:IPR036788" /db_xref="SubtiList:BG11944" /db_xref="UniProtKB/Swiss-Prot:P55872" /translation="MISKDQLVNEGIRAREVRLIGQNGDQLGIKSRQEALEIAGRANL DLVLVAANAKPPVCRIMDYGKFRFEQQKKEKEARKNQKIINLKEVRLSPTIDEHDFNT KLRNAIKFLEKGDKVKASIRFKGRAITHKEIGQRVLDRFSEACAEVATVETKPKMDGR SMFLMLAPKNEKQ*" /label="infC CDS" gene complement(2459242..2459763) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /label="infC gene" misc_RNA complement(2459825..2459964) /locus_tag="BSU_misc_RNA_47" /product="mRNA L20_leader attenuator sequence" /experiment="publication(s) with functional evidences, PMID:17289755, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17289755, 23611891" /label="mRNA L20 leader attenuator sequence" gene complement(2459825..2459964) /locus_tag="BSU_misc_RNA_47" /label="gene" promotor_-10 complement(2459961..2459980) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2459971) /Source="Nicolas_upshifts" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2459973..2460037) /Source="Nicolas_S_feature" /locus_tag="new_2953559_2953623_c" /HighExp="Paraq, G180, G150, G135, H2O2, LPh, C30, Oxctl, LBGexp, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1089" promotor_-35 complement(2459994..2460001) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2460019..2460038) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2460037) /Source="Nicolas_upshifts" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2460054..2460058) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2460156..2460163 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2460177..2460195 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2460177 /Source="Nicolas_upshifts" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="upshifts" CDS 2460209..2460874 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /function="14: Cell envelope" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390767.2" /db_xref="EnsemblGenomes-Gn:BSU28890" /db_xref="EnsemblGenomes-Tr:CAB14849" /db_xref="SubtiList:BG12314" /db_xref="UniProtKB/Swiss-Prot:P94517" /translation="MNKLIQLALFFTLMLTGCSNSSTSSESKVETTVKTTAAFPQKEL EKELKKLKPVSLDMKFESPLATELGKRKAKEEAEKQRQIAAEKKLEKEREAKRKKQQE EKAERQRLAEQQAAERQRLAEAERQAELERQRQAAIQKEQKANAEKKRQSQAQRQQTE APSSNSQDPPSSSSQTDKTIQQPASELPDDDGYGYEERKKWHDDQVEWGIKQGYIDPE DAP*" /label="yscB CDS" gene 2460209..2460874 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /label="yscB gene" downshifts 2460852 /Source="Nicolas_upshifts" /id="D1479" /incds=0 /nref=27 /ntot=178 /MaxReadThrough="2.51181" /MaxDrop="3.43861" /score="13.4996084" /energy="-15.8" /TU="NA" /idTUdmin="U2231" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2460906..2461601) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /function="16.5: Explore" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pyruvate import system subunit B" /protein_id="NP_390768.1" /db_xref="EnsemblGenomes-Gn:BSU28900" /db_xref="EnsemblGenomes-Tr:CAB14850" /db_xref="GOA:P94516" /db_xref="InterPro:IPR007300" /db_xref="InterPro:IPR024891" /db_xref="SubtiList:BG12312" /db_xref="UniProtKB/Swiss-Prot:P94516" /translation="MESTMSPYFGIVVSLAAFGIGTFLFKKTKGFFLFTPLFVAMVLG IAFLKIGGFSYADYNNGGEIIKFFLEPATIAFAIPLYKQRDKLKKYWWQIMASIIAGS ICSVTIVYLLAKGIHLDSAVMKSMLPQAATTAIALPLSKGIGGISDITAFAVIFNAVI VYALGALFLKVFKVKNPISKGLALGTSGHALGVAVGIEMGEVEAAMASIAVVVVGVVT VLVIPVFVQLIGG*" /label="pftB CDS" gene complement(2460906..2461601) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /label="pftB gene" downshifts complement(2460928) /Source="Nicolas_upshifts" /id="D1480" /incds=0 /nref=19 /ntot=45 /MaxReadThrough="1.25312" /MaxDrop="6.13174" /score="49.3872074" /energy="-13.7" /TU="NA" /idTUdmin="U2232" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2460972) /Source="Nicolas_upshifts" /id="D1481" /incds=1 /nref=2 /ntot=36 /MaxReadThrough="6.79502" /MaxDrop="3.1016" /score="49.3872074" /energy="-13.7" /TU="U2232" /idTUdmin="U2232" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(2461623..2462063) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15659658, 17452642, 26060272, 27422364, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15659658, 17452642, 26060272, 27422364, 28974613; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyruvate uptake system subunit A" /protein_id="NP_390769.1" /db_xref="EnsemblGenomes-Gn:BSU28910" /db_xref="EnsemblGenomes-Tr:CAB14851" /db_xref="GOA:P94515" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023736" /db_xref="SubtiList:BG12311" /db_xref="UniProtKB/Swiss-Prot:P94515" /translation="MSAKKVYGFLTQAFIFAVIMLVSNMIAAIVPIPIPASVVGLVLL FLLLCLKVIKLEQVETLGTSLTSLIGFLFVPSGISVMNSLGVMQQYGLQIVLVILLAT IILLGATGLFSQLILSLSGKRKTEADMKTKTVQSPQNNNELVHH*" /label="pftA CDS" gene complement(2461623..2462063) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /label="pftA gene" promotor_-10 complement(2462085..2462104) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2462104) /Source="Nicolas_upshifts" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2462120..2462123) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2462197..2462922) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LytS]" /protein_id="NP_390770.1" /db_xref="EnsemblGenomes-Gn:BSU28920" /db_xref="EnsemblGenomes-Tr:CAB14852" /db_xref="GOA:P94514" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11953" /db_xref="UniProtKB/Swiss-Prot:P94514" /translation="MLRVLIVDDEMLARDELAYLLKRTNDEMEINEAENIESAFDQMM DQKPDLLFLDVDLSGENGFDIAKRLKKMKHPPAIVFATAYDQYALKAFEVDALDYLTK PFDEERIQQTLKKYKKVNRDIVETEQNSHAGQHKLALSVGESIVIVDTKDIIYAGTED GHVNVKTFDHSYTVSDTLVVIEKKLPDSDFIRVHRSFVVNTEYIKEIQPWFNSTYNLI MKDGSKIPVSRTYAKELKKLLHI*" /label="lytT CDS" gene complement(2462197..2462922) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /label="lytT gene" downshifts complement(2462226) /Source="Nicolas_upshifts" /id="D1482" /incds=0 /nref=231 /ntot=256 /MaxReadThrough="-0.0173499999999995" /MaxDrop="6.64673" /score="-8.47161605" /energy="-8.9" /TU="NA" /idTUdmin="U2232" /TUdmin="-1298" /isTUend="FALSE" /label="downshifts" CDS complement(2462900..2464681) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /function="16.3: Control" /function="16.13: Shape" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LytT]" /protein_id="NP_390771.1" /db_xref="EnsemblGenomes-Gn:BSU28930" /db_xref="EnsemblGenomes-Tr:CAB14853" /db_xref="GOA:P94513" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11952" /db_xref="UniProtKB/Swiss-Prot:P94513" /translation="MIHLMIMMLERVGIIVILGFILAHTKLFRQALQNQDGYKGKAIL ISIFSLFSIISNYTGIEIQRNMIVNNDWVFTIDPSGSIANTRILGVEIGGLLGGPFVG AGIGILAGLHRFSLGGSTALSCAVSSILAGVLAGLIGRYFTKRYRMPTPRIAALVGIG MESLQMIIILLMAKPFSDAWELVSMIGIPMILINGTGSFIFLSIIQAIIRKEEQARAL ETHRVLTIADQTLPFFRQGLNENSCKSVAAIIHKLTGTDAVSLTDKEKILAHVGAGMD HHIPSKSLITGLSKKVIKTGHIMKAISQEEIECTHAECPLHAAIVLPLTSNGNTIGTL KMYFKSPAGLSQVEEELAEGLAMLFSTQLELGEAELQSKLLKDAEIKALQAQVNPHFL FNAINTISALCRTDVEKTRKLLLQLSVYFRSNLQGARQLLIPLSKELNHLNAYLSLEQ ARFPGKYKIELNIDSRLEQIEIPPFVLQVLVENALRHAFPKKQDICKVTVCVLSDDAS VYMKVADNGRGIPPDVLPELGKKPFPSKEGTGTALYNLNQRLIGLFGQQAALHISSEV HKGTEVSFQVPMQQMKEGEEHAQGVNS*" /label="lytS CDS" gene complement(2462900..2464681) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /label="lytS gene" promotor_-35 2464765..2464768 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2464777..2464796) /Source="Nicolas_upshift_promotors" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2464782) /Source="Nicolas_upshifts" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2464783..2464802 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2464790 /Source="Nicolas_upshifts" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="upshifts" CDS 2464848..2465630 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:15479782, 24123841, 25848029, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15479782, 24123841, 25848029, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase" /protein_id="NP_390772.2" /db_xref="EnsemblGenomes-Gn:BSU28940" /db_xref="EnsemblGenomes-Tr:CAB14854" /db_xref="GOA:P94512" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12310" /db_xref="UniProtKB/Swiss-Prot:P94512" /translation="MKAVFFDLDDTLLWDEKSVRTTFAETCLQAEKKYGLAPEEFEAA VREAARELYMSYETYPYTVMIGINPFEGLWSNFSEPISEGFQKLNKIVPEYRRNAWTN GLKALGIDDPAYGEYLGEFFAAERRKRPFVYDETFAVLDQLKGKYELLLLTNGDPSLQ KEKLAGVPELAPYFNEIVISGAFGKGKPDVSIFEHCLKLMNIEKDDAIMVGDNLNTDI LGASRAGIKTVWINRTDKKNETDVKPDYIISSLHDLFPILEK*" /label="ysaA CDS" gene 2464848..2465630 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /label="ysaA gene" downshifts 2465614 /Source="Nicolas_upshifts" /id="D1483" /incds=0 /nref=36 /ntot=265 /MaxReadThrough="1.0046" /MaxDrop="6.73727" /score="35.9560361" /energy="-13.8" /TU="NA" /idTUdmin="U2234" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" downshifts complement(2465664) /Source="Nicolas_upshifts" /id="D1484" /incds=0 /nref=89 /ntot=246 /MaxReadThrough="1.13716" /MaxDrop="6.01766" /score="35.534455" /energy="-13.8" /TU="NA" /idTUdmin="U2235" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2465671..2467602) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8692931, 9826762, 10632708, 15831787, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8692931, 9826762, 10632708, 15831787, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_390773.1" /db_xref="EnsemblGenomes-Gn:BSU28950" /db_xref="EnsemblGenomes-Tr:CAB14855" /db_xref="GOA:P18255" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10362" /db_xref="UniProtKB/Swiss-Prot:P18255" /translation="MSDMVKITFPDGAVKEFAKGTTTEDIAASISPGLKKKSLAGKLN GKEIDLRTPINEDGTVEIITEGSEEGLQIMRHSAAHLLAQAIKRIYKDVKFGVGPVIE NGFYYDVEMDEAITPEDLPKIEKEMKKIVNANLPIVRKEVSREEAKARFAEIGDDLKL ELLDAIPEGETVSIYEQGEFFDLCRGVHVPSTGKIKEFKLLSLAGAYWRGDSKNQMLQ RVYGTAFFKKADLEEHLRMLEEAKERDHRKLGKELKLFANSQKVGQGLPLWLPKGATI RRVIERYIVDKEISLGYEHVYTPVLGSKELYETSGHWDHYQEGMFPPMEMDNETLVLR PMNCPHHMMIYKQDIHSYRELPIRIAELGTMHRYEMSGALSGLQRVRGMTLNDAHIFV RPDQIKDEFIRTVRLIQDVYEDFGLSDYTFRLSYRDPEDTEKYFDDDEMWNKAQSMLK EAMDEIGHDYYEAEGEAAFYGPKLDVQVKTAIGKEETLSTVQLDFLLPERFDLTYIGE DGKQHRPVVIHRGVVSTMERFVAFLIEEHKGALPTWLAPVQFQVIPVSPAVHLDYAKK VQERLQCEGLRVEVDSRDEKIGYKIREAQMQKIPYMLVVGDQEAENGAVNVRKYGEQN SETISLDEFVKKAVAEAKK*" /label="thrS CDS" gene complement(2465671..2467602) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /label="thrS gene" misc_RNA complement(2467646..2467893) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:9098041, 9826762, 1317842, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 9826762, 1317842, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboT RNA" gene complement(2467646..2467893) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /label="tboT gene" promotor_-10 complement(2467649..2467658) /Source="Nicolas_upshift_promotors" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2467649) /Source="Nicolas_upshifts" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2467704) /Source="Nicolas_upshifts" /id="D1485" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="6.71261" /MaxDrop="3.31801" /score="19.160794" /energy="-16.2" /TU="U2236,U2237,U2238,U2241" /idTUdmin="U2239" /TUdmin=221 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2467904..2467923) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2467917) /Source="Nicolas_upshifts" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2467919..2467999) /Source="Nicolas_S_feature" /locus_tag="new_2961505_2961585_c" /HighExp="S3, S4, LoTm, S5, G135, G180, LBGtran, T5.0H, G/S, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1090" promotor_-35 complement(2467939..2467943) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2468000..2468845) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22882546; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation protein" /protein_id="NP_390774.2" /db_xref="EnsemblGenomes-Gn:BSU28960" /db_xref="EnsemblGenomes-Tr:CAB14856" /db_xref="InterPro:IPR014199" /db_xref="SubtiList:BG10361" /db_xref="UniProtKB/Swiss-Prot:P06569" /translation="MLEIIFEDDHDAAAFLHLIQHSDDRNNIIVREGIRKIGIEKANP AFPIQRFMEPILVKFFLECKEDEHMLSLIEETYCFTDQDEQQQILQLAHSIIEGEADD LPFEPLKLSRKQSILDELQTICLEEGVFYIRSFQTFRLGSYYKQLRDITEAAIDEYKM EQEYQNFIQTLRDYVDAKQPRIKKVHIVHDGSFTLWELRYVPEREKMKYIDRRFVRDH PMYIDSHLLAPLISIAPDEVVLYTDQPEHMMARTIQNVFQERVEMLPLHAFTDAEIPV KHSEG*" /label="ytxC CDS" gene complement(2468000..2468845) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /label="ytxC gene" promotor_-10 complement(2468865..2468883) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2468871) /Source="Nicolas_upshifts" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2468899..2468904) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2468924..2469565) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25728272, 27190159; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative osomosensing transporter" /protein_id="NP_390775.1" /db_xref="EnsemblGenomes-Gn:BSU28970" /db_xref="EnsemblGenomes-Tr:CAB14857" /db_xref="GOA:P06568" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG10360" /db_xref="UniProtKB/Swiss-Prot:P06568" /translation="MKRKTAVKWLAVLAGAGLLYWGNKTYLNVSPKEIRVWVLSFGVF APLMFIGISIVRPLVLFPVSVISIAGGLAFGPLLGTLYTLFGSMCASAVSFFAAGLFS AKKNGHYERLEAIQKQMEDNGFFYIFLLRILPINFDFVSYAAGLSNVKALPYFAATAV GIIPGTIALNVLGASFLAGNLPAFFMVLALYIVFISLPFIFRKKMQNLFQESN*" /label="ytxB CDS" gene complement(2468924..2469565) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /label="ytxB gene" CDS complement(2469599..2470534) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 17003052, 17289076, 19255093, 19968790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17003052, 17289076, 19255093, 19968790; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loader" /protein_id="NP_390776.1" /db_xref="EnsemblGenomes-Gn:BSU28980" /db_xref="EnsemblGenomes-Tr:CAB14858" /db_xref="GOA:P06567" /db_xref="InterPro:IPR002611" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009928" /db_xref="InterPro:IPR027417" /db_xref="PDB:2K7R" /db_xref="PDB:4M4W" /db_xref="SubtiList:BG10359" /db_xref="UniProtKB/Swiss-Prot:P06567" /translation="MEPIGRSLQGVTGRPDFQKRLEQMKEKVMKDQDVQAFLKENEEV IDQKMIEKSLNKLYEYIEQSKNCSYCSEDENCNNLLEGYHPKLVVNGRSIDIEYYECP VKRKLDQQKKQQSLMKSMYIQQDLLGATFQQVDISDPSRLAMFQHVTDFLKSYNETGK GKGLYLYGKFGVGKTFMLAAIANELAEKEYSSMIVYVPEFVRELKNSLQDQTLEEKLN MVKTTPVLMLDDIGAESMTSWVRDEVIGTVLQHRMSQQLPTFFSSNFSPDELKHHFTY SQRGEKEEVKAARLMERILYLAAPIRLDGENRRHP*" /label="dnaI CDS" gene complement(2469599..2470534) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /label="dnaI gene" CDS complement(2470562..2471980) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loading protein; replication initiationmembrane attachment protein" /protein_id="NP_390777.1" /db_xref="EnsemblGenomes-Gn:BSU28990" /db_xref="EnsemblGenomes-Tr:CAB14859" /db_xref="GOA:P07908" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="SubtiList:BG10358" /db_xref="UniProtKB/Swiss-Prot:P07908" /translation="MADYWKDVLPVDPYVVKSRSMLQDIDRQIITQLYQPLIGPVAFS LYMTLWGELEQNRLWGGESTHRQLMGMTQSNLKTIHQEQGKLEGIGLLKVYMKESERQ ERLFIYELLPPLRPNEFFEDGMLNVFLYNRVGKTKYQQLKQFFTHPAISEDAKDITRP FNHAFESLQPSEWKLTSDMEETVRLAEGSEYTSVGQSPSYTITEDVFDFDLFLAGLSE TMIPRKAMTQQVRDTIKKLSYLYGIDPLQMQNVVMSAIDERDVITTEALRKAASDWYQ IERNGQLPDLVEKTQPVHLREGEQPAEEDSLDGKLIALLEAISPKKLLQDIADGTEPS KADLKIIEEIMFEQKLEPGVTNVLIYYVMLKTDMKLSKNYIQKIASHWARKKVKTVRE AMKLAIEENRQYLEWAEGKTKSSKRNQKVIREEKLPDWMTEKETASDSESGQQKLHPQ DLEEQKKKMMEEMQKLKKYSAY*" /label="dnaB CDS" gene complement(2470562..2471980) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /label="dnaB gene" promotor_-10 complement(2472009..2472028) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2472017) /Source="Nicolas_upshifts" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2472043..2472046) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2472095..2472553) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16950922, 27920297, 28624879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950922, 27920297, 28624879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of transcription of ribonucleotide reductase nrd genes and operons" /protein_id="NP_390778.1" /db_xref="EnsemblGenomes-Gn:BSU29000" /db_xref="EnsemblGenomes-Tr:CAB14860" /db_xref="GOA:Q45549" /db_xref="InterPro:IPR003796" /db_xref="InterPro:IPR005144" /db_xref="SubtiList:BG13833" /db_xref="UniProtKB/Swiss-Prot:Q45549" /translation="MKCPSCQHNGTRVLDSRPVDDGKSIRRRRECESCHYRFTTFEKV EETPLIVVKKEGVREEFSREKMLRGLIKACEKRPVSLKTLEDMCFDIEKELRNQGCSE VKSELVGEMVMDRLAKIDEVAYVRFASVYRQFKDINVFIDELKDLIKKER*" /label="nrdR CDS" gene complement(2472095..2472553) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /label="nrdR gene" downshifts complement(2472114) /Source="Nicolas_upshifts" /id="D1486" /incds=0 /nref=14 /ntot=175 /MaxReadThrough="4.1553" /MaxDrop="3.90408" /score="12.4797073" /energy="-21.2" /TU="U2239,U2241" /idTUdmin="U2243" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(2472554..2472701) /Source="Nicolas_S_feature" /locus_tag="new_2966140_2966287_c" /HighExp="dia5, dia15, Lbstat, Diami, Heat, M9-stat, M0t90, M40t90, LBGtran, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, SigA" /TUshortPSig="0.998, 0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1091" promotor_-10 complement(2472692..2472711) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-10" upshifts complement(2472701) /Source="Nicolas_upshifts" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="upshifts" S_feature complement(2472703..2472781) /Source="Nicolas_S_feature" /locus_tag="new_2966289_2966367_c" /HighExp="Lbstat, M40t90, Heat, M9-stat, M0t90, G180, S8, S5, T1.30H, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1092" promotor_-35 complement(2472726..2472729) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-35" downshifts complement(2472826) /Source="Nicolas_upshifts" /id="D1487" /incds=0 /nref=204 /ntot=262 /MaxReadThrough="5.70146" /MaxDrop="5.85416" /score="12.4797073" /energy="-21.2" /TU="U2241,U2242,U2243" /idTUdmin="U2242" /TUdmin="-237" /isTUend="FALSE" /label="downshifts" CDS complement(2472827..2473207) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /EC_number="4.1.1.50" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 10844697, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10844697, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine decarboxylase" /protein_id="NP_390779.2" /db_xref="EnsemblGenomes-Gn:BSU29010" /db_xref="EnsemblGenomes-Tr:CAB14861" /db_xref="GOA:O34426" /db_xref="InterPro:IPR003826" /db_xref="InterPro:IPR016067" /db_xref="InterPro:IPR017716" /db_xref="SubtiList:BG13832" /db_xref="UniProtKB/Swiss-Prot:O34426" /translation="METMGRHVISELWGCDFDKLNDMDFIEKTFVNAALKSGAEVREV AFHKFAPQGVSGVVIISESHLTIHSFPEHGYASIDVYTCGDLDPNVAADYIAEALHAD TRENIEIPRGMGPVQIKQAQAKVL*" /label="speD CDS" gene complement(2472827..2473207) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /label="speD gene" S_feature complement(2473208..2473362) /Source="Nicolas_S_feature" /locus_tag="new_2966794_2966948_c" /HighExp="Lbstat, M40t90, M9-stat, T2.0H, T3.0H, M0t90, T3.30H, Sw, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1093" promotor_-10 complement(2473342..2473361) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2473349 /Source="Nicolas_upshifts" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2473350..2473369 /Source="Nicolas_upshift_promotors" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2473362) /Source="Nicolas_upshifts" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2473376..2473382) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2473440..2473451) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2473446..2474468) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /EC_number="1.2.1.59" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NADP-dependent, gluconeogenesis)" /protein_id="NP_390780.1" /db_xref="EnsemblGenomes-Gn:BSU29020" /db_xref="EnsemblGenomes-Tr:CAB14862" /db_xref="GOA:O34425" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12592" /db_xref="UniProtKB/Swiss-Prot:O34425" /translation="MKVKVAINGFGRIGRMVFRKAMLDDQIQVVAINASYSAETLAHL IKYDTIHGRYDKEVVAGEDSLIVNGKKVLLLNSRDPKQLPWREYDIDIVVEATGKFNA KDKAMGHIEAGAKKVILTAPGKNEDVTIVMGVNEDQFDAERHVIISNASCTTNCLAPV VKVLDEEFGIESGLMTTVHAYTNDQKNIDNPHKDLRRARACGESIIPTTTGAAKALSL VLPHLKGKLHGLALRVPVPNVSLVDLVVDLKTDVTAEEVNEAFKRAAKTSMYGVLDYS DEPLVSTDYNTNPHSAVIDGLTTMVMEDRKVKVLAWYDNEWGYSCRVVDLIRHVAARM KHPSAV*" /label="gapB CDS" gene complement(2473446..2474468) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /label="gapB gene" upshifts complement(2473447) /Source="Nicolas_upshifts" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2473466..2473472) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2474512..2474531) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2474543) /Source="Nicolas_upshifts" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2474544..2474551) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2474674..2475054) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HxlR family)" /protein_id="NP_390781.1" /db_xref="EnsemblGenomes-Gn:BSU29030" /db_xref="EnsemblGenomes-Tr:CAB14863" /db_xref="GOA:O34533" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HZT" /db_xref="SubtiList:BG13831" /db_xref="UniProtKB/Swiss-Prot:O34533" /translation="MEKKKYNISVEATLEVIGGKWKCVILCHLTHGKKRTSELKRLMP NITQKMLTQQLRELEADGVINRIVYNQVPPKVEYELSEYGRSLEGILDMLCAWGANHI NRVYGDTFSVLEESVLNDKLKQES*" /label="ytcD CDS" gene complement(2474674..2475054) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /label="ytcD gene" downshifts complement(2474698) /Source="Nicolas_upshifts" /id="D1488" /incds=0 /nref=17 /ntot=164 /MaxReadThrough="1.55675" /MaxDrop="3.64816" /score="18.9828659" /energy="-15.3" /TU="NA" /idTUdmin="U2245" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature complement(2475055..2475185) /Source="Nicolas_S_feature" /locus_tag="new_2968641_2968771_c" /HighExp="dia15, Diami, dia5, LBGstat, G180, Etha, S5, LBGtran, H2O2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1094" promotor_-35 2475110..2475114 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2475130..2475149 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2475131..2475237 /Source="Nicolas_S_feature" /locus_tag="new_2968717_2968823" /HighExp="Diami, G180, G135, LBGstat, G150, LBGexp, Paraq, Oxctl, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1095" upshifts 2475131 /Source="Nicolas_upshifts" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2475175..2475194) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2475185) /Source="Nicolas_upshifts" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2475209..2475216) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2475238..2476428 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390782.1" /db_xref="EnsemblGenomes-Gn:BSU29040" /db_xref="EnsemblGenomes-Tr:CAB14864" /db_xref="GOA:O34367" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13825" /db_xref="UniProtKB/Swiss-Prot:O34367" /translation="MTSANKSNIPALLALAVSAFAIGTTEFISVGLLPLIADDLDIPV TTAGLTVSLYALGVTFGAPILTSLTSSMSRKTLLLWIMFIFIAGNTMAATASSIGILL AARVISAFSHGVFMSIGSTIAADIVPEDKRASAISIMFTGLTVATVTGVPFGTFIGQQ FGWRFAFMVIIAVGIIAFITNGILVPSKLRKGTKTTMRDQLKLVTNSRLLLLFVITAL GYGGTFVVFTYLSPLLQEVTGFKAGTVAVILLGYGIAIAIGNMIGGKLSNRNPIAALF YMFIVQAIVLFVLTFTAPYQAAGLITILCMGLLAFMNVPGLQVYVVMLAERFVPSAVD VASAMNIAAFNAGIALGSYLGGVITDSIGLIHTAWIGGLMVVGAVILTGWSRLMEKRD RQEA*" /label="ytbD CDS" gene 2475238..2476428 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /label="ytbD gene" promotor_-10 complement(2476060..2476078) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2476076) /Source="Nicolas_upshifts" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2476094..2476099) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2476452..2477294 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /EC_number="1.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19585557, 20981419, 28032445, 28130301" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19585557, 20981419, 28032445, 28130301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aldo/keto reductase" /protein_id="NP_390783.1" /db_xref="EnsemblGenomes-Gn:BSU29050" /db_xref="EnsemblGenomes-Tr:CAB14865" /db_xref="GOA:O34678" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3B3D" /db_xref="SubtiList:BG13826" /db_xref="UniProtKB/Swiss-Prot:O34678" /translation="MTTHLQAKATLHNGVEMPWFGLGVFQVEEGSELVNAVKTAIVHG YRSIDTAAIYGNEAGVGEGIREGIEEAGISREDLFITSKVWNADLGYEETLAAFETSL SKLGLDYLDLYLIHWPVEGKYKEAWRALETLYKEGRIKAIGVSNFQIHHLEDLMTAAE IKPMINQVEFHPRLTQKELIRYCQNQGIQMEAWSPLMQGQLLDHPVLADIAQTYNKSV AQIILRWDLQHGIITIPKSTKEHRIKENASVFDFELTQDDMNRIDALNENLRVGPDPD NFDF*" /label="ytbE CDS" gene 2476452..2477294 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /label="ytbE gene" promotor_-35 2477067..2477072 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2477088..2477106 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2477089 /Source="Nicolas_upshifts" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2477287 /Source="Nicolas_upshifts" /id="D1489" /incds=0 /nref=13 /ntot=124 /MaxReadThrough="1.16017" /MaxDrop="5.72508" /score="24.0721062" /energy="-11.4" /TU="NA" /idTUdmin="U2244" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2477327) /Source="Nicolas_upshifts" /id="D1490" /incds=0 /nref=168 /ntot=263 /MaxReadThrough="3.38494" /MaxDrop="6.57333" /score="13.4291259" /energy="-11.4" /TU="NA" /idTUdmin="U2248" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2477336..2477929) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /EC_number="2.7.1.24" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 11886213, 12538896, 12682299, 15044829, 15526298, 17603993; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphocoenzyme A kinase" /protein_id="NP_390784.1" /db_xref="EnsemblGenomes-Gn:BSU29060" /db_xref="EnsemblGenomes-Tr:CAB14866" /db_xref="GOA:O34932" /db_xref="InterPro:IPR001977" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13824" /db_xref="UniProtKB/Swiss-Prot:O34932" /translation="MTLVIGLTGGIASGKSTVANMLIEKGITVIDADIIAKQAVEKGM PAYRQIIDEFGEDILLSNGDIDRKKLGALVFTNEQKRLALNAIVHPAVRQEMLNRRDE AVANREAFVVLDIPLLFESKLESLVDKIIVVSVTKELQLERLMKRNQLTEEEAVSRIR SQMPLEEKTARADQVIDNSGTLEETKRQLDEIMNSWA*" /label="coaE CDS" gene complement(2477336..2477929) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /label="coaE gene" CDS complement(2477945..2478577) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23396918; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="membrane calmodulin-like protein essential for stage III sporulation" /protein_id="NP_390785.2" /db_xref="EnsemblGenomes-Gn:BSU29070" /db_xref="EnsemblGenomes-Tr:CAB14867" /db_xref="GOA:C0SP79" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR014205" /db_xref="SubtiList:BG13823" /db_xref="UniProtKB/Swiss-Prot:C0SP79" /translation="MQMVSILLLALAVSLDSFSVGFTYGLRKMKIPFKAILVIACCSG AVMFISMLIGSFLTKFFPVYVTEKLGGLILVGIGAWVLYQFFKPAKDKEYLLHEKTLL NLEVRSLGIVIHILRKPMSADIDKSGVINGIEAVLLGFALSIDAFGAGIGAAILGFSP IVMSIAVAIMSSLFVSIGINAGHFLSKWKWIDKMAFLPGLLLITIGLWKL*" /label="spcF CDS" gene complement(2477945..2478577) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /label="spcF gene" S_feature complement(2478578..2478742) /Source="Nicolas_S_feature" /locus_tag="new_2972164_2972328_c" /HighExp="LPhT, dia15, Sw, LBGtran, LBGstat, H2O2, Diami, G135, Lbstat, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1096" CDS complement(2478743..2479573) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /EC_number="3.2.2.23" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15109717, 25825434, 28517932; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formamidopyrimidine-DNA glycosylase; 5-hydroxymethyl-uracil DNA-glycosylase" /protein_id="NP_390786.2" /db_xref="EnsemblGenomes-Gn:BSU29080" /db_xref="EnsemblGenomes-Tr:CAB14868" /db_xref="GOA:O34403" /db_xref="InterPro:IPR000214" /db_xref="InterPro:IPR010663" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR012319" /db_xref="InterPro:IPR015886" /db_xref="InterPro:IPR015887" /db_xref="InterPro:IPR020629" /db_xref="InterPro:IPR035937" /db_xref="SubtiList:BG12628" /db_xref="UniProtKB/Swiss-Prot:O34403" /translation="MPELPEVETVRRTLTGLVKGKTIKSVEIRWPNIIKRPAEPEEFA RKLAGETIQSIGRRGKFLLFHLDHYVMVSHLRMEGKYGLHQAEEPDDKHVHVIFTMTD GTQLRYRDVRKFGTMHLFKPGEEAGELPLSQLGPEPDAEEFTSAYLKDRLAKTNRAVK TALLDQKTVVGLGNIYVDEALFRAGVHPETKANQLSDKTIKTLHAEIKNTLQEAIDAG GSTVRSYINSQGEIGMFQLQHFVYGKKDEPCKNCGTMISKIVVGGRGTHFCAKCQTKK *" /label="mutM CDS" gene complement(2478743..2479573) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /label="mutM gene" CDS complement(2479596..2482238) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /EC_number="2.7.7.7" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3125407, 6777244, 9231429, 12081953, 17905985, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3125407, 6777244, 9231429, 12081953, 17905985, 27399782; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase I" /protein_id="NP_390787.1" /db_xref="EnsemblGenomes-Gn:BSU29090" /db_xref="EnsemblGenomes-Tr:CAB14869" /db_xref="GOA:O34996" /db_xref="InterPro:IPR001098" /db_xref="InterPro:IPR002298" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR002562" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR018320" /db_xref="InterPro:IPR019760" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12656" /db_xref="UniProtKB/Swiss-Prot:O34996" /translation="MTERKKLVLVDGNSLAYRAFFALPLLSNDKGVHTNAVYGFAMIL MKMLEDEKPTHMLVAFDAGKTTFRHGTFKEYKGGRQKTPPELSEQMPFIRELLDAYQI SRYELEQYEADDIIGTLAKSAEKDGFEVKVFSGDKDLTQLATDKTTVAITRKGITDVE FYTPEHVKEKYGLTPEQIIDMKGLMGDSSDNIPGVPGVGEKTAIKLLKQFDSVEKLLE SIDEVSGKKLKEKLEEFKDQALMSKELATIMTDAPIEVSVSGLEYQGFNREQVIAIFK DLGFNTLLERLGEDSAEAEQDQSLEDINVKTVTDVTSDILVSPSAFVVEQIGDNYHEE PILGFSIVNETGAYFIPKDIAVESEVFKEWVENDEQKKWVFDSKRAVVALRWQGIELK GAEFDTLLAAYIINPGNSYDDVASVAKDYGLHIVSSDESVYGKGAKRAVPSEDVLSEH LGRKALAIQSLREKLVQELENNDQLELFEELEMPLALILGEMESTGVKVDVDRLKRMG EELGAKLKEYEEKIHEIAGEPFNINSPKQLGVILFEKIGLPVVKKTKTGYSTSADVLE KLADKHDIVDYILQYRQIGKLQSTYIEGLLKVTRPDSHKVHTRFNQALTQTGRLSSTD PNLQNIPIRLEEGRKIRQAFVPSEKDWLIFAADYSQIELRVLAHISKDENLIEAFTND MDIHTKTAMDVFHVAKDEVTSAMRRQAKAVNFGIVYGISDYGLSQNLGITRKEAGAFI DRYLESFQGVKAYMEDSVQEAKQKGYVTTLMHRRRYIPELTSRNFNIRSFAERTAMNT PIQGSAADIIKKAMIDMAAKLKEKQLKARLLLQVHDELIFEAPKEEIEILEKLVPEVM EHALALDVPLKVDFASGPSWYDAK*" /label="polA CDS" gene complement(2479596..2482238) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /label="polA gene" promotor_-10 complement(2482293..2482312) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2482302) /Source="Nicolas_upshifts" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2482326..2482333) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2482362..2482481) /Source="Nicolas_S_feature" /locus_tag="new_2975948_2976067_c" /HighExp="M0t90, M40t90, M9-stat, Lbstat, Sw, T1.30H, T1.0H, S4, S3, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1097" downshifts complement(2482405) /Source="Nicolas_upshifts" /id="D1491" /incds=0 /nref=48 /ntot=175 /MaxReadThrough="5.58383" /MaxDrop="3.85702" /score="15.0073484" /energy="-12.2" /TU="U2249" /idTUdmin="U2254" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2482482..2484221) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_390788.1" /db_xref="EnsemblGenomes-Gn:BSU29100" /db_xref="EnsemblGenomes-Tr:CAB14870" /db_xref="GOA:P23545" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR031967" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3CWF" /db_xref="SubtiList:BG10364" /db_xref="UniProtKB/Swiss-Prot:P23545" /translation="MNKYRVRLFSVFVVCMILVFCVLGLFLQQLFETSDQRKAEEHIE KEAKYLASLLDAGNLNNQANEKIIKDAGGALDVSASVIDTDGKVLYGSNGRSADSQKV QALVSGHEGILSTTDNKLYYGLSLRSEGEKTGYVLLSASEKSDGLKGELWGMLTASLC TAFIVIVYFYSSMTSRYKRSIESATNVATELSKGNYDARTYGGYIRRSDKLGHAMNSL AIDLMEMTRTQEMQRDRLLTVIENIGSGLIMIDGRGFINLVNRSYAKQFHINPNHMLR RLYHDAFEHEEVIQLVEDIFMTETKKCKLLRLPIKIERRYFEVDGVPIMGPDDEWKGI VLVFHDMTETKKLEQMRKDFVANVSHELKTPITSIKGFTETLLDGAMEDKEALSEFLS IILKESERLQSLVQDLLDLSKIEQQNFTLSIETFEPAKMLGEIETLLKHKADEKGISL HLNVPKDPQYVSGDPYRLKQVFLNLVNNALTYTPEGGSVAINVKPREKDIQIEVADSG IGIQKEEIPRIFERFYRVDKDRSRNSGGTGLGLAIVKHLIEAHEGKIDVTSELGRGTV FTVTLKRAAEKSA*" /label="phoR CDS" gene complement(2482482..2484221) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /label="phoR gene" CDS complement(2484214..2484936) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_390789.2" /db_xref="EnsemblGenomes-Gn:BSU29110" /db_xref="EnsemblGenomes-Tr:CAB14871" /db_xref="GOA:P13792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1MVO" /db_xref="SubtiList:BG10363" /db_xref="UniProtKB/Swiss-Prot:P13792" /translation="MNKKILVVDDEESIVTLLQYNLERSGYDVITASDGEEALKKAET EKPDLIVLDVMLPKLDGIEVCKQLRQQKLMFPILMLTAKDEEFDKVLGLELGADDYMT KPFSPREVNARVKAILRRSEIAAPSSEMKNDEMEGQIVIGDLKILPDHYEAYFKESQL ELTPKEFELLLYLGRHKGRVLTRDLLLSAVWNYDFAGDTRIVDVHISHLRDKIENNTK KPIYIKTIRGLGYKLEEPKMNE*" /label="phoP CDS" gene complement(2484214..2484936) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /label="phoP gene" promotor_-10 complement(2485004..2485023) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2485014) /Source="Nicolas_upshifts" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2485016..2485116) /Source="Nicolas_S_feature" /locus_tag="new_2978602_2978702_c" /HighExp="M40t90, T1.30H, T1.0H, M0t90, M9-stat, T2.0H, T2.30H, T3.0H, T0.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1098" promotor_-35 complement(2485037..2485043) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2485148..2486086) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /EC_number="1.1.1.37" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate dehydrogenase (NAD-dependent)" /protein_id="NP_390790.1" /db_xref="EnsemblGenomes-Gn:BSU29120" /db_xref="EnsemblGenomes-Tr:CAB14872" /db_xref="GOA:P49814" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011275" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11386" /db_xref="UniProtKB/Swiss-Prot:P49814" /translation="MGNTRKKVSVIGAGFTGATTAFLIAQKELADVVLVDIPQLENPT KGKALDMLEASPVQGFDAKITGTSNYEDTAGSDIVVITAGIARKPGMSRDDLVSTNEK IMRSVTQEIVKYSPDSIIVVLTNPVDAMTYAVYKESGFPKERVIGQSGVLDTARFRTF VAEELNLSVKDVTGFVLGGHGDDMVPLVRYSYAGGIPLETLIPKERIDAIVERTRKGG GEIVNLLGNGSAYYAPAASLTEMVEAILKDQRRVLPTIAYLEGEYGYEGIYLGVPTIV GGNGLEQIIELELTDYERAQLNKSVESVKNVMKVLS*" /label="mdh CDS" gene complement(2485148..2486086) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /label="mdh gene" downshifts complement(2485161) /Source="Nicolas_upshifts" /id="D1492" /incds=0 /nref=200 /ntot=242 /MaxReadThrough="8.27126" /MaxDrop="7.40884" /score="-0.758981483" /energy="-13.5" /TU="U2251,U2254" /idTUdmin="U2250" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2486130..2487401) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /EC_number="1.1.1.42" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8045898, 9244258, 11290745, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045898, 9244258, 11290745, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isocitrate dehydrogenase" /protein_id="NP_390791.1" /db_xref="EnsemblGenomes-Gn:BSU29130" /db_xref="EnsemblGenomes-Tr:CAB14873" /db_xref="GOA:P39126" /db_xref="InterPro:IPR004439" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="PDB:1HQS" /db_xref="SubtiList:BG10856" /db_xref="UniProtKB/Swiss-Prot:P39126" /translation="MAQGEKITVSNGVLNVPNNPIIPFIEGDGTGPDIWNAASKVLEA AVEKAYKGEKKITWKEVYAGEKAYNKTGEWLPAETLDVIREYFIAIKGPLTTPVGGGI RSLNVALRQELDLFVCLRPVRYFTGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGS EEVQKLISFLQNELNVNKIRFPETSGIGIKPVSEEGTSRLVRAAIDYAIEHGRKSVTL VHKGNIMKFTEGAFKNWGYELAEKEYGDKVFTWAQYDRIAEEQGKDAANKAQSEAEAA GKIIIKDSIADIFLQQILTRPNEFDVVATMNLNGDYISDALAAQVGGIGIAPGANINY ETGHAIFEATHGTAPKYAGLDKVNPSSVILSGVLLLEHLGWNEAADLVIKSMEKTIAS KVVTYDFARLMDGATEVKCSEFGEELIKNMD*" /label="icd CDS" gene complement(2486130..2487401) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /label="icd gene" misc_feature complement(2487186..2487205) /Source="Nicolas_upshift_promotors" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2487198) /Source="Nicolas_upshifts" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2487402..2487484) /Source="Nicolas_S_feature" /locus_tag="new_2980988_2981070_c" /HighExp="T2.30H, M40t90, T1.0H, T-3.40H, HiOs, T3.30H, T3.0H, T0.0H, Lbstat, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1099" upshifts complement(2487484) /Source="Nicolas_upshifts" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="upshifts" S_feature complement(2487486..2487564) /Source="Nicolas_S_feature" /locus_tag="new_2981072_2981150_c" /HighExp="T2.30H, T3.30H, T1.0H, M40t90, T3.0H, Lbstat, M0t90, T0.0H, HiOs, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1100" promotor_-10 complement(2487486..2487505) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-10" promotor_-35 complement(2487521..2487525) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-35" CDS complement(2487565..2488683) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase II" /protein_id="NP_390792.1" /db_xref="EnsemblGenomes-Gn:BSU29140" /db_xref="EnsemblGenomes-Tr:CAB14874" /db_xref="GOA:P39120" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR011278" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG10855" /db_xref="UniProtKB/Swiss-Prot:P39120" /translation="MTATRGLEGVVATTSSVSSIIDDTLTYVGYDIDDLTENASFEEI IYLLWHLRLPNKKELEELKQQLAKEAAVPQEIIEHFKSYSLENVHPMAALRTAISLLG LLDSEADTMNPEANYRKAIRLQAKVPGLVAAFSRIRKGLEPVEPREDYGIAENFLYTL NGEEPSPIEVEAFNKALILHADHELNASTFTARVCVATLSDIYSGITAAIGALKGPLH GGANEGVMKMLTEIGEVENAEPYIRAKLEKKEKIMGFGHRVYKHGDPRAKHLKEMSKR LTNLTGESKWYEMSIRIEDIVTSEKKLPPNVDFYSASVYHSLGIDHDLFTPIFAVSRM SGWLAHILEQYDNNRLIRPRADYTGPDKQKFVPIEERA*" /label="citZ CDS" gene complement(2487565..2488683) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /label="citZ gene" downshifts 2488178 /Source="Nicolas_upshifts" /id="D1493" /incds=1 /nref=2 /ntot=63 /MaxReadThrough="1.41638" /MaxDrop="3.70762" /score="40.6931963" /energy="-9.9" /TU="NA" /idTUdmin="U2252" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" misc_feature 2488525..2488528 /Source="Nicolas_upshift_promotors" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2488533 /Source="Nicolas_upshifts" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2488662 /Source="Nicolas_upshifts" /id="D1494" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="2.98678" /MaxDrop="3.07929" /score="40.6931963" /energy="-9.9" /TU="U2252" /idTUdmin="U2252" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2488684..2488890) /Source="Nicolas_S_feature" /locus_tag="new_2982270_2982476_c" /HighExp="T3.0H, T3.30H, T2.30H, T4.0H, M0t90, T2.0H, T1.30H, T5.0H, BC, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1101" misc_feature 2488858..2488870 /Source="Nicolas_upshift_promotors" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2488869 /Source="Nicolas_upshifts" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2488876..2488895) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2488890) /Source="Nicolas_upshifts" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2488910..2488914) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2489010) /Source="Nicolas_upshifts" /id="D1495" /incds=0 /nref=116 /ntot=204 /MaxReadThrough="6.4946" /MaxDrop="5.00031" /score="29.3344463" /energy="-8.1" /TU="NA" /idTUdmin="U2255" /TUdmin=14 /isTUend="TRUE" /label="downshifts" CDS complement(2489017..2489481) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390793.1" /db_xref="EnsemblGenomes-Gn:BSU29150" /db_xref="EnsemblGenomes-Tr:CAB14875" /db_xref="GOA:O34811" /db_xref="InterPro:IPR007382" /db_xref="SubtiList:BG13933" /db_xref="UniProtKB/Swiss-Prot:O34811" /translation="MFTQANLFLILLLAIALIAKNQSLLFAVSVLLIIKIVGLDQKLF PTIQSKGINWGVTIITIAVLVPIATGEIGFKQLGEAMRSSYAWIALGAGIAVALIAKN GLTLLENDPHITTALVIGTILAVALFGGVAVGPLIGAGIAYLAMQIVKLFTS*" /label="ytwI CDS" gene complement(2489017..2489481) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /label="ytwI gene" promotor_-10 complement(2489494..2489513) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2489508) /Source="Nicolas_upshifts" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2489510..2490695) /Source="Nicolas_S_feature" /locus_tag="new_2983096_2984281_c" /HighExp="G135, G180, LBGstat, G150, LBGtran, S0, Paraq, Oxctl, H2O2, LBGexp" /AntisenseName="ytvI" /AntisenseCor="-0.73323145377324295" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1102" promotor_-35 2489510..2489515 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2489526..2489534) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2489530..2489548 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2489536 /Source="Nicolas_upshifts" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="upshifts" CDS 2489578..2490693 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12662922, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sporulation-related permease" /protein_id="NP_390794.1" /db_xref="EnsemblGenomes-Gn:BSU29160" /db_xref="EnsemblGenomes-Tr:CAB14876" /db_xref="GOA:O34991" /db_xref="InterPro:IPR002549" /db_xref="InterPro:IPR014227" /db_xref="SubtiList:BG13930" /db_xref="UniProtKB/Swiss-Prot:O34991" /translation="MNQSYITIFFRTLFVISMTAGSIAAAYYSFPLTYPFLIALILSS VIHPVVDYLDKVTGFPRTINVLGVLAFFLLAAFGVLTILVAEIVTGTAYLAKTLPPHI STFISYCEKLFTTHIQPLYNELTLLFQELETNQQASIVTHIQTLGDSAAKNAGLLLSH ILEMIPRFFALLPNTAAVLIFSLLATFFMTKDWHKLKAMLVLILPDRVTANSKAISSE LKKAMTGFIKAQAVLVFITMVIVFIGLSLLKVEHAATIAFLIGLVDLLPYLGAGSVFV PWILYLSITGQLPQAIGIGILYLVVLIQRQLTEPKILSKSIGIDPLATLIALFAGFKL FGFLGLIAGPAVLVIIQAFITTGALKEIWSYITVQQK*" /label="ytvI CDS" gene 2489578..2490693 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /label="ytvI gene" downshifts 2490664 /Source="Nicolas_upshifts" /id="D1496" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.639" /MaxDrop="3.31897" /score="37.6858539" /energy="-16.7" /TU="NA" /idTUdmin="U2256" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2490726..2491109) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15302217, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390795.1" /db_xref="EnsemblGenomes-Gn:BSU29170" /db_xref="EnsemblGenomes-Tr:CAB14877" /db_xref="GOA:O32064" /db_xref="InterPro:IPR007313" /db_xref="SubtiList:BG13935" /db_xref="UniProtKB/Swiss-Prot:O32064" /translation="MRFLFLLFIVFPAIEIGIFLFLGNLIGILPTVLFMILTGIIGAA AAKKQGTEVYYKVQRDLQYGKMPGEAIADGLCIFIGGLLLMLPGFLSDLAGACLLIPF TRGWCKPILFKWLRGMSKNKRIIIK*" /label="ytzA CDS" gene complement(2490726..2491109) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /label="ytzA gene" downshifts complement(2490740) /Source="Nicolas_upshifts" /id="D1497" /incds=0 /nref=181 /ntot=256 /MaxReadThrough="4.28884" /MaxDrop="5.74703" /score="18.319512" /energy="-13.8" /TU="NA" /idTUdmin="U2257" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2491110..2491201) /Source="Nicolas_S_feature" /locus_tag="new_2984696_2984787_c" /HighExp="G135, LBGtran, G150, LBGexp, M0t45, Lbexp, S0, G180, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1103" CDS complement(2491202..2492959) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /EC_number="2.7.1.40" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate kinase" /protein_id="NP_390796.1" /db_xref="EnsemblGenomes-Gn:BSU29180" /db_xref="EnsemblGenomes-Tr:CAB14878" /db_xref="GOA:P80885" /db_xref="InterPro:IPR001697" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR011037" /db_xref="InterPro:IPR015793" /db_xref="InterPro:IPR015795" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018209" /db_xref="InterPro:IPR036918" /db_xref="SubtiList:BG12661" /db_xref="UniProtKB/Swiss-Prot:P80885" /translation="MRKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFEEHG ARIKNIREASKKLGKNVGILLDTKGPEIRTHTMENGGIELETGKELIISMDEVVGTTD KISVTYEGLVHDVEQGSTILLDDGLIGLEVLDVDAAKREIKTKVLNNGTLKNKKGVNV PGVSVNLPGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQII PKIENQEGVDNIDAILEVSDGLMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVIT ATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSYPVEAVQTMHNIASR SEEALNYKEILSKRRDQVGMTITDAIGQSVAHTAINLNAAAIVTPTESGHTARMIAKY RPQAPIVAVTVNDSISRKLALVSGVFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDL IVITAGTVGESGTTNLMKVHTVGDIIAKGQGIGRKSAYGPVVVAQNAKEAEQKMTDGA VLVTKSTDRDMIASLEKASALITEEGGLTSHAAVVGLSLGIPVIVGLENATSILTDGQ DITVDASRGAVYQGRASVL*" /label="pyk CDS" gene complement(2491202..2492959) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /label="pyk gene" CDS complement(2493002..2493961) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /EC_number="2.7.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12450869, 12622823, 12682299, 19193632, 20473954, 22198292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450869, 12622823, 12682299, 19193632, 20473954, 22198292; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phosphofructokinase" /protein_id="NP_390797.1" /db_xref="EnsemblGenomes-Gn:BSU29190" /db_xref="EnsemblGenomes-Tr:CAB14879" /db_xref="GOA:O34529" /db_xref="InterPro:IPR000023" /db_xref="InterPro:IPR012003" /db_xref="InterPro:IPR012828" /db_xref="InterPro:IPR015912" /db_xref="InterPro:IPR022953" /db_xref="InterPro:IPR035966" /db_xref="PDB:4A3S" /db_xref="SubtiList:BG12644" /db_xref="UniProtKB/Swiss-Prot:O34529" /translation="MKRIGVLTSGGDSPGMNAAVRAVVRKAIYHDVEVYGIYNGYAGL ISGKIEKLELGSVGDIIHRGGTKLYTARCPEFKTVEGREKGIANLKKLGIEGLVVIGG DGSYMGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSH ERTYVIEVMGRHAGDIALWAGLAGGAESILIPEADYDMHEIIARLKRGHERGKKHSII IVAEGVGSGVEFGKRIEEETNLETRVSVLGHIQRGGSPSAADRVLASRLGAYAVELLL EGKGGRCVGIQNNKLVDHDIIEILETKHTVEQNMYQLSKELSI*" /label="pfkA CDS" gene complement(2493002..2493961) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /label="pfkA gene" S_feature complement(2493962..2494063) /Source="Nicolas_S_feature" /locus_tag="new_2987548_2987649_c" /HighExp="G150, LBGtran, LBGexp, Lbexp, dia0, G180, G135, Oxctl, LBGstat, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1104" promotor_-10 complement(2494052..2494071) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2494063) /Source="Nicolas_upshifts" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2494087..2494091) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2494145..2495122) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase alpha subunit)" /protein_id="NP_390798.1" /db_xref="EnsemblGenomes-Gn:BSU29200" /db_xref="EnsemblGenomes-Tr:CAB14880" /db_xref="GOA:O34847" /db_xref="InterPro:IPR001095" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12557" /db_xref="UniProtKB/Swiss-Prot:O34847" /translation="MAPRLEFEKPVIELQTKIAELKKFTQDSDMDLSAEIERLEDRLA KLQDDIYKNLKPWDRVQIARLADRPTTLDYIEHLFTDFFECHGDRAYGDDEAIVGGIA KFHGLPVTVIGHQRGKDTKENLVRNFGMPHPEGYRKALRLMKQADKFNRPIICFIDTK GAYPGRAAEERGQSEAIAKNLFEMAGLRVPVICIVIGEGGSGGALGLGVGNHLHMLEN STYSVISPEGAAALLWKDSSLAKKAAETMKITAPDLKELGIIDHMIKEVKGGAHHDVK LQASYMDETLKQSLKTLLKLSEEELVQQRYEKYKAIGKVSVEDQYIGVN*" /label="accA CDS" gene complement(2494145..2495122) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /label="accA gene" downshifts complement(2494172) /Source="Nicolas_upshifts" /id="D1498" /incds=0 /nref=48 /ntot=176 /MaxReadThrough="5.40549" /MaxDrop="5.53933" /score="-3.96100458" /energy="-6.8" /TU="U2259,U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2495107..2495979) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /EC_number="6.4.1.2" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 14594796, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase betasubunit)" /protein_id="NP_390799.2" /db_xref="EnsemblGenomes-Gn:BSU29210" /db_xref="EnsemblGenomes-Tr:CAB14881" /db_xref="GOA:C0SP93" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13926" /db_xref="UniProtKB/Swiss-Prot:C0SP93" /translation="MLKDIFTKKKKYASVPSDQAKHDVPEGIMTKCPKCKKIMLTKEL DKNMRVCMNCDYHFPMNAKQRIESLMDEQSFEEFNQGMLSENPLGFPGYLEKLEKDRE KTSLNEAVVTGKGTIGGHPAVVAVMDSSFRMGSMGSVVGEKITLAIEKAKADKVPFII FTASGGARMQEGVLSLMQMAKTSSALKLFSEEQGLIISVMTHPTTGGVSASFASLGDY NFAEPGALIGFAGRRIIEQTIGEKLPEDFQTAEFLLKHGQLDAVIHRDDMKKTLENLL DMHQTGGDIEWLQD*" /label="accD CDS" gene complement(2495107..2495979) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /label="accD gene" promotor_-35 2495941..2495946 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2495962..2495980 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2495966..2497140 /Source="Nicolas_S_feature" /locus_tag="new_2989552_2990726" /HighExp="S5, S8, S6, S7, C30, S4, C90, S3, T5.0H, BC" /AntisenseName="ytsJ" /AntisenseCor="-0.46008986922877199" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1105" upshifts 2495966 /Source="Nicolas_upshifts" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2495980..2496063) /Source="Nicolas_S_feature" /locus_tag="new_2989566_2989649_c" /HighExp="LBGstat, T4.0H, LBGtran, T5.0H, C30, dia15, M9-stat, Oxctl, LBGexp, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1106" promotor_-10 complement(2496052..2496071) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2496063) /Source="Nicolas_upshifts" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2496065..2496217) /Source="Nicolas_S_feature" /locus_tag="new_2989651_2989803_c" /HighExp="Diami, BC, dia15, Sw, dia5, M40t90, H2O2, S2, G/S, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1107" promotor_-35 complement(2496087..2496091) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2496219..2496313) /Source="Nicolas_S_feature" /locus_tag="new_2989805_2989899_c" /HighExp="dia15, LBGtran, LBGstat, Diami, LoTm, C90, GM 120, MG 60, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1108" downshifts complement(2496262) /Source="Nicolas_upshifts" /id="D1499" /incds=0 /nref=52 /ntot=158 /MaxReadThrough="7.72399" /MaxDrop="4.5863" /score="-3.96100458" /energy="-6.8" /TU="U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-2178" /isTUend="FALSE" /label="downshifts" CDS complement(2496314..2497546) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /EC_number="1.1.1.40" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 22740702, 23136871, 24325460, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 22740702, 23136871, 24325460, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP-dependent malic enzyme (conversion of malate into pyruvate, anabolic)" /protein_id="NP_390800.1" /db_xref="EnsemblGenomes-Gn:BSU29220" /db_xref="EnsemblGenomes-Tr:CAB14882" /db_xref="GOA:O34962" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG13922" /db_xref="UniProtKB/Swiss-Prot:O34962" /translation="MSLREEALHLHKVNQGKLESKSKVEVRNAKDLSLAYSPGVAEPC KDIHEDINKVYDYTMKGNMVAVVTDGTAVLGLGNIGPEAALPVMEGKAVLFKSFAGVD AFPIALNTNDVDKIVETVKLLEPTFGGVNLEDIAAPNCFIIEERLKKETNIPVFHDDQ HGTAIVTVAGLVNALKLSGKSMSSIKVVANGAGAAGIAIIKLLHHYGVRDIVMCDSKG AIYEGRPNGMNDVKNEVAKFTNQDRKDGSLKDVIVDADVFIGVSVAGALTKEMVQSMA KDPIIFAMANPNPEIMPEDAREAGASVVGTGRSDFPNQVNNVLAFPGIFRGALDVRAT HINEEMKIAAVEAIASLVSEDELSADYVIPAPFDKRVAPAVAKAVAKAAMETGVARIT VDPEEVAEKTRKLTIIGE*" /label="maeB CDS" gene complement(2496314..2497546) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /label="maeB gene" S_feature complement(2497547..2497663) /Source="Nicolas_S_feature" /locus_tag="new_2991133_2991249_c" /HighExp="dia15, Diami, LBGstat, H2O2, LBGtran, dia5, M40t45, Lbtran, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1109" promotor_-10 complement(2497651..2497670) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2497663) /Source="Nicolas_upshifts" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="upshifts" CDS complement(2497683..2501030) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit), DnaE3" /protein_id="NP_390801.1" /db_xref="EnsemblGenomes-Gn:BSU29230" /db_xref="EnsemblGenomes-Tr:CAB14883" /db_xref="GOA:O34623" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004805" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR029460" /db_xref="SubtiList:BG12583" /db_xref="UniProtKB/Swiss-Prot:O34623" /translation="MSFVHLQVHSGYSLLNSAAAVEELVSEADRLGYASLALTDDHVM YGAIQFYKACKARGINPIIGLTASVFTDDSELEAYPLVLLAKSNTGYQNLLKISSVLQ SKSKGGLKPKWLHSYREGIIAITPGEKGYIETLLEGGLFEQAAQASLEFQSIFGKGAF YFSYQPFKGNQVLSEQILKLSEETGIPVTATGDVHYIRKEDKAAYRCLKAIKAGEKLT DAPAEDLPDLDLKPLEEMQNIYREHPEALQASVEIAEQCRVDVSLGQTRLPSFPTPDG TSADDYLTDICMEGLRSRFGKPDERYLRRLQYELDVIKRMKFSDYFLIVWDFMKHAHE KGIVTGPGRGSAAGSLVAYVLYITDVDPIKHHLLFERFLNPERVSMPDIDIDFPDTRR DEVIQYVQQKYGAMHVAQIITFGTLAAKAALRDVGRVFGVSPKEADQLAKLIPSRPGM TLDEARQQSPQLDKRLRESSLLQQVYSIARKIEGLPRHASTHAAGVVLSEEPLTDVVP LQEGHEGIYLTQYAMDHLEDLGLLKMDFLGLRNLTLIESITSMIEKEENIKIDLSSIS YSDDKTFSLLSKGDTTGIFQLESAGMRSVLKRLKPSGLEDIVAVNALYRPGPMENIPL FIDRKHGRAPVHYPHEDLRSILEDTYGVIVYQEQIMMIASRMAGFSLGEADLLRRAVS KKKKEILDRERSHFVEGCLKKEYSVDTANEVYDLIVKFANYGFNRSHAVAYSMIGCQL AYLKAHYPLYFMCGLLTSVIGNEDKISQYLYEAKGSGIRILPPSVNKSSFPFTVENGS VRYSLRAIKSVGVSAVKDIYKARKEKPFEDLFDFCFRVPSKSVNRKMLEALIFSGAMD EFGQNRATLLASIDVALEHAELFAADDDQMGLFLDESFSIKPKYVETEELPLVDLLAF EKETLGIYFSNHPLSAFRKQLTAQGAVSILQAQRAVKRQLSLGVLLSKIKTIRTKTGQ NMAFLTLSDETGEMEAVVFPEQFRQLSPVLREGALLFTAGKCEVRQDKIQFIMSRAEL LEDMDAEKAPSVYIKIESSQHSQEILAKIKRILLEHKGETGVYLYYERQKQTIKLPES FHINADHQVLYRLKELLGQKNVVLKQW*" /label="dnaEC CDS" gene complement(2497683..2501030) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /label="dnaEC gene" promotor_-35 complement(2497684..2497691) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2498695..2498704 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2498716..2498731 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2498716 /Source="Nicolas_upshifts" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2498904..2498923) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2498923) /Source="Nicolas_upshifts" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2498937..2498944) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2501061..2501080) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2501079) /Source="Nicolas_upshifts" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="upshifts" promotor_-35 complement(2501094..2501101) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2501119..2501124 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-35" upshifts 2501136 /Source="Nicolas_upshifts" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="upshifts" promotor_-10 2501140..2501158 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-10" CDS 2501170..2501511 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="membrane protein involved in a sporulation process" /protein_id="YP_003097771.1" /db_xref="EnsemblGenomes-Gn:BSU29239" /db_xref="EnsemblGenomes-Tr:CAX52677" /db_xref="GOA:C0H3P8" /db_xref="InterPro:IPR025689" /db_xref="UniProtKB/Swiss-Prot:C0H3P8" /translation="MDQEAGFMVNFINSYFIALGVLIGGALIGGLGAYLAGEPPLTAI TKLANRLKIWALVAAIGGTFDAVYSFERGILEGNTRDIFKQLLLIISAMGGAQSGWLI ISWLTQEHLSS*" /label="ytrH CDS" gene 2501170..2501511 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /label="ytrH gene" CDS 2501508..2502011 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="protein involved in sporulation" /protein_id="NP_390802.3" /db_xref="EnsemblGenomes-Gn:BSU29240" /db_xref="EnsemblGenomes-Tr:CAB14884" /db_xref="GOA:O34460" /db_xref="SubtiList:BG13917" /db_xref="UniProtKB/Swiss-Prot:O34460" /translation="MRVPQHYKKPGWQRFFAGMMCGAVISWFFFLFTYGTFQEEQVSL IEKQKEHVKDLNNQISIYQEDLHKLNEDNKRKLLIQSVSVKLLNGDKYKISQPDKTKF EEHVKDDISEVITKDIESVYQTKDLLKRTIENKVYMINEKKYEATVRELIIYTRLTVE LEISFAT*" /label="ytrI CDS" gene 2501508..2502011 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /label="ytrI gene" promotor_-35 2502044..2502047 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2502062..2502081 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2502062 /Source="Nicolas_upshifts" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" CDS 2502113..2502304 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative sporulation-related conserved protein" /protein_id="YP_003097772.1" /db_xref="EnsemblGenomes-Gn:BSU29249" /db_xref="EnsemblGenomes-Tr:CAX52678" /db_xref="UniProtKB/Swiss-Prot:C0H3P9" /translation="MEVYSDRQLAKDQAARLRQGFSAYAETNSLASLIKKELQSHNLQ VYEDLTDFGCWFIPVTDEH*" /label="ytzJ CDS" gene 2502113..2502304 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /label="ytzJ gene" downshifts complement(2502114) /Source="Nicolas_upshifts" /id="D1500" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.45109" /MaxDrop="3.19151" /score="-1.37123732" /energy="-6.5" /TU="NA" /idTUdmin="U2268" /TUdmin=220 /isTUend="FALSE" /label="downshifts" downshifts 2502280 /Source="Nicolas_upshifts" /id="D1501" /incds=0 /nref=15 /ntot=107 /MaxReadThrough="6.88261" /MaxDrop="6.74738" /score="-8.58003897" /energy="-4" /TU="U2265" /idTUdmin="U2264" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2502322..2503263) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /EC_number="3.1.3.7" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17586819, 19553197, 22102036, 26735940, 28894100" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17586819, 19553197, 22102036, 26735940, 28894100; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nanoRNase (oligoribonuclease) (3'->5'short substrates, 5'->3' long substrates), 3',5'-bisphosphate nucleotidase" /protein_id="NP_390803.1" /db_xref="EnsemblGenomes-Gn:BSU29250" /db_xref="EnsemblGenomes-Tr:CAB14885" /db_xref="GOA:O34600" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="PDB:5IPP" /db_xref="PDB:5IUF" /db_xref="PDB:5IZO" /db_xref="PDB:5J21" /db_xref="SubtiList:BG13910" /db_xref="UniProtKB/Swiss-Prot:O34600" /translation="MKTELIRTISLYDTIILHRHVRPDPDAYGSQCGLTEILRETYPE KNIFAVGTPEPSLSFLYSLDEVDNETYEGALVIVCDTANQERIDDQRYPSGAKLMKID HHPNEDPYGDLLWVDTSASSVSEMIYELYLEGKEHGWKLNTKAAELIYAGIVGDTGRF LFPNTTEKTLKYAGELIQYPFSSSELFNQLYETKLNVVKLNGFIFQNVSLSENGAASV FIKKDTLEKFGTTASEASQLVGTLGNISGIRAWVFFVEEDDQIRVRFRSKGPVINGLA RKYNGGGHPLASGASIYSWDEADRILADLETLCKEHE*" /label="nrnA CDS" gene complement(2502322..2503263) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /label="nrnA gene" S_feature 2502325..2502696 /Source="Nicolas_S_feature" /locus_tag="new_2995911_2996282" /HighExp="Lbstat, S2, M0t90, M40t90, nit, ferm, S3, BT, M9-stat, S0" /AntisenseName="nrnA" /AntisenseCor="-0.77648424268923499" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1110" downshifts complement(2502357) /Source="Nicolas_upshifts" /id="D1502" /incds=0 /nref=25 /ntot=163 /MaxReadThrough="3.12169" /MaxDrop="3.09205" /score="22.5196409" /energy="-7.9" /TU="U2268" /idTUdmin="U2269" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2502665..2502674 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2502688..2502707 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2502698..2503092 /Source="Nicolas_S_feature" /locus_tag="new_2996284_2996678" /HighExp="Lbstat, S2, S7, S8, S6, nit, ferm, M0t90, BT, M40t90" /AntisenseName="nrnA" /AntisenseCor="-0.85531073541330804" /AntisenseRegPval="-77.5" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1111" upshifts 2502698 /Source="Nicolas_upshifts" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2503054..2503060 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2503076..2503095 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2503094..2503393 /Source="Nicolas_S_feature" /locus_tag="new_2996680_2996979" /HighExp="Lbstat, S8, S7, S6, S2, Etha, nit, ferm, BT, M0t90" /AntisenseName="nrnA" /AntisenseCor="-0.84034645112995598" /AntisenseRegPval="-72.2" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1112" upshifts 2503094 /Source="Nicolas_upshifts" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2503282..2503301) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2503298) /Source="Nicolas_upshifts" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2503300..2503714) /Source="Nicolas_S_feature" /locus_tag="new_2996886_2997300_c" /HighExp="LBGtran, HiTm, G180, G135, G150, Lbtran, LBGexp, Mt0, Paraq, dia0" /AntisenseName="ytpI" /AntisenseCor="-0.70134306018551296" /AntisenseRegPval="-40.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1113" promotor_-35 complement(2503316..2503319) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2503394..2503696 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390804.1" /db_xref="EnsemblGenomes-Gn:BSU29260" /db_xref="EnsemblGenomes-Tr:CAB14886" /db_xref="GOA:O34922" /db_xref="InterPro:IPR025618" /db_xref="SubtiList:BG13902" /db_xref="UniProtKB/Swiss-Prot:O34922" /translation="MLVLVFLIGLSACFYVYYKVKGVRAKPSLAKEICSAKSSMALGS LVLFYGLNQMILFHSVLTLVIGGIFIVIGAGSAWAGYKAFRHYNPLHAKEAERDHA*" /label="ytpI CDS" gene 2503394..2503696 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /label="ytpI gene" S_feature 2503697..2505492 /Source="Nicolas_S_feature" /locus_tag="new_2997283_2999078" /HighExp="S8, S6, S7, Lbstat, B36, nit, ferm, T1.0H, C30, S5" /AntisenseName="ytoI" /AntisenseCor="-0.55304378374907204" /AntisenseRegPval="-22.2" /CDS_PredictionProba="0.89152299999999995" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1114" CDS complement(2503715..2505034) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26296725" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390805.1" /db_xref="EnsemblGenomes-Gn:BSU29270" /db_xref="EnsemblGenomes-Tr:CAB14887" /db_xref="GOA:O34921" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR010766" /db_xref="InterPro:IPR028979" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13897" /db_xref="UniProtKB/Swiss-Prot:O34921" /translation="MATKHEQILTYIDSLPVGEKISVRRIAKEMKVSEGTAYRAIKEA ENKGFVSTIERVGTIRIEQKKKENIEKLTYAEVVNVIDGQVLGGRAGLHKTLNKFVIG AMELDAMMRYTAAGNLLIVGNRINAHRQALEAGAAVLVTGGFNTDDSIVQLADELELP ILSTSYDTFTVAAMINRAIYDQLIKKEIVLVEDILTPADRTVYLSPKDKLEKWYEKNF ETGHGRFPVVDDQMKIHGILTSKDIAGHDRNASIEKVMTKNPVTVIGKTSVASAAQMM VWEGIEVLPVTDGHQKLIGMISRQDVLKALQMIQKQPQVGEKLDDIVSRGFKDEGDDK EDQTVYEYEVTPQMTNQLGTISYGVFTTILTQAANRFLRSKKRGELVIESITIFFLKP VQMESVIEVKPRILEAGRKFGKMEVEVHSQGHIVSKAMLMVQLMERS*" /label="ytoI CDS" gene complement(2503715..2505034) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /label="ytoI gene" promotor_-10 complement(2505060..2505079) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2505081) /Source="Nicolas_upshifts" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2505094..2505099) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2505210..2506112) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390806.1" /db_xref="EnsemblGenomes-Gn:BSU29280" /db_xref="EnsemblGenomes-Tr:CAB14888" /db_xref="GOA:O34430" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13894" /db_xref="UniProtKB/Swiss-Prot:O34430" /translation="MKKLIVFAFIGLLSQLIDGSLGMAYGVTSTSLLLAFGITPAVAS ASVHLAEVVTTAASGVSHIKFGNVDKQTVYQLVIPGSIGAFLGAAFLSQLPGDVAKPY ISLFLLLLGGYVLIRFLFQYKPALEKKHVPLNRKQSIPLGVIAGFADATGGGGWGPVT TPILLSRKGLSPRKVVGTVDTSEFAIAVSATAGFLISLGWEDVNWLWVFSLMAGGIIA APIAAWLVQKFHPQLMGVLVGGFIILVNARTLINEWIANTAVHPLIYTAIGAIWLSAV LFVLSKIGNRNIVKTAVDVHLKEK*" /label="ytnM CDS" gene complement(2505210..2506112) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /label="ytnM gene" CDS complement(2506131..2507381) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10588044, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10588044, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-alkyl-N-acetyl-metabolite deacetylase" /protein_id="NP_390807.1" /db_xref="EnsemblGenomes-Gn:BSU29290" /db_xref="EnsemblGenomes-Tr:CAB14889" /db_xref="GOA:O34980" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12596" /db_xref="UniProtKB/Swiss-Prot:O34980" /translation="MSLDYWRNIEGSYPYQTTGNDILTLKEESNPVNLSTLEKQLIGI RRHLHQYPELSKEEFETTAFIKKCLKEKGIQIRPTALKTGVFADIAGESEGPAIALRA DIDALPIEEKTGLPYASKHKGIMHACGHDFHTAALLGAAFLLKENQDSLKGKIRLLFQ PAEEAGAGATKVIEDGQLDGIDAVIGLHNKPDIAVGTVGLKTGPLMAAVDRFKVEIEG KGAHAALPHNGFDPIIGASQLIVALQTIVSRNVNPLQSAILTVGKINGGSTWNVIPDT VVIEGTVRTFDSEVRNQVKQRFFAVTEQISAAFSLKANVKWHSGPPPLCNDEAITGLV RDAAHKAKLQVIDPAPSTAGEDFAYYLEHIPGSFAFFGTDGDHDWHHPAFTIDETAII KASYFLYESAKRLLDSNEESKISD*" /label="sndA CDS" gene complement(2506131..2507381) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /label="sndA gene" CDS complement(2507399..2508091) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FMN-riboswitch-binding activator of rib genes" /protein_id="NP_390808.1" /db_xref="EnsemblGenomes-Gn:BSU29300" /db_xref="EnsemblGenomes-Tr:CAB14890" /db_xref="GOA:P94465" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11969" /db_xref="UniProtKB/Swiss-Prot:P94465" /translation="MTIIAGTVVKGKQLGRKLGFPTANVDAKIHGLRNGVYGVLATVN HQFHLGVMNIGVKPTVGSNLEKTLEIFLFDFHRDIYGEKIECSILFKIREERRFDSLE SLTKQIKKDISCVAKRFELIGIMAPNKKESLLSHQELNLPDLCFYKKCNNLYGVNRGV YNVIDNWFFEYGITQVAYRRIYILSFLSFLKEDNPKVSSKYIRFGAGGLADKLNRFIS SYVEESEENILG*" /label="ribR CDS" gene complement(2507399..2508091) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /label="ribR gene" CDS complement(2508138..2509466) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390809.1" /db_xref="EnsemblGenomes-Gn:BSU29310" /db_xref="EnsemblGenomes-Tr:CAB14891" /db_xref="GOA:O34974" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="PDB:1TVL" /db_xref="PDB:1YW1" /db_xref="SubtiList:BG13893" /db_xref="UniProtKB/Swiss-Prot:O34974" /translation="MTRADFIQFGAMIHGVGGTTDGWRHPDVDPSASTNIEFYMKKAQ TAEKGLFSFIFIADGLFISEKSIPHFLNRFEPITILSALASVTKNIGLVGTFSTSFTE PFTISRQLMSLDHISGGRAGWNLVTSPQEGAARNHSKSNLPEHTERYEIAQEHLDVVR GLWNSWEHDAFIHNKKTGQFFDQAKLHRLNHKGKYFQVEGPLNIGRSKQGEPVVFQAG SSETGRQFAAKNADAIFTHSNSLEETKAFYADVKSRAADEGRDPSSVRIFPGISPIVA DTEEEAEKKYREFAELIPIENAVTYLARFFDDYDLSVYPLDEPFPDIGDVGKNAFQST TDRIKREAKARNLTLREVAQEMAFPRTLFIGTPERVASLIETWFNAEAADGFIVGSDI PGTLDAFVEKVIPILQERGLYRQDYRGGTLRENLGLGIPQHQSVLHSSHH*" /label="cmoJ CDS" gene complement(2508138..2509466) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /label="cmoJ gene" CDS complement(2509463..2509744) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redoxin" /protein_id="NP_390810.1" /db_xref="EnsemblGenomes-Gn:BSU29320" /db_xref="EnsemblGenomes-Tr:CAB14892" /db_xref="GOA:O34639" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13892" /db_xref="UniProtKB/Swiss-Prot:O34639" /translation="MSDVVNIVVWSKKGCSYCEEVKNYLNEKGFPFQNIDVSEKEKLR DILQVKYGVRHVPVVEIGRGNQYQGITEIGIEHLDLALANHAQIKEAKR*" /label="cmoI CDS" gene complement(2509463..2509744) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /label="cmoI gene" CDS complement(2509759..2510763) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9836433, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9836433, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390811.1" /db_xref="EnsemblGenomes-Gn:BSU29330" /db_xref="EnsemblGenomes-Tr:CAB14893" /db_xref="GOA:O34846" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG13888" /db_xref="UniProtKB/Swiss-Prot:O34846" /translation="MIRLSILDQSLIGEGETAADTLQHTVKLAQMAEECGYHRFWVAE HHNNDEIAGSAPEVLLGYLAASTRKIRLASGGVMLQHYSSYKVAEQFHLLSALAPGRI DLGVGKAPGGFQLSTDALQAEYKKPVRQFDEKLEELTHFVRDDFPDTHRYAALRPRPQ VDRKPGIFLLGGSTESAISAAKLGISFVFAYFINGEEEVLKEARRAFDAHLPPGSEAE FHLAPAVFAAHTKEEAEKHIVSRESIKVVLKDGRKVNVGSREQAEAYLENVTEPYDII VQKTGIIAGTKEEVAEELTRLSGTYKINDFVIFTPIKNAVEKQLSYQLLSDAVLAAKR *" /label="cmoO CDS" gene complement(2509759..2510763) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /label="cmoO gene" CDS complement(2510760..2511539) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino-acid ABC transporter (ATP-binding protein)" /protein_id="NP_390812.1" /db_xref="EnsemblGenomes-Gn:BSU29340" /db_xref="EnsemblGenomes-Tr:CAB14894" /db_xref="GOA:O34900" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG12604" /db_xref="UniProtKB/Swiss-Prot:O34900" /translation="MIEIKNIHKQFGIHHVLKGINLTVRKGEVVTIIGPSGSGKTTFL RCLNLLERPDEGIISIHDKVINCRFPSKKEVHWLRKQTAMVFQQYHLFAHKTVIENVM EGLTIARKMRKQDAYAVAENELRKVGLQDKLNAYPSQLSGGQKQRVGIARALAIHPDV LLFDEPTAALDPELVGEVLEVMLEIVKTGATMIVVTHEMEFARRVSDQVVFMDEGVIV EQGTPEEVFRHTKKDRTRQFLRRVSPEYLFEPKEHIKEPVI*" /label="tcyN CDS" gene complement(2510760..2511539) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /label="tcyN gene" CDS complement(2511536..2512243) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390813.1" /db_xref="EnsemblGenomes-Gn:BSU29350" /db_xref="EnsemblGenomes-Tr:CAB14895" /db_xref="GOA:O34931" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13887" /db_xref="UniProtKB/Swiss-Prot:O34931" /translation="MQFDFPFIVSAMKEMVKTIPLTLMMAVLPIVFGFLVALGNIIVR IFRIKGLVACSRFYVSFFRSTPAILHIMLIYLGIPPVADQVSSFFHLGWSANEIPVSM FVIMALSLTAGAYLTEIIRSGILAMDTGQVEAAYSIGLTYSQTFRRVILPQALKVSIP NFTNLGIGFLHTTSIAAIVAVPEITGTATIVASDNYAFLEAFIGAAIIYWVLTLILES ANGVLERKAARFQGGTL*" /label="tcyM CDS" gene complement(2511536..2512243) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /label="tcyM gene" CDS complement(2512273..2512992) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390814.1" /db_xref="EnsemblGenomes-Gn:BSU29360" /db_xref="EnsemblGenomes-Tr:CAB14896" /db_xref="GOA:O34315" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13886" /db_xref="UniProtKB/Swiss-Prot:O34315" /translation="MEKAFDMNMIGDFVPTLTAYLPVTLYILTLSLLFGFVLGLFLAL PRIYNIPIVNQLAKVYISFFRGTPIMVQLFIVFYGIPALTGLIGIDTSKMDPFYAAVA TYALSNAAAAAEIIRAGVGSVDKGQTEAAYSIGLSGSQAFRRIVLPQALVQAFPNMGN MVISSLKDTSLAFSIGVMDMSGRGQTLITSSNHSLEVYIALSIVYYAVAVLFEWFFRV AEKRIKKNQTRIVTVFDMNIH*" /label="tcyL CDS" gene complement(2512273..2512992) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /label="tcyL gene" promotor_-35 2512818..2512825 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2512840..2512859 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2512840 /Source="Nicolas_upshifts" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2513014..2513826) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 22720735, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 22720735, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390815.1" /db_xref="EnsemblGenomes-Gn:BSU29370" /db_xref="EnsemblGenomes-Tr:CAB14897" /db_xref="GOA:O34852" /db_xref="InterPro:IPR001638" /db_xref="PDB:2O1M" /db_xref="SubtiList:BG13885" /db_xref="UniProtKB/Swiss-Prot:O34852" /translation="MKTKTAFMAILFSLITVLSACGAGSQTTGAGQKKVQTITVGTGT QFPNICFIDEKGDLTGYDVELIKELDKRLPHYKFTFKTMEFSNLLVSLGQHKVDIVAH QMEKSKEREKKFLFNKVAYNHFPLKITVLQNNDTIRGIEDLKGKRVITSATSNGALVL KKWNEDNGRPFEIAYEGQGANETANQLKSGRADATISTPFAVDFQNKTSTIKEKTVGN VLSNAKVYFMFNKNEQTLSDDIDKALQEIIDDGTLKRLSLKWLGDDYSKEQY*" /label="tcyK CDS" gene complement(2513014..2513826) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /label="tcyK gene" CDS complement(2513840..2514649) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390816.1" /db_xref="EnsemblGenomes-Gn:BSU29380" /db_xref="EnsemblGenomes-Tr:CAB14898" /db_xref="GOA:O34406" /db_xref="InterPro:IPR001638" /db_xref="SubtiList:BG13884" /db_xref="UniProtKB/Swiss-Prot:O34406" /translation="MNKRKGLVLLLSVFALLGGGCSQTNNKTDRQAQTVIVGTGTDFP NIAFLNEKGELTGYDIEVMKAIDKELPQYTFEFKTMDFSNLLTSLGNKKIDVIAHNMA KNKEREKRFLYHKVPYNYSPMYITVKEDNHKIHTLKDLHGKTVIVGATSNAADYITKY NKTHGSPIHLKYAGQGSNDTANQIETGRADATIATPFAVDFQNKTHAFRQKTVGDVLL DTEVYFMFNKGSQTLADDTDQAIKKLEKNGTLKKLSRKWLGADYSKSSFEK*" /label="tcyJ CDS" gene complement(2513840..2514649) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /label="tcyJ gene" CDS complement(2514663..2515199) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyltransferase acting on sulfur compounds" /protein_id="NP_390817.1" /db_xref="EnsemblGenomes-Gn:BSU29390" /db_xref="EnsemblGenomes-Tr:CAB14899" /db_xref="GOA:O34350" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13883" /db_xref="UniProtKB/Swiss-Prot:O34350" /translation="MSDDIFRLATVEDASELLKLVNSAFQPIRQLDIDWPSTRADIQM VSENIEHHSAIVLERDGKLISTITIRFPWESETPPSKYPFVWWFATLPEYKGQGAGSK LLTYVEEKVLRDMLKAPALTLGTSARKHPWLADMYRRRGYEVYFEQEKDGDIGVMMHK VLIPERFNPTLLGAPSWA*" /label="snaA CDS" gene complement(2514663..2515199) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /label="snaA gene" promotor_-35 2515236..2515243 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2515254..2515273) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2515257..2515276 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2515260..2515351 /Source="Nicolas_S_feature" /locus_tag="new_3008846_3008937" /HighExp="dia5, MG 5, UNK1, MG t5, MG 10, B60, dia0, nit, Diami, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1115" upshifts 2515260 /Source="Nicolas_upshifts" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2515270) /Source="Nicolas_upshifts" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2515287..2515294) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2515352..2516278 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of operon snaA-ytnM degrading cysteine-containing compounds (AscR-N-acetylcysteine)" /protein_id="NP_390818.1" /db_xref="EnsemblGenomes-Gn:BSU29400" /db_xref="EnsemblGenomes-Tr:CAB14900" /db_xref="GOA:O35038" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13877" /db_xref="UniProtKB/Swiss-Prot:O35038" /translation="MELRSIKTFHTIVKFGSFYKAAEILNYSQPTISMRMKQLEQDLG VLLFERGKSLQLTKAGKLFYERTGDLLMQYEALKHNLSDLKEEEAGIINIGVSEPTAS LIFPEILKDFLMDYPKITVNIKVDDANTCSQKLLDGTIDFAVCGEPELILENYYHPFF YDTLNVIVSDQHPLAEKKAVHLSDLAEERFIFTPANCPIRLQIEQHLHRELGNRYKKM ELTSSMSHEYYVRENIGISIFTSTAHSKPFNGTKVIPILNLDITPPIGLLTNQKEVHF DRATKDLIARITKRFQQRSKELEGTSDKTITG*" /label="ascR CDS" gene 2515352..2516278 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /label="ascR gene" S_feature complement(2515754..2516283) /Source="Nicolas_S_feature" /locus_tag="new_3009340_3009869_c" /HighExp="Etha, dia15, dia5, H2O2, M9-stat, M40t90, Sw, Gly, M0t90, Cold" /AntisenseName="ytlI" /AntisenseCor="-7.8012588423369304E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1116" downshifts complement(2516328) /Source="Nicolas_upshifts" /id="D1503" /incds=0 /nref=142 /ntot=251 /MaxReadThrough="4.32965" /MaxDrop="5.01142" /score="39.1547987" /energy="-16.5" /TU="U2273" /idTUdmin="U2274" /TUdmin=20 /isTUend="TRUE" /label="downshifts" CDS complement(2516329..2517012) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390819.2" /db_xref="EnsemblGenomes-Gn:BSU29410" /db_xref="EnsemblGenomes-Tr:CAB14901" /db_xref="GOA:Q795U4" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR022877" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13871" /db_xref="UniProtKB/Swiss-Prot:Q795U4" /translation="MKVTYHGHSVITVETKDHHIIFDPFLTGNSLTDIKPEDVKADVI LLTHGHNDHVGDTEQIAKQNNALVIAPNELAVYLGWKGLNVHPMHIGGSRQFDFGKVK LTQAFHGSAITDEENKTITYTGMPAGILLTVEDKTIFHAGDTALFSDMKLIGELNHID LAFLPIGDNFTMGPEDAKLAAEWLRAKQVVPVHYNTFPVIEQDPEAFADSLPGGVGKV MSVGETIEL*" /label="ytkL CDS" gene complement(2516329..2517012) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /label="ytkL gene" S_feature complement(2517013..2517074) /Source="Nicolas_S_feature" /locus_tag="new_3010599_3010660_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, M0t90, M40t90, Salt, LBGtran, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1117" CDS complement(2517075..2517842) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_390820.1" /db_xref="EnsemblGenomes-Gn:BSU29420" /db_xref="EnsemblGenomes-Tr:CAB14902" /db_xref="GOA:O34308" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13870" /db_xref="UniProtKB/Swiss-Prot:O34308" /translation="MRHALITAGSKGLGRKVTETLLAKGYSVTVNYRQDEEAVSRLKE ACPDCLDRLQFVKGDVTKKEDLLRIAEAALNRFGRIDFLINNAGPYIFERKKLADYTD DEWYGMLEGNLSAVFHLFKAVIPIMRKQQFGRIITYGFQGAAHAPGWLHRSAFGAAKV GLASLTKTIAIEEAEFGITANMVCPGDIVGDMKEASIEEARMRIGKEKTPIGRSGTGE DIARIIAFLCEENSDLVTGTVIEATGGLNVINKNQTT*" /label="ytkK CDS" gene complement(2517075..2517842) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /label="ytkK gene" promotor_-10 complement(2517887..2517906) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2517909) /Source="Nicolas_upshifts" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2517922..2517924) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2517969..2518205) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11423008" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390821.3" /db_xref="EnsemblGenomes-Gn:BSU29430" /db_xref="EnsemblGenomes-Tr:CAB14903" /db_xref="SubtiList:BG13938" /db_xref="UniProtKB/Swiss-Prot:O34503" /translation="MKKRKLAWQQEFVKISFIKSRHYSQPTSIMMGGRMMKKEPERYI YDEQESQETTRLISEAYQSGYVDMPDQESSSPAE*" /label="ytzD CDS" gene complement(2517969..2518205) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /label="ytzD gene" downshifts 2518054 /Source="Nicolas_upshifts" /id="D1504" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="0.55049" /MaxDrop="4.17437" /score="-5.88070891" /energy="-8.9" /TU="NA" /idTUdmin="U2271" /TUdmin=1782 /isTUend="FALSE" /label="downshifts" downshifts complement(2518074) /Source="Nicolas_upshifts" /id="D1505" /incds=0 /nref=199 /ntot=288 /MaxReadThrough="5.44889" /MaxDrop="6.29233" /score="21.2322542" /energy="-8.5" /TU="U2274" /idTUdmin="U2274" /TUdmin="-1726" /isTUend="FALSE" /label="downshifts" CDS complement(2518165..2519550) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /EC_number="4.3.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 9890879, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 9890879, 11423008; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate lyase" /protein_id="NP_390822.1" /db_xref="EnsemblGenomes-Gn:BSU29440" /db_xref="EnsemblGenomes-Tr:CAB14904" /db_xref="GOA:O34858" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR009049" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="InterPro:IPR029419" /db_xref="SubtiList:BG12571" /db_xref="UniProtKB/Swiss-Prot:O34858" /translation="MKKLWGGRFQKTPEKWVDEFGASISFDQNLVAEDITGSLAHAAM LKKCGILTAEEELKIREGLNTLLQKAEEGALEFSVDYEDIHLNIEKMLIDEIGPLGGK LHTGRSRNDQVATDMHLYLKNHVGHIIELIEAFQSALIEKAEANVETILPGYTHLQRA QPISFAHHLLAYFWMLERDKERFQDSMKRINKSPLGCGALAGTTFPIDRDYSAELLGF DAIYENSLDGVSDRDFILEFLSNSSMLMMHLSRFSEEIILWCSQEFKFIELDDTYATG SSMMPQKKNPDMAELIRGKTGRVYGDMMGLFTIMKGLPLAYNKDLQEDKEGMFDTVKT VEGSLQIFTGMIQTMTVNKDVMKQATKQDFSNATELADYLAKKGMPFREAHEVVGKLV YTCIERGIYLSDMPFGEFQQASTLFEEDIYTVLDPYYAVEKRMSAGGTGFKQVEQALE KAKACVAAGVC*" /label="argH CDS" gene complement(2518165..2519550) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /label="argH gene" CDS complement(2519547..2520758) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /EC_number="6.3.4.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 11423008, 12963366, 17611193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 11423008, 12963366, 17611193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate synthase" /protein_id="NP_390823.1" /db_xref="EnsemblGenomes-Gn:BSU29450" /db_xref="EnsemblGenomes-Tr:CAB14905" /db_xref="GOA:O34347" /db_xref="InterPro:IPR001518" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018223" /db_xref="InterPro:IPR023434" /db_xref="InterPro:IPR024074" /db_xref="SubtiList:BG12570" /db_xref="UniProtKB/Swiss-Prot:O34347" /translation="MSEQKKVVLAYSGGLDTSVAIKWLQEQGYNVIACCLDVGEGKDL AFVQQKALEVGATNSYVIDAKEEFAQDYALISLQAHTMYEGKYPLVSALSRPLIAKKL VEIAEKEDAQAIAHGCTGKGNDQVRFEVSIKSLNPDLEVIAPVREWQWSREEEIEYAA SRGIPIPINLDSPYSIDQNLWGRANECGILEDPWAAPPEGAYDLTAPLEKTPDTPEVI EIAFEQGVPVSIDGVSYSLSELILKLNEMAGAHGVGRIDHVENRLVGIKSREVYECPG AMTLIKAHKELEDLTLVKEVAHFKPIIEQKMSEIIYNGLWFSPLKDALHAFLKETQKH VTGIVRVKLFKGHAIVEGRKSEYSLYDEKLATYTKDDAFDHHAAIGFIELWGLPTKVN SIVKKKEQIKA*" /label="argG CDS" gene complement(2519547..2520758) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /label="argG gene" S_feature complement(2520759..2520836) /Source="Nicolas_S_feature" /locus_tag="new_3014345_3014422_c" /HighExp="S1, MG 15, T3.0H, T3.30H, T4.0H, T5.0H, BMM, T2.30H, T-0.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1118" promotor_-10 complement(2520829..2520848) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2520835) /Source="Nicolas_upshifts" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2520863..2520870) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2520928..2521440) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15269205, 20054111, 23680484; Product type f: factor" /codon_start=1 /transl_table=11 /product="molybdopterin GTP-binding precursor Z biosynthesis component" /protein_id="NP_390824.1" /db_xref="EnsemblGenomes-Gn:BSU29460" /db_xref="EnsemblGenomes-Tr:CAB14924" /db_xref="GOA:O34457" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008284" /db_xref="InterPro:IPR012245" /db_xref="InterPro:IPR036425" /db_xref="SubtiList:BG12618" /db_xref="UniProtKB/Swiss-Prot:O34457" /translation="MSVQEHKQEAPDIVRCKVITVSDTRTDETDKSGKLMISFLEEAG HHIAAYEIVKDEKDALQRSVLAGCMDEQTDAVLLNGGTGIADRDVTIEAITPLFSKEL PGFGEIFRMLSYTEDIGSAAIMSRATAGVIQHTAVFSTPGSSGAVKLAMNKLIIPELA HVVREIRKDK*" /label="moaB CDS" gene complement(2520928..2521440) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /label="moaB gene" downshifts complement(2520946) /Source="Nicolas_upshifts" /id="D1506" /incds=0 /nref=122 /ntot=221 /MaxReadThrough="1.48097" /MaxDrop="4.78155" /score="25.7910606" /energy="-10.8" /TU="NA" /idTUdmin="U2275" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2521466..2521485) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2521474) /Source="Nicolas_upshifts" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2521499..2521506) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2521525..2522712) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /EC_number="2.7.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8226682, 9811655, 11244084, 16995897, 19019159, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226682, 9811655, 11244084, 16995897, 19019159, 26098117; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetate kinase" /protein_id="NP_390825.1" /db_xref="EnsemblGenomes-Gn:BSU29470" /db_xref="EnsemblGenomes-Tr:CAB14925" /db_xref="GOA:P37877" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR004372" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG10813" /db_xref="UniProtKB/Swiss-Prot:P37877" /translation="MSKIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVFTI SVNGEKNTEVTDIPDHAVAVKMLLNKLTEFGIIKDLNEIDGIGHRVVHGGEKFSDSVL LTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYLY SLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEG GKSIDTSMGFTPLAGVAMGTRSGNIDPALIPYIMEKTGQTADEVLNTLNKKSGLLGIS GFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMSGVDAIIFTAGIGENS VEVRERVLRGLEFMGVYWDPALNNVRGEEAFISYPHSPVKVMIIPTDEEVMIARDVVR LAK*" /label="ackA CDS" gene complement(2521525..2522712) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /label="ackA gene" downshifts complement(2521540) /Source="Nicolas_upshifts" /id="D1507" /incds=0 /nref=13 /ntot=117 /MaxReadThrough="5.03131" /MaxDrop="3.1641" /score="19.2403206" /energy="-9.9" /TU="U2276" /idTUdmin="U2277" /TUdmin=242 /isTUend="FALSE" /label="downshifts" S_feature complement(2522713..2522817) /Source="Nicolas_S_feature" /locus_tag="new_3016299_3016403_c" /HighExp="dia0, Lbexp, LBGtran, Oxctl, LPh, M0t45, HPh, Paraq, H2O2, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1119" promotor_-10 complement(2522802..2522821) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2522817) /Source="Nicolas_upshifts" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2522819..2522948) /Source="Nicolas_S_feature" /locus_tag="new_3016405_3016534_c" /HighExp="S5, S6, S7, S8, S4, dia5, BT, H2O2, dia15, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1120" promotor_-35 complement(2522837..2522841) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2522885..2523088) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513997.1" /translation="MMNGLKKKSKCFKSSLDSRMRSMPKLLLFMLLKTGLDELNPALK HKIQREKPQIVSVHQYKTYSECV*" /label="hypothetical protein CDS" gene complement(2522885..2523088) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /label="gene" promotor_-10 complement(2522946..2522957) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2522948) /Source="Nicolas_upshifts" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2522972..2522978) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2523060..2524049) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid methyltransferase" /protein_id="NP_390826.1" /db_xref="EnsemblGenomes-Gn:BSU29480" /db_xref="EnsemblGenomes-Tr:CAB14926" /db_xref="GOA:P37876" /db_xref="InterPro:IPR003356" /db_xref="InterPro:IPR016843" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10812" /db_xref="UniProtKB/Swiss-Prot:P37876" /translation="MQKDHVGAVYELLNEAAIMIKNELQISYIEALAEAGEMYFLEKT DQLKLPADQKTKQLQALLEKAEFGTYEHEWVRKAFQLAVLKGMKDISHPNRQMTPDTI GLFISYLVNKFMADKKELTILDPALGTGNLLFTVLNQLSEKTANSFGIEIDDVLLKIA YAQANLLKKELELFHQDSLEPLFIDPVDTVICDLPVGYYPNDEGAEAFELKADEGHSF AHHLFIEQSVKHTKPGGYLFFMIPNHLFESSQSGKLKQFFKDKVHINALLQLPKSIFK DEAHAKSILVLQKQGENTKAPGQILLANLPSFSNQKAMLDMMAQFDEWFKKEK*" /label="ytxK CDS" gene complement(2523060..2524049) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /label="ytxK gene" downshifts complement(2523078) /Source="Nicolas_upshifts" /id="D1508" /incds=0 /nref=158 /ntot=243 /MaxReadThrough="3.51469" /MaxDrop="5.25938" /score="-4.33730173" /energy="-13.3" /TU="NA" /idTUdmin="U2279" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" CDS complement(2524110..2524613) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486061, 18588855, 18588855, 23899494, 25355936, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486061, 18588855, 18588855, 23899494, 25355936, 25852656; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol peroxidase (lipid hydroperoxide reductase)" /protein_id="NP_390827.1" /db_xref="EnsemblGenomes-Gn:BSU29490" /db_xref="EnsemblGenomes-Tr:CAB14927" /db_xref="GOA:P80864" /db_xref="InterPro:IPR002065" /db_xref="InterPro:IPR013740" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR018219" /db_xref="InterPro:IPR036249" /db_xref="PDB:2JSY" /db_xref="PDB:2JSZ" /db_xref="SubtiList:BG13855" /db_xref="UniProtKB/Swiss-Prot:P80864" /translation="MAEITFKGGPVTLVGQEVKVGDQAPDFTVLTNSLEEKSLADMKG KVTIISVIPSIDTGVCDAQTRRFNEEAAKLGDVNVYTISADLPFAQARWCGANGIDKV ETLSDHRDMSFGEAFGVYIKELRLLARSVFVLDENGKVVYAEYVSEATNHPNYEKPIE AAKALVK*" /label="tpx CDS" gene complement(2524110..2524613) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /label="tpx gene" downshifts complement(2524116) /Source="Nicolas_upshifts" /id="D1509" /incds=0 /nref=53 /ntot=241 /MaxReadThrough="6.94509" /MaxDrop="4.3179" /score="9.29337297" /energy="-10.1" /TU="U2279" /idTUdmin="U2280" /TUdmin=548 /isTUend="FALSE" /label="downshifts" promotor_no_box 2524330..2524430 /Source="Nicolas_upshift_promotors" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2524390 /Source="Nicolas_upshifts" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2524609 /Source="Nicolas_upshifts" /id="D1510" /incds=0 /nref=86 /ntot=184 /MaxReadThrough="2.23568" /MaxDrop="5.49495" /score="20.1242958" /energy="-12.7" /TU="NA" /idTUdmin="U2278" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2524636..2524655) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2524652) /Source="Nicolas_upshifts" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2524669..2524676) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2524723..2525178) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /experiment="publication(s) with functional evidences, PMID:23921501, 25790435, 27881417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23921501, 25790435, 27881417; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination-associated protein" /protein_id="NP_390828.1" /db_xref="EnsemblGenomes-Gn:BSU29500" /db_xref="EnsemblGenomes-Tr:CAB14928" /db_xref="GOA:O34806" /db_xref="InterPro:IPR014229" /db_xref="SubtiList:BG13849" /db_xref="UniProtKB/Swiss-Prot:O34806" /translation="MADHPIQGLMKTAMENLKEMIDVNTIIGDPVETPDGSVILTVSK VGFGFAAGGSEFGGKPAEKKSEDDETREQKLPFGGGSGGGVSITPIAFLIVGSTGIRM LHLDENTHLIEKILDAAPQTLERIQQMFKKNNKNQSQGQNQNQMNNMNY*" /label="gerW CDS" gene complement(2524723..2525178) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /label="gerW gene" downshifts complement(2524751) /Source="Nicolas_upshifts" /id="D1511" /incds=0 /nref=38 /ntot=91 /MaxReadThrough="3.69502" /MaxDrop="5.65648" /score="26.1939476" /energy="-12.7" /TU="U2280" /idTUdmin="U2280" /TUdmin="-87" /isTUend="FALSE" /label="downshifts" CDS complement(2525192..2525872) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390829.1" /db_xref="EnsemblGenomes-Gn:BSU29510" /db_xref="EnsemblGenomes-Tr:CAB14929" /db_xref="InterPro:IPR021338" /db_xref="SubtiList:BG13848" /db_xref="UniProtKB/Swiss-Prot:O34917" /translation="MVYVLTAILILIGIVLLLRMKIHVALEYLHADDNDKLTLKITAL FGLIRIKKTIPAIKVNKEDGTVDIKQKTESKMKKSSGKKKITQNDVQQSINKIEMLLH QVTRLRKISASFLAHLHITKLEWVTVIGIQDAAVTGVLTGAVWGVKGGIAAMLYDHLD FVNKPVYEVIPSFQVPVSKTHFQCIFFFRFGHAMLAAFKFVKYGRELSVLKKNPSARM TSKNDSSV*" /label="ytfI CDS" gene complement(2525192..2525872) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /label="ytfI gene" upshifts complement(2525284) /Source="Nicolas_upshifts" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="upshifts" promotor_-10 complement(2525291..2525302) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-10" promotor_-35 complement(2525317..2525323) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-35" downshifts complement(2525610) /Source="Nicolas_upshifts" /id="D1512" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.64036" /MaxDrop="2.98792" /score="28.0381876" /energy="-11.8" /TU="U2281" /idTUdmin="U2281" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2525885..2525903) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-10" upshifts complement(2525899) /Source="Nicolas_upshifts" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="upshifts" promotor_-35 complement(2525918..2525923) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-35" CDS complement(2525947..2526441) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390830.1" /db_xref="EnsemblGenomes-Gn:BSU29520" /db_xref="EnsemblGenomes-Tr:CAB14930" /db_xref="GOA:O34424" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG13840" /db_xref="UniProtKB/Swiss-Prot:O34424" /translation="MDATYEELERNDIKGPQEAELLTHAYAGFWVRFWAFLLDWLVIW GLNHLLVSPLFTVLDLPKTSGMFTFSAYSVTTLIVYLAYFALMTKYFRQTLGKMVFGL KVVSVKQDSKLTWSTVIFREVVGRYIDKIWILYIVVAFSPTKQGIHDYIADTTVVHEK LYRK*" /label="yteJ CDS" gene complement(2525947..2526441) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /label="yteJ gene" downshifts complement(2525962) /Source="Nicolas_upshifts" /id="D1513" /incds=0 /nref=240 /ntot=258 /MaxReadThrough="1.43721" /MaxDrop="6.8315" /score="28.0381876" /energy="-11.8" /TU="NA" /idTUdmin="U2282" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2526454..2527461) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9987136, 10455123, 16484219, 22472423, 23155385, 24228759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 10455123, 16484219, 22472423, 23155385, 24228759; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="signal peptide peptidase" /protein_id="NP_390831.1" /db_xref="EnsemblGenomes-Gn:BSU29530" /db_xref="EnsemblGenomes-Tr:CAB14931" /db_xref="GOA:O34525" /db_xref="InterPro:IPR002142" /db_xref="InterPro:IPR004635" /db_xref="InterPro:IPR029045" /db_xref="PDB:3RST" /db_xref="PDB:4KWB" /db_xref="SubtiList:BG13839" /db_xref="UniProtKB/Swiss-Prot:O34525" /translation="MNAKRWIALVIALGIFGVSIIVSISMSFFESVKGAQTDLTSLTD ESQEKTLENGSPSSKIAVLEVSGTIQDNGDSSSLLGADGYNHRTFLKNLERAKDDKTV KGIVLKVNSPGGGVYESAEIHKKLEEIKKETKKPIYVSMGSMAASGGYYISTAADKIF ATPETLTGSLGVIMESVNYSKLADKLGISFETIKSGAHKDIMSPSREMTKEEKNIMQS MVDNSYEGFVDVISKGRGMPKAEVKKIADGRVYDGRQAKKLNLVDELGFYDDTITAMK KDHKDLKNASVISYEESFGLGSLFSMGANKMFKSEIDFLNMREILSQSGSPRMMYLYA K*" /label="sppA CDS" gene complement(2526454..2527461) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /label="sppA gene" promotor_-10 complement(2527485..2527500) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2527502) /Source="Nicolas_upshifts" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2527504..2527583) /Source="Nicolas_S_feature" /locus_tag="new_3021090_3021169_c" /HighExp="LBGexp, Oxctl, LBGtran, dia0, H2O2, dia15, G180, G150, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1121" promotor_-35 complement(2527512..2527521) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2527561..2527580 /Source="Nicolas_upshift_promotors" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2527571 /Source="Nicolas_upshifts" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2527576..2527595) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2527580..2527646 /Source="Nicolas_S_feature" /locus_tag="new_3021166_3021232" /HighExp="M0t90, Sw, M9-stat, BC, M40t90, T4.0H, T2.30H, S1, T3.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1122" upshifts complement(2527583) /Source="Nicolas_upshifts" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2527611..2527615) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2527647..2528450 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /EC_number="2.7.1.23" /function="16.7: Manage energy" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897004, 16233726, 16511117, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase" /protein_id="NP_390832.1" /db_xref="EnsemblGenomes-Gn:BSU29540" /db_xref="EnsemblGenomes-Tr:CAB14932" /db_xref="GOA:O34934" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13837" /db_xref="UniProtKB/Swiss-Prot:O34934" /translation="MTDQRRNVYFFHKQDQETNEQARSLTQLAEEHGFTVVNQHSDAN IIASIGGDGTFLQAVRKTNFRDDCLYVGITKKGKAHLYCDFHSDEREKMVDAMTFEQI EVRKYPLIEVTVDQASPFHCLNEVSIRSSIIKTFVMDVLIDDLHFETFRGDGMIISTP TGSTAYNKSVAGAVVDPLLPCMQVSELASLNNNTYRTLGSPFVLSSDRKLTLRVVQDG NEHPIIGLDNEALSTRNVKTIEIKLSNKKIKTVKLKDNSFWEKVKRTFL*" /label="ppnKB CDS" gene 2527647..2528450 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /label="ppnKB gene" downshifts 2528380 /Source="Nicolas_upshifts" /id="D1514" /incds=1 /nref=46 /ntot=222 /MaxReadThrough="5.39036" /MaxDrop="3.90238" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-124" /isTUend="FALSE" /label="downshifts" downshifts 2528438 /Source="Nicolas_upshifts" /id="D1515" /incds=0 /nref=6 /ntot=54 /MaxReadThrough="3.14676" /MaxDrop="4.64552" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2528482..2530071) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19433221, 20386924, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-substituted formamide deformylase, dihydropyrimidinase or isoaspartyl peptidase" /protein_id="NP_390833.1" /db_xref="EnsemblGenomes-Gn:BSU29550" /db_xref="EnsemblGenomes-Tr:CAB14933" /db_xref="GOA:O34355" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR013108" /db_xref="InterPro:IPR032466" /db_xref="InterPro:IPR033932" /db_xref="SubtiList:BG13835" /db_xref="UniProtKB/Swiss-Prot:O34355" /translation="MKAIWHGGFIYTMLEEGDRTEAVYVEDGVIKGTGSYERLKEKYG SPETEEISLNGAVMFPGFVDSHLHLIGHGEKQLQLDLSALTSKDSILQAAKERERQLP KNDWLIGEGWNENQFETPDYLTKHDLDRLFPDRPVLLKRICRHAIAVNSAALQAAGIS RNTPDPDGGVIVKDANGEPTGLLFDKAQDLILKAVPPVSQHYVDEALTAAIKDCWTKG LTGGHSEDLSYYGDVSVPMKAYEKAAAGGKYPFRCHLLVHHEAVDRWEQLEKLSGPYV EFGAMKIFADGALGGRTALLKEPYQDDPSTNGVQVHDDETLGRLIRKAREKGMEVAVH AIGDLAFEKVLNAIEKHPPKNGRHDRLIHAQVLDNELIERAARMPIALDLQPHFVASD FPWVIDRLGKDRMKTAFAWKTLISKGILCAGGSDAPIEPVDPLLGIQSAVLRKSSHEQ NGPSYNESECLPVYEAIKLYTEGSAGIIYKEKSRGKIAEGYDADFTVLSGDPFAIDPA QLHLLEIKKTVINGQIVYEKS*" /label="ytcJ CDS" gene complement(2528482..2530071) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /label="ytcJ gene" downshifts complement(2528491) /Source="Nicolas_upshifts" /id="D1516" /incds=0 /nref=149 /ntot=255 /MaxReadThrough="2.61299" /MaxDrop="5.92403" /score="32.0110789" /energy="-13.8" /TU="NA" /idTUdmin="U2285" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2530091..2531680) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /EC_number="6.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-coenzyme A synthetase" /protein_id="NP_390834.2" /db_xref="EnsemblGenomes-Gn:BSU29560" /db_xref="EnsemblGenomes-Tr:CAB14934" /db_xref="GOA:C0SPB0" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13834" /db_xref="UniProtKB/Swiss-Prot:C0SPB0" /translation="MLKREDLIAPVQYNLVNEMEKFSAAGQKTALLWEDESGKQESWS YEKLMEETNKIGAALADLGFKKGDKLIVMVPRVLEAYAVYLAILKSGMVVIPCSEMLR AKDLEYRIEHAEVKGAIVYSEFIGAFRDVSTADKLITLSIGENDAGWKNLLSIEADGS QFKTADTTRDDMAFLSYTSGTTGQPKGVVHTHGWAFAHLKTSAGAWLDISEKDIVWAT AAPGWQKWVWSPFLAVLGSGATGFVYHGRFKAEKYLELLNRYKINVFCCTPTEYRLMA KVEGLKRFDLSALHSAVSAGEPLNREVIDVFQKHFGIKVRDGYGQTESTLLVGVLKDT PIKPGSMGKPTPGNQVEIINEDGEICKPGEVGDIAVHLSTPALFKEYFKDPERMKTQI RGDYFLTGDRARKDEEGYFWFESRNDDIIISSGYTIGPFEVEDALVKHPEVKECAVVA SPDEIRGSIVKAYVVLQNHEKRSDELVKMLQNHVKTITAPYKYPREIEFVESLPKTAS AKIRRVELRKREEQLKANKKA*" /label="ytcI CDS" gene complement(2530091..2531680) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /label="ytcI gene" promotor_-10 complement(2531726..2531743) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2531731) /Source="Nicolas_upshifts" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2531759..2531765) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2531858) /Source="Nicolas_upshifts" /id="D1517" /incds=0 /nref=242 /ntot=266 /MaxReadThrough="2.32229" /MaxDrop="9.17935" /score="30.5720337" /energy="-13.3" /TU="NA" /idTUdmin="U2287" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2531859..2532068) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:2456528, 2468649, 3009398, 16707666" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2456528, 2468649, 3009398, 16707666; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha-type SASP)" /protein_id="NP_390835.1" /db_xref="EnsemblGenomes-Gn:BSU29570" /db_xref="EnsemblGenomes-Tr:CAB14935" /db_xref="GOA:P04831" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10786" /db_xref="UniProtKB/Swiss-Prot:P04831" /translation="MANNNSGNSNNLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRA NGSVGGEITKRLVSFAQQNMGGGQF*" /label="sspA CDS" gene complement(2531859..2532068) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /label="sspA gene" promotor_-35 2532064..2532068 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2532068 /Source="Nicolas_upshifts" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2532077..2532091 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2532089..2532100) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2532100) /Source="Nicolas_upshifts" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2532115..2532121) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2532162..2533367) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /EC_number="2.8.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14757766, 16343540, 22773787, 24705700, 28287455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14757766, 16343540, 22773787, 24705700, 28287455; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="persulfide ATP pyrophosphatase involved in tRNA modification" /protein_id="NP_390836.2" /db_xref="EnsemblGenomes-Gn:BSU29580" /db_xref="EnsemblGenomes-Tr:CAB14936" /db_xref="GOA:O34595" /db_xref="InterPro:IPR003720" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020536" /db_xref="SubtiList:BG13827" /db_xref="UniProtKB/Swiss-Prot:O34595" /translation="MNYDHILIRFGEISTKGKNRKSFIERLKQNIRLVLKDYPNLKYF SNRDRMTITLNGEDPEALFPHLKQVFGIQSFSLAIKCDSRLDDIKATALKAIKDQYKP GDTFKVATKRAYKQFELDTNQMNAEIGGHILRNTEGLTVDVRNPDIPLRIEIREEATF LTIRDEKGAGGLPVGSAGKAMLMLSGGFDSPVAGFYAMKRGLSVEAVHFFSPPYTSER AKQKVMDLAKCLSRFGGSMTLHIVPFTKTQELIQKQIPENYTMTATRRLMLQIADRIR EKRNGLAIITGESLGQVASQTLESMYAINAVTSTPILRPLIAMDKTEIIEKSREIGTY ETSIQPFEDCCTIFTPPSPKTRPKKEKIEHFESFVDFEPYIQEAVDNIETMTLYSEQE ANDKFAELF*" /label="trmG CDS" gene complement(2532162..2533367) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /label="trmG gene" CDS complement(2533371..2534516) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_390837.1" /db_xref="EnsemblGenomes-Gn:BSU29590" /db_xref="EnsemblGenomes-Tr:CAB14937" /db_xref="GOA:O34874" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="SubtiList:BG12632" /db_xref="UniProtKB/Swiss-Prot:O34874" /translation="MIYLDNSSTTKPYDEVLNVYEQTSSRYFGNPSSLHRYGAETEQL LQAAKNQIKRSLGLKKYDIVFTSGATEANNAALKGAALSKIKTGKHIIATSIEHPSVT ESLEQLKELFGFDITYLSVNEDGFVSIEDLKAAIRPDTVLVSMMHVNNEVGSVQPIEA AGEVLKEHSNILFHVDYVQGIYKVPLAIEKAGIDLCSISGHKFHGLKGTGALIVKEGT RLIPLITGGSQQKGIRAGTEHTAGAVSLAKAINLASADFDTRLDTMTAVKELFMNRLS EIEGVVINTPQMNSAPHIINFSVPGIKAEVLLHMLEEQDIFVSTTSACSAKEHKPSKV LLEMGKGEQIAGSSIRISLNYSQTSDVAEPFMNALRPGIKKLREMMR*" /label="iscSB CDS" gene complement(2533371..2534516) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /label="iscSB gene" S_feature complement(2534517..2535660) /Source="Nicolas_S_feature" /locus_tag="new_3028103_3029246_c" /HighExp="Diami, dia15, dia5, H2O2, G135, G180, G150, C30, Paraq, LBGstat" /AntisenseName="braB" /AntisenseCor="0.41502288403214899" /AntisenseRegPval="-11.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1123" promotor_-35 2534603..2534610 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2534621..2534710 /Source="Nicolas_S_feature" /locus_tag="new_3028207_3028296" /HighExp="LPh, HPh, BMM, dia0, Heat, G180, Cold, LBGexp, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1124" upshifts 2534621 /Source="Nicolas_upshifts" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2534623..2534642 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2534711..2536048 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11528000, 15849754, 16850406, 26473603" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11528000, 15849754, 16850406, 26473603; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid-Na+ symporter" /protein_id="NP_390838.1" /db_xref="EnsemblGenomes-Gn:BSU29600" /db_xref="EnsemblGenomes-Tr:CAB14938" /db_xref="GOA:O34545" /db_xref="InterPro:IPR004685" /db_xref="SubtiList:BG12573" /db_xref="UniProtKB/Swiss-Prot:O34545" /translation="MKHSLPVKDTIIIGFMLFALFFGAGNMIYPPELGQAAGHNVWKA IGGFLLTGVGLPLLGIIAIALTGKDAKGLADKAHPVFGTIFTVVLYLSIGPLFAIPRT GTVSYEIGAVPFLTGVPERLSLLIFTLIFFGVTYYLALNPSKVVDRVGKILTPIKFTI ILIIVLKAIFTPMGGLGAVTEAYKGTPVFKGFLEGYKTMDALASIVFGVVVVNAVKSK GVTQSKALAAACIKAGVIAALGLTFIYVSLAYLGATSTNAIGPVGEGAKILSASSHYL FGSLGNIVLGAAITVACLTTSIGLVTSCGQYFSKLIPALSYKIVVTIVTLFSLIIANF GLAQIIAFSVPILSAIYPLAIVIIVLSFIDKIFKERREVYIACLIGTGLFSILDGIKA AGFSLGSLDVFLNANLPLYSLGIGWVLPGIVGAVIGYVLTLFIGPSKQLNEIS*" /label="braB CDS" gene 2534711..2536048 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /label="braB gene" promotor_-10 complement(2535646..2535665) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2535660) /Source="Nicolas_upshifts" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2535680..2535687) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2536024 /Source="Nicolas_upshifts" /id="D1518" /incds=0 /nref=69 /ntot=174 /MaxReadThrough="1.86149" /MaxDrop="6.26921" /score="14.5905051" /energy="-15.2" /TU="U2288" /idTUdmin="U2288" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2536143..2537831) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of FtsZ ring formation" /protein_id="NP_390839.1" /db_xref="EnsemblGenomes-Gn:BSU29610" /db_xref="EnsemblGenomes-Tr:CAB14939" /db_xref="GOA:O34894" /db_xref="InterPro:IPR010379" /db_xref="PDB:4UXV" /db_xref="SubtiList:BG13934" /db_xref="UniProtKB/Swiss-Prot:O34894" /translation="MEFVIGLLIVLLALFAAGYFFRKKIYAEIDRLESWKIEILNRSI VEEMSKIKHLKMTGQTEEFFEKWREEWDEIVTAHMPKVEELLYDAEENADKYRFKKAN QVLVHIDDLLTAAESSIEKILREISDLVTSEEKSREEIEQVRERYSKSRKNLLAYSHL YGELYDSLEKDLDEIWSGIKQFEEETEGGNYITARKVLLEQDRNLERLQSYIDDVPKL LADCKQTVPGQIAKLKDGYGEMKEKGYKLEHIQLDKELENLSNQLKRAEHVLMTELDI DEASAILQLIDENIQSVYQQLEGEVEAGQSVLSKMPELIIAYDKLKEEKEHTKAETEL VKESYRLTAGELGKQQAFEKRLDEIGKLLSSVKDKLDAEHVAYSLLVEEVASIEKQIE EVKKEHAEYRENLQALRKEELQARETLSNLKKTISETARLLKTSNIPGIPSHIQEMLE NAHHHIQETVNQLNELPLNMEEAGAHLKQAEDIVNRASRESEELVEQVILIEKIIQFG NRFRSQNHILSEQLKEAERRFYAFDYDDSYEIAAAAVEKAAPGAVEKIKADISA*" /label="ezrA CDS" gene complement(2536143..2537831) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /label="ezrA gene" downshifts complement(2536144) /Source="Nicolas_upshifts" /id="D1519" /incds=0 /nref=224 /ntot=257 /MaxReadThrough="3.34218" /MaxDrop="5.3305" /score="9.25784495" /energy="-8.6" /TU="U2290" /idTUdmin="U2290" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2537832..2537937) /Source="Nicolas_S_feature" /locus_tag="new_3031418_3031523_c" /HighExp="C90, Lbtran, BMM, LBGtran, MG 150, S1, Lbexp, dia0, LBGexp, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1125" promotor_-35 2537914..2537922 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2537925..2537944) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2537933..2537952 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2537937) /Source="Nicolas_upshifts" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="upshifts" upshifts 2537937 /Source="Nicolas_upshifts" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" S_feature 2537938..2538027 /Source="Nicolas_S_feature" /locus_tag="new_3031524_3031613" /HighExp="HiOs, C90, dia5, T-5.40H, S1, T-3.40H, GM-0.1, GM 15, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1126" S_feature complement(2537939..2538498) /Source="Nicolas_S_feature" /locus_tag="new_3031525_3032084_c" /HighExp="Etha, Salt, Cold, G135, Lbstat, G180, G150, H2O2, Heat, Paraq" /AntisenseName="hisJ" /AntisenseCor="0.37018688255337001" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1127" promotor_-35 complement(2537960..2537962) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2538028..2538834 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /EC_number="3.1.3.15" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10322033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol phosphate phosphatase" /protein_id="NP_390840.1" /db_xref="EnsemblGenomes-Gn:BSU29620" /db_xref="EnsemblGenomes-Tr:CAB14940" /db_xref="GOA:O34411" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010140" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG13931" /db_xref="UniProtKB/Swiss-Prot:O34411" /translation="MQKRDGHIHTPFCPHGSNDTLRQYAEEALKKGFESITFTEHAPL PPSFTDPTPLKDSAMAQASLERYIHEISGLKKEYRGQLSIRTGLEVDYIAEFEDEITL FLDTYGPYLDDSILSVHFLRTDSSYLCLDYDEHTFKELISACGSIEAVYEQYYRSIYS SIVASLGVYKPKRVGHITLVQKFIKLFPYSMSEHIRGLVSLCLNAIEENGMELDFNTS GLRKTYAGGIYIEDWMLNEAKQKKIPLVFGSDAHQAGDVGYAYEAFLERC*" /label="hisK CDS" gene 2538028..2538834 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /label="hisK gene" promotor_-10 complement(2538502..2538521) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2538515) /Source="Nicolas_upshifts" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2538533..2538540) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2538784..2538830) /Source="Nicolas_S_feature" /locus_tag="new_3032370_3032416_c" /HighExp="M9-stat, T5.0H, LoTm, T4.0H, S2, BC, T3.30H, S4, T3.0H, B60" /AntisenseName="hisJ" /AntisenseCor="-0.46006853678527698" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1128" downshifts complement(2538806) /Source="Nicolas_upshifts" /id="D1520" /incds=0 /nref=51 /ntot=97 /MaxReadThrough="1.55523" /MaxDrop="6.84653" /score="-4.34170655" /energy="-10.5" /TU="NA" /idTUdmin="U2296" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2538831..2539454) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11988534, 22730127, 26360512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 22730127, 26360512; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of FtsZ defining the chromosome regioncaptured in the forespore" /protein_id="NP_390841.1" /db_xref="EnsemblGenomes-Gn:BSU29630" /db_xref="EnsemblGenomes-Tr:CAB14941" /db_xref="GOA:O34970" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG13927" /db_xref="UniProtKB/Swiss-Prot:O34970" /translation="MKVSTKDKIIESAVMLFNQKGFSGTSVREIAKSADVNVAHISYY FKGKGGLMEHLVSEFYEGYSKTLETAASNISTQSTQEQLLQLVFDILSYQHNHRQLTR FVYREVTIDSTLIREIMSTYLMKEKYIFQLIIEEGEKQREYLTLPLPHFILQLKSLLM MPYLQPQYISEVLYMQPHEPYFYKMYFEEIKIWIRSVFRTGDVALTN*" /label="refZ CDS" gene complement(2538831..2539454) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /label="refZ gene" S_feature 2538835..2539177 /Source="Nicolas_S_feature" /locus_tag="new_3032421_3032763" /HighExp="C90, HiOs, Sw, dia5, GM-0.1, S1, MG 5, UNK1, MG 60, MG t5" /AntisenseName="yttP" /AntisenseCor="-0.79169109805002003" /AntisenseRegPval="-58.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1129" promotor_-35 2539155..2539162 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2539177..2539196 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2539179..2539322 /Source="Nicolas_S_feature" /locus_tag="new_3032765_3032908" /HighExp="Diami, dia15, dia5, H2O2, C90, Paraq, Salt, Etha, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.81457903975257295" /AntisenseRegPval="-64.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1130" upshifts 2539179 /Source="Nicolas_upshifts" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2539294..2539298 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2539314..2539333 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2539324..2539454 /Source="Nicolas_S_feature" /locus_tag="new_3032910_3033040" /HighExp="Diami, dia15, dia5, H2O2, Paraq, C90, HPh, LBGexp, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.82273476313537297" /AntisenseRegPval="-66.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1131" upshifts 2539324 /Source="Nicolas_upshifts" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" S_feature 2539456..2539580 /Source="Nicolas_S_feature" /locus_tag="new_3033042_3033166" /HighExp="Diami, dia5, dia15, H2O2, C90, BC, HiOs, Paraq, Sw, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.598, 0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1132" upshifts 2539456 /Source="Nicolas_upshifts" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2539470..2539488) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2539472..2539491 /Source="Nicolas_upshift_promotors" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2539488) /Source="Nicolas_upshifts" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2539499..2539507) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2539581..2540072 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /EC_number="1.8.4.14" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17535911, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="free methionine-(R)-sulfoxide reductase" /protein_id="NP_390842.2" /db_xref="EnsemblGenomes-Gn:BSU29640" /db_xref="EnsemblGenomes-Tr:CAB14942" /db_xref="InterPro:IPR000614" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG13923" /db_xref="UniProtKB/Swiss-Prot:O34553" /translation="MFHVEKQSGDKEKDYQLLLKQLEAMTEDETDQIANYANASALLY HSLPEVNWAGFYFAKEEDGQLVLGPFQGLPACVRIPFGRGVCGTAYANGKVERIEDVN AFPGHIACDAASQSEIVLPIRVDGKIVGVLDIDSPVKNRFDEIDEKYLTQFAETLEKA LAQ*" /label="msrC CDS" gene 2539581..2540072 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /label="msrC gene" downshifts 2540051 /Source="Nicolas_upshifts" /id="D1521" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="3.66093" /MaxDrop="6.50628" /score="34.0123402" /energy="-11.9" /TU="U2291,U2293,U2294" /idTUdmin="U2295" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2540110..2541849) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /EC_number="2.7.7.65" /function="16.12: Sense" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_390843.1" /db_xref="EnsemblGenomes-Gn:BSU29650" /db_xref="EnsemblGenomes-Tr:CAB14943" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG13918" /db_xref="UniProtKB/Swiss-Prot:O34325" /translation="MVEQTKDQLSAFHYHMLDFLLTKSEKVTFTDSFIWLTSAIQTYF STLCVSLTPSPSDFVTKLADGEARFSASKINASCYLIEDGSGRRFHLACRQDEEIPEG LPDVVASFLNQSMKQERLYNKTIYQKKIYKMTELFHSLLDQTDVLKQLLESLTSTFSL FEFSLFISHDQDQCLGIPAKELYMEGEKSDSFALKVYLSGDILRKNESVAYIPIKGQQ GTYGVLKAEGTGDSFLTDACLDEMSLLANAAGKAFENAQLYEQSKASIANLELINETS RRLNQRLTLTDTMNDLAVRMAESFQAEEVGFFHIDHFENLTLLPGSTAFFKEAKPSDF YNELKEKLYEGEKGVFIGNGQSVFGKAGYGSLMAAPMIQNDRLLGFAVLLKQELYAFT FEMYKLFQALIHHATLAVTNSMLRDRLEHLVKTDQLTELYSRAYLDEKIQYSMKIHQK GVFILVDIDNFKNVNDTYGHQTGDEILIQVASVIKSNIRKHDVGARWGGEELAIYLPN VPVAVGKRITERLVYAVRKNTKPEVTISCGISCWTTETKKSLKELVHEADEALYSAKR SGKNRLMIHDSIK*" /label="dgcP CDS" gene complement(2540110..2541849) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /label="dgcP gene" downshifts complement(2540128) /Source="Nicolas_upshifts" /id="D1522" /incds=0 /nref=23 /ntot=178 /MaxReadThrough="3.68958" /MaxDrop="4.52201" /score="-0.637788006" /energy="-11.9" /TU="U2298" /idTUdmin="U2298" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" promotor_-35 2541323..2541330 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-35" promotor_-10 2541344..2541362 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-10" upshifts 2541347 /Source="Nicolas_upshifts" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="upshifts" S_feature 2541349..2541944 /Source="Nicolas_S_feature" /locus_tag="new_3034935_3035530" /HighExp="Cold, LBGstat, C30, Lbstat, GM 25, GM 10, GM 120, GM-0.1, GM 5, GM-0.2" /AntisenseName="ytrP" /AntisenseCor="-0.113221814489707" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1133" misc_feature complement(2541879..2541898) /Source="Nicolas_upshift_promotors" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2541887) /Source="Nicolas_upshifts" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2541889..2542722) /Source="Nicolas_S_feature" /locus_tag="new_3035475_3036308_c" /HighExp="Etha, S7, Gly, S8, M9-stat, Sw, G135, S6, BC, C30" /AntisenseName="rpsD" /AntisenseCor="-0.48019282175486899" /AntisenseRegPval="-16.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1134" promotor_-35 2541925..2541932 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2541946..2542143 /Source="Nicolas_S_feature" /locus_tag="new_3035532_3035729" /HighExp="UNK1, Cold, HPh, C30, aero, LPhT, MG 25, Oxctl, Heat, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.139124" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1135" promotor_-10 2541946..2541965 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2541946 /Source="Nicolas_upshifts" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 2542003..2542135 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /product="ribosomal protein S4 leader mRNA sequence" /experiment="publication(s) with functional evidences, PMID:23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23611891" /label="ldsD RNA" gene 2542003..2542135 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /label="ldsD gene" CDS 2542144..2542746 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1400226, 1699930, 1906866, 12682299, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400226, 1699930, 1906866, 12682299, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S4 (BS4)" /protein_id="NP_390844.1" /db_xref="EnsemblGenomes-Gn:BSU29660" /db_xref="EnsemblGenomes-Tr:CAB14944" /db_xref="GOA:P21466" /db_xref="InterPro:IPR001912" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR005709" /db_xref="InterPro:IPR018079" /db_xref="InterPro:IPR022801" /db_xref="InterPro:IPR036986" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10372" /db_xref="UniProtKB/Swiss-Prot:P21466" /translation="MARYTGPSWKLSRRLGISLSGTGKELEKRPYAPGPHGPGQRKKL SEYGLQLQEKQKLRHMYGVNERQFRTLFDKAGKLAGKHGENFMILLDSRLDNVVYKLG LARTRRQARQLVNHGHILVDGSRVDIPSYLVKPGQTIGVREKSRNLSIIKESVEVNNF VPEYLTFDAEKLEGTFTRLPERSELAPEINEALIVEFYSR*" /label="rpsD CDS" gene 2542144..2542746 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /label="rpsD gene" downshifts 2542669 /Source="Nicolas_upshifts" /id="D1523" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="8.1141" /MaxDrop="2.9392" /score="31.6842" /energy="-13.6" /TU="U2297,U2299" /idTUdmin="U2297" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" S_feature complement(2542724..2542943) /Source="Nicolas_S_feature" /locus_tag="new_3036310_3036529_c" /HighExp="S5, Etha, S8, S6, S7, S4, BT, S3, M9-stat, B36" /AntisenseName="rpsD" /AntisenseCor="-0.59018291599064199" /AntisenseRegPval="-25.9" /CDS_PredictionProba="0.99997899999999995" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1136" downshifts 2542732 /Source="Nicolas_upshifts" /id="D1524" /incds=0 /nref=135 /ntot=252 /MaxReadThrough="5.6866" /MaxDrop="6.10502" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=19 /isTUend="TRUE" /label="downshifts" downshifts complement(2542767) /Source="Nicolas_upshifts" /id="D1525" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="4.84346" /MaxDrop="3.28594" /score="-4.07107651" /energy="-10.8" /TU="U2300" /idTUdmin="U2301" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 2542779 /Source="Nicolas_upshifts" /id="D1526" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="5.7799" /MaxDrop="4.26349" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature 2542824..2542997 /Source="Nicolas_S_feature" /locus_tag="new_3036410_3036583" /HighExp="LBGtran, LoTm, C30, Cold, LBGexp, B60, dia15, B36, H2O2, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig=1 /label="S1137" promotor_-10 complement(2542939..2542957) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2542951) /Source="Nicolas_upshifts" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="upshifts" downshifts 2542955 /Source="Nicolas_upshifts" /id="D1527" /incds=0 /nref=7 /ntot=151 /MaxReadThrough="1.39547" /MaxDrop="6.12149" /score="26.4940291" /energy="-16.4" /TU="NA" /idTUdmin="U2299" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2542972..2542978) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2543017..2544285) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /EC_number="6.1.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12547201, 15879350, 1735721, 9098057" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12547201, 15879350, 1735721, 9098057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_390845.1" /db_xref="EnsemblGenomes-Gn:BSU29670" /db_xref="EnsemblGenomes-Tr:CAB14945" /db_xref="GOA:P22326" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024107" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10371" /db_xref="UniProtKB/Swiss-Prot:P22326" /translation="MTNLLEDLSFRGLIQQMTDEEGLNKQLNEEKIRLYSGFDPTADS LHIGHLLPILTLRRFQLAGHHPIALVGGATGLIGDPSGKKAERTLNTADIVSEWSQKI KNQLSRFLDFEAAENPAVIANNFDWIGKMNVIDFLRDVGKNFGINYMLAKDTVSSRIE SGISYTEFSYMILQSYDFLNLYRDKNCKLQIGGSDQWGNITAGLELIRKSEEEGAKAF GLTIPLVTKADGTKFGKTEGGAIWLDKEKTSPYEFYQFWINTDDRDVVKYLKYFTFLS KEEIEAYAEKTETAPEKREAQKRLAEEVTSLVHGREALEQAINISQALFSGNIKELSA QDVKVGFKDVPSMEVDSTQELSLVDVLVQSKLSPSKRQAREDIQNGAVYINGERQTEI NYTLSGEDRIENQFTVLRRGKKKYFLVTYK*" /label="tyrS CDS" gene complement(2543017..2544285) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /label="tyrS gene" downshifts complement(2543043) /Source="Nicolas_upshifts" /id="D1528" /incds=0 /nref=110 /ntot=357 /MaxReadThrough="2.2673" /MaxDrop="6.847" /score="22.5238672" /energy="-16.4" /TU="NA" /idTUdmin="U2301" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" misc_RNA complement(2544309..2544582) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /product="T-Box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 10943892, 1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 10943892, 1317842, 9098041, 12165569, 12547201; Product type n : RNA" /function="16.3: Control" /label="tboY RNA" gene complement(2544309..2544582) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /label="tboY gene" S_feature complement(2544330..2544473) /Source="Nicolas_S_feature" /locus_tag="new_3037916_3038059_c" /HighExp="B60, Sw, B36, BC, M9-stat, T1.30H, S4, T4.0H, T2.30H, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40126600000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1138" downshifts complement(2544373) /Source="Nicolas_upshifts" /id="D1529" /incds=0 /nref=58 /ntot=127 /MaxReadThrough="6.75235" /MaxDrop="6.49727" /score="45.7279775" /energy="-17.7" /TU="U2301,U2303" /idTUdmin="U2301" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2544580..2544599) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2544592) /Source="Nicolas_upshifts" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2544612..2544619) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2544627..2546345) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /EC_number="6.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7934817, 10986270, 11255012, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10986270, 11255012, 16855235, 18487328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA synthetase" /protein_id="NP_390846.1" /db_xref="EnsemblGenomes-Gn:BSU29680" /db_xref="EnsemblGenomes-Tr:CAB14946" /db_xref="GOA:P39062" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG10370" /db_xref="UniProtKB/Swiss-Prot:P39062" /translation="MNLKALPAIEGDHNLKNYEETYRHFDWAEAEKHFSWHETGKLNA AYEAIDRHAESFRKNKVALYYKDAKRDEKYTFKEMKEESNRAGNVLRRYGNVEKGDRV FIFMPRSPELYFIMLGAIKIGAIAGPLFEAFMEGAVKDRLENSEAKVVVTTPELLERI PVDKLPHLQHVFVVGGEAESGTNIINYDEAAKQESTRLDIEWMDKKDGFLLHYTSGST GTPKGVLHVHEAMIQQYQTGKWVLDLKEEDIYWCTADPGWVTGTVYGIFAPWLNGATN VIVGGRFSPESWYGTIEQLGVNVWYSAPTAFRMLMGAGDEMAAKYDLTSLRHVLSVGE PLNPEVIRWGHKVFNKRIHDTWWMTETGSQLICNYPCMDIKPGSMGKPIPGVEAAIVD NQGNELPPYRMGNLAIKKGWPSMMHTIWNNPEKYESYFMPGGWYVSGDSAYMDEEGYF WFQGRVDDVIMTSGERVGPFEVESKLVEHPAIAEAGVIGKPDPVRGEIIKAFIALREG FEPSDKLKEEIRLFVKQGLAAHAAPREIEFKDKLPKTRSGKIMRRVLKAWELNLPAGD LSTMED*" /label="acsA CDS" gene complement(2544627..2546345) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /label="acsA gene" promotor_-35 2546359..2546366 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2546373..2546392) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2546381..2546400 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2546387 /Source="Nicolas_upshifts" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2546396) /Source="Nicolas_upshifts" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2546406..2546412) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2546429..2546436 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2546450..2546469 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2546453 /Source="Nicolas_upshifts" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="upshifts" CDS 2546506..2547138 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein acetyltransferase (acetylates AcsA)" /protein_id="NP_390847.1" /db_xref="EnsemblGenomes-Gn:BSU29690" /db_xref="EnsemblGenomes-Tr:CAB14947" /db_xref="GOA:P39065" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR024699" /db_xref="SubtiList:BG10369" /db_xref="UniProtKB/Swiss-Prot:P39065" /translation="MEHHKTYHSANIKTATGSLLIEGPVSPEDLAGYEFHKDLTAFRP PREQHEALVDIAGLPEGRIIIARDGRTIVGYVTYLYPDPLERWSEGNMEDLIELGAIE VAPDYRGCAVGKTLLTVSMMDEQMENYIVMTTEYYWHWDLKGMKKDVWEYRKIMEKMM NAGGLVWFATDEPEISSHPANCLMARIGKNVSQESIEQFDRLRFYHRYMY*" /label="acuA CDS" gene 2546506..2547138 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /label="acuA gene" promotor_-35 2546711..2546719 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2546733..2546752 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2546739 /Source="Nicolas_upshifts" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="upshifts" CDS 2547165..2547809 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type f : factor" /codon_start=1 /transl_table=11 /product="component of the acetyl-coenzyme A synthetase regulation pathway" /protein_id="NP_390848.1" /db_xref="EnsemblGenomes-Gn:BSU29700" /db_xref="EnsemblGenomes-Tr:CAB14948" /db_xref="GOA:P39066" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG10368" /db_xref="UniProtKB/Swiss-Prot:P39066" /translation="MIVEQIMKRDVITLTKTDTLETAICKLKEFHIRHLPVVDEERHV IGMITDRDMKQASPSIFEENKRSLFLTRSVDSIMKKDVVCAHPLDFVEEISAVFYEHG IGCLPVVHHQKLIGILTKTDLLRTFVKLTGADQPGSQIEIKVNDITKSLAEISSLCQD LQVKILSVLVYPHDDPGVKVLVFRVKTMNPLPFLQALQRNGHHVVWPSEQRDLL*" /label="acuB CDS" gene 2547165..2547809 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /label="acuB gene" CDS 2547806..2548969 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein deacetylase (regulates AcsA activity)" /protein_id="NP_390849.1" /db_xref="EnsemblGenomes-Gn:BSU29710" /db_xref="EnsemblGenomes-Tr:CAB14949" /db_xref="GOA:P39067" /db_xref="InterPro:IPR000286" /db_xref="InterPro:IPR003085" /db_xref="InterPro:IPR023696" /db_xref="InterPro:IPR023801" /db_xref="InterPro:IPR037138" /db_xref="SubtiList:BG10367" /db_xref="UniProtKB/Swiss-Prot:P39067" /translation="MRDSVFIYSPSYQTYMFHQEHPFNQQRVLLTYDLLKTINAFDDG DIVTPRLASEEELSLVHTDDYIQAVKLAGAGKLPAEEGESYGLGTEDTPVFAGMHEAA SLLVGGTLTAADWVMSGQALHAANLGGGLHHGFRGRASGFCIYNDSAVAIQYIQKKYS ARVLYIDTDAHHGDGVQFTFYDNPDVCTLSIHETGRYLFPGTGQIQEKGSGKGYGYSF NIPLDAFTEDDSFLEAYRTAASEVAAYFEPDVIISQNGADAHYYDPLTHLSATINIYE EIPRLAHTLAHQYCGGKWIAVGGGGYDIWRVVPRAWARIWLEMKGIDPGHEIPPEWIV KWQKQCPVALPSSWSDPADLYPPIPRKPEITEKNAQTVSKALYAIRSEQQRTK*" /label="acuC CDS" gene 2547806..2548969 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /label="acuC gene" downshifts 2548960 /Source="Nicolas_upshifts" /id="D1530" /incds=0 /nref=98 /ntot=231 /MaxReadThrough="0.530530000000001" /MaxDrop="6.5095" /score="10.9528437" /energy="-9.1" /TU="NA" /idTUdmin="U2304" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2548980..2549708) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator peptidoglycan binding subunit of flagellar rotation" /protein_id="NP_390850.1" /db_xref="EnsemblGenomes-Gn:BSU29720" /db_xref="EnsemblGenomes-Tr:CAB14950" /db_xref="GOA:P39064" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10366" /db_xref="UniProtKB/Swiss-Prot:P39064" /translation="MKLRRERFERRNGSGKNSQSSSSWMVTFTDLITLILVFFILLFS MSQIDLQKFKAAVDSIQKEGNGLQPDQTSIEKKNTSPSDTKKQEDQQDQLLKKVNTYI KDNHLKAQMTAKRDERGVVLVLQEAVLFDTGEAKVLKNAETLLHQIAVLLQTIPNDIQ VEGHTDSRNISTYRYPSNWELSAARASGVIQYFTSKEKLPSKRFIAVGYADTKPVKDN KTNEHMKENRRVEIVIKKSKTTSS*" /label="motS CDS" gene complement(2548980..2549708) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /label="motS gene" downshifts complement(2549016) /Source="Nicolas_upshifts" /id="D1531" /incds=0 /nref=37 /ntot=149 /MaxReadThrough="1.3853" /MaxDrop="3.98206" /score="4.77211813" /energy="-6.9" /TU="NA" /idTUdmin="U2307" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2549698..2550516) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator subunit offlagellar rotation" /protein_id="NP_390851.1" /db_xref="EnsemblGenomes-Gn:BSU29730" /db_xref="EnsemblGenomes-Tr:CAB14951" /db_xref="GOA:P39063" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10365" /db_xref="UniProtKB/Swiss-Prot:P39063" /translation="MKRFDYLTPVGFVLGTIIIVIGIISGSGVSGFRSFLDLTSFFIV TGGLCAAVFISFPPSELKKAPSVLKQAFIRQEDNVKDLVKTFVSLSDHARKHGLLSLD DQAREIKDPFLKKGLLLAIDGWDEETIRLVMDSEIAAMEERHRKGRRVFEKAGEFAPA WGMIGTLVGLVLMLKNLNDPHMLGPNMAIALLTTLYGSLLANMVFNPIAAKLEEKTES EIFIKQVMVEGIIGVQSGKNPRNLESQLVVFSSREEWQKQPKQVKTKKGSVHEA*" /label="motP CDS" gene complement(2549698..2550516) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /label="motP gene" CDS complement(2550579..2551583) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catabolite repression (Lacl family)" /protein_id="NP_390852.1" /db_xref="EnsemblGenomes-Gn:BSU29740" /db_xref="EnsemblGenomes-Tr:CAB14952" /db_xref="GOA:P25144" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR006377" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="PDB:1ZVV" /db_xref="PDB:2FEP" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10376" /db_xref="UniProtKB/Swiss-Prot:P25144" /translation="MSNITIYDVAREANVSMATVSRVVNGNPNVKPTTRKKVLEAIER LGYRPNAVARGLASKKTTTVGVIIPDISSIFYSELARGIEDIATMYKYNIILSNSDQN MEKELHLLNTMLGKQVDGIVFMGGNITDEHVAEFKRSPVPIVLAASVEEQEETPSVAI DYEQAIYDAVKLLVDKGHTDIAFVSGPMAEPINRSKKLQGYKRALEEANLPFNEQFVA EGDYTYDSGLEALQHLMSLDKKPTAILSATDEMALGIIHAAQDQGLSIPEDLDIIGFD NTRLSLMVRPQLSTVVQPTYDIGAVAMRLLTKLMNKEPVEEHIVELPHRIELRKSTKS *" /label="ccpA CDS" gene complement(2550579..2551583) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /label="ccpA gene" downshifts complement(2550596) /Source="Nicolas_upshifts" /id="D1532" /incds=0 /nref=62 /ntot=239 /MaxReadThrough="4.60553" /MaxDrop="4.6531" /score="5.3377823" /energy="-13.2" /TU="U2307,U2308,U2309" /idTUdmin="U2306" /TUdmin=3 /isTUend="TRUE" /label="downshifts" misc_feature complement(2551618..2551637) /Source="Nicolas_upshift_promotors" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2551633) /Source="Nicolas_upshifts" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2551635..2551743) /Source="Nicolas_S_feature" /locus_tag="new_3045221_3045329_c" /HighExp="Oxctl, H2O2, Paraq, MG-0.1, MG-0.2, G150, GM 15, Diami, LBGexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigB" /TUshortPSig="0.988, 1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1139" promotor_-10 complement(2551743..2551762) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2551743) /Source="Nicolas_upshifts" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2551745..2551810) /Source="Nicolas_S_feature" /locus_tag="new_3045331_3045396_c" /HighExp="BMM, GM 120, Diami, GM 90, M/G, GM 25, M9-exp, HiTm, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1140" promotor_-35 complement(2551776..2551782) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2551856) /Source="Nicolas_upshifts" /id="D1533" /incds=0 /nref=66 /ntot=188 /MaxReadThrough="6.10221" /MaxDrop="6.29667" /score="46.0872381" /energy="-11.3" /TU="U2308,U2309,U2310" /idTUdmin="U2311" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2551859..2552935) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /EC_number="2.5.1.54" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4200844, 7496534, 11444986, 16339761, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4200844, 7496534, 11444986, 16339761, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional chorismate mutase type II-isozyme 3(regulatory domain); 3-deoxy-D-arabino-heptulosonate7-phosphate synthase" /protein_id="NP_390853.1" /db_xref="EnsemblGenomes-Gn:BSU29750" /db_xref="EnsemblGenomes-Tr:CAB14953" /db_xref="GOA:P39912" /db_xref="InterPro:IPR002701" /db_xref="InterPro:IPR006218" /db_xref="InterPro:IPR006268" /db_xref="InterPro:IPR010954" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036979" /db_xref="PDB:5GMU" /db_xref="PDB:5GO2" /db_xref="SubtiList:BG10375" /db_xref="UniProtKB/Swiss-Prot:P39912" /translation="MSNTELELLRQKADELNLQILKLINERGNVVKEIGKAKEAQGVN RFDPVRERTMLNNIIENNDGPFENSTIQHIFKEIFKAGLELQEEDHSKALLVSRKKKP EDTIVDIKGEKIGDGQQRFIVGPCAVESYEQVAEVAAAAKKQGIKILRGGAFKPRTSP YDFQGLGVEGLQILKRVADEFDLAVISEIVTPAHIEEALDYIDVIQIGARNMQNFELL KAAGAVKKPVLLKRGLAATISEFINAAEYIMSQGNDQIILCERGIRTYETATRNTLDI SAVPILKQETHLPVFVDVTHSTGRRDLLLPTAKAALAIGADGVMAEVHPDPSVALSDS AQQMAIPEFEKWLNELKPMVKVNA*" /label="aroX CDS" gene complement(2551859..2552935) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /label="aroX gene" promotor_-10 complement(2552976..2552995) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-10" upshifts complement(2552996) /Source="Nicolas_upshifts" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="upshifts" S_feature complement(2552998..2553098) /Source="Nicolas_S_feature" /locus_tag="new_3046584_3046684_c" /HighExp="Lbtran, BMM, dia5, GM 25, GM 90, M9-exp, MG 150, Diami, MG-0.2, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigH" /TUshortPSig="0.974, 1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1141" promotor_-35 complement(2553010..2553017) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-35" downshifts 2553032 /Source="Nicolas_upshifts" /id="D1534" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.07872" /MaxDrop="3.23284" /score="1.10447256" /energy="-7.6" /TU="NA" /idTUdmin="U2304" /TUdmin=4071 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2553086..2553105) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2553098) /Source="Nicolas_upshifts" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2553119..2553125) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2553171..2553497) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22938038, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22938038, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin involved in debacillithiolation" /protein_id="NP_390854.1" /db_xref="EnsemblGenomes-Gn:BSU29760" /db_xref="EnsemblGenomes-Tr:CAB14954" /db_xref="InterPro:IPR022551" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10373" /db_xref="UniProtKB/Swiss-Prot:P39914" /translation="MAKQLIQSEEEFKRIAEQEGVFVFLKHSTTCPISQAAFHEFDAF ANQHEDVPAYYLQVQEARPLSNFIAETYGVKHESPQIFIIQNGEVKWHTSHSQITEAA IEQHLS*" /label="brxJ CDS" gene complement(2553171..2553497) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /label="brxJ gene" downshifts complement(2553180) /Source="Nicolas_upshifts" /id="D1535" /incds=0 /nref=144 /ntot=286 /MaxReadThrough="7.09736" /MaxDrop="5.96753" /score="13.8032115" /energy="-7.6" /TU="U2310,U2311" /idTUdmin="U2313" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2553521..2553976) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8733232, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390855.2" /db_xref="EnsemblGenomes-Gn:BSU29770" /db_xref="EnsemblGenomes-Tr:CAB14955" /db_xref="InterPro:IPR024623" /db_xref="SubtiList:BG10975" /db_xref="UniProtKB/Swiss-Prot:P40780" /translation="MSKDGINSKDFLIGTLIGGIIGATTALFLAPKSGKELRDDLGSQ AVALRDKTDKMTADAKEKGTQYVSIAKDKTSNITQLVADQSGQIMNKVKDLRDRSKSD KTDSSTAMQDMREEAMQAADETKDQVLQTKEDVKDELKDAQKQAEQLNR*" /label="ytxH CDS" gene complement(2553521..2553976) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /label="ytxH gene" CDS complement(2554007..2554429) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22720735, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein" /protein_id="NP_390856.2" /db_xref="EnsemblGenomes-Gn:BSU29780" /db_xref="EnsemblGenomes-Tr:CAB14956" /db_xref="GOA:P40779" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG10974" /db_xref="UniProtKB/Swiss-Prot:P40779" /translation="MIIILYLSVALIAVAFLVLVIYLSKTLKSLQLTLKNVASTLEGL EGQMKGITTETAELLHKTNRLAEDIQEKSEKLNTVVHAVQGVGASVQQFNTSMKQAAG SVSASVRENQDKINQVVTWSQAAMEIWEKWKQKKKSAL*" /label="ytxG CDS" gene complement(2554007..2554429) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /label="ytxG gene" promotor_-10 complement(2554450..2554468) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2554463) /Source="Nicolas_upshifts" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2554482..2554488) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2554502..2554520) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-10" upshifts complement(2554511) /Source="Nicolas_upshifts" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="upshifts" promotor_-35 complement(2554531..2554539) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-35" CDS complement(2554591..2555889) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /EC_number="6.3.2.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10565540, 12682299, 12781748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetyl muramate-alanine ligase" /protein_id="NP_390857.1" /db_xref="EnsemblGenomes-Gn:BSU29790" /db_xref="EnsemblGenomes-Tr:CAB14957" /db_xref="GOA:P40778" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005758" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10973" /db_xref="UniProtKB/Swiss-Prot:P40778" /translation="MTVYHFVGIKGTGMSPLAQILHDNGYTVQGSDIEKFIFTQTALE KRNITILPFSAENIKPGMTVIAGNAFPDTHPEIEKAMSEGIPVIRYHKFLGDYMKKFT SVAVTGAHGKTSTTGLLAHVIQNAKPTSFLIGDGTGQGNENSEYFVFEACEYRRHFLS YQPDYAIMTNIDFDHPDYFSSIDDVFDAFQEMALQVNKGIIACGDDEHLPKIHANVPV VYYGTGEENDFQARNIVKSTEGTTFDVFVRNTFYDTFYIPAYGHHNVLNSLAVIALCH YEEIDSSIIKHALKSFGGVKRRFNEKQLGDQVLIDDYAHHPTEIKVTIEAARQKYPDR EIVAVFQPHTFTRTQQFLDEFAESLSGADCVYLCDIFGSARENAGKLTIGDLQGKIHN AKLIEEDDTSVLKAHDKAVLIFMGAGDIQKYMRAYENVMA*" /label="murC CDS" gene complement(2554591..2555889) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /label="murC gene" downshifts complement(2554600) /Source="Nicolas_upshifts" /id="D1536" /incds=0 /nref=29 /ntot=180 /MaxReadThrough="5.23049" /MaxDrop="5.42617" /score="15.3729968" /energy="-7.5" /TU="U2313,U2314" /idTUdmin="U2312" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2555914..2555933) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2555915) /Source="Nicolas_upshifts" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2555917..2556113) /Source="Nicolas_S_feature" /locus_tag="new_3049503_3049699_c" /HighExp="Cold, G150, G135, dia15, G180, H2O2, C30, Oxctl, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.938" /label="S1142" promotor_-35 complement(2555946..2555955) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2556096..2556115) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2556113) /Source="Nicolas_upshifts" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2556127..2556133) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2556139..2558997) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /function="8.1: DNA replication, recombination, and repair" /experiment="publication(s) with functional evidences, PMID:3129532, 11134515, 11208805, 19788545, 28110333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3129532, 11134515, 11208805, 19788545, 28110333; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="DNA translocase" /protein_id="NP_390859.2" /db_xref="EnsemblGenomes-Gn:BSU29805" /db_xref="EnsemblGenomes-Tr:CAB14959" /db_xref="GOA:C0SP86" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13906" /db_xref="UniProtKB/Swiss-Prot:C0SP86" /translation="MSWLHKFFDLFLGESEEDAERETKPAQIPQQQEVHHPEGQLKRL EDPKIYYEYPKGKFRFPVVPDGYKNHDLRRRRTPSDEPKSAPRPSAAPYRERPRNEEE QHTYQAAEPAKKPFKPTNIPSPVYGFNQKPSVKKDVPKKPSETLNEPDKSVKEKVTLL SEEIERERGYPASDTQAHSKIESPFFPDTQFEKQPSGVLNRKDTEHDEALAKRPAEPS GNKVPFESGVQQPEKEEPFFPAEQAEEQTPPEMLTDTAAEGLSDSEVGREEPATAEEE QREQQPEKFEEPVFSAELDEEQTAPESQTEAVSEDEKAKEPSDSPVYNHHENAAEGAE SPFVQEEQMDIRQEEPLFTDHEYSSEALAQAETVAKESEEPSESIINNHYDTLGEAQE TKIDVQPDSHTELEKTEHMEQGSKSSTATLENRQEIRADKPREASEEPKKRPGVQEKR TEQSASSQKGPSVPFNVMMLKRDTHKQQKAEERRGSYVFPNVALLDVPPAQVQDDTAW IEEQRQLLDLTLKNFNVRANVVHVTQGPSVTRFEVHPEPGVKVNKITNLSDDIKLSLS AKDIRIEAPIPGKNTIGIEVPNRTSKVVDLRQMIRSSAFRTSKSPLTAALGLDISGNP VVIDLKKMPHGLIAGATGSGKSVCINTILVSLLYKADPSEVKVLLIDPKMVELAPYNK IPHLVSPVITDAKAATAALKWVVEEMERRYELFAHSGVRDIDRFNQLTAEHQMGEKLP YLVVIIDELADLMMVAPNDVEESIARIAQKARACGIHLLVATQRPSVDVITGLIKANI PTRIAFSVSSQVDSRTIIDIAGAEKLLGKGDMLFLENGSGKPVRLQGNFVSDREIDRV VSHVRSQMPPTYLFEQEELVRQGSALKEEDELFYEACEFVVEQNSASTSSLQRRFRIG YNRAARLIDMMEAEGMISEAKGSKPREVLITASDLINE*" /label="sftA CDS" gene complement(2556139..2558997) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /label="sftA gene" promotor_-10 complement(2559031..2559050) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-10" upshifts complement(2559041) /Source="Nicolas_upshifts" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="upshifts" promotor_-35 complement(2559066..2559070) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-35" downshifts complement(2559140) /Source="Nicolas_upshifts" /id="D1537" /incds=0 /nref=186 /ntot=249 /MaxReadThrough="4.47299" /MaxDrop="6.35097" /score="9.62039509" /energy="-14.5" /TU="U2315" /idTUdmin="U2315" /TUdmin="-1553" /isTUend="FALSE" /label="downshifts" CDS complement(2559157..2559762) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21949854, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA binding enzyme" /protein_id="NP_390860.1" /db_xref="EnsemblGenomes-Gn:BSU29820" /db_xref="EnsemblGenomes-Tr:CAB14960" /db_xref="GOA:O34943" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027855" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR037154" /db_xref="SubtiList:BG13905" /db_xref="UniProtKB/Swiss-Prot:O34943" /translation="MNAFYNKEGVGDTLLISLQDVTREQLGYEKHGDVVKIFNNETKE TTGFNIFNASSYLTIDENGPVALSETFVQDVNEILNRNGVEETLVVDLSPKFVVGYVE SKEKHPNADKLSVCKVNVGEETLQIVCGAPNVDQGQKVVVAKVGAVMPSGLVIKDAEL RGVPSSGMICSAKELDLPDAPAEKGILVLEGDYEAGDAFQF*" /label="ytpR CDS" gene complement(2559157..2559762) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /label="ytpR gene" CDS complement(2559778..2560587) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12719520, 21949854" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (iron homeostasis)" /protein_id="NP_390861.1" /db_xref="EnsemblGenomes-Gn:BSU29830" /db_xref="EnsemblGenomes-Tr:CAB14961" /db_xref="InterPro:IPR010838" /db_xref="SubtiList:BG13904" /db_xref="UniProtKB/Swiss-Prot:O34496" /translation="MKMTSRKLSDILKQRLQHENRSFLFDREKDTLRVEDQTTKKGIT LDLPPIIAKWELKKDEAIDEIVYYVSEAMTAMEGKAQEMTGKETRIYPVIRSTSFPDK SSEDIPLIYDDHTAETRIYYALDLGKTYRLIDQRMLEKENWTKERIRETAAFNLRSLP TVVKEDTVAGNYFYFFRANDGYDASRILNEAILNEYKQHAEGELAISVPHQDVLILAD IRNESGYDILGQMSMSFFAGGTVPITALSFLYNEGKLEPVFILAKSRPKKD*" /label="ytpQ CDS" gene complement(2559778..2560587) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /label="ytpQ gene" CDS complement(2560602..2560925) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12719520, 15937154, 21949854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_390862.1" /db_xref="EnsemblGenomes-Gn:BSU29840" /db_xref="EnsemblGenomes-Tr:CAB14962" /db_xref="GOA:O34357" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13903" /db_xref="UniProtKB/Swiss-Prot:O34357" /translation="MKKIESTQELEKAVKDDWSVFMFSADWCPDCRFVEPFLPELEAN FPEFTYYYVDRDKFIDTCAEWEIYGIPSFVVFNEGKEVNRFVSKDRKTKEEIEQFLTD SLAKA*" /label="ytpP CDS" gene complement(2560602..2560925) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /label="ytpP gene" S_feature complement(2560926..2561064) /Source="Nicolas_S_feature" /locus_tag="new_3054512_3054650_c" /HighExp="G180, G150, Paraq, Oxctl, H2O2, Diami, C90, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.32150299999999998" /TUshortSig="SigA" /TUshortPSig="0.938" /TUlongSig="NA" /TUlongPSig="NA" /label="S1143" CDS complement(2560964..2561080) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513998.1" /translation="MQIKYDNDNGKANLTYSFVAYKWFCLKQFGMIQMDEYR*" /label="hypothetical protein CDS" gene complement(2560964..2561080) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /label="gene" promotor_-10 complement(2561051..2561070) /Source="Nicolas_upshift_promotors" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="promotor_-10" upshifts complement(2561064) /Source="Nicolas_upshifts" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="upshifts" promotor_-35 2561072..2561079 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2561094..2561113 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2561099 /Source="Nicolas_upshifts" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="upshifts" CDS 2561160..2561606 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with sugar binding fold" /protein_id="NP_390863.1" /db_xref="EnsemblGenomes-Gn:BSU29850" /db_xref="EnsemblGenomes-Tr:CAB14963" /db_xref="InterPro:IPR019884" /db_xref="SubtiList:BG13899" /db_xref="UniProtKB/Swiss-Prot:O34305" /translation="MEFIVYLAGEIHSNWREEIKEKTKSLKLPITFVGPMENHDRSDN IGEEIMGVQPNAVLKDDKASDINNFRTAVLMNKADFVIALFGEKYKQWNTAMDASYAI AKGKPLIIIRPESLHHPLKELSNKANITVETVNQAIKALSYLFETE*" /label="ytoQ CDS" gene 2561160..2561606 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /label="ytoQ gene" S_feature 2561607..2562335 /Source="Nicolas_S_feature" /locus_tag="new_3055193_3055921" /HighExp="H2O2, dia15, C30, C90, Diami, S1, M0t45, Salt, Paraq, Lbexp" /AntisenseName="ytoP" /AntisenseCor="0.35418735783791" /AntisenseRegPval="-8.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.981" /TUlongSig="NA" /TUlongPSig="NA" /label="S1144" CDS complement(2561661..2562734) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8535515; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative modified amino acid aminopeptidase" /protein_id="NP_390864.1" /db_xref="EnsemblGenomes-Gn:BSU29860" /db_xref="EnsemblGenomes-Tr:CAB14964" /db_xref="GOA:O34924" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13898" /db_xref="UniProtKB/Swiss-Prot:O34924" /translation="MNQETKALFQTLTQLPGAPGNEHQVRAFMKQELAKYADDIVQDR LGSVFGVRRGAEDAPRIMVAGHMDEVGFMVTSITDNGLLRFQTLGGWWSQVLLAQRVE IQTDNGPVPGVISSIPPHLLTDAQRNRPMDIKNMMIDIGADDKEDAIKIGIRPGQQIV PVCPFTTMANEKKILSKAWDNRYGCGLSIELLKELHGKELPNTLYAGATVQEEVGLRG AQTASHMIKPDLFFALDASPANDMSGDKNEFGQLGKGFLLRILDRTTVMHRGMREFVL DMAETHDIPYQYFVSGGGTDAGKVHISNSGVPSAVIGICSRYIHTNATIIHIDDYAAA KEMLIKLVTACDKQTVDAIKENM*" /label="ytoP CDS" gene complement(2561661..2562734) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /label="ytoP gene" downshifts complement(2561680) /Source="Nicolas_upshifts" /id="D1538" /incds=0 /nref=140 /ntot=248 /MaxReadThrough="1.89952" /MaxDrop="4.55096" /score="14.9571314" /energy="-14.4" /TU="NA" /idTUdmin="U2317" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2562756..2562775) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2562760) /Source="Nicolas_upshifts" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2562789..2562796) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2562831..2562834 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2562849..2562868 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2562854 /Source="Nicolas_upshifts" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="upshifts" CDS 2562893..2563210 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390865.1" /db_xref="EnsemblGenomes-Gn:BSU29870" /db_xref="EnsemblGenomes-Tr:CAB14965" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13936" /db_xref="UniProtKB/Swiss-Prot:O32065" /translation="MKLRHLLLGAGLGICTAVVVRQYVMKPYISSEKALRIVKSAFKQ RGPIDGSWIYTQPEPYNINGETVQVYKTGITRSAFGELEQYEVMVDAKTGEIVDVIDT IAS*" /label="ytzB CDS" gene 2562893..2563210 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /label="ytzB gene" downshifts 2563210 /Source="Nicolas_upshifts" /id="D1539" /incds=0 /nref=250 /ntot=259 /MaxReadThrough="1.29231" /MaxDrop="7.83082" /score="44.9062865" /energy="-17" /TU="NA" /idTUdmin="U2318" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2563263..2564963) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 20933603, 22740702, 23136871, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_390866.1" /db_xref="EnsemblGenomes-Gn:BSU29880" /db_xref="EnsemblGenomes-Tr:CAB14966" /db_xref="GOA:O34389" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG12614" /db_xref="UniProtKB/Swiss-Prot:O34389" /translation="MKQFRVTNEGDIQTTLRGLEVLSVPFLNKGVAFTEEERKELGLK GFLPPKVLTIDDQAKRAYEQYSAQPDDLSKNVYLTALHDRNETLFYRLLNDHLGEMLP IVYTPTVGTAIQRYSHEYRKPRGLYLSIDDPDGMKEAFKQYKDQSDTIDLIVATDAEG ILGIGDWGVGGIAISIGKLAVYTAAAGIDPSRVLAVVLDAGTNQESLLNDPLYVGNQH SRVRGERYDQFIDDYVALARETFPNALLHWEDFGAKNARSILKRYKDKVCTFNDDIQG TGAVSLAAVLSCAKASKVPLRDHRVVIFGAGTAGIGIAEQLREALVREGLSEEESYKR FWCIDRNGLLTDDMDQLLDFQKPYARSADEVKDYQRNGDGGGIDLLEVVRQAKPTILI GTSTVSGAFTEEIVKEMASHVKRPAILPMSNPTTLSEAKPEDLIEWTEGRALITTGSP FPPVEYNGVTYHIGQANNALVFPGLGLGTIVTKSKLITDGMFEACARAIAGMVNVGVP GAPMLPKVEDLRTVSATVAVEVAKTAMKEGVATEEPEDIIQAVQDAMWYPVYKPIRAI *" /label="maeC CDS" gene complement(2563263..2564963) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /label="maeC gene" downshifts complement(2563282) /Source="Nicolas_upshifts" /id="D1540" /incds=0 /nref=77 /ntot=255 /MaxReadThrough="2.4872" /MaxDrop="4.99085" /score="17.675308" /energy="-15.3" /TU="NA" /idTUdmin="U2319" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2564995..2565013) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2565002) /Source="Nicolas_upshifts" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2565028..2565034) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2565045..2565815) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22101040, 24268182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative quorum-quenching lactonase" /protein_id="NP_390867.1" /db_xref="EnsemblGenomes-Gn:BSU29890" /db_xref="EnsemblGenomes-Tr:CAB14967" /db_xref="GOA:O34760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13895" /db_xref="UniProtKB/Swiss-Prot:O34760" /translation="MFGVVPKPLWSKKYPVNEKNQIELRTDPILIQKDGLNIIIDAGI GYGKLTDKQKRNYGVTQESNVKPSLAALGLTVADIDVIAMTHLHFDHACGLTEYEGER LVSVFPNAVIYTSAVEWDEMRHPNIRSKNTYWKENWEAVAGQVKTFEDTLTITEGITM HHTGGHSDGHSVLICEDAGETAVHMADLMPTHAHRNPLWVLAYDDYPMTSIPQKQKWQ AFAAEKDAWFIFYHDAEYRALQWEEDGSIKKSVKRMKR*" /label="ytnP CDS" gene complement(2565045..2565815) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /label="ytnP gene" S_feature complement(2565816..2565904) /Source="Nicolas_S_feature" /locus_tag="new_3059402_3059490_c" /HighExp="HiOs, M40t90, T0.30H, T1.30H, T3.0H, T1.0H, Sw, T2.30H, T3.30H, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1145" promotor_-10 complement(2565902..2565921) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2565904) /Source="Nicolas_upshifts" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2565937..2565941) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2565961..2566602) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /EC_number="2.1.1.33" /function="16.6: Maintain" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15789416, 16600901, 17150909, 19934251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15789416, 16600901, 17150909, 19934251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (guanine-N(7)-)-methyltransferase" /protein_id="NP_390868.1" /db_xref="EnsemblGenomes-Gn:BSU29900" /db_xref="EnsemblGenomes-Tr:CAB14968" /db_xref="GOA:O34522" /db_xref="InterPro:IPR003358" /db_xref="InterPro:IPR029063" /db_xref="PDB:2FCA" /db_xref="SubtiList:BG13890" /db_xref="UniProtKB/Swiss-Prot:O34522" /translation="MRMRHKPWADDFLAENADIAISNPADYKGKWNTVFGNDNPIHIE VGTGKGQFISGMAKQNPDINYIGIELFKSVIVTAVQKVKDSEAQNVKLLNIDADTLTD VFEPGEVKRVYLNFSDPWPKKRHEKRRLTYSHFLKKYEEVMGKGGSIHFKTDNRGLFE YSLKSFSEYGLLLTYVSLDLHNSNLEGNIMTEYEEKFSALGQPIYRAEVEWRT*" /label="trmB CDS" gene complement(2565961..2566602) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /label="trmB gene" downshifts complement(2565971) /Source="Nicolas_upshifts" /id="D1541" /incds=0 /nref=46 /ntot=131 /MaxReadThrough="3.31031" /MaxDrop="5.64644" /score="29.2137061" /energy="-10.1" /TU="NA" /idTUdmin="U2321" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(2566036) /Source="Nicolas_upshifts" /id="D1542" /incds=1 /nref=39 /ntot=202 /MaxReadThrough="6.31908" /MaxDrop="3.64275" /score="29.2137061" /energy="-10.1" /TU="U2321,U2323" /idTUdmin="U2323" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2566628..2566647) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2566637) /Source="Nicolas_upshifts" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2566639..2567087) /Source="Nicolas_S_feature" /locus_tag="new_3060225_3060673_c" /HighExp="C30, Cold, G135, G180, B60, Paraq, G150, Oxctl, H2O2, LBGstat" /AntisenseName="ytzH" /AntisenseCor="-0.51149457663808795" /AntisenseRegPval="-18.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1146" promotor_-35 complement(2566663..2566667) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2566746..2566752 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2566767..2566778 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2566774 /Source="Nicolas_upshifts" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="upshifts" CDS 2566809..2567087 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390869.1" /db_xref="EnsemblGenomes-Gn:BSU29910" /db_xref="EnsemblGenomes-Tr:CAB14969" /db_xref="InterPro:IPR025547" /db_xref="SubtiList:BG13942" /db_xref="UniProtKB/Swiss-Prot:O32066" /translation="MGLHYEHQVHLLKDILTDHQLDCCGTVAEYEQLERVIKSLMANT ELDSNFKNVLEDVYRYSQSGISSKSIDSHIQEHQNSLSQWVEQMDSYS*" /label="ytzH CDS" gene 2566809..2567087 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /label="ytzH gene" S_feature 2567088..2567258 /Source="Nicolas_S_feature" /locus_tag="new_3060674_3060844" /HighExp="S5, S7, S8, S6, S4, BT, C30, nit, ferm, G/S" /AntisenseName="ytmP" /AntisenseCor="-0.32108027439793901" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1147" CDS complement(2567088..2567702) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9026440, 11545674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase/phosphotransferase" /protein_id="NP_390870.2" /db_xref="EnsemblGenomes-Gn:BSU29920" /db_xref="EnsemblGenomes-Tr:CAB14970" /db_xref="GOA:C0SPC1" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG13889" /db_xref="UniProtKB/Swiss-Prot:C0SPC1" /translation="MENGDVITAQHWMTGRELKPKDMSGRPVAELLRKIHTSKALLDM LKRLGKEPLNPGALLSQLKQAVFAVQQSSPLIQEGIKYLEEHLHEVHFGEKVVCHCDV NHNNWLLSEDNQLYLIDWDGAMIADPAMDLGPLLYHYVEKPAWESWLSMYGIELTESL RLRMAWYVLSETITFIAWHKAKGNDKEFHDAMEELHILMKRIVD*" /label="ytmP CDS" gene complement(2567088..2567702) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /label="ytmP gene" downshifts 2567236 /Source="Nicolas_upshifts" /id="D1543" /incds=1 /nref=4 /ntot=35 /MaxReadThrough="2.54837" /MaxDrop="3.82368" /score="-4.89809956" /energy="-11.3" /TU="NA" /idTUdmin="U2322" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2567703..2568038) /Source="Nicolas_S_feature" /locus_tag="new_3061289_3061624_c" /HighExp="T1.30H, M9-stat, T2.30H, T3.0H, UNK1, B60, T2.0H, T3.30H, T1.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1148" promotor_-10 complement(2568030..2568049) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2568038) /Source="Nicolas_upshifts" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2568064..2568071) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2568065..2570221) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /EC_number="3.2.1.41" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9453151, 16582490, 19465663, 23973973" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9453151, 16582490, 19465663, 23973973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pullulanase" /protein_id="NP_390871.2" /db_xref="EnsemblGenomes-Gn:BSU29930" /db_xref="EnsemblGenomes-Tr:CAB14971" /db_xref="GOA:C0SPA0" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR011840" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="PDB:2E8Y" /db_xref="PDB:2E8Z" /db_xref="PDB:2E9B" /db_xref="SubtiList:BG12566" /db_xref="UniProtKB/Swiss-Prot:C0SPA0" /translation="MVSIRRSFEAYVDDMNIITVLIPAEQKEIMTPPFRLETEITDFP LAVREEYSLEAKYKYVCVSDHPVTFGKIHCVRASSGHKTDLQIGAVIRTAAFDDEFYY DGELGAVYTADHTVFKVWAPAATSAAVKLSHPNKSGRTFQMTRLEKGVYAVTVTGDLH GYEYLFCICNNSEWMETVDQYAKAVTVNGEKGVVLRPDQMKWTAPLKPFSHPVDAVIY ETHLRDFSIHENSGMINKGKYLALTETDTQTANGSSSGLAYVKELGVTHVELLPVNDF AGVDEEKPLDAYNWGYNPLHFFAPEGSYASNPHDPQTRKTELKQMINTLHQHGLRVIL DVVFNHVYKRENSPFEKTVPGYFFRHDECGMPSNGTGVGNDIASERRMARKFIADCVV YWLEEYNVDGFRFDLLGILDIDTVLYMKEKATKAKPGILLFGEGWDLATPLPHEQKAA LANAPRMPGIGFFNDMFRDAVKGNTFHLKATGFALGNGESAQAVMHGIAGSSGWKALA PIVPEPSQSINYVESHDNHTFWDKMSFALPQENDSRKRSRQRLAAAIILLAQGVPFIH SGQEFFRTKQGVENSYQSSDSINQLDWDRRETFKEDVHYIRRLISLRKAHPAFRLRSA ADIQRHLECLTLKEHLIAYRLYDLDEVDEWKDIIVIHHASPDSVEWRLPNDIPYRLLC DPSGFQEDPTEIKKTVAVNGIGTVILYLASDLKSFA*" /label="amyX CDS" gene complement(2568065..2570221) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /label="amyX gene" Polymorphism join(2569762,2569764) /Source="geneious" /ID="SNP_BsDelta6_3063349_3063349" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=459 /Change="A -> G" /Codon_Change="GTT -> GTC" /Coverage=168 /locus_tag="BSU_29930" /Protein_Effect="None" /Reference_Frequency="1.2%" /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=165 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(2570247..2571176) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /EC_number="2.7.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospholipid kinase" /protein_id="NP_390872.1" /db_xref="EnsemblGenomes-Gn:BSU29940" /db_xref="EnsemblGenomes-Tr:CAB14972" /db_xref="GOA:O34799" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13880" /db_xref="UniProtKB/Swiss-Prot:O34799" /translation="MSHWFFIINPTAGHRNGLRVWKSIQKELIKRKVEHRSFLTEHPG HAEVLARQISTIQEYKLKRLIVIGGDGTMHEVVNGLKDVDDIELSFVPAGAYNDFSRG FSIKKIDLIQEIKKVKRPLTRTFHLGSVNFLQDKSQILYFMNHIGIGFDAYVNKKAME FPLRRVFLFLRLRFLVYPLSHLHASATFKPFTLACTTEDETREFHDVWFAVVSNHPFY GGGMKAAPLANPREKTFDIVIVENQPFLKKYWLLCLMAFGKHTKMDGVTMFKAKDITF YTKDKIPFHADGEIMGTTPFRLASSPSPLRIKT*" /label="ytlR CDS" gene complement(2570247..2571176) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /label="ytlR gene" CDS complement(2571225..2572139) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390873.1" /db_xref="EnsemblGenomes-Gn:BSU29950" /db_xref="EnsemblGenomes-Tr:CAB14973" /db_xref="InterPro:IPR012397" /db_xref="SubtiList:BG13879" /db_xref="UniProtKB/Swiss-Prot:O34471" /translation="MAQIIKIHDYISRYELDPYHYINQFVRLKKERWLSLVEAAERQH EERQASAEEPEPVQKRKKFSLKRRKEEIKADIQEERHQWFEDEEDIHVRLPKSRVALA SFYKRHLYDFQLKWASSTLSEISQLSNQVKQDRILRYLTQQLPDSYFIMYKPVLKIQQ AAVELSIVIISPLEIYCVSFLEAEEDSVYIGSKNRFWDKKTASQTASVLNPGLSLFRT DSVVSKIVKEKQAEIPVRKLLLSRTSYIDYPEPPYGLEIADKRSAEEWIERQKKNTAP IKHHQVKAAKALLSYCMSDSYRRQEWLE*" /label="ytlQ CDS" gene complement(2571225..2572139) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /label="ytlQ gene" promotor_-10 complement(2571902..2571920) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2571910) /Source="Nicolas_upshifts" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="upshifts" promotor_-35 complement(2571934..2571940) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" CDS complement(2572165..2572716) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /EC_number="3.1.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17012785; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA 2',3'-cyclic phosphodiesterase" /protein_id="NP_390874.1" /db_xref="EnsemblGenomes-Gn:BSU29960" /db_xref="EnsemblGenomes-Tr:CAB14974" /db_xref="GOA:O34570" /db_xref="InterPro:IPR004175" /db_xref="InterPro:IPR009097" /db_xref="SubtiList:BG13878" /db_xref="UniProtKB/Swiss-Prot:O34570" /translation="MPDIRPHYFIGVPIPEGIANPIYQAAKNEPILTFQKWVHPLDYH ITLIFLGAADETQIKKLEGSLAEIASEIDPFSIKFGKIDVFGDRRKPRVLHLEPKKNK TLDRLREHTKQAVLQAGFQVEKRPYHPHMTLARKWTGEDGFPAHVPFESGEVSMMAER FSLFQIHLNQSPKYEEIFKFQLS*" /label="ytlP CDS" gene complement(2572165..2572716) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /label="ytlP gene" misc_feature 2572579..2572598 /Source="Nicolas_upshift_promotors" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2572582 /Source="Nicolas_upshifts" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2572739..2572758) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2572751) /Source="Nicolas_upshifts" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="upshifts" promotor_-35 complement(2572774..2572777) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" promotor_-35 2572799..2572806 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2572817..2572836 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2572820..2572831) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2572824 /Source="Nicolas_upshifts" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2572834) /Source="Nicolas_upshifts" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2572845..2572851) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2572865..2573800 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cysteine synthase-like enzyme" /protein_id="NP_390875.1" /db_xref="EnsemblGenomes-Gn:BSU29970" /db_xref="EnsemblGenomes-Tr:CAB14975" /db_xref="GOA:O34476" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG13872" /db_xref="UniProtKB/Swiss-Prot:O34476" /translation="MLKIVANTADLIGDTPLVRLNRLQPENAAQVYLKLEFFNPSGSV KDRAAYQMIIEAEQNGLLKPGSVIIEPTSGNTGIGLAMNAAARGYKAILVMPDTMTKE RINLLKAYGAEVVLTPGEERMPGSIKKAKELAEQIPNSYIPMQFDNTANPDAHRKTTA PEIARAIEEIGKPLGAFVASSGTGGTITGTGEALKELFPDITVHVVEPAGSPVLSGGK PGAHKLVGTSPGFIPPILNEDVYDEIIKISDEDAYTTTRRLAAEEGILVGPSSGAACF AAIETAKRLSPDKVVVCMTADTGERYLSTDLWSFI*" /label="ytkP CDS" gene 2572865..2573800 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /label="ytkP gene" downshifts 2573776 /Source="Nicolas_upshifts" /id="D1544" /incds=0 /nref=74 /ntot=225 /MaxReadThrough="2.5873" /MaxDrop="4.59197" /score="29.2734118" /energy="-18.2" /TU="NA" /idTUdmin="U2327" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" CDS complement(2573834..2575225) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /EC_number="3.5.-.-" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7528082, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative promiscuous peptidase/deacylase" /protein_id="NP_390876.1" /db_xref="EnsemblGenomes-Gn:BSU29980" /db_xref="EnsemblGenomes-Tr:CAB14976" /db_xref="GOA:O34944" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010964" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13867" /db_xref="UniProtKB/Swiss-Prot:O34944" /translation="MNWEVEVIRKKEDLIRDTQEFLRINSVMDETTAGPGKPFGEGVN ASLTSLLELGEKEGFTTKNLDGFAGHIEWGEGDDIIGVLCHVDVVPPGDGWTSDPFSA EIRNGRIYARGAIDDKGPTMAAFYALKIVKDMNLPLSKRVRMIIGTDEESDWRCVEHY FKHEEMPTMGFAPDADFPIINAEKGIIDASLLIPHRPNQAEPKAVLVSFQSGLRLNMV PDAAEAVIEGPKNEEILSSFKDMLRTTDQKGEAAIENGQLILRMYGLSCHAMEPNNGI NAGILLCEFLQQTELDDAGKRFVQVVTDKFSGDTRGKKLDIDCEDEISGELTLNVGTL RYKEGQGGELGINIRYPVTAESKVIRDTFESASEFELGEFKDSKPHHVSADHPLVKTL QKVYEGQLGKKADLISIGGGTYARSLKAGVAFGPLFPGRPDSAHQKDEYIEIDDLLRS TALYAQAIYELAK*" /label="ytjP CDS" gene complement(2573834..2575225) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /label="ytjP gene" downshifts complement(2573846) /Source="Nicolas_upshifts" /id="D1545" /incds=0 /nref=63 /ntot=240 /MaxReadThrough="3.38616" /MaxDrop="3.73023" /score="23.9099234" /energy="-14.4" /TU="U2330" /idTUdmin="U2330" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" S_feature complement(2575226..2575666) /Source="Nicolas_S_feature" /locus_tag="new_3068812_3069252_c" /HighExp="Etha, Salt, M40t90, Lbtran, T1.30H, M0t90, Lbstat, T1.0H, T0.30H, LBGstat" /AntisenseName="pbuO" /AntisenseCor="-0.324692399913451" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1149" promotor_-35 2575252..2575257 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2575271..2575290 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2575284 /Source="Nicolas_upshifts" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="upshifts" CDS 2575322..2576620 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11591660, 12923093, 15849754, 16850406, 19446032, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12923093, 15849754, 16850406, 19446032, 28583948; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_390877.1" /db_xref="EnsemblGenomes-Gn:BSU29990" /db_xref="EnsemblGenomes-Tr:CAB14977" /db_xref="GOA:O34978" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG13864" /db_xref="UniProtKB/Swiss-Prot:O34978" /translation="MFHLKEQQTSIKQEIIAGLTTFFTMVYIVVVNPVILANAGVPFD QVFTATIIASIVGTLWMALAANYPIAIAPGMGLNAYLAFHVVSASDGGITYATAFSAV FTAGVLFIILSLTPLRKQLIEAIPNNLKYGITTGIGLFIAFIGLRQAGIVAADESNLV TLGNLHSPGVILTLVGLLISVVLMVLNVSGALFIGMAATALIAFFTGQLHFSKGFMSL PHLPEGLMISNPFTAFGDVIHHGLYAVVFSFLLVTIFDTTGTMIGVAEQAGLMKNNKL PNVRKALLADSTATTVGAVFGTSPTTAFIESSAGVAAGGRTGLTALTVAVMFAASMFF SPLVSALSGIAAITSPALIIVGSLMMGSVSNMNWKEMDEAFPAFLVILAMPLTSSIST GIALGFISYPIVKAARGKWREIHPLVIVFAILFFIQLFIL*" /label="pbuO CDS" gene 2575322..2576620 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /label="pbuO gene" promotor_-10 complement(2575643..2575662) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2575666) /Source="Nicolas_upshifts" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2575677..2575683) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2576607 /Source="Nicolas_upshifts" /id="D1546" /incds=0 /nref=43 /ntot=178 /MaxReadThrough="2.37859" /MaxDrop="5.35341" /score="16.9979166" /energy="-10.2" /TU="NA" /idTUdmin="U2329" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2576660..2577817) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390878.1" /db_xref="EnsemblGenomes-Gn:BSU30000" /db_xref="EnsemblGenomes-Tr:CAB14978" /db_xref="GOA:O35029" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG13861" /db_xref="UniProtKB/Swiss-Prot:O35029" /translation="MNGRTLFFRRLFDYYKYQFKVLHAVIDWTVALYIVLPAIAFVIY QYIDLMNGRGLLYEWSEVAEWRWLYAVCVLIMFTGSIRTFLMEADKVFLLQKKEIIYQ LKRYALLYSFLATLAKWLLLFFIVLPLISHSVLITFAESTALLCYLFGLHIFFLSLKQ DRIRKPRSISRWIGDTLVRAILFAGSAILIVFTERHLLALFGILFLFFSVIRSLKKTA SFTAFEAEVTEEKKSRLALAGLVMMMSQEAGMPKVKDRMRRKPLLYRNSKRIFKRRTI CTGYKELFFKVMLRNGEYARQMYMLLSAFTVLIFVSPIWLKVIALLVYTGVCRYILTL IFDKVMDAPFLIGTDKESDEYYRARKSCINILHYAFAACCFLAAAVSLLFT*" /label="ythQ CDS" gene complement(2576660..2577817) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /label="ythQ gene" downshifts complement(2576685) /Source="Nicolas_upshifts" /id="D1547" /incds=0 /nref=1 /ntot=153 /MaxReadThrough="3.07175" /MaxDrop="3.89104" /score="19.8243425" /energy="-11.2" /TU="NA" /idTUdmin="U2332" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2576933..2576938 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2576953..2576971 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2576961 /Source="Nicolas_upshifts" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2577814..2578524) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_390879.1" /db_xref="EnsemblGenomes-Gn:BSU30010" /db_xref="EnsemblGenomes-Tr:CAB14979" /db_xref="GOA:O34977" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13860" /db_xref="UniProtKB/Swiss-Prot:O34977" /translation="MTNLLEASIEQAGYTSRKKVLTDVFLEVRKGELVGLIGANGAGK STAIKAILGLSEDFKGHIAWNDCSFAYIPEHPSFYEELTLWEHLDLISTLHGIEESEF AHRAQSLLQTFSLDHVKHELPVTFSKGMQQKLMLIQAFLSKPDMYVIDEPFIGLDPIS TKRFVDMLKAEKERGAGILMCTHVLDTAEKICDRFYMIEKGSLFLQGTLKDVQDKTGL EGQSLLDCFYKAVQGDRL*" /label="ythP CDS" gene complement(2577814..2578524) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /label="ythP gene" promotor_-10 complement(2578538..2578553) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2578555) /Source="Nicolas_upshifts" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2578565..2578574) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2578581..2578582 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2578594..2578699 /Source="Nicolas_S_feature" /locus_tag="new_3072180_3072285" /HighExp="S5, S4, S3, S8, S7, S6, G/S, Pyr, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1150" upshifts 2578594 /Source="Nicolas_upshifts" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2578602..2578612 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2578665..2578671 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2578686..2578705 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2578701..2578814 /Source="Nicolas_S_feature" /locus_tag="new_3072287_3072400" /HighExp="S4, S5, M0t90, S3, Etha, M9-stat, M40t90, LPhT, Heat, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1151" upshifts 2578701 /Source="Nicolas_upshifts" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2578815..2579036 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618461; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (DeoR family)" /protein_id="NP_390880.1" /db_xref="EnsemblGenomes-Gn:BSU30020" /db_xref="EnsemblGenomes-Tr:CAB14980" /db_xref="GOA:O32067" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13939" /db_xref="UniProtKB/Swiss-Prot:O32067" /translation="MKPSTNRMLTRIKSVYMFIQEKGLVTTQELVDEFGITPRTIQRD LNVLAYNDLVHSPSRGKWETTRKKVKITS*" /label="ytzE CDS" gene 2578815..2579036 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /label="ytzE gene" downshifts 2579019 /Source="Nicolas_upshifts" /id="D1548" /incds=0 /nref=166 /ntot=259 /MaxReadThrough="4.38243" /MaxDrop="4.90218" /score="20.9755494" /energy="-13.5" /TU="U2333,U2334" /idTUdmin="U2333" /TUdmin="-54" /isTUend="FALSE" /label="downshifts" downshifts 2579088 /Source="Nicolas_upshifts" /id="D1549" /incds=0 /nref=44 /ntot=172 /MaxReadThrough="-0.189589999999999" /MaxDrop="6.00369" /score="20.9755494" /energy="-13.5" /TU="NA" /idTUdmin="U2334" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2579157..2579876) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /EC_number="4.2.1.70" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11953756, 16511038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA pseudouridylate 516 synthase" /protein_id="NP_390882.2" /db_xref="EnsemblGenomes-Gn:BSU30035" /db_xref="EnsemblGenomes-Tr:CAB14982" /db_xref="GOA:O32068" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG13941" /db_xref="UniProtKB/Swiss-Prot:O32068" /translation="MRLDKLLANSGYGSRKEVKAVVKAGAVMIDGKPAKDVKEHVDPD TQEVTVYGEPVDYREFIYLMMNKPQGVLSATEDSRQQTVVDLLTPEEMRFEPFPAGRL DKDTEGFLLLTNDGQLAHRLLSPKKHVPKTYEVHLKSQISREDISDLETGVYIEGGYK TKPAKAEIKTNDSGNTVIYLTITEGKYHQVKQMAKAVGNEVVYLKRLSMGRVSLDPAL APGEYRELTEEELHLLNEPQA*" /label="rsuA CDS" gene complement(2579157..2579876) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /label="rsuA gene" downshifts complement(2579171) /Source="Nicolas_upshifts" /id="D1550" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="0.79865" /MaxDrop="2.6873" /score="21.6808891" /energy="-13.5" /TU="NA" /idTUdmin="U2335" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts complement(2579942) /Source="Nicolas_upshifts" /id="D1551" /incds=0 /nref=1 /ntot=76 /MaxReadThrough="4.50848" /MaxDrop="2.99899" /score="8.79816042" /energy="-9.5" /TU="U2335" /idTUdmin="U2335" /TUdmin="-617" /isTUend="FALSE" /label="downshifts" CDS complement(2579945..2581579) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_390883.1" /db_xref="EnsemblGenomes-Gn:BSU30050" /db_xref="EnsemblGenomes-Tr:CAB14983" /db_xref="GOA:O34674" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG13856" /db_xref="UniProtKB/Swiss-Prot:O34674" /translation="MSSKLLRGTFVLTLGTYISRILGMVYLIPFSIMVGATGGALFQY GYNQYTLFLNIATMGFPAAVSKFVSKYNSKGDYETSRKMLKAGMSVMLVTGMIAFFIL YLSAPMFAEISLGGKDNNGLTIDHVVYVIRMVSLALLVVPIMSLVRGFFQGHQMMGPT AVSQVVEQIVRIIFLLSATFLILKVFNGGLVIAVGYATFAALIGAFGGLVVLYIYWNK RKGSLLAMMPNTGPTANLSYKKMFFELFSYAAPYVFVGLAIPLYNYIDTNTFNKAMIE AGHQAISQDMLAILTLYVQKLVMIPVSLATAFGLTLIPTITESFTSGNYKLLNQQINQ TMQTILFLIIPAVVGISLLSGPTYTFFYGSESLHPELGANILLWYSPVAILFSLFTVN AAILQGINKQKFAVVSLVIGVVIKLVLNVPLIKLMQADGAILATALGYIASLLYGFIM IKRHAGYSYKILVKRTVLMLVLSAIMGIAVKIVQWVLGFFISYQDGQMQAAIVVVIAA AVGGAVYLYCGYRLGFLQKILGRRLPGFFRKGRHAG*" /label="murJ CDS" gene complement(2579945..2581579) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /label="murJ gene" misc_feature complement(2581611..2581630) /Source="Nicolas_upshift_promotors" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2581627) /Source="Nicolas_upshifts" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2581697..2581701 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2581717..2581736 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2581735 /Source="Nicolas_upshifts" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2581781..2583043 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(FAD)-utilizing dehydrogenase" /protein_id="NP_390884.2" /db_xref="EnsemblGenomes-Gn:BSU30060" /db_xref="EnsemblGenomes-Tr:CAB14984" /db_xref="InterPro:IPR004792" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13850" /db_xref="UniProtKB/Swiss-Prot:Q795R8" /translation="MKQYDVIVIGGGPSGLMAAIAAGEQGAGVLLIDKGNKLGRKLAI SGGGRCNVTNRLPVEEIIKHIPGNGRFLYSAFSEFNNEDIIKFFENLGIQLKEEDHGR MFPVTDKAQSVVDALLNRLKQLRVTIRTNEKIKSVLYEDGQAAGIVTNNGEMIHSQAV IIAVGGKSVPHTGSTGDGYEWAEAAGHTITELFPTEVPVTSGEPFIKQKTLQGLSLRD VAVSVLNKKGKPIITHKMDMLFTHFGLSGPAILRCSQFVVKELKKQPQVPIRIDLYPD INEETLFQKMYKELKEAPKKTIKNVLKPWMQERYLLFLLEKNGISPNVSFSELPKDPF RQFVRDCKQFTVLANGTLSLDKAFVTGGGVSVKEIDPKKMASKKMEGLYFCGEILDIH GYTGGYNITSALVTGRLAGLNAGQYARS*" /label="ytfP CDS" gene 2581781..2583043 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /label="ytfP gene" S_feature 2583044..2583142 /Source="Nicolas_S_feature" /locus_tag="new_3076630_3076728" /HighExp="LBGstat, Lbstat, M0t90, T2.30H, T1.0H, T0.30H, BC, T2.0H, T1.30H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1152" promotor_-35 2583116..2583122 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2583138..2583156 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2583144..2583231 /Source="Nicolas_S_feature" /locus_tag="new_3076730_3076817" /HighExp="Etha, LBGstat, Salt, M9-stat, Lbstat, LBGtran, Sw, C30, Gly, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1153" upshifts 2583144 /Source="Nicolas_upshifts" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2583232..2584770 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14996799, 15849754, 16850406, 8752321, 9925583" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14996799, 15849754, 16850406, 8752321, 9925583; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine transporter" /protein_id="NP_390885.1" /db_xref="EnsemblGenomes-Gn:BSU30070" /db_xref="EnsemblGenomes-Tr:CAB14985" /db_xref="GOA:P54417" /db_xref="InterPro:IPR000060" /db_xref="InterPro:IPR018093" /db_xref="SubtiList:BG11958" /db_xref="UniProtKB/Swiss-Prot:P54417" /translation="MLKHISSVFWIVIAITAAAVLWGVISPDSLQNVSQSAQAFITDS FGWYYLLVVSLFVGFCLFLIFSPIGKIKLGKPDEKPEFGLLSWFAMLFSAGMGIGLVF YGAAEPISHYAISSPSGETETPQAFRDALRYTFFHWGLHAWAIYAIVALCIAYFQFRK GAPGLISSTLSPILGDKVNGPIGKAIDCIAVFATVVGVSTSLGLGATQINGGLNYLFG IPNAFIVQLVLIIIVTVLFLLSAWSGLGKGIKYLSNTNMVLAGLLMLFMLVVGPTVLI MNSFTDSIGQYIQNIVQMSFRLTPNDPEKREWINSWTIFYWAWWISWSPFVGIFIARV SRGRTIREFLIGVLVTPCILTFLWFSIFGVSAMDLQQKGAFNVAKLSTETMLFGTLDH YPLTMVTSILALILIAVFFITSADSATFVLGMQTSYGSLNPANSVKLSWGIIQSAMAA VLLYSGGLAALQNTAILAALPFSIVILLMIASLYQSLSKERREIKKAEKLDKPRSPRV KKAY*" /label="opuD CDS" gene 2583232..2584770 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /label="opuD gene" downshifts 2584750 /Source="Nicolas_upshifts" /id="D1552" /incds=0 /nref=231 /ntot=263 /MaxReadThrough="2.0688" /MaxDrop="6.06429" /score="27.1497809" /energy="-16.3" /TU="NA" /idTUdmin="U2336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2584807..2584989) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8990290" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390886.1" /db_xref="EnsemblGenomes-Gn:BSU30080" /db_xref="EnsemblGenomes-Tr:CAB14986" /db_xref="GOA:P94496" /db_xref="InterPro:IPR020296" /db_xref="SubtiList:BG12339" /db_xref="UniProtKB/Swiss-Prot:P94496" /translation="MLKVAVFDEEHEKDLQTEINSFLKGISEEQLIDIKYTVSAACDP DGEQLYCFSALILYRK*" /label="yteV CDS" gene complement(2584807..2584989) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /label="yteV gene" downshifts complement(2584826) /Source="Nicolas_upshifts" /id="D1553" /incds=0 /nref=10 /ntot=61 /MaxReadThrough="0.597819999999999" /MaxDrop="4.78152" /score="32.507978" /energy="-16.3" /TU="NA" /idTUdmin="U2338" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2585004..2585022) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2585024) /Source="Nicolas_upshifts" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2585038..2585043) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2585057..2585725) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme for rhamnogalaturonan degradation" /protein_id="NP_390887.1" /db_xref="EnsemblGenomes-Gn:BSU30090" /db_xref="EnsemblGenomes-Tr:CAB14987" /db_xref="GOA:O34378" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG13846" /db_xref="UniProtKB/Swiss-Prot:O34378" /translation="MEHDGSLGRMLRFCEWIMRFAYTNLLWLFFTLLGLGVFGIMPAT AALFAVMRKWIQGQDNVPVLKTFWQEYKGEFFRSNLLGAVLALIGVIIYIDLALIYPS HFLLHILRFAIMIFGFLFVSMLFYVFPLLVHFDWKKRLYVKFSLLLSVAYLQYTLTML ALTVALFFLLAYLPGIVPFFSVSLISYCHMRIVYAVLLKVEQHGGEPQRKSHIRKAFY PETR*" /label="rmgU CDS" gene complement(2585057..2585725) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /label="rmgU gene" CDS complement(2585747..2587033) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase of rhamnogalaturonan degradation" /protein_id="NP_390888.1" /db_xref="EnsemblGenomes-Gn:BSU30100" /db_xref="EnsemblGenomes-Tr:CAB14988" /db_xref="GOA:O34371" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13845" /db_xref="UniProtKB/Swiss-Prot:O34371" /translation="MKNIVFCGLSSRAFSMFIKPLMERFSTHYEITGLLDADPKRFAV CKKKFPELAHVPEFSEDAFDEMMRVSKPDIVIVAGRDDTHVAYIVKSLQWNTDVITEK PMVTTVQDANRVLEAEAKSEGKVTVAFNYRYSPFHRKIKEMILDGKIGRVTSVDLNWY IDTYHGASYFKRWNRSRQFSGGLSVHKSTHHFDLVNWWLGQNPEEVFAYGALNYYGPD SEWNPLPEEDGRFCGTCRVKEKCHYYSRWHPRSSKASIKDDHLEAGDQSSLYTAYRPD ACIFDEEIDIEDTYVAAVKYDGGALLSYSIIFSAPYEGYRLTINGTKGRIESNEFHEP SRIPFAFPEQTIEYYPLFESKQTIQVVKNEGGHGGGDPLLLEDLFLGKDPLRRYDILA GAEAGAYSIAVGEGMWRSVAEKKPIGMKELFQMQNV*" /label="rmgT CDS" gene complement(2585747..2587033) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /label="rmgT gene" CDS complement(2587045..2587548) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17449691, 23504016; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein required for rhamnogalaturonan transport and degradation" /protein_id="NP_390889.2" /db_xref="EnsemblGenomes-Gn:BSU30110" /db_xref="EnsemblGenomes-Tr:CAB14989" /db_xref="GOA:C0SP80" /db_xref="SubtiList:BG13844" /db_xref="UniProtKB/Swiss-Prot:C0SP80" /translation="MTKRIRTALCVIVSVLFLASCSSRPDGMHVILFSDMQAGVQEKI KKAAEQNAGKVDIFPAFQEKLLTEITAHEGDVFIVPEDMFQAYDDPENFQPLNGLPPE KTSPYTTVNKKTGEKTIYAVQIEKGKKQLNGYSFQLNRDMAAFIPVYAEKTEEALQLI SQLTEAR*" /label="rmgS CDS" gene complement(2587045..2587548) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /label="rmgS gene" CDS complement(2587545..2588666) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /EC_number="3.2.1.172" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15148314, 15906318, 16781735, 16870154, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15148314, 15906318, 16781735, 16870154, 17449691, 23504016; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="unsaturated rhamnogalacturonyl hydrolase" /protein_id="NP_390890.3" /db_xref="EnsemblGenomes-Gn:BSU30120" /db_xref="EnsemblGenomes-Tr:CAB14990" /db_xref="GOA:O34559" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="PDB:1NC5" /db_xref="PDB:2D8L" /db_xref="PDB:2GH4" /db_xref="SubtiList:BG13843" /db_xref="UniProtKB/Swiss-Prot:O34559" /translation="MGSMDQSIAVKSPLTYAEALANTIMNTYTVEELPPANRWHYHQG VFLCGVLRLWEATGEKRYFEYAKAYADLLIDDNGNLLFRRDELDAIQAGLILFPLYEQ TKDERYVKAAKRLRSLYGTLNRTSEGGFWHKDGYPYQMWLDGLYMGGPFALKYANLKQ ETELFDQVVLQESLMRKHTKDAKTGLFYHAWDEAKKMPWANEETGCSPEFWARSIGWY VMSLADMIEELPKKHPNRHVWKNTLQDMIKSICRYQDKETGLWYQIVDKGDRSDNWLE SSGSCLYMYAIAKGINKGYLDRAYETTLLKAYQGLIQHKTETSEDGAFLVKDICVGTS AGFYDYYVSRERSTNDLHGAGAFILAMTELEPLFRSAGK*" /label="rmgQ CDS" gene complement(2587545..2588666) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /label="rmgQ gene" CDS complement(2588674..2589639) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease for unsaturated rhamnogalacturonan" /protein_id="NP_390892.2" /db_xref="EnsemblGenomes-Gn:BSU30135" /db_xref="EnsemblGenomes-Tr:CAB14992" /db_xref="GOA:C0SPB3" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13841" /db_xref="UniProtKB/Swiss-Prot:C0SPB3" /translation="MKTAEAQAPAVDAVIFKKEKRKRLLIKLIQQKYLYLMILPGCIY FLLFKYVPMWGIVIAFQDYQPFLGILGSEWVGLKHFIRLFTEPTFFLLLKNTLVLFAL NLAIFFPVPILLALLLNEVRIALFKKFVQTLIYIPHFMSWVIVVSLSFVLLTVDGGLI NELIVFFGGEKINFLLNEEWFRPLYILQVIWREAGWSTIIYLAAITAVDPQLYEAAKM DGAGRLRQMWHITLPAIKSVIVVLLILKIGDTLELGFEHVYLLLNATNREVAEIFDTY VYTAGLKQGQFSYSTAVGVFKAAVGLILVMLANRLAKKFGEEGIY*" /label="rmgP CDS" gene complement(2588674..2589639) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /label="rmgP gene" upshifts complement(2589665) /Source="Nicolas_upshifts" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2589666..2589685) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2589700..2589707) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2589795..2589802 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2589815 /Source="Nicolas_upshifts" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2589818..2589837 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2589855..2592173 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="membrane bound transcriptional regulator (controlling rhamnogalacturonan degradation)" /protein_id="NP_390893.1" /db_xref="EnsemblGenomes-Gn:BSU30150" /db_xref="EnsemblGenomes-Tr:CAB14993" /db_xref="GOA:O32071" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG13838" /db_xref="UniProtKB/Swiss-Prot:O32071" /translation="MGGFMKRSQYKFYYKLITFFCLLSTIPVILVGLFSYEHSQKTAI SNVSEEKFDTLQQTQQSIEHILKTVDHSLTHYVSSPPLLRTLSEPLHSDQFQIYNQVN QELNYLQSFDTDLSNMTLVSYTKKWYMNNSGLYRLNTDTLHEAASAYTKQKASRSYWT LEENNHLISTKEGTAENCRYNINLIKQLPLNSTNTKGLAAASIPSCSLVKNMPGYSNA NNLFIIDEKGLIILHNNMSDVGESLHNDGFVQKVLAQTANSGQFETVIDRIHYKVTYQ KSDYNAWTYFSLVSLPELKKEAKSIGWITFAVCLILLTLSLLFSWLGSRHFYKPIRVL YESFARHGAIQEKQQPPQNEFELIEQSFKQLKDRNDDLEETMKQQATHLQQYFMVRLM LGKLTDEEVDNRFESLGLKQNWRHLALLVLQIDTLNHTPYEKKDMDLLLFAVNSLIER NIPTDKHLAPAVVDKQQATILINQSGTKEEFMAELNETARMIQEKAEAELQLSVSIGI SQPFDVLTKAKTAYAEGSEALKYRLKAENKSIIFYEDLDQKKTFKTHFPKQLQHELFD AVKAGDKEKADKCLHAILQAIFTQNTNPYQFQIAIARFLNHVIELMHVLGIELFELEE NKMLYDQIFELKTFEDTENWLKNEFIDPMTDKVNARADAQYKNISDNIIHIIHHEFES ELTLDEIARRLHYNPNYLSSIFKKEMGISFSEYVSSYRHHMAKSWLAETDMAVKDIAE KLKYKNSQNFIRSFKKLEGITPGNYRQQKRSM*" /label="rmgR CDS" gene 2589855..2592173 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /label="rmgR gene" downshifts 2592163 /Source="Nicolas_upshifts" /id="D1554" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="1.43431" /MaxDrop="3.6268" /score="-7.37324741" /energy="-10.2" /TU="NA" /idTUdmin="U2340" /TUdmin=1870 /isTUend="FALSE" /label="downshifts" CDS complement(2592214..2593710) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_390894.3" /db_xref="EnsemblGenomes-Gn:BSU30160" /db_xref="EnsemblGenomes-Tr:CAB14994" /db_xref="GOA:Q795R2" /db_xref="SubtiList:BG13836" /db_xref="UniProtKB/Swiss-Prot:Q795R2" /translation="MGNKWRVLLIVLVLALGGVLAGCKGTDQSSAEGKAGPDSKVKLS WMAILYHQQPPKDRAIKEIEKLTNTELDITWVPDAVKEDRLNAALAAGNLPQIVTIQD IKNSSVMNAFRSGMFWEIGDYIKDYPNLNKMNKLINKNVTIDGKLYGIYRERPLSRQG IVIRKDWLDNLNLKTPKTLDELYEVAKAFTEDDPDKDGKDDTFGLADRNDLIYGAFKT IGSYEGMPTDWKESGGKFTPDFMTQEYKDTMNYMKKLRDNGYMNKDFPVTSKTQQQEL FSQGKAGIYIGNMVDAVNLRDHASDKSMKLEIINRIKGPDGKERVWASGGHNGVFAFP KTSVKTEAELKRILAFFDRIAEEDVYSLMTYGIDGVHYNKGEDKTFTRKESQVKDWQT DIQPLSALIAIDKAYLKNTGDPLRTAYEELTEDNEKIIVSNPAESLYSASESERGDEL KKIIDDATYKYMIGDITESQFDKEVEKWESSGGKQIIQEYEEAFKQAK*" /label="ytcQ CDS" gene complement(2592214..2593710) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /label="ytcQ gene" downshifts complement(2592216) /Source="Nicolas_upshifts" /id="D1555" /incds=0 /nref=26 /ntot=160 /MaxReadThrough="-0.0485899999999999" /MaxDrop="5.21039" /score="6.31011081" /energy="-11.2" /TU="NA" /idTUdmin="U2341" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2593735..2594595) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390895.1" /db_xref="EnsemblGenomes-Gn:BSU30170" /db_xref="EnsemblGenomes-Tr:CAB14995" /db_xref="GOA:P53561" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11788" /db_xref="UniProtKB/Swiss-Prot:P53561" /translation="MKNRLFDMLIYGFLLMFALICVLPFIHVIAASFATVEEVVSKKF ILIPTTFSLDAYRYIFSTDIIYKSLLVSVFVTVIGTAVSMFLSSLMAYGLSRRDLIGR QPLMFLVVFTMLFSGGMIPTFLVVKSLGLLDSYWALILPTAINAFNLIILKNFFQNIP SSLEESAKIDGCNDLGIFFKIVLPLSLPAIATISLFYAVTYWNTYMTAILYLNDSAKW PIQVLLRQIVIVSSGMQGDMSEMGSGSPPPEQTIKMAVIVVATIPVLLVYPFIQKHFA KGALLGSVKG*" /label="ytcP CDS" gene complement(2593735..2594595) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /label="ytcP gene" promotor_-10 complement(2594671..2594690) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2594680) /Source="Nicolas_upshifts" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2594706..2594713) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2594802..2595563) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-dependent nucleoside-diphosphate-sugar epimerase" /protein_id="NP_390896.2" /db_xref="EnsemblGenomes-Gn:BSU30180" /db_xref="EnsemblGenomes-Tr:CAB14996" /db_xref="GOA:P53560" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11787" /db_xref="UniProtKB/Swiss-Prot:P53560" /translation="MKKVLIAGGNGVIGRLLAEGLISDYEVTVLDKDHFDGKASSIQA DAANYEELLKKIPKDTDAILNLLAVKIKYDIMDIAEFEKMTDVFYRASYYLCRAAAEL GIQKLVFASSNHVTDVYEKDGRSLLGREITTSDYPLSKNLYGVLKLTSEQIGHLFYLE NKLSVINLRIGTVVTDEMDTLHEKERTKKTLLSHPDLLSIFKAAIETNIRYGTYYAVS DNPGRPWSIESAVNELGFSPQINTAELLNEEENGA*" /label="ytbQ CDS" gene complement(2594802..2595563) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /label="ytbQ gene" downshifts complement(2594831) /Source="Nicolas_upshifts" /id="D1556" /incds=0 /nref=153 /ntot=196 /MaxReadThrough="1.18543" /MaxDrop="5.85654" /score="12.3836957" /energy="-11.1" /TU="NA" /idTUdmin="U2344" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" S_feature complement(2595564..2595639) /Source="Nicolas_S_feature" /locus_tag="new_3089150_3089225_c" /HighExp="LPh, HPh, aero, Gly, HiOs, BMM, GM-0.1, GM 10, GM 15, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1154" CDS complement(2595640..2596827) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /EC_number="1.14.14.46" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 for pimelic acid formation for biotin biosynthesis" /protein_id="NP_390897.1" /db_xref="EnsemblGenomes-Gn:BSU30190" /db_xref="EnsemblGenomes-Tr:CAB14997" /db_xref="GOA:P53554" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:3EJB" /db_xref="PDB:3EJD" /db_xref="PDB:3EJE" /db_xref="SubtiList:BG11528" /db_xref="UniProtKB/Swiss-Prot:P53554" /translation="MTIASSTASSEFLKNPYSFYDTLRAVHPIYKGSFLKYPGWYVTG YEETAAILKDARFKVRTPLPESSTKYQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTP RTTESYQPYIIETVHHLLDQVQGKKKMEVISDFAFPLASFVIANIIGVPEEDREQLKE WAASLIQTIDFTRSRKALTEGNIMAVQAMAYFKELIQKRKRHPQQDMISMLLKGREKD KLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPDLIGTAVEECL RYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITRSPNP HLSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLNLADFEWRYRPLFGFRALEELPV TFE*" /label="bioI CDS" gene complement(2595640..2596827) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /label="bioI gene" CDS complement(2596896..2597903) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /EC_number="2.8.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin synthase" /protein_id="NP_390898.1" /db_xref="EnsemblGenomes-Gn:BSU30200" /db_xref="EnsemblGenomes-Tr:CAB14998" /db_xref="GOA:P53557" /db_xref="InterPro:IPR002684" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010722" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024177" /db_xref="SubtiList:BG11525" /db_xref="UniProtKB/Swiss-Prot:P53557" /translation="MNQWMELADRVLAGAEVTDEEALSILHCPDEDILLLMHGAFHIR KHFYGKKVKLNMIMNAKSGLCPENCGYCSQSAISKAPIESYRMVNKETLLEGAKRAHD LNIGTYCIVASGRGPSNREVDQVVDAVQEIKETYGLKICACLGLLKPEQAKRLKDAGV DRYNHNLNTSQRNHSNITTSHTYDDRVNTVEIAKESGLSPCSGAIIGMKETKQDVIDI AKSLKALDADSIPVNFLHAIDGTPLEGVNELNPLYCLKVLALFRFINPSKEIRISGGR EVNLRTLQPLGLYAANSIFVGDYLTTAGQEETEDHKMLSDLGFEVESVEEMKASLSAK S*" /label="bioB CDS" gene complement(2596896..2597903) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /label="bioB gene" CDS complement(2597906..2598601) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /EC_number="6.3.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242, 20565114" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242, 20565114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dethiobiotin synthetase" /protein_id="NP_390899.1" /db_xref="EnsemblGenomes-Gn:BSU30210" /db_xref="EnsemblGenomes-Tr:CAB14999" /db_xref="GOA:P53558" /db_xref="InterPro:IPR004472" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11526" /db_xref="UniProtKB/Swiss-Prot:P53558" /translation="MRGFFVTGTDTEVGKTVISSGLAALLKDNNRHVGVYKPFLSGIS RHHPDSDTSLLKDMSQTSLSHEDITPFAFKAPLAPYVAGKLEGKTVTMEEVLSHWGRI REKHECFIVEGAGGISVPLGEDYLVSHVIKALQLPMIIVARPRLGTINHTFLTVKYAE SMGLPIAGIIINGISDSPDEDEKTNPEMIERLCGVPILGVTPKLANVTKETVLHMVKD HINLSLLMNQVGV*" /label="bioD CDS" gene complement(2597906..2598601) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /label="bioD gene" CDS complement(2598598..2599767) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11322938, 11717296, 12368242, 15056910, 16557306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11322938, 11717296, 12368242, 15056910, 16557306; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="8-amino-7-oxononanoate synthase (pimeloyl-CoA-dependent)" /protein_id="NP_390900.1" /db_xref="EnsemblGenomes-Gn:BSU30220" /db_xref="EnsemblGenomes-Tr:CAB15000" /db_xref="GOA:P53556" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11527" /db_xref="UniProtKB/Swiss-Prot:P53556" /translation="MKIDSWLNERLDRMKEAGVHRNLRSMDGAPVPERNIDGENQTVW SSNNYLGLASDRRLIDAAQTALQQFGTGSSGSRLTTGNSVWHEKLEKKIASFKLTEAA LLFSSGYLANVGVLSSLPEKEDVILSDQLNHASMIDGCRLSKADTVVYRHIDMNDLEN KLNETQRYQRRFIVTDGVFSMDGTIAPLDQIISLAKRYHAFVVVDDAHATGVLGDSGQ GTSEYFGVCPDIVIGTLSKAVGAEGGFAAGSAVFIDFLLNHARTFIFQTAIPPASCAA AHEAFNIIEASREKRQLLFSYISMIRTSLKNMGYVVKGDHTPIIPVVIGDAHKTVLFA EKLQGKGIYAPAIRPPTVAPGESRIRITITSDHSMGDIDHLLQTFHSIGKELHII*" /label="bioFC CDS" gene complement(2598598..2599767) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /label="bioFC gene" promotor_-35 2598634..2598641 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2598656..2598675 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2598674 /Source="Nicolas_upshifts" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2599757..2601103) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /EC_number="2.6.1.105" /function="4.1: Biotin" /experiment="publication(s) with functional evidences, PMID:15880481, 20565114, 21437340" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15880481, 20565114, 21437340; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lysine-8-amino-7-oxononanoate aminotransferase" /protein_id="NP_390901.1" /db_xref="EnsemblGenomes-Gn:BSU30230" /db_xref="EnsemblGenomes-Tr:CAB15001" /db_xref="GOA:P53555" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR005815" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3DOD" /db_xref="PDB:3DRD" /db_xref="PDB:3DU4" /db_xref="SubtiList:BG11524" /db_xref="UniProtKB/Swiss-Prot:P53555" /translation="MTHDLIEKSKKHLWLPFTQMKDYDENPLIIESGTGIKVKDINGK EYYDGFSSVWLNVHGHRKKELDDAIKKQLGKIAHSTLLGMTNVPATQLAETLIDISPK KLTRVFYSDSGAEAMEIALKMAFQYWKNIGKPEKQKFIAMKNGYHGDTIGAVSVGSIE LFHHVYGPLMFESYKAPIPYVYRSESGDPDECRDQCLRELAQLLEEHHEEIAALSIES MVQGASGMIVMPEGYLAGVRELCTTYDVLMIVDEVATGFGRTGKMFACEHENVQPDLM AAGKGITGGYLPIAVTFATEDIYKAFYDDYENLKTFFHGHSYTGNQLGCAVALENLAL FESENIVEQVAEKSKKLHFLLQDLHALPHVGDIRQLGFMCGAELVRSKETKEPYPADR RIGYKVSLKMRELGMLTRPLGDVIAFLPPLASTAEELSEMVAIMKQAIHEVTSLED*" /label="bioK CDS" gene complement(2599757..2601103) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /label="bioK gene" promotor_-35 2600173..2600177 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2600192 /Source="Nicolas_upshifts" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2600193..2600211 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2601093..2601869) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /EC_number="6.2.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11368323, 11717296, 21437340, 28196402, 29054876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11368323, 11717296, 21437340, 28196402, 29054876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-carboxyhexanoate-CoA ligase (pimeloyl-CoA synthase)" /protein_id="NP_390902.3" /db_xref="EnsemblGenomes-Gn:BSU30240" /db_xref="EnsemblGenomes-Tr:CAB15002" /db_xref="GOA:P53559" /db_xref="InterPro:IPR005499" /db_xref="PDB:5FLG" /db_xref="PDB:5FLL" /db_xref="PDB:5FM0" /db_xref="PDB:5G1F" /db_xref="SubtiList:BG11529" /db_xref="UniProtKB/Swiss-Prot:P53559" /translation="MQEETFYSVRMRASMNGSHEDGGKHISGGERLIPFHEMKHTVNA LLEKGLSHSRGKPDFMQIQFEEVHESIKTIQPLPVHTNEVSCPEEGQKLARLLLEKEG VSRDVIEKAYEQIPEWSDVRGAVLFDIHTGKRMDQTKEKGVRVSRMDWPDANFEKWAL HSHVPAHSRIKEALALASKVSRHPAVVAELCWSDDPDYITGYVAGKKMGYQRITAMKE YGTEEGCRVFFIDGSNDVNTYIHDLEKQPILIEWEEDHDS*" /label="bioW CDS" gene complement(2601093..2601869) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /label="bioW gene" S_feature complement(2601870..2601962) /Source="Nicolas_S_feature" /locus_tag="new_3095456_3095548_c" /HighExp="T-5.40H, GM 60, LPh, GM 25, HPh, MG 120, M9-exp, BMM, GM 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1155" promotor_-10 complement(2601948..2601967) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2601962) /Source="Nicolas_upshifts" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2601982..2601989) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2602079..2602978) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390903.1" /db_xref="EnsemblGenomes-Gn:BSU30250" /db_xref="EnsemblGenomes-Tr:CAB15003" /db_xref="GOA:O34973" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11786" /db_xref="UniProtKB/Swiss-Prot:O34973" /translation="MRAERRKQLFRLLGDLPDRRPISVETLRIEEREENIVETLLLDL NGHEKAPAYFVKPKKTEGPCPAVLFQHSHGGQYDRGKSELIEGADYLKTPSFSDELTS LGYGVLAIDHWGFGDRRGKAESEIFKEMLLTGKVMWGMMIYDSLSALDYMQSRSDVQP DRIGTIGMSMGGLMAWWTAALDDRIKVCVDLCSQVDHHVLIKTQNLDRHGFYYYVPSL AKHFSASEIQSLIAPRPHLSLVGVHDRLTPAEGVDKIEKELTAVYAGQGAADCYRVVR SASGHFETAVIRHEAVRFLQKWL*" /label="ytaP CDS" gene complement(2602079..2602978) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /label="ytaP gene" promotor_-10 complement(2603001..2603019) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2603018) /Source="Nicolas_upshifts" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2603030..2603038) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2603108..2603115 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2603131..2603150 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2603137 /Source="Nicolas_upshifts" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="upshifts" CDS 2603196..2604230 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12847288; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_390904.1" /db_xref="EnsemblGenomes-Gn:BSU30260" /db_xref="EnsemblGenomes-Tr:CAB15004" /db_xref="GOA:O34829" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12626" /db_xref="UniProtKB/Swiss-Prot:O34829" /translation="MVRIKDIALKAKVSSATVSRILNEDESLSVAGETRQRVINIAEE LGYQTVAKRRKSRGQKQRAQPLIGVLSCLSPDQERQDPYFSSIRKGIEKECFEQEIFI TNSIHLGSFQEHIFRELDGVIVIGRVHDEAVKHISGRLEHAVFINHSPDPQAYDSIGI DFESASRQAIDHLFDLGYKRLGYIGGQEKEHTLKDGQSIRRTIEDKRLTAFLESAAPQ PEHVLIGEYSMREGYRLMKKAIDQGHLPEAFFIASDSMAIGALKALQEAGLQVPRDTA IVSFNGIEEAEFASTPLTTVKVYTEEMGRTGVKLLLDRLNGRTLPQHVTLPTTLIVRQ SCGCTAKEVT*" /label="msmR CDS" gene 2603196..2604230 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /label="msmR gene" promotor_-35 2604179..2604186 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2604201..2604209 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2604218 /Source="Nicolas_upshifts" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="upshifts" CDS 2604264..2605544 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8449892, 12847288, 16707683, 18954360, 28036052; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="multiple sugar-binding lipoprotein" /protein_id="NP_390905.1" /db_xref="EnsemblGenomes-Gn:BSU30270" /db_xref="EnsemblGenomes-Tr:CAB15005" /db_xref="GOA:O34335" /db_xref="InterPro:IPR006059" /db_xref="PDB:4R6H" /db_xref="SubtiList:BG12625" /db_xref="UniProtKB/Swiss-Prot:O34335" /translation="MKHTFVLFLSLILLVLPGCSAEKSSADTAKKTLTIYSTMSTDSE RDTFRKLAAAFEKEHSDIHVSLHFPGNDYENMMRVRMAANDLPDLFDTHGWGKIRYGE YTADLRDMKWTQDLDPNLNSILKNKSGKVYAYPINQAKDGLAYNRNILDRYGIAPPET MDDFIKALRTIKEKSKGSIVPFWFAGYDKSSFAQYYDQFATPLLITDPAHNEKKQLIN GTFQWSKFTYLSEILKQMQKEKLINIDAVTAKKSQLIELMAQNKIAFTMQGGTLGQDV AQINPNVKVGIIPTPAIHPGDDPIWIGGERYTLAAWKDSPQLKEAKDFIAFMARPANA KQMAEATSLPSGLTNVKADIFYANDYEYYQDVKVEPYFDRLYLPNGMWDVLGTVGQEL AADILAPQDISQKLGREYKRLREQSETQGAENNE*" /label="msmE CDS" gene 2604264..2605544 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /label="msmE gene" CDS 2605537..2606448 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 12847288, 15849754, 16707683, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="carbohydrate ABC transporter (permease)" /protein_id="NP_390906.1" /db_xref="EnsemblGenomes-Gn:BSU30280" /db_xref="EnsemblGenomes-Tr:CAB15006" /db_xref="GOA:O34706" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12565" /db_xref="UniProtKB/Swiss-Prot:O34706" /translation="MSEIARDVHVKQVKPKKQSSLWWMYIPALLSVLVFMIYPFVKGT LITFTNWNGFSQVYQWVGFAQYERLFSDPDTWHILKNTLHYGLGSTFFQNVVGLLYAL LLNQSIKTKAVTRTIVYLPVMISPLIMGYIWYFFFSYDGGALNDLLGVFGISPINALA SPSLNPWIIVMINTYQYVGIAMVVYLAGLQSIPKDYYEAAQMDGAKQGQQFFTITLPL LMPSITINIVINIIGGLKLFDVIIALTAGGPGNASQSMSTFMYDLYFKRQDAGYAATQ GIFMAFVILIISFCALAYFKRKETEMS*" /label="msmF CDS" gene 2605537..2606448 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /label="msmF gene" CDS 2606445..2607275 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 15849754, 16707683, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="maltose and multiple sugars ABC transporter (permease)" /protein_id="NP_390907.1" /db_xref="EnsemblGenomes-Gn:BSU30290" /db_xref="EnsemblGenomes-Tr:CAB15007" /db_xref="GOA:O34518" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12564" /db_xref="UniProtKB/Swiss-Prot:O34518" /translation="MRAARTKSMRIITLLAAIVACAHFIPFYILLTTSLKAKGDYSSK WIFPADISFHNFSEAWERASLGNSFINTMIITGFSALLLIIFGSLAAYPLARRETKLN KAVFALLISIMIIPPLTSMVPLYRMVVDAGMVNTHAIAIFINTAAYMPLTVFLYSGFI RSTIPKELVEAARIDGAGMLKIFFTIVFPLLKPITATICIISCVFIWNDYQFAIFFLQ DQKVQTLTVAMAGFFGENANNLHLVAAAALMAMLPMVVLFLALQKYFIAGLSSGAVKG *" /label="msmG CDS" gene 2606445..2607275 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /label="msmG gene" promotor_-35 2607248..2607252 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2607268..2607287 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2607276 /Source="Nicolas_upshifts" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2607295..2608593 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /EC_number="3.2.1.22" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12847288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-D-galactoside galactohydrolase" /protein_id="NP_390908.1" /db_xref="EnsemblGenomes-Gn:BSU30300" /db_xref="EnsemblGenomes-Tr:CAB15008" /db_xref="GOA:O34645" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12615" /db_xref="UniProtKB/Swiss-Prot:O34645" /translation="MKKITFIGAGSTIFAKNVLGDCLLTEALNGFEFALYDIDPKRLQ ESQLMLENLRDRYNPSVAINSYDDRKLALQNAGYVINAIQVGGYKPSTVIDFEIPKRY GLRQTIADTVGIGGIFRSLRTIPVLFDIAKDMEEMCPDAWFLNYTNPMATLTGAMLRY TNIKTIGLCHSVQVCTKDLFKALGMEHDGIEERIAGINHMAWLLEVKKDGTDLYPEIK RRAKEKQKTKHHDMVRFELMDKFGYYVTESSEHNAEYHPYFIKRNYPELISELQIPLD EYPRRCVKQIENWEKMRDDIVNNKNLTHERSKEYGSRIIEAMETNEPFTFGGNVLNTG LITNLPSKAVVEVTCVADRKKITPCFAGELPEQLAALNRTNINTQLMTIEAAVTRKKE AVYQAAMLDPHTSAELSMKDIISMCDDLFAAHGDWLPEYK*" /label="melA CDS" gene 2607295..2608593 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /label="melA gene" downshifts 2608574 /Source="Nicolas_upshifts" /id="D1557" /incds=0 /nref=12 /ntot=55 /MaxReadThrough="3.99614" /MaxDrop="3.96455" /score="26.0469828" /energy="-11.9" /TU="NA" /idTUdmin="U2346" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2608615..2608926) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /EC_number="2.8.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390909.2" /db_xref="EnsemblGenomes-Gn:BSU30310" /db_xref="EnsemblGenomes-Tr:CAB15009" /db_xref="GOA:O32072" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG13932" /db_xref="UniProtKB/Swiss-Prot:O32072" /translation="MEIKEISTAALKEKIEADEELYLIDVREDEEVAEGMIPQAVHIR MGDIPEKMETLDKDKEYVFICRSGMRSMNVCKYLDEQGFKTVNVEGGMMAWEGETKPK N*" /label="ytwF CDS" gene complement(2608615..2608926) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /label="ytwF gene" downshifts complement(2608626) /Source="Nicolas_upshifts" /id="D1558" /incds=0 /nref=84 /ntot=254 /MaxReadThrough="2.71726" /MaxDrop="5.77228" /score="23.1306393" /energy="-11.9" /TU="NA" /idTUdmin="U2349" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2608950..2608969) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2608958) /Source="Nicolas_upshifts" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2608984..2608991) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2608992 /Source="Nicolas_upshifts" /id="D1559" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="0.749090000000001" /MaxDrop="4.59307" /score="20.1681452" /energy="-11.2" /TU="NA" /idTUdmin="U2346" /TUdmin=418 /isTUend="FALSE" /label="downshifts" CDS complement(2609043..2611457) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /EC_number="6.1.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1317842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="leucyl-tRNA synthetase" /protein_id="NP_390910.1" /db_xref="EnsemblGenomes-Gn:BSU30320" /db_xref="EnsemblGenomes-Tr:CAB15010" /db_xref="GOA:P36430" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002302" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR025709" /db_xref="SubtiList:BG10676" /db_xref="UniProtKB/Swiss-Prot:P36430" /translation="MSFQHKEIEKKWQTYWLENKTFATLDNNEKQKFYALDMFPYPSG AGLHVGHPEGYTATDILSRMKRMQGYDVLHPMGWDAFGLPAEQYALDTGNDPAVFTKQ NIDNFRRQIQALGFSYDWDREINTTDPEYYKWTQWIFLKLYEKGLAYVDEVPVNWCPA LGTVLANEEVIDGKSERGGHPVERRPMKQWMLKITAYADRLLEDLEELDWPESIKDMQ RNWIGRSEGAHVHFAIDGHDDSFTVFTTRPDTLFGATYTVLAPEHALVENITTAEQKE AVEAYIKEIQSKSDLERTDLAKTKTGVFTGAYAINPVNGEKLPIWIADYVLASYGTGA VMAVPGHDERDFEFAKTFGLPVKEVVKGGNVEEAAYTGDGEHVNSDFLNGLHKQEAIE KVIAWLEETKNGEKKVTYRLRDWLFSRQRYWGEPIPVIHWEDGTSTAVPEEELPLILP KTDEIKPSGTGESPLANIKEWVEVTDPETGKKGRRETNTMPQWAGSCWYFLRYIDPHN PDQLASPEKLEKWLPVDMYIGGAEHAVLHLLYARFWHKFLYDIGVVPTKEPFQKLYNQ GMILGENNEKMSKSKGNVVNPDEIVASHGADTLRLYEMFMGPLDASIAWSESGLDGAR RFLDRVWRLFIEDSGELNGKIVEGAGETLERVYHETVMKVTDHYEGLRFNTGISQLMV FINEAYKATELPKEYMEGFVKLLSPVAPHLAEELWEKLGHSGTIAYEAWPVYDETKLV DDEVEIVVQLNGKVKAKLQVPADATKEQLEQLAQADEKVKEQLEGKTIRKIIAVPGKL VNIVAN*" /label="leuS CDS" gene complement(2609043..2611457) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /label="leuS gene" downshifts complement(2609047) /Source="Nicolas_upshifts" /id="D1560" /incds=0 /nref=115 /ntot=224 /MaxReadThrough="3.2803" /MaxDrop="4.46738" /score="33.3300042" /energy="-11.2" /TU="U2350" /idTUdmin="U2350" /TUdmin="-67" /isTUend="FALSE" /label="downshifts" S_feature complement(2611458..2611553) /Source="Nicolas_S_feature" /locus_tag="new_3105044_3105139_c" /HighExp="G150, G180, G135, LBGexp, HPh, LBGtran, Paraq, Lbexp, H2O2, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.989" /label="S1156" misc_RNA complement(2611567..2611781) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /product="T-box riboswitch specific of leucine tRNA ligase" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201, 27169680; Product type n: RNA" /function="16.3: Control" /label="tboL RNA" gene complement(2611567..2611781) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /label="tboL gene" downshifts complement(2611598) /Source="Nicolas_upshifts" /id="D1561" /incds=0 /nref=8 /ntot=38 /MaxReadThrough="6.86098" /MaxDrop="4.90189" /score="40.6873438" /energy="-16.7" /TU="U2350" /idTUdmin="U2352" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2611793..2611812) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2611814) /Source="Nicolas_upshifts" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2611818..2611823 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2611827..2611832) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2611839..2611857 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2611852..2612292 /Source="Nicolas_S_feature" /locus_tag="new_3105438_3105878" /HighExp="S4, S5, S3, S8, S7, S6, T5.0H, LoTm, C30, M9-stat" /AntisenseName="ytvB" /AntisenseCor="0.57398798861917499" /AntisenseRegPval="-24.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1157" upshifts 2611852 /Source="Nicolas_upshifts" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2611884..2612219) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16923906; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein" /protein_id="NP_390911.3" /db_xref="EnsemblGenomes-Gn:BSU30330" /db_xref="EnsemblGenomes-Tr:CAB15011" /db_xref="GOA:O34881" /db_xref="InterPro:IPR025353" /db_xref="SubtiList:BG13929" /db_xref="UniProtKB/Swiss-Prot:O34881" /translation="MKMLHQVLIACVIGGIMGILGHVKKRGRLEKPRMTKRFIYLGFL EDWFIGMTASILLVLSADPDSGIQLVILSIISGYGGEAVLRSFDFVRELNSGGEPAES KRQTKTPPE*" /label="ytvB CDS" gene complement(2611884..2612219) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /label="ytvB gene" S_feature complement(2612214..2612478) /Source="Nicolas_S_feature" /locus_tag="new_3105800_3106064_c" /HighExp="S6, S8, S7, Etha, S5, M9-stat, B60, BT, B36, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1158" promotor_-10 complement(2612463..2612482) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-10" upshifts complement(2612478) /Source="Nicolas_upshifts" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="upshifts" promotor_-35 complement(2612497..2612504) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-35" promotor_-35 2612517..2612524 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2612538..2612557 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2612554 /Source="Nicolas_upshifts" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2612556..2612623 /Source="Nicolas_S_feature" /locus_tag="new_3106142_3106209" /HighExp="M40t90, Etha, dia5, HiOs, dia15, H2O2, BC, Diami, M0t90, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1159" CDS 2612624..2613409 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="blue light GTP-binding receptor" /protein_id="NP_390912.1" /db_xref="EnsemblGenomes-Gn:BSU30340" /db_xref="EnsemblGenomes-Tr:CAB15012" /db_xref="GOA:O34627" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036513" /db_xref="PDB:1IUM" /db_xref="PDB:2MWG" /db_xref="PDB:2PR5" /db_xref="PDB:2PR6" /db_xref="PDB:4GCZ" /db_xref="SubtiList:BG13928" /db_xref="UniProtKB/Swiss-Prot:O34627" /translation="MASFQSFGIPGQLEVIKKALDHVRVGVVITDPALEDNPIVYVNQ GFVQMTGYETEEILGKNCRFLQGKHTDPAEVDNIRTALQNKEPVTVQIQNYKKDGTMF WNELNIDPMEIEDKTYFVGIQNDITKQKEYEKLLEDSLTEITALSTPIVPIRNGISAL PLVGNLTEERFNSIVCTLTNILSTSKDDYLIIDLSGLAQVNEQTADQIFKLSHLLKLT GTELIITGIKPELAMKMNKLDANFSSLKTYSNVKDAVKVLPIM*" /label="blrA CDS" gene 2612624..2613409 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /label="blrA gene" S_feature 2613410..2613466 /Source="Nicolas_S_feature" /locus_tag="new_3106996_3107052" /HighExp="Sw, M40t90, BC, Etha, dia5, dia15, H2O2, Mt0, M0t90, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1160" CDS complement(2613646..2614839) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390913.1" /db_xref="EnsemblGenomes-Gn:BSU30350" /db_xref="EnsemblGenomes-Tr:CAB15013" /db_xref="GOA:O34546" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13925" /db_xref="UniProtKB/Swiss-Prot:O34546" /translation="MPRALKILVIGMFINVTGASFLWPLNTIYIHNHLGKSLTVAGLV LMLNSGASVAGNLCGGFLFDKIGGFKSIMLGIAITLASLMGLVFFHDWPAYIVLLTIV GFGSGVVFPASYAMAGSVWPEGGRKAFNAIYVAQNAGVAVGSALGGVVASFSFSYVFL ANAVLYLIFFFIVYFGFRNIQTGDASQTSVLDYDAVNSKAKFAALIILSGGYVLGWLA YSQWSTTIASYTQSIGISLSLYSVLWTVNGILIVLGQPLVSFVVKKWAESLKAQMVIG FIIFIVSFSMLLTAKQFPMFLAAMVILTIGEMLVWPAVPTIANQLAPKGKEGFYQGFV NSAATGGRMIGPLFGGVLVDHYGIRALVLSLLVLLLISIATTLLYDKRIKSAKETNKQ ASISS*" /label="yttB CDS" gene complement(2613646..2614839) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /label="yttB gene" downshifts complement(2613666) /Source="Nicolas_upshifts" /id="D1562" /incds=0 /nref=5 /ntot=47 /MaxReadThrough="2.03991" /MaxDrop="3.41948" /score="-7.70376219" /energy="-9.4" /TU="NA" /idTUdmin="U2354" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2614840..2614938) /Source="Nicolas_S_feature" /locus_tag="new_3108426_3108524_c" /HighExp="dia15, LBGstat, H2O2, G180, LPhT, Paraq, Oxctl, G150, G135, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1161" promotor_-10 complement(2614919..2614938) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2614938) /Source="Nicolas_upshifts" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2614952..2614959) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2614976..2614979 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2614994..2615013 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2614998 /Source="Nicolas_upshifts" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="upshifts" CDS 2615028..2615774 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390914.2" /db_xref="EnsemblGenomes-Gn:BSU30360" /db_xref="EnsemblGenomes-Tr:CAB15014" /db_xref="GOA:Q795Q5" /db_xref="InterPro:IPR006876" /db_xref="InterPro:IPR035451" /db_xref="SubtiList:BG13924" /db_xref="UniProtKB/Swiss-Prot:Q795Q5" /translation="MEMVLAFLGFLACLIALGYGLYHLVRYVLKKEKRFSKRLFWPLF IGGLVLLFTGAALAEPDTAAANAEKKYSALNAEYKNLTKEHEELEKEYKSVSSEAKKL KDNKEDQDKLEKLKNENSDLKKTQKSLKAEIKELQENQKQLKEDAKTAKAENETLRQD KTKLENQLKETESQTASSHEDTGSSSNNTSKSDETKTADKAEGCNIKGSRNGIYHTPG STYYDRTTDPAEMFCSVEEAEAAGYRAPKR*" /label="yttA CDS" gene 2615028..2615774 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /label="yttA gene" downshifts 2615669 /Source="Nicolas_upshifts" /id="D1563" /incds=1 /nref=2 /ntot=94 /MaxReadThrough="4.11368" /MaxDrop="3.01036" /score="23.2955589" /energy="-11.6" /TU="U2355" /idTUdmin="U2355" /TUdmin="-99" /isTUend="FALSE" /label="downshifts" downshifts 2615768 /Source="Nicolas_upshifts" /id="D1564" /incds=0 /nref=31 /ntot=169 /MaxReadThrough="1.73994" /MaxDrop="4.19129" /score="23.2955589" /energy="-11.6" /TU="NA" /idTUdmin="U2355" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2615811..2617751) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14612242, 15849754, 16850406, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 15849754, 16850406, 17905982, 25118291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease)" /protein_id="NP_390915.1" /db_xref="EnsemblGenomes-Gn:BSU30370" /db_xref="EnsemblGenomes-Tr:CAB15015" /db_xref="GOA:O34741" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG13921" /db_xref="UniProtKB/Swiss-Prot:O34741" /translation="MNINQLILRNLKKNLRNYYLYVFALIFSVALYFAFVTLQYDPAI NEVKASIKGAAAIKTASILLVAVVAIFILYANTIFIKRRSKEIGLFQLIGMTKHKIFR ILSAENVMLYFGSLAIGVAAGFSISKLVLMILFKIVDVKADAKLHFSEQALVQTVIVF CGIYLLIMIMNYTFIKKQSILSLFKVTSSTEDKVKKISFFQMLIGALGIVLILTGYYV SSELFGGKFKTINELFVAMSFILGSVIIGTFLFYKGSVTFISNIIRKSKGGYLNISEV LSLSSIMFRMKSNALLLTIITTVSALAIGLLSLAYISYYSSEKTAEQNVAADFSFMNE KDAKLFENKLRESNISFVKKATPVLQANVDIANIMDGTPKEMQGDPGNMQLAVVSDKD VKGVDVAAGEAVFSGYTDLLQKIMVFKDSGVIKVKSKHETQPLKYKGLREEFLVSYTF TSGGMPAVIVDDSLFKQLDKDKDPRIQLAQSTFIGVNVKHDDQMEKANELFQQVNKKN EHLSRLDTSAAQKSLFGMVMFIVGFLGLTFLITSGCILYFKQMGESEDEKPSYTILRK LGFTQGDLIKGIRIKQMYNFGIPLVVGLFHSYFAVQSGWFLFGSEVWAPMIMVMVLYT ALYSIFGFLSVLYYKKVIKSSL*" /label="bceB CDS" gene complement(2615811..2617751) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /label="bceB gene" downshifts complement(2615822) /Source="Nicolas_upshifts" /id="D1565" /incds=0 /nref=13 /ntot=89 /MaxReadThrough="1.56566" /MaxDrop="4.45006" /score="29.4802229" /energy="-11.6" /TU="NA" /idTUdmin="U2356" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2617741..2618502) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14612242, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 17905982, 25118291; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacitracin ABC efflux transporter (ATP-binding protein)" /protein_id="NP_390916.1" /db_xref="EnsemblGenomes-Gn:BSU30380" /db_xref="EnsemblGenomes-Tr:CAB15016" /db_xref="GOA:O34697" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13920" /db_xref="UniProtKB/Swiss-Prot:O34697" /translation="MVILEANKIRKSYGNKLNKQEVLKGIDIHIEKGEFVSIMGASGS GKTTLLNVLSSIDQVSHGTIHINGNDMTAMKEKQLAEFRKQHLGFIFQDYNLLDTLTV KENILLPLSITKLSKKEANRKFEEVAKELGIYELRDKYPNEISGGQKQRTSAGRAFIH DPSIIFADEPTGALDSKSASDLLNKLSQLNQKRNATIIMVTHDPVAASYCGRVIFIKD GQMYTQLNKGGQDRQTFFQDIMKTQGVLGGVQHEH*" /label="bceA CDS" gene complement(2617741..2618502) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /label="bceA gene" misc_feature complement(2618526..2618544) /Source="Nicolas_upshift_promotors" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2618545) /Source="Nicolas_upshifts" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2618604..2619608) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase controlling resistance to antibiotics affecting the envelope [YtsA]" /protein_id="NP_390917.1" /db_xref="EnsemblGenomes-Gn:BSU30390" /db_xref="EnsemblGenomes-Tr:CAB15017" /db_xref="GOA:O35044" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13919" /db_xref="UniProtKB/Swiss-Prot:O35044" /translation="MIKAFLIERRSWIAAFLFQQALMLFIAFVDPSISFGNVLYMVYL CILFFIIFLWFRYRKETAFYKSLKTWENNLDVTAINEPETPFEAMVERSIAGQTEHLK QTAARHRLALENEKDELMAWIHEVKTPLTAMHLIIDRMEEKALKSQLSYEWLRIHLLL DQQLHQKRISFIENDLSVEFIQLQPLIFKEIKDLQSWCIQKGIGFDIQLEAKEVLSDA KWLAFIIRQLLTNAVKYSEASEIEIKSFQKGEQTQLQVKDCGRGIDPKDVPRIFDKGF TSTTDHHDQASTGMGLYLAKKAAAPLLIHIDVESEFGAGTVFTLTFPIRNQFEHVISV *" /label="bceS CDS" gene complement(2618604..2619608) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /label="bceS gene" downshifts complement(2618643) /Source="Nicolas_upshifts" /id="D1566" /incds=0 /nref=25 /ntot=187 /MaxReadThrough="2.40611" /MaxDrop="4.6482" /score="29.3236847" /energy="-13.9" /TU="NA" /idTUdmin="U2357" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2619601..2620296) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator controlling resistance to antibiotics affecting the envelope [YtsB]" /protein_id="NP_390918.1" /db_xref="EnsemblGenomes-Gn:BSU30400" /db_xref="EnsemblGenomes-Tr:CAB15018" /db_xref="GOA:O34951" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12340" /db_xref="UniProtKB/Swiss-Prot:O34951" /translation="MFKLLLIEDDESLFHEIKDRLTGWSYDVYGIQDFSQVLQEFAAV NPDCVIIDVQLPKFDGFHWCRLIRSRSNVPILFLSSRDHPADMVMSMQLGADDFIQKP FHFDVLIAKIQAMFRRVHHYNTEPSTIKTWCGAAVDAEQNLVSNDKGSVELTKNEMFI LKQLIEQKNKIVSREELIRSLWNDERFVSDNTLTVNVNRLRKKLDALQLGAYIETKVG QGYIAKEEDKFYD*" /label="bceR CDS" gene complement(2619601..2620296) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /label="bceR gene" promotor_-10 complement(2620320..2620338) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2620332) /Source="Nicolas_upshifts" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2620354..2620357) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2620393..2621703) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="metabolite permease involved in resistance to cell wall inhibitors" /protein_id="NP_390919.1" /db_xref="EnsemblGenomes-Gn:BSU30410" /db_xref="EnsemblGenomes-Tr:CAB15019" /db_xref="GOA:O35005" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13916" /db_xref="UniProtKB/Swiss-Prot:O35005" /translation="MRFKDQVHFIRRNMKKNRLRVFMTILATTMACAFLVVLSSVGFG IQKTITDMTMSQQIVTKVSVMGKEGDKPIKKADLEKYDHVRSVVERTQVYEPNKATLG NRTNESSNLIFTNMNDELKANMELEKGRVAKSENEIVVGYDFAKRLLTKKESEEYNKK IEEAKGNPEDIKEPKGYTKDILNKTIELSVSKTDSKTGDVTKTKTYDFKIVGITKKPS QDWMEDSNIFISDQFKKDFSEFLDFKGGNVETNIGVFADKFENVEQLTNDLTDDGYYV TSVTTELEGANTFFMVFKIGLIFVGCIAVIISAIGIFNTMTMAVTERTQEIGIMKAIG ASPSIIRRMFLMESAYIGILGCVIGIIISYGVSYLVNLAVPMILAATSGGDAGDLNYT FSYIPASLVIIAVVICGGVAVISGMNPARKATKTNVLTALRREL*" /label="ytrF CDS" gene complement(2620393..2621703) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /label="ytrF gene" downshifts complement(2620415) /Source="Nicolas_upshifts" /id="D1567" /incds=0 /nref=9 /ntot=170 /MaxReadThrough="4.26891" /MaxDrop="3.83905" /score="28.2472037" /energy="-13.6" /TU="U2359" /idTUdmin="U2359" /TUdmin="-1755" /isTUend="FALSE" /label="downshifts" CDS complement(2621693..2622388) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22720735, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22720735, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390920.1" /db_xref="EnsemblGenomes-Gn:BSU30420" /db_xref="EnsemblGenomes-Tr:CAB15020" /db_xref="GOA:O34392" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13915" /db_xref="UniProtKB/Swiss-Prot:O34392" /translation="MIDVQHIDHSFTIGKKGRENEVPVLKDVSLSVAKGEIACIVGRS GSGKSTLLNLISGYISPTKGRIVINGTDVTGFNEKEWAQFRLDHFGFIFQSFQLIPGL TTYENVEMPLALKGIKPSERKQKVQDMLKRVGLENHAAHYPNELSGGQQQRVSIARAL ILNPSIILADEPTGSLDSETEHEVLELIQQLNRERGITFVIITHDDEVASIGHSKFQL HDGVLKGGITVEV*" /label="ytrE CDS" gene complement(2621693..2622388) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /label="ytrE gene" CDS complement(2622403..2623380) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390921.1" /db_xref="EnsemblGenomes-Gn:BSU30430" /db_xref="EnsemblGenomes-Tr:CAB15021" /db_xref="GOA:O34953" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13914" /db_xref="UniProtKB/Swiss-Prot:O34953" /translation="MPDSGLLYKEWRQNKVALVITILVFILGNPLSILNMYLIYQGCV TGKENWVGPCVFSVDYLNSSFISLFWIWGVVLAVSQLGIERSKSFFDFTLSLPYTRGQ IFHAKFLTGGMVIVVPQLIGYVLSVLLIMLLKPDQAVYFHNYSLGMIIVSMLAYSLVM AGGALTGNSFAQLLVSFTVAISPFLLISLPVINLEILFGGSIDFIHGPVPKWVQYFIP IIYVDSKWAENSPYYLVIPAIMTIIFYIIGYISFVKMSNERNGYFFLWKPLNRPVQII VIIIGIMGFGYFGFTASESFAGYLIGMGTGAVIGFLISYFAIYKKMKLL*" /label="ytrD CDS" gene complement(2622403..2623380) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /label="ytrD gene" CDS complement(2623410..2624396) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390922.1" /db_xref="EnsemblGenomes-Gn:BSU30440" /db_xref="EnsemblGenomes-Tr:CAB15022" /db_xref="GOA:O34898" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13913" /db_xref="UniProtKB/Swiss-Prot:O34898" /translation="MVDRGLLYREWKQNQVVILLSIAFLVLANPLSIVNTYLSYQGCL DRQDPQYCDFIVNYSISNLIDINWVPGVILAVCFLGMERSKGTMDFILSLPYNRSQIF QTKFWLGGFVIVLSQLIGFLLAWLLILVYNPEHVYFFEHSSIGVIVISFMAFSLVMAA GALTGNAFAQLLTAFSAAILPYLIIALPVGNLEVVFGANIWEIFPSPESYFSLASNLS NLVPISYVVNEWLINSKYLLLIPAVMSMLFYLIGFISFKKLPSERNGHFFLWNRLDRP VQILVMAFGILGFGLFGYYTGHSIIGYILGMIIGAVAGFFVSYFSIYKKTKV*" /label="ytrC CDS" gene complement(2623410..2624396) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /label="ytrC gene" promotor_-35 2624266..2624275 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2624282 /Source="Nicolas_upshifts" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2624288..2624303 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2624390..2625268) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390923.1" /db_xref="EnsemblGenomes-Gn:BSU30450" /db_xref="EnsemblGenomes-Tr:CAB15023" /db_xref="GOA:O34641" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13912" /db_xref="UniProtKB/Swiss-Prot:O34641" /translation="MIELRQLSKAIDGNQVLKDVSLTIEKGEIFGLLGRNGSGKTTML RLIQQIIFADSGTILFDGVEIKKHPKVKQNIIYMPVQNPFYDKYTYKQLVDILRRIYP KFDVTYANELMNRYEIPETKKYRELSTGLKKQLSLVLSFAARPALILLDEPTDGIDAV TRHDVLQLMVDEVAERDTSILITSHRLEDIERMCNRIGFLEDNSLTNVMDLDELKEEY IKIQMAFDTDVNLAIREQNIPMLDQAGVFYTVLIPKSDEEKKSFLRELKPKVWNELPV NLEEVFIAKFGGKRRW*" /label="ytrB CDS" gene complement(2624390..2625268) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /label="ytrB gene" CDS complement(2625261..2625653) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986249, 11756427, 17194626, 21856850, 28357385" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 11756427, 17194626, 21856850, 28357385; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family, cell wall antibiotics)" /protein_id="NP_390924.1" /db_xref="EnsemblGenomes-Gn:BSU30460" /db_xref="EnsemblGenomes-Tr:CAB15024" /db_xref="GOA:O34712" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13911" /db_xref="UniProtKB/Swiss-Prot:O34712" /translation="MIQIDPRSSTPIYEQIIQQMKELCLKGIMKPGDKLPSVRELATI IIANPNTVSKAYKELEREGIIETLRGRGTYISENAKTTLVEGKMTMIKEQLKQLIIDA HYAGVELEKLHEWIKEISADVKGGKKND*" /label="ytrA CDS" gene complement(2625261..2625653) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /label="ytrA gene" S_feature complement(2625654..2625898) /Source="Nicolas_S_feature" /locus_tag="new_3119240_3119484_c" /HighExp="Cold, Salt, SMMPr, MG 15, M9-tran, G180, M9-exp, M/G, MG 25, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.71885600000000005" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1162" CDS complement(2625687..2625824) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28357385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513999.1" /db_xref="EnsemblGenomes-Gn:BSU30466" /db_xref="EnsemblGenomes-Tr:CCQ48604" /db_xref="GOA:L8ECR1" /db_xref="UniProtKB/TrEMBL:L8ECR1" /translation="MKHKKRNKRNVPMLIAASVIACSFFLVLVMIGFEWQKSIIDHFY L*" /label="conserved protein of unknown function CDS" gene complement(2625687..2625824) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /label="gene" downshifts 2625822 /Source="Nicolas_upshifts" /id="D1568" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="2.62989" /MaxDrop="3.1332" /score="6.69010243" /energy="-14.4" /TU="NA" /idTUdmin="U2361" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2625893..2625912) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2625898) /Source="Nicolas_upshifts" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2625926..2625933) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2625979..2626251) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390925.1" /db_xref="EnsemblGenomes-Gn:BSU30470" /db_xref="EnsemblGenomes-Tr:CAB15025" /db_xref="InterPro:IPR019668" /db_xref="SubtiList:BG13937" /db_xref="UniProtKB/Swiss-Prot:O32073" /translation="MATRQSVDEHLQQCMQAYDYAEEQLKIASKQEHYNDQEYSDAQM QLEDAVNALNKLWLSSNDQQREQLYRMRLQLQSLQNNMILQHPLDV*" /label="ytzC CDS" gene complement(2625979..2626251) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /label="ytzC gene" downshifts complement(2625986) /Source="Nicolas_upshifts" /id="D1569" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.96566" /MaxDrop="8.4811" /score="36.3100501" /energy="-14.4" /TU="NA" /idTUdmin="U2360" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2626291..2626302) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2626295..2626303 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2626295) /Source="Nicolas_upshifts" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="upshifts" upshifts 2626306 /Source="Nicolas_upshifts" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2626317..2626323) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2626317..2626335 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2626346..2626351 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2626365..2626384 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2626372 /Source="Nicolas_upshifts" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="upshifts" CDS 2626413..2627381 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10413665; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_390926.1" /db_xref="EnsemblGenomes-Gn:BSU30480" /db_xref="EnsemblGenomes-Tr:CAB15026" /db_xref="GOA:O35008" /db_xref="InterPro:IPR005911" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032432" /db_xref="SubtiList:BG13908" /db_xref="UniProtKB/Swiss-Prot:O35008" /translation="MMQNNPFPYSNTEKRYHTLNYHLREHFGHKVFKVALDGGFDCPN RDGTVAHGGCTFCSAAGSGDFAGNRTDDLITQFHDIKNRMHEKWKDGKYIAYFQAFTN THAPVEVLREKFESVLALDDVVGISIATRPDCLPDDVVDYLAELNERTYLWVELGLQT VHERTALLINRAHDFNCYVEGVNKLRKHGIRVCSHIINGLPLEDRDMMMETAKAVADL DVQGIKIHLLHLLKGTPMVKQYEKGKLEFLSQDDYVQLVCDQLEIIPPEMIVHRITGD GPIELMIGPMWSVNKWEVLGAINKELENRGSYQGKFFQRLEEESAL*" /label="ytqA CDS" gene 2626413..2627381 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /label="ytqA gene" CDS 2627378..2627962 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24699744; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methylase" /protein_id="NP_390927.1" /db_xref="EnsemblGenomes-Gn:BSU30490" /db_xref="EnsemblGenomes-Tr:CAB15027" /db_xref="GOA:O34614" /db_xref="InterPro:IPR010719" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13909" /db_xref="UniProtKB/Swiss-Prot:O34614" /translation="MILKKILPYSKELLKMAAGEGDIVVDATMGNGHDTQFLAELVGE NGHVYAFDIQESAVANTKERLGDMYQARTTLFHKSHDKIAESLPPETHGKVAAAVFNL GYLPGGDKSITTNGSSTIKAIEQLLSIMKDEGLIVLVVYHGHPEGKAEKNDVLEFCRD LDQQTARVLTYGFINQQNDPPFIVAIEKKAQISK*" /label="ytqB CDS" gene 2627378..2627962 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /label="ytqB gene" downshifts 2627926 /Source="Nicolas_upshifts" /id="D1570" /incds=0 /nref=58 /ntot=249 /MaxReadThrough="2.35311" /MaxDrop="4.47418" /score="22.0352465" /energy="-11.9" /TU="NA" /idTUdmin="U2362" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2627952..>2628083) /gene="tbcS" /locus_tag="IIG_Bs13_pseudo_BSU_30500" /old_locus_tag="BSU_30500" /EC_number="4.2.3.130" /experiment="publication(s) with functional evidences, PMID:21627333, 24806199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21627333, 24806199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetraprenyl-beta-curcumene synthase" /protein_id="NP_390928.1" /db_xref="EnsemblGenomes-Gn:BSU30500" /db_xref="EnsemblGenomes-Tr:CAB15028" /db_xref="GOA:O34707" /db_xref="InterPro:IPR019712" /db_xref="SubtiList:BG13901" /db_xref="UniProtKB/Swiss-Prot:O34707" /modified_by="User" /translation="LAKKLIKASGKTSLFFYINGRAYRKFQKMSWMKNSKKKAQIIC* " /label="IIG_Bs13_pseudo_BSU_30500" gene complement(2627952..>2628083) /gene="tbcS" /locus_tag="IIG_Bs13_pseudo_BSU_30500" /old_locus_tag="BSU_30500" /modified_by="User" /label="IIG_Bs13_pseudo_BSU_30500" downshifts complement(2627993) /Source="Nicolas_upshifts" /id="D1571" /incds=0 /nref=35 /ntot=240 /MaxReadThrough="3.47268" /MaxDrop="4.45295" /score="16.7564664" /energy="-10.1" /TU="U2364" /idTUdmin="U2365" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" SCAR 2628086..2628087 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs13" S_feature complement(<2628087..2628102) /Source="Nicolas_S_feature" /locus_tag="new_3123442_3124021_c" /HighExp="dia15, H2O2, Diami, Salt, dia5, M0t90, Lbstat, Etha, Paraq, Lbtran" /AntisenseName="ytoA" /AntisenseCor="-0.44861767737485803" /AntisenseRegPval="-14" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1163" promotor_-10 complement(2628093..2628112) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2628102) /Source="Nicolas_upshifts" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2628104..2628238) /Source="Nicolas_S_feature" /locus_tag="new_3124023_3124157_c" /HighExp="LoTm, Cold, dia5, dia15, Diami, H2O2, S7, G135, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1164" promotor_-35 complement(2628124..2628131) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2628213..2628232) /Source="Nicolas_upshift_promotors" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2628238) /Source="Nicolas_upshifts" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2628331..2629722) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_390931.1" /db_xref="EnsemblGenomes-Gn:BSU30530" /db_xref="EnsemblGenomes-Tr:CAB15031" /db_xref="GOA:O34618" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG13891" /db_xref="UniProtKB/Swiss-Prot:O34618" /translation="MQKQKQELHRGLEERHISLMSLGAAIGVGLFLGSASAIQLAGPG ILVAYAASGLVMFFIMRALGEMAIQKPVAGSFSRYARDYLGPLAGYLTGWNYWFLWVV TCMAEITAVGIYMGFWFPDVPNWIWALSALVIMTGVNFLAVKAYGELEFWFALIKIVA ILSMIAVGLLMIIAGVGNGGIATGISNLWNNGGFFPHGLKGVLLSLQMVMFAYLGIEM IGVTAGEVKNPQKSLAKAIDTVFWRILIFYVGALFVIMSIYPWQEIGSQGSPFVLTFQ KVGIPSAAGIINFVVLTAALSSCNSGIFSTGRMLFNLAEQKEAPQAYGQLTKGGIPGK AVLASAGALLVGVLLNYVVPAKVFTWVTSIATFGAIWTWAIILLSQIKYRKSLKPEEK KQLKYKMPLFPFTSYVSLAFLAFVVILMAYSPDTRVAVIIGPIWFLILLAVYYGKGFH KKNAAAASERNIS*" /label="ytnA CDS" gene complement(2628331..2629722) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /label="ytnA gene" downshifts complement(2628339) /Source="Nicolas_upshifts" /id="D1572" /incds=0 /nref=133 /ntot=225 /MaxReadThrough="3.05784" /MaxDrop="5.43778" /score="3.82664462" /energy="-7.5" /TU="U2368" /idTUdmin="U2368" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" S_feature complement(2629723..2629857) /Source="Nicolas_S_feature" /locus_tag="new_3125642_3125776_c" /HighExp="Oxctl, Paraq, Heat, Lbexp, G150, S0, dia0, H2O2, G180, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1165" CDS complement(2629858..2631756) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /EC_number="2.4.-.-" /EC_number="6.3.5.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 21949063, 28317238" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 21949063, 28317238; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-diaminopimelic acid amidotransferase (asparagine synthetase)" /protein_id="NP_390932.1" /db_xref="EnsemblGenomes-Gn:BSU30540" /db_xref="EnsemblGenomes-Tr:CAB15032" /db_xref="GOA:P54420" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11831" /db_xref="UniProtKB/Swiss-Prot:P54420" /translation="MCGFVGVFNKHPLAQTADQEELIKQMNQMIVHRGPDSDGYFHDE HVGFGFRRLSIIDVENGGQPLSYEDETYWIIFNGEIYNYIELREELEAKGYTFNTDSD TEVLLATYRHYKEEAASKLRGMFAFLIWNKNDHVLYGARDPFGIKPLYYTTINDQVYF ASERKSLMVAQNDIEIDKEALQQYMSFQFVPEPSTLDAHVKKVEPGSQFTIRPDGDIT FKTYFKANFKPVQTEEDKLVKEVRDAIYDSVNVHMRSDVPVGSFLSGGIDSSFIVSVA KEFHPSLKTFSVGFEQQGFSEVDVAKETAAALGIENISKVISPEEYMNELPKIVWHFD DPLADPAAIPLYFVAKEAKKHVTVALSGEGADELFGGYNIYREPLSLKPFERIPSGLK KMLLHVAAVMPEGMRGKSLLERGCTPLQDRYIGNAKIFEESVKKQLLKHYNPNLSYRD VTKTYFTESSSYSDINKMQYVDIHTWMRGDILLKADKMTMANSLELRVPFLDKVVFDV ASKIPDELKTKNGTTKYLLRKAAEGIVPEHVLNRKKLGFPVPIRHWLKNEMNEWVRNI IQESQTDAYIHKDYVLQLLEDHCADKADNSRKIWTVLIFMIWHSINIEKRYMPEELSH QPKEVIFV*" /label="asnB CDS" gene complement(2629858..2631756) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /label="asnB gene" promotor_-35 2630914..2630920 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2630935..2630946 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2630947 /Source="Nicolas_upshifts" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2631757..2631880) /Source="Nicolas_S_feature" /locus_tag="new_3127676_3127799_c" /HighExp="Paraq, G135, G180, G150, Oxctl, LBGexp, BMM, dia0, Heat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.632, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1166" CDS complement(2631906..2633108) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /EC_number="2.5.1.6" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16672621, 18634909" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16672621, 18634909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine synthetase" /protein_id="NP_390933.1" /db_xref="EnsemblGenomes-Gn:BSU30550" /db_xref="EnsemblGenomes-Tr:CAB15033" /db_xref="GOA:P54419" /db_xref="InterPro:IPR002133" /db_xref="InterPro:IPR022628" /db_xref="InterPro:IPR022629" /db_xref="InterPro:IPR022630" /db_xref="InterPro:IPR022631" /db_xref="InterPro:IPR022636" /db_xref="SubtiList:BG11840" /db_xref="UniProtKB/Swiss-Prot:P54419" /translation="MSKNRRLFTSESVTEGHPDKICDQISDSILDEILKKDPNARVAC ETSVTTGLVLVSGEITTSTYVDIPKTVRQTIKEIGYTRAKYGFDAETCAVLTSIDEQS ADIAMGVDQALEAREGTMSDEEIEAIGAGDQGLMFGYACNETKELMPLPISLAHKLAR RLSEVRKEDILPYLRPDGKTQVTVEYDENNKPVRIDAIVISTQHHPEITLEQIQRNIK EHVINPVVPEELIDEETKYFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGA FSGKDATKVDRSAAYAARYVAKNIVAAELADSCEVQLAYAIGVAQPVSISINTFGSGK ASEEKLIEVVRNNFDLRPAGIIKMLDLRRPIYKQTAAYGHFGRHDVDLPWERTDKAEQ LRKEALGE*" /label="metK CDS" gene complement(2631906..2633108) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /label="metK gene" downshifts complement(2631925) /Source="Nicolas_upshifts" /id="D1573" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="7.14538" /MaxDrop="3.78097" /score="-4.044113" /energy="-12.1" /TU="U2367,U2368" /idTUdmin="U2367" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2633151..2633162) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2633157) /Source="Nicolas_upshifts" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2633159..2633275) /Source="Nicolas_S_feature" /locus_tag="new_3129078_3129194_c" /HighExp="G180, Paraq, G150, Oxctl, G135, BMM, LBGexp, HPh, MG-0.2, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1167" promotor_-35 complement(2633176..2633182) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2633276..2633414) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswG RNA" gene complement(2633276..2633414) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /label="mswG gene" downshifts 2633374 /Source="Nicolas_upshifts" /id="D1574" /incds=0 /nref=3 /ntot=20 /MaxReadThrough="1.15866" /MaxDrop="4.97875" /score="11.8729615" /energy="-16.6" /TU="NA" /idTUdmin="U2369" /TUdmin="-1841" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2633423..2633442) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-10" upshifts complement(2633438) /Source="Nicolas_upshifts" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="upshifts" promotor_-35 complement(2633459..2633463) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-35" promotor_-35 2633535..2633542 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2633554 /Source="Nicolas_upshifts" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2633556..2633575 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2633611..2635194 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /EC_number="4.1.1.49" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400158, 4146915, 15491857, 15720552, 18586936, 20933603, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoenolpyruvate carboxykinase" /protein_id="NP_390934.2" /db_xref="EnsemblGenomes-Gn:BSU30560" /db_xref="EnsemblGenomes-Tr:CAB15034" /db_xref="GOA:P54418" /db_xref="InterPro:IPR001272" /db_xref="InterPro:IPR008210" /db_xref="InterPro:IPR013035" /db_xref="InterPro:IPR015994" /db_xref="SubtiList:BG11841" /db_xref="UniProtKB/Swiss-Prot:P54418" /translation="MNSVDLTADLQALLTCPNVRHNLSAAQLTEKVLSRNEGILTSTG AVRATTGAYTGRSPKDKFIVEEESTKNKIDWGPVNQPISEEAFERLYTKVVSYLKERD ELFVFEGFAGADEKYRLPITVVNEFAWHNLFARQLFIRPEGNDKKTVEQPFTILSAPH FKADPKTDGTHSETFIIVSFEKRTILIGGTEYAGEMKKSIFSIMNFLLPERDILSMHC SANVGEKGDVALFFGLSGTGKTTLSADADRKLIGDDEHGWSDTGVFNIEGGCYAKCIH LSEEKEPQIFNAIRFGSVLENVVVDEDTREANYDDSFYTENTRAAYPIHMINNIVTPS MAGHPSAIVFLTADAFGVLPPISKLTKEQAMYHFLSGYTSKLAGTERGVTSPETTFST CFGSPFLPLPAHVYAEMLGKKIDEHGADVFLVNTGWTGGGYGTGERMKLSYTRAMVKA AIEGKLEDAEMITDDIFGLHIPAHVPGVPDHILQPENTWTNKEEYKEKAVYLANEFKE NFKKFAHTDAIAQAGGPLV*" /label="pckA CDS" gene 2633611..2635194 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /label="pckA gene" downshifts 2635183 /Source="Nicolas_upshifts" /id="D1575" /incds=0 /nref=106 /ntot=269 /MaxReadThrough="2.55056" /MaxDrop="8.3695" /score="11.8729615" /energy="-16.6" /TU="U2369" /idTUdmin="U2369" /TUdmin="-32" /isTUend="FALSE" /label="downshifts" CDS complement(2635233..2635475) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390935.1" /db_xref="EnsemblGenomes-Gn:BSU30570" /db_xref="EnsemblGenomes-Tr:CAB15035" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019699" /db_xref="PDB:2NWA" /db_xref="SubtiList:BG13882" /db_xref="UniProtKB/Swiss-Prot:O34365" /translation="MGMPVEFNTLIVTKGKEVRIDENIFTLEKDGYRVYPMEIPMDVR KTKFGEKSGTAEVQKLQWEEGRTIITYKLTSLHSVN*" /label="ytmB CDS" gene complement(2635233..2635475) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /label="ytmB gene" downshifts complement(2635247) /Source="Nicolas_upshifts" /id="D1576" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="1.2088" /MaxDrop="5.1365" /score="38.3436505" /energy="-16.6" /TU="NA" /idTUdmin="U2371" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2635527..2636300) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27899916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative esterase" /protein_id="NP_390936.1" /db_xref="EnsemblGenomes-Gn:BSU30580" /db_xref="EnsemblGenomes-Tr:CAB15036" /db_xref="GOA:O34493" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13881" /db_xref="UniProtKB/Swiss-Prot:O34493" /translation="MIVEKRRFPSPSQHVRLYTICYLSNGLRVKGLLAEPAEPGQYDG FLYLRGGIKSVGMVRPGRIIQFASQGFVVFAPFYRGNQGGEGNEDFAGEDREDAFSAF RLLQQHPNVKKDRIHIFGFSRGGIMGMLTAIEMGGQAASFVSWGGVSDMILTYEERQD LRRMMKRVIGGTPKKVPEEYQWRTPFDQVNKIQAPVLLIHGEKDQNVSIQHSYLLEEK LKQLHKPVETWYYSTFTHYFPPKENRRIVRQLTQWMKNR*" /label="ytmA CDS" gene complement(2635527..2636300) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /label="ytmA gene" S_feature complement(2636301..2636391) /Source="Nicolas_S_feature" /locus_tag="new_3132220_3132310_c" /HighExp="S8, dia15, Diami, Etha, S7, dia5, H2O2, G180, Heat, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1168" promotor_-35 2636367..2636376 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2636380..2636399) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2636388 /Source="Nicolas_upshifts" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2636389..2636408 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2636393) /Source="Nicolas_upshifts" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2636414..2636421) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2636451..2637455 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component" /protein_id="NP_390937.2" /db_xref="EnsemblGenomes-Gn:BSU30595" /db_xref="EnsemblGenomes-Tr:CAB15037" /db_xref="GOA:C0SP84" /db_xref="SubtiList:BG13873" /db_xref="UniProtKB/Swiss-Prot:C0SP84" /translation="MNRWLRLGFACVGSIFLMFALAACKQEETLTKVKVAEVTHSIFY APLYVAESKGFFKEEGLDVDVNTTWGGDKTMTSLLSNGSDIALVGSETSIYVEAQGAK DPVINFAQLTQTDGTFLVAREDVEHFDWDQLKGKTFLGQRKGGMPQMVGEYVLNKHKI DPHKDIDLIQNIDFANIANAFASGTGEYVQLFEPQASLFEKKGIGHIVASFGEESGEV PYTTFMAKQSYLKKNEDTAVKFTKAIYKAQQWVENHSAKDITDAIKDEFDDTDPDVIE TSIERYKKQHSYSPDPLLNEKEWELLQTIMDKSGELPKHIPYNQLVNKEIAEKVTSEK *" /label="ytlA CDS" gene 2636451..2637455 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /label="ytlA gene" CDS 2637468..2638250 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component, ATP-binding" /protein_id="NP_390939.1" /db_xref="EnsemblGenomes-Gn:BSU30610" /db_xref="EnsemblGenomes-Tr:CAB15039" /db_xref="GOA:O34314" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13875" /db_xref="UniProtKB/Swiss-Prot:O34314" /translation="MSFLHVDHVTHTYFSIKEKTTAVRDIHFDAEKGDFISFLGPSGC GKTTLLSIIAGLIEPSEGRVLIEGREPNQKEHNIGYMLQQDYLFPWKSIEENVLLGLK IADTLTEESKAAALGLLPEFGLIDVEKKYPKELSGGMRQRAALARTLAPNPSLLLLDE PFSALDFQTKLSLENLVFRTLKEYQKTAVLVTHDIGEAIAMSDTIFLFSNQPGTIHQI FTIPKELAAMLPFDARQEPSFQTLFQTIWKELNSLEKQQRNH*" /label="ytlC CDS" gene 2637468..2638250 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /label="ytlC gene" S_feature complement(2637472..2639020) /Source="Nicolas_S_feature" /locus_tag="new_3133391_3134939_c" /HighExp="Cold, S8, G180, H2O2, G135, Paraq, G150, S7, Oxctl, LPh" /AntisenseName="ytlC" /AntisenseCor="0.110169300738282" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1169" CDS 2638225..2639037 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease of ABC anion transporter" /protein_id="NP_390940.1" /db_xref="EnsemblGenomes-Gn:BSU30620" /db_xref="EnsemblGenomes-Tr:CAB15040" /db_xref="GOA:O34649" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13876" /db_xref="UniProtKB/Swiss-Prot:O34649" /translation="MRNSKETIDLLHEQYQFKQKKEKWKVHSFQLAIFILFFSGWEIS SRQGWIDPLIFSSPSAVWRLLLEKLGDGSLLSHIGVTLFETVLGFLLGTFMGTCLAAL LWWSNRLARILDPYLVILNAMPKVALGPILIVALGPSFISIIAMGAIISVIITTIVVY TAFQEVDENYTKVMKTFGAKKWVIFKEVILPASSPAIISTLKVNVGLSWVGVIVGEFL VSKVGLGYMIIYGFQVFNFTLVFLSLLIIAIFATLMYQGVELLEKKWTKGRT*" /label="ytlD CDS" gene 2638225..2639037 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /label="ytlD gene" downshifts 2639022 /Source="Nicolas_upshifts" /id="D1577" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="3.58734" /MaxDrop="4.596" /score="38.1379668" /energy="-12.6" /TU="U2370" /idTUdmin="U2370" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" CDS complement(2639064..2639540) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /EC_number="3.6.1.15" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576788, 16513759, 21925382, 23610407, 23610425, 27936487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576788, 16513759, 21925382, 23610407, 23610425, 27936487; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nucleoside and RNA triphosphate phosphohydrolase" /protein_id="NP_390941.1" /db_xref="EnsemblGenomes-Gn:BSU30630" /db_xref="EnsemblGenomes-Tr:CAB15041" /db_xref="GOA:O35013" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR014078" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="PDB:4JZS" /db_xref="PDB:4JZT" /db_xref="PDB:4JZU" /db_xref="PDB:4JZV" /db_xref="SubtiList:BG13869" /db_xref="UniProtKB/Swiss-Prot:O35013" /translation="MYEFKDYYQNTVQLSFDDQPFSDSPKHVWVICRFGGKWLLTEHE DRGYEFPGGKVEPMECAEEAALREVKEETGARVKSLKYLGQYKVLGKEKVIVKNIYFA DIEKLEKQADYFETKGPVLFHELPENLSRNKKFSFIMKDSVLPISLKKLKESGWIE*" /label="rppG CDS" gene complement(2639064..2639540) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /label="rppG gene" downshifts complement(2639065) /Source="Nicolas_upshifts" /id="D1578" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.52721" /MaxDrop="6.99686" /score="36.2618206" /energy="-12.6" /TU="U2372" /idTUdmin="U2373" /TUdmin=11 /isTUend="TRUE" /label="downshifts" misc_feature complement(2639570..2639589) /Source="Nicolas_upshift_promotors" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2639583) /Source="Nicolas_upshifts" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2639585..2639719) /Source="Nicolas_S_feature" /locus_tag="new_3135504_3135638_c" /HighExp="BT, B36, S8, S5, S7, Etha, S6, S4, B60, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK, SigB" /TUshortPSig="0.909, 1, 0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1170" upshifts complement(2639719) /Source="Nicolas_upshifts" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2639721..2639732) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2639747..2639753) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2639749..2640153) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative autolytic amidase" /protein_id="NP_390942.1" /db_xref="EnsemblGenomes-Gn:BSU30640" /db_xref="EnsemblGenomes-Tr:CAB15042" /db_xref="GOA:O34883" /db_xref="InterPro:IPR006480" /db_xref="SubtiList:BG13868" /db_xref="UniProtKB/Swiss-Prot:O34883" /translation="MDRDFGIFSFLAVSVSAAGFFFGGFQYSFLILLSLMAIEFISTT LKETIIHKLSFKKVFARLVKKLVTLALISVCHFFDQLLNTQGSIRDLAIMFYILYESV QIVVTASSLGIPVPQMLVDLLETLKNKFKRKP*" /label="ytkC CDS" gene complement(2639749..2640153) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /label="ytkC gene" promotor_-10 complement(2640181..2640200) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2640198) /Source="Nicolas_upshifts" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2640200..2640286) /Source="Nicolas_S_feature" /locus_tag="new_3136119_3136205_c" /HighExp="Etha, B36, S8, B60, S7, LoTm, Salt, Sw, Gly, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1171" promotor_-35 complement(2640213..2640222) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2640319..2640756) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12767829, 16091047, 16861227, 16935006; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-protecting protein, mini-ferritin" /protein_id="NP_390943.1" /db_xref="EnsemblGenomes-Gn:BSU30650" /db_xref="EnsemblGenomes-Tr:CAB15043" /db_xref="GOA:P80879" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="SubtiList:BG12584" /db_xref="UniProtKB/Swiss-Prot:P80879" /translation="MSEQLIQAVNKQVANWTVMYVKLHNYHWYVKGKDFFTLHEKFEE LYNETATYIDDLAERLLALNGKPIATMKESLETASVKEAAGNETAEQMVQSVYDDFTV IAEELKNGMDLADEVGDETTGDMLLAIHQNIEKHNWMLKAYLG*" /label="dps CDS" gene complement(2640319..2640756) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /label="dps gene" downshifts complement(2640331) /Source="Nicolas_upshifts" /id="D1579" /incds=0 /nref=188 /ntot=382 /MaxReadThrough="3.87056" /MaxDrop="7.83664" /score="36.0931083" /energy="-19.2" /TU="U2375" /idTUdmin="U2377" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2640773..2640791) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2640791) /Source="Nicolas_upshifts" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2640793..2641018) /Source="Nicolas_S_feature" /locus_tag="new_3136712_3136937_c" /HighExp="M0t90, Lbstat, M40t90, ferm, S2, nit, M40t45, S0, Lbtran, BT" /AntisenseName="ytzI" /AntisenseCor="-0.30531150128448598" /AntisenseRegPval="-6.5" /CDS_PredictionProba="0.38276900000000003" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1172" promotor_-35 complement(2640806..2640812) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2640848..2640867 /Source="Nicolas_upshift_promotors" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2640849..2641025 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097774.1" /db_xref="EnsemblGenomes-Gn:BSU30659" /db_xref="EnsemblGenomes-Tr:CAX52680" /db_xref="GOA:C0H3Q1" /db_xref="InterPro:IPR022248" /db_xref="UniProtKB/Swiss-Prot:C0H3Q1" /translation="MLQLLKNGRWNVMTLLITISILIVLAVLLVTIWTTVKAYNVKHT IDPPQENHSDSHNQ*" /label="ytzI CDS" gene 2640849..2641025 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /label="ytzI gene" upshifts 2640850 /Source="Nicolas_upshifts" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2641019..2641456) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390944.1" /db_xref="EnsemblGenomes-Gn:BSU30660" /db_xref="EnsemblGenomes-Tr:CAB15044" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR032693" /db_xref="SubtiList:BG11027" /db_xref="UniProtKB/Swiss-Prot:P40768" /translation="MKKMLVVLLFSALLLNGCGSGESKANTAETPEVLDVKLTGPEKV NPGESAAYEAAVSYGDEAVTDADEVEFEVWKEGEKDASQMFKVKQEKGVYRLETTFKE DGVYTVQSHVTAKKQHSMPTLKVQVGDADAASNQSEEEHSHHH*" /label="ytkA CDS" gene complement(2641019..2641456) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /label="ytkA gene" downshifts 2641045 /Source="Nicolas_upshifts" /id="D1580" /incds=0 /nref=37 /ntot=155 /MaxReadThrough="2.0116" /MaxDrop="3.95427" /score="13.1411485" /energy="-20.5" /TU="NA" /idTUdmin="U2376" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2641475..2641494) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-10" upshifts complement(2641496) /Source="Nicolas_upshifts" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="upshifts" promotor_-35 complement(2641505..2641513) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-35" CDS complement(2641576..2642049) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /EC_number="4.4.1.21" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-ribosylhomocysteine lyase" /protein_id="NP_390945.1" /db_xref="EnsemblGenomes-Gn:BSU30670" /db_xref="EnsemblGenomes-Tr:CAB15045" /db_xref="GOA:O34667" /db_xref="InterPro:IPR003815" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR037005" /db_xref="PDB:1IE0" /db_xref="PDB:1J98" /db_xref="PDB:1JQW" /db_xref="PDB:1JVI" /db_xref="PDB:1YCL" /db_xref="PDB:2FQO" /db_xref="PDB:2FQT" /db_xref="SubtiList:BG13866" /db_xref="UniProtKB/Swiss-Prot:O34667" /translation="MPSVESFELDHNAVVAPYVRHCGVHKVGTDGVVNKFDIRFCQPN KQAMKPDTIHTLEHLLAFTIRSHAEKYDHFDIIDISPMGCQTGYYLVVSGEPTSAEIV DLLEDTMKEAVEITEIPAANEKQCGQAKLHDLEGAKRLMRFWLSQDKEELLKVFG*" /label="luxS CDS" gene complement(2641576..2642049) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /label="luxS gene" downshifts complement(2641585) /Source="Nicolas_upshifts" /id="D1581" /incds=0 /nref=72 /ntot=201 /MaxReadThrough="4.53626" /MaxDrop="4.63695" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-793" /isTUend="FALSE" /label="downshifts" downshifts complement(2641672) /Source="Nicolas_upshifts" /id="D1582" /incds=1 /nref=1 /ntot=96 /MaxReadThrough="5.57623" /MaxDrop="2.4806" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" S_feature complement(2642050..2642401) /Source="Nicolas_S_feature" /locus_tag="new_3137969_3138320_c" /HighExp="Etha, B36, B60, BMM, S2, Heat, S1, LoTm, Lbtran, S5" /AntisenseName="ytjA" /AntisenseCor="-0.45038987072908898" /AntisenseRegPval="-14.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1173" promotor_-35 2642121..2642128 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2642141..2642160 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2642146 /Source="Nicolas_upshifts" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2642178..2642405 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19306042, 21803992; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein insertion efficiency factor" /protein_id="NP_390946.1" /db_xref="EnsemblGenomes-Gn:BSU30680" /db_xref="EnsemblGenomes-Tr:CAB15046" /db_xref="GOA:O34601" /db_xref="InterPro:IPR002696" /db_xref="SubtiList:BG13865" /db_xref="UniProtKB/Swiss-Prot:O34601" /translation="MKTLFIALIRGYQKFISPLTPPTCRFYPTCSQYGIEAIKTHGAL KGGWLTIKRILKCHPFHPGGVDPVPEKKQKH*" /label="ytjA CDS" gene 2642178..2642405 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /label="ytjA gene" CDS complement(2642402..2642965) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /EC_number="4.2.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12193617, 21266987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carbonic anhydrase" /protein_id="NP_390947.1" /db_xref="EnsemblGenomes-Gn:BSU30690" /db_xref="EnsemblGenomes-Tr:CAB15047" /db_xref="GOA:O34872" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG13863" /db_xref="UniProtKB/Swiss-Prot:O34872" /translation="MSLLNDILEFNKTFTEQREYEKYQTSKFPDKKMAILSCMDTRLV ELLPHAMNLRNGDVKIIKSAGALVTHPFGSIMRSILVAVYELNADEVCVIGHHDCGMS KISSKSMLEKIKARGIPEERIETIKYSGVDFDQWFKSFDSVEASVKDSVDVIKHHPLF PENVPVHGLVIDPKTGKLDLIVNGYNN*" /label="ytiB CDS" gene complement(2642402..2642965) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /label="ytiB gene" misc_feature complement(2642990..2643009) /Source="Nicolas_upshift_promotors" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2643005) /Source="Nicolas_upshifts" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2643059..2643307) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15049826, 16014871, 16547061, 19648245, 20208344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15049826, 16014871, 16547061, 19648245, 20208344; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_390948.1" /db_xref="EnsemblGenomes-Gn:BSU30700" /db_xref="EnsemblGenomes-Tr:CAB15048" /db_xref="GOA:O34967" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027493" /db_xref="InterPro:IPR034704" /db_xref="SubtiList:BG13862" /db_xref="UniProtKB/Swiss-Prot:O34967" /translation="MKEGIHPKNHKVIFQDVNSGYRFLSTSTKTSNETAEWEDGNTYP VIKVEVSSDTHPFYTGRQKFNEKGGRVEQFKKRYNMGK*" /label="rpmEB CDS" gene complement(2643059..2643307) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /label="rpmEB gene" downshifts complement(2643080) /Source="Nicolas_upshifts" /id="D1583" /incds=0 /nref=96 /ntot=217 /MaxReadThrough="7.96356" /MaxDrop="4.50701" /score="15.8096104" /energy="-7.5" /TU="U2380" /idTUdmin="U2380" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2643335..2643354) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-10" promotor_-35 complement(2643368..2643375) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-35" upshifts complement(2643372) /Source="Nicolas_upshifts" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="upshifts" promotor_-35 2643434..2643440 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-35" promotor_-10 2643454..2643465 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-10" upshifts 2643466 /Source="Nicolas_upshifts" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="upshifts" CDS 2643512..2644843 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9852001, 10551842, 15849754, 16850406, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit I" /protein_id="NP_390949.2" /db_xref="EnsemblGenomes-Gn:BSU30710" /db_xref="EnsemblGenomes-Tr:CAB15049" /db_xref="GOA:C0SP90" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG13857" /db_xref="UniProtKB/Swiss-Prot:C0SP90" /translation="MDDLVLARSLFGTTMGFHIIFATLGVGLPLMILVAELIYQKTKD DHYAIMAKRWTKAQAVLLGVAIPTGTIAGTQLALLWPGFMEVIGRVMSLPFQIEIYAF FVEALFMSIYVYAADRLSPAMRIVAVFFVLVGAAASAVLITNVHAFEGTPAGFKILNG KITDVDPWAAFFNPSFFITAGHVVLSAFMTGAFIVASVAAYKMIRTRKKERVYRFHRK ALLLALTIGGIFSLLTALNGHESAQMLYEYQPEKLAGAEGLFETRSHAPLAIGGFTDP NEEKVKWAIEIPWALSFLAANRFDTVVKGLNAFPRDEWPPLFIHTLFNAMVGVGMLLI LYSIIGVVWRKVLKKDRFPTWLLIIFMTAGPFSLIGIEFGWIFACTGRQPWVIYHLLK TSDVVTTTGSIGVLFLFFTFVYAVLGAAVVYVLLYYFRKHPVDEDLNTAES*" /label="ythA CDS" gene 2643512..2644843 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /label="ythA gene" CDS 2644887..2645927 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11073895, 15576792, 15849754, 16850406, 10551842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit II" /protein_id="NP_390950.1" /db_xref="EnsemblGenomes-Gn:BSU30720" /db_xref="EnsemblGenomes-Tr:CAB15050" /db_xref="GOA:O34505" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG13858" /db_xref="UniProtKB/Swiss-Prot:O34505" /translation="MEISTDALIAISIIWGFVFIYAVMATMDFGAGFWSMIYLNKEHM KATDIANRFLSPTWEVTNVFIVAIVVALFSFFPGATFVLGTVLLIPGSMILLLLAIRS GFLVFSNTAKERKTLRYISGISGFIIPAILILVLPVTHGGFIEKTDGIYNLNMSKIFS SPNAYSFIGFAILSTLFLSSLLLADFSNVAEEQDAYRAYRKSALITGPISLLFAVCIM VTMRNEANWLYSGMMNDFSWIIASFITFVIAGIALFLPNKSFGQNIGKPRLALVAIGI QYFLASYAYGRAHLPYMIYPDVTVMSGFTEPATFRALFATYIVAFIILFPGFFFFWKM FMRDKRYIRQEE*" /label="ythB CDS" gene 2644887..2645927 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /label="ythB gene" promotor_-35 2645921..2645927 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2645942..2645953 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2645952 /Source="Nicolas_upshifts" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="upshifts" CDS 2645981..2646139 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097775.1" /db_xref="EnsemblGenomes-Gn:BSU30739" /db_xref="EnsemblGenomes-Tr:CAX52681" /db_xref="InterPro:IPR011437" /db_xref="UniProtKB/Swiss-Prot:C0H3Q2" /translation="MEQKILCEVNNCSYWGKGNKCTADAIYVVSHTGETAENSRETDC KTFKPHDL*" /label="ytzL CDS" gene 2645981..2646139 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /label="ytzL gene" downshifts 2646128 /Source="Nicolas_upshifts" /id="D1584" /incds=0 /nref=55 /ntot=88 /MaxReadThrough="1.7679" /MaxDrop="7.01398" /score="-5.86934022" /energy="-7" /TU="NA" /idTUdmin="U2382" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2646158..2647045) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390952.1" /db_xref="EnsemblGenomes-Gn:BSU30740" /db_xref="EnsemblGenomes-Tr:CAB15052" /db_xref="GOA:O34500" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG13854" /db_xref="UniProtKB/Swiss-Prot:O34500" /translation="MSFEAWIIATGVLVGVSCGLIGTFLVLRSMAMLADAISHTVLLG IVGAFLVTGSLDGIYMFIGAAATGLLTAFLVQLLHSKGVQSDAAIGVVFTSLFAIGVI LLSVYGANVHLDIEHSLMGEIAFVPWNTVTVFGVDIGPKAFWMLASVLVLNVVLISVC YKEFKIASFDPQMALALGIPVLLIHYVQMGMLSLTTVASFDSVGAVLVVAMLIVPPAA AHLLTDRLLYMLILSALIGGLSAVMGYFFATWLNVSISGAMAAMTGVCYASAFLFSPA NGVITKKLRTLNMQKERAG*" /label="mntD CDS" gene complement(2646158..2647045) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /label="mntD gene" downshifts complement(2646181) /Source="Nicolas_upshifts" /id="D1585" /incds=0 /nref=121 /ntot=218 /MaxReadThrough="3.39755" /MaxDrop="6.80546" /score="-8.37820006" /energy="-7" /TU="U2385" /idTUdmin="U2385" /TUdmin="-637" /isTUend="FALSE" /label="downshifts" CDS complement(2647035..2648342) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390953.1" /db_xref="EnsemblGenomes-Gn:BSU30750" /db_xref="EnsemblGenomes-Tr:CAB15053" /db_xref="GOA:O35024" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13853" /db_xref="UniProtKB/Swiss-Prot:O35024" /translation="MFESLWLQLQHPNTQWVLAGTLLLGTASGVLGSFVLLRKQSLIG DAMAHSALPGVCLAFLFTGQKSLPFFLLGAALAGLLGTFCIQLIPRLSKTKEDSAIGI VLSVFFGVGIILLTYIQQQGAGSQSGLDSFLFGQAASLVRQDIILIAGISAVLLLLCI VFFKEFTLITFDLAFAKGLGIPVRFLNGLLACLIVCAVVIGLQTVGVILMAAMLITPA ITARYWTERLTGMIIIAGITGGVSGVAGTLLSTTMKGMATGPLMILSATLLFLFSMIC APKRGLAAKAIRLMRLRRRTSREQVLLAIYEQYEKNNLCVTVESVRKKRRLSPSLCLK ALNDLEQERCIERIENGIWQITSKGIEKGYHTALKQRMYEVYLMHEMELANIESDQDY FDPDRLPRETRERLYSLLKLYGRMPERRKASHDAEKGQIANEF*" /label="mntC CDS" gene complement(2647035..2648342) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /label="mntC gene" CDS complement(2648348..2649100) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type t: transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (ATP-binding protein)" /protein_id="NP_390954.1" /db_xref="EnsemblGenomes-Gn:BSU30760" /db_xref="EnsemblGenomes-Tr:CAB15054" /db_xref="GOA:O34338" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13852" /db_xref="UniProtKB/Swiss-Prot:O34338" /translation="MFPVELDNVTVAYHKKPVLQDISLQVPEGKLIGIIGPNGAGKST LIKTILGLVPRASGDISIYGKDYKDQRTRIGYVPQRGSVDWDFPTSPLDVVLMGRYGR IGLLKRPKKADVEMAKAALTKVGMHDYAKRQISQLSGGQQQRVFLARALCQNADIYFM DEPFAGVDAATERAIMTLLAELKEKGKTVLVVHHDLQTAEDYFDWILLLHLRKIAFGP TENVFTIENLQKTYGGRLTFLKDKVLAEGHKE*" /label="mntB CDS" gene complement(2648348..2649100) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /label="mntB gene" CDS complement(2649119..2650039) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (manganese binding lipoprotein)" /protein_id="NP_390955.1" /db_xref="EnsemblGenomes-Gn:BSU30770" /db_xref="EnsemblGenomes-Tr:CAB15055" /db_xref="GOA:O34385" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="SubtiList:BG13851" /db_xref="UniProtKB/Swiss-Prot:O34385" /translation="MRQGLMAAVLFATFALTGCGTDSAGKSADQQLQVTATTSQIADA AENIGGKHVKVTSLMGPGVDPHLYKASQGDTKKLMSADVVLYSGLHLEGKMEDVLQKI GEQKQSAAVAEAIPKNKLIPAGEGKTFDPHVWFSIPLWIYAVDEIEAQFSKAMPQHAD AFRKNAKEYKEDLQYLDKWSRKEIAHIPEKSRVLVTAHDAFAYFGNEYGFKVKGLQGL STDSDYGLRDVQELVDLLTEKQIKAVFVESSVSEKSINAVVEGAKEKGHTVTIGGQLY SDAMGEKGTKEGTYEGMFRHNINTITKALK*" /label="mntA CDS" gene complement(2649119..2650039) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /label="mntA gene" promotor_-10 complement(2650075..2650086) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2650076) /Source="Nicolas_upshifts" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2650078..2650169) /Source="Nicolas_S_feature" /locus_tag="new_3145997_3146088_c" /HighExp="T-0.40H, Sw, T-1.40H, BC, C90, C30, BI, T0.0H, T-3.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.985, 0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1174" promotor_-35 complement(2650100..2650106) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2650154 /Source="Nicolas_upshifts" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2650155..2650174) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2650157..2650169 /Source="Nicolas_upshift_promotors" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2650169) /Source="Nicolas_upshifts" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2650171..2650252) /Source="Nicolas_S_feature" /locus_tag="new_3146090_3146171_c" /HighExp="T1.30H, T1.0H, C30, T0.30H, T2.0H, T2.30H, T-0.40H, T-1.40H, T-2.40H, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1175" promotor_-35 complement(2650189..2650196) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2650252) /Source="Nicolas_upshifts" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="upshifts" promotor_-10 complement(2650261..2650280) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-10" promotor_-35 complement(2650294..2650301) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-35" CDS complement(2650319..2651434) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /EC_number="4.2.1.113" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoate-CoA synthase" /protein_id="NP_390956.1" /db_xref="EnsemblGenomes-Gn:BSU30780" /db_xref="EnsemblGenomes-Tr:CAB15056" /db_xref="GOA:O34514" /db_xref="InterPro:IPR010197" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG13847" /db_xref="UniProtKB/Swiss-Prot:O34514" /translation="MIEIEKITLYHLSMNLKKPFKNSIETLQERKFLIVEAIDTSGVT GWGEVSAFSSPWYTEETIGTCLHMLKDFFIPNVVGREFNHPSEVPDSLARYKGNRMAK AGLESAVWDIYAKKKGVSLAEALGGTRDKVPAGVVVGLAPLDDMLKEIESYQKEGYQR IKIKIQPGQDVELVKAIRSRFPTIPLMADANSSYELKDISRLKELDDYHLMMIEQPLQ ADDIVDHRHLQKHLKTAICLDESICSVDDARRAIELGSCKIINIKPSRVGGLTEALKI HDLCKEHHMQVWCGGMLETGISRAQNVALASLPQFTIPGDISSSSRYWDEDIVTPDIR IDNGFISVSKQPGLGVEVNQDIMRKYVTKMDVFTQHG*" /label="menC CDS" gene complement(2650319..2651434) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /label="menC gene" downshifts complement(2650362) /Source="Nicolas_upshifts" /id="D1586" /incds=0 /nref=12 /ntot=179 /MaxReadThrough="3.8638" /MaxDrop="2.96378" /score="29.7201414" /energy="-11.1" /TU="U2387,U2388" /idTUdmin="U2388" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2651431..2652891) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /EC_number="6.2.1.26" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299, 28559280" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299, 28559280; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoic acid-CoA ligase" /protein_id="NP_390957.1" /db_xref="EnsemblGenomes-Gn:BSU30790" /db_xref="EnsemblGenomes-Tr:CAB15057" /db_xref="GOA:P23971" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010192" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:5BUQ" /db_xref="PDB:5BUR" /db_xref="PDB:5BUS" /db_xref="PDB:5GTD" /db_xref="PDB:5X8F" /db_xref="PDB:5X8G" /db_xref="SubtiList:BG10687" /db_xref="UniProtKB/Swiss-Prot:P23971" /translation="MLTEQPNWLMQRAQLTPERIALIYEDQTVTFAELFAASKRMAEQ LAAHSVRKGDTAAILLQNRAEMVYAVHACFLLGVKAVLLNTKLSTHERLFQLEDSGSG FLLTDSSFEKKEYEHIVQTIDVDELMKEAAEEIEIEAYMQMDATATLMYTSGTTGKPK GVQQTFGNHYFSAVSSALNLGITEQDRWLIALPLFHISGLSALFKSVIYGMTVVLHQR FSVSDVLHSINRHEVTMISAVQTMLASLLEETNRCPESIRCILLGGGPAPLPLLEECR EKGFPVFQSYGMTETCSQIVTLSPEFSMEKLGSAGKPLFSCEIKIERDGQVCEPYEHG EIMVKGPNVMKSYFNRESANEASFQNGWLKTGDLGYLDNEGFLYVLDRRSDLIISGGE NIYPAEVESVLLSHPAVAEAGVSGAEDKKWGKVPHAYLVLHKPVSAGELTDYCKERLA KYKIPAKFFVLDRLPRNASNKLLRNQLKDARKGELL*" /label="menE CDS" gene complement(2651431..2652891) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /label="menE gene" promotor_-10 complement(2652334..2652352) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2652338) /Source="Nicolas_upshifts" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2652367..2652373) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2652980) /Source="Nicolas_upshifts" /id="D1587" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="4.92536" /MaxDrop="2.4145" /score="1.01127104" /energy="-10.8" /TU="U2388" /idTUdmin="U2389" /TUdmin=682 /isTUend="FALSE" /label="downshifts" CDS complement(2652982..2653797) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /EC_number="4.1.3.36" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxynapthoic acid synthetase" /protein_id="NP_390958.1" /db_xref="EnsemblGenomes-Gn:BSU30800" /db_xref="EnsemblGenomes-Tr:CAB15058" /db_xref="GOA:P23966" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR010198" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG10686" /db_xref="UniProtKB/Swiss-Prot:P23966" /translation="MAEWKTKRTYDEILYETYNGIAKITINRPEVHNAFTPKTVAEMI DAFADARDDQNVGVIVLAGAGDKAFCSGGDQKVRGHGGYVGDDQIPRLNVLDLQRLIR VIPKPVVAMVSGYAIGGGHVLHIVCDLTIAADNAIFGQTGPKVGSFDAGYGSGYLARI VGHKKAREIWYLCRQYNAQEALDMGLVNTVVPLEQLEEETIKWCEEMLEKSPTALRFL KAAFNADTDGLAGIQQFAGDATLLYYTTDEAKEGRDSFKEKRKPDFGQFPRFP*" /label="menB CDS" gene complement(2652982..2653797) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /label="menB gene" CDS complement(2653832..2654656) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /EC_number="4.2.99.20" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12454479, 23637813; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase" /protein_id="NP_390959.1" /db_xref="EnsemblGenomes-Gn:BSU30810" /db_xref="EnsemblGenomes-Tr:CAB15059" /db_xref="GOA:P23974" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR022485" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10685" /db_xref="UniProtKB/Swiss-Prot:P23974" /translation="MGTVNITVSDGVRYAVADEGPNASEAVVCLHGFTGSKQSWTFLD EMLPDSRLIKIDCLGHGETDAPLNGKRYSTTRQVSDLAEIFDQLKLHKVKLIGYSMGG RLAYSFAMTYPERVSALVLESTTPGLKTLGERRERIMRDRKLADFILRDGLEAFVAYW ENIPLFSSQQRLAEDIRYRIRSGRLRNNKIGLANSLTGMGTGSQPSLWSRVEEIDVPV LLICGEWDEKFCAINQEVHKMLPSSRIEIVPKAGHTVHVEQPRLFGKIVSEFLTSI*" /label="menH CDS" gene complement(2653832..2654656) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /label="menH gene" promotor_-10 complement(2653914..2653933) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2653914) /Source="Nicolas_upshifts" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2653949..2653952) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2654080) /Source="Nicolas_upshifts" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2654090..2654101) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2654116..2654122) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2654644..2656386) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /EC_number="2.2.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate decarboxylase and 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase" /protein_id="NP_390960.1" /db_xref="EnsemblGenomes-Gn:BSU30820" /db_xref="EnsemblGenomes-Tr:CAB15060" /db_xref="GOA:P23970" /db_xref="InterPro:IPR004433" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR032264" /db_xref="PDB:2X7J" /db_xref="SubtiList:BG10683" /db_xref="UniProtKB/Swiss-Prot:P23970" /translation="MTVNPITHYIGSFIDEFALSGITDAVVCPGSRSTPLAVLCAAHP DISVHVQIDERSAGFFALGLAKAKQRPVLLICTSGTAAANFYPAVVEAHYSRVPIIVL TADRPHELREVGAPQAINQHFLFGNFVKFFTDSALPEESPQMLRYIRTLASRAAGEAQ KRPMGPVHVNVPLREPLMPDLSDEPFGRMRTGRHVSVKTGTQSVDRESLSDVAEMLAE AEKGMIVCGELHSDADKENIIALSKALQYPILADPLSNLRNGVHDKSTVIDAYDSFLK DDELKRKLRPDVVIRFGPMPVSKPVFLWLKDDPTIQQIVIDEDGGWRDPTQASAHMIH CNASVFAEEIMAGLTAATRSSEWLEKWQFVNGRFREHLQTISSEDVSFEGNLYRILQH LVPENSSLFVGNSMPIRDVDTFFEKQDRPFRIYSNRGANGIDGVVSSAMGVCEGTKAP VTLVIGDLSFYHDLNGLLAAKKLGIPLTVILVNNDGGGIFSFLPQASEKTHFEDLFGT PTGLDFKHAAALYGGTYSCPASWDEFKTAYAPQADKPGLHLIEIKTDRQSRVQLHRDM LNEAVREVKKQWEL*" /label="menD CDS" gene complement(2654644..2656386) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /label="menD gene" CDS complement(2656383..2657798) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /EC_number="5.4.4.2" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinone-specific isochorismate synthase" /protein_id="NP_390961.1" /db_xref="EnsemblGenomes-Gn:BSU30830" /db_xref="EnsemblGenomes-Tr:CAB15061" /db_xref="GOA:P23973" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR034681" /db_xref="SubtiList:BG10682" /db_xref="UniProtKB/Swiss-Prot:P23973" /translation="MVTTVQRTFRKEVLHALHKAKEVNHAVLISYSRQIESLDPLSFF NYGAKKYTGNRFFWSDPESELTIVGLGKEAVFQTNQKNSERYREVFEQWERFKKTAFH IYEEEKLQHSAVGPVLFGGFSFDPCEERGSQWDHFSEGDFFVPALMLTMTAEGPFLTV NRWVSGGEDAEAVLEGLKAFAAEFMVPDFKQEDQAVIAAAEELDKDDWLKAIETATSQ IKEKQYDKVVLARELLLTFDGPIQIEPVLKTLLDDQQTSYVFAIEQEGKTFVGASPER LIKRDGGTVMSSCLAGSIKRGVNEEDDRRIGLELLNDEKNLLEHDIVVGMIHNAFVSS CSEVEKPDGPVLYKTKSVQHLFTPIVGQLRESASIFDLIEKLHPTPALGGSPQEKAVD VIREIEPMSRGWYAAPIGWIDSQDNGEFAVAIRSGLIEGSTARLFAGCGIVEDSEPIS EYEETQIKLKPMISALGGERR*" /label="menF CDS" gene complement(2656383..2657798) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /label="menF gene" S_feature complement(2657799..2657911) /Source="Nicolas_S_feature" /locus_tag="new_3153718_3153830_c" /HighExp="dia5, LBGstat, Diami, LBGtran, dia15, H2O2, G180, G150, LPhT, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1176" promotor_-10 complement(2657891..2657910) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-10" upshifts complement(2657911) /Source="Nicolas_upshifts" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="upshifts" S_feature complement(2657913..2658063) /Source="Nicolas_S_feature" /locus_tag="new_3153832_3153982_c" /HighExp="S8, S7, S6, S5, BT, S4, Pyr, B36, G/S, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1177" promotor_-35 complement(2657926..2657929) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-35" promotor_-35 2658024..2658030 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2658044..2658063) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2658044..2658055 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2658052 /Source="Nicolas_upshifts" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2658063) /Source="Nicolas_upshifts" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2658077..2658086) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2658088..2658807 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative regulatory protein" /protein_id="NP_390962.2" /db_xref="EnsemblGenomes-Gn:BSU30840" /db_xref="EnsemblGenomes-Tr:CAB15062" /db_xref="GOA:P42408" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR014240" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG11200" /db_xref="UniProtKB/Swiss-Prot:P42408" /translation="MLTKEQLQHLKNELEQTKKDILNRFKDNDHFQLNSAFPYDSWGE LSAYDNHPGDQATELYEREKDIALDLHEREHLRDIEHSLKAIENGTYGICEVSGKEIP FERLEALPTATTLAEYSSQDVVSKDRPIEEETPFGQFEFDDDEEIRAPYDSEDSYQDV EKYGNSQTPQDMENPPLSYDDMTMNAEENIGNTESYENFIATDITGKEITVYQSRAHE RYEEELDEEGIMTTFGDLHAD*" /label="yteA CDS" gene 2658088..2658807 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /label="yteA gene" S_feature complement(2658158..2658815) /Source="Nicolas_S_feature" /locus_tag="new_3154077_3154734_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, S3" /AntisenseName="yteA" /AntisenseCor="0.85796245341056299" /AntisenseRegPval="-78.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1178" downshifts 2658796 /Source="Nicolas_upshifts" /id="D1588" /incds=0 /nref=23 /ntot=40 /MaxReadThrough="0.72949" /MaxDrop="5.85132" /score="2.75726503" /energy="-10.1" /TU="NA" /idTUdmin="U2391" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2658816..2659634) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_390963.1" /db_xref="EnsemblGenomes-Gn:BSU30850" /db_xref="EnsemblGenomes-Tr:CAB15063" /db_xref="GOA:P42407" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11199" /db_xref="UniProtKB/Swiss-Prot:P42407" /translation="MIKKAIIPAGGFGTRNLPVTKVIPKEMFPVGSKPVIHYLVEELK ESGIEDILMVVSSHKNLIVDYFDSSLALEAFLASKNKLHLLREHPIPDIRIHYVRQPY AKGLGDAISFGKQFAGGEPFAVVLPDDLIFSANQPALGQLIEAYTKYQSSVIGLKETK TEDLHHYGVIKGEPVEKGLYRIQDIVEKPKQNPPSHFAAAGRYIFTPDIFNELEALEA DSGGEVQVTDAIKASLGACTVYGKLLEGERYDIGLQKDYLKLIYDMLKTEKNPQ*" /label="ytdA CDS" gene complement(2658816..2659634) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /label="ytdA gene" promotor_-10 complement(2659655..2659674) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2659669) /Source="Nicolas_upshifts" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2659689..2659697) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2659735..2659743 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2659756..2659775 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2659757 /Source="Nicolas_upshifts" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="upshifts" CDS 2659806..2661092 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /EC_number="1.1.1.22" /function="16.14: Store" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose dehydrogenase" /protein_id="NP_390964.1" /db_xref="EnsemblGenomes-Gn:BSU30860" /db_xref="EnsemblGenomes-Tr:CAB15064" /db_xref="GOA:O34862" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13828" /db_xref="UniProtKB/Swiss-Prot:O34862" /translation="MKICVVGAGYVGLTLSAALASIGHDMICTDKDVKKIGQLKKGVI PFYEPGLSDAILRCGNLSFSSEVKSSMEECPVIFIAVGTPPRSDGSADTKALQSVIGD LSEAIRSYKTIITKSTVPPGTNENIAKQLIASGVSKNLFNIVSNPEFLREGNALYDML HPDKTVIGVQEEDHVSAAIVKSIYKHIDTPFIVTSLAGAELIKYANNFFLAAKISFIN EMARICEAYQSDISDISRAIGLDPRIGKHFLQAGIGYGGSCFPKDLQALQFAAQEKNT ETFLLRAVQHINDTQLGLYIKKIQSFFETLQGKKAAVLGISFKPNTDDIRNSQAVRLM ERLAELGCDVHAYDPEAVLPEHLRQHVTQHSQAFDAIEESDFLFLATEWSEFLAFDWK KAADIMKGRLVIDGRNVLKKELIEACGLICTGVGRP*" /label="ytcA CDS" gene 2659806..2661092 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /label="ytcA gene" CDS 2661089..2662039 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose epimerase" /protein_id="NP_390965.1" /db_xref="EnsemblGenomes-Gn:BSU30870" /db_xref="EnsemblGenomes-Tr:CAB15065" /db_xref="GOA:O34886" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13829" /db_xref="UniProtKB/Swiss-Prot:O34886" /translation="MKILVTGAAGFIGSHLCEELLKDKKHNVIGIDDFIGPTPFSLKL KNLKNLLPEKRFTFIKENLLTADLASLLEGVDVIFHLAAIPGVRSSWGNHFHPYAAHN IQALQRLLEACREHSIQTFVFASTSSVYGEKQGKVSENTSLSPLSPYGVTKLTGEKLC HVYKQSFGIPIVILRFFTVYGPRQRPDMAFHRLIKQHLQQKPLTIFGDGQQSRDFTYI SDCVKGITAVLGKPHLIGETVNIGGAERASVLKVVSLIEDISGRKATLHFSDKIAGEP SNTWADISKAKQLLHYDPATSLKDGLTNEIAYLSSLYQGE*" /label="ytcB CDS" gene 2661089..2662039 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /label="ytcB gene" CDS 2662042..2663265 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /EC_number="2.4.1.-" /function="16.14: Store" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glucosyltransferase" /protein_id="NP_390966.1" /db_xref="EnsemblGenomes-Gn:BSU30880" /db_xref="EnsemblGenomes-Tr:CAB15066" /db_xref="GOA:O34413" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG13830" /db_xref="UniProtKB/Swiss-Prot:O34413" /translation="MKLAFICTEKLPAPAVRGGAIQMMIDGVTPYFSSRYDLTIFSIE DPSLPKRETKDGVHYIHLPKEHYREAVAEELRASSFDLIHVFNRPLNVSLYKKASPNS KIVLSLHNEMFSEKKMTFAQGKEVLDNVSMITTVSEFIKQTVIERFPEAEDITKVVYS GVDLNSYPPVWTMKGSAVRKTYRKKYGIEDKKVILFAGRLSPTKGPHLLIHSMRRILQ QHPDAVLVIAGGKWFSDDSENQYVTYLRTLALPYRDHIIFTKFIPADDIPNLFLMADV FVCSSQWNEPLARVNYEAMAAGTPLITTNRGGNGEVVKHEVTGLVIDSYNKPSSFAKA IDRAFTDQELMNKMTKNARKHVEALFTFTHAAKRLNTVYQSVLTPKNKQFPPPFLTQN FDLSSINQLFVKAKT*" /label="ytcC CDS" gene 2662042..2663265 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /label="ytcC gene" downshifts complement(2663189) /Source="Nicolas_upshifts" /id="D1589" /incds=1 /nref=1 /ntot=10 /MaxReadThrough="1.32025" /MaxDrop="3.47267" /score="-3.65321449" /energy="-3.1" /TU="NA" /idTUdmin="U2395" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature 2663266..2663833 /Source="Nicolas_S_feature" /locus_tag="new_3159185_3159752" /HighExp="S8, S7, BT, S6, C30, Pyr, S5, G/S, C90, Glucon" /AntisenseName="ytxO" /AntisenseCor="0.86121563743373297" /AntisenseRegPval="-79.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1179" CDS complement(2663339..2663770) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="outer spore coat protein" /protein_id="NP_390967.1" /db_xref="EnsemblGenomes-Gn:BSU30890" /db_xref="EnsemblGenomes-Tr:CAB15067" /db_xref="SubtiList:BG11382" /db_xref="UniProtKB/Swiss-Prot:P46916" /translation="MRSSRQKASISKLDLDQFVFTPPGPMGWQAHDSISAEKEEEEKH LDVGSIRELPHINAPKEYQKETKEKETDRKIVDDEEETKFETTLEPEEERDSKRSAPP YEEEDEDEEPDLAEEAKVEIIILPSESKPAPWFSQTVKRKA*" /label="cotOO CDS" gene complement(2663339..2663770) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /label="cotOO gene" downshifts complement(2663365) /Source="Nicolas_upshifts" /id="D1590" /incds=0 /nref=11 /ntot=36 /MaxReadThrough="3.07378" /MaxDrop="4.8822" /score="9.30990044" /energy="-8.3" /TU="U2395" /idTUdmin="U2395" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(2663772..2664827) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7545510, 9603889, 10234840, 11737650, 14702409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7545510, 9603889, 10234840, 11737650, 14702409; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390968.1" /db_xref="EnsemblGenomes-Gn:BSU30900" /db_xref="EnsemblGenomes-Tr:CAB15068" /db_xref="GOA:P46914" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="SubtiList:BG11380" /db_xref="UniProtKB/Swiss-Prot:P46914" /translation="MYQKEHEEQIVSEILSYYPFHIDHVALKSNKSGRKIWEVETDHG PKLLKEAQMKPERMLFITQAHAHLQEKGLPIAPIHQTKNGGSCLGTDQVSYSLYDKVT GKEMIYYDAEQMKKVMSFAGHFHHASKGYVCTDESKKRSRLGKWHKLYRWKLQELEGN MQIAASYPDDVFSQTFLKHADKMLARGKEALRALDDSEYETWTKETLEHGGFCFQDFT LARLTEIEGEPFLKELHSITYDLPSRDLRILLNKVMVKLSVWDTDFMVALLAAYDAVY PLTEKQYEVLWIDLAFPHLFCAIGHKYYLKQKKTWSDEKYNWALQNMISVEESKDSFL DKLPELYKKIKAYREAN*" /label="cotS CDS" gene complement(2663772..2664827) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /label="cotS gene" CDS complement(2664842..2665975) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9603889, 10234840, 11737650" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9603889, 10234840, 11737650; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390969.1" /db_xref="EnsemblGenomes-Gn:BSU30910" /db_xref="EnsemblGenomes-Tr:CAB15069" /db_xref="GOA:P46915" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11381" /db_xref="UniProtKB/Swiss-Prot:P46915" /translation="MKIALIATEKLPVPSVRGGAIQIYLEAVAPLIAKKHEVTVFSIK DPNLADREKVDGVHYVHLDEDRYEEAVGAELKKSRFDLVHVCNRPSWVPKLKKQAPDA VFILSVHNEMFAYDKISQAEGEICIDSVAQIVTVSDYIGQTITSRFPSARSKTKTVYS GVDLKTYHPRWTNEGQRAREEMRSELGLHGKKIVLFVGRLSKVKGPHILLQALPDIIE EHPDVMMVFIGSKWFGDNELNNYVKHLHTLGAMQKDHVTFIQFVKPKDIPRLYTMSDV FVCSSQWQEPLARVHYEAMAAGLPIITSNRGGNPEVIEEGKNGYIIHDFENPKQYAER INDLLSSSEKRERLGKYSRREAESNFGWQRVAENLLSVYEKNR*" /label="cotSA CDS" gene complement(2664842..2665975) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /label="cotSA gene" promotor_-10 complement(2666008..2666027) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2666027) /Source="Nicolas_upshifts" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2666040..2666049) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2666113..2666122 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2666136..2666155 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2666138 /Source="Nicolas_upshifts" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="upshifts" CDS 2666165..2667238 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816, 20077512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 20077512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat kinase" /protein_id="NP_390970.1" /db_xref="EnsemblGenomes-Gn:BSU30920" /db_xref="EnsemblGenomes-Tr:CAB15070" /db_xref="GOA:O34656" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="PDB:2Q83" /db_xref="SubtiList:BG13821" /db_xref="UniProtKB/Swiss-Prot:O34656" /translation="MCPLMAENHEVIEEGNSSELPLSAEDAKKLTELAENVLQGWDVQ AEKIDVIQGNQMALVWKVHTDSGAVCLKRIHRPEKKALFSIFAQDYLAKKGMNVPGIL PNKKGSLYSKHGSFLFVVYDWIEGRPFELTVKQDLEFIMKGLADFHTASVGYQPPNGV PIFTKLGRWPNHYTKRCKQMETWKLMAEAEKEDPFSQLYLQEIDGFIEDGLRIKDRLL QSTYVPWTEQLKKSPNLCHQDYGTGNTLLGENEQIWVIDLDTVSFDLPIRDLRKMIIP LLDTTGVWDDETFNVMLNAYESRAPLTEEQKQVMFIDMLFPYELYDVIREKYVRKSAL PKEELESAFEYERIKANALRQLI*" /label="cotI CDS" gene 2666165..2667238 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /label="cotI gene" promotor_-35 2666462..2666468 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2666479 /Source="Nicolas_upshifts" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2666482..2666493 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2667227 /Source="Nicolas_upshifts" /id="D1591" /incds=0 /nref=16 /ntot=35 /MaxReadThrough="3.14769" /MaxDrop="5.1897" /score="-2.47616606" /energy="-10.3" /TU="U2396,U2397" /idTUdmin="U2396" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 2667265..2667271 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2667286 /Source="Nicolas_upshifts" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2667287..2667305 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2667318..2667785 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717291, 15849754, 16850406; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative receptor" /protein_id="NP_390971.1" /db_xref="EnsemblGenomes-Gn:BSU30930" /db_xref="EnsemblGenomes-Tr:CAB15071" /db_xref="GOA:O34694" /db_xref="InterPro:IPR004307" /db_xref="SubtiList:BG13822" /db_xref="UniProtKB/Swiss-Prot:O34694" /translation="MKKIVGALAVFVITYALFSAAGYLFPVDQEWYNSLKKPDWTPSG TAIGIIWAILFALISLSAAIVYAAFSFKGAKSFWFTLLINYVLNQAFSYFQFTQKNLL AASLDCLLVAITAIVLLIIAKKYSRAASYLLLPYFLWSAFATFLSFTINSMNL*" /label="ytaB CDS" gene 2667318..2667785 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /label="ytaB gene" downshifts 2667757 /Source="Nicolas_upshifts" /id="D1592" /incds=0 /nref=43 /ntot=123 /MaxReadThrough="2.47485" /MaxDrop="5.7907" /score="9.10214462" /energy="-10.1" /TU="NA" /idTUdmin="U2396" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2667816..2670212) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /EC_number="2.4.1.1" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8145641, 9244254, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen phosphorylase" /protein_id="NP_390972.1" /db_xref="EnsemblGenomes-Gn:BSU30940" /db_xref="EnsemblGenomes-Tr:CAB15072" /db_xref="GOA:P39123" /db_xref="InterPro:IPR000811" /db_xref="InterPro:IPR011833" /db_xref="InterPro:IPR035090" /db_xref="SubtiList:BG10911" /db_xref="UniProtKB/Swiss-Prot:P39123" /translation="MFSSKERFADLFLKRLEMTCGKSFKDSAKLDQYKTLGNMVREYI SADWIETNEKSRSNSGKQTYYLSIEFLLGQLLEQNLMNLGVRDVVEAGLKEIGINLEE ILQIENDAGLGNGGLGRLAACFLDSLASLNLPGHGMGIRYKHGLFEQKIVDGHQVELP EQWLKNGNVWEVRNADQAVDVPFWGEVHMTEKSGRLHFRHEQATIVTAVPYDIPIIGY ETGTVNTLRLWNAEPYAHYHGGNILSYKRETEAVSEFLYPDDTHDEGKILRLKQQYFL VCASLKSIVNNYRKTHKSLSGLHKKVSIHINDTHPALAVPELMRILLDEENMSWEEAW HITVHTISYTNHTTLSEALEKWPIHLFKPLLPRMYMIIEEINERFCRAVWEKYPGDWK RIENMAITAHGVVKMAHLAIVGSYSVNGVAKIHSDILKEREMRDFHLLFPNRFNNKTN GIAHRRWLLKANPGLSAIITEAIGDEWVKQPESLIRLEPYATDPAFIEQFQNNKSKKK QELADLIFCTAGVVVNPESIFDVQVKRLHAYKRQLLNVLHIMYLYNRLKEDSGFSIYP QTFIFGAKASPSYYYAKKIIKLIHSVAEKVNYDPAVKQLIKVVFLENYRVSMAERIFP ASDVSEQISTASKEASGTGNMKFMMNGALTIGTHDGANIEILERVGPDCIYTFGLKAD EVLSYQENGGYRSREYYQHDRRIRQVADQLINGFFEGEADEFESIFDSLLPHNDEYFV LKDFSSYADAQERIQADYRERRKWSEHSIVNIAHSGYFSSDRTIREYAKDIWGIKPMM *" /label="glgP CDS" gene complement(2667816..2670212) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /label="glgP gene" downshifts complement(2667831) /Source="Nicolas_upshifts" /id="D1593" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="2.31076" /MaxDrop="4.39135" /score="34.694666" /energy="-10.1" /TU="NA" /idTUdmin="U2399" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2670199..2671653) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /EC_number="2.4.1.21" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:8145641, 15272305" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8145641, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen (starch) synthase" /protein_id="NP_390973.1" /db_xref="EnsemblGenomes-Gn:BSU30950" /db_xref="EnsemblGenomes-Tr:CAB15073" /db_xref="GOA:P39125" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR011835" /db_xref="InterPro:IPR013534" /db_xref="SubtiList:BG10910" /db_xref="UniProtKB/Swiss-Prot:P39125" /translation="MKILFAVSECTPFVKSGGLADVAGALPKALARLGNEVAVMLPKY SQIPEPWKKRMKKQAECTVAVGWRQQYCGIEHMAENDVNYYFIDNEYYFNRDSLYGHY DDGERFAFFSRAVLEAAKVVNVQADIVHTHDWHTAMVNYLLKEEYRKHPFYERMKSVL TIHNLQFQGIFPPDVTHDLLGLEMDHFHYERLECNGFVNFMKAGIIAADHVTTVSPTY RNEIMTPYYGEQLEQVLQYREDDVTGILNGIDDTFYQPKSDPYIEAQYDSGDLACKLE NKTKLQQRMGLPEKNDIPLISMVTRLTKQKGLDLVRRIMHELLEEQDIQLVVLGTGER EFEDYFRYAEFAFHEKCRAYIGFDEPLAHQIYAGSDMFLMPSKFEPCGLGQLIALQYG AIPIVRETGGLYDTVRAYQEEEGTGNGFTFSAFNAHDLKFTIERALSFYCQQDVWKSI VKTAMNADYSWGKSAKEYQRIFEQVTRSGRDVLE*" /label="glgA CDS" gene complement(2670199..2671653) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /label="glgA gene" CDS complement(2671650..2672681) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) beta subunit" /protein_id="NP_390974.1" /db_xref="EnsemblGenomes-Gn:BSU30960" /db_xref="EnsemblGenomes-Tr:CAB15074" /db_xref="GOA:P39124" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011832" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10909" /db_xref="UniProtKB/Swiss-Prot:P39124" /translation="MFNNQMLGVIDETTYKHSLQDLTAQRSLGAIPFAGRYRLIDFML SNMVNADIRSVAIFPKYRYRSLMDHLGAGKEWDLHRKKDGLFFFPSPHLHHEYDEFGS FRQFSDHLDYFHRSTQQYAVISNSHTVCNIQFQYVLKRHQEVGCDVTEVFQDGQSLQI YIMSTTLLKDLIYGHSEKGYKTIQEAVEKESSALTICPYEYSGYAAVIDSVEKYYTHS MELIQPRFWQQVFLPQQPIYTKVKDEPPTKYGKHSTVKNSLVANGCVLEGEVENCILF RAVHVGKGTKLKNCIIMQKTQIGEDCLLEQVISDKDVKIGKATEAAGTAEQPLVLRKG LVQGELMNS*" /label="glgD CDS" gene complement(2671650..2672681) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /label="glgD gene" CDS complement(2672705..2673847) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) subunit alpha" /protein_id="NP_390975.1" /db_xref="EnsemblGenomes-Gn:BSU30970" /db_xref="EnsemblGenomes-Tr:CAB15075" /db_xref="GOA:P39122" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005836" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011831" /db_xref="InterPro:IPR023049" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10908" /db_xref="UniProtKB/Swiss-Prot:P39122" /translation="MKKQCVAMLLAGGKGSRLSGLTKNMAKPAVSFGGKYRIIDFTLS NCSNSGIDTVGILTQYQPLELNSYIGIGSAWDLDRYNGGVTVLPPYAESSEVKWYKGT ASSIYENLNYLNQYDPEYVLILSGDHIYKMDYGKMLDYHIEKKADVTISVIEVGWEEA SRFGIMKANPDGTITHFDEKPKFPKSNLASMGIYIFNWPLLKQYLEMDDQNPYSSHDF GKDIIPLLLEEKKKLSAYPFKGYWKDVGTVQSLWEANMDLLKEDSELKLFERKWKIYS VNPNQPPQFISSDAQVQDSLVNEGCVVYGNVSHSVLFQGVTVGKHTTVTSSVIMPDVT IGEHVVIENAIVPNGMVLPDGAVIRSEKDIEEVLLVSEEFVEKELI*" /label="glgC CDS" gene complement(2672705..2673847) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /label="glgC gene" CDS complement(2673844..2675727) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /EC_number="2.4.1.18" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1296817, 15272305, 8145641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-alpha-glucan branching enzyme" /protein_id="NP_390976.1" /db_xref="EnsemblGenomes-Gn:BSU30980" /db_xref="EnsemblGenomes-Tr:CAB15076" /db_xref="GOA:P39118" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR006048" /db_xref="InterPro:IPR006407" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG10907" /db_xref="UniProtKB/Swiss-Prot:P39118" /translation="MAAASPTAHDVYLFHEGSLFKSYQLFGSHYRELNGKSGYEFCVW APHASEVRVAGDFNSWSGEEHVMHRVNDNGIWTLFIPGIGEKERYKYEIVTNNGEIRL KADPYAIYSEVRPNTASLTYDLEGYSWQDQKWQKKQKAKTLYEKPVFIYELHLGSWKK HSDGRHYSYKELSQTLIPYIKKHGFTHIELLPVYEHPYDRSWGYQGTGYYSPTSRFGP PHDLMKFVDECHQQNIGVILDWVPGHFCKDAHGLYMFDGEPLYEYKEERDRENWLWGT ANFDLGKPEVHSFLISNALYWAEFYHIDGFRVDAVANILYWPNQDERHTNPYAVDFLK KLNQTMREAYPHVMMIAEDSTEWPQVTGAVEEGGLGFHYKWNMGWMNDVLKYMETPPE ERRHCHQLISFSLLYAFSEHFVLPFSHDEVVYGKKSLLNKMPGDYWQKFAQYRLLLGY MTVHPGKKLIFMGSEFAQFDEWKDTEQLDWFLDSFPMHQKASVFTQDLLRFYQKSKIL YEHDHRAQSFEWIDVHNDEQSIFSFIRYGQKHGEALVIICNFTPVVYHQYDVGVPFFT QYIEVLNSDSETYGGSGQINKKPLSAKKGALHHKPCYITMTIPPYGISILRAVKKRGE IKR*" /label="glgB CDS" gene complement(2673844..2675727) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /label="glgB gene" S_feature 2674553..2675972 /Source="Nicolas_S_feature" /locus_tag="new_3170472_3171891" /HighExp="S8, S7, S6, C30, BT, Pyr, G/S, S2, C90, BC" /AntisenseName="glgB" /AntisenseCor="0.59299722159013002" /AntisenseRegPval="-26.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1180" promotor_-10 complement(2675759..2675774) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2675772) /Source="Nicolas_upshifts" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2675789..2675794) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2675839) /Source="Nicolas_upshifts" /id="D1594" /incds=0 /nref=2 /ntot=46 /MaxReadThrough="1.66182" /MaxDrop="3.12741" /score="36.0363304" /energy="-9.2" /TU="NA" /idTUdmin="U2401" /TUdmin=198 /isTUend="FALSE" /label="downshifts" tRNA complement(2675960..2676031) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Glu tRNA" gene complement(2675960..2676031) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /label="trnB-Glu gene" tRNA complement(2676057..2676147) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ser2 tRNA" gene complement(2676057..2676147) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /label="trnB-Ser2 gene" tRNA complement(2676151..2676225) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Asn tRNA" gene complement(2676151..2676225) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /label="trnB-Asn gene" tRNA complement(2676236..2676312) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ile2 tRNA" gene complement(2676236..2676312) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /label="trnB-Ile2 gene" tRNA complement(2676328..2676401) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Gly2 tRNA" gene complement(2676328..2676401) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /label="trnB-Gly2 gene" tRNA complement(2676412..2676487) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-His tRNA" gene complement(2676412..2676487) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /label="trnB-His gene" tRNA complement(2676505..2676580) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Phe tRNA" gene complement(2676505..2676580) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /label="trnB-Phe gene" tRNA complement(2676593..2676669) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Asp tRNA" gene complement(2676593..2676669) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /label="trnB-Asp gene" tRNA complement(2676681..2676757) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met2 tRNA" gene complement(2676681..2676757) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /label="trnB-Met2 gene" tRNA complement(2676775..2676867) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ser1 tRNA" gene complement(2676775..2676867) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /label="trnB-Ser1 gene" tRNA complement(2676874..2676950) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met3 tRNA" gene complement(2676874..2676950) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /label="trnB-Met3 gene" tRNA complement(2676953..2677029) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met1 tRNA" gene complement(2676953..2677029) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /label="trnB-Met1 gene" tRNA complement(2677049..2677121) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ala tRNA" gene complement(2677049..2677121) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /label="trnB-Ala gene" tRNA complement(2677127..2677203) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Pro tRNA" gene complement(2677127..2677203) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /label="trnB-Pro gene" tRNA complement(2677219..2677295) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Arg tRNA" gene complement(2677219..2677295) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /label="trnB-Arg gene" tRNA complement(2677305..2677390) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Leu2 tRNA" gene complement(2677305..2677390) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /label="trnB-Leu2 gene" tRNA complement(2677405..2677479) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Gly1 tRNA" gene complement(2677405..2677479) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /label="trnB-Gly1 gene" tRNA complement(2677485..2677571) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Leu1 tRNA" gene complement(2677485..2677571) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /label="trnB-Leu1 gene" tRNA complement(2677582..2677657) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Lys tRNA" gene complement(2677582..2677657) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /label="trnB-Lys gene" tRNA complement(2677695..2677770) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Thr tRNA" gene complement(2677695..2677770) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /label="trnB-Thr gene" tRNA complement(2677803..2677878) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Val tRNA" gene complement(2677803..2677878) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /label="trnB-Val gene" rRNA complement(2677899..2678016) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-5S rRNA" gene complement(2677899..2678016) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /label="rrnB-5S gene" rRNA complement(2678072..2680999) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-23S rRNA" gene complement(2678072..2680999) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /label="rrnB-23S gene" rRNA complement(2681167..2682721) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-16S rRNA" gene complement(2681167..2682721) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /label="rrnB-16S gene" Polymorphism join(2682523,2682525) /Source="geneious" /ID="SNP_BsDelta6_3178443_3178443" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="T -> C" /Codon_Change /Coverage=95 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="3.5e-102" /Variant_Raw_Frequency=94 /comment="rrnB-16S rRNA" /modified_by="User" / /label="Polymorphism_Delta6" S_feature complement(2682722..2683013) /Source="Nicolas_S_feature" /locus_tag="new_3178641_3178932_c" /HighExp="Diami, LPhT, C30, LBGstat, HPh, GM 120, Oxctl, Paraq, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40784100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1181" misc_feature 2682849..2682857 /Source="Nicolas_upshift_promotors" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2682855 /Source="Nicolas_upshifts" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2682965 /Source="Nicolas_upshifts" /id="D1595" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="2.91899" /MaxDrop="4.63941" /score="-0.368124787" /energy="-10.2" /TU="U2400" /idTUdmin="U2400" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2682986..2683005) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2683013) /Source="Nicolas_upshifts" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2683015..2683981) /Source="Nicolas_S_feature" /locus_tag="new_3178934_3179900_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T0.0H, T3.0H, T-0.40H, S8, T3.30H" /AntisenseName="thiT" /AntisenseCor="-0.219467435413819" /AntisenseRegPval="-3.5" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1182" promotor_-35 complement(2683019..2683026) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2683138..2683141 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2683153 /Source="Nicolas_upshifts" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2683156..2683175 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2683186..2683287 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswC RNA" gene 2683186..2683287 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /label="tswC gene" downshifts 2683286 /Source="Nicolas_upshifts" /id="D1596" /incds=0 /nref=47 /ntot=135 /MaxReadThrough="5.85975" /MaxDrop="7.03111" /score="-0.368124787" /energy="-10.2" /TU="U2402" /idTUdmin="U2400" /TUdmin=299 /isTUend="FALSE" /label="downshifts" CDS 2683387..2683965 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 19181806" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 19181806; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamin permease" /protein_id="NP_390977.1" /db_xref="EnsemblGenomes-Gn:BSU30990" /db_xref="EnsemblGenomes-Tr:CAB15077" /db_xref="GOA:O32074" /db_xref="InterPro:IPR012651" /db_xref="SubtiList:BG13949" /db_xref="UniProtKB/Swiss-Prot:O32074" /translation="MNQSKQLVRLIEIAIMTAAAVILDIVSGMFLSMPQGGSVSIMMI PIFLISFRWGVKAGLTTGLLTGLVQIAIGNLFAQHPVQLLLDYIVAFAAIGISGCFAS SVRKAAVSKTKGKLIVSVVSAVFIGSLLRYAAHVISGAVFFGSFAPKGTPVWIYSLTY NATYMVPSFIICAIVLCLLFMTAPRLLKSDKA*" /label="thiT CDS" gene 2683387..2683965 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /label="thiT gene" downshifts 2683955 /Source="Nicolas_upshifts" /id="D1597" /incds=0 /nref=129 /ntot=206 /MaxReadThrough="1.91553" /MaxDrop="5.49387" /score="35.5376279" /energy="-19.5" /TU="NA" /idTUdmin="U2402" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2684007..2684528) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390978.1" /db_xref="EnsemblGenomes-Gn:BSU31000" /db_xref="EnsemblGenomes-Tr:CAB15078" /db_xref="GOA:O32075" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13948" /db_xref="UniProtKB/Swiss-Prot:O32075" /translation="MVTVREAKLEDIKDIAKVHVDSWRTTYHEIIPIDYLNSLNYKEF EDKWKSRSLKGVFVAQDEKGSVFGFASFGPIRSEQEGYDGELYAIYLLEERQRQGAGR ALLAKGAEFLLQHGFSSMFVWVIEQNPSIIFYQAYSPERVAEDNFEIAGVRLKEVGLG WPDLSALKTLLNR*" /label="yuaI CDS" gene complement(2684007..2684528) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /label="yuaI gene" downshifts complement(2684025) /Source="Nicolas_upshifts" /id="D1598" /incds=0 /nref=8 /ntot=143 /MaxReadThrough="6.18352" /MaxDrop="5.43101" /score="13.1646679" /energy="-19.6" /TU="U2403" /idTUdmin="U2405" /TUdmin=6 /isTUend="TRUE" /label="downshifts" downshifts complement(2684097) /Source="Nicolas_upshifts" /id="D1599" /incds=1 /nref=8 /ntot=208 /MaxReadThrough="8.2849" /MaxDrop="3.3545" /score="13.1646679" /energy="-19.6" /TU="U2403,U2405" /idTUdmin="U2405" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2684546..2686075) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /experiment="publication(s) with functional evidences, PMID:9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845; Product type s: structure" /codon_start=1 /transl_table=11 /product="flotillin lipid rafts scaffold protein" /protein_id="NP_390979.1" /db_xref="EnsemblGenomes-Gn:BSU31010" /db_xref="EnsemblGenomes-Tr:CAB15079" /db_xref="GOA:O32076" /db_xref="InterPro:IPR001107" /db_xref="InterPro:IPR027705" /db_xref="InterPro:IPR031905" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG13947" /db_xref="UniProtKB/Swiss-Prot:O32076" /translation="MTMPIIMIIGVVFFLLIALIAVFITKYRTAGPDEALIVTGSYLG NKNVHVDEGGNRIKIVRGGGTFVLPVFQQAEPLSLLSSKLDVSTPEVYTEQGVPVMAD GTAIIKIGGSIGEIATAAEQFLGKSKDDREQEAREVLEGHLRSILGSMTVEEIYKNRE KFSQEVQRVASQDLAKMGLVIVSFTIKDVRDKNGYLESLGKPRIAQVKRDADIATAEA DKETRIKRAEADKDAKKSELERATEIAEAEKINQLKMAEFRREQDTAKANADQAYDLE TARARQQVTEQEMQVKIIERQKQIELEEKEILRRERQYDSEVKKKADADRYSVEQSAA AEKAKQLAEADAKKYSIEAMAKAEAEKVRIDGLAKAEAEKAKGETEAEVIRLKGLAEA EAKEKIAAAFEQYGQAAIFDMIVKMLPEYAKQAAAPLSNIDKITVVDTGGSGESSGAN KVTSYATNLMSSLQESLKASSGIDVKEMLENFSGKGNVKQSINELTNEIKEAKTIQKS E*" /label="floT CDS" gene complement(2684546..2686075) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /label="floT gene" CDS complement(2686096..2686620) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12533473, 15849754, 16850406, 18696230, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane integrity integral membrane protein" /protein_id="NP_390980.1" /db_xref="EnsemblGenomes-Gn:BSU31020" /db_xref="EnsemblGenomes-Tr:CAB15080" /db_xref="GOA:O32077" /db_xref="PDB:2K14" /db_xref="SubtiList:BG13946" /db_xref="UniProtKB/Swiss-Prot:O32077" /translation="MELFGVPIQTMYLYTLIIAGSLTLLFLFFGDVFSGLSEGIPFLN PTLVLSFFTCFSAGGYIGELVLPLSSLLIALLSCILSIMLVVLLHIFVLVPLSSAEES LAYREDDLRGRLGKVITAVPVDGFGEVVIEGIGGTISKSAVSFDNQQISYGTTVLVVD INNGVLSVTPHEPI*" /label="nfeDB CDS" gene complement(2686096..2686620) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /label="nfeDB gene" promotor_-10 complement(2686664..2686679) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-10" upshifts complement(2686670) /Source="Nicolas_upshifts" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="upshifts" S_feature complement(2686672..2686759) /Source="Nicolas_S_feature" /locus_tag="new_3182591_3182678_c" /HighExp="S4, S8, S6, S7, S5, S3, B36, LoTm, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S1183" promotor_-35 complement(2686691..2686700) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-35" promotor_-10 complement(2686744..2686762) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2686754 /Source="Nicolas_upshifts" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2686758..2686777 /Source="Nicolas_upshift_promotors" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2686759) /Source="Nicolas_upshifts" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2686777..2686782) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2686788..2687276 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390981.1" /db_xref="EnsemblGenomes-Gn:BSU31030" /db_xref="EnsemblGenomes-Tr:CAB15081" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG13945" /db_xref="UniProtKB/Swiss-Prot:O32078" /translation="MSIFNEARLETWNELKGLSDEKLNQKPSAEEWSIREVLDHLKKI DMTAQKMLKERVKDAPIKEIEEKPLEVAQDRNNKRKAPSHLEPAHDFISGSQMKRELD VVREQLTAAIASLKEEDFERVLPHPVFQELTVRQWIDFIGHHEKRHLSQMKEIKEKIE RA*" /label="yuaE CDS" gene 2686788..2687276 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /label="yuaE gene" downshifts 2687253 /Source="Nicolas_upshifts" /id="D1600" /incds=0 /nref=205 /ntot=267 /MaxReadThrough="4.05856" /MaxDrop="6.05192" /score="-4.20632485" /energy="-15" /TU="U2404" /idTUdmin="U2404" /TUdmin="-354" /isTUend="FALSE" /label="downshifts" CDS complement(2687282..2687860) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11886751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390982.1" /db_xref="EnsemblGenomes-Gn:BSU31040" /db_xref="EnsemblGenomes-Tr:CAB15082" /db_xref="GOA:O32079" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="PDB:1ORU" /db_xref="SubtiList:BG13944" /db_xref="UniProtKB/Swiss-Prot:O32079" /translation="MWKRMTAKAEGLYIADTKSFVTKQMDKLDFDYGGIPGDLHFGLT KKAGAREPMFSRGTEIFNRRQISIVSIEECNEIALKMGVPRILPEWLGANVAVSGMPD LTSLKEGSRIIFPSGAALLCEGENDPCIQPGEVIQSYYPDQPKLASAFVRHALGIRGI VCIVERPGAVYTGDEIEVHSYQRKVKRKAERV*" /label="yuaD CDS" gene complement(2687282..2687860) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /label="yuaD gene" S_feature 2687298..2687689 /Source="Nicolas_S_feature" /locus_tag="new_3183217_3183608" /HighExp="Etha, S8, LPhT, S6, Salt, LoTm, S5, H2O2, S7, dia5" /AntisenseName="yuaD" /AntisenseCor="-0.48344313728748101" /AntisenseRegPval="-16.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S1184" downshifts complement(2687309) /Source="Nicolas_upshifts" /id="D1601" /incds=0 /nref=87 /ntot=222 /MaxReadThrough="0.58189" /MaxDrop="3.9885" /score="0.718873117" /energy="-11.5" /TU="NA" /idTUdmin="U2406" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2687894..2687913) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2687903) /Source="Nicolas_upshifts" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2687927..2687934) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2687948..2689156) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /EC_number="1.1.99.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="choline dehydrogenase" /protein_id="NP_390983.2" /db_xref="EnsemblGenomes-Gn:BSU31050" /db_xref="EnsemblGenomes-Tr:CAB15083" /db_xref="GOA:P71017" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG11941" /db_xref="UniProtKB/Swiss-Prot:P71017" /translation="MTLNMKVESMQKFHTFEIPTVIKHGIGAIKHTGEEVAALGVSKA LLVTDPGIYKAGVADPVIESLKEAGIEVVLFNKVEPNPPVRLVNEGSELYKKENCNGL VAVGGGSSMDTAKAIGVEATHEGSVLDYEAADGKKPLENRIPPLTTIPTTAGTGSEVT QWAVITDEEREFKFNTGGPLIAAHLTIIDPELHVSMPPHVTAMTGIDALAHAIECYTM KFAQPITDAVALMAIEYAAHYIKRAFADGEDLEARYGMAQAAMLAGLSYGSESAGAAH AMSQTLGGIIPVAHGQCVAAMMGPVMEYNWKGYPEKFARIAKAFGIDTSKMTTEEAAK ASVNWMYDLVEDLEVPTLEEQGVSPDMIERLSKEAMKDPQTFGNPRDLNEKAYNWIYK RCFNLTPKTV*" /label="gbsB CDS" gene complement(2687948..2689156) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /label="gbsB gene" downshifts complement(2687969) /Source="Nicolas_upshifts" /id="D1602" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="2.9443" /MaxDrop="3.26923" /score="18.315772" /energy="-13.6" /TU="NA" /idTUdmin="U2406" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2688925..2688944) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2688937) /Source="Nicolas_upshifts" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2688959..2688966) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2689173..2690645) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /EC_number="1.2.1.8" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 9297465, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 9297465, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine betaine aldehyde dehydrogenase, NAD+-dependent" /protein_id="NP_390984.1" /db_xref="EnsemblGenomes-Gn:BSU31060" /db_xref="EnsemblGenomes-Tr:CAB15084" /db_xref="GOA:P71016" /db_xref="InterPro:IPR011264" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11940" /db_xref="UniProtKB/Swiss-Prot:P71016" /translation="MSQTLFIDGEWISAEKEQIRSIINPFNQEEIATVSEGGREDAIK AIAAARRAFDKGEWSSLSGLERGKIVLKIAELIRRDLEELAELESLDTGKTLEESKAD MDDIANVFQYYAGLADKDGGEIISSPIPDSESKIIREPIGVCGQITPWNYPLLQASWK IAPALAAGNTIVMKPSEITPLTTIKVFKLMEEAGVPKGVANLVLGPGATVGDELAVNK DVDLISFTGGIETGKKIMRAASGNVKKIALELGGKNPNIVFKDADLEVAVDQALNAVF FHAGQVCSAGSRLLVEDAIHDQFLAELVKRAKRIKLGNGFHAETESGPLISAEHRAKV EKYVEIGIEEGAKLETGGKRPEDPELQNGFFYEPTIFSNCNSDMRIVQEEVFGPVLTV ETFSSEEEVIELANDTIYGLAGAVWSKDIEKCERVAARLRMGTVWINDFHPYFAQAPW GGYKQSGFGRELGKIGLEEYTEVKHVYRNTKPAAVNWFNS*" /label="gbsA CDS" gene complement(2689173..2690645) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /label="gbsA gene" promotor_-10 complement(2690696..2690715) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2690697) /Source="Nicolas_upshifts" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2690730..2690737) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2690757..2690763 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2690777..2690796 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2690792 /Source="Nicolas_upshifts" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="upshifts" CDS 2690844..2691386 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor for gbsAB" /protein_id="NP_390985.1" /db_xref="EnsemblGenomes-Gn:BSU31070" /db_xref="EnsemblGenomes-Tr:CAB15085" /db_xref="GOA:P71015" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12342" /db_xref="UniProtKB/Swiss-Prot:P71015" /translation="MDENPEFAAIEQARDLVIDSIAETMDLYGITRSVGILYGTMYMR DEMTLDEMREELQMSKPSMSTGVKKLQDLNVVKKTFHRGIRKHTFVAEKDFFKFFTNF FPPKWEREVQVNVTAIEEAQADLQKVLCKEDLDEDIKNEALQLYDQLESSKAYYDWLK RLAESVQTGEIFKFIPVETK*" /label="gbsR CDS" gene 2690844..2691386 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /label="gbsR gene" downshifts 2691369 /Source="Nicolas_upshifts" /id="D1603" /incds=0 /nref=74 /ntot=220 /MaxReadThrough="1.70461" /MaxDrop="3.5918" /score="26.1509691" /energy="-9.9" /TU="NA" /idTUdmin="U2409" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2691463..2691470 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2691483..2691583 /Source="Nicolas_S_feature" /locus_tag="new_3187402_3187502" /HighExp="BT, S0, BI, T-1.10H, T-1.40H, T1.0H, T-0.40H, T0.0H, S2, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1185" upshifts 2691483 /Source="Nicolas_upshifts" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2691485..2691504 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2691584..2692129 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /function="15.3: Cell adhesion" /experiment="publication(s) with functional evidences, PMID:21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732; Product type s: structure" /codon_start=1 /transl_table=11 /product="biofilm hydrophobic layer component" /protein_id="NP_390986.1" /db_xref="EnsemblGenomes-Gn:BSU31080" /db_xref="EnsemblGenomes-Tr:CAB15086" /db_xref="GOA:P71014" /db_xref="InterPro:IPR034650" /db_xref="PDB:4BHU" /db_xref="SubtiList:BG12341" /db_xref="UniProtKB/Swiss-Prot:P71014" /translation="MKRKLLSSLAISALSLGLLVSAPTASFAAESTSTKAHTESTMRT QSTASLFATITGASKTEWSFSDIELTYRPNTLLSLGVMEFTLPSGFTANTKDTLNGNA LRTTQILNNGKTVRVPLALDLLGAGEFKLKLNNKTLPAAGTYTFRAENKSLSIGNKFY AEASIDVAKRSTPPTQPCGCN*" /label="bslA CDS" gene 2691584..2692129 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /label="bslA gene" downshifts 2692116 /Source="Nicolas_upshifts" /id="D1604" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="0.85027" /MaxDrop="6.00835" /score="20.8976757" /energy="-10.2" /TU="NA" /idTUdmin="U2410" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2692221..2692228 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2692242..2692261 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2692249 /Source="Nicolas_upshifts" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 2692254..2692422 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /product="cyclic-di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751; Product type n: RNA" /label="swdA RNA" gene 2692254..2692422 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /label="swdA gene" downshifts 2692403 /Source="Nicolas_upshifts" /id="D1605" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="6.04086" /MaxDrop="4.75274" /score="3.29445061" /energy="-6.1" /TU="U2411" /idTUdmin="U2410" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 2692495..2693163 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 23598340, 23671116, 25957408, 26771197" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 23598340, 23671116, 25957408, 26771197; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_390987.1" /db_xref="EnsemblGenomes-Gn:BSU31090" /db_xref="EnsemblGenomes-Tr:CAB15087" /db_xref="GOA:O32080" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="PDB:1LSU" /db_xref="PDB:2HMS" /db_xref="PDB:2HMT" /db_xref="PDB:2HMU" /db_xref="PDB:2HMV" /db_xref="PDB:2HMW" /db_xref="PDB:4J7C" /db_xref="PDB:4J90" /db_xref="PDB:4J91" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13943" /db_xref="UniProtKB/Swiss-Prot:O32080" /translation="MGRIKNKQFAVIGLGRFGGSICKELHRMGHEVLAVDINEEKVNA YASYATHAVIANATEENELLSLGIRNFEYVIVAIGANIQASTLTTLLLKELDIPNIWV KAQNYYHHKVLEKIGADRIIHPEKDMGVKIAQSLSDENVLNYIDLSDEYSIVELLATR KLDSKSIIDLNVRAKYGCTILAIKHHGDICLSPAPEDIIREQDCLVIMGHKKDIKRFE NEGM*" /label="ktrA CDS" gene 2692495..2693163 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /label="ktrA gene" CDS 2693170..2694507 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium transporter ATPase" /protein_id="NP_390988.1" /db_xref="EnsemblGenomes-Gn:BSU31100" /db_xref="EnsemblGenomes-Tr:CAB15088" /db_xref="GOA:O32081" /db_xref="InterPro:IPR003445" /db_xref="InterPro:IPR004772" /db_xref="PDB:4J7C" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13956" /db_xref="UniProtKB/Swiss-Prot:O32081" /translation="MTLQKDKVIKWVRFTPPQVLAIGFFLTIIIGAVLLMLPISTTKP LSWIDALFTAASATTVTGLAVVDTGTQFTVFGQTVIMGLIQIGGLGFMTFAVLIVMIL GKKIGLKERMLVQEALNQPTIGGVIGLVKVLFLFSISIELIAALILSIRLVPQYGWSS GLFASLFHAISAFNNAGFSLWPDNLMSYVGDPTVNLVITFLFITGGIGFTVLFDVMKN RRFKTFSLHTKLMLTGTLMLNAIAMLTVFILEYSNPGTLGHLHIVDKLWASYFQAVTP RTAGFNSLDFGSMREGTIVFTLLLMFIGAGSASTASGIKLTTFIVILTSVIAYLRGKK ETVIFRRSIKYPIIIKALAVSVTSLFIVFLGIFALTITEQAPFLQIVFETFSAFGTVG LTMGLTPELTTAGKCIIIVIMFIGRIGPLTFVFSFAKTEQSNIRYPDGEVFTG*" /label="ktrB CDS" gene 2693170..2694507 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /label="ktrB gene" downshifts 2694493 /Source="Nicolas_upshifts" /id="D1606" /incds=0 /nref=9 /ntot=98 /MaxReadThrough="0.86883" /MaxDrop="3.37604" /score="25.8974852" /energy="-11.9" /TU="NA" /idTUdmin="U2411" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2694543..2694806) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390989.1" /db_xref="EnsemblGenomes-Gn:BSU31110" /db_xref="EnsemblGenomes-Tr:CAB15089" /db_xref="GOA:O32082" /db_xref="InterPro:IPR008024" /db_xref="SubtiList:BG13955" /db_xref="UniProtKB/Swiss-Prot:O32082" /translation="MQKYRRRNTVAFTVLAYFTFFAGVFLFSIGLYNADNLELNEKGY YIAVMILVAVGAILTQKVTRDNAEDNEIIAEQEKRQNQSHIES*" /label="yubF CDS" gene complement(2694543..2694806) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /label="yubF gene" downshifts complement(2694561) /Source="Nicolas_upshifts" /id="D1607" /incds=0 /nref=237 /ntot=309 /MaxReadThrough="2.4577" /MaxDrop="7.13564" /score="30.2020977" /energy="-11.9" /TU="NA" /idTUdmin="U2412" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2694846..2694865) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2694848) /Source="Nicolas_upshifts" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2694878..2694885) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2694915..2695763) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /EC_number="3.2.1.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12525152, 16855244, 28448118, 28811162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12525152, 16855244, 28448118, 28811162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exoglucosaminidase" /protein_id="NP_390990.1" /db_xref="EnsemblGenomes-Gn:BSU31120" /db_xref="EnsemblGenomes-Tr:CAB15090" /db_xref="GOA:O32083" /db_xref="InterPro:IPR002901" /db_xref="InterPro:IPR025987" /db_xref="SubtiList:BG13954" /db_xref="UniProtKB/Swiss-Prot:O32083" /translation="MARKKLKKRKLLISLFFLVSIPLALFVLATTLSKPIEISKETEE IDEQQVFIDSLSGHAQILYEKYHVLPSITIAQAILESDWGNSELAAKANNLFGVKGNY KGHHVTMETDEVEKGKRKTIRAKFRKYSTFFESMDDHAQLFVRGTSWNKKKYKPVLEA GNYKEAATALQTSGYATDPDYADKISAIVEKYDLDEYDEVNPSLKSVDLNASIKDSAV QDVWSKPSTDDRSIRLTSAQSYVGKDIKVVSKKQKGQSVWYQFQINDKLIGWIDDSAV EIKEAT*" /label="lytG CDS" gene complement(2694915..2695763) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /label="lytG gene" promotor_-10 complement(2695808..2695827) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2695818) /Source="Nicolas_upshifts" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2695842..2695849) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2695924..2697459) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28248504; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390991.1" /db_xref="EnsemblGenomes-Gn:BSU31130" /db_xref="EnsemblGenomes-Tr:CAB15091" /db_xref="GOA:O32084" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13953" /db_xref="UniProtKB/Swiss-Prot:O32084" /translation="MKTKHYWVISLLAVLAVGPGLMSNTALSSVQGLVQKTVGTSVFT SVNPILIGNMAFALLVPAGPLLRKKFGARPVYLASLPVFILGSLLIACSGDIALMAAG RFLQGAATGVMLMIMIPMLVLSFPIERRNYALLVLIGGFYGSVIIGTILGTIATSCGH WRWLFFIFGTLSLIGVAVSYFFLHDEHHGAADQEQPLDRAGILLSVFLAAASAVSFIF LQKWGLSSGYVWIGFGVTLCLLIGLLIVEYKVKNPFISIKLMLLPKPVLGLLIIAAGT ITVAVSLSAFQGLLRQMYDISQEHLILLSLTLLIGVAIAAILSALLYDKVGPGMLGII GGLILVFVNFQWLHIQDRSSLYMFAALFIMLAAGTGLTVAAGLMGAAMGGPLPDLVKR MTAVQFLRLFVYMGVPILIGFFTKKDAARQSGSVQDSMMTAYHDLFFISFILSVLLVC LSFCMNATGMGHKLAHKPHDKAKTAPEKPAVSAQGLSKATVKSYKVINDTEYRNALRN LQK*" /label="yubD CDS" gene complement(2695924..2697459) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /label="yubD gene" downshifts complement(2695933) /Source="Nicolas_upshifts" /id="D1608" /incds=0 /nref=45 /ntot=159 /MaxReadThrough="1.39941" /MaxDrop="4.26166" /score="-3.3162201" /energy="-5.7" /TU="NA" /idTUdmin="U2415" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 2697117..2697217 /Source="Nicolas_upshift_promotors" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2697177 /Source="Nicolas_upshifts" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2697243 /Source="Nicolas_upshifts" /id="D1609" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="0.0870599999999992" /MaxDrop="3.19459" /score="-1.6836786" /energy="-10.4" /TU="NA" /idTUdmin="U2416" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" S_feature complement(2697460..2697627) /Source="Nicolas_S_feature" /locus_tag="new_3193379_3193546_c" /HighExp="Cold, S8, G180, UNK1, C30, G135, S7, Lbexp, MG 25, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34877900000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1186" promotor_-10 complement(2697616..2697635) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2697627) /Source="Nicolas_upshifts" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2697629..2698506) /Source="Nicolas_S_feature" /locus_tag="new_3193548_3194425_c" /HighExp="G180, Cold, C30, G135, Paraq, Oxctl, S8, G150, H2O2, Heat" /AntisenseName="cdoA" /AntisenseCor="-2.3104546834536201E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1187" promotor_-35 complement(2697650..2697657) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2697869..2697878 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2697892..2697911 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2697892 /Source="Nicolas_upshifts" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="upshifts" CDS 2697944..2698429 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /EC_number="1.13.11.20" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10939241, 15699190, 16855246, 25307852, 26590284" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15699190, 16855246, 25307852, 26590284; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine dioxygenase" /protein_id="NP_390992.1" /db_xref="EnsemblGenomes-Gn:BSU31140" /db_xref="EnsemblGenomes-Tr:CAB15092" /db_xref="GOA:O32085" /db_xref="InterPro:IPR010300" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:3EQE" /db_xref="PDB:4QM8" /db_xref="PDB:4QM9" /db_xref="SubtiList:BG13952" /db_xref="UniProtKB/Swiss-Prot:O32085" /translation="MELYECIQDIFGGLKNPSVKDLATSLKQIPNAAKLSQPYIKEPD QYAYGRNAIYRNNELEIIVINIPPNKETTVHDHGQSIGCAMVLEGKLLNSIYRSTGEH AELSNSYFVHEGECLISTKGLIHKMSNPTSERMVSLHVYSPPLEDMTVFEEQKEVLEN S*" /label="cdoA CDS" gene 2697944..2698429 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /label="cdoA gene" S_feature 2698430..2698716 /Source="Nicolas_S_feature" /locus_tag="new_3194349_3194635" /HighExp="S6, S8, S7, BT, S5, G/S, C30, Pyr, C90, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.53171800000000002" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1188" tRNA complement(2698536..2698608) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala (GGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /label="trnSL-Ala1 tRNA" gene complement(2698536..2698608) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /label="trnSL-Ala1 gene" downshifts complement(2698551) /Source="Nicolas_upshifts" /id="D1610" /incds=0 /nref=37 /ntot=180 /MaxReadThrough="3.88031" /MaxDrop="4.38957" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts complement(2698595) /Source="Nicolas_upshifts" /id="D1611" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.34085" /MaxDrop="4.19639" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=110 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2698619..2698638) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2698639) /Source="Nicolas_upshifts" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2698653..2698656) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2698673 /Source="Nicolas_upshifts" /id="D1612" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="3.04964" /MaxDrop="3.22361" /score="-1.6836786" /energy="-10.4" /TU="U2416" /idTUdmin="U2416" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2698716..2699546) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /EC_number="3.6.1.27" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15138271, 15849754, 16850406, 27528508, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15138271, 15849754, 16850406, 27528508, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl-pyrophosphate phosphatase" /protein_id="NP_390993.1" /db_xref="EnsemblGenomes-Gn:BSU31150" /db_xref="EnsemblGenomes-Tr:CAB15093" /db_xref="GOA:P94507" /db_xref="InterPro:IPR003824" /db_xref="SubtiList:BG13951" /db_xref="UniProtKB/Swiss-Prot:P94507" /translation="MTLWELFVAAILGIVEGLTEYAPVSSTGHMIIVDDIWLKSSNLM SEEAANSFKVVIQLGSILAVAIVFKDRILNLLGLKKNITSDQEQGHKLSIAQIAVGLV PAAVLGFLFEDYIDEYLFSVKTVAIGLIAGAILMLFADWVNKRKTATDTLDRISYKQA IAVGLFQCLSLWPGFSRSGSTISGGVILGLNHRAAADFTFIMAMPIMMGASFLSLVKH WDSLSSDLMPFFIVGFICAFVVALFVVRFFLRLINKIKLVPFAIYRIILGVILLLIMM *" /label="uppP CDS" gene complement(2698716..2699546) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /label="uppP gene" downshifts complement(2698727) /Source="Nicolas_upshifts" /id="D1613" /incds=0 /nref=60 /ntot=208 /MaxReadThrough="3.0552" /MaxDrop="5.61932" /score="-4.25033697" /energy="-6.7" /TU="U2419" /idTUdmin="U2419" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2699547..2699638) /Source="Nicolas_S_feature" /locus_tag="new_3195466_3195557_c" /HighExp="dia15, H2O2, Salt, Etha, dia5, LBGtran, M0t90, Lbstat, Mt0, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1189" CDS complement(2699639..2700805) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16385049, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390994.1" /db_xref="EnsemblGenomes-Gn:BSU31160" /db_xref="EnsemblGenomes-Tr:CAB15094" /db_xref="GOA:O32086" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13950" /db_xref="UniProtKB/Swiss-Prot:O32086" /translation="METLQTWSGRFKRFFLDNKFVLFLLVLLLIGLNILVFTKTSFIF TPIIVLLKTISLPIILTGIVFYLLNPVVDFLERRRIRRIYSILLLYLLVIGLITITIV SIIPFLKEQIMSLIDNIPRYVDVVENQTKQLIGSNFVNQAQQTMNINISDLATKVSDQ AATIVNSTFTGVGNFIGALTEIIISIVTVPFILFYLLKDGRKLPVYILKFVPTRLKEQ TYTVLSEMNHRLSSYIRGQIIVSFCIGFLLFIGYLIIGLDYASLLAVIAACTSIVPYL GPTIAITPAIIIAIVTSPLMLLKLVIVWTIVQLIEGKLISPQIMGKNLHIHPITIIFL LLTAGKLFGVVGIILAIPGYAVAKVITTHLFDWFKMQSHLYDEEKNENTPGHKV*" /label="yubA CDS" gene complement(2699639..2700805) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /label="yubA gene" promotor_-35 2700801..2700805 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2700813..2700827 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2700829..2700848) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2700829 /Source="Nicolas_upshifts" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2700848) /Source="Nicolas_upshifts" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2700862..2700869) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2700927..2700934 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2700940 /Source="Nicolas_upshifts" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2700945..2700964 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2700987..2701973 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" /EC_number="1.1.1.371" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12450853, 28043209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450853, 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol dehydrogenase (NADP+-dependent);biofilm formation" /protein_id="NP_390995.1" /db_xref="EnsemblGenomes-Gn:BSU31170" /db_xref="EnsemblGenomes-Tr:CAB15095" /db_xref="GOA:O05265" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12388" /db_xref="UniProtKB/Swiss-Prot:O05265" /translation="MIRFAIIGTNWITDRFLESAADIEDFQLTAVYSRSAERAGEFAA KHNAAHAFSDLQEMAASDCFDAVYIASPNALHKEQAVLFMNHGKHVLCEKPFASNTKE TEEMISAAKANGVVLMEAMKTTFLPNFKELKKHLHKIGTVRRFTASYCQYSSRYDAFR SGTVLNAFQPELSNGSLMDIGVYCIYPAVVLFGAPKDVKANGYALSSGVDGEGTVILS YDGFEAVLMHSKISTSYAPAEIQGEDGTIVIDTIHRPERVEIRYRDGRLENIAIPDPK PAMFYEAEEFVTLIKENKLESEENTFERSLTTAKIMEEARKQMGIVYPADQA*" /label="iolU CDS" gene 2700987..2701973 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" /label="iolU gene" downshifts 2701944 /Source="Nicolas_upshifts" /id="D1614" /incds=0 /nref=30 /ntot=279 /MaxReadThrough="1.83109" /MaxDrop="4.96985" /score="21.8997198" /energy="-15.1" /TU="NA" /idTUdmin="U2420" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2702014..2703288) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" /EC_number="5.3.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960106, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960106, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose isomerase" /protein_id="NP_390996.1" /db_xref="EnsemblGenomes-Gn:BSU31180" /db_xref="EnsemblGenomes-Tr:CAB15096" /db_xref="GOA:O05264" /db_xref="InterPro:IPR009308" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG12387" /db_xref="UniProtKB/Swiss-Prot:O05264" /translation="MTIKANYDSAKQAYEKWGIDVEEALRQLEQVPISIHCWQGDDIE GFEVNKGELSGGIDVTGNYPGKAQTPEELRRDLEKALSLIPGKHRVNLHAIYAETNRE AVERDELKPQHFENWVKWAKNLGLGLDFNPTLFSHEKAADGLTLSHPDPDIREFWIRH CIACRRIGEYFGKELGTPCLTNIWIPDGYKDIPSDRLTPRKRLKESLDRIFSEEISEQ HNLDSIESKLFGLGSESYVVGSHEFYLAYALTNHKLCLLDTGHFHPTETVSNKISSML LYTDKLALHVSRPVRWDSDHVVVLDDELREIALEIVRNHALEKVAIGLDFFDASINRV AAWTIGTRNMIKALLYALLLPNGYLKQLQEEGRYTERLALMEEFKTYPFGAIWDSYCE QMGVPVKEAWLYDIKEYEQQVLLKRKASSPIV*" /label="rhaA CDS" gene complement(2702014..2703288) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" /label="rhaA gene" downshifts complement(2702027) /Source="Nicolas_upshifts" /id="D1615" /incds=0 /nref=3 /ntot=29 /MaxReadThrough="0.802" /MaxDrop="4.45322" /score="14.0829844" /energy="-12.6" /TU="NA" /idTUdmin="U2421" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2703314..2703628) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" /EC_number="5.1.3.32" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15576793, 15876375, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576793, 15876375, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose mutarotase" /protein_id="NP_390997.1" /db_xref="EnsemblGenomes-Gn:BSU31190" /db_xref="EnsemblGenomes-Tr:CAB15097" /db_xref="GOA:O05263" /db_xref="InterPro:IPR008000" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR013448" /db_xref="SubtiList:BG12386" /db_xref="UniProtKB/Swiss-Prot:O05263" /translation="MKRKASIMFVHQDKYEEYKQRHDDIWPEMAEALKAHGAHHYSIF LDEETGRLFAYLEIEDEEKWRKMADTEVCQRWWKSMAPLMKTNSDFSPVAIDLKEVFY LD*" /label="rhaM CDS" gene complement(2703314..2703628) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" /label="rhaM gene" CDS complement(2703646..2705103) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" /EC_number="2.7.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16674975, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16674975, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnulokinase" /protein_id="NP_390998.1" /db_xref="EnsemblGenomes-Gn:BSU31200" /db_xref="EnsemblGenomes-Tr:CAB15098" /db_xref="GOA:O05262" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR013449" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG12385" /db_xref="UniProtKB/Swiss-Prot:O05262" /translation="MIYTAIDVGASSGRIMVGELNEGKLDIQEIHRFANGFSQRDGHC LWDIDHLLKQILQGLQKVKTLGYEHCTVGIDTWAVDYVLLDEKGDRLREAISYRDRRT DHTIDKLEHTLSKAAIYQKTGIQFQPFNTIYQLFEEDRELLKKTDKIMMIPDYLGYCL TGKAVTEITNVSTTQLLNVSTGNLDPELLEAVSVLEQQFAPLTEPGCELGKLRNEWFP DYDLPACKVMTVATHDTASAVIAAPGVNDGWAYISSGTWSLIGVENKTPIITDLALEN NYTNERGANNTIRFLKNIIGMWVIQEVKQQLQADYSFQQLAEEAKKTEPFQQFINLND KRFLNPENMIKEIQHYCRQTRQKIPRTAGELACCIYSNLAIIYAIAIKELETITEKPI EQFHIIGGGARNDFLNQLTADMSGKAVYAGPIEATATGNLLMQMIAAKEVKDIKEARQ VVRNSFPIKVFTPKDIDRSTIIQSFQQTVLKALSK*" /label="rhaB CDS" gene complement(2703646..2705103) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" /label="rhaB gene" CDS complement(2705108..2705884) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11496004, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11496004, 26712933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the rhamnose operon(RhaR / l-rhamnulose-1-phosphate)" /protein_id="NP_390999.1" /db_xref="EnsemblGenomes-Gn:BSU31210" /db_xref="EnsemblGenomes-Tr:CAB15099" /db_xref="GOA:O05261" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12384" /db_xref="UniProtKB/Swiss-Prot:O05261" /translation="MLVAERQQKIVEIVNMRSSIRVSELSDIFSVTEETIRRDLEKLE KEHKLSRSHGGAVSIQQKESEIHFSEREITNVIEKKAIAHEAAKYVKSGDRIILDAST TAWYMAKILPDIELTVITNSMKAAIELSNKENISVISTGGILLEKSLSFAGPLAERSL ETYHVNKTFLSCKGFDVHNGMSDSNEWQALLKKRMIERSDQTILMADSSKWGNREFSH IASLQDVSRLITDSGLDPASVKALEDKKVKVTAVPLSKRG*" /label="rhaR CDS" gene complement(2705108..2705884) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" /label="rhaR gene" misc_feature complement(2705918..2705937) /Source="Nicolas_upshift_promotors" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2705934) /Source="Nicolas_upshifts" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2705941..2708010) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" /EC_number="1.1.1.-" /EC_number="4.1.2.19" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24391637, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24391637, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional rhamnulose-1-phosphate aldolase/alcohol dehydrogenase" /protein_id="NP_391000.1" /db_xref="EnsemblGenomes-Gn:BSU31220" /db_xref="EnsemblGenomes-Tr:CAB15100" /db_xref="GOA:P40747" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR013454" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG10947" /db_xref="UniProtKB/Swiss-Prot:P40747" /translation="MVKHIWDSERAAQLPKGVEELVYRSNLIGSDRTVCNWGGGNTSM KTTEKDFRGREIEVMWVKGSGSDLATMKAHNFSGLKLDDIRPLIKRDQMPDEEMVDYL SHCMIDSKHPRPSIETLLHAFLPYKHVDHTHPDAIISICCADNGKQIAEDIYGNRFVW VPYVRPGFTLSKMIAEGVANNPHAELVLMEKHGLVTWGETSETCYQKTISIIQEAEQY INDRINQHEVFGGKRYQPLPEDKRKQILAGIMPVIRGAVSEEKKMILSYDDHDDVLEF VNSVQAPALSQIGAACPDHLVHTKRVPLYIDWNPETQDVHKLADLIKSGVETFTSEYQ AYFTRNQQDGDQIFESAPRVILIPGIGMVNTGKSYAMSKVSGALYRRAIAVMKGATAL GQFVSLHENESYHVEYWPLELYKLTLAPPEAEFSRKVALITGGAGGIGSAACRRFAAE GGHVIVADLNIEGAQKIAGEINDAYGKGRAMAVKMDVTKEEDVQSAFERAALAYGGID IVVNNAGLATSSPFDETSLKEWNLNMNVLGTGYFLVAREAFKQMKHQNRGGSMVFVGS KNSVYAGKNASAYSSVKALETHLARCIAAEGGEFGIRVNSVLPDAVLQGSAIWGSSWR EERAAAYGIEPDQLEEHYRKRTALLVNIYPEDIAEAIAFFASSKAEKTTGCMITVDGG VPAAFTR*" /label="rhaE CDS" gene complement(2705941..2708010) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" /label="rhaE gene" promotor_-10 complement(2708043..2708062) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2708055) /Source="Nicolas_upshifts" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2708076..2708082) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2708148..2710136) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391001.1" /db_xref="EnsemblGenomes-Gn:BSU31230" /db_xref="EnsemblGenomes-Tr:CAB15101" /db_xref="GOA:P39217" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10862" /db_xref="UniProtKB/Swiss-Prot:P39217" /translation="MGKFIQWIKQPSISKPLIAAFLAVLILPVGVLAYFSYQSAWNAL DRELISSAKGNVEELNSTLQNKLEDKVKAIDYYSETVDKDILLGKNKTLLKEKFKQYT TLNDDVGAIYAASEDKKLYKYPDSGVPKGFDPTGRDWYKQAVAEKGQAVFSEPYTDEA TGDIVVTISKQLKDGSGVIALDLNLDEVLTASKRIKIGKEGFAFITTGNKKYIAHPTI KPGTTGSGDWTNQVYSKKEGSFEYTFEGKEKKMAFTTNKLTGWKIAGTYFVSELQDAS SPVLNTAVIILCVSIVIGGILILYIIRAITKPLRKLVSTSAKISSGDLTEVIDIHSKN EFGQLGESFNEMSASLRSVIGVIQTSVENVASSSEELTASAAQTSKATEHITLAIEQF SDGNEAQSEKLETSSNHLSQMNEGISKVAQASSTITKSSIQSSEAAGSGEKLVEHTVG QMKTIDQSVQKAEAVVKGLETKSQDITSILNVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIQEIVREISTSLSMFQSVNHEVKEGLQITDQ TAESFKQIYEMTTQISGELQNLNATVEQLSAGSQEVSSAVEDISAVAKESSAGIQDIA ASAEEQLASMEEISSSAETLANMAEELQDITKKFKIES*" /label="tlpB CDS" gene complement(2708148..2710136) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" /label="tlpB gene" downshifts complement(2708167) /Source="Nicolas_upshifts" /id="D1616" /incds=0 /nref=108 /ntot=174 /MaxReadThrough="3.32915" /MaxDrop="6.75141" /score="18.7221191" /energy="-8.3" /TU="NA" /idTUdmin="U2423" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2710140..2710147 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2710157..2710175) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2710163..2710182 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2710170) /Source="Nicolas_upshifts" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="upshifts" upshifts 2710179 /Source="Nicolas_upshifts" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2710189..2710196) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2710245 /Source="Nicolas_upshifts" /id="D1617" /incds=0 /nref=4 /ntot=11 /MaxReadThrough="1.04089" /MaxDrop="4.2056" /score="13.4355481" /energy="-10.7" /TU="NA" /idTUdmin="U2424" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(2710250..2712235) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 9721285, 12011078" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 9721285, 12011078; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391002.2" /db_xref="EnsemblGenomes-Gn:BSU31240" /db_xref="EnsemblGenomes-Tr:CAB15102" /db_xref="GOA:P39214" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10861" /db_xref="UniProtKB/Swiss-Prot:P39214" /translation="MKKILQLIKQRSITRKLLVSFLSILIIPVVILAIFAYQSASSSL DRQMMGSALENVQQLNEIINTSIGEKENSADYFSEWLTKEKYNAKSNASIAEKFSQYI SINKDVESIYTSDTKGHFTRYPDLPMPSGYNPVERDWYKKAVANKGKVVITDPYKTAS TNTMVVTIAQQTKDGSGVIAINMTIENLLKTTKKVNIGTQGYAFIMTKDKKVVAHPNE QSGTELKGDWLDKMLSADKGDFQYTMDGDKKKMAFDTNKLTGWKIGGTMYLDEIHEAA QPVLHLALIVLAAAIIIGIIVMTLIIRSITTPLKQLVGSSKRISEGDLTETIDIRSKD ELGELGKSFNNMASSLRSLIHAIQDSVDNVAASSEELTASAAQTSKATEHITLAIEQF SNGNEKQNENIETAAEHIYQMNDGLTNMAQASEVITDSSVQSTEIASEGGKLVHQTVG QMNVIDKSVKEAEQVVRGLETKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIIEIVKEINTSLGMFQSVNQEVQTGLDITDK TEMSFKRISEMTNQIAGELQNMSATVQQLSASSEEVSGASEHIASISKESSAHIQDIA ASAEEQLASMEEISSSAETLSSMAEELRDMTKRFKIE*" /label="mcpA CDS" gene complement(2710250..2712235) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" /label="mcpA gene" downshifts complement(2710255) /Source="Nicolas_upshifts" /id="D1618" /incds=0 /nref=196 /ntot=232 /MaxReadThrough="3.11319" /MaxDrop="7.54297" /score="40.6270404" /energy="-13.6" /TU="U2425" /idTUdmin="U2425" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2712256..2712274) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2712271) /Source="Nicolas_upshifts" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2712273..2712360) /Source="Nicolas_S_feature" /locus_tag="new_3208192_3208279_c" /HighExp="GM 150, T0.0H, T-1.40H, T-0.40H, MG 150, T-5.40H, T-3.40H, T-1.10H, T-2.40H, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1190" promotor_-35 complement(2712288..2712295) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2712361..2714349) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871, 26522943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871, 26522943; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (membrane curvature dependent localisation)" /protein_id="NP_391003.1" /db_xref="EnsemblGenomes-Gn:BSU31250" /db_xref="EnsemblGenomes-Tr:CAB15103" /db_xref="GOA:P39216" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10860" /db_xref="UniProtKB/Swiss-Prot:P39216" /translation="MKKTLTTIRRSSIARRLIISFLLILIVPITALSVSAYQSAVASL DVQMTQSAKENVQILDHIIDDKISTTEKSLAYFSDWATAEKFQDKKKTELKQEFKQFI QMNDNVAAVFSSGKDGDFTRYPYADMPSDFNALERDWYKEAMANKGKTIVTEPYESIS SGKMVVTIARQTVDGSGVVAIDMKIDDLVTTAKGINIGKEGYAFILSQNKKVIAYSGE KAGTELKGDWVDKLYKDKSGDFEYTYKGKKKKMAFATSQTTGWKISGTMYANEIHDAA SRVLIMASIVLAIAIGAGMTAIYFVIRSITKPLRRIVASAEKISEGDLTETIEINSKD ELGVLSESFNHMAHSLRSLIHGIKDSVEHVASSSEELTASADQTSRATEHITMAIEQF SNGSESQSEKIETTTEQINEMNDGLAELARAAAVITETSADSTEVSSKGETLVQKTAG QMNTIDHSVKAAEQVVKGLEIKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIESLISEIVKEIHTSLNVLQSVNKEVETGLVMTDE TKQSFKHISQMTNQIASELQNMNATVEELSAGAQEISAASNDITAISKESSDGIQDIA ASAEEQLASMEEISSSALTLERMSEELRDLTKQFKVDK*" /label="tlpA CDS" gene complement(2712361..2714349) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" /label="tlpA gene" promotor_-10 complement(2714374..2714392) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-10" upshifts complement(2714389) /Source="Nicolas_upshifts" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="upshifts" promotor_-35 complement(2714406..2714413) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-35" CDS complement(2714526..2716514) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391004.2" /db_xref="EnsemblGenomes-Gn:BSU31260" /db_xref="EnsemblGenomes-Tr:CAB15104" /db_xref="GOA:P39215" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10859" /db_xref="UniProtKB/Swiss-Prot:P39215" /translation="MKTFINWLKKPSISKKLIVSFIAILIIPILILEFSSYRSASGKL DQEIMGNAKNSVDTFNTTVTNDLGEKAKAVTFFSESLKRSAFKGKSNQEEIKAKFSQY VSINQGVARIYGGADNGTYVQAPKEKLPEGYDPRQRPWYQDAMKAGGEIVVTDPYVAA SDGSMVITIAQELKDGSGVVAMDITIDKLLEQMKQIKVGKEGYAFIATKNKTYVAHKN HKAGEKLSGDWVAKMYANDSGELQYTLNNEDKKMTYTTNELTGWKIAGTMYMDEIKDA SKSVLTTGMIVLIASIVAGGILILFIVRSITKPLKRLVQSSKTISRGDLTETIEIHSK DELGELGESFNEMGQSLRSLISAIQDSVNNVAASSEQLTASAGQTSKATEHITMAIEQ FSNGNEEQSEKVESSSHQLNLMNEGLQQVSQTSSDITKASIQSTEIAGTGEKFVQQTV GQMNSINQSVQQAEAVVKGLEGKSKDITSILRVINGIADQTNLLALNAAIEAARAGES GRGFSVVAEEVRKLAVQSADSAKEIEKLIQEIVAEIDTSLHMFKEVNQEVQSGLVVTD NTKESFQSIFSMTNEIAGKLQTMNSTVEQLSDRSQHVSAAVSGIADVSKESSASIQDI AASAEEQLASMEEISSSATTLAQMAEELRDLTKQFKIE*" /label="mcpB CDS" gene complement(2714526..2716514) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" /label="mcpB gene" downshifts complement(2714545) /Source="Nicolas_upshifts" /id="D1619" /incds=0 /nref=136 /ntot=224 /MaxReadThrough="3.76161" /MaxDrop="7.09773" /score="30.8363643" /energy="-10.7" /TU="U2427" /idTUdmin="U2427" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2716535..2716553) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2716556) /Source="Nicolas_upshifts" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2716566..2716573) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2716616..2716625 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2716639..2716658 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2716642 /Source="Nicolas_upshifts" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="upshifts" CDS 2716672..2717409 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" /EC_number="2.3.2.13" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9692191, 16267299, 16751597, 16936016, 18249137, 26322858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9692191, 16267299, 16751597, 16936016, 18249137, 26322858; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein-glutamine gamma-glutamyltransferase (transglutaminase)" /protein_id="NP_391005.1" /db_xref="EnsemblGenomes-Gn:BSU31270" /db_xref="EnsemblGenomes-Tr:CAB15105" /db_xref="GOA:P40746" /db_xref="InterPro:IPR020916" /db_xref="PDB:4P8I" /db_xref="PDB:4PA5" /db_xref="SubtiList:BG10946" /db_xref="UniProtKB/Swiss-Prot:P40746" /translation="MIIVSGQLLRPQDIENWQIDQDLNPLLKEMIETPVQFDYHSIAE LMFELKLRMNIVAAAKTLHKSGAKFATFLKTYGNTTYWRVSPEGALELKYRMPPSKAI RDIAENGPFYAFECATAIVIIYYLALIDTIGEDKFNASFDRIILYDWHYEKLPIYTET GHHFFLGDCLYFKNPEFDPQKAQWRGENVILLGEDKYFAHGLGILNGKQIIDKLNSFR KKGALQSAYLLSQATRLDVPSLFRIVR*" /label="tgl CDS" gene 2716672..2717409 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" /label="tgl gene" promotor_-10 complement(2716697..2716716) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-10" upshifts complement(2716705) /Source="Nicolas_upshifts" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="upshifts" promotor_-35 complement(2716732..2716736) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-35" S_feature 2717410..2720230 /Source="Nicolas_S_feature" /locus_tag="new_3213329_3216149" /HighExp="S6, S8, S7, BT, S5, C30, B36, Pyr, BC, C90" /AntisenseName="yugT" /AntisenseCor="0.63350809138227804" /AntisenseRegPval="-30.9" /CDS_PredictionProba="0.61985900000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1191" CDS complement(2717423..2717677) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097776.1" /db_xref="EnsemblGenomes-Gn:BSU31279" /db_xref="EnsemblGenomes-Tr:CAX52682" /db_xref="UniProtKB/Swiss-Prot:C0H3Q3" /translation="MNILQYSYKKRGKIEFVFEGWPHSKVTMVPIKGYYFVRFIKWSS QDPIVTRNDLEKMEWAANQYFGTAPFYRKRKAFETPSSGK*" /label="yuzH CDS" gene complement(2717423..2717677) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" /label="yuzH gene" downshifts complement(2717449) /Source="Nicolas_upshifts" /id="D1620" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="2.39206" /MaxDrop="2.92958" /score="-2.51333596" /energy="-14.7" /TU="NA" /idTUdmin="U2430" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2717678..2717934) /Source="Nicolas_S_feature" /locus_tag="new_3213597_3213853_c" /HighExp="Etha, Sw, Salt, Gly, BC, M9-stat, Lbstat, Heat, LPhT, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37980700000000001" /TUshortSig="SigB" /TUshortPSig="0.969" /TUlongSig="NA" /TUlongPSig="NA" /label="S1192" CDS complement(2717935..2718333) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391006.2" /db_xref="EnsemblGenomes-Gn:BSU31280" /db_xref="EnsemblGenomes-Tr:CAB15106" /db_xref="InterPro:IPR001602" /db_xref="InterPro:IPR035917" /db_xref="SubtiList:BG12373" /db_xref="UniProtKB/Swiss-Prot:O05243" /translation="MLKTLQIKTTKRDEMIDITREVEAFLQETGITSGAALIYCPHTT AGITINENADPDVKKDMLRRFDEVYPWEHELDRHMEGNTAAHMKSSTVGASQHVIVEN GRLILGTWQGIYFCEFDGPRTRTCYIKMMG*" /label="yugU CDS" gene complement(2717935..2718333) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" /label="yugU gene" CDS complement(2718293..2718427) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514000.1" /translation="MFYRVYESGLTGKKRTQNELSDESGQTKGETNAENTANQNNQTR *" /label="hypothetical protein CDS" gene complement(2718293..2718427) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" /label="gene" promotor_-10 complement(2718376..2718395) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2718383) /Source="Nicolas_upshifts" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2718410..2718416) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2718453..2720117) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1761534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-1,6-glucosidase" /protein_id="NP_391007.2" /db_xref="EnsemblGenomes-Gn:BSU31290" /db_xref="EnsemblGenomes-Tr:CAB15118" /db_xref="GOA:O05242" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG12372" /db_xref="UniProtKB/Swiss-Prot:O05242" /translation="MKKAWWKEAVVYQIYPRSFKDSNGDGIGDIQGIRTKLSYIKELG ADVIWICPLYDSPNADNGYDIRDYQNILSEFGTMEDFDELLGDIHDLDMKLIMDLVVN HTSDEHPWFIESRSSIHSEKRDWYIWKDGKNGKTPNNWESIFGGPAWEYDQKTSQYYL HLFDKKQPDLNWENEKVRNAVYDMINWWLDKGIDGFRVDAITHIKKKEGFPDMPNPKG LDYVPSFPYHMNADGIMDLLTELKENTFSRYPIMTVGEANGVAAKEAADWAGEKNGIF SMIFQFEHLGLWDVEINESIDIVAFKRILTDWQDSLEGIGWNALFMENHDQPRSVSVW GDDGVYLKESAKALSAVYFLMKGTPFIYQGQELGMTNVAFPSIEDYDDVALKRLYETK TAKGTSHEDVMKIVWKKGRDNSRTPMQWNAGPYAGFSEAKPWIGINENYKWLNAEAQK NDKTSVYHFYKSLIKLRQTYDVFINGTYELILPEDQQIFAYLRKNESHTALIAANLTG TPALFRHSGLPLSSDALVLSNIETEPHKHMTSVLLKPYEARIYLWC*" /label="yugT CDS" gene complement(2718453..2720117) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" /label="yugT gene" downshifts complement(2718469) /Source="Nicolas_upshifts" /id="D1621" /incds=0 /nref=13 /ntot=38 /MaxReadThrough="1.79723" /MaxDrop="4.64379" /score="19.4176812" /energy="-6.5" /TU="NA" /idTUdmin="U2432" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2719425..2719444) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2719430) /Source="Nicolas_upshifts" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2719458..2719465) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2720142..2720160) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2720159) /Source="Nicolas_upshifts" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2720176..2720181) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2720244..2721533) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_391008.2" /db_xref="EnsemblGenomes-Gn:BSU31300" /db_xref="EnsemblGenomes-Tr:CAB15119" /db_xref="GOA:O05241" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12371" /db_xref="UniProtKB/Swiss-Prot:O05241" /translation="MLILQLIAIFVLIGITAVFVAAEFAIVKIRGSKINQLIESGDSR ALAAHKIISNLDEYLSACQLGITITALGLGWLGEPTFERFLHPLFTMTGIPEPFNHIV TFVVAFIIVTFLHVVMGELAPKTVSIQKAEAVSLWIAKPLIWFYKITYPFIKALNGSA SFLVKLFGFHSVKEHQVVISEEELRLILSESYEKGEINQSEFRYVNKIFEFDNRVARE IMIPRTEIAVISLEQSLEEAIHHIINERYTRYPVIKDDKDHILGIINSKDMFKAYFLG QPIKLNQIMRPVIRVIESIPVQQLLIRMQKERIHMAILVDEYGGTAGLVTVEDIIEEI VGEIRDEYDQDETPHILKKGEHHYVMDGKALIDEVNDLLDIAIENEEIDTIAGWLLTQ KMELKAGDVIHAEGCEFKILDAEDHHIRFVEIKKTDF*" /label="yugS CDS" gene complement(2720244..2721533) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" /label="yugS gene" downshifts complement(2720253) /Source="Nicolas_upshifts" /id="D1622" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.89237" /MaxDrop="3.67001" /score="3.60520478" /energy="-7.6" /TU="NA" /idTUdmin="U2434" /TUdmin=13 /isTUend="TRUE" /label="downshifts" promotor_-35 2721062..2721068 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2721082..2721100 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2721088 /Source="Nicolas_upshifts" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="upshifts" S_feature 2721092..2721744 /Source="Nicolas_S_feature" /locus_tag="new_3217011_3217663" /HighExp="Etha, Sw, Gly, Salt, BC, B60, Heat, S8, B36, HiTm" /AntisenseName="yugS" /AntisenseCor="0.12310225183111501" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1193" CDS complement(2721577..2722254) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16704729, 16850406, 24383880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent protease/peptidase" /protein_id="NP_391009.1" /db_xref="EnsemblGenomes-Gn:BSU31310" /db_xref="EnsemblGenomes-Tr:CAB15120" /db_xref="GOA:O05248" /db_xref="InterPro:IPR007395" /db_xref="SubtiList:BG12370" /db_xref="UniProtKB/Swiss-Prot:O05248" /translation="MLFIFLTIAALGLSFWAQFKVKSNFEKYSKVEASSGRTGAETAR RILDINGLYDVPVEPVRGTLTDHYDPTRRVVRLSEPVYYGRSISAISVASHEVGHALQ HQESYGALVLRHKIFPVVNFASGVAPLLFLGGMLLGSLNLIGLGIILFSAAVFFQLIT LPVEFNASSRAKQIIVSEGFIRNNEENGVNKVLSAAALTYVAAALVSLFELLRFVMIF LNGRDEN*" /label="yugP CDS" gene complement(2721577..2722254) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" /label="yugP gene" downshifts complement(2721587) /Source="Nicolas_upshifts" /id="D1623" /incds=0 /nref=153 /ntot=249 /MaxReadThrough="3.51629" /MaxDrop="4.854" /score="33.0420688" /energy="-13" /TU="U2434,U2435" /idTUdmin="U2435" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" S_feature 2721929..2722605 /Source="Nicolas_S_feature" /locus_tag="new_3217848_3218524" /HighExp="Sw, S8, Salt, BC, S7, Etha, Gly, B36, B60, LPhT" /AntisenseName="yuzI" /AntisenseCor="0.20035821815170399" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1194" promotor_-10 complement(2722289..2722308) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2722296..2722559) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16704729; Product type f : factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097777.1" /db_xref="EnsemblGenomes-Gn:BSU31319" /db_xref="EnsemblGenomes-Tr:CAX52683" /db_xref="GOA:C0H3Q4" /db_xref="UniProtKB/Swiss-Prot:C0H3Q4" /translation="MTIFQRTIVVLIGTQLAASAVILFIFDLNSYNHFSGSFSWLHFL KELAGSFAFYLFSAGLFFLLIGLCAPSRKKKRISVHEKENSLK*" /label="yuzI CDS" gene complement(2722296..2722559) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" /label="yuzI gene" upshifts complement(2722310) /Source="Nicolas_upshifts" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2722322..2722329) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2722571..2722589) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2722585) /Source="Nicolas_upshifts" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2722605..2722610) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2722606..2722938 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15731457, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15731457, 23737939, 25297828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="atypical membrane-integrating regulator of biofilm formation (Mistic protein)" /protein_id="YP_003097778.1" /db_xref="EnsemblGenomes-Gn:BSU31321" /db_xref="EnsemblGenomes-Tr:CAX52684" /db_xref="GOA:Q5BU39" /db_xref="InterPro:IPR021078" /db_xref="PDB:1YGM" /db_xref="UniProtKB/Swiss-Prot:Q5BU39" /translation="MFCTFFEKHHRKWDILLEKSTGVMEAMKVTSEEKEQLSTAIDRM NEGLDAFIQLYNESEIDEPLIQLDDDTAELMKQARDMYGQEKLNEKLNTIIKQILSIS VSEEGEKE*" /label="mstX CDS" gene 2722606..2722938 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" /label="mstX gene" promotor_-35 2722623..2722629 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2722644..2722661 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2722655 /Source="Nicolas_upshifts" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="upshifts" CDS 2722935..2723921 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16704729, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16704729, 23737939, 25297828; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium channel protein involved in biofilm formation" /protein_id="NP_391010.3" /db_xref="EnsemblGenomes-Gn:BSU31322" /db_xref="EnsemblGenomes-Tr:CAB15121" /db_xref="GOA:Q795M8" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR013099" /db_xref="InterPro:IPR028325" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12369" /db_xref="UniProtKB/Swiss-Prot:Q795M8" /translation="MKSNRIFISWLRWPLFIRIGVIILCLILLFGQIIYILEPKQFTS VFEGIWWAVVTVSTVGYGDYVPHTPLGQAAGILLILSGASFVTAYFATLSAAAFSRQH RYIEGKVAYKGRDHIILIGWNEKTNRLLKDLQLAAPSKTVVLIDESLTEGPLIENVHF IRGHAADDGTLKRANITEAESVMITADQYKSETDADMLSVLTLLSVKGLNPLAYCIVE ILTDRFVTNAERAGANQIIGTSEFISRAMLQHYQVKLRPSKQQNGIKLTLDQHVELLA VPDELKGAAYKTCVLYFLDHNTTIIGIQKKEGPMLSPPLTYKVLETDQFLAI*" /label="kbfO CDS" gene 2722935..2723921 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" /label="kbfO gene" downshifts complement(2723896) /Source="Nicolas_upshifts" /id="D1624" /incds=0 /nref=44 /ntot=128 /MaxReadThrough="0.617940000000001" /MaxDrop="4.76695" /score="21.5904825" /energy="-11.3" /TU="NA" /idTUdmin="U2437" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2723918..2724322) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391011.1" /db_xref="EnsemblGenomes-Gn:BSU31330" /db_xref="EnsemblGenomes-Tr:CAB15122" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG12368" /db_xref="UniProtKB/Swiss-Prot:O05246" /translation="MIPIPSAIDGQSFLLQELEQVMKPLGYVINGGWEYDHGYFDYKI DDRDGYLFLRIPVNAVQGSLDERGAAVRIGTPFMLRQVFQADVDDHAEGGPFQSLFNQ FSEPERRDAEIDPAFLDIGASLVKELEDVLLH*" /label="yugN CDS" gene complement(2723918..2724322) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" /label="yugN gene" S_feature complement(2724323..2724381) /Source="Nicolas_S_feature" /locus_tag="new_3220242_3220300_c" /HighExp="M0t90, M40t90, S6, S8, S7, T0.30H, Lbstat, M9-stat, T1.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-, SigA" /TUshortPSig="0.686, 0.141, 0.984" /TUlongSig="SigA" /TUlongPSig="0.988" /label="S1195" CDS complement(2724382..2724753) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391012.1" /db_xref="EnsemblGenomes-Gn:BSU31340" /db_xref="EnsemblGenomes-Tr:CAB15123" /db_xref="GOA:O05245" /db_xref="SubtiList:BG12367" /db_xref="UniProtKB/Swiss-Prot:O05245" /translation="MFMKQLVKHLIIAGFSAAILSFLISFDAVYTGFSSSFGGTLSHF FIHSFLLIGLPLALFTDAVHRILHLKRTHTLFTKLGLYATVVYVSWDSAVWLAAAMAV YFLIECAFFPVGRAKETTISM*" /label="yugM CDS" gene complement(2724382..2724753) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" /label="yugM gene" CDS complement(2724812..2726164) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /EC_number="5.3.1.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4214896, 4275311, 11489127, 19052382, 21453533, 22720735, 24705866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate isomerase" /protein_id="NP_391013.2" /db_xref="EnsemblGenomes-Gn:BSU31350" /db_xref="EnsemblGenomes-Tr:CAB15124" /db_xref="GOA:P80860" /db_xref="InterPro:IPR001672" /db_xref="InterPro:IPR018189" /db_xref="InterPro:IPR035476" /db_xref="InterPro:IPR035482" /db_xref="SubtiList:BG12366" /db_xref="UniProtKB/Swiss-Prot:P80860" /translation="MTHVRFDYSKALTFFNEHELTYLRDFVKTAHHNIHEKTGAGSDF LGWVDLPEHYDKEEFARIKKSAEKIKSDSDVLLVVGIGGSYLGARAAIEALNHAFYNT LPKAKRGNPQVIFIGNNISSSYMRDVMDLLEDVDFSINVISKSGTTTEPAIAFRIFRK LLEEKYGKEEAKARIYATTDKERGALKTLSNEEGFESFVIPDDVGGRYSVLTAVGLLP IAVSGVNIDDMMKGALDASKDFATSELEDNPAYQYAVVRNVLYNKGKTIEMLINYEPA LQYFAEWWKQLFGESEGKDEKGIYPSSANYSTDLHSLGQYVQEGRRDLFETVLNVEKP KHELTIEEADNDLDGLNYLAGKTVDFVNKKAFQGTMLAHTDGNVPNLIVNIPELNAYT FGYLVYFFEKACAMSGYLLGVNPFDQPGVEAYKVNMFALLGKPGFEEKKAELEKRLED *" /label="pgi CDS" gene complement(2724812..2726164) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /label="pgi gene" downshifts complement(2724823) /Source="Nicolas_upshifts" /id="D1625" /incds=0 /nref=90 /ntot=198 /MaxReadThrough="6.86736" /MaxDrop="4.4585" /score="24.139293" /energy="-16.8" /TU="U2437,U2438,U2439" /idTUdmin="U2441" /TUdmin=19 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2724979..2724997) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2724996) /Source="Nicolas_upshifts" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2725013..2725018) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2726137) /Source="Nicolas_upshifts" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2726140..2726151) /Source="Nicolas_upshift_promotors" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2726196..2726215) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2726202) /Source="Nicolas_upshifts" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2726204..2726275) /Source="Nicolas_S_feature" /locus_tag="new_3222123_3222194_c" /HighExp="Etha, H2O2, Paraq, Oxctl, G180, G150, dia5, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.988" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1196" promotor_-35 complement(2726230..2726233) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2726276..2727448) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 1809209, 2673038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase subunit" /protein_id="NP_391014.1" /db_xref="EnsemblGenomes-Gn:BSU31360" /db_xref="EnsemblGenomes-Tr:CAB15125" /db_xref="GOA:O05240" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12365" /db_xref="UniProtKB/Swiss-Prot:O05240" /translation="MENFTYYNPTKLIFGKGQLEQLRKEFKRYGKNVLLVYGGGSIKR NGLYDQVTGILKEEGAVVHELSGVEPNPRLATVEKGIGLCREHDIDFLLAVGGGSVID CTKAIAAGVKYDGDAWDIFSKKVTAEDALPFGTVLTLAATGSEMNPDSVITNWETNEK FVWGSNVTHPRFSILDPENTFTVPENQTVYGMVDMMSHVFEQYFHNVENTPLQDRMCF AVLQTVIETAPKLLEDLENYELRETILYAGTIALNGTLQMGYFGDWASHTMEHAVSAV YDIPHAGGLAILFPNWMRYTLDTNVGRFKNLMLNMFDIDTEGKTDKEIALEGIDKLSA FWTSLGAPSRLADYNIGEEKLELIADIAAKEMEHGGFGNFQKLNKDDVLAILRASL*" /label="bdhK CDS" gene complement(2726276..2727448) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /label="bdhK gene" S_feature 2726611..2727532 /Source="Nicolas_S_feature" /locus_tag="new_3222530_3223451" /HighExp="S6, S7, S8, BT, S5, C30, LBGstat, B36, G135, G150" /AntisenseName="yugK" /AntisenseCor="4.31382473780575E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1197" promotor_-10 complement(2727481..2727500) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-10" upshifts complement(2727494) /Source="Nicolas_upshifts" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="upshifts" promotor_-35 complement(2727517..2727520) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-35" CDS complement(2727552..2728715) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 2673038, 9643546, 11466286, 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase" /protein_id="NP_391015.1" /db_xref="EnsemblGenomes-Gn:BSU31370" /db_xref="EnsemblGenomes-Tr:CAB15126" /db_xref="GOA:O05239" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12364" /db_xref="UniProtKB/Swiss-Prot:O05239" /translation="MQNFTYWNPTKLIFGRGEVERLPEELKPYGKNVLLVYGGGSIKR SGLYDQVIEQLNKAGATVHELAGVEPNPRVSTVNKGVAICKEQNIDFLLAVGGGSVID CTKAIAAGAKYDGDAWDIVTKKHQPKDALPFGTVLTLAATGSEMNSGSVITNWETKEK YGWGSPLVFPKFSILDPVNTFTVPKNHTIYGMVDMMSHVFEQYFHHVSNTPYQDRMCE SLLRTVIETAPKLINDLENYELRETILYTGTIALNGMLSMGARGDWATHNIEHAVSAV YDIPHAGGLAILFPNWMRHTLSENPARMKQLAVRVFDVEEAGKTDEEIALEGIDKLSA FWTSLGAPNRLADYDINDEQLDTIADKAMANGTFGQFKSLNKEDVLSILKASL*" /label="bdhJ CDS" gene complement(2727552..2728715) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /label="bdhJ gene" downshifts complement(2727567) /Source="Nicolas_upshifts" /id="D1626" /incds=0 /nref=167 /ntot=237 /MaxReadThrough="6.69366" /MaxDrop="4.74696" /score="28.8200012" /energy="-13.4" /TU="U2441" /idTUdmin="U2444" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2728730..2728749) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-10" upshifts complement(2728748) /Source="Nicolas_upshifts" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="upshifts" S_feature complement(2728750..2728905) /Source="Nicolas_S_feature" /locus_tag="new_3224669_3224824_c" /HighExp="S8, S7, S4, S5, S6, LoTm, Cold, LBGtran, G180, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25658199999999998" /TUshortSig="SigGF, SigA" /TUshortPSig="0.679, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1198" promotor_-35 complement(2728764..2728771) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-35" promotor_-35 2728801..2728807 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2728822..2728840 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2728832 /Source="Nicolas_upshifts" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2728833..2728891 /Source="Nicolas_S_feature" /locus_tag="new_3224752_3224810" /HighExp="Etha, Salt, Heat, M9-stat, LPhT, Sw, Gly, BC, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1199" promotor_-35 2728878..2728884 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2728880..2728891) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2728893 /Source="Nicolas_upshifts" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2728898..2728909 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2728905..2728911) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2728905) /Source="Nicolas_upshifts" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2728907..2729218) /Source="Nicolas_S_feature" /locus_tag="new_3224826_3225137_c" /HighExp="Cold, LBGtran, LoTm, G180, LBGexp, dia15, G135, H2O2, Paraq, Oxctl" /AntisenseName="yuzA" /AntisenseCor="-0.50065532030853999" /AntisenseRegPval="-17.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1200" CDS 2728945..2729181 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391016.1" /db_xref="EnsemblGenomes-Gn:BSU31380" /db_xref="EnsemblGenomes-Tr:CAB15127" /db_xref="GOA:O32087" /db_xref="InterPro:IPR007211" /db_xref="SubtiList:BG14050" /db_xref="UniProtKB/Swiss-Prot:O32087" /translation="MSTIQRICLVLTIIGAINWGLIGFFQFDLVAAIFGGQGSALSRI IYGLVGIAGLINLGLLFKPNEERSREEAANPEMR*" /label="yuzA CDS" gene 2728945..2729181 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /label="yuzA gene" downshifts 2729141 /Source="Nicolas_upshifts" /id="D1627" /incds=0 /nref=3 /ntot=45 /MaxReadThrough="7.39676" /MaxDrop="2.87922" /score="13.9936296" /energy="-12" /TU="U2442,U2443" /idTUdmin="U2442" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 2729207 /Source="Nicolas_upshifts" /id="D1628" /incds=0 /nref=25 /ntot=56 /MaxReadThrough="1.29261" /MaxDrop="7.50276" /score="13.9936296" /energy="-12" /TU="NA" /idTUdmin="U2442" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2729259..2729651) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 16014871, 19152054, 19636895; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; putative phosphorylase or nucleotidyl transferase; general stress protein" /protein_id="NP_391017.1" /db_xref="EnsemblGenomes-Gn:BSU31390" /db_xref="EnsemblGenomes-Tr:CAB15128" /db_xref="GOA:P80870" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="PDB:2K4K" /db_xref="SubtiList:BG12363" /db_xref="UniProtKB/Swiss-Prot:P80870" /translation="MAAKFEVGSVYTGKVTGLQAYGAFVALDEETQGLVHISEVTHGF VKDINEHLSVGDEVQVKVLAVDEEKGKISLSIRATQAAPEKKESKPRKPKAAQVSEEA STPQGFNTLKDKLEEWIEMSNRKDLIKK*" /label="yugI CDS" gene complement(2729259..2729651) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /label="yugI gene" downshifts complement(2729263) /Source="Nicolas_upshifts" /id="D1629" /incds=0 /nref=232 /ntot=268 /MaxReadThrough="5.9665" /MaxDrop="6.0195" /score="13.5952751" /energy="-15.6" /TU="U2445" /idTUdmin="U2448" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2729693..2729712) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-10" upshifts complement(2729700) /Source="Nicolas_upshifts" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="upshifts" S_feature complement(2729702..2729852) /Source="Nicolas_S_feature" /locus_tag="new_3225621_3225771_c" /HighExp="G180, C30, G135, LBGexp, G150, Oxctl, HPh, Cold, BMM, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1201" promotor_-35 complement(2729728..2729732) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-35" promotor_-35 2729755..2729761 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2729768..2730752 /Source="Nicolas_S_feature" /locus_tag="new_3225687_3226671" /HighExp="LoTm, C30, Salt, S7, S5, S8, Sw, S3, C90, S6" /AntisenseName="yugH" /AntisenseCor="-0.45629591209076698" /AntisenseRegPval="-14.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.662" /TUlongSig="NA" /TUlongPSig="NA" /label="S1202" upshifts 2729768 /Source="Nicolas_upshifts" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2729776..2729794 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2729853..2731013) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /EC_number="2.6.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_391018.2" /db_xref="EnsemblGenomes-Gn:BSU31400" /db_xref="EnsemblGenomes-Tr:CAB15129" /db_xref="GOA:Q795M6" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12362" /db_xref="UniProtKB/Swiss-Prot:Q795M6" /translation="MTSYLSDYVQQIKPSGIRKFFDLAATMEGVISLGVGEPDFVTAW NVREASILSLEQGYTSYTANAGLYSLREEISRYLSNRFDLSYSPDNELIVTVGASQAL DIAIRAIVNPGEEVIIPEPCFVAYDALVSLAGGIPVHVHTTADKGFKATAADFEAAVT EKTKAILICSPSNPTGSVYSKEELNEIAEFAKKHDVIVLADEIYAELTYDEEFTSIAA LPGMKERTVVISGFSKAFAMTGWRLGFAAAPSLLRDAMLKIHQYAMMCAPAMAQFAAL EGLKNGMEDVEKMKKSYRRRRNLFVESLNEIGLSCHHPGGAFYAFPSIKSMGMSSEQF AEELLTQEKVAVVPGSVFGPSGEGYIRCSYATSIEQLQEALVRMKRFLHKTT*" /label="yugH CDS" gene complement(2729853..2731013) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /label="yugH gene" promotor_-35 2730905..2730911 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2730923 /Source="Nicolas_upshifts" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2730925..2730929 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2731014..2731514) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_391019.1" /db_xref="EnsemblGenomes-Gn:BSU31410" /db_xref="EnsemblGenomes-Tr:CAB15130" /db_xref="GOA:O05236" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12361" /db_xref="UniProtKB/Swiss-Prot:O05236" /translation="MKLTEKETEILEILDENSRADLETIAKMAGIPVNEVKTIIDKLE KEKVIIDYSAMIDWRKVDGHEGVTAMIDVKVTPKRGVGFDEVAERIYRFQEVESVYLM SGVYDLSVVIRGNSMSDVARFVSDKLSTLDSVVSTTTHFILKKYKHDGKVFETGDDDK RIVVSP*" /label="yugG CDS" gene complement(2731014..2731514) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /label="yugG gene" promotor_-10 complement(2731544..2731563) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-10" promotor_-35 2731550..2731556 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2731565) /Source="Nicolas_upshifts" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="upshifts" promotor_-10 2731571..2731582 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2731571 /Source="Nicolas_upshifts" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2731574..2731581) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-35" S_feature 2731583..2731661 /Source="Nicolas_S_feature" /locus_tag="new_3227502_3227580" /HighExp="S8, S5, S6, S7, S4, C30, Glucon, Pyr, nit, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1203" CDS 2731662..2732483 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391020.1" /db_xref="EnsemblGenomes-Gn:BSU31420" /db_xref="EnsemblGenomes-Tr:CAB15131" /db_xref="GOA:O05235" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR013595" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12360" /db_xref="UniProtKB/Swiss-Prot:O05235" /translation="MEAVSPIRRFTVDGVNVYYEHYQNPGRQTLVCVHGFLSSAFSFR KVIPLLRDKYDIIALDLPPFGQSEKSRTFIYTYQNLAKLVIGILEHLQVKQAVLVGHS MGGQISLSAALQKPELFSKVVLLCSSGYLKRSHPTIIFGTHIPYFHLYIKRWLSKEGV MKNLLNVVHDKSLIDEEMIDGYGRPFQDEQIFKAMTRFIRHREGDLEPEQLKKMNKPA LLIWGEEDRIVPMEIGKRLHADLPNSVLYSLGQTGHLVPEERPELISEHIADFIK*" /label="yugF CDS" gene 2731662..2732483 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /label="yugF gene" downshifts 2732463 /Source="Nicolas_upshifts" /id="D1630" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="1.0929" /MaxDrop="3.08755" /score="11.2614618" /energy="-6.6" /TU="NA" /idTUdmin="U2449" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2732510) /Source="Nicolas_upshifts" /id="D1631" /incds=0 /nref=20 /ntot=156 /MaxReadThrough="2.22671" /MaxDrop="4.10906" /score="25.9859375" /energy="-6.6" /TU="NA" /idTUdmin="U2451" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(2732512..2732772) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391021.2" /db_xref="EnsemblGenomes-Gn:BSU31430" /db_xref="EnsemblGenomes-Tr:CAB15132" /db_xref="InterPro:IPR015053" /db_xref="InterPro:IPR023162" /db_xref="SubtiList:BG12359" /db_xref="UniProtKB/Swiss-Prot:O05234" /translation="MEESHAVREMIKIIAKWDPFKYGEEFYETEAVDVVQAVYDENDP DLLAKSIQQIFETSFEQTLPIASCREVAGQLLFIKNSSSCTP*" /label="yugE CDS" gene complement(2732512..2732772) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /label="yugE gene" promotor_-35 2732762..2732765 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-35" promotor_-10 2732780..2732799 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-10" upshifts 2732792 /Source="Nicolas_upshifts" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="upshifts" S_feature 2732793..2732858 /Source="Nicolas_S_feature" /locus_tag="new_3228712_3228777" /HighExp="dia15, dia5, Lbexp, dia0, LBGtran, G180, Diami, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1204" promotor_-10 complement(2732798..2732817) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2732803) /Source="Nicolas_upshifts" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2732829..2732835) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2732859..2734022 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /EC_number="4.4.1.1" /EC_number="4.4.1.13" /EC_number="4.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15760717, 26337367, 28895253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15760717, 26337367, 28895253; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous cystathionine / cystine beta-lyase /cysteine desulfhydrase" /protein_id="NP_391022.1" /db_xref="EnsemblGenomes-Gn:BSU31440" /db_xref="EnsemblGenomes-Tr:CAB15133" /db_xref="GOA:Q08432" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR027619" /db_xref="SubtiList:BG10744" /db_xref="UniProtKB/Swiss-Prot:Q08432" /translation="MNFDKREERLGTQSVKWDKTGELFGVTDALPMWVADMDFRAPEA ITEALKERLDHGIFGYTTPDQKTKDAVCGWMQNRHGWKVNPESITFSPGVVTALSMAV QAFTEPGDQVVVQPPVYTPFYHMVEKNGRHILHNPLLEKDGAYAIDFEDLETKLSDPS VTLFILCNPHNPSGRSWSREDLLKLGELCLEHGVTVVSDEIHSDLMLYGHKHTPFASL SDDFADISVTCAAPSKTFNIAGLQASAIIIPDRLKRAKFSASLQRNGLGGLNAFAVTA IEAAYSKGGPWLDELITYIEKNMNEAEAFLSTELPKVKMMKPDASYLIWLDFSAYGLS DAELQQRMLKKGKVILEPGTKYGPGGEGFMRLNAGCSLATLQDGLRRIKAALS*" /label="patB CDS" gene 2732859..2734022 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /label="patB gene" promotor_-35 2734085..2734091 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2734103..2734122 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2734113 /Source="Nicolas_upshifts" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="upshifts" CDS 2734148..2735434 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9426145, 11069677, 15849754, 16850406, 26152584, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 11069677, 15849754, 16850406, 26152584, 28583948; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-binding histidinekinase" /protein_id="NP_391023.2" /db_xref="EnsemblGenomes-Gn:BSU31450" /db_xref="EnsemblGenomes-Tr:CAB15134" /db_xref="GOA:Q08430" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10745" /db_xref="UniProtKB/Swiss-Prot:Q08430" /translation="MEILKDYLLHICFILFPILLYQVFWLGKPAILVPKINSGLVTLF ACGASVLCIIFPIHEMDYIQYGLQMIPVIICLFYISTASGLTVAASVLCFELLFYEPS AMFVFTLLPFLIIIPILFQKKWPFMSKAKKLLLSLLISCVEIFLFFASSWILSALNIL NFQKSGIFVYEAAVSGLFRSSVLLLSIYIIESIAENIALRSQLIHSEKMTIVSELAAS VAHEVRNPLTVVRGFVQLLFNDETLQNKSSADYKKLVLSELDRAQGIITNYLDMAKQQ LYEKEVFDLSALIKETSSLMVSYANYKSVTVEAETEPDLLIYGDATKLKQAVINLMKN SIEAVPHGKGMIHISAKRNGHTIMINITDNGVGMTDHQMQKLGEPYYSLKTNGTGLGL TVTFSIIEHHHGTISFNSSFQKGTTVTIKLPADLPH*" /label="kinB CDS" gene 2734148..2735434 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /label="kinB gene" S_feature complement(2735150..2735892) /Source="Nicolas_S_feature" /locus_tag="new_3231069_3231811_c" /HighExp="BT, S8, B36, S6, S7, S5, S3, S4, Cold, Pyr" /AntisenseName="kapB" /AntisenseCor="-0.71681066342113797" /AntisenseRegPval="-43" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigK" /TUshortPSig="0.709, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1205" promotor_-35 2735429..2735436 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2735450..2735469 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2735451 /Source="Nicolas_upshifts" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="upshifts" CDS 2735480..2735866 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9426145, 23335417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 23335417; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for KinB signal transduction andactivation of the phosphorelay to sporulation" /protein_id="NP_391024.1" /db_xref="EnsemblGenomes-Gn:BSU31460" /db_xref="EnsemblGenomes-Tr:CAB15135" /db_xref="GOA:Q08429" /db_xref="InterPro:IPR014916" /db_xref="SubtiList:BG10746" /db_xref="UniProtKB/Swiss-Prot:Q08429" /translation="MSTFETGSIVKGFYKTGVYIGEITACRPQHYLVKVKAVLTHPAQ GDLHHPKQADVPFFHERKALAYGEQTNIPHHMVKPYDGEVPDYTESLREATAQMRAKL NEDGSEWAKRSLHNLDILEKEYFNRP*" /label="kapB CDS" gene 2735480..2735866 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /label="kapB gene" downshifts 2735848 /Source="Nicolas_upshifts" /id="D1632" /incds=0 /nref=209 /ntot=249 /MaxReadThrough="1.62013" /MaxDrop="5.57132" /score="1.97959632" /energy="-9.2" /TU="NA" /idTUdmin="U2452" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2735893..2736510) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /EC_number="3.1.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27188294; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exoribonuclease (3'-5')" /protein_id="NP_391025.1" /db_xref="EnsemblGenomes-Gn:BSU31470" /db_xref="EnsemblGenomes-Tr:CAB15136" /db_xref="GOA:O05231" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12358" /db_xref="UniProtKB/Swiss-Prot:O05231" /translation="MTTNSLLIIDFEFTMPDGKYSPQNFFPEIIEAGIVKSIDDEVVE TFSSYVRPKKFPKLTKRCKSFLKITQKQVDEGMRFEDFIRKLNELDPEKNSTIITWGN MDMKVLKQNCMFNHIPFPFKGEMRDLSLEYKNFFGDRTLTGLWKAAEEYGDSGTGTHH KALDDALTAYKLFKLVEQDKQYLEKPKPPTIGERIDLTELLKRAT*" /label="kapD CDS" gene complement(2735893..2736510) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /label="kapD gene" promotor_-10 complement(2736545..2736563) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2736562) /Source="Nicolas_upshifts" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2736564..2738652) /Source="Nicolas_S_feature" /locus_tag="new_3232483_3234571_c" /HighExp="S8, BT, B36, S7, S6, Pyr, C30, B60, S5, G135" /AntisenseName="yuxJ" /AntisenseCor="-0.168930816447634" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1206" promotor_-35 complement(2736578..2736583) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2736626..2736629 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-35" promotor_-10 2736644..2736663 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-10" upshifts 2736655 /Source="Nicolas_upshifts" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="upshifts" CDS 2736721..2737899 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter induced in acid stress" /protein_id="NP_391026.2" /db_xref="EnsemblGenomes-Gn:BSU31480" /db_xref="EnsemblGenomes-Tr:CAB15137" /db_xref="GOA:P40760" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10976" /db_xref="UniProtKB/Swiss-Prot:P40760" /translation="MWLANFFVSASTTMIVPFLSLYIETLSSFSNGFVQRWSGYVFGI TFLMAFLVSPFWGRFGDKRGYKKILMATGTGIALSIFFMGFVTSVYQLFFLRMAMGLV TGFIPTSLAMISAQTPKSSAGKTLGTLQMGQVSGSLFGPLLGGMLADRFGFTYTFFIT SFVIFSSVLLVLFGVKEKHLAEKTAKRTSYSRKEVLSYIFHHPALWVMMLLTMLIQTG NFSIQPLLALYVNELHGPVNLAFFSGMAFSATGLGSLLLARKWGDLGDRYGHRRILIG LLLAASFFFIPQALASSLSVLLVFRFLFGMAMGGLLPCITAAIRVQAPGSIQGEVLGY NVSFRFLGNVLGPLLGGIISSHFTISATFYVTAFLFFAGACMLWIMQKLRKDSYAKAS *" /label="yuxJ CDS" gene 2736721..2737899 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /label="yuxJ gene" promotor_-35 2737937..2737943 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2737955..2737974 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2737960 /Source="Nicolas_upshifts" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="upshifts" CDS 2737992..2739866 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /EC_number="2.-.-.-" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7961491, 9274030; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4" /protein_id="NP_391027.2" /db_xref="EnsemblGenomes-Gn:BSU31490" /db_xref="EnsemblGenomes-Tr:CAB15138" /db_xref="GOA:P40750" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10977" /db_xref="UniProtKB/Swiss-Prot:P40750" /translation="MTMLRKIIGWILLLCIIPLFAFTVIASGKEVKQMKSLDQVLDKN IDLKDISLVQNSYMYDRDGSLVSEIVSDHENRVLVPFNKIPEEVKQIFLTSEDRHFYE HKGFDFMGMVRATASNVKDKKIDQGASTITQQLSRNLYLSHERSFSRKLTELAYSYQL EKKYTKNEILEAYLNTIYFNNGVYGVGSAAQFYFSKPLKSLTVGEMAFICAIPNNPTL YDPLKHFDYTKSRQERLLKGLKDAGVITDKELKKAVKQKIKLDVEKREDKYPDYVSYV NDEFTQLVSESEGFDKRLQKASGKQKEKIENELSARVSTLMKDGVKIYTALDPYMQNQ VVAQMNSKLPYADVQGGAAVINHQTHQIIALSGGKNYQKYDFNRAYQAYRQPGSSIKP LLDYGPYIEQTGATTSSTIDASKFCSKDYCPQNYNNRTYGTVTLDTAFKNSYNTPAIR MLDRVGIQKAFSYIEPYHFAKLVDSDYLLPAALGGFTNGMTPLEMTKAYTTFGNSGSY TPSHAITKVTDLKGKTLYKWNDKATQIFSVRTNMQLKKLMSSVVKSGTGKKAYFNAPY IGGKTGTSNDYHDMWFVGLTDTYTMGVWVGKDTPTSVEYLHSISPQLSIWKGTLQAAY *" /label="pbpD CDS" gene 2737992..2739866 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /label="pbpD gene" promotor_-10 complement(2738632..2738651) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2738652) /Source="Nicolas_upshifts" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2738665..2738674) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2739887..2740300 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26335199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase" /protein_id="NP_391028.1" /db_xref="EnsemblGenomes-Gn:BSU31500" /db_xref="EnsemblGenomes-Tr:CAB15139" /db_xref="InterPro:IPR007263" /db_xref="SubtiList:BG10978" /db_xref="UniProtKB/Swiss-Prot:P40761" /translation="MTSEQIPNRVLLFDGVCNLCNGAVQFIIKRDPDGLISFTSLQSE TGQSLLKKSGLPTDRFDSFVFIEDGQVYTKSTAAIKVFRHLRGPWRLFVLFFAVPKPV RDMVYSFIAKNRYKWFGKKNECMLPSPSIKKRFLP*" /label="yuxK CDS" gene 2739887..2740300 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /label="yuxK gene" downshifts 2740292 /Source="Nicolas_upshifts" /id="D1633" /incds=0 /nref=1 /ntot=254 /MaxReadThrough="5.05064" /MaxDrop="3.14634" /score="-3.58105315" /energy="-11.5" /TU="U2456" /idTUdmin="U2456" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2740503..2741060) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391029.2" /db_xref="EnsemblGenomes-Gn:BSU31510" /db_xref="EnsemblGenomes-Tr:CAB15140" /db_xref="GOA:O05249" /db_xref="InterPro:IPR035289" /db_xref="SubtiList:BG12346" /db_xref="UniProtKB/Swiss-Prot:O05249" /translation="MKNTYLTGYFPLIAILLFSSSLSISTSLYALKMLSSFGMYDGML DYFSEKGIRLALFAAFALLYFMVLSALKLIANTVTELSLLFFANDPEGNNLKKLRMGS MIYLGGGILSFVLLQNVIWIVIWFAVVTLAYFVFTVYRIYSTLSLMSLVGFILLELLF WFTFVIGILFIFIKLYNSIMASLPV*" /label="yufK CDS" gene complement(2740503..2741060) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /label="yufK gene" misc_feature 2740524..2740543 /Source="Nicolas_upshift_promotors" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2740534 /Source="Nicolas_upshifts" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2740544) /Source="Nicolas_upshifts" /id="D1634" /incds=0 /nref=10 /ntot=201 /MaxReadThrough="3.90201" /MaxDrop="3.94501" /score="-6.00543052" /energy="-18.5" /TU="U2459" /idTUdmin="U2459" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 2740556..2741237 /Source="Nicolas_S_feature" /locus_tag="new_3236475_3237156" /HighExp="Diami, Cold, LBGstat, H2O2, Lbtran, Gly, M0t90, GM 10, GM-0.2, dia15" /AntisenseName="yufK" /AntisenseCor="0.32488342936044701" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.878" /TUlongSig="NA" /TUlongPSig="NA" /label="S1207" promotor_-10 complement(2741086..2741105) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2741094) /Source="Nicolas_upshifts" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2741121..2741125) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2741238..2742839 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [MaeM]" /protein_id="NP_391030.1" /db_xref="EnsemblGenomes-Gn:BSU31520" /db_xref="EnsemblGenomes-Tr:CAB15141" /db_xref="GOA:O05250" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12347" /db_xref="UniProtKB/Swiss-Prot:O05250" /translation="MKKTLKLQTRLTIFVCIVVLIALLITFFTVGAQTTKRIRDQEKA TALQTAEMVAEAPMTAAALESGKKQKELQSYTKRVQKITGTEFVVVMDMNGIRKTHPD PSKIGKKFRGGDESEVLKGHVHISTASGTLGKSQRAFVPVYAENGKQVGAVAVGITVN EIDEVISHSLRPLYFIICVSIFVGVIGAVIVARTVKNIMYGLEPYEIATLLEERSAML ESTKEGILAVDEHGKIKLANAEAKRLFVKMGINTNPIDQDVDDILPKSRLKKVIETKK PLQDRDVRINGLELVFNEVPIQLKGQTVGAIATFRDKTEVKHLAEQLSGVKMYANALR AQSHEFMNKLHVILGLVQLKEYDDLGDYIKDIAIQQKSETSEIINDVKSSVLAGFLLG KQSFIREQGANLDIECNGVIPNAADPSVIHELITIIGNLINNGLDAVADMPKKQITMS MRFHNSILDIEITDTGAGMSEEDQAKVFEQGYSTKGKNRGFGLYFTQQSIENLKGQMI LTSEKNEGTTFSIRIPYEPKEENHD*" /label="maeL CDS" gene 2741238..2742839 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /label="maeL gene" CDS 2742832..2743539 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator for malate metabolism [MaeL]" /protein_id="NP_391031.1" /db_xref="EnsemblGenomes-Gn:BSU31530" /db_xref="EnsemblGenomes-Tr:CAB15142" /db_xref="GOA:O05251" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12348" /db_xref="UniProtKB/Swiss-Prot:O05251" /translation="MINVLIVEDDPMVGELNKRYLSQIDGFQLKGIASSFQSALHILG EHHIDLILLDIYMPGKNGLELLTELRAQNEAVDVIVISAASELDVIKKTLRYGAVDYL IKPFEFERFQTALSDYRRKQKVYSTHRNMSQKELDAELFQKKEATEKVQLPKGLTKST LKLIWSSIQSFENESFTTEDLAKHTEISQVSIRKYLKFLEDIQVLNVEMAYGTIGRPV FQYNVNNSNINGIKQYL*" /label="maeM CDS" gene 2742832..2743539 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /label="maeM gene" downshifts 2743524 /Source="Nicolas_upshifts" /id="D1635" /incds=0 /nref=173 /ntot=245 /MaxReadThrough="1.97489" /MaxDrop="5.86018" /score="19.9464971" /energy="-15.3" /TU="NA" /idTUdmin="U2458" /TUdmin=2660 /isTUend="FALSE" /label="downshifts" promotor_-35 2743703..2743710 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2743721..2744010 /Source="Nicolas_S_feature" /locus_tag="new_3239640_3239929" /HighExp="T1.30H, T1.0H, T2.30H, T2.0H, M9-stat, S1, T3.0H, T3.30H, T0.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1208" upshifts 2743721 /Source="Nicolas_upshifts" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2743725..2743744 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2744011..2745090 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in guanosine transport" /protein_id="NP_391032.2" /db_xref="EnsemblGenomes-Gn:BSU31540" /db_xref="EnsemblGenomes-Tr:CAB15143" /db_xref="GOA:O05252" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12349" /db_xref="UniProtKB/Swiss-Prot:O05252" /translation="MNKRKIGLAMSLVIAAGTILGACGNSEKSSGSGEGKNKFSVAMV TDVGGVDDKSFNQSAWEGIQAFGKENGLKKGKNGYDYLQSKSDADYTTNLNKLARENF DLIYGVGYLMEDSISEIADQRKNTNFAIIDAVVDKDNVASITFKEQEGSFLVGVAAAL SSKSGKIGFVGGMESELIKKFEVGFRAGVQAVNPKAVVEVKYAGGFDKADVGKATAES MYKSGVDVIYHSAGATGTGVFTEAKNLKKEDPKRDVWVIGVDKDQYAEGQVEGTDDNV TLTSMVKKVDTVVEDVTKKASDGKFPGGETLTYGLDQDGVGISPSKQNLSDDVIKAVD KWKKKIIDGLEIPATEKELKTFKAE*" /label="nupN CDS" gene 2744011..2745090 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /label="nupN gene" CDS 2745166..2746698 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanosine ABC transporter (ATP-binding protein)" /protein_id="NP_391033.1" /db_xref="EnsemblGenomes-Gn:BSU31550" /db_xref="EnsemblGenomes-Tr:CAB15144" /db_xref="GOA:O05253" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12350" /db_xref="UniProtKB/Swiss-Prot:O05253" /translation="MEYVIEMLNIRKAFPGIVANDNINLQVKKGEIHALLGENGAGKS TLMNVLFGLYQPERGEIRVRGEKVHINSPNKANDLGIGMVHQHFMLVDTFTVAENIIL GKEPKKFGRIDRKRAGQEVQDISDRYGLQIHPEAKAADISVGMQQRAEILKTLYRGAD ILIFDEPTAVLTPHEIKELMQIMKNLVKEGKSIILITHKLKEIMEICDRVTVIRKGKG IKTLDVRDTNQDELASLMVGREVSFKTEKRAAQPGAEVLAIDGITVKDTRGIETVRDL SLSVKAGEIVGIAGVDGNGQSELIEAVTGLRKTDSGTITLNGKQIQNLTPRKITESGI GHIPQDRHKHGLVLDFPIGENILLQSYYKKPYSALGVLHKGEMYKKARSLITEYDVRT PDEYTHARALSGGNQQKAIIGREIDRNPDLLIAAQPTRGLDVGAIEFVHKKLIEQRDA GKAVLLLSFELEEIMNLSDRIAVIFEGRIIASVNPQETTEQELGLLMAGSTQKEAGKA NG*" /label="nupO CDS" gene 2745166..2746698 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /label="nupO gene" CDS 2746691..2747737 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391034.1" /db_xref="EnsemblGenomes-Gn:BSU31560" /db_xref="EnsemblGenomes-Tr:CAB15145" /db_xref="GOA:O05254" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR002229" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12351" /db_xref="UniProtKB/Swiss-Prot:O05254" /translation="MVKRLSHLLVPLIAIILGLAAGALIMLVSGYSVASGYSALWNGI FGEIYYVGETIRQITPYILSGLAVAFAFRTGLFNIGVEGQLLVGWTAAVWVGTAFDGP AYIHLPLALITAAAAGGLWGFIPGILKARFYVHEVIVTIMMNYIALHMTNYIISNVLT DHQDKTGKIHESASLRSPFLEQITDYSRLHLGIIVALLAAVIMWFIINKSTKGFELRA VGFNQHASQYAGMSVRKNIMTSMLISGAFAGLAGAMEGLGTFEYAAVKGAFTGVGFDG IAVALLGGNTAVGVVLAACLLGGLKIGALNMPIESGVPSEVVDIVIAIIILFVASSYA IRFVMGKLKKKGAN*" /label="nupP CDS" gene 2746691..2747737 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /label="nupP gene" CDS 2747738..2748697 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391035.1" /db_xref="EnsemblGenomes-Gn:BSU31570" /db_xref="EnsemblGenomes-Tr:CAB15146" /db_xref="GOA:O05255" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12352" /db_xref="UniProtKB/Swiss-Prot:O05255" /translation="MDIVQILSIIVPATLVYAAPLILTALGGVFSERSGVVNIGLEGL MIIGAFTSVLFNLFFGQELGAAAPWLSLLAAMAAGALFSLIHAAAAISFRADQTVSGV AINMLALGATLFIVKLIYGKAQTDKIPEPFYKTKIPGLGDIPVLGKIFFSDVYYTSIL AIALAFISWFILFKTPFGLRIRSVGEHPMAADTMGINVYKMRYIGVMISGLFGGLGGG VYASTIALDFTHSTISGQGFIALAALVFGKWHPIGALGAALFFGFAQSLSIIGSLLPL FKDIPNVYMLMAPYILTILALTGFIGRADAPKANGVPYIKGKR*" /label="nupQ CDS" gene 2747738..2748697 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /label="nupQ gene" S_feature 2748698..2748819 /Source="Nicolas_S_feature" /locus_tag="new_3244617_3244738" /HighExp="S1, BT, M9-stat, T1.30H, S2, LoTm, T1.0H, T2.30H, T2.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1209" promotor_-35 2748792..2748795 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2748810..2748829 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2748821 /Source="Nicolas_upshifts" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="upshifts" CDS 2748851..2750197 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/malate symporter" /protein_id="NP_391036.1" /db_xref="EnsemblGenomes-Gn:BSU31580" /db_xref="EnsemblGenomes-Tr:CAB15147" /db_xref="GOA:O05256" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12353" /db_xref="UniProtKB/Swiss-Prot:O05256" /translation="MGAIPKTGTISPEQKDSQEKNLFQKIWSWEIGVIPLPLYTVLAV IIILAAYYNELPANMLGGFAIIMILGVFLGDIGQRIPILKDIGGPAILSLFVPSFLVF YNVLNSTSLDAVTNLMKTSNFLYFYIACLVVGSILGMNRIVLIQGFIRMFVPLVAGTI AAVAAGILVGFIFGYSAYDSFFFVVVPIIAGGIGEGILPLSIAYSQILGSSADVFVSQ LVPAAIIGNVFAIICAALMKKLGDKRPDLNGNGRLVKSKKANEIFNQKEAEAKIDFKL MGAGVLLACTFFIFGGLLEKFIFIPGAILMIISAAAVKYANILPKKMEEGAYQLYKFI SSSFTWPLMVGLGILFIPLDDVASVISIPFVIICISVVIAMIGSGYFVGKLMNMYPVE SAIVTCCHSGLGGTGDVAILSASGRMGLMPFAQISTRLGGAGTVICATVLLRFFTS*" /label="maeN CDS" gene 2748851..2750197 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /label="maeN gene" downshifts 2750180 /Source="Nicolas_upshifts" /id="D1636" /incds=0 /nref=68 /ntot=109 /MaxReadThrough="0.286069999999999" /MaxDrop="6.51197" /score="36.240717" /energy="-12.2" /TU="NA" /idTUdmin="U2461" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS complement(2750233..2750448) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391037.1" /db_xref="EnsemblGenomes-Gn:BSU31590" /db_xref="EnsemblGenomes-Tr:CAB15148" /db_xref="GOA:O05257" /db_xref="SubtiList:BG12354" /db_xref="UniProtKB/Swiss-Prot:O05257" /translation="MKTKVVMCSGLFCSVFAGAFMLNQYDGRSGVAACDEWELYLLEH HLSARMSETESKDLPFGPREYIRIVNK*" /label="yufS CDS" gene complement(2750233..2750448) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /label="yufS gene" promotor_-35 2750388..2750394 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2750408..2750419 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2750412 /Source="Nicolas_upshifts" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2750459..2750477) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2750466) /Source="Nicolas_upshifts" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2750491..2750498 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2750493..2750498) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2750513..2750608 /Source="Nicolas_S_feature" /locus_tag="new_3246432_3246527" /HighExp="G180, Diami, G150, Oxctl, G135, H2O2, Paraq, MG 60, MG 15, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1210" promotor_-10 2750513..2750532 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2750513 /Source="Nicolas_upshifts" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2750571..2750575 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2750591..2750610 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2750610..2750759 /Source="Nicolas_S_feature" /locus_tag="new_3246529_3246678" /HighExp="G135, G180, Diami, G150, H2O2, Oxctl, LBGexp, Paraq, Salt, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1211" upshifts 2750610 /Source="Nicolas_upshifts" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" CDS 2750679..2753084 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium transporter component of a Na+/H+ antiporter" /protein_id="NP_391038.2" /db_xref="EnsemblGenomes-Gn:BSU31600" /db_xref="EnsemblGenomes-Tr:CAB15149" /db_xref="GOA:Q9K2S2" /db_xref="InterPro:IPR001516" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR005663" /db_xref="InterPro:IPR018393" /db_xref="InterPro:IPR025383" /db_xref="SubtiList:BG12355" /db_xref="UniProtKB/Swiss-Prot:Q9K2S2" /translation="MQLLHLAILSPFLFAFIIPFLAKYAKRVHTGWFVLILPVLLFIY FLPMIRMTQSGETLRSVLEWIPSLGINFTVYIDGLGLLFALLITGIGSLVTLYSIFYL SKEKEQLGPFYVYLLMFMGAMLGVVLVDNVMVLYMFWELTSLSSFLLIGYWYKREKSR YGAAKSLLITVSGGLCMLGGFILLYLITDSFSIREMVHQVQLIAGHELFIPAMILILL GAFTKSAQFPFYIWLPDAMEAPTPVSAYLHSATMVKAGIYVIARFSPIFAFSAQWFWI VSLVGLFTMVWGSFHAVKQTDLKSILAFSTVSQLGMIISMLGVSAAALHYGHTEYYTV AAMAAIFHLINHATFKGSLFMAVGIIDHETGTRDIRKLGGLMAIMPITFTISLIGTFS MAGLPPFNGFLSKEMFFTSMLRVTHFDLFNVQTWGVLFPLFAWIGSVFTFIYSMKLLF KTFRGNYQPEQLEKQAHEAPVGMLVPPVILVALAVSLFFFPNILSYSLIEPAMNSIYP TLLDGHEKFHVHISQWHGVTTELLMTAGIVVIGTIGYLSLNKWKGIYKLFPSKLTLNR LYDKLLTMMEKGSYRVTKQYMTGFLRDYLLYIFAGFIILIGGAFAIKGGFSFKTEGMA KIGVYEIILTLVMISATVATVFARSRLTAIIALGVVGYTLALFFVIFRAPDLALTQLV IETISVALFLLCFYHLPKLRLKTKTRTFRMTNFIISLGVGVIVTLLGIASSSQRTKDS IASFFVKHSHDLGGGDNVVNVILVDFRGFDTMFEITVLTIAALGIYSMIKTKVKEEGK SGE*" /label="mrpA CDS" gene 2750679..2753084 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /label="mrpA gene" CDS 2753077..2753508 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter complex" /protein_id="NP_391039.1" /db_xref="EnsemblGenomes-Gn:BSU31610" /db_xref="EnsemblGenomes-Tr:CAB15150" /db_xref="GOA:O05259" /db_xref="InterPro:IPR005281" /db_xref="InterPro:IPR007182" /db_xref="SubtiList:BG12356" /db_xref="UniProtKB/Swiss-Prot:O05259" /translation="MNEQKTNDLILQTATKLVSFIILLFSFYLFLSGHNAPGGGFVGG LITSSSIVLLLLAYDLKTVRSLLPVNFIYVAGAGLLLAVLTGVGSFVFGAPFLTHTFG YFQLPILGKTELATATIFDLGVYLVVVGITMTIIQTIGEEE*" /label="mrpB CDS" gene 2753077..2753508 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /label="mrpB gene" CDS 2753508..2753849 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of Na+/H+ antiporter" /protein_id="NP_391040.2" /db_xref="EnsemblGenomes-Gn:BSU31620" /db_xref="EnsemblGenomes-Tr:CAB15151" /db_xref="GOA:O05260" /db_xref="SubtiList:BG12357" /db_xref="UniProtKB/Swiss-Prot:O05260" /translation="MEILMAVLAGIIFMAATYLLLSKSLLRVIIGTALLSHGVHLMLL TMGGLKKGAAPILSEHAKSFVDPLPQALILTAIVISFGVTSFILVMAFRAYQELKSDD MDQMRGNDQHE*" /label="mrpC CDS" gene 2753508..2753849 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /label="mrpC gene" promotor_no_box 2753740..2753840 /Source="Nicolas_upshift_promotors" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2753800 /Source="Nicolas_upshifts" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" CDS 2753842..2755323 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton transporter component of Na+/H+ antiporter" /protein_id="NP_391041.3" /db_xref="EnsemblGenomes-Gn:BSU31630" /db_xref="EnsemblGenomes-Tr:CAB15152" /db_xref="GOA:O05229" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR003918" /db_xref="InterPro:IPR004775" /db_xref="SubtiList:BG12345" /db_xref="UniProtKB/Swiss-Prot:O05229" /translation="MNNFVILPILIPLLSAILLIFMTKNLMLMRIFSTAASAIGIVIS GILVQTVFTKGIQTLSLGGWKAPYGIVLAADQFASLLVLTTAIIGLLVGLYSFRSVGE KRERSFYYSGVQFLLAGVSGAFLTGDLFNMYVFFELLLIASYMLIVLGGTKIQLRESL KYIVFNIVSSALFVIGVGFLYAVTGTLNMADLSVKISESGQTGLITVIGVLLLLVFGM KGGIFPLYFWLPGSYYAPPAAISALFGALLTKVGLYAITRVFTLIFIHDTAFTHQLMI WLAALTVIFGVIGSLAYSNVMKIVIYNIITAVGVILFGVAVHTPASIQGAIYYLIHDM LIKGALFMLAGTLIALTGTASLHKMGGLIKRYPVLGWMFFISAISLAGIPPLSGFVGK FKIAEGGFAEGEFTISMLILLSSLLVLYSVLRIFIHAFWGEEKETPKPNHRTAKGLLY PAAIFLLLSLLFGLGTEWVSPYVDQAAETLLNPEKYIEAVLKE*" /label="mrpD CDS" gene 2753842..2755323 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /label="mrpD gene" S_feature complement(2754575..2756443) /Source="Nicolas_S_feature" /locus_tag="new_3250494_3252362_c" /HighExp="S2, Lbstat, T5.0H, T3.30H, S3, T4.0H, T3.0H, T2.30H, S1, T2.0H" /AntisenseName="mrpD" /AntisenseCor="-0.59706140653928796" /AntisenseRegPval="-26.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1212" CDS 2755329..2755805 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 15849754, 16233411, 16850406, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 15849754, 16233411, 16850406, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="YP_054591.2" /db_xref="EnsemblGenomes-Gn:BSU31640" /db_xref="EnsemblGenomes-Tr:CAE01465" /db_xref="GOA:Q7WY60" /db_xref="InterPro:IPR002758" /db_xref="SubtiList:BG14181" /db_xref="UniProtKB/Swiss-Prot:Q7WY60" /translation="MAFQILLNVFLAFCWMFLSNSPSAAGFITGYILGMLSLFFFRRF FTRQFYLWKLISIIKLCFIFIKELYLANVSVMKSVLSPKLNIRPGIFAFKTELTKDWE ITMLSLLITLTPGTLVMDISDDRTILYIHAMDIEDAEKAIFDIRESFEKAIQEVSR*" /label="mrpE CDS" gene 2755329..2755805 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /label="mrpE gene" CDS 2755805..2756089 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 11356194, 12682299, 15019740, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 11356194, 12682299, 15019740, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter for Na+ and cholate" /protein_id="NP_391043.2" /db_xref="EnsemblGenomes-Gn:BSU31650" /db_xref="EnsemblGenomes-Tr:CAB15153" /db_xref="GOA:O05228" /db_xref="InterPro:IPR007208" /db_xref="SubtiList:BG12344" /db_xref="UniProtKB/Swiss-Prot:O05228" /translation="MFTLILQIALGIMAVSTFLYVIRVIKGPTVPDRVVALDAIGINL IAITALVSILLKTSAFLDIILLLGILSFIGTIAFSKFLEKGEIIENDRNR*" /label="mrpF CDS" gene 2755805..2756089 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /label="mrpF gene" CDS 2756073..2756447 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 15019740, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 15019740, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="NP_391044.1" /db_xref="EnsemblGenomes-Gn:BSU31660" /db_xref="EnsemblGenomes-Tr:CAB15154" /db_xref="GOA:O05227" /db_xref="InterPro:IPR005133" /db_xref="SubtiList:BG12343" /db_xref="UniProtKB/Swiss-Prot:O05227" /translation="MIETAKVVVAVFILLGALICLIASFGVLRLPDVFTRAHAASKGS TLGVNMILLGVFFYLWFVTGELSAKILLGILFIFITSPIGGHLICRAAYNSGVKLDER SVQDDYNGIRNFVIKRKEDSYL*" /label="mrpG CDS" gene 2756073..2756447 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /label="mrpG gene" downshifts 2756418 /Source="Nicolas_upshifts" /id="D1637" /incds=0 /nref=86 /ntot=185 /MaxReadThrough="1.46493" /MaxDrop="6.023" /score="32.1865197" /energy="-12.7" /TU="NA" /idTUdmin="U2464" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2756486..2756866) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /EC_number="3.1.-.-" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25010423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proofreading thioesterase in bacillibactin biosynthesis" /protein_id="NP_391045.2" /db_xref="EnsemblGenomes-Gn:BSU31670" /db_xref="EnsemblGenomes-Tr:CAB15155" /db_xref="GOA:P14205" /db_xref="InterPro:IPR003736" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10382" /db_xref="UniProtKB/Swiss-Prot:P14205" /translation="MDMKHTLLEALGIEIVENTAERCVAVMPVDHRTVQPFGYLHGGA SVALAETAASAGAQNLIDHTTQACVGLEINANHLKSVKEGTVKAIAEPVHIGRTTIVY HIHIYDEQERLICISRCTLAVIKK*" /label="yuxO CDS" gene complement(2756486..2756866) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /label="yuxO gene" downshifts complement(2756488) /Source="Nicolas_upshifts" /id="D1638" /incds=0 /nref=41 /ntot=206 /MaxReadThrough="4.53972" /MaxDrop="3.98532" /score="-4.4938943" /energy="-12.7" /TU="U2469" /idTUdmin="U2469" /TUdmin="-1050" /isTUend="FALSE" /label="downshifts" CDS complement(2756885..2757529) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response quorum-sensing regulator" /protein_id="NP_391046.1" /db_xref="EnsemblGenomes-Gn:BSU31680" /db_xref="EnsemblGenomes-Tr:CAB15156" /db_xref="GOA:P14204" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2KRF" /db_xref="PDB:3ULQ" /db_xref="SubtiList:BG10381" /db_xref="UniProtKB/Swiss-Prot:P14204" /translation="MKKILVIDDHPAVMEGTKTILETDSNLSVDCLSPEPSEQFIKQH DFSSYDLILMDLNLGGEVNGMELSKQILQENPHCKIIVYTGYEVEDYFEEAIRAGLHG AISKTESKEKITQYIYHVLNGEILVDFAYFKQLMTQQKTKPAPSSQKEQDVLTPRECL ILQEVEKGFTNQEIADALHLSKRSIEYSLTSIFNKLNVGSRTEAVLIAKSDGVL*" /label="comA CDS" gene complement(2756885..2757529) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /label="comA gene" S_feature complement(2757530..2757609) /Source="Nicolas_S_feature" /locus_tag="new_3253449_3253528_c" /HighExp="S2, Lbstat, M0t90, M40t90, MG 5, S1, ferm, T1.30H, nit, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1213" CDS complement(2757610..2759919) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /EC_number="2.7.-.-" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7698645, 7855425, 10419951, 14679219, 15066026, 16091050, 16787201, 20208433, 24130811; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_391047.2" /db_xref="EnsemblGenomes-Gn:BSU31690" /db_xref="EnsemblGenomes-Tr:CAB15157" /db_xref="GOA:Q99027" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10380" /db_xref="UniProtKB/Swiss-Prot:Q99027" /translation="MKNLIKKFTIAVIVLSILYISYTTYISMNGIIIGTKIHKNDKSQ FMIEEISESSYGQFVGLRQGDIILKINKEKPSDKHLKWGYLSHINSLDILRSGKKIHL KDFDLVTLNRPYSFFLFVLPLFFYFLSIICIFYILKVNKKRRSFAAYILILLLLDISI AYISAGGPFRGHIINRYINLFTFISSPILYLQFIQRYLGEIGKTFLNRISFLYIIPIF NLGIEFFQDYLQVDIDFLATLNLVSFATLTLFSFSAIYLHLNKYKYAEHSFILKLLIL TNTLSFAPFLIFFVLPIIFTGNYIFPALASASLLVLIPFGLVYQFVANKMFDIEFILG RMRYYALLAMIPTLLIVGALVLFDVMDIQMNPVRQTVFFFVVMFAVFYFKEVMDFKFR LKRFSEKFNYQDSIFKYTQLMRGVTSLQQVFKELKNTILDVLLVSKAYTFEVTPDHKV IFLDKHEVGPDWNFYQEEFENVTSEIGKIIEVNQGFLMKVGERGGSSYVLLCLSNINT PRLTRDEISWLKTLSFYTSVSMENVLHIEELMEHLKDLKQEGTNPIWLKKLMFAIEEK QRSGLARDLHDSVLQDLISLKRQCELFLGDFKKDDNPCREEVQDKLVQMNEQMSDVIS MTRETCHELRPQLLYDLGLVKALSKLVAQQQERVPFHIRLNTGRFTASLDLDSQLNLY RIIQEFLSNAVKHSQATDVLIMLISIQNKIVLHYEDDGVGFDQEKNTEHSMSMGLSGI KERVRALDGRLRIETSEGKGFKADIEIEL*" /label="comP CDS" gene complement(2757610..2759919) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /label="comP gene" promotor_-35 2758604..2758611 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2758625..2758644 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2758640 /Source="Nicolas_upshifts" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 2759513..2760484 /Source="Nicolas_S_feature" /locus_tag="new_3255432_3256404" /HighExp="S8, C30, S7, Gly, Lbstat, Fru, C90, Pyr, G135, M/G" /AntisenseName="comX" /AntisenseCor="-2.6572990440080099E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.606" /TUlongSig="NA" /TUlongPSig="NA" /label="S1214" upshifts 2759513 /Source="Nicolas_upshifts" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2759525..2759541 /Source="Nicolas_upshift_promotors" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2759934..2760101) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484; Product type f: factor" /codon_start=1 /transl_table=11 /product="competence pheromone precursor (pheromone peptide aa 46->55, geranyl-modified)" /protein_id="NP_391048.1" /db_xref="EnsemblGenomes-Gn:BSU31700" /db_xref="EnsemblGenomes-Tr:CAB15158" /db_xref="GOA:P45453" /db_xref="InterPro:IPR009233" /db_xref="SubtiList:BG11324" /db_xref="UniProtKB/Swiss-Prot:P45453" /translation="MQDLINYFLNYPEALKKLKNKEACLIGFDVQETETIIKAYNDYY LADPITRQWGD*" /label="comX CDS" gene complement(2759934..2760101) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /label="comX gene" CDS complement(2760089..2760987) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoprenyl transferase (pre-ComX modification)" /protein_id="NP_391049.2" /db_xref="EnsemblGenomes-Gn:BSU31710" /db_xref="EnsemblGenomes-Tr:CAB15159" /db_xref="GOA:P33690" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033965" /db_xref="SubtiList:BG10379" /db_xref="UniProtKB/Swiss-Prot:P33690" /translation="MKEIVEQNIFNEDLSQLLYSFIDSKETFSFAESTILHYVVFGGE NLDVATRLGAGIEILILSSDIMDDLEDEDNHHALWMKINRSESLNAALSLYTVGLTSI YSLNNNPLIFKYVLKYVNEAMQGQHDDITNKSKTEDESLEVIRLKCGSLIALANVAGV LLATGEYNETVERYSYYKGIIAQISGDYYVLLSGNRSDIEKNKHTLIYLYLKRLFNDA SEDLLYLISHKDLYYKSLLDKEKFQEKLIKAGVTQYISVLLEIYKQKCISAIEQLNLD KEKKS**RNAY*VIQRGIQDARP" /label="comQ CDS" gene complement(2760089..2760987) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /label="comQ gene" S_feature complement(2760988..2761101) /Source="Nicolas_S_feature" /locus_tag="new_3256908_3257021_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, S4, T2.30H, M0t90, S5, M40t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1215" promotor_-10 complement(2761095..2761114) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2761101) /Source="Nicolas_upshifts" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2761128..2761134) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2761172..2761312) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="pleiotropic regulator" /protein_id="NP_391050.1" /db_xref="EnsemblGenomes-Gn:BSU31720" /db_xref="EnsemblGenomes-Tr:CAB15160" /db_xref="GOA:Q99039" /db_xref="InterPro:IPR012554" /db_xref="SubtiList:BG10378" /db_xref="UniProtKB/Swiss-Prot:Q99039" /translation="MEKKLEEVKQLLFRLELDIKETTDSLRNINKSIDQLDKYNYAMK IS*" /label="degQ CDS" gene complement(2761172..2761312) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /label="degQ gene" downshifts complement(2761201) /Source="Nicolas_upshifts" /id="D1639" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="2.48672" /MaxDrop="4.10905" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2470" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2761313..2761399) /Source="Nicolas_S_feature" /locus_tag="new_3257233_3257319_c" /HighExp="S2, S4, BC, M9-stat, S5, S3, S6, BT, S8, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.843" /TUlongSig="NA" /TUlongPSig="NA" /label="S1216" promotor_-10 complement(2761383..2761402) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2761399) /Source="Nicolas_upshifts" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2761416..2761422) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2761499..2761517) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2761509) /Source="Nicolas_upshifts" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2761532..2761538) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2761534..2761659 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514001.1" /translation="MLKLRKILNLLDFNGFRIFTKQDYSPSYRIFKIEYAILGVS*" /label="hypothetical protein CDS" gene 2761534..2761659 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /label="gene" S_feature complement(2761687..2762116) /Source="Nicolas_S_feature" /locus_tag="new_3257607_3258036_c" /HighExp="LBGtran, G135, C90, Lbtran, Mt0, Lbexp, G150, G180, M40t45, C30" /AntisenseName="yuzC" /AntisenseCor="-0.77553193168722701" /AntisenseRegPval="-54.5" /CDS_PredictionProba="0.143959" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1217" promotor_-35 2761712..2761717 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2761729) /Source="Nicolas_upshifts" /id="D1640" /incds=0 /nref=23 /ntot=170 /MaxReadThrough="2.53578" /MaxDrop="3.52021" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2473" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 2761732..2761750 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2761734 /Source="Nicolas_upshifts" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="upshifts" CDS 2761773..2762141 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16321932" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391051.2" /db_xref="EnsemblGenomes-Gn:BSU31730" /db_xref="EnsemblGenomes-Tr:CAB15161" /db_xref="InterPro:IPR016559" /db_xref="SubtiList:BG14052" /db_xref="UniProtKB/Swiss-Prot:O32089" /translation="MRYRYPWFYVYPYEVRRPPAPANNIDTFIRSAKQAAGIFADAQL VLSRIAGSRELSRRILTAAEQSDKQTIRRLIKQMGVRHEVDTVFNPDGIYISLIGTQS RMILALRWSEDRNHFASIRL*" /label="cotIC CDS" gene 2761773..2762141 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /label="cotIC gene" CDS complement(2762117..2763346) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /EC_number="3.1.4.52" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17153922, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17153922, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclic di-GMP phosphodiesterase" /protein_id="NP_391052.1" /db_xref="EnsemblGenomes-Gn:BSU31740" /db_xref="EnsemblGenomes-Tr:CAB15162" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR013976" /db_xref="InterPro:IPR014408" /db_xref="InterPro:IPR035919" /db_xref="SubtiList:BG10377" /db_xref="UniProtKB/Swiss-Prot:P14203" /translation="MRVFVARQPIFNRKEQVVAYELLYRESEENVYSAKDGDQATTDL VINSFLNIGIEKLTEGKRCFVNFTESLMFSNLPTSFNPKQLVIEILEDIPITPALISR CKELKKMGYMLALDDFYAINPQDEDLLEKLMSYIDILKIDFLKTTRMERRTILQTYGC RGLIFLAEKVETRKEYKQAVQDGFQLFQGYFFSEPRIISGHDLSTHFYSYYELLNELS KEQPNIKRVTEYIERDLSLSYQILKFLNSSHSRLSQKIESIQQAIMLLGFNEIKRWIY ILSFKDLSRKGHSSKHEIIKISLIRAKLCELLARKTSRPQPASYMLIGMFSLIDTLLH REIEEIVQELPLKDEVGQALLGHQNDYYQMLELVKLIESNNWDTCSELGNQLDKEEAY ECYLEALEWCHNLMDAK*" /label="pdeH CDS" gene complement(2762117..2763346) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /label="pdeH gene" S_feature 2762142..2763455 /Source="Nicolas_S_feature" /locus_tag="new_3258062_3259375" /HighExp="S4, S5, S3, S6, LoTm, S8, S7, T5.0H, B36, Pyr" /AntisenseName="yuxH" /AntisenseCor="-0.78363066752642896" /AntisenseRegPval="-56.4" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1218" promotor_-10 complement(2763381..2763400) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2763400) /Source="Nicolas_upshifts" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="upshifts" downshifts 2763413 /Source="Nicolas_upshifts" /id="D1641" /incds=0 /nref=6 /ntot=30 /MaxReadThrough="1.76106" /MaxDrop="4.58543" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2763415..2763422) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2763483..2764955) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /EC_number="6.3.4.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4296374, 12682299, 16199587, 24564896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate phosphoribosyltransferase" /protein_id="NP_391053.1" /db_xref="EnsemblGenomes-Gn:BSU31750" /db_xref="EnsemblGenomes-Tr:CAB15163" /db_xref="GOA:O32090" /db_xref="InterPro:IPR006405" /db_xref="InterPro:IPR007229" /db_xref="InterPro:IPR036068" /db_xref="SubtiList:BG13966" /db_xref="UniProtKB/Swiss-Prot:O32090" /translation="MLEYGFKDDSLSLHTDLYQINMAETYWRDGIHEKKAIFELFFRR LPFENGYAVFAGLEKAIEYLENFKFTDSDLSYLQDELGYHEDFIEYLRGLSFTGSLYS MKEGELVFNNEPIMRVEAPLVEAQLIETALLNIVNYQTLIATKAARIKGVIGDEVALE FGTRRAHEMDAAMWGARAALIGGFSATSNVRAGKRFNIPVSGTHAHALVQAYRDEYTA FKKYAETHKDCVFLVDTYDTLRSGMPNAIRVAKEFGDRINFIGIRLDSGDLAYLSKKA RKMLDEAGFTDAKVIASSDLDEHTIMNLKAQGARIDVWGVGTKLITAYDQPALGAVYK LVAIEEDGKMVDTIKISSNPEKVTTPGRKKVYRIINQSNHHSEGDYIALYDEQVNDQK RLRMFHPVHTFISKFVTNFYAKDLHELIFEKGILCYQNPEISDIQQYVQDNLSLLWEE YKRISKPEEYPVDLSEDCWSNKMQRIHEVKSRIEEELEEE*" /label="pncB CDS" gene complement(2763483..2764955) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /label="pncB gene" downshifts complement(2763493) /Source="Nicolas_upshifts" /id="D1642" /incds=0 /nref=200 /ntot=267 /MaxReadThrough="4.08676" /MaxDrop="6.72747" /score="16.2382739" /energy="-14.5" /TU="NA" /idTUdmin="U2475" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" misc_feature 2764836..2764840 /Source="Nicolas_upshift_promotors" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2764843 /Source="Nicolas_upshifts" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2764953 /Source="Nicolas_upshifts" /id="D1643" /incds=0 /nref=1 /ntot=123 /MaxReadThrough="1.2059" /MaxDrop="3.08208" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=1540 /isTUend="FALSE" /label="downshifts" CDS complement(2764971..2765522) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /EC_number="3.5.1.19" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15135535, 17382284, 18616465, 24340054, 24512664; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinamidase; NAD salvage pathway" /protein_id="NP_391054.1" /db_xref="EnsemblGenomes-Gn:BSU31760" /db_xref="EnsemblGenomes-Tr:CAB15164" /db_xref="GOA:O32091" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG13965" /db_xref="UniProtKB/Swiss-Prot:O32091" /translation="MKKALICIDYTNDFVASDGKLTCGEPGRMIEEAIVNLTKEFITN GDYVVLAVDSHDEGDQYHPETRLFPPHNIKGTEGKDLYGKLLPLYQKHEHEPNVYYME KTRYSAFAGTDLELKLRERQIGELHLAGVCTDICVLHTAVDAYNKGFRIVVHKQAVAS FNQEGHAWALSHFANSIGAQVAE*" /label="pncA CDS" gene complement(2764971..2765522) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /label="pncA gene" promotor_-10 complement(2765544..2765563) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2765557) /Source="Nicolas_upshifts" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2765576..2765583) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2765619..2766017) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391055.1" /db_xref="EnsemblGenomes-Gn:BSU31770" /db_xref="EnsemblGenomes-Tr:CAB15165" /db_xref="InterPro:IPR012543" /db_xref="InterPro:IPR029064" /db_xref="PDB:2OHW" /db_xref="SubtiList:BG13964" /db_xref="UniProtKB/Swiss-Prot:O32092" /translation="MSEDKMDLYLQQGMYGPLETKPDERHLFLGSLRERVVLALTKGQ VLRSKPYKEAEHELKNSHNVTLLINGELQYQSYSSYIQMASRYGVPFKIVSDLQFHTP LGIVIAADIAVNRELIYIQDDIYNRSVLKS*" /label="yueI CDS" gene complement(2765619..2766017) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /label="yueI gene" S_feature complement(2766018..2766088) /Source="Nicolas_S_feature" /locus_tag="new_3261938_3262008_c" /HighExp="Etha, dia5, Diami, dia15, H2O2, LBGtran, LPhT, G135, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1219" CDS complement(2766089..2766337) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391056.1" /db_xref="EnsemblGenomes-Gn:BSU31780" /db_xref="EnsemblGenomes-Tr:CAB15166" /db_xref="InterPro:IPR020260" /db_xref="SubtiList:BG13963" /db_xref="UniProtKB/Swiss-Prot:O32093" /translation="MKIRKANINTQTGMITDVYLHENRKELRTLVAVPQLEWSTIISY EEDKATLPERLEASLRRHTEETPAGELAKKIIHWVTEM*" /label="yueH CDS" gene complement(2766089..2766337) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /label="yueH gene" promotor_-10 complement(2766360..2766379) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2766371) /Source="Nicolas_upshifts" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2766395..2766398) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2766410..2766631) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_391057.1" /db_xref="EnsemblGenomes-Gn:BSU31790" /db_xref="EnsemblGenomes-Tr:CAB15167" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13962" /db_xref="UniProtKB/Swiss-Prot:O32094" /translation="MPAIVGPIYIMSVTDNAAASFGDVFAISPKSVAHSGAGSGTFQL GDFVKINNQTSKTLFKDADITDETVSFNG*" /label="yueG CDS" gene complement(2766410..2766631) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /label="yueG gene" downshifts complement(2766437) /Source="Nicolas_upshifts" /id="D1644" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="3.65047" /MaxDrop="4.3681" /score="19.032155" /energy="-12.6" /TU="U2477,U2479,U2482" /idTUdmin="U2482" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 2766625 /Source="Nicolas_upshifts" /id="D1645" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="1.17049" /MaxDrop="3.0193" /score="-7.47675224" /energy="-6.7" /TU="NA" /idTUdmin="U2480" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2766649..2766668) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2766655) /Source="Nicolas_upshifts" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2766681..2766690) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2766691..2767800) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391058.1" /db_xref="EnsemblGenomes-Gn:BSU31800" /db_xref="EnsemblGenomes-Tr:CAB15168" /db_xref="GOA:O32095" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13961" /db_xref="UniProtKB/Swiss-Prot:O32095" /translation="MLKSKVHFWTLQILFVLLIIFVATKVSFVFQPFIVFISTLFFPM LIAGILYFIFNPVVRLLEKKIPRTLSILLIYLLFIGLLAFISASVGPIITAQVTGLFN NLPDYIKQIQALTKDLSHSQWFTWMMNQDYVSISKIEQSLTSFLQNLPQNITSSLSAV FGVVTNITLVIITVPFILFYMLKDGHRFPHLAVKILPASYRTEGLKIFKDLSDTLAAY FQGQLLICLFVGTACFIGYLIAGLPYALILGIVMAITNIIPYVGPFLGAAPAVIVGFM DSPAKALFAIIVVVIVQQLDGNLLSPLVIGKRLNTHPLTIILLLIGAGSFGGILGMIL AVPVYAVVKAFFLNIVRLIKLRQRSRLEENAKPAE*" /label="yueF CDS" gene complement(2766691..2767800) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /label="yueF gene" promotor_-35 2767452..2767459 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2767474..2767493 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2767483..2767877 /Source="Nicolas_S_feature" /locus_tag="new_3263403_3263797" /HighExp="dia15, S8, H2O2, dia5, LBGstat, Paraq, C30, S7, Diami, G180" /AntisenseName="yueF" /AntisenseCor="0.28555063485711402" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1220" upshifts 2767483 /Source="Nicolas_upshifts" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2767848..2767867) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-10" upshifts complement(2767864) /Source="Nicolas_upshifts" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="upshifts" S_feature complement(2767866..2768306) /Source="Nicolas_S_feature" /locus_tag="new_3263786_3264226_c" /HighExp="Diami, S8, H2O2, S7, C90, Paraq, Salt, S1, dia15, dia5" /AntisenseName="yuzE" /AntisenseCor="0.47136608606324898" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1221" promotor_-35 2767869..2767871 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2767879 /Source="Nicolas_upshifts" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2767881..2767886) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-35" promotor_-10 2767887..2767906 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2767915..2768304 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391059.1" /db_xref="EnsemblGenomes-Gn:BSU31810" /db_xref="EnsemblGenomes-Tr:CAB15169" /db_xref="InterPro:IPR016789" /db_xref="InterPro:IPR019270" /db_xref="SubtiList:BG14054" /db_xref="UniProtKB/Swiss-Prot:O32096" /translation="MKAVTYDTDSELAYIYVLPPKKNRNVRTEELRVNDCLLLDISQD GKIAGFECFGEAAHLCAPFAGKSRLYVKDSDGYHFRVCQHASVRSCYTVYRVTFCFSD GDYQEFAGFDLDGTMYHSAFLQRLTEK*" /label="yuzE CDS" gene 2767915..2768304 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /label="yuzE gene" CDS complement(2768345..2768581) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391060.1" /db_xref="EnsemblGenomes-Gn:BSU31820" /db_xref="EnsemblGenomes-Tr:CAB15170" /db_xref="InterPro:IPR020139" /db_xref="SubtiList:BG14055" /db_xref="UniProtKB/Swiss-Prot:O32097" /translation="MVNQGSPQLVSLVDPYVYQTIKKLIGSRFVIQTVRDTVRGRLID VKPDHITIEGARNSVCLIRIQHMISVTPDYSERV*" /label="yuzF CDS" gene complement(2768345..2768581) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /label="yuzF gene" downshifts complement(2768351) /Source="Nicolas_upshifts" /id="D1646" /incds=0 /nref=12 /ntot=37 /MaxReadThrough="5.19136" /MaxDrop="5.1675" /score="30.7642328" /energy="-9.9" /TU="U2482" /idTUdmin="U2481" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2768601..2768620) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2768615) /Source="Nicolas_upshifts" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2768617..2768757) /Source="Nicolas_S_feature" /locus_tag="new_3264537_3264677_c" /HighExp="BT, Diami, S8, Etha, Sw, C90, Salt, B36, LPhT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.998, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1222" promotor_-35 complement(2768634..2768643) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2768758..2769288) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /EC_number="3.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent phosphohydrolase" /protein_id="NP_391061.1" /db_xref="EnsemblGenomes-Gn:BSU31830" /db_xref="EnsemblGenomes-Tr:CAB15171" /db_xref="GOA:O32098" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="SubtiList:BG13960" /db_xref="UniProtKB/Swiss-Prot:O32098" /translation="MRKVTLMDVFTHPIAQKYLQRSGVAHAIACAYHAYRLSVKADIN PDLAAKAALLHDIGHYEWYTDGKWDYEKYKRNDIHAIKGAERAHKLLIRLGEEPKAAK EIALAILLHTDSYLPEGELDKNTLQQIVKKADELDEEPGGHHHYRQIDPSTARKKIEK LDQLIDQAQASVIKPV*" /label="yueE CDS" gene complement(2768758..2769288) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /label="yueE gene" promotor_-10 complement(2769308..2769327) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-10" upshifts complement(2769319) /Source="Nicolas_upshifts" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="upshifts" S_feature complement(2769321..2769407) /Source="Nicolas_S_feature" /locus_tag="new_3265241_3265327_c" /HighExp="BT, S8, S6, S7, B36, Etha, S5, S4, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1223" promotor_-35 complement(2769339..2769347) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-35" promotor_-10 complement(2769402..2769421) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2769409) /Source="Nicolas_upshifts" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2769435..2769444) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2769486..2770217) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /EC_number="1.1.1.320" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11745140, 21670841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="benzil reductase (benzoin forming)" /protein_id="NP_391062.1" /db_xref="EnsemblGenomes-Gn:BSU31840" /db_xref="EnsemblGenomes-Tr:CAB15172" /db_xref="GOA:O32099" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13959" /db_xref="UniProtKB/Swiss-Prot:O32099" /translation="MELYIITGASKGLGQAIALQALEKGHEVHALSRTKTDVSHKKLT QHQIDLINLEEAEQQFETLLSSIDSDRYSGITLINNAGMVTPIKRAGEASLDELQRHY QLNLTAPVLLSQLFTKRFASYSGKKTVVNITSGAAKNPYKGWSAYCSSKAGLDMFTRT FGFEQEDEELPVNMISFSPGVMDTEMQAVIRSSSKKDFHHIERFRKLNETGSLRSPDF IAGTLLSLLEKGTENGRIYDIKEFL*" /label="bznD CDS" gene complement(2769486..2770217) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /label="bznD gene" downshifts complement(2769516) /Source="Nicolas_upshifts" /id="D1647" /incds=0 /nref=183 /ntot=253 /MaxReadThrough="2.76356" /MaxDrop="5.18507" /score="30.7642328" /energy="-9.9" /TU="NA" /idTUdmin="U2484" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2770232..2770251) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2770243) /Source="Nicolas_upshifts" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2770266..2770273) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2770280..2770735) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YueC protein" /protein_id="NP_391063.1" /db_xref="EnsemblGenomes-Gn:BSU31850" /db_xref="EnsemblGenomes-Tr:CAB15173" /db_xref="GOA:O32100" /db_xref="InterPro:IPR018920" /db_xref="InterPro:IPR020212" /db_xref="SubtiList:BG13958" /db_xref="UniProtKB/Swiss-Prot:O32100" /translation="MLSFSLFIPSAAAAQTEENTDVAPNQYEKKDIEIDTNYLHEDTY YEEKTELPEEQKDITFDKPKDKDAELIKDLFTSTNAEDSNTIAAQSKQLGITFAEKPM TKTSSTETEDEQETSSLLLPMIYVVLILLGIAGIVFLIPKVTAQENKKA*" /label="yueC CDS" gene complement(2770280..2770735) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /label="yueC gene" promotor_-35 2770688..2770694 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2770709..2770727 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2770717..2773084 /Source="Nicolas_S_feature" /locus_tag="new_3266637_3269004" /HighExp="Etha, Gly, Sw, Salt, LoTm, C30, BT, HiTm, Mal, G135" /AntisenseName="yueB" /AntisenseCor="-9.3455707286730305E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1224" upshifts 2770717 /Source="Nicolas_upshifts" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2770767..2773997) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022, 27179995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022, 27179995; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system; calcium-dependent phage SPP1 attachment site" /protein_id="NP_391064.1" /db_xref="EnsemblGenomes-Gn:BSU31860" /db_xref="EnsemblGenomes-Tr:CAB15174" /db_xref="GOA:O32101" /db_xref="InterPro:IPR023838" /db_xref="SubtiList:BG13957" /db_xref="UniProtKB/Swiss-Prot:O32101" /translation="MTEQRKSLIKLISAVIIILLLPVLFFRFIGDDPTKKAVNSTRQI AVVNEDTGVLSDEVKSDEEDKSAQFGKEVAAVLGERPDYSWTVVNRSAAETGLASKKY DAIVYIPSDFSKNILSYDKDHPQKATLEFSIQDNLNAVNKEKVQRELEDAQKTMNKKM SALYWNFVSQKVDNIRGEFDKIVNKESEFQNVMYNFYKPSSNDLAGEIKQQKDLIDEL KKSMNEAQGTTKEKASTAEEAKNTLKEFIDTVERYKEYQENQKKLLLAAQDSTQQQIR TGLDAIQAQQKANQFSERMSGLATGIGQAKTQIGLTNLALNNAEKLRQNQVPLQEMGM KKIENDMFNAFLSRYKSQYEAIKYQNLNQLQENIGKNRLSLLKPKESDEKEDGEDTSD NKDDTDKEDIEDIKLDLEKQRDELKNVATEIKDISEGLKEPEQEKPTTPDAEEPSTDD SPNTEEPSNDIPTSDDQPTNEDTGSSEEGTQDNGSQNDVQTNIETGQKHQESSKNVPE QDTNTENTGTSKTDFSLIELADENDGSNQSDGLQGDGADGETDISGAKKRLNEAAIKL EEIENALQEKQEEHNNKLEKHIDELNQEIKELNKTVSKLNDQIGDLTKKLVDFDNNVN DAYRLIYNLEDEIIQTLQSRGYIDQKEKLSSIFSSRIETDNISNLMKYYNSLNLYKST LNDNLDLGSLTIIKGEVIQEQDGNVQSVLALTPEESASWEALKNNTMQTDEDINSFID GMTKFADDYSGYIRDSQAGVLDELTKISESAAKASEQLVTGATQESATFSNDGLSGTM ALSVQDTVGQEVLQMSDMMGSLSDRQSGIIDYTTNMQQSVNDVQAKADTLNNNWGKNV ASTKLVRNDVYGILGNTLVDGQNNGYVYDYLANPLKISGEVPEEKIQTVPPVVILVIV LISSLLIGYFSSYYQNAPLLVKGALFGILNILVGLMISLFGLNIYSLPDDQTIKWSVF TILLLVASSAFIRTAFRFGSIPGWVASAAMILFYVAPLIDLIMPNFTFEDPVSKVYID IQYGTGHLFTMGITVLLIITVIAVALPLIIRLMAEHTAESDETYEA*" /label="yueB CDS" gene complement(2770767..2773997) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /label="yueB gene" CDS complement(2773994..2778481) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system FtsK/SpoIIIE family ATPase" /protein_id="NP_391066.2" /db_xref="EnsemblGenomes-Gn:BSU31875" /db_xref="EnsemblGenomes-Tr:CAB15176" /db_xref="GOA:C0SPA7" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR022206" /db_xref="InterPro:IPR023839" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12375" /db_xref="UniProtKB/Swiss-Prot:C0SPA7" /translation="MSLLWVFYQNNVQKLNLSNLPSSHPVTIGPDVKDSVTISTIPFN SGVISLKRKESGGQYEVFLGNDCLGTIETDISFTLQTDQQDIRLILTGSEPEKSVYFT GNRDEIVCSSEKTNADIYLNPQDFAFAEQSTFSLLRAGGSWSVRPESGTIFLNGEKIN ANTPLKPGDEIFWNFTQMRVTEQDLLEIVHYAQFETALTETVKPSTEMQKKYPQYRRT PRMVYDLPDDRVSFSFPSQESDQTNRGLWLVILPPLVMLIVMGVVAIIQPRGIFILVS LAMFMMTLITSTVQYFRDKNQRKKREEKRERVYKLYLDNKRKELQALAEKQKQVLEFH FPSFEQMKYLTSEISDRIWEKSLESKDYLQLRLGTGTVPSSYEINMSGGDLANRDIDD LMEKSQHMQRVYKDIRNAPVTVDLAEGPMGLVGKSQIVKNEIHQLIGQLSFFNSYHDL RFVFIFHEEEYKDWEWMKWLPQFQMPHIYAKGFIYNEQTRDQLLSSLYELIRERDLED DKEKLQFKPHFVFVITNQQLISEHVILEYLEGQHEHLGISTIVAAETKESLSENITTL VRYINEHEGDILIQKKKAVRIPFRLDHHQREDNERFSRTLRTLNHQVGITNSIPETVS FLELFHAKEVKEIGIQQRWLTSESSKSLSVPIGYKGKDDIVYLNLHEKAHGPHGLLAG TTGSGKSEFLQTYILSLAVHFHPHEAAFLLIDYKGGGMAQPFRNIPHLLGTITNIEGS KNFSMRALASIKSELKKRQRLFDQYQVNHINDYTKLYKQGKAEVAMPHLFLISDEFAE LKSEEPDFIRELVSAARIGRSLGVHLILATQKPGGIIDDQIWSNSRFKVALKVQDATD SKEILKNSDAANITVTGRGYLQVGNNEVYELFQSAWSGAPYLEEVYGTEDEIAIVTDT GLIPLSEVDTEDNAKKDVQTEIEAVVDEIERIQDEMGIEKLPSPWLPPLAERIPRTLF PSNEKDHFHFAYVDEPDLQRQAPIAYKMMEDGNIGIFGSSGYGKSIAAATFLMSFADV YTPEELHVYIFDFGNGTLLPLAKLPHTADYFLMDQSRKIEKFMIRIKEEIDRRKRLFR EKEISHIKMYNALSEEELPFIFITIDNFDIVKDEMHELESEFVQLSRDGQSLGIYFML TATRVNAVRQSLLNNLKTKIVHYLMDQSEGYSIYGRPKFNLEPIPGRVIIQKEELYFA QMFLPVDADDDIGMFNELKSDVQKLQGRFASMEQPAPIPMLPESLSTRELSIRFKLER KPLSVPIGLHEETVSPVYFDLGKHKHCLILGQTQRGKTNVLKVMLEHLIDDETEMIGL FDSIDRGLSHYAKESDVSYLETKEDIEQWIETAEDIFKTREAMYVEAVRQGDAQNLRF SQVVLMIDGITRFQQTIDTRIQDRLANFMKSYAHLGFSFIPGGNHSEFSKGYDSLTTE MKQIRHAILLMKKSEQNVIPLPYQRQEPEIQPGFGYVVENGKEQKVQIPLCSAERESA R*" /label="yukAB CDS" gene complement(2773994..2778481) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /label="yukAB gene" promotor_-35 2777756..2777762 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2777777..2777795 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2777783..2778745 /Source="Nicolas_S_feature" /locus_tag="new_3273703_3274665" /HighExp="Etha, Sw, Gly, Salt, B60, M9-stat, LoTm, T0.30H, BT, LPhT" /AntisenseName="yukB" /AntisenseCor="-0.26212584196591598" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1225" upshifts 2777783 /Source="Nicolas_upshifts" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2778542..2779897) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /function="11.1: Protein and peptide secretion and trafficking" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukC protein" /protein_id="NP_391067.1" /db_xref="EnsemblGenomes-Gn:BSU31890" /db_xref="EnsemblGenomes-Tr:CAB15177" /db_xref="GOA:P71070" /db_xref="InterPro:IPR018778" /db_xref="SubtiList:BG12376" /db_xref="UniProtKB/Swiss-Prot:P71070" /translation="MSGEQKSYLENQLEAVAEKTDAGYTFTFQREKIKLLDGLEANVI KDINPFFHKEIDVTDDEVIITIQPPSSYKAFRFMKAKDKKSKWQFAYQLVQAVQQHNL SRLNLIVAPENIVFDKGLTPYFLHYGVKESIPPYERDEERVWQELKAAAALAVDGAFA FEDYLKFNETLTFSAEAKAILDAESYDDLLELIQTHIDELEAKAKTYIHIPRKKWNIQ RYIGLGLIVLLVPALIYSMYALFFAQPKHQAIVDSNRAFLNKQYSEVISTLSKYDAES LPESVQYQLATSYVEVENLGSAKTKNIENNLVTLQSDPQHFLYWIDYGRGEYKEAISI GRKLEYNDYIYFALAKYKQQLLSEDTNDEDIQKELDSVNSELEKAQKERQENKQSNSE TSLVDTSEEQTQTDEEKQAEEKAAEEKAAAEEKAKKEEQKEKEDEKKETEKKDEKKDD K*" /label="yukC CDS" gene complement(2778542..2779897) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /label="yukC gene" downshifts complement(2778563) /Source="Nicolas_upshifts" /id="D1648" /incds=0 /nref=5 /ntot=116 /MaxReadThrough="6.33518" /MaxDrop="3.1562" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=5823 /isTUend="FALSE" /label="downshifts" CDS complement(2779912..2780151) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /function="11.1: Protein and peptide secretion and trafficking" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukD protein" /protein_id="NP_391068.1" /db_xref="EnsemblGenomes-Gn:BSU31900" /db_xref="EnsemblGenomes-Tr:CAB15178" /db_xref="InterPro:IPR014921" /db_xref="InterPro:IPR024962" /db_xref="InterPro:IPR029071" /db_xref="PDB:2BPS" /db_xref="SubtiList:BG12377" /db_xref="UniProtKB/Swiss-Prot:P71071" /translation="MYIDITIDLKHYNGSVFDLRLSDYHPVKKVIDIAWQAQSVSMPP REGHWIRVVNKDKVFSGECKLSDCGITNGDRLEIL*" /label="yukD CDS" gene complement(2779912..2780151) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /label="yukD gene" CDS complement(2780221..2780514) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:11973144, 15576783, 22720735, 24798022, 24828531" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11973144, 15576783, 22720735, 24798022, 24828531; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small WGX100 secreted protein (ESX-dependent secretion)" /protein_id="NP_391069.2" /db_xref="EnsemblGenomes-Gn:BSU31910" /db_xref="EnsemblGenomes-Tr:CAB15179" /db_xref="GOA:C0SP85" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12378" /db_xref="UniProtKB/Swiss-Prot:C0SP85" /translation="MAGLIRVTPEELRAMAKQYGVESQEVLNQVDRLNRMISDLKSMW EGASSEAFADQYEQLKPSFIKMSDLLQDVNQQLDQTANTLESTDQDIANQIRG*" /label="yukE CDS" gene complement(2780221..2780514) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /label="yukE gene" downshifts complement(2780231) /Source="Nicolas_upshifts" /id="D1649" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="6.21938" /MaxDrop="7.50121" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=4155 /isTUend="FALSE" /label="downshifts" downshifts 2780508 /Source="Nicolas_upshifts" /id="D1650" /incds=0 /nref=1 /ntot=26 /MaxReadThrough="2.85718" /MaxDrop="3.33739" /score="43.0917981" /energy="-17.1" /TU="NA" /idTUdmin="U2487" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" S_feature complement(2780515..2780593) /Source="Nicolas_S_feature" /locus_tag="new_3276435_3276513_c" /HighExp="T-1.10H, T1.0H, T-0.40H, T1.30H, BI, T2.30H, T3.0H, T-2.40H, T2.0H, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1226" promotor_-35 2780556..2780563 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2780573..2780592) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2780574 /Source="Nicolas_upshifts" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2780578..2780595 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2780593) /Source="Nicolas_upshifts" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2780607..2780614) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2780652..2780657 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2780672..2780691 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2780684..2780790 /Source="Nicolas_S_feature" /locus_tag="new_3276604_3276710" /HighExp="S8, C30, S7, S6, Pyr, Glucon, B60, LoTm, C90, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="0.523, 0.76" /TUlongSig="NA" /TUlongPSig="NA" /label="S1227" upshifts 2780684 /Source="Nicolas_upshifts" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2780859..2780865 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2780879..2780898 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2780882 /Source="Nicolas_upshifts" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2780987..2780990 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-35" upshifts 2780999 /Source="Nicolas_upshifts" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="upshifts" promotor_-10 complement(2781002..2781021) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2781006..2781025 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-10" upshifts complement(2781024) /Source="Nicolas_upshifts" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2781035..2782303 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22797752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22797752; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AdeR-alanine)" /protein_id="NP_391070.2" /db_xref="EnsemblGenomes-Gn:BSU31920" /db_xref="EnsemblGenomes-Tr:CAB15180" /db_xref="GOA:P71073" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12379" /db_xref="UniProtKB/Swiss-Prot:P71073" /translation="MSKRNQARKVGRFMTMPNDPFKYSFDRLEDVADHISDVLRCPIT IEDVNHKLLAYSTHSDCTDPARTSTIIGRRVPEKVINKLWKDGTIPALLKTDQPIRVK QIDEVGLSNRVAISIWKNKQVLGFIWALEIQKTLSDEDLLTLQMAAKAVKNKLLKLQI RKTKNEERSQEFFWKMLTGHIHQEDDMADGFHKLGMAAPSEFSVMIIRINGELTEKIE QQLQYLQETTQQVYVLLATVDSNELIILTSPKTDHPFQDLKQFALSTQKQLKERYKIE DVSIAFGGIYNSISFVSRSYQEALSVLKTKERFAEETKHLFSFSELGIYQYLDVLNEK RKQAGHYNYSLSKLEQYDRDHQSNMVETLERFIEADSNVNTASKLLNIHVNTLNYRLK RISQIAEIDLKNVNQKFTIYLDIKLRHMDL*" /label="adeR CDS" gene 2781035..2782303 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /label="adeR gene" promotor_-35 complement(2781036..2781043) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2782363..2782382 /Source="Nicolas_upshift_promotors" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2782368 /Source="Nicolas_upshifts" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2782405..2783541 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /EC_number="1.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:488097, 8226620, 22720735, 22797752, 26202482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 488097, 8226620, 22720735, 22797752, 26202482; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-alanine dehydrogenase (NAD-dependent)" /protein_id="NP_391071.1" /db_xref="EnsemblGenomes-Gn:BSU31930" /db_xref="EnsemblGenomes-Tr:CAB15181" /db_xref="GOA:Q08352" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR007886" /db_xref="InterPro:IPR008141" /db_xref="InterPro:IPR008142" /db_xref="InterPro:IPR008143" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10468" /db_xref="UniProtKB/Swiss-Prot:Q08352" /translation="MIIGVPKEIKNNENRVALTPGGVSQLISNGHRVLVETGAGLGSG FENEAYESAGAEIIADPKQVWDAEMVMKVKEPLPEEYVYFRKGLVLFTYLHLAAEPEL AQALKDKGVTAIAYETVSEGRTLPLLTPMSEVAGRMAAQIGAQFLEKPKGGKGILLAG VPGVSRGKVTIIGGGVVGTNAAKMAVGLGADVTIIDLNADRLRQLDDIFGHQIKTLIS NPVNIADAVAEADLLICAVLIPGAKAPTLVTEEMVKQMKPGSVIVDVAIDQGGIVETV DHITTHDQPTYEKHGVVHYAVANMPGAVPRTSTIALTNVTVPYALQIANKGAVKALAD NTALRAGLNTANGHVTYEAVARDLGYEYVPAEKALQDESSVAGA*" /label="ald CDS" gene 2782405..2783541 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /label="ald gene" downshifts 2783541 /Source="Nicolas_upshifts" /id="D1651" /incds=0 /nref=42 /ntot=190 /MaxReadThrough="5.86626" /MaxDrop="4.4689" /score="41.2794059" /energy="-14.2" /TU="U2493" /idTUdmin="U2493" /TUdmin="-769" /isTUend="FALSE" /label="downshifts" promotor_-35 2783590..2783598 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2783608 /Source="Nicolas_upshifts" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2783610..2783628 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2783653..2784330 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391073.2" /db_xref="EnsemblGenomes-Gn:BSU31945" /db_xref="EnsemblGenomes-Tr:CAB15183" /db_xref="InterPro:IPR019268" /db_xref="SubtiList:BG12380" /db_xref="UniProtKB/Swiss-Prot:C0SPB1" /translation="MAVQQYGVLKGIVLDMKRETDDDSPHFQVKMLGEENTYYRCAIN VMSSSEESEVLYLADDQFDSGSITILPNMPYGYTRINEANREVALDYVRGNLFDPREM KPLPHEITGPDNDLNDFIETYMKKAQDEKTPVYIFGSKFGPEQAADKIFGFTPTNGMH NIHMNQGNAMDTRWKKDNGSWHDGGILIQFADQWAAVFLAFLSQSWCTDENGNPVRDC DHTQTSA*" /label="yukJ CDS" gene 2783653..2784330 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /label="yukJ gene" downshifts 2784314 /Source="Nicolas_upshifts" /id="D1652" /incds=0 /nref=37 /ntot=185 /MaxReadThrough="3.39608" /MaxDrop="5.40829" /score="9.49891506" /energy="-12" /TU="U2494" /idTUdmin="U2493" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(2784374..2784583) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11112781, 20845982, 21890635, 24975514, 28880538; Product type r: regulator" /codon_start=1 /transl_table=11 /product="stimulator of DhbF tyrosine adenylation activity" /protein_id="YP_003097779.1" /db_xref="EnsemblGenomes-Gn:BSU31959" /db_xref="EnsemblGenomes-Tr:CAX52685" /db_xref="InterPro:IPR005153" /db_xref="UniProtKB/Swiss-Prot:C0H3Q6" /translation="MANPFENADGTYLVLVNEEGQYSLWPGFIDVPSGWTVVHEQKGR EACLDYIQSHWSDMRPNSLKTVENV*" /label="mbtH CDS" gene complement(2784374..2784583) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /label="mbtH gene" downshifts complement(2784386) /Source="Nicolas_upshifts" /id="D1653" /incds=0 /nref=106 /ntot=174 /MaxReadThrough="1.39981" /MaxDrop="6.23998" /score="17.380299" /energy="-12" /TU="NA" /idTUdmin="U2496" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2784599..2791735) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /EC_number="2.7.7.-" /EC_number="5.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11112781, 12354229, 16672620, 18957859, 26284661, 27731335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11112781, 12354229, 16672620, 18957859, 26284661, 27731335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="siderophore 2,3-dihydroxybenzoate-glycine-threonine trimeric ester bacillibactin synthetase" /protein_id="NP_391076.3" /db_xref="EnsemblGenomes-Gn:BSU31960" /db_xref="EnsemblGenomes-Tr:CAB15186" /db_xref="GOA:P45745" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020802" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11243" /db_xref="UniProtKB/Swiss-Prot:P45745" /translation="MPDTKDLQYSLTGAQTGIWFAQQLDPDNPIYNTAEYIEINGPVN IALFEEALRHVIKEAESLHVRFGENMDGPWQMINPSPDVQLHVIDVSSEPDPEKTALN WMKADLAKPVDLGYAPLFNEALFIAGPDRFFWYQRIHHIAIDGFGFSLIAQRVASTYT ALIKGQTAKSRSFGSLQAILEEDTDYRGSEQYEKDRQFWLDRFADAPEVVSLADRAPR TSNSFLRHTAYLPPSDVNALKEAARYFSGSWHEVMIAVSAVYVHRMTGSEDVVLGLPM MGRIGSASLNVPAMVMNLLPLRLTVSSSMSFSELIQQISREIRSIRRHHKYRHEELRR DLKLIGENHRLFGPQINLMPFDYGLDFAGVRGTTHNLSAGPVDDLSINVYDRTDGSGL RIDVDANPEVYSESDIKLHQQRILQLLQTASAGEDMLIGQMELLLPEEKEKVISKWNE TAKSEKLVSLQDMFEKQAVLTPERIALMCDDIQVNYRKLNEEANRLARLLIEKGIGPE QFVALALPRSPEMVASMLGVLKTGAAYLPLDPEFPADRISYMLEDAKPSCIITTEEIA ASLPDDLAVPELVLDQAVTQEIIKRYSPENQDVSVSLDHPAYIIYTSGSTGRPKGVVV TQKSLSNFLLSMQEAFSLGEEDRLLAVTTVAFDISALELYLPLISGAQIVIAKKETIR EPQALAQMIENFDINIMQATPTLWHALVTSEPEKLRGLRVLVGGEALPSGLLQELQDL HCSVTNLYGPTETTIWSAAAFLEEGLKGVPPIGKPIWNTQVYVLDNGLQPVPPGVVGE LYIAGTGLARGYFHRPDLTAERFVADPYGPPGTRMYRTGDQARWRADGSLDYIGRADH QIKIRGFRIELGEIDAVLANHPHIEQAAVVVREDQPGDKRLAAYVVADAAIDTAELRR YMGASLPDYMVPSAFVEMDELPLTPNGKLDRKALPAPDFSTSVSDRAPRTPQEEILCD LFAEVLGLARVGIDDSFFELGGHSLLAARLMSRIREVMGAELGIAKLFDEPTVAGLAA HLDLAQSACPALQRAERPEKIPLSFAQRRLWFLHCLEGPSPTYNIPVAVRLSGELDQG LLKAALYDLVCRHESLRTIFPESQGTSYQHILDADRACPELHVTEIAEKELSDRLAEA VRYSFDLAAEPAFRAELFVIGPDEYVLLLLVHHIVGDGWSLTPLTRDLGTAYAARCHG RSPEWAPLAVQYADYALWQQELLGNEDDPNSLIAGQLAFWKETLKNLPDQLELPTDYS RPAEPSHDGDTIHFRIEPEFHKRLQELARANRVSLFMVLQSGLAALLTRLGAGTDIPI GSPIAGRNDDALGDLVGLFINTLVLRTDTSGDPSFRELLDRVREVNLAAYDNQDLPFE RLVEVLNPARSRATHPLFQIMLAFQNTPDAELHLPDMESSLRINSVGSAKFDLTLEIS EDRLADGTPNGMEGLLEYSTDLFKRETAQALADRLMRLLEAAESDPDEQIGNLDILAP EEHSSMVTDWQSVSEKIPHACLPEQFEKQAALRPDAIAVVYENQELSYAELNERANRL ARMMISEGVGPEQFVALALPRSLEMAVGLLAVLKAGAAYLPLDPDYPADRIAFMLKDA QPAFIMTNTKAANHIPPVENVPKIVLDDPELAEKLNTYPAGNPKNKDRTQPLSPLNTA YVIYTSGSTGVPKGVMIPHQNVTRLFAATEHWFRFSSGDIWTMFHSYAFDFSVWEIWG PLLHGGRLVIVPHHVSRSPEAFLRLLVKEGVTVLNQTPSAFYQFMQAEREQPDLGQAL SLRYVIFGGEALELSRLEDWYNRHPENRPQLINMYGITETTVHVSYIELDRSMAALRA NSLIGCGIPDLGVYVLDERLQPVPPGVAGELYVSGAGLARGYLGRPGLTSERFIADPF GPPGTRMYRTGDVARLRADGSLDYVGRADHQVKIRGFRIELGEIEAALVQHPQLEDAA VIVREDQPGDKRLAAYVIPSEETFDTAELRRYAAERLPDYMVPAAFVTMKELPLTPNG KLDRKALPAPDFAAAVTGRGPRTPQEEILCDLFMEVLHLPRVGIDDRFFDLGGHSLLA VQLMSRIREALGVELSIGNLFEAPTVAGLAERLEMGSSQSALDVLLPLRTSGDKPPLF CVHPAGGLSWCYAGLMTNIGTDYPIYGLQARGIGQREELPKTLDDMAADYIKQIRTVQ PKGPYHLLGWSLGGNVVQAMATQLQNQGEEVSLLVMLDAYPNHFLPIKEAPDDEEALI ALLALGGYDPDSLGEKPLDFEAAIEILRRDGSALASLDETVILNLKNTYVNSVGILGS YKPKTFRGNVLFFRSTIIPEWFDPIEPDSWKPYINGQIEQIDIDCRHKDLCQPEPLAQ IGKVLAVKLEELNK*" /label="dhbF CDS" gene complement(2784599..2791735) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /label="dhbF gene" CDS complement(2791755..2792693) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /EC_number="3.3.2.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismatase (siderophore specific)" /protein_id="NP_391077.1" /db_xref="EnsemblGenomes-Gn:BSU31970" /db_xref="EnsemblGenomes-Tr:CAB15187" /db_xref="GOA:P45743" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11241" /db_xref="UniProtKB/Swiss-Prot:P45743" /translation="MAIPAIQPYQMPTASDMPQNKVSWVPDPNRAVLLIHDMQNYFVD AFTAGASPVTELSANIRKLKNQCVQLGIPVVYTAQPGSQNPDDRALLTDFWGPGLNSG PYEEKIITELAPEDDDLVLTKWRYSAFKRTNLLEMMRKEGRDQLIITGIYAHIGCLVT ACEAFMEDIKAFFVGDAVADFSLEKHQMALEYAAGRCAFTVMTDSLLDQLQNAPADVQ KTSANTGKKNVFTCENIRKQIAELLQETPEDITDQEDLLDRGLDSVRIMTLVEQWRRE GAEVTFVELAERPTIEEWQKLLTTRSQQVLPNADYL*" /label="dhbB CDS" gene complement(2791755..2792693) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /label="dhbB gene" CDS complement(2792721..2794340) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /EC_number="2.7.7.58" /EC_number="6.3.2.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydroxybenzoate-AMP ligase" /protein_id="NP_391078.1" /db_xref="EnsemblGenomes-Gn:BSU31980" /db_xref="EnsemblGenomes-Tr:CAB15188" /db_xref="GOA:P40871" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR011963" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:1MD9" /db_xref="PDB:1MDB" /db_xref="PDB:1MDF" /db_xref="SubtiList:BG11020" /db_xref="UniProtKB/Swiss-Prot:P40871" /translation="MLKGFTPWPDELAETYRKNGCWAGETFGDLLRDRAAKYGDRIAI TCGNTHWSYRELDTRADRLAAGFQKLGIQQMDRVVVQLPNIKEFFEVIFALFRLGALP VFALPSHRSSEITYFCEFAEAAAYIIPDAYSGFDYRSLARQVQSKLPTLKNIIVAGEA EEFLPLEDLHAEPVKLPEVKSSDVAFLQLSGGSTGLSKLIPRTHDDYIYSLKRSVEVC WLDHSTVYLAALPMAHNYPLSSPGVLGVLYAGGRVVLSPSPSPDDAFPLIEREKVTIT ALVPPLAMVWMDAASSRRDDLSSLQVLQVGGAKFSAEAARRVKAVFGCTLQQVFGMAE GLVNYTRLDDPEEIIVNTQGKPMSPYDEMRVWDDHDRDVKPGETGHLLTRGPYTIRGY YKAEEHNAASFTEDGFYRTGDIVRLTRDGYIVVEGRAKDQINRGGEKVAAEEVENHLL AHPAVHDAAMVSMPDQFLGERSCVFIIPRDEAPKAAELKAFLRERGLAAYKIPDRVEF VESFPQTGVGKVSKKALREAISEKLLAGFKK*" /label="dhbE CDS" gene complement(2792721..2794340) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /label="dhbE gene" CDS complement(2794369..2795565) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /EC_number="5.4.4.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12354229, 16672620, 19777807, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismate synthase (siderophore-specific)" /protein_id="NP_391079.2" /db_xref="EnsemblGenomes-Gn:BSU31990" /db_xref="EnsemblGenomes-Tr:CAB15189" /db_xref="GOA:P45744" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="SubtiList:BG11242" /db_xref="UniProtKB/Swiss-Prot:P45744" /translation="MLDQNVITETKAEHLLHEYQPGAFFLASPHRVLLAKGICEIVPE ADGQNQMETLSGRIAEALRQAKQSGQSRPLVVGAVPFDQVKAARLVVPEEVRWSGPLQ FDHEEKEQQAGHTYHIKPVPEPEDYKNGVEQGLARIADGTLSKIVLSRSLHLTSPEPI QTDELLRHLAQHNSHGYTFAADVSSQEETSPRRTLLGASPELLVSRMGTQVVSNPLAG SRPRSNDPVEDQRRAAELLSSAKDLHEHAVVADAVAAALRPFCRTLEVPEKPSLIKTE TMWHLSSVIKGELSDPSVTALELAAALHPTPAVCGTPTDLAREAILSIEPFDRGFFTG MVGWCDDAGDGEWIVTIRCAEAEERSLRLYAGAGVVAGSKPEDELQETSAKFRTMLRA MGVDHI*" /label="dhbC CDS" gene complement(2794369..2795565) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /label="dhbC gene" promotor_-35 2795413..2795420 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2795435..2795454 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2795442 /Source="Nicolas_upshifts" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2795591..2796376) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /EC_number="1.3.1.28" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase" /protein_id="NP_391080.2" /db_xref="EnsemblGenomes-Gn:BSU32000" /db_xref="EnsemblGenomes-Tr:CAB15190" /db_xref="GOA:P39071" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR003560" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11019" /db_xref="UniProtKB/Swiss-Prot:P39071" /translation="MNAKGIEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEK LEKVVSSLKAEGRHAEAFPADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIH SLSDEEWEATFSVNSTGVFNASRSVSKYMMDRRSGSIVTVGSNAAGVPRTSMAAYASS KAAAVMFTKCLGLELAEYNIRCNIVSPGSTETDMQWSLWADENGAEQVIKGSLETFKT GIPLKKLAKPSDIADAVLFLVSGQAGHITMHNLCVDGGATLGV*" /label="dhbA CDS" gene complement(2795591..2796376) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /label="dhbA gene" S_feature complement(2796377..2796486) /Source="Nicolas_S_feature" /locus_tag="new_3292297_3292406_c" /HighExp="HiOs, GM 15, B60, nit, GM 10, GM 25, B36, GM 60, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1228" promotor_-10 complement(2796481..2796500) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2796486) /Source="Nicolas_upshifts" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2796488..2796569) /Source="Nicolas_S_feature" /locus_tag="new_3292408_3292489_c" /HighExp="HiOs, B60, nit, B36, GM 45, GM 10, BI, GM 15, GM 25, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1229" promotor_-35 complement(2796514..2796521) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2796570..2797439) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16889643, 19673474, 26284661, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillibactin trilactone hydrolase" /protein_id="NP_391081.2" /db_xref="EnsemblGenomes-Gn:BSU32010" /db_xref="EnsemblGenomes-Tr:CAB15191" /db_xref="GOA:O32102" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13974" /db_xref="UniProtKB/Swiss-Prot:O32102" /translation="MKEQTTDRTNGGTSNAFTIPGTEVRMMSSRNENRTYHIFISKPS TPPPPAGYPVIYLLDANSVFGTMTEAVRIQGRRPEKTGVIPAVIVGIGYETAEPFSSA RHRDFTMPTAQSKLPERPDGREWPEHGGAEGFFRFIEEDLKPEIERDYQIDKKRQTIF GHSLGGLFVLQVLLTKPDAFQTYIAGSPSIHWNKPFILKKTDHFVSLTKKNNQPINIL LAAGELEQHHKSRMNDNARELYERLAVLSEQGIRAEFCEFSGEGHISVLPVLVSRALR FALHPDGPHLSMG*" /label="besA CDS" gene complement(2796570..2797439) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /label="besA gene" S_feature complement(2797440..2797520) /Source="Nicolas_S_feature" /locus_tag="new_3293360_3293440_c" /HighExp="HiOs, B60, nit, GM 15, BI, B36, LoTm, T-5.40H, Lbexp, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1230" promotor_-10 complement(2797504..2797523) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2797520) /Source="Nicolas_upshifts" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2797537..2797544) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2797653..2798249) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /EC_number="1.7.3.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11598126, 16341843, 21190336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin containing enzyme subunit" /protein_id="NP_391082.1" /db_xref="EnsemblGenomes-Gn:BSU32020" /db_xref="EnsemblGenomes-Tr:CAB15192" /db_xref="GOA:O32103" /db_xref="InterPro:IPR000572" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13973" /db_xref="UniProtKB/Swiss-Prot:O32103" /translation="MYFGKTRQSDQSGRVPPNQNVTTSFPVLHTGDVPYYEDMTKWNL QVYGLVDHPMLLSFEDVKAFPRYESKNDIHCVTGWSRLDNVWQGVRACDIAEKAGVKE EAGYVILHAEEGWTTNLPLDDFLAETSLLAYAHNGEPLTPEHGFPLRGVFPHLYFWKS AKWLRGIQFTKENHPGFWERNGYHMRGDPWQNQRFTWD*" /label="yuiH CDS" gene complement(2797653..2798249) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /label="yuiH gene" S_feature complement(2798250..2798334) /Source="Nicolas_S_feature" /locus_tag="new_3294170_3294254_c" /HighExp="H2O2, Paraq, Cold, dia15, G135, B36, G180, B60, LoTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.204" /TUlongSig="NA" /TUlongPSig="NA" /label="S1231" promotor_-35 2798285..2798292 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2798302 /Source="Nicolas_upshifts" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2798307..2798326 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2798328..2798342) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2798334) /Source="Nicolas_upshifts" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2798350..2798354) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2798350..2798952 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717296, 15849754, 16850406, 24816803; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative biotin transporter" /protein_id="NP_391083.1" /db_xref="EnsemblGenomes-Gn:BSU32030" /db_xref="EnsemblGenomes-Tr:CAB15193" /db_xref="GOA:O32104" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13972" /db_xref="UniProtKB/Swiss-Prot:O32104" /translation="MKQRKLRAGDMALIGMFAALMAVGANITSVAPFLQVAGIPLSMQ PFFCLLAALLLGSKRAAIAMIVYALVGLAGAPVFAQFSAGFAPFAGKSGGFIISYIPA AFAAGWFLERNIQPSKIRFLIASLIGTAIMYLIGTTYMYLALKLWIHTPVSYGTAWGF MIWFMVKDTALAVILSFIAPAIYRSIHKATGFNRNHISST*" /label="bioYB CDS" gene 2798350..2798952 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /label="bioYB gene" downshifts 2798938 /Source="Nicolas_upshifts" /id="D1654" /incds=0 /nref=145 /ntot=206 /MaxReadThrough="3.24182" /MaxDrop="6.72885" /score="12.6395055" /energy="-6.3" /TU="U2498" /idTUdmin="U2498" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" CDS complement(2799022..2800350) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15135544, 15849754, 16850406, 23504016; Product type t : transporter" /codon_start=1 /transl_table=11 /product="histidine / basic amino acid transporter" /protein_id="NP_391084.1" /db_xref="EnsemblGenomes-Gn:BSU32040" /db_xref="EnsemblGenomes-Tr:CAB15194" /db_xref="GOA:O32105" /db_xref="InterPro:IPR018461" /db_xref="InterPro:IPR032813" /db_xref="SubtiList:BG13971" /db_xref="UniProtKB/Swiss-Prot:O32105" /translation="MNAVVIAVLLMLVLSLLRVNIVIALIIGALAGGLTGGLGLGETV KAFTDGLGGNATVAVSYAMLGAFAAALTKTGLPDAMVEASVKLIGNKEDSRKKALSKV LIVLIILIVSCFSQNVVPVHIAFIPVLIPPLLKIFNELEMDRRLIACVITFGLTAPYI LLPVGFGQIFQGMLKDNMADAGLNVPLADIPYALIIPVAGMVVGLILSVIVYRKPKQY ETKDISGAEASPYTRKSIGIAVLAIVVSLGVQLYLSQTLGVEGMIMGALAGLIVLFVS GVMKRDEADSLITDGMVLMAFIGFVMLVAAGFSNVLTKTGDVESLVKTSAGFIGHSQS LGALLMLIVGLLITMGIGSSFATIPVITTIFVPLCMQLGFSPMATIAIIGAAAALGDA GSPASDSTLGPTSGLSADGQHHHIWDTCVPTFIFYNIPLVIFGWIAALVL*" /label="hisP CDS" gene complement(2799022..2800350) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /label="hisP gene" downshifts complement(2799038) /Source="Nicolas_upshifts" /id="D1655" /incds=0 /nref=14 /ntot=114 /MaxReadThrough="4.26298" /MaxDrop="4.37949" /score="18.6861113" /energy="-15.4" /TU="U2500" /idTUdmin="U2500" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2800404..2800423) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2800407) /Source="Nicolas_upshifts" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2800438..2800445) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2800497..2801999) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /EC_number="3.4.11.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8057849, 9864319, 10449417, 26936797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytosol aminopeptidase" /protein_id="NP_391085.1" /db_xref="EnsemblGenomes-Gn:BSU32050" /db_xref="EnsemblGenomes-Tr:CAB15195" /db_xref="GOA:O32106" /db_xref="InterPro:IPR000819" /db_xref="InterPro:IPR008283" /db_xref="InterPro:IPR011356" /db_xref="InterPro:IPR023042" /db_xref="SubtiList:BG13970" /db_xref="UniProtKB/Swiss-Prot:O32106" /translation="MFYAVQQSEHTETLVVGLFQKSQLTGKALEIDEMLEGHLTQLLK EGDVSAKPNQVSKVFPPSSAGMKRIYFVGLGREANYSFEQAKERFAHVFQAIHKDRKQ ETAVLLDTFISEDVPPADAAHALAESCLLASYEVQDYKHKSNEPDKQIEAVYVVTDED TQEVQAGLRVGQAYGQGTNSARTLVNMPGNMLTATDLASYAEELAAKYDFECEILEKS EMEELGMGGILAVNQGSTEPPKMIVLKYQGKKEWEDVVGLVGKGITFDTGGYSIKTKS GIVGMKSDMGGAAAVLGAMETIGELRPEQNVLCVIPSTDNMISGGAMKPDDVIVSLSG KTIEILNTDAEGRLVLADGITYAKQHGASVLVDVATLTGGVVVALGTETTGAMTNDQS FYQQVADAAQECGEAIWQLPITEKDKKRVKSSQMADLSNSPGREGHAIMAGTFLGEFA ESTPWVHLDIAGTATANKATCFGPAGATGVMARTLATLAERFTLEEDKNE*" /label="pepA CDS" gene complement(2800497..2801999) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /label="pepA gene" downshifts complement(2800512) /Source="Nicolas_upshifts" /id="D1656" /incds=0 /nref=149 /ntot=220 /MaxReadThrough="4.44151" /MaxDrop="5.59726" /score="31.6277104" /energy="-16" /TU="NA" /idTUdmin="U2503" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 2801564..2801578 /Source="Nicolas_upshift_promotors" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2801580 /Source="Nicolas_upshifts" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2802000..2802074) /Source="Nicolas_S_feature" /locus_tag="new_3297920_3297994_c" /HighExp="M40t90, Lbtran, LBGtran, Lbstat, C90, M0t90, T1.0H, LoTm, M40t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1232" promotor_-35 2802022..2802029 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2802040..2802059 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2802042..2802156 /Source="Nicolas_S_feature" /locus_tag="new_3297962_3298076" /HighExp="Etha, Cold, Gly, Sw, LoTm, BC, B60, C90, dia5, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1233" upshifts 2802042 /Source="Nicolas_upshifts" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2802069..2802088) /Source="Nicolas_upshift_promotors" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2802079) /Source="Nicolas_upshifts" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="upshifts" CDS 2802157..2802633 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391086.1" /db_xref="EnsemblGenomes-Gn:BSU32060" /db_xref="EnsemblGenomes-Tr:CAB15196" /db_xref="GOA:O32107" /db_xref="InterPro:IPR003832" /db_xref="SubtiList:BG13969" /db_xref="UniProtKB/Swiss-Prot:O32107" /translation="MELLTNFPLLSSLAAIIFAQVIKVPIQFIVSRKLDWSLVTSTGG MPSSHSAAVTALSTGVALEHGLDSSLFAVSAIFAVITMFDATGVRRHAGEQATVINKL VIDFNRFVNEAKDFPKAAEKEKQKKLKELLGHQPIEVFFGGLTGILLTLVLAYFFM*" /label="yuiD CDS" gene 2802157..2802633 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /label="yuiD gene" downshifts 2802582 /Source="Nicolas_upshifts" /id="D1657" /incds=0 /nref=18 /ntot=174 /MaxReadThrough="3.22946" /MaxDrop="3.90704" /score="10.9647804" /energy="-11.6" /TU="U2502" /idTUdmin="U2502" /TUdmin="-208" /isTUend="FALSE" /label="downshifts" CDS complement(2802664..2803320) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /experiment="publication(s) with functional evidences, PMID:26163297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26163297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stationary phase survival protein" /protein_id="NP_391087.1" /db_xref="EnsemblGenomes-Gn:BSU32070" /db_xref="EnsemblGenomes-Tr:CAB15197" /db_xref="GOA:O32108" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR036908" /db_xref="PDB:4WJT" /db_xref="PDB:4WLI" /db_xref="PDB:4WLK" /db_xref="SubtiList:BG13968" /db_xref="UniProtKB/Swiss-Prot:O32108" /translation="MMLNMIRRLLMTCLFLLAFGTTFLSVSGIEAKDLSKWVQEHQEK HLKHAGLRLKALQQKQTQTTSAAEDKTKPLEEAFDWDEYPVQRVTATGYTAGAESTGK NPGDPLYGLTYSGVKVKRDLYSTVAADPSVFPIGTILFIPNYGLGVVADTGSAIKGNR LDLYFETVKDVYNEWGKKTLDVYVIKKGTGKITEDELEKLNETKSLQVFRNQYKTVKE *" /label="spsC CDS" gene complement(2802664..2803320) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /label="spsC gene" downshifts complement(2802692) /Source="Nicolas_upshifts" /id="D1658" /incds=0 /nref=178 /ntot=253 /MaxReadThrough="0.714039999999999" /MaxDrop="6.31907" /score="33.0538307" /energy="-12.6" /TU="NA" /idTUdmin="U2505" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2802968..2802977 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2802991..2803010 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2803008 /Source="Nicolas_upshifts" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="upshifts" S_feature 2803010..2803456 /Source="Nicolas_S_feature" /locus_tag="new_3298930_3299376" /HighExp="S6, S8, S7, BT, B36, G/S, S5, Pyr, Cold, B60" /AntisenseName="yuiC" /AntisenseCor="0.52395204592174105" /AntisenseRegPval="-19.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1234" upshifts complement(2803334) /Source="Nicolas_upshifts" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2803336..2803347) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2803362..2803368) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2803413 /Source="Nicolas_upshifts" /id="D1659" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="7.61734" /MaxDrop="4.9382" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin="-323" /isTUend="FALSE" /label="downshifts" CDS complement(2803424..2803744) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391088.1" /db_xref="EnsemblGenomes-Gn:BSU32080" /db_xref="EnsemblGenomes-Tr:CAB15198" /db_xref="GOA:O32109" /db_xref="InterPro:IPR025917" /db_xref="SubtiList:BG13967" /db_xref="UniProtKB/Swiss-Prot:O32109" /translation="MISLPVVIISIVLFFVLFFGIGFLLNMLLRMSWIMAVIYPIVCL FIISKEKLISYVQSPGESFASLFHRVLSLAAADVLILVSGLAGAIVSGIAINMLRKRG YQMF*" /label="yuiB CDS" gene complement(2803424..2803744) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /label="yuiB gene" downshifts complement(2803438) /Source="Nicolas_upshifts" /id="D1660" /incds=0 /nref=151 /ntot=218 /MaxReadThrough="4.24535" /MaxDrop="5.6597" /score="13.4559443" /energy="-7.6" /TU="U2507,U2508" /idTUdmin="U2510" /TUdmin=660 /isTUend="FALSE" /label="downshifts" S_feature 2803458..2803668 /Source="Nicolas_S_feature" /locus_tag="new_3299378_3299588" /HighExp="S8, S6, S7, BT, Cold, Gly, H2O2, G/S, C30, G180" /AntisenseName="yuiB" /AntisenseCor="-0.11290507783715401" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1235" promotor_no_box 2803610..2803710 /Source="Nicolas_upshift_promotors" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 2803670..2803779 /Source="Nicolas_S_feature" /locus_tag="new_3299590_3299699" /HighExp="S8, S6, BT, S7, Sw, Gly, G180, BC, Diami, H2O2" /AntisenseName="yuiB" /AntisenseCor="-7.7565560595235006E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.03, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1236" upshifts 2803670 /Source="Nicolas_upshifts" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="upshifts" downshifts 2803736 /Source="Nicolas_upshifts" /id="D1661" /incds=0 /nref=10 /ntot=28 /MaxReadThrough="3.79664" /MaxDrop="6.06021" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2803763..2803782) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2803768) /Source="Nicolas_upshifts" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="upshifts" S_feature 2803781..2804332 /Source="Nicolas_S_feature" /locus_tag="new_3299701_3300252" /HighExp="S6, S8, S7, Cold, H2O2, BC, Sw, Pyr, BT, C30" /AntisenseName="yuiA" /AntisenseCor="5.87811391089679E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1237" promotor_-35 complement(2803797..2803804) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2803798..2803941) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391089.1" /db_xref="EnsemblGenomes-Gn:BSU32090" /db_xref="EnsemblGenomes-Tr:CAB15199" /db_xref="InterPro:IPR035272" /db_xref="InterPro:IPR036410" /db_xref="SubtiList:BG12389" /db_xref="UniProtKB/Swiss-Prot:O32110" /translation="MKTATTTASHACPFCSGKGYFQLILGGSETCPSCQGTGKDSHSF SSR*" /label="yuiA CDS" gene complement(2803798..2803941) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /label="yuiA gene" promotor_-10 complement(2803965..2803984) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2803986) /Source="Nicolas_upshifts" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2804000..2804003) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2804114..2805334) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 17015645, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-disulfide oxidoreductase" /protein_id="NP_391090.1" /db_xref="EnsemblGenomes-Gn:BSU32100" /db_xref="EnsemblGenomes-Tr:CAB15200" /db_xref="GOA:O05267" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12390" /db_xref="UniProtKB/Swiss-Prot:O05267" /translation="MALNKPKIVILGAGYGGLMTVTRLTKYVGPNDADITLVNKHNYH YETTWMHEASAGTLHHDRCRYQIKDVINQSRVNFVQDTVKAIKIDEKKVVLANGELQY DYLVIGLGAVPETFGIKGLKEYAFPIANINTSRLLREHIELQFATYNTEAEKRPDRLT IVVGGAGFTGIEFLGELAARVPELCKEYDVDRSLVRIICVEAAPTVLPGFDPELVDYA VHYLEENGVEFKIGTAVQECTPEGVRVGKKDEEPEQIKSQTVVWAAGVRGHPIVEEAG FENMRGRVKVNPDLRAPGHDNVFILGDSSLFMNEDTERPYPPTAQIAMQQGITVAKNL GRLIKGGELEEFKPDIKGTVASLGEHNAVGVVYGRKLKGTPASFMKKVIDNRSLFMIG GLGLTLKKGKFKFF*" /label="yumB CDS" gene complement(2804114..2805334) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /label="yumB gene" downshifts complement(2804142) /Source="Nicolas_upshifts" /id="D1662" /incds=0 /nref=15 /ntot=123 /MaxReadThrough="3.19525" /MaxDrop="3.6794" /score="23.523765" /energy="-8.9" /TU="U2510" /idTUdmin="U2509" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2805335..2805462) /Source="Nicolas_S_feature" /locus_tag="new_3301255_3301382_c" /HighExp="Salt, S4, Etha, S5, S3, S7, S6, LoTm, B36, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.752, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1238" upshifts complement(2805462) /Source="Nicolas_upshifts" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2805464..2805528) /Source="Nicolas_S_feature" /locus_tag="new_3301384_3301448_c" /HighExp="Salt, Etha, Heat, BMM, BC, H2O2, Paraq, C30, Sw, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1239" promotor_-10 complement(2805464..2805482) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2805498..2805503) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2805519..2805538) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2805527) /Source="Nicolas_upshifts" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2805553..2805560) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2805602..2805609 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2805621..2805640 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2805621 /Source="Nicolas_upshifts" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="upshifts" CDS 2805666..2806664 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /EC_number="1.18.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15252706, 22938038, 26507228, 26965753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 22938038, 26507228, 26965753; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferredoxin-NADP+ reductase (flavodoxin)" /protein_id="NP_391091.2" /db_xref="EnsemblGenomes-Gn:BSU32110" /db_xref="EnsemblGenomes-Tr:CAB15201" /db_xref="GOA:O05268" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="PDB:3LZW" /db_xref="PDB:3LZX" /db_xref="SubtiList:BG12391" /db_xref="UniProtKB/Swiss-Prot:O05268" /translation="MREDTKVYDITIIGGGPVGLFTAFYGGMRQASVKIIESLPQLGG QLSALYPEKYIYDVAGFPKIRAQELINNLKEQMAKFDQTICLEQAVESVEKQADGVFK LVTNEETHYSKTVIITAGNGAFKPRKLELENAEQYEGKNLHYFVDDLQKFAGRRVAIL GGGDSAVDWALMLEPIAKEVSIIHRRDKFRAHEHSVENLHASKVNVLTPFVPAELIGE DKIEQLVLEEVKGDRKEILEIDDLIVNYGFVSSLGPIKNWGLDIEKNSIVVKSTMETN IEGFFAAGDICTYEGKVNLIASGFGEAPTAVNNAKAYMDPKARVQPLHSTSLFENK*" /label="trxBB CDS" gene 2805666..2806664 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /label="trxBB gene" promotor_-10 complement(2805689..2805707) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2805704) /Source="Nicolas_upshifts" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2805724..2805729) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2806640 /Source="Nicolas_upshifts" /id="D1663" /incds=0 /nref=162 /ntot=262 /MaxReadThrough="0.70088" /MaxDrop="7.47867" /score="21.6819221" /energy="-12.8" /TU="U2511" /idTUdmin="U2511" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2806703..2806843) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein or unknown function" /protein_id="NP_391092.1" /db_xref="EnsemblGenomes-Gn:BSU32120" /db_xref="EnsemblGenomes-Tr:CAB15202" /db_xref="GOA:O32111" /db_xref="SubtiList:BG14056" /db_xref="UniProtKB/Swiss-Prot:O32111" /translation="MAQNEEKTPKSQKIQDRIIMAMIWVVAALVIALVVGTALNYINI FK*" /label="yuzG CDS" gene complement(2806703..2806843) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /label="yuzG gene" downshifts complement(2806715) /Source="Nicolas_upshifts" /id="D1664" /incds=0 /nref=61 /ntot=234 /MaxReadThrough="1.27572" /MaxDrop="5.65243" /score="32.0354025" /energy="-12.8" /TU="NA" /idTUdmin="U2515" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(2806844..2806973) /Source="Nicolas_S_feature" /locus_tag="new_3302764_3302893_c" /HighExp="dia15, Salt, Cold, Diami, H2O2, Etha, GM 15, dia5, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.36371900000000001" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1240" promotor_-10 complement(2806954..2806973) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2806973) /Source="Nicolas_upshifts" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2806975..2807222) /Source="Nicolas_S_feature" /locus_tag="new_3302895_3303142_c" /HighExp="S8, S5, S6, S7, S4, ferm, nit, C30, Pyr, T5.0H" /AntisenseName="guaC" /AntisenseCor="-0.291283195124732" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1241" promotor_-35 complement(2806987..2806993) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2807030..2807037 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2807051..2807070 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2807059 /Source="Nicolas_upshifts" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="upshifts" CDS 2807122..2808102 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /EC_number="1.7.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 11591660, 6408059" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 11591660, 6408059; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP reductase (NADP-dependent)" /protein_id="NP_391093.2" /db_xref="EnsemblGenomes-Gn:BSU32130" /db_xref="EnsemblGenomes-Tr:CAB15203" /db_xref="GOA:O05269" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005994" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG12392" /db_xref="UniProtKB/Swiss-Prot:O05269" /translation="MENVFDYEDIQLIPAKCIVNSRSECDTSVRLGGHTFKLPVVPAN MQTIIDEKLAISLAENGYFYVMHRFEPETRIDFIKDMNARGLFSSISVGVKDEEYEFV RQLAEENLTPEYVTIDIAHGHSNAVIEMIQHLKKHLPDSFVIAGNVGTPEAVRELENA GADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKPIIADGGIRTHGDIAK SIRFGATMVMIGSLFAGHEESPGQTIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMHV AHKGSIKDTLIEMEQDLQSSISYAGGTKLNAIRNVDYVIVKNSIFNGDKY*" /label="guaC CDS" gene 2807122..2808102 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /label="guaC gene" upshifts complement(2807223) /Source="Nicolas_upshifts" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2807227..2807238) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2807252..2807258) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2808070 /Source="Nicolas_upshifts" /id="D1665" /incds=0 /nref=91 /ntot=186 /MaxReadThrough="1.24882" /MaxDrop="7.43286" /score="-2.82053244" /energy="-16.2" /TU="NA" /idTUdmin="U2514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2808175) /Source="Nicolas_upshifts" /id="D1666" /incds=0 /nref=24 /ntot=212 /MaxReadThrough="1.15696" /MaxDrop="6.12198" /score="23.834956" /energy="-16.2" /TU="NA" /idTUdmin="U2517" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2808176..2808799) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16210326, 21633969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates paiA expression)" /protein_id="NP_391094.2" /db_xref="EnsemblGenomes-Gn:BSU32140" /db_xref="EnsemblGenomes-Tr:CAB15204" /db_xref="GOA:P21341" /db_xref="InterPro:IPR007396" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG10696" /db_xref="UniProtKB/Swiss-Prot:P21341" /translation="MYIPKYFKVTNAEEIWNFVQENSFGTVVTTEQGKPIATHLPLGF NKKDDHYYITGHFAYGNPQWRTFEACEDVLVMFQGPHAYISSSWYSRENVPTWNYQAV HMYGKASMLEKDELAEELTIMLEKYEKHRDNPVLWDKLSPKLLESELKGIVGFKIKVE DIQAAYKLSQNRNETDYMNVIEQLQNEENPNAKQMAELMEDKLKKQI*" /label="paiB CDS" gene complement(2808176..2808799) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /label="paiB gene" CDS complement(2808823..2809341) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /EC_number="2.3.1.57" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16210326, 17588214, 21633970, 26818562, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16210326, 17588214, 21633970, 26818562, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyamine N-acetyltransferase" /protein_id="NP_391095.1" /db_xref="EnsemblGenomes-Gn:BSU32150" /db_xref="EnsemblGenomes-Tr:CAB15205" /db_xref="GOA:P21340" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1TIQ" /db_xref="SubtiList:BG10695" /db_xref="UniProtKB/Swiss-Prot:P21340" /translation="MSVKMKKCSREDLQTLQQLSIETFNDTFKEQNSPENMKAYLESA FNTEQLEKELSNMSSQFFFIYFDHEIAGYVKVNIDDAQSEEMGAESLEIERIYIKNSF QKHGLGKHLLNKAIEIALERNKKNIWLGVWEKNENAIAFYKKMGFVQTGAHSFYMGDE EQTDLIMAKTLI*" /label="paiA CDS" gene complement(2808823..2809341) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /label="paiA gene" misc_feature complement(2809388..2809407) /Source="Nicolas_upshift_promotors" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2809400) /Source="Nicolas_upshifts" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2809402..2809510) /Source="Nicolas_S_feature" /locus_tag="new_3305322_3305430_c" /HighExp="LoTm, HiTm, G135, Salt, G180, Cold, LBGstat, T0.0H, B36, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1242" promotor_-10 complement(2809497..2809514) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2809508) /Source="Nicolas_upshifts" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2809529..2809536) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2809664) /Source="Nicolas_upshifts" /id="D1667" /incds=0 /nref=267 /ntot=269 /MaxReadThrough="1.56881" /MaxDrop="8.24828" /score="12.6937405" /energy="-18.7" /TU="NA" /idTUdmin="U2518" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2809679..2810041) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17698959, 19478995, 20097860, 25447545; Product type c: carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier chaperone involved in Fe-S cluster assembly" /protein_id="NP_391096.1" /db_xref="EnsemblGenomes-Gn:BSU32160" /db_xref="EnsemblGenomes-Tr:CAB15206" /db_xref="GOA:O32113" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR016092" /db_xref="InterPro:IPR017870" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG14049" /db_xref="UniProtKB/Swiss-Prot:O32113" /translation="MSNPVTITEAAALHIKDMMKEHEEENAFLRVGVKGGGCSGLSYG MGFEHEKSESDSVFDQHGITVLVDKESLDIMNGTVIDYKQSMLGGGFTIDNPNAIASC GCGSSFRTATNAGKPEEC*" /label="sufA CDS" gene complement(2809679..2810041) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /label="sufA gene" promotor_-10 complement(2810072..2810091) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2810082) /Source="Nicolas_upshifts" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2810105..2810112) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2810120..2810974) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /EC_number="5.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 14627808, 16723397, 19307721, 28873470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diaminopimelate epimerase" /protein_id="NP_391097.1" /db_xref="EnsemblGenomes-Gn:BSU32170" /db_xref="EnsemblGenomes-Tr:CAB15207" /db_xref="GOA:O32114" /db_xref="InterPro:IPR001653" /db_xref="InterPro:IPR018510" /db_xref="SubtiList:BG14048" /db_xref="UniProtKB/Swiss-Prot:O32114" /translation="MNSFRFTKMHGLGNSYIYVNQFEEQLPEEKLSEIAIQVSSVYTG IGSDGMILICPSDQAPVKMRIFNNDGSEGKNCGNGLRCVAKYAYEHKLVEETSFLIET LSGLVKAEVQVENGKVNVVTVDMGEPRLTKSELPMLDGGEEHTINETMAFGEVELTGT AVSMGNPHIVFPIADIEQAPLTTLGPVIEKDPRFPEGINVEFVETVNEQELHFRVWER GSGITQACGTGACAAAVASVLNGVSKRNQDITVHLAGGDLVINWKDNGHVMMTGPAET VCEGVYFL*" /label="dapF CDS" gene complement(2810120..2810974) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /label="dapF gene" promotor_-10 complement(2810690..2810709) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2810698) /Source="Nicolas_upshifts" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2810722..2810731) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2810996..2811015) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2811010) /Source="Nicolas_upshifts" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2811030..2811033) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2811097..2812311) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+(H+)/nucleoside cotransporter" /protein_id="NP_391098.1" /db_xref="EnsemblGenomes-Gn:BSU32180" /db_xref="EnsemblGenomes-Tr:CAB15208" /db_xref="GOA:O32115" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG14047" /db_xref="UniProtKB/Swiss-Prot:O32115" /translation="MNVLWGLLGAVAIIAIAFLFSEKKSNIKIRTVIVGLCTQVAFGY IVLKWEAGRAVFLWFSSRVQLLIDYANEGISFIFGPLLKVGDSPAFALSVLPVIIFFS ALIAVLYHLKIMQLVFRVIGGGLSKLLGTSKTESLAAAANIFVGQSESPLVIKPLIAG LTRSELFTIMTSGLSAVAGSTLFGYALLGIPIEYLLAASFMAAPAGLVFGKLIIPETE KTQTVKSDFKMDEGEGAANVIDAAAKGASTGLQIALNVGAMLLAFVALIAVVNGILGG AFGLFGLKGVTLESILGYVFSPIAFLIGVPWHEALQAGSYIGQKLVLNEFVAYSNFGS HIGEFSKKTATIISFALCGFANFSSIAIMLGTLGGLAPSRRSDIARLGLKAVLAGTLA NLLSAAIAGMFI*" /label="yutK CDS" gene complement(2811097..2812311) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /label="yutK gene" promotor_-35 2811646..2811652 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2811667..2811685 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2811674 /Source="Nicolas_upshifts" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="upshifts" S_feature 2811678..2812447 /Source="Nicolas_S_feature" /locus_tag="new_3307598_3308367" /HighExp="Etha, Salt, Gly, M9-stat, Sw, LoTm, B60, BC, Heat, S0" /AntisenseName="yutK" /AntisenseCor="-0.36240965013078302" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1243" promotor_-10 complement(2812348..2812367) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-10" upshifts complement(2812353) /Source="Nicolas_upshifts" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="upshifts" promotor_-35 complement(2812382..2812389) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-35" downshifts 2812404 /Source="Nicolas_upshifts" /id="D1668" /incds=0 /nref=3 /ntot=58 /MaxReadThrough="4.13852" /MaxDrop="3.94079" /score="20.5760616" /energy="-10.5" /TU="U2521" /idTUdmin="U2521" /TUdmin="-1913" /isTUend="FALSE" /label="downshifts" CDS complement(2812448..2812684) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391099.1" /db_xref="EnsemblGenomes-Gn:BSU32190" /db_xref="EnsemblGenomes-Tr:CAB15209" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR022916" /db_xref="SubtiList:BG14051" /db_xref="UniProtKB/Swiss-Prot:O32116" /translation="MNPMIEFCVSNLAHGSQEARAILEKDPNLDVLEYGCLSYCGTCM ESLFALVNGEVVMGETPAELVENIYTFIEENPMF*" /label="yuzB CDS" gene complement(2812448..2812684) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /label="yuzB gene" S_feature 2812449..2812865 /Source="Nicolas_S_feature" /locus_tag="new_3308369_3308785" /HighExp="Salt, LoTm, Gly, Etha, Sw, Heat, S0, C30, M9-stat, Mal" /AntisenseName="yuzB" /AntisenseCor="-5.6824456709843603E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1244" downshifts complement(2812466) /Source="Nicolas_upshifts" /id="D1669" /incds=0 /nref=175 /ntot=239 /MaxReadThrough="1.28789" /MaxDrop="7.32368" /score="41.4640292" /energy="-10.5" /TU="NA" /idTUdmin="U2523" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2812649..2812650) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2812654..2812658) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2812656) /Source="Nicolas_upshifts" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2812699..2812718) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2812700) /Source="Nicolas_upshifts" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2812732..2812739) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2812842..2812847 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2812861..2812880 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2812867 /Source="Nicolas_upshifts" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="upshifts" CDS 2812947..2814014 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /EC_number="1.6.-.-" /function="16.10: Respire" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17015645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH dehydrogenase" /protein_id="NP_391100.2" /db_xref="EnsemblGenomes-Gn:BSU32200" /db_xref="EnsemblGenomes-Tr:CAB15210" /db_xref="GOA:O32117" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14046" /db_xref="UniProtKB/Swiss-Prot:O32117" /translation="MKKLVLIGGGYGNMRVLHRLLPNQLPDDVSITLIDRNPYHCLKT EYYALAAGTISDHHIRVSFPEHPRLDVQYGDITSIDIVQKQVLFQDREPISYDDAIIG LGCEDKYHNVPGAPEFTYSIQTIDQSRETYQKLNNLSANATVAIVGAGLSGVELASEL RESRDDLNIILFDRGNLILSSFPERLSKYVQKWFEEHGVRIINRANITKVEEGVVYNH DDPISADAIVWTAGIQPNKVVRDLDVEKDAQGRIVLTPHHNLPGDEHLYVVGDCASLP HAPSAQLAEAQAEQIVQILQKRWNGEALPESMPQFKLKGVLGSLGKKAGFGLVADRPL IGRVPRMLKSGLLWMYKHHNG*" /label="yutJ CDS" gene 2812947..2814014 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /label="yutJ gene" downshifts 2813998 /Source="Nicolas_upshifts" /id="D1670" /incds=0 /nref=4 /ntot=110 /MaxReadThrough="3.51945" /MaxDrop="3.02708" /score="6.15657679" /energy="-10.8" /TU="U2521,U2525" /idTUdmin="U2521" /TUdmin="-319" /isTUend="FALSE" /label="downshifts" CDS complement(2814040..2814366) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11551182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reduction management enzyme" /protein_id="NP_391101.1" /db_xref="EnsemblGenomes-Gn:BSU32210" /db_xref="EnsemblGenomes-Tr:CAB15211" /db_xref="InterPro:IPR009190" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14053" /db_xref="UniProtKB/Swiss-Prot:O32118" /translation="MMKPVMLSVYGAENVCASCVNMPTAKDTYEWLEAALKRKYPNQP FEMQYIDIHEPPDNEHAKELAEKIRNDEYFYPLVLVEDKIVGEGNPKLKDVYEEMEKH GYTENR*" /label="yuzD CDS" gene complement(2814040..2814366) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /label="yuzD gene" downshifts complement(2814063) /Source="Nicolas_upshifts" /id="D1671" /incds=0 /nref=4 /ntot=180 /MaxReadThrough="1.63835" /MaxDrop="3.17377" /score="-8.05690984" /energy="-10.8" /TU="NA" /idTUdmin="U2526" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2814398..2814417) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2814415) /Source="Nicolas_upshifts" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2814430..2814437) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2814450..2814454 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2814466..2814801 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17237162, 21749987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative iron-sulfur scaffold protein" /protein_id="NP_391102.1" /db_xref="EnsemblGenomes-Gn:BSU32220" /db_xref="EnsemblGenomes-Tr:CAB15212" /db_xref="GOA:O32119" /db_xref="InterPro:IPR001075" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG14045" /db_xref="UniProtKB/Swiss-Prot:O32119" /translation="MCYNRESNFANQTIDFYCYTEYNGFMTTKGANVMTEVEMKEQVQ EVLDKLRPFLLRDGGDCELVDVDEGIVKLRLLGACGSCPSSTITLKAGIERALLEEVP GVVEVEQVF*" /label="yutI CDS" gene 2814466..2814801 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /label="yutI gene" promotor_-10 2814467..2814486 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2814472 /Source="Nicolas_upshifts" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2814591) /Source="Nicolas_upshifts" /id="D1672" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="1.28655" /MaxDrop="3.45909" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 2814779 /Source="Nicolas_upshifts" /id="D1673" /incds=0 /nref=258 /ntot=281 /MaxReadThrough="3.6035" /MaxDrop="7.98922" /score="39.7008566" /energy="-19.5" /TU="U2527" /idTUdmin="U2527" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(2814843..2816816) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8576092, 11406580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acylaminoacyl-peptidase" /protein_id="NP_391103.2" /db_xref="EnsemblGenomes-Gn:BSU32230" /db_xref="EnsemblGenomes-Tr:CAB15213" /db_xref="GOA:P39839" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10463" /db_xref="UniProtKB/Swiss-Prot:P39839" /translation="MKKLITADDITAIVSVTDPQYAPDGTRAAYVKSQVNQEKDSYTS NIWIYETKTGGSVPWTHGEKRSTDPRWSPDGRTLAFISDREGDAAQLYIMSTEGGEAR KLTDIPYGVSKPLWSPDGESILVTVSLGEGESIDDREKTEQDSYEPVEVQGLSYKRDG KGLTRGAYAQLVLVSVKSGEMKELTSHKADHGDPAFSPDGKWLVFSANLTETDDASKP HDVYIMSLESGDLKQVTPHRGSFGSSSFSPDGRYLALLGNEKEYKNATLSKAWLYDIE QGRLTCLTEMLDVHLADALIGDSLIGGAEQRPIWTKDSQGFYVIGTDQGSTGIYYISI EGLVYPIRLEKEYINSFSLSPDEQHFIASVTKPDRPSELYSIPLGQEEKQLTGANDKF VREHTISIPEEIQYATEDGVMVNGWLMRPAQMEGETTYPLILNIHGGPHMMYGHTYFH EFQVLAAKGYAVVYINPRGSHGYGQEFVNAVRGDYGGKDYDDVMQAVDEAIKRDPHID PKRLGVTGGSYGGFMTNWIVGQTNRFKAAVTQRSISNWISFHGVSDIGYFFTDWQLEH DMFEDTEKLWDRSPLKYAANVETPLLILHGERDDRCPIEQAEQLFIALKKMGKETKLV RFPNASHNLSRTGHPRQRIKRLNYISSWFDQHL*" /label="yuxL CDS" gene complement(2814843..2816816) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /label="yuxL gene" downshifts complement(2814855) /Source="Nicolas_upshifts" /id="D1674" /incds=0 /nref=19 /ntot=114 /MaxReadThrough="1.79797" /MaxDrop="3.85507" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2816831..2816849) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2816854) /Source="Nicolas_upshifts" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2816861..2816869) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2816924..2817853) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /EC_number="2.7.1.39" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine kinase" /protein_id="NP_391104.1" /db_xref="EnsemblGenomes-Gn:BSU32240" /db_xref="EnsemblGenomes-Tr:CAB15214" /db_xref="GOA:P04948" /db_xref="InterPro:IPR000870" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10462" /db_xref="UniProtKB/Swiss-Prot:P04948" /translation="MNEADMLFSVTVPGSTANLGPGFDSVGMALSRYLKLTVFESDKW SFEAETETVAGIPAGTDNLIYQVAKRTADLYGKEMPPVHVKVWSDIPLARGLGSSAAA IVAAIELADELCGLKLSEADKLHLASLEEGHPDNAGASLVGGLVIGLHEDDETQMIRV PNADIDVVVVIPFYEVLTRDARDVLPKEFPYADAVKASAVSNILIAAIMSKDWPLVGK IMKKDMFHQPYRAMLVPELSKVEHVAEMKGAYGTALSGAGPTILVMTEKGKGEELKEQ LALHFPHCEVDALTVPKEGSIIERNPLYQVKSV*" /label="thrB CDS" gene complement(2816924..2817853) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /label="thrB gene" downshifts complement(2816937) /Source="Nicolas_upshifts" /id="D1675" /incds=0 /nref=222 /ntot=261 /MaxReadThrough="2.39521" /MaxDrop="7.03759" /score="15.5945196" /energy="-10.3" /TU="NA" /idTUdmin="U2530" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(2817850..2818908) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /EC_number="4.2.3.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 3139660, 8768250" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 3139660, 8768250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine synthase" /protein_id="NP_391105.1" /db_xref="EnsemblGenomes-Gn:BSU32250" /db_xref="EnsemblGenomes-Tr:CAB15215" /db_xref="GOA:P04990" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR004450" /db_xref="InterPro:IPR026260" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10461" /db_xref="UniProtKB/Swiss-Prot:P04990" /translation="MWKGLIHQYKEFLPVTDQTPALTLHEGNTPLIHLPKLSEQLGIE LHVKTEGVNPTGSFKDRGMVMAVAKAKEEGNDTIMCASTGNTSAAAAAYAARANMKCI VIIPNGKIAFGKLAQAVMYGAEIIAIDGNFDDALKIVRSICEKSPIALVNSVNPYRIE GQKTAAFEVCEQLGEAPDVLAIPVGNAGNITAYWKGFKEYHEKNGTGLPKMRGFEAEG AAAIVRNEVIENPETIATAIRIGNPASWDKAVKAAEESNGKIDEVTDDEILHAYQLIA RVEGVFAEPGSCASIAGVLKQVKSGEIPKGSKVVAVLTGNGLKDPNTAVDISEIKPVT LPTDEDSILEYVKGAARV*" /label="thrC CDS" gene complement(2817850..2818908) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /label="thrC gene" CDS complement(2818908..2820209) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /EC_number="1.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3139660, 27299409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3139660, 27299409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine dehydrogenase" /protein_id="NP_391106.1" /db_xref="EnsemblGenomes-Gn:BSU32260" /db_xref="EnsemblGenomes-Tr:CAB15216" /db_xref="GOA:P19582" /db_xref="InterPro:IPR001342" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005106" /db_xref="InterPro:IPR016204" /db_xref="InterPro:IPR019811" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10460" /db_xref="UniProtKB/Swiss-Prot:P19582" /translation="MKAIRVGLLGLGTVGSGVVKIIQDHQDKLMHQVGCPVTIKKVLV KDLEKKREVDLPKEVLTTEVYDVIDDPDVDVVIEVIGGVEQTKQYLVDALRSKKHVVT ANKDLMAVYGSELLAEAKENGCDIYFEASVAGGIPILRTLEEGLSSDRITKMMGIVNG TTNFILTKMIKEKSPYEEVLKEAQDLGFAEADPTSDVEGLDAARKMAILARLGFSMNV DLEDVKVKGISQITDEDISFSKRLGYTMKLIGIAQRDGSKIEVSVQPTLLPDHHPLSA VHNEFNAVYVYGEAVGETMFYGPGAGSMPTATSVVSDLVAVMKNMRLGVTGNSFVGPQ YEKNMKSPSDIYAQQFLRIHVKDEVGSFSKITSVFSERGVSFEKILQLPIKGHDELAE IVIVTHHTSEADFSDILQNLNDLEVVQEVKSTYRVEGNGWS*" /label="hom CDS" gene complement(2818908..2820209) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /label="hom gene" promotor_-35 2820094..2820103 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2820118..2820137 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2820125 /Source="Nicolas_upshifts" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2820210..2820291) /Source="Nicolas_S_feature" /locus_tag="new_3316130_3316211_c" /HighExp="T3.0H, T2.30H, T3.30H, S2, C90, T4.0H, BMM, SMM, MG 120, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1245" promotor_-10 complement(2820276..2820295) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2820291) /Source="Nicolas_upshifts" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2820293..2820409) /Source="Nicolas_S_feature" /locus_tag="new_3316213_3316329_c" /HighExp="S5, S3, S4, S7, S6, S8, BT, B36, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1246" promotor_-35 complement(2820310..2820317) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2820410..2821429) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /function="16.3: Control" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15231775, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat-associated protein" /protein_id="NP_391107.1" /db_xref="EnsemblGenomes-Gn:BSU32270" /db_xref="EnsemblGenomes-Tr:CAB15217" /db_xref="GOA:O32123" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014254" /db_xref="SubtiList:BG14044" /db_xref="UniProtKB/Swiss-Prot:O32123" /translation="MVKGTIKEKYGIHIRQLSMYQHTYQCFQTPNSYFLIVPVSQFSE TELAELYYMSQYLQEQSDPYVSVFIFTKEGELTFEHEGKTYALLKAAPPYSNRAFSIG AELAEFHRKGRGYPYEVKAAGRIGQWKDLWGKRIDQLEAFWQRKVQTPPHEPFDKKMI ESFPYYLGLSENAIQYLVDTELDDKPQAADSGTICHQRMERHTWSPESLIRIPADWVF DHASRDLAEYMRHTFLHHRQDFNQQGFLFLQEYEQVTPLSSFSKRLLYSRLLFPLHYF EIVESYYMSSESEKHYFEEQLDFILNDCGRYEQFLNTAQEFMNMRAQKLFVPRVSWLG KGSSR*" /label="cotNH CDS" gene complement(2820410..2821429) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /label="cotNH gene" promotor_-35 2821237..2821242 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2821258..2821276 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2821262 /Source="Nicolas_upshifts" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2821452..2821470) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2821459) /Source="Nicolas_upshifts" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2821468..2821473 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2821486..2821491) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2821489..2821553 /Source="Nicolas_S_feature" /locus_tag="new_3317409_3317473" /HighExp="S4, S5, S3, S6, S7, B36, S8, LoTm, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1247" promotor_-10 2821489..2821507 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2821489 /Source="Nicolas_upshifts" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2821526..2821535 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2821548..2821567 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2821555 /Source="Nicolas_upshifts" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="upshifts" CDS 2821582..2822082 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_391108.1" /db_xref="EnsemblGenomes-Gn:BSU32280" /db_xref="EnsemblGenomes-Tr:CAB15218" /db_xref="GOA:O32124" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="SubtiList:BG14043" /db_xref="UniProtKB/Swiss-Prot:O32124" /translation="MSENEQFSQMEAKARARMKERGVEVSDIAELVFFLQKKYHPDLT IDECTLNVNRVLAKREVQNAILTGIELDVLAEQKKLSEPLQTMLEIDESLYGVDEVLA FSIVNIYGSIGFTNYGYIDKEKPGILKRLNDKSTGECHTFLDDIVGAISAAASSRLAH RARHTE*" /label="yutG CDS" gene 2821582..2822082 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /label="yutG gene" CDS complement(2822109..2822879) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /EC_number="3.1.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15664928, 16766528, 27907199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15664928, 16766528, 27907199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5' nucleotidase, promiscuous" /protein_id="NP_391109.1" /db_xref="EnsemblGenomes-Gn:BSU32290" /db_xref="EnsemblGenomes-Tr:CAB15219" /db_xref="GOA:O32125" /db_xref="InterPro:IPR006354" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3PDW" /db_xref="SubtiList:BG14042" /db_xref="UniProtKB/Swiss-Prot:O32125" /translation="MKTYKGYLIDLDGTMYNGTEKIEEACEFVRTLKDRGVPYLFVTN NSSRTPKQVADKLVSFDIPATEEQVFTTSMATAQHIAQQKKDASVYVIGEEGIRQAIE ENGLTFGGENADFVVVGIDRSITYEKFAVGCLAIRNGARFISTNGDIAIPTERGLLPG NGSLTSVLTVSTGVQPVFIGKPESIIMEQAMRVLGTDVSETLMVGDNYATDIMAGINA GMDTLLVHTGVTKREHMTDDMEKPTHAIDSLTEWIPYI*" /label="nucF CDS" gene complement(2822109..2822879) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /label="nucF gene" downshifts complement(2822137) /Source="Nicolas_upshifts" /id="D1676" /incds=0 /nref=137 /ntot=243 /MaxReadThrough="2.15034" /MaxDrop="4.82801" /score="8.09889752" /energy="-15.6" /TU="NA" /idTUdmin="U2535" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2822908..2823342) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391110.1" /db_xref="EnsemblGenomes-Gn:BSU32300" /db_xref="EnsemblGenomes-Tr:CAB15220" /db_xref="InterPro:IPR008201" /db_xref="PDB:1YLM" /db_xref="SubtiList:BG14041" /db_xref="UniProtKB/Swiss-Prot:O32126" /translation="MYFVDRSKIEKTLGFFEHQLALFDSQTDWQSEIGELALQRIGHL LIECILDTGNDMIDGFIMRDPGSYDDIMDILVDEKVVTEKEGDELKKLIAYRKTLVQQ YLLADSGELYRLIKAHQTALQDFPKRIRSYLETELGPVSAFK*" /label="yutE CDS" gene complement(2822908..2823342) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /label="yutE gene" CDS complement(2823366..2823641) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12770717, 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391111.2" /db_xref="EnsemblGenomes-Gn:BSU32310" /db_xref="EnsemblGenomes-Tr:CAB15221" /db_xref="InterPro:IPR009370" /db_xref="PDB:2KL5" /db_xref="SubtiList:BG14040" /db_xref="UniProtKB/Swiss-Prot:O32127" /translation="MILIQNAEFELVHNFKDGFNEEAFKARYSDILNKYDYIVGDWGY GQLRLKGFFDDQNQKATFETKISTLDEYIYEYCNFGCAYFVLKRIRK*" /label="yutD CDS" gene complement(2823366..2823641) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /label="yutD gene" promotor_-10 complement(2823661..2823680) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2823686) /Source="Nicolas_upshifts" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2823688..2824380) /Source="Nicolas_S_feature" /locus_tag="new_3319608_3320300_c" /HighExp="G135, G150, G180, H2O2, LBGtran, LBGexp, Paraq, dia15, C90, HiOs" /AntisenseName="yutC" /AntisenseCor="-0.57886192731570996" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1248" promotor_-35 complement(2823694..2823701) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2823704..2823710 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2823725..2823736 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2823733 /Source="Nicolas_upshifts" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="upshifts" CDS 2823756..2824388 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative sporulation-related lipoprotein" /protein_id="NP_391112.1" /db_xref="EnsemblGenomes-Gn:BSU32320" /db_xref="EnsemblGenomes-Tr:CAB15222" /db_xref="GOA:O32128" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG14039" /db_xref="UniProtKB/Swiss-Prot:O32128" /translation="MKRTAVSLCLLTGLLSGCGGAGLDNAQNVRNQTQNQTKPIHVSD RNEAFNRHNENEQFGYVRYQKEQFDGEQQKTPVMNREETAHMISSLTVQLPHIQDAAT LVTDREALVVYKTDSKNRELTADQVKKTAASVIPRYYHVYISDNPNHMQSVENYSNLG SGSRDIREIMSGTIQEMKTSPQGSPVSENENANGETRQDMKIDRNDKNAR*" /label="yutC CDS" gene 2823756..2824388 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /label="yutC gene" downshifts 2824349 /Source="Nicolas_upshifts" /id="D1677" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="1.84979" /MaxDrop="3.55825" /score="-2.38634221" /energy="-9.6" /TU="NA" /idTUdmin="U2536" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2824404..2825300) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /EC_number="2.8.1.8" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15362861, 16835858, 19028902, 19820084, 25341020; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoyl synthase (lipoic acid synthetase)" /protein_id="NP_391113.2" /db_xref="EnsemblGenomes-Gn:BSU32330" /db_xref="EnsemblGenomes-Tr:CAB15223" /db_xref="GOA:O32129" /db_xref="InterPro:IPR003698" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031691" /db_xref="SubtiList:BG14038" /db_xref="UniProtKB/Swiss-Prot:O32129" /translation="MAKKDEHLRKPEWLKIKLNTNENYTGLKKLMRENNLHTVCEEAK CPNIHECWAVRRTATFMILGSVCTRACRFCAVKTGLPTELDLQEPERVADSVALMNLK HAVITAVARDDQKDGGAGIFAETVRAIRRKSPFTTIEVLPSDMGGNYDNLKTLMDTRP DILNHNIETVRRLTPRVRARATYDRSLEFLRRAKEMQPDIPTKSSIMIGLGETKEEII EVMDDLLANNVDIMAIGQYLQPTKKHLKVQKYYHPDEFAELKEIAMQKGFSHCEAGPL VRSSYHADEQVNEASKKRQAQA*" /label="lipA CDS" gene complement(2824404..2825300) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /label="lipA gene" downshifts complement(2824425) /Source="Nicolas_upshifts" /id="D1678" /incds=0 /nref=186 /ntot=261 /MaxReadThrough="3.83236" /MaxDrop="5.33309" /score="14.803008" /energy="-9.6" /TU="U2537" /idTUdmin="U2537" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" S_feature complement(2825301..2825435) /Source="Nicolas_S_feature" /locus_tag="new_3321221_3321355_c" /HighExp="HiOs, LBGtran, dia15, dia5, C90, Diami, dia0, LBGexp, Heat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1249" promotor_-10 complement(2825422..2825441) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-10" upshifts complement(2825435) /Source="Nicolas_upshifts" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="upshifts" promotor_-35 complement(2825457..2825461) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-35" promotor_-35 2825475..2825481 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2825495..2825506 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2825507 /Source="Nicolas_upshifts" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="upshifts" CDS 2825535..2826515 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /EC_number="3.4.-.-" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12813075; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific L-Ala-D-Glu endopeptidase" /protein_id="NP_391114.2" /db_xref="EnsemblGenomes-Gn:BSU32340" /db_xref="EnsemblGenomes-Tr:CAB15224" /db_xref="GOA:O32130" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG13975" /db_xref="UniProtKB/Swiss-Prot:O32130" /translation="MKVLLSALLLLLFAFEPSASGKKLSDPVLSKRMELYHKIEAVTQ IPWYALAAVDQYEENVRSNRKDLPEKAGIISIYIPDDIWSGPENPNPKDDAPLSIKVF DGIGMDGDGDGKAEVSNDEDILYTFSQYLLSYGTDEDNIRIGLWNYYRRDQTVGIISE FMKLFKAYGHIDLGEHAFPLPIRTDYSYRSTWGDARGFGGRRIHEGTDIFAHYGLPVK STCYGVVEMKGWNRFGGWRIGIRDINNTYHYFAHLNGFAKGIKTGQIVEPGQVIGSVG SSGYGPPGTAGKFPPHLHYGMYKDNGRTEWSFDPYPHLRAWERYEYQKKK*" /label="lytH CDS" gene 2825535..2826515 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /label="lytH gene" upshifts complement(2825613) /Source="Nicolas_upshifts" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2825627..2825646) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2825663..2825666) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2826507 /Source="Nicolas_upshifts" /id="D1679" /incds=0 /nref=35 /ntot=74 /MaxReadThrough="0.613989999999999" /MaxDrop="8.59238" /score="-3.31011906" /energy="-20" /TU="NA" /idTUdmin="U2538" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2826543..2827307) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12662922, 23388828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 23388828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein required for membrane fission during spore formation" /protein_id="NP_391115.1" /db_xref="EnsemblGenomes-Gn:BSU32350" /db_xref="EnsemblGenomes-Tr:CAB15225" /db_xref="GOA:O32131" /db_xref="InterPro:IPR014197" /db_xref="SubtiList:BG13976" /db_xref="UniProtKB/Swiss-Prot:O32131" /translation="MPRYRGPFRKRGPLPFRYVMLLSVVFFILSTTVSLWMINGSIKP VLMDIGEMETKRIATEVIQDSIEDYMSDSENMKDMFQMNSDENGNLTTIDFNTQVVNS VKTKVTKQLQAHLKEMETHTGHSGASENIMINIPLGQVTGNSLLGNLGPKIPVRFNLI GDAFTDVKTKIKPYGINNALIDISIFVEIKVKVIIPFASKTAVVTNNVPVSIKAVQGE VPQFYNGSGGSGVTPSVQLPSSKENGADSKKEKSSK*" /label="fisB CDS" gene complement(2826543..2827307) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /label="fisB gene" downshifts complement(2826559) /Source="Nicolas_upshifts" /id="D1680" /incds=0 /nref=74 /ntot=226 /MaxReadThrough="3.15258" /MaxDrop="6.53891" /score="23.5286262" /energy="-12.4" /TU="NA" /idTUdmin="U2540" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2827321..2827339) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2827329) /Source="Nicolas_upshifts" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2827355..2827360) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2827380..2827685) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391116.1" /db_xref="EnsemblGenomes-Gn:BSU32360" /db_xref="EnsemblGenomes-Tr:CAB15226" /db_xref="InterPro:IPR014931" /db_xref="InterPro:IPR036493" /db_xref="SubtiList:BG13977" /db_xref="UniProtKB/Swiss-Prot:O32132" /translation="MVNLTPIMIEGQPFTAVTVKLPKTNFMAVANDHGYIMCGALDVA LLNEKLKERGIVAGRAVGVRTIDQLLDAPLESVTYAAEDLGIKVGMSGREALLKMMK* " /label="yunC CDS" gene complement(2827380..2827685) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /label="yunC gene" downshifts complement(2827388) /Source="Nicolas_upshifts" /id="D1681" /incds=0 /nref=3 /ntot=128 /MaxReadThrough="5.18714" /MaxDrop="3.9347" /score="-2.65376612" /energy="-18.9" /TU="U2541,U2543,U2544" /idTUdmin="U2540" /TUdmin="-829" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2827699..2827718) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2827722) /Source="Nicolas_upshifts" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2827732..2827740) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2827750..2829138) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nuclease/nucleotidase/phosphoesterase" /protein_id="NP_391117.1" /db_xref="EnsemblGenomes-Gn:BSU32370" /db_xref="EnsemblGenomes-Tr:CAB15227" /db_xref="GOA:O32133" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR011240" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG13978" /db_xref="UniProtKB/Swiss-Prot:O32133" /translation="MKEKLRLYHTNDLHSHFENWPKIVDYIEQKRKEHQSDGEETLVF DIGDHLDRFQFVTEATFGKANVDLLNRLHIDGAAIGNNEGITLPHEELAALYDHAEFP VIVSNLFDKNGNRPSWAVPYHIKSLKNGMSIAFLGVTVPYYPVYDKLGWTVTDALESI KETILEVKGQADIIVLLSHLGILDDQAVAEAVPEIDVILESHTHHLLEDGQVVNGVLL ASAEKYGHYVGCVEITVDSVQRSINSKTASVQNMAEWTGESAETKAFLNEKEREAEEK LSDAVAELAQDAEVKWFEESELPLLLAYALKEWCETDISMVNSGVILGPLKAGPVTKL DLHRICPHPINPVAVRLTGEELKETIVHAASEQMEQLRIKGLGFRGEVMGKMVYAGVE VETKRLDDGITHVTRITLNGEDIEKHKQYSVAVLDMFTLGKLFPLIRDAAEKEYFMPE FLRDLLAWKLAQ*" /label="yunD CDS" gene complement(2827750..2829138) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /label="yunD gene" CDS complement(2829158..2829979) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391118.1" /db_xref="EnsemblGenomes-Gn:BSU32380" /db_xref="EnsemblGenomes-Tr:CAB15228" /db_xref="GOA:O32134" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13979" /db_xref="UniProtKB/Swiss-Prot:O32134" /translation="MSFVILVVLGLIAGTVGSLIGLGGGIVIVPSLMFLSTVTQLFQD VTPQVAIGTSLLVIIFTGLSSTLAYIKYKTVDYKSGLIFFIGSGPGSMIGAYVSKLFN SNSFSVWFGIFMILISLSLMLKAKARPINKAHKGIIRTFQDDAGEPYTYSYQASVGIA IAFVVGFLGGLFGIGGGSLMVPAMMLLFLFPPKVAVATSMFIIFLSSMTGSVSHMISG HVNWLYALALVPGAWFGGKLGAAINRKMQTKTIVMIMRIVLILIGCQLIYEGIFS*" /label="yunE CDS" gene complement(2829158..2829979) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /label="yunE gene" CDS complement(2829997..2830845) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391119.2" /db_xref="EnsemblGenomes-Gn:BSU32390" /db_xref="EnsemblGenomes-Tr:CAB15229" /db_xref="InterPro:IPR002763" /db_xref="InterPro:IPR036520" /db_xref="SubtiList:BG13980" /db_xref="UniProtKB/Swiss-Prot:O32135" /translation="MIYIGLTGWGDHDSIYPPKTASQKKLQAYSSHFPIVELDASFYA IQPARNNEKWVKETPETFQFIVKAYQGMTGHQRGEIPFDSKEEMFDAFKVSLTPYLHS NKLAMVLFQFPPWFDCKKENVAYLRWCKHQMGDIPCALEFRNRSWFSPPFYEQTLSFM KAEGWIHSVCDEPQIGEGSVPTVLRATDENKTLVRFHGRNKQGWMKPDGGKNWREVRY LYRYNQQELEDWKKHLNELQQQCKDVFVLFNNNSGGDAADNGKQMLELLDIEYSGLAP RQLDLF*" /label="yunF CDS" gene complement(2829997..2830845) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /label="yunF gene" promotor_-35 2830364..2830369 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2830385..2830403 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2830399 /Source="Nicolas_upshifts" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2830856..2830875) /Source="Nicolas_upshift_promotors" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2830871) /Source="Nicolas_upshifts" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2830883..2831230) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391120.1" /db_xref="EnsemblGenomes-Gn:BSU32400" /db_xref="EnsemblGenomes-Tr:CAB15230" /db_xref="SubtiList:BG13981" /db_xref="UniProtKB/Swiss-Prot:O32136" /translation="MEHVKYILKQSWSRHSSSKWTEECPSCGQCGVTALVIQDHFGGT IFKTRVDESWHFYNSINGVVYDFTSEQFQAPIEYQHIPSSREEAFLDTNEEQYQHLRE AFSRHMNSISEET*" /label="yunG CDS" gene complement(2830883..2831230) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /label="yunG gene" promotor_-10 complement(2831243..2831262) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2831262) /Source="Nicolas_upshifts" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2831276..2831282) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2831327..2832667) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /EC_number="3.5.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoinase" /protein_id="NP_391121.1" /db_xref="EnsemblGenomes-Gn:BSU32410" /db_xref="EnsemblGenomes-Tr:CAB15231" /db_xref="GOA:O32137" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR017593" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13982" /db_xref="UniProtKB/Swiss-Prot:O32137" /translation="MAYDMVIKGAKAVTPDGVIEADIVVQNGVIAEIGSDIEASGTEI IQADGKYVFPGVIDCHVHFNEPGREDWEGFETGSQMMAAGGCTTYFDMPLNCIPSTVT AEHLLAKAELGRQKSAVDFALWGGLVPGHIEDIRPMAEAGAIGFKAFLSKSGTDEFRS VDERTLLKGMAEIAAAGKILALHAESDAITSYLQMVLANKGKVDADAYAASRPEEAEV EAVYRTIQYAKVTGCPVHFVHISTAKAVRLIREAKQEGLDVSVETCPHYVLFSHDDLR QRGSVAKCAPPLRSRQSKETLIETLIAGDIDMVSSDHSPCRPSLKREDNMFLSWGGIS GGQFTLLGMLELALEHQIPFETIAEWTAAAPAKRFGLQKKGRLEAGCDADFVLVSMEP YTVTRESMFAKHKKSIYEGHTFPCSISATYSKGRCVYNDGEKVTEIDGALVVPS*" /label="pucH CDS" gene complement(2831327..2832667) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /label="pucH gene" downshifts complement(2831355) /Source="Nicolas_upshifts" /id="D1682" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.88847" /MaxDrop="3.89144" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-4796" /isTUend="FALSE" /label="downshifts" downshifts complement(2832411) /Source="Nicolas_upshifts" /id="D1683" /incds=1 /nref=1 /ntot=7 /MaxReadThrough="3.38784" /MaxDrop="3.36547" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-5852" /isTUend="FALSE" /label="downshifts" promotor_-35 2832724..2832730 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2832744..2832763 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2832746..2832764) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2832752 /Source="Nicolas_upshifts" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="upshifts" S_feature 2832753..2832841 /Source="Nicolas_S_feature" /locus_tag="new_3328673_3328761" /HighExp="BT, Cold, S0, LBGexp, S1, Lbtran, G150, T-1.40H, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S1250" upshifts complement(2832763) /Source="Nicolas_upshifts" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2832780..2832785) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2832842..2834437 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 12374841" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 12374841; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine degradation operon" /protein_id="NP_391122.1" /db_xref="EnsemblGenomes-Gn:BSU32420" /db_xref="EnsemblGenomes-Tr:CAB15232" /db_xref="GOA:O32138" /db_xref="InterPro:IPR012914" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG13983" /db_xref="UniProtKB/Swiss-Prot:O32138" /translation="MNILDVMKIPAFENANLIAGKAGGEREVQHVNMMDAPDIVDFLH KNELLVTTAYHLKDHPHQLSELIRQMAKRGCAGLGIKTKRYLEDIPKEIIELADSYAF PIIELPEHIRLGDIVNATLSHILDMRSNELQQAIYAHKKFTNHIMSGKGLQSLLKKVS DILQLPVLLLDQHAKMLSASHQISVETEKLKGTLNTVSGPFFTCFSTISDQKTYSVLP IYNHEKNCGYLLIPDMVQAGDKGLILTIEQAANVISFELLKENALKQFSRRARNEFFN NFIERTFSSDDEIKNRAKEFKLRWDQKYMCIAGKLDRNDESISFTENQLASDSVFEFL EGELSAFPFPPHFFMKGNVGIILIEATDSWSEMHASVISFLEQFQTQVSAQFKRTVSF GISNICQKLIDVPDAFTEASDALQSGHLSRSTAFIQVYHAKDVPELLRLLPVEDLKKF YNSTLQSLAEKQQEDQSLLHTLSVYLETHCQISETAKRLYVHRNTVIYRLEKCEELLG KSLKDPETTMRLRLALRMQRLIS*" /label="pucR CDS" gene 2832842..2834437 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /label="pucR gene" CDS 2834582..2835931 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease" /protein_id="NP_391123.1" /db_xref="EnsemblGenomes-Gn:BSU32430" /db_xref="EnsemblGenomes-Tr:CAB15233" /db_xref="GOA:O32139" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13984" /db_xref="UniProtKB/Swiss-Prot:O32139" /translation="MKKRSFKVFTLSLQHVLAMYAGAILVPLLVGRALNVTTEQLSYL LAIDLLTCGVATLLQTLRGTYIGIGLPVMLGSSFVAVTPMIAIGSNYGIHAIYGSIIA AGVFIFLFARFFGKLTVLFPPVVTGTVVTLIGLSLVPTGVKNMAGGEKINGSANPEYG SLENLLLSVGVLVLILVLNRFLKGFARTLSVLIGIAAGTAAAAIMGKVSFSSVTEAPF FQIPKPFYFGAPAFEIGPILTMLIVGIVIIVESTGVFYAIGKICGRPLTDKDLVKGYR AEGIAILIGGLFNAFPYNTFAQNAGLLQLTKVKTRNIVVTAGCILVCLGLIPKIAALA SAVPAAVLGGATVVMFGMVIASGVKMLSTADLKNQYHLLTIACSIALGIGASTAPGIF AEFPAPIRILVSDGTITGSLTAIFLNLFFSLRDKKELTAQQTELPVLEHTLALEKEV* " /label="pucJ CDS" gene 2834582..2835931 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /label="pucJ gene" CDS 2835937..2837229 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease subunit" /protein_id="NP_391124.1" /db_xref="EnsemblGenomes-Gn:BSU32440" /db_xref="EnsemblGenomes-Tr:CAB15234" /db_xref="GOA:O32140" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13985" /db_xref="UniProtKB/Swiss-Prot:O32140" /translation="MKEQHNALQLMMLGLQHMLAMYAGAILVPLIVGAAIGLNAGQLT YLIAIDLFMCGAATLLQLWRNRYFGIGLPVVLGCTFTAVGPMISIGSTYGVPAIYGAI IAAGLIVVLAAGFFGKLVRFFPPVVTGSVVMIIGISLIPTAMNNLAGGEGSKEFGSLD NVLLGFGVTAFILLLFYFFKGFIRSIAILLGLIAGTAAAYFMGKVDFSEVLEASWLHV PSLFYFGPPTFELPAVVTMLLVAIVSLVESTGVYFALADITNRRLSEKDLEKGYRAEG LAILLGGLFNAFPYTAFSQNVGIVQLSKMKSVNVIAITGIILVAIGLVPKAAALTTVI PTPVLGGAMIVMFGMVISYGIKMLSSVDLDSQGNLLIIASSVSLGLGATTVPALFSSL SGAASVLAGSGIVIGSLTAIALHAFFQTKQPNSADIKT*" /label="pucK CDS" gene 2835937..2837229 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /label="pucK gene" CDS 2837242..2838726 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /EC_number="1.7.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12823818, 17567580, 20168977, 23760935, 28531234" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12823818, 17567580, 20168977, 23760935, 28531234; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="urate oxidase with peroxide reductase N-terminaldomain" /protein_id="NP_391125.1" /db_xref="EnsemblGenomes-Gn:BSU32450" /db_xref="EnsemblGenomes-Tr:CAB15235" /db_xref="GOA:O32141" /db_xref="InterPro:IPR002042" /db_xref="InterPro:IPR017580" /db_xref="InterPro:IPR018020" /db_xref="InterPro:IPR019842" /db_xref="InterPro:IPR036778" /db_xref="SubtiList:BG13986" /db_xref="UniProtKB/Swiss-Prot:O32141" /translation="MFTMDDLNQMDTQTLTDTLGSIFEHSSWIAERSAALRPFSSLSD LHRKMTGIVKAADRETQLDLIKKHPRLGTKKTMSDDSVREQQNAGLGKLEQQEYEEFL MLNEHYYDRFGFPFILAVKGKTKQDIHQALLARLESERETEFQQALIEIYRIARFRLA DIITEKGETQMKRTMSYGKGNVFAYRTYLKPLTGVKQIPESSFAGRDNTVVGVDVTCE IGGEAFLPSFTDGDNTLVVATDSMKNFIQRHLASYEGTTTEGFLHYVAHRFLDTYSHM DTITLTGEDIPFEAMPAYEEKELSTSRLVFRRSRNERSRSVLKAERSGNTITITEQYS EIMDLQLVKVSGNSFVGFIRDEYTTLPEDGNRPLFVYLNISWQYENTNDSYASDPARY VAAEQVRDLASTVFHELETPSIQNLIYHIGCRILARFPQLTDVSFQSQNHTWDTVVEE IPGSKGKVYTEPRPPYGFQHFTVTREDAEKEKQKAAEKCRSLKA*" /label="pucL CDS" gene 2837242..2838726 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /label="pucL gene" CDS 2838726..2839070 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /EC_number="3.5.2.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 16098976, 16782815, 21795808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 16098976, 16782815, 21795808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-hydroxyisourate hydrolase; also uricase subunit" /protein_id="NP_391126.2" /db_xref="EnsemblGenomes-Gn:BSU32460" /db_xref="EnsemblGenomes-Tr:CAB15236" /db_xref="GOA:O32142" /db_xref="InterPro:IPR000895" /db_xref="InterPro:IPR014306" /db_xref="InterPro:IPR023416" /db_xref="InterPro:IPR023418" /db_xref="InterPro:IPR023419" /db_xref="InterPro:IPR036817" /db_xref="PDB:2H0E" /db_xref="PDB:2H0F" /db_xref="PDB:2H0J" /db_xref="SubtiList:BG13987" /db_xref="UniProtKB/Swiss-Prot:O32142" /translation="MGKLTTHILDLTCGKPAANVKIGLKRLGESIMKEVYTNNDGRVD VPLLAGEELMSGEYVMEFHAGDYFASKNMNAADQPFLTIVTVRFQLADPDAHYHIPLL LSPFGYQVYRGS*" /label="pucM CDS" gene 2838726..2839070 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /label="pucM gene" promotor_-35 2838792..2838795 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2838813..2838832 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2838825 /Source="Nicolas_upshifts" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2839045 /Source="Nicolas_upshifts" /id="D1684" /incds=0 /nref=3 /ntot=90 /MaxReadThrough="1.80149" /MaxDrop="3.57243" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2547" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2839086..2839473) /Source="Nicolas_S_feature" /locus_tag="new_3335006_3335393_c" /HighExp="BT, S8, T2.0H, LBGstat, Cold, Etha, Sw, T1.0H, T1.30H, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1251" promotor_-35 2839433..2839442 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2839455..2839474 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2839458 /Source="Nicolas_upshifts" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="upshifts" ncRNA complement(2839494..2839625) /ncRNA_class="antisense_RNA" /gene="auzJ" /locus_tag="BSU_ncRNA_2" /product="putative antisense RNA for type I YuzJ toxin" /note="Evidence 3: Putative function from multiple computational evidences" /label="auzJ ncRNA" CDS 2839494..2839625 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 20525796, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097780.1" /db_xref="EnsemblGenomes-Gn:BSU32469" /db_xref="EnsemblGenomes-Tr:CAX52686" /db_xref="GOA:C0H3Q7" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Q7" /translation="MGFYNSGGYSGNSGYSNGFGSSFALIVVLFILLIIVGAAIFNY* " /label="yuzJ CDS" gene 2839494..2839625 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /label="yuzJ gene" gene complement(2839494..2839625) /gene="auzJ" /locus_tag="BSU_ncRNA_2" /label="auzJ gene" S_feature 2839626..2839694 /Source="Nicolas_S_feature" /locus_tag="new_3335546_3335614" /HighExp="BT, B36, S8, G/S, B60, Pyr, Glucon, C30, S7, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1252" downshifts 2839661 /Source="Nicolas_upshifts" /id="D1685" /incds=0 /nref=10 /ntot=25 /MaxReadThrough="0.61379" /MaxDrop="6.43101" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2548" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2839831..2840352) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, iron-sulfur subunit" /protein_id="NP_391127.1" /db_xref="EnsemblGenomes-Gn:BSU32470" /db_xref="EnsemblGenomes-Tr:CAB15237" /db_xref="GOA:O32143" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR002888" /db_xref="InterPro:IPR006058" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017611" /db_xref="InterPro:IPR036010" /db_xref="InterPro:IPR036884" /db_xref="SubtiList:BG13988" /db_xref="UniProtKB/Swiss-Prot:O32143" /translation="MDIKEAGPFPVKKEQFRMTVNGQAWEVAAVPTTHLSDLLRKEFQ LTGTKVSCGIGRCGACSILIDGKLANACMTMAYQADGHSITTIEGLQKEELDMCQTAF LEEGGFQCGYCTPGMIIALKALFRETPQPSDKDIEEGLAGNLCRCTGYGGIMRSACRI RRELNGGRRESGF*" /label="pucE CDS" gene complement(2839831..2840352) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /label="pucE gene" CDS complement(2840343..2842580) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, substrate and molybdenumcofactor subunit" /protein_id="NP_391128.1" /db_xref="EnsemblGenomes-Gn:BSU32480" /db_xref="EnsemblGenomes-Tr:CAB15238" /db_xref="GOA:O32144" /db_xref="InterPro:IPR000674" /db_xref="InterPro:IPR008274" /db_xref="InterPro:IPR017609" /db_xref="InterPro:IPR036856" /db_xref="InterPro:IPR037165" /db_xref="SubtiList:BG13989" /db_xref="UniProtKB/Swiss-Prot:O32144" /translation="MIINKPSRVRPDGRGKVTGELKYMTDLSFPGMLYGKVLRSAYPH AEIVSVCTIKAEKMEGVQAVVTHKDVPGLNRFGIVIPDQPVLCEDRVRYVGDAIAAVA AETEEIAEAALELIQVEYKELEVMDSPEKALRPNAQRLHEDGNILHRAFFSNGDVEEG FQASDTVFEETYELPRQMHTYMETEGGVAVPEDDGGFTMYAGTQHGYKDRFQLARIFD IPEEKIRIVSSPMGGSFGGKDELNIQPYAALLALKSGRPVKIHQTRKESVRSGIKRHP MKITIKTGADHSGNLLAHDVKIVADTGAYATLGPAVLDFSVEHAAGPYRIPNIRTEGI SVFTNNGVAGEFRGFGGNQITFALETHLDRLSGMLGIDPLELRRKNIRKPHDLGPLEH RIAPTDGAAQVLNAISKSPILKKTSRNCGYLQRGTGAAITMHGGGLGFGRMDAAGGRL SLSSEGKITASFGFEECGQGILAAIEQIVMEELGCAAEDISIVIGDTAKVPKSGSSTA SRGTSMVWHAIQRLKKPFLAQLKKRAAEWSGCSAENLIPGAAGLRDKNTKALVVTYKE LAEKGPLAEETAFDFPTTPDPVVGGHFLYSFGAAAVEVEVDLLTGDVKLIDCEHAIAA GPVVSPQGYRGQIEGGAAMALGYTLMEEAKMTDGRYAAENLDHYLIPGIKDVPDMKLI AIEDLMKGDVYGPRGVGEIGTIAITPAIVKAVHDAVGCWINKLPISREELLEAIDRKG LKQWT*" /label="pucD CDS" gene complement(2840343..2842580) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /label="pucD gene" CDS complement(2842581..2843414) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, FAD-binding subunit" /protein_id="NP_391129.1" /db_xref="EnsemblGenomes-Gn:BSU32490" /db_xref="EnsemblGenomes-Tr:CAB15239" /db_xref="GOA:O32145" /db_xref="InterPro:IPR002346" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR017612" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036683" /db_xref="SubtiList:BG13990" /db_xref="UniProtKB/Swiss-Prot:O32145" /translation="MNGQVTKARMNIQLWRPAALDEAYSLLEKLAPDVCAASGSTLLQ LQWDKGTLPKQHLVSLEGIDEMRGISTSDTHVSIGGLTSLNECRKNPLIKRALSCFSD AASAVAAPGIRSRATIGGNIASKIGDFIPLLLVLGAELIVYQKELIRLPLGAWLSEED FRTAIVTRVIIPRAEGERVFYHKLGRRQAFTGAAAVAAGRFLKDGSIRLAAGHADITP RRLLDSEAKWMAPGWDPHELYKTLIHELPFSSDVFMSAAYRKKAAANVIMAELMAEGG E*" /label="pucC CDS" gene complement(2842581..2843414) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /label="pucC gene" CDS complement(2843411..2844028) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /EC_number="2.7.7.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11344136, 21528011; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin cofactor synthesis cytidylyl transferase" /protein_id="NP_391130.2" /db_xref="EnsemblGenomes-Gn:BSU32500" /db_xref="EnsemblGenomes-Tr:CAB15240" /db_xref="GOA:O32146" /db_xref="InterPro:IPR017615" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13991" /db_xref="UniProtKB/Swiss-Prot:O32146" /translation="MRSPYLIGVFLAAGKSRRMGQNKLALPLKGENIGSLSLKTALSS RLDHVLVVERTEHASLEWIGAPYHAPPFQKRWSLHVCQDAEKGQGHSVSSGVRKAESM GADGIVILLADQPQLSVDHLNALVALAPESFAVSSFLGAFTPPIYFSSTCFPYVKGLK GDEGARRLLKSGQLGAGAVLEAKDSGELDDIDTPEEYDMVRRAMS*" /label="pucB CDS" gene complement(2843411..2844028) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /label="pucB gene" downshifts complement(2843520) /Source="Nicolas_upshifts" /id="D1686" /incds=1 /nref=3 /ntot=13 /MaxReadThrough="5.34639" /MaxDrop="3.22355" /score="-4.87239629" /energy="-9.9" /TU="U2549" /idTUdmin="U2549" /TUdmin="-3827" /isTUend="FALSE" /label="downshifts" CDS complement(2844025..2845017) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10217763, 11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217763, 11344136, 12029039; Product type f: factor" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase molybdopterin recruitmentfactor" /protein_id="NP_391131.1" /db_xref="EnsemblGenomes-Gn:BSU32510" /db_xref="EnsemblGenomes-Tr:CAB15241" /db_xref="GOA:O32147" /db_xref="InterPro:IPR003777" /db_xref="InterPro:IPR027051" /db_xref="SubtiList:BG13992" /db_xref="UniProtKB/Swiss-Prot:O32147" /translation="MGNFHTMLDALLEDQEEAVLATIVQVEGSAYRKAGASMLFKKKG RRIGLLSGGCVEEDVFQRISALGDQLTSTLIPYDMRSEDDLSWGMGAGCNGIIHVHAE RITQEKRRHYEKVRDCLHSGKAVTSVIKIESSHYLFLTENGHFGNWPDAPLQDIQRTV STLHLPHFDQTTNMFIQRIEPKPRLILFGAGPDNVPLANLAADTGFSVIVTDWRPAYC TSSLFPKADQLITAFPEQMLSEFQFFPHDAAVVATHHYQHDQTIINFLFSQNLHYIGL LGSANRTKRLLSGKHPPSHFYSPVGLKIGAEGPEEIAVSVVAEIIQTRKRVAVV*" /label="pucA CDS" gene complement(2844025..2845017) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /label="pucA gene" S_feature complement(2845018..2845104) /Source="Nicolas_S_feature" /locus_tag="new_3340938_3341024_c" /HighExp="BT, Cold, Sw, T-1.10H, S1, C30, S0, T-0.40H, T-3.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.607" /TUlongSig="NA" /TUlongPSig="NA" /label="S1253" promotor_-10 complement(2845082..2845101) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2845104) /Source="Nicolas_upshifts" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2845115..2845120) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2845246..2846496) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 20852637, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 20852637, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(S)-ureidoglycine-glyoxylate aminotransferase (PLP-dependent)" /protein_id="NP_391132.1" /db_xref="EnsemblGenomes-Gn:BSU32520" /db_xref="EnsemblGenomes-Tr:CAB15242" /db_xref="GOA:O32148" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR024169" /db_xref="PDB:3ISL" /db_xref="SubtiList:BG13993" /db_xref="UniProtKB/Swiss-Prot:O32148" /translation="MSGRRELCTPLRTIMTPGPVEVDPRVLRVMSTPVVGQFDPAFTG IMNETMEMLRELFQTKNRWAYPIDGTSRAGIEAVLASVIEPEDDVLIPIYGRFGYLLT EIAERYGANVHMLECEWGTVFDPEDIIREIKKVKPKIVAMVHGETSTGRIHPLKAIGE ACRTEDALFIVDAVATIGGCEVKVDEWKIDAAIGGTQKCLSVPSGMAPITYNERVADV IAARKKVERGIATQADRAALSGNRPITSNYFDLSQLEDYWSERRLNHHTEATTMLYAL REGVRLVLEEGLETRFERHRHHEAALAAGIKAMGLRLFGDDSCKMPVVTCVEIPGGID GESVRDMLLAQFGIEIASSFGPLAGKIWRIGTMGYSCRKENVLFVLAGLEAVLLRHNA GIEAGKALQAALDVYENAGRQAAV*" /label="pucG CDS" gene complement(2845246..2846496) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /label="pucG gene" CDS complement(2846513..2847751) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /EC_number="3.5.3.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11344136, 17362992, 25020232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoate amidohydrolase" /protein_id="NP_391133.1" /db_xref="EnsemblGenomes-Gn:BSU32530" /db_xref="EnsemblGenomes-Tr:CAB15243" /db_xref="GOA:O32149" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010158" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13994" /db_xref="UniProtKB/Swiss-Prot:O32149" /translation="MEKQKLSVKNSITDYIEWLAQYGASADGGVTRLLYTKEWMDAQL AVKTEMSSFGLETRFDDVGNVFGRLSGTQSPDEVIVTGSHIDTVINGGKYDGAYGVLA AMLALKQLKETYGAPKKTLEAVSLCEEEGSRFPMTYWGSGNMTGVFSEQDAKEPRDES GVSLQTAMHESGFGKGVFQSAYRTDISAFVELHIEQGKTLEMSGRDLGIVTSIAGQRR YLVTLEGECNHAGTTSMKWRKDPLAASSRIIHELLLRSDELPDELRLTCGKITAEPNV ANVIPGRVQFSIDIRHQHQHVLEQFHQDMVALINGICLQKGIRAVIDEYMRIEPVPMD ERLKAAAFETALENGFSCEEMVSGAGHDAQMIGRRYPACMLFVPSRGGVSHSPKEYTS ARQLEIGVRALTDLLYKLAY*" /label="pucF CDS" gene complement(2846513..2847751) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /label="pucF gene" CDS 2847974..2848111 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514002.1" /translation="MNKLSWRGDVRGTDENRNAGSPQKQDLKIWKQEISASSKGTNLQ F*" /label="hypothetical protein CDS" gene 2847974..2848111 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /label="gene" promotor_-35 2848133..2848136 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2848151..2848170 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2848152 /Source="Nicolas_upshifts" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="upshifts" CDS 2848193..2849059 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1396690, 12490701, 12883447, 16291680, 25844442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1396690, 12490701, 12883447, 16291680, 25844442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular ribonuclease" /protein_id="NP_391134.1" /db_xref="EnsemblGenomes-Gn:BSU32540" /db_xref="EnsemblGenomes-Tr:CAB15244" /db_xref="GOA:O32150" /db_xref="InterPro:IPR007346" /db_xref="SubtiList:BG13995" /db_xref="UniProtKB/Swiss-Prot:O32150" /translation="MTKKAWFLPLVCVLLISGWLAPAASASAQTTLSLNDRLASSPSG TGSLLSLAAPAAPYADTDTYYEGAEGKTGDSLKSTLHRIISGHTMLSYSEVWNALKET DEDPRNPNNVILLYTNESRSKNLNGGNVGDWNREHVWAKSHGDFGTSKGPGTDIHHLR PADVQVNSARGNMDFDNGGTEYAKAPGNYYDGDSWEPRDDVKGDVARMLFYMAVRYEG DDGYPDLELNDKTGNGSAPYHGKQSVLLEWNKQDPVDDRERKRNEIIYEKYQHNRNPF IDHPEWADEIWP*" /label="bsnA CDS" gene 2848193..2849059 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /label="bsnA gene" downshifts 2849062 /Source="Nicolas_upshifts" /id="D1687" /incds=0 /nref=48 /ntot=190 /MaxReadThrough="0.45317" /MaxDrop="6.90997" /score="25.7790712" /energy="-15.5" /TU="NA" /idTUdmin="U2550" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(2849093..2850196) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23175651, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23175651, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid ABC transporter (ATP-bindingsubunit)" /protein_id="NP_391135.1" /db_xref="EnsemblGenomes-Gn:BSU32550" /db_xref="EnsemblGenomes-Tr:CAB15245" /db_xref="GOA:O32151" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR013611" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13996" /db_xref="UniProtKB/Swiss-Prot:O32151" /translation="MASLTFEHVKKSYHSQLTVKDFDLDVKDKELLVLVGPSGCGKST TLRMVAGLESISEGNLLIDGERVNDLPPKERDIAMVFQNYALYPHMTVFDNMAFGLKL RKMAKQEIAERVHAAARILEIEHLLKRKPKALSGGQRQRVALGRSIVREPKVFLMDEP LSNLDAKLRVTMRTEISKLHQRLEATIIYVTHDQTEAMTMGDRIVVMNEGEIQQVAKP HDIYHYPANLFVAGFIGSPGMNFLKGIIEQQHGELFFTNSSIRLHIPEEKAKRLKEKG YAGEQMIAGVRPEHITQMTGNDQLFDSVFQANVEVNENLGSELIVHVMAGDERLKVRL DGNTRIDAGDSIQLSVKMDHVVFFDAETEEAVY*" /label="frlP CDS" gene complement(2849093..2850196) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /label="frlP gene" downshifts complement(2849108) /Source="Nicolas_upshifts" /id="D1688" /incds=0 /nref=57 /ntot=215 /MaxReadThrough="3.04361" /MaxDrop="6.06171" /score="29.1144499" /energy="-15.5" /TU="NA" /idTUdmin="U2553" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2850197..2851130) /Source="Nicolas_S_feature" /locus_tag="new_3346117_3347050_c" /HighExp="HiOs, T-5.40H, T5.0H, GM-0.1, S2, GM-0.2, GM 5, T-4.40H, T4.0H, SMM" /AntisenseName="frlR" /AntisenseCor="0.22682293682100099" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.971, 0.456, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1254" promotor_-35 2850234..2850241 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2850255..2850274 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2850265 /Source="Nicolas_upshifts" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2850316..2850322 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2850333 /Source="Nicolas_upshifts" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2850337..2850356 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2850378..2851106 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /experiment="publication(s) with functional evidences, PMID:21347729, 21398478, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21347729, 21398478, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FrlR transcriptional regulator (GntR family)" /protein_id="NP_391136.3" /db_xref="EnsemblGenomes-Gn:BSU32560" /db_xref="EnsemblGenomes-Tr:CAB15246" /db_xref="GOA:O32152" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2IKK" /db_xref="SubtiList:BG13997" /db_xref="UniProtKB/Swiss-Prot:O32152" /translation="MLNNGSSTPLYIQLKQIITDDIKKGVYSPTAKLPTENELCTKYN VSRITVRKAILDLVEEGYLIRQQGKGTFVKSPKLKRELIAVNGYSEFMESTGKKPKHH VLSHDIIPASKPIAEKLQIQPESPVVELKRILYNDDQPLTFEVTHYPLDLFPGIDTFI ADGVSMHDILKQQYKVVPTHNTKLLNVVYAQQEESKYLDCDIGDALFEIDKTAFTSND QPIYCSLFLMHTNRVTFTINSPYT*" /label="frlR CDS" gene 2850378..2851106 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /label="frlR gene" CDS complement(2851131..2851985) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 14641112, 15556630, 16153181, 21347729, 21398478, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fructoselysine kinase" /protein_id="NP_391137.1" /db_xref="EnsemblGenomes-Gn:BSU32570" /db_xref="EnsemblGenomes-Tr:CAB15247" /db_xref="GOA:O32153" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13998" /db_xref="UniProtKB/Swiss-Prot:O32153" /translation="MKLIAVGDNVVDYYQDQETFYPGGNALNVAVLAKRLGHESSYIG IVGNDEAAAHLLNVLKLEQVNADYIRQAHGENGMAIVTLDEQGDRIFVRSNKGGIQSR LRLAFQEKDVSFISGHDLLHTSVYSRLENDLPQLCGLVPVSFDFSTNREDDYLRRVCP YVTYAFFSGSDLSESECGELAKTAHGYGAKMVCMTRGGQGAILSAGDRVYHQPIVEAD IIDTLGAGDSFIAGFLTAFCVKQDITYALRQAAETAAKTCGVYGAFGYGYPYRLEDGG SSEKTRIL*" /label="frlD CDS" gene complement(2851131..2851985) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /label="frlD gene" misc_feature complement(2851318..2851337) /Source="Nicolas_upshift_promotors" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2851330) /Source="Nicolas_upshifts" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(2851488..2851588) /Source="Nicolas_upshift_promotors" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2851528) /Source="Nicolas_upshifts" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2851999..2852901) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391138.1" /db_xref="EnsemblGenomes-Gn:BSU32580" /db_xref="EnsemblGenomes-Tr:CAB15248" /db_xref="GOA:O32154" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13999" /db_xref="UniProtKB/Swiss-Prot:O32154" /translation="MLPQKKTDSFRLEPVPDQHIEVKDKPRRKWYIGETSVWVFLFLY LIAIAYPLLWMVMSAFKNSDDIFEHSWSLPSSWHPENFVSAWNQGISSYFMNSVIVTA LTCVITVFISAWAAYGLSRFEFKGKGFFLVLCLGGLMLTPQVSLVPLYSIIQSLGLYN TYWALILPYAAYRIPFTIILIRSYFLSISKELEEAAYLDGCTSFGVFFRIFLPMSVPI LVTSGILTAYHTWNEFMFAIIFIDDENLRTIPAGLMQFRDALQTDWGVLLAGLTISAA PIIILFLLMQKYFVRGIASGSVKG*" /label="frlM CDS" gene complement(2851999..2852901) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /label="frlM gene" CDS complement(2852905..2853783) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391139.1" /db_xref="EnsemblGenomes-Gn:BSU32590" /db_xref="EnsemblGenomes-Tr:CAB15249" /db_xref="GOA:O32155" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14000" /db_xref="UniProtKB/Swiss-Prot:O32155" /translation="MVNQNKIIPYLFLVPALVFLLFVYIPIFENVFLSLFQWSSFSPE KTFIGLKNYVELFHDPVFYQALTNNVLYAVISIVCQVFGGLILAAVLEDKLVRKWSPF FRTVFFLPVVISMTVIALLFDFIYNPETGLLNQLLQAIGLDQLTRAWLGDDSTAMLSV IFVSQWQSVGYIAMLYIVSIQKIPDELYEAARLDGAGKIQQFFHITVPQTKEMSFVAV VMTLTGAFTVFNEPYILTGGGPGKASEVLSTFLYKSAFTKDMMGYASAIATVVLIITL ALSLMQMKFFKTGKEE*" /label="frlN CDS" gene complement(2852905..2853783) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /label="frlN gene" CDS complement(2853841..2855109) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 21347729; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose amino acid-binding lipoprotein" /protein_id="NP_391140.1" /db_xref="EnsemblGenomes-Gn:BSU32600" /db_xref="EnsemblGenomes-Tr:CAB15250" /db_xref="GOA:O32156" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG14001" /db_xref="UniProtKB/Swiss-Prot:O32156" /translation="MKKMLLFLIIAAVSMLTIAGCSSQSSSADGKVTLKFFHRWPKEP EKSYFEEVVKEFEKDHPDIDIQIEAVLNDSYKDKIKVMLGTTSPPDIYFSWSDEFAFK FIRGNKALDLSSYYKNDTDWSSQLVQSQITPFTYENKQYGVPWQMDAKSFFYNKDIFQ KLNLDPPKTWDELIDVSKKLKEHGYTPISFGTKATWTISHYIGTLNQRMVDEKTREKD YNAKTGEFTDEGYVKALEKLQELMPYFNKHVNSVDHEYVRQQFKSGKSAMIYAETAEI KLVEPVNLGMFPFPEISGQKGSSEALTGAPEGFMISSRTKHPKEAMEFLQFLTSKRMG EKLVKDVGKYSAVQGTATEENATAIQREAVQHIVDAKSMVPWFDMDVDVEVADAYLTG VQQMLGGDMTPQQVMKAVQKAAKQVRASAE*" /label="frlO CDS" gene complement(2853841..2855109) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /label="frlO gene" promotor_no_box 2855000..2855100 /Source="Nicolas_upshift_promotors" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2855060 /Source="Nicolas_upshifts" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2855180) /Source="Nicolas_upshifts" /id="D1689" /incds=0 /nref=21 /ntot=141 /MaxReadThrough="7.96763" /MaxDrop="4.994" /score="3.53212058" /energy="-13.8" /TU="U2557" /idTUdmin="U2558" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS complement(2855190..2856176) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12618455, 15556630, 16153181, 18083814, 21347729, 21398478, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructosamine-6-P deglycase" /protein_id="NP_391141.1" /db_xref="EnsemblGenomes-Gn:BSU32610" /db_xref="EnsemblGenomes-Tr:CAB15251" /db_xref="GOA:O32157" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR024713" /db_xref="InterPro:IPR035488" /db_xref="InterPro:IPR035490" /db_xref="PDB:3EUA" /db_xref="SubtiList:BG14002" /db_xref="UniProtKB/Swiss-Prot:O32157" /translation="MSQATAKVNREVQAFLQDLKGKTIDHVFFVACGGSSAIMYPSKY VFDRESKSINSDLYSANEFIQRNPVQLGEKSLVILCSHSGNTPETVKAAAFARGKGAL TIAMTFKPESPLAQEAQYVAQYDWGDEALAINTNYGVLYQIVFGTLQVLENNTKFEQA IEGLDQLQAVYEKALKQEADNAKQFAKAHEKESIIYTMASGANYGVAYSYSICILMEM QWIHSHAIHAGEYFHGPFEIIDESVPFIILLGLDETRPLEERALTFSKKYGKKLTVLD AASYDFTAIDDSVKGYLAPLVLNRVLRSYADELAEERNHPLSHRRYMWKVEY*" /label="frlB CDS" gene complement(2855190..2856176) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /label="frlB gene" upshifts 2856123 /Source="Nicolas_upshifts" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2856126..2856130 /Source="Nicolas_upshift_promotors" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2856219..2856238) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2856232) /Source="Nicolas_upshifts" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2856253..2856260) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2856390) /Source="Nicolas_upshifts" /id="D1690" /incds=0 /nref=116 /ntot=274 /MaxReadThrough="0.87627" /MaxDrop="5.35981" /score="3.53212058" /energy="-13.8" /TU="NA" /idTUdmin="U2558" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2856392..2856766) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excinuclease" /protein_id="NP_391142.1" /db_xref="EnsemblGenomes-Gn:BSU32620" /db_xref="EnsemblGenomes-Tr:CAB15252" /db_xref="GOA:O32158" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR014527" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG14003" /db_xref="UniProtKB/Swiss-Prot:O32158" /translation="MIKIDIPAPNVTITERQQSANDNEPKIKPIHGFIDFHQIPRDKG GIFMFYNIHDELLFVGKARKLRQRIKKHFEDTVSPIKHHRDEVYKIEVCVVDDPMERE IYETYIINTQHSKYNIDKVFFK*" /label="yurQ CDS" gene complement(2856392..2856766) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /label="yurQ gene" upshifts complement(2856830) /Source="Nicolas_upshifts" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2856837..2856848) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2856862..2856868) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2856869..2857987) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 13914427, 16245349, 22271930, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acid oxidase" /protein_id="NP_391143.1" /db_xref="EnsemblGenomes-Gn:BSU32630" /db_xref="EnsemblGenomes-Tr:CAB15253" /db_xref="GOA:O32159" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14004" /db_xref="UniProtKB/Swiss-Prot:O32159" /translation="MKSYIIVGAGILGASTAYHLAKTGARVTVIDRKEPGQATDAAAG IVCPWLSQRRNQDWYQLAKGGARYYKDLIHQLEKDGESDTGYKRVGAISIHTDASKLD KMEERAYKRREDAPEIGDITRLSASETKKLFPILADGYESVHISGAARVNGRALCRSL LSAAEKRGATVIKGNASLLFENGTVTGVQTDTKQFAADAVIVTAGAWANEILKPLGIH FQVSFQKAQIMHFEMTDADTGSWPVVMPPSDQYILSFDNGRIVAGATHENDAGLDDLR VTAGGQHEVLSKALAVAPGLADAAAVETRVGFRPFTPGFLPVVGAVPNVQGLYAANGL GASGLTMGPFLGAELAKLVLGKQTELDLSPYDPAGALA*" /label="dadA CDS" gene complement(2856869..2857987) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /label="dadA gene" promotor_-10 complement(2858012..2858031) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2858018) /Source="Nicolas_upshifts" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2858020..2858630) /Source="Nicolas_S_feature" /locus_tag="new_3353940_3354550_c" /HighExp="G135, H2O2, G180, Paraq, G150, Oxctl, LBGexp, Salt, dia15, Diami" /AntisenseName="yurS" /AntisenseCor="-0.14245591415946501" /AntisenseRegPval="-1.7" /CDS_PredictionProba="0.95340499999999995" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1255" promotor_-35 complement(2858045..2858051) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2858084..2858093 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2858107..2858126 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2858111 /Source="Nicolas_upshifts" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2858124..2858139) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2858128) /Source="Nicolas_upshifts" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2858146..2858150) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2858146..2858292 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type f : factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054592.1" /db_xref="EnsemblGenomes-Gn:BSU32640" /db_xref="EnsemblGenomes-Tr:CAE01466" /db_xref="GOA:Q7WY59" /db_xref="SubtiList:BG14173" /db_xref="UniProtKB/Swiss-Prot:Q7WY59" /translation="MSENRHENEENRRDAAVAKVQNSGNAKVVVSVNTDQDQAQAQSQ DGED*" /label="sspG CDS" gene 2858146..2858292 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /label="sspG gene" CDS 2858292..2858567 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9852018" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391144.1" /db_xref="EnsemblGenomes-Gn:BSU32650" /db_xref="EnsemblGenomes-Tr:CAB15254" /db_xref="SubtiList:BG14005" /db_xref="UniProtKB/Swiss-Prot:O32160" /translation="MNENIIPLNRHTQEIPTTESVIKNSGNSEVHIDIHIDTMPIAFA ILCSALAAKQMTKEEFDMAYTQLREMNRENNSRSSVKQIINQETEEE*" /label="yurS CDS" gene 2858292..2858567 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /label="yurS gene" upshifts complement(2858436) /Source="Nicolas_upshifts" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2858452..2858466) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2858475..2858479) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2858547 /Source="Nicolas_upshifts" /id="D1691" /incds=0 /nref=36 /ntot=86 /MaxReadThrough="1.84089" /MaxDrop="7.4989" /score="15.0184762" /energy="-11" /TU="NA" /idTUdmin="U2560" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(2858631..2859014) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10882093, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10882093, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxalase; lactoylbacillithiol lyase" /protein_id="NP_391145.1" /db_xref="EnsemblGenomes-Gn:BSU32660" /db_xref="EnsemblGenomes-Tr:CAB15255" /db_xref="GOA:O32161" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG14006" /db_xref="UniProtKB/Swiss-Prot:O32161" /translation="MKIVVTSIFVQDQDMALEFYTEKLGFIKKEDVPMGKFRWITLVS PDDQDGTELLLEPNEHPAAKEYQKKIFSEGLPATMFGVADIQKEYNRLKEKGVTFTTE PTKMGEVTIAVFDDTCGNLIQIVQK*" /label="glxB CDS" gene complement(2858631..2859014) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /label="glxB gene" S_feature complement(2859015..2859124) /Source="Nicolas_S_feature" /locus_tag="new_3354935_3355044_c" /HighExp="Salt, G180, H2O2, Paraq, G135, G150, LBGexp, LBGstat, dia15, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1256" CDS complement(2859125..2859403) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097781.1" /db_xref="EnsemblGenomes-Gn:BSU32669" /db_xref="EnsemblGenomes-Tr:CAX52687" /db_xref="GOA:C0H3Q8" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Q8" /translation="MNGNKDAIFKALGDSTRRLILDELSERNELTLYELTIRLITKYD LSITRQAIAKHLSVLEDAGLVTSKRKGKYRVLIFNNEPLKNLLKGWIE*" /label="yuzN CDS" gene complement(2859125..2859403) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /label="yuzN gene" promotor_-10 complement(2859401..2859420) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2859425) /Source="Nicolas_upshifts" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2859435..2859442) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2859566..2859672) /Source="Nicolas_S_feature" /locus_tag="new_3355486_3355592_c" /HighExp="Sw, BI, LPhT, C90, BC, M0t45, Gly, Cold, H2O2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.994" /TUlongSig="SigGF" /TUlongPSig="0.999" /label="S1257" downshifts complement(2859609) /Source="Nicolas_upshifts" /id="D1692" /incds=0 /nref=189 /ntot=303 /MaxReadThrough="3.22318" /MaxDrop="7.82118" /score="0.760415296" /energy="-10.1" /TU="U2564" /idTUdmin="U2565" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2859673..2861070) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16109955, 16431905, 16621837, 20097860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16109955, 16431905, 16621837, 20097860; Product type f: factor" /codon_start=1 /transl_table=11 /product="FeS cluster formation scaffold protein" /protein_id="NP_391146.1" /db_xref="EnsemblGenomes-Gn:BSU32670" /db_xref="EnsemblGenomes-Tr:CAB15256" /db_xref="GOA:O32162" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR010231" /db_xref="SubtiList:BG14007" /db_xref="UniProtKB/Swiss-Prot:O32162" /translation="MAKKMPDIGEYKYGFHDKDVSIFRSERGLTKEIVEEISRMKEEP QWMLDFRLKSLEHFYNMPMPQWGGDLNSLNFDEITYYVKPSERSERSWDEVPEEIKQT FDKLGIPEAEQKYLAGVSAQYESEVVYHNMKEDLEAQGIVFKDTDSALKENEDIFREH WAKVIPPTDNKFAALNSAVWSGGSFIYVPKGVKVETPLQAYFRINSENMGQFERTLII VDEEASVHYVEGCTAPVYTTNSLHSAVVEIIVKKGGYCRYTTIQNWANNVYNLVTKRT VCEENATMEWIDGNIGSKLTMKYPACILKGEGARGMTLSIALAGKGQHQDAGAKMIHL APNTSSTIVSKSISKQGGKVTYRGIVHFGRKAEGARSNIECDTLIMDNKSTSDTIPYN EILNDNISLEHEAKVSKVSEEQLFYLMSRGISEEEATEMIVMGFIEPFTKELPMEYAV EMNRLIKFEMEGSIG*" /label="sufB CDS" gene complement(2859673..2861070) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /label="sufB gene" downshifts 2860868 /Source="Nicolas_upshifts" /id="D1693" /incds=1 /nref=1 /ntot=150 /MaxReadThrough="2.66718" /MaxDrop="3.75483" /score="-4.89805724" /energy="-5" /TU="NA" /idTUdmin="U2560" /TUdmin=2310 /isTUend="FALSE" /label="downshifts" CDS complement(2861091..2861534) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16877383, 20097860, 21236255, 24321018, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16877383, 20097860, 21236255, 24321018, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="iron-sulfur cluster assembly sulfur-transfer protein (Zn(2+)-dependent)" /protein_id="NP_391147.1" /db_xref="EnsemblGenomes-Gn:BSU32680" /db_xref="EnsemblGenomes-Tr:CAB15257" /db_xref="GOA:O32163" /db_xref="InterPro:IPR002871" /db_xref="PDB:1XJS" /db_xref="PDB:2AZH" /db_xref="SubtiList:BG14008" /db_xref="UniProtKB/Swiss-Prot:O32163" /translation="MSFNANLDTLYRQVIMDHYKNPRNKGVLNDSIVVDMNNPTCGDR IRLTMKLDGDIVEDAKFEGEGCSISMASASMMTQAIKGKDIETALSMSKIFSDMMQGK EYDDSIDLGDIEALQGVSKFPARIKCATLSWKALEKGVAKEEGGN*" /label="sufU CDS" gene complement(2861091..2861534) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /label="sufU gene" CDS complement(2861524..2862744) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_391148.1" /db_xref="EnsemblGenomes-Gn:BSU32690" /db_xref="EnsemblGenomes-Tr:CAB15258" /db_xref="GOA:O32164" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR010970" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="PDB:5J8Q" /db_xref="SubtiList:BG14009" /db_xref="UniProtKB/Swiss-Prot:O32164" /translation="MNITDIREQFPILHQQVNGHDLVYLDSAATSQKPRAVIETLDKY YNQYNSNVHRGVHTLGTRATDGYEGAREKVRKFINAKSMAEIIFTKGTTTSLNMVALS YARANLKPGDEVVITYMEHHANIIPWQQAVKATGATLKYIPLQEDGTISLEDVRETVT SNTKIVAVSHVSNVLGTVNPIKEMAKIAHDNGAVIVVDGAQSTPHMKIDVQDLDCDFF ALSSHKMCGPTGVGVLYGKKALLENMEPAEFGGEMIDFVGLYESTWKELPWKFEAGTP IIAGAIGLGAAIDFLEEIGLDEISRHEHKLAAYALERFRQLDGVTVYGPEERAGLVTF NLDDVHPHDVATVLDAEGIAVRAGHHCAQPLMKWLDVTATARASFYLYNTEEEIDKLV EALQKTKEYFTNVF*" /label="sufS CDS" gene complement(2861524..2862744) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /label="sufS gene" CDS complement(2862744..2864057) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16109955, 16431905, 16621837, 19187533, 20097860, 28839209; Product type f: factor" /codon_start=1 /transl_table=11 /product="Fe-S cluster assembly protein SufD" /protein_id="NP_391149.1" /db_xref="EnsemblGenomes-Gn:BSU32700" /db_xref="EnsemblGenomes-Tr:CAB15259" /db_xref="GOA:O32165" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR011542" /db_xref="SubtiList:BG14010" /db_xref="UniProtKB/Swiss-Prot:O32165" /translation="MTLGTKLSVDQEYLKSFSEKHQEPAWLKNLRLQALEQAEDLPMP KPDKTKITNWNFTNFAKHTVDNEPLSSLEDLTDEVKALIDIENEDKTLYVQRDQTPAH LSLSQELKDKGVIFTDILTAAREHSDLVEKYFMKDGVKVDEHKLTALHAALVNGGAFL YVPKNVQVETPVQAVYVHESNDTALFNHVLIVAEDHSSVTYVENYISTVNPKDAVFNI ISEVITGDNASVTYGAVDNLSSGVTTYVNRRGAARGRDSKIEWALGLMNDGDTISENT TNLYGDGTYGDTKTVVVGRGEQTENFTTQIIHFGKASEGYILKHGVMKDSASSIFNGI GKIEHGASKANAEQESRVLMLSEKARGDANPILLIDEDDVTAGHAASVGRVDPIQLYY LMSRGIPKEEAERLVIYGFLAPVVNELPIEGVKKQLVSVIERKVK*" /label="sufD CDS" gene complement(2862744..2864057) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /label="sufD gene" CDS complement(2864075..2864860) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16431905, 20097860, 28839209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16431905, 20097860, 28839209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur mobilizing ABC protein, ATPase" /protein_id="NP_391150.1" /db_xref="EnsemblGenomes-Gn:BSU32710" /db_xref="EnsemblGenomes-Tr:CAB15260" /db_xref="GOA:P80866" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010230" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14011" /db_xref="UniProtKB/Swiss-Prot:P80866" /translation="MAASTLTIKDLHVEIEGKEILKGVNLEIKGGEFHAVMGPNGTGK STLSAAIMGHPKYEVTKGSITLDGKDVLEMEVDERAQAGLFLAMQYPSEISGVTNADF LRSAINARREEGDEISLMKFIRKMDENMEFLEMDPEMAQRYLNEGFSGGEKKRNEILQ LMMIEPKIAILDEIDSGLDIDALKVVSKGINKMRSENFGCLMITHYQRLLNYITPDVV HVMMQGRVVKSGGAELAQRLEAEGYDWIKQELGIEDETVGQEA*" /label="sufC CDS" gene complement(2864075..2864860) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /label="sufC gene" promotor_-10 complement(2864904..2864923) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(2864905) /Source="Nicolas_upshifts" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="upshifts" promotor_-35 complement(2864937..2864944) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" promotor_-10 complement(2864961..2864980) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(2864970) /Source="Nicolas_upshifts" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="upshifts" S_feature complement(2864972..2865053) /Source="Nicolas_S_feature" /locus_tag="new_3360892_3360973_c" /HighExp="Salt, HiOs, B60, LoTm, T1.0H, Gly, T2.0H, C30, Etha, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1258" promotor_-35 complement(2864996..2865000) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" misc_RNA complement(2865017..2865264) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /product="small regulatory RNA or messenger RNA" /experiment="publication(s) with functional evidences, PMID:18948176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176; Product type n: RNA" /label="bsrI RNA" gene complement(2865017..2865264) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /label="bsrI gene" CDS complement(2865054..2865191) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin antitoxin system" /protein_id="YP_003097782.1" /db_xref="EnsemblGenomes-Gn:BSU32719" /db_xref="EnsemblGenomes-Tr:CAX52688" /db_xref="UniProtKB/Swiss-Prot:C0H3Q9" /translation="MEKAMQLSHGIGYEEYGRRLETRMKVERQRELDYEKSKRISAGA Y*" /label="yuzK CDS" gene complement(2865054..2865191) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /label="yuzK gene" S_feature complement(2865192..2865276) /Source="Nicolas_S_feature" /locus_tag="new_3361112_3361196_c" /HighExp="HiOs, Salt, B60, S5, T1.0H, S8, HiTm, S7, T1.30H, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63415999999999995" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1259" promotor_-10 complement(2865260..2865279) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2865276) /Source="Nicolas_upshifts" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2865278..2865384) /Source="Nicolas_S_feature" /locus_tag="new_3361198_3361304_c" /HighExp="S8, S5, S7, S6, S4, BT, ferm, nit, S3, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1260" promotor_-35 complement(2865295..2865298) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2865385..2865762) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391151.1" /db_xref="EnsemblGenomes-Gn:BSU32720" /db_xref="EnsemblGenomes-Tr:CAB15261" /db_xref="GOA:O32166" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG14012" /db_xref="UniProtKB/Swiss-Prot:O32166" /translation="MEGFSLNQDRGSMQDALKQYKHGLGTFEQKMPLMGRKFNEFTEQ CFAGNSLTEREKQLIALGIAINAQDEYCMIYHTKGCLDQGASEENILEAVSVAAAFGG GAAFSQGVTVVQQCIEEFGNTTH*" /label="yurZ CDS" gene complement(2865385..2865762) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /label="yurZ gene" promotor_-10 complement(2865779..2865790) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-10" upshifts complement(2865785) /Source="Nicolas_upshifts" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="upshifts" promotor_-35 complement(2865804..2865810) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-35" CDS complement(2865847..2866671) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 16109943, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 16109943, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, substrate binding lipoprotein" /protein_id="NP_391152.1" /db_xref="EnsemblGenomes-Gn:BSU32730" /db_xref="EnsemblGenomes-Tr:CAB15262" /db_xref="GOA:O32167" /db_xref="InterPro:IPR004872" /db_xref="PDB:4GOT" /db_xref="SubtiList:BG14013" /db_xref="UniProtKB/Swiss-Prot:O32167" /translation="MKKLFLGALLLVFAGVMAACGSNNGAESGKKEIVVAATKTPHAE ILKEAEPLLKEKGYTLKVKVLSDYKMYNKALADKEVDANYFQHIPYLEQEMKENTDYK LVNAGAVHLEPFGIYSKTYKSLKDLPDGATIILTNNVAEQGRMLAMLENAGLITLDSK VETVDATLKDIKKNPKNLEFKKVAPELTAKAYENKEGDAVFINVNYAIQNKLNPKKDA IEVESTKNNPYANIIAVRKGEEDSAKIKALMEVLHSKKIKDFIEKKYDGAVLPVSE*" /label="metQ CDS" gene complement(2865847..2866671) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /label="metQ gene" downshifts complement(2865855) /Source="Nicolas_upshifts" /id="D1694" /incds=0 /nref=167 /ntot=246 /MaxReadThrough="2.13581" /MaxDrop="6.33517" /score="28.8468637" /energy="-12.6" /TU="NA" /idTUdmin="U2569" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" downshifts complement(2866004) /Source="Nicolas_upshifts" /id="D1695" /incds=1 /nref=2 /ntot=171 /MaxReadThrough="6.93658" /MaxDrop="2.3341" /score="28.8468637" /energy="-12.6" /TU="U2569" /idTUdmin="U2569" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-35 2866031..2866036 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2866052..2866070 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2866054 /Source="Nicolas_upshifts" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2866685..2867353) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 15849754, 16850406, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 15849754, 16850406, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, permease component" /protein_id="NP_391153.1" /db_xref="EnsemblGenomes-Gn:BSU32740" /db_xref="EnsemblGenomes-Tr:CAB15263" /db_xref="GOA:O32168" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14014" /db_xref="UniProtKB/Swiss-Prot:O32168" /translation="MFEKYFPNVDLTELWNATYETLYMTLISLLFAFVIGVILGLLLF LTSKGSLWQNKAVNSVIAAVVNIFRSIPFLILIILLLGFTKFLVGTILGPNAALPALV IGSAPFYARLVEIALREVDKGVIEAAKSMGAKTSTIIFKVLIPESMPALISGITVTAI ALIGSTAIAGAIGSGGLGNLAYVEGYQSNNADVTFVATVFILIIVFIIQIIGDLITNI IDKR*" /label="metP CDS" gene complement(2866685..2867353) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /label="metP gene" CDS complement(2867346..2868371) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 17038623; Product type t: transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter (ATP-binding protein)" /protein_id="NP_391154.1" /db_xref="EnsemblGenomes-Gn:BSU32750" /db_xref="EnsemblGenomes-Tr:CAB15264" /db_xref="GOA:O32169" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017908" /db_xref="InterPro:IPR018449" /db_xref="InterPro:IPR026253" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14015" /db_xref="UniProtKB/Swiss-Prot:O32169" /translation="MINLQDVSKVYKSKHGDVNAVQNVSLSIKKGEIFGIIGYSGAGK SSLIRLLNGLEKPTSGTVEVAGTKINEVNGRGLRKARHEISMIFQHFNLLWSRTVRDN IMFPLEIAGVKKSERIKRANELIKLVGLEGKEKSYPSQLSGGQKQRVGIARALANNPK VLLCDEATSALDPQTTDSILDLLSDINERLGLTIVLITHEMHVIRKICNRVAVMENGK VVEEGEVLDVFKNPKEQMTKRFVQQVTEPEETKETLQHLLDDTASGKMVQLTFVGESA EQPLITEMIRNFNVSVNILQGKISQTKDGAYGSLFIHIDGDEEEVQNVIRFINDKQVK AEVITNV*" /label="metN CDS" gene complement(2867346..2868371) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /label="metN gene" S_feature complement(2868372..2868476) /Source="Nicolas_S_feature" /locus_tag="new_3364292_3364396_c" /HighExp="MG 5, MG t5, MG 10, BMM, MG-0.2, GM 25, MG-0.1, MG 15, M9-exp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1261" misc_RNA complement(2868477..2868583) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswH RNA" gene complement(2868477..2868583) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /label="mswH gene" downshifts 2868546 /Source="Nicolas_upshifts" /id="D1696" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="1.54417" /MaxDrop="5.51028" /score="-1.70178746" /energy="-11.2" /TU="NA" /idTUdmin="U2568" /TUdmin=2420 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2868610..2868629) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2868622) /Source="Nicolas_upshifts" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2868624..2868697) /Source="Nicolas_S_feature" /locus_tag="new_3364544_3364617_c" /HighExp="M9-stat, S2, LoTm, T5.0H, HiOs, B60, S3, T3.30H, LPhT, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1262" promotor_-35 complement(2868645..2868652) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2868698..2869042) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391155.1" /db_xref="EnsemblGenomes-Gn:BSU32760" /db_xref="EnsemblGenomes-Tr:CAB15265" /db_xref="InterPro:IPR003033" /db_xref="InterPro:IPR036527" /db_xref="SubtiList:BG14016" /db_xref="UniProtKB/Swiss-Prot:O32170" /translation="MEKAEVLEDEYQHLFLKPLLNASTLLITFQGEAEALTVSINEQG EMKKVSPPQTSNLTFYGNQTEIIDLLHGDISLQHLIQSGSLKVKGSFRALLKLEAILW LTNGFFQRILKN*" /label="yusD CDS" gene complement(2868698..2869042) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /label="yusD gene" S_feature complement(2869043..2869148) /Source="Nicolas_S_feature" /locus_tag="new_3364963_3365068_c" /HighExp="LPhT, HiOs, M9-stat, dia5, T2.0H, Diami, T1.30H, T0.30H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA, SigA" /TUshortPSig="1, 0.996, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S1263" CDS complement(2869149..2869469) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_391156.1" /db_xref="EnsemblGenomes-Gn:BSU32770" /db_xref="EnsemblGenomes-Tr:CAB15266" /db_xref="GOA:O32171" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14017" /db_xref="UniProtKB/Swiss-Prot:O32171" /translation="MKELQEHELDHIEDDVYLLYLYTPFCGTCQLASKMLTVVKEMLP DVAFYQNNVNYSPTFAKAYQIESVPCFLLFKGGKMVERGYAFHSVSYLYELIKQKSSS ASHL*" /label="yusE CDS" gene complement(2869149..2869469) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /label="yusE gene" CDS complement(2869471..2869911) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12794188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease" /protein_id="NP_391157.1" /db_xref="EnsemblGenomes-Gn:BSU32780" /db_xref="EnsemblGenomes-Tr:CAB15267" /db_xref="GOA:O32172" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG14018" /db_xref="UniProtKB/Swiss-Prot:O32172" /translation="MLAVNFTAFFYNLNISNLTRQVNKMKMDELEKVMIVEGKSDKEK IESVLNEPMRIICTNGTISQLRLEELADELYDKDVYILVDADESGEKLRKQLKREFNE ACHLHVDRAYKEVAAAPRHHIASVLLRANLNVHTIFLERKSRGV*" /label="yusF CDS" gene complement(2869471..2869911) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /label="yusF gene" CDS complement(2869911..2870147) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391158.1" /db_xref="EnsemblGenomes-Gn:BSU32790" /db_xref="EnsemblGenomes-Tr:CAB15268" /db_xref="InterPro:IPR020140" /db_xref="SubtiList:BG14019" /db_xref="UniProtKB/Swiss-Prot:O32173" /translation="MAFDKQKLDVTNDVTGRFQNGRLSLYHDNEMIGQMTSMNEYELK SGYSFENEKFYKTADVVSGDDAKYVDCDYENGWC*" /label="yusG CDS" gene complement(2869911..2870147) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /label="yusG gene" downshifts complement(2869923) /Source="Nicolas_upshifts" /id="D1697" /incds=0 /nref=35 /ntot=245 /MaxReadThrough="6.00162" /MaxDrop="3.9147" /score="-1.53913693" /energy="-11" /TU="U2570,U2571,U2572" /idTUdmin="U2574" /TUdmin=723 /isTUend="FALSE" /label="downshifts" upshifts complement(2870162) /Source="Nicolas_upshifts" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2870167..2870178) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2870193..2870199) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2870203..2870586) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 20882995, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine cleavage system protein H (lipoyl acceptor protein)" /protein_id="NP_391159.1" /db_xref="EnsemblGenomes-Gn:BSU32800" /db_xref="EnsemblGenomes-Tr:CAB15269" /db_xref="GOA:O32174" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR002930" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR017453" /db_xref="InterPro:IPR033753" /db_xref="SubtiList:BG14020" /db_xref="UniProtKB/Swiss-Prot:O32174" /translation="MSIPKDLRYSGEHEWVKVEGEKARIGITHFAQSELGDIVFVELP EVGAEIKADEPFGSVESVKTVSELYAPINGTVVEVNEDLDDSPEFVNESPYEKAWMIV VEPSDASEIEKLMTAEQYEEMTQED*" /label="gcvH CDS" gene complement(2870203..2870586) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /label="gcvH gene" promotor_-10 complement(2870613..2870632) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-10" upshifts complement(2870624) /Source="Nicolas_upshifts" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="upshifts" promotor_-35 complement(2870645..2870652) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-35" CDS complement(2870653..2871009) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /EC_number="1.20.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with thioredoxin domain and regulator domain" /protein_id="NP_391160.1" /db_xref="EnsemblGenomes-Gn:BSU32810" /db_xref="EnsemblGenomes-Tr:CAB15270" /db_xref="GOA:O32175" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14021" /db_xref="UniProtKB/Swiss-Prot:O32175" /translation="MSLTFYWYPKCGTCRKAKKWLEEHGKEINEIHIAEQPPSKEELK ALYEKSGLDLKKFFNTSGMKYRELNLKEKLYHMSEDEQLELLASDGMLIKRPLTTDGE KVTVGFKEDQFEENWA*" /label="yusI CDS" gene complement(2870653..2871009) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /label="yusI gene" promotor_-10 complement(2871032..2871051) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-10" upshifts complement(2871042) /Source="Nicolas_upshifts" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="upshifts" promotor_-35 complement(2871065..2871070) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-35" CDS complement(2871120..2872904) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase (FAD dependent)" /protein_id="NP_391161.1" /db_xref="EnsemblGenomes-Gn:BSU32820" /db_xref="EnsemblGenomes-Tr:CAB15271" /db_xref="GOA:O32176" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG14022" /db_xref="UniProtKB/Swiss-Prot:O32176" /translation="MAKKAADVQKGGGFLIEDVTYDQMYTPEDFTDEHKMIAKTTEDY IEQDVLPHIDDIENHQFEHSVRLLKKAGELGLLGADVPEEYGGLGLDKISSALITEKF SRAGSFSLSYGAHVGIGSLPIVFFGSEEQKKKYLPGLASGEKIAAYALTEPGSGSDAL GAKTTAVLNEAGTHYVLTGEKQWITNSAFADVFVVYAKVDGDKFSAFIVEKEFPGVST GPEEKKMGIKGSSTRTLILDQAEVPKENLLGEIGKGHVIAFNILNIGRYKLAVGTIGA SKRVIELSAAYANQRRQFKTPIAGFSLTQEKIGTMASRLYAMESSVYRTVGLFEDNMS QFTAEDLKDGRQIAKSIAEYAIECSLNKVFGSETLDYIVDEGVQIHGGYGFMQEYEVE RAYRDSRINRIFEGTNEINRLIVPSTFLKKALKGELPLFEKAQSLQEELMMLMPEEPG SGVLEQEKYIVKQAKKIALFAAGLAAQKYGKAIDREQEILVNVADIVSNVYAMESAVL RTEKAIAAQGAEKAAQKVLYTEIFVQEAFNEIEAHAKESLIAMEEGDSLRMMLSALRK LTRVTPKNVIQKKREAAAGIFEAEKYTV*" /label="fadE CDS" gene complement(2871120..2872904) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /label="fadE gene" downshifts complement(2871130) /Source="Nicolas_upshifts" /id="D1698" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="4.78872" /MaxDrop="6.88218" /score="31.8022607" /energy="-16.4" /TU="U2574" /idTUdmin="U2576" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2872919..2874094) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /EC_number="2.3.1.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acyltransferase" /protein_id="NP_391162.1" /db_xref="EnsemblGenomes-Gn:BSU32830" /db_xref="EnsemblGenomes-Tr:CAB15272" /db_xref="GOA:O32177" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG14023" /db_xref="UniProtKB/Swiss-Prot:O32177" /translation="MKEAVIVSGARTPVGKAKKGSLATVRPDDLGAICVKETLKRAGG YEGNIDDLIIGCATPEAEQGLNMARNIGALAGLPYTVPAITVNRYCSSGLQSIAYAAE KIMLGAYDTAIAGGAESMSQVPMMGHVTRPNLALAEKAPEYYMSMGHTAEQVAKKYGV SREDQDAFAVRSHQNAAKALAEGKFKDEIVPVEVTVTEIGEDHKPMEKQFVFSQDEGV RPQTTADILSTLRPAFSVDGTVTAGNSSQTSDGAAAVMLMDREKADALGLAPLVKFRS FAVGGVPPEVMGIGPVEAIPRALKLAGLQLQDIGLFELNEAFASQAIQVIRELGIDEE KVNVNGGAIALGHPLGCTGTKLTLSLIHEMKRRNEQFGVVTMCIGGGMGAAGVFELC* " /label="fadA CDS" gene complement(2872919..2874094) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /label="fadA gene" CDS complement(2874105..2876474) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /EC_number="1.1.1.35" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17189250, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase" /protein_id="NP_391163.2" /db_xref="EnsemblGenomes-Gn:BSU32840" /db_xref="EnsemblGenomes-Tr:CAB15273" /db_xref="GOA:O32178" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14024" /db_xref="UniProtKB/Swiss-Prot:O32178" /translation="MHKHIRKAAVLGSGVMGSGIAAHLANIGIPVLLLDIVPNDLTKE EEKKGLTKDSSEVRSRLSRQAMKKLLKQKPAPLTSAKNTSYITPGNLEDDAEKLKEAD WIIEVVVENLEVKKKIFALVDEHRKTGSIVSSNTSGISVQEMAEGRSDDFKAHFLGTH FFNPARYLKLLEIIPIKETDPDILKFMTAFGENVLGKGVVTAKDTPNFIANRIGTYGL LVTVQEMLKGGYQVGEVDSITGPLIGRPKSATFRTLDVVGLDTFAHVARNVYDKADGD EKEVFRIPSFMNDMLEKGWIGSKAGQGFYKKEGKTIYELDPVTLTYGERTKMKSPALE AAKQAKGTKAKMKALIYSDDRAGRLLWNITSQTLLYSAELLGEIADDIHAIDQAMKWG FGWELGPFEMWDAIGLKQSAEKLEQLGADMPGWIKEMLDKGNETFYIKENGTVFYYDR GEYRAVKENKKRIHLQALKETKGVIAKNSGASLIDLGDDVALLEFHSKSNAIGLDIIQ MIHKGLEETERNYKGLVIGNQGKNFCVGANLAMILMEVQDDNFLEVDFVIRRFQETMM KIKYSAKPVVAAPFGMTLGGGTEACLPAARIQAASEAYMGLVESGVGLIPGGGGNKEL YINHLRRGHDPMNAAMKTFETIAMAKVSASAQEAREMNILKETDQISVNQDHLLYDAK QLAASLYDTGWRPPVKEKVKVPGETGYAALLLGAEQMKLSGYISEHDFKIAKKLAYVI AGGKVPFGTEVDEEYLLEIEREAFLSLSGEAKSQARMQHMLVKGKPLRN*" /label="fadN CDS" gene complement(2874105..2876474) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /label="fadN gene" promotor_-35 2875893..2875898 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2875913..2875931 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2875916 /Source="Nicolas_upshifts" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2876542..2876561) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-10" upshifts complement(2876545) /Source="Nicolas_upshifts" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="upshifts" S_feature complement(2876553..2876819) /Source="Nicolas_S_feature" /locus_tag="new_3372473_3372739_c" /HighExp="S8, S6, S7, BT, B36, G/S, B60, S5, Pyr, S3" /AntisenseName="yuzL" /AntisenseCor="0.77564732124057401" /AntisenseRegPval="-54.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1264" promotor_-35 complement(2876575..2876582) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-35" promotor_-35 2876600..2876606 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2876621..2876632 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2876643 /Source="Nicolas_upshifts" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="upshifts" CDS 2876649..2876795 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17189250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097783.1" /db_xref="EnsemblGenomes-Gn:BSU32849" /db_xref="EnsemblGenomes-Tr:CAX52689" /db_xref="InterPro:IPR025625" /db_xref="UniProtKB/Swiss-Prot:C0H3R0" /translation="MVREKKNPSSAAVSAASVKGDAGPTQHYGGGKRTSQNQQYKKHN MGQS*" /label="yuzL CDS" gene 2876649..2876795 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /label="yuzL gene" S_feature 2876796..2877822 /Source="Nicolas_S_feature" /locus_tag="new_3372716_3373742" /HighExp="S8, S5, S7, S4, S6, nit, ferm, T5.0H, S3, LoTm" /AntisenseName="fadM" /AntisenseCor="0.80952501049450498" /AntisenseRegPval="-63" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1265" CDS complement(2876820..2877728) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /EC_number="1.5.5.2" /function="3.2: Degradation" /experiment="publication(s) with functional evidences, PMID:17189250, 17536821, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 17536821, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline dehydrogenase 1" /protein_id="NP_391164.1" /db_xref="EnsemblGenomes-Gn:BSU32850" /db_xref="EnsemblGenomes-Tr:CAB15274" /db_xref="GOA:O32179" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG14025" /db_xref="UniProtKB/Swiss-Prot:O32179" /translation="MLRHVFLFLSQNKTLTKFAKAYGTRLGARRFVAGDTIESAVKTV KRLNRSGLCATIDYLGEYAASEKEANQVAEECKKAIQAIAEHQLNSELSLKLTSIGLD LSEELALTHLRAILSVAKQYDVAVTIDMEDYSHYEQTLSIYRQCKQEFEKLGTVIQAY LYRAAEDIRKMRDLKPNLRLVKGAYKESAAVAFPDKRGTDLHFQSLIKLQLLSGNYTA VATHDDDIIAFTKQLVAEHQIPASQFEFQMLYGIRPERQKELAKEGYRMRVYVPYGTD WFSYFMRRIAERPANAAFVLKGILKK*" /label="putM CDS" gene complement(2876820..2877728) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /label="putM gene" S_feature complement(2877729..2878251) /Source="Nicolas_S_feature" /locus_tag="new_3373649_3374171_c" /HighExp="S8, S6, S7, BT, B36, B60, G/S, Pyr, S5, SMMPr" /AntisenseName="yuzM" /AntisenseCor="0.77827902986544495" /AntisenseRegPval="-55.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1266" CDS 2877823..2878068 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097784.1" /db_xref="EnsemblGenomes-Gn:BSU32859" /db_xref="EnsemblGenomes-Tr:CAX52690" /db_xref="InterPro:IPR012347" /db_xref="UniProtKB/Swiss-Prot:C0H3R1" /translation="MDNQQQSQMPPSVISTKDHLYLNDMLNWNLLAMKKAHFMAQQCQ DQTLKQELDRVGHMHHDHYQRILKHLQPGQQQSGYIQ*" /label="yuzM CDS" gene 2877823..2878068 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /label="yuzM gene" CDS 2878081..2878413 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat-like protein" /protein_id="NP_391165.1" /db_xref="EnsemblGenomes-Gn:BSU32860" /db_xref="EnsemblGenomes-Tr:CAB15275" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG14026" /db_xref="UniProtKB/Swiss-Prot:O32180" /translation="MNQQNQKISNPQTPVPTTSEMNDRDFVNELLTTEKYMTTAYCTA LHEFSHESLYQDIQSIFDESQKAQRKLYDLMFQYGWYSVEAEDSQKLQQSYQKFQQTI QQQSPYQQ*" /label="yusN CDS" gene 2878081..2878413 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /label="yusN gene" promotor_-10 complement(2878234..2878253) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2878251) /Source="Nicolas_upshifts" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2878267..2878276) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2878402 /Source="Nicolas_upshifts" /id="D1699" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="2.684" /MaxDrop="5.38418" /score="9.88876972" /energy="-10.2" /TU="NA" /idTUdmin="U2575" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2878474..2878481 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2878495..2878514 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2878506 /Source="Nicolas_upshifts" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="upshifts" CDS 2878572..2879039 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12923086, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923086, 19286808; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, low level antibiotic resistance)" /protein_id="NP_391166.1" /db_xref="EnsemblGenomes-Gn:BSU32870" /db_xref="EnsemblGenomes-Tr:CAB15276" /db_xref="GOA:O32181" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1S3J" /db_xref="SubtiList:BG14027" /db_xref="UniProtKB/Swiss-Prot:O32181" /translation="MKSADQLMSDIQLSLQALFQKIQPEMLESMEKQGVTPAQLFVLA SLKKHGSLKVSEIAERMEVKPSAVTLMADRLEQKNLIARTHNTKDRRVIDLSLTDEGD IKFEEVLAGRKAIMARYLSFLTEEEMLQAAHITAKLAQAAETDEKQNMKRGNG*" /label="mdtR CDS" gene 2878572..2879039 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /label="mdtR gene" CDS 2879036..2880661 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19286808; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_391167.1" /db_xref="EnsemblGenomes-Gn:BSU32880" /db_xref="EnsemblGenomes-Tr:CAB15277" /db_xref="GOA:O32182" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14028" /db_xref="UniProtKB/Swiss-Prot:O32182" /translation="MKMSKEGKQSKRTLLITGLIIAMFFSALDGTIVGTAMPKIVGDL GGLSMMTWLTTAYLLTSTTIVPIAGKLADLLGRRIVYVSGLIIFMAASALCGMANNMT ELIIFRGLQGIGGGIMMPMAMIVIGDLFTGKQRAKFQGVFGAIYGLASVIGPQIGGWI VDSLNWKWVFYINLPVGIIAVIFIARGLQGRQQTGPINFDIAGIFTMIVGVVSLLLAL SFGGKDYAWDSWQILGLFALALIGIVSFIIVESKAKEPILPMYLFKNRTFTFLNLIGF FMSIGMFGAITFVPFFMQGIVGVSASESGTIMTPMMISMIITSIIGGQLVYKIGIKPQ IITGMLVMAGGFLLLTTLDLDTSKLVATSFMAIIGLGMGLVMPILTLALQESFSKEEL GVVTSSSQFFRSIGGTFGITMLGAVMNARSGNLLTDKLVPYLDSLPAQASSFAAQLKG MIDTNPQGLLQSLFSPDAVKQIPAAFSSHIVPILKTSLMDSLHSVFYTGLIFIAVGAV FTLFLKPIKLSNKKAEDQQEKEKAAKAVESPSH*" /label="mdtP CDS" gene 2879036..2880661 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /label="mdtP gene" downshifts 2880646 /Source="Nicolas_upshifts" /id="D1700" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="0.3188" /MaxDrop="5.64223" /score="42.0555168" /energy="-17.7" /TU="NA" /idTUdmin="U2577" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2880697..2881080) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /EC_number="5.3.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25219626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydratase of unidentified specificity (tautomerase superfamily)" /protein_id="NP_391168.1" /db_xref="EnsemblGenomes-Gn:BSU32890" /db_xref="EnsemblGenomes-Tr:CAB15278" /db_xref="GOA:O32183" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG14029" /db_xref="UniProtKB/Swiss-Prot:O32183" /translation="MPFVQIHLRSGRSEVWLQKLSRTIHQSMIEEINVPEDDYFQVIR QYEKSEFFYDPFYLQVERTDELIYIHFTLKQSRTTEQKKALYRSIASRIHSELGVRKE DVFIMLAGNQDEDWSFGNGRAQMIE*" /label="yusQ CDS" gene complement(2880697..2881080) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /label="yusQ gene" CDS complement(2881099..2881488) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15294834; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_391169.1" /db_xref="EnsemblGenomes-Gn:BSU32900" /db_xref="EnsemblGenomes-Tr:CAB15279" /db_xref="GOA:O32184" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14030" /db_xref="UniProtKB/Swiss-Prot:O32184" /translation="MKGMFFCARAVVPFMKKSKDGAIVNVGSIAGITGAGSSMPYAVS KSAVHGLTKSLAHALAPEIRVSGVAPGAVATRWWAGREEKMKSMIGSLLLQCIAEPDD VAKLICSLIEQESLTGQIITIDSGQTL*" /label="yusR CDS" gene complement(2881099..2881488) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /label="yusR gene" CDS complement(2881510..2881839) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved enzyme of unknown function" /protein_id="NP_391170.1" /db_xref="EnsemblGenomes-Gn:BSU32910" /db_xref="EnsemblGenomes-Tr:CAB15280" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14031" /db_xref="UniProtKB/Swiss-Prot:O32185" /translation="MNVLNKIALVTGGGTGIGKAASMELAKRGAIVAVNYSRSQSEAE ETVEMIQKAGGQAFAIQADVSKNSDVQDMIQAIVNTHGTVDILVNNASITRHIPMDDL EAATEDV*" /label="yusS CDS" gene complement(2881510..2881839) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /label="yusS gene" promotor_-10 complement(2881874..2881893) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2881881..2881888 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2881888) /Source="Nicolas_upshifts" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2881903..2881922 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2881907..2881914) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2881913 /Source="Nicolas_upshifts" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="upshifts" CDS 2881973..2882860 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591, 17526699, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591, 17526699, 27965289; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown specificity(LysR family)" /protein_id="NP_391171.1" /db_xref="EnsemblGenomes-Gn:BSU32920" /db_xref="EnsemblGenomes-Tr:CAB15281" /db_xref="GOA:O32186" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14032" /db_xref="UniProtKB/Swiss-Prot:O32186" /translation="MESGDLRVFQMVAREGTITKAALQLGYVQSNVTARIQQLEAELG TTLFLRHNRGMTLSASGKLLLDYANKIIGLLDEASKALSSSAEPSGPLMIGCTQTTAA VRLPKLLASYYEEHPNVQLSLTTGHTQFLLDKVLRYELDGAFIGCECHHPELESYPAF EEEPVVVSAASVPDVEEAITKPILVYSTGCSYRETLEKWLRSVGVTQPVIMEFGTLEA IIGGVTAGLGISLLPRTVVQKHEAEGSIRLYPLPEALSQMKTEFIVRKDSFISSALRT FMDSFTPVKTAESQKSSLL*" /label="yusT CDS" gene 2881973..2882860 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /label="yusT gene" CDS complement(2882880..2883167) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22078549" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391172.1" /db_xref="EnsemblGenomes-Gn:BSU32930" /db_xref="EnsemblGenomes-Tr:CAB15282" /db_xref="InterPro:IPR020393" /db_xref="SubtiList:BG14033" /db_xref="UniProtKB/Swiss-Prot:O32187" /translation="MRKLLAVFSKGRWKMEQKLQEQLDGLLEKYTELLLGETNDELKE EVKQWILYTHIAKSMPPLAKHWNATYPDAKQGIKEIIQHIKELNEAHRNKQ*" /label="yusU CDS" gene complement(2882880..2883167) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /label="yusU gene" downshifts complement(2882892) /Source="Nicolas_upshifts" /id="D1701" /incds=0 /nref=113 /ntot=280 /MaxReadThrough="1.05563" /MaxDrop="5.97768" /score="17.1690128" /energy="-13.2" /TU="NA" /idTUdmin="U2580" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(2883192..2884019) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 24847778, 25288929; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III)-siderophore transporter (ATP binding component)" /protein_id="NP_391173.1" /db_xref="EnsemblGenomes-Gn:BSU32940" /db_xref="EnsemblGenomes-Tr:CAB15283" /db_xref="GOA:O32188" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14034" /db_xref="UniProtKB/Swiss-Prot:O32188" /translation="MGMSAISTETLSLGYGDAVIIDELNLTIPKGEITVFIGSNGCGK STLLRSLARLMKPRGGSVLLEGRAIAKLPTKEVAKELAILPQGPSAPEGLTVHQLVKQ GRYPYQNWLKQWSKEDEEAVERALKATKLEDMADRAVDSLSGGQRQRAWIAMTLAQET DIILLDEPTTYLDMTHQIEILDLLFELNEKEDRTIVMVLHDLNLACRYAHHLVAIKDK RIYAEGRPEEVITCDLVQNVFSMNCQVTQDPLFGTPLCIPHGRGRCIVQEAAFTSHG* " /label="feuV CDS" gene complement(2883192..2884019) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /label="feuV gene" downshifts complement(2883208) /Source="Nicolas_upshifts" /id="D1702" /incds=0 /nref=2 /ntot=77 /MaxReadThrough="5.36684" /MaxDrop="3.19022" /score="11.3999731" /energy="-19.8" /TU="U2580" /idTUdmin="U2581" /TUdmin=220 /isTUend="FALSE" /label="downshifts" S_feature complement(2884020..2884157) /Source="Nicolas_S_feature" /locus_tag="new_3379940_3380077_c" /HighExp="T-5.40H, Paraq, H2O2, GM-0.2, HiOs, GM 5, dia15, GM 25, T-3.40H, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1267" promotor_-10 complement(2884142..2884161) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2884157) /Source="Nicolas_upshifts" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2884177..2884180) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2884237..2884674) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26497467; Product type m : membrane component" /codon_start=1 /transl_table=11 /product="spore lipoprotein" /protein_id="NP_391174.1" /db_xref="EnsemblGenomes-Gn:BSU32950" /db_xref="EnsemblGenomes-Tr:CAB15284" /db_xref="InterPro:IPR025623" /db_xref="SubtiList:BG14035" /db_xref="UniProtKB/Swiss-Prot:O32189" /translation="MHLIRAAGAVCLAVVLIAGCRFNEDQHQAEGENTAVTQLKSVPY SNFSLRVSYGDGEHNRYEGIYTKNGTQEKAEIQDKLSGVNQEGEEALDEMKMILSELS VTDQMAETEVIHSVLAAFNLDSHYDHIDLKLKLKDGSIREIKK*" /label="cotNW CDS" gene complement(2884237..2884674) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /label="cotNW gene" promotor_-10 complement(2884698..2884716) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-10" upshifts complement(2884704) /Source="Nicolas_upshifts" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="upshifts" promotor_-35 complement(2884732..2884737) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-35" CDS complement(2884784..2886292) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; C-terminal part of YusY" /db_xref="SubtiList:BG14037" /translation="GLMNRLSADFQSSLVTLDHKLVDINQDVWNELLTKPGLRDVSYI LNERRQRVAEKLSPGKEKLIGNLAVDGYHAWSDLYNMVVGKMTIPYEENGENKQLSVG QAENMMDHQDRTVRKTVYERFRQAWESKQDIFSSTLNHLAGFRLETYKARGWENVLKE PLQINRMKKETLDTMWQVITENKKPFVQFLNRKASMLGLEKLSWYDVEAPIGSDGKVY SYDEAANIITSQFSTFGKKLSSFTEKAFRDGWIEAEDRSGKRVGGFCTSFPDSGESRI FMTFSGSASNVSTLAHELGHAFHQEAMLNVRPLNRSYAMNVAETASTFAEMIVADATV QQAETREEKLVLLEDKVQRSVAFFMNIHARFLFETRFYEERKRGVVPASRLNELMEEA QREAYCNALEEYHPLFWASKLHFHITRVPFYNFPYTFGYLFSLGIYALALEEKDTFEE KYMALLRDTASMTVEDLAMKHLGADITKRDFWENAIKLAVRDAETFLQMTES*" /label="yusYc CDS" gene complement(2884784..2886292) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /pseudo /label="yusYc gene" downshifts complement(2884805) /Source="Nicolas_upshifts" /id="D1703" /incds=0 /nref=125 /ntot=240 /MaxReadThrough="2.57385" /MaxDrop="6.5698" /score="6.83314975" /energy="-12" /TU="NA" /idTUdmin="U2582" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" CDS complement(2886283..2886579) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; N-terminal part of YusY" /translation="MALQGVGQRWDLDSFFKGGSQSEEFKGYIEKLSQSLRAFQDRTD AFQVPESPEEAEGLTALLDLFEQTSVKLQQAGAFVACLQAQNINDQKAIEHQAS*" /label="yusYn CDS" gene complement(2886283..2886579) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /pseudo /label="yusYn gene" promotor_-10 complement(2886602..2886621) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2886618) /Source="Nicolas_upshifts" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2886636..2886639) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2886656..2886661 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2886673..2886692 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2886673 /Source="Nicolas_upshifts" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="upshifts" CDS 2886713..2887555 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative short-chain acyl dehydrogenase" /protein_id="NP_391177.1" /db_xref="EnsemblGenomes-Gn:BSU32980" /db_xref="EnsemblGenomes-Tr:CAB15287" /db_xref="GOA:P37959" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10863" /db_xref="UniProtKB/Swiss-Prot:P37959" /translation="MNKKIAIVTGASSGFGLLAAVKLARSFFVIATSRQPEKAEQLRE LAAAHNVSDSIHITALDVTDEQSIVSFGKAVSAYAPIDLLVNNAGTAYGGFIEDVPME HFRQQFETNVFGVIHVTKTVLPYIRKHGGAKIINVSSISGLTGFPALSPYVSSKHALE GFSESLRIELLPFGIETALIEPGSYKTSIWSTSLSNFMSVPADDSAYHQYYKKILSYV QKNGEESGDPQEVADLIYQLATKQHIKNLRYPIGKGIKLTLLFRSLFPWSAWESILKK KLFS*" /label="yusZ CDS" gene 2886713..2887555 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /label="yusZ gene" promotor_-35 2887085..2887091 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-35" promotor_-10 2887106..2887117 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-10" upshifts 2887114 /Source="Nicolas_upshifts" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="upshifts" promotor_-35 2887582..2887589 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2887598 /Source="Nicolas_upshifts" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2887601..2887620 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2887645..2888106 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 8709848, 21057011, 22194458, 24123749, 28434086" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 8709848, 21057011, 22194458, 24123749, 28434086; Product type f : factor" /codon_start=1 /transl_table=11 /product="metalloregulation DNA-binding stress protein" /protein_id="NP_391178.1" /db_xref="EnsemblGenomes-Gn:BSU32990" /db_xref="EnsemblGenomes-Tr:CAB15288" /db_xref="GOA:P37960" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="PDB:2CHP" /db_xref="SubtiList:BG10864" /db_xref="UniProtKB/Swiss-Prot:P37960" /translation="MKTENAKTNQTLVENSLNTQLSNWFLLYSKLHRFHWYVKGPHFF TLHEKFEELYDHAAETVDTIAERLLAIGGQPVATVKEYTEHASITDGGNETSASEMVQ ALVNDYKQISSESKFVIGLAEENQDNATADLFVGLIEEVEKQVWMLSSYLG*" /label="mrgA CDS" gene 2887645..2888106 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /label="mrgA gene" downshifts 2888082 /Source="Nicolas_upshifts" /id="D1704" /incds=0 /nref=234 /ntot=274 /MaxReadThrough="1.7919" /MaxDrop="8.26581" /score="36.5549876" /energy="-13.3" /TU="NA" /idTUdmin="U2583" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2888150..2889526) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423; Product type f: factor" /codon_start=1 /transl_table=11 /product="protease-associated chaperone for the extracytoplasmic folding and quality control of exported proteins" /protein_id="NP_391180.2" /db_xref="EnsemblGenomes-Gn:BSU33000" /db_xref="EnsemblGenomes-Tr:CAB15290" /db_xref="GOA:Q9R9I1" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14155" /db_xref="UniProtKB/Swiss-Prot:Q9R9I1" /translation="MDYRRDGQNDQHQTEPSHTEQQNTENQKLIGHSEQELLDAPVSY EAGRQETASALEMEKQETAVKKEKKRRAAWLSPILGGIIGGGLMLGIAPYLPSDQNQA TETASANKQVQSDNFTTAPITNASNIADMVEDLEPTIVGISNIQTSQNNTFGTGGGSS SESESGTGSGVIFKKDSDKAYIITNNHVVEGANKLTVTLYNGETETAKLVGSDTITDL AVLEISGKNVKKVASFGDSSQLRTGEKVIAIGNPLGQQFSGTVTQGIISGLNRTIDVD TTQGTVEMNVLQTDAAINPGNSGGPLINASGQVIGINSLKVSESGVESLGFAIPSNDV EPIVDQLLQNGKVDRPFLGVQMIDMSQVPETYQENTLGLFGDQLGKGVYVKEVQANSP AEKAGIKSEDVIVKLNGKDVESSADIRQILYKDLKVGDKTTIQVLRKGKTKTLNATLT KQTESSSS*" /label="htrB CDS" gene complement(2888150..2889526) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /label="htrB gene" downshifts complement(2888158) /Source="Nicolas_upshifts" /id="D1705" /incds=0 /nref=206 /ntot=257 /MaxReadThrough="1.84997" /MaxDrop="6.39104" /score="17.1953741" /energy="-11.2" /TU="U2586" /idTUdmin="U2586" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2889527..2889698) /Source="Nicolas_S_feature" /locus_tag="new_3385447_3385618_c" /HighExp="SMMPr, T-0.40H, T-1.10H, M9-tran, T-1.40H, T1.0H, T0.30H, T1.30H, Etha, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67259999999999998" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1268" promotor_-10 complement(2889679..2889698) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2889698) /Source="Nicolas_upshifts" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2889709..2889716) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2889759..2889778) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-10" misc_feature 2889769..2889788 /Source="Nicolas_upshift_promotors" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2889771 /Source="Nicolas_upshifts" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2889777) /Source="Nicolas_upshifts" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="upshifts" S_feature complement(2889779..2890842) /Source="Nicolas_S_feature" /locus_tag="new_3385699_3386762_c" /HighExp="T1.0H, T0.30H, T1.30H, C30, T2.0H, G135, G180, T2.30H, ferm, G150" /AntisenseName="cssR" /AntisenseCor="0.115381389160342" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1269" promotor_-35 complement(2889793..2889800) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-35" CDS 2889804..2890481 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type r: regulator" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component response regulator" /protein_id="NP_391181.1" /db_xref="EnsemblGenomes-Gn:BSU33010" /db_xref="EnsemblGenomes-Tr:CAB15291" /db_xref="GOA:O32192" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14131" /db_xref="UniProtKB/Swiss-Prot:O32192" /translation="MSYTIYLVEDEDNLNELLTKYLENEGWNITSFTKGEDARKKMTP SPHLWILDIMLPDTDGYTLIKEIKAKDPDVPVIFISARDADIDRVLGLELGSNDYISK PFLPRELIIRVQKLLQLVYKEAPPVQKNEIAVSSYRVAEDAREVYDENGNIINLTSKE FDLLLLFIHHKGHPYSREDILLKVWGHDYFGTDRVVDDLVRRLRRKMPELKVETIYGF GYRMMSS*" /label="cssR CDS" gene 2889804..2890481 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /label="cssR gene" CDS 2890478..2891833 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component sensor histidine kinase" /protein_id="NP_391182.2" /db_xref="EnsemblGenomes-Gn:BSU33020" /db_xref="EnsemblGenomes-Tr:CAB15292" /db_xref="GOA:O32193" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14132" /db_xref="UniProtKB/Swiss-Prot:O32193" /translation="MKNKPLAFQIWVVISGILLAISILLLVLFSNTLRDFFTNETYTT IENEQHVLTEYRLPGSIERRYYSEEATAPTTVRSVQHVLLPENEEASSDKDLSILSSS FIHKVYKLADKQEAKKKRYSADVNGEKVFFVIKKGLSVNGQSAMMLSYALDSYRDDLA YTLFKQLLFIIAVVILLSWIPAIWLAKYLSRPLVSFEKHVKRISEQDWDDPVKVDRKD EIGKLGHTIEEMRQKLVQKDETERTLLQNISHDLKTPVMVIRGYTQSIKDGIFPKGDL ENTVDVIECEALKLEKKIKDLLYLTKLDYLAKQKVQHDMFSIVEVTEEVIERLKWARK ELSWEIDVEEDILMPGDPEQWNKLLENILENQIRYAETKIEISMKQDDRNIVITIKND GPHIEDEMLSSLYEPFNKGKKGEFGIGLSIVKRILTLHKASISIENDKTGVTYRIAVP K*" /label="cssS CDS" gene 2890478..2891833 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /label="cssS gene" S_feature complement(2890932..2891860) /Source="Nicolas_S_feature" /locus_tag="new_3386852_3387780_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, ferm, C30, LPhT, T-1.10H, Lbstat" /AntisenseName="cssS" /AntisenseCor="0.27217686232372901" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigD, SigH, SigA" /TUshortPSig="1, 0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1270" downshifts 2891801 /Source="Nicolas_upshifts" /id="D1706" /incds=0 /nref=61 /ntot=203 /MaxReadThrough="0.95076" /MaxDrop="4.47937" /score="13.0972324" /energy="-9.7" /TU="NA" /idTUdmin="U2587" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2891861..2892025) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /experiment="publication(s) with functional evidences, PMID:21378193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21378193; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpxA degradation" /protein_id="YP_003097785.1" /db_xref="EnsemblGenomes-Gn:BSU33029" /db_xref="EnsemblGenomes-Tr:CAX52691" /db_xref="GOA:O32302" /db_xref="UniProtKB/Swiss-Prot:O32302" /translation="MRELDEMISRLRNRGIKVEKVKYPKQTLSEKKWVHQCKQPLKTN YRDFNGYSFT*" /label="spxO CDS" gene complement(2891861..2892025) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /label="spxO gene" promotor_-35 2892049..2892056 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2892070..2892089 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2892074..2892093) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2892080..2892192 /Source="Nicolas_S_feature" /locus_tag="new_3388000_3388112" /HighExp="dia5, Diami, T0.30H, T-0.40H, T0.0H, dia15, Salt, ferm, G135, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1271" upshifts 2892080 /Source="Nicolas_upshifts" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2892087) /Source="Nicolas_upshifts" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2892089..2892367) /Source="Nicolas_S_feature" /locus_tag="new_3388009_3388287_c" /HighExp="Etha, Gly, S2, Glucon, Pyr, G/S, S1, Lbstat, Cold, HiTm" /AntisenseName="yuxN" /AntisenseCor="-0.128326996122899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigH, SigA" /TUshortPSig="0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1272" promotor_-35 complement(2892107..2892114) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2892193..2893068 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391183.1" /db_xref="EnsemblGenomes-Gn:BSU33030" /db_xref="EnsemblGenomes-Tr:CAB15293" /db_xref="GOA:P40950" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG11072" /db_xref="UniProtKB/Swiss-Prot:P40950" /translation="MKEKEKLIIETALKLFAQKGYNSTSVQEIAKECKISKGAFYIYF PSKEALLLSMLNYYYDKTFTRILNIKTKGDSPRTAYRKQLTVLYENILEHKDFISMQL KEGSLPYTEEVEQCAKKIRQSSLQFHIDSLLNIYGKKAEPYTAELCFLIEGISQIYLE CMILLGYTVKPSQLADIIMNRIDDMVKGMSERNDKPFITLEEASSLFGPLTHGRPDPL TESIVKSLRDKINSLNTNSSLELSESLDILEAEMKKKTPKLAIIKGMIHNLTESEALA KDAEQLKYLLKQQHI*" /label="yuxN CDS" gene 2892193..2893068 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /label="yuxN gene" promotor_-10 complement(2892357..2892376) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2892367) /Source="Nicolas_upshifts" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2892369..2892910) /Source="Nicolas_S_feature" /locus_tag="new_3388289_3388830_c" /HighExp="LBGstat, Cold, S2, Glucon, S1, Pyr, G/S, C30, GM 10, GM-0.1" /AntisenseName="yuxN" /AntisenseCor="-0.341746670828522" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigH, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1273" promotor_-35 complement(2892390..2892397) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2892902..2892920) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2892910) /Source="Nicolas_upshifts" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2892912..2893041) /Source="Nicolas_S_feature" /locus_tag="new_3388832_3388961_c" /HighExp="S2, S1, G/S, Glucon, Pyr, T3.30H, M9-stat, BT, Cold, T4.0H" /AntisenseName="yuxN" /AntisenseCor="-0.30886083736579201" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1274" promotor_-35 complement(2892933..2892940) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2893043 /Source="Nicolas_upshifts" /id="D1707" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="3.14099" /MaxDrop="3.7614" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2589" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" downshifts complement(2893086) /Source="Nicolas_upshifts" /id="D1708" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="5.30537" /MaxDrop="3.29426" /score="-2.73895091" /energy="-13.6" /TU="U2593,U2594" /idTUdmin="U2591" /TUdmin="-1584" /isTUend="FALSE" /label="downshifts" CDS complement(2893104..2894492) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /EC_number="4.2.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:2509422, 3130545, 3923430, 9647666, 22914898, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509422, 3130545, 3923430, 9647666, 22914898, 28032445; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fumarate hydratase" /protein_id="NP_391184.1" /db_xref="EnsemblGenomes-Gn:BSU33040" /db_xref="EnsemblGenomes-Tr:CAB15294" /db_xref="GOA:P07343" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR005677" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10384" /db_xref="UniProtKB/Swiss-Prot:P07343" /translation="MEYRIERDTMGEVKVPADKFWGAQTQRSKENFKIGSEKMPMRVV KAFAILKRSTALANKRLGNLDAEKAEAIAAVCDDVLKGKYDDNFPLVVWQTGSGTQSN MNMNEVVANRATALLKEKNSDQTIHPNDDVNRSQSSNDTFPTAMHVAAVLAVYEQLVP ALDQLRNTLDEKAKAYNDIVKIGRTHLQDATPLTLGQEISGWVHMLDRSKEMILEATD KMRALAIGGTAVGTGINAHPEFGELVSEEITKLTGQTFSSSPNKFHALTSHDEITYAH GALKALAADLMKIANDVRWLASGPRCGIGEIVIPENEPGSSIMPGKVNPTQSEALTMI AAQIMGNDATIGFAASQGNFELNVFKPVIIYNFLQSVQLLSDGMNSFHDKCAVGIEPN KETIQENLSNSLMLVTALNPHIGYENAAKIAKLAHKEGLTLKEAALKLELLTEEQFNE MVKPEDMVKPKA*" /label="fumC CDS" gene complement(2893104..2894492) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /label="fumC gene" upshifts complement(2894516) /Source="Nicolas_upshifts" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2894521..2894539) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2894550..2894558) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2894559..2894744) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097786.1" /db_xref="EnsemblGenomes-Gn:BSU33049" /db_xref="EnsemblGenomes-Tr:CAX52692" /db_xref="InterPro:IPR025088" /db_xref="UniProtKB/Swiss-Prot:C0H3R3" /translation="MAQVRLAGKQEEIEQLIRSFEQHYDVSYTSKEYGRTNPKYKYSK DSRVYLELKLKSAKIEK*" /label="yvzF CDS" gene complement(2894559..2894744) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /label="yvzF gene" downshifts 2894748 /Source="Nicolas_upshifts" /id="D1709" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="1.13377" /MaxDrop="4.4478" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2595" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2894788..2894807) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2894797..2894803 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2894802) /Source="Nicolas_upshifts" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2894817..2894828 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2894820 /Source="Nicolas_upshifts" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2894823..2894826) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2894862..2896310 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the GerA germination receptor" /protein_id="NP_391185.2" /db_xref="EnsemblGenomes-Gn:BSU33050" /db_xref="EnsemblGenomes-Tr:CAB15295" /db_xref="GOA:P07868" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10385" /db_xref="UniProtKB/Swiss-Prot:P07868" /translation="MEQTEFKEYIHDNLALVLPKLKENDDLVKNKKMLANGLVFYYLY FSEMTDENKVSEAIKTLIKDEETLTLDQVKKRLDQLDARPVETAKKTIESILNGNCAV FINGLDKAYILTTGKKKTRSLTEPTTEKVVRGPKVAFVEDIDTNLALIRQRTSHPKLI TKKIMIGENKLKPAAIMYIEGKAKKSVIKEVKARLKNIQLEDIQDSGTLEELIEDNKY SPFPQIQNTERPDKVSSALFNGRVAILVDSSPFVLLVPVSLGILMQSPDDYYERWISA SLIRSLRFASIFITLFLSSIYITLVSFHQGLLPTALAVTISANRENVPFPPIFEALLM EVTIELLREAGLRLPNPLGQTIGLVGGVVIGQAAVEANLVSSILVIVVSVIALASFTV PQYGMGLSFRVLRFISMFSAAILGLYGIILFMLVVYTHLTRQTSFGSPYFSPNGFFSL KNTDDSIIRLPIKNKPKEVNNPNEPKTDSTET*" /label="gerAA CDS" gene 2894862..2896310 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /label="gerAA gene" S_feature complement(2895858..2898501) /Source="Nicolas_S_feature" /locus_tag="new_3391778_3394421_c" /HighExp="Cold, H2O2, G135, G180, Paraq, G150, Oxctl, T-5.40H, LBGstat, T-4.40H" /AntisenseName="gerAC" /AntisenseCor="-9.7163861003102397E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1275" CDS 2896279..2897376 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16740944, 16850406, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16740944, 16850406, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA; putative transporter" /protein_id="NP_391186.1" /db_xref="EnsemblGenomes-Gn:BSU33060" /db_xref="EnsemblGenomes-Tr:CAB15296" /db_xref="GOA:P07869" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG10386" /db_xref="UniProtKB/Swiss-Prot:P07869" /translation="MSQKQTPLKLNTFQGISIVANTMLGAGLLTLPRALTTKANTPDG WITLILEGFIFIFFIYLNTLIQKKHQYPSLFEYLKEGLGKWIGSIIGLLICGYFLGVA SFETRAMAEMVKFFLLERTPIQVIILTFICCGIYLMVGGLSDVSRLFPFYLTVTIIIL LIVFGISFKIFDINNLRPVLGEGLGPIANSLTVVSISFLGMEVMLFLPEHMKKKKYTF RYASLGFLIPIILYILTYIIVVGALTAPEVKTLIWPTISLFQSFELKGIFIERFESFL LVVWIIQFFTTFVIYGYFAANGLKKTFGLSTKTSMVIIGITVFYFSLWPDDANQVMMY SDYLGYIFVSLFLLPFILFFIVALKRRITTK*" /label="gerAB CDS" gene 2896279..2897376 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /label="gerAB gene" CDS 2897373..2898494 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA" /protein_id="NP_391187.1" /db_xref="EnsemblGenomes-Gn:BSU33070" /db_xref="EnsemblGenomes-Tr:CAB15297" /db_xref="GOA:P07870" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG10387" /db_xref="UniProtKB/Swiss-Prot:P07870" /translation="MKIRILCMFICTLLLSGCWDSENIEELSLVIGIGLDKPDDENLE LTQQILVPKIISAKEGSSSDPTQLSITKGKTVHQMMRTSALKHKPTFSQHLRLILLSK SVIADQIGMDAIINQFVRDNGTRRSSYVFITNGRTKDIFNMNDEGEPASNVIYDLTEN NKVTIRTMEPVTLGEISEHLTSDDSFLIPHVGKENGKLAINGASIIKNKLWHRDLTPI EVQNISLFSGTVEGGVIDLKRDGHLFSYEVYSSNRKIKTAYKDGKFKFTVTRNIEGRL SEDWNPNEDSFKDSYIKSIEKTVEKRVHETVTSFITEKLQKEIKADVTGLGNEVRIHY PQKWKKISRKWDDDYFSNAEIDYRVNVIVRDFGTKGANK*" /label="gerAC CDS" gene 2897373..2898494 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /label="gerAC gene" CDS complement(2898502..2899137) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvqE] responding to cell wall stress" /protein_id="NP_391188.1" /db_xref="EnsemblGenomes-Gn:BSU33080" /db_xref="EnsemblGenomes-Tr:CAB15298" /db_xref="GOA:O32197" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14133" /db_xref="UniProtKB/Swiss-Prot:O32197" /translation="MIRVLLIDDHEMVRMGLAAFLEAQPDIEVIGEASDGSEGVRLAV ELSPDVILMDLVMEGMDGIEATKQICRELSDPKIIVLTSFIDDDKVYPVIEAGALSYL LKTSKAAEIADAIRAASKGEPKLESKVAGKVLSRLRHSGENALPHESLTKRELEILCL IAEGKTNKEIGEELFITIKTVKTHITNILSKLDVSDRTQAAVYAHRNHLVN*" /label="liaR CDS" gene complement(2898502..2899137) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /label="liaR gene" CDS complement(2899115..2900197) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /function="16.12: Sense" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LiaR(YvqC)] sensing cell wall stress" /protein_id="NP_391189.1" /db_xref="EnsemblGenomes-Gn:BSU33090" /db_xref="EnsemblGenomes-Tr:CAB15299" /db_xref="GOA:O32198" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR017202" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14134" /db_xref="UniProtKB/Swiss-Prot:O32198" /translation="MRKKMLASLQWRAIRMTTGISLLLFVCLISFMMFYYRLDPLVLL SSSWFGIPFILILLLISVTVGFASGYMYGNRLKTRIDTLIESILTFENGNFAYRIPPL GDDEIGLAADQLNEMAKRVELQVASLQKLSNERAEWQAQMKKSVISEERQRLARDLHD AVSQQLFAISMMTSAVLEHVKDADDKTVKRIRMVEHMAGEAQNEMRALLLHLRPVTLE GKGLKEGLTELLDEFRKKQPIDIEWDIQDTAISKGVEDHLFRIVQEALSNVFRHSKAS KVTVILGIKNSQLRLKVIDNGKGFKMDQVKASSYGLNSMKERASEIGGVAEVISVEGK GTQIEVKVPIFPEEKGENERDSSIID*" /label="liaS CDS" gene complement(2899115..2900197) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /label="liaS gene" CDS complement(2900194..2900919) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane component associated to the LiaRS two-component system" /protein_id="NP_391190.1" /db_xref="EnsemblGenomes-Gn:BSU33100" /db_xref="EnsemblGenomes-Tr:CAB15300" /db_xref="GOA:O32199" /db_xref="InterPro:IPR016975" /db_xref="InterPro:IPR024425" /db_xref="SubtiList:BG14135" /db_xref="UniProtKB/Swiss-Prot:O32199" /translation="MTKKQLLGLIIALFGISMFLQIIGIGDLLFWPLFFLIAGYFLKK YSRDWLGSVMYIFAAFLFLKNLFSITFNLFGYAFAAFLIYAGYRLIKGKPIFEPNEKQ VNLNKKEHHEPPKDVKHPDMRSFFIGELQMMKQPFDLNDLNVSGFIGDIKIDLSKAMI PEGESTIVISGVIGNVDIYVPSDLEVAVSSAVFIGDINLIGSKKSGLSTKVYAASTDF SESKRRVKVSVSLFIGDVDVKYV*" /label="liaF CDS" gene complement(2900194..2900919) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /label="liaF gene" CDS complement(2900953..2901825) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="sensor of antibiotic stress on the cell wall" /protein_id="NP_391191.2" /db_xref="EnsemblGenomes-Gn:BSU33110" /db_xref="EnsemblGenomes-Tr:CAB15301" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14136" /db_xref="UniProtKB/Swiss-Prot:O32200" /translation="MKKMLGKLLITAGILVFFAVVVKDVFAAGLGFINGTEADSASAS PRDIDSMVIESDSKDVRIIAEERSDISAGISGDSGKLFVTENKRKLELTVKEKEFQFL NGFNRSTLIVRLPYDYKGDLAVRTSSGDVSVAGNDHLALSGLNAVSASGNTSVTDVRI QDLKVKASSGDVSISNTVSKTAGIDLASGDANLVHVSGSLDVKMTSGDFNAVLKKVTG PVSVTLTSGDANVSLPQNGSFAVNALSASGDVSSPYSFADKGHKEQHHITGTQGSGRH PIDIKTDSGDLAIR*" /label="liaG CDS" gene complement(2900953..2901825) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /label="liaG gene" promotor_-10 complement(2901844..2901863) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2901864) /Source="Nicolas_upshifts" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2901878..2901881) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2901926..2902603) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23874669, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23874669, 24666271, 28546427; Product type f: factor" /codon_start=1 /transl_table=11 /product="modulator of liaIHGFSR (yvqIHGFEC) operon expression" /protein_id="NP_391192.1" /db_xref="EnsemblGenomes-Gn:BSU33120" /db_xref="EnsemblGenomes-Tr:CAB15302" /db_xref="GOA:O32201" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG14137" /db_xref="UniProtKB/Swiss-Prot:O32201" /translation="MVLKRIRDMFVASVHEGLDKMENPKVMLNQYVRDMESDIAKAKQ TIVKQHTIAYQFKKKYEEAAEVAGKRKNQAQLAFDAGEEELAKKALTEMKYLEGKAAE HKASYEQANSQLADLKEQLAALETKLQDVKDKKQALIARANAAKAKEHMNTTFDKIDS ESAYREFLRIENRIEEMEIRANYSKSAEAGTELTRKEFADDVEAEIEKMRTLSLQKSD QTKAANE*" /label="liaH CDS" gene complement(2901926..2902603) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /label="liaH gene" downshifts complement(2901942) /Source="Nicolas_upshifts" /id="D1710" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="3.84852" /MaxDrop="3.1352" /score="-8.3477012" /energy="-4.5" /TU="U2597" /idTUdmin="U2598" /TUdmin=1243 /isTUend="FALSE" /label="downshifts" CDS complement(2902630..2903010) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427; Product type s: structure" /codon_start=1 /transl_table=11 /product="membrane anchor for the phage-shock protein A homolog LiaH" /protein_id="NP_391193.1" /db_xref="EnsemblGenomes-Gn:BSU33130" /db_xref="EnsemblGenomes-Tr:CAB15303" /db_xref="GOA:O32202" /db_xref="SubtiList:BG14138" /db_xref="UniProtKB/Swiss-Prot:O32202" /translation="MKINKKTIGGFLLIVFGISVFFGGGSFGFIIPLAIGSLMTYAGI KRFAAGKTITGIIVGGIGAIMLICSLPFVVGIALAAAMVYYGWKLMKNGSADNGVSSF DPEPASAAYQSHFDDEWEEFLKKK*" /label="liaI CDS" gene complement(2902630..2903010) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /label="liaI gene" promotor_-10 complement(2903033..2903052) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2903053) /Source="Nicolas_upshifts" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2903067..2903070) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2903172..2904440) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15273097, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux protein" /protein_id="NP_391194.1" /db_xref="EnsemblGenomes-Gn:BSU33140" /db_xref="EnsemblGenomes-Tr:CAB15304" /db_xref="GOA:O32203" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14139" /db_xref="UniProtKB/Swiss-Prot:O32203" /translation="MVNLIESDSIWKRNFNYLFFSRIVKISGDMFAFNSILWFLIYDG KGAIGTALLIAVTFLPEAVLAPVTGPFMKQTTLKFWMYFSDLTRAAIVLIIPLCHFAG FSPLWFVMTLMIVHSATGAAYNPASIALIPQIVNEQGIQKANAVLQSSAQIVRLGAVT LCGAFLTFISPSYTMLIALVLYLVSGFLVLFIKYTAVESQSESAVVTQRGTYIGRLKR GFRLVRKHQILYPLAIYCIFMNFAAAPWEALSAVYVAEDLNGQPIVYSLLKATTAAGA FLLGFVLAKVKVNRYGLLFVTAGIIEGFAFFITGMNTFLPLVFFAAFTFGAAVSAVNV PEYTIIQTSVDSEDQPQVYAVIHMISNISIPAGAVICGYAANAFGSGKVIAVGGIVEI IAGIGILLFTKLAKAERSDLIKEREASVHL*" /label="yvqJ CDS" gene complement(2903172..2904440) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /label="yvqJ gene" downshifts complement(2903185) /Source="Nicolas_upshifts" /id="D1711" /incds=0 /nref=78 /ntot=164 /MaxReadThrough="0.70612" /MaxDrop="4.80625" /score="32.7496145" /energy="-12.9" /TU="NA" /idTUdmin="U2598" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2904474..2904493) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2904485) /Source="Nicolas_upshifts" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2904508..2904515) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2904611) /Source="Nicolas_upshifts" /id="D1712" /incds=0 /nref=33 /ntot=211 /MaxReadThrough="1.54601" /MaxDrop="4.92923" /score="51.1311697" /energy="-17.1" /TU="NA" /idTUdmin="U2599" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(2904617..2905198) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /EC_number="2.5.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12869542, 14704351, 17588214, 19933577, 21514283; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP:cob(I)alamin adenosyltransferase" /protein_id="NP_391195.2" /db_xref="EnsemblGenomes-Gn:BSU33150" /db_xref="EnsemblGenomes-Tr:CAB15305" /db_xref="GOA:O34899" /db_xref="InterPro:IPR016030" /db_xref="InterPro:IPR029499" /db_xref="InterPro:IPR036451" /db_xref="PDB:1RTY" /db_xref="SubtiList:BG14140" /db_xref="UniProtKB/Swiss-Prot:O34899" /translation="MKLYTKTGDKGQTGLVGGRTDKDSLRVESYGTIDELNSFIGLAL AELSGQPGFEDLTAELLTIQHELFDCGGDLAIVTERKDYKLTEESVSFLETRIDAYTA EAPELKKFILPGGSKCASLLHIARTITRRAERRVVALMKSEEIHETVLRYLNRLSDYF FAAARVVNARSGIGDVEYERSAIVFRDRNSSES*" /label="yvqK CDS" gene complement(2904617..2905198) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /label="yvqK gene" CDS complement(2905221..2906549) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 transport system, ATPase component" /protein_id="NP_391196.1" /db_xref="EnsemblGenomes-Gn:BSU33160" /db_xref="EnsemblGenomes-Tr:CAB15306" /db_xref="GOA:O34631" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14141" /db_xref="UniProtKB/Swiss-Prot:O34631" /translation="MKAEGLSGGYGDSRLINNVSLTVEKGEFLGILGPNGSGKTTLLH LLTGTLPAKKGRVYLAGKLLADYKPKELAQIMAVLPQKMDQAFTFTVEETVAFGRYPF QTGLFRQQTEKGEAIVQEAMEQTGVADFAQKPIRELSGGEQQRVYLAQALAQQPRILF LDEPTNFLDLAYQKDLLDLIKRLTRESGLAAVSVFHDLNTASLYCDGLMFMKNGTAGP KQKPEYAVTEQSIKAVYDTDVTALVHQSSPKPMIVIQPEKDSVKRQSIPFEALLQAGR DDILLQTEIPLRTLSSTPIGAGFSWSRTLIHKRLPDQPDPIEGLTACLSESGFQLQET CAMASSERLDRFVYRTYEDGELSVFICVQTGFSIWILINGYAADQFFIKALMAAEAER TKVLGDGGGTGDILIAATQTQQSENIEQRLNQLIKKGTAECIKEAAELFE*" /label="yvrA CDS" gene complement(2905221..2906549) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /label="yvrA gene" CDS complement(2906549..2907610) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 15849754, 16850406, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 permease" /protein_id="NP_391197.1" /db_xref="EnsemblGenomes-Gn:BSU33170" /db_xref="EnsemblGenomes-Tr:CAB15307" /db_xref="GOA:O34451" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG14142" /db_xref="UniProtKB/Swiss-Prot:O34451" /translation="MRKAFTRIRLRNNRYAAYIIGFSFLAVSIILGISCGSLHIPIPA VFRVFWHQGFGGSIGSDDPMYTNIMMNIRLPRVVLAALVGAALSIAGAAFQGLLKNPL ADPYTLGVSSGASVGAVVTLFLGLHLPVIGGFTLPVLSVAAALATMAAVLFFSRLVHA SMSVSTLILTGVITNSFLGAFISLIIALTGDNLLPIVHWLLGSVSMRGWSYVILFLPF FLLGTILLIINGRELNVMTYGEDKAKLLGVSVQQRKMMILIAGSLLTGSAVAVSGTIG FVGLVIPHITRLLWGTDHRHLLPLSALLGAGFLVLADLLSRTIIEPIELPIGIITSLA GAPVFALILIRQHRGGRSL*" /label="yvrB CDS" gene complement(2906549..2907610) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /label="yvrB gene" CDS complement(2907573..2908517) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative lipoprotein binding vitamin B12" /protein_id="NP_391198.1" /db_xref="EnsemblGenomes-Gn:BSU33180" /db_xref="EnsemblGenomes-Tr:CAB15308" /db_xref="GOA:O34805" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG14143" /db_xref="UniProtKB/Swiss-Prot:O34805" /translation="MKKRAGIWAALLLAAVMLAGCGNPADQKDSKAKQKTEVFPVTID DASNQDVTIKKEPKKIVSLMPSNTEITYALGLGDKVVGVTTNDTYPKEVKKVEKVGDM NVNVEKVISLKPDLVLAHESSMSASADAIKQLKDAGITVLTVNDAQSFSEVYKSIEMI GEAGGAEKKADQLVKSMKSDLKDIQEKAKTISKDEEKSVFIEVSPDPDIYTTGKDTFM NEMLNVIHAKNAAADQTGWVQMTDEAIVKLNPDAIVTTDGVKAKAVEKRDGWSEINAV KHHRVYDVDPDLVTRSGPRLIEGVEELAESIYPDTFKE*" /label="yvrC CDS" gene complement(2907573..2908517) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /label="yvrC gene" S_feature complement(2908518..2908787) /Source="Nicolas_S_feature" /locus_tag="new_3404438_3404707_c" /HighExp="LBGtran, LBGexp, Etha, LPh, S3, Lbexp, G180, dia0, HPh, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.956, 1" /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1276" misc_RNA complement(2908626..2908756) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /product="putative coenzyme B12 (AdoCbl) riboswitch" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 17038623, 21140903, 25917914; Product type n: RNA" /function="16.3: Control" /label="srbL RNA" gene complement(2908626..2908756) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /label="srbL gene" promotor_-10 complement(2908764..2908783) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2908787) /Source="Nicolas_upshifts" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2908789..2909716) /Source="Nicolas_S_feature" /locus_tag="new_3404709_3405636_c" /HighExp="Etha, B60, Sw, M9-stat, B36, C30, C90, Salt, G135, Gly" /AntisenseName="yvrD" /AntisenseCor="1.5286196477289399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1277" promotor_-35 complement(2908799..2908806) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2908849..2908856 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2908871..2908890 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2908875 /Source="Nicolas_upshifts" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="upshifts" CDS 2908915..2909706 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9922248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391199.1" /db_xref="EnsemblGenomes-Gn:BSU33190" /db_xref="EnsemblGenomes-Tr:CAB15309" /db_xref="GOA:O34782" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14144" /db_xref="UniProtKB/Swiss-Prot:O34782" /translation="MDLQLKEKLVLITGSTSGIGKAAAKSFLQEGAAVIVNGRKQETV DRTIEELSGYGTVHGAAADLSKTDEAAAFIEKVNEIGDIDILVNNLGFFEVKDFADVT DEEWNQYFEVNVMSAVRTSRHFLPKMLAKNSGRILNIASEAGVKPLPTMIPYSMTKTA LISLSRGMAEMTKGTNVTVNSVLPGPTWTEGVASYMEGAAQAAGQDTDTFIKDYFKVN EPTSLIQRYATAEEVANTIVFLASDAASAINGTAQRVEGGIIRSL*" /label="yvrD CDS" gene 2908915..2909706 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /label="yvrD gene" downshifts 2909577 /Source="Nicolas_upshifts" /id="D1713" /incds=1 /nref=2 /ntot=89 /MaxReadThrough="6.202" /MaxDrop="3.35017" /score="36.8938178" /energy="-12" /TU="U2600" /idTUdmin="U2600" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 2909687 /Source="Nicolas_upshifts" /id="D1714" /incds=0 /nref=105 /ntot=218 /MaxReadThrough="2.44739" /MaxDrop="6.33457" /score="36.8938178" /energy="-12" /TU="NA" /idTUdmin="U2600" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2909744..2910622) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar lactone lactonase" /protein_id="NP_391200.1" /db_xref="EnsemblGenomes-Gn:BSU33200" /db_xref="EnsemblGenomes-Tr:CAB15310" /db_xref="GOA:O34940" /db_xref="InterPro:IPR005511" /db_xref="InterPro:IPR011042" /db_xref="InterPro:IPR013658" /db_xref="SubtiList:BG14145" /db_xref="UniProtKB/Swiss-Prot:O34940" /translation="MDAVLEADTRAVIGEGPLWDEENGRLYWVDILGSELHIFDPEEK INRSIKFKSFVTALAKYSKDELIMTMKDGFYLYHLRDDSLEKIKQPKDMHESLRFNDA KCDPYGRLWAGTTSMEGEQKQASLYRLNLDGSLVKIKDQVSTSNGLDWDRERNLMYYI DTPTQEIVRYSYDPQSGDVSNPEPVYRFDQSDGLPDGMTIDQNGMLWVALFGGSRVVH IDPFQKKEINSISVPAKYVTCCAFGGRDLKTLYITTATEQMTEKERYEQPHAGGLFSA QLETGGYQPVPFAGDV*" /label="yvrE CDS" gene complement(2909744..2910622) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /label="yvrE gene" downshifts complement(2909761) /Source="Nicolas_upshifts" /id="D1715" /incds=0 /nref=31 /ntot=260 /MaxReadThrough="7.17016" /MaxDrop="5.74101" /score="29.8014794" /energy="-12" /TU="U2601" /idTUdmin="U2602" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2910646..2910664) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2910665) /Source="Nicolas_upshifts" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2910678..2910684) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2910694..2912436) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrH)]" /protein_id="NP_391201.2" /db_xref="EnsemblGenomes-Gn:BSU33210" /db_xref="EnsemblGenomes-Tr:CAB15311" /db_xref="GOA:O34989" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14146" /db_xref="UniProtKB/Swiss-Prot:O34989" /translation="MRLRWKFLFHFFGQMLIVILLLTVMLVASFFYLDARFSDAESNS GLTKATTDTLEAYLDVNEDGTWEVDNFLKKSVDKQHGWMQIIDSEGNTDYSYGVPKDV PGTYTKKELLSIYKTKKLHNYKLNYWAINIEDKSYLLLSGWKSKSEQLLTSVEKREQK IDSLAHYKSSTIDYIKRKKGAIYLLDSNGKILDSINSTKSERKTMNQLELLKYSSKPW NYKREISVKILNKDRWMVATVPNPVYVTDQEFNKSFLKVVLKAMFLVMAVLFMYIIWM TVWYMFRFGLPIFHTIRWLVNLSKGKLEEPRNREGRPVSKNKKGKIKQPYRFFGEIFE SMDQLTETLRRDKRNREKIQATREEWIAGLSHDLKTPLSSIYGYSMMLESKQYDWSPE EVKEMGQVVREKSEYMSKLIEDLNLTYRLKNDALPIERKLTSLIPFFKNVIEDFKKNP FSEGYDISFVSKEEHIEFALDEAWFRRILENLLGNAVKHNGKGTEIQVILEQTKNHIS LKVKDNGKGMDEETITHLFNRYYRGTNTKDSTAGTGLGLAIAKELVHLHNGTIHVNSR TNIGTVITILFKKQ*" /label="yvrG CDS" gene complement(2910694..2912436) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /label="yvrG gene" CDS complement(2912433..2913146) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrG)]" /protein_id="NP_391202.2" /db_xref="EnsemblGenomes-Gn:BSU33221" /db_xref="EnsemblGenomes-Tr:CAB15312" /db_xref="GOA:P94504" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12452" /db_xref="UniProtKB/Swiss-Prot:P94504" /translation="MENASILIVDDEKAIVDMIKRVLEKEGYRNILDAASAEEAIPVV KANKVDLIVLDVMMGGMSGFEACTLIREYSDAPIFFLTARSSDADKLSGFAVGADDYI TKPFNPLELAARIRAHLKRTYQSKETSSNQTYTYDYFTFSPQNAELIVGGEAVACSAQ LLQLLQYFCEHPNVVLSKDQIYEKVWGYPSYGDNNTVMVHIRKLREKIERDPSNPEYI VTVRGLGYRFIPNPEGKRS*" /label="yvrH CDS" gene complement(2912433..2913146) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /label="yvrH gene" misc_feature complement(2913177..2913196) /Source="Nicolas_upshift_promotors" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2913195) /Source="Nicolas_upshifts" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="upshifts" CDS complement(2913299..2913538) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sigma-O" /protein_id="YP_003097787.1" /db_xref="EnsemblGenomes-Gn:BSU33222" /db_xref="EnsemblGenomes-Tr:CAX52693" /db_xref="GOA:C0H3R4" /db_xref="UniProtKB/Swiss-Prot:C0H3R4" /translation="MDGQFEQKKKQKDETYDIEHLIACFSPMIRKKLSNTSYQEREDL EQELKIKMFEKADMLLCQDVPGFWEFILYMVDENS*" /label="rsoA CDS" gene complement(2913299..2913538) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /label="rsoA gene" downshifts complement(2913306) /Source="Nicolas_upshifts" /id="D1716" /incds=0 /nref=4 /ntot=30 /MaxReadThrough="2.45068" /MaxDrop="3.82244" /score="12.6471586" /energy="-8.2" /TU="NA" /idTUdmin="U2605" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2913534..2913552) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2913542..2914072) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16306698, 18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16306698, 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="alternative sigma factor" /protein_id="NP_391203.2" /db_xref="EnsemblGenomes-Gn:BSU33230" /db_xref="EnsemblGenomes-Tr:CAB15313" /db_xref="GOA:O34843" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14147" /db_xref="UniProtKB/Swiss-Prot:O34843" /translation="MKHPIVKHFLSNPQHYRLFKNVMESPNEKDARSLDELFKQFYKE IRIVKYMNSMIRIFSIDFDKRVRKNQKRYPLTVDHPEAGDRLSSETGSDAFEEFLDRQ DDLSQHVQDYQLYQAIQKLTDKQKSVLTKVYLHGATMQEIADSLGESRQNISNIHKKG LENIRKQLAAQKKGEK*" /label="sigO CDS" gene complement(2913542..2914072) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /label="sigO gene" upshifts complement(2913543) /Source="Nicolas_upshifts" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2913567..2913573) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2914075..2914094) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2914082) /Source="Nicolas_upshifts" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="upshifts" CDS 2914087..2914425 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in oxalate decarboxylase expression" /protein_id="YP_003097788.1" /db_xref="EnsemblGenomes-Gn:BSU33239" /db_xref="EnsemblGenomes-Tr:CAX52694" /db_xref="InterPro:IPR024419" /db_xref="UniProtKB/Swiss-Prot:C0H3R5" /translation="MTVKDFDSPSNRLPTKLNEGKQKKVNYYFPPSVFQNTLQQFTFY RFSSLTYMTAEKEGRYFPMDQVFIEEVVKQIGNLGFPALIAMYLLTRFEKKFDQLIEL MTELKDHAKK*" /label="yvrJ CDS" gene 2914087..2914425 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /label="yvrJ gene" promotor_-35 complement(2914109..2914116) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2914125..2914144) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2914137) /Source="Nicolas_upshifts" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2914159..2914165) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2914171..2914271 /Source="Nicolas_upshift_promotors" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="promotor_no_box" upshifts 2914231 /Source="Nicolas_upshifts" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="upshifts" promotor_no_box 2914399..2914499 /Source="Nicolas_upshift_promotors" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 2914459..2914545 /Source="Nicolas_S_feature" /locus_tag="new_3410379_3410465" /HighExp="T5.0H, T4.0H, T3.30H, Lbstat, T3.0H, nit, T2.0H, T2.30H, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.317" /TUlongSig="Sig-" /TUlongPSig="0.278" /label="S1278" upshifts 2914459 /Source="Nicolas_upshifts" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="upshifts" CDS 2914546..2915703 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase" /protein_id="NP_391204.1" /db_xref="EnsemblGenomes-Gn:BSU33240" /db_xref="EnsemblGenomes-Tr:CAB15314" /db_xref="GOA:O34714" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="PDB:1J58" /db_xref="PDB:1L3J" /db_xref="PDB:1UW8" /db_xref="PDB:2UY8" /db_xref="PDB:2UY9" /db_xref="PDB:2UYA" /db_xref="PDB:2UYB" /db_xref="PDB:2V09" /db_xref="PDB:3S0M" /db_xref="PDB:4MET" /db_xref="PDB:5HI0" /db_xref="SubtiList:BG14148" /db_xref="UniProtKB/Swiss-Prot:O34714" /translation="MKKQNDIPQPIRGDKGATVKIPRNIERDRQNPDMLVPPETDHGT VSNMKFSFSDTHNRLEKGGYAREVTVRELPISENLASVNMRLKPGAIRELHWHKEAEW AYMIYGSARVTIVDEKGRSFIDDVGEGDLWYFPSGLPHSIQALEEGAEFLLVFDDGSF SENSTFQLTDWLAHTPKEVIAANFGVTKEEISNLPGKEKYIFENQLPGSLKDDIVEGP NGEVPYPFTYRLLEQEPIESEGGKVYIADSTNFKVSKTIASALVTVEPGAMRELHWHP NTHEWQYYISGKARMTVFASDGHARTFNYQAGDVGYVPFAMGHYVENIGDEPLVFLEI FKDDHYADVSLNQWLAMLPETFVQAHLDLGKDFTDVLSKEKHPVVKKKCSK*" /label="oxdC CDS" gene 2914546..2915703 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /label="oxdC gene" downshifts 2915689 /Source="Nicolas_upshifts" /id="D1717" /incds=0 /nref=11 /ntot=87 /MaxReadThrough="4.83038" /MaxDrop="4.39135" /score="2.61432951" /energy="-9.4" /TU="U2607" /idTUdmin="U2607" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS 2915764..2916174 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18573182, 19047353, 26651345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18573182, 19047353, 26651345; Product type f: factor" /codon_start=1 /transl_table=11 /product="acid stress-sensitive anti sigma factor" /protein_id="NP_391205.1" /db_xref="EnsemblGenomes-Gn:BSU33250" /db_xref="EnsemblGenomes-Tr:CAB15315" /db_xref="GOA:O34686" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14149" /db_xref="UniProtKB/Swiss-Prot:O34686" /translation="MKHQNPSKRLLRLSIKYLLAAAAVVLTYFAVIYILFSLAGTSYR SAAHVLLFAVVFLVLGLCFEPFERLMIHSFTFFKTGKRLFILLAGIVQLLFLWMTAHT TDQLISDIWLSTTEEMIVAAVFLILDKCNSALPS*" /label="rsiO CDS" gene 2915764..2916174 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /label="rsiO gene" downshifts 2916173 /Source="Nicolas_upshifts" /id="D1718" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.57216" /MaxDrop="3.72691" /score="-9.50136752" /energy="-7.4" /TU="NA" /idTUdmin="U2607" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2916208..2917437) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391207.3" /db_xref="EnsemblGenomes-Gn:BSU33260" /db_xref="EnsemblGenomes-Tr:CAB15317" /db_xref="GOA:P46324" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG11368" /db_xref="UniProtKB/Swiss-Prot:P46324" /translation="MLEHIRISFQSIFSHKLRSILTMLGVIIGIAAIIAIVSMLKGQS EQLKQSMIGMGNNAINVVYQPSGGEEESGGPQVSYASAPPVAEETVKAIKSDPMVKGL SLYYLSEGASVFHLTNVSYPQVYGVDDDYFDMFPIRITEGRKLTENDLNSTHQVVMIN EAVRDELFPDGEALHKSIEMNGVPFKVVGVFKEKNQQESMFEGDYANPVLYVPKKVWP LIEGFDAPTQIAVQADSSEHIQEAGVMAADLLNQGLSEAELEKAEYSVMDLQEIAQEV ESFNQSFALLLGGIASISLLVGGIGVMNIMLVSVTERTREIGIKKALGAKRRVILFQF LTEAVVLTSIGGILGVLAGFGIAKLLTVIFPMPFIVSIPAVVGALIFSMAVGIIFGLL PSIKASKLQPVDALRYE*" /label="yvrN CDS" gene complement(2916208..2917437) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /label="yvrN gene" downshifts complement(2916225) /Source="Nicolas_upshifts" /id="D1719" /incds=0 /nref=10 /ntot=218 /MaxReadThrough="2.36812" /MaxDrop="4.29282" /score="13.74435" /energy="-11.3" /TU="NA" /idTUdmin="U2608" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" CDS complement(2917430..2918119) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544226, 22517742; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391208.2" /db_xref="EnsemblGenomes-Gn:BSU33270" /db_xref="EnsemblGenomes-Tr:CAB15318" /db_xref="GOA:O34979" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14151" /db_xref="UniProtKB/Swiss-Prot:O34979" /translation="MLTLNNISKSYKLGKEEVPILKHINLTVQAGEFLAIMGPSGSGK STLMNIIGCLDRPTSGTYTLDQIDILKGKDGALAEIRNESIGFVFQTFHLLPRLTALQ NVELPMIYNKVKKKERRQRAYEALEKVGLKDRVSYKPPKLSGGQKQRVAIARALVNQP RFILADEPTGALDTKSSEQILALFSELHREGKTIIMITHDPDVAKKADRTVFIRDGEL VLDERGDISHA*" /label="yvrO CDS" gene complement(2917430..2918119) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /label="yvrO gene" CDS complement(2918103..2919296) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter membrane fusion component" /protein_id="NP_391209.1" /db_xref="EnsemblGenomes-Gn:BSU33280" /db_xref="EnsemblGenomes-Tr:CAB15319" /db_xref="GOA:O35007" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG14152" /db_xref="UniProtKB/Swiss-Prot:O35007" /translation="MSKKKKWLIGGAICAGVLVLAGIGAGGFYFFTHMNQVAVSSEPY AESVAVYMGGDSESGQTFSGKVEPEKQQKVYIDSEKGSIKKTYVKEGDQVKKGDKLFE YEGEDHSDEVEQANLQIEMTNLQINRLQKSITETEKKLKVAGKEEKNQLQDELDQTNF DLKTSQLELKQHQKELAGLTKNKGSNVITSKHDGIVQSVNQDIADGATGDQAAGPYIQ IVSTGKYLVKSQINELLMDTIKKGSKVRVTLKTGGEGEWKGKVTSIGKLPAGAGEGEE SESFADEEMNPQSSNYPFTILLDSHKGLEVGYHVNIEVMSDNADADTIKLPSDMVIQD DGEPYVWKADENHKAVKQPVEIGETDENDMVEIKSGLTPEDYVIYPDPAVKEGKQVTV NADTE*" /label="yvrP CDS" gene complement(2918103..2919296) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /label="yvrP gene" promotor_-10 complement(2919340..2919359) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2919353) /Source="Nicolas_upshifts" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2919374..2919381) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2919467..2920276) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ATP-binding protein)" /protein_id="NP_391210.1" /db_xref="EnsemblGenomes-Gn:BSU33290" /db_xref="EnsemblGenomes-Tr:CAB15335" /db_xref="GOA:P49938" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11390" /db_xref="UniProtKB/Swiss-Prot:P49938" /translation="MNSLSTEQLGIGYGDRVIVEDLNISIPKGKITTLIGPNGCGKST ILKTMSRIMRSHAGAVYLNGKAIHKMSTKDIAKDMAILPQTPEAPSGLTVHELVSYGR FPHQSGFGRLNDEDRRIIKWALEETGMAEYAERPIEALSGGQRQRVWIAMALAQGTEL LLLDEPTTYLDLAHQLEILQLLDRLNKEQGRTILMVIHDLNHAARFSHYMIALKKGTV IKEGTALEVMTPDILKQVFQIDAEIVTDPRTNKPVCLTYDLIKNEKELVTV*" /label="fhuC CDS" gene complement(2919467..2920276) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /label="fhuC gene" downshifts complement(2919484) /Source="Nicolas_upshifts" /id="D1720" /incds=0 /nref=190 /ntot=245 /MaxReadThrough="1.31294" /MaxDrop="6.48454" /score="40.5986253" /energy="-11" /TU="NA" /idTUdmin="U2610" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2919623..2919632 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2919645..2919664 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2919649 /Source="Nicolas_upshifts" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2920292..2921302) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251, 15849754, 16850406, 24362930; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391211.1" /db_xref="EnsemblGenomes-Gn:BSU33300" /db_xref="EnsemblGenomes-Tr:CAB15336" /db_xref="GOA:P49937" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11391" /db_xref="UniProtKB/Swiss-Prot:P49937" /translation="MKTKTNKPLIVMAVTFLLIVVVFFISLNLGVIKIAPLKTLQVFF GQGTARDELVLFEFRLPRIILSLLVGAGISVAGAILQSVSQNELAEPGILGINAGGSL AVVLFIYFFQGSASDLSFFGTFMLPFSALAGAILAAFLIYILAWKKGVTPIRLILVGI GVNAGFNALLLIFQLKMDPHDFMQAAVWISGSIWGANWNMIWAILPWIVILLLFTLYK ARYLNIMQLGDQLATGLGTAVEKERRILLLAAVTLAASCVAAAGGIAFLGLIAPHVAR RLTGPRHQTLIPVSAFIGSFLFLLADTLARNVLAPSEIPVGLVISVLGAPYFIYLLMK AN*" /label="fhuG CDS" gene complement(2920292..2921302) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /label="fhuG gene" CDS complement(2921302..2922456) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 15849754, 16850406, 24362930; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391212.1" /db_xref="EnsemblGenomes-Gn:BSU33310" /db_xref="EnsemblGenomes-Tr:CAB15337" /db_xref="GOA:P49936" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11389" /db_xref="UniProtKB/Swiss-Prot:P49936" /translation="MHFHFCSKHSIKSAEKSDILKQQLIIIISNRKEVRQLSQHKNIR TASEEIQWTSRTYGAVIVLIAGLCLLCLGAFLSISLGAADIHLRTVWEAIFHYQPTKT SHQIIHDLRLPRTAAAALVGALLAVSGAIMQGMTRNPLAEPSIMGVTSGSAFAVSIAF AFFPGLSAMGLVLWSFAGAGLGASTVMGIGMFSRGGLTPVKLALAGTAVTYFFTGIST AIAIRFDVAQDISFWYAGGVAGVKWSGVQLLLIAGAVGLTLAFFIARSVTVLSLGDDL AKGLGQYTSAVKLVGMLIVVILTGAAVSIAGTIAFIGLIIPHITRFLVGVDYRWIIPC SAVLGAVLLVFADIAARLVNAPFETPVGALTSLIGVPFFFYLARRERRGL*" /label="fhuB CDS" gene complement(2921302..2922456) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /label="fhuB gene" promotor_-10 complement(2922389..2922408) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2922406) /Source="Nicolas_upshifts" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2922420..2922427) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2922468..2922475 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2922490..2922509 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2922499 /Source="Nicolas_upshifts" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2922554..2923501 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 26919525; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ferrichrome-bindinglipoprotein)" /protein_id="NP_391213.1" /db_xref="EnsemblGenomes-Gn:BSU33320" /db_xref="EnsemblGenomes-Tr:CAB15338" /db_xref="GOA:P37580" /db_xref="InterPro:IPR002491" /db_xref="PDB:3G9Q" /db_xref="PDB:3HXP" /db_xref="SubtiList:BG10828" /db_xref="UniProtKB/Swiss-Prot:P37580" /translation="MTHIYKKLGAAFFALLLIAALAACGNNSESKGSASDSKGAETFT YKAENGNVKIPKHPKRVVVMADGYYGYFKTLGINVVGAPENVFKNPYYKGKTNGVENI GDGTSVEKVIDLNPDLIIVWTTQGADIKKLEKIAPTVAVKYDKLDNIEQLKEFAKMTG TEDKAEKWLAKWDKKVAAAKTKIKKAVGDKTISIMQTNGKDIYVFGKDFGRGGSIIYK DLGLQATKLTKEKAIDQGPGYTSISLEKLPDFAGDYIFAGPWQSGGDDGGVFESSIWK NLNAVKNGHVYKMDPIGFYFTDPISLEGQLEFITESLTK*" /label="fhuD CDS" gene 2922554..2923501 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /label="fhuD gene" downshifts 2923477 /Source="Nicolas_upshifts" /id="D1721" /incds=0 /nref=168 /ntot=245 /MaxReadThrough="3.82329" /MaxDrop="5.73183" /score="11.0136807" /energy="-12.1" /TU="U2611" /idTUdmin="U2611" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts 2923521 /Source="Nicolas_upshifts" /id="D1722" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="3.01143" /MaxDrop="4.08479" /score="11.0136807" /energy="-12.1" /TU="NA" /idTUdmin="U2611" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts 2923675 /Source="Nicolas_upshifts" /id="D1723" /incds=0 /nref=8 /ntot=87 /MaxReadThrough="0.219110000000001" /MaxDrop="3.67928" /score="7.53231618" /energy="-13.7" /TU="NA" /idTUdmin="U2611" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(2923736..2925145) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14627808, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lysine permease" /protein_id="NP_391214.1" /db_xref="EnsemblGenomes-Gn:BSU33330" /db_xref="EnsemblGenomes-Tr:CAB15339" /db_xref="GOA:O32204" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG14154" /db_xref="UniProtKB/Swiss-Prot:O32204" /translation="MEQTKKWGFWLLTAFVVGNMVGSGIFSLPSSLASIASPFGATSA WLLTGAGVLMIALVFGHLSIRKPELTAGPQSYARALFSDPKKGNAAGFTMVWGYWVAS WISNVAIITSLAGYLTSFFPILVDKREMFSIGGQEVTLGQLLTFAVCTILLWGTHAIL VASINGASKLNFVTTLSKVLGFVFFIVAGLFVFQTSLFGHFYFPVQGENGTSIGIGGQ VHNAAISTLWAFVGIESAVILSGRARSQRDVKRATITGLLIALSIYIIVTLITMGVLP HDKLVGSEKPFVDVLYAIVGNAGSVIMALLAILCLFGTMLGWILLGSEVPYQAAKAGD FPAFFAKTNKKGSPVIALIITNVMSQVFIFSVISRTISDAFTFLTTAATLAYLIPYLV SAIYSLKVVIKGETYDQLKGSRVRDGLIAILACAYSVFVIVTGTADLTTFILGIGLFF VGLIVYPFVSNKFQKEKQA*" /label="lysP CDS" gene complement(2923736..2925145) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /label="lysP gene" downshifts complement(2923751) /Source="Nicolas_upshifts" /id="D1724" /incds=0 /nref=168 /ntot=213 /MaxReadThrough="0.441040000000001" /MaxDrop="6.03347" /score="23.064706" /energy="-13.7" /TU="NA" /idTUdmin="U2613" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2924563..2924567 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2924585..2924601 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2924592 /Source="Nicolas_upshifts" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="upshifts" S_feature 2924599..2925566 /Source="Nicolas_S_feature" /locus_tag="new_3420519_3421486" /HighExp="S3, S4, S7, S5, S8, S6, Etha, M9-stat, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="7.6401427420847101E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.4" /TUlongSig="NA" /TUlongPSig="NA" /label="S1279" downshifts complement(2925247) /Source="Nicolas_upshifts" /id="D1725" /incds=0 /nref=1 /ntot=43 /MaxReadThrough="5.98281" /MaxDrop="3.61093" /score="-2.14086757" /energy="-5" /TU="U2613,U2614" /idTUdmin="U2614" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" misc_RNA complement(2925249..2925428) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22416067; Product type n: RNA" /label="kswB RNA" gene complement(2925249..2925428) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /label="kswB gene" promotor_-10 complement(2925458..2925475) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2925469) /Source="Nicolas_upshifts" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2925490..2925497) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2925523 /Source="Nicolas_upshifts" /id="D1726" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.6441" /MaxDrop="3.53891" /score="-0.527038766" /energy="-4.8" /TU="U2612" /idTUdmin="U2612" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(2925545..2925685) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054593.1" /db_xref="EnsemblGenomes-Gn:BSU33340" /db_xref="EnsemblGenomes-Tr:CAE01467" /db_xref="GOA:Q7WY58" /db_xref="InterPro:IPR014220" /db_xref="SubtiList:BG14174" /db_xref="UniProtKB/Swiss-Prot:Q7WY58" /translation="MGFFNKDKGKRSEKEKNVIQGALEDAGSALKDDPLQEAVQKKKN NR*" /label="sspJ CDS" gene complement(2925545..2925685) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /label="sspJ gene" downshifts complement(2925555) /Source="Nicolas_upshifts" /id="D1727" /incds=0 /nref=40 /ntot=87 /MaxReadThrough="4.06523" /MaxDrop="5.5784" /score="-1.94521013" /energy="-14.5" /TU="U2614" /idTUdmin="U2614" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" upshifts complement(2925713) /Source="Nicolas_upshifts" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="upshifts" S_feature complement(2925715..2926303) /Source="Nicolas_S_feature" /locus_tag="new_3421635_3422223_c" /HighExp="S6, S8, S7, S5, BT, G135, Diami, G180, LBGstat, S4" /AntisenseName="yvsG" /AntisenseCor="0.46604658967097301" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1280" promotor_-10 complement(2925718..2925729) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-10" promotor_-35 complement(2925743..2925749) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-35" promotor_-35 2925775..2925782 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2925796 /Source="Nicolas_upshifts" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2925798..2925817 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2925852..2926334 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_391215.1" /db_xref="EnsemblGenomes-Gn:BSU33350" /db_xref="EnsemblGenomes-Tr:CAB15340" /db_xref="GOA:O32205" /db_xref="InterPro:IPR007404" /db_xref="InterPro:IPR016956" /db_xref="SubtiList:BG14153" /db_xref="UniProtKB/Swiss-Prot:O32205" /translation="MTGKTHIMGGIASCTAAAYYYGFDPVLMAASGAVGALIPDICHT QSKIGRKFPILSKVVSSVFGHRTFTHSLLFMLIMFFITSTYIPDKNISAGLMIGMASH LILDAWTVNGIKLLFPSTIRVRLPLYMKTGSFSEQLVLAGLTLASCYYFYMLFHGRMF *" /label="yvsG CDS" gene 2925852..2926334 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /label="yvsG gene" promotor_-35 2926348..2926355 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2926369..2926388 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2926381 /Source="Nicolas_upshifts" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2926434..2928287 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="primase of polyglycerolphosphate lipoteichoic acid (LTA) synthesis" /protein_id="NP_391216.1" /db_xref="EnsemblGenomes-Gn:BSU33360" /db_xref="EnsemblGenomes-Tr:CAB15341" /db_xref="GOA:O32206" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG14092" /db_xref="UniProtKB/Swiss-Prot:O32206" /translation="MKGTFFHNQRFLCFSILFMWIKTYVIYKLGFDLQIDTLLEELML LVNPLSFILPLFGIGLFLKENKQRAFLLIANLVLTVILISNTIFYGFYIDFITIPVLF QASNMSDMGSSVKELFHPLFIALFVDLVFLLLFARKTKHPQTKAAPHTIKRYYAASCG MLLCTLALAEVQQPKLLAHSFDREMLVKSIGLFQFHIYDTISQTVNISAKAFADEDSI TAIKNYTEADYSKPDQSKFGLAKGRNVIFVTLESTQSFVLNEKVNGKEITPFMNDLIK KSYSFDHFYQQTEQGKTSDSEFIVANSLYPSLSGAVFFTKSDHQFHTMYKSLKQHDYY SAVFHANHKTFWNRDVMYDTFGIDRFFDVDDFHVTPGTSTSWGLKDKEFLEQSAKKLK SLPQPFYSSFITLTNHFPFEIDEKDQLIDEFDSSSDLLNRYVTTVRYEDEALKHFIKK LKDEGLYENSMIVFMGDHYGISEAHNEAMAEFLGKDEITPYDNVQLQRVPFIIHIPGI TDQQPETIPDAGGQVDVRPTLMHLLGVETKGDIQFGNDLLSGDRTPFAVLRNGSFITN DYVYTKNTCYSQKTGEVLEDQDACLPYKEKANEELSLSDKILNGDLLRFSE*" /label="ltaSP CDS" gene 2926434..2928287 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /label="ltaSP gene" downshifts 2928273 /Source="Nicolas_upshifts" /id="D1728" /incds=0 /nref=30 /ntot=171 /MaxReadThrough="1.18268" /MaxDrop="3.6959" /score="21.1397957" /energy="-10.5" /TU="NA" /idTUdmin="U2615" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2928315..2929241) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative molybdate binding regulator" /protein_id="NP_391217.1" /db_xref="EnsemblGenomes-Gn:BSU33370" /db_xref="EnsemblGenomes-Tr:CAB15342" /db_xref="GOA:O32207" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010093" /db_xref="InterPro:IPR024370" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14093" /db_xref="UniProtKB/Swiss-Prot:O32207" /translation="MNETSSYTIEEVAGLLKVSKLTVYDLIKKGVLPAYRVGRQMRVD EEDLKQYKTNMRMSQPIAAKEAPKQVQEAEPDGRPNVMISGQDISMDILSKHLENAIQ ETPLRKYKGSLNSLIDMYQGKCDIVSLHLYDAETGQYNAPYVKRILTGEPFCLINVVL RKAGLYVQKGNPKNIQGWKDLKRADIRIINREKGSGARVLLDEQLGLLGVNPADVVGY GDIVTDHYAAASQVSSGQADAGIGAQHAAHMGSVDFIPLIDEQYDIVVLKKNEQLLKA VKEILNSEDYKANLSHLNGYETKLTGKVILET*" /label="yvgK CDS" gene complement(2928315..2929241) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /label="yvgK gene" downshifts complement(2928327) /Source="Nicolas_upshifts" /id="D1729" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="0.15268" /MaxDrop="6.72558" /score="21.9965704" /energy="-10.5" /TU="NA" /idTUdmin="U2617" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2929253..2929272) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2929274) /Source="Nicolas_upshifts" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2929288..2929291) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2929310..2929329 /Source="Nicolas_upshift_promotors" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2929319 /Source="Nicolas_upshifts" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="upshifts" CDS 2929352..2930134 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9302996; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molybdate-binding lipoprotein" /protein_id="NP_391218.1" /db_xref="EnsemblGenomes-Gn:BSU33380" /db_xref="EnsemblGenomes-Tr:CAB15343" /db_xref="GOA:O32208" /db_xref="InterPro:IPR005950" /db_xref="SubtiList:BG14094" /db_xref="UniProtKB/Swiss-Prot:O32208" /translation="MFKKYSIFIAALTAFLLVAGCSSNQSSTDSEKKVTLTISAAASA QDALEEIQKNYEKDHQHITIQDNYGSSGALQKQISQGAGADLFFSAAEDKFKKLVDDG DIAKKDSTELVGNEIVLVVPKNGDSPVTSFSNLAESEKIALGTPESVPAGAYGKESLT KLSLWDKVKDKIVYGKDVRQVLSYVETGNVDAGVVYKTDALVSKKVNIVDEAKADTHS PIVYPLGIVKDTKHRKEAKEFYEYLQSDEAMKVFEKYGFTAE*" /label="modA CDS" gene 2929352..2930134 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /label="modA gene" CDS 2930106..2930798 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="molybdenum transport permease" /protein_id="NP_391219.3" /db_xref="EnsemblGenomes-Gn:BSU33390" /db_xref="EnsemblGenomes-Tr:CAB15344" /db_xref="GOA:O32209" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011867" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14095" /db_xref="UniProtKB/Swiss-Prot:O32209" /translation="MRNMALLPSSISASEFFTPVVLSFQVAAVAGIVVIILGTLAGAW MSRASFFGKTALETCFMLPLVLPPTVVGFILIVIFGKHSFIGQAIEWIFQQPVIFTWW AAVIASAVVAFPLMYQSAKTGFADIDPDIQGAAMVDGASRWKVFIHISVPLAYPSLLT GSILSLARALGEFGATLMFAGNIPGVTQTLPTAIYVALDSGNNTLAWAWVVCIVVISF LMLFFIQQKKTH*" /label="modB CDS" gene 2930106..2930798 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /label="modB gene" downshifts 2930790 /Source="Nicolas_upshifts" /id="D1730" /incds=0 /nref=40 /ntot=195 /MaxReadThrough="0.43895" /MaxDrop="4.92503" /score="19.0609965" /energy="-9.4" /TU="NA" /idTUdmin="U2618" /TUdmin=9 /isTUend="TRUE" /label="downshifts" CDS complement(2930829..2931659) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /EC_number="1.1.1.283" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544192, 16232966, 17114254, 19585557" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544192, 16232966, 17114254, 19585557; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous glyoxal/methylglyoxal reductase" /protein_id="NP_391220.1" /db_xref="EnsemblGenomes-Gn:BSU33400" /db_xref="EnsemblGenomes-Tr:CAB15345" /db_xref="GOA:O32210" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3D3F" /db_xref="PDB:3F7J" /db_xref="SubtiList:BG14096" /db_xref="UniProtKB/Swiss-Prot:O32210" /translation="MPTSLKDTVKLHNGVEMPWFGLGVFKVENGNEATESVKAAIKNG YRSIDTAAIYKNEEGVGIGIKESGVAREELFITSKVWNEDQGYETTLAAFEKSLERLQ LDYLDLYLIHWPGKDKYKDTWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDAEIKPM VNQVEFHPRLTQKELRDYCKGQGIQLEAWSPLMQGQLLDNEVLTQIAEKHNKSVAQVI LRWDLQHGVVTIPKSIKEHRIIENADIFDFELSQEDMDKIDALNKDERVGPNPDELLF *" /label="pgoN CDS" gene complement(2930829..2931659) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /label="pgoN gene" downshifts complement(2930835) /Source="Nicolas_upshifts" /id="D1731" /incds=0 /nref=190 /ntot=269 /MaxReadThrough="4.7445" /MaxDrop="7.9269" /score="27.8070829" /energy="-9.7" /TU="U2620" /idTUdmin="U2620" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 2931522..2931526 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2931542..2931546 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2931551 /Source="Nicolas_upshifts" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2931661 /Source="Nicolas_upshifts" /id="D1732" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="0.95687" /MaxDrop="4.12116" /score="31.5807071" /energy="-11.6" /TU="NA" /idTUdmin="U2618" /TUdmin=880 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2931689..2931708) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2931707) /Source="Nicolas_upshifts" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2931723..2931730) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2931815..2931821 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2931835 /Source="Nicolas_upshifts" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2931836..2931854 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2931882..2932367 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 22307285, 25217289; Product type f: factor" /codon_start=1 /transl_table=11 /product="exported stress induced factor" /protein_id="NP_391221.1" /db_xref="EnsemblGenomes-Gn:BSU33410" /db_xref="EnsemblGenomes-Tr:CAB15346" /db_xref="SubtiList:BG14097" /db_xref="UniProtKB/Swiss-Prot:O32211" /translation="MKRIRIPMTLALGAALTIAPLSFASAEENPAPKMSQTTTAGTTA ADVGLNVNLDVLGIANQIADAIKSAQNRDGFVKNLMESSFYASGQKYNVMVFNLSQEY EDHLNGVQFYGSAVYDGITYGIWVFEDGTFTNKGDGGWINWAFRGWFDRDGSTVAFHR P*" /label="yvgO CDS" gene 2931882..2932367 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /label="yvgO gene" downshifts 2932366 /Source="Nicolas_upshifts" /id="D1733" /incds=0 /nref=18 /ntot=93 /MaxReadThrough="3.44281" /MaxDrop="6.83046" /score="31.5807071" /energy="-11.6" /TU="U2621" /idTUdmin="U2621" /TUdmin="-571" /isTUend="FALSE" /label="downshifts" CDS complement(2932411..2934423) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16021482, 16850406, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16021482, 16850406, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_391222.1" /db_xref="EnsemblGenomes-Gn:BSU33420" /db_xref="EnsemblGenomes-Tr:CAB15347" /db_xref="GOA:O32212" /db_xref="InterPro:IPR004705" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR018422" /db_xref="SubtiList:BG14098" /db_xref="UniProtKB/Swiss-Prot:O32212" /translation="MDIFLVVLVLLTIIAISNIVNRFIPFIPVPLIQVALGILAASFP QGLHFELNTELFFVLFIAPLLFNDGKRTPRAELWNLRAPILLLALGLVFATVIVGGYT IHWMIPAIPLAAAFGLAAILSPTDVVAVSALSGRVKMPKGILRLLEGEGLMNDASGLV AFKFAIAAAVTGAFSLAQAAVSFVFISLGGLLCGVVISFLIIRFRLFLRRLGMQDVTM HMLIQILTPFVIYLAAEEIGVSGILAVVAGGITHAVEQDRLESTMIKLQIVSSSTWNI ILFILNGLVFVILGTQIPDVISVIFNDTAISNMKVIGYILVITFTLMLLRFLWVLFFW NGKWFFNKDQNIYKPGLRSTLLISISGVRGAVTLAGSFSIPYFLEDGTPFPERNLILF LAAGVILCTLVIATVVLPILTEKEEEDEERNKKLLTARRKLIKTALQTIKEDMNETNK TASLAVIAEYNEKMKNLRFQQYTSSNRIKKHERKVRAQGVKAEQEALMKMLERGDIPE ETANVLQERFNELEILYANPFKVGLSKTRLKRLMYWIFFGEHKKPEMSILNEAGLIRA TRVKTAKAAIEYLEKHKTDEHKEVFLSVITFYKQLIFRLEHSHHELKSSAHFENQKLE VKLKAVQAIRNEIQTLFEEREISRDISHELRQYINDVEAAMLEGGE*" /label="nhaK CDS" gene complement(2932411..2934423) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /label="nhaK gene" downshifts complement(2932419) /Source="Nicolas_upshifts" /id="D1734" /incds=0 /nref=118 /ntot=238 /MaxReadThrough="2.66359" /MaxDrop="5.82216" /score="41.6492295" /energy="-13.2" /TU="NA" /idTUdmin="U2622" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(2934089..2934093) /Source="Nicolas_upshift_promotors" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2934091) /Source="Nicolas_upshifts" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2934424..2934575) /Source="Nicolas_S_feature" /locus_tag="new_3430344_3430495_c" /HighExp="dia5, T0.30H, T-0.40H, Salt, Diami, T1.0H, T0.0H, T1.30H, dia15, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.746, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1281" misc_feature complement(2934552..2934570) /Source="Nicolas_upshift_promotors" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2934575) /Source="Nicolas_upshifts" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2934678..2936393) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (hemoprotein beta-subunit)" /protein_id="NP_391223.1" /db_xref="EnsemblGenomes-Gn:BSU33430" /db_xref="EnsemblGenomes-Tr:CAB15348" /db_xref="GOA:O32213" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR011786" /db_xref="InterPro:IPR036136" /db_xref="SubtiList:BG14099" /db_xref="UniProtKB/Swiss-Prot:O32213" /translation="MVTKILKAPDGSPSDVERIKKESDYLRGTLKEVMLDRISAGIPD DDNRLMKHHGSYLQDDRDLRNERQKQKLEPAYQFMLRVRMPGGVSTPEQWLVMDDLSQ KYGNGTLKLTTRETFQMHGILKWNMKKTIQTIHSALLDTIAACGDVNRNVMCASNPYQ SEIHSEVYEWSKKLSDDLLPRTRAYHEIWLDEERVAGTPEEEVEPMYGPLYLPRKFKI GIAVPPSNDIDVFSQDLGFIAIVEDGKLIGFNVAIGGGMGMTHGDTATYPQLAKVIGF CRPEQMYDVAEKTITIQRDYGNRSVRKNARFKYTVDRLGLENVKEELENRLGWSLEEA KPYHFDHNGDRYGWVEGIEDKWHFTLFVEGGRITDYDDYKLMTGLREIAKVHTGEFRL TANQNLMIANVSSDKKEEISALIEQYGLTDGKHYSALRRSSMACVALPTCGLAMAEAE RYLPTLLDKIEEIIDENGLRDQEITIRMTGCPNGCARHALGEIGFIGKAPGKYNMYLG AAFDGSRLSKMYRENIGEADILSELRILLSRYAKEREEGEHFGDFVIRAGIIKATTDG TNFHD*" /label="cysI CDS" gene complement(2934678..2936393) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /label="cysI gene" downshifts complement(2934685) /Source="Nicolas_upshifts" /id="D1735" /incds=0 /nref=211 /ntot=254 /MaxReadThrough="3.28258" /MaxDrop="6.31358" /score="23.5256972" /energy="-13.8" /TU="U2624" /idTUdmin="U2624" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" CDS complement(2936419..2938236) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (flavoprotein alpha-subunit)" /protein_id="NP_391224.1" /db_xref="EnsemblGenomes-Gn:BSU33440" /db_xref="EnsemblGenomes-Tr:CAB15349" /db_xref="GOA:O32214" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010199" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14100" /db_xref="UniProtKB/Swiss-Prot:O32214" /translation="MQLQVMNSPFNQEQAELLNRLLPTLTESQKIWLSGYLSAQSVSA QEAAGTPAAAVSAEAPAPAVSKEVTVLYGSQTGNAQGLAENAGKQLEQSGFQVTVSSM SDFKPNQLKKVTNLLIVVSTHGEGEPPDNALSFHEFLHGRRAPKLEDLRFSVLALGDS SYEFFCQTGKEFDQRLEELGGKRISPRVDCDLDYDEPAAEWLEGVLKGLNEAGGGSAA PAPAAASQTGESSYSRTNPFRAEVLENLNLNGRGSNKETRHVELSLEGSGLTYEPGDS LGVYPENDPELVELLLKEMNWDPEEIVTLNKQGDVRPLKEALISHYEITVLTKPLLEQ AAQLTGNDELRELLAPGNEENVKAYIEGRDLLDLVRDYGPFSVSAQEFVSILRKMPAR LYSIASSLSANPDEVHLTIGAVRYDAHGRERKGVCSILCAERLQPGDTLPVYVQHNQN FKLPKDPETPIIMVGPGTGVAPFRSFMQEREETGAEGKAWMFFGDQHFVTDFLYQTEW QNWLKDGVLTKMDVAFSRDTEEKVYVQHRMLEHSAELFEWLQEGAAVYICGDEKHMAH DVHNTLLEIIEKEGNMSREEAEAYLADMQQQKRYQRDVY*" /label="cysJ CDS" gene complement(2936419..2938236) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /label="cysJ gene" promotor_-10 complement(2938278..2938297) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2938287..2938294 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2938297) /Source="Nicolas_upshifts" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="upshifts" upshifts 2938300 /Source="Nicolas_upshifts" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2938307..2938326 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2938310..2938317) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2938407..2940731) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544244, 24520113" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544244, 24520113; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription factor" /protein_id="NP_391225.1" /db_xref="EnsemblGenomes-Gn:BSU33450" /db_xref="EnsemblGenomes-Tr:CAB15350" /db_xref="GOA:O32215" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="SubtiList:BG14101" /db_xref="UniProtKB/Swiss-Prot:O32215" /translation="MNQQDKEWKEEQSRIDEVLKELEKKERFLETSAGGLKHDIIGLR KSFWEDVKVNFDDAHEAIETMASIKQQAELLSDREHNHRRMDQQLKRIHQLKKSPYFG RIDFIENGEEQAERIYIGLASCLDEKEEHFLIYDWRAPISSLYYNYSPGKAEYEVPGE TIEGEMVLKRQFMIKNGTLKAMFNTDMTIGDEMLQEVLSHHSDTQMKNIVSTIQKEQN QIIRNEKSKILIVQGAAGSGKTSAALQRVAYLLYRHRGVIDAGQIVLFSPNFLFNSYV SSVLPELGEENMEQATFQEYIEHRLGRKFKCESPFDQLEYCLTETKGGDFPTRLAGIT WKAGLSFQQFINEYVTRLSSEGMIFKNIIFRGQKLITKEQIQSYFYSLDQNHSIPNRM EQTAKWLLSELNKLEKKERRKDWVVHEAELLDKEDYLDVYKKLQERKRFSESTFNDYQ REQQLLAAIIVKKAFKPLKQAVRLLAFLDVTQLYLQLFSGWGGKFQHEKMDAIGELTR SAFTDNKLLYEDAAPFLYMQDLIEGRKKNTKIKHLFIDEAQDYSPFQMAYMRSIFPAA SMTVLGDINQSIYAHTINGDQRMDACFEDEPAEYVRLKRTYRSTRQIVEFTKAMLQDG ADIEPFNRSGEMPLVVKTEGHESLCQKLAQEIGRLKKKGHETIAVICKTAHQCIQAHA HMSEYTDVRLIHKENQPFQKGVCVIPVYLAKGIEFDAVLVYDASEEHYHTEHDRRLLY TACTRAMHMLAVFYTGEASPFVTAVPPHLYQIAE*" /label="helD CDS" gene complement(2938407..2940731) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /label="helD gene" downshifts complement(2938425) /Source="Nicolas_upshifts" /id="D1736" /incds=0 /nref=26 /ntot=168 /MaxReadThrough="1.20405" /MaxDrop="4.59044" /score="18.6044234" /energy="-8.5" /TU="NA" /idTUdmin="U2628" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2940751..2940758 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2940773..2940792 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(2940774..2940789) /Source="Nicolas_upshift_promotors" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2940777 /Source="Nicolas_upshifts" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2940779) /Source="Nicolas_upshifts" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2940824..2940843) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2940833) /Source="Nicolas_upshifts" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2940859..2940865) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2940869..2940888) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2940889) /Source="Nicolas_upshifts" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2940902..2940910) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2940916) /Source="Nicolas_upshifts" /id="D1737" /incds=0 /nref=19 /ntot=158 /MaxReadThrough="2.30604" /MaxDrop="4.26839" /score="16.6103553" /energy="-9.2" /TU="NA" /idTUdmin="U2630" /TUdmin=17 /isTUend="TRUE" /label="downshifts" CDS complement(2940929..2941537) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391226.1" /db_xref="EnsemblGenomes-Gn:BSU33460" /db_xref="EnsemblGenomes-Tr:CAB15351" /db_xref="GOA:O32216" /db_xref="InterPro:IPR005115" /db_xref="SubtiList:BG14102" /db_xref="UniProtKB/Swiss-Prot:O32216" /translation="MAWELLSVIGIIAFAVSGAIVAMEEEYDILGVYILGIVTAFGGG AIRNLLIGVPVSALWEQGAYFQIALLSITIVFLFPKLLLKHWNKWGNLSDAIGLAAFA IQGALYAVKMGHPLSAVIVAAVLTGSGGGIIRDLLAGRKPLVLKAEIYAVWAALGGLI VGLGWLGNSFGLYVLFFVLVVCRVCSYMFNWKLPNRSFRLDN*" /label="yvgT CDS" gene complement(2940929..2941537) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /label="yvgT gene" promotor_-10 complement(2941576..2941595) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2941593) /Source="Nicolas_upshifts" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2941611..2941615) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2941724..2942140) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391227.1" /db_xref="EnsemblGenomes-Gn:BSU33470" /db_xref="EnsemblGenomes-Tr:CAB15352" /db_xref="GOA:O32217" /db_xref="InterPro:IPR003752" /db_xref="InterPro:IPR012187" /db_xref="InterPro:IPR023380" /db_xref="SubtiList:BG14103" /db_xref="UniProtKB/Swiss-Prot:O32217" /translation="MKNRIVFLYASWVVALIAMLGSLYFSEIRKFIPCELCWYQRILM YPLVLILGIATFQGDTRVKKYVLPMAIIGAFISIMHYLEQKVPGFSGIKPCVSGVPCS GQYINWFGFITIPFLALIAFILIIIFMCLLKGEKSE*" /label="bdbC CDS" gene complement(2941724..2942140) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /label="bdbC gene" downshifts complement(2941734) /Source="Nicolas_upshifts" /id="D1738" /incds=0 /nref=120 /ntot=264 /MaxReadThrough="1.31968" /MaxDrop="6.21723" /score="26.5991603" /energy="-12.7" /TU="NA" /idTUdmin="U2631" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2942145..2942813) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11744713, 11872755, 12637552, 15661011, 17501922, 19535335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11744713, 11872755, 12637552, 15661011, 17501922, 19535335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391228.1" /db_xref="EnsemblGenomes-Gn:BSU33480" /db_xref="EnsemblGenomes-Tr:CAB15353" /db_xref="GOA:O32218" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:3EU3" /db_xref="PDB:3EU4" /db_xref="PDB:3GH9" /db_xref="PDB:3GHA" /db_xref="SubtiList:BG14104" /db_xref="UniProtKB/Swiss-Prot:O32218" /translation="MKKKQQSSAKFAVILTVVVVVLLAAIVIINNKTEQGNDAVSGQP SIKGQPVLGKDDAPVTVVEFGDYKCPSCKVFNSDIFPKIQKDFIDKGDVKFSFVNVMF HGKGSRLAALASEEVWKEDPDSFWDFHEKLFEKQPDTEQEWVTPGLLGDLAKSTTKIK PETLKENLDKETFASQVEKDSDLNQKMNIQATPTIYVNDKVIKNFADYDEIKETIEKE LKGK*" /label="bdbD CDS" gene complement(2942145..2942813) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /label="bdbD gene" promotor_-10 complement(2942865..2942884) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2942880) /Source="Nicolas_upshifts" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2942891) /Source="Nicolas_upshifts" /id="D1739" /incds=0 /nref=3 /ntot=9 /MaxReadThrough="7.34296" /MaxDrop="3.6233" /score="12.4442247" /energy="-11.3" /TU="U2632" /idTUdmin="U2633" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2942898..2942903) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2942933..2945041) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /EC_number="3.6.3.3" /EC_number="3.6.3.5" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Cd(II), Zn(II) and Co(II) exporter (ATPase)" /protein_id="NP_391229.3" /db_xref="EnsemblGenomes-Gn:BSU33490" /db_xref="EnsemblGenomes-Tr:CAB15354" /db_xref="GOA:O32219" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14105" /db_xref="UniProtKB/Swiss-Prot:O32219" /translation="MRLVKQEYVLDGLDCSNCARKIENGVKGIKGINGCAVNFAASTL TVSADGKEEQWVTNKVEKKVKSIDPHVTVRQKHIKKSADDGYRNRMVNMLIRMAAAVI LGAAAYLVQSGTIEFFLFLGAYLIIGGDIIIRAVKNIIRGQVFDEHFLMALATIGAFL IQQYPEGVAVMLFYQIGELFQGAAVSRSRKSISALMDIRPDYANLKTKNGIEQVSSED VQTGDIIVVNPGESIPLDGKVVQGSAMVDTSALTGESVPRKAAEGQDVMSGFINQNGV LHIEVTKGYQESAVSKILDLVQNASSRKARTENFITKFAKYYTPAVVIIAVLLAFVPP LVLSGAALSDWVYRALIFLVISCPCALVVSIPLGFFGGIGAASKAGVLVKGSNYLEAL NQVKYAVFDKTGTLTKGSFEVTEIKPAEGFTKDRLLEAAAYAELHSQHPIAESVRKAY GKMLSSDEIESYEEISGHGIFAKVNGTEILAGNKKLMEREQIEDVPDENAGTIVHVAV DQRYAGAIIIADEIKEDAAQAVADLKSLGIKQTAMLTGDSKQTGEAVGKQLGIGEVYA ELLPQDKVAQVEALEAKLLPSEKLIFVGDGINDTPVLARADIGVAMGGLGSDAAVEAA DIVLMTDQPSKIAEAIRIAKRTRRIVWQNIGFALGVKAIFLILGAFGIATMWEAVFSD VGVTLLAVANAMRVMRLKNK*" /label="cadA CDS" gene complement(2942933..2945041) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /label="cadA gene" S_feature complement(2945033..2945134) /Source="Nicolas_S_feature" /locus_tag="new_3440953_3441054_c" /HighExp="dia5, LBGtran, LBGstat, Diami, LBGexp, Gly, Lbtran, T0.30H, M40t45, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 0.999" /TUlongSig="SigB" /TUlongPSig="0.587" /label="S1282" promotor_-10 complement(2945128..2945147) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2945134) /Source="Nicolas_upshifts" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2945163..2945170) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2945201..2947609) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /EC_number="3.6.3.54" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper transporter ATPase" /protein_id="NP_391230.2" /db_xref="EnsemblGenomes-Gn:BSU33500" /db_xref="EnsemblGenomes-Tr:CAB15355" /db_xref="GOA:O32220" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="PDB:1JWW" /db_xref="PDB:1KQK" /db_xref="PDB:1OPZ" /db_xref="PDB:1OQ3" /db_xref="PDB:1OQ6" /db_xref="PDB:1P6T" /db_xref="PDB:2RML" /db_xref="PDB:2VOY" /db_xref="SubtiList:BG14106" /db_xref="UniProtKB/Swiss-Prot:O32220" /translation="MSEQKEIAMQVSGMTCAACAARIEKGLKRMPGVTDANVNLATET SNVIYDPAETGTAAIQEKIEKLGYHVVTEKAEFDIEGMTCAACANRIEKRLNKIEGVA NAPVNFALETVTVEYNPKEASVSDLKEAVDKLGYKLKLKGEQDSEAAAKKKEERKQTA RLIFSAVLSFPLLWAMVSHFTFTSFIWVPDIFLNPWMQFALATPVQFLIGWPFYVGAY KALRNKSANMDVLVALGTTAAYAYSLYLTFQSIGSHGHTDGLYYETSAILLTLILLGK LFETKAKGRSSDAIKKLMKLQAKTATVVRDGQEQIIPIDEVLVNDIVYVKPGERIPVD GEVVEGRSAVDESMITGESLPVDKNPGDSVTGSTVNANGFLKIKAVNVGKDTALSHII KIVEEAQGSKAPIQRLADQISGIFVPIVLGIAVLTFLIWYLWAAPGDFAEAISKFIAV LVIACPCALGLATPTSIMAGSGRAAEFGILFKGGEHLEKTHRLDTIVLDKTGTVTNGK PRLTDAIPFGRFEEKDLLQFAAAAETGSEHPLGEAIIAGVKDKGLEIPKLTRFEAKVG AGILAEAGGKSILVGTRKLMESEQVEHGALLAQMEELEAEGKTVMLVSIDGEAAGLVA VADTIKDTSRKAVARLKELGLDVIMMTGDNRRTAEAIAKEAGIANIIAEVLPEQKAAE IARLQKEGRQTAMVGDGINDAPALATADIGMAIGTGTDIAMETADITLIRGDLNSIAD AIRMSRLTMKNIKQNLFWALGYNSLGIPIAALGFLAPWIAGAAMAFSSVSVVLNALRL QKVK*" /label="copA CDS" gene complement(2945201..2947609) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /label="copA gene" downshifts complement(2945223) /Source="Nicolas_upshifts" /id="D1740" /incds=0 /nref=15 /ntot=68 /MaxReadThrough="5.02116" /MaxDrop="3.63756" /score="26.9828242" /energy="-7.9" /TU="U2633" /idTUdmin="U2635" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2945289) /Source="Nicolas_upshifts" /id="D1741" /incds=1 /nref=52 /ntot=227 /MaxReadThrough="5.93949" /MaxDrop="4.28993" /score="26.9828242" /energy="-7.9" /TU="U2633,U2635" /idTUdmin="U2635" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2947610..2947692) /Source="Nicolas_S_feature" /locus_tag="new_3443530_3443612_c" /HighExp="Diami, dia5, dia15, Gly, T0.30H, Heat, T1.0H, T1.30H, T0.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.999, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S1283" CDS complement(2947693..2947902) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344; Product type f: factor" /codon_start=1 /transl_table=11 /product="copper insertion chaperone and transporter component" /protein_id="NP_391231.1" /db_xref="EnsemblGenomes-Gn:BSU33510" /db_xref="EnsemblGenomes-Tr:CAB15356" /db_xref="GOA:O32221" /db_xref="InterPro:IPR000428" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR036163" /db_xref="PDB:1K0V" /db_xref="PDB:1P8G" /db_xref="PDB:2QIF" /db_xref="PDB:3I9Z" /db_xref="SubtiList:BG14107" /db_xref="UniProtKB/Swiss-Prot:O32221" /translation="MEQKTLQVEGMSCQHCVKAVETSVGELDGVSAVHVNLEAGKVDV SFDADKVSVKDIADAIEDQGYDVAK*" /label="copZ CDS" gene complement(2947693..2947902) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /label="copZ gene" promotor_-10 complement(2947926..2947945) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-10" upshifts complement(2947947) /Source="Nicolas_upshifts" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="upshifts" promotor_-35 complement(2947958..2947964) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-35" CDS complement(2947976..2948281) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17143269, 18048925, 22904286, 24831014, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17143269, 18048925, 22904286, 24831014, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of copper utilisation proteins-Cu(I)" /protein_id="NP_391232.1" /db_xref="EnsemblGenomes-Gn:BSU33520" /db_xref="EnsemblGenomes-Tr:CAB15357" /db_xref="GOA:O32222" /db_xref="InterPro:IPR003735" /db_xref="SubtiList:BG14108" /db_xref="UniProtKB/Swiss-Prot:O32222" /translation="MEKHNEHKTLNHKSSKEKDQITNRLKRIEGQVRGIQNMVENDRY CVDILVQISAVQAAMKNVALHLLEDHAHHCVADAIKSGDGEQAISELLDVFKKFTKS* " /label="csoR CDS" gene complement(2947976..2948281) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /label="csoR gene" misc_feature 2948245..2948264 /Source="Nicolas_upshift_promotors" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2948256 /Source="Nicolas_upshifts" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2948295..2948314) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-10" upshifts complement(2948321) /Source="Nicolas_upshifts" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="upshifts" promotor_-35 complement(2948328..2948334) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-35" promotor_-35 2948373..2948379 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2948394..2948412 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2948402 /Source="Nicolas_upshifts" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="upshifts" CDS 2948409..2949485 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /EC_number="1.1.1.371" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15937154, 20133360, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 20133360, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NADP(+)-dependent)" /protein_id="NP_391233.1" /db_xref="EnsemblGenomes-Gn:BSU33530" /db_xref="EnsemblGenomes-Tr:CAB15358" /db_xref="GOA:O32223" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="PDB:3GDO" /db_xref="PDB:3GFG" /db_xref="SubtiList:BG14057" /db_xref="UniProtKB/Swiss-Prot:O32223" /translation="MITLLKGRRKVDTIKVGILGYGLSGSVFHGPLLDVLDEYQISKI MTSRTEEVKRDFPDAEVVHELEEITNDPAIELVIVTTPSGLHYEHTMACIQAGKHVVM EKPMTATAEEGETLKRAADEKGVLLSVYHNRRWDNDFLTIKKLISEGSLEDINTYQVS YNRYRPEVQARWREKEGTATGTLYDLGSHIIDQTLHLFGMPKAVTANVMAQRENAETV DYFHLTLDYGKLQAILYGGSIVPANGPRYQIHGKDSSFIKYGIDGQEDALRAGRKPED DSWGADVPEFYGKLTTIRGSDKKTETIPSVNGSYLTYYRKIAESIREGAALPVTAEEG INVIRIIEAAMESSKEKRTIMLEH*" /label="iolW CDS" gene 2948409..2949485 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /label="iolW gene" downshifts 2949472 /Source="Nicolas_upshifts" /id="D1742" /incds=0 /nref=155 /ntot=248 /MaxReadThrough="2.17322" /MaxDrop="6.48885" /score="-5.36701412" /energy="-19.4" /TU="NA" /idTUdmin="U2636" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2949522..2950157) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17284825, 17725564, 18208493" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17284825, 17725564, 18208493; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:dichloroindophenol oxidoreductase (2-methylhydroquinone resistance)" /protein_id="NP_391234.1" /db_xref="EnsemblGenomes-Gn:BSU33540" /db_xref="EnsemblGenomes-Tr:CAB15359" /db_xref="GOA:O32224" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14058" /db_xref="UniProtKB/Swiss-Prot:O32224" /translation="MAKVLYITAHPHDEATSYSMATGKAFIESYKEANPNDEVVHIDL YKENIPHIDADVFSGWGKLQSGTGFEELSESEKAKVGRLGELSDQFASADKYVFVTPL WNFSFPPVMKAYLDSVAVAGKSFKYTEQGPVGLLTDKKAIHIQARGGYYSEGPAAEME MGHRYIGIMMNFFGVPSFDGIFVEGHNAEPDKAQQIKEDAIARAKEAGKTF*" /label="azoRB CDS" gene complement(2949522..2950157) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /label="azoRB gene" downshifts complement(2949535) /Source="Nicolas_upshifts" /id="D1743" /incds=0 /nref=211 /ntot=263 /MaxReadThrough="1.58189" /MaxDrop="6.89477" /score="31.0885268" /energy="-15.4" /TU="NA" /idTUdmin="U2637" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2950158..2950255) /Source="Nicolas_S_feature" /locus_tag="new_3446078_3446175_c" /HighExp="Heat, UNK1, G/S, Salt, HiTm, GM-0.1, MG 25, SMM, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1284" promotor_-10 complement(2950235..2950254) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2950255) /Source="Nicolas_upshifts" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2950268..2950274) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2950317..2952212) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12107147, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391235.1" /db_xref="EnsemblGenomes-Gn:BSU33550" /db_xref="EnsemblGenomes-Tr:CAB15360" /db_xref="GOA:O32225" /db_xref="SubtiList:BG14059" /db_xref="UniProtKB/Swiss-Prot:O32225" /translation="MNKTAANNQRIMPIVKDAFRIHANPFPWKKAIGSGFASGFPVLV GALAGHTDYGLIASIGGFVYLYAGGESYKKRALKLLLVSIGIALSFGLGTLLSGMLWM MAAVLGLIGAAAMFIFSALGIQGPAPMFFVLAFLVSSGLPADPSQALFRAGLTFLGGI FAMGIALIGWLWNKHGPEGAVLQKTYHQLAACLSAVGTPGFHNAQHQTVLMLRTARQT VLGKGNRRKKSRHDERFFRLLEKADDIFIAIIHFSAETPDRETAQIEKALRQTGDMLA NARVFNTFQINENESEPRRKLFEEINEVLYIASGRFDKQLDGEPSRLPSSFYFLRNAF DWKSPVLIRALKYGIVLFAADMFALAFGFARSYWIPLSAAAVMLGTTVVFTLHRAIQR SAGTVIGVILAGAILFFKPGGVYIAFCIAALQCLLEMLIVRNYALAVPFLTANALVIT ESMHGGAGAGYFMIARLTDVAVGSVIGLLGTMLLWRRFSTKRLPELVRNVIRLEGQFM EKLLTGQIADEHKLRVSLVRLRDAYDKALGEFPHANADALWPAISGAQHLGYYLLSAQ AHRRPSAPFSDEEINQLRAFFEQAEQSFIMKRMPADIQVPHVPHYPRISKELSALYSG LRTAFEK*" /label="yvaC CDS" gene complement(2950317..2952212) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /label="yvaC gene" promotor_-10 complement(2952263..2952274) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2952263) /Source="Nicolas_upshifts" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2952289..2952295) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2952362) /Source="Nicolas_upshifts" /id="D1744" /incds=0 /nref=20 /ntot=155 /MaxReadThrough="2.49984" /MaxDrop="4.21522" /score="11.4033831" /energy="-8" /TU="NA" /idTUdmin="U2639" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(2952375..2952776) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391236.1" /db_xref="EnsemblGenomes-Gn:BSU33560" /db_xref="EnsemblGenomes-Tr:CAB15361" /db_xref="GOA:O32226" /db_xref="InterPro:IPR020348" /db_xref="SubtiList:BG14060" /db_xref="UniProtKB/Swiss-Prot:O32226" /translation="MRYMKLFFLVTDIGFILYWLSAGFSLIPESWAFKHHDHPFMIAW NWSFFPLDILISVTGLYSLYLQRVNRADWKLMALISLVLTCCSGLQALSFWTFSSDFD LVWWLFNGYLLIYPLFFIHLLLKEGRRTKQS*" /label="yvaD CDS" gene complement(2952375..2952776) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /label="yvaD gene" CDS complement(2952773..2953132) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948170, 15849754, 16850406, 19549332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite-efflux transporter" /protein_id="NP_391237.1" /db_xref="EnsemblGenomes-Gn:BSU33570" /db_xref="EnsemblGenomes-Tr:CAB15362" /db_xref="GOA:O32227" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG14061" /db_xref="UniProtKB/Swiss-Prot:O32227" /translation="MNWVFLCLAILFEVAGTVSMKLSSGFTKLIPSLLLIFFYGGSLF FLTLTLKSIDVSVAYAVWSGMGIVLITVVGFLFFQEHVSVMKVISIGLIIAGVVSLNL IEHVAVSEPVHKSGQYK*" /label="yvaE CDS" gene complement(2952773..2953132) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /label="yvaE gene" CDS complement(2953129..2953701) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391238.1" /db_xref="EnsemblGenomes-Gn:BSU33580" /db_xref="EnsemblGenomes-Tr:CAB15363" /db_xref="GOA:O32228" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14062" /db_xref="UniProtKB/Swiss-Prot:O32228" /translation="MDKRILAETFRLIKQKGFSFTMNDLAAALGTSKRTLYAYYSSKD QLVEAVVEQFIAEMKQIERDIYENESLNVLEKVKQMLISLPQGMELLNMGLLNELKKY HYDAWLTLDAFIKEEWAIVLALLNECKQQKRIRNINPDLFVHMYIGSINQVYDPEYPL KHQFTTGEVLESIVDVLFNGITADEEADAT*" /label="yvaF CDS" gene complement(2953129..2953701) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /label="yvaF gene" promotor_-10 complement(2953739..2953758) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2953744) /Source="Nicolas_upshifts" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2953772..2953779) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2953812..2954606) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391239.1" /db_xref="EnsemblGenomes-Gn:BSU33590" /db_xref="EnsemblGenomes-Tr:CAB15364" /db_xref="GOA:O32229" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14063" /db_xref="UniProtKB/Swiss-Prot:O32229" /translation="MKLNLQGKTALVTGSTSGIGKAIASSLAEEGAAVIINGRREEKV NQTIDELKTQHAEAVLYPAAFDLGTEEGCNELFQAYPEVDILVNNLGIFEPAEYFDIP DDEWFRFFEVNIMSGVRLTRRYLHNMIEKKEGRVIFIASEAAIMPSQEMAHYSATKTM QLSISRSLAELATGTNVTVNTVMPGSTLTEGVETMLNSLYPGENLTVQEAEARFMKEN RPTSIIQRLIRPEEIAHFVTFLSSPLSSAINGAALRADGGLVRSVF*" /label="yvaG CDS" gene complement(2953812..2954606) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /label="yvaG gene" promotor_-10 complement(2954627..2954645) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2954639) /Source="Nicolas_upshifts" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2954660..2954666) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2954672..2954691) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2954683) /Source="Nicolas_upshifts" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2954685..2954750) /Source="Nicolas_S_feature" /locus_tag="new_3450605_3450670_c" /HighExp="H2O2, Heat, Diami, G180, Paraq, dia15, Oxctl, BMM, G135, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.47, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="0.996, 1" /label="S1285" promotor_-35 complement(2954705..2954712) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2954792..2955151) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /product="transfer-messenger RNA (tmRNA, 10Sa RNA)" /experiment="publication(s) with functional evidences, PMID:11395451, 11918677, 14766921, 17369301, 18673456" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11918677, 14766921, 17369301, 18673456" /label="ssrA RNA" gene complement(2954792..2955151) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /label="ssrA gene" downshifts complement(2954795) /Source="Nicolas_upshifts" /id="D1745" /incds=0 /nref=260 /ntot=272 /MaxReadThrough="4.32959" /MaxDrop="9.81359" /score="26.7868133" /energy="-15.8" /TU="U2642,U2644" /idTUdmin="U2643" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2955135..2955143) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2955145) /Source="Nicolas_upshifts" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2955158..2955163) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2955203..2955222) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2955211) /Source="Nicolas_upshifts" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2955213..2955277) /Source="Nicolas_S_feature" /locus_tag="new_3451133_3451197_c" /HighExp="Etha, C90, dia5, dia15, Diami, T0.0H, T-0.40H, T-1.40H, LPhT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.997, 0.996, 1" /TUlongSig="SigB, SigA" /TUlongPSig="0.999, 0.753" /label="S1286" promotor_-35 complement(2955235..2955239) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2955277) /Source="Nicolas_upshifts" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="upshifts" promotor_-10 complement(2955278..2955297) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-10" promotor_-35 complement(2955312..2955319) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-35" CDS complement(2955328..2955798) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10947848, 11395451, 11918677, 12682299, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10947848, 11395451, 11918677, 12682299, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="tmRNA-binding protein" /protein_id="NP_391240.1" /db_xref="EnsemblGenomes-Gn:BSU33600" /db_xref="EnsemblGenomes-Tr:CAB15365" /db_xref="GOA:O32230" /db_xref="InterPro:IPR000037" /db_xref="InterPro:IPR020081" /db_xref="InterPro:IPR023620" /db_xref="SubtiList:BG14064" /db_xref="UniProtKB/Swiss-Prot:O32230" /translation="MPKGSGKVLSQNKKANHDYFIEETYETGIVLQGTEIKSIRAGRV NLKDSFAKIERGEVFLHNMHVSPYEQGNRYNHDPLRTRKLLMHRKEINKLIGLTKEKG YSLVPLKLYLKNGFAKVLLGLGKGKKNYDKREDLKRKDAKREIERAFRDSQKGF*" /label="smpB CDS" gene complement(2955328..2955798) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /label="smpB gene" promotor_no_box 2955625..2955725 /Source="Nicolas_upshift_promotors" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2955685 /Source="Nicolas_upshifts" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2955795 /Source="Nicolas_upshifts" /id="D1746" /incds=0 /nref=2 /ntot=105 /MaxReadThrough="0.62459" /MaxDrop="3.18501" /score="-9.3042809" /energy="-3.3" /TU="NA" /idTUdmin="U2647" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2955843..2955862) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(2955849) /Source="Nicolas_upshifts" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="upshifts" S_feature complement(2955851..2955942) /Source="Nicolas_S_feature" /locus_tag="new_3451771_3451862_c" /HighExp="Etha, S8, Cold, S7, G135, G180, G150, H2O2, M9-stat, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig="0.753" /label="S1287" promotor_-35 complement(2955878..2955881) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" CDS complement(2955943..2958282) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /EC_number="3.1.13.1" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 19215769, 22333191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 19215769, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease R" /protein_id="NP_391241.1" /db_xref="EnsemblGenomes-Gn:BSU33610" /db_xref="EnsemblGenomes-Tr:CAB15366" /db_xref="GOA:O32231" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004476" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR011805" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013223" /db_xref="InterPro:IPR022966" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14065" /db_xref="UniProtKB/Swiss-Prot:O32231" /translation="MEKEAFMEKLLSFMKEEAYKPLTVQELEEMLNITEAEEFKELVK ALVALEEKGLIVRTRSDRYGIPEKMNLIKGKISAHAKGFAFLLPEDTSLSDVFIPPNE LNTAMNGDIVMVRLNSQSSGSRQEGTVIRILERAIQRVVGTYTETRNFGFVIPDDKKI TSDIFIPKNGKNGAAEGHKVVVKLTSYPEGRMNAEGEVETILGHKNDPGIDILSVIHK HGLPGEFPADAMEQASSTPDTIDEKDLKDRRDLRDQVIVTIDGADAKDLDDAVTVTKL DDGSYKLGVHIADVSHYVTENSPIDKEALERGTSVYLVDRVIPMIPHRLSNGICSLNP KVDRLTLSCEMTINSQGQVTEHEIFQSVIKTTERMTYSDVNKILVDDDEELKQKYEPL VPMFKDMERLAQILRDKRMDRGAVDFDFKEAKVLVDDEGAVKDVVIRERSVAEKLIEE FMLVANETVAEHFHWMNVPFIYRIHEEPNAEKLQKFLEFVTTFGYVVKGTAGNIHPRA LQSILDAVRDRPEETVISTVMLRSMKQAKYDPQSLGHFGLSTEFYTHFTSPIRRYPDL IVHRLIRTYLINGKVDEATQEKWAERLPDIAEHTSSMERRAVDAERETDDLKKAEYML DKIGEEFDGMISSVTNFGMFVELPNTIEGLVHVSFMTDDYYRFDEQHFAMIGERTGNV FRIGDEITVKVVDVNKDERNIDFEIVGMKGTPRRPRELDSSRSRKRGKPARKRVQSTN TPVSPAPSEEKGEWFTKPKKKKKKRGFQNAPKQKRKKKK*" /label="rnr CDS" gene complement(2955943..2958282) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /label="rnr gene" promotor_-35 2957043..2957046 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2957062..2957065 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2957071 /Source="Nicolas_upshifts" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2958301..2959041) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1369099, 17369301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase" /protein_id="NP_391242.2" /db_xref="EnsemblGenomes-Gn:BSU33620" /db_xref="EnsemblGenomes-Tr:CAB15367" /db_xref="GOA:O32232" /db_xref="InterPro:IPR012354" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14066" /db_xref="UniProtKB/Swiss-Prot:O32232" /translation="MKVVTPKPFTFKGGDKAVLLLHGFTGNTADVRMLGRYLNERGYT CHAPQYEGHGVPPEELVHTGPEDWWKNVMDGYEYLKSEGYESIAACGLSLGGVFSLKL GYTVPIKGIVPMCAPMHIKSEEVMYQGVLSYARNYKKFEGKSPEQIEEEMKEFEKTPM NTLKALQDLIADVRNNVDMIYSPTFVVQARHDHMINTESANIIYNEVETDDKQLKWYE ESGHVITLDKERDLVHQDVYEFLEKLDW*" /label="estA CDS" gene complement(2958301..2959041) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /label="estA gene" promotor_-10 complement(2958697..2958715) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-10" upshifts complement(2958709) /Source="Nicolas_upshifts" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="upshifts" promotor_-35 complement(2958730..2958736) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-35" misc_feature complement(2959069..2959087) /Source="Nicolas_upshift_promotors" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2959083) /Source="Nicolas_upshifts" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="upshifts" downshifts complement(2959171) /Source="Nicolas_upshifts" /id="D1747" /incds=0 /nref=30 /ntot=212 /MaxReadThrough="6.16751" /MaxDrop="5.2246" /score="-4.14736839" /energy="-9.1" /TU="U2650" /idTUdmin="U2649" /TUdmin="-3234" /isTUend="FALSE" /label="downshifts" CDS complement(2959173..2959403) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10074070, 10644701, 16243836" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074070, 10644701, 16243836; Product type f: factor" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_391243.1" /db_xref="EnsemblGenomes-Gn:BSU33630" /db_xref="EnsemblGenomes-Tr:CAB15368" /db_xref="GOA:O32233" /db_xref="InterPro:IPR004692" /db_xref="SubtiList:BG14067" /db_xref="UniProtKB/Swiss-Prot:O32233" /translation="MHAVLITLLVIVSIALIIVVLLQSSKSAGLSGAISGGAEQLFGK QKARGLDLILHRITVVLAVLFFVLTIALAYIL*" /label="secG CDS" gene complement(2959173..2959403) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /label="secG gene" promotor_-10 complement(2959433..2959452) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(2959454) /Source="Nicolas_upshifts" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="upshifts" promotor_-35 complement(2959467..2959470) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" promotor_-35 2959492..2959498 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2959512..2959523 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2959513 /Source="Nicolas_upshifts" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="upshifts" CDS 2959552..2960322 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391244.1" /db_xref="EnsemblGenomes-Gn:BSU33640" /db_xref="EnsemblGenomes-Tr:CAB15369" /db_xref="GOA:O32234" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14068" /db_xref="UniProtKB/Swiss-Prot:O32234" /translation="MPLISIDSRKHLFYEEYGQGIPIIFIHPPGMGRKVFYYQRLLSK HFRVIFPDLSGHGDSDHIDQPASISYYANEIAQFMDALHIDKAVLFGYSAGGLIAQHI GFTRPDKVSHLILSGAYPAVHNVIGQKLHKLGMYLLEKNPGLLMKILAGSHTKDRQLR SILTDHMKKADQAHWHQYYLDSLGYNCIEQLPRLEMPMLFMYGGLRDWTFTNAGYYRR SCRHAEFFRLEYQGHQLPTKQWKTCNELVTGFVLTHHS*" /label="yvaM CDS" gene 2959552..2960322 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /label="yvaM gene" promotor_-35 2959574..2959582 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2959593..2959611 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2959623 /Source="Nicolas_upshifts" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2960362..2960595) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional regulator" /protein_id="NP_391245.1" /db_xref="EnsemblGenomes-Gn:BSU33650" /db_xref="EnsemblGenomes-Tr:CAB15370" /db_xref="GOA:O32235" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG14159" /db_xref="UniProtKB/Swiss-Prot:O32235" /translation="MPVEKIQIRRDYVLQYMVNNDYSLNQLALEIGVSPATLSRVLNG ERRPGQLVIGKMLHYFNLKFEDLFYYDFVDKSQ*" /label="yvzC CDS" gene complement(2960362..2960595) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /label="yvzC gene" promotor_-35 2960686..2960693 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-35" upshifts 2960701 /Source="Nicolas_upshifts" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="upshifts" promotor_-10 2960705..2960724 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-10" CDS 2960747..2961154 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_391246.1" /db_xref="EnsemblGenomes-Gn:BSU33660" /db_xref="EnsemblGenomes-Tr:CAB15371" /db_xref="GOA:O32236" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14069" /db_xref="UniProtKB/Swiss-Prot:O32236" /translation="MESFGEQLRALREERKLTVNQLATYSGVSAAGISRIENGKRGVP KPATIKKLAEALKIPYEGLMYKAGYIEEVHEARAPYETKCKLLEKAEAYDLKNLALLE NEKWQYLNKEDLLMLDHYFSFISDEAKKRSADD*" /label="rghRA CDS" gene 2960747..2961154 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /label="rghRA gene" CDS 2961184..2961603 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional repressor" /protein_id="NP_391247.1" /db_xref="EnsemblGenomes-Gn:BSU33670" /db_xref="EnsemblGenomes-Tr:CAB15372" /db_xref="GOA:O32237" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14070" /db_xref="UniProtKB/Swiss-Prot:O32237" /translation="MSPFGQQLRELRRARKLTVNQLAVYSGISSATISKIENGKRGTP KPATIKKLAAVLKVPYENLMAAAGHIQAFPEEIREASEGYQSVYEIYQTAVTRGAEHL PIFNSQKWEHLSKQDIENLSKYFDFLSSEAKKRASSS*" /label="rghRB CDS" gene 2961184..2961603 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /label="rghRB gene" promotor_-35 2961641..2961648 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2961662..2961681 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2961669 /Source="Nicolas_upshifts" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="upshifts" CDS 2961695..2962021 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20639328; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catechol dioxygenase" /protein_id="NP_391248.2" /db_xref="EnsemblGenomes-Gn:BSU33680" /db_xref="EnsemblGenomes-Tr:CAB15373" /db_xref="GOA:O32238" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14071" /db_xref="UniProtKB/Swiss-Prot:O32238" /translation="MNQSEMCPRFEKAVDILSKRWVALIVFQLLNGSQRFSEIEAALP NLSGRVLSERLKELELEGVVKRDVIPETPVRIEYSLTDKGKALAPILGEISKWATEWI DPSFLD*" /label="catR CDS" gene 2961695..2962021 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /label="catR gene" S_feature 2962022..2962106 /Source="Nicolas_S_feature" /locus_tag="new_3457942_3458026" /HighExp="Cold, H2O2, Diami, LBGstat, LPhT, dia15, G180, Paraq, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.985" /label="S1288" promotor_-35 2962077..2962084 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2962097..2962115 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2962108 /Source="Nicolas_upshifts" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="upshifts" CDS 2962146..2963846 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8188684, 11872722, 27899502; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative methyl-accepting transducer" /protein_id="NP_391249.1" /db_xref="EnsemblGenomes-Gn:BSU33690" /db_xref="EnsemblGenomes-Tr:CAB15374" /db_xref="GOA:O32239" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR024478" /db_xref="InterPro:IPR035440" /db_xref="SubtiList:BG14072" /db_xref="UniProtKB/Swiss-Prot:O32239" /translation="MRLTISRKFSLVFLTLILINLLVGGIGVLNMQHIIQKTDEINTK WIDGIKGITSINYVTEHLSSKEKDFLIYTDKSKMDTLDQEMNQIMEDINQKLDNYEKT ISTDKEQKLFEQLQTKVNTYMDIHAQIIESGRTNDMDKARGLLVQTEASFEDMKKTIT QLVDLNQEGSNTAVKETKAVYHKGLIYTALLVAASILISIFIWLYITRNIVKPIIRMK ESANHIAEGDLSNDMEALNSKDELGDLNEALQKMVGNLRDIVGYSKDISSRVLSSSQV LATATNETRSGSKHITETMNEMAEGSEQQAQDAVTIAESMNEFTESIDKAYNHGITIS DTSQNVLELAVSGNENMATSLQQMKTIHHIVEEAVHKVRSLEQHSQDINKLVQVINGI AEQTNLLSLNAAIEAARAGESGKGFAVVAEEVRKLADGVSDSVQDITRIVNGTQQEIH TVITYLESSFTEVEKGTENLTDTGQAMQHIKQSVTHVADSIKEVTDGLKQLTNQSITI NQSIENIASVSEESAAGIEETFSITEQSAHSMDQVLLNAEELEQLANELNEKMGQFTI *" /label="yvaQ CDS" gene 2962146..2963846 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /label="yvaQ gene" S_feature complement(2962862..2963855) /Source="Nicolas_S_feature" /locus_tag="new_3458782_3459775_c" /HighExp="S6, S5, S7, C30, S8, S4, S3, LoTm, BT, B36" /AntisenseName="yvaQ" /AntisenseCor="-0.38660715434937498" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1289" downshifts 2963824 /Source="Nicolas_upshifts" /id="D1748" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="1.43789" /MaxDrop="3.86744" /score="26.1532813" /energy="-12.2" /TU="NA" /idTUdmin="U2655" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2963886..2964566) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391250.1" /db_xref="EnsemblGenomes-Gn:BSU33700" /db_xref="EnsemblGenomes-Tr:CAB15375" /db_xref="GOA:P39775" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12636" /db_xref="UniProtKB/Swiss-Prot:P39775" /translation="MNVLEQLMTYYAQNGSYVMDEFGRHFLMSAYGVLFAAVVGVPAG ILIAHFRRLSAWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDMIVRGSNATNGTAIILAGAIPTAVMAVGADLLMAWLERALSPVKKKRTG AKHVQSAA*" /label="opuBD CDS" gene complement(2963886..2964566) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /label="opuBD gene" downshifts complement(2963900) /Source="Nicolas_upshifts" /id="D1749" /incds=0 /nref=119 /ntot=171 /MaxReadThrough="3.12805" /MaxDrop="5.39624" /score="35.0134287" /energy="-12.2" /TU="NA" /idTUdmin="U2657" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2964260..2964266 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2964281..2964299 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2964286..2967037 /Source="Nicolas_S_feature" /locus_tag="new_3460206_3462957" /HighExp="Sw, M9-stat, B60, Salt, LoTm, T0.30H, BC, Gly, B36, T1.0H" /AntisenseName="opuBC" /AntisenseCor="-0.13125567572652899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1290" upshifts 2964286 /Source="Nicolas_upshifts" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2964583..2965503) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (choline-binding lipoprotein)" /protein_id="NP_391251.1" /db_xref="EnsemblGenomes-Gn:BSU33710" /db_xref="EnsemblGenomes-Tr:CAB15376" /db_xref="GOA:Q45462" /db_xref="InterPro:IPR007210" /db_xref="PDB:3R6U" /db_xref="SubtiList:BG12635" /db_xref="UniProtKB/Swiss-Prot:Q45462" /translation="MKRKYLKLMIGLALAATLTLSGCSLPGLSAAADQTIKIGAQSMS ESEIIASMLGQLIEHHTDLKTTTIKNLGSNAVQQQALMNGEIDIAATRYTGDALTGTL RMEPEKDPDKALALTQREFKKRYDLKWYDSYGFDNTYAFTVSKELADQYHLETVSDVK KWAPQLKLGVDNYWMKLKGNGYQDFTKTYGMTFGGTYPMQIGLVYDAVKSGKMDIVLA YSTDGRIKSYGLKMLKDDKQFFPPYDCSPVVPEKVLKEHPELEGIIKKMLGKIDTATM QELNYEVDGNLKEPSVVAKEYLEKHRYFES*" /label="opuBC CDS" gene complement(2964583..2965503) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /label="opuBC gene" CDS complement(2965515..2966168) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391252.1" /db_xref="EnsemblGenomes-Gn:BSU33720" /db_xref="EnsemblGenomes-Tr:CAB15377" /db_xref="GOA:Q45461" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12634" /db_xref="UniProtKB/Swiss-Prot:Q45461" /translation="MHHIVQFLQTNGGELLYKTYEHITISLIAVILGVLVAVPLGVVL TRMKKGAGTIIGIVNIIQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIRGVNKNLLESGKGIGMTPAEQVRLVELPLAAPVIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIVIDYVLAVAERKLTPAGMQRLKELS* " /label="opuBB CDS" gene complement(2965515..2966168) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /label="opuBB gene" CDS complement(2966185..2967330) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 18321243, 21658392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 18321243, 21658392; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (ATP-binding protein)" /protein_id="NP_391253.1" /db_xref="EnsemblGenomes-Gn:BSU33730" /db_xref="EnsemblGenomes-Tr:CAB15378" /db_xref="GOA:Q45460" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12633" /db_xref="UniProtKB/Swiss-Prot:Q45460" /translation="MLTLENVSKTYKGGKKAVNNVNLKIAKGEFICFIGPSGCGKTTT MKMINRLIEPSAGKIFIDGENIMDQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEQQRKERARELLKLVDMGPEYVDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQKTLHKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDDILRNPADEFVEEFIGKERLIQSSSPDVERVDQIMNTQPVTITADKTLSEAIQLM RQERVDSLLVVNDERVLQGYVDVEIIDQCRKKANLVSEVLHEDIYTVLGGTLLRDTVR KILKRGVKYVPVVDEDRRLIGIVTRASLVDIVYDSLWGEEKQLAALS*" /label="opuBA CDS" gene complement(2966185..2967330) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /label="opuBA gene" S_feature complement(2967331..2967398) /Source="Nicolas_S_feature" /locus_tag="new_3463251_3463318_c" /HighExp="T5.0H, T3.30H, T3.0H, T-5.40H, T4.0H, T-0.40H, T-1.40H, T2.30H, T-3.40H, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1291" upshifts complement(2967398) /Source="Nicolas_upshifts" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2967399..2967418) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2967429..2967433 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2967433..2967436) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2967449..2967467 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2967454 /Source="Nicolas_upshifts" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2967549..2967553 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2967569..2967588 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2967572 /Source="Nicolas_upshifts" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="upshifts" CDS 2967614..2968147 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (controlling choline uptake)" /protein_id="NP_391254.2" /db_xref="EnsemblGenomes-Gn:BSU33740" /db_xref="EnsemblGenomes-Tr:CAB15379" /db_xref="GOA:C0SPB8" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14073" /db_xref="UniProtKB/Swiss-Prot:C0SPB8" /translation="MEKDPLTIIEQAEDHFIERIAENMHAFGMPSTVGRVLGIIYMNR KPMTLTELSEATGMSKTRMSQVVREMLDANIAEKVFEKGVRKDLYEVEQDYYQTFITL FSATWSKVVSKNKMMHKKLNRELLSVLDEELTPEAEEKVNELLKELKEWLDYYNWLSR LIEFFESEDIFKYVPKP*" /label="yvaV CDS" gene 2967614..2968147 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /label="yvaV gene" S_feature complement(2967814..>2968213) /Source="Nicolas_S_feature" /locus_tag="new_3463734_3464253_c" /HighExp="S8, Cold, C30, GM 25, GM 60, BC, T-4.40H, M/G, GM-0.1, MG 120" /AntisenseName="yvaV" /AntisenseCor="-7.6123637680436104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.503, 1, 0.758" /TUlongSig="NA" /TUlongPSig="NA" /label="S1292" downshifts 2968136 /Source="Nicolas_upshifts" /id="D1750" /incds=0 /nref=51 /ntot=161 /MaxReadThrough="2.68472" /MaxDrop="4.69377" /score="-3.5823381" /energy="-8.6" /TU="NA" /idTUdmin="U2659" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(2968213,2968220) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs14" N_region 2968214..2968219 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs14" S_feature <2968220..2968295 /Source="Nicolas_S_feature" /locus_tag="new_3466412_3467550" /HighExp="Pyr, S8, nit, C30, GM 150, M9-stat, S7, S2, G/S, S1" /AntisenseName="sdpI" /AntisenseCor="-7.9710115369408502E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.636, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1297" S_feature complement(<2968220..2968286) /Source="Nicolas_S_feature" /locus_tag="new_3467393_3467541_c" /HighExp="Salt, B36, Gly, B60, LoTm, S8, GM 5, MG 25, Cold, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1298" CDS complement(2968291..2968980) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391260.1" /db_xref="EnsemblGenomes-Gn:BSU33800" /db_xref="EnsemblGenomes-Tr:CAB15385" /db_xref="GOA:O34742" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12640" /db_xref="UniProtKB/Swiss-Prot:O34742" /translation="MEVLQQLGTYYSQNGGYVLQEFYRHFLMSVYGVLFAAIVGIPLG ILIARYRRLSGWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDIIVRGSNATNGTAIILAGAIPTALMAVIADLVMGWLERALSPIKKKKGN FIIADRKTTSI*" /label="opuCD CDS" gene complement(2968291..2968980) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /label="opuCD gene" downshifts complement(2968331) /Source="Nicolas_upshifts" /id="D1757" /incds=0 /nref=95 /ntot=199 /MaxReadThrough="5.55394" /MaxDrop="6.7177" /score="8.72167152" /energy="-11.6" /TU="U2667" /idTUdmin="U2667" /TUdmin="-1166" /isTUend="FALSE" /label="downshifts" promotor_-35 2968923..2968931 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2968945..2968964 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2968959 /Source="Nicolas_upshifts" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2968998..2969909) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 28256787; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (osmoprotectant-binding lipoprotein)" /protein_id="NP_391261.1" /db_xref="EnsemblGenomes-Gn:BSU33810" /db_xref="EnsemblGenomes-Tr:CAB15386" /db_xref="GOA:O32243" /db_xref="InterPro:IPR007210" /db_xref="PDB:3PPN" /db_xref="PDB:3PPO" /db_xref="PDB:3PPP" /db_xref="PDB:3PPQ" /db_xref="PDB:3PPR" /db_xref="SubtiList:BG12639" /db_xref="UniProtKB/Swiss-Prot:O32243" /translation="MTKIKWLGAFALVFVMLLGGCSLPGLGGASDDTIKIGAQSMTES EIVANMIAQLIEHDTDLNTALVKNLGSNYVQHQAMLGGDIDISATRYSGTDLTSTLGK EAEKDPKKALNIVQNEFQKRFSYKWFDSYGFDNTYAFTVTKKFAEKEHINTVSDLKKN ASQYKLGVDNAWLKRKGDGYKGFVSTYGFEFGTTYPMQIGLVYDAVKNGKMDAVLAYS TDGRIKAYDLKILKDDKRFFPPYDCSPVIPEKVLKEHPELEGVINKLIGQIDTETMQE LNYEVDGKLKEPSVVAKEFLEKHHYFD*" /label="opuCC CDS" gene complement(2968998..2969909) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /label="opuCC gene" CDS complement(2969929..2970582) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391262.1" /db_xref="EnsemblGenomes-Gn:BSU33820" /db_xref="EnsemblGenomes-Tr:CAB15387" /db_xref="GOA:O34878" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12638" /db_xref="UniProtKB/Swiss-Prot:O34878" /translation="MNQMMTFLQTNGGELLYKTGEHLYISLIAVVLGIIVAVPLGVAL TRMKKGAGAVIGFVNIVQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIKGVNKNLLESGKGIGMTGWEQIRLVEIPLAIPIIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIIIDYVLAVTERKVTPKGLQGMKEVS* " /label="opuCB CDS" gene complement(2969929..2970582) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /label="opuCB gene" CDS complement(2970605..2971747) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10216873, 9925583, 21658392, 27378384, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216873, 9925583, 21658392, 27378384, 27683249; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (ATP-binding protein)" /protein_id="NP_391263.1" /db_xref="EnsemblGenomes-Gn:BSU33830" /db_xref="EnsemblGenomes-Tr:CAB15388" /db_xref="GOA:O34992" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12637" /db_xref="UniProtKB/Swiss-Prot:O34992" /translation="MLKLEQVSKVYKGGKKAVNSIDLDIAKGEFICFIGPSGCGKTTT MKMINRLIEPSSGRIFIDGENIMEQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEEKRKERARELLKLVDMGPEYLDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQRTLNKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDEILRNPANEFVEEFIGKERLIQSRPDIERVEQMMNRTPVTVSADKTLSQAIQLMR EKRVDSLLVVDRQNVLKGYVDVEMIDQNRKKASIVGDVYRSDIYTVQKGALLRDTVRK ILKQGIKYVPVVDEQNHLAGIVTRASLVDIVYDSIWGDEENQLMTI*" /label="opuCA CDS" gene complement(2970605..2971747) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /label="opuCA gene" promotor_-10 complement(2971791..2971810) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-10" upshifts complement(2971806) /Source="Nicolas_upshifts" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="upshifts" promotor_-35 complement(2971825..2971828) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-35" promotor_-35 2971944..2971951 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2971964..2971983 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2971975 /Source="Nicolas_upshifts" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="upshifts" CDS 2972011..2972568 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23960087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23960087; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative transcriptional regulator of choline uptake systems" /protein_id="NP_391264.1" /db_xref="EnsemblGenomes-Gn:BSU33840" /db_xref="EnsemblGenomes-Tr:CAB15389" /db_xref="GOA:O34709" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14079" /db_xref="UniProtKB/Swiss-Prot:O34709" /translation="MKKTALDIIEHAEEHLIEKIAENMHTFGMPSTVGRVLGIIYMNR KPMTLSELSEATGMSKTRMSQVVREMIDANIAEKVFEKGVRKDLYDVEQDYYQTFISL FAANWTKVVSKNKVLYKKLNRELSDLLQRDGLTPEAEEKVNQLLNELKEWLHYYDWLS RLIEFFESEEVFRYVPKTKECSSLK*" /label="opcR CDS" gene 2972011..2972568 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /label="opcR gene" S_feature 2972569..2973333 /Source="Nicolas_S_feature" /locus_tag="new_3471824_3472588" /HighExp="HiOs, GM 5, GM 10, Salt, MG 15, MG 10, MG 25, T0.0H, T-2.40H, GM 45" /AntisenseName="yvbG" /AntisenseCor="-0.14921239095219299" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1299" CDS complement(2972586..2973221) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391265.1" /db_xref="EnsemblGenomes-Gn:BSU33850" /db_xref="EnsemblGenomes-Tr:CAB15390" /db_xref="GOA:O32244" /db_xref="InterPro:IPR002771" /db_xref="SubtiList:BG14080" /db_xref="UniProtKB/Swiss-Prot:O32244" /translation="MMFSFIVHVFISLFAVSNPIGNVPIFLTLTEGYTAAERKAIARK AAILSFFILAAFLVFGHLIFKLFDINIHALRVAGGIFIFGIAYNLLNAKESHVQSLHH DEHKESKEKADISVTPLSIPIIAGPGTIATVMSLSAGHSGIGHYAAVMIGIAAVIALT FLFFHYSAFISSKLGKTEMNVITRLMGLILAVVAVGMIGAGLKGMFPVLTS*" /label="yvbG CDS" gene complement(2972586..2973221) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /label="yvbG gene" downshifts complement(2972599) /Source="Nicolas_upshifts" /id="D1758" /incds=0 /nref=21 /ntot=50 /MaxReadThrough="2.02169" /MaxDrop="4.45088" /score="10.9231366" /energy="-16.4" /TU="NA" /idTUdmin="U2669" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2973262..2973280) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2973268) /Source="Nicolas_upshifts" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2973296..2973302) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2973307..2973314 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2973326..2973345 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2973335 /Source="Nicolas_upshifts" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="upshifts" CDS 2973371..2973985 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391266.1" /db_xref="EnsemblGenomes-Gn:BSU33860" /db_xref="EnsemblGenomes-Tr:CAB15391" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR021722" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG14081" /db_xref="UniProtKB/Swiss-Prot:O32245" /translation="MFKKIAADALGLSDIGKIIEPQDYDKTDADDYVMHEDNEKIYFL IKTKADEYCFTNLALIHVDGERATSSKRTLKRYPYSQYKISDVFLETAGKVDLDVEIK FKLGGEQFDIDVHKDQIEKLKDLYKALLRIAETTYENDILINQAEQSLDKAVTILHHT RPEHVNIETQYKELTEFGFTWLTSVRSQYHIKDFGDVFEKYINN*" /label="yvbH CDS" gene 2973371..2973985 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /label="yvbH gene" downshifts 2973971 /Source="Nicolas_upshifts" /id="D1759" /incds=0 /nref=110 /ntot=197 /MaxReadThrough="2.66824" /MaxDrop="5.86088" /score="-4.16829989" /energy="-7.9" /TU="U2670" /idTUdmin="U2668" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 2974039..2974042 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2974057..2974076 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2974065 /Source="Nicolas_upshifts" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="upshifts" CDS 2974117..2974815 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391267.1" /db_xref="EnsemblGenomes-Gn:BSU33870" /db_xref="EnsemblGenomes-Tr:CAB15392" /db_xref="GOA:O32246" /db_xref="InterPro:IPR029038" /db_xref="SubtiList:BG14082" /db_xref="UniProtKB/Swiss-Prot:O32246" /translation="MYCPQCGHQTDGGNFCEKCGSPLPGQSGHQHAAQTGAAAKQAAK QFGSFVLSVLKRPYQECKATGGEQLISAIITMVLFSLLTPLMFYILFSDGPGSVSFTA IFLEPTIYFILFLFGLHACIFFALKIAGNQVSFKDSFSRFGAFLIPFTAILILALFFF LLHTDICFTILAVGLIGAFFAIPPAMLSSYQHSYKGKVDFIYSTIVIYLIICVTFQLI IEHYVKEIFRYMLF*" /label="yvbI CDS" gene 2974117..2974815 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /label="yvbI gene" downshifts 2974788 /Source="Nicolas_upshifts" /id="D1760" /incds=0 /nref=72 /ntot=203 /MaxReadThrough="1.50622" /MaxDrop="4.71846" /score="17.2112529" /energy="-17.2" /TU="U2671" /idTUdmin="U2671" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(2974851..2976668) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15155184" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391268.1" /db_xref="EnsemblGenomes-Gn:BSU33880" /db_xref="EnsemblGenomes-Tr:CAB15393" /db_xref="GOA:O32247" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR026870" /db_xref="SubtiList:BG14083" /db_xref="UniProtKB/Swiss-Prot:O32247" /translation="MLFCKNCGSQNNEGAKFCKQCGTPIGGGSKQANQETASTAETRQ APRKPIPKKTIILWSSIAAACVILFAAYKTGAYFTSKDRLVDKFEQAVNDGDQDQIAT LLTPVNDNLKLTKNNVKPFLTYLKDHPDKKDELFASLRDETAQKDIVYAEKDGKSLLV FDHYDLKVAPVYFEVSSNYKNTDLYVNKEEAGSVKKADQAQTLGPYIPGEYTVSAKLK NDVVDLVKKEDIQAIGDSSFRVDLSLEADDVTFSLANDIKSGKGDLLINGKSIHKDPF KSVTYGPLLTDGSMTASVEAEFPWGKTKTAGVPIDDKEMELTLIPDQDTQEQIMNTIV KTTKQYSKALSDGNTAQMTEASANWKAETKDTVDSMKSADSYLKDRYLETDFDLDTFA LSQKNDGTWQVSVTGKELHQSSSYNDYTKSEMTDDSPSYEYLLSYDKKQKKWIFEDAE STFESAGTNIKKIKNDKPETYTSAWAGSKNKGSESSASGDVTDEQVTLFMGSYLQSQA DAVNQNNFSLMEDSLEKGSSLYSDQQHLVSKLNKEGTTEDFNNYEVKSWSQNGSAITI KTYEEFYITKSGGSPKLRTYNWTYTGVVKNGRIYLTSIQ*" /label="yvbJ CDS" gene complement(2974851..2976668) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /label="yvbJ gene" downshifts complement(2974870) /Source="Nicolas_upshifts" /id="D1761" /incds=0 /nref=31 /ntot=189 /MaxReadThrough="2.6958" /MaxDrop="3.67366" /score="15.9345511" /energy="-17.2" /TU="NA" /idTUdmin="U2673" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" downshifts complement(2975041) /Source="Nicolas_upshifts" /id="D1762" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="4.6758" /MaxDrop="2.2812" /score="15.9345511" /energy="-17.2" /TU="U2673" /idTUdmin="U2673" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" misc_feature complement(2976710..2976729) /Source="Nicolas_upshift_promotors" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 2976714..2976733 /Source="Nicolas_upshift_promotors" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2976719 /Source="Nicolas_upshifts" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2976723) /Source="Nicolas_upshifts" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2976788..2977255 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acyltransferase" /protein_id="NP_391269.1" /db_xref="EnsemblGenomes-Gn:BSU33890" /db_xref="EnsemblGenomes-Tr:CAB15394" /db_xref="GOA:O32248" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YVK" /db_xref="SubtiList:BG14084" /db_xref="UniProtKB/Swiss-Prot:O32248" /translation="MNMQKLRIELGEETNDELYDLLLLADPSKDIVDEYLERGECYTA WAGDELAGVYVLLKTRPQTVEIVNIAVKESLQKKGFGKQLVLDAIEKAKKLGADTIEI GTGNSSIHQLSLYQKCGFRIQAIDHDFFLRHYDEDIFENGIQCRDMVRLYLDL*" /label="yvbK CDS" gene 2976788..2977255 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /label="yvbK gene" downshifts 2977252 /Source="Nicolas_upshifts" /id="D1763" /incds=0 /nref=199 /ntot=250 /MaxReadThrough="1.84358" /MaxDrop="5.3321" /score="15.9040274" /energy="-13.3" /TU="U2672" /idTUdmin="U2672" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(2977300..2978592) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /EC_number="4.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enolase" /protein_id="NP_391270.1" /db_xref="EnsemblGenomes-Gn:BSU33900" /db_xref="EnsemblGenomes-Tr:CAB15395" /db_xref="GOA:P37869" /db_xref="InterPro:IPR000941" /db_xref="InterPro:IPR020809" /db_xref="InterPro:IPR020810" /db_xref="InterPro:IPR020811" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:4A3R" /db_xref="SubtiList:BG10899" /db_xref="UniProtKB/Swiss-Prot:P37869" /translation="MPYIVDVYAREVLDSRGNPTVEVEVYTETGAFGRALVPSGASTG EYEAVELRDGDKDRYLGKGVLTAVNNVNEIIAPELLGFDVTEQNAIDQLLIELDGTEN KGKLGANAILGVSMACARAAADFLQIPLYQYLGGFNSKTLPVPMMNIVNGGEHADNNV DIQEFMIMPVGAPNFREALRMGAQIFHSLKSVLSAKGLNTAVGDEGGFAPNLGSNEEA LQTIVEAIEKAGFKPGEEVKLAMDAASSEFYNKEDGKYHLSGEGVVKTSAEMVDWYEE LVSKYPIISIEDGLDENDWEGHKLLTERLGKKVQLVGDDLFVTNTKKLSEGIKNGVGN SILIKVNQIGTLTETFDAIEMAKRAGYTAVISHRSGETEDSTIADIAVATNAGQIKTG APSRTDRVAKYNQLLRIEDQLAETAQYHGINSFYNLNK*" /label="eno CDS" gene complement(2977300..2978592) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /label="eno gene" downshifts complement(2977310) /Source="Nicolas_upshifts" /id="D1764" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="2.21852" /MaxDrop="9.34136" /score="29.8674712" /energy="-15" /TU="NA" /idTUdmin="U2674" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2978622..2980157) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /EC_number="5.4.2.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9830105, 10869096, 12682299, 19193632, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9830105, 10869096, 12682299, 19193632, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate mutase" /protein_id="NP_391271.1" /db_xref="EnsemblGenomes-Gn:BSU33910" /db_xref="EnsemblGenomes-Tr:CAB15396" /db_xref="GOA:P39773" /db_xref="InterPro:IPR005995" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR011258" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR036646" /db_xref="SubtiList:BG10898" /db_xref="UniProtKB/Swiss-Prot:P39773" /translation="MSKKPAALIILDGFGLRNETVGNAVALAKKPNFDRYWNQYPHQT LTASGEAVGLPEGQMGNSEVGHLNIGAGRIVYQSLTRVNVAIREGEFERNQTFLDAIS NAKENNKALHLFGLLSDGGVHSHINHLFALLKLAKKEGLTKVYIHGFLDGRDVGPQTA KTYINQLNDQIKEIGVGEIASISGRYYSMDRDKRWDRVEKAYRAMAYGEGPSYRSALD VVDDSYANGIYDEFVIPSVITKENGEPVAKIQDGDSVIFYNFRPDRAIQISNTFTNKD FRDFDRGENYPKNLYFVCLTHFSETVDGYVAFKPINLDNTVGEVLSQHGLKQLRIAET EKYPHVTFFMSGGREAEFPGEERILINSPKVATYDLKPEMSAYEVKDALVKEIEADKH DAIILNFANPDMVGHSGMVEPTIKAIEAVDECLGEVVDAILAKGGHAIITADHGNADI LITESGEPHTAHTTNPVPVIVTKEGITLREGGILGDLAPTLLDLLGVEKPKEMTGTSL IQK*" /label="pgm CDS" gene complement(2978622..2980157) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /label="pgm gene" CDS complement(2980150..2980911) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /EC_number="5.3.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8021172, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="triose phosphate isomerase" /protein_id="NP_391272.1" /db_xref="EnsemblGenomes-Gn:BSU33920" /db_xref="EnsemblGenomes-Tr:CAB15397" /db_xref="GOA:P27876" /db_xref="InterPro:IPR000652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020861" /db_xref="InterPro:IPR022896" /db_xref="InterPro:IPR035990" /db_xref="SubtiList:BG10897" /db_xref="UniProtKB/Swiss-Prot:P27876" /translation="MRKPIIAGNWKMNKTLGEAVSFVEEVKSSIPAADKAEAVVCAPA LFLEKLASAVKGTDLKVGAQNMHFEESGAFTGEISPVALKDLGVDYCVIGHSERREMF AETDETVNKKAHAAFKHGIVPIICVGETLEEREAGKTNDLVADQVKKGLAGLSEEQVA ASVIAYEPIWAIGTGKSSTAKDANDVCAHIRKTVAESFSQEAADKLRIQYGGSVKPAN IKEYMAESDIDGALVGGASLEPQSFVQLLEEGQYE*" /label="tpiA CDS" gene complement(2980150..2980911) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /label="tpiA gene" CDS complement(2980942..2982126) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /EC_number="2.7.2.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559176, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559176, 12682299, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate kinase" /protein_id="NP_391273.1" /db_xref="EnsemblGenomes-Gn:BSU33930" /db_xref="EnsemblGenomes-Tr:CAB15398" /db_xref="GOA:P40924" /db_xref="InterPro:IPR001576" /db_xref="InterPro:IPR015824" /db_xref="InterPro:IPR015911" /db_xref="InterPro:IPR036043" /db_xref="SubtiList:BG11062" /db_xref="UniProtKB/Swiss-Prot:P40924" /translation="MNKKTLKDIDVKGKVVFCRVDFNVPMKDGEVTDDTRIRAALPTI KHLADQGAKVLLASHLGRPKGEVVEELRLTPVAARLGELLGKEVKKADEAYGDAVKAQ ISEMKDGDVLVLENVRFYPGEEKNDPELAKAFAELADVYVNDAFGAAHRAHASTAGIA EHLPAVAGFLMEKELDVLGKAVSNPDRPFTAIIGGAKVKDKIGVIESLLDKVDNLIIG GGLAYTFVKALGYEVGKSLLEEDKIELAKSFMDRAKEKGVNFYMPEDVLVADDFSNDA NVKIVPISEIPSDLEAIDIGTKTRETYADVIKNSKLVVWNGPMGVFEIDLFAQGTKAV AEALAEAKDTYSVIGGGDSAAAVEKFGLADKMSHISTGGGASLEFMEGKELPGVAALN DK*" /label="pgk CDS" gene complement(2980942..2982126) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /label="pgk gene" S_feature complement(2982127..2982367) /Source="Nicolas_S_feature" /locus_tag="new_3481382_3481622_c" /HighExp="Lbstat, Lbtran, C90, LBGtran, LBGexp, G150, M40t45, LPhT, M0t45, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA, SigK" /TUshortPSig="0.979, 0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1300" upshifts complement(2982367) /Source="Nicolas_upshifts" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2982369..2982442) /Source="Nicolas_S_feature" /locus_tag="new_3481624_3481697_c" /HighExp="C90, LBGtran, Lbstat, LBGexp, Lbtran, G150, M40t45, Etha, ferm, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1301" promotor_-10 complement(2982381..2982400) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2982416..2982420) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2982443..2983450) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /EC_number="1.2.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NAD-dependent, glycolytic)" /protein_id="NP_391274.1" /db_xref="EnsemblGenomes-Gn:BSU33940" /db_xref="EnsemblGenomes-Tr:CAB15399" /db_xref="GOA:P09124" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10827" /db_xref="UniProtKB/Swiss-Prot:P09124" /translation="MAVKVGINGFGRIGRNVFRAALNNPEVEVVAVNDLTDANMLAHL LQYDSVHGKLDAEVSVDGNNLVVNGKTIEVSAERDPAKLSWGKQGVEIVVESTGFFTK RADAAKHLEAGAKKVIISAPANEEDITIVMGVNEDKYDAANHDVISNASCTTNCLAPF AKVLNDKFGIKRGMMTTVHSYTNDQQILDLPHKDYRRARAAAENIIPTSTGAAKAVSL VLPELKGKLNGGAMRVPTPNVSLVDLVAELNQEVTAEEVNAALKEAAEGDLKGILGYS EEPLVSGDYNGNKNSSTIDALSTMVMEGSMVKVISWYDNESGYSNRVVDLAAYIAKKG L*" /label="gapA CDS" gene complement(2982443..2983450) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /label="gapA gene" promotor_-35 2983369..2983372 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2983389..2983391 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2983391 /Source="Nicolas_upshifts" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2983497..2984519) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489127, 12622823, 17142398, 17293407, 18052209, 18554327" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489127, 12622823, 17142398, 17293407, 18052209, 18554327; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of gapA" /protein_id="NP_391275.1" /db_xref="EnsemblGenomes-Gn:BSU33950" /db_xref="EnsemblGenomes-Tr:CAB15400" /db_xref="GOA:O32253" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OKG" /db_xref="PDB:3BXE" /db_xref="PDB:3BXF" /db_xref="PDB:3BXG" /db_xref="PDB:3BXH" /db_xref="SubtiList:BG14085" /db_xref="UniProtKB/Swiss-Prot:O32253" /translation="MNQLIQAQKKLLPDLLLVMQKRFEILQYIRLTEPIGRRSLSASL GISERVLRGEVQFLKEQNLVDIKTNGMTLTEEGYELLSVLEDTMKDVLGLTLLEKTLK ERLNLKDAIIVSGDSDQSPWVKKEMGRAAVACMKKRFSGKNIVAVTGGTTIEAVAEMM TPDSKNRELLFVPARGGLGEDVKNQANTICAHMAEKASGTYRLLFVPGQLSQGAYSSI IEEPSVKEVLNTIKSASMLVHGIGEAKTMAQRRNTPLEDLKKIDDNDAVTEAFGYYFN ADGEVVHKVHSVGMQLDDIDAIPDIIAVAGGSSKAEAIEAYFKKPRNTVLVTDEGAAK KLLRDE*" /label="cggR CDS" gene complement(2983497..2984519) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /label="cggR gene" upshifts complement(2983513) /Source="Nicolas_upshifts" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2983541..2983542) /Source="Nicolas_upshift_promotors" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2984520..2984631) /Source="Nicolas_S_feature" /locus_tag="new_3483775_3483886_c" /HighExp="LPhT, C90, LBGtran, Heat, BI, LBGexp, Lbstat, Sw, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1302" downshifts 2984557 /Source="Nicolas_upshifts" /id="D1765" /incds=0 /nref=3 /ntot=50 /MaxReadThrough="4.48989" /MaxDrop="5.24842" /score="-9.71393179" /energy="-11.8" /TU="NA" /idTUdmin="U2675" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2984612..2984631) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2984631) /Source="Nicolas_upshifts" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2984633..2984743) /Source="Nicolas_S_feature" /locus_tag="new_3483888_3483998_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, S3, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1303" promotor_-35 complement(2984645..2984652) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2984726..2984745) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-10" upshifts complement(2984741) /Source="Nicolas_upshifts" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="upshifts" promotor_-35 complement(2984758..2984767) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-35" CDS complement(2984817..2986211) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9620981, 10417639, 15849754, 16850406, 20693325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620981, 10417639, 15849754, 16850406, 20693325; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arabinose-related compounds permease" /protein_id="NP_391276.1" /db_xref="EnsemblGenomes-Gn:BSU33960" /db_xref="EnsemblGenomes-Tr:CAB15401" /db_xref="GOA:P96710" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11907" /db_xref="UniProtKB/Swiss-Prot:P96710" /translation="MKNTPTQLEPNVPVTRSHSMGFVILISCAAGLGGLLYGYDTAVI SGAIGFLKDLYSLSPFMEGLVISSIMIGGVVGVGISGFLSDRFGRRKILMTAALLFAI SAIVSALSQDVSTLIIARIIGGLGIGMGSSLSVTYITEAAPPAIRGSLSSLYQLFTIL GISATYFINLAVQRSGTYEWGVHTGWRWMLAYGMVPSVIFFLVLLVVPESPRWLAKAG KTNEALKILTRINGETVAKEELKNIENSLKIEQMGSLSQLFKPGLRKALVIGILLALF NQVIGMNAITYYGPEIFKMMGFGQNAGFVTTCIVGVVEVIFTVIAVLLIDKVGRKKLM SIGSAFMAIFMILIGTSFYFELTSGIMMIVLILGFVAAFCVSVGPITWIMISEIFPNH LRARAAGIATIFLWGANWAIGQFVPMMIDSFGLAYTFWIFAVINILCFLFVVTICPET KNKSLEEIEKLWIK*" /label="araE CDS" gene complement(2984817..2986211) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /label="araE gene" downshifts complement(2984831) /Source="Nicolas_upshifts" /id="D1766" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="1.15614" /MaxDrop="3.28809" /score="1.06999853" /energy="-14.6" /TU="NA" /idTUdmin="U2679" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2986310..2986329) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2986324) /Source="Nicolas_upshifts" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2986344..2986351) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2986351..2986358 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2986372..2986391 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2986378 /Source="Nicolas_upshifts" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="upshifts" CDS 2986415..2987503 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the ara regulon (LacI family)" /protein_id="NP_391277.2" /db_xref="EnsemblGenomes-Gn:BSU33970" /db_xref="EnsemblGenomes-Tr:CAB15402" /db_xref="GOA:P96711" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR028082" /db_xref="InterPro:IPR033532" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3TB6" /db_xref="PDB:4EGY" /db_xref="PDB:4EGZ" /db_xref="PDB:4H0E" /db_xref="PDB:5D4R" /db_xref="PDB:5D4S" /db_xref="SubtiList:BG11913" /db_xref="UniProtKB/Swiss-Prot:P96711" /translation="MLPKYAQVKEEISSWINQGKILPDQKIPTENELMQQFGVSRHTI RKAIGDLVSQGLLYSVQGGGTFVASRSAKSALHSNKTIGVLTTYISDYIFPSIIRGIE SYLSEQGYSMLLTSTNNNPDNERRGLENLLSQHIDGLIVEPTKSALQTPNIGYYLNLE KNGIPFAMINASYAELAAPSFTLDDVKGGMMAAEHLLSLGHTHMMGIFKADDTQGVKR MNGFIQAHRERELFPSPDMIVTFTTEEKESKLLEKVKATLEKNSKHMPTAILCYNDEI ALKVIDMLREMDLKVPEDMSIVGYDDSHFAQISEVKLTSVKHPKSVLGKAAAKYVIDC LEHKKPKQEDVIFEPELIIRQSARKLNE*" /label="araR CDS" gene 2986415..2987503 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /label="araR gene" downshifts 2987483 /Source="Nicolas_upshifts" /id="D1767" /incds=0 /nref=202 /ntot=247 /MaxReadThrough="1.17419" /MaxDrop="4.76041" /score="20.2322165" /energy="-13.6" /TU="NA" /idTUdmin="U2680" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2987552..2988562) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_391278.1" /db_xref="EnsemblGenomes-Gn:BSU33980" /db_xref="EnsemblGenomes-Tr:CAB15403" /db_xref="GOA:O32254" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG14086" /db_xref="UniProtKB/Swiss-Prot:O32254" /translation="MSNNQRKDTLLSVLNLSPVVQGGTIAESFRNSMDLARRAEEWGY HRYWLAEHHNIEGVASSATAVLIGHIAGGTKKIRVGSGGIMLPNHSSLVIAEQFGTLE TLYPGRIDLGLGRAPGTDQLTARALRRNINSGEDFPEQLEELRNYFKPSGNVRNQVRA IPGEGIDVPIWLLGSSGFSARLAGELGLPFAFAAHFSPANTVPALELYRNSFTPSDVL DEPYAMVGVTIIAADTNEKAQHLATSHYQRFLDLVRGTPNQLKPPVEDMDQIWSPYEK AMVNEQLSSTIVGGPEEVKAKLEDFVKTTQADEIMVNSETFEHADRMRSFEIIADVWK NR*" /label="yvbT CDS" gene complement(2987552..2988562) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /label="yvbT gene" downshifts complement(2987559) /Source="Nicolas_upshifts" /id="D1768" /incds=0 /nref=200 /ntot=252 /MaxReadThrough="1.53983" /MaxDrop="7.63266" /score="27.2032847" /energy="-14.2" /TU="NA" /idTUdmin="U2681" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2988563..2988640) /Source="Nicolas_S_feature" /locus_tag="new_3487818_3487895_c" /HighExp="dia5, dia15, Diami, H2O2, Salt, Paraq, G180, Etha, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1304" promotor_-10 complement(2988630..2988649) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2988640) /Source="Nicolas_upshifts" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2988663..2988670) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2988719..2989597) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391279.1" /db_xref="EnsemblGenomes-Gn:BSU33990" /db_xref="EnsemblGenomes-Tr:CAB15404" /db_xref="GOA:O32255" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14087" /db_xref="UniProtKB/Swiss-Prot:O32255" /translation="MTITQLKVFVKIAETGSFTKAGQALNMTQPAVSHAISAIEAELD VKLIIRDRRNGLMLTDTGKQILVHIREVLKGIEKVEQVAAAEKGLELGTIHIGTFSTA SAYFMPKLISEFKQKYPKLELVLHEGTVNEVKEWLHTRMIDVGILLYPTEEMEYIHLK KDKMAVVLRDDHPLASHSAITLKDLDHEPMIVCDGGYESPFIDMFRQAGATLHPAFTV YNINTSISMIREGLGLAILSEMSMSGMPLPEHVVTRELDPQVYRDVQLAVPSLKEASL AAKLFIEMAKELFGAE*" /label="yvbU CDS" gene complement(2988719..2989597) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /label="yvbU gene" promotor_-35 2989255..2989261 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2989276..2989287 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2989287 /Source="Nicolas_upshifts" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2989631..2989638 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2989644..2989663) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-10" upshifts complement(2989649) /Source="Nicolas_upshifts" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="upshifts" promotor_-10 2989652..2989671 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2989654 /Source="Nicolas_upshifts" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2989677..2989681) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-35" CDS 2989697..2990614 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10844694, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cysteine and O-acetylserine efflux permease" /protein_id="NP_391280.1" /db_xref="EnsemblGenomes-Gn:BSU34000" /db_xref="EnsemblGenomes-Tr:CAB15405" /db_xref="GOA:O32256" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG14088" /db_xref="UniProtKB/Swiss-Prot:O32256" /translation="MKQLPKTRTALLLAFLVIMWGVNWPLSKAALAYSPPLLFAGIRT LIGGLLLVIVALPRIHKLRLKETWPIYLVSALLNITLFYGLQTIGLNYLPAGLFSAIV FFQPVLMGVFSWLWLGESMFVMKVIGLILGFAGVAVISAAGFGGHISVIGVLLALGSA VSWALGTVYMKKTGSRVDSIWMVALQLTIGSVFLLISGFWTESFSAIQWTAPFITSLL FISVFVIALGWLVFFTLVGSGEASKVASYTFLIPLISIVASSIFLHEPLTLSLLAGLL LIVTSICLVNTKSKAQKAAAIGINEKAAQ*" /label="cyeB CDS" gene 2989697..2990614 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /label="cyeB gene" downshifts 2990603 /Source="Nicolas_upshifts" /id="D1769" /incds=0 /nref=6 /ntot=15 /MaxReadThrough="2.97475" /MaxDrop="3.548" /score="22.9557936" /energy="-19.2" /TU="NA" /idTUdmin="U2684" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2990655..2991998) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19258532, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative leucine permease" /protein_id="NP_391281.1" /db_xref="EnsemblGenomes-Gn:BSU34010" /db_xref="EnsemblGenomes-Tr:CAB15406" /db_xref="GOA:O32257" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG14089" /db_xref="UniProtKB/Swiss-Prot:O32257" /translation="MKNDNQTLKRTMTSRHIMMMALGGAIGAGLFKGSSSAIDVAGPS VIIAYLLGGIILLFIMQGLAEMAVRNRNARTFRDLVQQVLGNYAAYFLDWIYWKMWVL NIAAEAVVAAIFIQYWLPGCPIWVLALGISLIVTIVNLLSVKIFAETEYWLAMIKITV IIIFIILGLLLLFVSFGDHTASGFSNLTDHGGFFPHGGTGLITAMLVVIYSYGGTEII GVTLAETKNPEKVVPKAVRSTLTRIVAFYLLPFFIIVSLIPWNQVNSVPESPFVMVFK MVGIPGADHIMNAVILLAIISSMNSGLYGSSRILYTQASDGRLPKVFSKLSSKNVPMF AILMCTSSLYIGVLISLFAGSQTFNYLMGSLGYTVLFIWLIIGFAHLKSRKQQTETPA YYVKWFPYTTWFAIVALLAILIGVIMTTSIVITGITAAIYLLITVAYLVKGRKHQ*" /label="yvbW CDS" gene complement(2990655..2991998) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /label="yvbW gene" misc_RNA complement(2992067..2992302) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /product="T-box riboswitch controlling synthesis of an amino acid transporter" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 18625071, 19258532; Product type n: RNA" /function="16.3: Control" /label="tboX RNA" gene complement(2992067..2992302) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /label="tboX gene" downshifts complement(2992201) /Source="Nicolas_upshifts" /id="D1770" /incds=1 /nref=1 /ntot=104 /MaxReadThrough="5.18182" /MaxDrop="2.29735" /score="33.4262209" /energy="-24.4" /TU="U2685,U2689" /idTUdmin="U2689" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2992303..2992399) /Source="Nicolas_S_feature" /locus_tag="new_3491558_3491654_c" /HighExp="Cold, GM 120, C30, GM 90, C90, GM 15, GM 10, GM 25, HPh, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1305" CDS complement(2992400..2993434) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12177332; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative epimerase modification of peptidoglycan" /protein_id="NP_391282.1" /db_xref="EnsemblGenomes-Gn:BSU34020" /db_xref="EnsemblGenomes-Tr:CAB15407" /db_xref="GOA:O32258" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG14090" /db_xref="UniProtKB/Swiss-Prot:O32258" /translation="MKKWLIIAVSLAIAIVLFMYTKGEAKAAGMTVGYTTGDTASYNS LTKYHTYMNAIATDTFAFEKNGQIIGDAPTKQLTYAKKKKIKTWAVISNYNDAIYDFD GDLASRVMSNKTAKKRFTDQLITLAKKHSYYGINIDFEAVNPEDRAAYSNFIQYVSQA LNKKHIKTMVSVPAKSADDKNDDWSWPYDYAKIGKYADFVQVMTYDEHGIWGEPGSVA STNWIKSSLQFSVKKIKANKVIMGIPAYGYDWDVKDGSTSTIREWNELKSLIKKQKAK PAFNKKSGSMTFSYVDKKKHKHVVWYENEKTVQTKSHLAKQYKIAGVSVYALGNESES FWKAIRKGTK*" /label="yvbX CDS" gene complement(2992400..2993434) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /label="yvbX gene" promotor_-10 complement(2993456..2993474) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2993462) /Source="Nicolas_upshifts" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2993487..2993494) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2993542..2994264) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22427629, 24196425, 24274019" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22427629, 24196425, 24274019; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase for L-lactate utilization" /protein_id="NP_391283.1" /db_xref="EnsemblGenomes-Gn:BSU34030" /db_xref="EnsemblGenomes-Tr:CAB15408" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR022823" /db_xref="SubtiList:BG14091" /db_xref="UniProtKB/Swiss-Prot:O32259" /translation="MTKGTIQNQESFLNRIASSLGRERRTGGVAVPEWAHQPQYKTLE GYSADDLVTVLKNHCVKIHTELIETDSTGLYDALREQVSRFSGGPVIIPKDPRFEEYG LKSLLTKDWPSEGTPVWEWDADKGEENIKKAEQANVGITFSEITLAESGTVVLFSSKD IGRSVSLLPTTYIAIVPKSSIVPRMTQASDIIRQNIANGVTVPSCINYITGPSNSADI EMDLVVGVHGPVKAAYILVSDR*" /label="lutC CDS" gene complement(2993542..2994264) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /label="lutC gene" downshifts complement(2993558) /Source="Nicolas_upshifts" /id="D1771" /incds=0 /nref=194 /ntot=266 /MaxReadThrough="4.5919" /MaxDrop="7.41457" /score="25.5917046" /energy="-15.7" /TU="U2689" /idTUdmin="U2689" /TUdmin="-1423" /isTUend="FALSE" /label="downshifts" CDS complement(2994264..2995703) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase linked to L-lactate utilization" /protein_id="NP_391284.1" /db_xref="EnsemblGenomes-Gn:BSU34040" /db_xref="EnsemblGenomes-Tr:CAB15409" /db_xref="GOA:O07021" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR004452" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR022825" /db_xref="InterPro:IPR024569" /db_xref="SubtiList:BG12448" /db_xref="UniProtKB/Swiss-Prot:O07021" /translation="MAMKIGTDAFKERVSQGIDNEFMRGAVSGAQERLRTRRLEAAEE LGNWEEWRSLSEEIRQHVLENLDFYLGQLAENVAKRGGHVYFAKTAEEASSYIRDVIQ KKNGKKIVKSKSMVTEEINLNEVLEKEGCEVVETDLGEYILQIDDHDPPSHIVAPALH KNKEQIRDVFKERLDYQHTEKPEELVMHARAILRKKFLEADIGITGCNFAIADTGSVS LVTNEGNGRLVSTLPKTQITVMGMERIVPSFSEFEVLVSMLTRSAVGQRLTSYITALT GPKLEGEVDGPEEFHLVIVDNGRSNILGTEFQSVLQCIRCAACINVCPVYRHVGGHSY GSIYSGPIGAVLSPLLGGYDDYKELPYASSLCAACSEACPVKIPLHELLLKHRQNIVE KEGRAPISEKLAMKAFGLGASSLSLYKMGSKWAPAAMTPFTEDEKISKGPGPLKNWTQ IRDFPAPHKSRFRDWFADRETSERTKEEQ*" /label="lutB CDS" gene complement(2994264..2995703) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /label="lutB gene" promotor_-35 2995251..2995254 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2995271 /Source="Nicolas_upshifts" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2995272..2995276 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2995425 /Source="Nicolas_upshifts" /id="D1772" /incds=1 /nref=1 /ntot=175 /MaxReadThrough="1.77859" /MaxDrop="3.31917" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2686" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts 2995579 /Source="Nicolas_upshifts" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2995580..2995581 /Source="Nicolas_upshift_promotors" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2995730..2996446) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /EC_number="1.8.98.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-sulfur oxidase subunit used in L-lactate utilization" /protein_id="NP_391285.1" /db_xref="EnsemblGenomes-Gn:BSU34050" /db_xref="EnsemblGenomes-Tr:CAB15410" /db_xref="GOA:O07020" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR022822" /db_xref="SubtiList:BG12447" /db_xref="UniProtKB/Swiss-Prot:O07020" /translation="MKVSLFVTCLVDMFQTNVGKATVELLERLGCEVDFPEGQICCGQ PAYNSGYVHDAKKAMKRMIETFQDSEYVVSPSGSCTTMFREYPHLFQDDPKWADKAKK LADKTYELTDFIVNVLGVEDVGATLHTKATLHTSCHMTRLLGVRKEPMKLLSHVKGLQ FTELPGKHNCCGFGGTFSVKMAQISEQMVDEKVECVEETGAEVLIGADCGCLMNIGGR LGRKDKNVKVMHIAEVLNSR*" /label="lutA CDS" gene complement(2995730..2996446) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /label="lutA gene" promotor_-35 2996350..2996357 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2996371..2996373 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2996371 /Source="Nicolas_upshifts" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2996444 /Source="Nicolas_upshifts" /id="D1773" /incds=0 /nref=15 /ntot=169 /MaxReadThrough="1.96527" /MaxDrop="4.662" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2688" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" S_feature complement(2996447..2996513) /Source="Nicolas_S_feature" /locus_tag="new_3495702_3495768_c" /HighExp="C90, M40t90, T3.0H, T4.0H, HiOs, T1.0H, T3.30H, T2.30H, Lbstat, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1306" promotor_-10 complement(2996510..2996529) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-10" upshifts complement(2996513) /Source="Nicolas_upshifts" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="upshifts" promotor_-35 complement(2996544..2996551) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-35" CDS complement(2996621..2997223) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvfT]" /protein_id="NP_391286.1" /db_xref="EnsemblGenomes-Gn:BSU34060" /db_xref="EnsemblGenomes-Tr:CAB15411" /db_xref="GOA:O07019" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12446" /db_xref="UniProtKB/Swiss-Prot:O07019" /translation="MIRLFIAEDQRMLLGALGSLLDLEEDMTVIGQALNGEEALHAIL KLEPDVCIMDIEMPVRSGLNVAEELMKKGCVSKVIILTTFARPGYFERAVKAGAHGYL LKDGEIDDLADAIRKCVKGKRVFSPELTFNMMRDENPLTVREQEILRLAALGKTTKDI TLELYLSQGTVRNYISEIIQKLNAKNRTEAASIAEEKGWI*" /label="yvfU CDS" gene complement(2996621..2997223) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /label="yvfU gene" CDS complement(2997240..2998355) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YvfU]" /protein_id="NP_391287.2" /db_xref="EnsemblGenomes-Gn:BSU34070" /db_xref="EnsemblGenomes-Tr:CAB15412" /db_xref="GOA:Q795K2" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12445" /db_xref="UniProtKB/Swiss-Prot:Q795K2" /translation="MKKAISIFPKEFGFFPYIFLVYTIMPFLSLLKESGVKQGIGYGM LLLFVAAYRQLFCSVGKASFTYWLIVQMAVILMYSVFYNITYIYLGFFPANFVGYYKE KTNFNRAFCALIFILLFPCLYQFIANSVSLRELFSVLPFLVIMLISPFGIRSMFRRIE LEAKLAQANEQIKELSKREERVRIARDLHDTLGHTLSLLTLKSQLIQRLAASDPERTK LEAKEMETSSRSALKQVRELVSDMRTVTITEELVNIQHILRAGNITFQYEGADDFSVI SPVTQNIISMCMREAVTNIIKHSKATHCAITISQFADKMRIVIRDDGKGAPKEKMFGN GLWGMEERLMLIEGGLTVSDHNGTVVALTIPLIKKAE*" /label="yvfT CDS" gene complement(2997240..2998355) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /label="yvfT gene" CDS complement(2998359..2999096) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391288.1" /db_xref="EnsemblGenomes-Gn:BSU34080" /db_xref="EnsemblGenomes-Tr:CAB15413" /db_xref="GOA:O07017" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12444" /db_xref="UniProtKB/Swiss-Prot:O07017" /translation="MNVLQKQSIAEMKRVLRNKYFVLWSLIMPIAFYYFFTNVVNTNV PDQRAWEAHYLMSMTVFSVMGSSIMTLGIRMVQERSQGWAAFIRLTPLPDHIYLSAQM IGQSVIHVLSITVIFLFGAIINDIALSPFEWMMSGLWILFGALPFLALGTLIGLMRKV ETAAGISNVLYMLLALGGGMWMPFEVMPDMMQSIGQWLPSYHFGSGAWELVRGGSPTW KNILILIAYMMLFMLLSKYIRRKQEAV*" /label="yvfS CDS" gene complement(2998359..2999096) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /label="yvfS gene" promotor_-10 complement(2998385..2998404) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-10" upshifts complement(2998399) /Source="Nicolas_upshifts" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="upshifts" promotor_-35 complement(2998416..2998423) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-35" CDS complement(2999097..3000002) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_391289.1" /db_xref="EnsemblGenomes-Gn:BSU34090" /db_xref="EnsemblGenomes-Tr:CAB15414" /db_xref="GOA:O07016" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12443" /db_xref="UniProtKB/Swiss-Prot:O07016" /translation="MMKEAVTVSNVTKHFQRKTAVNNISFSIEKGEIAAILGPNGAGK TTVVSMILGLLKPSEGEIKLFNRVPDDQQVREKIGVMLQEVSVMPGLKVDEILELFRS YYPNPLSMKELVSLTALTKEDLKTRAEKLSGGQKRRLSFALALAGNPELLILDEPTVG MDTSSRHRFWQTIHGLSDQGKTIIFSTHYLQEADDAAQRILFFTEGQLVADGSPMQIR SRIQKQSVSFTLHSSESLERLSCHPEVERVIHEHERTIIQTSNTDKVLALIFQENIHA RDIRIEQATLDEAFRQLADGNREAM*" /label="yvfR CDS" gene complement(2999097..3000002) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /label="yvfR gene" promotor_-10 complement(3000022..3000040) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3000033) /Source="Nicolas_upshifts" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3000056..3000059) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3000211..3000218 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3000229..3000248 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3000236 /Source="Nicolas_upshifts" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="upshifts" CDS 3000286..3001095 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11591687, 12620626, 15632289, 21980452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591687, 12620626, 15632289, 21980452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of RsbP phosphatase" /protein_id="NP_391290.1" /db_xref="EnsemblGenomes-Gn:BSU34100" /db_xref="EnsemblGenomes-Tr:CAB15415" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR031143" /db_xref="PDB:1WOM" /db_xref="PDB:1WPR" /db_xref="SubtiList:BG12442" /db_xref="UniProtKB/Swiss-Prot:O07015" /translation="MNEAILSRNHVKVKGSGKASIMFAPGFGCDQSVWNAVAPAFEED HRVILFDYVGSGHSDLRAYDLNRYQTLDGYAQDVLDVCEALDLKETVFVGHSVGALIG MLASIRRPELFSHLVMVGPSPCYLNDPPEYYGGFEEEQLLGLLEMMEKNYIGWATVFA ATVLNQPDRPEIKEELESRFCSTDPVIARQFAKAAFFSDHREDLSKVTVPSLILQCAD DIIAPATVGKYMHQHLPYSSLKQMEARGHCPHMSHPDETIQLIGDYLKAHV*" /label="rsbQ CDS" gene 3000286..3001095 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /label="rsbQ gene" CDS 3001131..3002342 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /EC_number="3.1.3.3" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine protein-phosphatase" /protein_id="NP_391291.1" /db_xref="EnsemblGenomes-Gn:BSU34110" /db_xref="EnsemblGenomes-Tr:CAB15416" /db_xref="GOA:O07014" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG12441" /db_xref="UniProtKB/Swiss-Prot:O07014" /translation="MDKQLNDAPCGFLALSEEGSIIAANRTLIKILDYEPEQVIGQHM NMMLTIPAQLFCQLYFFPLLKLEHHIEEIYISLKARDGEEIPVLINAIARHDSGASVF DCVLIPMRKRNEYENELLIARNEAQEALLAKQKANAELEIALETLKAKQEELLEINKQ NQQFKLNTKRELELARKIQKNSLTEPIVNDQVQIDSYYNASSELSGDLYGYYQIDEHR YGIIILDVMGHGISSALITMSLHPLFQRQITQGLSPVKVMKELDRHLHSLFQNDEEAR HYCTAIYLEIDIARQRIDYVNAGHPPALWQDDSGTQHLLHATSPPIGMFEDLEFQSSS LSYTEDGRLLLYTDGVMDPTASCYLFDLLKDHPDSPIADLKEKILTSLQHQKEAHHKS DDECFILVDVK*" /label="rsbP CDS" gene 3001131..3002342 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /label="rsbP gene" downshifts 3002329 /Source="Nicolas_upshifts" /id="D1774" /incds=0 /nref=181 /ntot=246 /MaxReadThrough="0.90827" /MaxDrop="5.41923" /score="26.3528321" /energy="-17.8" /TU="NA" /idTUdmin="U2692" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3002396..3003685) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11682178, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,4-galactanase" /protein_id="NP_391292.2" /db_xref="EnsemblGenomes-Gn:BSU34120" /db_xref="EnsemblGenomes-Tr:CAB15417" /db_xref="GOA:O07013" /db_xref="InterPro:IPR011683" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12440" /db_xref="UniProtKB/Swiss-Prot:O07013" /translation="MKSKVKMFFAAAIVWSACSSTGYAAAIEKEKHVSELRAEDLFVK KVEGMNKDFIKGADVSSVIALENSGVTFYNTNGKRQDIFTTLKQAGVNYVRVRIWNHP YDSNGNGYGGGNNDVQKAIEIGKRATANGMKVLADFHYSDFWADPAKQKVPKAWANLS FEAKKAKLYEYTKQSLQKMIKEGVDIGMVQVGNETTGGFAGETDWTKMCQLFNEGSRA VRETNSNILVALHFTNPETAGRYSFIAETLSKNKVDYDVFASSYYPFWHGTLQNLTSV LKAVANTYGKKVMVAETSYTYTAEDGDGHGNTAPKSGQTLPYPISVQGQATAVRDVME AVANTGKAGLGVFYWEPAWIPVGPKTQIEKNKVLWETYGSGWASSYAAEYDPEDAGKW YGGSAVDNQALFDFNGHPLPSLQVFQYAESGHIPKKR*" /label="ganB CDS" gene complement(3002396..3003685) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /label="ganB gene" CDS complement(3003765..3005828) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /EC_number="3.2.1.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="short chain beta-1,4-galacto-oligosaccharides beta-galactosidase (beta-galacto-pyranoside hydrolase)" /protein_id="NP_391293.1" /db_xref="EnsemblGenomes-Gn:BSU34130" /db_xref="EnsemblGenomes-Tr:CAB15418" /db_xref="GOA:O07012" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12439" /db_xref="UniProtKB/Swiss-Prot:O07012" /translation="MMSKLEKTHVTKAKFMLHGGDYNPDQWLDRPDILADDIKLMKLS HTNTFSVGIFAWSALEPEEGVYQFEWLDDIFERIHSIGGRVILATPSGARPAWLSQTY PEVLRVNASRVKQLHGGRHNHCLTSKVYREKTRHINRLLAERYGHHPALLMWHISNEY GGDCHCDLCQHAFREWLKSKYDNSLKTLNHAWWTPFWSHTFNDWSQIESPSPIGENGL HGLNLDWRRFVTDQTISFYENEIIPLKELTPDIPITTNFMADTPDLIPYQGLDYSKFA KHVDAISWDAYPVWHNDWESTADLAMKVGFINDLYRSLKQQPFLLMECTPSAVNWHNV NKAKRPGMNLLSSMQMIAHGSDSVLYFQYRKSRGSSEKLHGAVVDHDNSPKNRVFQEV AKVGETLERLSEVVGTKRPAQTAILYDWENHWALEDAQGFAKATKRYPQTLQQHYRTF WEHDIPVDVITKEQDFSPYKLLIVPMLYLISEDTVSRLKAFTADGGTLVMTYISGVVN EHDLTYTGGWHPDLQAIFGVEPLETDTLYPKDRNAVSYRSQIYEMKDYATVIDVKTAS VEAVYQEDFYARTPAVTSHEYQQGKAYFIGARLEDQFQRDFYEGLITDLSLSPVFPVR HGKGVSVQARQDQDNDYIFVMNFTEEKQLVTFDQSVKDIMTGDILSGDLTMEKYEVRI VVNTH*" /label="ganA CDS" gene complement(3003765..3005828) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /label="ganA gene" CDS complement(3005847..3006698) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17056685, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391294.1" /db_xref="EnsemblGenomes-Gn:BSU34140" /db_xref="EnsemblGenomes-Tr:CAB15419" /db_xref="GOA:O07011" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12438" /db_xref="UniProtKB/Swiss-Prot:O07011" /translation="MLADMKVRRYIRLLFSYLLLAFMAVIIVYPLLWTAGASFNPGNS LISTSIIPKHPTFDHYKELFAGKESLQYVQWYVNSMKISLFTMAGSLLCVTFTAYAFS RFRFKGRKYALTLFLLLQMIPQFSALIALFVLAQILGMINSHWLLILLYIGGLIPMNT YLMKGYMDSIPMDLDESAKIDGASSTRIFFQIILPLSKPMAAVVAMNGFTGPLGDFVL SSTILRTPESYTLPVGLFNLVNDVMGASYTTFAAGALLISIPVAVIFIMLQKNFVSGL TAGGTKG*" /label="ganQ CDS" gene complement(3005847..3006698) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /label="ganQ gene" CDS complement(3006702..3007958) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11160890, 15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 15849754, 16850406, 17056685, 27501980; Product type t : transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391295.1" /db_xref="EnsemblGenomes-Gn:BSU34150" /db_xref="EnsemblGenomes-Tr:CAB15420" /db_xref="GOA:O32261" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12437" /db_xref="UniProtKB/Swiss-Prot:O32261" /translation="MQHRQVALLLSIIPGLGQFYNKQWIKGIVFLFLGASFFAVFGDL LNMGFWGIFTLGTEVPRDNSVFLLAEGIIAVIVTCFGLAVYYVNLRDAFQSGKQRDEN KPLSSLKEQYQHIISEGYPYVVSGPSLFILIFAVIFPILFSFALAFTNYDLYHSPPAK LIDWVGFQTFANIFTVDIWRSTFFDVLAWTVVWTLAASTLQVTLGIFLAIIVNQKDLR FKRFFRTILILPWAVPGFVTILIFAGLFNDSFGAMNHDILAFFGIDPLPWMTDANWSR LALILMQGWLGFPYIFLVSTGVLQSIPDDLYEAATIDGASVFSKLRYITLPMVFIAMA PIIITQFTFNFNNFNIIYLFNGGGPAVTGSTAGGTDILVSWIYKLTMQSSQYSLAAAL TILLSVFVISIALWQFRQTKSFKEEA*" /label="ganP CDS" gene complement(3006702..3007958) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /label="ganP gene" CDS complement(3007998..3009263) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11682178, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="polygalactose / cyclodextrin-binding lipoprotein" /protein_id="NP_391296.1" /db_xref="EnsemblGenomes-Gn:BSU34160" /db_xref="EnsemblGenomes-Tr:CAB15421" /db_xref="GOA:O07009" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12436" /db_xref="UniProtKB/Swiss-Prot:O07009" /translation="MKMAKKCSVFMLCAAVSLSLAACGPKESSSAKSSSKGSELVVWE DKEKSNGIKDAVAAFEKEHDVKVKVVEKPYAKQIEDLRMDGPAGTGPDVLTMPGDQIG TAVTEGLLKELHVKKDVQSLYTDASIQSQMVDQKLYGLPKAVETTVLFYNKDLITEKE LPKTLEEWYDYSKKTADGSKFGFLALFDQIYYAESVMSGYGGYIFGKAKDGSYNPSDI GINNEGAVKGAALIQKFYKDGLFPAGIIGEQGINVLESLFTEGKAAAIISGPWNVEAF SNAGINYGITKLPKLENGKNMSSFIGVKSYNVSAFSKNEELAQELAVFLANEKNSKTR YEETKEVPAVKSLANDPAIMKSEAARAVTEQSRFSEPTPNIPEMNEIWTPADSALQTV ATGKADPKQALDQAAETAKGQIKAKHSGK*" /label="ganS CDS" gene complement(3007998..3009263) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /label="ganS gene" promotor_-10 complement(3009295..3009314) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3009317) /Source="Nicolas_upshifts" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3009329..3009336) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3009404..3010396) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 10486575, 17056685, 27501980, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 10486575, 17056685, 27501980, 28617843; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the galactan degradation operon (GanR / beta-1,4-galactobiose)" /protein_id="NP_391297.1" /db_xref="EnsemblGenomes-Gn:BSU34170" /db_xref="EnsemblGenomes-Tr:CAB15422" /db_xref="GOA:O07008" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12435" /db_xref="UniProtKB/Swiss-Prot:O07008" /translation="MATIKDIAQEAGFSISTVSRVLNNDESLSVPDETREKIYEAAEK LNYRKKTVRPLVKHIAFLYWLTDKEELEDVYFKTMRLEVEKLAKAFNVDMTTYKIADG IESIPEHTEGFIAVGTFSDEELAFLRNLTENGVFIDSTPDPDHFDSVRPDLAQMTRKT VNILTEKGHKSIGFIGGTYKNPNTNQDEMDIREQTFRSYMREKAMLDERYIFCHRGFS VENGYRLMSAAIDTLGDQLPTAFMIAADPIAVGCLQALNEKGIAIPNRVSIVSINNIS FAKYVSPPLTTFHIDIHELCKNAVQLLLEQVQDKRRTVKTLYVGAELIVRKSMN*" /label="ganR CDS" gene complement(3009404..3010396) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /label="ganR gene" downshifts complement(3009438) /Source="Nicolas_upshifts" /id="D1775" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="1.40325" /MaxDrop="2.80992" /score="14.7399792" /energy="-8.3" /TU="NA" /idTUdmin="U2694" /TUdmin=1111 /isTUend="FALSE" /label="downshifts" S_feature complement(3010526..3010575) /Source="Nicolas_S_feature" /locus_tag="new_3509781_3509830_c" /HighExp="Sw, BC, M0t90, M40t90, B60, Lbstat, Lbtran, S2, B36, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29208099999999998" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1307" downshifts complement(3010549) /Source="Nicolas_upshifts" /id="D1776" /incds=0 /nref=88 /ntot=240 /MaxReadThrough="1.88481" /MaxDrop="5.0699" /score="7.28170345" /energy="-13.7" /TU="NA" /idTUdmin="U2694" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3010576..3011235) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18604637, 24196425, 25031425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18604637, 24196425, 25031425; Product type r: regulator" /codon_start=1 /transl_table=11 /product="L-lactate utilization global transcriptional regulator (GntR family)" /protein_id="NP_391298.2" /db_xref="EnsemblGenomes-Gn:BSU34180" /db_xref="EnsemblGenomes-Tr:CAB15423" /db_xref="GOA:O07007" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12434" /db_xref="UniProtKB/Swiss-Prot:O07007" /translation="MIKNGELKPGDKLDSVQALAESFQVSRSAVREALSALKAMGLVE MKQGEGTYLKEFELNQISQPLSAALLMKKEDVKQLLEVRKLLEIGVASLAAEKRTEAD LERIQDALKEMGSIEADGELGEKADFAFHLALADASQNELLKHLMNHVSSLLLETMRE TRKIWLFSKKTSVQRLYEEHERIYNAVAAGNGAQAEAAMLAHLTNVEDVLSGYFEENV Q*" /label="lutR CDS" gene complement(3010576..3011235) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /label="lutR gene" S_feature complement(3011236..3011341) /Source="Nicolas_S_feature" /locus_tag="new_3510491_3510596_c" /HighExp="M0t90, Lbstat, BC, M40t90, Lbtran, Sw, S2, B60, ferm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69672000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1308" promotor_-10 complement(3011333..3011352) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3011342) /Source="Nicolas_upshifts" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3011367..3011370) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3011394..3011401 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3011416..3011435 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3011416 /Source="Nicolas_upshifts" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="upshifts" S_feature 3011419..3011524 /Source="Nicolas_S_feature" /locus_tag="new_3510674_3510779" /HighExp="T1.30H, S1, T1.0H, M40t90, T2.0H, M0t90, T3.0H, T2.30H, T0.30H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1309" promotor_-10 complement(3011425..3011442) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3011429) /Source="Nicolas_upshifts" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3011450..3011456) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3011525..3013216 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25031425; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_391299.1" /db_xref="EnsemblGenomes-Gn:BSU34190" /db_xref="EnsemblGenomes-Tr:CAB15424" /db_xref="GOA:P71067" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG11875" /db_xref="UniProtKB/Swiss-Prot:P71067" /translation="MQWTQAYTPIGGNLLLSALAALVPIIFFFWALAIKRMKGYTAGL ATLGIALIIAVLVYRMPAEKALMSATQGAVYGLLPIGWIIVTSVFLYKITVKTGQFDI IRSSVLSITDDRRLQALLIAFSFGAFLEGAAGFGAPVAISAALLVGLGFNPLYAAGIC LIANTAPVAFGAIGIPITAVEGPTGIPAMEISQMVGRQLPFLSVFIPLYLIIIMSGFR KALEIWPAILVSGVSFAVVQYLSSNFLGPELPDVLSALVSMAALAVFLKWWKPKTTFR FAGEQESAASIETARTNPAAPAYRGGQIFKAWSPFLLLTAMISVWGIPSVKSALTGHY EGSAVFLKWLNAVGEKLTFSPGVPFLNNQIVNADGTPIEAVYKLEVLGSAGTAILIAA VLSKFITAISWKDWGTVFKETVQELKLPILTIASVVGFAYVTNSSGMSTTLGMTLALT GSMFTFFSPVLGWLGVFITGSDTSANLLFGNLQKVTALSVGMDPVLSVAANSSGGVTG KMISPQSIAVACAAVGLAGKESDLFRFTIKHSLFLLLLVCIITFLQHHVFSWMIP*" /label="lutP CDS" gene 3011525..3013216 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /label="lutP gene" downshifts 3013201 /Source="Nicolas_upshifts" /id="D1777" /incds=0 /nref=153 /ntot=245 /MaxReadThrough="4.82757" /MaxDrop="5.44233" /score="20.8815301" /energy="-11.7" /TU="NA" /idTUdmin="U2695" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3013243..3014553) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11274109, 12533460, 12634342, 16166551, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 12533460, 12634342, 16166551, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-54 factor (sigma-L)" /protein_id="NP_391300.1" /db_xref="EnsemblGenomes-Gn:BSU34200" /db_xref="EnsemblGenomes-Tr:CAB15425" /db_xref="GOA:P24219" /db_xref="InterPro:IPR000394" /db_xref="InterPro:IPR007046" /db_xref="InterPro:IPR007634" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10748" /db_xref="UniProtKB/Swiss-Prot:P24219" /translation="MDMKLQQVQVLKPQLTQELRQAITLLGYHSAELAEYIDELSLEN PLIERKETDTPPLSYHKTNKNRMNAQEAGLQLSNPQKTLQDALKQQSLDMNLTNTEKK IFNYLIHSLDSNGYLEEDIEEAARRLSVSAKEAEAVLAKLQSLEPAGIGARSLQECIL LQLQRLPNRNEQAEMLVSAHFDAFAQKKWKTLSVETGIPLHTIQDISDDIAALHPRPG LLFARPEQDVYIEPDIFITVKNGHIAAELNTRSFPEIDLHPQYRTLLSSGSCQDTVSY LSAKYQEWRWLSRALRQRKQTITRIINELITRQKDFFLKGRSAMKPLTLREVADCLSL HESTVSRAIKGKTIQTPYGLFEMKLFFSAKAEASGDGDASNYAVKTHLENLINQEDKT KPLSDQKLVDLLYEQHGIQISRRTVAKYRDQMNIPSSAARKRYK*" /label="sigL CDS" gene complement(3013243..3014553) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /label="sigL gene" S_feature 3013246..3014316 /Source="Nicolas_S_feature" /locus_tag="new_3512501_3513571" /HighExp="M9-stat, T1.30H, S1, Sw, T1.0H, T2.0H, T0.30H, G/S, T3.30H, T2.30H" /AntisenseName="sigL" /AntisenseCor="0.63927172079726402" /AntisenseRegPval="-31.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1310" downshifts complement(3013255) /Source="Nicolas_upshifts" /id="D1778" /incds=0 /nref=62 /ntot=219 /MaxReadThrough="2.33779" /MaxDrop="5.56948" /score="28.2409666" /energy="-11.7" /TU="NA" /idTUdmin="U2698" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 3014373..3014392 /Source="Nicolas_upshift_promotors" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3014373..3014631 /Source="Nicolas_S_feature" /locus_tag="new_3513628_3513886" /HighExp="LBGstat, LBGexp, G180, Paraq, H2O2, LBGtran, Oxctl, Lbexp, dia0, HPh" /AntisenseName="sigL" /AntisenseCor="-0.50245218771496702" /AntisenseRegPval="-17.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1311" upshifts 3014373 /Source="Nicolas_upshifts" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3014567..3014586) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3014582) /Source="Nicolas_upshifts" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3014601..3014604) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3014632..3014850 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391301.1" /db_xref="EnsemblGenomes-Gn:BSU34210" /db_xref="EnsemblGenomes-Tr:CAB15426" /db_xref="InterPro:IPR018590" /db_xref="PDB:2GSV" /db_xref="PDB:2JS1" /db_xref="SubtiList:BG11876" /db_xref="UniProtKB/Swiss-Prot:P71066" /translation="MSELFSVPYFIENLKQHIEMNQSEDKIHAMNSYYRSVVSTLVQD QLTKNAVVLKRIQHLDEAYNKVKRGESK*" /label="yvfG CDS" gene 3014632..3014850 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /label="yvfG gene" downshifts 3014829 /Source="Nicolas_upshifts" /id="D1779" /incds=0 /nref=53 /ntot=250 /MaxReadThrough="3.27525" /MaxDrop="4.21929" /score="-0.306638574" /energy="-13.4" /TU="U2697" /idTUdmin="U2697" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" SCAR join(3014857,3014864) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs26" N_region 3014858..3014863 /note="EcoR site (GAATTC)" /created_by="User" /modified_by="User" /label="IIG_Bs26" promotor_-35 3014895..3014898 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3014904 /Source="Nicolas_upshifts" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3014915..3014933 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3014949..3016418 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7828905, 15138843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7828905, 15138843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="para-nitrobenzyl esterase (intracellular esterase B)" /protein_id="NP_391319.1" /db_xref="EnsemblGenomes-Gn:BSU34390" /db_xref="EnsemblGenomes-Tr:CAB15444" /db_xref="GOA:P37967" /db_xref="InterPro:IPR000997" /db_xref="InterPro:IPR002018" /db_xref="InterPro:IPR019819" /db_xref="InterPro:IPR019826" /db_xref="InterPro:IPR029058" /db_xref="PDB:1C7I" /db_xref="PDB:1C7J" /db_xref="PDB:1QE3" /db_xref="SubtiList:BG11844" /db_xref="UniProtKB/Swiss-Prot:P37967" /translation="MTHQIVTTQYGKVKGTTENGVHKWKGIPYAKPPVGQWRFKAPEP PEVWEDVLDATAYGSICPQPSDLLSLSYTELPRQSEDCLYVNVFAPDTPSKNLPVMVW IHGGAFYLGAGSEPLYDGSKLAAQGEVIVVTLNYRLGPFGFLHLSSFNEAYSDNLGLL DQAAALKWVRENISAFGGDPDNVTVFGESAGGMSIAALLAMPAAKGLFQKAIMESGAS RTMTKEQAASTSAAFLQVLGINEGQLDKLHTVSAEDLLKAADQLRIAEKENIFQLFFQ PALDPKTLPEEPEKAIAEGAASGIPLLIGTTRDEGYLFFTPDSDVHSQETLDAALEYL LGKPLAEKVADLYPRSLESQIHMMTDLLFWRPAVAYASAQSHYAPVWMYRFDWHPKKP PYNKAFHALELPFVFGNLDGLERMAKAEITDEVKQLSHTIQSAWITFAKTGNPSTEAV NWPAYHEETRETLILDSEITIENDPESEKRQKLFPSKGE*" /label="pnbA CDS" gene 3014949..3016418 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /label="pnbA gene" downshifts 3016395 /Source="Nicolas_upshifts" /id="D1780" /incds=0 /nref=4 /ntot=150 /MaxReadThrough="3.66738" /MaxDrop="2.70933" /score="-9.70074934" /energy="-12.2" /TU="U2703" /idTUdmin="U2703" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS 3016421..3016612 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514003.1" /translation="MGKTGYIGAAIVVAACIIILSAVVCLRDTVYYQPMRWTGIILFF AGIVMVPAYSAKRKPGKEK*" /label="hypothetical protein CDS" gene 3016421..3016612 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /label="gene" downshifts 3016591 /Source="Nicolas_upshifts" /id="D1781" /incds=0 /nref=24 /ntot=181 /MaxReadThrough="-0.096" /MaxDrop="4.20686" /score="34.8993337" /energy="-22.3" /TU="NA" /idTUdmin="U2703" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(3016639..3017124) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /EC_number="4.1.1.102" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9546183, 12903944, 17295427, 18326577, 21685295, 26658822" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9546183, 12903944, 17295427, 18326577, 21685295, 26658822; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase" /protein_id="NP_391320.1" /db_xref="EnsemblGenomes-Gn:BSU34400" /db_xref="EnsemblGenomes-Tr:CAB15445" /db_xref="GOA:O07006" /db_xref="InterPro:IPR008729" /db_xref="InterPro:IPR012674" /db_xref="PDB:2P8G" /db_xref="PDB:4ALB" /db_xref="SubtiList:BG12433" /db_xref="UniProtKB/Swiss-Prot:O07006" /translation="MENFIGSHMIYTYENGWEYEIYIKNDHTIDYRIHSGMVAGRWVR DQEVNIVKLTEGVYKVSWTEPTGTDVSLNFMPNEKRMHGIIFFPKWVHEHPEITVCYQ NDHIDLMKESREKYETYPKYVVPEFAEITFLKNEGVDNEEVISKAPYEGMTDDIRAGR L*" /label="padC CDS" gene complement(3016639..3017124) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /label="padC gene" CDS complement(3017147..3017458) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="EnsemblGenomes-Gn:BSU34410" /db_xref="EnsemblGenomes-Tr:CAB15446" /db_xref="GOA:O07005" /db_xref="InterPro:IPR011250" /db_xref="InterPro:IPR020915" /db_xref="PSEUDO:CAB15446.2" /db_xref="SubtiList:BG12432" /db_xref="UniProtKB/Swiss-Prot:O07005" /translation="MPGGADSQMIRANGRTDLSARYVIETADHELIYIENNGIRQVSK PFRKQAAAGEIIEPEHVYFRTVPTFETGSEVYQWLHDRLFIGSAERTPDYVLLDIYEV Q*" /label="yveG CDS" gene complement(3017147..3017458) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /pseudo /label="yveG gene" CDS complement(3017510..3017602) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU34420" /db_xref="EnsemblGenomes-Tr:CAB15447" /db_xref="PSEUDO:CAB15447.1" /db_xref="SubtiList:BG12431" /db_xref="UniProtKB/Swiss-Prot:O07004" /translation="MKKPVLKPFASLEIKVDPPITIGETSLGLR*" /label="yveF CDS" gene complement(3017510..3017602) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /pseudo /label="yveF gene" promotor_-10 complement(3017642..3017661) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3017659) /Source="Nicolas_upshifts" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3017675..3017682) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3017733..3018416) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /EC_number="5.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9987136, 19063962, 2054383, 28894939" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 19063962, 2054383, 28894939; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aminoacid racemase (prefers arginine, lysine and ornithine)" /protein_id="NP_391323.1" /db_xref="EnsemblGenomes-Gn:BSU34430" /db_xref="EnsemblGenomes-Tr:CAB15448" /db_xref="GOA:P32960" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004380" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="SubtiList:BG10391" /db_xref="UniProtKB/Swiss-Prot:P32960" /translation="MIGILAGMGPKSTSPFIDKVIDYCQKLYGASNDIDYPHMMIYSC PTPFYADRPIDHDEMKKAIIDGAVKLEKTGVDFIALPCNTAHVYYEEIQQALSVPMLH IVEETIKEIPHPAKKAVVLGTEPTIQSAIYQKVLKGNGQEVIHKDHWQQAVNQLIAAI KQPNHMQHTQALWQTLYEEISQHADIIISACTDLNAVLDHIQSEIPIIDSSACLAKST VSTYLAYQS*" /label="racX CDS" gene complement(3017733..3018416) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /label="racX gene" downshifts complement(3017751) /Source="Nicolas_upshifts" /id="D1782" /incds=0 /nref=122 /ntot=223 /MaxReadThrough="3.49026" /MaxDrop="5.32077" /score="5.15607483" /energy="-9.3" /TU="U2705" /idTUdmin="U2704" /TUdmin="-708" /isTUend="FALSE" /label="downshifts" CDS complement(3018432..3019787) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7592498, 9987136, 12533473, 14679248, 19063962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592498, 9987136, 12533473, 14679248, 19063962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4*" /protein_id="NP_391324.1" /db_xref="EnsemblGenomes-Gn:BSU34440" /db_xref="EnsemblGenomes-Tr:CAB15449" /db_xref="GOA:P32959" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR021860" /db_xref="SubtiList:BG10390" /db_xref="UniProtKB/Swiss-Prot:P32959" /translation="MKQNKRKHLQTLFETLGEKHQFNGTVLAAEGGDILYHHSFGYAE MTEKRPLKTNSLFELASLSKPFTALGIILLEEKGILGYEDKVDRWLPGFPYQGVTIRH LLNHTSGLPDYMGWFFANWDSHKIAVNQDIVDMLMNEGLSGYFEPNEGWMYSNTGYVL LAVIIEKASGMSYADFIKTSIFLPAGMNETRVYNRRLSPERIDHYAYGYVYDVHSETY VLPDELEETNYVVYLDGIQGDGTVNSVTSDLFRFDQALYQDDFISKASKESAFSPVRL NNGETIDYGFGWVLQNSPEKGRIVSHSGGWPGYSTMMIRYIDHRKTLIYLSNKEEDTE YEQAILKAAEHILFGQPYDVPERPADKKKKAIDTAIYSRYVGSYLLQDGTAAQVTTEN ERLYLEIAGQLRLELFPSSETRFFLRALSVEVEFTLGEDAAKSFILYEDGSEEEAVRT K*" /label="pbpE CDS" gene complement(3018432..3019787) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /label="pbpE gene" promotor_-10 complement(3019799..3019814) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3019815) /Source="Nicolas_upshifts" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3019826..3019835) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3020089..3020096 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3020110..3020129 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3020113 /Source="Nicolas_upshifts" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="upshifts" S_feature 3020135..3020325 /Source="Nicolas_S_feature" /locus_tag="new_3535821_3536011" /HighExp="G150, G180, G135, LBGexp, Mt0, Lbexp, LBGtran, dia0, GM 150, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.219024" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1314" CDS 3020326..3021747 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /EC_number="2.4.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levansucrase; levanase (moonlighting)" /protein_id="NP_391325.1" /db_xref="EnsemblGenomes-Gn:BSU34450" /db_xref="EnsemblGenomes-Tr:CAB15450" /db_xref="GOA:P05655" /db_xref="InterPro:IPR003469" /db_xref="InterPro:IPR023296" /db_xref="PDB:1OYG" /db_xref="PDB:1PT2" /db_xref="PDB:2VDT" /db_xref="PDB:3BYJ" /db_xref="PDB:3BYK" /db_xref="PDB:3BYL" /db_xref="PDB:3BYN" /db_xref="SubtiList:BG10388" /db_xref="UniProtKB/Swiss-Prot:P05655" /translation="MNIKKFAKQATVLTFTTALLAGGATQAFAKETNQKPYKETYGIS HITRHDMLQIPEQQKNEKYQVPEFDSSTIKNISSAKGLDVWDSWPLQNADGTVANYHG YHIVFALAGDPKNADDTSIYMFYQKVGETSIDSWKNAGRVFKDSDKFDANDSILKDQT QEWSGSATFTSDGKIRLFYTDFSGKHYGKQTLTTAQVNVSASDSSLNINGVEDYKSIF DGDGKTYQNVQQFIDEGNYSSGDNHTLRDPHYVEDKGHKYLVFEANTGTEDGYQGEES LFNKAYYGKSTSFFRQESQKLLQSDKKRTAELANGALGMIELNDDYTLKKVMKPLIAS NTVTDEIERANVFKMNGKWYLFTDSRGSKMTIDGITSNDIYMLGYVSNSLTGPYKPLN KTGLVLKMDLDPNDVTFTYSHFAVPQAKGNNVVITSYMTNRGFYADKQSTFAPSFLLN IKGKKTSVVKDSILEQGQLTVNK*" /label="sacB CDS" gene 3020326..3021747 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /label="sacB gene" downshifts 3021741 /Source="Nicolas_upshifts" /id="D1783" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.33324" /MaxDrop="3.39023" /score="9.57663013" /energy="-7.7" /TU="NA" /idTUdmin="U2706" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3021821..3023371 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /EC_number="3.2.1.64" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11739774, 15528654, 26773563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11739774, 15528654, 26773563; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endolevanase, selectively cleaves the (beta-2,6)fructosyl bonds" /protein_id="NP_391326.1" /db_xref="EnsemblGenomes-Gn:BSU34460" /db_xref="EnsemblGenomes-Tr:CAB15451" /db_xref="GOA:O07003" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG12430" /db_xref="UniProtKB/Swiss-Prot:O07003" /translation="MNYIKAGKWLTVFLTFLGILLFIDLFPKEEHDQKTKSKQKPDYR AAYHFTTPDKWKNDPQKPIYFDGKYHYFYLYNRDYPKGNGTEWRHAVSEDLVHWTDEG VAIPKYTNPDGDIWTGSVVVDKENTAGFGKNALVAIVTQPSAKDKKQEQYLWYSTDKG KSFKFYSGNPVMPNPGTDDFRDPKVIWDDQDNKWVMVMAEGSKIGFYESDNLKDWHYT SGFFPEQAGMVECPDLYMMRASDGTNKWVLGASANGKPWGKPNTYAYWTGSFDGKEFK ADQTEAQWLDYGFDWYGGVTFEDSKSTDPLEKRYALAWMNNWDYANNTPTMKNGFNGT DSVIRELRLKEQDGTYSLVSQPIEALEQLTVSTDEIEDQDVNGSKTLSITGDTYQLDT DLSWSELKNAGVRLRESEDQKRHIDVGIFAEGGYAYVNRAATNQPDKSNTYVESKAPY DVNKRKVHLKILVDKTTIEVFVGDGKTVFSNEVFPKPEDKGITLYSDGGTASFKNITV KHFDSIHE*" /label="levB CDS" gene 3021821..3023371 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /label="levB gene" promotor_-35 3023415..3023421 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3023435..3023446 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3023435 /Source="Nicolas_upshifts" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="upshifts" CDS 3023479..3025041 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12730183, 15528654, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12730183, 15528654, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-aspartate/L-glutamate / proton permease" /protein_id="NP_391327.1" /db_xref="EnsemblGenomes-Gn:BSU34470" /db_xref="EnsemblGenomes-Tr:CAB15452" /db_xref="GOA:O07002" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12429" /db_xref="UniProtKB/Swiss-Prot:O07002" /translation="MSKQGNFQKSMSLFDLILIGMGAIFGSAWLFAVSNVASKAGPSG AFSWILGGAIILLIGLVYAELGAALPRTGGIIRYPVYSHGHLVGYLISFVTIVAYTSL ISIEVTAVRQYVAYWFPGLTIKGSDSPTISGWILQFALLCLFFLLNYWSVKTFAKANF IISIFKYIVPITIIIVLIFHFQPENLSVQGFAPFGFTGIQAAISTGGVMFAYLGLHPI VSVAGEVQNPKRNIPIALIICIIVSTIIYTVLQVTFIGAIPTETLKHGWPAIGREFSL PFKDIAVMLGLGWLATLVILDAILSPGGNGNIFMNTTSRLVYAWARNGTLFGIFSKVN KDTGTPRASLWLSFALSIFWTLPFPSWNALVNVCSVALILSYAIAPISSAALRVNAKD LNRPFYLKGMSIIGPLSFIFTAFIVYWSGWKTVSWLLGSQLVMFLIYLCFSKYTPKED VSLAQQLKSAWWLIGFYIMMLIFSYIGSFGHGLGIISNPVDLILVAIGSLAIYYWAKY TGLPKAAIDYDK*" /label="aspP CDS" gene 3023479..3025041 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /label="aspP gene" downshifts 3025019 /Source="Nicolas_upshifts" /id="D1784" /incds=0 /nref=12 /ntot=29 /MaxReadThrough="1.71122" /MaxDrop="3.47798" /score="-0.444529447" /energy="-11.7" /TU="NA" /idTUdmin="U2707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3025031..3025720 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391328.2" /db_xref="EnsemblGenomes-Gn:BSU34480" /db_xref="EnsemblGenomes-Tr:CAB15453" /db_xref="GOA:O07001" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:2F07" /db_xref="SubtiList:BG12428" /db_xref="UniProtKB/Swiss-Prot:O07001" /translation="MINKEARGFLASLFFTNKHTRDKMNESQSLLEVFLMPKQTSGKY EKILQAAIEVISEKGLDKASISDIVKKAGTAQGTFYLYFSSKNALIPAIAENLLTHTL DQIKGRLHGDEDFWTVLDILIDETFLITERHKDIIVLCYSGLAIDHSMEKWETIYQPY YSWLEKIINKAIANHEVTEGINSKWTARTIINLVENTAERFYIGFEQDENVEVYKKEI FTFLKRSLGTA*" /label="yvdT CDS" gene 3025031..3025720 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /label="yvdT gene" promotor_-35 3025070..3025077 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3025091..3025110 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3025100 /Source="Nicolas_upshifts" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="upshifts" downshifts 3025701 /Source="Nicolas_upshifts" /id="D1785" /incds=0 /nref=189 /ntot=242 /MaxReadThrough="4.85194" /MaxDrop="4.84113" /score="-0.444529447" /energy="-11.7" /TU="U2708" /idTUdmin="U2707" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(3025799) /Source="Nicolas_upshifts" /id="D1786" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="0.8852" /MaxDrop="3.45447" /score="0.398849185" /energy="-11.7" /TU="NA" /idTUdmin="U2709" /TUdmin=704 /isTUend="FALSE" /label="downshifts" CDS 3025802..3026137 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22978536; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium / proton antiporter subunit A" /protein_id="NP_391329.1" /db_xref="EnsemblGenomes-Gn:BSU34490" /db_xref="EnsemblGenomes-Tr:CAB15454" /db_xref="GOA:O32262" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12427" /db_xref="UniProtKB/Swiss-Prot:O32262" /translation="MNWVLVFIAGLLEVVWASSLKHADSLLDWIIIFILIAVSFILLI RSYQKIPMAAAYTVFVGIGTVGTYLTGIVLGESFSAAQMFFLALLLAGILGMKLFTKE SKSQPGGEK*" /label="psmA CDS" gene 3025802..3026137 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /label="psmA gene" CDS 3026137..3026457 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11160890, 22978536; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium-proton two component antiporter subunit" /protein_id="NP_391330.1" /db_xref="EnsemblGenomes-Gn:BSU34500" /db_xref="EnsemblGenomes-Tr:CAB15455" /db_xref="GOA:O06999" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12426" /db_xref="UniProtKB/Swiss-Prot:O06999" /translation="MAWFLLVIAGIEEIIAAIAMKYIDGTRKKWPIIVMTVGFGLSFY CLSQAMIVLPAGVAYAVWTGIGSIGVSAVGLIWFKERFQLSQVISLCLILAGVIGLRL TSSS*" /label="psmB CDS" gene 3026137..3026457 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /label="psmB gene" S_feature 3026458..3026648 /Source="Nicolas_S_feature" /locus_tag="new_3542144_3542334" /HighExp="Sw, BC, BI, Lbstat, M0t90, Lbtran, M40t90, H2O2, S8, Paraq" /AntisenseName="yvdQ" /AntisenseCor="3.5547360410813897E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1315" CDS complement(3026493..3027005) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391331.1" /db_xref="EnsemblGenomes-Gn:BSU34510" /db_xref="EnsemblGenomes-Tr:CAB15456" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR021617" /db_xref="SubtiList:BG12425" /db_xref="UniProtKB/Swiss-Prot:O06998" /translation="MGILSGNPQDEPMHYGEVFGLWSYVMAGNKMVGNYQMLLNHVGD DDLKKLLRESIEKCQDEIKQVSTILKENGVALPPASPEPPTADLNDIPPGARFLDPDV AASAAAENAAGLVTCSKMMGQSIREDIAMMFGQFHMSKAATGAKYLRLLKNKGWLIPP PLHLQKHHEA*" /label="yvdQ CDS" gene complement(3026493..3027005) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /label="yvdQ gene" downshifts 3026625 /Source="Nicolas_upshifts" /id="D1787" /incds=1 /nref=6 /ntot=39 /MaxReadThrough="1.61612" /MaxDrop="4.65362" /score="0.608596632" /energy="-14.2" /TU="NA" /idTUdmin="U2708" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3027041..3027052) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3027047) /Source="Nicolas_upshifts" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3027067..3027073) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3027120..3027256) /Source="Nicolas_S_feature" /locus_tag="new_3542806_3542942_c" /HighExp="BT, S7, S8, S6, B36, G/S, S5, Pyr, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1316" downshifts complement(3027163) /Source="Nicolas_upshifts" /id="D1788" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.38169" /MaxDrop="2.9968" /score="15.2862513" /energy="-10.3" /TU="U2710" /idTUdmin="U2709" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" CDS complement(3027257..3028600) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /EC_number="1.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat protein; putative oxidoreductase" /protein_id="NP_391332.1" /db_xref="EnsemblGenomes-Gn:BSU34520" /db_xref="EnsemblGenomes-Tr:CAB15457" /db_xref="GOA:O06997" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12424" /db_xref="UniProtKB/Swiss-Prot:O06997" /translation="MGSTQLTGRVIFKGDPGYTEAIKNWNPYVDVYPLVFVFAQNSYD VSNAIKWARENKVPLRVRSGRHALDKNLSVVSGGIVIDVSDMNKVFLDEENAIATVQT GIPVGPLVKGLARDGFMAPFGDSPTVGIGGITMGGGFGVLSRSIGLISDNLLALKTVD AKGRIIHADQSHNEDLLWASRGGGGGNFGYNTQYTFKVHRAPKTATVFNIIWPWEQLE TVFKAWQKWAPFVDERLGCYLEIYSKINGLCHAEGIFLGSKTELIRLLKPLLHAGTPT EADIKTLYYPDAIDFLDPDEPIPGRNDQSVKFSSAWGHDFWSDEPISIMRKFLEDATG TEANFFFINWGGAISRVPKDETAFFWRHPLFYTEWTASWKNKSQEDSNLASVERVRQL MQPYVAGSYVNVPDQNIENFGKEYYGANFARLREIKAKYDPENVFRFPQSIPPSR*" /label="cotNP CDS" gene complement(3027257..3028600) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /label="cotNP gene" promotor_-10 complement(3028629..3028648) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3028637) /Source="Nicolas_upshifts" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3028661..3028670) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3028662..3028667 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3028683..3028701 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3028686 /Source="Nicolas_upshifts" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3028895..3028904 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3028913 /Source="Nicolas_upshifts" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3028918..3028937 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3028956..3029918 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 20378985" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 20378985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat lipolytic enzyme" /protein_id="NP_391333.1" /db_xref="EnsemblGenomes-Gn:BSU34530" /db_xref="EnsemblGenomes-Tr:CAB15458" /db_xref="GOA:O06996" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG12423" /db_xref="UniProtKB/Swiss-Prot:O06996" /translation="MAKYRIMTFDGGGTLGALSLQLLNRLARQNPKLISRTHVFSGNS IGSFTALALASGRSPRETLQYFEDEILPAFSISRPGGPVFNQQLPYSGFIKAVRNFFP ADLQLIDLRKRIVVPSFKLYSQKLDRWTPVLFHNFPGSPYLNEKVSDVILRSSGAPAT QRAYQNYVDGYVVATNPSTASIAFAVGKANVPLDQIAVLSIGTGEAPTRLRRDTRGWG MVSADNIRPENLKNLPPNWGVLLDRSPNEPLLPFLQMIAGGNGYYESMVSANLLGDRF FRLDPRIPNFSKTDPAVVPAVIEIANKTNLQPANQFIEKNWGSK*" /label="cotR CDS" gene 3028956..3029918 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /label="cotR gene" S_feature 3029919..3030172 /Source="Nicolas_S_feature" /locus_tag="new_3545605_3545858" /HighExp="BT, S8, S7, B36, S6, Pyr, G/S, S3, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1317" downshifts complement(3030199) /Source="Nicolas_upshifts" /id="D1789" /incds=0 /nref=190 /ntot=241 /MaxReadThrough="3.19421" /MaxDrop="5.60739" /score="16.7489574" /energy="-13.2" /TU="U2713" /idTUdmin="U2713" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" tRNA complement(3030203..3030278) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA (CCG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnQ-Arg tRNA" gene complement(3030203..3030278) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /label="trnQ-Arg gene" promotor_-10 complement(3030305..3030324) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3030326) /Source="Nicolas_upshifts" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3030340..3030343) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3030409..3030415 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3030425..3030500 /Source="Nicolas_S_feature" /locus_tag="new_3546111_3546186" /HighExp="Salt, S3, S4, Etha, S5, LoTm, Gly, M9-stat, BT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1318" upshifts 3030425 /Source="Nicolas_upshifts" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3030430..3030449 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3030477..3030484 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3030498..3030517 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3030502 /Source="Nicolas_upshifts" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="upshifts" CDS 3030548..3031141 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /EC_number="3.4.21.92" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease proteolytic subunit; Maxwell's demon" /protein_id="NP_391334.1" /db_xref="EnsemblGenomes-Gn:BSU34540" /db_xref="EnsemblGenomes-Tr:CAB15459" /db_xref="GOA:P80244" /db_xref="InterPro:IPR001907" /db_xref="InterPro:IPR018215" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR033135" /db_xref="PDB:3KTG" /db_xref="PDB:3KTH" /db_xref="PDB:3KTI" /db_xref="PDB:3KTJ" /db_xref="PDB:3KTK" /db_xref="PDB:3TT6" /db_xref="PDB:3TT7" /db_xref="SubtiList:BG19016" /db_xref="UniProtKB/Swiss-Prot:P80244" /translation="MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSAIDDNVANSI VSQLLFLAAEDPEKEISLYINSPGGSITAGMAIYDTMQFIKPKVSTICIGMAASMGAF LLAAGEKGKRYALPNSEVMIHQPLGGAQGQATEIEIAAKRILLLRDKLNKVLAERTGQ PLEVIERDTDRDNFKSAEEALEYGLIDKILTHTEDKK*" /label="clpP CDS" gene 3030548..3031141 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /label="clpP gene" downshifts 3031130 /Source="Nicolas_upshifts" /id="D1790" /incds=0 /nref=292 /ntot=300 /MaxReadThrough="4.45406" /MaxDrop="8.24306" /score="30.2626808" /energy="-14.6" /TU="U2714" /idTUdmin="U2715" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" S_feature 3031175..3031573 /Source="Nicolas_S_feature" /locus_tag="new_3546861_3547259" /HighExp="Etha, dia15, Heat, LoTm, M9-stat, Gly, dia5, Diami, S8, H2O2" /AntisenseName="pgcM" /AntisenseCor="0.13310786898312499" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1319" CDS complement(3031187..3031867) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /EC_number="2.7.1.41" /EC_number="5.4.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 11081794, 15996095" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 11081794, 15996095; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional beta-phosphoglucomutase / glucose-1-phosphate phosphodismutase" /protein_id="NP_391335.1" /db_xref="EnsemblGenomes-Gn:BSU34550" /db_xref="EnsemblGenomes-Tr:CAB15460" /db_xref="GOA:O06995" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR010972" /db_xref="InterPro:IPR010976" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3NAS" /db_xref="SubtiList:BG12422" /db_xref="UniProtKB/Swiss-Prot:O06995" /translation="MKAVIFDLDGVITDTAEYHFLAWKHIAEQIDIPFDRDMNERLKG ISREESLESILIFGGAETKYTNAEKQELMHRKNRDYQMLISKLTPEDLLPGIGRLLCQ LKNENIKIGLASSSRNAPKILRRLAIIDDFHAIVDPTTLAKGKPDPDIFLTAAAMLDV SPADCAAIEDAEAGISAIKSAGMFAVGVGQGQPMLGADLVVRQTSDLTLELLHEEWEQ YRIRESIP*" /label="mdxM CDS" gene complement(3031187..3031867) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /label="mdxM gene" downshifts complement(3031211) /Source="Nicolas_upshifts" /id="D1791" /incds=0 /nref=2 /ntot=36 /MaxReadThrough="3.4944" /MaxDrop="3.50516" /score="-9.43329271" /energy="-14.6" /TU="U2718" /idTUdmin="U2718" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" CDS complement(3031864..3033549) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9573215, 10229946, 1670768" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573215, 10229946, 1670768; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligo-1,4-1,6-alpha-glucosidase (sucrase-maltase-isomaltase)" /protein_id="NP_391336.1" /db_xref="EnsemblGenomes-Gn:BSU34560" /db_xref="EnsemblGenomes-Tr:CAB15461" /db_xref="GOA:O06994" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="PDB:4M56" /db_xref="PDB:4M8U" /db_xref="PDB:4MAZ" /db_xref="PDB:4MB1" /db_xref="SubtiList:BG12421" /db_xref="UniProtKB/Swiss-Prot:O06994" /translation="MSEWWKEAVVYQIYPRSFYDANGDGFGDLQGVIQKLDYIKNLGA DVIWLSPVFDSPQDDNGYDISDYKNMYEKFGTNEDMFQLIDEVHKRGMKIVMDLVVNH TSDEHAWFAESRKSKDNPYRDYYLWKDPKPDGSEPNNWGSIFSGSAWTYDEGTGQYYL HYFSKKQPDLNWENEAVRREVYDVMRFWMDRGVDGWRMDVIGSISKYTDFPDYETDHS RSYIVGRYHSNGPRLHEFIQEMNREVLSHYDCMTVGEANGSDIEEAKKYTDASRQELN MIFTFEHMDIDKEQNSPNGKWQIKPFDLIALKKTMTRWQTGLMNVGWNTLYFENHDQP RVISRWGNDRKLRKECAKAFATVLHGMKGTPFIYQGEEIGMVNSDMPLEMYDDLEIKN AYRELVVENKTMSEKEFVKAVMIKGRDHARTPMQWDAGKHAGFTAGDPWIPVNSRYQD INVKESLEDQDSIFFYYQKLIQLRKQYKIMIYGDYQLLQENDPQVFSYLREYRGEKLL VVVNLSEEKALFEAPPELIHERWKVLISNYPQERADLKSISLKPYEAVMGISI*" /label="mdxL CDS" gene complement(3031864..3033549) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /label="mdxL gene" CDS complement(3033542..3035815) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /EC_number="2.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16707683, 28527120" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 28527120; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose phosphorylase" /protein_id="NP_391337.1" /db_xref="EnsemblGenomes-Gn:BSU34570" /db_xref="EnsemblGenomes-Tr:CAB15462" /db_xref="GOA:O06993" /db_xref="InterPro:IPR005194" /db_xref="InterPro:IPR005195" /db_xref="InterPro:IPR005196" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR017045" /db_xref="SubtiList:BG12420" /db_xref="UniProtKB/Swiss-Prot:O06993" /translation="MINQRLFEIDEWKIKTNTFNKEHTRLLESLTSLANGYMGVRGNF EEGYSGDSHQGTYIAGVWFPDKTRVGWWKNGYPEYFGKVINAMNFMGIGLYVDGEKID LHQNPIELFEVELNMKEGILRRSAVVRIQDKTVRIRSERFLSLAVKELCAIHYEAECL TGDAVITLVPYLDGNVANEDSNYQEQFWQEEAKGADSHSGHLAAKTIENPFGTPRFTV LAAMANETEGFVHESFKTTEMYVENRYSYQTKASLKKFVIVTTSRDFREEELLSKAKE LLADVVENGYEDAKRRHTDRWKERWAKADIEIKGDEELQQGIRYNIFQLFSTYYGGDA RLNIGPKGFTGEKYGGAAYWDTEAYAVPMYLATAEPEVTKNLLLYRYHQLEAAKRNAA KLGMKGALYPMVTFTGDECHNEWEITFEEIHRNGAICYAIYNYINYTGDRNYMEEYGI DVLVAVSRFWADRVHFSKRKNKYMIHGVTGPNEYENNVNNNWYTNVIAAWTLEYTLQS LESISAEKRRHLDVQEVELEVWREIIQHMYYPFSEELQIFVQHDTFLDKDLQTVDELD PAERPLYQNWSWDKILRSNFIKQADVLQGIYLFNDRFTMEEKRRNFEFYEPMTVHESS LSPSVHAILAAELKLEKKALELYKRTARLDLDNYNHDTEEGLHITSMTGSWLAIVHGF AGMRTANETLSFAPFLPKEWDEYSFNINYRNRLINVTVDEKRVIFELVKGEPLHMNVY EEPVVLQGRCERRTPNE*" /label="mdxK CDS" gene complement(3033542..3035815) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /label="mdxK gene" CDS complement(3035793..3036677) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16707683, 16850406, 20436965; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative component of maltodextrin transporter" /protein_id="NP_391338.1" /db_xref="EnsemblGenomes-Gn:BSU34580" /db_xref="EnsemblGenomes-Tr:CAB15463" /db_xref="GOA:O06992" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG12419" /db_xref="UniProtKB/Swiss-Prot:O06992" /translation="MKNLENKSFIIRCLKAAASPSGVCRYGNTFSWLQLSFLFLFLTA CLMAPLAVSFVKMDRFSVSSFMPSAIQGVNDQFADQLQGFQIRNGKLTGGKSSERIED GQNVMAVDMKHEYETSGENGRLKVTGFENAIIFQPDQLVITDQNETGFSVGYAKMDVK LEKPNVHDVEVLIDTLWLAQYKPMIMMLAYTVVSMIQLLLTFVLAGGLWITKISNMVS IASFKEAASIAICASALPAFAAAAIGMVHFDLITVLMIHSCGVTLMISFAFRYLTKTR RDNGNLHSGGNDDKSAVI*" /label="mdxJ CDS" gene complement(3035793..3036677) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /label="mdxJ gene" CDS complement(3036683..3037519) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transporter (permease)" /protein_id="NP_391339.1" /db_xref="EnsemblGenomes-Gn:BSU34590" /db_xref="EnsemblGenomes-Tr:CAB15464" /db_xref="GOA:O06991" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12418" /db_xref="UniProtKB/Swiss-Prot:O06991" /translation="MNASTARMLNKICTYLFLTLLSIVIIYPLLITASSAFRVGNSAA FQLDFSGSWTLDHFKRLFDETLYLNWYSNTLVIALSVMVLQVTIVTLAGYSYSRYRFA GRKKSLIFFLIIQMVPTMAALTAFYVLAMLIGALDQYWFLTAIYIGGGIPMNTWLMKG YFDTVPREIDEAARIDGAGHLRIFASIVLPLVKPMLAVQALWAFMAPFGDYLLTKFLL RSPERLTIAVGLQSFISNPQQQKVALFAAGAILAALPICVLFFFLQKNFVSGLTAGGT KG*" /label="mdxG CDS" gene complement(3036683..3037519) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /label="mdxG gene" CDS complement(3037520..3038827) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transport system (permease)" /protein_id="NP_391340.1" /db_xref="EnsemblGenomes-Gn:BSU34600" /db_xref="EnsemblGenomes-Tr:CAB15465" /db_xref="GOA:O06990" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12417" /db_xref="UniProtKB/Swiss-Prot:O06990" /translation="MNKHHTLTKQKRKAGLLSIIPGLGQIANQQLSKGLLFLAITGLF AFELCVFGIQALTGLMTLGSVPGEDHSLFMLIEGTLQLIVTMIFLMFYIFNIHDSRKT AAMKAAGLEVNTTAKDMICHAGDKGFPYLFTLPAYIMMVFVIIFPVLVTLFVALTNYD FYHIPPNRLIDWVGFKNFLNIFFLGSYRETFVNVLGWTVIWTICATTLQIILGIVTAL FVNQDFIKGKRIFRMIFLFPWAVPAFITIMSFSNMFNDSIGAVNAQVIPLFNHLPFVE LPAIAWKTDPFWTKTALIMIQTWLGFPYIYVMVTGVLQAIPGELYEAAKIDGATFIQR FRHITFPMILFATAPVMITQYTFNFNNFSIIYLFNEGGPGSAGAGAGSTDILISWIYK LTTGTSPQYSVAAAVTLLISFIVIGISLIAFKKSNAFGNEEVM*" /label="mdxF CDS" gene complement(3037520..3038827) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /label="mdxF gene" promotor_-35 3037885..3037894 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3037907..3037926 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3037911 /Source="Nicolas_upshifts" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3038867..3040120) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="maltose/maltodextrin-binding lipoprotein" /protein_id="NP_391341.1" /db_xref="EnsemblGenomes-Gn:BSU34610" /db_xref="EnsemblGenomes-Tr:CAB15466" /db_xref="GOA:O06989" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12416" /db_xref="UniProtKB/Swiss-Prot:O06989" /translation="MVLLKKGFAILAASFLAIGLAACSSSKNPASSDGKKVLTVSVEE TYKEYIESIKTKFEKENDVTVKIVEKQMFEQLEALPLDGPAGNAPDVMLAAYDRIGGL GQQGHLLDIKPSNTKSFGDKEMQQVTVDGKVYGMPLVIETLILYYNKDLLKTAPKTFK DLEKLTEDPRFAFASEKGKSTGFLAKWTDFYMSYGLLAGYGGYVFGKNGTDSGDIGLN NKGAVEAVKYAEKWFETYWPKGMQDNSSADDFIQQMFLEGKAAAIIGGPWSAANYKEA KLNYGAAPIPTLPNGEEYAPFAGGKGWVASKYTKEPELAEKWLEYAANDANAYAFYED TNEVPANTAARKKADEQKNELTSAVIKQYETATPTPNIPEMAEVWTGAESLIFDAASG KKSTQTSANDAVNVIKENIKEKYVK*" /label="mdxE CDS" gene complement(3038867..3040120) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /label="mdxE gene" S_feature complement(3040121..3040215) /Source="Nicolas_S_feature" /locus_tag="new_3555807_3555901_c" /HighExp="T1.0H, T0.30H, BC, T1.30H, M40t90, M0t90, BI, B60, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.804" /TUlongSig="NA" /TUlongPSig="NA" /label="S1320" CDS complement(3040216..3041985) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10825545, 15650689, 16707683, 19465663, 27871383, 27871383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10825545, 15650689, 16707683, 19465663, 27871383, 27871383; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maltogenic alpha-amylase" /protein_id="NP_391342.1" /db_xref="EnsemblGenomes-Gn:BSU34620" /db_xref="EnsemblGenomes-Tr:CAB15467" /db_xref="GOA:O06988" /db_xref="InterPro:IPR004185" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013777" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12415" /db_xref="UniProtKB/Swiss-Prot:O06988" /translation="MMEYAAIHHQPFSTDAYSYDGRTVHIKIRTKKGDADHIRFIWGD PYEYNDGKWSANEQPMRKIAATEMHDYWFAEVVPPFRRLQYAFVVTDDHEDIFFGSSG VCPYNEKTLETIHYYFKFPFVHEADTFQAPEWVKSTVWYQIFPERFANGREDLSPKNA LPWGSKDPDVNDFFGGDLQGIVDKLDYLEDLGVNGIYLTPIFSAPSNHKYDTLDYFSI DPHFGDPELFRTLVSQLHQRGMRIMLDAVFNHIGSASPQWQDVVKNGDQSRYKDWFHI HSFPVTDDNYDRFAFTADMPKLNTANPEVQKYLLDIALYWIREFDIDGWRLDVANEVD HVFWKTFRQAVSTEKPDVYILGEIWHSAEPWLRGDEFHAAMNYPFTEPMIEYFADQTI SASRMAHRVNAHLMNGMKQANEVMFNLLDSHDTKRLLTRCRNDEKKARALLAFMFAQT GSPCIYYGTEIGLNGENDPLCRKCMVWEKEKQNQDMLQFMKRLIALRKQENTLLTEGH LEWNLLDDKNDFISFSRTLDEKILIYFFNQGNVVQHVSLRELNIDRNKKICDAWTEQP LQHHDVIAVQPGEFLILSAAAPV*" /label="mdxD CDS" gene complement(3040216..3041985) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /label="mdxD gene" promotor_-35 3041906..3041911 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3041927..3041945 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3041937 /Source="Nicolas_upshifts" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3042023..3042042) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3042036) /Source="Nicolas_upshifts" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3042055..3042062) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3042098..3043048) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16707683, 23951303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 23951303; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the maltodextrin operon (LacI family)" /protein_id="NP_391343.1" /db_xref="EnsemblGenomes-Gn:BSU34630" /db_xref="EnsemblGenomes-Tr:CAB15468" /db_xref="GOA:O06987" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12414" /db_xref="UniProtKB/Swiss-Prot:O06987" /translation="MATLSDVAKKANVSKMTVSRVINHPETVTDELKKLVHSAMKELN YIPNYAARALVQNRTQVVKLLILEEMDTTEPYYMNLLTGISRELDRNHYALQLVTRNS LNIGQCDGIIATGLRKNDFEGVIKAFEKPLVVFGQNEMGYDFIDVNNEKGTFMATRHV MGLGEREVVFFGIDLDEPFERAREQGYIRAMNKSFKKSNMFRIDNSSKKSECLARELL KSMDNQAAFVCASDRIALGVIRAAQSLGKRIPEDVAVTGNDGVFLDRISSPRLTTVRQ PVVEMGEACAKMLLKKMNEDGAAQGSLFFEPELIVRESTL*" /label="mdxR CDS" gene complement(3042098..3043048) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /label="mdxR gene" promotor_-10 complement(3043063..3043081) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3043076) /Source="Nicolas_upshifts" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3043093..3043101) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3043182) /Source="Nicolas_upshifts" /id="D1792" /incds=0 /nref=134 /ntot=243 /MaxReadThrough="0.22626" /MaxDrop="5.17193" /score="21.4455132" /energy="-10" /TU="NA" /idTUdmin="U2720" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(3043254..3043829) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391344.1" /db_xref="EnsemblGenomes-Gn:BSU34640" /db_xref="EnsemblGenomes-Tr:CAB15469" /db_xref="InterPro:IPR005269" /db_xref="InterPro:IPR031100" /db_xref="PDB:1T35" /db_xref="SubtiList:BG12413" /db_xref="UniProtKB/Swiss-Prot:O06986" /translation="MKTICVFAGSNPGGNEAYKRKAAELGVYMAEQGIGLVYGGSRVG LMGTIADAIMENGGTAIGVMPSGLFSGEVVHQNLTELIEVNGMHERKAKMSELADGFI SMPGGFGTYEELFEVLCWAQIGIHQKPIGLYNVNGYFEPMMKMVKYSIQEGFSNESHL KLIHSSSRPDELIEQMQNYSYPILEKKWTEI*" /label="yvdD CDS" gene complement(3043254..3043829) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /label="yvdD gene" downshifts complement(3043266) /Source="Nicolas_upshifts" /id="D1793" /incds=0 /nref=30 /ntot=209 /MaxReadThrough="4.23893" /MaxDrop="3.6086" /score="21.4455132" /energy="-10" /TU="U2720" /idTUdmin="U2720" /TUdmin="-87" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3043872..3043891) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3043878..3043885 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3043888) /Source="Nicolas_upshifts" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="upshifts" upshifts 3043895 /Source="Nicolas_upshifts" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3043898..3043917 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3043906..3043913) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3043946..3044266 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16120674, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrophosphohydrolase" /protein_id="NP_391345.1" /db_xref="EnsemblGenomes-Gn:BSU34650" /db_xref="EnsemblGenomes-Tr:CAB15470" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011411" /db_xref="SubtiList:BG12412" /db_xref="UniProtKB/Swiss-Prot:O32263" /translation="MQLADAEKWMKEFYEKRGWTEYGPFIRVGFLMEEAGELARAVRA YEIGRDRPDEKESSRAEQKQELIEEMGDVIGNIAILADMYGVSLEDVMKAHQEKLTKR FEHA*" /label="yvdC CDS" gene 3043946..3044266 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /label="yvdC gene" downshifts 3044247 /Source="Nicolas_upshifts" /id="D1794" /incds=0 /nref=134 /ntot=247 /MaxReadThrough="2.19085" /MaxDrop="5.46819" /score="35.8658106" /energy="-11.6" /TU="NA" /idTUdmin="U2721" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3044293) /Source="Nicolas_upshifts" /id="D1795" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="0.462300000000001" /MaxDrop="6.90114" /score="30.4681035" /energy="-11.3" /TU="NA" /idTUdmin="U2722" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(3044293..3045885) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion transporter" /protein_id="NP_391346.1" /db_xref="EnsemblGenomes-Gn:BSU34660" /db_xref="EnsemblGenomes-Tr:CAB15471" /db_xref="GOA:O06984" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12411" /db_xref="UniProtKB/Swiss-Prot:O06984" /translation="MRFSGRFKGYNLQKFQKDLIAGIVVGVVAIPLGMAFAIASGVEP EYGLYTVVIAGICISLFGGSKYQIGGPTGAFVPILFGIIMQYGLENLLIAGFMAGVML VLFGLFKLGKIMKFVPKPVIVGFTAGIAVLIFTEQIANFLGLRNVEKHENFHHNMFEI VQQLGTFNVYAILTAVIGLVILLVSAKVMPKVPGALLALLISTVVAVVFFPDRMATIG STYGEIPRHLPEFQFPELTLDKMVMLFPAALVIALLGGLESILSAMVADNMKGSKHDS NKELVGQGIANMAAPLFGGIPATGAIARTATNIKNGAVSPVSGVVHGVVVLLVLLVFA PYASHVPLASMAPILMVVAWNMSERKEVANMLRLKNADSFILAATFALTVLFDLIIGV ATGLLLAFVFFIRRMSEATRIHNQETHPVLAKREDPSVSMYAIEGPLFFGSIDSLESS LLEHVQKKPKTLILLMNKVHYMDTSAEAVLGNIMNRIKRHNGKLMIVGLQSQPKELLH KTGLFHKIGKQHFFDHHDEITG*" /label="yvdB CDS" gene complement(3044293..3045885) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /label="yvdB gene" CDS complement(3045904..3046497) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /EC_number="4.2.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10611359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carbonic anhydrase" /protein_id="NP_391347.1" /db_xref="EnsemblGenomes-Gn:BSU34670" /db_xref="EnsemblGenomes-Tr:CAB15472" /db_xref="GOA:O06983" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG12410" /db_xref="UniProtKB/Swiss-Prot:O06983" /translation="MNQMVSLTSILEHNQRFVSEKKYEPYKTTKFPSKKLVIVTCMDT RLTELLPQAMGLKNGDAKIVKNAGAIVSHPFGSVMRSILVAIYELQAEEVCIVGHHEC GMSGLNASSILEKAKERGVEDSCLNLLTSAGLDLKTWLTGFHSVEESVSHSVNMIKNH PLLPKKVPVHGLVIHPETGKLDVVINGYETELINNHS*" /label="yvdA CDS" gene complement(3045904..3046497) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /label="yvdA gene" promotor_-10 complement(3046539..3046558) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3046552) /Source="Nicolas_upshifts" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3046573..3046577) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3046623..3046628 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3046644..3046662 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3046645 /Source="Nicolas_upshifts" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3046818..3046825 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3046839..3046858 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3046843 /Source="Nicolas_upshifts" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="upshifts" CDS 3046880..3047857 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /EC_number="1.1.1.215" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811658, 25769838; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-ketogluconate reductase; hydroxypyruvate / glyoxylate reductase" /protein_id="NP_391348.1" /db_xref="EnsemblGenomes-Gn:BSU34680" /db_xref="EnsemblGenomes-Tr:CAB15473" /db_xref="GOA:O32264" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12409" /db_xref="UniProtKB/Swiss-Prot:O32264" /translation="MLKPFVFITKPIPEEIEAFIGEHCRYEVWQEDTLPSDVLFEKLK EAEGLLTSGTSGPSINRELLEHAPKLKVVSNQSVGYDNFDIEAMKERGVVGTHTPYTL DDTVADLAFSLILSSARRVAELDRFVRAGKWGTVEEEALFGIDVHHQTLGIIGMGRIG EQAARRAKFGFDMEVLYHNRHRKQETEDSIGVKYAELDTLLEQSDFILLITPLTDETY HMIGEREFKLMKNSAIFVNISRGKTVDEKALIRALQEGWIRGAGLDVYEKEPVTQDNP LLQLDNVTLLPHIGSATAKVRFNMCKQAAENMLAAIQGQTPKNLTREFQ*" /label="yvcT CDS" gene 3046880..3047857 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /label="yvcT gene" downshifts 3047829 /Source="Nicolas_upshifts" /id="D1796" /incds=0 /nref=223 /ntot=269 /MaxReadThrough="2.44036" /MaxDrop="5.93476" /score="1.05732532" /energy="-14.7" /TU="NA" /idTUdmin="U2724" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3047895..3049835) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (permease)" /protein_id="NP_391349.1" /db_xref="EnsemblGenomes-Gn:BSU34690" /db_xref="EnsemblGenomes-Tr:CAB15474" /db_xref="GOA:O06981" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG12408" /db_xref="UniProtKB/Swiss-Prot:O06981" /translation="MNLRTIARKNILGNLQRYVAYFLSCVFAVSVFFVFTSFIFHPDV NEDNIYGGSLVKTCLSAALVVIIVFCIFFITYSNSAFLQARKKEFGLLTLFGTSKQQL RKMIYYEQSLISLAAIAAGIGAGLLFSKLFFMIMTWMLSVKVPISFAIVPKAFVMTIA GFLILFQTLLILSLGRIRKLEIIELIKSAKKPKSLPVYSKWLTVLSLLCLGSGYYLSA TANAIDMMFRVFPILILVLIGTYFFFTQSSVAFFRMLYRKKHSFYKGTNIIVRSNMIF RLKDHARMLFLTSVITAVILTATGVIYMFYSDLQRQEEQSIPQSVSWVEKDASRFQVM KPETAENTLKKAHAVITYKVDATGIPVTFQSDLPYGNKKMEAEALLISEKVYNQVAKE KGFPVIHLQENEAFINVSFQMMVKDTFGEGETAAFHMKSGKTLSYVMKKQQNKGILMS VDGVSRLLVVSEKSFDSLSQDVPLKEQMRMVGYELEHWQETVDVSEKLENMVPKEHTS DFQTRAPSYQIVKQGVALMLFIGLFVSVLFFIVQGSMLYLRMFTEIEDTGVQVLALKR IGVTDKEIHSILGKQIGFLFFIPFIAGTIHAGFAYAALSNMLNSNLFLEAVIVIFIYF VFQALYYIVTRHIYKRAVLQRM*" /label="psdB CDS" gene complement(3047895..3049835) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /label="psdB gene" downshifts complement(3047919) /Source="Nicolas_upshifts" /id="D1797" /incds=0 /nref=11 /ntot=187 /MaxReadThrough="0.26118" /MaxDrop="4.59213" /score="26.9028733" /energy="-14.7" /TU="NA" /idTUdmin="U2725" /TUdmin=34 /isTUend="FALSE" /label="downshifts" CDS complement(3049810..3050589) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12432961, 14651641, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (ATP-binding protein)" /protein_id="NP_391350.1" /db_xref="EnsemblGenomes-Gn:BSU34700" /db_xref="EnsemblGenomes-Tr:CAB15475" /db_xref="GOA:O06980" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12407" /db_xref="UniProtKB/Swiss-Prot:O06980" /translation="MNVLQTTNLSKTYYSNKGTISYQALSAFDLSVSKGEFVGIMGPS GSGKTTLLNLLATIDKPTQGEMMINGIQPKTLKDQELALFRRRELGFVFQDFNLLDTL TIRENILLPLALDKVKLREMEARLDELADTLQIKHILDHRTYEVSGGQQQRAACARAI IHNPALILADEPTGNLDSKSAKQVMNTLAQLNEEKEATILLVTHDATAASFCKRIVFI KDGRFFSEIHRGTNRQVFYQSILDTLSVLGGDFHEFENYRP*" /label="psdA CDS" gene complement(3049810..3050589) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /label="psdA gene" S_feature complement(3050590..3050671) /Source="Nicolas_S_feature" /locus_tag="new_3566276_3566357_c" /HighExp="LBGtran, M0t45, H2O2, C30, Lbexp, Lbstat, LBGstat, dia0, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1321" CDS complement(3050672..3051742) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [PsdR] response to lantibiotics (nisin and gallidermin)" /protein_id="NP_391351.1" /db_xref="EnsemblGenomes-Gn:BSU34710" /db_xref="EnsemblGenomes-Tr:CAB15476" /db_xref="GOA:O06979" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12406" /db_xref="UniProtKB/Swiss-Prot:O06979" /translation="MLKTYLIDRLAIILFSLLGIGSAMLIAYLSIVESGAEPSKENMM YIWILPGTLLAAGFAADYVRQFSFLTYVKKLAEQASSSNDIGQSLKARKPRTGEQALW TKMINALGQQYESRLSQYINQQKQHYTFTNQWVHHMKTPVSVISLMIQEGKNGTSSSF PTFLEELEDENERFRHGLDMMLQTARLEEFAFDVKPQTFDLAEMVRSLINQEKRQFIK RRLFPTLHVPPNAVQISSDQKWLSFVVEQILFNALKYSKQGVGDPITIRIETQGHETR LSVADEGIGIPPQDLPRIFDAFFTGENGRTMKEATGMGLYLAKQVCSRLGHKLYAESK EGAGTVMTIVFSSDTLVNVTAL*" /label="psdS CDS" gene complement(3050672..3051742) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /label="psdS gene" CDS complement(3051736..3052449) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [PsdS] responding to lipid II-binding lantibiotics (nisin and gallidermin)" /protein_id="NP_391352.1" /db_xref="EnsemblGenomes-Gn:BSU34720" /db_xref="EnsemblGenomes-Tr:CAB15477" /db_xref="GOA:O06978" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12405" /db_xref="UniProtKB/Swiss-Prot:O06978" /translation="MYRILLVEDDERIASLLGGHLQKYGYEVKIAEQLNDIKLEFAEM KPDLVLLDINLPFFDGFYWCRQIRTISNAPIIFISARTDELNQVMAIENGGDDYITKP FHLEVVMAKIKSVLRRTYGEYSPSLPQESRIVELGGLTIYPDQNEAEWNSVRILFSQK EFQLLSIFVREHKKIVSRDELLEALWDDVDFVDDNTLTVNVNRLRRKLENAGLTDCIS TIRGQGYQFQVNRKDEAEC*" /label="psdR CDS" gene complement(3051736..3052449) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /label="psdR gene" promotor_-10 complement(3052495..3052514) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3052507) /Source="Nicolas_upshifts" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3052509..3052770) /Source="Nicolas_S_feature" /locus_tag="new_3568195_3568456_c" /HighExp="H2O2, G135, G180, Cold, Paraq, G150, dia15, Oxctl, LBGexp, C30" /AntisenseName="yvzJ" /AntisenseCor="0.56014644713727801" /AntisenseRegPval="-22.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1322" promotor_-35 complement(3052527..3052530) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3052530..3052537 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3052548..3052567 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3052553 /Source="Nicolas_upshifts" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="upshifts" CDS 3052596..3052805 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="YP_003097790.1" /db_xref="EnsemblGenomes-Gn:BSU34729" /db_xref="EnsemblGenomes-Tr:CAX52696" /db_xref="GOA:C0H3R7" /db_xref="UniProtKB/Swiss-Prot:C0H3R7" /translation="MKKIMLFLAMTSILSACQPNYTGKYIEIGDTLTDYTKECFKENE IPYKYEKGKLYIPEDAFDTAIYTCS*" /label="yvzJ CDS" gene 3052596..3052805 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /label="yvzJ gene" downshifts 3052783 /Source="Nicolas_upshifts" /id="D1798" /incds=0 /nref=7 /ntot=138 /MaxReadThrough="1.16039" /MaxDrop="3.61604" /score="-5.58790836" /energy="-11.4" /TU="NA" /idTUdmin="U2726" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3052815) /Source="Nicolas_upshifts" /id="D1799" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="3.16808" /MaxDrop="2.84175" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(3052841..3053605) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10876241; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative arylamine N-acetyltransferase" /protein_id="NP_391353.1" /db_xref="EnsemblGenomes-Gn:BSU34730" /db_xref="EnsemblGenomes-Tr:CAB15478" /db_xref="GOA:O06977" /db_xref="InterPro:IPR001447" /db_xref="SubtiList:BG12404" /db_xref="UniProtKB/Swiss-Prot:O06977" /translation="MIKMSDFLKDCFQKIGWEKDHVSFGDLPLFLKAMAYRFPFENRA VLAKENYKITKEELWRRLLKDQHGGLCYDLNGFLYFVLREAGFHVKLIRGTVYAGDQE GWALEGTHAAVWLSAENGDYLVDIGFGINLALQPIPLSGETVQSPVGSFRIKKEETEK GSYVLLMDKGEGWQIGYAFTLEESDLGDLDNMKDIIHSHEKSPFNKSLLASKLTPSGR MVMSERHFTIYENGGNIQKSDIGPSGFEEKLNTHFL*" /label="yvcN CDS" gene complement(3052841..3053605) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /label="yvcN gene" downshifts complement(3052863) /Source="Nicolas_upshifts" /id="D1800" /incds=0 /nref=143 /ntot=253 /MaxReadThrough="3.19848" /MaxDrop="6.45069" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3053606..3053863) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="catabolite repression HPr-like protein" /protein_id="NP_391354.1" /db_xref="EnsemblGenomes-Gn:BSU34740" /db_xref="EnsemblGenomes-Tr:CAB15479" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1K1C" /db_xref="PDB:1MO1" /db_xref="PDB:1MU4" /db_xref="PDB:1ZVV" /db_xref="PDB:2AK7" /db_xref="PDB:2RLZ" /db_xref="SubtiList:BG12403" /db_xref="UniProtKB/Swiss-Prot:O06976" /translation="MVQQKVEVRLKTGLQARPAALFVQEANRFTSDVFLEKDGKKVNA KSIMGLMSLAVSTGTEVTLIAQGEDEQEALEKLAAYVQEEV*" /label="crh CDS" gene complement(3053606..3053863) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /label="crh gene" CDS complement(3053887..3054837) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10986251, 17603302, 19836336, 24097947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative morphogen" /protein_id="NP_391355.1" /db_xref="EnsemblGenomes-Gn:BSU34750" /db_xref="EnsemblGenomes-Tr:CAB15480" /db_xref="GOA:O06975" /db_xref="InterPro:IPR003802" /db_xref="InterPro:IPR018478" /db_xref="InterPro:IPR023054" /db_xref="InterPro:IPR027434" /db_xref="InterPro:IPR033981" /db_xref="SubtiList:BG12402" /db_xref="UniProtKB/Swiss-Prot:O06975" /translation="MSFASETKKELTNLEVKDCCINAELSALIRMNGALSFTNRHLVL DVQTENAAIARRIYTLLKKQYDVSVELLVRKKMRLKKNNVYIVRFSENAKAILEDLKI LGENFVFERSISKELVKKRCCKRSYMRGAFLAGGSVNNPETSSYHLEIFSLYKEHNDS LCDLLNEFQLNSKTLERKKGYITYLKEAEKITEFLNVIGAHNSLLRFEDVRIVRDMRN SVNRLVNCETANLNKTIGASLRQVENIKYIDERIGLEALPEKLREIAQLRIDYQEVTL KELGEMVASGKISKSGINHRLRKLDEIAEQLRTGQTVTLK*" /label="whiA CDS" gene complement(3053887..3054837) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /label="whiA gene" CDS complement(3054860..3055813) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159; Product type f: factor" /codon_start=1 /transl_table=11 /product="gluconeogenesis morphogenetic factor (UDP-sugar binding)" /protein_id="NP_391356.2" /db_xref="EnsemblGenomes-Gn:BSU34760" /db_xref="EnsemblGenomes-Tr:CAB15481" /db_xref="GOA:O06974" /db_xref="InterPro:IPR002882" /db_xref="InterPro:IPR010119" /db_xref="SubtiList:BG12401" /db_xref="UniProtKB/Swiss-Prot:O06974" /translation="MGQKPKIAIFGGGTGLSVLLRGLKHKPVDITAIVTVADDGGSSG RLRNELKIPPPGDIRNVLAALSDVEPLVEDLFQHRFNKGNDLTGHSLGNLILAAMTNI TGDFFHAVTEMSKVLNVRGKVLPAANASVVLHAEMEDGRVVSGESTIPEYGQRIKRVF LTPEQIDPLPETIDVIREADLIIIGPGSLYTSILPNLLVPKIGEEVIKAPAKKVYICN VMTQPGETLHYTAADHVKALNQHMGCGFIDTILVNSEDIPDEIKRKYEMESARPVDFD IEELKAMGLEVIRDQIVTYKNDVIRHDTHKVASLLVDLLKE*" /label="mgfK CDS" gene complement(3054860..3055813) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /label="mgfK gene" CDS complement(3055815..3056702) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /function="15.6: DNA transformation" /experiment="publication(s) with functional evidences, PMID:18334534, 19074378, 21179021, 21709426" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18334534, 19074378, 21179021, 21709426; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase possibly involved in regulator sRNA degradation" /protein_id="NP_391357.1" /db_xref="EnsemblGenomes-Gn:BSU34770" /db_xref="EnsemblGenomes-Tr:CAB15482" /db_xref="GOA:O06973" /db_xref="InterPro:IPR005337" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12400" /db_xref="UniProtKB/Swiss-Prot:O06973" /translation="MSVSESHDIQLVIITGMSGAGKTVAIQSFEDLGYFCVDNLPPSL LPKFLELMKESNSKMSKVALVMDLRGREFFDRLIEALDEMAENPWITPRILFLDAKDS ILVTRYKETRRSHPLAATGLPLEGIALERELLEELKGRSQIIYDTSDMKPRDLREKIV KHFATNQGETFTVNVMSFGFKYGIPIDADLVFDVRFLPNPYYIESMRPLTGKDKEVSS YVMKWNETQKFNEKLIDLLSFMLPSYKREGKSQVVIAIGCTGGQHRSVTLAENLADYF KKDYYTHVTHRDIEKRSRK*" /label="yvcJ CDS" gene complement(3055815..3056702) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /label="yvcJ gene" CDS complement(3056727..3057203) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /EC_number="3.6.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative triphosphate pyrophosphate hydrolase" /protein_id="NP_391358.1" /db_xref="EnsemblGenomes-Gn:BSU34780" /db_xref="EnsemblGenomes-Tr:CAB15483" /db_xref="GOA:O06972" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG12399" /db_xref="UniProtKB/Swiss-Prot:O06972" /translation="MTYLQRVTNCVLQTDDKVLLLQKPRRGWWVAPGGKMESGESVRD SVIREYREETGIYIINPQLKGVFTFIIKDGDHIVSEWMMFTFVADSYTGQNVSESEEG KLQWHDVNDIQNLPMAPGDGHILDFMMKGQGLLHGTFTYTPEFELLSYRLDPQHIK*" /label="yvcI CDS" gene complement(3056727..3057203) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /label="yvcI gene" promotor_-10 complement(3057223..3057242) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3057237) /Source="Nicolas_upshifts" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3057258..3057262) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3057281..3057300) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3057294) /Source="Nicolas_upshifts" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3057315..3057318) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3057370..3057520) /Source="Nicolas_S_feature" /locus_tag="new_3573056_3573206_c" /HighExp="dia15, Diami, dia5, H2O2, Etha, LPhT, Cold, Paraq, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1323" downshifts complement(3057413) /Source="Nicolas_upshifts" /id="D1801" /incds=0 /nref=9 /ntot=78 /MaxReadThrough="6.94979" /MaxDrop="3.73811" /score="11.9453839" /energy="-11" /TU="U2729,U2733" /idTUdmin="U2734" /TUdmin=2904 /isTUend="FALSE" /label="downshifts" CDS complement(3057521..3058471) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /EC_number="1.8.1.9" /function="16.6: Maintain" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14597697, 15659166, 23813734, 24401092" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14597697, 15659166, 23813734, 24401092; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thioredoxin reductase" /protein_id="NP_391359.1" /db_xref="EnsemblGenomes-Gn:BSU34790" /db_xref="EnsemblGenomes-Tr:CAB15484" /db_xref="GOA:P80880" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR005982" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12398" /db_xref="UniProtKB/Swiss-Prot:P80880" /translation="MSEEKIYDVIIIGAGPAGMTAAVYTSRANLSTLMIERGIPGGQM ANTEDVENYPGFESILGPELSNKMFEHAKKFGAEYAYGDIKEVIDGKEYKVVKAGSKE YKARAVIIAAGAEYKKIGVPGEKELGGRGVSYCAVCDGAFFKGKELVVVGGGDSAVEE GVYLTRFASKVTIVHRRDKLRAQSILQARAFDNEKVDFLWNKTVKEIHEENGKVGNVT LVDTVTGEESEFKTDGVFIYIGMLPLSKPFENLGITNEEGYIETNDRMETKVEGIFAA GDIREKSLRQIVTATGDGSIAAQSVQHYVEELQETLKTLK*" /label="trxB CDS" gene complement(3057521..3058471) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /label="trxB gene" S_feature complement(3058472..3058559) /Source="Nicolas_S_feature" /locus_tag="new_3574158_3574245_c" /HighExp="dia5, Diami, dia15, H2O2, Etha, Salt, Cold, Paraq, LPhT, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1324" promotor_-10 complement(3058548..3058567) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3058559) /Source="Nicolas_upshifts" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3058561..3058652) /Source="Nicolas_S_feature" /locus_tag="new_3574247_3574338_c" /HighExp="Cold, Oxctl, G180, G135, Paraq, C30, LBGexp, G150, S1, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1325" promotor_-35 complement(3058582..3058585) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3058600..3058606 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3058620..3058638 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3058634 /Source="Nicolas_upshifts" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="upshifts" S_feature 3058635..3062021 /Source="Nicolas_S_feature" /locus_tag="new_3574321_3577707" /HighExp="Sw, M9-stat, B60, T0.30H, Gly, BC, B36, T1.0H, Salt, C30" /AntisenseName="yvcD" /AntisenseCor="-0.261780844003138" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1326" CDS complement(3058677..3060098) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /EC_number="3.4.-.-" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted cell wall DL-endopeptidase" /protein_id="NP_391360.1" /db_xref="EnsemblGenomes-Gn:BSU34800" /db_xref="EnsemblGenomes-Tr:CAB15485" /db_xref="GOA:P40767" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG11023" /db_xref="UniProtKB/Swiss-Prot:P40767" /translation="MRKSLITLGLASVIGTSSFLIPFTSKTASAETLDEKKQKIESKQ SEVASSIEAKEKELTELQENQSKIEKELKDINDKALDTSNKIEDKKEENDKTKEEIKK LKKEIKETEARIEKRNEILKKRVRSLQESGGSQGYIDVLLGSTSFGDFISRATAVSSI VDADKDLIKQQEQDKAKLEDSEADLNDKLKEVQAALAKLETMQKDLDKQLNEKDKLFD EAKASQKKTAKAISELKSEASELANQKANTEAEQARIKKEQEAAAALIKKQEEAQKAS DETQTDDSQTATTESSKASSSDDSSDNSSDNSSNGSSNSSSNGSSSKKSSGSNSNSGG TVISNSGGIEGAISVGSSIVGQSPYKFGGGRTQSDINNRIFDCSSFVRWAYASAGVNL GPVGGTTTDTLVGRGQAVSASEMKRGDLVFFDTYKTNGHVGIYLGNGTFLNDNTSHGV SVDSMSNPYWKAAFKGVVRRVVQ*" /label="cwlO CDS" gene complement(3058677..3060098) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /label="cwlO gene" downshifts complement(3058697) /Source="Nicolas_upshifts" /id="D1802" /incds=0 /nref=8 /ntot=106 /MaxReadThrough="6.31311" /MaxDrop="3.4602" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1620 /isTUend="FALSE" /label="downshifts" downshifts complement(3058821) /Source="Nicolas_upshifts" /id="D1803" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="7.07718" /MaxDrop="2.13349" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1496 /isTUend="FALSE" /label="downshifts" misc_feature 3059725..3059729 /Source="Nicolas_upshift_promotors" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3059735 /Source="Nicolas_upshifts" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3060014..3060018 /Source="Nicolas_upshift_promotors" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3060021 /Source="Nicolas_upshifts" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3060099..3060296) /Source="Nicolas_S_feature" /locus_tag="new_3575785_3575982_c" /HighExp="S1, Cold, T-3.40H, M9-exp, MG t5, MG 5, MG 15, T-5.40H, GM-0.2, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1327" downshifts 3060219 /Source="Nicolas_upshifts" /id="D1804" /incds=0 /nref=2 /ntot=119 /MaxReadThrough="6.41604" /MaxDrop="3.8522" /score="6.14322693" /energy="-7.6" /TU="U2730,U2731" /idTUdmin="U2731" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3060284..3060303) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-10" upshifts complement(3060296) /Source="Nicolas_upshifts" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="upshifts" promotor_-35 complement(3060315..3060322) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-35" CDS complement(3060479..3061933) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391361.1" /db_xref="EnsemblGenomes-Gn:BSU34810" /db_xref="EnsemblGenomes-Tr:CAB15486" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12396" /db_xref="UniProtKB/Swiss-Prot:O06968" /translation="MGKHTSEHKNHAQIVQLLQDGQYFFHKGLKAYKERNLKRASKLI QRAVHLEPEDSEMLSQLAVIYSEMGQYQESNDLLDYIMANLEAEMPECHYFKANNFAH LGLFQEAYKEAAAYSDADPDGEFAEENDSLLDLLDLGDDGIEDSLYDQDELLVKQDRA KSLLESGQLAEAVAALEEITTEYPELWSAYNNLALAYFYSGNVVKAKQTAYEVLSHNE GNLHALCNLLVFYYYEREDEKVAELSDQLSNVYPMLLEQRYKLGATLALVGRYEIGYK WLKSLYKTGFEGDDTFFYWLSCSAYFTGHTDFAETIWRKVESQYPGEDRPAPWIERRE ALPSSVEQRLAAYYISSTKGETEHLEAVIRSKRITAPFETHFVKLLLNGDSAAADVSE DALFAYQTVKLLEQAEKEEMKTEVMSCWVFHVIQQIRAAAPLKNEKGWAAAICYIWKE AHGKQDTKKDTAARFGISPATLTKYMKYIDDILE*" /label="yvcD CDS" gene complement(3060479..3061933) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /label="yvcD gene" downshifts complement(3060499) /Source="Nicolas_upshifts" /id="D1805" /incds=0 /nref=11 /ntot=190 /MaxReadThrough="3.36188" /MaxDrop="3.98985" /score="16.3455178" /energy="-9.1" /TU="U2734" /idTUdmin="U2734" /TUdmin="-182" /isTUend="FALSE" /label="downshifts" S_feature complement(3061934..3062058) /Source="Nicolas_S_feature" /locus_tag="new_3577620_3577744_c" /HighExp="LBGstat, Sw, Cold, BC, BI, Lbexp, dia0, G150, LBGtran, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1328" downshifts 3061979 /Source="Nicolas_upshifts" /id="D1806" /incds=0 /nref=4 /ntot=36 /MaxReadThrough="1.81602" /MaxDrop="3.41181" /score="7.59889121" /energy="-9.9" /TU="NA" /idTUdmin="U2730" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3062059..3063828) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16405427, 18215075, 21077936, 22711831, 24630999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16405427, 18215075, 21077936, 22711831, 24630999; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter (ATP-binding and permease protein)" /protein_id="NP_391362.1" /db_xref="EnsemblGenomes-Gn:BSU34820" /db_xref="EnsemblGenomes-Tr:CAB15487" /db_xref="GOA:O06967" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12395" /db_xref="UniProtKB/Swiss-Prot:O06967" /translation="MPTKKQKSKSKLKPFFALVRRTNPSYGKLAFALALSVVTTLVSL LIPLLTKQLVDGFSMSNLSGTQIGLIALVFFVQAGLSAYATYALNYNGQKIISGLREL LWKKLIKLPVSYFDTNASGETVSRVTNDTMVVKELITTHISGFITGIISVIGSLTILF IMNWKLTLLVLVVVPLAALILVPIGRKMFSISRETQDETARFTGLLNQILPEIRLVKA SNAEDVEYGRGKMGISSLFKLGVREAKVQSLVGPLISLVLMAALVAVIGYGGMQVSSG ELTAGALVAFILYLFQIIMPMGQITTFFTQLQKSIGATERMIEILAEEEEDTVTGKQI ENAHLPIQLDRVSFGYKPDQLILKEVSAVIEAGKVTAIVGPSGGGKTTLFKLLERFYS PTAGTIRLGDEPVDTYSLESWREHIGYVSQESPLMSGTIRENICYGLERDVTDAEIEK AAEMAYALNFIKELPNQFDTEVGERGIMLSGGQRQRIAIARALLRNPSILMLDEATSS LDSQSEKSVQQALEVLMEGRTTIVIAHRLSTVVDADQLLFVEKGEITGRGTHHELMAS HGLYRDFAEQQLKMNADLENKAG*" /label="bmrA CDS" gene complement(3062059..3063828) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /label="bmrA gene" S_feature complement(3063829..3063903) /Source="Nicolas_S_feature" /locus_tag="new_3579515_3579589_c" /HighExp="LBGstat, Cold, Lbexp, G150, Oxctl, dia0, T1.30H, T0.30H, BC, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1329" misc_feature complement(3063892..3063911) /Source="Nicolas_upshift_promotors" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3063903) /Source="Nicolas_upshifts" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="upshifts" CDS complement(3063993..3064352) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391363.1" /db_xref="EnsemblGenomes-Gn:BSU34830" /db_xref="EnsemblGenomes-Tr:CAB15488" /db_xref="SubtiList:BG14157" /db_xref="UniProtKB/Swiss-Prot:O32265" /translation="MTSLFSESETEIVSTTYMFLTQDEMKGKAGTLNQPINDFLSLTK KFESSLKEEIKGQKGLIVKKIKKELESNSEKRKAALQMIKEEHTAKVDRYKMIIEDLR QQDVTLTYRKKKPVKDV*" /label="yvzA CDS" gene complement(3063993..3064352) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /label="yvzA gene" downshifts complement(3064013) /Source="Nicolas_upshifts" /id="D1807" /incds=0 /nref=146 /ntot=246 /MaxReadThrough="2.52417" /MaxDrop="4.81771" /score="18.5636016" /energy="-13.2" /TU="NA" /idTUdmin="U2735" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3064367..3066277) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391364.1" /db_xref="EnsemblGenomes-Gn:BSU34840" /db_xref="EnsemblGenomes-Tr:CAB15489" /db_xref="SubtiList:BG12394" /db_xref="UniProtKB/Swiss-Prot:O06966" /translation="MGNKNVFENENVKLRLIDLEYDYKQKFASTIASEVKKAKKDFEA DIRRIYKEETHHDLPENMKIEIYTSNELVNQNTSIQSSTRESGYDGTAIHIIDEKKHI DQLQIISEGSADNKDWSYNFFGLFLGIDHSQYEATKEFTNKAKKAAGNSEDLKTFALG HSLANNNQVMVQLIDGEYDEVYGVNGAQVNIDQLLETDESLYRYVIRKFSYKYEDIDS IPPEKLKKEIQKYYEDKGVTTNITQRISKDDPLYGVSGKADFITFGDVKMADTNTSVK GIRNIMDGVPDEDVRSIQKFLQKYKDDYEKDGLNGFIKAASGIDIDLIEKVKNTDGAL KKVSVLYEHFDDVKQMYGRIKEELPSFLGFLHTLLRNSGPVVDQLAENGYIDETQKKV IKKELTNINASMRGIESRYEHFIDHLKHGQFMQALKDVGEIVDYVKSILSSLKTLDTE TKDALKLIVDGHSIVQMLNALSKEKGFSYKGSDIYFTGKSGSGETIQVNLSSAVRIYQ NGMKIVEDMEDAISKYQKVYSQEIDEDFIDKKQAIITAIHHMEENPSHYAFDLQFRLA AGFSHTFDKLEKISVHESFHTGALPANDGIVAELKKQTTEKRDFIKNIRESIEKLFEK EEMISQLFDFQS*" /label="yvcB CDS" gene complement(3064367..3066277) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /label="yvcB gene" CDS complement(3066279..3067004) /gene="yvcA" /locus_tag="BSU_34850" /old_locus_tag="BSU34850" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17590234; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391365.1" /db_xref="EnsemblGenomes-Gn:BSU34850" /db_xref="EnsemblGenomes-Tr:CAB15490" /db_xref="GOA:O06965" /db_xref="SubtiList:BG12393" /db_xref="UniProtKB/Swiss-Prot:O06965" /translation="MKKIIFICFSLLLALTGGCSMNDNDKNSTNDNKTEAVKPKDMDP KDLPQVPAFQDEKTREYMVSTKEEEPGYYLLESKLKGFRMLFPEDGKYLSRRSSLTGK NKESIGFNSYDKDTNVMFDGHVTYYKEESFANEPKTMLDIVSGKNDYKGEYKKSSKKK TDIYTAKKKDIFDDIDRKYNYSYSYFGYVKSTEEDNLGVEYAFTLGCKNENQPCSLDE EKAKNKVEKLINSITFLIDKKEK*" /label="yvcA CDS" gene complement(3066279..3067004) /gene="yvcA" /locus_tag="BSU_34850" /old_locus_tag="BSU34850" /label="yvcA gene" S_feature complement(3067005..3067093) /Source="Nicolas_S_feature" /locus_tag="new_3582691_3582779_c" /HighExp="T1.30H, T0.30H, T1.0H, T2.0H, T2.30H, T3.0H, T-1.40H, T-1.10H, MG 150, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1330" promotor_-10 complement(3067093..3067112) /Source="Nicolas_upshift_promotors" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3067093) /Source="Nicolas_upshifts" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3067095..3067224) /Source="Nicolas_S_feature" /locus_tag="new_3582781_3582910_c" /HighExp="Etha, Diami, HiTm, T1.0H, Cold, MG 15, T0.30H, BMM, T1.30H, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1331" promotor_-35 complement(3067128..3067131) /Source="Nicolas_upshift_promotors" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3067250..3067879) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /EC_number="3.5.4.19" /EC_number="3.6.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15871048, 17767732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase" /protein_id="NP_391366.1" /db_xref="EnsemblGenomes-Gn:BSU34860" /db_xref="EnsemblGenomes-Tr:CAB15491" /db_xref="GOA:O34912" /db_xref="InterPro:IPR002496" /db_xref="InterPro:IPR008179" /db_xref="InterPro:IPR021130" /db_xref="InterPro:IPR023019" /db_xref="InterPro:IPR026660" /db_xref="SubtiList:BG12603" /db_xref="UniProtKB/Swiss-Prot:O34912" /translation="MKQADELRFNEDGLIPAIVQDAASKEVLTLAYMNKESYEKTLET KETWFYSRSRQALWHKGETSGNTQAVKGIRYDCDQDALLVLVEPSGPACHTGSYSCFT KEQTEEQAADRFGIMNELERVIAERQAEMPEGAYTTYLFREGVDKILKKVGEEASEVI IAAKNRDHEELKWEAADLLYHLLVLLREQSLPLDDVLDVLKKRHSEIEE*" /label="hisIE CDS" gene complement(3067250..3067879) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /label="hisIE gene" downshifts complement(3067269) /Source="Nicolas_upshifts" /id="D1808" /incds=0 /nref=104 /ntot=178 /MaxReadThrough="4.37156" /MaxDrop="4.76747" /score="14.9565762" /energy="-8.4" /TU="U2738" /idTUdmin="U2735" /TUdmin="-3256" /isTUend="FALSE" /label="downshifts" CDS complement(3067876..3068634) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /EC_number="4.3.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 17767732, 19636909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase subunit" /protein_id="NP_391367.1" /db_xref="EnsemblGenomes-Gn:BSU34870" /db_xref="EnsemblGenomes-Tr:CAB15492" /db_xref="GOA:O34727" /db_xref="InterPro:IPR004651" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG12600" /db_xref="UniProtKB/Swiss-Prot:O34727" /translation="MITKRIIPCLDVKEGRVVKGIQFLELKDAGDPVELAEVYDREGA DELVFLDISASHEGRKTMVDVVEQVAAKLAIPFTVGGGINQLSDMKTILRAGADKVSV NTAAVLRPELITEGAEFFGSQCIVLAIDAKYDKESDTYKVYTHGGRKKTDWEVTAWAK EGVKRGAGEILLTSMDSDGEKKGFDHTLTKLVSEAVPVPVIASGGAGNAQHMLEAFTK GEADAALAASIFHYKETSIKEVKSYLKEYGVNVR*" /label="hisF CDS" gene complement(3067876..3068634) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /label="hisF gene" CDS complement(3068631..3069368) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /EC_number="5.3.1.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 26294764; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase" /protein_id="NP_391368.1" /db_xref="EnsemblGenomes-Gn:BSU34880" /db_xref="EnsemblGenomes-Tr:CAB15493" /db_xref="GOA:O35006" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR006063" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023016" /db_xref="SubtiList:BG12597" /db_xref="UniProtKB/Swiss-Prot:O35006" /translation="MSAFTLYPAIDMRNGKCVRLVQGDYNKETIYGDSPYDMAELFEK EGAEWIHLVDLDGAKEGKRVNDRHVIEIAQKLNLKVEIGGGIRSENDVYEYLSAGVER VILGSSAVSNPPFVKKMLKQYGEKIAIGLDARNGFVSTEGWLETSTLKATELGKELAN EGAEVFIFTDIATDGMLSGPNVKSTVELAKETGKSVIASGGVSSVADLEALARNEADG VSGAIIGKALYTNQFTLSEALERVKRK*" /label="hisA CDS" gene complement(3068631..3069368) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /label="hisA gene" CDS complement(3069365..3070003) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /EC_number="2.4.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 15301532" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 15301532; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase, glutamineamidotransferase subunit" /protein_id="NP_391369.1" /db_xref="EnsemblGenomes-Gn:BSU34890" /db_xref="EnsemblGenomes-Tr:CAB15494" /db_xref="GOA:O34565" /db_xref="InterPro:IPR010139" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12602" /db_xref="UniProtKB/Swiss-Prot:O34565" /translation="MIGVIDYGMGNLYSVSKALERVGVPYFVSEKPEELKEADAFILP GVGSFGDAMDNLGYTKLDQLIHDMVSEGRLLLGICLGMQLLFEESEENGTASGLGLLK GKAVRLKAEDEKGNKLKVPHMGWNRLSFHNESPLLTKTEQGYAYFVHSYYIDGMEENA LLASADYGVRVPAVVGKRNVFGAQFHPEKSSTVGMSILTQFTKMAAEQKVKK*" /label="hisH CDS" gene complement(3069365..3070003) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /label="hisH gene" promotor_no_box 3069861..3069961 /Source="Nicolas_upshift_promotors" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3069921 /Source="Nicolas_upshifts" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3070004..3070588) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /EC_number="4.2.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 24311587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazoleglycerol-phosphate dehydratase [Mn(II)-dependent]" /protein_id="NP_391370.1" /db_xref="EnsemblGenomes-Gn:BSU34900" /db_xref="EnsemblGenomes-Tr:CAB15495" /db_xref="GOA:O34683" /db_xref="InterPro:IPR000807" /db_xref="InterPro:IPR020565" /db_xref="InterPro:IPR020568" /db_xref="SubtiList:BG12598" /db_xref="UniProtKB/Swiss-Prot:O34683" /translation="MRKAERVRKTNETDIELAFTIDGGGQADIKTDVPFMTHMLDLFT KHGQFDLSINAKGDVDIDDHHTTEDIGICLGQALLEALGDKKGIKRYGSAFVPMDEAL AQVVIDLSNRPHLEMRADFPAAKVGTFDTELVHEFLWKLALEARMNLHVIVHYGTNTH HMIEAVFKALGRALDEATTIDPRVKGIPSTKGML*" /label="hisB CDS" gene complement(3070004..3070588) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /label="hisB gene" CDS complement(3070585..3071868) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /EC_number="1.1.1.23" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10353847, 10353848, 21672513, 24140957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol dehydrogenase" /protein_id="NP_391371.1" /db_xref="EnsemblGenomes-Gn:BSU34910" /db_xref="EnsemblGenomes-Tr:CAB15496" /db_xref="GOA:O34651" /db_xref="InterPro:IPR001692" /db_xref="InterPro:IPR012131" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR022695" /db_xref="SubtiList:BG12599" /db_xref="UniProtKB/Swiss-Prot:O34651" /translation="MKIKTISGAERLSLKRSIDAGTEEQRKTVRSIIEDVKANGDQAV RSYTAKFDCIEIDSPLVTKEEFEEAYTSLDSRLLQVIRQAIENIREYHERQLQSSWFY HRKDGTMLGQKVTALDSAGVYVPGGTAAYPSSVLMNVIPALVAGVERIVLVTPPGKDG LLSPGVLVAAAELGIKDIYKMGGAQAIAALAYGTETIEPVDKITGPGNIYVALAKREV FGDVDIDMIAGPSEIVVLADETAIPSEIAADLLSQAEHDKLSSCVFVTDSMALAETVS AEVNKQLETLPRREIAEASVRDYGCIYVAETMVEAIETVNTLAPEHLEIITQSPEALL GSIKHAGAIFLGRYSPEPVGDYFAGPNHVLPTNGTARFSSPLNVTDFQKKSSIISYSQ SAFEEHAESIAAFARLEGLEAHARSIEARERRISK*" /label="hisD CDS" gene complement(3070585..3071868) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /label="hisD gene" CDS complement(3071865..3072506) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /EC_number="2.4.2.17" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 14741209, 15660995, 17154531, 21774583, 22989207, 28092443, 28872824; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP phosphoribosyltransferase" /protein_id="NP_391372.1" /db_xref="EnsemblGenomes-Gn:BSU34920" /db_xref="EnsemblGenomes-Tr:CAB15497" /db_xref="GOA:O34520" /db_xref="InterPro:IPR001348" /db_xref="InterPro:IPR013820" /db_xref="InterPro:IPR018198" /db_xref="InterPro:IPR024893" /db_xref="PDB:2VD2" /db_xref="SubtiList:BG12601" /db_xref="UniProtKB/Swiss-Prot:O34520" /translation="MGKLLTMAMPKGRIFEEAAGLLRQAGYRLPEEFEDSRKLIIDVP EENLRFILAKPMDVTTYVEHGVADVGIAGKDVMLEEERDVYEVLDLNISKCHLAVAGL PNTDWSGVAPRIATKYPNVASSYFREQGEQVEIIKLNGSIELAPLIGLADRIVDIVST GQTLKENGLVETEHICDITSRFIVNPVSYRMKDDVIDEMASRLSLVVEGETAK*" /label="hisG CDS" gene complement(3071865..3072506) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /label="hisG gene" CDS complement(3072499..3073674) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /EC_number="2.4.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 15660995; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase-like subunit of ATP phophoribosyltransferase" /protein_id="NP_391373.1" /db_xref="EnsemblGenomes-Gn:BSU34930" /db_xref="EnsemblGenomes-Tr:CAB15498" /db_xref="GOA:O34459" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR004517" /db_xref="InterPro:IPR006195" /db_xref="SubtiList:BG12606" /db_xref="UniProtKB/Swiss-Prot:O34459" /translation="MFMFEKPHGMRDTLPGLYETKKKVRRSLTDLIDKWGYQFMETPT LEFYDTVGVQSAIEEQQLFKLLDQDGKTLVLRPDMTGPIARVAASKLLKHGHPLRVGY AANVFRAQEREGGRPAEFEQVGVELIGDGTTSADAEVIALVVGALKNAGLASFKIAIG HAGIADALFVEVLGNVERADVLRRFLYEKNYVGYREHVKSLPLSSIDKSRLLELLELR GGIEVCGRAEEIVDSAQGKSVVDELKALWDILEDYGCTENVRLDLNMVSHMSYYTGIL FEVYAENVGFVIGSGGRYNKLLGHFDSPAPATGFGLRIDRLIEALHMKDEPCEIDAVI FSKEQRAQAIAYANEERMKGNKVVLQDLSGIENIDQMTKSFANVTYFIGARKEEQNG* " /label="hisZ CDS" gene complement(3072499..3073674) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /label="hisZ gene" S_feature complement(3073675..3073752) /Source="Nicolas_S_feature" /locus_tag="new_3589361_3589438_c" /HighExp="Diami, M/G, Etha, BMM, MG 15, MG 10, T-1.10H, T-0.40H, T-1.40H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1332" promotor_-35 3073718..3073724 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3073736..3073755 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3073736..3073755) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3073749 /Source="Nicolas_upshifts" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3073752) /Source="Nicolas_upshifts" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3073768..3073775) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3073884..3073903 /Source="Nicolas_upshift_promotors" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3073891 /Source="Nicolas_upshifts" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="upshifts" CDS 3073925..3074677 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydratase" /protein_id="NP_391374.1" /db_xref="EnsemblGenomes-Gn:BSU34940" /db_xref="EnsemblGenomes-Tr:CAB15499" /db_xref="InterPro:IPR016997" /db_xref="SubtiList:BG14130" /db_xref="UniProtKB/Swiss-Prot:O34735" /translation="MKTLRTLCVLMILSGVIFFGLKIDAKDIDIPFLNSLKKVVSDSD TDSAANSKKELKGSAKPLDVILYNQMDAPRLYNGCEVTSLAMVLNYAGYDVTKNTLAN QVATVPLTYSSGLKGDPNDGFVGDMANGPGLGVYHRPIYQLAKTYAGDKVSDLTGKSI SAVYQQLEKGNPVWVITTANFTPVDNMQTWKTPNGTIEITYSEHSVAVTGYDDKYVYL NDPYGYKNRKTDRTSFEKAWKQMGSQAVVIQK*" /label="yvpB CDS" gene 3073925..3074677 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /label="yvpB gene" S_feature 3074678..3074916 /Source="Nicolas_S_feature" /locus_tag="new_3590364_3590602" /HighExp="LBGstat, LPhT, Cold, Sw, M/G, G180, G135, LBGtran, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1333" promotor_-10 complement(3074699..3074710) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3074705) /Source="Nicolas_upshifts" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3074725..3074731) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3074917..3075582 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658655, 15187182, 16514142, 20000851, 24236123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658655, 15187182, 16514142, 20000851, 24236123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted pectate (polygalacturonate) lyase" /protein_id="NP_391375.1" /db_xref="EnsemblGenomes-Gn:BSU34950" /db_xref="EnsemblGenomes-Tr:CAB15500" /db_xref="GOA:O34310" /db_xref="InterPro:IPR004898" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG14129" /db_xref="UniProtKB/Swiss-Prot:O34310" /translation="MKKIVSILFMFGLVMGFSQFQPSTVFAADKVVHETIIVPKNTTY DGKGQRFVAGKELGDGSQSENQDPVFRVEDGATLKNVVLGAPAADGVHTYGNVNIQNV KWEDVGEDALTVKKEGKVTIDGGSAQKASDKIFQINKASTFTVKNFTADNGGKFIRQL GGSTFHVDVIIDKCTITNMKEAIFRTDSKTSTVRMTNTRYSNVGQKWIGVQHIYENNN TQF*" /label="pelC CDS" gene 3074917..3075582 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /label="pelC gene" downshifts 3075553 /Source="Nicolas_upshifts" /id="D1809" /incds=0 /nref=85 /ntot=213 /MaxReadThrough="1.40389" /MaxDrop="4.93342" /score="16.0973385" /energy="-14.9" /TU="NA" /idTUdmin="U2739" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(3075602..3076120) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21761520, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21761520, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphorylated heptaprenylglyceryl phosphate O-acetyltransferase" /protein_id="NP_391376.1" /db_xref="EnsemblGenomes-Gn:BSU34960" /db_xref="EnsemblGenomes-Tr:CAB15501" /db_xref="GOA:O34993" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="SubtiList:BG14128" /db_xref="UniProtKB/Swiss-Prot:O34993" /translation="MRKTDRHPVSGANSLWHVYQTVPFLKVVKNFIVIQIARYTPFIG MKNWLYRTFLRMKVGKQTSFALMVMPDIMFPEKISVGTNTIIGYNTTILAHEYLIHEY RIGKVLIGDEVMIGANTTILPGVKIGDGAVVSAGTLVHKDVPDGAFVGGNPMRIIYTK EEMQERLKKSAE*" /label="hprF CDS" gene complement(3075602..3076120) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /label="hprF gene" downshifts complement(3075636) /Source="Nicolas_upshifts" /id="D1810" /incds=0 /nref=245 /ntot=283 /MaxReadThrough="1.27998" /MaxDrop="6.44997" /score="38.2106579" /energy="-14.9" /TU="NA" /idTUdmin="U2741" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3076124..3076774) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /EC_number="3.6.1.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9465101, 12359880, 12411438, 16182622, 22353596" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9465101, 12359880, 12411438, 16182622, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Hpr-associated pyrophosphatase" /protein_id="NP_391377.1" /db_xref="EnsemblGenomes-Gn:BSU34970" /db_xref="EnsemblGenomes-Tr:CAB15502" /db_xref="GOA:Q9JMQ2" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023733" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14127" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ2" /translation="MSDKQVTTILFDLDGTLINTNELIIASFLHTLEHYYPSKYKRED VLAFIGPSLFDTFSSMDPDKCEDMIAMYRAYNHDMHDSLVTEYETVYETLDALKKAGF TLGIVTTKLRDTVNMGLKLTGIGEFFETVVTLDDVTNAKPDPEPVLLALKQLGSEPAE AIMVGDNYHDVLAGKNAGTKTAGVAWTIKGPEMLAKHEPDFMLEKMSDLLQIVGVK*" /label="ppaX CDS" gene complement(3076124..3076774) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /label="ppaX gene" CDS complement(3076771..3077709) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27226549; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with nucleotide binding domain" /protein_id="NP_391378.1" /db_xref="EnsemblGenomes-Gn:BSU34980" /db_xref="EnsemblGenomes-Tr:CAB15503" /db_xref="GOA:O34382" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG14126" /db_xref="UniProtKB/Swiss-Prot:O34382" /translation="MKKIFLAGLAAGFQTTWTLGKVIFPVTLLVTLLQHTPVMDWLVR LITPVMGLFGLSGEAAIPLVLGNMLNLYAGIAGILTLDLSVKEVFILAVMLSFCHNLI IESTVAAKVGIRIGVILAVRIGLAAVSAIVINLIWHGGKETAQYGFIAAKSAAPDSWL GMLAEALTKAGLGVLQLAAIVIPLMIIIQFLRDLGWLYRFSRWLSPFTQLLGMNKNTS MTMVTGLTIGLAYGAGVMIKAVEDDGVSKRDMTLAFIFLVACHAVVEDTLVFIPLGIP VWPLLLIRVTTAVLLTMAIAHTWKKWKPSAVGKEAI*" /label="yvoD CDS" gene complement(3076771..3077709) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /label="yvoD gene" CDS complement(3077733..3078542) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /EC_number="2.4.99.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prelipoprotein diacylglycerol transferase" /protein_id="NP_391379.1" /db_xref="EnsemblGenomes-Gn:BSU34990" /db_xref="EnsemblGenomes-Tr:CAB15504" /db_xref="GOA:O34752" /db_xref="InterPro:IPR001640" /db_xref="SubtiList:BG12611" /db_xref="UniProtKB/Swiss-Prot:O34752" /translation="MNEAIEPLNPIAFQLGPLAVHWYGIIIGLGALLGLWIAMRESEK RGLQKDTFIDLVLFAIPIAIICARIYYVAFEWDYYAAHPGEIIKIWKGGIAIHGGLIG AILTGYVFSRVKNLSFWKLADIAAPSILLGQAIGRWGNFMNQEAHGEAVSRAFLENLH LPEFIINQMYINGQYYHPTFLYESLWSFVGVIVLLLLRRANLRRGEMFLIYIIWYSIG RYFIEGMRTDSLMLTDSLRIAQVISIVLIVLAVAAIIFRRVKGYSKERYAE*" /label="lgt CDS" gene complement(3077733..3078542) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /label="lgt gene" CDS complement(3078556..3079488) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /EC_number="2.7.4.-" /EC_number="2.7.11.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine protein kinase/phosphorylase (pyrophosphate-producing)" /protein_id="NP_391380.1" /db_xref="EnsemblGenomes-Gn:BSU35000" /db_xref="EnsemblGenomes-Tr:CAB15505" /db_xref="GOA:O34483" /db_xref="InterPro:IPR003755" /db_xref="InterPro:IPR011104" /db_xref="InterPro:IPR011126" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG14125" /db_xref="UniProtKB/Swiss-Prot:O34483" /translation="MAKVRTKDVMEQFNLELISGEEGINRPITMSDLSRPGIEIAGYF TYYPRERVQLLGKTELSFFEQLPEEEKKQRMDSLCTDVTPAIILSRDMPIPQELIDAS EKNGVPVLRSPLKTTRLSSRLTNFLESRLAPTTAIHGVLVDIYGVGVLITGKSGVGKS ETALELVKRGHRLVADDCVEIRQEDQDTLVGNAPELIEHLLEIRGLGIINVMTLFGAG AVRSNKRITIVMNLELWEQGKQYDRLGLEEETMKIIDTEITKLTIPVRPGRNLAVIIE VAAMNFRLKRMGLNAAEQFTNKLADVIEDGEQEE*" /label="hprK CDS" gene complement(3078556..3079488) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /label="hprK gene" promotor_-10 complement(3079530..3079549) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3079536) /Source="Nicolas_upshifts" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3079565..3079570) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3079605..3079612 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3079624 /Source="Nicolas_upshifts" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3079627..3079644 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3079670..3080860 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /EC_number="3.5.1.25" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6774970, 14557261, 21602348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6774970, 14557261, 21602348; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosamine-6-phosphate deacetylase" /protein_id="NP_391381.1" /db_xref="EnsemblGenomes-Gn:BSU35010" /db_xref="EnsemblGenomes-Tr:CAB15506" /db_xref="GOA:O34450" /db_xref="InterPro:IPR003764" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2VHL" /db_xref="SubtiList:BG12630" /db_xref="UniProtKB/Swiss-Prot:O34450" /translation="MAESLLIKDIAIVTENEVIKNGYVGINDGKISTVSTERPKEPYS KEIQAPADSVLLPGMIDIHIHGGYGADTMDASFSTLDIMSSRLPEEGTTSFLATTITQ EHGNISQALVNAREWKAAEESSLLGAELLGIHLEGPFVSPKRAGAQPKEWIRPSDVEL FKKWQQEAGGLIKIVTLAPEEDQHFELIRHLKDESIIASMGHTDADSALLSDAAKAGA SHMTHLYNAMSPFHHREPGVIGTALAHDGFVTELIADGIHSHPLAAKLAFLAKGSSKL ILITDSMRAKGLKDGVYEFGGQSVTVRGRTALLSDGTLAGSILKMNEGARHMREFTNC SWTDIANITSENAAKQLGIFDRKGSVTVGKDADLVIVSSDCEVILTICRGNIAFISKE ADQI*" /label="nagA CDS" gene 3079670..3080860 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /label="nagA gene" promotor_-35 3080658..3080664 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3080679 /Source="Nicolas_upshifts" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3080680..3080698 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3080857..3081585 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /EC_number="3.5.99.6" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15755726, 18436239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 18436239; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate isomerase" /protein_id="NP_391382.1" /db_xref="EnsemblGenomes-Gn:BSU35020" /db_xref="EnsemblGenomes-Tr:CAB15507" /db_xref="GOA:O35000" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="PDB:2BKV" /db_xref="PDB:2BKX" /db_xref="SubtiList:BG12631" /db_xref="UniProtKB/Swiss-Prot:O35000" /translation="MKVMECQTYEELSQIAARITADTIKEKPDAVLGLATGGTPEGTY RQLIRLHQTENLSFQNITTVNLDEYAGLSSDDPNSYHFYMNDRFFQHIDSKPSRHFIP NGNADDLEAECRRYEQLVDSLGDTDIQLLGIGRNGHIGFNEPGTSFKSRTHVVTLNEQ TRQANARYFPSIDSVPKKALTMGIQTILSSKRILLLISGKSKAEAVRKLLEGNISEDF PASALHLHSDVTVLIDREAASLRP*" /label="nagBA CDS" gene 3080857..3081585 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /label="nagBA gene" CDS 3081603..3082334 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /experiment="publication(s) with functional evidences, PMID:16207374, 20047956, 21602348, 23667565, 24673833, 26162881" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 20047956, 21602348, 23667565, 24673833, 26162881; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_391383.1" /db_xref="EnsemblGenomes-Gn:BSU35030" /db_xref="EnsemblGenomes-Tr:CAB15508" /db_xref="GOA:O34817" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2WV0" /db_xref="PDB:4U0V" /db_xref="PDB:4U0W" /db_xref="PDB:4U0Y" /db_xref="PDB:4WWC" /db_xref="SubtiList:BG14124" /db_xref="UniProtKB/Swiss-Prot:O34817" /translation="MNINKQSPIPIYYQIMEQLKTQIKNGELQPDMPLPSEREYAEQF GISRMTVRQALSNLVNEGLLYRLKGRGTFVSKPKMEQALQGLTSFTEDMKSRGMTPGS RLIDYQLIDSTEELAAILGCGHPSSIHKITRVRLANDIPMAIESSHIPFELAGELNES HFQSSIYDHIERYNSIPISRAKQELEPSAATTEEANILGIQKGAPVLLIKRTTYLQNG TAFEHAKSVYRGDRYTFVHYMDRLS*" /label="nagR CDS" gene 3081603..3082334 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /label="nagR gene" CDS complement(3082354..3086223) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_391384.1" /db_xref="EnsemblGenomes-Gn:BSU35040" /db_xref="EnsemblGenomes-Tr:CAB15509" /db_xref="GOA:O34986" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR011401" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036415" /db_xref="SubtiList:BG14123" /db_xref="UniProtKB/Swiss-Prot:O34986" /translation="MRKYTVIASILLSFLSVLSGGHHESKAFPVVQQELFQTPHYIPL LENPPQIDVKAEMRSNLMIEAQVRDNSYQAFSAFLFYKQSNELGYKMVPMDPTPGAVR KFLAQIPKRLIWNSELEYYIVMSNGKQRVESETKKLKLEGYQADLAHIPELLITELAV DTKNIGRADGYEFIEIFNTTDRTIDFKDYHIRYRYPKEGPDSDLIWRPDERILIPSGE TFVVWLKPAGHPELTSADFNRYYQTQLKEGKNLAVIDETEGMANTRPRAVVISTNTGK DISVAHYRKHALRRLSSVLYKYPLNGTAELLNISIGEKNPSPGTVLQAQVPDQKRKIK LDKEKPVIEDLTDRKPVRPAESIELRADIRDRSLVKTVAFYYRTDENKPFKRILAEKD RNDNLFHYIVYSPELIGKDQLEYYVAAGDGINEARTPVKMIDIKQTSKAHGLRMNIEN RDTLSGTQFLKATTEGRADSIKLWIDGKKQVTEPAMEKEVYFAFDTRKTNLYFKNAVT MEGKVLKVFDDTTNKYRTYSVPLPETLLRKGKQLQRITIRSGSKVSPFDTAENRDDFL VKNARLVLSDGTVIRDQRVSPEKELFIGDNQRSNKSWQFQFNLPDGLFTSQLLEWDTS KLSEGAHHIQASDGKENVSLVVRVDNSGPHIEPNITEGQTYKGNLILQADMYDKWSRI EEAEASLDGESITLPYHTSSSDLLPGKHSLKVTATDLAGNKTVIERIFKTEREHPDQP EVIDSEADTHKAKLSVRVKDPTNDAMDVGFYRGFQYTARNHVKIFKHASLTEPPKSFV PERETPFTNKELERVSAADGKTVSTENKELFPYHRFEVTVDPSIDENDLAESVWKGSS LPGRKVTMYAWNYRTNEWQPVDSFVAKDDKPFTLKASVIAADFVRESKMNVIVQDEIP PAKDMYTFVWMSDTQYYAESYPHIFDKQTEWIKDNQKQLNIKYVFHTGDIVDDSADIR QWKNADRSMSVLDKSGIPYGVLAGNHDVGHKDGSYRAFGKYFGSDRFDKKFHYGGSYK NNRGHYDLISSNGNDYIMLYMGWGITDEDIAWMNQVLKKHPDRMAILAFHEYLLVSGN RSPIGEKIFKEIVKPNPNVVMVLSGHYHSAMRKTDELDDDGDGKPDRLVHQMLADYQG GPEGGQGYLRLLQFDQANDMVHVSTYSPYVKDKNYYDTDTYGNKDEFSLSLDLKPRIK KVETDYFECNVYTNEELGKREQVKSGDTAEFRWDHLEPQSVYYWYIIVEDSFNGKTKS PIWKFKTKKETYRPAPDQFDFRHVSNP*" /label="yvnB CDS" gene complement(3082354..3086223) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /label="yvnB gene" downshifts complement(3082476) /Source="Nicolas_upshifts" /id="D1811" /incds=1 /nref=19 /ntot=109 /MaxReadThrough="1.28942" /MaxDrop="4.39575" /score="28.0438848" /energy="-16.5" /TU="NA" /idTUdmin="U2744" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3086243..3086254) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3086250) /Source="Nicolas_upshifts" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3086269..3086275) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3086313..3086319 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3086333..3086352 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3086338 /Source="Nicolas_upshifts" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="upshifts" CDS 3086388..3086861 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391385.1" /db_xref="EnsemblGenomes-Gn:BSU35050" /db_xref="EnsemblGenomes-Tr:CAB15510" /db_xref="GOA:O34692" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14122" /db_xref="UniProtKB/Swiss-Prot:O34692" /translation="MDNSIHDELFQAIQQFALKRDKRVWQKVQIPSIGISSQHHDHLK KDWTLTQLHIVSCIHTSQNVNNSFLASRLHISKAAVSKAVHALLKHNIITVTKKPGNK KEIFYTLTDSGRKLAALHEQLHEKAKEQYKQLFNEFSIDDLKTVTAFFNLWIKYM*" /label="yvnA CDS" gene 3086388..3086861 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /label="yvnA gene" S_feature 3086862..3086969 /Source="Nicolas_S_feature" /locus_tag="new_3602548_3602655" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, T2.30H, M9-stat, T2.0H, T1.30H, T1.0H, BC" /AntisenseName="cypX" /AntisenseCor="-1.1473096183385199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1334" CDS complement(3086902..3088119) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /EC_number="1.14.-.-" /function="16.5: Explore" /function="16.14: Store" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:4204912, 20690619, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 20690619, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclo-L-leucyl-L-leucyl dipeptide oxidase, pulcheriminic synthase" /protein_id="NP_391386.1" /db_xref="EnsemblGenomes-Gn:BSU35060" /db_xref="EnsemblGenomes-Tr:CAB15511" /db_xref="GOA:O34926" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR030904" /db_xref="InterPro:IPR036396" /db_xref="PDB:3NC3" /db_xref="PDB:3NC5" /db_xref="PDB:3NC6" /db_xref="PDB:3NC7" /db_xref="SubtiList:BG12580" /db_xref="UniProtKB/Swiss-Prot:O34926" /translation="MSQSIKLFSVLSDQFQNNPYAYFSQLREEDPVHYEESIDSYFIS RYHDVRYILQHPDIFTTKSLVERAEPVMRGPVLAQMHGKEHSAKRRIVVRSFIGDALD HLSPLIKQNAENLLAPYLERGKSDLVNDFGKTFAVCVTMDMLGLDKRDHEKISEWHSG VADFITSISQSPEARAHSLWCSEQLSQYLMPVIKERRVNPGSDLISILCTSEYEGMAL SDKDILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDVLADRSLVPRAIAETLRY KPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIK SAFSGAARHLAFGSGIHNCVGAAFAKNEIEIVANIVLDKMRNIRLEEDFCYAESGLYT RGPVSLLVAFDGA*" /label="cypX CDS" gene complement(3086902..3088119) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /label="cypX gene" downshifts complement(3086915) /Source="Nicolas_upshifts" /id="D1812" /incds=0 /nref=11 /ntot=50 /MaxReadThrough="2.27112" /MaxDrop="6.67384" /score="-0.264310319" /energy="-11.6" /TU="NA" /idTUdmin="U2747" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3086941..3086946 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3086961..3086972 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3086971..3087256 /Source="Nicolas_S_feature" /locus_tag="new_3602657_3602942" /HighExp="BC, Sw, Lbstat, T5.0H, M9-stat, T4.0H, T3.30H, B60, T1.30H, T0.30H" /AntisenseName="cypX" /AntisenseCor="-4.04991056466339E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.438, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1335" upshifts 3086971 /Source="Nicolas_upshifts" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="upshifts" downshifts 3087213 /Source="Nicolas_upshifts" /id="D1813" /incds=1 /nref=9 /ntot=165 /MaxReadThrough="3.27492" /MaxDrop="3.99509" /score="54.0406126" /energy="-11.4" /TU="U2745,U2746" /idTUdmin="U2746" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(3088135..3088881) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /EC_number="6.-.-.-" /function="16.14: Store" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:4204912, 19430487, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 19430487, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclodipeptide synthase (tRNA-dependent), pulcherimminic acid precursor" /protein_id="NP_391387.1" /db_xref="EnsemblGenomes-Gn:BSU35070" /db_xref="EnsemblGenomes-Tr:CAB15512" /db_xref="GOA:O34351" /db_xref="InterPro:IPR030903" /db_xref="SubtiList:BG14121" /db_xref="UniProtKB/Swiss-Prot:O34351" /translation="MTGMVTERRSVHFIAEALTENCREIFERRRHVLVGISPFNSRFS EDYIYRLIGWAKAQFKSVSVLLAGHEAANLLEALGTPRGKAERKVRKEVSRNRRFAER ALVAHGGDPKAIHTFSDFIDNKAYQLLRQEVEHAFFEQPHFRHACLDMSREAIIGRAR GVSLMMEEVSEDMLNLAVEYVIAELPFFIGAPDILEVEETLLAYHRPWKLGEKISNHE FSICMRPNQGYLIVQEMAQMLSEKRITSEG*" /label="pchC CDS" gene complement(3088135..3088881) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /label="pchC gene" S_feature complement(3088882..3089068) /Source="Nicolas_S_feature" /locus_tag="new_3604568_3604754_c" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T3.0H, T1.0H, B36, BT, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1336" promotor_-10 complement(3089054..3089073) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3089068) /Source="Nicolas_upshifts" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3089087..3089094) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3089202..3089209 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3089224..3089243 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3089236 /Source="Nicolas_upshifts" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="upshifts" S_feature 3089237..3089306 /Source="Nicolas_S_feature" /locus_tag="new_3604923_3604992" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T1.0H, T0.30H, B36, T3.0H, BT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1337" CDS 3089307..3089816 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27542896; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for pulcherriminic acid synthesis" /protein_id="NP_391388.1" /db_xref="EnsemblGenomes-Gn:BSU35080" /db_xref="EnsemblGenomes-Tr:CAB15513" /db_xref="GOA:P40762" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11018" /db_xref="UniProtKB/Swiss-Prot:P40762" /translation="MSDLTKQMIYDIYVRLLHLNEQKANTSLQQFFKEAAEEDVAEIP KNMTSIHVIDCIGQHEPINNAGIARKMNLSKANVTKISTKLIKEEFINSYQLTDNKKE VYFKLTRKGRRIFDLHEKLHKKKELAFYQFLDSFSQEEQKAVLKFLEQLTSTLEAEQT DGTPDKPVK*" /label="pchR CDS" gene 3089307..3089816 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /label="pchR gene" S_feature complement(3089712..3091050) /Source="Nicolas_S_feature" /locus_tag="new_3605398_3606736_c" /HighExp="T0.30H, T1.0H, T1.30H, T-0.40H, T0.0H, T2.0H, G135, T2.30H, T-1.10H, G180" /AntisenseName="yvmA" /AntisenseCor="0.2423954904641" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1338" downshifts complement(3089753) /Source="Nicolas_upshifts" /id="D1814" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.42525" /MaxDrop="2.72496" /score="14.1278884" /energy="-7.8" /TU="NA" /idTUdmin="U2749" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3089837..3091048 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27542896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pulcherriminic acid efflux transporter" /protein_id="NP_391389.1" /db_xref="EnsemblGenomes-Gn:BSU35090" /db_xref="EnsemblGenomes-Tr:CAB15514" /db_xref="GOA:O34307" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14120" /db_xref="UniProtKB/Swiss-Prot:O34307" /translation="MAHTKSKAVLILYTVCFSAFFASLSQNIYSPILPIIKESFHVST AMVNLSVSVFMIVTAIMQIILGAIIDFKGARIVLITGILATAAASIGCAVTTDFTLFL IFRMIQAAGSAALPLIAATTIGQLFTGNERGSAMGTYQMLLSVAPAIAPVLGGFIGGA AGYEGIFWILAAISIVLLVTNSITFPKDSPTESMQQAKGNVFAHYKSIFTNRTGNVIL TLSFVLFFIYFAVIVYLPILLTEHYHIDVGIAGLLYLPLALSTIAGTFLFKRIQAKIG LHTLFIGSNVIAACSIILFAVTHSVSLVLMALTLALFGISMGVIPPLYSTMITNEFEH NRGSAIGMFNFIRYTGMAAGPMVSAYLLTMMPSAMSFSLLGLGFAALSFCLLPPMFSP QKRTKQKKHHM*" /label="pchE CDS" gene 3089837..3091048 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /label="pchE gene" downshifts 3091046 /Source="Nicolas_upshifts" /id="D1815" /incds=0 /nref=33 /ntot=196 /MaxReadThrough="5.27186" /MaxDrop="4.73361" /score="54.0406126" /energy="-11.4" /TU="U2748" /idTUdmin="U2748" /TUdmin="-721" /isTUend="FALSE" /label="downshifts" CDS complement(3091076..3091435) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26296725; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral phage holin-like membrane protein" /protein_id="NP_391390.1" /db_xref="EnsemblGenomes-Gn:BSU35100" /db_xref="EnsemblGenomes-Tr:CAB15515" /db_xref="GOA:O34648" /db_xref="InterPro:IPR007165" /db_xref="SubtiList:BG14119" /db_xref="UniProtKB/Swiss-Prot:O34648" /translation="MVKWAVSILVNALLLIVIDGYIDSIHISSIGAAIIASLILSILN VLIKPLLIIFTLPVTMVTLGLFLFVINAITLMMTASIMGDSFQIDGFGTAIWASVILS VFHLLIQKGILEPLRKK*" /label="yvlD CDS" gene complement(3091076..3091435) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /label="yvlD gene" S_feature 3091091..3091807 /Source="Nicolas_S_feature" /locus_tag="new_3606777_3607493" /HighExp="LBGstat, S8, Gly, C30, G135, S7, C90, Sw, Fru, S6" /AntisenseName="yvlC" /AntisenseCor="0.178445666283919" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1339" downshifts complement(3091095) /Source="Nicolas_upshifts" /id="D1816" /incds=0 /nref=129 /ntot=265 /MaxReadThrough="4.63835" /MaxDrop="5.15146" /score="14.4434545" /energy="-9.6" /TU="U2749" /idTUdmin="U2751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3091437..3091634) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23980836; Product type r : regulator" /codon_start=1 /transl_table=11 /product="membrane associated phage-like stress regulator,nisin resistance" /protein_id="NP_391391.1" /db_xref="EnsemblGenomes-Gn:BSU35110" /db_xref="EnsemblGenomes-Tr:CAB15516" /db_xref="GOA:O34719" /db_xref="InterPro:IPR007168" /db_xref="SubtiList:BG14118" /db_xref="UniProtKB/Swiss-Prot:O34719" /translation="MNKLYRSEKNKKIAGVIGGLAEYFNWDASLLRVITVILAIMTSV LPVLLIYIIWIFIVPSERDMK*" /label="yvlC CDS" gene complement(3091437..3091634) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /label="yvlC gene" CDS complement(3091639..3092736) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function, stress-related" /protein_id="NP_391392.1" /db_xref="EnsemblGenomes-Gn:BSU35120" /db_xref="EnsemblGenomes-Tr:CAB15517" /db_xref="InterPro:IPR016599" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14117" /db_xref="UniProtKB/Swiss-Prot:O34628" /translation="MKQEKERILKLVEEGKLTAQEALTLIEKLDSDYKEKEEKITALS VHVHDEEEPFTTAKKESGKPSLGAKLFDWIDSAVKKVKEVDLDLNFGHAYDVQHIFQF KDTDFSSVELQIANGSVNIVPWEDDDIRAECQAKVYRADSQDAARHAFLQHIECEIKG NKFFIRTEKKTMKTNVTLYIPQKEYDKIRVKLFNGPVRGEHLHVKEFSAKTTNGVLSF SYLTAEKAIAETANGQIKLASHSCGTIEAETINGLIDLRGKSESIDVQSFNGNIAINV TESDCRSIYAKTTTGNVELAIPDDLAVKAELKSNLGTLSHELMDVEMLKEKNDTIQKE MMFTSNQAHDQNITVFSESLTGAIKLKYSQR*" /label="yvlB CDS" gene complement(3091639..3092736) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /label="yvlB gene" CDS complement(3092761..3093087) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391393.1" /db_xref="EnsemblGenomes-Gn:BSU35130" /db_xref="EnsemblGenomes-Tr:CAB15518" /db_xref="GOA:O34322" /db_xref="SubtiList:BG14116" /db_xref="UniProtKB/Swiss-Prot:O34322" /translation="MNRNQAIIASLCYFSVFIAPIIVPIVAYFVVNEKETKRHAIRSL ISHIVPFVGWLFLFIALLGGAVAIDGDSLLPVFVIIGGAVIYFLVVIGIIIWNVIQGI KVLRAA*" /label="yvlA CDS" gene complement(3092761..3093087) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /label="yvlA gene" promotor_-10 complement(3093140..3093155) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3093155) /Source="Nicolas_upshifts" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3093157..3093647) /Source="Nicolas_S_feature" /locus_tag="new_3608843_3609333_c" /HighExp="H2O2, G180, Paraq, G150, G135, dia15, Oxctl, Diami, Lbexp, LBGexp" /AntisenseName="yvkN" /AntisenseCor="0.37678416921083902" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1340" promotor_-35 complement(3093167..3093176) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3093235..3093238 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3093253..3093272 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3093263 /Source="Nicolas_upshifts" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="upshifts" CDS 3093305..3093535 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391394.1" /db_xref="EnsemblGenomes-Gn:BSU35140" /db_xref="EnsemblGenomes-Tr:CAB15519" /db_xref="SubtiList:BG14115" /db_xref="UniProtKB/Swiss-Prot:O34604" /translation="MEKDPSDYTVTQESVLKLIQEQKRMNREMITELEQIHGPFPISH DIQYIKVLLDSSNTHIVQDLMSVSKQLYKKTL*" /label="yvkN CDS" gene 3093305..3093535 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /label="yvkN gene" promotor_-10 complement(3093638..3093657) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-10" upshifts complement(3093648) /Source="Nicolas_upshifts" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="upshifts" promotor_-35 complement(3093673..3093677) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-35" CDS complement(3093734..3094216) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16936039; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="putative flagellin" /db_xref="EnsemblGenomes-Gn:BSU35150" /db_xref="EnsemblGenomes-Tr:CAB15520" /db_xref="GOA:O34366" /db_xref="InterPro:IPR001029" /db_xref="PSEUDO:CAB15520.1" /db_xref="SubtiList:BG14158" /db_xref="UniProtKB/Swiss-Prot:O34366" /translation="MDALIEEVDGISNRTEFNGKKLLDGTETDGFTFQIGANAGQQLT VNIDSMSSTALGVNALNVTDFANTPFDTQLESIDTAINNVSNQRAKLGAVQNRLEHTI NNLGASSENLTAAESRIRDVDMAKEMSEFTKNNIPSQASQAMLAQANQQPQNVLQLLR *" /label="yvzB CDS" gene complement(3093734..3094216) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /pseudo /label="yvzB gene" downshifts 3093742 /Source="Nicolas_upshifts" /id="D1817" /incds=0 /nref=13 /ntot=113 /MaxReadThrough="0.9814" /MaxDrop="4.76969" /score="2.6592903" /energy="-5.7" /TU="NA" /idTUdmin="U2750" /TUdmin=17 /isTUend="TRUE" /label="downshifts" downshifts complement(3093757) /Source="Nicolas_upshifts" /id="D1818" /incds=0 /nref=118 /ntot=206 /MaxReadThrough="2.62918" /MaxDrop="8.97968" /score="25.6132739" /energy="-19.8" /TU="NA" /idTUdmin="U2752" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3093889) /Source="Nicolas_upshifts" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3093897..3093900) /Source="Nicolas_upshift_promotors" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3093977..3093981) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3093977) /Source="Nicolas_upshifts" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3093997..3094000) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3094217..3094350) /Source="Nicolas_S_feature" /locus_tag="new_3609903_3610036_c" /HighExp="H2O2, Sw, M40t45, M40t90, Diami, Salt, dia15, BC, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1341" CDS complement(3094378..3097251) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit A)" /protein_id="NP_391396.1" /db_xref="EnsemblGenomes-Gn:BSU35160" /db_xref="EnsemblGenomes-Tr:CAB15533" /db_xref="GOA:O34863" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004602" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12697" /db_xref="UniProtKB/Swiss-Prot:O34863" /translation="MAMDRIEVKGARAHNLKNIDVTIPRDQLVVVTGLSGSGKSSLAF DTIYAEGQRRYVESLSAYARQFLGQMDKPDVDAIEGLSPAISIDQKTTSRNPRSTVGT VTEIYDYLRLLYARVGKPHCPEHGIEITSQTIEQMVDRILEYPERTKLQVLAPIVSGR KGAHVKVLEQIRKQGYVRVRIDGEMAELSDDIELEKNKKHSIEVVIDRIVVKEGVAAR LSDSLETALRLGEGRVMIDVIGEEELMFSEHHACPHCGFSIGELEPRLFSFNSPFGAC PTCDGLGMKLEVDADLVIPNQDLSLKENAVAPWTPISSQYYPQLLEAVCTHYGIDMDV PVKDLPKHQLDKVLYGSGDDLIYFRYENDFGQIREGEIQFEGVLRNIERRYKETGSDF IREQMEQYMSQKSCPTCKGYRLKKEALAVLIDGRHIGKITELSVADALAFFKDLTLSE KDMQIANLILREIVERLSFLDKVGLDYLTLSRAAGTLSGGEAQRIRLATQIGSRLSGV LYILDEPSIGLHQRDNDRLISALKNMRDLGNTLIVVEHDEDTMMAADYLIDIGPGAGI HGGQVISAGTPEEVMEDPNSLTGSYLSGKKFIPLPPERRKPDGRYIEIKGASENNLKK VNAKFPLGTFTAVTGVSGSGKSTLVNEILHKALAQKLHKAKAKPGSHKEIKGLDHLDK VIDIDQAPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKVRGYKKGRFSFNVKGGRCEA CRGDGIIKIEMHFLPDVYVPCEVCHGKRYNRETLEVTYKGKSISDVLDMTVEDALSFF ENIPKIKRKLQTLYDVGLGYITLGQPATTLSGGEAQRVKLASELHKRSTGRTLYILDE PTTGLHVDDIARLLVVLQRLVDNGDTVLVIEHNLDIIKTADYIVDLGPEGGAGGGTIV ASGTPEEITEVEESYTGRYLKPVIERDKTRMKSLLKAKETATS*" /label="uvrA CDS" gene complement(3094378..3097251) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /label="uvrA gene" downshifts complement(3094395) /Source="Nicolas_upshifts" /id="D1819" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="4.46283" /MaxDrop="5.3695" /score="12.0157254" /energy="-18.6" /TU="U2754,U2756" /idTUdmin="U2755" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3097259..3099244) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit B)" /protein_id="NP_391397.1" /db_xref="EnsemblGenomes-Gn:BSU35170" /db_xref="EnsemblGenomes-Tr:CAB15534" /db_xref="GOA:P37954" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004807" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR024759" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036876" /db_xref="PDB:2D7D" /db_xref="PDB:2NMV" /db_xref="PDB:3V4R" /db_xref="SubtiList:BG10502" /db_xref="UniProtKB/Swiss-Prot:P37954" /translation="MKDRFELVSKYQPQGDQPKAIEKLVKGIQEGKKHQTLLGATGTG KTFTVSNLIKEVNKPTLVIAHNKTLAGQLYSEFKEFFPNNAVEYFVSYYDYYQPEAYV PQTDTFIEKDASINDEIDKLRHSATSALFERRDVIIIASVSCIYGLGSPEEYREMVVS LRTEMEIERNELLRKLVDIQYARNDIDFQRGTFRVRGDVVEIFPASRDEHCVRVEFFG DEIERIREVDALTGEILGDRDHVAIFPASHFVTRAEKMEKAIQNIEKELEEQLKVMHE NGKLLEAQRLEQRTRYDLEMMREMGFCSGIENYSRHLTLRPPGSTPYTLLDYFPDDFM IVVDESHVTIPQVRGMFNGDQARKQVLVDHGFRLPSALDNRPLRFEEFEKHMHNIVYV SATPGPYEIEHTDEMVEQIIRPTGLLDPLIDVRPIEGQIDDLIGEIQARIERNERVLV TTLTKKMSEDLTDYLKEIGIKVNYLHSEIKTLERIEIIRDLRLGKYDVLVGINLLREG LDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNAEGRVIMYADKITKSMEIAINE TKRRREQQERFNEEHGITPKTINKEIRDVIRATVAAEDKAEYKTKAAPKLSKMTKKER QKVVEQMEHEMKEAAKALDFERAAELRDLLLELKAEG*" /label="uvrB CDS" gene complement(3097259..3099244) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /label="uvrB gene" promotor_-10 complement(3099278..3099297) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3099290) /Source="Nicolas_upshifts" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3099292..3099377) /Source="Nicolas_S_feature" /locus_tag="new_3614978_3615063_c" /HighExp="Gly, Sw, B60, BT, LoTm, Salt, Etha, M9-stat, B36, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1342" promotor_-35 complement(3099309..3099316) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3099422) /Source="Nicolas_upshifts" /id="D1820" /incds=0 /nref=4 /ntot=60 /MaxReadThrough="5.68784" /MaxDrop="3.17938" /score="11.285993" /energy="-12" /TU="U2755,U2756" /idTUdmin="U2755" /TUdmin="-5027" /isTUend="FALSE" /label="downshifts" CDS complement(3099430..3099660) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 1592822, 1744042; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_391398.1" /db_xref="EnsemblGenomes-Gn:BSU35180" /db_xref="EnsemblGenomes-Tr:CAB15535" /db_xref="GOA:P37953" /db_xref="InterPro:IPR019242" /db_xref="SubtiList:BG10501" /db_xref="UniProtKB/Swiss-Prot:P37953" /translation="MITKAVFALFFPFMLVVLFTRVTFNHYVAIALTAALLFASYLKG YTETYFIVGLDVVSLVAGGLYMAKKAAEKKEE*" /label="csbA CDS" gene complement(3099430..3099660) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /label="csbA gene" promotor_-10 complement(3099687..3099706) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-10" upshifts complement(3099697) /Source="Nicolas_upshifts" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="upshifts" S_feature complement(3099699..3099763) /Source="Nicolas_S_feature" /locus_tag="new_3615385_3615449_c" /HighExp="Gly, M9-stat, B60, Sw, Etha, LoTm, BT, B36, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1343" promotor_-35 complement(3099720..3099727) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-35" promotor_-10 complement(3099740..3099758) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3099761) /Source="Nicolas_upshifts" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3099773..3099779) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3099829) /Source="Nicolas_upshifts" /id="D1821" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.9693" /MaxDrop="4.37808" /score="-1.92287727" /energy="-4.2" /TU="NA" /idTUdmin="U2761" /TUdmin=4752 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(3099855..3099955) /Source="Nicolas_upshift_promotors" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3099895) /Source="Nicolas_upshifts" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3099977..3099984 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3099998..3100017 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3100015 /Source="Nicolas_upshifts" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3100107..3102602 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /EC_number="2.7.-.-" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25012659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_391399.1" /db_xref="EnsemblGenomes-Gn:BSU35190" /db_xref="EnsemblGenomes-Tr:CAB15536" /db_xref="GOA:O34796" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG14114" /db_xref="UniProtKB/Swiss-Prot:O34796" /translation="MYSVLFRQAEESSQLAGAKGMNLIKLTKHGLPVPDGFIIQTNAL ARFMEDNQLQETSENVEGGIISGTFSDELKDELTSSFYKLRESYRSVAVRSSSASEDL EGASFAGQYETYLNIKTEEEFLAKVKECWASFFSGRVSSYKKKMNNQIAEPLMGIVVQ GLIDSEMSGVIFSRNPVTHDDRELLISASYGLGEAVVSGNVTPDTFIVNKSSFEIQKE IGAKEIYMESAAEGIAEKETSEDMRSRFCLTDEQVIELAEITKKTEDLYGYPVDIEFG IADHQIYLLQARPITTIDQDKKAAEEKRSFMITDTDMNDFWLNMESNIEGPVSPLFSS FIVPALEYGLKKSMQKFPIGVVVDEVKLYRGHIYSKNQGGQQPPSEDCGKELFPILSE HMYDIINHTYLPFYRTLDQLAQTEHTAESALEAFQKLKAFYLTAYEEHFNIVFPQILL TNKLQAMYQDIQGESENAHFYEMLTGKMNKSLETDRCLWLFSVEVQENPNLLAIFENN KPEQLQEKLEQTDEGRHFLKNVHEFLQEYGWRSVKSHDLIEQIWVENPYFALANIQNY VRNGYHFDNEFQKTKEKREKLYNEFLESIEDPGLRTEFDRYYQWTLNSANIKDDHHFY IDAMLDAKARIFLLKIGELLAENGVIQDREDLWFLYDDEVEQALLHPVSLQEKAEKRR QIFHEYELAQAPAYLGTPTKEQLKAAEEIVGAVIEDEKNTENHIFGIAASSGIATGPV KIIRDANEFSQFAPGDVLVCKMTTPLWTSLFQDAKAIITDTGGILSHAAIIAREYGIP AVLGTRTATERLRDGDIITVDGSSGKITVVSRS*" /label="yvkC CDS" gene 3100107..3102602 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /label="yvkC gene" misc_feature 3102617..3102621 /Source="Nicolas_upshift_promotors" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3102635 /Source="Nicolas_upshifts" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="upshifts" CDS 3102678..3103247 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391400.1" /db_xref="EnsemblGenomes-Gn:BSU35200" /db_xref="EnsemblGenomes-Tr:CAB15537" /db_xref="GOA:O34643" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG14113" /db_xref="UniProtKB/Swiss-Prot:O34643" /translation="MRPTNKRILDAAMQLLVKKGYRATTTKEIAEKANVSEATIFRNF KNKQGLVEALLSQHSSNRGSILEQTEGDLYKDLLHIGTCLLEELEHRKDIIKISFREP AMFQDVINHVTEYPQSMKQLLVDYLKTMGEKGVIQTGNEAEHADVFMSIIFGYFIHRL HLGDRVISMPQEKMLEHSTALFVKGISAD*" /label="yvkB CDS" gene 3102678..3103247 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /label="yvkB gene" CDS 3103278..3104612 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391401.1" /db_xref="EnsemblGenomes-Gn:BSU35210" /db_xref="EnsemblGenomes-Tr:CAB15538" /db_xref="GOA:O34502" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14112" /db_xref="UniProtKB/Swiss-Prot:O34502" /translation="MSSRKEWALIVSLLLGAILVPINSTMIAVALSSISHTYNESIAS ITWVVTVYLIVMAVTQPIAGKLGDMYGNKTMYLWGVGLFLIASLGCALSPSLLLLIVF RALQAVGGALLTPNSIAIIRHVVSEKRLPKVFGFFGLGAGLGAALGPFIGSILIDSFS WHSIFWVNIPFLAIALFTALTMFPQYKENKSDAPLDIIGSLLLAGSIVSIILLTKNEA PWGYTVYSVLILLFVPLFFRREKRTQHPIIDFALFKSSTFTNANLSVLLSNLMMYAVL LIMPLFMTNQFGLNTSNSGMALSVFSIFMSASNWVGAQLHHKWGAKKIIFLSFAMMAG ANLLFLLLSSSHSVLFLMLSLILGGLASGVGLTSMQVSSLATVDPGMSGVASGIFSTF RYFGSIISSALIGLISGYHTLFMILFAVSIIGVFVSLGIKSDETARIEKNSA*" /label="yvkA CDS" gene 3103278..3104612 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /label="yvkA gene" downshifts 3104593 /Source="Nicolas_upshifts" /id="D1822" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="0.94661" /MaxDrop="3.57731" /score="21.0606505" /energy="-28.8" /TU="NA" /idTUdmin="U2759" /TUdmin=1276 /isTUend="FALSE" /label="downshifts" CDS complement(3104660..3105853) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16030230, 16850406, 18976281, 19019154, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16030230, 16850406, 18976281, 19019154, 26735940; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="topological determinant of cell division" /protein_id="NP_391402.1" /db_xref="EnsemblGenomes-Gn:BSU35220" /db_xref="EnsemblGenomes-Tr:CAB15539" /db_xref="GOA:O34375" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14111" /db_xref="UniProtKB/Swiss-Prot:O34375" /translation="MSVQWGIELLKSAGLFFLHPLFWFFIIITLAFGYVRIKRERKTF HTRIADIYDDLKFTYTKGLIPGLLLSVILGGLGISIPLGLLAIIAVITAAAAFTLRAN WMSAAYIVSVSMLIGFGLQIYQAEPFLERFPQGFAVVWPAVAVFLGLLIITEGAVAYR SAHVRTSPALVVSSRGLPIGQQLANRVWLLPLFLLVPGNGLESHLSWWPVFTVPGGSF HFLWIPYFVGFGQRVQGSLPETSIRITAKRVCILGLAVAVLGAASLLWTPLAGAAVCT ALLGRIFLSIKQRVNDNAAPFYFSKRDQGLMVLGIIPNTPAEDLELKIGEIITKVNGI PVKNVSDFYEALQHNRAYVKLEIIGLNGEIRFDQRASYEGEHHELGILFVKDDREDEA VASGS*" /label="minJ CDS" gene complement(3104660..3105853) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /label="minJ gene" downshifts complement(3104669) /Source="Nicolas_upshifts" /id="D1823" /incds=0 /nref=3 /ntot=85 /MaxReadThrough="3.18641" /MaxDrop="3.13207" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=66 /isTUend="FALSE" /label="downshifts" downshifts complement(3104734) /Source="Nicolas_upshifts" /id="D1824" /incds=1 /nref=94 /ntot=239 /MaxReadThrough="4.11808" /MaxDrop="4.31508" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(3105854..3105931) /Source="Nicolas_S_feature" /locus_tag="new_3621540_3621617_c" /HighExp="LBGstat, Lbstat, M0t90, Cold, M/G, GM 10, GM 25, GM 15, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1344" downshifts complement(3105857) /Source="Nicolas_upshifts" /id="D1825" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="6.36185" /MaxDrop="3.35962" /score="-9.46264764" /energy="-7.1" /TU="U2760,U2761,U2762" /idTUdmin="U2762" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(3105932..3106270) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16030230" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16030230; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein fragment; C-terminal part of swrAA" /db_xref="GOA:O32266" /db_xref="InterPro:IPR035388" /db_xref="PSEUDO:CAB15540.1" /db_xref="SubtiList:BG14160" /db_xref="UniProtKB/Swiss-Prot:O32266" /translation="MCVKKKYYELVEQLKDRTQDVTFSATKALSLLMLFSRYLVNYTN VESVNDINEECAKHYFNYLMKNHKRLGINLTDIKRSMHLISGLLDVDVNHYLKDFSLS NVTLWMTQER*" /label="swrAAc CDS" gene complement(3105932..3106270) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /pseudo /label="swrAAc gene" CDS complement(3106245..3106361) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein; N-terminal part of swrAA" /db_xref="PSEUDO:CAX52697.1" /translation="MLVSTPVLLLILARAYLYKENGGSQLKRASIVREKKIL*" /label="swrAAn CDS" gene complement(3106245..3106361) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /pseudo /label="swrAAn gene" S_feature complement(3106362..3106451) /Source="Nicolas_S_feature" /locus_tag="new_3622048_3622137_c" /HighExp="LBGstat, M0t90, Cold, Lbstat, GM 25, Gly, nit, GM 15, GM 10, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1345" promotor_-10 complement(3106433..3106451) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3106451) /Source="Nicolas_upshifts" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3106453..3106533) /Source="Nicolas_S_feature" /locus_tag="new_3622139_3622219_c" /HighExp="LBGstat, Lbstat, Cold, M0t90, GM 25, nit, Gly, M/G, MG 150, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigGF" /TUshortPSig="0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1346" promotor_-35 complement(3106465..3106470) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3106519..3106537) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3106533) /Source="Nicolas_upshifts" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3106551..3106558) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3106670..3108112) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14526016, 17557826, 27342562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526016, 17557826, 27342562; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="PDZ-containing carboxyl-terminal protease processing protease [Zn(II)]" /protein_id="NP_391404.1" /db_xref="EnsemblGenomes-Gn:BSU35240" /db_xref="EnsemblGenomes-Tr:CAB15541" /db_xref="GOA:O35002" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="PDB:4C2C" /db_xref="PDB:4C2D" /db_xref="PDB:4C2E" /db_xref="PDB:4C2F" /db_xref="PDB:4C2G" /db_xref="PDB:4C2H" /db_xref="SubtiList:BG14110" /db_xref="UniProtKB/Swiss-Prot:O35002" /translation="MNQKIMAVIAAGSMLFGGAGVYAGINLLEMDKPQTAAVPATAQA DSERDKAMDKIEKAYELISNEYVEKVDREKLLEGAIQGMLSTLNDPYSVYMDKQTAKQ FSDSLDSSFEGIGAEVGMEDGKIIIVSPFKKSPAEKAGLKPNDEIISINGESMAGKDL NHAVLKIRGKKGSSVSMKIQRPGTKKQLSFRIKRAEIPLETVFASEKKVQGHSVGYIA ISTFSEHTAEDFAKALRELEKKEIEGLVIDVRGNPGGYLQSVEEILKHFVTKDQPYIQ IAERNGDKKRYFSTLTHKKAYPVNVITDKGSASASEILAGALKEAGHYDVVGDTSFGK GTVQQAVPMGDGSNIKLTLYKWLTPNGNWIHKKGIEPTIAIKQPDYFSAGPLQLKEPL KVDMNNEDVKHAQVLLKGLSFDPGREDGYFSKDMKKAVMAFQDQNKLNKTGVIDTRTA ETLNQQIEKKKSDEKNDLQLQTALKSLFVN*" /label="ctpB CDS" gene complement(3106670..3108112) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /label="ctpB gene" downshifts complement(3106759) /Source="Nicolas_upshifts" /id="D1826" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="3.56833" /MaxDrop="3.1636" /score="0.562448109" /energy="-11.6" /TU="U2762" /idTUdmin="U2762" /TUdmin="-1122" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3108158..3108169) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3108169) /Source="Nicolas_upshifts" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3108184..3108190) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3108252..3109142) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 23855774, 23869552" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 23855774, 23869552; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-division ABC transporter" /protein_id="NP_391405.1" /db_xref="EnsemblGenomes-Gn:BSU35250" /db_xref="EnsemblGenomes-Tr:CAB15542" /db_xref="GOA:O34876" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR004513" /db_xref="SubtiList:BG12591" /db_xref="UniProtKB/Swiss-Prot:O34876" /translation="MIKILGRHLRESFKSLGRNTWMTFASISAVTVTLILVGVFLVIM LNLNNMATNAEKQVEIKVLIDLTADQKAQDKLQNDIKELKGIQSVTFSSKEKELDQLV DSFGDSGKSLTMKDQENPLNDAFVVKTTDPHDTPNVAKKIEKMDHVYKVTYGKEEVSR LFKVVGVSRNIGIALIIGLVFTAMFLISNTIKITIFARRKEIEIMKLVGATNWFIRWP FFLEGLLLGVFGSVIPIALVLSTYQYVIGWVVPKVQGSFVSLLPYNPFVFQVSLVLIA IGAVIGVWGSLTSIRKFLRV*" /label="ftsX CDS" gene complement(3108252..3109142) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /label="ftsX gene" downshifts complement(3108269) /Source="Nicolas_upshifts" /id="D1827" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="3.3693" /MaxDrop="6.15417" /score="15.3496791" /energy="-14.6" /TU="U2763" /idTUdmin="U2763" /TUdmin="-102" /isTUend="FALSE" /label="downshifts" CDS complement(3109135..3109821) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division signal transducer (ATP-binding protein)" /protein_id="NP_391406.1" /db_xref="EnsemblGenomes-Gn:BSU35260" /db_xref="EnsemblGenomes-Tr:CAB15543" /db_xref="GOA:O34814" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005286" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12590" /db_xref="UniProtKB/Swiss-Prot:O34814" /translation="MIEMKEVYKAYPNGVKALNGISVTIHPGEFVYVVGPSGAGKSTF IKMIYREEKPTKGQILINHKDLATIKEKEIPFVRRKIGVVFQDFKLLPKLTVFENVAF ALEVIGEQPSVIKKRVLEVLDLVQLKHKARQFPDQLSGGEQQRVSIARSIVNNPDVVI ADEPTGNLDPDTSWEVMKTLEEINNRGTTVVMATHNKEIVNTMKKRVIAIEDGIIVRD ESRGEYGSYD*" /label="ftsE CDS" gene complement(3109135..3109821) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /label="ftsE gene" S_feature complement(3109822..3109954) /Source="Nicolas_S_feature" /locus_tag="new_3625508_3625640_c" /HighExp="Cold, UNK1, MG-0.2, MG 15, MG-0.1, C30, MG 25, MG 10, M9-exp, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.998" /label="S1347" promotor_-10 complement(3109944..3109963) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3109954) /Source="Nicolas_upshifts" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3109978..3109981) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3110055..3110393) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10473570, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10473570, 19222757; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome c551" /protein_id="NP_391407.1" /db_xref="EnsemblGenomes-Gn:BSU35270" /db_xref="EnsemblGenomes-Tr:CAB15544" /db_xref="GOA:O34594" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG12574" /db_xref="UniProtKB/Swiss-Prot:O34594" /translation="MKSKLSILMIGFALSVLLAACGSNDAKEEKTDTGSKTEATASEG EELYQQSCVGCHGKDLEGVSGPNLQEVGGKYDEHKIESIIKNGRGNMPKGLVDDNEAA VIAKWLSEKK*" /label="cccB CDS" gene complement(3110055..3110393) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /label="cccB gene" downshifts complement(3110056) /Source="Nicolas_upshifts" /id="D1828" /incds=0 /nref=192 /ntot=265 /MaxReadThrough="3.58546" /MaxDrop="6.88513" /score="18.0901387" /energy="-16.8" /TU="U2764" /idTUdmin="U2765" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3110420..3110439) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3110433) /Source="Nicolas_upshifts" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="upshifts" CDS complement(3110442..3111326) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10473570, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391408.2" /db_xref="EnsemblGenomes-Gn:BSU35280" /db_xref="EnsemblGenomes-Tr:CAB15545" /db_xref="GOA:O34792" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG14109" /db_xref="UniProtKB/Swiss-Prot:O34792" /translation="MLSESIGRNGGYMMDVRNKTLWILRDYVYILIGAAITAVSFNVF LLPNKIAAGGVSGISTILQSYGFEAAYVQWIINIPLFIAGVILLGGKFGLKTLAGSVF LPLVVFLTRDIQPATHHELLAAIFGGVGIGIGIGIVYLGKGSTGGTALAAQIIHKYSG LSLGKCLAIIDGMIVVTAMIVFNIEQGLYAMLGVYVSSKTIDVVQVGFNRSKMALIIT KQEQAVKEAVLQKIDRGVTKISAVGGYTDDDRPILMCVVGQTEFTKLKQIVKQIDESA FVIVADASEVLGEGFKRA*" /label="yvjA CDS" gene complement(3110442..3111326) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /label="yvjA gene" promotor_-35 complement(3110453..3110460) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" promotor_-10 complement(3111314..3111333) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3111335) /Source="Nicolas_upshifts" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="upshifts" promotor_-35 complement(3111348..3111355) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" CDS join(complement(3112483..3112554), complement(3111453..3112481)) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /experiment="publication(s) with functional evidences, PMID:1408743, 9696765, 9882663" /ribosomal_slippage /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1408743, 9696765, 9882663; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 2" /protein_id="NP_391409.1" /db_xref="EnsemblGenomes-Gn:BSU35290" /db_xref="EnsemblGenomes-Tr:CAB15546" /db_xref="GOA:P28367" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004374" /db_xref="InterPro:IPR005139" /db_xref="InterPro:IPR020853" /db_xref="SubtiList:BG10742" /db_xref="UniProtKB/Swiss-Prot:P28367" /translation="MELSEIRAELENMASRLADFRGSLDLESKEARIAELDEQMADPE FWNDQQKAQTVINEANGLKDYVNSYKKLNESHEELQMTHDLLKEEPDTDLQLELEKEL KSLTKEFNEFELQLLLSEPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWGERRGF KVETLDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFVS CEVMPEFNDEIDIDIRTEDIKVDTYRASGAGGQHVNTTDSAVRITHLPTNVVVTCQTE RSQIKNRERAMKMLKAKLYQRRIEEQQAELDEIRGEQKEIGWGSQIRSYVFHPYSMVK DHRTNTEMGNVQAVMDGDIDTFIDAYLRSKLS*" /label="prfB CDS" gene complement(3111453..3112554) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /label="prfB gene" downshifts complement(3111469) /Source="Nicolas_upshifts" /id="D1829" /incds=0 /nref=193 /ntot=257 /MaxReadThrough="2.78016" /MaxDrop="6.41678" /score="27.1588259" /energy="-9.8" /TU="NA" /idTUdmin="U2766" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(3112555..3112623) /Source="Nicolas_S_feature" /locus_tag="new_3628241_3628309_c" /HighExp="Etha, Sw, Cold, BC, G150, BI, dia15, Mt0, LBGtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1348" CDS complement(3112624..3115149) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="translocase binding subunit (ATPase)" /protein_id="NP_391410.1" /db_xref="EnsemblGenomes-Gn:BSU35300" /db_xref="EnsemblGenomes-Tr:CAB15547" /db_xref="GOA:P28366" /db_xref="InterPro:IPR000185" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR011115" /db_xref="InterPro:IPR011116" /db_xref="InterPro:IPR011130" /db_xref="InterPro:IPR014018" /db_xref="InterPro:IPR020937" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036266" /db_xref="InterPro:IPR036670" /db_xref="PDB:1M6N" /db_xref="PDB:1M74" /db_xref="PDB:1TF2" /db_xref="PDB:1TF5" /db_xref="PDB:2IBM" /db_xref="PDB:3DL8" /db_xref="PDB:3IQM" /db_xref="PDB:3IQY" /db_xref="PDB:3JV2" /db_xref="PDB:5EUL" /db_xref="SubtiList:BG10741" /db_xref="UniProtKB/Swiss-Prot:P28366" /translation="MLGILNKMFDPTKRTLNRYEKIANDIDAIRGDYENLSDDALKHK TIEFKERLEKGATTDDLLVEAFAVVREASRRVTGMFPFKVQLMGGVALHDGNIAEMKT GEGKTLTSTLPVYLNALTGKGVHVVTVNEYLASRDAEQMGKIFEFLGLTVGLNLNSMS KDEKREAYAADITYSTNNELGFDYLRDNMVLYKEQMVQRPLHFAVIDEVDSILIDEAR TPLIISGQAAKSTKLYVQANAFVRTLKAEKDYTYDIKTKAVQLTEEGMTKAEKAFGID NLFDVKHVALNHHINQALKAHVAMQKDVDYVVEDGQVVIVDSFTGRLMKGRRYSEGLH QAIEAKEGLEIQNESMTLATITFQNYFRMYEKLAGMTGTAKTEEEEFRNIYNMQVVTI PTNRPVVRDDRPDLIYRTMEGKFKAVAEDVAQRYMTGQPVLVGTVAVETSELISKLLK NKGIPHQVLNAKNHEREAQIIEEAGQKGAVTIATNMAGRGTDIKLGEGVKELGGLAVV GTERHESRRIDNQLRGRSGRQGDPGITQFYLSMEDELMRRFGAERTMAMLDRFGMDDS TPIQSKMVSRAVESSQKRVEGNNFDSRKQLLQYDDVLRQQREVIYKQRFEVIDSENLR EIVENMIKSSLERAIAAYTPREELPEEWKLDGLVDLINTTYLDEGALEKSDIFGKEPD EMLELIMDRIITKYNEKEEQFGKEQMREFEKVIVLRAVDSKWMDHIDAMDQLRQGIHL RAYAQTNPLREYQMEGFAMFEHMIESIEDEVAKFVMKAEIENNLEREEVVQGQTTAHQ PQEGDDNKKAKKAPVRKVVDIGRNAPCHCGSGKKYKNCCGRTE*" /label="secA CDS" gene complement(3112624..3115149) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /label="secA gene" S_feature complement(3115150..3115230) /Source="Nicolas_S_feature" /locus_tag="new_3630836_3630916_c" /HighExp="Etha, M9-stat, T0.30H, B60, dia5, Cold, dia15, Lbexp, Salt, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1349" misc_feature complement(3115220..3115239) /Source="Nicolas_upshift_promotors" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3115230) /Source="Nicolas_upshifts" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3115317..3115886) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome-associated sigma 54 modulation protein;ribosome dimerisation factor" /protein_id="NP_391411.1" /db_xref="EnsemblGenomes-Gn:BSU35310" /db_xref="EnsemblGenomes-Tr:CAB15548" /db_xref="GOA:P28368" /db_xref="InterPro:IPR003489" /db_xref="InterPro:IPR032528" /db_xref="InterPro:IPR034694" /db_xref="InterPro:IPR036567" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10740" /db_xref="UniProtKB/Swiss-Prot:P28368" /translation="MNYNIRGENIEVTPALKDHVERKIGKLERYFDHSVDADVNVNLK FYNDKESKVEVTIPMTDLALRSEVHNEDMYNAIDLATNKLERQIRKHKTKVNRKFREQ GSPKYLLANGLGSDTDIAVQDDIEEEESLDIVRQKRFNLKPMDSEEAILQMNMLGHNF FVFTNAETNLTNVVYRRNDGKYGLIEPTE*" /label="hpf CDS" gene complement(3115317..3115886) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /label="hpf gene" downshifts complement(3115325) /Source="Nicolas_upshifts" /id="D1830" /incds=0 /nref=78 /ntot=209 /MaxReadThrough="8.66806" /MaxDrop="4.7023" /score="29.9030506" /energy="-12.2" /TU="U2768,U2769,U2770,U2773" /idTUdmin="U2773" /TUdmin="-74" /isTUend="FALSE" /label="downshifts" promotor_-35 3115853..3115859 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3115872..3115891 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3115879 /Source="Nicolas_upshifts" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3115913..3115931) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3115921) /Source="Nicolas_upshifts" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3115923..3116043) /Source="Nicolas_S_feature" /locus_tag="new_3631609_3631729_c" /HighExp="C30, M0t90, S4, Lbstat, S5, M40t90, Glucon, Gly, C90, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigD, SigD" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1350" promotor_-35 complement(3115943..3115951) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3116027..3116045) /Source="Nicolas_upshift_promotors" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3116043) /Source="Nicolas_upshifts" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3116061..3116066) /Source="Nicolas_upshift_promotors" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3116077..3116454) /gene="yvzG" /locus_tag="BSU_35319" /old_locus_tag="BSU35319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097791.1" /db_xref="EnsemblGenomes-Gn:BSU35319" /db_xref="EnsemblGenomes-Tr:CAX52698" /db_xref="UniProtKB/Swiss-Prot:C0H3R9" /translation="MKSIEDYTLLSAYYHLLFTIEEGLCYLIEAEENLSKTEGDRIYQ DLIQAFFYLDSTHSTLLFIMDSRCAEICVKAFDQIFAEFDQLVSFSFPSHEFCEYLKE HFLIHYRKWMLSIHQCMEPFLIN*" /label="yvzG CDS" gene complement(3116077..3116454) /gene="yvzG" /locus_tag="BSU_35319" /old_locus_tag="BSU35319" /label="yvzG gene" CDS complement(3116464..3116805) /gene="fliT" /locus_tag="BSU_35320" /old_locus_tag="BSU35320" /function="16.3: Control" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16952964; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar assembly protein FliT involved in control of flagella expression" /protein_id="NP_391412.1" /db_xref="EnsemblGenomes-Gn:BSU35320" /db_xref="EnsemblGenomes-Tr:CAB15549" /db_xref="GOA:P39740" /db_xref="SubtiList:BG10923" /db_xref="UniProtKB/Swiss-Prot:P39740" /translation="MNNIDQLYTETKSMLSHIQNTPESDELLKQIEDFVATRSELIQE ISLPLSEEERKQMKLILTWDQLIVKEMERLKQSIATELQQMKRKRVMHTTYLNPYNNI TIDGTYYDKRK*" /label="fliT CDS" gene complement(3116464..3116805) /gene="fliT" /locus_tag="BSU_35320" /old_locus_tag="BSU35320" /label="fliT gene" CDS complement(3116802..3117203) /gene="fliS" /locus_tag="BSU_35330" /old_locus_tag="BSU35330" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16806204, 16936039, 20534509, 23144244, 23874669; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar assembly protein FliS" /protein_id="NP_391413.1" /db_xref="EnsemblGenomes-Gn:BSU35330" /db_xref="EnsemblGenomes-Tr:CAB15550" /db_xref="GOA:P39739" /db_xref="InterPro:IPR003713" /db_xref="InterPro:IPR036584" /db_xref="PDB:1VH6" /db_xref="SubtiList:BG10922" /db_xref="UniProtKB/Swiss-Prot:P39739" /translation="MAIQNPYTAYQQNSVNTATPGELTLMLYNGCLKFIRLAAQAIEN DDMERKNENLIKAQNIIQELNFTLNRNIELSASMGAMYDYMYRRLVQANIKNDTGMLA EVEGYVTDFRDAWKQAIQSERKDRHGSGGIA*" /label="fliS CDS" gene complement(3116802..3117203) /gene="fliS" /locus_tag="BSU_35330" /old_locus_tag="BSU35330" /label="fliS gene" CDS complement(3117225..3118721) /gene="fliD" /locus_tag="BSU_35340" /old_locus_tag="BSU35340" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9648743, 12354229, 24296669, 25355936; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar hook-associated capping protein 2 (HAP2)" /protein_id="NP_391414.1" /db_xref="EnsemblGenomes-Gn:BSU35340" /db_xref="EnsemblGenomes-Tr:CAB15551" /db_xref="GOA:P39738" /db_xref="InterPro:IPR003481" /db_xref="InterPro:IPR010809" /db_xref="InterPro:IPR010810" /db_xref="SubtiList:BG10921" /db_xref="UniProtKB/Swiss-Prot:P39738" /translation="MVTRITGLASGMDIDDIVSKLMQTERAPLDKLTQKKQTLEWQRD SYREVNSKIKELQDYMSKNTLTYPSTYQSKTVTSSNESVLTATGSVSAPNSSSTVEVA SLATAATYKANNYTGYTQGDYNLAFNVVAPGETTAKTVNISVTSADTIDNVISKLNSS DLGVSAFKDKIWNGTEYVETIAFSSKATGAGGSIQAADSATADFMSGQLGFSLDADNK LTAYKEGTNAKVTINGFEMEKLTNNFTVNGVTYSIKNTTAATGPVTTSVSTDVDGIYN QIKEFVDKYNELVDSLNEKLKEEKYRDYTPLTSEQKEAMSDKEVELWEEKAKSGLLRN DSSISTGTNQMRTDFYTQVNADGKTYQLTEFGITTSSAYQLRGHLEINEEKLKAKIAE DPQGVANLFTSGTNDSNYSDKGIMKRITNTLRSTVKSIEAKAGNSTMGASSYSIGKNL NSISTEITDMQDRLNTIENRYYSKFSAMDSAIQKMNEQASYLSQLLVQ*" /label="fliD CDS" gene complement(3117225..3118721) /gene="fliD" /locus_tag="BSU_35340" /old_locus_tag="BSU35340" /label="fliD gene" CDS complement(3118739..3119068) /gene="yvyC" /locus_tag="BSU_35350" /old_locus_tag="BSU35350" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 19455708; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative flagellar protein of unknown function" /protein_id="NP_391415.1" /db_xref="EnsemblGenomes-Gn:BSU35350" /db_xref="EnsemblGenomes-Tr:CAB15552" /db_xref="InterPro:IPR005186" /db_xref="InterPro:IPR035924" /db_xref="PDB:2HC5" /db_xref="SubtiList:BG10920" /db_xref="UniProtKB/Swiss-Prot:P39737" /translation="MNIERLTTLQPVWDRYDTQIHNQKDNDNEVPVHQVSYTNLAEMV GEMNKLLEPSQVHLKFELHDKLNEYYVKVIEDSTNEVIREIPPKRWLDFYAAMTEFLG LFVDEKK*" /label="yvyC CDS" gene complement(3118739..3119068) /gene="yvyC" /locus_tag="BSU_35350" /old_locus_tag="BSU35350" /label="yvyC gene" downshifts 3119065 /Source="Nicolas_upshifts" /id="D1831" /incds=0 /nref=33 /ntot=140 /MaxReadThrough="2.74277" /MaxDrop="4.24086" /score="8.30527041" /energy="-10.1" /TU="NA" /idTUdmin="U2774" /TUdmin="-3062" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3119090..3119108) /Source="Nicolas_upshift_promotors" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3119105) /Source="Nicolas_upshifts" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3119107..3119211) /Source="Nicolas_S_feature" /locus_tag="new_3634793_3634897_c" /HighExp="Lbstat, Cold, Gly, S0, Glu, Pyr, M/G, M0t90, C30, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1351" promotor_-35 complement(3119122..3119129) /Source="Nicolas_upshift_promotors" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3119200..3119219) /Source="Nicolas_upshift_promotors" /id="U2771" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2693 /SigmaFactorBS="tcttttaatttaaatttctatctcctaatcattcctcatcct gtcactaactCATGATATAATAACCGGATTctccactaactttttataaatgtatttc c" /listShort="S1351, yvyC, fliD, fliS, fliT, yvzG" /listLong="S1350, yvyD, S1349, secA, S1348, prfB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3119211) /Source="Nicolas_upshifts" /id="U2771" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2693 /SigmaFactorBS="tcttttaatttaaatttctatctcctaatcattcctcatcct gtcactaactCATGATATAATAACCGGATTctccactaactttttataaatgtatttc c" /listShort="S1351, yvyC, fliD, fliS, fliT, yvzG" /listLong="S1350, yvyD, S1349, secA, S1348, prfB" /label="upshifts" CDS complement(3119301..3120215) /gene="hag" /locus_tag="BSU_35360" /old_locus_tag="BSU35360" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8045886, 9648743, 12730172, 14762011, 15342569, 22720735, 25355936, 28800172, 29124898" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045886, 9648743, 12730172, 14762011, 15342569, 22720735, 25355936, 28800172, 29124898; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellin protein" /protein_id="NP_391416.1" /db_xref="EnsemblGenomes-Gn:BSU35360" /db_xref="EnsemblGenomes-Tr:CAB15553" /db_xref="GOA:P02968" /db_xref="InterPro:IPR001029" /db_xref="InterPro:IPR001492" /db_xref="SubtiList:BG10655" /db_xref="UniProtKB/Swiss-Prot:P02968" /translation="MRINHNIAALNTLNRLSSNNSASQKNMEKLSSGLRINRAGDDAA GLAISEKMRGQIRGLEMASKNSQDGISLIQTAEGALTETHAILQRVRELVVQAGNTGT QDKATDLQSIQDEISALTDEIDGISNRTEFNGKKLLDGTYKVDTATPANQKNLVFQIG ANATQQISVNIEDMGADALGIKEADGSIAALHSVNDLDVTKFADNAADTADIGFDAQL KVVDEAINQVSSQRAKLGAVQNRLEHTINNLSASGENLTAAESRIRDVDMAKEMSEFT KNNILSQASQAMLAQANQQPQNVLQLLR*" /label="hag CDS" gene complement(3119301..3120215) /gene="hag" /locus_tag="BSU_35360" /old_locus_tag="BSU35360" /label="hag gene" downshifts complement(3119321) /Source="Nicolas_upshifts" /id="D1832" /incds=0 /nref=165 /ntot=233 /MaxReadThrough="5.58531" /MaxDrop="7.10921" /score="11.6997504" /energy="-13.1" /TU="U2773" /idTUdmin="U2775" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" S_feature complement(3120216..3120324) /Source="Nicolas_S_feature" /locus_tag="new_3635902_3636010_c" /HighExp="T2.0H, Glucon, M0t90, T2.30H, GM 15, T-0.40H, GM 10, T1.0H, T-1.10H, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1352" promotor_-35 3120282..3120283 /Source="Nicolas_upshift_promotors" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3120292..3120306 /Source="Nicolas_upshift_promotors" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3120301 /Source="Nicolas_upshifts" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3120303..3120321) /Source="Nicolas_upshift_promotors" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" /label="promotor_-10" upshifts complement(3120324) /Source="Nicolas_upshifts" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" /label="upshifts" promotor_-35 complement(3120334..3120341) /Source="Nicolas_upshift_promotors" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" /label="promotor_-35" CDS complement(3120360..3120584) /gene="csrA" /locus_tag="BSU_35370" /old_locus_tag="BSU35370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8982093, 17555441, 21895793, 23144244, 27516547" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8982093, 17555441, 21895793, 23144244, 27516547; Product type r: regulator" /codon_start=1 /transl_table=11 /product="carbon storage regulator" /protein_id="NP_391417.1" /db_xref="EnsemblGenomes-Gn:BSU35370" /db_xref="EnsemblGenomes-Tr:CAB15554" /db_xref="GOA:P33911" /db_xref="InterPro:IPR003751" /db_xref="InterPro:IPR036107" /db_xref="PDB:1T3O" /db_xref="SubtiList:BG10654" /db_xref="UniProtKB/Swiss-Prot:P33911" /translation="MLVLSRKINEAIQIGADIEVKVIAVEGDQVKLGIDAPKHIDIHR KEIYLTIQEENNRAAALSSDVISALSSQKK*" /label="csrA CDS" gene complement(3120360..3120584) /gene="csrA" /locus_tag="BSU_35370" /old_locus_tag="BSU35370" /label="csrA gene" downshifts complement(3120399) /Source="Nicolas_upshifts" /id="D1833" /incds=0 /nref=22 /ntot=171 /MaxReadThrough="2.28652" /MaxDrop="3.46262" /score="31.5820557" /energy="-9.2" /TU="NA" /idTUdmin="U2775" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3120578..3121009) /gene="fliW" /locus_tag="BSU_35380" /old_locus_tag="BSU35380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15033535, 16936039, 21895793, 27516547" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15033535, 16936039, 21895793, 27516547; Product type f: factor" /codon_start=1 /transl_table=11 /product="assembly factor of the flagellum" /protein_id="NP_391418.1" /db_xref="EnsemblGenomes-Gn:BSU35380" /db_xref="EnsemblGenomes-Tr:CAB15555" /db_xref="GOA:P96503" /db_xref="InterPro:IPR003775" /db_xref="InterPro:IPR024046" /db_xref="SubtiList:BG12451" /db_xref="UniProtKB/Swiss-Prot:P96503" /translation="MIIHTKYHGQMNIKEEQIILFESGIPGFLEEKQFVILPLSEDSP FVALQSVTSENLAFIVVSPFIFFKNYEFDLDESTAELLDIDNIQDVEVMTILTMAEPF EKSTANLLAPIIVNRKNMMAKQVVLHDSSYTTKHPIGGESC*" /label="fliW CDS" gene complement(3120578..3121009) /gene="fliW" /locus_tag="BSU_35380" /old_locus_tag="BSU35380" /label="fliW gene" CDS complement(3121030..3121605) /gene="yviE" /locus_tag="BSU_35390" /old_locus_tag="BSU35390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391419.1" /db_xref="EnsemblGenomes-Gn:BSU35390" /db_xref="EnsemblGenomes-Tr:CAB15556" /db_xref="SubtiList:BG12450" /db_xref="UniProtKB/Swiss-Prot:P96502" /translation="MQIPRLIMHSVQGKIGLTTTPASLKMEQPQADLEIEQPSAEMEI SVTPGKLTIDQTQAWEELDRKHVFKRIEEAAQQGHEDVMEGIARTAEEGDELMKIENK GNPIASQARRNSEMHQIQLGENYAPSLSRVKIQYTPSQLDVQITPRKPVIQAEPHKPI VEYTPGNVKVDMLQYPDLNIDVEYPKESPEK*" /label="yviE CDS" gene complement(3121030..3121605) /gene="yviE" /locus_tag="BSU_35390" /old_locus_tag="BSU35390" /label="yviE gene" CDS complement(3121652..3122548) /gene="flgL" /locus_tag="BSU_35400" /old_locus_tag="BSU35400" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2407720, 15033535, 17438286, 23874669, 24296669, 24706744; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar hook-filament junction protein" /protein_id="NP_391420.1" /db_xref="EnsemblGenomes-Gn:BSU35400" /db_xref="EnsemblGenomes-Tr:CAB15557" /db_xref="GOA:P96501" /db_xref="InterPro:IPR001029" /db_xref="InterPro:IPR013384" /db_xref="SubtiList:BG11936" /db_xref="UniProtKB/Swiss-Prot:P96501" /translation="MRVTQGMIQQNSLRYIGSSYSKLDKLQSQISSGKKISKASDDPV VAMKSLKYNTQLSQVQQYKSNASQAFTWLENTETNITEGIDILSKVRELAVEAQNDTN GEPERQAIGVEVKQLKEQLLNIANTQVNGRYIFNGTNSDKPPVTDNGDGTYTISDTAD VVVNISNNMSLKVNSDPKSAFGGTSESGQNVFEMLDSFEKALNSGSLDGMDSVLNDID HFSDGMSAERSDLGARYNRLELVNTRLSAQEETATKVLSDNEDVELEEVITEFIAQQS VHRATLAVNAQIVQPTLIDFLK*" /label="flgL CDS" gene complement(3121652..3122548) /gene="flgL" /locus_tag="BSU_35400" /old_locus_tag="BSU35400" /label="flgL gene" downshifts complement(3121675) /Source="Nicolas_upshifts" /id="D1834" /incds=0 /nref=112 /ntot=251 /MaxReadThrough="5.50861" /MaxDrop="3.8234" /score="0.376587888" /energy="-4.8" /TU="U2775,U2776,U2777" /idTUdmin="U2777" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" misc_feature 3121964..3121967 /Source="Nicolas_upshift_promotors" /id="U2774" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.97902097902098" /psig="0.000999000999001" /xcortree=54 /SigmaFactorBS="actgtccatgccatctagcgaaccagaatttagtgctttctc aaaagaatcAAGCatttcaaatacattctgcccgctttcagaagtgcctccaaaagct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3121973 /Source="Nicolas_upshifts" /id="U2774" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.97902097902098" /psig="0.000999000999001" /xcortree=54 /SigmaFactorBS="actgtccatgccatctagcgaaccagaatttagtgctttctc aaaagaatcAAGCatttcaaatacattctgcccgctttcagaagtgcctccaaaagct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3122559..3124082) /gene="flgK" /locus_tag="BSU_35410" /old_locus_tag="BSU35410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2407720, 15033535, 17438286, 23874669, 24296669, 24706744; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar hook-filament junction" /protein_id="NP_391421.1" /db_xref="EnsemblGenomes-Gn:BSU35410" /db_xref="EnsemblGenomes-Tr:CAB15558" /db_xref="GOA:P39810" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR002371" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10401" /db_xref="UniProtKB/Swiss-Prot:P39810" /translation="MTSTFMGLETARRALSAQQAALSTTANNVANANTDGYTRQRVSL EATDYFPAVSKNAEKTAGQMGTGVQGKSVERIRDIFLDYQYRLQNNSAGYYDTKAKAL SQMEGVLNETDDSGLNSVLNSFWNSLQELSNNTNEESARSVVARKGQAVAETFNYISE SLTNVQSNLKAELNTTVLDVNSLLSQLNSLNKQIAQVEPVGLLPNGLYDQRDLLIDKL SSMVDIKVSYNKSGGNALASAEGTVSIEILDKNKQSLGTVLDGKNYEVSELAANYDNE TGLVSSISIGDTAVQAESFSSKGSLLGFIESYGYITADGQEKGVYPEMLSDLDNMALE FAKAFNEVHRNGVTKSGEQGGDFFDFTGGETEPAKGAAGKIKVADSIIDSKGANIAFS LTGAANDNANATKLANVLTGKITINGKETSVLDYYAGLIGELGIEAQEANRLASNTET QLNDADINRQQMSAVSLDEEMTNMIQFQHAYNAAARMVTLQDELLDKVINGMGVGGR* " /label="flgK CDS" gene complement(3122559..3124082) /gene="flgK" /locus_tag="BSU_35410" /old_locus_tag="BSU35410" /label="flgK gene" CDS complement(3124101..3124583) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:24706744" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24706744; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for flagellar based motility" /protein_id="NP_391422.1" /db_xref="EnsemblGenomes-Gn:BSU35420" /db_xref="EnsemblGenomes-Tr:CAB15559" /db_xref="GOA:P39808" /db_xref="InterPro:IPR007809" /db_xref="InterPro:IPR036679" /db_xref="SubtiList:BG10400" /db_xref="UniProtKB/Swiss-Prot:P39808" /translation="MSAKAIIEQLKRLCVLHEHLLTLSEEKTEALKAGKTKELSNILT KEQKYIQAITQTEDDRIKTTSAFLGYSENNTISACIAKTSGSEKEELEQLYESLSQVL GRLKKVNEMNRQLTRDALQFISISYDMLVPKENNFNYSKSIKAELPKSSKMKLFDSKA *" /label="flgN CDS" gene complement(3124101..3124583) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /label="flgN gene" CDS complement(3124599..3124865) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma factor repressor of sigma(D)-dependent transcription" /protein_id="NP_391423.1" /db_xref="EnsemblGenomes-Gn:BSU35430" /db_xref="EnsemblGenomes-Tr:CAB15560" /db_xref="GOA:P39809" /db_xref="InterPro:IPR007412" /db_xref="InterPro:IPR031316" /db_xref="InterPro:IPR035890" /db_xref="SubtiList:BG10399" /db_xref="UniProtKB/Swiss-Prot:P39809" /translation="MKINQFGTQSVNPYQKNYDKQAVQKTVAQPQDKIEISSQAKEMQ HASDAVTGSRQEKIAQLKAQIENGSYKVDANHIAKNMINFYKKQ*" /label="flgM CDS" gene complement(3124599..3124865) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /label="flgM gene" S_feature complement(3124866..3124945) /Source="Nicolas_S_feature" /locus_tag="new_3640552_3640631_c" /HighExp="T0.30H, Cold, C90, T-5.40H, T-4.40H, GM 150, T-2.40H, GM 45, S2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1353" CDS complement(3124946..3125365) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696775; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of flagella formation" /protein_id="NP_391424.1" /db_xref="EnsemblGenomes-Gn:BSU35440" /db_xref="EnsemblGenomes-Tr:CAB15561" /db_xref="GOA:P39807" /db_xref="InterPro:IPR022258" /db_xref="SubtiList:BG10398" /db_xref="UniProtKB/Swiss-Prot:P39807" /translation="MGELANCPKCNALFLKTKLQTVCQACIKEEEKSFETVYKFLRKQ ENRQSTLSRITEETGVEEELILKFIRQKRIQITHLPNLAYPCERCGTSIREGKFCKAC QSDIKDQMDHLNHEDALKIEKENSKKDTYYAYNTKNS*" /label="yvyF CDS" gene complement(3124946..3125365) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /label="yvyF gene" promotor_-10 complement(3125404..3125422) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3125415) /Source="Nicolas_upshifts" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3125436..3125443) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3125439..3126161) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 28618091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the DNA transport apparatus" /protein_id="NP_391425.2" /db_xref="EnsemblGenomes-Gn:BSU35450" /db_xref="EnsemblGenomes-Tr:CAB15562" /db_xref="GOA:P39147" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005222" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10397" /db_xref="UniProtKB/Swiss-Prot:P39147" /translation="MSNEAGGGIHKLICLLCDSQFSQDVTWRALFLLKPDEKVCYSCR SKLKKITGHICPLCGRPQSVHAVCRDCEVWRTRIRDSLLLRQNRSVYTYNDMMKETLS RFKFRGDAEIINAFKSDFSSTFSKVYPDKHFVLVPIPLSKEREEERGFNQAHLLAECL DRPSHHPLIRLNNEKQSKKKKTERLLSECIFDTKNNSAEGMNIILIDDLYTTGATLHF AARCLLEKGKAASVSSFTLIRS*" /label="comFC CDS" gene complement(3125439..3126161) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /label="comFC gene" CDS complement(3126125..3126421) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 25423369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 25423369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of competence, pole located" /protein_id="NP_391426.1" /db_xref="EnsemblGenomes-Gn:BSU35460" /db_xref="EnsemblGenomes-Tr:CAB15563" /db_xref="GOA:P39146" /db_xref="InterPro:IPR019657" /db_xref="PDB:4WAI" /db_xref="SubtiList:BG10396" /db_xref="UniProtKB/Swiss-Prot:P39146" /translation="MLVNSKEIVMKELLDRYMDQLHMACTCQVCQNDVLALSLNKVSP SYVTDFKKIAYTKAELVDKQKNTAMLVILAESAAVVSESPSDLCQTKQEEAFIN*" /label="comFB CDS" gene complement(3126125..3126421) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /label="comFB gene" promotor_-10 complement(3126447..3126466) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3126460) /Source="Nicolas_upshifts" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3126477..3126484) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3126481..3127872) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045895, 11359569, 12123453, 16009133, 21397556, 28559293" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045895, 11359569, 12123453, 16009133, 21397556, 28559293; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase competence protein" /protein_id="NP_391427.1" /db_xref="EnsemblGenomes-Gn:BSU35470" /db_xref="EnsemblGenomes-Tr:CAB15564" /db_xref="GOA:P39145" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10395" /db_xref="UniProtKB/Swiss-Prot:P39145" /translation="MNVPVEKNSSFSKELQQTLRSRHLLRTELSFSDEMIEWHIKNGY ITAENSISINKRRYRCNRCGQTDQRYFSFYHSSGKNKLYCRSCVMMGRVSEEVPLYSW KEENESNWKSIKLTWDGKLSSGQQKAANVLIEAISKKEELLIWAVCGAGKTEMLFPGI ESALNQGLRVCIATPRTDVVLELAPRLKAAFQGADISALYGGSDDKGRLSPLMISTTH QLLRYKDAIDVMIIDEVDAFPYSADQTLQFAVQKARKKNSTLVYLSATPPKELKRKAL NGQLHSVRIPARHHRKPLPEPRFVWCGNWKKKLNRNKIPPAVKRWIEFHVKEGRPVFL FVPSVSILEKAAACFKGVHCRTASVHAEDKHRKEKVQQFRDGQLDLLITTTILERGVT VPKVQTGVLGAESSIFTESALVQIAGRTGRHKEYADGDVIYFHFGKTKSMLDARKHIK EMNELAAKVECTD*" /label="comFA CDS" gene complement(3126481..3127872) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /label="comFA gene" promotor_-10 complement(3127886..3127905) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3127901) /Source="Nicolas_upshifts" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3127919..3127926) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3127978..3128823) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /EC_number="2.7.2.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit A" /protein_id="NP_391428.1" /db_xref="EnsemblGenomes-Gn:BSU35480" /db_xref="EnsemblGenomes-Tr:CAB15565" /db_xref="GOA:P32436" /db_xref="InterPro:IPR003797" /db_xref="PDB:3FYS" /db_xref="SubtiList:BG10394" /db_xref="UniProtKB/Swiss-Prot:P32436" /translation="MNIAVVTDSTAYIPKEMREQHQIHMIPLQVVFREETYREEIELD WKSFYEEVKKHNELPTTSQPPIGELVALYEELGKSYDAVISIHLSSGISGTFSSAAAA DSMVDNIDVYPFDSEISCLAQGFYALKAAELIKNGASSPEDIIKELEEMKKTVRAYFM VDDLAHLQRGGRLSSAQAFIGSLLKVKPILHFDNKVIVPFEKIRTRKKAISRIYELLD EDASKGLPMRAAVIHANREEEAAKIIEELSAKYPHVEFYNSYFGAVIGTHLGEGALGI CWCFK*" /label="fakBA CDS" gene complement(3127978..3128823) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /label="fakBA gene" downshifts complement(3127989) /Source="Nicolas_upshifts" /id="D1835" /incds=0 /nref=207 /ntot=249 /MaxReadThrough="2.43976" /MaxDrop="5.65998" /score="25.7738948" /energy="-9.9" /TU="NA" /idTUdmin="U2779" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3128240..3128247 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3128261..3128280 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3128271..3130003 /Source="Nicolas_S_feature" /locus_tag="new_3643957_3645689" /HighExp="C30, S2, C90, Pyr, T0.30H, GM 150, G/S, T-4.40H, T-3.40H, T1.30H" /AntisenseName="degU" /AntisenseCor="1.0564647169900101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1354" upshifts 3128271 /Source="Nicolas_upshifts" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3128850..3128869) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3128869) /Source="Nicolas_upshifts" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3128884..3128887) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3128921..3129610) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_391429.1" /db_xref="EnsemblGenomes-Gn:BSU35490" /db_xref="EnsemblGenomes-Tr:CAB15566" /db_xref="GOA:P13800" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10393" /db_xref="UniProtKB/Swiss-Prot:P13800" /translation="MTKVNIVIIDDHQLFREGVKRILDFEPTFEVVAEGDDGDEAARI VEHYHPDVVIMDINMPNVNGVEATKQLVELYPESKVIILSIHDDENYVTHALKTGARG YLLKEMDADTLIEAVKVVAEGGSYLHPKVTHNLVNEFRRLATSGVSAHPQHEVYPEIR RPLHILTRRECEVLQMLADGKSNRGIGESLFISEKTVKNHVSNILQKMNVNDRTQAVV VAIKNGWVEMR*" /label="degU CDS" gene complement(3128921..3129610) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /label="degU gene" downshifts complement(3128935) /Source="Nicolas_upshifts" /id="D1836" /incds=0 /nref=178 /ntot=235 /MaxReadThrough="5.12878" /MaxDrop="6.38336" /score="20.9249268" /energy="-12.8" /TU="U2781" /idTUdmin="U2779" /TUdmin="-946" /isTUend="FALSE" /label="downshifts" S_feature complement(3129611..3129692) /Source="Nicolas_S_feature" /locus_tag="new_3645297_3645378_c" /HighExp="M40t90, Lbtran, M0t90, LBGtran, G180, T3.0H, M40t45, C90, T3.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1355" CDS complement(3129693..3130850) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /EC_number="2.7.3.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [DegU]" /protein_id="NP_391430.1" /db_xref="EnsemblGenomes-Gn:BSU35500" /db_xref="EnsemblGenomes-Tr:CAB15567" /db_xref="GOA:P13799" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR008595" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR016381" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10392" /db_xref="UniProtKB/Swiss-Prot:P13799" /translation="MNKTKMDSKVLDSILMKMLKTVDGSKDEVFQIGEQSRQQYEQLV EELKQIKQQVYEVIELGDKLEVQTRHARNRLSEVSRNFHRFSEEEIRNAYEKAHKLQV ELTMIQQREKQLRERRDDLERRLLGLQEIIERSESLVSQITVVLNYLNQDLREVGLLL ADAQAKQDFGLRIIEAQEEERKRVSREIHDGPAQMLANVMMRSELIERIFRDRGAEDG FQEIKNLRQNVRNALYEVRRIIYDLRPMALDDLGLIPTLRKYLYTTEEYNGKVKIHFQ CIGETEDQRLAPQFEVALFRLAQEAVSNALKHSESEEITVKVEITKDFVILMIKDNGK GFDLKEAKEKKNKSFGLLGMKERVDLLEGTMTIDSKIGLGTFIMIKVPLSL*" /label="degS CDS" gene complement(3129693..3130850) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /label="degS gene" S_feature complement(3130851..3130978) /Source="Nicolas_S_feature" /locus_tag="new_3646537_3646664_c" /HighExp="T0.30H, Lbtran, M9-stat, T3.0H, T1.0H, HiOs, T1.30H, T2.30H, T3.30H, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1356" promotor_-35 3130898..3130901 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3130916..3130935 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3130927..3131013 /Source="Nicolas_S_feature" /locus_tag="new_3646613_3646699" /HighExp="UNK1, Cold, C30, Lbexp, MG 15, G135, G180, G150, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1357" upshifts 3130927 /Source="Nicolas_upshifts" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3130972..3130991) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3130978) /Source="Nicolas_upshifts" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3130995..3131003 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3131002..3131009) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3131015 /Source="Nicolas_upshifts" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3131017..3131025 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3131067..3131720 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11116084, 15103642, 21239490, 22404850; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative translation regulator" /protein_id="NP_391431.1" /db_xref="EnsemblGenomes-Gn:BSU35510" /db_xref="EnsemblGenomes-Tr:CAB15568" /db_xref="InterPro:IPR001498" /db_xref="InterPro:IPR015269" /db_xref="InterPro:IPR015796" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020569" /db_xref="InterPro:IPR023582" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR036956" /db_xref="SubtiList:BG11052" /db_xref="UniProtKB/Swiss-Prot:P32437" /translation="MLHSYFTVKEAGEHEIVIEKSRFICHLSRVSTEQEAQEFIQKIK KQHWNATHNCSAYVIGENDHIQKANDDGEPSGTAGVPMLEVLKKRRLKDTCAVVTRYF GGIKLGAGGLIRAYGKSVSEGLNHIGVVERKLMRIMHTSADYTWLGKIENELRESQFL LKEIHYSENVEFETYVEEKETNAFSEWMTELTNGKSDIKEGELTYLEKAVNHIKETE* " /label="yvyE CDS" gene 3131067..3131720 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /label="yvyE gene" S_feature complement(3131423..3132015) /Source="Nicolas_S_feature" /locus_tag="new_3647109_3647701_c" /HighExp="Etha, M9-stat, Gly, C30, B60, Salt, T0.30H, Sw, LoTm, S8" /AntisenseName="yvyE" /AntisenseCor="-0.139956338862644" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1358" CDS 3131720..3132895 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19099556, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19099556, 29107701; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain" /protein_id="NP_391432.1" /db_xref="EnsemblGenomes-Gn:BSU35520" /db_xref="EnsemblGenomes-Tr:CAB15569" /db_xref="GOA:P96499" /db_xref="InterPro:IPR004474" /db_xref="PDB:3NXH" /db_xref="SubtiList:BG12449" /db_xref="UniProtKB/Swiss-Prot:P96499" /translation="MAERVRVRVRKKKKSKRRKILKRIMLLFALALLVVVGLGGYKLY KTINAADESYDALSRGNKSNLRNEVVDMKKKPFSILFMGIEDYATKGQKGRSDSLIVV TLDPKNKTMKMLSIPRDTRVQLAGDTTGSKTKINAAYSKGGKDETVETVENFLQIPID KYVTVDFDGFKDVINEVGGIDVDVPFDFDEKSDVDESKRIYFKKGEMHLNGEEALAYA RMRKQDKRGDFGRNDRQKQILNALIDRMSSASNIAKIDKIAEKASENVETNIRITEGL ALQQIYSGFTSKKIDTLSITGSDLYLGPNNTYYFEPDATNLEKVRKTLQEHLDYTPDT STGTSGTEDGTDSSSSSGSTGSTGTTTDGTTNGSSYSNDSSTSSNNSTTNSTTDSSY* " /label="tagV CDS" gene 3131720..3132895 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /label="tagV gene" promotor_-10 complement(3132011..3132029) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3132020) /Source="Nicolas_upshifts" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3132043..3132049) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3132867 /Source="Nicolas_upshifts" /id="D1837" /incds=0 /nref=199 /ntot=276 /MaxReadThrough="2.38202" /MaxDrop="7.1642" /score="16.6000843" /energy="-18.6" /TU="NA" /idTUdmin="U2782" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(3132968..3134044) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /EC_number="2.7.8.33" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine:undecaprenyl-P N-acetylglucosaminyl-1-P transferase" /protein_id="NP_391433.1" /db_xref="EnsemblGenomes-Gn:BSU35530" /db_xref="EnsemblGenomes-Tr:CAB15570" /db_xref="GOA:O34753" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG12684" /db_xref="UniProtKB/Swiss-Prot:O34753" /translation="MLDERMIRIVVAFIVSLLTVLIITPIVKRIAIKIGAVDQPSNRK VHDKIMPRMGGLAIFIGVVAGVLASGIYTETRMTAITVGAFIIIVLGILDDKYQLSAK VKFLIQLGVAIMIVSTGLKMDFFSVPFLTERFELGWMAYPLTVLWIVGITNAINLIDG LDGLAAGLSVIGLSTIAVMALSGGKVLILSLSLVVIASTLGFLFYNFHPAKIFMGDTG SLFLGYSISILSLLGLYKSVTLFSIVIPIIILGVPIFDTTFAIIRRILNKQPISAPDK SHIHHRLMAFGLSHRMSVLVIYLIGFIFSISAIVLKSATIWLSLFIIFILIIFMQIIA EVTGLVNEKFKPFTKFYKRLVKRN*" /label="tagO CDS" gene complement(3132968..3134044) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /label="tagO gene" downshifts complement(3132984) /Source="Nicolas_upshifts" /id="D1838" /incds=0 /nref=221 /ntot=280 /MaxReadThrough="1.7614" /MaxDrop="8.41647" /score="29.109706" /energy="-11.6" /TU="NA" /idTUdmin="U2785" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 3133030..3133039 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3133053..3133072 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3133061..3134294 /Source="Nicolas_S_feature" /locus_tag="new_3648747_3649980" /HighExp="S8, S6, S7, S5, BT, S4, B36, Pyr, S3, G/S" /AntisenseName="tagO" /AntisenseCor="-0.60515751332040901" /AntisenseRegPval="-27.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1359" upshifts 3133061 /Source="Nicolas_upshifts" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3134045..3134127) /Source="Nicolas_S_feature" /locus_tag="new_3649731_3649813_c" /HighExp="LPhT, Cold, LoTm, T0.30H, T3.0H, LBGstat, T1.30H, T1.0H, T2.30H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67123699999999997" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1360" promotor_-10 complement(3134115..3134134) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3134127) /Source="Nicolas_upshifts" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3134146..3134152) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3134189..3135382) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391434.1" /db_xref="EnsemblGenomes-Gn:BSU35540" /db_xref="EnsemblGenomes-Tr:CAB15571" /db_xref="GOA:O32267" /db_xref="SubtiList:BG12695" /db_xref="UniProtKB/Swiss-Prot:O32267" /translation="METKEAIIHVIVATAEWGKDQLRYRRHRLAEFLAAQEETKEVIW VCPAPRAQGKEFQEVHSGIRQFAVKDLLQKKMFRFGRYTDVFYRHKLSPLLDELTPAS ANGERCCLWYTFPGFPLLSSLYSWDQVIYDCSDLWAAPISGRSNLLSEFRRKVIKSAE LRIIQRADSITCSSDYLHKEVDKKLTAGREKVHTVENGVEYELFSANKQAPDRSILQG REGIVLGFIGGIKPKLDFKMIKEAALQKPDWTFLWVGPDATNGDVSFQELLRLPNVIW TGPADPKEVPHYMELIDIGIMPYKQSPYNQAVFPLKLFEFLAAGKPVVGTNLPSTSKM QKPYVYEYVEGDHPIDFIAACEKVLGQNGDETYKEMRRNIARTQDWNCLFRQIMKYTG IQKHA*" /label="tuaH CDS" gene complement(3134189..3135382) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /label="tuaH gene" downshifts complement(3134219) /Source="Nicolas_upshifts" /id="D1839" /incds=0 /nref=23 /ntot=141 /MaxReadThrough="7.20583" /MaxDrop="4.88676" /score="4.72365619" /energy="-10.8" /TU="U2786" /idTUdmin="U2785" /TUdmin="-1236" /isTUend="FALSE" /label="downshifts" CDS complement(3135411..3136169) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391435.1" /db_xref="EnsemblGenomes-Gn:BSU35550" /db_xref="EnsemblGenomes-Tr:CAB15572" /db_xref="GOA:O32268" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12694" /db_xref="UniProtKB/Swiss-Prot:O32268" /translation="MTNWKPLVSVITPSYNARDYIEDTVHSVLDQSHPHWEMIIVDDC STDGTRDILQQYEKIDERIHVVYLEENSGAAVARNKALERAQGRYVAFLDSDDKWKKD KLEKQLEFMMERSCAFSFTGYSLMAQDGTPLDKFIHAPESLTYDDALKNTIIGCLTVM IDREQTGQIQMPNIRTRQDLATWLSLLKKGFTAYGMNECLAEYRLVNNSISSNKWKAA KKTWFVYREIERLHFMKATWCFVQYAKNAVKKRL*" /label="tuaG CDS" gene complement(3135411..3136169) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /label="tuaG gene" CDS complement(3136193..3136873) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase involved in teichuronic acid synthesis" /protein_id="NP_391436.1" /db_xref="EnsemblGenomes-Gn:BSU35560" /db_xref="EnsemblGenomes-Tr:CAB15573" /db_xref="GOA:O32269" /db_xref="InterPro:IPR003856" /db_xref="SubtiList:BG12693" /db_xref="UniProtKB/Swiss-Prot:O32269" /translation="MNDILIRIARRIKKNIIWIIAVPIILGAAGYILPSQIADQKSYT AEDTLAVGSYDHPVYNSTEEIPLLLKSDSFLKEALPDEKDEDVAEIKEKLTINTESKS LLTLSYSDEDKDRTESVLNAISSTFLKNDQKLYAEREAVIRSSIDALEGESVSEDSKV DKERFLYELKNTQLNLKAASVTDSETVSETAGGGMSPKKKAVLGVMIGLTIAFMFVVI PEFFRESF*" /label="tuaF CDS" gene complement(3136193..3136873) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /label="tuaF gene" CDS complement(3136902..3138368) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 15849754, 16850406, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative polymerase of teichuronic acid repeating units" /protein_id="NP_391437.1" /db_xref="EnsemblGenomes-Gn:BSU35570" /db_xref="EnsemblGenomes-Tr:CAB15574" /db_xref="GOA:O32270" /db_xref="InterPro:IPR007016" /db_xref="SubtiList:BG12692" /db_xref="UniProtKB/Swiss-Prot:O32270" /translation="MSIKRSAVHTLALLAAAIFGVVLLLGAIHKDIGFMQMAAVLAVL AIGLFLLTLATAFTTKERLFMAVIYILIACTFLNNAFFAIHLGFFSLFLYRLLLIAAG CLHIFGMVRNRTHIERWHGLQVKGILLFFAFWFIYGLVSLLWAKSVTVGLKYLALLAM GIFFIYLIVMYVQKMERLMIVYAIWLVMTVFLMIIGFYNHITHHHLASSTLYSGPEYK QHYPTSVFFNQNDFATFLSISFFFYITMMKNIKNGYIKAIGLVLSLCALYLIFATGSR ASLLGIFAGIAVYIFIVLPPVLKRMAIWLSAAGIALFAVLFASKIYSKFWELFLAPQT LHSFHDRLPSNVARANLLKNAWHFFLDSYGFGVGAGNVSYYLEHYAVYDTDNVAEVHN WLVEILANFGLFIMLGYLSVYAYLIWVLYKFYERKLENQSKLITEGLITAMVSFLVSS ISPSSVSNLFFHWVFMALVIAAVNVLRRSRQMPEPMYR*" /label="tuaE CDS" gene complement(3136902..3138368) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /label="tuaE gene" S_feature complement(3138369..3138452) /Source="Nicolas_S_feature" /locus_tag="new_3654055_3654138_c" /HighExp="LPhT, S3, B60, S7, S4, S6, LBGstat, BI, S8, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1361" CDS complement(3138453..3139838) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10376820, 10913081, 12970183, 16000785, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376820, 10913081, 12970183, 16000785, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 6-dehydrogenase (teichuronic acid)" /protein_id="NP_391438.1" /db_xref="EnsemblGenomes-Gn:BSU35580" /db_xref="EnsemblGenomes-Tr:CAB15575" /db_xref="GOA:O32271" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12691" /db_xref="UniProtKB/Swiss-Prot:O32271" /translation="MKKIAVIGTGYVGLVSGTCFAEIGNKVVCCDIDESKIRSLKNGV IPIYEPGLADLVEKNVLDQRLTFTNDIPSAIRASDIIYIAVGTPMSKTGEADLTYVKA AAKTIGEHLNGYKVIVNKSTVPVGTGKLVQSIVQKASKGRYSFDVVSNPEFLREGSAI HDTMNMERAVIGSTSHKAAAIIEELHQPFHAPVIKTNLESAEMIKYAANAFLATKISF INDIANICERVGADVSKVADGVGLDSRIGRKFLKAGIGFGGSCFPKDTTALLQIAKSA GYPFKLIEAVIETNEKQRVHIVDKLLTVMGSVKGRTISVLGLAFKPNTNDVRSAPALD IIPMLQQLGAHVKAYDPIAIPEASAILGEQVEYYTDVYAAMEDTDACLILTDWPEVKE MELVKVKTLLKQPVIIDGRNLFSLEEMQAAGYIYHSIGRPAVRGTEPSDKYFPGLPLE ELAKDLGSVNL*" /label="tuaD CDS" gene complement(3138453..3139838) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /label="tuaD gene" CDS complement(3139900..3141069) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391439.1" /db_xref="EnsemblGenomes-Gn:BSU35590" /db_xref="EnsemblGenomes-Tr:CAB15576" /db_xref="GOA:O32272" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG12690" /db_xref="UniProtKB/Swiss-Prot:O32272" /translation="MKILWITSVYPSSMKPGEGVFHETQVQELQKLGLDITVICPRPF HSAPVRMLKKTYRKKDVRPEYEIRKGIPVYRPFYRAVPGQLKWAQPHRRIASAVLKTM KQRDLYPDLIHAHFAMPSGGAAAVVSESAQIPYVLTLHGSDVNVYPHYSKGAFKAFKR AVGSASVVLAVSHKLQEEAKKLSGFDSSVLPIGIQLSRFQGNEETKEEIRKRLGLPLD QRLAVYVGRLVREKGIFELSEAIESLQDSPKAVFVGDGPAKSTLTQKGHIVTGQVPNH QVRDYLLAADLFVLPSYSEGMPTVVIEALALRVPVICTDVGGVSSLFGKHQHLLIKPK SAQALAEAITRYEHEQIWKPEVADDLYETVQAQFDAGKNAKALHHQYQTVTKTSV*" /label="tuaC CDS" gene complement(3139900..3141069) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /label="tuaC gene" CDS complement(3141066..3142517) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10048024, 11994144, 15849754, 16850406, 22720735, 26284661; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative exporter involved in biosynthesis of teichuronic acid" /protein_id="NP_391440.1" /db_xref="EnsemblGenomes-Gn:BSU35600" /db_xref="EnsemblGenomes-Tr:CAB15577" /db_xref="GOA:O32273" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG12689" /db_xref="UniProtKB/Swiss-Prot:O32273" /translation="MPSITKQIMSGAKWTSISTMCITIIQIVQFALLGNMMTLTEFGL VGMITTVTVFAQIVLDMGFGAALIQRDDATERQLSTLYWLNIMTGVLLFVLLYVSSPV IAGFYQREELVFLVRILAIMFLIAPIGQQYQYMLQKQLHFNTLSKIEIFSNVLSFGYL AIAVFMMDAILAYVISQVLLQSSKGILYWAVYRKKWHPAFVFDLRGMKDFFSFGAFQL SSRLVNRLGANIDMILIGRFIGAEALGIYNLAYQIVTIPVLKINPIVTRVAFPIFAKN KYENSVIREGFLNMTKMLALVSFPLLIGLVSVSDAFITAVFGEKWLAAVPILNVLAIV GILRVLMNPNGSVLLAKGRADLAFYWDSGVLLLYGLSLFAAVQTGSLLTVAWVYAIIS VVNFLIGRWLLAYVIKLNLSAYFQSIMKPFLITAAMGIIAFGVSLSTEHFSMQAEMRL AISVAAGALCYLFLLVKAYPQTKSKLLRKGRLS*" /label="tuaB CDS" gene complement(3141066..3142517) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /label="tuaB gene" CDS complement(3142573..3142722) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; C-terminal part of TuaA" /db_xref="SubtiList:BG12688" /translation="WAQVNGGYDMTPKEKLIFDLYYIRNLTFTLELKIMLKTCKVVWT GDGAR*" /label="tuaAc CDS" gene complement(3142573..3142722) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /pseudo /label="tuaAc gene" CDS complement(3142667..3143206) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /EC_number="2.7.8.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 10048024, 11994144, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; N-terminal part of TuaA" /translation="MSAEKSMNVSREFSVQQIHSFTLSEKTARYLAIKRVMDIWFALI GLAIALPMIAVFSILICLETPGPAIYTQERVGKGGKPFKLYKLRSMKIDAEKSGAVWA QKQDPRVTRIGAFIRRTRIDELPQLFNVLKGDMSMIGPRPERPVFTEKFQNEIPGFTQ RLGSGERRLRYDAEGKADI*" /label="tuaAn CDS" gene complement(3142667..3143206) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /pseudo /label="tuaAn gene" misc_feature complement(3143262..3143279) /Source="Nicolas_upshift_promotors" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3143266) /Source="Nicolas_upshifts" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3143433..3144923) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /EC_number="3.5.1.28" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1357079, 9537764, 14594841, 17298895, 19542270, 22469514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9537764, 14594841, 17298895, 19542270, 22469514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (major autolysin)" /protein_id="NP_391442.1" /db_xref="EnsemblGenomes-Gn:BSU35620" /db_xref="EnsemblGenomes-Tr:CAB15579" /db_xref="GOA:Q02114" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007253" /db_xref="SubtiList:BG10407" /db_xref="UniProtKB/Swiss-Prot:Q02114" /translation="MRSYIKVLTMCFLGLILFVPTALADNSVKRVGGSNRYGTAVQIS KQMYSTASTAVIVGGSSYADAISAAPLAYQKNAPLLYTNSDKLSYETKTRLKEMQTKN VIIVGGTPAVSSNTANQIKSLGISIKRIAGSNRYDTAARVAKAMGATSKAVILNGFLY ADAPAVIPYAAKNGYPILFTNKTSINSATTSVIKDKGISSTVVVGGTGSISNTVYNKL PSPTRISGSNRYELAANIVQKLNLSTSTVYVSNGFSYPDSIAGATLAAKKKQSLILTN GENLSTGARKIIGSKNMSNFMIIGNTPAVSTKVANQLKNPVVGETIFIDPGHGDQDSG AIGNGLLEKEVNLDIAKRVNTKLNASGALPVLSRSNDTFYSLQERVNKAASAQADLFL SIHANANDSSSPNGSETYYDTTYQAANSKRLAEQIQPKLAANLGTRDRGVKTAAFYVI KYSKMPSVLVETAFITNASDASKLKQAVYKDKAAQAIHDGTVSYYR*" /label="lytC CDS" gene complement(3143433..3144923) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /label="lytC gene" downshifts complement(3143455) /Source="Nicolas_upshifts" /id="D1840" /incds=0 /nref=145 /ntot=213 /MaxReadThrough="3.26689" /MaxDrop="6.50948" /score="13.9455176" /energy="-13.3" /TU="NA" /idTUdmin="U2788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3144962..3147079) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 16306698, 17269748" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 16306698, 17269748; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modifier of major autolysin amidase LytC" /protein_id="NP_391443.1" /db_xref="EnsemblGenomes-Gn:BSU35630" /db_xref="EnsemblGenomes-Tr:CAB15580" /db_xref="GOA:Q02113" /db_xref="InterPro:IPR007253" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="SubtiList:BG10406" /db_xref="UniProtKB/Swiss-Prot:Q02113" /translation="MKSCKQLIVCSLAAILLLIPSVSFAADSNISVKLLNYIGNKSSI SLSPTGFYKVTGDNVAVTDRFAGASRYETATLASNSQWKNPNTVILVNRDIFIDALPV IPLAKKLNAPVLFTQPDTLTKTTERQIAKFNPDNILIIGGARSISKDVENKLKSYGAV KRISGKNRYVLSENIAKQMGSYDKAIVVTGRVFQDALAIAPYAAAHGYPILLTEKDKL PDYDLPKQVIIIGSSFSVSDSVENQIKKTSTVQRIPGSTRYELTANIIKQLKLKADKV VMTNGTKYADVLIGASLASKKNSQILFVKQDSVPAAAKSITKDKATYAYDFIGSTSSI SAEVENSLADEFYLADGGTYNLKINSGKLNLENIKTYGNSLRIKPENYSTSNRISLDG KQYLGTVNFSIESTKYIRPVNENIPFEDYLKGVIPNEMPASWSLEALKAQTVAARTYS ITKTGTTVPDTTAFQVYGGYSWNSNTNKAVEQTKGKVLKYNGSLITAAYSSSNGGYTE ASNEVWSSSVPYLIAKKDTKDPQIGWTLTLSKQQLDTKSLDLTKPSSWWSSATETDSA RLSGVKNWILKNKETSADSVKIASIDDLSFSGTTQGQRAKTASMKVKYFVKSSTGSYN LSKITTISVPTSELRTMIGATVFKSTYVTVKKDTSKYTISGKGYGHGIGMSQYGAKAR AEAGDSYSSILKFYYPGTTLTSY*" /label="lytB CDS" gene complement(3144962..3147079) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /label="lytB gene" CDS complement(3147103..3147411) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1357079, 10974124, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 10974124, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="membrane bound lipoprotein" /protein_id="NP_391444.1" /db_xref="EnsemblGenomes-Gn:BSU35640" /db_xref="EnsemblGenomes-Tr:CAB15581" /db_xref="GOA:Q02112" /db_xref="SubtiList:BG10405" /db_xref="UniProtKB/Swiss-Prot:Q02112" /translation="MKKFIALLFFILLLSGCGVNSQKSQGEDVSPDSNIETKEGTYVG LADTHTIEVTVDNEPVSLDITEESTSDLDKFNSGDKVTITYEKNDEGQLLLKDIERAN *" /label="lytA CDS" gene complement(3147103..3147411) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /label="lytA gene" downshifts 3147317 /Source="Nicolas_upshifts" /id="D1841" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.03108" /MaxDrop="2.46089" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2787" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-35 3147407..3147411 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3147420..3147434 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3147421..3147439) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3147427 /Source="Nicolas_upshifts" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3147453..3147460) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3147456) /Source="Nicolas_upshifts" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3147477..3147485 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3147499..3147512 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3147517 /Source="Nicolas_upshifts" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="upshifts" CDS 3147595..3148515 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 9636707, 12034833, 19099556, 28197687, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9636707, 12034833, 19099556, 28197687, 29107701; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain of major autolysin expression" /protein_id="NP_391445.1" /db_xref="EnsemblGenomes-Gn:BSU35650" /db_xref="EnsemblGenomes-Tr:CAB15582" /db_xref="GOA:Q02115" /db_xref="InterPro:IPR004474" /db_xref="InterPro:IPR023734" /db_xref="SubtiList:BG10404" /db_xref="UniProtKB/Swiss-Prot:Q02115" /translation="MRNERRKKKKTLLLTILTIIGLLVLGTGGYAYYLWHKAASTVAS IHESIDKSKKRDKEVSINKKDPFSVLIMGVDERDGDKGRADTLIYMTVNPKTNTTDMV SIPRDTYTKIIGKGTMDKINHSYAFGGTQMTVDTVENFLDVPVDYFVKVNMESFRDVV DTLGGITVNSTFAFSYDGYSFGKGEITLNGKEALAYTRMRKEDPRGDFGRQDRQRQVI QGIINKGANISSITKFGDMFKVVENNVKTNLTFDNMWDIQSDYKGARKHIKQHELKGT GTKINGIYYYQADESALSDITKELKESLEK*" /label="tagU CDS" gene 3147595..3148515 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /label="tagU gene" downshifts 3148505 /Source="Nicolas_upshifts" /id="D1842" /incds=0 /nref=224 /ntot=261 /MaxReadThrough="0.434639999999999" /MaxDrop="6.11301" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2789" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3148555..3149697) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /EC_number="5.1.3.14" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12107153, 16952950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12107153, 16952950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmannosamine 2-epimerase" /protein_id="NP_391446.1" /db_xref="EnsemblGenomes-Gn:BSU35660" /db_xref="EnsemblGenomes-Tr:CAB15583" /db_xref="GOA:P39131" /db_xref="InterPro:IPR003331" /db_xref="InterPro:IPR029767" /db_xref="PDB:1O6C" /db_xref="PDB:4FKZ" /db_xref="SubtiList:BG10403" /db_xref="UniProtKB/Swiss-Prot:P39131" /translation="MKKLKVMTVFGTRPEAIKMAPLVLELKKYPEIDSYVTVTAQHRQ MLDQVLDAFHIKPDFDLNIMKERQTLAEITSNALVRLDELFKDIKPDIVLVHGDTTTT FAGSLAAFYHQIAVGHVEAGLRTGNKYSPFPEELNRQMTGAIADLHFAPTGQAKDNLL KENKKADSIFVTGNTAIDALNTTVRDGYSHPVLDQVGEDKMILLTAHRRENLGEPMEN MFKAIRRIVGEFEDVQVVYPVHLNPVVREAAHKHFGDSDRVHLIEPLEVIDFHNFAAK SHFILTDSGGVQEEAPSLGKPVLVLRDTTERPEGVEAGTLKLAGTDEENIYQLAKQLL TDPDEYKKMSQASNPYGDGEASRRIVEELLFHYGYRKEQPDSFTGK*" /label="mnaA CDS" gene complement(3148555..3149697) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /label="mnaA gene" downshifts complement(3148579) /Source="Nicolas_upshifts" /id="D1843" /incds=0 /nref=126 /ntot=236 /MaxReadThrough="0.41249" /MaxDrop="5.56107" /score="7.64930656" /energy="-11" /TU="NA" /idTUdmin="U2790" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3149736..3149755) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3149750) /Source="Nicolas_upshifts" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3149770..3149773) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3149826..3149830 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3149846..3149865 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3149847..3149942 /Source="Nicolas_S_feature" /locus_tag="new_3665533_3665628" /HighExp="C90, dia5, Salt, Lbexp, T1.0H, MG 5, GM 90, MG 45, LoTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1362" upshifts 3149848 /Source="Nicolas_upshifts" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="upshifts" CDS 3149943..3150821 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2846750, 8126437, 8320212, 9658024, 17662947, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846750, 8126437, 8320212, 9658024, 17662947, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_391447.1" /db_xref="EnsemblGenomes-Gn:BSU35670" /db_xref="EnsemblGenomes-Tr:CAB15584" /db_xref="GOA:Q05852" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10402" /db_xref="UniProtKB/Swiss-Prot:Q05852" /translation="MKKVRKAIIPAAGLGTRFLPATKAMPKEMLPIVDKPTIQYIIEE AVEAGIEDIIIVTGKSKRAIEDHFDYSPELERNLEEKGKTELLEKVKKASNLADIHYI RQKEPKGLGHAVWCARNFIGDEPFAVLLGDDIVQAETPGLRQLMDEYEKTLSSIIGVQ QVPEEETHRYGIIDPLTSEGRRYQVKNFVEKPPKGTAPSNLAILGRYVFTPEIFMYLE EQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYDVGEKLGFITTTLEFAMQDKELR DQLVPFMEGLLNKEEI*" /label="gtaB CDS" gene 3149943..3150821 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /label="gtaB gene" S_feature 3150822..3151913 /Source="Nicolas_S_feature" /locus_tag="new_3666508_3667599" /HighExp="Etha, Gly, C30, M9-stat, B60, T1.30H, B36, T1.0H, M40t90, T0.30H" /AntisenseName="yvzH" /AntisenseCor="-0.24043295548020899" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1363" S_feature complement(3150891..3151246) /Source="Nicolas_S_feature" /locus_tag="new_3666577_3666932_c" /HighExp="C30, LPh, HPh, Gly, G135, HiOs, aero, GM 25, MG 25, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.74940200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig="0.996" /label="S1364" CDS 3151155..3151373 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514004.1" /translation="MATILIPLTTLLDLSRIVGLIENHGIKPASIQTIKGTSPIPVMT SLLLRIPNTNQYAIIRIRGFKTCHNTPK*" /label="hypothetical protein CDS" gene 3151155..3151373 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /label="gene" CDS complement(3151247..3151330) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative teichoic acid translocation permease protein tagG (fragment)" /db_xref="PSEUDO:CAX52700.1" /translation="MMAYWFVFGMRNSKLVITGIGEVPFIV*" /label="yvzH CDS" gene complement(3151247..3151330) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /pseudo /label="yvzH gene" S_feature complement(3151331..3151522) /Source="Nicolas_S_feature" /locus_tag="new_3667017_3667208_c" /HighExp="HPh, LPh, C30, Gly, S0, HiOs, aero, G135, Mal, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1365" CDS complement(3151523..3154225) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16735734" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16735734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase" /protein_id="NP_391448.1" /db_xref="EnsemblGenomes-Gn:BSU35680" /db_xref="EnsemblGenomes-Tr:CAB15585" /db_xref="GOA:P46918" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR007554" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11192" /db_xref="UniProtKB/Swiss-Prot:P46918" /translation="MNEKSFNYDFSVIMPIYNVELYLTEAIESIINQTIGFENIQLIL VNDDSPDKSEIICKEYAQKYPNNIVYAKKQNGGVSSARNYGLKYAEGRYIQFLDPDDL VSEGTFENVLNFFDEHKNEIDIVAIPIFFAEGRTGEHNLNNKFSSTRILDVEKEPHHI LTHCCSTFIKKDALKNIRFDENCKIGEDAKLVNLIISQKKKYGLVKEAKYHYRVREDG SSAMQTAKANKNWFNHSLITFSKNLIDIIKNHEQKIPLFLQYMVMHDLKWKLLIKDIS ETPLDENEYSEFLTLIREVLSYIDDDVIIETKSVSHFYLYHALKIKHGENYSRYVYER ETEQDYYLYREGKIVSKLSDQTLTIEILEENEDSIHIEGFWSSLFNSKGFKFYAKIGE TKIKAKNIKRQHNDYISLGEVIKKYPGFSIDIPKGHLADNHHIEFFITKGKKRKLTKL RFFKYSGLSNDLYNTYVAKKDYIFYYNYKKLMFKKNNFKNRFIKEFRFLKSLHKSGEK SKKRKSAIKKALMARMVHHVFTIFNRKPVWLFIDRQDKADDNAEHLFKYAINKNDGVK KYFIIKKDSKDYDRIKKYGKVIPYRSFRHKILTLSSSKVISTHADIWVVNPFFNMEIY FRDLFNFEFIFLQHGITMADHSEWLNKYNKNIKLLVTSAKPEYRSIVKGNYNYKKENI LLGGFPRYDNLKKSEGEKQLLIMPTWRKDIVLPKDQAKGVRPYNPKFKDSEYFSRYNA LINDERLIEFAKKNNYKITFFPHPDIQQQIVDFEKHDYVEFADYNSSYQMLFNSSNIM ITDFSSVAFDFAYEKKPVIYYQYEKSYHFKLDYYDYKKMGFGDVLENHNSLVDKVIYY MKNNSRMEDKYRKRVDNFFAYTDKNNRNRIYNAILELDNNKVAK*" /label="ggaB CDS" gene complement(3151523..3154225) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /label="ggaB gene" S_feature complement(3154226..3154348) /Source="Nicolas_S_feature" /locus_tag="new_3669912_3670034_c" /HighExp="BMM, HiOs, MG 15, C30, SMM, GM 90, HPh, MG 150, MG 25, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1366" promotor_-35 3154247..3154253 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3154268..3154286 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3154273..3157105 /Source="Nicolas_S_feature" /locus_tag="new_3669959_3672791" /HighExp="Sw, LoTm, M9-stat, Salt, B60, T0.30H, Gly, T1.0H, B36, BI" /AntisenseName="ggaA" /AntisenseCor="-0.503651102561819" /AntisenseRegPval="-18" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1367" upshifts 3154273 /Source="Nicolas_upshifts" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3154349..3155689) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16735734, 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase (missing signal peptide)" /db_xref="EnsemblGenomes-Gn:BSU35690" /db_xref="EnsemblGenomes-Tr:CAB15586" /db_xref="GOA:P46917" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PSEUDO:CAB15586.1" /db_xref="SubtiList:BG11367" /db_xref="UniProtKB/Swiss-Prot:P46917" /translation="MFSIIIPIYNSENYLRYSIESVLNQSIGFKENIELILIDDGSVD SSPQICESFKNLYPNNIKIMKIENSGPSAARNCGLSNVSERSKFIGFLDSDDAFSQNA LQSVYDFFCDSEHVNIAVLPVYYTGEKEGGHKLNNRFEKGTRVINILNDYKAIHFYIG GTFYRRHTLTSTVLFDESIKFWEDAIFFNQLLLKEKRYGAVAEGKYFYRKRKEQDSLV DRSWFNKKRYTYLLNECYMTLLMDSFNKYDIVLPYLQFLIVYHIKLFLYPNYRDVYKS VLDQQEQRVFVDDFIKVLKFIDPQFIKEQDMPMYYKEFMFHLLKENTEALENIKKERV LHSSCTVTSAKIKGLRLELTGHFINQYYEMKENDRIYIKYFKRLKKCKRKELKKTIEV WGYKLRDFRYAGFVVEIPIWAFAFDFVLKTPNDSLELNHVNIFKSLLTRVFKKR*" /label="ggaA CDS" gene complement(3154349..3155689) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /pseudo /label="ggaA gene" CDS complement(3155730..3155936) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /EC_number="2.7.8.12" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase (fragment)" /db_xref="PSEUDO:CAX52701.1" /translation="MYDLPAYRDCIRGFYFNFQQKTPGNLLQTSEELIDTVKELLHNP YIDHNYEDFYNKFCNLEEARLLKE*" /label="yvzI CDS" gene complement(3155730..3155936) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /pseudo /label="yvzI gene" S_feature complement(3155937..3156810) /Source="Nicolas_S_feature" /locus_tag="new_3671623_3672496_c" /HighExp="HiOs, Heat, BMM, MG 15, GM 90, MG 25, MG 150, C30, GM 25, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99943499999999996" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1368" promotor_-10 complement(3156804..3156823) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3156810) /Source="Nicolas_upshifts" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3156812..3157051) /Source="Nicolas_S_feature" /locus_tag="new_3672498_3672737_c" /HighExp="Cold, LBGstat, C30, GM 25, GM 15, GM 45, GM 60, GM 10, GM-0.2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1369" promotor_-35 complement(3156836..3156842) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3157033..3157051) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-10" upshifts complement(3157051) /Source="Nicolas_upshifts" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="upshifts" promotor_-35 complement(3157065..3157072) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-35" promotor_-35 3157074..3157081 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3157093..3157112 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3157107..3157237 /Source="Nicolas_S_feature" /locus_tag="new_3672793_3672923" /HighExp="Sw, T0.30H, LoTm, B60, T1.0H, Lbtran, C30, LBGtran, dia5, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1370" upshifts 3157107 /Source="Nicolas_upshifts" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box 3157179..3157279 /Source="Nicolas_upshift_promotors" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3157239 /Source="Nicolas_upshifts" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="upshifts" CDS 3157243..3157839 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /EC_number="2.7.7.9" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase (UDP-glucose pyrophosphorylase) (UDPGP) (fragment)" /db_xref="PSEUDO:CAX52702.1" /translation="MISFFHYILQKEPKGLGHAVWFAPNFIGDEPFAFLLGDDIVQAD TPGLRQLTDEYERTLSSIIGVQQVPEDETHCYGIIAPLTSEGRRYQVKNFIEKPPKDT APSNLAILGRYVFTPEIFMYLEEQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYD VGEKLGFITTTLEFAMQDKELRDQLVPFMEGLLNKEEI*" /label="yvzE CDS" gene 3157243..3157839 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /pseudo /label="yvzE gene" downshifts 3157437 /Source="Nicolas_upshifts" /id="D1844" /incds=1 /nref=94 /ntot=183 /MaxReadThrough="4.62614" /MaxDrop="5.15039" /score="34.2325445" /energy="-14.3" /TU="U2792,U2795" /idTUdmin="U2796" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3157878..3159461) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /EC_number="3.6.3.40" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 17012386, 18156271; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding teichoic acid precursor transporter component" /protein_id="NP_391451.1" /db_xref="EnsemblGenomes-Gn:BSU35700" /db_xref="EnsemblGenomes-Tr:CAB15587" /db_xref="GOA:P42954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015860" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030284" /db_xref="SubtiList:BG11191" /db_xref="UniProtKB/Swiss-Prot:P42954" /translation="MKLKVSFRNVSKQYHLYKKQSDKIKGLFFPAKDNGFFAVRNVSF DVYEGETIGFVGINGSGKSTMSNLLAKIIPPTSGEIEMNGQPSLIAIAAGLNNQLTGR DNVRLKCLMMGLTNKEIDDMYDSIVEFAEIGDFINQPVKNYSSGMKSRLGFAISVHID PDILIIDEALSVGDQTFYQKCVDRINEFKKQGKTIFFVSHSIGQIEKMCDRVAWMHYG ELRMFDETKTVVKEYKAFIDWFNKLSKKEKETYKKEQTEERKKEDPEAFARFRKKKKK PKSLANAIQIAILSILTVFMAGTMFFNAPLRTIASFGAIPQNEVKNHHGDAKGKSEER LTAINKQGFIANEKAAAYKDQGLKQKADVTLPFGTKVTVAAKGKQAAKIKFDGHSYYV KQSAVATNMKHAELHATAFTSYVSQNAASSYEYFLKFLGDSSTSIQSKLNGYTEGNKA DGRKTLNFDYEKISYVLENDKATELIFHNISPINPASLSLSDSDVLYDSSKKRFLVNT DDQVFAVDNEEHTLTLMLK*" /label="tagH CDS" gene complement(3157878..3159461) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /label="tagH gene" downshifts 3157921 /Source="Nicolas_upshifts" /id="D1845" /incds=0 /nref=2 /ntot=19 /MaxReadThrough="1.20059" /MaxDrop="5.25978" /score="34.2325445" /energy="-14.3" /TU="NA" /idTUdmin="U2792" /TUdmin=440 /isTUend="FALSE" /label="downshifts" CDS complement(3159481..3160308) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 15849754, 16850406, 17012386, 18156271, 27213893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="teichoic acid precursors permease" /protein_id="NP_391452.1" /db_xref="EnsemblGenomes-Gn:BSU35710" /db_xref="EnsemblGenomes-Tr:CAB15588" /db_xref="GOA:P42953" /db_xref="InterPro:IPR000412" /db_xref="InterPro:IPR013525" /db_xref="SubtiList:BG11205" /db_xref="UniProtKB/Swiss-Prot:P42953" /translation="MNDLLRILREQITSFPLILRLAAYETKSKYQMNYLGVLWQFLNP LIQMLAYWFVFGMGIRKGGPVTTGAGEVPFIIWMLAGLIPWFFISPTILDGSNSVFKR INMVAKMNFPISSLPSVAIASNLFSYMIMMVIYIIVLLVNGVFPSVHWLQYIYYFICM IAFMFSFSLFNSTISVLIRDYQFLLQAVTRLLFFLLPIFWDVNAKLGQSHPELVPVLK LNPLFYIIEGFRNSFLDGAWFFHDMKYTLYFWLFTFLLLLVGSILHMKFRDKFVDFL* " /label="tagG CDS" gene complement(3159481..3160308) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /label="tagG gene" S_feature complement(3160309..3160373) /Source="Nicolas_S_feature" /locus_tag="new_3675995_3676059_c" /HighExp="H2O2, LBGstat, dia15, Oxctl, LBGexp, G150, Paraq, G180, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1371" promotor_-10 complement(3160369..3160388) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3160373) /Source="Nicolas_upshifts" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3160375..3160472) /Source="Nicolas_S_feature" /locus_tag="new_3676061_3676158_c" /HighExp="G180, G135, Cold, G150, LPh, S0, Oxctl, Paraq, HPh, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1372" promotor_-35 complement(3160404..3160407) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3160473..3162713) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /EC_number="2.7.8.12" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase (poly(glycerol phosphate) polymerase)" /protein_id="NP_391453.1" /db_xref="EnsemblGenomes-Gn:BSU35720" /db_xref="EnsemblGenomes-Tr:CAB15589" /db_xref="GOA:P13485" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10725" /db_xref="UniProtKB/Swiss-Prot:P13485" /translation="MSLVVDTNKRKQKGKSFYTEEQKKVMIENTVIKCILKSLKNNLG SLELLISIDSEHQFLEDYQLFLKLKERRSGTESEFPLQNTGSLEYKTEINAHVLPMPV EMGQTYDFYVEFRKKYEDAEQEPLLKRLSAEVNSIERAFHVDQTTELLILPYTTDKGN FSIKVKREAKIIRFDQIEISSEEISITGYAGYLSSENQYRIKNLNLILKKGGETPIEE KFPIKLERKTHGLENMRADGFVPELYDFEVKVPLKEIPFSNEKRYVYRLFMEYICNDD EGTDIQFNSTALVLGDRKNKLKGLVSIIKTNNAPVRYEVFKKKKKQTLGIRVNDYSLK TRMKYFIKGKKKRLVSKIKKITKMRNKLITKTYKSLFMMASRMPVKRKTVIFESFNGK QYSCNPRAIYEYMRENHPEYKMYWSVNKQYSAPFDEKGIPYINRLSLKWLFAMARAEY WVVNSRLPLWIPKPSHTTYLQTWHGTPLKRLAMDMEEVHMPGTNTKKYKRNFIKEASN WDYLISPNGYSTEIFTRAFQFNKTMIESGYPRNDFLHNDNNEETISLIKSRLNIPRDK KVILYAPTWRDDQFYAKGRYKFDLDLDLHQLRQELGNEYIVILRMHYLVAENFDLGPF EGFAYDFSAYEDIRELYMVSDLLITDYSSVFFDFANLKRPMLFFVPDIETYRDKLRGF YFDFEKEAPGPLVKTTEETIEAIKQISSPDYKLPVSFGPFYDKFCYLESGRSSEKVVN TVFKAE*" /label="tagF CDS" gene complement(3160473..3162713) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /label="tagF gene" CDS complement(3162713..3164734) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /EC_number="2.4.1.52" /function="16.8: Protect" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose:polyglycerol phosphate alpha-glucosyltransferase" /protein_id="NP_391454.1" /db_xref="EnsemblGenomes-Gn:BSU35730" /db_xref="EnsemblGenomes-Tr:CAB15590" /db_xref="GOA:P13484" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR015397" /db_xref="SubtiList:BG10724" /db_xref="UniProtKB/Swiss-Prot:P13484" /translation="MSLHAVSESNIKQIPDMDYYFISGGLPSNYGGLTKSLLLRSKLF GEECNQNTFFLTFRFDLELSSKIDELYSNGKIDKKFTSVINLFDDFLSVRTNGKRSYE ERIGLDQIKKQVGMGKFAKTLLRLFGKKNNEMSVVYYGDGETIRYVDYWNDKNQLIKR EEYTKNGNLVLVTHYDVQLNKMYLQEYINDQNQVYLDKLYVWNNEEKDVQLSHIIWYS LEGEIKVKDESELRQYWIEYLQKQNDKPKLFLVDSRPQDKHVFKVKKSPSSYYGAIIH NKHYGSNKYQIKGRYKEVFSQMYNLDAVFFITEEQLEDFKLISGEQETFFFTPHTIDK PLDPAVLNVPSEKYKAVIISRLASMKNLIHAVKAFSLVVKEIPEAKLDIFGSGEDFEK IKKEIEDTKLQNNVFLKGYTDNPDSEFQKAWLTISTSHFEGFGLSNMEALSNGCPVVT YDYDYGARSLVTDGANGYVIEQYNIEKLGQAIISLMKDESTHQKFSEQAFKMAEKYSR PNYIENWAFALNQMIEVRIEREKFSKKVGKKDPSISSYTEDFDKTKIEIDIENFDHND IKKIRLVGLDRKNKAEIISTNLQNDQLFVIDLEKDVNIEKIAANKTQVIDFYIVFNAN GHIKTMRRLSSEETKLSGNSIDTNNGYRVEPYTTVKGNFSWRVTEIKES*" /label="tagE CDS" gene complement(3162713..3164734) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /label="tagE gene" promotor_-35 3163476..3163485 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3163498..3163513 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3163509 /Source="Nicolas_upshifts" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3164735..3164894) /Source="Nicolas_S_feature" /locus_tag="new_3680421_3680580_c" /HighExp="G180, G135, Cold, G150, Oxctl, LBGexp, Paraq, Lbexp, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1373" CDS complement(3164895..3165284) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /EC_number="2.7.7.39" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol-3-phosphate cytidylyltransferase" /protein_id="NP_391455.1" /db_xref="EnsemblGenomes-Gn:BSU35740" /db_xref="EnsemblGenomes-Tr:CAB15591" /db_xref="GOA:P27623" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR006409" /db_xref="InterPro:IPR014729" /db_xref="PDB:1COZ" /db_xref="PDB:1N1D" /db_xref="SubtiList:BG10449" /db_xref="UniProtKB/Swiss-Prot:P27623" /translation="MKKVITYGTFDLLHWGHIKLLERAKQLGDYLVVAISTDEFNLQK QKKAYHSYEHRKLILETIRYVDEVIPEKNWEQKKQDIIDHNIDVFVMGDDWEGKFDFL KDQCEVVYLPRTEGISTTKIKEEIAGL*" /label="tagD CDS" gene complement(3164895..3165284) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /label="tagD gene" S_feature complement(3165285..3165419) /Source="Nicolas_S_feature" /locus_tag="new_3680971_3681105_c" /HighExp="BC, Cold, T3.0H, HiOs, MG-0.2, T1.30H, T3.30H, LPhT, MG 15, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1374" promotor_-10 complement(3165403..3165422) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3165419) /Source="Nicolas_upshifts" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3165433..3165440) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3165574..3165580 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3165591..3165683 /Source="Nicolas_S_feature" /locus_tag="new_3681277_3681369" /HighExp="B60, LoTm, Cold, T3.30H, T3.0H, Salt, T5.0H, T4.0H, Lbexp, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1375" upshifts 3165591 /Source="Nicolas_upshifts" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3165592..3165611 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3165684..3166454 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /EC_number="2.4.1.187" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmannosamine (ManNAc) C4 hydroxyl of a membrane-anchored N-acetylglucosaminyl diphospholipid (GlcNAc-pp-undecaprenyl, lipid I) glycosyltransferase" /protein_id="NP_391456.1" /db_xref="EnsemblGenomes-Gn:BSU35750" /db_xref="EnsemblGenomes-Tr:CAB15592" /db_xref="GOA:P27620" /db_xref="InterPro:IPR004629" /db_xref="InterPro:IPR034714" /db_xref="SubtiList:BG10450" /db_xref="UniProtKB/Swiss-Prot:P27620" /translation="MQTETIHNIPYVNSNLTSFIDYLEKHYIDQKIGAVISTVNPEIA FAAIKDRDYFDVLSSSNFILPDGIGVVMMSRLTNNRLQSRIAGYDVFKELLGVANKKK KRIFLYGAKKDVIKGVVSKISSEYPNIKIAGYSDGYVQDRTLVAKQIARANPDMVFVA LGYPHQEKFIHNYRHLFPKAVSIGLGGSFDVFSGNVKRAPSWMIRLNLEWFYRLILNP WRWKRMLSIPKYALTVLKEEKNKKTFYPKPEKDHTKQI*" /label="tagA CDS" gene 3165684..3166454 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /label="tagA gene" S_feature complement(3165811..3166159) /Source="Nicolas_S_feature" /locus_tag="new_3681497_3681845_c" /HighExp="S8, S6, S7, S5, S4, G135, S3, C30, G180, ferm" /AntisenseName="tagA" /AntisenseCor="-0.35014495927301897" /AntisenseRegPval="-8.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1376" promotor_-10 complement(3166163..3166174) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3166167) /Source="Nicolas_upshifts" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3166189..3166195) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3166479 /Source="Nicolas_upshifts" /id="D1846" /incds=0 /nref=2 /ntot=103 /MaxReadThrough="6.64821" /MaxDrop="3.225" /score="-6.01444425" /energy="-10.9" /TU="U2800" /idTUdmin="U2800" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" CDS 3166487..3167632 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /EC_number="2.7.8.44" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid primase, CDP-glycerol:N-acetyl-beta-d-mannosaminyl-1, 4-N-acetyl-d-glucosaminyldiphosphoundecaprenyl glycerophosphotransferase" /protein_id="NP_391457.1" /db_xref="EnsemblGenomes-Gn:BSU35760" /db_xref="EnsemblGenomes-Tr:CAB15593" /db_xref="GOA:P27621" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10451" /db_xref="UniProtKB/Swiss-Prot:P27621" /translation="MKIRSLLANCYLYFLSAIAFFLQWVKPESKVTLLISFEANAKAI LEEYEQGQYSYKLNILYTQQASAIAESFPNVDAYLLQEKNPIHLIKAVYLMFNSKVII TDNYFLLTSVLNKRKQTKCIQVWHANGSLKKFGLEDITNMQRTKTDIKRFQKVYSSYD YLTVGSEEMANIFKKSFGIKDNQLLKIGVPLTDPYYRENKKKISDTLNIQRKKIILYA PTFRDYNMQSIQLPFTEEQLIHQLKEEYVLFVKLHPAIQNNIDIKYSSDYIKDVSNYA LFDLLMAADILITDYSSVPFEFSILNKPILFYTYDLKLYQQKRGLVDNYLSIIPGRAC YDSESLINEIQTPFNYSKIKVFSDRWNKYSDGNSSQNLLNFIENLIS*" /label="tagB CDS" gene 3166487..3167632 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /label="tagB gene" downshifts 3167620 /Source="Nicolas_upshifts" /id="D1847" /incds=0 /nref=101 /ntot=235 /MaxReadThrough="3.54908" /MaxDrop="5.95551" /score="-3.22062454" /energy="-10" /TU="U2800" /idTUdmin="U2800" /TUdmin="-1169" /isTUend="FALSE" /label="downshifts" promotor_-35 3167674..3167681 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3167696..3167715 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3167706 /Source="Nicolas_upshifts" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="upshifts" CDS 3167752..3169080 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7952180, 16269821; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polyglycerol phosphate assembly and export protein (teichoic acid biosynthesis)" /protein_id="NP_391458.1" /db_xref="EnsemblGenomes-Gn:BSU35770" /db_xref="EnsemblGenomes-Tr:CAB15594" /db_xref="GOA:P27622" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG10453" /db_xref="UniProtKB/Swiss-Prot:P27622" /translation="MRKKELFDFTNITPKLFTELRVADKTVLQSFNFDEKNHQIYTTQ VASGLGKDNTQSYRITRLSLEGLQLDSMLLKHGGHGTNIGIENRNGTIYIWSLYDKPN ETDKSELVCFPYKAGATLDENSKELQRFSNMPFDHRVTPALDMKNRQLAIRQYDTKNN NNKQWVTIFNLDDAIANKNNPLYTINIPDELHYLQGFFLDDGYLYWYTGDTNSKSYPN LITVFDSDNKIVLQKEITVGKDLSTRYENNFREPEGICMYTNPETGAKSLMVGITSGK EGNRISRIYAYHSYENFMNHVPMLRSPLLKTVGHQDTPPERFQPFIQTFILEYNAQNK KWMVPTSGYLPSYTSNLVRNITINADGNLQVTLNERYISLLHQSIEGDFRLKQKDIRM GSWYFAGGEKSNVLEIGFMKGSTKIRPDDAAISNASRMSIFMIVADKIEV*" /label="tagC CDS" gene 3167752..3169080 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /label="tagC gene" downshifts 3169075 /Source="Nicolas_upshifts" /id="D1848" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.77356" /MaxDrop="4.002" /score="-7.52215775" /energy="-19.3" /TU="NA" /idTUdmin="U2802" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3169136) /Source="Nicolas_upshifts" /id="D1849" /incds=0 /nref=141 /ntot=248 /MaxReadThrough="0.94732" /MaxDrop="5.40128" /score="-0.11635468" /energy="-19.3" /TU="NA" /idTUdmin="U2803" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3169140..3171782) /gene="lytD" /locus_tag="BSU_35780" /old_locus_tag="BSU35780" /EC_number="3.2.1.96" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9537764, 10206711, 17298895, 19542270, 22469514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9537764, 10206711, 17298895, 19542270, 22469514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported N-acetylglucosaminidase (major autolysin) (CWBP90)" /protein_id="NP_391459.1" /db_xref="EnsemblGenomes-Gn:BSU35780" /db_xref="EnsemblGenomes-Tr:CAB15595" /db_xref="GOA:P39848" /db_xref="InterPro:IPR002901" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="SubtiList:BG10455" /db_xref="UniProtKB/Swiss-Prot:P39848" /translation="MKKRLIAPMLLSAASLAFFAMSGSAQAAAYTDYSLYKVEPSNTF STESQASQAVAKLEKDTGWDASYQASGTTTTYQISASGIHSESEAKAILSGLAKQTSI TGTSSPVGSKQPYVTISSGAISGEKQANTILAKLKQETGVAGAVKAYGAAQPYMNVMT SDIADETKVKALIQSLAKQTGIKSSYQPITHTVSVTTIQSGTIVGDSRAAQIKNAFQK ESGLQASLKETVKGQAYYTFTTAAISGEANAKTLLQQLKQSTGITGSYKSINQKTTVE SYNVQSAYFKGLSTVKDAISQIKKNTGVSGSYQQVGKSTSYTVNMKGITKQQLQKIDT FFKKKKWHYTSSSVKKTTTSAAYQITTAKILGEQQANKAAAFFAQKKVKAAKTAAGST AENQYQLISEETSDQAKVTKGLNILKKNQLSASAKSVKKQIADTFKITTESLLDQTKV NQALTFFKSNHISVASQKTGQTAASSYQITTEAIISQEEIDRVLTFFKQNHIAVTTSK TGQTAYTQYKIVTTQLSSKTALNNGLTYLKSKSVTPSYTTKSNTLYKISVNEQFTGND TAAAASTKLKQLYGWTSSIVKIKNGPQIMKTNYNLSLRDMVQKQMTVSPQTDGAAYVS LTYINTATSTVTADVLNIRSTPEVSPTNVIGQFKKGDKVKVIGQINGWAKINLGWRNA SSDEVVQYVDPNNFSRDSKYYFQFLKLSQTAGLSVTEVNQKVLAGKGILTGRAKAFID AANQYSINELYLISHALLETGNGTSALANGLTYNGKTVYNMYGIGAYDSNPNYYGAKY AYEQGWFTPEAAIIGGAKFIGSSYIHNTAYNQDTLYKMRWSATATHQYATDIGWAYKQ VNRMYSLYSLLDGYTLYFDVPEYR*" /label="lytD CDS" gene complement(3169140..3171782) /gene="lytD" /locus_tag="BSU_35780" /old_locus_tag="BSU35780" /label="lytD gene" promotor_-10 complement(3170385..3170404) /Source="Nicolas_upshift_promotors" /id="U2803" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1231 /SigmaFactorBS="gatcaaacgaaagtcaatcagGCACTCACGTttttcaaatcg aATCATATATCAGTAGCAAGCcagaaaaccggtcagacagctgcgagcagctatcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3170387) /Source="Nicolas_upshifts" /id="U2803" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1231 /SigmaFactorBS="gatcaaacgaaagtcaatcagGCACTCACGTttttcaaatcg aATCATATATCAGTAGCAAGCcagaaaaccggtcagacagctgcgagcagctatcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3170417..3170426) /Source="Nicolas_upshift_promotors" /id="U2803" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1231 /SigmaFactorBS="gatcaaacgaaagtcaatcagGCACTCACGTttttcaaatcg aATCATATATCAGTAGCAAGCcagaaaaccggtcagacagctgcgagcagctatcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3171817..3171835) /Source="Nicolas_upshift_promotors" /id="U2804" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2808 /SigmaFactorBS="tttattagaaaatggaagtgattcacCTATAAATgaagcatg cgcgtGCCGATAAATAAACTAGTTttatatactcatagaataagaaagaggagaagga a" /listShort="lytD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3171822) /Source="Nicolas_upshifts" /id="U2804" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2808 /SigmaFactorBS="tttattagaaaatggaagtgattcacCTATAAATgaagcatg cgcgtGCCGATAAATAAACTAGTTttatatactcatagaataagaaagaggagaagga a" /listShort="lytD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3171849..3171856) /Source="Nicolas_upshift_promotors" /id="U2804" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2808 /SigmaFactorBS="tttattagaaaatggaagtgattcacCTATAAATgaagcatg cgcgtGCCGATAAATAAACTAGTTttatatactcatagaataagaaagaggagaagga a" /listShort="lytD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3171911..3172861) /gene="pmiA" /locus_tag="BSU_35790" /old_locus_tag="BSU35790" /EC_number="5.3.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7581999, 10704478, 19447949, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7581999, 10704478, 19447949, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannose-6-phosphate isomerase (active on aldose substrates with hydroxyl groups oriented in the same direction at the C-2 and C-3 positions as in mannose)" /protein_id="NP_391460.1" /db_xref="EnsemblGenomes-Gn:BSU35790" /db_xref="EnsemblGenomes-Tr:CAB15596" /db_xref="GOA:P39841" /db_xref="InterPro:IPR001250" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014628" /db_xref="InterPro:IPR014710" /db_xref="PDB:1QWR" /db_xref="SubtiList:BG10454" /db_xref="UniProtKB/Swiss-Prot:P39841" /translation="MTQSPIFLTPVFKEKIWGGTALRDRFGYSIPSESTGECWAISAH PKGPSTVANGPYKGKTLIELWEEHREVFGGVEGDRFPLLTKLLDVKEDTSIKVHPDDY YAGENEEGELGKTECWYIIDCKENAEIIYGHTARSKTELVTMINSGDWEGLLRRIKIK PGDFYYVPSGTLHALCKGALVLETQQNSDATYRVYDYDRLDSNGSPRELHFAKAVNAA TVPHVDGYIDESTESRKGITIKTFVQGEYFSVYKWDINGEAEMAQDESFLICSVIEGS GLLKYEDKTCPLKKGDHFILPAQMPDFTIKGTCTLIVSHI*" /label="pmiA CDS" gene complement(3171911..3172861) /gene="pmiA" /locus_tag="BSU_35790" /old_locus_tag="BSU35790" /label="pmiA gene" downshifts complement(3171923) /Source="Nicolas_upshifts" /id="D1850" /incds=0 /nref=29 /ntot=177 /MaxReadThrough="4.74566" /MaxDrop="3.72936" /score="9.64549533" /energy="-7.7" /TU="U2805" /idTUdmin="U2806" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3172886..3172904) /Source="Nicolas_upshift_promotors" /id="U2805" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=167 /SigmaFactorBS="cataggaaaaaggcagcttatacgggCGTTTGTaagaggggc gcaccGGGAAAATGATGATCAGTTatttacaggggaggggtacggatcatgacgcaat c" /listShort="yvyI, lytD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3172891) /Source="Nicolas_upshifts" /id="U2805" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=167 /SigmaFactorBS="cataggaaaaaggcagcttatacgggCGTTTGTaagaggggc gcaccGGGAAAATGATGATCAGTTatttacaggggaggggtacggatcatgacgcaat c" /listShort="yvyI, lytD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3172893..3173029) /Source="Nicolas_S_feature" /locus_tag="new_3688579_3688715_c" /HighExp="Lbtran, S0, M40t90, T1.0H, dia0, Mt0, Lbstat, M0t90, Lbexp, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.17043900000000001" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1377" promotor_-35 complement(3172919..3172925) /Source="Nicolas_upshift_promotors" /id="U2805" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=167 /SigmaFactorBS="cataggaaaaaggcagcttatacgggCGTTTGTaagaggggc gcaccGGGAAAATGATGATCAGTTatttacaggggaggggtacggatcatgacgcaat c" /listShort="yvyI, lytD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3173003..3173022) /Source="Nicolas_upshift_promotors" /id="U2806" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.664335664335664" /psig="0.994005994005994" /xcortree=1553 /SigmaFactorBS="tattaatttgtatcaaaaaaggagaattattcttatcgagga aaaggctgaaacaaagcttcttttcgaCGTGATATAATAGATAGGAAgcgttttcttt g" /listShort="S1377, yvyI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3173031) /Source="Nicolas_upshifts" /id="U2806" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.664335664335664" /psig="0.994005994005994" /xcortree=1553 /SigmaFactorBS="tattaatttgtatcaaaaaaggagaattattcttatcgagga aaaggctgaaacaaagcttcttttcgaCGTGATATAATAGATAGGAAgcgttttcttt g" /listShort="S1377, yvyI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3173059..3173065 /Source="Nicolas_upshift_promotors" /id="U2807" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=900 /SigmaFactorBS="cacgtcgaaaagaagctttgtttcagccttttcctcgataAG AATAAttctccttttttgATACAAATTAATaaaaaccgtcaatatgtttaagaaggag a" /listShort="gerBA, gerBB, gerBC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3173079..3173090 /Source="Nicolas_upshift_promotors" /id="U2807" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=900 /SigmaFactorBS="cacgtcgaaaagaagctttgtttcagccttttcctcgataAG AATAAttctccttttttgATACAAATTAATaaaaaccgtcaatatgtttaagaaggag a" /listShort="gerBA, gerBB, gerBC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3173079 /Source="Nicolas_upshifts" /id="U2807" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=900 /SigmaFactorBS="cacgtcgaaaagaagctttgtttcagccttttcctcgataAG AATAAttctccttttttgATACAAATTAATaaaaaccgtcaatatgtttaagaaggag a" /listShort="gerBA, gerBB, gerBC" /GFF_Attribute="listLong" /label="upshifts" CDS 3173126..3174577 /gene="gerBA" /locus_tag="BSU_35800" /old_locus_tag="BSU35800" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:3110007, 8012571, 10411756, 15774895, 22493018, 23749970, 25681191, 25790435" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110007, 8012571, 10411756, 15774895, 22493018, 23749970, 25681191, 25790435; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="component of germinant receptor B" /protein_id="NP_391461.2" /db_xref="EnsemblGenomes-Gn:BSU35800" /db_xref="EnsemblGenomes-Tr:CAB15597" /db_xref="GOA:P39569" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10640" /db_xref="UniProtKB/Swiss-Prot:P39569" /translation="MQIDSDLQNNLDTLKKTLGQNDDMMFYTFAFGDSRQKACLLYID GLTENKMLAQYVISPLQKEALAHKECSIEDLSAFFFGFHHSVVSTMKEIEQLVFSGQA ILLADGYRGGLAFDTKSVATRSLDEPSSEVVERGPKIGFIEKLRTNTALLRERTSDPN LVIKEMTLGKRTKKKIAVAYIQDIAPDYVVKEVFKRLKSVNIDNLPESGTLEQLIEDE PFSIFPTILSTERPDRVESSLLEGRVSILVDGTPFALIVPATVDEFIHSPDDYSQRWI PMSLVRLLRYSSILITIYLPGLYISLVSFHTGLLPTRMAISIAGSRLNVPFPPFVEAF IMIFTIELIREAGLRLPKPIGQTIGLIGGVVIGQAAVQAQIVSALMVIVVSVTALASF TVPSYAYNFPLRIIRIGVMISATALGMYGVIMVYLFVIGHLMRLKSFGQDYIIPIMAQ PGQDLKDTVIRIPTMFLKRRPTRNDPEDNIRQR*" /label="gerBA CDS" gene 3173126..3174577 /gene="gerBA" /locus_tag="BSU_35800" /old_locus_tag="BSU35800" /label="gerBA gene" CDS 3174583..3175689 /gene="gerBB" /locus_tag="BSU_35810" /old_locus_tag="BSU35810" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16352818, 16850406, 22493018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16352818, 16850406, 22493018; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="component of germinant receptor B" /protein_id="NP_391462.2" /db_xref="EnsemblGenomes-Gn:BSU35810" /db_xref="EnsemblGenomes-Tr:CAB15598" /db_xref="GOA:P39570" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG10641" /db_xref="UniProtKB/Swiss-Prot:P39570" /translation="MRKSEHKLTFMQTLIMISSTLIGAGVLTLPRSAAETGSPSGWLM ILLQGVIFIIIVLLFLPFLQKNSGKTLFKLNSIVAGKFIGFLLNLYICLYFIGIVCFQ ARILGEVVGFFLLKNTPMAVVVFIFLAVAIYHVGGGVYSIAKVYAYIFPITLIIFMML LMFSFRLFQLDFIRPVFEGGYQSFFSLFPKTLLYFSGFEIIFYLVPFMRDPKQVKKAV ALGIATSTLFYSITLLIVIGCMTVAEAKTVTWPTISLIHALEVPGIFIERFDLFLQLT WTAQQFACMLGSFKGAHIGLTEIFHLKNKNNAWLLTAMLAATFFITMYPKDLNDVFYY GTLLGYAFLIVITIPFFVWFLSWIQKKIGRGQLQ*" /label="gerBB CDS" gene 3174583..3175689 /gene="gerBB" /locus_tag="BSU_35810" /old_locus_tag="BSU35810" /label="gerBB gene" CDS 3175686..3176810 /gene="gerBC" /locus_tag="BSU_35820" /old_locus_tag="BSU35820" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16352818, 16850406, 20654628, 21685283, 22493018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16352818, 16850406, 20654628, 21685283, 22493018; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein component of the germination receptor B" /protein_id="NP_391463.1" /db_xref="EnsemblGenomes-Gn:BSU35820" /db_xref="EnsemblGenomes-Tr:CAB15599" /db_xref="GOA:P39571" /db_xref="InterPro:IPR008844" /db_xref="PDB:3N54" /db_xref="SubtiList:BG10642" /db_xref="UniProtKB/Swiss-Prot:P39571" /translation="MKTASKFSVMFFMLLALCGCWDVKDIEQLSFARGLAIDETNDHQ YKLTYQNLLPQSEDSQASGKPEFVNVTSHGKTILEAVSDVSIKDPPVYSDHLKVILLG EKLMRNQNVDQVLNHFIRDDELRRSSYLMAARGNAADVFTKGNPNQQQPMPSEKLIDL TTHSGYNGKIMIPLRIGRASVYSQNGYSYLIQAVKNEKGKAKYDGAGIIKRGSNKLVG FLSADETQTLSWVMGTIQGGVMPTTDKGHPITFEIKKSKTKIKPVIENGKPVFHISVK TKGILTEDQNPNENSFSKSYLHRLENIFEKKLERDVKQVMDKLQHEYKTDPVFLSDHI RIQHPDYWNKVKGHWDEIFSETDFKYDISFKIINFGTVGK*" /label="gerBC CDS" gene 3175686..3176810 /gene="gerBC" /locus_tag="BSU_35820" /old_locus_tag="BSU35820" /label="gerBC gene" S_feature complement(3175913..3176807) /Source="Nicolas_S_feature" /locus_tag="new_3691599_3692493_c" /HighExp="Etha, Sw, Salt, Heat, S8, B36, Gly, S7, LPhT, S6" /AntisenseName="gerBC" /AntisenseCor="0.12062795031199899" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1378" downshifts 3176800 /Source="Nicolas_upshifts" /id="D1851" /incds=0 /nref=18 /ntot=72 /MaxReadThrough="0.37711" /MaxDrop="4.85405" /score="35.6875936" /energy="-14.9" /TU="NA" /idTUdmin="U2807" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3176847..3178220) /gene="ywtG" /locus_tag="BSU_35830" /old_locus_tag="BSU35830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carbohydrate/proton transporter" /protein_id="NP_391464.2" /db_xref="EnsemblGenomes-Gn:BSU35830" /db_xref="EnsemblGenomes-Tr:CAB15600" /db_xref="GOA:C0SPB2" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12538" /db_xref="UniProtKB/Swiss-Prot:C0SPB2" /translation="MKKQSNIWLYFFGALGGALYGYDTGVISGAILFMKKELGLNAFT EGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLF RIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEA WRWMLGLAAVPSLLLLIGILFMPESPRWLFTNGEESKAKKILEKLRGTKDIDQEIHDI KEAEKQDEGGLKELFDPWVRPALIAGLGLAFLQQFIGTNTIIYYAPKTFTNVGFGNSA SILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALVNLFFDNTPA ASWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLT YPILMEAIGISYLFLIYAAIGIMAFLFVRFKVTETKGRSLEEIEQDLRDKNGQGGAAG KQQTVGT*" /label="ywtG CDS" gene complement(3176847..3178220) /gene="ywtG" /locus_tag="BSU_35830" /old_locus_tag="BSU35830" /label="ywtG gene" downshifts complement(3176852) /Source="Nicolas_upshifts" /id="D1852" /incds=0 /nref=13 /ntot=90 /MaxReadThrough="6.08746" /MaxDrop="3.99424" /score="22.7548183" /energy="-16.7" /TU="U2808" /idTUdmin="U2808" /TUdmin="-900" /isTUend="FALSE" /label="downshifts" S_feature complement(3178221..3178284) /Source="Nicolas_S_feature" /locus_tag="new_3693907_3693970_c" /HighExp="Etha, Salt, Gly, Heat, Sw, LPhT, HiTm, Diami, B60, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1379" promotor_-10 complement(3178272..3178290) /Source="Nicolas_upshift_promotors" /id="U2808" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=188 /SigmaFactorBS="atgattggaaaacttatgatcagaaaaataaaaaGGTTTAAt ggccggaaaaagaGGCTAAAAGATTTCTAAAAaaatcccacagacaatgtcattgcag c" /listShort="S1379, ywtG, S1378" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3178285) /Source="Nicolas_upshifts" /id="U2808" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=188 /SigmaFactorBS="atgattggaaaacttatgatcagaaaaataaaaaGGTTTAAt ggccggaaaaagaGGCTAAAAGATTTCTAAAAaaatcccacagacaatgtcattgcag c" /listShort="S1379, ywtG, S1378" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3178305..3178311) /Source="Nicolas_upshift_promotors" /id="U2808" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=188 /SigmaFactorBS="atgattggaaaacttatgatcagaaaaataaaaaGGTTTAAt ggccggaaaaagaGGCTAAAAGATTTCTAAAAaaatcccacagacaatgtcattgcag c" /listShort="S1379, ywtG, S1378" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3178371..3178380 /Source="Nicolas_upshift_promotors" /id="U2809" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1659 /SigmaFactorBS="ttttccaatcatttacttgtatttttttcaatgtcgcCGAAA CATTTtacctgctgcgGCGTCCAATATAAGGTgattcagtacattatcgttatcaatt t" /listShort="S1380, ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3178392..3178407 /Source="Nicolas_upshift_promotors" /id="U2809" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1659 /SigmaFactorBS="ttttccaatcatttacttgtatttttttcaatgtcgcCGAAA CATTTtacctgctgcgGCGTCCAATATAAGGTgattcagtacattatcgttatcaatt t" /listShort="S1380, ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3178394..3178514 /Source="Nicolas_S_feature" /locus_tag="new_3694080_3694200" /HighExp="T-0.40H, LBGstat, T-1.10H, T0.30H, Heat, T-1.40H, T1.30H, T1.0H, T0.0H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1380" upshifts 3178394 /Source="Nicolas_upshifts" /id="U2809" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1659 /SigmaFactorBS="ttttccaatcatttacttgtatttttttcaatgtcgcCGAAA CATTTtacctgctgcgGCGTCCAATATAAGGTgattcagtacattatcgttatcaatt t" /listShort="S1380, ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3178489..3178496 /Source="Nicolas_upshift_promotors" /id="U2810" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58041958041958" /psig="0.997002997002997" /xcortree=2249 /SigmaFactorBS="tataggaatatttatcgaaaaatgtctttcgagTAGTTGCCc catggcaaatagAATGGTACGCTTCAAATATTaaagaaacgtgaggtattgatatatg g" /listShort="ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3178510..3178529 /Source="Nicolas_upshift_promotors" /id="U2810" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58041958041958" /psig="0.997002997002997" /xcortree=2249 /SigmaFactorBS="tataggaatatttatcgaaaaatgtctttcgagTAGTTGCCc catggcaaatagAATGGTACGCTTCAAATATTaaagaaacgtgaggtattgatatatg g" /listShort="ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3178516 /Source="Nicolas_upshifts" /id="U2810" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58041958041958" /psig="0.997002997002997" /xcortree=2249 /SigmaFactorBS="tataggaatatttatcgaaaaatgtctttcgagTAGTTGCCc catggcaaatagAATGGTACGCTTCAAATATTaaagaaacgtgaggtattgatatatg g" /listShort="ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="upshifts" CDS 3178553..3179521 /gene="tagT" /locus_tag="BSU_35840" /old_locus_tag="BSU35840" /function="12: Regulatory functions" /experiment="publication(s) with functional evidences, PMID:19099556, 22432711, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19099556, 22432711, 29107701; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain of capsule synthesis" /protein_id="NP_391465.2" /db_xref="EnsemblGenomes-Gn:BSU35840" /db_xref="EnsemblGenomes-Tr:CAB15601" /db_xref="GOA:Q7WY78" /db_xref="InterPro:IPR004474" /db_xref="PDB:3MEJ" /db_xref="PDB:4DE9" /db_xref="SubtiList:BG12537" /db_xref="UniProtKB/Swiss-Prot:Q7WY78" /translation="MEERSQRRKKKRKLKKWVKVVAGLMAFLVIAAGSVGAYAFVKLN NASKEAHVSLARGEQSVKRIKEFDPGKDSFSVLLLGIDAREKNGETVDQARSDANVLV TFNRKEKTAKMLSIPRDAYVNIPGHGYDKFTHAHAYGGVDLTVKTVEEMLDIPVDYVV ESNFTAFEDVVNELNGVKVTVKSDKVIQQIKKDTKGKVVLQKGTHTLDGEEALAYVRT RKADSDLLRGQRQMEVLSAIIDKSKSLSSIPAYDDIVDTMGQNLKMNLSLKDAIGLFP FITSLKSVESIQLTGYDYEPAGVYYFKLNQQKLQEVKKELQNDLGV*" /label="tagT CDS" gene 3178553..3179521 /gene="tagT" /locus_tag="BSU_35840" /old_locus_tag="BSU35840" /label="tagT gene" downshifts 3179506 /Source="Nicolas_upshifts" /id="D1853" /incds=0 /nref=27 /ntot=139 /MaxReadThrough="6.07699" /MaxDrop="4.78541" /score="17.3040761" /energy="-17.8" /TU="U2809,U2810" /idTUdmin="U2809" /TUdmin="-1012" /isTUend="FALSE" /label="downshifts" promotor_-35 3179565..3179572 /Source="Nicolas_upshift_promotors" /id="U2811" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.982017982017982" /xcortree=1778 /SigmaFactorBS="cgattacgccatcccgttttacatatttcctTGTTGAAAatt atcaaagtaacGTTTAGCCTTAATTTATATGgattatgtttcacaggcaagctgaaca t" /listShort="S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3179587..3179606 /Source="Nicolas_upshift_promotors" /id="U2811" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.982017982017982" /xcortree=1778 /SigmaFactorBS="cgattacgccatcccgttttacatatttcctTGTTGAAAatt atcaaagtaacGTTTAGCCTTAATTTATATGgattatgtttcacaggcaagctgaaca t" /listShort="S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3179594..3179676 /Source="Nicolas_S_feature" /locus_tag="new_3695280_3695362" /HighExp="Etha, dia5, Lbtran, dia15, LBGexp, LBGtran, G150, Mt0, G180, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="0.982, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1381" upshifts 3179594 /Source="Nicolas_upshifts" /id="U2811" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.982017982017982" /xcortree=1778 /SigmaFactorBS="cgattacgccatcccgttttacatatttcctTGTTGAAAatt atcaaagtaacGTTTAGCCTTAATTTATATGgattatgtttcacaggcaagctgaaca t" /listShort="S1381, ywtE" /GFF_Attribute="listLong" /label="upshifts" CDS 3179677..3180537 /gene="ribZB" /locus_tag="BSU_35850" /old_locus_tag="BSU35850" /EC_number="3.1.3.-" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 26316208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase (promiscuous activity)" /protein_id="NP_391466.1" /db_xref="EnsemblGenomes-Gn:BSU35850" /db_xref="EnsemblGenomes-Tr:CAB15602" /db_xref="GOA:P96741" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12536" /db_xref="UniProtKB/Swiss-Prot:P96741" /translation="MKCIAIDLDGTLLNKESVISAENREAIKRAVDAGILVTICTGRA TFDVKALLDDLDIPIIAANGGTIHDTGYRLISRTLMDQEAGKAIADYLLSKNIYFEVY TDDHLLSPFDGEAKLHAELDILKSANPNEQTDDLWQGAMTQFKQFGIKPIPHIESVFD GGENIYKLLCFSFDMDKLKQAKEELKHHKKLAQTSSGKHIIEILPASSGKGRALTKLA DIYGIETQDIYAIGDSPNDLSMFEVAGHRIAMENAIDELKEKSTFVTKSNDENGVAYF IDQLLSGQYA*" /label="ribZB CDS" gene 3179677..3180537 /gene="ribZB" /locus_tag="BSU_35850" /old_locus_tag="BSU35850" /label="ribZB gene" downshifts 3180518 /Source="Nicolas_upshifts" /id="D1854" /incds=0 /nref=163 /ntot=235 /MaxReadThrough="3.35965" /MaxDrop="5.65658" /score="24.125299" /energy="-9.8" /TU="NA" /idTUdmin="U2809" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3180571..3181812) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /EC_number="3.4.19.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12073126, 12644511, 16689787, 16952838, 26158264, 28664519" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073126, 12644511, 16689787, 16952838, 26158264, 28664519; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-DD-glutamyl hydrolase (PGA depolymerase)" /protein_id="NP_391467.1" /db_xref="EnsemblGenomes-Gn:BSU35860" /db_xref="EnsemblGenomes-Tr:CAB15603" /db_xref="GOA:P96740" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG12535" /db_xref="UniProtKB/Swiss-Prot:P96740" /translation="MNTLANWKKFLLVAVIICFLVPIMTKAEIAEADTSSELIVSEAK NLLGYQYKYGGETPKEGFDPSGLIQYVFSKADIHLPRSVNDQYKIGTAVKPENLKPGD ILFFKKEGSTGTVPTHDALYIGDGQMVHSTQSKGVIITNYKKSSYWSGTYIGARRIAA DPATADVPVVQEAEKYIGVPYVFGGSTPSEGFDCSGLVQYVFQQALGIYLPRSAEQQW AVGEKVAPQNIKPGDVVYFSNTYKTGISHAGIYAGAGRFIQASRSEKVTISYLSEDYW KSKMTGIRRFDNLTIPKENPIVSEATLYVGEVPYKQGGVTPETGFDTAGFVQYVYQKA AGISLPRYATSQYNAGTKIEKADLKPGDIVFFQSTSLNPSIYIGNGQVVHVTLSNGVT ITNMNTSTYWKDKYAGSIRVQ*" /label="pgdS CDS" gene complement(3180571..3181812) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /label="pgdS gene" downshifts complement(3180590) /Source="Nicolas_upshifts" /id="D1855" /incds=0 /nref=228 /ntot=317 /MaxReadThrough="2.27329" /MaxDrop="7.15996" /score="10.2499259" /energy="-9.8" /TU="NA" /idTUdmin="U2812" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3181834..3181852) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3181856) /Source="Nicolas_upshifts" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3181865..3181872) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3181953..3182120) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16267300, 16689787, 20812257, 21357437, 23583563, 25843804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267300, 16689787, 20812257, 21357437, 23583563, 25843804; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor required extrachromosomal elements maintenance" /protein_id="NP_391468.1" /db_xref="EnsemblGenomes-Gn:BSU35870" /db_xref="EnsemblGenomes-Tr:CAB15604" /db_xref="SubtiList:BG12534" /db_xref="UniProtKB/Swiss-Prot:P96739" /translation="MKFVKAIWPFVAVAIVFMFMSAFKFNDQLTDQEKQKIDMEMNKI QQQEEPVNANK*" /label="edmS CDS" gene complement(3181953..3182120) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /label="edmS gene" downshifts complement(3181980) /Source="Nicolas_upshifts" /id="D1856" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="0.6752" /MaxDrop="2.78178" /score="24.9141523" /energy="-14.7" /TU="NA" /idTUdmin="U2812" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" CDS complement(3182135..3183277) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /EC_number="6.3.2.-" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 12644511, 16689787, 19745567, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 12644511, 16689787, 19745567, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (acid resistance)" /protein_id="NP_391469.1" /db_xref="EnsemblGenomes-Gn:BSU35880" /db_xref="EnsemblGenomes-Tr:CAB15605" /db_xref="InterPro:IPR019079" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12533" /db_xref="UniProtKB/Swiss-Prot:P96738" /translation="MKKELSFHEKLLKLTKQQKKKTNKHVFIAIPIVFVLMFAFMWAG KAETPKVKTYSDDVLSASFVGDIMMGRYVEKVTEQKGADSIFQYVEPIFRASDYVAGN FENPVTYQKNYKQADKEIHLQTNKESVKVLKDMNFTVLNSANNHAMDYGVQGMKDTLG EFAKQNLDIVGAGYSLSDAKKKISYQKVNGVTIATLGFTDVSGKGFAAKKNTPGVLPA DPEIFIPMISEAKKHADIVVVQSHWGQEYDNDPNDRQRQLARAMSDAGADIIVGHHPH VLEPIEVYNGTVIFYSLGNFVFDQGWTRTRDSALVQYHLKKNGTGRFEVTPIDIHEAT PAPVKKDSLKQKTIIRELTKDSNFAWKVEDGKLTFDIDHSDKLKSK*" /label="capA CDS" gene complement(3182135..3183277) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /label="capA gene" CDS complement(3183296..3183745) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 15849754, 16689787, 16850406, 19734658" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 15849754, 16689787, 16850406, 19734658; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate amide ligase/translocase subunit" /protein_id="NP_391470.1" /db_xref="EnsemblGenomes-Gn:BSU35890" /db_xref="EnsemblGenomes-Tr:CAB15606" /db_xref="GOA:P96737" /db_xref="InterPro:IPR008338" /db_xref="SubtiList:BG12532" /db_xref="UniProtKB/Swiss-Prot:P96737" /translation="MFGSDLYIALILGVLLSLIFAEKTGIVPAGLVVPGYLGLVFNQP VFILLVLLVSLLTYVIVKYGLSKFMILYGRRKFAAMLITGIVLKIAFDFLYPIVPFEI AEFRGIGIIVPGLIANTIQKQGLTITFGSTLLLSGATFAIMFVYYLI*" /label="capC CDS" gene complement(3183296..3183745) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /label="capC gene" promotor_-35 3183439..3183445 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-35" upshifts 3183453 /Source="Nicolas_upshifts" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="upshifts" promotor_-10 3183459..3183477 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-10" S_feature 3183466..3185675 /Source="Nicolas_S_feature" /locus_tag="new_3699152_3701361" /HighExp="Sw, Salt, dia5, BC, B60, Diami, Lbstat, H2O2, dia15, Gly" /AntisenseName="pgsB" /AntisenseCor="7.6745622610153399E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="0.40410200000000002" /TUshortSig="SigB" /TUshortPSig="0.853" /TUlongSig="NA" /TUlongPSig="NA" /label="S1382" CDS complement(3183760..3184941) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11606194, 11751809, 12644511, 16689787, 19420703, 19734658, 27446033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (ATP-dependentamide ligase)" /protein_id="NP_391471.2" /db_xref="EnsemblGenomes-Gn:BSU35900" /db_xref="EnsemblGenomes-Tr:CAB15607" /db_xref="GOA:P96736" /db_xref="InterPro:IPR008337" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="SubtiList:BG12531" /db_xref="UniProtKB/Swiss-Prot:P96736" /translation="MWLLIIACAVILVIGILEKRRHQKNIDALPVRVNINGIRGKSTV TRLTTGILIEAGYKTVGKTTGTDARMIYWDTPEEKPIKRKPQGPNIGEQKEVMRETVE RGANAIVSECMAVNPDYQIIFQEELLQANIGVIVNVLEDHMDVMGPTLDEIAEAFTAT IPYNGHLVITDSEYTEFFKQKAKERNTKVIIADNSKITDEYLRKFEYMVFPDNASLAL GVAQALGIDEETAFKGMLNAPPDPGAMRILPLISPSEPGHFVNGFAANDASSTLNIWK RVKEIGYPTDDPIIIMNCRADRVDRTQQFANDVLPYIEASELILIGETTEPIVKAYEE GKIPADKLHDLEYKSTDEIMELLKKRMHNRVIYGVGNIHGAAEPLIEKIHEYKVKQLV S*" /label="capB CDS" gene complement(3183760..3184941) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /label="capB gene" promotor_-35 3185655..3185662 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3185677 /Source="Nicolas_upshifts" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3185678..3185697 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3185698) /Source="Nicolas_upshifts" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3185703..3185717) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3185725..3185729) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3185725..3186705 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11750820, 16519689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11750820, 16519689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="ribose operon repressor (LacI family, D-ribose)" /protein_id="NP_391472.1" /db_xref="EnsemblGenomes-Gn:BSU35910" /db_xref="EnsemblGenomes-Tr:CAB15608" /db_xref="GOA:P36944" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10876" /db_xref="UniProtKB/Swiss-Prot:P36944" /translation="MATIKDVAGAAGVSVATVSRNLNDNGYVHEETRTRVIAAMAKLN YYPNEVARSLYKRESRLIGLLLPDITNPFFPQLARGAEDELNREGYRLIFGNSDEELK KELEYLQTFKQNHVAGIIAATNYPDLEEYSGMNYPVVFLDRTLEGAPSVSSDGYTGVK LAAQAIIHGKSQRITLLRGPAHLPTAQDRFNGALEILKQAEVDFQVIETASFSIKDAQ SMAKELFASYPATDGVIASNDIQAAAVLHEALRRGKNVPEDIQIIGYDDIPQSGLLFP PLSTIKQPAYDMGKEAAKLLLGIIKKQPLAETAIQMPVTYIGRKTTRKED*" /label="rbsR CDS" gene 3185725..3186705 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /label="rbsR gene" promotor_-35 3186554..3186561 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3186575..3186594 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3186590 /Source="Nicolas_upshifts" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="upshifts" CDS 3186707..3187588 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /EC_number="2.7.1.15" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 16978644; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribokinase" /protein_id="NP_391473.1" /db_xref="EnsemblGenomes-Gn:BSU35920" /db_xref="EnsemblGenomes-Tr:CAB15609" /db_xref="GOA:P36945" /db_xref="InterPro:IPR002139" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR011877" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG10877" /db_xref="UniProtKB/Swiss-Prot:P36945" /translation="MRNICVIGSCSMDLVVTSDKRPKAGETVLGTSFQTVPGGKGANQ AVAAARLGAQVFMVGKVGDDHYGTAILNNLKANGVRTDYMEPVTHTESGTAHIVLAEG DNSIVVVKGANDDITPAYALNALEQIEKVDMVLIQQEIPEETVDEVCKYCHSHDIPII LNPAPARPLKQETIDHATYLTPNEHEASILFPELTISEALALYPAKLFITEGKQGVRY SAGSKEVLIPSFPVEPVDTTGAGDTFNAAFAVALAEGKDIEAALRFANRAASLSVCSF GAQGGMPTRNEVEELLS*" /label="rbsK CDS" gene 3186707..3187588 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /label="rbsK gene" CDS 3187585..3187980 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /EC_number="5.4.99.62" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 12738765, 21276853; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose pyranase" /protein_id="NP_391474.1" /db_xref="EnsemblGenomes-Gn:BSU35930" /db_xref="EnsemblGenomes-Tr:CAB15610" /db_xref="GOA:P36946" /db_xref="InterPro:IPR007721" /db_xref="InterPro:IPR023064" /db_xref="InterPro:IPR023750" /db_xref="PDB:1OGC" /db_xref="PDB:1OGD" /db_xref="PDB:1OGE" /db_xref="PDB:1OGF" /db_xref="SubtiList:BG10878" /db_xref="UniProtKB/Swiss-Prot:P36946" /translation="MKKHGILNSHLAKILADLGHTDKIVIADAGLPVPDGVLKIDLSL KPGLPAFQDTAAVLAEEMAVEKVIAAAEIKASNQENAKFLENLFSEQEIEYLSHEEFK LLTKDAKAVIRTGEFTPYANCILQAGVLF*" /label="rbsD CDS" gene 3187585..3187980 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /label="rbsD gene" CDS 3187996..3189477 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ATP-binding protein)" /protein_id="NP_391475.1" /db_xref="EnsemblGenomes-Gn:BSU35940" /db_xref="EnsemblGenomes-Tr:CAB15611" /db_xref="GOA:P36947" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015861" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10879" /db_xref="UniProtKB/Swiss-Prot:P36947" /translation="MQIEMKDIHKTFGKNQVLSGVSFQLMPGEVHALMGENGAGKSTL MNILTGLHKADKGQISINGNETYFSNPKEAEQHGIAFIHQELNIWPEMTVLENLFIGK EISSKLGVLQTRKMKALAKEQFDKLSVSLSLDQEAGECSVGQQQMIEIAKALMTNAEV IIMDEPTAALTEREISKLFEVITALKKNGVSIVYISHRMEEIFAICDRITIMRDGKTV DTTNISETDFDEVVKKMVGRELTERYPKRTPSLGDKVFEVKNASVKGSFEDVSFYVRS GEIVGVSGLMGAGRTEMMRALFGVDRLDTGEIWIAGKKTAIKNPQEAVKKGLGFITEN RKDEGLLLDTSIRENIALPNLSSFSPKGLIDHKREAEFVDLLIKRLTIKTASPETHAR HLSGGNQQKVVIAKWIGIGPKVLILDEPTRGVDVGAKREIYTLMNELTERGVAIIMVS SELPEILGMSDRIIVVHEGRISGEIHAREATQERIMTLATGGR*" /label="rbsA CDS" gene 3187996..3189477 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /label="rbsA gene" CDS 3189479..3190447 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (permease)" /protein_id="NP_391476.1" /db_xref="EnsemblGenomes-Gn:BSU35950" /db_xref="EnsemblGenomes-Tr:CAB15612" /db_xref="GOA:P36948" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10880" /db_xref="UniProtKB/Swiss-Prot:P36948" /translation="MKTEQLQTEQKRIHFDGVMQKLGPFLGLFILVIIVSILNPSFLE PLNILNLLRQVAINGLIAFGMTFVILTGGIDLSVGAILALSSALVAGMIVSGVDPVLA IILGCIIGAVLGMINGLLITKGKMAPFIATLATMTVFRGLTLVYTDGNPITGLGTNYG FQMFGRGYFLGIPVPAITMVLAFVILWVLLHKTPFGRRTYAIGGNEKAALISGIKVTR VKVMIYSLAGLLSALAGAILTSRLHSAQPTAGESYELDAIAAVVLGGTSLSGGRGRIV GTLIGVLIIGTLNNGLNLLGVSSFYQLVVKGIVILIAVLLDRKKSA*" /label="rbsC CDS" gene 3189479..3190447 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /label="rbsC gene" CDS 3190459..3191376 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ribose-binding lipoprotein)" /protein_id="NP_391477.1" /db_xref="EnsemblGenomes-Gn:BSU35960" /db_xref="EnsemblGenomes-Tr:CAB15613" /db_xref="GOA:P36949" /db_xref="InterPro:IPR025997" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10881" /db_xref="UniProtKB/Swiss-Prot:P36949" /translation="MKKAVSVILTLSLFLLTACSLEPPQWAKPSNSGNKKEFTIGLSV STLNNPFFVSLKKGIEKEAKKRGMKVIIVDAQNDSSKQTSDVEDLIQQGVDALLINPT DSSAISTAVESANAVGVPVVTIDRSAEQGKVETLVASDNVKGGEMAAAFIADKLGKGA KVAELEGVPGASATRERGSGFHNIADQKLQVVTKQSADFDRTKGLTVMENLLQGHPDI QAVFAHNDEMALGALEAINSSGKDILVIGFDGNKDALASIKDRKLSATVAQQPELIGK LATEAADDILHGKKVQKTISAPLKLETQK*" /label="rbsB CDS" gene 3190459..3191376 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /label="rbsB gene" promotor_-35 3191385..3191391 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3191406..3191424 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3191408 /Source="Nicolas_upshifts" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="upshifts" CDS 3191458..3191994 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall binding enzyme" /protein_id="NP_391478.1" /db_xref="EnsemblGenomes-Gn:BSU35970" /db_xref="EnsemblGenomes-Tr:CAB15614" /db_xref="GOA:P96729" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR036028" /db_xref="SubtiList:BG12530" /db_xref="UniProtKB/Swiss-Prot:P96729" /translation="MNKPTKLFSTLALAAGMTAAAAGGAGTIHAQQPETTVSIDDLYS YPIDSYLVSAEALNVRTKPSASSQKADTLHLGDSLKLISFSNADWAKVKYKNGKTGFV STHYIVKAATTVKTKTKTKVYTSADGKSIKTLPADTSVSFLGWSKTNKGGFDFDWVFV DYGGTTGYMKTKDLHMTK*" /label="ywsB CDS" gene 3191458..3191994 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /label="ywsB gene" downshifts 3191977 /Source="Nicolas_upshifts" /id="D1857" /incds=0 /nref=187 /ntot=255 /MaxReadThrough="5.87246" /MaxDrop="7.38203" /score="26.4284327" /energy="-19" /TU="U2817" /idTUdmin="U2814" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" S_feature 3192022..3192132 /Source="Nicolas_S_feature" /locus_tag="new_3707708_3707818" /HighExp="Etha, M9-stat, Sw, M40t90, G150, B60, T0.30H, M0t90, T1.30H, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1383" promotor_-35 3192101..3192107 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3192122..3192133 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3192134 /Source="Nicolas_upshifts" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="upshifts" CDS 3192150..3192446 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11782522" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391479.1" /db_xref="EnsemblGenomes-Gn:BSU35980" /db_xref="EnsemblGenomes-Tr:CAB15615" /db_xref="InterPro:IPR024997" /db_xref="SubtiList:BG12529" /db_xref="UniProtKB/Swiss-Prot:P96728" /translation="MDQFEAAYESYKARQTTADQENVPSGKEEIIAVRRNEEDNIIAV KTNTGRELDYPTALSEAKSGKLAHVDVFHKYGRDILRSEPDGIKENNLSELPDF*" /label="ywsA CDS" gene 3192150..3192446 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /label="ywsA gene" S_feature 3192447..3193099 /Source="Nicolas_S_feature" /locus_tag="new_3708133_3708785" /HighExp="Etha, M9-stat, S5, S7, S6, Sw, S8, B60, G150, S4" /AntisenseName="ywrO" /AntisenseCor="-0.23279201478213099" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1384" CDS complement(3192486..3193013) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11782522, 14697229, 17768344; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitroreductase (unknown substrate)" /protein_id="NP_391480.1" /db_xref="EnsemblGenomes-Gn:BSU35990" /db_xref="EnsemblGenomes-Tr:CAB15616" /db_xref="GOA:P80871" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12528" /db_xref="UniProtKB/Swiss-Prot:P80871" /translation="MKILVLAVHPHMETSVVNKAWAEELSKHDNITVRDLYKEYPDEA IDVAKEQQLCEEYDRIVFQFPLYWYSSPPLLKKWQDLVLTYGWAFGSEGNALHGKELM LAVSTGSEAEKYQAGGANHYSISELLKPFQATSNLIGMKYLPPYVFYGVNYAAAEDIS HSAKRLAEYIQQPFV*" /label="ywrO CDS" gene complement(3192486..3193013) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /label="ywrO gene" downshifts complement(3192496) /Source="Nicolas_upshifts" /id="D1858" /incds=0 /nref=48 /ntot=208 /MaxReadThrough="3.48831" /MaxDrop="4.56453" /score="1.41593376" /energy="-17.4" /TU="U2819" /idTUdmin="U2821" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3193033..3193052) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3193046) /Source="Nicolas_upshifts" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="upshifts" downshifts 3193057 /Source="Nicolas_upshifts" /id="D1859" /incds=0 /nref=26 /ntot=56 /MaxReadThrough="0.805200000000001" /MaxDrop="4.7199" /score="10.409416" /energy="-6.8" /TU="NA" /idTUdmin="U2817" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3193066..3193073) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3193112) /Source="Nicolas_upshifts" /id="D1860" /incds=0 /nref=20 /ntot=149 /MaxReadThrough="4.85403" /MaxDrop="6.46739" /score="-8.02974492" /energy="-5" /TU="U2821" /idTUdmin="U2821" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" CDS complement(3193113..3193880) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /EC_number="4.1.1.5" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7685336, 10972805, 12363365, 17183216, 21531833, 26454865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7685336, 10972805, 12363365, 17183216, 21531833, 26454865; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate decarboxylase" /protein_id="NP_391481.1" /db_xref="EnsemblGenomes-Gn:BSU36000" /db_xref="EnsemblGenomes-Tr:CAB15617" /db_xref="GOA:Q04777" /db_xref="InterPro:IPR005128" /db_xref="SubtiList:BG10472" /db_xref="UniProtKB/Swiss-Prot:Q04777" /translation="MKRESNIQVLSRGQKDQPVSQIYQVSTMTSLLDGVYDGDFELSE IPKYGDFGIGTFNKLDGELIGFDGEFYRLRSDGTATPVQNGDRSPFCSFTFFTPDMTH KIDAKMTREDFEKEINSMLPSRNLFYAIRIDGLFKKVQTRTVELQEKPYVPMVEAVKT QPIFNFDNVRGTIVGFLTPAYANGIAVSGYHLHFIDEGRNSGGHVFDYVLEDCTVTIS QKMNMNLRLPNTADFFNANLDNPDFAKDIETTEGSPE*" /label="alsD CDS" gene complement(3193113..3193880) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /label="alsD gene" CDS complement(3193942..3195654) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /EC_number="2.2.1.6" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972805, 12363365, 17183216, 7685336, 25393087, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972805, 12363365, 17183216, 7685336, 25393087, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate synthase" /protein_id="NP_391482.2" /db_xref="EnsemblGenomes-Gn:BSU36010" /db_xref="EnsemblGenomes-Tr:CAB15618" /db_xref="GOA:Q04789" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012782" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10471" /db_xref="UniProtKB/Swiss-Prot:Q04789" /translation="MTKATKEQKSLVKNRGAELVVDCLVEQGVTHVFGIPGAKIDAVF DALQDKGPEIIVARHEQNAAFMAQAVGRLTGKPGVVLVTSGPGASNLATGLLTANTEG DPVVALAGNVIRADRLKRTHQSLDNAALFQPITKYSVEVQDVKNIPEAVTNAFRIASA GQAGAAFVSFPQDVVNEVTNTKNVRAVAAPKLGPAADDAISAAIAKIQTAKLPVVLVG MKGGRPEAIKAVRKLLKKVQLPFVETYQAAGTLSRDLEDQYFGRIGLFRNQPGDLLLE QADVVLTIGYDPIEYDPKFWNINGDRTIIHLDEIIADIDHAYQPDLELIGDIPSTINH IEHDAVKVEFAEREQKILSDLKQYMHEGEQVPADWKSDRAHPLEIVKELRNAVDDHVT VTCDIGSHAIWMSRYFRSYEPLTLMISNGMQTLGVALPWAIGASLVKPGEKVVSVSGD GGFLFSAMELETAVRLKAPIVHIVWNDSTYDMVAFQQLKKYNRTSAVDFGNIDIVKYA ESFGATGLRVESPDQLADVLRQGMNAEGPVIIDVPVDYSDNINLASDKLPKEFGELMK TKAL*" /label="alsS CDS" gene complement(3193942..3195654) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /label="alsS gene" promotor_-35 3194553..3194562 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3194576..3194595 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3194576 /Source="Nicolas_upshifts" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3195708..3195727) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3195713) /Source="Nicolas_upshifts" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3195733..3195740 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3195742..3195746) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3195754..3195773 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3195764 /Source="Nicolas_upshifts" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="upshifts" CDS 3195812..3196720 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling alsSD, ictEP expression (LysR family)" /protein_id="NP_391483.1" /db_xref="EnsemblGenomes-Gn:BSU36020" /db_xref="EnsemblGenomes-Tr:CAB15619" /db_xref="GOA:Q04778" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10470" /db_xref="UniProtKB/Swiss-Prot:Q04778" /translation="MELRHLQYFIAVAEELHFGKAARRLNMTQPPLSQQIKQLEEEVG VTLLKRTKRFVELTAAGEIFLNHCRMALMQIGQGIELAQRTARGEQGLLVIGFVGSAT YEFLPPIVREYRKKFPSVKIELREISSSRQQEELLKGNIDIGILHPPLQHTALHIETA QSSPCVLALPKQHPLTSKESITIEDLRDEPIITVAKEAWPTLYMDFIQFCEQAGFRPN IVQEATEYQMVIGLVSAGIGMTFVPSSAKKLFNLDVTYRKMDQIQLNAEWVIAYRKDN HNPLIKHFIHISNCQQTRTKESDAGT*" /label="alsR CDS" gene 3195812..3196720 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /label="alsR gene" promotor_-35 3196788..3196796 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3196798..3196930 /Source="Nicolas_S_feature" /locus_tag="new_3712484_3712616" /HighExp="BT, S8, B36, S7, G/S, S6, Pyr, B60, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.14666000000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.896, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1385" upshifts 3196798 /Source="Nicolas_upshifts" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3196810..3196829 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3196931..3198259 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/H+ antiporter" /protein_id="NP_391484.1" /db_xref="EnsemblGenomes-Gn:BSU36030" /db_xref="EnsemblGenomes-Tr:CAB15620" /db_xref="GOA:O05224" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12527" /db_xref="UniProtKB/Swiss-Prot:O05224" /translation="MLAFFVTMIFIFWRPKGLNEAIPATFGALMVLLCGSVSLADLGE IGTKVTGASVTILATMIMAIALESFGFFYWVAAKLLQQSKGSGIKLFWLTNLLCFLMT IFLNNDGSILITTPILLLVLKYLGLKKHQKAPYLLSGVLIATASSAPIGVSNIVNLIS LKIIGMDLYLHTAMMFVPSMMGLIFMTCLLFMFFYKRLPKSLPDIPGHFQSLRHRRYH PLHSPSAPLPERNQTKIMLFVLAFVFLVRMSLFAASYTGISVPLVAVIGSFILLSWRW IYFKTSPRDLLYKSPWHIFIFAFTMYVLIYGLHNIGFTELLVSYFEPVVSGSLAHATF ASGISTSVFSNLFNNHPALMISTFTLTEMTLNPSTTKIIYLANIIGSDIGSLLLPMGT LATLIWMHILKQHDESISWGEYIKTTIIIIPLTVLFTLTCLYFWISWLFL*" /label="ywrK CDS" gene 3196931..3198259 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /label="ywrK gene" downshifts 3198250 /Source="Nicolas_upshifts" /id="D1861" /incds=0 /nref=16 /ntot=32 /MaxReadThrough="1.63489" /MaxDrop="6.12455" /score="-6.14091334" /energy="-11.9" /TU="NA" /idTUdmin="U2823" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3198316..3198993) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14762006, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391485.1" /db_xref="EnsemblGenomes-Gn:BSU36040" /db_xref="EnsemblGenomes-Tr:CAB15621" /db_xref="InterPro:IPR020139" /db_xref="InterPro:IPR020173" /db_xref="SubtiList:BG12526" /db_xref="UniProtKB/Swiss-Prot:O05223" /translation="MKGLNQFLNTDVEVVISGDTRFVGTLIDIGQDIFVIFDGCNYLY IPLLHLHQINKAKIVTSTEKPFLINPEDPMIEAETQAFSYRNTLNKVKGQFIEVYVTG GRSIHGYVTNVLNDYIVFFSPVFKILFISMHHLKWFTPYSTEQTPYTLDNSQLPVVPS KVPLVRNFEEQIKKNIGELVIFDMGEVPEKVGLLKGVSNNIIELINASGEPVIWKLNH LKTMHLP*" /label="ywrJ CDS" gene complement(3198316..3198993) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /label="ywrJ gene" downshifts complement(3198326) /Source="Nicolas_upshifts" /id="D1862" /incds=0 /nref=14 /ntot=28 /MaxReadThrough="1.74629" /MaxDrop="5.1172" /score="-4.02447737" /energy="-9.5" /TU="NA" /idTUdmin="U2824" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3199053..3200195) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8755863, 10559171, 11737650, 14762006, 19933362, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755863, 10559171, 11737650, 14762006, 19933362, 27185916; Product type s : structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_391486.1" /db_xref="EnsemblGenomes-Gn:BSU36050" /db_xref="EnsemblGenomes-Tr:CAB15622" /db_xref="GOA:P07789" /db_xref="SubtiList:BG10491" /db_xref="UniProtKB/Swiss-Prot:P07789" /translation="MSKRRMKYHSNNEISYYNFLHSMKDKIVTVYRGGPESKKGKLTA VKSDYIALQAEKKIIYYQLEHVKSITEDTNNSTTTIETEEMLDADDFHSLIGHLINQS VQFNQGGPESKKGRLVWLGDDYAALNTNEDGVVYFNIHHIKSISKHEPDLKIEEQTPV GVLEADDLSEVFKSLTHKWVSINRGGPEAIEGILVDNADGHYTIVKNQEVLRIYPFHI KSISLGPKGSYKKEDQKNEQNQEDNNDKDSNSFISSKSYSSSKSSKRSLKSSDDQSSK SGRSSRSKSSSKSSKRSLKSSDYQSSKSGRSSRSKSSSKSSKRSLKSSDYQSSKSSKR SPRSSDYQSSRSPGYSSSIKSSGKQKEDYSYETIVRTIDYHWKRKF*" /label="cotB CDS" gene complement(3199053..3200195) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /label="cotB gene" promotor_-10 complement(3200232..3200251) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3200240) /Source="Nicolas_upshifts" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3200242..3200322) /Source="Nicolas_S_feature" /locus_tag="new_3715928_3716008_c" /HighExp="S6, S7, S8, S5, BT, B36, S4, G/S, Pyr, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1386" promotor_-35 complement(3200265..3200273) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3200323..3201411) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762006, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762006, 25115591, 27185916; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein kinase" /protein_id="NP_391487.1" /db_xref="EnsemblGenomes-Gn:BSU36060" /db_xref="EnsemblGenomes-Tr:CAB15623" /db_xref="GOA:Q45535" /db_xref="InterPro:IPR014867" /db_xref="SubtiList:BG11791" /db_xref="UniProtKB/Swiss-Prot:Q45535" /translation="MKNQSNLPLYQLFVHPKDLRELKKDIWDDDPVPAVMKVNQKRLD IDIAYRGSHIRDFKKKSYHISFYQPKTFRGAREIHLNAEYKDPSLMRNKLSLDFFSEL GTLSPKAEFAFVKMNGKNEGVYLELESVDEYYLAKRKLADGAIFYAVDDDANFSLMSD LERETKTSLELGYEKKTGTEEDDFYLQDMIFKINTVPKAQFKSEVTKHVDVDKYLRWL AGIVFTSNYDGFVHNYALYRSGETGLFEVIPWDYDATWGRDIHGERMAADYVRIQGFN TLTARILDESEFRKSYKRLLEKTLQSLFTIEYMEPKIMAMYERIRPFVLMDPYKKNDI ERFDREPDVICEYIKNRSQYLKDHLSIL*" /label="cotH CDS" gene complement(3200323..3201411) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /label="cotH gene" S_feature complement(3201412..3201525) /Source="Nicolas_S_feature" /locus_tag="new_3717098_3717211_c" /HighExp="S6, S8, S7, S5, BT, B36, Pyr, G/S, S4, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1387" promotor_-35 3201467..3201476 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3201489..3201508 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3201502 /Source="Nicolas_upshifts" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3201525) /Source="Nicolas_upshifts" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3201529..3201543) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3201552..3201556) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3201552..3202139 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14762006, 15621419, 22720735, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14762006, 15621419, 22720735, 25115591, 27185916; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore morphogenetic protein" /protein_id="NP_391488.1" /db_xref="EnsemblGenomes-Gn:BSU36070" /db_xref="EnsemblGenomes-Tr:CAB15624" /db_xref="GOA:P39801" /db_xref="SubtiList:BG11017" /db_xref="UniProtKB/Swiss-Prot:P39801" /translation="MGHYSHSDIEEAVKSAKKEGLKDYLYQEPHGKKRSHKKSHRTHK KSRSHKKSYCSHKKSRSHKKSFCSHKKSRSHKKSYCSHKKSRSHKKSYRSHKKSRSYK KSYRSYKKSRSYKKSCRSYKKSRSYKKSYCSHKKKSRSYKKSCRTHKKSYRSHKKYYK KPHHHCDDYKRHDDYDSKKEYWKDGNCWVVKKKYK*" /label="cotG CDS" gene 3201552..3202139 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /label="cotG gene" CDS 3201640..3202119 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /function="14.1: Surface structures" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="doubtful CDS (putative in frame frameshift)" /protein_id="YP_009514005.1" /translation="MEKNAVIKSRTALTKNLAAIKNHTALTKNLAVTKNHSVLTKNLA ATKNHTALTRNLAATKNRTVLTKNLAAIKNLTVLTKNLVAIKNLAVLTKNLAATKSLT VLTRKNLAAIRSHAAHTKNLIVPIRNTTKNRTTTATTTKDTMIMTAKKNTGKTAIAG* " /label="doubtful CDS (putative in frame frameshift)" gene 3201640..3202119 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /label="gene" S_feature complement(3202023..3202220) /Source="Nicolas_S_feature" /locus_tag="new_3717709_3717906_c" /HighExp="S5, S6, S4, B60, S3, nit, G/S, SMMPr, S8, ferm" /AntisenseName="cotG" /AntisenseCor="0.60092819988141299" /AntisenseRegPval="-27.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1388" downshifts 3202056 /Source="Nicolas_upshifts" /id="D1863" /incds=1 /nref=1 /ntot=54 /MaxReadThrough="7.80801" /MaxDrop="2.7794" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" downshifts complement(3202066) /Source="Nicolas_upshifts" /id="D1864" /incds=1 /nref=3 /ntot=23 /MaxReadThrough="4.99409" /MaxDrop="6.67733" /score="-1.37249416" /energy="-5.2" /TU="U2827" /idTUdmin="U2824" /TUdmin="-3740" /isTUend="FALSE" /label="downshifts" downshifts 3202125 /Source="Nicolas_upshifts" /id="D1865" /incds=0 /nref=41 /ntot=80 /MaxReadThrough="4.68169" /MaxDrop="5.35584" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-85" /isTUend="FALSE" /label="downshifts" downshifts 3202204 /Source="Nicolas_upshifts" /id="D1866" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="2.30708" /MaxDrop="3.92552" /score="17.1895651" /energy="-10.7" /TU="NA" /idTUdmin="U2825" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3202219..3202238) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3202225) /Source="Nicolas_upshifts" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3202247..3202254 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3202251..3202260) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3202269..3202288 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3202275 /Source="Nicolas_upshifts" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="upshifts" CDS 3202313..3202930 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /EC_number="1.14.13.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-binding monooxygenase" /protein_id="NP_391489.1" /db_xref="EnsemblGenomes-Gn:BSU36080" /db_xref="EnsemblGenomes-Tr:CAB15625" /db_xref="GOA:O05220" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12525" /db_xref="UniProtKB/Swiss-Prot:O05220" /translation="MYIFQADQLSAKDTYKLLSGTVIPRPIAFVTTLSSGGAVNAAPF SFYNVVSSDPPLLSISVNRTEGRQKDTARNAVENGEFVVHVSDEAIIEDINETAASLR PDESELTRTSLHPVESKAVSVPGIKEARVRFECKLERHITFDNDQGITTADLLIGRVV CFHLDEKVYDAEKGYILTDELKPASRLAGNHYAKLGEEFTLIRPS*" /label="ywrF CDS" gene 3202313..3202930 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /label="ywrF gene" S_feature 3202931..3203031 /Source="Nicolas_S_feature" /locus_tag="new_3718617_3718717" /HighExp="Etha, dia5, Diami, dia15, Lbtran, LBGtran, LPhT, M40t45, M40t90, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1389" downshifts 3202988 /Source="Nicolas_upshifts" /id="D1867" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="4.52989" /MaxDrop="4.48979" /score="-1.9002322" /energy="-14.9" /TU="U2828" /idTUdmin="U2828" /TUdmin="-454" /isTUend="FALSE" /label="downshifts" promotor_-35 3203057..3203066 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3203078..3203093 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3203079 /Source="Nicolas_upshifts" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="upshifts" CDS 3203108..3203443 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391490.1" /db_xref="EnsemblGenomes-Gn:BSU36090" /db_xref="EnsemblGenomes-Tr:CAB15626" /db_xref="GOA:O05219" /db_xref="InterPro:IPR025441" /db_xref="SubtiList:BG12524" /db_xref="UniProtKB/Swiss-Prot:O05219" /translation="MTNFWILMLIAITISLASQFFIKKKYGIDKSGWRYKHVSNTHKW IEITLLILFVFSLSFFPVEYLLLLFFIVIDSIRIFMEWHYRPEDKQYMYHIVEVSLMF MLLIYVCTL*" /label="ywrE CDS" gene 3203108..3203443 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /label="ywrE gene" promotor_-10 complement(3203399..3203417) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3203408) /Source="Nicolas_upshifts" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3203432..3203437) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3203442 /Source="Nicolas_upshifts" /id="D1868" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="5.64855" /MaxDrop="3.64569" /score="-1.9002322" /energy="-14.9" /TU="U2829" /idTUdmin="U2828" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3203448..3205025) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /EC_number="3.5.1.126" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12823818, 14762019, 19935659, 27303801, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxamate amidohydrolase" /protein_id="NP_391491.1" /db_xref="EnsemblGenomes-Gn:BSU36100" /db_xref="EnsemblGenomes-Tr:CAB15627" /db_xref="GOA:O05218" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="SubtiList:BG12523" /db_xref="UniProtKB/Swiss-Prot:O05218" /translation="MNKSVIGTKQMVVSPHYLASQAGNRILDKGGNAFDAAVAVSACL AVVYPHMTGLGGDSFWLTFHQETKAVKVYNGSGRSGKNVTRDVYKGKSAIPLRGIDSA ITVPGMVDSWDAVLKEYGRLSLADVLEPARDYAQNGFPVSADQCRHTEKNIELLASTP YTADIFTRRGKAPVPGERFVQKELADSLNLIAEKGRSAFYEGDLAQRIVSHLQNNGSY MTIDDFKAHRGEWAAPVSSDYRGYSVYQAPPNSQGFTGLLTLNILENYDFTQIEHGSF EYYHVLVEALKKSFLDRDAVLTDPAFADIPLERLLDKRYAKQLAEEIGYLAIPAESRP VGSDTAYAAVIDADGNAVSFIQSLYFEFGSAVTAGDTGILLQNRGSFFSLDENHVNTL EPRKRTFHTLMPAMVCKGGKPKILYGTQGGEGQPQTQTAIITRMLDYGMHPQQAISEP RWVWGRTWGEEYEGLRVEGRFTDKTIQKLKDSGHLVEVVGDYDPLMGQAAAIKVDEEG FLQGGADPRGDGAAVGI*" /label="hpxW CDS" gene complement(3203448..3205025) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /label="hpxW gene" S_feature 3203487..3205198 /Source="Nicolas_S_feature" /locus_tag="new_3719173_3720884" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T-0.40H, T0.0H, Salt" /AntisenseName="ywrD" /AntisenseCor="0.153519829066777" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1390" promotor_-35 3205176..3205183 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3205194..3205213 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3205200 /Source="Nicolas_upshifts" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="upshifts" CDS 3205239..3205715 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23989926; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional negative regulator of chromate transport (Lrp/AsnC family)" /protein_id="NP_391492.1" /db_xref="EnsemblGenomes-Gn:BSU36110" /db_xref="EnsemblGenomes-Tr:CAB15628" /db_xref="GOA:O05217" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12522" /db_xref="UniProtKB/Swiss-Prot:O05217" /translation="MSHEYQIPNLVLDETDKQILTILHEEGRISYTDLGKRVDLSRVA VQARINQLIEAGVIEKFTAVINPAKIGIHVSVFFNVEVEPQFLEEVALKLEEEPAVTS LYHMTGPSKLHMHGIFTNDQEMEEFLTKRLYPLRGVVSVDCQMLIKRYKSRMGMKL*" /label="chrS CDS" gene 3205239..3205715 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /label="chrS gene" CDS 3205729..3206322 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit N" /protein_id="NP_391493.1" /db_xref="EnsemblGenomes-Gn:BSU36120" /db_xref="EnsemblGenomes-Tr:CAB15629" /db_xref="GOA:O05216" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12521" /db_xref="UniProtKB/Swiss-Prot:O05216" /translation="MKNHPYRDMTAAMVRTGILGFGGGPSVIPLIRHEAVNKYKWIDD DEFGEILAIANALPGPIATKMAAYLGFKLKGTLGAIVAILAHILPTCLAMVGLFAAVN VLSHSAIVAGMIGAVTPVIAVMLGIMAYEFGQKALKGFGWVTGILFFIIAFIGLQTLQ INPGLVIIIFLAYGAFHFKLKDKITNKHSKDKGMSAS*" /label="chrB CDS" gene 3205729..3206322 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /label="chrB gene" CDS 3206319..3206855 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit C" /protein_id="NP_391494.1" /db_xref="EnsemblGenomes-Gn:BSU36130" /db_xref="EnsemblGenomes-Tr:CAB15630" /db_xref="GOA:O05215" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12520" /db_xref="UniProtKB/Swiss-Prot:O05215" /translation="MISIYLFMAFFIANLLGYGGGPASIPLMFEEVVNRYSWLSNDQF SNMLALANALPGPIATKIAAYVGYSAGGWPGFLIALIATVVPSALALIVLLRIIQRFR QSPVIKGMTLSVQPVIAVMMLILTWQIGADGIKAIGWVQSIVITGISLLAMTKFKMHP AFLIIAAFLYGGLVIPYL*" /label="chrA CDS" gene 3206319..3206855 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /label="chrA gene" downshifts 3206836 /Source="Nicolas_upshifts" /id="D1869" /incds=0 /nref=4 /ntot=90 /MaxReadThrough="0.0513700000000004" /MaxDrop="3.46649" /score="29.5508265" /energy="-8.6" /TU="NA" /idTUdmin="U2829" /TUdmin=28 /isTUend="FALSE" /label="downshifts" CDS complement(3206882..3207103) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391495.1" /db_xref="EnsemblGenomes-Gn:BSU36140" /db_xref="EnsemblGenomes-Tr:CAB15631" /db_xref="SubtiList:BG12519" /db_xref="UniProtKB/Swiss-Prot:P96727" /translation="MKFLLSVIAGLLILALYLFWKVQPPVWIQVETNSSQLKQSVRMA GTTLQVKHMIKSDAGEETAVISNGISGLK*" /label="ywqO CDS" gene complement(3206882..3207103) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /label="ywqO gene" upshifts 3207050 /Source="Nicolas_upshifts" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3207057..3207058 /Source="Nicolas_upshift_promotors" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3207100..3207645) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391496.1" /db_xref="EnsemblGenomes-Gn:BSU36150" /db_xref="EnsemblGenomes-Tr:CAB15632" /db_xref="GOA:P96726" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLI" /db_xref="SubtiList:BG12518" /db_xref="UniProtKB/Swiss-Prot:P96726" /translation="MKIAVINGGTRSGGNTDVLAEKAVQGFDAEHIYLQKYPIQPIED LRHAQGGFRPVQDDYDSIIERILQCHILIFATPIYWFGMSGTLKLFIDRWSQTLRDPR FPDFKQQMSVKQAYVIAVGGDNPKIKGLPLIQQFEHIFHFMGMSFKGYVLGEGNRPGD ILRDHQALSAASRLLKRSDAI*" /label="ywqN CDS" gene complement(3207100..3207645) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /label="ywqN gene" promotor_-35 3207662..3207669 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3207684..3207703 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3207688 /Source="Nicolas_upshifts" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="upshifts" CDS 3207768..3208649 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391497.1" /db_xref="EnsemblGenomes-Gn:BSU36160" /db_xref="EnsemblGenomes-Tr:CAB15633" /db_xref="GOA:P96725" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12517" /db_xref="UniProtKB/Swiss-Prot:P96725" /translation="MELKQLITFITAAEHVNFTLTAKMLNYAQSSVTSQIKSLEEEIG TPLFERLGKRLILTEAGKTFKSYAQKIIALTEEAKMATNQVRETTGTLKIGATESQCT YRLPPIIKEFKQAFPQVKLIFKPYISNEQAKEQLLQGQLDITFILDVNRMEDALHVES LIQDEIKMVAANDHPFPADLPVTLKDLQNETLLLTEDGCSYRTLFENNLHDSGIYPNK LEFVSIEAIKQCVMAGLGIGILPEMTVKDDIAAGRMKELNWQSDCPVFTQLAWHKDKW MSAPLKAFIDLTRKTFK*" /label="ywqM CDS" gene 3207768..3208649 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /label="ywqM gene" CDS complement(3208734..3209450) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /EC_number="3.1.21.7" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1692969, 22056936, 27530626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1692969, 22056936, 27530626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease V" /protein_id="NP_391498.2" /db_xref="EnsemblGenomes-Gn:BSU36170" /db_xref="EnsemblGenomes-Tr:CAB15634" /db_xref="GOA:P96724" /db_xref="InterPro:IPR007581" /db_xref="PDB:3GA2" /db_xref="SubtiList:BG12516" /db_xref="UniProtKB/Swiss-Prot:P96724" /translation="MKVFDVHKFDMKKEQDFLQVQFNLKNRINLSPTIHPDSINTCAG VDLAYWEQDGEPYGVCCIIVIDADTKEVIEKVHSMGRISVPYVSGFLAFRELPLIIEA AKKLETEPDVFLFDGNGYLHYNHMGVATHAAFFLGKPTIGIAKTYLKIKGCDFVTPEI EVGAYTDIIIDGEVYGRALRTRRDVKPIFLSCGNYIDLDSSYQITMSLINQESRLPIP VRLADLETHVLRTFYQKNHV*" /label="nfi CDS" gene complement(3208734..3209450) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /label="nfi gene" downshifts complement(3208754) /Source="Nicolas_upshifts" /id="D1870" /incds=0 /nref=44 /ntot=216 /MaxReadThrough="1.91774" /MaxDrop="3.62442" /score="12.1019223" /energy="-7.4" /TU="NA" /idTUdmin="U2834" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3209460..3209924) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease antitoxin" /protein_id="NP_391499.1" /db_xref="EnsemblGenomes-Gn:BSU36180" /db_xref="EnsemblGenomes-Tr:CAB15635" /db_xref="InterPro:IPR011652" /db_xref="SubtiList:BG12515" /db_xref="UniProtKB/Swiss-Prot:P96723" /translation="MENEYDMKSIKEKGVDFEDLWFSSVSDEILDNPEDENGQPFTGL AYELYPNGQIIYFTKYKNGLAHGLTCEFYENGNKKSEKEYRYGQLHGISIIWFENGRK KSEQQYEHSILISEKNWDEEGNLLNKYEIDTDSPHFEILESRRETHINLGRE*" /label="rttO CDS" gene complement(3209460..3209924) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /label="rttO gene" CDS complement(3209914..3211722) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /EC_number="3.1.-.-" /function="15.8: Toxin production and resistance" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease toxin" /protein_id="NP_391500.1" /db_xref="EnsemblGenomes-Gn:BSU36190" /db_xref="EnsemblGenomes-Tr:CAB15636" /db_xref="GOA:P96722" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR025968" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG12514" /db_xref="UniProtKB/Swiss-Prot:P96722" /translation="MSKVFESKSLIEEAKSRKKQYETLEEQLNTLKKAFQGVADLGDN FKGNGADNIKDFFQGQAEIVDSWLTLVSAQIAFLNGISGDIKDQELNDSYVETSFLDH ELPNGDLKASEIVSAHKEEIDSILSGISDIIDLDMYTLDDYADKMGDAQKIRRDTITA VDKLDESLTTEYQNLESLDNAVLTKYSVLMQATSNGKSASPMYYDKKAFHSNEVYKSV IEVENQGTTYIDAKTQQAEARRLQEKAEEEANKPWYEKTWDGVCNFTGEVTGYYDYKR ATEGVDPVTGEKLSTAERVTAGAMAAAGFIPVVGWAGRAFKGGKAIYKTGKAAIAAEH ALDAYKTGKSLDILKMTEMGAYGLVASNGFSEAVTGRDMFGNKVSEEKRKQGALEAIT IIGGAGLAHYFDRLYQKNAPYVNKVSNESLISNIAKTTEEKQTRLQYLRNKHGVLSKE DLHHRINLRAEVLNELSRIKSSGLTKKQRGPAVAGVLDKKTGNYYFGINNIDGKPPKV LHPLIHDRIVNMPTELKEGYIKTSGAGSHAEVNALNEALLQRPDADLKDLMVYVVSAR KINKKMPEGVPMPRCPHCEYITQNTNYIPEALKYGK*" /label="rttN CDS" gene complement(3209914..3211722) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /label="rttN gene" CDS complement(3211741..3212001) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391501.1" /db_xref="EnsemblGenomes-Gn:BSU36200" /db_xref="EnsemblGenomes-Tr:CAB15637" /db_xref="InterPro:IPR020299" /db_xref="SubtiList:BG12513" /db_xref="UniProtKB/Swiss-Prot:P96721" /translation="MSEIKLKYDTVIKTLDSVKDALADVSIGAAGSNGKNSLDYTKKY HEREENIKTMLGDYKKAVQKNIEDTKDNVDSLKEQDEAIAVK*" /label="ywqI CDS" gene complement(3211741..3212001) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /label="ywqI gene" CDS complement(3212011..3212433) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15101989" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391502.1" /db_xref="EnsemblGenomes-Gn:BSU36210" /db_xref="EnsemblGenomes-Tr:CAB15638" /db_xref="InterPro:IPR020326" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG12512" /db_xref="UniProtKB/Swiss-Prot:P96720" /translation="MGYESMLADIKSSLNGKISDVEDKIEKLKKAKKDIDTLQEEAIT EIKEIVKPELGKHWTGTKADDFDKGREEAKSEASKIVNDKYNEYMASINGKIFDLEWD KAKYASELFIANGAADLLKKGEEFAEEVGNTISKLKWW*" /label="ywqH CDS" gene complement(3212011..3212433) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /label="ywqH gene" S_feature complement(3212434..3212516) /Source="Nicolas_S_feature" /locus_tag="new_3728120_3728202_c" /HighExp="T2.30H, T4.0H, T5.0H, T3.0H, T3.30H, T1.30H, T2.0H, S4, T-0.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1391" promotor_-10 complement(3212508..3212527) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3212516) /Source="Nicolas_upshifts" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3212540..3212547) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3212650..3212775) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514006.1" /translation="MTKSDMADQMKNINMNNKLSAERGRSTTSASFKCLYNYDIR*" /label="hypothetical protein CDS" gene complement(3212650..3212775) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /label="gene" S_feature complement(3212693..3212824) /Source="Nicolas_S_feature" /locus_tag="new_3728379_3728510_c" /HighExp="HiOs, BI, M9-tran, T-2.40H, MG 150, Sw, M9-exp, S1, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19133600000000001" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1392" downshifts complement(3212736) /Source="Nicolas_upshifts" /id="D1871" /incds=0 /nref=29 /ntot=208 /MaxReadThrough="3.03928" /MaxDrop="3.47153" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2835" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3212825..3213610) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391503.1" /db_xref="EnsemblGenomes-Gn:BSU36220" /db_xref="EnsemblGenomes-Tr:CAB15639" /db_xref="InterPro:IPR015315" /db_xref="InterPro:IPR035948" /db_xref="PDB:1PV5" /db_xref="SubtiList:BG12511" /db_xref="UniProtKB/Swiss-Prot:P96719" /translation="MNHLPEKMRPYRDLLEKSAKEYVKLNVRKGKTGRYDSKIAGDPY FPKHETYPTDENGQPMKLLAQINFSHIPQLDGYPSSGILQFYISVHDDVYGLNFDDRC EQKNFRVIYFENIVENDDELVSDFSFIGTGECDFPILSEAAVEPVKSSEWVLPTDFQF EQYTGMETMEFFGQFGEDEEDIYNELAENGFGHKIGGYASFTQHDPREYAYKEHTIML LQIDSDDDIDSMWGDVGIANFFITPEDLRKKDFSNVLYNWDCS*" /label="ywqG CDS" gene complement(3212825..3213610) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /label="ywqG gene" S_feature complement(3213611..3213726) /Source="Nicolas_S_feature" /locus_tag="new_3729297_3729412_c" /HighExp="HiOs, T-1.40H, T-2.40H, T-3.40H, M9-tran, MG 150, SMM, GM 150, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1393" promotor_-10 complement(3213719..3213738) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3213726) /Source="Nicolas_upshifts" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3213752..3213759) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3213802..3215124) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 15866923, 16415592" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 15866923, 16415592; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose dehydrogenase" /protein_id="NP_391504.1" /db_xref="EnsemblGenomes-Gn:BSU36230" /db_xref="EnsemblGenomes-Tr:CAB15640" /db_xref="GOA:P96718" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12510" /db_xref="UniProtKB/Swiss-Prot:P96718" /translation="MNITVIGTGYVGLVTGVSLSEIGHHVTCIDIDAHKIDEMRKGIS PIFEPGLEELMRKNTADGRLNFETSYEKGLAQADIIFIAVGTPQKSDGHANLEQITDA AKRIAKHVKRDTVVVTKSTVPVGTNDLINGLITEHLAEPVSISVASNPEFLREGSAIY DTFHGDRIVIGTADEKTANTLEELFRPFQIPIYQTDIRSAEMIKYASNAFLATKISFI NEISNICEKVGADIEAVAYGMGQDKRIGSQFLKAGIGYGGSCFPKDTNALVQIAGNVE HDFELLKSVIKVNNNQQAMLVDKALNRLGGVTGKTIALLGLSFKPNTDDMREAPSIVI ADRLAALDARIRAYDPIAVSHAKHVLPQAVEYKETIEEAVKGSDAVMILTDWADIKQF PLAAYQDLMETPLIFDGRNCYTLDEALAAGVEYYSVGRKAVVPSGAIQ*" /label="uglF CDS" gene complement(3213802..3215124) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /label="uglF gene" downshifts complement(3213814) /Source="Nicolas_upshifts" /id="D1872" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.29767" /MaxDrop="6.20721" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2836" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3215158) /Source="Nicolas_upshifts" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3215160..3215285) /Source="Nicolas_S_feature" /locus_tag="new_3730846_3730971_c" /HighExp="dia15, H2O2, Diami, dia5, LBGstat, Paraq, LBGexp, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13453899999999999" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1394" promotor_-10 complement(3215160..3215178) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3215194..3215199) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3215265..3215284) /Source="Nicolas_upshift_promotors" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3215285) /Source="Nicolas_upshifts" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3215319..3216083) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15866923, 16415592, 16549871, 21605684, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15866923, 16415592, 16549871, 21605684, 27148221; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein tyrosine-phosphatase" /protein_id="NP_391505.1" /db_xref="EnsemblGenomes-Gn:BSU36240" /db_xref="EnsemblGenomes-Tr:CAB15641" /db_xref="GOA:P96717" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR016667" /db_xref="PDB:3QY6" /db_xref="PDB:3QY7" /db_xref="SubtiList:BG12509" /db_xref="UniProtKB/Swiss-Prot:P96717" /translation="MIDIHCHILPAMDDGAGDSADSIEMARAAVRQGIRTIIATPHHN NGVYKNEPAAVREAADQLNKRLIKEDIPLHVLPGQEIRIYGEVEQDLAKRQLLSLNDT KYILIEFPFDHVPRYAEQLFYDLQLKGYIPVIAHPERNREIRENPSLLYHLVEKGAAS QITSGSLAGIFGKQLKAFSLRLVEANLIHFVASDAHNVKTRNFHTQEALYVLEKEFGS ELPYMLTENAELLLRNQTIFRQPPQPVKRRKLFGFF*" /label="ptpZ CDS" gene complement(3215319..3216083) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /label="ptpZ gene" downshifts complement(3216102) /Source="Nicolas_upshifts" /id="D1873" /incds=0 /nref=4 /ntot=152 /MaxReadThrough="3.17433" /MaxDrop="3.31415" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" CDS complement(3216136..3216849) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /EC_number="2.7.10.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maintenance protein tyrosine kinase involved in biofilm formation" /protein_id="NP_391506.1" /db_xref="EnsemblGenomes-Gn:BSU36250" /db_xref="EnsemblGenomes-Tr:CAB15642" /db_xref="GOA:P96716" /db_xref="InterPro:IPR005702" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12508" /db_xref="UniProtKB/Swiss-Prot:P96716" /translation="MALRKNRGSRMQRNVIAMTEPKSLNSEQYRTIRTNIEFASVDRQ MKSVMITSACPGEGKSTTAANLAVVFAQQGKKVLLIDADLRKPTVHTAFFLENTVGLT SVLLKKSSMEQAVQASNEKHLDVLTSGPIPPNPAELLSSKWMKELAYEACAAYDMVIF DTPPILAVADAQILGNVADGSVLVISSGKTEKEQAAKAKEALATCKSKLLGAIMNGKK LSKHSEYGYYGTKDNFMQK*" /label="ptkA CDS" gene complement(3216136..3216849) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /label="ptkA gene" downshifts complement(3216153) /Source="Nicolas_upshifts" /id="D1874" /incds=0 /nref=10 /ntot=157 /MaxReadThrough="4.4352" /MaxDrop="4.08842" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-381" /isTUend="FALSE" /label="downshifts" CDS complement(3216839..3217585) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 23939619, 24493247, 26283769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 23939619, 24493247, 26283769; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of PtkA protein tyrosine kinase activity; modulation of biofilm formation" /protein_id="NP_391507.1" /db_xref="EnsemblGenomes-Gn:BSU36260" /db_xref="EnsemblGenomes-Tr:CAB15643" /db_xref="GOA:P96715" /db_xref="InterPro:IPR003856" /db_xref="InterPro:IPR032807" /db_xref="SubtiList:BG12507" /db_xref="UniProtKB/Swiss-Prot:P96715" /translation="MGESTSLKEILSTLTKRILLIMIVTAAATAAGGLISFFALTPIY ENSTQILVNQSKNERKEVQFNDVQTNLQLINTYNVIIKSPAILDEVIKEMGLSMTSQE LNDKITVSSEQDSQVVNISVRDENAETAAHIANTIASVFQDKITSIMNVDNVSILSKA EVSEHPSPVSPKPLLNIAIAFAAGLAGSIGLAFLLEHLDNTIKSEEQLESLLDIPVLG TVSTIANEQKTAKTLQGFQSEKTGSGHFGA*" /label="tkmA CDS" gene complement(3216839..3217585) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /label="tkmA gene" promotor_-10 complement(3217617..3217636) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3217629) /Source="Nicolas_upshifts" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3217653..3217656) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3217819..3217962) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097792.1" /db_xref="EnsemblGenomes-Gn:BSU36269" /db_xref="EnsemblGenomes-Tr:CAX52703" /db_xref="UniProtKB/Swiss-Prot:C0H3S3" /translation="MSEKKLNQEEFLKILMHAHEIGEQSSEMTTKEMLENLISHIKNG YAT*" /label="ywzD CDS" gene complement(3217819..3217962) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /label="ywzD gene" downshifts complement(3217840) /Source="Nicolas_upshifts" /id="D1875" /incds=0 /nref=221 /ntot=264 /MaxReadThrough="2.76798" /MaxDrop="8.13076" /score="15.8630799" /energy="-9.3" /TU="U2839" /idTUdmin="U2841" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3217963..3218048) /Source="Nicolas_S_feature" /locus_tag="new_3733649_3733734_c" /HighExp="S6, S8, S7, MG-0.2, S5, M9-stat, MG-0.1, MG 25, T0.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD, SigK" /TUshortPSig="0.275, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1395" misc_feature complement(3218038..3218049) /Source="Nicolas_upshift_promotors" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3218048) /Source="Nicolas_upshifts" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3218050..3218280) /Source="Nicolas_S_feature" /locus_tag="new_3733736_3733966_c" /HighExp="S6, S8, S7, S5, BT, Cold, LBGstat, LPhT, Pyr, C30" /AntisenseName="ywqB" /AntisenseCor="3.4267833233812203E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1396" promotor_-35 3218087..3218091 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3218107..3218126 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3218116 /Source="Nicolas_upshifts" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="upshifts" CDS 3218166..3219776 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative replication initiation protein" /protein_id="NP_391508.2" /db_xref="EnsemblGenomes-Gn:BSU36270" /db_xref="EnsemblGenomes-Tr:CAB15644" /db_xref="GOA:P96714" /db_xref="InterPro:IPR007527" /db_xref="SubtiList:BG12506" /db_xref="UniProtKB/Swiss-Prot:P96714" /translation="MLQNMISKDDVLASAEQLKELLPYNEENVQLIKKALILYRQDSV YRLQAVSPTEVTAYVQDVVPVRVTLNLFVIVKSGCSCPSGRICRHMLAVFLYVYAMFE RVGTFTEYWLEREKLEESKELVRRQFQEKVLPNEESLSSWLAFFDSEFSLWQARTPEG SQNMQGLYYGYLSALKKHAPNKPELKSLYQIHSAIAVWLRMFTLIEAGKLNPEQDFYS LNPYVEQLMDTIYSSIDKLKTYALSFALDPFLDKTPDVIRHLLLKEEIFQYERIRVFG EIWSALLSRPKWVAREQEILKKEAGRRFSPELQFGRLHLEFLQKNDDVIFEEADQFPP EALPYTFQWLSEMTAKKDWKRLKTWYQQIEPIAMGYTKLDKPFKEIRDVIGELFLLLN AYVQQTNDQALFERFAAGCLPYTFTEYSHHLYEKKRYAEWIEIHSLVGFSINEMDKMM LKEIAASDPEALIPAYHREVAFFIDQKNRSSYKEAARYLKKLRTLYKKAKKQKVWERY IQLLSSHYKRLRALQEELQKGKLIDGES*" /label="ywqB CDS" gene 3218166..3219776 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /label="ywqB gene" promotor_-10 complement(3218268..3218286) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3218280) /Source="Nicolas_upshifts" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3218282..3218456) /Source="Nicolas_S_feature" /locus_tag="new_3733968_3734142_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, B60, C30" /AntisenseName="ywqB" /AntisenseCor="-0.10880748846525" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1397" promotor_-35 complement(3218300..3218307) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3218443..3218462) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3218456) /Source="Nicolas_upshifts" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3218476..3218484) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3219763..3222531 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9507009, 9614128, 11751638, 17913745, 19282450; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATPase involved in RNA remodelling DNA recombination and repair" /protein_id="NP_391509.1" /db_xref="EnsemblGenomes-Gn:BSU36280" /db_xref="EnsemblGenomes-Tr:CAB15645" /db_xref="GOA:P94593" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR022138" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12505" /db_xref="UniProtKB/Swiss-Prot:P94593" /translation="MASLKEILIHVEQMEDGSFTLSAFDENEQPLPYSHMKKHLFQWH ESSFYGTFLEDVSFIGTTAVLLSPWMTVELLGKNSFNSFSSVQLTEETEPLIEAASTI YEFIADGDFMPDYDAWTNGVFRWKDRDNILEGFTAEWFSAAVQDYIQYDDDLREKWEH IKEKSPAVTTFRGHFLDEEDFLEGIGWIDDQSPFTVGLRLNEPDFDGDEWKIEMFLRD KKSGAVEFFDGLKSLKKSWQAYSDKIAREQDRFHRTVPWLSFDSGTTLISEEEAWIFL SEASETLVDMGVEILLPSWWQIVRDSNMMLKAKVSSSPRGESFVGMNALLDFNWRFAT NGIELTEAEFNELVASNRRLVNIRGQWVKIDPQFIKQMKRLMEKAESEGLHMSDILAR ELMDQQDGGLEDSDLIDTSAFAGIQFDLSKQLRSLIRKLTAAENLPEHKVSPSFKGTL RPYQKYGMNWLLFLRESGFGACLADDMGLGKTIQMIAYFLHVKESGRQKTPHLIIAPT SVLGNWQRELQTFAPDLSVALHYGPRRPKGDDFAAHYENADVVLTSYGLSHADTEELS SVTWNTICLDEAQNIKNAHTKQSRAIRKLKGLHHIALSGTPMENRLTELWSIFDFMNK GYLGSLTGFHKRYVLPIEKDRDEKRIGQLQQLIRPFLLRRTKRDEEVALNLPEKLEEK EFIPLSAEQASLYEQLVKDTFDHMTSLTGMQRKALILSMLGRLKQICDHPALYLKEEQ TELLAGRSVKLEKLLELMTAIRAQNESCLIFTQYIQMGNMMKRLLEKTFGEPVQFLNG SLSKQERDTLVEKFQRKEYPTLILSLKAGGTGLNLTAANHVIHYDRWWNPAVENQATD RAYRIGQERFVHVHKMITTGTIEEKIDVMLESKQTLNDQIIQSENWITELSTQELEEL FTLSATAQ*" /label="hepA CDS" gene 3219763..3222531 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /label="hepA gene" downshifts complement(3222580) /Source="Nicolas_upshifts" /id="D1876" /incds=0 /nref=9 /ntot=202 /MaxReadThrough="1.80101" /MaxDrop="4.14573" /score="30.708119" /energy="-14.4" /TU="U2843" /idTUdmin="U2844" /TUdmin=12 /isTUend="TRUE" /label="downshifts" CDS complement(3222657..3223514) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25848029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase of unidentified specificity (possibly promiscuous)" /protein_id="NP_391510.1" /db_xref="EnsemblGenomes-Gn:BSU36290" /db_xref="EnsemblGenomes-Tr:CAB15646" /db_xref="GOA:P94592" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:1NRW" /db_xref="SubtiList:BG12504" /db_xref="UniProtKB/Swiss-Prot:P94592" /translation="MKLIAIDLDGTLLNSKHQVSLENENALRQAQRDGIEVVVSTGRA HFDVMSIFEPLGIKTWVISANGAVIHDPEGRLYHHETIDKKRAYDILSWLESENYYYE VFTGSAIYTPQNGRELLDVELDRFRSANPEADLSVLKQAAEVQYSQSGFAYINSFQEL FEADEPIDFYNILGFSFFKEKLEAGWKRYEHAEDLTLVSSAEHNFELSSRKASKGQAL KRLAKQLNIPLEETAAVGDSLNDKSMLEAAGKGVAMGNAREDIKSIADAVTLTNDEHG VAHMMKHLL*" /label="ywpJ CDS" gene complement(3222657..3223514) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /label="ywpJ gene" CDS complement(3223520..3224296) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11491085" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11491085; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (glucose repression ofcatabolic operons)" /protein_id="NP_391511.1" /db_xref="EnsemblGenomes-Gn:BSU36300" /db_xref="EnsemblGenomes-Tr:CAB15647" /db_xref="GOA:P94591" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12503" /db_xref="UniProtKB/Swiss-Prot:P94591" /translation="MYQEERLVAILDFLKQHNRITTEQICTLLQVSRDTARRDLVKLE EQNAIIRTRGGAILPTVHQKIQSYSGRLKTVSEEKNKIGRLAASLIHDGDRVILDAST TVQACAKHLNAVDCTVITNSINLADVLSDKEGIEIYLLGGKLEKEHRFLYGSSVIEKL SSYHVDKALIGVVGISEHGITIAHEEDGMVKRKMIQQAKQVIALADHSKLGSTSFYQY AELNEIDLLITDRLPNQAFCDLLDRNGVELLVTEQDEGKD*" /label="glcR CDS" gene complement(3223520..3224296) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /label="glcR gene" promotor_-10 complement(3224322..3224341) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3224344) /Source="Nicolas_upshifts" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3224346..3224418) /Source="Nicolas_S_feature" /locus_tag="new_3740032_3740104_c" /HighExp="C30, GM 150, T-4.40H, G/S, C90, S2, T-5.40H, T-3.40H, T-2.40H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1398" promotor_-35 complement(3224356..3224363) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3224420..3224519) /Source="Nicolas_S_feature" /locus_tag="new_3740106_3740205_c" /HighExp="HiOs, S2, T-3.40H, T0.30H, C90, G/S, T1.0H, T0.0H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1399" downshifts complement(3224463) /Source="Nicolas_upshifts" /id="D1877" /incds=0 /nref=221 /ntot=258 /MaxReadThrough="3.81096" /MaxDrop="7.17295" /score="-7.00620083" /energy="-7.5" /TU="U2844" /idTUdmin="U2846" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(3224520..3224861) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762004, 16009133, 16549871, 17630974, 25138221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762004, 16009133, 16549871, 17630974, 25138221; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391512.2" /db_xref="EnsemblGenomes-Gn:BSU36310" /db_xref="EnsemblGenomes-Tr:CAB15648" /db_xref="GOA:C0SPB6" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="PDB:3VDY" /db_xref="SubtiList:BG12502" /db_xref="UniProtKB/Swiss-Prot:C0SPB6" /translation="MFNQVMLVGRLTKDPDLRYTSAGAAVAHVTLAVNRSFKNASGEI EADYVNCTLWRKTAENTALYCQKGSLVGVSGRIQTRSYENEEGVNVYVTEVLADTVRF MDPKPREKAAD*" /label="ssbB CDS" gene complement(3224520..3224861) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /label="ssbB gene" promotor_-10 complement(3224883..3224902) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3224902) /Source="Nicolas_upshifts" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3224916..3224923) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3224938..3225321) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="interaction partner of DynA" /protein_id="NP_391513.1" /db_xref="EnsemblGenomes-Gn:BSU36320" /db_xref="EnsemblGenomes-Tr:CAB15649" /db_xref="SubtiList:BG12501" /db_xref="UniProtKB/Swiss-Prot:P94589" /translation="MNQFRLKEIYIDGVPSESHLIQKEVTYMLSRKEVFEVHLNKKGR ISFLYETQDGMEQYKIKLSMPEKKLSFQWFAWDGSSYVRMNTQNWLTKQIFFRFLKST YFFKGKKQKMFLAEGKMKTKDKNRG*" /label="ywpG CDS" gene complement(3224938..3225321) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /label="ywpG gene" promotor_-10 complement(3225343..3225362) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-10" misc_feature 3225350..3225369 /Source="Nicolas_upshift_promotors" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3225354 /Source="Nicolas_upshifts" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3225363) /Source="Nicolas_upshifts" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="upshifts" promotor_-35 complement(3225377..3225384) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-35" misc_feature 3225444..3225463 /Source="Nicolas_upshift_promotors" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3225447 /Source="Nicolas_upshifts" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3225496) /Source="Nicolas_upshifts" /id="D1878" /incds=0 /nref=2 /ntot=169 /MaxReadThrough="0.85282" /MaxDrop="4.02798" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2846" /TUdmin="-1034" /isTUend="FALSE" /label="downshifts" CDS 3225496..3225906 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25663006" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391514.1" /db_xref="EnsemblGenomes-Gn:BSU36330" /db_xref="EnsemblGenomes-Tr:CAB15650" /db_xref="InterPro:IPR025573" /db_xref="SubtiList:BG12500" /db_xref="UniProtKB/Swiss-Prot:P94588" /translation="MKTFKLVDLNVERVDKEEQSIEQFPLIDGLIINKEDGENHWLIE ALVQKEHLSFFEQLQNSQSEAKVFVTITKKSNRPAQLTAAVKNIVKLEESIQVLLYGQ MVTRKQQGTETILESLVKEGYTGTKLIEAFKQKL*" /label="ywpF CDS" gene 3225496..3225906 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /label="ywpF gene" S_feature 3225907..3225990 /Source="Nicolas_S_feature" /locus_tag="new_3741593_3741676" /HighExp="BC, LBGtran, T3.30H, Etha, T2.0H, Lbtran, M9-stat, T3.0H, dia5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1400" downshifts 3225948 /Source="Nicolas_upshifts" /id="D1879" /incds=0 /nref=214 /ntot=260 /MaxReadThrough="1.83981" /MaxDrop="6.19197" /score="18.4023831" /energy="-14" /TU="NA" /idTUdmin="U2847" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3226046..3226354) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 21800427, 21906378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sortase" /protein_id="NP_391515.1" /db_xref="EnsemblGenomes-Gn:BSU36340" /db_xref="EnsemblGenomes-Tr:CAB15651" /db_xref="GOA:P94587" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG12499" /db_xref="UniProtKB/Swiss-Prot:P94587" /translation="MRRDQKMGEGNYPLAGHHLKQKNLLFGPLENIKTGAQIVITDFK KDYIYSVTSKDIISEMDADVVEETNKKEITLITCDKAVKTEGRLVVKGELVDSFGHTN *" /label="ywpE CDS" gene complement(3226046..3226354) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /label="ywpE gene" downshifts complement(3226047) /Source="Nicolas_upshifts" /id="D1880" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="0.11027" /MaxDrop="2.8132" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2849" /TUdmin=1540 /isTUend="FALSE" /label="downshifts" CDS 3226698..3227534 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16740923; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative two-component sensor histidine kinase" /protein_id="NP_391516.1" /db_xref="EnsemblGenomes-Gn:BSU36350" /db_xref="EnsemblGenomes-Tr:CAB15652" /db_xref="GOA:P94586" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12498" /db_xref="UniProtKB/Swiss-Prot:P94586" /translation="MKIRERFSMVDLPVLIITAAIIGHDKYKAFHAGANDILQKPYHY SEFMARIQNLIMMKHTANQATRMEMAFLQSQIKPHFLYNVLNTIISLTHLDIEKAREV TEEFTNYLRMSFDFQNTSAISSFRHELSIINSYLSIEKTRFSNRLEVLFDIDEDIDFI LPPLMIQPLVENAVLHGVSKKRGGGWIKLTAKKQSKNEYHIKVEDNGPGITPEKQIDL LSTDFDRSVGLKNINQRLKHFCGSELMISSTPDAGTSVSMLIHLAETTGSPKELKDTE RT*" /label="ywpD CDS" gene 3226698..3227534 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /label="ywpD gene" promotor_-35 3226914..3226921 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3226936..3226955 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3226939 /Source="Nicolas_upshifts" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3227533 /Source="Nicolas_upshifts" /id="D1881" /incds=0 /nref=13 /ntot=132 /MaxReadThrough="0.11837" /MaxDrop="3.37937" /score="9.16906941" /energy="-8.6" /TU="NA" /idTUdmin="U2848" /TUdmin=154 /isTUend="FALSE" /label="downshifts" CDS complement(3227581..3227973) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /function="16.1: Circulate" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12948773, 15063854, 15165739, 16897034, 22685134, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12948773, 15063854, 15165739, 16897034, 22685134, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="large conductance mechanosensitive channel protein" /protein_id="NP_391517.1" /db_xref="EnsemblGenomes-Gn:BSU36360" /db_xref="EnsemblGenomes-Tr:CAB15653" /db_xref="GOA:P94585" /db_xref="InterPro:IPR001185" /db_xref="InterPro:IPR019823" /db_xref="InterPro:IPR036019" /db_xref="SubtiList:BG12497" /db_xref="UniProtKB/Swiss-Prot:P94585" /translation="MWNEFKAFAMRGNIVDLAIGVVIGGAFGKIVTSLVNDIIMPLVG LLLGGLDFSGLSFTFGDAVVKYGSFIQTIVNFLIISFSIFIVIRTLNGLRRKKEAEEE AAEEAVDAQEELLKEIRDLLKQQAKSPE*" /label="mscL CDS" gene complement(3227581..3227973) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /label="mscL gene" downshifts complement(3227587) /Source="Nicolas_upshifts" /id="D1882" /incds=0 /nref=216 /ntot=255 /MaxReadThrough="2.23487" /MaxDrop="6.5103" /score="28.9904077" /energy="-11.4" /TU="NA" /idTUdmin="U2849" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3228046..3228471) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /EC_number="4.2.1.59" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8910376, 12682299, 15194690, 15371447, 18093984, 22580319, 23322253, 27874013; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacyl-[acyl carrier protein] dehydratase" /protein_id="NP_391518.2" /db_xref="EnsemblGenomes-Gn:BSU36370" /db_xref="EnsemblGenomes-Tr:CAB15654" /db_xref="GOA:P94584" /db_xref="InterPro:IPR010084" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12496" /db_xref="UniProtKB/Swiss-Prot:P94584" /translation="MLDTQQIKEIIPHRYPFLLVDRITEVEEGKRAKGYKNVTANEEF FNGHFPQYPVMPGVLIVEALAQVGAVAMLIKEENRGRLAFFAGIDNCRFKKQVKPGDQ LHLEVEIIRARGTIGRGKGVATVDGEVVCEVELTFALGE*" /label="fabZ CDS" gene complement(3228046..3228471) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /label="fabZ gene" promotor_-10 complement(3228532..3228551) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3228548) /Source="Nicolas_upshifts" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3228550..3228634) /Source="Nicolas_S_feature" /locus_tag="new_3744236_3744320_c" /HighExp="Diami, dia5, Cold, dia15, H2O2, C30, Etha, Oxctl, Paraq, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigD, SigA" /TUlongPSig="0.999, 0.837" /label="S1401" promotor_-35 complement(3228566..3228573) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3228613 /Source="Nicolas_upshifts" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3228616..3228635 /Source="Nicolas_upshift_promotors" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3228626..3228645) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-10" upshifts complement(3228634) /Source="Nicolas_upshifts" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="upshifts" S_feature complement(3228636..3229720) /Source="Nicolas_S_feature" /locus_tag="new_3744322_3745406_c" /HighExp="Cold, C30, Lbstat, Glucon, Glu, Paraq, Pyr, H2O2, Fru, C90" /AntisenseName="rapD" /AntisenseCor="5.8390464430913601E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.837" /label="S1402" promotor_-35 complement(3228659..3228664) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-35" CDS 3228663..3229727 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391519.1" /db_xref="EnsemblGenomes-Gn:BSU36380" /db_xref="EnsemblGenomes-Tr:CAB15655" /db_xref="GOA:P94583" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11967" /db_xref="UniProtKB/Swiss-Prot:P94583" /translation="MISKFIEKRMLNMLDEWYSAMSKRKMNHVCTLKEKIDQHLPKIK KNTKLWMRYQLFQARHQLLFENQNGLDSLFDGLYGLEDKMDDELKYYLYFFSGLYEMV KTAPKHAVHHFKKAEQYLAAIHNTFEAADLYYQTAGAYYLMKSPPLSVQYVKKALHIY LHQFGYIKKVITCKLLLAVNYIDQERYEKAEQLFKEIIKKTQQLHDENLLCHAYYNLG FLKATEKKDQEALLYFRKVLKNQEFEMNSPVSYLHCVYESVRALFKTGNITEAKAVLQ KGKELSEKVDIQTIYLKLKTLEALYTSAEDPYEQLLEYVLELEKIEAWVDLEVLLEDI TEYYKKKDDFEKAAFFIMRG*" /label="rapD CDS" gene 3228663..3229727 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /label="rapD gene" S_feature 3229728..3230612 /Source="Nicolas_S_feature" /locus_tag="new_3745414_3746298" /HighExp="M9-stat, T4.0H, T2.0H, T3.30H, T2.30H, T3.0H, T1.30H, T5.0H, T1.0H, T0.30H" /AntisenseName="flhP" /AntisenseCor="-0.32116112580252298" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1403" CDS complement(3229750..3230559) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar hook-basal body accessory protein" /protein_id="NP_391520.2" /db_xref="EnsemblGenomes-Gn:BSU36390" /db_xref="EnsemblGenomes-Tr:CAB15656" /db_xref="GOA:P39753" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="InterPro:IPR020013" /db_xref="SubtiList:BG10918" /db_xref="UniProtKB/Swiss-Prot:P39753" /translation="MLRSMLTASTTLNQLQQQIDTISSNLSNSNTTGYKAKDTNFSEL VRQQFDQVDEKNEEVAKARKTPPGLRLGVGAMMSSRLVSDQGSIQKTDRDLDIAFTSP YQYLQVNVNGNRQYTRDGALYVTPSAANANQLQLVTGNGYPVLDENGNTVNIDSSMKN ITINKNGTLTASDGNAVQRFNLGVVQVNNPQELKSEGNNLFSIDNAAAFEELNGANRQ NIGMQQGSLEMSNVDISEQMTDLITSQRSYQLNSRTITMGDQMLGLINSVR*" /label="flhP CDS" gene complement(3229750..3230559) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /label="flhP gene" downshifts complement(3229765) /Source="Nicolas_upshifts" /id="D1883" /incds=0 /nref=174 /ntot=256 /MaxReadThrough="4.65461" /MaxDrop="5.56507" /score="8.59904552" /energy="-7.4" /TU="U2853" /idTUdmin="U2854" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3230593..3231405) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1905667, 16621824, 22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905667, 16621824, 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal-body accessory rod protein" /protein_id="NP_391521.1" /db_xref="EnsemblGenomes-Gn:BSU36400" /db_xref="EnsemblGenomes-Tr:CAB15657" /db_xref="GOA:P39752" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10917" /db_xref="UniProtKB/Swiss-Prot:P39752" /translation="MLKGLYTATSAMIAQQRRTEMLSNNIANANTSGYKADQGSMRAF PEMLLSRIESKSPAGTSRTEIGSVNTGVYMQELKPLFTQGSLKSTDQPTDIALIENQV PMSAETNEKAALFYPVQTADGIRYSKSSTFSLNENNQLTINGRPILSTDRQPITVDNE NFTVSENGTVTTNGRTAGQIDVRMAEDVRNLKRDGNDLYSTADGNDLPSAAGNNQVAY SLKQGVSELSNVDVTSAYTEMTEAYRSFEANQKVIQAYDKSMDKAANEIGKI*" /label="flhO CDS" gene complement(3230593..3231405) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /label="flhO gene" S_feature complement(3231406..3231485) /Source="Nicolas_S_feature" /locus_tag="new_3747092_3747171_c" /HighExp="C90, Lbtran, Cold, GM-0.2, GM 15, GM 10, C30, GM 90, GM-0.1, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.999, 0.837" /TUlongSig="NA" /TUlongPSig="NA" /label="S1404" promotor_-35 3231436..3231443 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3231457..3231476 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3231466 /Source="Nicolas_upshifts" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3231479..3231497) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-10" upshifts complement(3231485) /Source="Nicolas_upshifts" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="upshifts" promotor_-35 complement(3231511..3231518) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-35" CDS complement(3231568..3232569) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="MreB-like morphogen" /protein_id="NP_391522.2" /db_xref="EnsemblGenomes-Gn:BSU36410" /db_xref="EnsemblGenomes-Tr:CAB15658" /db_xref="GOA:P39751" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10916" /db_xref="UniProtKB/Swiss-Prot:P39751" /translation="MFARDIGIDLGTANVLIHVKGKGIVLNEPSVVALDKNSGKVLAV GEEARRMVGRTPGNIVAIRPLKDGVIADFEVTEAMLKHFINKLNVKGLFSKPRMLICC PTNITSVEQKAIKEAAEKSGGKHVYLEEEPKVAAIGAGMEIFQPSGNMVVDIGGGTTD IAVISMGDIVTSSSIKMAGDKFDMEILNYIKREYKLLIGERTAEDIKIKVATVFPDAR HEEISIRGRDMVSGLPRTITVNSKEVEEALRESVAVIVQAAKQVLERTPPELSADIID RGVIITGGGALLNGLDQLLAEELKVPVLVAENPMDCVAIGTGVMLDNMDKLPKRKLS* " /label="mbl CDS" gene complement(3231568..3232569) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /label="mbl gene" downshifts complement(3231574) /Source="Nicolas_upshifts" /id="D1884" /incds=0 /nref=108 /ntot=240 /MaxReadThrough="5.6154" /MaxDrop="4.18076" /score="20.122637" /energy="-11.2" /TU="U2854" /idTUdmin="U2855" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" misc_feature complement(3232624..3232643) /Source="Nicolas_upshift_promotors" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3232648) /Source="Nicolas_upshifts" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="upshifts" S_feature complement(3232650..3232734) /Source="Nicolas_S_feature" /locus_tag="new_3748336_3748420_c" /HighExp="S5, S6, S4, S7, S8, S3, B36, T5.0H, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1405" CDS complement(3232735..3233016) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023218, 9324264, 15598884, 22720735, 24584501" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023218, 9324264, 15598884, 22720735, 24584501; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (stage III sporulation)" /protein_id="NP_391523.1" /db_xref="EnsemblGenomes-Gn:BSU36420" /db_xref="EnsemblGenomes-Tr:CAB15659" /db_xref="GOA:P15281" /db_xref="InterPro:IPR014208" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="PDB:2L0K" /db_xref="SubtiList:BG10408" /db_xref="UniProtKB/Swiss-Prot:P15281" /translation="MHDYIKERTIKIGKYIVETKKTVRVIAKEFGVSKSTVHKDLTER LPEINPDLANEVKEILDYHKSIRHLRGGEATKLKYKKDEILEGEPVQQS*" /label="spoIIID CDS" gene complement(3232735..3233016) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /label="spoIIID gene" CDS complement(3233031..3233141) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9023218; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative factor required for translation of spoIIID" /protein_id="NP_391524.1" /db_xref="EnsemblGenomes-Gn:BSU36430" /db_xref="EnsemblGenomes-Tr:CAB15660" /db_xref="SubtiList:BG11984" /db_xref="UniProtKB/Swiss-Prot:O32276" /translation="MGIFHKLTFKTIQRRSGIMNDSLQNTDLISHFSHPF*" /label="usd CDS" gene complement(3233031..3233141) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /label="usd gene" promotor_-10 complement(3233172..3233190) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3233194) /Source="Nicolas_upshifts" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3233206..3233211) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3233287..3233293 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3233307..3233326 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3233323 /Source="Nicolas_upshifts" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="upshifts" CDS 3233366..3233779 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391525.1" /db_xref="EnsemblGenomes-Gn:BSU36440" /db_xref="EnsemblGenomes-Tr:CAB15661" /db_xref="GOA:P94578" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12495" /db_xref="UniProtKB/Swiss-Prot:P94578" /translation="MSYVNRHLIHQINQSARLIAKKANEQLEPFGLYSSQWSVLYCLR TIGPMTQKEIWSYLNVEAPTVTRTIKRLEENGWVQRRQGEDKREKLVVLTKEAEKKYE EINVKMLKFEEELLADFRDEDKEAFSHLFRMFLQQ*" /label="ywoH CDS" gene 3233366..3233779 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /label="ywoH gene" CDS 3233801..3234991 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391526.1" /db_xref="EnsemblGenomes-Gn:BSU36450" /db_xref="EnsemblGenomes-Tr:CAB15662" /db_xref="GOA:P94577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12494" /db_xref="UniProtKB/Swiss-Prot:P94577" /translation="MKKADAIWTKDFIMVLLVNLFVFVFFYTFLTVLPIYTLQELGGT ESQGGLLISLFLLSAIITRPFSGAIVERFGKKRMAIVSMALFALSSFLYMPIHNFSLL LGLRFFQGIWFSILTTVTGAIAADIIPAKRRGEGLGYFAMSMNLAMAIGPFLGLNLMR VVSFPVFFTAFALFMVAGLLVSFLIKVPQSKDSGTTVFRFAFSDMFEKGALKIATVGL FISFCYSTVTSYLSVFAKSVDLSDISGYFFVCFAVTMMIARPFTGKLFDKVGPGIVIY PSILIFSVGLCMLSFTHSGLMLLLSGAVIGLGYGSIVPCMQTLAIQKSPAHRSGFATA TFFTFFDSGIAVGSYVFGLFVASAGFSAIYLTAGLFVLIALLLYTWSQKKPAEAEGKV SIAE*" /label="ywoG CDS" gene 3233801..3234991 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /label="ywoG gene" CDS complement(3235082..3236488) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15266115, 16607952, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pectin lyase" /protein_id="NP_391527.1" /db_xref="EnsemblGenomes-Gn:BSU36460" /db_xref="EnsemblGenomes-Tr:CAB15663" /db_xref="GOA:P94576" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12493" /db_xref="UniProtKB/Swiss-Prot:P94576" /translation="MRKWYFILLAGVLTSVILAFVYDKTKANEEGSGDYLYVSPNGSD QNEGTKEKPFRTLAHASEKAAAGTTVMIREGTYHETLDVKHSGTDGKPITFRNYENEN VVISGESVANAEYETPLIRIHDKHDIAISGLTIQDLSVSSEEATAIGIYVSGSSSHIA IKDNHIRGIKTTADEGNAHGIAVYGTGSMKDIRIEDNTVEKLTLGASEAVVLNGNIDG FTVAGNVVRNNNNIGIDLIGYEGTADKNDYVRNGVVENNTVYQNSTYGNPAYGDEYSA GGIYVDGGHDIEIKNNTVYDNDIGIEATSEHKGKYANAIQITDNKVYNNAYTGISIGG YDKKRGGTSNSLIARNIMYRNDTKGLYGGQLLLQYDTKNNTIEKNILTAGDSRLFIGN DFTENEGNTVNHNVYHKEADQDGIWMWKKKEYDSFSSYRKATKNDQQSIYADPMFRDE ASYDFSLDPDSPARPVIE*" /label="ywoF CDS" gene complement(3235082..3236488) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /label="ywoF gene" downshifts complement(3235379) /Source="Nicolas_upshifts" /id="D1885" /incds=1 /nref=1 /ntot=78 /MaxReadThrough="5.28695" /MaxDrop="2.1962" /score="4.73902293" /energy="-22.3" /TU="U2857" /idTUdmin="U2857" /TUdmin="-924" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3236521..3236540) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3236539) /Source="Nicolas_upshifts" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3236555..3236558) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3236594..3238066) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 15849754, 16850406, 26967546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 15849754, 16850406, 26967546; Product type t : transporter" /codon_start=1 /transl_table=11 /product="allantoin permease" /protein_id="NP_391528.1" /db_xref="EnsemblGenomes-Gn:BSU36470" /db_xref="EnsemblGenomes-Tr:CAB15664" /db_xref="GOA:P94575" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR012681" /db_xref="SubtiList:BG12492" /db_xref="UniProtKB/Swiss-Prot:P94575" /translation="MKLKESQQQSNRLSNEDLVPLGQEKRTWKAMNFASIWMGCIHNI PTYATVGGLIAIGLSPWQVLAIIITASLILFGALALNGHAGTKYGLPFPVIIRASYGI YGANIPALLRAFTAIMWLGIQTFAGSTALNILLLNMWPGWGEIGGEWNILGIHLSGLL SFVFFWAIHLLVLHHGMESIKRFEVWAGPLVYLVFGGMVWWAVDIAGGLGPIYSQPGK FHTFSETFWPFAAGVTGIIGIWATLILNIPDFTRFAETQKEQIKGQFYGLPGTFALFA FASITVTSGSQVAFGEPIWDVVDILARFDNPYVIVLSVITLCIATISVNVAANIVSPA YDIANALPKYINFKRGSFITALLALFTVPWKLMESATSVYAFLGLIGGMLGPVAGVMM ADYFIIRKRELSVDDLYSETGRYVYWKGYNYRAFAATMLGALISLIGMYVPVLKSLYD ISWFVGVLISFLFYIVLMRVHPPASLAIETVEHAQVRQAE*" /label="pucI CDS" gene complement(3236594..3238066) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /label="pucI gene" CDS complement(3238247..3239605) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391529.1" /db_xref="EnsemblGenomes-Gn:BSU36480" /db_xref="EnsemblGenomes-Tr:CAB15665" /db_xref="GOA:P94574" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12491" /db_xref="UniProtKB/Swiss-Prot:P94574" /translation="MLSKKSRAVFLTAVASGTMLNPLNSSMISLALHSIQHEFHLSFT TVSWLISSFYLASAVAQPVTGKLGDLIGRKRLFLFGLILVAVSAIGAPFAPTFMTLLV MRLFQSVGSSAIYPSGVGLIRNHIHERQASALAVLSIFASAMTALGPTAGGFLIVWGG WPAIFIVNLPFIILSFLLGLYMFPKDQKKGAGIKTIIRQLDILGIVLFAGGIIFLLSF LLSFSTSPHAVEGVLGLLLLCAFVWRELKTDKPFIDVRLFKTQRNLSAVYVQFILLNV FFYCLFFGLPSYFQDEMHLSVQTSGLFMLFMSGMSIVVSPLTGKWIDRSGVVKPIFAG ALLMTAGAVLLTIFFINVQTIGKGLILSLLGIGYGLGNVALQAAMLETSPSNMVGTTS GLFQTCRYLGSILSSVILGILFGKEITAAHFDMMGIIMIIAGGASLLMAVRFAALMKT AS*" /label="ywoD CDS" gene complement(3238247..3239605) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /label="ywoD gene" downshifts complement(3238261) /Source="Nicolas_upshifts" /id="D1886" /incds=0 /nref=58 /ntot=198 /MaxReadThrough="1.44148" /MaxDrop="4.13092" /score="20.2036192" /energy="-12.8" /TU="NA" /idTUdmin="U2858" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3239605..3240174) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme of isochorismatase family" /protein_id="NP_391530.2" /db_xref="EnsemblGenomes-Gn:BSU36490" /db_xref="EnsemblGenomes-Tr:CAB15666" /db_xref="GOA:P94573" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12490" /db_xref="UniProtKB/Swiss-Prot:P94573" /translation="MMNTLNIDFQKTALVIIDLQKGIVPIDQSGQVVPNAKKLVDEFR KHNGFISFVNVAFHDGADALKPQTDEPAQGGSGEMPADWAEFVPEIGVQDGDYTVTKR QWGAFFGTDLDLQLRRRGIDTIVLCGIATNIGVESTAREAFQLGYQQIFITDAMSTFS DEEHEATLRFIFPRIGKSRTTEEFLEQVK*" /label="ywoC CDS" gene complement(3239605..3240174) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /label="ywoC gene" promotor_-10 complement(3240193..3240204) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3240211) /Source="Nicolas_upshifts" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3240218..3240224) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3240281..3240448) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CCQ48605.1" /translation="MSYPALDGPPQIHGHFQAGTDRQQAGDEAMTPFMITVLAGLFVC TTCYYYIKEKS*" /label="hypothetical protein CDS" gene complement(3240281..3240448) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /pseudo /label="gene" CDS complement(3240358..3240822) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21856850; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391531.1" /db_xref="EnsemblGenomes-Gn:BSU36500" /db_xref="EnsemblGenomes-Tr:CAB15667" /db_xref="GOA:P94572" /db_xref="InterPro:IPR020218" /db_xref="SubtiList:BG12489" /db_xref="UniProtKB/Swiss-Prot:P94572" /translation="MMNKGGRLRKAVRKSIPATFRLFLAFNFFVYGLAKVVIGQFGEV TPEIEAAAGKGFTIAWTFFGYSHVYELFIGFGEILAAVLLLIPRTAALGAVIFMPIIV NIVLINYCFDIGVQDLSTILMVMCLILLWMDRRKFMGIFRQEPIDSRQVMKR*" /label="ywoB CDS" gene complement(3240358..3240822) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /label="ywoB gene" promotor_-10 complement(3240852..3240871) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3240857) /Source="Nicolas_upshifts" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3240885..3240892) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3241023..3241026 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3241041..3241060 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3241045 /Source="Nicolas_upshifts" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="upshifts" CDS 3241104..3242318 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 15849754, 16850406, 17001076, 21435182" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 15849754, 16850406, 17001076, 21435182; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ammonium transporter" /protein_id="NP_391532.1" /db_xref="EnsemblGenomes-Gn:BSU36510" /db_xref="EnsemblGenomes-Tr:CAB15668" /db_xref="GOA:Q07429" /db_xref="InterPro:IPR001905" /db_xref="InterPro:IPR018047" /db_xref="InterPro:IPR024041" /db_xref="InterPro:IPR029020" /db_xref="SubtiList:BG10869" /db_xref="UniProtKB/Swiss-Prot:Q07429" /translation="MQMGDTVFMFFCALLVWLMTPGLALFYGGMVKSKNVLSTAMHSF SSIAIVSIVWVLFGYTLAFAPGNSIIGGLEWAGLKGVGFDPGDYSDTIPHSLFMMFQM TFAVLTTAIISGAFAERMRFGAFLLFSVLWASLVYTPVAHWVWGGGWIGQLGALDFAG GNVVHISSGVAGLVLAIVLGKRKDGTASSPHNLIYTFLGGALIWFGWFGFNVGSALTL DGVAMYAFINTNTAAAAGIAGWILVEWIINKKPTMLGAVSGAIAGLVAITPAAGFVTP FASIIIGIIGGAVCFWGVFSLKKKFGYDDALDAFGLHGIGGTWGGIATGLFATTSVNS AGADGLFYGDASLIWKQIVAIAATYVFVFIVTFVIIKIVSLFLPLRATEEEESLGLDL TMHGEKAYQDSM*" /label="amtB CDS" gene 3241104..3242318 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /label="amtB gene" promotor_-10 complement(3241934..3241952) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3241935) /Source="Nicolas_upshifts" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3241966..3241973) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3242184..3242190 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3242204..3242223 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3242206 /Source="Nicolas_upshifts" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="upshifts" CDS 3242330..3242680 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 17001076, 21435182, 23461034, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen-regulated PII-like regulator protein" /protein_id="NP_391533.1" /db_xref="EnsemblGenomes-Gn:BSU36520" /db_xref="EnsemblGenomes-Tr:CAB15669" /db_xref="GOA:Q07428" /db_xref="InterPro:IPR002187" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017918" /db_xref="PDB:4R25" /db_xref="PDB:4RX6" /db_xref="SubtiList:BG10870" /db_xref="UniProtKB/Swiss-Prot:Q07428" /translation="MSGQMFKVEIVTRPANFEKLKQELGKIGVTSLTFSNVHGCGLQK AHTELYRGVKIESNVYERLKIEIVVSKVPVDQVTETAKRVLKTGSPGDGKIFVYEISN TINIRTGEEGPEAL*" /label="glnK CDS" gene 3242330..3242680 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /label="glnK gene" downshifts 3242673 /Source="Nicolas_upshifts" /id="D1887" /incds=0 /nref=179 /ntot=251 /MaxReadThrough="2.13701" /MaxDrop="8.63831" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2860" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3242732..3242740 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3242754..3242762 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3242761 /Source="Nicolas_upshifts" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3242803..3242812 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3242825..3242840 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3242829 /Source="Nicolas_upshifts" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="upshifts" CDS 3242861..3243442 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /EC_number="3.6.1.27" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate phosphatase (bacitracin resistance)" /protein_id="NP_391534.1" /db_xref="EnsemblGenomes-Gn:BSU36530" /db_xref="EnsemblGenomes-Tr:CAB15670" /db_xref="GOA:P94571" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR033879" /db_xref="InterPro:IPR036938" /db_xref="SubtiList:BG12488" /db_xref="UniProtKB/Swiss-Prot:P94571" /translation="MNYEIFKAIHGLSHHNSVLDSIMVFITEYAIVAYALILLAIWLF GNTQSRKHVLYAGITGIAGLVINYLITLVYFEPRPFVAHTVHTLIPHAADASFPSDHT TGALAISIAMLFRNRKIGWPLVIFGLLTGFSRIWVGHHYPVDVLGSLVVAIIIGFLFF RFSDLLRPFVDLVVRIYEAIINKLTKKPTDQNF*" /label="bcrC CDS" gene 3242861..3243442 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /label="bcrC gene" promotor_-10 complement(3242959..3242978) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3242969) /Source="Nicolas_upshifts" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3242992..3243000) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3243423 /Source="Nicolas_upshifts" /id="D1888" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.1929" /MaxDrop="6.53316" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2863" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(3243483..3243905) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14762009, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391535.1" /db_xref="EnsemblGenomes-Gn:BSU36540" /db_xref="EnsemblGenomes-Tr:CAB15671" /db_xref="GOA:P71045" /db_xref="InterPro:IPR006976" /db_xref="SubtiList:BG12487" /db_xref="UniProtKB/Swiss-Prot:P71045" /translation="MNRLLLAGWIFFILLSVCTESFSGMVVSQTVAFHFQPHPDLSQF LVMDFTELTVPEAFIQKIGHAFSFFVLTYLLWKQRGSIRSAAAGSFAFAFFTEVLQLF FSRNGCIRDVLIDAVGIGLFYGLYVLAKRRKQEMYEKY*" /label="ywnJ CDS" gene complement(3243483..3243905) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /label="ywnJ gene" downshifts complement(3243502) /Source="Nicolas_upshifts" /id="D1889" /incds=0 /nref=9 /ntot=75 /MaxReadThrough="0.80227" /MaxDrop="3.65224" /score="4.98901321" /energy="-13.6" /TU="NA" /idTUdmin="U2869" /TUdmin=215 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3243940..3243955) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3243959) /Source="Nicolas_upshifts" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3243968..3243977) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3244016..3244867) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /function="16.8: Protect" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore protein required for alternative engulfment" /protein_id="NP_391536.1" /db_xref="EnsemblGenomes-Gn:BSU36550" /db_xref="EnsemblGenomes-Tr:CAB15672" /db_xref="GOA:P71044" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11978" /db_xref="UniProtKB/Swiss-Prot:P71044" /translation="MREEEKKTSQVKKLQQFFRKRWVFPAIYLVSAAVILTAVLWYQS VSNDEVKDQLADNGGNSAYDNNDDAVEVGKSMENVAMPVVDSENVSVVKKFYETDAAK EEKEAALVTYNNTYSLSKGIDLAEKDGKDFDVSASLSGTVVKAEKDPVLGYVVEVEHA DGLSTVYQSLSEVSVEQGDKVKQNQVIGKSGKNLYSEDSGNHVHFEIRKDGVAMNPLN FMDKPVSSIEKAATQETEESIQQSSEKKDGSTEKGTEEKSGEKKDDSTDKSGSKESST TEDTEQS*" /label="spoIIQ CDS" gene complement(3244016..3244867) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /label="spoIIQ gene" downshifts complement(3244025) /Source="Nicolas_upshifts" /id="D1890" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.592" /MaxDrop="5.16472" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts complement(3244267) /Source="Nicolas_upshifts" /id="D1891" /incds=1 /nref=4 /ntot=59 /MaxReadThrough="6.6416" /MaxDrop="3.0034" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" promotor_-35 3244504..3244506 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3244523..3244542 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3244524..3244870 /Source="Nicolas_S_feature" /locus_tag="new_3760210_3760556" /HighExp="LBGstat, LBGtran, Cold, Sw, dia15, C30, G180, Lbexp, LBGexp, UNK1" /AntisenseName="spoIIQ" /AntisenseCor="-0.81767802234568998" /AntisenseRegPval="-65.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1406" upshifts 3244524 /Source="Nicolas_upshifts" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3244862..3244865 /Source="Nicolas_upshift_promotors" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3244872..3245007 /Source="Nicolas_S_feature" /locus_tag="new_3760558_3760693" /HighExp="LBGstat, S8, LBGtran, Sw, LoTm, BC, Cold, S7, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.122, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1407" upshifts 3244872 /Source="Nicolas_upshifts" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3244901) /Source="Nicolas_upshifts" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3244907..3244916) /Source="Nicolas_upshift_promotors" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3245008..3245499 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /EC_number="2.3.1.183" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 16021622, 27694229; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacid analogs (phosphinothricin) N-acetyltransferase" /protein_id="NP_391537.1" /db_xref="EnsemblGenomes-Gn:BSU36560" /db_xref="EnsemblGenomes-Tr:CAB15673" /db_xref="GOA:P71043" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1VHS" /db_xref="SubtiList:BG12486" /db_xref="UniProtKB/Swiss-Prot:P71043" /translation="MTLRLAEHRDLEAVVAIYNSTIASRMVTADTEPVTPEDRMEWFS GHTESRPLYVAEDENGNVAAWISFETFYGRPAYNKTAEVSIYIDEACRGKGVGSYLLQ EALRIAPNLGIRSLMAFIFGHNKPSLKLFEKHGFAEWGLFPGIAEMDGKRYDLKILGR ELS*" /label="ywnH CDS" gene 3245008..3245499 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /label="ywnH gene" promotor_-35 3245237..3245242 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3245258..3245276 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3245269 /Source="Nicolas_upshifts" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3245360..3246268) /Source="Nicolas_S_feature" /locus_tag="new_3761046_3761954_c" /HighExp="H2O2, dia15, Diami, dia5, S8, Paraq, G180, G135, C30, G150" /AntisenseName="ywnG" /AntisenseCor="0.27407310266030799" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S1408" CDS 3245496..3246014 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391538.1" /db_xref="EnsemblGenomes-Gn:BSU36570" /db_xref="EnsemblGenomes-Tr:CAB15674" /db_xref="GOA:P71042" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12485" /db_xref="UniProtKB/Swiss-Prot:P71042" /translation="MISLDKDENEIEHHNEENSLVEQETAPVGQESRQLSASAVKSLS DIAKWGKISGILLIIMGSLVTLSVLMTVIGAIPGVLLIISGVFLMRSAKAAAEAEGNL TGSAGESMLENYGTFIKMQLFYAASSIVTVLIGIIVAIFVLVVIGIAAFENTPSYDDP DSYYYEDDPVFE*" /label="ywnG CDS" gene 3245496..3246014 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /label="ywnG gene" downshifts 3245819 /Source="Nicolas_upshifts" /id="D1892" /incds=1 /nref=1 /ntot=29 /MaxReadThrough="4.194" /MaxDrop="1.82458" /score="-3.39058903" /energy="-13.3" /TU="U2867,U2868,U2870" /idTUdmin="U2868" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 3246017 /Source="Nicolas_upshifts" /id="D1893" /incds=0 /nref=3 /ntot=133 /MaxReadThrough="2.87136" /MaxDrop="2.9486" /score="-3.39058903" /energy="-13.3" /TU="U2867" /idTUdmin="U2870" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3246173..3246304 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514007.1" /translation="MNIKKTDEVGINPKPHFLFRVSACKKTHPDRLENLNNPGADLL* " /label="hypothetical protein CDS" gene 3246173..3246304 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /label="gene" CDS complement(3246301..3246735) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391539.1" /db_xref="EnsemblGenomes-Gn:BSU36580" /db_xref="EnsemblGenomes-Tr:CAB15675" /db_xref="GOA:P71041" /db_xref="InterPro:IPR020205" /db_xref="SubtiList:BG12484" /db_xref="UniProtKB/Swiss-Prot:P71041" /translation="MNFYRVEQMPGFIKTEMQKIQKAVQPFMKKTVIYRFLAIPLAAF SLFNLAAFLFHASADRESLISAGIFALLAALGLAFFKEAGYQHKQIQKTVHIYMLNRI KKSEILSEERKSSYARQIKEEPFAMRSFVEFLTEEDRRKKMY*" /label="ywnF CDS" gene complement(3246301..3246735) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /label="ywnF gene" downshifts complement(3246313) /Source="Nicolas_upshifts" /id="D1894" /incds=0 /nref=174 /ntot=254 /MaxReadThrough="4.22489" /MaxDrop="5.35802" /score="21.5198482" /energy="-21.3" /TU="U2871" /idTUdmin="U2873" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3246784..3246803) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3246791) /Source="Nicolas_upshifts" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3246793..3247090) /Source="Nicolas_S_feature" /locus_tag="new_3762479_3762776_c" /HighExp="Etha, S6, S3, S4, S8, S5, S7, M9-stat, Sw, Salt" /AntisenseName="clsA" /AntisenseCor="-0.16109419145114601" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF" /TUshortPSig="0.99, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1409" promotor_-35 complement(3246818..3246825) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3246864..3246868 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3246885..3246904 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3246897..3246977 /Source="Nicolas_S_feature" /locus_tag="new_3762583_3762663" /HighExp="LBGstat, Diami, dia15, G180, Oxctl, H2O2, T0.30H, S8, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1410" upshifts 3246898 /Source="Nicolas_upshifts" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="upshifts" CDS 3246978..3248426 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14973018, 16755131, 18820022, 26708983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16755131, 18820022, 26708983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cardiolipin synthase (major)" /protein_id="NP_391540.1" /db_xref="EnsemblGenomes-Gn:BSU36590" /db_xref="EnsemblGenomes-Tr:CAB15676" /db_xref="GOA:P71040" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG12483" /db_xref="UniProtKB/Swiss-Prot:P71040" /translation="MSISSILLSLFFILNILLAIIVIFKERRDASASWAWLLVLFFIP VLGFILYLLFGHNLRRKHLFQWEDRKKIGIERLLKHQLEDLETKQFQFNNRATFDNKD LIYMLIMNNHAVFTEDNSVDVITDGRDKFQRLLSDISKAKDHIHLQYYIYKGDELGKK LRDALIQKAKEGVQVRVLYDELGSRTLRKKFFKELREAGGHVEVFFPSKLRPINLRLN YRNHRKLVIIDGMTGYVGGFNVGDEYLGLNPKFGYWRDTHIRLQGTAVHAIQTRFILD WNQASHHHTLTYIPNHFPDYGPKGNVGMQIVTSGPDSEWEQIKNGYIKMISNAKRSIL IQTPYFIPDASLLDALRIACLSGIDVNIMIPNKPDHAFVYWATLSYIGDLLKAGATVY IYDNGFIHAKTIVVDDEIASVGTANIDVRSFRLNFEVNAFIYDITIAKKLVSTFKEDL LVSRKFTYEEYLQRPLWIRIKESVSRLLSPIL*" /label="clsA CDS" gene 3246978..3248426 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /label="clsA gene" upshifts complement(3247090) /Source="Nicolas_upshifts" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3247091..3247109) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(3247092..3247435) /Source="Nicolas_S_feature" /locus_tag="new_3762778_3763121_c" /HighExp="S6, S8, S4, S5, S7, S3, T5.0H, M9-stat, C30, T4.0H" /AntisenseName="clsA" /AntisenseCor="3.3648966966722899E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1411" promotor_-35 complement(3247125..3247131) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3247413..3247431) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3247435) /Source="Nicolas_upshifts" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3247447..3247452) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3248415 /Source="Nicolas_upshifts" /id="D1895" /incds=0 /nref=6 /ntot=214 /MaxReadThrough="0.7051" /MaxDrop="4.44298" /score="26.7449315" /energy="-19.5" /TU="NA" /idTUdmin="U2872" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3248447..3249220) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10200972, 11581256, 18502870" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 11581256, 18502870; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulating efflux transporters synthesis (Fur-independent bacillibactin export)" /protein_id="NP_391541.1" /db_xref="EnsemblGenomes-Gn:BSU36600" /db_xref="EnsemblGenomes-Tr:CAB15677" /db_xref="GOA:P71039" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012925" /db_xref="InterPro:IPR036244" /db_xref="PDB:1JBG" /db_xref="PDB:1R8D" /db_xref="SubtiList:BG12482" /db_xref="UniProtKB/Swiss-Prot:P71039" /translation="MKYQVKQVAEISGVSIRTLHHYDNIELLNPSALTDAGYRLYSDA DLERLQQILFFKEIGFRLDEIKEMLDHPNFDRKAALQSQKEILMKKKQRMDEMIQTID RTLLSVDGGETMNKRDLFAGLSMKDIEEHQQTYADEVRKLYGKEIAEETEKRTSAYSA DDWRTIMAEFDSIYRRIAARMKHGPDDAEIQAAVGAFRDHICQYHYDCTLDIFRGLGE VYITDERFTDSINQYGEGLAAFLREAIIIYCDHQENPRP*" /label="mta CDS" gene complement(3248447..3249220) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /label="mta gene" downshifts complement(3248469) /Source="Nicolas_upshifts" /id="D1896" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="0.46006" /MaxDrop="2.97389" /score="11.4339746" /energy="-19.5" /TU="NA" /idTUdmin="U2876" /TUdmin=1342 /isTUend="FALSE" /label="downshifts" promotor_-35 3249295..3249298 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3249314..3249333 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3249318 /Source="Nicolas_upshifts" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="upshifts" CDS 3249365..3249748 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391542.1" /db_xref="EnsemblGenomes-Gn:BSU36610" /db_xref="EnsemblGenomes-Tr:CAB15678" /db_xref="GOA:P71038" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12481" /db_xref="UniProtKB/Swiss-Prot:P71038" /translation="MNPETMNKTLISISKWGKATGILFIIMGAITALSGAFFFLIGAV PGVLQIISGIFLMRSAREAGQMAEHNSGQSEDLMLENYAKFVKMQGIYLIVSIAVSIL AIIAFFIFLMLGIADGLFSDTYSTY*" /label="ywnC CDS" gene 3249365..3249748 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /label="ywnC gene" downshifts 3249735 /Source="Nicolas_upshifts" /id="D1897" /incds=0 /nref=60 /ntot=180 /MaxReadThrough="1.0319" /MaxDrop="4.45212" /score="35.5991488" /energy="-11.4" /TU="NA" /idTUdmin="U2875" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3249783..3250424) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391543.1" /db_xref="EnsemblGenomes-Gn:BSU36620" /db_xref="EnsemblGenomes-Tr:CAB15679" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12480" /db_xref="UniProtKB/Swiss-Prot:P71037" /translation="MKIGIIGASGKAGNEILKEAKKRGHEVTAIVRNASKVQEQDVAI LEKDVFELTAEDIKPFDAVVNAFGAAPGQEHLHVEAGRALISILKDAKHTRLLVVGGA GSLFVDEAKTTRLMDTPEFPKEYLPTASNQGENLKDLQQTDSISWTFLSPAAFFDPAG KRTGSYQKGKDNVIVNAKGDSYISYADYAIAVLDELEHPEHKNERFTVVSEAE*" /label="ywnB CDS" gene complement(3249783..3250424) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /label="ywnB gene" downshifts complement(3249833) /Source="Nicolas_upshifts" /id="D1898" /incds=0 /nref=20 /ntot=170 /MaxReadThrough="3.62026" /MaxDrop="4.98934" /score="21.1363072" /energy="-11.4" /TU="U2876" /idTUdmin="U2876" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(3250492..3250893) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391544.1" /db_xref="EnsemblGenomes-Gn:BSU36630" /db_xref="EnsemblGenomes-Tr:CAB15680" /db_xref="GOA:P71036" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1XD7" /db_xref="SubtiList:BG12479" /db_xref="UniProtKB/Swiss-Prot:P71036" /translation="MINSRLAVAIHILSLISMDEKTSSEIIADSVNTNPVVVRRMISL LKKADILTSRAGVPGASLKKDPADISLLEVYRAVQKQEELFAVHENPNPKCPVGKKIQ NALDETFESVQRAMENELASKSLKDVMNHLF*" /label="ywnA CDS" gene complement(3250492..3250893) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /label="ywnA gene" promotor_-10 complement(3250942..3250961) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3250952) /Source="Nicolas_upshifts" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3250954..3251027) /Source="Nicolas_S_feature" /locus_tag="new_3766640_3766713_c" /HighExp="BT, Etha, S1, B60, LoTm, B36, S2, Glucon, Sw, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.18507799999999999" /TUshortSig="Sig-" /TUshortPSig="0.106" /TUlongSig="SigH, SigA, SigB, SigB" /TUlongPSig="1, 0.993, 1, 0.995" /label="S1412" promotor_-35 complement(3250976..3250981) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3251028..3252737) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (alpha subunit)" /protein_id="NP_391545.1" /db_xref="EnsemblGenomes-Gn:BSU36640" /db_xref="EnsemblGenomes-Tr:CAB15681" /db_xref="GOA:P77837" /db_xref="InterPro:IPR005848" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR011612" /db_xref="InterPro:IPR017950" /db_xref="InterPro:IPR017951" /db_xref="InterPro:IPR029754" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11983" /db_xref="UniProtKB/Swiss-Prot:P77837" /translation="MKMSREEYAELFGPTTGDKIRLGDTDLWIEVEKDFTVYGEEMIF GGGKTIRDGMGQNGRITGKDGALDLVITNVVLLDYTGIVKADVGVKDGRIVGVGKSGN PDIMDGVDPHMVIGAGTEVISGEGKILTAGGVDTHIHFICPQQMEVALSSGVTTLLGG GTGPATGSKATTCTSGAWYMARMLEAAEEFPINVGFLGKGNASDKAPLIEQVEAGAIG LKLHEDWGTTPSAIKTCMEVVDEADIQVAIHTDTINEAGFLENTLDAIGDRVIHTYHI EGAGGGHAPDIMKLASYANILPSSTTPTIPYTVNTMDEHLDMMMVCHHLDAKVPEDVA FSHSRIRAATIAAEDILHDIGAISMTSSDSQAMGRVGEVIIRTWQVADKMKKQRGALA GENGNDNVRAKRYIAKYTINPAITHGLSHEVGSVEKGKLADLVLWDPVFFGVKPELVL KGGMIARAQMGDPNASIPTPEPVFMRQMYASYGKANRSTSITFMSQASIERGVAESLG LEKRISPVKNIRKLSKLDMKLNSALPKIEIDPKTYQVFADGEELSCQPVDYVPLGQRY FLF*" /label="ureC CDS" gene complement(3251028..3252737) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /label="ureC gene" CDS complement(3252734..3253108) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (beta subunit)" /protein_id="NP_391546.1" /db_xref="EnsemblGenomes-Gn:BSU36650" /db_xref="EnsemblGenomes-Tr:CAB15682" /db_xref="GOA:P71035" /db_xref="InterPro:IPR002019" /db_xref="InterPro:IPR036461" /db_xref="SubtiList:BG11982" /db_xref="UniProtKB/Swiss-Prot:P71035" /translation="MKPGAFQIAEGTITINEGREIREVTVKNTGSRSIQVGSHFHFAE ANGALLFDRELAIGMRLDVPSGTSVRFEPGEQKTVSLVEIRGRKTIRGLNGMADTFID ERGKEKTLANLKQAGWMEGVIR*" /label="ureB CDS" gene complement(3252734..3253108) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /label="ureB gene" CDS complement(3253105..3253422) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /EC_number="3.5.1.5" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (gamma subunit)" /protein_id="NP_391547.1" /db_xref="EnsemblGenomes-Gn:BSU36660" /db_xref="EnsemblGenomes-Tr:CAB15683" /db_xref="GOA:P75030" /db_xref="InterPro:IPR002026" /db_xref="InterPro:IPR012010" /db_xref="InterPro:IPR036463" /db_xref="SubtiList:BG11981" /db_xref="UniProtKB/Swiss-Prot:P75030" /translation="MKLTPVEQEKLLIFAAGELAKQRKARGVLLNYPEAAAYITCFIM EGARDGKGVAELMEAGRHVLTEKDVMEGVPEMLDSIQVEATFPDGVKLVTVHQPISAE VKS*" /label="ureA CDS" gene complement(3253105..3253422) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /label="ureA gene" S_feature complement(3253423..3253507) /Source="Nicolas_S_feature" /locus_tag="new_3769109_3769193_c" /HighExp="BT, B60, B36, S1, Etha, LoTm, M9-stat, S2, T0.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigH, SigB" /TUshortPSig="0.106, 1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1413" upshifts complement(3253507) /Source="Nicolas_upshifts" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3253509..3253522) /Source="Nicolas_upshift_promotors" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(3253509..3253602) /Source="Nicolas_S_feature" /locus_tag="new_3769195_3769288_c" /HighExp="BT, Etha, B60, S1, B36, BC, S2, LoTm, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30781199999999997" /TUshortSig="SigH, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1414" CDS complement(3253603..3253767) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (putative phage interference protein)" /protein_id="YP_009514008.1" /translation="MVNLKNILLNKQLEGIQILIVELVRQVIIEISRKKDICYLSRAQ SGKRVNLIFP*" /label="ywzE CDS" gene complement(3253603..3253767) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /label="ywzE gene" promotor_-10 complement(3253690..3253708) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-10" upshifts complement(3253702) /Source="Nicolas_upshifts" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="upshifts" promotor_-35 complement(3253720..3253728) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-35" S_feature complement(3253768..3253939) /Source="Nicolas_S_feature" /locus_tag="new_3769454_3769625_c" /HighExp="Etha, BT, S1, GM-0.2, GM-0.1, Salt, GM 5, T-5.40H, MG 60, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1415" CDS complement(3253940..3254122) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="PSEUDO:CAX52705.1" /translation="MKAGILHSLRGTVAISEVTVHDAELMAIVGFSVSWRSAPQTGLH AMLPVAEQNNGLPSGM*" /label="ywzF CDS" gene complement(3253940..3254122) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /pseudo /label="ywzF gene" S_feature complement(3254123..3254269) /Source="Nicolas_S_feature" /locus_tag="new_3769809_3769955_c" /HighExp="Etha, BT, S1, Salt, GM-0.2, GM-0.1, M9-stat, GM 5, GM 45, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15897800000000001" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1416" promotor_-10 complement(3254257..3254276) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3254269) /Source="Nicolas_upshifts" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="upshifts" S_feature complement(3254271..3254385) /Source="Nicolas_S_feature" /locus_tag="new_3769957_3770070_c" /HighExp="Etha, Salt, M9-stat, S8, B60, B36, Sw, Gly, LoTm, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1417" promotor_-35 complement(3254291..3254298) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" Polymorphism join(3254372,3254374) /Source="geneious" /ID="SNP_BsDelta6_3770059_3770058" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(A)8 -> (A)9" /Codon_Change /Coverage=64 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="A" /Variant_P_Value="2.1e-197" /Variant_Raw_Frequency=61 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" upshifts 3254399 /Source="Nicolas_upshifts" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3254402..3254406 /Source="Nicolas_upshift_promotors" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3254419..3254607) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10376822, 11988534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376822, 11988534; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein" /protein_id="NP_391548.1" /db_xref="EnsemblGenomes-Gn:BSU36670" /db_xref="EnsemblGenomes-Tr:CAB15684" /db_xref="InterPro:IPR008462" /db_xref="InterPro:IPR036629" /db_xref="SubtiList:BG12478" /db_xref="UniProtKB/Swiss-Prot:P70964" /translation="MGNDSVKDKMKGGFNKAKGEVKDKVGDMADRTDMQAEGKKDKAK GEIQKDIGKAKDKFSDKD*" /label="csbD CDS" gene complement(3254419..3254607) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /label="csbD gene" downshifts complement(3254430) /Source="Nicolas_upshifts" /id="D1899" /incds=0 /nref=69 /ntot=139 /MaxReadThrough="6.39376" /MaxDrop="6.75256" /score="21.8463823" /energy="-10.2" /TU="U2881" /idTUdmin="U2882" /TUdmin=221 /isTUend="FALSE" /label="downshifts" downshifts 3254597 /Source="Nicolas_upshifts" /id="D1900" /incds=0 /nref=15 /ntot=36 /MaxReadThrough="0.59322" /MaxDrop="5.27268" /score="-5.47050177" /energy="-8.1" /TU="NA" /idTUdmin="U2880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3254633..3254651) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3254644) /Source="Nicolas_upshifts" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="upshifts" promotor_-35 complement(3254665..3254671) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3254680..3255180) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391549.2" /db_xref="EnsemblGenomes-Gn:BSU36680" /db_xref="EnsemblGenomes-Tr:CAB15685" /db_xref="GOA:P70963" /db_xref="SubtiList:BG12477" /db_xref="UniProtKB/Swiss-Prot:P70963" /translation="MHVRGNSMFGFNDMVKFLWSFLIVLPLVQIIHVSGHSFMAFIFG GKGSLDIGMGKTLLKIGPIRFRTIYFIDSFCRYGELKIDNRFSNALVYAGGCLFNLIT IFAINLLIIHSVLKPNVFFYQFVYFSTYYVFFALLPVRYSEKKSSDGLAIYKVLRYGE RYEIDK*" /label="ywmF CDS" gene complement(3254680..3255180) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /label="ywmF gene" promotor_-10 complement(3255216..3255235) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3255223) /Source="Nicolas_upshifts" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="upshifts" promotor_-35 complement(3255249..3255255) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3255315..3256448) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9843420, 10629174, 12875849, 19332814, 19684115" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9843420, 10629174, 12875849, 19332814, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391550.1" /db_xref="EnsemblGenomes-Gn:BSU36690" /db_xref="EnsemblGenomes-Tr:CAB15686" /db_xref="GOA:P70962" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11965" /db_xref="UniProtKB/Swiss-Prot:P70962" /translation="MAAYEIPSSQVGVKINKWYKHILAFQVADAVKLKEEIDLDIEQM EEDQLLLLYYQLISYRHQIMLDYVKPDLHEESQLQYRELIKTLESNQDSISGLSEYYF HLFRGMYEFEQNNYISAISFYRKAEKMLAFVEDEIERAEFHFKVAEVFYIMKQTHFSM NHAVQALETYKAHDFYRVRRIQCHFVISGNYIDYRNYEKALEHLDDAYRLALLEGQPR LIGSALYNIGNCYDDKGELDQAAEYFEKALPVFEDYQLEQLPKALFSLTRVLFKKQDS EAAIRYYEKGIAIAQKRNDFFSLAKYKFLQALYVESVNLNMIQEVFDYMEEKGLYVYI EEFALDAASYFSHREQYKEAVYFYEKAVSMREMIQRNDCLYEV*" /label="rapB CDS" gene complement(3255315..3256448) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /label="rapB gene" downshifts complement(3255333) /Source="Nicolas_upshifts" /id="D1901" /incds=0 /nref=244 /ntot=265 /MaxReadThrough="2.8683" /MaxDrop="6.81344" /score="30.5146793" /energy="-8.1" /TU="NA" /idTUdmin="U2883" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(3256475..3256494) /Source="Nicolas_upshift_promotors" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3256482) /Source="Nicolas_upshifts" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3256545..3256563) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3256561) /Source="Nicolas_upshifts" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3256577..3256584) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3256640..3257665) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /EC_number="4.1.99.22" /function="16.10: Respire" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170340, 7860592, 16632608, 19566093, 23286307, 25896388, 25941396, 26575208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP 3',8-cyclase" /protein_id="NP_391551.1" /db_xref="EnsemblGenomes-Gn:BSU36700" /db_xref="EnsemblGenomes-Tr:CAB15687" /db_xref="GOA:P39757" /db_xref="InterPro:IPR000385" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010505" /db_xref="InterPro:IPR013483" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034395" /db_xref="InterPro:IPR034481" /db_xref="SubtiList:BG10980" /db_xref="UniProtKB/Swiss-Prot:P39757" /translation="MITESRQMLDKRNRPLRDLRISVTDRCNFRCTYCMPAELFGPDY PFLKKEELLSFEELERLATLFVTRFGVEKIRLTGGEPLMRKDMPELIKKLARIPGIRD IAMTTNGSLLPVYAKRLKEAGLKRVTISLDSLEDERFKKINGRGVSVSKVLEGIEAAK QAGLGVKINMVVQKGVNEKDILPMARYFKEKGHILRFIEFMDVGNTNQWEKKDVMTKA EIIDLINKHMPVEPIAPNYIGEVASRFRYLDGSGEIGVISSVSDAFCGSCNRARLSAR GELFTCLFASSGFDLRAPVRQELSDDELSEMIGTVWKNRIDQYSVDRTLSKASGKKKV EMSYIGG*" /label="moaA CDS" gene complement(3256640..3257665) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /label="moaA gene" downshifts complement(3256653) /Source="Nicolas_upshifts" /id="D1902" /incds=0 /nref=23 /ntot=147 /MaxReadThrough="3.05546" /MaxDrop="3.66108" /score="13.625744" /energy="-10.8" /TU="NA" /idTUdmin="U2885" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3257681..3258469) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /function="16.11: Scavenge (Catabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2170340, 7860592, 19114526, 20011599, 22194618; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein sulfur transferase involved in molybdenum cofactor synthesis" /protein_id="NP_391552.1" /db_xref="EnsemblGenomes-Gn:BSU36710" /db_xref="EnsemblGenomes-Tr:CAB15688" /db_xref="GOA:P39756" /db_xref="InterPro:IPR003786" /db_xref="InterPro:IPR016193" /db_xref="SubtiList:BG10979" /db_xref="UniProtKB/Swiss-Prot:P39756" /translation="MNDKVTAVRDVWRYEQGEISKVEDRMVTEFPLTVILNGSEFVTL VCTPEHIEELVIGFLASEGVIRFQKEIKRFTIDESLGFVYVDLVHPETLDQKDYTKRV IGSCCGKGRHFYFQQDVKTAKTAVSQIKISPEACLALMKDMQQGSGTFQDTGGVHNAA LCDTEKLLLMRTDIGRHNALDKLYGHCLLNGMSVRDKLIVFSGRISSEVLLKAAKIGV SIVISKSAPTELAIQMAEELNITAIGFVRNGSFNVYTHPERIRE*" /label="fdhD CDS" gene complement(3257681..3258469) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /label="fdhD gene" promotor_-10 complement(3258495..3258514) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3258501) /Source="Nicolas_upshifts" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3258503..3258714) /Source="Nicolas_S_feature" /locus_tag="new_3774188_3774399_c" /HighExp="Etha, Sw, Salt, Heat, S8, Gly, S6, S7, BC, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16930300000000001" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1418" promotor_-35 complement(3258528..3258535) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3258715..3258876) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391553.1" /db_xref="EnsemblGenomes-Gn:BSU36720" /db_xref="EnsemblGenomes-Tr:CAB15689" /db_xref="GOA:P70966" /db_xref="SubtiList:BG12476" /db_xref="UniProtKB/Swiss-Prot:P70966" /translation="MKLFGMIFLIATVAFILLGVLLKLAAFFFVSILTLIAAIVLFTV LKKNQHNQT*" /label="ywmE CDS" gene complement(3258715..3258876) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /label="ywmE gene" promotor_-10 complement(3258889..3258907) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-10" upshifts complement(3258909) /Source="Nicolas_upshifts" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="upshifts" promotor_-35 complement(3258921..3258927) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-35" CDS complement(3258970..3259644) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391554.1" /db_xref="EnsemblGenomes-Gn:BSU36730" /db_xref="EnsemblGenomes-Tr:CAB15690" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12475" /db_xref="UniProtKB/Swiss-Prot:P70961" /translation="MKKLLAAGIIGLLTVSIASPSFAAEKQADTNVAVLFDGSGSMVQ KTGGERKIDIAKKSVKSFAELLPKDTNLMLRVFGHAGNNKLSGKALSCSTTETIYGLH PYEGSLFDNSLSELKPTGWTPIAKALADTRKEFEAFDADGKNVVYLITDGEETCGGDP AAEIEKLRASNVDTIVNIIGFNFDVKGNEEMKQAAVAGGGEYISANSADEFEQAWEKE AQKFTE*" /label="ywmD CDS" gene complement(3258970..3259644) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /label="ywmD gene" downshifts complement(3258985) /Source="Nicolas_upshifts" /id="D1903" /incds=0 /nref=16 /ntot=88 /MaxReadThrough="0.76221" /MaxDrop="4.19611" /score="25.2461653" /energy="-9.6" /TU="NA" /idTUdmin="U2886" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(3259697..3259837) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514009.1" /translation="MITQAVYAFWAEMAKNERHFKRFWTDRESSTKGSMSYIFLHFRI LA*" /label="hypothetical protein CDS" gene complement(3259697..3259837) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /label="gene" CDS complement(3259968..3260651) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391555.1" /db_xref="EnsemblGenomes-Gn:BSU36740" /db_xref="EnsemblGenomes-Tr:CAB15691" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12474" /db_xref="UniProtKB/Swiss-Prot:P70960" /translation="MKKRFSLIMMTGLLFGLTSPAFAAEKTETEAKAPANVAVLLDAS GSMAKRIDGVSKFNSAKKEISKFASSLPEGTQVKMSVFGSEGNNKNSGKVQSCEAIRN VYGFQSFNEQSFLNSLNTIGPTGWTPIAKALNEAKSSFDQLDAKGEKVVYLLTDGEET CGGNPIKTAKELQKDNITVNVIGFDYKEGYKGQLNAIAKVGGGEYFPAYTQKDVEKIF TQQSLMLSK*" /label="ywmC CDS" gene complement(3259968..3260651) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /label="ywmC gene" promotor_-35 3261028..3261032 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3261037..3262068) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15752199, 16959571, 17376078, 27226615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15752199, 16959571, 17376078, 27226615; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="lytic transglycosylase; autolysin required for complete dissolution of the asymmetric septum (stage II sporulation)" /protein_id="NP_391556.1" /db_xref="EnsemblGenomes-Gn:BSU36750" /db_xref="EnsemblGenomes-Tr:CAB15692" /db_xref="GOA:P07372" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="InterPro:IPR014225" /db_xref="SubtiList:BG10766" /db_xref="UniProtKB/Swiss-Prot:P07372" /translation="MKQFAITLSVLCALILLVPTLLVIPFQHNKEAGASVESEKTAVS TKPASKGAETLKASPVSIPVYRTANQSVENIPLEEYVIGVVASEMPATFKPEALKAQA LAARTFIVRLMVSNSAVEAPKGSLVDDTQMFQVYKSKAELKKQWGTSYETKLKKITDA VASTQGKILTYNNQPIEASFFSTSNGYTENAEAYWTSAIPYLKSVKSPWDKKSPKYKA TKTFTAAEFQQKLGVKLDGSSAVGKITGETPGHQVATAVINGKTLKGRDIREKLGLNS ADFEWKRNGDTITVTTRGFGHGVGMSQYGANFMAKEGKTVDDIVKYYYQGTQISEADA FLNKYMAKK*" /label="spoIID CDS" gene complement(3261037..3262068) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /label="spoIID gene" promotor_-10 3261047..3261066 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3261053) /Source="Nicolas_upshifts" /id="D1904" /incds=0 /nref=56 /ntot=156 /MaxReadThrough="0.87893" /MaxDrop="6.31542" /score="12.1351765" /energy="-8.7" /TU="NA" /idTUdmin="U2888" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts 3261065 /Source="Nicolas_upshifts" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3262096..3262114) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3262109) /Source="Nicolas_upshifts" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3262111..3262228) /Source="Nicolas_S_feature" /locus_tag="new_3777796_3777913_c" /HighExp="S8, M40t90, M9-stat, B36, LBGtran, G180, H2O2, M0t90, BT, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigI, SigWXY, SigA" /TUshortPSig="0.947, 0.999, 1, 0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1419" promotor_-35 complement(3262130..3262135) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3262170..3262175 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3262187..3264847 /Source="Nicolas_S_feature" /locus_tag="new_3777872_3780532" /HighExp="S8, S6, S7, S4, S3, C30, S5, T5.0H, T3.30H, BT" /AntisenseName="murAA" /AntisenseCor="5.8371061376981899E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.971" /TUlongSig="NA" /TUlongPSig="NA" /label="S1420" upshifts 3262187 /Source="Nicolas_upshifts" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3262191..3262209 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3262264..3263574) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /EC_number="2.5.1.7" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 14763982, 17714441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14763982, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391557.1" /db_xref="EnsemblGenomes-Gn:BSU36760" /db_xref="EnsemblGenomes-Tr:CAB15693" /db_xref="GOA:P70965" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG11955" /db_xref="UniProtKB/Swiss-Prot:P70965" /translation="MEKIIVRGGQKLNGTVKVEGAKNAVLPVIAASLLASEEKSVICD VPTLSDVYTINEVLRHLGADVHFENNEVTVNASYALQTEAPFEYVRKMRASVLVMGPL LARTGHARVALPGGCAIGSRPIDQHLKGFEAMGAEIKVGNGFIEAEVKGRLQGAKIYL DFPSVGATENLIMAAALAEGTTTLENVAKEPEIVDLANYINGMGGKIRGAGTGTIKIE GVEKLHGVKHHIIPDRIEAGTFMVAAAITEGNVLVKGAVPEHLTSLIAKMEEMGVTIK DEGEGLRVIGPKELKPIDIKTMPHPGFPTDMQSQMMALLLRASGTSMITETVFENRFM HAEEFRRMNGDIKIEGRSVIINGPVQLQGAEVAATDLRAGAALILAGLVAEGHTRVTE LKHLDRGYVDFHQKLAALGADIERVNDESASEQENKEVVSDLNA*" /label="murAA CDS" gene complement(3262264..3263574) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /label="murAA gene" downshifts complement(3262273) /Source="Nicolas_upshifts" /id="D1905" /incds=0 /nref=171 /ntot=256 /MaxReadThrough="5.3301" /MaxDrop="5.5423" /score="31.3825723" /energy="-11.8" /TU="U2890,U2891,U2892,U2894" /idTUdmin="U2890" /TUdmin="-98" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3263598..3263617) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3263605) /Source="Nicolas_upshifts" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3263608..3264348) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391558.1" /db_xref="EnsemblGenomes-Gn:BSU36770" /db_xref="EnsemblGenomes-Tr:CAB15694" /db_xref="InterPro:IPR014794" /db_xref="InterPro:IPR036209" /db_xref="PDB:2FPN" /db_xref="SubtiList:BG12473" /db_xref="UniProtKB/Swiss-Prot:O32277" /translation="MKKKQVSHAIIISVMLSFVIAVFHTIHASELTPLAQMAEGMERQ DVSIDKWTLHAKQNLSLTEKEFYQKVQRLKQEYRQYDWVIAREDKMIKAIGTYTDKKN RTSFRLQLVTTLKKHNPTSYLLYEQMSLETPDSWNDTYEQFERETLGIFQEKVVIFTC LNGHLDDNMNIVLQKKANQLLNEFQARSVEHVVEPNFVSISAFTDEWEEYIMTSKHKM NLQIALRSAGMGGKHTVTVGTPIVTTEY*" /label="ywmB CDS" gene complement(3263608..3264348) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /label="ywmB gene" promotor_-35 complement(3263631..3263640) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3263979) /Source="Nicolas_upshifts" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3263981..3263989) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3264003..3264011) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3264103..3264118) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3264111) /Source="Nicolas_upshifts" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3264131..3264140) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3264349..3264476) /Source="Nicolas_S_feature" /locus_tag="new_3780034_3780161_c" /HighExp="UNK1, S2, Lbexp, MG 60, MG 15, M9-tran, M/G, G135, MG 5, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1421" CDS complement(3264477..3264707) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391559.1" /db_xref="EnsemblGenomes-Gn:BSU36780" /db_xref="EnsemblGenomes-Tr:CAB15695" /db_xref="GOA:O32278" /db_xref="InterPro:IPR009526" /db_xref="SubtiList:BG14163" /db_xref="UniProtKB/Swiss-Prot:O32278" /translation="MSVLGQQAAIGIVVHLIFIAVTWWALQAVNIDPLIKKGKVVQAR LLMILLTIAIGTAVANFFLDYLNYSQQLPYLF*" /label="ywzB CDS" gene complement(3264477..3264707) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /label="ywzB gene" S_feature complement(3264708..3264970) /Source="Nicolas_S_feature" /locus_tag="new_3780393_3780655_c" /HighExp="UNK1, S2, Lbexp, MG 5, M9-tran, M/G, MG 15, MG 60, GM 15, MG t5" /AntisenseName="ywmA" /AntisenseCor="-0.24099136307237601" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1422" misc_feature 3264843..3264862 /Source="Nicolas_upshift_promotors" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3264849 /Source="Nicolas_upshifts" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="upshifts" CDS 3264877..3265350 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391560.1" /db_xref="EnsemblGenomes-Gn:BSU36790" /db_xref="EnsemblGenomes-Tr:CAB15696" /db_xref="SubtiList:BG12472" /db_xref="UniProtKB/Swiss-Prot:P70958" /translation="MNHSFFQPEKQYGEDLPIFDQEWEAIAFYYDYRQSQIEELNELC QFFNISLTYTRESLEELENLYFQSIQELLLADWNLPIEEFEKMISVYLIDCVIARHED AEWVVKPYPYKDGAYTLGFRRHRKSWHTMNACDGLYLRPKEDRPLLSLFDSLVRS*" /label="ywmA CDS" gene 3264877..3265350 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /label="ywmA gene" promotor_-10 complement(3264954..3264973) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-10" upshifts complement(3264970) /Source="Nicolas_upshifts" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="upshifts" S_feature complement(3264972..3265355) /Source="Nicolas_S_feature" /locus_tag="new_3780657_3781040_c" /HighExp="G135, G180, G150, H2O2, Oxctl, Paraq, Cold, M9-stat, C30, S0" /AntisenseName="ywmA" /AntisenseCor="-1.9581968147303098E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1423" promotor_-35 complement(3264988..3264991) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-35" CDS complement(3265384..3265782) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /EC_number="3.6.3.14" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8021203, 12837747, 15347741, 22720735, 23967352" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 12837747, 15347741, 22720735, 23967352; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit epsilon, F1 subunit)" /protein_id="NP_391561.1" /db_xref="EnsemblGenomes-Gn:BSU36800" /db_xref="EnsemblGenomes-Tr:CAB15697" /db_xref="GOA:P37812" /db_xref="InterPro:IPR001469" /db_xref="InterPro:IPR020546" /db_xref="InterPro:IPR020547" /db_xref="InterPro:IPR036771" /db_xref="InterPro:IPR036794" /db_xref="SubtiList:BG10822" /db_xref="UniProtKB/Swiss-Prot:P37812" /translation="MKTVKVNIVTPDGPVYDADIEMVSVRAESGDLGILPGHIPTVAP LKIGAVRLKKDGQTEMVAVSGGFVEVRPDHVTILAQAAETAEGIDKERAEAARQRAQE RLNSQSDDTDIRRAELALQRALNRLDVAGK*" /label="atpC CDS" gene complement(3265384..3265782) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /label="atpC gene" downshifts complement(3265400) /Source="Nicolas_upshifts" /id="D1906" /incds=0 /nref=283 /ntot=320 /MaxReadThrough="4.15968" /MaxDrop="7.84101" /score="22.7623678" /energy="-10.8" /TU="U2897,U2899" /idTUdmin="U2895" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3265774..3265792) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3265783) /Source="Nicolas_upshifts" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3265806..3265812) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3265806..3267227) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit beta, component F1)" /protein_id="NP_391562.1" /db_xref="EnsemblGenomes-Gn:BSU36810" /db_xref="EnsemblGenomes-Tr:CAB15698" /db_xref="GOA:P37809" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005722" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR024034" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10821" /db_xref="UniProtKB/Swiss-Prot:P37809" /translation="MKKGRVSQVLGPVVDVRFEDGHLPEIYNAIKISQPAASENEVGI DLTLEVALHLGDDTVRTIAMASTDGVQRGMEAVDTGAPISVPVGDVTLGRVFNVLGEN IDLNEPVPADAKKDPIHRQAPSFDQLSTEVEILETGIKVVDLLAPYIKGGKIGLFGGA GVGKTVLIQELINNIAQEHGGISVFAGVGERTREGNDLFYEMSDSGVINKTAMVFGQM NEPPGARMRVALTGLTMAEHFRDVQGQDVLFFIDNIFRFTQAGSEVSALLGRMPSAVG YQPTLATEMGQLQERITSTNVGSVTSIQAIYVPADDYTDPAPATTFAHLDATTNLERK LTEMGIYPAVDPLASTSRALAPEIVGEEHYAVAREVQSTLQRYKELQDIIAILGMDEL GEEDKLVVHRARRIQFFLSQNFHVAEQFTGQKGSYVPVKETVQGFKEILAGKYDHLPE DAFRLVGRIEEVVEKAKEMGVEV*" /label="atpD CDS" gene complement(3265806..3267227) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /label="atpD gene" CDS complement(3267253..3268116) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit gamma, component F1)" /protein_id="NP_391563.1" /db_xref="EnsemblGenomes-Gn:BSU36820" /db_xref="EnsemblGenomes-Tr:CAB15699" /db_xref="GOA:P37810" /db_xref="InterPro:IPR000131" /db_xref="InterPro:IPR023632" /db_xref="InterPro:IPR035968" /db_xref="SubtiList:BG10820" /db_xref="UniProtKB/Swiss-Prot:P37810" /translation="MASLRDIKSRITSTKKTSQITKAMQMVSAAKLNRAENNAKSFVP YMDKIQEVVSNVGRVSGNVKHPMLLSREVKKTAYLVITSDRGLAGAFNSSVLRSAYQA MQERHQSKDEYAVIAIGRVGRDFFKKREIPIISELTGLGDEVTFTEIKDLARQTIQMF IDGAFDELHLVYNHFVSAITQEVTEKKLLPLSDLGSGGGKRTASYEFEPSEEEVLEVL LPQYAESLIFGALLDSKASEHAARMTAMKNATDNAKELIDSLSLSYNRARQAAITQEI TEIVGGAAALE*" /label="atpG CDS" gene complement(3267253..3268116) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /label="atpG gene" S_feature complement(3268117..3268192) /Source="Nicolas_S_feature" /locus_tag="new_3783802_3783877_c" /HighExp="S0, S2, MG-0.2, MG-0.1, Mal, G150, BI, M0t45, G180, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1424" CDS complement(3268193..3269701) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit alpha, component F1)" /protein_id="NP_391564.1" /db_xref="EnsemblGenomes-Gn:BSU36830" /db_xref="EnsemblGenomes-Tr:CAB15700" /db_xref="GOA:P37808" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000793" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005294" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033732" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10819" /db_xref="UniProtKB/Swiss-Prot:P37808" /translation="MSIKAEEISTLIKQQIQNYQSDIEVQDVGTVIQVGDGIARVHGL DNCMAGELVEFSNGVLGMAQNLEESNVGIVILGPFSEIREGDEVKRTGRIMEVPVGEE LIGRIVNPLGQPVDGLGPILTSKTRPIESPAPGVMDRKSVHEPLQTGIKAIDALIPIG RGQRELIIGDRQTGKTSVAIDAILNQKDQDMICVYVAIGQKESTVRGVVETLRKHGAL DYTIVVTASASQPAPLLYLAPYAGVTMAEEFMYNGKHVLVVYDDLSKQAAAYRELSLL LRRPPGREAFPGDVFYLHSRLLERAAKLSDAKGAGSITALPFVETQAGDISAYIPTNV ISITDGQIFLQSDLFFSGVRPAINAGLSVSRVGGSAQIKAMKKVSGTLRLDLASYREL EAFAQFGSDLDQATQAKLNRGARTVEVLKQDLNKPLPVEKQVAILYALTKGYLDDIPV ADIRRFEEEYYMYLDQNHKDLLDGIAKTGNLPADEDFKAAIEGFKRTFAPSN*" /label="atpA CDS" gene complement(3268193..3269701) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /label="atpA gene" CDS complement(3269718..3270263) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit delta, component F1)" /protein_id="NP_391565.1" /db_xref="EnsemblGenomes-Gn:BSU36840" /db_xref="EnsemblGenomes-Tr:CAB15701" /db_xref="GOA:P37811" /db_xref="InterPro:IPR000711" /db_xref="InterPro:IPR020781" /db_xref="InterPro:IPR026015" /db_xref="SubtiList:BG10818" /db_xref="UniProtKB/Swiss-Prot:P37811" /translation="MSGSAVSKRYASALFDIANESAQLNQVEEELIVVKQVFQNEKAL NDVLNHPKVPAAKKKELIQNAFGSLSQSVLNTIFLLIDRHRAAIVPELTDEFIKLANV ARQTEDAIVYSVKPLTDAEMLPLSQVFAKKAGVASLRIRNEVQTDLIGGIKVRIGNRI YDGSVSGKLQRIERQLAGENR*" /label="atpH CDS" gene complement(3269718..3270263) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /label="atpH gene" CDS complement(3270260..3270772) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit b, component F0)" /protein_id="NP_391566.1" /db_xref="EnsemblGenomes-Gn:BSU36850" /db_xref="EnsemblGenomes-Tr:CAB15702" /db_xref="GOA:P37814" /db_xref="InterPro:IPR002146" /db_xref="InterPro:IPR005864" /db_xref="InterPro:IPR028987" /db_xref="SubtiList:BG10817" /db_xref="UniProtKB/Swiss-Prot:P37814" /translation="MSQLPLELGLSFNGGDILFQLLAMLILLALLKKYALGPLLNIMK QREDHIAGEITSAEEKNKEAQQLIEEQRVLLKEARQESQTLIENAKKLGEKQKEEIIQ AARAESERLKEAARTEIVKEKEQAVSALREQVASLSVMIASKVIEKELDEQAQEKLIQ DYLKEVGESR*" /label="atpF CDS" gene complement(3270260..3270772) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /label="atpF gene" S_feature complement(3270773..3270934) /Source="Nicolas_S_feature" /locus_tag="new_3786458_3786619_c" /HighExp="S2, Lbstat, Mal, M40t90, M0t90, G150, MG-0.1, G135, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1425" CDS complement(3270935..3271147) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit c, component F0)" /protein_id="NP_391567.1" /db_xref="EnsemblGenomes-Gn:BSU36860" /db_xref="EnsemblGenomes-Tr:CAB15703" /db_xref="GOA:P37815" /db_xref="InterPro:IPR000454" /db_xref="InterPro:IPR002379" /db_xref="InterPro:IPR005953" /db_xref="InterPro:IPR020537" /db_xref="InterPro:IPR035921" /db_xref="SubtiList:BG10816" /db_xref="UniProtKB/Swiss-Prot:P37815" /translation="MNLIAAAIAIGLGALGAGIGNGLIVSRTVEGIARQPEAGKELRT LMFMGIALVEALPIIAVVIAFLAFFG*" /label="atpE CDS" gene complement(3270935..3271147) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /label="atpE gene" CDS complement(3271193..3271927) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit a, component F0)" /protein_id="NP_391568.1" /db_xref="EnsemblGenomes-Gn:BSU36870" /db_xref="EnsemblGenomes-Tr:CAB15704" /db_xref="GOA:P37813" /db_xref="InterPro:IPR000568" /db_xref="InterPro:IPR023011" /db_xref="InterPro:IPR035908" /db_xref="SubtiList:BG10815" /db_xref="UniProtKB/Swiss-Prot:P37813" /translation="MNHGYRTIEFLGLTFNLTNILMITVASVIVLLIAILTTRTLSIR PGKAQNFMEWIVDFVRNIIGSTMDLKTGANFLALGVTLLMYIFVSNMLGLPFSITIGH ELWWKSPTADPAITLTLAVMVVALTHYYGVKMKGLKEYSKDYLRPVPFMLPMKIIEEF ANTLTLGLRLYGNIFAGEILLGLLAGLATSHYSQSVALGLVGTIGAILPMLAWQAFSL FIGAIQAFIFTMLTMVYMSHKISHDH*" /label="atpB CDS" gene complement(3271193..3271927) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /label="atpB gene" promotor_no_box 3271741..3271841 /Source="Nicolas_upshift_promotors" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3271801 /Source="Nicolas_upshifts" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3271935..3272318) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /function="16.1: Circulate" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12917488, 15849754, 16850406, 23123906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12917488, 15849754, 16850406, 23123906; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit i)" /protein_id="NP_391569.1" /db_xref="EnsemblGenomes-Gn:BSU36880" /db_xref="EnsemblGenomes-Tr:CAB15705" /db_xref="GOA:P37816" /db_xref="InterPro:IPR005598" /db_xref="SubtiList:BG10814" /db_xref="UniProtKB/Swiss-Prot:P37816" /translation="MDDPKLTFSRQRKYLLFILAVYVLGYGLTAYKTVFLGLILGTVF SLFNFLLLVRRMNAFDRAVEKGKSIRSLGSAARWCNAILAVAVAYKNPEYFHMASTVI GLMTIYPVIMIDSFIQLKRSSMEER*" /label="atpI CDS" gene complement(3271935..3272318) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /label="atpI gene" misc_feature complement(3272007..3272025) /Source="Nicolas_upshift_promotors" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3272009) /Source="Nicolas_upshifts" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" S_feature complement(3272319..3272589) /Source="Nicolas_S_feature" /locus_tag="new_3788004_3788274_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, UNK1, B60, G135, G180, G150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.96" /label="S1426" promotor_-35 3272551..3272560 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3272560 /Source="Nicolas_upshifts" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3272565..3272584) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" promotor_-10 3272574..3272593 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3272589) /Source="Nicolas_upshifts" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" S_feature complement(3272591..3272712) /Source="Nicolas_S_feature" /locus_tag="new_3788276_3788397_c" /HighExp="Etha, G180, H2O2, G135, Oxctl, G150, LBGexp, dia15, B36, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.96" /label="S1427" promotor_-35 complement(3272597..3272604) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3272741..3273370) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /EC_number="2.4.2.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7798145, 15689504, 15716449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 15689504, 15716449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil phosphoribosyltransferase" /protein_id="NP_391570.1" /db_xref="EnsemblGenomes-Gn:BSU36890" /db_xref="EnsemblGenomes-Tr:CAB15706" /db_xref="GOA:P39149" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005765" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR034332" /db_xref="SubtiList:BG10945" /db_xref="UniProtKB/Swiss-Prot:P39149" /translation="MGKVYVFDHPLIQHKLTYIRNENTGTKDFRELVDEVATLMAFEI TRDLPLEEVDINTPVQAAKSKVISGKKLGVVPILRAGLGMVDGILKLIPAAKVGHVGL YRDPETLKPVEYYVKLPSDVEEREFIVVDPMLATGGSAVEAIHSLKKRGAKNIRFMCL VAAPEGVEELQKHHSDVDIYIAALDEKLNEKGYIVPGLGDAGDRMFGTK*" /label="upp CDS" gene complement(3272741..3273370) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /label="upp gene" downshifts complement(3272757) /Source="Nicolas_upshifts" /id="D1907" /incds=0 /nref=180 /ntot=252 /MaxReadThrough="5.83241" /MaxDrop="5.91252" /score="1.39547358" /energy="-7.3" /TU="U2900,U2901" /idTUdmin="U2900" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3273414..3273433) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" upshifts complement(3273437) /Source="Nicolas_upshifts" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" promotor_-35 complement(3273448..3273455) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3273505..3274752) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /EC_number="2.1.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine hydroxymethyltransferase" /protein_id="NP_391571.1" /db_xref="EnsemblGenomes-Gn:BSU36900" /db_xref="EnsemblGenomes-Tr:CAB15707" /db_xref="GOA:P39148" /db_xref="InterPro:IPR001085" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR019798" /db_xref="SubtiList:BG10944" /db_xref="UniProtKB/Swiss-Prot:P39148" /translation="MKHLPAQDEQVFNAIKNERERQQTKIELIASENFVSEAVMEAQG SVLTNKYAEGYPGKRYYGGCEHVDVVEDIARDRAKEIFGAEHVNVQPHSGAQANMAVY FTILEQGDTVLGMNLSHGGHLTHGSPVNFSGVQYNFVEYGVDKETQYIDYDDVREKAL AHKPKLIVAGASAYPRTIDFKKFREIADEVGAYFMVDMAHIAGLVAAGLHPNPVPYAD FVTTTTHKTLRGPRGGMILCREEFGKKIDKSIFPGIQGGPLMHVIAAKAVSFGEVLQD DFKTYAQNVISNAKRLAEALTKEGIQLVSGGTDNHLILVDLRSLGLTGKVAEHVLDEI GITSNKNAIPYDPEKPFVTSGIRLGTAAVTSRGFDGDALEEVGAIIALALKNHEDEGK LEEARQRVAALTDKFPLYKELDY*" /label="glyA CDS" gene complement(3273505..3274752) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /label="glyA gene" downshifts complement(3273528) /Source="Nicolas_upshifts" /id="D1908" /incds=0 /nref=183 /ntot=229 /MaxReadThrough="5.99283" /MaxDrop="6.62881" /score="22.1245386" /energy="-15.8" /TU="U2901" /idTUdmin="U2902" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3274794..3274813) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3274811) /Source="Nicolas_upshifts" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3274813..3274897) /Source="Nicolas_S_feature" /locus_tag="new_3790498_3790582_c" /HighExp="dia5, C90, dia15, Diami, Lbtran, LPhT, M40t45, H2O2, BI, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1428" promotor_-35 complement(3274828..3274833) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3274942) /Source="Nicolas_upshifts" /id="D1909" /incds=0 /nref=3 /ntot=12 /MaxReadThrough="7.23859" /MaxDrop="5.0386" /score="-3.86767322" /energy="-4.3" /TU="U2902,U2903" /idTUdmin="U2904" /TUdmin=1137 /isTUend="FALSE" /label="downshifts" CDS complement(3274959..3275501) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391572.1" /db_xref="EnsemblGenomes-Gn:BSU36910" /db_xref="EnsemblGenomes-Tr:CAB15708" /db_xref="InterPro:IPR006340" /db_xref="InterPro:IPR028345" /db_xref="SubtiList:BG10943" /db_xref="UniProtKB/Swiss-Prot:P39157" /translation="MNELKQTWKTMLSEFQDQAELKQDQLFVLGCSTSEVAGSRIGTS GSVDIAESIYSGLAELREKTGIHLAFQCCEHLNRALVVEAETAKLFRLPTVSAVPVPK AGGAMASYAFKQMKSPVLVETIQADAGIDIGDTFIGMHLKPVAVPVRVSQNSLGSAHV TLARTRPKLIGGVRAVYECE*" /label="ywlG CDS" gene complement(3274959..3275501) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /label="ywlG gene" CDS complement(3275514..3275963) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /EC_number="5.3.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15755726, 15995210, 18640127, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 15995210, 18640127, 19446032; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose 5-phosphate epimerase (promiscuous)" /protein_id="NP_391573.1" /db_xref="EnsemblGenomes-Gn:BSU36920" /db_xref="EnsemblGenomes-Tr:CAB15709" /db_xref="GOA:P39156" /db_xref="InterPro:IPR003500" /db_xref="InterPro:IPR004785" /db_xref="InterPro:IPR036569" /db_xref="SubtiList:BG10942" /db_xref="UniProtKB/Swiss-Prot:P39156" /translation="MKVAIASDHGGVHIRNEIKELMDELQIEYIDMGCDCGSGSVDYP DYAFPVAEKVVSGEVDRGILICGTGIGMSISANKVKGIRCALAHDTFSAKATREHNDT NILAMGERVIGPGLAREIAKIWLTTEFTGGRHQTRIGKISDYEEKNL*" /label="rpiB CDS" gene complement(3275514..3275963) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /label="rpiB gene" S_feature complement(3275964..3276063) /Source="Nicolas_S_feature" /locus_tag="new_3791649_3791748_c" /HighExp="Diami, dia5, C90, dia15, LPhT, M40t45, LBGtran, Lbtran, T-0.40H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.68276199999999998" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1429" promotor_-10 complement(3276055..3276074) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-10" upshifts complement(3276063) /Source="Nicolas_upshifts" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="upshifts" promotor_-35 complement(3276088..3276095) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-35" CDS complement(3276120..3276572) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /EC_number="3.9.1.2" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210, 22517742, 24825175, 25610436, 27524296" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210, 22517742, 24825175, 25610436, 27524296; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-arginine(tyrosine moonlighting) phosphatase (oxidative stress)" /protein_id="NP_391574.1" /db_xref="EnsemblGenomes-Gn:BSU36930" /db_xref="EnsemblGenomes-Tr:CAB15710" /db_xref="GOA:P39155" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:1ZGG" /db_xref="PDB:4ETI" /db_xref="PDB:4ETN" /db_xref="PDB:4KK3" /db_xref="PDB:4KK4" /db_xref="SubtiList:BG10941" /db_xref="UniProtKB/Swiss-Prot:P39155" /translation="MDIIFVCTGNTCRSPMAEALFKSIAEREGLNVNVRSAGVFASPN GKATPHAVEALFEKHIALNHVSSPLTEELMESADLVLAMTHQHKQIIASQFGRYRDKV FTLKEYVTGSHGDVLDPFGGSIDIYKQTRDELEELLRQLAKQLKKDRR*" /label="prpB CDS" gene complement(3276120..3276572) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /label="prpB gene" promotor_-10 complement(3276589..3276608) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-10" upshifts complement(3276607) /Source="Nicolas_upshifts" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="upshifts" promotor_-35 complement(3276623..3276626) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-35" CDS complement(3276648..3277205) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 25774656, 25794618, 26076491; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="manganese efflux pump" /protein_id="NP_391575.1" /db_xref="EnsemblGenomes-Gn:BSU36940" /db_xref="EnsemblGenomes-Tr:CAB15711" /db_xref="GOA:P39154" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR022929" /db_xref="SubtiList:BG10940" /db_xref="UniProtKB/Swiss-Prot:P39154" /translation="MSDLFIGELITLSIMAFALGMDAFSVGLGMGMVKLRKKQIFYIG FIIGLFHVIMPLAGMAAGNMLSGLLGVLAVYIGGALLFVLGVQMLMASFKQSEERFMS PAGPGLLLFAIGVSLDSFSVGLSLGIYGSHPLLTITLFGLFSMMLTWLGLLVGKQVQS WLGTYSEALGGIILIVFGLKLLLPI*" /label="mntP CDS" gene complement(3276648..3277205) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /label="mntP gene" promotor_-10 complement(3277232..3277250) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-10" upshifts complement(3277245) /Source="Nicolas_upshifts" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="upshifts" promotor_-35 complement(3277266..3277271) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-35" CDS complement(3277284..3278324) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; threonine-dependent ADP-forming ATPase" /protein_id="NP_391576.1" /db_xref="EnsemblGenomes-Gn:BSU36950" /db_xref="EnsemblGenomes-Tr:CAB15712" /db_xref="GOA:P39153" /db_xref="InterPro:IPR005145" /db_xref="InterPro:IPR006070" /db_xref="InterPro:IPR010923" /db_xref="InterPro:IPR017945" /db_xref="SubtiList:BG10939" /db_xref="UniProtKB/Swiss-Prot:P39153" /translation="MKTKRWFVDVTDELSTNDPQIAQAAALLRENEVVAFPTETVYGL GANAKNTDAVKKIYEAKGRPSDNPLIVHIADISQLEDLTGPAPEKAKTLMKRFWPGAL TLILPCKPDALSPRVTAGLETVAIRMPDHPLALALIRESGLPIAAPSANLSGKPSPTK AEHVAHDLDGRIAGIVDGGPTGIGVESTVLSCADDIPVLLRPGGITKEQIEAVIGPIH VDKGLSDQNEKPISPGMKYTHYAPTAPLAICEGSPERIQHLIQEYQQGGRRVGVLTTE EKAGVYSADYVKSCGRRAQLETVAAGLYDALRSFDENKVDFIIAESFPDTGVGLAIMN RLMKAAGGRVIR*" /label="tsaC CDS" gene complement(3277284..3278324) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /label="tsaC gene" downshifts complement(3277289) /Source="Nicolas_upshifts" /id="D1910" /incds=0 /nref=4 /ntot=166 /MaxReadThrough="2.08557" /MaxDrop="2.98653" /score="-6.24994287" /energy="-9.8" /TU="NA" /idTUdmin="U2905" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3278325..3278389) /Source="Nicolas_S_feature" /locus_tag="new_3794010_3794074_c" /HighExp="dia15, Diami, C90, LBGstat, Heat, LBGtran, dia5, LBGexp, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1430" promotor_-10 complement(3278379..3278398) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3278389) /Source="Nicolas_upshifts" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3278391..3278480) /Source="Nicolas_S_feature" /locus_tag="new_3794076_3794165_c" /HighExp="S3, M9-stat, Etha, LoTm, T5.0H, S7, S8, S4, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1431" promotor_-35 complement(3278414..3278418) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3278481..3278924) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391577.1" /db_xref="EnsemblGenomes-Gn:BSU36960" /db_xref="EnsemblGenomes-Tr:CAB15713" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10938" /db_xref="UniProtKB/Swiss-Prot:P39152" /translation="MFYQLRVAREKDGDVLEAFLKQAKTSYEGVKEGFTQFLMLEDSE KNIAGCLGIEKISCDQGLLRSLVISDKLHQGHIVTLFQSMEVLCEKHQIKTVYLVANQ HSSADFLTAMGFERAESVPEELFSSDHFCESRQTEGAVLMKKASG*" /label="ywlB CDS" gene complement(3278481..3278924) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /label="ywlB gene" CDS complement(3278991..3279665) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15044948, 16824103, 18378688, 20802044, 22111992" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15044948, 16824103, 18378688, 20802044, 22111992; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator signal of pro-sigma(E) spoIIGA endopeptidase (stage II sporulation)" /protein_id="NP_391578.1" /db_xref="EnsemblGenomes-Gn:BSU36970" /db_xref="EnsemblGenomes-Tr:CAB15714" /db_xref="GOA:P39151" /db_xref="InterPro:IPR014202" /db_xref="SubtiList:BG10937" /db_xref="UniProtKB/Swiss-Prot:P39151" /translation="MKKTVIICIYIFLLLSGALVGLAKEETAQKSENQPVVIPDQAIR LRILANSDSDQDQQLKRHIRDAVNKEITTWVKDITSIEEARRVIRSKLPEIKAIAKET MEKEGANQSISVDFDKISFPTKLYGNMVYPAGEYEAILITLGNGDGANWWCVLFPPLC FLDFSNGEAVKEQEDKEASKKQTEKVLEDVTAKAEKAKKEENEEKEDGTEVKFFLVEW ISDLFS*" /label="spoIIR CDS" gene complement(3278991..3279665) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /label="spoIIR gene" promotor_-10 complement(3279427..3279445) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3279434) /Source="Nicolas_upshifts" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3279460..3279466) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3279697..3279714) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3279698) /Source="Nicolas_upshifts" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3279730..3279735) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3279771 /Source="Nicolas_upshifts" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3279775..3279794 /Source="Nicolas_upshift_promotors" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3279806..3280168 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391579.1" /db_xref="EnsemblGenomes-Gn:BSU36980" /db_xref="EnsemblGenomes-Tr:CAB15715" /db_xref="GOA:P39150" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG10936" /db_xref="UniProtKB/Swiss-Prot:P39150" /translation="MKYNYTVLLSAFTMSVLYSVIYIHSFIIAALITMAFYFLFPYLI FALPLQIMMNKKPKRFSPLYLLYYLAAAFIANAIIFGMLQPSGQSLFQNTAFYLFAVL TALIYWIWDSVLLQKKEA*" /label="ywlA CDS" gene 3279806..3280168 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /label="ywlA gene" downshifts complement(3280181) /Source="Nicolas_upshifts" /id="D1911" /incds=0 /nref=27 /ntot=242 /MaxReadThrough="2.64328" /MaxDrop="5.72616" /score="26.8558862" /energy="-11.3" /TU="U2910" /idTUdmin="U2909" /TUdmin=12 /isTUend="TRUE" /label="downshifts" CDS complement(3280185..3280472) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391580.1" /db_xref="EnsemblGenomes-Gn:BSU36990" /db_xref="EnsemblGenomes-Tr:CAB15716" /db_xref="GOA:P45874" /db_xref="InterPro:IPR035167" /db_xref="SubtiList:BG11317" /db_xref="UniProtKB/Swiss-Prot:P45874" /translation="MKKALTAGILLIAIESMIGTIFPQALSYEAIFGVASLVLVGLAI ITSGLAVSGSDQRANYHSETKEGRTSRMKMAAAFFVAAIPSILCYLLTILF*" /label="ywkF CDS" gene complement(3280185..3280472) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /label="ywkF gene" S_feature complement(3280473..3280531) /Source="Nicolas_S_feature" /locus_tag="new_3796158_3796216_c" /HighExp="S6, S8, S7, BT, G135, G180, Paraq, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1432" promotor_-10 complement(3280529..3280548) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3280532..3281398) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /EC_number="2.1.1.297" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 16364916, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine methylase of release factor 1 (and perhaps others) at a GGQ site" /protein_id="NP_391581.1" /db_xref="EnsemblGenomes-Gn:BSU37000" /db_xref="EnsemblGenomes-Tr:CAB15717" /db_xref="GOA:P45873" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004556" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR019874" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11316" /db_xref="UniProtKB/Swiss-Prot:P45873" /translation="MKTIFEALKWASSYLTEAGREENAAELLLLYDTGMERSKLLASL QEPIGEDELYRFKRHVEMHKEGVPVQYIIGKEFFYGREFMVNDDVLIPRPETEEVVFH LLEKYRSVFSEDGKLEVVDVGTGSGAIAVTLALENQSFSVSAVDISKEALQVASANAE KLGANVRFYQGDLLEPFIKAGKKADIIVSNPPYISEEEMADLSEIVRFHEPLHALTDG GDGLKFYKRFMEDIPLVMKDKVFVVFEIGWKQGAAVKDLILKAFKGAEVEVLKDINGK DRTICALIHKNK*" /label="prmC CDS" gene complement(3280532..3281398) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /label="prmC gene" upshifts complement(3280545) /Source="Nicolas_upshifts" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3280561..3280570) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3281400..3282470) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /experiment="publication(s) with functional evidences, PMID:2186375, 1408743, 10446248, 12237459, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2186375, 1408743, 10446248, 12237459, 12682299; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 1" /protein_id="NP_391582.1" /db_xref="EnsemblGenomes-Gn:BSU37010" /db_xref="EnsemblGenomes-Tr:CAB15718" /db_xref="GOA:P45872" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004373" /db_xref="InterPro:IPR005139" /db_xref="SubtiList:BG11244" /db_xref="UniProtKB/Swiss-Prot:P45872" /translation="MLDRLKSIEERYEKLNELLSDPEVVNDPKKLREYSKEQSDIQET VDVYRQYRDASEQLADAKAMLEEKLDAEMRDMVKEEISELQKETETLSERLKVLLIPK DPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQGWKTEVMEANVTGTGGYKE IIFMITGSGAYSKLKYENGAHRVQRVPETESGGRIHTSTATVACLPEAEEVEVDIHEK DIRVDTFASSGPGGQSVNTTMSAVRLTHLPTGVVVSCQDEKSQIKNKEKAMKVLRARI YDKFQQEAQAEYDQTRKSAVGSGDRSERIRTYNFPQNRVTDHRIGLTIQKLDQILEGK LDEVVEALIVEDQASKLQQSEG*" /label="prfA CDS" gene complement(3281400..3282470) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /label="prfA gene" downshifts complement(3281403) /Source="Nicolas_upshifts" /id="D1912" /incds=0 /nref=23 /ntot=212 /MaxReadThrough="5.17118" /MaxDrop="3.44681" /score="-9.55295942" /energy="-10.5" /TU="U2910" /idTUdmin="U2912" /TUdmin=1122 /isTUend="FALSE" /label="downshifts" downshifts 3282471 /Source="Nicolas_upshifts" /id="D1913" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.13519" /MaxDrop="4.28706" /score="36.3991981" /energy="-10.4" /TU="NA" /idTUdmin="U2911" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3282498..3282517) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3282522) /Source="Nicolas_upshifts" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3282524..3282635) /Source="Nicolas_S_feature" /locus_tag="new_3798209_3798320_c" /HighExp="S6, S8, S7, BT, S5, Etha, B36, C30, S4, GM 25" /AntisenseName="ywkD" /AntisenseCor="-0.43140174721346802" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.927" /TUlongSig="NA" /TUlongPSig="NA" /label="S1433" promotor_-35 complement(3282531..3282537) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3282567..3282586 /Source="Nicolas_upshift_promotors" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3282581 /Source="Nicolas_upshifts" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="upshifts" CDS 3282596..3282982 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391583.1" /db_xref="EnsemblGenomes-Gn:BSU37020" /db_xref="EnsemblGenomes-Tr:CAB15719" /db_xref="GOA:P45871" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11315" /db_xref="UniProtKB/Swiss-Prot:P45871" /translation="MLLKSIHHIAIICSDYEKSKAFYVHKLGFQVIQETYREERGSYK LDLSLNGSYVIELFSFPDPPERQTRPEAAGLRHLAFTVGSLDKAVQELHEKGIETEPI RTDPLTGKRFTFFFDPDQLPLELYEQ*" /label="ywkD CDS" gene 3282596..3282982 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /label="ywkD gene" promotor_-10 complement(3282617..3282635) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-10" upshifts complement(3282635) /Source="Nicolas_upshifts" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="upshifts" promotor_-35 complement(3282649..3282656) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-35" promotor_-35 3283050..3283058 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3283069..3283087 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3283070 /Source="Nicolas_upshifts" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="upshifts" CDS 3283104..3283658 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15780934, 17139259, 19478798, 22720735, 27059541, 27085804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15780934, 17139259, 19478798, 22720735, 27059541, 27085804; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome-pole-anchoring protein RacA" /protein_id="NP_391584.1" /db_xref="EnsemblGenomes-Gn:BSU37030" /db_xref="EnsemblGenomes-Tr:CAB15720" /db_xref="GOA:P45870" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR023522" /db_xref="PDB:5I41" /db_xref="PDB:5I44" /db_xref="SubtiList:BG11314" /db_xref="UniProtKB/Swiss-Prot:P45870" /translation="MNTNMVASELGVSAKTVQRWVKQLNLPAERNELGHYSFTAEDVK VLKSVQKQISEGTAIQDIHLPKSAKKRTGFLVQKTSSDTERRIEQLEQKLDTLLQQRQ DESELMARMSELERQLKQKADEGVSYQLLQHRREIDDILADLQSLTSQMKEFTAHSIP ETAAASEKTKTRKKPLLSLFKFQT*" /label="racA CDS" gene 3283104..3283658 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /label="racA gene" misc_feature 3283588..3283592 /Source="Nicolas_upshift_promotors" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3283593 /Source="Nicolas_upshifts" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3283637 /Source="Nicolas_upshifts" /id="D1914" /incds=0 /nref=213 /ntot=274 /MaxReadThrough="0.82868" /MaxDrop="8.28021" /score="36.3991981" /energy="-10.4" /TU="U2913" /idTUdmin="U2914" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3283692..3284651) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12949160, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391585.1" /db_xref="EnsemblGenomes-Gn:BSU37040" /db_xref="EnsemblGenomes-Tr:CAB15721" /db_xref="GOA:P45869" /db_xref="InterPro:IPR004776" /db_xref="InterPro:IPR014024" /db_xref="SubtiList:BG11313" /db_xref="UniProtKB/Swiss-Prot:P45869" /translation="MSILDILILLAPIFFVIVLGWFAGHFGSYDAKSAKGVSTLVTKY ALPAHFIAGILTTSRSEFLSQVPLMISLIIGIVGFYIIILLVCRFIFKYDLTNSSVFS LNSAQPTFAFMGIPVLGSLFGANEVAIPIAVTGIVVNAILDPLAIIIATVGESSKKNE ESGDSFWKMTGKSILHGLCEPLAAAPLISMILVLVFNFTLPELGVKMLDQLGSTTSGV ALFAVGVTVGIRKIKLSMPAIGIALLKVAVQPALMFLIALAIGLPADQTTKAILLVAF PGSAVAAMIATRFEKQEEETATAFVVSAILSLISLPIIIALTA*" /label="ywkB CDS" gene complement(3283692..3284651) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /label="ywkB gene" downshifts complement(3283714) /Source="Nicolas_upshifts" /id="D1915" /incds=0 /nref=36 /ntot=74 /MaxReadThrough="2.86006" /MaxDrop="4.78642" /score="20.048754" /energy="-10.4" /TU="U2916" /idTUdmin="U2917" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3284689..3284707) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3284703) /Source="Nicolas_upshifts" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3284722..3284728) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3284733..3286481) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12949160, 16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949160, 16788182, 20933603, 22740702, 23136871, 24325460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_391586.1" /db_xref="EnsemblGenomes-Gn:BSU37050" /db_xref="EnsemblGenomes-Tr:CAB15722" /db_xref="GOA:P45868" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11312" /db_xref="UniProtKB/Swiss-Prot:P45868" /translation="MGYYLTWLTISRKKEICLNNIKKTKEGHLETTLRGKEVLSIPTL NKGVAFSLEERQELGLEGLLPPTVLSLDQQAQRAYEQFQAQPDRLRQNVYLSDLANRN EVLFYKLLKNHLREMLPVVYTPTVGEAIQEYSHEYRRPQGIYLSIDNIDGIEKAFENL HATAGDIDLIVATDSESILGIGDWGVGGINIAIGKLAVYTAAAGIDPSRVIPVVLDVG TNNEKLLNDPLYIGNKHERVQGERYEAFIDAYVKAALKFFPKALLHWEDLGNKNARNI MKKYNHEILTFNDDIQGTGAITLAGVLAAMKKTGASIKDQRVVIFGAGSAGIGIADQI RDTMVLAGLSEEEANKRFYTLDYRGLLTEDIEGILDFQKPYLRNADEVKDWKRDEKGQ IPFDEVVRQAKPTILIGTSGVSGAFTEEIVKEMASHVDRPVIMPMSNPTHLAEAVPED LFKWTDGKVLIATGSPFDNVEYNGVSYEIGQSNNAFAFPGLGLGSIVAEARIITPAMF AATADAIAEMVDLETPGAGLLPSIDKLQEVSIQVAIAVAEAAIKDGVANRQPEDVKQA VLDAMWTPEYKKVIAK*" /label="maeA CDS" gene complement(3284733..3286481) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /label="maeA gene" promotor_-10 complement(3285207..3285225) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3285215) /Source="Nicolas_upshifts" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3285240..3285246) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3286482..3286572) /Source="Nicolas_S_feature" /locus_tag="new_3802167_3802257_c" /HighExp="GM 25, GM 15, GM 60, GM 90, GM 120, MG-0.2, MG 15, GM 45, MG-0.1, GM 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1434" promotor_-10 complement(3286556..3286575) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3286572) /Source="Nicolas_upshifts" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3286589..3286596) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3286715) /Source="Nicolas_upshifts" /id="D1916" /incds=0 /nref=11 /ntot=126 /MaxReadThrough="2.81368" /MaxDrop="3.39095" /score="20.3711149" /energy="-7.5" /TU="NA" /idTUdmin="U2918" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(3286720..3287307) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /EC_number="2.7.1.21" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2423635, 17132103; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidine kinase" /protein_id="NP_391587.1" /db_xref="EnsemblGenomes-Gn:BSU37060" /db_xref="EnsemblGenomes-Tr:CAB15723" /db_xref="GOA:Q03221" /db_xref="InterPro:IPR001267" /db_xref="InterPro:IPR020633" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10419" /db_xref="UniProtKB/Swiss-Prot:Q03221" /translation="MYIMKQSGWLELICGSMFSGKSEELIRRVKRATYAKQEVRVFKP VIDNRYSEAAVVSHNGTSMTSYAISSAADIWDHISESTDVVAVDEVQFFDQEIVEVLS SLADKGYRVIAAGLDMDFRGEPFGVVPNIMAIAESVTKLQAVCSVCGSPASRTQRLID GKPASYDDPVILVGAAESYEARCRHHHEVPGKSKK*" /label="tdk CDS" gene complement(3286720..3287307) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /label="tdk gene" CDS complement(3287396..3287596) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_391588.1" /db_xref="EnsemblGenomes-Gn:BSU37070" /db_xref="EnsemblGenomes-Tr:CAB15724" /db_xref="GOA:Q03223" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027491" /db_xref="InterPro:IPR034704" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10417" /db_xref="UniProtKB/Swiss-Prot:Q03223" /translation="MKAGIHPNFKKATVKCACGNEFETGSVKEEVRVEICSECHPFYT GRQKFASADGRVDRFNKKYGLK*" /label="rpmEA CDS" gene complement(3287396..3287596) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /label="rpmEA gene" downshifts complement(3287409) /Source="Nicolas_upshifts" /id="D1917" /incds=0 /nref=268 /ntot=279 /MaxReadThrough="5.35148" /MaxDrop="6.82076" /score="15.63162" /energy="-10.3" /TU="U2918,U2919" /idTUdmin="U2921" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3287597..3287674) /Source="Nicolas_S_feature" /locus_tag="new_3803282_3803359_c" /HighExp="HPh, LPh, LPhT, GM 45, Paraq, MG 45, MG 60, aero, LBGexp, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1435" promotor_-10 complement(3287670..3287689) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3287674) /Source="Nicolas_upshifts" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3287703..3287710) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3287715..3288998) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10027981, 16014871, 18852477, 28520932, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10027981, 16014871, 18852477, 28520932, 28723971; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcriptional terminator Rho" /protein_id="NP_391589.2" /db_xref="EnsemblGenomes-Gn:BSU37080" /db_xref="EnsemblGenomes-Tr:CAB15725" /db_xref="GOA:Q03222" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004665" /db_xref="InterPro:IPR011112" /db_xref="InterPro:IPR011113" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036269" /db_xref="SubtiList:BG10416" /db_xref="UniProtKB/Swiss-Prot:Q03222" /translation="MKDVSISSLENMKLKELYELARHYKISYYSKLTKKELIFAILKA NAEQEDLLFMEGVLEIIQSEGFGFLRPINYSPSSEDIYISASQIRRFDLRNGDKVSGK VRPPKENERYYGLLHVEAVNGDDPESAKERVHFPALTPLYPDRQMVLETKPNFLSTRI MDMMAPVGFGQRGLIVAPPKAGKTMLLKEIANSITANQPEAELIVLLIDERPEEVTDI ERSVAGDVVSSTFDEVPENHIKVAELVLERAMRLVEHKKDVIILMDSITRLARAYNLV IPPSGRTLSGGIDPAAFHRPKRFFGAARNIEEGGSLTILATALVDTGSRMDDVIYEEF KGTGNMELHLDRSLAERRIFPAIDIRRSGTRKEELLVPKEHLDRLWSIRKTMSDSPDF AEKFMRKMKKTKTNQEFFDILNQEWKQANLSSARR*" /label="rho CDS" gene complement(3287715..3288998) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /label="rho gene" S_feature complement(3288999..3289301) /Source="Nicolas_S_feature" /locus_tag="new_3804684_3804986_c" /HighExp="H2O2, Cold, G135, HPh, G180, G150, LBGstat, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1436" CDS complement(3289029..3289190) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 20525796" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514010.1" /db_xref="EnsemblGenomes-Gn:BSU37089" /db_xref="EnsemblGenomes-Tr:CCQ48606" /db_xref="UniProtKB/TrEMBL:L8EA05" /translation="MFLSSLPSKLIKTILLTKAPIMGGSVTDRSSFMLKKECALADVV QKQQMTCSE*" /label="hypothetical protein CDS" gene complement(3289029..3289190) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /label="gene" promotor_-10 complement(3289281..3289300) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3289301) /Source="Nicolas_upshifts" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3289316..3289320) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3289405..3290370) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /EC_number="3.1.3.11" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose 1,6-bisphosphatase class II" /protein_id="NP_391590.1" /db_xref="EnsemblGenomes-Gn:BSU37090" /db_xref="EnsemblGenomes-Tr:CAB15726" /db_xref="GOA:Q03224" /db_xref="InterPro:IPR004464" /db_xref="SubtiList:BG10415" /db_xref="UniProtKB/Swiss-Prot:Q03224" /translation="MERSLSMELVRVTEAAALASARWMGRGKKDEADEAATSAMRDVF DTVPMKGTVVIGEGEMDEAPMLYIGEKLGNGYGPRVDVAVDPLEGTNILASGGWNALT VIAVADHGTLLNAPDMYMQKIAVGPEAVGCIDIEAPVIDNLKAVAKAKNKDVEDVVAT ILNRERHAKIISELREAGARIKLINDGDVAGAINTAFDHTGVDILFGSGGAPEGVLSA VALKALGGEIIGKLLPQSEEEITRCHKMGLDLSKVLRMEDLVKGDDAIFAATGVTDGE LLKGVQFKGSVGTTESLVIRAKSGTVRFVDGRHSLKKKPNLVIRP*" /label="glpX CDS" gene complement(3289405..3290370) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /label="glpX gene" downshifts complement(3289411) /Source="Nicolas_upshifts" /id="D1918" /incds=0 /nref=56 /ntot=196 /MaxReadThrough="5.42698" /MaxDrop="5.21817" /score="-2.15106481" /energy="-10.2" /TU="U2921,U2922" /idTUdmin="U2922" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 3289987..3289996 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3290009..3290028 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3290017 /Source="Nicolas_upshifts" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3290401..3291690) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /EC_number="2.5.1.7" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14763982, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14763982, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391591.2" /db_xref="EnsemblGenomes-Gn:BSU37100" /db_xref="EnsemblGenomes-Tr:CAB15727" /db_xref="GOA:P19670" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10414" /db_xref="UniProtKB/Swiss-Prot:P19670" /translation="MEKLNIAGGDSLNGTVHISGAKNSAVALIPATILANSEVTIEGL PEISDIETLRDLLKEIGGNVHFENGEMVVDPTSMISMPLPNGKVKKLRASYYLMGAML GRFKQAVIGLPGGCHLGPRPIDQHIKGFEALGAEVTNEQGAIYLRAERLRGARIYLDV VSVGATINIMLAAVLAEGKTIIENAAKEPEIIDVATLLTSMGAKIKGAGTNVIRIDGV KELHGCKHTIIPDRIEAGTFMIAGAAMGKEVIIDNVIPTHLESLTAKLREMGYHIETS DDQLLIVGGQKNLKPVDVKTLVYPGFPTDLQQPMTALLTRAKGTSVVTDTIYSARFKH IDELRRMGANMKVEGRSAIITGPVELQGAKVKASDLRAGACLVVAGLMADGVTEITGL EHIDRGYSSLEKKLEGLGATIWRERMTDEEIEQLQNS*" /label="murAB CDS" gene complement(3290401..3291690) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /label="murAB gene" S_feature complement(3291691..3292050) /Source="Nicolas_S_feature" /locus_tag="new_3807376_3807735_c" /HighExp="dia5, Fru, UNK1, Glucon, HiOs, T-5.40H, nit, SMM, MG 120, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16076699999999999" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1437" CDS complement(3292069..3292707) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /EC_number="2.2.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 12469342, 22212631, 23468065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 12469342, 22212631, 23468065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transaldolase" /protein_id="NP_391592.3" /db_xref="EnsemblGenomes-Gn:BSU37110" /db_xref="EnsemblGenomes-Tr:CAB15728" /db_xref="GOA:P19669" /db_xref="InterPro:IPR001585" /db_xref="InterPro:IPR004731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018225" /db_xref="InterPro:IPR022999" /db_xref="InterPro:IPR033919" /db_xref="PDB:3R8R" /db_xref="SubtiList:BG10413" /db_xref="UniProtKB/Swiss-Prot:P19669" /translation="MLFFVDTANIDEIREANELGILAGVTTNPSLVAKEANVSFHDRL REITDVVKGSVSAEVISLKAEEMIEEGKELAKIAPNITVKIPMTSDGLKAVRALTDLG IKTNVTLIFNANQALLAARAGATYVSPFLGRLDDIGHNGLDLISEVKQIFDIHGLDTQ IIAASIRHPQHVTEAALRGAHIGTMPLKVIHALTKHPLTDKGIEQFLADWNK*" /label="tal CDS" gene complement(3292069..3292707) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /label="tal gene" downshifts complement(3292095) /Source="Nicolas_upshifts" /id="D1919" /incds=0 /nref=6 /ntot=65 /MaxReadThrough="6.97243" /MaxDrop="4.038" /score="-6.93331064" /energy="-18.4" /TU="U2921,U2922" /idTUdmin="U2926" /TUdmin=1716 /isTUend="FALSE" /label="downshifts" S_feature complement(3292708..3292826) /Source="Nicolas_S_feature" /locus_tag="new_3808393_3808511_c" /HighExp="dia5, LBGtran, M40t45, Lbtran, Mt0, M40t90, M0t45, Lbstat, Lbexp, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1438" CDS complement(3292827..3293684) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /EC_number="4.1.2.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphate aldolase" /protein_id="NP_391593.1" /db_xref="EnsemblGenomes-Gn:BSU37120" /db_xref="EnsemblGenomes-Tr:CAB15729" /db_xref="GOA:P13243" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10412" /db_xref="UniProtKB/Swiss-Prot:P13243" /translation="MPLVSMTEMLNTAKEKGYAVGQFNLNNLEFTQAILQAAEEEKSP VILGVSEGAGRYMGGFKTVVAMVKALMEEYKVTVPVAIHLDHGSSFESCAKAIHAGFT SVMIDASHHPFEENVATTAKVVELAHFHGVSVEAELGTVGGQEDDVIAEGVIYADPKE CQELVERTGIDCLAPALGSVHGPYKGEPNLGFKEMEEIGKSTGLPLVLHGGTGIPTAD IKKSISLGTAKINVNTENQISSAKAVRETLAAKPDEYDPRKYLGPAREAIKETVIGKM REFGSSNQA*" /label="fbaA CDS" gene complement(3292827..3293684) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /label="fbaA gene" S_feature complement(3293685..3293811) /Source="Nicolas_S_feature" /locus_tag="new_3809370_3809496_c" /HighExp="C90, Lbtran, LBGtran, dia5, LBGexp, aero, M0t90, Glu, Lbexp, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1439" promotor_-10 complement(3293793..3293812) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-10" upshifts complement(3293811) /Source="Nicolas_upshifts" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="upshifts" promotor_-35 complement(3293826..3293833) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-35" CDS complement(3293865..3294239) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator of sporulation initiation" /protein_id="NP_391594.1" /db_xref="EnsemblGenomes-Gn:BSU37130" /db_xref="EnsemblGenomes-Tr:CAB15730" /db_xref="GOA:P06628" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="PDB:1F51" /db_xref="PDB:1FSP" /db_xref="PDB:1NAT" /db_xref="PDB:1PEY" /db_xref="PDB:1PUX" /db_xref="PDB:1SRR" /db_xref="PDB:2FSP" /db_xref="PDB:2FTK" /db_xref="PDB:2JVI" /db_xref="PDB:2JVJ" /db_xref="PDB:2JVK" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG10411" /db_xref="UniProtKB/Swiss-Prot:P06628" /translation="MMNEKILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVT KERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTAYGELDMIQESKELGALTHF AKPFDIDEIRDAVKKYLPLKSN*" /label="spo0F CDS" gene complement(3293865..3294239) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /label="spo0F gene" promotor_-10 complement(3294279..3294297) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3294293) /Source="Nicolas_upshifts" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="upshifts" S_feature complement(3294295..3294934) /Source="Nicolas_S_feature" /locus_tag="new_3809980_3810619_c" /HighExp="dia15, Diami, dia5, G135, Etha, G150, G180, Salt, H2O2, Paraq" /AntisenseName="ywjG" /AntisenseCor="0.58536525532649697" /AntisenseRegPval="-25.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1440" promotor_-35 3294296..3294299 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3294308..3294316) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" promotor_-10 3294315..3294334 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3294328 /Source="Nicolas_upshifts" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3294342..3294347 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3294363..3294382 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3294373 /Source="Nicolas_upshifts" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="upshifts" CDS 3294405..3294926 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391595.1" /db_xref="EnsemblGenomes-Gn:BSU37140" /db_xref="EnsemblGenomes-Tr:CAB15731" /db_xref="InterPro:IPR019676" /db_xref="SubtiList:BG11053" /db_xref="UniProtKB/Swiss-Prot:P06629" /translation="MLKIFTTQLTGIFSRIQDKESDAIEDGARLLAQAVISGHSIYLY GANELQGVFYEATESKEPFPSVKAFPENAEEVTESDRVLMFCSGTGTAEEQELAKELY EKGAGVVCVSPAAKDSAGIEQYCDVHIDSKLKMPLVPDEDGTRYGFPSLMTALYVYHA LSFTLKEILQEYA*" /label="ywjG CDS" gene 3294405..3294926 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /label="ywjG gene" promotor_-35 3294869..3294872 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3294887..3294906 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3294901 /Source="Nicolas_upshifts" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3294924..3294943) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3294934) /Source="Nicolas_upshifts" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="upshifts" downshifts 3294945 /Source="Nicolas_upshifts" /id="D1920" /incds=0 /nref=191 /ntot=242 /MaxReadThrough="1.98527" /MaxDrop="5.8354" /score="11.5531593" /energy="-11.9" /TU="NA" /idTUdmin="U2923" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3294958..3294965) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" CDS complement(3295008..3296615) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /EC_number="6.3.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11544212, 15252202, 17158658, 17302819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544212, 15252202, 17158658, 17302819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CTP synthetase" /protein_id="NP_391596.1" /db_xref="EnsemblGenomes-Gn:BSU37150" /db_xref="EnsemblGenomes-Tr:CAB15743" /db_xref="GOA:P13242" /db_xref="InterPro:IPR004468" /db_xref="InterPro:IPR017456" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033828" /db_xref="SubtiList:BG10410" /db_xref="UniProtKB/Swiss-Prot:P13242" /translation="MTKYIFVTGGVVSSLGKGIVAASLGRLLKNRGLNVTIQKFDPYI NVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKFSNVTTGKIYSTVLKKE RRGDYLGGTVQVIPHITNELKDRVYRAGKETNADVVITEIGGTVGDIESLPFLEAIRQ MKSDIGRENVMYIHCTLVPYIKAAGELKTKPTQHSVKELRSLGIQPNIIVVRTEMPIS QDMKDKIALFCDIDTKAVIECEDADNLYSIPLELQKQGLDKLVCEHMKLACKEAEMSE WKELVNKVSNLSQTITIGLVGKYVELPDAYISVVESLRHAGYAFDTDVKVKWINAEEV TENNIAELTSGTDGIIVPGGFGDRGVEGKIVATKYARENNIPFLGICLGMQVASIEYA RNVLGLKGAHSAEIDPSTQYPIIDLLPEQKDVEDLGGTLRLGLYPCKLEEGTKAFEVY QDEVVYERHRHRYEFNNEFRQQMEEQGFVFSGTSPDGRLVEIIELKDHPWFVASQFHP EFKSRPTRPQPLFKGFIGASVEAANQK*" /label="pyrG CDS" gene complement(3295008..3296615) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /label="pyrG gene" downshifts complement(3295021) /Source="Nicolas_upshifts" /id="D1921" /incds=0 /nref=222 /ntot=259 /MaxReadThrough="2.2929" /MaxDrop="8.17874" /score="18.9699606" /energy="-12.1" /TU="NA" /idTUdmin="U2927" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3296616..3296803) /Source="Nicolas_S_feature" /locus_tag="new_3812301_3812488_c" /HighExp="LBGexp, Lbexp, dia0, G150, G135, G180, Paraq, Oxctl, dia15, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1441" promotor_-10 complement(3296791..3296810) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3296803) /Source="Nicolas_upshifts" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3296825..3296832) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3296857..3297378) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase (delta subunit) and transcriptional repressor" /protein_id="NP_391597.1" /db_xref="EnsemblGenomes-Gn:BSU37160" /db_xref="EnsemblGenomes-Tr:CAB15744" /db_xref="GOA:P12464" /db_xref="InterPro:IPR007759" /db_xref="InterPro:IPR029757" /db_xref="PDB:2KRC" /db_xref="PDB:2M4K" /db_xref="PDB:4NC7" /db_xref="PDB:4NC8" /db_xref="SubtiList:BG10409" /db_xref="UniProtKB/Swiss-Prot:P12464" /translation="MGIKQYSQEELKEMALVEIAHELFEEHKKPVPFQELLNEIASLL GVKKEELGDRIAQFYTDLNIDGRFLALSDQTWGLRSWYPYDQLDEETQPTVKAKKKKA KKAVEEDLDLDEFEEIDEDDLDLDEVEEELDLEADDFDEEDLDEDDDDLEIEEDIIDE DDEDYDDEEEEIK*" /label="rpoE CDS" gene complement(3296857..3297378) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /label="rpoE gene" downshifts complement(3296913) /Source="Nicolas_upshifts" /id="D1922" /incds=0 /nref=7 /ntot=182 /MaxReadThrough="6.49215" /MaxDrop="3.2129" /score="19.8764263" /energy="-19.4" /TU="U2928,U2929" /idTUdmin="U2927" /TUdmin="-1892" /isTUend="FALSE" /label="downshifts" S_feature complement(3297379..3297481) /Source="Nicolas_S_feature" /locus_tag="new_3813064_3813166_c" /HighExp="H2O2, Paraq, Oxctl, LBGexp, G180, dia15, dia0, Lbexp, BMM, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1442" promotor_-10 complement(3297462..3297481) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3297481) /Source="Nicolas_upshifts" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3297483..3297560) /Source="Nicolas_S_feature" /locus_tag="new_3813168_3813245_c" /HighExp="T0.30H, S8, S7, S6, S4, S3, S5, Sw, BC, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1443" promotor_-35 complement(3297497..3297500) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3297561..3298700) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase" /protein_id="NP_391598.1" /db_xref="EnsemblGenomes-Gn:BSU37170" /db_xref="EnsemblGenomes-Tr:CAB15745" /db_xref="GOA:P45867" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG11239" /db_xref="UniProtKB/Swiss-Prot:P45867" /translation="MNFSLSEEHEMIRKLVRDFAKHEVAPTAAERDEQERFDRELFRE MANLGLTGIPWPEDYGGIGSDYLAYVIAVEELSKVCASTGVTLSAHISLCSWPLFAFG TEEQKTEYLTQLALGEKIGAFALTEAGSGSDAGSMKTTAERIGDDYVLNGSKVFITNG GVADIYIVFAVTDPEKKKKGVTAFIVEKDFEGFFTGKKEKKLGIRSSPTTEIMFEDCV VPASKRLGEEGEGFKIAMKTLDGGRNGIAAQAVGIAQGALDAALQYAKERKQFGKSIA EQQGIAFKLADMATMIEASRLLTYQAAWLESSGLPYGKASAMSKLMAGDTAMKVTTEA VQIFGGYGYTKDYPVERYMRDAKITQIYEGTQEIQRLVISRMLAD*" /label="acdA CDS" gene complement(3297561..3298700) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /label="acdA gene" CDS complement(3298697..3300814) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative iron-sulphur-binding reductase" /protein_id="NP_391599.1" /db_xref="EnsemblGenomes-Gn:BSU37180" /db_xref="EnsemblGenomes-Tr:CAB15746" /db_xref="GOA:P45866" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11311" /db_xref="UniProtKB/Swiss-Prot:P45866" /translation="MSGFLIANALLFLIVTAYAVYLFVYLVKTRLAYIKLGQKEQFDQ RFKERLHAIWVNVFGQKKLLKDKKSGIIHVMFFYGFILVQFGAIDFIIKGLAPGRNLS LGPVYPAFTFFQEIVTFLILIAVGWAFYRRYIEKLVRLKRGFKAGLVLIFIGGLMLTV LLGNGMNLIWHEHGLSWSEPIASGIAFMLSGVGKTGAAVIFYIAWWIHLLFLLSFLVY VPQSKHAHLIAGPANVFFNRMESAGKLEKIDFTDETKESYGAGKIEDFRQSQLLDLYA CVECGRCTNMCPATGTGKMLSPMDLILRLRDHLTEKGAAVTSRSPWVPAAAFRHTRGN QLAAASAGSGSQEAAAALDYNPSLIGDVITEEEIWACTTCRNCEDQCPVMNEHVDKII DLRRYLVLTEGKMDSDAQRAMTSIERQGNPWGLNRKERENWRDEAPDAEIPTVKEMKK EGKEFEYLFWVGSMGSYDNRSQKIAISFAKLLNHAGVSFAILGNKEKNSGDTPRRLGN EFLFQELAEKNISEFEKNDVKKIVTIDPHAYNLFKNEYPDFGFEGEVYHHTEVLAELV KNGKLRPQHPLHETITFHDSCYLGRYNEVYDPPREILKAIPGVQLVEMERSRETGMCC GAGGGLMWMEEETGNRINVARTEQALAVNPSVISSGCPYCLTMLGDGTKAKEAEDQVK TYDVVELLAQSVLGADLKMGEKQ*" /label="fadF CDS" gene complement(3298697..3300814) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /label="fadF gene" S_feature complement(3300815..3300873) /Source="Nicolas_S_feature" /locus_tag="new_3816500_3816558_c" /HighExp="T0.30H, S6, BC, S8, S7, Sw, S5, S4, Lbstat, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1444" promotor_-10 complement(3300874..3300893) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3300887) /Source="Nicolas_upshifts" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3300907..3300914) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3300913..3300919 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3300933..3300944 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3300938 /Source="Nicolas_upshifts" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="upshifts" CDS 3300969..3302165 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14973018, 16514141, 18820022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16514141, 18820022; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase (phospholipase D family)" /protein_id="NP_391600.1" /db_xref="EnsemblGenomes-Gn:BSU37190" /db_xref="EnsemblGenomes-Tr:CAB15747" /db_xref="GOA:P45865" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="SubtiList:BG11310" /db_xref="UniProtKB/Swiss-Prot:P45865" /translation="MKVFIVIMIIVVIFFALILLDIFMGRAGYRKKAYEPVFSKKKSD IELIHCGADLVERMMNDIRQAASSVHMMFFIMKNDEVSHNMYTLLKTKAQAGVSVYLL LDWAGCRAIKKTALQTMKNAGVHVHVMNRPRFPFFFFHMQKRNHRKITVIDGKIGYIG GFNIAEEYLGKKAKFGNWEDYHLRMIGEGVHDLQTLFASDLKRNTGIELGSDVWPKLQ QGTISHKIYATDGYSLENIYLANIAQAKNRLTVCTPYYIPSKPLQEALINARKNGVSV RIIVPMKSDHPLVREAAFTYYSELLDAGCLIYRYYQGFYHVKALIIDDHLSIIGTANF DKRSLFLNEEVNVEIDDEAFTSEVYATIEEDMKKSELLTMEDFSKRTFRQRPAEWLGR ALSYFL*" /label="clsB CDS" gene 3300969..3302165 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /label="clsB gene" S_feature complement(3301161..3302039) /Source="Nicolas_S_feature" /locus_tag="new_3816846_3817724_c" /HighExp="S4, S5, S3, S6, S7, S8, BT, B36, LoTm, B60" /AntisenseName="clsB" /AntisenseCor="0.84883232203587" /AntisenseRegPval="-75.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1445" promotor_-10 complement(3302029..3302047) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3302040) /Source="Nicolas_upshifts" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3302063..3302068) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3302178..3303140 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /EC_number="3.-.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8614629, 22961846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8614629, 22961846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UV DNA damage repair endonuclease" /protein_id="NP_391601.1" /db_xref="EnsemblGenomes-Gn:BSU37200" /db_xref="EnsemblGenomes-Tr:CAB15748" /db_xref="GOA:P45864" /db_xref="InterPro:IPR004601" /db_xref="InterPro:IPR023520" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11309" /db_xref="UniProtKB/Swiss-Prot:P45864" /translation="MIFRFGFVSNAMSLWDASPAKTLTFARYSKLSKTERKEALLTVT KANLRNTMRTLHYIIGHGIPLYRFSSSIVPLATHPDVMWDFVTPFQKEFREIGELVKT HQLRTSFHPNQFTLFTSPKESVTKNAVTDMAYHYRMLEAMGIADRSVINIHIGGAYGN KDTATAQFHQNIKQLPQEIKERMTLENDDKTYTTEETLQVCEQEDVPFVFDFHHFYAN PDDHADLNVALPRMIKTWERIGLQPKVHLSSPKSEQAIRSHADYVDANFLLPLLERFR QWGTNIDFMIEAKQKDKALLRLMDELSSIRGVKRIGGGALQWKS*" /label="uvsE CDS" gene 3302178..3303140 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /label="uvsE gene" promotor_-35 3303154..3303160 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3303175..3303193 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3303175 /Source="Nicolas_upshifts" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="upshifts" CDS 3303221..3303493 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391602.1" /db_xref="EnsemblGenomes-Gn:BSU37210" /db_xref="EnsemblGenomes-Tr:CAB15749" /db_xref="InterPro:IPR035895" /db_xref="SubtiList:BG11308" /db_xref="UniProtKB/Swiss-Prot:P45863" /translation="MKNIKSLKVAAQAFTLRNLIHLYKMCHSGSHEVYIYSKKTMCKI KSLIELETFRMAHNEKEYLIVVEGTKASQLIEKFQNLIEPAEREAL*" /label="ywjC CDS" gene 3303221..3303493 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /label="ywjC gene" downshifts complement(3303227) /Source="Nicolas_upshifts" /id="D1923" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="1.03516" /MaxDrop="5.08765" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=330 /isTUend="FALSE" /label="downshifts" downshifts 3303483 /Source="Nicolas_upshifts" /id="D1924" /incds=0 /nref=54 /ntot=128 /MaxReadThrough="4.49396" /MaxDrop="7.49636" /score="14.0189582" /energy="-10" /TU="U2932" /idTUdmin="U2930" /TUdmin=178 /isTUend="FALSE" /label="downshifts" S_feature 3303528..3303934 /Source="Nicolas_S_feature" /locus_tag="new_3819213_3819619" /HighExp="Etha, C30, Sw, Gly, C90, M/G, BC, Salt, Fru, G135" /AntisenseName="ywjB" /AntisenseCor="0.2646821361217" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1446" CDS complement(3303535..3304059) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391603.1" /db_xref="EnsemblGenomes-Gn:BSU37220" /db_xref="EnsemblGenomes-Tr:CAB15750" /db_xref="GOA:P45862" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG11307" /db_xref="UniProtKB/Swiss-Prot:P45862" /translation="MERKTVLYIAVSLDGMIAKEDGSIDWLDEFEGEGDNGYSDFYQT VDTVILGRSTYEHVKVLTPVFPYQDKTCYVFTGSPDSYQDEHVTFINEGARAFTARLK QEKGSNIWIAGGAELVNDFMKEDAIDEFIITVIPVVLGSGIPLFHELTNETKLRLKGT KQFGQAVQLHYVRA*" /label="ywjB CDS" gene complement(3303535..3304059) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /label="ywjB gene" downshifts complement(3303557) /Source="Nicolas_upshifts" /id="D1925" /incds=0 /nref=194 /ntot=239 /MaxReadThrough="1.38978" /MaxDrop="6.19859" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3304069..3305796) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12119303, 12354229, 25652542; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC lipid transporter (ATP-binding protein)" /protein_id="NP_391604.1" /db_xref="EnsemblGenomes-Gn:BSU37230" /db_xref="EnsemblGenomes-Tr:CAB15751" /db_xref="GOA:P45861" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11306" /db_xref="UniProtKB/Swiss-Prot:P45861" /translation="MLRQFFSYYKPYKTLFFLDFFSAIAGGLMELSFPLIVNYFIDTL LPGRDWGLIIATSIGLFAVYALSSALQYIVTYWGHMLGINIETDMRKSLFDHLQKLSF KFYDNNKTGTLMSKLTNDLMYIGEVAHHGPEDLFIAVMTILGAFGVMLFINWQLALLT FIIMPIVIWLALYFNKKMTKAFTTLNKDIGDFSARVENNIGGIRLVQAFGNEAFEKER FAVNNQRFRVTKLSSYKIMAKNGSISYMLTRFVTLFVLLCGTWFVIRGSLSYGEFVAF VLLTNVLFRPIDKINAIIEMYPRGIAGFKSYMELMETEPDIQDSPDSKDVSGLKGNIR YKHVSFGYDDHHNVLNDINLSIQAGETVAFVGPSGAGKSTLCSLLPRFYEASEGDITI DGISIKDMTLSSLRGQIGVVQQDVFLFSGTLRENIAYGRLGASEEDIWQAVKQAHLEE LVHNMPDGLDTMIGERGVKLSGGQKQRLSIARMFLKNPSILILDEATSALDTETEAAI QKALQELSEGRTTLVIAHRLATIKDADRIVVVTNNGIEEQGRHQDLIEAGGLYSRLHQ AQFGQMVHR*" /label="ywjA CDS" gene complement(3304069..3305796) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /label="ywjA gene" promotor_-10 complement(3305830..3305849) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3305844) /Source="Nicolas_upshifts" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3305863..3305869) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3305885..3307387) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /EC_number="2.7.8.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14973018, 15743965, 16514141, 26025016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase" /protein_id="NP_391605.1" /db_xref="EnsemblGenomes-Gn:BSU37240" /db_xref="EnsemblGenomes-Tr:CAB15752" /db_xref="GOA:P45860" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG11305" /db_xref="UniProtKB/Swiss-Prot:P45860" /translation="MLKRRLEFFFLYMMLIGAYVIWFFPVSRLEFYGGLLCYISIILF SIYSLILENRTSQHTLLWIHILVFFPIVGYVFYLFSGQLYVKGKLFKTKRMYNREKLR KLFDKEETPEVTGLKDNQERFFTYSIRAAHMNINTKSNIKVLKNGEETFPDIFKAMRK AESYIHIEYYMFKSDMLGRGMMDIMMEKARQGVEVRFLYDAAGSMKLARRDIMRMKQA GVDIVPFSPLKYGFFNQKLNFRNHRKIVIIDGKTGFVGGLNVGKEYISRDPYIGFWRD THLRLEGEIVQTLHAIFMLDWEYVSNEVLIDQEEYNTPVPVEGGGIYQIVATGPDMKE SMSDLYYEMISSAQKSIWIATPYFVPNESIRTALKAAATKGVEVRVMVPEKNDSFLTQ YASRSYFPELLLEGIEVYSYQKGFMHQKVMIIDGDLASVGTANMDMRSFQLNFEVNVF FTDAEAIRTLEAHFEEDMQESEKLSPVGFYKRGVADRTKESFARLFSGVL*" /label="clsC CDS" gene complement(3305885..3307387) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /label="clsC gene" promotor_-10 complement(3307411..3307429) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3307429) /Source="Nicolas_upshifts" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3307444..3307450) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3307474..3307846) /Source="Nicolas_S_feature" /locus_tag="new_3823159_3823531_c" /HighExp="Lbtran, M40t45, nit, LBGtran, LBGstat, S0, ferm, M0t45, Lbstat, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30294500000000002" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S1447" downshifts complement(3307517) /Source="Nicolas_upshifts" /id="D1926" /incds=0 /nref=4 /ntot=19 /MaxReadThrough="2.94229" /MaxDrop="4.09744" /score="13.5274489" /energy="-11.4" /TU="NA" /idTUdmin="U2935" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3307873..3308544) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (gamma subunit)" /protein_id="NP_391606.1" /db_xref="EnsemblGenomes-Gn:BSU37250" /db_xref="EnsemblGenomes-Tr:CAB15753" /db_xref="GOA:P42177" /db_xref="InterPro:IPR003816" /db_xref="InterPro:IPR023234" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11084" /db_xref="UniProtKB/Swiss-Prot:P42177" /translation="MSGQILWGIMPYIVLTIFIGGHIYRYQHDQFGWTAKSSELLEKK KLAAGSTLFHWGLLCVVGGHVMGILIPEGVYASLGISEHMYHKMAIGAGLPAGIAACT GLVILTYRRLFDKRIRKTSSPSDILTLLLLLFMMLSGVAATFLNIDSKGFDYRTTVGP WFREIVLFRPDASLMESVPLWFKFHIVIGYVVFILWPFTRLVHVFSLPLKYLTRSYVV YRKRS*" /label="narI CDS" gene complement(3307873..3308544) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /label="narI gene" downshifts complement(3307891) /Source="Nicolas_upshifts" /id="D1927" /incds=0 /nref=4 /ntot=13 /MaxReadThrough="6.70789" /MaxDrop="4.50566" /score="27.8375931" /energy="-11.7" /TU="U2935" /idTUdmin="U2935" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(3308541..3309095) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase molybdenum cofactor assembly chaperone NarJ" /protein_id="NP_391607.1" /db_xref="EnsemblGenomes-Gn:BSU37260" /db_xref="EnsemblGenomes-Tr:CAB15754" /db_xref="GOA:P42178" /db_xref="InterPro:IPR003765" /db_xref="InterPro:IPR020945" /db_xref="InterPro:IPR036411" /db_xref="SubtiList:BG11083" /db_xref="UniProtKB/Swiss-Prot:P42178" /translation="MNTTDRQITFSALSCLLSYPDEEWRAELPDWKALIQEIGNRQIR EKLLHFFETSASYSPEALIEHYVYTFDFGKKTNMYVTYFNSGEQRERGIELLHLKNTY EQSGFLPTEKELPDYLPLMLEFAAAAEIEAARSVFEKYLSNVRELASRLEKNDSIYAE LLHVLLAALENIGVRESVEGAVQA*" /label="narJ CDS" gene complement(3308541..3309095) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /label="narJ gene" CDS complement(3309121..3310584) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (beta subunit)" /protein_id="NP_391608.1" /db_xref="EnsemblGenomes-Gn:BSU37270" /db_xref="EnsemblGenomes-Tr:CAB15755" /db_xref="GOA:P42176" /db_xref="InterPro:IPR006547" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR029263" /db_xref="SubtiList:BG11082" /db_xref="UniProtKB/Swiss-Prot:P42176" /translation="MKIKAQIGMVMNLDKCIGCHTCSVTCKNTWTNRSGAEYMYFNNV ETKPGIGYPKQWEDQDKYKGGWTLKKGKLELKSGSKTNRLAGLFYNPNQPSIDDYYEP WNYDYETLTNSPQKKHQPVARPKSSLTGDFMNIEWGPNWEDDLAGGHITGLEDPNVQK MEESIKTEFDDVFMMYLPRICEHCINPACVSSCPSGAMYKREEDGIVLVDQNACRSWR YCVSSCPYKKVYFNWQTNKAEKCTLCFPRLEAGLPTICSETCVGRIRYLGVMLYDADK VEEAASVENEKDLYHSQLDVFLDPNDPEVAKLAKEQGIPAEWIEAAQQSPIYKMIIDW KIALPLHPEYRTLPMVWYIPPLSPIMNLFEGKGSRQTAEDIFPAIDQMRIPIDYLAQL LTAGDTDHIRSTLKKMSVMRQYMRAVQTNKSIDPELISSVGLTEQQIEDMYRLLAIAK YDDRFVIPSSHREEVSDLYAEQGSCGLSFSGGPGSCF*" /label="narH CDS" gene complement(3309121..3310584) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /label="narH gene" CDS complement(3310574..3314260) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /EC_number="1.7.5.1" /EC_number="1.7.99.4" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11289299, 7557333, 7860592, 8846791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (alpha subunit)" /protein_id="NP_391609.2" /db_xref="EnsemblGenomes-Gn:BSU37280" /db_xref="EnsemblGenomes-Tr:CAB15756" /db_xref="GOA:P42175" /db_xref="InterPro:IPR006468" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="InterPro:IPR028189" /db_xref="SubtiList:BG11081" /db_xref="UniProtKB/Swiss-Prot:P42175" /translation="MKKKKRSPLFRRLNYFSPIEHHSNKHSQTTREDRDWENVYRNRW QYDKVVRSTHGVNCTGSCSWNIYVKNGIVTWEGQNLNYPSTGPDMPDFEPRGCPRGAS FSWYIYSPLRVKYPYVRGVLINLWREALQTHQNPLEAWKSIVENPEKAKSYKQARGKG GFVRAEWPEVLKLISASLLYTVMKYGPDRNVGFSPIPAMSMISHASGSRFMSLIGGPM LSFYDWYADLPPASPQIWGDQTDVPESSDWYNSGYIITWGSNVPLTRTPDAHFLAEAR YKGAKVISISPDFAESSKFADDWLSIRQGTDGALAMAMGHVILQEFYVNQETERFIEY AKQYTDFPFLVTLSKENGVYTAGRFLHAKDIGRKTKHDQWKPAVWDEQTSSFAIPQGT MGSRWDGQQKWNLHMIDEETGEPIEPRLSVLGIEDEIGTVRIPYFSNDGNKVLERDLP IKKMNLNGEETYITTVFDLILANYGVNRGIGERSAVSYDDPEPFTPAWQEQMTGIKKE AVVKIAREFAQNAIDTDGRSMIIVGAGINHWFNSDTIYRAVLNLVLLVGAQGVNGGGW AHYVGQEKLRPAEGWQTIATAKDWEGVPKLQNGTSFFYFATDQWRYEDQPISDLASPI AASSRYKHHADYNVLAARLGWLPSYPTFNQNGIDLYKEAEKAGAATPEDVGAYVASQL QEKKLKFAIEDPDNEVNFPRNLFVWRANLISSSGKGHEYFLKHLLGTTNGLMNDDSDS IRPEEIKWREQAPEGKLDLLINLDFRMAGTALYSDIVLPAATWYEKHDLSSTDMHPFI HPFAPAISAPWESKSDWDIFKALSKAVSDLAEEVDMEPVKEVVATPLLHDTMQELAQP FGKINDWSKGECEAIPGKTMPNIQVVERDYKHIFHKMTALGPNVALKPSGTKGMSWSI ADEYESLKQRLGEITSDSVAKGCPNISEAKQAAEAILTLSSTSNGKVAVKAWESLENI TNLKLKDLAEEREEECFTFEQITAQPKTVITSPAFTGSEKGGRRYSPFTTNVEKLIPW RTLTGRQSYYVDHELMMEFGETMATFKPILQHRPFLSKRPDQEGKEIVLNYLTPHNKW SVHSMYFDSLPMLTLFRGGPTVWMNKDDAEDTDIKDNDWIECFNRNGVVVARAVLSHR IPKGMAFMHHAQDRHINVPGTKLTNNRGGTHNSPTRIHVKPTQMIGGYAQLSYGFNYY GPTGNQRDLNVVIRKLKEVDWLED*" /label="narG CDS" gene complement(3310574..3314260) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /label="narG gene" misc_feature complement(3314291..3314310) /Source="Nicolas_upshift_promotors" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3314315) /Source="Nicolas_upshifts" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3314317..3314446) /Source="Nicolas_S_feature" /locus_tag="new_3830002_3830131_c" /HighExp="Lbtran, M40t45, LBGtran, ferm, M0t45, nit, S0, Lbstat, LBGstat, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1448" CDS complement(3314456..3314932) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 11698370, 16428414, 22178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 11698370, 16428414, 22178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_391610.1" /db_xref="EnsemblGenomes-Gn:BSU37290" /db_xref="EnsemblGenomes-Tr:CAB15757" /db_xref="GOA:P46910" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018490" /db_xref="SubtiList:BG11345" /db_xref="UniProtKB/Swiss-Prot:P46910" /translation="MNQCDYLLFLKQLPMFNEVPLSIVETLLKNGTFIRGSCDQSPSF LHSQSVYIVLKGSVRFMDTRLPEGSKTVALWEKGDVFPIDEKGGLYLSPFISVNATSD ILILNIPYYIFKKMMSYHPQLQMNFLAMLQQNVFCSYQLFLRYLHTSQDENAEPGS*" /label="arfM CDS" gene complement(3314456..3314932) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /label="arfM gene" downshifts complement(3314491) /Source="Nicolas_upshifts" /id="D1928" /incds=0 /nref=10 /ntot=39 /MaxReadThrough="5.03469" /MaxDrop="3.83412" /score="30.7487171" /energy="-10.5" /TU="U2936" /idTUdmin="U2936" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3314955..3314974) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-10" upshifts complement(3314967) /Source="Nicolas_upshifts" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="upshifts" promotor_-35 complement(3314989..3314992) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-35" upshifts 3315039 /Source="Nicolas_upshifts" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3315042..3315061 /Source="Nicolas_upshift_promotors" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3315076..3315795 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16428414, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391611.1" /db_xref="EnsemblGenomes-Gn:BSU37300" /db_xref="EnsemblGenomes-Tr:CAB15758" /db_xref="GOA:P46909" /db_xref="InterPro:IPR025576" /db_xref="SubtiList:BG11344" /db_xref="UniProtKB/Swiss-Prot:P46909" /translation="MKALIPKQHGAWAMLLIPFLLGMVKGGPVIWHIPLFLGWLFLYL AVYPVTLALKKKQSKPYQKWMCYYGFPTCCFLMISVFHKPPLIWVGVSLLPLFLIHMY FARRKNERALLNDVAGVLFFCSGGFASCWLGMGTLDGWAWFIFLQSALFFIGSSFYVK SVIRERKNRAFAYWSWGYHLLLPFLSALFGAGWAFLAFIPSSLRAWFFHGRDWPVKTI GILEIVNACFFLAVMCLFITR*" /label="ywiC CDS" gene 3315076..3315795 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /label="ywiC gene" downshifts 3315779 /Source="Nicolas_upshifts" /id="D1929" /incds=0 /nref=14 /ntot=34 /MaxReadThrough="2.00369" /MaxDrop="5.63285" /score="-3.54009378" /energy="-5.8" /TU="NA" /idTUdmin="U2937" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3315827..3316543) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 16796679, 21068385, 23046954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 16796679, 21068385, 23046954; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of anaerobic metabolism (FNR/CAP family)" /protein_id="NP_391612.1" /db_xref="EnsemblGenomes-Gn:BSU37310" /db_xref="EnsemblGenomes-Tr:CAB15759" /db_xref="GOA:P46908" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR012318" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018335" /db_xref="InterPro:IPR018490" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11343" /db_xref="UniProtKB/Swiss-Prot:P46908" /translation="MNFLSVRPSDSDLISSDLYELLESISTKRKMEKHTYLFREGMDA EELYLIQSGLIEIGKLTSDGKDLTLRICQKHDIVGELTLFTEEPRYMLSAKVLEDGEV LVINKNKLEKELIQNGALTFEFMKWMSTHLRKIQSKIRDLLLHGKKGALYSTLIRLSN SYGVERSDGILINIVLTNQDLAKFCAAARESVNRMLGDLRKKGVISIDESGKIILHKR DYLRCEIECENCPLEICNID*" /label="fnr CDS" gene complement(3315827..3316543) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /label="fnr gene" downshifts complement(3315829) /Source="Nicolas_upshifts" /id="D1930" /incds=0 /nref=116 /ntot=238 /MaxReadThrough="3.06242" /MaxDrop="8.21489" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-84" /isTUend="FALSE" /label="downshifts" downshifts complement(3315899) /Source="Nicolas_upshifts" /id="D1931" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.51297" /MaxDrop="3.71248" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" misc_feature complement(3316569..3316588) /Source="Nicolas_upshift_promotors" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3316581) /Source="Nicolas_upshifts" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3316642..3317829) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 15849754, 16796679, 16850406, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 15849754, 16796679, 16850406, 26786044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite extrusion permease" /protein_id="NP_391613.2" /db_xref="EnsemblGenomes-Gn:BSU37320" /db_xref="EnsemblGenomes-Tr:CAB15760" /db_xref="GOA:P46907" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11342" /db_xref="UniProtKB/Swiss-Prot:P46907" /translation="MINRQHIQLSLQSLSLVAGFMVWVLISSLISQITLDIHLSKGEI SLVTAIPVILGSLLRIPLGYLTNRFGARLMFMVSFILLLFPVFWISIADSLFDLIAGG FFLGIGGAVFSIGVTSLPKYYPKEKHGVVNGIYGAGNIGTAVTTFAAPVIAQAVGWKS TVQMYLILLAVFALLHVLFGDRHEKKVKVSVKTQIKAVYRNHVLWFLSLFYFITFGAF VAFTIYLPNFLVEHFGLNPADAGLRTAGFIAVSTLLRPAGGFLADKMSPLRILMFVFA GLTLSGIILSFSPTIGLYTFGSLTVAVCSGIGNGTVFKLVPFYFSKQAGIANGIVSAM GGLGGFFPPLILASVFQATGQYAIGFMALSEVALASFVLVIWMYWQERMKTHTERNSQ SIN*" /label="narK CDS" gene complement(3316642..3317829) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /label="narK gene" misc_feature complement(3317859..3317878) /Source="Nicolas_upshift_promotors" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3317877) /Source="Nicolas_upshifts" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3317965..3319635) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /EC_number="6.1.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8289305, 9862121" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8289305, 9862121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginyl-tRNA synthetase" /protein_id="NP_391614.1" /db_xref="EnsemblGenomes-Gn:BSU37330" /db_xref="EnsemblGenomes-Tr:CAB15761" /db_xref="GOA:P46906" /db_xref="InterPro:IPR001278" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR005148" /db_xref="InterPro:IPR008909" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR035684" /db_xref="InterPro:IPR036695" /db_xref="SubtiList:BG11341" /db_xref="UniProtKB/Swiss-Prot:P46906" /translation="MNIAEQMKDVLKEEIKAAVLKAGLAEESQIPNVVLETPKDKTHG DYSTNMAMQLARVAKKAPRQIAEEIVAHFDKGKASIEKLDIAGPGFINFYMNNQYLTK LIPSVLEAGEAYGETNIGNGERVQVEFVSANPTGDLHLGHARGAAVGDSLCNVLSKAG YDVSREYYINDAGNQINNLALSVEVRYFEALGLEKPMPEDGYRGEDIIAIGKRLAEEY GDRFVNEEESERLAFFREYGLKYELEKLRKDLENFRVPFDVWYSETSLYQNGKIDKAL EALREKGHVYEEDGATWFRSTTFGDDKDRVLIKKDGTYTYLLPDIAYHKDKLDRGFDK LINVWGADHHGYIPRMKAAIEALGYEKGTLEVEIIQLVHLYKNGEKMKMSKRTGKAVT MRDLIEEVGLDAVRYFFAMRSADTHMDFDLDLAVSTSNENPVYYAQYAHARICSMLRQ GEEQGLKPAADLDFSHIQSEKEYDLLKTIGGFPEAVAEAAEKRIPHRVTNYIYDLASA LHSFYNAEKVIDPENEEKSRARLALMKATQITLNNALQLIGVSAPEKM*" /label="argS CDS" gene complement(3317965..3319635) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /label="argS gene" downshifts complement(3317967) /Source="Nicolas_upshifts" /id="D1932" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="1.71727" /MaxDrop="6.56513" /score="23.3947976" /energy="-12.5" /TU="NA" /idTUdmin="U2941" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3319632..3320060) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_391615.1" /db_xref="EnsemblGenomes-Gn:BSU37340" /db_xref="EnsemblGenomes-Tr:CAB15762" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR015231" /db_xref="PDB:1R0U" /db_xref="SubtiList:BG14161" /db_xref="UniProtKB/Swiss-Prot:O07624" /translation="MKQETPITLHVKSVIEDDGNQEVIEFRTTGFYYVKQNKVYLSYY EEHDLGKVKTIVKVSEGEVLVMRSGAVKMNQRFVTGASTIAKYKMSFGELELKTSTKS IQSDLDEEKGRISIAYDMHVGDEQEHLHNMTITYEGGTHA*" /label="ywiB CDS" gene complement(3319632..3320060) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /label="ywiB gene" misc_feature 3320128..3320142 /Source="Nicolas_upshift_promotors" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3320128..3320147) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3320135 /Source="Nicolas_upshifts" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3320144) /Source="Nicolas_upshifts" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3320164..3320167) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3320199..3320218) /Source="Nicolas_upshift_promotors" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3320211) /Source="Nicolas_upshifts" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="upshifts" SCAR join(3320240,3320247) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs09" N_region 3320241..3320246 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs09" S_feature <3320247..3322725 /Source="Nicolas_S_feature" /locus_tag="new_3842996_3845478" /HighExp="Lbstat, nit, ferm, BI, M0t90, S2, M40t90, BT, M0t45, GM 150" /AntisenseName="ywhL" /AntisenseCor="7.7827453562424306E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.99, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1450" CDS complement(3320248..3321624) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12073041" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391624.1" /db_xref="EnsemblGenomes-Gn:BSU37440" /db_xref="EnsemblGenomes-Tr:CAB15771" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12464" /db_xref="UniProtKB/Swiss-Prot:P71004" /translation="MKKNDLSALQENCFCFCDEEISREAPFQVPIDFPEGFKVDTAEA SAAVTWSTDNLSCISEPCLIQTGPEPEDIGVRYAVRVQGTITLLVSVSPVRNQYGQGD GAVSVIHTEEIDQVVYYAAQSGRCPDFSQITVEDLLIVPPFYGSPLTVAGTLVLPPSP DPQSYVFTANTGDSTVSVIDADLNTVVKTIPFSDVPTNLGVTFDKAFTYVLHGNTNLV SVIDNKTLTIINTITVGGGPRKIEFDPTDEFAYVMAAGSIYVINTASQSVIDVIPIPG ALDFALDPNGQYVYTANGSSWSVDKYDVNTGQLVESIIDTFEFPSLITTPYAGNFAYV LNGELWPKGVTEISLSPLSRGGDFSRLFETLRTIVFSLDSTRAYFLEPYSEPFLINNL YVVNTARQRIIANVSLPGAFDLAVTPDKQYIYAAQPNDNAVTVYRTSDYTAVTVIPVG AGPSAIAM*" /label="ywhL CDS" gene complement(3320248..3321624) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /label="ywhL gene" CDS complement(3321663..3323018) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12073041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073041; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DNA helicase PcrA" /protein_id="NP_391625.1" /db_xref="EnsemblGenomes-Gn:BSU37450" /db_xref="EnsemblGenomes-Tr:CAB15772" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12463" /db_xref="UniProtKB/Swiss-Prot:P71003" /translation="MRKNKLSFKEKAGAEQEECLCFCEGEASREAMFQAPIELPEGFV VDPAEAVANVTWNADSLSCVSDRCLIQTGPEPDEVGVQFAVRLQGTVTLLVSVSPVRN QYGQGDGAVSVIHNAEIDQVVYYSDESDDCPDISDITIENLVVVPPFYGSPLSVTGTI VLVPEPEPVYAFTANPNDQSVSVIDTNTDTVVTTIALPYNPAGIEITPDKSAVFVLHP NNNVISVIDYDTLTVTATILLDQPPRLIRFIPNHEFAYVFTGTAVYVIGIDTLTVDRS IPVEGYDVAIDPNGLFAYVLNFGIVQKVDLTTGEVTGTIERELIVSTIETNWPERYAY VLEQEFFFNYLTVIDLNTFTISSTQELEYEGEYRMFTSGAEVYLYDGFTGNLYSVSPN GAGVIGNVPQSATDYAFTPNGDFLYATRFIEQSIIVYNTDDYSEETVISLGVSPGAIT I*" /label="ywhK CDS" gene complement(3321663..3323018) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /label="ywhK gene" promotor_-10 complement(3323054..3323073) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3323072) /Source="Nicolas_upshifts" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3323086..3323095) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3323198..3323217 /Source="Nicolas_upshift_promotors" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3323199 /Source="Nicolas_upshifts" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3323244) /Source="Nicolas_upshifts" /id="D1937" /incds=0 /nref=7 /ntot=59 /MaxReadThrough="2.35357" /MaxDrop="4.85842" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=1867 /isTUend="FALSE" /label="downshifts" CDS 3323248..3324393 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase anti-activator of ComA" /protein_id="NP_391626.1" /db_xref="EnsemblGenomes-Gn:BSU37460" /db_xref="EnsemblGenomes-Tr:CAB15773" /db_xref="GOA:P71002" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3ULQ" /db_xref="PDB:4I9C" /db_xref="PDB:4I9E" /db_xref="SubtiList:BG11968" /db_xref="UniProtKB/Swiss-Prot:P71002" /translation="MTGVISSSSIGEKINEWYMYIRRFSIPDAEYLRREIKQELDQME EDQDLHLYYSLMEFRHNLMLEYLEPLEKMRIEEQPRLSDLLLEIDKKQARLTGLLEYY FNFFRGMYELDQREYLSAIKFFKKAESKLIFVKDRIEKAEFFFKMSESYYYMKQTYFS MDYARQAYEIYKEHEAYNIRLLQCHSLFATNFLDLKQYEDAISHFQKAYSMAEAEKQP QLMGRTLYNIGLCKNSQSQYEDAIPYFKRAIAVFEESNILPSLPQAYFLITQIHYKLG KIDKAHEYHSKGMAYSQKAGDVIYLSEFEFLKSLYLSGPDEEAIQGFFDFLESKMLYA DLEDFAIDVAKYYHERKNFQKASAYFLKVEQVRQLIQGGVSLYEIEV*" /label="rapF CDS" gene 3323248..3324393 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /label="rapF gene" promotor_-35 3324252..3324256 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3324273..3324292 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3324280 /Source="Nicolas_upshifts" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3324363) /Source="Nicolas_upshifts" /id="D1938" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="1.70728" /MaxDrop="2.74755" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS 3324377..3324496 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type f: factor" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapF" /protein_id="NP_391627.1" /db_xref="EnsemblGenomes-Gn:BSU37470" /db_xref="EnsemblGenomes-Tr:CAB15774" /db_xref="GOA:P71001" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11960" /db_xref="UniProtKB/Swiss-Prot:P71001" /translation="MKLKSKLLLSCLALSTVFVATTIANAPTHQIEVAQRGMI*" /label="phrF CDS" gene 3324377..3324496 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /label="phrF gene" downshifts 3324481 /Source="Nicolas_upshifts" /id="D1939" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="5.48985" /MaxDrop="6.14096" /score="19.6493244" /energy="-9.9" /TU="U2946" /idTUdmin="U2947" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" S_feature 3324526..3324594 /Source="Nicolas_S_feature" /locus_tag="new_3847279_3847347" /HighExp="S2, S3, S4, S5, S6, S1, BT, S7, S8, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.921" /TUlongSig="NA" /TUlongPSig="NA" /label="S1451" CDS 3324595..3325068 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA editing enzyme" /protein_id="NP_391628.1" /db_xref="EnsemblGenomes-Gn:BSU37480" /db_xref="EnsemblGenomes-Tr:CAB15775" /db_xref="GOA:P71000" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12462" /db_xref="UniProtKB/Swiss-Prot:P71000" /translation="MSLKSVRTHFTQWNRENDVTEFETSSATVEQAAETIGVSLSRIA KSLSFRGEGDQVILIVAAGDAKIDNKKSRQTFGFKARMLSPNEVLEQTGHEIGGVCPF GLAHDPEVYLDVSLKRFQTVFPACGSRNSAIELTPKELSEFSFSKVWIDVCKDWE*" /label="ywhH CDS" gene 3324595..3325068 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /label="ywhH gene" downshifts 3325057 /Source="Nicolas_upshifts" /id="D1940" /incds=0 /nref=30 /ntot=156 /MaxReadThrough="2.85314" /MaxDrop="4.40065" /score="-6.80415499" /energy="-11.3" /TU="NA" /idTUdmin="U2946" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3325100..3325972) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /EC_number="3.5.3.11" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9723923, 10931887, 24678831, 28807600, 28291380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10931887, 24678831, 28807600, 28291380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="agmatinase" /protein_id="NP_391629.1" /db_xref="EnsemblGenomes-Gn:BSU37490" /db_xref="EnsemblGenomes-Tr:CAB15776" /db_xref="GOA:P70999" /db_xref="InterPro:IPR005925" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG12461" /db_xref="UniProtKB/Swiss-Prot:P70999" /translation="MRFDEAYSGKVFIASRPEWEEADAILYGMPMDWTVSYRPGSRFG PSRIREVSIGLEEYSPYLDRDLADLNFFDAGDIPLPFGNPQRSLDMIEEYVDSILEKG KFPMGMGGEHLVSWPVIKAMYKKYPDLAIIHFDAHTDLRVDYEGEPLSHSTPIRKAAE LIGPHNVYSFGIRSGMKEEFEWAKENGMHISKFEVLEPLKEVLPKLAGRPVYVTIDID VLDPAHAPGTGTVDAGGITSKELLASVHEIARSEVNVKGADLVEVAPVYDHSEQTANT ASKIIREMLLGFVK*" /label="speB CDS" gene complement(3325100..3325972) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /label="speB gene" downshifts complement(3325111) /Source="Nicolas_upshifts" /id="D1941" /incds=0 /nref=49 /ntot=171 /MaxReadThrough="2.5482" /MaxDrop="5.46925" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3325177) /Source="Nicolas_upshifts" /id="D1942" /incds=1 /nref=8 /ntot=50 /MaxReadThrough="5.83631" /MaxDrop="3.87062" /score="29.5788849" /energy="-11.3" /TU="U2948" /idTUdmin="U2948" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(3326033..3326863) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /EC_number="2.5.1.16" /function="16.3: Control" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9723923, 26735940, 28546427, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 26735940, 28546427, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spermidine synthase; polyamine metabolism" /protein_id="NP_391630.1" /db_xref="EnsemblGenomes-Gn:BSU37500" /db_xref="EnsemblGenomes-Tr:CAB15777" /db_xref="GOA:P70998" /db_xref="InterPro:IPR001045" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030373" /db_xref="InterPro:IPR030374" /db_xref="InterPro:IPR035246" /db_xref="InterPro:IPR037163" /db_xref="PDB:1IY9" /db_xref="SubtiList:BG12460" /db_xref="UniProtKB/Swiss-Prot:P70998" /translation="MSELWYTEKQTKNFGITMKVNKTLHTEQTEFQHLEMVETEEFGN MLFLDGMVMTSEKDEFVYHEMVAHVPLFTHPNPEHVLVVGGGDGGVIREILKHPSVKK ATLVDIDGKVIEYSKKFLPSIAGKLDDPRVDVQVDDGFMHIAKSENQYDVIMVDSTEP VGPAVNLFTKGFYAGIAKALKEDGIFVAQTDNPWFTPELITNVQRDVKEIFPITKLYT ANIPTYPSGLWTFTIGSKKYDPLAVEDSRFFDIETKYYTKDIHKAAFVLPKFVSDLIK *" /label="speE CDS" gene complement(3326033..3326863) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /label="speE gene" S_feature complement(3326864..3326959) /Source="Nicolas_S_feature" /locus_tag="new_3849617_3849712_c" /HighExp="Paraq, G180, Oxctl, H2O2, LBGexp, G150, G135, C30, dia15, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1452" promotor_-10 complement(3326947..3326966) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3326958) /Source="Nicolas_upshifts" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3326979..3326986) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3327004..3327009 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3327025..3327043 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3327027 /Source="Nicolas_upshifts" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="upshifts" CDS 3327065..3329140 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10767540, 11567005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10767540, 11567005; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation specific penicillin-binding protein 2D" /protein_id="NP_391631.2" /db_xref="EnsemblGenomes-Gn:BSU37510" /db_xref="EnsemblGenomes-Tr:CAB15778" /db_xref="GOA:P70997" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG12459" /db_xref="UniProtKB/Swiss-Prot:P70997" /translation="MDAMTNKRLRLTLKTVRAFIFLGAFAALAAAAVFMTVILIAKYQ GAPSVQVPQSTILYASDGSKLGETNYGEKRYWVPLKDMNPTIVKATVAIEDQNFYDHH GFDYKRMAGAALADLKAFAKVQGASTITQQYARNLYLEHDKTWKRKWNEAFYTIRLEQ NYSKDEILEGYLNTIYYGHGAYGIEAASRLYFGKHAKNLTDAEAALLAGIPKGPSGYS PYVNETKAKERQKTIVRMMEKQQMISQKKADELIKEPLSYQPLNKQVSKRKAPYFYDN AMRELEKKLGMTREQIETSGLNVYTTVDKRMQRIAEETITETVNAGSDIQVGFSAIDP RTGNVLALVGGRDYQKSPFDRTTQAKRQPASTIKPLLYYKAIQSGFTPVTLMKSEETE FQIDAKGETYSPSNYNGYYANKPITLLQALALSDNIYAVKTHLFLGTNKLVKTAKEFG ITAHLQALPSLALGTEPVRPIEMVNAYAMLANGGKKIEPTFISRVTDAAGHVLYENPN QHKQVLDEKAAFVTASMMTGMFDIDLNGYTSVTGRTIANRLTRTYAGKSGTTSADSWM IGFNPKLAAGVWTGYDKNSTIDSVEEKSYAKTIWADFMEDALKGEPETAFKPPKGVTG VYIDPETGYSSGPGCAAKHYTYFVKGTEPANVCYGAEPAKQTKDRLPSKEKPASEKKW WDKWLGRHH*" /label="pbpG CDS" gene 3327065..3329140 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /label="pbpG gene" downshifts complement(3329193) /Source="Nicolas_upshifts" /id="D1943" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="1.43573" /MaxDrop="3.61075" /score="-7.59753556" /energy="-10.7" /TU="NA" /idTUdmin="U2951" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(3329317..3329432) /Source="Nicolas_S_feature" /locus_tag="new_3852070_3852185_c" /HighExp="Sw, C90, BI, dia5, dia15, Diami, LBGexp, M0t45, Lbexp, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1453" downshifts complement(3329360) /Source="Nicolas_upshifts" /id="D1944" /incds=0 /nref=198 /ntot=248 /MaxReadThrough="3.25498" /MaxDrop="6.4287" /score="-7.59753556" /energy="-10.7" /TU="U2951,U2952" /idTUdmin="U2952" /TUdmin="-156" /isTUend="FALSE" /label="downshifts" CDS complement(3329433..3329951) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391632.1" /db_xref="EnsemblGenomes-Gn:BSU37520" /db_xref="EnsemblGenomes-Tr:CAB15779" /db_xref="InterPro:IPR014852" /db_xref="SubtiList:BG12458" /db_xref="UniProtKB/Swiss-Prot:P70996" /translation="MEEKKKKSIGFNIIKSDPTDGHGGFGVGALSLDNISPVFVDVEE KEAFVDIGAMHARSTVEKGIKFLPNKEEVPNGKPYWLVWVTIDRKEEGPYYAGVTACE MTVDRSIRRGYKSLPEHVNLMDKSMKRKIIVDKMDDSSKRVLGEFLKKHDQGLWDRSS DELKTSLLPENN*" /label="ywhD CDS" gene complement(3329433..3329951) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /label="ywhD gene" CDS complement(3329965..3330624) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /EC_number="3.4.24.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase; integral membrane protein" /protein_id="NP_391633.1" /db_xref="EnsemblGenomes-Gn:BSU37530" /db_xref="EnsemblGenomes-Tr:CAB15780" /db_xref="GOA:P70995" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG12457" /db_xref="UniProtKB/Swiss-Prot:P70995" /translation="MDRFLYYPLSLMPYLVITLIVSFTMHELAHAYVAYKFGDDTAKK QGRLTLNPIKHLDPFGTILILVAGFGWARPIPVNRRFFKKPRLAGVLVSIAGPVSNLI LAFIGFFLLVLMHAYGMEMLAAFSTGLDQFFSIWIQLNLVLFLFNLLPLPPLDGYRII EDLVPPGVRAKMTQAESYGFIVFLVLFVTPLGSYVLWPMLNAGRDSILKLFSAIFQPL L*" /label="ywhC CDS" gene complement(3329965..3330624) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /label="ywhC gene" promotor_-35 3330647..3330650 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3330660..3330679) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3330665..3330684 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3330668 /Source="Nicolas_upshifts" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3330678) /Source="Nicolas_upshifts" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3330680..3330963) /Source="Nicolas_S_feature" /locus_tag="new_3853433_3853716_c" /HighExp="Diami, dia5, dia15, C90, Etha, Sw, H2O2, G135, M40t45, Lbtran" /AntisenseName="ywhB" /AntisenseCor="0.10541372702249199" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1454" promotor_-35 complement(3330694..3330701) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3330733..3330921 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /EC_number="5.3.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12051677, 14624569, 14730980, 15301547, 17902707" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12051677, 14624569, 14730980, 15301547, 17902707; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxymuconate tautomerase (promiscuous)" /protein_id="NP_391634.1" /db_xref="EnsemblGenomes-Gn:BSU37540" /db_xref="EnsemblGenomes-Tr:CAB15781" /db_xref="GOA:P70994" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="InterPro:IPR018191" /db_xref="PDB:2OP8" /db_xref="PDB:2OPA" /db_xref="SubtiList:BG12456" /db_xref="UniProtKB/Swiss-Prot:P70994" /translation="MPYVTVKMLEGRTDEQKRNLVEKVTEAVKETTGASEEKIVVFIE EMRKDHYAVAGKRLSDME*" /label="hmtB CDS" gene 3330733..3330921 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /label="hmtB gene" downshifts 3330910 /Source="Nicolas_upshifts" /id="D1945" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="1.74275" /MaxDrop="4.93207" /score="4.21502693" /energy="-10.5" /TU="NA" /idTUdmin="U2950" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3330964..3331383) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391635.1" /db_xref="EnsemblGenomes-Gn:BSU37550" /db_xref="EnsemblGenomes-Tr:CAB15782" /db_xref="GOA:P70993" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12455" /db_xref="UniProtKB/Swiss-Prot:P70993" /translation="MDHDKLEANLLDHALTKYLKSTKQLDEATVPKHVNNVRGFILRI IYRHGSCTIKDILKEVTLSPSATTTALNHLEQEGFIERSRNNNDRRTVWITLSESGRG AAEQMIENRQQLIDGMFERLTAEEKKTFLAIIAKLAQ*" /label="ywhA CDS" gene complement(3330964..3331383) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /label="ywhA gene" promotor_-10 complement(3331433..3331452) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3331444) /Source="Nicolas_upshifts" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3331467..3331474) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3331503..3333419) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9353933, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9353933, 15831787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_391636.2" /db_xref="EnsemblGenomes-Gn:BSU37560" /db_xref="EnsemblGenomes-Tr:CAB15783" /db_xref="GOA:P18256" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10421" /db_xref="UniProtKB/Swiss-Prot:P18256" /translation="MSKHVHIQLPDGQIQEYPKGITIKEAAGSISSSLQKKAAAGQVN GKLVDLSFKLEEDAELSIVTLDSQEGLQVLRHTTAHVLAQAVKRLYGEVSLGVGPVIL DGFYYDMKLGKSLASGDLEAIEKEMKNIINENLEIKRIEVSYEEAEELFAQKDERLKL EILKDIPRGEDITLYQQGEFVDLCRGPHLPSTGMIKAFKLTRVSGAYWRGDSKNEVLQ RVYGVAFQKKKDLDAHLHMLEEAAKRDHRKLGKQLGLFMFSEEAPGMPFYLPKGQIVR NELERFSRELQTNAGYDEVRTPFMMNQRLWEQSGHWDHYRDNMYFSEVDDTRFAMKPM NCPGHMLIFKNSLYSYRDLPIRMAEFGQVHRHEYSGALNGMLRVRTFCQDDAHIFVRE DQIESEIKEAIRLIDEVYRTFGFEYSVELSTRPEDSLGDDSLWEASERALARVLEELG LSYEINEGDGAFYGPKIDFHIKDALKRSHQCATIQLDFQMPEKFDLTYINELNEKVRP VVIHRAVFGSIDRFFGILIEHYGGAFPVWLAPIQVQIIPVSHVHLDYCRKVQAELKQA GIRAGIDERNEKLGYKIRESQVQKIPYVLVLGDHEEQENAVNVRRFGHQQNEHVPFQT FKDKLVKQVENRGM*" /label="thrZ CDS" gene complement(3331503..3333419) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /label="thrZ gene" promotor_-10 complement(3332697..3332715) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3332702) /Source="Nicolas_upshifts" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3332732..3332736) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3333450) /Source="Nicolas_upshifts" /id="D1946" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.2774" /MaxDrop="3.56231" /score="36.3785359" /energy="-19.5" /TU="U2955" /idTUdmin="U2953" /TUdmin="-968" /isTUend="FALSE" /label="downshifts" misc_RNA complement(3333473..3333694) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /product="T-box" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" /label="tboTB RNA" gene complement(3333473..3333694) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /label="tboTB gene" misc_RNA complement(3333726..3333947) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" /label="tboTA RNA" gene complement(3333726..3333947) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /label="tboTA gene" S_feature complement(3333979..3334241) /Source="Nicolas_S_feature" /locus_tag="new_3856732_3856994_c" /HighExp="S8, S7, S6, S5, BT, Sw, B36, B60, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.61719100000000005" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1455" downshifts 3333990 /Source="Nicolas_upshifts" /id="D1947" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="0.92811" /MaxDrop="3.85666" /score="1.17237511" /energy="-8.3" /TU="NA" /idTUdmin="U2950" /TUdmin=3080 /isTUend="FALSE" /label="downshifts" downshifts complement(3334022) /Source="Nicolas_upshifts" /id="D1948" /incds=0 /nref=52 /ntot=200 /MaxReadThrough="6.68945" /MaxDrop="6.6969" /score="36.414771" /energy="-17.3" /TU="U2955" /idTUdmin="U2953" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" CDS complement(3334029..3334184) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514011.1" /translation="MLFTVSREGRTAEIFLTQGKQLTAFEPYQGKQVSDTVMLRYSIF KPIIMCN*" /label="hypothetical protein CDS" gene complement(3334029..3334184) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /label="gene" promotor_-35 3334191..3334194 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3334203..3334216 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3334210 /Source="Nicolas_upshifts" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3334218..3334237) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3334241) /Source="Nicolas_upshifts" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3334251..3334257) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3334264..3335664) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11104814, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11104814, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="toxic compound efflux transporter (may export homoserine)" /protein_id="NP_391637.1" /db_xref="EnsemblGenomes-Gn:BSU37570" /db_xref="EnsemblGenomes-Tr:CAB15784" /db_xref="GOA:Q00538" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10420" /db_xref="UniProtKB/Swiss-Prot:Q00538" /translation="MKNSGSIQESTSSTGISVLIVLALGFLMATLDVTVVNVAMADMK NTLSMSLSGVTWVVDGYILTFASLLLAGGALADRFGSKTIYILGLAVFVMASCLCAAS INGQMLIAGRLIQGIGAALFMPSSLSLLAASYLDERARARMFGLWAALVSAASALGPF IGGVLVQLAGWQSIFLINVPIGAAALISAYRILSRVPGKSSRVNIIGHLLGMMALGFL SYALIQGPSAGWRSPVILVAFTAAVLAFVLFLLREISAKTPILPASLYKNGRFSAAQF IGFLLNFALFGGMFMLSLFLQEAGGASSFMAGVELLPMMAVFVIGNLLFARLANRFEA GQLMFVSMAVSCIIALLLFVLISPDFPYWQLAVLMSVMNLCTGITVPAMTTVIMQAAG QRHTNIAGAALNANRQIGALVGVAITGVIIHLSATWYAGAGFAFLMMGAAYSLAALLV WLFLAAHNGTAASEKM*" /label="mmr CDS" gene complement(3334264..3335664) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /label="mmr gene" CDS complement(3335664..3336134) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885456; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391638.1" /db_xref="EnsemblGenomes-Gn:BSU37580" /db_xref="EnsemblGenomes-Tr:CAB15785" /db_xref="GOA:P71047" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12454" /db_xref="UniProtKB/Swiss-Prot:P71047" /translation="MKMKSGMEQAVSVLLLLSRLPVQASLTSEAISQRLRVSPSYLKK LMRTLVQAGLAESLPGTKGGFTLTKPLADITLYDVYQAVEGRGSMYQGKGLLQSVFEG ESHCVLETVMAEIEDKWSNLMREESLQHVMDRVGELYDLEKIDDWVIKQVKGQL*" /label="ywgB CDS" gene complement(3335664..3336134) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /label="ywgB gene" downshifts complement(3336090) /Source="Nicolas_upshifts" /id="D1949" /incds=0 /nref=11 /ntot=145 /MaxReadThrough="2.78131" /MaxDrop="4.29115" /score="17.3758052" /energy="-11.2" /TU="NA" /idTUdmin="U2956" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3336246..3336746) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391639.1" /db_xref="EnsemblGenomes-Gn:BSU37590" /db_xref="EnsemblGenomes-Tr:CAB15786" /db_xref="SubtiList:BG12453" /db_xref="UniProtKB/Swiss-Prot:P71046" /translation="MLKEHAKLMKVFSDSGEIIGRKKLQKMIYIAKKMQFPFYEKYDF HFYGPYSEELTLQIEELCNLGFLHEVKEKKGGYFQYRYSLTETGSAFLDHADLDMPDM KGYIDSVNSRSSRFLELVSTILYFDGLEDEEKKEKVFTIKSKQKYTNEEYDEALQYIE ELKQIC*" /label="ywgA CDS" gene complement(3336246..3336746) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /label="ywgA gene" downshifts complement(3336249) /Source="Nicolas_upshifts" /id="D1950" /incds=0 /nref=9 /ntot=105 /MaxReadThrough="4.00805" /MaxDrop="6.12059" /score="17.3758052" /energy="-11.2" /TU="U2956,U2957" /idTUdmin="U2957" /TUdmin="-137" /isTUend="FALSE" /label="downshifts" CDS complement(3336782..3338083) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent nucleotide (pyro)phosphohydrolase" /protein_id="NP_391640.1" /db_xref="EnsemblGenomes-Gn:BSU37600" /db_xref="EnsemblGenomes-Tr:CAB15787" /db_xref="GOA:P39651" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG10639" /db_xref="UniProtKB/Swiss-Prot:P39651" /translation="MAYPNGKLSEEKVFKDPVHRYVHVRDKLIWDLIGTREFQRLRRI KQLGTTYLTFHGAEHSRFNHSLGVYEIVRRMVDDVFKGRPEWDDSERELCLAAALLHD LGHGPFSHSFEKVFHLDHEDFTRGIILGDTEVNQVLRKVSPGFPQDVAEVIAKTYKNK QVVSLISSQIDADRMDYLQRDAYYTGVSYGHFDMERILRVMRPREDQIVIKESGMHAV EDYIMSRYQMYWQVYFHPVTRSAEVILTKILHRAKQLHDEGYVFTHAPVHFYSIFEGK LTLEDYVKLDESIILYYFQAWEDEEDAILSDLCRRFINRQLFQYVEFNPNEEMSAYFE LTSLFKEAGIDPSYYLVVDSSSDLPYDFYRPGEEEERLPIHLLTQNGQIKELSRQSAI VESISGKRRTDHKLYYPKDLICDGTKHPEAKMKIRQLLGLT*" /label="ywfO CDS" gene complement(3336782..3338083) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /label="ywfO gene" promotor_-10 complement(3338107..3338126) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3338121) /Source="Nicolas_upshifts" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3338123..3338244) /Source="Nicolas_S_feature" /locus_tag="new_3860876_3860997_c" /HighExp="G180, Paraq, Oxctl, G135, H2O2, G150, C30, LBGstat, LBGexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1456" promotor_-35 complement(3338142..3338144) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3338245..3338469) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391641.1" /db_xref="EnsemblGenomes-Gn:BSU37610" /db_xref="EnsemblGenomes-Tr:CAB15788" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR020880" /db_xref="SubtiList:BG14164" /db_xref="UniProtKB/Swiss-Prot:O32280" /translation="MANEFRVCDDCQATNIKTLLPRLKEVDPDAKVEVGCQSYCGPGR KKSFAFVNNRPLSAPTEDELIDKVKKKIKK*" /label="ywzC CDS" gene complement(3338245..3338469) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /label="ywzC gene" S_feature complement(3338470..3338554) /Source="Nicolas_S_feature" /locus_tag="new_3861223_3861307_c" /HighExp="G180, Paraq, H2O2, G135, LBGexp, dia15, G150, Lbexp, Heat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1457" promotor_-10 complement(3338543..3338562) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3338553) /Source="Nicolas_upshifts" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3338577..3338580) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3338620..3338626 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3338641..3338652 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3338642 /Source="Nicolas_upshifts" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="upshifts" CDS 3338684..3339460 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10629188, 16497325, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629188, 16497325, 22829778; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="prespore-specific transcription regulatory gene" /protein_id="NP_391642.1" /db_xref="EnsemblGenomes-Gn:BSU37620" /db_xref="EnsemblGenomes-Tr:CAB15789" /db_xref="GOA:P39650" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017877" /db_xref="SubtiList:BG10638" /db_xref="UniProtKB/Swiss-Prot:P39650" /translation="MTKQRQDAWSEENDLLLAETVLRHVREGSTQLNAFEEVGDKLNR TSAACGFRWNAVVRHQYEKALQLAKKQRKQRMRALGNGQPAKKRLLYQPPAVDPEIIQ ETAAEEPVKTETPSVENEQPLMSGEHMPFVDESFKEELASLSHLLSPQTPAAAPEMTM NDVIRFLQNYEGNHEQSSALKMENERLKKENQELQNKTEQLEAEVQKLEKDQKTIQED YETLVKIMNRARKLVLFEEDEHASPSFKMDRNGNLEKLAE*" /label="psrF CDS" gene 3338684..3339460 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /label="psrF gene" downshifts 3339446 /Source="Nicolas_upshifts" /id="D1951" /incds=0 /nref=14 /ntot=78 /MaxReadThrough="4.08166" /MaxDrop="4.36214" /score="-5.88286948" /energy="-14.4" /TU="U2958" /idTUdmin="U2958" /TUdmin="-3036" /isTUend="FALSE" /label="downshifts" promotor_-35 3339548..3339555 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3339570..3339589 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3339574..3343800 /Source="Nicolas_S_feature" /locus_tag="new_3862327_3866553" /HighExp="T1.30H, T2.0H, T1.0H, T2.30H, T0.30H, T3.0H, T3.30H, T4.0H, T5.0H, T0.0H" /AntisenseName="pta" /AntisenseCor="-0.61235087907102503" /AntisenseRegPval="-28.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.836" /TUlongSig="NA" /TUlongPSig="NA" /label="S1458" upshifts 3339574 /Source="Nicolas_upshifts" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3339604..3340494) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative toxic excess metabolite exporter" /protein_id="NP_391643.1" /db_xref="EnsemblGenomes-Gn:BSU37630" /db_xref="EnsemblGenomes-Tr:CAB15790" /db_xref="GOA:P39649" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004779" /db_xref="SubtiList:BG10637" /db_xref="UniProtKB/Swiss-Prot:P39649" /translation="MKGNIYSLFVLIAAFFWGTTGTVQALAPESATPLAFGAFRLLIG GSAMLLAVWISRELHVKNWAWPLVFLAAVCMACYQPLFFTAVKETGIAVGTVIAIGSA PIIAGTLEWAVLKKRPRNSWWIATVLALAGCWLLFSDSSNVRIDVAGVLMALGAGASF AGYTLISKAMMKTQPPRATSAVVFMISAILLTPLLWQLDISWILTPRGLGTSLYIGLI ATCAAYFLFAKGLTGVPASAAVTLSLAEPLTASLLGVFFIGEMLSPSSWLGIALMMLG LLVISAAPRKQKTAEAAHMS*" /label="ywfM CDS" gene complement(3339604..3340494) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /label="ywfM gene" promotor_no_box complement(3340494..3340594) /Source="Nicolas_upshift_promotors" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3340534) /Source="Nicolas_upshifts" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3340662..3341507) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /function="4: Biosynthesis of cofactors, prosthetic groups, and carriers" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidotransferase of the octanoyl moiety from octanoyl-GcvH to the E2 subunit of pyruvate dehydrogenase" /protein_id="NP_391644.1" /db_xref="EnsemblGenomes-Gn:BSU37640" /db_xref="EnsemblGenomes-Tr:CAB15791" /db_xref="GOA:P39648" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024897" /db_xref="SubtiList:BG10636" /db_xref="UniProtKB/Swiss-Prot:P39648" /translation="MANQPIDLLMQPKWRVIDQSSLGPLFDAKQSFAMDDTLCMSVGK GVSPATARSWVHHDTIVLGIQDTRLPFLQDGISLLESEGYRVIVRNSGGLAVVLDDGV LNISLIFEDEKKGIDIDKGYEAMVELMRRMLRPYNAKIEAYEIEGSYCPGSYDLSING KKFAGISQRRVRGGVAVQIYLCADKSGSERADLIRRFYQAALKDKQNDKKGVYPEIRP ETMASLSELLQKDISVQDLMFALLTELKALSTHLYSAGLSIDEEMEFEKNLVRMAERN AKVFG*" /label="lipL CDS" gene complement(3340662..3341507) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /label="lipL gene" downshifts complement(3340825) /Source="Nicolas_upshifts" /id="D1952" /incds=1 /nref=4 /ntot=180 /MaxReadThrough="3.21908" /MaxDrop="3.30122" /score="31.9003746" /energy="-18.6" /TU="U2961" /idTUdmin="U2961" /TUdmin="-27" /isTUend="FALSE" /label="downshifts" CDS complement(3341556..3342455) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sulfur assimilation CysL, activatescysJI expression" /protein_id="NP_391645.1" /db_xref="EnsemblGenomes-Gn:BSU37650" /db_xref="EnsemblGenomes-Tr:CAB15792" /db_xref="GOA:P39647" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10635" /db_xref="UniProtKB/Swiss-Prot:P39647" /translation="MYYDVLKTFIAVVEEKNFTKAAEKLMISQPSVSLHIKNLEKEFQ TALLNRSPKHFTTTPTGDILYQRAKQMVFLYEQAKAEIYAHHHYVKGELKIAASFTIG EYILPPLLAQLQKLYPELNLDVMIGNTEEVSERVRMLQADIGLIEGHTNENELEIEPF MEDEMCIAAPNQHPLAGRKEISISDLQNEAWVTREKGSGTREYLDHVLSSNGLRPKSM FTISSNQGVKEAVINGMGLSVLSRSVLRKDLIHREISILHINNFSLKRKLSYIHSPLM ENTKNKEIFITMLKSNYQSQLLK*" /label="cysL CDS" gene complement(3341556..3342455) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /label="cysL gene" promotor_-10 complement(3342498..3342517) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3342501) /Source="Nicolas_upshifts" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3342531..3342538) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3342602) /Source="Nicolas_upshifts" /id="D1953" /incds=0 /nref=222 /ntot=251 /MaxReadThrough="1.96406" /MaxDrop="7.24606" /score="32.3178773" /energy="-17.3" /TU="NA" /idTUdmin="U2962" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3342602..3343573) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /EC_number="2.3.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphotransacetylase" /protein_id="NP_391646.1" /db_xref="EnsemblGenomes-Gn:BSU37660" /db_xref="EnsemblGenomes-Tr:CAB15793" /db_xref="GOA:P39646" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR004614" /db_xref="InterPro:IPR012147" /db_xref="PDB:1TD9" /db_xref="PDB:1XCO" /db_xref="SubtiList:BG10634" /db_xref="UniProtKB/Swiss-Prot:P39646" /translation="MADLFSTVQEKVAGKDVKIVFPEGLDERILEAVSKLAGNKVLNP IVIGNENEIQAKAKELNLTLGGVKIYDPHTYEGMEDLVQAFVERRKGKATEEQARKAL LDENYFGTMLVYKGLADGLVSGAAHSTADTVRPALQIIKTKEGVKKTSGVFIMARGEE QYVFADCAINIAPDSQDLAEIAIESANTAKMFDIEPRVAMLSFSTKGSAKSDETEKVA DAVKIAKEKAPELTLDGEFQFDAAFVPSVAEKKAPDSEIKGDANVFVFPSLEAGNIGY KIAQRLGNFEAVGPILQGLNMPVNDLSRGCNAEDVYNLALITAAQAL*" /label="pta CDS" gene complement(3342602..3343573) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /label="pta gene" promotor_-10 complement(3343608..3343627) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3343633) /Source="Nicolas_upshifts" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3343643..3343647) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3343721..3343732) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3343724) /Source="Nicolas_upshifts" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3343746..3343752) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3343795..3343814 /Source="Nicolas_upshift_promotors" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3343802 /Source="Nicolas_upshifts" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="upshifts" CDS 3343843..3344607 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /EC_number="4.1.-.-" /function="4.3: Heme, porphyrin, and cobalamin" /experiment="publication(s) with functional evidences, PMID:15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-coproporphyrin (coproheme) decarboxylase" /protein_id="NP_391647.3" /db_xref="EnsemblGenomes-Gn:BSU37670" /db_xref="EnsemblGenomes-Tr:CAB15794" /db_xref="GOA:P39645" /db_xref="InterPro:IPR010644" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR031332" /db_xref="SubtiList:BG10633" /db_xref="UniProtKB/Swiss-Prot:P39645" /translation="MSEQQMTNEAAKTLDGWYALHDFRTMDWASWKLLSSDERQSIIH EFTGLLEKWGVAQKEGKGSQTLYSIVGQKADFMLMILRPTMEELNQIELEFNKSRLAE FTIPAYSYVSVVELSNYLASGDGDPYENPHVRARLYPELPESKYVCFYPMDKRRSGND NWYMLSMEERRNLMRSHGLIGRSYAGKVKQIITGSVGFDDYEWGVTLFSDDVLQFKKL VYEMRFDEVSARYGEFGSFFVGNHLSLDTLPQFLYV*" /label="hemQ CDS" gene 3343843..3344607 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /label="hemQ gene" downshifts 3344594 /Source="Nicolas_upshifts" /id="D1954" /incds=0 /nref=155 /ntot=246 /MaxReadThrough="5.49286" /MaxDrop="6.26609" /score="19.319449" /energy="-14.5" /TU="U2964" /idTUdmin="U2959" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(3344614,3344621) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs11" N_region 3344615..3344620 /note="SacI site (GAGCTC)" /created_by="User" /label="IIG_Bs11" S_feature <3344621..3344673 /Source="Nicolas_S_feature" /locus_tag="new_3873771_3874382" /HighExp="Etha, Salt, Gly, Heat, C30, LPhT, HiTm, C90, S8, M/G" /AntisenseName="bacA" /AntisenseCor="9.8443047207874598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1459" CDS complement(3344623..3345861) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15609023, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391655.1" /db_xref="EnsemblGenomes-Gn:BSU37750" /db_xref="EnsemblGenomes-Tr:CAB15802" /db_xref="GOA:P39637" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10625" /db_xref="UniProtKB/Swiss-Prot:P39637" /translation="MNSNQNNDIKTKHHFPLLLALALTMGVFAAGSEELVISPLLPDL AKAFSSDVSVLALSISIYGVMIFIGAPLLVPLGDKYSRELSLLAGLMIFIIGTVICAL AQNIFFFFLGRALSGLAAGAFVPTAYAVVGDRVPYTYRGKVMGLIVSSWSLALIFGVP LGSFIGGVLHWRWTFWIFALMGVLVVLLILLEMRRHAQHKNSGKEEIEEPAGTFRDAL KVPRVPVYITITFCNMIGFYGMYSFLGTYLQDVFTGGNTAAGLFIMIYGIGFSMSVIT GKIADRIGKMRSLLIALGVISVLLACLPYAPASMFLLIASLFIWGLMQSLTVTLLSTI LSDCSERHRGKVMVFYSLASNLAVTLGSALMGPVYVAYGYAAVGLICAAITVLGFVLS VFAYKKYGKLEQKADQSLSQ*" /label="ywfA CDS" gene complement(3344623..3345861) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /label="ywfA gene" promotor_-10 complement(3345903..3345922) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3345915) /Source="Nicolas_upshifts" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3345934..3345941) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3346071..3347483) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7540694, 8113162, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="basic aminoacid permease" /protein_id="NP_391656.1" /db_xref="EnsemblGenomes-Gn:BSU37760" /db_xref="EnsemblGenomes-Tr:CAB15803" /db_xref="GOA:P39636" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10624" /db_xref="UniProtKB/Swiss-Prot:P39636" /translation="MQNHKNELQRSMKSRHLFMIALGGVIGTGLFLGSGFTISQAGPL GAIAAYIIGGFLMYLVMLCLGELAVAMPVAGSFQAYATKFLGQSTGFMIGWLYWFSWA NTVGLELTSAGILMQRWLPSVPIWIWCLVFGIVIFLINALSVRSFAEMEFWFSSIKVA AIILFIVIGGAAVFGLIDFKGGQETPFLSNFMTDRGLFPNGVLAVMFTLVMVNFSFQG TELVGIAAGESESPEKTLPKSIRNVIWRTLFFFVLAMFVLVAILPYKTAGVIESPFVA VLDQIGIPFSADIMNFVILTAILSVANSGLYAASRMMWSLSSNQMGPSFLTRLTKKGV PMNALLITLGISGCSLLTSVMAAETVYLWCISISGMVTVVAWMSICASQFFFRRRFLA EGGNVNDLEFRTPLYPLVPILGFCLYGCVLISLIFIPDQRIGLYCGVPIIIFCYAYYH LSIKKRINHETIEKKQTEAQ*" /label="rocC CDS" gene complement(3346071..3347483) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /label="rocC gene" downshifts complement(3346078) /Source="Nicolas_upshifts" /id="D1957" /incds=0 /nref=16 /ntot=112 /MaxReadThrough="1.06691" /MaxDrop="5.69562" /score="41.626335" /energy="-15.9" /TU="NA" /idTUdmin="U2971" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3347483..3349183) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8113162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase involved in arginine and ornithine utilization" /protein_id="NP_391657.1" /db_xref="EnsemblGenomes-Gn:BSU37770" /db_xref="EnsemblGenomes-Tr:CAB15804" /db_xref="GOA:P39635" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG10623" /db_xref="UniProtKB/Swiss-Prot:P39635" /translation="MQYTKISHMNPAERVEALTASLVSLSSVNGTVGEGTKADFIKEV ITSYPYFQENPSHVWEQAIPNDPYKRKNIFAFIKGHGESRNTVIYHAHLDTVGIEDFG PLKDIAFDCEKLAEYFSRYEFDQDVQRDAKSGEWMFGRGSVDMQSGIAVHLANLLHFS ENLETLPGNVLFMANPDEESQHSGILASISELNRLKKEKQLHYLAAINTDFITPLYDG DQTRYIYTGAAGKLLPCFYIYGREVHVGDTLAGIDPNFISSEITSRLHNNIHLAEKVE GELVLPPSCLYQRDNKESYNVQTAVSTSLYFNCFIYERTAKEMMDLLIEVTEEACRET EQKLSDYYEEYVKRANLPKKHLSWGIQVYSLEQYLEKLRNRGIDPEQCIEQTFKANEH LELRMRCFQAIEELQKLDPDQGAKVILFYAPPYLPHNYLKEDSARDQLLQHVIKEAAD KTAESTGETFVFKKFFPYLADGSFLSLHETDGEIDSFIRNFPGWNMIGTIPFKDIRKL NIPSINMGVYGKDGHKWTERVYKPYTFHVLPLLIQQTTVHLLQSYRMTITAKEPKGEG *" /label="rocB CDS" gene complement(3347483..3349183) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /label="rocB gene" misc_feature complement(3348152..3348168) /Source="Nicolas_upshift_promotors" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3348164) /Source="Nicolas_upshifts" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3349257..3350804) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11418582, 12634342, 8113162, 9383188, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-1-pyrroline-5 carboxylate dehydrogenase" /protein_id="NP_391658.1" /db_xref="EnsemblGenomes-Gn:BSU37780" /db_xref="EnsemblGenomes-Tr:CAB15805" /db_xref="GOA:P39634" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10622" /db_xref="UniProtKB/Swiss-Prot:P39634" /translation="MTVTYAHEPFTDFTEAKNKTAFGESLAFVNTQLGKHYPLVINGE KIETDRKIISINPANKEEIIGYASTADQELAEKAMQAALQAFDSWKKQRPEHRANILF KAAAILRRRKHEFSSYLVKEAGKPWKEADADTAEAIDFLEFYARQMLKLKEGAPVKSR AGEVNQYHYEALGVGIVISPFNFPLAIMAGTAVAAIVTGNTILLKPADAAPVVAAKFV EVMEEAGLPNGVLNYIPGDGAEIGDFLVEHPKTRFVSFTGSRAVGCRIYERAAKVQPG QKWLKRVIAEMGGKDTVLVDKDADLDLAASSIVYSAFGYSGQKCSAGSRAVIHQDVYD EVVEKAVALTKTLTVGNPEDPDTYMGPVIHEASYNKVMKYIEIGKSEGKLLAGGEGDD SKGYFIQPTIFADVDENARLMQEEIFGPVVAICKARDFDHMLEIANNTEYGLTGALLT KNRAHIERAREDFHVGNLYFNRGCTGAIVGYQPFGGFNMSGTDSKAGGPDYLILHMQA KTTSEAF*" /label="rocA CDS" gene complement(3349257..3350804) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /label="rocA gene" downshifts complement(3349264) /Source="Nicolas_upshifts" /id="D1958" /incds=0 /nref=4 /ntot=50 /MaxReadThrough="5.60027" /MaxDrop="3.5628" /score="41.626335" /energy="-15.9" /TU="U2971,U2972" /idTUdmin="U2973" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3350848) /Source="Nicolas_upshifts" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3350850..3351030) /Source="Nicolas_S_feature" /locus_tag="new_3880559_3880739_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1460" misc_feature complement(3350851..3350869) /Source="Nicolas_upshift_promotors" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3351031..3352305) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate dehydrogenase" /protein_id="NP_391659.2" /db_xref="EnsemblGenomes-Gn:BSU37790" /db_xref="EnsemblGenomes-Tr:CAB15806" /db_xref="GOA:P39633" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K92" /db_xref="SubtiList:BG10621" /db_xref="UniProtKB/Swiss-Prot:P39633" /translation="MSAKQVSKDEEKEALNLFLSTQTIIKEALRKLGYPGDMYELMKE PQRMLTVRIPVKMDNGSVKVFTGYRSQHNDAVGPTKGGVRFHPEVNEEEVKALSIWMT LKCGIANLPYGGGKGGIICDPRTMSFGELERLSRGYVRAISQIVGPTKDIPAPDVYTN SQIMAWMMDEYSRLREFDSPGFITGKPLVLGGSQGRETATAQGVTICIEEAVKKKGIK LQNARIIIQGFGNAGSFLAKFMHDAGAKVIGISDANGGLYNPDGLDIPYLLDKRDSFG MVTNLFTDVITNEELLEKDCDILVPAAISNQITAKNAHNIQASIVVEAANGPTTIDAT KILNERGVLLVPDILASAGGVTVSYFEWVQNNQGYYWSEEEVAEKLRSVMVSSFETIY QTAATHKVDMRLAAYMTGIRKSAEASRFRGWV*" /label="rocG CDS" gene complement(3351031..3352305) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /label="rocG gene" S_feature complement(3352306..3352388) /Source="Nicolas_S_feature" /locus_tag="new_3882015_3882097_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.83780600000000005" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1461" upshifts complement(3352388) /Source="Nicolas_upshifts" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3352401..3352419) /Source="Nicolas_upshift_promotors" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3352481) /Source="Nicolas_upshifts" /id="D1959" /incds=0 /nref=9 /ntot=144 /MaxReadThrough="4.82066" /MaxDrop="4.13762" /score="22.6949864" /energy="-11.4" /TU="U2973" /idTUdmin="U2977" /TUdmin=369 /isTUend="FALSE" /label="downshifts" CDS complement(3352482..3352946) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /experiment="publication(s) with functional evidences, PMID:15187182, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 28751732; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm protein, member of the processed secretome contributing to biofilm hydrophobicity" /protein_id="NP_391660.1" /db_xref="EnsemblGenomes-Gn:BSU37800" /db_xref="EnsemblGenomes-Tr:CAB15807" /db_xref="GOA:P39632" /db_xref="InterPro:IPR034650" /db_xref="PDB:5MKD" /db_xref="SubtiList:BG10620" /db_xref="UniProtKB/Swiss-Prot:P39632" /translation="MLKRTSFVSSLFISSAVLLSILLPSGQAHAQSASIEAKTVNSTK EWTISDIEVTYKPNAVLSLGAVEFQFPDGFHATTRDSVNGRTLKETQILNDGKTVRLP LTLDLLGASEFDLVMVRKTLPRAGTYTIKGDVVNGLGIGSFYAETQLVIDPR*" /label="bslB CDS" gene complement(3352482..3352946) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /label="bslB gene" S_feature complement(3352947..3353057) /Source="Nicolas_S_feature" /locus_tag="new_3882656_3882766_c" /HighExp="C90, S1, S0, MG 150, M9-tran, LPhT, BI, GM 150, Lbtran, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1462" promotor_-10 complement(3353039..3353058) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-10" upshifts complement(3353057) /Source="Nicolas_upshifts" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="upshifts" promotor_-35 complement(3353073..3353080) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-35" downshifts complement(3353268) /Source="Nicolas_upshifts" /id="D1960" /incds=0 /nref=32 /ntot=80 /MaxReadThrough="3.01999" /MaxDrop="4.92444" /score="6.35246869" /energy="-8.4" /TU="U2977" /idTUdmin="U2977" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(3353270..3353725) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /EC_number="5.1.3.13" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25239894; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-deoxyrhamnose-3,5-epimerase (cell surface and spore coat)" /protein_id="YP_054595.1" /db_xref="EnsemblGenomes-Gn:BSU37810" /db_xref="EnsemblGenomes-Tr:CAE01469" /db_xref="GOA:Q7WY56" /db_xref="InterPro:IPR000888" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG14195" /db_xref="UniProtKB/Swiss-Prot:Q7WY56" /translation="MIDGVKVKKLMKHSDDRGFFAELVRDDENLLEHFGQASWSKSYP GVIKAFHYHEKQDDLWFFPTGHAQVVLYDLREDSKTKGETDVYYMGEDNPMLLLIPKG VAHGYRVLGETPLTIIYFTTMSYNPDQPDEKRIPWDDETIGFNWNTEFR*" /label="spsL CDS" gene complement(3353270..3353725) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /label="spsL gene" misc_feature 3353360..3353379 /Source="Nicolas_upshift_promotors" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3353368 /Source="Nicolas_upshifts" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3353718..3354569) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /EC_number="1.1.1.133" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-dehydrorhamnose reductase" /protein_id="NP_391661.3" /db_xref="EnsemblGenomes-Gn:BSU37820" /db_xref="EnsemblGenomes-Tr:CAB15808" /db_xref="GOA:P39631" /db_xref="InterPro:IPR005913" /db_xref="InterPro:IPR029903" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10619" /db_xref="UniProtKB/Swiss-Prot:P39631" /translation="MTKVLVTGAGGQLGLELCRQLKQAGYEVIALTKKMMNIADQRSV RHSFGHYQPDIVVNSAAFTSVDQCEKELDKAYLINGIGAYYTALESTRIGAQYVHIST DYVFNGKGTQPYREDDPLDPKTIYGKSKRLGEELIRLTTKDSTIIRTSWVYGHGGSNF VETMLKLAETKQELRVVSDQIGSPTYTKDLAEAVIKLFSHPPGIYHVSNSGICSWYEF ATAIMEESGLETAILSVTTEEYGNKTPRPAYSVLSHRAIEEAGIRPRHWREALREYLQ ERSSACD*" /label="spsK CDS" gene complement(3353718..3354569) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /label="spsK gene" CDS complement(3354583..3355530) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /EC_number="4.2.1.46" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dTDP-glucose 4,6-dehydratase" /protein_id="NP_391662.1" /db_xref="EnsemblGenomes-Gn:BSU37830" /db_xref="EnsemblGenomes-Tr:CAB15809" /db_xref="GOA:P39630" /db_xref="InterPro:IPR005888" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10618" /db_xref="UniProtKB/Swiss-Prot:P39630" /translation="MAKSYLITGGAGFIGLTFTKLMLRETDARITVLDKLTYASHPEE MEKLKQNSRFRFVKGDISVQEDIDRAFDETYDGVIHFAAESHVDRSISQAEPFITTNV MGTYRLAEAVLKGKAKKLIHISTDEVYGDLKADDPAFTETTPLSPNNPYSASKASSDL LVLSYVKTHKLPAIITRCSNNYGPYQHSEKMIPTIIRHAKQGLPVPLYGDGLQIRDWL FAEDHCRAIKLILEKGTDGEVYNIGGGNERTNKELASVILKHLGCEELFAHVEDRKGH DRRYAINASKLKNELGWRQEVTFEEGIARTIQWYTDNDR*" /label="spsJ CDS" gene complement(3354583..3355530) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /label="spsJ gene" CDS complement(3355530..3356270) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /EC_number="2.7.7.24" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate thymidylyltransferase" /protein_id="NP_391663.1" /db_xref="EnsemblGenomes-Gn:BSU37840" /db_xref="EnsemblGenomes-Tr:CAB15810" /db_xref="GOA:P39629" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005907" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10617" /db_xref="UniProtKB/Swiss-Prot:P39629" /translation="MKGVILAGGNGSRLMPLTKAVNKHLLPVGPYPMIYWSIMKLQEA GIKDILLISQKEHMPQFYKLLGNGEELGVTITYQVQPAASGISDGLSYAKRFTKKESF ILLLGDNIFEDSLKPYTERFEQQGKGAKVLLKEVDDPERFGIAEIDEKNKRIRSIIEK PEQPPTNLCVTGIYMYDAEVFSYIEQISPSKRGELEITDVNNLYIENSQLTYDVLSGW WVDAGTHESLYLASQLVHQALRKGQDEK*" /label="spsI CDS" gene complement(3355530..3356270) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /label="spsI gene" promotor_-35 3356288..3356293 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3356294 /Source="Nicolas_upshifts" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3356295..3357314) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391664.1" /db_xref="EnsemblGenomes-Gn:BSU37850" /db_xref="EnsemblGenomes-Tr:CAB15811" /db_xref="GOA:P39627" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10615" /db_xref="UniProtKB/Swiss-Prot:P39627" /translation="MHVGIFADGGYEKGMGHVVRMKRLAEGLKQRCLITFYTNQDSEA FLHEEHWQVIVKPELQQHEFILREIKSKKLDLLLFDILGAPAELLKKIKTETDAKIVL FEEKNGKSIQYSDAVINGIYGDIRSRVYVQGNTRIYEGPDYLILHPAFQAAREDYTLK KDCRNILVALGGSDPKQLIFKVLAAADQVPDIKDKNMMFVMGSASPHQEAVRRRIEKK PQYKMIEQTNDMAGLMKQADAAIVAGGISLYEAICIGVPCLVLSQVEHQTATAKTFAD QGAALDLGLGELVPDETLIYQMSRIMSSYPLRLSLHKGGRPLVDGKGIIRVTAILQDL YEQEI*" /label="spsG CDS" gene complement(3356295..3357314) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /label="spsG gene" promotor_-10 3356308..3356326 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3357178..3357187 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3357200..3357215 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3357211 /Source="Nicolas_upshifts" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3357317..3358039) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391665.2" /db_xref="EnsemblGenomes-Gn:BSU37860" /db_xref="EnsemblGenomes-Tr:CAB15812" /db_xref="InterPro:IPR003329" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10614" /db_xref="UniProtKB/Swiss-Prot:P39626" /translation="MNDILFIIQARMGSTRLPGKVLRPLGSNRLLDILVHRVRQSAFY QKDRDNLVIATSDKETDDILEAHCIKQGFRVFRGSEERVLDRFVKVIEAVKPSVIIRL TGDNPFVDPELLDVMIQAHFDQGSDYTYILNAPLGICGEVVNANLLIDISRIQALEDQ YQEHVTLYIRNHPALYRVQFLEAPERFRAPQYRLTIDTKEDYESIKALYQKAGERPDV SASELITLLNRNPDAATEREAD*" /label="spsF CDS" gene complement(3357317..3358039) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /label="spsF gene" CDS complement(3358032..3359153) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /EC_number="2.5.-.-" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12597896, 15774001; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoenolpyruvate-sugar pyruvyltransferase" /protein_id="NP_391666.1" /db_xref="EnsemblGenomes-Gn:BSU37870" /db_xref="EnsemblGenomes-Tr:CAB15813" /db_xref="GOA:P39625" /db_xref="InterPro:IPR006190" /db_xref="InterPro:IPR013132" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR036732" /db_xref="PDB:1VLI" /db_xref="SubtiList:BG10613" /db_xref="UniProtKB/Swiss-Prot:P39625" /translation="MAAFQIANKTVGKDAPVFIIAEAGINHDGKLDQAFALIDAAAEA GADAVKFQMFQADRMYQKDPGLYKTAAGKDVSIFSLVQSMEMPAEWILPLLDYCREKQ VIFLSTVCDEGSADLLQSTSPSAFKIASYEINHLPLLKYVARLNRPMIFSTAGAEISD VHEAWRTIRAEGNNQIAIMHCVAKYPAPPEYSNLSVIPMLAAAFPEAVIGFSDHSEHP TEAPCAAVRLGAKLIEKHFTIDKNLPGADHSFALNPDELKEMVDGIRKTEAELKQGIT KPVSEKLLGSSYKTTTAIEGEIRNFAYRGIFTTAPIQKGEAFSEDNIAVLRPGQKPQG LHPRFFELLTSGVRAVRDIPADTGIVWDDILLKDSPFHE*" /label="spsE CDS" gene complement(3358032..3359153) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /label="spsE gene" CDS complement(3359153..3360022) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative TDP-glycosamine N-acetyltransferase" /protein_id="NP_391667.1" /db_xref="EnsemblGenomes-Gn:BSU37880" /db_xref="EnsemblGenomes-Tr:CAB15814" /db_xref="GOA:P39624" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10612" /db_xref="UniProtKB/Swiss-Prot:P39624" /translation="MYTVKENVSKEAIEEFLQSRKLTLDVPYQFSLGLFENSRLQGVL LYEDSLWESKVLQKKVMNVKLLAANSTGQLKRLFEAFYTVRQMDETDFIFVRVPAEDI GAAHVIQQQPSSYFVGSLLKLAMPPSFYDKTPPFFELGPPEPGDTEAICELARDSFTK SRYFQDPHLSRDAANEIFQEWTRNNLNGRAAVNIVAKHNGEVIGYLQGLSRDDECILD LMAVKPGFEGKRIAFHLLANLIEQPETQKHRTVTAGTQLHNVRAIRLYERMGFTAEQS YYYYHIWPGKEAK*" /label="spsD CDS" gene complement(3359153..3360022) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /label="spsD gene" CDS complement(3360023..3361192) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /EC_number="2.6.1.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14602648; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glutamine-dependent sugar transaminase" /protein_id="NP_391668.1" /db_xref="EnsemblGenomes-Gn:BSU37890" /db_xref="EnsemblGenomes-Tr:CAB15815" /db_xref="GOA:P39623" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10611" /db_xref="UniProtKB/Swiss-Prot:P39623" /translation="MVQKRNHFLPYSLPLIGKEEIQEVTETLESGWLSKGPKVQQFEK EFAAFVGAKHAVAVNSCTAALFLALKAKGIGPGDEVITSPLTFSSTANTIIHTGATPV FADIDENTLNIDPVKLEAAVTPRTKAVVPVHFGGQSCDMDAILAVAQNHGLFVLEDAA HAVYTTYKQRMIGSIGDATAFSFYATKNLATGEGGMLTTDDEELADKIRVLSLHGMSK AAWNRYSSNGSWYYEVESPGYKMNMFDLQAALGLHQLKRLDDMQKRREEIAGRYQTAF QQIPGLITPFVHDDGRHAWHLYVLQVDEKKAGVTRSEMITALKDEYNIGTSVHFIPVH IHPYYQKQFGYKEADFPNAMNYYKRTLSLPLYPSMSDDDVDDVIEAVRDIVKGAD*" /label="spsC CDS" gene complement(3360023..3361192) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /label="spsC gene" CDS complement(3361213..3362637) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22611084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP glycosyl/glycerophosphate transferase or transport" /protein_id="NP_391669.2" /db_xref="EnsemblGenomes-Gn:BSU37900" /db_xref="EnsemblGenomes-Tr:CAB15816" /db_xref="GOA:P39622" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10610" /db_xref="UniProtKB/Swiss-Prot:P39622" /translation="MSAYLSNYWVLYRKYVELFDKLRYKGIPLGLISNFYQYISPELR VMMEEEPELFGSVDQHIDEGQIQPFFEERIQNIVKTNDEPVKGKVILHFDYLRFSNEN YYQFDPEKTAVLARWSLPHYCDLPVISKREIADSCQKGDSKQYLETACSLLAPYDDHP AFGDQAFRDRLFKDIPLFIEAIDTVDALFEQEKISAVIVGTAEDIYSRVLALMCQRKG AVSICLQHGALMGDEAFIPVFTTYQAVFGAYEAEWFIRKGCKPEQILVTGHPRFDQIF NRTPMDMSIFYRKLAFQPTKKIVLIATQPFSEDFYSGVLQGLSDQKQLQIIIKPHPWE IGKNKLDLYHEAAKKHQACRVIKKELELYDLLPYVDAAVTQTSTVGLEAMLFQKPVLI GKSSGNRSYPYYESLGDFMFDQPDELAHTLVEVLRSPDVHQKAEEARLAFIAANYPVA ESTNALFAELKAKTGVDYRREDTE*" /label="spsB CDS" gene complement(3361213..3362637) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /label="spsB gene" CDS complement(3362642..3363412) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10350455, 11042447, 11733986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10350455, 11042447, 11733986; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat dTDP-glycosyltransferase" /protein_id="NP_391670.1" /db_xref="EnsemblGenomes-Gn:BSU37910" /db_xref="EnsemblGenomes-Tr:CAB15817" /db_xref="GOA:P39621" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PDB:1H7L" /db_xref="PDB:1H7Q" /db_xref="PDB:1QG8" /db_xref="PDB:1QGQ" /db_xref="PDB:1QGS" /db_xref="SubtiList:BG10609" /db_xref="UniProtKB/Swiss-Prot:P39621" /translation="MPKVSVIMTSYNKSDYVAKSISSILSQTFSDFELFIMDDNSNEE TLNVIRPFLNDNRVRFYQSDISGVKERTEKTRYAALINQAIEMAEGEYITYATDDNIY MPDRLLKMVRELDTHPEKAVIYSASKTYHLNENRDIVKETVRPAAQVTWNAPCAIDHC SVMHRYSVLEKVKEKFGSYWDESPAFYRIGDARFFWRVNHFYPFYPLDEELDLNYITD QSIHFQLFELEKNEFVRNLPPQRNCRELRESLKKLGMG*" /label="spsA CDS" gene complement(3362642..3363412) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /label="spsA gene" promotor_-10 complement(3363447..3363466) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3363461) /Source="Nicolas_upshifts" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3363480..3363489) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3363580..3363585 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3363601..3363619 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3363603..3363731 /Source="Nicolas_S_feature" /locus_tag="new_3893312_3893440" /HighExp="S5, S4, S3, S7, B36, S8, S6, B60, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1463" upshifts 3363603 /Source="Nicolas_upshifts" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="upshifts" CDS 3363732..3364277 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12644503, 15317760, 16936016, 16936016, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12644503, 15317760, 16936016, 16936016, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391671.1" /db_xref="EnsemblGenomes-Gn:BSU37920" /db_xref="EnsemblGenomes-Tr:CAB15818" /db_xref="GOA:P39620" /db_xref="InterPro:IPR014099" /db_xref="SubtiList:BG10608" /db_xref="UniProtKB/Swiss-Prot:P39620" /translation="MKPKKNQYQQMQAFDNMQGYQPQFGANPYPQQGQGSQMQTMGMQ PMMPMQQGQQGQQGQQGFGFPGQQQGGGFQIPSGPTPSGPGQSVPGMLPVEESYIENI LRLNRGKTATIYMTFENSKEWGSKIFRGVIEAAGRDHIIISDPKSGTRYLLLTIYLDY ITFDEEIAYTYPYSMASYSPR*" /label="gerQ CDS" gene 3363732..3364277 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /label="gerQ gene" downshifts 3364263 /Source="Nicolas_upshifts" /id="D1961" /incds=0 /nref=60 /ntot=77 /MaxReadThrough="1.98659" /MaxDrop="7.96105" /score="16.9179802" /energy="-11.7" /TU="NA" /idTUdmin="U2978" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3364321..3364692) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15919996, 21810204; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391672.2" /db_xref="EnsemblGenomes-Gn:BSU37930" /db_xref="EnsemblGenomes-Tr:CAB15819" /db_xref="GOA:P39619" /db_xref="InterPro:IPR006696" /db_xref="SubtiList:BG10607" /db_xref="UniProtKB/Swiss-Prot:P39619" /translation="MKVFIILGAINALLAVGLGAFGAHGLEGKIPDKYLQVWHTGVQY HMYHALGLFVVAFLADKLSGIGSVTTAGWLMFAGIVLFSGSLYILSVTQISILGAITP LGGVAFIISWIMIVVAAVKYL*" /label="ywdK CDS" gene complement(3364321..3364692) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /label="ywdK gene" downshifts complement(3364339) /Source="Nicolas_upshifts" /id="D1962" /incds=0 /nref=134 /ntot=227 /MaxReadThrough="3.65585" /MaxDrop="4.84049" /score="15.105437" /energy="-11.7" /TU="NA" /idTUdmin="U2979" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3364754..3366076) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine/pyrimidine permease" /protein_id="NP_391673.2" /db_xref="EnsemblGenomes-Gn:BSU37940" /db_xref="EnsemblGenomes-Tr:CAB15820" /db_xref="GOA:P39618" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="SubtiList:BG10606" /db_xref="UniProtKB/Swiss-Prot:P39618" /translation="MKLVLGALQWTAFIIAAAIVVPVAVAQSFHLDHSDSARLIQSTF FVLGIAAVIQCLKGHRLPINESPAGLWWGVYTIYAGLTGTVFATYGDTLRGLQGALLV SAVCFFLLSVFKVIDRLAKLFTPVVTGVYLLLLVMQLSQPIIKGILGIGYRQDGVDGL VFGLALVVIAAAFIMTNSNIMFFKQYSILLALFGGWVLFAAAGAAKPIEMPDRLFQLP SLFPFGTPLFNSGLIITSIFITILLIVNMLASMKVVDIAMKKFSKQPDGKHHERHAGF AASFSHLLSGLTGAIAPVPISGAAGFIETTKMPSKKPFMLGSILVIVISVIPFFMNTF ASLPSPVGFAVNFVVFSAMGGLAFAEFDSYEKEESKRVRSIIGISLLTGVGIMFVPET ALKGLHPVFISLLSNGLVLGTLAAIAADQFQLWRRRKSDNLVSTENKH*" /label="ywdJ CDS" gene complement(3364754..3366076) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /label="ywdJ gene" CDS complement(3366096..3366413) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391674.3" /db_xref="EnsemblGenomes-Gn:BSU37950" /db_xref="EnsemblGenomes-Tr:CAB15821" /db_xref="InterPro:IPR035218" /db_xref="SubtiList:BG10605" /db_xref="UniProtKB/Swiss-Prot:P39617" /translation="MNIHISALIQKMEEELKKAKTAERDEELKRYVAVVRSLCDVVLD QPENASAPRIQPSVTPSPAAPPSTDQLMMEKMMGSAGLNKYRKQEKEKQEEDGNGESL FDF*" /label="ywdI CDS" gene complement(3366096..3366413) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /label="ywdI gene" promotor_-10 complement(3366442..3366461) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3366453) /Source="Nicolas_upshifts" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3366475..3366481) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3366516..3366523 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3366539..3366558 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3366542 /Source="Nicolas_upshifts" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="upshifts" CDS 3366581..3367951 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391675.2" /db_xref="EnsemblGenomes-Gn:BSU37960" /db_xref="EnsemblGenomes-Tr:CAB15822" /db_xref="GOA:P39616" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10604" /db_xref="UniProtKB/Swiss-Prot:P39616" /translation="MNSIPSIISKHKAYFAAGHTRPLESRLNILRKLKQAVRTHEADL IAALYQDLHKSEQEAYSTEIGIVLEEISFVMKRLRKWSKPKRVKTPLTHLGSKSIIIP EPYGTVLVIAPWNYPLQLALSPLIGAIAAGNTVVLKPSEYTPAVSAILSKLISSVFPT DYVAMAEGGPDVSTALLQQPFDYIFFTGSVAVGKIVMEAAAKQLIPVTLELGGKSPCI VHKDADIQLAAKRIVFGKFTNAGQTCIAPDYLFVHEDIKTKLTEEMKRAIREFYGPQP ERNPQYGKIVSERHYQRLLSFLNDGIPLTGGQSDPNHHKIAPTILEQVRDDSPVMQEE IFGPILPLFTYRNIGEVIEKVQSRPKPLALYLFTTNKEIERAVLGNLSFGGGCVNDTL MHVATPYLPFGGVGESGIGSYHGFDSFNTFTHKKSVVKQTNRFDFAFRYPSSKNGLRM IRKILK*" /label="ywdH CDS" gene 3366581..3367951 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /label="ywdH gene" CDS complement(3367976..3368653) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /EC_number="3.2.2.27" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1902430, 9776748, 10080896, 21542855, 22056936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1902430, 9776748, 10080896, 21542855, 22056936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil-DNA glycosylase" /protein_id="NP_391676.1" /db_xref="EnsemblGenomes-Gn:BSU37970" /db_xref="EnsemblGenomes-Tr:CAB15823" /db_xref="GOA:P39615" /db_xref="InterPro:IPR002043" /db_xref="InterPro:IPR005122" /db_xref="InterPro:IPR018085" /db_xref="InterPro:IPR036895" /db_xref="PDB:3ZOQ" /db_xref="PDB:3ZOR" /db_xref="SubtiList:BG10603" /db_xref="UniProtKB/Swiss-Prot:P39615" /translation="MKQLLQDSWWNQLKEEFEKPYYQELREMLKREYAEQTIYPDSRD IFNALHYTSYDDVKVVILGQDPYHGPGQAQGLSFSVKPGVKQPPSLKNIFLELQQDIG CSIPNHGSLVSWAKQGVLLLNTVLTVRRGQANSHKGKGWERLTDRIIDVLSERERPVI FILWGRHAQMKKERIDTSKHFIIESTHPSPFSARNGFFGSRPFSRANAYLEKMGEAPI DWCIKDL*" /label="ung CDS" gene complement(3367976..3368653) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /label="ung gene" downshifts complement(3367990) /Source="Nicolas_upshifts" /id="D1963" /incds=0 /nref=66 /ntot=224 /MaxReadThrough="2.25259" /MaxDrop="4.72154" /score="26.8023311" /energy="-9.1" /TU="NA" /idTUdmin="U2982" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3368480..3368499) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3368496) /Source="Nicolas_upshifts" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3368515..3368520) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3368667..3369473) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /EC_number="2.4.-.-" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9334165; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391677.1" /db_xref="EnsemblGenomes-Gn:BSU37980" /db_xref="EnsemblGenomes-Tr:CAB15824" /db_xref="GOA:P39614" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10602" /db_xref="UniProtKB/Swiss-Prot:P39614" /translation="MKISIVIVTYNRIPALCELLESISRQTLMPYEIIIVNDAGESVV PVKALYPELPIAVINLEKNSGHVAARNAGVKEASGDCIMLCDDDDFFTPGHIEKMAKE IETADFVHSDAEIVSFEEKNGTRYPVSRKLFAYTADYEDMRVFSTYVPSGSMYRRFLH DEIGYFDADVHNYWDWDFYLRAAKDYRVKRVPCASVIYAFSDAGDNQSADLGAKRKQY LDRLSEKHGLGELPTKNFAVLLEEPEMKRREAKSEMVWDGEPVYSRLHRS*" /label="ywdF CDS" gene complement(3368667..3369473) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /label="ywdF gene" promotor_-10 complement(3368966..3368984) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3368980) /Source="Nicolas_upshifts" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3368999..3369005) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3369502..3369521) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3369508) /Source="Nicolas_upshifts" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3369537..3369544) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3369563..3370096) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391678.1" /db_xref="EnsemblGenomes-Gn:BSU37990" /db_xref="EnsemblGenomes-Tr:CAB15825" /db_xref="GOA:P39613" /db_xref="SubtiList:BG10601" /db_xref="UniProtKB/Swiss-Prot:P39613" /translation="MRISSCLYGFVAHGAVFLFTGGCMLLAMAASLPFVFLLDRLPDV VFTAGAILTLLCSYAYVWFWAVRFAYNQKMRLFEVQLGSFVLLALMISLFLLDGSSMK DIMMNWDDAGCAFVPPAFTFLCLSYALVLLPVYQSKLWRLILPNGVRMKDIFHVFGDL MLIMVLLIGATLLFLSL*" /label="ywdE CDS" gene complement(3369563..3370096) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /label="ywdE gene" CDS complement(3370144..3370779) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391679.2" /db_xref="EnsemblGenomes-Gn:BSU38000" /db_xref="EnsemblGenomes-Tr:CAB15826" /db_xref="GOA:P39612" /db_xref="SubtiList:BG10600" /db_xref="UniProtKB/Swiss-Prot:P39612" /translation="MDKETYVSEIKSGLKGLPEGEAMIEEIESHIEHHLFRSFQEGKS EEEAMQTLLQAFGTPTDIVSSFKKIQPVTFRAFLMFHLFCNSALFAVGIAITIMHVWL ESPFVQAVWKGISVSVWLILAAYMIYWVLIGYQGVKEFGKRGEKLVLHTILISMVPNV IFMLVFLFNVIPAALFQSLLTPWFVGTCAFATLLFPLFGRMGCYIGRRQLV*" /label="ywdD CDS" gene complement(3370144..3370779) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /label="ywdD gene" CDS complement(3370772..3371110) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator, PadR family" /protein_id="YP_003097793.1" /db_xref="EnsemblGenomes-Gn:BSU38018" /db_xref="EnsemblGenomes-Tr:CAX52706" /db_xref="GOA:C0H3S6" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3S6" /translation="MLNRELVKGSTVILVLTLLNERPMYGYELVKEMGSRSGNELQMK EGTLYPSLHKLERQGYISSYWEKQEKGPDRKYYRITDEGKEVLAERTKEWSVFSAMMD RILKWSGQNG*" /label="ywzG CDS" gene complement(3370772..3371110) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /label="ywzG gene" promotor_-10 complement(3371132..3371151) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3371143) /Source="Nicolas_upshifts" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3371166..3371173) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3371194..3371197 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3371212..3371231 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3371212 /Source="Nicolas_upshifts" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="upshifts" CDS 3371254..3372069 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /EC_number="2.7.1.35" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14973012, 17012797" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14973012, 17012797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyridoxine, pyridoxal, and pyridoxamine kinase" /protein_id="NP_391681.1" /db_xref="EnsemblGenomes-Gn:BSU38020" /db_xref="EnsemblGenomes-Tr:CAB15828" /db_xref="GOA:P39610" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="PDB:2I5B" /db_xref="SubtiList:BG10598" /db_xref="UniProtKB/Swiss-Prot:P39610" /translation="MSMHKALTIAGSDSSGGAGIQADLKTFQEKNVYGMTALTVIVAM DPNNSWNHQVFPIDTDTIRAQLATITDGIGVDAMKTGMLPTVDIIELAAKTIKEKQLK NVVIDPVMVCKGANEVLYPEHAQALREQLAPLATVITPNLFEASQLSGMDELKTVDDM IEAAKKIHALGAQYVVITGGGKLKHEKAVDVLYDGETAEVLESEMIDTPYTHGAGCTF SAAVTAELAKGAEVKEAIYAAKEFITAAIKESFPLNQYVGPTKHSALRLNQQS*" /label="pdxK CDS" gene 3371254..3372069 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /label="pdxK gene" downshifts 3372048 /Source="Nicolas_upshifts" /id="D1964" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="2.56759" /MaxDrop="5.39956" /score="22.0760698" /energy="-18.1" /TU="NA" /idTUdmin="U2985" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3372124) /Source="Nicolas_upshifts" /id="D1965" /incds=0 /nref=20 /ntot=111 /MaxReadThrough="0.56945" /MaxDrop="6.81686" /score="39.7901804" /energy="-16.8" /TU="NA" /idTUdmin="U2987" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3372159..3372407) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391682.1" /db_xref="EnsemblGenomes-Gn:BSU38030" /db_xref="EnsemblGenomes-Tr:CAB15829" /db_xref="SubtiList:BG10597" /db_xref="UniProtKB/Swiss-Prot:P39609" /translation="MNIHEQKITPECLEKAANQVEDKREEYKDVLLQLKKMLGGTTPH SETAEILTRAYEQMKEYALFVQSIETFLRKSANNLKIK*" /label="ywdA CDS" gene complement(3372159..3372407) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /label="ywdA gene" downshifts complement(3372179) /Source="Nicolas_upshifts" /id="D1966" /incds=0 /nref=6 /ntot=123 /MaxReadThrough="6.75845" /MaxDrop="3.89221" /score="22.6408081" /energy="-10.8" /TU="U2987,U2988" /idTUdmin="U2986" /TUdmin=11 /isTUend="TRUE" /label="downshifts" upshifts complement(3372425) /Source="Nicolas_upshifts" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3372427..3372500) /Source="Nicolas_S_feature" /locus_tag="new_3902136_3902209_c" /HighExp="G150, Mt0, Diami, Lbexp, dia0, dia5, T0.30H, Oxctl, Etha, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.536, 0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1464" misc_feature complement(3372435..3372441) /Source="Nicolas_upshift_promotors" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3372501..3373940) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /EC_number="3.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3100393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sucrose-6-phosphate hydrolase" /protein_id="NP_391683.2" /db_xref="EnsemblGenomes-Gn:BSU38040" /db_xref="EnsemblGenomes-Tr:CAB15830" /db_xref="GOA:P07819" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR006232" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG10596" /db_xref="UniProtKB/Swiss-Prot:P07819" /translation="MTAHDQELRRRAYEEVEKKEPIANSDPHRQHFHIMPPVGLLNDP NGVIYWKGSYHVFFQWQPFQTGHGAKFWGHYTTQDVVNWKREEIALAPSDWFDKNGCY SGSAVTKDDRLYLFYTGNVRDQDGNRETYQCLAVSDDGLSFEKKGVVARLPEGYTAHF RDPKVWEHEGTWYMVIGAQTENLKGQAVLFASDNLTEWRFLGPITGAGFNGLDDFGYM WECPDLFSLQGSDVLIVSPQGLEADGFRYQNVYQSGYFVGRLDYNKPELKHGEFTELD QGFDFYAPQTLEDDQGRRILFAWMAVPDQDEGSHPTIDCHWIHCMTLPRQLTLSGQKL IQQPLPELKAMRRNEKKIHINMHGSSGALPVEKPERTEILLEDIHTESGFSISIRGTA TFSFHKDEGIVTLERKSFDGKRTEARHCRIKDLHTVHMFLDASSVEIFINNGEEVLSA RYFPFPGNHEVTASATGKSEMNVGIWTLM*" /label="sacA CDS" gene complement(3372501..3373940) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /label="sacA gene" CDS complement(3373937..3375322) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /EC_number="2.7.1.211" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1577686, 3122206, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 3122206, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) sucrose-specificenzyme IIBC component" /protein_id="NP_391684.3" /db_xref="EnsemblGenomes-Gn:BSU38050" /db_xref="EnsemblGenomes-Tr:CAB15831" /db_xref="GOA:P05306" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10595" /db_xref="UniProtKB/Swiss-Prot:P05306" /translation="MDYKETAKRLIELLGGKENIISAAHCATRLRLVMKDESKIDQAQ VEELDGVKGAFSSSGQYQIIFGTGLVNKVFDAFSKEADIEREEHVNHQDAAKEKLNPA ARFAKTLSNIFVPIIPAIVASGLLMGLLGMINAFHWMSKDSALLQLLDMFSSAAFIFL PILIGVSASKEFGSNPYLGAVIGGIMIHPNLLNPWGLAEATPDYMHLFGFDIALLGYQ GTVIPVLLAVYVMSKVEKWTRKVVPHAVDLLVTPFVTVIVTGFVAFIAIGPLGRALGS GITVALTYVYDHAGFVAGLIFGGTYSLIVLTGVHHSFHAIEAGLIADIGKNYLLPIWS MANVAQGGAGLAVFFMAKKAKTKEIALPAAFSAFLGITEPVIFGVNLRYRKPFIAAMI GGALGGAYVVFTHVAANAYGLTGIPMIAIAAPFGFSNLIHYLIGMAIAAVSAFIAAFV MKINEDEERKK*" /label="sacP CDS" gene complement(3373937..3375322) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /label="sacP gene" misc_feature complement(3375341..3375350) /Source="Nicolas_upshift_promotors" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3375355) /Source="Nicolas_upshifts" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3375357..3375421) /Source="Nicolas_S_feature" /locus_tag="new_3905066_3905130_c" /HighExp="Diami, G150, dia5, Mt0, M9-stat, Lbtran, Gly, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1465" promotor_-10 complement(3375400..3375417) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3375421) /Source="Nicolas_upshifts" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3375433..3375440) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3375463..3375482) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3375481) /Source="Nicolas_upshifts" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3375496..3375503) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3375562..3375565 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3375572 /Source="Nicolas_upshifts" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3375580..3375599 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3375624..3376394 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16207915, 16428414, 16850406, 18691156; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite transporter" /protein_id="NP_391685.1" /db_xref="EnsemblGenomes-Gn:BSU38060" /db_xref="EnsemblGenomes-Tr:CAB15832" /db_xref="GOA:P39608" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG10594" /db_xref="UniProtKB/Swiss-Prot:P39608" /translation="METQALQKVEQYALKKQNIFASSKIRYVLRSILASIFIGFGITA ASKTGSYFFMADSPFAFPAAAVTFGAAILMIAYGGGDLFTGNTFYFTYTALRKKISWR DTLYLWMSSYAGNLIGAILFAILISATGLFEEPSVHSFLIHLAEHKMEPPASELFFRG MLCNWLVCLAFFIPMSLKGEGAKLFTMMLFVFCFFISGFEHSIANMCTFAISLLIEHP DTVTLMGAVRNLIPVTLGNLTAGIVMMGWMYYTLNPDQ*" /label="nirC CDS" gene 3375624..3376394 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /label="nirC gene" S_feature 3376395..3377462 /Source="Nicolas_S_feature" /locus_tag="new_3906104_3907171" /HighExp="S0, ferm, M0t45, Lbexp, Mal, dia0, M/G, UNK1, M40t45, BI" /AntisenseName="sacT" /AntisenseCor="-0.34218080984654098" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1466" CDS complement(3376433..3377263) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1577686, 2163394, 8535520, 8702561, 19202299, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 2163394, 8535520, 8702561, 19202299, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator of sacAP expression" /protein_id="NP_391686.1" /db_xref="EnsemblGenomes-Gn:BSU38070" /db_xref="EnsemblGenomes-Tr:CAB15833" /db_xref="GOA:P26212" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="SubtiList:BG10593" /db_xref="UniProtKB/Swiss-Prot:P26212" /translation="MKIYKVLNNNAALIKEDDQEKIVMGPGIAFQKKKNDLIPMNKVE KIFVVRDENEKFKQILQTLPEEHIEIAEDIISYAEGELAAPLSDHIHIALSDHLSFAI ERIQNGLLVQNKLLHEIKALYKKEYEIGLWAIGHVKETLGVSLPEDEAGYIALHIHTA KMDAESMYSALKHTTMIKEMIEKIKQYFNRKVDENSISYQRLVTHLRYAVSRLESNEA LHRMDEEMLYFIQKKYSFAYQCALELAEFLKNEYQLHLPESEAGYITLHVQRLQDLSE *" /label="sacT CDS" gene complement(3376433..3377263) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /label="sacT gene" downshifts complement(3376434) /Source="Nicolas_upshifts" /id="D1967" /incds=0 /nref=49 /ntot=139 /MaxReadThrough="3.34691" /MaxDrop="4.9787" /score="11.2756812" /energy="-8.1" /TU="U2992" /idTUdmin="U2991" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3377289..3377308) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3377295) /Source="Nicolas_upshifts" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3377303..3377605) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391687.2" /db_xref="EnsemblGenomes-Gn:BSU38080" /db_xref="EnsemblGenomes-Tr:CAB15834" /db_xref="SubtiList:BG10592" /db_xref="UniProtKB/Swiss-Prot:P39607" /translation="MKRLLVSLRVWMVFLMNWVTPDRKTAAAAVYSAQRTYQRKAAVQ AAGLVSFYEWRMAVNEEEKQKAKAAALYKRRCLQAFKESPKQERAGPHLYMAVKRR*" /label="ywcI CDS" gene complement(3377303..3377605) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /label="ywcI gene" promotor_-35 complement(3377323..3377330) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3377606..3377744) /Source="Nicolas_S_feature" /locus_tag="new_3907315_3907453_c" /HighExp="T5.0H, M9-stat, S2, S4, T4.0H, S3, T3.30H, LoTm, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.823" /TUlongSig="NA" /TUlongPSig="NA" /label="S1467" misc_feature complement(3377729..3377748) /Source="Nicolas_upshift_promotors" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3377744) /Source="Nicolas_upshifts" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3378059..3378067 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3378078..3378096 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3378079 /Source="Nicolas_upshifts" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="upshifts" CDS 3378135..3380555 /gene="vpr" /locus_tag="BSU_38090" /old_locus_tag="BSU38090" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15205417, 15596354, 16946274, 17666034, 18689487, 25666135" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15205417, 15596354, 16946274, 17666034, 18689487, 25666135; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracellular serine protease" /protein_id="NP_391688.1" /db_xref="EnsemblGenomes-Gn:BSU38090" /db_xref="EnsemblGenomes-Tr:CAB15835" /db_xref="GOA:P29141" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR025965" /db_xref="InterPro:IPR034213" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10591" /db_xref="UniProtKB/Swiss-Prot:P29141" /translation="MKKGIIRFLLVSFVLFFALSTGITGVQAAPASSKTSADLEKAEV FGDIDMTTSKKTTVIVELKEKSLAEAKEAGESQSKSKLKTARTKAKNKAIKAVKNGKV NREYEQVFSGFSMKLPANEIPKLLAVKDVKAVYPNVTYKTDNMKDKDVTISEDAVSPQ MDDSAPYIGANDAWDLGYTGKGIKVAIIDTGVEYNHPDLKKNFGQYKGYDFVDNDYDP KETPTGDPRGEATDHGTHVAGTVAANGTIKGVAPDATLLAYRVLGPGGSGTTENVIAG VERAVQDGADVMNLSLGNSLNNPDWATSTALDWAMSEGVVAVTSNGNSGPNGWTVGSP GTSREAISVGATQLPLNEYAVTFGSYSSAKVMGYNKEDDVKALNNKEVELVEAGIGEA KDFEGKDLTGKVAVVKRGSIAFVDKADNAKKAGAIGMVVYNNLSGEIEANVPGMSVPT IKLSLEDGEKLVSALKAGETKTTFKLTVSKALGEQVADFSSRGPVMDTWMIKPDISAP GVNIVSTIPTHDPDHPYGYGSKQGTSMASPHIAGAVAVIKQAKPKWSVEQIKAAIMNT AVTLKDSDGEVYPHNAQGAGSARIMNAIKADSLVSPGSYSYGTFLKENGNETKNETFT IENQSSIRKSYTLEYSFNGSGISTSGTSRVVIPAHQTGKATAKVKVNTKKTKAGTYEG TVIVREGGKTVAKVPTLLIVKEPDYPRVTSVSVSEGSVQGTYQIETYLPAGAEELAFL VYDSNLDFAGQAGIYKNQDKGYQYFDWDGTINGGTKLPAGEYYLLAYAANKGKSSQVL TEEPFTVE*" /label="vpr CDS" gene 3378135..3380555 /gene="vpr" /locus_tag="BSU_38090" /old_locus_tag="BSU38090" /label="vpr gene" upshifts 3378293 /Source="Nicolas_upshifts" /id="U2994" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.677322677322677" /psig="0.986013986013986" /xcortree=625 /SigmaFactorBS="aaaaacgtcggctgatctggaaaaagccgaggtattcggtga tatcgatatgacgacaagcaaaaaaacAACCGTTATAGTGGAATTAAaagaaaaatcc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3378302..3378321 /Source="Nicolas_upshift_promotors" /id="U2994" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.677322677322677" /psig="0.986013986013986" /xcortree=625 /SigmaFactorBS="aaaaacgtcggctgatctggaaaaagccgaggtattcggtga tatcgatatgacgacaagcaaaaaaacAACCGTTATAGTGGAATTAAaagaaaaatcc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 3380543 /Source="Nicolas_upshifts" /id="D1968" /incds=0 /nref=7 /ntot=104 /MaxReadThrough="0.60305" /MaxDrop="5.33856" /score="26.8487936" /energy="-16.5" /TU="NA" /idTUdmin="U2993" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(3380593..3381594) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913069, 15774866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391689.1" /db_xref="EnsemblGenomes-Gn:BSU38100" /db_xref="EnsemblGenomes-Tr:CAB15836" /db_xref="GOA:P39606" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10590" /db_xref="UniProtKB/Swiss-Prot:P39606" /translation="MVSLSILDQSPVSEGSNAETALQQTVALAQAAEDLGYKRFWVSE HHFSKRLAGSSPEVLISHIAAKTKRIRVGSGGVMLPHYSAYKVAENFRVLEGLTPGRI DLGLGRAPGGMPIASWALNDGGKRNADQYPQQIKELTMYLHDLADDKHRFPNLTAAPH ISTAPDVWLLGSSGESALLAAESGAGYMFAHFINGEGGEGTVRQYKRRFKPSVLGDTP RAAVAVFVLCADTEEKAEELGAVLDFTLLAGEQGIPLEGVPSYEAVRKNTYSPYEQRR IADNRNRMIVGTKEQVKERLLALSNAYETEEIMVVTITHHFEDKLRSYRLLQEAFAD* " /label="ywcH CDS" gene complement(3380593..3381594) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /label="ywcH gene" S_feature complement(3381595..3381756) /Source="Nicolas_S_feature" /locus_tag="new_3911304_3911465_c" /HighExp="Etha, Diami, dia15, LPhT, dia5, H2O2, B60, LBGstat, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1468" CDS complement(3381768..3382517) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /EC_number="1.5.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-containing NADPH-linked nitro/flavin reductase" /protein_id="NP_391690.1" /db_xref="EnsemblGenomes-Gn:BSU38110" /db_xref="EnsemblGenomes-Tr:CAB15837" /db_xref="GOA:P39605" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:3N2S" /db_xref="SubtiList:BG10589" /db_xref="UniProtKB/Swiss-Prot:P39605" /translation="MNNTIETILNHRSIRSFTDQLLTAEEIDTLVKSAQAASTSSYVQ AYSIIGVSDPEKKRELSVLAGNQPYVEKNGHFFVFCADLYRHQQLAEEKGEHISELLE NTEMFMVSLIDAALAAQNMSIAAESMGLGICYIGGIRNELDKVTEVLQTPDHVLPLFG LAVGHPANLSGKKPRLPKQAVYHENTYNVNTDDFRHTMNTYDKTISDYYRERTNGKRE ETWSDQILNFMKQKPRTYLNDYVKEKGFNKN*" /label="nfrAA CDS" gene complement(3381768..3382517) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /label="nfrAA gene" downshifts complement(3381801) /Source="Nicolas_upshifts" /id="D1969" /incds=0 /nref=11 /ntot=191 /MaxReadThrough="5.92216" /MaxDrop="3.39651" /score="17.7447455" /energy="-9.9" /TU="U2995" /idTUdmin="U2996" /TUdmin=770 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3382535..3382554) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3382552) /Source="Nicolas_upshifts" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3382569..3382572) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3382623..3383804) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9622350, 15612918, 15849754, 16850406, 28085152" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 15612918, 15849754, 16850406, 28085152; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycosyltransferase involved in extension of thelateral walls of the cell" /protein_id="NP_391691.1" /db_xref="EnsemblGenomes-Gn:BSU38120" /db_xref="EnsemblGenomes-Tr:CAB15838" /db_xref="GOA:P39604" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10588" /db_xref="UniProtKB/Swiss-Prot:P39604" /translation="MSRYKKQQSPFYQGDLIFIFGVFFIISVVSIYAAGQFGQYGNTD WIQQIVFYLLGAVAITVLLYFDLEQLEKLSLYIFIIGILSLIILKISPESIAPVIKGA KSWFRIGRITIQPSEFMKVGLIMMLASVIGKANPKGVRTLRDDIHLLLKIAGVAVIPV GLILMQDAGTAGICMFIVLVMVFMSGINWKLIAIIAGSGILLISLILLVMINFPDVAK SVGIQDYQIKRVTSWVSASNETQEDSNDSWQVDQAIMAIGSGGILGNGISNLKVYVPE STTDFIFSIIGESFGFIGCAIVVIMFFFLIYRLVVLIDKIHPFNRFASFFCVGYTALI VIHTFQNIGMNIGIMPVTGIPLLFVSYGGSSTLSTLIGFGIVYNASVQLTKYRSYLFN S*" /label="rodA CDS" gene complement(3382623..3383804) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /label="rodA gene" downshifts complement(3382637) /Source="Nicolas_upshifts" /id="D1970" /incds=0 /nref=20 /ntot=124 /MaxReadThrough="3.38052" /MaxDrop="5.67563" /score="31.4805549" /energy="-13.3" /TU="U2996" /idTUdmin="U2996" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(3383805..3383936) /Source="Nicolas_S_feature" /locus_tag="new_3913514_3913645_c" /HighExp="Heat, T0.30H, H2O2, T1.0H, Salt, Paraq, T1.30H, LBGstat, Oxctl, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1469" promotor_-10 complement(3383930..3383945) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-10" upshifts complement(3383936) /Source="Nicolas_upshifts" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="upshifts" promotor_-35 complement(3383957..3383966) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-35" promotor_-35 3384171..3384178 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3384189..3384299 /Source="Nicolas_S_feature" /locus_tag="new_3913898_3914008" /HighExp="M9-stat, T0.30H, T1.30H, T1.0H, T4.0H, T2.30H, T3.30H, T3.0H, T5.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1470" promotor_-10 3384189..3384208 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3384189 /Source="Nicolas_upshifts" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="upshifts" CDS 3384300..3384563 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16159778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159778; Product type f: factor" /codon_start=1 /transl_table=11 /product="holin-like protein required for proper spore morphogenesis and germination" /protein_id="NP_391692.1" /db_xref="EnsemblGenomes-Gn:BSU38130" /db_xref="EnsemblGenomes-Tr:CAB15839" /db_xref="GOA:P39603" /db_xref="InterPro:IPR020185" /db_xref="SubtiList:BG10587" /db_xref="UniProtKB/Swiss-Prot:P39603" /translation="MMDMFFAYLLVASATPLFIWLDNKKVALSAIPPIILMWVFFFFY ATESLSPLGHTLMIILFAVNVIVAHIAAFIIYGLPYLRRKRSS*" /label="ywcE CDS" gene 3384300..3384563 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /label="ywcE gene" downshifts 3384453 /Source="Nicolas_upshifts" /id="D1971" /incds=1 /nref=1 /ntot=99 /MaxReadThrough="6.85004" /MaxDrop="2.5697" /score="27.9247684" /energy="-11.4" /TU="U2997" /idTUdmin="U2997" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3384569 /Source="Nicolas_upshifts" /id="D1972" /incds=0 /nref=7 /ntot=90 /MaxReadThrough="2.04756" /MaxDrop="6.52141" /score="27.9247684" /energy="-11.4" /TU="NA" /idTUdmin="U2997" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(3384606..3384980) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit IV)" /protein_id="NP_391693.1" /db_xref="EnsemblGenomes-Gn:BSU38140" /db_xref="EnsemblGenomes-Tr:CAB15840" /db_xref="GOA:P34959" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014250" /db_xref="SubtiList:BG10586" /db_xref="UniProtKB/Swiss-Prot:P34959" /translation="MANKSAEHSHFPWKHIVGFILSIVLTLLALWVAVYTDLSSSAKL WIIFGFAFIQAALQLLMFMHMTESENGTIQVGNTLFGFFGAIVIVLGSIWIFAAHYHH GDHMDGNPPGGAEHSEHSGHNE*" /label="qoxD CDS" gene complement(3384606..3384980) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /label="qoxD gene" downshifts complement(3384617) /Source="Nicolas_upshifts" /id="D1973" /incds=0 /nref=222 /ntot=267 /MaxReadThrough="2.42368" /MaxDrop="9.0593" /score="21.3154492" /energy="-11.4" /TU="NA" /idTUdmin="U3000" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3384982..3385596) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit III)" /protein_id="NP_391694.1" /db_xref="EnsemblGenomes-Gn:BSU38150" /db_xref="EnsemblGenomes-Tr:CAB15841" /db_xref="GOA:P34958" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR014246" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10585" /db_xref="UniProtKB/Swiss-Prot:P34958" /translation="MEHAEHGNSNAPMEYQSETGRLNILGFWIFLGAEIVLFSTLFAT FFVLKNRTAGGVLPDELFEVNLVMIMTFLLLISSFTCGIAVHEMRRGSLKGVVIWTII TLLLGAGFVGCEINEFVHYVHEGAALSTSAFWSGFFVLLGTHGTHVTIGIFWITGILI QLKKRGLTPQTSSKIFISSLYWHFLDVVWIFIFTGVYLMGLGGL*" /label="qoxC CDS" gene complement(3384982..3385596) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /label="qoxC gene" CDS complement(3385610..3387559) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit I)" /protein_id="NP_391695.1" /db_xref="EnsemblGenomes-Gn:BSU38160" /db_xref="EnsemblGenomes-Tr:CAB15842" /db_xref="GOA:P34956" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014233" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10584" /db_xref="UniProtKB/Swiss-Prot:P34956" /translation="MKFKWDEFFVTGDPLILGAQVSIALSTIAIIFVLTYFKKWKWLW SEWITTVDHKKLGIMYIISAVIMLFRGGVDGLMMRAQLALPNNSFLDSNHYNEIFTTH GTIMIIFMAMPFLIGLINVVVPLQIGARDVAFPYLNNLSFWTFFVGAMLFNISFVIGG SPNAGWTSYMPLASNDMSPGPGENYYLLGLQIAGIGTLMTGINFMVTILKMRTKGMTL MRMPMFTWTTLITMVIIVFAFPVLTVALALLSFDRLFGAHFFTLEAGGMPMLWANLFW IWGHPEVYIVILPAFGIFSEIISSFARKQLFGYKAMVGSIIAISVLSFLVWTHHFFTM GNSASVNSFFSITTMAISIPTGVKIFNWLFTMYKGRISFTTPMLWALAFIPNFVIGGV TGVMLAMAAADYQYHNTYFLVSHFHYVLIAGTVFACFAGFIFWYPKMFGHKLNERIGK WFFWIFMIGFNICFFPQYFLGLQGMPRRIYTYGPNDGWTTLNFISTVGAFMMGVGFLI LCYNIYYSFRYSTREISGDSWGVGRTLDWATSSAIPPHYNFAVLPEVKSQDAFLHMKE EKTELYPESKFKKIHMPSNSGRPFFMSVAFGLAGFGLVFEWYWMGVVGLIGVLLCMVL RSFEYDNGYYISVDEIKETERKISE*" /label="qoxB CDS" gene complement(3385610..3387559) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /label="qoxB gene" misc_feature 3386823..3386842 /Source="Nicolas_upshift_promotors" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3386829 /Source="Nicolas_upshifts" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box 3387253..3387353 /Source="Nicolas_upshift_promotors" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3387313 /Source="Nicolas_upshifts" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3387423 /Source="Nicolas_upshifts" /id="D1974" /incds=1 /nref=1 /ntot=73 /MaxReadThrough="3.07388" /MaxDrop="3.44223" /score="-7.14620582" /energy="-8.1" /TU="U2999" /idTUdmin="U2999" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" CDS complement(3387587..3388552) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 22720735, 26196462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit II)" /protein_id="NP_391696.2" /db_xref="EnsemblGenomes-Gn:BSU38170" /db_xref="EnsemblGenomes-Tr:CAB15843" /db_xref="GOA:P34957" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR006332" /db_xref="InterPro:IPR006333" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR034227" /db_xref="InterPro:IPR036257" /db_xref="SubtiList:BG10583" /db_xref="UniProtKB/Swiss-Prot:P34957" /translation="MIFLFRALKPLLVLALLTVVFVLGGCSNASVLDPKGPVAEQQSD LILLSIGFMLFIVGVVFVLFTIILVKYRDRKGKDNGSYNPEIHGNTFLEVVWTVIPIL IVIALSVPTVQTIYSLEKAPEATKDKEPLVVYATSVDWKWVFSYPEQDIETVNYLNIP VDRPILFKISSADSMASLWIPQLGGQKYAMAGMLMDQYLQADKVGTYEGRNANFTGEH FADQEFDVNAVTEKDFNSWVKKTQNEAPKLTKEKYDELMLPENVDELTFSSTHLKYVD HGQDAEYAMEARKRLGYQAVSPHSKTDPFENVKKNEFKKSDDTEE*" /label="qoxA CDS" gene complement(3387587..3388552) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /label="qoxA gene" S_feature complement(3388553..3388621) /Source="Nicolas_S_feature" /locus_tag="new_3918262_3918330_c" /HighExp="M0t90, M40t90, Lbtran, Lbstat, M40t45, S2, nit, ferm, LBGstat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="0.626, 1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1471" promotor_-10 complement(3388608..3388627) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3388621) /Source="Nicolas_upshifts" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3388623..3388808) /Source="Nicolas_S_feature" /locus_tag="new_3918332_3918517_c" /HighExp="LBGstat, Heat, G150, G135, LBGtran, G180, BMM, Salt, LBGexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1472" promotor_-35 complement(3388640..3388644) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3388739..3388744 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3388760..3388778 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3388765 /Source="Nicolas_upshifts" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3388799..3388818) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3388808) /Source="Nicolas_upshifts" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3388810..3388919) /Source="Nicolas_S_feature" /locus_tag="new_3918519_3918628_c" /HighExp="Heat, Salt, LBGstat, BMM, Oxctl, H2O2, MG 15, UNK1, MG-0.1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1473" promotor_-35 complement(3388833..3388837) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3388875 /Source="Nicolas_upshifts" /id="D1975" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.69533" /MaxDrop="4.01393" /score="13.5410442" /energy="-16.4" /TU="U3001" /idTUdmin="U3001" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3388904..3388923) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3388919) /Source="Nicolas_upshifts" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3388939..3388943) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3388997..3389015) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3389002..3389008 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3389014) /Source="Nicolas_upshifts" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3389023..3389041 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3389026 /Source="Nicolas_upshifts" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3389031..3389036) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3389068..3389313 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391697.2" /db_xref="EnsemblGenomes-Gn:BSU38180" /db_xref="EnsemblGenomes-Tr:CAB15844" /db_xref="GOA:O32282" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG14162" /db_xref="UniProtKB/Swiss-Prot:O32282" /translation="MSFLISLIVAIIIGWLGSLFVKGDMPGGIIGSMIAGLIGAWIGH GLLGTWGPHLAGFAIIPAVIGAAIVVFLVSLLTRKRG*" /label="ywzA CDS" gene 3389068..3389313 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /label="ywzA gene" downshifts 3389295 /Source="Nicolas_upshifts" /id="D1976" /incds=0 /nref=125 /ntot=189 /MaxReadThrough="2.63086" /MaxDrop="7.72876" /score="13.5410442" /energy="-16.4" /TU="NA" /idTUdmin="U3005" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3389384..3390925) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /EC_number="2.7.7.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917, 11790749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917, 11790749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactose-1-phosphate uridyltransferase" /protein_id="NP_391698.2" /db_xref="EnsemblGenomes-Gn:BSU38190" /db_xref="EnsemblGenomes-Tr:CAB15845" /db_xref="GOA:P39575" /db_xref="InterPro:IPR000766" /db_xref="InterPro:IPR005849" /db_xref="InterPro:IPR005850" /db_xref="InterPro:IPR023425" /db_xref="SubtiList:BG10582" /db_xref="UniProtKB/Swiss-Prot:P39575" /translation="MSIIEHLEQLLEYGLERKLISIWDREYTRNRLYEALGITHPEPN SSTSIKQSQSLPDLLAPIYKWAAETGRMEADTDTYRDLLSAKLMGCFVPAPSEVIRKF EETKALYGPKQATKEFYQYSEDVYYIRTDRIAKNVHWTVPTEYGELEMTINLSKPEKD PKAIAAAKEQEQTNYPMCLLCKENVGFEGSVNHPARQNHRIIPVILEDEQWFLQFSPY VYYPEHCIVLKGEHEPMEISKKTFERLLSFLGQYPHYFIGSNADLPIVGGSILSHDHF QGGAHDFPMARAEAEDVYELNDYPGVSLGLVKWPMSVLRLQGDEPGHVAEAADHIFRT WQTYSDEKAGIAAYTGDTPHNTVTPIARRRGDLYELDIVLRNNRTDEEHPLGIFHPHQ EVHHIKKENIGLIEVMGLAILPGRLQEEMKETAAALCSADPKTALEQNPLTAKHSEWA LRTMEKRTITKENVDLVIKEELGHVFARILEHAGVFKQTAEGKQAFRRFIDQLGAKPV KSLNR*" /label="galT CDS" gene complement(3389384..3390925) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /label="galT gene" downshifts complement(3389413) /Source="Nicolas_upshifts" /id="D1977" /incds=0 /nref=190 /ntot=254 /MaxReadThrough="0.3431" /MaxDrop="6.63153" /score="21.0691542" /energy="-14.7" /TU="NA" /idTUdmin="U3006" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3390929..3392101) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /EC_number="2.7.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactokinase" /protein_id="NP_391699.1" /db_xref="EnsemblGenomes-Gn:BSU38200" /db_xref="EnsemblGenomes-Tr:CAB15846" /db_xref="GOA:P39574" /db_xref="InterPro:IPR000705" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR006206" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR019539" /db_xref="InterPro:IPR019741" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022963" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10581" /db_xref="UniProtKB/Swiss-Prot:P39574" /translation="MREELKGIFASVFGEKEGLRFFFAPGRVNLIGEHTDYNGGHVFP CALTMGTYAAVAERNDGLVRMYSDNFRNAGIKECSLDDIRYQKEDDWANYPKGVIYEF QQRGYAVPHGFDIVFSGNIPNGAGLSSSASIELLMGVVLQSYFHPEVDALELVKMAQH AENHFIGVNCGIMDQFAIGMGKKHHAMLLNCDTLDYEYSKLNVSGLALVIANTNKKRT LADSSYNTRRQECNDALLDLKKGLDIAALGDIKPSDFDAHSSLIQNETNRRRAKHAVY ENHRAIKTAHMFKENNIDEIGQLMKESHLSLKDDYEVTCPELDELVFAAWDHEGVIGS RMTGAGFGGCTISIVKDEFVDDFIQKVGDRYQEKTGLRADFYVADIGEGARELKGE*" /label="galK CDS" gene complement(3390929..3392101) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /label="galK gene" promotor_-10 complement(3392119..3392137) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3392141) /Source="Nicolas_upshifts" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3392152..3392158) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3392182..3392565) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882654, 15849754, 16850406, 18192405; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall glycosylation protein" /protein_id="NP_391700.1" /db_xref="EnsemblGenomes-Gn:BSU38210" /db_xref="EnsemblGenomes-Tr:CAB15847" /db_xref="GOA:P39602" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG10580" /db_xref="UniProtKB/Swiss-Prot:P39602" /translation="MYIIMGVFTTIVNIASFYILVEIMNVDYKAATVAAWILSVLFAY ITNKLYVFQQKTHDLQSLLKELTAFFSVRVLSLGIDLGMMIILVGQFNTNETLAKILD NAVIVVVNYVASKWLVFKKTKEEGV*" /label="ywcD CDS" gene complement(3392182..3392565) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /label="ywcD gene" CDS complement(3392583..3393254) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of slrA (biofilm formation)" /protein_id="NP_391701.2" /db_xref="EnsemblGenomes-Gn:BSU38220" /db_xref="EnsemblGenomes-Tr:CAB15848" /db_xref="GOA:P39601" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10579" /db_xref="UniProtKB/Swiss-Prot:P39601" /translation="MKKNKFQIKREATFESFIDAGVNLLIDRAYDPVSVEDISRAAGY SKGAFYVHFVSKDDFLLYLLEKRQMKKKIIIGYLDQMERESVKSLTLDEAAKHAAELL YSYYINKPSWDITSFAMNMPTYKVLKKCKAYVRLYELWVEENVLYIKWLKERKLIDAC IDPEYTAKIICAVLDGIIKQSYVLGQPATFRSFLDALSVFFTLDREHERPRILKSFSE SEEHQ*" /label="slrC CDS" gene complement(3392583..3393254) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /label="slrC gene" promotor_-10 complement(3393276..3393295) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3393285) /Source="Nicolas_upshifts" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3393311..3393314) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3393395..3393398 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3393413..3393432 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3393422..3393609 /Source="Nicolas_S_feature" /locus_tag="new_3923131_3923318" /HighExp="T0.30H, T1.0H, Cold, T1.30H, HiOs, T-0.40H, T2.0H, T2.30H, T4.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1474" upshifts 3393422 /Source="Nicolas_upshifts" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="upshifts" CDS 3393610..3393768 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168, 26857544" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168, 26857544; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-repressor of SlrR" /protein_id="YP_003097794.1" /db_xref="EnsemblGenomes-Gn:BSU38229" /db_xref="EnsemblGenomes-Tr:CAX52707" /db_xref="GOA:P0C8M5" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="UniProtKB/Swiss-Prot:P0C8M5" /translation="MKTHVKKDLDKGWHMLIQEARSIGLGIHDVRQFLESETASRKKN HKKTVRQD*" /label="slrA CDS" gene 3393610..3393768 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /label="slrA gene" S_feature 3393769..3394153 /Source="Nicolas_S_feature" /locus_tag="new_3923478_3923862" /HighExp="T0.30H, Cold, T1.30H, T2.0H, T1.0H, HiOs, T2.30H, T3.0H, LBGstat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1475" promotor_-35 3394134..3394139 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3394155..3394173 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3394155 /Source="Nicolas_upshifts" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="upshifts" CDS 3394211..3394519 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of acetate transporter as a volatile signal for biofilm formation" /protein_id="NP_391702.1" /db_xref="EnsemblGenomes-Gn:BSU38230" /db_xref="EnsemblGenomes-Tr:CAB15849" /db_xref="GOA:P39600" /db_xref="InterPro:IPR007436" /db_xref="SubtiList:BG10578" /db_xref="UniProtKB/Swiss-Prot:P39600" /translation="MYKADYKQIAATPSFQAFLKQKRAFIVPSAIFFFVFYFSLPVLT SYFTFLNAPAIGAVSWAWLFAIAQFAMTWILSTVYSRRAAHFDKYVSALKEDLKGEQT *" /label="vbfB CDS" gene 3394211..3394519 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /label="vbfB gene" downshifts complement(3394297) /Source="Nicolas_upshifts" /id="D1978" /incds=1 /nref=3 /ntot=15 /MaxReadThrough="0.42282" /MaxDrop="5.4957" /score="10.1452497" /energy="-8.3" /TU="NA" /idTUdmin="U3010" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3394301..3394401) /Source="Nicolas_upshift_promotors" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3394341) /Source="Nicolas_upshifts" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3394516..3396057 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="acetate Na+-dependent symporter subunit involvedin volatile signal for biofilm formation" /protein_id="NP_391703.2" /db_xref="EnsemblGenomes-Gn:BSU38240" /db_xref="EnsemblGenomes-Tr:CAB15850" /db_xref="GOA:P39599" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG10577" /db_xref="UniProtKB/Swiss-Prot:P39599" /translation="MNMTAFLLFLAIVGLTLIITYFAAKRTKTTSEFYTAGGGLTGVQ NGLAIAGDYMSAASFLGIAGMIALYGFDGFFYSIGFLVAYLVVLYIVAEPLRNLGKYT MADMIAARFKEKKIRGVAALNTIAISTFYMIAQLVGAGALIKLLLGLDYTAAVLIVGV LMTIYVVFGGMIATSWVQIIKAVLLMAGTLVISIIVFSKFGFSLNTMFEQMKTATPLG ADFLNPGNKYKVPLETLSLNLALVLGTAGLPHILIRFYTVKDAKTARTSVVSATWIIG VFYIMTVFLGFGAAAFVGFDAITAADQAGNMAAPLLAKALGGDFLFAFVSAIAFATIL AVVTGLVLSAASAFAHDIYSQIIRKGEATEKEQMKAARWASVAVSVLSILLAIFAQSL NVAFLVALAFAVAASANLPLIVFTVFWKRFNASGALWGSLTGLISALVLVSMSPSVWD PAGGAIFTGDPLIPLSNPGIISIPLGFLGAWLGTVLSSDKTIDEDTFAEIQVKAHTGV HMEQE*" /label="vbfA CDS" gene 3394516..3396057 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /label="vbfA gene" downshifts 3396048 /Source="Nicolas_upshifts" /id="D1979" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="2.40129" /MaxDrop="4.15104" /score="2.66606932" /energy="-7.8" /TU="NA" /idTUdmin="U3009" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3396088..3396690) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reductase" /protein_id="NP_391704.1" /db_xref="EnsemblGenomes-Gn:BSU38250" /db_xref="EnsemblGenomes-Tr:CAB15851" /db_xref="GOA:P39598" /db_xref="InterPro:IPR001853" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10576" /db_xref="UniProtKB/Swiss-Prot:P39598" /translation="MTVHIKVYSDYVCPFCFVGKAAFEEAIKGKDVEVEWMPFELRPS PSPQLDPVNDPSKQYMWQTSIQPMAEKLGVEINFPNVSPHPYTDLAFEGFHFAKEYNK GHEYNTRVFQAFFQEDQNIGDIDILTKLAEEVGLDGASFKSALETRTYQDVQRQALKH AYEEADITAVPTFIIGDTVIPGAAGKDVFEKAISDEQKKK*" /label="ywbO CDS" gene complement(3396088..3396690) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /label="ywbO gene" downshifts complement(3396102) /Source="Nicolas_upshifts" /id="D1980" /incds=0 /nref=12 /ntot=123 /MaxReadThrough="1.89374" /MaxDrop="3.51247" /score="21.9354981" /energy="-7.8" /TU="NA" /idTUdmin="U3011" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3396691..3396972) /Source="Nicolas_S_feature" /locus_tag="new_3926400_3926681_c" /HighExp="T1.0H, G135, G150, T1.30H, Lbexp, G180, Lbstat, dia5, LBGexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.984, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1476" CDS complement(3396973..3398223) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /EC_number="1.11.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxidase converting ferric iron into ferrous iron" /protein_id="NP_391705.1" /db_xref="EnsemblGenomes-Gn:BSU38260" /db_xref="EnsemblGenomes-Tr:CAB15852" /db_xref="GOA:P39597" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR006313" /db_xref="InterPro:IPR006314" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019546" /db_xref="SubtiList:BG10575" /db_xref="UniProtKB/Swiss-Prot:P39597" /translation="MSDEQKKPEQIHRRDILKWGAMAGAAVAIGASGLGGLAPLVQTA AKPSKKDEKEEEQIVPFYGKHQAGITTAHQTYVYFAALDVTAKDKSDIITLFRNWTSL TQMLTSGKKMSAEQRNQYLPPQDTGESADLSPSNLTVTFGFGPGFFEKDGKDRFGLKS KKPKHLAALPAMPNDNLDEKQGGGDICIQVCADDEQVAFHALRNLLNQAVGTCEVRFV NKGFLSGGKNGETPRNLFGFKDGTGNQSTKDDTLMNSIVWIQSGEPDWMTGGTYMAFR KIKMFLEVWDRSSLKDQEDTFGRRKSSGAPFGQKKETDPVKLNQIPSNSHVSLAKSTG KQILRRAFSYTEGLDPKTGYMDAGLLFISFQKNPDNQFIPMLKALSAKDALNEYTQTI GSALYACPGGCKKGEYIAQRLLES*" /label="efeB CDS" gene complement(3396973..3398223) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /label="efeB gene" downshifts complement(3397069) /Source="Nicolas_upshifts" /id="D1981" /incds=1 /nref=67 /ntot=232 /MaxReadThrough="5.0552" /MaxDrop="3.65898" /score="21.9354981" /energy="-7.8" /TU="U3011,U3012" /idTUdmin="U3011" /TUdmin="-967" /isTUend="FALSE" /label="downshifts" CDS complement(3398242..3399399) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipoprotein binding ferrous or ferric iron for transport" /protein_id="NP_391706.1" /db_xref="EnsemblGenomes-Gn:BSU38270" /db_xref="EnsemblGenomes-Tr:CAB15853" /db_xref="GOA:P39596" /db_xref="InterPro:IPR018976" /db_xref="InterPro:IPR034981" /db_xref="SubtiList:BG10574" /db_xref="UniProtKB/Swiss-Prot:P39596" /translation="MNFTKIAVSAGCILALCAGCGANDTSSTKEKASSEKSGVTKEIT ASVNKMETIISKLNDSVEKGDQKEIEKKGKELNSYWLSFENDIRSDYPFEYTEIEKHL QPIYTEAQKDKPDAGKIKTESESLKASLEDLTEAKKSGKKASDQLAKAADEYKGYVKE QSDQLVKATEAFTGAVKSGDIEKSKTLYAKARVYYERIEPIAESLGDLDPKIDAREND VEEGDKWTGFHKLEKAIWKDQDISGEKATADQLLKDVKELDGSIQSLKLTPEQIVAGA MELLNEAGISKITGEEERYSRIDLVDLMANVEGSEAVYQTVKSALVKDHSDLTEKLDT EFSEFEVLMAKYKTNDQSYTSYDKLSEKQIRELSTKLTTLSETMSKIANVL*" /label="efeM CDS" gene complement(3398242..3399399) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /label="efeM gene" misc_feature complement(3398315..3398334) /Source="Nicolas_upshift_promotors" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3398342) /Source="Nicolas_upshifts" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3399396..3400841) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrous ion permease" /protein_id="NP_391707.2" /db_xref="EnsemblGenomes-Gn:BSU38280" /db_xref="EnsemblGenomes-Tr:CAB15854" /db_xref="GOA:P39595" /db_xref="InterPro:IPR004923" /db_xref="SubtiList:BG10573" /db_xref="UniProtKB/Swiss-Prot:P39595" /translation="MARGLALILFSLLMVFGSAAHAEDDPIAALIQLNKQMIKSVKDG DMDSAQQTFDTFKAKWKKEEPSIKKENLSSHSEMDANIAMISLSFINQDARKLKTQLE ELASHLETYQQAVVLKKTSSGQSRASLTAYIQSLKDTKQFIEKKQLDEASSAIDNLVT SWLAVEGDVVSQSKEAYTTSEENLALMKAEIGSHPEKVSKQIDEMIQLLEPIASSSYS WWDAALIPVREGMEALLVIGALLTMTKKARVTRSSTWIWGGASAGMAVSLAAGIGVTV LFSSSVFGENNFLLGGVTGVLSAVMLLYVGVWLHRNASMDKWREKINIQKSQALKKRS LLSFALIAFLAVVREGLETVIFFIGLVGKLPLTELIGGTAAGLIVLVIVGVLMIKLGM RIPLKPFFLLSMAVVLYMCVKFLGTGVHSLQLAGILPSDAESWLPSVSVLGIYPSVYS TIPQMLILLFLLIALVSEAAKHFTNGKELTK*" /label="efeU CDS" gene complement(3399396..3400841) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /label="efeU gene" promotor_-10 complement(3400875..3400894) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3400885) /Source="Nicolas_upshifts" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3400908..3400915) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3400998..3401666) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /EC_number="2.5.1.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10382260, 16291685, 19888457, 22616866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-phosphate pyrophosphorylase (thiamine phosphate synthase)" /protein_id="NP_391708.1" /db_xref="EnsemblGenomes-Gn:BSU38290" /db_xref="EnsemblGenomes-Tr:CAB15855" /db_xref="GOA:P39594" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR034291" /db_xref="InterPro:IPR036206" /db_xref="PDB:1G4E" /db_xref="PDB:1G4P" /db_xref="PDB:1G4S" /db_xref="PDB:1G4T" /db_xref="PDB:1G67" /db_xref="PDB:1G69" /db_xref="PDB:1G6C" /db_xref="PDB:2TPS" /db_xref="PDB:3O15" /db_xref="PDB:3O16" /db_xref="SubtiList:BG10572" /db_xref="UniProtKB/Swiss-Prot:P39594" /translation="MTRISREMMKELLSVYFIMGSNNTKADPVTVVQKALKGGATLYQ FREKGGDALTGEARIKFAEKAQAACREAGVPFIVNDDVELALNLKADGIHIGQEDANA KEVRAAIGDMILGVSAHTMSEVKQAEEDGADYVGLGPIYPTETKKDTRAVQGVSLIEA VRRQGISIPIVGIGGITIDNAAPVIQAGADGVSMISAISQAEDPESAARKFREEIQTY KTGR*" /label="thiE CDS" gene complement(3400998..3401666) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /label="thiE gene" downshifts complement(3401007) /Source="Nicolas_upshifts" /id="D1982" /incds=0 /nref=44 /ntot=194 /MaxReadThrough="1.62789" /MaxDrop="4.13196" /score="10.8502035" /energy="-10" /TU="NA" /idTUdmin="U3013" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3401663..3402481) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /EC_number="2.7.1.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10382260, 16291685, 22938038, 28729425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10382260, 16291685, 22938038, 28729425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-(2-hydroxyethyl)-4-methylthiazole kinase" /protein_id="NP_391709.1" /db_xref="EnsemblGenomes-Gn:BSU38300" /db_xref="EnsemblGenomes-Tr:CAB15856" /db_xref="GOA:P39593" /db_xref="InterPro:IPR000417" /db_xref="InterPro:IPR029056" /db_xref="PDB:1C3Q" /db_xref="PDB:1EKK" /db_xref="PDB:1EKQ" /db_xref="PDB:1ESJ" /db_xref="PDB:1ESQ" /db_xref="SubtiList:BG10571" /db_xref="UniProtKB/Swiss-Prot:P39593" /translation="MDAQSAAKCLTAVRRHSPLVHSITNNVVTNFTANGLLALGASPV MAYAKEEVADMAKIAGALVLNIGTLSKESVEAMIIAGKSANEHGVPVILDPVGAGATP FRTESARDIIREVRLAAIRGNAAEIAHTVGVTDWLIKGVDAGEGGGDIIRLAQQAAQK LNTVIAITGEVDVIADTSHVYTLHNGHKLLTKVTGAGCLLTSVVGAFCAVEENPLFAA IAAISSYGVAAQLAAQQTADKGPGSFQIELLNKLSTVTEQDVQEWATIERVTVS*" /label="thiM CDS" gene complement(3401663..3402481) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /label="thiM gene" CDS complement(3402489..3403394) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23504016; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family, cidAB expression)" /protein_id="NP_391710.1" /db_xref="EnsemblGenomes-Gn:BSU38310" /db_xref="EnsemblGenomes-Tr:CAB15857" /db_xref="GOA:P39592" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10570" /db_xref="UniProtKB/Swiss-Prot:P39592" /translation="MDIRHLTYFLEVARLKSFTKASQSLYVSQPTISKMIKNLEEELG IELFYRNGRQVELTDAGHSMYVQAQEIIKSFQNLTSELNDIMEVKKGHVRIGLPPMIG SGFFPRVLGDFRENYPNVTFQLVEDGSIKVQEGVGDGSLDIGVVVLPANEDIFHSFTI VKETLMLVVHPSHRLADEKECQLRELKDEPFIFFREDFVLHNRIMTECIKAGFRPHII YETSQWDFISEMVSANLGIGLLPERICRGLDPEKVKVIPLVDPVIPWHLAIIWRKDRY LSFAARAWLEHTKSYLWDPKKDSKG*" /label="cidR CDS" gene complement(3402489..3403394) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /label="cidR gene" misc_feature complement(3403129..3403148) /Source="Nicolas_upshift_promotors" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3403140) /Source="Nicolas_upshifts" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3403435..3403454) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3403445..3403452 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3403456) /Source="Nicolas_upshifts" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="upshifts" upshifts 3403464 /Source="Nicolas_upshifts" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3403466..3403485 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3403470..3403477) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3403500..3403886 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 22383849, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator of murein hydrolases" /protein_id="NP_391711.1" /db_xref="EnsemblGenomes-Gn:BSU38320" /db_xref="EnsemblGenomes-Tr:CAB15858" /db_xref="GOA:P39591" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023760" /db_xref="SubtiList:BG10569" /db_xref="UniProtKB/Swiss-Prot:P39591" /translation="MKKLLLTVIQIALLFIFARLINWVTALLHINIPGSIIGIVILFT LLHFNIIKLEWIELGAAWLLGELLLFFIPSAVGVIEYGDIMSKFGVSILLVVIISTFV VMVSTGTLTQLIAKRKEKKHTCSSEL*" /label="cidA CDS" gene 3403500..3403886 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /label="cidA gene" CDS 3403868..3404545 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator controlling activity of murein hydrolases" /protein_id="NP_391712.2" /db_xref="EnsemblGenomes-Gn:BSU38330" /db_xref="EnsemblGenomes-Tr:CAB15859" /db_xref="GOA:P39590" /db_xref="InterPro:IPR005261" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG10568" /db_xref="UniProtKB/Swiss-Prot:P39590" /translation="MFIGIVSLFLTVLVYLGAKKVYQRFPRVYTSPLLVTPAVLVGLL LLVNVPYESYNLGGGLLTDMLQPATVAFAIPLYKYFPVLKKYAVEIILNVAVGSCIAI ISTALIAKWLHLGTGLIDSLVPRSVTTPIAMNVSEMIGGMPAVTAVFVILTALLGTVI GPMVIRYFRIDNEIARGVLLGTSAHGAGTSKAFELSSVSGTISSVSMILAAIMTLCAA PFLLSFM*" /label="cidB CDS" gene 3403868..3404545 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /label="cidB gene" downshifts 3404517 /Source="Nicolas_upshifts" /id="D1983" /incds=0 /nref=13 /ntot=88 /MaxReadThrough="2.20109" /MaxDrop="4.23919" /score="27.0474383" /energy="-8" /TU="NA" /idTUdmin="U3015" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3404589..3404596 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3404607 /Source="Nicolas_upshifts" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3404610..3404629 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3404649..3405848 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar permease" /protein_id="NP_391713.1" /db_xref="EnsemblGenomes-Gn:BSU38340" /db_xref="EnsemblGenomes-Tr:CAB15860" /db_xref="GOA:P39589" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024989" /db_xref="InterPro:IPR026032" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10567" /db_xref="UniProtKB/Swiss-Prot:P39589" /translation="MHNLQVRRHYAALKGFYLFAFLGTGSIIPLLSMYLTKEQHLSGS QVGLIMSLGPIVMIFFQPFWGMLSDYTQKTKGLLAVCTSITGIIGLAYIAFDSFPLFI LIAACFAAFQSTIIPLSDSISLRYTQETNGNYGGIRLFGSLGFGVAVFAMGQVTNQLY PIHVIFIFGCAFLCIAAILASQVPGQQKTTKVNIRKGFRELISNKTFLIFMIITFTTF APNLANNTYFSLFLDKSGASLSAIGILFFIGVISEIPFMRFAQTFIDKMGLLNVIMLS GGVSLFRWALYFTAPSLWIIYATVFLQGVAIGLFIPAALQYVKKITPRHVEATALTMY AAIGNGFGNWFCTFAGGYIFDYVSIFAVYLLFGILSIAGFGLTLYLMKAEKNKHTLHQ PAVTFKP*" /label="ywbF CDS" gene 3404649..3405848 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /label="ywbF gene" CDS 3405882..3406079 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391714.1" /db_xref="EnsemblGenomes-Gn:BSU38350" /db_xref="EnsemblGenomes-Tr:CAB15861" /db_xref="InterPro:IPR019240" /db_xref="SubtiList:BG10566" /db_xref="UniProtKB/Swiss-Prot:P39588" /translation="MNGQERNSISKGLQVDIVLKADQKTGKLTRGTVKDILTKSNFHP HGIKVRLEDGRIGRDQQIVST*" /label="ywbE CDS" gene 3405882..3406079 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /label="ywbE gene" downshifts 3406058 /Source="Nicolas_upshifts" /id="D1984" /incds=0 /nref=15 /ntot=205 /MaxReadThrough="1.90583" /MaxDrop="4.20528" /score="21.8132292" /energy="-12.2" /TU="NA" /idTUdmin="U3016" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(3406114..3407304) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18786544, 18789337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="large subunit ribosomal RNA m5C1962 methyltransferase" /protein_id="NP_391715.1" /db_xref="EnsemblGenomes-Gn:BSU38360" /db_xref="EnsemblGenomes-Tr:CAB15862" /db_xref="GOA:P39587" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019614" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10565" /db_xref="UniProtKB/Swiss-Prot:P39587" /translation="MKLLTLKKAHAAKIKKGYPLIEKEALAGSAGHMKEGDLVDIVSE SGGEFLARGYYGLQNKGVGWTLTRNKHEQIDQAFFLSKLTKAAQARAKLFEAQDTTAF RLFNGEGDGVGGVTIDYYDGYLLIQWYSKGIYTFKDMLISALDEMDLDYKAIYEKKRF DTAGQYVEDDDFVKGRRGEFPIIIQENGIQYAVDLNEGAMTGIFLDQRHVRKAIRDRY AKGKTVLNTFSYTGAFSVAAALGGAEKTTSVDVANRSLAKTIEQFSVNKLDYEAHDIK VMDVFNYFSYAAKKDLRFDLIILDPPSFARTKKRTFSAAKDYKNLLKETIAITADKGV IVASTNSSAFGMKKFKGFIDAAFKETNERYTIIEEFTLPEDFKTISAFPEGNYLKVVL LQKK*" /label="rlmI CDS" gene complement(3406114..3407304) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /label="rlmI gene" downshifts complement(3406129) /Source="Nicolas_upshifts" /id="D1985" /incds=0 /nref=5 /ntot=127 /MaxReadThrough="0.0525399999999996" /MaxDrop="4.51664" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin=71 /isTUend="FALSE" /label="downshifts" downshifts complement(3406213) /Source="Nicolas_upshifts" /id="D1986" /incds=1 /nref=42 /ntot=233 /MaxReadThrough="2.99734" /MaxDrop="3.89369" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" misc_feature complement(3407328..3407347) /Source="Nicolas_upshift_promotors" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3407344) /Source="Nicolas_upshifts" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3407364..3407371 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3407380 /Source="Nicolas_upshifts" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3407385..3407404 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3407425..3407805 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24330391, 25283443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391, 25283443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase I; hemithioacetal-bacillithiol lactoyl-bacillithiol formation" /protein_id="NP_391716.1" /db_xref="EnsemblGenomes-Gn:BSU38370" /db_xref="EnsemblGenomes-Tr:CAB15863" /db_xref="GOA:P39586" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10564" /db_xref="UniProtKB/Swiss-Prot:P39586" /translation="MAKRIDHTGIMVRDINASITFYEEVLGMKLKDRITHTNGVIELA FLGFEDGPETEIELIQGYSSELPAEGKVHHIALLTDDIAAEYTKAEKMNAKFIDEEIT TLPNGYRYFYIEGPDGEWIEFFQR*" /label="glxA CDS" gene 3407425..3407805 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /label="glxA gene" downshifts 3407703 /Source="Nicolas_upshifts" /id="D1987" /incds=1 /nref=14 /ntot=215 /MaxReadThrough="3.76076" /MaxDrop="3.68951" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-357" /isTUend="FALSE" /label="downshifts" downshifts 3407774 /Source="Nicolas_upshifts" /id="D1988" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="3.05249" /MaxDrop="3.56101" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" CDS complement(3407843..3408520) /gene="ywbB" /locus_tag="BSU_38380" /old_locus_tag="BSU38380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391717.1" /db_xref="EnsemblGenomes-Gn:BSU38380" /db_xref="EnsemblGenomes-Tr:CAB15864" /db_xref="InterPro:IPR024250" /db_xref="SubtiList:BG10563" /db_xref="UniProtKB/Swiss-Prot:P39585" /translation="MLDYIWLDDESPILQQVPVEYSSAALIFSPFIQMPEGWENAKRK NDYEHIYPNDNEIRGIGKAVSWKKVMSSCGFQTHAELALALMTSIGALRDEFAREDLA EVLHENINGDLYYPSEDHISNFHIPSLVKVLGANGSNRFYYAEPIVENRGVLDITEAN LRTVLDEAATELVLTDEKMDFVFMSVYDSFINVFLAKDKNIHELVERMGWEAMICDES TYISWYR*" /label="ywbB CDS" gene complement(3407843..3408520) /gene="ywbB" /locus_tag="BSU_38380" /old_locus_tag="BSU38380" /label="ywbB gene" downshifts complement(3407850) /Source="Nicolas_upshifts" /id="D1989" /incds=0 /nref=6 /ntot=156 /MaxReadThrough="0.15283" /MaxDrop="5.41362" /score="0.491291944" /energy="-11.7" /TU="NA" /idTUdmin="U3020" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3408529..3408548) /Source="Nicolas_upshift_promotors" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3408554) /Source="Nicolas_upshifts" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3408560..3408566) /Source="Nicolas_upshift_promotors" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3408597..3409931) /gene="ywbA" /locus_tag="BSU_38390" /old_locus_tag="BSU38390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8990303, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cellobiose phosphotransferase system enzyme IIC permease component" /protein_id="NP_391718.1" /db_xref="EnsemblGenomes-Gn:BSU38390" /db_xref="EnsemblGenomes-Tr:CAB15865" /db_xref="GOA:P39584" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG10562" /db_xref="UniProtKB/Swiss-Prot:P39584" /translation="MSTFTRVMEEKIMPVAGKIAGQRHLSALRDGIILTMPLIIIGSV FLILTSLPIPGYADFMASVFGNEWADKLGYPVNASFDIMAMIAAFGIAYRLAESYGVD ALSAGAISIAAFLLATPFEVPFTPHGSTESIMVGGGIPITLLGSKGLFVAMLIALFST EIYRYIIQKNIVFKMPDGVPPAVSKSFVALIPGFIIVLLVWLARLLIEMTPFQSLHNV VGDLLGTPLSILGGSLGGSLIAEFVQMLLWSCGIHGASIIGGIMAPIWYGAMDANRLA FQAGEALPSIFTTQFFQIWINVGGSGATLALVLTMLVRSRSKQMKQLGRLGIGPALFN INEPIIFGMPIVMNPLLIVPFIIAPLLTITATYIGMSTGLVARPAGIAVPWTMPPLIS GYLATGGKVSGAVMQLVNLLITCAIYYPFFRIWDHQKWREESAVESGDKNVM*" /label="ywbA CDS" gene complement(3408597..3409931) /gene="ywbA" /locus_tag="BSU_38390" /old_locus_tag="BSU38390" /label="ywbA gene" misc_feature complement(3409979..3409997) /Source="Nicolas_upshift_promotors" /id="U3020" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.596403596403596" /psig="0.596403596403596" /xcortree=1254 /SigmaFactorBS="tttagcaaaatgcagattttttccgcatgaagaggaaatttt ccaaatgaatttgtaagcgttttCAAAATAAGATAAAGAAAAcattgcggaggttgtt c" /listShort="ywbA, ywbB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3410002) /Source="Nicolas_upshifts" /id="U3020" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.596403596403596" /psig="0.596403596403596" /xcortree=1254 /SigmaFactorBS="tttagcaaaatgcagattttttccgcatgaagaggaaatttt ccaaatgaatttgtaagcgttttCAAAATAAGATAAAGAAAAcattgcggaggttgtt c" /listShort="ywbA, ywbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3410096..3410103 /Source="Nicolas_upshift_promotors" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3410108 /Source="Nicolas_upshifts" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3410117..3410135 /Source="Nicolas_upshift_promotors" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3410159..3412096 /gene="epr" /locus_tag="BSU_38400" /old_locus_tag="BSU38400" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1938892, 2116590, 16553828, 17666034, 19416356, 23660663, 25966269" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938892, 2116590, 16553828, 17666034, 19416356, 23660663, 25966269; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular serine protease" /protein_id="NP_391719.1" /db_xref="EnsemblGenomes-Gn:BSU38400" /db_xref="EnsemblGenomes-Tr:CAB15866" /db_xref="GOA:P16396" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10561" /db_xref="UniProtKB/Swiss-Prot:P16396" /translation="MKNMSCKLVVSVTLFFSFLTIGPLAHAQNSSEKEVIVVYKNKAG KETILDSDADVEQQYKHLPAVAVTADQETVKELKQDPDILYVENNVSFTAADSTDFKV LSDGTDTSDNFEQWNLEPIQVKQAWKAGLTGKNIKIAVIDSGISPHDDLSIAGGYSAV SYTSSYKDDNGHGTHVAGIIGAKHNGYGIDGIAPEAQIYAVKALDQNGSGDLQSLLQG IDWSIANRMDIVNMSLGTTSDSKILHDAVNKAYEQGVLLVAASGNDGNGKPVNYPAAY SSVVAVSATNEKNQLASFSTTGDEVEFSAPGTNITSTYLNQYYATGSGTSQATPHAAA MFALLKQRDPAETNVQLREEMRKNIVDLGTAGRDQQFGYGLIQYKAQATDSAYAAAEQ AVKKAEQTKAQIDINKARELISQLPNSDAKTALHKRLDKVQSYRNVKDAKDKVAKAEK YKTQQTVDTAQTAINKLPNGTDKKNLQKRLDQVKRYIASKQAKDKVAKAEKSKKKTDV DSAQSAIGKLPASSEKTSLQKRLNKVKSTNLKTAQQSVSAAEKKSTDANAAKAQSAVN QLQAGKDKTALQKRLDKVKKKVAAAEAKKVETAKAKVKKAEKDKTKKSKTSAQSAVNQ LKASNEKTKLQKRLNAVKPKK*" /label="epr CDS" gene 3410159..3412096 /gene="epr" /locus_tag="BSU_38400" /old_locus_tag="BSU38400" /label="epr gene" promotor_-10 complement(3411303..3411322) /Source="Nicolas_upshift_promotors" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3411304) /Source="Nicolas_upshifts" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3411336..3411344) /Source="Nicolas_upshift_promotors" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3412086 /Source="Nicolas_upshifts" /id="D1990" /incds=0 /nref=175 /ntot=224 /MaxReadThrough="1.26567" /MaxDrop="6.00181" /score="15.6173594" /energy="-13" /TU="NA" /idTUdmin="U3021" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3412199..3412206 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3412221..3412240 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3412240 /Source="Nicolas_upshifts" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3412452..3412459 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3412472..3412491 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3412472 /Source="Nicolas_upshifts" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="upshifts" CDS 3412524..3413903 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11580842, 1400159, 8535520, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11580842, 1400159, 8535520, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of SacY" /protein_id="NP_391720.1" /db_xref="EnsemblGenomes-Gn:BSU38410" /db_xref="EnsemblGenomes-Tr:CAB15867" /db_xref="GOA:P15400" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10560" /db_xref="UniProtKB/Swiss-Prot:P15400" /translation="MHKEIAKELLLLAGGKNNIISISHCTTRLRFDVKDETKIDIHAI ENLQGVQGTFFRYGLFQIIFGAGVVNKIYKEVVHVWETAPSEEPVHQKKASRKLNPAA AFAKTLSDIFVPIIPAITASGLLMGLIGMIKVFHWFAAGSPWIKMLDLVSSTAFILLP ILVGFSAARQFGSNPYLGAVIAGLLTHPDLLDPSMLGSKTPSSLDIWGLHIPMMGYQG SMIPILLSVFVMSKIEKLLKSIVPKSLDVVIIPFITVMVTGCLALIVMNPAASIIGQI MTQSIVYIYDHAGIAAGALFGGIYSTIVLSGLHHSFYAIEATLLANPHVGVNFLVPIW SMANVAQGGAGLAVFLKTKQSSLKKIALPASLTAFLGIVEPIVFGVNLKLIRPFIGAA IGGAIGGAYVVAVQVVANSYGLTGIPMISIVLPFGAANFVHYMIGFLIAAVSAFIATL FLGFKEETE*" /label="sacX CDS" gene 3412524..3413903 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /label="sacX gene" S_feature complement(3413612..3414815) /Source="Nicolas_S_feature" /locus_tag="new_3943322_3944525_c" /HighExp="Etha, B36, B60, M9-stat, Salt, Sw, LoTm, C30, Gly, Heat" /AntisenseName="sacY" /AntisenseCor="-0.177403958488455" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1477" CDS 3413957..3414799 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9305644, 9457872, 11580842, 12079345, 15528654, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9305644, 9457872, 11580842, 12079345, 15528654, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391721.1" /db_xref="EnsemblGenomes-Gn:BSU38420" /db_xref="EnsemblGenomes-Tr:CAB15868" /db_xref="GOA:P15401" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1AUU" /db_xref="SubtiList:BG10559" /db_xref="UniProtKB/Swiss-Prot:P15401" /translation="MKIKRILNHNAIVVKDQNEEKILLGAGIAFNKKKNDIVDPSKIE KTFIRKDTPDYKQFEEILETLPEDHIQISEQIISHAEKELNIKINERIHVAFSDHLSF AIERLSNGMVIKNPLLNEIKVLYPKEFQIGLWARALIKDKLGIHIPDDEIGNIAMHIH TARNNAGDMTQTLDITTMIRDIIEIIEIQLSINIVEDTISYERLVTHLRFAIQHIKAG ESIYELDAEMIDIIKEKFKDAFLCALSIGTFVKKEYGFEFPEKELCYIAMHIQRFYQR SVAR*" /label="sacY CDS" gene 3413957..3414799 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /label="sacY gene" CDS complement(3414850..3415710) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11377871, 19659723; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase (general stress protein)" /protein_id="NP_391722.1" /db_xref="EnsemblGenomes-Gn:BSU38430" /db_xref="EnsemblGenomes-Tr:CAB15869" /db_xref="GOA:P25148" /db_xref="InterPro:IPR002495" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10558" /db_xref="UniProtKB/Swiss-Prot:P25148" /translation="MRKDEIMHIVSCADDNYARHLGGMFVSLLTNMDQEREVKLYVID GGIKPDNKKRLEETTLKFGVPIEFLEVDTNMYEHAVESSHITKAAYYRISIPDLIKDE SIKRMIYIDCDALVLEDISKLWDLDIAPYTVAAVEDAGQHERLKEMNVTDTGKYFNSG IMIIDFESWRKQNITEKVINFINEHPDEDFLVLHDQDALNAILYDQWYELHPRWNAQT YIMLKLKTPSTLLGRKQYNETRENPAIVHFCGGEKPWNSNTKHPYRDEYFHYMSYTKW NTIGNPAINQ*" /label="gspA CDS" gene complement(3414850..3415710) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /label="gspA gene" downshifts complement(3414860) /Source="Nicolas_upshifts" /id="D1991" /incds=0 /nref=73 /ntot=227 /MaxReadThrough="5.61926" /MaxDrop="7.47527" /score="21.8603429" /energy="-10.6" /TU="U3025" /idTUdmin="U3025" /TUdmin="-1224" /isTUend="FALSE" /label="downshifts" downshifts 3415694 /Source="Nicolas_upshifts" /id="D1992" /incds=0 /nref=8 /ntot=30 /MaxReadThrough="1.49599" /MaxDrop="5.33818" /score="10.6843241" /energy="-4.5" /TU="NA" /idTUdmin="U3026" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3415732..3415750) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3415750) /Source="Nicolas_upshifts" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3415765..3415771) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3415820..3416533) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391723.1" /db_xref="EnsemblGenomes-Gn:BSU38440" /db_xref="EnsemblGenomes-Tr:CAB15870" /db_xref="GOA:P25149" /db_xref="InterPro:IPR011737" /db_xref="SubtiList:BG10557" /db_xref="UniProtKB/Swiss-Prot:P25149" /translation="MQKYVQSDYKHDPFHLFSTEHVVTLAIISLLAILLFLFQDEVKQ PRASRFLRSLFVFLLLGSQIGYQIWMVATDRWSVRTSLPLQLSDLSVYLSAIMLVTKS RKLFVFLFFVGIGSSIQALATPDLGMFSFPHIRYILFFISHGSVFLSCLLMAVIGTYR MGQRSLWVTVLLVNVYGVCIFLIDRWLGANYMYLTKKPGGSSLLDVLGPWPWYIVSAE AITIASFFILYWLYRIFKK*" /label="ywaF CDS" gene complement(3415820..3416533) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /label="ywaF gene" promotor_-35 3415935..3415936 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3415956..3415973 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3415958 /Source="Nicolas_upshifts" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3416561..3416572) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3416562) /Source="Nicolas_upshifts" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3416587..3416593) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3416608..3416614 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3416629..3416648 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3416639 /Source="Nicolas_upshifts" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="upshifts" CDS 3416684..3417199 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25733610; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling expressionof tyrZ" /protein_id="NP_391724.1" /db_xref="EnsemblGenomes-Gn:BSU38450" /db_xref="EnsemblGenomes-Tr:CAB15871" /db_xref="GOA:P25150" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10556" /db_xref="UniProtKB/Swiss-Prot:P25150" /translation="MERSHQHQQLRKEEHDTLSKLKQMPVESLNLEAISIATNLYRSA QRLRVKMETEVLSTYNLSWTAFSILYDLWVWGALETRKIAELSGISTATASNVIKTLE KKSFCRKSIDTRDRRLVFVSITDSGKQAIEELYPEFHKGETELIAGMTKDEQKILTGL LRKVADNLHTT*" /label="tyrZR CDS" gene 3416684..3417199 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /label="tyrZR gene" misc_RNA 3417200..3417406 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /product="T-box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" /label="tboYB RNA" gene 3417200..3417406 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /label="tboYB gene" downshifts 3417366 /Source="Nicolas_upshifts" /id="D1993" /incds=0 /nref=15 /ntot=112 /MaxReadThrough="1.84575" /MaxDrop="4.56656" /score="23.8000948" /energy="-14.5" /TU="NA" /idTUdmin="U3028" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3417448..3418689 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /EC_number="6.1.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1735721, 1806041, 25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1735721, 1806041, 25733610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_391725.1" /db_xref="EnsemblGenomes-Gn:BSU38460" /db_xref="EnsemblGenomes-Tr:CAB15872" /db_xref="GOA:P25151" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024108" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10555" /db_xref="UniProtKB/Swiss-Prot:P25151" /translation="MMRTFEQLTASQQKEVERQLQLYMTGAHEVIPPEELKAKLVKSI STGTPLKIKLGLDPSAPDVHLGHTVVLNKLRQFQENGHIVQLLIGDFTGKIGDPTGKS AARKQLTDEEVQHNAKTYFEQFGKVLDPEKVELHYNSKWLKTLNLEDVIELAGKITVA RLMERDDFEERIAMQKPISLHEFFYPLMQGYDSVVLESDIELGGTDQHFNVLMGRHFQ ERYNKEKQVVILMPLLEGLDGVEKMSKSKHNYIGINEHPNDMYGKTMSLPDSLMKKYI HLATDLELEEKKQLVKDLETGAVHPRDAKMLLARTIVRMYHGEKAAEAAEHSFKTVFQ ENSLPEDIPAVNWKGEKTIAMIDLLVKLKLLSSKSEARRMIQNGGVRIDGEKVTDVHA KAEIRENMIIQVGKRKFLKLQ*" /label="tyrZ CDS" gene 3417448..3418689 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /label="tyrZ gene" promotor_-35 3418780..3418788 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3418799..3418817 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3418810 /Source="Nicolas_upshifts" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="upshifts" CDS 3418845..3420212 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15668014, 23426795, 26898926, 28257579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668014, 23426795, 26898926, 28257579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported double-zinc aminopeptidase" /protein_id="NP_391726.1" /db_xref="EnsemblGenomes-Gn:BSU38470" /db_xref="EnsemblGenomes-Tr:CAB15873" /db_xref="GOA:P25152" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR007484" /db_xref="SubtiList:BG10554" /db_xref="UniProtKB/Swiss-Prot:P25152" /translation="MKKLLTVMTMAVLTAGTLLLPAQSVTPAAHAVQISNSERELPFK AKHAYSTISQLSEAIGPRIAGTAAEKKSALLIASSMRKLKLDVKVQRFNIPDRLEGTL SSAGRDILLQAASGSAPTEEQGLTAPLYNAGLGYQKDFTADAKGKIALISRGDLTYYE KAKNAEAAGAKAVIIYNNKESLVPMTPNLSGNKVGIPVVGIKKEDGEALTQQKEATLK LKAFTNQTSQNIIGIKKPKNIKHPDIVYVTAHYDSVPFSPGANDNGSGTSVMLEMARV LKSVPSDKEIRFIAFGAEELGLLGSSHYVDHLSEKELKRSEVNFNLDMVGTSWEKASE LYVNTLDGQSNYVWESSRTAAEKIGFDSLSLTQGGSSDHVPFHEAGIDSANFIWGDPE TEEVEPWYHTPEDSIEHISKERLQQAGDLVTAAVYEAVKKEKKPKTIKKQMKAKASDI FEDIK*" /label="eapD CDS" gene 3418845..3420212 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /label="eapD gene" downshifts 3420189 /Source="Nicolas_upshifts" /id="D1994" /incds=0 /nref=3 /ntot=37 /MaxReadThrough="1.38814" /MaxDrop="6.05871" /score="27.7635079" /energy="-13.3" /TU="NA" /idTUdmin="U3029" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(3420242..3420874) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /EC_number="2.7.6.5" /function="16.7: Manage energy" /function="16.3: Control" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_391727.1" /db_xref="EnsemblGenomes-Gn:BSU38480" /db_xref="EnsemblGenomes-Tr:CAB15874" /db_xref="GOA:P39583" /db_xref="InterPro:IPR007685" /db_xref="SubtiList:BG10553" /db_xref="UniProtKB/Swiss-Prot:P39583" /translation="MDLSVTHMDDLKTVMEDWKNELLVYKFALDALDTKFSIISQEYN LIHGHNPIEHTKSRVKSFESIVNKLMRKGCEITTKEMKEHIHDIAGVRIICSFISDIY NVVNVLKQHEDLRIVKVKDYIQTPKPNGYRSLHLIIEMPVNLTNRVEYVKAEIQIRTI AMDFWASLEHKIYYKLNNDVPKQLTDELKEAAEIAHYLDEKMLGIKKEVD*" /label="relQ CDS" gene complement(3420242..3420874) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /label="relQ gene" downshifts complement(3420260) /Source="Nicolas_upshifts" /id="D1995" /incds=0 /nref=200 /ntot=257 /MaxReadThrough="2.49976" /MaxDrop="5.49802" /score="47.236042" /energy="-13.3" /TU="NA" /idTUdmin="U3030" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3420910..3420925) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3420918) /Source="Nicolas_upshifts" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3420938..3420946) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3421016..3421951) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /EC_number="2.5.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6780514, 9573170, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-dihydroxy-2-naphthoate octaprenyltransferase" /protein_id="NP_391728.1" /db_xref="EnsemblGenomes-Gn:BSU38490" /db_xref="EnsemblGenomes-Tr:CAB15875" /db_xref="GOA:P39582" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR004657" /db_xref="InterPro:IPR026046" /db_xref="SubtiList:BG10552" /db_xref="UniProtKB/Swiss-Prot:P39582" /translation="MNQTNKGEGQTAPQKESMGQILWQLTRPHTLTASFVPVLLGTVL AMFYVKVDLLLFLAMLFSCLWIQIATNLFNEYYDFKRGLDTAESVGIGGAIVRHGMKP KTILQLALASYGIAILLGVYICASSSWWLALIGLVGMAIGYLYTGGPLPIAYTPFGEL FSGICMGSVFVLISFFIQTDKINMQSILISIPIAILVGAINLSNNIRDIEEDKKGGRK TLAILMGHKGAVTLLAASFAVAYIWVVGLVITGAASPWLFVVFLSVPKPVQAVKGFVQ NEMPMNMIVAMKSTAQTNTFFGFLLSIGLLISYFR*" /label="menA CDS" gene complement(3421016..3421951) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /label="menA gene" downshifts complement(3421028) /Source="Nicolas_upshifts" /id="D1996" /incds=0 /nref=10 /ntot=113 /MaxReadThrough="3.08081" /MaxDrop="4.6874" /score="16.8971767" /energy="-8.5" /TU="NA" /idTUdmin="U3032" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3421695..3421704 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3421718..3421737 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3421722 /Source="Nicolas_upshifts" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3421952..3422039) /Source="Nicolas_S_feature" /locus_tag="new_3951662_3951749_c" /HighExp="LBGstat, Paraq, G180, LBGexp, G135, Oxctl, C30, Cold, Diami, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.81271400000000005" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.498" /TUlongSig="NA" /TUlongPSig="NA" /label="S1478" promotor_-10 complement(3422022..3422041) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3422039) /Source="Nicolas_upshifts" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3422057..3422061) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3422084..3422096) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3422084) /Source="Nicolas_upshifts" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3422111..3422117) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3422114..3422248) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514012.1" /translation="MECFELIHNKGKDTWSQKIFLTFKKCNVLKKIFLYLFVQVKAET *" /label="hypothetical protein CDS" gene complement(3422114..3422248) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /label="gene" promotor_-35 3422195..3422202 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-35" promotor_-10 3422216..3422235 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-10" upshifts 3422225 /Source="Nicolas_upshifts" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="upshifts" S_feature 3422228..3422332 /Source="Nicolas_S_feature" /locus_tag="new_3951938_3952042" /HighExp="H2O2, Paraq, Oxctl, G180, G150, C30, G135, LBGstat, dia15, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1479" promotor_-35 3422327..3422336 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3422334 /Source="Nicolas_upshifts" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3422348..3422363 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3422370) /Source="Nicolas_upshifts" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3422372..3422386) /Source="Nicolas_upshift_promotors" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3422398..3422547 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical membrane protein" /protein_id="YP_003097795.1" /db_xref="EnsemblGenomes-Gn:BSU38499" /db_xref="EnsemblGenomes-Tr:CAX52708" /db_xref="GOA:C0H3T3" /db_xref="InterPro:IPR021008" /db_xref="UniProtKB/Swiss-Prot:C0H3T3" /translation="MLQLMKQLYEKPAVKWTCHTGFYLMILLVLFFMYGFHTANTGSY IYNDF*" /label="ywzH CDS" gene 3422398..3422547 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /label="ywzH gene" CDS 3422565..3424076 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /EC_number="6.1.1.13" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine:D-alanyl-carrier protein ligase subunit" /protein_id="NP_391729.1" /db_xref="EnsemblGenomes-Gn:BSU38500" /db_xref="EnsemblGenomes-Tr:CAB15876" /db_xref="GOA:P39581" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR010072" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:3E7W" /db_xref="PDB:3E7X" /db_xref="SubtiList:BG10551" /db_xref="UniProtKB/Swiss-Prot:P39581" /translation="MKLLHAIQTHAETYPQTDAFRSQGQSLTYQELWEQSDRAAAAIQ KRISGEKKSPILVYGHMEPHMIVSFLGSVKAGHPYIPVDLSIPSERIAKIIESSGAEL LIHAAGLSIDAVGQQIQTVSAEELLENEGGSVSQDQWVKEHETFYIIYTSGSTGNPKG VQISAANLQSFTDWICADFPVSGGKIFLNQAPFSFDLSVMDLYPCLQSGGTLHCVTKD AVNKPKVLFEELKKSGLNVWTSTPSFVQMCLMDPGFSQDLLPHADTFMFCGEVLPVSV AKALLERFPKAKIFNTYGPTEATVAVTSVEITNDVISRSESLPVGFAKPDMNIFIMDE EGQPLPEGEKGEIVIAGPSVSRGYLGEPELTEKAFFSHEGQWAYRTGDAGFIQDGQIF CQGRLDFQIKLHGYRMELEEIEFHVRQSQYVRSAVVIPYQPNGTVEYLIAAIVPEEHE FEKEFQLTSAIKKELAASLPAYMIPRKFIYQDHIQMTANGKIDRKRIGEEVLV*" /label="dltA CDS" gene 3422565..3424076 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /label="dltA gene" CDS 3424073..3425260 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 15849754, 16850406, 17263852; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine transferase from DCP to undecaprenylphosphate for lipoteichoic acid and wall teichoic acid" /protein_id="NP_391730.1" /db_xref="EnsemblGenomes-Gn:BSU38510" /db_xref="EnsemblGenomes-Tr:CAB15877" /db_xref="GOA:P39580" /db_xref="InterPro:IPR004299" /db_xref="InterPro:IPR024024" /db_xref="InterPro:IPR024194" /db_xref="SubtiList:BG10550" /db_xref="UniProtKB/Swiss-Prot:P39580" /translation="MTPYSSFLFFILLGILLLPTIILGLNGKRFQAYNMFISIIILAL IFSHDLHGVIALCLFTIWQVLLISGYLAYRQKANSGFVFCGAVIASILPLFLSKIWPF LSHPQPHHPPHNLISFLGISYLTFKGVQLIMEARDGLLKEQLPLHRLLYFILFFPTIS SGPIDRYRRFVKDEQKAWTKEEYADLLYTGIHKIFIGFLYKFIIGYAINTYFIMNLPA ITHNKILGNLLYMYGYSMYLFFDFAGYTMFAVGVSYIMGIKSPENFNKPFISKNIKDF WNRWHMSLSFWFRDYVFMRFVFWMTKKKWIKNRMAVSNIGYFLLFMLMGVWHGLAPQY IIYGLYHAVLMTCYNFFEKWNKKYKWLPSNRWTTILAIVITFHFVCFGFYIFSGKPFH HHH*" /label="dltB CDS" gene 3424073..3425260 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /label="dltB gene" CDS 3425277..3425513 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 26193422" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 26193422; Product type c: carrier" /codon_start=1 /transl_table=11 /product="D-alanyl carrier protein" /protein_id="NP_391731.1" /db_xref="EnsemblGenomes-Gn:BSU38520" /db_xref="EnsemblGenomes-Tr:CAB15878" /db_xref="GOA:P39579" /db_xref="InterPro:IPR003230" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:4BPF" /db_xref="PDB:4BPG" /db_xref="PDB:4BPH" /db_xref="SubtiList:BG10549" /db_xref="UniProtKB/Swiss-Prot:P39579" /translation="MDFKQEVLDVLAEVCQDDIVKENPDIEIFEEGLLDSFGTVELLL AIENRFDILVPITEFDRDVWNTPNNIVNQLSELK*" /label="dltC CDS" gene 3425277..3425513 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /label="dltC gene" CDS 3425513..3426691 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 17263852, 17600057, 23858088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine from undecaprenylphosphate tothe polyglycerolphosphate chain for lipoteichoic acid andwall teichoic acid synthesis" /protein_id="NP_391732.1" /db_xref="EnsemblGenomes-Gn:BSU38530" /db_xref="EnsemblGenomes-Tr:CAB15879" /db_xref="GOA:P39578" /db_xref="InterPro:IPR006998" /db_xref="InterPro:IPR023896" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG10548" /db_xref="UniProtKB/Swiss-Prot:P39578" /translation="MKKRFFGPIILAFILFAGAIAIPSSWLTGFITDKRVKESATALN PSMFQGLYLQDQMLKDPTYLPIYGSSELSRLDEFHPSNYFQVNNEGFTPYLVGKGGSQ SLIHSLNFAAHMDQLKGKKIVFIVSPQWFIKRGSDEQHFAPNYSALQGLDLAFNDQID PEIKKKMMKRMLRFKAVQNDAILSELYKAMVNGQTWKVNALKPAAKVYYSMLEKKDLY YSTTESSGPKRYISQSVKDKSWSELNKLADQSGKRHSGSNDFHIDNPVYKKLKPKVPK LKGKNKGRSYAVSPEYGDFEMMLDILKDAGAEPMFVTIPVNGKWYDYTGFPKKGRTDY YKKVNKQIRAKGFQVADFSGHEYDPYFMKDTIHIGWKGWVYVDKAIDEFYKTGKVTSS *" /label="dltD CDS" gene 3425513..3426691 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /label="dltD gene" S_feature 3426692..3426781 /Source="Nicolas_S_feature" /locus_tag="new_3956402_3956491" /HighExp="Paraq, H2O2, Oxctl, LBGexp, Lbexp, dia0, C30, Cold, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1480" CDS 3426782..3427540 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7797557, 14665680; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391733.2" /db_xref="EnsemblGenomes-Gn:BSU38540" /db_xref="EnsemblGenomes-Tr:CAB15880" /db_xref="GOA:P39577" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10547" /db_xref="UniProtKB/Swiss-Prot:P39577" /translation="MKMTNNTVLITGGSAGIGLELAKRLLELGNEVIICGRSEARLAE AKQQLPNIHTKQCDVADRSQREALYEWALKEYPNLNVLVNNAGIQKEIDFKKGTEELF VDGDEIELNFQAPVHLSALFTPHLMKQPEAAIVQVTSGLAFNPLAVYPVYCATKAALH SFSLTLRHQLRDTSVEVIEMAPPMVDTGLNQKSRDKQGLTYRGISSEEYVQYFLDGLK EGKQEITNERVEGLRDATRADYDRLFEQMNTQEN*" /label="dltE CDS" gene 3426782..3427540 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /label="dltE gene" downshifts 3427508 /Source="Nicolas_upshifts" /id="D1997" /incds=0 /nref=48 /ntot=172 /MaxReadThrough="5.94016" /MaxDrop="4.72547" /score="22.6844301" /energy="-13.7" /TU="U3035" /idTUdmin="U3035" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature complement(3427542..3428769) /Source="Nicolas_S_feature" /locus_tag="new_3957252_3958479_c" /HighExp="T0.30H, T1.0H, T1.30H, C30, B60, T2.0H, C90, Gly, T2.30H, S8" /AntisenseName="ilvK" /AntisenseCor="-0.12928749136401099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1481" promotor_-35 3427588..3427595 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3427609..3427628 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3427622 /Source="Nicolas_upshifts" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="upshifts" CDS 3427681..3428772 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 17611193, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 17611193, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid aminotransferase" /protein_id="NP_391734.2" /db_xref="EnsemblGenomes-Gn:BSU38550" /db_xref="EnsemblGenomes-Tr:CAB15881" /db_xref="GOA:P39576" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10546" /db_xref="UniProtKB/Swiss-Prot:P39576" /translation="MTKQTIRVELTSTKKPKPDPNQLSFGRVFTDHMFVMDYAADKGW YDPRIIPYQPLSMDPAAMVYHYGQTVFEGLKAYVSEDDHVLLFRPEKNMERLNQSNDR LCIPQIDEEQVLEGLKQLVAIDKDWIPNAEGTSLYIRPFIIATEPFLGVAASHTYKLL IILSPVGSYYKEGIKPVKIAVESEFVRAVKGGTGNAKTAGNYASSLKAQQVAEEKGFS QVLWLDGIEKKYIEEVGSMNIFFKINGEIVTPMLNGSILEGITRNSVIALLKHWGLQV SERKIAIDEVIQAHKDGILEEAFGTGTAAVISPVGELIWQDETLSINNGETGEIAKKL YDTITGIQKGAVADEFGWTTEVAALTESK*" /label="ilvK CDS" gene 3427681..3428772 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /label="ilvK gene" downshifts 3428674 /Source="Nicolas_upshifts" /id="D1998" /incds=1 /nref=10 /ntot=90 /MaxReadThrough="6.0829" /MaxDrop="3.1965" /score="32.8755878" /energy="-13.6" /TU="U3035,U3037" /idTUdmin="U3035" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 3428762 /Source="Nicolas_upshifts" /id="D1999" /incds=0 /nref=157 /ntot=264 /MaxReadThrough="2.21106" /MaxDrop="6.83094" /score="32.8755878" /energy="-13.6" /TU="NA" /idTUdmin="U3035" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3428806..3430134) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8990303, 10438772, 22720735, 23874669, 24673833; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-beta-glucosidase" /protein_id="NP_391735.1" /db_xref="EnsemblGenomes-Gn:BSU38560" /db_xref="EnsemblGenomes-Tr:CAB15882" /db_xref="GOA:P46320" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11350" /db_xref="UniProtKB/Swiss-Prot:P46320" /translation="MTKGLKIVTIGGGSSYTPELVEGFIKRYDELPVRELWLVDIPEG EEKLNIVGTLAKRMVEKAGVPIDIHLTLDRRKALKDADFVTTQFRVGLLQARAKDERI PLKYGVIGQETNGPGGLFKGLRTIPVILEIAKDIEELCPNAWLVNFTNPAGMVTEALL RYSNLKKVVGLCNVPIGIKMGVAKALDVDVDRVEVQFAGLNHMVFGLDVFLDGVSVKE QVIEAMGDPKNAMTMKNISGAEWEPDFLKALNVIPCGYHRYYFKTKEMLEHELEASQT EGTRAEVVQKVEKELFELYKDPNLAIKPPQLEKRGGAYYSDAACNLISSIYNDKHDIQ PVNTINNGAIASIPDDSAVEVNCVMTKTGPKPIAVGDLPVSVRGLVQQIKSFERVAAE AAVTGDYQTALLAMTINPLVPSDTVAKQILDEMLEAHKAYLPQFFNKIEA*" /label="licH CDS" gene complement(3428806..3430134) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /label="licH gene" downshifts complement(3428814) /Source="Nicolas_upshifts" /id="D2000" /incds=0 /nref=12 /ntot=98 /MaxReadThrough="4.92442" /MaxDrop="6.75565" /score="45.1562234" /energy="-15.7" /TU="U3038" /idTUdmin="U3038" /TUdmin="-152" /isTUend="FALSE" /label="downshifts" CDS complement(3430131..3430463) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIA component" /protein_id="NP_391736.1" /db_xref="EnsemblGenomes-Gn:BSU38570" /db_xref="EnsemblGenomes-Tr:CAB15883" /db_xref="GOA:P46319" /db_xref="InterPro:IPR003188" /db_xref="InterPro:IPR036542" /db_xref="SubtiList:BG11349" /db_xref="UniProtKB/Swiss-Prot:P46319" /translation="MNEEMEQIIFQIILHGGNGRSSAMEAIAAAKSGDAEEARKKLQD AAEELSKAHHYQTELIQNEAGGEKTEMTLLMVHAQDHLMNAMTVKDMAAEIIELYEKI TEQRGASI*" /label="licA CDS" gene complement(3430131..3430463) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /label="licA gene" CDS complement(3430482..3431840) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIC component" /protein_id="NP_391737.1" /db_xref="EnsemblGenomes-Gn:BSU38580" /db_xref="EnsemblGenomes-Tr:CAB15884" /db_xref="GOA:P46317" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG11348" /db_xref="UniProtKB/Swiss-Prot:P46317" /translation="MNKVNQILEEKVMPIAGRIAGQRHLQALRDGIILTMPLIIIGSF FLIIGNLPIPGYAEFMAKTFGSSWSEKLAYPVDATFEIMGLVAAFGIAYRLAEKYGVD ALSAGAISLAAFLLATPYQVPFMPDGATKEIMVGGGIPLSLMGSKGLFVAMIIAMVST EIYRLIIQRNLVFKMPDGVPPAVSKSFVALIPGFAVIFLIWAARLIVEATPFESLHNI VSVLLGTPLSILGGSLGGSLVAEAVKMLLWACGLHGANIVGGVMAPIWYGAMDANRIA FQAGEELPKIFTQQFFDIWVNIGGSGATLALVVTMFLRARSKQMKQLGKLAVGPAIFN INEPIIFGMPIVMNPMLLLPFIITPLVTVTLTYIGMSTGLVAKPAGIAVPWTMPPIFS GYLATGGKVSGAVMQAINIAVSFVVYYPFFRMWDKQKLKEENDLELVQTPAATDDKEA AL*" /label="licC CDS" gene complement(3430482..3431840) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /label="licC gene" CDS complement(3431856..3432164) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 23874669; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIB component" /protein_id="NP_391738.1" /db_xref="EnsemblGenomes-Gn:BSU38590" /db_xref="EnsemblGenomes-Tr:CAB15885" /db_xref="GOA:P46318" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR013012" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11347" /db_xref="UniProtKB/Swiss-Prot:P46318" /translation="MNILLVCAAGMSTSLLVSKMEKSAQEQGKDYTIWAVSGDSVQNH IDKADVLLLGPQVRYMLPQLKKLGESKGVPVDVINTVHYGTCNGAEVLKSAEQLGHVS *" /label="licB CDS" gene complement(3431856..3432164) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /label="licB gene" promotor_-10 complement(3432209..3432228) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3432225) /Source="Nicolas_upshifts" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3432242..3432248) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3432293) /Source="Nicolas_upshifts" /id="D2001" /incds=0 /nref=3 /ntot=74 /MaxReadThrough="3.19679" /MaxDrop="2.70222" /score="27.6067633" /energy="-11.1" /TU="U3040" /idTUdmin="U3040" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" CDS complement(3432293..3434218) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 9353933, 10438772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 9353933, 10438772; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the lichenan operon" /protein_id="NP_391739.1" /db_xref="EnsemblGenomes-Gn:BSU38600" /db_xref="EnsemblGenomes-Tr:CAB15886" /db_xref="GOA:P46321" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG11346" /db_xref="UniProtKB/Swiss-Prot:P46321" /translation="MLHGRLRDILRLLMAAEAPVTSSFFAAQLNVTTRTVRNDIKELQ GVLSGHGAFVQSVRGSGYKLRIDDEQVFRTLLQDEFQQKKGLPVLPEERMAYLMKRLL LADHYLKLDELAEELFISKSTLQTDLKEVKKRLLPYRIVMETRPNYGFKLRGDEVQMR YCMAEYIVDERETEIDVLNEKADILPKEEIEIIRSAILKKMKNDRIPLSNMGLNNLII HIAIACKRIRTENYVSLFPKDMDHILHQKEYQAAEAIVKELESKLSVTFPKDETAYIT MHLLGTKRMTQSQCGEDTFSIEEETDQLTLAMIKAVDRELKLGILHDKELKIGLALHM KPAISRNRYGMNLRNPMLAAIKEHYPLAFEAGIIAGIVIKEQTGIEIHENEIGYLALH FGAAIERKKTESPPKRCIIVCASGAGSAQLLREKLRSHFGKRLDILGTAEYYSLDQMS YESIDFVISTIPIKKELPVPVLKVNTILGGTDFTKIESILSDEKEKANRYLKKELVFF QEDLRSKEEVIQFLGQKVVECGFADEEIIDSIFEREDMSPTCFGNLVAIPHPLVPQTK TTFWAVCTLKKPIDWESQRVQFVCLLCVEKENKADLQSMYKLLGSILDDPAAMNQLIK CRSYQELSDVFDQKMLS*" /label="licR CDS" gene complement(3432293..3434218) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /label="licR gene" promotor_-35 3432956..3432965 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3432979..3432998 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3432987 /Source="Nicolas_upshifts" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3434291..3434308) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-10" upshifts complement(3434315) /Source="Nicolas_upshifts" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="upshifts" promotor_-35 complement(3434323..3434330) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-35" CDS complement(3434381..3434539) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391740.1" /db_xref="EnsemblGenomes-Gn:BSU38610" /db_xref="EnsemblGenomes-Tr:CAB15887" /db_xref="SubtiList:BG14169" /db_xref="UniProtKB/Swiss-Prot:O32283" /translation="MVEKKEGRIGALKKMIKTVIKWAPVIYPIVRKIMKDRKASKQKN MSASRTAG*" /label="yxzF CDS" gene complement(3434381..3434539) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /label="yxzF gene" downshifts complement(3434408) /Source="Nicolas_upshifts" /id="D2002" /incds=0 /nref=75 /ntot=208 /MaxReadThrough="0.739420000000001" /MaxDrop="6.4099" /score="27.6067633" /energy="-11.1" /TU="NA" /idTUdmin="U3041" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(3434568..3435158) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /EC_number="3.2.2.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14729667, 27698084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14729667, 27698084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-alkylated purines and hypoxanthine DNA glycosidase" /protein_id="NP_391741.1" /db_xref="EnsemblGenomes-Gn:BSU38620" /db_xref="EnsemblGenomes-Tr:CAB15888" /db_xref="GOA:P94378" /db_xref="InterPro:IPR003180" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036995" /db_xref="SubtiList:BG12555" /db_xref="UniProtKB/Swiss-Prot:P94378" /translation="MTREKNPLPITFYQKTALELAPSLLGCLLVKETDEGTASGYIVE TEAYMGAGDRAAHSFNNRRTKRTEIMFAEAGRVYTYVMHTHTLLNVVAAEEDVPQAVL IRAIEPHEGQLLMEERRPGRSPREWTNGPGKLTKALGVTMNDYGRWITEQPLYIESGY TPEAISTGPRIGIDNSGEARDYPWRFWVTGNRYVSR*" /label="aag CDS" gene complement(3434568..3435158) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /label="aag gene" promotor_-10 complement(3435186..3435204) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3435197) /Source="Nicolas_upshifts" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3435218..3435224) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3435227..3435233 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3435249..3435267 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3435252 /Source="Nicolas_upshifts" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="upshifts" CDS 3435287..3436930 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9393707, 9555886, 10503549, 24123749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9555886, 10503549, 24123749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="major catalase in spores" /protein_id="NP_391742.1" /db_xref="EnsemblGenomes-Gn:BSU38630" /db_xref="EnsemblGenomes-Tr:CAB15889" /db_xref="GOA:P94377" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11945" /db_xref="UniProtKB/Swiss-Prot:P94377" /translation="MKDDHQNKQHQSNAQGSEEAFSHKTSGKNESEDTLTNRQGHPVT DNQNVRTVGNRGPTTLENYDFLEKISHFDRERIPERVVHARGAGAHGYFEAYGSFGDE PISTYTRAKLFQEKGKKTPAFVRFSTVNHGKHSPETLRDPRGFAVKLYTEDGNWDLVG NNLKIFFIRDPLKFPDLVHAFQPDPVTNIQDGERIFDFISQSPEATHMITFLFSPWGI PANYRQMQGSGVHAYKWVNEEGKAVLVKYHFEPKQGIRNLTQKEAEEIQGKNFNHATQ DLYDAIENGDYPEWEVYAQIMSDDEHPELDFDPLDPTKLWYKDDFPWKPIGKLVLNKN PENYHAEVEQASFGTGVLVDGLDFSDDKLLQGRTFAYSDTQRYRVGANYLQLPINSPK KHVATNQEGGQMQYRVDRAEGQNPHVNYEPSIMGGLKEAKQDGKDHTPHVEGDVKREA IDRTNNFGQAGETYRRFTEFERNELITNLVNTLSTCRKEIQDQMIENFTKADPDYGKR VAEGLKKVSENNSNGPIGTTETEQAAKQAEQESHPSDPY*" /label="katX CDS" gene 3435287..3436930 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /label="katX gene" S_feature complement(3435424..3436973) /Source="Nicolas_S_feature" /locus_tag="new_3965134_3966683_c" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T3.0H, S8, T3.30H, S6, T0.0H" /AntisenseName="katX" /AntisenseCor="0.28909015498211399" /AntisenseRegPval="-5.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1482" downshifts 3436925 /Source="Nicolas_upshifts" /id="D2003" /incds=0 /nref=28 /ntot=49 /MaxReadThrough="0.942820000000001" /MaxDrop="5.69337" /score="45.0252072" /energy="-12.7" /TU="NA" /idTUdmin="U3042" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3436975..3437066) /Source="Nicolas_S_feature" /locus_tag="new_3966685_3966776_c" /HighExp="T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, T3.30H, T4.0H, T3.0H, T0.0H, T5.0H" /AntisenseName="yxlH" /AntisenseCor="-4.8005444617814199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1483" promotor_-35 3436977..3436983 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3436991 /Source="Nicolas_upshifts" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3436998..3437017 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3437018) /Source="Nicolas_upshifts" /id="D2004" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="3.81662" /MaxDrop="3.1285" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1557" /isTUend="FALSE" /label="downshifts" CDS 3437035..3438237 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391743.1" /db_xref="EnsemblGenomes-Gn:BSU38640" /db_xref="EnsemblGenomes-Tr:CAB15890" /db_xref="GOA:P94376" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12554" /db_xref="UniProtKB/Swiss-Prot:P94376" /translation="MELQQDLIPQKKTIGALDHAVFLCMVFCFWFSGYIYVPVFSLYL EDLHFSYGAIGIILGSYGVTQILLRFPLGLLSDILFSLRKQLLIAGFGFSVLSSLLFL MFDSFFFVLAARLFAGITASTWVMATILYAHYFNNGNASKAMGIMQFFTVMPQFASIV FCGLAAAHLGRQVPFWMALAASAAGLVICCFIQDPSAPPANRGTIRVNQYIKDTLRLP KLKLFTILSMTAHAVLFITVFGFTPLYMNQLGMGDAELLWVMSAFFLPHAAATLSFVF LRFTSRIAYSVMLISFAVTGVCLLYVPFLAALFTVCITHACIGLALGFVFPLLLSHVV EISSARLKMSVMGFYQSFYALGIFLGPLLAGKIAQLIGLAGVFYGAGSLAFAAFFVML AQKRNMIN*" /label="yxlH CDS" gene 3437035..3438237 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /label="yxlH gene" S_feature complement(3437068..3438233) /Source="Nicolas_S_feature" /locus_tag="new_3966778_3967943_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T0.0H, T3.0H, T3.30H, T-0.40H, T4.0H" /AntisenseName="yxlH" /AntisenseCor="-4.5703316381945601E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1484" downshifts complement(3437111) /Source="Nicolas_upshifts" /id="D2005" /incds=1 /nref=3 /ntot=61 /MaxReadThrough="6.44992" /MaxDrop="2.92619" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1650" /isTUend="FALSE" /label="downshifts" CDS complement(3438234..3439010) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC-transporter (permease)" /protein_id="NP_391744.2" /db_xref="EnsemblGenomes-Gn:BSU38650" /db_xref="EnsemblGenomes-Tr:CAB15891" /db_xref="GOA:P94375" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12553" /db_xref="UniProtKB/Swiss-Prot:P94375" /translation="MKVMMALLQKEWLEGWKSGKLIWLPIAMMIVGLTQPLTIYYMPE IIAHGGNLPDGMKISFTMPSGSEVMVSTLSQFNTLGMALVIFSVMGSVANERNQGVTA LIMSRPVTAAHYIVSKWLIQSVIGIMSFAAGYGLAYYYVRLLFEDASFSRFAASLGLY ALWVIFIVTAGLAGSTIFRSVGAAAACGIGLTAAVSFAVSLFPDGAKWLPAEICKQAE HILLHGERADFFGWSLTFSILCIMLLAVFSVWRFRRYESY*" /label="yxlG CDS" gene complement(3438234..3439010) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /label="yxlG gene" CDS complement(3439007..3439894) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter component (ATP-binding protein)" /protein_id="NP_391745.1" /db_xref="EnsemblGenomes-Gn:BSU38660" /db_xref="EnsemblGenomes-Tr:CAB15892" /db_xref="GOA:P94374" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12552" /db_xref="UniProtKB/Swiss-Prot:P94374" /translation="MLSIESLCKSYRHHEAVKNVSFHVNENECVALLGPNGAGKTTTL QMLAGLLSPTSGTIKLLGEKKLDRRLIGYLPQYPAFYSWMTANEFLTFAGRLSGLSKR KCQEKIGEMLEFVGLHEAAHKRIGGYSGGMKQRLGLAQALLHKPKFLILDEPVSALDP TGRFEVLDMMRELKKHMAVLFSTHVLHDAEQVCDQVVIMKNGEISWKGELQELKQQQQ TNVFTLSVKEKLEGWLEEKPYVSAIVYKNPSQAVFELPDIHAGRSLLSDCIRKGLTVT RFEQKTESLEDVYLKVVHA*" /label="yxlF CDS" gene complement(3439007..3439894) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /label="yxlF gene" CDS complement(3439901..3440089) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma-Y activity" /protein_id="NP_391746.1" /db_xref="EnsemblGenomes-Gn:BSU38670" /db_xref="EnsemblGenomes-Tr:CAB15893" /db_xref="GOA:P94373" /db_xref="InterPro:IPR027379" /db_xref="SubtiList:BG12551" /db_xref="UniProtKB/Swiss-Prot:P94373" /translation="MNISWEMILPLIVLQLALAVFALISCIKEERTNGPKWMWAAIIV CINIIGPILFFTVGRKQR*" /label="yxlE CDS" gene complement(3439901..3440089) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /label="yxlE gene" CDS complement(3440086..3440292) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative sigma-Y antisigma factor component" /protein_id="NP_391747.1" /db_xref="EnsemblGenomes-Gn:BSU38680" /db_xref="EnsemblGenomes-Tr:CAB15894" /db_xref="GOA:P94372" /db_xref="SubtiList:BG12550" /db_xref="UniProtKB/Swiss-Prot:P94372" /translation="MTQTEIIITVAACLIVLAQGIFLFIDAKKRNHMAWVWGIVGLIQ APMPLICYYFFVIRPDRKKRGIKQ*" /label="yxlD CDS" gene complement(3440086..3440292) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /label="yxlD gene" CDS complement(3440289..3440609) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sigma-Y antisigma factor" /protein_id="NP_391748.1" /db_xref="EnsemblGenomes-Gn:BSU38690" /db_xref="EnsemblGenomes-Tr:CAB15895" /db_xref="GOA:P94371" /db_xref="InterPro:IPR035238" /db_xref="SubtiList:BG12549" /db_xref="UniProtKB/Swiss-Prot:P94371" /translation="MNKEKLSDHLKSEWKKIDQTANPSIPNQKELLHQLSQMKAEYRK KLLQEIILFVFCALMVVSAAILAFTQAPAVFIVLQVCVLAVLPILIAAEKKRHLGECE VKRG*" /label="yxlC CDS" gene complement(3440289..3440609) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /label="yxlC gene" promotor_-35 3440422..3440431 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3440444..3440463 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3440446 /Source="Nicolas_upshifts" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3440602..3441138) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma-Y)" /protein_id="NP_391749.1" /db_xref="EnsemblGenomes-Gn:BSU38700" /db_xref="EnsemblGenomes-Tr:CAB15896" /db_xref="GOA:P94370" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11975" /db_xref="UniProtKB/Swiss-Prot:P94370" /translation="MDTQEEQRLIQQAKEGNDEAFTALFHYHYSFLYKYLLKLSLHPD LSEELVQETFLKGYIHLRSFQGRSKFSTWLISIASRLYLDHQKKRKREWKRNQTVTEE TIRKIKWDVSAKGAEWSETLDLFSKLDPKLRTPVLLRHYYGYTYAEIGVMLQIKEGTV KSRVHKGLQQIRKEWDDE*" /label="sigY CDS" gene complement(3440602..3441138) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /label="sigY gene" upshifts complement(3441166) /Source="Nicolas_upshifts" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3441167..3441182) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3441194..3441203) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3441269..3441276 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3441290..3441309 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3441299 /Source="Nicolas_upshifts" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="upshifts" CDS 3441350..3442723 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2191181, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine-cytosine (pyridoxine) permease" /protein_id="NP_391750.1" /db_xref="EnsemblGenomes-Gn:BSU38710" /db_xref="EnsemblGenomes-Tr:CAB15897" /db_xref="GOA:P94369" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR026030" /db_xref="SubtiList:BG12548" /db_xref="UniProtKB/Swiss-Prot:P94369" /translation="MKVERRTIEYIPNEERHGKAKDLFPVWFGANMHITTLVTGTIPV AMGLNLFWSVAAIICGTLIGAIFMASHSAQGPQLGIPQMIQSRAQFGVIGAILPLFLV MFIYLGFFASSTILAAGTLSSFVPIPGSWSIIGLSAVCFLLTIFGHDLIHKMQKILSW TSFAVFFAATILIFQLPIPAGSWIPGAIDLPIFLVAVSAVATWQLAYAPYVADYSRYL PVKTPASKTFWYSYAGTSVSSIWMMLLGALLTTSLPDFTANSGSQIVQLFGPFSFIML IIVLFGQMAINVFNLYGAFMSTTTTLEPFLKLKVTPKVRIIMILGVTLVGTVLSLLGQ SNFMELFLNFIFFISYFLIPWTAINLVDYYFVRHGKYQVKAMFDVNGPYGKVNWITTI AFVLSILLEIPFINTSFYIGPLAKMFGGGDIAWIIGLAVPSVLYYVLMKPRLKKRAGY QEKLSSL*" /label="yxlA CDS" gene 3441350..3442723 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /label="yxlA gene" S_feature complement(3441630..3442172) /Source="Nicolas_S_feature" /locus_tag="new_3971340_3971882_c" /HighExp="Etha, LBGstat, T1.0H, T0.30H, Diami, T1.30H, dia15, G150, G135, G180" /AntisenseName="yxlA" /AntisenseCor="-8.6586358833710395E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1485" promotor_-10 complement(3442160..3442179) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3442172) /Source="Nicolas_upshifts" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3442194..3442201) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3442558 /Source="Nicolas_upshifts" /id="D2006" /incds=1 /nref=30 /ntot=136 /MaxReadThrough="1.87017" /MaxDrop="3.59478" /score="22.3054019" /energy="-12.9" /TU="NA" /idTUdmin="U3046" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3442738..3443568) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12457846, 21994945, 22940582, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12457846, 21994945, 22940582, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H dehydratase" /protein_id="NP_391751.1" /db_xref="EnsemblGenomes-Gn:BSU38720" /db_xref="EnsemblGenomes-Tr:CAB15898" /db_xref="GOA:P94368" /db_xref="InterPro:IPR000631" /db_xref="InterPro:IPR017953" /db_xref="InterPro:IPR029056" /db_xref="PDB:1KYH" /db_xref="PDB:3RPH" /db_xref="PDB:3RPZ" /db_xref="PDB:3RQ2" /db_xref="PDB:3RQ5" /db_xref="PDB:3RQ6" /db_xref="PDB:3RQ8" /db_xref="PDB:3RQH" /db_xref="PDB:3RQQ" /db_xref="PDB:3RQX" /db_xref="SubtiList:BG12547" /db_xref="UniProtKB/Swiss-Prot:P94368" /translation="MNVPFWTEEHVRATLPERDAESHKGTYGTALLLAGSDDMPGAAL LAGLGAMRSGLGKLVIGTSENVIPLIVPVLPEATYWRDGWKKAADAQLEETYRAIAIG PGLPQTESVQQAVDHVLTADCPVILDAGALAKRTYPKREGPVILTPHPGEFFRMTGVP VNELQKKRAEYAKEWAAQLQTVIVLKGNQTVIAFPDGDCWLNPTGNGALAKGGTGDTL TGMILGMLCCHEDPKHAVLNAVYLHGACAELWTDEHSAHTLLAHELSDILPRVWKRFE *" /label="nnrA CDS" gene complement(3442738..3443568) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /label="nnrA gene" downshifts complement(3442744) /Source="Nicolas_upshifts" /id="D2007" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="3.50755" /MaxDrop="3.84264" /score="7.61210868" /energy="-12.9" /TU="U3048" /idTUdmin="U3051" /TUdmin=792 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3443587..3443605) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3443602) /Source="Nicolas_upshifts" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3443620..3443626) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3443646) /Source="Nicolas_upshifts" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3443648..3443667) /Source="Nicolas_upshift_promotors" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3443654..3445381) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391752.1" /db_xref="EnsemblGenomes-Gn:BSU38730" /db_xref="EnsemblGenomes-Tr:CAB15899" /db_xref="GOA:P94367" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014223" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11928" /db_xref="UniProtKB/Swiss-Prot:P94367" /translation="MKKEEWILPYIKQNARLFVLVIFLGAVTIFSAAFLMFTSGFLIS KAATRPENILLIYVPIVAVRTFGIARSVSRYVERLVGHHIILKIVSDMRVRLYNMLEP GALMLRSRFRTGDMLGILSEDIEHLQDAFLKTIFPAISALLLYAVSVIALGFFSWPFA ILLALYLFVLVVLFPVVSLLVTRAKNAKLKSGRNVLYSRLTDAVMGVSDWMFSGRRHA FIDAYEKEERDWFELERKKQRFTRWRDFAAQCLVAGLILLMLFWTAGQQADGELAKTM IAAFVLVVFPLTEAFLPLSDALGEVPGYQDSIRRMNNVAPQPEASQTESGDQILDLQD VTLAFRDVTFSYDNSSQVLHNFSFTLRQGEKMALLGRSGSGKSTSLALIEGALKPDSG SVTLNGVETALLKDQIADAVAVLNQKPHLFDTSILNNIRLGNGEASDEDVRRAAKQVK LHDYIESLPDGYHTSVQETGIRFSGGERQRIALARILLQDTPIIILDEPTVGLDPITE RELMETVFEVLKGKTILWITHHLAGVEAADKIVFLENGKTEMEGTHEELLAANERYRR LYHLDVPVK*" /label="cydD CDS" gene complement(3443654..3445381) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /label="cydD gene" downshifts complement(3443753) /Source="Nicolas_upshifts" /id="D2008" /incds=1 /nref=7 /ntot=46 /MaxReadThrough="5.39758" /MaxDrop="3.66431" /score="25.0271963" /energy="-10.6" /TU="U3051" /idTUdmin="U3051" /TUdmin="-217" /isTUend="FALSE" /label="downshifts" CDS complement(3445378..3447081) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391753.1" /db_xref="EnsemblGenomes-Gn:BSU38740" /db_xref="EnsemblGenomes-Tr:CAB15900" /db_xref="GOA:P94366" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014216" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11927" /db_xref="UniProtKB/Swiss-Prot:P94366" /translation="MGKDLFRYKGMKRILTLITCLTLIQTAAIIMQAEWLSEAVTGLF NGKGITSLLPVIGFFLIAFIARHGMTVARQKIVYQYAARTGADLRKSFLDQLFRLGPR FAKKEGTGQMVTLAMEGISQFRRYLELFLPKMVSMAIVPAAVVIYVFFQDRTSAIILV AAMPILIIFMILLGLVAQRKADRQWKSYQRLSNHFVDSLRGLETLRFLGLSKSHSKNI FYVSERYRKATMSTLRVAFLSSFALDFFTMLSVATVAVFLGLRLIDGDILLGPALTAL ILAPEYFLPVREVGNDYHATLNGQEAGKTIQEILSQPGFKEETPLQLEAWSDQDELKL SGVSVGRSVSDIHLSFKGKKKIGIIGASGAGKSTLIDILGGFLEPDGGMIEVNGTSRS HLQDGSWQKNLLYIPQHPYIFDDTLGNNIRFYHPSASAEDTTRAAASAGLTELVNNLP DGLEGRIGEGGRALSGGQAQRVALARAFLGNRPILLLDEPTAHLDIETEYEIKETMLD LFEDKLVFLATHRLHWMLDMDEIIVLDGGRVAEIGTHNELLEKNGVYTKLVKAQLGER A*" /label="cydC CDS" gene complement(3445378..3447081) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /label="cydC gene" CDS complement(3447081..3448097) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit II)" /protein_id="NP_391754.1" /db_xref="EnsemblGenomes-Gn:BSU38750" /db_xref="EnsemblGenomes-Tr:CAB15901" /db_xref="GOA:P94365" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG11926" /db_xref="UniProtKB/Swiss-Prot:P94365" /translation="MASLHDLWFILVAVLFVGFFFLEGFDFGVGMATRFLGHNELERR VLINTIGPFWDANEVWLLTGAGAIFAAFPNWYATMLSGYYIPFVIVLLALMGRGVAFE FRGKVDHLKWVKVWDWVVFFGSLIPPFVLGVLFTTLFRGMPIDADMNIHAHVSDYINV YSILGGVTVTLLCFQHGLMFITLRTIGDLQNRARKMAQKIMGVVFVAVLAFAALSAYQ TDMFTRRGEITIPLAVLIVICFMLAAVFIRKKKDGWTFGMTGAGLALTVGMIFISLFP RVMVSSLHSAYDLTVANASSGDYSLKVMSIAALTLLPFVIGSQIWSYYVFRKRVSHKE PMTY*" /label="cydB CDS" gene complement(3447081..3448097) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /label="cydB gene" promotor_-10 complement(3447971..3447989) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3447980) /Source="Nicolas_upshifts" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3448005..3448010) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3448081..3449487) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit I)" /protein_id="NP_391755.1" /db_xref="EnsemblGenomes-Gn:BSU38760" /db_xref="EnsemblGenomes-Tr:CAB15902" /db_xref="GOA:P94364" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG11925" /db_xref="UniProtKB/Swiss-Prot:P94364" /translation="MSELVLARIQFASTTLFHFLFVPMSIGLVFMVALMETLYLVKKN ELYLKMAKFWGHLFLINFAVGVVTGILQEFQFGLNWSDYSRFVGDVFGAPLAIEALLA FFMESIFIGLWIFGWDRLPKKIHALCIWLVSFGTIMSSFWILTANSFMQEPVGFTIKN GRAEMNDFGALITNPQLWVEFPHVIFGALATGAFFIAGVSAFKLLKKKEVPFFKQSFK LAMIVGLCAGLGVGLSGHMQAEHLMESQPMKMAASEGLWEDSGDPAAWTAFATIDTKN EKSSNEIKVPYALSYLAYQKFSGSVKGMKTLQAEYEKIYGKGDYIPPVKTTFWSFRIM VGAGVVMILAALGGLWLNRRKKLENSKWYLRIMIALISFPFLANSAGWIMTEIGRQPW TVMGLMTTAQSVSPNVTAGSLLFSIIAFGVMYMILGALLVFLFIREIKKGAEHDNHHD VPVSTDPFSQEVYHGISS*" /label="cydA CDS" gene complement(3448081..3449487) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /label="cydA gene" S_feature complement(3449488..3449696) /Source="Nicolas_S_feature" /locus_tag="new_3979198_3979406_c" /HighExp="M0t45, ferm, UNK1, Gly, Lbexp, Lbstat, dia0, nit, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1486" promotor_-10 complement(3449679..3449698) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3449696) /Source="Nicolas_upshifts" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3449698..3449806) /Source="Nicolas_S_feature" /locus_tag="new_3979408_3979516_c" /HighExp="LPhT, LBGtran, ferm, LBGstat, M0t45, dia0, Etha, dia5, Lbexp, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1487" promotor_-35 complement(3449712..3449717) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3449803..3449822) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-10" upshifts complement(3449818) /Source="Nicolas_upshifts" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="upshifts" promotor_-35 complement(3449836..3449843) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-35" promotor_-35 3449964..3449971 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3449981 /Source="Nicolas_upshifts" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3449986..3450004 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3450043..3451395 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11566984, 12525174, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11566984, 12525174, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="citrate/malate/H+ symporter" /protein_id="NP_391756.1" /db_xref="EnsemblGenomes-Gn:BSU38770" /db_xref="EnsemblGenomes-Tr:CAB15903" /db_xref="GOA:P94363" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12546" /db_xref="UniProtKB/Swiss-Prot:P94363" /translation="MGELQTHMQLQTDTIHEGVRKENWFAKAMNIKVGIIPLPVYALL FILITVFVMHHDVKSDILTSIAVMAFFGFTFAQIGKSIPIVRSIGGPAILATFIPSAV VYYHLLPNDIVKSTTEFTENSNFLYLFIAGIVVGSILGMKRETLVKAFMKIFIPLIVG SVTAAIVGLAVGTLLGLGFQHTLLYIVIPIMAGGVGEGAIPLSIGYSDIMPISQGEAF ALVLPSIMLGSLCAIILAGLLNRIGKKKPEWTGNGKVDRSEEESPALEESQSGQQMFN LSLFASGGILAVSLYLVGMLAHDFFGFPAPVAMLLLAVLIKLFRLVPASIENGAFGVS RFFSTAVTYPLLFAIGVSMTPWDKLVAAFNLSNIITILSVVVTMMAVGFFTGKWLNMY PIETAIINACHSGQGGTGDVAILSAAERLELMPFAQVSTRIGGAITVSLTLLLLHQFY *" /label="cimH CDS" gene 3450043..3451395 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /label="cimH gene" S_feature complement(3450994..3453476) /Source="Nicolas_S_feature" /locus_tag="new_3980704_3983186_c" /HighExp="Cold, C30, LBGstat, Paraq, GM 120, GM 90, H2O2, Oxctl, GM 25, GM 45" /AntisenseName="yxkI" /AntisenseCor="0.564471040461903" /AntisenseRegPval="-23.3" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1488" downshifts 3451380 /Source="Nicolas_upshifts" /id="D2009" /incds=0 /nref=63 /ntot=147 /MaxReadThrough="2.93791" /MaxDrop="3.97692" /score="3.68725156" /energy="-12.7" /TU="U3053" /idTUdmin="U3053" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_feature 3451471..3451490 /Source="Nicolas_upshift_promotors" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3451477 /Source="Nicolas_upshifts" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="upshifts" CDS 3451517..3453205 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /EC_number="3.4.24.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_391757.1" /db_xref="EnsemblGenomes-Gn:BSU38780" /db_xref="EnsemblGenomes-Tr:CAB15904" /db_xref="GOA:P94362" /db_xref="InterPro:IPR001915" /db_xref="SubtiList:BG12545" /db_xref="UniProtKB/Swiss-Prot:P94362" /translation="MPMGTHLFLFMLLGLGFYLISALAAKLIPAIDFWIDIVLWVGAA AYIFSHLSFMDGIVSLATMFYCYWTAMDLIVSERVEKPSGDWQEIELAKNKTRLLSDI TLTAIVFAGAVIFFIYGPDTSPLKYVILLGMISGGGALVKRILNVFSVKVFYSAALEK LHISSHYETRTYPLSDLKNIQLESTADLLKLHPLLTMYSSRLDLTTSFQQVIKLSLPG ETLFLTVKEPQKWKTILQEYTDAENNVDNVISVLPFYHRKNVKRLLGKLYFAASVKGV SAYALLVLALYALHASPWVMAVAVILYWVFNMYMSDRVLRAAMDAKSCHHPHVQAAAD KIFRSAGISHVRIYETESDDYNGMAVGMNVGRSMVILTSATLTLPQRVIEGILAHEAI HIKKRDVLSSQLLRFLYLGAVVGIFLLFEQHITHPEAHKIALWAFIMAIIILFQLYQS FCSQWMEVRADNLGASLLDGGYKQMAEALRILAVRQDEDIQKQSAYSSEAGEDELQID SLTRDKSWFFRLIDFQFAPHPPMYWRVGTLLSNKGHGVLKRWLRDRLKESITLK*" /label="yxkI CDS" gene 3451517..3453205 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /label="yxkI gene" promotor_-35 3453203..3453212 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3453224..3453239 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3453228 /Source="Nicolas_upshifts" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="upshifts" CDS 3453263..3453463 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391758.1" /db_xref="EnsemblGenomes-Gn:BSU38790" /db_xref="EnsemblGenomes-Tr:CAB15905" /db_xref="SubtiList:BG14168" /db_xref="UniProtKB/Swiss-Prot:O32284" /translation="MIVIILLFISIIVFLSVIQPQPSKNKSRQQADSGYFGYSDHSSH HDGCSSDGGFSDSGCGGGGGGD*" /label="yxzE CDS" gene 3453263..3453463 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /label="yxzE gene" S_feature 3453464..3454408 /Source="Nicolas_S_feature" /locus_tag="new_3983174_3984118" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T0.0H, T-0.40H, Salt, T3.30H, T3.0H" /AntisenseName="yxkH" /AntisenseCor="0.147753218660366" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1489" CDS complement(3453477..3454316) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported polysaccharide deacetylase, lipoprotein" /protein_id="NP_391759.1" /db_xref="EnsemblGenomes-Gn:BSU38800" /db_xref="EnsemblGenomes-Tr:CAB15906" /db_xref="GOA:P94361" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG12544" /db_xref="UniProtKB/Swiss-Prot:P94361" /translation="MKRLFLSIFLLGSCLALAACADQEANAEQPMPKAEQKKPEKKAV QVQKKEDDTSAWIKTEKPAKLPILMYHSISSGNSLRVPKKEFEAHMKWLHDNGYQTLT PKEASLMLTQDKKPSEKCVLITFDDGYTDNYQDAYPVLKKYGMKATIFMIGKSIGHKH HLTEEQMKEMAQHGISIESHTIDHLELNGLTPQQQQSEMADSKKLFDNMFHQQTTIIS YPVGRYNEETLKAAEKTGYQMGVTTEPGAASRDQGMYALHRVRVSPGMSGSAFGAYIE SMK*" /label="yxkH CDS" gene complement(3453477..3454316) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /label="yxkH gene" promotor_-10 complement(3454342..3454360) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3454360) /Source="Nicolas_upshifts" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3454373..3454380) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3454375 /Source="Nicolas_upshifts" /id="D2010" /incds=0 /nref=27 /ntot=142 /MaxReadThrough="0.40982" /MaxDrop="6.50242" /score="33.6694147" /energy="-13.4" /TU="NA" /idTUdmin="U3055" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(3454423..3455520) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multiple sugar (maltodextrins) transporter ATP-binding protein" /protein_id="NP_391760.1" /db_xref="EnsemblGenomes-Gn:BSU38810" /db_xref="EnsemblGenomes-Tr:CAB15907" /db_xref="GOA:P94360" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005116" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11954" /db_xref="UniProtKB/Swiss-Prot:P94360" /translation="MAELRMEHIYKFYDQKEPAVDDFNLHIADKEFIVFVGPSGCGKS TTLRMVAGLEEISKGDFYIEGKRVNDVAPKDRDIAMVFQNYALYPHMTVYDNIAFGLK LRKMPKPEIKKRVEEAAKILGLEEYLHRKPKALSGGQRQRVALGRAIVRDAKVFLMDE PLSNLDAKLRVQMRAEIIKLHQRLQTTTIYVTHDQTEALTMATRIVVMKDGKIQQIGT PKDVYEFPENVFVGGFIGSPAMNFFKGKLTDGLIKIGSAALTVPEGKMKVLREKGYIG KEVIFGIRPEDIHDELIVVESYKNSSIKAKINVAELLGSEIMIYSQIDNQDFIARIDA RLDIQSGDELTVAFDMNKGHFFDSETEVRIR*" /label="msmX CDS" gene complement(3454423..3455520) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /label="msmX gene" downshifts complement(3454424) /Source="Nicolas_upshifts" /id="D2011" /incds=0 /nref=81 /ntot=171 /MaxReadThrough="3.31232" /MaxDrop="7.04855" /score="29.2689404" /energy="-14.4" /TU="U3057" /idTUdmin="U3058" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3455553..3455572) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3455570) /Source="Nicolas_upshifts" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3455572..3455640) /Source="Nicolas_S_feature" /locus_tag="new_3985282_3985350_c" /HighExp="M0t90, M40t90, Lbstat, Lbtran, T2.0H, dia5, T2.30H, M9-stat, S2, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1490" promotor_-35 complement(3455585..3455592) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3455641..3456534) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10746760" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10746760; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates yxkF-msmX expression)" /protein_id="NP_391761.1" /db_xref="EnsemblGenomes-Gn:BSU38820" /db_xref="EnsemblGenomes-Tr:CAB15908" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12543" /db_xref="UniProtKB/Swiss-Prot:P94359" /translation="MKSLLAIYPGSIVSEELCIREGCLCFFDESNQRYISIPKTEISE KEVLVLQSFLTPADEGNQLSMKSPEENKWFSFLFSRGELPAYIKKRTRFVHFHLFGKI ERTSFTEAVRHFWPVSFVIVWIHEDRGVIVEQESEAAAEKDELESLAKVLESDFYFSV RFYAGRFYEPDECLRKHYAREQAYFLFAEKRLPQVQSVTFEMIFPFLLLETEKEKLET LLSEEAELLFGSESELRKTIKLFIENNSNVTLTAKKLHLHRNSLQYRIDKFIERSGID IKSYKGALLAYFICLQNESSE*" /label="yxkF CDS" gene complement(3455641..3456534) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /label="yxkF gene" promotor_-10 complement(3456561..3456580) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3456580) /Source="Nicolas_upshifts" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3456594..3456601) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3456608..3456613 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3456629..3456647 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3456638 /Source="Nicolas_upshifts" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3456655..3456661 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3456676..3456694 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3456682 /Source="Nicolas_upshifts" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="upshifts" CDS 3456718..3458175 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391762.1" /db_xref="EnsemblGenomes-Gn:BSU38830" /db_xref="EnsemblGenomes-Tr:CAB15909" /db_xref="GOA:P94358" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="PDB:4DNG" /db_xref="SubtiList:BG11903" /db_xref="UniProtKB/Swiss-Prot:P94358" /translation="MSFETLNKSFINGKWTGGESGRTEDILNPYDQSVITTASLATGK QLEDAFDIAQKAQKEWAKSTTEDRKAVLQKARGYLHENRDDIIMMIARETGGTIIKST IELEQTIAILDEAMTYTGELGGVKEVPSDIEGKTNKIYRLPLGVISSISPFNFPMNLS MRSIAPAIALGNSVVHKPDIQTAISGGTIIAKAFEHAGLPAGVLNVMLTDVKEIGDGM LTNPIPRLISFTGSTAVGRHIGEIAGRAFKRMALELGGNNPFAVLSDADVDRAVDAAI FGKFIHQGQICMIINRIIVHQDVYDEFVEKFTARVKQLPYGDQTDPKTVVGPLINERQ IEKALEIIEQAKTDGIELAVEGKRVGNVLTPYVFVGADNNSKIAQTELFAPIATIIKA GSDQEAIDMANDTEYGLSSAVFTSDLEKGEKFALQIDSGMTHVNDQSVNDSPNIAFGG NKASGVGRFGNPWVVEEFTVTKWISIQKQYRKYPF*" /label="aldY CDS" gene 3456718..3458175 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /label="aldY gene" promotor_-10 complement(3457601..3457619) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3457616) /Source="Nicolas_upshifts" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3457634..3457639) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3458156 /Source="Nicolas_upshifts" /id="D2012" /incds=0 /nref=14 /ntot=39 /MaxReadThrough="1.43471" /MaxDrop="4.03346" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 3458200 /Source="Nicolas_upshifts" /id="D2013" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="1.40793" /MaxDrop="3.07407" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(3458217..3459053) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10735877, 10931887, 15096624, 15849754, 16850406, 21317561; Product type t : transporter" /codon_start=1 /transl_table=11 /product="guanidinium exporter" /protein_id="NP_391763.1" /db_xref="EnsemblGenomes-Gn:BSU38840" /db_xref="EnsemblGenomes-Tr:CAB15910" /db_xref="GOA:P94357" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12542" /db_xref="UniProtKB/Swiss-Prot:P94357" /translation="MKKRMLDVLMLVIGAFFFALAVNLFAIPNDLGEGGVTGITLILY YLFQWSPGVTNFILNAFLLLIGYKFLDGKTTVYTIIAVAANSLFLHLTHGWSIPSDEL IINTIFAGVFAGVGIGMIIRVGGTTAGSAILARIANKYLDWNISYALLFFDLIVVFSS YFIIGAEKMMFTIVMLYIGTKVMDFIIEGLNTKKAITVISENKSEIAEQVNTLMDRGV TILSGKGNYTGQSKEILYIVINKQELSMLKKIIRSCDKKAFVIVHDVRDVFGEGFVDI SK*" /label="gdnE CDS" gene complement(3458217..3459053) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /label="gdnE gene" downshifts complement(3458235) /Source="Nicolas_upshifts" /id="D2014" /incds=0 /nref=19 /ntot=137 /MaxReadThrough="1.00689" /MaxDrop="4.07213" /score="21.5028874" /energy="-13.8" /TU="NA" /idTUdmin="U3062" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" misc_RNA complement(3459130..3459232) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /product="guanidine riboswitch (type I)" /experiment="publication(s) with functional evidences, PMID:21317561, 27989440, 28096518" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21317561, 27989440, 28096518" /label="gdwB RNA" gene complement(3459130..3459232) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /label="gdwB gene" downshifts complement(3459156) /Source="Nicolas_upshifts" /id="D2015" /incds=0 /nref=194 /ntot=247 /MaxReadThrough="3.21415" /MaxDrop="5.58394" /score="-0.190335837" /energy="-10.7" /TU="U3062" /idTUdmin="U3065" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3459258..3459277) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3459269) /Source="Nicolas_upshifts" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3459271..3460012) /Source="Nicolas_S_feature" /locus_tag="new_3988981_3989722_c" /HighExp="S6, S8, S7, C30, S5, Gly, C90, Fru, BT, Pyr" /AntisenseName="yxkC" /AntisenseCor="-0.38162570069976298" /AntisenseRegPval="-10" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1491" promotor_-35 complement(3459291..3459297) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3459349..3459356 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3459369..3459387 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3459378 /Source="Nicolas_upshifts" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="upshifts" S_feature 3459388..3459473 /Source="Nicolas_S_feature" /locus_tag="new_3989098_3989183" /HighExp="Cold, SMM, MG 150, GM 90, Glu, C30, GM 150, GM-0.2, GM 15, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1492" promotor_-35 3459449..3459456 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3459470..3459489 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3459475 /Source="Nicolas_upshifts" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="upshifts" CDS 3459621..3460163 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818, 15033535" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391764.2" /db_xref="EnsemblGenomes-Gn:BSU38850" /db_xref="EnsemblGenomes-Tr:CAB15911" /db_xref="GOA:P94356" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="SubtiList:BG12541" /db_xref="UniProtKB/Swiss-Prot:P94356" /translation="MRHKIITFILAVVVIIIIGNMIGGGGGSEATSKTSSSSKAETEK TYNIGDTVKTEKTEVTVTKVEDRDTVGTQYVEKKASEGGTIVAVQYTIKNVSKKPISS FSIPTVKLVDADGTSYDSDIDASVNYATETKVDNSKILSDLNPNIKVTGVKAFEVDKE AYAKGTWKLKFSNDVIVKIK*" /label="yxkC CDS" gene 3459621..3460163 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /label="yxkC gene" promotor_-10 complement(3459988..3460007) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3460012) /Source="Nicolas_upshifts" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3460021..3460030) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3460153 /Source="Nicolas_upshifts" /id="D2016" /incds=0 /nref=78 /ntot=276 /MaxReadThrough="4.33141" /MaxDrop="6.78221" /score="9.28209494" /energy="-14.4" /TU="U3063,U3064" /idTUdmin="U3064" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" S_feature 3460198..3460520 /Source="Nicolas_S_feature" /locus_tag="new_3989908_3990230" /HighExp="Cold, C30, Heat, Fru, Glu, C90, BMM, Glucon, M/G, Mal" /AntisenseName="galE" /AntisenseCor="0.165797390333391" /AntisenseRegPval="-2.2000000000000002" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1493" CDS complement(3460238..3461257) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /EC_number="5.1.3.7" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1906927, 9555917, 14597172" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906927, 9555917, 14597172; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 4-epimerase" /protein_id="NP_391765.1" /db_xref="EnsemblGenomes-Gn:BSU38860" /db_xref="EnsemblGenomes-Tr:CAB15912" /db_xref="GOA:P55180" /db_xref="InterPro:IPR005886" /db_xref="InterPro:IPR008089" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11837" /db_xref="UniProtKB/Swiss-Prot:P55180" /translation="MAILVTGGAGYIGSHTCVELLNSGYEIVVLDNLSNSSAEALNRV KEITGKDLTFYEADLLDREAVDSVFAENEIEAVIHFAGLKAVGESVAIPLKYYHNNLT GTFILCEAMEKYGVKKIVFSSSATVYGVPETSPITEDFPLGATNPYGQTKLMLEQILR DLHTADNEWSVALLRYFNPFGAHPSGRIGEDPNGIPNNLMPYVAQVAVGKLEQLSVFG NDYPTKDGTGVRDYIHVVDLAEGHVKALEKVLNSTGADAYNLGTGTGYSVLEMVKAFE KVSGKEVPYRFADRRPGDIATCFADPAKAKRELGWEAKRGLEEMCADSWRWQSSNVNG YKSAE*" /label="galE CDS" gene complement(3460238..3461257) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /label="galE gene" downshifts complement(3460256) /Source="Nicolas_upshifts" /id="D2017" /incds=0 /nref=235 /ntot=261 /MaxReadThrough="1.7919" /MaxDrop="7.32805" /score="24.6899971" /energy="-14.8" /TU="NA" /idTUdmin="U3066" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3461283..3461302) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3461297) /Source="Nicolas_upshifts" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3461317..3461320) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3461372..3461878) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phospholipid binding protein" /protein_id="NP_391766.1" /db_xref="EnsemblGenomes-Gn:BSU38870" /db_xref="EnsemblGenomes-Tr:CAB15913" /db_xref="InterPro:IPR005247" /db_xref="InterPro:IPR008914" /db_xref="InterPro:IPR036610" /db_xref="SubtiList:BG11899" /db_xref="UniProtKB/Swiss-Prot:P55185" /translation="MNIYVEANPYLHDKYSKYADEKYKREGNPFVSFPIHFDDIPSGA KTLALTFIDHDAIPVCGFSWIHWTAANIPAYIGELPEHASEERQDLMIQGQNSFASPL AGSNDPKVIHQYCGPTPPDKDHAYTLTVYALDAELNLQPGFYLNELYQEMKEHILAET SIELLARV*" /label="yxkA CDS" gene complement(3461372..3461878) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /label="yxkA gene" promotor_-10 complement(3461884..3461903) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3461906) /Source="Nicolas_upshifts" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3461908..3461911 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3461917..3461923) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3461926..3461945 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3461929 /Source="Nicolas_upshifts" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="upshifts" CDS 3462008..3462883 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391767.1" /db_xref="EnsemblGenomes-Gn:BSU38880" /db_xref="EnsemblGenomes-Tr:CAB15914" /db_xref="GOA:P55181" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11898" /db_xref="UniProtKB/Swiss-Prot:P55181" /translation="MDLKWLQTFIAAAESESFREAAEHLYLTQPAVSQHMRKLEDELD MRLFLHSGRRVVLTDEGRLFLPYAKEMIHVYQAGKQKVSQWKQGYSRSLTLAVHPYIA SYILPRFLPAYIQKHPHVELSTHVAGSDAIKQAVEHNEADIGLSRKDPNTNTLYYQHI CEGTLCLAAPFQESRPDAASVLTRYRLLTHDHPSYGDAFLDNIRSHYPYLQMMAVGQT DTAVHMMKAGMGASFLPTYIIKQEEAEKKLMAVSTPAHLELPASQTFMMWKRNSEDIQ HFHAMLHDFMQREQV*" /label="yxjO CDS" gene 3462008..3462883 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /label="yxjO gene" S_feature complement(3462258..3462346) /Source="Nicolas_S_feature" /locus_tag="new_3991968_3992056_c" /HighExp="GM 60, MG-0.1, MG 10, GM 5, S8, T0.30H, BC, S6, GM 15, GM 150" /AntisenseName="yxjO" /AntisenseCor="0.14032494397598999" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0669" /TUlongSig="NA" /TUlongPSig="NA" /label="S1494" downshifts complement(3462280) /Source="Nicolas_upshifts" /id="D2018" /incds=1 /nref=22 /ntot=45 /MaxReadThrough="0.10815" /MaxDrop="6.05884" /score="5.06408541" /energy="-5.6" /TU="NA" /idTUdmin="U3069" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3462306..3462406) /Source="Nicolas_upshift_promotors" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3462346) /Source="Nicolas_upshifts" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="upshifts" CDS 3462961..3463434 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391768.1" /db_xref="EnsemblGenomes-Gn:BSU38890" /db_xref="EnsemblGenomes-Tr:CAB15915" /db_xref="GOA:P55182" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR020223" /db_xref="SubtiList:BG11897" /db_xref="UniProtKB/Swiss-Prot:P55182" /translation="MAMSPYIFIVLILIILSMYRERTVKPGKLLIIPLLLLWGVSASF QPAYFHSVLHVAISGILLLIGLACGFGIGKMVNVRIHPETGKVTSRGSLGSVILILVI LSLRMAARTWLPESNEMFIAIIHSMFFVPLGTITARNIMLYKAYRRLTAGKVSIQ*" /label="yxjN CDS" gene 3462961..3463434 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /label="yxjN gene" CDS 3463452..3464672 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxjL]" /protein_id="NP_391769.1" /db_xref="EnsemblGenomes-Gn:BSU38900" /db_xref="EnsemblGenomes-Tr:CAB15916" /db_xref="GOA:P55183" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11896" /db_xref="UniProtKB/Swiss-Prot:P55183" /translation="MNGQTPARHYYKKLVPSLILILNCIQFLSHPTKADPILLAFVFA VYLAFIWIIPYVASTAVSLSIFIGLWLLTDFFWAVSGQEQGAAYFLIVFLMIYAAFRL PSRLSLIFTACLIGGNILLLSSQGGSLNTIISNISIMLGLYVLFSSMRFRREARREAE RNHAELAKMHVQLEHAHKELQKAHAELQEASVLSLRYAVLEERTRIARDIHDSIGHEL TSVIVQLQSLPYILKSSKEDSEKVIQNVLSVARECLQEVRSVVHQMGRSESMVGLTAL RGLIHQVEERSGLHVSLDTAGLSEESWPPNVSETIYRILQEALTNIIRHADASHAAAV ISNDKSHLYVTITDDGQFTGSLTYGFGLTGMKERAEKAGGSLTFSAVQPSGLKIELSL PLMTTNKEQKDEQR*" /label="yxjM CDS" gene 3463452..3464672 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /label="yxjM gene" CDS 3464659..3465315 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YxjM]" /protein_id="NP_391770.1" /db_xref="EnsemblGenomes-Gn:BSU38910" /db_xref="EnsemblGenomes-Tr:CAB15917" /db_xref="GOA:P55184" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11895" /db_xref="UniProtKB/Swiss-Prot:P55184" /translation="MNKDKIRVALADDQPLVREGFRYVINAQTDMTVSGEAGDGHDII ALAKQTKPDVILMDVQMPRCSGIEAAKDIMSALPNTKIVILTTFDTEEYVFEGIRAGA VGYLLKDTLPEELIDAIRAAARGEAIFRTVTAAKIISETFRAKQQTHAEELAEPFTKR ELEVLQQMAYGLRNEDIAEKLFVSESTVKTHVHRILQKCNAQDRTQAVVFAIRNGIVQ *" /label="yxjL CDS" gene 3464659..3465315 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /label="yxjL gene" promotor_-35 3465313..3465318 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3465332..3465351 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3465335 /Source="Nicolas_upshifts" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="upshifts" CDS 3465365..3466597 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /EC_number="3.4.11.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8978088, 10987140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8978088, 10987140; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidase T (tripeptidase)" /protein_id="NP_391771.1" /db_xref="EnsemblGenomes-Gn:BSU38920" /db_xref="EnsemblGenomes-Tr:CAB15918" /db_xref="GOA:P55179" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010161" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11842" /db_xref="UniProtKB/Swiss-Prot:P55179" /translation="MKEEIIERFTTYVKVDTQSDESVDTCPSTPGQLTLGNMLVDELK SIGMQDAAIDENGYVMATLPSNTEKDVPTIGFLAHVDTATDFTGKNVNPQIIESYDGK DIVLNEQLQVTLSPDQFPELSGYKGHTLITTDGTTLLGADNKAGIAEIMTAMDYLIKH PEIKHGTIRVAFTPDEEIGRGPHKFDVKRFNASFAYTVDGGPLGELEYESFNAAAAKI TIKGNNVHPGTAKGKMINSAKIAMKLNSLLPADEAPEYTEGYEGFYHLLSIQGDVEET KLHYIIRDFDKENFQNRKETMKRAVEELQNEYGQDRILLDMNDQYYNMREKIEPVIEI VNIAKQAMENLGIEPKISPIRGGTDGSQLSYMGLPTPNIFTGGENFHGKFEYISVDNM VKAVNVIVEIAKQFEAQA*" /label="pepT CDS" gene 3465365..3466597 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /label="pepT gene" downshifts complement(3465382) /Source="Nicolas_upshifts" /id="D2019" /incds=0 /nref=4 /ntot=116 /MaxReadThrough="0.86167" /MaxDrop="3.19485" /score="-2.15704435" /energy="-9.1" /TU="NA" /idTUdmin="U3069" /TUdmin="-3102" /isTUend="FALSE" /label="downshifts" downshifts 3466582 /Source="Nicolas_upshifts" /id="D2020" /incds=0 /nref=203 /ntot=244 /MaxReadThrough="3.3949" /MaxDrop="6.35116" /score="27.2051031" /energy="-13.5" /TU="U3070" /idTUdmin="U3070" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 3466643..3466652 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3466665..3466680 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3466667..3466889 /Source="Nicolas_S_feature" /locus_tag="new_3996377_3996599" /HighExp="T-0.40H, T0.30H, T0.0H, T-1.40H, T1.0H, T-1.10H, T3.30H, T2.0H, T1.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.80396299999999998" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1495" upshifts 3466667 /Source="Nicolas_upshifts" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" downshifts 3466846 /Source="Nicolas_upshifts" /id="D2021" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="4.83682" /MaxDrop="4.66302" /score="-1.57383757" /energy="-6.2" /TU="U3071" /idTUdmin="U3070" /TUdmin=242 /isTUend="FALSE" /label="downshifts" promotor_-35 3466900..3466906 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-35" S_feature 3466919..3467019 /Source="Nicolas_S_feature" /locus_tag="new_3996629_3996729" /HighExp="Etha, Gly, Sw, Salt, B60, T0.30H, LoTm, M9-stat, T1.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1496" upshifts 3466919 /Source="Nicolas_upshifts" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="upshifts" promotor_-10 3466921..3466939 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-10" promotor_-35 3466998..3467005 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3467019..3467037 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3467021..3467118 /Source="Nicolas_S_feature" /locus_tag="new_3996731_3996828" /HighExp="Etha, T0.30H, Gly, T1.0H, Sw, Salt, T1.30H, GM 15, B60, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1497" upshifts 3467021 /Source="Nicolas_upshifts" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" CDS 3467119..3467382 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391772.1" /db_xref="EnsemblGenomes-Gn:BSU38930" /db_xref="EnsemblGenomes-Tr:CAB15919" /db_xref="GOA:P94353" /db_xref="SubtiList:BG12540" /db_xref="UniProtKB/Swiss-Prot:P94353" /translation="MLFIDLEFFEYFLAFYPYNREYQNFFWEVCNMILFIIIALCGYL LFSFSKDNRRKPQKTSPLPAAAPHHNNLIDLDAIRQKRRMHLS*" /label="yxjJ CDS" gene 3467119..3467382 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /label="yxjJ gene" promotor_-35 3467146..3467149 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3467164..3467183 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" upshifts 3467176 /Source="Nicolas_upshifts" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" downshifts 3467330 /Source="Nicolas_upshifts" /id="D2022" /incds=0 /nref=4 /ntot=92 /MaxReadThrough="7.33654" /MaxDrop="3.1638" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3467374 /Source="Nicolas_upshifts" /id="D2023" /incds=0 /nref=44 /ntot=188 /MaxReadThrough="5.58502" /MaxDrop="4.5161" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 3467449..3467458 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3467464 /Source="Nicolas_upshifts" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3467470..3467485 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3467511..3467999 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391773.1" /db_xref="EnsemblGenomes-Gn:BSU38940" /db_xref="EnsemblGenomes-Tr:CAB15920" /db_xref="InterPro:IPR007612" /db_xref="InterPro:IPR025659" /db_xref="SubtiList:BG12539" /db_xref="UniProtKB/Swiss-Prot:P94352" /translation="MIELFMKQKMFSFKDAFHIYDRDEQETFKVEGRFFSLGDSLQMT DSSGKTLVSIEQKLMSLLPRYEISIGGKTVCEVTKKVTFSKPKFVISGLNWEIDGDLW RDEFQLTDGENVRMSVSKKWLSWGDSYHLQIAYEEDVLICTAIAIVLDMVLYNDEDES IF*" /label="yxjI CDS" gene 3467511..3467999 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /label="yxjI gene" promotor_-35 3468004..3468011 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3468025..3468044 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3468035 /Source="Nicolas_upshifts" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3468065..3468171 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswI RNA" gene 3468065..3468171 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /label="mswI gene" downshifts 3468166 /Source="Nicolas_upshifts" /id="D2024" /incds=0 /nref=22 /ntot=102 /MaxReadThrough="7.18775" /MaxDrop="3.7896" /score="9.64734237" /energy="-14.5" /TU="U3075,U3076" /idTUdmin="U3072" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3468254..3469387 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyl-tetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391774.2" /db_xref="EnsemblGenomes-Gn:BSU38950" /db_xref="EnsemblGenomes-Tr:CAB15921" /db_xref="GOA:P42319" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11157" /db_xref="UniProtKB/Swiss-Prot:P42319" /translation="MAQQTNVAGQKTEKQRKAPFRADHVGSLLRSVPVKEARQKKAAG EMTAEQLRDIENQEITRIVEKQKEIGLDVVTDGEFRRSWWHYDFLEGLDGVEPFIPAE GIQFHNTKTKARSIKVTGKLDFTSHPALGDYQFLHEIAGNATPKLTIPSPNMLFFGEK ADKGIYDDQEEYFHDMAQAYKKAIKAFYDAGCRYLQLDDTSWSLFFEDKGREVVRALG GDPETLPAIFAKTINDAVADRPDDLTITMHICRGNFRSTWAASGGYDAVAETILDGLN LDGLFLEYDDDRSGNFDPLRFVKRKDLQIVLGLITSKYGELENPEDVKRRINEAARFV SLDQLCLSPQCGFASTEEGNLLTEEQQWAKLRHVIDIANDVWR*" /label="yxjH CDS" gene 3468254..3469387 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /label="yxjH gene" S_feature complement(3468527..3468770) /Source="Nicolas_S_feature" /locus_tag="new_3998237_3998480_c" /HighExp="dia15, Diami, H2O2, dia5, C90, Paraq, Sw, BC, LBGstat, Lbtran" /AntisenseName="yxjH" /AntisenseCor="-0.34694665046491102" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1498" promotor_-10 complement(3468765..3468784) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3468774) /Source="Nicolas_upshifts" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3468799..3468806) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3469393..3469400 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3469415..3469434 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3469421 /Source="Nicolas_upshifts" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3469456..3469562 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswJ RNA" gene 3469456..3469562 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /label="mswJ gene" downshifts 3469509 /Source="Nicolas_upshifts" /id="D2025" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="8.35488" /MaxDrop="3.50346" /score="29.0146782" /energy="-14.5" /TU="U3075,U3076,U3078" /idTUdmin="U3075" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature 3469563..3469639 /Source="Nicolas_S_feature" /locus_tag="new_3999273_3999349" /HighExp="MG 5, MG t5, T1.0H, MG 10, T1.30H, BMM, T0.30H, T-0.40H, T0.0H, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigD, SigB, SigWXY" /TUlongPSig="0.554, 1, 1, 1" /label="S1499" CDS 3469640..3470776 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254, 21749987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391775.3" /db_xref="EnsemblGenomes-Gn:BSU38960" /db_xref="EnsemblGenomes-Tr:CAB15922" /db_xref="GOA:P42318" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11156" /db_xref="UniProtKB/Swiss-Prot:P42318" /translation="MSQQTTPAEQKSLQRKKPPFRADQVGSLLRSEPVKKARLQKAAG EMTAEQLRQIENDEIIRIVEKQKETGLNVVTDGEFRRAWWHFDFLENLDGVEPFTPEQ GIQFHNVQTKARGIKVTGDIDFSTHPMLEDYSFLHSIAGDATPKMTIPSPNMLFFRGK LEKDEYKNDYQLFQHDVSKAYKKAIQAFYDRGCRYLQLDDTAWAVFLSEKGLKQIEAF GTTPDELRQLFAKSINDAIADRPDDLTVTMHICRGNFQSTWTAEGGYDAAAETIFDGL NLDGLFLEYDDSRSGGFEPLRYVKRSDLQLVLGLVTSKFGELENPDDVKRRIEEASRY VSLDQLCLSPQCGFASTEEGNKLTEEQQWAKLRHVVEIANDVWK*" /label="yxjG CDS" gene 3469640..3470776 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /label="yxjG gene" downshifts 3470763 /Source="Nicolas_upshifts" /id="D2026" /incds=0 /nref=81 /ntot=187 /MaxReadThrough="4.24668" /MaxDrop="5.8124" /score="11.1243305" /energy="-12.8" /TU="U3076,U3078" /idTUdmin="U3075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3470829..3471602) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacid dehydrogenase" /protein_id="NP_391776.2" /db_xref="EnsemblGenomes-Gn:BSU38970" /db_xref="EnsemblGenomes-Tr:CAB15923" /db_xref="GOA:P42317" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011294" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11155" /db_xref="UniProtKB/Swiss-Prot:P42317" /translation="MRKQVALVTGAAGGIGFEIAREFAREGASVIVSDLRPEACEKAA SKLAEEGFDAAAIPYDVTKEAQVADTVNVIQKQYGRLDILVNNAGIQHVAPIEEFPTD TFEQLIKVMLTAPFIAMKHVFPIMKKQQFGRIINIASVNGLVGFAGKSAYNSAKHGVI GLTKVGALEGAPHGITVNALCPGYVDTQLVRNQLSDLSKTRNVPYDSVLEQVIFPLVP QKRLLSVKEIADYAVFLASEKAKGVTGQAVVLDGGYTAQ*" /label="yxjF CDS" gene complement(3470829..3471602) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /label="yxjF gene" downshifts complement(3470839) /Source="Nicolas_upshifts" /id="D2027" /incds=0 /nref=23 /ntot=63 /MaxReadThrough="0.65" /MaxDrop="6.97604" /score="24.6585594" /energy="-12.8" /TU="NA" /idTUdmin="U3079" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3471619..3472269) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit B)" /protein_id="NP_391777.1" /db_xref="EnsemblGenomes-Gn:BSU38980" /db_xref="EnsemblGenomes-Tr:CAB15924" /db_xref="GOA:P42316" /db_xref="InterPro:IPR004164" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11154" /db_xref="UniProtKB/Swiss-Prot:P42316" /translation="MKEARKRMVKRAVQEIKDGMNVNLGIGMPTLVANEIPDGVHVML QSENGLLGIGPYPLEGTEDADLINAGKETITEVTGASYFDSAESFAMIRGGHIDLAIL GGMEVSEQGDLANWMIPGKMVKGMGGAMDLVNGAKRIVVIMEHVNKHGESKVKKTCSL PLTGQKVVHRLITDLAVFDFVNGRMTLTELQDGVTIEEVYEKTEADFAVSQSVLNS*" /label="scoB CDS" gene complement(3471619..3472269) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /label="scoB gene" CDS complement(3472266..3472982) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit A)" /protein_id="NP_391778.1" /db_xref="EnsemblGenomes-Gn:BSU38990" /db_xref="EnsemblGenomes-Tr:CAB15925" /db_xref="GOA:P42315" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11153" /db_xref="UniProtKB/Swiss-Prot:P42315" /translation="MGKVLSSSKEAAKLIHDGDTLIAGGFGLCGIPEQLILSIRDQGV KDLTVVSNNCGVDDWGLGLLLANKQIKKMIASYVGENKIFERQFLSGELEVELVPQGT LAERIRAGGAGIPGFYTATGVGTSIAEGKEHKTFGGRTYVLERGITGDVAIVKAWKAD TMGNLIFRKTARNFNPIAAMAGKITIAEAEEIVEAGELDPDHIHTPGIYVQHVVLGAS QEKRIEKRTVQQASGKGEAK*" /label="scoA CDS" gene complement(3472266..3472982) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /label="scoA gene" CDS complement(3473006..3474424) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative acid metabolite permease" /protein_id="NP_391779.3" /db_xref="EnsemblGenomes-Gn:BSU39000" /db_xref="EnsemblGenomes-Tr:CAB15926" /db_xref="GOA:P42314" /db_xref="SubtiList:BG11152" /db_xref="UniProtKB/Swiss-Prot:P42314" /translation="MELIIILLALGLLMFTAYRGFSVILFAPICALFAVLLTDPSHVL PFFSSIFMEKMAGFIKLYFPVFLLGAIFGKVVEMAGLAASIAKTIVRLVGAKRAILAI VLMGAVLTYSGVSLFVVVFAVYPFAKNMFQEANIPKRLIPGTIALGAFTFTMDALPGT PQIQNVIPTSFFKTDIYAAPWLGLMGAVIVLAAGMLYLESRRKKAQASGEGYGGFDSQ NAPAPESIESAAEPDKSPIRHALAFVPLILVGAVNKYFTIYLPKWYPNGFDFSSIGLK EFGRLDISSAAAIWSVEIALVIGIITTILFDWRSVFAQLKEGLNEGIGGALLASMNTG AEYGFGGIIAALPGFHKLSSGISHTFTDPLVNGAVTTTALAGITGSASGGMGIALSAM SEQYLQAIQAYNIPPEVMHRVISMASGGMDTLPHNGAVITLLAVTGLTHRQSYRDIFA ITLIKTAAVFAVIAIYSLTGLV*" /label="yxjC CDS" gene complement(3473006..3474424) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /label="yxjC gene" promotor_-10 complement(3473592..3473610) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3473611) /Source="Nicolas_upshifts" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3473626..3473631) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3474425..3474509) /Source="Nicolas_S_feature" /locus_tag="new_4004135_4004219_c" /HighExp="S5, S4, S6, S3, S7, M9-stat, B60, S8, T4.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1500" promotor_-10 complement(3474493..3474511) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3474509) /Source="Nicolas_upshifts" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3474527..3474532) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3474578..3475426) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /EC_number="2.1.1.188" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11967079, 14999102, 18406425, 23716046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m(1)G748 methyltransferase (class II)" /protein_id="NP_391780.1" /db_xref="EnsemblGenomes-Gn:BSU39010" /db_xref="EnsemblGenomes-Tr:CAB15927" /db_xref="GOA:P42313" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR016718" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11151" /db_xref="UniProtKB/Swiss-Prot:P42313" /translation="MKRTVDFSMFRCPLCDSSMDAASGKSLICTERGHTFDLSRHGYV NFLTKPVKTSYGAELFEARSRLIGECGFFDPLHDAIAELISHPKSGHEAFTILDSGCG EGSHLNALCGFDYAGKAAIGTGIDLSKDGILKASKAFKDLMWAVADVARAPFHDRQFD VVLSIFSPSNYAEFHRLLKNDGMLIKVVPRSDYLIELRQFLYTDSPRRTYSNTAAVER FTANAAHSRPVRLRYVKTLDQQAIHWLLKMTPLAWSAPKDRVSLLKEMKSADITVDVD ILIGMK*" /label="rlmA CDS" gene complement(3474578..3475426) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /label="rlmA gene" downshifts complement(3474588) /Source="Nicolas_upshifts" /id="D2028" /incds=0 /nref=54 /ntot=218 /MaxReadThrough="1.618" /MaxDrop="4.63737" /score="17.0758624" /energy="-15.1" /TU="NA" /idTUdmin="U3081" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(3475427..3475612) /Source="Nicolas_S_feature" /locus_tag="new_4005137_4005322_c" /HighExp="B60, LBGstat, LPhT, M9-stat, C30, T0.30H, HPh, Oxctl, Heat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1501" promotor_-10 complement(3475601..3475620) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3475612) /Source="Nicolas_upshifts" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3475614..3476339) /Source="Nicolas_S_feature" /locus_tag="new_4005324_4006049_c" /HighExp="LBGstat, C30, GM 25, Heat, GM 10, GM 45, GM 60, GM 90, T0.30H, GM 120" /AntisenseName="NA" /AntisenseCor="0.20859849915331599" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1502" promotor_-35 complement(3475636..3475640) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3475774..3475781 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3475794..3475813 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3475803 /Source="Nicolas_upshifts" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3475813..3475915 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" /label="gswB RNA" gene 3475813..3475915 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /label="gswB gene" S_feature 3475916..3476019 /Source="Nicolas_S_feature" /locus_tag="new_4005626_4005729" /HighExp="C90, G180, M40t45, dia15, LBGexp, Lbexp, Lbtran, G135, Mt0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1503" promotor_-35 3475991..3475997 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3476011..3476022 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3476021 /Source="Nicolas_upshifts" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="upshifts" CDS 3476042..3477235 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12787499, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="purine nucleoside transporter" /protein_id="NP_391781.2" /db_xref="EnsemblGenomes-Gn:BSU39020" /db_xref="EnsemblGenomes-Tr:CAB15928" /db_xref="GOA:P42312" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG11150" /db_xref="UniProtKB/Swiss-Prot:P42312" /translation="MYFLLNLVGLIVIMAVVFLCSPQKKKIKWRPIITLIVLELLITW FMLGTKVGSWAIGKIGDFFTWLIACASDGIAFAFPSVMANETVDFFFSALLPIIFIVT FFDILTYFGILPWLIDKIGWVISKASRLPKLESFFSIQMMFLGNTEALAVIRQQLTVL SNNRLLTFGLMSMSSISGSIIGSYLSMVPATYVFTAIPLNCLNALIIANLLNPVHVPE DEDIIYTPPKEEKKDFFSTISNSMLVGMNMVIVILAMVIGYVALTSAVNGILGVFVHG LTIQTIFAYLFSPFAFLLGLPVHDAMYVAQLMGMKLATNEFVAMLDLKNNLKSLPPHT VAVATTFLTSFANFSTVGMIYGTYNSILDGEKSTVIGRNVWKLLVSGIAVSLLSAAIV GLFVW*" /label="nupG CDS" gene 3476042..3477235 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /label="nupG gene" promotor_-10 complement(3476326..3476344) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3476342) /Source="Nicolas_upshifts" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3476357..3476364) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3477011 /Source="Nicolas_upshifts" /id="D2029" /incds=1 /nref=1 /ntot=58 /MaxReadThrough="5.88279" /MaxDrop="2.4159" /score="8.04757856" /energy="-16.6" /TU="U3082,U3083" /idTUdmin="U3082" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" downshifts 3477231 /Source="Nicolas_upshifts" /id="D2030" /incds=0 /nref=71 /ntot=204 /MaxReadThrough="2.7474" /MaxDrop="4.05925" /score="8.04757856" /energy="-16.6" /TU="NA" /idTUdmin="U3082" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3477277..3477705) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminus)" /translation="KTKKQANSRALKREYQTSFSVKYNAAGKLSIQTLNYIYSGGAHG LTSVQSFNYDLKAQKRVTLDQILNTKTKVSKTRDYLYSYIKKHDVLFFSDVKKEDITL NRDTMFYFTANGIAIVFGQYDLGPYAAGIRDVQVPASIYQ*" /label="yxiTc CDS" gene complement(3477277..3477705) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /pseudo /label="yxiTc gene" CDS complement(3477706..3477948) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (N-terminus)" /db_xref="PSEUDO:CAB15929.2" /db_xref="SubtiList:BG11149" /db_xref="UniProtKB/Swiss-Prot:P42311" /translation="MKWNNMLKAAGIAVLLFSVFAYAAPSLKAVQAKTPTVSTHTYKK IKELTYPQVHHVGNAAFEKKINQELKAYMNNRIRNT*" /label="yxiTn CDS" gene complement(3477706..3477948) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /pseudo /label="yxiTn gene" S_feature complement(3477949..3478012) /Source="Nicolas_S_feature" /locus_tag="new_4007659_4007722_c" /HighExp="T2.30H, S6, Etha, T3.30H, S5, BT, T3.0H, T4.0H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.942" /TUlongSig="NA" /TUlongPSig="NA" /label="S1504" promotor_-10 complement(3478001..3478016) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3478012) /Source="Nicolas_upshifts" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3478028..3478037) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3478045 /Source="Nicolas_upshifts" /id="D2031" /incds=0 /nref=10 /ntot=69 /MaxReadThrough="0.814549999999999" /MaxDrop="3.89525" /score="14.5338714" /energy="-6.9" /TU="NA" /idTUdmin="U3082" /TUdmin=814 /isTUend="FALSE" /label="downshifts" CDS complement(3478093..3478383) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391783.2" /db_xref="EnsemblGenomes-Gn:BSU39040" /db_xref="EnsemblGenomes-Tr:CAB15930" /db_xref="SubtiList:BG11148" /db_xref="UniProtKB/Swiss-Prot:P42310" /translation="MNEKQLTEAYERDENMMILVFAQWCVNHDLDPMELYAKAYPQQK LNESLKKTMDDLVVPKHEAEHIPDQTVIAVLEMFGNTDLAQALHEAISGRKQ*" /label="yxiS CDS" gene complement(3478093..3478383) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /label="yxiS gene" downshifts complement(3478099) /Source="Nicolas_upshifts" /id="D2032" /incds=0 /nref=168 /ntot=241 /MaxReadThrough="3.10756" /MaxDrop="6.10709" /score="16.5130207" /energy="-6.9" /TU="NA" /idTUdmin="U3086" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3478408..3478427) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3478425) /Source="Nicolas_upshifts" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3478433..3480493) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7559348, 8931328, 16151211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559348, 8931328, 16151211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catalase 2" /protein_id="NP_391784.2" /db_xref="EnsemblGenomes-Gn:BSU39050" /db_xref="EnsemblGenomes-Tr:CAB15931" /db_xref="GOA:P42234" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024712" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11102" /db_xref="UniProtKB/Swiss-Prot:P42234" /translation="MSDDQNKRVNEHSKDEQLEQYRTDNSGKKMTTNQGLRVSEDEHS LKAGVRGPTLMEDFHFREKMTHFDHERIPERVVHARGFGVHGFFQVYEPMTEYTRAKF LQDPSVKTPVFVRFSTVAGSKGSADTVRDARGFATKFYTEEGNYDLVGNNIPVFFIQD AIKFPDLVHAFKPEPHNEMPQAATAHDTFWDFVANNPESAHMVMWTMSDRGIPRSYRM MEGFGVHTFRFVNEQGKARFVKFHWKPVLGVHSLVWDEAQKIAGKDPDFHRRDLWETI ENGGKVEYELGVQMIDEEDEFKFDFDILDPTKLWPEELVPVKIIGKMTLNRNQDNVFA ETEQVAFHPGNVVPGIDFTNDPLLQGRLFSYTDTQLIRLGGPNFHEIPINRPVCPFHN NQYDGYHRMTINKGPVAYHKNSLQNNDPSPATAEEGGYVHYQEKVEGKKIRQRSDSFN DYYSQAKLFWNSMSPVEKQHIISAFCFEVGKVKSKDVQRQVVDVFSNVDADLAEEIAK GVGVAAPAKRKASKEILTSPALSQARTVKTASTRKVAVLAGNGFHEKELQTVLEALKQ EGITVDIISQNLGYMTSGSGQQLEASGTFLTVDSVLYDAVYAAGGLELKDNKQAMAFI REAYNHYKAIGAANEGIDLLQSSVGTTEGLGIVTAKDEPDYTAFSKAFIDAVAAHRHW DRRI*" /label="katE CDS" gene complement(3478433..3480493) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /label="katE gene" promotor_-35 complement(3478441..3478448) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3480522..3480540) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3480526) /Source="Nicolas_upshifts" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3480555..3480561) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3480586..3480591 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3480605 /Source="Nicolas_upshifts" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3480607..3480625 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3480619..3480693 /Source="Nicolas_S_feature" /locus_tag="new_4010329_4010403" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, LoTm, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1505" CDS 3480694..3481974 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8892821, 11053381, 15849754, 16850406, 18556792" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8892821, 11053381, 15849754, 16850406, 18556792; Product type t : transporter" /codon_start=1 /transl_table=11 /product="secondary transporter of divalent metal ions/citrate complexes" /protein_id="NP_391785.2" /db_xref="EnsemblGenomes-Gn:BSU39060" /db_xref="EnsemblGenomes-Tr:CAB15932" /db_xref="GOA:P42308" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11146" /db_xref="UniProtKB/Swiss-Prot:P42308" /translation="MLAILGFVMMIVFMYLIMSNRLSALIALIVVPIVFALISGFGKD LGEMMIQGVTDLAPTGIMLLFAILYFGIMIDSGLFDPLIAKILSFVKGDPLKIAVGTA VLTMTISLDGDGTTTYMITIAAMLPLYKRLGMNRLVLAGIAMLGSGVMNIIPWGGPTA RVLASLKLDTSEVFTPLIPAMIAGILWVIAVAYILGKKERKRLGVISIDHAPSSDPEA APLKRPALQWFNLLLTVALMAALITSLLPLPVLFMTAFAVALMVNYPNVKEQQKRISA HAGNALNVVSMVFAAGIFTGILSGTKMVDAMAHSLVSLIPDAMGPHLPLITAIVSMPF TFFMSNDAFYFGVLPIIAEAASAYGIDAAEIGRASLLGQPVHLLSPLVPSTYLLVGMA GVSFGDHQKFTIKWAVGTTIVMTIAALLIGIISF*" /label="citH CDS" gene 3480694..3481974 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /label="citH gene" S_feature 3481975..3482114 /Source="Nicolas_S_feature" /locus_tag="new_4011685_4011824" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, BT, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.382965" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1506" downshifts 3482071 /Source="Nicolas_upshifts" /id="D2033" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.69139" /MaxDrop="3.50434" /score="10.8797157" /energy="-9" /TU="NA" /idTUdmin="U3088" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3482132..3482860) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /EC_number="3.2.1.73" /EC_number="3.2.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1369198, 3106158, 7704256, 20600285, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1369198, 3106158, 7704256, 20600285, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,3-1,4 glucanase" /protein_id="NP_391786.1" /db_xref="EnsemblGenomes-Gn:BSU39070" /db_xref="EnsemblGenomes-Tr:CAB15943" /db_xref="GOA:P04957" /db_xref="InterPro:IPR000757" /db_xref="InterPro:IPR008263" /db_xref="InterPro:IPR008264" /db_xref="InterPro:IPR013320" /db_xref="PDB:3O5S" /db_xref="SubtiList:BG10476" /db_xref="UniProtKB/Swiss-Prot:P04957" /translation="MPYLKRVLLLLVTGLFMSLFAVTATASAQTGGSFFDPFNGYNSG FWQKADGYSNGNMFNCTWRANNVSMTSLGEMRLALTSPAYNKFDCGENRSVQTYGYGL YEVRMKPAKNTGIVSSFFTYTGPTDGTPWDEIDIEFLGKDTTKVQFNYYTNGAGNHEK IVDLGFDAANAYHTYAFDWQPNSIKWYVDGQLKHTATNQIPTTPGKIMMNLWNGTGVD EWLGSYNGVNPLYAHYDWVRYTKK*" /label="bglS CDS" gene complement(3482132..3482860) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /label="bglS gene" downshifts complement(3482149) /Source="Nicolas_upshifts" /id="D2034" /incds=0 /nref=64 /ntot=139 /MaxReadThrough="1.52649" /MaxDrop="6.38109" /score="-8.35070051" /energy="-16.3" /TU="NA" /idTUdmin="U3089" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3482891..3482910) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3482902) /Source="Nicolas_upshifts" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3482924..3482931) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3483048..3483155) /Source="Nicolas_S_feature" /locus_tag="new_4012758_4012865_c" /HighExp="Sw, LPhT, T0.30H, M0t90, M9-stat, M40t90, Lbtran, Lbstat, S2, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1507" downshifts complement(3483091) /Source="Nicolas_upshifts" /id="D2035" /incds=0 /nref=21 /ntot=184 /MaxReadThrough="3.35114" /MaxDrop="4.38508" /score="-8.35070051" /energy="-16.3" /TU="U3090,U3091" /idTUdmin="U3091" /TUdmin="-174" /isTUend="FALSE" /label="downshifts" CDS complement(3483156..3483989) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_391787.2" /db_xref="EnsemblGenomes-Gn:BSU39080" /db_xref="EnsemblGenomes-Tr:CAB15944" /db_xref="GOA:P39805" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1H99" /db_xref="PDB:1L1C" /db_xref="PDB:1TLV" /db_xref="SubtiList:BG10474" /db_xref="UniProtKB/Swiss-Prot:P39805" /translation="MKIAKVINNNVISVVNEQGKELVVMGRGLAFQKKSGDDVDEARI EKVFTLDNKDVSEKFKTLLYDIPIECMEVSEEIISYAKLQLGKKLNDSIYVSLTDHIN FAIQRNQKGLDIKNALLWETKRLYKDEFAIGKEALVMVKNKTGVSLPEDEAGFIALHI VNAELNEEMPNIINITKVMQEILSIVKYHFKIEFNEESLHYYRFVTHLKFFAQRLFNG THMESQDDFLLDTVKEKYHRAYECTKKIQTYIEREYEHKLTSDELLYLTIHIERVVKQ A*" /label="licT CDS" gene complement(3483156..3483989) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /label="licT gene" promotor_-10 complement(3484020..3484039) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3484039) /Source="Nicolas_upshifts" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3484053..3484060) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3484085..3484765) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391788.1" /db_xref="EnsemblGenomes-Gn:BSU39090" /db_xref="EnsemblGenomes-Tr:CAB15945" /db_xref="SubtiList:BG11145" /db_xref="UniProtKB/Swiss-Prot:P42307" /translation="MRRIGLCISLLVTVLVMSACESEGEAQMFADCDQKTVKQTAAKP MSSKKKQDFQALASDRQLAIVFSSMIQVSEAFDYGIGNPEYFVRISMTEEEADIAKEN LESIKLENKSLKKQNSEAVALLQKTRNQDMSRIEIQQLTENRAGFFETADSMIKLINQ VTPKNAKKTRQQLDQLKKQYTQYSAESIKIMNSIVKKQKADKASFERHLEALLQKQPG QQVRSELY*" /label="yxiP CDS" gene complement(3484085..3484765) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /label="yxiP gene" promotor_-10 complement(3484812..3484831) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-10" upshifts complement(3484821) /Source="Nicolas_upshifts" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="upshifts" promotor_-35 complement(3484845..3484852) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-35" promotor_-35 3484913..3484916 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3484931..3484950 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3484931 /Source="Nicolas_upshifts" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="upshifts" CDS 3484972..3486258 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12583894, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391789.1" /db_xref="EnsemblGenomes-Gn:BSU39100" /db_xref="EnsemblGenomes-Tr:CAB15946" /db_xref="GOA:P42306" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024671" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11144" /db_xref="UniProtKB/Swiss-Prot:P42306" /translation="MMKRFTKQENSWVLYDWANSAYSIVVTTAVFPLFYKSAAAESGV SAAQSTAYLGYTIAISTFILAMLGPILGTIADYEGCKKKFFGFFVSAGVASTAMLAFI PSEHWLLLLLFYTVSAIGFSGANVFYDAFLVDVTPEKRMNLVSARGFGLGYIGSTIPF IISIAVILLAQAETIPVSVSAASQLSFFITAAWWGLFTIPMIKHVHQRYYIKKEPHIV INSFKRLGQTMKRIRQYRALFLFLLAYFFYIDGVGTIITMSTSYGSDLGIGSSSLLII LFVTQVVAAPFSIIYGKLAERFTGKTMLYVGIVIYMIVCVYAYFMETTLDFWILAMLV ATSQGGIQALSRSYFAKLVPKRHANEFFGFYNIFGKFASIMGPLLIAVTAQLTGKSST AVFSLIILFVIGIVILAFVPEETSTDVSQQQNDLPL*" /label="yxiO CDS" gene 3484972..3486258 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /label="yxiO gene" promotor_-10 complement(3485703..3485721) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3485711) /Source="Nicolas_upshifts" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3485735..3485742) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3486229 /Source="Nicolas_upshifts" /id="D2036" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="2.50578" /MaxDrop="3.06646" /score="-7.45683354" /energy="-16.7" /TU="NA" /idTUdmin="U3092" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3486277..3487716) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase for 23S ribosomal RNAmaturation" /protein_id="NP_391790.2" /db_xref="EnsemblGenomes-Gn:BSU39110" /db_xref="EnsemblGenomes-Tr:CAB15947" /db_xref="GOA:P42305" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005580" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028619" /db_xref="PDB:2G0C" /db_xref="PDB:2HJV" /db_xref="PDB:3MOJ" /db_xref="SubtiList:BG11143" /db_xref="UniProtKB/Swiss-Prot:P42305" /translation="MSHFKNYQISHDILRALEGLGYTEPTKVQQSVIPAALERKDLVV KSQTGSGKTASFGIPLCELANWDENKPQALILTPTRELAVQVKEDITNIGRFKRIKAT AVFGKSSFDKQKAELKQKSHIVVGTPGRVLDHIEKGTLPLDRLSYLVIDEADEMLNMG FIEQVEAIIKHLPTERTTMLFSATLPQDIEKLSRQYMQNPEHIEVKAAGLTTRNIEHA VIQVREENKFSLLKDVLMTENPDSCIIFCRTKEHVNQLTDELDDLGYPCDKIHGGMIQ EDRFDVMNEFKRGEYRYLVATDVAARGIDIENISLVINYDLPLEKESYVHRTGRTGRA GNKGKAISFVTAFEKRFLADIEEYIGFEIQKIEAPSQEEVARKKPEFLAKLNDRPESK KDKSEELNKDIMKLYFNGGKKKKIRAVDFVGTIAKIDGVSADDIGIITIMDNASYVEI LNGKGPHVLKVMKNTTVKGKQLKVNKANK*" /label="deaD CDS" gene complement(3486277..3487716) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /label="deaD gene" downshifts complement(3486300) /Source="Nicolas_upshifts" /id="D2037" /incds=0 /nref=200 /ntot=269 /MaxReadThrough="1.50578" /MaxDrop="5.83238" /score="3.28924902" /energy="-18.2" /TU="NA" /idTUdmin="U3095" /TUdmin=5 /isTUend="TRUE" /label="downshifts" misc_feature complement(3487740..3487759) /Source="Nicolas_upshift_promotors" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3487757) /Source="Nicolas_upshifts" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3487798..3488946) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10746760, 25394512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="esterase (lipoprotein)" /protein_id="NP_391791.2" /db_xref="EnsemblGenomes-Gn:BSU39120" /db_xref="EnsemblGenomes-Tr:CAB15948" /db_xref="GOA:P42304" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="PDB:2O14" /db_xref="SubtiList:BG11142" /db_xref="UniProtKB/Swiss-Prot:P42304" /translation="MKKWMAAVFVMMLMLCFGGIENVKAAEPKVYQFDFGSGSMEPGY IGVRASDRYDRSKGYGFQTPENMRDVAASGAGVKSDAVQFLAYGTKSNNTFNVDLPNG LYEVKVTLGNTARASVAAEGVFQVINMTGDGAEDTFQIPVTDGQLNLLVTEGKAGTAF TLSALKIKKLSDQPVTNRTIYVGGDSTVCNYYPLNSSKQAGWGQMLPHYIDKHTFQVR NMASGGQIARGFRNDGQLEAILKYIKPGDYFMLQLGINDTNPKHKESEAEFKEVMRDM IRQVKAKGADVILSTPQGRATDFTSEGIHSSVNRWYRASILALAEEEKTYLIDLNVLS SAYFTSIGPERTLGLYMDGDTLHPNRAGADALARLAVQELKRQGIAGF*" /label="yxiM CDS" gene complement(3487798..3488946) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /label="yxiM gene" promotor_-10 complement(3488973..3488989) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3488989) /Source="Nicolas_upshifts" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3488991..3489075) /Source="Nicolas_S_feature" /locus_tag="new_4018701_4018785_c" /HighExp="T3.30H, T4.0H, T2.30H, T3.0H, T2.0H, T-3.40H, T5.0H, T-2.40H, Lbexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1508" promotor_-35 complement(3489004..3489009) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3489076..3489264) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52710.1" /translation="MRFENISASKLDDLESIDSVALEIVPTDDQWERLRYYVYDEENQ ISFYCGGWDVIKCDKKSH*" /label="yxzI CDS" gene complement(3489076..3489264) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /pseudo /label="yxzI gene" CDS complement(3489295..3489426) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097796.1" /db_xref="EnsemblGenomes-Gn:BSU39139" /db_xref="EnsemblGenomes-Tr:CAX52711" /db_xref="UniProtKB/Swiss-Prot:C0H3T5" /translation="MNITQYEKLKQHLSDEDTGPFTLNEFSFYMKEDDRYIHIPVFE* " /label="yxzJ CDS" gene complement(3489295..3489426) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /label="yxzJ gene" CDS complement(3489438..3489899) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type f: factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391793.1" /db_xref="EnsemblGenomes-Gn:BSU39140" /db_xref="EnsemblGenomes-Tr:CAB15950" /db_xref="SubtiList:BG11140" /db_xref="UniProtKB/Swiss-Prot:P42302" /translation="MEITSISSIGNLDMIELKPDQTVMACELEDAESFYRFWAGLAYD RIMIQVITTGSFIEDLSEYFEGHAYKVTKLAKREFHFQSILQEADRDIADFLFLLASI NDDVFLITDPQPDKSYFSEGKLQCLTDSGERIIWFEYDAVDIYMIGGESYK*" /label="yxiK CDS" gene complement(3489438..3489899) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /label="yxiK gene" CDS complement(3489915..3490211) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391794.1" /db_xref="EnsemblGenomes-Gn:BSU39150" /db_xref="EnsemblGenomes-Tr:CAB15951" /db_xref="InterPro:IPR025551" /db_xref="SubtiList:BG11139" /db_xref="UniProtKB/Swiss-Prot:P42320" /translation="MLQKLRKRQRELEEKQYPDELYGFEAEIYEFFMLVAGSLDYVLA NKRIPRHQRRSLEKSFFELYPDILPDMIKNDKDLYHHILLYEQVRQEICVALSN*" /label="yxiJ CDS" gene complement(3489915..3490211) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /label="yxiJ gene" CDS complement(3490239..3490727) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391795.1" /db_xref="EnsemblGenomes-Gn:BSU39160" /db_xref="EnsemblGenomes-Tr:CAB15952" /db_xref="InterPro:IPR020323" /db_xref="SubtiList:BG11138" /db_xref="UniProtKB/Swiss-Prot:P42301" /translation="MMNWRALSQTKQDRIWSEVNKIIKWKPGSRCHHIIPPDPYRVFD ISSAMSSKAGHNDVSGVLSDLETSILKAFQLGTGKNDVMYALDWQHDGYTFSPHQAMP KDEFGEWPVPVFPNGDYYFFFHQDFSWGLLGDPWKCAITVFGEELLEAIDNDPPILFR NK*" /label="yxiI CDS" gene complement(3490239..3490727) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /label="yxiI gene" CDS complement(3490745..3491197) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391796.1" /db_xref="EnsemblGenomes-Gn:BSU39170" /db_xref="EnsemblGenomes-Tr:CAB15953" /db_xref="SubtiList:BG14170" /db_xref="UniProtKB/Swiss-Prot:O32285" /translation="MWCFTLDGQQKEIHIDRKLEEMDAPAVDDCYGLAEKNGLIYMLY YGDAVIAAFDETVVRRVWILSDKEPDSEAFDQLAISEEGFLVGTFNCYSADLKSSLYL ISADVSQEMEEITCCDSNGEGLDVQQLKLTSYAVYAVASSGVYKQDIQ*" /label="yxzG CDS" gene complement(3490745..3491197) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /label="yxzG gene" S_feature complement(3491198..3491266) /Source="Nicolas_S_feature" /locus_tag="new_4020908_4020976_c" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, T2.0H, T-3.40H, T5.0H, T-2.40H, T-4.40H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19384199999999999" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1509" CDS complement(3491267..3491596) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391797.1" /db_xref="EnsemblGenomes-Gn:BSU39180" /db_xref="EnsemblGenomes-Tr:CAB15954" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11137" /db_xref="UniProtKB/Swiss-Prot:P42300" /translation="MKKLKLNKIINENTQDCFFHADPQGRVYIGKGLKGGITITIYDP SGDVRDFRVKEQISYSDILLFQQCADGYVFVYYESYEPKVKVFSEEGRVKSVFHLPSG VSCCLLD*" /label="yxiH CDS" gene complement(3491267..3491596) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /label="yxiH gene" S_feature complement(3491597..3491718) /Source="Nicolas_S_feature" /locus_tag="new_4021307_4021428_c" /HighExp="T3.30H, T4.0H, T3.0H, T2.30H, T-4.40H, T-3.40H, LBGexp, T-2.40H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1510" CDS complement(3491719..3492135) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391798.1" /db_xref="EnsemblGenomes-Gn:BSU39190" /db_xref="EnsemblGenomes-Tr:CAB15955" /db_xref="SubtiList:BG11136" /db_xref="UniProtKB/Swiss-Prot:P42299" /translation="MTMYQTINEWVDYIDKGCSVLHLDFNVFKKELSLDIKVFEDEGE YTHKISFQNVASAYYSADVGDMRLEKIDPEEYNWQVFEMSYHPEGIGNLSNSIIPEYQ SNANFLIDMNRMLIAIEAETVRFDDQSFYAYQLNTK*" /label="yxiG CDS" gene complement(3491719..3492135) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /label="yxiG gene" CDS complement(3492186..3492554) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391799.1" /db_xref="EnsemblGenomes-Gn:BSU39200" /db_xref="EnsemblGenomes-Tr:CAB15956" /db_xref="SubtiList:BG14167" /db_xref="UniProtKB/Swiss-Prot:O32286" /translation="MVDWKPFGTYLLRKKLQYLNISTVLCILIKNHLVLEYVVIKLSE TNLIECINKIKSVLNGQTTREEVSDWAGTYVYADDPEVEDDRVWDMLILLSGIDLKDS SETYLHSTDDLNDWIKQYTE*" /label="yxzC CDS" gene complement(3492186..3492554) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /label="yxzC gene" CDS complement(3492548..3493018) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391800.1" /db_xref="EnsemblGenomes-Gn:BSU39210" /db_xref="EnsemblGenomes-Tr:CAB15957" /db_xref="SubtiList:BG11135" /db_xref="UniProtKB/Swiss-Prot:P42298" /translation="MQKRLIEKLAENKRRLLMSEIKEKLVPCAERGFTYRFADLAQSR QLLELVLSNSIPANTREVDALEKTEAKQLIWKISQSYVAYDDRDVLLFHQYSSEIGAL VCSFGKCLEHLDCLLECIEFDEGILNHSFILVEPKCQFGLCILHTEYGCELVYW*" /label="yxiF CDS" gene complement(3492548..3493018) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /label="yxiF gene" S_feature complement(3493019..3493343) /Source="Nicolas_S_feature" /locus_tag="new_4022729_4023053_c" /HighExp="T3.30H, T-2.40H, T2.30H, T3.0H, T4.0H, SMMPr, MG 120, C90, T2.0H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1511" CDS complement(3493344..3493772) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /experiment="publication(s) with functional evidences, PMID:1529529, 16306698, 19763274, 23572593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1529529, 16306698, 19763274, 23572593; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin of WapA tRNase" /protein_id="NP_391801.1" /db_xref="EnsemblGenomes-Gn:BSU39220" /db_xref="EnsemblGenomes-Tr:CAB15958" /db_xref="SubtiList:BG10798" /db_xref="UniProtKB/Swiss-Prot:Q07836" /translation="MAKIKDDCIELELTPRRYQELDDDPFILSVFELLENKKAVVRDF SAVLLESEYKVLISGIETMIKGNQDSISLETIEPFLFLSIDQENGNYRIKIKIIFDDY KESKSNSNLFEINCNEEKLESFVTALKLNLENTKNPSKLP*" /label="wapI CDS" gene complement(3493344..3493772) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /label="wapI gene" CDS complement(3493834..3500838) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall-associated tRNA nuclease precursor; intercellular growth inhibitor" /protein_id="NP_391802.2" /db_xref="EnsemblGenomes-Gn:BSU39230" /db_xref="EnsemblGenomes-Tr:CAB15959" /db_xref="GOA:Q07833" /db_xref="InterPro:IPR006530" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR022385" /db_xref="InterPro:IPR031325" /db_xref="SubtiList:BG10797" /db_xref="UniProtKB/Swiss-Prot:Q07833" /translation="MKKRKRRNFKRFIAAFLVLALMISLVPADVLAKSTEEENGNRIA ADDPEETLQKEQTEEAVPFDPKDINKEGEITSERTENTKLYYEGDGVYKQEVYLDPIH TKETPDADWEDISPELKESTSKQVETENAILNSDFQKQMKNGLYATFEHNDHKVTYSL AEAKGPNKTSLTPKDTSADYKTDSNEIVYPDVFPNIDLQTFTFNENIKEDLVLHQYNG YNTFTFQLKTDLQAKEQEDGSIDFSDEKGKVVFSVPKPFMTDSKLDELSGEVERSDKV SYKLEKNEEGYLLHLTADENWLKDPERVYPVSIDPSTSLSVSSDTFVMSAYPTTNYSA SSQKWDANLKAYVLKTGYYDKTTGTNYAFMKFNNLKPIQNMTVTKATLKTYVAHSYYG TKATGLWLDTVNSNYDNAKVTWNTKPASKNIGKADVHKGQWASYDVTAAVKSWNSGGA NYGFKLHTNGNGKEYWKKLISSANSANKPYIEVTYTIPKGNTPTIKAYHNGDSTGYFD ISWKKVEGAKGYKVWIYNGKEYQAISAGNVTSWSTKGKKIWPTSAEIASKRYKLHLDG KDGAELALDPSPVYKNSGGSYATSKNYWIGVSAIFDQGEGAMSAPAKPVIPNVGKAQA PSAKGYNNGNATGYFDLSWKAVSGATGYKVQVFNGKGFETLDLGNQTSWTTKGKKIWP TSAEIKAGKYALHLKDGSGAELPINPGPTYKNAGGDGAKRNYSFKIIAYNKDGEAIAS PAATPALPDIARPKNVTGYLYTNTKSSQTGYVNLIWEKVQNAKGYKVNIYNGKEYQSF DVGDADHWTTQNKNIWPTSEEIKAGSYKLHTDGKGGELALDPSPVYNNANGNYKGKKN YSFTLVAYDANGETIPTAPFNPTFHEGAEFLGTEEYWSIIDIPSGQLNGATGNVIVNE EDLSIDGRGPGLGLSRTYNSLDSSDHLFGQGWYADAETSVISTDGGAMYIDEDATTHR FTKKADGTYQPPTGVYLELTETADQFILKTKDQTNAYFNKKGGKLQKVVDGHNNATVY TYNDKNQLTAITDASGRKLTFTYDENGHVTSITGPKNKKVTYSYENDLLKKVTDTDGT VTSYDYDSEGRLVKQYSANSTEAKPVFTEYQYSGHRLEKAINAKKETYVYSYDADKKT LLMTQPNGRKVQYGYNEAGNPIQVIDDAEGLKITTNTKYEGNNVVEDVDPNDVGTGKA TESYQYDKDGNVTSVKDAYGTETYEYNKNNDVTKMKDTEGNVTDIAYDGLDAVSETDQ SGKSSSAAVYDKYGNQIQSSKDLSASTNILKDGSFEAQKSGWNLTASKDSGKISVIAD KSGVLSGSKALEVLSQSTSAGTDHGYSSATQTVELEPNTTYTLSGKIKTDLAKSRAYF NIDLRDKDQKRIQWIHNEYSALAGKNDWTKRQITFTTPANAGKAVVYMEVDHKDKDGK GKAWFDEVQLEKGEVSSSYNPVQNSSFTSATENWNVSGASVDSEEGFNDDVSLKAART SASQAGSVTKQTVVLGQSANDKPVYLTLTGMSKASSVKFTDEKDYSLQANVTYADGST GIYNAKFPSGTQEWNRAAVVIPKTKPINKVDISILFQKSATGTVWFDDIRLIEGSLLT KSTYDSNGNYVTKEEDELGYATSTDYDETGKKTSETDAKGEKTTYTYDQADQLTNMTL SNGTSILHSYDKEGNEVSKTIRAGADQTYKFEYDVMGKLVKTTDPLGNVLASEYDANS NLTKTISPNGNEVSLSYDGTDRVKSKSYNGTEKYIFTYDKNGNETSVVNKEQNTTKKR TFDNKNRLTELTDRGGSQTWTYPSDSDKLKTFSWIHGDQKGTNQFTYNKLDQMIEMKD STSSYSFDYDENGNVQTFITGNGGGTSFSYDERNLVSSLHIGDKNGGDILTESYEYDA NGNRTTINSSASGKVQYEYGKLNQLVKETHEDGTVIEYTYDGFGNRKTVTTIKDGSSK TVNASFNIMNQLTKVNDESISYDKNGNRTSDGKFTYTWDAEDNLTAVTKKGEDKPFAT YKYDEKGNRIQKTVNGKVTNYFYDGDSLNVLYETDADNNVTKSYTYGDSGQLLSYTEN GKKYFYHYNAHGDIIAISDSTGKTVAKYQYDAWGNPTKTEASDEVKDNRYRYAGYQYD EETGLYYLMARYYEPRNGVFLSLDPDPGSDGDSLDQNGYAYGNNNPVMNVDPDGHWVW LVVNAGFAAYDGYKAYKSGKGWKGAAWAAASNFGPGKIFKGASRAYKFTKKAVKITGH TRHGLNQSIGRNGGRGVNLRAKLNAVRSPKKVIKQPNGATKYVGKKATVVLNKRGKVI TAYGSSRAKGSKHVFHTHGKGNKSKRRR*" /label="wapA CDS" gene complement(3493834..3500838) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /label="wapA gene" misc_feature 3500845..3500859 /Source="Nicolas_upshift_promotors" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3500859 /Source="Nicolas_upshifts" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3500869..3500888) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3500884) /Source="Nicolas_upshifts" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3500903..3500910) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3501000..3501935) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391803.1" /db_xref="EnsemblGenomes-Gn:BSU39240" /db_xref="EnsemblGenomes-Tr:CAB15960" /db_xref="GOA:Q07835" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10796" /db_xref="UniProtKB/Swiss-Prot:Q07835" /translation="MQQDPSISSKQKSTAVIKMVISMVIFGSIGFFSEHTNLPSFELV FVRCLCATLFLGFCWLASGQYKTEKWSKRDVLQTLACGFFLVFNWVFLFKSFEETSVT IAISVYHLAPVLVLLLGSFFYREKLNVISVSSIIICFLGTALISGINGSTSLTQLMGS GIIWAVLAALFYAFTTLLGKGIHNLSPYTTTFLQTGLGVIILIPFIHFGAFADLSQGN WIMVVSTGIIHTGIVYLLFFDSLRFLSTKFISIIVFLDPAVAIVLDTVFTGFRPDLYQ TLGIVMIFAGMALTLVRRQGKANVTAEGTDIEQIQ*" /label="yxxF CDS" gene complement(3501000..3501935) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /label="yxxF gene" downshifts complement(3501221) /Source="Nicolas_upshifts" /id="D2038" /incds=1 /nref=1 /ntot=153 /MaxReadThrough="1.33481" /MaxDrop="2.42407" /score="29.0290332" /energy="-5.9" /TU="NA" /idTUdmin="U3098" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(3501936..3502056) /Source="Nicolas_S_feature" /locus_tag="new_4031646_4031766_c" /HighExp="T3.0H, T1.0H, T3.30H, LBGstat, T1.30H, T0.30H, T4.0H, M9-stat, T2.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="Sig-" /TUlongPSig="0.196" /label="S1512" CDS complement(3502087..3502533) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10913081, 12644671, 17210127" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 12644671, 17210127; Product type f: factor" /codon_start=1 /transl_table=11 /product="phosphate starvation protein (universal stress protein A family)" /protein_id="NP_391804.1" /db_xref="EnsemblGenomes-Gn:BSU39250" /db_xref="EnsemblGenomes-Tr:CAB15961" /db_xref="GOA:P42297" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11134" /db_xref="UniProtKB/Swiss-Prot:P42297" /translation="MFNKMLVAIDGSDMSAKALDAAVHLAKEQQAELSILHVGREAVV TTSSLTGIVYVPEHFIDEIRNEVKKEGLKILENAKEKAAEKGVQAETIYANGEPAHEI LNHAKEKGVSLIVVGSRGISGLKEMMLGSVSHKVSQLSTCPVLIVR*" /label="yxiE CDS" gene complement(3502087..3502533) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /label="yxiE gene" downshifts complement(3502101) /Source="Nicolas_upshifts" /id="D2039" /incds=0 /nref=22 /ntot=144 /MaxReadThrough="4.33955" /MaxDrop="6.75522" /score="45.6082379" /energy="-8.4" /TU="U3098" /idTUdmin="U3099" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3502570..3502589) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3502577) /Source="Nicolas_upshifts" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3502603..3502610) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3502636..3504045) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_391805.2" /db_xref="EnsemblGenomes-Gn:BSU39260" /db_xref="EnsemblGenomes-Tr:CAB15962" /db_xref="GOA:P40740" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG10935" /db_xref="UniProtKB/Swiss-Prot:P40740" /translation="MSSNEKRFPEGFLWGGAVAANQVEGAYNEGGKGLSTADVSPNGI MSPFDESMTSLNLYHNGIDFYHRYKEDIALFAEMGFKAFRTSIAWTRIFPNGDEEEPN EEGLRFYDDLFDELLKHHIEPVVTISHYEMPLGLVKNYGGWKNRKVIEFYERYAKTVF KRYQHKVKYWMTFNEINVVLHAPFTGGGLVFEEGENKLNAMYQAAHHQFVASALAVKA GHDIIPDSKIGCMIAATTTYPMTSKPEDVFAAMENERKTLFFSDVQARGAYPGYMKRY LAENNIEIEMAEGDEELLKEHTVDYIGFSYYMSMAASTDPEELAKSGGNLLGGVKNPY LKSSEWGWQIDPKGLRITLNTLYDRYQKPLFIVENGLGAVDKVEEDGTIQDDYRINYL RDHLIEAREAIADGVELIGYTSWGPIDLVSASTAEMKKRYGFIYVDRDNEGNGTFNRI KKKSFNWYQQVIATNGESL*" /label="bglH CDS" gene complement(3502636..3504045) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /label="bglH gene" CDS complement(3504068..3505897) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /EC_number="2.7.1.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17074746, 8626332" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17074746, 8626332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) beta-glucoside-specific enzyme IIBCA component" /protein_id="NP_391806.2" /db_xref="EnsemblGenomes-Gn:BSU39270" /db_xref="EnsemblGenomes-Tr:CAB15963" /db_xref="GOA:P40739" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011297" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10934" /db_xref="UniProtKB/Swiss-Prot:P40739" /translation="MDYDKLSKDILQLVGGEENVQRVIHCMTRLRFNLHDNAKADRSQ LEQLPGVMGTNISGEQFQIIIGNDVPKVYQAIVRHSNLSDEKSAGSSSQKKNVLSAVF DVISGVFTPILPAIAGAGMIKGLVALAVTFGWMAEKSQVHVILTAVGDGAFYFLPLLL AMSAARKFGSNPYVAAAIAAAILHPDLTALLGAGKPISFIGLPVTAATYSSTVIPILL SIWIASYVEKWIDRFTHASLKLIVVPTFTLLIVVPLTLITVGPLGAILGEYLSSGVNY LFDHAGLVAMILLAGTFSLIIMTGMHYAFVPIMINNIAQNGHDYLLPAMFLANMGQAG ASFAVFLRSRNKKFKSLALTTSITALMGITEPAMYGVNMRLKKPFAAALIGGAAGGAF YGMTGVASYIVGGNAGLPSIPVFIGPTFIYAMIGLVIAFAAGTAAAYLLGFEDVPSDG SQQPAVHEGSREIIHSPIKGEVKALSEVKDGVFSAGVMGKGFAIEPEEGEVVSPVRGS VTTIFKTKHAIGITSDQGAEILIHIGLDTVKLEGQWFTAHIKEGDKVAPGDPLVSFDL EQIKAAGYDVITPVIVTNTDQYSFSPVKEIGKVQPKEALLALS*" /label="bglP CDS" gene complement(3504068..3505897) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /label="bglP gene" promotor_no_box complement(3505889..3505989) /Source="Nicolas_upshift_promotors" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="promotor_no_box" upshifts complement(3505929) /Source="Nicolas_upshifts" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="upshifts" S_feature complement(3505931..3506123) /Source="Nicolas_S_feature" /locus_tag="new_4035641_4035833_c" /HighExp="Diami, T0.30H, B60, T0.0H, G150, M9-stat, T1.0H, T1.30H, Gly, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29980099999999998" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.998, 0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1513" promotor_-10 complement(3506104..3506123) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3506123) /Source="Nicolas_upshifts" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3506125..3506258) /Source="Nicolas_S_feature" /locus_tag="new_4035835_4035968_c" /HighExp="S2, HiTm, Sw, S8, M9-stat, Lbstat, S0, T2.0H, Mal, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1514" promotor_-35 complement(3506136..3506143) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3506280..3506588) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391807.1" /db_xref="EnsemblGenomes-Gn:BSU39280" /db_xref="EnsemblGenomes-Tr:CAB15964" /db_xref="SubtiList:BG11071" /db_xref="UniProtKB/Swiss-Prot:P40738" /translation="MLLINKQKDPVFQFLAGTFHQDIETPDDAIQELLIEESKEYLED AIVFLTDFIESEHSDNKKNDYIQSCADGVYLPAFNLEPIDWLKNVIVQIKKSLKKFKR *" /label="yxxE CDS" gene complement(3506280..3506588) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /label="yxxE gene" downshifts complement(3506303) /Source="Nicolas_upshifts" /id="D2040" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.99098" /MaxDrop="5.76651" /score="24.0715465" /energy="-21.3" /TU="U3101,U3102" /idTUdmin="U3101" /TUdmin="-3718" /isTUend="FALSE" /label="downshifts" CDS complement(3506634..3507077) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin factor of the RttD-RttE toxin-antitoxin system" /protein_id="NP_391808.1" /db_xref="EnsemblGenomes-Gn:BSU39290" /db_xref="EnsemblGenomes-Tr:CAB15965" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG11070" /db_xref="UniProtKB/Swiss-Prot:P40737" /translation="MSYNFIKSNKENDFYPVNQSEIEEVEKNLNLKLPSELVNFYLEV GYGFIKGSEFNTNRILDPYSVRDFRLRINDFEFYPDIEIYDEFENDKLIFFEGSESAL MSIELNDNNKNPIYYYDIQIATSLTEFLRKIEENDQYYLDLLDDE*" /label="rtbE CDS" gene complement(3506634..3507077) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /label="rtbE gene" CDS complement(3507074..3508783) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease toxin of the RtbD-RtbE toxin-antitoxin system" /protein_id="NP_391809.2" /db_xref="EnsemblGenomes-Gn:BSU39300" /db_xref="EnsemblGenomes-Tr:CAB15966" /db_xref="GOA:P42296" /db_xref="InterPro:IPR003615" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG11133" /db_xref="UniProtKB/Swiss-Prot:P42296" /translation="MKTLDVHALHEGIQHTIEKLDKQKQQLEKLEKSVEHLAGMKDAL KGKGGDAIRTFYEECHKPFLLFFGIFIDEYKKVLKQTQHAISSVESNSHGMIAEAFLS HDARHGVKHAREVTEQLTDAVNRQTSAIDHIVSLPTVNDSFFRMETEQAERLISDTLN KLFQFDGQQTQALEAAKSDFQTMKKYIDQLETMYTGPKIEITGYKSGSILKSQEEENI NQIFGAINPQMKQADDSPMEMMLKKLAENEKSKVDSVVKTGDSKKVSKNIIVINGKVY NTSEHREHIKTDFSNAEVKQVVYNDTLYNVYISGNDMKLEPVVSLSDIKVDENGYVKI LETAVELTGVYDLFKAATGRDPVSGEKVTGKDRVVASINSVPFAKIAKLEKLIDINKL INNGKKAKKASEVKNVAKDKGKIANDVSGSANKINSDLIKKYARDIEQRTGRELPKNQ IDKLKEALRNKEYKKMSPIETAKHRTKFDKVKNKVIKEWEENTGQKWPVYKENVVSEK TGKIIRKKGDKYDAHHIIENTFGGEHEWWNMHPAKFPNEHQAGIHGTGSPANELFKGG KKK*" /label="rtbD CDS" gene complement(3507074..3508783) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /label="rtbD gene" misc_feature complement(3507945..3507964) /Source="Nicolas_upshift_promotors" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3507953) /Source="Nicolas_upshifts" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="upshifts" CDS complement(3508803..3509072) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391810.1" /db_xref="EnsemblGenomes-Gn:BSU39310" /db_xref="EnsemblGenomes-Tr:CAB15967" /db_xref="InterPro:IPR020315" /db_xref="SubtiList:BG11132" /db_xref="UniProtKB/Swiss-Prot:P42295" /translation="MAQEIKMVYDTVKQGLSQLKNSAELKSSLPGHLSGRNHLNVVKS IEQLNKDIKELTEAYASVLAKHIAQTESAVNAMKETDENISSSMK*" /label="yxiC CDS" gene complement(3508803..3509072) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /label="yxiC gene" CDS complement(3509084..3509449) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391811.1" /db_xref="EnsemblGenomes-Gn:BSU39320" /db_xref="EnsemblGenomes-Tr:CAB15968" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG11131" /db_xref="UniProtKB/Swiss-Prot:P42294" /translation="MHSEMLLHSVKADLHEKQEQIHQLKRVLHEIRQIKHDFSEAQHL IHRPHLNREAWRGTHAERFEDIREGMNKAYQQIKSDQVSGIIESIEGKIHSLEGDVYS IRRQITRIEHEIEKEKHKK*" /label="yxiB CDS" gene complement(3509084..3509449) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /label="yxiB gene" S_feature complement(3509450..3509515) /Source="Nicolas_S_feature" /locus_tag="new_4039160_4039225_c" /HighExp="T-1.40H, T-3.40H, T2.30H, T-2.40H, T-0.40H, T1.0H, T-1.10H, T-5.40H, T3.30H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1515" promotor_-10 complement(3509502..3509521) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3509515) /Source="Nicolas_upshifts" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3509536..3509539) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3509756..3511165) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 18408032, 18607095, 20883454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 18408032, 18607095, 20883454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan endo-1,5-alpha-L-arabinosidase ([Ca(2+)-dependent]" /protein_id="NP_391812.2" /db_xref="EnsemblGenomes-Gn:BSU39330" /db_xref="EnsemblGenomes-Tr:CAB15969" /db_xref="GOA:P42293" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR023296" /db_xref="InterPro:IPR032291" /db_xref="PDB:2X8F" /db_xref="PDB:2X8S" /db_xref="PDB:2X8T" /db_xref="PDB:4COT" /db_xref="SubtiList:BG11130" /db_xref="UniProtKB/Swiss-Prot:P42293" /translation="MFNRLFRVCFLAALIMAFTLPNSVYAQKPIFKEVSVHDPSIIET NGTFYVFGSHLASAKSNDLMQWQQLTTSVSNDNPLIPNVYEELKETFEWAQSDTLWAA DVTQLADGKYYMYYNACRGDSPRSAMGVAVADNIEGPYKNKGIFLKSGMEGTSSDGTP YDATKHPNVVDPHTFFDKDGKLWMVYGSYSGGIFILEMNPKTGFPLPGQGYGKKLLGG NHSRIEGPYVLYNPDTQYYYLYLSYGGLDATGGYNIRVARSKKPDGPYYDAEGNPMLD VRGKGGTFFDDRSIEPYGVKLMGSYTFETENEKGTGYVSPGHNSAYYDEKTGRSYLIF HTRFPGRGEEHEVRVHQLFMNKDGWPVAAPYRYAGETLKEVKQKDITGTYKLIQHGKD ISADIKQTINIQLNKNHTISGEMTGTWRKTGKNTADITLAGKKYNGVFLRQWDSVREK NVMTFSVLNTSGEAVWGSK*" /label="abnB CDS" gene complement(3509756..3511165) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /label="abnB gene" downshifts complement(3509779) /Source="Nicolas_upshifts" /id="D2041" /incds=0 /nref=2 /ntot=38 /MaxReadThrough="0.825980000000001" /MaxDrop="3.49689" /score="16.962389" /energy="-7.9" /TU="NA" /idTUdmin="U3101" /TUdmin="-7194" /isTUend="FALSE" /label="downshifts" S_feature complement(3511166..3511275) /Source="Nicolas_S_feature" /locus_tag="new_4040876_4040985_c" /HighExp="S2, T2.30H, BC, T2.0H, M9-stat, T3.0H, T3.30H, T4.0H, S1, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1516" CDS complement(3511299..3511463) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097797.1" /db_xref="EnsemblGenomes-Gn:BSU39339" /db_xref="EnsemblGenomes-Tr:CAX52712" /db_xref="UniProtKB/Swiss-Prot:C0H3T6" /translation="MAVSQLMQNLTKQLLHVRERKTDVMQEGETAKELNYEGEDMQAT SSAQNRQTSV*" /label="yxzL CDS" gene complement(3511299..3511463) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /label="yxzL gene" promotor_-10 complement(3511348..3511366) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3511363) /Source="Nicolas_upshifts" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3511377..3511385) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3511655..3511674) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3511671) /Source="Nicolas_upshifts" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3511687..3511694) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3511703..3511710 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3511725..3511744 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3511728 /Source="Nicolas_upshifts" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="upshifts" CDS 3511782..3512228 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391813.2" /db_xref="EnsemblGenomes-Gn:BSU39340" /db_xref="EnsemblGenomes-Tr:CAB15970" /db_xref="GOA:P10943" /db_xref="InterPro:IPR015111" /db_xref="InterPro:IPR023552" /db_xref="InterPro:IPR036482" /db_xref="PDB:1VEA" /db_xref="PDB:1WMQ" /db_xref="PDB:1WPS" /db_xref="PDB:1WPT" /db_xref="PDB:1WPU" /db_xref="PDB:1WPV" /db_xref="PDB:1WRN" /db_xref="PDB:1WRO" /db_xref="PDB:1WRQ" /db_xref="PDB:3BOY" /db_xref="PDB:4H4L" /db_xref="SubtiList:BG10666" /db_xref="UniProtKB/Swiss-Prot:P10943" /translation="MTLHKERRIGRLSVLLLLNEAEESTQVEELERDGWKVCLGKVGS MDAHKVVAAIETASKKSGVIQSEGYRESHALYHATMEALHGVTRGEMLLGSLLRTVGL RFAVLRGNPYESEAEGDWIAVSLYGTIGAPIKGLEHETFGVGINHI*" /label="hutP CDS" gene 3511782..3512228 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /label="hutP gene" downshifts 3512233 /Source="Nicolas_upshifts" /id="D2042" /incds=0 /nref=157 /ntot=226 /MaxReadThrough="6.10706" /MaxDrop="5.43744" /score="3.19376411" /energy="-17.8" /TU="U3105" /idTUdmin="U3105" /TUdmin="-7018" /isTUend="FALSE" /label="downshifts" CDS 3512341..3513867 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /EC_number="4.3.1.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9535092, 10220322, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine ammonia-lyase (histidase)" /protein_id="NP_391814.1" /db_xref="EnsemblGenomes-Gn:BSU39350" /db_xref="EnsemblGenomes-Tr:CAB15971" /db_xref="GOA:P10944" /db_xref="InterPro:IPR001106" /db_xref="InterPro:IPR005921" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR022313" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10667" /db_xref="UniProtKB/Swiss-Prot:P10944" /translation="MVTLDGSSLTTADVARVLFDFEEAAASEESMERVKKSRAAVERI VRDEKTIYGINTGFGKFSDVLIQKEDSAALQLNLILSHACGVGDPFPECVSRAMLLLR ANALLKGFSGVRAELIEQLLAFLNKRVHPVIPQQGSLGASGDLAPLSHLALALIGQGE VFFEGERMPAMTGLKKAGIQPVTLTSKEGLALINGTQAMTAMGVVAYIEAEKLAYQTE RIASLTIEGLQGIIDAFDEDIHLARGYQEQIDVAERIRFYLSDSGLTTSQGELRVQDA YSLRCIPQVHGATWQTLGYVKEKLEIEMNAATDNPLIFNDGDKVISGGNFHGQPIAFA MDFLKIAISELANIAERRIERLVNPQLNDLPPFLSPHPGLQSGAMIMQYAAASLVSEN KTLAHPASVDSIPSSANQEDHVSMGTIAARHAYQVIANTRRVIAIEAICALQAVEYRG IEHAASYTKQLFQEMRKVVPSIQQDRVFSYDIERLTDWLKKESLIPDHQNKELRGMNI *" /label="hutH CDS" gene 3512341..3513867 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /label="hutH gene" CDS 3513864..3515522 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /EC_number="4.2.1.49" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15313616, 17395359, 22933560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urocanase" /protein_id="NP_391815.1" /db_xref="EnsemblGenomes-Gn:BSU39360" /db_xref="EnsemblGenomes-Tr:CAB15972" /db_xref="GOA:P25503" /db_xref="InterPro:IPR023636" /db_xref="InterPro:IPR023637" /db_xref="InterPro:IPR035085" /db_xref="InterPro:IPR035400" /db_xref="InterPro:IPR035401" /db_xref="InterPro:IPR036190" /db_xref="PDB:2FKN" /db_xref="SubtiList:BG10668" /db_xref="UniProtKB/Swiss-Prot:P25503" /translation="MTDVKKSIRANRGTELECLGWEQEAVLRMLRNNLDPEVAEKPED LIVYGGIGKAARDWDAFHAIEHSLKTLKNDETLLVQSGKPVGMFRTHPQAPRVLLANS VLVPKWADWEHFHELEKKGLMMYGQMTAGSWIYIGSQGILQGTYETFAELARQHFGGS LKGTLTLTAGLGGMGGAQPLSVTMNEGVVIAVEVDEKRIDKRIETKYCDRKTASIEEA LAWAEEAKLAGKPLSIALLGNAAEVHHTLLNRGVKIDIVTDQTSAHDPLIGYVPEGYS LDEADRLRQDTPELYVRLAKQSMKKHVEAMLAFQQKGSIVFDYGNNIRQVAKDEGLEN AFDFPGFVPAYIRPLFCEGKGPFRWAALSGDPADIYRTDALLKELFPTNKALHRWIDM AQEKVTFQGLPSRICWLGYGERKKMGLAINELVRTGELKAPVVIGRDHLDCGSVASPN RETEAMKDGSDAVGDWAVLNALVNTAAGASWVSFHHGGGVGMGYSLHAGMVAVADGSE LADERLARVLTSDPGMGIIRHADAGYERAVEVAKEQDIIVPMQK*" /label="hutU CDS" gene 3513864..3515522 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /label="hutU gene" CDS 3515535..3516800 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /EC_number="3.5.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16990261, 17395359, 18296777" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16990261, 17395359, 18296777; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazolone-5-propionate hydrolase" /protein_id="NP_391816.1" /db_xref="EnsemblGenomes-Gn:BSU39370" /db_xref="EnsemblGenomes-Tr:CAB15973" /db_xref="GOA:P42084" /db_xref="InterPro:IPR005920" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2BB0" /db_xref="PDB:2G3F" /db_xref="SubtiList:BG11100" /db_xref="UniProtKB/Swiss-Prot:P42084" /translation="MPKQIDTILINIGQLLTMESSGPRAGKSMQDLHVIEDAVVGIHE QKIVFAGQKGAEAGYEADEIIDCSGRLVTPGLVDPHTHLVFGGSREKEMNLKLQGISY LDILAQGGGILSTVKDTRAASEEELLQKAHFHLQRMLSYGTTTAEVKSGYGLEKETEL KQLRVAKKLHESQPVDLVSTFMGAHAIPPEYQNDPDDFLDQMLSLLPEIKEQELASFA DIFTETGVFTVSQSRRYLQKAAEAGFGLKIHADEIDPLGGAELAGKLKAVSADHLVGT SDEGIKKLAEAGTIAVLLPGTTFYLGKSTYARARAMIDEGVCVSLATDFNPGSSPTEN IQLIMSIAALHLKMTAEEIWHAVTVNAAYAIGKGEEAGQLKAGRSADLVIWQAPNYMY IPYHYGVNHVHQVMKNGTIVVNREGAILG*" /label="hutI CDS" gene 3515535..3516800 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /label="hutI gene" CDS 3516793..3517752 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /EC_number="3.5.3.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931887, 15355972, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formiminoglutamate hydrolase" /protein_id="NP_391817.1" /db_xref="EnsemblGenomes-Gn:BSU39380" /db_xref="EnsemblGenomes-Tr:CAB15974" /db_xref="GOA:P42068" /db_xref="InterPro:IPR005923" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="PDB:3M1R" /db_xref="SubtiList:BG11099" /db_xref="UniProtKB/Swiss-Prot:P42068" /translation="MDKYPFLREAGSSFKDRDVTKMSDLIATWDGQDIKGPALIGVPL SKSSISHSGASFAPGTIRQALKHSSAYSAELGEHVVSELLYDLGDIDIHVTDIVKSHH HIFQTMHALLSDHPDWVPLILGGDNSISYSTIKAIAQTKGTTAVIQFDAHHDVRNTED GGPTNGTPFRRLLDEEIIEGQHLIQLGIREFSNSQAYEAYAKKHNVNIHTMDMIREKG LIPTIKEILPVVQDKTDFIFISVDMDVLDQSHAPGCPAIGPGGLYTDELLEAVKYIAQ QPNVAGIEIVEVDPTLDFRDMTSRAAAHVLLHALKGMKLSPFK*" /label="hutG CDS" gene 3516793..3517752 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /label="hutG gene" S_feature 3517753..3517827 /Source="Nicolas_S_feature" /locus_tag="new_4047463_4047537" /HighExp="Sw, BC, T3.30H, T4.0H, T5.0H, T3.0H, T2.30H, S8, M9-stat, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1517" CDS 3517828..3519255 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="histidine degradation metabolites permease" /protein_id="NP_391818.2" /db_xref="EnsemblGenomes-Gn:BSU39390" /db_xref="EnsemblGenomes-Tr:CAB15975" /db_xref="GOA:P42087" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11101" /db_xref="UniProtKB/Swiss-Prot:P42087" /translation="MNLQENSSQQLKRTMKSRHLFMISLGGVIGTGLFLSTGYTLHQA GPGGTILAYVIGGLMMYLVMQCLGELSVAMPVTGSFQKYATTFIGPSTGFMVGIMYWI NWVVTVGSEFTASGILMQRWFPDSSVWMWSAIFAALLFICNAFSVKLFAETEFWFSSV KIVTIILFIILGGAAMFGLISLNGTADAPMLSNFTDHGGLFPNGFLAVFIAMISVSFA FSGTELIGVTAGESANPQKDIPRSIRNVAWRTVIFFIGAVFILSGLISWKDAGVIESP FVAVFAEIGIPYAADIMNFVILTALLSVANSGLYASTRMMWSLANENMISSRFKKVTS KGIPLNALMISMAVSCLSLVSSIVAPGTVYVVMVAIAGFAGVVVWMSIALSQLLFRKR FLKKGGDVKDLTFRTPLYPLMPIAALLLCSASCIGLAFDPNQRIALFCGVPCIILCYL IYHFKRNVTKAKKISQEEYPADHIL*" /label="hutM CDS" gene 3517828..3519255 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /label="hutM gene" downshifts 3519251 /Source="Nicolas_upshifts" /id="D2043" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="0.7432" /MaxDrop="6.18816" /score="8.21347356" /energy="-11.7" /TU="NA" /idTUdmin="U3105" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3519299..3520600) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /EC_number="2.4.2.2" /EC_number="2.4.2.3" /EC_number="2.4.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 15530033, 16469506, 21707079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 15530033, 16469506, 21707079; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside phosphorylase" /protein_id="NP_391819.2" /db_xref="EnsemblGenomes-Gn:BSU39400" /db_xref="EnsemblGenomes-Tr:CAB15976" /db_xref="GOA:P39142" /db_xref="InterPro:IPR000053" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR013102" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR017872" /db_xref="InterPro:IPR018090" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="InterPro:IPR036566" /db_xref="PDB:5EP8" /db_xref="SubtiList:BG10985" /db_xref="UniProtKB/Swiss-Prot:P39142" /translation="MRMVDIIIKKQNGKELTTEEIQFFVNGYTDGSIPDYQASALAMA IFFQDMSDRERADLTMAMVNSGETIDLSAIEGIKVDKHSTGGVGDTTTLVLAPLVAAL DVPVAKMSGRGLGHTGGTIDKLEAIMGFHVELTKDEFIKLVNRDKVAVIGQSGNLTPA DKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAAELA KAMVRIGNNVGRQTMAVISDMSQPLGFAIGNALEVKEAIDTLKGEGPEDLHELVLTLG SQMVVLAKKADTLDEARAKLEEVMKNGKALEKFKDFLKNQGGDSSIVDDPSKLPQAAY QIDVPAKEAGVVSEIVADEIGVAAMLLGAGRATKEDEIDLAVGIMLRKKVGDKVEKGE PLVTLYANRENVDEVIAKVYDNIRIAAEAKAPKLIHTLITE*" /label="pdp CDS" gene complement(3519299..3520600) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /label="pdp gene" downshifts complement(3519316) /Source="Nicolas_upshifts" /id="D2044" /incds=0 /nref=122 /ntot=224 /MaxReadThrough="1.27022" /MaxDrop="5.60021" /score="14.0361257" /energy="-13.1" /TU="NA" /idTUdmin="U3107" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(3520630..3521811) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8550462, 11065368, 12591866, 15849754, 16850406, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 11065368, 12591866, 15849754, 16850406, 25890046; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside Na+(H+) cotransporter" /protein_id="NP_391820.2" /db_xref="EnsemblGenomes-Gn:BSU39410" /db_xref="EnsemblGenomes-Tr:CAB15977" /db_xref="GOA:P39141" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG10984" /db_xref="UniProtKB/Swiss-Prot:P39141" /translation="MKYLIGIIGLIVFLGLAWIASSGKKRIKIRPIVVMLILQFILGY ILLNTGIGNFLVGGFAKGFGYLLEYAAEGINFVFGGLVNADQTTFFMNVLLPIVFISA LIGILQKWKVLPFIIRYIGLALSKVNGMGRLESYNAVASAILGQSEVFISLKKELGLL NQQRLYTLCASAMSTVSMSIVGAYMTMLKPEYVVTALVLNLFGGFIIASIINPYEVAK EEDMLRVEEEEKQSFFEVLGEYILDGFKVAVVVAAMLIGFVAIIALINGIFNAVFGIS FQGILGYVFAPFAFLVGIPWNEAVNAGSIMATKMVSNEFVAMTSLTQNGFHFSGRTTA IVSVFLVSFANFSSIGIIAGAVKGLNEKQGNVVARFGLKLLYGATLVSFLSAAIVGLI Y*" /label="nupC CDS" gene complement(3520630..3521811) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /label="nupC gene" S_feature complement(3521812..3521891) /Source="Nicolas_S_feature" /locus_tag="new_4051522_4051601_c" /HighExp="G150, G135, Oxctl, G180, Mt0, M40t45, Lbtran, M0t90, M40t90, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1518" CDS complement(3521892..3522563) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /EC_number="4.1.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 27033207" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 27033207; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyribose-phosphate aldolase" /protein_id="NP_391821.2" /db_xref="EnsemblGenomes-Gn:BSU39420" /db_xref="EnsemblGenomes-Tr:CAB15978" /db_xref="GOA:P39121" /db_xref="InterPro:IPR002915" /db_xref="InterPro:IPR011343" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR028581" /db_xref="SubtiList:BG10983" /db_xref="UniProtKB/Swiss-Prot:P39121" /translation="MSLANIIDHTALKPHTQKADILKLIEEAKTYKFASVCVNPTWVE LAAKELKGTGVDVCTVIGFPLGANTTETKAFETKDAISKGATEVDMVINIAALKDKED DVVEADIRGVVEAVAGKALVKVIIETCLLTDEEKERACRLAVSAGADFVKTSTGFSTG GATKEDIALMRKTVGPDIGVKASGGVRTKEDVDTMVEAGASRIGASAGVSIVKGENAS GGDNY*" /label="deoC CDS" gene complement(3521892..3522563) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /label="deoC gene" promotor_-35 3522512..3522515 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3522530 /Source="Nicolas_upshifts" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3522531..3522550 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3522591..3522610) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3522606) /Source="Nicolas_upshifts" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3522624..3522631) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3522669..3523610) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 10714997, 24863636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 10714997, 24863636; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of pyrmidine deoxyribonucleosides degradation (DeoR-dR5P)" /protein_id="NP_391822.1" /db_xref="EnsemblGenomes-Gn:BSU39430" /db_xref="EnsemblGenomes-Tr:CAB15979" /db_xref="GOA:P39140" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR013324" /db_xref="PDB:4OQP" /db_xref="PDB:4OQQ" /db_xref="SubtiList:BG10982" /db_xref="UniProtKB/Swiss-Prot:P39140" /translation="MDREKQQLSIEAARLYYQSDYSQQQIAEQLNISRPTVSRLLQYA KEKGYVQIRVMDPFEDLDALGSILEEKYGLLEAHVVFSPTPDYAGITHDLSRYGAEYM HETVKDGDIVGVSWGTTMYQIAQNMQPKQVKGVEVVQLKGGISHSRVNTYSAETIQLF AEAFQTMPRYLPLPVVFDNADVKRMVEKDRHIERIIEMGKQANIALFTVGTVRDEALL FRLGYFNEEEKALLKKQAVGDICSRFFDAKGNICSSAINDRTIGVELQDLRLKERSIL VAGGSRKVSSIHGALTGKYANVLIIDQHTARALVNDL*" /label="deoR CDS" gene complement(3522669..3523610) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /label="deoR gene" promotor_-10 complement(3523655..3523674) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3523661) /Source="Nicolas_upshifts" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3523663..3523743) /Source="Nicolas_S_feature" /locus_tag="new_4053373_4053453_c" /HighExp="Etha, Diami, Salt, MG 10, Gly, MG 60, G180, GM 60, G135, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.55204399999999998" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1519" promotor_-35 complement(3523690..3523693) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3523744..3524571) /gene="yxxB" /locus_tag="BSU_39440" /old_locus_tag="BSU39440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391823.2" /db_xref="EnsemblGenomes-Gn:BSU39440" /db_xref="EnsemblGenomes-Tr:CAB15980" /db_xref="GOA:P39139" /db_xref="InterPro:IPR009597" /db_xref="SubtiList:BG10981" /db_xref="UniProtKB/Swiss-Prot:P39139" /translation="MAVKDRYMSKIKQETKPWIKRFGRLGYFAFGGVFILLGVLAFMT AAGAGRAKDSSGALQTLSRMPYGSLLLFFIGIGLIGYVIWMVLSAIKDTEGHGNSRRG LSRRIGNFFSAAVYTSIAWNALRFVFGQGDGGTSEQTWSAYVLAQPFGQWLTGLTGAG FIVFAIVQFMKGVRAAFMKEFDTSKMNKQMICITKNTGRAGNIARAIIFSAIGYFLIK TAMTADPDDTRGFDGALAELAQQPHGKLILSILALGLILYGMYAIMKGIYQHMTWEK* " /label="yxxB CDS" gene complement(3523744..3524571) /gene="yxxB" /locus_tag="BSU_39440" /old_locus_tag="BSU39440" /label="yxxB gene" downshifts complement(3524543) /Source="Nicolas_upshifts" /id="D2045" /incds=0 /nref=6 /ntot=96 /MaxReadThrough="4.46865" /MaxDrop="3.48502" /score="14.6805498" /energy="-16" /TU="U3109,U3111" /idTUdmin="U3111" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3524596..3524614) /Source="Nicolas_upshift_promotors" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3524609) /Source="Nicolas_upshifts" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3524628..3524634) /Source="Nicolas_upshift_promotors" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3524644..3525756) /gene="yxeR" /locus_tag="BSU_39450" /old_locus_tag="BSU39450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1860825, 10746760, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ethanolamine permease" /protein_id="NP_391824.1" /db_xref="EnsemblGenomes-Gn:BSU39450" /db_xref="EnsemblGenomes-Tr:CAB15981" /db_xref="GOA:P54957" /db_xref="InterPro:IPR007441" /db_xref="SubtiList:BG11894" /db_xref="UniProtKB/Swiss-Prot:P54957" /translation="MTVNDAVVFILAAFLLWGAADYCLGNRWGLGERFADGFKAMGPL ALSMIGIVSLAPVLAAILIPIVAPFYTAIGADPSSFANTILAIDMGGYALAGEMAKDP QAGLFSWVFLGTMMGPAIVFTIPVALGIIEKEDHPYFAKGILIGLCTVPIGCLIGGLC AGFDIGMIGKNLLIPSLLSAVIAFGLWRYTDRMIQLFHLFGKAVSMVAIIGLAAVSVE TMTGIVLIPGMENVETGIQTTGTIAIALAGAFPMTAFITKTFKKPLQALGKCLHLDET ATAGLVTSLAHHIPMLASLKDMTPRGKVINVAFAVSGAFVLGSHLGFVAGMKKEMAAA MIIGKLAGGVTAAAAAAWMTPAQSAKQQKRISASHS*" /label="yxeR CDS" gene complement(3524644..3525756) /gene="yxeR" /locus_tag="BSU_39450" /old_locus_tag="BSU39450" /label="yxeR gene" CDS complement(3525826..3527163) /gene="yxeQ" /locus_tag="BSU_39460" /old_locus_tag="BSU39460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative catabolic enzyme" /protein_id="NP_391825.2" /db_xref="EnsemblGenomes-Gn:BSU39460" /db_xref="EnsemblGenomes-Tr:CAB15982" /db_xref="GOA:P54956" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11893" /db_xref="UniProtKB/Swiss-Prot:P54956" /translation="MSKQGLTAGLAEAVRTSQPEHSVDAIHEAKKGLLDFTAASFAGR EDKGIQKLLRLIEDEGGRPLVPVIGQGKKAAPLQSAMLNGFIAHALDFDDVHSDVRGH PSAVIVPALIASAARGHDERLLGAYVVGVEVMARLGESIGSRHYEKGWHNTGTLGAIA AACAVGYAEELTQEELEKAIGFAATQSAGMRVQFGTEMKPLHAGLAAQAGLLAVKLAQ SEFGGSRTALDGETGFFSLYGDVEKAQHTLLNDWGAPWRIVQPGLWFKIYPFCSAAHH AADAVRQLISEETISAANTERIEVIFPPGGDAALTERSPKAGEEGRFSVEYVIALALH GHGLTVEHFSSQPIPNGVQTTMGRIQRVYDNAIQPAPHAVPKGRFTIVRAYLSDGRIC EARVDCPKGAPGNELSEEDIIEKLTLTVPQEKARRIITAVEKADIKEFLAHIE*" /label="yxeQ CDS" gene complement(3525826..3527163) /gene="yxeQ" /locus_tag="BSU_39460" /old_locus_tag="BSU39460" /label="yxeQ gene" CDS complement(3527160..3528302) /gene="sndB" /locus_tag="BSU_39470" /old_locus_tag="BSU39470" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12193636, 16513748, 16885442, 23944997, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 16513748, 16885442, 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-sulfur-metabolite deacetylase" /protein_id="NP_391826.2" /db_xref="EnsemblGenomes-Gn:BSU39470" /db_xref="EnsemblGenomes-Tr:CAB15983" /db_xref="GOA:P54955" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="PDB:1YSJ" /db_xref="SubtiList:BG11892" /db_xref="UniProtKB/Swiss-Prot:P54955" /translation="MADKAFHTRLINMRRDLHEHPELSFQEVETTKKIRRWLEEEQIE ILDVPQLKTGVIAEIKGREDGPVIAIRADIDALPIQEQTNLPFASKVDGTMHACGHDF HTASIIGTAMLLNQRRAELKGTVRFIFQPAEEIAAGARKVLEAGVLNGVSAIFGMHNK PDLPVGTIGVKEGPLMASVDRFEIVIKGKGGHAGIPNNSIDPIAAAGQIISGLQSVVS RNISSLQNAVVSITRVQAGTSWNVIPDQAEMEGTVRTFQKEARQAVPEHMRRVAEGIA AGYGAQAEFKWFPYLPSVQNDGTFLNAASEAAARLGYQTVHAEQSPGGEDFALYQEKI PGFFVWMGTNGTEEWHHPAFTLDEEALTVASQYFAELAVIVLETIK*" /label="sndB CDS" gene complement(3527160..3528302) /gene="sndB" /locus_tag="BSU_39470" /old_locus_tag="BSU39470" /label="sndB gene" CDS complement(3528319..3529068) /gene="yxeO" /locus_tag="BSU_39480" /old_locus_tag="BSU39480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391827.1" /db_xref="EnsemblGenomes-Gn:BSU39480" /db_xref="EnsemblGenomes-Tr:CAB15984" /db_xref="GOA:P54954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11891" /db_xref="UniProtKB/Swiss-Prot:P54954" /translation="MITVKNIRKAFKDLVVLDGIDLEVKRGEVVAIIGPSGSGKSTLL RCLNLLERPDQGLIEIGEAKLNAEKFTRKEAHRLRQQTAMVFQNYNLFKNKTALQNIT EALIVAQHKPRDEAKRIGMEILKQVGLEHKADSYPITMSGGQQQRIGIARALAVNPHA ILLDEPTSALDPELVTGVLQVIKSIAEKQTTMIIVTHEMAFAKEVADQVIFMADGHII EQGTPEELFDHPKNERTKRFIKQVGEPAELI*" /label="yxeO CDS" gene complement(3528319..3529068) /gene="yxeO" /locus_tag="BSU_39480" /old_locus_tag="BSU39480" /label="yxeO gene" CDS complement(3529081..3529755) /gene="yxeN" /locus_tag="BSU_39490" /old_locus_tag="BSU39490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 15849754, 16513748, 16850406, 16885442; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391828.1" /db_xref="EnsemblGenomes-Gn:BSU39490" /db_xref="EnsemblGenomes-Tr:CAB15985" /db_xref="GOA:P54953" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11890" /db_xref="UniProtKB/Swiss-Prot:P54953" /translation="MNTIDWEFMISAFPTLIQALPITLFMAIAAMIFAIIGGLILALI TKNKIPVLHQLSKLYISFFRGVPTLVQLFLIYYGLPQLFPEMSKMTALTAAIIGLSLK NAAYLAEIFRAALNSVDDGQLEACLSVGMTKFQAYRRIILPQAIRNAIPATGNTFIGL LKETSLAFTLGVMEMFAQGKMYASGNLKYFETYLAVAIVYWVLTIIYSILQDLFERAM SKPYRT*" /label="yxeN CDS" gene complement(3529081..3529755) /gene="yxeN" /locus_tag="BSU_39490" /old_locus_tag="BSU39490" /label="yxeN gene" CDS complement(3529778..3530572) /gene="yxeM" /locus_tag="BSU_39500" /old_locus_tag="BSU39500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_391829.1" /db_xref="EnsemblGenomes-Gn:BSU39500" /db_xref="EnsemblGenomes-Tr:CAB15986" /db_xref="GOA:P54952" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11889" /db_xref="UniProtKB/Swiss-Prot:P54952" /translation="MKMKKWTVLVVAALLAVLSACGNGNSSSKEDDNVLHVGATGQSY PFAYKENGKLTGFDVEVMEAVAKKIDMKLDWKLLEFSGLMGELQTGKLDTISNQVAVT DERKETYNFTKPYAYAGTQIVVKKDNTDIKSVDDLKGKTVAAVLGSNHAKNLESKDPD KKINIKTYETQEGTLKDVAYGRVDAYVNSRTVLIAQIKKTGLPLKLAGDPIVYEQVAF PFAKDDAHDKLRKKVNKALDELRKDGTLKKLSEKYFNEDITVEQKH*" /label="yxeM CDS" gene complement(3529778..3530572) /gene="yxeM" /locus_tag="BSU_39500" /old_locus_tag="BSU39500" /label="yxeM gene" promotor_-35 3530144..3530153 /Source="Nicolas_upshift_promotors" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3530165 /Source="Nicolas_upshifts" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3530166..3530181 /Source="Nicolas_upshift_promotors" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3530597..3531094) /gene="snaB" /locus_tag="BSU_39510" /old_locus_tag="BSU39510" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12193636, 16513748, 16885442, 23944997, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 16513748, 16885442, 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur-containing aminoacid acetyltransferase" /protein_id="NP_391830.2" /db_xref="EnsemblGenomes-Gn:BSU39510" /db_xref="EnsemblGenomes-Tr:CAB15987" /db_xref="GOA:P54951" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11888" /db_xref="UniProtKB/Swiss-Prot:P54951" /translation="MKPRYRLAVERDAEQLLELTLRAYEPIRKLGIRFAAAHADLDLV LKNIRENACYVMEEDGRIIATITLRMPWGKQPGPYGVPHIWWFAVDPDTGKKGIGTKL LQWLEETILRDTLKVPFVSLGTADKHPWLIEMYERKGYVRSGEQDLGKGHITVYMKKQ LRHDL*" /label="snaB CDS" gene complement(3530597..3531094) /gene="snaB" /locus_tag="BSU_39510" /old_locus_tag="BSU39510" /label="snaB gene" CDS complement(3531108..3532433) /gene="yxeK" /locus_tag="BSU_39520" /old_locus_tag="BSU39520" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8892809, 12193636, 15294834, 16513748, 16885442, 23944997; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391831.1" /db_xref="EnsemblGenomes-Gn:BSU39520" /db_xref="EnsemblGenomes-Tr:CAB15988" /db_xref="GOA:P54950" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG11887" /db_xref="UniProtKB/Swiss-Prot:P54950" /translation="MTSKKKQIKLGVFLAGTGHHVASWRHPDAPSDASMNLDYFKELA KTAERGKLDMLFLADSLSIDSKSHPNVLTRFEPFTLLSALAQVTSKIGLTATASTTYS EPFHIARQFASLDHLSNGRAGWNVVTSSIESTALNFSGEKHLEHHLRYQRAEEFVEIV KGLWDSWEEDAFIRNKETGEFFDKEKMHELNHKGEYFSVRGPLNVSRTPQGQPVIIQA GSSGDGKALAAKTAEVIFTAQNHLESAQEFYQSIKEQAAEFGRDPEKIAIMPGIFPII ADTEEAAQAKYKELQDLIIPSVGLQILQNYLGGIDLSAYPLDGPLPKLDAEASNAVKS RFKLVQEMAERDNMTIRELYKYVAGSRGHHIFVGTPEQLADKMQEWVDTKACDGFNIM PPLLPEGIEVFVDQVVPILQERGVFRKEYEGTTLREHFGLEKPVNRYAK*" /label="yxeK CDS" gene complement(3531108..3532433) /gene="yxeK" /locus_tag="BSU_39520" /old_locus_tag="BSU39520" /label="yxeK gene" promotor_-10 complement(3532510..3532529) /Source="Nicolas_upshift_promotors" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3532514) /Source="Nicolas_upshifts" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3532543..3532550) /Source="Nicolas_upshift_promotors" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3532619..3532846) /gene="yxeJ" /locus_tag="BSU_39530" /old_locus_tag="BSU39530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_391832.2" /db_xref="EnsemblGenomes-Gn:BSU39530" /db_xref="EnsemblGenomes-Tr:CAB15989" /db_xref="SubtiList:BG11886" /db_xref="UniProtKB/Swiss-Prot:P54949" /translation="MSLINSHQSADSGLNIWSQLFFYTIVTASEWIGGLQKRRKGKGN GEILYEIIGRKLSLCFIRLSFLADIEVALVE*" /label="yxeJ CDS" gene complement(3532619..3532846) /gene="yxeJ" /locus_tag="BSU_39530" /old_locus_tag="BSU39530" /label="yxeJ gene" CDS complement(3532833..3533819) /gene="yxeI" /locus_tag="BSU_39540" /old_locus_tag="BSU39540" /EC_number="3.5.1.11" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15937167, 16511127, 18667582, 21978958" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937167, 16511127, 18667582, 21978958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin V amidase" /protein_id="NP_391833.2" /db_xref="EnsemblGenomes-Gn:BSU39540" /db_xref="EnsemblGenomes-Tr:CAB15990" /db_xref="GOA:P54948" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029132" /db_xref="PDB:2OQC" /db_xref="SubtiList:BG11885" /db_xref="UniProtKB/Swiss-Prot:P54948" /translation="MCTSLTLETADRKHVLARTMDFAFQLGTEVILYPRRYSWNSEAD GRAHQTQYAFIGMGRKLGNILFADGINESGLSCAALYFPGYAEYEKTIREDTVHIVPH EFVTWVLSVCQSLEDVKEKIRSLTIVEKKLDLLDTVLPLHWILSDRTGRNLTIEPRAD GLKVYDNQPGVMTNSPDFIWHVTNLQQYTGIRPKQLESKEMGGLALSAFGQGLGTVGL PGDYTPPSRFVRAVYLKEHLEPAADETKGVTAAFQILANMTIPKGAVITEEDEIHYTQ YTSVMCNETGNYYFHHYDNRQIQKVNLFHEDLDCLEPKVFSAKAEESIHELN*" /label="yxeI CDS" gene complement(3532833..3533819) /gene="yxeI" /locus_tag="BSU_39540" /old_locus_tag="BSU39540" /label="yxeI gene" downshifts complement(3532837) /Source="Nicolas_upshifts" /id="D2046" /incds=0 /nref=7 /ntot=52 /MaxReadThrough="2.95669" /MaxDrop="3.32309" /score="23.0334771" /energy="-17.9" /TU="NA" /idTUdmin="U3113" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3532970..3532979 /Source="Nicolas_upshift_promotors" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3532993..3533012 /Source="Nicolas_upshift_promotors" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3533003..3533636 /Source="Nicolas_S_feature" /locus_tag="new_4062713_4063346" /HighExp="S6, S7, S8, S5, Paraq, G150, H2O2, G180, LBGexp, Oxctl" /AntisenseName="yxeI" /AntisenseCor="0.24221971906572701" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S1520" upshifts 3533003 /Source="Nicolas_upshifts" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3533874..3533893) /Source="Nicolas_upshift_promotors" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3533885) /Source="Nicolas_upshifts" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3533908..3533915) /Source="Nicolas_upshift_promotors" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3533974..3534786) /gene="hadM" /locus_tag="BSU_39550" /old_locus_tag="BSU39550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 21575135, 23582330, 25527541, 25848029, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sugar-phosphate hydrolase (promiscuous)" /protein_id="NP_391834.1" /db_xref="EnsemblGenomes-Gn:BSU39550" /db_xref="EnsemblGenomes-Tr:CAB15991" /db_xref="GOA:P54947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11884" /db_xref="UniProtKB/Swiss-Prot:P54947" /translation="MYKLIAIDMDGTLLNDHHEVTEEVRDALHAAKAEGVKIVLCTGR PIGGVQRYLDELNLIEEGDYVIAYNGALVQNTHTNEVVSELSLGYDDLTSLYDLSLEL KTPMHFFDSSNLYTPNRDISEFTVYESYVTQVPLHFRKIDEVPKDILIPKVMFIDKPE NLSRVITSIPKDVREKYTMVRSAPFFYEILHSEASKGNAVRQLAQLLGIEQAEVMCIG DNGNDLTMIEWAGCGVAMANAIPEVLEAANFQTRSNNEHGVAHAIHELVLAK*" /label="hadM CDS" gene complement(3533974..3534786) /gene="hadM" /locus_tag="BSU_39550" /old_locus_tag="BSU39550" /label="hadM gene" promotor_-10 complement(3534816..3534835) /Source="Nicolas_upshift_promotors" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3534826..3535383) /gene="yxeG" /locus_tag="BSU_39560" /old_locus_tag="BSU39560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391835.1" /db_xref="EnsemblGenomes-Gn:BSU39560" /db_xref="EnsemblGenomes-Tr:CAB15992" /db_xref="GOA:P54946" /db_xref="SubtiList:BG11883" /db_xref="UniProtKB/Swiss-Prot:P54946" /translation="MRNQKAERLVAAGLVLHIIQWIFILWAFLKVKHLFSDYTIYNPN VISGSMQSLSFIQMMRAMMYSGAIVNYVLFFALVLLIYGIVLHAILIVLEMAAYVMIR RNPSSSWGFFFIAAGVKLAILNITGIPFLAAGFLLMKQKKAENGVKAERKRKPRLRIR RQGRRLNRIRRKPSLPVEYQKEKTI*" /label="yxeG CDS" gene complement(3534826..3535383) /gene="yxeG" /locus_tag="BSU_39560" /old_locus_tag="BSU39560" /label="yxeG gene" upshifts complement(3534839) /Source="Nicolas_upshifts" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3534850..3534857) /Source="Nicolas_upshift_promotors" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3535364..3535798) /gene="yxeF" /locus_tag="BSU_39570" /old_locus_tag="BSU39570" /function="18: Unknown function" /experiment="publication(s) with functional evidences, PMID:11160890, 22693626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 22693626; Product type s: structure" /codon_start=1 /transl_table=11 /product="lipocalin-like lipoprotein" /protein_id="NP_391836.1" /db_xref="EnsemblGenomes-Gn:BSU39570" /db_xref="EnsemblGenomes-Tr:CAB15993" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR021664" /db_xref="PDB:2JOZ" /db_xref="SubtiList:BG11882" /db_xref="UniProtKB/Swiss-Prot:P54945" /translation="MVIPLRNKYGILFLIAVCIMVSGCQQQKEETPFYYGTWDEGRAP GPTDGVKSATVTFTEDEVVETEVMEGRGEVQLPFMAYKVISQSTDGSIEIQYLGPYYP LKSTLKRGENGTLIWEQNGQRKTMTRIESKTGREEKDEKSKS*" /label="yxeF CDS" gene complement(3535364..3535798) /gene="yxeF" /locus_tag="BSU_39570" /old_locus_tag="BSU39570" /label="yxeF gene" promotor_-35 3535823..3535832 /Source="Nicolas_upshift_promotors" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3535842 /Source="Nicolas_upshifts" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3535845..3535864 /Source="Nicolas_upshift_promotors" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3535858) /Source="Nicolas_upshifts" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3535859..3536270) /Source="Nicolas_S_feature" /locus_tag="new_4065569_4065980_c" /HighExp="Salt, H2O2, Paraq, dia15, Oxctl, Diami, Cold, G150, Lbtran, LBGexp" /AntisenseName="yxeE" /AntisenseCor="-0.602938477548701" /AntisenseRegPval="-27.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.391, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1521" promotor_-10 complement(3535864..3535878) /Source="Nicolas_upshift_promotors" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3535887..3535891) /Source="Nicolas_upshift_promotors" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3535887..3536252 /gene="cotNE" /locus_tag="BSU_39580" /old_locus_tag="BSU39580" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 17905812, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 17905812, 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391837.1" /db_xref="EnsemblGenomes-Gn:BSU39580" /db_xref="EnsemblGenomes-Tr:CAB15994" /db_xref="SubtiList:BG11881" /db_xref="UniProtKB/Swiss-Prot:P54944" /translation="MNPYQYYSPQLPQQEPYYSHYEYNPYPQQDVYDPYQMDRQPALE RRIAALERQNEQQSRELTRLTNEDRRQNREIARIAEQVNQLSQAVERHTRRLNRLNQR LRTVENRLNIPFTAGEGGF*" /label="cotNE CDS" gene 3535887..3536252 /gene="cotNE" /locus_tag="BSU_39580" /old_locus_tag="BSU39580" /label="cotNE gene" downshifts 3536266 /Source="Nicolas_upshifts" /id="D2047" /incds=0 /nref=31 /ntot=47 /MaxReadThrough="1.46494" /MaxDrop="8.36553" /score="27.2157513" /energy="-12.2" /TU="U3115" /idTUdmin="U3115" /TUdmin="-38" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3536270..3536274) /Source="Nicolas_upshift_promotors" /id="U3117" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.390609390609391" /psig="0.390609390609391" /xcortree=290 /SigmaFactorBS="cgttttaacatataagaaatgcggaaaacgaaaccCtgagat gggagaatcgtattCCGCTttttttctttgtttcgctcagaaaccgccttcccctgca g" /listShort="S1521" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3536270) /Source="Nicolas_upshifts" /id="U3117" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.390609390609391" /psig="0.390609390609391" /xcortree=290 /SigmaFactorBS="cgttttaacatataagaaatgcggaaaacgaaaccCtgagat gggagaatcgtattCCGCTttttttctttgtttcgctcagaaaccgccttcccctgca g" /listShort="S1521" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3536272..3536358) /Source="Nicolas_S_feature" /locus_tag="new_4065982_4066068_c" /HighExp="Salt, S8, H2O2, dia15, S7, Paraq, Diami, aero, Oxctl, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1522" promotor_-10 complement(3536351..3536370) /Source="Nicolas_upshift_promotors" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3536358) /Source="Nicolas_upshifts" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3536384..3536391) /Source="Nicolas_upshift_promotors" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3536431..3536437 /Source="Nicolas_upshift_promotors" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3536451..3536462 /Source="Nicolas_upshift_promotors" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3536458 /Source="Nicolas_upshifts" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="upshifts" CDS 3536500..3536853 /gene="yxeD" /locus_tag="BSU_39590" /old_locus_tag="BSU39590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26506528" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391838.2" /db_xref="EnsemblGenomes-Gn:BSU39590" /db_xref="EnsemblGenomes-Tr:CAB15995" /db_xref="SubtiList:BG11880" /db_xref="UniProtKB/Swiss-Prot:P54943" /translation="MHNTQHGLQQLNQCRQTAQQLIQQTQQSSQQYRQMLHQEQQNIQ MLQQILNHEQQAAHTIQQALHGHDMAIQKCQQVVNMCNQMQQELTGQSSVMNTNVSTL PFGQNTTFQQQSYQQ*" /label="yxeD CDS" gene 3536500..3536853 /gene="yxeD" /locus_tag="BSU_39590" /old_locus_tag="BSU39590" /label="yxeD gene" downshifts 3536848 /Source="Nicolas_upshifts" /id="D2048" /incds=0 /nref=24 /ntot=55 /MaxReadThrough="0.20641" /MaxDrop="6.88486" /score="27.2157513" /energy="-12.2" /TU="NA" /idTUdmin="U3119" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(3536897..3537295) /gene="yxeC" /locus_tag="BSU_39600" /old_locus_tag="BSU39600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391839.2" /db_xref="EnsemblGenomes-Gn:BSU39600" /db_xref="EnsemblGenomes-Tr:CAB15996" /db_xref="GOA:P54942" /db_xref="SubtiList:BG11879" /db_xref="UniProtKB/Swiss-Prot:P54942" /translation="MGITKRGAAWEWLHSWWMLFIFMPFAITSFFAFLFIGIKVRNRK WIMYGIIYFFIFAFGFVLPDLPGVFIVVPLWAVTIIHGFKVRPLYLIQLDVYKDHVEA RAFAEARSEAESRFHAPKQSIQDIHIRKEQ*" /label="yxeC CDS" gene complement(3536897..3537295) /gene="yxeC" /locus_tag="BSU_39600" /old_locus_tag="BSU39600" /label="yxeC gene" downshifts complement(3536905) /Source="Nicolas_upshifts" /id="D2049" /incds=0 /nref=145 /ntot=243 /MaxReadThrough="1.70512" /MaxDrop="5.26494" /score="9.81431167" /energy="-12.2" /TU="NA" /idTUdmin="U3120" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3537310..3537329) /Source="Nicolas_upshift_promotors" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3537326) /Source="Nicolas_upshifts" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3537344..3537347) /Source="Nicolas_upshift_promotors" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3537383..3537390 /Source="Nicolas_upshift_promotors" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3537399..3537417) /Source="Nicolas_upshift_promotors" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3537405..3537424 /Source="Nicolas_upshift_promotors" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3537414 /Source="Nicolas_upshifts" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3537414) /Source="Nicolas_upshifts" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3537433..3537438) /Source="Nicolas_upshift_promotors" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3537473..3538438 /gene="frxB" /locus_tag="BSU_39610" /old_locus_tag="BSU39610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 16672620, 8388528, 19254027, 23924612, 25007174; Product type t : transporter" /codon_start=1 /transl_table=11 /product="desferrioxamine-and ferrichrome-binding transporter lipoprotein (shuttle system)" /protein_id="NP_391840.2" /db_xref="EnsemblGenomes-Gn:BSU39610" /db_xref="EnsemblGenomes-Tr:CAB15997" /db_xref="GOA:P54941" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG11878" /db_xref="UniProtKB/Swiss-Prot:P54941" /translation="MKKNILLVGMLVLLLMFVSACSGTASKGSSSDSASEKTEMRTYK SPKGNVNIPAHPKRIVTDFYAGELLSVGANVVGSGSWSFDNPFLKSKLKNVKDVGDPI SVEKVMELQPDLIVVMNEENVDKLKKIAPTVVIPYNTAKNVEDTVSMFGDIAGAKDQA KSFMADFNKKAEAAKKKIAGVIDKDATFGIYENTDKGEFWVFNDNGGRGGQAVYNALG LKAPEKIEQDVIKKGEMKQLSQEVIPEYAADYMFITDYNPKGESKTLDKLENSSIWKN LDAVKHNRVFINDFDSFYPYDPISVSKQVDIITDMLIKRAEENKK*" /label="frxB CDS" gene 3537473..3538438 /gene="frxB" /locus_tag="BSU_39610" /old_locus_tag="BSU39610" /label="frxB gene" upshifts 3537866 /Source="Nicolas_upshifts" /id="U3123" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.726273726273726" /psig="0.726273726273726" /xcortree=773 /SigmaFactorBS="cctgacttaattgttgtcatgaatgaagagaatgttgataaa ttaaagaaaatcgctccgactgttgTCATACCTTATAACACAGCgaaaaacgtagaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3537873..3537891 /Source="Nicolas_upshift_promotors" /id="U3123" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.726273726273726" /psig="0.726273726273726" /xcortree=773 /SigmaFactorBS="cctgacttaattgttgtcatgaatgaagagaatgttgataaa ttaaagaaaatcgctccgactgttgTCATACCTTATAACACAGCgaaaaacgtagaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 3538345 /Source="Nicolas_upshifts" /id="D2050" /incds=1 /nref=55 /ntot=191 /MaxReadThrough="6.103" /MaxDrop="4.3334" /score="22.3558496" /energy="-13.4" /TU="U3121" /idTUdmin="U3123" /TUdmin=193 /isTUend="FALSE" /label="downshifts" downshifts 3538416 /Source="Nicolas_upshifts" /id="D2051" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="4.41732" /MaxDrop="3.7101" /score="22.3558496" /energy="-13.4" /TU="U3121" /idTUdmin="U3123" /TUdmin=264 /isTUend="FALSE" /label="downshifts" S_feature 3538461..3539257 /Source="Nicolas_S_feature" /locus_tag="new_4068171_4068967" /HighExp="H2O2, Paraq, Lbexp, dia0, LBGexp, G150, B36, dia15, B60, GM 25" /AntisenseName="yxeA" /AntisenseCor="0.20524492145617201" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1523" CDS complement(3538479..3538826) /gene="yxeA" /locus_tag="BSU_39620" /old_locus_tag="BSU39620" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391841.1" /db_xref="EnsemblGenomes-Gn:BSU39620" /db_xref="EnsemblGenomes-Tr:CAB15998" /db_xref="InterPro:IPR006542" /db_xref="InterPro:IPR036166" /db_xref="PDB:3NPP" /db_xref="SubtiList:BG11877" /db_xref="UniProtKB/Swiss-Prot:P54940" /translation="MKKAMAILAVLAAAAVICGLLFFHNDVTDRFNPFIHQQDVYVQI DRDGRHLSPGGTEYTLDGYNASGKKEEVTFFAGKELRKNAYLKVKAKGKYVETWEEVK FEDMPDSVQSKLK*" /label="yxeA CDS" gene complement(3538479..3538826) /gene="yxeA" /locus_tag="BSU_39620" /old_locus_tag="BSU39620" /label="yxeA gene" downshifts complement(3538492) /Source="Nicolas_upshifts" /id="D2052" /incds=0 /nref=2 /ntot=78 /MaxReadThrough="1.28842" /MaxDrop="2.99568" /score="38.5550476" /energy="-11.6" /TU="NA" /idTUdmin="U3120" /TUdmin="-1584" /isTUend="FALSE" /label="downshifts" CDS complement(3538840..3540708) /gene="tpeM" /locus_tag="BSU_39630" /old_locus_tag="BSU39630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15289557, 15849754, 15870467, 16850406, 21078927, 28472044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15289557, 15849754, 15870467, 16850406, 21078927, 28472044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease); efflux of cationic peptides" /protein_id="NP_391842.2" /db_xref="EnsemblGenomes-Gn:BSU39630" /db_xref="EnsemblGenomes-Tr:CAB15999" /db_xref="GOA:P42424" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG11129" /db_xref="UniProtKB/Swiss-Prot:P42424" /translation="MTFLQFAYKNVTRNKRAYLAFFLSSAFSVLIFFTFAMFLFHPAL KEGYLNNIAKKGLTAAEWMIFVFSFLFVLYSVNAFLKSRNKEFGILLMQGITPGQLRK LITAENMIIGVMSIAAGIIGGFIFSKTFFTVGAYILEMDALPLYMPWKALGITACGFL LLFFFLSQFTILFVRSNTVIKLIKGTGKVKPEPKPSVLLSLFGIACLCGGYGMVLKGN VHGAEPFIILLLTVIGTYFFFSQSSIWILRALKKWKTFYLRGKNIIWVSDLVYRLKDN ARLFFIVSIISAVAFTATGVLAMYKSTVGAEESAYEMEYLSYSNNPKEQTHLKDIDHE LKTHGFTYTKDKIDVSYVRYQEGETVPPVYMISESDAAKYFHVKVNGLKEDEAVYFPG TYDRNFKNEAPDQLKLLNQKGELSDQKLSVKEVKKPLISLNAIIAVNDQTFDQLKSLG DKASLYGYSYDHWKDSLEISQSLQNEIYGNYIDVHSDFASKAGTYYDTVQLPSLSLFI GLFIAIVFFVAAASFLYFRLFTDLDEDRERYRSLAKIGLSEREMAQSVTIQLAILFFF PFVIAVMHTLFALRTLAVEGYSDVAGPLSLTIGGFFIFQLLFFLAVRSSYLKKMNK*" /label="tpeM CDS" gene complement(3538840..3540708) /gene="tpeM" /locus_tag="BSU_39630" /old_locus_tag="BSU39630" /label="tpeM gene" CDS complement(3540683..3541456) /gene="tpeL" /locus_tag="BSU_39640" /old_locus_tag="BSU39640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15289557, 15870467, 17600057, 21078927, 28472044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15289557, 15870467, 17600057, 21078927, 28472044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein); efflux ofcationic peptides" /protein_id="NP_391843.2" /db_xref="EnsemblGenomes-Gn:BSU39640" /db_xref="EnsemblGenomes-Tr:CAB16000" /db_xref="GOA:P42423" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11128" /db_xref="UniProtKB/Swiss-Prot:P42423" /translation="MANMLEVKHINKTYKGQVSYQALKQISFSIEEGEFTAVMGPSGS GKTTLLNIISTIDRPDSGDILINGENPHRLKRTKLAHFRRKQLGFVFQDFNLLDTLTI GENIMLPLTLEKEAPSVMEEKLHGIAAKLGIENLLNKRTFEVSGGQRQRAAIARAVIH KPSLILADEPTGNLDSKATKDVMETLQSLNRDDHVTALMVTHDPVSASYCRRVIFIKD GELFNEIYRGENRQVFYEQILDVLSMLGGNANDLSSVRL*" /label="tpeL CDS" gene complement(3540683..3541456) /gene="tpeL" /locus_tag="BSU_39640" /old_locus_tag="BSU39640" /label="tpeL gene" CDS complement(3541600..3542577) /gene="tpeK" /locus_tag="BSU_39650" /old_locus_tag="BSU39650" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15289557, 15870467, 21283517, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15289557, 15870467, 21283517, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxdJ]" /protein_id="NP_391844.1" /db_xref="EnsemblGenomes-Gn:BSU39650" /db_xref="EnsemblGenomes-Tr:CAB16001" /db_xref="GOA:P42422" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11127" /db_xref="UniProtKB/Swiss-Prot:P42422" /translation="MKLFLRSHAVLILLFLLQGLFVFFYYWFAGLHSFSHLFYILGVQ LLILAGYLAYRWYKDRGVYHWLSSGQEGTDIPYLGSSVFCSELYEKQMELIRLQHQKL HETEAKLDARVTYMNQWVHQVKTPLSVINLIIQEEDEPVFEQIKKEVRQIEFGLETLL YSSRLDLFERDFKIEAVSLSELLQSVIQSYKRFFIQYRVYPKMNVCDDHQIYTDAKWL KFAIGQVVTNAVKYSAGKSDRLELNVFCDEDRTVLEVKDYGVGIPSQDIKRVFDPYYT GENGRRFQESTGIGLHLVKEITDKLNHTVDISSSPGEGTSVRFSFLTKM*" /label="tpeK CDS" gene complement(3541600..3542577) /gene="tpeK" /locus_tag="BSU_39650" /old_locus_tag="BSU39650" /label="tpeK gene" CDS complement(3542574..3543263) /gene="tpeJ" /locus_tag="BSU_39660" /old_locus_tag="BSU39660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15289557, 15870467, 21283517, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15289557, 15870467, 21283517, 25875741; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [TpeK(YxdK)]" /protein_id="NP_391845.1" /db_xref="EnsemblGenomes-Gn:BSU39660" /db_xref="EnsemblGenomes-Tr:CAB16002" /db_xref="GOA:P42421" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11126" /db_xref="UniProtKB/Swiss-Prot:P42421" /translation="MNKIMIVEDSEDIRGLLQNYLEKYGYQTVVAADFTAVLDVFLRE KPDVVLLDINLPAYDGYYWCRQIRQHSTSPIIFISARSGEMDQVMAIENGGDDYIEKP FSYDIVLAKIKSQIRRAYGEYAAKQGEKVVEYAGVQLFVERFELRFQDEKSELSKKES KLLEVLLERGEKVTSRDRLMEKTWDTDIFIDDNTLNVYITRLRKKLRELNAPVSIEAV RGEGYQLRAQS*" /label="tpeJ CDS" gene complement(3542574..3543263) /gene="tpeJ" /locus_tag="BSU_39660" /old_locus_tag="BSU39660" /label="tpeJ gene" promotor_-10 complement(3543290..3543309) /Source="Nicolas_upshift_promotors" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3543308) /Source="Nicolas_upshifts" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3543324..3543330) /Source="Nicolas_upshift_promotors" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3543371..3544243) /gene="iolJ" /locus_tag="BSU_39670" /old_locus_tag="BSU39670" /EC_number="4.1.2.29" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9226270, 10658656, 11325924, 18310071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9226270, 10658656, 11325924, 18310071; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-deoxy-5-keto-D-gluconic acid 6-phosphate aldolase" /protein_id="NP_391846.1" /db_xref="EnsemblGenomes-Gn:BSU39670" /db_xref="EnsemblGenomes-Tr:CAB16003" /db_xref="GOA:P42420" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11125" /db_xref="UniProtKB/Swiss-Prot:P42420" /translation="MAFVSMKELLEDAKREQYAIGQFNINGLQWTKAILQAAQKEQSP VIAAASDRLVDYLGGFKTIAAMVGALIEDMAITVPVVLHLDHGSSAERCRQAIDAGFS SVMIDGSHQPIDENIAMTKEVTDYAAKHGVSVEAEVGTVGGMEDGLVGGVRYADITEC ERIVKETNIDALAAALGSVHGKYQGEPNLGFKEMEAISRMTDIPLVLHGASGIPQDQI KKAITLGHAKININTECMVAWTDETRRMFQENSDLYEPRGYLTPGIEAVEETVRSKMR EFGSAGKAAKQQVG*" /label="iolJ CDS" gene complement(3543371..3544243) /gene="iolJ" /locus_tag="BSU_39670" /old_locus_tag="BSU39670" /label="iolJ gene" downshifts complement(3543375) /Source="Nicolas_upshifts" /id="D2053" /incds=0 /nref=89 /ntot=172 /MaxReadThrough="3.05314" /MaxDrop="6.87265" /score="26.7325466" /energy="-8.2" /TU="NA" /idTUdmin="U3126" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3544264..3545100) /gene="iolI" /locus_tag="BSU_39680" /old_locus_tag="BSU39680" /EC_number="5.3.99.11" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 17619021, 16461681, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 17619021, 16461681, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inosose isomerase" /protein_id="NP_391847.1" /db_xref="EnsemblGenomes-Gn:BSU39680" /db_xref="EnsemblGenomes-Tr:CAB16004" /db_xref="GOA:P42419" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="PDB:1I60" /db_xref="PDB:1I6N" /db_xref="SubtiList:BG11124" /db_xref="UniProtKB/Swiss-Prot:P42419" /translation="MKLCFNEATTLENSNLKLDLELCEKHGYDYIEIRTMDKLPEYLK DHSLDDLAEYFQTHHIKPLALNALVFFNNRDEKGHNEIITEFKGMMETCKTLGVKYVV AVPLVTEQKIVKEEIKKSSVDVLTELSDIAEPYGVKIALEFVGHPQCTVNTFEQAYEI VNTVNRDNVGLVLDSFHFHAMGSNIESLKQADGKKIFIYHIDDTEDFPIGFLTDEDRV WPGQGAIDLDAHLSALKEIGFSDVVSVELFRPEYYKLTAEEAIQTAKKTTVDVVSKYF SM*" /label="iolI CDS" gene complement(3544264..3545100) /gene="iolI" /locus_tag="BSU_39680" /old_locus_tag="BSU39680" /label="iolI gene" S_feature complement(3545101..3545185) /Source="Nicolas_S_feature" /locus_tag="new_4074811_4074895_c" /HighExp="M40t90, M0t90, BI, Sw, BC, T5.0H, T0.30H, T4.0H, T3.30H, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.101524" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1524" CDS complement(3545186..3546055) /gene="iolH" /locus_tag="BSU_39690" /old_locus_tag="BSU39690" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9887260, 11566986, 12112707, 23874669; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_391848.1" /db_xref="EnsemblGenomes-Gn:BSU39690" /db_xref="EnsemblGenomes-Tr:CAB16005" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11123" /db_xref="UniProtKB/Swiss-Prot:P42418" /translation="MKLALDPSMYRDDLTLEEMVYKTAELGYEYIELSPREDFCPFYK YPKVDSAKIKQLKRLLRDTGVKLSSLLPLYHWAGPDEDRRQAAVRNWKRAIEIAVELE VDLMNSEFSGSKYDPLTSEEKFIKSMDELLPVFEKEGIKLNLQAHPYDFIETHKGAMD MIRALDKDWINLVYSTAHTFFYDDGKGDIETMFDEAGDRLTHVLFADTYNHKAAHGLR YIVNPPDAKVTVHQHLDIGQGEVDFDTIFRKLREMKFDGIATNAVFAWVDERADESSR FMLKKMKEELGLA*" /label="iolH CDS" gene complement(3545186..3546055) /gene="iolH" /locus_tag="BSU_39690" /old_locus_tag="BSU39690" /label="iolH gene" CDS complement(3546075..3547109) /gene="iolG" /locus_tag="BSU_39700" /old_locus_tag="BSU39700" /EC_number="1.1.1.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:112095, 11274120, 15678175, 9226270, 16461681, 18310071, 22720735, 25482235, 28431560" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 112095, 11274120, 15678175, 9226270, 16461681, 18310071, 22720735, 25482235, 28431560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase" /protein_id="NP_391849.2" /db_xref="EnsemblGenomes-Gn:BSU39700" /db_xref="EnsemblGenomes-Tr:CAB16006" /db_xref="GOA:P26935" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR023794" /db_xref="InterPro:IPR036291" /db_xref="PDB:3MZ0" /db_xref="PDB:3NT2" /db_xref="PDB:3NT4" /db_xref="PDB:3NT5" /db_xref="PDB:3NTO" /db_xref="PDB:3NTQ" /db_xref="PDB:3NTR" /db_xref="PDB:4L8V" /db_xref="PDB:4L9R" /db_xref="SubtiList:BG10669" /db_xref="UniProtKB/Swiss-Prot:P26935" /translation="MSLRIGVIGTGAIGKEHINRITNKLSGAEIVAVTDVNQEAAQKV VEQYQLNATVYPNDDSLLADENVDAVLVTSWGPAHESSVLKAIKAQKYVFCEKPLATT AEGCMRIVEEEIKVGKRLVQVGFMRRYDSGYVQLKEALDNHVIGEPLMIHCAHRNPTV GDNYTTDMAVVDTLVHEIDVLHWLVNDDYESVQVIYPKKSKNALPHLKDPQIVVIETK GGIVINAEIYVNCKYGYDIQCEIVGEDGIIKLPEPSSISLRKEGRFSTDILMDWQRRF VAAYDVEIQDFIDSIQKKGEVSGPTAWDGYIAAVTTDACVKAQESGQKEKVELKEKPE FYQSFTTVQN*" /label="iolG CDS" gene complement(3546075..3547109) /gene="iolG" /locus_tag="BSU_39700" /old_locus_tag="BSU39700" /label="iolG gene" CDS complement(3547132..3548448) /gene="iolF" /locus_tag="BSU_39710" /old_locus_tag="BSU39710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="inositol transport protein" /protein_id="NP_391850.2" /db_xref="EnsemblGenomes-Gn:BSU39710" /db_xref="EnsemblGenomes-Tr:CAB16007" /db_xref="GOA:P42417" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11122" /db_xref="UniProtKB/Swiss-Prot:P42417" /translation="MGNTNGDSAFNKRTIAAALANYIDAGSIVAGSAGLSLWVSYLKL SDTQIGLLGALSANAISAAVGALLGGFLADKVGRKAVYTNSMLVYALGICLVLFGVNF PMLLSGYIIIGLSVGADITASWTIIAENAPKKNRARHCGVAQVAWAAGAVVVLLLSVL AGDLGLLGNKIVFAHLLVIALITYILRIRLPESDAWQTKNQPEEAQAEKPAVLNKTSY FDLLKPMYLKSILFLMGVYLVWNLAAGVMGFFMPYIYQQVGGVSANMANLLQMGLFIF TGLGVALIFMPFADKYRKTVFGIAAFMAVIGWTLFLLPVEGLPILLLFIVVIGINNGA GQQANYQLWASEIFPTQYRASAQGLMFFLVRISIGIWSLFVPMIITNFGIGTMAAILL GCVTASMIIGLLFAPNTSGKSLEQIQEELYGSPQSQVKKGTESKIM*" /label="iolF CDS" gene complement(3547132..3548448) /gene="iolF" /locus_tag="BSU_39710" /old_locus_tag="BSU39710" /label="iolF gene" CDS complement(3548463..3549356) /gene="iolE" /locus_tag="BSU_39720" /old_locus_tag="BSU39720" /EC_number="4.2.1.44" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9226270, 14993306, 22720735, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9226270, 14993306, 22720735, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inosose dehydratase" /protein_id="NP_391851.1" /db_xref="EnsemblGenomes-Gn:BSU39720" /db_xref="EnsemblGenomes-Tr:CAB16008" /db_xref="GOA:P42416" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR023952" /db_xref="InterPro:IPR030823" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11121" /db_xref="UniProtKB/Swiss-Prot:P42416" /translation="MGKNEILWGIAPIGWRNDDMPEIGAGNTLQHLLSDIVVARFQGT EVGGFFPEPAILNKELKLRNLRIAGKWFSSFILRDGLGEAAKTFTLHCEYLQQVNADV AVVSEQTYSVQSLEKNVFTEKPHFTDDEWERLCEGLNHLGEIAAQHGLKLVYHHHLGT GVQTAEEVDRLMAGTDPAHVHLLYDTGHAYISDGDYMGMLEKHIGRIKHVHFKDARLN VMEQCRLEGQSFRQSFLKGMFTVPGDGCIDFREVYQLLLKHSYSGWIVIEAEQDPDVA NPLEYALIARNYIDQQLLDLA*" /label="iolE CDS" gene complement(3548463..3549356) /gene="iolE" /locus_tag="BSU_39720" /old_locus_tag="BSU39720" /label="iolE gene" CDS complement(3549373..3551286) /gene="iolD" /locus_tag="BSU_39730" /old_locus_tag="BSU39730" /EC_number="3.7.1.22" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase" /protein_id="NP_391852.2" /db_xref="EnsemblGenomes-Gn:BSU39730" /db_xref="EnsemblGenomes-Tr:CAB16009" /db_xref="GOA:P42415" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR023757" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR030817" /db_xref="SubtiList:BG11120" /db_xref="UniProtKB/Swiss-Prot:P42415" /translation="MGKKIRLTTAQALIKFLNQQYIHVDGKEEPFVEGIFTIFGHGNV LGIGQALEQDAGHLKVYQGKNEQGMAHAAMAYSKQMLRRKIYAVSTSVGPGAANLVAA AGTALANNIPVLLIPADTFATRQPDPVLQQMEQEYSAAITTNDALKPVSRYWDRITRP EQLMSSLLRAFEVMTDPAKAGPATICISQDVEGEAYDFDESFFVKRVHYIDRMQPSER ELQGAAELIKSSKKPVILVGGGAKYSGARDELVAISEAYNIPLVETQAGKSTVEADFA NNLGGMGITGTLAANKAARQADLIIGIGTRYTDFATSSKTAFDFDKAKFLNINVSRMQ AYKLDAFQVVADAKVTLGKLHGLLEGYESEFGTTIRELKDEWLAERERLSKVTFKREA FDPEIKNHFSQEVLNEYADALNTELPQTTALLTINETIPEDSVIICSAGSLPGDLQRL WHSNVPNTYHLEYGYSCMGYEVSGTLGLKLAHPDREVYSIVGDGSFLMLHSELITAIQ YNKKINVLLFDNSGFGCINNLQMDHGSGSYYCEFRTDDNQILNVDYAKVAEGYGAKTY RANTVEELKAALEDAKKQDVSTLIEMKVLPKTMTDGYDSWWHVGVAEVSEQESVQKAY EAKEKKLESAKQY*" /label="iolD CDS" gene complement(3549373..3551286) /gene="iolD" /locus_tag="BSU_39730" /old_locus_tag="BSU39730" /label="iolD gene" CDS complement(3551319..3552296) /gene="iolC" /locus_tag="BSU_39740" /old_locus_tag="BSU39740" /EC_number="2.7.1.92" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-deoxy-5-keto-D-gluconic acid kinase" /protein_id="NP_391853.1" /db_xref="EnsemblGenomes-Gn:BSU39740" /db_xref="EnsemblGenomes-Tr:CAB16010" /db_xref="GOA:P42414" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR022841" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="InterPro:IPR030830" /db_xref="SubtiList:BG11119" /db_xref="UniProtKB/Swiss-Prot:P42414" /translation="MKYTFNEEKAFDIVAIGRACIDLNAVEYNRPMEETMTFSKYVGG SPANIAIGSAKLGLKAGFIGKIPDDQHGRFIESYMRKTGVDTTQMIVDQDGHKAGLAF TEILSPEECSILMYRDDVADLYLEPSEVSEDYIANAKMLLVSGTALAKSPSREAVLKA VQYAKKHQVKVVFELDYRPYTWQSSDETAVYYSLVAEQSDIVIGTRDEFDVMENRTGG SNEESVNHLFGHSADLVVIKHGVEGSYAYSKSGEVFRAQAYKTKVLKTFGAGDSYASA FIYGLVSGKDIETALKYGSASASIVVSKHSSSEAMPTAEEIEQLIEAQS*" /label="iolC CDS" gene complement(3551319..3552296) /gene="iolC" /locus_tag="BSU_39740" /old_locus_tag="BSU39740" /label="iolC gene" CDS complement(3552320..3553135) /gene="iolB" /locus_tag="BSU_39750" /old_locus_tag="BSU39750" /EC_number="5.3.1.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-deoxy-D-glucuronic acid isomerase" /protein_id="NP_391854.2" /db_xref="EnsemblGenomes-Gn:BSU39750" /db_xref="EnsemblGenomes-Tr:CAB16011" /db_xref="GOA:P42413" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR023770" /db_xref="InterPro:IPR024203" /db_xref="SubtiList:BG11118" /db_xref="UniProtKB/Swiss-Prot:P42413" /translation="MSYLLRKPQSHEVSNGVKLVHEVTTSNSDLTYVEFKVLDLASGS SYTEELKKQEICIVAVTGKITVTDHESTFENIGTRESVFERKPTDSVYISNDRAFEIT AVSDARVALCYSPSEKQLPTKLIKAEDNGIEHRGQFSNKRTVHNILPDSDPSANSLLV VEVYTDSGNWSSYPPHKHDQDNLPEESFLEETYYHELDPGQGFVFQRVYTDDRSIDET MTVGNENVVIVPAGYHPVGVPDGYTSYYLNVMAGPTRKWKFYNDPAHEWILER*" /label="iolB CDS" gene complement(3552320..3553135) /gene="iolB" /locus_tag="BSU_39750" /old_locus_tag="BSU39750" /label="iolB gene" S_feature complement(3553136..3553209) /Source="Nicolas_S_feature" /locus_tag="new_4082846_4082919_c" /HighExp="M40t90, M0t90, Lbtran, BI, Mt0, T0.30H, Sw, BC, S1, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1525" CDS complement(3553210..3554673) /gene="iolA" /locus_tag="BSU_39760" /old_locus_tag="BSU39760" /EC_number="1.2.1.27" /EC_number="1.2.1.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658656, 11566986, 16332250, 18310071, 20971862, 22720735, 26832667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 11566986, 16332250, 18310071, 20971862, 22720735, 26832667; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylmalonate-semialdehyde dehydrogenase" /protein_id="NP_391855.1" /db_xref="EnsemblGenomes-Gn:BSU39760" /db_xref="EnsemblGenomes-Tr:CAB16012" /db_xref="GOA:P42412" /db_xref="InterPro:IPR010061" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR023510" /db_xref="PDB:1T90" /db_xref="SubtiList:BG11117" /db_xref="UniProtKB/Swiss-Prot:P42412" /translation="MAEIRKLKNYINGEWVESKTDQYEDVVNPATKEVLCQVPISTKE DIDYAAQTAAEAFKTWSKVAVPRRARILFNFQQLLSQHKEELAHLITIENGKNTKEAL GEVGRGIENVEFAAGAPSLMMGDSLASIATDVEAANYRYPIGVVGGIAPFNFPMMVPC WMFPMAIALGNTFILKPSERTPLLTEKLVELFEKAGLPKGVFNVVYGAHDVVNGILEH PEIKAISFVGSKPVGEYVYKKGSENLKRVQSLTGAKNHTIVLNDANLEDTVTNIVGAA FGSAGERCMACAVVTVEEGIADEFMAKLQEKVADIKIGNGLDDGVFLGPVIREDNKKR TLSYIEKGLEEGARLVCDGRENVSDDGYFVGPTIFDNVTTEMTIWKDEIFAPVLSVIR VKNLKEAIEIANKSEFANGACLFTSNSNAIRYFRENIDAGMLGINLGVPAPMAFFPFS GWKSSFFGTLHANGKDSVDFYTRKKVVTARYPAPDFN*" /label="iolA CDS" gene complement(3553210..3554673) /gene="iolA" /locus_tag="BSU_39760" /old_locus_tag="BSU39760" /label="iolA gene" S_feature complement(3554674..3554878) /Source="Nicolas_S_feature" /locus_tag="new_4084384_4084588_c" /HighExp="M0t90, M40t90, Lbtran, BI, Mt0, T0.30H, BC, S1, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1526" promotor_-35 3554677..3554684 /Source="Nicolas_upshift_promotors" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="promotor_-35" promotor_-10 3554700..3554719 /Source="Nicolas_upshift_promotors" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="promotor_-10" upshifts 3554707 /Source="Nicolas_upshifts" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="upshifts" S_feature 3554714..3555020 /Source="Nicolas_S_feature" /locus_tag="new_4084424_4084730" /HighExp="G180, Paraq, G150, Oxctl, H2O2, G135, Diami, LBGexp, dia5, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.788" /TUlongSig="NA" /TUlongPSig="NA" /label="S1527" promotor_-10 complement(3554860..3554879) /Source="Nicolas_upshift_promotors" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3554878) /Source="Nicolas_upshifts" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3554880..3555032) /Source="Nicolas_S_feature" /locus_tag="new_4084590_4084742_c" /HighExp="M40t90, M0t90, Lbtran, Diami, Heat, dia5, C30, BI, S1, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1528" promotor_-35 complement(3554894..3554901) /Source="Nicolas_upshift_promotors" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3554980..3554987 /Source="Nicolas_upshift_promotors" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="promotor_-35" promotor_-10 3555002..3555021 /Source="Nicolas_upshift_promotors" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="promotor_-10" upshifts 3555022 /Source="Nicolas_upshifts" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="upshifts" promotor_-10 complement(3555033..3555052) /Source="Nicolas_upshift_promotors" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="promotor_-10" upshifts complement(3555049) /Source="Nicolas_upshifts" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="upshifts" promotor_-35 complement(3555068..3555075) /Source="Nicolas_upshift_promotors" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="promotor_-35" CDS 3555089..3555844 /gene="iolR" /locus_tag="BSU_39770" /old_locus_tag="BSU39770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 11807058, 18310071, 24878601, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 11807058, 18310071, 24878601, 26735940; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the iol operon (DeoR family)" /protein_id="NP_391856.1" /db_xref="EnsemblGenomes-Gn:BSU39770" /db_xref="EnsemblGenomes-Tr:CAB16013" /db_xref="GOA:P46337" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11364" /db_xref="UniProtKB/Swiss-Prot:P46337" /translation="MKLMRIQEMEEYILSHGTVSLDELCQVFNVSKNTVRRDINKLTE KGAIEKVYGGVTSIEKTALVPFENRTIQHQDEKTKIAHYASRFIEDHDLVFIDSGTTT KSILDTLDPAKNVTILTNSLDIINAASALKNINLIIIGNNYKRKTRSFVGMDDPAMLD KYNINKAFMSATGTTLTHGLTNSDLLEYEIKKRISEKAKEVYLLADHSKFGKSTLLTY APFDRLHCIVTSQPLDDEYTQYCNEHQIGIHLA*" /label="iolR CDS" gene 3555089..3555844 /gene="iolR" /locus_tag="BSU_39770" /old_locus_tag="BSU39770" /label="iolR gene" promotor_-35 3555823..3555829 /Source="Nicolas_upshift_promotors" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3555844..3555863 /Source="Nicolas_upshift_promotors" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3555858 /Source="Nicolas_upshifts" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="upshifts" CDS 3555898..3556830 /gene="iolS" /locus_tag="BSU_39780" /old_locus_tag="BSU39780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9226270, 15019785, 22720735, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_391857.1" /db_xref="EnsemblGenomes-Gn:BSU39780" /db_xref="EnsemblGenomes-Tr:CAB16014" /db_xref="GOA:P46336" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PYF" /db_xref="PDB:1PZ0" /db_xref="SubtiList:BG11363" /db_xref="UniProtKB/Swiss-Prot:P46336" /translation="MKKAKLGKSDLQVFPIGLGTNAVGGHNLYPNLNEETGKELVREA IRNGVTMLDTAYIYGIGRSEELIGEVLREFNREDVVIATKAAHRKQGNDFVFDNSPDF LKKSVDESLKRLNTDYIDLFYIHFPDEHTPKDEAVNALNEMKKAGKIRSIGVSNFSLE QLKEANKDGLVDVLQGEYNLLNREAEKTFFPYTKEHNISFIPYFPLVSGLLAGKYTED TTFPEGDLRNEQEHFKGERFKENIRKVNKLAPIAEKHNVDIPHIVLAWYLARPEIDIL IPGAKRADQLIDNIKTADVTLSQEDISFIDKLFA*" /label="iolS CDS" gene 3555898..3556830 /gene="iolS" /locus_tag="BSU_39780" /old_locus_tag="BSU39780" /label="iolS gene" downshifts 3556832 /Source="Nicolas_upshifts" /id="D2054" /incds=0 /nref=154 /ntot=259 /MaxReadThrough="4.521" /MaxDrop="7.17874" /score="39.70215" /energy="-17.1" /TU="U3129" /idTUdmin="U3127" /TUdmin=6 /isTUend="TRUE" /label="downshifts" promotor_-35 3556909..3556916 /Source="Nicolas_upshift_promotors" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3556930..3556949 /Source="Nicolas_upshift_promotors" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3556936..3557091 /Source="Nicolas_S_feature" /locus_tag="new_4086646_4086801" /HighExp="dia5, LPhT, Diami, Etha, dia15, LBGstat, M9-stat, Lbtran, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.835, 0.994" /TUlongSig="SigA" /TUlongPSig="0.99" /label="S1529" upshifts 3556936 /Source="Nicolas_upshifts" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="upshifts" CDS 3557092..3557742 /gene="yxcE" /locus_tag="BSU_39790" /old_locus_tag="BSU39790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391858.1" /db_xref="EnsemblGenomes-Gn:BSU39790" /db_xref="EnsemblGenomes-Tr:CAB16015" /db_xref="GOA:P46335" /db_xref="SubtiList:BG11362" /db_xref="UniProtKB/Swiss-Prot:P46335" /translation="MKLKYVKALVAVTVALGVLLPSTISHAKSFSGRSSSSYSSRSSS SSYSGSYKSSPKSSYSSGSSSSSKKSKTSDDSSSSISLKKKPSEKASSSSSKKSSGTF SGATSKVTGKTYSGKTSKAYVGGRYVSVNHYYHAGFAPSGWFGYYSGFTMGMFMISMM HPWGYTYHPVGGPGYVSYGASPIAWIVDIIALIIILIIVIALIRAFKAPKTYRRRF*" /label="yxcE CDS" gene 3557092..3557742 /gene="yxcE" /locus_tag="BSU_39790" /old_locus_tag="BSU39790" /label="yxcE gene" CDS 3557746..3558054 /gene="yxcD" /locus_tag="BSU_39800" /old_locus_tag="BSU39800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391859.1" /db_xref="EnsemblGenomes-Gn:BSU39800" /db_xref="EnsemblGenomes-Tr:CAB16016" /db_xref="InterPro:IPR020516" /db_xref="SubtiList:BG11361" /db_xref="UniProtKB/Swiss-Prot:P46334" /translation="MRLILNEQEIVDGICVYISNEEDIYPEDVEVKELSYNKRTGFFA EATFGLHHKQLMSDDISEGIIQFLEEYHNFNPDVTVVELQFDKKKGFSALVFVNEAEE *" /label="yxcD CDS" gene 3557746..3558054 /gene="yxcD" /locus_tag="BSU_39800" /old_locus_tag="BSU39800" /label="yxcD gene" downshifts 3558056 /Source="Nicolas_upshifts" /id="D2055" /incds=0 /nref=185 /ntot=262 /MaxReadThrough="1.91541" /MaxDrop="6.4314" /score="14.1581732" /energy="-8.8" /TU="NA" /idTUdmin="U3130" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 3558198..3558204 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3558220..3558238 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3558230 /Source="Nicolas_upshifts" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="upshifts" CDS 3558292..3559677 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391860.1" /db_xref="EnsemblGenomes-Gn:BSU39810" /db_xref="EnsemblGenomes-Tr:CAB16017" /db_xref="GOA:P46333" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11360" /db_xref="UniProtKB/Swiss-Prot:P46333" /translation="MKKDTRKYMIYFFGALGGLLYGYDTGVISGALLFINNDIPLTTL TEGLVVSMLLLGAIFGSALSGTCSDRWGRRKVVFVLSIIFIIGALACAFSQTIGMLIA SRVILGLAVGGSTALVPVYLSEMAPTKIRGTLGTMNNLMIVTGILLAYIVNYLFTPFE AWRWMVGLAAVPAVLLLIGIAFMPESPRWLVKRGSEEEARRIMNITHDPKDIEMELAE MKQGEAEKKETTLGVLKAKWIRPMLLIGVGLAIFQQAVGINTVIYYAPTIFTKAGLGT SASALGTMGIGILNVIMCITAMILIDRVGRKKLLIWGSVGITLSLAALSGVLLTLGLS ASTAWMTVVFLGVYIVFYQATWGPVVWVLMPELFPSKARGAATGFTTLVLSAANLIVS LVFPLMLSAMGIAWVFMVFSVICLLSFFFAFYMVPETKGKSLEEIEASLKKRFKKKKS TQNQVLNERTL*" /label="csbC CDS" gene 3558292..3559677 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /label="csbC gene" downshifts 3559663 /Source="Nicolas_upshifts" /id="D2056" /incds=0 /nref=69 /ntot=115 /MaxReadThrough="4.59405" /MaxDrop="7.32264" /score="22.9943012" /energy="-16.4" /TU="NA" /idTUdmin="U3131" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 3559708..3560258 /Source="Nicolas_S_feature" /locus_tag="new_4089418_4089968" /HighExp="Etha, C30, C90, Gly, Sw, G135, Fru, HiTm, M/G, Mal" /AntisenseName="htpG" /AntisenseCor="7.4766600377621104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1530" CDS complement(3559719..3561599) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III heat-shock protein (ATP-dependent molecular chaperone HSP90)" /protein_id="NP_391861.1" /db_xref="EnsemblGenomes-Gn:BSU39820" /db_xref="EnsemblGenomes-Tr:CAB16018" /db_xref="GOA:P46208" /db_xref="InterPro:IPR001404" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR019805" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020575" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037196" /db_xref="SubtiList:BG11359" /db_xref="UniProtKB/Swiss-Prot:P46208" /translation="MAKKEFKAESKRLLDMMINSIYTQKEIFLRELISNSSDAIDKIY YKALTDDALTFDKDSYYIKVAADKDARTLTISDTGIGMTKDELEQHLGTIAKSGSLAF KKENELKDGHDIIGQFGVGFYAAFMVADVVTVISKALGSEEAYKWESAGADGYTIEPC EKDSVGTDIILKIKENTEDDSYDEFLEEYRLKAIIKKYSDFIRYPIKMDTTINKPKEG SENEFEEVQEEQTVNSMVPIWRKNKSELTDEDYEKFYAEKHYGFDKPLTHVHISVDGA VRYNAILFVPENMPFDYYSKEYEKGLELYSNGVLIMNKCADLLPDHFSFVKGMVDSED LSLNISREMLQHDRQLKLIAKNISKKIKSELQSLLKKDREKYETFYKSFGRQLKFGVY NDFGANKDQLKDLLLFYSSKEKKLVSLDEYVSRMPEEQKFIYYATGDSYDRIEKLPQT EMVADKGYEILYFTEDIDEFAIKMLASYQEKEFKSVSSGDLGIDTDEDQKQSEEEESK YKDLFEEMKNILSDKVKNVRISKRLKSHPVCLAADGEVTIEMEKILNAMPDSQNVKAE KVLEINPNHEVFQTLQDAFEQDKEKLSLYTNLLYNQALLIEGLPIQDPVEFTNNICKV MV*" /label="htpG CDS" gene complement(3559719..3561599) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /label="htpG gene" downshifts complement(3559725) /Source="Nicolas_upshifts" /id="D2057" /incds=0 /nref=169 /ntot=288 /MaxReadThrough="0.81611" /MaxDrop="6.49379" /score="34.0973015" /energy="-16.4" /TU="NA" /idTUdmin="U3132" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" S_feature complement(3561600..3561697) /Source="Nicolas_S_feature" /locus_tag="new_4091310_4091407_c" /HighExp="Lbtran, S1, LBGtran, C90, M40t45, M9-tran, GM 150, dia0, T-2.40H, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="SigA" /TUlongPSig="0.995" /label="S1531" promotor_-10 complement(3561688..3561707) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3561697) /Source="Nicolas_upshifts" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3561722..3561729) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3561767..3562018) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391862.1" /db_xref="EnsemblGenomes-Gn:BSU39830" /db_xref="EnsemblGenomes-Tr:CAB16019" /db_xref="GOA:P46332" /db_xref="SubtiList:BG11358" /db_xref="UniProtKB/Swiss-Prot:P46332" /translation="MKVQHKKELKFYCIVTIPSAFVVLTVISFLLQEITFPVTASAFL NASWHNLLFLIPFGLFFYPVHIWMKREFGRWNDTEKKRG*" /label="yxcA CDS" gene complement(3561767..3562018) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /label="yxcA gene" downshifts complement(3561785) /Source="Nicolas_upshifts" /id="D2058" /incds=0 /nref=11 /ntot=62 /MaxReadThrough="3.50049" /MaxDrop="5.56962" /score="-3.89567108" /energy="-6.7" /TU="U3133" /idTUdmin="U3133" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" misc_feature complement(3562040..3562059) /Source="Nicolas_upshift_promotors" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3562049) /Source="Nicolas_upshifts" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="upshifts" promotor_-35 3562082..3562088 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3562102..3562120 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3562103 /Source="Nicolas_upshifts" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="upshifts" CDS 3562135..3562956 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391863.2" /db_xref="EnsemblGenomes-Gn:BSU39840" /db_xref="EnsemblGenomes-Tr:CAB16020" /db_xref="GOA:P46331" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11357" /db_xref="UniProtKB/Swiss-Prot:P46331" /translation="MGRLENKTAVITGAATGIGQATAEVFANEGARVIIGDINKDQME ETVDAIRKNGGQAESFHLDVSDENSVKAFADQIKDACGTIDILFNNAGVDQEGGKVHE YPVDLFDRIIAVDLRGTFLCSKYLIPLMLENGGSIINTSSMSGRAADLDRSGYNAAKG GITNLTKAMAIDYARNGIRVNSISPGTIETPLIDKLAGTKEQEMGEQFREANKWITPL GRLGQPKEMATVALFLASDDSSYVTGEDITADGGIMAYTWPGKMLIEEKWKEETK*" /label="yxbG CDS" gene 3562135..3562956 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /label="yxbG gene" downshifts 3562940 /Source="Nicolas_upshifts" /id="D2059" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="2.87575" /MaxDrop="5.67438" /score="22.9485028" /energy="-10.5" /TU="U3134" /idTUdmin="U3134" /TUdmin="-221" /isTUend="FALSE" /label="downshifts" CDS complement(3562985..3564127) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11160890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391864.1" /db_xref="EnsemblGenomes-Gn:BSU39850" /db_xref="EnsemblGenomes-Tr:CAB16021" /db_xref="GOA:P46330" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG11356" /db_xref="UniProtKB/Swiss-Prot:P46330" /translation="MPESAEAQVKEALLALLKDRDIQHITMKEIAEKAKVSRGSLYLY YEDKFSIIEDVIEDMKEGLGKALFDAFSHMDTLHLNKKRQTVHPTLSFVHEHRSFFSV MMNRGHFHRFFKDVFQQDVLLAPIHVNLTPIERDIYGHYRALYTYAIILYWLNEDAAA SPEAISQKVWELVSQKRFYWLFGKAVPGEREKEKQIDRRVVRTREALQKAFLDVLAEK QDYAGITISDITRKSNIRRATFYDHYANKEELLQTMIQRSCAEIIDHLTIASSPNEFS LKEAEKALAILLSALSNMPIVHFLNREWGVPHVIPDMFKALESFYLHQQTDIHAEKKL YAHYVSAMIIGLLLYRLDEGKAHPPEVLAREFLQFLDVKKYKVVLL*" /label="yxbF CDS" gene complement(3562985..3564127) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /label="yxbF gene" downshifts complement(3562995) /Source="Nicolas_upshifts" /id="D2060" /incds=0 /nref=10 /ntot=163 /MaxReadThrough="1.63217" /MaxDrop="3.79969" /score="-0.564494299" /energy="-10.5" /TU="NA" /idTUdmin="U3135" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3564128..3564227) /Source="Nicolas_S_feature" /locus_tag="new_4093838_4093937_c" /HighExp="H2O2, Diami, dia15, Paraq, G180, G135, G150, dia5, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1532" promotor_-10 complement(3564215..3564234) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3564226) /Source="Nicolas_upshifts" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3564248..3564255) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3564270..3565607 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /EC_number="1.2.1.3" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391865.2" /db_xref="EnsemblGenomes-Gn:BSU39860" /db_xref="EnsemblGenomes-Tr:CAB16022" /db_xref="GOA:P46329" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11355" /db_xref="UniProtKB/Swiss-Prot:P46329" /translation="MEQQVKDDIQRVFQLQKKQQKALRASTAEQRREKLQRFLDSVIA HEEEIIEAIRKDVRKPYHEVKKAEIEGTKKAIRDNMNNLEQWMAPKEVGSSLSPDANG ILMYEPKGVTLILGPWNYPFMLTMAPLAASLAAGNSAIVKLSDFTMNTSNIAAKVIRD AFDEKEVAIFEGEVEVATELLDQPFDHIFFTGSTNVGKIVMTAAAKHLASVTLELGGK SPTIIDSEYDLMDAAKKIAVGKFVNAGQTCIAPDYLFIKKDVQDRFAGILQTVVNAGF MEDDHTPDRSKFTQIVNDRNFNRVKDLFDDAIERGAEVVFGGVFDASDRTISPTVLKN VTPDMKIMQEEIFASILPMMNYEDIDEVIDYVNDRDKPLALYVFSKNQDLIDNVLQHT TSGNAAINDVVVHFSDVNLPFGGVNTSGIGSYHGVYGFKEFSHEKGVFIQAAE*" /label="aldX CDS" gene 3564270..3565607 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /label="aldX gene" S_feature complement(3565012..3565612) /Source="Nicolas_S_feature" /locus_tag="new_4094722_4095322_c" /HighExp="T1.30H, T2.30H, T2.0H, T1.0H, T-2.40H, T3.0H, T3.30H, T0.0H, T-0.40H, T-3.40H" /AntisenseName="aldX" /AntisenseCor="-0.39894728806999702" /AntisenseRegPval="-11" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1533" CDS complement(3565646..3566125) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391866.2" /db_xref="EnsemblGenomes-Gn:BSU39870" /db_xref="EnsemblGenomes-Tr:CAB16023" /db_xref="GOA:P46328" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11354" /db_xref="UniProtKB/Swiss-Prot:P46328" /translation="MNIIPTCQVPKDLVSAFFQKHWGSPQMVISSGIYNCDELDGYGM LNDDNQIVGLITYIFEEDACEIISLDSVIENKGIGTALLEKAEEACRERNIKQIKLIT TNDNIHALAFYQKRGYRLDRLFVNAVETARKMKPEIPLLADNKIPIRDELLLVKELQ* " /label="yxbD CDS" gene complement(3565646..3566125) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /label="yxbD gene" downshifts complement(3565657) /Source="Nicolas_upshifts" /id="D2061" /incds=0 /nref=1 /ntot=39 /MaxReadThrough="3.82941" /MaxDrop="2.52984" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" CDS complement(3566205..3567197) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391867.1" /db_xref="EnsemblGenomes-Gn:BSU39880" /db_xref="EnsemblGenomes-Tr:CAB16024" /db_xref="GOA:P46327" /db_xref="InterPro:IPR003347" /db_xref="PDB:1VRB" /db_xref="SubtiList:BG11353" /db_xref="UniProtKB/Swiss-Prot:P46327" /translation="MSAVTESVLESIISPVTMSEFLEEYWPVKPLVARGEVERFTSIP GFEKVRTLENVLAIYNNPVMVVGDAVIEESEGITDRFLVSPAEALEWYEKGAALEFDF TDLFIPQVRRWIEKLKAELRLPAGTSSKAIVYAAKNGGGFKAHFDAYTNLIFQIQGEK TWKLAKNENVSNPMQHYDLSEAPYYPDDLQSYWKGDPPKEDLPDAEIVNLTPGTMLYL PRGLWHSTKSDQATLALNITFGQPAWLDLMLAALRKKLISDNRFRELAVNHQSLHESS KSELNGYLESLIQTLSENAETLTPEQIFQSQDSDFDPYQSTQLVFRQLLTSYKF*" /label="yxbC CDS" gene complement(3566205..3567197) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /label="yxbC gene" downshifts complement(3566229) /Source="Nicolas_upshifts" /id="D2062" /incds=0 /nref=5 /ntot=98 /MaxReadThrough="5.86537" /MaxDrop="5.28716" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-1188" /isTUend="FALSE" /label="downshifts" downshifts 3567187 /Source="Nicolas_upshifts" /id="D2063" /incds=0 /nref=2 /ntot=56 /MaxReadThrough="1.15059" /MaxDrop="3.74519" /score="9.93493822" /energy="-12.4" /TU="NA" /idTUdmin="U3134" /TUdmin=4026 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3567220..3567239) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3567238) /Source="Nicolas_upshifts" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3567254..3567261) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3567260..3567267 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3567281..3567705 /Source="Nicolas_S_feature" /locus_tag="new_4096991_4097415" /HighExp="T2.0H, T5.0H, M9-stat, T3.0H, T1.30H, T1.0H, T3.30H, T2.30H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998942" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1534" upshifts 3567281 /Source="Nicolas_upshifts" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3567282..3567301 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 3567287..3567699 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /product="putative small RNA or mRNA leader sequence" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="srlX RNA" gene 3567287..3567699 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /label="srlX gene" upshifts complement(3567307) /Source="Nicolas_upshifts" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3567317..3567331) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3567339..3567343) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3567671 /Source="Nicolas_upshifts" /id="D2064" /incds=0 /nref=2 /ntot=9 /MaxReadThrough="8.39077" /MaxDrop="5.02548" /score="9.93493822" /energy="-12.4" /TU="U3137" /idTUdmin="U3134" /TUdmin=4510 /isTUend="FALSE" /label="downshifts" CDS 3567706..3568440 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /EC_number="2.1.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941984, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_391868.1" /db_xref="EnsemblGenomes-Gn:BSU39890" /db_xref="EnsemblGenomes-Tr:CAB16025" /db_xref="GOA:P46326" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11352" /db_xref="UniProtKB/Swiss-Prot:P46326" /translation="MITAEECRTYKEFVDLYQSYLYPLLGARLSRMYSPKNKVIIDMG TGPGYLSIQLAKRTNAHVHAVDINPAMHEIAQEEAKKSGVSSLISFDLEDVHHLSYAD QYADFIVSYSCLHHWEDVVKGLKECYRVLAPGGKIVILDTFNPQGSHLEIMRKQIKEP EYFRFVREAFEESYSFEDIHQFVQDAGIPNYSLETFHFLPEDFIESLDELEDAPLWEQ NDQSTDHEIESVTWMLTIEKEKEGAL*" /label="yxbB CDS" gene 3567706..3568440 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /label="yxbB gene" CDS 3568440..3568709 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17083466" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391869.1" /db_xref="EnsemblGenomes-Gn:BSU39900" /db_xref="EnsemblGenomes-Tr:CAB16026" /db_xref="InterPro:IPR008792" /db_xref="SubtiList:BG11351" /db_xref="UniProtKB/Swiss-Prot:P46325" /translation="MINESTVLSKNPEMPSRKYLKSIIIEPGITLNEMASDIYNHIDG KVSIHDICSKIVNEYDVDYQTCLEDCMELFELLIDHEAIKVKQGA*" /label="yxbA CDS" gene 3568440..3568709 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /label="yxbA gene" CDS 3568713..3569195 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20185509" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391870.1" /db_xref="EnsemblGenomes-Gn:BSU39910" /db_xref="EnsemblGenomes-Tr:CAB16027" /db_xref="SubtiList:BG14166" /db_xref="UniProtKB/Swiss-Prot:O34704" /translation="MEKQKVLALPDDVHELSTHRSKSIVNYIITLLAFAKKQGLTHQD IVSWIHEQYEERGYYDEWRHINSQQPVGSFVELFIKGRRLLYDKIELFETEDKYVVNT HTWYEKEPSEAFFYFEIDPEEFSAYASILAIENAKRLGIKIDIVKETDVETAYIYKHQ *" /label="yxnB CDS" gene 3568713..3569195 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /label="yxnB gene" CDS 3569216..3571459 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /EC_number="6.3.5.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 17083466, 20185509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 17083466, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (glutamine-hydrolyzing)" /protein_id="NP_391871.2" /db_xref="EnsemblGenomes-Gn:BSU39920" /db_xref="EnsemblGenomes-Tr:CAB16028" /db_xref="GOA:P42113" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11116" /db_xref="UniProtKB/Swiss-Prot:P42113" /translation="MCGLAGIINLAAPRSQECTFHILKGMADAISYRGPDDEQYHIDS KVGFAFRRLSILDLVNGQQPFLNEDGSIVVMVNGEIYNYKELKASLHNHMFKTTSDCE VIVHLYEEKGIGFVDDIIGMFSIAIWDKNKNKVFLVRDRFGIKPLFYTELKHELIFAS EIKSLFSHPHCPRQFNWKEALSDIWLSGEAASNHKETTSFFVNIQNLDAGHYLEINLT TNERKTASYWSLQDILLRQGYRENLHPDDLIEGYRELLADSVHRCLQSDVEVGLFLSG GIDSAAVAHFAAEKQDLHTFTVLSQSTFTNEDAKYAHWLAKDLHLPNHQVLYQLGNDE LLQPESYKHLLWICETPFCGPEQLYKFHLHKYAKAIRPNLKVMLTGQGSDEFNGGYST TLSPAENPSWEGFIESVNTMEMNRLHRLQGNIFRVWEEHFGLSPINLSYLKSNDSSQA DPWQSYVLTKYRDLQMYNCWHEDRIAAANHIENRVPFLDHRLVEWVCGIPDGLRKDLL WDKSVLRKSLTNELHTSYTHRPKVPFFYGKDVRYTHKMMFHLLKKNNYQLIEEAFSHS DASSIIQVEHIHAIMTYLEDDPEFTNFEFLLRLVNMGLLSKMTKETPSVQLDITSHLE SITIKDWHSQEGDIASRLNISANKCEGQDILALNPGVTLLRPESDSEHCIYIAEEGFI QFIVSEEDVGAWLHILCDINGKDTLHTILDRHGVSLEEVAKYIQEAIEHNIILIKQKN LPEGAYR*" /label="asnH CDS" gene 3569216..3571459 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /label="asnH gene" CDS 3571456..3572655 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989, 15849754, 16850406, 20185509; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391872.2" /db_xref="EnsemblGenomes-Gn:BSU39930" /db_xref="EnsemblGenomes-Tr:CAB16029" /db_xref="GOA:P42112" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11115" /db_xref="UniProtKB/Swiss-Prot:P42112" /translation="MSIFYSFSALRGLAMGIFSPIWILYLISKDYDFLQIGLMGAVLE IAKLIFEVPSGVFADRYGIKISIASSFFFSILTWAFFPFIDSAAICILAMIIWALSDS LISGSFETWMSRVAGEDRFGKEMMKNTQLLITFLIIGSIASGYLYSLNIYFPFLLVMV IYLLLFIWMSVFIKVPSVSETNHGDQNQHDSIKIIKESLKIIFNKKRVLLIVIAGFFT ATAYDTISRYWQPFLSDLGFSEKSLGYIFALGGFTALVLLTLTIRFEKKIEKNPYLAL TSLDSMGMVMTFLLSRAFRPLGIPCTAFLLAIEDIHHPIVTSYLNKFFPDSYKNTLFS LNSGVGAIGEILSGVIFGIISAAFGLSAMFVVVAVFLLIPIILYTIVPKIKDNDMKVQ IEKSQQV*" /label="yxaM CDS" gene 3571456..3572655 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /label="yxaM gene" promotor_-10 complement(3572411..3572429) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3572433) /Source="Nicolas_upshifts" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3572444..3572450) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3572646 /Source="Nicolas_upshifts" /id="D2065" /incds=0 /nref=71 /ntot=174 /MaxReadThrough="3.22879" /MaxDrop="5.42242" /score="-6.94914943" /energy="-8.5" /TU="U3137" /idTUdmin="U3137" /TUdmin="-85" /isTUend="FALSE" /label="downshifts" downshifts complement(3572719) /Source="Nicolas_upshifts" /id="D2066" /incds=0 /nref=156 /ntot=227 /MaxReadThrough="3.53794" /MaxDrop="6.77896" /score="7.32872401" /energy="-16.9" /TU="U3140" /idTUdmin="U3141" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3572719..3573951) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 15743949, 17060472, 18165306, 22720735, 26060272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane associated protein kinase with beta-propeller domain" /protein_id="NP_391873.2" /db_xref="EnsemblGenomes-Gn:BSU39940" /db_xref="EnsemblGenomes-Tr:CAB16030" /db_xref="GOA:P42111" /db_xref="InterPro:IPR002372" /db_xref="InterPro:IPR011047" /db_xref="InterPro:IPR018391" /db_xref="SubtiList:BG11114" /db_xref="UniProtKB/Swiss-Prot:P42111" /translation="MVKSFRMKALIAGAAVAAAVSAGAVSDVPAAKVLQPTAAYAAET VFSQNNGASGFLPGRYDVQAMAPAMFNWSRESRFAGNTDGTLKWQNDIRTTPQNGAGA VIDGDGTVYLHSRDGEMKAFNPDGSVKWVTGNLGKTYTQSPVLGTNGVIYLASYDKKI YFIDKETGEILTTVPLSGGPSSETVIGSDGTLYFSTLDNYVHAIKPTSKSTWTERWKL KTNGVVSSVPVLAKNGTVYVGTYNYVFYAINSGTGQVKWSRTTSNAFKGYPVIDKDGN IYAGNQDGQLYAYTSTGSLKWTFPLNGFSSSSPAIDHNGNIYIGSGSGELFSISKNGD MNWSFYTDGPVRTAPLIDAKGTVYFGSDDMKVYAADANGNELWSYQTDSNVVSSPQLA EDGTLYIGSYTKLMAFGK*" /label="yxaL CDS" gene complement(3572719..3573951) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /label="yxaL gene" promotor_-10 complement(3573983..3574002) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3573995) /Source="Nicolas_upshifts" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3574016..3574021) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3574052..3574477) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15743949, 15849754, 16850406, 27902860; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391875.2" /db_xref="EnsemblGenomes-Gn:BSU39950" /db_xref="EnsemblGenomes-Tr:CAB16032" /db_xref="GOA:P42109" /db_xref="InterPro:IPR020204" /db_xref="SubtiList:BG11112" /db_xref="UniProtKB/Swiss-Prot:P42109" /translation="MSKKNSVAIMTTISAFLFCAVIVAASLSPLAGTGAAANQFNSAG MWSAVGMILVLYFIPFLVYMLGVDAMRYVMAVLCGFGLLIHLSSAGFILMFSFFSDHL LSEVIFVLGVSLAAAAVNVIWFVAAFRSGAEKTSVNTLT*" /label="yxaJ CDS" gene complement(3574052..3574477) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /label="yxaJ gene" promotor_-10 complement(3574505..3574524) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3574519) /Source="Nicolas_upshifts" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3574537..3574543) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3574669..3574676 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3574686 /Source="Nicolas_upshifts" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3574691..3574710 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3574734..3575189 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391876.1" /db_xref="EnsemblGenomes-Gn:BSU39960" /db_xref="EnsemblGenomes-Tr:CAB16033" /db_xref="GOA:P42108" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11111" /db_xref="UniProtKB/Swiss-Prot:P42108" /translation="MEKPAGFWIRFLAYFIDGIIVSVPSYIILFIINSVFVAGAVATN PYMTEEEYLVKYMTLAFLPTMLIMIVISVLYYGLLTASKMQGTLGKKILGLKVVNEQG ERVSVGQGIGRYFAYILSGIIFYIGFIMIAFGEKKGLHDIICKTRVVYK*" /label="yxaI CDS" gene 3574734..3575189 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /label="yxaI gene" downshifts 3575127 /Source="Nicolas_upshifts" /id="D2067" /incds=1 /nref=58 /ntot=234 /MaxReadThrough="3.24719" /MaxDrop="5.4441" /score="18.1083522" /energy="-13.4" /TU="U3142" /idTUdmin="U3142" /TUdmin="-637" /isTUend="FALSE" /label="downshifts" S_feature 3575190..3575803 /Source="Nicolas_S_feature" /locus_tag="new_4104900_4105513" /HighExp="LPh, HPh, MG 60, BMM, MG t5, G180, MG 45, G150, MG-0.2, MG 10" /AntisenseName="yxaH" /AntisenseCor="0.37646026982403002" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1535" CDS complement(3575219..3576427) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein involved in response to flavonoids" /protein_id="NP_391877.2" /db_xref="EnsemblGenomes-Gn:BSU39970" /db_xref="EnsemblGenomes-Tr:CAB16034" /db_xref="GOA:P42107" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11110" /db_xref="UniProtKB/Swiss-Prot:P42107" /translation="MSSLQPTLTNERIGVLDVLRGMAIFGILFVNLAHFSYPDMYLSM LGKENFFMDKWSEADFAAADILKFFIQTKCILLFSFLFGFGMVVMMERAENKGKRFVP LYVRRLMALLLFGTIHAFLIWDGDILTEYALLGFVLLLFRKAKPKTLLIWAVSLYLLF SIPFMLTSFDQSNGQEWVQAVTQQAKQAIHVYGSGSLKDIAEQRIHDRLVYMSSNGML TYNPLNYFFASIPYFSMFLLGAAAAKSRYLHEPEKHRKGLKRLWMAGLVIGIGAQVLY SVTDKEICLLIGAPFLMFFYVTTVVYLYHKTRVRTVLQSFSAVGRMAFTNYLMQSIVC TWIFYHYGLGLYGKVYPAAGVLITIAVCAVQMVFSHLWLRVFRMGPFEWLWRSATYLS WQPIAKKTKV*" /label="yxaH CDS" gene complement(3575219..3576427) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /label="yxaH gene" downshifts complement(3575246) /Source="Nicolas_upshifts" /id="D2068" /incds=0 /nref=14 /ntot=66 /MaxReadThrough="0.30987" /MaxDrop="3.782" /score="34.1593124" /energy="-16.2" /TU="NA" /idTUdmin="U3143" /TUdmin=286 /isTUend="FALSE" /label="downshifts" S_feature complement(3576428..3576534) /Source="Nicolas_S_feature" /locus_tag="new_4106138_4106244_c" /HighExp="T-5.40H, T-4.40H, SMMPr, T-2.40H, T-3.40H, T-1.40H, Sw, T0.0H, Pyr, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1536" CDS complement(3576535..3577548) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /EC_number="1.13.11.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quercetin dioxygenase" /protein_id="NP_391878.2" /db_xref="EnsemblGenomes-Gn:BSU39980" /db_xref="EnsemblGenomes-Tr:CAB16035" /db_xref="GOA:P42106" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="PDB:1Y3T" /db_xref="PDB:2H0V" /db_xref="SubtiList:BG11109" /db_xref="UniProtKB/Swiss-Prot:P42106" /translation="MKTLCTHSLPKEKMPYLLRSGEGERYLFGRQVATVMANGRSTGD LFEIVLLSGGKGDAFPLHVHKDTHEGILVLDGKLELTLDGERYLLISGDYANIPAGTP HSYRMQSHRTRLVSYTMKGNVAHLYSVIGNPYDHAEHPPYASEEVSNERFAEAAAVAD IVFLDEAKPACSAKLAELTELPDGAVPYVLESGEGDRLLTGDQLHRIVAAQKNTDGQF IVVSSEGPKGDRIVDHYHEYHTETFYCLEGQMTMWTDGQEIQLNPGDFLHVPANTVHS YRLDSHYTKMVGVLVPGLFEPFFRTLGDPYEGHIFPCEPQALRFDRILQNIEALDLKV MKP*" /label="qdoI CDS" gene complement(3576535..3577548) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /label="qdoI gene" S_feature complement(3577549..3577622) /Source="Nicolas_S_feature" /locus_tag="new_4107259_4107332_c" /HighExp="T-3.40H, T-5.40H, T-1.40H, T-2.40H, T-4.40H, T-0.40H, T0.0H, Pyr, SMMPr, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1537" promotor_-10 complement(3577607..3577626) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3577622) /Source="Nicolas_upshifts" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3577639..3577646) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3577642..3578217) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17483215, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483215, 21737930; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of qdoI" /protein_id="NP_391879.2" /db_xref="EnsemblGenomes-Gn:BSU39990" /db_xref="EnsemblGenomes-Tr:CAB16036" /db_xref="GOA:P42105" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1SGM" /db_xref="SubtiList:BG11108" /db_xref="UniProtKB/Swiss-Prot:P42105" /translation="MTSRGDSREKILHTASRLFQLQGYHATGLNQIVKESGAPKGSLY HFFPNGKEELAIEAVTYTGKIVEHLIQQSMDESSDPVEAIQLFIKKTASQFDNTESIK GIPVGLLASETALISEPLRTVCMKVFKSWEAVFARKLMENGFAEEEANQLGTLINSMI EGGIMLSLTNKDKTPLLLIAEQIPVLVRKKG*" /label="qdoR CDS" gene complement(3577642..3578217) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /label="qdoR gene" downshifts complement(3577666) /Source="Nicolas_upshifts" /id="D2069" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="1.66581" /MaxDrop="2.62803" /score="-2.51956315" /energy="-8.8" /TU="NA" /idTUdmin="U3144" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3578246..3578265) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3578260) /Source="Nicolas_upshifts" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3578280..3578287) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3578288..3578294 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3578309..3578327 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3578316 /Source="Nicolas_upshifts" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="upshifts" CDS 3578348..3579418 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391880.2" /db_xref="EnsemblGenomes-Gn:BSU40000" /db_xref="EnsemblGenomes-Tr:CAB16037" /db_xref="GOA:O32291" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14165" /db_xref="UniProtKB/Swiss-Prot:O32291" /translation="MTIDHSVTNTEQLEQQNPAIKTKLKLKKLKDQVIVITGASSGIG LVTARMAAEKGAKVVAAARNEEALKELTDELKEKGHDAIWVKADVGKEEDVNRIAETA ISTFGRFDTWVNNAAVSTFGHAMDVTVEDMKRMFDTNFWGPVYGTRAAVKHYTGRGVP GALINVGSLFGDRGTVIQSTYASAKFALHGWTESIRMELEKEQAPVSVTLIHPGRIDT PYNEHAHSYLDKQPAHYRSMIYPPEAVAEAILFAAEHPKRDMYIGSQAKAIAMLGALF PRLTDRLMEKIMYHSQHAERPSNPREESALYDAGCGMHDRGTNKGWMRSRSYYTKATK RPIVSAAVVAGLVAWAAAKRCR*" /label="yxnA CDS" gene 3578348..3579418 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /label="yxnA gene" downshifts 3579416 /Source="Nicolas_upshifts" /id="D2070" /incds=0 /nref=7 /ntot=44 /MaxReadThrough="2.68466" /MaxDrop="3.96227" /score="-3.48213422" /energy="-11.2" /TU="NA" /idTUdmin="U3145" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3579475..3579906) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391881.1" /db_xref="EnsemblGenomes-Gn:BSU40010" /db_xref="EnsemblGenomes-Tr:CAB16038" /db_xref="GOA:P42103" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11106" /db_xref="UniProtKB/Swiss-Prot:P42103" /translation="MQNQNPVELIEYELTTFIRRAVYLDQSEKRTGNLERSSYLLLRQ LDEFGPARVKELAESFKLDISTLSRQAAALEAKELIYRFSDPSDGRVSLFTITKLGKQ LLKADQQKRLERYEQMLKEWSTQEKEMFGELLQRMNKAFID*" /label="yxaD CDS" gene complement(3579475..3579906) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /label="yxaD gene" promotor_-35 3579936..3579943 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3579957..3579976 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3579966..3580132 /Source="Nicolas_S_feature" /locus_tag="new_4109676_4109842" /HighExp="LBGstat, Cold, Heat, Salt, Etha, H2O2, G180, LBGtran, GM 150, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1538" upshifts 3579966 /Source="Nicolas_upshifts" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3580018..3580037) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3580038) /Source="Nicolas_upshifts" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3580052..3580059) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3580133..3580537 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein involved in export murein hydrolases" /protein_id="YP_003097798.1" /db_xref="EnsemblGenomes-Gn:BSU40021" /db_xref="EnsemblGenomes-Tr:CAX52713" /db_xref="GOA:C0H3T7" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR036640" /db_xref="UniProtKB/Swiss-Prot:C0H3T7" /translation="MKVIRIILQVLILYVFFMIGEAIQHLFHLPVSGSIVGLVLLLIC LGLRIVPVSIIEDGAGFLLSFLPLLFIPAMTGVINYPSLISFNGLMLLITVVLSTIVT IIAAGFASQLLEKKAKKREEKEKCSKHVSRSL*" /label="yxzK CDS" gene 3580133..3580537 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /label="yxzK gene" S_feature complement(3580154..3581206) /Source="Nicolas_S_feature" /locus_tag="new_4109864_4110916_c" /HighExp="Etha, C30, H2O2, Salt, Paraq, GM 120, Diami, Oxctl, G180, Sw" /AntisenseName="yxaC" /AntisenseCor="0.145103505386703" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1539" CDS 3580507..3581199 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative murein hydrolase export regulator" /protein_id="NP_391882.3" /db_xref="EnsemblGenomes-Gn:BSU40022" /db_xref="EnsemblGenomes-Tr:CAB16039" /db_xref="GOA:P42102" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG11105" /db_xref="UniProtKB/Swiss-Prot:P42102" /translation="MQQACIAIIIILLTVAAYLAMVKLYKRFPLPFLIPVLTTTILIV AALMMFHVSYEGYMIGGKWINSLLGPAVVALAYPLYKQWHIIVKHCVPILGGVLVGLC MGMISGLIFAEAFGIDHDLLLSILPKSITTPVAIQIAAGLGGVPSMTVVFVMIAGFSG VILGPLFLKWLRIRSSLGQGIALGSASHALGTSKALEYGELAVSMSSVSMTLCAVLGS FFGPLVVWLFHI*" /label="yxaC CDS" gene 3580507..3581199 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /label="yxaC gene" CDS complement(3581239..3582270) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /EC_number="2.-.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9298659, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exopolysaccharide pyruvyl transferase (biofilm formation)" /protein_id="NP_391883.3" /db_xref="EnsemblGenomes-Gn:BSU40030" /db_xref="EnsemblGenomes-Tr:CAB16040" /db_xref="GOA:P42101" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11104" /db_xref="UniProtKB/Swiss-Prot:P42101" /translation="MTVQEIKGKKLVKGIAPNVEPEALLNDKRKVFLFGSPSYTNIGD QAIAYAEEKFIKNHFPYYEYIEIMDYATDEGIELVKEIIREDDIVCFTGGGNLGNLYL DIEEDRRKVFSAFKDYKSISLPQSVYFEDTEEGQKEKKKTQDAYHQNTNLTIAARETQ TLDVVKETFNSNVIFTPDMVLSLDIVPRELERDGVLFILRADKEKVTDEDFISQMKQW AEKTTYTERTDTVLDTVDTIDYADREKHFMEMLDRIGSSKLVITDRLHAMIFSIITKT PCLVFGNSYGKAKHSYRDWLESLNFIEYTDKNDVEELERMIDRLLQAEPNDVDLSKDF QPLIDFFAS*" /label="yxaB CDS" gene complement(3581239..3582270) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /label="yxaB gene" downshifts complement(3581251) /Source="Nicolas_upshifts" /id="D2071" /incds=0 /nref=5 /ntot=94 /MaxReadThrough="6.52386" /MaxDrop="4.6522" /score="17.8326496" /energy="-15.3" /TU="U3149" /idTUdmin="U3150" /TUdmin=220 /isTUend="FALSE" /label="downshifts" promotor_-35 3582237..3582240 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3582253 /Source="Nicolas_upshifts" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3582257..3582276 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3582307..3582325) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3582325) /Source="Nicolas_upshifts" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3582340..3582346) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3582363..3583511) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /EC_number="2.7.1.31" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15771780, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-glycerate kinase" /protein_id="NP_391884.2" /db_xref="EnsemblGenomes-Gn:BSU40040" /db_xref="EnsemblGenomes-Tr:CAB16041" /db_xref="GOA:P42100" /db_xref="InterPro:IPR004381" /db_xref="InterPro:IPR018193" /db_xref="InterPro:IPR036129" /db_xref="SubtiList:BG11103" /db_xref="UniProtKB/Swiss-Prot:P42100" /translation="MKIIIAPDSFKESLSALEAAEAIERGFKSVFPGADYRKLPVADG GEGTVQSLVDATNGRIIEQVVTGPLGEPVRAFFGMMGDGRTAVIEMAAASGLHLVPVD KRNPLITTTRGTGELIGAALDAGAERLIIGIGGSATNDGGAGMIQALGGRLLDNSGSE IGPGGGALSQLASIDVSGLDSRLRNVKLEVACDVDNPLTGPKGATAVFGPQKGATADM LDVLDQNVSHFADMAEKALGSTFRDTEGAGAAGGLGWSLLTYLQADLKRGIDIVLEAV DFESIVQDADLVITGEGRIDSQTVHGKTPIGVAKAAKSYDVPVIGIAGSISRDSNAVY QHGIDALFSIVPGAVPLEDAFEHAAEYMERTARDIAASIKLAKTMFLI*" /label="glxK CDS" gene complement(3582363..3583511) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /label="glxK gene" promotor_-10 complement(3583550..3583569) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3583561) /Source="Nicolas_upshifts" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3583580..3583587) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3583633..3583640 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3583654..3583673 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3583661 /Source="Nicolas_upshifts" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="upshifts" CDS 3583707..3584438 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7476858, 7642511, 8655507, 9106211, 26151451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7476858, 7642511, 8655507, 9106211, 26151451; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR-gluconate)" /protein_id="NP_391885.1" /db_xref="EnsemblGenomes-Gn:BSU40050" /db_xref="EnsemblGenomes-Tr:CAB16042" /db_xref="GOA:P10585" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10648" /db_xref="UniProtKB/Swiss-Prot:P10585" /translation="MLDSKDLLYPAKWLSKASTGVRVAYELRMRIVSGLIESGTILSE NTIAAEFSVSRSPVREALKILASEKIIRLERMGAVVIGLTEKKIAEIYDVRLLLETFV FERLVKIDIEPLVKDLSKILEMMKVSIKYEDADEFSFQDVLFHETIIRAIDHSYIQMI WNNLKPVMESFILLSMRVRLKEKYEDFTRILDNHELYIQAIKTKDRALMIQSLHQNFD DVQDKVEDLWLSQQMLAKGAEYNND*" /label="gntR CDS" gene 3583707..3584438 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /label="gntR gene" CDS 3584431..3585972 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /EC_number="2.7.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1659648, 2537826, 3020045, 11468405" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1659648, 2537826, 3020045, 11468405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-gluconate kinase" /protein_id="NP_391886.1" /db_xref="EnsemblGenomes-Gn:BSU40060" /db_xref="EnsemblGenomes-Tr:CAB16043" /db_xref="GOA:P12011" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006002" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10649" /db_xref="UniProtKB/Swiss-Prot:P12011" /translation="MTSYMLGIDIGTTSTKAVLFSENGDVVQKESIGYPLYTPDISTA EQNPEEIFQAVIHTTARITKQHPEKRISFISFSSAMHSVIAIDENDKPLTPCITWADN RSEGWAHKIKEELNGHEVYKRTGTPIHPMAPLSKIAWITNERKEIASKAKKYIGIKEY IFKQLFNEYVIDYSLASATGMMNLKGLDWDEEALRIAGITPDHLSKLVPTTEIFQHCS PEIAIQMGIDPETPFVIGASDGVLSNLGVNAIKKGEIAVTIGTSGAIRTIIDKPQTDE KGRIFCYALTDKHWVIGGPVNNGGIVLRWIRDEFASSEIETATRLGIDPYDVLTKIAQ RVRPGSDGLLFHPYLAGERAPLWNPDVRGSFFGLTMSHKKEHMIRAALEGVIYNLYTV FLALTECMDGPVTRIQATGGFARSEVWRQMMSDIFESEVVVPESYESSCLGACILGLY ATGKIDSFDAVSDMIGSTYRHTPIEDSAKEYRTLMPIFINLSRLLENQYTQIADYQRG LITHK*" /label="gntK CDS" gene 3584431..3585972 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /label="gntK gene" CDS 3586001..3587347 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3020045, 15849754, 1659648, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3020045, 15849754, 1659648, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gluconate/proton permease" /protein_id="NP_391887.1" /db_xref="EnsemblGenomes-Gn:BSU40070" /db_xref="EnsemblGenomes-Tr:CAB16044" /db_xref="GOA:P12012" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG10650" /db_xref="UniProtKB/Swiss-Prot:P12012" /translation="MPLIIVALGILALLFLIMGLKLNTFISLLVVSFGVALALGMPFD KVVSSIEAGIGGTLGHIALIFGLGAMLGKLIADSGGAQRIAMTLVNKFGEKNIQWAVV IASFIIGIALFFEVGLVLLIPIVFAISRELKISILFLGIPMVAALSVTHGFLPPHPGP TAIAGEYGANIGEVLLYGFIVAVPTVLIAGPLFTKFAKKIVPASFAKNGNIASLGTQK TFNLEETPGFGISVFTAMLPIIIMSVATIIDLLQETIGFADNGVLAFIRLIGNASTAM IISLLVAVYTMGIKRNIPVKTVMDSCSTAISQIGMMLLIIGGGGAFKQVLINGGVGDY VADLFKGTALSPIILAWLIAAILRISLGSATVAALSTTGLVIPLLGHSDVNLALVVLA TGAGSVIASHVNDAGFWMFKEYFGLSMKETFATWTLLETIISVAGLGFILLLSLVV*" /label="gntP CDS" gene 3586001..3587347 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /label="gntP gene" promotor_-35 3586800..3586804 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3586820..3586839 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3586829 /Source="Nicolas_upshifts" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="upshifts" CDS 3587370..3588776 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /EC_number="1.1.1.343" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 9535092, 9931298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 9535092, 9931298; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconate dehydrogenase (NAD+-dependent)" /protein_id="NP_391888.1" /db_xref="EnsemblGenomes-Gn:BSU40080" /db_xref="EnsemblGenomes-Tr:CAB16045" /db_xref="GOA:P12013" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10651" /db_xref="UniProtKB/Swiss-Prot:P12013" /translation="MFNSIGVIGLGVMGSNIALNMANKGENVAVYNYTRDLTDQLIQK LDGQSLSPYYELEDFVQSLEKPRKIFLMVTAGKPVDSVIQSLKPLLEEGDVIMDGGNS HYEDTERRYDELKEKGIGYLGVGISGGEVGALTGPSIMPGGDRDVYEKAAPILTKIAA QVGDDPCCVYIGPKGAGHFTKMVHNGIEYADMQLIAEAYTFLRETLRLPLDEIASIFE TWNQGELKSYLIEITAEILRKKDEKTGQPLIDVILDKTGQKGTGKWTSMQAIDNGIPS TIITESLFARYLSSLKEERMAAQDVLAGPEAEEKHLDKDTWIEYVRQALYMGKVCAYA QGFAQYKMSSELYGWNLPLKDIALIFRGGCIIRADFLNVISEAFSEQPNLANLLIAPY FTDKLHAYQTGLRKVVCEGISTGISFPCLTTALSYYDGYRTGRSNANLLQAQRDYFGA HTYERTDMDGVFHTNWSE*" /label="gntZ CDS" gene 3587370..3588776 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /label="gntZ gene" downshifts 3588765 /Source="Nicolas_upshifts" /id="D2072" /incds=0 /nref=128 /ntot=228 /MaxReadThrough="3.81668" /MaxDrop="5.52642" /score="20.2280166" /energy="-10.2" /TU="NA" /idTUdmin="U3151" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 3588873..3588892 /Source="Nicolas_upshift_promotors" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3588875..3589166 /Source="Nicolas_S_feature" /locus_tag="new_4118585_4118876" /HighExp="S8, Etha, Sw, T0.30H, Cold, H2O2, B60, S5, S4, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1540" upshifts 3588875 /Source="Nicolas_upshifts" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="upshifts" promotor_-35 3589139..3589146 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3589161..3589180 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3589168 /Source="Nicolas_upshifts" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3589190..3589197 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3589212..3589231 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3589215) /Source="Nicolas_upshifts" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3589218..3589232) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3589227 /Source="Nicolas_upshifts" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3589240..3589244) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3589240..3589803 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /EC_number="1.11.1.5" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932315, 14766928, 26322180" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932315, 14766928, 26322180; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (small subunit)" /protein_id="NP_391889.1" /db_xref="EnsemblGenomes-Gn:BSU40090" /db_xref="EnsemblGenomes-Tr:CAB16046" /db_xref="GOA:P80239" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017559" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11385" /db_xref="UniProtKB/Swiss-Prot:P80239" /translation="MSLIGKEVLPFEAKAFKNGEFIDVTNEDLKGQWSVFCFYPADFS FVCPTELEDLQEQYAALKELGVEVYSVSTDTHFVHKGWHDSSEKISKITYAMIGDPSQ TISRNFDVLDEETGLADRGTFIIDPDGVIQTVEINAGGIGRDASNLVNKVKAAQYVRQ NPGEVCPAKWEEGGETLTPSLDLVGKI*" /label="ahpC CDS" gene 3589240..3589803 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /label="ahpC gene" CDS 3589817..3591346 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /EC_number="1.6.99.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932314, 14766928, 16232966, 23899494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932314, 14766928, 16232966, 23899494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (large subunit)" /protein_id="NP_391890.1" /db_xref="EnsemblGenomes-Gn:BSU40100" /db_xref="EnsemblGenomes-Tr:CAB16047" /db_xref="GOA:P42974" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR012081" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11204" /db_xref="UniProtKB/Swiss-Prot:P42974" /translation="MVLDANIKAQLNQYMQLIENDIVLKVSAGEDDTSKDMLALVDEL ASMSSKISVEKAELNRTPSFSVNRVGEDTGVTFAGIPLGHEFTSLVLALLQVSGRPPK VDQKVIDQVKKISGEYHFESYISLTCHNCPDVVQALNMMSVLNPNITHTMIDGAAYKA EVESKNIMAVPTVYLNGESFGSGRMTLEEILAKMGSGTDASEFADKEPFDVLVVGGGP AGASAAIYTARKGIRTGVVAERFGGQVLDTMSIENFISVKATEGPKLAASLEEHVKEY DIDVMNLQRAKRLEKKDLFELELENGAVLKSKTVILSTGARWRNVNVPGEQEFKNKGV AYCPHCDGPLFEGKDVAVIGGGNSGIEAAIDLAGIVNHVTVLEFAPELKADEVLQKRL YSLPNVTVVKNAQTKEITGDQSVNGITYVDRETGEEKHVELQGVFVQIGLVPNTEWLE GTVERNRMGEIIVDKHGATSVPGLFAAGDCTDSAYNQIIISMGSGATAALGAFDYLIR N*" /label="ahpF CDS" gene 3589817..3591346 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /label="ahpF gene" downshifts complement(3591173) /Source="Nicolas_upshifts" /id="D2073" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="3.25325" /MaxDrop="3.69049" /score="1.76901559" /energy="-18" /TU="NA" /idTUdmin="U3157" /TUdmin=198 /isTUend="FALSE" /label="downshifts" downshifts 3591339 /Source="Nicolas_upshifts" /id="D2074" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="3.92009" /MaxDrop="8.88048" /score="33.1934883" /energy="-19.6" /TU="U3154" /idTUdmin="U3156" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3591372..3591455) /Source="Nicolas_S_feature" /locus_tag="new_4121082_4121165_c" /HighExp="G150, C30, LPhT, G135, S8, LBGstat, T0.30H, G180, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1541" downshifts complement(3591415) /Source="Nicolas_upshifts" /id="D2075" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.37922" /MaxDrop="4.44094" /score="1.76901559" /energy="-18" /TU="U3157" /idTUdmin="U3157" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(3591456..3592895) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8125345, 14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8125345, 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-6-phospho-beta-glucosidase" /protein_id="NP_391891.1" /db_xref="EnsemblGenomes-Gn:BSU40110" /db_xref="EnsemblGenomes-Tr:CAB16048" /db_xref="GOA:P42973" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11203" /db_xref="UniProtKB/Swiss-Prot:P42973" /translation="MGNMPKDFLWGGALAAHQFEGGWNQGGKGPSVVDVMTAGAHGVP RKITDTIEENEFYPNHEAIDFYHRYKEDIALFAEMGLKCLRTSIGWSRIFPKGDEAEP NEAGLQFYDDVFDELLKHGIEPVITLSHFEMPLHLAREYGGFRNRKVVDFFVNFAEAC FTRYKDKVKYWMTFNEINNQMDVNNPLFLWTNSGVVVGENENAKEVMYQTAHHELVAS ALAVAKGKDINPEFQIGAMVSHVPIYPFSSNPEDVMLAEEEMRQRYFFPDVQVRGYYP SYALKEFEREGYNITFEDGDDEILRNGTVDYLGFSYYMSTTVKSDVKNDNTGDIVNGG LPNGVENPYITSSDWGWAIDPTGLRYTLNRFYDRYQIPLFIVENGFGAVDTLEEDGKV HDPERIQYLKSHIEALKKAVTYDGVDLIGYTPWGIIDIVSFTTGEMKKRYGMIYVDRD NEGNGSMKRYKKDSFEWYKNVIQTNGEEL*" /label="bglA CDS" gene complement(3591456..3592895) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /label="bglA gene" CDS complement(3592909..3593139) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /EC_number="2.7.1.-" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867744, 28731580" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867744, 28731580; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucose phosphotransferase system enzyme IIA component" /protein_id="NP_391892.1" /db_xref="EnsemblGenomes-Gn:BSU40120" /db_xref="EnsemblGenomes-Tr:CAB16049" /db_xref="GOA:O32292" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG14172" /db_xref="UniProtKB/Swiss-Prot:O32292" /translation="MVTPTKHAIGLRSASGVELLAHIGLDTVTFDGTPFSLKVKEGDT VKKGEVLVEFDKAFIEDIEESALHQKIFTVVS*" /label="ptsJ CDS" gene complement(3592909..3593139) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /label="ptsJ gene" S_feature complement(3593140..3593351) /Source="Nicolas_S_feature" /locus_tag="new_4122850_4123061_c" /HighExp="G150, LPhT, T0.30H, Diami, G135, LBGstat, G180, Oxctl, Lbexp, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1542" promotor_-10 complement(3593348..3593367) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3593353) /Source="Nicolas_upshifts" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3593382..3593389) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3593415..3593422 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3593433..3593452 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3593448 /Source="Nicolas_upshifts" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="upshifts" CDS 3593483..3594193 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_391893.1" /db_xref="EnsemblGenomes-Gn:BSU40130" /db_xref="EnsemblGenomes-Tr:CAB16050" /db_xref="GOA:Q45591" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3BWG" /db_xref="SubtiList:BG11484" /db_xref="UniProtKB/Swiss-Prot:Q45591" /translation="MLKYQQIATEIETYIEEHQLQQGDKLPVLETLMAQFEVSKSTIT KSLELLEQKGAIFQVRGSGIFVRKHKRKGYISLLSNQGFKKDLEDFNVTSKVIELDVR KPTPEAAENLNIGMDEDIYYVKRVRYINGQTLCYEESYYTKSIVTYLNNEIVSHSIFH YIREGLGLKIGFSDLFLHVGQLNEEEAEYLGLEAGLPKLYIESIFHLTNGQPFDYSKI SYNYEQSQFVVQANSFLL*" /label="yydK CDS" gene 3593483..3594193 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /label="yydK gene" CDS 3594221..3594379 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097799.1" /db_xref="EnsemblGenomes-Gn:BSU40139" /db_xref="EnsemblGenomes-Tr:CAX52714" /db_xref="GOA:C0H3T8" /db_xref="UniProtKB/Swiss-Prot:C0H3T8" /translation="MYKIIIPAILAIFALWILLQISLEMSIVKNPMNYFIVFIIFFLF VKMVKEKQ*" /label="yyzN CDS" gene 3594221..3594379 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /label="yyzN gene" downshifts 3594456 /Source="Nicolas_upshifts" /id="D2076" /incds=0 /nref=16 /ntot=177 /MaxReadThrough="0.96913" /MaxDrop="4.2349" /score="-9.95345673" /energy="-14.7" /TU="NA" /idTUdmin="U3158" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3594510..3595232) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /function="16.1: Circulate" /function="16.3: Control" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="permease for export of regulatory peptide LiaD*" /protein_id="NP_391894.1" /db_xref="EnsemblGenomes-Gn:BSU40140" /db_xref="EnsemblGenomes-Tr:CAB16051" /db_xref="GOA:Q45592" /db_xref="SubtiList:BG11483" /db_xref="UniProtKB/Swiss-Prot:Q45592" /translation="MKLEFKKSISNKVIIILGAMFVFLFLLGYFLLVGIDKVSNVTPE MFFFSSYTVATQFGLMLFSFVIAFFINREYSNKNILFYKLIGENIYTFFYKKIAVLFL ECFAFITLGLLIISLMYHDFSHFALLLFLFSAVILQYILIIGTISVLCPNILISIGVS IVYWMTSVILVAISNKTFGFIAPFEAGNTMYPRIERVLQSDNMTLGSNDVLFIILYLV SIIIINAIVLRFSKTRWIKMGL*" /label="liaM CDS" gene complement(3594510..3595232) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /label="liaM gene" downshifts complement(3594522) /Source="Nicolas_upshifts" /id="D2077" /incds=0 /nref=225 /ntot=267 /MaxReadThrough="2.70741" /MaxDrop="6.21099" /score="7.49162587" /energy="-10.5" /TU="NA" /idTUdmin="U3160" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-35 3595133..3595136 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3595152..3595156 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3595167 /Source="Nicolas_upshifts" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3595253..3595882) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter for regulatory peptide LiaD* (ATP-binding protein)" /protein_id="NP_391895.1" /db_xref="EnsemblGenomes-Gn:BSU40150" /db_xref="EnsemblGenomes-Tr:CAB16052" /db_xref="GOA:Q45593" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11482" /db_xref="UniProtKB/Swiss-Prot:Q45593" /translation="MNIANYTLKVKGKTLLQDTDLHFSSGKINHVVGKNGVGKSQLAK DFLLNNSKRIGRDIRQNVSLISSSSNIPNDVSKDFLLHFLSKKFDAKMIDKIAYLLNL DNIDGKVLIKNLSDGQKQKLKLLSFLLEDKNIIVLDEITNSLDKKTVIEIHGFLNKYI QENPEKIIINITHDLSDLKAIEGDYYIFNHQEIQQYHSVDKLIEVYINE*" /label="liaL CDS" gene complement(3595253..3595882) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /label="liaL gene" S_feature complement(3595883..3596031) /Source="Nicolas_S_feature" /locus_tag="new_4125593_4125741_c" /HighExp="T-0.40H, LoTm, T-2.40H, T0.0H, M9-tran, SMMPr, T-1.40H, GM 150, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1543" CDS complement(3596032..3596790) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease acting on modified factor LiaD" /protein_id="NP_391896.2" /db_xref="EnsemblGenomes-Gn:BSU40160" /db_xref="EnsemblGenomes-Tr:CAB16053" /db_xref="GOA:Q45594" /db_xref="SubtiList:BG11481" /db_xref="UniProtKB/Swiss-Prot:Q45594" /translation="MKILKYEDEKYEVLVQNNVFIKDKKSGEYYKNSLNSLSDKQLLR FKMYKEKVSPKFFYLFLSFTALMFILNYIHLIKLQNGLSSVFYGWKMWIIIVIYFIMN IVLHELGHIYSLKFFGKNFDKVGFKLNFYVFPAFYVQLNETYMLSRNEKIIVHLFGLF INYLLINTLELINQFTFSSEALTMAFMLFSSTLLWNLIPILNSDGYKILLAFLSLDEY SRFKTNHWLVLTIQIIGIGLAVNSVVHWILYIVN*" /label="liaK CDS" gene complement(3596032..3596790) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /label="liaK gene" promotor_-10 complement(3596480..3596499) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3596496) /Source="Nicolas_upshifts" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3596512..3596519) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3596771..3597730) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /EC_number="5.1.1.-" /experiment="publication(s) with functional evidences, PMID:17921301, 18307109, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17921301, 18307109, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="AdoMet radical amino acid epimerase modifying factor LiaD" /protein_id="NP_391897.1" /db_xref="EnsemblGenomes-Gn:BSU40170" /db_xref="EnsemblGenomes-Tr:CAB16054" /db_xref="GOA:Q45595" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR023904" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG11480" /db_xref="UniProtKB/Swiss-Prot:Q45595" /translation="MYNKTVSINLDSRCNASCDHCCFSSSPTSTTRMEKEYIRELVTE FAKNKTIQVISFTGGEVFLDYKFLKELMEIIKPYEKQITLISNGFWGLSKKKVQEYFH DMNSLNVIALTISYDEYHAPFVKSSSIKNILEHSRKYPDIDISLNMAVTKDKMSNHIL EELGDSILGVKITKFPMISVGAAKTRIKQENIHKFYSLEDEDSLHCPGYDIVYHHDGE IYPCCSPAIFETKITLREEYNQSFERTVEKLNSNLLLFILRKEGFKWFLNILKENNKI EEFDIPYEFSSICGVCGSLFNSAEKINYFYPYMEKYYNENFKV*" /label="liaE CDS" gene complement(3596771..3597730) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /label="liaE gene" downshifts 3597719 /Source="Nicolas_upshifts" /id="D2078" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.40583" /MaxDrop="2.5017" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_feature 3597766..3597769 /Source="Nicolas_upshift_promotors" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3597774 /Source="Nicolas_upshifts" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3597788..3597937) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 17921301, 28644475; Product type r: regulator" /codon_start=1 /transl_table=11 /product="precursor of exported modified peptide (epipeptide) controlling LiaRS activity" /protein_id="NP_391898.1" /db_xref="EnsemblGenomes-Gn:BSU40180" /db_xref="EnsemblGenomes-Tr:CAB16055" /db_xref="InterPro:IPR023898" /db_xref="SubtiList:BG11479" /db_xref="UniProtKB/Swiss-Prot:Q45596" /translation="MKKEITNNETVKNLEFKGLLDESQKLAKVNDLWYFVKSKENRWI LGSGH*" /label="liaD CDS" gene complement(3597788..3597937) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /label="liaD gene" downshifts complement(3597795) /Source="Nicolas_upshifts" /id="D2079" /incds=0 /nref=99 /ntot=172 /MaxReadThrough="7.62324" /MaxDrop="6.01674" /score="7.49162587" /energy="-10.5" /TU="U3163" /idTUdmin="U3167" /TUdmin=2794 /isTUend="FALSE" /label="downshifts" misc_feature 3597846..3597863 /Source="Nicolas_upshift_promotors" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3597851 /Source="Nicolas_upshifts" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3597932 /Source="Nicolas_upshifts" /id="D2080" /incds=0 /nref=99 /ntot=170 /MaxReadThrough="2.55247" /MaxDrop="5.95806" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3597958..3597977) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3597979) /Source="Nicolas_upshifts" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3597992..3597999) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3598272..3598279 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3598294..3598313 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3598298 /Source="Nicolas_upshifts" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="upshifts" CDS 3598409..3600334 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /EC_number="3.1.3.11" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:221467, 9696785, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 221467, 9696785, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphatase" /protein_id="NP_391899.2" /db_xref="EnsemblGenomes-Gn:BSU40190" /db_xref="EnsemblGenomes-Tr:CAB16056" /db_xref="GOA:Q45597" /db_xref="InterPro:IPR009164" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11478" /db_xref="UniProtKB/Swiss-Prot:Q45597" /translation="MESKYLDLLAQKYDCEEKVVTEIINLKAILNLPKGTEHFVSDLH GEYQAFQHVLRNGSGRVKEKIRDIFSGVIYDREIDELAALVYYPEDKLKLIKHDFDAK EALNEWYKETIHRMIKLVSYCSSKYTRSKLRKALPAQFAYITEELLYKTEQAGNKEQY YSEIIDQIIELGQADKLITGLAYSVQRLVVDHLHVVGDIYDRGPQPDRIMEELINYHS VDIQWGNHDVLWIGAYSGSKVCLANIIRICARYDNLDIIEDVYGINLRPLLNLAEKYY DDNPAFRPKADENRPEDEIKQITKIHQAIAMIQFKLESPIIKRRPNFNMEERLLLEKI DYDKNEITLNGKTYQLENTCFATINPEQPDQLLEEEAEVIDKLLFSVQHSEKLGRHMN FMMKKGSLYLKYNGNLLIHGCIPVDENGNMETMMIEDKPYAGRELLDVFERFLREAFA HPEETDDLATDMAWYLWTGEYSSLFGKRAMTTFERYFIKEKETHKEKKNPYYYLREDE ATCRNILAEFGLNPDHGHIINGHTPVKEIEGEDPIKANGKMIVIDGGFSKAYQSTTGI AGYTLLYNSYGMQLVAHKHFNSKAEVLSTGTDVLTVKRLVDKELERKKVKETNVGEEL LQEVAILESLREYRYMK*" /label="fbp CDS" gene 3598409..3600334 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /label="fbp gene" S_feature 3600335..3601699 /Source="Nicolas_S_feature" /locus_tag="new_4130045_4131409" /HighExp="Lbstat, dia5, C30, Gly, Etha, dia15, C90, Fru, G135, Mal" /AntisenseName="yydD" /AntisenseCor="0.44422072328838003" /AntisenseRegPval="-13.7" /CDS_PredictionProba="0.22050400000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1544" S_feature complement(3600547..3600867) /Source="Nicolas_S_feature" /locus_tag="new_4130257_4130577_c" /HighExp="Cold, C30, M/G, S8, Fru, nit, Glu, BMM, Heat, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1545" CDS complement(3600868..3602628) /gene="yydD" /locus_tag="BSU_40200" /old_locus_tag="BSU40200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative DNA wielding protein" /protein_id="NP_391900.1" /db_xref="EnsemblGenomes-Gn:BSU40200" /db_xref="EnsemblGenomes-Tr:CAB16057" /db_xref="InterPro:IPR018760" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11477" /db_xref="UniProtKB/Swiss-Prot:Q45598" /translation="MIVMIIKNLFVCNSQEILKEYKFNAVGVNIILGEKREDHEETNG VGKSTMIECISFLLGKTISNFYTTNEILLNKNVFIVLNVEIDGNQVFLARSFNSPKHG YTLHDTSLTFNLEEWKKVSISVYKKFIEKEILKGEKEDITFAALREYIIRDEKTGFND IVLPNRGGLKQYKLLNYLFTLPTHTEKNIKVFRDKIEKLNSEIKLIESMNINIGDLKV KEDELINEIEDYNRVIYQTKTANKYNNDTNRYSEIKSELNKIQNEIFENEHICKQYQR NIDDLNKKVTKIKELENIEKFYEDIVGFFPEEVKQNYNKVQEFYNFMVESRGSYFKDK IVKIQADLKKLNIKKQGLTEQLESSARILKSNNFIEDISIVMEEQRRKEIELAEVRLR ISDYDKKNHIFDKINELQHEILRVNSMYYDEFQSYSAIVSELKKLFNNLMDVTYNQHG FLDFEYDNRISNAKQSTTGRIKISCSIPDERSHGRLHMKINIFDLTWFLYRCINKCSL NILIHDGSYSNPDPHVKGTLLKHINSSLLENRIGQYFVTINKNELLLDDLQELESKGM IVAKLDRNNEDKNRFFGFRF*" /label="yydD CDS" gene complement(3600868..3602628) /gene="yydD" /locus_tag="BSU_40200" /old_locus_tag="BSU40200" /label="yydD gene" downshifts complement(3600911) /Source="Nicolas_upshifts" /id="D2081" /incds=0 /nref=11 /ntot=199 /MaxReadThrough="4.99391" /MaxDrop="4.47843" /score="7.49162587" /energy="-10.5" /TU="U3167" /idTUdmin="U3167" /TUdmin="-322" /isTUend="FALSE" /label="downshifts" misc_feature 3601696..3601697 /Source="Nicolas_upshift_promotors" /id="U3165" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.67032967032967" /psig="0.255744255744256" /xcortree=83 /SigmaFactorBS="aactccctctactttctaccatgaaattatagaactcttgga ctttattataattCTgttttacttcctctggaaaaaaacctacaatatcttcatagaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3601701 /Source="Nicolas_upshifts" /id="U3165" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.67032967032967" /psig="0.255744255744256" /xcortree=83 /SigmaFactorBS="aactccctctactttctaccatgaaattatagaactcttgga ctttattataattCTgttttacttcctctggaaaaaaacctacaatatcttcatagaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3602628..3603026) /gene="yydC" /locus_tag="BSU_40210" /old_locus_tag="BSU40210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391901.1" /db_xref="EnsemblGenomes-Gn:BSU40210" /db_xref="EnsemblGenomes-Tr:CAB16058" /db_xref="SubtiList:BG11476" /db_xref="UniProtKB/Swiss-Prot:Q45599" /translation="MIDLKIETAENILKYSYVLLENEFKNIQIGNDLIPLVNNSPLKK EKAERPEMNHFLLTKYNAVEENILYSSKILYELLEKEKHIDQLFLDYAKSQGIIINLN IERILYLSLTFLYSLGKVSFNQNMISRTES*" /label="yydC CDS" gene complement(3602628..3603026) /gene="yydC" /locus_tag="BSU_40210" /old_locus_tag="BSU40210" /label="yydC gene" CDS complement(3603019..3604464) /gene="yydB" /locus_tag="BSU_40220" /old_locus_tag="BSU40220" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphohydrolase" /protein_id="NP_391902.1" /db_xref="EnsemblGenomes-Gn:BSU40220" /db_xref="EnsemblGenomes-Tr:CAB16059" /db_xref="GOA:Q45600" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11475" /db_xref="UniProtKB/Swiss-Prot:Q45600" /translation="MKVRFLQISDLHFQFQNYDTIVMRDKLLDFIEVLRRESDFDFLL LTGDIAHKGDVYNEDVKEYLNGIIKSMGLSKNNVHLVPGNHDISRDMTRTLLIDSIMK SPNPSEMLDKLDQKATNILVEGQRKFFDFYEDFMGVKYPEEDLHFLYQSEKYNVLSIN TCLLSDKKGEEGTLLTAQMKLYKAIRKMNKEKNKGKVLNIAIGHHTLGCIESSERESI KAHFDDYFIDLYLAGHVHDSSFNITANTNENPFLELVSGAIIKDEYATPEFISVDVNL DNGETEVTYYIWNTEYKYWSKNNQGGRRLQEGKLNYKINRLESLIEKEIEDNDDKIDE DEFKSFIIDFHEYRESYKTFTSNFDNQIGLDKKFYDMKSGETFKRKFDSYSEYFGVIN HIMDSTSYVSADKKELIAETIVDKYLEFHNQYNNGDEIFVKIVNEIYLECHSVLPYSK ALTKKYIKILTCWCIYECEIFNDNKRSVKND*" /label="yydB CDS" gene complement(3603019..3604464) /gene="yydB" /locus_tag="BSU_40220" /old_locus_tag="BSU40220" /label="yydB gene" promotor_-35 3603714..3603721 /Source="Nicolas_upshift_promotors" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3603733..3603752 /Source="Nicolas_upshift_promotors" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3603743..3604792 /Source="Nicolas_S_feature" /locus_tag="new_4133453_4134502" /HighExp="C30, Salt, Gly, S8, Etha, LPhT, T0.30H, Heat, C90, M9-stat" /AntisenseName="yydB" /AntisenseCor="0.36202116146901597" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.431" /TUlongSig="NA" /TUlongPSig="NA" /label="S1546" upshifts 3603743 /Source="Nicolas_upshifts" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3604465..3604725) /Source="Nicolas_S_feature" /locus_tag="new_4134175_4134435_c" /HighExp="Cold, M0t90, Lbtran, M40t90, Lbstat, T0.30H, MG 150, M40t45, Gly, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1547" CDS complement(3604726..3605205) /gene="rlmH" /locus_tag="BSU_40230" /old_locus_tag="BSU40230" /EC_number="2.1.1.177" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18755835, 20817755, 22411911, 22720735, 28428565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (pseudouridine1915-N3)-methyltransferase" /protein_id="NP_391903.1" /db_xref="EnsemblGenomes-Gn:BSU40230" /db_xref="EnsemblGenomes-Tr:CAB16060" /db_xref="GOA:Q45601" /db_xref="InterPro:IPR003742" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1TO0" /db_xref="SubtiList:BG11474" /db_xref="UniProtKB/Swiss-Prot:Q45601" /translation="MNINIVTIGKLKEKYLKQGIEEYTKRLSAYAKIDIIELPDEKAP ENLSDQDMKIIKDKEGDRILSKISPDAHVIALAIEGKMKTSEELADTIDKLATYGKSK VTFVIGGSLGLSDTVMKRADEKLSFSKMTFPHQLMRLILVEQIYRAFRINRGEPYHK* " /label="rlmH CDS" gene complement(3604726..3605205) /gene="rlmH" /locus_tag="BSU_40230" /old_locus_tag="BSU40230" /label="rlmH gene" S_feature complement(3605206..3605285) /Source="Nicolas_S_feature" /locus_tag="new_4134916_4134995_c" /HighExp="dia5, LBGtran, T0.30H, Diami, Cold, M0t90, dia0, M0t45, M40t45, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1548" CDS complement(3605286..3605456) /gene="yyzF" /locus_tag="BSU_40239" /old_locus_tag="BSU40239" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097800.1" /db_xref="EnsemblGenomes-Gn:BSU40239" /db_xref="EnsemblGenomes-Tr:CAX52715" /db_xref="InterPro:IPR025626" /db_xref="UniProtKB/Swiss-Prot:C0H3T9" /translation="MKQAYYSCEEHIETVLDMYIDDHELPPEIRKIEHTNSLSTACEL CGDPAVYIVGNE*" /label="yyzF CDS" gene complement(3605286..3605456) /gene="yyzF" /locus_tag="BSU_40239" /old_locus_tag="BSU40239" /label="yyzF gene" promotor_-10 complement(3605497..3605516) /Source="Nicolas_upshift_promotors" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3605513) /Source="Nicolas_upshifts" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3605530..3605535) /Source="Nicolas_upshift_promotors" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3605579..3605586 /Source="Nicolas_upshift_promotors" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3605599..3605618 /Source="Nicolas_upshift_promotors" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3605616 /Source="Nicolas_upshifts" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="upshifts" CDS 3605641..3606054 /gene="yycS" /locus_tag="BSU_40240" /old_locus_tag="BSU40240" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21911367; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391904.1" /db_xref="EnsemblGenomes-Gn:BSU40240" /db_xref="EnsemblGenomes-Tr:CAB16061" /db_xref="SubtiList:BG11472" /db_xref="UniProtKB/Swiss-Prot:Q45603" /translation="MRFRWVWLFVIMLLLAECQPSYWVLEKDRIGEGSPDLEIYANYL QMHDDVKGYQVFTISEGKKMVVVSLGSSEKDKKLEVSDVKFSSKETIVTVERKPAPTA NEKNPFILIGLDKIEGDLIVQDETGDRFEETDYQQ*" /label="yycS CDS" gene 3605641..3606054 /gene="yycS" /locus_tag="BSU_40240" /old_locus_tag="BSU40240" /label="yycS gene" downshifts 3606034 /Source="Nicolas_upshifts" /id="D2082" /incds=0 /nref=17 /ntot=131 /MaxReadThrough="1.50241" /MaxDrop="5.73792" /score="16.0382598" /energy="-10.8" /TU="NA" /idTUdmin="U3168" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3606088..3607314) /gene="yycR" /locus_tag="BSU_40250" /old_locus_tag="BSU40250" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18820069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_391905.1" /db_xref="EnsemblGenomes-Gn:BSU40250" /db_xref="EnsemblGenomes-Tr:CAB16062" /db_xref="GOA:Q45604" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014184" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11471" /db_xref="UniProtKB/Swiss-Prot:Q45604" /translation="MGGMALTGNKAVVYKGKGTVAVEDIGYPELILRDGPGVPKANVN RKCEHGVILKVITTNICGSDQHMVRGRTTAPEGLVLGHEITGEVIETGRDVEFIKKGD IVSVPFNIACGRCVMCKTQKTHVCLNVNPDRPGSAYGYVDMGGWVGGQSEYVMVPYAD FQLLVFPDKEQALEKILDLTMLSDIFPTGFHGAYTAGVQTGSTVYIAGAGPVGLAAAH SAQLLGASTVIVGDLNEDRLAQARSFGCETVNVQKHDRLGEQIEQILGEPTVDAAVDC VGFEASGHGNQGEAPAAVLNSIMDVTQVGGSLGIPGLYVTEDPGAKDADAKTGSLKIR FGLGWAKAHTFVTGQTPAMTYNRNLMKAILSGRAQIAKAVNATVISLDDAPKGYSDFD KGAAKKFVIDPHGTLK*" /label="yycR CDS" gene complement(3606088..3607314) /gene="yycR" /locus_tag="BSU_40250" /old_locus_tag="BSU40250" /label="yycR gene" downshifts complement(3606103) /Source="Nicolas_upshifts" /id="D2083" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="0.14321" /MaxDrop="4.77892" /score="8.82768619" /energy="-6.2" /TU="NA" /idTUdmin="U3169" /TUdmin=7 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3607337..3607355) /Source="Nicolas_upshift_promotors" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3607342) /Source="Nicolas_upshifts" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3607367..3607375) /Source="Nicolas_upshift_promotors" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3607377..3607547) /gene="yyzG" /locus_tag="BSU_40259" /old_locus_tag="BSU40259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097801.1" /db_xref="EnsemblGenomes-Gn:BSU40259" /db_xref="EnsemblGenomes-Tr:CAX52716" /db_xref="GOA:C0H3U0" /db_xref="UniProtKB/Swiss-Prot:C0H3U0" /translation="MQTNRVILLAVMICLVSAITVFLLNGCKVDFLDIGGTIIGCFLG IFVVVRIQKKQS*" /label="yyzG CDS" gene complement(3607377..3607547) /gene="yyzG" /locus_tag="BSU_40259" /old_locus_tag="BSU40259" /label="yyzG gene" promotor_-10 complement(3607566..3607584) /Source="Nicolas_upshift_promotors" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3607584) /Source="Nicolas_upshifts" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3607598..3607604) /Source="Nicolas_upshift_promotors" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3607652..3607900) /gene="yycQ" /locus_tag="BSU_40260" /old_locus_tag="BSU40260" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391906.1" /db_xref="EnsemblGenomes-Gn:BSU40260" /db_xref="EnsemblGenomes-Tr:CAB16063" /db_xref="GOA:Q45605" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG11470" /db_xref="UniProtKB/Swiss-Prot:Q45605" /translation="MGAIAVLFIVFGFPIVAGVFGIAGHFLFKRFWVAPLIVLITSLI LLVTLASGNSSFIFWVVMYTAIALVTSVATLFLRKFFE*" /label="yycQ CDS" gene complement(3607652..3607900) /gene="yycQ" /locus_tag="BSU_40260" /old_locus_tag="BSU40260" /label="yycQ gene" CDS complement(3607916..3609079) /gene="yycP" /locus_tag="BSU_40270" /old_locus_tag="BSU40270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11557812, 16291680" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391907.2" /db_xref="EnsemblGenomes-Gn:BSU40270" /db_xref="EnsemblGenomes-Tr:CAB16064" /db_xref="InterPro:IPR011047" /db_xref="SubtiList:BG11469" /db_xref="UniProtKB/Swiss-Prot:Q45606" /translation="MKKWMITIAMLILAGIALFVFISPLKSHKTVSQQDLRNPDFLDD KEVLLYFSSSADQDAFGGGKSYALFISHDGTLSSFQMKGLELGSAKVHGDSVMLEDKN TIYTIKNGLRSHKRTYQHTGDSAGFLQNTDGFYTLYNSGYDKKGDGYRSELYRQMDGE WKKDVIPYYIRASGFHDGAIYALVPTDDGKGYQLLQIQADQKKLTYLSITEWQYREGA SVESQLAVDDQAVYVMVRGQKAHDLYQMVKINKKSGEVELHDIAEYKNDEQTIYSSMP FSFKNSFFPYDGNLYFIDGFGKVHKIDAKTGKTSIVFTLSPDKMKAEFKEITQKGSSL YFFTYTYHKPAYIEQYSLKTGKKMKEKEIGKVKDVVTPKSHLKLYDVEVMKRF*" /label="yycP CDS" gene complement(3607916..3609079) /gene="yycP" /locus_tag="BSU_40270" /old_locus_tag="BSU40270" /label="yycP gene" promotor_-10 complement(3607950..3607968) /Source="Nicolas_upshift_promotors" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3607958) /Source="Nicolas_upshifts" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3607980..3607988) /Source="Nicolas_upshift_promotors" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3609090..3609827) /gene="yycO" /locus_tag="BSU_40280" /old_locus_tag="BSU40280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_391908.1" /db_xref="EnsemblGenomes-Gn:BSU40280" /db_xref="EnsemblGenomes-Tr:CAB16065" /db_xref="SubtiList:BG11468" /db_xref="UniProtKB/Swiss-Prot:Q45607" /translation="MKLKKRVSMFLVALTMCGGLFVTPAKAVKTTNYAEEIAALQPGT TPEEIMKSASQIAKQQHVKQDVILKQFYKEITADKAEGDRLAKESGMSIMGGSSGTKK LPTSAKGNIYYTNSYTAYYNHGHVGMYSAADKIVESVPSDGVRQIAYNARDVEDNSIV QTVSVSSSQKTAAADWAVSKVGDPYSFNFVNNRNTGHDGAKNCSKLLWSAFLLKAGID IDSNGGLGVYPRDITSSSYTTTIMTIY*" /label="yycO CDS" gene complement(3609090..3609827) /gene="yycO" /locus_tag="BSU_40280" /old_locus_tag="BSU40280" /label="yycO gene" promotor_-10 complement(3609869..3609887) /Source="Nicolas_upshift_promotors" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3609875) /Source="Nicolas_upshifts" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3609901..3609909) /Source="Nicolas_upshift_promotors" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3609969..3610439) /gene="yycN" /locus_tag="BSU_40290" /old_locus_tag="BSU40290" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14635137, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391909.1" /db_xref="EnsemblGenomes-Gn:BSU40290" /db_xref="EnsemblGenomes-Tr:CAB16066" /db_xref="GOA:O32293" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1ON0" /db_xref="PDB:1UFH" /db_xref="SubtiList:BG11467" /db_xref="UniProtKB/Swiss-Prot:O32293" /translation="MTIMLTPMQTEEFRSYLTYTTKHYAEEKVKAGTWLPEDAQLLSK QVFTDLLPRGLETPHHHLWSLKLNEKDIVGWLWIHAEPEHPQQEAFIYDFGLYEPYRG KGYAKQALAALDQAARSMGIRKLSLHVFAHNQTARKLYEQTGFQETDVVMSKKL*" /label="yycN CDS" gene complement(3609969..3610439) /gene="yycN" /locus_tag="BSU_40290" /old_locus_tag="BSU40290" /label="yycN gene" downshifts complement(3609982) /Source="Nicolas_upshifts" /id="D2084" /incds=0 /nref=1 /ntot=78 /MaxReadThrough="3.78599" /MaxDrop="2.94893" /score="8.04802973" /energy="-7.6" /TU="U3175" /idTUdmin="U3174" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3610440..3610510) /Source="Nicolas_S_feature" /locus_tag="new_4140150_4140220_c" /HighExp="S4, S5, S6, LoTm, S3, S7, S8, B36, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1549" promotor_-35 3610471..3610477 /Source="Nicolas_upshift_promotors" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3610491..3610510 /Source="Nicolas_upshift_promotors" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3610492..3610511) /Source="Nicolas_upshift_promotors" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3610492 /Source="Nicolas_upshifts" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3610510) /Source="Nicolas_upshifts" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3610512..3610787) /Source="Nicolas_S_feature" /locus_tag="new_4140222_4140497_c" /HighExp="S4, S5, S6, S7, S8, S3, B36, BT, LoTm, T5.0H" /AntisenseName="rapG" /AntisenseCor="-0.20647217228472101" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1550" promotor_-35 complement(3610526..3610533) /Source="Nicolas_upshift_promotors" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3610550..3611647 /gene="rapG" /locus_tag="BSU_40300" /old_locus_tag="BSU40300" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950930, 16553878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950930, 16553878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391910.1" /db_xref="EnsemblGenomes-Gn:BSU40300" /db_xref="EnsemblGenomes-Tr:CAB16067" /db_xref="GOA:O32294" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11466" /db_xref="UniProtKB/Swiss-Prot:O32294" /translation="MNKIAPAEIASMLNDWYLAIKKHEVEESSRLFEEVKPLLDDMEE DQEVLAYFSLLELRHKVLLHEARGQGFQHEEPSHMNATSDMLKYYFFLFEGMYEAYKN NYDIAIGLYKDAEQYLDNIPDPIEKAEFHLKVGKLYYKLGQNIVSLNHTRQAVKTFRE ETDYKKKLASALITMSGNFTEMSQFEEAEAYLDEAIRITSELEDHFFEAQLLHNFGLL HAQSGKSEEAVSKLEEALQNDEYARSAYYYHSAYLLIRELFKIKKKEQALSYYQDVKE KLTAEPNRICEAKIDILYAIYAEGGHAETFHLCKQHMDDLLSEKEYDSVRELSILAGE RYRELELYKEAAHFFYEALQIEELIKRTEVI*" /label="rapG CDS" gene 3610550..3611647 /gene="rapG" /locus_tag="BSU_40300" /old_locus_tag="BSU40300" /label="rapG gene" promotor_-10 complement(3610778..3610796) /Source="Nicolas_upshift_promotors" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="promotor_-10" upshifts complement(3610787) /Source="Nicolas_upshifts" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="upshifts" promotor_-35 complement(3610811..3610816) /Source="Nicolas_upshift_promotors" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="promotor_-35" promotor_-35 3611371..3611379 /Source="Nicolas_upshift_promotors" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3611391..3611409 /Source="Nicolas_upshift_promotors" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3611404 /Source="Nicolas_upshifts" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="upshifts" CDS 3611648..3611764 /gene="phrG" /locus_tag="BSU_40310" /old_locus_tag="BSU40310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950930, 16553878, 16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950930, 16553878, 16816200; Product type r: regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapG" /protein_id="NP_391911.1" /db_xref="EnsemblGenomes-Gn:BSU40310" /db_xref="EnsemblGenomes-Tr:CAB16068" /db_xref="InterPro:IPR030968" /db_xref="SubtiList:BG11465" /db_xref="UniProtKB/Swiss-Prot:O32295" /translation="MKRFLIGAGVAAVILSGWFIADHQTHSQEMKVAEKMIG*" /label="phrG CDS" gene 3611648..3611764 /gene="phrG" /locus_tag="BSU_40310" /old_locus_tag="BSU40310" /label="phrG gene" downshifts 3611753 /Source="Nicolas_upshifts" /id="D2085" /incds=0 /nref=39 /ntot=249 /MaxReadThrough="4.8963" /MaxDrop="7.30713" /score="31.0184314" /energy="-13.7" /TU="U3173,U3176" /idTUdmin="U3173" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" CDS complement(3612001..3612891) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /EC_number="3.5.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginase" /protein_id="NP_391912.1" /db_xref="EnsemblGenomes-Gn:BSU40320" /db_xref="EnsemblGenomes-Tr:CAB16069" /db_xref="GOA:P39138" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR014033" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG10932" /db_xref="UniProtKB/Swiss-Prot:P39138" /translation="MDKTISVIGMPMDLGQARRGVDMGPSAIRYAHLIERLSDMGYTV EDLGDIPINREKIKNDEELKNLNSVLAGNEKLAQKVNKVIEEKKFPLVLGGDHSIAIG TLAGTAKHYDNLGVIWYDAHGDLNTLETSPSGNIHGMPLAVSLGIGHESLVNLEGYAP KIKPENVVIIGARSLDEGERKYIKESGMKVYTMHEIDRLGMTKVIEETLDYLSACDGV HLSLDLDGLDPNDAPGVGTPVVGGISYRESHLAMEMLYDAGIITSAEFVEVNPILDHK NKTGKTAVELVESLLGKKLL*" /label="argI CDS" gene complement(3612001..3612891) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /label="argI gene" downshifts complement(3612007) /Source="Nicolas_upshifts" /id="D2086" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.33097" /MaxDrop="3.38667" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" downshifts complement(3612069) /Source="Nicolas_upshifts" /id="D2087" /incds=1 /nref=28 /ntot=201 /MaxReadThrough="5.16507" /MaxDrop="5.79932" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-151" /isTUend="FALSE" /label="downshifts" CDS complement(3612965..3614368) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7540694, 10648515, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 10648515, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arginine/ornithine/gamma-aminobutyrate permease" /protein_id="NP_391913.1" /db_xref="EnsemblGenomes-Gn:BSU40330" /db_xref="EnsemblGenomes-Tr:CAB16070" /db_xref="GOA:P39137" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10933" /db_xref="UniProtKB/Swiss-Prot:P39137" /translation="MNTNQDNGNQLQRTMKSRHLFMISLGGVIGTGFFLGTGFTINQA GPLGAVLSYLVGGFIMFLTMLCLGELAVAFPVSGSFQTYATKFISPAFGFAFGWLYWL GWAVTCAIEFLSAGQLMQRWFPHIDVWIWCLVFAALMFILNAITTKAFAESEFWFSGI KILIILLFIILGGAAMFGLIDLKGGEQAPFLTHFYEDGLFPNGIKAMLITMITVNFAF QGTELIGVAAGESEDPEKTIPRSIKQTVWRTLVFFVLSIIVIAGMIPWKQAGVVESPF VAVFEQIGIPYAADIMNFVILIALLSVANSGLYASTRILYAMANEGQAFKALGKTNQR GVPMYSLIVTMAVACLSLLTKFAQAETVYMVLLSLAGMSAQVGWITISLSQIMFRRKY IREGGKIEDLKFKTPLYPVLPLIGLTLNTVVLISLAFDPEQRIALYCGVPFMIICYII YHVVIKKRQQANRQLEL*" /label="rocE CDS" gene complement(3612965..3614368) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /label="rocE gene" S_feature complement(3614369..3614590) /Source="Nicolas_S_feature" /locus_tag="new_4144079_4144300_c" /HighExp="Lbstat, S0, LPh, T1.30H, HPh, T2.0H, LPhT, BI, M0t90, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.884" /TUlongSig="NA" /TUlongPSig="NA" /label="S1551" CDS complement(3614591..3615796) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /EC_number="2.6.1.13" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7540694, 9383188, 22720735, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 9383188, 22720735, 23869754; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine aminotransferase" /protein_id="NP_391914.1" /db_xref="EnsemblGenomes-Gn:BSU40340" /db_xref="EnsemblGenomes-Tr:CAB16071" /db_xref="GOA:P38021" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR010164" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR034757" /db_xref="SubtiList:BG10722" /db_xref="UniProtKB/Swiss-Prot:P38021" /translation="MTALSKSKEIIDQTSHYGANNYHPLPIVISEALGAWVKDPEGNE YMDMLSAYSAVNQGHRHPKIIQALKDQADKITLTSRAFHNDQLGPFYEKTAKLTGKEM ILPMNTGAEAVESAVKAARRWAYEVKGVADNQAEIIACVGNFHGRTMLAVSLSSEEEY KRGFGPMLPGIKLIPYGDVEALRQAITPNTAAFLFEPIQGEAGIVIPPEGFLQEAAAI CKEENVLFIADEIQTGLGRTGKTFACDWDGIVPDMYILGKALGGGVFPISCIAADREI LGVFNPGSHGSTFGGNPLACAVSIASLEVLEDEKLADRSLELGEYFKSELESIDSPVI KEVRGRGLFIGVELTEAARPYCERLKEEGLLCKETHDTVIRFAPPLIISKEDLDWAIE KIKHVLRNA*" /label="rocD CDS" gene complement(3614591..3615796) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /label="rocD gene" misc_feature complement(3615853..3615871) /Source="Nicolas_upshift_promotors" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3615856) /Source="Nicolas_upshifts" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3615966..3615971 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3615986..3616005 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3616001 /Source="Nicolas_upshifts" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="upshifts" CDS 3616037..3617422 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9194709, 12533460, 12634342, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9194709, 12533460, 12634342, 23869754; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NtrC/NifA family)" /protein_id="NP_391915.1" /db_xref="EnsemblGenomes-Gn:BSU40350" /db_xref="EnsemblGenomes-Tr:CAB16072" /db_xref="GOA:P38022" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG10723" /db_xref="UniProtKB/Swiss-Prot:P38022" /translation="MVKDSEFLTLVFQSILDEIDVGLHVVDEHGNTIVYNNKMMQIED MEKHDVLNKNLMDVFMFSKQQDSTLVQALQEGKTIKNVKQSYFNNKGQEITTINHTYP IVQDGKIRGAVEIAKDVTKLERLIRENMNKKGSTTYTFDSILGTSPAIQDVIENAKRA TRTSSSVLLAGETGTGKELFAQSIHNGSDRSGGPFISQNCAALPDSLVESILFGTKKG AFTGAVDQPGLFEQAHGGTLLLDEINSLNLSLQAKLLRALQERKIRRIGSTKDTPIDV RIIATMNEDPIDAIAGERMRKDLYYRLSVVTLIIPPLRERKEDILLLASEFIQKNNHL FQMNVEHISDDVKQFFLSYDWPGNIRELEHMIEGAMNFMTDEQTITASHLPYQYRMKI KPADIPEPETPRHQPAADLKEKMESFEKYVIENVLRKHGHNISKAAQELGISRQSLQY RLKKFSHSSNE*" /label="rocR CDS" gene 3616037..3617422 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /label="rocR gene" CDS complement(3617404..3617592) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17198402; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="fragment of putative sensor protein" /db_xref="PSEUDO:CAX52717.1" /translation="MFDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIG RGTVFLIRLPAPDYSLDE*" /label="yyzO CDS" gene complement(3617404..3617592) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /pseudo /label="yyzO gene" CDS complement(3617709..3617837) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514013.1" /translation="MPGCFDMQKKLNRGHARSVEKGYIEYEEKYKMDVTRETANGS*" /label="hypothetical protein CDS" gene complement(3617709..3617837) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /label="gene" downshifts 3617761 /Source="Nicolas_upshifts" /id="D2088" /incds=0 /nref=1 /ntot=146 /MaxReadThrough="0.86899" /MaxDrop="2.90385" /score="20.2816165" /energy="-10.8" /TU="NA" /idTUdmin="U3178" /TUdmin=110 /isTUend="FALSE" /label="downshifts" CDS complement(3617857..3619059) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /EC_number="3.4.21.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 16030236, 25384476" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 16030236, 25384476; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation membrane serine protease" /protein_id="NP_391916.1" /db_xref="EnsemblGenomes-Gn:BSU40360" /db_xref="EnsemblGenomes-Tr:CAB16073" /db_xref="GOA:P39668" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG11054" /db_xref="UniProtKB/Swiss-Prot:P39668" /translation="MVDYEREEEHTTPEQPKRSKKGYFLSSLIGVIVGAVLMAFIMPY LSNEGLDTGALDQQQNNNGRESIRTVNVSVNNAVTKIVSNMSPAVVGVVNIQKSDIWG ESGEAGSGSGVIYKKNDHSAYVVTNHHVIEGASQIEISLKDGSRVSADLVGSDQLMDL AVLRVKSDKIKAVADFGNSDKVKSGEPVIAIGNPLGLEFAGSVTQGVISGTERAIPVD SNGDGQPDWNAEVLQTDAAINPGNSGGALLNMDGKVIGINSMKIAESAVEGIGLSIPS KLVIPVIEDLERYGKVKRPFLGIEMKSLSDIASYHWDETLKLPKNVTNGAVVMGVDAF SPAGKAGLKELDVITEFDGYKVNDIVDLRKRLYQKKVGDRVKVKFYRGGKEKSVDIKL SSADQLGS*" /label="htrC CDS" gene complement(3617857..3619059) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /label="htrC gene" downshifts complement(3617881) /Source="Nicolas_upshifts" /id="D2089" /incds=0 /nref=134 /ntot=253 /MaxReadThrough="2.3073" /MaxDrop="5.06813" /score="5.6507537" /energy="-15" /TU="NA" /idTUdmin="U3179" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3619091..3619102) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3619091) /Source="Nicolas_upshifts" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3619117..3619123) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3619141..3619935) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9829949, 16030236, 21169496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391917.2" /db_xref="EnsemblGenomes-Gn:BSU40370" /db_xref="EnsemblGenomes-Tr:CAB16074" /db_xref="GOA:C0SP91" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11464" /db_xref="UniProtKB/Swiss-Prot:C0SP91" /translation="MSLQFSVLASGSTGNAFYLETEDHAFLVDAGLSGKAMDGLMAQI GRKLDDVDGIFVTHEHSDHIKGLGVVARKYKLPIYANEKTWKAMENQIGKIDTDQKFV FPMETVKSFGGLDVESFGVSHDAAEPMFYVFHYSGRKLALMTDTGYVSDRMKGIIRSA NVFVFESNHDVGMLQMGRYPWSIKRRILSDVGHVSNEDAALAMTDVIGDETSRIYLAH LSQDNNMKELARMSVQQTLASKGFVTGETFDLYDTDPKKATPLCAV*" /label="walJ CDS" gene complement(3619141..3619935) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /label="walJ gene" CDS complement(3619957..3620799) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 17307848, 17307850, 18408157, 21219466" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 17307848, 17307850, 18408157, 21219466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK" /protein_id="NP_391918.1" /db_xref="EnsemblGenomes-Gn:BSU40380" /db_xref="EnsemblGenomes-Tr:CAB16075" /db_xref="GOA:Q45612" /db_xref="InterPro:IPR018604" /db_xref="PDB:2O3O" /db_xref="SubtiList:BG11463" /db_xref="UniProtKB/Swiss-Prot:Q45612" /translation="MEWNKTKSIFIVAFLILDIFLGYQFFQKWQATGKEYEVIKNDVE HDMKADHITYEGLNKEATEGYRITANQKSFSKEEIEALKDQKPLMDMPSDDHKVTSLK MKFANPIALSKKDIEDDAQALVSSKIQDGEKYKLWKVDKSKKEIIFFQTYEGHYIYQK TDNPSNMIGQVVLHLNGKNEVVSYDQTTLETFKQIQKESLITEMDAVELLYYQNQLKE YSTVKSCKFGYVAQYPLTSTQVLAPVWRITVEYEKKVNGEKKTVQEYFTVNALESTIL DTDQ*" /label="walI CDS" gene complement(3619957..3620799) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /label="walI gene" CDS complement(3620786..3622153) /gene="walH" /locus_tag="Delta6_BSU_40390_SNPvariant" /old_locus_tag="BSU_40390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 16600972, 17307850, 26999783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 16600972, 17307850, 26999783; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK(YycFG)" /protein_id="NP_391919.1" /db_xref="EnsemblGenomes-Gn:BSU40390" /db_xref="EnsemblGenomes-Tr:CAB16076" /db_xref="GOA:Q794W0" /db_xref="InterPro:IPR009996" /db_xref="PDB:2FGT" /db_xref="SubtiList:BG11462" /db_xref="UniProtKB/Swiss-Prot:Q794W0" /modified_by="User" /translation="MKRENIKTILLTVLVVISLVFTWGIWTFQPNFSEGSSSTESTVR VKHKIEKTTQKLSETVRPRDMFIHDDGAHYKVDDNALYEEIWSDLPHWDVKGIKDISD QYDKAGFKSWFYGIGGSEAKLDLQFSDTIPIDIFQTLFKWSNQSFEYSSFDHILIPFN ETKANKKIYLVSYSKQLILEVTVESANYRNIMNDLKNRQSNMPAFSLFSIGSKKEFLL PNKPLTMDKKEFVTESIKTNTFKQALFSDPSIVREDSNYTNRNVLTDGISRLDVNLSQ RQVQFQQRNLVQSTSYQTGELIKKSQKYLEDTGSWTDHYQFFNINDSQQLSFYIFMDQ IPVINSTAKPFGATSAITVQWANDDILSYKRPNYSLGTNPIKTSETELMGGSEVKMLL SKQTAYDTDKIDQIFLAYQLVSTSTNDDPLVELEPVWAMKVNGKIVPITKDLLRKEGA NSGVE*" /label="Delta6_BSU_40390_SNPvariant" gene complement(3620786..3622153) /gene="walH" /locus_tag="Delta6_BSU_40390_SNPvariant" /old_locus_tag="BSU_40390" /modified_by="User" /label="Delta6_BSU_40390_SNPvariant" Polymorphism join(3621380,3621382) /Source="geneious" /ID="SNP_BsDelta6_4151091_4151091" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="N -> T" /CDS_Position=773 /Change="T -> G" /Codon_Change="AAC -> ACC" /Coverage=184 /locus_tag="BSU_40390" /Protein_Effect="Substitution" /Reference_Frequency="0.5%" /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=183 /comment="Delta6_BSU_40390_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(3622143..3623978) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YycG]" /protein_id="NP_391920.1" /db_xref="EnsemblGenomes-Gn:BSU40400" /db_xref="EnsemblGenomes-Tr:CAB16077" /db_xref="GOA:Q45614" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3SL2" /db_xref="SubtiList:BG11461" /db_xref="UniProtKB/Swiss-Prot:Q45614" /translation="MNKVGFFRSIQFKITLIYVLLIIIAMQIIGVYFVNQVEKSLISS YEQSLNQRIDNLSYYIEQEYKSDNDSTVIKDDVSRILNDFTKSDEVREISFVDKSYEV VGSSKPYGEEVAGKQTTDLIFKRIFSTKQSYLRKYYDPKSKIRVLISAKPVMTENQEV VGAIYVVASMEDVFNQMKTINTILASGTGLALVLTALLGIFLARTITHPLSDMRKQAM ELAKGNFSRKVKKYGHDEIGQLATTFNHLTRELEDAQAMTEGERRKLASVIAYMTDGV IATNRNGAIILLNSPALELLNVSRETALEMPITSLLGLQENYTFEDLVEQQDSMLLEI ERDDELTVLRVNFSVIQREHGKIDGLIAVIYDVTEQEKMDQERREFVANVSHELRTPL TTMRSYLEALAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNRE WIQIVRFMSLIIDRFEMTKEQHVEFIRNLPDRDLYVEIDQDKITQVLDNIISNALKYS PEGGHVTFSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGL GLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEEQEDDWDEA*" /label="walK CDS" gene complement(3622143..3623978) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /label="walK gene" CDS complement(3623986..3624693) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YycF]" /protein_id="NP_391921.1" /db_xref="EnsemblGenomes-Gn:BSU40410" /db_xref="EnsemblGenomes-Tr:CAB16078" /db_xref="GOA:P37478" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2D1V" /db_xref="PDB:2ZWM" /db_xref="PDB:3F6P" /db_xref="SubtiList:BG10001" /db_xref="UniProtKB/Swiss-Prot:P37478" /translation="MDKKILVVDDEKPIADILEFNLRKEGYEVHCAHDGNEAVEMVEE LQPDLILLDIMLPNKDGVEVCREVRKKYDMPIIMLTAKDSEIDKVIGLEIGADDYVTK PFSTRELLARVKANLRRQLTTAPAEEEPSSNEIHIGSLVIFPDAYVVSKRDETIELTH REFELLHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHPNW IVTRRGVGYYLRNPEQD*" /label="walR CDS" gene complement(3623986..3624693) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /label="walR gene" S_feature complement(3624694..3624790) /Source="Nicolas_S_feature" /locus_tag="new_4154404_4154500_c" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, dia0, LBGstat, dia5, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="1, 1, 0.11" /TUlongSig="SigA" /TUlongPSig="0.986" /label="S1552" promotor_-10 complement(3624778..3624797) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3624790) /Source="Nicolas_upshifts" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3624792..3624984) /Source="Nicolas_S_feature" /locus_tag="new_4154502_4154694_c" /HighExp="G180, Paraq, Oxctl, G135, G150, H2O2, T0.30H, BMM, Cold, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="0.986, 1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1553" promotor_-35 complement(3624813..3624816) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3624984) /Source="Nicolas_upshifts" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="upshifts" misc_feature complement(3624994..3625013) /Source="Nicolas_upshift_promotors" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3625076) /Source="Nicolas_upshifts" /id="D2090" /incds=0 /nref=8 /ntot=83 /MaxReadThrough="5.21091" /MaxDrop="5.81799" /score="24.1725164" /energy="-10.6" /TU="U3183,U3184" /idTUdmin="U3181" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" tRNA complement(3625077..3625149) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Phe tRNA" gene complement(3625077..3625149) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /label="trnY-Phe gene" tRNA complement(3625185..3625261) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Asp tRNA" gene complement(3625185..3625261) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /label="trnY-Asp gene" S_feature complement(3625262..3625342) /Source="Nicolas_S_feature" /locus_tag="new_4154972_4155052_c" /HighExp="Oxctl, Heat, BMM, Paraq, UNK1, H2O2, C30, MG 45, G180, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1554" tRNA complement(3625343..3625414) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Glu tRNA" gene complement(3625343..3625414) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /label="trnY-Glu gene" tRNA complement(3625424..3625499) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Lys tRNA" gene complement(3625424..3625499) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /label="trnY-Lys gene" misc_feature 3625471..3625487 /Source="Nicolas_upshift_promotors" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3625484 /Source="Nicolas_upshifts" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3625500..3625596) /Source="Nicolas_S_feature" /locus_tag="new_4155210_4155306_c" /HighExp="LBGstat, C30, UNK1, Oxctl, HPh, Heat, MG 150, BMM, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1555" promotor_-10 complement(3625580..3625599) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3625596) /Source="Nicolas_upshifts" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3625613..3625620) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(3625630..3625731) /Source="Nicolas_upshift_promotors" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3625670) /Source="Nicolas_upshifts" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3625724..3627016) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /EC_number="6.3.4.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1312531, 10368157, 16163456, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1312531, 10368157, 16163456, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate synthetase" /protein_id="NP_391922.1" /db_xref="EnsemblGenomes-Gn:BSU40420" /db_xref="EnsemblGenomes-Tr:CAB16079" /db_xref="GOA:P29726" /db_xref="InterPro:IPR001114" /db_xref="InterPro:IPR018220" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033128" /db_xref="SubtiList:BG10002" /db_xref="UniProtKB/Swiss-Prot:P29726" /translation="MSSVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGNNAGHTIK FDGITYKLHLIPSGIFYKDKTCVIGNGMVVDPKALVTELAYLHERNVSTDNLRISNRA HVILPYHLKLDEVEEERKGANKIGTTKKGIGPAYMDKAARIGIRIADLLDRDAFAEKL ERNLEEKNRLLEKMYETEGFKLEDILDEYYEYGQQIKKYVCDTSVVLNDALDEGRRVL FEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGSGVGPTKIKHVVGVSKAYTTRVGDGP FPTELKDEIGDQIREVGREYGTTTGRPRRVGWFDSVVVRHARRVSGITDLSLNSIDVL AGIETLKICVAYRYKGEIIEEFPASLKALAECEPVYEEMPGWTEDITGAKSLSELPEN ARHYLERVSQLTGIPLSIFSVGPDRSQTNVLRSVYRAN*" /label="purA CDS" gene complement(3625724..3627016) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /label="purA gene" downshifts complement(3625735) /Source="Nicolas_upshifts" /id="D2091" /incds=0 /nref=200 /ntot=241 /MaxReadThrough="2.03104" /MaxDrop="6.53551" /score="13.9967927" /energy="-10.5" /TU="NA" /idTUdmin="U3185" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3627056..3627075) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3627076) /Source="Nicolas_upshifts" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3627090..3627097) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3627222..3627641) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16731985" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391923.1" /db_xref="EnsemblGenomes-Gn:BSU40430" /db_xref="EnsemblGenomes-Tr:CAB16080" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:1TWU" /db_xref="SubtiList:BG10003" /db_xref="UniProtKB/Swiss-Prot:P37479" /translation="MGKRFSSFQAAQIRIARPTGQLDEIIRFYEEGLCLKRIGEFSQH NGYDGVMFGLPHADYHLEFTQYEGGSTAPVPHPDSLLVFYVPNAVELAAITSKLKHMG YQEVESENPYWSNGGVTIEDPDGWRIVFMNSKGISGK*" /label="yycE CDS" gene complement(3627222..3627641) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /label="yycE gene" promotor_-10 complement(3627639..3627650) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3627650) /Source="Nicolas_upshifts" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3627665..3627671) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3627762..3629126) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /EC_number="3.6.4.12" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="replicative DNA helicase" /protein_id="NP_391924.2" /db_xref="EnsemblGenomes-Gn:BSU40440" /db_xref="EnsemblGenomes-Tr:CAB16081" /db_xref="GOA:P37469" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR007692" /db_xref="InterPro:IPR007693" /db_xref="InterPro:IPR007694" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036185" /db_xref="SubtiList:BG10004" /db_xref="UniProtKB/Swiss-Prot:P37469" /translation="MTDLLNDRLPPQNIEAEQAVLGAIFLQPSALTLASEVLIPDDFY RMSHQKIYNAMLVLGDRGEPVDLVTVTSELANTDLLEEVGGISYLTDIANSVPTAANI EYYAKIVEEKSILRRLIRTATTIAQDGYTREDEVEDLLSEAEKTIMEVAQRKNTSAFQ NIKDVLVQTYDNIEQLHNRKGDITGIPTGFTELDRMTAGFQRNDLIIVAARPSVGKTA FALNIAQNVATKTDESVAIFSLEMGAEQLVMRMLCAEGNINAQNLRTGNLTEEDWGKL TMAMGSLSNSGIYIDDTPGIRVSEIRAKCRRLKQESGLGMILIDYLQLIQGSGRSKDN RQQEVSEISRELKSIARELQVPVIALSQLSRGVEQRQDKRPMMSDIRESGSIEQDADI VAFLYRDDYYDKETENKNIIEIIIAKQRNGPVGTVSLAFVKEYNKFVNLERRFDDAGV PPGA*" /label="dnaC CDS" gene complement(3627762..3629126) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /label="dnaC gene" downshifts complement(3627782) /Source="Nicolas_upshifts" /id="D2092" /incds=0 /nref=3 /ntot=107 /MaxReadThrough="1.37092" /MaxDrop="3.96365" /score="31.6981667" /energy="-12.6" /TU="NA" /idTUdmin="U3187" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3627826) /Source="Nicolas_upshifts" /id="D2093" /incds=1 /nref=9 /ntot=190 /MaxReadThrough="3.89737" /MaxDrop="3.21735" /score="31.6981667" /energy="-12.6" /TU="U3187" /idTUdmin="U3190" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3629157..3629176) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3629171) /Source="Nicolas_upshifts" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3629191..3629193) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3629238..3629244 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-35" promotor_-10 3629259..3629277 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-10" upshifts 3629261 /Source="Nicolas_upshifts" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="upshifts" CDS 3629296..3629496 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391925.1" /db_xref="EnsemblGenomes-Gn:BSU40450" /db_xref="EnsemblGenomes-Tr:CAB16082" /db_xref="InterPro:IPR018691" /db_xref="InterPro:IPR020086" /db_xref="SubtiList:BG10005" /db_xref="UniProtKB/Swiss-Prot:P37480" /translation="MIKKYAITPNVDADGWFIEVENVAPTALYTSKDAAIEKAKQVAK ENSPSKLVIYDQFKNVEEEHSF*" /label="yycD CDS" gene 3629296..3629496 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /label="yycD gene" downshifts 3629466 /Source="Nicolas_upshifts" /id="D2094" /incds=0 /nref=15 /ntot=43 /MaxReadThrough="4.45045" /MaxDrop="5.68737" /score="12.3008592" /energy="-9.5" /TU="U3188" /idTUdmin="U3188" /TUdmin="-352" /isTUend="FALSE" /label="downshifts" S_feature 3629511..3629832 /Source="Nicolas_S_feature" /locus_tag="new_4159220_4159541" /HighExp="Etha, C30, Salt, S6, S8, M9-stat, S7, Oxctl, Paraq, Heat" /AntisenseName="yyzB" /AntisenseCor="0.309580857935493" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1556" CDS complement(3629544..3629747) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391926.1" /db_xref="EnsemblGenomes-Gn:BSU40460" /db_xref="EnsemblGenomes-Tr:CAB16083" /db_xref="SubtiList:BG14171" /db_xref="UniProtKB/Swiss-Prot:O32296" /translation="MHAPLSLLKQMLKEHQIDTEKAVTFEEYIAMRLKLQELMGKFAS IGEWDLYQKAADLMMHIGIQWMK*" /label="yyzB CDS" gene complement(3629544..3629747) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /label="yyzB gene" S_feature complement(3629748..3630048) /Source="Nicolas_S_feature" /locus_tag="new_4159457_4159757_c" /HighExp="S6, S8, S7, S5, S4, BT, B36, T5.0H, S3, C30" /AntisenseName="yycC" /AntisenseCor="-0.77379453158709499" /AntisenseRegPval="-54.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.049" /TUlongSig="NA" /TUlongPSig="NA" /label="S1557" promotor_-35 3629813..3629816 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3629831..3629850 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3629834 /Source="Nicolas_upshifts" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="upshifts" CDS 3629868..3630008 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28546427" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391927.1" /db_xref="EnsemblGenomes-Gn:BSU40470" /db_xref="EnsemblGenomes-Tr:CAB16084" /db_xref="InterPro:IPR025550" /db_xref="SubtiList:BG10006" /db_xref="UniProtKB/Swiss-Prot:P37481" /translation="MRPLQISAETAQKLAESLNLPLEQIMHMPQHILLAKMAELQKED KS*" /label="yycC CDS" gene 3629868..3630008 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /label="yycC gene" S_feature 3630009..3630080 /Source="Nicolas_S_feature" /locus_tag="new_4159718_4159789" /HighExp="Sw, LoTm, Gly, BC, HiOs, B60, S0, T-5.40H, LBGstat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig=1 /label="S1558" upshifts complement(3630056) /Source="Nicolas_upshifts" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3630059..3630073) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3630081..3630085) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3630081..3631289 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25790494; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion ABC transporter (permease)" /protein_id="NP_391928.1" /db_xref="EnsemblGenomes-Gn:BSU40480" /db_xref="EnsemblGenomes-Tr:CAB16085" /db_xref="GOA:P37482" /db_xref="InterPro:IPR004747" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10007" /db_xref="UniProtKB/Swiss-Prot:P37482" /translation="MPHPHNKKIQSFWLITGIIFIAFNLRPAITSVGPVISSIRAELH MSNGAAGFLTALPLLSFAVLSPLAPKLGQRLGNERTLWLGLVILLIGVLTRSTGYTAA LFFGTALIGVGIAIGNVLLPSLIKHKYPEKPGIMISLYTTSMNIFAALASGVSVPLAT QMNGGWKQAFLLWGGLALLALLIWIPQLRHRDTANQTMKLQSSSIWASKMAWYVTIFM GLQSFLFYSSIAWFPEILRSHGIDTATAGWMVSLMQFASLPSTFLTPVLADRVKQQRG IVAALASVYLIGLCGLLAGGSHTLLAIWMIIIGIGQGSSISLALTLIGLRSENAQQAA ALSGMSQSFGYLLAAVGPIFVGYLFDQTHSWTMPIVLLIAALIVMGAAGQGAGRDRYI FQSEKQRNSA*" /label="yycB CDS" gene 3630081..3631289 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /label="yycB gene" downshifts 3631270 /Source="Nicolas_upshifts" /id="D2095" /incds=0 /nref=148 /ntot=242 /MaxReadThrough="3.65611" /MaxDrop="4.91246" /score="26.443484" /energy="-10.1" /TU="U3189" /idTUdmin="U3189" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS 3631394..3633451 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase" /protein_id="NP_391929.2" /db_xref="EnsemblGenomes-Gn:BSU40490" /db_xref="EnsemblGenomes-Tr:CAB16086" /db_xref="GOA:P37483" /db_xref="SubtiList:BG10008" /db_xref="UniProtKB/Swiss-Prot:P37483" /translation="MKTKRFDAALILILLAAAFLNTYHIWQDDTANQYYLAAVKSMTQ SFHNFFYASFDPSGFVTVDKPPVVLWIQTIFALIFGVHTWSVIIPQALAGVGSVFLLY RMVKPTFGVGAARIAALVMALTPIAVAVSRTNNIDSMLVFTLLLGSTCLLRAVKQGKL VWLLTAFALIGLAFNMKMMQAFMVLPAFVLFYLIASRVSLKKKIGSLLLSLVLLTGLS LSWAIAVDSASSSSRPYVGSSQTNSVLELAFGYNGTERLFGQTTGLAKGDMNAAGGGN MQNQDNMQAPNGNGSSFSQNGNQSFGNHSQAPQPPNGQTGALNGGGGTPPTGGNGPGN GGPGGGGGKSVNMFGTGDPGPLRLFQSALSGQISWMLPFSLIGLLGAIISWYRDRRGH AAKMKETLFWAAWLVPVAGFFSIAGFFHQYYLIMLAPPIAALSGIGWYTMHRLYKNNK DWSSYLLPAAVLITAVFQVYILSAYTSQIGSVWMYVLGLLGLGITLALLMLKRSHPFS KLLTIISLCVLLLTPVYWSATPLLYGGNSVLPESGPQLKGSANGGNMFSSEVDSGLLS YLRKHNTGEEYLFATLTTVTAAPYIIYENESVMAMGGFNGTDPILTVSELKKLIKEGK VKYFLLSENNSGNSELVSWIKKNGKEITSDEYSGSSSSTNSVQGMRRGPGGESQQTLY LVE*" /label="yycA CDS" gene 3631394..3633451 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /label="yycA gene" downshifts 3633316 /Source="Nicolas_upshifts" /id="D2096" /incds=1 /nref=43 /ntot=203 /MaxReadThrough="1.96363" /MaxDrop="3.65354" /score="19.8733078" /energy="-16.6" /TU="NA" /idTUdmin="U3189" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS complement(3633488..3633937) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 23002217; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L9" /protein_id="NP_391930.1" /db_xref="EnsemblGenomes-Gn:BSU40500" /db_xref="EnsemblGenomes-Tr:CAB16087" /db_xref="GOA:P37437" /db_xref="InterPro:IPR000244" /db_xref="InterPro:IPR009027" /db_xref="InterPro:IPR020069" /db_xref="InterPro:IPR020070" /db_xref="InterPro:IPR020594" /db_xref="InterPro:IPR036791" /db_xref="InterPro:IPR036935" /db_xref="SubtiList:BG10009" /db_xref="UniProtKB/Swiss-Prot:P37437" /translation="MKVIFLQDVKGKGKKGEVKNVADGYAHNFLIKKGLAVEANASNI SALNGQKQKEKKEAIAELEQAKSLKETLEKLTVELSAKSGEGGRLFGSVTSKQITEQL QKDHNIKVDKRKLELPDGIRALGYTNVPVKLHPEVQAVLKVHVKEEA*" /label="rplI CDS" gene complement(3633488..3633937) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /label="rplI gene" downshifts complement(3633502) /Source="Nicolas_upshifts" /id="D2097" /incds=0 /nref=231 /ntot=266 /MaxReadThrough="2.69721" /MaxDrop="6.57383" /score="44.1169256" /energy="-16.6" /TU="NA" /idTUdmin="U3191" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3633934..3635913) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /EC_number="3.1.4.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphodiesterase acting on cyclic dinucleotides" /protein_id="NP_391931.1" /db_xref="EnsemblGenomes-Gn:BSU40510" /db_xref="EnsemblGenomes-Tr:CAB16088" /db_xref="GOA:P37484" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR014528" /db_xref="SubtiList:BG10010" /db_xref="UniProtKB/Swiss-Prot:P37484" /translation="MPSFYEKPLFRYPIYALIALSIITILISFYFNWILGTVEVLLLA VILFFIKRADSLIRQEIDAYISTLSYRLKKVGEEALMEMPIGIMLFNDQYYIEWANPF LSSCFNESTLVGRSLYDTCESVVPLIKQEVESETVTLNDRKFRVVIKRDERLLYFFDV TEQIQIEKLYENERTVLAYIFLDNYDDVTQGLDDQTRSTMNSQVTSLLNAWAQEYGIF LKRTSSERFIAVLNEHILTELENSKFSILDEVREKTSFDGVALTLSVGVGASVSSLKE LGDLAQSSLDLALGRGGDQVAIKLPNGKVKFYGGKTNPMEKRTRVRARVISHALKEIV TESSNVIIMGHKFPDMDSIGAAIGILKVAQANNKDGFIVIDPNQIGSSVQRLIGEIKK YEELWSRFITPEEAMEISNDDTLLVIVDTHKPSLVMEERLVNKIEHIVVIDHHRRGEE FIRDPLLVYMEPYASSTAELVTELLEYQPKRLKINMIEATALLAGIIVDTKSFSLRTG SRTFDAASYLRAKGADTVLVQKFLKETVDSYIKRAKLIQHTVLYKDNIAIASLPENEE EYFDQVLIAQAADSLLSMSEVEASFAVARRDEQTVCISARSLGEVNVQIIMEALEGGG HLTNAATQLSGISVSEALERLKHAIDEYFEGGVQR*" /label="gdpP CDS" gene complement(3633934..3635913) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /label="gdpP gene" misc_feature complement(3634415..3634434) /Source="Nicolas_upshift_promotors" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3634418) /Source="Nicolas_upshifts" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3634831..3634838 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3634852..3634870 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3634856..3635522 /Source="Nicolas_S_feature" /locus_tag="new_4164565_4165231" /HighExp="LBGstat, C30, Cold, GM 10, GM 25, GM 15, GM-0.1, GM 45, GM 120, GM 90" /AntisenseName="yybT" /AntisenseCor="0.145393098609886" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1559" upshifts 3634856 /Source="Nicolas_upshifts" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3635950..3636879) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22956758; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391932.1" /db_xref="EnsemblGenomes-Gn:BSU40520" /db_xref="EnsemblGenomes-Tr:CAB16089" /db_xref="InterPro:IPR018710" /db_xref="SubtiList:BG10011" /db_xref="UniProtKB/Swiss-Prot:P37485" /translation="MKQTRALMEGAILISLFAIITLLVVYVPVIGTILLFALPLPMIL YTIRHGLKLGIWMGAVSLPVVFIVGSFNGLIVAFMSACAGIAMGHFFKRKEPGHAIIS GALIYMLSIVFYFVISIQFLGINIIDEAMTQYRQSLDIVETVAKQSGNAGQFEKQLKL MEEQLGIVQYLFPTAIVMVGVIFSFLSYLIAKPLLRRFSPDIPNLKPFRELKFPQSVV VLYLIIVMLSFLPLEKGQMLYSIALNGEFILGFLIFIQGLSFIFFYCHKKQYPKAAAV IAVILGFVHPVFMAAIRILGVLDMGFHIRNKVK*" /label="yybS CDS" gene complement(3635950..3636879) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /label="yybS gene" S_feature complement(3636880..3637016) /Source="Nicolas_S_feature" /locus_tag="new_4166589_4166725_c" /HighExp="H2O2, G150, G180, Cold, Paraq, G135, Oxctl, Salt, Etha, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1560" promotor_-10 complement(3636998..3637017) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3637016) /Source="Nicolas_upshifts" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3637032..3637037) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3637106..3637255) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097802.1" /db_xref="EnsemblGenomes-Gn:BSU40529" /db_xref="EnsemblGenomes-Tr:CAX52718" /db_xref="GOA:C0H3U2" /db_xref="UniProtKB/Swiss-Prot:C0H3U2" /translation="MWDMIKNFFLFSSGVLQATTLLLVILIFMYVRKTKKKNKESSGF MDDKH*" /label="yyzH CDS" gene complement(3637106..3637255) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /label="yyzH gene" downshifts complement(3637132) /Source="Nicolas_upshifts" /id="D2098" /incds=0 /nref=1 /ntot=44 /MaxReadThrough="6.98636" /MaxDrop="3.23568" /score="-6.7107279" /energy="-8.4" /TU="U3194" /idTUdmin="U3197" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3637294..3637313) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-10" upshifts complement(3637311) /Source="Nicolas_upshifts" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="upshifts" promotor_-35 complement(3637327..3637333) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-35" promotor_-35 3637334..3637343 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3637356..3637375 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3637362 /Source="Nicolas_upshifts" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3637374) /Source="Nicolas_upshifts" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3637376..3637889) /Source="Nicolas_S_feature" /locus_tag="new_4167085_4167598_c" /HighExp="dia5, Diami, H2O2, Salt, dia15, Etha, Paraq, LPhT, G180, C30" /AntisenseName="cotF" /AntisenseCor="-0.33406696665100499" /AntisenseRegPval="-7.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1561" promotor_-10 complement(3637378..3637392) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3637401..3637405) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3637401..3637883 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1708381, 19933362, 23335421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1708381, 19933362, 23335421; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_391933.1" /db_xref="EnsemblGenomes-Gn:BSU40530" /db_xref="EnsemblGenomes-Tr:CAB16090" /db_xref="GOA:P23261" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="InterPro:IPR016493" /db_xref="SubtiList:BG10012" /db_xref="UniProtKB/Swiss-Prot:P23261" /translation="MDERRTLAWHETLEMHELVAFQSNGLIKLKKMIREVKDPQLRQL YNVSIQGVEQNLRELLPFFPQAPHREDEEEERADNPFYSGDLLGFAKTSVRSYAIAIT ETATPQLRNVLVKQLNAAIQLHAQVYRYMYQHGYYPSYNLSELLKNDVRNANRAISMK *" /label="cotF CDS" gene 3637401..3637883 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /label="cotF gene" downshifts 3637870 /Source="Nicolas_upshifts" /id="D2099" /incds=0 /nref=20 /ntot=52 /MaxReadThrough="5.45774" /MaxDrop="4.1869" /score="-3.60126456" /energy="-16.9" /TU="U3195" /idTUdmin="U3195" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" CDS complement(3637913..3638290) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22238377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22238377; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Cys-activated by oxidative stress)" /protein_id="NP_391934.1" /db_xref="EnsemblGenomes-Gn:BSU40540" /db_xref="EnsemblGenomes-Tr:CAB16091" /db_xref="GOA:P37486" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4A5M" /db_xref="PDB:4A5N" /db_xref="SubtiList:BG10013" /db_xref="UniProtKB/Swiss-Prot:P37486" /translation="MSEKKNIYPNKEGCPVEFTLDVIGGKWKGILFYHMIDGKKRFNE FRRICPSITQRMLTLQLRELEADGIVHREVYHQVPPKVEYSLTEFGRTLEPIVLQMKE WGESNRDVLESYRSNGLVKDQQK*" /label="hypR CDS" gene complement(3637913..3638290) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /label="hypR gene" S_feature 3637915..3638444 /Source="Nicolas_S_feature" /locus_tag="new_4167624_4168153" /HighExp="S8, S6, S7, BT, S5, B36, C30, B60, G/S, Pyr" /AntisenseName="yybR" /AntisenseCor="-0.26586375565089998" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1562" downshifts complement(3637934) /Source="Nicolas_upshifts" /id="D2100" /incds=0 /nref=124 /ntot=240 /MaxReadThrough="4.32896" /MaxDrop="5.38963" /score="10.6464065" /energy="-15.3" /TU="U3197" /idTUdmin="U3197" /TUdmin="-802" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3638345..3638364) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3638357) /Source="Nicolas_upshifts" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3638378..3638385) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3638426..3638430 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3638444..3638463 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3638446 /Source="Nicolas_upshifts" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3638471..3638485) /Source="Nicolas_upshift_promotors" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3638474) /Source="Nicolas_upshifts" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3638495..3639424 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /EC_number="3.6.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic pyrophosphatase (Mn2+-dependent)" /protein_id="NP_391935.1" /db_xref="EnsemblGenomes-Gn:BSU40550" /db_xref="EnsemblGenomes-Tr:CAB16092" /db_xref="GOA:P37487" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR004097" /db_xref="InterPro:IPR022934" /db_xref="PDB:1K23" /db_xref="PDB:1WPM" /db_xref="PDB:1WPN" /db_xref="PDB:2HAW" /db_xref="PDB:2IW4" /db_xref="SubtiList:BG10014" /db_xref="UniProtKB/Swiss-Prot:P37487" /translation="MEKILIFGHQNPDTDTICSAIAYADLKNKLGFNAEPVRLGQVNG ETQYALDYFKQESPRLVETAANEVNGVILVDHNERQQSIKDIEEVQVLEVIDHHRIAN FETAEPLYYRAEPVGCTATILNKMYKENNVKIEKEIAGLMLSAIISDSLLFKSPTCTD QDVAAAKELAEIAGVDAEEYGLNMLKAGADLSKKTVEELISLDAKEFTLGSKKVEIAQ VNTVDIEDVKKRQAELEAVISKVVAEKNLDLFLLVITDILENDSLALAIGNEAAKVEK AFNVTLENNTALLKGVVSRKKQVVPVLTDAMAE*" /label="ppaC CDS" gene 3638495..3639424 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /label="ppaC gene" downshifts 3639410 /Source="Nicolas_upshifts" /id="D2101" /incds=0 /nref=235 /ntot=270 /MaxReadThrough="2.06965" /MaxDrop="8.02492" /score="25.8885382" /energy="-11.7" /TU="NA" /idTUdmin="U3195" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3639453) /Source="Nicolas_upshifts" /id="D2102" /incds=0 /nref=14 /ntot=136 /MaxReadThrough="1.08899" /MaxDrop="4.94065" /score="19.3488922" /energy="-11.7" /TU="NA" /idTUdmin="U3200" /TUdmin=33 /isTUend="FALSE" /label="downshifts" CDS complement(3639457..3639903) /gene="yybP" /locus_tag="BSU_40560" /old_locus_tag="BSU40560" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 25794618, 25794619; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative manganese-binding lipoprotein" /protein_id="NP_391936.1" /db_xref="EnsemblGenomes-Gn:BSU40560" /db_xref="EnsemblGenomes-Tr:CAB16093" /db_xref="GOA:P37488" /db_xref="SubtiList:BG10015" /db_xref="UniProtKB/Swiss-Prot:P37488" /translation="MKIILTVLAGVGLLSAGGCGMLDQVNDGLNYTSEAAGYVEKVKT FAEEAPELAEKAVNDTEAKEKLEAQLESIQKAAADFNELTPPDAAAEIHRTIQEHNET LQKSAEDVLKQAEEGKVSLKELEQSDLVQNAKQITDVMGQIEKLGE*" /label="yybP CDS" gene complement(3639457..3639903) /gene="yybP" /locus_tag="BSU_40560" /old_locus_tag="BSU40560" /label="yybP gene" S_feature complement(3639904..3640234) /Source="Nicolas_S_feature" /locus_tag="new_4169613_4169943_c" /HighExp="S8, Cold, S7, S6, H2O2, S5, S4, Etha, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998614" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1563" misc_RNA complement(3640093..3640210) /gene="mswM" /locus_tag="BSU_misc_RNA_94" /product="manganese ion binding riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" /label="mswM RNA" gene complement(3640093..3640210) /gene="mswM" /locus_tag="BSU_misc_RNA_94" /label="mswM gene" promotor_-10 complement(3640225..3640244) /Source="Nicolas_upshift_promotors" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3640233) /Source="Nicolas_upshifts" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3640258..3640265) /Source="Nicolas_upshift_promotors" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3640271..3640277 /Source="Nicolas_upshift_promotors" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3640290 /Source="Nicolas_upshifts" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3640292..3640310 /Source="Nicolas_upshift_promotors" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3640306..3640312 /Source="Nicolas_upshift_promotors" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3640327..3640338 /Source="Nicolas_upshift_promotors" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3640334 /Source="Nicolas_upshifts" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="upshifts" CDS 3640336..3641643 /gene="yybO" /locus_tag="BSU_40570" /old_locus_tag="BSU40570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_391937.1" /db_xref="EnsemblGenomes-Gn:BSU40570" /db_xref="EnsemblGenomes-Tr:CAB16094" /db_xref="GOA:P37489" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10016" /db_xref="UniProtKB/Swiss-Prot:P37489" /translation="MTEEVFIMSQERVKRPGHTRWYISSLLSGIIILNYFDRVAISVA APAIQDSFHLTATELGIVFSIYTYSYTLMQLPVGSLLDRFGVAWVTRVGMTIWSFLTI LLAFLQGKLLLYLFRFLIGLTSASAFPAASKATALWFPPSERGLANSLFDSAAKFSNV IGAPLVAFLVTTFDWRVAFLTIGCINVLFTIFFWQYYEQPERHKRISKSELNYIQKHN AITTEQIPYKTGPLLKKLFTNRKVWGLMIGFTGYGYTFNLLLTWLPTFFKHTYGMDLM SSGLFTAVPWLISTISGIAVGGWLVDYFIKKGYPNTKVYRTVIIVGMSFGFFFLGSIL TNNITVAIICISIGLAGISATAPVGWSISAELAPIGSVSMLSSMVNLANNLFGGIIAA SLTGYLFDVTGSFTLSFLVAGFVLLLGLVFYVFVLGDVKRIKL*" /label="yybO CDS" gene 3640336..3641643 /gene="yybO" /locus_tag="BSU_40570" /old_locus_tag="BSU40570" /label="yybO gene" downshifts complement(3641444) /Source="Nicolas_upshifts" /id="D2103" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="0.73662" /MaxDrop="2.97868" /score="30.543563" /energy="-17.9" /TU="NA" /idTUdmin="U3203" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 3641632 /Source="Nicolas_upshifts" /id="D2104" /incds=0 /nref=7 /ntot=55 /MaxReadThrough="2.76545" /MaxDrop="3.99898" /score="-3.44083304" /energy="-17.9" /TU="NA" /idTUdmin="U3201" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3641687..3641926) /gene="yyzI" /locus_tag="BSU_40573" /old_locus_tag="BSU40573" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52719.1" /translation="MNYKKQNQGFGSISGDHNDIHDILATIEENGTQDAFHYEGGLQG KNEQVLEQIEQEMLASGLDIEEQDEEKVNGDGPIL*" /label="yyzI CDS" gene complement(3641687..3641926) /gene="yyzI" /locus_tag="BSU_40573" /old_locus_tag="BSU40573" /pseudo /label="yyzI gene" downshifts complement(3641708) /Source="Nicolas_upshifts" /id="D2105" /incds=0 /nref=4 /ntot=114 /MaxReadThrough="3.05613" /MaxDrop="4.69729" /score="30.543563" /energy="-17.9" /TU="NA" /idTUdmin="U3203" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3641712..3641812) /Source="Nicolas_upshift_promotors" /id="U3203" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.552447552447552" /psig="0.010989010989011" /xcortree=1485 /SigmaFactorBS="gaaggtggtcttcaaggaaaaaacgagcaggtgctcgaacag atagagcaggaaatgctagcttcggggcttgatatagaggaacaggacgaggagaagg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3641752) /Source="Nicolas_upshifts" /id="U3203" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.552447552447552" /psig="0.010989010989011" /xcortree=1485 /SigmaFactorBS="gaaggtggtcttcaaggaaaaaacgagcaggtgctcgaacag atagagcaggaaatgctagcttcggggcttgatatagaggaacaggacgaggagaagg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3641916..3642080) /gene="yyzJ" /locus_tag="BSU_40574" /old_locus_tag="BSU40574" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52720.1" /translation="MMIRGIHLEQQLKDIISACDVAIQNEDFDTLMNYYSERIMCKPR KQPPQRFCEL*" /label="yyzJ CDS" gene complement(3641916..3642080) /gene="yyzJ" /locus_tag="BSU_40574" /old_locus_tag="BSU40574" /pseudo /label="yyzJ gene" CDS complement(3642092..3642277) /locus_tag="BSU_40576" /old_locus_tag="BSU40576" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514014.1" /translation="MSHQTKYPVNEAAIMPSNRLFARFTMELSMDTEPIGASSAEMDQ RNRKNKNEKDPYVSNIV*" /label="hypothetical protein CDS" gene complement(3642092..3642277) /locus_tag="BSU_40576" /old_locus_tag="BSU40576" /label="gene" downshifts 3642358 /Source="Nicolas_upshifts" /id="D2106" /incds=0 /nref=13 /ntot=90 /MaxReadThrough="0.18425" /MaxDrop="3.85413" /score="3.91893698" /energy="-13.7" /TU="NA" /idTUdmin="U3201" /TUdmin=726 /isTUend="FALSE" /label="downshifts" CDS complement(3642550..3642696) /gene="yyzK" /locus_tag="BSU_40578" /old_locus_tag="BSU40578" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52721.1" /translation="MYGKTIKKRLEKIAFLFQEISKKRKEKIERSFVGSKQLHGLSYR RFRG*" /label="yyzK CDS" gene complement(3642550..3642696) /gene="yyzK" /locus_tag="BSU_40578" /old_locus_tag="BSU40578" /pseudo /label="yyzK gene" CDS complement(3642678..3642827) /gene="yyzL" /locus_tag="BSU_40579" /old_locus_tag="BSU40579" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52722.1" /translation="MLNQHTLTYSTIDRKDYRSYKSNPEICLRILHKINETPESRYSV CMAKP*" /label="yyzL CDS" gene complement(3642678..3642827) /gene="yyzL" /locus_tag="BSU_40579" /old_locus_tag="BSU40579" /pseudo /label="yyzL gene" misc_feature complement(3643143..3643159) /Source="Nicolas_upshift_promotors" /id="U3204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.330669330669331" /psig="0.761238761238761" /xcortree=650 /SigmaFactorBS="agattaactatattatatcttaactgtaataacctgtaaaga attttattgatagtattggATTTTATGTTATAAAGGaaaaagggtgggcgatttgctc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3643160) /Source="Nicolas_upshifts" /id="U3204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.330669330669331" /psig="0.761238761238761" /xcortree=650 /SigmaFactorBS="agattaactatattatatcttaactgtaataacctgtaaaga attttattgatagtattggATTTTATGTTATAAAGGaaaaagggtgggcgatttgctc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3643179..3643186 /Source="Nicolas_upshift_promotors" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3643201..3643404 /Source="Nicolas_S_feature" /locus_tag="new_4172910_4173113" /HighExp="nit, T-3.40H, T-1.40H, T-0.40H, T0.0H, SMMPr, SMM, LoTm, ferm, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1564" promotor_-10 3643201..3643220 /Source="Nicolas_upshift_promotors" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3643201 /Source="Nicolas_upshifts" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3643222..3643236) /Source="Nicolas_upshift_promotors" /id="U3206" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=295 /SigmaFactorBS="tggggagatggagttactcctatttaaaacttcaacacaagt aataaaaaCCTCCTTTTACGTAAaagattaactatattatatcttaactgtaataacc t" /listShort="yyzL, yyzK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3643226) /Source="Nicolas_upshifts" /id="U3206" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=295 /SigmaFactorBS="tggggagatggagttactcctatttaaaacttcaacacaagt aataaaaaCCTCCTTTTACGTAAaagattaactatattatatcttaactgtaataacc t" /listShort="yyzL, yyzK" /GFF_Attribute="listLong" /label="upshifts" CDS 3643405..3643842 /gene="yybN" /locus_tag="BSU_40580" /old_locus_tag="BSU40580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27902860" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391938.1" /db_xref="EnsemblGenomes-Gn:BSU40580" /db_xref="EnsemblGenomes-Tr:CAB16095" /db_xref="InterPro:IPR020208" /db_xref="SubtiList:BG10017" /db_xref="UniProtKB/Swiss-Prot:P37490" /translation="MNKFLKSNFRFLLAAALGISLLASSNFIKASNDNYKFHLLVPYG YGNAYSNDAFRQTTHTDNPWKVNLQKSAEGKGTIMTFWLINTGNSKIPKASKIHNVKQ GSGAHYYHANSQGSHTYVALAVENNNYSASSYGIDGVWDEETW*" /label="yybN CDS" gene 3643405..3643842 /gene="yybN" /locus_tag="BSU_40580" /old_locus_tag="BSU40580" /label="yybN gene" S_feature 3643843..3643919 /Source="Nicolas_S_feature" /locus_tag="new_4173552_4173628" /HighExp="M9-tran, SMMPr, MG 120, aero, GM 120, SMM, T-2.40H, T-4.40H, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1565" downshifts 3643876 /Source="Nicolas_upshifts" /id="D2107" /incds=0 /nref=10 /ntot=98 /MaxReadThrough="6.91942" /MaxDrop="3.8662" /score="9.16494325" /energy="-9.5" /TU="U3205" /idTUdmin="U3201" /TUdmin=2244 /isTUend="FALSE" /label="downshifts" CDS 3643956..3644711 /gene="yybM" /locus_tag="BSU_40590" /old_locus_tag="BSU40590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391939.1" /db_xref="EnsemblGenomes-Gn:BSU40590" /db_xref="EnsemblGenomes-Tr:CAB16096" /db_xref="SubtiList:BG10018" /db_xref="UniProtKB/Swiss-Prot:P37491" /translation="MESHIYRIIKNKLTIIIFTIIILIPCVDISLLLMTNTEYHPAYA FFLSGTSVGHASQMILLWFLPLYFLLLCADDSIQDYKTGYHYILISKVGRKKYCLEKI FTSFIISFLTMFLSLILNFLLVQVFFFKGTFKNDLDQIKFPDNSLYTFSMAHPYIAIV LFSIICCIMSGFVGALGSSLSLLFRDKKYAYPASFFIWFVLILKNKSLMFLFQPFTEY GYNVLLPILCLSIFIFLIIISSIVLYEAKYNEN*" /label="yybM CDS" gene 3643956..3644711 /gene="yybM" /locus_tag="BSU_40590" /old_locus_tag="BSU40590" /label="yybM gene" S_feature complement(3644551..3647140) /Source="Nicolas_S_feature" /locus_tag="new_4174260_4176850_c" /HighExp="S8, S6, S4, S5, S7, S3, C30, BT, G135, T5.0H" /AntisenseName="yybK" /AntisenseCor="-0.46686696237140402" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1566" CDS 3644701..3645411 /gene="yybL" /locus_tag="BSU_40600" /old_locus_tag="BSU40600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391940.1" /db_xref="EnsemblGenomes-Gn:BSU40600" /db_xref="EnsemblGenomes-Tr:CAB16097" /db_xref="SubtiList:BG10019" /db_xref="UniProtKB/Swiss-Prot:P37492" /translation="MKIKRLLLILCLLLFLVTLWFNQNHTYLGKNSIASLLYMNNSTF GYSSIFAYTLFYIVPFLMLLSNFFHSENPYKVMRMVKRKNYYKSKIMEIGFVSLLFSS IHTVINITCTHIFFSKNLLVEANFLSICLLNMISLVFFYLSVGIMFRLTYDLFNSVAL AIFIVYIILDSLYFGVKLLLPNGYWEPFRDLAIFTNMLNRYWSTSNLIIVYIRQIIIV FIFYLVGSSIFLNKDYKK*" /label="yybL CDS" gene 3644701..3645411 /gene="yybL" /locus_tag="BSU_40600" /old_locus_tag="BSU40600" /label="yybL gene" downshifts 3644910 /Source="Nicolas_upshifts" /id="D2108" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="7.39982" /MaxDrop="2.95139" /score="9.16494325" /energy="-9.5" /TU="U3205" /idTUdmin="U3205" /TUdmin="-2354" /isTUend="FALSE" /label="downshifts" CDS 3645408..3646163 /gene="yybK" /locus_tag="BSU_40610" /old_locus_tag="BSU40610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391941.1" /db_xref="EnsemblGenomes-Gn:BSU40610" /db_xref="EnsemblGenomes-Tr:CAB16098" /db_xref="InterPro:IPR024295" /db_xref="SubtiList:BG10020" /db_xref="UniProtKB/Swiss-Prot:P37493" /translation="MRIKGFFITLVAIIFQASLSSYNNNKNVFPFLDGIPISTSGHYE YQNILLWFVPIVSLSFCFSGSIRDTYISYEQLKLVREHSRVKWVTSQFLIITVVLLIF TLSQIAIFYIYSLVSLHNLDINSVINKRFVMMTLMYYLTLLNLFSFQLFMELYYKSQI AQLNISVYIIFSLILAKKLVQLNSPKVIHYFLIPNYSNGLRTGLSYYSQSGTAIIEPL LGLFIIIILQISIVILSVLKFKKIDMLKSEGLQ*" /label="yybK CDS" gene 3645408..3646163 /gene="yybK" /locus_tag="BSU_40610" /old_locus_tag="BSU40610" /label="yybK gene" CDS 3646160..3646815 /gene="yybJ" /locus_tag="BSU_40620" /old_locus_tag="BSU40620" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1938973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-binding cassette subunit of transporter" /protein_id="NP_391942.1" /db_xref="EnsemblGenomes-Gn:BSU40620" /db_xref="EnsemblGenomes-Tr:CAB16099" /db_xref="GOA:P37494" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10021" /db_xref="UniProtKB/Swiss-Prot:P37494" /translation="MIEVLNLTKKLKRLQF*IISLIHLKKEQFMDYLGVMVLERPCYF VHYPG**SLLKGV*LLKVNNYIKISLFLKV*D*L*KICSYFLSMMLLLTLKFCQKLKR SHQIMIY*ILLVELVWKILIV*RLVNSR*E*NND*ILHRLFLKNLIYCYLMNQQMRLM KKELHLFMTFFYKRKKGELPLLLLVITRKILYLYVTLH*K*IMDV*KLQKK*YIRKIV " /label="yybJ CDS" gene 3646160..3646815 /gene="yybJ" /locus_tag="BSU_40620" /old_locus_tag="BSU40620" /label="yybJ gene" S_feature 3646816..3647130 /Source="Nicolas_S_feature" /locus_tag="new_4176526_4176840" /HighExp="aero, Cold, HPh, nit, M/G, M9-tran, S1, SMM, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1567" downshifts 3647087 /Source="Nicolas_upshifts" /id="D2109" /incds=0 /nref=93 /ntot=227 /MaxReadThrough="3.45614" /MaxDrop="4.54398" /score="2.19825508" /energy="-10.3" /TU="U3205" /idTUdmin="U3205" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 3647131 /Source="Nicolas_upshifts" /id="D2110" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.98662" /MaxDrop="3.29879" /score="2.19825508" /energy="-10.3" /TU="U3205" /idTUdmin="U3205" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts complement(3647185) /Source="Nicolas_upshifts" /id="D2111" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.53364" /MaxDrop="2.25148" /score="10.1219981" /energy="-6.3" /TU="U3207" /idTUdmin="U3209" /TUdmin=2266 /isTUend="FALSE" /label="downshifts" CDS complement(3647190..3647978) /gene="ictI" /locus_tag="BSU_40630" /old_locus_tag="BSU40630" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16321932, 22882546, 25835496" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932, 22882546, 25835496; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391943.1" /db_xref="EnsemblGenomes-Gn:BSU40630" /db_xref="EnsemblGenomes-Tr:CAB16100" /db_xref="SubtiList:BG10022" /db_xref="UniProtKB/Swiss-Prot:P37495" /translation="MNVYDIRMAPYWFYEGRGLVQHPYVFRQPVSSRAIIVSTRGDVT GDGVIDEVFLTGNQMPGSPLWRNITLVIRDGRTHQEQRIQLQNNMGYNPSLFLGDMTG DKIEDVAVVMDTGGSGGAIYAYVFAYLNRQFRRIFNSDVLNDELKYSVRYQNQYKASV ISHQQNETYILDLTYKGREYLNEIYNSQGVLKMPIEGWVNPLSGLYPVDFDRDGVYEL LAYQRIAGRYNADSLGYVQTVLKWNGQRFMFNRQTVTIFGSDLS*" /label="ictI CDS" gene complement(3647190..3647978) /gene="ictI" /locus_tag="BSU_40630" /old_locus_tag="BSU40630" /label="ictI gene" promotor_-10 complement(3648002..3648020) /Source="Nicolas_upshift_promotors" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3648021) /Source="Nicolas_upshifts" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3648036..3648041) /Source="Nicolas_upshift_promotors" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3648046..3648435) /gene="yybH" /locus_tag="BSU_40640" /old_locus_tag="BSU40640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391944.1" /db_xref="EnsemblGenomes-Gn:BSU40640" /db_xref="EnsemblGenomes-Tr:CAB16101" /db_xref="InterPro:IPR009959" /db_xref="InterPro:IPR032710" /db_xref="PDB:2GXF" /db_xref="SubtiList:BG10023" /db_xref="UniProtKB/Swiss-Prot:P37496" /translation="MEQQLKDIISACDLAIQNEDFDTLMNYYSEDAVLVVKPGMIARG KEEIKKAFITIANYFNHHIVPTQGKMILLEAGDTVLVLSQTLLDSDKKDSEYAMERRA TYVFKKNAQGEWLCVIDNSYGTDLIGV*" /label="yybH CDS" gene complement(3648046..3648435) /gene="yybH" /locus_tag="BSU_40640" /old_locus_tag="BSU40640" /label="yybH gene" promotor_-35 3648504..3648507 /Source="Nicolas_upshift_promotors" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3648522..3648541 /Source="Nicolas_upshift_promotors" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3648535 /Source="Nicolas_upshifts" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="upshifts" CDS 3648581..3649420 /gene="yybG" /locus_tag="BSU_40650" /old_locus_tag="BSU40650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11709313, 12486061" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391945.1" /db_xref="EnsemblGenomes-Gn:BSU40650" /db_xref="EnsemblGenomes-Tr:CAB16102" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG10024" /db_xref="UniProtKB/Swiss-Prot:P37497" /translation="MSAEVTLHDNIHYDLSADCQHCFGLCCVALPYAKSADFAFDKDG GTPCRNLQSNYQCSIHKDLREKGFRGCSAYECFGAGQKVSQITYEGKDWRNSPETANQ MFDVFPIMQQLHEMLWYLHEALSIDIAKPIHSELRTTFEKIERLTRLSKERLLTLQVD EHRAEVNEWLLKTSELVRAQARHPKLPKKVSRGSVLIGAKLKGLDLRGANLRGALLIA ADLRNADLRMTDFIGADMRDADLSGADLTGSIFLTQAQVNAANGDSNTKLPLSVRTPA HWK*" /label="yybG CDS" gene 3648581..3649420 /gene="yybG" /locus_tag="BSU_40650" /old_locus_tag="BSU40650" /label="yybG gene" downshifts 3649397 /Source="Nicolas_upshifts" /id="D2112" /incds=0 /nref=35 /ntot=188 /MaxReadThrough="1.19247" /MaxDrop="3.72166" /score="-0.156630814" /energy="-6.3" /TU="NA" /idTUdmin="U3208" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3649453..3650667) /gene="yybF" /locus_tag="BSU_40660" /old_locus_tag="BSU40660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811656, 11557812, 12486061, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_391946.1" /db_xref="EnsemblGenomes-Gn:BSU40660" /db_xref="EnsemblGenomes-Tr:CAB16103" /db_xref="GOA:P37498" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10025" /db_xref="UniProtKB/Swiss-Prot:P37498" /translation="MTYIRKGTPVFRKITFAFFAAGFNTFAILYCVQPLMEEFTREFH VTPTAASLSLSVTTMLLAVSMLVFGSLSEVWGRKPIMGISMLAASVLCLASAFSPSFH TLLVLRTIQGVALAGLPSIAMAYLGEEIEPGSLGSAMGLYISGNAIGAVFGRIVSGLL SEYLNWHMAMGTIGVISLIASVIFFINLPPSRHFTPRKLKLGKLGMSLIGHLRDRKLF SLFLIGFLLLGSNVALFNYIVYVLLGPPYSLNKAFSSWIFIVMIVGIFSSSFIGRMVD RYGYPKILVMNIFIVIAGALFTINNMLAVKILGIALFTFGFFGGHSVASSWVGRRALH NKAQASSLYLFFYYAGSSVFGTIGGLFWSGFHWLGVVGMITFMLLVALWLSGYLARSV KMPDKRNEKGLN*" /label="yybF CDS" gene complement(3649453..3650667) /gene="yybF" /locus_tag="BSU_40660" /old_locus_tag="BSU40660" /label="yybF gene" downshifts complement(3649471) /Source="Nicolas_upshifts" /id="D2113" /incds=0 /nref=45 /ntot=169 /MaxReadThrough="1.92237" /MaxDrop="5.70619" /score="10.1219981" /energy="-6.3" /TU="NA" /idTUdmin="U3209" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(3650668..3650771) /Source="Nicolas_S_feature" /locus_tag="new_4180378_4180481_c" /HighExp="BI, B60, ferm, T0.30H, T-1.10H, T-0.40H, T-1.40H, T1.0H, nit, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.94819299999999995" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1568" promotor_-10 complement(3650764..3650783) /Source="Nicolas_upshift_promotors" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3650772..3650779 /Source="Nicolas_upshift_promotors" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3650774) /Source="Nicolas_upshifts" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3650793..3650812 /Source="Nicolas_upshift_promotors" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3650797..3650804) /Source="Nicolas_upshift_promotors" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3650805 /Source="Nicolas_upshifts" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="upshifts" CDS 3650854..3651732 /gene="yybE" /locus_tag="BSU_40670" /old_locus_tag="BSU40670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591, 17526699, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391947.2" /db_xref="EnsemblGenomes-Gn:BSU40670" /db_xref="EnsemblGenomes-Tr:CAB16104" /db_xref="GOA:P37499" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10026" /db_xref="UniProtKB/Swiss-Prot:P37499" /translation="MEWEQLEYFQTLARMQHVTKAAKSLSITQPALSRSIARLENHLG VPLFDRQGRSISLNQYGHIFLRRVQAMMKEYTEGKEEIQALLKPDQGVVSLGFLHTLG TTLVPDLIGSFQQEYPNISFQLKQNHSYWLLERLKSGDLDLCLLASIKPENPIQWIKL WSEELFVFVPNDHPLASRESITLNEIAGERFILLKKGYALRMTVDELFEKANIQPNIM FEGEEATTAAGFVAAGLGISILPDLKGLDQSKITKIRVSWPECQRVIGIAWIKGRFLS PVAETFKQYVISHFSE*" /label="yybE CDS" gene 3650854..3651732 /gene="yybE" /locus_tag="BSU_40670" /old_locus_tag="BSU40670" /label="yybE gene" CDS 3651746..3652189 /gene="yybD" /locus_tag="BSU_40680" /old_locus_tag="BSU40680" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_391948.1" /db_xref="EnsemblGenomes-Gn:BSU40680" /db_xref="EnsemblGenomes-Tr:CAB16105" /db_xref="GOA:P37500" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10027" /db_xref="UniProtKB/Swiss-Prot:P37500" /translation="MNVKKITSEQDLHTAFEIRKAVFVEEQGCPISDEFDEFDTLHGD CQHILAYHQNVPVGTARVRIVGHTGKLERICILKSYRKFGLGKVIVDALERIVKEQGI SAFKLHGQTQAAGFYEKLGYRTASEEFMLDGIPHVLMTKQDDSAL*" /label="yybD CDS" gene 3651746..3652189 /gene="yybD" /locus_tag="BSU_40680" /old_locus_tag="BSU40680" /label="yybD gene" CDS 3652272..3652751 /gene="yybC" /locus_tag="BSU_40690" /old_locus_tag="BSU40690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28032445; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391949.1" /db_xref="EnsemblGenomes-Gn:BSU40690" /db_xref="EnsemblGenomes-Tr:CAB16106" /db_xref="SubtiList:BG10028" /db_xref="UniProtKB/Swiss-Prot:P37501" /translation="MPANKKEGLIFGVMMCFGMVCVMSIYNAIINRAIYDFSLMTVFE MVIGFMIALLLDLLLVGPLAKKIAFRMPFDKTKKIYVILAMSTCMVIGMVLCMSVFGL VTAVLANGLNGDSLFSAYLMIVLKNFILAYPLQLLIMGPLVRGVFMKFVKPKLTAAI* " /label="yybC CDS" gene 3652272..3652751 /gene="yybC" /locus_tag="BSU_40690" /old_locus_tag="BSU40690" /label="yybC gene" downshifts 3652741 /Source="Nicolas_upshifts" /id="D2114" /incds=0 /nref=13 /ntot=97 /MaxReadThrough="0.69144" /MaxDrop="3.55998" /score="-9.53342462" /energy="-10.9" /TU="NA" /idTUdmin="U3210" /TUdmin=1628 /isTUend="FALSE" /label="downshifts" CDS complement(3652926..3653588) /gene="yybB" /locus_tag="BSU_40700" /old_locus_tag="BSU40700" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391950.1" /db_xref="EnsemblGenomes-Gn:BSU40700" /db_xref="EnsemblGenomes-Tr:CAB16107" /db_xref="GOA:P37502" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10029" /db_xref="UniProtKB/Swiss-Prot:P37502" /translation="MNLRQLSEHVFQCEFELDVPLRIPVHTWFIKDGDDVYIVDTGIE RFADAQIRAALAIGNPKAILLTHGHSDHIGGASKWLERFDIPIFAHQKELKYINGEEP YPNKNEVENTGVAHIVQPLTEQTLAHLPLKYYLTPGHSPGHVVYYHKIDRTLLTGDLF ITSKEDLHPPIRRFSVDINENIDSGSIIDQIKPTLICSSHGEEILYNEELYKNYVVRY RD*" /label="yybB CDS" gene complement(3652926..3653588) /gene="yybB" /locus_tag="BSU_40700" /old_locus_tag="BSU40700" /label="yybB gene" CDS complement(3653735..3654187) /gene="yybA" /locus_tag="BSU_40710" /old_locus_tag="BSU40710" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, polyamine export and degradation)" /protein_id="NP_391951.1" /db_xref="EnsemblGenomes-Gn:BSU40710" /db_xref="EnsemblGenomes-Tr:CAB16108" /db_xref="GOA:P37503" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10030" /db_xref="UniProtKB/Swiss-Prot:P37503" /translation="MNDILREIGMIARALDSISNIEFKDLDLTRGQYLYLVRIYENPG IIQEKLAEMIKVDRTTAARAIKKLEMQGFIQKLPDEQNKKIKKLFPTEKGKKVYPLLR REGEHSTEVALSGFTSEEKETISALLHRVRKNIERDWEYVKKGNKRDY*" /label="yybA CDS" gene complement(3653735..3654187) /gene="yybA" /locus_tag="BSU_40710" /old_locus_tag="BSU40710" /label="yybA gene" promotor_-35 3654211..3654218 /Source="Nicolas_upshift_promotors" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3654233..3654252 /Source="Nicolas_upshift_promotors" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3654235 /Source="Nicolas_upshifts" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="upshifts" S_feature 3654237..3654306 /Source="Nicolas_S_feature" /locus_tag="new_4183947_4184016" /HighExp="G135, G180, H2O2, LoTm, G150, Salt, Diami, Paraq, LBGstat, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1569" promotor_-10 complement(3654240..3654259) /Source="Nicolas_upshift_promotors" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3654242) /Source="Nicolas_upshifts" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3654272..3654279) /Source="Nicolas_upshift_promotors" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3654307..3654753 /gene="yyaT" /locus_tag="BSU_40720" /old_locus_tag="BSU40720" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase (polyamine degradation)" /protein_id="NP_391952.1" /db_xref="EnsemblGenomes-Gn:BSU40720" /db_xref="EnsemblGenomes-Tr:CAB16109" /db_xref="GOA:P37504" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10031" /db_xref="UniProtKB/Swiss-Prot:P37504" /translation="MNIKRITTEADLHEALKIRRGVFIEEQHVSEADEFDEFDTLQEQ CQHILVYHENQPVGTGRARIVGHTAKLERICILKPYRKYGLGKIIVSGLEEIMKEKGL TSYKLHGQTQAAGFYQKLGYQISSQEFMEDGIPHVLMTKEISRNIT*" /label="yyaT CDS" gene 3654307..3654753 /gene="yyaT" /locus_tag="BSU_40720" /old_locus_tag="BSU40720" /label="yyaT gene" CDS 3654750..3655355 /gene="yyaS" /locus_tag="BSU_40730" /old_locus_tag="BSU40730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391953.1" /db_xref="EnsemblGenomes-Gn:BSU40730" /db_xref="EnsemblGenomes-Tr:CAB16110" /db_xref="SubtiList:BG10032" /db_xref="UniProtKB/Swiss-Prot:P37505" /translation="MKYMYYGIGILILSLGISLTIQSGLGTSPFDALLVGLSKKIGLT VGSWEVLISVILLICNAILTRKKPILLGLITAFITGIGIDLWLFVVKNTIYLNSLLSK LICFGIGLVLIGLGTAIYLQTKFASTPIDHLTLIIRDLSKRTILFSRTLVYALFLVLA IIFKGPIGIGTLLTVCLGGMLLHVFMPIVERHFLSKNRRGY*" /label="yyaS CDS" gene 3654750..3655355 /gene="yyaS" /locus_tag="BSU_40730" /old_locus_tag="BSU40730" /label="yyaS gene" CDS complement(3655450..3655971) /gene="yyaR" /locus_tag="BSU_40740" /old_locus_tag="BSU40740" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16579456, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyl-transferase" /protein_id="NP_391954.1" /db_xref="EnsemblGenomes-Gn:BSU40740" /db_xref="EnsemblGenomes-Tr:CAB16111" /db_xref="GOA:P37506" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR008125" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10033" /db_xref="UniProtKB/Swiss-Prot:P37506" /translation="MIMKMTHLNMKDFNKPNEPFVVFGRMIPAFENGVWTYTEERFSK PYFKQYEDDDMDVSYVEEEGKAAFLYYLENNCIGRIKIRSNWNGYALIEDIAVAKDYR KKGVGTALLHKAIEWAKENHFCGLMLETQDINISACHFYAKHHFIIGAVDTMLYSNFP TANEIAIFWYYKF*" /label="yyaR CDS" gene complement(3655450..3655971) /gene="yyaR" /locus_tag="BSU_40740" /old_locus_tag="BSU40740" /label="yyaR gene" S_feature complement(3655972..3656799) /Source="Nicolas_S_feature" /locus_tag="new_4185682_4186509_c" /HighExp="T0.30H, Lbstat, H2O2, LPhT, T1.0H, dia15, Diami, T1.30H, dia5, M9-stat" /AntisenseName="yyaQ" /AntisenseCor="0.51412050904654805" /AntisenseRegPval="-18.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1570" promotor_-35 3656020..3656027 /Source="Nicolas_upshift_promotors" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3656041 /Source="Nicolas_upshifts" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3656042..3656061 /Source="Nicolas_upshift_promotors" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3656107..3656381 /Source="Nicolas_S_feature" /locus_tag="new_4185817_4186091" /HighExp="LBGstat, G135, BC, G180, Sw, M9-stat, Diami, T0.30H, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13713" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1571" upshifts 3656107 /Source="Nicolas_upshifts" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3656110..3656115 /Source="Nicolas_upshift_promotors" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3656128..3656147 /Source="Nicolas_upshift_promotors" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3656382..3656738 /gene="yyaQ" /locus_tag="BSU_40750" /old_locus_tag="BSU40750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391955.1" /db_xref="EnsemblGenomes-Gn:BSU40750" /db_xref="EnsemblGenomes-Tr:CAB16112" /db_xref="InterPro:IPR007351" /db_xref="SubtiList:BG10034" /db_xref="UniProtKB/Swiss-Prot:P37507" /translation="MLTREDIFKHVKEKYGTSPDYPWEKYPNYASLRHTSNKKWYGLI MNVLPEKLGLDGHGEIDILNLKCPPEISDRLRNGENILPGYHMDKEHWISIVLERTDP EGEIYNLIEQSFHLTK*" /label="yyaQ CDS" gene 3656382..3656738 /gene="yyaQ" /locus_tag="BSU_40750" /old_locus_tag="BSU40750" /label="yyaQ gene" S_feature 3656739..3656897 /Source="Nicolas_S_feature" /locus_tag="new_4186449_4186607" /HighExp="Sw, BC, G135, H2O2, LBGstat, G180, LPhT, T0.30H, Diami, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1572" promotor_-10 complement(3656781..3656800) /Source="Nicolas_upshift_promotors" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3656799) /Source="Nicolas_upshifts" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3656815..3656822) /Source="Nicolas_upshift_promotors" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3656898..3657464 /gene="yyaP" /locus_tag="BSU_40760" /old_locus_tag="BSU40760" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391956.1" /db_xref="EnsemblGenomes-Gn:BSU40760" /db_xref="EnsemblGenomes-Tr:CAB16113" /db_xref="GOA:P37508" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="PDB:2GD9" /db_xref="SubtiList:BG10035" /db_xref="UniProtKB/Swiss-Prot:P37508" /translation="MTNNLKQRRIILDLAVTLDGFIEGKNGEVDWCIMDPDMGFTDFL NQIDTILYGRKSFDLWGQYIPKNEDPDTEKELWKLVHSKKKYVFSRTQNEIDNQAIFI NDNILEEVNKLKKNPGKDIWLYGGASLITTFINLGLVDEFRLSIHPVVLGEGKPLFID VKQRINLKMVNTRTFSSGVVQIVYHWNG*" /label="yyaP CDS" gene 3656898..3657464 /gene="yyaP" /locus_tag="BSU_40760" /old_locus_tag="BSU40760" /label="yyaP gene" CDS complement(3657971..3659347) /gene="tetB" /locus_tag="BSU_40770" /old_locus_tag="BSU40770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7961647, 14636065, 15849754, 16850406, 17015648, 25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7961647, 14636065, 15849754, 16850406, 17015648, 25954268; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multifunctional tetracycline-metal/H+ antiporterand Na+(K+)/H+ antiporter" /protein_id="NP_391957.1" /db_xref="EnsemblGenomes-Gn:BSU40770" /db_xref="EnsemblGenomes-Tr:CAB16114" /db_xref="GOA:P23054" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10036" /db_xref="UniProtKB/Swiss-Prot:P23054" /translation="MNTSYSQSTLRHNQVLIWLCVLSFFSVLNEMVLNVSLPDIANEF NKLPASANWVNTAFMLTFSIGTALYGKLSDQLGIKNLLLFGIMVNGLGSIIGFVGHSF FPILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGG MVAHYIHWSYLLLIPTATIITVPFLIKLLKKEERIRGHIDMAGIILMSAGIVFFMLFT TSYRFSFLIISILAFFIFVQHIRKAQDPFVDPELGKNVFFVIGTLCGGLIFGTVAGFV SMVPYMMKDVHHLSTAAIGSGIIFPGTMSVIIFGYIGGLLVDRKGSLYVLTIGSALLS SGFLIAAFFIDAAPWIMTIIVIFVFGGLSFTKTVISTVVSSSLKEKEAGAGMSLLNFT SFLSEGTGIAIVGGLLSIGFLDHRLLPIDVDHSTYLYSNMLILFAGIIVICWLVILNV YKRSRRHG*" /label="tetB CDS" gene complement(3657971..3659347) /gene="tetB" /locus_tag="BSU_40770" /old_locus_tag="BSU40770" /label="tetB gene" CDS complement(3659381..3659443) /gene="tetL" /locus_tag="BSU_40780" /old_locus_tag="BSU40780" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14636065, 17015648" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636065, 17015648; Product type t: transporter" /codon_start=1 /transl_table=11 /product="tetracycline resistance leader peptide" /protein_id="NP_391958.1" /db_xref="EnsemblGenomes-Gn:BSU40780" /db_xref="EnsemblGenomes-Tr:CAB16115" /db_xref="GOA:P23053" /db_xref="InterPro:IPR012618" /db_xref="SubtiList:BG11051" /db_xref="UniProtKB/Swiss-Prot:P23053" /translation="MKCNKMNRVQLKEGSVSMTL*" /label="tetL CDS" gene complement(3659381..3659443) /gene="tetL" /locus_tag="BSU_40780" /old_locus_tag="BSU40780" /label="tetL gene" promotor_-10 complement(3659464..3659483) /Source="Nicolas_upshift_promotors" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3659483) /Source="Nicolas_upshifts" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3659496..3659503) /Source="Nicolas_upshift_promotors" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3659631..3659637 /Source="Nicolas_upshift_promotors" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3659653..3659672 /Source="Nicolas_upshift_promotors" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3659659 /Source="Nicolas_upshifts" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="upshifts" CDS 3659696..3659935 /gene="yyaO" /locus_tag="BSU_40790" /old_locus_tag="BSU40790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391959.1" /db_xref="EnsemblGenomes-Gn:BSU40790" /db_xref="EnsemblGenomes-Tr:CAB16116" /db_xref="InterPro:IPR004879" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10037" /db_xref="UniProtKB/Swiss-Prot:P37509" /translation="MPNKSKPNRLIAEKSPYLLQHAHNPVDWFPWGEEAFAKAKRENK PVLVSIGYSTTCHWWPGIIKSCGTPLKDNRSHFKR*" /label="yyaO CDS" gene 3659696..3659935 /gene="yyaO" /locus_tag="BSU_40790" /old_locus_tag="BSU40790" /label="yyaO gene" downshifts 3659944 /Source="Nicolas_upshifts" /id="D2115" /incds=0 /nref=7 /ntot=103 /MaxReadThrough="1.03879" /MaxDrop="3.89186" /score="10.758481" /energy="-8.2" /TU="NA" /idTUdmin="U3217" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 3660028..3660035 /Source="Nicolas_upshift_promotors" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3660051..3660070 /Source="Nicolas_upshift_promotors" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3660067 /Source="Nicolas_upshifts" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="upshifts" CDS 3660086..3660502 /gene="yyaN" /locus_tag="BSU_40800" /old_locus_tag="BSU40800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948146, 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MerR family)" /protein_id="NP_391960.1" /db_xref="EnsemblGenomes-Gn:BSU40800" /db_xref="EnsemblGenomes-Tr:CAB16117" /db_xref="GOA:P37510" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG10038" /db_xref="UniProtKB/Swiss-Prot:P37510" /translation="MLLYSISKAAEKTSISSYTLRYYEKIGLLPPPKRKNSGRRFYTE TDIQFMLFLKSLKETGMSLEDINEFVKDGCILEKINSDVKSAQLSPSINKRIEILTKH LEKMEIKKRELEEVISTTKGKLDTYYSILKEEVENK*" /label="yyaN CDS" gene 3660086..3660502 /gene="yyaN" /locus_tag="BSU_40800" /old_locus_tag="BSU40800" /label="yyaN gene" CDS 3660499..3661416 /gene="yyaM" /locus_tag="BSU_40810" /old_locus_tag="BSU40810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391961.1" /db_xref="EnsemblGenomes-Gn:BSU40810" /db_xref="EnsemblGenomes-Tr:CAB16118" /db_xref="GOA:P37511" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10039" /db_xref="UniProtKB/Swiss-Prot:P37511" /translation="MKHLNIYIMLLGFSIFTGATFNLAKYTVGYFSPSSSAAWRFGLA AAVMLIILIFTEGIKKSQLRKNAVSYIVLGIIGIFGFNALFFVGLKYTSPVNGALIMG LNPLLTAILARIILKDNMTKKQVLGIFFAFIGVLLVITQGSIETIKTLSISGGDLIIF TGNVCWALYGVLGRRFVKDGTPLSTTTYTMVIGAVSLIVVSLFTSKPVSLSNIPIGVW GAIAFMAFFTSVLGYLWWNQGIKEIGASKTSLFFNLVPVVTMIISFAVGTPIKVFQVI GAVLVILGVLTASGVIRIPKYNTKEQSAI*" /label="yyaM CDS" gene 3660499..3661416 /gene="yyaM" /locus_tag="BSU_40810" /old_locus_tag="BSU40810" /label="yyaM gene" misc_feature 3661443..3661462 /Source="Nicolas_upshift_promotors" /id="U3219" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig="0.984015984015984" /xcortree=1462 /SigmaFactorBS="actaaagaacagtcagctatataaagaaatagggagtatttt tgagaaaaTGTGTTAAGTTAAATATACActaattataggaagaaggtgatcccatgcc a" /listShort="yyaL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3661453 /Source="Nicolas_upshifts" /id="U3219" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig="0.984015984015984" /xcortree=1462 /SigmaFactorBS="actaaagaacagtcagctatataaagaaatagggagtatttt tgagaaaaTGTGTTAAGTTAAATATACActaattataggaagaaggtgatcccatgcc a" /listShort="yyaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3661457..3661476) /Source="Nicolas_upshift_promotors" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3661463) /Source="Nicolas_upshifts" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3661488..3663557 /gene="yyaL" /locus_tag="BSU_40820" /old_locus_tag="BSU40820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391962.1" /db_xref="EnsemblGenomes-Gn:BSU40820" /db_xref="EnsemblGenomes-Tr:CAB16119" /db_xref="GOA:P37512" /db_xref="InterPro:IPR004879" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR024705" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10040" /db_xref="UniProtKB/Swiss-Prot:P37512" /translation="MPNKSKPNRLINEKSPYLLQHAHNPVDWFPWGEEAFEKAKRENK PVLVSIGYSTCHWCHVMAHESFEDEEIARLLNERFVAIKVDREERPDVDSVYMRICQL MTGQGGWPLNVFITPDQKPFYAGTYFPKTSKFNRPGFVDVLEHLSETFANDREHVEDI AENAAKHLQTKTAAKTGEGLSESAIHRTFQQLASGFDTIYGGFGQAPKFPMPHMLMYL LRYDHNTGQENALYNVTKTLDSMANGGIYDHIGYGFARYSTDDEWLVPHFEKMLYDNA LLLTAYTEAYQVTQNSRYKEICEQIITFIQREMTHEDGSFFSALDADTEGEEGKYYVW SKEEILKTLGDDLGTLYCQVYDITEEGNFEGKNIPNLIHTKREQIKEDAGLTEKELSL KLEDARQQLLKTREERTYPHVDDKVLTSWNALMIAGLAKAAKVYQEPKYLSLAKDAIT FIENKLIIDGRVMVRYRDGEVKNKGFIDDYAFLLWAYLDLYEASFDLSYLQKAKKLTD DMISLFWDEEHGGFYFTGHDAEALIVREKEVYDGAVPSGNSVAAVQLLRLGQVTGDLS LIEKAETMFSVFKPDIEAYPSGHAFFMQSVLRHLMPKKEIVIFGSADDPARKQIIAEL QKAFKPNDSILVAEQPEQCKDIAPFAADYRIIDGKTTVYICENFACQQPTTNIEEAIH TLISSRD*" /label="yyaL CDS" gene 3661488..3663557 /gene="yyaL" /locus_tag="BSU_40820" /old_locus_tag="BSU40820" /label="yyaL gene" promotor_-35 complement(3661490..3661497) /Source="Nicolas_upshift_promotors" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3663521 /Source="Nicolas_upshifts" /id="D2116" /incds=0 /nref=221 /ntot=260 /MaxReadThrough="1.24617" /MaxDrop="5.71843" /score="11.6894527" /energy="-16.6" /TU="NA" /idTUdmin="U3219" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3663554..3664453) /gene="yyaK" /locus_tag="BSU_40830" /old_locus_tag="BSU40830" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11343912, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protease" /protein_id="NP_391963.1" /db_xref="EnsemblGenomes-Gn:BSU40830" /db_xref="EnsemblGenomes-Tr:CAB16120" /db_xref="GOA:P37513" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG10041" /db_xref="UniProtKB/Swiss-Prot:P37513" /translation="MNSFIRPIEGNNTLWRYFFAFLVMVGLYVLGNIAYLFAILFTVI VNPNITFDLDEAVLSDPLVDLYLSHVIYLFAIPGVWLAVRFILKRPFRTVITPNSKMN WRRISFGFIAYFLLMIAVQLIDFVIHPDSYSMQEFNASRFIWLLAAALILVPIQTSAE ELFFRGFLLQAFGRLTKNPLFLTLIVGGLFGVLHFANPEMNNGAVWAGIEYLTFGFVW TYYTIKTGSIEISLGAHAANNMFLCMFITEKNSVYGGIPSLFTVTRGNPMWEAFFTIA VNLVFAGIALWYHKKSKSKQQGS*" /label="yyaK CDS" gene complement(3663554..3664453) /gene="yyaK" /locus_tag="BSU_40830" /old_locus_tag="BSU40830" /label="yyaK gene" downshifts complement(3663597) /Source="Nicolas_upshifts" /id="D2117" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="2.6155" /MaxDrop="3.91098" /score="23.2445146" /energy="-14.7" /TU="NA" /idTUdmin="U3221" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3664482..3664501) /Source="Nicolas_upshift_promotors" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3664498) /Source="Nicolas_upshifts" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3664500..3665731) /Source="Nicolas_S_feature" /locus_tag="new_4194210_4195441_c" /HighExp="S6, S8, S7, S5, B36, BT, S4, B60, S3, Diami" /AntisenseName="yyaJ" /AntisenseCor="-0.24400480530035801" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1573" promotor_-35 complement(3664516..3664523) /Source="Nicolas_upshift_promotors" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3664594..3664601 /Source="Nicolas_upshift_promotors" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3664615..3664634 /Source="Nicolas_upshift_promotors" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3664621 /Source="Nicolas_upshifts" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 3664679..3666034 /gene="yyaJ" /locus_tag="BSU_40840" /old_locus_tag="BSU40840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 9529885, 19087206, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391964.2" /db_xref="EnsemblGenomes-Gn:BSU40840" /db_xref="EnsemblGenomes-Tr:CAB16121" /db_xref="GOA:P37514" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10042" /db_xref="UniProtKB/Swiss-Prot:P37514" /translation="MNTIFKQKNTHPFSNAANRLDRLPISRVHFQVLTALGIVYFFDL ADLFTLSNVAPALIEHWGIPLSTIANVTAASFLGMFLGASLGGRLSDRIGRKKALNLF VFVFSIASLCNAAAWDIPSLMTFRFLTGFGVAAAMVITNSYLAEFFPSSVRGKYISFC AMIGLIGVPITNIVSAFVIPLGSWGWRLVFVWGAVGLIYFFFIHRLEESPRWHENRGE YAKADAILTRIEEQVEKEKGPLPAASQPKVSETVKQNAGYAGLLKGRNLKITIVLSAV WIFETFGFYGFASWVPSLLKSNGVTMENTLWYNVLHSVGAPLGALLGSMISERFQRKW ILAASAFLTAIAGLLYGMTFIPIMIIVFGFIVNITERVFTSNLYAYTSEPYPTEYRSS GSGLAYGLGRFSNIFGSLLVGFIAVQLGYISVFLFIGGCWLACSLLLIFFGPNTNAKQ I*" /label="yyaJ CDS" gene 3664679..3666034 /gene="yyaJ" /locus_tag="BSU_40840" /old_locus_tag="BSU40840" /label="yyaJ gene" promotor_-10 complement(3665717..3665736) /Source="Nicolas_upshift_promotors" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3665741) /Source="Nicolas_upshifts" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3665750..3665759) /Source="Nicolas_upshift_promotors" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3666068..3666622) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /EC_number="2.3.1.79" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12731863, 12793527, 19087206, 22226636, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose O-acetyltransferase" /protein_id="NP_391965.1" /db_xref="EnsemblGenomes-Gn:BSU40850" /db_xref="EnsemblGenomes-Tr:CAB16122" /db_xref="GOA:P37515" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR024688" /db_xref="SubtiList:BG10043" /db_xref="UniProtKB/Swiss-Prot:P37515" /translation="MLRTEKEKMAAGELYNSEDQQLLLERKHARQLIRQYNETPEDDA VRTKLLKELLGSVGDQVTILPTFRCDYGYHIHIGDHTFVNFDCVILDVCEVRIGCHCL IAPGVHIYTAGHPLDPIERKSGKEFGKPVTIGDQVWIGGRAVINPGVTIGDNAVIASG SVVTKDVPANTVVGGNPARILKQL*" /label="maa CDS" gene complement(3666068..3666622) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /label="maa gene" CDS complement(3666640..3667020) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19087206; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_391966.1" /db_xref="EnsemblGenomes-Gn:BSU40860" /db_xref="EnsemblGenomes-Tr:CAB16123" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10044" /db_xref="UniProtKB/Swiss-Prot:P37516" /translation="MQIEHTAVWVNDLERMKSFYESYFNGEANDLYHNEKKDFKSYFI TFDSGARLEIMKKGNVTDPPSQTMTGWAHIAFSVGSREKVDELTDRLKADGFAVVNGP RTTGDGYYESVIEDDEGNLIEITI*" /label="yyaH CDS" gene complement(3666640..3667020) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /label="yyaH gene" CDS complement(3667076..3668011) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9457849, 9642180, 16267306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9457849, 9642180, 16267306; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of carbon supply (LacIfamily)" /protein_id="NP_391967.1" /db_xref="EnsemblGenomes-Gn:BSU40870" /db_xref="EnsemblGenomes-Tr:CAB16124" /db_xref="GOA:P37517" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10045" /db_xref="UniProtKB/Swiss-Prot:P37517" /translation="MANIKEIARLANVSVSTVSRVLNHHPYVSEEKRKLVHQVMKELD YTPNRTAIDLIRGKTHTVGVILPYSDHPCFDKIVNGITKAAFQHEYATTLLPTNYNPD IEIKYLELLRTKKIDGLIITSRANHWDSILAYQEYGPVIACEDTGDIDVPCAFNDRKT AYAESFRYLKSRGHENIAFTCVREADRSPSTADKAAAYKAVCGRLEDRHMLSGCNDMN DGELAAEHFYMSGRVPTAIYANSDEVAAGIHLFAKKNNWDVEIIGEGNTSISRVLGFP SLDLNLEQLGIAAFSLFLQDEPADIKIQHKFKKKA*" /label="ccpB CDS" gene complement(3667076..3668011) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /label="ccpB gene" promotor_-35 3668001..3668010 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3668024..3668043 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3668031 /Source="Nicolas_upshifts" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3668055..3668074) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3668069) /Source="Nicolas_upshifts" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3668070..3668828) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /EC_number="3.1.11.2" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10540738, 16237020, 18203828, 21441501, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10540738, 16237020, 18203828, 21441501, 24244006, 24914186; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="apurinic/apyrimidinic endonuclease" /protein_id="NP_391968.1" /db_xref="EnsemblGenomes-Gn:BSU40880" /db_xref="EnsemblGenomes-Tr:CAB16125" /db_xref="GOA:P37454" /db_xref="InterPro:IPR004808" /db_xref="InterPro:IPR005135" /db_xref="InterPro:IPR020847" /db_xref="InterPro:IPR020848" /db_xref="InterPro:IPR036691" /db_xref="PDB:5CFE" /db_xref="SubtiList:BG10046" /db_xref="UniProtKB/Swiss-Prot:P37454" /translation="MKLISWNVNGLRAVMRKMDFLSYLKEEDADIICLQETKIQDGQV DLQPEDYHVYWNYAVKKGYSGTAVFSKQEPLQVIYGIGVEEHDQEGRVITLEFENVFV MTVYTPNSRRGLERIDYRMQWEEALLSYILELDQKKPVILCGDLNVAHQEIDLKNPKA NRNNAGFSDQEREAFTRFLEAGFVDSFRHVYPDLEGAYSWWSYRAGARDRNIGWRIDY FVVSESLKEQIEDASISADVMGSDHCPVELIINI*" /label="exoA CDS" gene complement(3668070..3668828) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /label="exoA gene" promotor_-35 complement(3668087..3668094) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3668361..3668864 /Source="Nicolas_S_feature" /locus_tag="new_4198071_4198574" /HighExp="C30, S8, S7, S6, BT, S5, M/G, Glucon, C90, T1.0H" /AntisenseName="exoAA" /AntisenseCor="-0.177921457862244" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1574" downshifts 3668823 /Source="Nicolas_upshifts" /id="D2118" /incds=0 /nref=2 /ntot=12 /MaxReadThrough="2.65789" /MaxDrop="4.11352" /score="16.4680636" /energy="-6.8" /TU="NA" /idTUdmin="U3224" /TUdmin=528 /isTUend="FALSE" /label="downshifts" CDS complement(3668893..3669132) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 22720735, 24310371" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 22720735, 24310371; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S18" /protein_id="NP_391969.2" /db_xref="EnsemblGenomes-Gn:BSU40890" /db_xref="EnsemblGenomes-Tr:CAB16126" /db_xref="GOA:P21475" /db_xref="InterPro:IPR001648" /db_xref="InterPro:IPR018275" /db_xref="InterPro:IPR036870" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10047" /db_xref="UniProtKB/Swiss-Prot:P21475" /translation="MAGGRRGGRAKRRKVCYFTSNGITHIDYKDVDLLKKFVSERGKI LPRRVTGTNAKYQRKLTAAIKRARQMALLPYVSGE*" /label="rpsR CDS" gene complement(3668893..3669132) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /label="rpsR gene" downshifts complement(3668899) /Source="Nicolas_upshifts" /id="D2119" /incds=0 /nref=217 /ntot=268 /MaxReadThrough="4.97781" /MaxDrop="7.46952" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227" /idTUdmin="U3229" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3668967) /Source="Nicolas_upshifts" /id="D2120" /incds=1 /nref=13 /ntot=142 /MaxReadThrough="8.89363" /MaxDrop="3.9797" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227,U3229" /idTUdmin="U3229" /TUdmin="-68" /isTUend="FALSE" /label="downshifts" CDS complement(3669176..3669694) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391970.1" /db_xref="EnsemblGenomes-Gn:BSU40900" /db_xref="EnsemblGenomes-Tr:CAB16127" /db_xref="GOA:P37455" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10048" /db_xref="UniProtKB/Swiss-Prot:P37455" /translation="MLNRVVLVGRLTKDPELRYTPNGAAVATFTLAVNRTFTNQSGER EADFINCVTWRRQAENVANFLKKGSLAGVDGRLQTRNYENQQGQRVFVTEVQAESVQF LEPKNGGGSGSGGYNEGNSGGGQYFGGGQNDNPFGGNQNNQRRNQGNSFNDDPFANDG KPIDISDDDLPF*" /label="ssbA CDS" gene complement(3669176..3669694) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /label="ssbA gene" CDS complement(3669735..3670022) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 19653700, 26447183" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 19653700, 26447183; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S6 (BS9)" /protein_id="NP_391971.1" /db_xref="EnsemblGenomes-Gn:BSU40910" /db_xref="EnsemblGenomes-Tr:CAB16128" /db_xref="GOA:P21468" /db_xref="InterPro:IPR000529" /db_xref="InterPro:IPR014717" /db_xref="InterPro:IPR020814" /db_xref="InterPro:IPR020815" /db_xref="InterPro:IPR035980" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10049" /db_xref="UniProtKB/Swiss-Prot:P21468" /translation="MRKYEVMYIIRPNIDEESKKAVIERFNNVLTSNGAEITGTKDWG KRRLAYEINDFRDGFYQIVNVQSDAAAVQEFDRLAKISDDIIRHIVVKEEE*" /label="rpsF CDS" gene complement(3669735..3670022) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /label="rpsF gene" S_feature complement(3670023..3670089) /Source="Nicolas_S_feature" /locus_tag="new_4199733_4199799_c" /HighExp="MG t5, LPhT, GM 90, SMM, T-5.40H, GM-0.2, MG 150, GM 45, Gly, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.993, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1575" promotor_-10 complement(3670088..3670107) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3670089) /Source="Nicolas_upshifts" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3670121..3670126) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3670133..3671233) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12837776, 16014871, 18713637, 21527254, 22995830, 26018081, 26160547, 26912459; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent informational ATPase interacting with 70S ribosome; ROS stress regulator" /protein_id="NP_391972.1" /db_xref="EnsemblGenomes-Gn:BSU40920" /db_xref="EnsemblGenomes-Tr:CAB16129" /db_xref="GOA:P37518" /db_xref="InterPro:IPR004396" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR013029" /db_xref="InterPro:IPR023192" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="SubtiList:BG10050" /db_xref="UniProtKB/Swiss-Prot:P37518" /translation="MALTAGIVGLPNVGKSTLFNAITQAGAESANYPFCTIDPNVGIV EVPDDRLQKLTELVNPKKTVPTAFEFTDIAGIVKGASKGEGLGNKFLSHIRQVDAICH VVRAFSDDNITHVSGKVDPIDDIETINLELILADMETVEKRITRVSKLAKQKDKDAVF EFEILSKLKEAFESEKPARSVEFTEEQQKLVKQLHLLTSKPILYVANVSEDEVADPSG NENVAKIREYAAGENAEVIVVCAKIESEIAELEGEEKQMFLEELGIQESGLDQLIKAS YSLLGLATYFTAGEQEVRAWTFKKGMKAPECAGIIHSDFERGFIRAETVAYEDLLAGG GMAGAKEAGKVRLEGKEYVVQDGDVIHFRFNV*" /label="engD CDS" gene complement(3670133..3671233) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /label="engD gene" promotor_-10 complement(3671281..3671300) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-10" upshifts complement(3671296) /Source="Nicolas_upshifts" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="upshifts" promotor_-35 complement(3671315..3671322) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-35" CDS complement(3671360..3673363) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /EC_number="1.-.-.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17114254, 20817769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (molybdoenzyme)" /protein_id="NP_391973.1" /db_xref="EnsemblGenomes-Gn:BSU40930" /db_xref="EnsemblGenomes-Tr:CAB16130" /db_xref="GOA:P37519" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG10051" /db_xref="UniProtKB/Swiss-Prot:P37519" /translation="MSKVHQSACPLNCWDSCGFLVTVDDGKVTKVDGDPNHPITEGKI CGRGRMLETKTNSPDRLRYPMKKQNGEFVRISWEQALDEIADKLREIKETSETTAVLH SHDYANNGLLKALDQRFFNGYGGVTEIVGSICWGSGIEAQSWDFGRSYGHGPLDIYNS KHVVVWGRNVSRTNMHLYHHLQQVKKKGATITVIDPIFNPTAKLADRYISVKPGMDGW LAAAVLKVLIEMGRTDETFISEHSVGFDDVKELLKTVSLEEFIVKTETSMEELEYLAG LYADGPVSTFMGLGMQRYKNGGGTIRWIDALVAASGNVGIKGGGANFGNVQIGESFAK TKLTLPELKTTSRSFSMMTQAEEVLTAADPAIEMIIVTCGNPLTQVPNTNKVRQAFEK VPMTVAIDSIMTDTAELCDYVLPTATVFEEEDIYYSSMYHHYVQYGKKLVEPQGEAKS DSWIWSELAKRLGFGELFEYSTQEFLEMGLSSLEAEDVTLERLKEKGHLPLPVKQVPW DDYQFLTPSGKFEFTSSLAEQKGFSGSLQLNVPEESVFHNEELAGKYPYTLLSIHPQR SNHSQHVPFIEKLQHVQVDISPDIAAGQDLQDGDEVVIFNDRGSMKGKVKVMKQAHAK TINIDEGMWAAFGGSVNALTNDTNSDNGMGSTLFDCLVGLKKA*" /label="yyaE CDS" gene complement(3671360..3673363) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /label="yyaE gene" CDS complement(3673414..3673620) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21348639, 22333191, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="YP_003097803.1" /db_xref="EnsemblGenomes-Gn:BSU40939" /db_xref="EnsemblGenomes-Tr:CAX52723" /db_xref="InterPro:IPR009296" /db_xref="UniProtKB/Swiss-Prot:C0H3V8" /translation="MADKDFGLNDIVEMKKPHPCGANSWKIIRMGMDIRIKCEGCSHS VMIPRREFERKLKKVLVKHEEPTS*" /label="yyzM CDS" gene complement(3673414..3673620) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /label="yyzM gene" promotor_-10 complement(3673582..3673601) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3673607) /Source="Nicolas_upshifts" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3673616..3673622) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3673646..3673665) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-10" upshifts complement(3673657) /Source="Nicolas_upshifts" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="upshifts" promotor_-35 complement(3673682..3673686) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-35" CDS complement(3673714..3674730) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16847258, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391974.1" /db_xref="EnsemblGenomes-Gn:BSU40940" /db_xref="EnsemblGenomes-Tr:CAB16131" /db_xref="SubtiList:BG10052" /db_xref="UniProtKB/Swiss-Prot:P37520" /translation="MLWRAGMKWMLLILGSLIGAGYASGQEIWQFFGAESGLAIVLFT IMFIFSSYIVMKISFKVQSTHFLPVLEHLMGPWLAKIYDVLIIFYLFSTTMVMIAGGG VTLQMYKLPFWWGITLICIVTVCLFLWDVKGILSINSILIPVLVAGLLYALISFQSTH HHTWTIDLSQQYNWPASITFTSLNILSVVAILSSVGKEMKGLGEAKIASVASGLIFGV ISFVYNETLVELAGSLSQFEIPLFAVLEGAPYFLFLCMTAVLCLAIYTTTVAGLLGLS SRLMAFIHMPRWMIVLILLVLMVPFTSFGFSDLIAFLYPIYGMLNLYLLVCLLLYPIL SKWK*" /label="yyaD CDS" gene complement(3673714..3674730) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /label="yyaD gene" promotor_-10 complement(3674763..3674781) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3674775) /Source="Nicolas_upshifts" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3674797..3674802) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3674906) /Source="Nicolas_upshifts" /id="D2121" /incds=0 /nref=32 /ntot=184 /MaxReadThrough="1.8976" /MaxDrop="3.72136" /score="9.09987016" /energy="-7.4" /TU="NA" /idTUdmin="U3230" /TUdmin="-397" /isTUend="FALSE" /label="downshifts" promotor_-35 3675090..3675095 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3675108..3675189 /Source="Nicolas_S_feature" /locus_tag="new_4204818_4204899" /HighExp="S4, S5, S3, S6, LoTm, S7, T5.0H, BT, M9-stat, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1576" upshifts 3675108 /Source="Nicolas_upshifts" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3675111..3675129 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3675190..3675807 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 26362088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore-specific protease" /protein_id="NP_391975.1" /db_xref="EnsemblGenomes-Gn:BSU40950" /db_xref="EnsemblGenomes-Tr:CAB16132" /db_xref="InterPro:IPR009665" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10053" /db_xref="UniProtKB/Swiss-Prot:P37521" /translation="MNRKGGLFSSQERVKQYVSHTDAAAAKQIQTILSSSLRKAAGKP IVVVCIGTDRSTGDSLGPLVGMKLKQMQLTRFHVYGTLSDPVHAVNMKDKINDIHKLH KNPFVIAVDACLGRVKSVGSFQIGDGPLKPGAGVQKDLPEVGDLHINGIVNVSGFMEY FVLQNTRLNLVMNMANVLAEGLSLTDRTEWRQERLNPLQRLTGRI*" /label="sprC CDS" gene 3675190..3675807 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /label="sprC gene" promotor_-35 3675778..3675786 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3675797 /Source="Nicolas_upshifts" /id="D2122" /incds=0 /nref=11 /ntot=30 /MaxReadThrough="2.64888" /MaxDrop="3.74502" /score="0.352922387" /energy="-6.6" /TU="NA" /idTUdmin="U3231" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 3675800..3675818 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3675819 /Source="Nicolas_upshifts" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3675846..3676694) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103; Product type f: factor" /codon_start=1 /transl_table=11 /product="site-specific DNA-binding protein" /protein_id="NP_391976.1" /db_xref="EnsemblGenomes-Gn:BSU40960" /db_xref="EnsemblGenomes-Tr:CAB16133" /db_xref="GOA:P26497" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10054" /db_xref="UniProtKB/Swiss-Prot:P26497" /translation="MAKGLGKGINALFNQVDLSEETVEEIKIADLRPNPYQPRKHFDD EALAELKESVLQHGILQPLIVRKSLKGYDIVAGERRFRAAKLAGLDTVPAIVRELSEA LMREIALLENLQREDLSPLEEAQAYDSLLKHLDLTQEQLAKRLGKSRPHIANHLRLLT LPENIQQLIAEGTLSMGHGRTLLGLKNKNKLEPLVQKVIAEQLNVRQLEQLIQQLNQN VPRETKKKEPVKDAVLKERESYLQNYFGTTVNIKRQKKKGKIEIEFFSNEDLDRILEL LSERES*" /label="parB CDS" gene complement(3675846..3676694) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /label="parB gene" downshifts complement(3675866) /Source="Nicolas_upshifts" /id="D2123" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="3.01094" /MaxDrop="5.3801" /score="9.82080496" /energy="-7.9" /TU="U3233" /idTUdmin="U3233" /TUdmin="-257" /isTUend="FALSE" /label="downshifts" CDS complement(3676687..3677448) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome partitioning protein; transcriptionalregulator" /protein_id="NP_391977.1" /db_xref="EnsemblGenomes-Gn:BSU40970" /db_xref="EnsemblGenomes-Tr:CAB16134" /db_xref="GOA:P37522" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10055" /db_xref="UniProtKB/Swiss-Prot:P37522" /translation="MGKIIAITNQKGGVGKTTTSVNLGACLAYIGKRVLLVDIDPQGN ATSGLGIEKADVEQCVYDILVDDADVIDIIKATTVENLDVIPATIQLAGAEIELVPTI SREVRLKRALEAVKQNYDYIIIDCPPSLGLLTINALTASDSVVIPVQCEYYALEGLSQ LLNTVRLVQKHLNTDLMIEGVLLTMLDARTNLGIQVIEEVKKYFRDKVYKTVIPRNVR LSEAPSHGKPIILYDPRSRGAEVYLDLAKEVAANG*" /label="parA CDS" gene complement(3676687..3677448) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /label="parA gene" misc_feature complement(3677482..3677501) /Source="Nicolas_upshift_promotors" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3677500) /Source="Nicolas_upshifts" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3677592) /Source="Nicolas_upshifts" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="upshifts" promotor_-10 complement(3677595..3677603) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-10" promotor_-35 complement(3677617..3677625) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-35" promotor_-35 3677629..3677637 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3677645 /Source="Nicolas_upshifts" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3677649..3677667 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3677696..3678136 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25651892; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative antibiotic immunity protein" /protein_id="NP_391978.2" /db_xref="EnsemblGenomes-Gn:BSU40980" /db_xref="EnsemblGenomes-Tr:CAB16135" /db_xref="GOA:P37523" /db_xref="InterPro:IPR009589" /db_xref="SubtiList:BG10056" /db_xref="UniProtKB/Swiss-Prot:P37523" /translation="MVYQTKRDVPVTLMIVFLILLIQADAIVPFVLGNMRVSGWIIFI LLTLLNGLIIWSFIDLKYVLKEHHLIIKAGLIKHQIPYENIDKVVQKKKLWSGFRLIG SRHAITIYYQGGWGHAVISPQKSEEFIHKLKEKNSNIIIFTKSK*" /label="yyaB CDS" gene 3677696..3678136 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /label="yyaB gene" downshifts 3678085 /Source="Nicolas_upshifts" /id="D2124" /incds=0 /nref=3 /ntot=144 /MaxReadThrough="2.25356" /MaxDrop="3.41185" /score="-0.6683508" /energy="-14.5" /TU="NA" /idTUdmin="U3235" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3678187..3679038) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /function="16.13: Shape" /function="16.8: Protect" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11807071, 15210112, 16549676, 25568309, 28500529" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807071, 15210112, 16549676, 25568309, 28500529; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-binding protein Spo0J-like" /protein_id="NP_391979.1" /db_xref="EnsemblGenomes-Gn:BSU40990" /db_xref="EnsemblGenomes-Tr:CAB16136" /db_xref="GOA:P37524" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR023705" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10057" /db_xref="UniProtKB/Swiss-Prot:P37524" /translation="MKHSFSRFFGLGEKEQEPEIAEHDTNKEEILEIPVNAIVPNRFQ PRTIFSDEKIKELAMTIHTHGIIQPIVVRHTEEEGQYELIAGERRWRAVQSLEWEKIP AIIKDFSDTETASVALIENLQREELSSIEEAHAYARLLELHDLTQEALAQRLGKGQST IANKLRLLKLPQPVQEAIMEKKITERHARALIPLKQPELQVTLLTEIIEKSLNVKQTE DRVVKMLEQGQRKPKPRRKAFSRDTRIAMNTIRQSLSMVEDSGVKLNTEEEEFEEYIQ LTIRIPK*" /label="nocA CDS" gene complement(3678187..3679038) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /label="nocA gene" downshifts complement(3678206) /Source="Nicolas_upshifts" /id="D2125" /incds=0 /nref=245 /ntot=265 /MaxReadThrough="2.30868" /MaxDrop="6.68899" /score="29.5496038" /energy="-14.5" /TU="NA" /idTUdmin="U3236" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature complement(3679039..3679159) /Source="Nicolas_S_feature" /locus_tag="new_4208749_4208869_c" /HighExp="LBGstat, G135, G180, H2O2, dia15, G150, Paraq, T0.30H, Oxctl, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1577" CDS complement(3679160..3679879) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /EC_number="2.1.1.170" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12001236, 17238915, 17573471, 19622680, 24509311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12001236, 17238915, 17573471, 19622680, 24509311; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-methylguanosine methyltransferase (16S rRNA, nucleotide G527)" /protein_id="NP_391980.1" /db_xref="EnsemblGenomes-Gn:BSU41000" /db_xref="EnsemblGenomes-Tr:CAB16137" /db_xref="GOA:P25813" /db_xref="InterPro:IPR003682" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XDZ" /db_xref="SubtiList:BG10058" /db_xref="UniProtKB/Swiss-Prot:P25813" /translation="MNIEEFTSGLAEKGISLSPRQLEQFELYYDMLVEWNEKINLTSI TEKKEVYLKHFYDSITAAFYVDFNQVNTICDVGAGAGFPSLPIKICFPHLHVTIVDSL NKRITFLEKLSEALQLENTTFCHDRAETFGQRKDVRESYDIVTARAVARLSVLSELCL PLVKKNGLFVALKAASAEEELNAGKKAITTLGGELENIHSFKLPIEESDRNIMVIRKI KNTPKKYPRKPGTPNKSPIEG*" /label="rsmG CDS" gene complement(3679160..3679879) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /label="rsmG gene" CDS complement(3679893..3681779) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11914360, 14993678, 17062623, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA uridine 5-carboxymethylaminomethyl modification enzyme" /protein_id="NP_391981.1" /db_xref="EnsemblGenomes-Gn:BSU41010" /db_xref="EnsemblGenomes-Tr:CAB16138" /db_xref="GOA:P25812" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004416" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR026904" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10059" /db_xref="UniProtKB/Swiss-Prot:P25812" /translation="MGYEAGQYDVIVIGAGHAGVEAALASARQGAKTLVLTINLDMVA FMPCNPSVGGPAKGIVVREIDALGGEMGRNIDKTHIQMRMLNTGKGPAVRALRAQADK FQYQHEMKNTLEKEPNLTLLQGIVERLIVEDGECRGVITQTGAHYRAKAVVMTTGTYL RGRIILGDLSYSSGPNNQQPSIKLSEHLEELGFDLVRFKTGTPPRVKSDTIDYSKTEI QPGDDVPRAFSYETVEYITDQLPCWLTYTSPETHEIIDSNLHRSPMYSGMIKGTGPRY CPSIEDKVVRFNDKPRHQIFLEPEGRNTQEVYVQGLSTSLPEDVQQRMLATIPGLENV QMMRAGYAIEYDAIVPTQLWPTLETKKITNLYTAGQINGTSGYEEAAGQGIMAGINAG RKALGKEEVILSRSDAYIGVLIDDLVTKGTNEPYRLLTSRAEYRLLLRHDNADLRLTE IGHRIGLISDERYAAFEKKKAAIEAEKKRLHSVIIKPSPENQEYIRSLGGSELKDGVR GTDLMKRPEMNYETVTKLAPPEVPVPQDVAEQVEIQVKYEGYIEKSLQQVEKLKKMEN KKIPDRIDYDAIKGIATEARQKLKNVRPLSVAQASRISGVNPADISILLVYLEQGRIA KIAE*" /label="trmF CDS" gene complement(3679893..3681779) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /label="trmF gene" CDS complement(3681800..3683179) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /EC_number="3.6.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15522079, 15616586, 19052377, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA modification GTPase and tRNA-U34 5-formylation enzyme" /protein_id="NP_391982.1" /db_xref="EnsemblGenomes-Gn:BSU41020" /db_xref="EnsemblGenomes-Tr:CAB16139" /db_xref="GOA:P25811" /db_xref="InterPro:IPR004520" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR018948" /db_xref="InterPro:IPR025867" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031168" /db_xref="SubtiList:BG10060" /db_xref="UniProtKB/Swiss-Prot:P25811" /translation="MDTIAAISTPMGEGAIAIVRLSGPEAIQIADKIYKGPKGKTLSS VESHTIHYGHIVDRPSDRVVEEVMVSVLKAPRTFTREDVIEINCHGGIVTVNQVLQLA LREGARLAEPGEFTKRAFLNGRIDLSQAEAVMDLIRAKTDRAMNVAMNQMEGRLSALV RRLRSEILETLAHVEVNIDYPEYDDVEEMTHQILVEKATAVKKEIETLLRTSEQGKIL REGLSTVIIGRPNVGKSSLLNSLVHEAKAIVTDIPGTTRDVIEEYVNVRGVPLRLVDT AGIRETEDIVERIGVERSRQVLKEADLILLVLNYSEELSEEDVKLFEAVEGMDVIVIL NKTDLEPKIDTERVRELANGRPVVTTSLLKEEGINDLEEAIQSLFYTGAIESGDLTYV SNTRHITILQQAKRAIEDALSGIEQDVPIDMVQIDLTRCWELLGEIIGDSVHESLIDQ LFSQFCLGK*" /label="mnmE CDS" gene complement(3681800..3683179) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /label="mnmE gene" S_feature complement(3683180..3683310) /Source="Nicolas_S_feature" /locus_tag="new_4212890_4213020_c" /HighExp="dia15, Diami, LBGstat, H2O2, Paraq, dia5, G180, T0.30H, LBGexp, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1578" promotor_-10 complement(3683302..3683321) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3683310) /Source="Nicolas_upshifts" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3683337..3683341) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3683365..3683384) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-10" upshifts complement(3683375) /Source="Nicolas_upshifts" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="upshifts" promotor_-35 complement(3683398..3683405) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-35" promotor_-35 3683465..3683471 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3683476..3685761 /Source="Nicolas_S_feature" /locus_tag="new_4213186_4215471" /HighExp="T0.30H, C30, T1.0H, T1.30H, S2, T0.0H, T-1.10H, T-0.40H, T-1.40H, C90" /AntisenseName="oxaAA" /AntisenseCor="-0.20593684080740801" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.685" /TUlongSig="NA" /TUlongPSig="NA" /label="S1579" upshifts 3683476 /Source="Nicolas_upshifts" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3683486..3683505 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3683490..3684116) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1487728, 12813085, 26883633, 27776484; Product type f: factor" /codon_start=1 /transl_table=11 /product="SpoIIIJ-associated RNA/ssDNA-binding protein" /protein_id="NP_391983.1" /db_xref="EnsemblGenomes-Gn:BSU41030" /db_xref="EnsemblGenomes-Tr:CAB16140" /db_xref="GOA:Q01620" /db_xref="InterPro:IPR001374" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR032782" /db_xref="InterPro:IPR034079" /db_xref="InterPro:IPR036867" /db_xref="SubtiList:BG10061" /db_xref="UniProtKB/Swiss-Prot:Q01620" /translation="MRNVTAAGRNVDEAVQSGLQELGLTKDKVEITVIEEGNKGFLGI FGKKPAIVKLVEKIDPIQQAKLYLQTIAEAIAGKSDVTVQESKKTVRYHITGEKAALL IGKRGQTLNALETLTQLALNRYPGQYKNVTVDAENYRLKRKETLSQLAIKLADQVLKT KKSIQLEPMPSSERKIIHDTLSGYANHQIKTYSMGEGENRHLVISHKR*" /label="jag CDS" gene complement(3683490..3684116) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /label="jag gene" downshifts complement(3683507) /Source="Nicolas_upshifts" /id="D2126" /incds=0 /nref=229 /ntot=258 /MaxReadThrough="2.29192" /MaxDrop="6.32351" /score="24.2602773" /energy="-14.1" /TU="NA" /idTUdmin="U3239" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3684113..3684898) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_391984.1" /db_xref="EnsemblGenomes-Gn:BSU41040" /db_xref="EnsemblGenomes-Tr:CAB16141" /db_xref="GOA:Q01625" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG10062" /db_xref="UniProtKB/Swiss-Prot:Q01625" /translation="MLLKRRIGLLLSMVGVFMLLAGCSSVKEPITADSPHFWDKYVVY PLSELITYVAKLTGDNYGLSIILVTILIRLLILPLMIKQLRSSKAMQALQPEMQKLKE KYSSKDQKTQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISEH SFLWFDLGEKDPYYILPIVAGVATFVQQKLMMAGNAQQNPQMAMMLWIMPIMIIVFAI NFPAALSLYWVVGNLFMIAQTFLIKGPDIKKNPEPQKAGGKKK*" /label="oxaAA CDS" gene complement(3684113..3684898) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /label="oxaAA gene" promotor_-10 complement(3684943..3684962) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3684955) /Source="Nicolas_upshifts" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3684957..3685042) /Source="Nicolas_S_feature" /locus_tag="new_4214667_4214752_c" /HighExp="G135, G180, H2O2, Oxctl, Paraq, G150, Cold, LPh, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1580" promotor_-35 complement(3684974..3684980) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3685043..3685393) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /EC_number="3.1.26.5" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16061811, 16163391, 16980484, 17299131, 21347352, 24580115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein component of ribonuclease P (RNase P) (substrate specificity)" /protein_id="NP_391985.1" /db_xref="EnsemblGenomes-Gn:BSU41050" /db_xref="EnsemblGenomes-Tr:CAB16142" /db_xref="GOA:P25814" /db_xref="InterPro:IPR000100" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020539" /db_xref="InterPro:IPR020568" /db_xref="PDB:1A6F" /db_xref="PDB:4JG4" /db_xref="SubtiList:BG10063" /db_xref="UniProtKB/Swiss-Prot:P25814" /translation="MKKRNRLKKNEDFQKVFKHGTSVANRQFVLYTLDQPENDELRVG LSVSKKIGNAVMRNRIKRLIRQAFLEEKERLKEKDYIIIARKPASQLTYEETKKSLQH LFRKSSLYKKSSSK*" /label="rnpA CDS" gene complement(3685043..3685393) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /label="rnpA gene" S_feature complement(3685394..3685544) /Source="Nicolas_S_feature" /locus_tag="new_4215104_4215254_c" /HighExp="G135, G180, Oxctl, H2O2, Paraq, Cold, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1581" CDS complement(3685545..3685679) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7539334, 9371771, 12682299, 23002217, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7539334, 9371771, 12682299, 23002217, 25182490; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L34" /protein_id="NP_391986.1" /db_xref="EnsemblGenomes-Gn:BSU41060" /db_xref="EnsemblGenomes-Tr:CAB16143" /db_xref="GOA:P05647" /db_xref="InterPro:IPR000271" /db_xref="InterPro:IPR020939" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10064" /db_xref="UniProtKB/Swiss-Prot:P05647" /translation="MKRTFQPNNRKRSKVHGFRSRMSSKNGRLVLARRRRKGRKVLSA *" /label="rpmH CDS" gene complement(3685545..3685679) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /label="rpmH gene" promotor_no_box 3685703..3685803 /Source="Nicolas_upshift_promotors" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(3685715..3685734) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3685725) /Source="Nicolas_upshifts" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3685727..3685795) /Source="Nicolas_S_feature" /locus_tag="new_4215437_4215505_c" /HighExp="Oxctl, G180, Paraq, H2O2, LBGstat, GM 120, MG-0.2, HPh, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1582" promotor_-35 complement(3685750..3685757) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3685763..>3685896 /Source="Nicolas_S_feature" /locus_tag="new_4215473_4215670" /HighExp="T0.30H, C30, T1.0H, T1.30H, T0.0H, T-0.40H, S2, T-1.10H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.048" /TUlongSig="NA" /TUlongPSig="NA" /label="S1583" upshifts 3685763 /Source="Nicolas_upshifts" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3685781..3685800) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3685795) /Source="Nicolas_upshifts" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3685816..3685820) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3685897..3686044 /locus_tag="new_1_148" /created_by="stephanmichalik" /label="S1" S_feature complement(3685920..3686193) /locus_tag="new_24_297_c" /created_by="stephanmichalik" /label="S2" S_feature 3686046..3686305 /locus_tag="new_150_409" /created_by="stephanmichalik" /label="S3" ORIGIN 1 atggaaaata tattagacct gtggaaccaa gcccttgctc aaatcgaaaa aaagttgagc 61 aaaccgagtt ttgagacttg gatgaagtca accaaagccc actcactgca aggcgataca 121 ttaacaatca cggctcccaa tgaatttgcc agagactggc tggagtccag atacttgcat 181 ctgattgcag atactatata tgaattaacc ggggaagaat tgagcattaa gtttgtcatt 241 cctcaaaatc aagatgttga ggactttatg ccgaaaccgc aagtcaaaaa agcggtcaaa 301 gaagatacat ctgattttcc tcaaaatatg ctcaatccaa aatatacttt tgatactttt 361 gtcatcggat ctggaaaccg atttgcacat gctgcttccc tcgcagtagc ggaagcgccc 421 gcgaaagctt acaacccttt atttatctat gggggcgtcg gcttagggaa aacacactta 481 atgcatgcga tcggccatta tgtaatagat cataatcctt ctgccaaagt ggtttatctg 541 tcttctgaga aatttacaaa cgaattcatc aactctatcc gagataataa agccgtcgac 601 ttccgcaatc gctatcgaaa tgttgatgtg cttttgatag atgatattca atttttagcg 661 gggaaagaac aaacccagga agaatttttc catacattta acacattaca cgaagaaagc 721 aaacaaatcg tcatttcaag tgaccggccg ccaaaggaaa ttccgacact tgaagacaga 781 ttgcgctcac gttttgaatg gggacttatt acagatatca caccgcctga tctagaaacg 841 agaattgcaa ttttaagaaa aaaggccaaa gcagagggcc tcgatattcc gaacgaggtt 901 atgctttaca tcgcgaatca aatcgacagc aatattcggg aactcgaagg agcattaatc 961 agagttgtcg cttattcatc tttaattaat aaagatatta atgctgatct ggccgctgag 1021 gcgttgaaag atattattcc ttcctcaaaa ccgaaagtca ttacgataaa agaaattcag 1081 agggtagtag gccagcaatt taatattaaa ctcgaggatt tcaaagcaaa aaaacggaca 1141 aagtcagtag cttttccgcg tcaaatcgcc atgtacttat caagggaaat gactgattcc 1201 tctcttccta aaatcggtga agagtttgga ggacgtgatc atacgaccgt tattcatgcg 1261 catgaaaaaa tttcaaaact gctggcagat gatgaacagc ttcagcagca tgtaaaagaa 1321 attaaagaac agcttaaata gcaggaccgg ggatcaatcg gggaaagtgt gaataacttt 1381 tcggaagtca tacacagtct gtccacatgt ggataggctg tgtttcctgt ctttttcaca 1441 acttatccac aaatccacag gccctactat tacttctact attttttata aatatatata 1501 ttaatacatt atccgttagg aggataaaaa tgaaattcac gattcaaaaa gatcgtcttg 1561 ttgaaagtgt ccaagatgta ttaaaagcag tttcatccag aaccacgatt cccattctga 1621 ctggtattaa aattgttgca tcagatgatg gagtatcctt tacagggagt gactcagata 1681 tttctattga atccttcatt ccaaaagaag aaggagataa agaaatcgtc actattgaac 1741 agcccggaag catcgtttta caggctcgct tttttagtga aattgtaaaa aaattgccga 1801 tggcaactgt agaaattgaa gtccaaaatc agtatttgac gattatccgt tctggtaaag 1861 ctgaatttaa tctaaacgga ctggatgctg atgaatatcc gcacttgccg cagattgaag 1921 agcatcatgc gattcagatc ccaactgatt tgttaaaaaa tctaatcaga caaacagtat 1981 ttgcagtgtc cacctcagaa acacgcccta tcttgacagg tgtaaactgg aaagtggagc 2041 aaagtgaatt attatgcact gcaacggata gccaccgtct tgcattaaga aaggcgaaac 2101 ttgatattcc agaagacaga tcttataacg tcgtgattcc gggaaaaagt ttaactgaac 2161 tcagcaagat tttagatgac aaccaggaac ttgtagatat cgtcatcaca gaaacccaag 2221 ttctgtttaa agcgaaaaac gtcttgttct tctcacggct tctggacggg aattatccag 2281 acacaaccag cctgattccg caagacagca aaacagaaat cattgtgaac acaaaagaat 2341 tccttcaggc cattgatcgt gcatctcttt tagctagaga gggacgcaac aacgttgtaa 2401 aactgtccgc aaaaccggct gaatccattg aaatttcttc caattcgcca gaaatcggta 2461 aagttgtgga agcaattgtt gcggatcaaa ttgaaggtga ggaattaaat atctctttta 2521 gtccaaaata tatgctggat gcactaaagg tgcttgaagg agcagaaata cgcgtaagct 2581 ttacaggcgc aatgagacct ttcttaattc gcacgccgaa tgatgaaacg attgtacagc 2641 ttatccttcc tgtcagaacc tattaatccg atacactgct gccgacccgt cggcagcttt 2701 tctattcggt atctgctccg acaagttttc cctttcccta attcgttttt ttttagtaca 2761 attagatatt agtgatattt gaaagaggtc gatataatgg caaatccgat ttcaattgat 2821 acagagatga ttacactcgg acaattctta aaattagccg atgtgattca gtctggcggt 2881 atggcgaagt ggtttttaag cgagcatgaa gtgcttgtga acgatgagcc ggacaaccgc 2941 cggggcagaa agctgtatgt tggagatgtg gtagagattg aaggatttgg ttcatttcaa 3001 gtcgtcaatt aaagcgggtg acactgattg tatatccaga acttagaact gacatcttac 3061 cgcaactacg accatgctga acttcaattt gaaaataaag taaatgtgat catcggagaa 3121 aacgcccagg ggaagacaaa cctcatggag gcgatctatg tcttgtccat ggcgaaatcg 3181 caccggacat caaatgacaa agaacttata cggtgggaca aagactatgc taaaatagag 3241 ggaagagtga tgaagcaaaa cggggcgatc ccgatgcagc tcgtcatctc caaaaagggt 3301 aaaaagggca aggtcaatca tattgaacag caaaagctca gccagtatgt cggggccctc 3361 aacaccatta tgttcgcgcc ggaagattta aatcttgtaa agggaagccc tcaagtgaga 3421 aggcggtttc ttgacatgga aatcggacag gtttctcccg tctaccttca tgatctttct 3481 ctttaccaga aaatcctttc ccagcggaat cattttttga aacagctgca aacaagaaaa 3541 caaactgacc ggacgatgct cgatgttctg accgatcagc ttgtagaagt tgcagcaaaa 3601 gtcgtcgtaa aacgcctgca gtttacagca cagctcgaga aatgggcgca gcccatccat 3661 gcaggcatct caagagggct tgaagaactg accctgaaat accatacagc tcttgatgta 3721 tcagatcccc tagatttgtc gaaaatagga gatagctatc aagaagcgtt ttctaaatta 3781 agagaaaaag aaattgagcg tggtgtgacg ctgtcagggc ctcatcgcga tgatgttctt 3841 ttctatgtga acggacgcga tgtgcagacg tatggttctc aaggacagca gcgaacgacg 3901 gcgttgtccc ttaagctggc ggagattgac ctgatccatg aagaaatcgg agaatatccc 3961 attttactat tggatgatgt actgagtgaa ctggatgatt atcgccagtc acacttgctt 4021 catacgatcc aaggccgtgt acaaacgttt gtcacaacga caagcgttga tggcattgat 4081 cacgaaacct tacgtcaagc aggaatgttc cgtgtgcaaa atggtgcgtt agtgaagtga 4141 agaaatgagg tgagcaattg tatattcatt taggtgatga ctttgtggtt tcaacacgag 4201 atattgtcgg catttttgac tttaaagcca acatgtcgcc tattgttgaa gaatttctga 4261 aaaaacagaa acacaaggtg gtgccttccg taaacggcac gcccaaatct atcgtagtca 4321 cggttcagaa tatatattac tctcccttat cttccagcac attaaaaaaa cgtgcgcaat 4381 ttatgtttga aatagattct tagaaatttt ttatcacgaa tatatcgttt agaaaagtgt 4441 aggtgaatga cgtggctatg gaacagcagc aaaacagtta tgatgaaaat cagatacagg 4501 tactagaagg attggaagct gttcgtaaaa gaccggggat gtatatcggt tcgacaaaca 4561 gcaaaggcct tcaccacttg gtatgggaaa ttgtcgacaa tagtattgac gaagccctcg 4621 ccggttattg tacggatatc aatatccaaa tcgaaaaaga caacagtatc acggttgtag 4681 ataatggccg cggtattcca gtcggtattc atgaaaaaat gggccgtcct gcggtagaag 4741 tcattatgac ggtgcttcat gccggaggaa aatttgacgg aagcggctat aaagtatccg 4801 gaggattaca cggtgtaggt gcgtcggtcg taaacgcact atcaacagag cttgatgtga 4861 cggttcaccg tgacggtaaa attcaccgcc aaacctataa acgcggagtt ccggttacag 4921 accttgaaat cattggcgaa acggatcata caggaacgac gacacatttt gtcccggacc 4981 ctgaaatttt ctcagaaaca accgagtatg attacgatct gcttgccaac cgcgtgcgtg 5041 aattagcctt tttaacaaag ggcgtaaaca tcacgattga agataaacgt gaaggacaag 5101 agcgcaaaaa tgaataccat tacgaaggcg gaattaaaag ttatgtagag tatttaaacc 5161 gctctaaaga ggttgtccat gaagagccga tttacattga aggcgaaaag gacggcatta 5221 cggttgaagt ggctttgcaa tacaatgaca gctacacaag caacatttac tcgtttacaa 5281 acaacattaa cacgtacgaa ggcggtaccc atgaagctgg cttcaaaacg ggcctgactc 5341 gtgttatcaa cgattacgcc agaaaaaaag ggcttattaa agaaaatgat ccaaacctaa 5401 gcggagatga cgtaagggaa gggctgacag cgattatttc aatcaaacac cctgatccgc 5461 agtttgaggg ccaaacaaaa acaaagctgg gcaactcaga agcacggacg atcaccgata 5521 cgttattttc tacggcgatg gaaacattta tgctggaaaa tccagatgca gccaaaaaaa 5581 ttgtcgataa aggtttaatg gcggcaagag caagaatggc tgcgaaaaaa gcgcgtgaac 5641 taacacgccg taagagtgct ttggaaattt caaacctgcc cggtaagtta gcggactgct 5701 cttcaaaaga tccgagcatc tccgagttat atatcgtaga gggtgactct gccggaggat 5761 ctgctaaaca aggacgcgac agacatttcc aagccatttt gccgcttaga ggtaaaatcc 5821 taaacgttga aaaggccaga ctggataaaa tcctttctaa caacgaagtt cgctctatga 5881 tcacagcgct cggcacaggt atcggagaag acttcaacct tgagaaagcc cgttaccaca 5941 aagttgtcat tatgacagat gccgatgttg acggcgcgca catcagaaca ctgctgttaa 6001 cgttctttta cagatatatg cgccaaatta tcgaaaatgg ctacgtgtac attgcgcagc 6061 cgccgctcta caaggttcaa caggggaaac gcgttgaata tgcatacaat gacaaggagc 6121 ttgaagagct gttaaaaact cttcctcaaa cgcctaagcc tggactgcag cgttacaaag 6181 gtcttggtga aatgaatgcc acccagctat gggagacaac catggatcct agctccagaa 6241 cacttcttca ggtaactctt gaagatgcaa tggatgcgga tgagactttt gaaatgctta 6301 tgggcgacaa ggtagaaccg cgccgaaact tcatagaagc gaatgcgaga tacgttaaaa 6361 atcttgacat ctaatcataa aaagccttat ttccaataag aaataaggct tttttctgaa 6421 caagatcaga tgcagcgatg cctgcaatac ctatatattc tagcaattta atgtgtataa 6481 tcataagttt attgatataa tggagaatag tgaaatcgta ttgaaggtca taatggacaa 6541 tctactccca catatttcat gtgatacttc agggaggttt tttaatgagt gaacaaaaca 6601 caccacaagt tcgtgaaata aatatcagtc aggaaatgcg tacgtccttc ttggattatg 6661 caatgagcgt tatcgtgtcc cgtgctcttc cggatgttcg tgacggttta aaaccggttc 6721 atagacggat tttgtatgca atgaatgatt taggcatgac aagtgacaag ccttataaaa 6781 aatccgcgcg tatcgttgga gaagttatcg ggaaatacca cccgcacggt gattcagcgg 6841 tatatgaatc catggtcaga atggctcagg atttcaacta ccgttatatg ctcgttgacg 6901 gtcacggaaa cttcggttct gttgacggag actcagcggc ggccatgcgt tatacagaag 6961 cacgaatgtc taaaatctca atggagattc ttcgcgacat cacaaaagac acaatcgatt 7021 accaggataa ctatgacggg tcagaaagag aacctgtcgt tatgccttca aggttcccga 7081 atctgctcgt gaacggtgct gccggcattg cggtaggtat ggcaacaaac attcctccgc 7141 accagctggg agaaatcatt gacggtgtac ttgctgttag tgagaatccg gacattacaa 7201 ttccagagct tatggaagtc attccagggc ctgatttccc gaccgcgggt caaatcttgg 7261 gacgcagcgg tatccggaaa gcatacgaat caggccgagg ctctatcacg atccgggcaa 7321 aagctgagat cgaacaaaca tcttcgggta aagaaagaat tatcgttaca gagttacctt 7381 accaagtaaa taaggcgaaa ttaattgaga aaattgctga tctcgtaagg gacaaaaaga 7441 tagagggtat cacagatctg cgtgatgagt cagatcgtac aggtatgaga attgtcattg 7501 aaatcagacg cgatgccaat gcgaatgtta tcttaaacaa tctgtacaaa caaactgctc 7561 tacaaacatc ttttggcatc aacctgcttg cgcttgttga tggccagccg aaagttttaa 7621 ctcttaagca atgcctggag cattaccttg accatcaaaa agttgtcatt agacgccgta 7681 ctgcttatga attgcgtaaa gcagaagcga gagctcatat cttggaagga ttgagagttg 7741 cactggatca tctcgatgca gttatctccc ttatccgtaa ttctcaaacg gctgaaattg 7801 cgagaacagg tttaattgaa caattctcac tgacagagaa gcaagcacaa gcgatccttg 7861 acatgaggct ccagcgttta acgggactgg aacgtgaaaa gatcgaagaa gaataccagt 7921 ctcttgttaa attaattgca gagctaaaag acatcttggc aaatgaatat aaagtgcttg 7981 agatcattcg tgaagaactc acggaaatca aagagcgttt taacgatgaa agacgtactg 8041 agatcgtcac ttctggactg gagacaattg aagatgaaga tctcatcgag agagaaaata 8101 tcgtagttac tctgacgcac aacggatacg tcaaacgtct tcctgcatca acttaccgca 8161 gtcaaaaacg gggcggaaaa ggtgtacaag gtatgggaac aaacgaagat gatttcgttg 8221 aacatttgat ctctacgtca actcatgaca cgattctctt cttctcgaac aaggggaaag 8281 tgtatcgtgc aaaagggtat gaaatccctg aatacggcag aacggcaaaa ggaatcccga 8341 ttattaacct gctggaggta gaaaagggtg agtggatcaa cgcgattatt ccagtcacgg 8401 aattcaatgc ggagctttac ctcttcttca ctacaaagca tggggtttca aaacgaacat 8461 cgctatctca attcgctaat atccgcaaca atggtctaat tgctctgagt cttcgtgaag 8521 atgatgaact gatgggtgta cgtctgactg acggcacaaa acaaatcatc attggaacga 8581 aaaacggttt actgattcgt ttccctgaaa cagatgtccg agagatggga agaactgcgg 8641 cgggcgtaaa aggcatcacc ctgacggatg acgacgttgt tgtcggcatg gagattttag 8701 aggaagaatc acacgtcctt atcgtaactg aaaaagggta cggaaaacga actcctgctg 8761 aagagtacag aacccaaagc cggggcggaa aaggactcaa aacagcgaaa atcaccgaga 8821 acaacggcca actagtagca gtgaaagcta ctaaaggtga agaggatcta atgattatta 8881 cagctagcgg cgtactcatc agaatggaca tcaatgatat ctccatcacc ggacgtgtca 8941 ctcaaggtgt gcgtctcatc agaatggcag aagaagagca tgttgctaca gtagctttag 9001 ttgagaaaaa cgaagaagat gagaatgaag aagaacaaga agaagtgtga aaaaaagcgc 9061 agctgaaata gctgcgcttt tttgtgtcat aaccctttac agtcataaaa attatggtat 9121 aatcatttct gttgtctttt taaagacaca agcatgacca ttatgactag taaaaacttt 9181 ttcaaaaaag tattgaccta gttaactaaa aatgttacta ttaagtagtc gctttgagag 9241 aagcacacaa agttctttga aaactaaaca agacaaaacg tacctgttaa ttcattttta 9301 taaatcgcac agcgatgtgc gtagtcagtc aaactagggc ctgcacgacg caggtcacac 9361 aggtgtcgcc gcaggatgcg gtgaacttaa cctgtgatcc atttatcgga gagtttgatc 9421 ctggctcagg acgaacgctg gcggcgtgcc taatacatgc aagtcgagcg gacagatggg 9481 agcttgctcc ctgatgttag cggcggacgg gtgagtaaca cgtgggtaac ctgcctgtaa 9541 gactgggata actccgggaa accggggcta ataccggatg gttgtttgaa ccgcatggtt 9601 caaacataaa aggtggcttc ggctaccact tacagatgga cccgcggcgc attagctagt 9661 tggtgaggta acggctcacc aaggcgacga tgcgtagccg acctgagagg gtgatcggcc 9721 acactgggac tgagacacgg cccagactcc tacgggaggc agcagtaggg aatcttccgc 9781 aatggacgaa agtctgacgg agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa 9841 gctctgttgt tagggaagaa caagtgccgt tcgaataggg cggtaccttg acggtaccta 9901 accagaaagc cacggctaac tacgtgccag cagccgcggt aatacgtagg tggcaagcgt 9961 tgtccggaat tattgggcgt aaagggctcg caggcggttt cttaagtctg atgtgaaagc 10021 ccccggctca accggggagg gtcattggaa actggggaac ttgagtgcag aagaggagag 10081 tggaattcca cgtgtagcgg tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg 10141 cgactctctg gtctgtaact gacgctgagg agcgaaagcg tggggagcga acaggattag 10201 ataccctggt agtccacgcc gtaaacgatg agtgctaagt gttagggggt ttccgcccct 10261 tagtgctgca gctaacgcat taagcactcc gcctggggag tacggtcgca agactgaaac 10321 tcaaaggaat tgacgggggc ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac 10381 gcgaagaacc ttaccaggtc ttgacatcct ctgacaatcc tagagatagg acgtcccctt 10441 cgggggcaga gtgacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt 10501 taagtcccgc aacgagcgca acccttgatc ttagttgcca gcattcagtt gggcactcta 10561 aggtgactgc cggtgacaaa ccggaggaag gtggggatga cgtcaaatca tcatgcccct 10621 tatgacctgg gctacacacg tgctacaatg gacagaacaa agggcagcga aaccgcgagg 10681 ttaagccaat cccacaaatc tgttctcagt tcggatcgca gtctgcaact cgactgcgtg 10741 aagctggaat cgctagtaat cgcggatcag catgccgcgg tgaatacgtt cccgggcctt 10801 gtacacaccg cccgtcacac cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt 10861 ttaggagcca gccgccgaag gtgggacaga tgattggggt gaagtcgtaa caaggtagcc 10921 gtatcggaag gtgcggctgg atcacctcct ttctaaggat attttacgga atataagacc 10981 ttgggtctta taaacagaac gttccctgtc ttgtttagtt ttgaaggaac tttgttcctt 11041 gaataagtta agatgggcct gtagctcagc tggttagagc gcacgcctga taagcgtgag 11101 gtcggtggtt cgagtccact caggcccacc atcttatata acggggcctt agctcagctg 11161 ggagagcgcc tgctttgcac gcaggaggtc agcggttcga tcccgctagg ctccaccaac 11221 gtgttctttg aaaactagat aacagtagac atcacattca attagtaaca caagatatca 11281 catagtgatt ctttttaacg gttaagttag aaagggcgca cggtggatgc cttggcacta 11341 ggagccgatg aaggacggga cgaacaccga tatgcttcgg ggagctgtaa gcaagctttg 11401 atccggagat ttccgaatgg ggaaacccac cactcgtaat ggagtggtat ccatatctga 11461 attcatagga tatgagaagg cagacccggg gaactgaaac atctaagtac ccggaggaag 11521 agaaagcaaa tgcgattccc tgagtagcgg cgagcgaaac gggatcagcc caaaccaaga 11581 ggcttgcctc ttggggttgt aggacactct gtacggagtt acaaaggaac gaggtagatg 11641 aagaggtctg gaaaggcccg ccataggagg taacagccct gtagtcaaaa cttcgttctc 11701 tcctgagtgg atcctgagta cggcggaaca cgtgaaattc cgtcggaatc cgggaggacc 11761 atctcccaag gctaaatact ccctagtgac cgatagtgaa ccagtaccgt gagggaaagg 11821 tgaaaagcac cccggaaggg gagtgaaaga gatcctgaaa ccgtgtgcct acaagtagtc 11881 agagcccgtt aacgggtgat ggcgtgcctt ttgtagaatg aaccggcgag ttacgatctc 11941 gtgcaaggtt aagcagaaga tgcggagccg cagcgaaagc gagtctgaat agggcgcatg 12001 agtacgtggt cgtagacccg aaaccaggtg atctacccat gtccagggtg aagttcaggt 12061 aacactgaat ggaggcccga acccacgcac gttgaaaagt gcggggatga ggtgtgggta 12121 ggggtgaaat gccaatcgaa cctggagata gctggttctc tccgaaatag ctttagggct 12181 agcctcaagg taagagtctt ggaggtagag cactgattgg actaggggcc cctaccgggt 12241 taccgaattc agtcaaactc cgaatgccaa tgacttatcc ttgggagtca gactgcgagt 12301 gataagatcc gtagtcgaaa gggaaacagc ccagaccgcc agctaaggtc ccaaagtata 12361 cgttaagtgg aaaaggatgt ggagttgctt agacaaccag gatgttggct tagaagcagc 12421 caccatttaa agagtgcgta atagctcact ggtcgagtga ctctgcgccg aaaatgtacc 12481 ggggctaaac gtatcaccga agctgcggac tgttcttcga acagtggtag gagagcgttc 12541 taagggctgt gaagccagac cggaaggact ggtggagcgc ttagaagtga gaatgccggt 12601 atgagtagcg aaagaggggt gagaatcccc tccaccgaat gcctaaggtt tcctgaggaa 12661 ggctcgtccg ctcagggtta gtcgggacct aagccgaggc cgaaaggcgt aggcgatgga 12721 caacaggttg atattcctgt accacctcct caccatttga gcaatggggg gacgcaggag 12781 gatagggtaa gcgcggtatt ggatatccgc gtccaagcag ttaggctggg aaataggcaa 12841 atccgtttcc cataaggctg agctgtgatg gcgagcgaaa tatagtagcg aagttcctga 12901 ttccacactg ccaagaaaag cctctagcga ggtgagaggt gcccgtaccg caaaccgaca 12961 caggtaggcg aggagagaat cctaaggtga tcgagagaac tctcgttaag gaactcggca 13021 aaatgacccc gtaacttcgg gagaaggggt gctctgttag ggtgcaagcc cgagagagcc 13081 gcagtgaata ggcccaggcg actgtttagc aaaaacacag gtctctgcga agccgtaagg 13141 cgaagtatag gggctgacgc ctgcccggtg ctggaaggtt aagaggagcg cttagcgtaa 13201 gcgaaggtgc gaattgaagc cccagtaaac ggcggccgta actataacgg tcctaaggta 13261 gcgaaattcc ttgtcgggta agttccgacc cgcacgaaag gcgcaacgat ctgggcactg 13321 tctcaacgag agactcggtg aaattatagt acctgtgaag atgcaggtta cccgcgacag 13381 gacggaaaga ccccgtggag ctttactgca gcctgatatt gaatgttggt acagcttgta 13441 caggataggt aggagccttg gaaaccggag cgccagcttc ggtggaggca tcggtgggat 13501 actaccctgg ctgtattgac cttctaaccc gccgccctta tcgggcgggg agacagtgtc 13561 aggtgggcag tttgactggg gcggtcgcct cctaaaaggt aacggaggcg cccaaaggtt 13621 ccctcagaat ggttggaaat cattcgcaga gtgtaaaggc acaagggagc ttgactgcga 13681 gacctacaag tcgagcaggg acgaaagtcg ggcttagtga tccggtggtt ccgcatggaa 13741 gggccatcgc tcaacggata aaagctaccc cggggataac aggcttatct cccccaagag 13801 tccacatcga cggggaggtt tggcacctcg atgtcggctc atcgcatcct ggggctgtag 13861 tcggtcccaa gggttgggct gttcgcccat taaagcggta cgcgagctgg gttcagaacg 13921 tcgtgagaca gttcggtccc tatccgtcgc gggcgcagga aatttgagag gagctgtcct 13981 tagtacgaga ggaccgggat ggacgcaccg ctggtgtacc agttgttctg ccaagggcat 14041 cgctgggtag ctatgtgcgg acgggataag tgctgaaagc atctaagcat gaagcccccc 14101 tcaagatgag atttcccatt ccgcaaggaa gtaagatccc tgaaagatga tcaggttgat 14161 aggtctgagg tggaagtgtg gcgacacatg gagctgacag atactaatcg atcgaggact 14221 taaccatatt tttgaatgat gtcacacctg ttatctagtt ttgagagaac actctcaatt 14281 tgtttggtgg cgatagcgaa gaggtcacac ccgttcccat accgaacacg gaagttaagc 14341 tcttcagcgc cgatggtagt cgggggtttc cccctgtgag agtaggacgc cgccaagcaa 14401 gcttaaaccc agctcaatga gctgggtttt ttgtttgtta aaaatgaaga agaaactgtg 14461 aagcgtattt agggaatttc ttttctgata ctaataaaaa ctgctgaatt aacacgtagt 14521 catcacttat atgctgtgtt aataactcat accaccattc tgtttcatac cttgcaatca 14581 tcccaacgtt gtacaaaatc aaataatgaa ttgtcatttc gggaagcctc agaaattgct 14641 ccctttgaga agggatataa tattggttct tttccatgtc aaacaataag ctggtcgatg 14701 tccatggctc cttgtcttgt ggtgaaattt cgaacagcag cccgtgttca tttttttttg 14761 taaaagacca ttgataatga tgggacatgt attcagcaaa ccttgaatca gacattttgt 14821 aattgattac tacttcctcc ggtacaaaaa tttcgttctt atccttctca acttttgtca 14881 taaatcgttc tttctgctga aagtagaaaa tatcgctaag ttctggaatg gccattaata 14941 attttttcat ggtataccgt tcatctacta tatccgattg tccgaataaa tgtttcataa 15001 aatgtacgca taggccattc cgttgtattt tcacttcatc gtcgctaaaa caataatttt 15061 gtttctttcg ttttcttgtt gttacgccat gtgccagtac tgatgtatgg cttggataat 15121 gaggatcacg tgtaattaag catgctttga taagctgtgc cattccataa aataaaagaa 15181 tcggtttgat ttctaaggga gaatatgcgg cttgtttata aaacgattcg gcatgcttta 15241 agaaataaat aaaccgttca ctgtttttaa aagagttttt tttcgcatcg ttaataccgt 15301 ttaagatata aaccttttct agaaatttct gggttgattc aacggagtaa aatagcgcta 15361 agtctttcca ctcatgatat gtcatgtata tttcttaatc ctttccgtta tctaaatatt 15421 tcaactcttt cccgcttcct tgacatgctc ttggctagtt gataatctac atataatatt 15481 ttgccgaaaa gagggggatt tactaatgtg ggaaagtaaa ttttcaaaag aaggcttaac 15541 gttcgacgat gtgctgcttg taccagcaaa gtctgaggta cttccgcgtg atgtggattt 15601 atctgtagaa cttacaaaaa cgttaaagct aaatattcct gtcatcagcg caggtatgga 15661 cactgtaaca gaatcagcaa tggcaattgc aatggcaaga cagggcggct tgggcatcat 15721 tcacaaaaat atgtccattg aacagcaggc tgaacaagtt gataaagtaa agcgttctga 15781 gcgcggcgtt atcacaaatc ccttcttttt aactcctgat caccaagtat ttgatgcgga 15841 gcatttgatg gggaaataca gaatttccgg tgttccgatt gtaaataacg aagaagacca 15901 gaagcttgtt ggaattatta caaaccgtga ccttcgtttt atttctgact actcaatgaa 15961 aatcagcgac gtcatgacga aagaagagct agttactgca tctgtaggaa ctactctgga 16021 tgaagctgaa aagattttgc agaaacataa aattgaaaag cttcctctcg tagatgacca 16081 gaataaatta aaaggtctta tcacaattaa agacattgaa aaagtcattg agttcccgaa 16141 ctcatctaaa gacattcacg gccgcctgat cgttggcgcg gcagttggtg taactggcga 16201 tacaatgact cgcgtcaaaa agcttgttga agccaatgtt gatgtgattg ttatcgatac 16261 agctcacgga cactctcaag gcgttttaaa cacagtcaca aaaatccgtg aaacgtatcc 16321 cgaattaaac attattgctg gaaacgtggc aacagctgaa gcgacaagag cgcttatcga 16381 agctggagca gacgttgtca aagttggaat agggcctggt tcaatttgta ctacacgtgt 16441 tgtagccggc gtgggtgttc cgcaaattac agcaatttat gattgtgcga ctgaagcaag 16501 aaaacacggc aaaacaatca tcgccgacgg tgggattaaa ttctctggcg atatcactaa 16561 agcattggca gccggcggac atgctgttat gctcggaagc ttgcttgcag gcacatcaga 16621 aagccctggt gaaactgaaa tctaccaagg cagaagattt aaggtatacc gcggcatggg 16681 atcagttgct gcaatggaaa aaggaagtaa agaccgttac ttccaagaag aaaacaaaaa 16741 atttgttcct gaaggaattg aaggacgcac accttacaaa gggccagttg aagaaaccgt 16801 ttatcagcta gtcggaggcc ttcgttctgg tatggggtat tgcgggtcca aagatctgcg 16861 tgcgctaaga gaagaagctc agttcattcg catgactggc gcaggacttc gcgaaagcca 16921 tccgcatgac gtacagatta caaaagaatc acctaactat acaatttcat aataaattgt 16981 tacaaattaa aaacatttga cagggtctct gactctgtct atttttttta tactgattat 17041 gataaaattt atactgttgt gcattgaaaa tgtccttaac ggcttaatta tagatgaaga 17101 aaatgaaata cggaggtcgt acgattgaac atcaagaaat gtaaacagct actgatgtca 17161 ttggttgtgt taactctagc tgtcacgtgt ctggctccaa tgtcaaaagc gaaagcagcc 17221 agcgatccaa ttgatatcaa tgcatctgct gctattatga tcgaagcttc ttcaggtaaa 17281 attctttaca gtaaaaatgc agataagaga ctgccaattg cgagtatgac aaaaatgatg 17341 acagagtatc tgttattgga agcaattgat caaggtaaag tgaaatggga ccaaacctat 17401 acgcctgatg actatgtgta tgaaatttcc caagataaca gcttatcaaa cgttcctctt 17461 cggaaagacg ggaaatacac agtaaaagaa ttatatcaag ctacagcaat ttattctgca 17521 aatgctgctg ctattgcgat tgcagaaatc gttgccggtt ctgaaactaa gtttgttgaa 17581 aaaatgaatg caaaagcaaa agaactaggc ttaacagatt acaaatttgt taacgcaaca 17641 ggtcttgaaa acaaagatct tcacgggcat cagcctgagg ggacaagcgt aaatgaagaa 17701 agtgaagttt ctgcaaagga tatggcggtt cttgcggatc acttgattac tgactaccct 17761 gagatactgg agacttccag tatcgccaaa acgaaattca gagaaggcac cgatgatgaa 17821 atggacatgc cgaactggaa ttttatgctg aaggggcttg tcagcgagta taaaaaagcg 17881 actgtagacg gactgaaaac aggttctact gactctgcgg gttcatgctt tacaggaaca 17941 gctgaacgca acggtatgcg tgtcatcact gttgttttaa acgcaaaggg caaccttcat 18001 acaggccgtt tcgatgaaac gaaaaaaatg tttgattatg ctttcgacaa tttctccatg 18061 aaagaaattt atgctgaagg cgatcaagta aaaggccata aaacaatttc agttgataag 18121 ggtaaagaga aagaagtagg cattgtgaca aacaaggcgt tctctcttcc tgtcaaaaat 18181 ggtgaagaaa agaattacaa agcgaaggtc acactgaata aagacaactt aactgctcct 18241 gtgaaaaaag gaaccaaggt tgggaagctg actgcggaat acacaggtga tgaaaaggat 18301 tacggattcc ttaacagcga tctggctggc gtagaccttg ttacaaaaga aaatgtagaa 18361 aaagcaaact ggtttgtttt gacaatgcgc agtatcggcg gattttttgc cggaatttgg 18421 ggaagcattg ttgatacggt aaccggctgg ttttaatcaa ttgaaagagc tctgatggat 18481 gttagggctc tttcgcgtaa tatactgaaa aaacccaatt tttaataaaa aatgattttc 18541 aaagcgctaa aaaccgaata aaatagtata tatgcatatg aattattgga tttctaggat 18601 acaataagga ttagaaatca tataactata ccttgattag ggggaccaag aaatggctca 18661 aacaggtact gaacgtgtaa aacgcggaat ggcagaaatg caaaaaggcg gcgtcatcat 18721 ggacgtcatc aatgcggaac aagcgaaaat cgctgaagaa gctggagctg tcgctgtaat 18781 ggcgctagaa cgtgtgccag cagatattcg cgcggctgga ggagttgccc gtatggctga 18841 ccctacaatc gtggaagaag taatgaatgc agtatctatc ccggtaatgg caaaagcgcg 18901 tatcggacat attgttgaag cgcgtgtgct tgaagctatg ggtgttgact atattgatga 18961 aagtgaagtt ctgacgccgg ctgacgaaga atttcattta aataaaaatg aatacacagt 19021 tccttttgtc tgtggctgcc gtgatcttgg tgaagcaaca cgccgtattg cggaaggtgc 19081 ttctatgctt cgcacaaaag gtgagcctgg aacaggtaat attgttgagg ctgttcgcca 19141 tatgcgtaaa gttaacgctc aagtgcgcaa agtagttgcg atgagtgagg atgagctaat 19201 gacagaagcg aaaaacctag gtgctcctta cgagcttctt cttcaaatta aaaaagacgg 19261 caagcttcct gtcgttaact ttgccgctgg cggcgtagca actccagctg atgctgctct 19321 catgatgcag cttggtgctg acggagtatt tgttggttct ggtattttta aatcagacaa 19381 ccctgctaaa tttgcgaaag caattgtgga agcaacaact cactttactg attacaaatt 19441 aatcgctgag ttgtcaaaag agcttggtac tgcaatgaaa gggattgaaa tctcaaactt 19501 acttccagaa cagcgtatgc aagaacgcgg ctggtaagaa cataggagcg ctgctgacat 19561 gttaacaata ggtgtactag gacttcaagg agcagttaga gagcacatcc atgcgattga 19621 agcatgcggc gcggctggtc ttgtcgtaaa acgtccggag cagctgaacg aagttgacgg 19681 gttgattttg ccgggcggtg agagcacgac gatgcgccgt ttgatcgata cgtatcaatt 19741 catggagccg cttcgtgaat tcgctgctca gggcaaaccg atgtttggaa catgtgccgg 19801 attaattata ttagcaaaag aaattgccgg ttcagataat cctcatttag gtcttctgaa 19861 tgtggttgta gaacgtaatt catttggccg gcaggttgac agctttgaag ctgatttaac 19921 aattaaaggc ttggacgagc cttttactgg ggtattcatc cgtgctccgc atattttaga 19981 agctggtgaa aatgttgaag ttctatcgga gcataatggt cgtattgtag ccgcgaaaca 20041 ggggcaattc cttggctgct cattccatcc ggagctgaca gaagatcacc gagtgacgca 20101 gctgtttgtt gaaatggttg aggaatataa gcaaaaggca cttgtataaa acagttgaaa 20161 gctgtggaaa cttatagtac attataagca caaataaaga tcgaaaagcg ttgataggaa 20221 ctagtaggga gcctctcttt ctaagagagc cgatggttgg tgcgaatcgg tgaaagatgc 20281 tgtctgaatc catccttgag cgaaatgctg aagcgagtag gcatttacgg gataaccgtt 20341 atgtttgaaa gtggaaaacg agtctttgat ttgttttcaa tcagggtggc aacgcgagag 20401 ctctcgtccc tttatgggga tgagggctct ttttattttc gataaatcaa taaaaaaagg 20461 agtgtttcgc atgcttgata cgaaaatgct gagagcaaat tttcaagaaa ttaaagcaaa 20521 gcttgtacac aaaggcgaag acttaactga ttttgataag tttgaggcgc tggatgatag 20581 acgaagagag cttatcggca aggttgaaga gttaaaagga aaacgaaatg aagtttctca 20641 gcaggttgct gtgctgaagc gtgagaaaaa agacgcggat cacattatta aagaaatgcg 20701 tgaagtcggc gaggaaatta aaaagctcga tgaagaatta cggacagtgg aagctgagct 20761 tgatacaatc ctgctctcaa tcccgaatat tccgcatgag tctgtacctg tcggtgaaac 20821 agaagacgac aacgtagaag tgcgtaaatg gggtgaaaag ccttcatttg cttatgagcc 20881 gaagccgcac tgggatattg cggatgagct gggtattctg gattttgaac gtgctgccaa 20941 agtaacagga agccgtttcg tgttctataa aggcttaggt gctcgtctgg agcgtgcgct 21001 ttataacttt atgcttgatc tgcatgtgga tgagtataac tacactgaag tgatcccgcc 21061 atatatggta aaccgcgcaa gcatgacggg aacggggcag cttcctaaat ttgaagagga 21121 tgcatttaaa atcagagaag aagattattt cttaattcca acggcggaag tgccgattac 21181 aaacatgcat cgcgatgaaa tcctttcagg tgacagcctg ccgatcaact atgcggcatt 21241 cagtgcttgc ttccgttctg aagctggttc agcaggacgt gacacacgcg gattaattcg 21301 tcagcaccaa tttaataaag ttgagcttgt aaagtttgtg aagcctgaag attcttatga 21361 agaattagag aaacttacaa accaagcaga acgggttctt cagctgcttg agcttccata 21421 ccgtgtcatg agcatgtgta cgggtgactt aggctttacg gctgcgaaaa aatacgatat 21481 cgaagtttgg attccaagcc aagacacata tcgagaaatc tcttcttgca gcaacttcga 21541 agcgttccag gcgagacgtg cgaatattcg tttcagacgt gaagcgaaag gcaagcctga 21601 gcatgtacac acactgaacg gctcaggact ggcggttgga agaacagttg ctgctatctt 21661 agaaaattat cagcaggaag acggaagcgt tgtgattccg aaagtgcttc gtccttatat 21721 ggggaataga gaagtaatga aaccgtaaat tatggaaagg cgtgcctgac aaggtgcgcc 21781 tttttgctta tgtaaacacg gcattttcat aaaaacaaaa aaagttttta aaaatgcttg 21841 accacacgag aacatacgtg atatagttag tcttgtcgat acggaggaat acccaagtcc 21901 ggctgaaggg atcggtcttg aaaaccgaca ggggtgtcaa agcccgcggg ggttcgaatc 21961 cctcttcctc cgccatattg attttaattc taatgaaaca caagcatata ttggagattg 22021 ttttgtccgt tgcattcggt gcggcggatt ttttatttta aagaaaaagt gaatctcgac 22081 tgagattcac tttttttgat tatcatgaat aactgaagca atttgatcta caatattttc 22141 aatcgagttt tcgtcgttca gaagatcata atcttcaatg cgaagtttta aaacagggca 22201 ggcattaaaa ccgcttatcc agttctcgta gcgtgtatgc atttcttccc aataagaccg 22261 gcttgtctga agctccatct cacggccgcg ttgttcaatc cggtttaaaa tgttctccag 22321 atctccttct aaatagatca acacatctgg atgtgggaaa tacggtgtca ttaccattgc 22381 ttcgaaaagg cttgtgtaag tcttataatc aacctttgac attgtccctt tatcagcatg 22441 catttttgcg aaaattcctg tatcttcata aatcgaacga tcctgtacaa aacctccgcc 22501 ggcttcaaaa attgttttct gttctttgaa gcgttcagct aagaagtaaa tttgaaggtg 22561 aaagctccaa cgttcaaaat catgatagaa cttttccaaa tatggattat gatcgacttc 22621 ctccaacgat gttttaaatc caagccgttt agctaaagtt tttgttaaag tcgattttcc 22681 gacacctact gttcctgcta ctgtaataat tgaattctta gggatatgat gttccttcat 22741 acgataagct cctttacatg ggcggcaatg cgttcaaagt cgctcttatt caaaacgaaa 22801 tcctttgaat caccatctac ggttaacact gtaagttcag ggtctgcttc ctgcagctgc 22861 ttgatggcga cttcataatc tgaaatcagc tgctccaaat agctagtttc aatttttttc 22921 tcaaaggggc gcccgcgttt ttcaatgcgg tgtagcaatg taggcagact ggcctttatg 22981 taaatgatga aattcggctt tggcagatca tccgttagca ggtgatatat ctttttgtat 23041 ttttccagct gatgtggaga caaggttcgt tccgcaaaaa tcacattttt ataaatatga 23101 taatcagcta ttacaggctg tccctttttt aaaaagtgat cactggtgtc ttcaagctgt 23161 ttgtatctgt gacaaagaaa aaacatctcg agctggaagc tccattcctt tatattgtca 23221 taaaacttat caaggtacgg gttatcctct acaatctcat tgatcatagg gaatccgaat 23281 ttttgtgaga gcatcgttgc gagagttgtt tttcctgccc cgataggacc ttctattgca 23341 ataaaagggg ctgtattcat cggaatcctc cttatatctg aaaaacgtgc gtcagttacc 23401 gaccttcata ttgtatcaca acccttgggt gcccccatga aaaaaagacg tttccaaatt 23461 atcgaaacgt ctttttgaca acattaaatt gatcagacag cagcagccag ttttgtggaa 23521 aggaaagacc cagcttccaa tagctgatgc ctcttaaatt cagctcttta atcagattga 23581 attttgcttg aatcgagcgg gcatcctcga accatacctc gtgccttctg ttttctgcat 23641 cagtatagcg gaagaaagga gcttgagcgg tttggtcata ctgaatggaa gcattgttct 23701 gatcagctat gacaatggct tgctgagggc ttactgctct tgctggagtt ccccctgctg 23761 tatatggcag cgtccagtca tatccatata aattctggcc catgacaatt ttgttcgcag 23821 gcatttcagt caaagcatat tctatgacat cacggacagg tccaattgga gaaaccgctt 23881 gaggcggtcc gccgctatag ccccattcat atgtcatgag aacaacaaag tcgacaattt 23941 cgccatgtgc cctgtaatca tgagcttcat accacctgcc ctgctgtgtt gcacttgttt 24001 taggagcaag agccgtagaa atttctaagc cctctcgatg gaaaagatcc cttgcttcgc 24061 ggaggaattg attataggcc tctctatcct ggggccgcaa atattcaaag tcgaaatgaa 24121 tgtcacggaa gccatatctt ctggcattct cgactatttc atttagaagc cgtcttttta 24181 cagtttcgtc gttcaaaagg atccggccaa gttcatcgct gaatgcctgg ttttctaggt 24241 tcgttataat catcatcaat gttgtatttt gactttctgt aatgctcctt aaattcgtta 24301 aaggcggtgc gactaaggtt ccgttccgct gtgcctggaa gctgaatgcg ccaaggtaag 24361 ttaagtaggg cgacgcttct ctggccgcct gctggagatt ttcgctgact tgatttcctc 24421 ggggctccaa ataagcattt gattcgatgt ctcgtttagg agctggaggg atgtataaac 24481 ggaaaccaat ctgaagcacg gtatttaact ggatgcggtt aacccttgcg agctcggctg 24541 ctgttgtatt gaactgccgg gcgatggatg tcagggtatc acctcgcttc acatcataga 24601 actggccagc tattggaatg acaatggttt gtccgacaac aaggctgtcg ggattcggta 24661 tttcattcgt ttcagtgatg tcatttgtgg ttgttctgta ttgtgaagcg atagcagaaa 24721 gagtgtcgcc ttgttttacc acataaattt gaatgaaaaa cgcctccttt catatcgcta 24781 tcaatgtatg aaagaaaagc gctgatcatg tttatttttc tataatttgt tcttccgtcg 24841 taatttctgc gaaaagaaca ttctccatca tggttaaggc gaattcgtta tcttcgtcac 24901 tgtttgacgc gatacagtcc ttaggaatcg tgatgctgta ttccctcata taagcgtcat 24961 tagcggtaaa cagcacgcat atattgccgg ctatacctgt tatgataata tgtctcacct 25021 gcaactcagt aagaagggtg tgaagtgctg tttcgtagaa agcggaatgt ttcggtttga 25081 ttaaaaaata atcagcatct accggagcta tctttgtgat gatatccttg cttctttcat 25141 ttgtgcattc ttgctgtatg tttttaatgt cagcttgcca aagtccataa tgatcattga 25201 tgtaaataat cggccattca ttttgtctcg cgtgctcctt taatgataaa atatgaggaa 25261 cgattttttc tgttttttta gcgagggttt cccccatatc gaattcaaaa ttattgatca 25321 tgtctacaat gagaagggct ttatctgctt tggacaatcg acagtctcct ttccgtttca 25381 gttatagtta atatgtagcc tttttaggca atgaaaaaac tttgaaaaga gagcttatcc 25441 ttatgacaca agatgaactt tatatgaaag aagcaattaa agaagcgaaa aaggctgaag 25501 agaaaggtga agtgccaata ggtgcggtgc ttgtcattaa tggtgaaatt atagcgcgtg 25561 cgcataattt aagagagact gaacagcgat ctattgccca tgcagaaatg cttgtaattg 25621 atgaagcgtg taaggcactc ggaacatggc ggctggaagg tgcgactctt tatgtgacgc 25681 ttgagccttg tccaatgtgt gctggtgcag tcgtactttc tcgagtggaa aaagtggttt 25741 ttggcgcatt tgatccgaaa ggcggctgtt caggcacgct aatgaacctt cttcaggagg 25801 aacgctttaa tcatcaggct gaagtggtga gcggtgtgct tgaggaagaa tgcggcggaa 25861 tgctcagtgc gtttttcaga gaactaagaa aaaagaagaa agccgccagg aaaaacttgt 25921 ctgaatagta cggttgcaat ttttagggga aacagatata cttaagtgtg catcgtaata 25981 gatgcaacat aaaatttgat atttattttg ccgtgctaag cggggaggta gcggtgccct 26041 gtacctgcaa tccgctctag cagggccgaa tcccttctcg aggttcgttt actttaaggc 26101 ctgccttaag taagtggtgt tgacgtttgg gtcctgcgca atgggaattc atgaaccatg 26161 tcaggtccgg aaggaagcag cattaagtga aacctctcat gtgccgcagg gttgcctggg 26221 ccgagctaac tgcttaagta acgcttaggg tagcgaatcg acagaaggtg cacggtaaat 26281 caatcatcaa attttcagac tcacctaata ttaggtgagt tttttgttat gtaaaaagag 26341 cttttggaat cgaaacaagg ttcatgtata atgggaatga tgaataacgg aggagggcaa 26401 acccgtgagt taccaagctt tatatcgagt attcaggcct cagcgctttg aagatgtggt 26461 cggacaagaa cacattacaa aaacgctgca aaatgccctt ttgcaaaaaa agttttctca 26521 cgcctatctg ttttccgggc ctagaggaac cggaaaaacc agtgcagcca aaatatttgc 26581 taaggctgtc aactgtgaac atgctcctgt tgatgagcca tgcaacgaat gtgcggcctg 26641 taaagggata acaaacgggt caatatccga tgtcatagaa attgacgccg cttctaataa 26701 cggtgttgat gagattcgtg acattcgcga taaagtgaag tttgccccat cggccgtcac 26761 atataaggta tatatcatag atgaggtgca tatgctttct atcggcgctt ttaatgcatt 26821 actaaaaaca ttagaagagc cgcctgagca ttgtattttc atattagcaa caactgaacc 26881 gcacaaaatt cctttaacca ttatctctag atgtcagcgt tttgacttta aacgaattac 26941 ctcccaagcg attgtaggcc gcatgaataa aattgttgat gctgaacagc tgcaagtgga 27001 ggaaggatcg ctggaaatca tcgcgagtgc tgcagacgga gggatgaggg atgccctgag 27061 ccttcttgat caggccatat cattcagcgg cgatatcctg aaagtcgaag atgcgctttt 27121 aattacgggt gctgtttctc aattatatat cgggaagctt gcaaaatccc tgcatgataa 27181 aaacgtttct gacgcactgg aaacattaaa tgaattgctt cagcaaggaa aagatccagc 27241 taagctgata gaagatatga ttttctattt cagggacatg ctgctgtaca aaacagcccc 27301 tggcttagag ggagtgcttg agaaagtaaa agtcgatgaa acgttccggg aactaagtga 27361 acaaattccg gctcaggccc tatatgaaat gattgatatt ctgaacaaga gccatcagga 27421 aatgaaatgg acaaatcatc cgcgtatctt tttcgaagtg gccgttgtga agatttgcca 27481 aacctcacat caatctgctg ctgatctccc ggaagtggat atgctgatga aaaaaatcca 27541 gcagctcgaa caggaagtag agcggctcaa aacaacgggc ataaaagcag ctgcggaaag 27601 cccgaaaaaa gaagcgccgc gtgtgccaaa gggcgggaaa tccaattaca aagcgccagt 27661 aggcagaatt catgagattt tgaaggaagc cacaagaccg gatcttgatc tgctcagaaa 27721 cagttggggc aagcttcttg ctcatctcaa acagcaaaac aaagtatcac atgccgcttt 27781 gctgaatgac agtgaacctg tggctgccgg atcggcggca tttgttctga aattcaaata 27841 tgaaattcat tgtaaaatgg tcgctgagga taacaacgga gtccggacta atcttgagca 27901 gattttagaa tcgatgctcg gaaaaagaat ggatttgatt ggcgttccag aagcacaatg 27961 gggtaaaata agagaagaat ttttagaaga tcatcagcag gaaaatgaag gatcaaatga 28021 accggctgaa gaagacccgc ttattgccga agcgaaaaag cttgttggag cggatttaat 28081 tgaaataaaa gactaacaaa atgaaagaga gtgaatgcta tgcgtggcgg aatgggtaat 28141 atgcaaaaaa tgatgaaaca aatgcaaaaa atgcaaaagg acatggcgaa ggctcaagaa 28201 gagcttgcag aaaaggttgt tgaaggaact gcaggcggcg gtatggtaac agtaaaagca 28261 aacggccaaa aagaaatcct ggatgttatc atcaaagaag aagtcgttga tcctgaagat 28321 attgatatgc ttcaagattt agtgcttgct gcaacgaatg aagctttgaa aaaagttgac 28381 gaaatcacaa acgaaacaat gggtcaattt acaaagggaa tgaacatgcc aggtttattc 28441 tagggggata aaagaacatg caatatcctg aaccaatatc aaagctgatt gacagcttta 28501 tgaaattgcc agggatcgga ccgaaaacag cggttcgtct ggcttttttt gttctaggta 28561 tgaaagaaga tgtagtatta gattttgcga aagcattagt aaatgcgaaa cgcaacctga 28621 catattgttc agtttgcggg catattacag atcaggaccc ttgctatata tgtgaagata 28681 cgcgcaggga taagtctgtt atctgtgttg tgcaagaccc taaagacgtt atcgctatgg 28741 agaaaatgaa ggaatacaac ggacagtatc acgttcttca cggcgctatt tctccaatgg 28801 acggcatcgg accggaggat attaaaatac cagaattgtt aaaacgatta caggatgatc 28861 aagtgacaga agtgatcctc gcgacaaacc ctaatataga aggggaagca acagcgatgt 28921 atatatcaag gctcctcaag ccgtctggta ttaagctctc ccgtattgcc cacggactgc 28981 ccgtcggcgg tgatttggaa tatgctgatg aggtcactct ttctaaagca cttgaaggaa 29041 gacgtgaatt gtaaggagga aaaagcgatc catgggtttt cttcgcaaga aaacattaag 29101 aagagagttt gatgaaaaac taaccgagca gctttttaag caaaaggaag agtggaacag 29161 gcaaaaaaag ctggttgaaa aaagcttaga accgtctgct gaagtgttat acgaactgaa 29221 agtagctgaa gcgaagtatt ttttttactt aagggaagcg aagcagcgaa atttaaaaat 29281 cagccggtgg aagtaagtgg tctaaactcc tggatcttct cataagcttg tactagaaca 29341 agcgaaggag atgagaagat tcatggagcc tatttttatt attgggatta ttttaggact 29401 ggttattctt ctttttttat caggttcagc agcgaagcct ttaaagtgga ttggcatcac 29461 agctgttaaa tttgtggcag gtgctttgct gctggtttgt gtaaatatgt ttggcggcag 29521 tcttggcatt catgtgccga ttaatctggt tacaacagct atcagcggaa ttttaggaat 29581 acccggaata gctgcgttag tcgtcattaa gcaatttatc atttaattga tattatgtat 29641 tgacttagac aactgaaggt gttattctaa tatacgtcgc tgatgacgaa cagctttttt 29701 gaaaagaaaa tgctaaaaag ttgttgacag tagcggcggt aaatgttatg ataataaagt 29761 cgcttaaacg agcggtaaac aaagttcttt gaaaactaaa caagacaaaa cgtacctgtt 29821 aattcatttt tataaatcgc acagcaatgt gcgtagtcag tcaaactact ttatcggaga 29881 gtttgatcct ggctcaggac gaacgctggc ggcgtgccta atacatgcaa gtcgagcgga 29941 cagatgggag cttgctccct gatgttagcg gcggacgggt gagtaacacg tgggtaacct 30001 gcctgtaaga ctgggataac tccgggaaac cggggctaat accggatggt tgtttgaacc 30061 gcatggttca aacataaaag gtggcttcgg ctaccactta cagatggacc cgcggcgcat 30121 tagctagttg gtgaggtaac ggctcaccaa ggcgacgatg cgtagccgac ctgagagggt 30181 gatcggccac actgggactg agacacggcc cagactccta cgggaggcag cagtagggaa 30241 tcttccgcaa tggacgaaag tctgacggag caacgccgcg tgagtgatga aggttttcgg 30301 atcgtaaagc tctgttgtta gggaagaaca agtaccgttc gaatagggcg gtaccttgac 30361 ggtacctaac cagaaagcca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 30421 gcaagcgttg tccggaatta ttgggcgtaa agggctcgca ggcggtttct taagtctgat 30481 gtgaaagccc ccggctcaac cggggagggt cattggaaac tggggaactt gagtgcagaa 30541 gaggagagtg gaattccacg tgtagcggtg aaatgcgtag agatgtggag gaacaccagt 30601 ggcgaaggcg actctctggt ctgtaactga cgctgaggag cgaaagcgtg gggagcgaac 30661 aggattagat accctggtag tccacgccgt aaacgatgag tgctaagtgt tagggggttt 30721 ccgcccctta gtgctgcagc taacgcatta agcactccgc ctggggagta cggtcgcaag 30781 actgaaactc aaaggaattg acgggggccc gcacaagcgg tggagcatgt ggtttaattc 30841 gaagcaacgc gaagaacctt accaggtctt gacatcctct gacaatccta gagataggac 30901 gtccccttcg ggggcagagt gacaggtggt gcatggttgt cgtcagctcg tgtcgtgaga 30961 tgttgggtta agtcccgcaa cgagcgcaac ccttgatctt agttgccagc attcagttgg 31021 gcactctaag gtgactgccg gtgacaaacc ggaggaaggt ggggatgacg tcaaatcatc 31081 atgcccctta tgacctgggc tacacacgtg ctacaatgga cagaacaaag ggcagcgaaa 31141 ccgcgaggtt aagccaatcc cacaaatctg ttctcagttc ggatcgcagt ctgcaactcg 31201 actgcgtgaa gctggaatcg ctagtaatcg cggatcagca tgccgcggtg aatacgttcc 31261 cgggccttgt acacaccgcc cgtcacacca cgagagtttg taacacccga agtcggtgag 31321 gtaacctttt aggagccagc cgccgaaggt gggacagatg attggggtga agtcgtaaca 31381 aggtagccgt atcggaaggt gcggctggat cacctccttt ctaaggatat tttacggaat 31441 ataagacctt gggtcttata aacagaacgt tccctgtctt gtttagtttt gaaggaactt 31501 tgttccttga ataagttaag atgggcctgt agctcagctg gttagagcgc acgcctgata 31561 agcgtgaggt cggtggttcg agtccactca ggcccaccat cttatataac ggggccttag 31621 ctcagctggg agagcgcctg ctttgcacgc aggaggtcag cggttcgatc ccgctaggct 31681 ccaccaacgt gttctttgaa aactagataa cagtagacat cacattcaat tagtaacaca 31741 agatatcaca tagtgattct ttttaacggt taagttagaa agggcgcacg gtggatgcct 31801 tggcactagg agccgatgaa ggacgggacg aacaccgata tgcttcgggg agctgtaagc 31861 aagctttgat ccggagattt ccgaatgggg aaacccacca ctcgtaatgg agtggtatcc 31921 atatctgaat tcataggata tgagaaggca gacccgggga actgaaacat ctaagtaccc 31981 ggaggaagag aaagcaaatg cgattccctg agtagcggcg agcgaaacgg gattagccca 32041 aaccaagagg cttgcctctt ggggttgtag gacactctgt acggagttac aaaggaacga 32101 ggtagatgaa gaggtctgga aaggcccgcc ataggaggta acagccctgt agtcaaaact 32161 tcgttctctc ctgagtggat cctgagtacg gcggaacacg tgaaattccg tcggaatccg 32221 ggaggaccat ctcccaaggc taaatactcc ctagtgaccg atagtgaacc agtaccgtga 32281 gggaaaggtg aaaagcaccc cggaagggga gtgaaagaga tcctgaaacc gtgtgcctac 32341 aagtagtcag agcccgttaa cgggtgatgg cgtgcctttt gtagaatgaa ccggcgagtt 32401 acgatcccgt gcaaggttaa gcagaagatg cggagccgca gcgaaagcga gtctgaatag 32461 ggcgcatgag tacgtggtcg tagacccgaa accaggtgat ctacccatgt ccagggtgaa 32521 gttcaggtaa cactgaatgg aggcccgaac ccacgcacgt tgaaaagtgc ggggatgagg 32581 tgtgggtagg ggtgaaatgc caatcgaacc tggagatagc tggttctctc cgaaatagct 32641 ttagggctag cctcaaggta agagtcttgg aggtagagca ctgattggac taggggcccc 32701 taccgggtta ccgaattcag tcaaactccg aatgccaatg acttatcctt gggagtcaga 32761 ctgcgagtga taagatccgt agtcgaaagg gaaacagccc agaccgccag ctaaggtccc 32821 aaagtatacg ttaagtggaa aaggatgtgg agttgcttag acaaccagga tgttggctta 32881 gaagcagcca ccatttaaag agtgcgtaat agctcactgg tcgagtgact ctgcgccgaa 32941 aatgtaccgg ggctaaacgt atcaccgaag ctgcggactg ttcttcgaac agtggtagga 33001 gagcgttcta agggctgtga agccagaccg gaaggactgg tggagcgctt agaagtgaga 33061 atgccggtat gagtagcgaa agaggggtga gaatcccctc caccgaatgc ctaaggtttc 33121 ctgaggaagg ctcgtccgct cagggttagt cgggacctaa gccgaggccg aaaggcgtag 33181 gcgatggaca acaggttgat attcctgtac cacctcctca ccatttgagc aatgggggga 33241 cgcaggagga tagggtaagc gcggtattgg atatccgcgt ccaagcagtt aggctgggaa 33301 ataggcaaat ccgtttccca taaggctgag ctgtgatggc gagcgaaata tagtagcgaa 33361 gttcctgatt ccacactgcc aagaaaagcc tctagcgagg tgagaggtgc ccgtaccgca 33421 aaccgacaca ggtaggcgag gagagaatcc taaggtgatc gagagaactc tcgttaagga 33481 actcggcaaa atgaccccgt aacttcggga gaaggggtgc tctgttaggg tgcaagcccg 33541 agagagccgc agtgaatagg cccaggcgac tgtttagcaa aaacacaggt ctctgcgaag 33601 ccgtaaggcg aagtataggg gctgacgcct gcccggtgct ggaaggttaa gaggagcgct 33661 tagcgtaagc gaaggtgcga attgaagccc cagtaaacgg cggccgtaac tataacggtc 33721 ctaaggtagc gaaattcctt gtcgggtaag ttccgacccg cacgaaaggc gcaacgatct 33781 gggcactgtc tcaacgagag actcggtgaa attatagtac ctgtgaagat gcaggttacc 33841 cgcgacagga cggaaagacc ccgtggagct ttactgcagc ctgatattga atgttggtac 33901 agcttgtaca ggataggtag gagccttgga aaccggagcg ccagcttcgg tggaggcatc 33961 ggtgggatac taccctggct gtattgacct tctaacccgc cgcccttatc gggcggggag 34021 acagtgtcag gtgggcagtt tgactggggc ggtcgcctcc taaaaggtaa cggaggcgcc 34081 caaaggttcc ctcagaatgg ttggaaatca ttcgcagagt gtaaaggcac aagggagctt 34141 gactgcgaga cctacaagtc gagcagggac gaaagtcggg cttagtgatc cggtggttcc 34201 gcatggaagg gccatcgctc aacggataaa agctaccccg gggataacag gcttatctcc 34261 cccaagagtc cacatcgacg gggaggtttg gcacctcgat gtcggctcat cgcatcctgg 34321 ggctgtagtc agtcccaagg gttgggctgt tcgcccatta aagcggtacg cgagctgggt 34381 tcagaacgtc gtgagacagt tcggtcccta tccgtcgcgg gcgcaggaaa tttgagagga 34441 gctgtcctta gtacgagagg accgggatgg acgcaccgct ggtgtaccag ttgttctgcc 34501 aagggcatcg ctgggtagct atgtgcggac gggataagtg ctgaaagcat ctaagcatga 34561 agcccccctc aagatgagat ttcccattcc gcaaggaagt aagatccctg aaagatgatc 34621 aggttgatag gtctgaggtg gaagtgtggc gacacatgga gctgacagat actaatcgat 34681 cgaggactta accacatttt gaatgatgtc acacctgtta tctagttttg agagaacacc 34741 tctctaaagg cggaaggtaa ggaaactccg ctaagggctc tcacatcctg tgagaaacgc 34801 ccagtacctt catcctgaag gcatttgttt ggtggcgata gcgaagaggt cacacccgtt 34861 cccataccga acacggaagt taagctcttc agcgccgatg gtagtcgggg gtttccccct 34921 gtgagagtag gacgccgcca agcaagctta aacccagctt aatgagctgg gttttttgtt 34981 tactcaagat cgagaaaatc aaacaaatac aaacaccgag ggcttatata gcccatatac 35041 tgatttaaag tttcaaaaag gtctaaatag tgtatacaat atccgtttta aggggaggct 35101 aactgtacgg aggtggagaa gatggacgaa acagttaaac ttaatcatac atgtgtgatt 35161 tgtgatcaag agaagaatag aggcattcat ctttatacga aattcatatg cttagattgt 35221 gagagaaaag taatttctac atcaacttct gatcctgact atgcgtttta cgtaaaaaaa 35281 ctaaagagca ttcatacacc gccattatat tcatagacct gaaaaggtct ttttttgtac 35341 tcttaataat aaaaagaaga tgaaacttgt ttaaggattg aacgtagtag ataataatat 35401 taaaactgag tatagacaca ggagtcgatt atctcatgca gagatttttt cactttttgg 35461 tgtggagttt aactagcagt gcgacttttg ttttcattgg aatattgagc ttttttggtt 35521 taaaccagtc gattttttta tctattgttt atgggcttgc ttctggagca gccgtatata 35581 tagctggcat ctggaatgca agacggttat ttcttaaaaa gcatgaattg acaggaagag 35641 agtatgctta cattaagaaa aacttagagg aagcaaggca gaaaatggtc cgtcttagga 35701 aagccttgtt tcaggctaaa agcattcaaa tgtttaagca aaatgcagaa atgctaagga 35761 ttgtgagaag gatttatctc ctcaccaaaa aagagccaaa gcggttttat caggcagaac 35821 gattttttta tcaaactctc gattcggttg ttgaattgac agagaagtat gcttttctat 35881 catctcaccc aaaaaaaagc aaagaactgt cgatgtcgtt aagtgagaca cgcatcactc 35941 ttactgaatt gaccaagcgt ttagaggaag atttaactca agcaatgggt gatgaaattg 36001 acgagttgca gtttgaatta gacgcagcaa aacattcatt aaagaaataa gggaagaggg 36061 taagagcgat gaaccgagac caaagcgacc ttcatataga tgaattattg gcagatcctt 36121 ttggtggtaa catagagata ccaggttcgg aggctgtaaa agcagagaaa gagcaagtac 36181 ggcttgttga tgttcttcct gaggaaaaca aggaaaaagc aattcagctt gctggacaga 36241 ttgatcataa aaatatgcaa agcattgtct tatacggttc acaagctcaa tctaaactgc 36301 tgaacttttc tcatgatatg attaatcatg ttcaaaagaa ggatgtcggg gagattggcg 36361 aaatacttgg agagctgatg aaaaagctgg agcaagtaaa tcctgatgat ctccaatcta 36421 agaaaaaggg ttttttggca cgcatgtttg gaagagtatc aagttctctt caagaggtgc 36481 tgtctaaata ccaaaagacc agtgtgcaga tagacagaat cagcttgaag ctggagcact 36541 ctaaaaatgc tttaatcagt gacaacaagc tgttagagca gttatatgaa aaaaataaag 36601 aatatttcgc agcgctgaat gtttatattg ctgcaggaga actgaagctg gaggaattaa 36661 aaacaaaaac gattcctgaa ctgaagcaac aggctgaatc gagtgatcat aaccaaatgg 36721 ccgttcaaga ggtgaatgat ttaattcaat ttgctgaccg gttagataaa agggtgcatg 36781 atttgctgct gagcaggcaa attacaatcc aaagtgcacc gcaaatcagg ctgattcaaa 36841 atacaaacca agcgttagct gaaaagattc agtcatccat tgtgacagcg attccgttat 36901 ggaaaaatca agttgccatt gcactgacgc ttttaaggca gcgcaatgca gtggatgcac 36961 agcagaaagt atctgataca accaatgagc ttttgctgaa aaatgcggag cttttaaaaa 37021 ccaatacaat tgaaactgca cgggcaaatg aaagaggcct tgttgatata gataccttga 37081 agaaggtgca ggaaagctta ataagcacgc ttgaagaaac actgactata caagaagaag 37141 gacgaatcaa acgccgtcag gcagaagaag agctcatgat gatggaaggc gacctgaagc 37201 aaaagctgat tacaataaag gaaagatgat taccagtaag tctggcttta agttctgtca 37261 gaggcacgat ataataaggt gtaagaagac acattcaaag gattgttttc atgaacacac 37321 ctttatataa agcattaatt caacatgcga gaagaaattc tcattcattt catgttccgg 37381 gacatcacaa tggagatgtc ttttttgatg acgctaagtc aatattcgat ccgcttctca 37441 ccattgatgt aactgaactg gcaggactgg atgatctcca tcatccttct ggggtgatta 37501 aggaagctca ggagcttgcc agtcaattat atggatcggc ggaaagtttt tttctggtaa 37561 atggtacgac tgtcggaaac ttagcgatga ttttatctgt ttgtgaacct ggtgatacaa 37621 ttctggttca aagaaactgt cataaatctg tatttcatgc tgttgatttg tccggtgctg 37681 agccggttta tcttgcacct gacgttgatt cagcgatgca tgtgcctacg catgttccgc 37741 ttggaacaat taaagaggcc ctggaagcat atccagatgc gaaaggcttg gtactgacca 37801 atccgacata ttacggacat agtgctgatt tgactgagat cattactgaa gcccatcatt 37861 acgggattcc tgttttggtc gatgaagcgc atggcgcaca ttttatttta ggtgagcctt 37921 ttccggtctc agctttaaaa atgggggcag atattgttgt tcagtcggcc cacaaaacgt 37981 tgccagccat gacgatgggt tcttatttgc atctcaacag cagctgcagg attaacaggg 38041 atcgggtggc agagtattta aaccgattac aaagcagcag cccgtcttat ccgattatgg 38101 cttcgttaga tattgcccgc gcttatgtac agcatattat agaagaacaa aagctttctg 38161 acattctgca gcggatagaa acacttaaac aaacgtttga ttcacttaca aatgcagaag 38221 ctgttaaccc tgctaatcca ctgatcatca cggatccgct aaagctcaca attcgttcaa 38281 aacgcgggca ttctggctat acgctgcaaa gcattttaga gcgtgccaac atattcactg 38341 agcttgctga tgaaaatcaa gttctgctcg ttctcccatt gggaggaaaa cggagaataa 38401 acgctgaaat cattagaagc atcgatgaag agattgagaa aacgcctccg gatcagacgt 38461 ttgtttctgc agaatggggt gtgcagcctg ttactgtctt gccttatcca aaaaaggtct 38521 tacattcgtt taagaaagaa tatgtgagct ttgaggaagc agctggccgg cttaatgcag 38581 aagatatcat cccttatcct ccgggtatcc cgatgattat ggcgggagaa agaataacaa 38641 aagaaagtgt gcaaaagctc agccgcttga tcagcatgaa aacgcatgtt caagggaata 38701 tgaaaatcaa agagaaacaa ctacttgttt atatagaaga ggagaaatca tgagcggttt 38761 atttattaca ttcgaaggtc ctgaaggtgc agggaaaacg actgttctgc aggagatcaa 38821 aaacatactg acagcagaag gccttcaggt tatggcaact cgagagccag gcggaataga 38881 tattgcagaa caaattagag aggttattct gaatgagaac aatatattaa tggacccaaa 38941 aacagaagct ctcttatatg cggctgcaag acgccagcat ttagttgaaa aagtaaaacc 39001 tgctttagaa caggggttta tcgttctttg cgacagattc atagacagtt ctcttgcgta 39061 tcaaggatat gcaagagggc ttggaattga tgaggttctg tccattaatg aatttgccat 39121 tggagatatg atgccccatg taacggttta tttttcaatt gatccggaag aaggactgaa 39181 gcgtatttac gcaaacggct cacgggagaa aaacaggctc gatttagaaa aactggactt 39241 tcatacaaaa gtacaagaag gttatcaaga gctgatgaag cgatttccgg aaagatttca 39301 ttcagttgat gccgggcaat ccaaagacct cgtcgttcag gatgttctaa aggtgatcga 39361 tgaagcgttg aaaaaaattc aattgtgacc tgtttcccaa tagttgatat aataatgtaa 39421 acgagatcac gttgtttcca atctaaagga ggccttcaca gatgaaattg atagtggcag 39481 ttgtacaaga tcaggacagc aacagacttt tgaaaacctt aacggatcac aacttcagag 39541 tcacaaagct tgcaacgaca ggaggatttc ttaaatcagg caatacaacg tttatgatcg 39601 gtgtcgagga tatacgcgtc aataaagcgt tgagtctcat taaagaaaac gggcagaaac 39661 gtgatcagat gattgcccct gtatctccaa tgggtggaaa tgctgattcc tatgtccctt 39721 atccagtcga agttgaagtt ggcggagcga cagtatttgt ccttccagtc gatgaatttc 39781 atcaatttta aggatctgaa actgtgaaaa ttaataaaga tatacgtaca tttatagata 39841 ataagcagat tccctctgtg aaaacatctg agatcacagc atcgtttaaa acatcaatgg 39901 aaaaccaaag cagcaaaatg aagcttgatc agcttaccag gctgttatct gatatagaag 39961 catttggaaa aaggctaacg aaatctcgga attttaaaga cttagcgaga tttaaaggac 40021 ttgtgaaacg ttttgtcaaa gaagctgtgg acagcggtct ttcacatgaa acatcgaaaa 40081 gctttgacct ttacgggaac agcagaacgc tgggacttgt gaaagaaata gatgacaaat 40141 tgatacagct tacggaagag atgatggatc aggaaaaacc ggcaattgat ttgctggagc 40201 gtattggcga aataaaaggt ttattaatta acctttacac atagagagtg atacaatggc 40261 aatatcctgg aaggaaatga acgagcttca gcccagagtg atgaagcttt tatataatag 40321 tattgagaag gacagactat cacacgctta tttgtttgag gggaaaaaag gaacaggcaa 40381 gcttgatgcc gcgctgcttc ttgcaaaaag cttcttttgt ctggagggtg gcgcggagcc 40441 ttgtgagagc tgccgaaact gtaaacggat agagtcaggg aaccatcctg atctccatct 40501 tgttcagcct gatggcttat caatcaaaaa ggcgcaaatt caagcgctcc aagaagagtt 40561 ttctaagaca ggacttgaat cgcataaaaa gctgtatatt atttcgcacg cagatcaaat 40621 gacagcaaat gcggcgaaca gcctgctgaa atttttagaa gaaccgaaca aagacacaat 40681 ggccgtcctc atcactgagc agccccaaag gttattggat accatcattt caagatgcca 40741 aacccttcct tttcagcctt tgcagccgaa agcaattgaa gacagactga tcgaacagga 40801 cgtctcgcct catatggcaa ggcttctggc caacatgact aataatgtag cagaagcagt 40861 cgaattaagt cgaaatgatg agtttgcaga gtctagagcg aaagtgataa aattgtatga 40921 agtcctacac cagcggaaag gacatgcttt tttctttatt caagatcaat ggatgccctt 40981 tttcaaagaa aaaacccatc aagaaatggg tcttgatatg ctcttattga tatatcgtga 41041 tgtgttgtcc atccaaatag gaaatgaaga taaattgatt tatcaagact tattccaatc 41101 aataaaacag catgcgctac aatcaacaca acaaagcgtt acgaatcaga tacttgctgt 41161 tttagaagca aagaaacggc ttcattccaa tgtgaatgta caaggattaa tggagcactt 41221 ggtgttaatg ttgcaggagg gataagcttg tacaatgtaa ttggtgtccg ctttaagaaa 41281 gcgggtaaaa tatattattt tgatccgaat ggatttcata tagaacatga cagctgcgta 41341 attgtagaaa ctgtcagagg cgttgagtac ggccaggtcg taattgcaaa taaacaggtg 41401 gatgagcatg atgtggtgct tccccttcga aaagtgatac gtgtggcaga cgatcgcgat 41461 cttctcattg tagaagaaaa taaacaggaa gcactatcag catttgatat ctgccaaaag 41521 aaagtgattg agcatggctt ggatatgaag ctggtcgatg ttgaattcac gtttgatcgc 41581 aataaagtca ttttttactt cactgctgac ggccgagtcg actttagaga gcttgtaaag 41641 gatttggctt ctatctttaa gacaagaatt gagctgcgcc aaatcggagt gagggatgag 41701 gcaaaaatgc tcggaggaat cggtccttgc ggaagaatgc tttgctgttc aacgtttctt 41761 ggagattttg aacccgtttc cattaaaatg gccaaggatc agaacttgtc tttaaatcct 41821 acgaagattt cgggtctttg cggacgattg atgtgctgtc taaaatatga gaacgatgag 41881 tatgagacgg caaaagaaca gcttccggat ataggagaaa tgattacgac agcaaacggt 41941 cccgcgaagg tcgtcggact aaatattctg gaacgggtgc ttcaggtgga actgataaac 42001 cgtgaaaaag tgatagaata tacttgggaa gagctcttgg aagagggcgt cgtatccgca 42061 caaaccacag attaacgagg tgtggaacct tggataaaaa agagttattt gatacagtca 42121 ttaacttaga agaacaaatt ggctcactgt accggcagct gggggatttg aagcagcata 42181 tcggtgagat gattgaggaa aatcatcatt tacagcttga aaacaagcat ttgcgcaaac 42241 ggctggacga tacgacgcag cagattgaaa agttcaaagc tgataaaaaa gaatcaaaaa 42301 cacagaagac agagcaaact gatatagggg aaggatatga taatctggca cgtctgtatc 42361 aagaaggatt tcatatctgc aatgtccact atggaagtgt tcgaaaagag gattgtcttt 42421 tctgtctgtc attcttaaat aaaaaatagg gaaaaggctt ccgcataaga cgggagcctt 42481 tttcaaaggt actgaaagga taagaagatg gtttcattac atgatgatga aagattagat 42541 tatttgctgg cagaggacat gaaaatcata caaagcccaa cagtgtttgc tttttcgttg 42601 gacgctgtgc ttctgtccaa atttgcgtac gttccgattc aaaaagggaa aattgttgat 42661 ttatgcaccg gcaatggtat tgtgccgctg ctgctcagta caagatcaaa agcagacatt 42721 ctgggagtcg aaattcaaga aagactgcat gatatggctg ttcgcagcgt ggagtataat 42781 aagttggacg atcagatcca gatcatacat gatgacctga aaaacatgcc ggagaaactt 42841 ggacataatc gatatgatgt tgtcacctgc aatccgccgt attttaaaac gccgaaacaa 42901 actgaacaaa acatgaacga gcatctccga atcgcaagac atgaaatcca ctgcacgctg 42961 gaggatgtca tttcagtcag cagcaagctg ctcaagcaag ggggaaaagc agctcttgtt 43021 caccggccgg gaaggcttct ggagattttt gaactgatga aggcttatca aatcgagccg 43081 aaacgtgtac aatttgtcta tccgaagcaa gggaaagaag ccaataccat tttggttgaa 43141 ggtatcaaag gcgggcgccc ggatttgaaa attcttcctc ccttattcgt atatgatgaa 43201 caaaatgaat atacaaaaga aatcaggacc attttatatg gagacaaata accatttctt 43261 ctacgtcgtg aaatgtaagg acaatagctg gtatgccggg tataccaacg atctgcataa 43321 acgagtgaaa acgcacaatg atggaaaggg cgcaaagtac acaaaagtaa gacgtccggt 43381 tgaattaatt tttgccgaga gcttttcaac aaagcgggaa gctatgcagg cggaatatta 43441 tttcaaaaaa ctaactcgga agaaaaaaga gctttatata gaagaaaagc ggaacagcaa 43501 ggaggctgta tatgttaagg cgccaaatga gctttaatgg aaagtcggac atggggattc 43561 tttacttggt cccaacccca atcggaaatt tagaggatat gacattccgg gcgatcgaca 43621 cgctgaaatc agtggatgcg attgctgcgg aagatacgag gcaaacgaaa aagctttgtc 43681 atgtatatga aattgaaaca ccgctcgtca gctatcacga acacaataaa gaaagcagtg 43741 ggcacaaaat tattgaatgg ctgaaatcgg gaaaaaacat tgctcttgtc agtgatgccg 43801 gtctgccgac gatttctgat cccggagcgg aaattgtaaa ggattttacg gatataggcg 43861 gttatgttgt tccgttgccg ggagcaaatg ctgcattaac agctcttatt gcttcaggta 43921 ttgtaccgca gccttttttc ttttacggtt ttctcaacag acagaaaaaa gaaaagaaga 43981 aggagcttga agcccttaaa aaacggcagg aaacgatcat tttttatgaa gcgccccaca 44041 gattgaagga aaccttgtca gcgatggcag agatattagg agatcgggaa attgctgtaa 44101 cacgtgaact cactaagaaa tatgaagagt ttatccgagg aaccatatct gaggtcattg 44161 gatgggcaaa cgaggatcag atacgcggcg agttttgtct tgtcgtagaa ggaagtaata 44221 atgaagaggt agatgaggaa gaacaatggt gggaaaccct cactgcgaaa gaacatgtcg 44281 agcattacat ttcgaaaggc gctacgtcta aagaagctat taaaaaagca gcagtcgatc 44341 gcaatgtacc aaagcgtgaa gtgtacgatg cttaccatat taagcaataa aaaaacgttc 44401 ttgtgtcata acaagaacgt tttttgtaca agaaatgatt atttaaggtt ttgaagctgg 44461 ttttggattt cgctgatgat ttgctcagcg ccttctttac taagaaccaa tttaccgcct 44521 gcaagtttaa ggttatcatc agaaacttca ccagttactt ggcaagtcat gtttggttta 44581 tattttttaa ggatgatttt ttcatcatca acatagattt caagagcatc tttttctgcg 44641 attccaagag tacgacgcag ttcgatagga ataactacac gtcctaattc atcaacttta 44701 cgtacaatac cagtagattt cataaacatt ctcctcccaa gagatactta tttgtttaaa 44761 ttatattttt cttcgtcatt attcgacaaa atccttacct tcatagcata acaaggtttc 44821 caataatcgt caatcatttt gtttactatt gattgtaaga attagttctt atagtcagta 44881 atgtcttgga aactaccgaa ataacagcat tttataaata tttaataaag ctattatcct 44941 actaaaaatc cttttaaatc aagactttcg aaccaaagtt ttttatttca tttgattata 45001 tacgacaaaa ttcgacacga acagactttt tttattttca ttaaagattt ttaattttaa 45061 ttattctttt tcagggcgta tgtatatatt cttgatctta aaggctaaga tggtatcata 45121 gataaaggat aaatataaat aatattcata tatgatttgc acttatcgcc gctctcgtcc 45181 tttgggcggg agctttttga cattctgatt aggaggtttc aagatgccgc aagaaaacaa 45241 tacattttac attacaacac cgatttatta tccgagcgga aaattacata tcggccatgc 45301 atatacgaca gtcgcaggag atgcaatggc acgttacaaa agattaaaag ggttcgatgt 45361 tcgctattta acgggaacgg acgagcatgg acaaaagatc cagcaaaaag ctgaacagga 45421 aaacattaca cctcaggagt atgtggatcg cgcagcggca gatattcaaa aactgtggaa 45481 gcagcttgaa atctcaaacg acgactttat ccgcacgaca gaaaaacggc ataaagttgt 45541 cattgaaaaa gtgtttcaaa agcttcttga taacggggac atctatcttg atgagtatga 45601 aggctggtac agcatccctg atgaaacgtt ctacacggaa actcagctcg ttgatattga 45661 gcggaatgaa aagggagagg tcatcggcgg aaaaagccct gacagcggtc acccagttga 45721 attgatcaaa gaggaatctt atttcttccg catggggaaa tacgcggatc gtcttctgaa 45781 atactatgaa gaaaacccga cattcattca gccagaatca cgcaaaaacg aaatgattaa 45841 taactttatc aaacctggac ttgaggattt ggcagtatca cgtaccactt ttgattgggg 45901 cgtgaaggtg ccggaaaatc caaagcatgt tgtatatgtt tggattgacg cactatttaa 45961 ctatttaacg gcactcggtt atgatacaga aaatgatgag ctttatcaaa aatattggcc 46021 tgccgatgtt catttagtcg gtaaggagat tgtacgattc catactattt actggccaat 46081 tatgctgatg gcgctggatc ttccgctgcc aaagcaagta ttcgcgcatg gctggctttt 46141 gatgaaagac ggaaaaatgt cgaaatcaaa aggaaacgtt gtagatccgg ttacattaat 46201 tgaacgctat ggtttagacg aacttcgcta ttacttgctt cgcgaagtgc cgttcggatc 46261 agacggtgtt ttcacgccgg aaggatttgt tgagcgaatc aactatgatt tagcgaatga 46321 tttaggaaat ctattgaatc gtactgttgc gatgattaat aagtattttg acggacaaat 46381 cggttcttac aaaggtgctg ttacggaatt tgaccatacg ctcacttctg ttgctgaaga 46441 aacagtgaaa gcttatgaga aagcaatgga aaatatggag ttctcggtag cactttcgac 46501 tttatggcag ctcatcagcc gcacaaacaa atacattgat gagacagctc catgggtgct 46561 tgcgaaagat ccggcaaaag aagaagaatt gcgatcagtt atgtatcatc tcgctgaatc 46621 attgcgtatt tcagcggtac tgcttcagcc attcttaaca aaaacacctg aaaaaatgtt 46681 cgagcagctg ggcattactg atgaatcttt aaaagcttgg gacagcatta cagctttcgg 46741 ccagctgaaa gatacaaaag tacaaaaagg cgagccattg ttccctcgtt tagaggcaga 46801 agaagaaatt gcttacatca aagggaaaat gcaaggttca gcaccagcga aagaagaaac 46861 aaaagaagaa gagcctcaag aggtcgatcg tttacctgaa attacgattg atcaatttat 46921 ggatgtagag cttcgcgtag ctgaggtcat tgaggcagag ccagtgaaaa aagcagaccg 46981 tttattgaag ctgcagcttg atcttggttt tgaaaagcgc caagtggtat ccggcattgc 47041 gaagcattat acgcctgaag agcttgttgg aaaaaaactc gtttgtgtaa caaatctaaa 47101 accggttaaa ctcagaggag agctttctca aggtatgatc cttgcaggag aagcagacgg 47161 cgttttaaag gtcgtatcta tcgatcagtc gttaccaaaa ggcacaagaa ttaaataatg 47221 ataaacaaaa ggtgtttcac gtgtaacaat tcgtcgaaca ccttttgtgt ttcgacaaga 47281 aaggagtttt tcacttatgt tgtttgacac tcacgcgcat ttaaatgcag aacaatatga 47341 tactgatctt gaagaggtta ttgaacgggc aaaagctgaa aaagttgaac gaattgtcgt 47401 agttggtttt gaccgtccga cgattacccg tgcgatggaa atgattgagg aatatgattt 47461 tatttatgca gccattggct ggcaccctgt tgacgctatt gacatgacag aggaagactt 47521 agcgtggatt aaagagcttt ctgctcatga gaaagtggta gcgatagggg aaatgggact 47581 ggattatcat tgggataaat cacctaaaga tattcaaaaa gaggtgttta gaaatcaaat 47641 cgccttagcg aaagaggtca atttgcctat tatcattcat aaccgtgatg caacggagga 47701 tgtcgtgacc attttgaaag aggaaggcgc agaagctgtg ggcggaatca tgcactgctt 47761 tacaggaagt gcggaagtgg caagagaatg catgaaaatg aatttttatt tatcatttgg 47821 gggaccggtg acatttaaaa atgcgaagaa accgaaggaa gtagtgaagg aaattcccaa 47881 tgaccggctg ctgattgaaa cggactgccc gtttctcaca ccgcaccctt tccgcgggaa 47941 aagaaatgag ccaagctatg tgaaatatgt ggcagaacaa atcgccgaat taaaagaaat 48001 gacctttgaa gagattgctt ccatcacgac tgaaaatgcg aaaagacttt tccgtataaa 48061 ctgacaaaaa acgctagcgg gttttgtaag agcttgtccc ttacagcgtt tttctataaa 48121 agttctacat gctttcttct cctcatagga taggtttgtc gacaagtctt tcttccgttt 48181 ctcagtgtat ttcaggataa tgaagaggac actgagcttt tgggagaaag agaagggagg 48241 gttgacagcc ttttagatac tctatataat ctctccgagg agaaggaggc gtttttcatc 48301 acacaaaaaa tgaaaaagct gttttccgta aagcttagca aaagcaaagt cattctggtt 48361 gctgcttgtt tgcttttggc aggaagcggg actgcgtacg cggctcatga gctgacgaaa 48421 caatcagtct cagtttctat caatggcaaa aagaaacata tacgcacaca tgcaaataca 48481 gtcggtgatc ttttggagac gcttgatata aagacaagag acgaagacaa gatcacacct 48541 gctaaacaga caaagataac agcagacatg gacgttgtgt atgaggctgc aaaacctgtg 48601 aagcttacaa taaacgggga agaaaagacg ttatggtcaa cagcaaaaac ggtcggtgca 48661 ttactggacg aacaagatgt tgatgtgaaa gaacaagatc aaattgatcc cgcaatagat 48721 acagatattt cgaaagacat gaagattaac atagagcccg catttcaggt tactgtgaat 48781 gatgcaggga aacaaaagaa gatctggacg acttcgacta cggtcgctga ctttttaaaa 48841 cagcaaaaga tgaacataaa agacgaagat aaaatcaagc ctgcgttaga tgcaaagctg 48901 acgaaaggaa aggctgatat tacaattact cgtatcgaaa aggtcaccga tgtagttgaa 48961 gagaagattg cgttcgatgt gaaaaagcaa gaagacgctt ctcttgaaaa agggaaagaa 49021 aaggtcgtcc aaaaaggaaa agaaggcaag ctaaaaaaac atttcgaagt cgttaaagaa 49081 aacggtaaag aagtgtccag agagcttgta aaagaagaaa cagctgaaca aagcaaagat 49141 aaagtgattg ctgtcggcac aaagcaaagc agtccaaaat ttgaaacggt cagtgcttca 49201 ggtgattcaa aaacagttgt gtcccgcagc aatgaatcaa caggcaaagt catgactgta 49261 tcatctacgg cttatacggc aagctgcagc ggttgttcag gacatacagc gacaggcgtc 49321 aatttaaaaa ataatccgaa tgccaaagtc atcgctgtgg atccaaatgt cattccgcta 49381 ggctccaaag tccacgtgga aggctatgga tatgccattg ctgcagatac cggttcagcg 49441 attaaaggga acaagataga cgtctttttc ccagagaaat catcggcgta ccgatgggga 49501 aataaaacag tcaaaattaa aatcttaaat tagtatatac ttatgtattc agagggtttt 49561 gcgccctctg tttttttcgt tataatagac aaagtgcatt ttctgcttat tagacgctcg 49621 atataagaaa aagtttcatg aatatacaaa agtttttatt ttgtcttgga ggaaataatg 49681 aaaattaaag agatcattgt ggtcgagggg cgtgacgata cggcccgcat caaattggct 49741 gttgatgcag acacaattga aacaaatggt tcagccatcg atgatcatgt gattgaccaa 49801 atccgtttgg cccagaagac gagaggcgtc attattttaa cggatccgga ctttccggga 49861 gagaagattc gcaaaaccat ctcagaggct gtacccggct gtaagcatgc atttttgcca 49921 aaacatcttg ccaaacctaa aaacaagcgg ggaattggtg tggagcatgc atcggttgaa 49981 agcattaggg catgtttaga aaatgtgcat gaggagatgg aagcgcagcc gagtgacatt 50041 tcagctgagg atttgattca tgccggacta ataggcgggc ctgcggccaa atgccgccgg 50101 gaacgactgg gtgatctgtt gaaaatcggc tatacaaatg gcaaacagct tcaaaaacgg 50161 ctgcaaatgt ttcaaattaa aaaaagtgat tttatgagtg cgctcgatac cgttatgcgg 50221 gaggaacaga atgaataaag atattgcgac accgattaga acgaaagaga tactgaagaa 50281 atacggtttt tcttttaaaa agagcttagg acagaatttc ttaattgata cgaacatttt 50341 aaacagaatt gttgatcacg cggaagtgac ggagaaaaca ggtgtcattg aaatcggccc 50401 gggaatcggg gctttaaccg aacagcttgc caagcgggcg aaaaaggtcg tggcatttga 50461 gattgaccag cgattattgc cgattctgaa ggatacactg tcaccttacg aaaatgtcac 50521 tgtcattcat caggacgtgt taaaggctga tgtcaaatca gtcattgaag aacaatttca 50581 agattgtgat gagatcatgg tagttgccaa ccttccttat tacgtaacaa caccgattat 50641 catgaaactg cttgaagaac atcttccgct gaaagggatt gtggttatgc tgcaaaaaga 50701 agtggctgag cgcatggcgg ctgatccttc atctaaggaa tacggctcgc tttcaatcgc 50761 ggtgcagttt tatacagaag ccaaaacggt gatgatcgtc ccgaaaaccg tatttgttcc 50821 tcagcctaat gtcgattccg cagtcattcg tctgattctc cgagacggcc cggcagtgga 50881 cgtggaaaac gaatcctttt tctttcagct catcaaggca agctttgcac agcgccgtaa 50941 aacgctgctc aataacttag ttaacaatct gcctgaagga aaagcacaaa aatcaacgat 51001 tgaacaagtg ctcgaagaaa caaatattga cggtaagcgc cgaggtgaat ccctgtctat 51061 tgaggaattc gcagcgctgt ctaacggatt gtataaagcc cttttctaaa agggcttttt 51121 gttttgcgca ccacatggac tgccgctaca taggctagag aaggaccttt cattcaatga 51181 taagaaaaaa cttggactca gcgaaaaaag gcgctttctc aaggctcttt ctttcatgat 51241 gaggcttagt ctatgtgtgg agtgaggaac gtgcaatttc aaatagggga tatggtagcc 51301 agaaaatcct atcagatgga tgttttgttt cgaattatag gaatagagca aacaagcaaa 51361 ggaaattcaa ttgccatttt gcatggagat gaagtcaggc tgattgctga ttcggatttt 51421 tctgatctgg tggcagtgaa aaaggatgag cagatgatgc ggaaaaagaa agatgagagc 51481 agaatgaatg agtcgctcga attgctccgc caagattata agctgctcag agaaaagcag 51541 gagtactatg cgacaagcca atatcagcat caggagcatt atttccatat gccgggcaaa 51601 gtgcttcatc tggatggtga cgaagcatat ttgaaaaaat gcctgaatgt ctataaaaaa 51661 attggagtgc cggtctatgg catccattgc catgaaaaga aaatgtctgc ttctattgaa 51721 gtattgctcg acaaatatcg acctgacatc ctggtgatca cagggcatga tgcgtactcg 51781 aagcaaaagg gcggtattga tgatttgaat gcgtacagac attctaagca ctttgttgaa 51841 acagttcaaa cagcccgaaa aaagatccct cacttagatc agcttgttat ttttgcgggg 51901 gcctgccaat cccattttga atcactcatc agagcgggtg cgaattttgc aagttcaccg 51961 tcaagagtca atattcatgc gcttgatccg gtatatatcg tcgcgaagat cagctttacg 52021 ccgtttatgg aacggattaa tgtatgggaa gtgctccgta atacgctgac aagagagaaa 52081 gggcttggag gtattgaaac aagaggagtt ctgagaattg gtatgcctta taagtccaat 52141 taacagttga aaacctgcat aggagagcta tgcgggtttt ttattttaca taatgataca 52201 taatttaccg aaacttgcgg aacataattg aggaatcata gaattttgtc aaaataattt 52261 tattgacaac gtcttattaa cgttgatata atttaaattt tatttgacaa aaatgggctc 52321 gtgttgtaca ataaatgtag tgaggtggat gcaatggcga agacgttgtc cgatattaaa 52381 agatcgcttg atgggaattt aggtaaaagg ctgacgttaa aagcaaacgg tggccgccga 52441 aaaacgattg agcgttcggg cattttagct gagacgtacc cttctgtttt tgtgatacaa 52501 ctagatcaag acgagaactc gtttgaaaga gtttcataca gttatgctga tattttgact 52561 gagactgttg agctgacatt taatgatgac gccgcaagct cagtggcatt ttaacgggca 52621 gtgaaccttt tgtttactgc tttttgtttt gccctttttt ggtttccaat aattttaacg 52681 aaagttccat ctgatttaac aaaagataaa acagtcacat attatcgtga cgtgcacgaa 52741 tggctatcac ttctaaaaaa ggagttgttt cgtttgggca gacgtcgtgg agttatgtca 52801 gatgagttta aatatgagct ggctaaagac cttggttttt atgacacagt aaaaaatgga 52861 ggctggggtg aaattcgggc ccgcgatgcc ggtaacatgg tgaagcgtgc tattgaaatc 52921 gccgaacagc aaatggctca gaatcagaat aaccgataag gatgtgaccc gggggacgtg 52981 ctgttccctg gtttttttat tttggatata aatacataat gggctgaata tggatatgtt 53041 catcctgtac ttcaaatgtg atacaatgtt catacttatg tttagatgga gaagtaggtg 53101 aaagctatgc gtattttaga aaaagcgcca gctaagatca atctgtcact tgacgtcacc 53161 cgaaaacgcc cggatggcta tcatgaagtc gaaatgatca tgacgacaat tgatttagct 53221 gatcgaattg aattgacgga gcttgcagag gatgaagtga gggtttcctc ccacaaccga 53281 tttgtgcctg atgaccaaag aaacttagct tatcaggctg ccaagctgat caaggacaga 53341 tacaacgtga aaaagggagt ttccatcatg attacgaagg taattccggt ggctgccggt 53401 cttgccggcg gaagcagtga tgcggcggcg acactcagag ggctgaacag actgtggaat 53461 ttaaatctgt ccgcggaaac gcttgctgag cttggagcgg aaattggctc tgacgtttca 53521 ttttgtgtct atggcggaac tgcattagca acagggcgcg gcgagaaaat taaacatatc 53581 agcacgcctc cgcactgctg ggtcatttta gcgaagccga caatcggtgt ttcaactgct 53641 gaagtgtaca gagcgctgaa actggatggt atagagcatc ccgatgtaca aggcatgatc 53701 gaggcgatag aagaaaagag ttttcagaag atgtgcagcc ggttaggcaa tgtgcttgaa 53761 tctgttacac tcgatatgca tcctgaagtt gcgatgatca aaaaccagat gaaacgcttt 53821 ggtgcagatg ccgtgttaat gagcgggagc ggcccgacag tgtttggact ggttcagtat 53881 gagtcgaagg tgcagagaat ttataacggg ttaagaggct tctgcgatca agtttatgcg 53941 gtgagaatga tcggcgaaca gaacgctctt gattaaatcc gtatgttaag ttatattgat 54001 cttaaaatat tcggattttg ggggtgagtt catgaagttt cgtcgcagcg gcagattggt 54061 ggacttaaca aattatttgt taacccatcc gcacgagtta ataccgctaa cctttttctc 54121 tgagcggtat gaatctgcaa aatcatcgat cagtgaagat ttaacaatta ttaaacaaac 54181 ctttgaacag caggggattg gtactttgct tactgttccc ggagctgccg gaggcgttaa 54241 atatattccg aaaatgaagc aggctgaagc tgaagagttt gtgcagacac ttggacagtc 54301 gctggcaaat cctgagcgta tccttccggg cggttatgta tatttaacgg atatcttagg 54361 aaagccatct gtactctcca aggtagggaa gctgtttgct tccgtgtttg cagagcgcga 54421 aattgatgtt gtcatgaccg ttgccacgaa aggcatccct cttgcgtacg cagctgcaag 54481 ctatttgaat gtgcctgttg tgatcgttcg taaagacaat aaggtaacag agggctccac 54541 agtcagcatt aattacgttt caggctcctc aaaccgcatt caaacaatgt cacttgcgaa 54601 aagaagcatg aaaacgggtt caaacgtact cattattgat gactttatga aagcaggcgg 54661 caccattaat ggtatgatta acctgttgga tgagtttaac gcaaatgtgg cgggaatcgg 54721 cgtcttagtt gaagccgaag gagtagatga acgtcttgtt gacgaatata tgtcacttct 54781 tactctttca accatcaaca tgaaagagaa gtccattgaa attcagaatg gcaattttct 54841 gcgttttttt aaagacaatc ttttaaagaa tggagagaca gaatcatgac aaaagcagtc 54901 cacacaaaac atgccccagc ggcaatcggg ccttattcac aagggattat cgtcaacaat 54961 atgttttaca gctcaggcca aatccctttg actccttcag gcgaaatggt gaatggcgat 55021 attaaggagc agactcatca agtattcagc aatttaaagg cggttctgga agaagcgggt 55081 gcttcttttg aaacagttgt aaaagcaact gtatttatcg cggatatgga acagtttgcg 55141 gaagtaaacg aagtgtacgg acaatatttt gacactcaca aaccggcgag atcttgtgtt 55201 gaagtcgcga gactcccgaa ggatgcgtta gtcgagatcg aagttattgc actggtgaaa 55261 taataagaaa agtgattctg ggagagccgg gatcactttt ttatttacct tatgcccgaa 55321 atgaaagctt tatgacctaa ttgtgtaact atatcctatt ttttcaaaaa atattttaaa 55381 aacgagcagg atttcagaaa aaatcgtgga attgatacac taatgctttt atatagggaa 55441 aaggtggtga actactgtgg aagttactga cgtaagatta cgccgcgtga ataccgatgg 55501 tcgcatgaga gcgattgcat ccatcacgct ggatcacgaa tttgttgtac atgatattcg 55561 tgtgattgat ggaaacaatg gtcttttcgt tgcgatgccg agtaaacgca cccctgatgg 55621 agagttccgc gatattactc atcctattaa ttcaagcacg cgaggaaaga ttcaagatgc 55681 cgtgttaaat gagtatcatc gtctgggtga cactgaagca ttagaattcg aagaagctgg 55741 agcttcttaa aaaataacca aaaagcaagg actgctgaaa gggctgacat aagccttttg 55801 ccggcggtcc ttttttaatt ctgatttttc aaacttagtt gcactcaata gaaaattctt 55861 gcacttcatg aagtctcctt gaaatcagaa gatatttagg atatattttt ctatggataa 55921 aagggatatt ggaggccaat aaatggataa gcggtttgca gttgttttag cggctggaca 55981 aggaacgaga atgaaatcga agctttataa agtccttcat ccagtttgcg gtaagcctat 56041 ggtagagcac gtcgtggacg aagccttaaa attatcttta tcaaagcttg tcacgattgt 56101 cggacatggt gcggaagaag tgaaaaagca gcttggtgat aaaagcgagt acgcgcttca 56161 agcaaaacag cttggcactg ctcatgctgt aaaacaggca cagccatttc ttgctgacga 56221 aaaaggcgtc acaattgtca tttgcggaga tacgccgctt ttgacagcag agacgatgga 56281 acagatgctg aaagaacata cacaaagaga agcgaaagct acgattttaa ctgcggttgc 56341 agaagatcca actggatacg gccgcattat tcgcagcgaa aacggagcgg ttcaaaaaat 56401 agttgagcat aaggacgcct ctgaagaaga acgtcttgta actgagatca acaccggtac 56461 gtattgtttt gacaatgaag cgctatttcg ggctattgat caggtgtcta atgataatgc 56521 acaaggcgag tattatttgc cggatgtcat agagattctt aaaaatgaag gcgaaactgt 56581 tgccgcttac cagactggta atttccaaga aacgctcgga gttaatgata gagttgctct 56641 ttctcaggca gaacaattta tgaaagagcg cattaataaa cggcatatgc aaaatggcgt 56701 gacgttgatt gacccgatga atacgtatat ttctcctgac gctgttatcg gaagcgatac 56761 tgtgatttac cctggaactg tgattaaagg tgaggtgcaa atcggagaag atacgattat 56821 tggccctcat acggagatta tgaatagtgc cattggcagc cgtacggtta ttaaacaatc 56881 ggtagtcaat cacagtaaag tggggaatga tgtaaacata ggaccttttg ctcacatcag 56941 acctgattct gtcatcggga atgaagtgaa gatcgggaat tttgtagaaa ttaaaaagac 57001 tcaattcgga gaccgaagca aggcatctca tctaagctat gtcggcgatg ctgaggtagg 57061 cactgatgta aacctgggct gcggttcaat tactgtcaat tatgatggaa agaataagta 57121 tttgacaaaa attgaagatg gcgcgtttat cggctgcaat tccaacttgg ttgcccctgt 57181 cacagtcgga gaaggcgctt atgtggcggc aggttcaact gttacggaag atgtacctgg 57241 aaaagcactt gctattgcca gagcgagaca agtaaataaa gacgattatg tgaaaaatat 57301 tcataaaaaa taatcctaaa ttcggaggtt tatccatgtc taatcaatac ggagataaga 57361 atttaaagat tttttctttg aattcgaatc cagagcttgc aaaagaaatc gcagatatag 57421 ttggagttca attagggaaa tgttctgtca caagatttag tgacggggaa gtccaaatta 57481 atatcgaaga aagtattcgc ggatgtgatt gttacatcat ccagtctaca agtgaccccg 57541 ttaacgagca tattatggaa ctgctgatta tggtagatgc gttaaaacgc gcttctgcaa 57601 aaacgattaa cattgttatt ccttattacg gttatgcgcg tcaagacaga aaagcaagat 57661 cccgtgagcc aatcacagct aaacttttcg ctaacctgct tgaaacagcc ggtgcgactc 57721 gtgtgattgc acttgacctg catgcgccgc aaattcaagg attctttgat ataccgattg 57781 accacttaat gggtgttccg attttaggag aatattttga aggcaaaaat cttgaagata 57841 tcgtcattgt ttcaccagac catggcggtg tgacacgtgc ccgcaaactg gctgaccgac 57901 taaaagcgcc aattgcgatt atcgataaac gccgtccgcg tccaaacgtg gcggaagtca 57961 tgaatattgt aggtaacatc gaagggaaga ctgctatcct catcgatgac attattgata 58021 ctgcaggtac gattacactt gctgctaatg cgctcgttga aaacggagcg aaagaagtat 58081 atgcatgctg tacacaccct gtactatcag gccctgcggt tgaacggatt aataattcaa 58141 caattaaaga gcttgttgtg acaaacagca tcaagcttcc tgaagaaaag aaaattgaac 58201 gctttaagca gctttcagtc ggaccgcttc tggccgaagc gattattcgc gttcatgagc 58261 agcaatcagt cagctatctg ttcagctaaa ccatttttcg aggtttaaat ccttatcgtt 58321 atgggtattg tttgtaatag gacaactaaa acgacaagag gatggtgctg aatatggcaa 58381 ctttaacggc aaaagaaaga acggacttta ctcgttcgtc tcttcggaat atccgtactt 58441 caggacatgt tccaggtatc atatatggga aggatacggg taacaaacct gtgtcattag 58501 acagtgtgga gctcatcaaa acgctgaggg acgaaggcaa aaatgcagtc attacgcttg 58561 aggtcagcgg agaaaaacac tcagtcatgg taacagacct gcagacggac ccgctgaaaa 58621 atgaaatcac tcatgctgat tttcaagtag ttaatatgag tgaggacatt gaagtggaag 58681 ttccgattca tctgaccgga gaagccattg gagtgaaaaa cggaggcgta ctgcagcagc 58741 cgttatatgc acttactgta aaggccaagc caaaagccat tccgcaaacg attgaggctg 58801 atatttcaag cctcgatgta aatgaagtac tgacgattgc ggatttgcct gctggcggtg 58861 actactcctt taatcatgaa tcagatgagg ttgtggcttc aatccttcct ccgcagcagc 58921 aggaagcagc tgaggtcgat gaagaggaat ctgccgatgc tcagcctgaa ggtgaaaacg 58981 aacaataata gcttaaggcg taaccctccc gcggttacgt cttttgtgct agaatgagaa 59041 gaattatagc ccgtttatga agacgggagt tatgtgacta agggaggatt cgccatgctt 59101 gtgattgccg gtctcggaaa cccggggaag aactatgaaa atacacggca taatgtcgga 59161 tttatggtga tagatcagct tgcaaaggaa tggaatatag agctgaatca aaataaattt 59221 aacggattat acggaaccgg atttgtttcc ggcaaaaagg ttctacttgt taaaccgctt 59281 acatatatga atttatcagg agaatgtttg cggcctttaa tggactacta tgatgtcgat 59341 aacgaagatt tgacagtcat ttacgacgac cttgaccttc cgactggcaa gatccgttta 59401 agaacgaaag gaagcgccgg agggcacaat ggcatcaaat cactgatcca gcatcttgga 59461 acgtccgagt ttgaccgtat ccgcatcgga atcggccggc ctgtaaacgg catgaaggtc 59521 gttgattatg tgttaggctc ctttaccaag gaggaggcac ctgagatcga agaagcggtt 59581 gataaatctg tgaaggcttg tgaggcttct ttgagtaaac cgtttttaga agtcatgaac 59641 gaatttaacg caaaggtata aaatgtaaca acaaagtcca tactacacca aaatgacttt 59701 ttcatcagga ggacccttgt atggctttgc attattattg tcgtcattgc ggagtgaaag 59761 taggcagtct cgaatcttca atggtatcga cagactcact tggatttcag cacttaacaa 59821 atgaggaaag aaacgatatg atttcttata aagaaaatgg agatgtccat gttttgacga 59881 tatgtgaaga ctgccaagag gcgcttgacc gaaatccgca ttaccacgaa tatcacacat 59941 ttattcaata aaaagctttg gtgtagacac tagaccaaag cgtttttctg ttctcgcagg 60001 aaacagagag gaggggccat atggacaaca ttcaaacctt tataaaagaa agcgatgact 60061 ttaaatccat catcaacggt ttacacgagg gcctgaagga acagctgctc gcgggtctgt 60121 cgggttccgc gcgttctgtt tttacttctg ctctggctaa tgaaacgaat aagcctatct 60181 ttctcatcac ccataactta tatcaagccc agaaagtaac agatgatctg acttcacttc 60241 tagaggatcg gtctgtcctt ttgtaccccg tcaatgaact catttcatca gaaatcgcag 60301 ttgcaagccc tgaattgcgg gcgcagcgat tagatgtcat taatagacta acgaatggag 60361 aagcgccaat tgtcgttgct ccggtagctg caatcagaag aatgctgccg cctgttgagg 60421 tgtggaaaag cagccagatg ctcattcaag taggccatga tattgaacct gaccagcttg 60481 cctcacggct ggtagaggta gggtatgagc ggtctgatat ggtttctgcg cccggggaat 60541 tcagtattcg cgggggaatc attgacattt atccgctgac ttcagagaat ccggtgagaa 60601 ttgaactttt tgacaccgag gtggattcaa tccgcagctt taattcagat gatcagcggt 60661 caattgagac ccttacctcg atcaatatcg gtcccgcgaa ggaattaatt atcagaccgg 60721 aagaaaaagc gcgggcgatg gagaaaatcg atagtggtct tgccgcgagc ttgaaaaaat 60781 taaaggctga caaacaaaaa gaaatacttc atgcgaatat ttctcacgat aaagaacgct 60841 tgtctgaagg ccagacagat caggagctcg tgaagtatct ctcatatttc tatgaaaagc 60901 ctgctagttt actagattat acacctgata atacacttct gattttggat gaagtcagtc 60961 ggattcatga gatggaagaa cagcttcaaa aagaagaagc ggagtttata acaaatcttc 61021 ttgaggaagg gaagattttg catgacattc gtttgtcatt cagcttccaa aaaatagtgg 61081 ctgagcaaaa acggcctctg ctgtactact ctttattttt gcggcatgta caccatacga 61141 gcccgcaaaa tatcgtcaat gtgtcaggcc ggcaaatgca gagtttccat ggccaaatga 61201 acgtgcttgc gggcgaaatg gagcgtttta aaaaatcaaa tttcactgtt gtgttcttag 61261 gagcaaacaa ggaacgtacg cagaaattgt catctgtttt ggctgattat gatatcgagg 61321 ccgccatgac agacagcaaa aaagcgcttg ttcagggaca ggtctatatc atggaaggcg 61381 agctccaatc gggatttgag ctgccgttaa tgaagcttgc cgttatcacg gaagaagaac 61441 tgttcaaaaa ccgtgtaaag aagaagccgc gaaaacagaa gcttaccaat gcagagcgca 61501 tcaaaagcta ttctgagctt caaattggag attatgtcgt tcatattaat cacgggatcg 61561 gaaaatacct ggggattgaa actcttgaaa tcaacggcat tcataaagac tatttaaata 61621 tacattatca gggcagtgac aagctttacg tccctgtaga acaaattgat caggtccaaa 61681 aatatgttgg ctccgaagga aaagagccaa agctgtataa attaggcgga agtgaatgga 61741 agcgggtcaa gaaaaaagta gagacatccg ttcaggatat tgctgatgac ttaattaagc 61801 tgtatgccga aagagaagcg agcaagggct atgcgttttc tcctgaccat gagatgcagc 61861 gtgaattcga atcggctttc ccttatcaag agactgagga tcagctccgt tctattcacg 61921 aaatcaaaaa agacatggaa agagaacgtc cgatggaccg cttgctgtgc ggagatgtgg 61981 gctacggtaa aacagaggtt gccatacgtg ccgcgtttaa ggcgatcggt gacggaaagc 62041 aggtagctct gctcgttccg acaaccattt tggcacagca gcactatgaa accataaaag 62101 agcgcttcca ggactatccg attaatatcg gccttctcag caggttcaga acgagaaaag 62161 aagcaaacga aacaatcaaa gggctgaaaa atggaacggt tgatatcgtc atcgggacgc 62221 atcggctgct atcaaaggat gtcgtgtata aagacttagg gctcctcatc attgatgaag 62281 agcagcgttt cggtgtaacc cataaagaaa agatcaagca aataaaagcc aatgttgatg 62341 tattaacgtt aacagcaacg ccgattccgc gtacgctgca tatgtctatg cttggcgtaa 62401 gggacctttc agtcatcgag actccgccgg aaaatcgctt ccccgtacag acgtatgttg 62461 tggaatataa cggcgctctt gtcagagagg cgattgaacg tgagcttgca cgcggaggcc 62521 aggtctattt cttgtacaac cgggtagagg acattgagcg gaaagcggat gaaatttcaa 62581 tgctagtccc tgacgcgaag gtagcatatg cgcatgggaa aatgacagaa aatgaattag 62641 aaaccgttat gctaagcttc cttgaaggag aatcagacgt tctcgtcagc acaaccatta 62701 tcgaaactgg cgtggacatc ccaaacgtca atacgctgat cgtatttgac gccgacaaga 62761 tgggactttc tcagctttac cagctgcggg ggcgtgtcgg ccgttctaac cgtgtggcgt 62821 atgcgtactt cacgtatcgc cgggataaag tgctgacaga agtggctgaa aaaaggctgc 62881 aggctattaa agaattcaca gagttaggtt ccggttttaa aatcgcaatg cgtgacttaa 62941 cgattcgcgg agccgggaat cttcttggtg cccagcagca tggcttcatc gattcggtcg 63001 gatttgacct ctattcacaa atgctgaagg aggccattga ggagcgtaaa ggagacacag 63061 cgaagacaga gcagtttgaa acagaaattg atgtcgagct tgatgcgtat attccggaaa 63121 cttatattca agacggcaaa cagaaaattg atatgtataa acgcttcagg tctgtggcga 63181 caatcgaaga gaagaatgag cttcaagatg aaatgatcga ccgctttgga aactatccaa 63241 aagaagtcga atacttgttt actgttgcag aaatgaaagt ctatgcgaga caggaacgtg 63301 tcgagctgat taagcaggat aaagatgctg tcagattgac gatttctgaa gaagcaagtg 63361 ctgaaattga cgggcagaag ctgtttgagc ttggcaatca atatggcaga caaatcggac 63421 tgggaatgga agggaaaaaa ctcaaaatct ccatacagac gaaaggccgt agtgctgatg 63481 aatggctcga caccgtgctg ggcatgctga agggcttaaa agatgtgaaa aagcaaacca 63541 tttcatcaac gtaaattttg ttactctctg gtgtatatta catttgatgt gacggatact 63601 aatttcaagc gaggcggaag gtacataaag taactgcttt aggtctttcc cacatgtata 63661 taccatcaaa tgaaagagag gcaccagaga tgaaagcaac cggtatcgta cgtcgtattg 63721 atgacttagg tcgggtcgtg attcctaaag aaattcgaag aactctgaga atcagggaag 63781 gcgatccgct tgagattttt gtagatcgtg acggagaagt gattttgaaa aagtactctc 63841 cgatcagtga gcttggagac tttgcaaagg agtatgcaga cgcgctttac gacagcctcg 63901 gccattcagt gctgatttgt gatcgtgatg tatatattgc cgtgtccggc agctccaaaa 63961 aagattactt aaacaagtca atcagcgaaa tgctggaaag aacaatggat cagcgcagct 64021 ccgtgcttga gagtgatgcg aaatcagtac agcttgtgaa tggaattgat gaggacatga 64081 attcttatac tgtaggccca attgtggcga acggtgatcc gataggtgct gtggtgatct 64141 tttcaaaaga tcagacaatg ggcgaagtag agcataaagc cgttgaaaca gcagctggat 64201 ttttggctcg tcaaatggaa cagtaggtct tattcctttc ttcgaaaata ggtatgtaaa 64261 gaacagctct ccttgggacg ctgttctttt tcatgcgtgc cgaaaaagga atccaagggt 64321 tgggatgtgg tataataacc tcgtttttat ttgtgccgcg gtaatacgtg aaccgtattg 64381 cccctgacgt tgggaaggag cttttggatg gacgattcaa taggcgttaa acggcattgg 64441 atttggcagg gggcttttgt tttaattctg gcaggcgtca tcacaaaaat tttaagcgct 64501 gtttacagag tcccgtttca aaacattgtc ggcgatgttg gattttatat atatcagcag 64561 gtatacccct ttcttggtat tgcggtcatg ctgtccacat caggatttcc agtcattatt 64621 tcaaagctga tgaatgatta tagtgaaaaa aatcatcaca ccatattaaa aatatcagcg 64681 ttgtttttgt ctttaatcgg tattttatta tttctttgtt tatatctggg tgctgttcct 64741 attgcactct ttatgggaga ttcgcatcta gccgtgttaa ttcaagtggc cgcatacgcg 64801 tttctgcttt tcccatttgt cgcgttgcta agaggcggtt ttcaggggcg gcacgaaatg 64861 ctcccttcag ccttatcaca gatgacagag cagtttctgc gtgttgcggt gctcttgggt 64921 ttatcatttt ggctcgtgaa aaagggagcc tcgctttata ctgcgggagc ggcagccgct 64981 tcaggctctc ttgccggaag tttggttgca ttgataatac tggggttttt ttggttcaaa 65041 acgaaaagag acaaccaaac ggataggcaa aacgaaaatg tcatcacaac aaaagaattg 65101 acgaaaaaac tgcttttata ttcggtcaca atttgtgtaa gcagtttgct gcttttgttt 65161 atccagcttg ttgatgcttt gaatttatat gcattgcttt cgggtggtga ggcaagcgaa 65221 gaagcaaaat gcctaaaggg gatctatgat cggggacaac ccttgttgca gctcggttca 65281 gtttttgccg taagcattgc gacgtcactc gttccgtata tttctatggc tgtaaaaaac 65341 aaagagctga agatcatgaa agaaaaaatc acgtcatctt tgaaactatg ccttgtgctc 65401 ggtacaggcg catcggctgg gttgatttgc attctaaagc cggtaaatat catgctgttt 65461 caaaatggag aagggacagg tgcgttacaa gtatttagct gctccatttt gtttgcatcc 65521 ttggcggtaa cggcagcggc agtcttacag ggagcgggat acacagtttt tcctgcgata 65581 gcggtgggcg cgggtgttgc ggtgaaatgg gtgttaaaca cacttttggt tccgcgctat 65641 gggattgaag gcgcatcgct tgcgacagcg gcttcctttg cggctgtcgc cggccttaac 65701 ttgtatcagc ttcggcaaaa ggaatggctc gataagctta gaggcgtttt gattccgatt 65761 attggatctg ctcttttgat gtcagctgtt ttgcttgcgt atacgcgtct ctggactttc 65821 ttgtttcctg caacaggaag aggagcggct gtgattgaga gtctttctgc tgttgccatt 65881 ggtggcgcgg tgtttattta ttgtatgatg agattgggaa tatttacaga tgaagagctg 65941 aacagtgtgc cattcggcag caagttaagc aaattcatga gaaggagaga acaaaatggc 66001 gggtaaaatt acagtcgtcg gacttggtgc cggagacatg gaccaattga caattggtat 66061 acacaagctg ctgacgaagg cagatacgct gtatgtcaga accaaggatc atcctttaat 66121 tgaggagctt gaaaaagaaa cgaagaacat ccgtttcttt gatgatatat atgagaaaca 66181 tgatcagttc gaggcggtat atgaagaaat tgcagatatc ctctttgaag cggcgcggcg 66241 tgaggacgtg gtttacgctg tgccgggaca cccttttgtc gcagaaaaaa cagttcagct 66301 gctgacggag cggcaggaaa aggaaaacgt tcaagtgaaa gtcgcggggg gacaaagttt 66361 ccttgatgcc acattcaatg tcttgcaaat tgacccgatt gaaggttttc aatttgtgga 66421 tgccggcaca ttgtccgcgg atgagcttga gctcagacat catctgatca tatgtcaggt 66481 ttacgaccaa atgacggctt ctgaagtcaa gctgacattg atggagaagc tgcctgatga 66541 ttatgaggtc gtcattgtga ctgcagcagg cagccgtggc gaggagatca ggacagtgcc 66601 attatttgag ctggaccgca atgtcgcttt gaacaactta acaagtgtgt atattccgcc 66661 gattaaagaa gagaagctgc tttatcacga attctccacg ttccgaagca tcatcagaga 66721 gcttcgcgga cctaatggat gtccgtggga taaaaagcag acgcatcagt cattaaagca 66781 gtacatgatt gaagaatgtt atgagcttct cgaagctatt gacgaagaag acacagacca 66841 tatgatcgaa gagcttggcg acgttttgct tcaggtcttg cttcacgcgc aaattggtga 66901 agatgaaggt tatttcacaa ttgatgatgt cataaaagga atcagtgaaa aaatggtccg 66961 aagacatccc catgtgttta aagatgttaa ggttcaggat gaaaacgatg ttttagccaa 67021 ttgggaagat ataaaaaagg ccgaaaaaaa tacatctgaa tcatcattac tagacagcgt 67081 accgaaaacc cttccagctc tttcgaaagc agctaaattg cagaaaaaag cagcgaaggt 67141 cggttttgac tgggaagacg tcagcgatat ttgggaaaag gtaagtgagg aaatgaagga 67201 attttcttct gaggtttctg aagctcctca cgaacacaat cttaaagctg agtttggcga 67261 cattttgttc gcgctggtga atgtagcccg cttctacaaa atagagccag aggaagcgct 67321 gaccatgact aatgacaaat tccggagacg gttctcgtac attgaggaaa cagcgaagga 67381 agagggagtc gagttggctg atatgtccct tgaggacatg gacaaactgt ggaatgaagc 67441 aaaagaaact gagaggagat catagatatg agattagata aatttttgaa agtatcacgg 67501 ctgatcaaac ggcgtacact agcgaaggaa gtagctgacc aaggacgaat ctctattaac 67561 ggaaaccaag ctaaagctag ctctgacgta aaaccgggag atgaactaac ggtccgcttc 67621 ggccaaaagc ttgtaacggt tcaagttaat gaattgaaag acacgacgaa aaaagaagaa 67681 gctgcaaaca tgtacacgat tctaaaagaa gaaaaactcg gcgaataggc ttgttctaaa 67741 aaaacccccc acctcataca atgcagtaat aatgctaaaa gtatcgagga tatgggggct 67801 gaatagatga attcatatta tgatcaaaaa ggttcttcgt ctgttccgga acagcatgat 67861 gtgacaatga aaggccggaa gcatttagat atttctgggg ttaagcatgt ggagagtttt 67921 gataacgaag aattcctgct ggaaacggtg atgggaatgc tctccgtcag aggccaaaac 67981 ctgcagatga aaaatcttga tgtggaaaaa gggattgttt cgattaaagg cagggtattt 68041 gatttagtgt acttagacga acaacaaggg gataaagcta aagggttttt tagcaagttg 68101 tttaaatgac gctgacgaca caattctata caatgctagc gatgtccggt atgggtctct 68161 ggcttggtgc ttcgcttgat acataccggc tctttgtcat tcgtgccaaa acagccagat 68221 ggctattatt tattcatgat attcttttct ggattatgca agggctgctt ttcttttatg 68281 tcttgcttca tgtaaatgag ggagaattca ggatttacat ctttttagcg gttctgctgg 68341 gcgttgcgac gtatcagagc ctttgcaaac gaatctatat aaaaatactg aaattcgtca 68401 tttaccttgt tgtttctgtt tatcaattct tcaaaaaact cattcagcac gtgttatttc 68461 gtcctattgt gtggacatgc ggagcgatca tctggctggc ggcattttta ttcaagaaaa 68521 catacagcct gataggtttt ctcctgctgt gtctatataa aatagtcatg gttctgtgtt 68581 ttccgatccg ttttatcgcg aaacaatgtt tgaaacttct tcctgtgaaa atgcgtctaa 68641 cttttagacg ttattttgaa aaaggtgcag gatttctcaa aaagaagaag aaactattga 68701 taaccataag aacgaccatc acacggtttt tgaagagatg aaaggaggac cgtctggttt 68761 gaatttttcc agggaacgaa cgataactga aatacaaaac gactataaag aacaagtaga 68821 acggcaaaat cagctgaaga aacgaagacg caaagggctg tacagacggt taactgtatt 68881 cggcgcccta gtattcctga cggcaattgt gctggcaagc tctgtatggt cccaaacatc 68941 ttcccttagt gcaaaagaag aaaagaaaga acagcttgaa aaagaactga aaagtttaaa 69001 gacaaaacaa acggatttaa aagaagaaat atccaaattg aaggatgagg attacgtcac 69061 agagcttgcc agaagggact tattcatgtc tggagacgga gaaattatct tcaatgtgga 69121 gaagaagagc aagtagcctt gttgacactt aaatttttat ttaggtataa ttaagcaaac 69181 gatcttttta taagcctaag gaggagcact ttttttatgt cgattgaagt tggcagcaag 69241 ttgcaaggga aaattacagg tattacaaat tttggagcat ttgttgaatt gcctggaggc 69301 tcaaccggtc tcgttcacat tagtgaggta gctgataatt atgtcaaaga cattaacgac 69361 cacttaaaag tcggcgacca agttgaagtg aaagtcatca acgttgaaaa agacgggaaa 69421 attggtttat ctattaaaaa agctaaagac cgtccgcaag ccagacctag aaatgatttc 69481 cgtccgaaag aatcttttga acagaaaatg aataagtttt taaaagacag cgaagatcgc 69541 ttgtcatctt taaaacgcaa tacggaatca aaacgtggag ggcgcggagc aagaagagga 69601 taacttgctg ctttctataa aataaatgaa gcatccgttc atcccgacgg atgctttttt 69661 attatcctca ttctctttaa gagtcagaaa attacaacat taaagtttct gttgacgaaa 69721 gagacaaacc tttgtattat ataacttgtg cttagaagca caaaacaata tggcggtgta 69781 gctcagctgg ctagagcgta cggttcatac ccgtgaggtc gggggttcga tcccctccgc 69841 cgctaccata tttgtttggc ccgttggtca agcggttaag acaccgccct ttcacggcgg 69901 taacacgggt tcgaatcccg tacgggtcat cctaacaaat cggtttctct tgcagaagcc 69961 gatttttttc atttttagac aacattccgg aaattctttt cataaacgaa tatcaaggca 70021 gaaaccgtcg aagatttctt tggtattgtt accttctttt gacaaaatcc tatctgtgct 70081 ttcgctataa tgacaggcaa cgaatataac aggtgggaga tgagaggaat ggaaaaagca 70141 gaaagaagag tgaacgggcc aatggcggga caagctttgg aaaaactcca atcgtttttt 70201 aacaggggca cgaagctggt gactcatcat ttgcattcac tgtttttcta taaaggattc 70261 atttatgttg tcatcggatt tttgcttgga cgggctttca tattatccga ggtgcttcct 70321 ttcgcacttc ctttctttgg agcgatgctt cttatcagaa gagacaaagc gttttatgcg 70381 gttttggctg tgcttgcagg tgcgctgacc atatctccaa agcactcatt gctcatactg 70441 gcggcattgc tggcattctt cgtattttct aaagtggctg ccttcattac cgacgatcgt 70501 gttaaagcgc tcccgattgt cgtgttcttc tccatggctg cagcaagagc cgggtttgtt 70561 tatgcccaaa atggcgtatt tacaacctat gattatgtaa tggctatcgt tgaggctgga 70621 ctatcgttta tcttaacact gattttcctt cagagccttc cgatttttac tgtgaaaaaa 70681 gtgaaacaat cattaaaaat agaggaaatc atttgcttta tgattcttat tgcctctgtt 70741 ttaacggggc tggctggctt gtcctaccaa gggatgcagg cagaacatat attggctcgt 70801 tatgttgtgt tgagtttttc ctttattggc ggagcaagca tcggctgtac ggttggggtt 70861 gtgaccggcc tgattcttgg cttggcgaat atcggaaacc tatatcaaat gagtctgctt 70921 gctttttccg gtttattggg cggtttgctg aaggaaggga aaaaagcggg tgcagcaatt 70981 ggtttgatcg ttggatcact tcttatatct ttatatggtg aaggctctgc cggtctgatg 71041 acaacgctct atgagtcatt aatcgcagtc tgcctgtttt tgctcacacc tcaatctatt 71101 acgaggaaag tggcgagata tattccggga actgtcgagc atcttcaaga gcaacagcaa 71161 tacgctagaa aaatccgtga tgtcactgct cagaaggtag accaattctc caatgtattt 71221 cacgcgctgt ctgaaagctt tgcaaccttt tatcaagcat cagacgaaca gacagatgac 71281 agcgaagttg atctgttctt aagcaaaatc acggagcatt cctgccagac gtgctacaag 71341 aaaaacaggt gctgggtaca gaactttgat aaaacatatg acttaatgaa acaagttatg 71401 cttgaaacag aggaaaaaga atatgcatca aaccgaaggc tgaaaaaaga gtttcaacag 71461 tattgttcta aatccaagca ggttgaagag ctgattgagg atgagctcgc acatcatcat 71521 gcccatttga cactcaagaa aaaagtccaa gacagcaggc gccttgttgc tgaacagctt 71581 ttaggcgttt ctgaggttat ggccgacttt tctcgggaaa taaaaagaga gcgagaacaa 71641 cactttctgc aggaagagca aatcatagaa gcgcttcagc atttcggaat tgagattcag 71701 catgtcgaga tctatagtct tgaacaagga aatatcgata ttgaaatgac cattccgttc 71761 agcggacatg gagaaagtga aaaaatcatt gctcctatgc tttctgacat tctggaggaa 71821 caaattcttg tgaaagccga acagcactct ccgcatccga atggatacag ccatgtcgcc 71881 tttggatcaa caaaatcata cagggtgtcc acgggagctg ctcacgctgc gaagggcggc 71941 ggccttgtct ccggtgacag ctacagcatg atggagcttg gagccagaaa atatgctgca 72001 gcaatcagtg acggaatggg caatggcgca agagcgcact ttgaaagcaa tgaaacgatc 72061 aagcttcttg aaaaaatcct tgaatcgggc attgatgaaa aaatagcaat taaaacgatc 72121 aacagcatac tgtctctaag gacaactgac gaaatatatt ccacgcttga cctatctatt 72181 atcgatcttc aagatgccag ctgtaaattt ttgaaggttg gatcgacgcc cagctttatc 72241 aaacggggtg accaggtcat gaaagttcaa gcgagcaatc tgccaatcgg tattattaat 72301 gaattcgatg tggaggttgt gagtgaacag ctgaaagcgg gtgacctctt aattatgatg 72361 agtgatggca tttttgaggg gcctaagcat gtggaaaatc acgacttatg gatgaagcgt 72421 aaaatgaaag ggttgaaaac aaatgacccg caggagattg ccgatttgct tatggaagaa 72481 gtcatccgca caagatccgg ccaaattgag gacgatatga ctgttgttgt cgtccggatt 72541 gatcacaata caccgaagtg ggcatccatt cctgttccgg caatctttca aaacaaacaa 72601 gaaatttcat aacgcttccg tataaatcaa atttcttctg gcgaagatgg gaatatatga 72661 atctgagaat cctcgtattc tccaggagga atgaatgtga acaacggaca tttaaatcaa 72721 attttgctga taacggatgg ctgctcaaac catggggaag acccgcttgc aatggctgct 72781 tttgctaaag agcaggggat tacggtaaat gtcattggta taatggaaga aaatcaaatt 72841 gaccctgagg caatgaagga agtcgaaggg attgcacttg ccggaggagg cgtgcaccaa 72901 gtcgtttatg catctcagct ttcacaaact gttcaaatgg taacaaagaa agcgatgacg 72961 caaaccttac aaggtgtagt caatcaagaa ctgaaacaga ttctcggaaa gaatgtggaa 73021 atggaagagc tttctccgga aaaacgcggc gaagtcatgg aagtggtaga cgagcttgga 73081 gaaacggtgc atcttcaggt tttggttctt gttgatacaa gtgcaagtat ggcgccaaag 73141 cttccaacag taaaagaggc gctgattgat ttgtctgtaa gcctcaattc ccgaattggg 73201 aataacgaat ttgcgatgtg tatatttccc gggaaaaaac aagaggtcga gcttgtgctg 73261 aactggacac cgaagctgca atctctttcc acactctttg caaagctttc gacaggcggc 73321 atcacgccga caggtccggc gattcgtgaa gcgacactgc agtttgaaaa aatacgctca 73381 agaaggggca tgctggcaga tgatgaacga cgctttgacg agtttggcat gtagcctcaa 73441 gccgggtacg acaatcaaag gcaagtggaa tggaaacact tatacattgc gtaaacagct 73501 tggtaaaggg gccaatggaa ttgtgtattt ggcagaaaca tcagatggac atgttgcctt 73561 aaaggtgagt gatgacagcc tgtctattac ttctgaagtg aatgtcttga aatctttctc 73621 aaaggcccag tccgttacga tggggccttc tttttttgat acggatgatg cctatattcc 73681 cagtgccaat acgaaagttt cattttatgc aatggaatac ataaaagggc cgctgctttt 73741 gaagtatgtc agtgataaag gagcagagtg gataccggta ttaatgattc agctgttatc 73801 cagcttatcg gtgcttcacc agcaaggatg gatattcggc gatcttaaac ctgataatct 73861 gatcgtaact ggtccgcccg caaggatccg ctgcattgat gtgggcggca cgacaaagga 73921 aggccgggcg ataaaagagt atacggagtt ttatgacaga ggctattggg ggtatggaac 73981 aagaaaggca gagccatcct atgatctgtt cgcagttgcc atgattatga tcaacagtgt 74041 gcataaaaaa gaatttaaga aaacgaacca gcccaaagaa cagcttaggt ctctcatcga 74101 aggaaacccg ctgcttcaaa agtataaaaa agcgcttttt tcagccttga acggagatta 74161 tcaatccgca gatgaaatga aaaaggatat gctagacgcg gggcaaaaag cagcacaaag 74221 aaaacagcct ataaaagcat caccgcagcc tgccacacga caaagacagc aaaaaccgcg 74281 ccaaggaaaa ataacgaaga cgcgatatac cccaaaacag aaaccggcta agtcgggggg 74341 gttatttgaa acaacgctta tcgtgatcag tgttttagcg ctttatttcg cctatattat 74401 ctttttctta atctgaatgg tgcaaactgc agagcctatg cttcttcttt gcttggaggg 74461 gttgaaagtg ttaggatatg aatatcttta aaatacctgc tcattgtgag gaggacattg 74521 tgaaaagtgt caaagatttt ttaaacaaac acaatcttac gttaaaaggg gcgacaatca 74581 ttgtaggcgt ttccggcggt ccggactcaa tggctcttct tcacgcgttg catacgttat 74641 gcggccgttc agcgaatgtt attgcagctc acgttgacca tcggttcaga ggtgcggaat 74701 ccgaggagga catgcgtttt gtccaagctt attgtaaagc tgaacagctc gtgtgcgaaa 74761 cggctcaaat caatgtaacc gcatatgcac aggaaaaagg actcaataag caggctgcag 74821 cacgcgattg ccgctaccag ttttttgagg aaatcatgtc gaagcaccaa gcggactatc 74881 tggctcttgc gcatcatggt gatgaccagg ttgaaacaat gcttatgaaa ctggctaagg 74941 gtacgcttgg aacgggactt gcgggaatgc agccggttag acgttttggg acagggcgga 75001 tcatcaggcc gttcttaacc attacaaagg aagagatcct tcactattgc catgaaaacg 75061 gcttgagcta ccggacggat gaaagcaacg ccaaagatga ctacacaaga aacagattca 75121 gaaaaacagt gctcccgttt ttgaagcagg aatctccgga tgtgcataaa aggtttcaga 75181 aagtgagtga agcactgacg gaagatgagc aattcttaca gtcattaacg aaagatgaaa 75241 tgaataaagt aatcacaagc cagtctaata catcagttga aatcaattcc tctcaattgc 75301 ttgccctccc gatgccttta caaagaagag gagttcaact aatattaaac tatctttatg 75361 aaaacgttcc atcatccttt tcagcccatc acattcagca gtttctcgat tgggcggaaa 75421 atggcggtcc ttcaggagta ctggactttc cgaaagggct gaaggtggtc aaatcatatc 75481 agacatgttt gtttacattt gaacaatggc agtgcaaaaa tgttcccttt gaataccaaa 75541 ttagcggagc tgctgatgaa acggcagtgc tccctaatgg atatctgata gaggcaaggc 75601 attatgcgga ctcgcctgaa gaacatggga atgctgtttt tatcacaagt gaaaaaaagg 75661 tgcgatttcc cttaacaatc cggacgagaa aagctggaga ccggatcaaa ctaaaaggga 75721 tgaacggctc aaaaaaggta aaggatatat ttattgataa gaaattgcct ctccaagaaa 75781 gagacaactg gccgattgtg acggacgcaa gcggtgaaat tatctggata cctggcttga 75841 aaaaatcaat ttttgaagat cttgtgattc caaacagcga ccgcattgta ttacaatata 75901 gacagcatga aaagtgtagg gggcaagcaa aatcatgatg aaacatgata tcgagaaagt 75961 actgatctca gaggaagaga tacaaaagaa agtaaaagag ttaggtgcag aattaacgag 76021 cgagtatcaa gatacatttc cgttggcaat cggtgtgtta aaaggagcac ttccttttat 76081 ggcggatctt atcaagcata ttgatacata tttggaaatg gatttcatgg atgtatcaag 76141 ctacggaaat tctacggttt cttctggaga agtaaaaatc attaaagatt tggatacatc 76201 tgtagagggc cgggacatct taattattga agatatcatc gacagtgggt taaccttaag 76261 ttatctcgta gagctcttcc gataccgtaa agcaaaatca attaagattg ttaccctttt 76321 ggataaaccg agcggaagaa aagcggacat caaagcagac tttgtcggtt ttgaagttcc 76381 tgacgcgttt gtagtgggtt acggacttga ttatgctgag cgctatcgca atctgcctta 76441 tatcggagtg ttaaaaccgg cagtttatga aagctgatcg gcagcctgct tccgagatgg 76501 ttattgtttg tattggaatg attttctatg gtactattga acatagttgt gcttactgtg 76561 ggaggaggta aggaatgaat cgggtcttcc gtaataccat tttttattta cttattttat 76621 tagtagtaat cggggttgtg agctacttcc agacctcaaa tccgaaaaca gaaaatatgt 76681 cgtacagtac gttcatcaaa aacctggatg acgggaaagt tgatagcgta tcggttcagc 76741 ctgtcagagg tgtttatgag gtaaaagggc agctgaaaaa ctacgacaaa gatcaatact 76801 ttttgactca tgttcctgaa ggaaagggag cagaccagat atttaacgct ttgaaaaaga 76861 cagacgtaaa ggttgagccc gcgcaagaaa caagcggatg ggtgacgttc ctgacgacca 76921 tcatcccatt tgtcattatc tttattctgt ttttcttcct gctcaatcag gctcaaggcg 76981 gcggcagccg tgtcatgaac tttggcaaga gtaaagcgaa gctgtataca gaggaaaaga 77041 aacgcgtcaa atttaaagac gttgcagggg ctgacgaaga aaagcaagaa cttgttgaag 77101 ttgttgagtt tctgaaagat ccccgcaagt ttgccgagct cggcgccaga ataccgaaag 77161 gcgtgctttt agtcggacct ccgggtaccg gtaaaacatt gcttgccaag gcttgtgcag 77221 gagaagccgg cgtacctttc ttcagcatca gcggatctga tttcgttgaa atgtttgtag 77281 gggtcggtgc ttcccgtgtg cgtgacttgt ttgaaaatgc gaaaaagaat gcgccttgtt 77341 tgatcttcat tgatgaaatt gacgcagtcg gacgccagcg tggcgctggt ctcggcggtg 77401 gacacgatga acgtgaacag acgctaaacc aattgcttgt tgaaatggac ggattcagcg 77461 ctaatgaagg aattatcatc attgctgcga cgaaccgtgc ggacatcttg gacccagcct 77521 tacttcgtcc gggacgtttt gaccgtcaaa tcacagtgga ccgcccagat gtcattggcc 77581 gtgaagctgt attgaaagtc catgcgagaa acaaaccgct ggatgaaacg gttaacctaa 77641 aatcaattgc catgagaaca ccaggcttct caggcgctga cttagaaaac ctcttgaatg 77701 aagctgcgct tgtagcggct cgtcaaaaca agaaaaaaat cgatgcgcgt gatattgacg 77761 aagcgacgga ccgtgtaatt gccggacccg ctaagaagag ccgcgttatc tccaagaaag 77821 aacgcaatat cgtggcttat cacgaaggcg gacacaccgt tatcggtctc gttttagatg 77881 aggcagatat ggttcataaa gtaacgattg ttcctcgggg ccaggctggc ggttatgctg 77941 ttatgctgcc aagagaagac cgttatttcc aaacaaagcc ggagctgctt gataaaattg 78001 tcggcctctt gggcggacgt gttgctgaag agattatctt cggtgaagtc agcacagggg 78061 cgcacaatga cttccagcgt gcgacgaata ttgcaagacg aatggttaca gaattcggta 78121 tgtcagaaaa actgggaccg ttgcaatttg gacagtctca gggcggtcag gtattcttag 78181 gccgtgattt caacaacgaa cagaactaca gtgatcaaat cgcttacgaa attgatcagg 78241 aaattcagcg catcatcaaa gaatgttatg agcgtgcgaa acaaatcctg actgaaaatc 78301 gtgacaagct tgaattgatt gcccaaacgc ttctgaaagt tgaaacgctt gacgctgaac 78361 aaatcaaaca ccttatcgat catggaacat tacctgagcg taatttctca gatgatgaaa 78421 agaacgatga tgtgaaagta aacattctga caaaaacaga agaaaagaaa gacgatacga 78481 aagagtaatt cgctttcttt ctaaaaaaac tgccggctga cgctggcagt ttttttatgt 78541 aaatgattgg ctcagctgcg gcttttacaa tcatccaatt ctggtatcga tttgtttaca 78601 aatgagccgc tgatcgtgta tggtattgta gaatgtttgt aaaaagtaaa gtagagaaac 78661 tattcaaaag tggtgataga ggttgttact ggttatcgat gtggggaaca ccaatactgt 78721 acttggtgta tatcatgatg gaaaattaga atatcactgg cgtatagaaa caagcaggca 78781 taaaacagaa gatgagtttg ggatgatttt gcgctcctta tttgatcact ccgggcttat 78841 gtttgaacag atagatggca ttattatttc gtcagtagtg ccgccaatca tgtttgcgtt 78901 agaaagaatg tgcacaaaat actttcatat cgagcctcaa attgttggtc caggtatgaa 78961 aaccggttta aatataaaat atgacaatcc gaaagaagta ggggcagaca gaatcgtaaa 79021 tgctgtcgct gcgatacact tgtacggcaa tccattaatt gttgtcgatt tcggaaccgc 79081 cacaacgtac tgctatattg atgaaaacaa acaatacatg ggcggggcga ttgcccctgg 79141 gattacaatt tcgacagagg cgctttactc gcgtgcagca aagcttcctc gtatcgaaat 79201 cacccggccc gacaatatta tcggaaaaaa cactgttagc gcgatgcaat ctggaatttt 79261 atttggctat gtcggccaag tggaaggaat cgttaagcga atgaaatggc aggcaaaaca 79321 ggaaccaaag gtcattgcga caggaggcct ggcgccgctc attgcgaacg aatcagattg 79381 tatagacatc gttgatccat tcttaaccct aaaagggctg gaattgattt atgaaagaaa 79441 ccgcgtagga agtgtatagg aggtttagta atggattatt tagtaaaagc acttgcgtat 79501 gacggaaaag ttcgggctta tgcagcgaga acgactgata tggtaaatga ggggcagaga 79561 cgccatggta cgtggccgac agcatccgct gcactaggcc gtacaatgac agcttcactt 79621 atgctcggcg ctatgctgaa gggcgatgat aagctgaccg tgaaaatcga gggcggaggt 79681 ccgatcggag ctattgtagc tgatgccaat gccaaaggag aagtcagagc ctatgtctct 79741 aacccgcaag ttcattttga tttaaatgaa caaggtaagc ttgatgtcag acgtgcggtt 79801 ggaacaaacg gaacgttaag tgtcgtaaaa gatttaggtt tgcgcgagtt cttcacagga 79861 caagtagaaa tcgtttcagg agaattagga gatgatttta cttactatct tgtgtcatct 79921 gagcaggttc cttcatcagt gggcgtaggt gtgctcgtaa atcctgacaa taccattctt 79981 gcggcagggg gctttattat tcagctgatg ccgggaacag atgatgaaac aatcacaaaa 80041 attgaacagc gtctatctca agtagagccg atttctaagc tcatccaaaa agggctgaca 80101 ccagaagaaa ttttagaaga agtcctaggc gagaaacctg agattttgga aacgatgcct 80161 gtcagattcc attgcccttg ttcaaaagaa cggttcgaaa cagccatttt aggactaggc 80221 aaaaaagaaa ttcaagatat gatagaagaa gatggacaag ccgaagcagt atgccatttt 80281 tgtaatgaaa agtacttatt tacaaaagaa gagctggaag ggcttcgtga ccaaactacc 80341 cgctaagctc tttagcgggt ttttaatttg agaaaagggg ctgaaagcag gtttgaaatc 80401 aagaacaatc tggaccatta ttttaggggc gctgttggtt tgctgtattg ctgttgcata 80461 tacgctgacg aaatcccaag ccggcgcatc gtcatccggt gagtctattg cgactatcgg 80521 aggcaagagt gtgacaagag aagaatggct gaaagaaatg gaagatcagt atggtaagtc 80581 aacgcttgaa gatatgatca atgtccgagt tgttgagcag ctggctaaaa agaacaaact 80641 taaaatatcc aaaagcgaag ttgatcgtga gtttttgctg attaaagcgg tcaataattc 80701 cttttacgaa gatgaacata cgacggagaa agagtggaaa gaccaaattc gttataatat 80761 cctccttgag gatttgttaa caagggatat cgatatctca aacaaagaat tggaatcatt 80821 ctataataaa aataaggaac tatatcagtt tgatgattcg tatcgaattc ggcacattgt 80881 tgtaaaagat gaagaagaag caagagaagt cctgaaagaa ctgaaaggcg gatcaagctt 80941 tgaagctgtc gctgccgaaa gatctacaga cagatataca tcaccatacg gcggagattt 81001 aggttttgtc acagaggcat cagacaacat tccatcagca tacattgaag aggcgaaaac 81061 actcaaagag gatgaatggt ctcaggaacc aataaaggtc agcaacggat atgccattat 81121 ccagctgaaa gaaaaactaa aggcaagaac gttctcattt gatgaagtaa aggaccagat 81181 cagacggcaa atcgcaatgg atcagctagg cgataaagcg acagttaaga cactttggaa 81241 agaagccgat gtatcttggt tttatgggga aaaaagtact aagtgattga caaaaaattt 81301 tgaaattgat agattatata cataatacca atacaaatag tcggaaattg aggtgtcgag 81361 aatggtacgt gtagcaaact ccattactga attaattggg aatacgccaa tcgttaaatt 81421 aaatcgcctt gcagatgaaa acagtgcgga tgtatatcta aaacttgaat acatgaaccc 81481 tggaagcagt gtaaaagacc gtatcggttt agctatgatt gaagcggctg aaaaagaagg 81541 aaaattaaaa gccggtaata caatcattga accgacaagc ggaaatactg gaatcgggct 81601 tgcaatggtt gctgctgcta aaggattaaa agccattttg gttatgcctg atacaatgag 81661 catggagcgc cgcaaccttc ttcgcgcata tggtgctgag cttgtgctga ctcctggtgc 81721 ggaaggcatg aaaggtgcta ttaagaaagc tgaagagctt gctgaaaagc acggatactt 81781 tgtgccgcag cagtttaaca acccttctaa ccccgaaatt caccgccaaa caacgggtaa 81841 agaaatcgtt gagcaattcg gtgatgatca gcttgacgca tttgtagccg gaatcggaac 81901 gggcggaacg attacgggag cgggcgaagt gctgaaggaa gcataccctt ccatcaagat 81961 ttatgctgtt gaaccgtcag attccccagt gctttcagga ggaaaaccag gcccccacaa 82021 aattcaggga atcggagcag gattcgtgcc ggacatctta aacactgaag tatatgatga 82081 aatcttccct gtgaagaatg aagaagcatt cgaatatgcc cgcagagctg cacgtgaaga 82141 aggaattctc ggaggcatct catcaggtgc ggcaatttat gctgctcttc aagtagcaaa 82201 aaaactcgga aaaggcaaaa aagtattggc catcattcca agtaacggcg aacgttatct 82261 aagcacgccg ctgtaccaat tcgattaaaa aaagccaaaa ctcccggttc gccgggagtt 82321 tttttatatt tcgtgcatca aatatgccat gtctgcgacg aatgttattc ttggaagaga 82381 aattcacttt tttcactaac aacattgctt tacaattaaa aacaagtaaa aaagaaaata 82441 gaggaatgat acaaatggca caacgcagac cggcaggcaa aaaaatacct tttcaaaaag 82501 actcattctt acaacaattt gagaaacttg cgcaatcccg gaaacatcat gtacttctcg 82561 aaagtgcaag aggcggcaga tatagtatag ccggtcttga tccaattgcg actgtgaaag 82621 gaaaagacgg aataactaca attaagcatg gtgatgagat gctgtttaaa gaaggtgatc 82681 cattacgggc cttccacagc tggtttaaaa cactggaaac agaaacgaat catgagttcc 82741 ctgactttca aggcggggca atcgggtttc tcagctatga ttacgcacgg tacattgaaa 82801 attttaaaat gctctcatta gatgatttag aaacaccaga tatttatttt cttgtttttg 82861 atgatatagc agtttatgac catcaagaag agtctctatg gctgattact catgttaatg 82921 gttctgatca ggaaacagcg gatgtgaagc tatctgagtt agagcagatg tggttgactg 82981 agcttcccgc tgtcacttcg cgagagatga agcctgaaac agctggttct ttcgcggcgc 83041 catttaccga ggatgggttc tcacaagctg tagagaaaat caaacaatac attgccagcg 83101 gagatgtgtt tcaagtcaat ctatcaataa ggcagtcaca gtcactgtct gtccacccat 83161 atcaaattta caaaaccttg agagaagtaa atccttctcc ttatatggcg tatttagaaa 83221 cacctgattt ccaaatcatt tgcggatcgc ctgaactgct tgtcagcaaa aagggcaagc 83281 tattagagac gagaccgatt gcgggcaccc gttccagagg gaaaacaaat gaagaagacg 83341 aggcgcttgc aaacgaattg atacacaatg aaaaagaacg cgcggaacat gtcatgctgg 83401 ttgatcttga gcgaaatgat ctgggaagag tatcacgtta cgggtctgtg cgcgtaaatg 83461 aattcatggc aattgaaaaa tactcgcatg tgatgcacat tgtgtctaat gtccaaggtg 83521 aactgcagga tgggtatgat gctgtagata ttattcatgc tgtgtttccc ggaggaacca 83581 ttactggtgc accgaaagta agaacgatgg aaattataga agaacttgag ccgacacgcc 83641 gagggcttta tactggatct ataggatggt ttggatataa tcacgatctg cagtttaata 83701 tcgtcattcg aaccatttat gcaaccggag ggcaggcatt tatgcagtcc ggtgcaggag 83761 ttgtgattga ttctgttccg aagcacgaat acaaggaatc attcaaaaaa gcttttgcga 83821 tgcaaagagc attagagctg agcgaagaag agacaaaaat tagatgaggt gagcggagaa 83881 atgattttaa tgattgataa ctacgattca ttcacgtaca acttggtaca gtatttgggc 83941 gagcttgggg aagagctggt tgtgaaacgc aatgacagca tcacaatcga tgaaattgaa 84001 gaactgtctc cggactttct gatgatatct cccggaccgt gcagccctga tgaggcggga 84061 atcagcctcg aagcaattaa acatttcgca gggaaaattc ctattttcgg tgtatgtctc 84121 ggacatcagt ccatcgcaca agtgttcggt ggtgatgttg ttagggcaga acggcttatg 84181 cacgggaaaa cctcggatat cgagcatgac ggcaaaacca tttttgaagg gttgaaaaat 84241 ccccttgttg cgacgcgata ccactcgctg atcgtaaaac ctgagacgct gccaagctgt 84301 tttacagtaa cagcacaaac gaaagaagga gaaatcatgg ctattcgcca caatgacctc 84361 ccgatagagg gtgtgcaatt tcacccagag tctattatga cctcctttgg gaaagaaatg 84421 ctcagaaatt ttattgagac atatcgcaag gaagttattg cgtgatgata tatgtgaacg 84481 gccggtatat ggaggagaaa gatgcagttc tttctccttt tgaccatggg tttttatatg 84541 ggatcggtgt tttcgaaacc ttcaggctct acgaaggctg cccgtttttg cttgattggc 84601 atatagagag gcttgaacgc gcgcttaagg atctgcaaat cgaatatact gtttcaaagc 84661 atgagatcct tgagatgctg gacaagctgc ttaagctaaa tgatatcaag gatggcaatg 84721 cccgcgtcag actgaacata tcagcgggaa tcagcgataa aggctttgtc gcccagacgt 84781 acgataagcc caccgtttta tgctttgtga atcagctgaa accagaaagt cttcctttgc 84841 aaaaagaagg aaaggtttta tcgatacgga gaaacactcc agagggatcg ttccggttaa 84901 aatctcatca ttatctaaat aatatgtatg cgaaacggga aattggaaat gatccgcgtg 84961 tcgagggaat tttcttaacg gaggatggag ctgttgcaga gggtatcata tctaatgtct 85021 tctggagaaa aggtcgctgt atctatacgc catcgcttga taccggtatt ctggacggcg 85081 tcacgagacg ttttatcata gaaaatgcaa aggatatcgg cctggagctc aaaacgggcc 85141 gatatgagct agaagctctc ttgacagctg acgaagcgtg gatgacgaac tcggttcttg 85201 aaatcatccc gtttactaaa atagaagaag taaactatgg aagccaaagc ggagaagcaa 85261 cctccgctct tcaattgtta tacaaaaaag aaataaagaa catgattcat gaaaagggag 85321 gaagagcatg gcgcagcaca caatagatca aacacaagta atccacacta agcccagcgc 85381 tttatcatat aaagagaaga cgctggtgat gggaatttta aacgtaacgc ctgactcttt 85441 ctcggacggc ggaaaatatg acagcttgga caaggcgctg ctgcacgcga aagagatgat 85501 cgatgatggt gcccatatca ttgatattgg aggggaatcg acaaggcctg gcgctgagtg 85561 cgtatctgag gatgaggaga tgtccagagt cattccggtg attgagcgga ttacgaaaga 85621 gcttggtgtt cctatttctg tagacacgta caaggcttct gtcgcagatg aagcagtgaa 85681 agccggtgca tccattatca atgatatttg gggagccaaa catgatccga agatggcttc 85741 cgttgcagct gaacataatg ttccaattgt actcatgcat aaccgccctg aaagaaacta 85801 caatgactta ttgccggata tgctgtcgga cttaatggag agtgtaaaaa ttgctgttga 85861 ggccggagta gacgagaaga acattattct tgatcctggt atcggtttcg cgaaaaccta 85921 tcacgataac ttggcagtga tgaacaaact agagattttc agcggattgg gatatccggt 85981 tcttctggca acctcccgaa aaagattcat cggacgtgtt ctggatcttc cgcctgagga 86041 gcgggctgag ggcacaggcg cgactgtgtg tctcggcatt caaaaaggct gtgacattgt 86101 cagggtccat gatgtaaagc aaattgccag aatggcgaaa atgatggacg cgatgctgaa 86161 taagggaggg gtgcaccatg gataaagttt atgtagaagg tatggagttt tacggatatc 86221 acggtgtgtt cacagaagaa aacaaacttg gccagcggtt taaagtcgat ttaaccgctg 86281 agctggattt aagcaaagct ggacagacag acgaccttga gcaaacgatc aactatgctg 86341 agctctatca cgtatgtaaa gatatcgtgg aaggggagcc tgtgaaattg gtggaaacgc 86401 tggcggaacg tattgctggc actgttctcg gaaaatttca gcctgttcag caatgtacgg 86461 tgaaagtgat taagccagac ccgccaattc ccggacacta taaatcagta gcaattgaaa 86521 ttacgagaaa aaagtcatga acaacatagc ttatattgca cttggatcta atattggaga 86581 tagagaaacg tatttaaggc aagcagtggc tttactgcat cagcatgctg cggtgacagt 86641 cactaaagtg tcgtctattt acgaaactga cccggtcgga tacgaagatc aagctcaatt 86701 tttgaatatg gctgttgaaa tcaagacatc attgaaccct tttgaactcc ttgaactgac 86761 gcagcagata gaaaatgaat taggcagaac aagggaagta agatgggggc cgcggacggc 86821 agaccttgac attttgttat ttaatcgtga aaatattgaa acagagcaac taattgttcc 86881 gcatccgaga atgtatgagc gtttgtttgt ccttgcgccg cttgcggaaa tttgccagca 86941 ggttgaaaaa gaggctacaa gcgccgaaac agaccaagaa ggtgtaagag tatggaagca 87001 gaaatctggg gtagacgaat tcgtgcattc agaaagctga aaggttatac tcaagaagga 87061 tttgcaaaag cattaggtat atcagtttct attctcggcg aaattgaacg cggaaaccga 87121 ttgccgtctg ctgccatcat tcaagatgca gcagatgttt taaatataag tgcggacgaa 87181 ttggcgccgc cagaaaaata gaacaaatga aaggaggaga aaaattgttc aaaatcggag 87241 atattcaatt gaaaaaccgg gttgtgctcg cacctatggc tggtgtctgc aactctgcgt 87301 tcagattgac tgtaaaggaa ttcggagccg gattggtatg cgctgaaatg gtcagtgaca 87361 aagcgatcct ttacaacaat gcaagaacaa tgggtatgct ttatattgat gaacgtgaga 87421 aaccactgag ccttcaaatt ttcggaggaa aaaaggaaac ccttgtggaa gcggcgaagt 87481 ttgtagacca aaacacaact gctgatatca ttgatattaa catgggatgt cccgtgccga 87541 agattacaaa atgcgatgcg ggagccaaat ggcttctcga tcctgataag atttacgaaa 87601 tggtttctgc agtagtggat gctgttaata agccagttac agtgaaaatg agaatgggct 87661 gggatgaaga ccacattttc gcagtgaaaa atgcacaggc tgtagaacgt gcgggcggta 87721 aagcagtggc gcttcacggc cgtacgagag tgcagatgta cgaaggaacg gcaaactggg 87781 atatcatcaa agaagtaaaa caatcagtat cgattccggt tatcggaaac ggcgatgtta 87841 agacaccgca ggatgctaag cgtatgctcg atgagacagg agtagacggg gtcatgatcg 87901 gacgcgctgc attgggtaac ccgtggatga tttaccgtac ggttcagtat cttgaaacag 87961 gtaaattaaa agaagagccg caagtacgcg aaaaaatggc cgtatgcaaa ctgcatcttg 88021 accgcctgat tgacttaaaa ggtgaaaacg tagcggtaag agaaatgaga aagcacgctg 88081 catggtatct gaaaggcgtg aaaggcaatg cgaacgttcg taatgaaatc aatcattgcg 88141 agacgagaga agagtttgta cagcttttag atgcatttac ggttgaagtt gaggcaaaag 88201 agcttcaaaa tgcaaaagta ggataatact cacctctatt tgctgctcac tgctagtttt 88261 acgctggcag tttttctgct tttttcatga aacaatatct gtaatggagt gataacaatg 88321 agtcaagaag agcataacca tgaagaattg aatgatcagc tgcaagtcag acgcgataaa 88381 atgaatcagc tgagagataa cggcatcgat ccattcggcg cacgttttga aagaactcat 88441 cagtctcaag aagttatttc ggcatatcaa gatctaacca aagaagagtt agaagaaaaa 88501 gcgattgaag ttacaatcgc aggccgcatg atgacaaaac gcggcaaagg aaaagccggc 88561 tttgcccatc ttcaggattt agaaggccaa atccaaatct acgtaagaaa agacagtgtc 88621 ggtgacgacc aatatgaaat cttcaagtct tctgacctcg gtgatcttat cggcgtaacc 88681 ggaaaagtct tcaaaacaaa tgtaggcgaa ttgtctgtta aagcaacttc ctttgaattg 88741 ctgacaaaag cgcttcgtcc gcttcctgac aaataccatg gtttaaaaga cgttgagcag 88801 cgctaccgtc agcgctatct ggatcttatc gtaaacccag acagcaaaca tacgttcatt 88861 acacgaagca agatcattca agctatgaga aggtaccttg atgatcatgg atacttagaa 88921 gtagaaacac ctacaatgca cagcattcct gggggagctt ctgcacgtcc gtttatcact 88981 caccacaacg cgttagacat tccactctat atgcgtattg ctatcgaact gcacctaaaa 89041 cgtctaattg tcggcggttt agaaaaagta tatgaaatcg gccgtgtttt ccgtaacgaa 89101 ggtgtctcta cacgccataa ccctgaattt acaatgattg agttatatga agcatatgcg 89161 gactataaag atatcatgag cttaactgaa aaccttgtcg ctcatatcgc ccaagaagtg 89221 cttggcacaa ctacgattca atacggggaa gagcaaatcg accttaaacc ggagtggaaa 89281 agaatccata tggttgacgc agtcaaagaa gcgaccggcg ttgatttctg ggaagaggtt 89341 actgttgagc aggcgcgtga atatgcaaaa gaacatgaag tagaaattaa agactctatg 89401 acagtaggcc atatcatcaa cgaattcttc gaacaaaaaa ttgaagaaac gcttattcag 89461 ccaacgttta tttacgggca tcctgtagaa atttctcctc ttgctaagaa aaaccctgag 89521 gacccgcgtt ttacagaccg ttttgagctg tttatcgttg gccgtgaaca tgccaacgcg 89581 tttacagagc tgaatgatcc tattgatcaa agagaacgct ttgaagcgca attaaaagag 89641 cgtgaagccg gtaatgatga agctcattta atggatgaag actttgttga agctctggaa 89701 tacggtatgc cgccaacagg aggtttaggc atcggtatcg accgtctggt tatgctgctg 89761 acgaatgccc cttctattcg cgatgtgctg ttattcccgc aaatgagaca acgctaataa 89821 aaaagagcgg tatcctccat agggaaagga tgccgctctt tttaaatccc ttagtatttc 89881 ttcaaaaaaa ctattgcact attatttact aggtggtata ttattattcg ttgccgctaa 89941 acaaggcgat aacgaaaaaa agaacttcaa aaaaagttat tgacttcact gagtcaacga 90001 gttataataa taaagtcgct tgaacgaagt gaacaaaatg atctttgaaa actaaacaag 90061 acaaaacgta cctgttaatt cagtttttaa aaatcgcaca gcgatgtgcg tagtcagtca 90121 aactacttta tcggagagtt tgatcctggc tcaggacgaa cgctggcggc gtgcctaata 90181 catgcaagtc gagcggacag atgggagctt gctccctgat gttagcggcg gacgggtgag 90241 taacacgtgg gtaacctgcc tgtaagactg ggataactcc gggaaaccgg ggctaatacc 90301 ggatggttgt ttgaaccgca tggttcaaac ataaaaggtg gcttcggcta ccacttgcag 90361 atggacccgc ggcgcattag ctagttggtg aggtaatggc tcaccaaggc aacgatgcgt 90421 agccgacctg agagggtgat cggccacact gggactgaga cacggcccag actcctacgg 90481 gaggcagcag tagggaatct tccgcaatgg acgaaagtct gacggagcaa cgccgcgtga 90541 gtgatgaagg ttttcggatc gtaaagctct gttgttaggg aagaacaagt gccgttcgaa 90601 tagggcggta ccttgacggt acctaaccag aaagccacgg ctaactacgt gccagcagcc 90661 gcggtaatac gtaggtggca agcgttgtcc ggaattattg ggcgtaaagg gctcgcaggc 90721 ggtttcttaa gtctgatgtg aaagcccccg gctcaaccgg ggagggtcat tggaaactgg 90781 ggaacttgag tgcagaagag gagagtggaa ttccacgtgt agcggtgaaa tgcgtagaga 90841 tgtggaggaa caccagtggc gaaggcgact ctctggtctg taactgacgc tgaggagcga 90901 aagcgtgggg agcgaacagg attagatacc ctggtagtcc acgccgtaaa cgatgagtgc 90961 taagtgttag ggggtttccg ccccttagtg ctgcagctaa cgcattaagc actccgcctg 91021 gggagtacgg tcgcaagact gaaactcaaa ggaattgacg ggggcccgca caagcggtgg 91081 agcatgtggt ttaattcgaa gcaacgcgaa gaaccttacc aggtcttgac atcctctgac 91141 aatcctagag ataggacgtc cccttcgggg gcagagtgac aggtggtgca tggttgtcgt 91201 cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct tgatcttagt 91261 tgccagcatt cagttgggca ctctaaggtg actgccggtg acaaaccgga ggaaggtggg 91321 gatgacgtca aatcatcatg ccccttatga cctgggctac acacgtgcta caatggacag 91381 aacaaagggc agcgaaaccg cgaggttaag ccaatcccac aaatctgttc tcagttcgga 91441 tcgcagtctg caactcgact gcgtgaagct ggaatcgcta gtaatcgcgg atcagcatgc 91501 cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccacga gagtttgtaa 91561 cacccgaagt cggtgaggta accttttagg agccagccgc cgaaggtggg acagatgatt 91621 ggggtgaagt cgtaacaagg tagccgtatc ggaaggtgcg gctggatcac ctcctttcta 91681 aggatatttt acggaatata agaccttggg tcttataaac agaacgttcc ctgtcttgtt 91741 tagttttgaa ggatcattcc ttcgaaacgt gttctttgaa aactagataa cagtagacat 91801 cacattcaag taatacaaga tatcacatag tgattctttt taacggttaa gttagaaagg 91861 gcgcacggtg gatgccttgg cactaggagc cgatgaagga cgggacgaac accgatatgc 91921 ttcggggagc tgtaagcaag ctttgatccg gagatttccg aatggggaaa cccaccactc 91981 gtaatggagt ggtatccata tctgaattca taggatatga gaaggcagac ccggggaact 92041 gaaacatcta agtacccgga ggaagagaaa gcaaatgcga ttccctgagt agcggcgagc 92101 gaaacgggat tagcccaaac caagaggctt gcctcttggg gttgtaggac actctgtacg 92161 gagttacaaa ggaacgaggt agatgaagag gtctggaaag gcccgccata ggaggtaaca 92221 gccctgtagt caaaacttcg ttctctcctg agtggatcct gagtacggcg gaacacgtga 92281 aattccgtcg gaatccggga ggaccatctc ccaaggctaa atactcccta gtgaccgata 92341 gtgaaccagt accgtgaggg aaaggtgaaa agcaccccgg aaggggagtg aaagagatcc 92401 tgaaaccgtg tgcctacaag tagtcagagc ccgttaacgg gtgatggcgt gccttttgta 92461 gaatgaaccg gcgagttacg atcccgtgca aggttaagca gaagatgcgg agccgcagcg 92521 aaagcgagtc tgaatagggc gcatgagtac gtggtcgtag acccgaaacc aggtgatcta 92581 cccatgtcca gggtgaagtt caggtaacac tgaatggagg cccgaaccca cgcacgttga 92641 aaagtgcggg gatgaggtgt gggtaggggt gaaatgccaa tcgaacctgg agatagctgg 92701 ttctctccga aatagcttta gggctagcct caaggtaaga gtcttggagg tagagcactg 92761 attggactag gggcccctac cgggttaccg aattcagtca aactccgaat gccaatgact 92821 tatccttggg agtcagactg cgagtgataa gatccgtagt cgaaagggaa acagcccaga 92881 ccgccagcta aggtcccaaa gtatacgtta agtggaaaag gatgtggagt tgcttagaca 92941 accaggatgt tggcttagaa gcagccacca tttaaagagt gcgtaatagc tcactggtcg 93001 agtgactctg cgccgaaaat gtaccggggc taaacgtatc accgaagctg cggactgttc 93061 ttcgaacagt ggtaggagag cgttctaagg gctgtgaagc cagaccggaa ggactggtgg 93121 agcgcttaga agtgagaatg ccggtatgag tagcgaaaga ggggtgagaa tcccctccac 93181 cgaatgccta aggtttcctg aggaaggctc gtccgctcag ggttagtcgg gacctaagcc 93241 gaggccgaaa ggcgtaggcg atggacaaca ggttgatatt cctgtaccac ctcctcacca 93301 tttgagcaat ggggggacgc aggaggatag ggtaagcgcg gtattggata tccgcgtcca 93361 agcagttagg ctgggaaata ggcaaatccg tttcccataa ggctgagctg tgatggcgag 93421 cgaaatatag tagcgaagtt cctgattcca cactgccaag aaaagcctct agcgaggtga 93481 gaggtgcccg taccgcaaac cgacacaggt aggcgaggag agaatcctaa ggtgatcgag 93541 agaactctcg ttaaggaact cggcaaaatg accccgtaac ttcgggagaa ggggtgctct 93601 gttagggtgc aagcccgaga gagccgcagt gaataggccc aggcgactgt ttagcaaaaa 93661 cacaggtctc tgcgaagccg taaggcgaag tataggggct gacgcctgcc cggtgctgga 93721 aggttaagag gagcgcttag cgtaagcgaa ggtgcgaatt gaagccccag taaacggcgg 93781 ccgtaactat aacggtccta aggtagcgaa attccttgtc gggtaagttc cgacccgcac 93841 gaaaggcgca acgatctggg cactgtctca acgagagact cggtgaaatt atagtacctg 93901 tgaagatgca ggttacccgc gacaggacgg aaagaccccg tggagcttta ctgcagcctg 93961 atattgaatg ttggtacagc ttgtacagga taggtaggag ccttggaaac cggagcgcca 94021 gcttcggtgg aggcatcggt gggatactac cctggctgta ttgaccttct aacccgccgc 94081 ccttatcggg cggggagaca gtgtcaggtg ggcagtttga ctggggcggt cgcctcctaa 94141 aaggtaacgg aggcgcccaa aggttccctc agaatggttg gaaatcattc gcagagtgta 94201 aaggcacaag ggagcttgac tgcgagacct acaagtcgag cagggacgaa agtcgggctt 94261 agtgatccgg tggttccgca tggaagggcc atcgctcaac ggataaaagc taccccgggg 94321 ataacaggct tatctccccc aagagtccac atcgacgggg aggtttggca cctcgatgtc 94381 ggctcatcgc atcctggggc tgtagtcggt cccaagggtt gggctgttcg cccattaaag 94441 cggtacgcga gctgggttca gaacgtcgtg agacagttcg gtccctatcc gtcgcgggcg 94501 caggaaattt gagaggagct gtccttagta cgagaggacc gggatggacg caccgctggt 94561 gtaccagttg ttctgccaag ggcatcgctg ggtagctatg tgcggacggg ataagtgctg 94621 aaagcatcta agcatgaagc ccccctcaag atgagatttc ccattccgca aggaagtaag 94681 atccctgaaa gatgatcagg ttgataggtc tgaggtggaa gtgtggcgac acatggagct 94741 gacagatact aatcgatcga ggacttaacc atatttttga atgatgtcac atctgttatc 94801 tagttttgag agaacactct caatttgttt ggtggcgata gcgaagaggt cacacccgtt 94861 cccataccga acacggaagt taagctcttc agcgccgatg gtagtcgggg gtttccccct 94921 gtgagagtag gacgccgcca agcaattgca cgttagtgca attatggagg attagctcag 94981 ctgggagagc atctgcctta caagcagagg gtcggcggtt cgagcccgtc atcctccacc 95041 attatgccgg tgtagctcaa ttggtagagc aactgacttg taatcagtag gttgggggtt 95101 caagtcctct tgccggcacc acttttatat gatataatac tcaagtctct tgtagaagag 95161 ccattagctc agttggtaga gcatctgact tttaatcaga gggtcgaagg ttcgagtcct 95221 tcatggctca ccattttacg cgggtgtggc ggaattggca gacgcgctag acttaggatc 95281 tagtgtcttt atgacgtggg ggttcaagtc ccttcacccg cattatatag gataacagtt 95341 agaaaaactg gacatcctgt ctgcggaagt agttcagtgg tagaacacca ccttgccaag 95401 gtgggggtcg cgggttcgaa tcccgtcttc cgctccaact ataccatcca cgccggggtg 95461 gtggaattgg cagacacaca ggacttaaaa tcctgcggta ggtgactacc gtgccggttc 95521 aagtccggcc ctcggcatta tgttttgcgc ccgtagctca attggataga gcgtttgact 95581 acggatcaaa aggttagggg ttcgactcct ctcgggcgcg ccatatcttt taatagaata 95641 gataggaaat cgggaagtag ctcagcttgg tagagcacat ggtttgggac catggggtcg 95701 caggttcgaa tcctgtcttc ccgaccattt ttttatgggg ccttagctca gctgggagag 95761 cgcctgcttt gcacgcagga ggtcagcggt tcgatcccgc taggctccac caaaagtttt 95821 taaaaaagtt gttgactttg aagaagtgac gttgtatact aataaagttg ctttaacaaa 95881 gcggacaaac aaaatgatct ttgaaaacta aacaagacaa aacgtacctg ttaattcagt 95941 ttttaaaaat cgcacagcga tgtgcgtagt cagtcaaact actttatcgg agagtttgat 96001 cctggctcag gacgaacgct ggcggcgtgc ctaatacatg caagtcgagc ggacagatgg 96061 gagcttgctc cctgatgtta gcggcggacg ggtgagtaac acgtgggtaa cctgcctgta 96121 agactgggat aactccggga aaccggggct aataccggat ggttgtttga accgcatggt 96181 tcaaacataa aaggtggctt cggctaccac ttacagatgg acccgcggcg cattagctag 96241 ttggtgaggt aacggctcac caaggcaacg atgcgtagcc gacctgagag ggtgatcggc 96301 cacactggga ctgagacacg gcccagactc ctacgggagg cagcagtagg gaatcttccg 96361 caatggacga aagtctgacg gagcaacgcc gcgtgagtga tgaaggtttt cggatcgtaa 96421 agctctgttg ttagggaaga acaagtaccg ttcgaatagg gcggtacctt gacggtacct 96481 aaccagaaag ccacggctaa ctacgtgcca gcagccgcgg taatacgtag gtggcaagcg 96541 ttgtccggaa ttattgggcg taaagggctc gcaggcggtt tcttaagtct gatgtgaaag 96601 cccccggctc aaccggggag ggtcattgga aactggggaa cttgagtgca gaagaggaga 96661 gtggaattcc acgtgtagcg gtgaaatgcg tagagatgtg gaggaacacc agtggcgaag 96721 gcgactctct ggtctgtaac tgacgctgag gagcgaaagc gtggggagcg aacaggatta 96781 gataccctgg tagtccacgc cgtaaacgat gagtgctaag tgttaggggg tttccgcccc 96841 ttagtgctgc agctaacgca ttaagcactc cgcctgggga gtacggtcgc aagactgaaa 96901 ctcaaaggaa ttgacggggg cccgcacaag cggtggagca tgtggtttaa ttcgaagcaa 96961 cgcgaagaac cttaccaggt cttgacatcc tctgacaatc ctagagatag gacgtcccct 97021 tcgggggcag agtgacaggt ggtgcatggt tgtcgtcagc tcgtgtcgtg agatgttggg 97081 ttaagtcccg caacgagcgc aacccttgat cttagttgcc agcattcagt tgggcactct 97141 aaggtgactg ccggtgacaa accggaggaa ggtggggatg acgtcaaatc atcatgcccc 97201 ttatgacctg ggctacacac gtgctacaat ggacagaaca aagggcagcg aaaccgcgag 97261 gttaagccaa tcccacaaat ctgttctcag ttcggatcgc agtctgcaac tcgactgcgt 97321 gaagctggaa tcgctagtaa tcgcggatca gcatgccgcg gtgaatacgt tcccgggcct 97381 tgtacacacc gcccgtcaca ccacgagagt ttgtaacacc cgaagtcggt gaggtaacct 97441 tttaggagcc agccgccgaa ggtgggacag atgattgggg tgaagtcgta acaaggtagc 97501 cgtatcggaa ggtgcggctg gatcacctcc tttctaagga tattttacgg aatataagac 97561 cttgggtctt ataaacagaa cgttccctgt cttgtttagt tttgaaggat cattccttcg 97621 aaacgtgttc tttgaaaact agataacagt agacatcaca ttcaagtaat acaagatatc 97681 acatagtgat tctttttaac ggttaagtta gaaagggcgc acggtggatg ccttggcact 97741 aggagccgat gaaggacggg acgaacaccg atatgcttcg gggagctgta agcaagcttt 97801 gatccggaga tttccgaatg gggaaaccca ccactcgtaa tggagtggta tccatatctg 97861 aattcatagg atatgagaag gcagacccgg ggaactgaaa catctaagta cccggaggaa 97921 gagaaagcaa atgcgattcc ctgagtagcg gcgagcgaaa cgggatcagc ccaaaccaag 97981 aggcttgcct cttggggttg taggacactc tgtacggagt tacaaaggaa cgaggtagat 98041 gaagaggtct ggaaaggccc gccataggag gtaacagccc tgtagtcaaa acttcgttct 98101 ctcctgagtg gatcctgagt acggcggaac acgtgaaatt ccgtcggaat ccgggaggac 98161 catctcccaa ggctaaatac tccctagtga ccgatagtga accagtaccg tgagggaaag 98221 gtgaaaagca ccccggaagg ggagtgaaag agatcctgaa accgtgtgcc tacaagtagt 98281 cagagcccgt taacgggtga tggcgtgcct tttgtagaat gaaccggcga gttacgatcc 98341 cgtgcaaggt taagcagaag atgcggagcc gcagcgaaag cgagtctgaa tagggcgcat 98401 gagtacgtgg tcgtagaccc gaaaccaggt gatctaccca tgtccagggt gaagttcagg 98461 taacactgaa tggaggcccg aacccacgca cgttgaaaag tgcggggatg aggtgtgggt 98521 aggggtgaaa tgccaatcga acctggagat agctggttct ctccgaaata gctttagggc 98581 tagcctcaag gtaagagtct tggaggtaga gcactgattg gactaggggc ccctaccggg 98641 ttaccgaatt cagtcaaact ccgaatgcca atgacttatc cttgggagtc agactgcgag 98701 tgataagatc cgtagtcgaa agggaaacag cccagaccgc cagctaaggt cccaaagtat 98761 acgttaagtg gaaaaggatg tggagttgct tagacaacca ggatgttggc ttagaagcag 98821 ccaccattta aagagtgcgt aatagctcac tggtcgagtg actctgcgcc gaaaatgtac 98881 cggggctaaa cgtatcaccg aagctgcgga ctgttcttcg aacagtggta ggagagcgtt 98941 ctaagggctg tgaagccaga ccggaaggac tggtggagcg cttagaagtg agaatgccgg 99001 tatgagtagc gaaagagggg tgagaatccc ctccaccgaa tgcctaaggt ttcctgagga 99061 aggctcgtcc gctcagggtt agtcgggacc taagccgagg ccgaaaggcg taggcgatgg 99121 acaacaggtt gatattcctg taccacctcc tcaccatttg agcaatgggg ggacgcagga 99181 ggatagggta agcgcggtat tggatatccg cgtccaagca gttaggctgg gaaataggca 99241 aatccgtttc ccataaggct gagctgtgat ggcgagcgaa atatagtagc gaagttcctg 99301 attccacact gccaagaaaa gcctctagcg aggtgagagg tgcccgtacc gcaaaccgac 99361 acaggtaggc gaggagagaa tcctaaggtg atcgagagaa ctctcgttaa ggaactcggc 99421 aaaatgaccc cgtaacttcg ggagaagggg tgctctgtta gggtgcaagc ccgagagagc 99481 cgcagtgaat aggcccaggc gactgtttag caaaaacaca ggtctctgcg aagccgtaag 99541 gcgaagtata ggggctgacg cctgcccggt gctggaaggt taagaggagc gcttagcgta 99601 agcgaaggtg cgaattgaag ccccagtaaa cggcggccgt aactataacg gtcctaaggt 99661 agcgaaattc cttgtcgggt aagttccgac ccgcacgaaa ggcgcaacga tctgggcact 99721 gtctcaacga gagactcggt gaaattatag tacctgtgaa gatgcaggtt acccgcgaca 99781 ggacggaaag accccgtgga gctttactgc agcctgatat tgaatgttgg tacagcttgt 99841 acaggatagg taggagcctt ggaaaccgga gcgccagctt tggtggaggc atcggtggga 99901 tactaccctg gctgtattga ccttctaacc cgccgccctt atcgggcggg gagacagtgt 99961 caggtgggca gtttgactgg ggcggtcgcc tcctaaaagg taacggaggc gcccaaaggt 100021 tccctcagaa tggttggaaa tcattcgcag agtgtaaagg cacaagggag cttgactgcg 100081 agacctacaa gtcgagcagg gacgaaagtc gggcttagtg atccggtggt tccgcatgga 100141 agggccatcg ctcaacggat aaaagctacc ccggggataa caggcttatc tcccccaaga 100201 gtccacatcg acggggaggt ttggcacctc gatgtcggct catcgcatcc tggggctgta 100261 gtcggtccca agggttgggc tgttcgccca ttaaagcggt acgcgagctg ggttcagaac 100321 gtcgtgagac agttcggtcc ctatccgtcg cgggcgcagg aaatttgaga ggagctgtcc 100381 ttagtacgag aggaccggga tggacgcacc gctggtgtac cagttgttct gccaagggca 100441 tcgctgggta gctatgtgcg gacgggataa gtgctgaaag catctaagca tgaagccccc 100501 ctcaagatga gatttcccat tccgcaagga agtaagatcc ctgaaagatg atcaggttga 100561 taggtctgag gtggaagtgt ggcgacacat ggagctgaca gatactaatc gatcgaggac 100621 ttaaccatat ttttgaatga tgtcacatct gttatctagt tttgagagaa cactctcaat 100681 ttgtttggtg gcgatagcga agaggtcaca cccgttccca taccgaacac ggaagttaag 100741 ctcttcagcg ccgatggtag tcgggggttt ccccctgtga gagtaggacg ccgccaagca 100801 agcttaaacc cagctcaatg agctgggttt tttgtatttt ggtttattgg tatcataaaa 100861 ttccacttaa ctgtataata taataacttt ataccgaatt ttaaatcagc aatcaggttt 100921 tgtggaccgg gaaaatggaa ataatgaagg atagagcgag aaagttgaaa attctcgaga 100981 aacggcttat agtaagatta aagtcaaata tagtcaaagt cagtaaagga gggggttgag 101041 tgggacataa tatttctgac atcattgaac aatatttaaa acgagtgtta gatcaaaatg 101101 gcaaggaaat tttagagatt aaacgaagtg aaattgcaga taaatttcaa tgcgttcctt 101161 cccaaataaa ttatgtcatc aacaccagat ttacaagcga aagaggatat attgttgaga 101221 gcaaacgcgg gggcggcggt tacatcagaa tcattaaaat taaaatgaac aatgaagttg 101281 tcctgatcaa taatataatt tctcaaatta atacccattt gtctcaagca gcctctgatg 101341 acattatttt aaggctatta gaagacaagg taatttcaga aagagaagca aaaatgatgg 101401 tcagcgtaat ggaccgctca gttttacaca ttgacttacc tgaacgtgat gaattaagag 101461 cgagaatgat gaaggcaatg ctgacttctt taaaattaaa ataagcgggt gaaaagattg 101521 atttgtcaag agtgccacga gagaccagcc acttttcact ttacaaaggt tgttaacgga 101581 gaaaaaatag aagttcatat ttgtgaacaa tgtgccaaag aaaatagtga ttcatatggt 101641 ataagtgcaa atcagggttt ctctattcat aatttacttt cgggtttact gaacatggat 101701 tcttcatttc aaaatgcagg aactcaaatg ttcagtcact cggagcaaat atctgcttgt 101761 ccgaaatgcg gaatgacttt tcagcaattc agaaaaattg gccgttttgg atgttctgaa 101821 tgttacaaaa catttcatag caacattaca ccaatcctac gtaaagtgca cagcggaaac 101881 actgtgcatg caggtaagat accgaaacga ataggcggca atcttcatgt cagacggcag 101941 attgatatgc taaaaaagga attagaatcc ttaatccatc aagaagaatt tgaaaatgca 102001 gctcatgtaa gagatcaaat tcgtttatta gaacaatcac tcaaaagtac agatagtgag 102061 gaggaacagg agtaatgtcg ctaaagcatt ttattcagga cgcactaagc agttggatga 102121 agcagaaagg acctgaaagt gacattgtac tcagcagccg catacgttta gcaagaaact 102181 ttgagcatat tcggttccct acgcggtatt ccaatgaaga agcctcatcc atcatacagc 102241 aatttgaaga tcagttttca gagcaagaaa ttcccggaat cggcaaattt gttttgatta 102301 gaatgaatga tgcacagcct ttagaaaagc gtgtacttgt tgaaaaacat ctaatcagcc 102361 cgaatttgac agagtctcct tttggcggct gtttgctttc tgaaaatgag gaagtaagcg 102421 tcatgctaaa tgaagaggac catattagaa ttcagtgtct tttccctgga tttcagcttt 102481 tagaagcaat gaaagccgca aaccaggtcg acgactggat tgaagaaaaa gttgattatg 102541 cattcaatga gcaaagagga tacttaacca gctgtcctac aaacgtaggt actggtttaa 102601 gggcttcggt catgatgcat ctgccggcgc tggttttaac taggcaaata aatcgaatta 102661 taccggcaat taatcaatta ggcttagttg ttagaggaat ttatggggaa ggcagcgaag 102721 cagtagggaa tatctttcaa atttcaaatc agatcacgct tggtaagtca gagcaggata 102781 ttgtagagga tcttaacagt gttgctgctc agttgattga acaagaacga tctgcccgag 102841 aagcgattta tcaaacttct aaaatcgaac ttgaggatcg ggtatatcgg tcatatgggg 102901 tcttgtctaa ttgccggatg atagaatcga aagaaactgc aaagtgcctt tcagatgttc 102961 ggttaggcat agacttaggc ataataaaag gactttcaag caacatactt aacgaactta 103021 tgattttgac gcagccaggg tttttacagc aatactcggg aggcgctttg cgaccgaacg 103081 aaagggacat tcgaagagcg gctctcatca gagaacggct tcacttagaa atgaatggga 103141 aaagacagga ggatgaatcg atatgatgtt tggaagattt acagaacgag ctcaaaaagt 103201 actggcgcta gcacaggaag aagcacttcg gttaggtcat aataacattg gcactgagca 103261 tattttatta ggactggtaa gagaaggaga gggcattgct gctaaagctc ttcaagcgct 103321 tggactcggt tcagaaaaaa ttcagaaaga agtagaaagt ttgatcgggc gcgggcagga 103381 aatgtctcaa acgattcatt atactcctag agctaaaaaa gtcattgagc tttcaatgga 103441 tgaggcaaga aaactcggtc attcttatgt gggaacagaa catattcttc ttggtctgat 103501 tcgtgaagga gaaggtgttg ctgcgagagt tctgaataat ctcggtgtca gcttaaataa 103561 agcaagacag caggtgctcc agcttctagg aagtaatgaa acaggatcat cagcggcagg 103621 aacaaacagc aatgcgaata cgcctacgct tgacagcttg gcaagagact taactgctat 103681 tgcgaaggaa gacagccttg accctgtaat cggcagaagc aaggagatcc agcgtgtcat 103741 tgaagtgtta agccgcagaa cgaaaaacaa ccctgttctc attggggaac caggtgtagg 103801 taaaacggct atcgcagaag gtttggcaca gcaaattatc aataatgaag tacccgaaat 103861 tttgcgtgat aaacgtgtga tgacattaga catgggaaca gttgttgccg gcacaaaata 103921 ccgcggagaa tttgaggatc gcctgaagaa ggtcatggat gaaattcgcc aggcaggaaa 103981 tatcattcta ttcatcgatg agctccatac attaatcggg gcaggcggag cagaaggtgc 104041 tattgatgca tctaatattt taaaaccttc acttgctcgt ggcgaactcc aatgtattgg 104101 tgcaacgact cttgatgagt accgtaaata tattgaaaaa gatgcagcac tggaacgccg 104161 ttttcagccg attcaggttg atcagccatc tgtagatgaa agtattcaaa ttttacaagg 104221 tctgcgtgac agatacgaag cccaccaccg cgtttctatc actgatgatg ccattgaagc 104281 tgcggttaag ctttctgaca gatatatttc tgaccgcttc cttccggata aagcaattga 104341 cttgatcgat gaagcgggtt caaaggtgag actgcgctca tttacaacgc ctcctaactt 104401 aaaagagctt gagcagaagc ttgatgaggt tcgtaaagag aaggatgcgg cagtgcaaag 104461 ccaagagttt gaaaaagctg cttccttgcg tgatactgaa caacgcctgc gcgagcaagt 104521 agaggatacg aagaaatcat ggaaagagaa gcaagggcag gaaaactcag aggttactgt 104581 ggatgatatt gcgatggttg tatccagctg gaccggtgtg cctgtatcta aaatcgccca 104641 aactgaaact gataagcttc tcaatatgga aaacattctt cactcccgtg tcatcggcca 104701 ggatgaagca gttgtagcgg ttgcaaaagc cgtcagacgt gcaagagcag gattgaaaga 104761 tcctaaacgc ccaatcggct cattcatttt cttaggccct acaggtgtag gtaaaacaga 104821 acttgcacga gcacttgctg aatccatttt tggcgatgaa gaatccatga tcagaattga 104881 tatgtctgaa tacatggaaa aacattcaac ttcaagactt gttggttcac ctccgggtta 104941 tgtgggatat gatgaaggcg gtcaattgac agagaaagtc agaagaaaac cttactctgt 105001 cgtgcttctt gatgagatcg agaaagcgca ccctgatgtc ttcaatatcc ttctgcaagt 105061 tcttgaagac ggacgattga ctgattctaa aggacgcaca gtcgatttcc gcaataccat 105121 tctgatcatg acatcaaacg tcggagcaag tgagctaaaa cgcaataaat atgtcggctt 105181 taacgttcag gatgaaactc aaaatcataa agacatgaaa gataaagtga tgggtgaatt 105241 aaaacgagcg ttcagacctg agttcatcaa ccgtattgat gaaatcattg tcttccattc 105301 acttgagaaa aaacatctca ctgagattgt gtcattaatg tctgatcaat taacgaaacg 105361 cctgaaagaa caagatcttt ctatcgaatt gacagatgct gcaaaagcga aagtcgcgga 105421 agagggcgtt gacctggaat acggtgcccg tccgttaaga agagcgatcc aaaaacatgt 105481 cgaggatcgt ttatctgaag aactcctcag aggaaatatt cataaaggac agcatattgt 105541 tcttgatgta gaagatggcg aatttgtcgt aaaaacgact gctaaaacga attaatatag 105601 aagacggaaa tgaggcatac agcatgtaag tgtatgcctc actttcatat caagaaatag 105661 aacaagggag aggtcttaca ctatatatgg ctaaaacaaa atcgaagttc atctgccaat 105721 cctgcggcta cgagtctcca aaatggatgg ggaaatgtcc gggctgtggt gcttggaata 105781 caatggtgga agaaatgatt aaaaaagcac cggccaatcg gagagcggct ttttctcatt 105841 ctgttcaaac tgtacagaaa ccttcaccta ttacatcaat cgaaacatca gaagaacccc 105901 gcgtcaaaac ccagcttggc gagtttaaca gagtactcgg cggaggtgtc gttaaaggct 105961 ccctcgtttt aattggcggt gatcctggta tcggaaagtc aacgctatta ctgcaggttt 106021 ccgctcaatt atcaggctca tcaaacagtg tcctgtatat ttcgggagaa gaatctgtaa 106081 agcaaacgaa gctgcgagca gaccgtctcg gcattaataa tccgtcactg catgttttat 106141 ctgaaaccga tatggagtat atttcgtctg ctatacaaga gatgaatcca tcgtttgtcg 106201 ttgttgactc tattcaaacg gtttaccaaa gcgatattac atctgctcca ggcagtgtgt 106261 cacaggtcag agaatgtacc gctgagctga tgaaaattgc aaaaacaaaa ggtattccga 106321 tttttatcgt agggcacgtg acgaaagaag ggtctattgc aggtccgaga ctgttggagc 106381 atatggttga cactgtttta tattttgaag gagaacgcca ccatactttc cgtattttgc 106441 gggctgtaaa aaaccgtttc ggatctacaa acgaaatggg cattttcgaa atgcgggaag 106501 aggggctcac tgaggttttg aatccttcgg aaattttctt agaagaacgc tctgctggtt 106561 ccgcaggctc gagtatcact gcctctatgg agggcactag accgattctc gttgaaattc 106621 aggcactcat ctcgccaaca agttttggca acccaaggcg tatggcaacg ggaatagacc 106681 ataacagggt ttctctgtta atggctgtgt tagaaaaaag agttggactg ctgctgcaaa 106741 atcaggatgc ttatttgaaa gtggctggcg gcgttaagct tgatgaaccg gcaattgatc 106801 ttgcgattgt gattagtatt gcatcaagct ttagagacac acctccaaat cctgcagatt 106861 gttttattgg agaagtggga ttaaccggag aagtccggcg ggtttcaaga attgaacagc 106921 gtgtgaaaga agcggcaaag cttggtttta aacgcatgat catacccgcg gcaaatctgg 106981 atggatggac aaaaccaaaa gggattgagg ttatcggagt agcaaatgtt gcagaagcgc 107041 ttcgtacttc attaggagga taatagatgg aaaaagagaa aaaaggggcg aaacacgagt 107101 tagacctgtc atctatattg cagtttgttg ctccgggtac accgctcaga gcggggatgg 107161 aaaacgtctt gagagcaaat acaggcggtc tgattgttgt tggatataat gataaagtaa 107221 aagaagtggt ggacggcggc tttcacataa acacggcttt ttctccggcg catttatatg 107281 agctggctaa aatggatgga gcgatcattt taagtgattc tggtcaaaag atcctatacg 107341 cgaatactca gctgatgccg gatgccacaa tttcttcatc agaaacagga atgcggcaca 107401 gaactgccga aagagtagct aagcaaactg gctgtcttgt aatcgccatt tctgaaagaa 107461 gaaatgtcat aacgttatat caggaaaaca tgaagtatac actaaaagac ataggattta 107521 ttttaaccaa ggcgaaccaa gccattcaaa cacttgaaaa atataagaca atcctcgata 107581 aaacgattaa tgcactgaac gcgttagagt ttgaggaact tgttaccttc agtgatgtct 107641 tgtctgtcat gcatcgttat gaaatggtac tgagaatcaa aaacgaaatt aatatgtata 107701 tcaaagagct ggggacagaa gggcatctga tcaaactgca agtcattgaa ttgattacgg 107761 atatggaaga agaggccgct ttatttatta aggactatgt aaaagaaaag attaaagatc 107821 cgtttgttct cttgaaggag ctgcaggata tgtccagtta tgatctgctg gatgattcca 107881 ttgtgtataa gcttctcggt taccctgctt ctactaatct tgatgattat gtattgccga 107941 gaggatacag gctgttaaat aagataccgc gtcttccgat gccgattgtt gaaaatgttg 108001 tagaagcatt tggagtcctg ccaaggatta ttgaggcgag tgcagaagaa ttagatgaag 108061 tagagggaat cggtgaagta cgagcccaaa aaatcaaaaa aggattaaaa cgcctgcaag 108121 agaagcatta tttagacaga caactgtgat ttcggttaaa accttatgaa tacgggtata 108181 ttaatgttgg tttttgttta ttctgatatt cgtaggatgc ataagacttt gtgaaattaa 108241 aatgttaaaa aaggaggtgg gggtatgtta aaacgaatag ttcaggcgtt cttcattatt 108301 tttggcggcg ttgttggtat atttttgata cctgaattgt ttgtactgtt aaatatacag 108361 gacatacctt taataacaaa cgcatatacg tctgcggcaa taggagcaat tatctttttt 108421 ctcatcagta tatggggtac agaatacgtt gtgaactggg tgaagtggat agaggattca 108481 ttgttaaaag cgccggttcc agatttgtta tttggaagtc ttggcttagt ttttggactt 108541 ataattgctt atcttatcgt aaatgttatt cctttagaca atatacctta ccgcatattc 108601 agcacaataa ttcctgtatt tttggctttc ttcctcggtt atctcggctt ccaggtgggc 108661 tttaagaaaa aggatgaatt gatcagcctg ttttccattt ccgccagaat gcaaaagaaa 108721 aaaggaacag ctgatgaaga acatgaggtt caagacaaga agctgaaaat tttggacact 108781 agtgttatta ttgatgggag aatagcagat atttgtcaga ctggtttttt agagggagtt 108841 atcgtgattc cgcagtttgt ccttgaggaa ttgcagcata ttgcagactc ttcagatgtt 108901 ttaaaacgaa acagaggacg ccgcggtctt gatatcctga accgcattca gaaagaatta 108961 gacattgaag ttgaaattta cgaaggcgac tttgaagata ttcaggaggt tgacagcaag 109021 ctcgtcaaac ttgctaagct gacatccggg gtcgttgtga cgaatgattt taatttaaat 109081 aaagtgtgcg agcttcagaa ggtagcagta ttaaacatta atgaccttgc caatgcggtt 109141 aagcctgttg tgcttcctgg cgaggaaatg aatgttcagg tcattaagga cgggaaagag 109201 cataatcagg gagttgccta cttggatgac ggtacgatga ttgtcgttga agaaggacgg 109261 aattatatcg gcaagcatat tgatgtactc gtcacaagtg tgctgcagac agcagcggga 109321 cgaatgattt ttgcgaagcc taagctgttg gagaaggcgc tgtaaaggga gaagaaacaa 109381 tgagttatga tgtggtgatt cctgcagccg gacagggaaa gcggatgaag gcagggagaa 109441 ataaactgtt cattgagctg aagggagacc cggtgatcat acacacgtta agagtgtttg 109501 acagccaccg gcagtgcgat aaaatcattt tggtgattaa cgagcaggag cgggagcact 109561 ttcagcaatt gctgtccgat tacccgtttc aaacttcaat tgagcttgtt gcaggcggag 109621 atgagcgaca gcacagtgtg tataaggggc tgaaagccgt aaagcaggaa aagattgtcc 109681 ttgtacatga cggtgcccgt ccatttataa aacatgaaca aattgacgaa ctgatcgcag 109741 aggcggaaca gacaggagcg gccatccttg ctgttccggt aaaagatacg attaaacgcg 109801 ttcaagattt acaagtcagt gagacgattg aacgttcaag cttgtgggct gtccaaacgc 109861 cacaagcttt tcgtctttct ttattgatga aggctcacgc tgaggccgag cgcaagggat 109921 ttttagggac ggatgacgcc agcctcgttg aacagatgga gggcggttcg gtccgtgttg 109981 tagaaggcag ctatacaaat attaagctga cgacgccaga cgatttgacg tcagctgaag 110041 ctatcatgga atcagaaagt gggaataaac atgtttagaa ttggacaagg atttgatgtg 110101 catcaattag tggagggccg tcctctcatt attggcggaa ttgaaatccc gtacgaaaaa 110161 gggctgcttg gccattctga tgcagacgta ttgttgcata ccgtcgctga cgcctgcctg 110221 ggagctgtgg gtgaaggaga cataggcaag cattttcctg acacagatcc cgagttcaag 110281 gacgcagatt ctttcaaatt acttcagcat gtctggggaa tcgtgaaaca gaaggggtat 110341 gtccttggga acattgattg caccatcata gcgcaaaagc cgaagatgct gccgtacata 110401 gaagatatga gaaaaagaat tgctgaaggc cttgaggcag atgtttctca agtaaatgta 110461 aaagcaacaa cgacagaaaa gcttggattt acaggccggg cggaaggaat agcggctcag 110521 gcgacagtac tgatacaaaa aggctaactt gttttgatgc cgggtctatt tggtggtaga 110581 atagattcat acatttttgc ctgaggccat acatgacatg aaaggaagta tttgaaaatg 110641 ggaaacgaag tacgcgtccg ttatgcaccg agtccaaccg gacatttgca tattggaaat 110701 gccagaacgg cgctttttaa ttatttattt gcccgcaatc aaggcggtaa gtttatcatt 110761 cgagttgagg atactgataa aaagcgcaat attgagggcg gagaacaaag ccagctgaat 110821 tatctgaagt ggctaggtat tgactgggat gagagtgtgg atgtcggagg agagtacggt 110881 ccataccgtc agtcagagcg taacgatatc tataaagtgt actatgaaga gcttcttgaa 110941 aaagggcttg cttataaatg ttactgtacg gaagaagagc ttgaaaaaga gcgtgaagaa 111001 cagattgccc gcggagaaat gcctcgttat tccggaaaac acagagacct gactcaggaa 111061 gaacaggaga aatttatcgc cgaaggcaga aaaccaagta ttcgtttccg tgtgccggaa 111121 ggaaaagtca tcgccttcaa cgacatcgta aaaggcgaaa tttcttttga atcagatggc 111181 atcggcgact tcgttattgt gaaaaaggac ggaacgccta cttataactt cgcggtagct 111241 attgatgact acttaatgaa aatgacacac gtgctgcgcg gtgaggatca tatttctaac 111301 acaccgaaac agattatgat ctatcaagca ttcgggtggg atattcctca gttcggacac 111361 atgacgctga ttgtaaacga aagccgtaaa aagctcagca aacgtgatga atccattatt 111421 caattcatcg agcagtacaa agagcttggc tacctgccag aagcgctgtt caactttatc 111481 ggcttgttag gctggtcacc ggttggagaa gaagagcttt tcacaaaaga gcagtttatt 111541 gaaatttttg atgtaaatcg tttatctaaa tcaccagctt tgtttgatat gcataagcta 111601 aaatgggtta acaaccaata tgtgaagaag ctggatcttg atcaggttgt tgaactgacg 111661 cttccgcatt tgcaaaaagc cggcaaagtt ggcactgagc tttctgctga agaacaagaa 111721 tgggttcgta aactgatttc cctgtatcat gagcaattaa gctacggtgc ggaaattgtt 111781 gagctgactg atttgttctt tacggatgag atcgagtata atcaagaagc gaaagctgtt 111841 ctggaagaag aacaggttcc tgaagtgctc agcacattcg cagcgaagct tgaagagctt 111901 gaggagttca ctccggataa tatcaaagca tcgatcaaag cagtgcagaa agaaactggc 111961 cataaaggga aaaaactgtt tatgccgatt cgtgttgctg taacagggca aactcacggt 112021 ccggaactgc cgcaatcaat tgaattgatc ggtaaagaga ctgcaattca gcgtttaaag 112081 aatatctaaa taaatgattg ttgacaggga agagtataaa gctttaggcc attacagaaa 112141 ggatcttcat tggctgagag agatccatga gccgggtttt agaagtgcgc ccttaagacc 112201 tttgaagaac gttttttgaa atcagtattc aaaggcggcc gccgccgtta caggctgaag 112261 ttgggagagc agaagtctgc ttttcaaaca gagtggaacc gcgcggttaa agcgtctctg 112321 tcatgtttac atgcagagac gcttttttta ttgggtagag gaaatcagat agagaaacgg 112381 ggggaagcat gtgtttttta gaatgctcaa agaagacatt gatactgtgt tcgatcaaga 112441 tcccgcagca agaagctatt ttgaagtgat tttaacttat tccggtttac atgctatatg 112501 ggcgcatcgg attgcacatg ctttatataa acgaaaattt tatttccttg cacgccttat 112561 atctcaagta agccgatttt ttaccgggat agaaatccac cccggcgcta caatcgggag 112621 aagatttttc atagaccacg gcatgggggt tgtcattggg gagacatgtg aaatcggcaa 112681 taacgtaacc gtttttcagg gggttaccct cgggggaacg ggaaaagaaa agggaaaaag 112741 gcacccaacg attaaagatg acgcattgat agccacaggt gctaaagtgc tcggttctat 112801 tacggtcggt gaaggctcaa agattggcgc tggttcagta gtgctgcatg atgttcctga 112861 tttttcaaca gttgtcggta tccctggacg ggtcgttgta caaaatggca agaaagtaag 112921 acgcgattta aaccatcagg atttgcccga tccagttgct gaccgcttta agtctttgga 112981 acagcagatt ttagagctga aggcagaact tgaagacaga aaagaaagga tcaatcaaaa 113041 atgacaatca cactttataa tacattgact agacagaagg aaacattcgt tcctcttgaa 113101 gagggaaaag tgaaaatgta tgtatgcgga cccacggttt acaattacat tcatatcggg 113161 aacgcgcgtc cggcaatcgt ttacgatacg gttcgaaact atttagagta taaaggctat 113221 gatgtgcagt atgtctctaa cttcacagac gtagacgata aattaattaa agcggcaaat 113281 gaactcggtg aggatgtacc caccatttca gagcgtttta ttaaagcata ctttgaagac 113341 gtaggtgcgc tcggctgccg aaaagccgac cttcatccgc gagtaatgga gaacatggat 113401 gccattatcg aattcgtaga tcagctcgtg aaaaagggct acgcatatga atcagaaggt 113461 gacgtatatt tcaaaaccag agcatttgaa gggtacggaa agctttctca gcaatcaatc 113521 gatgaactaa gatcaggtgc acgcatccgg gtcggcgaga aaaaagaaga tgctcttgat 113581 ttcgcactgt ggaaagcggc aaaagaagga gaaatctctt gggatagccc ttgggggaaa 113641 gggcgtccgg gctggcacat tgaatgctca gcaatggtga aaaagtatct cggtgaccag 113701 attgatatcc atgcgggcgg acaggattta acattccctc accatgaaaa cgaaattgcg 113761 caatctgagg cgctgacagg caaaacgttt gcgaagtact ggcttcataa tggttatatc 113821 aatattgata atgaaaaaat gtcaaaatca ctaggcaact ttgtgcttgt gcatgacatc 113881 attaaacagc atgatccgca gcttttgaga ttctttatgc tatctgttca ttatcgccat 113941 ccgattaact attcagaaga gcttctggag aatacgaaaa gcgcgttcag ccgtttaaaa 114001 acagcgtaca gcaatcttca gcaccgtctg aacagcagta cgaatttaac cgaagatgac 114061 gatcaatggc ttgaaaaggt tgaagaacac cgcaaagcat tcgaagaaga gatggacgat 114121 gattttaata cggcgaatgc catttcagtc ttgtttgact tagcgaaaca cgccaattat 114181 tatcttcaga aagatcatac ggctgatcat gtgattacgg cgtttattga gatgtttgac 114241 cgcattgttt ctgtcctcgg tttttcgttg ggtgagcagg aacttctcga tcaagagatt 114301 gaagacttaa tcgaaaagcg aaatgaagcg cgccggaatc gcgattttgc attgtcagac 114361 cagatccgcg accagctgaa aagcatgaat atcattcttg aagatacggc tcaaggcact 114421 cgctggaaac ggggagaata acagatgctt gaatttgata cgataaaaga ttctaagcag 114481 cttaacggtc ttgcgcttgc ttatataggt gatgccattt ttgaagtgta tgtcaggcat 114541 cacctgctta agcagggctt taccaaacca aatgatcttc ataagaaatc aagccggatt 114601 gtttcagcaa agtcacaggc tgagatccta ttttttctgc agaatcaatc attttttacg 114661 gaagaagagg aagcggtgct gaaaagaggc agaaatgcca agtcagggac aacacctaaa 114721 aatacagatg ttcagacgta ccgctacagt acagcatttg aagcgcttct gggctacctt 114781 tttctagaga aaaaagagga acgacttagt cagctcgtag ccgaagctat acaattcggg 114841 acgtcaggga ggaaaacaaa tgagtcagca acatgattac gtcataggga aaaatgcagt 114901 gatcgagacg ttaaaatctg atcggaagct gtataagctg tggatggcgg aaaacaccgt 114961 aaagggacaa gcacagcaag tgattgagct tgccaaaaag cagggaatca cgattcaata 115021 cgtcccgaga aaaaaactcg atcaaatggt gacaggacag catcagggcg tagtggcaca 115081 ggttgcagcg tatgaatatg cagaactgga cgatttatat aaagcagccg aagaaaaaaa 115141 tgaacagcct ttcttcctca ttctggacga gcttgaagac cctcataatc ttggttccat 115201 tatgaggaca gcagatgcgg tcggcgctca tggcatcgtc attccaaaac ggagagctgt 115261 cgggctgaca acaacagtgg caaaagcttc aacaggagca attgagcaca ttcctgtagc 115321 aagagtcacc aatttggcac ggacgttaga agagatgaaa gagcggggaa tctgggttgt 115381 cggaacggat gcgtccgcgc gtgaggattt ccgtaatatg gacggcaata tgcctttggc 115441 tctagtcatc ggaagtgaag gaaaagggat gggccgcctt gtgaaggaaa agtgcgattt 115501 tctcattaaa ctcccgatgg ccggaaaggt aacttcacta aatgcatctg tcgcggctgg 115561 tcttttgatg tatgaagtct accggaaacg aaaccctgtg ggagaataaa gacccatgga 115621 tatcctgtta gtagacgggt acaacatgat tggagcctgg ccgcagctga aggatttaaa 115681 agcgaacagt tttgaagagg cgagagacgt actgattcag aaaatggcgg aatatcaatc 115741 gtatacagga aacagggtta ttgttgtttt tgacgcgcat ctcgtaaaag ggcttgagaa 115801 aaaacagacc aaccatagag ttgaagtaat ttttacaaaa gaaaatgaga cggctgatga 115861 gcggatagaa aagctcgctc aggctttgaa taatattgcg actcaaattc acgttgcgac 115921 ctctgactat actgagcagt gggcgatttt cggacagggg gcattgcgga aatcggcccg 115981 ggagcttctg agagaggtag aaacgattga aaggcgaata gagagacggg taagaaaaat 116041 cacttccgaa aagccggcgg gtaaaattgc tttatcggaa gaggttttga aaacgtttga 116101 aaagtggagg cggggagact tagattaagt tgacgctttt ttgcccaata ctgtataata 116161 tttctatcta cgtgcgccgg ggggatcgga gtgaatctac agaacaacaa gggaaaattc 116221 aacaaagagc agttttgcca gttggaggac gagcaggtca ttgaaaaggt tcatgttggg 116281 gacagtgatg cgttagatta cttgattacg aagtaccgaa actttgttcg ggcaaaagca 116341 agatcctatt tcttaatagg ggcggacaga gaggatattg ttcaggaagg catgataggc 116401 ctctataagt ctattcgtga cttcaaagag gacaagctta cctcattcaa agcttttgca 116461 gaattatgta ttacccgcca aattattacc gcaataaaga cagctactcg ccagaaacac 116521 attcctttga attcctacgc ctcattagat aaaccgatct ttgatgaaga atcagaccga 116581 acgctgctgg atgtcatttc aggagcgaaa accttaaatc ctgaggaaat gatcattaat 116641 caggaagaat ttgatgatat tgaaatgaaa atgggagaac tattaagtga tttagagaga 116701 aaagtactcg tcttatatct cgacgggaga agttaccaag agatttctga tgaactgaac 116761 cgacatgtga aatcgatcga caatgccctt cagcgtgtga aacgcaagct ggagaagtac 116821 ttggaaattc gcgaaatcag tttgtaatag gaatttatgc tatattgaca gtatttttct 116881 gactatgata tgttactaaa gataagaact aatgtctatt tagaaaaagg tgtaatgaca 116941 tgagaaaaaa gattacgtta gcatgcaaga catgcggaaa ccgtaattat acgacaatga 117001 agagctctgc atcagcggct gagcgattag aagtaaagaa atactgcagt acttgcaatt 117061 cacatacagc tcatcttgaa acaaaatagt ttttgcgctt ttaaattgtg gaggtctttt 117121 acatgcgtat tatgaaattc tttaaagatg ttgggaaaga aatgaaaaag gtaagctggc 117181 ctaaaggaaa agagttaacg cgttatacca ttacggtaat ttcaacagtt atcttttttg 117241 ttatcttttt tgccctcctt gacacaggaa tttctcaatt aattcgttta atagttgaat 117301 aatgatcagc aatacgtgct ataatagatc ataatattac ttgccaaaac ccgttcagcg 117361 ggttttttat tgtggcttaa aatgaaagtt atcataggct tgccgcctat tttttgaagc 117421 gttatggtaa ttcactaaaa ccaaatgcgg ggagggaagg actggacagt cctgaataga 117481 atggaaaaga attggtatgt tgttcacacg tactctggtt atgagaataa agtaaaagcc 117541 aacttggaaa agcgtgttga atcaatgggg atgcaggata aaattttccg tgtagtcgta 117601 cccgaagaag aagaaacgga tatcaaaaac ggcaagaaaa aagtcgtgaa aaagaaagta 117661 ttccctggtt atgtgcttgt tgaaattgta atgacagacg actcttggta tgtcgtccgc 117721 aacacgccgg gcgttactgg attcgtagga tctgccgggt caggttcaaa accgacgccg 117781 cttcttccgg gggaagcaga aaccattctg aagagaatgg gcatggatga acgaaaaact 117841 gatattgact ttgaactgaa agagacagtg aaagtaatag acggaccttt tgctaacttt 117901 acaggatcaa ttgaagagat tgattatgat aaaagcaagg tcaaagtttt cgttaatatg 117961 tttggccgtg aaacgccggt tgagctggaa tttacccaaa tcgataaatt gtaatgtgaa 118021 aaaacttgaa attgctatat ataaatgata atatagcaaa ggtacgtctt ggacttatcc 118081 aaggcaacta gcatgatatt tcgtcattca tataaagaat gaaaccttga gtgggagggt 118141 ttaccctatt accacatcac ggacttaagg aggtgtgtct cgtggctaaa aaagtagtta 118201 aagttgtaaa attgcaaatt cctgctggaa aagctaaccc agcaccacca gttggacctg 118261 cacttggtca agccggtgtt aacatcatgg gattctgtaa ggagtttaac gctcgtacag 118321 ctgaccaagc tggtttaatc attcctgttg aaatttcggt ttacgaagac cgttcattta 118381 catttattac aaaaactcca cctgctgcag tattgcttaa aaaagcagct ggaattgagt 118441 ctggttctgg tgaaccaaac cgtaataaag tggcaaccgt taagcgcgat aaagtacgcg 118501 aaatcgctga aacgaaaatg cctgacttaa acgcagcaga cgttgaagcg gcaatgcgca 118561 tggttgaagg tactgcccgc agtatgggta ttgtaatcga ggattaattt gtttcttgtc 118621 gggttgcgag ttttaacaag ttcgcaaccc ttattcgtgg gaggttattc cgctataacc 118681 acataaggag gaaattttaa aatggctaaa aaaggtaaaa agtacgttga agctgctaag 118741 cttgtagacc gttctaaagc ttacgacgtc tctgaagcag tagctctcgt taaaaaaaca 118801 aacacagcta aattcgacgc tacagttgaa gtggctttcc gtttaggggt tgaccctcgt 118861 aaaaacgacc agcaaatccg tggagcagtt gtgcttccaa acggaactgg taaaactcag 118921 cgcgttctcg ttttcgcaaa aggcgaaaaa gcgaaagaag ctgaagctgc tggtgcagat 118981 ttcgtaggcg atactgacta catcaacaaa attcaacaag gctggttcga tttcgatgtt 119041 atcgtagcta cacctgacat gatgggtgaa gttggtaaaa tcggtcgtgt acttggacca 119101 aaaggtttaa tgccgaaccc taaaactggt acagttactt tcgaagttga aaaagctatc 119161 ggcgaaatca aagctggtaa agttgaatac cgcgttgata aagctggaaa cattcatgtt 119221 cctatcggta aagtttcttt cgaggatgaa aaacttgttg agaacttcac aacaatgtac 119281 gatacaatcc ttaaagctaa acctgctgca gctaaaggcg tttacgtgaa aaacgttgct 119341 gtaacttcta ctatgggacc tggtgtcaaa gtagactctt caacttttaa cgtaaaataa 119401 tattgacatg acatcaacat tctgatatta ttcaaaatgt tgtaaaatag aatatcattt 119461 ataccgtaga cagtaggggc ctaaccgctt aattatccta ccgaggtgta tattatcaca 119521 gctattacgt tacgtatgct tgtatataca gcctccatgt ctcatggagg ctttttatat 119581 ggaatccgtc gtctcagtcg tgatcaccta acggtataag tgttacacaa gaatctacag 119641 gaggtgtaac catgagcagc gcaattgaaa caaaaaaagt tgttgttgaa gaaattgctt 119701 ctaaactgaa agaaagtaaa tcaacgatca tcgttgacta tcgcggactt aacgtttctg 119761 aagtaactga acttcgtaaa cagcttcgcg aagctaacgt tgagttcaaa gtttacaaaa 119821 atacgatgac tcgccgtgcg gttgaacaag ctgagcttaa tggtttgaat gatttcttaa 119881 ctggaccgaa cgcgatcgca ttcagcactg aagatgttgt cgctccggct aaagttctta 119941 atgacttcgc taaaaatcac gaagctcttg aaatcaaagc tggcgttatc gaaggtaaag 120001 tttctactgt tgaagaagtg aaagctcttg ctgaacttcc atcacgcgaa ggcttgcttt 120061 ctatgttgct tagcgtactt caagctccag ttcgcaacct tgctcttgct gcaaaagctg 120121 tggcagaaca aaaggaagaa caaggcgctt aatctaatca gtttttcata aattaaaaca 120181 aaatggagga attacaaatg gctttaaata tcgaagaaat cattgcttcc gttaaagaag 120241 caactgtact tgaattgaac gacctagtaa aagcaatcga agaagaattt ggcgtaactg 120301 ctgctgctcc tgtagctgta gctggcggag ctgctgctgg cggagctgct gaagagcaaa 120361 gcgaattcga tcttatcctt gctggtgcag gatctcaaaa aatcaaagtt atcaaagttg 120421 tacgtgaaat cactggtctt ggcttgaaag aagctaaaga gcttgttgac aacactccaa 120481 aaccacttaa agaaggtatt gctaaagaag aagctgaaga gcttaaagct aaacttgaag 120541 aagttggcgc ttctgtagaa gttaagtaat cttcacttac ctgtagggga agctcgcttt 120601 tatgaggcga gctttttctt tgccattctt taagccatga aaaaaggagg ttctaataat 120661 gagtgagcac tattattcag aaaaaccttc agtaaaaagc aacaagcaaa cctggtcttt 120721 taggcttcgg aataaagatt tcacgtttac cagcgacagc ggggtttttt ctaaaaaaga 120781 agttgatttc ggctcccgcc tgctgattga ttcttttgaa gagcctgagg ttgagggcgg 120841 cattttagat gtaggctgcg gatacggccc gattggttta tcgctcgcca gcgactttaa 120901 agaccggacc atccacatga ttgacgttaa tgagagagcc gtagaactat caaatgaaaa 120961 tgcggaacag aacggaataa caaacgttaa gatttatcaa agcgatttgt tttcaaacgt 121021 tgattctgct caaacatttg cttctattct tacaaatccc ccaatccgag ccggaaaaaa 121081 agttgtccat gctatctttg agaaaagcgc tgaacactta aaagcttcag gtgaattgtg 121141 gatcgtcata cagaaaaagc aaggcgcgcc ttctgccatt gaaaagctcg aggaactgtt 121201 cgatgaagtt tccgtcgttc aaaaaaagaa aggctattat atcataaaag caaaaaaagt 121261 ttgactcggt attttaacta tgttaatatt gtaaaatgcc aatgtatata ttttgcttga 121321 tatgatgaat tgtcaatatc tatgtataaa ttatacaagt atggaaatgc taataaaatc 121381 ggtatttgtt tttggatgtg gttttcttaa ttagaaaccc ttttttcttt tgtcttgtaa 121441 aagtattttc tttctttgga agaaatgctt attacacata taatacgcat gatttgaggg 121501 gtgaatcagt tgacaggtca actagttcag tatggacgac accgccagcg cagaagctat 121561 gctcgcatta gcgaagtgtt agaattacca aatctcattg aaattcaaac ctcttcttat 121621 cagtggtttc ttgatgaggg tcttagagag atgtttcaag acatatcacc aattgaggat 121681 ttcactggta acctctctct tgagttcatt gattatagtt taggtgagcc taaatatcct 121741 gtagaggaat caaaagaacg tgatgtgact tactcagctc cgctaagagt gaaggttcgt 121801 ttaattaaca aagaaactgg agaggtaaaa gaccaagatg tcttcatggg tgatttccct 121861 attatgacag atacaggtac ttttatcatt aacggtgcgg aacgtgttat cgtttcccag 121921 cttgttcggt ctccaagtgt atatttcagt ggtaaagtag acaaaaacgg taaaaaaggt 121981 tttaccgcaa ctgtcattcc aaaccgtggc gcatggttag aatacgaaac tgatgcgaaa 122041 gatgttgttt atgtccgcat tgatcgcaca cgtaagttgc cggttacggt tcttttgcgt 122101 gctctcggct tcggctccga tcaagagatt cttgatctca taggagaaaa cgaatacctg 122161 cgaaatacgc ttgataaaga taacacagaa aacagcgaca aagcgttgct ggaaatttac 122221 gagcgtctcc gtcctggaga gccgcctaca gtagaaaatg cgaaaagctt gcttgattct 122281 cgtttctttg atccgaaacg atacgatctt gccaatgtag gacgctataa aattaataaa 122341 aaacttcata ttaagaatcg cctcttcaat cagagacttg ctgaaacgct tgttgatcct 122401 gaaacaggag aaatccttgc tgaaaaaggc cagattcttg atagaagaac gcttgataaa 122461 gtactgccat acttagaaaa cggaatcggt tttagaaagc tgtatccgaa tggcggcgtt 122521 gttgaagatg aagtgactct tcaatcaatt aaaatctttg ctccgactga tcaagaagga 122581 gaacaggtta tcaatgtaat cggcaatgct tacatcgaag aagagattaa aaacatcacg 122641 cctgctgata ttatttcttc aatcagctac ttcttcaacc tgctgcacgg agtaggcgac 122701 acagatgata tcgatcatct tggaaaccgc cgtttacgtt ctgtaggcga gcttctccag 122761 aaccaattcc gtatcggttt aagccgtatg gagcgtgtgg ttcgtgagag aatgtcaatt 122821 caagatacga atacaattac gcctcagcag ctgatcaata ttcgtcctgt tattgcgtcc 122881 attaaagagt tctttggaag ctcacagctt tctcaattca tggatcagac gaacccgctt 122941 gctgaattaa cgcacaagcg tcgtctgtca gcattaggac cgggcggatt gacacgtgag 123001 cgtgccggaa tggaagtgcg tgacgttcac tactcccact atggccgtat gtgtccgatt 123061 gaaacgcctg agggcccgaa catcggtttg atcaactcac tatcatctta tgcaaaagta 123121 aaccgttttg gctttattga aacgccatat cgccgcgttg accctgaaac agggaaggta 123181 acgggcagaa tcgattactt aactgctgat gaagaggata actatgttgt cgctcaagcg 123241 aatgctcgtc ttgatgacga aggcgccttt attgatgaca gcatcgtagc tcgtttccgc 123301 ggggagaaca ccgttgtttc cagaaatcgt gtagactaca tggatgtatc gcctaagcag 123361 gttgtatctg ctgcgacagc atgtatcccg ttcttagaaa acgatgactc caaccgtgcc 123421 ctcatgggag cgaacatgca gcgtcaggct gtgcctttga tgcagccgga agcgccattt 123481 gttggaactg gtatggaata cgtatcagga aaagactctg gtgccgctgt tatttgtaaa 123541 caccctggta tcgttgaacg cgtagaagcc aaaaacgttt gggttcgccg ttatgaagaa 123601 gtagacggtc aaaaagtaaa aggaaacctg gataaataca gcctgctgaa atttgtccgc 123661 tctaaccaag gtacgtgcta caaccagcgt ccgatcgtaa gtgtcggcga tgaagtggta 123721 aaaggagaaa tccttgctga cggtccttct atggagcttg gtgaacttgc acttggccgt 123781 aacgtaatgg tcggcttcat gacgtgggat ggctacaact atgaggatgc catcatcatg 123841 agtgaacgcc tagtgaagga tgatgtttat acatctatcc acattgaaga atacgaatca 123901 gaagcacgtg atacgaaact tggacctgaa gaaatcactc gcgatattcc aaacgtcggt 123961 gaagatgcgc ttcgcaatct tgatgaccgc ggaatcatcc gtattggggc agaagtaaaa 124021 gacggagatc ttcttgttgg taaagtaacg cctaaaggcg taactgaact gactgccgaa 124081 gaacgccttc ttcacgccat ctttggcgag aaagcccgcg aggttcgtga tacttctctt 124141 cgtgtgcctc atggcggcgg cggaattatc catgacgtta aagtcttcaa ccgtgaagac 124201 ggagacgaac ttcctccagg tgttaaccag ttagtacgcg tatatatcgt tcagaaacgt 124261 aagatttctg aaggggataa aatggccggt cgtcacggta acaaaggtgt tatctctaag 124321 attcttcctg aagaggatat gccttacctt cctgacggca caccaattga tatcatgctt 124381 aacccgctgg gcgtaccatc acgtatgaac atcgggcagg tattggaact tcacatgggt 124441 atggccgctc gttaccttgg cattcacatt gcatctcctg tatttgacgg agcgcgagaa 124501 gaggatgtct gggaaacact tgaagaagcc ggcatgtctc gtgacgccaa aacagtgctt 124561 tacgacggac gtactggaga gccgtttgat aaccgtgtat ctgtcggtat catgtacatg 124621 atcaaactgg ctcacatggt tgacgataaa cttcatgcac gctctacagg cccttactca 124681 cttgttacgc agcagcctct tggcggtaaa gcgcaatttg gcggacagcg ttttggtgag 124741 atggaggttt gggcacttga agcttacggt gcggcttaca ctcttcaaga aattctgact 124801 gttaagtctg atgacgtggt tggacgtgtg aaaacatacg aagccatcgt taaaggcgac 124861 aatgttcctg aaccaggtgt tccggaatca ttcaaagtat taatcaaaga acttcaaagc 124921 ttaggtatgg atgtcaaaat cctttctggt gatgaagaag aaatagaaat gagagattta 124981 gaagacgaag aagatgcgaa acaagctgac ggcctggcat tatcaggtga tgaagagccg 125041 gaagaaacag catctgcaga cgttgaacgc gatgtagtaa caaaagaata atctctagtt 125101 ataaaggcaa gtgacatcgg ttaatccgaa gataaaaagg gaggtaggcc ccttgctaga 125161 tgtgaacaat tttgagtata tgaacatcgg tcttgcttca ccagataaaa tccgttcatg 125221 gtcttttggt gaagtgaaaa agcctgaaac gataaactat cgtacgttaa aacctgaaaa 125281 ggacggtcta ttctgcgaac gcattttcgg accgactaag gactgggaat gtcattgcgg 125341 gaagtacaag cgagttcgtt ataaaggcgt agtttgtgac cgctgcggag tcgaagtaac 125401 acgggctaaa gtccgtcgtg agagaatggg gcacattgaa ctggctgccc cagtttccca 125461 catttggtat ttcaaaggta ttccaagccg tatgggtctt gtgctggata tgtcacctcg 125521 tgctttagaa gaagtcattt actttgcttc ttacgttgta actgatccgg cgaatacacc 125581 gcttgaaaag aaacagcttc tgtctgagaa agaataccgt gcttatcttg ataaatacgg 125641 taataaattc caagcatcta tgggtgctga agcaattcat aaacttcttc aagatatcga 125701 tcttgtaaaa gaagttgata tgttaaaaga agagctgaaa acttcacaag gacaacgccg 125761 tactcgtgcg atcaaacgtc ttgaagtttt agaagccttc cgtaactcag gaaacaagcc 125821 ttcttggatg atccttgatg tgcttcctgt tattcctccg gagcttagac cgatggttca 125881 gctagatggc ggacgttttg cgacttctga tttgaatgac ctttatcgtc gtgtcatcaa 125941 ccgtaacaat cgtttgaaac gccttttgga ccttggtgcg cctagcatca tcgttcaaaa 126001 cgaaaagcgt atgcttcaag aggctgtcga tgccctaatt gacaacggcc gccgcggacg 126061 ccctgtaaca ggtcctggaa acagaccgtt aaaatctctt tctcacatgc tgaaagggaa 126121 gcaaggccgt ttccgtcaaa accttcttgg taaacgtgtc gattactccg gacgttctgt 126181 aatcgttgtt ggtcctcatt tgaaaatgta ccaatgcgga ttaccgaagg aaatggcact 126241 tgaacttttc aaacctttcg ttatgaaaga acttgttgaa aaaggtcttg ctcacaacat 126301 taagagtgcg aaacgcaaaa ttgagcgcgt acagcctgaa gtttgggatg tactagaatc 126361 agttattaag gagcatccgg tactgctgaa ccgtgcccct acacttcaca gattaggtat 126421 ccaggcgttt gaaccaacgc ttgttgaagg acgcgcaatc cgtcttcacc cgctcgtatg 126481 tacagcttac aacgctgact ttgacggtga ccaaatggcg gttcacgtac cattatctgc 126541 tgaagcacaa gctgaagcac gcatcttgat gcttgctgct caaaacatct tgaaccctaa 126601 agatggtaaa ccggttgtaa caccgtctca ggatatggta ctaggtaact attacctgac 126661 acttgagcgt gccggtgctg tcggtgaagg tatggtcttc aagaatacag acgaagcgct 126721 tcttgcttat caaaacggat atgttcacct tcatacgaga gtagctgttg cagctaactc 126781 acttaagaat gtgacattta ccgaagaaca gcgctcaaaa ttgttaatta caactgtcgg 126841 taagcttgtc ttcaatgaaa ttcttccgga atcattccct tacatgaatg aaccaacgaa 126901 gagcaacatt gaagagaaaa cacctgaccg tttcttctta gaaaaaggtg ctgatgttaa 126961 agctgttatc gcacagcagc caatcaatgc gccgtttaaa aaaggcattc tgggtaaaat 127021 catcgcggaa atctttaaac gattccatat tacggaaacg tctaaaatgc ttgaccgcat 127081 gaaaaaccta ggtttcaaat attcaactaa agctggtatt acagttgggg tttctgacat 127141 cgtcgtactc gatgataaac aagaaattct tgaggaagcg caaagcaaag ttgacaacgt 127201 tatgaagcaa ttccgccgcg gtcttatcac tgaagaagaa cgctatgaga gagtcatctc 127261 tatctggagt gctgcaaaag acgttatcca aggcaaactg atgaaatcac ttgatgaact 127321 caacccgatc tacatgatga gtgactctgg tgcccgtggt aacgcatcta actttacgca 127381 gcttgccgga atgcgcggcc tgatggccaa cccggctgga cgtatcattg agttgccgat 127441 caaatcaagt ttccgtgaag gtctgacagt attggagtac tttatctcca cacacggtgc 127501 gcgtaaaggt cttgccgata ccgctcttaa aactgctgac tcaggttacc ttacacgccg 127561 tctcgttgac gttgctcagg atgttatcat ccgtgaaact gattgcggaa ctgaccgagg 127621 cattcttgct aagcctctta aagaaggaac tgaaacaatt gagcgcttag aagaacgctt 127681 aatcggacgt tttgcaagaa aacaagtgaa gcaccctgaa acaggtgaag tgcttgtgaa 127741 tgaaaacgaa ctgatcgatg aagataaagc actggagatt gtcgaagccg gcattgaaga 127801 agtgtggatc cgttctgcct tcacatgtaa tacgcctcat ggtgtatgta aacgatgcta 127861 tggccgaaat cttgcaactg gctccgatgt tgaagtcggt gaagctgtcg gaatcattgc 127921 tgcccaatca atcggtgagc ctggtacaca gttaacaatg cgtacattcc atacaggcgg 127981 ggttgccgga gacgatatca cacagggtct tccgcgtatc caagagcttt tcgaagcgcg 128041 taatccgaaa ggtcaggcaa caattacaga aatcgacggt acagtcgttg agatcaatga 128101 agttcgtgat aagcaacagg aaattgtggt tcaaggcgca gtggaaacac gttcttatac 128161 ggcaccttac aactcccgcc tgaaagtagc ggaaggagat aaaattactc gaggccaagt 128221 actgacagaa ggttcaatcg atccgaaaga acttcttaaa gtgactgacc tgacgactgt 128281 tcaagagtat cttctccatg aggttcaaaa ggtttaccgt atgcagggtg ttgaaatcgg 128341 tgataaacac gtagaagtaa tggttcgcca gatgcttcgc aaagtacgcg tgattgatgc 128401 cggtgacact gatgtgcttc caggtacatt gcttgatatt caccaattta ctgaagcgaa 128461 caaaaaggta ttgcttgaag gcaaccgacc agctacaggc cgtcctgtct tactcggtat 128521 tacaaaagca tctcttgaaa ctgattcatt cttatctgct gcttccttcc aggaaacaac 128581 acgtgtcctt acagatgcag cgatcaaagg taagcgtgac gagcttctcg gcttgaaaga 128641 gaatgttatc atcggtaagc ttgttccagc aggtacagga atgatgaaat accgtaaagt 128701 aaaaccagta tcaaatgttc agccgactga cgatatggtc ccggttgaat aactgattta 128761 actctgctga aagactgcaa aaacagtctt tcagcagata tatttatgaa aaagtcactc 128821 tatgagaaga acgaatctaa aaaatgtcat accttgttga cattcgtctc ctagaatgat 128881 aatataacca aggtgctcga aataaacctg ttactttgga ggatatgttt atgtcttatg 128941 ataaagtatc acaggccaaa tcaattatta ttggtacgaa gcaaacagtg aaagctctaa 129001 agcgaggttc agtaaaggaa gtagtcgttg caaaagacgc agatccgata ctcacgtcaa 129061 gtgttgtttc acttgctgaa gatcaaggta tctctgtctc aatggttgaa tccatgaaaa 129121 agctcggcaa agcctgcgga attgaggtag gagcagccgc tgttgccatt attttataac 129181 gtacttttgt ttttgcgtaa gattccatct tgtgtaaaga cattgttttt tgccttttga 129241 tgaaccacct gggtatgtgg gttataaaac gtaatgaagg gaggaaaaat tcatgcctac 129301 aattaatcag ctaattcgca aaggacgcgt gagtaaagta gaaaactcaa agtctcctgc 129361 acttaacaaa ggatacaaca gctttaaaaa agagcacact aacgtatctt ctccacaaaa 129421 acgcggggta tgtactcgtg ttggtacaat gacaccgaaa aaaccgaact cagcacttcg 129481 taaatatgct cgtgttcgtt tgactaacgg aatcgaggtt actgcttaca ttcctggtat 129541 cggtcacaac ctgcaagagc acagtgttgt acttatccgc ggcggacgtg taaaagactt 129601 accaggggta cgttaccaca tcgttcgtgg tgcgcttgat actgctggag ttgaaaaccg 129661 tgcacaaggc cgttctaaat acggtacgaa aaaacctaaa gcaaaataat atacgaaaat 129721 acgcataatt gatgaaggga ggatattcag atgccacgta aaggtcctgt agcaaaaaga 129781 gatgttttac ctgatccgat ttacaactct aagcttgtat ctcgtttaat caacaaaatg 129841 atgatcgatg gtaaaaaagg taagtctcaa acgatcctat acaagtcatt cgatatcatt 129901 aaagaacgta ctggcaatga tgcaatggag gttttcgaac aagcattgaa aaacatcatg 129961 cctgtacttg aagtaaaagc acgccgtgta ggtggtgcga actaccaagt tcctgtagaa 130021 gttcgtcctg aacgtcgtac gactcttgga cttcgctggt tagttaacta cgctcgtctt 130081 cgtggagaaa aaacgatgga agagcgttta gctaacgaaa tccttgacgc agctaacaac 130141 actggtgctg ctgttaagaa acgtgaagac actcataaga tggctgaagc aaacaaagca 130201 tttgctcact atcgctggta ggatttatag attaacaaaa cacaatttcc taataaggaa 130261 ggagaaatta cccaatggca agagagttct ccttagaaaa aactcgtaat atcggtatca 130321 tggctcacat cgatgccggt aaaacgacta ctacagaacg tatcttgttc tatactggtc 130381 gtatccacaa aattggtgaa actcatgaag gagcttcaca aatggactgg atggagcagg 130441 aacaagaacg tggtatcaca atcacttccg ctgcgactac tgcacagtgg aaaggatacc 130501 gcgtaaacat catcgatact ccaggacacg tagacttcac agttgaagtt gaacgttctc 130561 ttcgtgtact tgatggtgct gttgctgtac ttgacgcgca atcaggcgtt gagcctcaaa 130621 cagaaactgt ttggcgtcag gcaacaactt atggagtacc gcgtatcgtt tttgttaaca 130681 aaatggacaa aatcggtgca gacttccttt actctgtagg aactttaaga gaccgtcttc 130741 aagcaaacgc tcatgcaatt caattgccga tcggtgctga agataacttc gaaggtatca 130801 ttgaccttgt agaaaacgtt gcgtatttct acgaagatga cctcggaact cgttctgatg 130861 caaaagaaat ccctgaagag tacaaagagc aagctgaaga gcttcgcaac agccttattg 130921 aagctgtatg tgagcttgat gaagagctta tggataagta ccttgagggt gaagaaatca 130981 caattgacga gttaaaagca ggaattcgta aaggtacatt aaatgttgaa ttctaccctg 131041 ttcttgttgg ttctgccttc aaaaacaaag gtgttcaact agtacttgat gctgttcttg 131101 actaccttcc tgcaccaact gacgttgctg caatcaaagg tacacgtcct gatacaaatg 131161 aagagattga gcgtcattct tctgacgaag agccattctc tgcattagca tttaaagtta 131221 tgactgaccc ttacgttggt aagttgacgt tcttccgtgt gtactctgga acacttgatt 131281 ctggttcata cgtgaaaaac tctactaaag gcaaacgtga gcgtgttgga cgtattcttc 131341 aaatgcacgc taacagccgt gaagaaatct ctactgtata cgcaggggat atcgcagctg 131401 ctgtaggtct aaaagataca actactggag atactctatg tgatgagaag gatcttgtta 131461 tccttgagtc aatggaattc ccagaaccag ttatcgacgt tgctattgag cctaaatcaa 131521 aagctgacca agataaaatg ggtatcgctt tagcgaaact tgctgaagaa gatcctacat 131581 tccgtactca aacaaaccca gaaactggcc aaacgatcat ctctggtatg ggtgaacttc 131641 accttgatat cattgttgac cgtatgaaac gcgaatttaa agtagaagcc aatgttggtg 131701 ctcctcaagt tgcgtaccgt gaaacattcc gtaccggtgc aaaagttgaa ggtaaattcg 131761 tacgtcagtc tggtggacgc ggtcagttcg gacacgtttg gatcgaattc gaaccaaacg 131821 aagaaggcgc tggctttgaa tttgaaaatg cgattgtcgg tggggtcgtt cctcgtgaat 131881 acatcccagc tgttcaagca ggtctggaag atgcactcga aaatggtgta ctagcaggct 131941 tcccgcttat cgacattaaa gctaaacttt tcgacggttc ttaccatgat gttgactcaa 132001 acgaaatggc atttaaagtc gctgcttcta tggcattgaa aaatgcagtc agcaaatgta 132061 acccagttct tcttgaacca atcatgaaag tggaagtggt tattccagaa gaatatatgg 132121 gagatatcat gggtgatatc acttcacgtc gcggacgcgt agaaggtatg gaagcacgcg 132181 gtaacgctca agttgttcgt gctatggttc ctcttgctga aatgttcggt tacgctactg 132241 cacttcgttc taatacgcaa ggtcgcggta cgttcactat gcacatggat cactacgaag 132301 aagtgccgaa gagcgtcgca gaagaaatta tcaaaaaaaa taaaggcgaa taattgattt 132361 tgccgcttaa ctcaagtata actactattg taagatgagg aagtgaaagc tttctttcac 132421 ttcctatcac tctatacatt actaattaaa agctcttaag gaggatttta gaatggctaa 132481 agaaaaattc gaccgttcca aatcacatgc caatattggt acaattggac acgttgacca 132541 tggtaaaaca actttaactg ctgctatcac aacagtactt cataagaaat ctggtaaagg 132601 tacagctatg gcgtacgatc aaattgatgg tgctccagaa gaacgcgagc gcggtatcac 132661 aatctctact gcacacgttg agtacgaaac tgaaactcgt cactatgcac acgttgactg 132721 cccaggacac gctgactatg ttaaaaacat gatcactggt gctgcgcaaa tggacggagc 132781 tatccttgta gtatctgctg ctgatggccc aatgccacaa actcgtgagc acatccttct 132841 ttctaaaaac gttggtgtac catacatcgt tgtattctta aacaaatgcg acatggtaga 132901 cgacgaagag cttcttgaac tagttgaaat ggaagttcgc gatcttctta gcgaatacga 132961 cttccctggt gatgatgtac cagttgttaa aggttctgct cttaaagctc ttgaaggaga 133021 cgctgagtgg gaagctaaaa tcttcgaact tatggatgcg gttgatgagt acatcccaac 133081 tccagaacgc gacactgaaa aaccattcat gatgccagtt gaggacgtat tctcaatcac 133141 tggtcgtggt acagttgcta ctggccgtgt agaacgcgga caagttaaag tcggtgacga 133201 agttgaaatc atcggtcttc aagaagagaa caagaaaaca actgttacag gtgttgaaat 133261 gttccgtaag cttcttgatt acgctgaagc tggtgacaac attggtgccc ttcttcgcgg 133321 tgtatctcgt gaagaaatcc aacgtggtca agtacttgct aaaccaggta caatcactcc 133381 acacagcaaa ttcaaagctg aagtttacgt tctttctaaa gaagagggtg gacgtcatac 133441 tccattcttc tctaactacc gtcctcagtt ctacttccgt acaactgacg taactggtat 133501 catccatctt ccagaaggcg tagaaatggt tatgcctgga gataacactg aaatgaacgt 133561 tgaacttatt tctacaatcg ctatcgaaga aggaactcgt ttctctattc gtgaaggcgg 133621 acgtactgtt ggttcaggcg ttgtttctac aatcactgag taatagtatg gttttaaacg 133681 agacccctgt gggtctcgtt ttttgtttgc ttatcttttt cttgtataat aggatctatc 133741 atattcgagg ggttaatatt tatgattcct gaaaagaaat caatcgcaat catgaaagaa 133801 ctaagcattg gaaatacaaa gcaaatgctg atgattaatg gagttgacgt gaaaaatcca 133861 ttgctgcttt ttttacatgg cgggccggga acgccgcaaa tcggatatgt tagacattat 133921 caaaaagagc tggaacagta ttttacagta gttcattggg atcagagagg atcggggctt 133981 tcttattcta agcgaatttc gcatcactct atgacaataa atcacttcat taaagataca 134041 atccaagtca ctcaatggct tttagctcat ttttcaaaat caaaacttta cctagccggt 134101 cattcttggg gatcaatact ggcgcttcat gtgctgcagc agcgtcctga tttattttac 134161 acgtattatg gaatcagcca ggttgttaac ccgcaagatg aagaatcaac tgcttatcaa 134221 catattcgtg aaatttccga atcaaaaaaa gccagcatat tatctttcct tacacgtttc 134281 attggtgctc cgccttggaa gcaggatatc cagcacctta tctatcggtt ttgtgttgag 134341 ctaaccaggg gaggattcac tcaccgtcat cgtcaatctc tcgctgtatt atttcaaatg 134401 cttactggca atgagtatgg agtgcggaac atgcacagct tccttaatgg attgcgcttc 134461 agtaaaaaac atttaactga tgagttgtac cggtttaatg cttttacatc agttccttct 134521 attaaagtac cgtgtgtttt catttcaggg aaacatgact taattgttcc tgcagaaata 134581 tcgaaacagt attatcaaga acttgaggca cctgaaaagc gctggtttca atttgagaat 134641 tcagctcaca ccccgcatat tgaggagcca tcattattcg cgaacacatt aagtcggcat 134701 gcacgacacc atttatgata gatccttgat aaataagaaa aacccctgta taataaaaaa 134761 agtgtgcaaa tcatgcatat tttaaataag tcttgcaaca tgcgcctatt ttctgtataa 134821 tggtgtatgt tggtctttga ctgcgatgaa gtgagaggtt gctgacacac ccggccgctt 134881 tgccatggca aggtgttcag gtttttctca cggagaactg tctaacgtga tgtaggcgaa 134941 aaggagggaa aataatggca aaacaaaaaa ttcgtattcg tttgaaagca tatgatcata 135001 gaatccttga tcaatctgca gagaagattg ttgaaacggc aaaacgttct ggtgccagcg 135061 tatctggtcc gattccgttg ccaactgaaa aatcagttta cacaatcctt cgtgcggtgc 135121 acaaatacaa agattctcgt gagcaatttg aaatgcgtac acataaacgt ttaatcgaca 135181 ttgtgaaccc aacaccacaa actgttgatg ctcttatgcg attagactta ccatctggtg 135241 tcgatatcga aattaaactt taattctaaa atatagaatg atcttaatag gaggtgtgac 135301 gaatgaccaa aggaatctta ggaagaaaaa ttggtatgac gcaagtattc gctgagaatg 135361 gtgatcttat tccggtaact gttatcgagg ctgctccaaa cgttgttctt caaaagaaaa 135421 cagctgaaaa cgacggttac gaagcaatcc agcttggttt tgacgacaag cgtgaaaagc 135481 tttctaacaa acctgaaaaa gggcacgttg caaaagcgga aactgctcct aagcgcttcg 135541 ttaaagaatt acgcggagtg gaaatggatg cgtatgaagt tggtcaggaa gtcaaggttg 135601 aaattttctc tgctggagaa atcgtagatg taacaggagt atctaaaggt aaaggtttcc 135661 aaggtgcgat caagcgccac ggacaatctc gcggacctat gtctcacggt tcacgctacc 135721 accgtcgtcc tggttcaatg ggacctgtag atcctaaccg tgtattcaaa ggtaaattat 135781 tacctggacg tatgggcgga gagcaaatca ctgttcaaaa ccttgaaatc gtaaaagttg 135841 atgcagaacg caatcttctt ttgatcaaag gtaacgtacc tggtgcgaag aaatctttaa 135901 tcactgttaa aagtgctgtt aaatctaaat aattctctta ggaaaggagg aaattgatta 135961 tgccaaaagt agcattatac aaccaaaacg gttctactgc tggtgacatc gaattaaacg 136021 cttctgtatt tggtatcgaa ccaaatgaga gtgttgtatt cgacgctatt cttatgcaaa 136081 gagcttcctt acgtcaagga actcacaaag taaaaaatcg ttctgaagta cgcggcggag 136141 gtcgtaaacc atggcgtcaa aaaggtactg gacgtgcccg tcaaggttca atccgttcac 136201 cgcaatggcg cggaggtggt gtcgtattcg gcccaacacc acgcagctat tcttataaat 136261 tacctaaaaa agttcgccgc ttggcaatca aatcagtatt gtcttctaaa gtgatcgaca 136321 acaacatcat cgttcttgaa gatcttactc ttgatacggc taaaacaaaa gaaatggcag 136381 ctatccttaa aggattatct gttgagaaaa aagctttaat cgtaactgcg gatgcaaacg 136441 aagcagtagc attatctgct cgtaacattc ctggagttac tgttgttgaa gctaacggaa 136501 tcaacgtttt agacgttgtc aaccacgaga agcttctgat tacaaaagca gcggttgaaa 136561 aagtagagga ggtgcttgca taatgaaaga tcctcgtgat gttctaaagc gccccgtcat 136621 tactgaacgt tctgccgatt taatgactga aaaaaaatat acttttgaag ttgatgtaag 136681 agctaacaaa acagaagtga aagacgcggt tgaaagcatc tttggagtga aagttgacaa 136741 agtcaacatc atgaactaca aaggcaaatc aaaacgtgtt ggacgctaca ctggtatgac 136801 tagccgtcgc agaaaagcga tcgtaaaact tactgcagac agcaaagaaa tcgaaatttt 136861 tgaagcttaa ttatctgtaa aaagaaggag ggaaattcaa aatggcgatt aaaaagtata 136921 aaccgacctc taatggacgt cgtggcatga caacttcaga ttttgctgaa atcacgactg 136981 acaagccgga aaaatccttg cttgctcccc ttcacaaaaa aggcggacgt aacaaccaag 137041 gtaaattgac tgtacgtcac caaggtggcg gacataaacg ccaataccgt gttatcgact 137101 tcaaacgcga taaagatggt atacctggac gcgttgctac agttgaatac gatccaaacc 137161 gttcagctaa catcgctcta atcaactatg cagacggaga aaaacgttac attcttgctc 137221 ctaaaggaat tcaagtaggt actgaaatca tgtcaggtcc tgaagctgac attaaagtag 137281 gtaatgcact tccacttatc aacatccctg ttggtacagt tgtgcataac attgaattaa 137341 aacctggtaa aggcggacag cttgtacgtt cagctggtac atctgctcag gttcttggta 137401 aagaaggtaa atacgttctt gtacgtctta actctggtga agttcgcatg atcctttctg 137461 cttgccgtgc ttctatcggt caagtaggta acgaacagca cgaacttatc aacattggta 137521 aagctggacg ttctcgctgg aaaggcatcc gtcctacagt tcgtggttct gtaatgaacc 137581 ctaacgatca cccacacggt ggtggtgaag gacgtgcgcc aatcggacgt aaatcaccaa 137641 tgtctccatg gggcaaacca actcttggat tcaagactcg taagaaaaag aacaaatccg 137701 ataaatttat cgtacgtcgt cgtaaaaata aataacgggg ttgtctacgg ttcttttcgg 137761 accgtagtgc aatcacgaag ggaggttcca aaatggctcg cagcttaaaa aaaggaccat 137821 ttgtcgatgg acacttgatg actaaaatcg agaaattaaa tgaaacagac aagaaacaag 137881 tcgtaaaaac ttggtctcgt cgttctacta ttttcccaca gtttattggt cacacaatcg 137941 cagtctatga cggacgtaaa cacgtgcctg tattcatctc tgaagatatg gtagggcaca 138001 agttgggtga attcgctcca actcgtacgt acaaaggtca tgctagtgat gacaaaaaaa 138061 caagacgcta agagaggagg cttttaaatg caagctaaag ctgttgcaag aacagtccgt 138121 attgctcctc gtaaagcacg tctagtaatg gacctgattc gaggcaagca agtaggtgag 138181 gcagtatcaa tcttgaacct tacaccaaga gctgcttctc caattatcga gaaagtatta 138241 aaatccgcta ttgcaaatgc tgagcataac tatgaaatgg acgctaacaa cctggttatt 138301 tctcaagcat tcgttgacga aggccctacg ttaaaaagat tccgcccacg tgctatggga 138361 cgtgcgagcc aaatcaacaa acgtacgagc cacattacaa tcgttgtatc agaaaagaag 138421 gagggataag tagtgggtca aaaggtaaat ccagtcggtc ttcgtatcgg agtcattcgt 138481 gattgggaat ctaagtggta cgctggtaaa gattacgctg acttcctgca cgaagattta 138541 aaaattcgtg aatacattag caaacgcctt tctgacgctt ctgtttctaa agtagaaatt 138601 gagcgtgcag caaaccgcgt taacattacg atccacacag ctaagcctgg tatggttatc 138661 ggtaaaggcg gttctgaagt cgaagcactt cgcaaagccc ttaacagcct tactggcaag 138721 cgtgtacaca ttaacattct tgaaatcaaa agagcagatc ttgatgcaca gctagttgct 138781 gacaacatcg ctcgtcaatt agaaaaccgt gtttctttcc gccgtgcgca gaaacaacaa 138841 atccaacgta ctatgcgtgc tggagcacaa ggtgtgaaaa caatggtttc tggtcgtctt 138901 ggcggtgcag atatcgctcg ttctgaatac tacagtgaag gaactgttcc attgcacaca 138961 ttacgtgcgg acattgacta tgcaacatct gaagctgata ctacttacgg taagcttggt 139021 gtaaaagtct ggatctatcg tggagaggtt cttcctacta agaagaaaaa tgaggaagga 139081 ggaaaataat atgttattac caaaacgcgt taaatatcgc agagagcatc gcggaaaaat 139141 gcgtggccgt gcgaaaggcg gtactgaagt acatttcgga gaattcggta tccaagctct 139201 agaagcttct tggattacta accgtcaaat cgaagctgca cgtattgcga tgactcgtta 139261 catgaaacgt ggcggtaaag tttggatcaa aattttccct tctaaacctt acactgctaa 139321 accacttgag gtacgtatgg gatccggtaa aggggctcca gaaggttggg tagctgttgt 139381 aaaaccgggc aaagttttat ttgaaatttc tggtgtgtct gaagaggttg ctcgtgaagc 139441 gcttcgcctt gcatctcaca aattgccaat taaaacgaag ttcgtaaaac gtgaagaaat 139501 tggtggtgaa tcaaatgaaa gctaatgaaa ttcgtgacct taccactgct gaaattgaac 139561 aaaaagtaaa gtctcttaaa gaagaacttt tcaatcttcg ctttcaatta gcgacaggac 139621 aacttgaaaa tactgctcgc attcgtgaag tgcgcaaagc tatcgcgcgc atgaaaactg 139681 tgattcgtga aagagaaatt gctgctaata aataatcact gaggggaggt cgtgagcatg 139741 agcgaacgta accaacgcaa agtttaccaa ggccgtgttg tttctgacaa aatggataaa 139801 accattactg ttgttgttga gacatacaaa aaacatacac tttacggtaa acgcgtaaaa 139861 tactcaaaaa aattcaaagc acatgatgaa aataatcaag ctaaaatcgg tgacatcgtt 139921 aagatcatgg aaactcgtcc attgtctgca actaagcgtt tccgtctagt tgaagttgtc 139981 gaagaagctg ttattatcta ataaagttcg gaattctttt tccgaaggga ggtaacaaat 140041 aatgattcaa caagagactc gtttaaaagt agctgacaac tctggcgcac gtgaagtact 140101 tactattaaa gttcttggtg gttctggacg taaaacagct aacattggtg atgtaattgt 140161 ttgcacggtt aaacaagcaa caccaggagg cgttgtcaaa aaaggtgaag tcgtaaaagc 140221 tgttatcgtt cgcactaaaa gcggagcgcg cagaagtgac ggttcataca tcagcttcga 140281 tgagaatgca tgtgttatca tccgtgacga caagagccca cgcggaactc gtatcttcgg 140341 accagttgct cgtgaattgc gtgaaaacaa ctttatgaaa attgtttctc tagctccaga 140401 agttatctaa ttgaaataaa tgccttactc aaggaggtgc gatcaggatg catgtaaaaa 140461 aaggcgataa agttatggtt atctctggta aagataaagg caaacaagga acaatccttg 140521 ctgctttccc taaaaaggac cgcgttttag ttgaaggtgt taacatggta aagaaacact 140581 ctaaaccaac tcaagctaac cctcaaggcg gtatttctaa tcaagaggcg ccaattcatg 140641 tatcaaacgt tatgccgctc gatcctaaaa caggtgaagt gactcgcgta ggatacaaag 140701 tggaagatgg caaaaaagtt cgtgtagcaa aaaaatctgg gcaagttcta gataaatagt 140761 attaaaagga agggaggtct atctcatgaa ccgccttaaa gaaaagtaca ataaagaaat 140821 tgcacctgct ttaatgacta agttcaacta tgattcagtc atgcaagtgc ctaaaatcga 140881 aaaaatcgta atcaacatgg gtgttggtga cgctgttcaa aacgccaaag caatcgacag 140941 tgctgttgag gaattaacgt ttatcgcagg tcaaaaacct gtcgttactc gtgcgaagaa 141001 atcaattgct ggattccgtc ttcgtgaggg aatgcctatc ggtgcgaaag taactcttcg 141061 cggagagcgc atgtatgatt tccttgataa acttatttct gtatctttac cgcgtgtacg 141121 tgacttccgc ggggtttcta aaaaatcttt cgacggtcgc ggtaactaca cacttggtat 141181 caaagaacag ttaatcttcc ctgaaattga ctacgataaa gtaacaaagg ttcgcggaat 141241 ggacatcgtt atcgtaacaa ctgctaatac tgacgaagaa gctcgtgagc tattaactca 141301 agtaggtatg ccgttccaga aataatcaat gaaagggagg cgaaatcgtg gctaaaaagt 141361 ctatgattgc gaaacaacaa cgtacaccaa agtttaaagt acaagagtac acacgctgtg 141421 aacgctgcgg acgtccgcat tcagtcattc gtaaatttaa actttgccgt atttgtttcc 141481 gtgagcttgc atataaagga caaattcctg gcgtgaaaaa agccagctgg taatccccaa 141541 gaaagggaag gaggtaatta tataatggtt atgacagatc caattgcaga tatgctaact 141601 cgtattcgca atgcaaacat ggtacgtcat gagaagcttg aaattcctgc ttctaaattg 141661 aaaagagaaa ttgctgaaat tttaaagcgt gaaggtttca ttcgtgacgt tgagttcgta 141721 gaagacagca aacaaggtat tatccgcgtt ttcttgaaat acggacaaaa caacgagcgc 141781 gttatcactg gtcttaaaag aatcagcaag cctggtttgc gtgtttatgc taaatctaat 141841 gaagtacccc gcgtacttaa cggtcttgga atcgcgatta tttctacatc acaaggtgtt 141901 ttaacggaca aagaagcccg tgcaaaacaa gctggtggag aagttctagc atacgtttgg 141961 taagaagttt aacatgaatg gaggtgtttg gtatgtctcg tgtaggtaag aagctacttg 142021 agattccttc tgatgttaca gtaacgttaa atgataacaa cactgtagct gtgaaaggac 142081 caaaaggaga attaactcgt acgtttcacc ctgatatgga gattaaagta gaggacaatg 142141 tgcttacagt cgctcgtcct tctgatcaaa aagagcaccg tgccctgcat ggtacgactc 142201 gcagtctgct tggcaacatg gttgaaggtg tatctaaagg atttgaaaga ggtttggaat 142261 tagtcggtgt cggttaccgt gcttctaaat ccggaaataa acttgtttta aacgttggat 142321 actctcatcc tgttgagatc gttcctgaag aaggcatcga aatcgaagtt ccttctcaaa 142381 caaaagtagt tgtaaaaggt acagacaaag aacgcgtagg agctattgct gctaacatcc 142441 gcgctgtacg ttctccagag ccttacaaag gtaaaggaat ccgctacgaa ggtgaagttg 142501 ttcgccgtaa agaaggtaaa tctgctaagt aagatcgctt aaagtgaaga aaggagtgac 142561 ctagatgatt acgaaaacta gcaaaaatgc tgctcgtctt aaaagacacg ctcgtgttcg 142621 cgctaaactt tccggtactg ctgaaagacc gcgcctgaac gttttccgtt ctaacaagca 142681 catttacgct caaatcatcg atgatgtaaa tggtgtaaca cttgctagtg catctactct 142741 cgataaagac ttgaacgttg aaagcactgg agatacttct gctgctacta aagttggaga 142801 attagttgca aaacgcgctg ctgaaaaagg catttctgac gtagtatttg accgtggcgg 142861 atacttatac catggacgtg taaaagcttt ggctgatgcc gctcgtgaag ctggacttaa 142921 attttaataa aagaaggagg gacacatgat tatgcgtcgt attgacccaa gcaaattaga 142981 gttagaagaa cgcttagtta cggttaaccg cgtagcgaaa gttgttaaag gtggtcgtcg 143041 tttccgcttc gcagctctag tcgttgtcgg tgacaaaaac ggacacgtag gattcggtac 143101 tggtaaagca caagaagtac cagaagcgat tcgcaaagct gttgaagatg cgaaaaagaa 143161 tttgattgaa gtaccaatgg ttggaactac aattccacac gaaatcatcg gacgtttcgg 143221 tgcaggtaac atcttgttaa aacctgcttc tgaaggtact ggagttatcg ctggaggccc 143281 tgtacgtgcg gtacttgagc tagctggtgt agctgatatc ctttctaagt ctttaggttc 143341 taacacaccg atcaacatga ttcgtgcaac acttcaaggt ttaagtgaac ttaaacgtgc 143401 tgaagacgtt gcgaagcttc gtggaaaatc tgtagaagaa ctgttaggat aaggagggaa 143461 cattaatggc taaattagaa attaccctca aacgaagtgt aatcggtcgc ccggaagacc 143521 aacgcgttac tgtaagaaca cttggtttaa agaaaacaaa ccaaactgtt gttcatgaag 143581 acaacgctgc gatccgtggt atgattaata aagtatctca tttagtttct gttaaagaac 143641 aataaaaata tttgatcgga taaggaggtg tcctaatgaa acttcatgaa ttaaaacctt 143701 cagaaggttc acgcaaaacg cgtaatcgcg taggtcgtgg tattggttct ggcaacggta 143761 aaacagctgg taaaggtcac aaaggtcaaa acgctcgttc tggcggcggt gtacgccctg 143821 gattcgaggg gggacaaatg cctttattcc aacgtcttcc taaacgtggt ttcactaaca 143881 tcaaccgcaa ggaatacgct gtagtcaacc tagacaaatt gaacggtttt gcagaaggaa 143941 cggaagtcac tcctgaactt cttctagaga ctggtgttat tagcaaactt aatgcaggag 144001 taaagattct tggcaacggt aaattagaga aaaaattaac tgtaaaagcc aataaattct 144061 ctgcttctgc gaaagaagct gttgaagctg ctggcggtac agctgaggtg atctaacttg 144121 tttaaaacaa tctccaactt tatgcgtgtg agtgatatca ggaataaaat catattcact 144181 ttactcatgc ttatcgtctt tcgcataggt gcgtttattc ctgtgcctta cgttaacgct 144241 gaagcgttac aggcacagtc tcaaatgggt gtttttgatc tccttaatac atttggcggc 144301 ggtgcgcttt accaattttc cattttcgca atgggaatta ctccttatat cacggcttcg 144361 atcatcattc agctgcttca gatggatgtg gtaccgaagt ttaccgagtg gtctaagcaa 144421 ggtgaagttg gccgccgtaa attagctcag ttcacaaggt actttacgat tgtgcttggt 144481 ttcatccaag cgttaggtat gtcatatgga ttcaacaatc tggcaaacgg tatgctgatc 144541 gaaaaatccg gtgtatcgac atatcttatc attgctttag tgctcactgg cggaactgcc 144601 tttttaatgt ggcttgggga acaaattact tctcatggag taggcaacgg aatatcgatc 144661 attatcttcg cggggattgt gtctagtatt ccaaaaacaa ttgggcaaat atatgagact 144721 caatttgtcg gcagcaacga tcagttgttt attcatattg tgaaagtcgc acttcttgtg 144781 attgcgattt tagcagttat tgttggagtt attttcattc agcaagccgt acggaaaatt 144841 gcgattcaat atgctaaagg cacaggtcgt tcacctgctg gcggaggtca gtctacacac 144901 cttccattga aagtgaatcc tgcaggggtt attccggtaa tctttgcggt tgcgtttttg 144961 ataacgccgc ggacgatcgc gtcattcttt ggaacaaacg atgtgacaaa gtggattcaa 145021 aacaactttg ataatacgca tccggtgggt atggcgatat atgttgcgtt gattattgcc 145081 tttacgtact tttatgcttt tgtacaggta aaccctgaac aaatggctga taaccttaaa 145141 aaacagggtg gctatatccc gggggttcgt ccagggaaaa tgactcaaga tagaattacg 145201 agcattttgt atcgacttac gtttgtgggt tctatattct tagccgtgat ttccattctt 145261 cctatctttt tcattcaatt cgctggattg cctcaaagtg cacaaattgg cggaacatct 145321 ttgttaattg ttgtcggggt agccttggag acaatgaaac aactagaaag ccagttggtg 145381 aaacgaaact accgtggatt tatgaaaaac tagaggaaat ggatttatcc attccctctt 145441 aataaagaga ggacggggga aatccgaatg aacttagtct taatggggct tcctggtgcc 145501 ggtaaaggca cacagggcga acgaattgtt gaggattatg ggattcctca tatctcaaca 145561 ggagatatgt tccgtgctgc tatgaaagaa gaaacaccac tcggactcga agcaaaatct 145621 tatattgata agggagagct cgtacctgac gaagtcacaa tcggaattgt aaaagagaga 145681 cttggcaaag atgattgtga aagaggtttt cttctggacg gatttccgcg aacagtcgct 145741 caagccgaag ctcttgaaga aattcttgag gaatacggca agccgattga ttatgtcatt 145801 aacattgaag tcgacaaaga tgttctgatg gaacgtctga ctggacgcag aatttgcagt 145861 gtttgcggca caacctatca tttagtcttt aatccgccga aaacgccggg tatttgtgat 145921 aaagacggag gcgaactcta tcaacgggca gatgataatg aggaaacagt ctctaaacgg 145981 cttgaggtaa acatgaagca aactcagcct ttactcgatt tctattcaga gaaaggttat 146041 cttgcaaacg tgaatggcca gcaggacatt caagacgttt atgcagatgt gaaggatctt 146101 cttggaggat taaaaaaatg attatctgta aaaccccacg tgaacttggt atcatgcggg 146161 aagcagggcg aatcgtggct ttaactcatg aagagttaaa aaagcacatt aaaccaggaa 146221 tctcgacaaa agaattggat caaattgccg aacgttttat taagaagcag ggtgcaatcc 146281 catcttttaa ggggtataat gggtttcgcg ggagcatttg cgtatcagtt aatgaagaac 146341 tcgttcacgg catacctggc agcagggtgc tgaaggacgg tgacatcatc agtattgata 146401 tcggtgctaa attaaatggt tatcatggtg actctgcatg gacatatccg gtaggaaaca 146461 tcagcgatga tgacaaaaaa cttctggaag tgacagagga gtctttatat aaaggcttgc 146521 aggaagcaaa accaggtgaa cgtttgtcga atatttccca cgcaatacaa acgtatgtcg 146581 aaaatgagca gttttcagtt gttagggagt atgtcggaca tggtgttggt caagacttgc 146641 atgaggaccc gcaaattcct cattacggtc cgcccaacaa aggaccacgg cttaaacctg 146701 gcatggttct cgctattgaa cctatggtga acgctggcag ccgctacgtg aaaacattgg 146761 ctgataactg gacggttgta acggtagatg ggaaaaagtg tgctcatttt gaacatacga 146821 ttgcgattac ggaaacgggt tttgatatac tgacgagagt ctagatgatg aaaataattc 146881 cgaagacaga tgtttttcaa gcttgatagg gcagaaagct tgggtgaaca ttggcaagac 146941 cgaattcatc ttgcttcttg tcgttggaat tttaaccatc atcaatgtac taacagcaga 147001 cggagaaaag cgtacatttc attctcctaa gaaaaagaat atcaatcatt taacccttta 147061 tgattgcgta tctccggaag ttcagaacag tataaacgaa acagggcgtg tgacaaactt 147121 cttttgaaat ttgtcagaaa gcaagttact gatttgaaga agggagaaca cttgaatggc 147181 gaaagacgat gtaattgaag tggaaggtac tatagtcgaa acactgccaa acgcgatgtt 147241 caaagttgaa cttgaaaatg gccacactgt tttggctcat gtatctggta aaatccgcat 147301 gcacttcatt cgcattttac ctggagacaa agttacggta gaattatctc catatgactt 147361 aactcgtggc aggattacgt accgttacaa ataaagcact ccggaaactg aaggaggttg 147421 gaaacacatg aaagtgagac catcagttaa accaatctgc gaaaaatgta aagttattcg 147481 cagaaaagga aaagtaatgg tgatctgtga aaatccaaag cataaacaaa aacaaggata 147541 atttataagg aggtgcccag agaatggctc gtattgctgg tgtagatatc ccacgtgaca 147601 aacgtgttgt tatttcttta acatacatct tcggaattgg ccgcacaacg gctcagcaag 147661 ttttaaaaga agctggagtt tcagaagata ctcgtgtgcg cgatcttact gaagaagaac 147721 ttggtaaaat ccgtgatatt attgacaaac tgaaagtaga aggtgacctt cgccgtgaag 147781 tttctcttaa tatcaaacgt ctgatcgaaa tcggaagcta ccgcggaatc cgtcatcgca 147841 gaggattacc tgttcgcgga caaaactcta aaaacaacgc gcgtactcgt aaaggtccgc 147901 gtcgtactgt agctaacaag aaaaaataag taagggaggt tcttaaacaa tggctgctgc 147961 tcgtaaatct aacacgcgta aacgtcgcgt gaaaaagaat attgagtctg gaattgctca 148021 tattcgttca actttcaata acacgatcgt tacgatcact gacactcatg gtaatgctat 148081 ttcttggtct agtgccggag ctttaggatt cagaggttct cgtaaatcta ctccttttgc 148141 tgcgcaaatg gctgcagaaa cagctgctaa aggttcaatc gaacatggtc ttaaaactct 148201 agaggttact gttaaaggac ctggttcagg ccgtgaagct gcaatccgtg cacttcaagc 148261 tgctggacta gaagtcactg ctatcagaga cgtaactcct gttcctcata acggatgccg 148321 tccaccaaaa cgtcgccgcg tgtaatttgt ttgtatagat tttgtgtccc tgtcaataat 148381 gggttatgat acagttattt atgaaacgaa tgcaccgact cgttgcctga gcacatacgg 148441 gactaaacaa tggggaattt cggatggaat ctcatatgat tctattcgag gtttcgacgt 148501 tttgaaggag ggttttaagt aatgatcgag attgaaaaac caaaaatcga aacggttgaa 148561 atcagcgacg atgccaaatt tggtaagttt gtcgtagagc cacttgagcg tggatatggt 148621 acaactctgg gtaactcctt acgtcgtatc ctcttatcct cactccctgg tgccgctgta 148681 acatcaatcc agatagatgg tgtactgcac gaattctcga caattgaagg cgttgtggaa 148741 gatgttacaa cgattatctt acacattaaa aagcttgcat tgaaaatcta ctctgatgaa 148801 gagaagacgc tagaaattga tgtacagggt gaaggaactg taacggcagc tgatattaca 148861 cacgatagtg atgtagagat cttaaatcct gatcttcata tcgcgactct tggtgagaat 148921 gcgagtttcc gagttcgcct tactgctcaa agaggacgtg ggtatacgcc tgctgacgca 148981 aacaagagag acgatcagcc aatcggcgtg attccgatcg attctatcta tacgccagtt 149041 tctcgtgtat cttatcaggt agagaacact cgtgtaggcc aagttgcaaa ctatgataaa 149101 cttacacttg atgtttggac tgatggaagc actggaccga aagaagcaat tgcgcttggt 149161 tcaaagattt taactgaaca ccttaatata ttcgttggtt taactgacga agctcaacat 149221 gctgaaatca tggttgaaaa agaagaagat caaaaagaga aagttcttga aatgacaatt 149281 gaagaattgg atctttctgt tcgttcttac aactgcttaa agcgtgcggg tattaacacg 149341 gttcaagagc ttgcgaacaa gacggaagaa gatatgatga aagttcgaaa tctaggacgc 149401 aaatcacttg aagaagtgaa agcgaaacta gaagaacttg gactcggact tcgcaaagac 149461 gattgactag tttcccttgt gaactaggat tttcgtgtgt ttattattca gaaacagcat 149521 tccaataaag gaggggacat cacatgtcat acagaaaact aggacgtacg agtgcacagc 149581 gtaaagctat gcttcgtgat cttacaactg atttgatcat caacgaaaga atcgaaacaa 149641 ctgaaacacg tgcgaaagaa cttcgctctg tagttgaaaa aatgatcacg cttggcaaac 149701 gcggtgatct tcacgctcgc cgtcaagctg ctgcatacat ccgcaacgag gttgcaaacg 149761 aagaaaataa tcaagatgca cttcaaaaat tattctctga cattgcaact cgttacgagg 149821 agcgccaagg tggatacaca cgtattatga agcttggtcc tcgccgtggt gacggagcac 149881 caatggcaat tatcgaattg gtttaatcac atatttttgt gtatctaaag aagggcggga 149941 cagtttctaa ctggatctat gccctttttt tagatactgc aacttttaat agagagaaaa 150001 gcagagcatt agctgagagg aggccggttt tccatgaatc aaaatcagtt gatatcggta 150061 gaggatatcg tatttcgata tcggaaggac gcagaaagac gagcactaga cggcgtctcc 150121 ctgcaggtgt atgagggtga atggcttgca atcgtaggtc ataacggttc agggaaatca 150181 acactggccc gggcattgaa tggtttaatt cttcctgaat caggcgacat tgaggttgcc 150241 gggattcaat tgacagagga atctgtttgg gaagtgcgta agaagatagg tatggtcttt 150301 caaaatccgg ataaccaatt tgtcggaacg actgttcgcg atgatgtggc ttttggttta 150361 gaaaacaatg gtgtaccgcg ggaagaaatg attgagagag tagactgggc agtaaaacag 150421 gtgaatatgc aagattttct cgatcaagag ccgcaccatc tctccggagg ccaaaagcag 150481 agagttgcga ttgcgggggt tattgccgca cgtcctgata ttattatctt agatgaagca 150541 acatccatgc ttgatccgat cgggcgagaa gaagtgcttg aaacggtaag acatttaaaa 150601 gagcagggca tggcgactgt catatccatt acacatgacc tgaatgaggc agcaaaagca 150661 gacaggatca ttgtcatgaa tggcggtaaa aaatatgctg aagggccgcc tgaagagatt 150721 tttaaattga ataaagaact tgttcgaatt gggcttgatt tacccttctc attccagctt 150781 agccagcttt taagagaaaa tggactggct ttggaagaaa accatttgac tcaggaaggg 150841 ctggtgaaag agctgtggac attacaatca aagatgtaga gcatcgctat cagatgaaga 150901 ccccgtttga gcgcctagca ctgtatgata tcaatgcatc gattaaagaa ggaagctacg 150961 tagccgttat cgggcataca ggctctggca agtccactct tctacagcac ctaaatggtc 151021 tcctgaagcc gacgaaggga cagatatcac taggcagcac tgtcattcag gcagggaaaa 151081 agaataaaga tctgaaaaaa cttcgtaaaa aagtcggaat cgttttccaa tttcctgagc 151141 atcaattatt cgaagaaaca gttcttaaag atatttcatt cggaccgatg aactttggtg 151201 ttaaaaaaga agatgctgaa caaaaagcga gagagatgct gcagcttgta ggtttatcag 151261 aagagctttt ggacaggtca ccctttgaat taagcggggg acaaatgcgc agagttgcaa 151321 ttgccggcgt acttgcaatg gaccctgaag tgcttgttct ggatgaaccg actgcaggat 151381 tggacccaag agggcgaaaa gagattatgg acatgtttta tgagcttcat caacgtggga 151441 acttgacgac gatccttgtg acacacagca tggaggatgc agctgcatac gctgatgaaa 151501 tgattgttat gcataaagga acgatacaag catcaggcag tccgcgtgat ctgtttttaa 151561 agggtgaaga gatggccggc tgggggctgg atcttcctga aacaataaaa ttccaaagac 151621 accttgaagc tgcactgggt gtgagattta atgagcctat gctcacaatc gaagatgccg 151681 ctgccgaaat ccgtgctctt tttcagggag agaagacttt atgatggaca gcatgattat 151741 cggcaagtat gtaccgggga cttcacttgt gcaccggctt gaccccagaa caaaactgat 151801 cacgatcttt ttatttgtct gcattgtatt cttagccaat aatgttcaga catatgcgtt 151861 gcttggttta tttacaattg gcgtcgtttc tttaacaaga gttcctttct cttttttaat 151921 gaaagggctg aagccaatca tctggattgt cctttttacg ttccttcttc acattcttat 151981 gacacatgaa ggaccgatta tctttcaaat aggttttttc aaagtctatg agggcggtct 152041 ggttcagggg atattcattt ctcttagatt cgtctatttg attttaatca caaccttatt 152101 aacgcttacg actacaccga ttgagattac cgatggaatg gagcagctgc tgaacccatt 152161 gaaaaaatta aagcttcctg ttcatgagct ggctcttatg atgtcaattt ctttacggtt 152221 tattccgaca ctgatggagg agacagataa gatcatgaag gctcagatgg cgcgaggcgt 152281 tgattttaca agcgggcctg tcaaagaaag agtgaaggct attgtcccgc ttcttgtccc 152341 gctcttcgtc agcgcattta aacgcgccga agagcttgcg gtggcaatgg aagcaagagg 152401 ctatcaaggc ggagaaggac gtacgaaata tagaaagctt gtatggacag gaaaagacac 152461 ttctgtcatt gtcagcttaa ttgtattagc tgctttgtta tttttcttaa gggcttagag 152521 gtgctgtatg agactgaaat gcacgatttc ttatgacgga catttgttta acggttatca 152581 ggttcagccg ggcaaaagaa cggttcagga tgaactggag aaggctttgg ctgtcctgca 152641 taagtcaaaa gacagaattc cggtcgtttc gtctggaaga acagacagcg gggttcacgc 152701 agccggacag gtgattcatt ttgacactcc gctgtctatc ccggctgaga gatggccata 152761 tgccttaaat gcactgcttc cggacgatat cgcagtcaaa caggcagaaa ttgcggatga 152821 tgggttccat gcacgattta gcgcagtcaa aaaagaatat cgctactttg tatacacgga 152881 gaaacacccg gacgtattta aacggcatta cgcttaccat ttttcatatc gccttaatgt 152941 gcaggacatg agagaagcgg caaagcatct tatagggaca catgatttta cgagcttttg 153001 cgcggctaaa acagaagtgc aggacaaggt aagaacgata tacgaacttg attggactga 153061 gacggctgac ggcctgcaaa tgcggatcac aggcagcggt ttcttatata atatggtcag 153121 aattattgcg ggtactttgc ttgatgcagg tattggaaaa atttctcccg atgaggtgaa 153181 atccatgctg gaagcgaagg atcgcgaagc ggcagggcgc acagcgccgg ggcacgggct 153241 atatttatgg aacgtttact atgacaacta aaccaggtgt ataatatttt cttgacagag 153301 tctgcataaa gttataagat atcatatggt atgtatttca accccacgat aagccccgga 153361 acttattgtg ttgtgaaata gaacgtaatc gaagtttatt gaaaatgaca gatcatttag 153421 gagggaaatt caatgcgtac aacacctatg gctaacgcaa gtactattga acgcaagtgg 153481 ttagttgttg atgctgctgg caagacttta ggtcgtcttt cttcagaagt tgcagctatc 153541 cttcgcggaa aacacaaacc aacttacaca ccacacgttg atactggaga tcatgtgatc 153601 atcatcaacg ctgaaaaaat cgagttaact ggtaaaaagt taactgacaa aatctactac 153661 cgtcacactc aacatccagg cggattaaaa tcaagaactg ctcttgaaat gcgtacaaac 153721 taccctgaga aaatgcttga gcttgctatc aaaggcatgc ttccaaaagg ttctctaggt 153781 cgtcaaatgt tcaaaaaatt gaacgtatac cgtggttctg agcatccaca cgaagcacaa 153841 aaacctgaag tttacgaact tcgcggttaa ttaaaaagga ggttaccaat ttggcacagg 153901 ttcaatatta cggtactggc cgtcgtaaaa gctctgtagc gcgtgtgcgt ttagttccag 153961 gagaaggccg tatcgtcgtt aataatcgtg aaatcagcga acatatccca tctgcagctt 154021 taatcgaaga tatcaaacaa ccattaactt tgactgaaac agctggcact tatgatgttt 154081 tagtaaacgt acatggaggc ggcctatctg gtcaagctgg agcaatccgt cacggtatcg 154141 ctcgtgcttt gcttgaagca gatccagaat accgtacaac tcttaaacgt gcaggtcttc 154201 tgactcgtga cgctcgtatg aaagaacgta aaaaatacgg tcttaaaggc gctcgtcgtg 154261 cacctcagtt ctcaaaacgt taattttacg ttttcaaaaa gctctcgacc ttgggttggg 154321 agcttttttc tttcaataaa acgtggcagt cccgcataaa aataacaact gaatggacgc 154381 ttgacggggt taagcaaatt gtttgtttat aaacggtctc tttgtaataa tcatggtaga 154441 tttcattctt attcaattgg aagttcggtc aatgtttatt atcgttatgt gatcagccca 154501 gctccatcta accactgtat ctcatccgtt aaagttcact gctgattctt aacccggaga 154561 aacaatagct ctcattgcta atggctttat gtaacgaagt aaaagtaaat ctgatgatat 154621 aaatcacata tctcctttgt gatttttttg cgtttttatg aacttttttc taaatatgca 154681 aagggaaagc gatatcaatc tagaaatatt tgttatactc tatacattaa agtaaggaga 154741 agattcatga atgcgttagt agctcataat agcaaagcct gggataaaaa agtagaaaca 154801 ggcaatgaat ggactgttgc tgttgaacag caggttatcg aacaagcaaa aaaaggcaat 154861 tgggatataa gggtaacacc aatgaaagat gtaccgaagg attggtttcc gcctatcaaa 154921 ggtctgaaag tactctgttt agcatcaggc ggcggccagc agggtccagt tttggcagcc 154981 gcaggcgcgg atgtcactgt attagataac tcagaaaaac agctgaatca ggatagaatg 155041 attgctgagc gagatggtct gacgatacac actgtcaaag gaagcatgga cgatttaagt 155101 gtatttaatg atgaatcatt tgatgtcatt gtacatcctg ttgccaatgt ttttgttgag 155161 aatgtcctcc cggtatggaa ggaagcgtac cgtgtgttga aaaggaacgg cattctaatc 155221 tcgggttttg tcaatcctgt tgtatttctg tttgatacag aattagaaca gcaaggtgtt 155281 ttaaaagtaa aacactctat tccatacgct gacccagaag atcttccgaa acataaagtg 155341 aaaaaactga tcgaaaataa tgaggctctg gaattcggcc attccttaga agaccaaatc 155401 aaaggccaaa ttgatgccgg ttttatcgtt actggttttt atgaagataa aggcggtttt 155461 gtattagacc aatatatcca tacatattct gcaacaagaa gcgtgaaagt atgaaaagca 155521 gcgacctgtt agaggggctg cttttttcat aaccaattac agaacatttg ttcctcaccc 155581 tgcagaaagc tgatttttta tcaatgttac accttcattt gggcgaattt ccaaccgaat 155641 tcgggcattg tttcatcatc caaacctcaa aataatcggt aaaaggagag tgaatttata 155701 tggcagaagt actgtctttt atggatgtga aacgccaaaa ggattttgaa ttagaaaaga 155761 acttgctcaa agaactctct ctgagacaaa ttatccagtc tgttaaggat tgtttggaac 155821 cattatttcc atttttacat gatgaacgag atattattac cgaaggctgt attgattttg 155881 cgattgaagc ttatttgtta ggcgggcgtt ttgggatatt cggctattac ggagaatcaa 155941 tgcagagtat cagtgcccgc tctgcaagag aagaagaaga gctgcgtatg gagttttttg 156001 attatctcta taattggata cacgagcaat acgcaacatt tgataaaaac actgtttatg 156061 aagcggcacg caagttcatt aaagattggt ggacagcagg gtttgttcaa agagaaaaac 156121 agtgtaagct tcgcatgcgg taatcatatt tcccgaccct gtcccatagt tatgtaataa 156181 cggacaagcg ggaggggaag ggatgaggaa aaagcttaaa tggctcagtt ttttgctagg 156241 cttcatcata ttactatttc tgttcaagta tcagttcagc aataacgact cttggaagcc 156301 gtggagcctg cccttgagcg gtaaaatcat ttatctagat ccaggtcatg gcgggcctga 156361 cggcggagca gtcggcggaa agctgttaga gaaggatgtt accctggaag tggcctttag 156421 agtcagggat tatcttcaag aacaaggagc gcttgttatc atgaccagag aaagtgatac 156481 tgatctcgct ccagaaggaa caaaaggcta tagccgacga aaagctgagg atctaagaca 156541 acgagtcaaa ttaataaacc attcagaggc ggagctctat atcagcattc atcttaatgc 156601 gattccgtca caaaaatgga gcggagccca aagcttttat tacgggaaat atgcggaaaa 156661 tgagaaagtc gcaaaataca ttcaggatga gctgagaaga aatctggaaa acacaacccg 156721 gaaagcaaag cggattcatg gtatctactt aatgcaaaac gtcaccaaac cgggggcgct 156781 tatagaagtc ggatttttat ccaatccaag tgaagcaacg ttgctcggta aaccgaaata 156841 tcaagacaag gtggcatctt ccatatataa aggcattttg cgatatttca cagaaaaagg 156901 agaccctccg gagtaatgga gggttttctt gtggttctaa gcataagaca cccgccattt 156961 atgtatgata taataataat tgtaaacgaa tacacaaaag ggtgaggttc gatgataaga 157021 gaagatgaag taagaaaact agtcggagaa atgcgcgaac cttttcttca aagacctctg 157081 ggagaattgg atgccgttaa ggaaattaaa ataaagcctg aaaaacggca tatcagtgta 157141 aaagtcgctc ttgcaaaaac aggaactgca gaacaaatgc agattcagca agagatcgta 157201 aacgtattaa aaggggcagg agctgagaca gtcggccttc gatttgaaga gctgcctgaa 157261 gaaacggttg ctaaattccg ggcgccgtca gctgagaaaa aaacattatt aaatatggat 157321 aacccgccag tctttcttgc tgtagcaagt ggaaaaggcg gcgtaggcaa gtcaactgtg 157381 tcagtaaacc tagctatttc tctggctcgt ctagggaaaa aggttggttt aattgatgcg 157441 gatatttatg ggttcagtgt gccggacatg atgggtatca ctgtgcgtcc aacaattgaa 157501 ggagagaaac ttcttcctgt tgaacgcttt ggagtaaagg tcatgtcaat gggctttttc 157561 gtagaagaaa atgccccggt cgtatggaga gggccgatgc tcggcaaaat gctgaataat 157621 tttttccatg aagtagagtg gggagaagta gactatatcg ttcttgatct tccgcctggt 157681 acaggggacg ttgctctcga tgtacataca atgcttccga gctgcaaaga aattatcgta 157741 tctacgccac atccgacagc tgcttttgtc gcggccagag cgggctctat ggcgattaaa 157801 accgatcatg aggtcgtggg tgtcatagag aacatggctt attatgaaag tgcaaagaca 157861 ggggaaagag aatatgtgtt tggaaaaggc ggaggagata aactggctga ggaactaaac 157921 gtgcctttgc tcggcagaat cccattgaaa cagcccgatt gggataagga ccaatttgct 157981 ccgtctgttt atgacgaaaa tcatccaatc ggagaaatat atcaggacat cgcaaaaaaa 158041 atagatgcaa aaatgtcagt gcaggtataa aaggtgaacc gggattccag atcccggctt 158101 tccctttatt cactttcttt tgctgtgtct tttgctgctt ttttcagctc atcttcgaac 158161 tgctttttgt aaagcggact agaaagtgtt tcgttaataa cctcttctaa ataactgcgg 158221 aattcttggc tttttgccag ctggctgtac tttttatcca tgccgggatc ctgcataacg 158281 ctcatcagca tcttctggta atctggatcc ttcatcagct ttttaatcac tttttcatgc 158341 tctgtctgaa gagttttggc aaagccctca gcaaaatcag tgtcttcaaa gatgtttttc 158401 caaaattctt cacctttttt agatgtgagt gttttttcta ttgttccttt aattgcatct 158461 tggtcaatca ccagcgcttc attcatggca tcatcattta ataattcctt aatagctttc 158521 tttccatcat cagtttttaa tatatcaaca accatttttt tggtctgatc atagtccata 158581 tccgctgctt ggtcttttgg agcgcaagct gttacagata ataacaaaaa acagctcatc 158641 aatagcgttt tggcttttga catgcttaag ctcctttcac atacttgtct tacctttaat 158701 atgattcatc tgtttggaat tatacataac aaaatatcgc tgttcgcgat ttttgagggg 158761 atgaataaag aaatgaaaag ccgtggttta gttcgttttt tcttttctat tttagctgtc 158821 ggggcgctta tcacgagtat tgtgggtttt gctttaaagt ggggagaata tagagggctg 158881 tttctaacat ttgaagcggg acagattttc tctgttttat tttggtttat cggtgtaggc 158941 atgattttca gtgtgatcag ccaaatgggt tttttcgtgt ttttaacagt tcatcggttt 159001 gcgcttgaga tattaaggtc ctcctctttg tggaatttgc tgcagttgtt tttcatcctg 159061 tttgttgctt ttgatttaat gtacgtgcgt tttttatttt ttggagagag cggagaatcg 159121 ctggctggct atgcgtggtt accggtgttt ttattgatct ttggagtgat tacagcttat 159181 ataaagcaaa agcagtcctc taagaaaaca tttgtgtcat cgttattttt gatggttgtg 159241 attaccgcat tagaatggtt ccctgcatta agagtaaatg atgaggactg gctttattta 159301 atgctttttc cgttaatggc atgtaatgcc ttccaattgc tgatgctgcc gaagtttgca 159361 gcaaagtaat tactttacct ctgcggattt ggcatcagaa tttgcgatga gatcacccac 159421 ggttacattt tttaatcctt tttctttcag ctgatggatg atatcaggca atgcttcttc 159481 tgtttgtttt gcagaatcgg aggcatgtaa aagaataatg tctccaccgg aaacttgctt 159541 ggtcacattg tcgatgattt tttcaactcc gggatttgtc cagtcttgag agttcacact 159601 gtaatgaacg actgtataat tgtattgctt tgcgaccttt agaacattct tattgaattg 159661 gccggtaggg ggtcttaata gctgtatgtc tttgacccct aacttttcaa aggctgtttg 159721 cgcacggttc atgtcctttt ttatttcgct gctctctaaa ttggcatagt ttttataagc 159781 gtagcccatg ctcccgattt gatggccgtc ctttacgata cgggccactg tgtcgggatg 159841 gcgttctgcc caagaagcgg acaggaaaaa cgttgcgttt ttaatcccgt ttgctttcag 159901 agtattaagt atcggttctg ctctctcatc accccagctg atatcgaaag taagtgaaat 159961 atctttagag tctgtttctc ctttataaat ggctttaggt ccggtgtcag ttgaaaacac 160021 gggaagcggg acagctcttt ggatataaaa aaagctggca gctgcaaatg cggcgataag 160081 tataataatt aattgtttta cccgtttaat gtgccacaca tagaagtgat tcactgatga 160141 tgcctcctta tcttgtccat cattcttgtt ttacatctta tgagcatgga caattgaata 160201 taaccgataa aatgtctctt cacatacagc ctaaattggg tgttgacctt ttgataatat 160261 ccgtgatata ttattattcg tcgctgataa acagctgaca tcaactaaaa gcttcattaa 160321 atactttgaa aaaagttgtt gacttaaaag aagctaaatg ttatagtaat aaagctgctt 160381 cgttaagcgg cagtaatgat ctttgaaaac taaacaagac aaaacgtacc tgttaattca 160441 tttttataaa tcgcacagcg atgtgcgtag tcagtcaaac tactttatcg gagagtttga 160501 tcctggctca ggacgaacgc tggcggcgtg cctaatacat gcaagtcgag cggacagatg 160561 ggagcttgct ccctgatgtt agcggcggac gggtgagtaa cacgtgggta acctgcctgt 160621 aagactggga taactccggg aaaccggggc taataccgga tggttgtttg aaccgcatgg 160681 ttcaaacata aaaggtggct tcggctacca cttacagatg gacccgcggc gcattagcta 160741 gttggtgagg taatggctca ccaaggcaac gatgcgtagc cgacctgaga gggtgatcgg 160801 ccacactggg actgagacac ggcccagact cctacgggag gcagcagtag ggaatcttcc 160861 gcaatggacg aaagtctgac ggagcaacgc cgcgtgagtg atgaaggttt tcggatcgta 160921 aagctctgtt gttagggaag aacaagtacc gttcgaatag ggcggtacct tgacggtacc 160981 taaccagaaa gccacggcta actacgtgcc agcagccgcg gtaatacgta ggtggcaagc 161041 gttgtccgga attattgggc gtaaagggct cgcaggcggt ttcttaagtc tgatgtgaaa 161101 gcccccggct caaccgggga gggtcattgg aaactgggga acttgagtgc agaagaggag 161161 agtggaattc cacgtgtagc ggtgaaatgc gtagagatgt ggaggaacac cagtggcgaa 161221 ggcgactctc tggtctgtaa ctgacgctga ggagcgaaag cgtggggagc gaacaggatt 161281 agataccctg gtagtccacg ccgtaaacga tgagtgctaa gtgttagggg gtttccgccc 161341 cttagtgctg cagctaacgc attaagcact ccgcctgggg agtacggtcg caagactgaa 161401 actcaaagga attgacgggg gcccgcacaa gcggtggagc atgtggttta attcgaagca 161461 acgcgaagaa ccttaccagg tcttgacatc ctctgacaat cctagagata ggacgtcccc 161521 ttcgggggca gagtgacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg 161581 gttaagtccc gcaacgagcg caacccttga tcttagttgc cagcattcag ttgggcactc 161641 taaggtgact gccggtgaca aaccggagga aggtggggat gacgtcaaat catcatgccc 161701 cttatgacct gggctacaca cgtgctacaa tggacagaac aaagggcagc gaaaccgcga 161761 ggttaagcca atcccacaaa tctgttctca gttcggatcg cagtctgcaa ctcgactgcg 161821 tgaagctgga atcgctagta atcgcggatc agcatgccgc ggtgaatacg ttcccgggcc 161881 ttgtacacac cgcccgtcac accacgagag tttgtaacac ccgaagtcgg tgaggtaacc 161941 ttttaggagc cagccgccga aggtgggaca gatgattggg gtgaagtcgt aacaaggtag 162001 ccgtatcgga aggtgcggct ggatcacctc ctttctaagg atattatacg gaatataaga 162061 ccttgggtct tataaacaga acgttccctg tcttgtttag ttttgaagga tcattccttc 162121 gaaacgtgtt ctttgaaaac tagataacag tagacatcac attcaagtaa tacaagatat 162181 cacatagtga ttctttttaa cggttaagtt agaaagggcg cacggtggat gccttggcac 162241 taggagccga tgaaggacgg gacgaacacc gatatgcttc ggggagctgt aagcaagctt 162301 tgatccggag atttccgaat ggggaaaccc accactcgta atggagtggt atccatatct 162361 gaattcatag gatatgagaa ggcagacccg gggaactgaa acatctaagt acccggagga 162421 agagaaagca aatgcgattc cctgagtagc ggcgagcgaa acgggattag cccaaaccaa 162481 gaggcttgcc tcttggggtt gtaggacact ctgtacggag ttacaaagga acgaggtaga 162541 tgaagaggtc tggaaaggcc cgccatagga ggtaacagcc ctgtagtcaa aacttcgttc 162601 tctcctgagt ggatcctgag tacggcggaa cacgtgaaat tccgtcggaa tccgggagga 162661 ccatctccca aggctaaata ctccctagtg accgatagtg aaccagtacc gtgagggaaa 162721 ggtgaaaagc accccggaag gggagtgaaa gagatcctga aaccgtgtgc ctacaagtag 162781 tcagagcccg ttaacgggtg atggcgtgcc ttttgtagaa tgaaccggcg agttacgatc 162841 tcgtgcaagg ttaagcagaa gatgcggagc cgcagcgaaa gcgagtctga atagggcgca 162901 tgagtacgtg gtcgtagacc cgaaaccagg tgatctaccc atgtccaggg tgaagttcag 162961 gtaacactga atggaggccc gaacccacgc acgttgaaaa gtgcggggat gaggtgtggg 163021 taggggtgaa atgccaatcg aacctggaga tagctggttc tctccgaaat agctttaggg 163081 ctagcctcaa ggtaagagtc ttggaggtag agcactgatt ggactagggg cccctaccgg 163141 gttaccgaat tcagtcaaac tccgaatgcc aatgacttat ccttgggagt cagactgcga 163201 gtgataagat ccgtagtcga aagggaaaca gcccagaccg ccagctaagg tcccaaagta 163261 tacgttaagt ggaaaaggat gtggagttgc ttagacaacc aggatgttgg cttagaagca 163321 gccaccattt aaagagtgcg taatagctca ctggtcgagt gactctgcgc cgaaaatgta 163381 ccggggctaa acgtatcacc gaagctgcgg actgttcttc gaacagtggt aggagagcgt 163441 tctaagggct gtgaagccag accggaagga ctggtggagc gcttagaagt gagaatgccg 163501 gtatgagtag cgaaagaggg gtgagaatcc cctccaccga atgcctaagg tttcctgagg 163561 aaggctcgtc cgctcagggt tagtcgggac ctaagccgag gccgaaaggc gtaggcgatg 163621 gacaacaggt tgatattcct gtaccacctc ctcaccattt gagcaatggg gggacgcagg 163681 aggatagggt aagcgcggta ttggatatcc gcgtccaagc agttaggctg ggaaataggc 163741 aaatccgttt cccataaggc tgagctgtga tggcgagcga aatatagtag cgaagttcct 163801 gattccacac tgccaagaaa agcctctagc gaggtgagag gtgcccgtac cgcaaaccga 163861 cacaggtagg cgaggagaga atcctaaggt gatcgagaga actctcgtta aggaactcgg 163921 caaaatgacc ccgtaacttc gggagaaggg gtgctctgtt agggtgcaag cccgagagag 163981 ccgcagtgaa taggcccagg cgactgttta gcaaaaacac aggtctctgc gaagccgtaa 164041 ggcgaagtat aggggctgac gcctgcccgg tgctggaagg ttaagaggag cgcttagcgt 164101 aagcgaaggt gcgaattgaa gccccagtaa acggcggccg taactataac ggtcctaagg 164161 tagcgaaatt ccttgtcggg taagttccga cccgcacgaa aggcgcaacg atctgggcac 164221 tgtctcaacg agagactcgg tgaaattata gtacctgtga agatgcaggt tacccgcgac 164281 aggacggaaa gaccccgtgg agctttactg cagcctgata ttgaatgttg gtacagcttg 164341 tacaggatag gtaggagcct tggaaaccgg agcgccagct tcggtggagg catcggtggg 164401 atactaccct ggctgtattg accttctaac ccgccgccct tatcgggcgg ggagacagtg 164461 tcaggtgggc agtttgactg gggcggtcgc ctcctaaaag gtaacggagg cgcccaaagg 164521 ttccctcaga atggttggaa atcattcgca gagtgtaaag gcacaaggga gcttgactgc 164581 gagacctaca agtcgagcag ggacgaaagt cgggcttagt gatccggtgg ttccgcatgg 164641 aagggccatc gctcaacgga taaaagctac cccggggata acaggcttat ctcccccaag 164701 agtccacatc gacggggagg tttggcacct cgatgtcggc tcatcgcatc ctggggctgt 164761 agtcggtccc aagggttggg ctgttcgccc attaaagcgg tacgcgagct gggttcagaa 164821 cgtcgtgaga cagttcggtc cctatccgtc gcgggcgcag gaaatttgag aggagctgtc 164881 cttagtacga gaggaccggg atggacgcac cgctggtgta ccagttgttc tgccaagggc 164941 atcgctgggt agctatgtgc ggacgggata agtgctgaaa gcatctaagc atgaagcccc 165001 cctcaagatg agatttccca ttccgcaagg aagtaagatc cctgaaagat gatcaggttg 165061 ataggtctga ggtggaagtg tggcgacaca tggagctgac agatactaat cgatcgagga 165121 cttaaccata tttttgaatg atgtcacatc tgttatctag ttttgagaga acactctcaa 165181 tttgtttggt ggcgatagcg aagaggtcac acccgttccc ataccgaaca cggaagttaa 165241 gctcttcagc gccgatggta gtcgggggtt tccccctgtg agagtaggac gccgccaagc 165301 agatttatta attctaccat gtttgtttat gaagctttat attattccgc agtagctcag 165361 tggtagagct atcggctgtt aaccgatcgg tcgtaggttc gaatcctacc tgcggagcca 165421 ttgcttccat agctcagcag gtagagcact tccatggtaa ggaagaggtc agcggttcga 165481 gcccgcttgg aagcttaaat gtattattac caaggtttct cataaggaga aagctttttt 165541 tattgcgata tgcggaagta gttcagtggt agaacaccac cttgccaagg tgggggtcgc 165601 gggttcgaat cccgtcttcc gctccattta tcctaacggg atattgtaaa ttgaattgcg 165661 cccgtagctc aattggatag agcgtttgac tacggatcaa aaggttaggg gttcgactcc 165721 tctcgggcgc gccatatctt ttaatagaat agataggaaa tcgggaagta gctcagcttg 165781 gtagagcaca tggtttggga ccatggggtc gcaggttcga atcctgtctt cccgaccatt 165841 ttttatgggg ccttagctca gctgggagag cgcctgcttt gcacgcagga ggtcagcggt 165901 tcgatcccgc taggctccac caaaagtttt taaaaaagtt attgactttg aagaagtgac 165961 attgtatact aataaagttg ctttaacaaa gcggacaaac aaaatgatct ttgaaaacta 166021 aacaagacaa aacgtacctg ttaattcagt ttttaaaaat cgcacagcga tgtgcgtagt 166081 cagtcaaact actttatcgg agagtttgat cctggctcag gacgaacgct ggcggcgtgc 166141 ctaatacatg caagtcgagc ggacagatgg gagcttgctc cctgatgtta gcggcggacg 166201 ggtgagtaac acgtgggtaa cctgcctgta agactgggat aactccggga aaccggggct 166261 aataccggat ggttgtttga accgcatggt tcaaacataa aaggtggctt cggctaccac 166321 ttacagatgg acccgcggcg cattagctag ttggtgaggt aacggctcac caaggcaacg 166381 atgcgtagcc gacctgagag ggtgatcggc cacactggga ctgagacacg gcccagactc 166441 ctacgggagg cagcagtagg gaatcttccg caatggacga aagtctgacg gagcaacgcc 166501 gcgtgagtga tgaaggtttt cggatcgtaa agctctgttg ttagggaaga acaagtaccg 166561 ttcgaatagg gcggtacctt gacggtacct aaccagaaag ccacggctaa ctacgtgcca 166621 gcagccgcgg taatacgtag gtggcaagcg ttgtccggaa ttattgggcg taaagggctc 166681 gcaggcggtt tcttaagtct gatgtgaaag cccccggctc aaccggggag ggtcattgga 166741 aactggggaa cttgagtgca gaagaggaga gtggaattcc acgtgtagcg gtgaaatgcg 166801 tagagatgtg gaggaacacc agtggcgaag gcgactctct ggtctgtaac tgacgctgag 166861 gagcgaaagc gtggggagcg aacaggatta gataccctgg tagtccacgc cgtaaacgat 166921 gagtgctaag tgttaggggg tttccgcccc ttagtgctgc agctaacgca ttaagcactc 166981 cgcctgggga gtacggtcgc aagactgaaa ctcaaaggaa ttgacggggg cccgcacaag 167041 cggtggagca tgtggtttaa ttcgaagcaa cgcgaagaac cttaccaggt cttgacatcc 167101 tctgacaatc ctagagatag gacgtcccct tcgggggcag agtgacaggt ggtgcatggt 167161 tgtcgtcagc tcgtgtcgtg agatgttggg ttaagtcccg caacgagcgc aacccttgat 167221 cttagttgcc agcattcagt tgggcactct aaggtgactg ccggtgacaa accggaggaa 167281 ggtggggatg acgtcaaatc atcatgcccc ttatgacctg ggctacacac gtgctacaat 167341 ggacagaaca aagggcagcg aaaccgcgag gttaagccaa tcccacaaat ctgttctcag 167401 ttcggatcgc agtctgcaac tcgactgcgt gaagctggaa tcgctagtaa tcgcggatca 167461 gcatgccgcg gtgaatacgt tcccgggcct tgtacacacc gcccgtcaca ccacgagagt 167521 ttgtaacacc cgaagtcggt gaggtaacct tttaggagcc agccgccgaa ggtgggacag 167581 atgattgggg tgaagtcgta acaaggtagc cgtatcggaa ggtgcggctg gatcacctcc 167641 tttctaagga tattatacgg aatataagac cttgggtctt ataaacagaa cgttccctgt 167701 cttgtttagt tttgaaggat cattccttcg aaacgtgttc tttgaaaact agataacagt 167761 agacatcaca ttcaagtaat acaagatatc acatagtgat tctttttaac ggttaagtta 167821 gaaagggcgc acggtggatg ccttggcact aggagccgat gaaggacggg acgaacaccg 167881 atatgcttcg gggagctgta agcaagcttt gatccggaga tttccgaatg gggaaaccca 167941 ccactcgtaa tggagtggta tccatatctg aattcatagg atatgagaag gcagacccgg 168001 ggaactgaaa catctaagta cccggaggaa gagaaagcaa atgcgattcc ctgagtagcg 168061 gcgagcgaaa cgggattagc ccaaaccaag aggcttgcct cttggggttg taggacactc 168121 tgtacggagt tacaaaggaa cgaggtagat gaagaggtct ggaaaggccc gccataggag 168181 gtaacagccc tgtagtcaaa acttcgttct ctcctgagtg gatcctgagt acggcggaac 168241 acgtgaaatt ccgtcggaat ccgggaggac catctcccaa ggctaaatac tccctagtga 168301 ccgatagtga accagtaccg tgagggaaag gtgaaaagca ccccggaagg ggagtgaaag 168361 agatcctgaa accgtgtgcc tacaagtagt cagagcccgt taacgggtga tggcgtgcct 168421 tttgtagaat gaaccggcga gttacgatct cgtgcaaggt taagcagaag atgcggagcc 168481 gcagcgaaag cgagtctgaa tagggcgcat gagtacgtgg tcgtagaccc gaaaccaggt 168541 gatctaccca tgtccagggt gaagttcagg taacactgaa tggaggcccg aacccacgca 168601 cgttgaaaag tgcggggatg aggtgtgggt aggggtgaaa tgccaatcga acctggagat 168661 agctggttct ctccgaaata gctttagggc tagcctcaag gtaagagtct tggaggtaga 168721 gcactgattg gactaggggc ccctaccggg ttaccgaatt cagtcaaact ccgaatgcca 168781 atgacttatc cttgggagtc agactgcgag tgataagatc cgtagtcgaa agggaaacag 168841 cccagaccgc cagctaaggt cccaaagtat acgttaagtg gaaaaggatg tggagttgct 168901 tagacaacca ggatgttggc ttagaagcag ccaccattta aagagtgcgt aatagctcac 168961 tggtcgagtg actctgcgcc gaaaatgtac cggggctaaa cgtatcaccg aagctgcgga 169021 ctgttcttcg aacagtggta ggagagcgtt ctaagggctg tgaagccaga ccggaaggac 169081 tggtggagcg cttagaagtg agaatgccgg tatgagtagc gaaagagggg tgagaatccc 169141 ctccaccgaa tgcctaaggt ttcctgagga aggctcgtcc gctcagggtt agtcgggacc 169201 taagccgagg ccgaaaggcg taggcgatgg acaacaggtt gatattcctg taccacctcc 169261 tcaccatttg agcaatgggg ggacgcagga ggatagggta agcgcggtat tggatatccg 169321 cgtccaagca gttaggctgg gaaataggca aatccgtttc ccataaggct gagctgtgat 169381 ggcgagcgaa atatagtagc gaagttcctg attccacact gccaagaaaa gcctctagcg 169441 aggtgagagg tgcccgtacc gcaaaccgac acaggtaggc gaggagagaa tcctaaggtg 169501 atcgagagaa ctctcgttaa ggaactcggc aaaatgaccc cgtaacttcg ggagaagggg 169561 tgctctgtta gggtgcaagc ccgagagagc cgcagtgaat aggcccaggc gactgtttag 169621 caaaaacaca ggtctctgcg aagccgtaag gcgaagtata ggggctgacg cctgcccggt 169681 gctggaaggt taagaggagc gcttagcgta agcgaaggtg cgaattgaag ccccagtaaa 169741 cggcggccgt aactataacg gtcctaaggt agcgaaattc cttgtcgggt aagttccgac 169801 ccgcacgaaa ggcgcaacga tctgggcact gtctcaacga gagactcggt gaaattatag 169861 tacctgtgaa gatgcaggtt acccgcgaca ggacggaaag accccgtgga gctttactgc 169921 agcctgatat tgaatgttgg tacagcttgt acaggatagg taggagcctt ggaaaccgga 169981 gcgccagctt cggtggaggc atcggtggga tactaccctg gctgtattga ccttctaacc 170041 cgccgccctt atcgggcggg gagacagtgt caggtgggca gtttgactgg ggcggtcgcc 170101 tcctaaaagg taacggaggc gcccaaaggt tccctcagaa tggttggaaa tcattcgcag 170161 agtgtaaagg cacaagggag cttgactgcg agacctacaa gtcgagcagg gacgaaagtc 170221 gggcttagtg atccggtggt tccgcatgga agggccatcg ctcaacggat aaaagctacc 170281 ccggggataa caggcttatc tcccccaaga gtccacatcg acggggaggt ttggcacctc 170341 gatgtcggct catcgcatcc tggggctgta gtcggtccca agggttgggc tgttcgccca 170401 ttaaagcggt acgcgagctg ggttcagaac gtcgtgagac agttcggtcc ctatccgtcg 170461 cgggcgcagg aaatttgaga ggagctgtcc ttagtacgag aggaccggga tggacgcacc 170521 gctggtgtac cagttgttct gccaagggca tcgctgggta gctatgtgcg gacgggataa 170581 gtgctgaaag catctaagca tgaagccccc ctcaagatga gatttcccat tccgcaagga 170641 agtaagatcc ctgaaagatg atcaggttga taggtctgag gtggaagtgt ggcgacacat 170701 ggagctgaca gatactaatc gatcgaggac ttaaccatat ttttgaatga tgtcacacct 170761 gttatctagt tttgagagaa cactctcaat ttgtttggtg gcgatagcga agaggtcaca 170821 cccgttccca taccgaacac ggaagttaag ctcttcagcg ccgatggtag tcgggggttt 170881 ccccctgtga gagtaggacg ccgccaagca attgcacatt agtgtaattt tttaaaaaag 170941 ttattgactt tgaagaagtg acattgtata ctaataaagt tgctttaaca aagcggacaa 171001 acaaaatgat ctttgaaaac taaacaagac aaaacgtacc tgttaattca gtttttaaaa 171061 atcgcacagc gatgtgcgta gtcagtcaaa ctactttatc ggagagtttg atcctggctc 171121 aggacgaacg ctggcggcgt gcctaataca tgcaagtcga gcggacagat gggagcttgc 171181 tccctgatgt tagcggcgga cgggtgagta acacgtgggt aacctgcctg taagactggg 171241 ataactccgg gaaaccgggg ctaataccgg atggttgttt gaaccgcatg gttcaaacat 171301 aaaaggtggc ttcggctacc acttacagat ggacccgcgg cgcattagct agttggtgag 171361 gtaacggctc accaaggcaa cgatgcgtag ccgacctgag agggtgatcg gccacactgg 171421 gactgagaca cggcccagac tcctacggga ggcagcagta gggaatcttc cgcaatggac 171481 gaaagtctga cggagcaacg ccgcgtgagt gatgaaggtt ttcggatcgt aaagctctgt 171541 tgttagggaa gaacaagtac cgttcgaata gggcggtacc ttgacggtac ctaaccagaa 171601 agccacggct aactacgtgc cagcagccgc ggtaatacgt aggtggcaag cgttgtccgg 171661 aattattggg cgtaaagggc tcgcaggcgg tttcttaagt ctgatgtgaa agcccccggc 171721 tcaaccgggg agggtcattg gaaactgggg aacttgagtg cagaagagga gagtggaatt 171781 ccacgtgtag cggtgaaatg cgtagagatg tggaggaaca ccagtggcga aggcgactct 171841 ctggtctgta actgacgctg aggagcgaaa gcgtggggag cgaacaggat tagataccct 171901 ggtagtccac gccgtaaacg atgagtgcta agtgttaggg ggtttccgcc ccttagtgct 171961 gcagctaacg cattaagcac tccgcctggg gagtacggtc gcaagactga aactcaaagg 172021 aattgacggg ggcccgcaca agcggtggag catgtggttt aattcgaagc aacgcgaaga 172081 accttaccag gtcttgacat cctctgacaa tcctagagat aggacgtccc cttcgggggc 172141 agagtgacag gtggtgcatg gttgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc 172201 cgcaacgagc gcaacccttg atcttagttg ccagcattca gttgggcact ctaaggtgac 172261 tgccggtgac aaaccggagg aaggtgggga tgacgtcaaa tcatcatgcc ccttatgacc 172321 tgggctacac acgtgctaca atggacagaa caaagggcag cgaaaccgcg aggttaagcc 172381 aatcccacaa atctgttctc agttcggatc gcagtctgca actcgactgc gtgaagctgg 172441 aatcgctagt aatcgcggat cagcatgccg cggtgaatac gttcccgggc cttgtacaca 172501 ccgcccgtca caccacgaga gtttgtaaca cccgaagtcg gtgaggtaac cttttaggag 172561 ccagccgccg aaggtgggac agatgattgg ggtgaagtcg taacaaggta gccgtatcgg 172621 aaggtgcggc tggatcacct cctttctaag gatattatac ggaatataag accttgggtc 172681 ttataaacag aacgttccct gtcttgttta gttttgaagg atcattcctt cgaaacgtgt 172741 tctttgaaaa ctagataaca gtagacatca cattcaagta atacaagata tcacatagtg 172801 attcttttta acggttaagt tagaaagggc gcacggtgga tgccttggca ctaggagccg 172861 atgaaggacg ggacgaacac cgatatgctt cggggagctg taagcaagct ttgatccgga 172921 gatttccgaa tggggaaacc caccactcgt aatggagtgg tatccatatc tgaattcata 172981 ggatatgaga aggcagaccc ggggaactga aacatctaag tacccggagg aagagaaagc 173041 aaatgcgatt ccctgagtag cggcgagcga aacgggatta gcccaaacca agaggcttgc 173101 ctcttggggt tgtaggacac tctgtacgga gttacaaagg aacgaggtag atgaagaggt 173161 ctggaaaggc ccgccatagg aggtaacagc cctgtagtca aaacttcgtt ctctcctgag 173221 tggatcctga gtacggcgga acacgtgaaa ttccgtcgga atccgggagg accatctccc 173281 aaggctaaat actccctagt gaccgatagt gaaccagtac cgtgagggaa aggtgaaaag 173341 caccccggaa ggggagtgaa agagatcctg aaaccgtgtg cctacaagta gtcagagccc 173401 gttaacgggt gatggcgtgc cttttgtaga atgaaccggc gagttacgat ctcgtgcaag 173461 gttaagcaga agatgcggag ccgcagcgaa agcgagtctg aatagggcgc atgagtacgt 173521 ggtcgtagac ccgaaaccag gtgatctacc catgtccagg gtgaagttca ggtaacactg 173581 aatggaggcc cgaacccacg cacgttgaaa agtgcgggga tgaggtgtgg gtaggggtga 173641 aatgccaatc gaacctggag atagctggtt ctctccgaaa tagctttagg gctagcctca 173701 aggtaagagt cttggaggta gagcactgat tggactaggg gcccctaccg ggttaccgaa 173761 ttcagtcaaa ctccgaatgc caatgactta tccttgggag tcagactgcg agtgataaga 173821 tccgtagtcg aaagggaaac agcccagacc gccagctaag gtcccaaagt atacgttaag 173881 tggaaaagga tgtggagttg cttagacaac caggatgttg gcttagaagc agccaccatt 173941 taaagagtgc gtaatagctc actggtcgag tgactctgcg ccgaaaatgt accggggcta 174001 aacgtatcac cgaagctgcg gactgttctt cgaacagtgg taggagagcg ttctaagggc 174061 tgtgaagcca gaccggaagg actggtggag cgcttagaag tgagaatgcc ggtatgagta 174121 gcgaaagagg ggtgagaatc ccctccaccg aatgcctaag gtttcctgag gaaggctcgt 174181 ccgctcaggg ttagtcggga cctaagccga ggccgaaagg cgtaggcgat ggacaacagg 174241 ttgatattcc tgtaccacct cctcaccatt tgagcaatgg ggggacgcag gaggataggg 174301 taagcgcggt attggatatc cgcgtccaag cagttaggct gggaaatagg caaatccgtt 174361 tcccataagg ctgagctgtg atggcgagcg aaatatagta gcgaagttcc tgattccaca 174421 ctgccaagaa aagcctctag cgaggtgaga ggtgcccgta ccgcaaaccg acacaggtag 174481 gcgaggagag aatcctaagg tgatcgagag aactctcgtt aaggaactcg gcaaaatgac 174541 cccgtaactt cgggagaagg ggtgctctgt tagggtgcaa gcccgagaga gccgcagtga 174601 ataggcccag gcgactgttt agcaaaaaca caggtctctg cgaagccgta aggcgaagta 174661 taggggctga cgcctgcccg gtgctggaag gttaagagga gcgcttagcg taagcgaagg 174721 tgcgaattga agccccagta aacggcggcc gtaactataa cggtcctaag gtagcgaaat 174781 tccttgtcgg gtaagttccg acccgcacga aaggcgcaac gatctgggca ctgtctcaac 174841 gagagactcg gtgaaattat agtacctgtg aagatgcagg ttacccgcga caggacggaa 174901 agaccccgtg gagctttact gcagcctgat attgaatgtt ggtacagctt gtacaggata 174961 ggtaggagcc ttggaaaccg gagcgccagc ttcggtggag gcatcggtgg gatactaccc 175021 tggctgtatt gaccttctaa cccgccgccc ttatcgggcg gggagacagt gtcaggtggg 175081 cagtttgact ggggcggtcg cctcctaaaa ggtaacggag gcgcccaaag gttccctcag 175141 aatggttgga aatcattcgc agagtgtaaa ggcacaaggg agcttgactg cgagacctac 175201 aagtcgagca gggacgaaag tcgggcttag tgatccggtg gttccgcatg gaagggccat 175261 cgctcaacgg ataaaagcta ccccggggat aacaggctta tctcccccaa gagtccacat 175321 cgacggggag gtttggcacc tcgatgtcgg ctcatcgcat cctggggctg tagtcggtcc 175381 caagggttgg gctgttcgcc cattaaagcg gtacgcgagc tgggttcaga acgtcgtgag 175441 acagttcggt ccctatccgt cgcgggcgca ggaaatttga gaggagctgt ccttagtacg 175501 agaggaccgg gatggacgca ccgctggtgt accagttgtt ctgccaaggg catcgctggg 175561 tagctatgtg cggacgggat aagtgctgaa agcatctaag catgaagccc ccctcaagat 175621 gagatttccc attccgcaag gaagtaagat ccctgaaaga tgatcaggtt gataggtctg 175681 aggtggaagt gtggcgacac atggagctga cagatactaa tcgatcgagg acttaaccat 175741 atttttgaat gatgtcacac ctgttatcta gttttgagag aacactctca atttgtttgg 175801 tggcgatagc gaagaggtca cacccgttcc cataccgaac acggaagtta agctcttcag 175861 cgccgatggt agtcgggggt ttccccctgt gagagtagga cgccgccaag caagcttaaa 175921 cccagctcat tgagctgggt tttttgtttt atatctgtgc cgatttgctt tcgtcagtat 175981 ccattttatc aagcttctgc tttttaaagt tttctaatac ttttgaattc caatacaatc 176041 cctagcatga tcaacatgag agtcataaat aatcaaaatg cagtttgtac gggagactca 176101 tccagactcc atccgactgc gattggcagg atagagccgc caatccattg gcagcgaaca 176161 gcatgcttgt cgtttgttct gtttttccat gataaaattg attggtgaca ataaaataat 176221 ggcgaacatg ccggccataa ataagtccta agaaaaaact aagaataatc cctgcaaaag 176281 ctgttttatt gattgccaaa atacagagtt aaatgaggcc gctcatattt atcagcctga 176341 gataatgatg ataggttatt ttttcggaaa ccagctcggg ttgccaaatg agagaaaaga 176401 tattactgtc attaaaacga ttcttggttt catccggata tgataaaatg tctcagacta 176461 tatttgagcc atttttttct tcagcaatca tcttgcgtaa ttgataaaaa tttattatga 176521 tactctttgt atgacaactc cttgcctcaa tacaatatac tcaacgtttc cccgttttct 176581 ccggtcgttt ttcttttcat tttctcccgt aaaataaaaa aagctcccaa tacaatagat 176641 atggtgcgga tttatttttt actaaaaagg agtcgttata tttgaataat agttttacat 176701 taaaacagca atggttcggg aatatccgaa aagacattct tgctggcatt ttagttgcgt 176761 tagcgttaat acctgaagcg attggctttt ctattatagc cggtgtggat ccgatggtcg 176821 gtctttatgc gtcattttgc atagccatta ttatttctat ttttggtggc agacctggca 176881 tgatttcagc tgcgacaggc tcaatggcag tcgttatggt gtcgctggtt gctgatcatg 176941 ggcttcagta tttatttgcg gctacgattt tgacaggcat tattcaggtg attttaggta 177001 tcagtaaaat tgcaagatta atgaaattca tcccgcgttc tgtgatgatc gggtttgtga 177061 atgcgctggc gatccttatc ttctctgcgc agcttcccca gtttgaaggt gcttcttgga 177121 gcatgtatgc gatgcttgcc gggtcgttgg ttattattta tgtgctgcca aggtttacga 177181 ctgctgttcc gtctccgctt gtggcgatta ttgtgatgac aattattgcg gtcactttcc 177241 atgtggatgt gcggacggtt ggtgatatgg gcaatatttc tagttcattg cctcatttct 177301 taatccctga tgttccgttt acctttgaaa cactgcaaat tatttttcct tattcaattg 177361 ctttagcgtt tgtcgggttg cttgaatctt tgctgacagc acagattatt gatgaaatga 177421 cggatacgga tagtgataaa aataaagaga gccgcggaca gggaattgcg aatatcgtga 177481 ctggattctt tggcggaatg gcaggctgcg ctatgatcgg acaatctgtc attaatacaa 177541 aagcgggcgg tcgcggacgt ttgtcagcat ttgttgccgg tgcttttctg atgtttttaa 177601 ttgcggtgtt aagtcatgtc gtggtgaaaa tcccaatggc ggcgttagta gctgtaatgg 177661 ttatggtgtc tgtcggcact tttgattggt cttctttaaa aggtctcaaa aaagcgccgc 177721 tcacggactc gattgtcatg gttgtgactg tggttacggt tgttgtgacg gatgacttat 177781 ctaagggtgt atttgtcggt gttcttttaa gtgccgtgtt ctttgtagca aaaatctcga 177841 agctgaaaat cgtttctcat gcagaggatc aaaagcttag aacgtatcaa gtgaaggggc 177901 aaatcttttt tgcgtcagtg actgatctta cgaatgcgtt tatatatcaa gaggatattg 177961 agcgggttgt gattgactta actgaagctc acgtatggga cgattctggt gcggccgcac 178021 ttgataagat tgttgcgaag tttaaggaac aaggcattga agctgagtta aaaggtttga 178081 ataaagcgag taaatctcta atgaaacaga tggcataaaa tagagaagcc cagatgaatg 178141 agatctgggc ttttttatat aacatacact taagcagcat tgatataata gagagaagag 178201 aaattttaaa taggggactt gcatatgatg cttcagaagc tgaaccgtgt attggggaga 178261 gtgatgccgc tgttaacgcc gactagtgtg gtgctgggcg tgctgctgtc tcagttttta 178321 aatgggtatg aatgggctgt gccttggatc tttgctttta ttacgtttgc aggcagtttg 178381 agcgcgaact ttcaatcttt gagacatgca ttgtctcatc ctctccctat gattcttgca 178441 ctattcgttc ttcatatttt catgccgctt tttgcttggg gcagcggcca tcttatattt 178501 aaaggtgatc ctttgacgat taccggttta acattggctg ttgtgattcc tacggggatt 178561 acaagcttga tttgggcagc gatgtacaaa gggaatgtcg gtttgacact ttcgattatt 178621 ttagttgata ctgtgctgtc accgctaatc gtaccgctga gtctttcatt gctggccggc 178681 gctcaggttc acatggatgt gtggggaatg atgaaaggtc tgattgtaat ggtcgtgatt 178741 ccttcttttt tgggcatgct gtttaatcag atgtcatctc cagaaagaac tgcgtttgtg 178801 agcagtgcgc tgtcgccttt ttcaaagctt tgcttgatgg cagtgattgc gattaacagt 178861 tcagcgattg ctccttattt caaatccatt gatttgagat ttgcaggaat agctgtaacg 178921 gtattcttta tcgcgttaac aggttatgcc gctgcttggc tgatcggaaa aatgatgaaa 178981 aggcggcaag aggaaatagt ctctcttata tttacgggag gcatgaggaa tattagtgcc 179041 ggcgcagttc ttgccgttac gttcttcccg tctcaggttg ccgttcctgt tgtgatcggc 179101 atgctgtttc agcagatatt ggctgctttg tttggctata tgctgaatcg ttttgaatta 179161 aaaccaatgt tgcagaaggc ataaaaaaac cgctcatagg gttgagcggt tttttccgta 179221 tagccattcg agcgcgttga tgaactgttt gcagaaatac ttgtggtggt gcaccgctcc 179281 tttttcaatt gaaagacaca actggtcttc agtgaagcct ttttctttta gactttgatg 179341 aacttgcttt gtttttttca gcatatgtcg ctgaatggat tgtttttcac ggccttcttc 179401 actcccgata gacatgaaaa cacgtgcagt gccgggcttt aaagaagata tatgaatggt 179461 ttccgctgcg ttctcgtacc agtatgaacc tgatatagag cctattttcc cgaacattga 179521 cggatatttt aatatggcga acattgagat gaggccgcct aatgaggcac cgatcattcc 179581 tcttgactgc ggttccctgg tgacgttcca gttttcttcg attagcggaa tgaactggtt 179641 cgttatatca gacagatagt gatatcccat tccgccgaag tccgtgaacc gatcactgag 179701 tgatgcagcc ggccatgggg tgtattcatc aagccggttt tcgggttcga taccgatcag 179761 cacgagttca gggagccttt gctgttgaaa ggcgctttct agtaattcga tttggttttg 179821 gaacaaagaa ctgccatcct gcacgtaaac agcaggaaat cccccgctgt ctgtgctgta 179881 ggaaggaggg aggtacagcg tgaacctcct gttgccggct ttgtgttctg aaagagatcc 179941 tttcaagcat tctccccctt tttttgcttg aaaagcagat ataagaaata aggaactccg 180001 aggatcgcca aaatgatgcc tgcgggcact tctgcgggct gaaaaaacag ttttccggca 180061 aagtctgcgc ttatcacaag aagcatcccg attaaaccgc tcagtggcag gatatagcga 180121 tgttcgacgc cagccagtct ccgtgagata tggggagcaa ttaagccgac aaacgccata 180181 cttcccgcta cggagacaca ggcgctgatg attgctacac aggcaacgag aaggatggtt 180241 ttttctttat ttgatgaaat accgaggctt ctgactgtgt cttcatcaaa acgaatggtg 180301 tcgagcaggc gggatttgcc gataagaatc ggtataaaca gcagcatcca tgggagtaca 180361 gctgtaatat acgtccagtt ggcagaccag atgcttccgt ttttccacac catggccatt 180421 tgatagtctt gcgggtccat ttttaaagat aaaaacaaag acagggcgct gaatcctgaa 180481 ttgatcgcaa tccctaccaa aataattctt cctgaatcta aattgcctct gtgccatgca 180541 aatatgtaaa tcaggatcgc cgcgatgagc ccgcctatca atccaaagag cggcattccc 180601 atcgctgcag ctatggatgt cacttccttc tggccttgga ataagagcat aaacgctaca 180661 atgccagctc ctgcccctgc gttgattccg agaattccag ggtcagcaag cccgtttctc 180721 gtgatggcct ggataacagc gcctgcaatg ccaagaccga gtccaataat agcagccatg 180781 acaacccgcg gcagtcttaa atcgaacagc aaaatttcat actgcggatt cgggtcgatt 180841 tgaaaaagag tggagagcag ctcagcagga cgaacagaaa atgatccgct cgttaagctg 180901 aaatagctga caacaagaat caaagcgatg aacaatgcat attttttagc cattttgctc 180961 ccctcctttt cgtttaatta aataaaggaa gaaaggtacg ccgataatgg atgttacgac 181021 ctcaatcggt gtttcaaacg gatagttgat aaatctgctt gcgagatcac acagggttaa 181081 aaagattccg cccaaaatac aggaacacgg aatcagcctg ctgtaatcag agccgacgag 181141 aaatctcgtg atatgcggaa caaccaaccc gacaaacgca atttttccgg ccagcgctac 181201 ggcactgccg gttagaatga tgacggaaag catcgccatg attttaatgg tttttttctt 181261 ttgccccagg cttttagaaa tgtcgtcccc taatgataca gcggttacct ttttgctgag 181321 agaaatggcc attataatgc caatcaggaa aaacggagcg gcaagcttca ggaaatctgg 181381 actcatttga tgaagtctgg cactgtacca gaaactgaga tcctgagaaa tttgaaaata 181441 aatcgacatg gccgctgata agctgctgag cagcatgctt gtgactgtgc cgatgatggc 181501 gagctgcacg ggggtaaatc cgtttggcat catggcggca aggccgaata ctaacaccgc 181561 tcctaacgct gagccgataa aagagtatat catcatttca atcgaagatg attgcgggag 181621 cagaaccatg caaagcgtaa tgataaacgc tgaaccatct gaaacaccca taatggatgg 181681 cgaagctaaa taattgcgcg taatgccctg cataagcgct ccagaaacag caagggctgc 181741 ccctatgagc agagcgccgg cagcccttgg aatccgggaa tgccatataa tttgatggtc 181801 tgtgtttccc ggatcgaaat gaataagaga tgtaaaaaca atatctgtgc tgagatgctt 181861 tgccccataa aggattgaaa gcaaaagtga cagcgctata gcaaatggag aagtaatcaa 181921 tatgatacgt gtccactgtt ttgaatacat acaaaaacct actctgaatt agttttgtgt 181981 caatttttca gcagccgctt tcaggaaacg gactttgctc caagctgtgc cgccttgtgc 182041 gagagggtcc actgagttga catacacatg gtcttctttg actgctttaa ggcttttcca 182101 gattggattt ttctctaaat cttttaaggc atcaggtttg tctgcatttt catcatcaga 182161 aaattggacg aaaatatggt ccgggttcat ttcacttaat ttttctaatg aactcagctc 182221 ttgcgctttt gcagccttta cttcgttcgg cgccttaagg cctaaatcac cgtatagtgt 182281 ggagttgaaa tacacctgtt cagggtaaat gtaaatgttg ccttgtctga ttctgatgac 182341 aagcgctttt gaatctttcg ctttatcgtt gatttttgtt tttatttctt ttagatcctg 182401 ttcatagtct gcaataattt tctttgcttt tttctctttt ccagtcagct gggcaagaag 182461 catcatgttt tccttccagt ttgaagagat atgagaaact gggatcgtcg tgcctgctgt 182521 gctgattttt tgcagcgttt tttccggaaa ctttgttgaa gcaaggataa catctggctt 182581 catttcaaga atcttttcaa tatttggctc cattttttct ccggttggtt cggctttatc 182641 agtgatgtct ttgaacatat cagggaattt gccggagaat gaaattgcgc cttgcggatg 182701 aacgtcaagc aatttcgcgt cttccattga ttcaacgctt cccgtaatgg caattttgtc 182761 tgtcggtaca gttacttcat atgttttatc aaggtattca attttcttct tctcagatgc 182821 tgtgccgctt gccttgctgg cagttgattc atttttgctg ccgcaagctg ccgccgtcag 182881 cgcgagaagt aagattaata aggtaagaga tatctttttc atctatagag cctcctgttc 182941 aattgataac tattatcaat tggaattata gagaatgaac agatataaca ccatggacaa 183001 attcctgatt tatcatggac aatctccgga tagtaaagaa acagtttgct gaacgatgcg 183061 ttcgtgcccg caagctgagt attcattcca cgggtcaagg gatagaagat aaacacggtt 183121 atctcgtacc gcgcttaggt tttgccatgc ttctgtctgc tgtaattgct ggtagtaagc 183181 tatggtctcc ggctctttaa aaagaaaaag catcatacag tcagcttggt aatttgcgat 183241 attttctaac gaaatcgctt gttctgaagg tgtgtcagcc gttgttgccg agctgaatcc 183301 taaatcccca aagaaaactt cgcggacact tcggttatga gccagataga agttttgctt 183361 atgcagcctc aaaaagagaa aacgcagccc ttgaacgtgc tgaagtgttt ttttggcggc 183421 cgttgtctgc tggtcataat ccgctagcca cttttctgct tcggactcct cctttaaaaa 183481 tgaggcagtt tgcagaaagt gggttctcca gctttcttct gaaggaaggt acatgacttc 183541 tgcgatgcga ttcaggcgat cttgttcttc tggagaaata gaatccatgc tgacaatcac 183601 atctggttct gcctgtgata acgtgtacag gttttcttcc cacttttcat taaaccggta 183661 tgcactgagc tggacgggta tatctgtcga ataatgctga tagtagtaag acgtccattt 183721 cggatgcaga gcggccgcaa aaggtatgtg gtgaagaggg atgagatggc ccattgtgcc 183781 ccttccgtat gcggcgattt tctttcggcg ttttttcata tagcttgtag gtgaacagcc 183841 tgtatatttt ttaaagattc tgctgaaata aaattcatct tgataaccgg tttggtgtgc 183901 gatttctttc aatttgcagt ttgattttgc catgagccgt tttgcctttg tgattcgtgt 183961 tttcgtaata aattctgtta cgctctgtcc tgtccatttt ttaaagcttt cactgtagtg 184021 tttggcactg attcctgcca tttgcgacag ctgggcaagc gtgatttttg tatcggcatg 184081 ggtttcgata tagtgttttg ttttttcgat tgctgaatgt gtatccgttt gatcagataa 184141 actggcagta aaaagatcat aaatcaggct ttgtacttca atcacacatt ttagctgaga 184201 aagctgagac gattcattcc atagtgcggc aagctcttga agccggactg caagattttc 184261 gatatgtgaa acattcataa gcttcagttt ggctaattcc gattctgtgc acggtgtgaa 184321 aatatcttgc ccggtttcct tgatatagct tagaagcctg attatacagg catctatatg 184381 tccatcggct gctggcgtaa agccaaaggt ctcgttaggc ggacaaacat aaagtgtctt 184441 tttttgcaga ggattggtgt ttgttccgat cgaaatatag ccgtttcctt ttaaatgaaa 184501 aatcagcacg aatgaatcgg ctaattgctg ttctgagaag agatcacttg tcttttttag 184561 atattcaatt tgtactggtt gataaatcac tgcattttgc acgagtagac caccttttca 184621 gaagctttca attgataatc attttcaata aaaattgtac caaataaatg aaagttttcc 184681 tatataaagc gggtgggttt ttagcatgaa aaaaaccctt acttatgtgt aaaagtaagg 184741 gtctttcgtt caataagaat atgttacacg tgtaacatac gatgcttatg ttctaataaa 184801 tgagatactt ttttcttgtt ttgctgaatt gttggagtgt tttttcatag ctgtttatga 184861 tgttctcaac cgaagttcca ttttcaattt ttgtcctgat ccagccgttg cctgccagtt 184921 tatcgaatga acctgttgac aggaactcaa aatcctcagg atagagatcg tgtatggttt 184981 taatgactga aagacccgtt ttaacggctt caaacttatc tctgtctgtc acatagagct 185041 gcacaccgtg gcaaagcgtt ccttgatgtt tagaaaacgt cggtgtgaag gatgctgccc 185101 taaatgtaac gcccggcaaa tggaggctgt ttaatgtttc ttcaagttct gtgcttttga 185161 taaagggagc tccgatcaat tcgaatggct ttgttgtccc tcgcccttcg gatatatttg 185221 ttccttcaat cagcccggtt gcaggataaa caaatgtgct ttccaccgtc ggcatgttag 185281 gcgaagggag gacgaaaggc aatcgggtat cgtcaaaatc catttttcgt ttccagtgtt 185341 tcatttttac cactgtaaga tcggcatcaa tactaaattc tttgttgaac agtgaagcca 185401 attcgcctat cgtcatccca tgcttcaatg gaatgggata caatccgaca aatgaggcgt 185461 attcaggttc taagattggt ccttcaatat gattcccgcc ttgaggattc ggacggtcca 185521 gcaccataaa tggaatgccg ttttctttag cggcttccat tgcgtatgcc attgtataaa 185581 tgtacgtgta gaaacgggtc ccgacatcct gaatgtcaaa cattagaata tcgacatttt 185641 taagcatttc tggagtcggt tttttcgttt ttccgtagag gctgtatacg ggaaccccgg 185701 ttttttcgtc aatgtaagag cctacttcgt ctccagcctg ggcgtcaccg cggacgccgt 185761 gttcagggcc gaataaagct gtcagtttga tatccgggtt ctcgtaaagg atatcgacac 185821 tgctttttag agatgtgttt actccggctg gattggtgat cagtccgatg cgttttccct 185881 tgagctgttt tttatagtct ggcaagagcg tgtctatccc agtctggact ttaggttttt 185941 tagctgtttg attctttgaa tcgggtgaag cagaggcagc ggttatcgtt ccgaacatca 186001 tgagccctgt cagaaaagcg aatattgttt ttctcatgtg tccctcctta ttaaagcggt 186061 cttcccgttt tgatatttaa tccgtagcca agtgggtaaa gggtgttccc tggtttcgtg 186121 actgacggaa tgtcaactgg aagtgtgcct ttaggttttg cctggccgaa tatcgccatc 186181 actccggccg gaatattagg ttgaagataa cggccatttg cgtatccttt aaagccatag 186241 actgcaatca gtgcttttgc ttcttcgaaa ttggctgcgt cataggggtt gcgcaggctc 186301 attaagacaa atggtttgtt gtgctgcagt gcggctttca tgacagctct cggaaacacg 186361 gtggcccatt tgcttgaatc tgatattgtg tcgtcgatga caccgtcgtt gacgacaggg 186421 tcatttttga cgacatagga gccggtaatg atataatcag cctcttttac ttgtttttca 186481 tgctcggtct taaatacttg gctggcaaag ttcattttgc tgagggatac gggtttgatt 186541 ttctttcgct tgatgagatc gtgaatggtt tgttcgattg aagcagtttg ttcttcgtaa 186601 ggtgccacaa ttaagattcg gctgcctttt ttaggcttga acggcaaagt gtgctgttca 186661 ttttttaata cagttactgc tttttcagct aattttttct ctgctttcag gtgctgcttg 186721 cttcctacga tttttttggc tttggctatt ttttcttttg tactgtcgct gtttcgcgct 186781 ggatacatgc cgcgttttat tttcagggaa atgattcttt caactgaatt gttgatttgt 186841 tgttcaggaa tatccccgtt tttcacggct tctttcaaag cttgaataac acgtgcgaat 186901 ttctgttctt ctttcaatga agtgactgag gctggcatta atgcaatatc gacaccagct 186961 tttacggcca tgaccacagc ctcttcctgt ccgaaatgat ctgcgattgc cttcatattg 187021 agcgcatcgg taacgatgac cccattaaag cccatttcct gacgaagaag acctgtcatc 187081 actttttttg aaagtgtagc tggaaccaga atgtccgatc catcgagttt gcttttgtaa 187141 gtggtgtcat caaaggcggg aaactgaaca tgggctgtca tcaccatatc agcaccagca 187201 tcaattgctt tttgaaaagg ataaagctcg acctcacgaa gccgttcttg gccatgggaa 187261 acgagcggca gtccataatg gctgtcaacg tccgtgtctc catgtcccgg gaaatgtttg 187321 agggcagacg cgatatcctg ccgctgcaac cctttcatcg tatataaacc gaggcgtgat 187381 gtcagttctc gattggagct gaatgaccgt acgccgatta caggattatc aggattattg 187441 ttaatgtcca cgacagggct gaaatctgta ttgatgccta aggcagagag ctcttttccg 187501 atgatgctgc cggtctgata cgcattgatt ctgcttctgg ctgcgcccag cgccatattc 187561 cctgggaaat tagtgccctc ccctaacctc gttacaatgc cgccttcctg atcaatactc 187621 agcatgagcg ggatttttgg acttgccttt tggtaatcgt ctgtcagttg gacagtttgt 187681 tttgttgttt ttacattttc tgcaaaaagg atgatgcctc cgaattgata tttcttgacg 187741 aggctggcga cttcatcatt catttttgta agggcttgcg gagaggactc gccttccttt 187801 tgccaatttc taaaatcagg catcagcatc tggccgagtt tttcatctaa cgacatacga 187861 ttgacaatct gattggcatc gattgcacgt ttggatgcag aggcttctgt ctgtctggcc 187921 ccgaaaaagc atgaaagaaa gagaacggct gaaaggataa gcggaaagac aggtctcata 187981 gaaacttcct cctatcgtct aatcattcac tccatcgctt cataaatcgc ggttatgaca 188041 cttccataac tgcctgttgg aaattggtca ccttcaaaga cgttcggatt ttcttccgga 188101 tcaataactg gtgtatgctt tttatttgtt aacaatgcga tgcctaaatt gtatgctgga 188161 tcaataattg taactgtccc cgtccagccg gtatgcccgt aagcattttc gctggcatga 188221 gggccaaaca tccattccat gcttttactt ccgttccgcc tccagccaag agcgaatgtc 188281 ggatctgttg ctgaaggtgc tgtaaacagg tcggctgttt tctgatcaaa taaagaaatg 188341 tttcggtatg aacctttgtt taacatgact tgcagcagta tggccatatc atctgcattt 188401 gagaacaatc cggcatgccc agacacgccg tccattgagt aaaacgcttt ttcgtcatgc 188461 acctctcctt gcagcgtgtt tgtgcggatg ttagggaatt gaataacgcc gtcacgtgta 188521 ttgcccatgc gttcagtagc tgcgaactgt ttcggtttaa agcccttttg cagcggattg 188581 tacaaggtat gcttcagcct gagcggtttg tagagctctt gctccgtgta gacatcaagc 188641 ggtttgccgg tgagtttttc gacaatacat ccgagtagca tatatccaat gtcactgtat 188701 acgtgttttg tcccggtttg ataatcgagc ggaattttcg tcaaatattc aatcgttttg 188761 tcccgttctt gggaatagta cttgccggct ttttccggcg tgtaaaagta aaagcttgat 188821 gggagccctg attggtgctg gaggacatca atgacacgta tcttgtcttt tccttttatg 188881 aggtcacccg gctgatcctt gaaacccggc aaatatgcag aaactttttc atagacgtca 188941 agttttcctt ggctgactaa gcgctgcaat gcaaaatttg ttgcgtacat ttttgtattt 189001 gaggctaagt caaacatcgt gcgggttttc attttggccg gacggcgcag cagttctgat 189061 ccttcgtact ttttactgta gccgtatgct gcttttttta tgatgcgtcc atccttcacc 189121 accacaagaa cggcgcctgg aaatcctgct gcaatatccc gttctatcat ctgatctacc 189181 ttccttagct tcttcgtcga gaattgtgca gtttctgcat ttatgatttt cggctcaatc 189241 aagttgcctg ctgtttgtgc gaaggtttca tttggcgcaa atatcgatag ggttaaaatg 189301 gcactgaata tgaacagtgt ctttgttttc acaggctagc ccctttctgt gcttctatcc 189361 cgtttactat ccctaaaaca gaaacaattt aatcgaactg agaagccatt tcatctttat 189421 atccgaatgc ataggtcaat aaaaaaccgg ccgcgtagga aataaagagc ccaacgatat 189481 acaggatgat ttgcgaaggc aggactagaa aagatagcgg cagtccggag acaccaatcg 189541 caatggtggc tacttgaaaa taagcttgaa aggcgccgcc gattccagct cctaaacatg 189601 ctgttaaaaa cggacggcca agcggcagcg tgactccgaa aataagcggt tcaccaatgc 189661 cgagcagtcc cgatggaagc ccgccggcga ttgctttcct cagtgttgtt tttttcgtct 189721 tcacgaaaac ggcaaaggcc gcgcctacct gtcctgcacc tcccatagcc aaaataggga 189781 gcagaggatc attgccaatt gaattgatca gttccatgtg cacaggcgtc aagccttgat 189841 gcagtccggt tacgacgaga ggaaggaagg ttgcgcccag aataaagccc gcagcgatgc 189901 cgccgatgtc caggatggac agtaggccgg atgtaatagc atcagaaatg aatccgccta 189961 aaggcataaa tacgacatac gttacgattc cggtgattaa cagtgaaacg gtgggtgtga 190021 caatgatatc aagtgattga ggaataaaac ggcgaataaa ttgttcggtg taagcaatga 190081 atatggctgc gaaaaggacg ccgatcagac ctcccctgcc cgggagaagc tcttctccaa 190141 ataaactgat ttttgcgatc tccggattga taatcaagat cccggccaaa gccccaagtg 190201 cgggtgtccc gccaaattct ttcgaagcgt taataccgac gagaatgccg agataagtga 190261 acagccctga tccgatgact gtcaggataa tcgcaatttg tgagtctgca gagagccagc 190321 ctgcttgaat aattgctttg gtaatcccag taattaaacc ggaagcgact agagcgggaa 190381 taagagggat aaaaatgctg gcaattttac gtaagaaaag tttaaaagga gtggcatttt 190441 tccgattgat atcggctttc tttttggccg ctgcttcttt gacatcggca ccttcttctg 190501 ctgacacgag ctttgagaaa gcagctgtaa catgattgac aactcctgtg ccgaggataa 190561 tttgtaaggt ttcagcttca acgaccccca atacgccgtc aagctttctt aaagcctgag 190621 catccgcttt gctttcatcg taaggcgtaa tgcgcaggcg tgtcatgcaa tgcgtatatg 190681 aagaaatatt ggattttcct ccgcatagct caaggatttt ctgtgcgaga tgatggtagt 190741 tattttcttt gctcattaaa acccctcccc ttcaagatgc cttattttat tctcatagat 190801 tgtatggctg ctctcgtttt atctatataa ccggttgtcg tttcatactg ctcagccgcc 190861 atgcctaaaa acaaaacatc aattataaaa agctgggcga ggcgggaaga agtggctgca 190921 cttcgaatca aggcttcatt ggaatgggct gtatacaaag ggacatcagc cagtgcggag 190981 acggatgtct gactgaattg tgtgaggctg atcgttgtga tgcctttttc cttagccatg 191041 gcgaacagtt caacgatttc ctgtgtctct cctgaaaacg aaatggcgaa tacgatgtcg 191101 tctttatctg catttgcgat taaagatgcc acaagatgag tgtctgtaaa cgcggttgct 191161 tgtttatgaa tgcgaagcca cttttgctgg gcgtccttgg cgacaatgcc ggaagccccg 191221 aggccgataa aatgcacggt atgagctttg agaagcagag aaaccgctcg ttcaagctct 191281 ttgtagtcca tcaggtctga agtatcctga atggcttgaa tggcattgcc ggccgttttt 191341 tcggaaatgg agggcagcgg ctcgtgggga acaatatccc ggtagccctg aaacgtaggc 191401 tttgccagat cgcctgctac tctcattttt aaatcttgaa atccttttaa accgagtgat 191461 ttgcagagcc tgatgacggc agcgtcactt gaattggcta aggcgctgat ttcgttgacc 191521 gtgctttcga ttgctttgtg gggatgggct aggatataat ctgcaagttt gcgctcggat 191581 ggagggagct tatgcttcat tgattggatg atcgctaaac cgcctgtggc cattctagtt 191641 ctctccttat catggatggt aatgttcgat tgctttgtca atgaaaccgt ttgcttcatc 191701 gagtaatgtc tgtgcttgtt tctgatctgt gcttgttttg agcatgacga ttgctgtttt 191761 gacgtgatga tcggcttgtt ccagagtgta tctggctgtg tcgtatgaag cgtttgtaag 191821 gctttggatg atgctgatgg cgcgttcttt tagttttttg ttgctgacgt tgacgtctac 191881 catcaagttt tcgtaaacct tgccgatttt gaccattaca gcggtagata tcatgtttag 191941 aatcatttta tgagcggttg cggctttcat acgtgttgat cctgtaatgg cctcaggtcc 192001 gacgacaacc tcaatgctgt gatccgcatc cttgctgatg gcggaatttt cattgcaagt 192061 aagggcgatg gtgtgtgctc cgactttacg ggcgtatctt agggcgcctg cggcgtaggg 192121 tgtgcggccg cttgctgcga tggcaatgac ggtgtcattt gaagtgagct gtatgtttct 192181 taaatcttca gctcctgctt cttcactgtc ttcaatgccc tctgctgcct gtaaaaaggc 192241 ttcggggcct ccagccatga ttccgatgac ctgatctggg cttacgctgt aggtgggagg 192301 acattcaaca gcatccatga cgccgagtct gccgcttgtg ccggcgcctg tatatatgag 192361 ccggcctcca ttttgaaacg attcatatgc gcagtctaca gctgttttga tgtcggggag 192421 aacctcctga acggctgcag cgactttcat atcttcgttg ttgatcattt taaggatgcc 192481 gagagtgttt gctttgtgga tttcaactgt ttgactattg cgtgattccg ttgtaagacg 192541 gtgaaggttt aatggttctg acatgaggat gccccctgtt ttaaaatgat atatctcaat 192601 attcagtata ttcatttctg ttatgatatt tcaactatgt ttttaaattt ttgaaatttt 192661 atttcactta agactataag aaatgatgaa ggatcaactg ttctccaagc ggcccgattc 192721 ttcgccgtcc tttatcaagg aacccgcttt tcatataaag gtgttttgcg cgtatgttca 192781 gatgattgac ggccaagatg atttcgtcgc accatggaaa atatccgctc acaaaagcgg 192841 gaagcaaaag catggctttt ttcgcatagc cttttccgtg atgcacagcg gttaaagaca 192901 gggagctgag cagtaaagca aatggattgt tagaatagga agcaagcgtt tcttttgatg 192961 catgtaaaat gaaaaaaccg actggaaggt cgtcttttaa gatgacaacc gggtatcggt 193021 cctgtatgcc cagagcctga gacagcacct ctttcgggag ggaggtaaag cgtttgtcat 193081 cgttggtgag cgtgaatgat tggagctcgg gcaagtgttc aggcttatag aaggataaag 193141 aaatgtcttg agtcatgggg tggcctcctt acaatatgtc gttaagctcg ttttccgaaa 193201 tgacgcggta gcccgcttgt tttaacagtg cggcggttac tccgctgccg gtgatttttt 193261 tgccagagaa tgtgccgtta tagataaaac cgcttccgca agatggactg ttttctttta 193321 atatgacggc agaagcgttg atttcttttg cgtaagccaa tgttttcgcg gcgccttcca 193381 tatatagttc tgtgacgtct tctcctgaag ctgtcacgat tttcgctgtt ccattgagga 193441 catcctcgcc agtgcctcct atgatttctg cgggttcgcg tggggtagag aagccgccga 193501 gaagttcagg gcaagccatg actgctttct tttcatcgac tagttttctg attttctccg 193561 acgctgcgtg agagccgtta tatctgcatt caatgcctcc aaggcaagaa ctgactagaa 193621 tcatattggt ttctcctctc ttgctttgct tgtctctatc ataaaataaa tggctttagt 193681 tgggaggctt tttcagttaa aaaaggagtt aaaaagtttg aaaataaaaa atttaatttt 193741 cctctttaca aacagggggt gacctgtata taataacttt tgtcagctcg acgagaacac 193801 aacggcccgt tggtcaagcg gttaagacac cgccctttca cggcggtaac acgggttcga 193861 atcccgtacg ggtcaccatt tggaggatta gctcagctgg gagagcatct gccttacaag 193921 cagagggtcg gcggttcgag cccgtcatcc tccaccatct tgccggtgta gctcaattgg 193981 tagagcaact gacttgtaat cagtaggttg ggggttcaag tcctcttgcc ggcactgttt 194041 tttcaaaatt ttatgtggag gggtagcgaa gtggctaaac gcggcggact gtaaatccgc 194101 tccctcaggg ttcggcagtt cgaatctgcc cccctccacc attattgggc tatagccaag 194161 cggtaaggca acggactttg actccgtcat gcgttggttc gaatccagct agcccagtca 194221 cagacacctt tgatcaaaag gtgtcttttt tcttttcgga aaaatcattc caacttctaa 194281 ctgttcagtc tgtataataa ttttaaaaat atgttaaggt agtttattca cgaattacca 194341 tctacaccct gccaaaaatt tgataaactt attttataaa aaaattgaaa ccttttgaaa 194401 cgaagctcgt atacatacag accggtgaag gcagaggtta gataaatatg gaaatgatga 194461 ttaaaaaaag aattaaacaa gtcaaaaaag gcgaccagga tgcatttgcg gacatcgtag 194521 atatttacaa agataaaatt tatcagcttt gctaccgtat gcttggcaat gtgcatgagg 194581 cggaggatat tgcacaggaa gctttcatca gagcgtacgt taatatcgac agttttgata 194641 ttaaccggaa attttcaact tggctttatc gaatcgcgac caatttgacc attgaccgca 194701 ttcgcaaaaa gaagccggat tattacctcg acgcagaggt ggctggtacg gaaggcttga 194761 ccatgtattc tcaaatcgtc gcagatggtg ttttgcctga agatgcagtt gtatcgctgg 194821 agctctcaaa cacgatacag cagaaaattt taaagcttcc tgacaaatac agaacagtca 194881 tcgtattaaa gtatattgac gaactctcat taattgaaat cggggagatt ctaaacattc 194941 ctgtggggac tgtgaaaacg cggattcaca gaggcagaga ggctcttaga aaacaattaa 195001 gggatcttta agtggggtga tgaaatgagc tgtcctgaac aaattgtgca gcttatgcat 195061 atgcatcttg atggagatat ccttccaaaa gatgaacacg tattaaatga acatctggag 195121 acatgcgaga aatgcagaaa gcatttttac gagatggaga aatccatagc gctcgtacgg 195181 agcacatcgc atgtcgaagc ccccgcggat tttaccgcta atgtcatggc aaaattgcct 195241 aaggagaaga aaagagcttc tgtaaaaaga tggttcagaa cccatcccgt tatcgcagct 195301 gctgcggtat tcatcatttt gatgggcggg ggttttttta acagctggca taatgaccac 195361 aatttcagcg tgtccaagca gccgaatctt gtggttcata accatactgt gaccgtgcca 195421 gaaggtgaga cggtcaaagg tgatgtcact gtcaaaaacg gcaagctgat tattaaaggc 195481 aaaatagacg gggatgtaac cgtcgtaaac ggcgaaaagt atatggcctc tgctggacaa 195541 gtcaccggtc agattgaaga aatcaatcag ttattcgact ggacatggta caagatgaag 195601 tctgcgggga aaagtgtact cgatgcattc aatccgaacg gagaagagta aagcgcgtta 195661 gccgctttgc tctttttttg cgggctgaga gggctggcac atttcacttg ctaaatcgaa 195721 atgtggtata atgggctcgc tatgtaaagt acatatgcgt aacacgtaaa acacaaaata 195781 cgaaatgact gaaatcttgg aggacgagga aatggctttt gaggatatcc cttttttgca 195841 gtacctcggc aatgccgttg atattctcct tgtttggtat gtgatatata aattgattat 195901 ggtgatacgc ggcacgaaag cggttcagct gttaaaagga attgtagtca tcgtgcttgt 195961 tcgtatggcc agccaatatt tgggcctcag cacacttcaa tggctgatgg accaagcgat 196021 aacatgggga tttttagcaa ttattattat ttttcagcct gagctgagaa gagcgcttga 196081 acagctaggc cgcggccgct ttttttcgag gagcggcacg cctgttgaag aagcgcagca 196141 gaaaacgatt gaggccatta caaaagcaat caattatatg gcgaaacgcc gtataggcgc 196201 cctgctgacc attgagcggg atactggaat gggcgattat attgagaccg gcataccact 196261 aaatgccaaa gtcagctctg agctgctgat caatattttt attccaaaca ccccgcttca 196321 tgacggtgcg gtaattatga aaaataatga aattgccgcg gccgcctgtt atctgccgct 196381 ttctgagagc ccgtttattt caaaagaact gggcacgcgg cacagagcag ctgtcggtat 196441 cagtgaagta acagacagtt tgacgattat tgtgtctgaa gagaccggcg gcgtcagtgt 196501 ggcaaagaac ggcgaccttc acagagagct tacagaagaa gcgctgaaag aaatgcttga 196561 agccgagttt aagaaaaaca ccagagacac ttcttctaac cgctggtatt ggaggggcaa 196621 gaaaaatgga taaattctta aacaaccgct gggctgtgaa aattattgct ctgcttttcg 196681 cgctcttgct ttatgtggcg gttaacagca accaagcacc gactccaaaa aaaccgggtg 196741 aatctttctt tccgacatca acaactgatg aagcaactct gactgatatt ccggttaaag 196801 cgtattatga tgatgaaaat tacgtcgtga cgggtgttcc gcaaacggtt aatgtcacga 196861 taaaaggctc gacaagcgcc gtgaaaaagg ctcggcagac caaaaacttt gaaatatatg 196921 ccgatatgga acatttgaaa accggcacac ataaggttga gcttaaggcc aaaaacgtgt 196981 cggatgggct gacaatctca attaatccgt ctgttacgac agtgaccatt caggaacgga 197041 cgaccaaaag ttttcccgta gaagtggagt actacaacaa aagcaagatg aaaaaaggct 197101 attctccgga gcagccgatt gtcagtccga aaaatgtgca gattaccgga tcgaaaaatg 197161 tgatcgataa tatttctctt gtaaaagctt cagtgaattt ggaaaacgca gatgaaacga 197221 ttgaaaagga agcgaaagtg actgtctatg ataaagacgg aaacgcgctt cctgtcgacg 197281 tggagccctc ggtcatcaag attaccgttc cggtgacaag cccgagtaaa aaagtgccct 197341 ttaaaattga acggacagga agccttcctg acggtgtcag catagcgaat attgaatcca 197401 gccccagtga ggtaacggtt tacggctcac aggatgtgtt ggattctctt gaatttattg 197461 acggcgtcag cctagattta agtaaaatta acaaggattc cgatatcgag gcagatattc 197521 cgcttcctga cggtgtcaaa aaaatctcac cgtcaaaggt gactttgcat atagaagtcg 197581 atagtgaagc ggatcagaag ttcgagaatg tccctatcaa gactgtaggg ctgagcagct 197641 cacaaaacat tgaatttctt gatcctgaat cacaagcgat agatgtaacg gctaaaggct 197701 ctcccacgaa tataaataaa ctgaaaaaat cagatattga attgtatgtg aatgtttcag 197761 atttagagga cggggagcat agcgtgaagc ttgaagtgaa cgggccacag aatgtaactt 197821 ggtccttggg gcggaaaaac gccaaaatca agctgacgtc taagaaaagc aatacatcaa 197881 cgaatgataa cagcagcaat acatcaggga accaggacac agataaacaa acaaatgatc 197941 aaaagaacaa tcagcaagaa gatacaaaga acactgataa aaacaacaac gatcaaaacc 198001 aagacggaaa taaagatcaa aaccaagatc aggatgagga tgaatccact gcgaattcac 198061 aatcctcatc ggaataaaaa aggagcgatt ataaaatggg caagtatttt ggaacagacg 198121 gtgtaagagg tgtcgccaat agtgagctta cacctgagct ggcctttaaa gtcggacgtt 198181 tcggcggtta tgtgctgaca aaagacaaac aacgtccaaa agtgctgata ggccgcgata 198241 cacgcatctc cggccatatg ctggagggag cccttgtcgc cggactttta tccattggcg 198301 cagaagtcat gcgcctgggt gtcatttcta caccaggtgt atcttatttg acaaaagcga 198361 tggatgcaga ggcgggcgtc atgatttccg cttctcataa cccagtgcag gataacggca 198421 tcaaattctt tgggggagat ggatttaagc tttctgatga acaggaggct gaaattgagc 198481 gcctgatgga cgaacctgag gataagctgc caagacctgt cggagcagac cttggacttg 198541 taaacgatta ttttgaaggc ggacaaaaat atctgcaatt cttaaaacag acagctgatg 198601 aagatttcac aggcattcat gtggcattgg actgtgccaa tggcgcaacg tcatccttgg 198661 cgacacacct gtttgctgat ttagatgcag atgtttctac aatggggact tccccgaacg 198721 gattaaacat taatgacggc gtcggttcga ctcatcccga agcgctcagc gcgtttgtca 198781 aagagaaaaa cgcggatctc ggtcttgcgt tcgacggtga cggcgaccgc ctgattgctg 198841 tcgatgaaaa aggaaatatt gtagacggcg accaaatcat gtacatatgc tcaaaacatc 198901 tgaaatcaga gggccgttta aaggatgata cagtggtttc aaccgtgatg agcaacctcg 198961 gcttctataa ggcgctcgaa aaagaaggca tcaaaagcgt gcagacagct gtcggcgacc 199021 gctacgtagt agaagcaatg aaaaaagacg gctacaacgt cggcggagag cagtcaggac 199081 atcttatttt ccttgattac aacacgacag gggacggatt attgtctgct attatgctga 199141 tgaacacttt aaaagcaaca ggcaagccgc tgtcagagct tgcagctgaa atgcagaagt 199201 tcccgcagct gttagtcaat gtgagagtga ctgataaata taaagttgaa gaaaatgaaa 199261 aagtaaaagc agttatttct gaagttgaaa aagaaatgaa cggcgacggc cggattttgg 199321 tgcgcccttc aggaactgaa ccgctcgtcc gtgtcatggc tgaagcgaag acgaaagagc 199381 tgtgcgatga gtatgtcaat cgcattgttg aagtcgtccg gtcagaaatg ggattagagt 199441 aacgaagtct attatcagag agtgaacaag acaagcgagg tttacataag ataattgtga 199501 gacatacggc aaagttgctt aaaaaacaat tgaccgttta tgccacatgt tgtaaaatca 199561 agcttgtctt gttcttattt tctcaatagg aaaagaagac gggattattg ctttacctat 199621 aattatagcg cccgaactaa gcgcccggaa aaaggcttag ttgacgagga tggaggttat 199681 cgaattttcg gcggatgcct cccggctgag tgtgcagatc acagccgtaa ggatttcttc 199741 aaaccaaggg ggtgactcct tgaacaaaga gaaatcacat gatcttccaa aaaacatgta 199801 ggaggggacg attgaaagtc cccttgaaat ttgactttct tcgtctcctt ttacaatctt 199861 aggaggaaga aaaatatgtg tggaatcgta ggttatatcg gtcagcttga tgcgaaggaa 199921 attttattaa aagggttaga gaagcttgag tatcgcggtt atgactctgc tggtattgct 199981 gttgccaacg aacagggaat ccatgtgttc aaagaaaaag gacgcattgc agatcttcgt 200041 gaagttgtgg atgccaatgt agaagcgaaa gccggaattg ggcatactcg ctgggcgaca 200101 cacggcgaac caagctatct gaacgctcac ccgcatcaaa gcgcactggg ccgctttaca 200161 cttgttcaca acggcgtgat cgagaactat gttcagctga agcaagagta tttgcaagat 200221 gtagagctca aaagtgacac cgatacagaa gtagtcgttc aagtaatcga gcaattcgtc 200281 aatggaggac ttgagacaga agaagcgttc cgcaaaacac ttacactgtt aaaaggctct 200341 tatgcaattg ctttattcga taacgacaac agagaaacga tttttgtagc gaaaaacaaa 200401 agccctctat tagtaggtct tggagataca ttcaacgtcg tagcatctga tgcgatggcg 200461 atgcttcaag taaccaacga atacgtagag ctgatggata aagaaatggt tatcgtcact 200521 gatgaccaag ttgtcatcaa aaaccttgat ggtgacgtga ttacacgtgc gtcttatatt 200581 gctgagcttg atgccagtga tatcgaaaaa ggcacgtacc ctcactacat gttgaaagaa 200641 acggatgagc agcctgttgt tatgcgcaaa atcatccaaa cgtatcaaga tgaaaacggc 200701 aagctgtctg tgcctggcga tatcgctgcc gctgtagcgg aagcggaccg catctatatc 200761 attggctgcg gaacaagcta ccatgcagga cttgtcggta aacaatatat tgaaatgtgg 200821 gcaaacgtgc cggttgaagt gcatgtagcg agtgaattct cctacaacat gccgcttctg 200881 tctaagaaac cgctcttcat tttcctttct caaagcggag aaacagcaga cagccgcgcg 200941 gtactcgttc aagtcaaagc gctcggacac aaagccctga caatcacaaa cgtacctgga 201001 tcaacgcttt ctcgtgaagc tgactataca ttgctgcttc atgcaggccc tgagatcgct 201061 gttgcgtcaa cgaaagcata cactgcacaa atcgcagttc tggcggttct tgcttctgtg 201121 gctgctgaca aaaatggcat caatatcgga tttgacctcg tcaaagaact cggtatcgct 201181 gcaaacgcaa tggaagctct atgcgaccag aaagacgaaa tggaaatgat cgctcgtgaa 201241 tacctgactg tatccagaaa tgctttcttc atcggacgcg gccttgacta cttcgtatgt 201301 gtcgaaggcg cactgaagct gaaagagatt tcttacatcc aggcagaagg ttttgccggc 201361 ggtgagctaa agcacggaac gattgccttg atcgaacaag gaacaccagt attcgcactg 201421 gcaactcaag agcatgtaaa cctaagcatc cgcggaaacg tcaaagaagt tgctgctcgc 201481 ggagcaaaca catgcatcat ctcactgaaa ggcctagacg atgcggatga cagattcgta 201541 ttgccggaag taaacccagc gcttgctccg ttggtatctg ttgttccatt gcagctgatc 201601 gcttactatg ctgcactgca tcgcggctgt gatgtggata aacctcgtaa ccttgcgaag 201661 agtgttactg tggagtaata attaattaac ccctttggat aagaaggtct tcacatgtgc 201721 tgctaggctc caaatgtaca cctttccgta agggcaaagt caaatgtgaa aaaaaactgt 201781 tccaaagtta atcagaaatt tattttcata ttgtatcctt cggtatcaag tgaaaggagc 201841 atcatatgaa aacattatgg aaagtcctca aaattgtttt tgtcagcttg gctgctttgg 201901 ttttgcttgt atccgtctcg gtatttattt atcaccattt ccagctaaat aaggaggcgg 201961 cactgctgaa aggtaaaggc acagtagtcg atgttgacgg taaaaagatg aatgtgtatc 202021 aagagggaag cgggaaggat acgtttgtgt ttatgtccgg ttcgggtatt gctgcgcctg 202081 cttatgaaat gaaggggctg tacagcaagt tttcaaaaga aaataagatt gctgttgtag 202141 atcgggcagg ttatggatac agtgaagtgt ctcacgatga cagagatatt gatacggtat 202201 tggaacagac gaggaaagcg cttatgaaaa gcggaaataa gcctccttat attttaatgc 202261 ctcattcgat atccgggatt gaagcgatgt attgggcaca gaaatatcct aaggaaatca 202321 aggccattat tgcgatggat attggattgc cccagcagta cgtcacgtat aaattgagcg 202381 gagttgaccg attgaaagtg agagggttcc acctgttaac ctcgattggt tttcatcggt 202441 ttataccttc cgctgtatat aatcctgagg tgattcgaca gtcgttttta actgatgaag 202501 aaaaagaaat ctataaagcc attaacttta agcaattttt taatgcagat atggagcatg 202561 agcttttaca gtcttaccaa aacggcagca aatctgtgaa tctgcctgcg ccaaaggaaa 202621 ctcccgtctt gattttagat gcagtctctg accaaaatag acattcaaag tatgctatac 202681 aaaaccgaaa agactatgaa gcgtttgcgg ctcaattcaa tactgccgat ataaaggaac 202741 tgaggggaac acacagtatt tatttatatc agcctgatca aatatataaa ctgtccatgg 202801 agtttatgag aaaggttcgc taggatgaag ggttatcgta ttttaatcgt tgaggacgat 202861 gtgatgattg gtgatttgct gcaaaagatt ttgcagcgcg agggatatcg tgtgatatgg 202921 aaaacagatg gagcggatgt gctttcggtg attcagaagg tggatttggt cattatggat 202981 gtgatgctgc cgggtgaaga cgggtatcaa atgtctgcaa aaatcaaaaa gctggggctg 203041 ggcattccgg ttatttttct ctcagcccgc aatgacatgg acagcaagct tcaaggtttg 203101 cagatcggcg aggattatat ggtaaagccc tttgatccga gagagctgct attaagaatg 203161 cggaatatgc ttgagcatca ttatgggacc tttacgcaaa tcaaacattt gtatattgat 203221 gcggtaacga aaaaagtgtt caatgaaagc ctgcatgatg aggtattatt tactgcgatt 203281 gagcggaaaa ttttctttta tttatatgaa aatagagaca gtatcctgac aaaggaacat 203341 ttctttgaat atctatggca gctcgaagat agaaacccga atattgtcaa tgtgcatatt 203401 aaaaaaatta gagctaaaat caatgatcaa gcgggtgaga tgattgaaaa tatatatgga 203461 gaagggtatc ggctgaatac cgttgtgaag aaatgaagct caagacaaaa tatcagttgt 203521 tattgtttac ggccgtcatt agtgttccga tgctattgct ggcggtcagt gttttgatgt 203581 cggtgattta tgacagcatg tttaaaccga tgaatcatgg tatgcccttt cacaggtcgt 203641 ttgcataccc ggcaatgatc gttgtatttt tgatatcact cttattgtta gcttttttat 203701 tttcaaagtc gattcattct ctgttgcata aaatcaatct attaaatcaa accattcggc 203761 atttggcgag tgatcaaagg gtgcccgata aaattgaagt gaagcgtgct gatgaaatcg 203821 gggaactgat caagtcggtc aatttgttaa ttgaacggac gacatatcgt gaactggagc 203881 tgagacagca ggaggaaatc aaaaaggagc ttttgcaaaa actgcggcat gacattaata 203941 cacctttaac ggctctcagg ctgcagttat tttatttgga agaccaatgt catggtcagg 204001 ctgtattcga atcattgtat cagcaaatcg aatatatctc ggaattaact aatgaattca 204061 atctatattc cgctgagacg ctggaaagct cttatattgt aaatgaagaa gtgcgtctaa 204121 acgagctatt agaaacagcg gtgaaaaagt gggattattt atacagtatg agtgggattg 204181 agctgcacta taagccggca gatcaagatg tgatatggat gagcaacacg ttatggatgg 204241 aaaggctgtt tgataatatt tttcaaaata cgttaaggca ttcaaaagct aaaaagatgg 204301 aagtcacgat tgaacatggc gatgttttta ttcgtgatga cggtattgga tttgatcgga 204361 atgagagcag tgagggactt gggttaaaga ttattgagga tacatgcagg ctgcttgcga 204421 ttacttatga gctgcataca aatgataacg gaacggggtt cttgttttca aaagagtgac 204481 cccgctgatg tttttctttc tcctataaaa tttatataat agggagaaag aaatggggtg 204541 aacatcatat gtttaaaaaa atcatcaaaa cgattaagta cctctcaagc agttctagtg 204601 accgatatcg cagacaccgg cattacagca gcagccggcg cagacattat cgcagctaca 204661 gcagcagttc gggcaaaaga agacactacg accgttatgg cggcagtcat cgttacaaac 204721 gccggagcta cagcagcagt taatccaaaa aaagttcttg ttccgctttt gggacaaggg 204781 tttttttatg tgaccgattg aatggcccgg tttagatcct cgcgaatgga agcggtgtgc 204841 tgatactctt cctcaatgcc caataatctt ttcagcagca aggttacttc ctttgtcagt 204901 gttaattcct ccagccaagt gccgtttttc ttcttttttc ctttatattg agagtacagc 204961 aagaataaca gcgtttctcc gagatcgaag aagtcatcct gttttcgtac ctttatttcc 205021 tccatttctt caggagtcaa ttgtttggca aggccgaaat cgatgaggca gagcctgcca 205081 tcattgatga tgatattagg cgttctgatg tcgctgtgga agataaggcg atcatgcagg 205141 tattctataa tctcaagcag ctgcgaaatc agttgtaacg ccataagctc tgtgaacggc 205201 tgttttcgaa aaaataataa ttcttctata ttctctccct caatgaactg catgacataa 205261 taagcctgtc cgtctatgat gaattcatct atgaagcccg gaatttgcgg gtggtgaatg 205321 tttttgagca gttttatttc ctgctggaat cggactttct ctttttcctt tttggctttt 205381 gtcggccgaa gctgttttaa gacataaggt gtttgagcta ggatatcggt gcacaaataa 205441 accaaaccgt agcctcccat accgaggcac tcttcgattt tgtattgatg atttaagata 205501 acgccgttct ttagagggcg gtcaaatagc agttttttta gaagttttaa tgccatgtct 205561 gcacttccct tggttgtact gactatagtt taccttctag acggagaata aaaaagagcc 205621 ggataaccgg ctcggtataa gttaaaactg ctttgtcacg tcgtattcat aatctatttt 205681 tgcttttacg ttgctcatcg tcgatctggc tgtcgctaat gtattatatt taaaactcca 205741 tacctttgcc acactgagtt gatccgacaa agagatatca taagaccctg aagtcgagct 205801 gtttacaagg gcacggctcc attcgttatt ttcgcttgtc atgatcagat ggcgtgtatt 205861 tccctggctt ggtgtttgag tggcggttgt ttgaactctg gttacaatgg catcacgcgg 205921 tatcccagat tggtttgtta aatcaacctt gatcacgctg gagtcagaac ctgaggggct 205981 aaggcttgta tttcctttat tttcagcaac gccgctgaat tggaacgttc cgctgcctga 206041 tttgattcgg tcttcaattg aaagcgtaaa gtacatgttt ccagtatagg tgcctcgtga 206101 cactttcaca tagaaggtat ccgtcgtgtt ttgggcgtct gcatttgcat aaataaaaga 206161 agaaaacgta ttagggttaa taacttctgt cccttgagaa acaggtattc tgttcttgtc 206221 ataaatttca attttcatcc ctgtatacgc gctctggtat gtactcctca tgtatacttt 206281 ttctccctta ttagccgtaa aagtgaaata ggcttcatct tgaccagctt ccagtattgt 206341 tgtatcgata tttttatatt tccaataacc gatcggcatt gcggtatcaa atgaattgtt 206401 tcctgtgata gcagtgactc cgacagctga tgccgaatac gtaaaggtag ataagacaga 206461 aagcataaca gcgaattgaa taagccattt tttcaccatg caaacaacct ccttttattt 206521 ccatcataca taataacgat ttaggtgtaa ataaatgttt tttgaggtta atatatacat 206581 tatattcgcc gataaaaaag aataagagag aatactcggg agggaattca atgcgtctga 206641 atcggcaatt tatccgcact cagctgattg cacagaacat attgagcaag aatgcgcctg 206701 ccaaacggga gaatgcgact gaaaatccag cggcagttct ggaaaaggca tatagcaggc 206761 ttaagtcaca atcttcaact gggggaatca atcagttcaa ttattctaaa accagcgtgt 206821 cgggaaacag cgggacgttc agcaaagtgt atcaatcagc gaatgatcga acagtgacag 206881 acacagggga agaaacagtg attcaatccc aaaaccccta tgaatctgag agtgatatca 206941 gaatcaaaat actagatgaa aaatacagca ggatgaatgc gattaataaa acaaagtctg 207001 atccattagg ctatattaag gataagtacc aaaattcaaa gtctccttat ttcagaagtg 207061 atctgtcagc tgcagaaaga caggccgctt acgataatga aacagaatgg ttattcaaag 207121 ggaaggcgca aaactataac cttcaggatg ctgtgtttcg gaatgtcaca tttcatgggg 207181 aagtggaagc tgagaatgaa aaggtgtatc agcggggaca ggttaaccag cagctgcaag 207241 tactgttgaa tcgaaaccat attcatattc cagaggggac agagctgacg tttacaatca 207301 caccgattga ctatcaggtg cgggtaagcg ggacagacga tcaggatctg atcaagcaaa 207361 ttgagcaagt gctgcaatct ggagacaaca gcaaagaact atttttacac atcatgaaaa 207421 gtcaaagcag tgattcagca caattttccg aagaggccta taaaaagtat caggcagctc 207481 gtgagatgta tgaagttaca ggctaccatt tgaaggattt agaagtgatt gatgggcggt 207541 acgtcacgcc tgagggacgt gacttaatgg atgtatataa ggaagagctt gaaaaagatc 207601 cagtgcagaa acaaacggct tcttatgcta tatcttacta tcgttcagag ctcagtaaaa 207661 tcgcggaagc cgggtataat gccattccgg atttcatcct atcaattgat tacagcaatg 207721 gatctctgag agatgtggga caaagcaaga gctatgggac cggagatacc gggtggcttg 207781 aagcattaaa gcgtcaaacg ggtgtgaatt attaggtaag ctgttcatgt aggacagctt 207841 attttttatg agaatctaag gggtgaatta atcccaatat tcaaataatt ttattatttt 207901 tatataaaag attttaaaag aagtgaacga ttcaaaactc tgaacaaagg tgtttacctg 207961 aaaaaaacaa ttgtattttc cagagaaatt tattatgatg aaataagtaa tttaggagat 208021 tatataacaa ttttaagttt gaattttctg attgttatca ctgattcatg tgaaggcaag 208081 caggtctgct gttttctcat ttatgagtat tttgttagga ggaggaagag gagtggcaaa 208141 taaagaatta aagaggggcc tgggcgcgcg ccatattcag atgatcgcct tgggcggtac 208201 aatcggtgtt ggcttgttta tgggttctgc cagcacgatt tcatggactg gcccatctgt 208261 ccttctggct tatgcaatat gcggaatttt tatctttttt attatgcgtg cgatgggtga 208321 aatgctgtat gtcgagccga gcacaggttc ttttgcgacg ttcggccatc aatatattca 208381 tccgatggca ggttatataa cagcatggag caactggttc cagtggatta tcgtcggcat 208441 gtcagaaatt atcgctgtcg gttcttatac gaagtattgg ttcccggatt tgcctgcttg 208501 gatacctggt atcgtggcaa tggtgattct tggtgcggcg aatttaattt ctgttaagtc 208561 gtttggggaa tttgagtttt ggtttgcgat gattaaaatc gtgacgatta tcttgatgat 208621 tattgcggga atcggaatta ttttcttcgg ttttggcaat ggcggagatg cgatcggttt 208681 gtcgaacctg tggtctcacg ggggcttctt tgcaggaggt ttctcaggtt tcttctttgc 208741 actgtctctt gtcattgcag cctatcaagg agttgagctg atcgggatta cagcgggtga 208801 agcgaaggac ccgcaaaaca cgctaagaaa tgcgattcaa agtattatct ggcgtatttt 208861 gattttctac attggcgcta tttttgtgat cgtgacggtg tatccttggg atgagctcaa 208921 ctcactcgga agtccgtttg tgtctacgtt ctcgaaaatt ggaattacgg cagcggccgg 208981 cattattaac tttgtcgtga ttactgcggc aatgtccggc tgtaacagcg gtattttcag 209041 cgcgggccgc atgctgtata cactgggtgt caatggacaa gcaccgaaat tctttaagaa 209101 gatttcacgc aatggtgtgc cgctgtatgg cacaattgcg gtgctgatcg gtttggctgt 209161 cggcgttgta ctgaactata tcgcgccgcc gaagatcttt gtctatgtat acagcgcaag 209221 cgtgctccca gggatgattc cttggtttat cattttgatc agccatatcg gattcagaaa 209281 agcgaagggt gctgcattag ataaacatcc attcaaaatg ccgtttgctc cttttacaaa 209341 ctatttgacg attgctttct tgctgatggt tctggttggc atgtggttta acgatgatac 209401 tcgtatctcc ctgattgtag gcgtgatttt cttagcgctt gtggtcatta gttattatgt 209461 gtttgggatt ggcaaacgca cgcaggccaa tttgacaaaa agcgaacaag cagctgaata 209521 acgataaaaa agagacattc acggatgtct ctttttttat ttttcgcgta tggattttcc 209581 ctattttagc aagctatagg gtaaagatag cagaaggaaa ggtgttcata aaatggatgt 209641 tacactcggt tatttgcgcg aatcactttc gaatcatcta gaaaatgaag tctgccagcg 209701 tatttgcaag aagatgctgg cgaagcgtta tgcaaatgaa gaggaatttg taaaagactt 209761 agatgataat gaaatgtctt ttttgaacca tgtattagaa aaagaaatta agtatgccca 209821 gaatgaacag gatcaaaaac gggccaagga attaaacgag gtgtatgaat tactgctttg 209881 agaaaggcgg gtaagaaatg ggagcaattg aacgaagcgg atatacattt cagccggagt 209941 ttagcgttgt ccgtcaaaac ggagccatcc atgtgtacca tcaaggagaa tttgtggaag 210001 aaatcgaatt tgaatttaac ggggaatatc ccgatcatga tttgattgaa gagcttgtga 210061 atcattattg ttttgagcat gagatttaga gccctgccgt gcagggctct tttatttagg 210121 atgtaatcag gccatacttt ttcaggatat ccacggtgat gtttttggct tttgtgccgg 210181 aatcatcgac attggtgaca aagacataag agccatgctc tgttttgatg aatccgacaa 210241 accatcctaa tcccatatca gtcaggcggg ttccggtttt cccgtagagc gtgtaatgat 210301 cgccttcctc ttgaatcatc atgcgcttga cgattttcat caccggcttg tcaaatggaa 210361 gctcctcttt agccagtttc tccaaaaaag tttcttgttc cagcggagat attgtgagcg 210421 agctttgcag ccaaaactgg tcgattcccc cgctgatatc ctcgttgccg taagatagag 210481 tatgaagcca tgttttcatt ctttcctcgc cgatatctct cgctaatgcc tgataatacc 210541 agattgcgga ttcgcgcatg gccgagccaa gcgtatggtc gcggttccat gattcgaatt 210601 cacgcttgac cccgtcccat cgtttaacat cgtattcatc tcttacagct ttgacctgca 210661 aaccgattaa agcgttcacg actttaaagg tggattgcgg agtttgtctt tgatttgccc 210721 gttttctgtt atagacaaat gtctgatcct tttgtaaatc gtgaagaatg aaggttccat 210781 ccgtatcctt gaattcatca tcgacattca ttttgctgac attcaagtgt ttttcatgag 210841 cagatgatgc tgcgtggacg gagaagccgc cgatccctgc aatactcagc acaagcacaa 210901 catatatcca ttttttcatt ttgttctccc cttcgttttg attaactacc ttttctctct 210961 ttcgtttgtt cttcctttaa aaaataatca aaaagcgctt aaatttggtt ttgcaaacaa 211021 atactgttac tgggtttata gtcggaagat aacgtgaaaa tagagggtaa aaaggaaggc 211081 agggtaagcg gatgaatgag cagattccac atgacaaaag tctcgataac agtctgacac 211141 tgctgaagga agggtattta tttattaaaa acagaacaga gcgctacaat tcagatctgt 211201 ttcaggcccg tttgttggga aaaaacttta tttgcatgac tggcgctgag gcggcgaagg 211261 tgttttatga tacggatcga ttccagcggc agaacgcttt gcctaagcgg gtgcagaaat 211321 cgctgtttgg tgttaatgcg attcagggaa tggatggcag cgcgcatatc catcggaaga 211381 tgctttttct gtcattgatg acaccgccgc atcaaaaacg tttggctgag ttgatgacag 211441 aggagtggaa agcagcagtc acaagatggg agaaggcaga tgaggttgtg ttatttgaag 211501 aagcaaaaga aatcctgtgc cgggtagcgt gctattgggc aggtgttccg ttgaaggaaa 211561 cggaagtcaa agagagagcg gatgacttca ttgacatggt cgacgcgttc ggtgctgtgg 211621 gaccgcggca ttggaaagga agaagagcaa ggccgcgtgc ggaagagtgg attgaagtca 211681 tgattgaaga tgctcgtgcc ggcttgctga aaacgacttc cggaacagcg ctgcatgaaa 211741 tggcttttca cacacaagaa gatggaagcc agctggattc ccgcatggca gccattgagc 211801 tgattaatgt actgcggcct attgtcgcca tttcttactt tctggtgttt tcagctttgg 211861 cgcttcatga gcatccgaag tataaggaat ggctgcggtc tggaaacagc cgggaaagag 211921 aaatgtttgt gcaggaggtc cgcagatatt atccgttcgg cccgttttta ggggcgcttg 211981 tcaaaaaaga ttttgtatgg aataactgtg agtttaagaa gggcacatcg gtgctgcttg 212041 atttatatgg aacgaaccac gaccctcgtc tatgggatca tcccgatgaa ttccggccgg 212101 aacgatttgc ggagcgggaa gaaaatctgt ttgatatgat tcctcaaggc ggggggcacg 212161 ccgagaaagg ccaccgctgt ccaggggaag gcattacaat tgaagtcatg aaagcgagcc 212221 tggatttcct cgtccatcag attgaatacg atgttccgga acaatcactg cattacagtc 212281 tcgccagaat gccatcattg cctgaaagcg gcttcgtaat gagcggaatc agacgaaaaa 212341 gttaaattaa aaagctctct tcctttatcg aagagagctt tttgattact tctttttttc 212401 atcgtagtat tggacgggat acatggagcc ttctgatacc attttgttgt cctcgatatc 212461 ttgcgggtcc gggtggccgg ctttatcaac tgggaacgtt tccatgtctg gctgttttgt 212521 tattttcatc ttcatgctgt gaatgaattc tcttgccttt tggcgatttg acgggtcttt 212581 taatagataa gaagtgatgc cgacagttga aacagcgaga cctgaaagta acagcttttg 212641 tttcatggtg atactccttt ctattttaag aatagtgttt cctgtatcat tcccgttttg 212701 gaaattgcta aacctgttgt gtttttatca ttggaattaa cagtaaattc catttaagaa 212761 gaaactagtg acttcattcc tgtattggaa ggtaatatac attgacttat tatagatttc 212821 agtcaaaatt cgataaatat tgacaaagta aagtaatcag aataataata taattagcaa 212881 gagaatgtca tcatacatga aaggtgttta cgatatgaat caattgcatc gaagaatggg 212941 aacgttttcc ctcatgatgg tcgggctcgg gtcgatgatc ggttcaggct ggctgttcgg 213001 ggcttggcgt gcggctcaaa tagcaggacc agctgctatt atttcatggg ttattggaat 213061 ggtcgtcatt ttatttattg ctctttctta tagtgaacta ggttctatgt tccctgaagc 213121 ggggggaatg gtcaaataca cgcaatattc acacggttcg tttatcggtt ttattgcggg 213181 ctgggccaac tggattgcga ttgtgtccgt cattccggtt gaagcggtgg cctccgttca 213241 atatatgagt tcttggcctt gggaatgggc gaaatggaca agcggtttgg tgaagaatgg 213301 aacgctgact ggggaaggac tagcgtttgc ctctgtattg cttctcattt attttctgct 213361 gaactactgg acagtcaatc tattttcgaa agcgaattca ttaattacga tttttaaaat 213421 tattattccg ggtcttacga ttggagcttt gctgtttgtc ggattccacg gagaaaactt 213481 tactggcggt caaagcattg cgccgaatgg ctgggcaagt gtgctgacgg cggttgccac 213541 ttccggtatc gtttttgcgt ttaatggttt ccaaagcccg attaatatgg cgggtgaagc 213601 aaaaaatccg gggaaatcaa tcccgattgc ggttgttggc tctctttttg ttgcgacagt 213661 gatttatgtc ctgctgcaga tcgccttcat tggagctgtg aatccttctg atattgctca 213721 cggctggagc catctgaatt ttaattctcc ttttgctgat ctggcgattg cgctgaatat 213781 taactggctt gttattgtgt tatatgcaga tgcatttgta tcaccgtctg gaacggggat 213841 tacgtatacg gcgacaacgt cccgaatgat ttacggaatg gaaaaaaaca aatacatgcc 213901 gagtatattc gggaagcttc atccgattta cggcgttccg cgacaagcaa tgttctttaa 213961 cttgattgtt tcgttcatct ttttgttcct gttcagagga tggggcgtat tagcggaaat 214021 tatttctgtt gctacgttaa tttcttatat caccggcccg atcacagtga tgacattgag 214081 acggacgggg aaagacctgt acaggcctct tcgtttaaaa ggcttaaatg tgattgctcc 214141 gcttggattt atctttgcgt cactggtgct gtattgggcg cgctggccgt taacaggaca 214201 ggttctgttt attatcctga tcggtcttcc gatttatttc tattatcagg cgaaggcgaa 214261 atggaaaggg tttggccgga actttaaagc cggcgtctgg atggtgtttt atctgctggc 214321 catgatggtt atttcttatt tgggcagtga taaattcggc ggcctgaatg tcattcatta 214381 tggctgggat atggttctga ttgcgatggt atcccttgta ttctatgtgt gggcgctgaa 214441 gagcggctac cagacagaat acttaaagga tgcgaaagag ataaattctc agctgcttaa 214501 tggacagtca gaagctgctg ccggaaaaga ataaaatata gaagaaaacc ttgcgatagt 214561 tgtcgcaagg ttttttgctt ttaataaccc ttttttactt tgtggaaaag atcaggatag 214621 ttggtgaaca ctcctgttac gccccaatca agcaggcgat gcatatcagc ttcattattg 214681 actgtgtaag gatgaagcag gaggccgtgg ctgcggatca tacggacgtt ttcttgattt 214741 aaagctttat aatccgggcc cgcaccgaca gcgtatgttt tgatttcttc cagggcagca 214801 tctgtcattg acgccatttg tttggcttcc agcaattgaa cggtcggcag gtttggctgt 214861 aattgatgga cttttaccag gctttctttg ctgaacgatt gaatgatcac ctggcctggc 214921 ttagaatgct ttcccagtaa tttatgtttc tgcaaagaag cgatcagttt ttcttccata 214981 cctgggtagg tgtcaggcga ttttgtttca atgtagtagt tcgcgtgctt tccgaaacgg 215041 tctaatacct cttctaatgt aggaacttta aggccgacgt actgcggctt tgctttttcc 215101 ggataggctt cattaaacca agaaccggcg tcaagcttct taatgtctgc gagcgtatgg 215161 tctttcaccc aacccattcc gtttgtggtg cggtccagtt tttcgtcatg catgacaatc 215221 aattttccgt cttttgtcat ttgcagatcc aattcaataa aatcagcttt cattttctga 215281 gcggtttcgt aagacagaat cgtgtgctca ggcacatatc cagaagcccc tctgtgcgcg 215341 acggtcagga tacggtcagg tgacagcagg tttccttttg acgctgccga cactggcgtt 215401 accataaatg agagtaagcc cagcgacaga acaaacaagg ccagtattct attttttctc 215461 atgatttctc ctccttatag ataagcacta cctgtctttc ataataaaaa acggatgtaa 215521 acggcgtgtt ggaaaactat taatctttta tgtgtctttc ttaaacatgc tctgcccgtt 215581 ttcctgtatt ccacgtcaaa gccaagaaga cgatggcaag aatgcaggat gagatcagca 215641 tgataaagcc gccgttccag ttaaaacggt ccacgacaaa gcccataatg gcgtttgcga 215701 aggcggatcc gccgatgtat ccgaaaaatc cggtcaaacc ggctgcagtt ccggctgctt 215761 ttttcggtgc taggtcaatt gcttgaaggc cgatcagcat aacaggtccg tagattaaga 215821 agccaatgct gatcagggcg atattgtcca cgagcggatt gccggccgga ttcagccagt 215881 acaccaatac ggcaatgaaa acacccgcca taaacaaaac gcctgccggt gcccggcggc 215941 ttttgaagaa tcggtcactg atccagccgc acaagatcgt tcccggtatg cctgcgtatt 216001 cgtaaagaaa atacgaccag cgtgagtctt caggagaaaa gcctttggct tctgttaagt 216061 aagtaggcgc ccagtcaacc acgccgtatc gcacgaaata aacaaataca ttggcaaaag 216121 cgatgtacca aagaaatttg ttgttcagca catattgaaa aagaatttct tttgttgtta 216181 attctttttc ctgattttta aaagcgtgtt ttggatagtc attccgatac tcttcaattg 216241 gcgggagtcc gcaggattga ggcgtatcac gaaccaataa aacaattaaa aatgaaatga 216301 taatggcgat gatggcaggg aagaaaaaca cgcttttcca agtgacgaac atcgcgatcc 216361 caagagtgac aagcggagca agaataccgc cgcctatgtt atgggcgaca ttccagatcg 216421 acatttttgt gccgcgttca cttatggaga accaatgggc catcgtcctg ccgcatggcg 216481 gccagcccat tccttgaaac catccgttga taaacataaa aataaacatg atggtgacgc 216541 tcgaagtcac ccaaggcatt gaaacgaata gaatattaac gattgctgat aaaaataggc 216601 ctgtcgccag aaaatatctc ggattacagc ggtcagacac cattcccatg atgaatttgc 216661 tgaagccgta cgcaatggac acagcggcca gcaccaaacc cagttctgtt ttcgaaaatc 216721 cctgttcctg cagataagga atggcaaagg caaagttttt ccgcagcagg tagtagcctg 216781 cgtagccaat gaaaatacca atgaatactt gcagtctgag ccgtttgtat gccgcatcca 216841 tctttgaatc atccagtctc tcaatatgag gagccggttt aaatatatta agcattaata 216901 attatccccc tttgctgttt gtgctggatg tgtggcgtgc ctcctttccc gaaaaacaaa 216961 aagagccaga aaacacccct tgtcaaaagg ggttggattc ctggctctcc tcatctccat 217021 ccaagctatt aacttatcat gatagcgctt tcttaaatta tcatagtccg gagcgaatgt 217081 aaacgggtaa ttttcaaatt gggccttagg gaagtgaata ttatcctttt actaaatgca 217141 attatatttt tttactagta acataaaaat ctggagggag gctgtttaaa gatggatgaa 217201 ttagatatcg cattctttat tttaccgtta ggaattatgc tgctatcgat tgtcgggacc 217261 tgtatttgta aaaacccgta tctgatgcca atgcttagtt tggtgatttc tcttgtgctc 217321 acctttacca tttttaatca atcatttttg ggatgggctg ttgtctatag cttggtttct 217381 ctggctttat cctatatcac attgattgtg gtaaggaaaa ggaaggaatc aggaaattaa 217441 aaagacctca ctttctaaca tatcgttgac taaagcaact atatgtgatt ataattgctt 217501 tagtcaacga tattagaaag tgggaattga tttgaaaaca agagaatcat ctgtcgggtt 217561 aaaattcaga aagttcaatc gattttatac aaacgtcctt ggtttcctta atgagcacat 217621 ttacgacagc ccgttttcct taacagaaac acggatttta tttgagattt ataatacgcc 217681 taattgtacg gcaaaagctc ttcaggataa gctggggctt gaccggggat atgtcagcag 217741 gattgtgaag cagtttgaaa aagaagattt gatttataaa cagaggagca aagatgacgc 217801 ccgccaccat tacatttttg tcacagaaac aggaaaaacg atttataaaa agctggagga 217861 gaaagccaac gaacaagtag aactgatgct gaaggtaatc aaccaaaagg agcagcacaa 217921 gcttgccgag gcgatggcag agattgaagc gatcctttca cagtcgcttt ctgccagagc 217981 atcagagata tcgattagag attattttct ttcggaggat cttcaactcc ttattgagaa 218041 acaaagacaa ttttacgcgg aggctcacgg ttgggatgac acgtttttag cttatcttca 218101 ggagacattt gacgctgaca tcgaaaaaat atggattgcg gaaagcggcg ggaaatttgc 218161 cggctctgtc gggttggtca agcacgatga aaagacagtc cagctcagat ggtttctggt 218221 tgatgcggat tttcggggca gggggcttgg cacgcaattg ctggagcatc tggttgcata 218281 ctgccaagac atgaagtttg accgcatttt cctttggacg gtgagcacga tggctgaggc 218341 tcgtccgctc tataaaaaat ttggattcag gataagtgaa gtaaaacaag aagcgccatt 218401 atggggacag cagctgacag aagaacggtg ggatttggag ctgtcatgaa aagactgcat 218461 tatgcgtgga tcatcgtctc cgtcaccttt ttgatcttat tggcggttca gggggtgcgg 218521 ctgtcgtttg gtgcgtttgt ggagccgtgg gaacggcagt tttcaatcga tagaagcacc 218581 atctcgctga tttcgacggt gagttttatt gtttatggca tatcacagcc tgtgatcggt 218641 cggcttgtgg acaaatgggg tgcccgggct gttttggcat ggagtgcgtt actgacagga 218701 gtcagcattt tcttaacata ccttgtgact tcgccttggc agctgttttt gctttacggg 218761 ctgggtgtct cgcttggagt gggcggagca tcgaatgtgg cggcaagtgt attggtcgtc 218821 aattggttca gcaaaaagcg gggactagcc tttgggatca tggaagcagg ctttggcgcg 218881 gggcaaatgc ttctcgttcc cggctcactc atgttgatcc attggtttag ctggaagctg 218941 acggttgtgg tgttgggact gctgttaatc gtgattgtct ttccggctgc gctgctgatg 219001 ctgcggaaca atccttcaga aaagaataca gagccgatag gcggactggc tgcatcagaa 219061 aaagaaacag cacccaaaac aacagctctt tcagtggccg ggatgtttcg tatgaggcaa 219121 ttctggttct tgatttttcc gtttttgatc tgtggattta cgaccgtggg gctgatggat 219181 acccatttga ttccgttttc tcatgatcat ggcttttcaa cgacagtcac gagtgctgct 219241 gtcagtctgc tagcaggctt taatattgct gggatcttgc tgtccggaat tgtagcggac 219301 cggtggagca gccggaaaat cctgtgcatt ttatatgcgg tgcgggcgct gtcgatcgtg 219361 attcttattt acagccacga gccctacttg cttttagcct ttgcgattct gtttggatta 219421 gtggactttg caacggtagc accgactcaa atgctcgcca cccagtactt tcaaaactac 219481 tcgatcggcc tcatgattgg ctggctgtca ctcgcccatc agatcggatc ggcactaggt 219541 gcgtatgtgc ccggcgtcat ctacacggta acgggtgagt atacactggc tttttatttg 219601 tcgattggaa tgctcgtgct tgcgagcgta atgaatgtga tgctgaggga gccagctgcg 219661 gttacgcgtg acagtgcggc tgtggtagac aagtgatgag gacaaaggga aagcatctct 219721 gatttcgaga ttattcagag atgctttttt tgtatttttg ttctaatacg aagtcgatca 219781 taccgactat gcgggcgttt tcggattttt gtttgaagcg ttcagaaatt tgaacttttc 219841 ttgaaaatgg ggaaacaata aaaacccaaa aaaggccgat caaggcaaaa aacatttgta 219901 cagctaattc tattaattca ttaaaacgag tgctgaaaaa atagaagtat aacgttatta 219961 atgtcacagt acatacgatt ttggcaagtg tgtttgaatg taagcaatgg ttcactaaag 220021 aataccttta attgattcag catgattgaa tcatatttgt ttaggaaaat aagaagttct 220081 ttatcatctt ttttatgttc taaaataaag ttgctgtttc tgtttcttta tatgtatggt 220141 ggtctacatt caatatatac atctcttaaa gtataaaaat tgagtatttc ttagtaagga 220201 tgaaacaaaa ttacatgatt tttttgttat atctttcagt tagaataaaa tctataactc 220261 ctctcattcg caaatattcg gctctctgtg caaagtgcag aacagtatgt aattgtcctt 220321 ttctagatat atttaaaagc tttatcaaat caataaggat tttcaagaaa ataattaata 220381 atagaaagat aaaaatgtgt ggtatgtcaa tgtaattgat ttgtcctgaa aataaagaag 220441 ttgcatagac aacaataata cttccgcaaa acatcaaact catataatgt ggaagggaaa 220501 atggacgagt tgaaaaatat gcttttaatt ggcttagcat agcattatct cttgtatcta 220561 agtagcccaa aagctcttta tcatttttac taattgtaag aacatgattc aatacagcac 220621 taaaattcat tgaatcttca ttatcagagg cagtatgttt attagcctgt atgttttgtt 220681 gatccatttt atatttttta taaagtattg tattaattaa cttgtttttc tcatagaatt 220741 cagatcgttg attaagggat gcttttcctt tgtttttatt tccttttttt atgattttag 220801 tataagtcat aaaaatacaa atgactgtaa aaatagaaaa cactgcaggt gaaatatctg 220861 aaagaatagt attggtgaag acttcttttg cttggatgaa aaggaaagaa gctaaagtca 220921 tagatataaa catgcataaa actgctactt tcacaagaaa ctgaagcgga agagaaggtt 220981 ccgaataata gtgcttcaac tggttgagtg tcagagaatc ttggcgaaaa agataatcta 221041 ttatctcctg ctgattttgc atctgattga tatcatgagc gatgtttttt gttttttcaa 221101 aaactatttg atcatttttc atttttgata aacctccaaa agacgataga taaactaaaa 221161 aaactgcatg agcatatttt aacttatgtt catgcagttt tgtattaaag ttagctagta 221221 taataagcaa aaatggccag taacatagca gataatgcgg tagcgacttt gactccttta 221281 ttgttcgtta aatcactgcc catattccca attagtaaaa gtgcagcaac acctacaaca 221341 gggaataaat attgatcata agacggccaa tctaacgcta attcactctc gggagacgta 221401 actggtactc ccttgtacgt ctttatttta aacgtaatcg tagtcgttag tccagttgtg 221461 acattgtcac cgactggaat atcaggtgta tagattttaa tttgaatgtt taaagattca 221521 gctgttggat ttacataaac ctccaaataa ccgttgcgta ctgataagct cagactattt 221581 aaaaggtttt gataagagtc gatttgtgac gcagtgagag acgtttgagt gtcgcccaat 221641 aaacccgtga tataggcacc tggtttacca tttgtaatgg taattgtgtt tggtgaacct 221701 tcacttggta tggttgccag aagtgaagtt gatagaataa tatccaactc aggtgatgtg 221761 aaaatggttt ctgtcgtatc aaattcaaac atcgcgtttg ccagacttgt tagattttct 221821 aaagctggaa tggtagataa aatgtctgtc agtgtacgca gtcttgcatc atataccgga 221881 tcagacggcg gatttacatt gcttgcacct gagtctcttc ctgaataccc gtctttatca 221941 atcccgatgc ttccagagcc gcttccgatg gttccttcat aaaattgatc aaaggcccag 222001 ttgtttggca tcggatagcc gagattgccg ctaaatcctg ttgacatatt tgccacaaaa 222061 ctatactttg tcagtcctgc ttcagatgta cggatacaaa tgtttcttgg tccgtaaacc 222121 cctatttcat acttaggtgc ggttgaaaat gtctgcattt ttgtaaatgc tgacttaatc 222181 tcttggaaat aaggaatgat tttatcggtc acttcataat cgtatgcatc aaaatcgaca 222241 gcgaaataaa tggtcgtgcc tgacggaaaa cctaatcttc tagcagcaga agcggcacta 222301 tatgcatctc ttgtgccttg gtctttgaca aaataagaag attcatagcc gccgtcttga 222361 taaattggga aaaccttcaa tccggcatca agaataactg caagctcttt agatgtcagg 222421 gctttagatg tgaggccgct gcttgtccgc acatttccgg tcaaatatct gccaaccgtt 222481 ttataaccgt tattccgcag tgtttgagct ttttctgcgg ttataattgt agcagtgtca 222541 caagcagaag cggtgcgagt tgtgtctcct gagcttgata ataaagcttt aatggttggc 222601 atatctgcat aacctgtttg cggcaggcac atgaactctt gaaatgcttt aacagctgaa 222661 acaacaccca caccatattt gccgtcaaac tcaccaggat cgaacgattt tccgttacaa 222721 tagagggcgt actgaacaat taagacaaat cctgttcttg aatcgccggg agttaaagta 222781 gggcacaaac ttgtggtgcc gtttccgaaa aatccattgg caacacttgt gctcatgcct 222841 tcttcttttt gcagggcata aataagagct ttatttgtat cgcggccata cagtccgtca 222901 caaggcatta acccgatata gtcattgtag tctcgattta agttttgttg aatctggcga 222961 attcttgaat cacccccaga caccagctta aaagcgctca tgtctaataa ggctttcata 223021 attaacgtgg tgacaatccc atcctgtgtt gtcagtccgg cagctttttg aaattctttt 223081 accgcatttt ctgttttttc gtaaaagacg cctgtaaaac cgccgggatt aaagccttta 223141 caccataaag ccccttgtaa aataaaattc atgttgcttg gttttgaatc tggagcttgg 223201 cgtttaagag gcttaaataa gcgctgtgtt gtcggcccga agttatcggc tggctctgag 223261 atacccaatt caatttgaag cgcccgagtc agaccgtaga tcgtatccca cccagttttc 223321 ccgctttctt caactgggtt atacccatgt ttgccgctgt acgtatcgtt cagccattgc 223381 tgtgtgatta agaccatttc atcaaccatt tcgattcctc ctttgttaga ttgcgttcat 223441 ttataggtgg caaacgtagg acaaaataaa aaaatggatg ccgttaagca tccattttac 223501 atccgttctc caacagcttc gctttcggtt tcagctctga aatgtagagg cctaaaagtg 223561 taagcgcgcc tcctagaaga gcgatccatg tcatgttttc gtgcagaatc aggacagaag 223621 cggcgatcgt gataaccggg accatgtaaa tatacgcact ggatttgacg gctccgagca 223681 ctccaactga ataattccaa gtggcgaagc acagggcaga agcgccaatc cctaagaaaa 223741 gcatgttgag tatatttgaa gcagatgaaa atcggcttag gtcaaaatgg aagtcgaaca 223801 aaaataaagc gggaaccata aacaataaac catacaaaaa tactctctgt gtcagctcga 223861 tgatgtggta ttcgtaggcg cttaattttt tcatgaatat cgagtatccg ccaaacacga 223921 gagcagcccc ggctgccatg atgtctccga gcggatttag acgcagtacc acattgccgt 223981 taaacgtaat caataaaagc ccgatcagtg ccgagataaa tccaatcaaa aaagtcagac 224041 gcaatttttc gccttcgagc agaaaatggg ccaaaaccgc agtgatcatc ggtataatgg 224101 acacgatcat gccgacattg gaggcgtatg tataggtgag agctatattt tctaatagaa 224161 agtataaggt tacgccaaat aaaccagctc cggcaaacaa cagctcctgc cgccaatttc 224221 tgaacggaat catgttggga cggacgagga taagagcgat aaagcccatc aaaaaccgat 224281 aaaataatat ttccattgga gagaagtcag ccagcagaac ttttgtcgaa ataaaggtcg 224341 tcccccaaat cagaatggtc acaatggctg cgatatgccc cgaagtttct ctttgtatgt 224401 tcatctgtga agctcctttt caaaaatctt catgtattgc ttcggcgtca gccccacctg 224461 ccgtttaaaa aacttcgtca tatgactctg atcgctgaat cctgtctgaa atgccgcatc 224521 aatcggcctt accccttgtt caaggagttt tttggcttga ttaatccgga ttgtttccat 224581 gtagctatta ggggtaatgc ctttttgttt tgtaaatgaa cgcaataaat gatacttgct 224641 ccagcctgtt aattcactca aatcattgag tgtaacattt tcggcataat gctcttctaa 224701 aaattcacaa accattttga cttcgtctga tggttctgga acgctgctaa ggaacgtgac 224761 atctgaataa tggcggatca gctcctctaa tagatgaaga aacagctcct ccttacgcaa 224821 agcttgtttt tcctcggata tcaaaatatg caattcctgc aggctggctg tcagctcatg 224881 gcggaataac acatgctggg agaaataagg gagatgcccg gagccagtaa tctctttcac 224941 cgccttctcc atgatatccg gcatgacatt gatacaccga taatcaagcg tccggccgtc 225001 aatctgttca cagctatgcg tgtcacgggg gttaaagagg agaagatcac ctggattgat 225061 gatatattct tgatcctgac aggccagata ccgttgccct ttttcaataa atccaatcac 225121 ataataatcg tgaaagtggt tcgggaactt ctgcataatt cccttgaagc ggtaggcttc 225181 tatatgaagg tgtgggtcaa gctgcagtgt gcgggtttcg ttttgcatgg gatgcctcct 225241 gtcggtgtgg tggtcttgga ttaagtgtag catgattttg ggggatttct tgtatgatgt 225301 tgctgtttag gaatagagaa agcagaccgt tatttgtctg ctttcgttta agaatttaaa 225361 agattttaac cctcaataat aattttatct tttttaataa aaatttattt ttcaaatatt 225421 tcagttataa tggtttggaa cagataggag gggcaaagat gtatcaatca aagaaggttt 225481 tattgttagg ttcaggtgaa ttaggtaaag aggtagtgat tgaagcccag cgtcttgggg 225541 tacagacggt ggcagttgac agttacgagc atgctccggc gatgcaggtc gcgcataaca 225601 gttatgtcgt tgatatgctg gacccagagc agatcagaac catcattgag aaagaaaatc 225661 cggatttgat tgtgcctgag gttgaggcga ttgcgacgga tgaattgctg aagcttgaag 225721 aggaaggatt tcacgttatc ccgaatgccc gtgcggccaa gctgacgatg gatcgggaag 225781 gcatcagacg acttgcggcg gaaacgcttg gacttgcgac agctggctat gaatttgcga 225841 atacatatga tgaatttata caagcggcag ctcagatcgg ttttccttgt gtcgttaaac 225901 cattgatgag ttcttctgga aaaggccaaa gtgtgtgccg ctctgaagcg gatttagaga 225961 gctgctggga gacggcgatg gaaggcggac gggtgaaaaa cggccgcgtg atcgttgagg 226021 agtttatccc tttcgaatca gaaatcacac tcttaaccgt acgtgcggtt aacggtacgg 226081 cattttgtga gccgatcggt catgtgcaaa aggacgggga ttatatcgaa tcgtggcagc 226141 cgcatgatat gacagagcag caaatagaag aagcgaagca tattgcgaaa acgatcacgg 226201 atgagcttgg cggatacggc ctgtttggtg ttgagctgtt ccttgcgaaa gatagggtat 226261 atttcagtga ggtatctcct cgtccgcatg atacgggtct tgtcacgctg gtgacgcaaa 226321 atttgtcaga atttgcgctg catgtccggg cgattctcgg ctttccgatt acagaaatca 226381 cacagctttc tcctggcgcc agcaggcccc tcaaagcgcc ggaagaatta gcggattaca 226441 ctgttgaagg attggaaaac gcactggcag tcccaaagac tcaagtgcgc gtctttggaa 226501 agccgataac aaaagccgga cgtcgtatgg cagttgcgct ttctgctgct gattcagttg 226561 aaacggcaag agagaatgca aagaaagcgt tggaccagct aattttaaaa tagagtttga 226621 acaggtcttg tcatgggaca aggcctgttt ttttctttct ccgtaaaagt tttatcataa 226681 gaatcagaaa cctgattata atgtaaaagt cttccatcga tacgggtggt tgacactaaa 226741 ggagggagat gacaaaatga aattagttcc aagattcaga aaacaatggt tcgcttactt 226801 aacggttttg tgtttggctt tggcagcagc ggtttctttt ggcgtaccgg caaaagcggc 226861 agagaacccg caaacttctg tatcgaatac cggtaaagaa gctgatgcta cgaaaaacca 226921 aacgtcaaaa gcagatcagg tttccgcccc ttatgaggga accggaaaaa caagtaaatc 226981 gttatacggc ggccaaacgg aactggaaaa aaacattcaa accttacagc cttcgagcat 227041 tatcggaact gatgaacgca ccagaatctc cagcacgaca tcttttccat atagagcaac 227101 cgttcaactg tcaatcaagt atcccaacac ttcaagcact tatggatgta ccggattttt 227161 agtcaatcca aatacagtcg tcacggctgg acattgtgtg tacagccagg atcatggatg 227221 ggcttcgacg ataaccgccg cgccgggccg caatggttcg tcatatccgt acggtactta 227281 ttcaggcacg atgttttact ccgtcaaagg atggacggaa agcaaagaca ccaactatga 227341 ttacggagct attaaattaa acggttctcc tggaaacacg gttggctggt acggctaccg 227401 gactacaaac agcagcagtc ccgtgggcct ttcctcgtca gtgacaggat tcccatgtga 227461 caaaaccttt ggcacgatgt ggtctgatac aaagccgatt cgctccgctg aaacgtataa 227521 gctgacctat acaaccgata cgtacggctg ccaaagcggc tcgcctgttt atcgaaacta 227581 cagtgataca gggcagacag ctattgccat tcacacgaac ggaggatcgt catataactt 227641 gggaacaagg gtgacgaacg atgtattcaa caatattcaa tattgggcaa atcaataaat 227701 acagcaaact agccatattc atgtctattt tgtttttatg cgggtgcagt tcgcagacgc 227761 attcttctca aaaagaaacg actattcctg tcactcttca tgtggaggat gctaaggggc 227821 tgccggtcga aggggttcaa gtgacgattg tcaaagcgcc ctcttcagat gaggagccga 227881 gtacagagat tggcgagata ctcggtaaaa cagacaaaaa cggagatatc aaatgggata 227941 ccggcagaaa aggcgattac tcagtcgcgt tgacgaaggg tgaaacatca gtaacccatc 228001 acatctcgtt aacagaggat aaaaaagatc atgccattcc attagtcttc aaagaatagc 228061 agtttccttg attttaaggg aactgccttt tttatttatt gcaggaaacc aaactatata 228121 ctggaaattt attatgtgag ataataagaa ataggtattt tttcttacga gacaaaaggg 228181 gcgttatcct ttatatcaat caaacccgga ggaaaaagaa gaagatgata caagattcaa 228241 tgcagtttgc cgcggttgaa agtggtctgc gcttttacca ggcatatgat caaagccttt 228301 ctttgtggcc gattgagtcg gaagcattct atgtttctac tcgttttgga aaaacacata 228361 tcattgcaag tgggccaaag gacgcacctt cgctcatttt gcttcacgga ggccttttca 228421 gctctgcgat gtggtatccg aatatcgcag cgtggagcag tcaatttcgt acatatgcgg 228481 tcgatataat aggagacaaa aataaaagta taccatcagc agccatggaa acgagagctg 228541 attttgcaga atggatgaaa gatgtctttg attctcttgg acttgagacg gcacatctgg 228601 ccggcctttc gcttggcggg tcccatatcg tgaatttctt actccgcgcg cctgaaagag 228661 tagagcgggc ggttgttatc agtcccgctg aagcgtttat ttcatttcat ccggatgtct 228721 ataaatacgc tgcagagctt acaggggcaa gaggagctga atcatatatc aagtggatca 228781 caggcgacag ttatgatctg catcctttac tgcaaagaca aattgtggcg ggcgtggaat 228841 ggcaggatga gcaaaggagc ctgaagccga cagaaaacgg ctttccgtac gtgttcacag 228901 accaggaatt gaaatcaata caagtcccgg tacttctgat gttcggtgag cacgaggcta 228961 tgtaccatca gcaaatggcc tttgagcggg cttcggtatt ggtgccggga attcaggctg 229021 aaatcgtaaa gaacgccgga catctgttat ctctggagca gccagagtac gtcaatcaac 229081 gcgtcttgtc ctttttatgc ggggggataa aatagtaagg aacatgaaaa gattggcatt 229141 catttttcaa aaggtaacaa atgttgtata ataatagaat ttgaatgctg ctttttttgg 229201 gagcattcta tgttatcatg cttattggag aaaaattttt cctgtaacgc tattcgatca 229261 ctatcgtcaa ataatataga tggttttaca attggaggtt tggttacact gtgaattaca 229321 tcccctgtat gattacgata ggaaacttca tttgcggatt gctggcgatt cattccttgc 229381 tatatcacaa cattcattca gcagtgcttt ttatttttac aggcatgttc cttgatttct 229441 ttgacgggat ggctgctcgt aagctgaatg ccgtttctga tatggggaga gaactggatt 229501 cgtttgccga tctggttacg tttggggtgg ctccttctat gcttgcttac agtgtcgcgt 229561 tgtataccct gccatttatc gggatcttat gcgcattgac gtacagcatt tgcggaatgc 229621 ttcgcctctc taaatttaac attgaacaaa gcaagctccc gacgtttatc ggtatgccga 229681 ttccgtttgc gggcatgtgt ctcgttattc taagcttcac ctataacccg atccttctgg 229741 caatcggcac ttgcggactc tcatatttga tggtgagtaa aataaaattc cctcatttta 229801 aaaaacatgc ggcagaaaac ctggagtctg ggagatggaa ttagttcagc agctcatagc 229861 ggattacggt tatctcgcta tttttttgat gctggtatta ggaattgtag gattgccgat 229921 tccagatgaa gtgatgatga ccgttgttgg ctatttcacg cataccgatg tattgaatta 229981 tgagctttcg atattgatta gttttgtcgg ggctttgtta ggtatgctga tcagctacat 230041 gattggcaga aaagccggac gcccgtttat cgacaagtac ggcaagtggg tcggcttaaa 230101 agaaaaaaga atgatgaaag tggaaaaatg gatgaagaaa tacggtccat attctcttat 230161 tttaggttat tttattcccg gcgtcagaca tgtgacgtgc tacttttcgg ggatcggcaa 230221 aatggatctg aaaacgtatg ttgcgtttgc tgcaatcggc gcctttttat ggtgctttgt 230281 ttttattaca atcggaaggg ttatagggat tattcatgtt taatacggct gtaaagattc 230341 tgtatcgatc attgatagag ctgacgaatc atcgtctgtc atcctatctg attaaaggat 230401 tttgcgagtc gaaaatcagc aaaccggtca ttccgctttt ctcaaaacat tttcggctga 230461 attgggatga tgtggacggt acggctgctg attacggatc gctgtccgaa ttgttcattc 230521 gacaaataaa tctggagcgg cgccctgtgt caaaagaggc gcatgcggtg gtcagccctg 230581 ttgacggtgt ggttcagacg gtaggaatca tcaacccgaa tcaaaccttt acggtgaagg 230641 gaaaagatta ctcattcgct gagctgaccg gctgtaaaag cgcagaccat caatacaacg 230701 gcggatattt cgtcgtgctg tatttaagcc cgaggcatta tcaccgtttc cattctccga 230761 tcagctgcag gtatcaaaag ctggccgagc tcggaaatcg ctcatacccg gtaaatcaac 230821 taggcttaaa atacgggaaa gatgtgctgt cgaaaaatta tcggtttgtg tacgagctga 230881 atagcggcag ccgaaatgtc ctgatgattc ctgtcggcgc gatgaatatt aattctatcg 230941 tgcagacgaa tacccgtact gaattggaga tcggcgagga gctgggatac ttttcatttg 231001 gctcaaccgt cattttggtt tttgaaaaag acgcgttcca gccgtccgcc catttagcag 231061 aaggccaaga agtccaagtc ggagaactga taggttacga agaataaaaa gaggagcttg 231121 cataaacgca gcgcctcttt ttttgaagaa aggtgagatt catggagaaa caaatcatca 231181 gctggattac agattatcag aacaccggag atgaagccgt cctgcggcaa gtgcgagaag 231241 tgtgctggcc gatcgttgaa gcggttttgc aagagaaagt aatggatgat gaacaagcga 231301 acaatttgcg cgaaaaagga atcgagcggt ttccattcat catcagcaaa taccaagcgg 231361 atgtgcagct tccggttgag acatttttac aaaatacgta tcggttttac tttcatcagg 231421 tgatgagaga atccagctaa agcttctttc aacagagaag cttttttttg ttggcaggaa 231481 aaggaaactt tttctatatc tatctcgtaa tgactagaga acctagcaga aaaggagaga 231541 tagaattgaa acgaatgata gtgagaatga ccctgccgct gctgatcgtt tgtctggcgt 231601 tttcttcttt ttcagcctca gcccgtgctg cttctgaaga aaaatattgg gatcactgga 231661 ttgaacgaca tgcacagcct ctggatgctt ccaatgcttc aaacaaagac cttcgatttc 231721 taaaaaaggt gctgaaggga aaacgaatcg ttcagttagg agaaaccaca cacggtgctg 231781 gcgaaatcaa tgccacaaag gtcagaatga tcaaatacct ccacgaagag ctgggatacg 231841 atgtattggc ctttgaatcc ggctttcctg atacaaatgc atcctacctt aatatggacc 231901 aattaacccc taaaagcacg atgaaaaact ccatttacgc tgtatggcac acagaagatg 231961 tcgtcgaatt gtttgattac atgaaagagc aaaaagagaa aggcgatccg ctgatcctta 232021 ccggttttga tattcaaagc atgaagaatt cattcaatgt agctgcgact caatgggtaa 232081 aagcggtgga ccctgagaaa gcagagttgc tctcccaatc agaaaatgat ttttcaacat 232141 tagtgacaga cagcaatacg tttgatgaat tttcgcaaaa gaaggaaaag cttgtgaaaa 232201 actatcagaa gctgatcaag ttcactaaaa cacatgcttc agagctaaaa gaaaaccttc 232261 caaaagagcc gaaagcttat gagatgttta tgcattctct tcagctgaga attgacgtaa 232321 tggaaacata tatgctggaa gaaatgaaag aaaaactaga ggagtatccg gagaatattg 232381 aggatttttc attctttatg agagaccgca tgatggctga acaatttcag tgggtagccg 232441 acacccttta tccgaaaaag aaaatcattg tctggggcca caattaccat ctacgcaaac 232501 agaatacgaa gatgataaag gactgggtac agctaaacgg ccctaacatg ggtgattatt 232561 tgccggagcg gctgaaaaaa caaacatata cgattggcat ttatgcttac tcaggtgcga 232621 gtcttgatag ctccgataat aagactgtta agccggttac aagcccgccg ccgtctggga 232681 gccttgaagc tttgctgaaa gcggcggacc gaccggctgt ttttgttgat tttctccata 232741 caaaaaacaa gaaaggcact tcgtggatgt ataccccgcg gactgcgctc tattgggggt 232801 acatggaaga gcagatgatc ctgaaggaac aatatgacgg tgtcatttgg ctggagcata 232861 tcacgccctc tgtcattatc aagtgagcgg tgtcccctgt ggtaaacagg ggatttttac 232921 atatcgcaaa aataatcaaa acatataatc cgtgatccat tattctaaaa cagaaaggag 232981 attggagcgt gcaatgtatt atgaaaaagc tgtccagaaa acaatcaatt ggattgaatc 233041 acatttacat gagcaaatat caaacgagga tattgttaac gtttcaagct tttcaaaatt 233101 ccattttcat cggatttttc aaaaagaagt cggcatgtcg gttgcttctt atattcggtt 233161 aagacgtctt gcgaatgcgg cggcagcttt gctttataca gatcatcgta ttatcgatat 233221 tgctttgtat tatcagtttg aatctcaaga agcatttacg aggacgttca aaaagatgta 233281 tcacatgccg ccaggagcat accgaacatt tatgaaacgc tttacttcaa aaaaggagga 233341 atcttacatg gagaaaaaaa tgaaaggctg ggtattgagc gggagccatc cgttccaatt 233401 cgaaatgggg attgaccggg aaaatgtaca tcagggaaaa gcttcagggt atttaaagtc 233461 aacgatggtt caggatatcg gtgaatttgc gacgatgatg cagcaattca aagcagatcg 233521 ctatctagga aaaaggcttc gtctatcaag ttttatcaaa acaaaggggg tgcagcattt 233581 tgcctcactt tggatgcggg ttgacagtgc tgctgatgat gttctccaat ttgataatat 233641 gagcaacaga cctattaccg gaacaaccaa ttggaatcat tatgctatcg ttttagatgt 233701 cccagaaaat agcgctgtga tatcttttgg cgttcaatta tctgggccgg gtcaggtgtg 233761 gatggatcat gttgtttttg aagaggtaga tgagagcgtt ccttcaacaa accttgaaat 233821 gccgggagaa cttttagatg aaccggtaaa tttatctttt gaagaggaac tacaaaaata 233881 gttttcagac aactactttt attagtgagt taatggaaaa tactatttgt tattaataaa 233941 cccttgtgct gcttaggttt gtaagagctt ggatattttt atcagtctgg gcggatctgt 234001 tcatctttgc ggcattttcc tgtatgatat agtaagagtg tgcatagcaa ctaactataa 234061 ttgaacaggg tgtttaaaac atggaaaaac aatacagagt attactttac tataaatatg 234121 ttccgattga agatccagag gcgtttagag agcagcatct ggctttttgt aaggagcttg 234181 gtttgttagg ccgtatcctt gtttcttctg aaggaattaa cggtacggta tcaggtacgg 234241 ttgaacagac tgaaaaatat atggaaacaa tgaaagctga tcctcgcttt gcggacatgg 234301 tatttaaaat tgatgaagca gaaggccatg ccttcaaaaa aatcttcgtc cgccataaaa 234361 aagagcttgt aacgcttcgt cttgaagatg atgtcgatcc gaacgaaaca acaggccagc 234421 atttgaagcc tgcagaattt tatgagaaga tgcaggatcc aaacacaatt gtcatcgacg 234481 cgcgtaacga ttacgagtat gaccttggcc atttcagagg tgcggtccgt cctgacatcg 234541 aagccttccg tgaattacct gaatggattg aagagcacaa agatatgctt gaaggcaaaa 234601 agattttaac gtactgtaca ggcggcgtgc gctgtgaaaa gttctcagga tggctggtga 234661 agcaaggctt tgaagatgta gctcagcttg atggcggaat cgtgacatac ggaaaagatc 234721 cagaggtgca aggcaagctt tgggacggcc agtgctacgt atttgatgaa agaatcagcg 234781 tgcctgtcaa ccgtgtcgag catgtgattg tcggcaagga ctactttaca ggagaaccgt 234841 gtgagcgtta tgtgaactgc gcaaatccat cttgcaataa aaaaatgata tgcacaccgg 234901 aaaatgagta taaatatatg cgcagctgca gccacgaatg ccgcacgaac ccaagaaacc 234961 tgtatgtgaa agagcataat atgacagaag aagaagtaaa cgcaagactg gcagcgattg 235021 aaacagaaga tcacgctgct gctgaataaa aaaagaacac ctcgtattga ggtgttcttt 235081 ttttctatat gctttcagtt tggctgtttg cggaaaccca ttctttttgg cggaaggcct 235141 tttcccattt tgataccacg atacaggcga tcgcatgtcc cggtacgttc acgcctgttc 235201 tcgccatgtc catgacgcgg tcaacacccg cgataatggc aacgccttca gccggcagtc 235261 ctacagcatt ggcagtcgcc agaagaacta caagcgatcc tgagggtaca gctgcaatgc 235321 ctttactggt catcacaagc acaagcatca tgagcagctg ctgggacaat gtcatgtcta 235381 cttgaaaggc ctgtgcgaga aagatacaag aaaccgataa atataagctg gagccgtcac 235441 agttcaatga caagccggag ggaacgacaa atgataccac tcgtttggga cagccgtatt 235501 tctccattct atccatcagc tgagggagaa tggtttcagt gcttgtggtg gaaaatgcaa 235561 ttaaaaacag atcccatatc attttcaata cttcgaaata cttaatctga aagatgagac 235621 cgacaagcgg aaagaggaca aagaggatca ggaacaggcc aaggaatacg gtgccaacca 235681 gcttaaacat agggaggagg agttcaatgc catattggcc tacagaagca gccatcaggg 235741 ctaacacgcc gataggagca gtgaccatga cgatttgcgt gagcttgaac ataatctgag 235801 ctgtagattc aaaaaacttc attactggtt cagaagcttt gccgatacca gctgcggcga 235861 caccaaataa aatggcgaag aaaataacgg caagcaaatc atttctggcc atgacatcaa 235921 taatgtttgt agggataata tccaggatca tttgcttgaa atcaacaact ttgtctgtgt 235981 agccggaaag ttcatgaata tctttttttg ccaaatggga gaggtcaagc ccgacacctg 236041 gttttaagac attcgctaat aaaagtccaa gccctaatac caacgttgta atcacttcga 236101 accaaatgat cgtcttgatg ccgagactgc ccattttttt catgcttccg cttcctgcgg 236161 ctccaatgac aatggtagaa aatacaatcg gcacaacaat cattttaatc aggcggataa 236221 atccatctcc gacaggcctc agtgccatcc cgaaatcagg aaaaaagtgg ccgatcaccg 236281 cgccgacagc caaagcgatt aaaatttgaa acgcgattaa ttttttcaaa tgaatccccc 236341 tttagaacga tagaatgtag gcatattcat atcattcgtg attcaaatgc aaacaccttt 236401 tttcaagtta ttttattttg acagcgcttt cattatgttg gcgaaaaagt cccccgcagc 236461 aggggggact tttttacttc atttgaatgt gctttagatc ttcttcagag gtatttgtga 236521 aaataaccgg tgttatggct gaagcggcat gctgcttgat gtaattgaga tcaaaggtga 236581 gaagcagttc gccttgtttg acggcttgtc cgcttgtgac atgtgcttca aagccttccc 236641 cattcagttt gacggtatcg atgccgacat gaatcaggat ttcagtgccg ccggcgctca 236701 taaagccgat ggcgtgtttt gtcggaaaaa tcgagacgat ctcgccgtcc gcaggtgcaa 236761 cgacttttcc ttctgatggt ataatcgcaa atccctcgcc catcattttt tctgaaaaga 236821 cctgatcagg cacatcccct aaagagactg tttctccttt aatcggataa ataaaggtct 236881 catcggaatc gggcttcagc ggtttgtcag ttaccgtgtc cagcgcggcg gcggtggcag 236941 ggacgcctcc ggccatgatt gttttgatgt cgtcttttaa ggcatcggac ttggttccga 237001 atattgcctg gaagttgttg ttgacctcca gcacacctac tgcaccaagc cgttttaatt 237061 catccttgca gacttggctt ggctgatgaa cggtcacacg aagccttgtg atacatgcat 237121 ccaggttagc gatattttgc tgtccgccca aggcctgcag cacgtgaaag gcaagctggt 237181 cttttgcaac tggagctttc tcctcattct gaccgtcttc atctgtctca cggccgggcg 237241 ttttcaaatt ccatttcaga atcgcaaatc ggaacaaata ataataaatg aaagcaaaca 237301 cgatcccgac aggaatgaca acccagccgt ttgtagacag tccgtagttc aagacgtagt 237361 caattcctcc gcctgagaac gtatagccgt ggcggacatg gaataaatca caaacgacaa 237421 agatgacgcc ggcaagaata gagttaatca aatagagcac gggcgcaacg aacaagaaag 237481 aaaactcaac cggttctgta attccggtca gcatagatgt gagcgccgca gaaatcatca 237541 cgccggagat catttttttc ttttccggac gcgcggtatg gataatggca agagcaacgg 237601 ccggcagaca gaaaatcatg taagggaaat cccccatcat aaagcgcccg gctgtcgggt 237661 ctcccgcgaa aaaccttgtc aggtcgccgg ttacggtgtt gcctgttgat gggtctgtgt 237721 attctcccat cataaaatag aaaggcgtat aaaaaatatg atgcaggcca aaaggaatca 237781 gcaaacgata gatcgttgca taaaagaaca ggccgactgt tgaatcggca attaaactgc 237841 tggctgcgtt aattccgttt tggatcagcg gccaaacgaa tgagaaaatg acgccgatca 237901 ccaatgaact gacggaagta atgatcggga caaagcgttt tccagagaaa aatccaagga 237961 ccggatgcag ctcgattgat gaaaatcgct tatataaata ggcggcgaga agcccgataa 238021 tgattcctcc gaaaaccccc atatcaatca ggtgctcggc tccttcatac ggaggctgaa 238081 ggccgagtaa ttttcccata ttgtcgaggg tgacggttaa aattaagtat ccgatgacag 238141 cggcaagtcc ggctacacct tctccgccgg ctaatccgat cgcgaccccc acggcgaaaa 238201 tcagcggaag gttatcgaat acaacgccgc ccgcatcctt tataataggg atgttcagta 238261 aatccttgtc tccgaaacgg agcaaaagac ctgctgccgg caggacggca accggagtca 238321 tcaacgcgcg gccaagctgc tgcagaattt gaaatgcctt tttaaacatg acagtctcct 238381 tttattgtgt tatgagaatg atgcactctt taatttttga gctgctttat aatcggcgat 238441 aacggttaca tgattgtgtt tttgaagaat ggaggctggt acatctgtcg tgacaggacc 238501 ttcagccatc ttttgaatgg cgtctgcttt ttcctcgccg cttgctaaaa gcacaatatg 238561 tttgctgaat tccatgatgg ttttaatgcc cattgaaatc gcgagtctcg gaaccagcac 238621 cggatcgccg ccgaagaatc tggcatttgc ctgtatcgtg ctttccgaga gcttcacaac 238681 acgtgtccgg tcttcaaaat cagatcccgg ttcattaaaa ccgatatggc cattggcgcc 238741 gatgccgaga atttggacat caatgcctcc cgcctggcgg atgagatcct cgtatacttt 238801 gcatgccgcc tcaagctgcg gattgtctcc ttgcgggata tgaatatgat caggctgcat 238861 attgatatgc tgaaaaagat gctcatgcat aaaatggtta taactttgcg gatgagatgg 238921 agagagacca gcatattcat ccaaattaaa tgtagtaacc tttgaaaaat caatttcgcc 238981 tgcctgatag tctgaaatca actgcttata caagccgacc ggtgtgcttc ctgttgccag 239041 gccgagaacg gcatctttct tagcttgtat ttgttcttta ataatggcag cgcttaactt 239101 acagagttct tcgtagtgct cggcgatcag aatcttcatg tgacaccccc tcaaagagat 239161 agacaagcac catatttgtt atgaccaatt tatgatactt gtcattacga atttagcacc 239221 gcccttatca aactgtcaat attaatttct gaaaatttgt tataaaagaa ggatacaaat 239281 ctttcatatt gggagggcaa atggtattat ggtctcaatg aaaaagaacg gattgcatac 239341 agaatgggga gaatgaaatg acagctttat attctgttat caagtttaaa atcattgagt 239401 taattaaatc gggcaaatat caggcgaatg atcagctgcc gacggagagt gagttttgcg 239461 aacaatatga tgtcagcaga acaactgtga gactggctct gcagcagcta gagcttgagg 239521 gatatattaa aagaattcaa ggaaaaggga catttgtatc ggcggccaaa atacaaacgc 239581 cgattccgca taagattacg agctttgcag aacaaatgag aggacttcgt tctgaatcaa 239641 aagtgcttga gcttgtggtg attcctgccg atcattccat cgccgagctt ttgaaaatga 239701 aagagaatga acctgtcaac aagcttgtca gagtcagata cgccgagggg gaacctttgc 239761 agtatcatac ctcatatatt ccctggaagg cggcaccggg gctggcgcag gaggaatgca 239821 ccggctcgct gtttgaattg ttaaggacaa aatacaatat tgaaatcagc aggggcacgg 239881 aatcgatcga accgatttta acggatgaaa cgatcagcgg acacttatta accaatgtcg 239941 gagcgcctgc gtttttatca gaatccctta cctatgataa aaatgaagaa gtggtggaat 240001 atgcgcaaat tattacacgg ggagaccgaa cgaaattcac cgtagaacag tcatatcatt 240061 cataaagcaa tgtgttttaa gaagggaatg gtggttctat gtttttattt acgaatggaa 240121 aagtgctgtg gggagcagtg attgctgcat tcatcctttc aattgtattt tacccttttc 240181 tgccgacgca gatgccgatt cattatgatg ttgcgaacag tccggatctg acggttaaca 240241 agctggcggg gactgtgatg ctgcctgttt tgatggtggt gtttgcatgg gcgcggaaga 240301 tcaattggca atttgtattc gcagtgtata ttttgctgat ttgccacatt gtcgtccttt 240361 gtttagcgct ctaaatcaaa cagccagaat aaaactggct gttttcttta atttcagctt 240421 catctgacaa tgaatgtggt gtataatagc tgatgatcct aaagaatatt ctgaaattta 240481 taggtgtgaa gcggcgtatt attaaaggaa aggctgtata ctttttgcag ctttaaaaag 240541 actgaatatt taaacaatta tgtgaaaggt gtgctgatta gattgaataa gcttattgaa 240601 cgagaaaaaa ctgtatatta taaggaaaag cccgacccgt cttccttggg gtttggacaa 240661 tattttacag attatatgtt tgtgatggac tacgaagagg ggattggatg gcatcatccg 240721 agaattgcgc cgtacgcacc gcttacgctt gatccgtctt catctgtttt tcattacggc 240781 caggctgttt ttgaaggatt aaaagcatac agaacagacg acggcagggt gctgctgttc 240841 cgtccggatc aaaatatcaa acggctgaac agatcgtgtg agcgcatgag catgccccct 240901 ttagacgaag agctggtgct tgaggcattg acgcaattag ttgagctgga gaaagattgg 240961 gttccaaagg aaaaaggaac gtcactgtat attcgtcctt ttgtcattgc cacagaaccg 241021 agtctcggtg tgaaggcatc caggagctat acatttatga tcgtgctttc gcctgtcggc 241081 tcctattatg gcgacgatca gctgaagccg gttagaatct atgtcgaaga tgagtatgtg 241141 agggcggtca acggaggagt cgggtttgca aaaacggctg gaaactatgc cgccagtctt 241201 caggcacagc ggaaagcgaa tgaactgggc tatgaccagg tactgtggct ggacgccatc 241261 gaaaagaaat atgtggaaga agtagggagc atgaacatct ttttcgtcat aaacggggaa 241321 gctgtcacac ctgctttaag cggaagcatt ttaagcgggg ttacacgtgc gtctgcgatt 241381 gaattgattc gaagctgggg cattccggtt cgtgaagaga gaatatcgat tgatgaggtg 241441 tatgcggcct ctgcacgcgg agaattgaca gaggtctttg gcacaggcac ggcagcagtc 241501 gttacgcctg tcggtgaact caacatccat ggaaaaacgg tgattgtagg cgacgggcaa 241561 atcggggacc tctcgaaaaa gctgtatgaa acgataacag atattcagct tggcaaggta 241621 aaaggcccgt ttaactggac agtggaagtg tgaaaatcga aaaagaacct gcccggaggc 241681 aggttctttt tattttgaat gagtcatatc agcagccggc tggcttttgc ggttttttac 241741 ataatatatt gcatagcaaa tggccataaa tggaacgccg caatagagtg cgattctttg 241801 attcggatca aaggcaatgc caacgacgga agccaggcat aacaggaacg cagcaatcgg 241861 cacgaacgga tacaaagggg ttctgtattt caaatcagta accttgtttc ccgcttcgat 241921 ataacgtttt ctgaacatga attgagaagc agcgattccc atccacacga caacgacggc 241981 aaaaccggaa atcgacacga gcacaacgta tacagtgtct ggcgcaaata cgctggacag 242041 caacgacaga atgccgccga tcatgctgaa caccagcgcg ttaaaagggg ttccttttga 242101 cgtcagcttt gcaaatgtcg gatgaagcgt tttttctttt gataaagacc acagcatccg 242161 ggaagaagcg tagagtccgg aattagccgc tgacaggatc gctgtcagga taacaaagtt 242221 catgatatcg gctgcgtatg gtacaccgac tctgtcaaag acagcgacaa acgggctttt 242281 gatgacacct gcatcttgaa tcggaatcag ccctgacagc acaaaaattg ttccgacaaa 242341 gaagagcgag agacgccaga ccgttgtttt tatcgctttt ggtatcgtct tgtcaggatc 242401 aacgctttca ccggctgcga ttccgattag ttccgttccc gaaaaggcaa aattgacgga 242461 cagcatcgtc atcaaaatcg ggacaaatcc attgggaaaa agcccgcctt ccgccgtgaa 242521 gttggacagc atcggagcgg cttctccgcc tttgatcggg atgatgccga acatggcaga 242581 gccgcctaaa agaataaata atacaatggc taatactttg atgctggaaa accaaaattc 242641 tgattcagcg aaaaacttga ccgaaaatgc gttaagcaag aagatgaaca gcgcaaagac 242701 ggcactccac atccaaaccg atgtatgggg gaaccagcgc tgcattaaca ggccggctgc 242761 tgtgaattct gatcccaatg ccacggtcca tgtcagccaa tacagccaag cgaccgtaaa 242821 tccggtgccc ggccctatgt atttggctgc ataggtgtga aaggcgccgg tcacaggcat 242881 ggcgactgac agctcaccga ggcatagcat gaccagatag acgatgccgg ccccgactaa 242941 gtaggcgagt atcgttccgg ccgggcctgc ttgctgaatg gtataacctg agcttaaaaa 243001 cagcccggtt ccgatgacac ctcccaagga aagcataaag aggtgccggc ttttcatact 243061 tctctgaaag gttgtctcat tcttgttgtg ggcagagttc atctttttcc aactttctat 243121 cagcgattta tttccttcct aataaaaaat ctcatgtcag aaagtgacac gagactccgg 243181 cgaaccggct ttaagttaga atatacaaac tattccgata agtcaagttg tttttaaaga 243241 gcgggcccaa gccgcaattt cttgaatatt ttcgggtttt gtccggcagc agccgccaat 243301 cagcctcgct cctttttcat gccaggtgcg ggcgctcgcc ccgtaagatt ctgcgcatgc 243361 tgcgccgttc cacgtttttg tttccggatc atattgctca cctgaattcg ggtagacaat 243421 gatcggtttt gacgtgttct tttttaactc ctctatcaag gaagggatat gctgaagcgg 243481 cgtgcagttg atgccgagtg ctgcaatttg gcggtgttca tcaagccacg atgcgcagtc 243541 agctgcaggt gttccgtcac tgatatgcaa gccgtcttta gcactgaagc tgatccatgc 243601 atacgtttca ggaaattcct tcaacagccg aacaatcgct ttggcttcag tcagacacgg 243661 aatcgtttcg catgccaata catcagctcc ggcttcaatc agcgccttca tccgggggcg 243721 atgaaattca atcagttcat cttctgatat tgcgtagttg ccgcgatact cagacccgtc 243781 tgcaagataa gcgccataag ggcctataga agccgcaatg atcggttttg gccgattcaa 243841 acggttctct tcaagcgacc aaaattcatc acgtgcttca gctgcgatgc tgacggacaa 243901 ctcgatgagc cggcgtgctt ccgcttcgct cagcccgcgt gcggcaaagc cttcaaatgt 243961 agactgatag ctggcggtga ttgcacaatc ggcgcctgcc gcaaaataat cagtatgaac 244021 ttgtttaatc agctccggct cttccatcag gatttttgcc gaccacagac tgtcattcaa 244081 attacagccc ttgcgttcaa gctcggtcgc catggcgccg tctagcacaa taagcgggta 244141 tgtatctaat atgtgttgga taggattcat agaatgtacc gatgccttct ttcagatttt 244201 tttgaaaaag atatgaaaat cgtaatggag gcttacgtgt ttgtcaataa acgcaaaaag 244261 agaaaggtgt tcagcccata tgtctgaaca cccttttctt atgatatttg tttgttgtgc 244321 gtgtcagtct ttgtgtctga aaccggccag cactcaatgc cattatggtt tttgagcaca 244381 tctttataaa agaccggatc cttgcctgct tttttctggc gtgtatagtc tttcagcgcc 244441 gtaaaaacga cctttgatag taagaaaatc gcgattaaat tcacgatgac catcaaaccc 244501 atgaacaaat cagcaagatc ccagacgagc tggactttgg caacacagcc aaacacgatc 244561 attgccagca cgccgatacg gtagacaaaa atcagttttt tgcttttgtt caaaaagccg 244621 atattggttt cgccataata atagtttcca attagagcac agaatccgaa taacaaaatc 244681 agaatcgcga gaaagcctga tgcccatgat ccgacatggg agctgaggga ggcttgtgtc 244741 aaggcgattc cgctcagacc cggagtatga taggcatccg aaaacagaat gataaaagcg 244801 gtgcttgtac aaatgaccag tgtatctgtc agtacaccaa aagcttggat cagcccctgt 244861 ttgacgggat ggcttgttgt ggcggtggca gcggcatttg gtgcgcttcc cattcccgct 244921 tcgtttgaaa agattccccg tctgacgcct tgcatgagtg ccgcgcccaa agccccgccg 244981 gcggcctggt caaaaccaaa cgcatttttc acgattagcg caagcacacc tggcagctgc 245041 gtaatgttgg agaaaatgac gaaaaacgca actccgatat acaggacagc caatacgacg 245101 acaatggatt cagccagctt tgcaatgcgc ttgactccgc caaaaataat cgtgccgaat 245161 acagcaatta aaatgagtcc caatgtcagg cggtttgtgc caaacgcgtt ttcaaaggca 245221 aggctgactg tattggattg aaccgagttg aagacgatac cgaacgataa ggtgattaac 245281 acagcgaaca gcgcgcccat ccaccttttg ttcagccctt tttccatgta atacgccggc 245341 ccgccgcgga agccgtttac atcttttact ttataaatct gagccagtgt gctttccaca 245401 aagctggatg ctgatccgat aatggcgata atccacatcc agaagattgc accgggcccg 245461 ccgagtgcaa tggcgatagc aatgcccgta atatttcccg ttccgacacg ggccgccatg 245521 ctgatgcaaa aggcttgaaa cggagaaatg ctgttttttg accgggaagc agcaccttct 245581 cttaataccc tgaccatttc tttcagcatg cgaacctgta aaaacttaag cctgaacgta 245641 aaatagattc caaaagaaag gagcaaaaca attaatagct ttgaccacaa aagatcattt 245701 gcaataccga cgatatgttc taggatttgc tgcatagaat cacctctttt ttcatgttta 245761 aaaaatgctg agctcccatt cctgcgccat atgcttcagc agcataccgc cagtgaggct 245821 gttgccgtat tcatcaatgg caggcccgta aatgccgatg ccgcatccgg attgaaaagg 245881 ctgttctctt ctggcgcttg gaggcaccag cgccatgatg ccgccggaga cgccgctttt 245941 ggccggcacg ccgacaaacg ccgcatattt gcctgaagcg ttgtacatgc cgcacgtcag 246001 cattaatgcc ttggccaatt ttgccacatc ttttggaatc acctgctcgt gtcgaatcgg 246061 atgatacccg tcatgagcaa ggatcaggcc gatcaacgca atatcttctg tagtgctctc 246121 catagcgcat tgcttcaagt acacctcaag tgtttcttct acttcagctt ctaaaaagtt 246181 tgtttctttt aaatagtagg ccagcgctct gttgcggtgg gcggtttccc attcagaacg 246241 gaatacttct tcatgaattc ttggccgttt tcctatcaaa gtttccatca ccgagtaaag 246301 aaactcgagc ttttcgtatg cagattctcc gggaaggatc gaagcgatgg tgagggcacc 246361 cgcgttgatc atgggattga agggctttcc cggcttgttg atttcgagcc gaatgattga 246421 attaaaggcg tcacctgtcg gctcgacatc tacgcggtca agcacatagg gaatgccgcg 246481 gctcatgcag gcggcaataa agctaatcac ttttgaaatg ctttgcatgg taaaagagac 246541 gttccagtcg ccggcgtgta tcatcgttcc atcaggctcc aatacacaga tgccgagctg 246601 tgaatcattg acttttccta aagcggggat atagtttgcg ctttgtccat tggcggcaaa 246661 agggcgatag tattcaaccc aatcatgaag ctgtaacgcc gggtttatgt ctttctggtg 246721 ctcttttatc aattctttca tcgaattcct cctcactgat ttttttctta aaggactgag 246781 gtgtatcaaa acgaaggcta agggggcgtt aaacgctttc ataatagcgg aaggtataat 246841 tactgtataa tggagactac agaatcatac aaaatacgac aaaaacattt tgaaaataag 246901 cagtaagatt tataaaaacc tcatgttctg ggtcaaaagc aatttgcagg ttttctcccg 246961 attccccaaa ataaaaagcg aggatgtgat caacataaaa ctggaacggt ttattgaaaa 247021 agacggatat atactggccc tcatgctgat tacggtgccg ctggccggtg aactgaaatt 247081 ttatcccctc aatgaagaat tccgggtcag ctttggggca ccggtttttt tcttcttttt 247141 atcattgttg cggcatgtgc ccgctgtgct gccgggtttt ctgactggag cggctgtttt 247201 catctttcgc gtctttctgg aattatgggg cggaggacac aatgggctga ctccgattct 247261 gtatgatcaa gcgtctggct ttttctttta tatgacttac gcctgtctgt tttccatatt 247321 aaaggccaat cgtttccgtg aacggccgat tatgctcggt ttcattgggt ttatgattga 247381 agttgtgtca gattgtgtcg agctaactgt gcaatttctc atttttcata cggttgtcac 247441 gcctgagaaa atcactgaca ttgcggtgat tgcgatttct cacacattta ttgtgatgag 247501 cttttatagt gtgctgaagc tgtatgaaac acaatcgaga gaaaaacaga caaggcagca 247561 gcacgagcac atgctgatga tcgtttccaa tttatatgaa gaaacggtgc acctaaaaaa 247621 gacattgaaa acgacagaga aagtgacaaa cgattcgtat cagctctatc gggaaatgaa 247681 gggcaaggat gttcagctga gcggcagaat cctgagactg gccggagaga ttcatgaagt 247741 gaaaaaggac aaccagcgga tattcgcagg gctttcaaaa ctgatttcga atgagagttt 247801 gagagattat atgagggctt ctgatttgct gcagctcgtg attcgaatga atgaaaagta 247861 cgctgaagca ctagggaagc agattgattt ttactgctcg atcgagggag agcatgacga 247921 atatcacgta tttatcgtgc tttcgatcat taataatcta acagcaaatg cggtagaggc 247981 tatggatgaa gagggaatgg tcagcctgag gctccgtaag ccaaatgaga gtatggtaga 248041 attccaggtg gaagacaatg gccccgggat ttccgagaaa atcggagaca ttgtgtttga 248101 cccgggcttt acttcaaaat atgacgaatt tggcacgcct tctacgggta tcggactttc 248161 ctacgtaaag gaaatcgtga cagagctaga aggggatatc acgtttgata atcagcagcg 248221 gggagtggtg tttgccatca ggctgcctgt ccggcatttg attcagaaag ggtgaaccaa 248281 aagctatgcg tttttttatt gcagatgatg accgtgcggt gcggtcaatt ttaaggcaga 248341 tcattgagga cgaagatctc ggggaagctg ctggtgaagc agacgacgga agccaagtgg 248401 aagggcatat gctgcaattt aagcagattg atattttatt aatcgatctg ttaatgcccg 248461 gaagagacgg cattgagacg attcgtcaga tccagaatac gtactccggc aaaatcgtaa 248521 tgatctctca agtggaggcg aaggaaatgg tcggggaagc gtactcgctc ggcatcgaat 248581 attttatcca taagccgatt aaccgcattg aaattgtcac ggttctccaa aaggtgaagg 248641 agcggatcga gcttgaacac tcgattggag ccattcagca ttctctaagc cggcttgtca 248701 atcggactga acggaaagcg cgtccccagc agaagagtga cagcggttta aaagaggcag 248761 gaacattcct gttgtccgag ctgggcatga tgggagaagg cggcgcacat gatctcatgg 248821 cggtcctgca gtatttagca gaacacgagc aatccgagcc gcacgaaaaa caaagccctt 248881 cgctaaaaca aatattcacc caagtagcgg tacggaagct ggggacagga gcctcacaga 248941 cggaagtcaa tcgcgaaatg aaagcctcgg agcagcgtat ccgcagagcg attattcatt 249001 cgctgcacca ttttgcttca ctgggcacaa ctgatttttc gaatccaaaa tttgaaacct 249061 atgcatcgaa attctttgat tttccggttg tcagccagaa aatgaaagaa ctccaatcca 249121 aggatgcaaa accccttgca cctgctagaa taaatatgaa aaaattcatc cacgtgtttt 249181 ttttggaagc aaagcttttg catgagacga tgaaacaaag aaggatataa accaaacagc 249241 cggctgacca ggctgttttt ttgctgcgca gaatcccggc cggacagtga tttaccgctt 249301 ttttataaaa tatcagaaaa taaagatatt gacttattgt ttatttgtct tacaattaaa 249361 caaaaggata tatgggaagg agcggatgtg aaagaaaaat taataaaagc gcttacagat 249421 agaggccgta tacacaaata acaggaggtt atgttgatga gccgtatcag aaaagcaccc 249481 gctggaattt taggttttcc ggttgctcct tttaacacac aaggaaaact ggaggaagaa 249541 gctctttttc aaaacattga gtttttgctg aatgagggct tggaagcgat atttatcgct 249601 tgcgggtctg gtgaattcca atctctcagc cagaaggaat atgagcaaat ggtggaagtc 249661 gcagtctcgg cagccggagg aaaggtgccg gtctacacgg gggtgggcgg caacctcagc 249721 acagcgcttg attgggcgca gctgtcggag aaaaaaggcg ccgacggcta cttgattctg 249781 cctccgtatt tggtgcatgg cgaacaggag gggctgtacc agtatgcgaa aacgattatt 249841 gaaagcactg acttgaacgc gattctttat cagcgcgata acgcagttct ctctgttgaa 249901 cagatcaaac gtctgaccga atgtgaacag cttgtcggtg tcaaagacgg ggtaggaaat 249961 atggatttga atatcaatct cgtctatacg atcggcgacc gcttgggatg gctcaacgga 250021 atgccgatgg ctgaagtgac gatgccggct tatctgccga tcgggttcca ctcttactct 250081 tcagcgattt caaattatat cccgcatatt tcgcgaatgt tctatgatgc attgaaaaac 250141 ggaaatgacg agcttgtgaa ggaactctat cggcatgtga ttctgccgat caacgacatt 250201 cgcaaacaac gaaaaggcta cgccgtatcc ttgattaaag ccggtatgga aatcatgggt 250261 ttgaatgtaa ggaatacagc cagaccgcct gtcggcccgg ttgaaaaaga tcattatcag 250321 caattggaag caattttgaa gcaggcggct gaccgttttc cgaaaaaagc cgcgacggtt 250381 tgaccagaaa aaacacgaaa ggggcaatgg gcatgtctgt gatcacggaa caaaacacgt 250441 acctcaactt tattaacgga gagtgggtta agtctcaatc aggcgatatg gtcaaagtcg 250501 aaaaccctgc cgatgtgaat gatattgtcg gatatgtaca gaattcaacg gctgaagatg 250561 tggaacgtgc cgtcaccgcc gccaatgaag ccaaaacggc ttggagaaag ctgacgggtg 250621 ccgagcgcgg ccaatactta tacaaaacag cggatatcat ggagcagcgc ttggaggaaa 250681 tcgccgcctg tgcaacgcgt gaaatgggta aaacattgcc ggaagcgaag ggagaaacag 250741 cccgggggat tgccattctg cgctattacg ccggagaggg catgcgaaaa acgggtgacg 250801 tcattccgtc tactgacaaa gacgcgctca tgtttaccac ccgtgttccg ctcggtgtgg 250861 tcggtgtgat ttctccgtgg aacttcccag tggcgattcc gatttggaaa atggcgccgg 250921 cattggtata cggcaatacc gttgtcatca aaccggcgac agaaacagct gtgacatgcg 250981 cgaagatcat tgcctgcttt gaggaagcgg ggctcccggc aggggtcatc aatttggtga 251041 caggcccggg ttctgttgtc gggcaggggc ttgctgagca tgacggtgta aacgccgtta 251101 cgtttaccgg ttcaaatcaa gtcggaaaaa tcatcgggca agccgcttta gcgaggggag 251161 ccaaatatca gcttgagatg ggcggcaaaa accctgtcat cgtagctgat gacgctgacc 251221 ttgaagctgc ggcagaagct gtcataacgg gggccttccg ttcaaccggc cagaaatgca 251281 ccgcgacaag ccgtgtcatc gtacaaagcg gaatttacga gcgctttaaa gaaaaactgc 251341 tccagcgcac aaaagatatt acaatcggag acagcttaaa agaggatgtc tggatgggac 251401 cgatagccag caagaatcag cttgataact gcctgtcata cattgagaaa ggcaaacagg 251461 agggcgcttc ccttttaata ggaggagaaa agctggagaa cggaaagtat caaaacggct 251521 attatgttca gcctgccatc tttgacaatg tgacatctga gatgacaatt gcccaggagg 251581 aaattttcgg tccggtgatc gccttgatca aggtggactc gatagaggag gcgctgaaca 251641 tcgccaatga tgtgaagttc ggtttaagtg catccatctt cacggaaaac atcggccgaa 251701 tgctttcttt cattgatgaa atcgatgccg ggctggttcg gatcaatgca gaaagcgcag 251761 gtgttgagct gcaggcgcct tttggcggca tgaagcagtc gagctcccac tcccgagaac 251821 agggtgaggc agcgaaggac tttttcacag cgatcaaaac tgtttttgtg aagccgtaat 251881 ggtgctggaa agaggcgtgc gtctctttcc cggtttatca caaccagcat atgattctct 251941 actttgaaaa ggagaagata ctatgaaaaa agactttgcg agtgttactc cggcgggcaa 252001 aaaaacgtcc gtgcgctggt tcatcgtgtt tatgctgttt cttgtgacct ctattaacta 252061 cgcggatcga gcgacgcttt ccatcaccgg agattccgtc cagcacgatt tgggattgga 252121 ctcggtcgcc atgggatatg tcttttctgc ctttggctgg gcctatgtca tcggacagct 252181 tccgggcggc tggctgctgg accgttttgg ttcaaagact atcattgcgt taagcatctt 252241 tttctggtcg ttttttacgt tgctgcaagg ggcgattggc tttttctccg ccggcacagc 252301 gattatcctg ctgtttgcac tgcgttttct ggttggttta tcagaagcgc cttcatttcc 252361 cggaaacggc agagttgttg cctcatggtt tccaagctcc gagcgcggga cagcttcagc 252421 cttttttaat tcagcacaat acttcgcaat cgtcattttt tctcctttaa tgggctggct 252481 tacccactct ttcggctggc attccgtttt cgttgtcatg ggtattgcag gcattcttct 252541 ggctgtcatc tggctaaaaa cggtgtatga accgaaaaaa catccgaagg ttaatgaagc 252601 tgagcttgcg tacatcgaac agggcggcgg gctgatttcc atggatgaca gtaaaagcaa 252661 acaagaaaca gaatcgaaat ggccgtatat caaacagctg ttaacgaacc gcatgctgat 252721 tggcgtgtac atcgcgcaat actgtattac gactctcacc tatttctttc tcacatggtt 252781 tccggtatat ttggttcagg cccgcggcat gtctattctt gaagctgggt ttgtcgcttc 252841 cctgccggcg ctgtgcggat ttgccggcgg cgtgcttggg ggcattgtgt cagacatctt 252901 actcaaaaaa ggccgttcac tgacctttgc aagaaaagtg ccaatcattg ccggcatgct 252961 gctgtcttgc agtatgattg tctgtaacta cacagattca gcatggctcg tcgttgtcat 253021 tatgtcgctc gcgtttttcg gaaaaggctt cggcgcattg ggttgggctg tcgtgtcgga 253081 cacgtctccg aaagaatgtg caggattaag cggcggtttg ttcaacactt tcgggaatat 253141 tgcctcaatt acaacaccga ttattatcgg atacattgtc aatgccactg gatctttcaa 253201 tggcgcgctt gtgtttgtcg gcgctaacgc gattgcggcg atcctcagct atttgctgct 253261 ggtcgggccg atcaaacggg tcgtgttaaa gaaacaagaa caagaccccg atcaatcgtt 253321 gcctgtctaa tatttatgaa agcgctttat aaagggagga aaatgcatga gttcaccgat 253381 acaagagcag gttcaaaaag aaaaaagatc gaatattccc tcaatttctg aaatgaaggt 253441 gattcctgtt gcgggacatg acagcatgct gctgaatcta agcggagcac acagcccgtt 253501 ttttacccgg aatatcgtaa tcttaacaga cagcagcgga aatcagggag tcggcgaggt 253561 gcctggcgga gagcatattc gccgcacact ggagctgtca gagccgcttg ttgtcggaaa 253621 atctatcggt gcgtaccagg cgatattgca aacggtcaga aagcagtttg gcgatcagga 253681 caggggaggg cgaggaaacc agacgtttga tttgcgcacc actgtgcacg ccgtcaccgc 253741 actggaagcg gctttgttgg atttgcttgg aaagtttctt caggaaccgg tcgcggcttt 253801 gctgggcgaa gggaagcagc gtgatgaagt aaaaatgctc ggttacctct tttacatcgg 253861 cgaccgaaat cggacgacct tgccgtatca aagcgatgag cagtcagatt gtgcgtggtt 253921 ccgtctgcgc catgaggaag cgctgacgcc ggaggccatt gtgcgtcttg ccgaatccgc 253981 acaggagcgc tatggctttc aggatttcaa attgaaaggc ggggtgctgc ggggagaaga 254041 ggaaatcgaa gctgttaccg cattatcgaa acgttttcca gaggcaagga tcactcttga 254101 tccgaacggg gcatggtcat tagaggaagc tattgcatta tgcaaaggaa agcaagatgt 254161 gctcgcgtat gcggaagatc catgcgggga tgagaatggc tactccgctc gtgaagtaat 254221 ggctgaattc cgccgcgcga cagggcttcc gactgcgaca aatatgattg cgactgactg 254281 gcgggaaatg ggtcacgcga ttcagctcca cgcggtcgat ataccgctgg ctgatccgca 254341 tttttggacg atgcaagggt cggtgcgggt tgcgcaaatg tgccatgatt ggggtttgac 254401 atggggctcg cactccaaca accactttga tatttccctt gcgatgttta cccatgtggc 254461 agcagcggct ccggggcgga tcacggcgat tgatacccat tggatctggc aggacgggca 254521 gcgattaacg aaacagcctt ttgagatttc ttctggctgt gtcaaggtgc cggataagcc 254581 tggactaggc gtcgatattg atatggaaca agtggaaaaa gcgcatgaga tctatcggaa 254641 aatgaattta ggcgcacgga atgatgcgat cccaatgcag ttcctgatca gcaactggga 254701 atttgaccgg aagcgcccgt gtcttgtgcg ataagtttga ttgtaaatat tgtcatatcc 254761 gctattttgt cttacaattg aacaactgaa gggagagttg ttcgtgtacg aaggtttaga 254821 ggatttgaaa gtcgatacag tcaatcggaa aacattagcc aagcaggtca tcgaacggat 254881 tgtccattta ttatcgagcg gacagttgag ggccggagac aaattgccga cagaaatgga 254941 actgatggac attttgcatg tcagcaggcc ggtgctacgg gaagcactca gttcacttga 255001 aacgctgggc gtcattacga gaaaaacacg agggggcaca tatttcaacg ataaaatcgg 255061 catgcagcca ttttccgtca tgcttgcttt ggccactgat aatcttccgg ctatcattga 255121 agcgcggatg gcgctagaac tcgggctcgt gacaattgcc gcggaaaaaa tcaatgagga 255181 agagcttcag cgtttgcaga agacgatcga cgatattgcc aacagcactg acaatcatta 255241 tggtgaagcg gataaagagt tccatcgaat tattgcgtta agcgccaata accccgtcgt 255301 tgaagggatg attcagtccc tgctgatcac ccatgcgaaa attgacagcc aaattccgta 255361 cagggagaga gatgtaacgg tcgaatatca caaaaaaatc tacgacgccc ttgccaaaag 255421 agatccgtac aaagcacatt accacatgta tgagcatctg aaatttgtcc gtgacaaaat 255481 tctaaaagga atggatgaaa aataatggtg agcaaccgca gttgaaacgt aagagctgcg 255541 gtttttttaa accaatttag aaaacgctta ctaaaatatg aggagtgatt ttcatatggc 255601 gatgaacctc aggaagaacc aagcccccct ttacatcaaa gtgcatgaaa tagataacac 255661 cgcgattatt gtaaatgatg gagggctgcc aaagggcact gttttctcat gcgggctcgt 255721 acttgaagag gatgttcctc aaggccataa ggtggccctc accgatctca atcaagggga 255781 cgagatcgtg cgttacggag aggtgatcgg atttgctgat gagacgatca aacgcgggag 255841 ctggatacgg gaagccctcg tgagaatgcc cgctcctccg gcgttagacg atcttcctct 255901 cgcaaacagg gtgccgcagc cgcggccccc acttgaagga tatacatttg aaggataccg 255961 aaatgcggat ggcagtgcgg ggacaaaaaa tatcctcggc atcacgacaa gtgttcaatg 256021 tgttgttggc gttttggatt atgcagtcaa acgaataaaa gaagagctgc tgccgaaata 256081 cccaaatgtc gatgacgttg tgccgctgca tcatcaatac ggatgcggcg tggcgatcaa 256141 tgcgcccgac gctgtcattc cgatccgcac gattcaaaat cttgcgaagc atccgaactt 256201 cggcggtgaa gtaatggtaa tcggattggg atgtgaaaag ctcctcccgg aaagaattgc 256261 ctccgaaaat gatgatgaca ttctatcgct ccaggatcac cgaggttttg cggcgatgat 256321 ccaatccatt ttggaaatgg cggaggaacg gttaatcagg ctgaacagca gaacccgggt 256381 gtcatgccct gtttcggatc tggttatcgg cctgcaatgc ggcggcagtg atgcgttttc 256441 cggcgtgacg gcgaaccctg ccgtggggta tgcggctgat ttattggttc gcgcaggtgc 256501 aacggttttg ttttctgaag tgacagaggt gcgggatgcc attcatttat taacgccgcg 256561 ggctgtcagt gaagaggtcg gacaatcgct gatcaaagag atgaagtggt atgacagcta 256621 tcttcggcgg ggagacgcag accgtagcgc aaacccgtca ccaggcaata aaaaaggcgg 256681 attatccaat gtggtggaaa aagcgttagg ttcggtagcg aaatcaggca caagccccat 256741 ctccggcgtg ctcggccctg gtgaaagagc aaagcaaaaa ggcctgctgt tcgcggcgac 256801 accggcaagc gattttgtgt gcggcaccct gcagctggct gcgggcatga atttgcaggt 256861 gtttacgaca gggagaggaa caccatatgg cctggctgct gcgccggttc tgaaagtatc 256921 gacgcggcat tccttatcag agcattgggc tgatttaatc gatatcaatg ccggccgaat 256981 cgcgacagga gaggccagta tcgaagacgt aggctgggaa atcttcagga cgattttgga 257041 tgtggcaagc ggccgcaaac aaacgtgggc agaccgttgg ggtcttcata atgatttgtg 257101 cttgtttaat cctgctccag tgacttgatt catgttttta tagcggaaag atggaatatg 257161 ctgtaaaatg aaaatcagcg tataggaaac ggaggggtta cagcatggca ttcattagat 257221 tccgagtgac acgaattcaa tagtgaacaa ctctcgcctg aatgcgagag aatcgggatg 257281 aatccgccta tgtatgagcc cttatatggt tatcaaaaaa gagggtggcg tgcctgccct 257341 tttttgtgcc ttcaagcatc ccttctctct actgcaggcc ggagcatgag aaaggggaaa 257401 tgggatgaca aaccttaacg aaaaacagct tatcactgag attgtcgggc ttgcacgcag 257461 ccaaggtttg acggttcatt ctgagaacgc gcaattgaat gaaaccggaa tggactttca 257521 agttgtattt gccaaggacg acacaggtat gccatgggtg ctgcgaaaac cgcggcgaag 257581 tgatgttgtg gaaagagcat ctgcagaagg cataacgctt gcctttctcc gcgcgaatct 257641 gactgctgat gtgccggatt ggagaattca tacaccggaa ttgatcgctt accccatgtt 257701 aaaaggaacg ccggctgctg gaattgactt ggaacaaaag caatatgtat ggaatatgga 257761 tcatcagccg ccgtcagacg actttgtccg cacacttgcc gacatactgg ctgaattaca 257821 tggcacggat caaatatctg ctgggcaatc cggaatagaa gtgataaggc cagaagattt 257881 caggcaaatg acagcagact ctatggttga tgtgaagaat aagcttggcg tatctacgac 257941 gctttgggaa agatggcaaa agtgggtaga tgatgatgca tactggccgg gtttctcttc 258001 tttgatacac ggcgatctcc acccgccgca tatccttatc gatcaaaatg gacgtgtcac 258061 aggacttctg gattggacag aagcgaaggt tgctgaccca gccaaggatt ttgttcttta 258121 tcaaaccatt ttcggagaaa aagaaactgc ccgtttgctt gaatactatg atcaagcagg 258181 cggccgaata tgggcaaaaa tgcaggaaca catctcagag atgcaggcgg cgtatccggt 258241 ggaaatcgcc aagctagctc tgcaaacaca gcaggaggaa cacatcaata tggcgctgga 258301 agcacttggt gtaacatcgg attaagaatt gacttcgttt catgaaccga gtattataaa 258361 ctctacaaat aatagaacgg attaacaatc gtgaggaaga gcaagtacgc atcagaatgg 258421 aggttcagag agtcggtggc aggtgtgaac cgatcctccc ctgatgccga atgggcttct 258481 gaattgcttt gctgaacgga tagtaggcga tgccgggttt ctctccccgt taccaagaga 258541 ggagtatcga aacataggtt ttctgtactt agagtgaacg gctgtatagc tgttaataaa 258601 ggtggtaccg cgagaccctc gtcctttgca taggacgggg gttttttgtg tttcttaaag 258661 gaggtgacgg ccaatgtacg atggctggtg gtggcatagc agatgagtta gaaaggagga 258721 tatcaaatgg tcattgcaac tgatgatctt gaggtcgcat gtcctaaatg tgaaagagcg 258781 ggagaaatcg aaggaacacc ttgcccggcc tgcagcggaa aaggtgttat tctgactgct 258841 caaggatata cgcttctcga ttttatccaa aagcatttga ataagtaaag gagaaaagct 258901 gagctgagat gagagcagaa gagcagagta agattcgtga ggccgcagca ggtacgattt 258961 ttttgctgat cggaacagtt tgttttgcgt ctaaatcgat ttggataaaa tgggcatacc 259021 aaatgggtgc tgagccagat gccgtgctgc tatacaggca gctgctggct gttccgctgt 259081 tttggctgat ttttttaata taccgtcctc caatgccaga cggtaagaaa aaaggagacc 259141 tatggaaggc ttgtggcgcg ggagtgtttt gtttttttct gtctcccttg cttgatttta 259201 tcgggctgaa ccatgtatcc gcaatggttg aacgtatatt gctgatgagc tatccgttgt 259261 ttgtgtttgg attcaccgcg tgtcgtgacc ggaaaatgtc ctcaattcag gaccttttcg 259321 cagttctggc ggtcatgttt gggcttttct tggcgctggg cggctggaat gctgagcttt 259381 tccaggcgaa tatgattgga gctgtattca ttttgttatc ttcggccgtc tatgctggtt 259441 atcttgtcct ttccgggcat ctcgtccatc aaatcggagg gatccgtctc aatgcatacg 259501 ggatgacagc tgctggagct gccatgatgc tttacacagg gataaaatcg gcggctggca 259561 tgaatacgcc aatggcagca tatccgcttt ctatgtatgg tttgttcgca gtaattgcag 259621 tcgttaccac agtgattcca tttgtgctaa tgcttgaggg cataaaacga atcggggcac 259681 agcgagccgc cgccatttca atggcagggc ctatcctgac gattttctat ggagctttat 259741 ttctcggtga acggctcggg ctcattcaag tcattggatg cggtggcgta ttttttgtca 259801 ttacgggcat ggaatacagg aagctgaaaa caggaaaaaa agaataattt ttataaaaca 259861 cacacgtttt tcaattacaa taagtgtaat tacgtgtgtg ttttttgatt ttgtaaaggt 259921 taggtgagga gatgcagcgc atattgcttg tagaagacga ccactcaatc agtgaaatgg 259981 tggatcatta tttaacaaaa gaaggctttg gaattgtgca tgctttcgac ggagaagagg 260041 gcatccggct gtttcagcag ggttcatacg atttggtcct ccttgatatc atgctcccga 260101 agctgaacgg catggatttt ctgaaaatca tccgggaaaa aagcaatata ccggtcttaa 260161 tgatttcggc aaaagatgga gatgtggaca aggcattggg actgggcttt ggggcggatg 260221 attatatcgc caaaccgttt tcgatgattg agctgacagc ccgagtaaaa gccgcgatac 260281 ggcgggcgac gcaatattcg gcagaggagc cggctgtgaa taaggtgatc cggattcacc 260341 agcttgcgat agatatagac aatgtttccg ttttgaaaaa cggagagccg ctccagctga 260401 cgtcaacaga atggcagctg ctgtgcttat ttgcatcaaa tcctaaaaaa gtgtttacga 260461 aagaacaaat ctaccgttcc gtttggaatg aagagtactt tgatgatcag aacatcatta 260521 acgtacatat gcggcggctc agagaaaaga ttgaggatga cccctcctcc cctcaatata 260581 ttaaaacgtt atggggcatc ggttataaat taggagagtt ttagaatgac agtgctatgg 260641 gtggccgctg tcatcgctct ggcgtgtctg aatgtgattc aattcataat gaaaaagaag 260701 cgggacggga atctggctta cacggctgac cagcttagct acatgctcag ccgggattcg 260761 gcaggacaaa ttttgcttcc tacagacgat catgcgctca aagacttgct tgttaacatc 260821 aatcttatcg ttgagaatcg tcagcagatc agcgcccaat ttgccaaaac agagcaatcc 260881 atgaagcgga tgctgaccaa tatgtcgcac gacctgaaaa cgccgttaac ggtcattctc 260941 ggttatattg aagccattca aagtgacccg aacatgccgg acgaagagcg ggaaagattg 261001 ctggggaagc tccgccagaa aacaaatgaa cttattcaga tgatcaattc cttttttgat 261061 ttagcgaaat tagaatctga agataaagag atcccgatca ccaaagtaca tatgaacgac 261121 atatgcaaac gaaatatcct gcactattat gacgctgttc agtcaaaagg ctttcaagca 261181 gccatcgata tccccgatac gccggtgtat gcgcaggcga atgaagaggc tctggacaga 261241 atcctgcaaa acctattgtc caatgcgatt caatatggcg cggccggcaa gttaatcggg 261301 ctgacgctgt cttatgatga gaggaacatc gccatcaccg tatgggatcg cggaaaaggg 261361 attagtgaaa ccgatcagca gcgggtgttt gagaggctgt acacactgga agaatccaga 261421 aataaagcat ttcaaggaag cggcttgggt ttaaccatca caaaacggct tacagaaaaa 261481 atgggaggca tcatatccgt ccaaagcaag ccgtacgaac ggactgcatt tacgatcaca 261541 ttgaaacgca tgacatatta atcgtaagaa tttcttaagg tttgagaaat aaaaatgaca 261601 gggctcgccg ctacaataga aaacaggaaa agagagggaa ggagaaacaa agttgactta 261661 tatcgtacaa acaaacgggc tgaccaaaac atatcagggc aaagaggtcg tatccaatgt 261721 cagcatgcat attaaaaaag gtgaaatcta tggctttctc ggcccgaacg gcgcggggaa 261781 aacaaccatt atgaaaatgc tgacgagcct tgtcaaaccg acaagcggtg aaatcatcat 261841 ccttgggaac aagttcaccc acacgtcata tgaggtgctg gggaacatcg gcagcatgat 261901 tgaatatccg attttttatg aaaacctgac agctgaagaa aatttagatc tgcattgtga 261961 atatatggga taccacaata aaaaagccat acaagaagtg ctggatatgg tgaatttaaa 262021 acaaatcgac aaaaaacccg tcaaaacctt ttccctcggg atgaagcagc gccttggaat 262081 tgcgcgtgcc atcctcacga agccggacct gcttattctg gatgagccgg tgaatggtct 262141 tgaccctctc ggcattaaaa agatcaggca attgtttcaa gtgctgagca aagagtacgg 262201 gatgacgctg ctgatctcaa gccacctgct gggtgaaatc gaacaaatcg cggacacaat 262261 cggcgtcatt cgggacggca ggctgcttga agaggtatca atggaggatg tcaggggcca 262321 gaacactgaa tacatcgagc ttgtcacgcc gaatcagaca agggcctgct ttgtgctgga 262381 gaaagagctg caattaacca actttaaaat attaaatgag aaaacgattc gaatttacga 262441 ggctgaagcc tctcaggctg ccatatccaa agcattgatt ttaaatgatg tagacattga 262501 atcaatgaac aaaaagtata cgtcgctgga ggattatttt atcaaattga tcaacggcaa 262561 tagcatcagt gcgtaaagga ggagagacac gttgatgaat ttgatcagaa tcgaattaag 262621 aaaaatgaaa atgggctggt atatcagagg tgccctcatt gccaacgtga tcattatggg 262681 ttttatgtgg ctgatcagtt attccgaaaa agccgatggc ggggtttcgt tccaaagtac 262741 ggatgaagca ttcctcatca tcggcacctt cgtcagagcg gtatttatcg tatttggcgc 262801 tgtgctgatc gtaaaattgg tgatttcgga atataaaaac aaaaccattc ttgtgatgtt 262861 cacgtacccg atcagccgta aaaagctgct caccgctaag ctcatgatcg cgggcggact 262921 gacgtttatc acgattttac tttcaaatat actcatagcc gccggtttct tttggctgaa 262981 ctcgatctgc catttcatac cgggagagct tacttccgag atcatttctc aacaggcggt 263041 caaaatggcg gttttcgctt ttggcgccgc tggaaccagt ttagttccca tcttttttgg 263101 gatgcgtaga cactcggttc cggcgaccat catttcatct gtagtaattg tgatgctcat 263161 cagctcaaca agtccgggct tctcgatttc atctgttgtg tatatcccgt tatcgttagc 263221 ggcattcggt ttgttctttt cctacatggc gatcaggaat gcggacaagc aggatgcgta 263281 aacaaaggcg cccaatatgt ataaaaggcc gatgctgtca gcaccggcct ttccattatg 263341 agtctgttct tgtttcaaga taatgcttct tgccaatctc tttgctcatc atatagaaat 263401 ggaagcaata ttcaccgatt gccatgacga tcgcgccgaa taaagccgcc aatgcaactt 263461 caccgccagt catccccata gaaagcggca tgcccatcag ccagatcacg agaaaggcca 263521 aaccaaaatc agccaaagtt gcaatcatat tattccattt cggcaataca taaagatcgc 263581 ccagcaaata agaaataacc cctaacacaa tcgtcattag cagcgtatca ccaaacgtga 263641 aaccaaagcc cagaccaagc accagataca acacaataat cgtcataata cctttaatag 263701 cgagcgcttt cacatgtgtc attacaattc ctccttttgt catttgattt gttatgtata 263761 attcctcaaa tgtaaaaagt taaaccttat ttcttttcgg aggcgggtgc aaatctgctg 263821 gggagaggtc aatgatgtga atccaggaat tgaggctgcg gcgcttcgac agcggaaacg 263881 tgaagcttgt actgcaccgg acgctgcttt gatgcccaac agcccattat gtttgctgtt 263941 tttagatgaa taaatttaaa aacttctcct gtccctccgt catcacttct gaagtaatga 264001 aatatgatga aaagagatca aggggaggtg acgtgatggc ggtcgtgaga gcaacgagtg 264061 cggatgtcga tttgatggca aggctgctca gagcggaagc ggaaggcgaa ggcaagcagg 264121 ggatgctgct tgtcggcaac gttggaatta atcggctgcg ggcgaattgc tcagatttta 264181 aaggcctccg caccatcagg cagatgattt atcagccaca cgcgtttgag gctgtgactc 264241 atggatattt ttatcaaagg gcgcgagata gcgagcgtgc ccttgcacgc cggtcgatta 264301 atggtgaaag gcgctggcct gcaaaattta gtttatggta cttcaggccg cagggggact 264361 gtccagccca gtggtataac cagccgtttg tggccagatt taagtcacac tgcttttatc 264421 agccgacggc ggagacgtgt gaaaatgtat ataacacatt ttagagacag gacaccgttc 264481 aaattgaacg gtgtttttct ttgaaaagat gcaatgcaaa atattcctgt gagataatca 264541 aagaaaaaag agctgacgga gatgacagaa tggcaacaat tgacctgcaa aagaaaagtg 264601 taaagatcgt actggagaaa aagcagttaa cgaaggtgac ggctcgtgtt ggactggttc 264661 ttgatattac gggatcgatg agaccgctct acaaaaacgg gacggttcaa aatgtggtgg 264721 agcggatttt ggcagtggct gatcagtttg atgataacgg tttgctggat gtatgggtgt 264781 atgataatga attttcccga ttaaagccag tttcagaaaa ggatttttcg ggctatgtcg 264841 atcgtgaaat tttaaataat gaccgcttgc ataaattcgg cagaaatgat gagccgccag 264901 tcatgaagga cgtgctgcgc aaatatgtta cggaggaacc gagctcgtat cctgctttca 264961 ttgtttttat caatgacggg ggctgtaaaa agtcaatcaa accgataatt gaagcttctt 265021 ctgataaacc ggtgttctgg cagtttgtcg gcatcggaaa cggaaacttt gattttctca 265081 ataaactgga tacgttagaa gggcgtgtca ttgataacac gaacttcctg catatcgaag 265141 agattgaccg catttctgat gatgagcttt atgatgctct gcttgctgaa tttccatttt 265201 ggctgaaaga agcgaaggaa aaagggattg taagagaaca agagcctcct gctgaaaagc 265261 cgaaaaagaa gggctttttc agcagattgt tttcgaaata actgataaag agcactgagt 265321 cattctgcga aatggctcgg tgtttttgtt tttttaagat catgtgaaga aaaataggcc 265381 gaatgggcgg cttgcaaacg acaggatatg cagaaaacgc gtcattcagc cagctttcgg 265441 catgtttcag cagcaggctt gtgagggaag acctgttttt aatgttcagc gcttacaatc 265501 agttcacact tcttcacagt cgtttaacaa tgatttccta taatggagac gatcaatgag 265561 gagagagggg atcttgaatg gcatacgaca gtcgttttga tgaatgggta cagaaactga 265621 aagaggaaag ctttcaaaac aatacgtttg accgccgcaa atttattcaa ggagcgggga 265681 agattgcagg actttctctt ggattaacga ttgcccagtc ggttggggcc tttgaagtaa 265741 atgctgcgcc taacttctca agctatccgt ttacattagg ggtagcgtca ggtgatccgc 265801 tttctgacag tgtcgtgctt tggacacgtc tggcaccaga tccgctgaat ggcgggggaa 265861 tgccgaagca agcagtgcct gtcaaatggg aggtcgcaaa ggatgagcat ttccgcaaaa 265921 tcgtaagaaa aggcactgaa atggctaaac caagtcttgc ccattccgtt catgtggaag 265981 cggacgggct tgagccaaac aaagtgtact attaccgttt caaaaccggc catgaactaa 266041 gccctgtcgg aaaaacaaaa acactgcctg cccctggcgc caatgtgccg caaatgacct 266101 ttgcatttgc ttcctgccag caatatgagc acggatatta tacggcctac aagcatatgg 266161 caaaggaaaa gcttgatctt gtcttccatc tcggtgatta catatatgaa tacggcccaa 266221 atgaatatgt atcaaaaaca ggcaatgtcc gcacgcacaa cagcgcggaa atcattacgc 266281 tgcaagacta tcggaaccgt cacgctcaat accgttctga cgccaatctt aaagctgcac 266341 atgcggcatt cccttgggtt gtaacttggg atgaccatga agttgaaaac aactatgcca 266401 ataaaatacc tgaaaaagga cagtcggttg aagcattcgt gctccgccgc gcggcagcat 266461 accaggcata ctatgaacat atgccgctcc gcatttcctc tttgccgaat ggcccagata 266521 tgcagctgta ccggcacttt acgtacggaa acctggcgtc cttcaatgtg cttgataccc 266581 gccagtacag ggacgaccaa gccaataacg acggcaataa gccgccttct gatgaatcgc 266641 gcaatccgaa tcggactctg cttggaaaag aacaggagca gtggctcttc aacaatttgg 266701 gcagctcgac agcccactgg aatgtgctgg cgcagcagat tttctttgcc aagtggaatt 266761 tcgggacaag cgcaagcccg atctacagca tggattcgtg ggacggctac ccggctcagc 266821 gcgaacgggt tatcaatttc attaaaagca aaaatctgaa taatgttgtc gtactgacag 266881 gtgatgtaca cgcaagctgg gcatcgaatt tgcatgtcga tttcgagaag acaagttcaa 266941 aaatattcgg agccgaattt gttggaacct cgatcacttc cggagggaac ggagcggata 267001 agcgagcgga tacggaccaa attttaaaag aaaatccgca catccagttc tttaacgact 267061 atcgcggata tgtccgctgt acagtgacgc ctcaccagtg gaaagccgat tatcgggtga 267121 tgccatttgt gaccgagccg ggcgcagcca tttccacgcg ggcttcattc gtttaccaga 267181 aagaccaaac cgggttgaga aaggtatcat ccacaacaat ccaaggcggg gtgaagcaat 267241 ccgatgaggt cgaagaggat cgtttctttt cgcacaacaa agcccacgaa aaacaaatga 267301 ttaagaagcg tgcaaaaatc acgaattaag gagtggaaat tatgttttca aacattggaa 267361 taccgggctt gattctcatc ttcgtcatcg ccctcattat ttttggccct tccaagctgc 267421 cggaaatcgg gcgtgccgcc ggacggacac tgctggaatt taaaagcgcc acaaaatcac 267481 ttgtgtctgg tgatgaaaaa gaagagaaat cagctgagct gacagcggta aagcaggaca 267541 aaaacgcggg ctgaatgctg atgaggcaga caccgggtct gcctcttttt ttatgaaagg 267601 gagggctttt ttgaatggat aaaaaagaaa cccatctgat cgggcattta gaagagcttc 267661 gccgccggat tatcgtcacc cttgcggcat tttttctatt tctcatcacg gcttttttgt 267721 tcgtacagga catttatgac tggctgatca gggatttgga tggaaagctg gctgtgctag 267781 gaccgagtga aatcctctgg gtgtatatga tgctttccgg catttgtgcc attgcggctt 267841 ctatccctgt tgccgcgtac cagctgtggc gtttcgttgc accggcgctg actaaaacgg 267901 agcgcaaggt gacgctcatg tacataccag gtttatttgc gttgtttttg gcgggcatct 267961 ccttcggata ctttgtcttg tttccgatcg tgctcagctt tttgactcat ttatcctccg 268021 gccactttga aacgatgttt acggctgacc gctactttag gtttatggtg aatttgagcc 268081 tgccgttcgg cttcttgttt gagatgccct tggtggtgat gtttttaaca aggctgggca 268141 tcttaaatcc ttacagactg gccaaagcga gaaagctttc ctattttctg ctgattgtcg 268201 tgtccatatt gattacaccg cctgatttta tttctgattt tctcgtgatg atcccgcttc 268261 ttgtcctgtt tgaagtgagt gtcaccctat cggcgtttgt ctacaaaaag aggatgaggg 268321 aagaaacagc ggcggccgct tagtgcagcg taccacccgg tgacttcaca tcctcatcat 268381 attgtgcggc cgtaacagcg gcgattctca atgcccggac aatcgtgtcc aggctgaggc 268441 tcggcgctgt tttgtcgatt gtttgctgcg gaatgtaagg aatatgaata aaaccgccgc 268501 gaatgtgtgg ggatgtccgg ctaatgtgat ccattaaccc gtagaacaaa tagttgcata 268561 caaaggtccc cgctgtgtag gaaaccgcag ctggaatgcc gtgttccttc atcttagcag 268621 tcattcgttt cacgggaagc cttgtccagt aagcggcggg cccatctgga gaaatctctt 268681 catcaatcgg ctgatgtcct tcgttatcgg ggattcgcgc atctgcaagg ttgattgcca 268741 ctcgttccgg tgtaatctgc atccgtcctc ctgcttggcc gacacaaatt acgatatctg 268801 gctgatgttt ttgaatggct tggcgcagag tgtccagagc ggatctaaag acggttggaa 268861 tttgttccgc tgtaataatg gcttcttctg tctcgaagcc attaagccgt ttcgccgctt 268921 cccatgatgg attgacggtt tctttgtcaa aagggtcaaa gcctgtgatc agcacttttt 268981 ttctcattct cccatctcct ttttctttta ttctattgtt tatttatggg tttttcatca 269041 aaataatgta aaggagtgaa tcataatgga gcatttgccg gagcagtatc gccagttatt 269101 cccaaccttg cagacgcata cgatgcttgc cagctgttct cagagcgcat tggcagagcc 269161 tgtatcaagg gcgatccagg attattatga tagcctgctg tataaaggga cgaactggaa 269221 agaagcgatt gaaaaaacag agtttgcgag aaacgagttt gcaaagctga tcggggctga 269281 accggatgaa gtggcgattg tgccgtcagt ttctgatgca ctggtttctg tagcatcgtc 269341 cttaactgca tttggaaaga agcacgttgt atatacagat atggattttc cggcggtgcc 269401 tcatgtttgg caggcacact ccgattatac cgtatccgtc attccatcaa tagacggcgt 269461 gctgccgctt gaacaatatg aaacgcatat ttcggatgaa acagtactga cgtgtgttcc 269521 tcacgttcat tatcgtgacg gctatgttca ggatataaaa gcgattgccg agatttctca 269581 gagaaagggc tctttattgt ttgtagatgc ttatcaatca gccgggcata ttcccattga 269641 tgtgaaggaa tggggcgtag atatgctggc agcaggcacc cggaagtatt tgctcggcat 269701 accgggtgtg gcgtttcttt atgtgagaaa ggagctggct gacgcactga agccgaaagc 269761 atcagcttgg ttcggaagag agagcggatt tgatggggct tatgcaaaag tcgcgcgccg 269821 ttttcaaacg ggcaccccag cttttatcag cgtatacgca gctgcagcgg ctttatcgct 269881 gctgaatcat attggggttt ctcatatcag ggatcatgtg aaaacgatct gtgccgatgc 269941 agttcaatat gccgctgaaa aaggcctgca gctggcggcg gcacaaggtg ggattcagcc 270001 gggcatggtt gcgatccggg atgagcgggc atcggaaacg gcggggttgc tgaagaagaa 270061 aaaagtgatt tgcgcgccgc gggaaaatgt tatccgtctc gctccccatt tttataatac 270121 gaaggaggaa atgcggcacg cgattgatga aatcgcggcg aaaacgatcc acaagtaaac 270181 atgaaaaagc ccctgaacac tagtcagggg cttttcatat taatgatcta ctttaacgcg 270241 tttcataaag aaagcgccaa ttaaaccgat aatggcaaca atcattgcaa acacaaatgc 270301 gtgctgtacg cctgctgtca aagcttgcgg gatgactgcc ggatcggcag ggtttttaac 270361 tgtactcata taatcatgct ggcctgcagc cataatgctg accgcaaccg ctgttccgat 270421 agcgccggcc atttgctgca gcgtgttcat aatggcggtg ccgtctggat aaaattcacg 270481 cggcagttgg tttaaaccgt ttgtctgtgc aggcatcatg atcatagaaa tcccgatcat 270541 caagcaggtg tgcaggatga taatcagcac agctgttgaa gtggtcgtga catttgagaa 270601 gaaccatagt acaacggtga caatcacaaa tcccggaatg acaagccatt tcggcccgta 270661 tttatcgaac aagcggcctg taacagggga cataaatcca tttaaaatac cgcccggcaa 270721 gagaacaaga ccagatgcaa atgcagtgag gactaagccg ccttgcagat acatcggcag 270781 aagcagcata gatgacagaa tgaccatcat acaaatgaac accatgatca cacccaaaat 270841 aaacatcggg tatttgaacg cacggaggtt catcataggc tgcttcattg tcagctggcg 270901 gattgaaaat aagataaggc cgacaacgcc gacaatcagc gacacgataa cagtcgggct 270961 ggaccatccc ccggagcctt cacccgcgtt gctgaatccg aatacaatgc cgccgaagcc 271021 aatcgtcgac aggatgatag acaatacatc gattttcggc tttgtcgttt cagatacatt 271081 ttgcatatat gcgataccga aaacaagcgc cagcacaagg aatggaagag agatccagaa 271141 aatccagtgc cagttgagat gctccagaac caatcctgag aaagttgggc cgatggcggg 271201 cgcgaacata atgacaagcc cgatcgttcc cattgcggca ccccgtttat gaggcgggaa 271261 aatcaccaag attgtgttaa acatcagcgg cagtaaaaga ccggttccaa gtgcctgaac 271321 gatccttgcc gctaataaaa acgagaagct cggcgcaagc gccgcaatga atgtacctaa 271381 aattgaaaag ataagtgaca cggtaaaaag ctgtcttgtt gtgaaccact gcaacagcag 271441 tcctgaaaca ggaacaagga taccgagtac aagcaggtag cccgtcgtta accattggac 271501 ggttgccgct gtaatgttca attccttcat aaggtcggtt aacgcaatat tcagcgctgt 271561 ttcactgaac atgccgataa aaccggccaa cagcaaggaa atcataatcg gcatcacttt 271621 gtattgctga gatgctttag ctgttgtttc caaaatcatt tcccctctct atcaactgca 271681 tgtagtatgt cgtttttttt atctcttcag caggtcagga atgcagctgg agatatgaag 271741 gagcggcgta ctgttttttg ccgtcaaaga taaaaggatg ccgccttcaa tcatcgcgtt 271801 aaccacagtg ctggcttctt ttgcacggct ctcgctgcag ccagtctgcc gcagtttttc 271861 ctcatacaca gaggcccatt ctttgtaggc ttcatgacag gcttcgcgca acggttcgct 271921 tttcaatgac gtctcagccg ctagcaagcc cacaggcaag ccttcaatgt cttccgtaca 271981 tgaaaactgg caggagagct ccttcaaaaa ggcttgaatg ccttccgctg gatcggtgca 272041 ggcttccatg cagtccgcga ttttctgacg gatatactcc ttcatctcat tcacggcttc 272101 gatcgcaagc tgttctttac ccccgggaaa gtggtagtaa agagagcctt taggcgcgcc 272161 gctttccttt ataatctggt tcagccccgt gccgtaatac ccttgcagct gaaaaagccg 272221 ggtagctgcc gaaaggattt tctcacggga atctccataa ctcataacat tcccacctta 272281 ctgaattgca atcaaaaata tagtgactgg tctattatct tgattcaatc atcaattgtc 272341 aagaaaaatt cattgtatga aaagacaaaa aaagaaggat atgacaacaa aaaatactga 272401 gagaaaagct gactgatctt ttgactgaat agataaaatg tacaatgatt aatcatcata 272461 tggatgtaag gagagaaata gatgaaaaaa caacgaatgc tcgtactttt taccgcacta 272521 ttgtttgttt ttaccggatg ttcacattct cctgaaacaa aagaatcccc gaaagaaaaa 272581 gctcagacac aaaaagtctc ttcggcttct gcctctgaaa aaaaggatct gccaaacatt 272641 agaattttag cgacaggagg cacgatagct ggtgccgatc aatcgaaaac ctcaacaact 272701 gaatataaag caggtgttgt cggcgttgaa tcactgatcg aggcagttcc agaaatgaag 272761 gacattgcaa acgtcagcgg cgagcagatt gttaacgtcg gcagcacaaa tattgataat 272821 aaaatattgc tgaagctggc gaaacgcatc aaccacttgc tcgcttcaga tgatgtagac 272881 ggaatcgtcg tgactcatgg aacagataca ttggaggaaa ccgcttattt tttgaatctt 272941 accgtgaaaa gtgataaacc ggttgttatt gtcggttcga tgagaccttc cacagccatc 273001 agcgctgatg ggccttctaa cctgtacaat gcagtgaaag tggcaggtgc ccctgaggca 273061 aaagggaaag ggacgcttgt tgttcttaac gaccggattg cctcagcccg atatgtcacc 273121 aaaacaaaca caactacaac agatacattt aaatcagaag aaatgggctt cgtcggaaca 273181 attgcagatg atatctattt taataatgag attacccgta agcatacgaa ggacacggat 273241 ttctcggttt ctaatcttga tgagctgccg caggttgaca ttatctatgg ataccaaaat 273301 gacggaagct acctgtttga cgctgctgta aaagccggag caaaggggat tgtatttgcc 273361 ggttctggga acgggtcttt atctgatgca gccgaaaaag gggcggacag cgcagtcaaa 273421 aaaggcgtta cagtggtgcg ctctacccgc acgggaaatg gtgtcgtcac accaaaccaa 273481 gactatgcgg aaaaggactt gctggcatcg aactctttaa acccccaaaa agcacggatg 273541 ttgctgatgc ttgcgcttac caaaacaaat gatcctcaaa aaatccaagc ttatttcaat 273601 gagtattgaa gaaaagaagg cgaataagcc ttcttttttt tggcttttta ggaccaataa 273661 tgacctctga atcttaaaat ttctttaaaa ataagccaaa attacccttt acttaattaa 273721 tttggtaacg taatataatt ggagaatttg ttacaaaaaa aggaggatat tatgaaattt 273781 gtaaaaagaa ggatcattgc acttgtaaca attttgatgc tgtctgttac atcgctgttt 273841 gcgttgcagc cgtcagcaaa agccgctgaa cacaatccag tcgttatggt tcacggtatt 273901 ggaggggcat cattcaattt tgcgggaatt aagagctatc tcgtatctca gggctggtcg 273961 cgggacaagc tgtatgcagt tgatttttgg gacaagacag gcacaaatta taacaatgga 274021 ccggtattat cacgatttgt gcaaaaggtt ttagatgaaa cgggtgcgaa aaaagtggat 274081 attgtcgctc acagcatggg gggcgcgaac acactttact acataaaaaa tctggacggc 274141 ggaaataaag ttgcaaacgt cgtgacgctt ggcggcgcga accgtttgac gacaggcaag 274201 gcgcttccgg gaacagatcc aaatcaaaag attttataca catccattta cagcagtgcc 274261 gatatgattg tcatgaatta cttatcaaga ttagatggtg ctagaaacgt tcaaatccat 274321 ggcgttggac acatcggcct tctgtacagc agccaagtca acagcctgat taaagaaggg 274381 ctgaacggcg ggggccagaa tacgaattaa tgaaaaacaa aaccttgaag aatgctattc 274441 ttcaaggtta ttctgctttc agcacaatgg ttttcgcagc catatcatga acggtttgtt 274501 ttttcttcgt aaatgcggca gtcaaataga tcaggcggga gaacacatgc acccacgcta 274561 tcaggtaacg gacaatggct tgcgggaagg atattttttt atatgtttcg tccctcacga 274621 tttgcagccc gatgattttt ttgcctagtg tgcccttcca atttgtcagc ggcatcagca 274681 aagggtacac aatcagcatc aatatggcga caataatgac accggcggac ccatcgccaa 274741 acgtaaatcc ggctgccaaa atcactgctg cggcaatgat tacatcaagt aaaagagcgc 274801 aggcgcgcag catgaaacca gctagttcca atagaaacac tccttaaaat gttaaataaa 274861 cacctaatga ttgtaaaaaa gaagggccta aagtgggaat aggtgataag ccttaaatca 274921 caaaagttgg tgaaaatgtc ataggtaaat tggcataatc agccagctta tcacattacc 274981 aaattctttt ttagcccgaa accaagccct cagaagttat ttttgttaaa atagaaaagt 275041 tacaacagaa ttcggagggt ttattgtggg aaaagtgaaa cgaaatgccc cttgcccatg 275101 cggcagcggc aagaaatata aaaaatgctg cggaagtaaa gttgtcgact tcccggcgga 275161 actagcggca aaagaagcga aacaaattca ggaagactta gtggagtatg ccttcacagt 275221 acatagagaa agcatttcag gctttatcaa ccagcatgat tttctttctg ctatggacag 275281 acagacgaaa gacatcagcg tatttaactt aggaatctgg ggaatcttct tccacccgct 275341 tgctggtgag aagacaatct tcgaagagta ccttcagaaa aaaggcgatt cgatcactcg 275401 tccgaaaacg cgtgagatcg tagaatcatg gcagagcatg acgcctgctt tattgctgct 275461 gaaggacctg aaggaaggca tcattcactt tgaagatgtc attacggcaa aacaattcga 275521 agtggaaatg gacgccagca atcaagacct tcctccagtg ggaagcctga ttcttggata 275581 cccaatccac gaagcggaaa aagcagaatt cttcatgcag ttcacgatct tcccggtgaa 275641 gagaacagaa gcgctgatca gcaaggtgaa gaaatatgcg gatgccgctg tgaaggacgg 275701 caaaacgccg gaggacttca tgaagcagga attcaacaac gttctgttcg cgttgttagc 275761 tgagaaagat gaagagccac aagcagagaa agcggaagta agcactgttg agtgggcaaa 275821 cgacttggag aaagaaaccg ctgcggctat tgaagaaggc atgagcgggg aagagtatcc 275881 gactgaattg atcccagctg ttattgacat ctggaaaaca ttctgcgaga aaaaatcacc 275941 tgtcatcaga aagccggaag cttttgcggc ggcagttgaa tattatgtaa acgcaatttc 276001 tcttaacggc gcgtccgttt cccaggctaa actggcgaaa aaatacggcg ttagcgcatc 276061 aacgatttcc agccgttaca aagaaattga aagcacgctg caagatgaag cagatcgttt 276121 tgcacaagcg ttatcctcat aatggaaaaa accttgaaaa gccaggcttt tcaaggtttt 276181 tttatttctg aaacggaatt ttgatttcta accggaagat ggggtggcgg taggtaaaat 276241 ccagcctgcc aaaagcgccc ttcaccagtt tttgaatgat atatgtgccc atgccttcat 276301 gagcgccgtt tttcgttgag cggccaaacg attgataaat tgtatcgagc acttttgggt 276361 ccatcccggg agtgctgttt tcacaagtca gtacataaag cccgctgcgc agtgaagtct 276421 ccagtttaat ctctgctttt tctcgggcct ccgccgcgct gtcgagcgca ttttctaata 276481 tgttgccgac caagctgacc tgatcagcag gcgaaaacgg aagggaagaa agcggtgtat 276541 gcatatgcag cgaaacactc acattcgagg cgcgggcttt ttctaaaaaa tcataaagca 276601 cccctgcaac gtacgcgttc tctcctttca aaaaacggtc atattggctg tattgatccg 276661 cccagttttg aatatatgct tgtgtatctg ccttgggctg agctgatttg attgcagtga 276721 tatgtttcat tgtgtcatga ttccggcttc tgacatcaat cagcatttga ttggcgtgct 276781 gttcagcttg agtcagctta tcaatttgat cagaaagcct tgcctgcaaa gcagactgtc 276841 cgatacggag cccttcacac cctgcaaata tcgcgattac acataatacc ggcatgatgt 276901 ctgtgccaat caacaccact cccaccgaca tcacttgaat caccgcaatc cacgcacaaa 276961 gccctgagga acagtgtttc cacacccgct tcgtattcca aatgtacaat cctgcagcag 277021 ctgcgcctaa agcagcggcg agccaagagg cggctgtgct gtgtgaaaaa gcagcagctc 277081 cctgataaca tatgaaacta aataaaatca gataaagaca ttgaaaaagg gtaatcacgt 277141 actaaactcc tcaaaaatag tagttttgaa aataatcaag ctgctgctta gtgatcatcg 277201 cttttttaga cgttccctca aaggaaactg tgaatgaatg cttggtataa gcggaaaaat 277261 gctttatgta atgaatgttg ataataaagg aacgatgcga acgaagaaaa tctttttcgg 277321 gcaggtcgcc tttaatatca tttaatgttt gatacgtttg cacctcttcg gcggttgtca 277381 caatcgtcgt cgaacgtccc gtccgttctg cgaaaataat atccttcttt tgcaggacgt 277441 gcatttcaga cttttgcttt atcaatatac gcccattcaa actcgtttcc gttttctttt 277501 tcaagtaccg gtcgaaggaa gcggccagac ggtcggcata gtacggcttc ataatataat 277561 catggacgtt caggtcaaag gcgtgaaccg cataaccgcc gtggccggta acaaaaatca 277621 catccacatc aagtgaatgg gatttgatca aatcagcaag ctcgtagcca gacatatggg 277681 gcatctcgat atcggcaagc agcagatcaa tgtctccgtt ctttacccgc ctgtaggctt 277741 ccttcgctga atcggtggaa aagacaattt cgacgtcctg cattctggac acgatcgctt 277801 ctaacttctc taaatctact cgataatcat ctacaagtcc gacttttacc attatcattc 277861 ccctagttac atagaatcat ctttattcta tcccatttca cgacataaaa agaactcttc 277921 gcgacaactt tatccaacta atccagcttt tcgtatatag tcattactag aaataaagat 277981 aagggagatt gtgacatgat tacactgacc gattgcagcc gcaggtttca ggataagaaa 278041 aaagtagtca aagcggtgcg agatgtaagc ttaacaattg aaaaaggaga agtcgtcggc 278101 attctcggag aaaacggtgc cggcaaaacg acgatgctga gaatgattgc ttccttgctt 278161 gaaccatcac agggtgtaat cacagtagac ggctttgaca cggtcaagca gccggctgag 278221 gtcaaacaaa gaatcggtgt cttattcgga ggagaaaccg ggctttacga caggatgacc 278281 gctaaagaaa atctccaata cttcggcagg ctgtatgggc tgaaccgcca cgagatcaaa 278341 gcaagaatag aagatttatc gaaacggttc ggcatgcgcg attatatgaa ccggagagtg 278401 ggcgggtttt cgaaaggcat gaggcagaaa gtcgccattg ccagagcgct gattcacgat 278461 ccggacatca ttttatttga tgagccgaca actgggcttg atattacgtc aagcaacatc 278521 ttccgcgaat ttatacagca gctgaaaaga gaacaaaaaa cgattctttt ctccagccac 278581 attatggagg aagtgcaggc gctctgtgac agtgtcatca tgattcacag cggagaggtg 278641 atttaccgag gggcgcttga atcactatac gagagcgagc gcagtgagga tttgaattac 278701 atctttatgt ctaagcttgt cagggggatt tcttaaatgc tgagccatat ttataaaaaa 278761 gaaatgatcg acgctttacg cgacagaaaa acgatattac tcacaatctt agtgccgatg 278821 attatgatgc ttggacttgt ctttttttat gaaagcatgc tgtccgacaa aggggagcag 278881 tacacgctgg ctgtcggcca ttcgcttccg cccgcactgg aaagcaagct taatgagatt 278941 gacgaaatca gcgtaaaaac atttgcaaag cctgaagagg cagttgatga aggaaaagca 279001 gatgcctatc tgaacgtccc gaaagagttc gactcatatg tcaacagcat gacacctttt 279061 aaggttgatg tttacggcaa ttcaatcgat caagggtcgt caaatgccat gcagcttgtg 279121 cagtctgcct tagatcagta caaaaatgaa attgtgcagc aacgtttaac aaataagcat 279181 attgatcaat cggtgatcca gccgtttaca attcagcaaa aggaagcgga tgaggagaaa 279241 gggacttccg ctattatgct ttccgccatt ctgcccatgc tgattctgac ttccattgtt 279301 tccggcgcaa tgccgatcgc tcttgatatc atggccggtg aaaaggaccg aaagtcaatc 279361 gaggcgctgc tattaacgcc agtcagcaga aacaaagtgc tggtcggcaa gtggcttgcg 279421 gtttccactt ttggcgtggc ttcaggtgta tttgctttgg tgtttttgat tttgtccacc 279481 gtgttattta ccgaaaattt aaaaacggcc ttccagctgg gagatcatat gtggagtgta 279541 atcggcgctt cagccttaat cattgtgctc tctgcattgc tgatatctgc gatggagctt 279601 ttcatcagca tcatgtccag ctcggtaaaa gaagcgcaaa gttatatgtc tctcgtcgtc 279661 tttctgcctg tgttcccgat gtttttcatc ttcagcaagg caccgaacca atttgactta 279721 tcatactttc tcatcccgtt tctgaacctg catgcgttat ttaaacagct tttattcggg 279781 atggttgacc cggctaccat tttgtctacg tcaggaacca tcgccgtgct catcgccatc 279841 ttctttttac tagccagagc ctgcttcctg aaagacaaat gggttcttcc aaaataaact 279901 tgcgaaagga gaaatacact ttctcctttt tgtatatcct gaaaaaagaa ggaaaataga 279961 aaaaggatat ctaatacaaa aagtgaccct gcactatttt tcatcaaaat tggtttcaaa 280021 ggagaaggaa caatggatca aacacgtaca ctcggcaaaa cgaagctgaa ggtgaagcgg 280081 atcggattcg gcgcgaatgc ggtcggcggg cataatctat ttccaaatct aaatgatgaa 280141 acagggaagg atttagtgcg cacggcattg gatggcggcg tcaattttat cgataccgcc 280201 tttatatatg gattggggcg atctgaagaa ttaatcggcg aagtcgtaca ggaacgcggc 280261 gtgcggaatg agctcatcat cgccaccaaa ggagctcata aagaagtgga cggcagcatt 280321 gaattagaca atagccggga gtttcttcgc agcgaggtgg agaagagcct gaagcggctg 280381 aaaacagatt acattgattt gtattatgtt cactttccgg atggaaaaac acctctcgct 280441 gaagtggcgg gcactttgaa agagctgaag gatgagggga aaatcaaagc gatcggcgct 280501 tcgaacctcg attatcagca attgcaggat tttaatgctg acggctattt ggaggtcttc 280561 caggccgaat attctctcat acagcgtgat gccgagaaag agcttcttcc atactgtgaa 280621 aaacaaggca tctcctttat tccttacttt ccgcttgcgt ccggactgct gacaggaaaa 280681 ttcacgcaag acacagtctt tgatgatttc agaaaggata aacctcaatt tcagggtgaa 280741 acgtttatcc acaatctcaa aaaagtagat aagctgaaag cagtagcgga ggaaaaacaa 280801 gcggatacgg cacatgtcgc cttggcgtgg ctgttaacga gaccggcgat tgatgccatt 280861 attccaggag ctaaacgacc ggagcaatta caggataacc tgaaaacctt gaacattgaa 280921 ctgaccgaag atgaagtgaa tttcatcagc gacattttca aataaaaaag gaaatagccg 280981 tcatggctat ttccttttgg tgttttattc tttgatgaat gcttcgacta attctgctgc 281041 tctgtaatca tccatatcaa gctgccattg gtcgatgtca tttttcttca ttttcacttc 281101 aactgttttt tcagatgaag caggtccaag ctttttgaat tcctcaggat agacttgaag 281161 cgcgtatttc actgcctctt catagctggc actagagttt ttactgtagt agtctttcac 281221 tttgtcttcg atgcggtctg aaagagaaga tgcatctaca ggtttaactg tggcttcaac 281281 aattgcttcg tctttagaga ttgaagtcgt ttttgcttga atggaagagt ttttgcttaa 281341 tccctcttta atgccgttca cgatattatc aagcgctttg ctgtccgcat atgtgctgga 281401 aaggccggaa gctgagagat aaccgtcttt ggctgattca ttaaaatcat ttacaatttc 281461 atttttgtta gcgccggtga ttttttcgaa atcggcgtta tctttgccga aaagaaggac 281521 atcaacataa gctgataacg cttttgcaga atcttggagc ttatctgccg tcgccaggat 281581 ttttttgtct tttccgtcaa ttttaaaagt aactgatttt ggctttttat caccgtaaga 281641 ttccggcgta tagttaagct cgtattgctt gcctttatct acaacgaaga aaagatttcc 281701 ttcaacggat ttgtcagcgt taatcgtgct gccctgaagc ttttcgctat agtcttcagg 281761 gtctgtgtca gacattttgg tatcaccttg atacaatgtg aaatccatac tgtctacatt 281821 cagcgggtct tttcctgtgt ttttcaccgc gacattgact tttaacacaa gctggtcatc 281881 tgaagtggac ttatcatatt tagacggaag tgtgtaagag acatccttga ttttgacttg 281941 agctatatct gagctttttt ctgtttctga ttctttcttc tccgcgcttg ttttgctgcc 282001 ggaacaagca gctgtaaaca tcatcagcag aagaattagg aaaacagcgt acgttttttt 282061 ctgaaacatt catttttcct cctcaaatgg tttaggaaag gggagtcttt tgtctttgag 282121 aaatggatct ttttgaatgg attagcatca tataaccaaa aaaatcagtt cttttctcac 282181 ggttttcacc ggattttctg gaaactccgc cctcctttgt catgaatgga cctataaaaa 282241 gttacaacgg aattaatttt aagattatta gcttttatat tgaataggtt catcatccta 282301 tttttggtga aaaatgttct ggtaaaactg gtaaactcag aaaactgtgt attttagact 282361 attacttttt gattagttgg agggaactta agaaggatga aaggggccgc ctttgtgaag 282421 aaagagggac tgaaacaaaa agcactggaa atcggccggg tgccgacaca cttaaaactg 282481 gaaattgaag attatggcgg tgatgataaa agagctcatt tttgttgggc agatcctcag 282541 gatgagaata ccggcattat cgtggagctt ggaccggacg gagagctgga atccctttcc 282601 cgtgatattg agcctgaaag cggagaaagg ctgtctgagg agaaactaga ggatatcatg 282661 cgccaatttg tcgagactca tcatccgggg gcactctctg cctttgttcg tgaagaaaat 282721 gaccgtgcat acggcgataa agtgagattt tcatatgttc aaatggaggc tgggcttcct 282781 ctccccatga gcggatttat ggctgatgtt tccttatcag gtgagattgt ttacttccgt 282841 tattacggcg aagcgggcag catcatcaag ccaaagcggg tcgcggatgt tgaagaggca 282901 cttgccttta tcaagaagga cgtggagttc gaccttttgt ttgaggttct ccatcgttct 282961 gtttacaaaa acggagatga tcagccgcat ttggtgtacg agcctgaagg tagggcgatt 283021 accgtacctg cggatttggt tcaagaagaa caagcagttg atgatgacga tgattacagg 283081 gagccggaga gctttcctct ccctttattc gagggcatcc gcgaaaaggc cgatcctgac 283141 agcatgattg gtattgaaaa tgggtttgtc aaagagcggg aagcggattt gggagatggg 283201 agaattggaa tcgtttggcg gaatccggat gaccctgtgt atcagccggc ggataaaagc 283261 atggacagct ggtttaaggg acggactcat caagtgctga aaaccatcta taacaaagaa 283321 accggaaaac tcgaaggcgt catgtcattt atggagaaaa aagggccgct gacagtaacc 283381 ttggcagagt gtgaaaaaat cgcgcttcgc tttctatttg ctttatttcc gaatgccgat 283441 caatatttta ggatcagata cgacgaaaaa gatgaagaag aaaacgcagt cgctggtttt 283501 acgtttgaag cgcattgtca cggagttccg ctccgatttg ggcagatcag aatttgtgtc 283561 agccgccaga cagggtatat caccgtttat atgggaccgg atattgaccc aaataagctg 283621 gcaaccattg atcctgtgcc ggctatttca gttgaacaag ccaagtctat cttttggcag 283681 cattttaaag ttgagcttgg ctgggaaaga gagtacgggg atgatgaaga acacagctac 283741 cggctcgtct ataagccggt gtatccgcat tttatcgatg cacatacagg ggagcctgtc 283801 ttcagcatat ggtgaaacag ccaaaagtca cgcaattgcc tcagatatag aagagagtat 283861 gtgatgaaag taacagaaag aatctcaaaa aacaatgaca ataatagaaa aggacctttc 283921 ttcactttaa atgaagaaag gtctttttat ataataaaca ggattctctt tgtcgtagac 283981 tctttgaaag ggatgacttc attggttaat aaacagctga aaaagaaggc gcaggagatc 284041 ggaaatgtac cgacgcatta tgagcttgag atagaagatt acgaccaaaa gcaaaagaag 284101 tacgggcagg catattttat ctggaaggac cctaaagatc cggaaaagca cattacagtt 284161 gaacttagaa atgacggcgc cttgctcacc ttttcaacaa ctgtccactc cgagacagac 284221 aaaaaacttc cagatgccga gctgaagctg acggctcttc agtttgccgc tgccaatcat 284281 cccggcacat ttatgaattt tcattttcaa ggcaaggaag aaagggggca gcacatccgg 284341 tttgtctata ccaaaatgga gctggggctt ccgattccca attcaggctt tttaattgat 284401 atgacacgaa gcggtcagat tgtccacttt ctatattacg gggaagggca taaagccgaa 284461 gttccgacgg aatttgtagc aaaagagaag gttgtatccc attacttaaa cacaatgtct 284521 tttgagctga tgtacgatgt cattgatggc gaacaggaac caaggcttgt atatgaaccg 284581 attctaccgg gatacagcta tcccgcagat gtagacgaaa ttgtgcccga ccagcatatc 284641 gcagatgaaa gaatagaaaa cacggcgcca ctgccgccgc ttcagaacaa ggaagaagtt 284701 gatatatttg ccttgctggg ttttacctct gatatgcaga aagtcagtga aagagacttt 284761 ggagaacaaa ttggaagcac gtggcgcagg ggcgctgcgc cggagcgtaa ggatttaagc 284821 ataggaagct attttgaaac gagaaataaa aatacaatca aaatgaagac ggataaaaga 284881 accggaaaat taaaagcagc gctttctttt atggactggc ggaacaacct ccaatgctcc 284941 acggaagaat gccaagagat agcgcttcaa tttttgtatg ccctctatcc gagagcggct 285001 gagtttttca gggtgaatcc cgtccgaatt gatgaaagag ggagagtccg caaccatttt 285061 tctgtctggt ataaaggagt gccgctgcgg ttcggcgctg cccgcatcat tgtcaatccg 285121 gaaactgggt tgattgacgc ttttatggcg cctgatattg aacctgaaca attggaagcg 285181 ataaatcaca ggccggatgt ttccgctgaa gaagcgaaag aagcattttt agccgctttt 285241 gatgtgaaac tggaatggca gcctgatttt acagcaggca gtgaccagca ctgcaaactt 285301 gtctataagc cggtttaccc ttcctatatt gatgcgcaca taaggaaaaa gaaaaggctg 285361 tgaggggtgt ctagttagga atcatctcca agtgggggta gtccttgaat cgtttccaat 285421 ccccgcccca ttcgaaaccg agtgtcttag cgatctcgac aacctccagc caatctgatt 285481 ttccgttttg attgccgtca tattccatat cccatatgat gctgccatcc tttttttgaa 285541 gggcgaaatc aatcgctaaa ccatagttat gatacgattc ccctcctctt gcataggtga 285601 caatattccc tttttttgta cgtccctgtt tatataattc atcttgttcc ttaaaggacc 285661 tgaatccttc agtaatgacg acgtcaatgc ctttattcgc tgcagcggct ttgagtgcat 285721 cggcattctg cttcacaatc ggatgaagat ccgaggggac aggcatgtcc tgcaaggcgt 285781 tttgagaatg ccattcatgc cgaatataac taaaacaaag atctagaaga aatagaatac 285841 ataagataac aaatgttttt gcgggtaagt tcatatcggt ctcactttct caagatgtgc 285901 tgaatgttaa cgcttttaag tgattgactc tctctaaaag cgaacagcta tgataaaata 285961 taacataaat agtagcagga ggaaggaggc agaccgatga gagcaaagat tccatcagaa 286021 gaagtagcag taaagctgaa tgaatggtac aagctcattc gcgcatttga agcagatcaa 286081 gcagaagcgt taaagcagga gattgaatat gatttagaag atatggaaga gaatcaggac 286141 ttgcttttat atttttcttt gatggaattc cggcatcgaa tcatgcttga taagctgatg 286201 ccggtgaaag acagcgatac caagcctccg ttctctgata tgctgaacga aattgaaagc 286261 aatcagcaaa aactcacggg cttactggaa tactactttt attatttcag aggaatgtac 286321 gaattcaagc agaaaaattt catattagcg attgaccatt ataaacatgc cgaggaaaag 286381 ctcgagtatg tcgaggatga gatcgaaaaa gctgagtttc tttttaaagt cgcagaagtg 286441 tattatcaca tcaaacaaac gtatttttcc atgaattatg cgagccaggc gcttgatatc 286501 tatacgaaat atgaactgta cggtcgccgc cgggttcagt gtgaatttat catcgccgga 286561 aatttgaccg atgtgtatca tcatgaaaaa gcactgaccc acttgtgcag cgctttagaa 286621 catgccaggc agcttgaaga agcgtacatg atcgctgctg cctattataa tgtcggacac 286681 tgtaagtaca gtctgggtga ttacaaagaa gcggagggct atttcaaaac agccgccgcc 286741 atttttgagg agcacaactt tcagcaagct gttcaagctg tattttcact gacccatatc 286801 tactgtaaag agggaaaata cgacaaggca gtagaggctt atgaccgcgg gataaagagc 286861 gcggctgaat gggaggatga catgtacttg acgaaattcc gcctcattca tgagctgtat 286921 cttggaagcg gcgacctgaa cgtgcttaca gaatgctttg acctgctgga atccaggcag 286981 cttcttgctg acgccgaaga tctgctgcat gatacagcgg aacgtttcaa tcagttggaa 287041 cattacgagt ccgccgcttt cttttaccgc aggctgatga atattaaaaa gaagcttgcc 287101 gagcagcgtt ttcaatagga aatggcagag aactacaggt tctctgcttt ttttgtgctg 287161 ttttcaactc ggaaaaacag ggtattttcc actgcatagt gagaaacaga ggaggatatc 287221 aagtatgtac aaagatttaa ccggaaaaac agcgattgtg acagggtctt caaaaggaat 287281 cgggaaagcc attgcggaac ggttcggaaa ggagaaaatg aatgttgttg taaattacca 287341 cagcgacccg tctggagcag atgaaactct ggaaatcatt aagcagaacg gagggaaagc 287401 cgtctcagtt gaggcggacg tgtcaaaaga agaggggatt caggcgctct tggacacagc 287461 tttagagcat ttcggcacgc tcgatgtgat ggtaaacaac tccggtttta acggcgttga 287521 ggcgatgccg catgagatga gtcttgaaga ttggcagaga gtgattgatg tcaatgttac 287581 cggaaccttt ctgggagcga aagcagcact taaccacatg atgaaaaaca atatcaaggg 287641 caatgtgctg aatatctcaa gtgttcatca gcagattccg cgccctgtaa acgttcagta 287701 ttccacatcc aaaggcggca tcaagatgat gacggaaacg ctggcgctca attatgcgga 287761 taagggaatc cgcgtcaatg cgatagcgcc cggcaccatt gccacagaat caaatgttga 287821 tacgaaaaag gaagagagca ggcaaaaaca attgaaaaaa atcccgatga aagccttcgg 287881 aaagcctgaa gaagtggcgg cagcagcagc ttggctcgta tctgaggaag caagctatgt 287941 gaccggcgca acacttttcg tcgacggcgg aatgacactt tatccatctc agcttgaata 288001 gaagacaaaa cagggggatt gcgggatgaa aacagactgg tggaaggatg cagtggtgta 288061 ccaaatttac ccgagaagct ttcaggacag caatggagac ggaattgggg acttgcgggg 288121 gattatttcc cgtcttgact acataaagga gctcggggca gatgtgattt ggatttgccc 288181 gatctatcct tctccgaatg ttgattacgg ctatgatgtg acaaaccata aggcgattat 288241 ggattcttac ggaacaatgg acgattttca cgagctgctg gaccaggtgc atcagcgggg 288301 attaaagctg gtgatggact ttgtgttaaa tcacacctcg gtcgagcatc cgtggtttaa 288361 agaagcggag ctggacaaaa acagcaaata ccgtagctat tattattggc gtcccggcac 288421 aaagaacggc ccgccgacgg actggctctc aaactatgga tgcccggtct ggcaatacga 288481 agagcacacc ggagaatact atctccatat gaatgccgtc aaacaagctg atttaaactg 288541 ggaaaatccc gaagttcgcc aggcggtgta tgacatgatg aaattttggc tcgataaagg 288601 ggtcgacggt ttgcgaattg atcagctcca tctcatttct aagaaagaat atcttccttc 288661 gtatgaggac tatatcaatc agcaggcaga gccgaagccc tttcagccaa atggcgaacg 288721 aatccatgac tatttaaaag aaatcacaga tgaagtgttt tctcattatg atgtcatgtc 288781 tgtcggagag gtcggcagtg tcacaccgga agaaggcctg aaatatacgg gaacagataa 288841 gcatgagctg aatatgattt ttcactttca gcatatggag cttgatcagc agcccggaaa 288901 agaacattgg gatttgaagc cccttgagct ttctgattta aaatcggttt tgacaaaatg 288961 gcaaaagaag cttgaacatc aaggctggaa tacattgttt tggtgcaacc acgaccagcc 289021 ccggattgtg tccagattcg gagacgatgg ggaataccgc aaagcatcag cgaaaatgct 289081 ggcagccgta atttatttta tgaagggcac gccgtatatt tatcagggag aagaaatcgg 289141 gatgacaaac gcgccgttca cccggattga agactacaaa gatatccaaa cgatcaatat 289201 gtatcataaa cgggtgtttg aaaaaggcta tgatccaaat gatgtgatga gatcgatctt 289261 agccaaaagc cgggatcacg cccggacccc gatgcagtgg aacagcggca aaaatgccgg 289321 atttactgac ggcacgcctt ggctgaaggt caatccgaac ttcaccgcaa tcaatgtgga 289381 ggaagcgcag ggagatcctg attctgtctt aaactattac aaaaagctga tcagcctgag 289441 aaagcagtac gctgacctca tgaaagggag ctttgatctt ttgcttccgg acgatccgca 289501 gttgtttgta tacatgagag aaaacagtaa acaacagctt ttgtcggtca ataatttttc 289561 aaaagagcag gctgtttttc agtggcctaa gaactgcggc aaagctcagg cctcactgct 289621 tctcagcaat tataacaacg atgatcttga tgacgaaatg gtgttccggc cttatgagag 289681 cagggtctat cttctggaca aaacaaacta atgattgaag tagcccggca tttttagccg 289741 ggttttttta gtacatatat tcgctctgca ggcgggaaga ataaatgaaa atgaaattta 289801 ttcttgcaaa acgtaatgac ttcggtttat tatgatatag gattacaaaa tcgttatcat 289861 tttgatttaa agttactgaa aaagagggga tatacgatat gtttaaaaaa tggagcggtt 289921 tgtttgtgat tgcagcgtgc tttttattag ttgcagcatg cggcaactca tcaacaaaag 289981 ggtcggcgga ttcaaagggt gataaactgc acgttgtcac aacgttctac ccgatgtatg 290041 aattcacaaa acaaattgta aaagacaaag gcgatgtgga tctgttaatc ccatcttccg 290101 ttgaaccgca tgattgggaa ccgacgccga aagacattgc caacattcag gatgctgatt 290161 tgttcgttta taatagtgaa tacatggaga catgggttcc gtcagctgaa aaaagcatgg 290221 gccaaggcca tgccgttttc gttaatgcaa gcaaaggcat tgatttaatg gaaggctctg 290281 aagaagaaca cgaagagcat gatcatgggg agcatgagca cagtcatgca atggaccctc 290341 acgtatggct tagccctgtt ctggcacaga aggaagttaa aaatattacg gctcaaatcg 290401 tgaagcagga cccggataac aaagaatact atgagaaaaa tagtaaagaa tatattgcaa 290461 aactgcagga tcttgataaa ctatatcgta caaccgcaaa aaaagcggag aaaaaagaat 290521 ttatcacgca gcatacagct tttggctatc tggcaaaaga atacggcttg aagcaggttc 290581 cgattgcagg gctttcacct gaccaagaac cgagcgcagc cagcttggca aagctgaaaa 290641 catatgccaa agaacataat gtaaaagtta tttactttga agaaattgca tcctcaaagg 290701 tcgcagatac gctcgccagt gaaatcggcg cgaagacaga agtgctgaat acactggaag 290761 gcttgagcaa agaagaacag gataaaggtt tagggtatat cgacattatg aaacaaaacc 290821 tcgatgccct gaaagattca ctattggtta aatcataaga tagtgtgcgc cggaggggtg 290881 cacactattt ctttgtgaga aaggaagatt aacatgaatc tcgtctcatt gaaagatatc 290941 gttttcggct attcccatac gcctgtttta gataaagtat cacttgatat tgaaagcggt 291001 gagttcgtcg gcatcactgg accaaacggc gcctctaaat cgacgctcat aaaggtaatg 291061 ctcggcatgc tgaaaccgtg ggaaggcaca gtgacgatca gtaaaaggaa tacagaaggg 291121 aaacgcctga ccatagggta cgtcccgcag caaatttctt catttaatgc cggatttccg 291181 agcacggtgc tggagcttgt tcagtcaggc cgctatacaa aagggaaatg gtttaaacgt 291241 ttaaatgaag aagatcatct tgaagtagaa aaagcattga aaatggtgga aatgtgggac 291301 ctccgccatc gtaaaatcgg tgatttatca ggcggacaga aacagaaaat ctgtatcgcc 291361 agaatgctcg ccagcaaccc ggatctgctg atgctggacg aaccgacgac agctgttgat 291421 tacgacagca gaaaaggatt ttacgaattt atgcatcatc tcgtgaaaaa tcacaaccgc 291481 acagttgtga tggttactca cgaacaaaac gaagtacagc aatttttaga taaagtgatt 291541 cgattagaga gaggagaaaa aggcggatgg aaatgtttga cttggaattc atgcgacgag 291601 cttttctagc aggcggcatg atcgccgtca tggctccgat actaggagtg tatctcgttc 291661 tcagaagaca ggccttaatg gctgacacac tttcacatat ctcattgtca ggtgttgcca 291721 tcggcttttt tctcagcacc aatataaccg cagcaagcat agtcgtcgtg accatcggcg 291781 cgatcggaat tgaatacatg cggcgggcgt atcggactta ttcagaagtg tccattgcca 291841 tcttaatggc agctggtttg tccttcgcga tgtttttaat cagcctttcc aaaggcacag 291901 ccaatatgag catcgatcaa tacctatttg gatcgcttgt gacagtaaac cagcagcagg 291961 tctatattat cagtattatc acactgctga tcctgcttta ttttattgta ctgagaaggc 292021 cgctctacct gctgacgttt gatgaagcta cagccaaaac atcgggaatc aatacaaacg 292081 ttctctcgtt gtcattcagt attgtcacag gccttgcgat ttcagtcatt attccgatca 292141 tcggggtcct tcttgtatcg gccctgctcg tattgccggc agccttcgcc atcagaattg 292201 caaaaggctt taacatggtt ttcattacag ccatactcat ttcattattc agcgtattta 292261 cgggactgac atcatcctat cagctcggga cgccgccagg tccgtctatt accctgctat 292321 tgatcgtttt gctattaatc ggatttgcag ttcagggagt ttggacgttt atcaaaaaag 292381 aagctcagcg caaaaaaaga agccgataac atgaaaagca gttttcccta gggaaaactg 292441 ctttttttat agaaacaatt cggcaaggcg ctcataagat tcttttttcg cctcaaaatc 292501 aaacacattg cacagaacca tgatttcatt tgtttcgtag cagcctgtga ggtctaacag 292561 ctgttgtttg acagtggtgg gagaaccgat caccatccgc tttctgtttt cttctatgag 292621 ttttttatcg gacgctgtat agggatgagc tttcgcttcc tcgatgcttg gcacgcggct 292681 gtccaagcct tttccgacgc gaagaagcca cagatcctgg cttaatgcga gttcttctgc 292741 ctcttcatct gtttttgcgc aaatgacaaa aatcgtaaac agtgcggatg gattcgaaaa 292801 atgggctgag ggccgaaagc tttcccggta gatgcggaat gcattttctc ctcgctcggg 292861 attaatgaaa tgcccaaata catatccaat cccctggtgc gccgcgcgtc ttgcgctgtt 292921 ttcaccaaga ccgagcaccc atagctcggg tgccgtacca ataaggggcg ccgctttgat 292981 tccggcatac ggatggtcgg gaggaaggga atctgttaga aaataagaga catcctgcag 293041 ctgtctgtta aattcggtta agcttttttt caccccgtcc gttaatgcaa gtctggtttt 293101 tgtcgtgccg ccgggggagc gaccgacgcc gaggtcaatc cggtttggat acagggcctc 293161 aagctggcga aaggtttcag ccactttaaa tgggctgtat tggggcagaa gcacgccgcc 293221 tgatccgaca cgaatggtgt ttgtctgtgc tgcgatgcgg gcgatcatga tttcaggcgc 293281 tgtgcttgcc agtcctttcg tgctgtgatg ctcggcaaac caataacgct tatagcccca 293341 ctgttcgctt aattgggcaa gctcaaccga atgctggaga gttgtcacag ggctttctcc 293401 tttagaaaca ggtgcctgat caagtatgct taaatgaatc aaaaggccgc ttcctttctg 293461 tctgttttta gatggtgaca ccagaatagg caaaatgact tgcccgcgtc aaatggtttg 293521 tttaagaagc gcactttata gcatttgcaa atcatatatc aaatatggaa gttttttttc 293581 gaggtttttc gtcaattatt cttaactttt acgaaacttt gatataataa caaacgtata 293641 tattagtaat ttacggctta ttttccttgt gagcgtaaaa ataaatgtga ctatcttcac 293701 attttgatga gtaggagtga atcgtgtggc aatttcttta gaaaaaggtc aacgaattga 293761 tttaacaaaa ggaaaagccg gtctgtcaaa attgatggtc ggtctcggct gggacccagt 293821 gtcctcaggc ggaggattct tcagcaaact gcttggcgga ggcggtccga atatcgactg 293881 tgacgcttca gtgctgatgc tggaaaacgg aaaattcacc gataagaaaa acctgattta 293941 tttcggcaac ctgaaaagcc gctgcggcgg tgtacagcat acaggcgaca acctgacggg 294001 tgacggtgcg ggcgatgacg agcaaattat gatagattta gataaagtgc ctggaaacat 294061 cgataagctt gtatttgtag tgaacattta cgattgtgtc agaagaaaac aagatttcgg 294121 catgattcaa aatgcgttta tccgcgtagt tgatcaatct aatcacgagg aaatgctcaa 294181 gtacaatttg agagacaatt acgccggcag aacaagcctg attacagcag aaatctaccg 294241 cagcggcagt gagtggaagt ttgcggcggt cggtgaaggc acaaacgata cgagattaga 294301 agatattatc agtcgatacg tataaaagaa aaggagtgga tgaaacatga caatttcatt 294361 ggcaaaagga caaaaagtag atttaacaaa aacaaatccg ggtctttcaa aggttgttgt 294421 cggtttaggc tgggatacga acaagtatga cggcgggcac gactttgatc ttgactcaag 294481 tgtgtttctg ttagacgccg cgggcaaatg cgcgtcacca aacgacttta ttttctacaa 294541 ccagcttgaa ggcggcaacg gttcagtcgt tcattcaggc gacaacctga ctggtgctgg 294601 cgaaggcgac gatgagaatg taaaagtaaa tctcagcgct gtaccggcaa acattgataa 294661 aatctcattt gttattacca ttcacgatgc agaagcgcgc agccaaaact ttggacaagt 294721 atcaaacgcg tttgtccgca tcgtaaatga agaaacaaat gaagagctca tccgttacga 294781 tcttgcagaa gatttctcta ttgaaacggc aatcattgca ggggagcttt acagacataa 294841 cggcgagtgg aaattctcag caatcggctc aggctaccaa ggcggccttg cccgcattgc 294901 aacagactac ggtttgcaag tcggttaaga caaatacgaa gagcagaaag gagagaggca 294961 gtatggccat tcaattatca aaaggacagc gcattgattt aacaaaaaca aatccgggac 295021 tgactaaagc ggtgatcggc ttaggctggg atacaaacaa gtactccggc ggacacgatt 295081 ttgacctgga tgcttcggcc tttttagttg atgcgcatga taactgcgta aatgatctcg 295141 atttcgtctt ctataataac cttgaacatc cgagcggcgg tgtcatccat acgggtgaca 295201 accgcacggg tgagggcgac ggagatgatg agcagattat cgttgatttc tcaaaaatcc 295261 ctgctcacat tgagaaaatc ggcatcacag tgaccattca cgacgctgaa gcacgcagcc 295321 aaaactttgg acaagtttcc aatgcatttg tccgcgttgt ggatgaagaa acgcagaatg 295381 agcttcttcg cttcgatttg ggagaagact tctccattga aacagctgtt gtcgtttgtg 295441 agctttacag acacggcggc gagtggaaat tcaatgcaat cggcagcgga ttttccggcg 295501 ggctggctgc attgtgccgg aattacggtt tgcaagtgta agcgagtgac aaatagagaa 295561 gtcaccgttt caaattatag gaggaaaaaa cttggacttt ttacatcata ttttgtctac 295621 gtatgcttca tttttcgatt ggaaaatgtg gggggaagtt ctgactgatc ctgtttcctg 295681 gggtttgatc ggttcccttg ttgttctgga aggcctttta tcggccgata acgcgcttgt 295741 tcttgcggtc atggttaaac acctgccgga aaaacagcgg aaaaaagcgt taacgtatgg 295801 tttgtttgga gcttatattt tcaggtttat tttcatcggg ctcggtatgc ttctcattaa 295861 attctggtgg atcaaggtgc ttggcgcgct ttacctggct tggctcgtca ttaagcactt 295921 ctggataggc gaaaaagaag aggaagcgga cggcatgaag aaaaactctt ggatggtccg 295981 cacgttcggg atcttctggg cgactgtcat ttcagtagaa ttaatggatc ttgccttctc 296041 tgtggacagc atcctggccg cgtttgcagt atctgaaaaa gtatgggtgc ttctgattgg 296101 cggtatgctt ggtattttaa tgatgcgtac agtggcaaaa gtgttccttg tgctgattga 296161 taaaattcct gagctggaaa acacagcatt cgtcttaatc ggcattatcg cgctgaaaat 296221 ggcggggagc gctttccatt acgaaatgcc gcactctgta ttcttcatta tcattatcgc 296281 tgcatttgcg gtaacattga tcattcacta catcaataaa caaaagcagg tgcgcgaaca 296341 aacagccgct tcaaaagaag aataaaacaa aacaaggagg gaggttcaat gtccttcctt 296401 ttttgttacc gaaatatcgt ttcaatgaca aaccggaaag gaggatatga tgagacaaga 296461 agaactaacc attcataaag cacttccggc tgatggcgat tggaaaagcc tgctgtttca 296521 gccattgccg gagcgggatc actatgaaac tgcacaaggc ctttcttttt ctcgtcttgc 296581 cggtcagata ttgggcacgc ctattgatga gacggactac tataacgagc tgtatgagct 296641 gtctgtaaac gaccgcataa cgattttgag tgaaacgctt gataaaacaa tcgaaccgga 296701 aacatttcaa aagcttcagc atattcattc catcaatcag aaagaaaaag ggctgtcagt 296761 cagccgcttt gttgcctttc tggacgggga aaagctgatt gcgaagcact caaatccctt 296821 gatgcaccgc catttaagaa aagcgttgat gacgctttta catacctttg cggacagtca 296881 tgaaaagggg ctgaatcatc ctgattttcg cagagtgctg cttgatgtct cgaagttttc 296941 cttaaaccat ctgaaccctt ggctggaaaa aaccgatata gagcgggaga tgccgaaggt 297001 tgtttggtat ggagatgcga cgaaaagcca gctctatttc ttatattatc tgatgctggt 297061 cggctgtgat gtactgctgt tccatccggc gggaacggat cagctggcgc ttgtcgaccc 297121 gaagcaggag ctcggtttta cggaaaagct cccggatgtt tcggagcttc agccgtttcc 297181 gaaagaaaaa ccagaccgga aatcaacagt ggcttaccgc tcaacaaagg aaattgaaca 297241 tgtgctgaat cacgaggaat ccatgctata taagccgtgg cagttcagag atcacacacc 297301 ggtgtccgtt acgctgaaaa cgacctatga tgaattgttt ttaatcacga aagaacgcgc 297361 ctttattcgg ccgaatttca aagctgataa acattccatt gagattccga atgtattcgc 297421 caaaattatg ggcgtgtcga aagacaataa ggaatattgg aacaggcttc atactctagc 297481 ggattatcag gaaacagaaa tggtcagaag ctttccattt acagaagaaa taaagtcgaa 297541 ctatcaattt cactacagcc acgcacttga tcaagaaggg aacattgatc cggacaagct 297601 gatggcaagc aatgtgtggc agtacaaaca gctgccggcg ggcgttcaga ctgccattgc 297661 caaaacgatt tcgagaatgt gcaggtaccc gcggcttaaa gccttgcatc aggaacaagt 297721 caaggatgtt caaatctatt tgtttaaaca aacaacaaac ctgcctgcta atctgctgaa 297781 attgattcaa atgttcgact atgcgcaaac cgttccgaaa ctcgttttat atcatacgga 297841 aatgagcggc ggactcacgc gttcggatgc tgccgccctg ctgttcctga atgaaatcgg 297901 aatcgatatc atcatttata atccgcccgg acaccaagat attgagcagt ttattgaaga 297961 ggatcagtat gatatccact ggctggatga catggtgttt cagcaggact acaaagagcc 298021 ttcgcttgtg aaaaggctct tcagaaccat tacccaaaaa taaggagaga agaaaagcat 298081 gacaacagaa aatcaaaatc cgcttgttct cgataaaaat gaagagattt cccagcaaaa 298141 agctgacgat atccgtcttc agctccgtca ggaaccagaa gtgaagcggc ttgctcaaca 298201 aattgacgtc aaaaaccaaa tggagctgct tgagtacggc aaggagccgg ccgttgaaat 298261 atccaagttc tctgaccgca tcttggggat gatgaaaaca acaagcgtga cagactccgg 298321 cacaatgctg actcagcttg ggaaaatcat ggaccgcttc gacaaaaatg attttgatga 298381 gccaaaggga ttaatggcga aaattttcaa acgcggcggc agcatgattg aaaaaatctt 298441 taaaaagtat cagacgcttg gcggagagat tgaaaaaatc cacgttgaga tttcaaaata 298501 caaagatgag atgacgaaga cgaactacac gctcgatgaa atgtatgaaa acaatatcaa 298561 atactatatg gagcttgaaa aatacgtcgt tgccgggcag atgaaactgg aagagatgca 298621 gtcgatcctt ccttcatatg aggaaaaagc ggcaagcggg aaccagctgg cgcaaatgca 298681 gctcgatacg ttgcgcaacg gcattcaggc gcttgaggaa cgggtgtatg atcttgacat 298741 ggcacggatg gtggcgcttc aaaccgcacc tcaaatccgt ctcctgcagc gaggaaatgc 298801 aaagctgatc gggaaaatca actccgcgtt tatcattacc attccgattt tcaaaaacgg 298861 cattattcag gctgttacgg taaagcggca aaagcttgtg gctgattcca tgagcgagct 298921 tgaccgccgg acaaacgaga tgctgaaacg aaatgctgaa aacatctcga gccaaagtgt 298981 tgaaattgcg agaatggccg gcagaccgag catagatatt gaaacgattg aatcgtcttg 299041 gaacacgatt gtcagcggca tgcaggaaac aaaacaaatc gaagaagaaa acaagcgcct 299101 ccgcgaagac ggcgcgagac gaattgccca gcttcaggat aatattaaaa aagcagcatt 299161 gcagcaataa taaaaacccc gcttgtggaa cataagcggg gtatttcaat tacatcattt 299221 agttaatgac aatgtgtaaa gacaggtgta aacttaaacg gtaatcattt tgcatatcag 299281 aggtgttggc aatgggaaaa caacagccta tatcccagcg taaactgctg ggcgtcgccg 299341 gtttggggtg gctgtttgat gcaatggatg tcggaatatt atcgtttatt atcgccgcgc 299401 tccatgtaga gtggaatctg tcgcccgaag aaatgaaatg gatcggaagc gtcaattcca 299461 tcggcatggc tgcgggtgcg tttttgtttg gtttgcttgc tgatcgaatc ggccgcaaaa 299521 aagtgttcat catcaccctt ttatgctttt ccatcggaag cggcatttcc gcttttgtga 299581 cgagcttatc ggcatttcta atccttcgtt tcgtgattgg tatgggactt ggcggcgagc 299641 ttccagtcgc ttcaacactc gtttcggaag cggttgtgcc tgaaaagcgg ggcagagtga 299701 ttgtgctttt ggaaagcttt tgggccgtgg gctggctcgc agcggccttg atttcttact 299761 ttgtgatacc aagcttcggc tggcaggctg cccttctgtt aactgcgctg actgcttttt 299821 atgcgctgta cctgcggacg agtctacctg attcgccgaa atatgaatcg ctttctgcca 299881 aaaagaggtc gatgtgggag aatgtaaaaa gcgtctgggc aagacagtat atacggccga 299941 cggtgatgct gtcgatcgtt tggttctgtg tggtgttttc ttattacggc atgttcctat 300001 ggctcccgag tgtcatgctg ctgaaaggct tcagcatgat tcaaagcttt gaatatgtcc 300061 tgctgatgac gcttgctcag ctacctggct atttctctgc cgcatggctg attgaaaaag 300121 cgggccggaa gtggatactc gtcgtttact tgattggcac agcaggaagc gcctatttct 300181 tcggaacggc ggattcctta agtcttctgc ttacggctgg agtgctgtta tcgtttttca 300241 atctcggtgc gtggggcgtg ctgtatgctt ataccccgga gcaatacccg actgcgattc 300301 gagcaacagg ttcaggaacg acagcagcgt ttggaagaat cggcggcatc ttcgggcctt 300361 tgctcgtcgg aaccctggca gcccgtcata tttcgttttc ggtcatcttt tcaatctttt 300421 gcattgcaat cttacttgcg gttgcttgta ttttgattat ggggaaagaa acgaaacaaa 300481 ctgagctaga ataggaaaag cacctcttaa aagaggtgct ttcagcgtgt cgacaaaccc 300541 tcgcattcgt tgtcaggact gcgcttcggt gctcaatgcg aagtggatca acggctaaat 300601 tctcaggcgt cctgcctaaa cgccgtcgtc atcacatcct gtgaatgtcc gctcctatgc 300661 tcgtccttcc tagacttcaa gggttttcaa tcacgctgaa aagattttgt caacaatctg 300721 aggcacctct tgaatgaggt gcttttttac aattgcgccc gggctgtgga ttggcgtttc 300781 ccggttttac tgattgtctg gtagagcgtc atagaaagta tgaacagaat ggcagtaaat 300841 cctgtgacag ctccgaaatg ctgtgtgctt tgatataaaa aacctgcaat acttgtaccg 300901 acagtggttc cggcatacat agcggcattg gaaagggaag cgatggttcc tcgcgcattt 300961 ggtgcaatgg attgaaagac acccatcatt aacggaaaga tgatgccagc tgtaaagaac 301021 gtgagaaaaa agccggcttc tactaaaaac aagtttggaa agaacggaag agcgaaatag 301081 agagcgccca ttagcagcat cccgctgatc agtgttttaa acatgcccag cttttctgaa 301141 acccggctgc cgataaggct cccgagcata tttcccagtc cgagtacaag catagctgcg 301201 ccaatttgtg acacggttaa atgataatcc gcggaaagcc aagtacccag aaagctgaac 301261 gatgcgaagt ttccggtttg aaacagaaaa taggcaagca gaatgaccga tgttttcggc 301321 aatgaaaaaa gctcccgata ggggttgaca attgatgggc gcgccaatgg ttcagaaggc 301381 cggatgccag gcatgaccgc cgccaggatc aatagaagaa taagcgagca cgctgacaaa 301441 acgaaaaatg gcgtatgcca tgtaaaggaa gcgagaaacc ctccaatagg aagtccgagc 301501 atttgtgaag cggccaaacc tgctgtcgca atccccatgc cttttatgat ctgagaaggc 301561 tggacaatga ctgggatgga cgcccaaatt tgaggcgtca caaacgcagc gctaacgcct 301621 gcggcaaaac ggaacaggca catggcggca aaagagggag cgatgccgca taaaaatgtg 301681 gatacgataa agcctgcaag tccccacagc atgactgttt tcctgttcag ccggtctgag 301741 attgggcctg caatgaaagc gaagagtgca taaccgagtg cataagcact gaccatccag 301801 cctgacaaat cagtagagac atgaaactga tcctgtaaaa gggggagaag cggcgaaagc 301861 aaaaaggtat ccgtgccaat gacaaacatg acactgaaga aaagccaaat gcgattcaaa 301921 ttttatcact cctattgttt tataacttta aaactatgaa acagatatgt atagagaaaa 301981 ccctttgtta gagggtttcc aaaaagccag gcaggtatgt ttgaaatgtg tcttcacgca 302041 gactgacgta ttttgtccgc gaatctttcc gggttgccgt caatcccgct tcacgcagcg 302101 ttttaaaatg ataagatgcc gtggttttga caatattgca cttttcacct acttcaccgc 302161 agctgagttc ttttccgctg acataaagcg tacgaataat ggcaagcctt gattcatcag 302221 acagtgcttt aaaaatttgc gctctgattt gatcatctga ttgtttcata gtcatgaaac 302281 tataatacat aatgggtgtt gaaaaagcaa cttatttttc cagtaaagga gcaggaagtc 302341 ataagaggaa ggaggaattc aattccaata aaagcgtttt caactaaagg taggagaaaa 302401 atcacccgta aaatacaatc atataggagg attacagagc atttagaagc ataaataaga 302461 tcatgtggtc acatggatgt ttataaagaa atggtacaga ataaaagaga atatgctgtt 302521 tgtgtgggaa gttacataaa tgttacggta ataaagattg cttaatatgg agggaaaata 302581 tgagtgtaga tgagaaacca attaagataa aagtcgagaa agtctctaag atttttggga 302641 aacaaacaaa gaaggcagtt caaatgcttg ccaacggaaa gacaaaaaaa gagatcctga 302701 aagcaaccgg atcaaccgtt ggggttaatc aggcagattt tgaagtatat gatggtgaga 302761 tatttgtcat catgggtcta tcagggagcg gtaaatcaac tttagtacgg atgttaaacc 302821 ggcttattga accgactgcc ggaaatattt acattgatgg tgacatgata acaaatatgt 302881 caaaagacca gctccgggaa gtccgccgga aaaaaatcag catggtcttc caaaagttcg 302941 ctctgtttcc gcacagaacg atacttgaaa acacagaata cggactggag cttcaaggtg 303001 tagacaaaca agagcggcag caaaaagcgc ttgagtctct taagctcgtt ggactggaag 303061 gatttgaaca ccaatatccc gaccagcttt ccggcgggat gcagcagcgt gtcggccttg 303121 cccgcgcgtt gacgaatgac ccggacatcc ttctgatgga cgaagcgttc agtgcgctcg 303181 atccactgat tcgtaaagat atgcaggatg agcttcttga tcttcacgat aatgtcggaa 303241 aaacaattat ctttattacg catgacttgg acgaagcgtt gcggatcggc gacagaattg 303301 tcctaatgaa ggacggcaac atcgttcaaa tcggcacgcc tgaagaaatc ctgatgaatc 303361 catctaacga atatgttgag aaattcgtcg aagatgttga tttgtctaaa gtcctcacag 303421 caggccacat tatgaaacgc gctgaaacag tgcggattga taaagggcct cgcgtagcat 303481 tgacactgat gaaaaacctt ggaatttctt caatttatgc agtggataaa caaaagaaat 303541 tattaggtgt tatctatgcg tctgatgcga aaaaagcggc tgagtctgat ttgtcacttc 303601 aagacatctt gaatacagaa tttacgactg taccagagaa tacgtatctg actgagattt 303661 ttgacgttgt gtccgatgcg aatattccaa ttgcggttgt ggatgagaag caaagaatga 303721 aaggaattgt cgtaagaggc gcgctgattg gcgcacttgc cggcaataac gagtatatca 303781 atgctgaagg cactaacgaa caaacacaag atccttctgc acaggaggtg aaataagatg 303841 gatagactgc ctagaatacc tttagcagat attattgacc gttttgttga ctggattacg 303901 atgacgtttg gcggattctt cgacggaatc gctaacggat tggccgcttt tgtaaatgga 303961 attgtcaccg gtcttggatt tattccatct attttgttaa cgattatttt cgccgcactt 304021 gcgtggtgga tcagtacaag gggaattgcg ttatttacgt tgattggatt cctcctgatc 304081 gattatttag gatattggga cccaatgctg caaacattgg cgcttgtttt gacatctgtg 304141 attatttcga ttgtggtcgg ggttccgatc ggaatttggg cgtctcagaa agaaacggtt 304201 cgccgtattg taacgccaat tcttgattta atgcagacaa tgcctgcttt cgtatatcta 304261 ttgccggcga ttttcttctt taacatcggt gttgtgccgg gtgttgttgc atctgttatc 304321 ttcgcgatgc cgccgacaat ccgcatgact gttctcggta ttaaacaagt gccggcggat 304381 ttgattgaag cgactgaggc attcggttct acaacagctc agcgtttgtt taaagttcag 304441 ctcccgcttg cgacaaaaac gattttggcc gggatcaacc agagcatcat gcttgcgtta 304501 tcaatggttg ttatcgccgc aatggtcggt gcaccgggac ttggttctga agtatacagt 304561 gccgttacac agctgaaaac cggggtcgga gtagaggccg gtatcgccat cgttatcgtt 304621 gccattaccc tggaccgtat tactcaaaat attaaagtga agaagaaaag cagggggaat 304681 gcctgatgct taaaaaaatc ataggcatcg gcgtttccgc catgctggcg ctctcacttg 304741 cggcttgcgg ttcagaaaac gatgaaaatg catccgcagc agaacaagtg aataagacca 304801 tcatcgggat tgaccccggt tcagggatta tgtccctgac tgacaaagcg atgaaggatt 304861 atgacctgaa tgactggaca ttgatttcag cgtcaagtgc tgcgatgacc gctacgctta 304921 aaaagtcata cgaccgtaag aaaccgatta tcattacagg atggacaccg cactggatgt 304981 tctccagata taagctgaaa tatctcgatg atccgaaaca atcttatggc agcgcagagg 305041 aaatccatac gatcacacgc aaaggcttca gcaaagagca gccgaatgcc gcaaagcttc 305101 tgagccagtt taaatggacg caggacgaaa tgggcgaaat catgatcaag gtggaagaag 305161 gcgagaaacc tgccaaagtt gctgctgagt acgtcaataa acacaaggat cagattgccg 305221 aatggacaaa aggcgttcaa aaggtgaagg gagacaaaat caaccttgcc tatgtggcgt 305281 gggacagtga gattgcaagt acaaacgtca taggcaaagt cttagaagac ttgggctatg 305341 aggtaacact tactcaggta gaggctgggc cgatgtggac tgcaattgcg acgggaagtg 305401 cggatgcatc cctttccgca tggctgccga atacccataa agcatacgcc gctaaatata 305461 aaggcaaata tgatgatatt ggcaccagta tgactggtgt gaagatgggg cttgttgttc 305521 ctcaatatat gaaaaatgtc aactcaattg aagatttgaa gaagtaatca aaaaagcagc 305581 ctgtgtcagg ctgctttttt tgcgttaaga agcgttagcg gcagcaagtg attccgcctt 305641 ctgaaatgtt ttgagcacgg cgttcgccaa aatatgaatg ccggtaaaca tcgcatttct 305701 gtcaaaggtc atgtgcggat gatggagccc cggctggagc ccgcagccta gtccgagcat 305761 cgttgttttc agattcggca ccttcacggc gtaaaaatgg aaatcctcgc cgccggtggt 305821 gacaagcggg tcatcaagcc gctcagcccc gatgatttcc gtaatggctt ctgccatgat 305881 cgcttcagct tctttatttt gtgttgccgc aggaaggctg tgttctttgt gcagctcgat 305941 ctttgcgcca aatgcagcgg cggccgcttc acaggctctt tctgtttcgg cgattaatgc 306001 ctccatggct tcattggtct gtgcgcgcaa atcaaggctg aacgatgctt ttcctggaat 306061 gatgttagag ctttcaccgc cggcttgcag ttttgtcatt ttgacggtat gcgggatttg 306121 cgggtcaata tgaatgagtc cgagcttgtg tacaagaaat gccgcaattt caatgctgtt 306181 tttcccgagg tgcggacggg cgccatgagc ctcttccccg atgatcgttc cctcaatgtg 306241 ctggcttgat ccgtgcagaa tagaaggagc gcagcggccg ttctgtgttt cctggatcgg 306301 acggacgtga acgccataca aatagtcgat atcatcaagc acgccttctt ctatcatttt 306361 caaggcgccg ccgccttttt cttctgccgg ctgaaagata aaacggattg tgcccttcgg 306421 aagctcaggt tgttttttta gcagcattaa cgtgcccaat gccattgtca tatgtgaatc 306481 gtgtccgcag gaatggttgg cgcgaaatgt gccgttaacc tcctgccaca gcgcgtcaat 306541 atcagcgcgt accgctacaa caggtgagcc tgagccgatt tcgccgacaa ccccggtgca 306601 gtctgaaaac gtgcgcgtcc ggcaccctaa atcctcaagc ttttgtttca aaaatgaagt 306661 tgtctcatat tccttccagc tgacttcagg gttcgcgtgc agatgctcga agatgtccat 306721 aatggtttgt ttcatttctt ctgaaagctt ttgcatggta agaaatacct ccttctatca 306781 gaatgaattt ttaccttctt tactttattt atattgaaac aggaagatag gctgtatata 306841 atatagcaca tattgctact attcagaata attaatattt tcaaacagag gggatggatc 306901 gaaatatgag tatgccagca gccgaaacac agcctaagaa aaaacgtatg acatttaaaa 306961 tgcctgacgc ctatgtcctc ttatttatga ttgctttcat ttgcgcaatc gcttcatata 307021 ttgtgccggc aggtgaattt gaccgcgtga caaaggggga tgtcacgacc gctgttccgg 307081 gaagctatca ttcaattgaa cagtctccgg tcagattgat cagctttttt acttctctac 307141 aggatggaat ggttggatca gcacccatca tctttctgat tttattcaca ggcggcacca 307201 ttgctattct agaaaaaacg ggtgccatca atggcctgat ttacaatgtc atcagcaaat 307261 tccgcacaaa gcaattatta tttatttgta ttgtcggcgc attgttctcc attctcggaa 307321 caaccgggat tgtcgtgaat tcagttatcg gttttatccc catcggcctc attgtggcac 307381 gatccttaaa atgggacgca gtcgcgggag ccgctgttat atacatcggc tgctacgctg 307441 gatttaactc caccatatta tcaccgtcac cgctcggttt atcacaatca atcgcggagc 307501 tccctctttt ctcaggaatc ggcctgcgag ttgtgatata catatgcttt ttgctgtctt 307561 ctattattta tatctatttg tatacgagaa aattaaaaaa atcaaaagat gccagtgtgt 307621 taggaacaga ttggttccct gcggcaggaa tgggcgaagc cggtaaagaa gaagatcagt 307681 cagtgccgtt taccgttcgc cataagctga ttttggctgt ggcgggactc tcacttgtcg 307741 gatttttata cggcgctttg aagcttggct ggtcagattc ccaaatggct gcgacattta 307801 tttttatttc tgtccttgcc ggtttaatag gcgggcttgc ggcgaacgat attgccaaaa 307861 ccttcattac gggctgccaa agtcttgtat acggggcgct gattgtcggg atggcacgaa 307921 gcatttccgt tatccttgaa aatggaaagc ttctcgatac tgtcgtcaat gctttggctt 307981 cacttttgga tggattcagc ccgattgctg gggcaatcgg catgtatatc gccagtgcgc 308041 tgcttcattt tctcatctct tcaggttctg gcgaagccgt tgtatttatt ccaatcctgg 308101 cgccgctcgc tgatttgatg ggaatcacga gacaggttgc ggttgaagcg gttatgcttg 308161 gagaaggggt cgtcaactgt gtgaacccga catccggcgt tctcatggcg gtgcttgccg 308221 ccagcggtat tccgtatgtc aagtggctgc ggtttatggt gccgcttgct ctgatttggt 308281 tcttgatcgg gcttgtcttt atcgtgatcg gagtcatgat caattggggg ccgttttaac 308341 gattgctgcc cgccggcttg tacggcgggc ttttgagtta ttcattgcag aagcgcaggc 308401 tgttattgta acatgtaagc cataagccat tcgtaaaagt gcgggaggaa ggtcatgaat 308461 aatctgcgta atagactttc aggcgtgaat gggaaaaata agagagtaaa agaaaaagaa 308521 caaaaaatct ggtcggagat tgggatgata gcgggagcat ttgcgctgct tgatgtgatc 308581 atccgcggca ttatgtttga atttccgttt aaagaatggg ctgcaagcct tgtgtttttg 308641 ttcatcatta tcttatatta ctgcatcagg gctgcggcat ccggaatgct catgccgaga 308701 atagacacca aagaagaact gcaaaaacgg gtgaagcagc agcgaataga atcaattgcg 308761 gtcgcctttg cggtagtggt gcttacgatg tacgacaggg ggattcccca tacattcttc 308821 gcttggctga aaatgattct tctttttatc gtctgcggcg gcgttctgtt tctgcttcgg 308881 tatgtgattg tgaagctggc ttacagaaga gcggtaaaag aagaaataaa aaagaaatca 308941 tcttttttgt ttggaaagcg agggaagcgt tcacagtttc gggcagcttt ttttatagga 309001 acattgattt gtattcactc tgccaagttg ttttgataga gtgattgtga taattttaaa 309061 tgtaagcgtt aacaaaattc tccagtcttc acatcggttt gaaaggagga agcggaagaa 309121 tgaagtaaga gggatttttg actccgaagt aagtcttcaa aaaatcaaat aaggagtgtc 309181 aagaatgttt gcaaaacgat tcaaaacctc tttactgccg ttattcgctg gatttttatt 309241 gctgtttcat ttggttctgg caggaccggc ggctgcgagt gctgaaacgg cgaacaaatc 309301 gaatgagctt acagcaccgt cgatcaaaag cggaaccatt cttcatgcat ggaattggtc 309361 gttcaatacg ttaaaacaca atatgaagga tattcatgat gcaggatata cagccattca 309421 gacatctccg attaaccaag taaaggaagg gaatcaagga gataaaagca tgtcgaactg 309481 gtactggctg tatcagccga catcgtatca aattggcaac cgttacttag gtactgaaca 309541 agaatttaaa gaaatgtgtg cagccgctga agaatatggc ataaaggtca ttgttgacgc 309601 ggtcatcaat cataccacca gtgattatgc cgcgatttcc aatgaggtta agagtattcc 309661 aaactggaca catggaaaca cacaaattaa aaactggtct gatcgatggg atgtcacgca 309721 gaattcattg ctcgggctgt atgactggaa tacacaaaat acacaagtac agtcctatct 309781 gaaacggttc ttagacaggg cattgaatga cggggcagac ggttttcgat ttgatgccgc 309841 caaacatata gagcttccag atgatggcag ttacggcagt caattttggc cgaatatcac 309901 aaatacatct gcagagttcc aatacggaga aatcctgcag gatagtgcct ccagagatgc 309961 tgcatatgcg aattatatgg atgtgacagc gtctaactat gggcattcca taaggtccgc 310021 tttaaagaat cgtaatctgg gcgtgtcgaa tatctcccac tatgcatctg atgtgtctgc 310081 ggacaagcta gtgacatggg tagagtcgca tgatacgtat gccaatgatg atgaagagtc 310141 gacatggatg agcgatgatg atatccgttt aggctgggcg gtgatagctt ctcgttcagg 310201 cagtacgcct cttttctttt ccagacctga gggaggcgga aatggtgtga ggttcccggg 310261 gaaaagccaa ataggcgatc gcgggagtgc tttatttgaa gatcaggcta tcactgcggt 310321 caatagattt cacaatgtga tggctggaca gcctgaggaa ctctcgaacc cgaatggaaa 310381 caaccagata tttatgaatc agcgcggctc acatggcgtt gtgctggcaa atgcaggttc 310441 atcctctgtc tctatcaata cggcaacaaa attgcctgat ggcaggtatg acaataaagc 310501 tggagcgggt tcatttcaag tgaacgatgg taaactgaca ggcacgatca atgccaggtc 310561 tgtagctgtg ctttatcctg atgatattgc aaaagcgcct catgttttcc ttgagaatta 310621 caaaacaggt gtaacacatt ctttcaatga tcaactgacg attaccttgc gtgcagatgc 310681 gaatacaaca aaagccgttt atcaaatcaa taatggacca gagacggcgt ttaaggatgg 310741 agatcaattc acaatcggaa aaggagatcc atttggcaaa acatacacca tcatgttaaa 310801 aggaacgaac agtgatggtg taacgaggac cgagaaatac agttttgtta aaagagatcc 310861 agcgtcggcc aaaaccatcg gctatcaaaa tccgaatcat tggagccagg taaatgctta 310921 tatctataaa catgatggga gccgagtaat tgaattgacc ggatcttggc ctggaaaacc 310981 aatgactaaa aatgcagacg gaatttacac gctgacgctg cctgcggaca cggatacaac 311041 caacgcaaaa gtgattttta ataatggcag cgcccaagtg cccggtcaga atcagcctgg 311101 ctttgattac gtgctaaatg gtttatataa tgactcgggc ttaagcggtt ctcttcccca 311161 ttgagggcaa ggctagacgg gacttaccga aagaaaccat caatgatggt ttcttttttg 311221 ttcataaatc agacaaaact tttctcttgc aaaagtttgt gaagtgttgc acaatataaa 311281 tgtgaaatac ttcacaaaca aaaagacatc aaagagaaac ataccctgga aggatgatta 311341 atgatgaaca aacatgtaaa taaagtagct ttaatcggag cgggttttgt tggaagcagt 311401 tatgcatttg cgttaattaa ccaaggaatc acagatgagc ttgtggtcat tgatgtaaat 311461 aaagaaaaag caatgggcga tgtgatggat ttaaaccacg gaaaggcgtt tgcgccacaa 311521 ccggtcaaaa catcttacgg aacatatgaa gactgcaagg atgctgatat tgtctgcatt 311581 tgcgccggag caaaccaaaa acctggtgag acacgccttg aattagtaga aaagaacttg 311641 aagattttca aaggcatcgt tagtgaagtc atggcgagcg gatttgacgg cattttctta 311701 gtcgcgacaa atccggttga tatcctgact tacgcaacat ggaaattcag cggcctgcca 311761 aaagagcggg tgattggaag cggcacaaca cttgattctg cgagattccg tttcatgctg 311821 agcgaatact ttggcgcagc gcctcaaaac gtacacgcgc atattatcgg agagcacggc 311881 gacacagagc ttcctgtttg gagccacgcg aatgtcggcg gtgtgccggt cagtgaactc 311941 gttgagaaaa acgatgcgta caaacaagag gagctggacc aaattgtaga tgatgtgaaa 312001 aacgcagctt accatatcat tgagaaaaaa ggcgcgactt attatggggt tgcgatgagt 312061 cttgctcgca ttacaaaagc cattcttcat aatgaaaaca gcatattaac tgtcagcaca 312121 tatttggacg ggcaatacgg tgcagatgac gtgtacatcg gtgtgccggc tgtcgtgaat 312181 cgcggaggga tcgcaggtat cactgagctg aacttaaatg agaaagaaaa agaacagttc 312241 cttcacagcg ccggcgtcct taaaaacatt ttaaaacctc attttgcaga acaaaaagtc 312301 aactaaccgc aactttagag taaagggctg attgtcaatg tgggagcagt tgtatgatcc 312361 gtttggaaac gagtatgtga gcgcacttgt ggcgctcact ccgattctct tttttctttt 312421 ggctttaact gttttgaaaa tgaaaggcat tcttgcggca tttcttaccc tagccgtcag 312481 tttcttcgtc tccgtttggg catttcatat gccggttgaa aaagcgattt cttctgtttt 312541 gttaggaatc gggagcgggc tgtggcccat tggctacatc gtcctgatgg cggtgtggct 312601 gtataaaatc gccgtgaaaa ccgggaaatt taccattatt cggtccagca ttgccggcat 312661 ttcgcctgac caacgattac agctattatt aattggtttt tgttttaacg cgtttttaga 312721 aggcgcggcc ggttttggtg ttccgattgc gattagtgcg gcgctgctcg tcgaacttgg 312781 ttttaaaccg ttaaaagcgg cggcgctctg cttgattgca aacgctgcct ccggagcctt 312841 tggggcgatt gggattcctg tcatcacagg ggcgcagatt ggtgatttgt ctgctcttga 312901 gctgtctcgg acattaatgt ggacactgcc gatgatctca tttttaatac cattcctgct 312961 tgtattctta ttagaccgaa tgaaaggaat caaacagaca tggcccgctc ttctggttgt 313021 gagcggtggg tatacagcgg ttcagacact gacaatggcg gtgctcgggc cggaattagc 313081 aaacattttg gcggccttat tcagcatggg cgggcttgcc ctcttcctcc gcaaatggca 313141 gccgaaagag atttaccgcg aggaaggggc cggcgatgct ggtgagaaaa aggcataccg 313201 tgccgctgac attgcgaaag cgtggtctcc tttctacatt ttaactgcgg cgatcaccat 313261 ctggagcctt cctgccttca aagcgctttt ccaagaaggc gggctgttat atcaatcaac 313321 gctcctgttc aaaatgcctt ttctgcatca gcaaattatg aaaatgccgc cgattgcgcc 313381 atctgccatg ccgttagatg cagtctttaa agttgatctg ctgtcagcga ctggtacagc 313441 gattttagcg gcggtcatcg tgacagggct gttcagcaaa aagttctcct ctcgggatgc 313501 ctttgcttcc ttgaaggaga cgggaaaaga gctgtgggtg ccgattatga cgatctgctt 313561 cgtgatgggg tttgccaatc tggccaactt cgcagggctc agctcttcaa ttgggttagc 313621 attggcgaaa acaggagacc tgttcccgtt tgtcagtcct gttctcggct ggattggcgt 313681 gttcatcacc ggttctgttg tcagcaataa tgctttgttc ggccatttgc aggttgtcac 313741 gggagcgcag atcggtgcgg gttcagattt gctgttagcc gcaaatacgg cgggcggtgt 313801 catggcgaaa cttgtttctc ctcaatctat cgccatcgct gccgcagcgg tcggccaaac 313861 aggcaaggaa tctaaactgt ttaaaaggac agtggcgtac agcctgattc tgttattgat 313921 catttgtata tggacgttta ttcttgcaag attaggagtg taatagaaaa aagcagtaca 313981 tgcccagcat gtactgcttt ttttatgtta atttgctttc tttgtcattt cggctgttgt 314041 tttcactctg gcttttccca taaataaaat ggtaaccgcc gcgaggacaa ttggaatcaa 314101 agcgagcaaa aagacatacg tgatacttga tgacatcgcg tcaataatgc gattcaggat 314161 cgcatcagga atctgggaac gtgttcccgc ttggaatatc tcctgcgggt cgccaatatt 314221 ttgcgcagcg cctgatcccg ctgagccttt cataccgctg aaggcgtcat tcagcttgtt 314281 tgtgaatacg tttgtttgca ccgttccgaa aatggtgaca cctaaggtca tgccaaatga 314341 tcgcaaaaat gaatttgtag agtttgccgt tccccgaaag cgaggttcaa gatcattcat 314401 cgatgccgcc ggcagcaggg agaagttaaa gcctacacca aagcctgaaa tcatcataaa 314461 gactgtcagc catacccgtg ctgtgtcagg cgtcatattg gaaagaagca gcatgccgat 314521 aaagaaagct ataacagata tcagcatcaa attgcggaag cttgccttcg tttggaagat 314581 cccgccgatc atgcttccga tgactgatcc aatcatcatc ggcgtcagaa tgaagcccgc 314641 gcttgtcgcc gagctgccgt agaccgcctg aacgaaaatc ggaataaata ccgctaaaat 314701 aataaatgtt ccgccataca ggaaagcgag aatctgtgct gtggcaaaca agcggttctt 314761 aaacatccag aaagaaataa tcggctcttc tgcttttctc tccacaataa aaaaggcaat 314821 gaagaaaacg gcgaatacaa taaacagccc gatgatctga atggagttcc aatcgtatgt 314881 tttgccgcca agctcaaggg cgaacatcag gcatacaatg gatacgacta aggtaatcgc 314941 gccgccccag tctattttct gctttctgtg ctccagagat tctttgtagt agcgaataat 315001 gaaaaacaat gacaatgcgc cgatcggcac attgatgtaa aacacccagt gccagctgat 315061 cgaatctgta atgatcgcgc ctaagagcgg accaagaaca ctggataatc caaatacagc 315121 accgaacatg ccggacattt ttccgcgttt ttccggcgga aacaaatcaa agataatggt 315181 aaaggcaatc ggcaggagcg cgccgcctcc gatcccttga atggcccgga agatgatcag 315241 ctgattcatc gtctgggcaa tcccgcataa agcagaaccg attaagaaaa aaataagtcc 315301 aaacaggaaa aaacgttttc ggccgtacat atcggaaagc ttgccgtaaa tcggcatgcc 315361 agccataacc gccaccatat aggatgccgt cacccaggca aatttatcga agcttccaag 315421 atcggctacg atattgccca tcgcggtggc aacaatcgta ttgtccattg cagacatcaa 315481 gatgcccagc aggagaccga ggaccacaaa tttggtggaa gcctgttttg ctgttgttgt 315541 gtccatttgt tctacctcct cttacttttc tatgtaagtt ctgatatcat gataatagtt 315601 tgattgttga atatctcgat tatcaagata aactcgattt tatagggagg actgtcagtt 315661 gtcaacaaga aattccagaa gtgagttgga aaagactgct gttcagcttt ttcgaaaact 315721 gggcacaaga acggttctgt ttcatcaggc agccgctcaa gctctcggtc tgtttcccac 315781 cgatttgaaa tcagctgaca ttttaaatga agcagggccg atgacggccg gagagctggg 315841 gaaaaaaacc ggcctcagca cgggttccgt cacggcgctt gttgaccggc tggaaaaagc 315901 ggggtatgtg gctcgtgaaa aggacccgaa cgatcgcagg agagtcgtaa tcgtcccttt 315961 gactgcttcg aaaaaacata taaaggattt gttccgtcct ctgtctgagt caacgatgga 316021 tttgtgccgc gaatatacgg aagaggagct ggaactcatt ttcagttttg taggcaaagc 316081 tgccgatatt atggaggaag agcttgaacg tctgaaacag taagtgaatt tgtgcatagc 316141 ttggcccgtt cccgaataaa ttgtacaagt tacataagag aagggagtac gggccggtga 316201 acattttttt gagctatatt gtgctgggac tgtccttgtc tgcgcctgtg gggccagtga 316261 atgcggcgca aatagacaaa ggaattaaaa acggtttttg gcatgcatgg attttcggtt 316321 taggcgccat gacagcggat gggctgtaca tgctttttat ctatttcggg ctgtcgcagt 316381 tcttgaccgc tccatttgtg aaaacgtttt tgtggctgtt cggctttttt gtcctgacct 316441 ataccggaat tgaaacgctg aaaaacgtca gagaaccgat ggatgtgcga agctcgcggg 316501 ggaaaccgtc atacaggaaa acattcgcat cgggttttct catttcattg tcaaacccat 316561 tgagcatcct tttttggctt ggaatttacg gaagcattct tgcgaaaaca gcagaggcct 316621 acaatatgaa tcagcttcta atctatagct ccggcatcat gatcggcatt ttaatctggg 316681 atttctgcat ggctatcaca gccagtacgt tcagaaacct gcttcatgaa aagctattga 316741 gaggattgac cggaatcgcc ggtgtatccc tccttgtgtt tggcttttac tttggttatc 316801 agggcatcaa acagttattg ggctgattca tgaaggacag tcacctgccg cttccagttt 316861 taatatagta tccagatgat actggaggtg gatcaatggt gaatgggatt tacaccaaaa 316921 gttttctgga acgtattcag gaagagcttc ctgaatggca aagaatcgct tttgagctgc 316981 tggcagaaac tctgggggac gacgcggata catttccgtg cattcccgga cgccaggcgt 317041 ttctgactga tcagcttcgg attgcttttg ccggagatcc gcgggaaaac cgcacagcgg 317101 aggaactggc tccgttgctt gcggagtacg gcaagatatc gcgggacacg ggaaaatacg 317161 catccctcgt tgtgttgttt gatacaccgg aagatttggc ggagcattat tcgattgaag 317221 cgtatgaaga gctgttttgg cgctttttaa atagactgag tcatcaagac gaaaaagaat 317281 ggccggaaga cattccggcc gatcctgagc attataaatg ggagttttgt tttgacggcg 317341 agccgtattt cattctgtgc gctacaccgg ggcacgaggc aagaagaagc cggagctttc 317401 ctttttttat ggtcacgttt cagccaaggt gggtgtttga tgacctaaat ggatcaactg 317461 catttggccg taacatgagc aggctgatcc gatctcgttt agaggcctat gatcaggctc 317521 cgattcaccc gcaattaggc tggtacggag gaaaagataa tcgtgaatgg aagcagtatt 317581 tcctccgtga tgacgaaaaa caggtatcga agtgcccgtt ttcttattta aagaacatgt 317641 tcaacaaaat gaaataaatc aaggactggc agggcgatct ttatgaccct gctttttttg 317701 atagatcatg gtaacgatgg cgataatcac gagaaaacct atgctgacga aaaaaccggg 317761 ccggcttgat ttttcaaaca atgtaccgga cacagctgca gcaatcagaa ccatcgctaa 317821 ataaatttgc gtttttccca tgccctcggg atcagtcagc tttttgctgg agaacaggat 317881 aaacagccaa gtgtataaaa gcataagccc cgcagctgtt gtcatatgct cataaatgtt 317941 tttaggcagc actaacgaca aaataatgga gaggacaagc cccgcaaacg tcagcccaag 318001 tgccggccag catatttttt tgccttcctt tagagtaaag catttcggcg cgtcgccgtc 318061 atcagccatt gtacaaagca atgtcgtaac cgcaaatagc gaagcgacaa gggtcgagaa 318121 ccctgcgatg atgaaaatcc cgttaaatat atcaaggatg atctcaaggt tatatccttt 318181 taatgacgta atgaacggac tgtcctgttc agtaaacgtg tgtaacggaa ccaaaagcag 318241 agcaagcccg attgaaatga tataaataat cgccagcgtc gccagcatca gtttccctga 318301 tttagacgct tcctcaggtt tttttaagtg aaccgccatc agccccatga cctcaattcc 318361 gccaaaagcg taaaacgcgt agattaaacc tgtccacagc cccatggcgc cgtatgggaa 318421 aaactcactc gtcttatttg gaacatgtat gccatgattt ccgccggaca ggataccgca 318481 taaagccagg atggcaatga caataaacat aaaaatagca gctgttttaa tgactgccag 318541 cacgttttct gttttttcaa agacggacag gccggtgaaa ataataagga gcccaagtac 318601 tgcgtagatt gaggcaaaca cccatagcgg cacttgagga aaccaatgct tcgtaaagag 318661 cgaaatggct gtcagctggc ttccggtaat cagcatttct gatgtccagt acacccagcc 318721 gttgctgaag cctgcccatt tgccgaatgc ttttcgggca tacgcacaaa acgagccctt 318781 ttccggctgc ttcgccgata gcttggcgag ctgttcaaag acaaaatacg taccgatccc 318841 tgcgatcaga aatgaaagga gaacggaaaa accgcttttt acaattgcga tgctggaacc 318901 gagaaagaag cctgttccaa tcgtgcagcc gactccgatc agtgacagct gccaccaagc 318961 cagattccct tttggctggt ctttttttgt ttggctcatt atttattcaa ccccttttat 319021 ctaaggttag attgtgatct gtccaaagct tatatacatc ggatttttgc ctctttttac 319081 atggagaagg aagcagacgc tcatactaat gaaaaaagga gcaaaccaat gacacagcaa 319141 tatattgtgg agccgaaaaa agggcttggg ctgaagctga aaaaggggca gattttaaag 319201 gtggttgatg tagaagggca gcaggtggct gattttgtcg cataccatgc caaggatttt 319261 tatgaacacc ttgatcaggg agcgacgata gacgccaatc actccattca tgtgaaggtc 319321 aacgaccatc tctactccaa cctgtataag ccgatgttaa ccctgattga agatacggtc 319381 ggcaagcatg atctgctgtt gcccgcctgc cgtcctgata tgaacaggct cttatatggg 319441 aagcaaaagg atgagtttca ggatacgtgc tatgacaata tgaaccgtgc gcttgagcag 319501 tttggcgtac cgaagcccca catgcattac ccatttgcga tttttatgaa tactgtcctt 319561 gatgagaaag ggaatctgtc tgtggaaacg ccgctttcga atgccggaga ttatgtaagg 319621 ctcagggcgg agatggattt aattgtcgcg ttttcttcct gcccgattga aaaagggaaa 319681 tgcaatggcg acagtgtgac atccatacgg gttgaagtca gctgatctct cttgttcaca 319741 gtgaatgaag acctgtgcta tatttaatag ggatacataa cagtcatgat tcattttcat 319801 tgatttaggg aaatgatcag taataaggga aaatgtacag gaggaatgat tgggatgagc 319861 atgcaggaaa agattatgcg tgagttacat gtgaagccct caattgatcc aaagcaagaa 319921 attgaggacc gagtcaattt tttaaaacaa tatgtaaaga aaaccggtgc taaaggcttt 319981 gtattgggaa tcagcggggg ccaggattca acacttgcgg gaagactcgc tcagcttgcg 320041 gtggagagca ttcgcgagga gggcggagac gctcaattta tcgcggtccg tcttccgcat 320101 ggcacacagc aggatgaaga cgatgcccag cttgctttga agtttattaa gccggataaa 320161 tcatggaagt ttgatattaa atcgacagtc agcgcttttt ctgatcagta tcagcaggaa 320221 acaggcgatc agctgacgga ctttaataaa ggaaacgtaa aagcaagaac aagaatgatc 320281 gcgcaatacg cgatcggcgg ccaggaaggt cttcttgtgt taggaacaga ccatgctgct 320341 gaagcagtga ctggtttctt tacgaagtac ggtgacggcg gagcagacct cctgccgctg 320401 acaggcttga cgaagcgcca gggaagaacc ttgctgaaag agctgggtgc accggaacgc 320461 ttatacttaa aagaaccgac tgccgatctg ctcgacgaaa aaccgcagca gtcggatgaa 320521 acagagcttg gcatttccta cgacgagatt gacgattatc tcgaaggaaa agaagtatca 320581 gcgaaagtat cagaagcgct ggaaaaacgc tacagcatga ctgaacataa acgccaggtt 320641 ccggcgtcta tgtttgatga ctggtggaaa taagttgaag aaagcccgct ctcggagcgg 320701 gcttttgtcg tgtacagaag ctttatttga tgcggatatg attcagcttt accattaatc 320761 tgtcggcgaa ccttcggagg ctgcctcttg tatcaggatc taatgggagt tcggctctcg 320821 cggcaatgtt ctctgccaca tcctgaatcg acaggttgtc tgtttgaatg tggtcctcaa 320881 aaatgggtga tgataatcct tcaacacagc ggtcaatttg tttggcggcc catgagtttt 320941 ttccttctgc tctggtgcgc agccttttta acaaggtttc ctttgaagcc attagtgtaa 321001 agtggtgaac gatcctgcct tcctgtctga gcctgccgat gatctcattg aagtattcag 321061 ggtgtacaat cgtcataggc acaataagga tgccgcggta tgtatctgtc agagaagcta 321121 gcaaactgta attgaacgcc cgccataaag gatagctttg aaaatcgtcc tttgcgatct 321181 cctgcggcac catggagcgc agcgcaaaac ccattttctc gggatcatac acgtaagatg 321241 ggttcagcct tctgtgcagt tcgaaggctg tttgtgtttt tcccgaaccg aatgccccgt 321301 ttatccaaat gatcatcgcc atttctccct tcctatttat catacagaaa aagacccttc 321361 catcgaagag tcagctggaa aaacaataaa ggcggaaggt tttaacgctt ttttgcgtcg 321421 aagtattaaa atacctgcag aaatgttgta caatgaatgt cattcaggca aaaatggcta 321481 caacaaagcg cactataagc ttgaccggta aagccggtat ctatataaat attcgctaaa 321541 taagcatata atgaatatat aatttcattc cttaggagga tttcgccgaa gatgaacgct 321601 aaacgagcca tcccagtaag agaaagaaat atcgtcctga tcggattcat gggtgtagga 321661 aaaacaacaa tcggccaatt ggtcgctaaa aaattatata gagattttat tgatattgac 321721 cagcagatcg aaaaggattt caatatgtca attcctgaga tatttgagaa aaagggagaa 321781 gactttttcc ggaaaacgga gaaggaatat attttagaca tctgccatca taaacgattc 321841 aaaatcgtat ctctgggcgg gggatctttt aaacaagaag aaatcagaaa ttgctgtctg 321901 gaaaactgtc tcgtgcttca tctggacctg tcatgggaga actggaagca gcgcgcggat 321961 ttattgatcg aaagccgccc tgtactgcat aaccgttcaa tggatgaaat ggaacagctg 322021 tttaacgaaa gaaaagtcat ttatgacaag cacaattcaa aagtggcaac agacaacctt 322081 tccccggaag aggttgccga ttacattgtt gagacattaa aaattggctg ggatctttat 322141 cagccgatgt aaaaagccgt gcgcagcgca cggctttttt tatcgtttta tcccttgtat 322201 caaaatcgct tttaaacaaa aggagatggg ctgtccgttt tggttcaatg taatacagaa 322261 cgtgtcgcgt gcttcgtctg atgcgtgatt caagtgggta atgatttgtt tttctcggtc 322321 agcgggggtt ccgcctcgtt tgatccagct atcgtattga atcggcaagt tccacttttg 322381 gatgtcttga taggccagtt gattggcgct gaacatcgcc tgccattctg ataatgagct 322441 ttcacgaaca tgggaagggt ctcgaagccg gttcaaatga ttgacaaact catcaagaac 322501 gggatcttca ggcgcgtaat gatcaactaa gagaaaacgt ccgtcctgtt ttagtacgcg 322561 tgcaacctct ctgacagctt tgcggacatc tgaaaaatgg tgggctgcgt atcggcaggt 322621 gatgatgtca aatgaatcgt cggggaaggg gagtgactct gccgttcctt gctgaaagcg 322681 tacgttttca actccttttt cttgcgcgaa ggaggacgca acctcaacca tctctttcgt 322741 tgcatcaaca ccgatgcact cctgtacata aggagaaaat gccagcgccg tatggccggc 322801 gcccgctcct atatccagca ctcgatgctc tgcccggcat tccgctgttt tgatcatcaa 322861 ccccaaatct tccccctcgg caaatacctt ttcatcccga tacatctcgg cgtttttaga 322921 aaacggtgtt tcatttgtca tttgaaccag ctccttcttt tcgtaaatga tgatatggat 322981 tatgttagca atttctgtta tgattcgtcc aagatataaa aatgatgaaa atgataggtt 323041 caacctatgg aggctgaaat ggatattaaa gtgatggaat atgcagcgga aattgcccgg 323101 cgccaaagct ttacaaaggc ggcggaacat cttcatatcg cacagccgtc tctcagccag 323161 caaatcaaaa agcttgaggc tgagctgggg cttacccttt ttcacagatc ccatggctct 323221 gttacactga cacctcacgg caggcgtttc attgaaaaag ccgaggacat cattcgttcc 323281 agagatgatt tgcttcggga aatgcaggag cgatcacagg gaatcggtca taaattatcc 323341 atcgggattc ctgctgtaac agggagatat ctctttcctc cgctgctgaa gcagtttttg 323401 gcgcgctatc ctcatgtgga ggttcagctt gttgaaaaag atccggtttc attagagaag 323461 atgacggcaa agggagaagt tgacctttct gttttatcct tgcccatcga ggatgaacgg 323521 ctctccatta cacccttgct cacggaaccg gttgttctcg cggtgccgaa ggaaaaacaa 323581 aggtggatgc cgccggaatt ggtcgcgctg attgagaaag cgctggaaga agatgaggga 323641 cgccagccgt gtgtgccgat tgacatggta aggaacgtgc cctttattct gttaaaagaa 323701 ggcttcggct ttcgcaggac agttctcgat ctctgtgcgg aaagcggctt taagccgaat 323761 gctgccttta agacgagcca tattgaaacc gcccaatctc ttgtggctaa cggattaggt 323821 gtgacaatgg caccgaatat ggtcagaagg gataaagatc cgggtgtgat ctatttatcg 323881 attcaatccg cgccatcacg aaccctcgtc tttgtctttt taaagaaccg ctatgtcagt 323941 ctgacggccc aggcctttat ggaactaagc cgggaaagtc ttaaacaaac gtttgatgaa 324001 ggctgtctgg gaaacaaaga tgaaaatatt tagaaaacaa agacgaaacg tggtagtata 324061 ggaatacaaa ctaaatctta taaaacaaag gggaataatc ggaaatgcaa ctattcgatc 324121 tgccgctcga ccaattgcaa acatataagc ctgaaaaaac agcaccgaaa gatttttctg 324181 agttttggaa attgtctttg gaggaacttg caaaagtcca agcagaacct gatttacagc 324241 cggttgacta tcctgctgac ggagtaaaag tgtaccgtct cacatataaa agcttcggaa 324301 acgcccgcat taccggatgg tacgcggtgc ctgacaagga aggcccgcat ccggcgatcg 324361 tgaaatatca tggctacaat gcaagctatg atggtgagat tcatgaaatg gtaaactggg 324421 cactccatgg ctacgccaca ttcggcatgc ttgtccgcgg ccagcagagc agcgaggata 324481 cgagtatttc accgcacggt cacgctttgg gctggatgac gaaaggaatt cttgataaag 324541 atacatacta ttaccgcggt gtttatttgg acgccgtccg cgcgcttgag gtcatcagca 324601 gcttcgacga ggttgacgaa acaaggatcg gtgtgacagg aggaagccaa ggcggaggtt 324661 taaccattgc cgcagcagcg ctgtcagaca ttccaaaagc cgcggttgcc gattatcctt 324721 atttaagcaa cttcgaacgg gccattgatg tggcgcttga acagccgtac cttgaaatca 324781 attccttctt cagaagaaat ggcagcccgg aaacagaagt gcaggcgatg aagacacttt 324841 catatttcga tattatgaat ctcgctgacc gagtgaaggt gcctgtcctg atgtcaatcg 324901 gcctgattga caaggtcacg ccgccgtcca ccgtgtttgc cgcctacaat catttggaaa 324961 caaagaaaga gctgaaggtg taccgctact tcggacatga gtatatccct gcttttcaaa 325021 ctgaaaaact tgctttcttt aagcagcatc ttaaaggctg ataaatgtga aaagccgccg 325081 catatcatca ggcggttttt ttctgcaaac tgccggaatg agaacagact ggagacgaat 325141 agatatgaaa caaagaatca ttgatgaatt aaaacggatc gagcagtcat acggagtcaa 325201 aatcgtgtat gccgtcgagt caggaagccg cgcatgggga tttccctcgc aggatagtga 325261 ttacgacgtc cgctttattt atgttccgaa aaaggagtgg tacttttcaa ttgagcagga 325321 gcgtgatgtc attgaggaac cgattcacga tttgctggat atcagcggct gggagctgag 325381 aaaaacgctt cggcttttca aaaagtcaaa ccctccgcta ctcgaatggc tgtcctcaga 325441 cattgtgtat tatgaagcat ttacgaccgc agagcagtta agaaaactcc gcacggaggc 325501 atttaagcct gaagcaagcg tgtatcacta tatcaatatg gcgagaagga acgtcaagga 325561 ttatctacaa ggacaagagg tcaaaattaa aaagtacttc tacgttcttc ggcctatttt 325621 ggcctgccaa tggattgaaa agcacggaac cataccgcca atggacttta ctgttttgat 325681 gaatgaactt gttgctgaac ccgagctgaa ggctgaaatg gaaaccttgc ttgaacggaa 325741 aagaagaggg gaagagcttg acctcgaagc aagaatcgat gttattcacc aattcattga 325801 aacggaaatc gaaagaatca tggaagcggc aaaagaactg aaggcagaga aaaaagatat 325861 gacatctgaa ttgaaccgtt tgcttttgaa tacggttgaa gaagtgtgga aggatggagg 325921 aagctgatgt tttttgtcgc ttccttttct cctttattcg acagaatccc cccccgactt 325981 tctaactatc tgattgtggc aaacccacaa aaataatcag aatctttgta ttttgagaat 326041 attgtgaacg ctggttttgt ccatttacaa taaactcata caaatacttc ttagattgcg 326101 gggtgttgag gttggaagtg atcacaagag attttttctt atttttatcc aaaagcggct 326161 ttctcaataa aatggcgagg aactggggaa gtcgggtagc agcgggtaaa attatcggcg 326221 ggaatgactt taacagttca atcccgacca ttcgacagct taacagccaa ggcttgtcag 326281 ttactgtcga tcatttaggc gagtttgtga acagcgccga ggtcgcacgg gagcgtacgg 326341 aagagtgcat tcaaaccatt gcgaccatcg cggatcagga gctgaactca cacgtttctt 326401 taaaaatgac gtctttaggt ttggatatag atatggattt ggtgtatgaa aatatgacaa 326461 aaatccttca gacggccgag aaacataaaa tcatggtcac cattgacatg gaggacgaag 326521 tcagatgcca gaaaacgctt gatattttca aagatttcag aaagaaatac gagcatgtga 326581 gcacagtgct gcaagcctat ctgtaccgga cggaaaaaga cattgacgat ttggattctt 326641 taaacccgtt ccttcgcctt gtaaaaggag cttataaaga atcagaaaaa gtagctttcc 326701 cggagaaaag cgatgtcgat gaaaattaca aaaaaatcat ccgaaagcag ctcttaaacg 326761 gtcactatac agcgattgcc acacatgacg acaaaatgat cgactttaca aagcagcttg 326821 ccaaggaaca tggcattgcc aatgacaagt ttgaatttca gatgctgtac ggcatgcggt 326881 cgcaaaccca gctcagcctc gtaaaagaag gttataacat gagagtctac ctgccatacg 326941 gcgaggattg gtacggctac tttatgagac gccttgcaga acgtccgtca aacattgcat 327001 ttgctttcaa aggaatgaca aagaagtaaa aaaggagaga ttatcatgac aacaccttac 327061 aaacacgagc cattcacaaa tttccaagat caaaacaacg tggaagcgtt taaaaaagcg 327121 cttgcgacag taagcgaata tttaggaaaa gactatccgc ttgtcattaa cggcgagaga 327181 gtggaaacgg aagcgaaaat cgtttcaatc aacccagctg ataaagaaga agtcgtcggc 327241 cgagtgtcaa aagcgtctca agagcacgct gagcaagcga ttcaagcggc tgcaaaagca 327301 tttgaagagt ggagatacac gtctcctgaa gagagagcgg ctgtcctgtt ccgcgctgct 327361 gccaaagtcc gcagaagaaa acatgaattc tcagctttgc ttgtgaaaga agcaggaaag 327421 ccttggaacg aggcggatgc cgatacggct gaagcgattg acttcatgga gtattatgca 327481 cgccaaatga tcgaactggc aaaaggcaaa ccggtcaaca gccgtgaagg cgagaaaaac 327541 caatatgtat acacgccgac tggagtgaca gtcgttatcc cgccttggaa cttcttgttt 327601 gcgatcatgg caggcacaac agtggcgccg atcgttactg gaaacacagt ggttctgaaa 327661 cctgcgagtg ctacacctgt tattgcagca aaatttgttg aggtgcttga agagtccgga 327721 ttgccaaaag gcgtagtcaa ctttgttccg ggaagcggag cggaagtagg cgactatctt 327781 gttgaccatc cgaaaacaag ccttatcaca tttacgggat caagagaagt tggtacgaga 327841 attttcgaac gcgcggcgaa ggttcagccg ggccagcagc atttaaagcg tgtcatcgct 327901 gaaatgggcg gtaaagatac ggttgttgtt gatgaggatg cggacattga attagcggct 327961 caatcgatct ttacttcagc attcggcttt gcgggacaaa aatgctctgc aggttcacgt 328021 gcagtagttc atgaaaaagt gtatgatcaa gtattagagc gtgtcattga aattacggaa 328081 tcaaaagtaa cagctaaacc tgacagtgca gatgtttata tgggacctgt cattgaccaa 328141 ggttcttatg ataaaattat gagctatatt gagatcggaa aacaggaagg gcgtttagta 328201 agcggcggta ctggtgatga ttcgaaagga tacttcatca aaccgacgat cttcgctgac 328261 cttgatccga aagcaagact catgcaggaa gaaattttcg gacctgtcgt tgcattttgt 328321 aaagtgtcag actttgatga agctttagaa gtggcaaaca atactgaata tggtttgaca 328381 ggcgcggtta tcacaaacaa ccgcaagcac atcgagcgtg cgaaacagga attccatgtc 328441 ggaaacctat acttcaaccg caactgtaca ggtgctatcg tcggctacca tccgtttggc 328501 ggcttcaaaa tgtcgggaac ggattcaaaa gcaggcgggc cggattactt ggctctgcat 328561 atgcaagcaa aaacaatcag tgaaatgttc taagcgggac taaatgggca tcctccctgc 328621 gggggtgtcc atttcatcca tatactataa aaaagaggag gaagtgccat agaaaacaca 328681 cagctgatta tttcgatttg tatttatatg gcgggaatgc tgctaatcgg ctactttgct 328741 tacaagcgta cgtcgaatct gacggattat atgctgggag gacgctcttt gggtccggca 328801 gtaaccgctc tcagtgccgg cgctgccgat atgagcggct ggctgctaat ggggcttccg 328861 ggcgccatgt tttctactgg tctgagcggc gcttggatcg tcatcggact ttgccttgga 328921 gcgtgggcga actggcttta cgtcgcacca cggctgagaa cctatactga aaaagcgggg 328981 aattctatta caattcccgg attcctggaa aatcgcttcg gagatcaaac aaagcttctc 329041 agactgtttt cgggaattgt cattttagtc tttttcacgt tttatgtatc gtccggaatg 329101 gtgtccggcg gcgtcttatt caacagcatc ttggggatgg attatcacac cggcctgtgg 329161 attgtgacgg gtgttgttgt ggcatatacc ctgtttggcg gctttttggc agtcagctgg 329221 acagattttg ttcaggggat tattatgttt gccgcactca ttcttgtgcc gatcgttacg 329281 tttttccaca cgggaggagc aggtgataca gttgctgaaa tccgctctgt agatcctgat 329341 atgtttaata ttttcaaagg aacgagcgtc cttggcatta tttctttgtt tgcctggggg 329401 ctgggatact ttggccagcc gcatattatt gtgcgtttta tggcgataac gtctgtcaaa 329461 gagatcaaaa gagcgcgcag aattgggatg ggctggatga ttttgtctgc agtaggcgca 329521 gtgctgaccg gtttgggcgg aatcgcttat taccatcagc gcggcatgac actgaaggac 329581 ccagagacga tttttattca attagggaat atcttgttcc atccgattat cacgggtttt 329641 ctgatttcag cgattttggc cgcgattatg agtacaattt cttcccagct gcttgtgaca 329701 tcaagctctc tggtagaaga tttgtataag tcgatgttca gacgctcagc ttcagataaa 329761 gaactggtgt ttttaggccg actggctgtt ctggctgttt caattgtcgc gttggttctg 329821 gcttgggaga aaaataacac catccttgga ttggtcagct acgcgtgggc gggcttcggt 329881 gcatcattcg ggccagttgt actgctcagt ctgttttgga aacgaatgac caaatggggg 329941 gcactcgccg gcatgattgt gggagcagcg actgtaatca tttgggcgaa tgccggtctt 330001 tcggactttc tgtatgaaat gatacctggt tttgctgcga gtctattatc tgtctttttt 330061 gtcagcatat tgacgcaggc tccgtcacaa gctgtcacag accagttcaa cgactaccaa 330121 gatacaatgt cgcaataaag atcgaaagga ggaggaaggg gctgtccctt tttcctcttt 330181 tctcctttta agcggccatt tttttctttt ggaaacaaac gtattttttt ctatacaaaa 330241 agaccccgta tggatatgat taaagtaaaa aaagtatagg agaaaaaggt atggaagagc 330301 ttttagagag agttttttca ttttcagatg ttgataagct aattgatttt attagctatg 330361 aactgcaaaa gccagtgata ctggaaagcg cggatttctt tttgttagcc tataattctt 330421 actatattaa ccattttgat tctgccaacc agcagactat tttttcgaaa aagtgtccgg 330481 tccagatttt tgagaggttt ctgaaggacg gaattattga aaaattgaaa acagagcctg 330541 agccttttcg cgtcaataaa attgaaagca ttgggttaaa ccagagggtg gtcgtgagtg 330601 caaagcacaa aggggaagtc atgggctaca tctggattca ggagctggac caaaatctga 330661 cggatgaaga gctcgacttt ttgtacgaga cctccttcca tgtcgggaaa atcatttata 330721 aaacgaataa attgaaacag gaaaaggaag aaaaagcaga ggatctcatc aaacgggcga 330781 tctatcagca atttacctct gagaaggaac tcagacggga agctgaaagg atcaacaccg 330841 tgctgccttc catgttttca gttgttatcc tgcacgccgc aaatggggat ggggaagcgg 330901 ttgaggattt aaaggaaaat atcaggtcgt acctgaattt acgggataag gtcagtcatg 330961 tcttaacgat cgaatcaaac attgtcatcg tcgtagcgag tttttcccaa aaaagctccg 331021 tctcctcagc agcttctgag tttattaaca agctgttaac acattttcac tttcaaaaaa 331081 tacctacccc tatttatatc ggtatcggaa acgaatataa tcacctatta aaacttggca 331141 agagctacac agaagcactt gaagtcatca aagccgcaga aatcaccggc aatcaggaaa 331201 acattccata tgaatatgcc aaactcggca tttaccgcta tttagaaagc atcgaacaga 331261 aaaatgaatt tttagaatac gagaataaag atttagcttt attaaaagca aaagacgaag 331321 aaagcagcac tgagctgctc aaaaccttgg aaatctatct cctcaacaac tgcaaaacaa 331381 aaccagcggc agaacagctg tttattcacc aaaatacatt gaattaccgc atcaaacaga 331441 ttactgagat gacgtcgatc gatttaagcg atttcagaac gcggtgccag ctctatctcg 331501 atttgatgct gatgaaaaag aaataaaaaa gaaaccagta cttgtactgg tttcgtcttc 331561 acttaaaatc ctctgtaaac atacggatca tcaggttttt taatggtatt ccagtcagtt 331621 actttgacga cagggagagt tgacttgaat ggctggtaat attctgaggc cagagtgccc 331681 ttaatgtgaa tccattcatc atccttgatg tccatgtcct tcggaaattc cacaagcatc 331741 ccgtacacgc cggaatcagc gatacagtga atgatgccaa accttaatac gaacagctga 331801 tttttgttaa ttgcgtttcc tttgtaagca aatccatgaa attctatcgt ccgtccgaga 331861 aattcacccg gatagttata gatggtttcc attcctttta ggaaatcgtc atcggtcaga 331921 gaaatctctt ttttgctgga atacttatta aacagctgtt tcatttgttt gtcatagctg 331981 tcttgcgcgt aataaaggct ggcatcaggc cgcaaatact gtgtttggga gtagtgatct 332041 ccgctctcca tcgccttaaa cgagaaccct tttgttttga ctatggatga gtcaagcgtt 332101 gcaatcggga agaagatgcc tgacaccaaa ggaaaaagaa aaacaacata aatcaaataa 332161 cgctgataaa atggcttgtt ttgttcatgg tcatgctcgt gatcatggcc gcacccgcaa 332221 tcatggtcat ggtgatgtcc gcttttttca ggcgacttga taaatagata tgcttggacg 332281 gcggtcagaa tggccagcag gaagatcgca ataaaggaaa gataggcata tttcatattg 332341 atatattttg ttagatttcc tgaggcatgc agatgataaa agaaaaacgt aaatcccatc 332401 agcaccaata aacgaaacat ccaatcaccc ctttaccagt agtgatcccg ctaaaacaat 332461 cacgacaatg tatgtaatca gcaggaaaac aaatcgtttt ttgaaggccg caagcatcat 332521 caatagattc ttaatatcca ccattgcacc aaagacgaga aaggcgatta acgatcctaa 332581 tgaaaacgtg ctgctgaagg aagacgcgat gaacgcatca acttctgaac aaagcgacag 332641 gacaaacgcc agacccatca tcacgaggga agaggataca tcattctgcc cgatcgcaag 332701 cagagtggat gttttgacat acgtctgcat agcggctgcg ataaaggcgc cgatgattaa 332761 atatttcccc acggagaaaa attcatcaat ggcatgccgc aaggtcccgc ccagtttttg 332821 gagcaaggtg ccgtgatgat gatggtggtg cccgggttca tcaggcttta aaagctggtt 332881 atccttaaat tgataggata agatgacccc gatgatcagc gaaacggcga gagccagtcc 332941 gcctctgtaa aagaccacgc tccatctatt cccgaacgca atataagtag aaaataaaac 333001 gataggatta atgataggcg cggtcagcat gaaagcaacg cccgcatgca gaggaactcc 333061 ctttaacaga agccgcctcg taatcgggat gatgccgcat tcgcaggcgg gaaataaaac 333121 gccggccagc gcaccgaata aaacggcgag aaaacggttt ttcggcatga ttcttgcaat 333181 catttcttca gaaacaaaca tttgaatgat tccggaaagt atgacgccaa tcagaataaa 333241 cggaatggct tctattaaaa tgctgataaa aatagaattc agctgaagaa aagatgattg 333301 tgctgtcaca ataaaacctc cgctcatgtt aagctgcctt tcttatgata ccagaaaaaa 333361 aggcactgct tgtttgacgg aggaggggaa aggatcgttt cactttggtt aggattccaa 333421 aaagccgagt aggatactgc ctgtttctgc agcttctttt ccgagccaaa tcaggtgtcc 333481 ccatgagtga agcaaacaga gaacagcgcc acgaatgtgc tcttttgcat gatgtgcatg 333541 tgacaagtca accaatccgt cataaacact ttgcataatc agcacgggac atatgatggc 333601 ttgcaggtct tttaaagaga cagcggcggt ttgtgacaag tcaatcagaa atccttcacc 333661 cgagcgctgc cggctgttca ttttccgaaa tgcttctatg tctttttcat tcatcaagga 333721 cttgattcgc tgaaacggaa gcgtgctgaa ttgggggctc atagctcgaa acatcaaacg 333781 cgggaaagcg ttattcaagg aagaaatcag cttccatatc cacttttcca ccggcgggcg 333841 gaagagaatt tcccccaatt tatattcagt gtcttttggg gtgagccact ctttggtgac 333901 tgcggattgc agggtcaatg tatttactct ttccggataa tgtgaggcaa agcatatgcc 333961 gctcggccct cctgctgaga tggcgatcac atggacactc tcgatttgta gatgatctaa 334021 taatttcaca tagaaacggc aggcattggc aagacttttt ccaatttctt ttgacgtccg 334081 tccatagcca ggccttgaag gcgtaatgat ggaataccct tgttcaatca acgctgtgta 334141 tccgaattcc tcgtaacaat ttgaatgccc gccatgcatg acaaggatcg gagttccctt 334201 gcctgtcaca gaatattcta gtgtaccgcc atcgaaggtg atcgtttcaa ctcgtctttt 334261 catctgtttc acccaattgg tttttgccta ttatagagtt ttcagcaatt gaccacaagg 334321 tagaagaaat gaataaacaa aggcccttga aatatgatat actttgtatt gatattcatt 334381 ctcaattaaa actttgatat agatgtgaac gggaggcagg acggatggct gagaatcaag 334441 aggtatatga cgttacgatt ataggcgggg ggccgatcgg gctgtttact gctttttact 334501 gcgggatgcg ggagctgaaa acaaaggtaa tcgaattttt gccgaagctc ggagggaagg 334561 tgtctttatt ctttcctgag aaaatcattc gcgatatcgg cggcataccg gggattgcgg 334621 gaaagcagct gatcgagcag ctgaaggagc aggcggcaac gtttgatcct gatatcgtat 334681 tgaatcagcg tgtgaccggg tttgaacgcc tagatgacgg caccattgtt ctgacgggtt 334741 ctgaagggaa aaagcactat acaagaactg tgattttggc ttgcggcatg ggtacacttg 334801 aggtcaatga gtttgacagc gaggatgcgg cccgatatgc gggcaaaaat cttcattatg 334861 gagtggagaa gctcgatgcg tttaaaggga aacgcgtggt gatatcaggc ggcggagata 334921 ctgcggtcga ttgggctaat gagcttgaac cgattgcggc gtctgtgact gtcgttcatc 334981 ggcgtgagga attcggcgga atggaaagca gcgtgacgaa aatgaagcaa tcatcggtgc 335041 gggtgcttac gccttatcgg ctggagcagt tgaacggaga tgaagagggc atcaaaagcg 335101 tgaccgtttg tcatactgag tctggccaga ggaaagacat agaaattgat gagctgatca 335161 ttaatcatgg gttcaaaatt gatctcgggc cgatgatgga gtgggggctg gagattgaag 335221 aaggaagggt gaaagctgac agacatatgc gaacgaatct tccgggcgtg tttgtggcgg 335281 gcgacgcggc tttttatgaa agcaagctga gattgattgc cggcggattt acggaaggcc 335341 cgacagcggt caacagtgcc aaggcttatc tggaccctaa ggccgagaat atggcgatgt 335401 attccaccca tcataaaaaa ttggtgcata aataaaacag cccttgagga aaagggctgc 335461 ttgccatcag gtgtgaagga gttttttctc tgcatgttga ttgtggatga aagctagcaa 335521 ttcatcctgt tcttgtacgg ctgtgaatcc ataaatgccg gcagctgagt catcgcctat 335581 gcagacgata ggagggcggc ttgctgacgg ttccggcaaa atgccaattt gttcgccacc 335641 attgatcaat tgctgaacgg acagcttgtt tgggcaaatg accatgtgca gcggggattc 335701 actgatggta cgctgaatca tgtgggtgaa ccggtcatct atgacgtttt catgagtgat 335761 ataaaacgaa caggattcat gcttttgcat gttttccact gcatggcggc tcccgacaac 335821 aagacgtttc tctgaatcag gctgaatggc ggtgacaaga aagccccgtt tctcaagctc 335881 tgtctttgct tgctcagatg ctgcactcag tttggctgtc agctggcgga tgtcgatttt 335941 ctgagaagcc agtgctctga aaaattcaca aaccgcccgg cgcgatgtga aaaaaacgtc 336001 ttcaaaggtg ccaatctttc gaagaatttc ttcattgaca ggcatgtttt cggtccgcca 336061 tttcggccac tcgatgagat cggcgccgga atcgcgcagc ttgtctgcaa gcgggtcttc 336121 atcttcgcca tgagtcacaa ccatcaaatg ccgtccgatg agcggtttgc tttcaaacca 336181 gctgtgtgtt tgaaagttga cgatgtctcc gatgacgata atcgcagggt ttgtaatctg 336241 gtgttcctgc actttttgct gaatgttctc aagtgttcct ttcacactcc gctggcggcc 336301 ccacgttccc cattggatga caatgacagg gacagaaggc gatttcccgt atgaaataag 336361 ctgctggcaa atataagaca agttcttgac acccatgtaa aaaacaaggg tttgaacgct 336421 tcgggccagc ccttcccagt caaggttcgg cgtgcctttt aatgatttat catgcgctgt 336481 aatcatggca aaagacgatg caaaatcccg atgcgtgacg gggatgcccg catatagcgg 336541 cgctgcaatt ccagaggtga ttcccggcac catttcatag cgaatgccgt gctcatgaag 336601 agcatctgct tcctcgccga ctctgccgaa tacgctcgga tctccgccct tcaagcgaac 336661 gacggttaac ccatttaatg ctttttcaac cagcagggcg ttaatttctt tttgtttcat 336721 aaaatggcgg tttggcagtt ttccgcaata aataaactgg cagtccggtg atgcaaattc 336781 gagcagcttc gggttggcga gccggtcata taaaatcaca tctgcttcct tgagcgcctg 336841 ttttcctttg atggtgagca ggcctgggtc gccgggtccg gctcccacga aatatacgat 336901 tccgttcttc atgatcatgt catccttccg tcactgtaaa aaatgaagga ccactagaaa 336961 agtgatccgg tcttttgatc aatatacgag ataaacatgt tctccttcga tcagcgtttc 337021 atatgttttg acgcatccgt ggtcaggttc ttggacgatt ccgtcttcta aggaaatttt 337081 ccagtcgtgc atcgggcaga aaacatattg accgctgacg atgccttctg ccaggacgcc 337141 gcccttatgc ggacagcggt tttcaatggc gcggatgctt ccgtctgaaa gcttgaaaac 337201 cgcgagctcc ttatcttcaa tatacactgt tttgcctaat tgttcaggca attcttcaat 337261 ttttccgata catacttttg ttacgtcttt gtttaccatg tccattcctc ctcaatgata 337321 gtttttgtca ttatgatgtg gtcacgacat tttcaaataa ttctttagag gtttgtttat 337381 cctctaaaaa gtctttccac ggatccttgt ggacagagag tgtttcattc attcggccgt 337441 tcagctcctg ccgcttttcc ggatcgttta acacggattg gacatgggat aaaccgacgc 337501 gctcaagcca tgcggacgta cgctccagat agtttgcggt ttccctgtaa tattgcaggt 337561 aagcgcccgc gtattctaag acttcttcat ttgttttcac cttcatcagc aaatcgccgg 337621 cacgcaaatg ggttccgccg tttccgccga cataaagctc ccagcctccg tcgatgccga 337681 caacgccaag gtccttaatg ccggattccg cacagtttcg cgggcaggca gacacggcca 337741 ttttgacttt gtgaggcgtg ttcagccctt cgaatttttt ctcaagcgca atgcccagtg 337801 ccatggagtc ttgtgtgccg aagcggcaga attgctcgcc tacacatgtt ttcactgtgc 337861 ggagcgtttt tccgtacgcg tagcccgatg gcatatcaag atcttcccat accttcggaa 337921 ggtcttcttt tttcacgccg ataagatcaa ttcgctggcc gcctgtcatt ttcacgagcg 337981 ggatctcata tttgtcaacg acatcggcga tcttgcgcaa atctgtggag ttggtcacgc 338041 cgccgtacat ccgaggaacg actgagtatg ttccgtcttt ttgaatattg gcgtgcattc 338101 gttcattaac aaagcgggat gtccggtcat cctcgtattt ggttggattg atcatgccta 338161 agtagtagtt cagagcgggt cggcatttag aacagccttc tggcgttttc cagccgagca 338221 cattcatgac ttctcttgta tgtgacagcc ctttggcttt gatttcttct acgacttcat 338281 ctctcgacaa tgtggtgcag ccgcaaatgg cttctttttg cgctgacgca tcaaagtctg 338341 atccgagcgt atgctggagg atttcttcta cgagcggctt acagcctccg catgagcggg 338401 atgcgccggt gcatgctttg atttcgtccg ttgacgagca gcccttttcc tgtatggctt 338461 gaataatcgc accttttgac acgccgttac agccgcagat gatttcatcg tcgctcatcg 338521 ctgcggttat gcttgtgcct gcttcctggc tgaggggctg taagattgat attttagagg 338581 tttcagagat atcggcttct ttttgaatca tagaaaacag gcgattgcct tcgctgctgt 338641 cgccgaataa aacagcaccg acaatttgat tgcctctcag gacaattttt ttatagatgc 338701 cgtcctgctc atcgaagact ttaatcgctt ttttctcctc tgattcgtta aagtcaccgg 338761 cagagaagac ctcgacgcct gataccttta actgtgtgga gagaacggag ccctcatacg 338821 gttttgtttc gatgccgcac atatgctttg ccagcacttt tgcctgttca tacagcggcg 338881 ccacaagccc gtaggcgatt cctcggtgct cggcacattc gccgaccgcg taaatgtgcg 338941 ggatttcagt ctgcatataa tcgttgacga tgatgccgcg gttaaccgga atgccgctct 339001 cggccccgag cgttgtattt gggcggatgc cgacagccat gacgactaaa tcagcttcaa 339061 tgcttgtgcc atccttgaat cggaggcctt cgacacggtc gtcaccgaca atttcttctg 339121 tttgcttttc aagtaaaaag gtcatacctt gtttttctaa ctcgttttgc agcaggcgtc 339181 ctgccgttgc atcaagctgg cgctccatca ggaatggggc aaggtggatg acggacacgt 339241 ccatgccgag attcagcagt ccgcgagctg cttccaaacc aagtagtcct ccgccgatga 339301 cggcagcttt tttatattgt tttgacgcgg cgagcattgt gtctgtatct tttatgtccc 339361 ggaaagctgt gacgcctttt ttgtctgcgc ccggaatcgg aaggataaaa gggaccgatc 339421 ctgtcgccag gatcaattca tcgtaaggct ggattctgtc tgcatctgtg atgactgttt 339481 tgttttccgt gtccactttg atgactgttt catttgtata caattgaatg ttgttttctt 339541 cgtaccagtc ccaatcgttt aacgtaatat ctttaatatc tgtatcgcct tgaagcactt 339601 ttgacaaaag gattcggttg taattgggat gcggttcggc accgaaaatt gtgatctgaa 339661 actcgtcttt agcaacactc agtatctctt caatggccct taccccggcc attccattac 339721 caacaagaac tagctgtttt tttcccatca gatgatccgc tccttatcaa atgttttttc 339781 cagcgtagca cagcaaaaag gaatatttaa gatacatgtt ataaaatgta acaaaatata 339841 cgaaaagttc taaaaatttt atgaaaaatt taaataggta tgattcggac ggcgcatacc 339901 ttaaaaccgg gcattttaca ggctggatct aaggcttccc cgattaaatc attcacattt 339961 tgagcgtctg cccaatggat gggaacaaaa acggtatctt ttctgatttg ttctgataat 340021 ttgctgcgga cggtgatgct tccccgcggc gattctattt ttaccagtac acggtcctcg 340081 atattgtagg tcgctgctgt ttgcggatgg atctccataa acgattcaaa atgtctcgcg 340141 gcaagggcgg cgctttttct tgtttggacg cctgttaagt agtgagacat gactctgcct 340201 gtcgttaaat aaagcggata atcggctgtc ggcttctctt ttggaacagg tggttcgttt 340261 ggaatcacac ttaatgccgc tttttgatcc ggatgagcaa atgattctgt aaacaagcgc 340321 ccagttccgg gatgatcaga ttccggacac ggccaatgaa tgccgccttc acgtctgagc 340381 ctgccgtatg agatgcctga ataatcggca atcccgcctc ggctcgcttc tctcaattca 340441 ttgaaaatat cctccgctga cgtataagaa aagtagcggc ccttgccgag agcggatgcg 340501 agatcacaaa tgatctgcca atcatgcttt gcttcgccgg ggcatggccg gcttgcttct 340561 cttaatgtca cgcgtccttc tacatttgtc atggtgcctt catcttctaa gtaagaggag 340621 gcaggtaaaa tcacatctgc gtatttcgca gtctcagaaa taaacaaatc gattgcgaca 340681 aagaatgtca gtcttcttaa agcctttttc acgagatttg catttggact ggaaacagca 340741 gggttggagc acatgaggaa cagtcctttg atgtcgccgt cattgatttt ttccatcatt 340801 tcataggctg agacaccttt tcgcgggagt tcatcctgat ggattcccca cactttcgca 340861 atatgcgccc ggtgttcttc gttttcgata gaacggtagc ctggaagctg atcggctttt 340921 tggccatgct ctctggcgcc ttgcccgttg ccttgtccgg tgatcgcccc gtagcccgag 340981 taaggtttgc cgatttttcc tgtgatcagc accatgttta agaagccttt cacagccgct 341041 gttccatcgg tttgctgttc aatcccgcgg gctgtaaaca gcatgccgga cgtttccttg 341101 gcaaacttca cagcagcttt tcttatatcc accagcgaga cactcgtctg ttcggcgatg 341161 tcattcaggt ccaacgagtc agtatgctgc ttcagctctt cgaatccatt tgttcgtgat 341221 tgaatgaaat cctcgtttat aagctgttcg tcaatgatga ttttgacgag accgttggca 341281 agggcggcgt ctgtgccggg tttgattttc agatgaagat cggcgatttt cgttgtcgct 341341 gtttcacgag gatcaatggc aatgaagtaa gctccgtttt ctttcgcttt ttcaaaatac 341401 ggcataatcg taggctggca ttccgcaata ttggtgccgg ccagaatgat cacacgggtg 341461 tgggggatgt ctgataaagg attcgttaag cctctgtccg cgccgaatgt ttggttggct 341521 gcggtggctg ctgcggacat acaaagtctc ccgttgtagt cgatgtattt tgtctgtaag 341581 cctactcgtg cgaacttccc taacaaatac gcctcttcat ttgtaatcga ggcgcttccg 341641 tataccgcca tggcgtcatg tccgtgttca gtttggatca ttgtcacttg gtctttgata 341701 tgattcagtg cttcttccca ggaaacaggc ataaactcgc cgtttttctt cagcagcggc 341761 cgggtgatgc gggaggagtt caaggcatgc tggtgagcat tcatgccctt gatgcatagc 341821 cgaccctgtg tcgtaggatt atcaatcccg atcgcagtgt actttttgcg cgtgacgatg 341881 gtttgttcca cgagctgcat tttgcactgc atgctgcaaa acgggcattg agtgtcatat 341941 gttttttctg attggacgtc ttgctgttta tcacggaaat atctaagcag tcgttcagtc 342001 aaaatgcctc atcctttctt atatgcgccc gtctctacag tcgggttttg aatcagtgac 342061 agatctgttt ggaggctttc cagcagctgt gcccttaggt cttcttcgaa tagcacttct 342121 ctgatatgaa cgatcccgag acggtctatc cactgatgaa caccttctaa gtaatgagcc 342181 gtttcccgat aatactggat cagtcctttg atcatgccgg cagtgctgtc ttcgttctca 342241 gtcacgcaaa acaaagctcc tgaacgggca tgagttcccc ggacgccgcc gatgtgaatg 342301 tcccagccag cttgtgtccg aattgcgccg acatcttgca gggcggcctc ggtgcagtct 342361 gtttcacatg ataagctgat agaaatggga gcgggtaagg gaagcatctc aagttgtctt 342421 tcgatttggg ctgccagctg ctgaatcgat cgattttgcc cgcatgtaca tgctttgatg 342481 ctttgcagcg cgtgtcggtg ttcattagtg taaacgggca ttttcaggtc ttttttcatg 342541 ttcgggagat ccgcaggctt gatcccggaa agcttcagcc tttggccgtg agtgatggat 342601 acgtcgggaa tgctgtatgc ctcaatgatg ttggcgatgg ttcttagctg ctccgcgttt 342661 gtccgcccgc cgtacatttg cggaatcagg atgcatgtct cttcagtggc tggctcaggc 342721 tggacaaacc cagggtacag catttccaga tagtattgaa tcgcaggaac acaagtactg 342781 catccgtttt ttgttttcca gtcaagctgg ttcatcactt ctgccggatt agtgaatggc 342841 ctgcgctgaa gctcagcgat gatgtcgtct tctgtaaaat cagtacagct gcaaaacgaa 342901 ggtgtgctgg cgggcttcgt atattcgctg ttggtcatgt atctcaaaag gtcttcaacg 342961 agcggtttgc atcctccgca ggacccagtg gctttggtgc agtgcttgac ttcctcaaca 343021 gttgttaagc tattcgtgtg caccgcgtct tcaatcgcgc ctttcgtcac tgtgttgcat 343081 tggcaaatcg tttcactgga aggcatggat tcaaataaag ggccgcttgt ctccggttcg 343141 atgatctgtt ttttggcaat ggagatgtct cgttgtttaa gcaggctgtc gagaagccgc 343201 tgcttgtcac gggtgtctcc gaataaaata acgccggcca gtttgtcatc tacaaaaagc 343261 gcttttttat aaacgcctgc ttgttcgtcg tagattttga tgctcgtcgt gcgttcatcc 343321 tcttggatct ttcctgctga ccacacatcg attccagcta tttttaacgc cgcagatggt 343381 gctgagcctt gatattcctc acatggaacg ccgcaaatat gactggcgag cgcttttccc 343441 tgctcataaa gcggagccac caatccgtac accgttccgt tatgctcagc gcattcacca 343501 acggcgtaga tattcggttc gcttgtctgc atgaagtcat tcacgatgat cccgcggttc 343561 actttgattc cagcggatac agccaattca atattcggtt tgacgccggc cgccatcaca 343621 atcaagtctg cttttaatga agagccatct ttaaaatgga ttcggtctgc cttcgtggcg 343681 ccggaaatgg agacggtgtc tttctccaaa agaaaggtta ggcctttttg ttccagctct 343741 gtttgcagca gccgcgccgc tgtttgatcg agctgttttt gcataatgcc ggcggagtgg 343801 tgaatgacgc tgacatccat accgagatgc tgtaaaccta ctgcagcttc cagtcctaat 343861 aagccggctc cgattaccgc agccttttga aagtgctggg ccatgttcat cagcgcttgg 343921 cagtcttcta ttgtccgaaa tccatagaca ccttttttgt ctgccccggg gatagggaga 343981 atatgagggg aggagcctgt tgccactatt aatttgtcat acgacagagt gcgtttccga 344041 tctgtgatga cctgctgctg atctgtatca atctgaataa ccgtttcgcc tgtgtaaagc 344101 gtgatcccgt gcttgtcgta ccaatccttg ctgttcagtg taatatcatc gagtgacgct 344161 tcaccctgca atacagagga taagagaatg cgattgtaat tgggatgcgg ctcgcttccg 344221 aaaatgacaa tctcaaacat gtggcgattc agctttaata cttcttcaat acagcggatt 344281 ccggccatgc cgtttcccgc taacactaat ctttgtttct tcatgtatca gacctccttt 344341 ggcgaagctc gtaagttttc tcctattaaa aattatgtca caatgcattg ttaacgcatt 344401 aaacgtgtca caaaaactta cacatgtctt ttccagaaaa taatggtcct atatccttga 344461 ttcagaaaat gtaaaataat gagggtctag aaaggggaat cttatgaagc tgtcggaact 344521 gaaaactagc ggtcatccac tcactttgct ctgttccttt ttatactttg atgtcagttt 344581 tatgatatgg gttatgcttg gggcgctggg tgtttatatt tctcaggatt ttggcctgtc 344641 tccttttgag aaagggcttg tcgtagctgt gccgatttta tctggatctg tgtttcgtat 344701 cattcttggt attttaacgg acagaatcgg accgaaaaaa acggcagtga tcgggatgct 344761 ggtgacgatg attccgctgc tttgggggac attcggcggc cgttccctga ctgagctgta 344821 tgccatcggg attctgcttg gcgtggcggg agcaagcttt gctgtagcgc tgcctatggc 344881 cagccgctgg tatccgcctc atttgcaggg acttgcgatg gggattgccg gagcggggaa 344941 cagcggcacg ttgtttgcaa ccctgtttgg ccctcgtctg gcagagcagt tcggctggca 345001 cattgtcatg ggaattgcgc taattccatt attgatcgtc tttattcttt ttgtatccat 345061 ggcaaaggat tcccctgcac agccgtctcc ccagccgctc aaaagctatc tgcatgtgtt 345121 tgggcaaaag gaaacatggt ttttctgcct gctgtacagc gtcacatttg gcggatttgt 345181 cgggctctca agctttttat ctattttctt tgttgatcaa taccagctgt caaaaattca 345241 cgcaggggac ttcgttacat tatgtgtggc ggcggggagc tttttccggc ctgtcggggg 345301 cttgatttca gatcgtgtcg gcggcacgaa agttctttct gtattgtttg tcatcgtggc 345361 actgtgtatg gccggagtca gtagcctgcc atctctctca atggttattg ttctattgtt 345421 tgtcggaatg atggggctcg gaatgggaaa cggcgcagta ttccagctcg tgccgcagcg 345481 cttccgcaaa gaaatcggca tggtgacggg aatcgtcggt gcggccggag gaatcggagg 345541 gtttttcttg ccgaacatct taggatctct caaacagatg acaggcacat atgctatcgg 345601 ttttatcacg ttttcctgta tcgcgctgct ggcgtttgca cttgtgcttg ccgcaggcta 345661 ttactggcgg aaaagctgga gcgcggaaag cagcccggcg gatgtttagg attttgacgg 345721 acacgcgttt gtgcgtgtct tttttatttt ctcttgattt tcaacagtga accgatcaaa 345781 ataaatagta attattacga tttgttagtg agaggagttt tctgaatgaa tcaacatacg 345841 ctgctcccga aaaaaacgga gcgtcttcaa tactttggat cggtcagtcc gatcaaaggc 345901 gagaaaccag tggaaaaaga gaaaatgaag gacctgcaaa atatcaggaa ggattatttt 345961 tttgacattc agcatgtagg tgtagctaat gtgtcccatc cagtcacaat cacttctgcc 346021 atgatgcctg ccgagcaaac aacggctgcg aactttacaa tgacttgtaa tttgccgaga 346081 aatcagaagg ggattaacat gagccggtta acagagctgc tgcaagtcta tcatcaaaat 346141 ggctggattc tctcattttc ctctcttcag caatttacga aagagcttgc agaaaacatg 346201 gacacatcat ctgccacagt tgaagtgagg tttccgtggt ttttcgaacg gaaaagcccg 346261 aagcttgaga aagcgggttt gatgcatgct gatatattca tgtctgtcac ctatcgcaaa 346321 gatcagccgt ttaaacagcg tgccggcatc tcagcaaaag taacgactct gtgcccttgc 346381 tccaaggaaa tcagcgaata cagtgcccat aatcagaggg gaacggtcag catttgggcg 346441 gatattcacc cggccgcatc gctgccaagt gatgttaaag ctgatttgct tcacgccgca 346501 gaatcaaatg cttctgcgag actgcatccg gtattgaagc ggcctgatga aaaagccgtg 346561 acagaaacgg cctatgaaaa cccgagattt gttgaggatc tcgcccggct gattgctgca 346621 gatttgtttg agcttgaatg ggtgtcagcc tttgagattg aatgccgaaa tgaagaatcg 346681 atccatcttc acgatgccta tgcgaagctg tgtttttcga aggaagtgga taaaatatga 346741 aactctcatt attcattatt gcagttctta tgccagtcat cctgctgtca gcctgctccg 346801 atcatgcaga agaacacgca agtatcaata caaagaaaac ggtcgaaaac ataacggacg 346861 ttcgaaaaac agcaaaaaca agcattgatt ggacaaagcc ttcgggcgga gaatacccgg 346921 atattaaaca gaagcatgtc tggattgatg tgaatgtgaa ggagcagaag gcttacatca 346981 aggaaggaag caacaccatc tatacaatga tgatttcttc tggtcttgat caaacaaaag 347041 atgatgctac gccaaagggc accttttatg tagagcctga acggggagaa tggtttttct 347101 ccgaaggata ccaggaaggc gcagaatact gggtatcatg gaaaaatcac ggtgaatttt 347161 tatttcatag tgtgccaatg actaaggatc aaaaagtcat caaaacggaa gcagaaaaac 347221 taggaacgaa agcatctcac ggatgtatca ggctgaccat tccagatgcg aaatgggtat 347281 atgaaaatat ccctgaacat acaaaagtgg tgatcagctg aattgaaaac cgttgacaaa 347341 aaggaaaaaa gaccatacaa tttaaatcgt aacaattacg ttttatgata aatggcttat 347401 cattgtctgt gcatctgtga aaagcggaaa ggcatcgatt aaggatcttg ctgtcggcaa 347461 aggcaaggat ttgcgatggg gaaaaggatt aaacgcggtt ggagtcttta ctgatttaga 347521 aatcgggcgg cagcgagaaa tgagcgcgaa aagctgctct acaccattgt acatacggcg 347581 aagtattcaa tttaaatcgt aatcattcta ttttaatgga ggcactatta tgaaaaaaat 347641 tccggttacc gtactgagcg gttatctcgg tgcgggaaaa acaacattgc tgaacagcat 347701 tttgcaaaat cgcgaaggct tgaaaatagc ggttatcgta aacgatatga gcgaggtgaa 347761 cattgacgcg ggcttggtta agcaggaagg tggcctttcc agaacagatg aaaagcttgt 347821 ggaaatgtca aatggctgca tttgctgcac gcttcgcgaa gacttattaa ttgaagttga 347881 gaagctggca aaagacggac ggtttgatta tatcgtcatc gaatcgacag gaatcagcga 347941 accgatcccg gtggcccaga ctttctctta tatcgatgaa gagatgggaa tcgatcttac 348001 aaaattctgt cagctggata cgatggtgac ggttgttgat gccaaccgtt tttggcatga 348061 ttatcagtca ggcgaaagcc ttctggaccg caaagaagca ttgggggaaa aggatgaaag 348121 agaaatcgcc gacctcttga tcgatcaaat tgagttttgc gatgtactga tcttaaataa 348181 atgtgatttg gtcagcgagc aagagctcga acagcttgaa aacgttcttc gtaaactgca 348241 gccaagagcc aggttcattc gttccgtcaa aggaaatgta aaaccgcagg agattttgca 348301 tacagggtta tttaacttcg aggaagcgag cggatcggcc ggctggattc aagagctgac 348361 ggcaggccat gcggaacaca ccccggaaac agaagaatac ggtatctctt catttgtata 348421 taagagacgt ttgccgtttc attctacacg attttaccgt tggttggatc aaatgccaaa 348481 gaacgtggta cgtgccaaag gaatcgtctg gtgcgcatct cataacaacc tcgctttgct 348541 gatgtcgcaa gcaggtccgt cggttacgat tgagcctgta tcttattggg tggcggcgtt 348601 gccgaagctt gagcaggagc aagtcaaaca gcaggagccg gaaatcctgg aggagtggga 348661 cccggagttc ggcgaccgcc taacgcagct agtttttatc ggaactgacc tggatgaaga 348721 aacgatcacg aaagagcttg atcaatgcct gttgactgag tatgaatttg attccgactg 348781 gtcgctgttt gaggacccgt ttaaatggaa gctgaatcaa tagaaaaaaa gccgtcccat 348841 ggggaacggc tttttttaat gaaacgtttg tttaaacata atgagcgtat tttttctcaa 348901 ggatattctg aaagaccgcg gcaatggagc agatggccca ataaatgaga gcggtcagaa 348961 tatacatggt catataatca aactctctgc ccccgatgat tttcgcatgc tggagcaatt 349021 ccggcactgt aatcatcgca gcgagagagg acgccttgat caagtcgagc aatacattgg 349081 caagcggagg cagcgcaata cgtatcgatt gcggcaaaat gatgcccctc atcgtctgcc 349141 aataggaaag acccagcgag gatgcggctt cccactgtcc tttttcgacg gatgaaatgg 349201 ctgaacggtt aatttccgca atgtaggcgg cgctgtttag gctaaagccg attaaagcag 349261 ccgtgacagc ggaaaattca atgccgatat aaggaaaccc gaaataaagg ataaacaaaa 349321 tcaccaaaat cggaacgcct cgcataaatg agatatagag cttcgccggc catcttaaca 349381 aagcaagttt agacattctg gcgagtgata tgaacaggcc gatcacagtt cccgcaaaca 349441 tgcttacaaa agagatgagc agtgtataac caatgccttt tatgacataa gggaacgatt 349501 caatggccag cttcgtgttg aaaatatatt cccactgaat gctattgatc atggcgtccg 349561 attacaaatc aacgtcctga acgtcggcat caattttttt tgatacatct gctttattga 349621 agaattgttt cgacagttta gtcaaagagc catccttgct catctctttc aatgcttcgt 349681 tcatcttttt ctgaagtgcc gcattgcttt ttttcatgac aagggcctgt ttgttcggca 349741 tgtacttgat gtcaggatga attgtaatgt tgagatccgg gaatgccgcg agcgcaagtg 349801 tctgcaggta atagtcgttt aaaatgacgt cagtgcgtcc gttggcaaca tcttttaaat 349861 attgctcatt cgtcgcatta tcataaatca cttctttggc gccgtatttt ctcgcgacct 349921 ccatgtagac ggttgtagcc gcgccagccg ctttcttccc ttttaaatcc ttgagcgttt 349981 taatccctga taaatcgtct tttcggacaa ttgccgtgcc gtatgaatat ttatatggag 350041 tggaaaatgc gaacttctcc tcacggtcct tcgtcacatc gatgtcattc gcggctgcgt 350101 caacctgtcc gctgttcacc gctgtcagca tcccgtcaat gcccatctcc ttgaactcaa 350161 ccttcagccc caagcgtttt gccgcttcac gaacaacttc aacctcgtag cccgtcagct 350221 tatcagagcc agagtcagta tcgtgataag aagtgggata gagcgtacct gatgtagcga 350281 ctacgatttt ccctttatcc ttaatctgct cccagcctgt atccttggaa tcggcttcat 350341 ttttgccgga acaggctgcc aatataagaa agaaagccat tgtgaaactg aatataacgg 350401 ctttggaatg catgaatgat ttcacctata gttcccccaa tctgttaatc aactaaaaag 350461 atagcattga acataagggg ttgcaatatg ttgatcgcgt tttcaaaaag ttcgaattgt 350521 gtatacaaaa agcatgggtg ggtgtttaaa agcgtctatg aagggaagag gtgatgaaaa 350581 aaggaattgt ccaaggatga atgccagacg taccaaggaa acgcatgtga aagtgaagga 350641 tgcagcagac ccgtcactca tctatgccaa taccggaaga aatggtcaag aggcatgaaa 350701 ccgatcttca gaataaattt aagtcttgct gatgccccta aggcatatga tatattcgat 350761 gagaaagaaa atggaaacat ttaaaccata atggggagtc aaatgaatat ttacaaacca 350821 gccggatttt ggatcagact tggagctgca ttgttagact acattatagt ctccgtgccg 350881 cttttgctga tctattggct gattacagga aaagacccaa acgacagcat gttcatcagt 350941 ttggttgttc tgctgtattc tattttgctg ccgatgtttt ggcgcggtta tcttatcgga 351001 aaaaggatct gcggaatcag aatcgtaaaa aaagacggat cacaggtcag tctgttaaca 351061 atgtttttac gggttattgt agccggcctg gtttactgta taaccttcgg actcggcttg 351121 atcgccagcc tgattctgat tgccgtacga gaagacaaac ggaccctgca tgatttaatc 351181 gcgggaacat atgtcactta tgcgacacca ggtgaagagg aacttaatgc tgacgaagag 351241 attagaaaga gcgaataatg gttcgctctt tttattttta tgcataaaaa atacaaggca 351301 gcaaaacata tgaaaaatag gattggagga ataaaatgga tgaaacgaat aaccatcaac 351361 attatcacaa tgttcattgc agcggctgtc atttctctga ccggtacagc tgaggccgct 351421 gaaaaacagc agcagtctcc cgcaaatgtt acactgacag atcagcaaaa gaaagagatt 351481 gaacaactgg aagcagagat tcttaaaaag cgcaaagacg tgatctcaaa gtatgtacaa 351541 tacggtatcc tgcctaaaga aagaggagaa cacatcaaaa atcacttgga caaacacttt 351601 gaaatgatga aacaaaacgg ctttgttcca aagcaccatc ctcatccgca taaatttgaa 351661 aaaagacatt aagattttaa gcatccaatg ggaattgggt gcttttgcgt tatttacagg 351721 taggcaatat tagctgagct gttccgcgac taacatcgag ttgatatgaa acgcgtttca 351781 tagcctatga taggtttatc aaataattca ggagtgataa acactatgat ccaccagcat 351841 ccagaatctt ttccgaaaca ttttttgtgg ggctctgctt ctgcagcgta ccagattgaa 351901 ggcgcttgga atgaagatgg caaaggccct tctgtttggg atgtgtttac gaaaataccg 351961 ggcaaaacgt ttaaaggaac caatggcgag attgcggttg accattatca ccgatttaaa 352021 gaagatgtcg ctctgatggc tgagatgggg ttaaaagcat atcgattttc cgtcagctgg 352081 ccacgggttt ttccaaaagg aaaaggagag atcaatgaag caggtctagc gttttacgat 352141 agtctgattg atgaattgct ttctcatcac atcgagccgg ttctgacttt atatcactgg 352201 gatttgcctc aagcgcttat ggacgaatac ggcgggtttg aatccagaaa catcatagag 352261 gattttaatc actactgtat tactctttat aaacgttttg gagacagggt gaaatattgg 352321 gttacgttaa acgaacagaa ctacaatttt aatcacggat ttattacagc catgcatccg 352381 cctggagtga aagacagaaa acgattttac gaagcaaacc atattgcgtt tctggctaat 352441 gcaaaagcca tcgaatcatt tagagaatat gtgcctgaag gcaaaatagg tcctagcttt 352501 gcttattctc cggcttaccc tttatcaagt catccagagg atatactggc atttgaaaac 352561 gccgaagaat ttacgaacaa ttggtggctt gacatgtatt gctggggaac ctacccgcaa 352621 attccattcc gctgcttgga aaaacaggga tgggcgccga caattgaagc aggagatatg 352681 gacctgctcg ccaaagggaa gcctgatttt gtaggtgtca attattatca gacgatcacc 352741 tatgaacgaa atccgcttga tggtgtgtca gaagggaaaa tgaatacgac aggccaaaag 352801 ggaaccaatc aggagacggg gatacccgga gtgttcaaaa cgaaaaaaaa tccgcatctg 352861 acaacgagca actgggattg gacaattgac ccaattgggc tgcgtatcgg tcttcgccga 352921 attacaagcc gctatcagct tccagtgttt ataacagaga acggtttggg tgaatttgat 352981 aaagttgagg acggcactgt acaggatgat tatcgaattg attatttgcg ttcgcatctt 353041 gagcaatgca gacaagccat cagtgacggt gtcgatttaa tcggctattg cagctggtcg 353101 tttactgatc tgttaagctg gctgaacggc taccaaaaaa gatacggatt tgtatatgtc 353161 aatcgtgatg aagaaagcac atccgattta aaacgcttga agaaaaaaag cttttattgg 353221 tatcaagatg tcatcaagac aaacggagaa agtttataaa gagtccctga gagttattct 353281 ctcaggggtt tttcattaca cagaaacagc atcaataata taagtgtcgg cgtgcaaatc 353341 tgacatttca gccggcacag tccagcatgt caattgatag tctcctttag gcagatcaaa 353401 ggacagtctt ttagacatga tgctttcaat atgaattccg ttttctgtga catgaaaagg 353461 aacagtcact tttttttcgt aggagtttac tgtttctgaa ctgttcaggc gaaaaagaat 353521 aaaggccttt gtatttcgct gtgcctcaaa ggaaatggct ccgtctgccg cagcatatcc 353581 tttttcaatc gcttcgtcag tccaatccat tacaggaggt gtagaatcct tttgaaatac 353641 agtaaattga tgatatgaaa tcgaaagttc ttgcggcttc catgatttga tcaatgtgct 353701 gttcctcctc tatgtactgt ttactgaatt gtgaataaaa cctttgtgcc gtctgggtaa 353761 tcggtaagcc gatgcccgac ccaagagcct gctccgcggt tgtcagcggg agaaatgtat 353821 tctacagaag ctccctcacc gccttctttg cacatggcca ttggccattc atctctgtca 353881 tacccctttt tggaaggtac gtcctttaat gattgctcgc ggcgttcttc agctccgtct 353941 ctgtcaatag tgcacacctc tgagtgcccc tcatttatcg catccttaat atgcttggca 354001 gtttcgggat accggtcaga tgggaaggcc attgtttcat catattcttt cgtttgagac 354061 gttttttgat cagctgagaa aaagtctcct tttatcaggc cgacagctgc agctgctatg 354121 atgacgatga cgagaagtat cgtttttatg atgtccgtcg tgatgttcac ctcccgcttt 354181 taaaactgac acaagagtaa tccagaaagc atttggtgta aaggtttaaa ttttatgttt 354241 tacgatcagt ttattgcaga aatcgtaatt ttagcagatc gaaatatttg ttttcagcaa 354301 aatacgattg ccaatttaca ataatgatag taagtcatca gccgttttcg gcttgattaa 354361 tcattttaaa ttggcttatg ataccggtaa gctcctcagc taattgagaa agtgtttcag 354421 aagctgcggt aatctcctcc attgcagcaa attgctcctc tgttaatgca gccgcttgcc 354481 gggtattttt agtagattct ttaatgtcgg ccgtattggc tgcaaaggaa tcatttattt 354541 gatgtgcact ggctgaaatg tttgttacag atgctgataa atcactaatc tcggcgctga 354601 tttcacctgt tgcagctgca atttccttaa atgcatctct ggtgcgctgg atcatggtga 354661 ctccttctgc agcttctgtt ttcacatgct caacagatct tgcagaccgg ttcatatcct 354721 tttgtatttc tatgatcagt tttgaaatct gccccgcaga ctgttgagac tcttctgcta 354781 atttccgtac ttcatcagca acaacagcaa agccttttcc ttgttcaccg gctctggcag 354841 cttcaatcgc tgcattcagc gcaagcaggt ttgtctgatc agcaatttgg gtgatgaccg 354901 ataaaatttg ctcaatttgt ttagagcggc cgtctaactg gtgtatgatt tctccgcttt 354961 tctgaattga ctggtgaatc gcatccattt gcgcctgtac atttgcaatt tccttttgtc 355021 caatgtctgc ttttgattga gcgagctgcc ctttgtcagc gatagcggca gtatttgcag 355081 aaatatcccg gatgtctgct gaagcttgtt ttaatgagct ttcactattt tcaattcggg 355141 tgatctgatc ttgggctcca tttgcaatct gctgtacagc ttctgtgatt ttttctgaag 355201 cttgatttgt ttcctctgct ccggctgaga gctgctgaga ggctgacgca agctgaaggg 355261 ctgattgttg tacggtttgt atggtatcgt tcagcttcat tctcatctta ttataataga 355321 cgcttagttc tgaaagctcg tcaccggttt tgtctgacac ctctattgtc atatctccgt 355381 ttccggcact ttcaaaggcg ctttttaaag cgttcagccg cttgttgatt tttctggtga 355441 aaaccaagac aaggatgact gataccataa tgacgataac aagaacgata gcgaattgag 355501 tgaaaagtga ttgtgtaagt gatgctaaaa tactttgatt agctccggta tacagcatgc 355561 cgatgatgtt cccattttga tcttttaacg gcatgtatgc agtctgataa gaagaacctg 355621 ctacatctgc ttgtccgtaa aaacgctttc ctttctttaa aacagcggca ataacttcag 355681 aagaagcctg ggtgccgacg gctctttcgc catttttcat gacattggtt gcaacacgag 355741 tatcgccttg gaaaatggta atggtatcac ctgtcttttc accaagcaga tcaacaatat 355801 cttcatttcc attgatttgt gtttgccctt tatagagctt attgtttttc acctgccagt 355861 cgcctgacat gacatcatca atataagtgc tgcttaaagc gagatcacct ttcgcttttt 355921 cagttgccat ttgtttcatg ctttctgtaa tttccttaag catcacagtg ccaactgatg 355981 ccgaaaacaa aagaatcacc acgaaaacga ggcaaagaat tttagttcct agcttcatct 356041 taaatcgttt tatcaacata attcctccct ttacgatttg caggtcatat tacttatcgg 356101 gtttttgggt ttaaagtttt attttagaaa aaataaaacc ggcctgatct tcaggccggt 356161 tgtgtgatgc tattcaaggt ttgcgtggtg agtgaacata gtttcagaat cgagaccttt 356221 tttctccatg agttttaaaa tcactgcatc atagaagagc agcaaagttt gttcaaataa 356281 tgatcccatt ggctgaatgg ttttatagct tccgttagac tggtctttag gggaaccagg 356341 cattctgatg atgaggtccg cttgttttcc gatgcttgat tccggattga tggttaaagc 356401 ggcaacaatt ccgtgtaagc tttttgcttt tgctgcggta tgaatcaagc tctttgtctc 356461 gcctgatcct gagccgataa taactagatc tccttcggcg agcggcggag tgagaatctc 356521 acctactata tgggcgttga agcccatgtg catcagtctc atcgcgaagg attttgccat 356581 caggccagac cgccccgcac ccgcggtgaa aatttggtgg gatgaaagaa tgtgatcggc 356641 aagctggtca gcttcttcat tagaaatata agctgctgaa ttgtgtaact cattgagaat 356701 ttccgctacg tattcagtcg ttttcatcgg agttatcctt ggacaatcag ctgcttcatt 356761 tttgaagctg tttccgcctt atcagctgcg cttgtaattc cgcccccgac aatgacaagg 356821 tcaggctttt gctggatcac ttctggcagt gtatcaagtt tgatgccgcc cgcgattgcg 356881 gtttttgcgt tttttacggt atttttgatt gtcgttaatt cttcgaaaga gtttttgccc 356941 tctgcttgaa gatcatagcc agtgtggacg cagatgtagt caacaccgag tgcgtcaatt 357001 tctttcgcac gggattcgat atctttcacg ttaatcatgt ccactaagat tttcttcttt 357061 tgttttttgg cttcttctac tgcgccttta atcgttgcat cgtctgtagc ccctaaaacg 357121 gtgatgatgt cagcgcctgc ttccgacgct ttcataattt cgtagcctcc ggcatccatg 357181 attttcaggt ctgcaagaac cttcaattga ggaaatgctt cttttatttc tttaacggct 357241 cttaggcctt cattgatgac gaccggtgtt ccgatttcaa ctacgtcgat gtattgttct 357301 acctctttga caagctcaat ggcttccggg atgttgacga ggtctaatgc aagctgtaat 357361 tccattgttg atccactccc tttttcgaat tattgttcat tctataggtt ccttcttttg 357421 ttgagaagta ggcactttga agtcaacaag ttacttggag gatactgtga ggagagacaa 357481 tcagatttct ttcgcttgat tttatgagtg agtataatga aaaaagagtc tgcaaaaaag 357541 taagtaagtg atgatacgta tctaacatac aaaaaggtta ctaagggggg ggattctatt 357601 gagccggatg gacgacaaaa ggtttaattg tgagaaggaa ttaacgcttg cagtgattgg 357661 cggtaaatgg aaaatgctca ttttatggca tttaggaaaa gaaggcacaa aacggttcaa 357721 tgaattaaaa acattgattc ctgatattac gcagaagatc ctcgtgaatc agctgagaga 357781 gcttgagcag gatatgattg ttcacaggga agtgtatcca gttgtcccgc cgaaggttga 357841 atattctctg accccgcacg gagaaagcct catgcctatt cttgaagcca tgtatgagtg 357901 ggggaaaggc tatatggaat tgattgatat cgacaaaaat gtcatgaaag aatcgttgta 357961 agacgctctt cgcaagggtg tctttttttg cctttttttc ggtttttgcg cggtacacat 358021 agtcatgtaa agattgtaaa ttgcattcag caataaaaaa agattgaacg cagcagtttg 358081 gtttaaaaat ttttattttt ctgtaaataa tgtttagtgg aaatgattgc ggcatcccgc 358141 aaaaaatatt gctgtaaata aactggaatc tttcggcatc ccgcatgaaa cttttcaccc 358201 atttttcggt gataaaaaca tttttttcat ttaaactgaa cggtagaaag ataaaaaata 358261 ttgaaaacaa tgaataaata gccaaaattg gtttcttatt agggtggggt cttgcggtct 358321 ttatccgctt atgttaaacg ccgcaatgct gactgacggc agcctgcttt aatagcggcc 358381 atctgttttt tgattggaag cactgctttt taagtgtagt actttgggct atttcggctg 358441 ttagttcata agaattaaaa gctgatatgg ataagaaaga gaaaatgcgt tgcacatgtt 358501 cactgcttat aaagattagg ggaggtatga caatatggaa ataacttttt accctttaac 358561 ggatgcacaa aaacgaattt ggtacacaga aaaattttat cctcacacga gcatttcaaa 358621 tcttgcgggg attggtaagc tggtttcagc tgatgcgatt gattatgtgc ttgttgagca 358681 ggcgattcaa gagtttattc gcagaaatga cgccatgcgc cttcggttgc ggctagatga 358741 aaacggggag cctgttcaat atattagcga gtatcggcct gttgatataa aacatactga 358801 cactactgaa gatccgaatg cgatagagtt tatttcacaa tggagccggg aggaaacgaa 358861 gaaacctttg ccgctatacg attgtgattt gttccgtttt tccttgttca ccataaagga 358921 aaatgaagtg tggttttacg caaatgttca tcacgtgatt tctgatggta tctccatgaa 358981 tattctcggg aatgcgatca tgcacattta tttagaatta gccagcggct cagagacaaa 359041 agaaggaatc tcgcattcat ttatcgatca tgttttatct gaacaggaat atgctcaatc 359101 gaagcggttt gaaaaggaca aggcgttttg gaacaaacaa tttgaatcgg tgcctgaact 359161 tgtttccttg aaacggaatg catccgcagg gggaagttta gatgctgaga ggttctctaa 359221 agatgtgcct gaagcgcttc atcagcagat tctgtcgttt tgtgaggcga ataaagtcag 359281 tgttctttcg gtatttcaat cgctgctcgc cgcctatttg tacagggtca gcggccagaa 359341 tgatgttgtg acgggaacat ttatgggcaa ccggacaaat gcgaaagaga agcagatgct 359401 tggcatgttt gtttctacgg ttccgcttcg gacaaacatt gacggcgggc aggcgttttc 359461 agaatttgtc aaagaccgga tgaaggatct gatgaagaca cttcgccacc aaaagtatcc 359521 gtataatctc ctaatcaacg atttgcgtga aacaaagagc tctctgacca agctgttcac 359581 ggtttctctt gaatatcaag tgatgcagtg gcagaaagaa gaggatcttg cctttttgac 359641 tgagccgatt ttcagcggca gcggattaaa tgatgtctca attcatgtaa aggatcgatg 359701 ggatactggg aaactcacca tagattttga ttaccgcact gatttatttt cacgtgaaga 359761 aatcaacatg atttgtgagc gcatgattac catgctggag aacgcgttaa cgcatccaga 359821 acatacaatt gatgaattaa cactgatttc tgatgcggag aaagagaagc tgcttgcgag 359881 ggccggcggt aaatctgtga gctaccgtaa ggacatgacg ataccagagc tgttccaaga 359941 aaaggctgaa ctgctttctg atcatccagc ggttgtattt gaagatcgca cattgtccta 360001 tcgaacgtta catgagcaat ctgcacgcat cgccaatgtg ctgaaacaga aaggggttgg 360061 cccggacagt cctgtcgcgg ttttgattga acgctctgaa cggatgatta cagctatcat 360121 gggaatttta aaagccggcg gagcctatgt gccgattgat ccgggttttc ctgctgagcg 360181 cattcaatat attttggagg actgcggggc ggatttcatc ctgactgaat cgaaggttgc 360241 ggcgcctgaa gccgatgctg agctgattga cttagatcag gcgattgagg aaggtgcaga 360301 agaaagcctg aatgcagatg tgaacgctcg gaaccttgcc tacattattt acacatcggg 360361 aacaaccgga cgcccgaaag gcgttatgat cgagcatcgc caggttcatc atttggttga 360421 atctctgcag cagacgattt atcaaagcgg cagccaaacc ctgcggatgg cattgcttgc 360481 gccgttccac tttgatgcgt cagtgaagca gatcttcgcg tcgcttcttt tgggccaaac 360541 cctttatatc gtaccgaaga aaacagtgac gaacggggcc gcccttactg catattatcg 360601 gaagaacagc attgaggcga cggacggaac accggctcat ttgcaaatgc tggcagcagc 360661 aggcgatttt gaaggcctaa aactgaagca catgctgatc ggaggagaag gcctgtcatc 360721 tgttgttgcg gacaagctgc tgaagctgtt taaagaagcc ggcacagcgc cgcgtttgac 360781 taatgtgtac gggccgactg aaacgtgcgt tgacgcgtct gttcatccgg ttatccctga 360841 gaatgcagtt caatcagcgt atgtgccgat cgggaaagcg ctggggaata accgcttata 360901 tattttggat caaaaaggcc ggctgcagcc tgaaggcgtg gcgggtgagc tttatatcgc 360961 gggagacggt gtgggccgag gctatttaca tttgcctgaa ttaacggaag agaagttttt 361021 acaagatcca ttcgtgccgg gcgatcgcat gtaccggacc ggggacgtgg tgcgctggct 361081 tccagatgga acaatcgaat atttaggcag agaggatgac caggtcaaag tccgcggata 361141 ccggattgag cttggggaaa ttgaagccgt gattcagcag gcgccagacg ttgcaaaagc 361201 cgttgttttg gcacgccctg acgaacaggg aaatcttgag gtttgcgcat atgttgtgca 361261 gaagcctgga agcgaatttg cgccagccgg tttgagggag catgcggcca gacagcttcc 361321 tgactatatg gtgccggctt actttacaga agtgacagaa attccgctta caccaagcgg 361381 caaagtcgac cgccgcaagc tgtttgcact agaggtgaag gctgtcagcg gcactgccta 361441 tacagcgccg cgaaatgaga ctgaaaaagc aatcgcagcc atttggcagg acgtgctgaa 361501 cgttgagaag gcggggatct ttgacaattt ctttgaaact ggcggacatt cattaaaagc 361561 catgaccctt ttaacaaaga ttcataagga aacaggcatt gagattccgc ttcaattttt 361621 gtttgagcat ccgacgatta cggctcttgc agaggaagct gatcacagag aaagcaaagc 361681 ttttgcggtg attgaacctg ctgaaaaaca ggagcattac ccgctttcat tggcacagca 361741 gcgaacatat atcgtcagcc agttcgagga tgcgggagtc ggctataaca tgccagcagc 361801 agcaattctg gaagggcctt tagatattca aaagctggag cgcgcatttc agggattaat 361861 ccgacgccac gagtcattga gaacatcatt tgttcttgaa aacagcacgc cgagacagaa 361921 aattcacgat agcgttgatt tcaacatcga aatgattgaa agaggcggcc gctcagatga 361981 ggcaattatg gcttcattcg ttcggacatt tgatttggcg aaagctccgc tgttcagaat 362041 cggtttgctg gggcttgaag agaaccgtca tatgctgctg tttgacatgc accatttgat 362101 ttctgacggt gtatccattg gcattatgct ggaggagtta gcacgcattt ataaaggcga 362161 acagcttcct gatcttcgtc tccagtataa ggactacgct gtatggcaaa gcagacaggc 362221 tgctgaaggg tacaagaagg accaggctta ttggaaggaa gtctttgcag gcgagctccc 362281 ggtgcttcag cttctgtccg attacccaag accacctgtt caaagctttg aaggggatcg 362341 ggtgtcaatc aagctggatg cgggggtaaa ggatcgcctc aatcgtttgg ctgaacaaaa 362401 cggcgccact ttatatatgg tgatgctttc cgcttactat acgcttttgt caaagtatac 362461 ggggcaggat gacatcattg tcgggacacc gtcagcgggc agaaatcact ccgatacaga 362521 gggcattatc gggatgttcg tcaatacgct tgcgattcgc agtgaggtga agcagaatga 362581 gacgtttacc caattgatct cgcgtgtccg caaacgggtg ctggatgcct tttctcatca 362641 ggactatccg tttgagtggc ttgttgaaga tttgaacatc ccgcgtgatg ttagcaggca 362701 tccgctgttt gacacgatgt tcagccttca aaacgcgaca gagggcattc cggctgtcgg 362761 cgatctttcc ttgtctgttc aagagaccaa tttcaagatt gccaaatttg atttgacggt 362821 gcaggcgaga gaaaccgatg aaggcattga gattgatgtg gattacagca caaagctgtt 362881 taaacaaagc acggcagaca ggctgcttac gcattttgcg cgtttgcttg aagatgctgc 362941 ggctgatcca gagaagccga tttctgagta taagcttctt tctgaagagg aggctgcttc 363001 gcaaattcag cagtttaacc cgggcagaac accttatccg aaagataaaa caattgttca 363061 gctgtttgag gagcaagcgg cgaatacgcc agaccacact gcgcttcaat atgaaggcga 363121 atcactcact tatcgtgaac tgaatgaacg ggccaatcgt ttagcccgcg gcattctttc 363181 tcttggagct ggcgaaggca gaactgcggc tgtcttatgc gagcggtcaa tggatatgat 363241 tgtgtcgatc ttggcagtat taaaatcagg ttcggcttat gttccgatcg atccggaaca 363301 tccgattcag cggatgcagc atttcttccg tgacagcgga gcaaaggtgc ttctcactca 363361 gaggaaatta aaggctttgg cggaagaagc ggaatttaag ggcgttatcg tgctagccga 363421 tgaggaagaa agctatcatg ccgatgcgcg aaatctcgca ctgcctcttg attctgcagc 363481 aatggccaac ctgacgtata cttccggaac gactggaaca cctaagggga atatcgtgac 363541 acatgccaat attctccgca cggtgaagga aacgaattat ctcagcatta cagaacagga 363601 tacgattctc ggtctttcca attacgtgtt tgacgcgttt atgttcgata tgttcggctc 363661 tttgttaaac ggagccaagc tggtgctgat accgaaggaa accgttttgg acatggctcg 363721 cctgtcccgc gtcattgaac gggagaacat cagcattctc atgattacaa ccgctttgtt 363781 ccacttgctt gtggacttga atccggcatg cttgtcaacg cttcgcaaga ttatgtttgg 363841 cggggaacgg gcttcggttg agcatgtcag aaaagctttg caaacggttg gaaagggcaa 363901 gctccttcat atgtatggac cgtctgaaag cacggttttc gcgacgtatc atccggttga 363961 tgaattggag gagcacacgc tgtctgttcc gattggaaaa ccggtcagca atacggaagt 364021 atacattctt gaccgtacgg gacacgtgca gcctgccggg attgccggag agctttgcgt 364081 cagcggcgaa ggactcgtga aaggctatta caaccgtcca gaactgactg aggagaaatt 364141 tgttccccat ccgtttacat ccggcgaacg catgtataaa acgggagacc ttgcgagatg 364201 gctgccgaat ggcgacatcg aatttatcgg gcgaatcgac catcaggtga agattcgcgg 364261 acagcgcatc gagcttggag aaatcgaaca tcagctgcaa acccatgatc gtgttcagga 364321 aagtgttgtg cttgccgttg atcaaggagc gggagataaa ctgttgtgtg cttactatgt 364381 cggagaagga gacatctcat cacaagagat gagagagcat gctgcgaagg acttgccggc 364441 atatatggtt cctgcggtgt ttatccaaat ggacgagctg ccgctgacag ggaacggaaa 364501 aattgaccgg agagcgctgc cgattcctga tgccaacgtt tcaagaggtg tttcatatgt 364561 tgcgccacgc aatggaacgg aacaaaaagt cgcggacatt tgggcacagg tacttcaggc 364621 agaacaagtc ggcgcttatg accacttctt tgacattggc ggacattcat tagcaggcat 364681 gaagatgctt gccttggttc atcaggaact gggcgttgag ctgtcactca aggatctctt 364741 ccagtcaccg acggttgagg gcttggcaca ggtgattgcc tctgctgaaa aagggacagc 364801 cgcaagtatc agcccggcag agaaacaaga tacgtatcct gtttcttcac cgcaaaaacg 364861 gatgtacgtg cttcagcagc ttgaggatgc gcaaacgagc tataacatgc cggcggttct 364921 gcgcctgaca ggtgagcttg atgttgaaag gcttaacagc gtcatgcagc agttaatgca 364981 gcgtcatgaa gccttgagaa ccacgtttga aataaaagat ggagaaacgg tgcagcggat 365041 ctgggaagag gctgagtgcg agatagccta tttcgaagcc ccggaagaag agacagagcg 365101 gatcgtttct gagtttatta agcctttcaa aatcgaccaa cttccactgt tcagaatagg 365161 gcttatcaag cattcagaca ctgagcatgt gctgctgttc gatatgcatc atattatttc 365221 tgatggtgca tctgtcggtg tgctgattga ggagctttca aagctgtacg acggagaaac 365281 ccttgagccg ctccgtattc aatataagga ttatgccgtg tggcagcagc agttcattca 365341 gtctgagctt tacaagaagc aagaagagca ttggctgaag gagctggacg gagagctgcc 365401 ggtgctgacg cttccgactg attacagtcg gcctgccgtt caaacatttg agggagaccg 365461 cattgcattt tcattagaag caggcaaagc tgatgctctg cgcaggcttg caaaagaaac 365521 ggattccacg ctttacatgg tgcttctggc ttcatacagt gcgtttttat caaaaattag 365581 cgggcaagac gatatcatcg tcggttcacc tgtggccgga cgatctcaag cggacgtcag 365641 ccgcgtcatc ggaatgttcg tcaatacatt ggcgctgcgc acgtatccga agggtgaaaa 365701 gacgtttgct gactatctta acgaagtgaa agaaacggca ctcagcgctt ttgatgcgca 365761 ggattaccca cttgaggatt tgatcggaaa tgttcaggtt cagcgtgaca caagcagaaa 365821 tccgttattc gatgcagttt tttcaatgca aaatgcgaat ataaaggatt taacaatgaa 365881 agggattcag cttgagccgc atccgtttga acggaaaaca gccaagtttg acctcacgct 365941 gacggctgac gaaaccgacg gagggcttac attcgtactc gaatacaata cagctctgtt 366001 taagcaggaa acgattgaac gatggaagca atattggatg gagcttttag atgcagttac 366061 tgggaacccg aaccagccgc tttccagcct gtcactggtc accgagacag aaaagcaagc 366121 gcttcttgag gcatggaagg gcaaagcgct gcctgtgccg acagacaaaa cggttcatca 366181 gctattcgaa gagactgccc agcgccacaa agaccgcccg gctgtcacat acaacggcca 366241 gtcttggacg tacggcgagc tgaatgcgaa ggcaaaccgt ctcgcgcgga ttctgatgga 366301 ctgcggcatc agcccggatg accgcgtcgg cgttctcacg aagccgtcgc ttgaaatgtc 366361 cgccgcggtg ctcggcgtct tgaaagccgg agcggcgttt gtgccgattg atcctgacta 366421 tccggatcag cggattgagt atattttaca ggacagcggc gcgaagcttc tcttgaaaca 366481 ggaaggcatt tcagtgccgg acagctatac gggagatgtc attcttctcg acggaagccg 366541 cacgattcta agcctgccgc ttgatgaaaa cgacgaggaa aatccagaaa ccgctgtaac 366601 cgcggagaac ttggcgtaca tgatttacac gtctggaacg accggacagc cgaagggtgt 366661 catggtcgag caccatgcgc ttgtgaacct gtgcttctgg caccacgacg cgttcagcat 366721 gacagcggag gaccgcagtg cgaagtacgc gggctttggg ttcgacgctt ccatttggga 366781 gatgttcccg acctggacga tcggtgccga acttcacgtc attgaggaag cgatccgcct 366841 cgatatcgtc cgcctgaacg attattttga aacgaacggc gtaacgatca cgttcctgcc 366901 gacacagctt gcggaacagt tcatggagct tgagaacaca tcacttcgcg tattgcttac 366961 tggaggagac aagctgaagc gcgcagtgaa aaagccgtac acactcgtca ataactacgg 367021 gccgacagag aatacggtcg ttgccacaag cgcagaaatc catccggagg aaggctcgct 367081 ttccatcgga agggccattg ccaatacgag agtatacatt ctcggcgagg gcaatcaggt 367141 gcagccggaa ggcgtagccg gagagctttg cgtggcgggg cgcggactgg cacgcggcta 367201 tctgaatcga gaagacgaaa ccgcgaagcg gtttgtcgct gatccgtttg tgccgggtga 367261 gcgcatgtac cgcaccggcg atttggtgaa atggacgggc ggcggcatcg aatacatcgg 367321 ccggatcgac cagcaggtca aggtccgcgg ctaccggatc gagctctcag aaattgaagt 367381 ccagctcgcc cagctttctg aggtgcagga tgcggcggtg acagctgtca aagataaagg 367441 cggcaacaca gcgatcgcgg cgtatgtcac accggaatca gctgacatag aagcactgaa 367501 atcagcactg aaggaaaccc tgccggatta catgatcccg gcgttctggg tgacgctgaa 367561 cgagcttccg gttacggcaa acggcaaagt ggaccgcaaa gccttgcctg agccggacat 367621 cgaagcggga agcggagaat acaaagcgcc gacgaccgac atggaagagc tgcttgccgg 367681 catctggcag gacgtgcttg gaatgtctga agtcggtgtc accgacaatt tcttctcgct 367741 tggcggagat tccatcaaag gaattcaaat ggcgagccgc ttgaaccagc acggctggaa 367801 gctggaaatg aaagatctct tccagcaccc gacgatcgaa gagctcaccc agtacgtaga 367861 gcgtgccgaa ggcaaacagg cagaccaagg cccggtggag ggcgaagtca tcctgacgcc 367921 gatccagcgc tggttctttg aaaagaactt cacgaacaag caccactgga accaatctgt 367981 gatgcttcac gccaagaagg gctttgatcc tgaacgggtg gagaaaacat tgcaggcgct 368041 gatcgagcat catgacgcgc tccgcatggt ctatcgtgag ggacaggaag acgtcattca 368101 atacaacaga ggtcttgaag ctgcttcagc tcaattggag gtcatccaga ttgagggcca 368161 agctgcagat tacgaagacc gaatagagag agaagcggag cgtttgcaaa gcagcatcga 368221 cttgcaggaa ggcggcttgt taaaagcagg cttgttccaa gcggaagacg gagatcactt 368281 gcttcttgcc attcaccact tagtggttga cggcgtgtcg tggcggattt tactggagga 368341 tttcgccgcg gtatatacac agcttgagca aggcaatgaa ccggttctcc cgcagaaaac 368401 acattcattt gcagagtatg cagagagatt gcaagacttc gcgaactcca aagccttttt 368461 gaaagaaaaa gagtattgga gacagcttga agaacaagct gttgcggcaa agcttccgaa 368521 agaccgcgaa tctggtgatc agcgaatgaa acatacaaag acaattgaat tctcgctgac 368581 tgctgaagag acagaacagc tcaccacaaa ggtgcatgag gcatatcaca cagaaatgaa 368641 tgatattttg ctgacggcat tcggattggc aatgaaggag tggacgggtc aagatcgagt 368701 aagtgttcat ttagaggggc atggacgtga agaaatcata gaagacctga ccatttctcg 368761 cacagtcggc tggtttacaa gtatgtaccc aatggtgctc gatatgaagc atgcggatga 368821 tctgggctac cagctgaagc aaatgaaaga agatatcaga catgtgccga ataagggagt 368881 cggatacggc attctgcgct atctgacggc accggaacat aaagaagatg tggcgttctc 368941 gattcagccg gatgtcagct tcaactattt aggtcagttt gacgaaatgt cggatgcagg 369001 tttgtttacg agatcagagc tgccatcagg acagtcatta agccctgaaa cagaaaaacc 369061 gaatgcgctg gatgttgtcg gatatatcga aaacggaaaa ctgacgatgt cactggccta 369121 tcattctctt gaatttcatg aaaaaacagt acaaacattc agtgacagct ttaaagcgca 369181 tcttctcaga atcattgaac attgcctatc tcaagatggt acggaactga ccccgagtga 369241 tcttggtgac gacgatttga cgctggatga gctggataaa ttaatggaaa ttttctaata 369301 gaggtggcat atgagcaaaa aatcgattca aaaggtgtac gcactgacac caatgcagga 369361 gggaatgctg tatcatgcga tgcttgatcc gcattcttcc tcgtacttca cacaattaga 369421 gcttgggatt cacggcgctt ttgatcttga aatctttgag aaaagcgtca atgaactgat 369481 tcggtcatac gatattctcc gtacggtatt tgtgcatcag cagctgcaaa aaccgcgtca 369541 ggtcgtgtta gcggaacgca aaacaaaagt gcattatgag gatatcagtc atgcagacga 369601 aaaccgccag aaagagcaca ttgagcgtta caaacaagac gttcagcgcc aaggctttaa 369661 cctggcaaaa gacatattgt tcaaggtagc ggttttccgc cttgctgcag atcagctgta 369721 tcttgtctgg agcaatcatc atattatgat ggacggctgg agcatgggcg tcctcatgaa 369781 aagcctgttc caaaactatg aagcgctcag agcaggcagg acaccggcaa acggtcaggg 369841 caagccttat tccgattaca tcaagtggct tggaaaacag gacaatgaag aagcggagag 369901 ctactggagc gagcgcttgg cgggttttga acagccaagc gtgctcccgg gccgcctgcc 369961 tgtgaaaaaa gacgaatacg tcaataaaga atattcattt acatgggacg aaacactggt 370021 tgcccgtatt cagcaaaccg caaatctcca tcaagtgaca gggcctaacc tatttcaggc 370081 cgtttggggc attgttctca gcaaatacaa ctttacggat gatgtgatct tcggaacggt 370141 cgtctcggga cgaccgtctg aaatcaacgg aatcgaaacg atggcggggc tgtttatcaa 370201 caccattcca gtgcgggtga aagttgaacg agatgctgca ttcgctgata ttttcacagc 370261 tgttcagcag catgcagtag aggcagagcg ttacgattac gtgccgctct atgagattca 370321 aaaacgctca gctcttgatg gcaatctctt aaaccatctg gtcgcgtttg aaaattatcc 370381 gcttgatcaa gagcttgaaa acggcagcat ggaagaccgc ctcgggtttt cgattaaggt 370441 agaaagcgca tttgaacaaa cgagcttcga tttcaacctg attgtgtatc cgggcaaaac 370501 gtggaccgtc aaaattaaat ataacggagc cgcctttgat tccgctttta tcgaacggac 370561 agcggagcac cttacccgca tgatggaagc agctgtcgat cagccggccg cttttgtgcg 370621 tgagtacggg cttgtgggag acgaagagca gcggcaaatt gtcgaggtgt ttaacagcac 370681 gaaagccgaa ctccctgaag gaatggctgt tcaccaagtg tttgaagagc aagcgaaacg 370741 gacgccggcg agcaccgccg tcgtatatga aggaaccaag ctgacgtacc gcgagctgaa 370801 tgcagcggct aaccgtctgg cgagaaagct tgtcgaacat gggcttcaaa aaggggaaac 370861 agcagcgatt atgaacgacc gctcagtaga aaccgttgtc ggcatgctgg ctgttttaaa 370921 agcaggcgcc gcatatgtgc cgcttgatcc agcgcttcct ggggatcgtc ttcgtttcat 370981 ggcagaggac agctccgttc gaatggtttt gatcggaaat tcttatacag ggcaggcaca 371041 tcagctgcaa gtgccggttc ttacactgga cataggcttt gaagagagtg aagcggctga 371101 caatctcaac ctgccatccg ccccgtctga tttggcgtac atcatgtaca catccggttc 371161 aacgggcaaa ccgaaaggcg tcatgatcga acataaaagc attctgcgcc tcgtcaaaaa 371221 tgccgggtac gttcctgtta ctgaagaaga ccgcatggcg caaacgggag ctgtcagctt 371281 tgatgccgga acgtttgagg tattcggcgc actgctgaat ggcgcagcac tttatccggt 371341 caaaaaagag acactgcttg atgcgaaaca atttgctgca ttcctgcgtg agcaaagcat 371401 cacaactatg tggctgacat cacctttatt caaccagctt gctgcaaagg atgcgggtat 371461 gttcggcaca ctgcgccatt taatcatcgg cggagatgcc cttgtcccgc atattgtcag 371521 caaagtaaaa caggcatcgc cgtcgctttc attgtggaac ggatacggcc cgacagaaaa 371581 cacgacgttt tcaaccagtt ttctgatcga ccgcgagtat ggcggctcta tcccaatcgg 371641 gaagccgatc ggaaattcca ctgcctatat tatggatgag cagcaatgcc tgcagccaat 371701 cggcgcgcct ggtgagcttt gcgtaggcgg aatcggtgta gcgcgtgggt atgtcaatct 371761 ccctgagctg acggagaagc aatttctgga agacccgttc agaccgggtg agagaattta 371821 ccgcactggt gacttggcaa gatggctgcc ggacggcaat atcgaatttt taggcagaat 371881 cgacaaccaa gtgaaggtgc gcggcttccg aattgagctt ggcgaaattg aaacaaaact 371941 gaacatggct gagcatgtga cagaagccgc ggtgatcata cgcaagaaca aagcagacga 372001 aaatgaaatt tgcgcgtact tcacggcgga tcgtgaagtg gctgtgagtg agctgagaaa 372061 aacactgtct cagtctttgc ctgactatat ggtccctgcc cacctgattc aaatggacag 372121 cctgccgctc acgccaaacg ggaaaatcaa caaaaaggaa ctgcctgcac cgcaatcaga 372181 agccgtgcag ccggaatacg cagcaccaaa aacagagagt gaaaagaaat tagcggagat 372241 ctgggaagga atactcggcg tcaaagcagg cgttaccgat aacttcttta tgatcggcgg 372301 ccattctttg aaagcgatga tgatgacggc gaaaattcaa gagcattttc ataaggaagt 372361 tccgataaaa gtgctttttg aaaagccgac tattcaagaa ctggcactgt atttggaaga 372421 gaacgaaagc aaggaggagc agacgtttga accgatcagg caagcatctt atcagcagca 372481 ttatcctgta tccccggccc agcggagaat gtatatcctc aatcagcttg gacaagcaaa 372541 cacaagctac aacgtccccg ctgtacttct gctggaggga gaagtagata aagaccggct 372601 tgaaaacgcg attcagcaat taatcaaccg gcacgaaatc ctccgtacat cgtttgacat 372661 gatcgacgga gaggttgtgc aaaccgttca taaaaacata tcgttccagc tggaggctgc 372721 caagggacgg gaagaagacg cggaagagat aatcaaagca tttgttcagc cgtttgaatt 372781 aaaccgcgcg ccgctcgtcc gttcgaagct tgtccagctg gaagaaaaac gccacctgct 372841 gctcattgat atgcatcata ttattactga cggaagttca acaggcattc taatcggtga 372901 tcttgccaaa atatatcaag gcgcagatct ggaactgcca caaattcact ataaagatta 372961 cgcagtttgg cacaaagaac aaactaatta tcaaaaagat gaggaatact ggctcgatgt 373021 ctttaaaggc gaactgccaa tactggatct tcccgcggat ttcgagcggc cagctgaacg 373081 gagctttgcg ggagagcgcg tgatgtttgg gcttgataag caaatcacgg ctcaaatcaa 373141 atcgctcatg gcagaaacag atacgacaat gtacatgttt ttgctggcgg cgttcaatgt 373201 actcctttcc aagtacgcgt cacaggatga tatcattgtc ggctcgccga cagctggcag 373261 aacacatcct gatctgcaag gtgtgccggg tatgtttgtc aacacggtgg cactcagaac 373321 ggcaccagcg ggagataaaa ccttcgcgca attccttgaa gaggtcaaaa cagccagcct 373381 tcaagcattc gagcaccaga gctatccgct tgaggagctg attgaaaagc ttccgcttac 373441 aagggataca agcagaagtc cgctgttcag cgtgatgttc aacatgcaga atatggagat 373501 tccttcatta agattaggag atttgaagat ttcctcgtat tccatgcttc atcatgttgc 373561 gaaatttgat ctttccttgg aagcggtcga gcgtgaagag gatatcggcc taagctttga 373621 ctatgcgact gccttgttta aggacgagac gatccgccgc tggagccgcc actttgtcaa 373681 tatcatcaaa gcggccgcgg ctaatccgaa cgttcggctg tctgatgtag atctgctttc 373741 atctgcagaa acggctgctt tgctagaaga aagacatatg actcaaatta ccgaagcaac 373801 ctttgcagca ctttttgaaa aacaggccca gcaaacacct gaccattctg cggtgaaggc 373861 tggcggaaat ctgttgacct atcgcgagct tgatgaacag gcgaaccagc tggcgcatca 373921 tcttcgtgcc caaggggcag gaaatgaaga catcgtcgcg attgttatgg accggtcagc 373981 tgaagtcatg gtatccattc tcggtgtcat gaaggcgggg gcagctttcc ttccgattga 374041 tcctgataca cctgaagaac gaatccgtta ttcattagag gacagcggag caaaatttgc 374101 ggtcgtgaat gaaagaaaca tgacggctat tgggcaatat gaagggataa ttgtcagcct 374161 tgatgacggt aaatggagaa atgaaagcaa ggagcgccca tcatccattt ccgggtctcg 374221 caatcttgca tacgtcattt atacgtccgg tacgaccgga aagccaaagg gcgtgcagat 374281 tgagcatcgt aatctgacaa actatgtctc ttggtttagt gaagaggcgg gcctgacgga 374341 aaatgataag actgtattgc tttcatctta cgcatttgac cttggctata cgagcatgtt 374401 ccctgtactt ctgggcgggg gcgagctcca tatcgtccag aaggaaacct atacggcgcc 374461 ggatgaaata gcgcactata tcaaggagca tgggatcact tatatcaagc tgacaccgtc 374521 tctgttccat acaatagtga acaccgccag ttttgcaaaa gatgcgaact ttgaatcctt 374581 gcgcttgatc gtcttgggag gagaaaaaat catcccgact gatgttatcg ccttccgtaa 374641 gatgtatgga cataccgaat ttatcaatca ctacggcccg acagaagcaa cgatcggcgc 374701 catcgccggg cgggttgatc tgtatgagcc ggatgcattt gcgaaacgcc cgacaatcgg 374761 acgcccgatt gcgaatgccg gtgcgcttgt cttaaatgaa gcattgaagc ttgtgccgcc 374821 tggagcgagc ggacagctct atatcacggg acaggggctc gcgagagggt atctcaacag 374881 gcctcagctg acagccgaga gatttgtaga aaatccatat tcgccgggaa gcctcatgta 374941 caaaaccgga gatgtcgtac gaagactttc tgacggtacg cttgcattta tcggccgggc 375001 tgatgatcag gtgaaaatcc gaggctaccg cattgagccg aaagaaattg aaacggtcat 375061 gctcagcctc agcggaattc aagaagcggt tgtactagcg gtttccgagg gcggtcttca 375121 agagctttgc gcgtattata cgtcggatca agatattgaa aaagcagagc tccggtacca 375181 gctttcccta acactgccgt ctcatatgat tcctgctttc tttgtgcagg ttgacgcgat 375241 tccgctgacg gcaaacggaa aaaccgacag aaacgctctg ccgaagccta acgcggcaca 375301 atccggaggc aaggccttgg ccgcaccgga gacagcgctt gaagaaagtt tatgccgcat 375361 ttggcagaaa acgcttggca tagaagccat cggcattgat gacaattttt tcgatttagg 375421 cggccattca ttaaaaggga tgatgctgat tgccaacatt caggcggaat tggagaaaag 375481 cgtaccgctt aaagcactgt tcgagcagcc gacagttcgc cagctggcgg cttatatgga 375541 ggcgtctgct gtttcaggcg gccatcaagt actcaaaccg gctgacaagc aggatatgta 375601 tccattgtca tccgcacaga aacgaatgta cgtgctcaat cagcttgacc gccagacgat 375661 aagctacaac atgccatctg ttcttctaat ggaaggagag cttgatattt cgcgcctgcg 375721 cgactcactc aatcagcttg tgaaccgtca cgaatcattg cggacgtcat ttatggaagc 375781 taatggtgag cctgttcagc gcatcattga gaaggcggag gttgatcttc atgtgtttga 375841 agccaaagaa gacgaagcgg accaaaagat taaggaattt atccggccat tcgacttaaa 375901 cgacgcaccg ctcattcgcg cagctttgct tcgaatagaa gcgaaaaaac atttgctgct 375961 tttagatatg catcatatca tcgcagacgg cgtctcaaga ggcatctttg taaaagaatt 376021 ggcgctgctt tacaaaggag agcagcttcc ggagccgacg cttcattata aagatttcgc 376081 cgtttggcaa aatgaagctg agcaaaaaga acggatgaag gagcatgagg cgtactggat 376141 gtcagttctt tcaggcgagc tgccagagct tgatctcccg ctcgattatg cccgtccgcc 376201 tgtgcaaagc tttaaaggag atacgatccg tttccgtacg ggaagtgaga cggcaaaggc 376261 ggtagaaaaa ctgcttgccg aaaccggaac gaccttgcac atggtgctcc atgctgtttt 376321 ccacgtcttt ttaagcaaaa tttccggaca gcgggatatc gtcatcggct ccgttactgc 376381 cggccggacg aatgctgatg ttcaggacat gccgggaatg ttcgtcaata cacttgccct 376441 gagaatggaa gcgaaagaac agcaaacatt tgcggagctt ttggagctag caaagcagac 376501 gaacctgtca gcccttgagc atcaggagta tccgtttgaa gatctggtta atcagcttga 376561 tctccctcgg gatatgagcc gaaacccatt gtttaatgtg atggtgacga cagaaaaccc 376621 tgataaagaa cagcttacat tgcaaaatct gagcatttca ccttatgagg ctcatcaggg 376681 aacttctaag tttgatctga cactgggcgg atttactgat gaaaatggca ttggcttgca 376741 gctcgaatat gcgacagatc tgttcgcaaa agaaacagct gaaaaatgga gcgaatacgt 376801 tctgcggcta ctaaaggctg ttgcggataa cccgaaccag ccgctttcca gtctgttact 376861 ggtcaccgag acagaaaagc aagcgcttct tgaggcatgg aagggcaaag cgctgcctgt 376921 gccgacagac aaaacggttc atcagctatt cgaagagact gtccagcgcc acaaagaccg 376981 cccggctgtc acatacaacg gccaatcttg gacgtacggc gagctgaacg cgaaggcaaa 377041 ccgcctcgcc cggattctga tggactgcgg catcagcccg gatgaccgcg tcggcgttct 377101 cacgaagccg tcgcttgaaa tgtccgccgc ggtgctcggc gtcttgaaag ccggagcggc 377161 gtttgtgccg attgatcctg actacccgga tcagcggatt gagtatattt tacaggacag 377221 cggcgcgaag cttctcttga aacaggaagg catttcagtg ccggacagct atacgggaga 377281 tgtcattctt ctcgacggaa gccgcacgat tctaagcctg ccgcttgatg aaaacgacga 377341 gggaaatcca gaaaccgctg taaccgcgga gaacttggcg tacatgattt acacgtctgg 377401 aacgaccgga cagccgaagg gtgtcatggt cgagcaccat gcgcttgtga acctgtgctt 377461 ctggcaccac gacgcgttca gcatgacagc ggaggaccgc agtgcgaagt acgcgggctt 377521 cgggttcgac gcttccattt gggagatgtt cccgacctgg acgatcggcg ctgaacttca 377581 cgtcattgat gaagcgatcc gcctcgatat cgtccgcctg aacgattatt ttgaaacgaa 377641 cggcgtaacg atcacgttcc tgccgacaca gcttgcggaa cagttcatgg agcttgagaa 377701 cacatcactt cgcgtcctct tgaccggagg agacaagctg aagcgggcag tgaaaaagcc 377761 gtacacactc gtcaacaact acgggccgac agaaaatacg gtcgttgcca caagcgcaga 377821 aatccatccg gaggaaggct cgctttccat cggacgggcc attgccaata cgagagtata 377881 cattctcggc gagggcaatc aggtgcagcc ggaaggcgta gccggagagc tttgcgtggc 377941 ggggcgcgga ctggcacgag gctatctgaa tcgagaagac gaaaccgcga agcggtttgt 378001 cgctgatccg tttgtgccgg gtgaacgcat gtaccgcacc ggcgacttgg tgaagtgggt 378061 gaacggcggc atcgaataca tcggccggat cgaccagcag gtcaaggtcc gcggctaccg 378121 gatcgagctc tcagaaattg aagtccagct cgcccagctt tctgaggtgc aggatgcggc 378181 ggtgacagct gtcaaagata aaggcggcaa tacagcgatc gcggcgtatg tcacaccgga 378241 aacagctgac atagaagcac taaaatcaac actaaaggaa accctgccgg attacatgat 378301 cccggcgttc tgggtgacgc tgaacgagct tccggttacg gcaaacggca aagtcgaccg 378361 caaagccttg cctgagccgg acatcgaagc gggaagcgga gaatacaaag cgccgacgac 378421 cgacatggaa gagctgcttg ccggcatctg gcaggacgtg cttggaatgt ctgaagtcgg 378481 tgtcaccgac aatttcttct cgcttggcgg agattccatc aaaggaattc aaatggcgag 378541 ccgcttgaat cagcacggct ggaagctgga aatgaaagat ctcttccagc atccgacgat 378601 cgaagagctc acccagtacg tagagcgtgc cgaaggcaaa caggcagacc aaggcccggt 378661 ggagggcgaa gtcatcctga cgccgatcca gcgctggttc tttgaaaaga acttcacgaa 378721 caagcaccac tggaaccaat cggtgatgct tcacgccaaa aagggctttg atcctgaacg 378781 ggtggagaaa acattgcagg cgctgatcga gcatcatgac gcgctccgca tggtctaccg 378841 cgaggaaaac ggggacatcg ttcaggtgta taaaccgatc ggtgagagca aggtcagctt 378901 cgaaatcgtg gatctgtacg gctccgatga agagatgctg agaagccaga ttaagcttct 378961 cgcgaacaag ctgcaaagca gtctcgatct gcgaaacggg ccgcttttaa aggcggagca 379021 atatcgcaca gaagctgggg atcacctgct cattgctgta caccatctcg tggtcgacgg 379081 tgtgtcatgg cggattttgc ttgaagactt tgcttcaggc tacatgcagg ctgagaaaga 379141 agagagcctt gtcttcccgc aaaaaacaaa ctccttcaag gattgggcgg aagaactggc 379201 ggcattcagc caatcagcgc atcttttaca gcaggctgaa tactggtcgc aaattgccgc 379261 tgaacaggtt tctcctttac ctaaggattg tgaaacagag cagcggatcg tcaaggatac 379321 atcatctgtc ctatgtgaat taacggcaga agacactaag catcttttaa cagatgttca 379381 tcagccatat ggaactgaaa tcaacgatat tcttctcagc gcgctcggtt tgacaatgaa 379441 agaatggaca aagggggcca aaattggcat taaccttgag ggacacggcc gggaggacat 379501 tatcccgaat gtgaatatct ccagaacggt cggctggttt acggcacaat accctgttgt 379561 gctcgacata tctgacgcag atgcctcagc tgtgatcaaa acagtcaaag aaaacctgcg 379621 ccgcattccg gacaaaggtg ttggctacgg cattcttcgt tatttcacag aaacagcgga 379681 aacaaagggc ttcacaccgg agatcagctt caactatttg ggccaattcg acagtgaagt 379741 caaaaccgat ttctttgaac cgtccgcttt cgatatgggg cgccaagtaa gcggagaatc 379801 agaggcgctg tacgcattaa gcttcagcgg catgatcaga aacggccggt ttgtgctttc 379861 ctgctcctac aatgagaagg agtttgaaag agctacagtc gaggagcaaa tggaacggtt 379921 taaagaaaac ctcctgatgc taatccgcca ttgcacggaa aaagaagaca aggaattcac 379981 accaagcgac ttcagcgccg aagaccttga aatggacgag atgggagata tctttgacat 380041 gcttgaggag aatttaaaat aaaacgcaag ggaattacag aaggcgggag cgaaacatat 380101 gagtcaattt agcaaggatc aggttcaaga tatgtattac ctatcgccga tgcaggaagg 380161 gatgcttttt catgccatcc tgaatcccgg ccaaagcttt taccttgaac aaatcacgat 380221 gaaagtaaaa ggcagcttga atatcaaatg tcttgaagaa agcatgaatg tgatcatgga 380281 ccggtacgat gtatttcgta ccgtgttcat tcacgaaaaa gtaaaaaggc ctgtccaagt 380341 cgtattgaaa aaacggcagt tccatataga agaaatcgat ctgacacact taacgggcag 380401 cgagcaaaca gccaaaatca atgagtacaa agaacaggat aagatcaggg gttttgattt 380461 gacgcgggat attccgatgc gggcagccat tttcaagaaa gctgaagaaa gctttgaatg 380521 ggtgtggagc taccaccaca ttattttgga cggatggtgc ttcggcatcg tcgtacagga 380581 tctatttaag gtatacaatg ctctgcgcga acaaaagccg tacagcctgc cgcccgtcaa 380641 accgtataaa gactacatca agtggcttga aaagcaggat aaacaagcat cactgcgtta 380701 ctggcgcgaa tatttagagg gctttgaagg acaaacgacg tttgcggagc aaagaaagaa 380761 acaaaaggac ggctatgagc cgaaagagct gctcttttca ctgtcggagg cggaaacaaa 380821 ggcctttacc gagcttgcaa aatcgcagca taccactttg agtacggcgc tgcaggcagt 380881 ctggagcgta ttgatcagcc gctatcagca gtctggcgat ttggccttcg gtacagttgt 380941 ttcagggcgt cccgcggaaa tcaaaggcgt tgaacatatg gtcgggctgt ttatcaacgt 381001 tgtcccgaga cgtgtgaagc tgtctgaggg tatcacattt aacggcttgc tcaagcggct 381061 gcaggagcaa tcgctgcagt ccgagccgca tcaatatgtg ccgctttatg acatccaaag 381121 ccaggccgat cagccgaaac tgattgacca catcattgtt tttgagaact atccgcttca 381181 ggatgcgaaa aatgaagaaa gcagtgaaaa cggctttgat atggtggatg ttcatgtttt 381241 tgagaagtcg aattatgatc tcaacctgat ggcttccccg ggagatgaga tgctgattaa 381301 gcttgcctat aatgagaatg tgtttgatga ggcgtttatc ctgcgcttga aatctcagct 381361 tcttacagca attcagcagc tcatccagaa tcctgatcag cctgtcagca cgatcaacct 381421 cgttgacgac agggagagag aatttttgct aaccggctta aacccgccgg ctcaagctca 381481 tgaaacaaag cctctgacgt attggttcaa ggaagcagtg aacgccaatc cggatgcacc 381541 ggcgcttacg tattccggcc agaccctgtc ttatcgcgaa ttagatgagg aagcgaaccg 381601 cattgcacgc cggctgcaaa aacacggtgc gggcaaaggc tctgttgtag cgctgtacac 381661 gaagcgctca cttgaactgg tgatcggcat tctcggtgta ttaaaggcgg gagcagccta 381721 tctgccggtt gatccgaagc tgccagagga ccgaatctcg tatatgctgg ctgacagtgc 381781 ggcagcctgt cttctgacgc atcaggagat gaaagaacaa gcggctgagc tgccgtatac 381841 aggcacaacg ctcttcattg atgatcaaac acggtttgaa gaacaggcaa gcgatcctgc 381901 aaccgcgatt gatcctaatg atccggcata tatcatgtac acgtccggca caaccggaaa 381961 gccaaagggc aatatcacca ctcatgccaa tattcaagga ttggtcaagc atgtagacta 382021 catggcattt tctgatcagg atacgttctt gtctgtttcg aattacgcct ttgatgcatt 382081 tacctttgat ttctatgctt ctatgctgaa tgcggcacgg ctcattatcg cagatgaaca 382141 tacgctgctt gatacagaac ggctcacaga tctgatcctg caagagaatg tcaatgtcat 382201 gtttgcgaca accgcactat ttaatcttct cacagatgcg ggagaggatt ggatgaaggg 382261 gcttcgctgt atattattcg gcggagagcg cgcgtcagtg cctcatgtca gaaaagcgct 382321 gcggatcatg gggccgggca agctgattaa ctgctacggg ccgactgagg gaacagtgtt 382381 tgcgacagct cacgtcgtgc atgatctgcc ggattccatc tcctcattgc cgatcggaaa 382441 gccgatcagc aatgccagtg tttatattct gaatgagcaa agccagctcc agccattcgg 382501 ggcggtcggt gaactgtgca tcagcggaat gggcgtgtca aaagggtatg taaatcgtgc 382561 tgacctcacg aaggaaaagt ttatcgagaa cccgttcaag ccgggagaaa cgctttaccg 382621 tacaggggat ttagcgcgct ggctgccgga tggaacgatt gaatacgccg gccgtattga 382681 cgaccaggtc aaaatacgcg gacaccggat tgagcttgaa gaaatcgaaa agcagctgca 382741 ggaataccca ggtgtgaaag atgcggtcgt tgtggcggac cgccatgagt ctggcgatgc 382801 atcaatcaat gcctaccttg tgaaccgaac gcagctttca gctgaagacg tgaaggcgca 382861 cctgaaaaaa cagcttcctg cttacatggt gccgcaaacc tttaccttct tggatgagct 382921 tcctttaacg acgaacggga aagtcaataa acggctgctc ccaaaacctg atcaggatca 382981 gctggcggaa gaatggattg gaccgcggaa cgagatggaa gaaacaatcg cacaaatatg 383041 gtctgaggtt ctcggcagaa agcaaattgg cattcatgac gatttctttg cgctcggagg 383101 gcattccttg aaggccatga ccgccgcgtc ccgcatcaag aaagagctcg ggattgatct 383161 tccagtgaag cttttgtttg aagcgccgac gatcgccggc atttcagcgt atttgaaaaa 383221 cgggggctct gatggcttgc aggatgtaac gataatgaat caggatcagg agcagatcat 383281 tttcgcattt ccgccggttc tgggctatgg ccttatgtac caaaatctgt ccagccgctt 383341 gccgtcatac aagctatgcg cctttgattt tattgaggag gaagaccggc ttgaccgcta 383401 tgcggatttg atccagaagc tgcagccgga agggccttta acattgtttg gatattcagc 383461 gggatgcagc ctggcgtttg aagctgcgaa aaagcttgag gaacaaggcc gtattgttca 383521 gcggatcatc atggtggatt cctataaaaa acaaggtgtc agtgatctgg acggacgcac 383581 ggttgaaagt gatgtcgaag cgttgatgaa tgtcaatcgg gacaatgaag cgctcaacag 383641 cgaagccgtc aaacacggcc tcaagcaaaa aacacatgcc ttttactcat actacgtcaa 383701 cctgatcagc acaggccagg tgaaagcaga tattgatctg ttgacttccg gcgctgattt 383761 tgacatgccg gaatggcttg catcatggga agaagctaca acaggtgttt accgtgtgaa 383821 aagaggcttc ggaacacacg cagaaatgct gcagggcgaa acgctagata ggaatgcgga 383881 gattttgctc gaatttctta atacacaaac cgtaacggtt tcataaatga agtgatgaaa 383941 ggaggagaca gccaatgagc caactcttca aatcatttga tgcgtcggaa aaaacacagc 384001 tcatctgttt tccgtttgcc ggcggctatt cggcgtcgtt tcgccctctc catgcttttt 384061 tgcaggggga gtgcgagatg ctcgctgccg agccgccggg acacggcacg aatcaaacgt 384121 cagccattga ggatctcgaa gagctgacgg atttgtacaa gcaagaactg aaccttcgcc 384181 ctgatcggcc gtttgtgctg ttcggacaca gtatgggcgg aatgatcacc ttcaggctgg 384241 cgcaaaagct tgagcgtgaa ggcatctttc cgcaggcggt tatcatttct gcaatccagc 384301 cgcctcatat tcagcggaag aaagtgtccc acctgcctga tgatcagttt ctcgatcata 384361 ttatccaatt aggcggaatg cccgcagagc ttgttgaaaa taaggaggtc atgtcctttt 384421 tcctgccttc tttccgatca gattaccggg ctcttgaaca atttgagctt tacgatctgg 384481 cccagatcca gtcgcctgtt catgtcttta acgggcttga tgataaaaaa tgcatacgag 384541 atgcggaagg gtggaagaag tgggcaaaag acatcacatt ccatcaattt gacggcgggc 384601 acatgttcct gctgtcacaa acggaagaag tcgcagaacg gatttttgcg atcttgaatc 384661 agcatccgat cattcaaccg tgatcaaaag cggacagctt cggctgttcc gctttttttg 384721 tgttgaatgc caatttctgc atggtataat agtcgaaata ctcaaataaa ggcaggtcga 384781 aacatgcgca cgtctcccag gatgaaatgg tttgtattgc tgtttacgtt tgttttcgcc 384841 atcggaatga actcattcag aaattccttt caatttttta tgctgccaat ggcagacgcc 384901 ttccatgccg acaggtcgct gatttcggtt tctgtcagca tttttatgat cacaaccggc 384961 atcgtccagt tttttgtcgg tttttttatc gaccgtttca gtgtcagaaa aattatggcg 385021 ctgggagctg tttgcatcag cgcaagcttt ttggtgcttc cttattcacc gaatgttcat 385081 gtgttttccg ccatttacgg tgtgcttggc ggaatcgggt attcctgcgc ggtcggcgtg 385141 acgacccagt atttcatcag ctgttggttt gacacacaca aaggtctggc gcttgctatt 385201 ttgaccaatg ccaactctgc gggcctgctg cttctctcgc ccatttgggc tgcggctccg 385261 tatcatgccg gctggcagag cacctatacc attttgggaa tcgtcatggc ggctgttctg 385321 ctgccgctcc tcgtctttgg gatgaagcac ccgccacatg cgcaagcgga aactgtgaaa 385381 aaatcttatg attggcgagg gttttggaac gtgatgaagc aatcccgcct cattcatatc 385441 ctgtacttcg gcgtgtttac ttgcggattt acaatgggaa ttattgatgc tcacctcgtc 385501 ccgatactga aggatgcgca tgtctctcat gtcaacggaa tgatggccgc gttcggggca 385561 tttatcatca ttggcggatt attggcgggc tggctgtcag atctcctcgg cagcagaagc 385621 gtcatgctat ccatcttatt tttcattcgg ctgctcagcc tcatttgcct gctcattccc 385681 attctcggaa ttcatcacag cgacctttgg tacttcgggt ttatcctgtt attcgggctc 385741 agttacacag gcgtgatccc gctgaccgcg gcgtcaattt cggaaagcta tcaaacagga 385801 ttgatcggat cgctgttagg catcaatttc tttatccatc aggttgccgg agctctcagc 385861 gtgtatgcgg gcggtttgtt ttttgacatg actcatggtt atttactgat tgtcgctgtg 385921 tgcatcgtgt ttgtgggttt atcggctgta atagagctgg tgccgttttt agataaacag 385981 aaggcaaaag aaacccacca ttcaatataa aaggatcagc actgtcaatg ctgatccttt 386041 ttaaatttga gtttttttgt ttcggtattt ttaaggataa tctccttgaa tctgttcatc 386101 tcctcttcgg agtgaaaaaa atgtttgggg atcgcaatat attggccact tgatgtattg 386161 accctgaaga tatttttata ttcgaaaaca gctgtaattt catcccaatt gaaaatgagg 386221 tcatattttt tagaacatat acgaattcct tcttggttca gagtatatgt tcttttggat 386281 ttcatccgtt cgttcttctt gtatgctctg gaaaacttca catatagaag aaggaggagc 386341 agcagtgtaa acagaacgga catcacgata atcaacatac tgttcataaa caagttaagc 386401 gcgtcacttc cataaacgat acggggccat ccgttaatga agttaactgc agcaaatatg 386461 gcgcaaaaca atagaaagta aaagcatgat atttttgcga tttgataaaa aaagatttct 386521 cttacatcct taaaagtgat ttctcctgga agattgatac tttcactagc atattgaatc 386581 atacggtaaa cctacacctc taaccatgtt tttcctttta gtctagcata atttctcatt 386641 tttttgcagg cataccaggg cgctttgttt ttttctccag attgatattg ctccccacca 386701 cgccaatcat aatacaaaca gccccggcaa gatgatacca ggccaggctt tcgttgagaa 386761 tcacaaatcc tgcaatcatc gtcacaatgg tagatacatg attaaaagcg ctcattttaa 386821 acgcctcaat tcgcgacagc gtatagttag acagaaatga agtgacaagt gaagacagca 386881 cgcccaaata cacaatggcg agaacgaagc cgggctcccg gaacggcaga aaataagtgc 386941 cgactgttcc cgccgctccg tgacgcacaa gggcgatggc gttgaagacg acaaagccga 387001 tggctgacat gatgtaggtg agctcggtca gcttgaaccg ctgcgtcatt tttctggcag 387061 cagtattgta catcgctgaa gacaaagcgg acaataggat cagcaaagac ccttttaagc 387121 tggctgattc cacgtcaacg cctttcatca caaaaataaa catgacgccg gcaacggata 387181 aaaccgtgaa ccccttttgc gtccacgttg ggcgttcctt taaaacataa gcggcaaaga 387241 ccatcgtgaa aatcggaatg gctgcctgaa taattcccgc ttcagaggag gacgagtaca 387301 caaggccgaa tgcctgaaag ctgaaaaata acgcgggata cagcagggcg agcggcaaaa 387361 tgtcaatgac gtcctttacg cggattgata gctttaccca gccgaataag atcggtacag 387421 tggccgcagc aaacgcaatg gtgaaccgat gcgccaaaat atcaaacggc tctgctgttt 387481 gcagtgcgat ttttacgaat agaaaggata aaccgataat gaacgaatat aaaatagccg 387541 ctatataagc gggggtttgc tgatgtttaa ccataatggg aagggctcct ttacctgaat 387601 tgcagcgccg gtcgctccct ttattgtatg gccgcggtca gaacggtaca atgagaaaaa 387661 caatgaactg taccggtaca aaacaggggg agaaggcatg gagaaatata tgagtctatt 387721 aacgaggata gaggagatga tgcaaagcac ctcatatcaa gaaggagaca ggcttccatc 387781 tatccgtcag ctgtccgccc gctaccaagt cagcaaaagc acagtgatcc gcgcgctgca 387841 ggagctggaa aagcgccacc ttatctattc tgttccgaaa agcggctatt atattgtgaa 387901 aaagtcaggg aaatcaaaaa gcgggcagcc tggccccatc gactttgcca catctgcgcc 387961 ggatcccgat gtgtttccgt atcttgattt tcagcactgc atcaacaaag cgattgatac 388021 atacaaaaac gatttgttta tttatgggac gccaaagggg cttccatcac tcatccgcgt 388081 actccgaaag ctcttggcca ctcaacaggt atttgcggat gaacggcata ttttcattac 388141 atcaggtgtc cagcaggcgt tatccttgct ttgtgccatg ccgttcccaa atgggaaaga 388201 gaagatcgcc attgaacagc cgggctacca tttgatggtc gaacagcttg agacacttgg 388261 gattcccgcc atcggggtga aacgaacgga agaagggctt gatatagcca aggttgagcg 388321 gttatttcaa acagaatcga ttaaattttt ttatacgatg ccgcgcttcc ataacccgct 388381 tgggtgctca ttgtcagagc gtgataaaca ggagcttgtg agactggcag aagcgtatga 388441 tgtctatctc gttgaggatg attacctcgg tgatctggag gaaaataaaa aggcagatcc 388501 gctgtacgca tatgatctgt cctcacatgt catctatttg aaaagcttct cgaaaatgat 388561 gttccccggc ctccgcgtgg gggcggctgt tttgcccgaa gcgctgactg acacgttcta 388621 tgcgtacaaa aagctgaacg acatcgactg ttcgatgatt tctcaagcgg cattggagat 388681 ttacctgaaa agcggtatgt acggcaggca taaggagaaa atcagagatt cttataaaga 388741 gcggtcgctg aggctacatc aagccattcg aactcacagg cagctgggaa gcggacgctt 388801 tacgttctcc agcgggcagg caccctgtat gcacacccat ctggtgcttc ctcaggatct 388861 gcccgcctca agagtgattc atagactgga aaaacaaggg gttctccttg aggcgataga 388921 ccgtcattat ttatcagatt atccgaaaga aaatctatta aaaatcaata tttccaatgt 388981 gaaaacggaa gatattgagc gcggtgtcaa gctgttgatg agccatttat aaaagctctt 389041 cgtacgagac cattgtgata tcctcgggga aatcagggtg tacggcgcat acagccattt 389101 tgtagccggg atcgacctca tacgttttga tatagcatgg ggaatggctg tccggaagct 389161 caatggatac ttgtccgtcc tggtgcaggc gcactgaaaa ggaatcaagc ggaagcgata 389221 agcctttgcc ttccttgttt gataaagctt tctttcattg accatagatg ataaaaatag 389281 tctgtctgct cgtccttgtc ttttgctaaa aggtcgctgt actctgtttt tgaaaagaag 389341 cgcttggcga tctcaaggct gatcggtttc gttttttcga tatctatgcc gatcggctgt 389401 gaatcaaacg cgcaaatgac ccagcgtccg gagtgagaaa tgttgaaatg agcgtcggga 389461 agatcaggga tgcacggctt cccgtattcc tgcgtgctaa agcggatatc ggatttgtcc 389521 aactgatact gcctgcttat gactgagcga acgagcacat ctcccagcag ggtgcggtga 389581 gcatcttctt tatgataaaa tctccggcat ttctcccgtt tttcaggtga tatgaaagac 389641 atgaaccgtt cattttcttc ctgtgaaagc gggcggtcca tataaattcc gtaaatcttc 389701 attctagatc ctccgtctgc aaaagattgt caaaaccatc ctatcatact tccacaagac 389761 tcatatagag gagaaaataa aaaaacaaag ccaaggcggc tttgttttag tgtacaggcg 389821 gagatgcttt cactgcggct gtccgccttg ccacagcata attcagcaac tggattgact 389881 ggggcaatga aaaacgcaaa ataagtccgg tgaggatggc ggtcaaaatg gtgccaaaac 389941 cgatcggtcc gcccatgccc catgccgcaa acaaaatggt taattccatg ccgttccgca 390001 cccattgcac attccagccg gttttttctg taatcagcat catcagtgaa tcacgcggcc 390061 ccgcgccaag gcctgctgat acataaacac cgacgccgta accaatcagc accacgccta 390121 gagagaagac gatgatcgag cctgtgtagg tcgagagggc aggcagaatg aaattgaaaa 390181 aatctataaa tacaccaatg agcaccatat tcaggagggc accaattttc ggccaagctc 390241 tcgtaaacaa tgacgtgaat ccgacgatga gcgctccaat aatgatggac cactggccga 390301 cggtaagccc gaagtgctga aacaggctgt aatgaaatgc atcccacgga ctaatgccga 390361 gtgcttttcc ttctatcgtc agggatacac caaaagccaa aatgatcaaa ccggcaaaat 390421 aaaatgtcca gcgcagaaca agttcttgct tcacgtgagg tcccttcttt cgtaaaaatc 390481 agtcgattgt cattgtagca catctgacag aagggcggaa taggcgaaag gggctcaaca 390541 aaaaaacagg gccgccggag gcgccctgtt tcagcgtgtt ggcaaaccct tgcattcgtt 390601 gtcaggcctg tgcttcggtg ctcacgaatt taacattagc tgtgctccaa tgctcgccct 390661 tcctagactt caaaggtttt caatcacgct gaaaatcaca aaatcctaaa acgaatatcg 390721 ttttaggatt ttgtcaataa tctgaaacag ggcgctgacg ctctgttttt cttattacag 390781 cgggttcaaa atccggttta agaaccgctg tgtccgttct tcttttggtg cggagaaaat 390841 ttgctccggc ggtccctgct ccacgataac gccgccgtcg atgaagatga cttcatccgc 390901 aacctcctgc gcgaacttga tttcgtgggt cacgacgacc atggtccagc cttcattggc 390961 caagtccttg ataaccttca gcacctctcc gacaagctcg ggatcaagcg ctgaggtcgg 391021 ttcgtcaaac agcatgagct caggctgtat cgccagtgcg cgggcgatgc cgacgcgctg 391081 ctgctggccg ccggaaagct ggaacggata taaatccatt ttgtccttca atccgacttt 391141 atcaagaagc tgaatcgctt cttttctgac ttcctctttg ttccgttttt gcacctgaac 391201 agggccctcc atcacgtttt cgagggctgt gcggtgcggg aacaggtgat acgcctgaaa 391261 caccattccg gattttcggc gaagctttag gatatccgcc tgtttcacct ttttggagaa 391321 atcgatggag aaatcatcaa atgcaagctc tccgcgattc gggatctcca gagcgttcag 391381 gcagcggagc agcgtcgttt tccctgaacc tgaaggccca agtatggcga tgacttttcc 391441 tttttcaatc ttcatatcta tcttttttaa aatttcattt tcaccgaatg atttgtttaa 391501 tcctttaacg gtaagcatac tcggaacctc cttatttggc cacgtagcgg tcaagacgcc 391561 gttcgatgac atgctggacg agtgagagca ggaagcagat aatccaataa ataaaggctg 391621 cttcaatata gatcactaaa atttgatcaa gattccgcgc gccgatttcc tgggcttttc 391681 tgaacagctc agcgaccaga atttgagagg cgagggatgt atctttaatc aggctgataa 391741 aggtattgga taatggcggg atcgacacac gaaacgcctg cggcaaaatg acgcggaaca 391801 gcgttttttg atgtgtcatg ccaattgtgt agccggcttc ccattgccct ttcggcacgg 391861 ataaaataga tgcccgaatg atttcagatg cataggcgcc gacgtttaat gaaaaggcga 391921 taactgcgct tggaaatgga tctaatgtga cgttaaaggc cgggaacaga tagaaaatga 391981 tgaacaattg aacgagaaga ggagtgccgc gtattgcgga tacgtatacg ctgaacaccc 392041 atctcaaagg tctcactttc gacattctgg caagcgccgt aatcagcgcc aggatcattc 392101 cgaatataaa ggaaagaatc gtaaggggaa tcgtatagta gattccccct gaaagtatcg 392161 gccagaatga ctgctgcacc agatcccacg ggatcgccgt gccaagcgtc aatgccggca 392221 gattatttag aaacatcttc gccgaaccat tttttagaaa ttttagaaag agtcccgtcc 392281 tctttcattt cttttaatgc tttgttgact tgatcaacaa cctcgccgct tcctttacgg 392341 aacgtgaaat atgttgactg aggctcacct gtttcaaacg cgattttcac gtttttattg 392401 ccagatgttt ttaagtagtt caatacggca agcttatcgt tgtatgtcat atcgacgcgg 392461 ccttgctgga tcatttgaag ggcctgcgcc atgccttcaa cgccttctac tttagcgccg 392521 gcatttgtag ctaatttgtt gtagttgctt gtcagtgatt gagctgacgt ttttcctttt 392581 acatctgctt cagacttaat atcgttgttg tcttttttcg ttacgacaac ggctcttgat 392641 gttgtgtatt tatctgagaa atcatatttg tcttcacgat ctgtttttcc gacttggttg 392701 gcaacaacgt caaaccgttt ggaattcagg ccggcaaaca tactgtccca ttgtgtttcc 392761 ttaaagtcga ctttaagccc gaggcgtttt gcgacttctg tgataacttc gacatcatag 392821 ccagtcagtt tatcagtgtc tttgtcgtgg taagtgaacg gctcatatgt tccttccgtt 392881 ccgactgtga gcacaccttt tttcttaatt gaagcccaaa gatcgccatc tttggcatta 392941 tcttttgact gattgtcatt tcctgctccg caagctgcaa gagctgcaat acttacgacc 393001 atgaataaag ccaataatgc ttttttcatc ttattcccca cttttctggt tgattttatt 393061 gaaataaaaa attagcttac aaatctaaag gataactttt ttttagtatg agtcaagtat 393121 ttggttttca taagacaaaa tcttttaaaa taaatccaaa aattgctgtg ccggtttagg 393181 caaataactg tccgttctcc acatgacagc cggtgtcata atgaagggat tattttcgat 393241 atggacggtg tgaacgtgat ttctcatatg aacgggaatc attgtgacag gcaaaataga 393301 cgcgccgaat ccggatgaca cgaggctgag caaagttgca gagtcgtggc attcacaaac 393361 aatgcgcggc tccaggttca aacgatgaaa ttcattcatg acctgattat agacgccttt 393421 tccgttgaca ggccgcagca ggatcagcgg aaatgaagga atgtccacca tcttaatggt 393481 gtctccgcac ggatatccgg cttcatctga aagcacgagc acacatggaa tgtcatcaag 393541 ctgcttgaat tgtactgtgt cacttttgat cagtgttgtc gtgaccgccg catcgatttg 393601 ccggctttcc agcagttcca acagtgtcgc gggttcattt tcccaaatat taaaggtgag 393661 atgggggtat ctctctttga tctgtgttac tttttcaagc atcagagccg cgcaataaat 393721 cgttgatccc acggcaagtg taccggctac ttcctccttc agctcctgta cctcaatgac 393781 tgcatcttca aacctatgca gaatctcttt tgctcttttt agaaaaacag ctccttcata 393841 tgtaagagtc atttgttttt tcttgttacg gtcaaacaga acaacaccaa gttcgtcctc 393901 cagctgtttg agctgcctgc ttaaaggcgg ctgcgccatg tgaagctttt tggctgcgga 393961 cgtaattttc tgttcttggg caatggtaat gaagtatcga agctggcgaa tatccaaaag 394021 aaagcgcctc cttatcatac cttttaggta ttaattatag atttaataga tatttttcat 394081 atggatatat caggagtatg attgaaatga aagcagaatt caagcgtaaa ggagggggca 394141 aagtgaaact cgttgtcgga atgacagggg caacaggggc cattttcggg gtcaggctgc 394201 tgcagtggct gaaggccgcc ggagtggaaa cccatctcgt tgtgtctcct tgggcaaacg 394261 tcacgatcaa acacgaaaca ggctatacgt tacaagaagt agaacaactg gccacataca 394321 cttactcaca taaggatcag gcggcagcca tttcaagcgg gtcgtttgat accgatggaa 394381 tgattgttgc gccgtgcagc atgaaatctc tcgcaagcat tcgcacagga atggcggata 394441 atctgctgac acgtgcggcg gatgtcatgc tcaaggagag aaaaaaactc gtcctcttaa 394501 cgagagagac gcctttgaac caaattcatc tcgaaaatat gctagcgctt acgaaaatgg 394561 gcaccatcat tcttcctccg atgccggcat tttataatcg gccgagaagc ttagaggaaa 394621 tggttgacca tattgttttt agaacgttgg accaattcgg cattcggctt cctgaagcga 394681 agcgctggaa tgggattgaa aaacaaaaag gaggagcttg atcatggctt atcaagattt 394741 cagagaattt ctcgctgccc ttgaaaaaga aggacagctg cttacagtga atgaagaggt 394801 aaagccggaa ccggatttag gggcctccgc acgggcagcc agcaatcttg gcgataaaag 394861 ccctgcgctc ttatttaaca acatttacgg ctatcataac gcgcgaattg cgatgaatgt 394921 catcggctct tggccaaacc atgccatgat gctgggcatg ccgaaagaca caccggtaaa 394981 agaacagttt tttgaattcg caaagcgtta tgaccagttt ccgatgccgg tcaaacgtga 395041 ggaaacagcg ccatttcatg aaaatgaaat cacagaagat atcaatttgt tcgatatact 395101 gcctcttttc agaattaacc agggtgatgg aggctactat ttagacaaag catgtgtcat 395161 ttcccgtgat cttgaggacc ctgacaactt cggcaaacaa aatgtcggca tttacagaat 395221 gcaagtcaaa ggaaaagacc gccttggcat tcagcctgtc ccgcagcacg atattgcaat 395281 ccatctgcgc caagctgaag aacgcggcat caaccttccg gtcactattg cgctcggctg 395341 tgagccggtc attacaacgg cggcatcgac tccgcttctc tatgatcaat cagaatacga 395401 aatggcaggt gcgattcaag gcgaaccata tcgcatcgtc aaatcaaagc tgtctgatct 395461 tgatgttccg tggggcgctg aagtggtgct tgaaggtgag attattgccg gagagcgcga 395521 atatgaaggg ccgttcggtg aattcacagg ccattattcc ggcggacgca gcatgccgat 395581 tatcaaaatt aaacgcgtct atcacagaaa caatccgatc tttgaacatt tatacttagg 395641 catgccttgg acagaatgcg attacatgat cggcattaac acatgcgtgc cgctttatca 395701 gcagttaaaa gaagcgtatc cgaacgaaat tgtggcagtg aacgccatgt acacacacgg 395761 tttaatcgcg attgtttcca caaaaacccg ctatggcgga tttgcgaaag cggtcggcat 395821 gcgcgcactc acaacgccgc acggactcgg ctactgcaaa atggtcatag tcgttgatga 395881 ggatgtcgat ccattcaacc ttccgcaggt catgtgggcg ctttcgacca aaatgcatcc 395941 gaaacatgat gcggtcatca ttccggactt atctgtcctg ccgcttgatc cgggatccaa 396001 tccatcagga atcactcaca aaatgattct cgacgccact acaccggttg cgccggaaac 396061 aagaggccat tattcacagc cgcttgattc tccgctaaca acgaaagaat gggaacaaaa 396121 actaatggac ttaatgaata aataaggaaa ggatgttcga aatgcataca tgtcctcgat 396181 gcgactcaaa aaagggagaa gtcatgagca aatcgcctgt agaaggcgca tgggaagttt 396241 atcagtgcca aacatgcttt tttacatgga gatcctgtga accggaaagc attacaaatc 396301 ccgaaaaata caatccagcg tttaaaattg atccaaagga aacagaaaca gcaattgaag 396361 ttccggcggt gccggaacga aaggcttgat ccgcgtgaac tgtatgtcag accgtctctt 396421 tgagctgctt gacgggagct gcctgaatga gaagcagcat gaggccttcg ttctgcaaac 396481 agtatcagag gatggctggc cgcatgccgc tatgatcagt gcaggtgaaa tcatcgcgct 396541 gagccgaact gatatccgaa tcgctctgtg gaaaaacaca atgacttcgg ccaacatcct 396601 tcgcacagga aaagcacagt tcacggcgtg gtggaaggga gcggcctatt atgtaaagct 396661 tgaatgcgcg cctttaccgc ctttgaaaga tgccgaatat gaaagagacc gtttttcctg 396721 ccgcatcgtt tcagtgaaag aggacgttgc gaaatacgct gatttgactt caggtgtccg 396781 tatacagctt cacagccctg aagaggtgct gagcagatgg aaaaagaccc tggaagattt 396841 aaaacggtaa tatcgatagc ctgacgccat gcgtcaggct ttttttatat aatgaaaaca 396901 aaagggggcg tgagaaatgg aacgtgcggg gatctgtcac tcggacggct ttgatttagc 396961 ttatcgaatt gagggcgagg gcgcacccat ccttgtgatc gggagtgcgg tttactatcc 397021 gcgccttttt tcctcagata tcaaacagaa atatcaatgg gtctttgtcg accatagggg 397081 atttgctaag cctaagcggg agcttcgtgc ggaggattcg aggcttgatg ctgtcttggc 397141 tgatatcgaa aggatgagaa catttcttca gcttgaggat gttactatcc tgggacattc 397201 cgggcacgct tttatggctt tagagtatgc caggacatat cccaaacaag ttcggaaggt 397261 ggcgctcttt aatactgcgc ctgataacag tgaagaaaga cagcgaaaaa gcgaatcatt 397321 tttcatggaa acagccagtc ttgagagaaa gaaacgcttt gaaaaagaca tcgagaattt 397381 gccgcaggac atcgacaaag atcctgaaag gcgctttgtg cacatgtgta ttcgcgctga 397441 agcgaaaagc ttttatcaag agcggccgca tgctgctgcc ttatgggacg gtgtattcac 397501 gaatatgccg atcattgatg aattatgggg caatacattt gcccggattg atcttcttca 397561 gcggttagct gatgttcgta tgccggtgta tatcggatta gggagatatg attatttggt 397621 tgcgcccgtt tcgctatggg atgctgttga cggtttatat ccccatgttg ataaggttat 397681 ttttgaaaag agcggccatc agccgatgct ggaagaaccg gaagcctttg atcaaagctt 397741 caggaaatgg cttgatcaat aaaaaacagc ccgcagatca acatccgcgg gctgtttctg 397801 attataagac ccctttcatc gcgcgtttga tcaccggcga gagcagcagg agaatgccgc 397861 caagaacgat agaaatcaaa ccgatggtgc cgaagtacat tgtttcagga attttatcaa 397921 acaatccggc tacttgggca ttgatcgctt gggctgctgc gttcgtcaga aaccacatac 397981 tcattgtctg tgcagagaag gcagctggtg ccagtttcgt tgtcacggat aaaccgactg 398041 gagacaggca cagctctcca agcacgacaa gcaggaagct gagaacgagc caaagcgggc 398101 ttacgagtgc ttcttttcct tgcatagcag ggaataccat aatgataaat gacaatccgg 398161 ctaaaataat tccgattgag aatttaactg gtgtagacgg ctgacgtttg ccaagcttca 398221 tccagagcca tgcgaatatt ggcgcaaaaa tgacaacaaa caatggattt aatgattgga 398281 accatgatga ctgaagttcg aatccgccca atgaaagtct tatgcgttca tcagcgtata 398341 ccgcaagaat ggtcgctccc tgttcctgaa tggcccagaa catgacagca ccgataaaca 398401 aaggaacgta agcggcaaga cgggattttt ctgttttgtc cgcttttttg cttgtaaaca 398461 tgatgatgaa ataaatcaca ggaatcaaaa taccgagaat acttacaagg tcaatgaaac 398521 gtttgatcgt cagcacgcct gtttgtacag agataatcac tgcgatcgcc acaatgataa 398581 caccgattcc ggtgccaatt gcagattttt tagacagcgg attcggcaca ttggaacctg 398641 caagcccgag gtttttcttt cttgtcaaag caaatacgat aagtccgaga agcattccga 398701 ccgcggcagc tccgaatccg agatgatagt tgtacttctg tccgagtgtt ccgacaatta 398761 acggcgcgag taaaccaccg aggttaatcc ccatgtagaa aatactgaaa cctgagtcgc 398821 ggcgcgggtc ttctttcgtg taaagatccc caactacgct tgaaacgttt ggttttaata 398881 agcctgttcc gacaatgata agcaccatac tgatatagaa tgctatcgaa ctgcccggat 398941 aggcgagtgc aatgtggccg aacataatga atatgccgcc gtaaaacacg gtgtttgcgg 399001 taccgaatac ccggtcagcg agccatccgc caataatggt ggacatgtat acgagtgatc 399061 cgtaaatcga cataatggca accgcagtgc ccttgtcaaa gccgagccct ccgtttaccg 399121 tctctgtata caaatagtaa agtaagattg ctctcattcc atagtaagag aaacgctccc 399181 aaaattcggt gaaaaatagt gtaaatagtc ctcgcgggtg accaaagaac cctttttgcg 399241 ggacgctttt aatgatactt tcgttatcaa tcgaagccat gtcagccaaa ccctttctaa 399301 aaaaagtgta ttataaaaat catattctta tataatactt gtgtcaatat aatttatact 399361 catttcaaat agttccatat tggaaaaatt ataaatacct aaaaatagtg atttcctcct 399421 aatttttaaa ctttttatcg tgagattttc ttacacaact attcctttat atttttttaa 399481 taaaatttta gagaaatgta caagcagatc gggcctttgt gagtaacatg atagtaatca 399541 tagagaagga ggctcgcaat tggctgaatt catattaaat gcagcggatt tcggtgttcc 399601 tagagatggt aaaacggatt cgacagaacg gattaatcag tgcctcagta cagctgtttc 399661 gaaaggctat catactgtct ggtttccaaa gggaacatat ttaatagacg caacgcttgg 399721 cggagatctt aatcagaggt ttcgaaacgc ggggatcatt gttcccggca accttgagat 399781 tatgatggac cccgaatgta tcatgaaagt gataccgaat agttcgtggg gttattccgc 399841 attttatgta ggcaagcaag agaatataac tatttccgga ggacaaatta tcggcgaacg 399901 ggatgagcat acgtatgcct cggcggggat aaggtcaacc catgaatggg gctttggcat 399961 atgtattgaa ggatgctcga atgttgtcat tgatgatgtg aaaatttccg attttaccgg 400021 cgatgggatc atagtcagcc caaggggatt aaagaccaat caagattatc gaacgtcaga 400081 gcaaattatc atccgccgct gtgaggttcg gcggtcgagg agaaataaca tttccattac 400141 cggatgtgac atggtcacgg tggaggaatg cttgattgaa gatgccggaa cggggaatgg 400201 aacagcgccg aaattcggaa ttgacattga aggatatggc gaaggtgacg ttgattatga 400261 ggaaccgatt aatgtatcaa ttcgcaataa ccactttgtt ggaaacgttt caagttctgt 400321 gaccaatttt aacgggtatg gcattttaat agaaggaaat cactcagaca atacaatcag 400381 ctacggatat gggacgcaaa cagtgatcaa gggcaatatt ctgagacgcc ctgaagacgc 400441 ggcggctgcg ccaagagtcg ggataaccgg actcggtgta tcacaaggaa aagagaccag 400501 tgatgcagtg atcgctggca acctcattac cggattttca actggaattg atgtcagggg 400561 aaagagcgtt cttgtgacga acaacaaaat cagcaacttt gaaaacacag ggatattggt 400621 ttatcagtcc tccgacgtaa aggtagacgg aaaccaaatt caaaacggac tgtctgaaac 400681 aaggcgcagc atcggtcttc gcgcagtgct gtcagatgac atcgcatttc tgaataactg 400741 tctcattcaa gtcgttgacg gtgtgaacgt ttccggcgga aatatgatca ttaaagataa 400801 tctcctgaga aaattcagcc ggggcatttg gattgctcaa gggaacgcgg tgattgaagg 400861 gaatacactg aatcctgacg cgtttgaagc agtgccggaa tcatattctg tttccgtcac 400921 aaacaatgcc ggcgccatca tcaaaaacaa tacatttaaa gagttcaaaa attaccccat 400981 ttattgctcc acaagtgcaa aaacctcaat tatcggcaac cacttagagc gatccccgct 401041 tttggtcacc atctatatca gcgcaggtgt gcatgagatt tttgataata ccatttcagt 401101 caacagaaca gccgggaatc cgattgtgat ttatctcaat ggctctgcag gctctatcat 401161 ctctggaaac accatcaata acctctccgc gggcactgcg acagctattc aaacaaacac 401221 gtcaaccaat tccaaaatca tcggcaaccg catttttaaa gggaccatca acaaacacag 401281 cagtgataca atagacggca atatgattgt ctgaaaaaag cgcccccctt taggggttct 401341 tttttttcga tttatagatc acgtacattt ctctcacaag tactaacaca aaaaataaaa 401401 gcacgaccca ttccgcaaat gttgtcatct taaagctgga catattgtta taaacggctt 401461 ttgttaaact gaacccttga agcatgtcca tcaacacaga aatagctaat aaacaaatta 401521 atatgaatcc ggtcacgccc aatatcttca tgcttcatca tcctccgctt ttagtgtcta 401581 tctttggcgg agaagttata ccgcatctaa ccctaatgca taatctcaat tttaaaagga 401641 agaatatgag aaaacgacaa ggaaaggtat ttgtgtatgc ctttattttc taagcgaaag 401701 aacaataccg attcaaaaga caagcagaat acagacgaaa ggaatcagga acagcagcaa 401761 gaaaaagaaa ggccggttct catttctcca agtttagcaa agaatatagc ggaaacgaaa 401821 aaggaagtcg gaagcagctc tgacgtcatc attcgcgaga ttaaaatcgg ggagcaggat 401881 catgtccacc tagctgttat ctatatttct gggctggtcg ataataacac gatccatgag 401941 tcgttaattg acccattggt acaggatgag tctatccaga atactcatgc gatccagcaa 402001 attcttgaaa aaacgctccc gctgggcggg gtgaaagcgg aaaagagctg ggacaagctt 402061 ttttccgagt taatgcttgg caatgcgctc atttttgctg atggccatga tgaagctttg 402121 atttgcagca ctcaaggggg agagcagcgc tccatccaag agccgagcac ccaggtgtca 402181 ttccgcggcc cgcgccaagg gtttacagag tctctgcaaa ccaatatttc catgatccgg 402241 cgatacatta aaaatccgaa tttatgggtt gaaaaaatga aaaaaggttc tgttacgaat 402301 acggatatcg ctctcatgta cattcaagga atatgtgatg aaaaggtgct gaaggaagtg 402361 aaacagcgcc tggaaaaaat agatattgac agtattttgg aatctggata tattgagcag 402421 ctgattgaag atgaaacctt tacgacgttt ccgactatgt atcatacaga acgccctgat 402481 gttgtagcgg gtaatctgtt agaaggaaga ttcgcgatta ttgtggacgg aacaccgttt 402541 gtgcttattg ccccagcctt atttgtccag ttttttcagt ctgttgagga ttattattcg 402601 cgttttgaca ttgcgacaag cataagaatt cttcgtgttt tagtcttttt catttcgctt 402661 gtggcaccag ctgtatacgt ggcagccacg acgtttcatc aagaaatgat accgactcag 402721 ctgttagtgg tcattgcggc ccagcgggaa attgtcccgt ttccggctgt tgtggaggcg 402781 ctgacgatgg aggttgcttt tgagattctg agggaagcgg gagtcaggct gccccgggtt 402841 gtcggctcgg cagtgtcaat cgtaggcgcg ctcgtaatcg gccaggctgc cgtacaggct 402901 ggtatcgtct ctccggcaat ggtgattatc gtggcactca ccgcgattgc gagcttcgca 402961 acaccggcgt ttgcaatggc gatttcagcc cggcttattc ggtttatctt tattattgcc 403021 tcagctgtta tgggttttta cgggctgatt ttagggatca ttatgatgtt tgtccactta 403081 tgcagtcttc gttcattcgg cgttccatat atgtcgccgc ttgcaccttt ttcttcacaa 403141 ggcgtaaagg acgcgctttt ccgggttccg tggtgggccg atgaaaaaag gccggaatcg 403201 gtcagcaagg aagataaggt gcggcagggg aaagatcaac gcccagagcc ggccgcttca 403261 cgaggaatgg tgaacaaaga tttggaagaa ggggatcaga atggtacgta aatgtctatt 403321 agccgttctc atgcttttga gcgtcattgt gctgcccggc tgctgggata agcgggagct 403381 gacggatctt gcgattatct cggcgattgg catcgatcgg acaaacgaca gcaactacgt 403441 gctgcatctt caaattatca atccaggaaa tgttgccggc ggccttcagg gaggcggtgc 403501 tggagacagg ccgcctgtat ctgtctattc gattgaaggt aacaatataa cggaagcact 403561 cagaaaagcc tccatgaagg tatcacggcg gctttatttt gcccatacca atctagtcgt 403621 gatcaatgaa aagctggcaa aagaagaagg tttggatttt gtattagata atcttgaccg 403681 ggacacagaa ttcaggacaa cagcaacatt cgtcgttgcc cataaaacaa aagcagaaaa 403741 tattgtgaaa atcttgacgc cgattgataa aattccgtca aataaagtca ataaaacact 403801 cgatttcacg gaggcacaat acgggcgggt ggtcaaaatc aatattcagg acgttttgaa 403861 aacacttgcc gccaacacta tggcaccggt catccccgga tatatgatga ttggtgacga 403921 taaaaaagga gtcagcatgg aaaacacgca ggcgactgac ccgaaagcca ttcttcaggc 403981 agatggtttg gcggtttttg ataaggcagg atatttaaag tattggctgg aagatgatga 404041 aagcgtgggg gcagtctggc ttatgaataa gatccagcat acgtttatta atgctgactg 404101 gggcaagacg aaggatgcgg tcagcttgca ggttacccat caagatacaa agctggtacc 404161 gaaaatgcgg aacggacgcc cgtacatcca tgtgaaagtg tcggttgaag gtattataga 404221 tgctgtcaaa taccctttcc aattgtctga tcccaaggtg ctggccgcta ttgaaaaagc 404281 gctcaacaaa gagcttgaaa aggaaatcag ccatactgtg aaaaagatta agaagaataa 404341 aatagatttt atcggttttg gtgacacgat atatagaaag tatccggagc agtgggagaa 404401 aatgaaggac acttgggaca aagaatattt gccggaactg cccatcgatg tgaaggccga 404461 gacgtatatc agaaggacgg gattgcgaaa caatccgatc aaacaccagt ttaaagatga 404521 ttaggtctga agaaagggga agtgacagat ggaaaaagcc agaataagca taaggcagtt 404581 gtttgtcatg attatcattt ttgaactggg cagctcctta ttgattacac cgggatcaat 404641 ggcgggcagg gatgcttgga tagcagtttt attaggctgt gcgatcggac tgtttctttt 404701 ctatttgtat caaggcattt atcaatgtta tccgaattct tctccgaaag aatatatgga 404761 tgatatgctg ggaaccaagc tgagctggct gttttcattt ctctatatct tgtactttgc 404821 ctatattgcc gcaagggtgc tgcgtgactt tggagaaatg ctgctgacgt ttgcttatca 404881 tgatacacct atcattattg taaatgcttt attaatggta gtaagcatat atgccgtaag 404941 aaaaggaatt gaagtactcg cacgcgcggc cgaacttctt ttcggggcca tgtatttact 405001 gggcgcgatc ggccttgtgc tgattattgt ctcagggact atagacccgc acaatttaaa 405061 gccggttttg gcaaacggca tttctcctgt ccttcactct gttttcacac agaccatgta 405121 cgttccattt ggtgaagttg ttttatttgt gatgattttc cctaacctga atgacagaaa 405181 agatgtgaaa aaaatgggga tgatcgccat ggctattagc ggattgattg tggcgctcac 405241 cgtggcgatt aatattagcg tgcttgatgt tgatcttaca ctcagatccc agtttccgct 405301 tttaagcacg atccagacaa tcaaggtcga agaattttta gaccggctcg atgtcttttt 405361 tatgctggcg ctgatcatcg gcggcttctt taaggtcagc ctctacttat atgccactgt 405421 ggttgggaca tctacgctct ttaaggaaaa gaacccctct caattggctt atccgatggg 405481 attgggcatc ttaatccttt ctataacgat cgcgactaac ttttcggagc acttgaatga 405541 aggcctgaac gtggtgccgc tgtatattca tttgcctttt caattattgt ttccgctctt 405601 tctgtttatt gtggccgttt ggaaaaagaa acgaagagag aagtcaaaag gggaggaagc 405661 aaaaaaatga taaaaagagc ggggggatgc ggccgccgct ctttttatgt tcacttctat 405721 ataaaagggg gatatagggt gcgcccctgt ctgcactggc agaggcgcgt tttgttatac 405781 gactgcgacg ttttccttca cagtaaaact tcctcttgaa agtctgatat tgatgtctga 405841 cacttttgca atttgttcat cgtgcgtcac cataatgacg catttatctt ccttgtgcgc 405901 cagatcctga aagagccgta cgatctcttt tgatgtgtcc tcatcaaggt ttccggtcgg 405961 ttcatcggct acgataagat ccgtgtcaca gcagaaagcc cttgtaattg atacccgctg 406021 ctgctgtccg ccgctcagtg tgagcacttt ttgccgggct tgtttttcgt tgatgccaac 406081 cttctgcagc atgtcaagcg catatgattc tttgttcttt tctttagaac ctgtgatttc 406141 catagcggtt gtgacgttct gcaaagccgt catatacggg agcaggttgt acgcctgaaa 406201 gacgattgat acatattgat ttctgaaatt ggttaagccg attttagaaa ccgcttttcc 406261 gtcgtaaagg atgtttcctt cttttggtgc gtcaagtccg cctgccagag acaggaaagt 406321 ggttttcccc gtccctgatg ttccgacgat tgtgtagaat tttccttttt gaaagctgat 406381 gttaatatcc tgaaacaatg gctggctttt gtttttatac cagtagccga cttgttgaaa 406441 ttgtaataag ctcataggtt ccgcctcttt ctattcctgt tttgtcaata tcgttttcgg 406501 atgaagccgc agtactgaaa ttgacggcag caatgttgca atgattgcga ttaggatgcc 406561 gatcccgcca agtataagca tgtcgttcat agaaaccgcg acgttcagtg aatcgataac 406621 gtccacgttg gatgaactgt ggccgaacat tttgccgccc atgccgccac cgccgccggg 406681 catttgtccg cttgcggttt gcgttgaatc ggttgatgaa ctgatttgct gggataaaag 406741 ctgatttcca agctgattcg cgacgagatt tcccgtcaca gatgcaaggc cgatagcgat 406801 aacggccaca atcagaatct cagtcaagaa ctgtccaatc aatttccatc gtttttcacc 406861 gatggccatt aacacgccca tttcgtattt gcgctccctg attgacatca tgacaatcag 406921 gccaagaatg acggcgcctg ccactgatac aagatacacc acgtttttag agaaagaagc 406981 cacattttca atcggtccga ccatttgctg gtaaagctga tcgtttgtat tcagtgtgta 407041 cgtatcaaag tcaattgatg ttttcttcgc tgcttttacg aaagtatcca tatttttcgc 407101 gtcgtccata tagtaaacag ctgagtcaat cgtattttta tagtcgtcgc ctttcaatgc 407161 cgctgttgct gtgtaaggcg tataaagctt gttataagga tttaagaaag agaaattttg 407221 ggcttggtca tcacctgaag atgttgtttt ataaataccg acgatcttca gttttactgt 407281 tgtatcctca tccgttgctg attcaattgt gatcgaatcg ccaacgctta aatcattttc 407341 ttccgctaat gtttcgttga tcactgttac ttttttgccg acatctgatt ttgtaatcgc 407401 gcgtccgtct gtgatttttg aatctccgtc agagaaatca tcgactaacg ctgtgctgat 407461 gacaccttca atagaaagat cagcttgaac catttgcggt ccgccttgtc ctccgccttg 407521 actgttttta gcgtttgagc ttgaactgct ggagctggaa tcacttgaac tagagctttc 407581 aatcgcatca aagtttcccg cgttggctga agctgatgtg gtgtaattgt agctcttcac 407641 atgatcaagc gctgcaagct tattcgcatc agacactttg atcggtgtgg attcgaagct 407701 gcgcttttca ccgctgtcct gctgtttttc catttgcttt tggcggtcaa cctgaagtgt 407761 cacgcttcca ccgagttcct gtctggccag ttcgcttgac ttttgtgctg ccgactggat 407821 ggcgaggcct gatagaacaa agacacatat gactgtaaac acaaataatt gcaataacgt 407881 ttttcccttt ttagccttca tattccaaaa ggcccgtttg ataaagttca tttatgttcc 407941 tccgtatagg tatttttatt gataagaccg cctctggggc gcgtcccctt gctgataaat 408001 taatagtagt ccaaaggtat gaaaaaaata tgaacaatct atttctagtt gatgaaataa 408061 aaactaacaa ttgtgaaacg caaaaccttc tgtttaaaat ggtgctatta tataaaaaag 408121 catcaaaaca accggaggat ataatgaaaa tattaatgat agaagataat gttagtgtat 408181 gtacgatgac ggagatgttc ttttttaaag aaggttttga agccgaattc gttcatgacg 408241 ggttagaagg gtaccagcgt tttacggaag aaaattggga tctaatcatt ttggatatca 408301 tgcttccatc tatggacggc gtgaccatct gcagaaaaat aagagagaca agcacggtgc 408361 cgattatcat gctgactgcc aaagacactg aatcagatca ggtcatcggt tttgagatgg 408421 gggcggacga ttatgtcaca aagccgttca gcccgctgac attggttgcc cgcatcaaag 408481 ccgtcatcag aagatataag gcgacaggca aagcggttat tgatgaagat atgattgaaa 408541 cggaatgctt taccattaat aagaagacga gagaagtatt attaaacgga gagcctgtag 408601 aaaatctcac gccgaaggaa ttcgatctgc tttattacct tgtccaaaat ccgcggcagg 408661 tgttctccag agaacagctg cttgagcagg tatggggcta tcaattttat ggagatgagc 408721 gaacggttga cgttcatatc aaacggctgc ggaaaaagct tgccagcgag gacaagcctt 408781 tcctgtatac tgtgtgggga gtagggtata aatttgatga agattaaata tttatatcag 408841 ctgctgctaa gccatatcag cattttgatt ttagcgtttg tcattatcat ttctctgttt 408901 tcccactttg tgaaggaatt tgcctatcag aacaaagtag aggaattgac gtcatatgcg 408961 gtgcagattg caaatgaatt ccaatccggc caggtggaca tgcgcaggct ctatccttat 409021 caggacattt taagcacaag aaagacgcaa tttatcatct ttaatgaaga gcagcagcct 409081 tattttcttc ctgaaggctt tcatcaccca ccaagggaac agctgaagaa atcagaatgg 409141 aataagctga aaaaagggca gactgtcacg atcagggcag atggccgttt tgatgatgaa 409201 gtgtcccttg tggcgcagcc tatatttgtt cagaacgaat ttaaaggcgc cgttctgctg 409261 atttctccga tcagcggtgt tgaacagatg gtcaatcagg tcaacctcta tatgttttac 409321 gctgtgatca gcacgcttgt gattacgatt cttgtgagct ggcttctgtc caaattccat 409381 gtcaagcgga ttcaaaagct gagagaagcg acagataaag tggcttccgg cgattatgac 409441 atccatttgg aaaacagcta cggggacgaa atcggcgtac tggcgtctga ctttaatatc 409501 atggcgaaaa aactaaagca gtcaagggat gaaatcgagc gccttgagaa gcggagaagg 409561 cagtttatcg ctgacgtgtc acatgaatta aaaacaccgc tgacgacgat caacggtttg 409621 gttgaagggt tgaacagcca tacgattcct gaggataaaa aggataaatg cttctcgctg 409681 atcagtgagg aaacgaagcg catgctgcgg ctcgtaaaag aaaatctgga ttatgaaaaa 409741 atcagatccc agcaaattac cttgaacaag ctagacgttc ctctgatcga ggtgtttgaa 409801 atcgtgaaag agcacttgca gcagcaggcg gaagaaaaac aaaacaagct gatgatccaa 409861 gtagaggatc acgtcatcgt acatgccgat tatgaccggt tcattcaaat tctcgtcaac 409921 attacgaaaa acagcatcca atttacgcaa aacggtgaca tttggctgcg cggaatggaa 409981 ggttataaag agacgattat tgaaattgaa gacacgggta tcggcattcc aaaagaggat 410041 attgagcata tttgggagcg attctataaa gcagatattt caagaacgaa cacagcatac 410101 ggtgaatacg gactcggtct ctcgatcgtc aggcagctcg ttgaaatgca ccagggcaca 410161 gtagaaatca agagtgaaga agggaaaggc acaaagttca tcatccgcct tcctttaacg 410221 gcaaaacagc aatagcatac agggcggcgc atcaactgat gcatccgcct tttttgcaca 410281 ccgcttcggt ttattgcgtg ctcccgaaaa caaagattgc gtgtttttcg ggttgggacg 410341 gcctataaac atgataaaat atgacataaa cagtttttga tgggagaggg tgaaggaatg 410401 aagagtgggg taattccttc ttcagcggtc ggtcaaaaaa ttaacgagtg gtacagatat 410461 atccggacat tcagcgtgcc ggatgccgaa gtgttaaaag ctgaaatcca gcaggaactg 410521 aaacacatgc agcatgattc caacttgctg ctttattatt cactaatgga attccggcac 410581 cagcttatgc tggattatct tgagccgtta gagaaattaa atatcgaaga ccagccaagc 410641 ctgtctgaat tatcaagaaa cattgacagc aaccaggcag atctcaaagg gctgctcgac 410701 tattacgtga atttttttcg cgggatgtat gaatttgata agcgggaatt tatttctgcc 410761 attacatact ataaacaggc ggagaaaaag ctctcctttg tcgcagacca tattgaacgg 410821 gctgaattct attttaaaat cgcggaagct tattattata tgaagcaaac gtatttttca 410881 ttgattaata taaaaaacgc ctatgaaatt tacgtggagc aggaaaccta taatgtgaga 410941 atcattcagt gccatttcgt cttcggggtc aacctgatgg atgaaagaaa tttcgaacaa 411001 gccgcacgcc atttcaaatt ggcgctcaac atggcccaag cagaacaaaa agcccagctg 411061 gttggaagag catactacaa tctcgggtta tgctattaca atcaagacct tctagaccct 411121 gccattgatt actttgaaaa agcggtctcc acatttgaaa gcagcaggat cgtcaattct 411181 ctcccgcaag cctatttttt aatcaccctg atttattata aacagggaaa acatgataaa 411241 gcttcggaat atcacaagcg gggctatgaa tatgctaaag aaacagacga tgcagactat 411301 gccgtaaaat tcgagttttt gcaatcccta tatctggatc agcccaatga agaaggaatc 411361 gaacgatgtt tccagtactt aaaaaataaa aatatgtacg ctgatataga ggatttagcc 411421 ctagaagtag caaaatatta ctatgaacag aaatggttta aactgtctgc ttcctacttt 411481 ctacaagttg aagaggcaag aaaacaaata caaaggagtg aaggtttgta tgaaattgaa 411541 atctaagttg tttgttattt gtttggccgc agccgcgatt tttacagcgg ctggcgtttc 411601 tgctaatgcg gaagcactcg actttcatgt gacagaaaga ggaatgacgt aagaacaagc 411661 cccttctcat tagcgagaag gggtttttct tttcaaaaaa acaccgcaag acatagtctt 411721 gcggtgccgc cttcatggag attacgttta tttagtagcc tcctacaaat gcagttccca 411781 caatgatcaa gaggataaat aacacaacaa tcaaagcgaa agaagttccg taacctgaca 411841 ttttgtgcac ctccttgcga gattgcttca gcaaatgctg caaaactgtg gcggacaggg 411901 tcccgcagag acggtcagca gcttagaagc cgccaacaaa cgcagtccct acgataatta 411961 atagaataaa caatacaacg attaaagcga aagaactgat gccgccgtaa ccgccgccgt 412021 tagagtatcc tgacataagg tttcacctcc ctatgaagga tactataaga tatgctgaac 412081 cgatccattt ggcagggata atagtggaca agagaaaaaa tgaagaattc ggctatatga 412141 aggtgatata aaaaaatagc gggcgctgcc gcccgctatt tatgtacgat taagagatca 412201 gcacgcccgc gaaaaattcc tggtataacg cttgaacggc ttttctttct tcggcttctt 412261 ttacgccaaa catcatgctc acttcagaag acccctgatt gatcatttcg atattcacct 412321 gtgcctctga taatgctttg gcggctcttg ccgttgtacc gacattgtgg cgcatcgctt 412381 cccctacaac cataatcagg gcgagatgat gctcgacgat gacttcatcg gcatgcaaat 412441 cctcttcgat ccgtttgatg acgctgcgtt cagtggcggc atccatttgc ccctgccgta 412501 aaatgattgt catgtcatcg attcccgatg gaacatgctc atacgtcaaa ccatgctcct 412561 ccaggatttg aagggctctg cggccaaaac cgatttctct gttcatgaga tacttgctga 412621 tataaatgct gcaaaaaccg gtgtcgctgg caatgccgac gacaggcccg tttgtgttat 412681 cccgcttgct gacgacgcgg gtgccttcgg ctgaggggtt gttcgtattt ttgatctgaa 412741 caggaatccc cgctctgaat gccggaatga gcgcttcatc atgaaacact gaaaaacccg 412801 cgtaggacag ctcccgcatc tctctatatg tcagctcgct gatttccttt ggattctcaa 412861 cgaaggacgg attgacagaa tacacagcgt ctacgtctgt aaagttttcg tacaaatcgg 412921 cttgtagtcc gttggcaaga atcgaaccgg taatatcaga accgctccgt gagaatgtga 412981 tcacatcgcc atccttgctg aatccgaaaa aaccgggaaa aatgatgagt ccgtcacgtt 413041 cccgaagacg atagaggttt tgataggatt caggaagaac ttgcgcgttg ccgggttcat 413101 ttgtcacaaa gaggccggca tccttcgggt ttacatattc cgctttgacg cctttataac 413161 ggaagtaagc ggcgatcagt ttggcattgt tatcctctcc gctggccttg actgcgtcaa 413221 ggtattgttc gggattgctt ttgtctcctt ctaaaagcgt aaacagatca tctctgattt 413281 tttcgataat gctttgcccc agctgaagct cattggcgat gagagcgtac cgttccacaa 413341 cagcttccgc cagttcaggt gcgctgcctg ttgccaaata ttgttctgca catgcgatta 413401 agagatcagt cactttcgta tcctcggcat agtgttttcc cggagctgaa acgactacag 413461 ctttccgtgc cggatctgag gtaacgatgt gaaacacctt gtcaagctgg gcgcctgaag 413521 caagtgagct gcctccgaat ttaacgacct tcatgtttac atctcctaat gtttaaaatt 413581 ttcacacaaa tttagtattt attatctctc tttcagtact gtaaatcaag ggggaatttc 413641 tttctcagga gaacatttgt atttttcacg aggaataatg ttaggtttgc tgaccgtatg 413701 cctgcgttat aaagataaat atggtaaaca gcctaacgtt ttgggatgga aaatggttag 413761 aatgattagt aaaattgata aatgactagg ttaatatttt taaagaatat tgactaaccc 413821 tataaaaatg gtaatatgta aatgataatg ataatcaatt actatatggc catattgttt 413881 tgagtccttg cggagtagga gatacgttct ttttgctgta aggatgtaag gaggcagcat 413941 gaagctacgt tacttattta ttctacttat catattagca gtcacatctg tatttatcgg 414001 tgtagaagat ctgtcgccgc ttgatctctt cgatttaagc aaacaagagg cgtcaacgct 414061 gtttgcaagc cgtttgccgc gattgatcag cattgtcatt gcgggattaa gcatgagcat 414121 ctgcggtttg attatgcagc agatcagcag aaataaattc gtgtcaccga cgacggcggg 414181 cacgatggat tgggcgaggc tcggcatttt aatttccttg ctgctgttta catccgccag 414241 tcctttaatc aaaatgctgg tcgcgtttgt ctttgccctt gcaggaaatt ttctgtttat 414301 gaaaatcctt gaaagaatca agtttaacga caccatcttt attccgcttg tcggtttaat 414361 gctcgggaat atcgtcagtt caatcgcgac atttatcgca tataaatatg acttgatcca 414421 gaatgtgtca tcatggctgc agggagactt ctctttagtc gtgaaaggaa gatacgagct 414481 tctttatctg agtattccgc tcgtcatcat tgcctatgtg tatgcggata aattcacatt 414541 ggccggtatg ggtgaaagct tttctgtcaa cctcggcctc aagtataaac gggttgtgaa 414601 catcgggctc attatcgtgt ccctgatcac gtctcttgtc attttgactg tcggtatgct 414661 gccgtttctc ggtttaatca tcccgaatat tgtatcgatt tacagaggag acaatctgaa 414721 gagcagcctg ccgcatactg tgctgttggg agcggttttt gtgctgtttt gcgatatact 414781 gggcagaatc attatcttcc cttatgaaat ctcgattggc ctgatggtcg gaatcatcgg 414841 cagcggcatt ttcctgttta tgctgttaag gagaaaagcc tatgcgtaac cagatgaaaa 414901 tagctttgct cgttggttta gccattgtat gtattggctt gtttttgttt tatgacttag 414961 gcaattggga ttacaccctg ccgagacgaa tcaaaaaagt cgctgccatt gtgctgactg 415021 ggggagcgat tgcgttttcg accatgatct ttcaaacgat tacgaacaac cgcatcctga 415081 cgccgagcat tttgggcctt gattctctct acatgctgat tcagactggc attatctttt 415141 tgttcggttc tgcgaatatg gtcatcatga ataaaaacat caactttatc atctctgttc 415201 tgctgatgat cctgttttct cttgttttgt atcagatcat gttcaagggt gaggggagaa 415261 atatcttttt ccttctgctt atcggaatcg tgtttggcac gctgttcagc agcctgtctt 415321 cttttatgca gatgctgatt gatccgaacg agttccaagt tgtgcaggac aagatgtttg 415381 ccagctttaa caatatcaat acggatttgt tatggctcgc gttcatcatc ttcctgctga 415441 caggcgttta tgtctggcgt tttacaaaat ttttcgatgt gctgtcgctc ggacgcgagc 415501 acgccgtgaa tttgggcatt gactacgaca aagtggtgaa gcagatgctg atcgtggttg 415561 cgattttggt ttctgtttca acagcgctag tcgggccgat tatgttttta ggccttctgg 415621 tcgtcaacct ggcgagagaa ttcctgaaaa catataagca ttcatactta atcgcaggct 415681 ccgttttcat cagcatcatt gcgctggtcg gagggcagtt tgtggttgag aaagtgttta 415741 ccttctcaac gacgctgagc gtcattatta attttgccgg cgggatttat tttatctact 415801 tgctgttaaa ggagaataaa tcatggtaga ggtcagaaat gtaagcaaac aatatggcgg 415861 gaaagttgtt cttgaagaga cgtcagtcac gattcaaaag ggcaaaatca cctcgtttat 415921 cggtcctaac ggcgccggca aaagtacgct gctgtctatc atgagccgcc tgatcaaaaa 415981 ggattccggc gagatttaca tagacggaca agagattgga gcatgtgaca gcaaagagct 416041 tgccaagaaa atgagcattt tgaagcaggc gaaccaaatc aatatcaggc tcacgatcaa 416101 agacctcgtc agttttggca ggtttccgta ctcacagggc cggctgacag aggaagactg 416161 ggttcatatc aaccaggcgc ttagctatat gaagctggaa gacattcaag acaaatactt 416221 ggatcagctg agcggcggac agtgccaaag ggcatttatc gccatggtca ttgcccagga 416281 cacagattat atctttctgg atgaaccgct gaacaatctg gatatgaaac actcagttga 416341 aattatgaaa ctgctgaaac ggctggtaga ggagcttgga aaaacgatcg tgatcgtcat 416401 tcacgatatc aattttgctt cagtctattc tgactatatc gtcgctttga aaaacggccg 416461 aatcgttaaa gaaggaccgc ctgaagaaat gatagaaaca tcagtgcttg aggaaatcta 416521 cgatatgacc atcccgattc agacgattga taatcaaaga ataggtgttt atttttctta 416581 atatatagaa gaggtgagga gcatgaaaaa gttcgcgtta ctattcatcg ctttggtcac 416641 tgccgttgtc atttctgcat gcggaaacca aagcacaagc agcaaaggtt ctgatacaaa 416701 gaaagaacaa atcacagtga aacaccagct cgacaaaaac ggcacaaaag taccgaagaa 416761 ccctaaaaaa gttgtcgtat ttgactttgg aagcttagat acattagata aactaggact 416821 tgatgatata gtagcgggcc tgccgaaaca agtccttcct aaatatctgt ccaaattcaa 416881 ggatgacaaa tacgctgatg tcggcagctt aaaagagcca gacttcgaca aagtggcaga 416941 attagatcct gatctgatca ttatttcagc aagacaatct gagtcttaca aagaattctc 417001 taaaattgcg ccgacgattt accttggtgt agatacagcg aagtacatgg aatcatttaa 417061 atcagacgct gaaacaatcg gtaaaatctt tgataaagaa gacaaagtga aagatgagct 417121 cgcaaacatt gatcactcaa tcgcagatgt aaagaaaacc gctgaaaagc ttaacaaaaa 417181 cggtctcgtc atcatggcga acgatggaaa aatcagcgcg ttcggcccta aatcaagata 417241 cggcctgatc catgacgtat tcggcgtggc tccggctgat caaaacatca aagcgtctac 417301 gcacggacaa agtgtttctt acgagtacat ttcaaaaaca aaccctgatt acttgtttgt 417361 tattgaccgc ggtacagcaa tcggagaaac atcatctaca aaacaagtcg tggaaaacga 417421 ttatgtgaaa aacgtaaacg cagtgaaaaa tggtcatgtc atctaccttg attctgctac 417481 ttggtattta tcaggaggcg gacttgagtc tatgacgcaa atgattaaag aagtgaaaga 417541 cggtttagaa aagtaaaacc aaaaagagcc tccgctaaat agcggggctc tttttttgtt 417601 aatcagcgtg ccggctgctg ttcggcaggg cgctgaggtt tctttaatgt gaatgagaga 417661 aggaagccga caagtgcaat gacggcagcc actataaaag cggcgttcat gccgtgcagg 417721 gcggcgtgct tcacatttgt cgtgcctgca tgtgccgcct ggttgctcat cacggaaacc 417781 aatagtgcgg ttccgatcga gccgccgact tggcgaatcg tgttgttcat cgcagttccg 417841 tgcggaatca agtggcgcgg cagcgcattg attccggctg ttgtcaccgg catcatgatc 417901 atggcggtgc ctaagagacg aacggtgtat aaaacgacaa tccaagcgag tgacgtatgg 417961 tcagtcagct gcataaacgg cagagatgtc aggaagatga tgcagaaacc ggcaatcgcc 418021 agccctcttc cgccgacacg gtcaaaaatt ctgccgataa tcggcgacat aaagcccatc 418081 acaacggctc ccggcaggag cataagccct gtatcaaaag ctgtgacgtc tctgacattt 418141 tgtgtataaa gcggcaggat ggtttccgta ccgatcaata atgcaaagac gagggttccc 418201 agcagtgttg ttaagctgaa aacgccaaac gtgaagacgc ggaattccag catcggtttt 418261 ttaagcttca tttgtcttgt gataaacaag agcagcgcga tgacacccac cagcagtgaa 418321 atcaagacgg ttgaactgga ccagccataa gagccgacgc ttgagaagcc gtacagaagg 418381 ccgccgaacc caaatgttga aaggatgact gataaaatat caatctgtgt ttttcttaaa 418441 gtcgtcacgt ttttcatcag gatgctggca agaatcaaat caatcacagc aaacggaaga 418501 ataatataaa acaatgatct ccaagagaaa gcttcgacag cccatccgga aagagtcggt 418561 ccgatcgcag gcgcgaatga gatgaccaat ccgaccatac ccatagcctg gccgcgcttt 418621 tcaatcggaa agattgtcag gaatacagtc tgcatgagcg gcatcataat gccggctcca 418681 gccgcttgaa tgatacgcgc tgtcagcaga accgggaagt tcggcgcgaa cgctccgacg 418741 actgttccgg cagtgaaaat gctcattgct gtgatgagca gcgcccggct tgtgaatttc 418801 tcaattaaaa acgcggtaat cggaattaaa atcccgttgg ttaacataaa tgatgttgtc 418861 agccattgtg cttggttggc atcgacattg aaatccctca tgatatgggg aagtgcagta 418921 atcaacaatg tctggttcaa aatcgccaca aacgctccgg ctaacaaaat gccgacaatg 418981 acagaacggt taaaaggttt ttgttcaata cttgtgttca atacatatcc cttcttttct 419041 ctaagtaatt aacagtgttt ttaacatgga aacgggctgt gttaaaacac cggtttgttc 419101 cagatagcca atcagtgatt tgagtaaaaa agcgcggggt tcttccttct tcgcttcttc 419161 ctccagcata gcggctgcgg atgtcagttc atctacgtca tagtccgcgg cggacaggga 419221 agagatgcct ttatgtaatt ccttcaggct ttccgataat aggactgatt tatcctttgg 419281 cttgtaggag gatgctgaat gaatataaag ctcgatggct tcgggcggaa gaagagactg 419341 gcgggtttcc ctgtttttga taatctgatt gagggtgctg atgataaact ctgcgatcgg 419401 gtcaagctca agcggttttt cctcgatttt gatcagcatt aaaaactcac gcatcatgcc 419461 gtgaagaatg ataaccaaat cccacacaaa cgggagaatg gtttctccat acgcctggat 419521 cagcgaatcg cggtgccagc agataatcgt cgatctggtc tgatggatat gctgtttgac 419581 ccggtcattg tgcagcttgg ggtttccgta ggtcagcata ttgaaaaact gctgattccg 419641 cctgaagccc tccagttcca ttttgacctt ttgcgtcaaa cgctcctccg gtgtaagtgc 419701 tgtattttcc tgaagtcttg aggccgcggc caccatttgc ttctggttaa atgacagcag 419761 ctccaaaagc agatcttctt tagattggaa cagcttatat atcgaagctt ttgacatctt 419821 acattcttct gcgatcgcct gcatggaaac cgacgtaaaa tccttttccg aaaaaagctt 419881 tcgcgcggct aacaagatat ctgttttttt atcaagcatc tcatggcttc cttctttctt 419941 gaacattaga aaacccattg gttcacagaa aaccaatgag taacaatgaa aaaattttac 420001 cagataaaca aaatagaagt caatggattt taaccgggta aatgaaaggc ctgccggaaa 420061 atccgacagg ccgaataaga gcttattttt caactttaaa tccttgtttt tcaagcattt 420121 cacggatgtg cggatagtac aggcgctcat agtaggaagc gatgctctgt gaccagtttc 420181 ttgtttcttt tccgtttgtc cgtttattca tgtattcaga catctgttcg tcgtatgcct 420241 gaatgtgaga cgtcagctca tcctgattca aataagtttc ctgatgattg acagcttcct 420301 gcggcaagcg cggttttttc gctgaacggt cggcaggatg cccaatgaca aggccggata 420361 aagggaacac gtatttcgga agctcaagca gttcgatcag ctcttgaggg tttccgcgaa 420421 ctgcaccgat cggaactgtg ccaagtccga gtgactcagc cgctgctgtt gctgtgccga 420481 gggcaatacc agcgtctact gcgccgacaa gaacagattc caatccattt gtgatttcca 420541 ttttgaaatc atgcagatct tcaagcgcaa ttttggcccg gttaaaatct gcgcagaaca 420601 gcaggaaaac aggagcttga tcgatccatg gctggccgcc tgccagctcg gagattttct 420661 ttttgcgctc tttatcctgg actgtgatca cagtcacttg ctgtccgttg atagaagaag 420721 gggctgattg caccgcttca atgatttggt ccaattgctc ctgagctaca ggctcatctg 420781 tgtagctgcg aatcgagcgg tggtctgtta aagatttaat cacttcattc atatgagaca 420841 cccttccttt actcgctaag ctctgtgcgg acaacatcaa gaggagcgct cagcagttct 420901 tttccttttg cgacaaaccc ttggaaatgc gcagtttcgt tatggaattt cattgccgct 420961 tcatctttcc atttttcaag catgacaaat gtattttctt cgcctacttt ttcgaatagg 421021 tcgtattgcg cgttgccttc ctcagctctt gaatgctgaa caagtgattg agcctcgctc 421081 aaaaattcct cgcgtttttc tggttttact ttgatgtaag cttgtaatac gatcatgtaa 421141 atctcctccg tcgttatgcg aatttattgt tcgaatttca tcgaactaaa tgtaacatgt 421201 attctaaatg aggtaaagga aaaaccctta tatagtaaaa ttgtcattct aattgttgta 421261 tgatacattt gtgtcatgaa cattccaaac catccagaaa cagaaacatt gcagctgaca 421321 aaggttcttc atgcacttag tgatccgctt cgtttagagc tcgtcaagca attagctgaa 421381 gcaaaagaaa aaacgtgcag cacctgtgca gatgtgcagg ttgccaaatc gactttgtcg 421441 catcatttta aagttttgag agaatcaggc atcgctcaag ttcggataga aggaaagcgc 421501 cggtattatt cgcttcgcgc tgaagacctt gaaaaggcat ttccgggact gcttgaagcc 421561 gtgctgaatg tagaccagga ccgctggtga atcaatcccc tgtaacgggg atttttttat 421621 gtccgtaaac cgctttgaaa agccgctgca caccctcctg aatatcttct tccttcagcc 421681 gtgcaaagcc gataatgaga gcaggcctgc ccgtttgccg cttgttttcc ttcaagttaa 421741 atcggctcat tccgaatatt tcaagctgca gcccggcagc atgtgacagg atgtcttgtt 421801 cggtgcgcct ggtatcaaat tcggtaacaa aatgcagccc cgcatttgcc ccttttacgg 421861 taacctctcc gctgaactct gcttctaaag cggtgatcag gcgttctctc ttttctttat 421921 aatgctgctt catttttttt atatgcttct gatattcacc agactcgata aattcctgca 421981 gggtgagctg tgtgagtgat gagcaagtct gcagatcata gccccgctgt ttgtatgccc 422041 tcaacagctc aggcggcaac accatatagc tgatccgtaa gccggggaga agggactttg 422101 aaaaggttcc catatagatg acattttgaa aacggtcgag gctttgcagc gccggaatac 422161 tgtctacatc atatgtgaat tcactatcat aatcgtcctc aatgatatat cggcgcggct 422221 cctcggctgc ccagttcagc agctgaattc ttctggatac aggcataatc gttccggacg 422281 gaaactgatg cgacggggtg gtcaccagca catctggctg ctgtctggtg atttcagcaa 422341 tcgacatgcc tttttcatcc agcatgatcg tctttacttg ttttccggca ttcttcaaaa 422401 gctgatacat gcgcctgtag ccaggctcct ccatcgcata cacggcttcc ttgggtaaaa 422461 gctcagtcaa cagctgcatg agcacctgtg tgcctgcccc tatgatcatt tgttccggcc 422521 tgcattttac acccctcgtc agggaaatga gcctcgtaat ggccgctctc acttcatata 422581 tcccttgcgg atgtgacata tcgccgagcg tgcggtatga gcgggaggcc gctttttgct 422641 cgcagcggaa ccagcttttg atcggaaaat ggtctgtatc ggaactcatg tgtgaaaacg 422701 atatccaatc gctctggtcg atgtgaatct cttttaggtc atccggcagt gcaaatggag 422761 ggtgctcctc ggcggaaaac atgtctagtt cctccacgaa gaaacccttt cgttcaatgg 422821 cgtacaaata cccctcagcc agcagctgct gataggctga attcactgaa tttacgctga 422881 ccttgagatt ttcagccagc tcccgcttgg agggaacctt cgagtgcggc agcagattgc 422941 ggctgaggat ttcttttttc agcttttgat aaatttgctg atagatataa tcggcttgtt 423001 ctgaacgatc gagtgtaatc gtgatatcca ttttgtagtt tctccttctg ataccatcaa 423061 aaagttataa ttggtacttt tcatcatacc aaagagaagt cagaatgata agaaaatacc 423121 gacaggggga tattcacatg agtcaaacaa cagcaagcat cacaactgca caatggcagc 423181 aaaaacggga tcaatttgtg tcaaaaggtg tgagcaacgg caaccgcagt ctggcggtca 423241 aaggagaagg ggccgagctg tacgatctgg atggccggag atttattgat tttgcaggcg 423301 ccatcggcac gttaaatgtc ggacactcgc atccgaaggt ggttgaggct gtgaagcggc 423361 aggcggagga gctgattcat cctggtttta atgtcatgat gtacccgact tatatcgaat 423421 tagcagaaaa actgtgcggc atcgcgccgg gcagccatga gaaaaaagcg atttttctta 423481 actcaggggc agaagcggtc gaaaacgctg tgaaaatcgc cagaaagtat acaaagcgcc 423541 aaggcgttgt ctcgtttaca cgcgggtttc acgggcgcac gaatatgacg atgagcatga 423601 caagcaaggt aaaaccttat aaattcggtt tcgggccttt tgcgccagag gtttatcaag 423661 cgccgttccc ttattattat cagaagccgg ccggcatgag tgatgaaagc tatgacgata 423721 tggtcattca agcattcaat gatttcttta tcgcttcagt ggcgcctgaa acggtggcgt 423781 gtgtcgtgat ggagccagtg cagggagaag gcggatttat tattccttcg aaacggttcg 423841 tacagcacgt cgcttcattc tgcaaagaac acggcattgt ttttgttgct gatgaaatcc 423901 aaaccggctt tgccagaact ggcacttatt tcgcaattga gcactttgat gtagtgcccg 423961 atctgatcac ggtttctaaa tcgcttgcgg caggcctgcc attaagcggt gtgatcgggc 424021 gtgcggaaat gcttgatgcg gcagcgccag gggagctggg cggcacgtat gccggcagcc 424081 cgctcggctg cgcggcggct ttggcagtct tggatattat cgaagaagaa ggactgaatg 424141 agcgatctga agaaattggc aaaatcattg aagacaaggc gtatgagtgg aaacaagaat 424201 tcccgttcat cggtgacatc cgcagactcg gggcgatggc cgcaatcgaa atcgtcaagg 424261 atcctgacac gcgtgagcct gataagacaa aagcagcagc gatcgcggcc tatgcgaatc 424321 aaaacggatt acttttgctg acagcgggaa ttaacggtaa tatcatccgc tttttgacac 424381 cgctcgtcat ctcagacagc ctattaaatg aagggctcag catcttggag gcgggcctgc 424441 gagcttaatc attggaaaga aaatggccgg gtctgctatc attttaagta atcatgaaaa 424501 gaaaggaatg ttcaatatgc cagatcaatt aacggtctac aacccggcta cgggcgagga 424561 gatcaaaacg attcctcagc aatcagccac agaggtagaa gaagccattg aacgttcaca 424621 tcaagcgttt aaaacgtggt ctaaaacatc agcgaacgaa agaacgtctc ttttgaaaaa 424681 atggtatgag ctgattgttg aacataaaga agagcttgca gatttaatta caaaggaaaa 424741 cggaaaacca taccaggaag cagtcggcga ggtactttac ggcgcaggct atatcgaatg 424801 gttcgcagag gaagcgaagc gtgtgtacgg aagaacggtc ccggccccga caactggtaa 424861 acgaattgtt gtcacacgcc agccggtcgg ccccgttgct gctatcacgc cctggaattt 424921 cccgaatgcg atgattacac gcaaagcggc gcctgctctt gccgccggct gtacatttat 424981 catcaagccg gcgccggaca caccgctgtc tgcttatgaa ctagcgcgcc tcgcatatga 425041 agcgggcatt ccgaaggatg ttcttcaggt tgtgatcggc gatggagaag aaatcggaaa 425101 tgtgttcaca agcagtccga aaatccgcaa aatcacgttc acaggctcaa cacctgtagg 425161 gaaaatcctt atgaaaaaca gcgctgacac cgtaaagcac gtctcaatgg agctcggcgg 425221 acacgccccg ctgatcgtag atgaagatgc ggacattgac cttgccgttg aacaggcgat 425281 ggcgtccaaa taccgaaacg ccggccaaac ctgcgtatgt gccaaccgcc tgatcgttca 425341 tgaatccatt aaagatgaat ttgctgcgaa actgagcgag caagtgtcta agctgaaagt 425401 cggaaatgga cttgaggaag gcgtcaatgt cggcccgatt atcaacaaac gaggcttcga 425461 aaaaatcgtc agccaaatag atgatgcggt tgaaaaaggc gcgaaagtga ttgctggggg 425521 cacatatgac cgaaacgatg acaaagggtg ctactttgtg aatccgacag tgctcaccga 425581 tgtcgatacg tccatgaaca tcatgcatga ggaaacattc ggcccggtcg ccccgatcgt 425641 cacgttttct gatattgatg aagcgattca gcttgccaac gatacaccgt atggcttggc 425701 tgcttacttc ttcacagaaa actaccgccg cggcatctat atttccgaga atctagagta 425761 tggcattatc ggctggaatg acggcggacc gtcagcggtt caagcgccat tcggcggaat 425821 gaaagaaagc ggcatcggcc gtgaaggcgg ttcagaaggt atcgagccgt accttgaaac 425881 aaaatatttg tccatcggtt tataaaagaa tgcacgctcc tgagagctgc cggattttcc 425941 ggcagctctt tttgtgttcc ggcgaataat cacaacaatt ccagccaaaa taacagcaaa 426001 tacattttga aagaaggttc cccaacaatg gatttattat tggctcttct cccggctttg 426061 ttttggggga gcattgttct cttcaatgtg aaattaggcg gcgggccgta cagccagaca 426121 ctgggaacga cgatcggggc actcattgtt tctatcgtta tttacttttt tgttcagccc 426181 gttctgtccc ttcgcatttt tattgttgga atcgtatccg gcttattttg gtcacttgga 426241 caggccaacc agttgaaaag cattcaattg atgggcgtgt cgaaaacaat gccgatttcc 426301 acaggaatgc agctcgtttc cacctcgctg ttcggtgtga tcgtgttccg cgaatggtca 426361 acaccgattg cgattacgct tggcgttctc gctttgatct ttatcattgt gggaatcatt 426421 ctcacgtcct tggaagataa gaatgataaa aaagagggcg agccaagcaa tttgaaaaag 426481 ggcattttga ttctccttgt ttcgactctt ggttatttgg tttatgtagt cgtggctaga 426541 ttattcaatg tgtccggctg gtccgcgctg ctgccacagg caattggcat ggtggtcggg 426601 gggttagttt taacctatag acacaaaccc tttaacaagt atgcgatcag aaatattctc 426661 ccagggttaa tctgggcagg cggaaatatg tttttgttta tttctcagcc gcgagtcggc 426721 gttgcaacga gcttttccct ttcacaaatg ggaattgtca tttctacgct cggcggtatt 426781 ttcatcctgc gtgaaaagaa aacgaaacgc cagctaatag caattgcgat cgggattatc 426841 ctgattattg ccgccgccgt attcttagga atcgccaaaa caaattcata acaaatggag 426901 gaggatgtat atgtatccgg atttaaaagg aaaagtcgtc gctattacag gagctgcttc 426961 agggctcgga aaggcgatgg ccattcgctt cggcaaggag caggcaaaag tggttatcaa 427021 ctattatagt aataaacaag atccgaacga ggtaaaagaa gaggtcatca aggcgggcgg 427081 tgaagctgtt gtcgtccaag gagatgtcac gaaagaggaa gatgtaaaaa atatcgtgca 427141 aacggcaatt aaggagttcg gcacactcga tattatgatt aataatgccg gtcttgaaaa 427201 tcctgtgcca tctcacgaaa tgccgctcaa ggattgggat aaagtcatcg gcacgaactt 427261 aacgggtgcc tttttaggaa gccgtgaagc gattaaatat ttcgtagaaa acgatatcaa 427321 gggaaatgtc attaacatgt ccagtgtgca cgaagtgatt ccttggccgt tatttgtcca 427381 ctatgcggca agtaaaggcg ggataaagct gatgacagaa acattagcgt tggaatacgc 427441 gccgaagggc attcgcgtca ataatattgg gccaggtgcg atcaacacgc caatcaatgc 427501 tgaaaaattc gctgacccta aacagaaagc tgatgtagaa agcatgattc caatgggata 427561 tatcggcgaa ccggaggaga tcgccgcagt agcagcctgg cttgcttcga aggaagccag 427621 ctacgtcaca ggcatcacgt tattcgcgga cggcggtatg acacaatatc cttcattcca 427681 ggcaggccgc ggttaaacat aaaaagcgac ccagacatga catctggatc gctttcttta 427741 ttaggcacgc tttttcttta caagtgctgc tacagataaa ataatggcag ccgcagacag 427801 caccatcgct gtaatgtcta gagctgaaga acctgagttt tcggaatcgt cttctgtttt 427861 cgtggcgccg tgctcatctg tcacttgctt tgcagacgtg atgtttgtaa tggaatgagg 427921 tgtatcggca tcctcgtcac ctgtccactc aacaatgctg ccgtctttgt aatattggta 427981 tgcgtcccaa gcagcttcct ccgctttgtc agggtttttg gcaacaaagg taaactgctg 428041 gaactggcct tcctgaatgc ctccgtcagt cgcctcccat gtcacggata ctgatttgtc 428101 atcatgtttt tgagtggaaa ccttccagcc cggaattggc tcatattgct ggaattcaac 428161 atccttcggc attttgagga caaccttcgt tgtcggcaga tttttctcag aaggaacctt 428221 cattgtatac gtttcccaag agcctgcagc agactcagcc ggttttacag aaacatgcgc 428281 gctggcaggg gccgtaaaga ataagaggga gccgacaata gccggacata gtgtcaatgc 428341 gatttttttc aacaacgtaa acactcctta attggtcttt gtaaacatga tattgatttc 428401 gttaaagtcg ccggtcaggc cgtggacttt gatcttccag tttccttttt cattaatcga 428461 caggttttga tcttggaaga cgccttttgt tttttctttt aatgtaaagg tgcttttgtt 428521 ttcgctgcct gacaggcctg ttttataaac ggttaacgtg atttgctgga tgtttttcac 428581 gggatcaccg ttatggtcgg tgacccgcag ctcaaaaaca ttttttccag gctggtttgg 428641 gctgatgctg agagaaacgc tttgtccgtt ctctatcgct ttggtttggt agaacggttc 428701 cggcgctggc tcaggcgggc ttggcaggct tgtaaacacg gccgctgtga tcaatacagc 428761 gatgccgatt gcccactccg ctttcaacgt tcggctgatt cctgtgcggc gctgctttct 428821 ggtaagcaga aaatgaattg cgcctaagac cagcatgaaa acaaacagcc cgcttttcac 428881 taaaagagct tgtccgtacg ctgtatggaa cagtgaatcc attgaacgaa tgatgaaaaa 428941 tccattgagc aagcctgaaa acaaaatgac gccgactgca gtgagcgccc atggggagaa 429001 ccgtctgacc gtctcccacg cgagcgtttt gtcaggctgc ctccattctt ttgagagcag 429061 caaaacgagt gccgctattc cgccgaccca gatggaagcg gaagttaaat gaaggaaatc 429121 catcaaaatg ccgaccgttt tttcttcaac gacagcagca tgcccggtaa acgccttggc 429181 aagcaggaga ccgaaaaaga aaatgagcgg cgctgtccaa tagccaaagg atgaaaagcg 429241 gtttttccgt atcgcaggga tgacagacag tgcgagcagc acgaacagcg cagcctgtat 429301 gatccaaatg gagccgcctg ctgtctcaaa cagtgtttct ctgatgtagc ccggctggaa 429361 tgcgctgccc cagccgccgc ctgcgttcgc ttttgtctga atcggaagct gaagcaaaag 429421 cgccagcccc aatgctgcga tcgagccggt caggatacgt ctcgtccgtt tgacgagctg 429481 ttctgatttc cctttatacc agaaaagatg gaagaaaacc gttccgataa acagagataa 429541 ggctgtatac agaatcgcgc gatctgctgc tgttcccgga ttcagcgctg aatcggctgc 429601 tttttggctg ctgaatccgc catccgcttt cccgatactg aacggaatga cgccggaaac 429661 aggatgtcca tccgcggata cggcattcca ttccgctctg tacacatctt taggcagatt 429721 cttcttcagc ttcactgtca tgatgtgatg attatctttt ttgatttcag tcttgtccgt 429781 atccacacgg tcgccgtttg aattatagac tttaatgtaa tgaaaccctt cttcaaccgg 429841 ttcattaaat tcgatttcca cctgcgcagg ggcgcttttt aattcgctgt tttccccagg 429901 tgaagatttg acaatatagg cgtgagcaaa gcttgttttc ggcaggaaaa caagaaaaag 429961 cagaaggatg atccaccatc tgtttcgctt catcactcag acaccacctt ccgctgtatg 430021 tgttgtgtta tttcttggtg caggtgcagc gtttctttcg gtcttgaagc atgtcttcca 430081 gcgcttggtc gaaagtgcag acggctccgc cgaatccttt ttgaaatcgt tcggcatggt 430141 caagtgtcgc aaacggaatg gcctgcggct ggcagcagtg caggtttaat tcagcattta 430201 cgacgaaata agccgaaccg gcactgacgg ttgtctgtaa cagaaaatct ctgcaaatca 430261 agtgtgaaac ctcttccgtt ttatccgcgt aacgcaaaaa cgcgcaatgt gcgcagcata 430321 gctgttcaat gtcttggttt accgtaatca gctgaaccga atgagcttga ttgacgggct 430381 tcaagcaata gctgcacata tgatctgttt gaggtgttcg gacggggagc gtgatgccgc 430441 cggccgtttt aatgacctga tttgactgaa ccagctgatt gacatctcta tataccgtca 430501 tttccgaaac gccgaacctt gcgctgatgt cagaaattct aagcgagcct tcttctttca 430561 gccacttcag tatgtgttgc tgtctattaa tcggaagcat tcatacaccc tcttcattaa 430621 gatctattta agcgtagagg attttagaga cggagacaag taagtggatg ataaaaaatg 430681 tgaaaatgtg ttgaacagca acaaaacgaa acagaaggga ctctggtata atagacagat 430741 ggaatagaaa gtgaggaata ccctatgaaa gaaacaccat gcccgaactg cggcaaacct 430801 ttgacaggcg atatggtcag atcatcaaat gtgccttgtc aatttcgctg cggccactgc 430861 cgggaacggc tttatgaata taaagtttca gctccgatta tgctggtatc attagcggcc 430921 atcgtgctgc ttatttatct tttgatgctc ctccgcaatg cggcaggctc agtgctgcca 430981 gctgtacagc acgtgccgat ggctgtattt gcgcttgtgt gcgcgtatcc cgtttttatt 431041 gtgagtgagc ggatgattgc aaagtacgtg attcaaaatg gcaacatcat ttatagagga 431101 aagagaaaag gctcctgaaa ccaggagcct ttttattttt aaaaaattgt cacagtcatg 431161 tgccaaagtc ctctttactt tcaattgtat agggactgta agcgttttaa catagagtca 431221 aagggaagca tcattctctg aacatatttt tgtatcttac agcgacaaac aaaacaggga 431281 gggtttatat atgcagcagc aagaacagca gcaaggcggc atgaaagtga aagtgcaacg 431341 ctttgggagt tatttgagcg gaatgatcat gccgaatatc ggcgcgttta tcgcgtgggg 431401 tatcattacc gcgctgttta ttccggcagg atggtttccg aatgaacagc tgaacacgct 431461 ggtcagcccg atgattacgt atttattgcc gcttttgata gcgtatacag gcggaaaaat 431521 gatctacgac caccgcggcg gagttgtcgg agcgacagcg gcaattgggg tgattgtagg 431581 atcggatatt ccaatgtttt taggcgcaat gattatgggt ccgcttggcg gatacctcat 431641 taaacagact gataaattat tcaaggataa agtcaagcaa ggctttgaaa tgctgatcaa 431701 caactttacg gcagggattg tcggcgcggc tttaacgatt ctcgcgtttt acgccatcgg 431761 cccggttgtc ttgacgctaa ataaattgct ggcggctggt gtggaagtca ttgtacacgc 431821 taatttactg ccggtagcca gtgtttttgt agaaccggcg aaagtgttgt tccttaacaa 431881 cgccataaac catggaatct taagcccgat cggaatcgag caagcatctc aaacaggaaa 431941 atcaattctg tttttagtag aagcaaaccc tggaccgggg ctcggcattt tgctggccta 432001 catgttcttt ggcaaaggat cttcaaaatc aacggctccc ggtgcggcga tcatccattt 432061 cttcggaggg attcacgaga tttacttccc gtacattctg atgaaaccgg ccctgattct 432121 cgcagccatt gccggcggag caagcggact cttaacattt acgatcttta atgccggact 432181 tgtcgcggca gcgtcaccgg gaagcattat cgcattgatg gcaatgacgc caagaggagg 432241 ctatttcggc gtattggcgg gtgtattggt cgctgcagct gtatcgttca tcgtttcagc 432301 agtgatcctg aaatcctcta aagctagtga agaagacctg gctgccgcaa cagaaaaaat 432361 gcagtccatg aaggggaaga aaagccaagc agcagctgct ttagaggcgg aacaagccaa 432421 agcagaagaa gcgtctgagc tgtctcctga aagcgtgaac aaaattatct ttgcgtgtga 432481 tgcgggaatg ggatcaagtg ccatgggggc atccatctta agaaacaaag tgaaaaaagc 432541 ggagcttgac atcagtgtga ccaacacggc cattaacaat ctgccaagcg atgcggatat 432601 tgtcatcacc cacaaagatt taacagaccg cgcgaaagca aagctgccga acgcgacgca 432661 catatcagtg gataacttct taaacagccc gaaatacgac gagctgattg aaaagctgaa 432721 aaagtaatct tatagaaaga gagtgattgt catgcaagta ctcgcaaagg aaaacattaa 432781 actcaatcaa acggtatcat caaaagaaga ggctatcaaa ttggcaggcc agacgctgat 432841 tgacaacggc tacgtgacag aggattacat tagcaaaatg tttgaacgtg aagaaacgtc 432901 ttctacgttt atggggaatt tcattgccat tccacacggc acagaagaag cgaaaagcga 432961 ggtgcttcac tcaggaattt caatcataca gattccagag ggcgttgagt acggagaagg 433021 caacacggca aaagtggtat tcggcattgc gggtaaaaat aatgagcatt tagacatttt 433081 gtctaacatc gccattatct gttcagaaga agaaaacatt gaacgcctga tctccgctaa 433141 aagcgaagaa gatttgatcg ccattttcaa cgaggtgaac tgacatgatc gccttacatt 433201 tcggtgcggg aaatatcggg agaggattta tcggcgcgct gcttcaccac tccggctatg 433261 atgtggtgtt tgcggatgtg aacgaaacga tggtcagcct cctcaatgaa aaaaaagaat 433321 acacagtgga actggcggaa gagggacgtt catcggagat cattggcccg gtgagcgcta 433381 ttaacagcgg cagtcagacc gaggagctgt accggctgat gaatgaggcg gcgctcatca 433441 caacagctgt cggcccgaat gtgctgaagc tgattgcccc gtctatcgca gaaggtttaa 433501 gacgaagaaa tactgcaaac acactgaata tcattgcctg cgaaaatatg attggcggaa 433561 gcagcttctt aaagaaagaa atatacagcc atttaacgga agcagagcag aaatccgtca 433621 gtgaaacggt aggttttccg aattctgccg ttgaccggat cgtcccgatt cagcatcatg 433681 aagacccgct gaaagtatcg gttgaaccat ttttcgaatg ggtcattgat gaatcaggct 433741 ttaaagggaa aacaccagtc ataaacggcg cactgtttgt tgatgattta acgccgtaca 433801 tcgaacggaa gctgtttacg gtcaataccg gacacgcggt cacagcgtat gtcggctatc 433861 agcgcggact caaaacggtc aaagaagcaa ttgatcatcc ggaaatccgc cgtgttgttc 433921 attcggcgct gcttgaaact ggtgactatc tcgtcaaatc gtatggcttt aagcaaactg 433981 aacacgaaca atatatcaaa aaaatcatcg gtcgctttga aaatcctttc atttcggacg 434041 atgtgacccg cgtagcgagg tcacctctca gaaaactggg agaaaatgat agacttgtag 434101 gcccggcaaa gaaaataaaa gaaccgaatg cactggctga aggaattgcc gcagcactgc 434161 gcttcgattt caccggtgac cctgaagcgg ttgaactgca agcgctgatc gaagaaaaag 434221 gatacagcgg cgtacttcaa gaggtgtgcg gcattcagtc ccatgaaccg ttgcacgcca 434281 tcattttaaa gaaacttaat caataaccga ccacccgtga cacaatgtca cgggcttttt 434341 ttactatctc gcaatctagt ataatagaaa gcgcttacga taacagggga aggagaatga 434401 cgatgaaaca atttgagatt gcggcaatac cgggagacgg agtaggaaaa gaggttgtag 434461 cggctgctga gaaagtgctt catacagcgg ctgaggtaca cggaggtttg tcattctcat 434521 tcacagcttt tccatggagc tgtgattatt acttggagca cggcaaaatg atgcccgaag 434581 atggaataca tacgcttact caatttgaag cagttttttt gggagctgtc ggaaatccga 434641 agctggttcc cgatcatata tcgttatggg ggctgctgct gaaaatccgg agggagcttg 434701 agctttccat taatatgaga cccgccaaac aaatggcagg cattacgtcg ccgcttctgc 434761 atccaaatga ttttgacttc gtggtgattc gcgagaacag tgaaggtgaa tacagtgaag 434821 ttggcgggcg cattcacaga ggcgatgatg aaatcgccat ccagaatgcc gtgtttacga 434881 gaaaagcgac agaacgtgtc atgcgctttg ccttcgaatt ggcgaaaaaa cggcgcagcc 434941 atgtgacaag cgccacaaag tctaacggca tttatcacgc gatgccgttt tgggatgaag 435001 tctttcagca gacagccgct gattatagcg gaatcgaaac atcatctcag catattgatg 435061 cgctggccgc tttttttgtg acgcgtccgg aaacgtttga tgtcattgtg gcgagcaact 435121 tgttcggtga tattttaacc gacatcagct caagcctgat gggaagcatc ggcattgcgc 435181 cttctgcgaa catcaatcca tccggcaaat atccgtccat gtttgaaccg gttcacggct 435241 cagctcctga cattgccgga cagggccttg ccaatccgat cggccagatt tggacagcga 435301 agctgatgct cgaccacttc ggagaggaag aattgggggc gaaaattctg gatgtaatgg 435361 agcaagtgac tgccgacggc atcaaaacac gcgacattgg gggacaaagc acaacggctg 435421 aggtcactga tgaaatctgt tcgcgcttaa gaaagctctg atgaatcagg ccggtggcag 435481 atggctgccc cggcctgtcc atttccttac gaaaatttcc acgaaagtct aaccaagcag 435541 atccaaatgc tgtataataa tttggaattc ttaggaaagc atcgggtgaa ggaagttgaa 435601 tgcaaaaaca atcacgttaa agaaaaaaag aaaaatcaaa acgatcgttg tactcagtat 435661 cattatgatc gcagctctca tttttacgat cagattggtg ttttacaagc cttttcttat 435721 tgaaggatca tcaatggccc caacgcttaa agactcagaa agaattctgg ttgataaagc 435781 agtcaaatgg actggcgggt ttcacagagg agacatcata gtcattcatg acaaaaagag 435841 cggccgctca tttgtcaaac gtttaatcgg tttgcctggt gacagcatta aaatgaaaaa 435901 tgatcagcta tacataaatg ataaaaaggt ggaagaacca tacttaaagg aatataaaca 435961 ggaggtcaaa gagtcgggtg taaccttaac aggtgacttc gaagttgagg ttccttccgg 436021 taaatatttt gtgatgggag ataaccgtct caattcactg gatagcagaa acggaatggg 436081 catgccttct gaggacgata tcatcggtac tgaatctctc gtcttttatc cattcggtga 436141 gatgagacag gcaaaataaa atgcaatgca aaaagaacat ggaacatgac ggcaccgata 436201 ataaagcgcc gtgcacgttt aaaaaaatga tgatgaaacg gtgcggagcc ggctttccgc 436261 cccgtttttt atgatagaaa gcgttttgaa gaaaagggcc ctgttgaaat aaacagaatc 436321 aggattggcg aagccgtgaa gcgcatcgaa ttggtaaatc tcaagatggg tatgctgttt 436381 ttcccgcagt tttttgataa gaagcgctac gtcaaacgac ggctcataat tagggaaaaa 436441 caataggacc gggcaggctg gcatgtgatg aagagagtcg cgtatccggg aaccgtaata 436501 acaaaccgat ccgctcacct caggcatact gctgcatttc catgcgatag tagcccccac 436561 gctgaatcca atcacaaaga tgtgccgtcc ggcgttttgc ctgatcacat tctggatgat 436621 ggtttctccc gttttcagcc tttcgtgttt tgtaaattgt tcgtatgccg ttttttcttc 436681 tttcagtgtg tagacttcat cctcgccgag caggttgggc gtcaacacat catatccagc 436741 cattttgatc agccggccca tctttttcat atggctgttt acaccatata tttcgtgtgc 436801 gagaatgaca agcggttttg ggaacataac ggcctccttt tgtgtttttt ccattatatc 436861 ctatcgtttc actttaggct gagatataat ggtcaaaaaa aggagatata aaatgaactc 436921 attatctttg cctcaccgct atccattttt gtttattgat ggcgtgacgg atagcgagcc 436981 cggcaaacat gcggcagctt ataagctgat tagtgagaac gactggttta tcactgatac 437041 gcaaacagaa atgccgtttt cacttgtgat tgaagcgctt gcgcaaaccg cggcttttac 437101 aggaattaca gatgagaaca gcttgggatt attgtcttcg gtgaagaaag cggaaaagct 437161 gggagaagct gtgcctggtg accggcttga tcttacgttt gaagtcacgc gcaatcggcg 437221 cgggtttgtg ttcggacatg ccaaggcatc agttggagag cagcctgttg ctgaagctga 437281 aatcggcatc tatattgaaa aatgaaaaaa acccttcaca acattttgtg aggggttcta 437341 ttttgtgtcg taatcccgtt cgctttgaga gttatctctt tgctggcgtt tgtgtttttc 437401 atcattcata ttttccttca gctcttcatt aggaatcgga tcggttaagt cgttgtgctc 437461 ggggttttca tttggtttgt tttgctgttt tttttctgtc atgtttgatc acctcaccgt 437521 ttgttttcct cttattcatt ctcctcaaac ataggaaatc gcttttttgt cccgctgggt 437581 ataatgtatt agaatagaga gaagcacaac aaaaagataa agagaggtac atatatgtct 437641 gttcaaagag aagatgtaga tatcaagctg atcgcaattg atatggatgg tacactgctg 437701 aacgacgagc agctgatctc ggatgaaaac cgcaaagcca ttcgtgaagc ggaggataaa 437761 ggtgtgtatg tggtgatcag cacgggccgg acgctgatga cgtgcaggga gctggcggaa 437821 tcgctaaagc tgtcatcctt tctaatcacg gcaaacggca gtgaaatttg ggattcgaat 437881 tttaatttgg tggaacggaa gctgcttcat acggaccata ttcaaatgat gtgggatttg 437941 cggaataagc acaacactaa tttctgggct tctacggtga ataaagtatg gagaggcgag 438001 tttccggaaa acattacgga tcatgaatgg ctcaaattcg gctttgacat cgaggatgac 438061 gatatccgaa acgaagtgct tgaggagctg agaaaaaaca aagagctcga aatcacaaat 438121 tcaagtccga caaacattga agtcaacgcg cttggcatca acaaagctgc agcccttgcc 438181 aaggttacgg aaaaactcgg ctttacaatg gagaatgtga tggcgatggg cgacagcctt 438241 aatgacattg cgatgatcaa agaagcgggt cttggcgtcg caatgggcaa tgcgcaagac 438301 atcgtaaaag aaacggctga ttatatcacg gatacaaata ttgaggatgg tgtcgctaaa 438361 gcgattcgcc attgggtact ataaaaaaag agagtcctaa gatggactct cttttttagt 438421 ttggcaggtt ttattctggg accatggtag gttttctgac aaaagtattt cacaaactga 438481 tatgattcac ttataatgaa ataaagttca aaaattcgga atagtcgttc cgaatttcgg 438541 gacaataaat gacataaagc atatcgtttg ctttggcagg agggattctg tgtttcagat 438601 tgatttaaac tgtgatttag gagaaagctt cggagcctac aagataggcc ttgaccaaga 438661 tattttagag tatgtgacat cagcgaatat cgcatgcgga tttcatgcag gagatcctag 438721 tgttatgcga aaaaccgtcg cgcttgcagc agaaagaggc gtgaaaatgg gtgcgcatcc 438781 gggcttgccg gatttactcg gttttgggcg ccgcaatatg gcgatttctc ctgaggaagc 438841 gtatgatctt gtcgtttatc aaattggcgc gctctctggc tttctaaaag cagagggact 438901 tcacatgcag cacgtcaagc cgcatggcgc tttatacaat atggcggcag tcgatcaaaa 438961 actgtcggat gctatcgcga aagctgtcta taaggttgat cccggcctga ttcttttcgg 439021 tcttgctgag agcgagcttg taaaagcggg agaacggatc ggacttcaga ccgcaaatga 439081 agtgttcgcc gacagaacat accaatcgga cggcacgctg acaccgcgct cccagccgga 439141 cgcactcatt gaaagtgatg atgccgccgt cacccaggtc atcaaaatgg tgaaagaagg 439201 ggcggtcaaa tctcagcaag gacatgatgt gtcattaaaa gcagatacag tctgcattca 439261 tggagatgga gcccatgcgc tgacatttgc gcaaaaaatc agaaaacagc tcaaagcggc 439321 tggaattgaa gtgacagcta tttcagaaca gaggtcaaca taaaggagga acaatagatg 439381 gagcagcaga aaaagacagc aggaaaaaaa gcgggcagct ggtcattgct gatgggcgcc 439441 gcctttttaa tggcgacatc agcaatcgga ccgggtttcc tcacccaaac cgcaacattc 439501 acaaacacac tcgcagcaag cttcggtttt gtcatcttaa tctctattat tttagatatt 439561 ttcgcccaaa ccaatgtgtg gcgcatcatc gcagtttctg gaaaacgagg tcaggaaatt 439621 gcgaatatgg tgcttcccgg actggggtat ttcatcgcca ttctcgtcgt gcttggcgga 439681 ctagctttta atattgggaa tatcggaggg gccgggctgg gacttcaggt gctgttcggc 439741 attacacctg aaacaggcgc tttaatcagt gccgttatcg ccattttgat ttttgtcatc 439801 aaggaagcag gaaaagcgat ggaccgtttt acgcaaatcg cggggttcgt gatgattatt 439861 ttaacggtct acgttgcggc gacgacagct cctccggtcg gacaggcagt cgcaaataca 439921 ttcgtcccgg aacacatcag catatttgcc attgtcaccc tagtgggcgg aaccgtcggc 439981 ggttatatca catttgccgg aggacaccgt ttgcttgatg ccggaattaa aggaaaggaa 440041 tccattccgc aggtgacaaa gagctcggtt gtcggcattt taattacatc tgtcatgcgt 440101 atcgctcttt ttcttgcggt tctaggcgtt gtatcgaaag gcctgcacat cgatgaaagc 440161 aacccggcgg cttctgtctt caagctggct gctggaaatg tcggttataa aattttcgga 440221 ttgatcatgt ggtctgcggc gattacgtct gttattggag cagcctatac atctgtttca 440281 ttttttaaaa ccttttctcc aaaaattgaa aagaattcac gcggtattat tatcggattt 440341 attgtggttt ctacgttagc ttttgtcaca atcggccagc ctgcgaagat cctcgtcctt 440401 gtcggttcac tgaacggctt aattctgccg attgcgctcg gaacgctgct tgttgccgcc 440461 tacaagaaaa acattgtcgg tgattataag catccgcttt ggctgacaag cacaggcgcg 440521 cttgtagtga ttgtaatggc agttatggga atctacacgt tatgtacaca acttcctcaa 440581 ttgtggagct gatataagtg gagcaattaa acaaaatggc gccaaaggat gtacgcgccc 440641 tgatacgaga ggggaaaata aacgggccga ccgcaggcat gtccggcggc tacgcccaag 440701 cgaatcttgt ggttttgaaa aaggaccttg cgtttgattt tctgctgttt tgccagcgaa 440761 atcaaaagcc ctgccccgtg ctggatgtga ctgaagcagg ttcgcctgtg ccgtctctgg 440821 ctgcgccgga tgctgatatc agaacggact ttccgaaata ccgtatttac aggcacggta 440881 tcctaacgga agaagtatct gatattacgc catactggga ggacgatttt gtcggctttc 440941 tgatcggatg cagtttctcc tttgaacagg cactgatcaa taatgggata gctgtccggc 441001 atattgatga ggggacaaac gtctcaatgt ataaaacgaa tatcgattgt gttccggcgg 441061 gggcgtttca cggacagatg gttgtcagca tgaggccggt tcctgaacgg ctggctgtac 441121 gtgctgcaca agtgacctcg cgttttccgg ctgtgcacgg agggccgatc catattggca 441181 atccgggagc aatcgggatt cgcgatctcg ggaaaccgga tttcggagat gccgtttcca 441241 ttcgtgacgg cgaggttcct gttttttggg catgcggagt gaccccgcaa gccgtggcta 441301 tgaatgtaaa gcctgaaatg gtcatcacac atgcgccggg gcatatgctc atcacagata 441361 ttcgagacga gtcgcttgcg gtgctgtagc ctctcgtcat cctgatgaac gagaattaaa 441421 agaggtgaga aagatgactg tacgatatca aatcgaacag ctcggtgatt ctgcaatgat 441481 gatccgattc ggagaagaaa tcaatgaaca ggtcaacggc attgtccatg cagcggccgc 441541 ttatatagaa gaacagccat ttccgggatt cattgaatgt atcccggctt ttacaagtct 441601 aaccgtattt tatgatatgt atgaagtgta caagcatttg cctcaaggca taagctcacc 441661 ttttgagagt gtcaagcgcg atgtcgaaga gcggctggca gaaatagccg aagactatga 441721 ggtcaaccgc cgtattgtag aaattcccgt ttgctatggc ggtgaattcg gtccggattt 441781 agaagaggtg gcgaagatca atcaactgtc accggaggaa gtaatcgaca ttcatacaaa 441841 cggtgaatat gtggtgtata tgcttggctt cgcgcccggt tttccttttc taggcgggat 441901 gtcaaaacgc attgcagctc cgagaaaatc atcgccaaga ccgtcgattc ccgcaggttc 441961 ggtcggtatt gcgggattgc agacaggcgt ttatccgatt tcaacgccgg gcggctggca 442021 gctgatcggc aaaacgccgc tggctctttt ccggccgcag gaaaacccgc cgacattgct 442081 gcgggcggga gatattgtga aattcgttcg catctcagaa aaagactatc acgcctataa 442141 ggaggagtcc aattgagcat gaaagtatta aagcccggac tgctcacaac ggttcaggat 442201 ataggcagaa cgggttacca aaaatacggc gttctggcca gcggcgctat ggacacggtt 442261 tcactgcgca ttgccaatct gttgatagga aacggcgaaa atgaagcagg tctcgaaata 442321 acgatgatgg ggcccggtcc gtcgtttcat ttttcaaaac agacactgat tgctgtgaca 442381 ggggcggact tcacgctgcg tattaatgac gaggaagcgc ctttatggaa gcctgtgctc 442441 atcaaggaaa acagcacggt cagctttggc ccctgcaaac tcggcagccg tgcttatttg 442501 gcggcagctg gcggcattga ggtgcctgcc gtcatggaaa gtaaaagcac atacgtcaga 442561 ggaagcattg gcggacttca tggcagagcg cttcaaaaag aagatgaact gaacattgga 442621 gagatgtcag ctctttcgca aaccatcctt tctcgcttaa gttcgcagct tggaaaacag 442681 ggatttgcag caccgaagtg gtcagtcagc cgcggcagat ttctgccatt gaagaagaat 442741 cccgtcattc gggtgctgga aggaaagcaa tttgcctttt tcacagaaga atcaaaaacg 442801 cgtttttatg aagaagcatt tcgtgtcacg ccgcagtccg accgtatggg ctacaggctc 442861 aaaggagaac cgctcgaact gaaggccccg cttgagatgg tgtcggaagc ggtttcattc 442921 ggaacagttc aggtgccgcc tgacggcaac ccgattatcc tgcttgcaga ccggcagacg 442981 actggcggct atccgaggat cgcgcacatc atatccgctg atcttccgat tgtttcccaa 443041 atcatgccgg gcgagcacgt tcagtttgag cctgtgtccc tccaggaggc agaagcgctt 443101 gcggtagaac gggaacagca tataaaagaa ctgaaaacga gaatgaagat ggaatggctg 443161 acatagcaaa ggggatgaat gatgcagaat aaaaataaaa ccgtagtcaa atctatggcg 443221 ctgcttaatt tgtttttgca taaaccaagc ctaaccttaa gtgaactggt gtcgctgacg 443281 ggaatgccga agacctctgt tcaccggatg gtcagctcct tggaggaaat ggggttcctc 443341 agtcgggatg cgtccggcgc ttattcgctg ggattggtgt ttttggaatt cggacagctt 443401 gtcgctgaca ggctggatat cagaaaaata gcgaaaccgg tgatggaaga gctgtgccgg 443461 gaagtggatg aggccgtgca gttgatcatg agggacggca atgaagcgat atacgttgag 443521 aaaatagaag ggacacagac tgtgcggctg tatacggcga tcggcaggcg ttccccccta 443581 tacgcgggag cgtgcgccag aagcattctg tcctttcttc cccgtgaaga aatcgaagca 443641 tacatcaaac aaaccgagct catttcgatt ggctccggaa cgattaccga tcccgaaaaa 443701 ctgcttcagg agattgatgc ctctgtgcaa aatggctata ctgtcagcta ttcagagctc 443761 gaaaactata cggcggcgat cggcgccccg atctttaacc atgagcgcca ggtggcagcc 443821 ggcattagca ttgcaggctt tgaagcgaga tttacagaag acaggctgcc ctatttaaca 443881 gaaaaggtga aggacgccgc tttacagatt tcaagaaaaa taggatatac ataagtagcc 443941 aatcttttct ctgctgcgta cattaacgta tcgacgttca agagtggagg aaagaacatg 444001 gtgcttcgat atacagctct gggcgattcc ttgacgacag ggagaggctc cgggctgttt 444061 tcacccggct tcgtccagcg ttttggggac atgatggaag ctgacttgaa aacaagaacg 444121 gcaataaaca tatttgccag atcaggtctg aatacagaag agattttggg actcctgtca 444181 tatccctatg tgcaaaaatg tattcgagat gctgatatga taacgatcac agggtgcgga 444241 aacgatctca tcgattcggt cttagcctac caaacctcta aggatgaaac gattttcagc 444301 cgtgtatccg cccattgcca tgagaatttt gaaaagatga ttgccaaagt cgccgagatt 444361 aaaggagaaa atccttcccc gtacgccatt cgtgtgttca acttatacaa tccgtttccc 444421 gaaattgata tcgccggcaa atggatcact tcgtttaatt cacatttaga aacacttgca 444481 tcagcacccc atgtcaaaat cgcggatgcc tatagcatct tcaaaggcaa agaacaggaa 444541 tatctgtcct ttgacggtgt ccatccgaac agcaaaggct atcaagcgat ggctgaagcc 444601 gttcacaagc taggctataa agaattatca gtttcataga aaacgcgcct catgacaggc 444661 gcgtttttta tgtgtgatcg aaatattaaa agaaacttaa aattctctgt cttctgttct 444721 acagacaaac aaagtgcgct agaataatgg agggcgtagg caaatatagc cataacgttc 444781 aatatttcgt atataaggaa ggatggtcct tttgtttcgg atttttaaaa tgtcttttgc 444841 ggttatcatt attatactgg cgcttattgc ttttaactat acggaacaca cctctgtaat 444901 ccaatcggtc atgctcgtct ttcttggtgc ggtcatgttt atgcaggggc ttgaagagcg 444961 caaaaaagaa aatgacggct caggcgcttt taatatttat accgccgttt ttgtatggtc 445021 tgtctccctt atcggtttta cacttcatat tatataaatc tattacacat cctgaaaatg 445081 ctcgaccgtc gggaacgggg tatagaaccg atgaagcaag gctttccact cttgatactc 445141 tgaagaaccg cgaaagcctt ccgtatggtc ctcaagtgtt tcccactcca caagaagcag 445201 atatttatgc gtttcctcca tgcattttga taacgagtga gtgatatagc ccttcatgcc 445261 ggaaataatc ggcgcagctt gccggaatgc atcctcaaac tcttgttcaa ggccttcttt 445321 aatgtgaagc attgctgcct ctctgaccat gctatccctt ctttctgtct tttcaaatag 445381 tctacagcaa acgataggag atttctgcaa aatcggtgaa cttttccttc attttcaaaa 445441 aaatcttgca cgcaccaatt caattaagag aaaataacaa gtggaaggca ggggaaagtc 445501 atgttaaaaa agtgtattct actagtattt ctatgcgtcg gattgattgg gttaatcgga 445561 tgctccaaaa cagattcacc agaggatcgc atggaagcat tcgtgaaaca gtggaacgat 445621 cagcaattcg atgacatgta tcaaagcctg actaaagatg tcaaaaaaga aatctccaaa 445681 aaagatttcg tcaacaggta taaagccatc tatgagcagg ccggcgtaaa aaatttgaaa 445741 gtcactgcgg gagaagtaga taaggacgat caagacaaca agacgatgaa acatatcccg 445801 tataaagtca gcatgaacac aaatgccggc aaagtcagct tcaagaatac tgctgtgctg 445861 aaattagaaa aaacagatga cgaggagtca tggaatatag attgggaccc atcgtttatt 445921 ttcaagcagc tggctgacga caaaaccgtg caaattatga gcattgaacc gaaacgaggc 445981 caaatttacg ataaaaatgg aaaaggctta gccgtcaata cagatgttcc ggaaattgga 446041 attgttcccg gagagcttgg cgataaaaaa gagaaagtca taaaagaact cgccaaaaaa 446101 cttgatttga ctgaagacga catcaagaaa aagctggatc aaggctgggt aaaagacgat 446161 tcgtttgtgc cgctcaaaaa ggtcaagcct gaccaggaga aattagtttc tgaagcgacg 446221 tcattacaag gcgtaacaag aacgaatgtc agctcccgct actatccgta tggcgaaaag 446281 acagcccatt tgacaggcta tgtccgcgcc attacagcgg aagaactgaa gaaaaagaaa 446341 gaaggaacgt acagcgatac gtctaacatc ggtatcgccg gacttgaaaa tgtgtatgaa 446401 gacaagctaa gaggcacaac tggctggaaa atctacgtgc cgcaaaccgg ggaagtcatc 446461 gctgaaaaga aagcaaagga cggcgaggat cttcacctca caattgatat caaaacgcaa 446521 atgaagctgt atgatgaact gaaggatgac agcggggcgg cagtcgcgct gcagccgaag 446581 acaggcgaaa cactcgccct tgtcagcgcg ccttcctacg atccaaacgg atttattttc 446641 ggctggagcg ataaggaatg gaaaaagcta aacaaagata aaaacaatcc gttttcagcg 446701 aaattcaata agacatacgc gccaggttct accattaaac cgattgcggc tgctattgga 446761 atcaaaaacg gcacccttaa agccgatgag aagaaaacaa tcaaaggcaa ggagtggcaa 446821 aaagattcaa gctggggcgg ctattcagtg acacgtgtgt ctgagagact tcaacaagtc 446881 gatttggaaa acgcccttat tacgtcagac aatatttatt ttgcccagaa tgcgcttgat 446941 atgggagcgg acacctttac aaaaggcttg aagacattcg gtttttcaga ggacgttccg 447001 tacgaattcc cgatccagaa atcgtctatt gcaaatgaca agcttgattc agacattttg 447061 cttgcggata caggctacgg acaagggcaa atgcaaatgt ctccgcttca cttggcaact 447121 gcttacacgc catttgttga caatggagac cttgtcaaac cgacgctgat caaaaaagat 447181 tcacaaacag ctgatgtttg gcacaagcaa gtggtcacga aggaaggagc ggcagacatt 447241 acaaaaggtc tgaaaggcgt tgtggaagat gagcgcggat cagcgtatca gcctgtcgtg 447301 aaaggaatca cagtggctgg aaaaacagga acagccgagc tgaaaacatc aaaagatgat 447361 aaagacggca cggaaaatgg ctggtttgtc ggctacgatt acgaaaacaa agacctgctt 447421 gtcgccatga tgatccaaaa tgtgcaggac cgcggcggca gccactatgt cgttgagaaa 447481 gcgaaaaagc aatttcaatc gaattaaaat gtctttttaa aaggagcgaa aggaaaaagg 447541 ggatctgagg ccgaatgaac tagtaagggg gcaaaacccg gtttatacaa agaaaagagg 447601 gattttgcat gcagcgtatt caattggcgg aggatcttca attttcaaga gtcatacacg 447661 ggctttggcg gctgaatgaa tggaactatt cagatgctga acttctaagc ctcattgaat 447721 ggtgtatcga tcacggcatc acgacctttg atcatgcgga tatttatgga ggctatacgt 447781 gcgaaaagct gtttggaaac gcccttgccc tttcgcctgg attaagagaa aacatagagt 447841 tggtcacaaa atgcggtatc gttcttgaat cgcctgaacg gcccgctcac agatcgcatc 447901 attataacac aagcaaatcg catattttgg catccgttga gcaatcgctt atgaacctta 447961 ggacggatta tatcgatatg cttttgattc acagaccgga cccgctcatg gatccggagg 448021 gggtagcaga ggcgtttcag gccttgaaat gctctggcaa ggtcaggtac tttggcgttt 448081 caaattttaa agatcaccag tatcggatgc tggaatcata tttgcctgag aagctcgtaa 448141 ccaaccagat tgagctttcc gcatacgaat tagaaaatat gctcgacggc actttgaacc 448201 tgtgccagga aaaacggatt ccgccgatgg cttggtcgcc tctggcaggc ggcaaagtat 448261 tcactgaaaa cacggataaa gaccgacgtg tccgtacggc gcttgaatcc gtccaagggg 448321 aaatcggcgc cgcttcattg gacgaggtga tgtacgcatg gctgtatacg catccggccg 448381 gcatcatgcc gattgtcgga agcggaaagc gcgagcggat ttccgccgcg ataaatgcgt 448441 tgtcatacaa gcttgaccag gatcaatggt tccgcatttt tacagccgta cagggttacg 448501 atattccata aaaagcatca gtttaccagc tgatgctttt tcaatattgt cacaccgctt 448561 agtgccaaat taccatttat aagtgattga ttctttcttg aaagcgtttt atattaaaag 448621 gaaacctctc tatatcctct actgcatctc cttgcgactt catccgcaca tcaagattgg 448681 ctaggaggtc ttttttatgt atatgactgc cagagaacaa aagctgttaa agcacttatt 448741 attacaaaac agatatataa ccgtaactga gcttgctgag ctgatgcaag tcagcacgag 448801 aaccattcac agggaactca aatcaattaa accgctgatg gaaaccgtgg ggcttacgtt 448861 agataaacag cccggtaaag ggttgaaagc agtgggaagt cccgagggta aacaaaagct 448921 gcttactgat ttatcatatg aacagcatga atacagcgcc gacgaacgga aactgctcat 448981 tctttgttcg ttattagagt ctcaggagcc cgtcaaactg tacacgcttg ctcatgatct 449041 ccaggtgacg aatgccacgg tcagctatga cttagatgag ctcgagaagt ggatttctcc 449101 ctttggactg acactgatcc gcaaaagagg ttttggcatc cagctcatag ggccggagaa 449161 tgcgaaacgg aaaattgtcg gcaacttgat tgtgaaccgt ctcgacatcc aaatgttttt 449221 ggaagcggtt gaattaaaca tcaaaggaaa aaccgattct tcagagaaaa tgttcggggt 449281 tgtcagcaaa ggtgagctgt taaaaatgga gcgcatctta tttcagctca aagaaaaaat 449341 cgctttttca ttgtccgaca gctcctatat agcgctcgtc gtccatctga cgtatgcgat 449401 cgaacgaatt aagcttgggg aaactatcac catggagcaa aatgagcttg aggaactgat 449461 gaatgcgaag gaatacagct ccgctcttga aatcgcgggc gagcttgaac gtgccttcgg 449521 cgtgacgatt ccagaggcgg aggtcggcta tattacaatc catcttcgaa gcgccaatcg 449581 aaaatacaaa acagaataca aagcgcagga aattgagctg gaaacagccc tgcaaacaaa 449641 gcggctcatt gcttttattt cagacaaaat cagaatggat ctgacgaaaa actactcttt 449701 atatgaaggc ttgattgccc atttggagcc ggccgtcagc cgcataaaag aaaatattga 449761 gatatacaat ccgatgaagg aacagatcaa gcgcgattat tttctgcttt atatggcgat 449821 cgaagaaggt gtcgaaaagt attttccggg catgtccttt tctgatgatg aaatcgcttt 449881 tatcgttctt cactttggct cggctcttga aatcaaaaaa gaagaagcaa aagtgaaagc 449941 gcttgtcgtc tgctcaagcg ggatcggctc ctcgaaaatg cttgcctcca gactgaaaaa 450001 agagctgccg gaaattgaat cgtttgatat gtcatctctg atcgagctaa aggggaagga 450061 tgttcaagcc tatgatatga ttgtgtccac tgtaccgatt ccttatgaaa acattgatta 450121 catcatggtc agcccactat taaatgagga agacgcaaac caggtcaagc agtatatcaa 450181 gcggaagatt ccccttattc ttaacaaaaa aagaagctcg aaggaagagg cgcagcaagc 450241 tgatgtacct gacatgctgg aggcggcgga aagcataggg cggtatatgg aagttatcca 450301 agatgttctg cgccatttta cgctagctca actcaaaaca aacccggacc atagcatgct 450361 tctgctagag ctttttcaac agctgaagaa ggatggcctg atccgtgatc cggaaaaagc 450421 cgcggtttgc ctggctgagc gggagaaaca agggggattg ggaatccccg gaacaaacat 450481 ggcgctttat catctcaaaa atgatgaaat cgtcctgcct tttttcaaaa tgtttgatct 450541 cagcaccccc tatgaagtgg atggcatgga cggaaatacc ctcaggatga cacgcattct 450601 cgtcatgatg gcgcctggct cattatctgc tgaaggctcg gagattttaa gcgcgatcag 450661 ctcggcaatt atcgagagcg gagaaagcat ggcggggttt caggaagaag gaggacaaga 450721 attgtatcag cggttaaacc gcatattttt cacatggatg aaagaaaaaa acatactgta 450781 aacctgcatg gcacacgtca aaaatttggc gtgtgttttt ctgtggatgg ggaacaaaat 450841 aagaaaatgt gggactattt tatcattcag tattggaata attccaaaat gaaatagttt 450901 tacaagttat cttttttggg ttaaaatggg tgaggtaagg aagaaaatct aacaaattat 450961 tgaagattca agagaatata ggagatgacg atatggaaac attacagcat ctgattctgc 451021 atgacatgcc gaatagcgaa gaaatagagg ctgtaaaaag cggagaccat acactgacat 451081 ataaaggtta ccgtaaacgg attaatcagc tggcgaatgc catgcttcaa aaaggaattc 451141 aaaagggcga ccgtgttgca ttgctttgca aaaacggcca tcccgcctca actgttatgt 451201 tcgccgcact tgaaataggt gctgttgtcg tacctgtcag ctggcagctg aaaccatatg 451261 aaatgacagg cattttaaaa gcaagtgaac caaaagcgat gttttacgga gcggagttta 451321 aagagatact ggatgaagtt cttcctgaat tgtcctcact gtgtgtaaca atggaaacag 451381 gaacagctta cgaaacatct gctgaatttg aagcgctgtt tgcaggtcct gatcatttgc 451441 cagagacgga aatggtttca cctgatgata cagcacttct gatgtttaca tctggaacaa 451501 cgggaaaccc gaaaagatgc atgattacac atggcggcat atacagatac gttaaaaaat 451561 ccaacagctc aatagcacgt atgaagggcc ttcgttttct cgcgtgccat ccgatttatc 451621 atacgagtgc gctcatttgc atcatgcttg gaacgtttgc agaaacaaca tttgtgttta 451681 caaaggatca agatcctgtt cacatgctga aggtcattga agaagagaag attcagaccg 451741 tgatggctct tcctgtgttc tacacgtatt tgcttgaggc gtgggaaaag caccaaactg 451801 acttatcttc gcttgttatt ttaatgacag gcggaacaaa agtgccgagc agcctaataa 451861 gccgctatct tgatattggc attccgcttg cgcatggcta tggaagtact gaggcttggg 451921 gcatcagcac atggacgcct gatatgggaa tggataaagc ggcatctgca ggaaaacctg 451981 tggcaggtgt taaagtcaaa gtggaagatc ctctgaccgg agaagaactt cctcaaggag 452041 aaatcggcga aatcgttgtt catactccat tcttatttaa aggctatgaa gacaatcctg 452101 aagcaacagc gaaagtgctg caaaatggat ggtttagaac cggagattca ggatatgtag 452161 atgaagatgg ctttattttc atcacgggac gctacaagga tgtcattatt tacggaggcg 452221 ataacgtcta tcctgatcag gttgaagaag ttatccagca gatcccggga atccttgaaa 452281 cggctgtggt cggtattcct gacccgcttt acggtgaaaa accgaaagct tttatcgtga 452341 aaaatggcgg ccagcgcatc acggaagagg atgtcatcgc attttgtaaa gaacgcctgt 452401 ccgcttacaa aatacctgaa gttgaatttg ttaacgaact gccgaaaaac aaccttggca 452461 aggtgaaaaa agacgtcctg cgcaatcagg ctgtacattc ataaaagaag aagcccgtcc 452521 actttatgtg gcgggcttct ttgcagttgc acagacggaa agctcaggct taatgttctt 452581 aaattgtata tcaatgtctt cgaagccggc tgctttaaag tcagcaatca tctgtcttcc 452641 aaatgatttg gttttctcag gactggcatc cgcttcccgc ggctgcatcg taatggctgc 452701 tttgccgcct ggctttaatg cccgataaat ctgttttatg ccttttgttt ggtcattcca 452761 aatggtgtag ttgttaacgg aaatcacttt atcataaaac gaggcgggga gaggaaatgt 452821 ctcgatgctt ccttgtatca ggcgtacgcc ctttggtttc actctgcggg cggccagctt 452881 cagcatggcc tctgatacat caatcccatg aagatgaaca tccttctcgc gtttcagcat 452941 ctgctgcatg cagtatcccg ggccaaaccc gacttctaaa atgctgtccc cgcgcgtgat 453001 acccagctga ttgattgtcc actgattcag tgtttgattt tcagcagcca tgatgtaccc 453061 ggcaatcatg ccgatgacgc cctttggcct gctgaatctt ctagaaagca tgttaatcat 453121 tcagcaacca accccctttt tgagttaatt tcctctcagc gttccatgtg aaacattttt 453181 ctgataaagc aatgcgaagg tgccaagcca tgtttatcca aagagtgtgt gaggtacaca 453241 acaaatagac atgaaaacaa aggaggagaa tcatcatggc aaattatcca aaagaactgc 453301 cggcacaaac tcaaagtcgc cagccgggaa ttgaaagcga aatgaatcca agtccggtgt 453361 atgagtacga ggattataaa ggagcagaca aattaaaagg aaaagtagct cttattacag 453421 gcggcgacag cgggatcgga cgcgcggttt ccgtcgctta cgcaaaggaa ggcgcagaca 453481 tcgccattgt gtataaggat gagcatgaag acgctgagga gacgaagaaa cgtgttgaac 453541 aagaaggcgt aaaatgcctg ctgattgctg gtgacgtagg tgaagaggaa ttctgcaatg 453601 aagcggttga aaaaacggtc aaggaactag gcggccttga catccttgtc aacaatgcag 453661 gtgaacagca cccgaaggaa agcatcaaag atattacgag cgaacagctt caccgcacat 453721 tcaaaacaaa tttttattct caattttatt tgactaaaaa agcaattgat tacctgaaac 453781 cgggcagcgc catcatcaat acgacatcca tcaacccgta cgtagggaac ccgacactga 453841 ttgattatac agcgacaaaa ggggcgatca atgcctttac aagaacaatg gcgcaggcgc 453901 ttgtcaaaga cggcatccgt gtaaatgcag tcgcgccggg tccaatttgg acgccactaa 453961 tcccagctac gttccctgaa gaaacagttg ctcaatttgg gcaagatacg ccgatgggcc 454021 gtcctggaca gcctgttgag cacgtcggct gttatgtgct tctggcatca gatgagtcct 454081 cttacatgac aggtcagacc ctgcatgtca acggcggaaa ctttgtgacg acataagagg 454141 gagtgagaca tatgggcatc acgaaagaag aagtgaacag ctactatcaa aaagcaggga 454201 ttgtattaac ggacgaggaa gtagaccaaa tccagctgat ggattacggc ttaggaaaag 454261 aaagaaaagt cgggctccag ctcttcgtct acgtcaatac agaccgttat tgttcaaagg 454321 aattggtgct gtttccggga cagacttgcc cggaacaccg ccatccaccg gtcgacggcc 454381 aggaaggcaa gcaggagacc ttccgctgcc gctacggaaa agtgtatctt tacgtagaag 454441 gagaaaaaac gccgcttcca aaagttctcc ctcctcagga agacagagaa cactatacgg 454501 tctggcacga aattgagcta gaaccgggcg ggcaatacac gattccacca aacacaaagc 454561 attggttcca ggccggggaa gaaggtgccg tcgtgacgga aatgtcatcg acgagcacgg 454621 ataaacatga tatctttacc gatccaagaa tataaggatg ggcttaacag cccatccttt 454681 ttgtattgaa aaaaacagaa tcatcgctat aatgggtaaa aaaggaaaga gggcgaggca 454741 atgttcactt gcaaggtaaa tgagcacatc accatccgat tattggagcc gaaggatgcg 454801 gagcggctgg ccgaactcat tatccaaaat cagcagcggc ttggcaagtg gctgtttttt 454861 gcggaaaatc caagcagcgc tgacacgtac cgagaaacaa tcattccaga ttggcggcgc 454921 cagtatgccg acctgaacgg cattgaggcg ggtctccttt atgacggcag cctatgcggc 454981 atgatcagcc tgcataacct tgatcaagtg aatcgtaagg cggaaatcgg atattggatt 455041 gccaaagaat ttgaagggaa aggcattatt acagctgcct gccgaaaact cattacgtat 455101 gcttttgaag agcttgagct gaatcgtgtg gcgatctgtg cggctgtcgg aaacgaaaaa 455161 agcagagcgg ttccggagcg gatcgggttt ctagaggaag gaaaggcacg ggatggctta 455221 tacgtaaacg gcatgcatca cgacctcgtc tactacagtc tgttaaagcg tgaatgggaa 455281 ggcgaaaaat aaagagcaca ctttcttgtt taaatcttcc ccggatgtgg aaaagtaaca 455341 gcggagacgt taaaaaggag tgattcgaga tgaatcagca agacattaaa caaaaagtgc 455401 ttgatgttct agatcaccat aaagtaggtt cgctcgcaac agttcaaaag ggcaaaccgc 455461 attcccgcta catgactttt ttccatgacg ggctgacgat ttacacaccg acaagcaagg 455521 aaactcataa agcggaagaa attgagaaca accccaatgt ccacatttta ttaggctatg 455581 attgtgaagg ttttggcgac gcatatgtcg aagttgccgg aaaagcaaag atcaacaatt 455641 cggcagaact caaggacaaa atatggagtt ccaaattaga gcgctggttt gacggcaagg 455701 atgatccgaa tctggtgatt cttgaaattg aaccggagga tatcagatta atgaatgccg 455761 gggagaaaac accggtctca ctcgaactat aaaaaatttg tgttttcagg ggcgatatgt 455821 tattatgaat agctagtaag aaaaataagc aaataaaaaa gaaagtaaac ttcttttttc 455881 tgttttgaga gagaagctta ccgcttccca agcagcataa ccagctgccc ttattctttt 455941 ccttcataac aaatcgcccc taacgatgag atggaaaaaa gacttttttg ttttacaatt 456001 cacaccggcg cggcttcgga gccgcagtga cgattgagag gtagggcttt cgttgtcttg 456061 tgttcaagaa atttccatgg tgtttacttt ccagaatgat tcttcggaac aatgctttat 456121 gaatctaacc cgcctgactt ggcggatgat ataatcttta tttgcgtata gaaaagaata 456181 agacaaaccg cccggcgtac gccggacggt ttttttattg caaaaaacac atcgtactga 456241 aacctccttg tcttctttcc agtcttatct ctaggatgaa attggaggaa gaataacgtg 456301 catgtcatta caacacaagt actttttatt ttttgttttt tattgctgat tcactcgata 456361 gaaaccttag cctatgcgac aaggctttcc ggagctcgcg ttggatttat tgcgtccgcg 456421 ctttctctgt ttaatgtcat ggtcatcgta tccagaatgt cgaatatggt gcagcagccc 456481 tttactgggc atttaattga tgatgctgga aaaaacgcac tggcgattgt aggggagcag 456541 ttccgctttt taattttcgg atcgacagtc ggcaccattt tgggcattat cctgctcccg 456601 tcttttgtcg ctcttttttc acgggcgatt attcacttgg cgggcggcgg cggctccgtt 456661 tttcaagtat tccgaaaggg attctcgaaa caaggattca aaaatgccct ttcctatttg 456721 cgtctgccgt ccatttcata tgtaaaagga tttcatatgc gcttgattcc gaagcgtttg 456781 tttgtcatca acatgctgat cacatcgatt tatacgattg gtgtgctttc ggctttatac 456841 gcaggccttt tggcgccgga gcgcagcacg acagccgtca tggcttcggg tttgatcaac 456901 ggaattgcaa cgatgctgct ggctattttt gttgatccta aggtatccgt tcttgctgat 456961 gatgtggcaa aaggaaaacg aagctatatc tatttaaaat ggacctctgt cacaatggtc 457021 acatcaaggg tggcgggcac actcctcgcc cagctcatgt ttattcccgg ggcctactat 457081 atcgcgtggc tgacaaagtg gttttaataa gaaaggctgg atcataaaga tccagccttt 457141 ttgcgcttcc ttatttatag ttccttaatc cgcggtcgta caaaaaattt ccgaatggga 457201 cgaaagcggc gatgaagccg gcagctgacc atttcagcgg ccatttgaca gagaaggttg 457261 cataagccaa gacaagcaaa tacaaaatga acaacccgcc gtgaaccgaa ccgacaattg 457321 tcaccgcaag cggaaggcct gcccaatatt taagcggcat agcgatgaac aacaggatta 457381 agagtgacat tccttcaata aaacccatcg tgcgaagtct tccgatcggc gtgtgcagca 457441 taaatcgccc tccttgtgga cacgttttca ttttatacta taaacaatcc gggggggcat 457501 atgacagctt tcaaaaaatg ttcggaaaac attcattttt acatgccttt tctagggaac 457561 tgtacttgtc atttacaaaa atacccgaga taatgtgtac aaaatcaaaa aagaaggatg 457621 ttgaaatgaa acttgaccag attgatctga atatcattga ggagctgaag aaggacagcc 457681 gtttgtcgat gagggaatta ggcagaaaaa ttaagctgtc gcctccatct gtaacagaac 457741 gggtaagaca gcttgaatcg tttggcatca tcaagcaata cacgctggag gtcgaccaga 457801 aaaaactggg gcttcccgtt tcctgcattg tggaagcaac cgttaaaaac gcggattatg 457861 agcggttcaa aagctatatt caaacattgc cgaatattga attttgctac cggattgcgg 457921 gtgcagcctg ctatatgctg aaaatcaatg ccgaaagcct cgaagcggta gaagatttca 457981 ttaacaaaac atcgccctac gcgcaaaccg tcactcacgt cattttctca gaaattgaca 458041 cgaaaaacgg gcgcggttag agagtgccgc gcgaagtctg ttataataac aggatgagcg 458101 tgaaagaaag agaagtgatc aagcatgtca aaaacagttg tattagctga aaaaccttca 458161 gtcggccggg atttagcccg ggtactgaag tgccataaaa aaggaaacgg ttatctcgaa 458221 ggcgatcaat atattgtgac ttgggcttta ggccatttgg tgacgcttgc tgatccggaa 458281 ggctacggaa aagaatttca atcatggcgc ctagaggatc tgccgattat cccagaaccc 458341 ttgaagcttg tggtgataaa aaaaaccgga aagcagttca atgcagtcaa atcccagctt 458401 acccgtaaag acgtcaatca gattgtcatc gcgactgacg caggccggga aggtgagctt 458461 gttgcgcgct ggatcattga gaaagcgaat gtccgaaaac caatcaagcg gctgtggatt 458521 tcatctgtga cggataaagc gatcaaggaa ggttttcaaa agctgcgcag cggcaaagaa 458581 tatgaaaacc tgtaccattc tgccgtcgcc agagcggaag cggattggat tgtggggatc 458641 aacgccaccc gtgcacttac cacaaaattc aatgcccagc tctcatgcgg gcgtgtgcag 458701 actccgacgc ttgccatgat tgcaaagcgc gaggcagaca ttcaggcgtt tacgcccgtt 458761 ccgtattacg gcatacgtgc tgcagtcgac ggcatgacgc tgacgtggca ggataagaaa 458821 tcaaagcaga cgagaacgtt caatcaagat gtaacaagcc gtttgctaaa aaatctccaa 458881 ggaaagcaag cggtcgtagc tgagctgaaa aaaacagcga aaaaaagctt tgcgcctgcg 458941 ctttatgatt taacggagct ccagcgtgac gcccacaagc gcttcggttt ttctgccaaa 459001 gaaacgcttt ctgtcctgca gaagctatat gagcagcata agctcgtcac atatccgcgg 459061 acggactcta gatttttatc cagtgacatc gtcccgacgt taaaagaccg tctggaaggc 459121 atggaagtaa aaccgtatgc ccaatatgtc agccaaatta aaaaacgcgg cattaaatct 459181 cataaaggat atgtcaatga cgcgaaggtg tcagaccacc acgcgattat cccgaccgaa 459241 gagccgctcg ttctcagcag tctgagtgat aaagaacgaa agctgtatga cctgattgcg 459301 aaacgtttcc tggctgtatt aatgcctgca ttcgaatatg aggaaacaaa ggtcatcgca 459361 gaaatcggcg gagaaacctt tacggcgaaa ggcaaaaccg tgcagtcgca agggtggaaa 459421 gccgtttatg atatggcgga agaggatgat gagcaggagg atgacagaga tcagacactt 459481 cctgcgcttc aaaaaggcga cacacttgcc gtccgcacgt taacggaaac aagcggccaa 459541 acgaagccgc ctgcccgctt taatgaaggg accttgctgt cagcgatgga aaacccaagc 459601 gcgtttatgc agggagaaga aaaaggcctc gtcaaaacgc ttggagaaac aggcggcctc 459661 ggcacggtgg caacgcgtgc cgacattatt gaaaaactgt tcaacagctt tttaatcgag 459721 aaaaaaggcc aagatatttt tatcacatct aaaggaaaac agctcctgca gcttgttccg 459781 gaggatctga aatcaccggc cttaacagca gaatgggagc aaaagctgtc tgcgatcgcg 459841 gccggcaaat tgaaatcggc tgtttttatt aaagatatga aggcttacgc tcaccaaacg 459901 gtaaaagaaa tcaaaaacag cagccaaacc ttccgacatg acaacattac gggaacggca 459961 tgtccggaat gcggcaaaat gatgctgaaa gtaaacggca aacgcgggac gatgctcgtg 460021 tgccaagatc gtgaatgcgg aagcagaaaa acgattgccc gaaaaacaaa cgcacgctgc 460081 ccaaattgcc ataaaagaat ggagcttcgc ggccaaggcg agggccaaac ctttgcgtgt 460141 gtgtgcggtc accgtgaaaa gctctctgta tttgaaaaac gaaaaaacaa agacaaagcg 460201 cgtgctacca aacgggacgt atcctcttat atgaaaaaac aaaataaaga tgagccgatt 460261 aacaacgcgc tggcagaaca gctgaaaaaa ctcggtttgg ataaataata aaaaaacctg 460321 tgcctatcgc acaggttttt tattggactt aggtcctgtt ttcttaatgt tcaaaaaggg 460381 aaaaaaaagc tagcaatctg catttttttt cttttatagt aaatgtactt tgtaacatgg 460441 cagtcatatt ttcgtctata actatttgtg agcgtctgat ttgcttcagg cgacaaaggg 460501 ggatttgcct gtgaggcatg tactaattgc tgtcatctta ttcttcttat ctatcggact 460561 ttccgcaggg tgtgctgaag ctggaaacaa gacccaaaat cagtcggcga cagaagtgaa 460621 tgccagcccg ctccagccgg cggaatattt catctatcac aatttaatga atgacaaagg 460681 gctgatcaaa accgattttt cagaccagcc ttcttacttg tcggaatctc tcggactgtg 460741 gatggagttt ctgctcagca aaaatgacgc accacatttc caggatcaat atcagcatct 460801 gactgattca tttctgatga gcaatcactt ggtgacgtgg aagattcaaa atggccaagc 460861 gagcgggacg aatgcgctga tagatgatat gagaattatg ctgtctcttg accaagccgc 460921 cgcaaaatgg ggccgcagcg actacgcgca aacggctagg gatatcggca cgtctttgaa 460981 gacatacaat atgaacaacg ggttttttac agacttttac gactcacagg ccgcttcaaa 461041 ggatgtgacg ctttcatacg tcatgcctga tgccttagct gtcttaaaga agaatggaat 461101 catagacgaa gaaacagaac agcggaatgc caatgttctc tattcagctc ctttaaaaaa 461161 tggctttctg ccgaagacat acagctcgga gacgaaggaa tacacatatg atagtgaaat 461221 caacctgatt gatcagcttt acgctgcttg gcatttgccg gaaggggatg aaaaagcatc 461281 tgttttagcg gactggatca agcaggaatt tcagaaaaac ggaaagctgt acgggcggta 461341 ttcggcatat acgaaggagc ctgccgtcca atatgagtct ccatccgtat atgccttagc 461401 cgtattgttt ttgacaaaac agcatgaaaa cagttctgtc atcaaagcca tatatgatag 461461 aatgaatgac tttgaaattc atgatccggt gaaatcgtat tatggaggct atatgagcgg 461521 cactcagacg cattcatttg acaatctgct gccgctgtta gccgaaagga agctttttaa 461581 tgaaaatatc attcagtgaa tcacaaaaat tatttgctta tttttcaggg ctcatcgcgg 461641 ccctgtcttt gtttatttat tatgtgtcag cccagcaatc agaaggtgct ctgatccttt 461701 gcatcacatt tggcgtcatc gccgcaggca tctggttcgg cccgatttac gcgctggcag 461761 tgaccttaat cgtactcttt gttctcggca ccttaatgat gtttttccag actggacaga 461821 catcgctctt tccggctgag gaagggctgc gaatgcttgt cgtgtgggga atcgcgcttt 461881 tgctgttttc ttttatttct ggaagaatcc acgatattac agcagagctt cggcgctcaa 461941 tgacacggct tcaatccgaa attaaaagct atgttgctgt tgacagagtg actggttttg 462001 ataacaagca aaggatgaag ctggaacttt cagaagaaat caagcgggcg gagcgctacg 462061 gcaattcttt tgtgtttttg ctgctccata tgcattattt caaagagttt aagtctttgt 462121 acggtgaaaa agaaacggac cgcctcttcc aatatgtcgg tcagcaaatc aggacaagcg 462181 ttcgggaaac ggataagaaa ttccgtccct ctgacgagcg tatcgggatc gtgctgacgc 462241 acacgcctgc tgaacatatg ccggccgttc tgactaagct gaagaaacaa ttggatacat 462301 atcagctgga aaatggaaag tatgtgtcgc ttacgttcca cgtttgctat ttgccctacc 462361 gcaacgatat ccaaacagct gatcaatttt tagaagaact ggaaaacgag atgatgatga 462421 atgaactata aaggaatcac attgctatgc gtcatgatgc ttctattttc agctattgcg 462481 tcttttcccg tttctgcgca agcgaaagat caggatgccg gcattctcat catctactca 462541 accttggacg gcaaagagtc gtcacaagtc aaaatgctcg atttgcttgc gggccacttt 462601 acatcccatg tgacagtcaa aaaagattca gacgttgaag cgtcggattt caaagggaaa 462661 gaccatgtga tttattacgg ccaaacgaaa agaaagctca gccaaaaatt gctgtctctt 462721 atcagcggcg tgaaaaaacc ggttgtcgcc attggctata acgcaggcca aatcagccaa 462781 ttttctgggc tttcattagc ccgcaaagaa aatgtgtttc aggttcacag caggtcagaa 462841 aaggccgatg tgtctctgga aagcgggctt aacgtgctga gtgtatcagg cctgaaagga 462901 acggcgcttt acaccttcaa agcggatgaa ggcacaacgc attcttttat atggaaaaca 462961 aaaaaaggga atgtgtacat tggattaaca aatttgttaa atgacaattt gatcgtggcg 463021 aaacagctca gagaagcttt cggagagaag gcggggacga cgttattgta tttgcgtctc 463081 gaggatatca gcccgatgtc tgatgaaaaa ctgctgcttc aagccggtac atacctgcat 463141 aagcggcata ttccttttat cctggcggtc attccggttt acttgaatcc ggaaacaggc 463201 gacaaagtgt atttgtctaa tcaaccgaag atggtcaagg tgctgaagaa gctgcaaagc 463261 atgggcggca gtatcatagt tcacggctat actcacgctt atcgctacag tgaaacagga 463321 gagggatttg aattttggga tgcaaaggcg gatcagccga ttacatccgg aaatgccgaa 463381 gaccccccgt ccattttgga gaaagaacag gacttcccga acgaacaagc ctatcacagc 463441 tatcttgaac catttcggga aaaggaagaa acgtatacaa aacaaaaact gacgcgtgcc 463501 attgaggatt tgacatcatc gggtctttac ccgctggcgt ttgaagcgcc gcattacacg 463561 atgtccgaat atggctatca aatcgcctcg cagtatttta caagcatttt cggccaggtc 463621 cagctcagca gcacaacatg gaaaacatcc ggtgcacctc cgtttgtgac tgctccttcg 463681 atgctgcacg gaatgacgct ttatccggaa acgatcggct ttgtcgacac atcgaagcaa 463741 aacccgctcg gtgagatgga ggagcatatc tcccagatga ttgattttga aggcggagta 463801 gccggaggat tttatcaccc gtaccttggg atgaaatatc tgcctgagct ggttgatcag 463861 atggaacgca ttccagacag tgaatggctt gatttaaaga aaacgaaaca aaccgtcaaa 463921 acagacaaag tggaaattca tacaagcggt gacggaacga ttcaggtgaa aaacggcgta 463981 agccccattt acgagttttt cgatcatcac cggcaaaccc ctctggaaaa ggcgttatgg 464041 attctctccg ctgttgtgct cttatttgtc atcatgtttg tcagttatac gttttacttg 464101 agagccacat tgaaaaaacg aatttttaag gagagaagaa gccttgggta atacgctgtt 464161 ctttatctcg ctaagtttaa tatgggttat gcttctctac cacatgttcc tcatgcaggg 464221 cgggtttcgc cactatatga ccttcgaacg gaatatcccg aagtggagag aaaatatgaa 464281 ggaactgccg aaggtcagcg tcctcatccc ggcgcataac gaagaggttg tgattcggca 464341 gacgctgaag gccatggtca acctttatta tccgaaggac cggctggaga ttatcgtcgt 464401 taatgataat tcatcagacc ggacgggtga tatcgtcaat gaattttccg agaaatacga 464461 tttcatcaaa atggtgatta cgaagccgcc aaatgcagga aaaggaaaat cctctgcact 464521 taactcgggt tttgccgaat cgaacggcga tgtgatctgt gtgtatgacg ccgacaacac 464581 gcctgagaaa atggccgtgt attacctcgt gctcggcctg atgaatgacg aaaaggcagg 464641 cgccgtggta gggaaattcc gcgtcatcaa tgcggcaaag acgctgctga cgaggtttat 464701 taatatcgaa acgatctgtt ttcagtggat ggcccaggga ggcagatgga agtggttcaa 464761 aatcgccacg atcccaggca ccaacttcgc gatccgcaga agcattatcg aaaagctcgg 464821 aggctgggat gacaaagcgc tcgctgagga tactgagctg accatccggg tatataatct 464881 cggctatcac atccgctttt tccctgccgc catcacgtgg gagcaggaac cggaaacatg 464941 gaaggtatgg tggcgccagc gcacccgatg ggcgcgcggc aatcaatatg tcgtgctcaa 465001 atttttggcg cagtttttta agctgaaacg aaaacggatt atctttgatt tgttttattt 465061 tttctttacg tacttcctgt ttttctttgg cgtgatcatg tcaaatgcga tttttgtagt 465121 gaatttgttt tatgatttgc atttgtctgt tggatttttg gcaatgattc tctggatttt 465181 ggcgtttttc ttatttatga cagaggtcat gattacgttg agcattgaaa aaacagaaat 465241 gaacaagcaa aactttttta tcgtatttct catgtacttc acatactcgc aggcatggat 465301 tgtgcttgtt atctactctt tattcgtaga aatcaagcac cgtttattca agcaagaggt 465361 caaatggtac aagacagaac gatacaatca acataaaagc gggtgacctt tttgaaacaa 465421 ataatgattt ttctcacaag cttcatgctg ctggcgatga ctggacaaac ggctcttgcc 465481 aaagacgtac aggtcagcgg ttcgctcctt gggaaaagca gccaagaaca agccaaacag 465541 caggtgctga caagcgagct gattacactg tatggatcaa aagacagcgc agagctgacg 465601 tatcagatcc cggcaggcgc ctcttcgggc aatcagcaat tggtaatcga atacgaggca 465661 tcaaatcttt taatttctcc atcatcgtta acggttgtca ttgatgatga accggtcaag 465721 acgttaaagc ttgatggtga ttccaaacgg aaaacagtga agctgaatct gaataaaagc 465781 cagtctgcgc aaggctatca caacgtatcg ctgaaattct acggcgtaat gaaagagggc 465841 gtgtgcgtca gacaggatac atcaggcaac tggatcaaaa tttatccgga cagccggctg 465901 acacttgctg acagcagtga agcgaaggga acgtcgctgg accattatcc gtatcctttc 465961 gcccaatctg gaaatacagc ggaagaaaca gctatcgtca ttccggataa cccaagttca 466021 gcagaaatag aagctgctgt taaaacagaa ggctatttga aaacggtgga cagcagtgtc 466081 agtattgcgt atgtcacgga atctgaactg aaaaaaatcg ataagccgac gattgttatc 466141 ggcgtggaca agcattggaa cggcaaagtg aaaaaactgt tgaaacaagc cgggctacag 466201 gcaaaaggag aaaaccttct gcttgcggag cgggtgctga aagcagaggg caaacagcag 466261 ccggttctgt ttgcgcaagc ggcgtccgag gacgcgctca caaaaaaaat cagcgtgatg 466321 acagatcaga catatacagg ccagctcagc ggcgatacac tttcaatcag caagcttcag 466381 cagactgaaa aaaaagaaag cgataagctg acccttgaga attttggagc gggtgatatc 466441 acaattggag ccgacaaaac atcttcagca cattattttt atccggcttc ggctgtttta 466501 gatgaaaacc aatcggcgaa gctgtcgctt aaactgaaaa agtctgaaac gattcaagcc 466561 tcaacggctg aaaacgagtc agcctctcag gctgcagaac tgaaagtgat gatcaacggc 466621 cagccgcact cggtccggct tgatgaatta ggaaaagaag ataaaaacgg attctatcat 466681 gtcacagtga aagtggaccc taagctgctg caaaaaaacc gctacattga tattcagttc 466741 gtcacgaccg gtttaaagga aaacaaccct tgtaacacca ctgatgaaga aaagtgggtt 466801 tttatcgata aaaacagtac attatcatac gccatcaaag gcatgtcccc gtcagcggat 466861 tttcaagagt ggccgctgcc ttacgccgga aaccaggatc aaacaacgtt aatcgtgctt 466921 cctgacaccg taagccaatc gaagctagag gagctttctc tcgtaacaga atcctttggc 466981 aacgaagcac agcattcata tacggtaaag aaatcatctg acgttacagc aaatgatgcg 467041 aaaggacgaa acctcatttt cataggaggg atcaatcaat tttctcttct gaaggagaaa 467101 tcatcagatc tgcttgtgcc gcaggaaaag aacggctcgt ttgatgtatc tagtttcgag 467161 atgctgaatg agacgacaaa acaagtggta tttacccaag catcggtttg ggattcacgc 467221 tatacaatgg ctgtctttgc accgtcaaaa ggagatggca cggctgtcac aaaagagatc 467281 atcagttatc tgaacagcaa cgatgagtcg gcaaccgtcc ttaatgaaac aaacagccag 467341 caggtgttta caaaccacca gcagctcaaa tcggaaacaa acagttccga tgcagaacaa 467401 ccaacacagg atcatagcca gaaatggatg tatattggtg tgctggcact cattatggtg 467461 gttgcggcag tgttcatttg gattgccgta agacgcaaaa aaagaaagac agatacagaa 467521 taaaacagag gcgattttag cctctgtttt tttatttttg gtaagtaaat tccatttgtg 467581 gaacctgtca ttttattttt ttctctcagc caataagcct ctttacaacg tgcgggaacg 467641 ggagtatgat ctcttttaga aaacaaatcg cttaatctga aatcagagcg ggggacccaa 467701 tagaacggct ttttgccgtt ggggtgaatc ctttttaggt agggctaact ctcatatgcc 467761 cgaatccgtc agctaacctc gtaagcgttc gtgagaggag atgaatgaaa cctgtgttcg 467821 atgttatggc acaggggcat ccgtttgcct ctgtgttttt tgttgttcat ttttgaatgc 467881 aaatcgcata cagagacatc atagcagaaa ggactatcat caacatgtga gagcaagaca 467941 ctgatggatg ttttattgtt ttaattgaaa aatgagaaat taaaagggga agacatcgat 468001 gtatcattca atcaaacgtt ttttgattgg gaaaccacta aaatcccaag cagctggaga 468061 gcaaaaactg acgaaattaa aagccttggc tatgctttcc tcagatgcgc tgtcatctgt 468121 cgcatatggg acagaacaaa ttctaatcat tttggcaaca atcagtgcag ccgcattttg 468181 gtactccatt ccgattgcgg ttggcgttct catcttgctg ctcgcactga ttctttcata 468241 caggcaaatt atttacgctt atccgcaggg cggcggggcg tatatcgttt ctaaagaaaa 468301 tctcggtgaa aaaccgggat tgattgcggg cggttcattg cttgttgatt atattttaac 468361 agtagcggta agtatttccg caggcacgga tgccatcacg tcagcctttc ctgcattgca 468421 tgattatcat gtgccgatcg ctatttttct cgtgttagtg attatgattt tgaacctgcg 468481 cgggctttcg gaatcagcat ccatacttgc ctacccggtt tatctgtttg tggtggcgct 468541 tttggttctc attgcagtcg ggttgtttaa acttatgaca ggacaaatag accagccagc 468601 ccatcataca tcgctcggca cacctgtagc cggcattacg ctatttttgc tgcttaaggc 468661 tttttcctcc ggatgctcag cgttgaccgg ggttgaggcc atttctaatg cgattcctgc 468721 attcaaaaac ccgcctgcgc gaaacgcggc aagaacgctt gcgatgatgg ggattttgct 468781 ggcgattctg ttttccggca tcacggttct cgcgtacggg tatggtacgg cgccgaaacc 468841 tgatgaaaca gtggtttcac aaattgcgtc cgaaaccttt gggcggaatg tgttctacta 468901 tgtcatccaa ggtgtcacat cgcttatttt ggttcttgcg gcaaatacgg gattctcagc 468961 cttcccgcag cttgccttca acctggcgag agaccagtat atgccgcgaa tgtttacagt 469021 caggggcgac cgcttaggct tctcaaatgg gattatcttt ttaggctttg cctccattgt 469081 tctcattatc ttattcgggg gacagacgga gcacttaatc ccgttatatg ctgtgggcgt 469141 atttattcca tttacgcttt cacaaaccgg catgtgcatg aaatggatca agcaaaaacc 469201 aaaaggctgg atcggaaaaa tgctgatcaa ctcctgcggc gctctgatat catttatggt 469261 tctatccatt ctgtttgtga cgaagtttaa tgtcgtatgg cctgtgttaa tctttatgcc 469321 tatcgtcgtt ttgctgtttt ttgcgattaa aaatcactat actgcggttg gtgaacagct 469381 tcgcatcgta gacaaagagc cggaagaaat caaaggcacc gttgtgattg tgcctgtggc 469441 cggtgtcacc accgtcgtgc aaaaatcgat tcactatgcg aaatcactgt ccgatcaggt 469501 gatcgccgtt cacgtgtcat ttgacagaga acaggaaaag aaattcgaaa aacgttggga 469561 agagcttaat aacggagtgc gtctcgtgac gcttcactcc tcttacagaa gccttgtcca 469621 tccgtttgat aagtttttgg aaacagttga ggcaaaagcg aagaaggagc agttttccgt 469681 tatggtgctg tttccgcaat ttataacgaa aaaacgctgg cacaccatcc ttcacaacca 469741 atcggccttc ctcctcagag tccggctgtt ctggaaaaag gacataatgg ttgccacact 469801 gccgtatcat tttaaaaagt aaagctctag gaccaaggga atcaccttgg tcctttttag 469861 cgggaaaagg aggtatgggg gtgtatacac aaggtgcttt tgtgatcgta ttgaacgaaa 469921 gtcagcaaat tctgctggtg aaacgaaaag atgtccctct atgggatttg ccgggcggca 469981 gggttgatcc cggggaatcg gctgaggaag cggcagtgcg ggagatattg gaagaaacgg 470041 gatacaatgc agcgctttct gcgaaaatag gtgtttacca aaggccaaag tttcaagatg 470101 aacagcatct gtttttcgga agcattacag gcggacaagc aatggctgac ggcacagaga 470161 cagcgggatt aaagtgggtt tccccggggc gtttgccgct ttttatggtg ccgaatcgaa 470221 aaaggcagat caatgatttc aagaacggcg ctcaagatgt aaatgtcacc gtcaaggata 470281 gcgggttgct cgcggcgatc gacctgttga aaagaagact gggcaagtga ttcaggtctc 470341 cgggttttaa agcctttctc ctgtggtatt gaaaaaagga aaaaggagga tacgttatgg 470401 cacacaaaac tgcaggacaa gcaatgacag agctgcttga gcaatgggga gttgatcatg 470461 tatacggcat ccccggagac agtataaatg agtttatcga agaattaaga cacgaaagaa 470521 atcaactgaa gttcattcaa acccgccacg aagaggtagc ggcactggca gccgcggctg 470581 aagcaaaact caccggcaag atcggagtct gtctgtcaat cgcagggccg ggagcggtgc 470641 acttattaaa tggtttatat gatgctaaag ccgacggcgc ccctgtgctg gcgattgcag 470701 gacaggtttc ttctggcgaa gtcggacggg actatttcca ggagattaag ctggagcaaa 470761 tgtttgagga cgtggccgtg ttcaacagag aggtacatag cgcggaatca cttccggatc 470821 tcttaaatca ggcgatcagg accgcctaca gcaaaaaagg cgttgcggta ttgagcgtgt 470881 cagatgattt gtttgcggag aaaatcaaac gggagcccgt gtatacttca ccggtgtata 470941 ttgaagggaa cctagaaccg aaaaaagaac agctcgtcac ctgcgcccaa tatattaata 471001 acgctaagaa accgattatc ctggcagggc agggaatgaa aaaggcgaaa cgggagctct 471061 tagaatttgc ggacaaagcc gccgctccga tcgttgttac actcccggca aagggtgttg 471121 ttcccgataa gcacccacat tttctcggca acctcggtca gatcggaaca aagccggctt 471181 acgaggcaat ggaggaatgt gatttattaa tcatgctcgg aacgtcattc ccgtaccgtg 471241 attatttgcc tgatgacacg ccggcgatac agctcgattc agacccggca aaaatcggaa 471301 aacggtatcc ggtgacagcg ggccttgtct gtgattcggc tctcggtttg cgcgaattga 471361 cagagtatat tgaacgcaag gaagacagaa gattcctgaa tgcctgcaca gaacatatgc 471421 agcattggtg gaacgaaatt gaaaaagatg agacagaggc aacaacaccg cttaaacctc 471481 agcaggtcgt ggcccgtctt caggaagcgg cagccgatga tgcggtgctc tctgtagatg 471541 tcggcactgt gacagtctgg atggcgcgtc atttcaaaat gaacgcgaat caggatttca 471601 tcgtttccag ctggcttgcg acaatgggct gcggcctgcc gggagcgatt gcagcgagct 471661 tgtccgaacc ggaacgccag gcgatcgccg tctgcggtga cgggggattt tccatggtca 471721 tgcaggacct tccgaccgcc gttaaatata agctcccgat cacagtcgtt attttaaaca 471781 acgaaaatct cggcatgatt gagtacgagc agcaggtcaa aggcaatatc gactatgtca 471841 caaaacttca aaatgtcgac tatgccgcat ttgcagaaag ctgcggagca aagggcatca 471901 aagtgaccaa agcggaagag cttgcgccgg cttttcatga ggcgctgcac tctgaccaac 471961 cggtcgtagt ggatgtcatg attggaaacg aaccgccgct tcctggcaaa atcacctacg 472021 ggcaggcgaa aggctttagc aagtacatgc tgaaaaactt cttcgaaaac caaaaatttg 472081 aaatgccgtc actgaagaaa agtttgaaac ggttatttta aaaaaacagg ggccctaaga 472141 gcccttgttt tttttttttt ttttggaaac aaatgtattt tcagcatgtt tgaattcata 472201 aaatgatcgg tatatgtatt aggaactgat ttcgccatac tcgaaacaga caaaaggaca 472261 aatgcatctt gtttcaaagg aagatgcatt tgtccttgca tgcttattct tatcaaatct 472321 tacagaactc ttctcataat aggttatttt tcttttttct tcagcccgaa gaagaaagga 472381 aaagcagaac cgaccaagaa ggtgccgaat aaaaacatgc cgccgataaa cacgtggaaa 472441 tttgtgtgtc cggccgtaaa cgccgtgatt agggaaatga tactgagcac gatcatggca 472501 atgccgggcg cgactctcat ttttcccttg gatttatggg cagcaacaga acataaaatg 472561 ccgataacaa taggaacaat ccacaaataa aacagaataa atactgacat catcaaaact 472621 ccgatttttc ttctatcata acaaatttct gtcaaaaagg gtatcaatga gcttttgcgg 472681 aaaaataaaa accggcttta gaagccggtt tttttatcga aacgtatcta caattaaaaa 472741 cacattcaaa gcaacgatca atacagcaat cagccaagac accactgtga tccatttggc 472801 gttgatcaga gatcccatga tccgtttatt gcttgtaaac ataataagcg gaatgagggc 472861 aaaggcgatc ccgaaggaca gcacgacctg gctcagtacg agagcggtcg tcggattaac 472921 acctgacgcg atgatcaaga tcggcggaat gatcgtgata aaacgccgta catacagcgg 472981 aatgcggtag ttgataaatc cttgcataat cacgtcgcct gaaagtgtgc cgacagacga 473041 actggataga ccggcaacga gcagcccgat cccgaacaaa gccgcagaca tagggctgac 473101 aagatgtccg aattgctgaa atgcgacgtc gagatcctca acaaacaggc cgtttttgaa 473161 gaataatgcg gcagccacaa tcagcatact tgcattaata gcccctgcaa tcagcatcgc 473221 tattaaaata tcaataaatt caaacctaaa gatttttttc cgttctgcat cagttttgcc 473281 aaccacccgc cgctgtgtaa gggcagagtg taaataaatg gcgtgcggca taacagttgc 473341 gccaagaata cccgctgcaa gaagcacact gtcggtgcca tgaaacgccg ggacaaaaag 473401 gcccttcatc actgacacgg catcaggctt tgcgaaaaag gtctgcaacg caaaggcgat 473461 cacgaccaca aacagcatac cggcaatacc tgcttcaagt gagcgataac cacggcgctg 473521 aagctccaat atcgcgaaag aaccgatcgc cgcaataata gacgcttcaa gcatcggaat 473581 gccgaacagc aaatacagtc ccagagccgc tccgataaat tccgccagat cagttgcgat 473641 aatgaccaac tcgccctgaa tccataatcc gatcgagaca ggcttcggga attcttcacg 473701 ggcaacctca ggcagatttt tgcctgtcgc aataccgagt ttggcggata gggattgaat 473761 taaaagcgcc atgatattgg aaaataagat cacccataag agcatatatc cgtatttaga 473821 acccgccgaa atattcgttg cgaagttgcc gggatcaata taggcaatgg ctgctataaa 473881 tgcagggccg agaaaaggga gcagccctct gaatcctctg attttcccgt caagcgcatc 473941 ttggacggct ttggaacggg gagattgtgc tgtgatgtcc ttgttcatca tgtctcacct 474001 gaattctgtt tgtttttgcc gtacaacaaa gagtttcctt aaggcaaatt attttatcta 474061 catcatatga ccatcccggt ttcttgtcaa ccgaaaatgt tcaaaataca cttctgaatt 474121 tttccctgtt atgtaacatg atatgtaggg attcgtgata aggtcccata taaaaagaca 474181 tcgtttcatt tcgaaacgat gcctcctgta tctaatgagt ctaggcttcc ttccgcagcc 474241 cgcggaatat aaggcccagc aagaacacga agatggctgc cccgatgatg gccgggaaaa 474301 tagcaaagcc ggcgaggctc ggtccccatg tgccaagaag tccgtgccca atccaagcgc 474361 cgatcagccc ggcaatcata gagccgaaaa ttcctcccgg cagccggttt cctacaatgg 474421 cgctcccaat taatccgata acaattgcaa caactaatga aaccaaaaag ctaagcatca 474481 tgatcacctc tcataaatga tttaccaatc aataaccgct cctgatcatt tcgaaacact 474541 tgaaagcata ttcctttatg atcctgtttt aatctttctc tgcacactgc cgtcagctaa 474601 atgaacaatg acctcagtgc ctttatgcgc cgcgatttcc tttgcccgtt caatcgcttc 474661 tttctttgta tccttgattt cagacacacg tttggcgccc tcggctttga ctgcccagcc 474721 ttttttatgc ttaataacat gctctgcttt attcatgagc tcggggccgc tgccgctgct 474781 tggatcagca tcgcgttctg tctcatcatc atgcgtcagg aaatcatcaa tttcatctgt 474841 agaggcgttt tccgcccatt ccttcgcttt gcttgtcgca attggaatcg cgcgcccttc 474901 ctcatagcct tcatcaatca tcgcattcgc aatgtctatc gccttttttc tcaccggctt 474961 ctcaagattt tttaatgaag caggataatc cttcatcgac caaggcatgt ctatcactcc 475021 ttttcctttt ataaaaatgg tacccgcagg tgaaaaataa aaacgcatcc gaaaaaatga 475081 aggtatacta tatagtagaa aaaacggaag ggaagtgcgg gttgggtgcc aacagaacga 475141 aaagaagact tacatcagca attaaaagag atagagaaat gggaaaaaga tcagcaaaaa 475201 gtctggtttt gggaaaagct cagccgtctc ccgtttcaac tcctggacaa gctgacacca 475261 gaattcatcc agaaaaagat cggcaagctc ttggatgagg tcggcagctt tgttcaaaca 475321 ggcggacagt acctgacatc tgaaaaacag attatcagga tgtttcaaaa gaaactgccg 475381 gaggagatct ttgaatcgct ggaggacatc cggaaagcgc ctcttcctgt catggatgaa 475441 attgcggaag gaatgggcaa aaacagaacc aacgcagcaa ccgttcaagg cgcgacaacc 475501 ggtgtgggcg gcgtgtttac gctggcggca gacattccgg cagtgcttgg cttatcacta 475561 aaaacattac aggatatcgc agtcgcatac ggctatgacc caaaggagaa aaaagaacga 475621 gtcttcattg tgaaatgcct gcagcttacg tcggctgatg ttgtcggcaa aagatcgatt 475681 ttgcaggaat taaaacacta cgatcaagac cgtacatata agaatgtcgc ttctcaaatc 475741 caaggctggc gagaagtcgt tttgggctat cgagacacgt ttggctggaa aaaacttttc 475801 cagatagtgc cggttgccgg aatggttttt ggcgccgctg ccaatcgctc aacattaaac 475861 gacattaccg agacaggcat gatgctgtac aaaaagaggc gcattcttga acgactgaaa 475921 gaaacagaac gagagatgga atagcagaaa gcagacggac accgcgatcc gcctgctttt 475981 tttagtggaa acatacccaa tgtgttttgt ttgtttaaaa gaattgtgag cgggaataca 476041 acaaccaaca ccaattaaag gaggaattca aaatggcaga caataacaaa atgagcagag 476101 aagaagcagg tagaaaaggc ggagaaacaa caagcaagaa ccatgacaaa gaattctatc 476161 aagagattgg tcaaaaaggc ggagaagcca ctagcaaaaa ccatgacaaa gaattctatc 476221 aggaaatcgg cgaaaaaggc ggagaagcca ctagcaagaa ccatgacaaa gagttctatc 476281 aagaaatcgg tgaaaaaggc ggagaagcca ctagcgaaaa tcatgacaaa gaattctatc 476341 aagaaatcgg ccgaaaaggc ggagaggcaa caagcaaaaa tcatgataaa gaattctacc 476401 aagaaattgg ctcaaaaggc ggaaacgccc gcaacaacga ctaatcaaaa gcataaaggc 476461 agacaacctg taaataaaaa agcgatccgg cacatcagct ggatcgcttt tttttggaat 476521 cttctcaatt tatgccgcta ttgagataca ataagtgaaa aaggggtttt cgctaatgtc 476581 caagatgcaa aacttgctcg ccatcgcaaa tgaagtcaaa gaaaagcacg ccaatttttc 476641 aatctcagag gtcaacgacc actgcgtgcg ccttgcggtg tttacgggag aatatgactg 476701 gcaccatcac cctgactcag acgaattgtt tattgttctt gaaggggagc tgctgatcga 476761 ttttaaggac aaagaaaccg cggtgctcaa agcaaatgac agcctgctga tccctaaagg 476821 cacggttcac cgcacacgct cttacgtcag aacggtaaat ctctgtgtgg agcataaaca 476881 agccgaaacc gtcatcatag aggagcagcc atgctaatca aaaagatgat atgtgaagta 476941 gatgctgcaa acgctgaagc atttgcaaaa gcgcagtcac agtgggaagc gttatcgcat 477001 ataagcggct ttatcaaaca ggccggcggc tggcgaaaaa cgatagacga gccgctcacc 477061 gcagaaatca tcagtgtatg ggaaaacaga gaagcctatg atcattttat ggagaacgaa 477121 catgacagca tatacgagga aaacgatcag aaggctgtaa ttctttcgat agaggtgacg 477181 gtgtacgaag aggataaacc gttcgttcac gatctgttac ataaccccga tatccggtac 477241 gaaccaaact ggacggttct gaaggcataa tcaaagccca aaacatcatg ttttgggctt 477301 gtctctttac tcgcgtcccg gaagtgtatt atgaacaaaa ggcggtgctg gttttaactc 477361 cggtttttct ccaaacgttt ttgcttcttt cacatattca aaggcttctc cgtccggcgc 477421 tttttcattc agccagtttt gctcggcgct tacttcgcct tcagagaaat tgataagctg 477481 atgtgagaac tcttgttttt cgagcgcttt cgggaatgta cccggcacaa ccggaccttc 477541 ctgtgcttct aattctttaa tggcggcgag ccattggttc tggtgcatcg tgtcacgcgc 477601 cagcaggaag ctgagcatat ctttgacgcc tttgtcatcc gtcatttcaa acaggcgtgc 477661 gacctgcaga cggccctgag attccgcatt caggttggcg cggaagtctg ccagcaggtt 477721 tccgcttgct acgatataac cgccgctcca aggtacgcct gtactgcttt ccggcatggc 477781 gccaagtcct gatacaatcg catggtgagg gttcatgccg cctaggatgg agccgatgac 477841 cggatcttca gcagcttttt cctgctgatc aagaggggca tcctcaagaa gtctggcaat 477901 catcgttgcg atcatttcaa catgcccgag ctcctcagtt gccgtatcca tcagcaagtc 477961 cttgtatttt tcatttcctc ttgtgttcca gccttgaaat aagtactgca tggcaactga 478021 aatttctccg aattgcccgc ctaaaatttc ttgcattttt ttagcgaata atggatctgg 478081 acgatctggt ttagcaggat gctgcagcat ttttgtgtgc ttaaacatgt acccatctcc 478141 tttttcgttt atctcttttt atatttccga tcgatagaaa gataaacgaa aaacagcgta 478201 tcgagatggg aactatgaat cttttcgcag ctccaacagt tcccggatca gctcccggcc 478261 aaagatgggc tcatactgcc ggtaaacagg gtcaagacgc ttcatccatt cttgtttctc 478321 tttatctgac agctcataaa tatgtatagc agaattcttt ttgatttctt ccagctgctc 478381 cttgttcatt tgttcggcat acgtttcatt ccactccgtt gtctccttca tcgcttcagt 478441 caaaatgcgt cttgtttctg gtgtttgcgc cttccagaag tgttcatcag tcatgacagc 478501 gtagccgaga taaccgtggc tgcttattgt caaatagtcc tgaacattat aaaatttttt 478561 agaatagatg tttgaaattg tattttcttc gccatcgact acattgtttt ctaacagctg 478621 aaaggtagaa ttgaaggatt cctgatgagg tgttgcgcca agcagcttga actgatcctc 478681 aatcacatcg ctttgcataa tgcgcagatc ctgccctttt aagtcatccg gtgttttgac 478741 cggcccttga tttgttgtga tttgcttaaa gccgttcgtc caataggcca atcctttcaa 478801 ttggtttttc tttagagaat caaacagctg tgtgccgatg cttccgttca gccctttttt 478861 gacggcgttg taatctgtaa atgcatacgg cagatccagc actccccatt caggcgagag 478921 catgccgagc ttcgatgtgg agggggcgat aaattgaaca tcgccgtttt gcaatgcttc 478981 aatttcttca atgtccgagt acaggcttcc attcggaaat acttctattt ttatttttcc 479041 gcctgatttt tcgttcacca gatcagcgaa tttattggcg gccagccctt ttggcgtatt 479101 ttcagcaacc acgtggctga atttaaacac gatttgatcc tgcaggcctt cctggtcgtc 479161 atcataaaca atctttttat tgccggtatg atcatggaat ccgataaata aagcggttgc 479221 aattccagcg atcatcagtg cgagacatgc aagcaaactc ttcatgaaaa gccctcccct 479281 atgttaagga taatgggggc tatgacattc gtaaagacct gaaaggagaa gctgatgaac 479341 aaaaagaagc tctcaatccg ttggaaaatc acgatcttat cctatatact cgtcattttc 479401 tcctttttga tcggcggcat tgtgctcatc ggcaacattc agcatacaga ggagcgggag 479461 ctgaaaaagc ggctgatgaa tacggcccgg acggtgtcag agatgacaga agtgaaagaa 479521 gccttggcgc gaaaaaaaca aacagaagcg gttcgccatg cggttgaaga aatcaggatg 479581 attaatgaag cagactatat tgtcgtcatg gatatgaatc acatccgata tacgcatcct 479641 gtcagcacaa gcattggcaa gaaatcagaa ggtgcagacg aggaggcagc ttttgcggag 479701 cacatttatt tctctgaagc aaagggcgag atcggcacgg cggttcgcgc tttttatccg 479761 gtaaaggatc aagacctgaa ccaaataggc gtggtgcttg tcggaaaaac gctgccgggg 479821 atcgctgaca tcctgcttca tttaaagcgt gatatcgcct tcatcgttgt gctgacactc 479881 ggctttggcc ttgctggttc ctttttgctg gcccgccata tcaaaaaaca aatgtttcag 479941 cttgaacccc atgagattgt ccgaatgtat gaagaacgga cagcgacgtt tcactcgatg 480001 aatgaagggg tgatcgctat tgacaatcgt ctcgtcatta cgatcttcaa tgaaaaagcg 480061 aaacagatct ttgaagtgca gggggatcta atcggcaagg tgatttggga ggttctcaag 480121 gattcgcgcc tgcccgaaat cgtggagcgg aacaaagcgg tttataatga agaaattcgt 480181 gtcagcggta aggtgatcat gagcagcaga attccgatcg tcatgaagaa aaaagtgatc 480241 ggcgccgttg cgatttttca ggacagaacg gaagcggcca agatggcaga ggaattgact 480301 ggtgtcagaa actttgtgga ggcgctccgt gtccaaaacc atgagcatat gaataagctg 480361 cacacgatcg ccggtctcat ccagctgggg aaatctgaaa aagccttgca gcttgcattc 480421 caggcgtcaa ctgagcagga aaatgtgact gaatttctgc accgctcgat tcaaaatgac 480481 gctgcggcag gccttctatt aagtaaaatc agaaggggaa gagagctcgg cattgctgtt 480541 catatagatg aaaacagcag tcttcagcaa tttcccgagc atgttgatca gcatgatatt 480601 gtcgtgcttt tggggaatct gattgaaaat gccttcggct catttgaaac cgttcaatct 480661 gaagacaaac gaattgacat tagtatcgaa caaacagatg atatccttgc tattttaata 480721 gaagataacg gctgcggaat tgaaccgaca catatgcctc gcctttatga caaaggtttt 480781 acggtcaata aaactggcgg cacaggctat ggcctgtatc tagtgaaaca aatcatagac 480841 aaaggatcgg gcacgataga agttgattca catgcggggc aggggacatc tttttctatc 480901 gtttttccaa tgaaggggga ggaagcacag catggctcgt aaagaatgga aggttctgct 480961 cattgaagac gatccgatgg ttcaagaggt caataaggat ttcattacaa ctgttaaagg 481021 cgttactgtc tgtgcaacgg caggaaacgg agaggaaggc atgaagctga ttaaagaaga 481081 acagccagat ctcgtcattc tcgatgtgta catgccgaaa aaagacggca tcaagacctt 481141 gcaggagatc agaaagcaaa agcttgaagt ggatgtcatt gtcgtctccg ctgcaaaaga 481201 caaggaaacg atctcactca tgctgcaaaa cggggcggtt gactatatct taaagccgtt 481261 taagcttgag cgaatgagac aggcactcga aaagtacaag caatataaac aaaaaatcga 481321 agcgaatgat acgctgtccc aggaacagct cgatgcgatc ctgaatattc cgcagcaggc 481381 cgtacaggat ctgccgaaag ggttgaatca cttcacgatg aatgaagtca ctgctttttt 481441 gaaacagcaa accgcatccc tttctgctga agaggttgcc aaggcgctcg gcatcgccag 481501 agtgacagcc agacgatatc ttgattactt agaaaaaacc gggatcatca aattggacgt 481561 tcaatacggc ggagtcggcc ggccggtcaa ccgctacgtg ttaaaaggat aaacctgaga 481621 ccaaaaagac caaaatgtcc gttatgatca taaacttccc cagactgtat gaaaacgcta 481681 tcattctagt aagaaagaca caaaaggcga ataggacagg gggatgaagg atatgaaact 481741 gtttaaaaat ttaacagttc aggtcataac cgcggtcatc atcggggtca ttgtcgggct 481801 ggtctggccg gatgtcggca aagaaatgaa accgcttggt gatacattta tcaacgctgt 481861 taaaatggtg atcgcaccaa tcattttctt cacaatcgtt ctcgggattg caaaaatggg 481921 cgatatgaag aaggttggaa aagtaggggg aaaagcgttt atctatttcg aggttgtcac 481981 caccctcgca ctcattatcg gtttatttgt cgtcaatatt atgaagccgg gtgcgggtct 482041 tgattacagc aagcttgaaa aaggagatgt atcacaatac acgcaaaatg gcggtcaggg 482101 aatcgactgg attgaattta ttacacacat tgttccgtcc aacatggttg atgccttcgc 482161 aaaaggggac attttgcagg tcttattctt ttctattctt ttcggagtgg gtcttgcggc 482221 attaggcgaa aaaggaaaaa gcgtcattga tttcttcgac aaggtttctc acgttttttt 482281 caaaattatc ggctacatta tgcgtgccgc gccaatcggg gcattcgggg cgatggcgta 482341 tacaatcgga cacttcgggc tcgattccat caaaccgctg gcaagcttaa tgatgtctgt 482401 ttatattacg atgttcctgt tcgtatttgt tgctttaaat atcatctgca agctttacgg 482461 attcagcctg tggaattacc ttcgcttcat taaggatgag cttttgatcg tgcttggcac 482521 aagctcttcc gaatcggtgc ttccgcgtat gatggataaa atggagcgct acggctgttc 482581 caaatccgtt gtcgggcttg ttattccgac gggctattcg tttaacctcg acggcacatc 482641 catctattta tcaatggcga ctgtcttttt ggcacaggtg tttggagtag acctcagcat 482701 cggccagcaa attacgatta tcctcgttct gatgctgaca tcgaagggag cggcaggtgt 482761 gacgggaagc ggatttatcg tccttgcctc aacgctgtca gcgctgcagg tcattccgct 482821 ggaggggctt gcactcctgc tcggggtcga ccgtttcatg agtgaaggaa gagccattgt 482881 gaacctgatc ggaaacggaa tcgccacgat cattgttgcc aaaagcgaaa atgaatttga 482941 tgaagcaaaa agcatagagg ctgttgaagg catgaaaaaa atgaaaacag cagtctgaaa 483001 aaagaacggc ccatccatgg gccgtttttt taattgttta agaattatta aggtaaggac 483061 agagacctca gcattttttt gttatataat ttacaaatgg atactatatt gaatgaagga 483121 cgtttgtcct aacaggagtg tataaatggc cgctttagtt aaattttttc agcacccggg 483181 agtaaggcgt ttctccatct ttgtcgtgtt aactggtgtg ttatatctat ttaagagcat 483241 gatcaactta atattgctta ccttcatttt cacatttcta atggatcgtt tggagcttgt 483301 cgtgcggcag tttgtaagcc agttcttccg cgtgagccag cgggttgtca ttacgtttct 483361 ttacatgttg ctggctgtgc tgcttacagt cgggggcttt gtgttttatc cggtcgtcgc 483421 ggcgcagatc cagcagctgg taaagcagat taaacatatt gcgtatcatc ctgacagcat 483481 ccctttcttt gatgagatca ccagtgtctt cggagatatt aacatcagtt catatgtcaa 483541 agagggcttc aatgtagtgt atacgtatct ggccgatatc agcacattcg gcttgcaggt 483601 cgtgatggcg ctcattctta gcatgttttt cttatttgag aaaaaacggc tttctgaatt 483661 catggcgaaa tttaaaacga gcaaacttag ggtcttttat gaggagattg cttttttcgg 483721 aagcaaattt gcaagaacgt tcggcaaggt gctcgaggct caatttatca ttgcgctcgt 483781 caactgtatt ctgacgttta tcgcgctttg gattatgcat tttccgcagc tgtttgggct 483841 ttcgattatg gtgttcttcc ttggattgat ccctgtagca ggcgtcgtca tttccctgat 483901 tccgctcagc attatcgcct acagcactgg cggtggaatg tatgtgctct acattgtcct 483961 tgtcatattc gccattcatg cgatcgaaac ctatttctta aatccgaagc tgatgtcggc 484021 gaaaacagag ctgccaatct ttttcacctt cacagtactc attttctctg aacacttctt 484081 cggcatttgg ggtttaatta tcgggattcc gatctttgtg tttctccttg atattctgga 484141 tgtcaccaac aaggaagata ggtctaaagg accccgagag aatagcgata aaaagtagtt 484201 taaaatcgaa taatgagtgt gcctcgatct gccggcctgc ctgttcaggg catggaatta 484261 agactcggaa tcggagcttg gcattgcctt gcacagtggt gaacacaaca ggtgacaatg 484321 cttgtcatca gtacggaaac tgaaaagaac aaacagtcgg agcaaacgct catcatcggt 484381 ttaaccaaac atttggaagc aacaaatgct ataatacaaa cagtgcctaa tgttgggcac 484441 tgtttatttt ttgtcgaaaa aggaggaagg ctttatggct gagccgattt tacatattga 484501 aggcctcgat aaaaaaattg ggtctaaaca gattttaaaa cagatcagca tggacgtcat 484561 ggagggtgaa atcatcggcc ttctcggtcc gaatggttcc ggaaaaacaa cactcatccg 484621 tatcatcgtc gggctgttga aacaaaacag cggaagcgtg acaatcagcg gattccagca 484681 tgatacagag tttgaaaaag cgatggaagc ggttggagcg attgttgaga accctgagtt 484741 ctatccgtac ctgacaggct gggaaaacct caagcacttt gcgaatatgc acaaaaaaat 484801 agcggatgaa cggcttgatg aagtggtgga acgtgtcggg ctgacgtcag cgattcatga 484861 taaggtgaaa acctattccc ttgggatgcg ccagcgtctg ggaatcgccc aggcaattct 484921 tcaccggccg aagcttctca ttctagatga accgacaaac ggcctcgatc ctgcggggat 484981 gaaggatttt cgggatcata ttaaggaact cgcagaaatg gaaggaacag ctgtcctgtt 485041 cgccactcat ttattgcgcg aggttgaaga cttgtgcgac cgtgtcatca tcattcaaaa 485101 aggtgagatc aaagcggaag tcagcttaca aggaaccgat caaaccacag aaaaagcgat 485161 tatagaagtg cagccgcaag aaaaagcgct caattggctg acaggcaatc aatatcaagc 485221 tgagagccaa gacgggacga ttgtagttga ggtggcaaaa gaaaacatac cggagctgaa 485281 ccgatcactt gtcggacaag atctgaatgt attttccatt acgccttaca cgcagtcact 485341 ggaagacgaa tttataaaag cgacaacagc tcatcaagag gagggagaag agcttgtcta 485401 aattaatttg gaatgaacat atgaaacttt ttaatcggaa ggtcactttg gtttctctta 485461 tcctgatggc tgtctttcaa ttcttcatgg cattgatcat taaacggatt gtcatcagtg 485521 ccggaacaga tgaaaacttc atcggctatt tatcgtatac accgagcctg aacattttgc 485581 tgcaggcttt aacgatcgta attgcagcaa caattgtttc gatggaattt gataaaaaga 485641 cgatcaaatt tttgctcatt cgtccggtta aacgccaaaa ggtcttttgg tcaaaattaa 485701 tcacagtcgt gatggtcagc ttctatttgt atttggcata ctacattctg gcattattat 485761 tcggtctctt gttttttggc acatcggtga ctgcggaatc aaagacattg ctggtcaaca 485821 ccttggcgct gatcgggtca aactggcttg aagctgtaat gatgggatta ttcgggctgc 485881 tttgttcttc gctgttccgc aatagcgcgg tagcagttgt tgtttctttt gtcgttttat 485941 acggagcgag tacacttgtt cagctcatga agttgtttga aaacaagtgg ggcagctttt 486001 tgctttttgc gaacactgac tttacgcaat acagaagcgg agagacagcg ttgttttcag 486061 gcatgacgcc attgttttca attggaattc tcatcataca tgccatattc ttcatcgttg 486121 ttggctggtg gtgcttctgt aaacgggatg ttcgggtcta aaggcaagga atgacatttt 486181 tgtgaaaaag ctcacgtaaa tcaatatcat ttgatatttt ggtttatact aaaggtactg 486241 acggaggtgt ctcgattgag gaactttatt accgctttac cgatcgtatt gctgcttgga 486301 ttctcatttg tgtcattcat gtttcagttt gaacatcttg tttatttcag gctcgcgctt 486361 gggttgtttt ctctcgtggg actgtacatg atatataaaa tgaagacggg catccgctat 486421 tttatcatct atctgtatgc cagctggatt gtgttggccg cagtgaccgc ttttgaagag 486481 ccgattttct caagcttttt ctttggcggc ctggtgatga cgatgggtta cctgacatat 486541 atgctgattt atctcggcat gaaacaagac cgggatgcaa atcctgtgta atcgcgctgt 486601 tcccttgggg aacggcgtgt ttttctatac tgggcaaaag gttaacagtt gcggaaaaat 486661 ggcaggaaat ctataataca tattaaattt atcggaatta aaactggggg gctgccggat 486721 gtcattattt atacaaaacg atcaacagcg gcaatggatg gagaaaatcg gacggattgc 486781 ggatgaattt cagcaaacag ctgctgaaga tgacgaacag ggacgttttc ctgcagagaa 486841 aatacaaaaa ctgcgtgatg ctgggtatac agcattaaca ttgccggcat ctcatggcgg 486901 agggggcatt tctgtttacg atatgctctt gtttcaagaa cggcttgcac ggggagatgc 486961 tccgacggct cttagcatcg gctggcattt gagcgtgatc ggggagcttg gagaaggcaa 487021 cagctgggat gaagacgtat ttgcatttgt tgccaaggaa gtccaaaacg gagccgtcat 487081 taacagggcg gcgactgaag cgaaaaccgg aagcccgaca agaggagggc gtcccggtac 487141 acacgccgtc aaaaaggatg gcaaatgggc agtgaacggg agaaaaacct ttacgacgat 487201 gtcacaagct ctggattatt ttttagtaac cgcatggatt gaggacaaac aaacaacagg 487261 cgtgtttctc attcataaag atgatcccgg cttgtcgatt gaagaaacgt gggatatgat 487321 ggcgatgcgg gcgactggga gccatgacct tgtactgaac gaagtaatgc ttgatgagaa 487381 taagctggtg gaactgcttc aagggcctcg tggagctaag ccgaatggct ggctgcttca 487441 cattcctgcg atttatcttg gtgtggctca agctgctcgt gactatgcag tgcaatttgc 487501 atctgagtat tctccaaaca gcttgaatgg accgatcaag aatgtcccgg ccgtacagca 487561 aagaacaggc gaaatggagc ttgaactgct caatgccaga cactttcttt tccatatcgc 487621 tcaattgtat gacgatccgg tgcggcgtcc acacttgacc agcgagctcg gtgcggcgaa 487681 acatatcgtc acaaacgctg cgctgtctgt tgttgataaa gcgatgagaa ttgtcggggc 487741 caaaagcctg gaacgaacca acccgcttca gcgctattac cgtgatgtgc gcgccggtct 487801 tcacaacccg ccgatggatg acgccgtgat acacaagctg gcagctgaag cgtttgagtc 487861 ataaaaaaaa gagccttacc ggctcttttt atgtattgtt ttgctcttgc agattttttt 487921 gatgcttgcg gtcgatcctg tcataaataa cgttcatcag ctttggattg cccataatcg 487981 cctctttgtt ttcctggatc agctgttggt aagttttcac tttacgcttc ggcatgctcc 488041 ggcgccctcc tgacatgttt gtattcactt tctaactccg tcagcgacaa ttcatacaga 488101 tgacgctttg actttttgta tataccattc tgtattaaca gatgaatgag ctgttttttt 488161 ctgatttctg cagactgagg tgtcattgtg tcaccaacct ccaatcaaac gatattgata 488221 atcattatca attaacttca gtatacaatg tccgcaatag cctgtaaaga tgaaaagagt 488281 cctattcttg gccaatttac aaacattcaa caaatcgaca aaaagtttcc cgggcaataa 488341 tttgctgtcg aaatattccg cttcattgaa cgcaccctgc tatttttcat gttttgaacc 488401 atactatgta atagaatgga ggctggtatt caatggagcg gacagaaaat ctgaaaaagg 488461 gagaaaaagg ggcgctcctc aatatttttg catatgtcat ccttgctgtt gtaaagctag 488521 ttatcgggat tctatatcat tctgaagcgc tgagagcaga cgggttaaat aatggaacag 488581 atattgttgc gtcagtagca gtgctgatag gattgcggat ttctcaaaga ccggctgaca 488641 gcgatcatcc atacggccat tatcgggctg aaacaatttc gtctcttgtt gcgtctttta 488701 ttatgatggc agtcggcatt gaagtgttaa tcggcggagg aaaagcgatt gcgggcggca 488761 caacggaaac gccaaatctt atcgcggcat ggacggcgtt aggcagtgct gtgtttatgt 488821 atggcatcta tttatataac aaaaggctgg cagcgtccat taaaagctct gccctgatgg 488881 cagcggcaaa ggacagcagg tcagacgctt ttgtaagtgc cggcgcgttt atcggtgttt 488941 tttcgtccca gctgaagctg ccgtgggttg atccggtaac ggcttttatc atcggcatca 489001 tcatttgcaa aactgcgtgg gatatcttta aagacgcttc acattcctta acagacggct 489061 tccatttaaa agatcttgag ccttacaaac agaccgtcgg caggatcgaa aatgtgcatc 489121 gcctaaagga tgtgaaagcg aggtatttag gcagtacagt tcatatcgag atggtgatta 489181 cggttgatcc gaagcttaca gtagaagaag gccatggagt ggcggatgaa gtagaagaca 489241 aaataaaaca tgaacacgat gtcactcatg ttcatgttca tgtagagcct gacgacataa 489301 aataaggctg tttaacgaat tagcttatat gttcagataa aaattcagtc acttcttcag 489361 gcgttttggc attggcgctg tgaaggtgag ctgttttttc accgttcttg aaaataagca 489421 ggctgggaat gcccattact tggtattttt cagccaggtc aggaagctcg tccttattca 489481 gctcatacca gtcgttttgg ttgtattctt ccaaaatatc gccgatgaac atattcatgc 489541 gtgtgcagtc tgggcaccaa tcagcataaa actttacaat gatttcttta tcagattgaa 489601 tcagttcatt aaattgttcg tttgttgtga tttttttcat atgtcacatc tccttttcaa 489661 tgccatttta atataaaata aaaaggaatt acatacaaat gcattcaaca tcagcatgcc 489721 caaaaataat tagatcattt tccggtgaaa atgataagat agtaaagatg aattgtagtg 489781 gggggagtat ccattgaaaa caagtctagg attagtgtac ggaggaaagt cggcagaaca 489841 taatgtttcc ctgcagacag ctctggctgt aatcaaagcg ctaaatactg agaagtttga 489901 tatacatccg atttatataa cagaaaaagg cgaatgggtt agaggcgccc gtttaactga 489961 acctgtttca aacgtgaaaa tgcttcaatt tgagcaagga ggcagtgctt tttctccagc 490021 tgccctgaac caggagatgt ttccgcagga agcgtcacag caaaatgaag ccatcgacgt 490081 cgtattcccg ctcctccacg gaccgaacgg agaagacggt acgatccagg gaatgctcga 490141 gctgttgaac attccttatg tcggcaacgg agtgcttgct tcctcagctg gcatggataa 490201 agttgtcatg aaacatttat ttgcgcaggt tggccttgct caggctaaat acgcagcttt 490261 ccttaagaaa gactggactc gttctccgaa agaaagctgt gaggaggttg aacaggaatt 490321 aggctaccct tgcttcgtaa aaccggcgaa cctcggctca agtgtcggaa tcagcaaatg 490381 ccgaaaccgt gaagaactgc aaaaagcgtt tgagcttgct ttccaatatg accgcaaagt 490441 cgtcgttgaa gaaggaatta acggccgcga gatcgaaatc ggcgttcttg gaaatgatga 490501 tcctaaatgc tctgttgtgg gagaaatcgc accgaagaca gatttctacg attacaaagc 490561 gaaatatgag gatggagata ctgatctgat gattccggcg attgtgactg atgaggaata 490621 cgcaacaatc agtgatatgg cgatcaaagc gtttaaagcg atcgacggtt caggactcgt 490681 cagagcggac tttttcctga cagctgacgg cgaagttctg atcaatgaag tcaacacaat 490741 gcctggcttt acacctttca gcatgttccc gttgctctgg aaagaagccg gagtggaata 490801 tgctgacctg attgaacagc ttgtggagct tgcaaaagaa cgccacgctg aaaaacaatt 490861 gattaagcat acattctaat gaagaaggac actgccggta aaagggcagt gttttttccc 490921 gtatatacaa aagaaagaga gggaccttac ttgattaagc gaacagtaaa aaacattgcc 490981 gaaatggtta aaggcacact agcaaatccg caatatgaac aaacagtcat tcatggagtg 491041 gcaaccgata caagaaaact ggaacaacat cagctcttta ttccgctgaa aggggaacgt 491101 tttgacggcc actcttttgt ggagcaggcc tttgaagctg gtgtagcggc tgttctttgg 491161 gatcggtcag taccaaatcc gcccgagaat cacgccgtca ttttagtgga cgataccctt 491221 actgcacttc agcagcttgc aaaagcttat ttgcaggagc ttggcacgcg tgtcatcgga 491281 gtaaccggaa gcaatggcaa aacgacaaca aaagatatga ttcacgccgt attggggacc 491341 cagtaccgtg tccacaaaac tggaggaaac ttcaataatc atatcggttt gccgctgacg 491401 gttttagcga tgcctgaaaa tacggagatc gccgtattgg agatgggaat gagcgccaaa 491461 ggagaaattg acctcttgag ccgactggca aacccggatg cggcagtgat tacgaatatc 491521 ggcgaatcgc atatgcaaga cctcggctct agagagggca tcgcggaggc gaagcttgaa 491581 atcataaacg ggcttaaaga agacggagtg ctgatttata tcggggacga accgcttctt 491641 caaaatgcat acagctgcca gacgaaaacg tacggtacgg gaacgcataa tgattatcag 491701 cttcaggatg tcagccagag tgaggaagga acccatttta caatcaaagg gatagaaaac 491761 acgtttttta ttccaatact cggcaagcac aatgtgatga acgccatggc tgcaattgct 491821 gcaggggctt attttggcat cgcgcctgag gatgcggcaa aaggactgag cggcctaaag 491881 gtaaccggga tgaggcttga actcatcaaa acagacagcg gcctttcgat aatcaatgac 491941 gcttataatg cgagcccgac ttccatgaaa gctgcaattc aattgacaga aagccttgaa 492001 ggctacggca aaaaaatgct cgtgctcggt gatatgcttg aactcggcga tcttgaagaa 492061 acgttccata aagagtgcgg cgctgtgatc agccctgata aaattgaccg cgtctttacg 492121 tacggaaaac tgggagcttt tatcgcggaa ggcgccctga aacactttga gaaagaccgc 492181 gtcagccatt acactgagaa aaaagatctc cttcaagctg tgaaggaaaa cgcatcaaaa 492241 ggcgatttga ttttattcaa agcgtccaga ggtatgaagc ttgaagaaat cgttaaagat 492301 ttaatagaga gcccgctttc ataagaaaat attttgcgaa aaaacgcata ttgcatcata 492361 aaataacctg atatgcaaac actaatgtat gccggccgaa aattatgtat atctggccgg 492421 ctgcggctat gatacaatat atataggtta tttcgcgata cgaacatatt cgtccggact 492481 tttcatcgtg acccgaagtt ctccgctgga ttcttgggag cggatggagc agcagccggc 492541 atattcgaga tgccgatctg cttctcatct tattgaaaaa caaatagtgt aatggtaaga 492601 taaaacttaa agtaattcgg gctttgtata cggatggatc ctgtccttct tgtctaaagg 492661 gcagttttat aagtggtaaa tcacgacatt actgaaacag caattagaag gagtttgaat 492721 aatttgacta taacgtttca agattttaat ttaagttctg atctcatgaa agcaattaat 492781 cgtatgggat ttgaagaagc aacaccgatt caggcacaaa cgataccgct cggactttca 492841 aataaagacg tcattggaca agcgcaaaca ggtacaggta aaacagctgc gtttggtata 492901 ccccttgttg aaaaaattaa ccccgagtct cctaatattc aagcaatcgt aatcgcgcca 492961 acccgtgaat tagccattca agtatctgaa gaattgtata aaatcggaca agataaacgt 493021 gcgaaggttc ttcctattta cggcggacag gatattggac ggcaaatccg ggcgttaaag 493081 aagaatccga atattattgt cggaacacct ggacgtcttc ttgaccacat caaccgccgc 493141 accattcgtt taaacaatgt aaataccgtt gtaatggatg aagcggatga aatgctgaac 493201 atgggattca ttgacgatat tgaatctatc ctttcaaacg tgccaagcga gcatcagaca 493261 cttctgttct ctgccacaat gcctgcgccg atcaaacgca ttgcagagcg cttcatgact 493321 gagccggaac acgtaaaagt aaaagcgaaa gaaatgacgg tttctaacat tcagcagttc 493381 tatttggaag tgcaagaacg taaaaaattc gatacactga ctcgccttct tgatattcag 493441 tctcctgagc ttgcgatcgt attcggacgt acaaaacgcc gtgtcgatga gctggctgaa 493501 gctctgaacc ttcgcggata tgcagctgaa ggtattcacg gtgacttaac gcaggcgaaa 493561 cgtatggttg cgcttcgtaa atttaaagaa ggcgcaatcg aagttctagt cgcaactgat 493621 gttgccgctc gcggacttga tatctcaggt gttacacacg tatacaactt cgacgtgcct 493681 caagatcctg aaagctacgt tcaccgtatc ggaagaacgg gccgtgcagg aaaaacaggt 493741 atggcgatga cgttcattac accgcgtgag aaaagcatgc ttcgcgcaat tgaacaaaca 493801 acaaaacgca aaatggaccg catgaaggag cctacacttg atgaagcgtt agaaggtcag 493861 caacaggtta ctgttgaacg tcttcgcaca acaatcagtg aaaacaacct gaacttctac 493921 atgacagcgg cagctgagct gcttgaagat catgatgcag taacagtggt tgcggcggct 493981 atcaaaatgg ctacaaaaga gccagacgac acaccggttc gcttaacaga cgaagcgccg 494041 atggtcagca aacgctacaa gaaccagcgc tcttctaaac gcagagacgg tcaaggcggc 494101 ggctaccgcg gcggaaaagg gaaaagcaac aaccgttctt cctatgacaa aaagcgttca 494161 aacgatcgcc gttcttcagg tgacagacgc cagaaaaaat cttactaatt tgatcgattc 494221 agagcccaaa acatgatgtt ttgggctttt ttatgttcgt gatttgttat tcagcaaact 494281 ttcagctgac ggaagccatt tttctctgta tgcttaagaa tgaaaccttt ctgtaaaaga 494341 gacgtataaa taacgacgaa aaaaagggag gtaggtattt ttgagagagc agccaaaaaa 494401 ccaaatcagt ccagacggat taaaggtttg gcgacttcaa gagatcatca tatccgctgt 494461 ttgcttgctt attgtcattg cagttgcagt gttaagctat tattttcatt ggccgtactg 494521 gatcagcggc gtgctcggcg ctgtttggct gctgggatcg attgtgacgg tctttatcat 494581 tccgaaggtc cgtcataagg tgtggcgata tgaagtccat gaacatgaaa tagatattca 494641 gtcaggtatt tttgtggtga cacgtgtgat tgttccgatg gtcagagttc agcacgtcga 494701 tacgtcacaa gggccattat taaaaaaata caacctggca acggtgaaaa tttccacagc 494761 cgcgaccgtt cattcgatcc ccgctttaga gatggaggaa gcggatcggc taagagactc 494821 catttcccgt ctggcgaggg tgactgacga tgatgtctga accgaaacgc ctgcacccgg 494881 tggcagtcat tttgaattta tgccatacca ttattcaaac gataaaaaat atcattctgc 494941 cattcttttt tgtgtatatt gtcaattcaa accatactgt ccgtttttac ggagccattg 495001 cgctcggtgt gctgttcatc tggcttgtag cggcaagcat tatcaaatgg agaaggttta 495061 cctatcgaat tgaagatgat gaatttagaa ttgaagaagg cttatttgtt acgaaaaaac 495121 gatacatatc gattgatcgg attcaaacaa tgaatacgag cgcgggcctt gtccagcaaa 495181 tctttaagct tgtgaagctg caaattgaaa cagcaggcgg aggcaaggag gcagaagccg 495241 ttctttctgc tatttctgtt gaagaagcgg aacgcatcaa agaagctgtc tttaagaaaa 495301 aagcgcaaag acgagaaaat gaacttgatg aagaacggct tgaagctgaa gaggagttgg 495361 atccgtccgt tgaggtgcaa gagcactatc gcatgaacgc gaaagaattg ctcatggccg 495421 cttctacctc cggcggaatc ggagtcatta tctccgctgt atttgcactt atttcccagc 495481 ttgatgaagt gctgccgatg gattggttat tcgataaatt ttccttcctt cagcacgcca 495541 gcatcggtat ttatgcggta ctcattttta tcggtttatt tatcgcctgg attttcagca 495601 tcgcgggcat gatgtttaga tacgcgaact ttcaaatcat aaaaaaagag caggaactgg 495661 tgatttcaag gggaattatt gaaaaacatc aagtcacgat tccgctgcga aaaatacaag 495721 ccattaaaat caaagaaaat atcattcgcc agcttttcgg ctttgtaacg gtgtccatcg 495781 tcagcgcagg aggcggcgac cgggaaaaag aagaaggcgc tttgaccatt ctctttccaa 495841 tgattcataa aaaaaagctt ccgcacatgc tccgaacatt tacgccggaa tacacgctgg 495901 aagaaaactg ccgccgcctg ccgcggcgcg cgttgaaacg ctatttgttc cgttctgtca 495961 ttttttcact ctttttgatc atcccgttat gtatcttctt tcagccatgg ggctatctgt 496021 cagtgatcct gctgccgata gaattgctct tcggctatct cgcgtataaa gaggctgcat 496081 ggacgatcaa cggggaccgt cttcagctga cgtctagatt tataggcaga acaaccgcca 496141 ttgtactgaa aaaacgaatg caggtctgca agttcagcca atcctatttc caaaagaaag 496201 gccgcttgta taccatttct acttcggtga aatcatcgag ccatatggaa gagttaacgg 496261 tgagggacgt aggtgaagag gatgcagcct tcattttaaa gtggtactca tatgaaaaag 496321 cggacggtta ataccgccgc tccagcgtgt cggcaaaccc tcgcattcgt tgtcaggact 496381 gcgcttcggt gctcaatgcg aagtggatca acggctaaat tctcaggcgt cctgcctaaa 496441 cgccgtcgtc atcacatcct gtgaaagtcc gctcctatgc tcgtccttcc tagacttcat 496501 gggttttcaa tcacgctgaa aagatgacaa aatcctaaaa tgaaaaccat tttaggattt 496561 tgtcaacaat ctgaagcggc ggttaatacc gccgctcttt tttttgcacg cataaaaacg 496621 aaagaagaaa cccgccgcat agtccaaaca aatgggccat catgttaata ttggagttga 496681 taaacgacat gagaacggca aatgcgagca gtgtgatgat cattttggaa tgctcctgcc 496741 caattaactc attgcgaaaa agaaccataa acaggtatac gccaaatagc ccgaaaatgg 496801 cgcctgaagc cccgacatgc acgtaatcaa gcggctctgt aacataagtg ccgatattgc 496861 cgatgatgcc ggagccggcg tatacaagaa ggaaacgcgc ttttcccagc atgcgttcca 496921 aagccggggc aaataaaaag atggacatgg aattaaacag cagatgtgtg aaaccggcgt 496981 gcagcaaaat cggtgtgata agccgccacc attcaccgtt tgcgacacct agattatagc 497041 ctgtgacggt atccctccat aacacgactg aatgggcagg aagtgaaaaa aacagccaga 497101 gaacagcttg caaagccaat ataaaggtga caacggggta aagcctgata aatgtttgaa 497161 aattttcagt ccgtataaac attccgagcc ccttttcttc attttggtat atctatagta 497221 acacgtttat gagacaaacc atttaaatag tacgtacgca aaggaggtta tcatacatga 497281 tttacggcat tgggctggac attaccgagc ttaaacggat cgcctctatg gctgggcgcc 497341 agaaaaggtt tgccgagcgg attttgacgc gaagcgagct tgaccaatac tatgagcttt 497401 cagagaaaag aaaaaacgaa tttctcgcgg gcagattcgc ggcaaaagaa gcgttctcga 497461 aagcatttgg caccggcatt gggaggcagc tcagctttca ggacattgaa attaggaaag 497521 accaaaatgg caagccctat atcatttgta cgaaactgag ccaggccgcc gttcacgtat 497581 cgatcactca tacaaaagaa tacgctgccg cgcaggttgt gattgaaagg ttgtcaagct 497641 agtctgcata ttagggaaac cccactcata tatttgatag tgcattaagg gagacaagtt 497701 gtttgaggct tttatggtac gcatctgttc tgcctaaacg tgtaccgagc gtaccgttaa 497761 agtcaaacaa gcgatttctt ccttttacat caattgagaa aaaggggttg aaaaaggtga 497821 gaaaaagctt tgttttgctt ttaacgggac tgcttgctgt tcttattctt tctgcctgcg 497881 ggcaaaaaac acagcaagat attgtggccg ggttagatga aaaggcgaaa gaatacacct 497941 cgtacaaagc aaaagcgaaa atgaccatcg agacagggag tgagcctcaa gtatacaatg 498001 tggaaatctg gcacaaaaag ccgtctctgt acagggttta tttagaaaat ccgaaaaagg 498061 accaaaacca agtcatttta cgaaatgaaa acggagtatt cgttctcacg ccgtctttaa 498121 ataagagctt cagatttcaa agcgattggc cgaacaacag cagccaggtt tatctgtttg 498181 aatcgctcgt aaaggatgtt caaaacgatt cggatgcagt tttcacagcg aaagaaaaga 498241 aatacgtatt tgaaacaaaa acaaactatc agcataacaa aatgctgccc acgcaagaaa 498301 tcacatttaa caaaaaagat atgagcccgt catctgtcaa agtgatggat actgaccgga 498361 aagtgatggt caaagtagaa ttcagcagct ttgaatttaa taaacaattt gataaagaat 498421 catttgatga aaagaaaaat atgacccttt ctcaaatgga tgtcgccaca agcgcaaagc 498481 cttccgatac atttgcggtc aaaacgccgc tggaactgcc gcttggcgtc aagctgcttg 498541 aagaaaaaga tatatctact gaagacggga agcgcatcat catgacgtac ggaggagaaa 498601 aatcatttac gttaattcag gaaaaagccc agattgccaa ggcttcctcc tccgttacgc 498661 tgaacggcga accggtaaat ctcggctaca ccatcggcgc cctgtcggat gcatcattat 498721 catggacata tgacggcgta gattaccttc tctcttctaa agatctttct aaagaggaaa 498781 tggtgacagt agcgaaaagc atgcagggac aatcatcgaa ataaccgcca aaggccaaac 498841 atgatttggc ctttttttcg ttagacatcg tttcccttta gcctttaatt ttagtatgat 498901 atgtaaatga tattgaataa aagctaggaa gtgtcgtaat gagcacaaaa cctttttaca 498961 gagatacgtg ggcggaaatt gacttgtccg cgataaagga aaatgtcagc aatatgaaaa 499021 aacatatcgg tgaacatgtc cacttgatgg cagttgtgaa agcaaacgcc tacgggcatg 499081 gtgatgcaga aacagcaaag gctgctcttg acgcaggtgc ttcatgcttg gccgtggcca 499141 ttttggatga agcgatttca ctgcgcaaaa agggattgaa ggcgcctata ttggtgcttg 499201 gcgcggttcc cccggagtat gtggcaatcg ctgctgagta tgacgtgacc ttaacaggtt 499261 attctgttga atggcttcag gaggcagccc gccacacgaa aaaaggttct cttcattttc 499321 atctgaaggt cgatacgggg atgaacagac ttggtgtaaa aacagaggaa gaagttcaga 499381 acgtgatggc aattcttgac cgcaaccctc gtttaaagtg caaaggggta tttacccatt 499441 ttgcgacagc ggatgaaaaa gaaagaggct atttcttaat gcagtttgag cgctttaaag 499501 agctgattgc tccgctgccg ttaaagaatc taatggtcca ctgcgcgaac agcgccgctg 499561 gactccggct gaaaaaaggc ttttttaatg cagtcagatt cggcatcggc atgtatggcc 499621 ttcgcccgtc tgctgacatg tcggacgaga taccgtttca gctgcgtccg gcatttaccc 499681 tgcattcgac actgtcacat gtcaaactga tcagaaaagg cgagagcgtc agctacggag 499741 ccgagtacac agcggaaaaa gacacatgga tcgggacggt gcctgtaggc tatgcggacg 499801 gctggctccg aaaattgaaa gggaccgaca tccttgtgaa gggaaaacgc ctgaaaattg 499861 ccggccgaat ttgcatggac caatttatgg tggagctgga tcaggaatat ccgccgggca 499921 caaaagtcac attaataggc cggcaggggg atgaatatat ttccatggat gagattgcag 499981 gaaggctcga aaccattaac tatgaggtgg cctgtacaat aagttcccgt gttccccgta 500041 tgtttttgga aaatgggagt ataatggaag taagaaatcc tttattgcag gtaaatataa 500101 gcaattaact tacctaaatg gagaattcat aaaacagctt tgcttgaaga gtgaataatg 500161 gtatcattat cactggatgg ataaaagagt cgtatccgta agtttggtgg aggtgtatgt 500221 tttttgtctg aatccagcgc aagaaccgaa atgaaaatca gcttgcccga aaacctagta 500281 gctgaattgg atggtgtagc gatgcgggag aaacgaagca gaaacgaact gatatcacaa 500341 gcagtgagag cgtatgtcag cgaacgaaca actcgtcaca accgtgattt gatgagacgc 500401 ggctatatgg aaatggcgaa aatcaacctg aatatttctt ctgaggctca ctttgcggag 500461 tgcgaggctg aaacgacagt tgagcgctta gtcagcggag gataatcatt tgattgtgaa 500521 acgcggcgat gtttattttg ctgatttatc tcctgttgtt ggctcagagc aaggcggggt 500581 gcgcccggtt ttagtgatcc aaaatgacat cggaaatcgc ttcagcccaa ctgctattgt 500641 tgcagccata acagcacaaa tacagaaagc gaaattacca acccacgtcg aaatcgatgc 500701 aaaacgctac ggttttgaaa gagattccgt tattttgctg gagcaaattc ggacgattga 500761 caagcaaagg ttaacggata agattactca tctggatgat gaaatgatgg ataaggttga 500821 tgaagcctta caaatcagtt tggcactcat tgatttttag acatatttgc aggttgctca 500881 aatagagcaa ctttttttgt tttcaaaaaa cataaacgat ataatagtga aataacgaaa 500941 aaatatgttg ttttttattg ggaggtaagc gaatttgatg tcgaaccaga ctgtatacca 501001 gttcattgcc gaaaatcaaa atgaactgct ccaactgtgg actgacacac taaaagaatt 501061 aagcgagcaa gaatcctatc agctgactga ccaagtgtat gaaaatatat ctaaagaata 501121 tatcgacatt ctgctgctgt ctgttaagga cgaaaatgct gctgaaagcc aaatcagcga 501181 actggcgctt cgagcggtcc aaatcggact gtctatgaag tttttggcta ctgcacttgc 501241 cgaattctgg aagcgtctct acacgaaaat gaatgataag agattgccag atcaagagag 501301 cacggaatta atctggcaga ttgatcgctt tttcagcccg attaacacag aaatttttaa 501361 tcaatactca atctcatggg aaaaaacagt atccctgcaa aaaatcgcgc tgcaagagct 501421 gtctgcgccg cttatcccgg tgtttgaaaa tatcactgtg atgcctcttg tcggaacaat 501481 tgataccgaa cgcgcgaaac gaattatgga aaaccttctt aatggcgtcg tcaaacaccg 501541 ttcccaagtc gtgctgattg acattacagg tgtccctgtc gtcgatacga tggttgccca 501601 tcatattatt caggcatcag aagctgtaag gcttgtcgga gcaaaatgcc tgctggccgg 501661 aatccgtccg gaaattgctc aaacaatcgt caacctgggg attgatttat cccaagttat 501721 aactaagaat accctgcaaa aaggaattca aacagcattg gaaatgacgg atcgaaaaat 501781 cgtttcattg ggggaataac attttgagac atccgaaaat cccgatcttg aaactgtata 501841 attgcttatt agtgtccatt cagtgggaac ttgatgacca gacagcatta acttttcaag 501901 aagacttatt aaataaaata tacgaaacag gtgctaacgg agtcgtcatt gacctgacat 501961 ctgtggatat gattgattca tttatcgcga aagtgctggg ggacgtcatt acaatgtcta 502021 agttaatggg ggctaaagtc gtcttgaccg gcattcagcc cgctgtggca gtgacgctga 502081 ttgaacttgg aatcgcgctt gaggaaatcg aaactgcgct cgacttagag caggggcttg 502141 agacattgaa gcgggaattg ggggaatagc gaatgaacga ccaatcctgt gtaagaatca 502201 tgacagaatg ggatattgtg gccgccagac agctgggacg aaacgttgcg aaagaactgg 502261 gtttcggcac ggtagaccag gctagaatta caacggctat ttcagaatta gccaggaata 502321 tttatttata tgccggcaaa gggcagattg gaattgaaca ggtcgcagac agaggaaaaa 502381 aaggcctgaa aatcatagcg gaagaccaag ggccgggaat tcctgatatc cgaaaagtca 502441 tggaagacgg gttttcaacg tctggaggac ttggtgcggg acttcccggg gtcaaaaggc 502501 tgatggatga attcagctta aattccgtag cgggggaagg aacagagata caagccatca 502561 aatggcttcg gtaggaggta agaacgtgga ttttagggag gttattgagc agcggtatca 502621 tcagctgctt agtcgatata tagccgaatt aacagaaaca tctttatatc aagcccaaaa 502681 attcagccga aaaacaatcg agcaccaaat tcctccggaa gaaatcatca gcattcacag 502741 aaaagtgctg aaggagctgt atccaagtct cccggaagat gtgtttcatt cgctggattt 502801 tttaatagaa gtcatgattg gctatggaat ggcttatcag gagcatcaaa cccttagagg 502861 gatacagcag gaaatcaaat cagaaattga aatcgcggca aatgtccagc agacgcttct 502921 cggaactaaa gttcctcagg aggaagcgct ggatatcggc gccatcagtg ttcccgctaa 502981 acagatgagc ggtgattact accactttgt caaagacaag gaatccatca atatcgcaat 503041 cgcggacgtg atcggaaaag gcattccagc ggctttatgc atgtccatga ttaaatacgc 503101 aatggactct ttgccggaaa cgggcataca cccttctcaa gtgctgaaaa atttgaatcg 503161 tgttgttgaa caaaacgttg atgccagtat gtttattacg atgttttatg cgaattacaa 503221 tatggacaag catcaattta catatgcttc agcgggacat gaaccgggat tctattattc 503281 tcaaaaagac aacacgtttt acgatttaga ggccaaagga ctcgttctcg gcatctcgca 503341 ggactatgac tacaaacaat tcgatcagca tctggaaaag ggcgatatga ttgttttatt 503401 ttctgacggc gtcacagaat gcagaacgga aaacggtttc ttggagcgtc ctgatctgca 503461 gaagctcatt gaggaacata tgtgttcctc tgcgcaggaa atggtcaaaa acatttatga 503521 cagcctcctc aaattgcagg attttcagct tcacgatgat tttacgttaa ttgttttgcg 503581 gagaaaggtt taacgtctgt cagacgaggg tataaagcaa ctagtgattt gaaggaaaat 503641 ttgaggtgat acgaatgaat ataaatgttg atgtgaagca aaacgagaat gatatacaag 503701 taaacattgc aggagaaatt gatgtatact cagccccggt gcttagagag aagctcgttc 503761 ctctggcaga acaaggagct gacttaagaa tttgcctgaa agatgtcagc tacatggaca 503821 gtaccggatt gggcgttttt gtagggacct ttaaaatggt gaaaaaacaa ggtggttcgc 503881 tgaaacttga aaatctttct gaacggctga tccgactgtt tgacattaca ggcttgaagg 503941 acatcattga tatttctgca aagtcagaag gtggagtgca atgaagaata atgctgatta 504001 catcgaaatg aaagtgccgg cccaacctga atatgtggga attataagac tgacgctgtc 504061 aggggtcgca agcagaatgg gctatacgta cgatgaaatt gaagacttga aaatcgcagt 504121 cagtgaggcg tgcacaaatg cggttcagca cgcttacaaa gaagataaaa atggggaagt 504181 gtcaatacga ttcggtgtgt ttgaagaccg tttagaggtt attgtggcgg atgaaggaga 504241 cagctttgac tttgatcaaa agcagcagga tctagggccg tacacacctt cgcacacagt 504301 tgatcaatta tcagaaggag ggctcggtct atatttaatg gaaacgctca tggatgaagt 504361 cagagtgcaa aaccactccg gcgtcaccgt agcgatgaca aagtatttaa atggggagcg 504421 agttgatcat gacacaacca tcaaaaacta cgaaactaac taaagatgaa gtcgatcggc 504481 tcataagcga ttaccaaaca aagcaagatg aacaagcgca ggaaacgctt gtgcgggtgt 504541 atacaaatct ggttgacatg cttgcgaaaa aatactcaaa aggcaaaagc ttccacgagg 504601 atctccgcca ggtcggcatg atcgggctgc taggcgcgat taagcgatac gatcctgttg 504661 tcggcaaatc gtttgaagct tttgcaatcc cgacaatcat cggtgaaatt aaacgtttcc 504721 tcagagataa aacatggagc gttcatgtgc cgagacgaat taaagaactc ggtccaagaa 504781 tcaaaatggc ggttgatcag ctgaccactg aaacacaaag atcgccgaaa gtcgaagaga 504841 ttgccgaatt cctcgatgtt tctgaagaag aggttcttga aacgatggaa atgggcaaaa 504901 gctatcaagc cttatccgtt gaccacagca ttgaagcgga ttcggacgga agcactgtca 504961 cgattcttga tatcgtcgga tcacaggagg acggatatga gcgggtcaac cagcaattga 505021 tgctgcaaag cgtgcttcat gtcctttcag accgtgagaa acaaatcata gaccttacgt 505081 atattcaaaa caaaagccaa aaagaaactg gggacattct cggtatatct caaatgcacg 505141 tctcgcgctt gcaacgcaaa gctgtgaaga agctcagaga ggccttgatt gaagatccct 505201 cgatggagtt aatgtaatga tccaggttga agaaaacgag catattcaaa ctctagtata 505261 tcaactgaat aaagaaggga aatcgatttg cggtgacagt ttttttatga aagctgatga 505321 taaggagtta atttgcgcgg ttgctgacgg actgggaagt ggatcacttg ctaacgaatc 505381 ctctgcagcc atcaaagact tagtggaaaa ctatgcgagt gaagacgtag aaagcattat 505441 cgaacgctgt aatcaggcga tgaaaaacaa aagaggcgct acagcatcta tcctgaaaat 505501 caattttgag caaaggcagt ttacgtactg ctctgtcgga aatgtacggt ttattctgca 505561 ttccccgtct ggtgaaagct tttatcctct gccgatttcg ggctatttat caggcaagcc 505621 gcaaaaatac aaaacgcaca ccgccaccta tgaaaagggt tcaaagttca ttatacatac 505681 agatggactc aacgtacctg atatccgctc ccatttgaaa aaaggccaat cggtagaaga 505741 aatatcgaat tcgctgaaaa tgtatacgac atcgagaaaa gatgacctga cctatattct 505801 cggacagctg tcctaaaaaa ccagaaaaag aagctggaca tccggcttct tttttttgcg 505861 gttgactatt aataagtgcg cttattatac ttaataagtg aacttatcat tctgggagct 505921 tatgggatgt ggaattatga atacacagcg atagctgatg tggatgtggg aaaacctgga 505981 actgttatca ggaaacagaa acaatggatc aatgggagac gggtattgca tcagattctt 506041 tgaaaggaca atttcaaaat ggaacggaag gaacattgct tctgcaagga aaaacaattc 506101 tcttatggct tgagcatgtg gagaaacatc gggcgttttc tgtcatggtc aacatgcccg 506161 catagcaatg taataatgga gttttttcac gtgcttcaaa agcaaaaaga agatttgtgt 506221 atcacatatg gaattgtatt agaaggcgct gaagcaaaaa agtggggaga aatcattggg 506281 actgaactgt ctaaagacat gccgacggct gtcagcaggc ttgtccatct ttacggagga 506341 gtgataaaat gaacacaaat tactggatcg gcgttgtgtc agagcaacat gtattaaaag 506401 gcgctgccgg cggttttgca cagctgtgcc atggaaaaaa agccccgctc gccaaaatga 506461 aagagggaga ttggctgatt tattattctc cgagagacgc atatccagac ggcaaactgc 506521 tgcgaagctt tactgcgatc ggcaaagtaa aaagcggaaa catctatccg tatcaaatgg 506581 ctccgaattt tattccatac cgattagata tagactatta tccatgccat aaaatcggtt 506641 tttacgacat taaatcaaag cttgaatttg ttcaggaaac caagcatctt ggctttttat 506701 ttcgcagagg acactttgaa ataagcaaaa aagatttttt gacaatagca caagcgatgg 506761 gagttaacat aagtggaatg gcactctaaa tttagcggtc cgaacacaag cccgggcttt 506821 ttattatggc aggccacgca aagttggcag cggaaagtag gaaaagcatt ggctgagttt 506881 gacctgaccc acgttcaatt tgttctgctg acctcgtgca agtatatgat tgctcacgga 506941 gaaaccgtca cgcaaaaaaa acttgcaagc ttcagccaga ccaatatcat gatggtttcg 507001 gaggttgtgc ggacgcttga gaaaaaagga tttatcgaaa gaagcaaaaa tccccaggat 507061 aaaagagagg tcctcctgtc tcttacagaa ataggaggag aaaaagtaac agcggctttg 507121 ccaattgttg agaagattga tcaagccttc tttgcagctg cgatgaaaaa agagaatttt 507181 ctgagcggct tacaggaact attgaaacat gagtaaagat acgggcagcg ccagctgtct 507241 ttttttatgt gtttttttcg gtttttgata cactagagaa agaacgacaa aattggaggc 507301 tttggttaca tggaaacgtc agccctttta aaacagcaaa ttgcgaaaga aataggttta 507361 tcacaaaaac acgttgaaag tgtcatccgc ctgcttgagg acggcaatac agtcccgttt 507421 attgcccggt atcgaaaaga gcagacgggt tcaatggatg aggttcagat tcagacgatt 507481 tctgaacgct ggcaatacat acaaaacctg aatcagcgaa aagaagaagt catcaggctg 507541 attgcagagc aggataaact gacagataat ctaaaacgta aaatcgagca atcggtgaag 507601 cttcaggaag tggaagacct ttaccgccct tataaacaaa aacgtaaaac aaaggcgaca 507661 gtcgccaaaa gcaaaggcct tgagccgctt gccgactata tcctgacact tccccaagat 507721 gatcatctgg cagcaactgc agaccaatac atcagcgaag aaaaagaagt gttcacacga 507781 gaagaagcga ttgaaggcgc caagcacatt attgcggaac aaatctcaga cgagccgacc 507841 ttcagaaagt ggattcgcca ggaaaccttc aaaagaggaa ccattaagtc tgcagccgga 507901 aagtcggcag acaccgatga gaaaaatgtg tatgaaatgt attacgagta tgaagagcca 507961 attgcaaaag ttgttccgca tagggtgctg gcaatgaacc gcggcgaaaa agaagacatt 508021 ttaaaggtag cgatcgaacc gcctgcggat cacattaagg cgtatttaga aaaacaaatc 508081 atcaaaaatc gctcaacatc cgtaagagag attttgcagg agacaattga agacagctat 508141 aaaaggctga tccagccggc aatcgagcgt gaaatcagga aagagctctc agaaaaagct 508201 gatgaacagg cgattcatat tttctcagag aacttgagaa agcttctttt gcagccgccg 508261 atgaaaggca aaaccgttct cggtgttgac ccagcctttc gaactggctg taagctcgct 508321 gtgtcagatg agaccggaaa agtcttgaaa attgatgtga tctatccgca tgcgccagtc 508381 aacaaaacaa aagaagccca tgaaaaagtg aaaaagattc ttgagcagta tcaagtcgag 508441 atggtggcga tcggaaacgg cacagcatcc agagaaacag agcaattcat cgtcaatgta 508501 ctcagagaca tgccgcgcaa aatttattat gtgatcgtca atgaagcggg agcaagcgtc 508561 tattcggctt cagagcttgc cagagaagaa ttccctgacc ttaaggttga agagcgcagt 508621 gccgtatcta ttgctcggag acttcaagac ccgctcgcgg agctcgttaa gatcgatccg 508681 aagtctgttg gtgtcggaca gtatcagcat gacgtcagcc aaaaacgctt aaatgaatct 508741 ctgcggtttg tcgtcgaaac tgtcgtaaac caggttggag taaacgtcaa cacagcctcc 508801 gccgcgctgc ttcaatatgt agctggatta tcgaagtctg tagcaggcaa cgttgtcaaa 508861 aaacgtgagg aaatcggaaa gttttcaaat cgaaaagaac tgaaggacat cccaaggtta 508921 ggtgcgaaaa cctatgagca atgtatcggt ttcttaagag tgcaggaagg gacagagcct 508981 ttggatagaa caggcatcca cccggaaagc tataaagaaa caaaagcact tttgaaaaaa 509041 ctcggacttt caacagaaca tatcggcacg gcggaattga aggacaaaat caatcagctg 509101 gcgctctctg aaacggcaaa agagctggga atcggcgaaa tcactctgaa agacatttgt 509161 gaacagctga caaggccgga acgcgatcca cgcgataagg tgcctaagcc tttgctgaaa 509221 acagacgtcc ttcagctgga agatttgaaa gagggaatgg aactgcaggg caccgtgcgc 509281 aatgtagtgg acttcggagc gtttgttgat atcggagtca aacaagacgg gcttgtgcat 509341 atctcaaaat tgagcaatca attcgtcaag catcctcttg atgtcgtatc tgtcggcgat 509401 attgtgacag tttgggttga cggcgtagat gtacaaaaag gcagagtatc gctgtctatg 509461 gtaaaataaa agcactgctt acgagcagtg ttttttccta tagaaatacc agcattgatt 509521 cagcagttta atttggtaat tatctttttc aaggaacgct ttttgcatct gctttttaag 509581 ccaatttggc ataggctcat tcctcctcag cttttatcat aagagggaca gtgattacca 509641 tattgtatgc gaacggtgaa ttgtcccgtt caatgttttt taagtgaggt gcaccatgga 509701 taacaaagag cttcaaaagc tgacagagga tatttctgaa acatatttta aaaagccgtt 509761 ccgccatcag gcgcttttta atgaccggct taaaaccact ggcggcaggt acctgttaac 509821 ctcccataac attgaattga acagaaaata tttgattgaa cacggcaggg aggaactgat 509881 tggcatcatc aagcacgagc tctgccatta tcatcttcat cttgaaggaa aagggtacaa 509941 gcacagagac agagatttta gaatgctatt gcagcaggtc aacgcgccga ggttctgtac 510001 accccttaag aaaaaagcgg aaaacaaaaa aacttatatg tatatctgta cgacctgcgg 510061 ccaacagtat ataaagaagc gcgccatgaa ccctgacaga tacagatgcg gaaaatgccg 510121 cggaaaaata aaaagaattt tttcgtgaaa aaggttgacg aatatggcaa gcctatgtta 510181 cattataaaa gtcgtcacga gagataaata aaaacattta cctcttgaca ctgcaaatca 510241 aggctgatat aataagtctt gtctcattat tccacagtag ctcagtggta gagctatcgg 510301 ctgttaaccg atcggtcgca ggttcgaatc ctgcctgtgg agccatattg gagaagtact 510361 caagtggctg aagaggcgcc cctgctaagg gtgtaggtcg cgtaagcggc gcgagggttc 510421 aaatccctcc ttctccgcca taagatttcg atataagttc tcaaccatcg gcccgttggt 510481 caagcggtta agacaccgcc ctttcacggc ggtaacacgg gttcgaatcc cgtacgggtc 510541 attccatttc gttgggctat agccaagcgg taaggcaacg gactttgact ccgtcatgcg 510601 ttggttcgaa tccagctagc ccagccattt ttatttttga aatctaatag taagagccat 510661 tagctcagtt ggtagagcat ctgactttta atcagagggt cgaaggttcg agtccttcat 510721 ggctcaccat ttgtcttttt gcgggtgtgg cggaattggc agacgcgcta gacttaggat 510781 ctagtgtctt acgacgtggg ggttcgagtc ccttcacccg cactttattt acaaagtgca 510841 cgcaaatctg ttttactagg ttaagagcct actaaaccag cacaacacaa tttaatgatc 510901 acgcggtcgt ggcggaatgg cagacgcgct aggttgaggg cctagtgggt gaataacccg 510961 tggaggttca agtcctctcg gccgcatctc aataatacca agggtttaac cacctttggt 511021 attatttttt tgtgtggaaa atacggctat gggagaagac ttgctcacca aaactcacca 511081 gttacttaaa gtaagtcatc caaacggtcg gcggttcctt ctgtttatta ggaaaaagat 511141 atccgttcat tgtaaaagaa acgaaccatg tcctattcgt tcaaaaaaac taaagggtga 511201 tacatattat acatgattaa tatgtatcac ccttttcttt cttgttcaac aatcgcgctt 511261 gaggagaaca taagctaata caactgactc gatttctaaa gttgctccat tcttttttta 511321 aacaactcat ccacaacctg ttttaaaatc tcgtacgact gaatttcctt gctcaattcg 511381 taaatattag ataacacaat taattcatct gcgtgataca tttgttggaa atcaattagt 511441 tcgcgacgaa ttgtttctcg atcacccatg attgtatacc ccagtcgact gtggagaatt 511501 tctaattcaa actgtgataa cgattctagg aagttttcag tgggtggaat aagcttactt 511561 aaattatttg tataaatatc aatatacacc tgcaaatgac ttgcagaaat aaaagatgcc 511621 tcgtctatag attctgctgc aatcacatta atgcaagcga tcacataagg ttcttgtaaa 511681 taagaagacg gttggaaatt ttctcgataa atagagagcg cttcttccat cgaatggggt 511741 gaaaattgag cgccaaatgc atagggtaaa ccaagctttg cagcaatttc cgctgaatcc 511801 gttgaggatc ctaacacaaa aacaggcaca tgcgttccaa tacccggata agcgcgaacc 511861 tcaccctgta cactcttatc cccgacaaaa cgcaaaatat catttacttc tctttcaaag 511921 aaaaacactc cattatggtt ggaacgacga atcacatcgg ccgttttttg atccgttccg 511981 ggtgcgcgtc ctaatgccaa atctacacga tttggatata atgtttcaag tgttccaaat 512041 tgctccgcta cgattaatgg ggaatgattt ggcaacataa taccccctga acctacgcga 512101 atgtcttttg tatttgctaa tatatgttgt acaattgata cggttgctgc acttgcataa 512161 gcgtcgtgat tatgatgctc tgcaaaccaa atccgtttat agcccatatt atctacagct 512221 ttagctaatg acactgcaga atcaatccct tgtttcattg tttctccttg tcttaatgga 512281 gcaactgata aaacagatat atcaaatttt ttcataattt cacctctaaa ataatgaact 512341 tatacaagat caatggaaaa aacattttga aaaattgttt catattaaat ggtgtccatt 512401 cctctttgat ttgcatgcaa ataaatatat actttctcaa acgatcaata cataggcaaa 512461 ataaagttat ttcacaattt cactttactt ttaaagtttt aagcaaacat aaaaaaatgt 512521 tcagtgaaca aaatatgtaa aatacatctt atttttcaga aaggatacaa gaaaatgatt 512581 gatgaaatag ataaaaaaat acttgatgag ctgtctaaaa atagtcgcct tacaatgaaa 512641 aaattagggg aaaaagtaca tctcactgca ccagcaaccg catcaagagt agtaaagtta 512701 atagacaatg gcataataaa aggatgtagt atcgaagtga atcaagtgaa attaggcttc 512761 tctatacatg cttttcttaa tatttatatc gaaaaaatcc atcatcaacc ctatttagct 512821 tttatagaaa cacaagataa ctatgtaata aacaattata aagttagtgg agacggttgc 512881 tatttgcttg aatgtaaatt tccttcaaac gaggtattag atcaattttt aaatgactta 512941 aataaacatg caaactataa agtgtcgatt gttattggta aatagttaac tttataaaac 513001 ggagatgtgc ggtcatataa catgatatat atgctctaaa aaagccctag gttggatatg 513061 gaatttacca agctggggcc tttttataca ttataataac aagcgcatta ttcatcagac 513121 attaatgaag tattataatg cttttttact tccttaatag acaaataaag ctgatagttt 513181 ccatacttca ataaatcatt cagaaggtga tttaaaactt cttgtgaatg aaccgttacc 513241 ttcagaagat aacatgcatc tcccgaaaca cgatgagctt cgctaatttc attacgagta 513301 gcaataaatt tcaataaatc atcatgcata tatgcattca tgaaaaagaa gacaaaggct 513361 gtaaaagaaa accccatctt caattcatca accacaatcg aatatgcttt aatgataccg 513421 ttatcctcca tttttttgat gcgattgcct accgcttgtc ctgtcatatg aattttttca 513481 ccgatttctt tccattgtat ccgagcattt ttatttaata attggagaat ttgaaaatca 513541 attgaatcaa tttgcatagt aactcctttc acagtgaaaa agttttacaa aatagtattt 513601 catgagacca tcgaaaattc aatggaaatt atatatcctt atacagtata aaaattttaa 513661 gaggtgaaaa aatgacaaca gctttattag tgattgatat tcaaaatgat tactttccaa 513721 atgggaagat ggctttaaca aacccagaga aagcagcaca aaatgcggct aaactacttt 513781 cacactttag aaacacaggc gcacctgtct ttcatgtaca gcatatcaca gaaggtaaca 513841 tcgctcattt tttccatcca aatacagaag gtgtcgaaat tcatgagtca gtacgtccat 513901 tagagaaaga gacagtcatt gtaaaacata tgccgaatag ctttttcaat acagatttaa 513961 atggaaagct acaagaagaa ggggttaaag aattagttgt ttgcggtatg atgtcccata 514021 tgtgtattga tgcaacagtt cgttctgcag ttgaacatgg ttatgtatgc caagtggtag 514081 aagatgcttg cgcaacaaca acattgcaaa ttgaagataa aatcgttcct gctgagcatg 514141 tccattacgc atttatggcc gcattaaatg gtgtctatgc aacagtaaaa accacagagg 514201 catttttaaa ataaaagaat ttcctgcgcg aacataacgt ctttcttttc acaagaaaga 514261 tgattcaaca acttaaaaaa ggatgttcag aaaaatactt ctggacatcc tttattcatt 514321 atcttttatt gtttttcagt atcattattc ccatctgata aaagatcaag atgtcctgtt 514381 tttgatccat agtaagacca tatacaggga ttgtttttgc cataaatata gatattgatg 514441 aaggtttaca taaagcacct aattgcttga tttactttaa tgttagatcc ctcaataact 514501 ccattctctt ctaatttctc tactctagct gtagctgctg ggcatgttaa atgtactctc 514561 tcccagatct ttcattgaat tcggctatta tacataattt ctctataatt ttttatctgt 514621 ttgatctatt tgaacgttaa ttcctttcga aaataaagtc aaagagttaa aacacttttt 514681 tttatctatg tattcgaaca ctgctgatat tatacactta actctgtcga tctaagacaa 514741 ataaaaaaag aaagtgagtt gtaaatatga atattacaca aattcgaaat gcaacaattg 514801 ttgtaaaata cgcaaataaa aaatttttga tagatcctat gttagcagag aaaggtacgt 514861 acgctacttt ccctgaaacg atcagacaag atttatttaa tcctttggtg agtttgccaa 514921 catcaattga taacattctg gatggcgtag atgcggtaat tgttactcat ctacacctag 514981 atcactttga tgatgtggca aaaaacgtat tgccaaaaaa catcaaaatg tttgttcaaa 515041 atgaagcaga tgcaaaagaa gtaaaagcaa gtggtttcaa aaatgtagaa gtgctacatc 515101 aagacactgt ttttgaaggg atccaattag taaaaacaaa aggtgaacat ggcagagggg 515161 aagagttatt aaacttaatg ggtgatgttt gtggattagt attcaagcac ccaagtgaaa 515221 aagttttata tgtagctggg gatacagttt ggtatgatgc tatcgaagac gagattcata 515281 cacatcaacc agaaatcatt gtggttaatg gtggagacaa tcaaagatta gatttaggtt 515341 cactcatcat gggaaaagaa gacatctatg aagttcacaa ggctgctcct catgctaaga 515401 ttatatctgt tcatatggaa gctgttaacc attggacact atctagagaa gaattaaaaa 515461 actttagtaa agaaaaagga ttctcaagta atattttagt gccagaagat ggcgagtctt 515521 acacatttta atatgaacac cgacaaataa atagaagaag ctcataatta taaaaactaa 515581 tcatgagctt cttctaataa tgaatatttt aaattttaaa tatatcgaaa atcctaaata 515641 tacggaataa caaaaatgga atgttccaat gatgacaaaa aaacttgaaa agcaacaaag 515701 atgtgtcgtt aggaggtaga attcatggta atgacaaaaa aagatacaaa tatatcaaca 515761 cagcagcctc tttggttaca aggttatatt gattcaccag aaaaacaaaa ccaactttat 515821 aaaaaaacat taaaaatctt gattttttca caaatatttg ggggagcagg acttggagct 515881 gggataacag ttggggcgct tcttgcacaa gatatgatag gatcggaaaa tgtagcagga 515941 attccaactg ccctctttac ttttggatct gccgtagctg ccctgcttat aggagcatcc 516001 tcacaacgtt ttggtcgcag agctggactt gcaggtggtt tccttatagg cggattaggt 516061 gctataggtg tgataatcgc ggctttaatt aacagcgttg ccctattatt tgtttctctt 516121 cttatttatg gagcaggtat ggcttctaat cttcaagttc ggtatgctgg gacagacctt 516181 gcaaatgaga aacaacgggc aactgctgca agtatggcct tagtttctac tactttagga 516241 gctgtagtag gtcctaactt agttaataca atgggggaat ttgcagattc aattggtgtt 516301 cccaatttag ctggtccgtt tattatgtca ggagcagctt ttataattgc tggaattatt 516361 ctcttaattt ttcttcgtcc agatccgctg tttgtatcaa cagctattgc gaatgctgag 516421 aaaaaagacg ataaagtaca aataggagga agtctaaaaa atcctgctat agacaaaaaa 516481 ggaataatgg taggagctgt cattatgatt ttagctcaac taatcatgac agctattatg 516541 acaatgacac cggttcacat gggtcatcac ggtcatggtt taagcgaagt gggattagtt 516601 ataggactcc atattgcagc gatgtatctt ccttcaccat tgactggttt attagtagat 516661 aagtttggtc gcacaactat ggctattgct tcaggtgcca cacttcttgc cgctgggttg 516721 gtggcagcta ttgcaccggc agactcatta tcattgctaa tcctagcact agtattacta 516781 ggggtaggtt ggaactttgg tttactaacg ggaactgccc ttattataga ttcaacacat 516841 ccatctctac gtgcaaaaac acagggaaca ttcgatgttt tattagcact atcaggagca 516901 gcaggtggag ccttgtcagg aatggttgtt gcacattcta gttatacaat actatcaatt 516961 tctggagccg ttttatcatt gttactcatt ccagtagtta tttggtattt tagaaggatt 517021 caggaaaaag cataagctta tataactgtc tttgaagaac ctaagtagac attactttac 517081 cggaacctcc tttttctatt tattatagta aggagttgac atggcattag tggcatgtgt 517141 ataactacac aattatttgg gattcagaga gcatgtaatg aacggaagag ataattattt 517201 atcactttta ttattgtacg gtgttcttgt ggcattaagt tcagtcaatt ttggtctaac 517261 tgttttcttt ttgttttcat cacctctcca tattattaac aaacacgaaa aggattttaa 517321 tgaaaataaa atgattagcg tatgtatctc taattttcaa aatgaatgaa tagtcctttt 517381 taagatttac acacttattc tccaaggaaa aatgactcaa tttttcgatt ttttatgtaa 517441 atcaaaaaag aatcatgtta gagtaggtgt gctgaaaata attcaaaaaa ttattttgcg 517501 atatgattaa agtaatattg ccagagagtt tcaattggac aaaattgtaa gtgtttaata 517561 cactggggct gcaatcaaat atgcacctgg aatcaattgc taaacggggg agtttatatg 517621 aacaacaaga aaaatatctt tgatattgtt atgtacatta ttttcggtgt gttaagtctt 517681 tttctagttg caaaaactga ttatggcact ggagttttag tgtttgttgc aattttatac 517741 ctcgctgtta ttgcttataa aattaagcaa gtatttagta attcagattc ttaaggtgta 517801 acacaaggag gatttcaatt gagaaagaaa agagttatta cttgtgttat ggctgcatca 517861 ttgactttag gctcactttt acctgcaggt tacgcttctg caaaggagga ctctaagaca 517921 accccttctt acgaagaact agctctacat tacaaaatga aaagtgaaaa gatttcatcg 517981 aacgggaaat tagttgaaat tgagtatgtg agtggaaatg aaactcacaa agttcagatg 518041 aacggaaata atcatactgt aaaagtcgat ggcatagaac aaaaaggttt aaactttgag 518101 tatgatgaaa atgttgctaa aagaacaaat tatgaaaaca ataatttgaa atcaaatgaa 518161 ttcacaacac aggctgcaaa acctaaaaag ggataccatt atgtggggac tttatctggg 518221 catacaaaag cagctaaaaa tgcgttatca gttacaatgt cattagtcgg tattgtccct 518281 ggcttgggat gggggagtaa ggctgccact attttattct cttattgggc aaaagaacaa 518341 atccctgatg cgtattataa atatgattta tacgaaaaag gagcaatgac tgatagttgg 518401 tatcagtatg ctacagttca attttttgaa gataaagctc ataaaaagaa aatgggcaaa 518461 ccttggacaa gtactcctgc aaaagtagat ttacctaata gctaatttta aaatcacttt 518521 gtctttataa aggacaaagt gattttttgt tatacagaag taaaatccct cgtctgagga 518581 atcttggaaa aaacttggtt caattttgat ataacatgtt tttttcttgc taatttagtt 518641 tttctatgta tcgctacaca ttctaaataa taagatatta gccggacggt tgatgccaag 518701 ctcaaaagtt tatatggaag tcaaagcata aaaaagggtg ttacaacgtg tagtcttctt 518761 tttattttgc caacgtaaca agtgtgaaag taatgatttg taggatcagt taagaaaggt 518821 ttaagattag atattgaaaa attttatata ttttcaataa aatactggta ctataataaa 518881 tgtatacaga ttgtatggag atgtaattaa ttaaaaagga gttttttaat tgcgttggag 518941 taaatggttc aatgtttttt gtatagtagc attgggatca atatatggtt ataaattatt 519001 tactaaccaa gaagtcagta ctactcgttt aataatagct tctgtaattg tgttgtggaa 519061 tattgttgga ctttttagca aagaatcagt aaaacaagca cagcaagcaa attaaaagtc 519121 ataaagttgg gaaagaagga tgttacttat gtagtatcct tctttattat tccttgaaaa 519181 atgaaacaaa ttggagatta cagcttatat aatcaattga agtcgttgat tattttcatg 519241 aacaggagat ttaatgcttt ctgatgaaat attatcgtat gaatgttgca agaggaaacg 519301 ttactcaaag attacaggga tgtgatgaac actcctcttt atcgcactca cctgacccca 519361 aattgttggg gaagggcagg tacggaagat agagtatttt ttcttcgtaa caaatcgaaa 519421 aggttggata ataaaaaact tataatctaa ggcggtatat agttgtgaaa aaggcgttat 519481 ttcttatatt agaccagtat gcagattggg aaggtgttta cttagcatct gcattaaatc 519541 aaagagaaga ttggtcggtt cacactgttt ctttagaccc tattgtaagc tcaataggtg 519601 gttttaaaac atctgtcgat tacataatag ggttagaacc tgcaaatttt aatttgctag 519661 ttatgattgg cggggattcc tggagtaatg acaataaaaa actattacat tttgtaaaaa 519721 ctgcatttca aaaaaacatt ccaatagcag cgatatgcgg tgcagtggat tttttggcga 519781 agaatggttt gctgaataat catagccata caggtaattt tgtttactta tggaaagatt 519841 acaaacaata taaaccgatt agcagttttg tagagaaaca agcagtaaga gataaaaatt 519901 tggttactgc taatggaact gcccctattg aatttactaa tttaatttta gagatgattg 519961 attttgatac tcctgagaac atagagaaaa tgatgtatat gaatcgttat ggtttttatc 520021 atttttgtga taaatatgga aatccatttg ttgattaatt tgctggaaat gattttcccg 520081 aatagggggc tttgcgattg agttgaattt cctaataaag caaagaaaga tgatttgagg 520141 tcaagtttaa caaataatgc catcaatatt aatttgcagt tatttccgat tcctgatata 520201 ataaagaaga attatttttg ttcggtgtaa aggatagtat gaagattgac ttttcgtctt 520261 gatgatactt tgggcaagga tagtatatac tgtgtggtta cacactagga ggcaacaaaa 520321 atggaacaag gtacagttaa atggtttaat gcagaaaaag gttttggctt tatcgaacgc 520381 gaaaatggag acgatgtatt cgtacacttt tctgcaatcc aaagtgacgg attcaaatct 520441 ttagacgaag gtcaaaaagt atcgtttgac gttgagcaag gtgctcgtgg agctcaagct 520501 gctaacgttc aaaaagctta atcttcaatc gtttatacaa acaggctctt tatatagggc 520561 ctgttttttt atgtctatat catactcaat aaaaaaccct actcaacgtt cgagtaggga 520621 gatgctacaa ggtaatagaa aaagatttaa aacttcaaag gtttgtttac agtataacat 520681 actggattga caatatgcgg aatgtatata aattatttaa tgttttgttc aaatatagat 520741 aactgactct ttttttcact aacctgttcg ttcatttaag taagattaga tgaattataa 520801 aaatggtttc atctaaatgt tatcaactcg catatctctt ttatgagaag aagataaaca 520861 attattattc aatgttgcag tggatataag aaattcttaa aaataatgag gagatcgatt 520921 gtttttttct cctggaaata atcacttaga gatacctaaa acaatgaaag ccctacctct 520981 cttccatcct tacggctcct tgtccgtgcc agtgtgaatc aggatactaa aaaaagtgac 521041 tattttattg agttttttgg taaaacttca atcttcgcag aagaaatgta aataataaaa 521101 atggattaga atgtaggaat aacaaaagag gtcgttaatg ttctaaacat aagttggaga 521161 agatttgctt ttcatcataa tattccgaaa tatcttttgg gatgtatcta accaaaactt 521221 tttatttgtt tttcagtgat tcctttaatt acttccagtt cactaatcaa aaattcatat 521281 gcattatcca gcattttttt ttcgcttgca ttaagtgctt tttctttctt catacgcatt 521341 aaatcacgta caacttcagc accttcttgt atttcacctg tttttatttt gtccgtgttt 521401 attttgtacc tttgcttcca tggcagtaac ctatcggatt ctccatgctg aaaaatgtgc 521461 ataatgtgtt ttaatgcaag tatatcggta actggtcgta tattcgaact caatatttta 521521 ctcgttggaa tcataactgt catattactg attgacattc ttatgacata atactgttgt 521581 ttttcctcta agaattcttt ttcttctatg gcttcaatta tacctgctcc gtgcattgga 521641 taaacaatgt tatcgccaat ttgaaacata tcatccacct ccatatatgg tatccttctt 521701 aagattacca tatatggagg tgtaatatca aaattttaat aataacatga tcgaattttt 521761 gatgtcaata acttttttga aaaaacagat caagcaaaaa caatagggaa cgtgtcggat 521821 ttccaatcag gaaaaggtca attgatccgt gtgagcagtt tttcattggc tcaatgacat 521881 tacagaaatg atttgagtag ataagaaaga acgatattcg tgaaatgtca gctaaaaata 521941 tttaaagcac atgattaagt tctaatttct ttaccgattt gatatggata acggccgact 522001 tacttaatga tgcattttca cttatcttgc aagcagaaaa aggtttgttg ataaacattt 522061 agccaccaaa ttggcattat tatcagggaa attgacaacc ttcaaatggg tattgaggcg 522121 agaagaaaaa taaagaaagg agagattata aatgaagacc agaacataaa gaagtaaagg 522181 ggaaagaaca aggttaattg aaaagcaaac tatataaaat agtttgcttt tttttgttat 522241 gacttcactt ctttttcttt ctctttaatg actaataaaa caccgctcag aattaaaaac 522301 gaacctatcc aaaatgtccc gcctatttgt tctccaagca gaatccatcc gagtaaggtt 522361 ccaaccagag gctgaaaaaa gaaaaagagg cctccacttg aggcatttaa taattgtaag 522421 ccgtggttcc acaataaaaa tgcacaagct gttgaaacaa ttcccaaata caaaaggcca 522481 cctagaattt tagggtcaag cagtagtggc gtaaaaatcg tgctagggga gtaccattaa 522541 cagggactcc atttattaat agaataaact ttatgaattc atttttttgt atgataatgg 522601 cgtcatattc atcgcttgtt gaaatttact tatgaaataa ctggtactgt taaatccaac 522661 ttgataagac acttctgtca cattggattc agggtgttgc agtaataata agcttttttg 522721 aattctataa tccattacat aacgtaatgg cgtcttattc agcattcgtt taaaataacg 522781 gcagcattca gaacggctca gttggccagc ttttgcaatg tcctctaatg tgattttttc 522841 aacataatgg agatggatcc agtttaacat ttgtttcatt cgatgacttt ttatcatttc 522901 agattgatcg tactctaatt gaaaaccatt aacgaccagg tttttccaca ttaacgttaa 522961 ttgcatcgta atgtcaatct catagagcga tgtcttttgt tgaatcaatt gatttatttt 523021 tttaacagca tctagaatat tttttgccca ctgttgattt ccagccaaaa ataaataggg 523081 caaattggtt gaaaacatat agggctgaac atagcttgaa tacagttcct gagataaaac 523141 gaaatggggt gacacattca agcaaatata cgtacaatcc gagccttcct tttcttcggc 523201 catgtgcagg tagccgctat tgataaataa tccatcccct tcgtgaacct ctattttttc 523261 ttcatttatt tgaaagagag ctatcccttt tagtatcaaa acaaattgga tttcatcatg 523321 ccaatgaagc ggaatatagc catttatatt ttgattgatc gttgtcttgt agcaggcaac 523381 tggcaattct accgttcggt gctctgttaa ttcttttaaa ttttgatcga tcacaaaatt 523441 cttcattctg acttcacacc tcaatatatt tatatttttt cattcaattt gagtattttt 523501 tatcatgttt tgcatttatt ataacactat tattatattt attagtgagg agtcatgtat 523561 gaatacttcc aatagaagaa tgggattgtt ctatgttatc acaggggcga catgttgggg 523621 gattggaggc acagtagcca aaaaactttt tcaagaatat caaattgatg tcaattggct 523681 tgtaacgaca cgcttgctta cggctggaat gttactttta atgctgcaac tgttcagaaa 523741 ggatcgttcc caggttattg aggtgtggaa acacaaagcg tcggctggcc agcttctaat 523801 ttttggccta ttgggaatgc tagctgtgca gtacacatat atggcatcca ttcaacatgg 523861 gaatgctgcc gttgctacgt tattgcaata tttatcccca gtaatcgtca ttatctacac 523921 gctgttgcga aaacaaacgg ttcttaccaa acaagatatc ataactgttg tacttgcttt 523981 agtgggttgc ttttttttgt taacaaatgg ttcaatgtct caactttcag tgccggcagc 524041 tgcagtagta tggggagttt tatcaggatt cgcggcagct ttttatactt tgtatgccgt 524101 tggtttatta aataaatttg attctcttgt cgttgtaggt tgggctatga ttattggcgg 524161 ttttgcattg ggttttatcc atccgccatg gcaactggat tttcaacgat taactgctga 524221 ggcgtatgca tatatcttat tcgtgatatt atttggaaca atgattgcgt tctggttctt 524281 cataaaaagc ttggaaagcc tctctccaaa agaaacaagc ctactaggca gtctagagcc 524341 tctatcagct gttgtaacaa ctgtcgtttg gttaaaagcg ccatttggtt cttttcaatg 524401 gattggtgct atttgtatta tagggataac tttaatattg gctttacata aagagccttc 524461 tatggagagt gaaaaatcga tattaaagat taggaatcat gcaaatcggg atatataggg 524521 gctttttttg cttacatgac cggtccggca atgaaaaaca ctggtggagt ttgagccctc 524581 tcggcagtat caaaaatacc aagggttttg acgccctagg tattttttct tcaagaacct 524641 tcaatttttc ttctctgatt gaaaaacgta ttactttttt gtgattggta tccaaatttc 524701 acttttaaaa gatggtgatg ttacatcctt atgctcgttc cacaatattt ctggaccttc 524761 tatttgttcg taatttgacg atggaaacca ttcggaataa atgcgtcccc atacttcttg 524821 cagtgtatcc ggaaatggcc cgattgattc gaatacagcc catgttgagg caggaacttc 524881 aagccgtgag aagttatctg gacaccgttt cgttgtggct gcgccaatat agtgatcgag 524941 ctctccgttt tcctctgtcc gaccttcaga aaaattcgtg gatgcactaa tgaggcctga 525001 tggtgctaca ttagatagct cttttagttt atttattgct ttttcatcta aactttccca 525061 catagatgca atttccggat taattccttt gaaaataata ggaactcttt ttttaatgcc 525121 aacgatgcga aatgcctctt tttcttcaat acggtagttc atttcatttc ctcctttaat 525181 tgttagctgg aaggtcattc gtggataagc tttaagggaa tggccattaa atctggcttt 525241 tgatgggttt atgccatgta aattttggaa tgcccgtgca aaagaatctg gtgagttata 525301 accgtacttt attgcaatat caatcacttt tacattgctg tctttcagtt caaaagctgc 525361 aagagtaaga cgtctgcgac gaatatattc cgataatgaa atacctgcaa ggaaggaaaa 525421 catcctttta aaatgatatt cagagcagaa agcaagcttt gctgcctctt gaaaatcaat 525481 atcattagtg aggttttctt caatatactt taacgcccta ttcatacttt taagcaaatc 525541 catttatttg gcctccttta accaaagaat aacaggagtg aaatgtattt atccgacatt 525601 ctgtgcacag ttttgcagga tgacttatat gaaataaagt aagtgattca cttgtatttg 525661 tacaggtttt attgaagcat gctgttcata aaaaggcatc aataaaagaa agttataatt 525721 gtcttataaa cggcacattc atataattga gtgaaaaagg atgcgtatca tgcctatcaa 525781 ttcttttgaa aattatccga tgagctggaa gccatcgatt gataaagctg aaaagcctat 525841 ttataaagca cttgcagggc aattggaaca ggatatttta aacggagttt tattacctgg 525901 aacaaaactt cctccacagc gagaattggc cgattatcta gatttaaatg tgagtacgat 525961 ttcaaaagca tttaaagtgt gtgagttaaa agggctgctg agtgcgactg tagggagcgg 526021 cacatttgta tcgtatgatg cgttgtcgaa tgcgtattta cttgaggata ctaagccgac 526081 acatttaatt gaaatgggag caatacttcc agatcacgct tcatatgagc ccttgttata 526141 ccaactgaaa aacatggttc atgaggagga ttatgaaaaa tggtttagct atggccgggc 526201 aggtgaaagc ctttggcaaa aagatgcagc tgtaaagctc atccaaagag gcggatttga 526261 aacatccgtt gatcacattt tatttgcaaa tggagggcaa aatgcgattg cagcgacatt 526321 ggcgagtctt tgtaagcctg gagatcgcat cggagttgac catcatacgt accctggatt 526381 aaaaactgtt gcatcattgc ttagtgtgca aatcgtaccg ataaaatcag aaaacgatga 526441 aatgagtccg gagtcacttg aatatgcgtg taaaaacgaa aatattaaag gtttgtattt 526501 aatcccggat tatcataatc cgacgacttc ctttatgtct gttgagaatc gaagaatggt 526561 tgcagacatt gtaaagaaat ataatctgtt tgttattgag gatgcatcgt accatcttct 526621 caacaaaaat ccgcttccgg cactcgcctc attcgcaccg caacaggtta ttcatattgc 526681 aagtttatca aaatcgttag cgccaggcct gcgtttggct tatgtagcag tgccgagaca 526741 atataaggag ccaatatcaa aggcgcttta taatttaaat ataactgttt ccccgctatt 526801 agctgaactt actgctcgca cgattgtatc aaatcaattt gaagtcttaa ttgagagtca 526861 tcgtgaacaa accattcgca gaaatcaact cgtaaaccga tatgttgcgg gatatacatg 526921 tttaggtgtt gaaacaggca tttttcgttg gttgttgtta ccgggtaaaa tgtctggtgc 526981 cgaatttgaa gaattggctg ctcgacttgg cgtgcaagtg tatgcggctg aacgctttgt 527041 agtgggaaat agttgtcctg aaagggctgt aagggtttct gtctgtgcac caaaaacact 527101 tgaagagctt gaacaaggat taatgatcct gagacgtttg ctagacgatc ttacctaata 527161 ttgtttgcca tacaattatg acattgtatg gcttttttgt gcgtgttatg atgatccaca 527221 tctagaggga ggtttataca aaattggctt ttagaaagga aggtcagatg atgttagaca 527281 aggacagcgt aaaagcaata gatgttcaaa ctgcttcatt acagagctac atcagttcac 527341 cagaaaaaca aaaatcgtta tacaagcgta cactattcgt tgtgagtatc tcacaaattt 527401 ttggcggtgc ggggctggcg gcaggagtga ctgtcggtgc gcttattgca cagcaaatgc 527461 ttggcactga tgcgtttgct ggtttgcctt ctgctttatt tactttaggg tcagcaggat 527521 ctgcattaat tgttggaaga ctttctcaac gttatggccg tcgaacaggt ctttcagctg 527581 gctttatgat tggcggactt ggagcaatag gcgttattat ggcagcaatc ataaatagta 527641 ttttcttgtt atttatttcg ttgcttattt acggtgcagg tacagccact aatttacagg 527701 cccgttatgc aggtacagac ttagcaaatc ataagcagcg agcgactgct gttagtataa 527761 ccatggtttt tactacattt ggcgcagtgg caggtccaag cttagtgaat gtgatggggg 527821 atttcgctct ttctattggt gttccatcac ttgctggccc tttcatttta gccgcagcag 527881 catatatgtt agcaggtgtg gtccttttca ttatgcttcg tccagatcca ttagttatag 527941 caagaacaat agaagcggca aatgaagagc ctggtgataa aggacatttg gcggcaactg 528001 agcatacaga aaacaaaaaa gggataatcg ttggggcaac ggttatggtt cttacccaaa 528061 tagtaatggt agctattatg acaatgacac cggttcatat gagacatcat gggcatgact 528121 tgggtgcagt cggtcttgtt attggttttc atataggtgc tatgtatctc ccttcacttg 528181 ttacaggtgt tcttgtagat aggttgggac gtaccgcaat ggctatttcc tctggaacaa 528241 cgttgctttt ggcaggtgta atagcagcat ttgctccggg agaatctatg attcttctcg 528301 tcattgctct ttctttactg ggattagggt ggaattttgg tttgataagc gggactgccc 528361 ttattgtaga ttcaactgat actgccacac gagctaaaac gcaggggaca gtggatgttc 528421 tgattgcgtt gtcaggagct gctggcggag cattatctgg aatgattgtg gcaggttcaa 528481 gttacctcgc attatcactt attggaggga ttttgtcctt attactcatt ccggtggtgg 528541 tatggtctag gggccgctaa agggtaggat tgtttaattt acattaattt gttatattgt 528601 tagataaagt atattgcagc atctaatatt ctaacgaact atagttgctc cattaaatct 528661 attataaaga tttgaccagg attccttata gctgtgtcac tcactgcata ttctttaatt 528721 gaatcacata aaatggttat cggatttgaa aaaggcagga ttactcgctt taggtaaagg 528781 agtcataacg ttgttaaaaa ggttttctct tgttattgtt acactaatga tgtctatcgt 528841 tgttgtttta gcggctgcta aagagtcgcc tggagatcat gtcatctcat ttgatgaacc 528901 tattatcttg atgatctcaa ttggaatcgt tgtattttta ttgatccctc cattagtcat 528961 gtcctttttt ggcaatttgg ttgtaagaat aatatctggt gtataccaat gttttatcgt 529021 tttcactttt ctggggctca ttccaattgg atttcttatt cccaatggct ttttgacaat 529081 tctagtttct attgcaggaa ctttagtcag tatagctagt gttgccgtaa ccttatgcat 529141 tggcaagaat aaaaaagata tataatcatc gaattgttat tttttcagat tgtcagtgaa 529201 ataattatac aaaaagagaa ggcttgtggg ccttcttttt ttgttgttgc atcatcccca 529261 ctttgagctt aatctattga ataataagag aaggaaccta tagaagaata aaataaatac 529321 cgagatgtca aaaataaaac tggacttcat tattgtgaat tcacgtaaat gtaaaaagat 529381 tggaaagagg ggaattcctt catgacaaat agcagaacaa atccgaaggt tgatgaattt 529441 ttaagtaaag cgaaaaagtg gaaggaagaa tttgagaagt tgagaaccat cattcttgac 529501 tgtgagctga ctgaagattt taagtggatg catccttgtt acacatatca taataaaaat 529561 attgttttaa tacatgggtt taaagaatat tgcgcgcttc tgttccacaa aggcgtctta 529621 ttacaggata cagatggaat tctcattcaa caaacggaga atgtacaggc ggcgcgccag 529681 attcggttta caaatgttca ggaaataaat gagctagaaa acattttgaa agcctatatt 529741 cacgaagcca ttgaagttga aaaagccggt ttgaaagtgg atgttaacaa aaatattgaa 529801 ttgaacattc ctgaagaact tcaaaataaa ttcgatgaaa tccctgcatt gaaaattgct 529861 tttgaagctt tgaccccggg acggcaaaga gcgtacactc tttatttttc tcaagccaaa 529921 caatccaaaa cccgagaatc gagagtcgaa aaatatgtgc aaaaaattct cgatggaaag 529981 ggattaaagg attaggcacg ccaaggttca ggctaaagga atagcatcat agcgtaataa 530041 gatcatttct atagaagaaa aacaagcata gtaagatgct tgttttttct taggacaaca 530101 ttcacttact gctgaaatgc ttctaacatt gtatgccact agacagcgtt ataaaatatt 530161 aatgcaacac ctagaaatct atccaatgaa atagctcaat ggtatggctc attacattta 530221 gaatgcctag gagaactaat agaaccggaa gatttttagc aagttactac actccaaact 530281 ttgtttttgt attaatatac cttattaacc attgttttta gtcaggtgca gacaaacgaa 530341 tactgattaa tgaatcatca tgatatcaat gagccgcttg attttttcat cgtcgcctgt 530401 atcaacgtac actgtttttc tgttttttat gatactctca gtcacttccc gcatgacgcc 530461 tttttctata tcatcagcgg aatcccagcg taaaggcaca ttatatacat gaattgtgcc 530521 atccccattg ccatgataag tgactgatcc atccactaaa cgagaacctg ccaactgggt 530581 cacattttct ggatagctgg cacttgtatc atcattagga ttaattggct cgccagccgc 530641 aatatgtcga acatttaatt catctatctc ttgattaggt ccaagttgaa gccaaactct 530701 ggcatattca attttttccg aagagtatgc tgccaataca ttgtcttctt tgcttttctc 530761 ttctgctgaa gaggtatcat ttgcagcttt tgttgcggat tcttctgatt ctgttattgg 530821 ctccgcttca tccttgcgta ttttggtgct ctcttcaggc tcagtgtgtt tttcgtcagt 530881 ttgcacagca gaagcttgat ttgaaggttg ttgtgcttct ccatccttac tgtccgtaca 530941 tccagcaagc aaaatcataa gcagcagggc agtattgcaa taacatatct ttctgcgttt 531001 cttcattttt tcattcctct ctattaattc aggtcagctt catatataag tttatgtatc 531061 taaatattac catggaatag ataggatgat attgaaaact gtttaagaag aggaaacgat 531121 cttgaatagc atcgcgaaaa cctaagaatc ttaagaagtt ttgccccttt ttcttcaggt 531181 attgaatgta aagtgggata taaatgcaaa caaaaacgaa atgccttatc cacctcgtgt 531241 catggcagaa aaagtggggg atttattaga gcggatttga taatggcggc aggtaaatgg 531301 gtgttgactt atatgtctaa gcgggagact caagtctgct cgatcgcata caaaatacca 531361 agggccagca acccttggta tttttatacc ttcatgcatt tttgaagttt atgcttaaag 531421 gtctgcctta ctttgcaaat cgccgagctg ctgcaacgca catgataacg gcgatattca 531481 ctgctacgag tgcccagccc actttctcgt gcagaatcac tgaggcaagc agcagtccaa 531541 aaaaaggctg gagaagctgg agctgcccaa ccgctgcaat tcccccttgg gcaagacctc 531601 gataccagaa cacgaagcca atcagcatgc tgaataagga tacatatgca agactgagca 531661 gtgcgggaac gccgatcgcc gaccatgagt ccggcgtaaa aaagaacgac aatggcagca 531721 taagaggaag cgacagaacg agtgcccatg agatcacctg ccaattcccc agacgccgtg 531781 aaagtttggc cccttctgca taaccaagac cgcatacgac aatagaagcc agcatgtacg 531841 cgtcgccaag cggggatgaa cctcccccct gaatgagggc gaaacctgct actaacaagc 531901 tgccggcagc tgagaaaatc cagaagacgg ggcgagggcg ttcacccccg cgcagtacgc 531961 cgaagactgc cgttgcgagt ggaagaagtc caatgaagac aatggcgtgt gcggatgtga 532021 catgctgaag cgctaaagct gtcagcaacg ggaaaccaat cactacgccg aacgctacca 532081 ctaacaatga aatgagatct cttttggcag gatgctgctg ccggaagatg agaaggagac 532141 ctcccgccag tacaccagct atcgcagcac ggcaaactgt gagaaataac ggatcgaagt 532201 ctgacacagc caaacgggtc gcaggcagcg agccgctgaa aatgagtacg cctataaaac 532261 catttatcca gccatttgtt gttttgttca ttataatcac tccacatatc tttcttgttc 532321 attgtctgta ttttcttaac aaaaccagca gctaaggatt acaatgacta taaactggaa 532381 ttggcctttt ataaacagcc agttttcata aaaaaatgca taccagttag gagaacaacg 532441 cgcaaatgga tatcacgcct tttttgaata gaactctgga tattccgctt tatcagcagc 532501 tttatcggta ttttaaagaa aatatgcatc ggggccgtat tcaaaaagga atgaagcttc 532561 cttcaaaaag actcctggcg aatcagcttt ccatcagcca aacgactgta gaacgtgcct 532621 atgaacagct cgctgctgaa ggttatattg tgagcaagcc aagaagcggg tggtttgctg 532681 attatcatga ttctgatttt gcttatgata gaatgccaag cacaacaccc attcaacaag 532741 aagcagaaga aaataaacaa tggattgatt ttcattatgg gaatgtagat tcttcttact 532801 tccctttttc cgcatggcga aaaagcatgg tcaatagctt agaccaatat ggacacgagc 532861 tttatcggcc gggacatgtt ttaggagagt ttgagctgag aacactcatt gcagagtacc 532921 tgtatcaatc tcggggggtt cattgcggcc ctgaacaagt gattataggt gccgggaacc 532981 ctattctgct gcaaatcttg tgccaagttt ttgagccgaa tatttctata gggtatgagg 533041 atcctggtta tccaagagca cgcaagattt ttgaagccaa ccgcatgaat attgttccta 533101 taccagtcga tgatgaggga atctgtatac agaagatcaa agaacagcag ccaaaccttg 533161 tatatgtcac accttcccat caatttacgc tgggaaccat aatgacaata aacagaagaa 533221 ttcagctgct caaatgggcg gccgaaaatc aatcctttat catagaggat gattatgacg 533281 gggaatttag gtacacagga cagccggttc cttctctgca agggcttgat cagcataacc 533341 gtgtcattta tatgggcact ttttctaagt ctcttttgcc ctcgctgcgt atcagctata 533401 tgattcttcc ttcgcctctt ttaaaaaagg gtcatgaaat cacgtcctta tataagcaga 533461 cagtgtcctg ccacagtcag ctaaccctag ctgaatttat aaaaaatgga gagtggcaaa 533521 aacacatcaa cagaatgaga aaactttacc gcaaaaaaag agccattgta ttagaggcag 533581 tgcaaaggga attaggagag catgtcagaa tccgcggaga aaactctggg cttcgtatct 533641 tacttgacgt ttatttgcca tttggtgaaa aagagttaat tgagaaggcg aaaaaacatg 533701 gagtaaaaat ttatcctgtt tctctttctt atcaacatca tcctcctaca aaaacggtct 533761 cgctcgggtt tgcaggggtt tctgaatccg acataagaga aggcataaaa aaactgaagg 533821 ctgcctggaa gatatgaggg agctttcagt ttagcaaaac ggccaagtga cgactaagtg 533881 ttgagagctg ttcaatattt tttaagtata tgatgagtgc ctgcagtcca ggccacgata 533941 cgtctgttta gcgaaaaaca gaatttttta tttgctcctc acagtgctaa aataaacaaa 534001 atagacaatt gaaaaaatag aggtgtaaga atgaagttag atgagtttac aattggccag 534061 gtcttcaaaa cgaaatcatt aaaagtatca aaagatgata ttatgcggtt tgcgggtgaa 534121 tttgaccctc agtatatgca tgtagatgaa gaaaaagcga gtaaaggcag atttaatgga 534181 attatcgctt ccggcataca aacactggcc atatctttta aactttggat tgaagaaggt 534241 ttctatggag acgatattat agccggaaca gagatgaatc atatgacatt cataaaaccc 534301 gtatatccgg atgatgaatt gtttacaatt gttgaggttc ttgataagca gccaaagaga 534361 aatgaattgg gaatactcac agtattgcta tctacttata atcaaaaaga agtaaaagtg 534421 tttgaaggtg agttatctgt attgatcaaa cgataactca gaaagcccgc ttttcgcggg 534481 ctcgattgaa gcagatgggt gaaagatgtt agcgggtttc ctttgaaaaa taagaggtta 534541 aaacatcata aacaataggc aaagaagtaa atccctcatc ttctagaaaa tgacctccgt 534601 gctgaacttc atataacgca gcatcaattt gttgtgccag atccttgctg aatgaaaaag 534661 gcacaatttg gtcgtcctta gaagcaatga cagcacggtg cttcgcggac tcgatgattt 534721 tttgatgatc aaacgatccc tgtgtaaatt catctaacat ctgtaaagtg ggcaatgatt 534781 tggcaaagcc ggaaacaagt atgattccgc caagctgttt tcgtaattga agatgttcca 534841 aaaatctcaa aatggcgggg caacctaagc tgtgcgcaac caaatacgta ttttcatgta 534901 aagtgtgctg atataaagag agtgtatcca gccaatcctc aagtcttggc tggagcggat 534961 taggcatgtt taaaatgtct gcttggaccc catctgcgag cagacgtttt ttcagccaag 535021 ggaaccaatg atttgttgag gaggctctgt agccatgaat gatatagact tgttttgtca 535081 ttatttcctc ctaagaaata ttttcattca gtataaaatt cctctcattg ggaaacaagt 535141 acgcactttt ttgtaagtag ctttacatat gaggccctcc ttgtgccatt ccccacttac 535201 acatctcatc tatgagggga tacaaagatc gccctctgtc agataacgaa tactctactt 535261 tcagtggggt gtgagaaacc tcagaccgat gaataaggcc gtcagtttgc aattccttaa 535321 gctgtgcgct taacatttta tgggtgatga agggcatagc ccttttcagc tcgccgtatc 535381 tcatcgtttt ttcacaccct aactcataga gaattctcat tttccatttg ccccctataa 535441 gagataaggt gtattcaaat ggggcttgtt tactgcggca caggctattc attgtaatca 535501 aacctccttt tttaagtatc atatcagaat aaattaggat tttcggtgtt gaagtttgag 535561 ggcgattcac gatctgaagt gaaaggggcc gcttgctcaa caggcggcac ggtacatgaa 535621 tgttctaagt caaagagggt taccttactg ttagttactt tatttaaaaa aacgcatgtt 535681 tttagctgaa aatatctatt atggtatatt taaatataaa gaaatatttg agaaatgagg 535741 aatggtatga atacacccaa aaaacataag aaatttaaag cgaaaatgat tctccaaatc 535801 atcatggtta tcattggagg aatcatagcg gcatatggac tagaaacagt gctcattcca 535861 aacagtgtat ctgatggagg ggtgacgggt cttagcatcg ttggttcaca gctattcaac 535921 ttgccgctgg ggattttgat tgctgtgatc aacattccat ttgtctggtt aggatataag 535981 caaattggga aaagctttgc attattatca attatcggaa tcgtatcgct tgccgcgggg 536041 acaagctttt tccaccacac acccgctatc atagaaggag ataccctgtt aattaccgtt 536101 gtcggcggga ttatccttgg attcggaatg gggctggcgc tgcgtaatgg cggcgcatta 536161 gatggaattg acatgcttgc tgtgctgcta tcccgaaaac tgccattcgg aacgagcgat 536221 ctcattctat tcttaaacct atttgtgttt atttttgttt ccacagtatt tggcttacaa 536281 ggggcattgc tttcagtcat tgcttactac attgcatcca aagtgattca tgttgtggag 536341 gaaggcttaa gcggctctaa aacctttcaa attattacaa cccaacctga attaatggta 536401 gagacaatac gtgatcaatt aggccgaagc gccacatata aagaagctta cgggggtttt 536461 tcccacgaga aatttaaaga aatcacatgt gtcatcaacc gtttagaaga aaccaaacta 536521 aaggaaatta ttaatgatat tgataaaact gcctttgtta ccgtgtatga tgtagctgaa 536581 gtgaagggca gcaattttag aaatcttaat catcactaaa aaatagaatg acctttttaa 536641 ccgtaactga catgccgcgg gtaatttaat caaaaacact tttttgaggc ttgtgggtga 536701 ataaccggtg aaggtctgaa tcacagaaat accaagggcg tcaaaaccct tggtattttt 536761 tctggttatt agattttatc ttcagcttta cgtgctgctt cgagcttatc aatcctgtct 536821 ttatattttt ctccccagtc cttcatgtgc aggataacag gttctaatgt tcttccaaac 536881 tcagttaaag agtattcgac ttttggaggg acctgtttat aaacctcgcg gtgaatcacg 536941 ccatcccgtt ccaattctct taattgtagc gtgagcatac gctgggtaat ttttgggtat 537001 agttttcgaa actcattaaa cctcttttta ccgtcaatga gatgataaag aagaatgcct 537061 ttccacttac ctccgatgat atctaatgtt gtctccaccg gacatccttc aaagtcatca 537121 gaagaataat caatgccgag tttacgattt ctcaagctgt tcactcctaa tagtatactt 537181 tttgatacta tatacattca atgtgcgtac tttttatatt ttaatataca tcatataatg 537241 atgtcacatc taaggaatga aaggaatgga tcatatgaaa acactcgtac tcgttgtaca 537301 tccgaatata gaatcctctc gtatcaataa aaagtggaaa gaagccgttt taagtgaacc 537361 agatgtaact gtccatgatc tttatgaaaa atatcgcgat caaccaattg atgtggaatt 537421 tgaacaacag cagctcctgg cccatgaccg tatcgttttt cagtttccat tatactggta 537481 cagcagccca ccgcttttaa aacagtggtt tgatgaagtg tttacgtttg gctgggctca 537541 tggtcccggc ggaaataaat tgaaggggaa agagtgggta actgccatgt ccatcggttc 537601 acctgaacac tcttatcaag ccggcggata taacttgttt tcgataagcg agctgacaaa 537661 accgttccaa gcatctgccc atttagtagg catgacctat ctgccttcct ttgccgaata 537721 tcgcgccaat acaatcagtg accaagaaat tgccgaaagt gcgaatcggt atgtaaagca 537781 tattacaaat atagaattaa acccgaaggt tcgcctgcaa aggtatttga aacagctgga 537841 gagtgtcgat ttaacataaa gattgatttt tgaaaatcct gtactcacca agcaggattt 537901 tttcttgttc agcagaggga ttttaacata tagcaaaaaa agaagaagcc accaaaaata 537961 agctatttgc ttggtcctga ctgcttattt ttggtgaaat acttatttct ctgtgatgaa 538021 ataaagcaaa gcgatgaccg gaaaagcgat tccaatccat aatgctgtac tccatccgcc 538081 tgaggcatat gcccatcctc caattgatga ccctatcgca ccgcctagaa agaagatcgc 538141 catgaataat ccgtttaatc gactgcgaat ttcaggcgcc aacgaaaaaa tagcacgttg 538201 actgagcaca aggtttgcag atacacccat atctaacaga atagcagcgg ccactagaac 538261 tgttataccg acgggggagc tgctctgaat catgagcggc agtaataaag agacaacgac 538321 aacaccgaga gcgattccag tggcaagcct ggttaagcct cgatcagcca ggcggccgcc 538381 tattggtgca gtgactgcac ccgcaatgcc caccaatgcg tagagtgcta ttgccttctg 538441 agaaaaatga aaatcaggac cggacaataa taaaggaaca gttgtccaga acaagctgaa 538501 agctccaaat acaaacgcat gatagatggc acggcggcgt aagactggag tcgtgcgcag 538561 cagcttccac attgaaccga gtaaggcagt atagtttgta tttgctgttg gttttctggc 538621 aggaagcact tttgataata cgatggccag gataacactt accacggcgg acaaagcgaa 538681 tattgcattc cacccccaga tatcagcgac tagactagat atcggacggg aaagcataat 538741 accgagtaat aagccgctca tgacattgcc aacaacccgg ccgcgtgcag cgtctgatgc 538801 aaggtatgat gcaaatggaa caagcacttg ggctgcgatt gatcccaatc cgacgaaaaa 538861 cgcagctgct aaaaacagtg ttccatgctt cacaaatgct gttagtgtca aagccgctgc 538921 gcttagaagg agcgatacaa caataagttt tttgttttcg ataatatctc ctaaagggac 538981 aaggaatagt aagccggcaa cgtatccgat ttgggtgagt gtgacaatca atccagcacc 539041 gcttggagaa agtccaattg ccttactaat taatccgacc aagggttgtg catagtaaag 539101 attagcaaca atgataccgc atgcagttgc gagaagaagg gttaaactgg gtgaaatcct 539161 ctgacctgct tgtttgtttc cattagccat atgaatgaac tcctttttaa gtggtttttt 539221 gagtgtaatc atgacttctc acaagtgatt ttataaactg aacgttcagt ttcgtcgatt 539281 aataaaaata atatactaaa cgttcagttt tgtaaatgga tttctgtttt ctttttttat 539341 tcaatttaag tatactgaac gtatagttta tattgcggga aggaatgatt tatgtgcaga 539401 gtaaacgagg gcggccgcgt gatgaaggaa cgcataaggc gattctctct gcagcctatg 539461 acctattgct ggaaaaaggc ttcgatgcgg tgacagtcga taaaattgcc gagcgtgcga 539521 aagtgagtaa agcaacgatt tataaatggt ggtctaacaa ggctgccgtt atcatggaca 539581 gctttctttc gaccgcgacg gacaggctgc ctgtgcctga tacagggtcg tcagtacaag 539641 atatagtaac ccacgccacg aatttagcta ggtttttgac aagccgggaa ggaaccgtta 539701 ttaaggaatt aataggtgca gggcagttgg atgaaaaatt ggcagaagaa tatcgcacgc 539761 gatttttcca gcctcgccgc ctccaagcga aaggccttct agaaaaggga attcagaaag 539821 gtgaattgag agagaatctt gatattgaag taagcataga tctcatttac ggaccaattt 539881 tctatcgtct gcttataaca ggggatgagg tgaatgattc ctatgtgcgt gatttggtga 539941 tgaatgcgtt taagggagtt caagctacct ctgctacaga gagtatgtag ctgataagaa 540001 ctgcaaaagc tgcggattat atgacaaatt ggttccatcg tacagtgaaa tataagattt 540061 ttgttgctga gcggaatcat cgagggaaaa gttctcttat cggatgtcga aaaagaagtc 540121 attcaatcgt gaatacataa catcatatta ttacattcct tttcatcgat tggaacaagg 540181 gttctatact tcaatggaat accgcaaagt tggagtattt aaacaacagg ggaaaatcga 540241 tggccattat gtaggtgtca tggcaatgga aaaaatactt gcaatgtaaa caggcctcta 540301 aagagacctg ttttttaata tccagatgat tgtctagttt cagcttgggc tctatgacca 540361 ctcccataac tgaaatagtc taatatttat accagaaggg attgtttata taaataaaag 540421 tttatataat gacgggggcg ctaaggaaac gcggggagcg actcaggttt tcgtttcaaa 540481 gttttgatcc ttaagatata cggagcgcta catatggaaa cgtaaagggg aatgtataat 540541 catttggcgt gtatataacg atttgcttat atattgattt gggaaggagg agctcatatg 540601 acgattgatg ttgcggcgat gactcgttgt ttgaaaacac ttagtgatca aactaggctt 540661 atcatgatga gattatttct tgaacaagaa tattgtgtct gtcaattggt tgatatgttc 540721 gaaatgagcc agcccgccat aagccagcat ttgcggaaat taaaaaacgc aggttttgtg 540781 aatgaggaca gaagaggcca atggcgttat tattcaataa atggttcctg tcctgagttt 540841 gatacattgc aattgatctt acatcaaatt gatcaagagg atgaattgtt aaaccatatc 540901 aaacaaaaga aaactcaagc gtgttgccag taaggaggca ttagattgac atcaatgatt 540961 ttggcagtat tcatcttttt attaactcta gtattggtca tatggcagcc gaaaaattta 541021 tctatagggt ggtcagcctg tggaggcgca gttttagctc taatagcagg tgttgtcaat 541081 tttcatgatg tgttaactgt gacagggatt gtttggaatg cgaccttggc ttttgtggcc 541141 atcatactga tatcgttaat tcttgataat atcggtttct ttgaatgggc agcgcttcat 541201 atggctaagg ctgcaaaagg atacggtgtg cggatgttcg tttatgtatc tctattagga 541261 gctatcgtcg ccgcgttatt tgcaaatgac ggtgcagctc ttatattgac accaatcgta 541321 ttagcgatgg tcagagcatt acattttaat gaaaaattag tttttccttt tatcattgcc 541381 agcggattta ttgcggatac cacttcgctt ccttttgtag taagcaattt ggtcaacatt 541441 gtttcagcgg actattttca tattacgttt attgattatg catccagaat ggttgtcccg 541501 tacctgtttt cgctgctggc gagcatcatt gtactttacc ttttctttag aaaaagcata 541561 ccaaaacgct atgatctgac tgaggttaaa aaacctgttg aagcaattaa agatcaaaac 541621 atgttcagac tgtcatggta tatcttaggg ctgctgttaa ttggatattt tgcaagtgaa 541681 tttttttcta tccctgtatc agtggtagcg ggcagcattg caatcatttt cttaatcgct 541741 gcgcaaaaga gtccggccgt ccatacaaag aaagtggtga aagaggcgcc atgggctatc 541801 gtattctttt caattggcat gtacgttgtt gtgtatggtg tccgaaatgc cggattaacg 541861 gatgtccttt cagatgtgat tcaagccgca gctgatcaag gattgtttgc tgggacaatt 541921 ggaatgggct ttattgcggc gattctttct tccattatga ataacttgcc gactgttatg 541981 attgacgcat tggccattgc cggtacagat acacatggga tgatgagaga agcgcttatt 542041 tatgcaaatg tgatcggttc agatttaggg cctaaaataa caccgattgg ttccttagcg 542101 acattattat ggcttcatgt tctttcgcac aaaggtatga agatttcctg gggcacgtat 542161 tttaaaacag gaattatcct cacgataccc actttattga tcacacttgt cggcctgtat 542221 atttggctgc tgataatcca ttcttgtttc taaaaggaca aggtcactat atcaaggaaa 542281 acaatgcact ggtaactctt gccgcagcca aatggctgaa gggtggggga gaaaatacct 542341 tggggctaag tggaatgtgt acagcgcagg aatcgaagct caaggatgac atcgagtgct 542401 gtcaaagcaa tgaaagaagc agggattgat atttcaaatc aaacatcgga gaaatttgat 542461 gatccggcaa aagcacacgg aacagaagaa gtgtttccaa agggtccgtg atgaaattgg 542521 tgaccgttta aaacagtttg ctgtaactgg ggaataaaga atcgatatat tcagcgtttt 542581 cttgggttat ataatacaat gtgttgttca acaggtgtct gcgagctgag tgcagacacc 542641 tgtttttgtt tttatttgtc tgagattcgt aacagggaag ttatttagct ggtgacagag 542701 gaaaattgat ttgtgaacag aatcatgaag gagacggtgt tttaaaggag ttgtctgttt 542761 tgcaggaatt aacaaaaaaa aaatacagta gcttaaaaac aatgtttgat gacaaatatt 542821 gtcccacatt tgtctattca atattagacc aaaccattcc gggagctgtt tatgcagatg 542881 atcaaacctt tcctaaatcg ttttttatag gaactgaatc aggcatttat tttattgcgg 542941 gagaccaagg gaatcgggat tttcatgatt tcattgcagg atattatgaa gaacaagtga 543001 aatcatcaaa acgatttacc ttgttttctt ccagtgatac atgggatagc gtactgaaac 543061 ccatactgaa agatgactta aaccaaatga gaagagctgc attttcttat caaccaaaat 543121 ctttcaaaaa gactttgcaa ctgccaaagg ggcttgtatt gaaaagaatt gacgaagaca 543181 tcatttcaca tagcacagcg tttaacagcg cgtattatga ggagtattgg aattctgtct 543241 cacagtttgc ttcaaaaggt tttggatttg ccgtattaca tggcaatcac gtagtaagtg 543301 agtgtacctc tatattttta gggcataatc gagcggaaat ggatatctat acacttgaag 543361 aatatagagg actggggtta gcttattgcg tagcaaatag gtttatagcg ttttgtatgg 543421 aaaatgggat tgttcctagc tgggattgtg atatttgcaa caattcgtcc attgcattag 543481 cagctaaact agggtttaag acggtaacgg aatacactat ttactactct ggctaacctt 543541 aatgaaagaa ccttaaaagg agataccaac cgatgttggt atcttttttg ttttagagtt 543601 tttttaccct tttagcagaa aaatgggtga tgaaaatctt attcatttta tttactttta 543661 ggtaggtaaa acataccccg ccaactgtaa ccactccgcc tagcagagag agcagtgtgg 543721 gtatctcgcc gatccagagc caagatatga tcaaggctaa agccggtgta acataaagtg 543781 aaagggttgc ttctgaagca ccgacgaatg aagtgacata tgctagtgcg aagtaaggaa 543841 taaccgtcgg caataatcct aagtaaacga tagacaaagt tgcgcttatt gaagcgttca 543901 tcatctcttc gcctaagcct ggcagaaaca caagcatagg tattgttccg ccccaaatgg 543961 tgaatgtaac gaatggaata aaaccatatt tttttatata gcgggcttga aaaacgaaat 544021 aaatactctc cgaaaatgct gccagcagga tgaccaagat accgctcatt gaatatgtaa 544081 agtctcccgc cccaaatgca atcaataata cacccaataa actgatcata gagccaagcc 544141 atttcgtaaa tccaaaatgc tctttataaa acaggcggga tagcatggct gagaagatcg 544201 gtgccgtagt aacgagtaag cttgcaactc cggcactaac tgttttttca ccgatgttca 544261 gcaaaatgtg atagaatgca aatcctaaaa accctaaaag aaaaatggca ggaatgtctt 544321 tcaagtcggg taggcgcatc tgagtcaaaa cagcaaaaag caataatgcc atagagccga 544381 ttaacaaacg aaataaagca aggtgttctg gcgtgtaccc ttcaagtcct gcgcgaattc 544441 ccggaaaagc agatgcccat aaaccaatca tgagactatg agatatcatt atttgaactg 544501 ttttctttcg cattcctctc actcctcttt acaaaaacca accagttatt taatgtgttt 544561 ctatactaat aaagatttga tgatatggct tcaaccagtt caatagattt tgacccaacc 544621 aatttatttt aaggagaccg attctatgag ctttccagaa gaaaaaaaga tgaaaaagct 544681 ccctaagtac agacaaatcg ttcattttat taaagagaaa ataggaaatg gagagtggcc 544741 gattggaagc aagattccaa gccagcgcac gcttgcaaaa gattttcagg taaatcggag 544801 cacagtgatt acagcgttag aggaattgat ggccgatggg ctaatagaag gcacaatggg 544861 gaaaggcaca gttgttatca acaacacatg gacactgatg gctaagaatt ctgctcccga 544921 ttgggatcaa tatgtcacct ctggcattca gatgccaagc cgaaaaatcg ttcaagagat 544981 aaatcaatca gaatcaaata cagaccttat acagctcagt aaaggtgaac tttcagctga 545041 gatttttcct ttggctgtta tgaaagagat gatggggaag gtatctcaac acatggaggc 545101 attcggatat gaagaaccaa aaggttactt acctttgagg gaggcattaa gcaactattt 545161 aaaaaccatt ggaatcaacg tctcatcttc ttccattctg attgtctcag gagcgttgca 545221 agccttgcag ctgatatcaa tggggctgtt acaaagagga tcaaccgttt atcttgatca 545281 gccctcctac ctttattcat tacacgtatt tcaatcagct ggtatgaagc tgactggact 545341 tcctatggat aatgaaggac ttttgcctga aaatgttcat ttaacaagag gagagcgggg 545401 aagggctatc ttatatacaa atccatgttt tcacaatccg actggtattc ttatgtctaa 545461 aaagcgacgg gaagaaatcc tagcagtaag tgagaataca cagcttccta ttattgaaga 545521 tgacatttat cgtgagttat ggatcgatga aattccgcca tatcctatta aaacaattga 545581 taaaaatgga cacgtactgt acataggaag tttatcgaaa acattaagcc caggtttgag 545641 gattggatgg atcgtcggac cggaaccggt gattgaacgt ttatctgaca ttaaaatgca 545701 aacagattac ggatccagtt cgctatccca gagagtagcg gcagagtggt ttacttccgg 545761 ccactaccag cagcatgtag aaaaggttag gcagcaatta aaggtgagaa gagaattggc 545821 cttgagtgct ttagaaactc atttgaaaga agtggcgaca tggaatatcc caaaaggagg 545881 gttttttgtc tggataaaaa tattgccttc catatcaatg aaattacttt atactaaagc 545941 cttatcaaaa gggattctga tcaatctcgg cagtatctat gctcaggaaa aagggaatta 546001 tattcgctta tcatatgctt atgcatctct tgaagacctt caaaagggga tttatgagtt 546061 gggtttaatg attaaagaat tggcaagcag gtaactttta tatccttaaa tggatgtttc 546121 actaaaaaag agatcaagcc taatgatcgc ttgatctgat aataacaagg gttactagaa 546181 tagaccaaat catggttcgg tcttaaaata atcatgtctc tgaacgaaaa gtctttccga 546241 cttctcttcc taaaccaaag tagtgtctga aattatagat aagcgggctc catttggaag 546301 ggttgatatg gttttcgtcc agaatgatac tttcctcggc atgaaaatgt agtgcctgcg 546361 tctctacaat tgcgaatgac gattcatatt ctggaagccg aatgtgtttc acttcggctt 546421 cgatttggat agggcattct ttaattcgtg ttggtgatac tgtttttgat tgtaaaggcg 546481 ttaaccctgc tgcctcgtat ttttcttttt tatatgtaaa tccgatctgc ttctttaaag 546541 gcggtatact cttttttccg ctataagatg aaattctttc aacgttttcc cataaatccg 546601 ggccaggcaa gtttatgaca cactctttgt gtctttccaa attgtcgatg gcttttcctc 546661 ccagtcctac tccaaggatt atataatgtc caagagccca agaagaagac ataggactaa 546721 tattagtggt tccatcctca ttcaatgtgg ttagaagaaa tgtcgaggta ccataataca 546781 tgatcttggg tttgatttcc ttaaatcgac gagtgtcttg ttttttgatg tccaacgttt 546841 tttcctcctt gtcacgctta catttatatt gtaaaggatt aacatttcaa ctatcatcga 546901 aatatgaatg taaggaggaa aatcatgaat cctaatattg caaaaatctc ttcgttgcta 546961 tcagatccct cgcgttcttc cattcttctc agtctgatgg atggaaggat acaccctgcg 547021 ggagagcttg catatctcgc taacattaaa cctcaaactg caagttttca cctgaataaa 547081 ttgcttgaag caaagctgat tagcgtagag aagcatggga gacatcggta ttacagattg 547141 gctgactcag atgctgcaaa tgtgatcgaa caattgcttc atattgcgcc taaagcaaaa 547201 gtcaaatctt taaaagagtc aaaagagaaa aaggacttgc atttcgcccg gacctgttat 547261 gatcatttgg caggttatgt gggcgtgcaa atggcacatt cactagttga gcaggggatg 547321 ttaaaaaaag ttgatttaaa ctttgaggtg acttcagagg gtgctttatt cttttcgaag 547381 ttaggcatca atgaagagca acaacggaat aagaggagag cctttgcccg ctgctgtttg 547441 gattggagtg aacggcagca tcatattgca ggagcattag gaaacgccct attggtgcgc 547501 atgttagaag aagaatggat cgttcgtatg cctaaaacga gagcgattag gattacacaa 547561 agcgggaaaa tcgcgtttga aaagcaccta aacgtgaaga tttaggattt tgaagcggaa 547621 acatcagatg atgaggcacg atatctagga ggagtaagat ttgttctaat cttactcctt 547681 cttcttattt tgaagcagct cgattcccca ttgcaataga gatgcggttc caactgttta 547741 tttgattaat gatcagaaca aggtcaacat attgttcctc atcataatgt tcccgcaccc 547801 gatgatatag ctcatcagga acccttttag atggaatgag cgtgatgtgt tcagatagtt 547861 cgagagccgc tttctcttca ggtgagtaaa aatcacattc attccaagca tgtaaacagt 547921 aaattcgctg ttcagtttct cccattttgc gggcatcgga cgtatgcata tctatgcaga 547981 aggcacagcc gttcatttga gagactctga ttttgattag ttctctcgtc gttcggttaa 548041 ttgaggattg tttcgtgtat ttctccatat ccatcatgat tttcatacct tcaggtgcaa 548101 tctcatagta ggacactctt tgactcataa agcaagactc ctttccatag aatacctaga 548161 ttgtatcccg gtattgatca ttttaccaat gtgcggtttg aatgacagct gtttcagcgt 548221 cttttggaaa gaagcttctt tgaataaaaa taagggtagc cagcaatgat gagtggagct 548281 gctaatgcaa gcagtatcca tgagcctgat tggctgtctc tagtgactct aatgaatata 548341 taagtaccga tcagaaaata taataaagca cctagaaacc aatacatgtt cattcctctt 548401 tttccttgct ttttggttgc gcatttttgt ctgtcatatg gcttaatcga tcagggttct 548461 gattttttaa taccttttcg gtccggattc cttttctctt taatgataaa attgtgagat 548521 caatcgattt caatgatgat cattccttca atgaatagta agttccttat gattttaaag 548581 gtaaatttga aaagataaaa cgtacataga ggcagaacgt tcatgtacgt ttgggcaatg 548641 atcacttgtt ggaaactcta atgtttccct gcacctgata ttgttgtgtt ccttctcttc 548701 ctataaaatg attggataca tgtatgtttg cacgttgaaa tatgggttcg attttcatga 548761 atctctattc ggtgaaacag gtaaaggaag tggataaggt ttgcttataa ggaatccttt 548821 taaagataaa tattactcac atgataggcg ggcattaaac atgcttgcac tcagagtgcc 548881 gggcctggct tttattctca tgatctatat agcctctatc gtgctgcaat ttgtttctgg 548941 gggctggtcc attttattgc tttatgcgtt taccatatta atcgccattt ttgctttgct 549001 tcattggcac tcatatcgct gggttaagaa aagagtgatt ctgtatttcg cggtacaagg 549061 tttgatcacc tttgcacttg ctaatctcat gactggcttc tttatacttg tgattatcgg 549121 cctttatgca tttttaattg gacaaattat aggaatggca gacagaagaa ggacttttct 549181 cattctttat ctattgctgc tgctggtcat aaattcggcg tatcaccttc ataaaggtga 549241 agttttgcat tttattgtta ttgctgcgcc gatcatgatt gtcatcatca cttatgccgc 549301 aacatttttt gcccaagtcg atgaaaaaat aaaagctcaa ttgactcttg aaaggctgga 549361 gctggctcat cagcaggtag aacagctgac gctgcagaac gaaagacagc ggatggcccg 549421 agacttacac gatacgcttg ctcaaggtct tgtcagttta aatatgcagc tggatgcgat 549481 tcatgttcat ctcgccaaag gcaacacaga gagagcgaag gaaatcatac aacaatcgat 549541 gaaaagagtg aaaagcacaa tagctgatgc acgttcagct attgacgatc tccgcagcaa 549601 atcagaagaa atcggtgttt taaaagaaag aattacctcg ctaatggatc attttataga 549661 gtcgacaggc atggcttgtt tattagatta cagattgcat caggtgctgg atgtgcgtac 549721 agctgaaaac tgttattaca tcattggaga atgcatgacg aatgcggcaa agcatgctga 549781 ggcgaaaaca atctggatat ccatttggga tgatgaaaag ggaaggctcc atttaacagt 549841 taaggataac ggcaagggat ttgatgttga aaaaggaaag aaaaagagag gacattatgg 549901 gcttcttggc atacaagaac gcgtcagggc aataaatggc caattcaata tcaagagtac 549961 aaaattgaaa ggaacacaaa ttgagatcac tgtaccaatt cagggagaga tgcaagatga 550021 ataaggtttt aatcgttgat gaccatcttg tcgtgaggga aggtctgaag cttttaattg 550081 aaacgaatga tcaatacacc attataggag aggcggaaaa tggaaaagta gcagtccgtc 550141 ttgcagatga attagaaccg gatatcattc tgatggattt gtatatgccg gagatgagcg 550201 ggttagaggc cattaaacaa ataaaagaaa aacacgatac ccccatcatt attttgacta 550261 catataatga agatcactta atgatcgaag ggattgaatt aggagcgaaa ggatatctgt 550321 taaaagatac gagttcagaa accctttttc acacaatgga tgcagccatc agaggaaatg 550381 tgctattgca gcctgatatc cttaaacgtc tgcaagaaat ccaatttgag cggatgaaaa 550441 agcagcgcaa tgagacgcag ctgacagaaa aggaagtcat tgttctaaaa gcaattgcta 550501 aaggtcttaa aagcaaagcg attgcctttg atttgggcgt ctctgagcga acagtaaagt 550561 ccagattaac gtccatttac aataaattag gcgcgaattc aagaactgag gcagtaacga 550621 ttgccatgca aaaaggtatt ctgacaatag acaactaaac tgcatatttg aaaattgccc 550681 aaacgtacat gcccgaatgt acgttttttt catttcattg tcaactacaa tgagaaagaa 550741 tgtgatcaag caatgtgttg aaaggagatt atcatgtcaa aaatgttata tacattagga 550801 ggatgggttg ctcgcaatcg cataaaagca atatgtgcgt ggatcgttgt gttagttgct 550861 gcgataggcc ttgcagtgac cttgaaacca agtttttctg aggatatgtc catacctgac 550921 acaccttcgg aaaaagcgat ggatgtgatt caaaaagaat ttcctcatgg tcctgataaa 550981 gggagcatac gggttatttt cggtgctggt gatggggaga aacttactgg gaagccagca 551041 aaaaaagcaa tagaagatac gttcaaagaa atcagtaaag atgattctgt tgactcgatt 551101 gcaagtcctt ttgtgacagg gacaatcgcg aaagatggca cagttgccta tgctgatatc 551161 cagtataaat catcagcaga tgatataaag gattactcta tcaaacactt aaaagacagt 551221 ttgaaaatgg ctgatgatga aggattgcaa actgagctaa gcggagatgt accgggagcg 551281 gagatggaga taggcggtgt ctctgaaatt gtcggcatta tcttggcttt tgtcgtttta 551341 gccattacat tcggttcttt attaatagca ggtttgccga ttttaactgc actgattggt 551401 ttaggtgtaa gtattggact ggttttgatt gggacacaag tatttgatat tgcttctgtc 551461 agtctttcat tagccggaat gattggcctt gctgttggta ttgattatgc tttatttatt 551521 tttacgaaac accgccagtt tttaggcgaa ggcatacaaa agaatgaatc aattgcgaga 551581 gccgtgggaa cagcgggaag tgcagtggtt tttgccggac ttactgttat cgttgcactt 551641 tgcggattaa ctgtcgttaa cattcctttt atgtctgcga tggggctgac agcagggctt 551701 agtgtactga tggctgtttt ggcttccatc acacttgtgc ctgcggtctt atcgattgca 551761 gggaagcgga tgattccgaa atcaaacaag aaaatagaaa aacaaagcac tgaaacaaat 551821 gtctggggac gctttgtcac caaaaatcct atcatgctaa gtgtatgcag cattctgatt 551881 ttgatcgtca ttagtatccc atctatgcat ttggaactgg gcttgcctga tgctgggatg 551941 aaagctaagg ataatccgga tcgccgggca tatgacttgc ttgccgaagg ctttggagaa 552001 ggatttaatg gccaattaac aatcgtagcg gatgccacaa atgctacaga aaataaggcg 552061 gaggctttcg cagatgcagt gaaagaaata aagggcttag accatgtagc aagtgtcact 552121 cctgcaatgc ctaataaaga agggaacttt gccatcatta cggtcgttcc tgaaacaggt 552181 ccaaatgatg tcacaacgaa agatttggta catgatgtac gcagtttatc agataaaaac 552241 ggagtagatt tgcttgttac tggatcaact gcagtgaata ttgacatttc agatcgcctg 552301 aatgatgcga taccggtgtt tgctgtactt attgttggct ttgcgtttgt attgctgacc 552361 atcgttttcc gttcgctgct tgtgccgctt gttgctgttg caggtttcat gttgacgatg 552421 acagccactc ttggaatctg tgtatttgtc ttgcaagacg ggaatctcat cgactttttc 552481 aaaatacctg aaaaagggcc gatactcgcg ttcctgccga ttttatcgat tgggattctg 552541 ttcgggttag ccatggatta tcaagtattc cttgtcagca gaatgcgtga agaatatgta 552601 aaaacaaaca atccagtaca agccattcag gctggattaa aacacagtgg tcctgttgtt 552661 acagcagccg gcttgatcat gatcttcgtt tttgcaggat ttatctttgc aggcgaagct 552721 tctattaaag ccaatgggct ggctctttcc tttggtgtac tctttgatgc ctttattgta 552781 agaatgacac tgattccaag tgtcatgaag ctgatgggga atgcagcctg gtatttgccg 552841 aaatggttag acaagattat tccgaatgtg gatatagaag ggcatcaact gacaaaggaa 552901 atacagccgg aaatagatca tgaacaaaag aaacaaatca gtgtgtaata gaaaaagcag 552961 atcttttatg atctgctctt ttgcttatgg tagtatttag aagatgaagt cggcagttaa 553021 aaggagacgc ttatggcgcc atcactcatt ttcgatatgg atggaacttt gtttcatatt 553081 ggcagaagct gcatcatact agcaggcatc ccaggagaag tgacatgatt ttttgacttt 553141 gcattcacta cttgatgcca aggatcttga gaatccttct tgaaaataaa ggattttaca 553201 actgatcata taagaaacct aaagaaacaa gcacacaaaa ccagctgcgg gttttgtcca 553261 agaaaaatag agtccataag agggactcta ttttttgaag tgcccggcta gaagcatatt 553321 gcaggacttt atgaatgcaa atcactatct tataagccct taccgtgaaa tgcctgtttc 553381 tgcattgaaa aaacgcatta cacgttcatt tacgtaagtg ggttgttcca tcgataaaac 553441 atgtccggca tttttaatga cttccgcctc aatatctgga acgaatgaag aggctcggtg 553501 cagggctgag tggggatcat agatgacttc atgttcacca agtaataata ggataggaac 553561 tcttgctgaa cgtaattcct catcggtaaa aacatacgga aatccgtcgg cattaggatt 553621 tggatttctt gatccatcct gccacattac ccctgcctta aactgcttca caaaaatcgg 553681 gtgcagcaca ttctgatcat tcatcatcca atttaagaat gtttcaactc catttgacgc 553741 tgtaaggcca agagcgtatt tgtagaaatc gtgatgaaat ggcaaaaacg tttctgccgg 553801 actcagtata gctgcgcttt ttactctctc aggcatacgt aaaaggaaat tcatcgtatg 553861 gagaccgcca agcgaaagtc cgatcatgtg ggacttttcg atccccagat tgtcaaacac 553921 atcaagaagc caattggcgt aatccgttct tgtaccgctt acattctcag gaatactctt 553981 gtttttatca cctatgatat caactgcata agttctgtat ttactgctcc aatcggcgat 554041 gttgggatac cacatcgtcg agctgaataa tgctccgtgg agtaatacaa gcggcggggc 554101 atcctctggg ccgcttgcaa tcacatgtgt ttgaccaaaa cgagtagata tatagaatga 554161 tttacaacgg accggccaaa gactaaggct ttcattataa gtttgataat agcggatacc 554221 gttgtcactt aattcgggaa tactagatga atggtttgac atacaaatgc ccctcccaat 554281 tttgtttaaa tgaatgtgcc gtttcgtgat ggggaatctg attttgatat aacagacttt 554341 atttacaata taatacagtt gttattagac gtcaaatcca agatgaaaag gaaaaaaacg 554401 attgaaacag attattgaaa atcaatataa cagaatatta acctcctttg tggagccgct 554461 tcattaaaac cgcaatccaa atgcatgaat cacaaaaatc acaacaggag ggatcaggag 554521 ggaaggcagc agattcagtg ttttgaactt cttgattcca agaatgctta gacctgaact 554581 gaggatgagt atgcctccca caattgtgat ttcattaata aggtctgtat tgattgcgct 554641 ctccattact tgtgcaaata aatagatgga gccctgccag gaaaataata caagtgcggc 554701 agccgctatt ccaaaaccaa aagttgaagc gagcacaatg gaggtgatcc catctaacat 554761 cccgtttgtc agaaggtatg tataatctcc atgcaaagcg gcttcaacag ggcctaatat 554821 tgacagcgaa cctatacaaa ataataagac cgcagttgat aagccctctg ctaaattgct 554881 tttagaaaat ttgttcacca gcttgttgaa tcgtaattct aaattgatga tctggcctag 554941 caaacctcca atggctaaac tcacgatgaa tagaatgggg tatttactat caggcaaatg 555001 ctgtgtaatg gcgttgatcc ccagtgcgac cgcagcgaat cccattgcct gcatcaaaat 555061 atcctggtat tcatctttaa tgcctttttt gaatatcccc ccgattatgc ttcctgcaat 555121 gatcatcact gtgttaaaaa tcgttccaaa cataagcttt ctcctccaaa aatcattcct 555181 gcataaaaaa taaaccctct agttagtaga gagtcaaggg agatcaaaac atattcatga 555241 gattatttga tgggcagcag gatttcagtc acgtaattat ctaggttatt cgtaatgcca 555301 taatcaatga gtgtgatttc gattgagtcc cctgctacct cataatgatg ttctttcata 555361 tatgccagta attttttgta gtatggttcg gcttctggat gtgacccttt aaacctaatt 555421 tgcagatatt ctcttgaagg aaagatgatt tctgaagaag ttttttcatt ttcatcttca 555481 agaatcataa atatactgga atatttgtca aactgttttg ctttcacatt tgctgcagaa 555541 atggataaac caatcttgcc tatgaatata tcttcgttta cattcaggtg ggttctcaat 555601 tcagctaacg aatgttcgat atcatggccg agaacatatt catgctgcaa ataggccaca 555661 cgcattgcgg gaagtttgat ttttgaaatt tgatgtaacg gcatgttaac ggcatcttct 555721 atatgtgtga tgcgtcggga gatctttcgt tcaatgcgtt ccaattcttt cttcttgcga 555781 tcaatttcaa cctgctggct ttttagtaaa tgaagaagag tgtttgtatt ttgagagtta 555841 taaaaatcaa gaagcttatt gattggcagg cctagggccc tcaaatactt gatggtatcc 555901 agccgctcaa actgttgggt agaataatat ctatagttcg tttgctcatc tttatattcc 555961 ggtttcaaaa ggccgatttc atcataatac cgaagagcag agattttcac attgaataac 556021 tttgacactt ctccaatcga aaaaaattcc ttcattctaa caacctttct gtcctatgat 556081 tgatatacac acattatata gtacggcgag tactaaaggt aaagtttgca gcataaagaa 556141 aaaactcctt ctaaaaagga gcttttcatt cttcgaaata aggatttaca tggatgagca 556201 cttcttctac atctgaaaac tgtcttttga tttcatttcg aatttcgcgg gcaatgtcgt 556261 gtccctgctt aattgtcaaa tcatgatcca aagataaacg gacatcaagc aatttatagt 556321 ggccatgttc tcgcgcgcgg attctatcaa ttcgttttac ctgatcacat tgaaaaataa 556381 cagctttata ttcctctatc agctcgggat caacactctt ttccatgagc acatcaacag 556441 acggcctgat taattccatt gaaatcttaa aaatgaggta agcaacgatt gcactggcaa 556501 tggcatcggc gtacaacaga taggaccatc cacggctgtt tccgatgata gccaacagga 556561 cgccgataaa agcggcaaga gaggcaacga tatcgccttt atgatcgtac gcaatcgcta 556621 taatcgcttt gctgttccat tttttccctt gctttataga ataacgatat aagatttcct 556681 tagccacgta cgaaatcaga gccgcaaaca atgcgctgta ttggggaacg cttggccctt 556741 taacaaagga cagaatcgct tctatgagga tataaacgga tacgatcact aagataattc 556801 ctacaatcgc ctcactaatg acttcagctt ttccgtgacc aaaaggatgg tcttgatcgg 556861 gcggtttatt ggaaattccg atcactgcca agactgcaat cgaagcaacg acatctgccg 556921 cggaatgtat tccgtctgca aacacggctt cactatcgcc taccagccca aaaaagacct 556981 ttcctgccat taagatcaga ttggcgatca atgcaatcaa agcaactttt ctgcttattt 557041 gttctctttc acttgccatt ttttcctcct ataaaactgc acaaaaaaat aggagtgctc 557101 tatatacgct ctccgtatcc tttcctgtgt aatcactttg tttatcatac caattcaatt 557161 tcgagtgggt ctatagcaac gttgtttcct gtttactaat aaataaggtg acagaaaaaa 557221 agttggagct atgctaaaaa ggtcatacag caaacaaatg agttcttatg taacaacagt 557281 gatgattcgc tattaaaatg ctgccgtcag tgaaaaattt ccacctaatt ttcaaaaacc 557341 tattgacatg agaagatctg tattttacta ttatctcata ttcaagatat tttaatttga 557401 gatatttggt cggaaagatc agcgatcaag cgcaactcta agtgttcaat cgttgtcagt 557461 tcttttacac aatattcaat atgatttttt ataacataat atctcgaatt cgagataaaa 557521 gggagtgtag cgtaatggct gaatttactc atttagtcaa tgaaagacga tctgcaagca 557581 attttctttc aggtcatcca atcacaaaag aagatctcaa tgagatgttt gaattggttg 557641 cattggcacc atcggctttt aatttgcagc atacaaaata tgtgacggtt cttgaccagg 557701 acgtaaagga aaagctgaag caggccgcaa acggacaata taaagtggtt agctcttctg 557761 cggttctctt ggtattaggg gataagcagg catatcaaca agcggccgat atctatgaag 557821 gtttaaaggt attggggata ttaaataagc aagagtatga ccacatggtg caagacaccg 557881 tttcgtttta tgaaaacagg ggagaacaat ttaagagaga tgaggcgata aggaatgctt 557941 cactttctgc gatgatgttt atgctgagtg ctaaggaaaa aggctgggat acctgcccga 558001 tgatcggctt tgatgcggaa gccgtaaaac ggattttgaa catagacgac caatttgagg 558061 ttgtcatgat gattacgatt ggaaaagaaa aaacagagag cagaagaccg cgcggctacc 558121 ggaagcctgt gaatgagttt gttgagtata tgtaaaagga gcggataaaa atggctaaaa 558181 aaacgatggg aattcatcat attacagcga ttgtcggtca ccctcaagag aacacagatt 558241 tttacgcagg agtgcttggg cttcgtttgg tcaagcaaac tgtcaatttt gatgacccag 558301 gtacgtatca tctttatttt gggaatgaag gcgggaagcc gggaacaatc attaccttct 558361 ttccgtgggc cggagcccgc caaggcgtca ttggagacgg tcaagttggc gtgacttcgt 558421 atgtcgtgcc gaaaggggct atggcatttt gggaaaagag actagaaaag ttcaacgttc 558481 cctacaccaa aatcgagcgc tttggggaac aatatgtaga atttgatgat cctcatggac 558541 tgcacttaga aatcgtggaa agagaagaag gagaggctaa tacgtggact ttcggagaag 558601 taacgcccga tgttgccatt aaaggttttg ggggtgcaac cctattatca gagcagcctg 558661 acaaaaccgc tgacctttta gaaaacatca tggggctgga gcgagtcggc aaagaaggag 558721 acttcgttcg ttatcgttcc gccggtgata tcggaaatgt gattgacctt aagttaacgc 558781 ctattggccg cgggcaaatg ggggccggaa cggtgcatca catcgcttgg cgggctaacg 558841 atgatgaaga tcagttagat tggcaaagat atattgcttc ccacggatat ggtgtaactc 558901 ctgttcggga tagaaactac tttaatgcca tttacttcag ggaacacggg gaaatcctgt 558961 ttgaaatcgc aactgatccc ccaggctttg cacatgatga aacacaggaa acaatgggcg 559021 aaaaactgat gctgcctgtg caatatgaac cgcatcgcac acaaattgaa caagggctgc 559081 tgccgtttga agtaagagag ttagattgat ttgacacata aaaaataaag aaacatatat 559141 tcaattgatg attgctggat ggtactgtca gcaaagaatc agataaaatc aaagatgagg 559201 agagatacaa atggaagatg caggactgtt gcttattcgt ataatgattg gtgtggtgtt 559261 tttgttttat ggcacacaaa aattattcgg ctggtttggc ggatacggga ttaaaggaac 559321 cggacaatgg ttcgaatcaa ttggggtgaa accaggaaac gttgcggccg ctctatcagg 559381 tcttggggag ttagtaagcg gaattctatt tattttaggc gtattcctcc cgcttggagc 559441 tgctatcata acaatcatca tgttaggtgc tatcgtaaaa gtccatggag cgaaaggttt 559501 tgcgaatggc gccggaggtt ttgaatataa cctggtgctc attgcagttt ccataggggt 559561 tgcactcatc ggttcaggag cttacgcttt gcatttttaa tacgaaagta tgtaagaaca 559621 gttgctgctt gtcagtaact gttcttttat tttcacattt tcggcaagct tgcaggtact 559681 ctgcaaagca aaaaagcgga tatcataaat ataaatctgt atagtgaatg atacgtattg 559741 atgagcttgg tcatgaaaaa cagacctatt tgaaggagta aatggatgaa agagatgaca 559801 ggattacatt cattagtttc tatagaaaac tttatcaaac agcacaaatt cagttttatt 559861 tatatatcaa ggcctggctg tacagtatgt cacgcagttc tgccccagct cagaatagta 559921 ttggatcagt ttccaaacat caaattgggg catatcaatg ctgacgatgt agcagaggtc 559981 gccggcagat tttcagtttt caccgttcct gtgcttcttt tgttcattga tgggactgag 560041 tttctaagag aagcccgttt tgttcatttt gaacagcttg aacaaaagct gaaaagggtt 560101 tatcgattat atgaaggcga ataaaggaat aaggcaaaaa aagaactcaa atgagttctt 560161 tttttattct tcactaggcg aagaagggtt atcaacctgc ccttgatcac ttgtatcatt 560221 atcacaactt gctgaaataa taattgaatg agaaggagag taatctccta atgtgaaatt 560281 cactccgtaa tttttgctgt tcgcagtatg gctgttttgc aagttttgtc cgatatctgt 560341 attggcgttt tgtgtcattc catttatcgt gagatttgag atgttgattt gagatcgcat 560401 gcttcaaaaa ctcctttcac tcagaagtag ctgtcataaa ggacgctggc agtctattta 560461 cttctatgat attgcgtttt tatatcattg catcaacata atggtaaaaa taatagcgag 560521 tgaatgatca tcttttgaag atgatcaacc tatcagcaga aataaagccg cctgataaag 560581 aggcggcaga tcgttatatg tcatctatga atttgatgta tcgtttttcg tttgcctgaa 560641 ggataagata gtcgttttta atgatgagta ggagcctata gcagcgtagc cataaaacca 560701 gcccataaat acgccagaaa agaggctgtg tcgatggctt atgaaaacag aaatgacaag 560761 gcctgttatt aaggcaactg acggtacaaa agttttgggg attttcaata atattttgag 560821 gatttgggtt atcaatatga tgattggaac agctatcaca gcatcccaaa agttcgtgtg 560881 aataattgga aaagccatac ggcacctcat gaagtgttta tttcttaatt tttacgctaa 560941 aagcttggaa agcagctctt ggatcgcata tgttacattt tgggcttgat tggcggagct 561001 tgtttggctt aaagcattgg attcaaaaac caaacctgta ttactcccac cggaaccctc 561061 tgttgtttta gacacagaga acgggctgat ggaaactgca aatccgttat taaaaacgct 561121 gttcccggat atcgaatgaa tataaactgg gaatttcatc attcatctct cctctctgtt 561181 atgactgttt atacaatatg gtgtgtgagc agcagttgct taaacaaaac ggcaaaaact 561241 ttcagtaaga gacaaaaacc tgcaaaatgc cacaagcgcc ttttgttaat gcagcttttt 561301 agggacgttt tttttatttt ttttgccaac ttcatcaaaa atattctgat tgccagactg 561361 ggcttgtccg tccttattta tgaaatcggg gtgaatgagt tttttcagat ccctgactgt 561421 taaaggcttg gcgtcatcag ttaattctat tcctaattgc ccgtttgcct ctaatgtcgc 561481 aattttgaca tcttgtatag ccgtaacgcc gtgaagcctt agctgcattt caagctggtc 561541 agctgtaagt ctcatcttct ttaagttttc gatatgaagc tgtccgtttt caatgacgat 561601 ttttgctttt ccggttaaca tcttttcaat ggtgttcgat ttcatttgga tccattccat 561661 aacgatgagt gtgcttgtga aaattgccgc tgcaattaat gttttgaaga ggctgtactc 561721 gatgattggc tgaacgataa tagttccgat cgaaatcatg acaaccgttt gagtcgacgt 561781 catttgtgcg attgatttcc ttcctgaaat tctcagcaaa atgaccccgg ctacaatgag 561841 aacaagagat tcccaagtga aattcatgct accacctgac caatgatgaa ttagatttgt 561901 catgggattg gcttttcttc cggccaatcg caatttaata tatccgaaag gcagtcggtt 561961 cattctgtcc tgaaccgaac aatatttttg gtatagatgg atatattaag ccaaacaatg 562021 atagcaacag gagttttttg gccgaaacaa tctgggaagc ggggagcgcc ataacatgat 562081 tgaacttgaa gttgtcatta gaacggttgc cagctttggc ttgctgttaa tcgcagaacg 562141 aattttaggc aaacagacaa tctctcaaat gacgattttt gattttattg cggcgatcac 562201 actaggggcg attgctgccg gattagctta caatacttca ataaaaccgc acaatatggc 562261 catttcgttt agtatttttg tgctaaccat ttttctaatt tcgtttctgt cgataaagaa 562321 caggaagctg aggaaatttt ttgccggaga tccaacagtg ctgattcaaa acgggaagat 562381 acttgaatca aatatgagga aaatgcgtta cacacttgat tatttaaatc agcaattacg 562441 ggaaaaagaa atatttaata tcgaagaagt tctttttgcc attcttgaaa cgaatggtca 562501 gctgactgtg ttaagaaaac cgcaattccg gcatgtgacc aaacaggatt taatgattgc 562561 ggtaaaccaa gaacaaaggc ttccgataga acttattatg gacggagaaa tcattgagaa 562621 taatttaaag cagaatcgtt tgacggaatc ctggcttttg gaagaattgc gaaaaagaga 562681 cataaaggtg aaagagaccg tgtacgcagt gctgctgggt aatggggata tttatgtgga 562741 tcaatataaa gaccatatat cagtccctat ggataaggaa tgaaggaaca atcaatctta 562801 aagcccctta ttgaacgcaa cggtttcaac ttgtcttggg tacgaaatat gcagaagccc 562861 gtttaacagc tgaatctgta acaaatgagt ttcagcggct tcgggaagct gaatgattcg 562921 ctcaatttct ccgtaatacc gttcacgcag cacttccatt tcggctggaa aaacaggcgt 562981 gatcgttcct ttgatcagca gctgggtttt agacagtaaa cggatcgtta attcttcctc 563041 atacacaccg ggcatttcca caatgataaa attatattcc tcatcttgat aaaagtcgta 563101 aacaaacgta gaagcttcgg aatcaaaaaa atgttccggg gctttatatt tgagcacatt 563161 tgtccaaaag tcactttgtt tatattcatt cgtaatctca agccactttc gaattttttc 563221 gaaatccata tgagattctc cttaaatttg atttgaaatc ggcgcagaag ggtttccgat 563281 ttggtcttgg tcactaacgt ctgaatcaat atttccagtg tttaaaagtg aagacgtagg 563341 cgaaagatcc cctaaggaaa agtttgctcc aaaatatttg ctgttcgcag tatggctgtt 563401 gtgcacagtc ggaccgacat ctatatttcc gttttgcgtg acgccgttga tcttaatatt 563461 tgcgatatta atttgatatg gcatagacga aaccccttta atctaaaatt ggcggtggtg 563521 caatcggagg agcattaacg ttggatgtat cagagttgcc gatagatgtc tggtcattta 563581 catcaggatc gtttaagaag ttttccatta cggattctgt aggtgatgta tcaccgaaag 563641 aagagttggt cccttgagat ttttgattgt tggtagggct gttataagca gcttcgccta 563701 ttgtaattga accattgccc gaaatactgt tgatcttcaa ataatatagg ttgattactg 563761 tagacggcat cccatcacac ccttccatct ttctgtacag tacattatgc gccgctgcac 563821 ccaattgttc cttgcattta cgggcaaaac tctatctggc cccggagtga tgctcaatta 563881 tcagtgaatg aaaagccatt gatataggaa tcaatgaatt gattcagtta ttcgaaatgc 563941 atgagacctt ttaataaagg aagctggcaa acaggatcag tttgaaataa ttgacaatga 564001 agctaatgcc atgaaataat actcgtgagt aacattactc gtgggtatta tttttggggt 564061 ggtcctagtt gaaaagtaaa ggagtagaaa gccgaaaacg attacttaaa gctgccgcta 564121 atgaattttc ggttcgggga ttccatgacg cgaaggtaag tgaaattgtg aaaaaagctg 564181 ggttcacgca gccttcattt tacctgtact ttcaaagcaa agaagccatc tttgccgagt 564241 taataaccga ttttcactct cgagtcagaa agctgacaga gtcacttctt ctggaaaacg 564301 gattaaacac ggaggatgtg tcaaaacggg tactgctagc tgtagagact gtttttcaat 564361 ttttggatga ggacaaggat ttaaccaaga tcggcttttt tctcaacccg gaagcaaaac 564421 aaatgaaaaa agacttggcg atggttttga aagagaactt agaagcagaa cagcggcttg 564481 gctattttca ctctgaactg gatatggaaa ctgtcgctga gtgtttggtc ggcatgattg 564541 aacatttaac cgaatcattt ttgttaaccg gaatcaaaga tccggcaagc ctcgcagcag 564601 aggttgtgaa tcttttaatt tacgggatgc ttccgaaagg gaatgatgta agatgatatc 564661 tattatgatg aaagtcagtt tggcagtttt tatgcttgcg ggaggcatca taaaggtaag 564721 ccgcgttccc tttcaagttg agcattggcg gcattatcaa tatccattat ggtttctgac 564781 tgttactggc attcttgaaa tagccggggc acttgctatg acagcgggaa tttggaatcg 564841 gtatgcagca attggagcag gtgttctgtt tgtcgttctc atggcgggag caattcatgc 564901 gcatatgttt cgagcaagac aatctgtcat catggcgata caagcgatga tttgtttgat 564961 tgtttcaatc atgatcatca tggggagtta cacgtaagct tttcactaat gtttaagaac 565021 aagcccattt gcaggaaatc tccttttctt atcgaataat agaaagtcca ggaattaact 565081 gaatcagtaa aatagagctc catttctgtg ttattcgtcc ggcatcagct gggctttttt 565141 tataaaggag gaatacagga tggcattcac tttggaagac atgactgagg aagagttcga 565201 agcctttcgc gggatgtccg tgcaaaattt tgcgaaacaa aacataacgt caggaacttg 565261 gacggaaaaa gaggcatttg agaaatcgga gcaggcatat gagaacatga ttccgaatgg 565321 gcgagacagc agcaatcatt atttttggaa catcacaaat gaccaaggag aaagaatggg 565381 ctggctctgg ctgtatgctg atccattaca tccgcaaaag gaagcgttta tctattcctt 565441 tggattgtat gaagcctttc gcggaaaagg acttgctcaa ttggcgcttc aaacgcttga 565501 tgaaagagca agagagcttg gtgcggaaag gctggctcta catgtatttg cacacaacga 565561 gacagccgtc tatctttatc agaagatggg ctatgccatg accaatatac gtatgcggaa 565621 acagctatgc tgaaaagccg cttacgttac ccaaatacaa catgcctatc tggaagcggt 565681 ggcagggtac tataagtcat cattagaaag attaaggtca tgggaggctt gaacatataa 565741 agaaaaagga caacagctgt tgtccttttc aatgccgctt gaactttctc cctcagtctt 565801 ttttgtcttg atgatccagc tcttttattc gtttcgtaag ctcattgaaa gcctgatcaa 565861 gctccttata ccctttatca tttggcgtca taaaactgag ctttcccagc acttcttgtc 565921 tttctgtctc aagctttaac cgaagctcct cccgctcatt tctttctgaa ggaacgtcgt 565981 ttaactgctt ttcgatgccg ttgtttgaga tgacgagttt actgtttgtt gttttttcga 566041 gaaagtatcg gtcatgtgaa accgccagca atgtgccgct gtattgtgac agtgtttctt 566101 ccagctgttc gcgtgacggc aggtcgagat ggtttgtcgg ctcatctaaa atcagcacgt 566161 ctttttcctc cagaatatat gccatcagct tgatctttac acgctcaccc atactcatat 566221 gcttgatcgg ttcagtccat tgggcggctg taaaacctaa gtgcctcatc agattttgaa 566281 cgtgccccct tgctttgaat gtttcattct caaataactc ttccggtgtt tgttctaaag 566341 gcaaatcaaa cacctcctgc gttaaatagc cgatgtttgc ggacggcgac acccatacac 566401 ttccttctgc tgtttcctgt cccagaatga tgttcagtaa tgtcgttttt ccgctgccat 566461 tggggcctat gatcgcaacc ttttcgccgt gctgaattgt aaagtttgcg tttttaaaga 566521 gagtcctttc tccaaacgct tttgttacat tctgaacttc taaaaaacgt tttcctgttt 566581 tgtgggttgt atcgattgaa aagcggactg tatattctgg ggtaacgggt tccgcctttg 566641 ctttttcaag ctctttttca agccgcttct gcttggattt tatctgggca tccgtacgct 566701 tcgcttttac ccggtgatat tctttaaacc cttccttttt cgtcgattga gcatgggctt 566761 tttccgacca agaagcgagc ccattcattt gtgcttcaat ccgttcaacc attttttgct 566821 gcttttcata ttcacgctgc tgggtgagtc ttttcttctc ccggaacttc atatacccgg 566881 agtaattccc tttgaattca atcagcgtct gatcctcaag cgaccatatt tttgttgcgg 566941 cttcgtctaa aaaatatcga tcgtgagaaa cgagaatcac agtgccgtta taatgtttca 567001 gctgttggat gagaaattgc aagctttttt catcaaggtg gtttgtcggt tcatctaaca 567061 gcagcagatc tgcatcctct gatagtcctt tcgccagccg cgctttcagt ttttcaccgc 567121 cgcttaactg atgaaaatca cgaagaggca catgccattt ctccagtaac ttcttttcgg 567181 caggtgtctg atccgcaaag gaatacgccg cggtttcctg ttcaaccaaa gccagtttta 567241 tatccttccg aaggatttga ccctgtgcag gggctaagtc attgtgaatg aggtgcagca 567301 acgtagattt cccagcgccg tttttgccga taatcccaat gatatctcct tgctgaacac 567361 tggcgtttac atgtttaaaa acagtttgat cctttacttc atagctaacg tttgttaatg 567421 ttacgatctc tttcatccat atccctcgct ttaaagggag aataaaaaaa tcctcccaaa 567481 tgtgttggaa ggattagccg tgcctgtgca tgatcaaata agctattttt tataaatagc 567541 agtgtcgtat atatagaaaa tgggcagact aatcctattt tttgatttga aatattgatt 567601 tcaaacggta aaaataagat tagttaatca ttgtccaccc atcatccctt cttgttttga 567661 ttacaaacac tatagcatac ctttaaattc aaaagcaaag gtcattttca tcaaaaaaac 567721 tcctgctctc atttttgagg caggagtttt gagtcttatt gatgcttcgc ttttctcact 567781 ttataaatca caatcagcaa aataaaccaa accggtgtga caaataagga aacacgagta 567841 tcctgtgcca gtgccagcac aaccagaaca aacgccagga acgcaagaat caggtaattt 567901 gtaaacggat aaagcggaag cttaaacttg tttgttttcg ctaattcagg tcttgttttg 567961 cggtatttca tatggcagat gaccgtaatc ccccaaatgt agataaagca tacggttgaa 568021 atacttgtga tcagggtgaa tacgccttct ggcatgatgt agtttaacgt aacaccgatt 568081 aaaatcacga tagctgaaaa gaataaagca tttctaggca ctttacgctg agtcagtttc 568141 gccattgact caggcgcatt gtgatctttc gccagggaat agaccatacg gcttgtactg 568201 aatacagcgc tgttgcatgc tgaagcagcg gatgtcaaca caacaaagtt gataatactt 568261 gcagccccga cgatgccaac agcgacaaat acttgtacga atgggctttc gctgggattg 568321 atgatatccc aaggatagat gctcataatc acgagaagag ccccgatata aaaaagcagc 568381 acacggacag gaatattgtt gatcgcctta gggattactt tttcagggtt ttctgtttca 568441 ccggccgtaa gcccgacaag ctcaatgccg acaaaagcaa acacaaccat ctggaacgag 568501 aggataaacc cgtgcatgcc attcgggaac aggcctccgt ggctccagag gtttgtgaag 568561 ctggacactc ctgagcttgt ggaaaagcct ttgaaaatca tcacaaggcc aatgacgatt 568621 aacgccaaaa tggcaatgac tttaatcaaa gcgaaccaaa attctaattc tccaaaaagc 568681 ttgactgtcg ccagattcat aatcagtaaa ataataagag cgattaagcc aggcacccat 568741 tgcggcacac ccgggagcca atattgagtg tagagcccga ctgctgtcag atcagccatc 568801 gcaatggaaa tccagcagaa ccaatatgtc cagccggtga taaaagctgc catatcgcct 568861 aggtagtctt gtacaaaatc cacaaaagag tgatagttca agtttgataa cagcagttca 568921 cccagcgatc tcataattaa aaagcaaatg atccctgtga tcatataagc aaataaaatc 568981 gaaggtccgg caaaatgaat cgatttgccc gagccgagaa ataagcctgt cccaatggct 569041 ccgccgatgg cgatgagctg gatatgcctg tttttcaagc ctctctgcaa cgtttgctga 569101 tttatattgt ctttcgtcat gtcgtctgtc actttatgtg ttcctccatt gaaaattgtt 569161 tattgagtca gcaatctatt tttaatgatt attataacac taaaatttct atctttttta 569221 ctaaaaaagg attgatgaaa agaattttaa tgtgatttgg actatttccc gaaaaaagcg 569281 gctccattta gggagccgct tttttatgct ttttcagttt ttgtcataaa caggtagagc 569341 ccgtaatctg tcggtgcgga tgcgtagcct gcctgccgca gcattgctgt gatattgccg 569401 cggtggtatg tcccgtgatt gacaacgtgg ggaagcagtt cggaaacagt tgttttcatg 569461 attccgcttg agggattttg aatctggagt ggcttattga gctgttcttt ttgctgtaaa 569521 aatagtatat agcgctcgga taacctcaga aaaaggtctt ccatttcctc tatttcttta 569581 gcctctgtct gttctttaag ctgttcagct aaagccaacg catcgctcaa ggttttgccg 569641 gaaaacactt caatccagcc gagatcagaa agataaacat gagacaatac atgggatatt 569701 gacggaaaca cgctttgaat ttcttgatgg tatatctctt ttggaagctc ttttaatcgg 569761 ttgaatattt gttgattggc ccagacgtta tattcataca atttgaatgc aaaatctgac 569821 atgttaaaat tccccctttc gtgtgtatag ctttcattat acacgaacat gagttcttat 569881 gtagagtgct cgaaaataaa atttgttgac atatatagtt tagaggaata aactaattga 569941 cattgaacat aaagtttagc ggggtaaact ataatgcgtc tgattagagc tcatttcata 570001 aattcttgtt ttttgcagca cacctgtcga ctcaagaagc aggttatcca gcaggtcagt 570061 aattaagttt ccgtggttat acacccacga cccgttccac ggattgcccc ctgcatcaac 570121 aggaagggaa ctttgcgctc caataatata atgatgagga ttagcatgtt taaccgcttc 570181 atcaagtggc gcttgatctg taccttgact gccgacacct tcaccgcctg attcatctaa 570241 taaagcattg attgtgtttt gaaccagttc aacgtgggca atctcctcta aaaaaatgcc 570301 gcgaagcaga tcgcggtact gtttctgctt tcctctgaaa ttagagcttt ggaaaaaaac 570361 tgcatcattg tacgcatttc tccgtaatga ccgcctaata tctcctgcag gaccttagca 570421 gctgccgggt ctggcttgtc cggtttaatg atattaatca gttcctcttt gtagtaatac 570481 ataacacgcc tcatttcttc ttaagagatt ttcttatatt atttgtaaga tgagataaaa 570541 tatatacatg ataagcatgg gaaggcgtga aagaagaaaa taaaaaaata caggaaaagt 570601 gttgaccaaa taaaacaggc atggtatatt attaaacgtc gctgatgaac agcgtgaaac 570661 aaaacagaaa aacaaaaaag ttttcctaag gtgtttacaa gattttaaaa atgtgtataa 570721 taagaaaagt cgaattgaaa aagattcgaa aaaacattaa aaaacttctt gacttcaaca 570781 tcaaatgata gtatgatagt taagtcgctc aataagcgcc cgtagctcaa ttggatagag 570841 cgtttgacta cggatcaaaa ggttaggggt tcgactcctc tcgggcgcgc catataagat 570901 accacgcggg tgtagtttag tggtaaaacc tcagccttcc aagctgatgt cgtgagttcg 570961 attctcatca cccgctccat tattgaatga tctttgaaaa ctaaacaaga caaaacgtac 571021 ctgttaattc agtttttgaa aatcgcacag cgatgtgcgt agtcagtcaa actagggcct 571081 gcacgatgca ggtcacacag gtgtcaccgc gggatgcggt ggacttaacc tgtgatccat 571141 ttatcggaga gtttgatcct ggctcaggac gaacgctggc ggcgtgccta atacatgcaa 571201 gtcgagcgaa cagatgggag cttgctccct gatgttagcg gcggacgggt gagtaacacg 571261 tgggtaacct gcctgtaaga ctgggataac tccgggaaac cggggctaat accggatggt 571321 tgtttgaacc gcatggttca aacataaaag gtggcttcgg ctaccactta cagatggacc 571381 cgcggcgcat tagctagttg gtgaggtaat ggctcaccaa ggcaacgatg cgtagccgac 571441 ctgagagggt gatcggccac actgggactg agacacggcc cagactccta cgggaggcag 571501 cagtagggaa tcttccgcaa tggacgaaag tctgacggag caacgccgcg tgagtgatga 571561 aggttttcgg atcgtaaagc tctgttgtta gggaagaaca agtaccgttc gaatagggcg 571621 gtaccttgac ggtacctaac cagaaagcca cggctaacta cgtgccagca gccgcggtaa 571681 tacgtaggtg gcaagcgttg tccggaatta ttgggcgtaa agggctcgca ggcggtttct 571741 taagtctgat gtgaaagccc ccggctcaac cggggagggt cattggaaac tgggaaactt 571801 gagtgcagaa gaggagagtg gaattccacg tgtagcggtg aaatgcgtag agatgtggag 571861 gaacaccagt ggcgaaggcg actctctggt ctgtaactga cgctgaggag cgaaagcgtg 571921 gggagcgaac aggattagat accctggtag tccacgccgt aaacgatgag tgctaagtgt 571981 tagggggttt ccgcccctta gtgctgcagc taacgcatta agcactccgc ctggggagta 572041 cggtcgcaag actgaaactc aaaggaattg acgggggccc gcacaagcgg tggagcatgt 572101 ggtttaattc gaagcaacgc gaagaacctt accaggtctt gacatcctct gacaatccta 572161 gagataggac gtccccttcg ggggcagagt gacaggtggt gcatggttgt cgtcagctcg 572221 tgtcgtgaga tgttgggtta agtcccgcaa cgagcgcaac ccttgatctt agttgccagc 572281 attcagttgg gcactctaag gtgactgccg gtgacaaacc ggaggaaggt ggggatgacg 572341 tcaaatcatc atgcccctta tgacctgggc tacacacgtg ctacaatgga cagaacaaag 572401 ggcagcgaaa ccgcgaggtt aagccaatcc cacaaatctg ttctcagttc ggatcgcagt 572461 ctgcaactcg actgcgtgaa gctggaatcg ctagtaatcg cggatcagca tgccgcggtg 572521 aatacgttcc cgggccttgt acacaccgcc cgtcacacca cgagagtttg taacacccga 572581 agtcggtgag gtaacctttt aggagccagc cgccgaaggt gggacagatg attggggtga 572641 agtcgtaaca aggtagccgt atcggaaggt gcggctggat cacctccttt ctaaggatat 572701 tatacggaat ataagacctt gggtcttata aacagaacgt tccctgtctt gtttagtttt 572761 gaaggatcat tccttcgaaa cgtgttcttt gaaaactaga taacagtaga catcacattc 572821 aattagtaat acaagatatc acatagtgat tctttttaac ggttaagtta gaaagggcgc 572881 acggtggatg ccttggcact aggagccgat gaaggacggg acgaacaccg atatgcttcg 572941 gggagctgta agcaagcttt gatccggaga tttccgaatg gggaaaccca ccactcgtaa 573001 tggagtggta tccatatctg aattcatagg atatgagaag gcagacccgg ggaactgaaa 573061 catctaagta cccggaggaa gagaaagcaa atgcgattcc ctgagtagcg gcgagcgaaa 573121 cgggattagc ccaaaccaag aggcttgcct cttggggttg taggacactc tgtacggagt 573181 tacaaaggaa cgaggtagat gaagaggtct ggaaaggccc gccataggag gtaacagccc 573241 tgtagtcaaa acttcgttct ctcctgagtg gatcctgagt acggcggaac acgtgaaatt 573301 ccgtcggaat ccgggaggac catctcccaa ggctaaatac tccctagtga ccgatagtga 573361 accagtaccg tgagggaaag gtgaaaagca ccccggaagg ggagtgaaag agatcctgaa 573421 accgtgtgcc tacaagtagt cagagcccgt taacgggtga tggcgtgcct tttgtagaat 573481 gaaccggcga gttacgatcc cgtgcaaggt taagcagaag atgcggagcc gcagcgaaag 573541 cgagtctgaa tagggcgcat gagtacgtgg tcgtagaccc gaaaccaggt gatctaccca 573601 tgtccagggt gaagttcagg taacactgaa tggaggcccg aacccacgca cgttgaaaag 573661 tgcggggatg aggtgtgggt aggggtgaaa tgccaatcga acctggagat agctggttct 573721 ctccgaaata gctttagggc tagcctcaag gtaagagtct tggaggtaga gcactgattg 573781 gactaggggc ccctaccggg ttaccgaatt cagtcaaact ccgaatgcca atgacttatc 573841 cttgggagtc agactgcgag tgataagatc cgtagtcgaa agggaaacag cccagaccgc 573901 cagctaaggt cccaaagtat acgttaagtg gaaaaggatg tggagttgct tagacaacca 573961 ggatgttggc ttagaagcag ccaccattta aagagtgcgt aatagctcac tggtcgagtg 574021 actctgcgcc gaaaatgtac cggggctaaa cgtatcaccg aagctgcgga ctgttcttcg 574081 aacagtggta ggagagcgtt ctaagggctg tgaagccaga ccggaaggac tggtggagcg 574141 cttagaagtg agaatgccgg tatgagtagc gaaagagggg tgagaatccc ctccaccgaa 574201 tgcctaaggt ttcctgagga aggctcgtcc gctcagggtt agtcgggacc taagccgagg 574261 ccgaaaggcg taggcgatgg acaacaggtt gatattcctg taccacctcc tcaccatttg 574321 agcaatgggg ggacgcagga ggatagggta agcgcggtat tggatatccg cgtccaagca 574381 gttaggctgg gaaataggca aatccgtttc ccataaggct gagctgtgat ggcgagcgaa 574441 atatagtagc gaagttcctg attccacact gccaagaaaa gcctctagcg aggtgagagg 574501 tgcccgtacc gcaaaccgac acaggtaggc gaggagagaa tcctaaggtg atcgagagaa 574561 ctctcgttaa ggaactcggc aaaatgaccc cgtaacttcg ggagaagggg tgctctgtta 574621 gggtgcaagc ccgagagagc cgcagtgaat aggcccaggc gactgtttag caaaaacaca 574681 ggtctctgcg aagccgtaag gcgaagtata ggggctgacg cctgcccggt gctggaaggt 574741 taagaggagc gcttagcgta agcgaaggtg cgaattgaag ccccagtaaa cggcggccgt 574801 aactataacg gtcctaaggt agcgaaattc cttgtcgggt aagttccgac ccgcacgaaa 574861 ggcgcaacga tctgggcact gtctcaacga gagactcggt gaaattatag tacctgtgaa 574921 gatgcaggtt acccgcgaca ggacggaaag accccgtgga gctttactgc agcctgatat 574981 tgaatgttgg tacagcttgt acaggatagg taggagcctt ggaaaccgga gcgccagctt 575041 cggtggaggc atcggtggga tactaccctg gctgtattga ccttctaacc cgccgccctt 575101 atcgggcggg gagacagtgt caggtgggca gtttgactgg ggcggtcgcc tcctaaaagg 575161 taacggaggc gcccaaaggt tccctcagaa tggttggaaa tcattcgcag agtgtaaagg 575221 cacaagggag cttgactgcg agacctacaa gtcgagcagg gacgaaagtc gggcttagtg 575281 atccggtggt tccgcatgga agggccatcg ctcaacggat aaaagctacc ccggggataa 575341 caggcttatc tcccccaaga gtccacatcg acggggaggt ttggcacctc gatgtcggct 575401 catcgcatcc tggggctgta gtcggtccca agggttgggc tgttcgccca ttaaagcggt 575461 acgcgagctg ggttcagaac gtcgtgagac agttcggtcc ctatccgtcg cgggcgcagg 575521 aaatttgaga ggagctgtcc ttagtacgag aggaccggga tggacgcacc gctggtgtac 575581 cagttgttct gccaagggca tcgctgggta gctatgtgcg gacgggataa gtgctgaaag 575641 catctaagca tgaagccccc ctcaagatga gatttcccat tccgcaagga agtaagatcc 575701 ctgaaagatg atcaggttga taggtctgag gtggaagtgt ggcgacacat ggagctgaca 575761 gatactaatc gatcgaggac ttaaccatat ttttgaatga tgtcacacct gttatctagt 575821 tttgagagaa cactctcaat ttgtttggtg gcgatagcga agaggtcaca cccgttccca 575881 taccgaacac ggaagttaag ctcttcagcg ccgatggtag tcgggggttt ccccctgtga 575941 gagtaggacg ccgccaagca ttacttttat catcgcgggg tggagcagtt cggtagctcg 576001 tcgggctcat aacccgaagg tcgcaggttc aaatcctgcc cccgcaacca aatatatggt 576061 taaataagga gtgccctaag ggtgcaacca aaataatcct atacaaatat ggtccggtag 576121 ttcagttggt tagaatgcct gcctgtcacg caggaggtcg cgggttcgag tcccgtccgg 576181 accgccatta atgtaaacga aacgatcatg ttttcgtttt ttttgtgttt tcttttactg 576241 tatcttctgc ttggtgtcat agccaagctt tctttatatc gggaacatct tggatattcc 576301 agcaaaattc gataaactag gaagagcaca aataggcata agcagggttg aaaggaggtt 576361 ttggttcatg gatgaatttg atttgataca tagcattact ccgcggacca ttcaccattc 576421 ttccgttgat gtaggaatag gtgatgatgc agcgctctac actgcgaaac acggcgttca 576481 ggaaattgtt tgtgttgata ctatggtaga agacgtgcac ttcaaattac actattcctc 576541 acctgaagat atcgggtaca aggcgttagc cgttaatata agtgatattg ccgcgatggg 576601 aggcattcct aagttttatc tggtatcact tgcggtacct tcaaaatgga ctgaatctga 576661 aatcaaggcg atgtatgaag gaatgaatga actggcgaaa ctatatcata tggatctgat 576721 tggcggcgat acagtttcta ccgctgacaa attagtcgtt acagtcactg taatcggtga 576781 aattgaaaag ggacaggcct gtttgcgcag cttggcaaaa ccgaatgata ttgtgtttgt 576841 aaccggtgaa atcggttctt ctgcagcagg gctttcttta ttgctggaag agactaatcc 576901 tcaaaactca tctgtggaaa cggattactt tatccacagg cataaacggc ctgagccaag 576961 agtaagcgtc ggcagattat gctcgatttt taaacgggca gctttaaatg atgttagtga 577021 cggattggct agtgaactga acgagattgc agaagccagc tgtgtttcaa ttgaaattgt 577081 tgaaagcatg cttccaattc attctgattt gcctaagctt catcctaact ggaaagaatg 577141 ggctttgttt ggcggtgagg attttgagct gacagggacg gtttcaaatg aggagtggga 577201 agtgttgaag caggagtgcg cagcgcttca tcttcccatt acaaagattg gctatgtcag 577261 ggaaaaaaca aaatctaaag tgatcctaaa aacagatcaa acatcaatga tcttagagaa 577321 aaagggatat aatcatttta aataagacgg gtgactcgtg tgaagcaatt aaaatggaga 577381 actgtaaatc cagaagaaac aaaagcaatt gccaagctga cggcagcgtt tgctaaaccg 577441 ggagacgtcc tgacattaga gggcgattta ggtgcaggaa aaacgacttt tacgaaaggt 577501 tttgcagaag ggctgggaat tacacgtatt gtaaacagtc cgacttttac aattataaaa 577561 gaatataacg atggcgtact tcctctttat cacatggatg tgtatagaat ggaagatgaa 577621 agtgaagatt tgggacttga tgaatatttt cacggacaag gtgtctgtct cgttgaatgg 577681 gctcatttaa ttgaagaaca gctgccacag gagcgactgc aaattgtcat caaaagagct 577741 ggtgatgatg agcgggaaat tacctttact gctgtcggga atcggtatga aatgctttgt 577801 gaggagttaa gtagacatga caatattagc aattgataca tcaaattata cattgggcat 577861 tgcgctgctt cgagaagaca ctgttatagc agaatacatt acatatttga aaaagaacca 577921 ctctgtaaga gcgatgcctg ctgttcattc attgctgaat gattgtgata tggcaccgca 577981 ggacctttct aaaattgtcg ttgcaaaagg ccctggttca tacacaggag taagaatagg 578041 tgtgacgttg gccaaaacac ttgcctggtc tttagacatt ccaataagtg ctgtatcaag 578101 tcttgagacg cttgcggcaa atggccggca ttttgacggt ctgatcagcc caatctttga 578161 tgctagacgg ggacaggtgt acacaggtct gtatcaatat aaaaatgggc ttttagagca 578221 agttgttcca gatcaaaatg tgatgctggc agattggctg gagatgctaa aagaaaagga 578281 ccgccctgtt ttgtttttag gccatgatac ttctcttcac aagcagatga tcgaggatgt 578341 gcttggaaca aaaggattca ttggaactgc cgcccagcat aacccgcgcc cttcagaatt 578401 ggcttttctc gggaaggaaa aggaagcagc tgatgttcat gggcttgtcc cggattactt 578461 gcggctggca gaagctgaag cgaaatggat tgaaagtcaa aagtagggtg ataggatgaa 578521 aacaaaagca gcggtcagaa atatgcggct tgaagatata gatcacgtat acgaaatcga 578581 agcatcctcc tttacgtctc cttggacgaa ggattcgttt tatcatgagc tgctggaaaa 578641 tccgtatgct cattatctcg tgattgaaaa ggacggccat cttgctgggt attgcgggat 578701 ttggattgtg atggacgatg cccagattac aaatatagcg ataaaaccag agtatcgcgg 578761 ccagtcttta ggagaaacgc tttttcgctc agctgttgaa ctgtgcaaag aaaaagacgc 578821 aaggcggctt tcgcttgaag tgagggtttc gaatcatcct gctcaaggct tatataagaa 578881 attcgggatg cagcccggcg gaataagaaa gaactattat actgataacg gggaagatgc 578941 gttaattatg tgggtgacga taaatgagtg agcaaaaaga catgtacgta ttaggaattg 579001 aaacaagctg tgatgagact gctgcagcta ttgtgaaaaa cgggaaagag atcatttcaa 579061 acgtagtagc ctctcaaatt gaaagccata agcgcttcgg aggcgttgtt ccggaaattg 579121 cttcaagaca tcatgttgaa caaatcactt tggttataga agaggcgttt cgcaaagctg 579181 gcatgacgta tagtgatatt gatgcgattg cagtaacaga aggtccggga ctggtgggag 579241 cgcttcttat cggagtgaat gccgctaaag cattgagctt tgcatataac attccgttag 579301 taggcgttca tcatatagcc ggtcatatat acgcgaaccg tcttgtagaa gacatcgtgt 579361 tcccggcact ggcattggtc gtttcaggag gccatacaga actggtttat atgaaggaac 579421 atggatcatt tgaagtcatt ggggaaaccc ttgatgatgc ggcaggagaa gcctacgaca 579481 aagtggcgcg gacgatggga ttgccatatc cgggtggacc gcaaattgac aagctagctg 579541 aaaaagggaa tgacaatatt ccgcttcctc gcgcatggct tgaagaaggc tcttacaact 579601 tcagctttag cggattgaag tctgcggtga tcaatacgct tcataatgca tcccaaaaag 579661 ggcaagagat tgctccggaa gatttgtctg ccagtttcca aaatagtgtg atcgatgtct 579721 tggtaaccaa aacggcgcgc gcggcaaagg aatatgatgt caaacaggtc cttttagccg 579781 gaggagtagc tgcaaacaga ggcctcagag ctgcattaga aaaggaattt gcccagcatg 579841 aagggattac gcttgtcatt cctccattag ctttatgcac ggataatgct gcgatgattg 579901 ctgctgctgg tacaattgct tttgaaaaag gaattcgcgg tgcatatgat atgaatggcc 579961 agcccggcct tgaattgact tcttatcaaa gtctcacgag ataatagcgt gagacttttt 580021 atctgtttgt tattaacaga caattcacaa tttatccaca tatctgtgag taattataga 580081 gatattgatg gataaagggc tgaggtcact gttaataaag tggataaatt cagaatattt 580141 tgtggatagt gtgtataaag cgcttacttt gtttatttat taggggatgt tctgtggata 580201 aaaagcacct ctaaaaagag gtgcttgact tttttaatct tcttctgtgg atagttcttc 580261 ccattcggac aaaagagatt ccagctcctg attaagcttc tcattgtctg catggatagc 580321 ttgtactttt tcatgatcct gatagacttc agggtcacat agcaattcat cattgcggct 580381 gatgttctcc tcaatggttt gaacggtggt ttcaatttct tcaatccgac ggagtcgttg 580441 gcgctctttc tttttccatt ctttttcttc ctcgtaggaa cgtttggagt cagacttcac 580501 tgtagctggc gttttatcag tttcctcttg ctgattcatt ttctccaatt caagctgctc 580561 tgtttttttc tctgtataat aatcgtaatc tcccagatac tcctctatat ggcttgaaga 580621 aagctccaat actcttgtgg cgattctgtt aataaaatat ctgtcatgtg agacaaataa 580681 cagtgtgcct ggataatcaa tcagcgcgtt ttcgagaact tctttgctgt ctaaatccag 580741 atggttcgtc ggttcatcaa ggatgagaaa gttggctttt tgaagcatca gcttagctag 580801 agccaatctt gctttttcgc ctccgctcag tgaatgaact ggtttcagca catcatctcc 580861 ggagaataag aaatttccga gacacgttct gatttctttt tctgggagcc cggggtactc 580921 gtcccacagc tcatcaagga cacgtttaga ggaagtcaac tcagcctgtt cctggtcata 580981 atagccgaca ctgacatttg agccgtaaga aattgttccc tgatctggtt ttagggtgtc 581041 tattaatgtt ttcagcaatg tcgatttacc tattccgtta gggccgacaa gcgcagcgct 581101 ttctcctctt gtgagcatga atgacacttc tgttaaaagc ggcggctggt tttcatagct 581161 gattgtgaga tcctgaacac gaaggacttc atttccgctc tgttttgtaa tatcaaaatg 581221 aaagtttgcg gatttttcat cgccaagcgg ttttgacatg acatccattc gctcaagctg 581281 ctttctgcgg ctttgcgccc ttttggtggt agaggctctc gccagatttc gatctacgaa 581341 gtcctgcagc tttgcaatct cgtcctgctg cttttcatac attttcagat ctttttcata 581401 ctgcgcggct ttttggtcga gataagcgct gtagttgccg tgatactttt tgctttctgc 581461 tcttgatacc tcgtatacct ggtttactac tttgtccaaa aagtagcggt catgcgaaac 581521 gatgagaatg gcgcctgaat agccttgtaa ataatgctca agccaggtaa gcgtatcaat 581581 atccagatgg tttgtcggct catcaagaat gagcaaatca ggctgtgtta atagaagctt 581641 acctaaagcc agtcttgttt tctggcctcc gctgaggctt tgaacctgtg tagaatcgtc 581701 aaaatggctg aagccgagac catgcagcac agatctaaca tccgcttcat attgataacc 581761 gcctttatct ttgaattcct gctgaagacg gtcgtaggtt ttcatgatgc tttctaattc 581821 acccgggtca gctgccgcca ttttttcttc catagcccgc atttcctttt ccattgcttt 581881 taagtggtca aaaacagtca gcagctcttc ttttatggta agcttagaat ccaagccagt 581941 atgctgggcg agatatccca ttgtaatatc tttcggttta ataatttcgc ccttttcata 582001 cgaaagctgg cctgcgataa ttttaaggag cgtggatttt ccggcgccat ttcttcctac 582061 aatggcgatg cgatcacgat ttctgacttc cagctttata ttgtttaaaa tagtatcagc 582121 accaaatgat ttggacagct gattaacttg taagatcatc atattatttc acctctgcta 582181 taataagtta agtgtagctt atgaaccaga agtcagcaaa caatacattg gccatataag 582241 acatagagaa gaaaatagtg tatgatctgt ttaaggagcg ttttaatatg aatggatttt 582301 ctcattttaa tgaacagggc agagcccaga tggtggatat tagcgaaaaa tcttcgactg 582361 tccgtactgc ggcggctgtt tcaagcgtac acatgaagaa tgaagtgtac gagaaaatac 582421 aaagtcacga tatcggcaaa ggagatgtac tggctgtcgc acaggtggca ggcattatgg 582481 ccgcaaagca aacgtcgaat atcattccga tgtgccatcc gctttcattg agcggggtag 582541 atatatcgtt tgactggaaa ataaaagaag cagaagttat acttcatata aaagcacagg 582601 tcaaaacgaa agggagtaca ggtgtggaaa tggaagcgct cacttctgca tcggtgtgcg 582661 ctcttaccgt ttacgatatg tgcaaggccc ttgataaggg aatggtcatc ggccctactt 582721 tcttgctgga gaagacaggc gggaaaaacg gtgactttaa aagagaacta tccgagtata 582781 atttggagga ccaaaaatga ataaggatca atcaaaaatt ccgcaggcga cggcgaaacg 582841 gctgccgctt tactatcgct ttttaaagaa tctgcatgcg tcaggaaaac agcgtgtatc 582901 atccgctgaa ctcagtgatg ccgtaaaggt tgattctgcc acgattcgga gggatttttc 582961 ctattttgga gctcttggca aaaaaggata cggatataat gtggattatt tgctgtcttt 583021 tttccggaaa acgcttgatc aggatgagat gacagacgtc atcttgattg gtgtcgggaa 583081 cttgggaacg gcatttcttc actataattt cacaaaaaac aataacacaa aaatttctat 583141 ggcttttgat ataaatgaga gtaaaatagg aactgaggta ggcggcgtgc ccgtctataa 583201 ccttgatgac cttgaacaac acgtaaaaga tgaatcagtt gccattctta cagtgccagc 583261 agttgccgct caatccatta cagacagatt ggtcgcatta ggaatcaagg gaatccttaa 583321 ttttacgccg gcccgtttga atgtgccgga acacattcga attcatcata tagatttagc 583381 agttgagctt cagtcactgg tttatttttt gaagcattat tcagttttag aggaaatcga 583441 atagagggaa aggaggagcc caaatatgcc gatcggtcct ggaagccttg ctgttatcgc 583501 aatcgttgct ctgattatct tcggtcccaa aaagctgcct gaattgggga aagcagcggg 583561 agacacactt cgtgaattta aaaacgctac taaaggatta acgagtgatg aagaggaaaa 583621 aaagaaagaa gatcagtaag ttaggatgac acgaatgaaa gtgaatcaaa tgtcgctgct 583681 ggagcatatt gctgagcttc gaaaacggtt gctgattgta gcgctggcgt ttgtcgtttt 583741 ctttattgct ggattttttt tagcaaagcc gattattgtg tatctgcaag aaacagatga 583801 agcgaagcag cttacgctta acgcgtttaa cctgacagac ccgctttatg tgtttatgca 583861 atttgcgttt atcatcggca tagtcttgac ctcgccggtt attctttatc agctttgggc 583921 ttttgtgagc ccgggcctct atgagaaaga gcgcaaagta acgctcagct acattccggt 583981 ctctattttg ctgtttttag cgggcttatc tttttcatat tatattttat ttccttttgt 584041 tgttgatttt atgaagcgga tttctcagga cttgaatgtc aatcaggtga tcggaattaa 584101 tgaatatttt cattttcttc tgcagctgac gattccgttt ggactgctgt tccaaatgcc 584161 ggtcatcctc atgtttttga caaggctcgg aattgtgaca ccgatgttct tggcgaaaat 584221 cagaaagtat gcgtatttta cgctgctggt gatcgcagcc ctgattacac cgcctgagct 584281 tctgtcccat atgatggtca cagtcccgct tttgatttta tatgaaatca gtatccttat 584341 atcgaaggcc gcttatcgga aagcacagaa aagcagtgct gccgatcggg acgtgtcttc 584401 tgggcaataa taaaaaatcc atttctcatg cgagaaatgg attttcttta tttttggttc 584461 tttttgattt taaatgaaaa ggcgaacatc ttaaaagaaa tgctgatgtt gtaagcggcg 584521 aacaccatca gcaggatgga gtaaaatgac cacatgctgc ctggcgagct tgcggcaaga 584581 taagtaaaga tgcaccctac ggcaaagtag atcattcccc aaactaccgg gtttctcata 584641 aaaataatcc tccaataatc aattgcattt gtgtgctctg ctgttcaagg taattacgaa 584701 caggctcaag ctgcatgatg acgacgaatg tattcatcat taaatgggcg aaaatcggca 584761 cccatatccg ttttgttctc gcatataaaa aggcaaaggt aaagcccatt gctgtatata 584821 gaaggagatg cttcaaatca gcgtgaacaa taccgaagat aaccgagctg atcagtcctg 584881 cgaaaaagaa attcgttttt tcgtacagcg cgccgaaaat gatttttctg aagatgattt 584941 cttctaatat aggcccgacg atggaagaaa cgataatcat gagcgggact gcctgaatga 585001 catccagaat cgcttgtgta ttttctgatt ctcttccgat gccaaaaaca taatattcaa 585061 tagagcctgc tattccttga gagaaaaggg caatgaaaaa accggctatc gcccaaagga 585121 tagaaagtcc gattgagtcc ttctgtccgt ttcgcagcgt ttctttcgga acggttctca 585181 gaatgagcag aacaacaacg agacaggcga taaagctgat aacggaccat aatccttgtg 585241 catgcagcat attttcatct gtaggctgtc ctccggcata accgaattta aataacaagg 585301 gaatcgcgat taatgcggaa aactgcatga tgatatatgt caaaataata aaccaatact 585361 gttttctcaa atggtatgta ctcctttgtt aagtgggttt cgttcatcta cagctattgt 585421 aacataatcg gtacgggggt gaaaaagcta acggaaaagg gagcggaaaa gaatgatgta 585481 agcgtgaaaa attttttatc ttatcacttg aaattggaag ggagattctt tattataaga 585541 attgtgttag cactctttag tgctgagtgc taaaattaca tattcatact attgaggagg 585601 ttatttcatt gttaaagcca ttaggtgatc gcgttgtcat tgaactcgta gaatctgaag 585661 aaaaaactgc cagcggaatt gtgttgccgg attctgcaaa agaaaaaccg caagaaggca 585721 aaatcgtggc agctggttca ggtcgcgtgt tagaaagcgg agagcgcgtt gctttagaag 585781 taaaagaggg cgaccgcatt atcttctcaa aatacgcagg tactgaagtg aaatacgaag 585841 gtactgaata cttaatctta cgtgaaagcg acattttagc tgttatcggc taattcttaa 585901 ataaacaata cttaaaacat ttgaggaggt cttgtaaaca tggcaaaaga aattaagttt 585961 agtgaagaag ctcgccgcgc aatgcttcgc ggtgtcgatg cacttgctga tgctgttaaa 586021 gtaactttag gaccaaaagg acgcaacgtg gttctagaga aaaaattcgg ttctccgtta 586081 atcacaaatg acggtgtaac aatcgctaaa gaaatcgagc tagaagacgc gtttgaaaac 586141 atgggtgcta agcttgttgc tgaagtagcc agcaaaacaa acgacgttgc cggtgacggt 586201 acaacaactg caacagttct tgcgcaagca atgatccgtg aaggccttaa aaacgtaaca 586261 gcaggcgcta accctgtagg cgtgcgtaaa gggatggaac aagctgtagc ggttgcgatc 586321 gaaaacttaa aagaaatttc taagccaatc gaaggcaaag agtctatcgc tcaggttgct 586381 gcgatctctg ctgctgatga ggaagtcgga agccttatcg ctgaagcaat ggagcgcgta 586441 ggaaacgacg gcgttatcac aatcgaagag tctaaaggct tcacaactga gcttgaagtt 586501 gttgaaggta tgcaattcga ccgcggatat gcgtctcctt acatggtaac tgactctgat 586561 aagatggaag cggttcttga caatccttac atcttaatca cagacaaaaa aatcacaaac 586621 attcaagaaa tccttcctgt gcttgagcag gttgttcagc aaggcaaacc attgcttctg 586681 atcgctgagg atgttgaagg cgaagcactt gctacacttg ttgtgaacaa acttcgcggc 586741 acattcaacg cagtggctgt taaagctcct ggtttcggtg atcgccgtaa agcaatgctt 586801 gaagacatcg ctgtccttac tggcggagaa gtcatcacag aagatcttgg ccttgacctg 586861 aaatctactc aaatcgctca attgggacgc gcttctaaag ttgtcgttac taaagaaaac 586921 acaacaatcg ttgaaggcgc tggcgaaaca gacaaaattt ctgcccgtgt gactcaaatc 586981 cgcgctcaag tggaagaaac aacttctgaa ttcgacagag aaaaattaca agagcgtctt 587041 gctaaacttg ctggcggcgt agctgtcatc aaagtcggcg ctgcgactga aactgagctg 587101 aaagagcgta aacttcgcat cgaagacgcc ttgaactcaa ctcgcgcagc tgttgaagaa 587161 ggcatcgtat ccggtggtgg tacagcgctt gtaaacgtat ataacaaagt cgctgcagtt 587221 gaagctgaag gcgatgctca aacaggtatc aacatcgtgc ttcgcgcgct tgaagagcca 587281 atccgtcaaa tcgcacacaa cgctggcctt gaaggatctg tcatcgttga gcgcctcaaa 587341 aacgaagaaa tcggcgtagg cttcaacgct gcaactggcg aatgggtaaa catgatcgaa 587401 aaaggtatcg ttgacccaac aaaagttaca cgctcagctc ttcaaaacgc tgcgtctgta 587461 gctgcaatgt tcttaacaac agaagctgtt gtcgctgaca agccagaaga aaacggtggc 587521 ggcgcaggaa tgcctgatat gggcggcatg ggcggtatgg gtggaatgat gtaataaagg 587581 gatattaacc cttatacatc aatgttttaa ccgtcttaaa aaactagaca aagcgtgaat 587641 aaaaaaagag aaggtctttc atcagtttac taaactgttg ggagaccttt tctccatatt 587701 agcggtcata tgagcataaa tgtccatcgt cgtatttatg tccgaatgac caaattgttg 587761 ctggatttct ttaatgccta ctcctgcctc aattagtaag gaggtatggg tatgcctaaa 587821 agagtggggg gtgacattct ttttatccca gcttttttga gcagccgttt aagtctagtc 587881 tcaataacct ttcttaattg cggatgacca tcctcccgct caaaaataaa tgatgagtct 587941 tgataaatca atctattttt aagcttaatt tcattttgat aaattttatt tttttttagt 588001 agattgacat cgtttcatca attcgaacga tatcaacaga tcctgttgtt ttaggtgtta 588061 gcaattggta tttttcaatt tgattgttag gggtgtatag ggtctttgtg acctggctta 588121 tcattgaaat ctgtccattt taaagcaaga agttcaccaa ttcttaggtc ggtctaggca 588181 agtacggtaa agaccaaatg gtccatttct agcccgtcag attgagcgag ctttagaaaa 588241 tgtgtcagca cctctttttc caatgctttg ttgcttcttg ggtaattgaa aatccccagt 588301 tgggttcatt ttaataatcc cttgagtttt agcttttcgg aaaatcatac ggccgcaggc 588361 atgaatacct cccaaacaat tgtgactgta ttgctcgttc agttctaacg tgcggtcttc 588421 atacattttt ttgtgttttg ctaatcgggt attgacccaa tactgcgata aaatgcatca 588481 ttttcttttc actggcccgt acactgctta tttttacccc actccggttg taaatcttaa 588541 gccaaccttt tgcaaatgtt ttgaagggca tatctgactc cttaataaaa gtcccgttgt 588601 cgttttggag ttctacgtga cgggctgcta ctggggcttc tttctttgtt ttaaatcttc 588661 ctttggatat ttctagacgt tttttggtta aagggtcaat gcctagtaga tatgataact 588721 ccacgtctta ccgcattgct tgagttttgc catttatttg tccctaacta attttttttc 588781 atcaaattgg tctttaagtg agtttaataa tttttgtttc tctcgactgg tcaataattg 588841 cccttcatat ttcaaaagat tggataaatt tgagatggaa tcaatcctga tggatggtac 588901 cgtagacttt aataagaaac gaaaggccaa ctgcgacttc agttggcctt tcctatttat 588961 aataaagaaa ttgagtgaga ttgctgacag aactacgtac tactcgtttt ctttagttgc 589021 ccttgctaat cgttcaacct ctccccgaat cccaatcgca ggctcccacg aatcaatcaa 589081 acgaatcgcc ttctgattag attccaccgc tttcgttttc tctcctttac gatacaacag 589141 ctgcgccatt ccgtagtgat agtagatcag ttcaacttga ttggcgttat gtttgtcata 589201 gagcatttgc tcaaaggctt cttccgcttt ttcaaactga tcacatttca cgtaagcgac 589261 acccagattg aaataggctt ctatcgtttt ttcgccgccg tatgtggagc tgatttcatt 589321 tgccgcttcg tataattgaa tggcttctac atgataacct ctcgcaaagc ttaagtcacc 589381 gcgaaccaat agaactctgt gttgaatggt aggggaaatc ggttgatttt cgatttcgtt 589441 taaaattgtc tctgcttttt cctgttgccc gtcttttaaa aacagccttg ctttgagtgc 589501 atgtccccaa acctttagat cataggcatc gtgagcgtct gattgttcaa gaatcttcag 589561 cccggcttct atttgctgaa gcgctccgtc taaatcattg acttccatca atgcccagcc 589621 tgaggtgtcg attcggaagt acgcttctcg tgtgtgttgg cctaagtgat gggcggcgtc 589681 ggccgctttg cgtccgtatt cgattcgcag gggcaggttg attctgctta gaaaatggct 589741 aatgcgggtg atgagttcga ttaggatttc tttttgttca gtttcacttg cccattggat 589801 gacctttaag atgtttggcc attcttgttt catttgatct aagttccgtc ccagcaggta 589861 gctccaatag atagagttgg gctgttcccg ctttaaatgg gtttcggcat aatcaatata 589921 atagtgcgcc cagcgattgc gggcttcttt ttcatattcg tgctgttcgg acaagtgctg 589981 ttctccgtaa gcgacaacgg tttggtgcgc taagtattgt gtcctgcctt ggcttcgttc 590041 cggctgaatc agcgcatatg accgcatttg ttccatagcg taatgaaaac ggcgggcgtc 590101 taatccggct gctgccgcca ggcttttttc atcaggcggc ttgctgaaaa agcaaagcgt 590161 ctgccagagc tttcgcgtat cttcattgca tctatcccag gtgcggccaa agaggaattc 590221 aaacaattcc agcagtgagt agcctgcttt tccaagctca tgaatcagct gctgagcggg 590281 gatgtcatcg tctgacatat aggcaatgct gagtgccatg gctttcgggt ttccggcagt 590341 cgctgaaatg aattcgtttt tcaggtcaga tgatagatgt aacagctgct ccagcttttc 590401 ccgtttacgt gggaggttgc atgtttgtaa gcagtgatgc acttcttgtt gaaaaaattc 590461 gtgggcatct gtttggtcaa gaccgcttag ctgaatggct gtcatttctc cgaagctttc 590521 ccgataagtt tgctttacgt tttcccgcgc tgtaaggaga acttttacgc cttgcggaag 590581 gctggtgata aattcatgaa tgtcacgttc tgcagtatca atgctgtcaa cgatcagcag 590641 gatcggtttt tctctagtgt aattggctaa cgcattgcgg acgacaaacc gttttacatt 590701 gattgattta tcgatttgtt ctttgcgtcc gagctgatag gcgatcgtat ttaaaaaatc 590761 gctaaagctt aatcctttcc aatcagcgct gacccagatg atgctgttga atgccggcca 590821 aactgaagta tcgtcgacac aggaataggc ggcttcaaga gcaattgtgg tttttcccat 590881 gccggcccag ccggtgatta aacagactgg tgatggagaa agcatccatt gccgtatcgc 590941 ttccatatca aagctgcgtc cgataaagcg tccggaccag cgtgagggta aattatgcgt 591001 gatgggctgt tctgtaagcg cattcgtttc ttggccgggt ctgtcatgaa acagccgttt 591061 tactacattt tcaatttcgc cttcactcgg agccccgaat aatccgtctt ttcgcagtat 591121 tttcgctttt ttcaaacagg atgctgccca tacaggcaat gcgggtttga tgactgggat 591181 agtggtggct tccagcaagt cggtcaacca ctcgatatcc aagtcggtct tttcgagaat 591241 gatccagatc attccgaaca gttttccgtc gtcgattctt ccgggaatgt agtttgcccc 591301 catctgtccg atccagcttt tgatcgtgtt tggggagact cccagctgga gtgcgatttt 591361 atctatgtaa gactgtcctg ttttttcatt ctttttcctt ctgactttat aatcaggatg 591421 aagttttagc gttttgacgc caggtgccag catttgtgca aattgttttc ggttttcaag 591481 ttcagccata agcctgcacc tcctattagt actattttat caatccagcg ttttttgtat 591541 atgaaaaaat aaaagtacag tgccgctgtc cttttataca gcaggaaagg ctgttgaacg 591601 tgttaaaaag cagataaaat gggggcagta acagagaaaa caaaaatgta tgcacttaca 591661 ttttattttc taaagaaagg aacttgccaa atgactcaca cagtacctca aaacatgaaa 591721 gcggctgtta tgcacaacac aagagagatc aaaattgaaa cattgcctgt gcctgatatc 591781 aatcatgatg aagtgttgat taaggtgatg gctgtcggaa tttgcggatc tgatctgcat 591841 tactatacaa atggccgaat aggcaactat gttgtggaaa aaccatttat ccttgggcat 591901 gaatgtgcgg gtgaaattgc cgctgtcgga tcatctgtcg atcaattcaa ggtgggagac 591961 cgcgtcgctg tagagccggg tgttacgtgc ggacgctgtg aggcgtgcaa agaaggacgc 592021 tataatcttt gcccggatgt acagtttttg gctacaccgc cggtagacgg tgcgtttgtc 592081 caatatatta aaatgcgtca ggactttgtt tttttaatcc cagactcact ttcttatgaa 592141 gaagctgctt tgatcgagcc gttttctgtc ggtatccatg cggcggccag aacgaagcta 592201 cagcccggat caacgattgc gattatgggg atgggccctg ttgggttaat ggctgttgcc 592261 gcagctaaag catttggggc aggcacaatc attgtcaccg acttagagcc gctgcggtta 592321 gaagctgcga aaaaaatggg agcgactcac attattaata tacgtgaaca ggatgcactt 592381 gaagagatta aaacgatcac gaatgataga ggcgttgatg ttgcttggga aacagcaggg 592441 aatccagcgg cattgcaatc cgcactggct tctgtgcgcc ggggcggaaa attggcgatt 592501 gtcggtttgc cttcacagaa cgagattccg ctcaacgtgc cgtttattgc ggataatgag 592561 attgatattt acgggatctt ccgttatgcc aatacgtatc caaagggaat cgaatttctt 592621 gcttcaggca ttgtggacac gaagcatcta gtaacggacc aatattcgct ggagcagacg 592681 caagatgcga tggagcgggc gcttcaattt aagaatgaat gtttaaaagt gatggtgtat 592741 ccaaatcgct gagtgaacag ggaggatctt cgtattctcc ctcttgttta ctggaaatga 592801 aaacggattc ttggggtggg aaatgatgat tggaacagaa aaagtaacgg cattgaaggc 592861 gaagcatcag tcaaaatcca gcaccggcct gtcctggttt gaacgaatcg gttatggatt 592921 cggcgatatg tcgtataata ttatctttca gtttgtaaac gcatacttat tattttatta 592981 tacagacgtc ggcggcattc agcctgcggt aatcgcaact ttgtttcttg ttgtgcgtgt 593041 gctggatgct atttttgacc cgatcatggg attgatttta gataaaacga atacaaggtg 593101 gggaaaagca aggccatatt tgctgtgggt ggcatttcct tttgcgctat tcacattctt 593161 atgtttcacg acgcctcatt tcggtgagac cggaaatatg gtatatgcgt atgtcactta 593221 tattctgctt gggatgtcct ttagtatgca aacgatcccg gtgaacagct taacggggcg 593281 gatgacgaat tcggtggagg aacgaacggt tctgaccaca acccggatga ttttggtgta 593341 tatcggcatt cttttatcca tttcctgtgc gacaccgctt gcaactgcta tcggaggaga 593401 ggatcaggcg tttggatttc agatgacggc gctcatctat gcggctgtca gcatcgtttt 593461 gaatctattt agtttcttta ctgtacggga gcggattcag cctaaaaaga gaaaaaaaca 593521 agggatcaaa aagacgttat ccgttttatt caaaaacaaa cccttgctca tgttaatttc 593581 atcatttttg gcttttgcga tcgggtttaa tattaagctc agcacgatgg tgtattattt 593641 tacgtataac gtaaaccata aagagttcgt gtttatgggc accgttttat ttttcggggc 593701 agcgctgatc agcaatttgt ttattccttt cttttctgag aagtggggca gaaaacaagt 593761 catgattatc acggcagctc tatcgcttat ttcttatgcc ggcctgcatt ttacgccgta 593821 ttcttcaatt ccactcattt tcatttggct tttcgcttcg ggatttttca caacgccttt 593881 aaatacgctt gcttggggaa tggttgcgga ttgcgtcgat tatgcggaat ggaaaaccgg 593941 aattcgcgcg gatggtgttg tgatttcgag catgagcttt attaataagc tgggtgttgc 594001 gttagccggg tcattttcgg ccatttattt aggaatcgcc gggtatgtgg cgaatacaga 594061 ccagacagtt gcgtcgttga atgcgattaa aaatatgaat gctttgattc cgggattttt 594121 cattttgctt tctattattc ttatcgcctt ctatccttta acggaaaaaa gatataaaca 594181 catcatctct gagctggagc aaaggtctgc gagataaata gatgtaaaat ttttaatatt 594241 caatgttgta tttatggcaa aaagtaatat actgagactg taatctagac tttataaatg 594301 agtgtgataa tatgcgtagt cattctgtag tttgtattgg ggaattgttg attgatttct 594361 tttgtaccga tgttgacgtt gatttaatgg aagggcgcca attcctgaaa agtgccggcg 594421 gggcaccggc gaatgtgtcg gcagcgattg ccaagctggg cggagacgcc gctttcagcg 594481 gaaaagtagg aaaggatccg tttgggtatt ttctgaagcg aacattggac gctgtacatg 594541 tcgatacctc tatgctggtg atggatgaga aagcgcctac aacgcttgct tttgtttcat 594601 taaaacaaaa tggagagcgt gactttgttt ttaatagagg cgcggacgct ttgtttacgc 594661 tggaggacat tgaccaggaa aaactaaacg aagcgaaaat ccttcatttc ggctctgcga 594721 cggcactgtt atcggatccg ttttgctcag cctatttacg gttgatgtcg attgcgaaag 594781 acaatggaca gtttatttcg tttgacccta actaccgtga agatttatgg aggggaagag 594841 tctcagagtt tgtaagtgtt gcgaaaaaag cgatcgctgt aagtgatttt gtgaaagtca 594901 gtgacgagga acttgagatt atcagcggtg tgaaggatca tgaaaaggga gttgcgatcc 594961 ttcatgagat cggagccaac attgtcgctg tgacacttgg gaaaagcgga acgcttcttt 595021 ccaatggaaa agaccgtgaa atcattccaa gcattccggt gacatcaatt gactcaacag 595081 gggcgggaga tgcttttgtc ggtgcggctt tatatcaatt ggcaaacacg gatcagattc 595141 aatctgtaga tgctgatttt gtgaaactgc gtgagattgt ggcgtttgcc aataaggtcg 595201 gagctcttgt gtgcactaaa attggagcga ttgatgcact gccgagtttg gatgagattg 595261 gagtttcttt gtaaatcatt gaagatgttt cttgaaagtc tttggacttt tgggggcatc 595321 tttttttatt gcttacattt ttgttcaggt aaaaagttgt atattttttg tttgaaatgt 595381 cattttttat taaaaaagtg aaacttttaa cgataataaa tagtatatgt aacaagggtt 595441 accgaattag ctttaggagg aacgatataa tgagtataat tggaagattt aaagatatta 595501 tgtctgcgaa tatcaatgct ttattggaca aggctgaaaa tccggagaaa atggtagatc 595561 aatatttaag aaatatgaat agcgatttgg ctaaggttaa ggcagaaaca gcagctgtta 595621 tggctgagga gcagagagca aaaagagaat atcacgaatg ccaggcggat atggaaaaga 595681 tggaaagcta tgcaatgaag gcgctgcaag ccgggaatga gagcgatgcg agaaaatttc 595741 ttgaaagaaa aacatctttg gagtcaaagc tttctgagct gcaggcggcg aatcaaattg 595801 ctgcaaccaa tgccgcacag atgagaaaga tgcatgacaa attggtatct gacattggag 595861 agctggaagc acgcaaaaat atgatcaagg cgaagtgggc agtagcgaaa acgcaagaaa 595921 gaatgaacaa actgggcgct tctgtttcaa gtacaagcca atcaatgtct gcattcggcc 595981 gaatggagga caaagtaaat aaggcacttg atcaggccaa tgcaatggct gaactgaaca 596041 gcgctccgca ggatgatatg gctgatctgt ctgcaaagta tgacactggc ggttcaagcc 596101 aggttgatga tgaacttgcg gcgttaaaag cgaaaatgat gctcgataag taatacatag 596161 gaggccgcag ctttcggctg cggcgtcatt ttatcataaa atgtgagagg gaacggtaat 596221 gataatatct tataagtgtc cgaactgcgg cagtgatatg gcatttgaca gtgaaaccgg 596281 ctcgttatcc tgcagcagct gcggaagaca ggacaatatt gaaagccttc cgaaagaaaa 596341 cattgcggca cggttttctg atgatgaagc aaaagaatat caatgtaaaa actgcggtgc 596401 cgttttgatc acggaagctg aaacgacagc aacgacgtgc agcttctgcg gaggtgctgc 596461 aatacttgcc gatcgtttat caggacattt ggcgccggcg aaggtcattc catttacaat 596521 cagcaagcaa gaagcggagc aggcatttcg aaagtggtgc aaaaaaggcc ttctgacacc 596581 aagaggtttc atgtctgctg atcgtatcaa aagcatcacc ggcatgtata ttccattttg 596641 gatgtttgat ttaaatagtg aagtacaggt gagagcaaac tgtaccagag tccatcaata 596701 tgaagaaggg gattatattt gcacggaaac agagcacttt gaagcgtttc gtgatatcaa 596761 tctcgattat ttgaaaatcc ctgtcgatgc ctctgaaaaa atgaaagacg aattaatgga 596821 caaattggag ccttattcat acgaagagct gaaggacttt caaacggcat atttggccgg 596881 ttatattgcg gaaaagtaca attataccga tgaggagctt tttccgaggg caaaagagaa 596941 aatcagcagt tatatagatt catacatcca ttctactttt tccggatata cgtcagtcaa 597001 tgtgagggac aaacatattc acacgaaaaa cgtgaacagc ttttacgttt tgcttcctgt 597061 ttggatggtc agttacgatt atgaaagagc ggagcatatc tttgcgatga acgggcaaac 597121 aggaaaggtc gttggaaagc cgccgatcag tcgaggaaaa gtggctgcat ggtttagcgg 597181 aatagcaggc gggacatttc ttgcgttgaa gctcgtctca ttgatgatgg gaggcggatt 597241 ttgatgcgtg gattttttgg gaaagcgatc tttgttgtgc tggctgtttt catcatgatg 597301 cctttactgg gtatcgaagc ggtaagagcc tctgaattgc agcagcatgt gtacgatcgc 597361 gctcatctat tgtcaaaagc ggagatcgga aaacttgaat ctctctcggc aaagctgggt 597421 gcaaagaggg acactgattt catcattatt acgaccaaaa gcacaaacgg tgaagatatt 597481 gcagactata ccggcgattt ttatgatcgt tacggaaaag gcagtacagc cattctgacg 597541 attgatatga caaacagaga agtgtttatc gcaggcttta aaaaagccga acagtatttg 597601 gacaacagca ggctcaatag catcagaaat acgatttcat ctgatttatc caatgaaaat 597661 tattttgaag cttttgagac atatattcag ctttcctata aagatatggg cataaaaccg 597721 ggagtaaacc ctgacaacat attctttaca tggtggtttc agctgattgc tgccatcgca 597781 gtcgggggaa ttgcggtttc aatcatgctt tatcatgcag gcggcaaagt aacggttaat 597841 ggaagtacat atatggatca gcgtacgtct gatgtgattg atcaatacga cacttatatt 597901 agaacgactg taacaagaga aagaaaacca tcagataaag acagcggcag cgatggcggt 597961 gttacgaaag gcggcacgtc atacagtggg agccggggca gtttttaaat gtaagaaata 598021 gagaaaggga gaggcgtaat gtcgtttttc agaaatcaat tagcgaatgt agtagagtgg 598081 gaagaattta gagatgatat gattttttat aaatggaaca atcgtgaaat caaaaaaggg 598141 agccgtttaa tcattcgtcc cggacaggat gctgtctttt tgaacaatgg gcgggttgaa 598201 ggagtctttc aagatgatgg cgattatgat attgaatcag aaattattcc attcctttca 598261 acgttaaagg gctttaagtt tggctttaac agcggcatgc gagctgaggt gctgtttgtc 598321 aatacgaagg aatttaccgt aagatgggga acaaaacagg cgataaatat tccggcagcg 598381 ggaatgccag gcgggatgcc cattcgcgca aacggcacat ttaatttcaa ggtgcaggac 598441 tatatcagcc tgattgataa aatcgctggc gtgaaagatc aatattttgt agaggatatt 598501 aaaacccgta tcatttctat tctggatcag cttctcatga agtggatcac aagagaaggg 598561 aaagatatgt ttaatcttca agcaaacgct tttgatattg ccaagggaat tcaagaggac 598621 ttagatatgc aattaataag cgacgggatg acggtcactg gttttcaaat catgagcttt 598681 aattatcctc aagaggttca agatatgatt acaaagaacg cttcctacgg tatggttggg 598741 gatgtgaaca gataccagca aatatcaatg acggatggaa tggcatccgg aaagatgagc 598801 ggaagcggag cggcttcgga tatggctgga atgatgatgg gaatgaatat ggccaatcag 598861 atgatgaacc aaatgaatca gaatcagcag gcacagtcat caggcccaca gtcaactggc 598921 agcggaagca aaccgaattt ctgtccaaac tgcggaacaa aaacgggcga agccaatttt 598981 tgtccgaatt gcggccagaa gcttgtataa gaatcataca gtgaaaagtc cggagtgatc 599041 agcactcggg acttttttat ttaggagaat aagcattacc tattgcttgc tcctgaacag 599101 gccattttcg agcccccgct tggataattc ccagcagcaa ttgacgacgt tcctttattg 599161 aattgacggc aatttgaaat gtttgctttg ataaagccgg tatgcctgat tgttgaagct 599221 ttgagatgtc tggttctggc ggcgcttgtt ctgcaggatg gatataggca gtatgaacgg 599281 tatccagata gtttttgata cttgagcgcg cttctttgat atgaagctga ttcggctgat 599341 attgttcagg aattccgtat ttgaaaatgg ttagagcctc atccaataca gcaacagcta 599401 taatggatga ttcctgatgc tgcgtgctgt ggtaaaaatg aaggatgggg aaggcgttat 599461 gctgagcggt cagctttccc agttctgatg aggcagcgac aagaagaaaa tcaatgtcgt 599521 gaaaatcttt gccattccat gcattatgga cgatttcagt tccgtcatgc cctagactta 599581 atacactttg ggcaaaggag cgtttttgat taaccgcact caagacggaa atcaaatacg 599641 tgacagaaaa tgtgatggta agcagtcctt gagctgtttc aataatcgtg acaagcttcc 599701 ataggcctcc gttcggagcg aggtcgccat ttcctaatgt aaacatgaca tagccggaaa 599761 aataaattcg gtctgaccag gaagccggtt cttttgattg agtttccata agtgagtgag 599821 ggtcactcga gtaaatcaaa acccacccgc tccaaaatag actgatccat atcactaacg 599881 tcaggcataa cagcagagga ccagccatac ttagaacctt tgcgtggtca ccgctgattt 599941 tgcggcagcc cttccacagc caggcagaca ggcatcttgt gatcgggccg gcaccgctct 600001 ctaaccataa cgtggtccat aaaaaatcaa tcatccccgc tgtcaataat aaaaggcctg 600061 caatgatata accctcattc attttggttg cctcccttaa gtcagccttc ttttattttc 600121 ttctctattt ccttttatcc tgagtctgaa acaattgaac gaatgtttga ttttacagag 600181 aaaaataggt gggagttacc caacacttac tcatttttca atatgaacag aaaatcacaa 600241 gatttttgac ttgattcaca cattttcatg aagaaaaacg ttcattttcc ccttgaattg 600301 gtgattttcc ttttatagag taaaaaattt tcagaaattt atattgactg aaagcgtttt 600361 tataattatg ataatatcag atataacaaa aatgtcacta taacatcact acaattgaac 600421 tattaagtga ctaataaata ccaaatgaac gaggttatgc acaaagaaat gaccattgtt 600481 cttttaacga gaaatgaaat cgcttccata gggattgaca tgctaagaag aagggaaggt 600541 tatgaggtta ttggataaaa acatgaacaa ctattttctg aagcctgctt acgaaatgtg 600601 aggaaggcag cagccctgga ataagttttt gacatacgca ttttgaaaaa gactggggga 600661 aacagtatga ataaacaagg aaatcaaatg tcatttttac gtacaattat tttagtctcc 600721 actttcggcg ggcttctttt tggctatgat accggtgtgc tcaatggagc tttgccgtat 600781 atgggagagc cggatcagct taatctcaat gccttcacag aaggccttgt caccagttca 600841 cttctttttg gagcggcact gggtgctgtg tttggcggca ggatgtctga ttttaacggc 600901 cgccgcaaaa atattttgtt cctcgctgtt atatttttta tttcaacgat tgggtgtacg 600961 tttgcaccaa atgttacggt catgattatt tcccgttttg tgctcggtat tgcggttggg 601021 ggtgcatccg taacggtgcc tgcctattta gcagagatgt ctcctgtgga aagcagggga 601081 cggatggtga cgcagaacga attgatgatt gtatcaggac agcttttggc ctttgttttt 601141 aatgcgatcc ttggaacaac aatgggagac aactcccatg tgtggaggtt tatgctggtc 601201 attgcgtcac ttccagcctt gttcctgttt ttcggcatga tcagaatgcc cgagagtccc 601261 cgttggcttg tttctaaagg aagaaaagaa gatgctttgc gtgtattgaa aaaaatcagg 601321 gacgaaaaac gggcagcagc tgagctgcaa gaaattgaat tcgctttcaa aaaagaagac 601381 cagcttgaaa aagcgacatt taaagatctt tcagtcccat gggtgcgccg tattgtgttt 601441 attggattag ggattgcgat tgtacagcaa attacaggtg tgaattcgat tatgtattat 601501 gggactgaaa ttctaagaaa ttccggtttc caaacggaag ccgctttaat cggaaatatt 601561 gcgaatggcg tgatttcggt attggcaaca ttcgtcggaa tctggctgct gggaagagtg 601621 gggcgccggc cgatgctgat gacaggcttg atcggtacga caacagcatt attgctaatc 601681 gggatattct cacttgtact tgaaggatca ccggcacttc cgtatgtagt cctgtcatta 601741 acggtcacat ttcttgcttt tcagcagggc gccatttcac cagtgacttg gctgatgcta 601801 tctgaaattt tcccgcttcg ccttcgcgga ctgggaatgg gtgttacggt attctgtctg 601861 tggatggtga attttgcagt cagtttcacg tttccgatat tgctggcagc tatcgggctg 601921 tccacaacgt tctttatctt cgttggatta ggaatttgct ctgtcttgtt tgtgaagagg 601981 tttttgccgg aaacgaaagg gctttcgctt gagcagctgg aggaaaactt ccgcgcttat 602041 gatcacagcg gggcaaagaa ggattctggg gctgaagtga ttggataatt taaaaaagaa 602101 tccgcacccg agtgcggatt ctttttggtt tcaaattagt taggtctaac aaggattttg 602161 acttggcttt tctctttaat aagagccccg aagccttcct cgatcaaatc atctagtacg 602221 atttttttcg ttacgagttt gtcggctgag aaatagcctt ctttcattaa tgacaataca 602281 gccgggaaga tgtcgcggta tccgataatt ccttttactg tacgttcttt gattacgata 602341 tcgttcggat ggatttcagc acctttttcc caaatgctga cgatgacggt ttcaccggca 602401 attgtagtgg actggatggc ttgtcgtaac accactggga caccagtgac ttcgaatgct 602461 acgtcaacac cgcctcctgt acgttctgca atctcagcga ctacatcgtc tgttttagac 602521 ggatcaacga tgatcgcgcc aagctcctca gctttttgct ggcgttcagg agaaagctca 602581 acagcgtaaa tatcagttgc accggcagcc ttcagcgctt caatgacaag aagtccgatc 602641 gggccgcagc cgaatacagc cgctttgtcg cctgctttga gtttgcttga gcggacagcg 602701 tatagagcaa ctgcagaagg ttcaacgagc gcgccttgtt catatgataa ttcatcagga 602761 agtttgaaca aaagctcttc atccacagag acgtattcag agaaaccgcc gcctccgccg 602821 gctaagccga ggaatcccat ttgttcatca aggttgtagg cgccttggtg gccgtgtgta 602881 gcaaaaatcg gctcgactac aacgcggtct ccaactttat aattttcaac gccttctccg 602941 acttcgacaa cttcaccgga gaattcatgc cccattgtga caggtgccgt ttcatttgtt 603001 aatgggtgcg gtttgtcaac cggaataaag atcgggccgc ccagatattc gtgtaaatca 603061 cttccgcaga tgccgcacca tttgactttg atctttactt ttcccggctc cgtttttggc 603121 tcttcgatat gttcaatacg gatatccttt tggttatgcc atcttgctgc cttcatggat 603181 taccactcct ataacttttg atgtgagtaa ttccgcaccg gtcaatatga actgttcaca 603241 aaatcgccat ttttaaaacc aaaaaagaaa tgaaattttt atataatata atctacgttt 603301 ttttgaaaaa aagaaacttt aaagaaaaaa gggtctcgca cactcttttt tctttatatg 603361 agagtatcaa tcgtttacat agctatgaat ttggtttgaa caatacggta atggttcgtt 603421 catattgaat gcgacaacta ctctatcaat aattataact ctaatactgc tattataata 603481 ggataatctt ccatggttta ttttagcaga ggtaactttt ttgactttgt aacattactg 603541 taaggatatt gaaataaaaa atagctggtt gatcgtgtat aatcttccta gatgttaaca 603601 aacaggggga cgaaatgttg aagaaagtca ttttagccgc ttttatctta gtaggaagta 603661 ctttgggagc ttttagtttt tcatcagatg ccagtgcgaa acatgtgaac ggaaatatta 603721 cttggtataa tggagtcggg aaaaaaggct cttcaggtaa gaaacttgga cattgggatt 603781 gtgcgaccaa aatcggattt gatgttccta gaaacgggac aaaaatcaga gcttatgcaa 603841 aagcgaagcc taaaaaggtg attacggttt ataaaaatga tgttggcaga atgcctaatg 603901 cagtgctgga tgttagccct aaagcgttta aagcgcttgg atacccatta agcaaaggta 603961 aagtagcggg gcattacagc tattaatgta catatataat ctggaaagca agaagtcaca 604021 ttcttgcttt ttctattggt ggagataaaa gatgaaaaaa agaatcatat tattattagc 604081 agtgataata gcggcagctg ccgcgggggt tgcgttttat gttgcaaagg ataaaggcca 604141 tgagaaggct gctgatgttt cagtcaatac cgaaagcggt gatgagctgc tggtttcaat 604201 tacagatacg gatctgctga caaagtatta tgaaaatgac aaggtgatcc atgaggagaa 604261 gctgaccagc tatccggcat ttgccttgga tcaaaaacag caggtgctct attatacggg 604321 caataatgaa cagaatgaaa tgaggctttt taaattggat ctgaagtctc ataaaaaaac 604381 gatgctttat aaaggcgcgg agagtgcgga cagtttattt ttatcaaagg accgttcaac 604441 catctatttc cgcttaggaa aagcggacga aagcaatttt cgaatcgccg cttttgatct 604501 gaagacgaaa aagtataaaa atctttatcc tgccgctaat gatcaggatg acaccgtcag 604561 cagcttcttt tataaccaaa aaaacgattc atttgcattg cttcattatt ctgtagaaga 604621 agactacaag aaaacagatg aagcaaacga aaagggcatc gaccctgaac cgacaacgat 604681 tcattttgcg gaaggccgcc aaaataaatt taatgagctg aaaagcctga accaatttat 604741 cagcgatatt gctgtttctg atgatgataa acgtatttta ttcacatcat atacgcaaaa 604801 aggaacggag caaaccgctt ctattcaaat gctcaatgcg gatacgaaaa aatatgaaag 604861 catcatctca aatcaaaaat catttaagct gttaattgac gcacagcctc agttttctaa 604921 ggatgggaag aacatttatt ttcttgccga agccaagggg gctaaaaagc tgaaggacga 604981 aacagggcgt gaagctaagg tgcggacgat ttattcctat agccttgaga ataagacctt 605041 caaaaaagta tgggaaaatc cgaacggcat catcaacagc ttttttgtga ttaactaata 605101 aaaaccactc ggcatgagct gagtggcttt tttaatggat gaggtgcagg gctaatgatc 605161 cgagccattt aaagatatga atcagaggta ccgacaaaaa cagaagttca acatatgagt 605221 tcattgcaac attcagcttt ttgaacgcag ctcttttttt caagtctttt tgctgctggt 605281 ttgagatcac gttatcactc ctcttatatc catattatac cattaaaaca gacaaaaaag 605341 ccctaaacgt ttacagtttt gggcttcttt cttcgtattt ggcctcttgc aatgagaggc 605401 ttttattctg aaatatagaa ttttgtctcc gttcggggtt tgtttgcttg cgggagactg 605461 catttgttat agggaagaac tagcttgttt tcgtttggct gttgttttgg agattcacta 605521 atgaacggat gccgtcgacc attttacttc cgcacaaagg gcacaatggc gtatcactgc 605581 tggcgaagtt ttttcgggtc cagccattac agtcttcttt tgtgcattcc caagtactca 605641 catcttcctt tggcagcggt tcttgatttc gtttgttata gtaagacata aagtcacttc 605701 ttccctcatg tattttactg cacatttcct attgtctcat acttttccct aatctcctaa 605761 ttcctttttc tttatgactt tccaataacc ccatctaaaa aggagaggag tgtgctgtta 605821 aaagcatctg gctcttctaa aaacgggcaa tggctgcttt taggaaaggt aacgagtgtc 605881 gcgtttggaa tattgctgcg caagtgttcc ccagctgctg tagagaaaaa tttcttgtct 605941 tccccgaagc acagcaatgc cggcacattg atgttttgga gggtgccccg gtaatcagcg 606001 gccgtttggt taaataaaat cgtgctagaa atggcagccg gctgtttgag gatttctgcc 606061 agcatccatt ctgtttcggt ctcggcaggc ggttctgcga acatattctg gatgaagctt 606121 tcgtagaaag gcagcgggtc agtttgaatg gcgtgcatcg ctgtttttaa gccgtcaaaa 606181 tcaaatggac catgttccca gccctcccat tgatagtccg aagcggattg atcgatgatc 606241 acagcggctt gaatgttatc attcccaaac tgattgagat aatcccatac gacaaaagca 606301 cccattgacc agccggcaag aacgacatga tcaagctcca ttgcatttag aaattccctt 606361 atgtcacggg catattggga aatggtgtgg ccgtgaagca ctttgtcaga ttcgccgtgt 606421 cctctaagat caagacgaat acattgataa ttggcagaaa gcaccgaaaa ttgtttgtgg 606481 aaaaattgtc cgctcatcag caccccatgt ataaacagga tcggcgtccc gctcccgtgt 606541 gtttcatagt aaaggcgtgt ctgatcttct aatatgatgt atggcatgtt tctcctcctt 606601 tagtttccat catgagtatg gctggctgct gttgagctga tgatggcagc tgtcgcggct 606661 gcctgctgcg cttgaatgac tgtttcgata gcggtgtata gtcctgattc catcagcaga 606721 tttttctcca tatgctcact gagatagagg ctgacagcaa ttttaaagtt catttccttt 606781 tgccatttaa aagctttttc ctggtttaat tcgtcagtga tgcacaaaac ggttttgata 606841 tctggctctt ccagaaatgt gaggagagca aggtctggat aatgataatc ctttgttttt 606901 ttgacagatt cagtgatcga ttgatatatc tgtttgcaag cggaaacaag catttcgggc 606961 tctttttcac tttgcaaggc cagaatatgg ctgacctgat gtaagtactg tcctttttta 607021 aagccgttgg ctgccagcag ttgatagcat gtttccgcct tctgtagcgc ctgcaaacct 607081 tttccgtttt ctccaagcag tacggcaagc ggaacattct gagttgaagt gaggaaataa 607141 tgatttttct tcatctgctg ataaacagct agccccatgt tcatctgttc tttttggttt 607201 gtcgtttcag atttgccggt gagcaagatc agagcggaaa ggtatgtgaa catatcccgc 607261 ttatacccta gcttcaccat ttcattgtat acatcgatga aagtctgaaa tgtttgtttt 607321 gcctcatgct gaaaatgaat gtccagaata gatgcaacag taaagcggtg gtgtgaattg 607381 agtgttgaga agctgccgat gtttgatttg atatagctgc tcaaatcata aaagcgctga 607441 aaatcaaact ctcttttatt cacaatatat gcagaagaaa tgagcattaa tatctgatcg 607501 tgtgaaactt tccattttaa ttttgttttt aattcagcat aaatggaaat gtaatgcttt 607561 gttttttcat gtagatcgtg tgtgagcata aaaagcagct ccttttgttg tttttacgta 607621 atacgataaa tagggccaaa ggtttcataa agaaaaaact tgcctgctag aggcaagttt 607681 gtcgggttat ttatggggat cagttatatc catcggtctc atcatgtcat agtcttcatg 607741 ctctagaata tggcaatgcc atacgtatcg tccgctgtac ggaccgaatg tcgccgcgat 607801 tctcaggact tcacctgcat gcgcttgaat ggtgtctttc cagccctttt cacttggcgg 607861 cggcgggaca gccggaccgg tataggacaa ttccccgctt tcttgataac gggcgatatc 607921 aaacggccgc cggtctaata cacggaagga gactagatgc aggtggatcg gatgtgttcc 607981 gcgtgtcggg ttgataatgg accatatttc agttgtgccg acttttggtg tttctgtgac 608041 gggatcgtgc cagcgtttgt tattaagcag aaggacgggt ctgccgtatt cgtcctgggt 608101 gcctgccagt tttaacgttc tgatgttttg tattctttca tgctgtaccg aagggtatga 608161 ggcgaggtac ttcggctttc tgctttcgtc tttttgtgcc aatggttttg tgactctgaa 608221 ttgcatgata ttcgcatctg tttcaggatt gacgtcaccg ccgcagcccg cgctgtttgc 608281 caaaatgatc gattctcctt catatgctgt gaagtcaatg atgatatcgt aacgttcagc 608341 aggcgcaagg ctgaaagaat tcagtttaac agatcgcggc aggagccctc catctgaacc 608401 aatctgaata aaatctccgc cattatcgag tgacaggtta taggttcttg tattggaggc 608461 gttgatgaca cggaatcggt atttccttgg ctcgacttcc aagtatggcc ataccttccc 608521 gttgacgagt atggtttctc cgcaaaaagc cggaacgatt gaaggattag gcagtgacgg 608581 agaagggttt tccggtgcgc tcggataaaa caaagaacca tcctcattga tcgtgcggtc 608641 tgtgataaga agcggcacat cgtattcgtc tgaaggcagt tttaagcgtt tttcctttgg 608701 gtcatgaatg atatatgcac cgacaagtcc ggcatagaca tttagcctgg tgagcgccat 608761 ggcgtgatcg tgataccaca atatagcccc gcgctgctgg tttggataat gataaacctc 608821 tcttttgaaa taaggtcctg tttgttcaaa gtctttggaa aaccaagcct ccggataccc 608881 gtcactatca tctggcgtga cgccgccgtg taaatgaaca acagtcttta cctcgggctc 608941 ttcatgctgg ctgtcactgt gatgaatggt gtgatcaatc ggaaggaaat gcgtggaagg 609001 aaggttattc atccatttta catatacgtt ttcatttctt ttaacctcaa tggtcggtcc 609061 cggaaataag ccgttgtagc cccacaggcg ggttggaggg agatcgcgat ggagctgatg 609121 agtgcattcc tccatggtga cttcgtagta tgttttttct tttgattgct gtactggctt 609181 tagtgtatct gggattggga gagcatccac aaatttttca agtgtcattt tcatctgtcc 609241 ttatctaaat tttccaaatt ggtactatag ttaatgacaa taaggacgtg atggttacaa 609301 aaaatcttcg tgctgcagcc cgcccgaaga agaaaataac aaaatcctaa acggcaggcc 609361 gtttaggatt tgatcagcat taaggcagga tatcgggttg ctgctgtgtg actgggttgg 609421 cagccgcttt ctcgctcacc ttgcgttttc tgaacacaag gtaagaaatc agaacgattc 609481 ccgtgatgac gcctgtcagc agcagctcgt ctctcatgga atcaataaac gccatggaca 609541 ctaaaattcc gcaaatggcg atgatggtca agtaggttag gaaagggaag agccacattt 609601 tgatcttcaa tgcttctggg tttgtttttt cgagtttttt ccgcattttc agctgggaaa 609661 cggcgatgac aagatagacg agtaaagcga ttgcgcctga tgagttgact aagaataaaa 609721 agacggtatc cggtgaaaaa tagttcatta cgaccgcgat ataagagaaa aatgtcccgg 609781 ccacaatggc ttgtacggga acgccttttt tgctcaattt cataaaacgg cgcggcgctt 609841 catttctttc tgcaagtgaa tacagcattc tggatgtggt atacaaacct gaattcaggc 609901 aagagagtac ggctgtgagg acgataaagt tcataatctg tgcggctgcg ggcactccta 609961 tatgctcaag tacagcgacg aaagggcttt ctaaaatatt tgctgaattc catggcaaca 610021 gcgccacgac aatggcgatt gagcccacgt aaaagacgat gatgcgccat acaacggatc 610081 tggtggcttt tgtcacagat tcgatcgggt tggatgtttc ccctgctgca atggcaacga 610141 tttcagttcc cataaaagag aagatgacaa cgacaatgcc gagcaatacg gagctgatgc 610201 cctccgggaa aaatccgcct ttgcctgtaa gattcgaaaa accgactggc tcactgcccg 610261 gtgcaaagcc aaaaataaag gcaaaaccaa cgattagaaa agcaatgata gtcacaactt 610321 taatgaggga gaaccaatat tcaaactcac cgaaagactt aacggagtag acgtttgtca 610381 gggtgagcac aatggtcaag atcaaacttg tcagccacag cggaatatca tggaaccagt 610441 attgaataat gccagcaccg gcaatggctt cgatcgctat gacgatcacc cagaaaaacc 610501 agtacagcca gccgattgta aatcctgccc acggtccgat ggcgtcgtga gcgtattgag 610561 aaaacgatcc gctcgtcggg tttacggcag acatctcacc gagcattctc ataataaaaa 610621 tcaccaataa tccggctaac gcgtaagaaa caacggcacc cggaccggtc gagtgaatca 610681 ctgaaccgct gcctacaaat aggccggctc cgattacacc ggcaatcgaa atcattgtca 610741 tatggcgggt ctttaattcc ttttttaatc ctgattgaga ctggttcata agttacctcc 610801 ttttaaaatg caatcattac tgaatattat gataattgaa actctatcat aaatatacag 610861 tttgtcgaaa attcgtgtaa gaaaatatac cagcttattt caaatttgta gtgttttgtt 610921 tgcgctttca gcgaatgtgt ggaaaaaatg tttcgttttt tattcgctgt gtgattttgc 610981 gtaatattta caattcgata gaatgcgaga agcactggtg tccttgggtt tgatgggatt 611041 tttggcggag caaataaatt ggatgagaga aaaagtgttc cttcgtcact atttttctgt 611101 ggcgggtgaa tcatgtttct gtagacccac tgcggatcag ctttgtaaga taataatagg 611161 aaaatgtgag cgagaggagg ttttgtatgg agagatatga tgaactgaaa aagggagaat 611221 ccggagcgct ggtcagcatt gccgcgtatc tagttctttc cgcaattaaa ctgatcatcg 611281 gttatctttt tcactcggaa gcacttacgg cagacgggtt aaataacaca actgacatta 611341 ttgcttctgt tgctgtgctg attggcctgc gcatctctca aaagcctcct gacgaagatc 611401 atccatacgg ccactttcga gcggaaacga ttgcatcgct tatcgcatcg tttattatga 611461 tggttgtcgg actgcaagtg ctgttcagcg ccggagaatc tattttttct gctaaacaag 611521 agacgccaga tatgattgcg gcttggacgg cagcgggcgg ggcagtcctg atgctgatcg 611581 tttaccggta caataaaagg ctggccaaaa aggtgaagag ccaggcgctc cttgctgcgg 611641 ctgctgataa taaatcagac gcattcgtca gtatcggcac atttatcggc attgtggctg 611701 ctcaattcca tcttgcttgg attgatacgg tcactgcgtt tgtgatcggt ctgcttattt 611761 gcaagaccgc atgggatatc tttaaagagt catctcactc tttgacagat ggattcgaca 611821 taaaggacat ttccgcttat aaacagacaa tcgaaaaaat ctccggtgtg agccgtttaa 611881 aagacataaa agcaagatac ttgggcagta cggttcatgt tgatgtggtg gttgaggtat 611941 cggcagattt aaatattacg gaaagccacg atatagccaa tgaaattgag cggagaatga 612001 aggaggagca tgcgattgat tattcgcatg ttcatatgga gcctttagaa caaaaataat 612061 ggagcttcct gtcacaggaa gcttcagcgt gtcgacaaac cctcgcattc gttgtcaggt 612121 ctgcgcttcg gtgctcacga attagaacat tcgctccgct cctatgctcg tccttcctag 612181 acttcaaggg ttttcaatca cgctgaaaag atgacaaaac cctaaaatga aagccatttt 612241 aggattttgt caacaatctg gagcttcctg ccacaggaag cttttttgtg tgttttggcc 612301 agctttattg gtaacaattt gctagaatcg tttttttata cagattgctt tttgtggtaa 612361 agttaggtta cattatgatg aattttgtag atgactagga ggaaaataat ggcatatcaa 612421 gaagacctgc atcctttgct ggggaaagca gttgaacata ttaatagagt aatggttgga 612481 aaacgagaca tcgccatact cagcttagca gcccttcttg ccaaagggca tgtgctgctt 612541 gaggatgtac ccggagtcgg aaaaacgatg atggtccgcg cgctggcaaa gtcaatcggc 612601 gccgatttca aaagaatcca attcactccg gatttgctgc catctgatgt aacaggggta 612661 tctatctata atgcgaaaac gatggaattt gaatatcgtc ccggcccaat tatgggaaat 612721 atcgtgctgg cagatgaaat caaccgtacc tctccgaaga cacagtcggc tttgctcgaa 612781 gcgatggaag aggggagcgt cacggtagat ggccatacga tgcagcttgc cgatccgttt 612841 tttgtgatgg caacgcaaaa cccggtcgaa tatgaaggga cctatccttt gccggaagct 612901 cagcttgacc gttttttatt caaacttcgg atgggttatc cgtcctttaa tgaagagctt 612961 gacgtcttat ctcttcagga aaaaagccat ccgattgaga cgcttgagcc ggttattgca 613021 aaagaagact tcatcttttt acagagggaa gtgcaaaatg tccgtgctga tgacagcatt 613081 aaggaatata tcgttgaaat tgtgcagaaa acgagacagc atccttctgt tcaattaggc 613141 gtcagtccgc gcggctcaat cgccctcatg aaagcggcac aggcatacgc gctgctgcat 613201 catcgcgact atgtcatacc ggatgatatt caatatttag ctcctttcac gctgccgcac 613261 cggatgatgc ttcatcctga ggcaaaattt gaagggattc aggcagaagc gatcgtaagg 613321 gagatcatgt cagctgtgaa ggtgccggtt caaaggtcgg cggtccgctg atgaataaga 613381 aatggcaatg gctcgtatat ggttggaagc tgattatatt aactttattg acggctgctg 613441 ttttttctta tgcgatgttt cagggcggct ttgtcagctg gtttttgttt tacgcgtttc 613501 tcccttttgt cttgtatgcc gggctgttgg ccttgtatcc gctccgttct tttcaggctt 613561 caaggcaaat ggataaaaca caattgcatg cgggggacag gctgggcgta acggttacgc 613621 tgagaagaaa gctgccattt ccgctgatgt atatggtgat tgaagattgc ctgccagaag 613681 gtatcgagtc attaaatcga gacggagccg cggccaaacg gctcgttttt ccttggttta 613741 aacggagcat gacgatgtcg tatgaattag ctcgggtacc gcgcggagag catcactttc 613801 attctgtcag ggtgcgaacc ggggatgttc ttggcttgat tgaaaaaaca gcattttttg 613861 agctggatga taccttgttt gtttatccat tctatcagcg tttttcctat caggtgaatg 613921 agaggcatca ggaagacggt gtaagcggtt cttctcctat tcatcagcac cattcctcag 613981 tcgcagcaag tgtgcggaat tatcagccgg gagaccggtt tgctgcgtta gattggaaga 614041 catctgcacg gcggagccag ctgatgacga aggaatttga gccttctcgc agcaaaaatc 614101 tgtttctgct gatggaccgt ttttcctcag acgcattcga agaggtcgtt tcagtgacag 614161 cttcgattct tcattctgtt ttaaaaaacg gcgcgggtgc tggtctggct tccatcggga 614221 aggaaaaaaa cattttccct attcaggaag gggatcagca ttttaagcac atgcttcggc 614281 atttagccat cgctcattgt gatgcggcag acccgataag ccgatatgca cgggaagagc 614341 tgggaaagcc atctgttcgc caagctgatc aagttgttgt cacgggacag ttaacggaag 614401 atatgctgca cctcgcagaa ataggaggcg gccgggttac ggtgatactg gcaaaagaga 614461 aagatgctga gctctctcaa gctgaaaatg tcatgattga acgcatgatg aaacgccaaa 614521 tcagagttcg gatcatgagg ggcgggcgag tttcgcgtgt tgtttagaaa gagaggtgac 614581 tggttcacat gccgcacgat gatcacaagg gaagccgttt gagcttgctg ttattttatt 614641 ttctggcttt tttattgctg tgggagtggc ttaggccgct tgacagtttt actgaaacga 614701 aacatacagg cttttttagt gtctttatcg gcttgacgtt tctgctgact tttttcagga 614761 tgaggtggtt tgtcaccgtt cctttttgtg tcatatttac attgatctcg atacacatcc 614821 tgttttatca aggatctata ttcgacttga gctgggtcag ctcttttttg caggatgtct 614881 atctgaatat cacgctgatt caatcagggc aatggaatga catgattcct tcatttcgga 614941 ccctgctgtt ttttgtgctg ctgtggctgc tggtctatct cctgcattat tgggtgattt 615001 accagagaag aattttgttt ttctttttga tgacagtagc gtatattacg attcttgata 615061 cctttacgcc atatgatgcc acttttgccg taatccgtat cgtgctgatc ggcttcttta 615121 tgctgggcct tttatacttg gaacgcatta agctgatgga aagaatcaca ctgccaaaaa 615181 catctgtcct gaaatggttt cttcctttat ctgtattggt tttggctgca acgggattcg 615241 gactcgccgc tccaaaatca gagccggctt ggcctgatcc ggtgcctttt cttaaaaaaa 615301 tcactcatca agaccgcgtg tctgcagggg aaagcaaaat cggatacggg aatcatgatg 615361 aatcactcgg cggcccgttc cagcaggatg ctacacctgt ttttacatgg cagggaaaag 615421 agcgtacgta tttccgtgtg gaaacgaagg acacgtatac cggaaaaggc tggattgaaa 615481 cagacacagg catgtcgtat cagcttagca atggaaaagt tgaaaatctg tggtttgacc 615541 ataaggttgc gacagagcgc cgcaccgtcc gtgtaaaagt cgataagcac tacgggtata 615601 accatctgat gtatccgatt ggtgcggaaa ccattcagcc aaagcaggct gtctcacttg 615661 aaatgaacgg caacacggag caaatttctc cgatcagtga acaagccggt gaaatcagaa 615721 atatggggaa ttatacagta acgtacaatt ccccggtcta taagctggat gaactgagaa 615781 aggtaaaagt gagaaaaaac agtgaggagt acacattcag cgatcgctac atgcagcttc 615841 cagattcact gccagagcgg gtgagaaccc ttgcgatcaa actgactcag gatcacgaca 615901 atatgtttga taaggtgaaa gcggttgagg actatttagg gtcaaatgcg ttcacatatg 615961 aaacagaaaa cgtgaccatt ccgaagaatg atgaagatta tgtcgatcaa tttctctttg 616021 aaacgaaaat gggttattgt gataactttt cttccgccat ggtggtgctc ttgcgctcgg 616081 ccggcattcc ggcccgctgg gtaaagggtt atacgtccgg cgaatacaaa gaagcaggga 616141 acaaaaatgg cagcatttac gaagtgacaa ataacaatgc ccattcctgg gtagaggtgt 616201 atttcccgga acagggctgg gttacatttg agccgactaa agggtttaca aatccggctc 616261 aatttacatc ttctgacaca aaagactctg gcagcgatag cagcagctcg ccgaagaaag 616321 caaaagagaa acagaaagaa gagaaaaaac agccgcaaaa agaggaaaaa caaaaggaaa 616381 agcgggagcc agctgtttct aaaaagccgt ccgcttcgca tactaatgcc ggtgcgggct 616441 tgtatgcagc gcttgcggtt cttgcagtcc tcctggtggc agctgtattg ctgtatgttt 616501 tccgctcgtt atggattcct gttttcgccg tgaggaaatt gaagcggcgc agtgatcagc 616561 acgcgttttt tgaggcatat ggcgcgctgc tgaaacaact gaagagaaaa ggactgccga 616621 aacgagacag tgaaacgctg cgtgattatg caaaacgaat tgatgaaaaa tacgacatag 616681 aagacatgtc aaagctgaca ttaagctatg aaagggcgct ttacagaaat gaagattctt 616741 cggcgctatg gaatgattcg agagagttat gggaaaattt aattaaaaga agatggtctt 616801 gaccgcttat cgacgtgttg ttagaattag tgaatattat cggagtctgg gagcgagttg 616861 gcctgactcc ggcaaacggc cttgccaaag agggcggagc gagcttcata tctgtcctcg 616921 tttttttctg tgtcaaaaaa cttagaggag attaggtgac aaccatgaca aagttagtga 616981 atgaaatgat tcttgtcctt gatttcggca gtcagtataa ccagctgatt acacgccgta 617041 tccgtgaatt cggtgtttac agcgagctgc atccacatac attgacggct gaagaaatta 617101 aaaaaatgaa tccaaaagga attattttat ccggcggtcc aaacagtgtg tatgatgaaa 617161 actctttccg ctgtgacgag aaaatcttcg agcttgatat tcctgttttg ggaatttgct 617221 acggcatgca gctgatgact cattaccttg gcggtaaagt tgaagcggca agccagcgtg 617281 aatacggaaa agcaaacatc cgcatcgaag gcacacctga tttgttcaga gatcttccga 617341 atgaacaagt ggtttggatg agccacggcg atttggttgt agaagttcct gaaggcttca 617401 ctgttgacgc gacaagccat cactgcccga actcagcaat gagcaaagcg gacaaaaaat 617461 ggtatggcgt tcagttccac ccggaagtgc gccactctga atacggcaat gatcttctga 617521 aaaactttgt attcggtgtt tgcgaatgcg aaggcgaatg gtcaatggag aactttatcg 617581 aaatcgaaat gcaaaaaatc cgtgaaacgg tcggagacaa acaggttctt tgcgcgctaa 617641 gcggcggcgt tgattcctct gttgttgctg ttttgattca taaagcgatc ggcgaccagc 617701 tgacttgtat ctttgtagac catggtcttc tccgtaaagg cgaagctgag ggtgttatga 617761 aaacattcag cgaaggcttt aacatgaatg tgattaaagt agacgcaaaa gatcgattct 617821 taaacaaact aaaaggcgtt tctgatcctg agcaaaaacg caaaatcatc ggtaatgaat 617881 tcatttacgt gtttgatgat gaagcggaca agctcaaagg catcgactac cttgcacaag 617941 gtacgcttta cacagatatc atcgagagcg gtacagcaac ggcgcaaacg atcaaatctc 618001 accacaatgt cggcggactt cctgaagaca tgcagtttga gctgatcgag ccgttaaata 618061 cgctcttcaa agacgaagtg cgcgcgcttg gcacagagct cggcattccg gatgaaatcg 618121 tatggcgtca gccgttccca ggaccgggac tcggaatccg cgttcttggc gaagtaacag 618181 aagaaaaact tgaaatcgtt cgtgaatcag atgcaatctt gcgtgaagaa attgcaaatc 618241 acggcttaga gcgtgatatc tggcaatact tcactgttct tcctgacatc cgcagcgttg 618301 gtgttatggg tgacgcaaga acatatgatt acacaatcgg aatccgcgcc gttacatcaa 618361 tcgacggcat gacatctgac tgggcgcgta tcccgtggga tgtgcttgaa gtcatttcga 618421 cacgtatcgt aaacgaagtg aagcacatta accgcgtggt gtatgatatt acaagtaagc 618481 cgcctgcgac gattgagtgg gaataagaat caattaatgg aaaccatctt tttggcaatt 618541 ttgccgggaa gatggtttta tttgtttatt acgaacaaaa tccgattttg cgcgactatt 618601 gttcgctttt tgtattgttt tttcaaaatg aacttggtac aatagacaca gaaatcaaat 618661 aagatgaatt cgtataatcg cgggaatatg gctcgcaagt ctctaccaag ctaccgtaaa 618721 tggcttgact acgtaaacat ttctttcgtt tgatataaat aaaacacggt tatttattca 618781 aactgaaatc cgtctgtagt caagcgtccc aaaatgtatt gggacgtttt ttatttggcg 618841 ttttcaggac agaataaata gcaaagagtg aagggagtca aatagcttga aaacgttttt 618901 tcagtttgat gagctgggca ccagctatcg caatgaaatc attggcggat taacgacttt 618961 tttatctatg gcatatattt tgttcgtcaa tccgattacg cttgctttgg agagcgtgaa 619021 agattttccg gaggcgctga gaattgacca gggtgcggtc tttacggcga cagcgctggc 619081 gtctgcagca ggctgtatct taatgggatt aatagcgaga tatccgattg ccatcgcgcc 619141 gggtatgggg ctgaacgcgt tttttgcgtt ttctgttgtc cttggtatgg gtatttcatg 619201 gcaggcagct ttgtccggtg tttttatttc aggtcttatt ttcgttgctc tttctttaac 619261 aggttttcgt gaaaaaatca tcaacgccat tccgcctgag ctgaaattgg cagtcggtgc 619321 ggggatcggc ctgtttatta catttgttgg attacaaggt tcaggaatca ttacagcgaa 619381 tccttctacg ctcgtcacga tcggaaacat tcacagcggt cctgtgctgt taacgatttt 619441 cggtgtgatt gtcacggtta ttttaatggt gcttcgcgtg aacgcaggcg tgtttatcgg 619501 gatgctatta acagcggtag ccggcatgat tttcggtttg gttccggttc cgactcaaat 619561 tatcggcagt gtgccaagcc ttgcgccgac tttcggacaa gcgtggattc acctcccgga 619621 tattttctct gtacaaatgc tgatcgttat tttaacattc ttgtttgtcg gattttttga 619681 tacagctggt acacttgttg ctgtggcaac acaagctggt ttaatgaagg aaaacaaatt 619741 gccgcgtgcg ggccgtgcgc ttttagctga ttcatcttct attgtgatcg gtgccgtgct 619801 tggtacgtct acaacaactt cttacgtgga atcaagctca ggtgtcgctg cgggtgcccg 619861 gtcaggattt gccgcaattg taacagggat tctcttttta ctggctacgt ttttctcgcc 619921 gctcctatca gtcgttacgt caaatgtaac agcgccggcg cttattattg ttggtgcatt 619981 gatggtggcg ccgcttggca aaatcgcttg ggataagttc gaagtggccg ttcctgcttt 620041 ccttaccatg atcatgatgc cgttaacgta cagcatcgcg actggtattg ccatcggatt 620101 tattttctat ccgattacaa tggtgtgcaa aggaaaagca aaagaggttc atccaatcat 620161 gtacgggctg tttgtcgtat ttatcctgta ctttatcttc ttaaaataag gaatgaaaaa 620221 ccagctgcac tggcagctgg tttttttgtt gcaaaagata aaaccatttc atacgatata 620281 ccgtcatgta gatgtgccgc catgctttac ttaaatggaa atgacttgac tgttcaggaa 620341 ggcttcggta ccttatataa gtgttttatt ttcttgctga atggtattcc gccgtatttt 620401 tttgatagga gttgctgaca tgacggaaga aagaaaagaa acgtttgaag aagaaattaa 620461 ccagagtgaa agaatagatg cagatgaaga accgctatcg agaatgtcca gaaaggcgag 620521 ccggcaaagc aagcagaagc aaaaacaaaa gcagaaaccg cgccaggaac gcggtgaatc 620581 aactgttaaa gacaagcttg cgtctgtttg ggcagccatc aacagatatt gcggttttgc 620641 gttctcgatt ttaaaatctc cggcgaaaac tgtcgtaacg gatggttttt ctcattataa 620701 gtacggtctg atttcaatgc ttatattcag tatcattttt tcaattggga attggtttca 620761 gttaaaggca agctggaatc ggccgctcgg tttcggagaa cgccatcatg ctttctatga 620821 cgggttttta gttgttcttg tgtatttgct gatctttttc gcggtaatgg tctttgctat 620881 atgggctgtc tcccgctata tgatgaagca gaaggtgacg ttcagagaag cggctgccgt 620941 attgggttca ttgcttgtac ccgtaattgc tgtttcaatc ctttggctga tctttgcgat 621001 cgtaaatatc ccaatgctga cagtactgtt tacggtgctg atcttgtttt ccatcttttt 621061 tatcatcgcg ctgtatgtac agcgtgtgta ccaggcggca caagatgcac caattgatta 621121 tatctattgt gtatttgcag tagttgcgat agcgctgctg tttacggcag tgacttggcc 621181 gtttatttct gaatatatta cggcgtcgtt gattccgctt taatgaaaaa accggctaat 621241 cctagccggt ttttttatgt cacacttttt acaaatatat ctaaaaaaca tagttgattt 621301 gtaggattaa cccgtgtatg atggggaaaa tgctgaaaac gtccagcgca aaaaccttta 621361 tgtttaagga ggatgatgga catggctgat gtacttcgcc gagcaattaa ccaaaagaag 621421 caatttttaa aaaccaaatt actgctctcg gaattttatc aaggaagagg ggaacagctt 621481 gctgactaca cgctgagtga gcttgagaaa gaatacaagt cccttcagaa aatgaaaaaa 621541 gagatctgac aatagatata aagaggtgag tctgctgaaa agcgggcttt tttgttttga 621601 ttttgaaaag gcgagaaaga gggtaaacta ctactgttca acacataaaa gcgtgtcgaa 621661 atattttgct taagcttacg ggcgaagctg attgtaaacg gctcatttct ctagtagaat 621721 atgaatgctt tgtgcaagct gaagagtagg gggatgaata aaatgatgca aaccatctta 621781 tcaaatggga tagccatggt tctcataatt ctcattatta atattgtcta tgtgtcattt 621841 tttacgataa gaatgatttt aacgctgaaa ggacagcgtt atttagcggc cggcatcagt 621901 acgattgaaa tactggttta tgtgacagga ctgagtctgg tgctcgataa cttagaccag 621961 attcaaaatg tgatcgcgta cgcgctcggt tacggtcttg gcgtaattgt cggcatgaaa 622021 atagaagaaa aattggcgct tggctatatt atggtcaatg tgattacgaa ggagctcgat 622081 cttgatcttc cgaagcagct ccgtgaaaaa ggctacggcg tgacaaactg ggtggcaggc 622141 gggcttgaag gcgaccgcac agcccttcag atcctgacgc cgagaagata tgaactccag 622201 ctatatgata cgattaaaac acttgattca aaagccttta ttattgcgta cgaaccaaaa 622261 acaatccacg gcggcttctg ggtcaaagcg gtgaagaaga ggagaattaa agaataatgg 622321 caaagccgaa gaagaaaaag tttgaagtga cagagcagca aacgattgat gcggtgcttc 622381 agcaaatgaa agaagaagga tatctgcctg taaggcgaat ggaagagcct atttttatgg 622441 aaaaaaagga aaatgggtca attcagatcg ttccgtgcgg gaaaaaaatc gtatttgaag 622501 ggaaattgat ctaaaacacg aacattagta gaatgaattt ttgtatcgtt cgataatatc 622561 gttgacatta tccatgtccg ttgttaagat aaacatgaaa tcaaaacacg acctcatata 622621 atcttgggaa tatggcccat aagtttctac ccggcaaccg taaattgccg gactatgcag 622681 gaaagtgatc gataaaactg acatggatat atcgcagaag cgaacgactg acgatacatg 622741 taccatgccc ggtttgtatt gcttcctcat aagtgcaatg cagagcgggt attttttatt 622801 ttctgaaaac aaaagcatta gaaggtgggg aacagaatgc agccgctagt aggaatcatc 622861 atgggaagca cttccgattg ggagacaatg aaacacgcat gcgacatact tgacgaactc 622921 aatgttccgt acgaaaaaaa ggtcgtttcc gctcaccgga cgcctgattt catgtttgaa 622981 tatgctgaaa ctgctagaga aagaggcatc aaggtgatta ttgccggtgc cggaggagcg 623041 gcgcatctgc cagggatgac ggctgcgaaa acaacactgc cagtcattgg agttccggtt 623101 cagtccaagg cgctgaacgg aatggattca cttctttcca tcgtccaaat gcctggaggc 623161 gtgcctgttg cgacaacatc catcggcaaa gcgggtgctg tgaacgcagg cctgttagcg 623221 gcgcaaattt tgtcagcatt tgacgaagac cttgcccgta agctggatga gagaagagaa 623281 aatacaaaac agacagtgtt agaaagcagt gatcagcttg tctaaacaaa tcatctatcc 623341 gggagctgta atcggcatta tcggcggcgg ccagcttggg aaaatgatgg ctgtgtccgc 623401 caaacaaatg gggtataaag tcgcggtcgt tgatccggtg aaagattcgc cgtgcgggca 623461 ggttgcggat gtcgaaatta ccgctcatta taatgaccgt gaagcgattc gaaaattggc 623521 tgaaatcagc gatatcatca catatgagtt tgaaaacatc gactatgatg cgctgcattg 623581 gctaaaagat catgcgtatc tcccgcaagg aagtgagctg ctgcttatta cccaaaaccg 623641 tgaaacagag aaaaaagcaa ttcaatccgc gggctgtgaa gtcgcaccgt acagcatcgt 623701 caaaacaaag aatgaattga aacaggcagt acaggagctc aggcttccgg cagtgctgaa 623761 aacatgccgc ggcgggtacg acggcaaagg ccaatttgtg ataaaagaag aggcgcaaat 623821 ggagcaggca gccgctctgt tagaacacgg aacttgcatt cttgaaagct gggtttcttt 623881 taaaatggaa ctgtcggtga tcgtcgttag atcggtaaac ggtgaaattt caacatttcc 623941 gacagctgaa aacattcacc acaacaatat tcttttccaa agcatcgtgc ccgcacgggt 624001 agagaaaggg attcagcaga aggctgctga tctcgcagtt aagcttgcag atgagcttaa 624061 ccttgtcgga ccgcttgctg ttgagatgtt cctgacagag gacggagagc ttttggtcaa 624121 tgaactggcg ccaagaccgc acaattcagg gcattatacg ctggaccttt gcgagacgag 624181 ccagtttgag cagcatatca gagcggtatg cgggcttccg cttgggaaga cagatttgct 624241 gaagccgggc atgatggtga atcttctcgg cgatgaagtg aagcttgttg aggaagaccc 624301 ggagctttta aaagaggcaa agctatatat atacggaaaa catgaaatca aaaaaggccg 624361 caaaatgggg catattacat ttatgaagca gcctgaagac gaatggattc aggagatcac 624421 aaataaatgg atgaatagag acggaggaca agcagaatga tcgaacgtta ttcaagacct 624481 gaaatgtccg cgatttggac ggatgaaaac agatttcaag catggttaga ggttgaaatt 624541 cttgcctgtg aagcgtgggc ggagcttggc gtcattccga aagaagatgt aaaggttatg 624601 cgcgaaaacg cgtcatttga catcaaccgc attttagaaa tcgaaaagga cacgcgccat 624661 gacgttgtcg cttttacgcg cgctgtatcc gaatcactgg gcgaagaaag aaaatgggtg 624721 cattacggct taacgtcaac tgacgttgtt gatacggctc tttcctactt attaaaacag 624781 gcaaacgata ttttgctcaa ggatcttgag agatttgttg acattataaa agaaaaagcg 624841 aaagaacata aatacacagt catgatgggg cgcacacacg gcgtacacgc tgagcctaca 624901 acattcggct taaaacttgc gctttggcat gaagaaatga aacgtaatct tgagcgcttc 624961 aaacaagcga aagcaggcat cgaggttgga aagatttccg gtgctgtcgg cacatatgcg 625021 aacattgatc catttgttga acaatatgtc tgtgagaagc tcggattgaa agcagcaccg 625081 atttccactc aaacccttca gcgtgaccgc catgctgact atatggcaac acttgctttg 625141 atcgcgacaa gcatcgagaa attcgctgtg gaaatccgcg gactgcaaaa gagtgaaaca 625201 cgtgaagtag aggaattttt cgcgaaaggg caaaagggtt catctgcaat gccgcataaa 625261 cgaaatccga ttggctctga aaacatgaca ggcatggcgc gcgtgatccg cggctacatg 625321 atgacagctt acgaaaatgt tccattatgg catgagcgcg atatttctca ttcttcagca 625381 gaacgaatta ttcttccgga tgcgacaatt gcgctgaact acatgctgaa ccgcttctcc 625441 aacatcgtga agaacttaac ggtcttcccg gaaaacatga agcgcaacat ggaccgcact 625501 ctcggcctta tctattctca gcgtgtgctc cttgctttga ttgacacagg cctgactcgt 625561 gaagaagcct atgatacagt tcagccgaaa gcaatggaag cgtgggaaaa acaagtgccg 625621 ttccgcgagc ttgtggaagc ggaagagaaa atcacgtcac gtctttctcc agaaaaaatt 625681 gctgactgct ttgattacaa ttaccatctg aaaaatgttg atctgatctt tgaacgttta 625741 ggtttagcat agaagaagct tttagcggct tcttctaagc cgccgcagtt tgaaaattcc 625801 caacattcgg gttaggaggc cttccgtgaa tattgtgaag aatgaacttt tatacgaagg 625861 aaaagcaaaa aagatctaca aaaccgatga cgaaaacacg ctgtatgtcg tgtataaaga 625921 ctccgccact gcctttaacg gcgagaaaaa agcagaaatc agcggaaaag ggcgcttaaa 625981 taatgaaatt tcaagcctca ttttcaaaca ccttcatgct aagggcatta acaatcattt 626041 tatcgagcgc atttcggaaa cggagcagct cattaaaaag gtaacgattg tgccgcttga 626101 agtcgtggta agaaatgttg tggcaggaag catgtccaaa cgtctcggca ttccagaagg 626161 cacggagctt gagcagccga ttatcgagtt ttactacaag gatgacgcgc tgggtgatcc 626221 gctcatcaca gaagatcata tttggctttt gaaggcggcg actcctgagc aggtagaaac 626281 cattaagtcc attacaacaa tagtaaatga agagcttcaa agcatcttcg acgattgtca 626341 tgtcagatta atagatttca agcttgaatt cggtttagat gcagaagggc aagtgctttt 626401 ggcggatgaa atatctcctg acacatgccg cttgtgggat aaagaaacga acgaaaagct 626461 ggacaaagat ttattcagac gcaatctggg aagcttaacc gacgcatacg aagagatttt 626521 caatagactg ggaggcattc atcatgtata aagtaaaagt ttatgtcagc ttaaaagaaa 626581 gtgtactaga tccacaaggg agcgctgtcc agcatgcctt gcacagtatg acttacaacg 626641 aagttcaaga tgtgcgcatc gggaaataca tggagcttac cattgaaaaa tctgaccgtg 626701 atcttgacgt gctagtgaaa gaaatgtgcg aaaaacttct tgcgaacaca gtgattgaag 626761 attatagata tgaggttgag gaggtagtcg cacagtgaaa tttgcggtga ttgtgttacc 626821 cggctccaac tgtgatatcg atatgtatca tgctgtaaag gatgagctcg gccatgaagt 626881 ggaatacgtc tggcatgagg aaacaagcct tgacggcttc gacggcgtgt taattccggg 626941 aggattttct tacggcgatt acttaagatg cggcgccatc gcccgatttg cgaatattat 627001 gccagctgtc aaacaagcag cggctgaagg aaaacctgtt cttggcgtct gtaacggatt 627061 ccagatttta caggagcttg ggctgctgcc aggcgcaatg agacgcaaca aagatctgaa 627121 gttcatttgc cgtccggttg aattgattgt tcagaacgac gaaaccttat tcacagcttc 627181 ctacgaaaag ggagaatcga ttacaatccc ggttgcccat ggtgaaggga atttctactg 627241 tgatgacgag acgcttgcta cattaaagga aaacaatcaa attgctttca catacggctc 627301 taatattaat ggaagtgtca gcgacattgc cggtgtcgtg aatgagaaag gcaatgtatt 627361 aggcatgatg cctcaccctg agcgcgcggt cgatgaactg cttggaagcg ccgacggtct 627421 taaattgttc cagtctatcg tgaaaaattg gagggaaact catgtcacta ctgcttgaac 627481 caagtaaaga acaaataaaa gaagagaaac tgtatcagca aatgggtgtc agtgatgatg 627541 agtttgcatt gatagaatcc attcttggaa gattgccgaa ctacacagaa atcggaattt 627601 tttctgtcat gtggtctgag cattgcagct ataaaaactc aaagccgatt ctgcgtaaat 627661 tcccgacaag cggcgagcgt gtgctgcagg ggccggggga aggcgccgga atcgttgata 627721 tcggtgataa ccaagcggtt gtgttcaaaa ttgaatcaca taaccaccca tcagctctcg 627781 agccttacca aggcgctgcg actggcgtag gcggaattat ccgtgatgta ttctcaatgg 627841 gtgcacgccc aatcgctgta ttgaactctc ttcgatttgg tgaactgact tcaccccgcg 627901 tgaagtactt gtttgaagaa gtagtagcgg gtatcgccgg atacggcaac tgtatcggca 627961 tcccgacagt cggcggagaa gtgcagtttg acagcagcta tgaaggaaat ccgctcgtca 628021 acgcaatgtg cgtcggttta atcaaccatg aagacatcaa aaaaggccag gcaaagggtg 628081 tcggcaacac agtaatgtac gtaggagcga aaacagggcg tgacggcatc cacggcgcta 628141 cgtttgcttc tgaagaaatg tcagactcgt ctgaagaaaa gcgttctgct gtccaagtcg 628201 gcgatccgtt tatggagaag cttttgcttg aagcatgtct ggaagtcatc caatgcgacg 628261 ccttagtcgg cattcaggat atgggagctg ccggtttaac aagctcaagt gcagaaatgg 628321 caagtaaagc cggttctggc attgaaatga atcttgacct gattcctcag cgcgaaacag 628381 gcatgaccgc gtatgaaatg atgctttctg aatcacaaga acggatgctt ttggttattg 628441 agcgcggacg tgagcaggaa atcatcgata tttttgacaa gtatgatctt gaagcggttt 628501 ctgtcggaca tgtgacagat gataaaatgc ttcgcctgac acataaagga gaggttgtgt 628561 gcgagctgcc tgttgatgcc ttggcagaag aagcaccggt ttaccataag ccttctcaag 628621 agcctgctta ctatcgcgag tttttggaaa cagacgttcc ggctccgcaa attgaagatg 628681 cgaatgaaat gctgaaggcc cttcttcagc agccgacgat tgcgagtaaa gagtgggttt 628741 atgatcagta tgactacatg gtgcgcacga atacagttgt cgctcctggg tctgatgctg 628801 gtgttctcag aatccgcgga acgaaaaagg cgctggcgat gacgacagac tgtaacgcgc 628861 gttatctcta tcttgatcct gaagtcggag ggaaaattgc tgtcgctgaa gcagcgcgca 628921 acatcatttg ctcaggcgca gaaccgcttg cggtgacaga taaccttaac ttcggaaacc 628981 ctgagaagcc ggaaatcttc tggcagatcg aaaaagcggc agacggcata agcgaagcgt 629041 gcaatgttct cagcactccg gttatcggcg gtaacgtatc gctttataac gaatcaaacg 629101 gcacggcgat ctatccgaca ccagttatcg gcatggtcgg cctaattgaa gatacagcgc 629161 acattacaac acagcatttc aaacaagcag gagatctcgt atacgtgatc ggcgaaacaa 629221 aaccagagtt tgccggaagc gagctgcaaa aaatgacaga aggccgtatt tacggcaaag 629281 cgccgcaaat cgatcttgat gtagagctgt ctcgtcaaaa agcactgctt gacgcgatta 629341 aaaaaggctt cgttcaatct gcgcatgatg tgtctgaagg cggcttaggc gtagcgattg 629401 cggaaagtgt catgacgacg gaaaaccttg gcgctaatgt gactgtagaa ggggaagcgg 629461 cgttattatt ctctgaatct caatctcgct tcgtcgtttc agtgaaaaaa gaacatcaag 629521 ctgcgtttga agcaactgtc aaagatgcag ttcatattgg tgaggtaaca gctgacggaa 629581 ttctggcgat tcaaaaccaa gacggacaac aaatgattca tgcgcaaacg aaagagcttg 629641 aacgcgtatg gaaaggagct atcccatgct tgctgaaatc aaaggcttaa atgaagaatg 629701 cggcgttttt gggatttggg gacatgaaga agccccgcaa atcacgtatt acggtctcca 629761 cagccttcag caccgaggac aggagggtgc tggcatcgta gcgactgacg gtgaaaagct 629821 gacggctcac aaaggccaag gtctgatcac tgaagtattt caaaacggcg aactcagcaa 629881 agtaaaggga aaaggcgcta tcgggcacgt tcggtacgca acggctggag gcggcggata 629941 cgaaaatgtt cagccgctcc tcttccgttc ccaaaacaac ggcagcctgg cgcttgctca 630001 taacggaaat cttgtcaacg ccactcagct gaagcagcag ctcgaaaatc aagggagcat 630061 ctttcaaacc tcttcggata cagaggtttt ggctcacctg atcaaaagaa gcggacactt 630121 cacgctgaag gatcaaatta aaaactcgct ttctatgctg aaaggcgcct acgcgttcct 630181 gatcatgacc gaaacagaaa tgattgtcgc acttgatcca aacgggctga gaccgctatc 630241 catcggcatg atgggcgacg cttatgtggt cgcatcagaa acatgcgcat ttgacgtcgt 630301 cggcgcaacg taccttcgcg aggtagagcc gggagaaatg ctgatcatta atgatgaagg 630361 catgaaatca gagcgttttt ccatgaatat caatcgttcc atttgcagca tggagtacat 630421 ttatttctcc agaccagaca gcaatattga cggtattaat gtgcacagtg cccgtaaaaa 630481 ccttgggaaa atgctggctc aggaatccgc agttgaagct gacgtcgtaa ccggggttcc 630541 ggattccagt atttcagcgg cgatcggcta tgcagaggca acaggcattc cgtatgagct 630601 tggcttaatc aaaaaccgtt atgttggcag aacgtttatt cagccgtccc aggctctgcg 630661 tgagcaaggc gtcagaatga agctgtctgc ggtgcgcggg gttgtagaag gcaaacgcgt 630721 cgtgatggtg gatgactcta tcgtgcgagg aacaactagc cgccggattg tcacgatgct 630781 aagagaagcg ggtgcgacag aggtgcatgt gaaaatcagt tcaccgccga tcgctcatcc 630841 gtgcttttac ggcattgaca cttccacaca tgaagaactg atcgcgtctt cgcattctgt 630901 tgaagaaatc cgtcaggaaa tcggagccga taccctctca tttttgagtg tggaagggct 630961 gctgaaaggc atcggcagaa aatacgatga ctcgaattgc ggacagtgtc tcgcttgctt 631021 tacaggaaaa tatccgactg aaatttacca ggatacagtg cttcctcacg taaaagaagc 631081 agtattaacc aaataaaact tgaaaaatga cataaaggca gcgcagttcg gctgcctttc 631141 tctttctgcc ctcgttcggg gagatatttt gaaaagcgcc ttaaaggagt gaataggatg 631201 tctgaagcat ataaaaacgc aggagttgac atcgaagccg gatatgaagc tgtaaaacga 631261 atgaaaaaac acgtggagcg cacgaaacgg cttggcgtta tgggcagcct tggcggtttt 631321 ggcggcatgt ttgacctgtc tgagctttct tatcaaaaac cagttctcat ttcgggaacg 631381 gacggtgtcg gcacaaaatt aaagctcgct ttttccatgg ataagcatga cacgattggc 631441 gtggatgctg ttgcaatgtg tgtcaatgac gtgctggcac aaggtgcaga gccgctgttt 631501 ttcctcgatt atttagcggt tggcaaagcg gacccagtga aaattgaaca gattgtacaa 631561 ggtgttgcgg aaggctgtga gcagtcaggt tcagccttag tcggcggtga aacggctgaa 631621 atgccggggc tctatacagc tgatgaatac gatattgccg gtttctcagt cggagtggca 631681 gaaaaggacg aaatcgtgac tggagaaaaa attgaagagg gccatctgtt gatcggcctc 631741 agctccagcg gccttcacag caacggcttt tcccttgtca gaaaagtgct tctggatgat 631801 gcggagctgg acctcgatac aacatatgag ccgtttgaac gcccgcttgg cgaggaattg 631861 cttgaaccga caaggattta cgtgaagcct gtgcttgccg cggtcaaaag cggaaaaatc 631921 gacggcatgg cgcacgtgac aggcggagga tttattgaaa atattccgcg tatgcttccg 631981 gaaggcttaa gtgcggaaat tgatcatggc tcatggccga tcccgccgat tttttctttc 632041 ttgcaagagt acggcaagct aaaggaagaa gacatgttca acgtctttaa tatgggtatc 632101 ggttttgttt tggcagtcaa agaagagcat ctgacagatg tgatcggaac gcttgaaagc 632161 catggcgaaa aagcctattt aatcgggcgt gtgaaaaaag gtgaaggcgt cacattcggc 632221 ggtgcggcac tttcatgaaa aagtttgcgg tatttgcatc aggaaacggt tcaaacttcg 632281 aagccatcgt cacgcgtttg aaggaggaga actgggatgc gtcagcagcg ctcctcgttt 632341 gcgacaaacc gcaggcgaaa gtcatcgaac gggcggaagc attccacatt ccatccttcg 632401 catttgagcc gaagtcttat gaaaacaagg ctgcatttga acaagccatc attgaacagc 632461 ttcgtcttca cgaggttgaa ttgattgctc ttgccggcta tatgaggctg atcggtgata 632521 cgctccttca agcatatggg ggaaaaatca ttaacattca cccatcgctt cttccggcgt 632581 ttcctggaat cgacgcagtc ggacaggcgt tccgggcggg tgtgaaggtg gccggaatca 632641 ccgtgcatta tgtcgatgaa ggaatggata caggtccgat catcgctcaa aaggcaatcg 632701 aaattgatga acatgataca ttggaaacaa tcgaacagcg aattcacaag cttgagcata 632761 aatggtatcc gagtgtgatt aaacagctat taggattaaa taacagaggt gaaaaggcat 632821 gaccattaaa cgtgcattaa tcagtgtttc agataaaaca aatctcgttc ctttcgtaaa 632881 agaactgaca gagcttggcg ttgaagtcat ctccacaggc ggaacgaaaa agcttcttca 632941 agaaaacggt gtggatgtga tcggaatttc tgaagtgaca ggctttcctg aaattatgga 633001 cggccggtta aaaaccctac acccgaatat tcacggcggc cttctggcgg ttcgcggcaa 633061 tgaagagcat atggcgcaga tcaatgaaca cgggattcag ccgattgacc tcgttgtcgt 633121 caacctctat ccatttaaag aaacgatttc taaagaagac gtcacgtatg aagaagcgat 633181 cgaaaatatc gacatcggcg gacctggcat gctgcgcgcg gcatcaaaga accatcagga 633241 tgtcacggtt atcgtcgatc cggccgatta cagcccagtg ctaaatcaaa tcaaagaaga 633301 aggcagcgta tctcttcaga aaaaacgcga gctcgcggca aaagtattcc gtcatactgc 633361 ggcatatgat gcactgatcg ctgactatct gacaaatgtt gtcggtgaaa aagaaccaga 633421 gcaattcact gtgacatttg agaaaaaaca atcgcttcgc tatggagaaa acccgcatca 633481 ggaagcaact ttctatcaaa cagctcttcc tgtcaaaggc tccattgcgc aagcagaaca 633541 gcttcacgga aaagagcttt cttacaacaa cattaaagac gcggatgctg cagttcaaat 633601 cgttcgtgaa ttcactgaac cggctgctgt tgctgtgaag catatgaacc cgtgcggcgt 633661 gggaacagga aaaacgatcg cagaagcgtt tgacagagcg tttgaagcgg ataaaacatc 633721 tatcttcggc ggcattatcg cgctgaaccg tgaagtggac aaggcaactg ccgaagcgct 633781 tcacaacatt ttcttagaaa tcatcattgc gccttcattc agccaagaag cgctcgacgt 633841 cctgactgcg aagaaaaatc tccgtctgct gacgcttgac gtatccgccg ctgttcaaaa 633901 ggaaaaacag ctgacatccg ttcaaggcgg gctgctgatt caagatttag atatgcacgg 633961 cttcgatgat gctgagatta gcattccgac aaaaagagag ccgaacgagc aagagtggga 634021 agacttgaag cttgcttgga aagtcgtgaa gcatgtgaaa tcaaatgcga ttgttctcgc 634081 gaaggacaac atgacagtcg gcgtgggagc aggccaaatg aaccgcgtcg gatcggcaaa 634141 aatcgcaatc gagcaagcag gggaaaaagc gaagggcagc gcgctcggtt cggatgcata 634201 tttcccaatg ccagatactg tcgaagaagc ggcaaaagcg ggcgttacag ccatcattca 634261 gccaggcgga tcgatccgag atgaggattc catcaaaaaa gcggatgaat acggcattgc 634321 catggtattc accggcatca gacacttcaa acattaaggg gatgaaaacg acgtgaatgt 634381 attaattatc ggtaaaggcg gaagagaaca tacgctggcg tggaaggcag cgcaaagcag 634441 cctcgtcgag aatgtatttg ccgctcccgg aaatgacggc atggcagctt ccgctcagct 634501 tgtaaacatt gaggaaagcg accacgcagg gcttgtctca tttgcaaaac aaaatcaggt 634561 cggcctgacc attgtcggcc ctgaggttcc tttaattgaa ggtctggtgg atgaattcga 634621 aaaagcgggc ttacatgtgt tcggtccgtc aaaagctgcg gcgatcatcg aaggaagcaa 634681 acagttcgct aaggatttaa tgaagaaata cgacattccg accgcagaat acgagacgtt 634741 tacatccttt gatgaggcga aggcatatgt gcaggaaaaa ggtgctccga ttgtgataaa 634801 agcagatgga cttgcagctg gaaaaggcgt tactgtggct atgacagagg aagaagcaat 634861 tgcgtgcttg catgactttc ttgaagatga aaagttcggt gatgcgagcg cgtccgttgt 634921 cattgaagaa tatctttctg gtgaagaatt ttctctaatg gcctttgtca aaggggaaaa 634981 ggtgtatccg atggtgattg cccaggatca caagcgggcg tttgacggag acaaaggccc 635041 gaatacaggc ggcatgggcg cctactcgcc agttccgcaa atttcggaag aaacggtccg 635101 ccatgctgta gaaacgatcg ttaagccggc tgcaaaagca atggtacaag aaggccgttc 635161 cttcactggc gttttgtacg ctggattgat gcttactgaa aacggctcga aggtcattga 635221 atttaatgcc cgtttcggcg atccggaaac acaggtcgtg cttccgcgca tggaatctga 635281 tctggtacag gtgcttcttg atcttttaga tgataaggaa gttgacttaa gatggaagga 635341 taccgcggca gtgagtgttg tgcttgcatc agaagggtat ccggaaagct atgcaaaagg 635401 cacgccgatc ggcagccttg cagcagaaac tgagcaggtc gtggtcttcc atgccggaac 635461 gaaagcagaa ggtggagagt tcgttacaaa cggggggcgc gtcgccaatg tgacggcttt 635521 tgatgaaacg tttgaagcgg ctagagaccg agtgtacaaa gcggttgatg aaattttcaa 635581 accgggactc tttttcagaa aagacattgg ggcacgcgct ttaaaggctg cccaaaaata 635641 agtgaggaaa acccgcagaa tagctgcggg ttttttgtta tcaaaaagcg ggatggcagc 635701 tagaagaaga aagcacaacg agcgtggttg gttttccatg ggccatcgag gtgtcaataa 635761 aatcctcaag cgtatgtacc gattcagtca cgacctttgt cacatagctg tacatccccg 635821 tgatgcggtg gttttctgct acatcaggat gcgatgttgc aaaggcggcg tagtgcttgc 635881 agcttttcgg ctccatgaga ataaaagcgg tgacatgctt gtttagtttt tcgtaacaga 635941 tattcgcgct gtagccggta atcactcctt tgtcttccag cttcctgaca cgctccgccg 636001 cgcttggcga gctgagtccg acaagctttc ccagctcaac catcgttaat ctgccgtttc 636061 gctgcaaatg cgagagaatc tgaaggtctg tatcgtccat ttgtctggct cctttacata 636121 tttaggcgaa tgaatgaaaa ttcctttgat cgtaaggtaa tgctgttgat ttaacttcat 636181 tgtagcatat ggatgccgtc ttattttttc tataataaag ccatcaatca gagagggggc 636241 atcatgttgc cagaattgca gcgctctatt acttggatac aagggacggc gttaacgatt 636301 ggggcggttt taggatgcgg gatattaatc ctgccgtctg tcaccgcgga cacggccggc 636361 cccgcttctt tatttgtttg ggtgttcatg tccttcttat ccttttttct tgtcggcacg 636421 ctggcccggc ttgtgaaaat agcgcctagc gcgggaggaa tcacggctta tgtgcagctg 636481 gcctttcaga aaaaagccgg ggctattttg ggctggatca tgttagggtc cgttccgatc 636541 ggcgttccca tcatcgcttt gactggcgcg cattacgtca gttacatcac agaggcggcc 636601 gattggcaga ttacattgat tgctggttgc atgctggcta tatctatttt gcttcatatg 636661 agagggattc aactatcagc aaacattagt acactcgtta tatgtgtcat cgtatttctg 636721 cttgtcactt ctattgctgt gtcattgcca cacgtcacga tagcagaatt caagccgttt 636781 cttccgcatg gctggtctgc cgctggatct gtttctgtta tgattttttt ctcttttgta 636841 ggctgggaaa tgattacccc gttggctgag gaatttcatc gtcctgaaaa agatgtcccg 636901 ctcagcttgt ttttggcagc gtcttgtgtg gcggggctgt atatcatgct gtcatttgtg 636961 accgtgggta ctcattcata tggagagaat ggagaaattg catcgcttgc catgctcatt 637021 tcaaaaggag caggagaaag cggtgtatat gtcacggtat gtttagcgct gtttattaca 637081 ttcgccacca tccatgccaa tattgccggt ttttcaagaa tggtgtacgc attggcgaga 637141 gaggggcaca tacccgtatt ttttggaaaa ctcagtgcga caaaacgtac gcctattcgc 637201 gttttgacag cgatggccgc agtgtttggc ttagtgcttg cagcgcatgg tctgtttcaa 637261 atcgatttga cgactctgtt gaaagggccg agcgcggctt ttatcgcatc ttacatatgt 637321 acaatggcgg cagcactgaa actgctgggc aggagagata taggctggtg gatggcgctc 637381 ggggcatttg tggcgtgcgc ggtgatttat tcattcagcg gctgggcact gctttatccg 637441 gcagtgctgg cagctgcagg atatttctat atgaaaacaa agggtgggca taaaaaaaag 637501 cttgatcacg ttttgtgatc aagcttttcc atttatccgt tttgatgctc gttatttcca 637561 gaatcgctgt gttgaaacat gtaggtcaca ggacagaagc gcaagattcc cgaacccgct 637621 ttcatggccc ccataaagat gtaaaagaga tgcattctgc accaaggttt tttcgtaaac 637681 tttgcactgg cggctgacat aatcgtcaat ccgcaggcga ttctgaacac ggcattgatg 637741 agactgatgt ttggcttcaa ggaaatccgc tccttttact taaaaaagtt ttttaatcga 637801 accttcaaaa atttgtaacg tttttatcgt gcgtgatgag gaaggatgtg ataccatgag 637861 tctaatacat gtaaaggaga gtatgtgaat gtccgaacgc acctttaact ggaaaaacaa 637921 agacatcagg gcacaggttg atgttgtaga ctcaaagctg cttccaacgc tccttttacg 637981 gaatgctctc gtcttaaatc catatgtaaa acaatggctg aaaaaaaaca tttggattta 638041 tcaggaccgc attgtttatg tgggtcatga acttccgaat agagccgaag aaattcatac 638101 gattgattgt gaaggaaaat acattgtgcc aggttatatt gaaccgcacg cacatccttt 638161 tcaaatatat aatccccaaa cactggcgga atatgtgtct caatacggaa caacgacatt 638221 cgtgaatgat aacttatttt tgcttttgca aagcggaaaa aagaaagcgc ttacgatttt 638281 gaatgaactc aaaaagcagc ctgtccagta tttttggtgg tcacgctatg acctccagac 638341 cgaggttctg aacgaggacc acgtccttcc atttgacgtc agaaaacagt ggattgaaca 638401 tccggatgtg attcaaggcg gagaaatgac cggatggcct cgcctggtag atggtgatga 638461 tttaatgctc cactgtatgc aagctacaaa gaaacagaga aaacgtattg aagggcattt 638521 tcccggcgct tctgataaaa cgcttacaaa aatgaagctg ttcggtgcgg attgtgatca 638581 tgaagcgatg acaggtgatg aagtgatgag aaggctggaa ctgggctatt atgtttccct 638641 tcggaactct tccattcgcc ccgatgtaag aaaaatcttg caagagctgc atgagaaggg 638701 cttccgctat tatgaccact tcttttacac gacagatggc gcaaccccga atttctataa 638761 aggcggcatg acaaacgagc tgattcgcat tgcgttagaa gaaggcgtac ctgcaatcga 638821 cgcctacaat atggcatcat ttaatatcgc aaagtattac caaatggatg attatttagg 638881 agttgtcgga ccgggcagac tggcatcgct aaacatactg gaagatccgt taaatccgaa 638941 tccagtgact gttctgtcaa aagggaccat tctgcgtgaa aacggctgtg atttgaaggc 639001 gtttacaaag acggactggc acaaaggcgg tcttgtcccg cttgagcttt catatgatat 639061 gacgatggat gacttgcagt tttctatgcc gatgggcgtg aaaatgcgga atgcggttat 639121 tatggagcca tatatgattg agatcgacaa ttcgatggaa cagctctcgt ttgaccatga 639181 tgaaagttat ttgacgatgc tcgacagaca cgggaaatgg cgcgtcaata cgatgataaa 639241 agggtttgcc tcaagcgtgc agggatttgt aagctccttt acgacgacgg gcgacattgt 639301 cgcgattgga aaaaataaag cggatatgct gctcgctttc gcccgcatga aagaaatcgg 639361 aggaggaatt gttttagcgg agaacggaaa cattctgcat gaaatcccgc ttgcgctgtg 639421 cggctgcgcc tcttcggaag cgtatgaaga cgtgcttgag aaggaacaaa agctgagaga 639481 tcttttgact gaaagaggct atgagttttg cgatcctatc tatacgctgc tctttttgca 639541 aagtacgcac cttccgtata tacgcattac gccaagagga atattcgacg tcatgaaaaa 639601 aactgtactc tttccatcga taatgcgtta aaatataaaa gagcagggag ccgacatatg 639661 aaaaaatgga tgacagtttg cgcgctgtgt ttcgtgtttt ttctgctggt atcctgccag 639721 cagaaggatg ctgtcccgga tactgcaaag aagctgaaag ctcctttaac ggggctaaag 639781 actgaacaga aagtgactga acgccgccct gttgctgttg tggtgaacaa tcacccgaag 639841 gcgaggccgc agtcgggtct gtctaaagcc gacattgtca tagaagcgct agccgaaggg 639901 caaatcacaa gatttctggc cattttccaa agccagatgc ctgaaactgt cggacctgtg 639961 cggagcgcgc gggaatattt cgtcactctc agcaatggct ttgacagcat atttgtccat 640021 cacggctgga gtcccggcgc caaaaagcag ctggaatccg gagctgccga ttatatgaac 640081 ggattggatt ttgacggaag cttattttgg agagctgatt tcagcaaacc gccccacaat 640141 tcctatacgt cttatgatta cataaaaaag gcggcagaac aaaagggtta taagctgaag 640201 caggaaacaa atccgctgct gtttcaaaca tcagatgcaa aacctgcaaa tgaatcttac 640261 aatgttcggg tagattatgg aacaaataac gttacaaatc ttgtcgaata caactatgat 640321 aaaaaagctg aattttatac aagaagctct gatggtgtca taacgacaga ccgggaaacc 640381 ggaaagccgg ttgcaatgca aaatattttc attgttgaag ccagccatca tattattgat 640441 caagatggaa ggcgggacat cgacttggaa tcaggaggaa aaggtctgtt gtttcagcac 640501 ggaaacgtca ttgaaacaga ctggaaacaa gtgaatggca gaattgtgcc ggtaaaagac 640561 ggcaagtggc ttccgtttgt gccaggaaag acttggatca atatcgtacc tgatcttgat 640621 gcggcttcca ttagtaaagg agaaggtgtg taacgatgca aatcgataaa ttacgcggca 640681 aagagctgga ccagttattt aactcgatct tatcgctgaa agacctggag gaatgttacc 640741 gattcttcga tgatctatgc acaattaacg aaattcaatc gctggctcag cgccttgaag 640801 tggcgcgcat gcttcgcgaa ggaaacacgt atcataagat tgaaacagaa acaggcgctt 640861 ccacggctac gatttcccgt gtgaaacgct gcttaaatta cggaaatgac gcttatgaaa 640921 tggcgcttga ccgtgtgaag gagacggaaa cagagtcttc ttccaaataa aaaaccgccc 640981 tgccgtctgg caagggcggt ttctttatga aacaaattga tggatcaggt tgtcgatatt 641041 gatgatactg ccatcctctt tccgatagac aacatgctcc ttggaaaaat gaatcggcga 641101 attaatccct gctgcggctg caaggttaaa tagtccctcg cgcaatgaaa taacgtagtt 641161 gcagacacga tgctgttttt cctcaacgct cagtgctttt tgcaatttcg gatctgtcgt 641221 cgccacacct gccggacagg tgttggtgtg gcagacgaga gcgcggatgc agccaacgga 641281 aaacatcatg ccgcgtgcga tgttaacaaa gtcagcgccg agggctaagg cgaccgcgat 641341 tttatcagga gtcaggagct ttccggaagc aaagattttc agctggctgc gcaagccgta 641401 ctgtttaaga agcgtgtcca caataggcag cgctgtcata atcggaaggc cgactgtatc 641461 cgcgagctcg taaaaggaag ctccggtacc gccttcactt ccgtcgatcg tgataaaatc 641521 cggatgcttt ccgcttttct gcatatgaga gaaaagctca tgcaattctt caggatgccc 641581 tgcgaccagt ttgatgccga ctggcttttg tccgacatct ctaagttttt caataaagtc 641641 gagcatttca ggagggtttg agaattcata aaagcggttc gggctgtcaa tcgactttcc 641701 aggttcgaca ttccgaatgt ctgccacttc ctctgatact ttggcgccgt ccacatggcc 641761 gccgcgggtt ttcgctcctt gtgccagctt tagctcaaac gctttaatct ggtcaatcct 641821 gctttttctt ttaaattcct cccacgaaaa ttccccgttt cttttgcgca cgccgaatag 641881 gcccggtccg atttggcaaa tgatatcggc gccgcccttt aagtgatatt cagacaatcc 641941 cccttcacct gtattcatcc aggtgccgcc tgccagatgg agcccttttg agagcgccgt 642001 aacagcccgt tctccaagag aaccgtagct catggcagac tggccgacta agcccttcac 642061 ataaaatggc ttctcgcatg tatgctcgcc aatcacctgt acatcatcag gatggagaaa 642121 atacgggtct gccttgatat gttcggcatg ctccttgcgt ttgaacagat tgtcagcatc 642181 cattttatag atttgggttt caatttttgg cgtttgattt acatgcattt cttccctttg 642241 ttttggaaac atagcgttac ggatataata gccaggttta tcaaaatctc ttacagatcc 642301 aaagcccatc attctgcttt tgtatttgcc ggagatgacg gtttgctcat attcctttcg 642361 tgaaaatggc tgctcttcat tgtcattgct gtataaatac tgtctgagct ccggcccgat 642421 tttttcaagg atataccgaa accttccgat gacgggatag ttgcgaagaa ttgagtgctc 642481 ctgctgtttt tcatccttta tgtagatcca ggcaaacaag acgatcggga tagcgatgat 642541 cccaatgata aatgcgatga gtgctattat gatggtttcc atctctcagc ctcccttttt 642601 atgtaaccat ttccacagta gaacactttc caaacaatag cagaaggaat ctggtgaaaa 642661 atgtgtgctc ctgccgatac aggactcacc atgcaggtac tgccatatgc tctctttttt 642721 tatgaaaaaa gaatcaaaac acctttttca gtgaataacg agattaacgg ctttttccgt 642781 ttttccgcgc tatgtgaatt tgttataatg tttaaatggt aacaaacgaa tggaggaacg 642841 tatgacgtgt acgatgtaac ggagtggaag catgtcttta aactcgatcc aaataaagat 642901 ttgcctgacg aacagctgga gattctttgc gaatcaggaa cggatgcggt cattatcgga 642961 ggaagcgatg gtgtgacaga ggataatgtc ctgcggatga tgtctaaggt aagacggttt 643021 ttggtgccgt gtgtcctaga ggtatcagcg attgaagcga ttgttcccgg ctttgactta 643081 tattttattc cgagtgtatt aaacagcaaa aacgcggatt ggattgtcgg aatgcaccag 643141 aaagccatga aggaatacgg agaactgatg tctatggaag aaatcgtggc ggagggctac 643201 tgcatcgcaa atccagattg caaagccgcg gcactgactg aagcggacgc cgatctgaat 643261 atggatgata ttgtcgccta tgcgcgtgtg tcggagctgc tgcaactgcc gattttttat 643321 ttagaataca gcggcgtgct tggagacata gaagctgtca agaaaacgaa ggctgtattg 643381 gaaacgtcca ccttgtttta cggcggcggc atcaaggatg cggaaacggc caagcagtac 643441 gcagagcatg cggacgtgat cgttgtaggc aatgcggtgt atgaagattt tgacagggct 643501 ttgaaaacag tagcggctgt gaaaggcgag tagtaaattg tacggatttg gtttatgata 643561 gaacgtatgt tttgtatagg cgggtgaaca aattttgaat tatattagca atcaattact 643621 aagcggttta aaccccgttc agcaggaagc agtcaaaaca acggacgggc ctcttttgct 643681 gatggcggga gcgggtagcg gaaagacgcg tgtcctgacc catagaattg cttatttaat 643741 ggcagaaaag catgtggcgc cgtggaacat tctggcgatc acatttacaa ataaagcggc 643801 acgcgaaatg aaagaacgtg tggaaagcat cctcggaccc ggcgcggacg atatctggat 643861 ctccacattc cacagcatgt gcgtgcggat cttgcgcaga gatatcgacc ggattgggat 643921 caaccgaaat ttctccatcc ttgatacggc tgaccagctt tcagtgatca aggggatttt 643981 gaaggagcgc aatcttgatc cgaagaagtt tgacccgaga agcatcctcg gcacgatcag 644041 cagtgcaaaa aacgaattga ccgaaccgga ggaattctct aaagttgctg gcggctacta 644101 cgatcaggtg gtcagcgatg tatatgctga ttatcagaag aagctattga aaaaccagtc 644161 gctcgatttc gacgatttaa ttatgacgac gattaaactg tttgacagag tgcctgaagt 644221 gcttgaattt tatcagcgca aattccagta catccacgtt gatgagtatc aggatacgaa 644281 cagggcacaa tacatgctcg ttaagcagct tgccgagcgt ttccagaacc tttgcgttgt 644341 gggggattct gatcagtcaa tctacagatg gcgcggcgcg gatatcacca acattctttc 644401 atttgaaaaa gattatccga atgcaagcgt gattttgcta gaacaaaact atcgttcaac 644461 gaaacggatt ttgcgcgcgg ctaacgaggt cattaaaaac aactctaacc gcaaaccgaa 644521 aaatttgtgg acggaaaatg atgaaggcat caagatttcc tattatcgcg gtgataatga 644581 gttcggtgaa ggacagtttg tggccggcaa aattcatcag cttcacagca caggcaagcg 644641 gaagctgtcg gatatcgcca tattataccg gacaaacgcg cagtcccgtg tgattgagga 644701 aacgcttctc aaagcgggct tgaactataa cattgtcggc ggcacaaagt tctatgacag 644761 aaaagaaatt aaagacattc ttgcgtacct gcgcctcgta tccaatccgg atgacgatat 644821 cagtttcacg cgcattgtca atgtgccgaa gcgcggagtc ggcgcgacat cacttgaaaa 644881 aatcgcttcg tatgcggcca taaacggctt gtcctttttc caagcgattc agcaggttga 644941 ttttatcggc gtcagtgcca aagcggcaaa cgcgcttgac agctttagac agatgattga 645001 aaacctgacc aatatgcagg attacttatc cattacagag ctgacagaag aaattcttga 645061 taagacggaa tacagagaaa tgctgaaggc tgagaaatcg atcgaagccc aaagccgttt 645121 agaaaatatc gacgagttcc tgtctgttac gaaaaacttt gaacagaaaa gtgaagacaa 645181 gacactcgtt gcgttcctga cagacttggc attgatcgca gatattgatc agctcgatca 645241 gaaggaggaa gagtcaggcg gcaaggatgc gatcaccctg atgacactgc acgccgcgaa 645301 aggactggag tttccggttg ttttcttgat ggggcttgaa gaaggcgtct tcccgcatag 645361 ccgttcactc atggaggaag cggaaatgga agaagaacgc cgccttgcgt acgttgggat 645421 tacaagggcg gaacaggagc tttatctgac caatgctaaa atgcgcacct tgtttggccg 645481 gacaaatatg aacccggaat ctcgcttcat tgctgaaata ccggatgatt tattggaaaa 645541 cctaaatgag aaaaaagaaa caagagcgac gtctgcgaga aaaatgcagc cgagacgcgg 645601 ccctgtttca cgcccggtat cctacgccag caaaacaggc ggcgacacct tgaactgggc 645661 agtcggagat aaggcgggcc ataaaaaatg gggaacagga actgtcgtca gcgtgaaagg 645721 cgaaggagaa gggacagagc ttgatattgc cttcccgagc cctgtcggcg tgaaacgcct 645781 gttagcagca tttgctccta ttgaaaagca gtaattgaag aggaaaggaa gaagcagatg 645841 gacaaagaaa cagcgaagca gcgggcagaa gaactgcgcc gcaccatcaa caagtatagc 645901 tatgaatatt acaccttaga tgaaccgagc gtcccagatg ccgaatacga cagattgatg 645961 caggagctga tcgcgatcga ggaggagcac ccagacctca gaacgcctga ctctcctacg 646021 cagcgcgtcg gcggagccgt gcttgaagcg tttcagaaag tcacccacgg cacaccgatg 646081 ctcagtctgg gcaacgcctt taatgctgat gatcttcgtg atttcgaccg ccgtgtgcgc 646141 cagtccgtcg gcgacgatgt ggcgtataat gtggagctga aaatagacgg tcttgctgtt 646201 tctctccgtt atgaagacgg ctattttgtc agaggggcca caagaggtga cgggacgacg 646261 ggagaggata tcacggagaa tctgaagacg atccgcaata tcccccttaa aatgaaccgt 646321 gagctgtcga tcgaagtgcg cggcgaggcg tatatgccga agcgttcgtt tgaagcactc 646381 aatgaggaac ggattaaaaa tgaggaagaa ccgttcgcca atccgcgaaa tgccgcggcg 646441 ggatctctca gacagctcga tccgaaaatt gcagcgaaac gaaacctcga tatcttcgtc 646501 tacagtatag cggagcttga cgagatgggt gtagagacgc aaagccaagg gcttgatttt 646561 ctcgacgaac tcggatttaa aacgaatcag gaacgaaaaa aatgcggcag catagaagaa 646621 gtcattacgc tgatcgatga gcttcaggcg aagcgcgcgg acctgccgta cgaaatagac 646681 ggcattgtca ttaaagtcga ttctctcgat caacaggagg agctcggttt tacggcgaaa 646741 agcccgcgct gggccatcgc gtataagttt cctgctgaag aggtcgtgac gaagcttctc 646801 gatatcgaat taaatgtcgg cagaacgggt gtgattacgc cgactgcgat tcttgagccg 646861 gtaaaagttg ccggcacaac ggtctcaaga gcatcccttc ataacgaaga tttaattaaa 646921 gagaaggaca ttcggatttt ggataaggtt gtcgtcaaaa aagcgggcga tatcatcccg 646981 gaagttgtga atgtcctcgt tgaccagcgc acaggagaag aaaaggaatt cagcatgccg 647041 acggaatgtc ctgaatgcgg cagtgaactc gtccggatcg aaggagaagt ggcgcttcgc 647101 tgcattaacc ctgaatgtcc ggcgcaaatc cgggaagggc ttatccattt cgtttcccgg 647161 aatgccatga acattgatgg gctcggcgaa cgagtgatca cacagctgtt tgaggaaaac 647221 cttgtccgca atgtggcaga tttatataag ctgacgaagg aacgagtcat ccagctcgag 647281 cgcatgggcg aaaagtccac tgaaaacctg atcagctcca tccaaaaatc aaaagaaaat 647341 tcgttagagc gcctgctgtt tgggcttggc atccgtttta tcggatcaaa ggccgcaaag 647401 acgcttgcca tgcattttga aagcttggag aacctgaaaa aagcctctaa agaggaactt 647461 ctcgcggtag atgaaatcgg tgaaaaaatg gctgatgctg tgatcaccta ttttcataaa 647521 gaagaaatgc ttgaactctt gaatgaactt caggagctgg gcgtaaacac gctctacaaa 647581 ggcccgaaaa aagtaaaagc agaggacagc gactcttact ttgctggtaa aacaattgtt 647641 ctgacaggaa agctggaaga gctgtcaaga aacgaagcca aagcgcaaat cgaagcgctg 647701 ggcggaaagc tgactggaag cgtcagcaaa aacacagact tagtcatcgc cggagaagcg 647761 gcgggaagca agctgacaaa agcacaagag ctgaacattg aagtgtggaa tgaagaacag 647821 ttaatgggag agctaaagaa ataagaggag tgttttctat tgaaaaagac gttggcattg 647881 gcggcaacgg cggcagtatt aatgctgtct gcctgctcgt caggtttcgg gggggagaag 647941 gaggaagaga ttacgcaaaa gacggcgaaa tcgtcagaaa aagcgattgt cccgaaatat 648001 aatatctctg actcctatta caaaatggtg ctgccgttta aggcaggcaa agcgcgcggc 648061 ttaacaacgg aacagctgaa tacaaggctg gacattgacg aatttgaaac agggctgatg 648121 cgccttgccc aagattcttt ctcaactgac gattatctgt tccaagaagg acaatattta 648181 gatgaggata cagtattaag ctggctggca cggaaaaaaa cgggctctga tttgaaaaaa 648241 gccgaaaaag aagataagaa cttcaaaaat gaaggcttga acccggcgct cccgagttct 648301 ggttcaacag aagaaaagaa cgaaagcagc ccaatttatt tagcatccat gcttgagcac 648361 gattatttag tcagaaaaga caagaattct atccagcttg gcggcgtcat gatcggactg 648421 gcgttaaact cagtgtatta ctatcgtgaa aaaactggcg acccgcaaaa agaagtggag 648481 attaaagaca gcacgcttcg ccagcaggga gaaaaaattg cacaggaggt tattaaccgc 648541 ctccgcaaaa aagataactt gaagaatgtg ccgattaccg tggcgctcta caagcaggcg 648601 tcaaaaacat cgattgtgcc ggggaacttc atcgccaaaa cagaggtcaa agcaggctct 648661 actgatatct caaattggga tgacatcaat gaaaaatatg tattctatcc ggcggataca 648721 accacagcag aaaagtaccc ggatgacacc gaggtcttta agcggttcaa aaactcaatt 648781 gaagaatatt tcccgaacta tacaggcgtt gtcggtacag cgctgtatga aaatgatgaa 648841 atgaagaaaa tgaagattga cataccaatg caattctacg gaaaaagtga agttgtcgcg 648901 tttacccagt tcttaacggg tgaagtgatg gactactact ctaagagctc agttgatgtc 648961 gaagtcaata tcacgtcctc agacggacag gaagcggtca ttatccgcaa tgccggagat 649021 aaagagccga ctgttcacat ttatgactga tagaaaaccc ttgtgccata ttggcacaag 649081 ggtttttatg ttacaattaa caggaaaagg gaaaatattt tcacttctgc cgaaacacaa 649141 atcaagggga ggtatgttga tgctggaaat cgtgtgaaaa caatcattat caaatctata 649201 gcaatgaaag gatgttagac gtgcataaag atatcaaaaa aatatttcat gaagagcagg 649261 ttttggcaga agctgcagcg agatacggtt tctcaaaaga tcaggtgcgt tttctggctg 649321 atgcggaaaa ctatgtatat gaatgtatga aagacaatca accttatatt ttaaagatta 649381 cccatacgat tcggagatct tctgattata tgatgggaga gatggaatgg ctccgtcacc 649441 ttgcaatagg gggaatttca gtagccaaac cgctcccgtc gctgaacgga aaagacgtag 649501 aagcagtgcc ggacggaaac ggcgggtcat ttttattgag agtgtatgag aaagcgccgg 649561 ggcaaaaagt ggatgaatcg gactggaatg aaacgctatt ttatgagctt ggcagataca 649621 caggcagcat gcacagcctg acaaaaagct acaaattgag caatcccgct ttcaaaagac 649681 aggaatggga tgaagaggag caattaaagc tgagaaaata tgtgcctgaa gatcagataa 649741 aggtgtttca gcaagccgat tctttgatga atgaactgcg gaggctcccg aaaagccagg 649801 acaactacgg cttggtgcat gcggatctgc accatggcaa ttttaactgg gatcatggca 649861 aaatcacggc atttgatttt gatgatatcg gctacaactg gtttgttaac gatattagca 649921 ttcttctcta caatgtcctg tggtatcctg ttgtgccata tgatgataaa gctgcgttta 649981 cagaagaatt tatgacgcat tttatgaaag ggtactggga ggaaaatgag cttgaccctg 650041 catggctgat gataatacct gatttcctcc gccttcgcca tatgctgatt tacggattgc 650101 tgcatcagat gtttgacctt aacacaatag gagaagagga aaaagaaatg ctggccggtt 650161 tcagaagaga tatagagaat ggcacgccga ttacagcatt tgatttttca gcactggtgt 650221 agatagaaaa agccaatggg attccagtcc cattggcttt tataatgtat cacacttcac 650281 gccgactacg ccttcaatgg ctttaatgtc atagtagaca tcggtcgtgt atctgttttt 650341 atggacgcgg accttcactt ccataattgg aaaatccttt tcgcctaggt cgtcgatccg 650401 aacggagtgt gctttgatat ctcttctttt catttctttt aaaatctctg tcattttgtc 650461 tttatcagaa agtgacattc tgatgcggat gtctttttcc tgcaggcggt cggggccgat 650521 ttttctgacc acccatggga gaaattccac actgatcagg atgaacagaa gactggcaaa 650581 cgcttcttta taaaaaccgg ctcccgtagc aagcccgagc cccgctgccc cccagatcat 650641 ggccgatgtc gtcaggccgg aaatgacatc attgcttttt cgcaggatga caccggcgcc 650701 gataaacccg acgccggaga tgatttgtgc cggcagacga agcggatcca tcatgatgcg 650761 gtagtattta gggaaatgat atgccgcatt aatactgacg atcgtcagca tgcatgagct 650821 gactgcgatg acaatacagg tttttaatcc gagcggctta ttttttaatt cgcgttcaag 650881 cccgatgacc atgccaatca atgtggcaat gcccaatttc aataaaatat caggatcaat 650941 ataccagctc aacagcaaac ttcccccttc tctatggtgt ttttaaataa atatgatttt 651001 ctcacagtat ttatagcaaa acaagagcac aaaagccacc aagctgcgct tgatggctta 651061 ttgcttactt tttgcgtttt aacagctttt ccatgacacc gaataatcgg taagaggctt 651121 ttgcaggacg ttttgtgatc atgctgacaa tgatgccggc aatcatactg agaataaacc 651181 cagggatgat ttcgtacaca ccggttgatt ttgccaggcc ggttgtaatc cagatcaaca 651241 cggtcgcagc cccgacaatc atggcagcaa gcgcgcccca ttcgttcatt cgtttccaat 651301 acagactgag cagaatcgca ggcccgaaag ctgaaccgaa gccggcccaa gcgtatccga 651361 ccaaatcaag aatggtgctg ttcgggttca atgacaagag taccgcgata acggcaatga 651421 ctaagacgga caatcgcccg atcatgacca attctttatc agaagctttt cgtctgaaaa 651481 atgaccggta taaatcctct gttacagcac ttgctgtgac caagagctgt gaggaaatcg 651541 aactcatgat ggcagccaaa atagctgaca ataagaaccc tgtaattaat gggtggaaca 651601 agattttaga gaagataatg aaaatcatct ccggatcttt tacagcaact ccgaatttat 651661 gggcgtatgc aacaccgatt aaacccgtca gcacggaacc tagaactgta atgatcatcc 651721 agctcatgcc gattcggcgt gcaggtttta aatctttaat gtctttaatg gccataaatc 651781 ggacgatgat atgaggctgg ccgtagtagc ccaaccccca ggctaaatag gaaataatgc 651841 taatgacgct cgcgccttta aaaatatcca ataaatgtgg attaacagcg tcgatttcat 651901 ggaaagtcgg agcaacgccg cccacatggg taaaagcaac gatcggcaca agcactagtg 651961 ctgcaaacat gatcgcaccc tgcacgaagt cagtcagact gacagcaagg aaaccgccaa 652021 acagtgtgta taacacgaca actgcggtgg tcagaaacag gcctaatttg taatccgcac 652081 caaaagcaga ttcaaacagc cgtccgccag ataccatacc ggaagaggta tacaatgtga 652141 aaaagatcat gatgatcaat gcagatacga ttttcagcag tgatgaagaa tgctggaatc 652201 gtttatcaaa gaaatcagga attgtaatcg catcatctgc cgcttctgta taagcacgca 652261 gccttggagc cagcagcaag taatttgagt acgccccgat tgtaagacct aaagcaagcc 652321 ataaggtgga cagccctgtc gcaaacatcg cgccgggaac acccatcagc atccatccgc 652381 tcatatcggc cgcgccggca gacaaagcag taacgaatgg tccgaggcct cttcctccaa 652441 gcatgtaatc attgatgtca gtggttttct tgaatgcata ccagccgatt aacagcatgg 652501 caataaagta aattcctaaa gatataataa tttcaatact cacgttttac cctctcttca 652561 tttctaataa tgttgcatca cctctcaaat tgatggtgcc agttaagcag cctggcgtaa 652621 gtgcaaaaca aaagaaattc ttttgcgggt gcacttggta acttaaccta acaaagtatt 652681 cccggccatt caagcgatga aacattgatc ataagctgga aataccgttg caaacctaga 652741 agggaataaa gaataaaacg ctttcaaaaa ataattaaag taaaaatatt cagaaaaata 652801 tttcgtttct ccttctcctc attttagtat aaaatatata gggtattgtt tcgaaaacac 652861 aggcctgtct caaggcgttt tgttgcttta aagggcttgt ttttgatatg atcagtatta 652921 tatgacttaa cggagaaata tgtggaggtg gatcatatgt cacgaatttc aatagaagaa 652981 gtaaagcacg ttgcgcacct tgcaagactt gcgattactg aagaagaagc aaaaatgttc 653041 actgaacagc tcgacagtat catttcattt gccgaggagc ttaatgaggt taacacagac 653101 aatgtggagc ctacaactca cgtgctgaaa atgaaaaatg tcatgagaga agatgaagcg 653161 ggtaaaggtc ttccggttga ggatgtcatg aaaaatgcgc ctgaccataa agacggctat 653221 attcgtgtgc catcaattct ggactaaagg agggacacaa gaatgtcatt atttgatcat 653281 aaaatcacag aattaaaaca gctcatacat aaaaaagaga ttaagatttc tgatctggtt 653341 gatgaatctt ataaacgcat ccaagcggtt gatgataagg tacaagcctt tttggcatta 653401 gatgaagaaa gagcgcgcgc atacgcgaag gagcttgatg aggcggttga cggccgttct 653461 gagcacggtc ttcttttcgg tatgccgatc ggcgtaaaag ataatatcgt aacaaaaggg 653521 ctgcgcacaa catgctccag caaaattctc gaaaactttg atccgattta cgatgctact 653581 gtcgttcagc gccttcaaga cgctgaagcg gtcacaatcg gaaaactgaa catggacgaa 653641 ttcgccatgg ggtcatctac agaaaactca gcttacaagc tgacgaaaaa cccttggaac 653701 ctggatacag ttcccggcgg ttcaagcggc ggatctgcag ctgcggttgc tgcgggagaa 653761 gttccgtttt ctcttggatc tgacacaggc ggctccatcc gtcagccggc atctttctgc 653821 ggcgttgtcg gattaaaacc tacatacgga cgtgtatctc gttacggcct ggtcgcattt 653881 gcgtcttcat tggaccaaat cggaccgatt acacgtacgg ttgaggataa cgcgttttta 653941 cttcaagcga tttccggcgt agacaaaatg gactctacga gtgcaaatgt ggacgtgcct 654001 gattttcttt cttcattaac tggcgacatc aaaggactga aaatcgccgt tccgaaagaa 654061 taccttggtg aaggtgtcgg caaagaagcg agagaatctg tcttggcagc gctgaaagtc 654121 cttgaaggtc tcggcgctac atgggaagaa gtgtctcttc cgcacagtaa atacgcgctt 654181 gcgacatatt acctgctgtc atcttctgaa gcgtcagcga accttgcacg ctttgacggc 654241 atccgctacg gctaccgcac agacaacgcg gataacctga tcgaccttta caagcaaacg 654301 cgcgctgaag gtttcggaaa tgaagtcaaa cgccgcatca tgctcggaac gtttgcttta 654361 agctcaggct actacgatgc gtactacaaa aaagcgcaaa aagtgcgtac gttgattaag 654421 aaggatttcg aggacgtatt tgaaaaatat gatgttattg ttggaccgac tacaccgaca 654481 cctgcgttta aaatcggtga aaacacgaag gatccgctca caatgtacgc aaacgatatc 654541 ttaacgattc cggtcaacct tgccggcgta ccgggaatca gtgtgccatg cggattagca 654601 gacggacttc cgctcggcct gcaaatcatc ggaaaacact ttgatgaaag cactgtatac 654661 cgcgttgctc atgcatttga acaagcaaca gaccatcata aagcaaaacc tgaactgtaa 654721 ggggtgaaaa gaattgaact ttgaaacggt aatcggactt gaagtccacg ttgagttaaa 654781 aacaaaatca aaaattttct caagctctcc aacgccattc ggcgcggagg cgaatacgca 654841 gacaagcgtt attgacctcg gatatccggg cgtcctgcct gttctgaaca aagaagccgt 654901 tgaattcgca atgaaagccg ctatggcgct caactgtgag atcgcaacgg atacgaagtt 654961 tgaccgcaaa aactatttct atcctgacaa cccgaaagcg tatcagattt ctcaatttga 655021 taagccaatc ggcgaaaacg gctggatcga aattgaagtc ggcggcaaaa caaaacgcat 655081 cggcatcacg cgccttcatc ttgaagagga tgccggaaaa ctgacgcata cgggcgacgg 655141 ctattctctt gttgacttca accgtcaagg aacgccgctt gttgagatcg tatcagagcc 655201 ggacatccgc acgccggaag aagcgtacgc atatcttgaa aagctgaaat ccatcatcca 655261 atatacaggc gtttctgact gtaaaatgga agaaggctca cttcgctgtg acgccaatat 655321 ctctcttcgt ccgatcggcc aagaggaatt cggcacaaaa acagaattga aaaacttgaa 655381 ctcctttgcg tttgttcaaa aaggccttga gcatgaagaa aaacgccagg agcaggttct 655441 tctttccggc ggcgtcatcc agcaagaaac tcgccgttat gatgaagcaa cgaagaaaac 655501 cattcttatg cgtgtcaaag agggatctga cgactaccgt tacttcccag agccagatct 655561 agtcgagctc tacattgatg atgaatggaa ggaacgcgta aaagcaagca ttcctgagct 655621 tccggatgag cgccgcaagc gttatatcga agagcttggc ttgcctgcat atgacgcaat 655681 ggttctgacg ctgacaaaag aaatggctga tttcttcgaa gaaaccgttc aaaaaggcgc 655741 tgaagctaaa caagcgtcta actggctgat gggtgaagtg tcagcttacc taaacgcaga 655801 acaaaaagag cttgccgatg ttgccctgac acctgaaggc cttgccggca tgatcaaatt 655861 gattgaaaaa ggaaccattt cttctaagat cgcgaagaaa gtgtttaaag aattgattga 655921 aaaaggcggc gacgctgaga agattgtgaa agagaaaggc cttgttcaga tttctgacga 655981 aggcgtgctt ctgaagcttg tcactgaggc gcttgacaac aatcctcaat caatcgaaga 656041 ctttaaaaac ggaaaagacc gcgcgatcgg cttcctagtc ggacagatta tgaaagcgtc 656101 caaaggacaa gccaacccgc cgatggtcaa caaaattctg cttgaagaaa ttaaaaaacg 656161 ctaataaaaa agcagccctt agaggctgct ttttttatgg tcaaattgag ataaagacaa 656221 gatgagggcc cgaagccttt caacttcttt gtcgttggtt ccggccaaat tggacagcat 656281 gcctttaata atcggcttgc gcggtttatc ctgagtcaat tcttcctcga taacatcaag 656341 tgacacggtg atatcctcgg gcagcgtgct gttttctttc actttctgaa tgtcctcaag 656401 cagctggtct tttcccgcag gcatcgggtt aaaaatgtct tttgatacaa tcggattgag 656461 tgcagaacgg ctcagcccct gtacaagatc atccagtctc tcaataataa aggctgagat 656521 ttcttctgca tcgatattaa gctcaccgtt aaataccatc acgttcatat aggaatgcac 656581 aatgcctctt gccatgatgg acagatctgc gacataccgc tcgattcctt cgccatagga 656641 taccagcaag gcgttccggt acagcttatc cgtctccatg gttactttgt aaaagtattg 656701 cttgatttct tgattttccg gaatgatatt ttcggtaagc aaaagaacga taaaatcttt 656761 atgatcgcga aaatcctcaa attgagcgcc aatttgcttt tttaacactt ccttaggcgg 656821 ctttccggcg agatcttctt ctatattttt cattttgttc atagacatac cgatataata 656881 ttcacaggca gataacagca gcgcttcttt cgatttgaag tgcaaataaa aagcgccctt 656941 cgaaatgccg cattcactgg cgatttcttg gatcgtcgta gctgcgaatc cttttttcgc 657001 aaataaacga atgctggttt ttatgattct ctcttttttt tcattcatga cgtgcttccc 657061 cttaatcctt gaaaaattta gtaaaatttt ctggtatatg agttgacgtt gttgcgttat 657121 aacgtttagt attatataga atgaccagtc agtcaataaa aaatgtaatg gaggatatga 657181 tgaaccacgt tattaatttc gttctgaaaa acaaattcgc cgtatggctg atgacgatta 657241 ttgtaacggc agccggcttg tatgcgggta tgaatatgaa gcaagagtct attcctgacg 657301 tgaacatgcc ttacttgacg atcagcacga catatccggg tgcaacacca agccaagtgg 657361 ctgatgaagt gaccaaaccg gttgaacaag ccgtacagaa cttggacggt gtcagcgttg 657421 tgacgtcgac gtcctatgaa aacgcatcgt cggtcatgat tgaatatgat tatgagaaag 657481 atatggacaa agcgaaaaca gaagcagctg aagcgttaga aaacgtcaac ctgcctgatg 657541 acgcgaagga tccggagatt tcacgctaca gcttgaactc attcccgatt ctgacgctga 657601 gcgtgtccag tgataaagat aatctgcaag agctgacgaa acaagtggag gacagcctcg 657661 tttctaagct tgaaggcata gaaggcgttg cgtccgtcca agtatcaggc cagcaggtgg 657721 aagaggttga attctctttc aaagaagaca aactgaagga atacggcctt gatgaagata 657781 cagtcaagca agtgattcaa ggttcagatg tgacaactcc gcttggattg tacacattcg 657841 gaaatgaaga aaaatctgtc gtcgtcagcg gcgatattga aacaattaaa gatttgaaga 657901 atatgagaat cccgacggca tctgcttcaa gtgcaggcag cagcgcagca tctcaagcag 657961 gtgcgcagag tgctcaagca gcccaaagcg cgcaagcggc agcacaggtg cagcaaagcg 658021 caagcacagc agtgccgacg gtcaagcttt ctgacattgc tacaattaaa gatgtgaaaa 658081 aagctgaatc cgtttcacgc acaaatggca aagacagcat cggcatcaac atcgtcaaag 658141 caaacgatgc gaatacggta gaggttgccg acgatgtcaa agctgagctg aaaaagttca 658201 aagaagacca taaaggcttc aattacagcg caactctcga catggcggag ccgatcacac 658261 agtcagttga cacgatgtta agcaaagcca tcttcggtgc tatttttgcg attgtgatta 658321 ttctcttatt cttaagagat atcaaatcaa cattaatttc tgttgtttca attccattat 658381 cattgctgat cgcactcctt gtgctgcagc agcttgatat cacattgaat attatgacgc 658441 tcggcgcaat gaccgttgcc atcggacgtg tagtcgatga ctccatcgtt gtgatcgaga 658501 acatttaccg ccgcatgaga ctcaaagatg agccgctccg cggaaaagcc ttggttcgtg 658561 aagcgacgaa ggaaatgttt aaaccgatca tgtcatcaac gattgtgaca atcgcggtat 658621 tcctgccgct cgcacttgta ggcggacaaa tcggtgaatt gtttattcca tttgccttaa 658681 cgattgtttt tgcgcttgcc gcatccctag tgatttcaat cacgcttgtg ccgatgctcg 658741 cacacagcct gttcaaaaaa tcattaaccg gtgcgccgat taaagcgaaa gaacacaaac 658801 ctggcagact tgcaaacatc tataaaaaag tattgaactg ggcgctgagc cacaaatgga 658861 tcacgtctat catcgcggtt ctgatgctcc ttggaagctt gttcctcgta ccgttaatcg 658921 gtgccagcta cctgccgtcc gaggaagaaa aaacgatgca gctcacatac agcccagaac 658981 cgggtgaaac gaaaaaagaa gccgaaaatg aagctgaaaa agcggaaaaa atcctgcttg 659041 accgcaagca tgtcgatacg gttcagtatt cattaggctc tggcagcccg cttgccggag 659101 gagattctaa cggtgcgtta ttctatatca aatatgaaag cgacacacct gactttgata 659161 aagaaaaaga taacgttctg aaggaaatcc aaaagcaatc tgaccgcgga gaatggaagt 659221 cacaggactt cagctcttca ggcaataata acgaattaac atactatgtg tatggcgatt 659281 ctgaaaacga tattaaagac acggtcaaag acattgaaaa aatcatgaaa gatgaaaagg 659341 atctgaaaaa cgtaaattca ggcctttcca gcacatatga tgagtacaca tttgtcgctg 659401 accaagaaaa actaagcaag ctcggtttaa ccgcgtctca aatttctcag gccttaatgt 659461 cacaaacatc gcaagaaccg ctcaccactg tgaaaaaaga cggcaaagag cttgatgtga 659521 acattaagac agaaaaagac gagtataaga gtgtgaaaga tttagagaat aaaaagatca 659581 cttccgcgac tggccaggaa gtcaaaatcg gcgatgtggc aaaagtgaaa gaaggatcaa 659641 catcagatac cgtgtcaaaa cgtgacggaa aagtctatgc agatgtcaca ggtgaggtta 659701 cctctgacaa cgtcacagcc gtatcagctg ctatccagaa gaaaatcgat aagcttgacc 659761 accctgataa cgtatcgatt gacacaggcg gcgtatcagc ggatatcgct gattccttca 659821 cgaagctcgg tttagcgatg ctggcagcaa tagcgatcgt ttaccttgtg ctcgtgatta 659881 ccttcggcgg agcactagcg ccatttgcga ttctgttctc attgccgttc acagtcatcg 659941 gtgccctggt cggactttac gtatcaggtg aaacgatcag tctgaacgcc atgatcggta 660001 tgctcatgct gatcggtatc gttgtcacga atgccattgt cttaattgac cgcgtgattc 660061 ataaggaagc ggaaggcctg tctacgagag aagcgctcct ggaagccggc tctacacgac 660121 tccgtccgat cctgatgaca gccattgcga caatcggcgc cttgattcca ttagccctcg 660181 gcttcgaagg cggaagccag gtcatttcaa aaggactcgg cgtaacggtt atcggcggtt 660241 taatcagttc aacgcttctg acgctcctga tcgtgccaat cgtatatgaa gtattggcga 660301 agttccgcaa gaaaaaaccg ggaacggaag aagagtaaaa aacaaaaagc ctcagctctg 660361 ctgaggcttt cagcttgttg aaaaaccctc gcattcgttg tcaggtctgc gcgtcggtgc 660421 tcacgaattc tacattcgct ccgctccaat gctccccctt cctagactac aagggttttc 660481 aatcaagctg aaagaatgtt aaggatgaca aaagctcaaa acaagaatca gttttgagct 660541 tttgtgcgtt ttcacctgta agattatgta cattttgttg cgattttttt aactcatagt 660601 ataattaaag gttgttagtg taaaaatgga tcggatactc ttaagtagga tgatgagata 660661 atgaaacgtg cacgcataat atacaatccg acttcaggac gggagatctt taaaaagcat 660721 cttgcccagg tcctgcaaaa atttgaacaa gccggctatg aaacctccac ccatgcgacg 660781 acatgcgcag gagacgctac acacgctgcc aaggaagcgg cattgcgtga gtttgacctg 660841 atcattgcgg caggcggaga cggaacgatc aacgaggtcg tcaacgggct tgcgccttta 660901 gacaatcgtc cgacactcgg tgtgattcct gtcggcacaa cgaacgactt cgccagagcg 660961 ctcggaatcc cacgcgagga tattttaaaa gcggcagata cggtcattaa cggcgttgcc 661021 cgcccgattg atatcggaca ggtcaacggc cagtatttta tcaatatcgc cggcggaggc 661081 cgtctgacgg agctgacgta cgacgtgcca agcaaactga aaacaatgct cggccagctt 661141 gcttattatt taaaaggaat ggaaatgctg ccttcacttc gtccgacaga agtcgagatt 661201 gaatatgacg gcaagctgtt tcaaggtgaa atcatgctgt ttttggtcac gctgacaaac 661261 tccgtcggcg ggttcgaaaa gctcgcgccg gattccagcc tgaatgacgg catgtttgat 661321 ttgatgatac taaagaaagc aaaccttgct gaatttatca gggtcgccac gatggcgctt 661381 cgcggagaac acatcaacga ccagcacatt atttatacaa aagcgaaccg cgtgaaagtc 661441 aatgtatcag aaaagatgca gctgaacctg gacggcgagt acggcggcat gctgccgggc 661501 gaattcgtga atctgtaccg gcacattcac gtcgtcatgc cgaaggagaa agcggaacag 661561 ttggatgact aaaacttggc ttggtaagcc aagctcagaa tgttgacaaa atcctaaaac 661621 agttttcgtt ttaggatttt gtcatctttt cagcgtgatt gaaaaccttt gaagtctagg 661681 aagggcgagc atcggagcac agcgaatgtt gaattcgtga gcaccgaagc acaggcctga 661741 caacgaatgc gaaggtttgc ctacacgctg aaacttggct tgaataggcc aagtttttct 661801 ttcgcttaaa actagaggtg attatagatg aaaatgaaac ccccagtaga aaaaaatgaa 661861 tactacgatg tgacatttga ggatttgaca catgaaggag cgggcgtcgc aaaggtccaa 661921 ggcttcccga tctttgtgcc gaatgcccta cccgaggaaa aagcccaaat caaagtgaca 661981 cgcgtcaaaa aagggttcgc cttcggccgc ctgattgagc tgaaggaaga aagcccgcat 662041 agaacggacg ccccatgccc gatttacaaa caatgcggag gctgccagct tcagcacatg 662101 acctacgaag gccagctcct gtttaaacag aaacaagtca aagacgtctt agaacgcatc 662161 ggcaagctgg acctttcaaa agtcaccgtg cacccgacac tcggcatgga agacccgtgg 662221 aactacagaa acaaagcaca ggtgccggta ggagaacggg aaggcggact cgtcgcggga 662281 ttctatcagc aaagaagcca tgacatcatc gacatgagcg cctgcctgat ccagcaatcc 662341 aaaaacgacg aagccgttca agctgtcaaa gacatttgcg caaactacgg tgtcaaagcc 662401 tacaacgaag aacgccacaa aggctggctc cgccacatca tggtcagata cggcgttgtt 662461 acgggcgaaa tgatgatcgt cttcatcaca agaacaagcg acttcccgca caaagcgaag 662521 atcatcgaag acatcacagc gcaattcccg cacgtcaaat ccatcgtgca aaacatcaac 662581 ccaaacaaaa caaacgtcat ttttggcaac gaaacaaacg tcatctgggg cgaagaatac 662641 atctacgacc tcatcggaga cgtcaaattc gccatctccg ccagatcgtt ttatcaggtc 662701 aacccagagc aaacaaaagt gctctacgac aaagcgcttg agtacgctga gcttcaaggg 662761 gaagaaaccg tcatcgacgc ttactgcggc atcggaacga tttctctctt cctggcaaag 662821 caggcgaaaa aagtgtacgg tgtagagatt gtgccggaag caattgagga cgcgaagcga 662881 aacgccgaat taaacggcaa cacaaacgca gagtttgctg ttggagaagc ggaaaccgtg 662941 attccaaagt ggtacgaaga aggcattaca gctgatacgc tggtcgtcga cccgccaaga 663001 aaaggctgcg acgaagccct cctgcggaca attgtggaga tgaagccgaa gcgggtagtg 663061 tatgtgtcct gtaatcctgg cacgcttgcg agagatttgc gggtgcttga ggatggcggg 663121 tacgtgacgc gcgaagtgca gcctgtggat atgtttccgc atacgaatca tgtggagtgc 663181 tgtgtgttga taaaattaaa agaataaata gtcaaaaatc tatgctgatg gaactgttgg 663241 ttctctaaaa cgataattga tttcaatggt tccatttgca tgtacttcta tttcatctac 663301 taacaaatga agcatttcgg gggtaagtgt accttccttc atgaatttat ctaagctctt 663361 tttaaaatca attatttctt tttcaatctt ttgaaattct aggtccttag atagttggtg 663421 aagggtagtt tcaaaatttg aaatatcttc attggtgata tttatggcta attggtaatc 663481 ttctttagat ataacaccat tagcaagaga gataactaaa ttggatttat ctctcttttt 663541 atcgtttaat ttttcattaa tttcgattat cttagattcg attttttctt tgtactttaa 663601 cgctttttca cttaattctt taaaataatt ttccttactg aatttcaaat atatcttatt 663661 taggttggtt attactttat cagttaaatc tatttcactt acgtaatgat cactacatgc 663721 ttttaaacca tgtttattat aacttccaca aacataacct tttcgattct ttttaaaatg 663781 cattgacctc ctgcaatctt tgcaaaccgc agtatttgta aagagatgta cttcagcttg 663841 aggtctcctt ctttttctag ttattaaaat ctcttgtaca ataagaaagt cttctaaagg 663901 tatgattggt tcgtggcttt tttcaataat tatttggttt tctaggttaa ctgaccttct 663961 tcttttactg gtaacactcg gtctatattc tctacattgt tgtagtgtcc cagtatagtg 664021 aggattttcg agaatttttc ttattgaaga tccgtgccat ttgtcagtag cgttcttttt 664081 gcgggcaagc tgcgagggac tagtgacccc ttcgttatac aatccccttg ctattgcatc 664141 aaagcctttt ccagcaatat attctgaaaa gattctaata tttactattt tctctgcgtt 664201 tgctgaattt gagagagata tgattgtaga acgaactcaa gaaggtaaaa tgttggccaa 664261 gcagaatccg gatttccgag aaggaagacc caaaaagttc acaaagcagc aaatcaatca 664321 tgcattaaca ttactagaaa atcattcgta taaacaagtt gaagatatga ctgggatatc 664381 agtttctaca cttgtaagag ctaaaaagaa gaaagctgct gaagctataa atggataaat 664441 attgtgaatt aattattcaa tatcttgaga aatttttata aaagtaatca aaagtttaat 664501 gggggaaacg aaatggcgct cattgattta gaagataaaa ttgctgaaat agtgaatcga 664561 gaagatcatt cagatttctt gtatgaatta ctcggtgtat atgatgttcc acgagctaca 664621 attacgcgct tgaaaaaagg aaatcaaaac cttacaaaac gggttggtga agtacactta 664681 aagaataagg tgtggtttaa ggaggctaag aaaggaaagc tctttgacgc ccttattgat 664741 atagaacaac aagttgaata tctttcagct aagccacgat atttattagt tactgactat 664801 gatggagtat tagcgaaaga tacaaaaaca ttagaggctc ttgatgttaa atttgaagaa 664861 cttcctcagt atttcgattt cttccttgct tggaaaggta ttgagaaagt agagtttgaa 664921 aaggaaaacc ccgctgatat taaagcagcc gaacgttttg cacggatata tgatgtactt 664981 cgtaaagaaa acaatattat tgagactaat agagggttag atttatttct tattcgttta 665041 ctgttttgtt ttttcgcaga agatactgac atcttcaaac gaaatagttt tacgaattta 665101 attaagactt tgactgaaga agatggttca aatctaaata aattatttgc tgatttattt 665161 atcgtgttag ataaaaatga acgagacgat gttccatctt atttaaaaga gtttccgtat 665221 gtaaatggcc agttgtttac tgaaccacat acagagttgg aattttctgc caaatccaga 665281 aagttaatta ttgagtgcgg tgaattatta aactgggcta aaatcaatcc tgatatcttt 665341 ggttcaatga ttcaagctgt tgcttctgaa gaaagccgta gttatttagg tatgcactac 665401 acaagtgtcc ccaatataat gaaggttatt aaaccgcttt tcctagataa acttaatcag 665461 tcttttttag atgcatacga tgattataca aaacttgaaa atcttctaac acgaatcggc 665521 aaaattaaat tctttgatcc tgcatgtggt tcagggaact ttttgattat tacctacaaa 665581 gaattacggc gtatggaaat caatattata aaacgacttc aagaactctt gggagagtat 665641 ctttatgtac cttcagtaac tttatctcaa ttttacggaa tagagattga agattttgca 665701 catgacgttg caaaattatc actttggatt gctgaacatc aaatgaatga agaattaaaa 665761 aatgaagttc ataatgcagt acgcccaacg ttaccacttc atacagcagg ggatattcgt 665821 tgtgcaaatg ctattagggt tgagtggact gaggtttgtc ccgcacaagg atctgaagaa 665881 gtatatgttt ttggtaatcc accgtatctt ggttcaaaaa aacaaaacaa agaacataaa 665941 tctgatatgt tatcaatttt tggaaaagtc aagaatggta aaatgcttga ttatatttct 666001 gcttggtttt actttggtgc taaatacgct tcaactacaa atgcaaaagt tgcctttgta 666061 tcaacaaatt cagttactca aggggaacag gtttctatct tatggaatga gttattcaag 666121 tttggaattc aaatcaattt tgcctataaa tcttttaaat gggcgaataa tgctaaaaat 666181 aatgctgcgg taattgttgt gattgtaggt tttggcccgt tagataccaa agtaaacaag 666241 tatttatttg ttgatgaaac gaaaaagcta gtttctaaca ttagtcccta tttaactgat 666301 ggtgaaaata ttcttgtttc ttctaggacg aagccaattt cagacttacc caaactgcat 666361 tttgggaaca tgcctaatga tggcggagga ttactcttta ccattacgga atatacagac 666421 gcaatcaata agtatcctga attagttccc tattttaaaa agtttatagg ttcagtagag 666481 tttattaatg gtggtttacg gtattgttta tggcttaatg aagcaaaata tgaaaaaata 666541 aagtctaatc ctctaataca agaaagaatc tcaatttcaa aaaatcacag ggaaaaatca 666601 acagataaag gaacgaataa acttgcatta actccgtgga agtttagaga tactcatgaa 666661 acaactaatt attccattgt tgttccatct gtgtcttctg aaaatagatt ttatattcca 666721 atgggattag caggtgcaga tacaattttg tcaaatctaa tttatgtaat ttacgatgca 666781 gaaatttacc ttctaggcat tttgatgtca cggatgcata tgacttgggt aaaagctgta 666841 gccggaagat taaaaactga ctataggtac tctgcaggtt tatgttataa cactttccct 666901 attcctgaat tatcaacaag aaggaagaat gaaattgaag aagcaattct tgaaattctt 666961 gatcttcgtg aagagcaggg tggtacatta gcagagcttt ataacccttc aacaatgcca 667021 attgaattaa aagtagcaca tgaaaagttg gatggaattg tagaaagagc gtatcgtcaa 667081 aaacaatttg aatctgatga agaacgctta gaagtattgc ttaaattgta tcaagaaatg 667141 acagaacggt aggtgtaagg tgtatggaaa atataattga aattaattat aaccaaactg 667201 gtaaaagtaa gaaaacaaat gaatacggta tgcgtgaaat gcaggcaaga gcttttgaaa 667261 aacgtaactc acaatatctc ttagttaaag caccgccagc ttctgggaaa tctagagctt 667321 taatgtttat cggtttggat aagctcataa atcaaggttt gaggaaagtg attgttgctg 667381 tacctgaacg ctctataggt tcttcattta aaaatacgga tttaaaaagt tatggtttct 667441 ttgaaaattg gaaagttgat cctagaaata atttaactgt tggcggagat aactctaagg 667501 ttaaatcttt tgttcgtttt atggaatcgg acgatcaggt gttaatatgt acgcactcta 667561 ctttgcgatt tgcgtttgaa aaaattgatg ataaagcatt tgataattgt ttacttgcaa 667621 tagatgaatt tcaccatgta tcggcagatg tcaattctcg attaggtgaa ttgttaagaa 667681 gtattattca taattcatca gcacatattg tagcgatgac tgggtcgtat ttccgtggag 667741 attctgtacc aattttatta ccagaagatg aggaattatt tgacaaggta acttattcct 667801 attatgaaca acttgatgga tatgaatatc taaagggatt tggtatagga tatcacttct 667861 atcaaggcca gtacacatca gctattaatg aagtattgga tacaaataag aaaacaatcg 667921 ttcatattcc aaatgtaaac tcaggggaat cgacaaagga taagtacgat gaagttggta 667981 agatacttga tatgattggt gaagttgaat atcaagatga tgatactgga attatttatg 668041 ttaagcgaca ttctgacggt aaaacattga aaattgcaga tttagtagat gaccaagttg 668101 gaagagaaaa tgtcgttgcg tatttgcgta atattgaagc cctagacgat ttagatataa 668161 ttattgctct tggtatggcg aaagagggct ttgactggcc gttttgtgaa catactttga 668221 cagttggtta tcgtggctca cttacagaaa tagtacaaat aattgggcgc tgtacacgtg 668281 atagttacaa taaaacctat gctcaattta ccaacctaat cgcaatgcct gatgcaaagg 668341 atgaagtagt gacttataca gtgaatacaa tgcttaaagc tatttctgcc tcacttttga 668401 tggagcaggt ccttacacct gactttaaat ttaaacgtag aagaaatgaa agtgaaaaat 668461 cttctactac aggagaatta ttcgttaagg gattgaaaga accatcaaca gaaaatgtca 668521 aaaagattat tgaaaatgat attaatgatt taaaagcaaa aatcatgcaa gattcacaag 668581 tccaaaaaac atttagtgga gaagtagatc ccaaagtatt gaacaaagtg ttgattccga 668641 aagttattca aaaagtatat ccaaatttat cagatgagga aattgaggaa gttagacagc 668701 acgttgttct agatacagtt atgaaaggtg ctaagtctga agttgtagga agtaaagaat 668761 ttataagaat ggcagataag tttataaaca ttgaggattt agatatcaat ctgattgatt 668821 ccatcaatcc gttccaaaaa gcatttgagg ttctatcgaa agaattgaac tcaccagtgc 668881 taaaactgat tcaggaaact attgatgcaa aacgtattaa ttttgatgaa gatgaactag 668941 tattcatatg gccaaaggtt taggaatttt atcgttcaac tggtagaaga cctgattcaa 669001 aatctgaaga cccacttgaa aggcgtatgg gtgaagctgt attatacatg caagagctta 669061 ggaggaaacg tgaaaatggc aagtaataga taccattcta ttaatgaaat catggaaagt 669121 cagctgtttt accaaatcac aacaccacct aagaaaacac aaaaagccca gtatgatcct 669181 gaagttgaaa agtttttgga gattattgaa ttcgtcaaag aaaatgggcg agaaccccaa 669241 aaagtcccta ctgatttaac tgaaagaagt ttagcaagtc gattaattgg gattcggaaa 669301 gatcctgatc gtatggaata tttgaaagag tatgatgaaa ttggattact tgaagtaaga 669361 tcgaaggaac taacaattcc taaaatttct tcaattgatg atattctaaa aagtggctta 669421 tctgcattat taggtgataa tttaaataat gatataacta ggtcaatttt tgatacaagt 669481 tcacttcaaa aggttacgac aatgcctgaa tacgttgcaa agcgtaaaaa aataaaagat 669541 tttggaaagt ttgaagagct attcaagaag tgccacaagg aaattacaga gggtaaacga 669601 aaaattttaa ctttcaaaaa tgaacaagac atacagtcaa atagttttta tatattaaaa 669661 ggagttcttc tttatgttga agatgtggga gaacgtaaaa aagcaaaggg aaaaaccaat 669721 gctagacttc gatgtatatt tgaaaatgga acggaatcag atatgttact acgttcctta 669781 tcagcggagt tatataaaca tggtagacgt gtgaccgaca atgaagatac attgttggat 669841 aatgttagag aagatgatgt ttcgactggc tttatttacg tactaaaatc tttgagtaca 669901 gatccgcaaa ttagttccat taagaattta tataagatcg gttttacaac tggttcagta 669961 gaaaatagaa tcaggaatgc agaaaatcaa tcaacttatc tttatgctcc agtagaaatt 670021 gtaaccacat atcaagtgtt caatatgaat gctagcaaat ttgagacggc aatccatcat 670081 gcgctagcaa ataataattt ggatgtttct attttggggg caaatggaaa gatgttagtt 670141 cctaaagagt ggttcgttgt cacacttgaa gatttacaag ctgtaataga tgagattgtg 670201 atgatggttc atctttatga ctaaattagt atattaggat tttagtatta ataataattt 670261 tatagtagac tatgaaaaaa tttgatgcca taacaataac ttgttccgct ttggagtttg 670321 tcacaattgt agaattatgt gttgcgagta ttaataggaa ggggttgagc gaccgcaaaa 670381 aaaattttcg gtgctgtccg caaaagggag tttgggtgtt ttgcgttata tttggttgtg 670441 tgaaggttag cggaaactca attcgtgaag ttaggattgc ggttattacg actgagtagt 670501 ttcgtcatac tcttttagca gtttttctgt cttatgcatt tctttgagca tcggattcat 670561 gtagtcgtta gctgattcta gatatgctct cgtcagagtg tctagtttat ttctaacttt 670621 agagaggtct tcttcgaatt ttccatccga tgattgaagg ataaattctt ttgcctcttc 670681 atatcttttt aatatgtttt tcaccattgg agttggattc ttttgattta ttgtttttat 670741 tacagtgatt gttaaattta tttgttttat taattctttt cttactgtca aggtgatgct 670801 ccttttaaat ctctattcta tttgagagtt gctatatctg tttaatggtt tgatagacta 670861 ctcatcttta taatttagag caatttttac aacttgttcc gctgtgtaat cttcattgct 670921 ccagaaaatt aaatcacttg gtgccggata aggaacattt ttctctaata aatcgagata 670981 ttcactgact ttctcatcat ctaatgttgg gttcattaat tcctttacaa gaaagatcaa 671041 ctcttctttt gtcagtttat ccattgtttg ccctccaata gattgtatct ccattgattt 671101 tacaaatgac tttatttctt ctgataatgt tataggttgt ttgcataatg atagataatt 671161 gtcttgagaa aagttagtct cattatagag tttattaatt gtatttataa caatatattc 671221 atatggaaaa cctctaaaat atctttattt tagattggtt tataaaaaat agctcagcag 671281 agtagggctg agccattttt taattataga ccgaggtaac taattacaaa ttctttatca 671341 tcctcatctt caggcaaaat accaaggttt ttatattccc atattgcgat tctttcatat 671401 ccatctaatt ctgaggctaa aatatcatca taattataat ctaattggaa ttctccgcta 671461 cgatccaatg ttagtgtaag gttagtccaa acatcatcgt tattatttct gtgttcagtt 671521 cttaattctt caaaaagttc tcttagttct cttaacaacg tcttgaaaat atccttgctt 671581 acgttgtaat ggctaggtat atcttgtgaa taaataattt gattattttc tggtgttctg 671641 aaatgaaaaa gaaccattgt ggaatcatct aatacttctg cataaagata tatctttgtc 671701 cattcaccag gtatgatgtc attgagtttt tctccaataa gttgatacaa atcttgcatc 671761 ttcctagttt ccattcttct aacccccagg ctgattttta atagagacgc ttatttcttt 671821 tctgctccca attttgtagg ttacatcgaa atatgatggt ctaagtgaat ccccagaata 671881 gactggttct atttgaactg ctactttttt aggtggtttt ttgcttaggg cttttgccca 671941 ctcctgctcc atctcatacc atttcccacc gctcctatta atctgagaat tcatcggcac 672001 gatattgtca aactggcctg agcctttgaa ttgggtggcg attaaatggc cgccgtcatc 672061 gtcaggcttt cggtcctggg gctttccagc attcgtttgt gcatattggt ttcgtttcgc 672121 ttctcccagc tgcaagtctg ctttgacact tgtaattcta ccatagttgt cagtcgtgta 672181 cgtgtagcct tcttttgttt tgtagatgat attaggcttc agcactttct ttctgctcca 672241 tcttgcgaaa tgctcgccgt atttgacggt taccggcggt acatgtggcg ctggagttcg 672301 tcttccgctt gatgacgttc cgtatggttt cggcaggatg accttggcga atttttgcag 672361 tccttcttta agcgtgaccc cgttgactgc gttgtaagga acgcctgccg gcactaaatc 672421 atgacgggga tgatacggga gaatatccgc aagtgtgaga tctccgattt gatttaactt 672481 ggttttgacg tgtttttttg atacttcaat gcctgtgttt actttttgtt tgatgtgatc 672541 aacggtttgt tttgagactg ttatggcttt ttgggctgtt gctgatttgc ttgctgctgt 672601 tttgactttg gtcgtcactt tggcggctgt gccagttttt gagacggctc ctacgccttt 672661 tgtgccgaca attgatgtga caacagtgcc aaccgcatat gacacccatc ttgctcttga 672721 gtaggtgtca ccattcacca tgtctttttg atacgattct tcgattgccg ctgaaatggc 672781 ttcatacgtt ttgatcgggt gagccatcgc tccggtaatc gcttcaacgg ttcctcccgg 672841 atctgtgacc atatcccaca ggcctacgac cgcgtctttc ccggaatcat aaaggccgac 672901 ggcaacccct ttgaagcctg cttcaagctc acgcgtgttt tcaatttggg tgaagtatct 672961 ctgttgttca gctgtcagat tttcatagcc gatcgttttt gccatttcgt agaattcatc 673021 ggcatctgca taatcgtagt ttttcagtct ttctttcagt ttctcaatct cgcgttcctt 673081 cgcttcctct ttcttaatct tcaagtaagc ctcagtccgc ttttcaatgt cgcctttttt 673141 cttatgtatg tcactctcac ggtacgcctt ggcgttgtag tggatgggtg tggcgttttt 673201 gcctttaccc gttgcttctt ggagcttttg gaagtcggat ttgatgaatt gttcgtttgg 673261 ttcagacagg gcgtattctg ttttcaggtc ttcgtccaag gcgtccaatt tttccagtgt 673321 ttttttgcgt ttgtcgttgg catcggccag ctcgtctttg aaggtttctg ttgaaaacag 673381 gtcgagcggg aggatgtcgt cgatatcgtt taggatgtct ttcatcgctt ttttctgttc 673441 ggacatgatg gatttagatt ttttattggc atttgccagt tcgtgctcca ggaaggattc 673501 ttcgatgtat gcgtctgaga ggcctttgtc ttcggcggct ccggcgatgc tgttgaaaaa 673561 tgcgattttc atgtcgatgt agtcgatcca ctggtcggcg acgccgacgt ggtcgtgata 673621 gaatgccttg atgttgctgg cgccttttcc tgagaattca ctgtcactga gatcagcgac 673681 tccttttaac gcttttctca agttgaccat ttgcgttctt agttctttgt actcttttgc 673741 acggtctgtc gcttccgaaa gcagtgtttt cgcttcaaat actttcatga ccatttccct 673801 tcttttgttc gctcaatatc aaaattttac cacgggtcgg gataaggtgg gggtgagaac 673861 gtgttttggt ggaaaaatga gtcatttggc atgtgtcttt attcgtggag ggattggagg 673921 aaacatggtc gaaatgatat tgattgctac acattttttg gaagtttgta ttctatattg 673981 ttttttaagg agcatgttga tgacgaaaaa acggattaca tttggtttat tagttttaat 674041 ggtatgtgtc atcctgtttg ttctgtatgt tcagttacgc aataaagata gtattcctgt 674101 ccaatcttcc gccattcacc ccgaagaaga ccgcatcttt tttatttact ccaatccttt 674161 cataaaagaa agcgtgctgc tttcaacctc tacaggcgaa cggtttaaca ggcgtacgtt 674221 taaggtggcg gatgtgcctt atattcaaac gaaatcttat gcatcaacag accttgtatt 674281 attggcggaa cacgagcctt tttactacac gctggagaag gatgtgatca aagagcatcc 674341 gctgtcagat ccatttgcgt tttggtatga ggggaaggat gtcactattg aggcctataa 674401 tgttgatacg acgggaaatg agatccacat aaacgacaga aaaacgaaaa aggaatatac 674461 ccttaccttg cctccgcttg tcacaatggg ggccagtgat gagaacttta tttatatcat 674521 tcaaagcatg tctatttacg tgattgacag aaaaacagag gaaatgattg agaccctgag 674581 cttagcctca tacgctgatc aattcgcaga ctcggaggaa tttatcgtcg cgagctcgga 674641 tcataaattg actgtgattg aaaaagggac atggaagacg acatatattg cgtatcctga 674701 agatcttgaa tatgcagata ctgtgtacta tgacaaagaa agcggcagtt tttacgtggc 674761 gtacgaggac aaagagggtg gagcgaactt gctggaatat ggggaggatt tttctattca 674821 cacatacagc ttgaaattcc cttatatgga ggcgaagttt aaggggaatc tattgtatat 674881 agttgcccag gaagagcata aaaagggcat cggcggatac gtgggtgtgt ttgatatcca 674941 ttctaaggag atgctttatc agtttgattt gcctgaggaa caggtgaagg ttcaggattt 675001 tgttgtggtt gacaataagt gaatactata tgaaatagaa tgacaaagac ccttgcataa 675061 agggttcttt tttatgaaaa aaacaaattg acaggatgaa aaaacaattt cttccttcta 675121 tattgttttc aaaatttggg attgatagaa tatgacatat ctcatagaga aggagggaag 675181 ccgttgagtc aagccatacc gtcttcgcgt gttggtgtta agattaatga atggtataaa 675241 atgattcgcc agttcagtgt tccggatgct gagattctga aagcggaggt tgagcaggac 675301 attcagcaga tggaagaaga tcaggattta ctgatctatt attctctgat gtgttttcgg 675361 caccagctga tgcttgatta tttggagccg ggaaaaacat acgggaatcg ccctacagtg 675421 acagagcttc ttgaaacgat cgagacccct cagaaaaaac tcacaggtct tttgaaatac 675481 tactctttgt ttttccgcgg catgtatgaa tttgaccaaa aagaatatgt ggaagcgatc 675541 ggatattatc gcgaggcgga gaaagaactg ccgtttgtgt cagatgatat tgagaaagcg 675601 gaattccatt ttaaagtggc agaagcgtat tatcacatga agcaaaccca tgtgtcgatg 675661 tatcatattc ttcaagcctt ggacatttat caaaaccatc ctctatacag cattagaacg 675721 atacaaagct tgtttgtgat cgccggcaac tatgatgatt tcaaacatta tgataaagcg 675781 ctcccgcatt tagaggcggc gctggaattg gcaatggaca ttcaaaatga caggtttatc 675841 gccatttctc tattgaacat tgcaaacagc tatgacagat caggagacga tcagatggct 675901 gtagaacatt tccaaaaagc ggcgaaagta agcagagaga aagtgcctga tctgcttccg 675961 aaagtcttgt ttggattaag ctggacatta tgtaaagcgg gccaaacaca gaaggcgttt 676021 cagttcatag aggaaggatt agaccatatc acagcacgtt ctcacaaatt ttataaagaa 676081 ttgtttctgt tcttgcaggc cgtgtacaag gagactgttg atgaacgaaa aattcatgat 676141 cttttaagct atttcgaaaa aaagaacctg cacgcttaca ttgaagcatg tgcccggagt 676201 gctgccgctg tttttgaaag cagctgtcac tttgaacaag cagctgcgtt ttatcggaaa 676261 gtgctgaaag cccaagaaga tattctaaaa ggagagtgtt tatatgccta ttaagaaaaa 676321 agtgatgatg tgtctggctg ttactctagt tttcggaagc atgtcgtttc caaccctgac 676381 aaactccggt ggatttaagg aatcgacaga tcgaaatacg acgtatatcg atcattcccc 676441 ttacaaactt agtgatcaga agaaagccct tagctagggc tttttcttgc tttacggaag 676501 acgttccatt ttccacatcg cggcattcct tctatttcta acgcaagaca ctcgaaacaa 676561 ccaaaccatt tgaggtataa tggataaagt gaataacagt atttagattg atatatatga 676621 aagagagtgg aacatcatgg gccgtaagtg gaacaatatt aaagagaaga aggcgtctaa 676681 ggacgcaaat acgagtcgga tttatgcgaa gtttggccgt gagatttatg tggcggcgaa 676741 acagggcgag cctgatccgg aatccaacca ggcgctgaag gttgtgcttg aacgtgcgaa 676801 gacttacagc gtgccgaaaa acatcattga acgtgcgatc gagaaggcga agggcggagc 676861 ggaagagaat tacgatgagc ttcgttatga gggcttcggg ccgaacggat caatgattat 676921 cgttgatgcg ctgacgaata atgtaaaccg tacggcgccg gaagtgcgtg cggcgttcgg 676981 gaaaaacggc ggaaacatgg gtgtgagcgg atctgttgct tacatgtttg acgcgacggc 677041 tgtaatcggt gtggaaggca aaacggctga cgaagcgctt gaaatcctga tggaagcgga 677101 tgttgatgta cgtgacattt tagaagagga tgacagcgcg atcgtgtatg ccgagcctga 677161 tcaattccat gcggtgcaag aggcgtttaa aaacgcgggt gtcgaggaat ttacagtagc 677221 ggagctgaca atgcttgcgc aaagtgaagt aacgcttccg gatgatgcaa aggaacagtt 677281 tgaaaaattg attgatgcat tagaagattt ggaagatgtt cagcaggtat atcataacgt 677341 tgatttaggt gagtaaggag tgagcaggct gttatggcct gctttttttg tcccggaaat 677401 tgttttagct gtatgtaggc ggccgcctat acgatctata agatattctc atactctgga 677461 ctgtaaccta tgtgaaggag agagtaaata tgactgatac aagacatatg tatggcggac 677521 ctggttttgg tcattatcag ggctttggta ttggccaccc gggctatggc atgcaaagca 677581 caggctatcc gggctatggc atgtatggag gccacccggg ctatggcatg caaggctacc 677641 cagatcacgg catacatgga ggagtcggcg gctatccggg atatggtggg tacggcggtt 677701 acccaagcgg cggctatgga ggctctccgg gaactggaag ctatccgagc atgcaccatg 677761 aaaatgatgg ccatcaccac tattatcacc atcatcatga tggaaaagat aatcttcatc 677821 accatcatca ccatgttgga aaggataatc atcaccacca tcatgatggt cattatggcc 677881 accatcatca ccatatgggc cactggggaa aagacggtta taaataaaga agatgatgat 677941 aaaaagagga cactcttgca gatcaagagt gtttttttag cttttttctt gactgttcag 678001 tctggaaaat ggtaacattt gtttcaggag gtgatcattt tttggggagg aataaagaat 678061 ttgatacggc gcttgttctt cacagggcga tagaggtttt tggagagtat ggctacgaag 678121 gaacgtctct tcaggatctg ctctctcatt taggcattgc gcgccaaagt ttgtatgata 678181 cgtatggaac gaagcgtgat ttgtttttgt ccgctgtgaa atcgtatctt gaagggaaaa 678241 acgctgccgt tatggaaagg cttgaagcgc caggatctgt aaaggaagcc attcgtgata 678301 tttttcagga gggtgtcaat gccctgaggg atccggaacg ggcgaaggcg tgctacatta 678361 ttaacagcgc gattgaacag atcccgcatg accctgagct tgcccggtat tttgaaagac 678421 aatccaagca gcttgaggac gctttttatc acgggctttt aagagcgaag gatcaaggag 678481 aattgaatgg cgaagatact gatatatctg cgcttgctcg gtacctgaat cagagcaggc 678541 tgtcactgac atttattgca aaagtgacgg cagatatgga tcggcttcag gaccatgttg 678601 acgtgagttt atcagtgctt gattaacatg tggtaaagga ttctttgccc atgtatgtac 678661 tttttggact gaatagtcta gaaataaaaa tgaggtgatg atgaatgttg atgaatgagt 678721 ttgaaaaagc atgtgaaaca ttgagaaagt ttatggctta tatgcttgag aaggacatga 678781 agagctggac ggagctttgg gatgagaatg ctgtatttga gtttccttat gcgccggagg 678841 gatcaccaaa aagaatagaa ggaaaagcgg ccatttacga ttatattaaa gattatccta 678901 agcagattca tctttcttca tttaccgctc cgacagtgta ccgttcagca gactcgaata 678961 cggtgattgc ggagtttcaa tgtgacggcc atgtgattga gactggactg ccttatcgcc 679021 aaagctatat cagtgtcatc gaaacgagag acggccgcat tgtgcgttat agggattatt 679081 ggaatccgct tgttgtaaaa gaggcctttg gaggatcatt tttgcaaaca gaggagagtg 679141 ggaaatgatg aaacagaatc cgattttaat cacgggcggg accggcacag tcggcagccg 679201 aatcgccagc cgtttaataa agctgggata cagagtgcgt attgcaagcc ggaaaaaggg 679261 cgcgcttgct gatgctgagt atgtgtattt taattggaag tacgcctcca gttttacgcc 679321 tgctctggaa caggtaaaac agatctatct tgttgctccg gtcggtgtat ttgatccggc 679381 tccctatgtg cttccctttt taaaggaagc aaagcgtctc ggcgcaaagc gggtagtgat 679441 gcaaagtgcg tctgttgtct ccgagaacgg tcccgtgttt ggcgcgcttc accaggcagt 679501 gcgcgagttt ccagaatgga cggtgctgcg gccctcatac tttatgcaaa atttcatcaa 679561 tgtccagcac cgcatgtcta ttcaaacgga ggggcgcatc acaacggctt cgggtgaagg 679621 aaaacttggg tttattgacg ctgatgacat cgcagaaaca gccgtcaggg ctttgattga 679681 tgatgttcct catcaaacac atcatattct gacaggtccc gaggcgctga gctatgccga 679741 agcggcggag atcattggag ctgcggcggg acgccgggtg gagcatgtca gcatttctcg 679801 ttccgagctg cagcataaaa tggaggcagg aggtttgccc gcggattatg cccattttat 679861 ggcgaagctt gatgaggcaa ttagccatgg tgcggaacat cgggtaacgg atacagtgaa 679921 gcgtgtgacg ggaaaagaac ctcgttcgct gtcagagttt gcggctgctc atgctgcata 679981 ttggacctca ttttggactg aatagtctag aaagaccttc ggcgcttccg aaggtcttct 680041 tattgaaaaa gctaagtcgt gttttagtca taatcatgcc tcctgcctca tacctattaa 680101 ggtcattgtt tttgagaaag gaggagccgg aatgaaggat atgcagccgt ttacgcctgt 680161 caaatcatat acgccctttc acagccgttt tgatccctgt ccgcccatag ggaagaaata 680221 ttacagaacg ccccctaacc tttatatgac ctttcagcct gagcacatgg agcagttttc 680281 gccgatggag gctttgagga aaggcaccct ttggaaggat ctctatgatt tttatgaaaa 680341 cccttatcga gggggagacg cacatggcaa aaaaggttga cgccgaatat tatcgtcagc 680401 tagagcaaat acaggctgct gattttgtgc ttgttgagct gagtctttat ttaaatacac 680461 atcctcatga tgaagatgcg ttgaagcaat tcaatcaata ttccggctat tcaaggcact 680521 taaaaagaca gttcgaatcc tcttacggac cgcttctgca gttcggcaac agccccgcgg 680581 gcaaggattg ggattgggga aaagggccat ggccgtggca agtataagga ggaatgcctg 680641 aatgtgggtg tatgaaaaga agctgcaata ccctgtcaag gtcagtacgt gcaacccgac 680701 gctggcgaag tatttgattg agcagtatgg cggagcggac ggcgagctgg ccgcggctct 680761 ccggtatttg aaccagcgtt atacgattcc tgataaggtc atcggccttt taacagatat 680821 cggcacggag gagtttgccc atttggaaat gattgcgacc atggtctata agttaacgaa 680881 agacgccaca ccggagcagc tgcgtgaagc tgggcttggc gatcattacg tcaatcacga 680941 cagcgcgctt ttttatcata atgcggcggg cgtgccgttt accgcgagct atatccaagc 681001 gaagggcgat ccgattgccg atttatacga agatattgcc gcagaagaaa aggcgcgggc 681061 gacgtatcaa tggctgattg atatttcgga tgatcctgat ttaaacgatt ccctgcgttt 681121 tttgcgtgag cgtgaaatcg tacactctat gcgcttcaga gaagcggttg aaattttaaa 681181 agaagaacgg gataaaaaga agattttcta ataggcagat tggcctctct ttcatacacc 681241 cttttacata cagagaaaat ggtctgtttt tgcagtttgg tctgcattat aatcaaggtg 681301 tgtgtgcaag cttacttttt gattgggagg cctttatgac agcttttaag attgagaacg 681361 aaacgattgc agatggattt tacgcgtgtc cggccgtcta tgaggatgca gaatcgatta 681421 ccgggttgct cgtccgaaca gctgaatggc tccgggatcg gggttctaac caatggagcg 681481 gacttctcaa agggcaagat atacatgata tcacggggtc aattgaaaag ggacatgtgt 681541 ttgtgtttaa aaaagatgaa gagcttgcgg ctgtcgtgat gctgctgcct gcaccgagcg 681601 agtgggaccg gacgctttgg ggagacgatg ggcatgagga gtccatttat ttacaccgcc 681661 tcgcagtaag ccgccggttt gcgggacagg ggcttggagc ccgcgtcctt cagtgggcgg 681721 agacgggcat acactttccg gaaaaaacgc ggatccggct tgactgtgtc gctgatagtg 681781 acgccctgca ttccttttat cggcgtatgg gatatgaatt catgggtgct gatgcgtccg 681841 gatatcattt gtttgagaaa gagattacgg cagaataagc gtcctttgca gggggctttt 681901 ttgtcttttt ctaaaaggga ggcaggcgat gtgtggtcaa tattatttgt gacagggatt 681961 gtgacggctt gtctgtttgc tggcgtatcc gtattgatgc ggatgagatt tcctgacaaa 682021 agtcggccgg aatggatgtt ggccgggctg atcgtccttg gtgtgtttgc gatctggtac 682081 agcctcgtgt atgtacgcgg ctgggaaggg gctgcgctcg gaatgcttgg attcaatgtc 682141 attttcggag ccattgccgg atatttgatc gataaggcca tccggcgtta caggaaaaga 682201 taaggctgct gccgtctctc aacaggtcga aattttcaca gaccggcagg aattttcttt 682261 cgaaaggaga aatacatatt actttaaaat gaaagcgttt tccaaagcag gaaggtgatg 682321 ttgatgatac acagtgtggc aaatgggctg aatcattttt gtacgtgggt gatgagactg 682381 gcctatttga atgtgctttg gattttgttt tctcttgcag gcctggttgt atttgggctg 682441 atgcccgcta ctgccgcgat gtttacagtg gcgagagaat gggcgaaggg gaatacagat 682501 gccccggtgt tttctgtctt ttttcggacg tttaaaaagg aatggcgggc atcacagatc 682561 ctcgggctta tcgttgtgac ggctgccctg tttctgtttg cggatatgcg gatagcggct 682621 cagatggacc agcctgtgct cgtcaatgta ttcgtgagca ttagtttgat tttcgcgttt 682681 gttgtgctgt atgtgttccc ggtattttct cattttgacg taaaaatcag agaggtgctg 682741 agcatcagct ttttcattgc cttcagtcgt ccggcggtga cgcttttgat ggcagcgggc 682801 gctgtcggtg tgctttgtct cgttctgttt catgtcacgt ttctattgtt tttcagcggg 682861 agtttactca gcctgatctt aacgaagctg tcctttaaag cgtttcggtc aatggatcag 682921 cggcaggaga aagaaaaggc ggcatgaaga aaagagttgc tggctggtac aggcggatga 682981 agattaagga taagctgttt gtgtttctat cgttgattat ggccgtatcc tttctgtttg 683041 tatacagcgg ggtccagtat gcctttcatg tgtatgatga gcagatttac cgcaagtcct 683101 cggaggtgct tcggatgtct tctgaaagga tcgaagacga gctgaagaag atagaggatg 683161 tgtcatatga aatcattaca gacgaacaga ttcagcgcat cctgagcatg caaaatcggg 683221 atgatacgta tgatcaatat caaatgaagc aggagctgtg ggatcagctt gcgggatatg 683281 ccagcgatga aaagtacatc gattccattc atgtgattga tgcccgcggc tcagagtatt 683341 cagccggaag cagttcttca gatcttttgc agcaggagca ggaagaggta tttaagcgag 683401 cgaaagcgaa aagtggaaga aatctttgga tgacgctcgg cgggtcagac cccgtcctga 683461 tttcagcacg gcagatcagg tcctatcacc agctgagtct gaacggcttg ggcatggtac 683521 tgatccaggt caatgtaaaa cagatgattc gtgatgtgcc gaaggattgg ggcgattcag 683581 tcggagacat tatgattgct gaccaaggcg gtaatttggt gtatacggca catgcatcag 683641 cgcatgttcc tgaggcagca aaagagacgt tgaagcaccc cggttatgac ttgataaaaa 683701 agaatggcaa acgttacttt atttcttatc ttcaatcatc ctaccaaaat tggagctact 683761 ataacgttat cccctttgat cagatgttcg caaaaatttc ctttatgaaa acagtgatcg 683821 gcacatgctt tcttctcttt ttctgtgtgg ttttgctttt cggaaggaaa atcgccaaca 683881 gcatcacgga gccgattgaa cagcttgtga ccgcgatgaa atcggtacag cacagcggca 683941 ttgaagcagg tgtgtcgctt tctctgccgg aacatacaca ggatgaggcc ggcatgctga 684001 accgccattt tactgtcatg atgaaacgga ttaatgagct gatggaagaa aatgtggaaa 684061 aacagctcat cattaaagaa accgaattga aagcactgca agcccagatc aatccgcatt 684121 ttttatataa cacgctcgag tccatcaatt ggctggccaa ggcgaatcag caaaagcaaa 684181 tctcaaaaat ggtggaatcg ctcggttttc ttctgcgaaa cagcatacat atgaagaagg 684241 atatcgtgac cattcaggag gaggcggaca ttgtacgtca ctatatgacc attcagcgat 684301 ttcgatttga agagcgcctg aaattcacgt tggatattga cgatgaggtg aagcattgcc 684361 tcattccgaa actgacgctc cagccgcttg cggaaaatgc gattcaatac gcgcttgaac 684421 cctttacaag gccatgcgcc atccggattc aggcgaaaaa ggcgaagggc tgtgtctgta 684481 ttacggtcga agataacggc cctggcatgg atggacggat tcttgaatca acgggtggaa 684541 gaggaatcgg actttggaat attcgcgagc gcatcagcct gacattcgga gagccatacg 684601 gattgcggat tcatagtgag catgaaaagg ggacgaggat tgtgatcaca ataccgtgcc 684661 gaaatgaggt ggtgtgatgt ataaaatact gctggctgat gatgagagga ttatccttga 684721 tggaatggcg ggaatcattg agtgggagtc gcttggcgcc tcattgatcg gaaaagcgca 684781 gaacggacat gaagcatatg aaaagattgt acataagcag ccgcatatcg tcatcacaga 684841 cgtcaaaatg cccggcatgg acgggcttga gctgatcaaa aaggtgtcag ccgtcagccc 684901 gtcggtgcaa tttatcgtcc tgtccgggtt tggagagttt gagtacgcaa aggaagccat 684961 gaaatatggg gtgaagcatt atttgctgaa accctgcaat gaacagcaga ttatcagctc 685021 gctggaggaa atcattgctg agctgaagcg gcaagatgtg cacaaaaaga aaacagccca 685081 tctgaaacac gagctggacc atatccgttc ctttgcagcc gatcaatact tggaaggctt 685141 gatcgccggt gtggcccagc tttctccgcc gccttcactt gccggaaaaa agatccgcct 685201 cttgatctta aaaggggaac aatctattga tgctgcagcc agagaggcac tcggatcggc 685261 actgacagcg gtttgcagca gcggtgaatg gaccgtgctc gccgtagagg agaacgccgc 685321 tgaaaaggtg gcggaggttt ttgcggaccg caagatggcc atcagtcagg cgggagaact 685381 ccggcacgcg gggcagctgt ttcgtgacac agctgaagcg tctggtgacc tgcatgggag 685441 cgcagtgatt tcaaaaatga tcaggcttat tgccgacgag ctcggaaatc cgaatctgtc 685501 cttaaaatgg gcggcgaagg atatgctgtt tatgaatcct gattatctcg ggaagttatt 685561 taagcaggaa acaggcgaga aattttccca atatgttaca cgggtgcgtc ttgagcatgc 685621 gatgaagcag atgaaaataa ggagggacgt gagcgtttca gaaattgctg aagaaatcgg 685681 gtttggcgat aatccgaagt atttcagtct tgtttttaaa aaatataccg gtctgacacc 685741 gtcagaattc agaagaaaac agggaggcgc ttccgcagga tagccatctc tgtttttttg 685801 actttcgcca ctgttttttg agtgtttcgc cctatccgaa cgctttaaaa taaaatgtaa 685861 gcacttacat taaagggggg attggtttga agaagatttg ttacgtgctg ttatcccttg 685921 tctgcgtctt tttgttcagc ggatgttcag cgggtgaaga ggcctcggga aaaaaagaag 685981 atgttacact cagaatcgcg tggtggggcg ggcagccaag gcatgattat acaactaagg 686041 taattgaact atacgagaaa aagaatccgc acgtccatat tgaagcggaa tttgcgaact 686101 gggatgacta ctggaaaaag cttgcgccca tgtctgccgc cggccagctt cctgatgtca 686161 ttcaaatgga taccgcttac ttagcccaat acggaaagaa gaaccagctg gaagatttaa 686221 cgccgtatac aaaggatgga acgattgacg tcagttcaat cgacgagaat atgctgtcgg 686281 gcggaaaaat cgacaataag ctttatggat ttacgctagg tgtcaacgtg ctgtctgtga 686341 ttgccaatga agatttgctg aaaaaagccg gtgtgtctat caatcaggaa aactggacgt 686401 gggaggatta cgagaagctg gcgtatgatc ttcaggaaaa agccggtgtc tacggttcca 686461 acggaatgca tccgcctgat attttcttcc cttattattt gcgcacaaag ggtgagcgct 686521 tttataaaga agacggcact ggcctcgcgt atcaagatga tcagctgttt gtcgattact 686581 ttgaacggca gctgaggcta gtgaaagcga aaacgtcccc aacacctgat gaaagcgcac 686641 agattaaagg gatggaagac gattttatcg tcaaaggcaa atcagcgatt acatggaact 686701 actccaatca atatttgggc tttgcccggc tgacagactc gccgctgtct ctctatctgc 686761 cgccggagca aatgcaggaa aaggcgctga cactgaagcc cagtatgctg ttttccattc 686821 cgaaaagctc tgagcataaa aaagaggcag cgaaatttat taatttcttc gtgaataatg 686881 aggaagcgaa ccagctgatt aaaggcgagc gaggcgttcc agtctccgac aaggtggcgg 686941 atgcgattaa accgaagctg aatgaggaag aaaccaacat cgtggagtat gtagaaaccg 687001 cgtcaaaaaa catcagcaaa gccgatccgc cagagcctgt gggaagcgcg gaggtcatca 687061 agctgctgaa agatacgtca gatcagattc tgtatcagaa ggtatcgccg gaaaaagccg 687121 ccaaaacgtt ccggaaaaag gccaatgaga tattagagag gaataattga cgggaaatgg 687181 ggctgacgca atgaaaaaaa gccggagtat aagaaaagac aatctggcgg gatatgcttt 687241 tatttctccg tttatcatcg ggttcctatg ctttacggtg attccgatgg gggcgtccct 687301 gtttctgtcc ttcacgagct atgacttgtt tacggcgccg aaatggatcg ggctcgacaa 687361 ctttaaggaa atgtttacgg gtgacgaaaa gtattggcag tctctgaagg tgacgtttac 687421 gtatgtgctt gccggggttc cgctccgcct cggcttcgcg ctttttatcg ctgtcatttt 687481 aaacaatgca gcaaaaggaa cggccattta cagaacgctc ttttatctgc cttcgatcat 687541 cggcgggagc gtcgccgtgg cgattatgtg gcgcaatatt tttggcaatg acggggtcat 687601 caatgcgctg ctgttttttg tcgggattga tcaaaaaatt ctttggtacc agaatccgac 687661 aagtgcgctg tggacattga ttctgctgtc cgtctggcag ttcgggtcgt caatgctgat 687721 ttttttggcc gggctgaaaa acattccgtc ttcgtatttg gaagcggcaa gtgtggatgg 687781 ggcaaatcgg gtgcagcgtt tcttcaagat cacgcttccg atccttacac cgattatttt 687841 ctttaaccta gtgatgcaga cgatttctgc ttttatgaca tttacacctg cctatatcat 687901 ttcgaagggc gagggcgggc cgcttgacgg gacacttctc tattcgctct atttgttcca 687961 gcgtgcgttt aactattttc aaatgggcta cgcatcggcg atggcgtggg tcatgcttgt 688021 cattgtcggg ctgattacgc tcatattgtt taaaacatcg tcatattggg ttcattacga 688081 gtcaaaggag gaatgacgga tggagccggt caaccagcct gtcagagaag ccccggtttt 688141 tgagagaaaa aaagccgggc gcgtcagtcc caaacgcata ctgttccatg tttttacggc 688201 aacgctggcg gtgttgctgc tgtacccggt tatttggctg tttgtcagct cgtttaaaga 688261 aagcgccagt atttttacaa cctcacattc tctcattcca gaccctttta ttctcagtaa 688321 ctatgctgaa gggtggaagg gcattgcggg acagccgttt ctgacgttta ttaaaaactc 688381 ggcgattatt gtcgggctgt caacaatcgg tgccgtcatg tcatcggctg tcattgcgta 688441 cggatttgcg cgtataccgt ttaagggaaa aaaattttgg tttgcgtgca tgatggggac 688501 gttaatgctg cctcatgaag tgttgatgat tccgcagtat attatgtttg cgaaattaga 688561 ctggctgaat tcctttaaac caattgtcgt tccgcaattt ttcgggcatg cgttttttat 688621 ctttctgatg atccagttta tccggacgat tcccgaggag ctggatgaag ccgcgcgaat 688681 cgacggatgc ggacgctttg cctgcttttg gcggatcatt ctcccgctga ttgcccccgc 688741 gcttgcgacg tctgcgattt tctccttcta ttggaagtgg gaggagctga ttcagccgct 688801 cttgtatttg aataagccgg agctttaccc tgtttcactt gcgctgaagc tttttctcga 688861 tacagagtcg gcttcgaact ggggcgcgat gtttgccatg tcagccgtct cgttattgcc 688921 tgtgattctt gttttctttt tgtttcagaa atatatcgtt cagggcatca gtacgaccgg 688981 attaaaataa aaaggagtgt tgcagatggc acagcttatc tttgatgaag aaaaggtgac 689041 gtcggttatt gaccggatcg tgaaacggac atttcagatg gattttgcgt gggattggcc 689101 gggcggcgtt gcgttttacg gtgtggcgga ggcctatgaa gcgacggaaa acgaggaata 689161 tatcaatctg ttaaaaacgt gggtggatga acagctggag gatgggctgc cgccgctttc 689221 gatcaacgga gtttccattg ggcatacgct tttgttcctc cacaaggtga caggtgatga 689281 cgtgtatttg gaaacagcgg ccgagatggc ggaatatgtg ctgcataagg cgccgcgctt 689341 tggcgagggt atccttcagc atacggtgaa tgcggcagaa tacgtattcc ctgaacaggc 689401 atgggcggat acgctgatga tggctgggct gtttatgctg agaatcgggc gggtcatgga 689461 gcgtgaggat tattttgaag acggcctgcg ccagtttcac ggacatgagg atgtgcttca 689521 ggaccctgtc acgaatttgt actaccacgc ctgggacaac aaagcgcaaa atcatctgtc 689581 ggggatttat tggggcaggg cgaacggctg ggcggcactc acgatggcaa aggcgctccc 689641 gcttattgag gtgacacatc cttcctttat gatcatcgac ggatcgctca gagaccagct 689701 gagcgcgctt gtccggcttc aggatgaatc agggctgtgg catacaattt tggatgatcc 689761 ggattcttat ctggaggttt cggcatcagc gggtattgct tctgctctga tgtcgagcgg 689821 aaagctgtat acaaaatatg tgcagaaatc gcttgccgcc attttggatg cagtggaaga 689881 ggacggacgg gtcagcaggg tatcggccgg gacagccgtc atgaaaaatg ccgaaggata 689941 caaacaggtg ccttacaaac gaatacaagg atgggggcag ggacttgcgc tgacgtttct 690001 tgctgatgtt ttgaaaacga aaaaacgctt gtatcagtaa agatagcggc ggggggagag 690061 ggatgaaaaa acagcctcaa cagaaggaac gggtttctcg ctggaaggga acgtatttca 690121 aaagaaactt tgtcttcatt ttgctgattg cctgtattcc cggattgctg actggcggcg 690181 caatctactt tctttcgatc gacaaggtgg agaaagagct gcagagatcg catgaaacac 690241 aggtggcgcg tgaggtcagc cgaatggatg agaagctggg agtgcttgaa ctggcactca 690301 cccagatggc ctacgattct tcactgatga acggattggc cgagagggat ttggagaaag 690361 actttacgtt ctcctatcaa ttaacgaaaa agctgtttct tttgcgggat cagcagccgc 690421 tgatcgagca ggcttccatc tttctgaaca gcccccggcc acttgtgctg agccctgaat 690481 acagcgcttt gacagaacag gaggcgcttc gcaagtatcg ctcgctgctt gcctcagacc 690541 acagcattta ttggaaacgg tcgggaaacc aagcgatgct gatccagctc attccgggcg 690601 cggcggagaa accgttcggc gcgatcatgc tggcggttga tccgaaagaa atggaatcaa 690661 tcctgcaaag cttgtccccc tatcctgatg gcagtgcgtt gcttttagat caaaatcgag 690721 aggtgctgtt tcatgagggg gaaaaagatt ttgaaaagac tttacttcat gagataaaaa 690781 aacagcctgc tgagaacggc cattttcaga tggaatggaa aggcaaggtg tattctgtct 690841 cctttggaga aatgaaccgg atgcatcagc aatggacctt tgtgtcagcg gcgcctcttt 690901 cagctattac agcgccgatg gtgtttttat caaaagtgat catcgtgatg ctggtcattt 690961 gcatcggttt ggcggtgtgc atgacatggt atgcatcaaa aaaaatctat cgtcccatcc 691021 agcatttgct tggcttgttt accggaggag agaagaaaac atggcaggcg tccgggcagg 691081 atgaattcaa atggattgaa aagagatggc aggatctatc ccttgaaagc cggaagctcc 691141 aacagcagct cctgcggcag acgccccata tgaaaaagag ttttttgcag catctcttac 691201 agagcgattt ttactatgac aacgaggaaa gcctcagatt tcggatggag gaggctggct 691261 ggaacatcgg cggaaacgtg tttcatgtgc ttgatctaca ggtgacaggg ctccgctgtg 691321 aaaaaagcat cttccgtgaa ggtgatgaac agcttgccgt gtttacactg actaatatcg 691381 ctgaggaatt ggcggctaaa cgcgtttttc agctctccat acttgatatc ggccggcttt 691441 ctgtcaccgt tcttgtgatg aaaacaaaca gctctgatct gaaggcgtat ataacggagc 691501 tggcacgcca atttggagat gtaaccggac tatgcctgac ctcgacattg agcagcaaga 691561 cggagcgtgt cacggaaatt ccttctttat ttcaggatgt gaaatgcggc aaatcccgca 691621 ggaagtttgc taaccgggat caggtcattg atttgcaggc cgacttccct cgggatgagc 691681 agttcgctcc ttattaccct tttgagctgg aaaaacaaat tgttcagacc atccggctgg 691741 aaagaaaaca ggaagccaag gaactgatag atggatgtat gaaggaactg tcggaaaaag 691801 cggccataga caggcatgtg cattccgccc tgattcagct gttttcccgc attcaggagg 691861 atattttgca ttccgggctc aatcccagcg aactgtttca gcaccggaat ccgtttcttg 691921 atatttcaga attgcgcgaa cctaacgaag cggcggcctg gctgatggat gtagtggtga 691981 cgccttacct ttccaagctt gagggcagaa aaaacagaca gcaaaagcag ctggcagaac 692041 gtgtgattgc gatgattcac gaacagtata tggcggacat ttcattggaa agctgtgccg 692101 atgcgcttgg catgaattcc tatacgttaa gcaaggcatt taagcaagtg accggcatta 692161 attttatcga ttatgtgacc cagatcagaa tcgaaaaggc gaaagaactg ctggtcaata 692221 cgaataaaaa aattcatgat gtgtctgaag aagtcggcta tcgccacaat tatttcaatc 692281 ggatttttaa aaaacaggtc ggcatgccgc cgggtgtctt caggcaaatg tatcaggaaa 692341 cgccgtgaaa ggagagaaca tgtgatgaag aaaccgattc aagtattttt agcgggggat 692401 tccactgtga gtgactgccc gcctcatgaa gcgccgatgg cggggtgggg gcaggtattc 692461 gggcaattgt tttctgaagg tgtgctggtc cgcaatcatg ccaaaggagg agcgagcacc 692521 aattcttttg tggaggaagg aaggcttcaa gcaattgccg agcacatcac acaaggcgat 692581 tatttgttga ttcaattcgg ccacaatgac caaaaaccgc gggggacgaa gccgtactcc 692641 acatttcagc agtttcttac cttgtttgca gatacggcac gcgaaaaggg cgcgcatcct 692701 gtgttcgtca catcggtgca gcgccgccgc tttgatgaaa acggacggat cgagcatacg 692761 ctcggtgagt atcccgatgc gatgaaagca ctggcgaagg agctcgatgt acctgtgatt 692821 gatctgcttg cgaaaacaaa ggtgctgtat gaagcatacg ggccggagga gtcgaagcga 692881 ttgttcgttt ggtttcagcc gaatgaacat ccgaattacc cggacggcat tgaggacaat 692941 acgcattttt cggaaaaagg tgcaatggag gttgcgaagc ttgtggcaga aggcattgaa 693001 gagctcggac ttccgcttaa ggaccacctt gtgagccggg agggaaaaga acatgtataa 693061 ggaaggcgct tgcttgtacc gcaatccgct ccggtctaaa agcgatgtga aggattggcg 693121 gatggaggga ggcggacaga tctcatttga cgatcacagc ttgcacctgt cacatgtcca 693181 ggatgaagcg cactttgtct tttggtgtcc ggaaaccttt ccagacggca tcattgtgac 693241 atgggacttc tctccgatcg agcagcctgg actgtgtatg ctgttttttg ccgctgcggg 693301 tattcgcggc gaggatttgt ttgacccaag tctcaggaaa agaacaggaa cataccctga 693361 gtatcattca ggagatatca atgccctcca cctgtcgtat ttccgcagaa aatacgcgga 693421 ggaaagagcg ttccgcacct gcaatttaag aaaaagccgc ggtttccatc tcgccgcaat 693481 gggggccgat ccgctgcctt ctccagacga cgctgattct ccgtatcgta tgaagctgat 693541 caaagacaaa ggctatgtgc acttttcaat caatggtctg cccattcttg agtggatgga 693601 cgacggcagc acatatgggc ctgtgttaac aaaaggaaaa atcgggttcc ggcagatggc 693661 ccccatgaaa gccgtttaca gggattttgc cgtgcatcaa gcggtgagaa gatgaagacg 693721 actgtaacgg atgcgcttta tgcaggctgc gaagcggtgg tgaaaatagc atggctcaac 693781 gggctgtggc tgttgtttac acttttgggc ggcgttcttt tcggatgggc gccgagcaca 693841 gctgcgatgt gtgccgttat aaggaaatgg ctgatggggc aaaaggatgt cccgatattt 693901 tcgttatttc tcgataccta taaaaaagag tttctcaagg ttaatgcgat cggattggcg 693961 ttttcggctc ttttgctcat attgtctgcc aactatcatt atttttctgc cagtacgaat 694021 tggctgtcct ttgccgtaac aagctgcacg ctgcttgcag ggcttttgta tatcatcgcg 694081 ctgatgtatg tgtttcccct ttatgtgcat taccagctcc cgcttcgcaa atatattccg 694141 caggcactgc tgtttggcgc catgagaccg ctgacaactg gctgtatgct gatcgggtgc 694201 ggatttgtcc tttatttgct gtatacgctt cctggcctga tcccatttta cggcccgtgt 694261 ttatttgggc ttgtgttgat gttttttgct cttaggggat ttcaaaagac ggaggcccag 694321 caccatcaag ccgggtaaca aaaaaatgac aaataagcaa aaaagtgcag tgtccgaaat 694381 aggcagatgc aaaaaagtga aattgaagac agctcacaaa gcgcataaaa tccaatttaa 694441 gtaagcgctt acagataaat gagaaggagc tgtctgatga ttagacgaag gaaacgcatg 694501 tttaccgctg ttacgttgct ggtcttgttg gtgatgggaa cctctgtatg tcctgtgaaa 694561 gctgaagggg cagcgcggca gatggaagcg ctgaaccggg ggcttgtagc ggtcaagacg 694621 gacgggggca tttttgtcag ctggcggttt cttggaaccg aaaacgcatc tgttttgttc 694681 aatgtgtaca gagacgggca aaaactgaat gctgcgcctg tcaaaacaac gaactatgtg 694741 gataaaaacg gttcggcggg ctcaacgtat acggttcggg ctgttgtaaa cggtaccgaa 694801 cagccggctt ctgaaaaagc ctccgtatgg gcgcagccgt atcattccgt cccgctggat 694861 aaaccggctg gcggcacgac gccaaagggt gaatcttaca cgtacagcgc taatgacgca 694921 agtgttggcg atgtggatgg tgacgggcaa tacgagctga tcctgaaatg ggacccgtcc 694981 aactcaaaag acaattcaca ggatggctat acgggtgacg tgctgattga cgcgtataaa 695041 ctggacggca caaagttatg gcggatcaat ctcggcaaaa acatcagagc gggcgcgcac 695101 tacacccagt ttatggtgta tgaccttgat ggtgacggaa aagcagaagt ggcaatgaaa 695161 acggcagacg ggacaaaaga cggcacgggc aaagtaattg gaaatgccaa tgcagattac 695221 agaaatgaac aggggcgtgt gctttcaggc cctgaatatc tcactgtgtt tcaaggttca 695281 accgggaaag agcttgtcac cgcaaatttt gaaccggcgc gcggcaatgt gtcggattgg 695341 ggagacagct acggcaaccg tgttgaccgt tttctcgccg gcattgccta ccttgatgga 695401 cagcggccga gcctgatcat gaccagaggg tattacgcta aaaccatgct agttgcctat 695461 aacttcaggg acggaaagct gtcaaagctt tggacgctgg actcctcaaa gtcaggaaat 695521 gaagcgtttg ccggacaggg gaatcacaac ctgagcatcg cggacgttga cggggatgga 695581 aaagatgaga ttattttcgg ctcaatggct gttgatcatg acgggaaagg catgtactcg 695641 accggcttag gccatgggga tgccctccat acaggagatc ttgatccggg ccggccgggg 695701 cttgaggtgt ttcaagttca tgaggacaaa aatgcaaaat acggcttatc tttccgggat 695761 gctgcaactg gaaaaatcct ttggggcgtt tatgccggca aggatgtagg ccggggaatg 695821 gctgctgata ttgacccgcg ttatccggga caggaggtgt gggcaaacgg ttctctctac 695881 tcagcgaaag gggtcaaaat cggaagcggg gttccgtcct cgaccaactt cggcatctgg 695941 tgggacggcg atctgctccg ggaacagctg gacagcaacc gaattgataa gtgggattat 696001 caaaacggcg tatcgaaaaa tatgctgact gcatcaggcg cagcggctaa caacggcaca 696061 aaagcaacac caacgcttca ggctgatctg ctcggtgact ggcgcgagga agtggtgtgg 696121 agaacggagg acagcagtgc tctgcgcatt tacacgacga ccattccgac tgagcacagg 696181 ctgtatacgc tgatgcacga tccggtgtac cggcttggca tcgcctggca aaatatcgcc 696241 tataaccagc cgccgcacac aagcttcttt ttaggagacg gcatggcgga acagccaaaa 696301 ccaaatatgt atacgcctta actgaaaggg ggaaggaacg ggctgcgcgc agcccgttcc 696361 catcaaatga aaccaaaaaa gaggcaaatg gaatacctga ccagaggttt gattgcggta 696421 cagacagaac agggcgtgtt tgtcagctgg cgttttctcg gcacggatca tgagacgacg 696481 gcttttcacc tttatcggga tggaaagcgg atcacccgcg atccaatcgc tgaaagcact 696541 aattttctcg atcaaaacgg aacggctgac tctgtttatc aagtggcggc tgtcaataaa 696601 ggacgggaag aaaagctttc caagaaagct cgtgtttggc aggaaaatgt cctggaggtt 696661 cctcttgcca aaccggaagg cggtgtgacg ccggacggaa agccgtacac ttacagcgcc 696721 aatgatgcca gtgtcgggga tatagacggg gatggagaat atgaaatgat cctgaagtgg 696781 gacccgtcca attcaaaaga caacgctcat gacggttata ccggggaggt gctcatagat 696841 gcctataaac tggacggcac ctttttgtgg cgcatcaacc tcggcagaaa catcagagcg 696901 ggtgctcatt acacgcaatt tatggtgtat gaccttgacg gtgacggaaa agcagaaatc 696961 gccatgaaaa cagctgacgg cacaacagac gggaaaggac atatcatcgg tgatgagcag 697021 gccgatttta gaaacgaaca gggcagaatt ttgtccggtc cggaatattt gaccgtgttt 697081 aaaggagaaa ccggtgaggc gctcacgacc gtggaatatg aaccgccccg cggcaagctg 697141 gaggattggg gagacggcta tggaaaccgg atggaccgtt ttctcgccgg gaccgcttat 697201 ttggatgggg agcggccgag ccttgttatg gcgcgcggct actatacgag aaccgtgctc 697261 gtggcatacg atttcagaaa cggaaggctc aaaaaacgat gggtatttga ctccaaccag 697321 ccgggacatg aagcatacgc aggacagggg aaccacagct tgagcgtggc ggacgtcgac 697381 ggagacggaa aggatgaaat catatacggc gcaatggctg tcgatcatga cggaaccggc 697441 ctgtactcaa cgggcctcgg gcacggagac gcgatgcatg taggggatct ggacccgtca 697501 cgaaaagggc ttgaagtgtt ccaggtgcat gaggacgcca cgaagccgta cggactgtcg 697561 ctgcgagatg ccggaaccgg tgagatatta tggggcgtcc atgctggaac tgacgttggc 697621 cggggcatgg cggctcatat tgatccaagc tacaaaggat cgctcgtctg gggaattgat 697681 ccgccgggca atgatggcat gtcgtacggg cttttcacga gcaaaggcga aaaaatcagc 697741 gacaaagcgc cctcttcagc caatttcgcc atctggtggg acggtgattt ggtcagagaa 697801 ctgcttgatc atgactggga cggaacgatc ggcaggccaa agattgaaaa atgggatgct 697861 gaaaacggct gtctgaagac gatatttcag ccggccggcg tgttgtccaa caacggcacg 697921 aaaggaaacc cggttcttca ggccaacctg ttcggagact ggcgggaaga agtgatatgg 697981 agaacggaag acagcagcgc gctccgtatc tatacaacaa cacatctcac ccgccactgc 698041 ttttacacgc tgatgcatga tccggtttac aggctcggca tcgcctggca gaataccgcc 698101 tacaaccagc cgccgcacac gagcttttac ctcggaacgg gaatgaaaaa accgccgaag 698161 cccgccctgt acatagcggg aagcaaagcg gaggcgccgc tgtaggagga ctaagggata 698221 agacgcaaag gctgaacgct acgccaagat gattagagaa ctggcaggac gaaccaatgc 698281 tcaagcgctg tacgcaccgg ttttttcaag ggaagagcta tccgtgatgg aagctgtata 698341 aaaaacgagg aggaatgaaa aaatggcaaa tcatatttat cttgccggcg attcgactgt 698401 tcaaacgtat ggagacagca caaatcaagg gggctggggg cagtttctcg gctcgcatct 698461 gccggagcat attcaagtga tcaacagagc gatcggggga agaagctcga aaacatttgt 698521 ggaagagggc aggcttcagg caatcctcga tgtgattgag ccggatgatt ggctgttcgt 698581 gcagatgggc cataatgacg cgtcaaaaaa taagccggag cgctacaccg agccctatac 698641 tacttataaa caatatttaa agcagtatat cgcaggcgcg cgggaaaaag gcgcccatcc 698701 gcttctcatt acccccgtag cccgctttca ttacgaaaac ggcgtgtttt tgaacgattt 698761 tcctgattac tgcattgcca tgaagcagac ggccgctgag gagaatgtcc agctcattga 698821 tctgatggag aaaagtctcg ctttctttac tgagaagggc gaggaaaaag tgtacaccta 698881 ttttatgatt tcagaaggga ttaacgatta cacgcatttt acaaaaaaag gcgcaaatga 698941 aatggcgaaa cttgtggcaa aaggcataaa ggagctcggc ctgccattga cagaatcgat 699001 catcaaagaa aggtgaaaat gtgatgagaa aactgtatca tggcgcttgc tattatccgg 699061 aattatggga tgaagagacg attcagcagg acattgacat catgcgtgaa gttggcgtaa 699121 atgttgtgcg gatcggcgaa tttgcctggt cagtcatgga acctgaagaa ggaaaaattg 699181 acgtcggttt tttcaaagaa atcatcgccc ggctgtatga tagcgggatc gaaacgatta 699241 tgtgcacgcc gacgcctacc ccgccgattt ggttctcaca tggccggccc gaacgcatgc 699301 atgccaatga aaaaagagag atcatggggc atggctcccg tcagcatgcc tgtacgaaca 699361 acccgtattt ccgaaaaaaa gccgccatca tcaccacagc catcgccaag gagcttggcc 699421 ggctcccggg gctgatcgga tggcagctag acaatgagtt taaatgccat gttgcagaat 699481 gcatgtgtga gacatgcttg cgcctatggc atgactggct caaaaatcgc tacggggtaa 699541 ttgagcgctt gaatgaagct tggggaaccg atgtgtggag cgagacctat cagacgtttg 699601 agcaagtccc gcagccggga ccggccccgt ttctgcatca tgcctctcta cgcactatgt 699661 atcagctgtt ttcgatggag atgatcgctt cgtttgcgga tgaacaggcc aaaatcatcc 699721 gctgctattc agatgcgccg atcacgcata acggatcagt catgttcagc gtggacaatg 699781 agcgaatgtt tcagaatctc gattttgcct cctatgacac gtacgcttcg caggaaaacg 699841 cctctgcctt tttattgaac tgtgatttat ggagaaatct gaaacaaggg cgcccgtttt 699901 ggattttgga aacgagtccg tcgtatgccg cctcgcttga aagctccgct tacccgcacg 699961 cagacgggta tttgcaggcc gaagccgtat cgtcctacgc cttagggagc caggggtttt 700021 gctactggct atggcgacag cagcgttcag gcagcgagat ttcccacggt tcggttctca 700081 gtgcctgggg cgaacccacc atcggctatc aaaatgtgct ggcggttgag cgggcaagaa 700141 aggaaatcga gcctattatt ctatcgactg aacccgttca agccgaggcg gcgatgactt 700201 actctgacag agcaaaagca tttattaaaa ctgagcctca ccggggactc cggcatcgtt 700261 cgcttgtgac gcatttttat gaacgtattc tcaacacggg gattcaccgt gaccttattc 700321 cggaaggcgc tccactggac ggctatcgct tgctgtttac gccatttgtg ccgtatttgt 700381 cttctgaatt tatcaaaaaa gcttcggcat tcgctgaagc gggcggcatc tggatcaccg 700441 ggccgctgac aggaggacgc acatgcgagc ataccattca taccgattgc ggacttggcg 700501 aacttgagaa aacgtcaggg atcaaaacac tttttacctt tccgatgaat gagaacgtga 700561 atacaggaaa agcgtttggc atcacggcgc cgctcggact gtggagcgcg gtgtttgaca 700621 cagagagcgg aaacaccctt ggcacggttg aagcaggacc gggggcgggc catgcttttc 700681 tgacggaacg gaattacggc gaggggaaaa ttgtcatgct gggctcgctt ccatccggga 700741 aagaagggga tgcgatgctg gaagcgctcg tcaggcatta tgcggaggaa gctgttattt 700801 ccagccggtc ggatgtgaca cccggcacga tcgttgcccc gcgtataggc gaaaacggcc 700861 ttgtgtggat cgttgtgaat atggatggaa aaggcgggag cgtgacattg ccggaatcgg 700921 gaacggattt gttgacgcac cgcttggaaa aggcggggag actggcggtc ggaccgcatg 700981 aataccgtgt gattcaattt gacaatcaca gctgattctt tgtatcgaat cagctttttt 701041 ctatggaggg agagacagat gaaaaagatc aaatggttat caggacagcc aaaggtgaca 701101 agcggcgtga cgtggggcat gccatggaaa aaaggagaat taaaaaaagg agaccgtctg 701161 gcgcttatga atgaaaacgc ggaaacgcga tatgtgcaaa gcgaaccgtc ggcctattgg 701221 ccggacggga gcatcaagtg gacgaagcac gcggcggtgt ttggcggtca ggaaaaccaa 701281 agctttacag tgcacaaaag agaagtgccg cagccaactg aatcgctcag cattcttgag 701341 acagagcatg atatccaagt ggatacagga gcactcgttt gtaccattca taaaacagga 701401 tctgatttca ttcaatcatt gcagatcaat ggaaagccga tcgccgcagg cgggaggctc 701461 gttgcgataa gagaaacgag aaaagagtca gcggcgaaaa tggttctttt gcatgaaagg 701521 tctgtcagct ttatcaaacg ggcggcgatt gagcagagtg gtcctgtcaa agcagtagtc 701581 aaaatcgagg gagtgcatgt gcttcataaa acgtatgagg aatggctgcc gtttgtcatc 701641 cgattaacgt tttatgccgg gctgtctgag atcggccttg tgcacacgca gctgattgac 701701 aggagcggta aactagaatt cgttaagggg ctcggcatcg aattcgacct ttttttggag 701761 ggagagccgt acaaccgcca tttccgcttt gcgggagaga aagggatgta taaagaaccc 701821 gcccagctgt ttggcacacg taaattcaat gaacgatatc cgctttatga aaaacaaatc 701881 aatggcgaaa tgctgtctcc agatgaagag cataaggaat ggtttgcaca tggcacacag 701941 aatgcggttt gggacgatgt caagatcgtg caagattcca gcgatcatta cagcctgtca 702001 aaacggaccg gaaaagatta tgcgtgggtt ggaatgctgc atggcagccg ggcgaagggg 702061 ctctgctatg cgggcggaaa aaatggcggt gtggctctcg gcctgcggta tttctttgag 702121 aaatatcctt cagcactgga aatcacaggt cttgccggca gccgccccaa aatgactatc 702181 tggctttggc ctccggacgg cgaagcgatg gatttgcggc attatacagg aaacactcac 702241 gtggccagcg cgtatgaagg ctttgatgaa atgcgctctg atccgacagg cattgcgaac 702301 acaaatgaaa taagcctggc gtgcttttcg cacatgccgt ctgacgaagt cctcaatgcg 702361 ctggctgaca aatggcaggc gcccccgctc attgtatgcg agccggacgt ctattacgaa 702421 tcaaaagcac tcggggtatg gagcatcatt gacacatccc atccgctcaa aaaagagctg 702481 gaagaacagc ttgatgcggc ctttctgttt tataaaaagg aagtagagca acgcagatgg 702541 tacggttttt ggcattatgg cgatgtcatg catacgtatg acccgatccg gcatatgtgg 702601 cggtacgatc tcggcggata cgcatggcaa aacaatgagc tcgttccgac cctatggctg 702661 tggcaggcgt ttttccgctc aggcagagag gatatcttcc gaatggcaga agccatgacc 702721 cgccatacga gtgaaacgga cagctttcac ctcggtgaat atgccgggct tggctcacgg 702781 cataatgttg tgcactgggg atgcggctgc aaggaagcga gaatcagcat ggccgggctt 702841 cataaattct attattatct gacgggtgat gaccggacgg gagatctttt gacagaagtg 702901 aaggatgccg attatgccct tgtcaaaacc gatccgatgc gcgcttttta cgagaaaggc 702961 aagcacccga ctcacgccag aacgggaccg gactgggcgg cgttttgctc gaactggctg 703021 gcggaatggg agcggaccga aaattcggaa tatctcaaaa aaatcgaaac gggaatcaac 703081 tgtctgaagc ggctgccgct ccgcttatta tctggcccga catttgaata tgatccggcg 703141 acctcgatgc ttcatcatat gggagacggc attgcgggcg gatatcatat gatcattgcc 703201 ttcggcgcgc cgcaagtgtg gatggagctg gctgagcttc ttgatgactg ggaatgggag 703261 gatatgctga gtgaattcgg cgaattttac acactcagtg atgaggaaaa acgaaaaaaa 703321 agcggaggcg ctcttcatga cgggcatttt cactggccga tgttcgccgc cggtatgaca 703381 gcctacgccg caagaaaaaa gcaagatcct catctcgccg ccaaagcgtg gaatcttttg 703441 ctagaagata agctcagcca tacgccgctt ccgatcaaac cggagcgcat cgagacatgg 703501 acgcagctag aggagcttcc atgggtgaca acgaacactg tctctcaatg gtgtttaaat 703561 gtcatagcgg cgctggaact gatcggagat tcccttccgg caaaaaaaga aacatcgggc 703621 aaaaaaggat aacagccgga atttcatagg agaaatggtg caaaaaatga agattgcaag 703681 aatttatgta agcgctttat attgagaggg gcaaagggga aatgcaaatt gaaaaaaggg 703741 ggacttacgc aacatgaaaa taagaatgcg aaaaaaatgg atggccttgc cgcttgctgc 703801 catgatgatc gccggatgca gccattcgga aacatccaat tcagcaagcg gttcgaaaga 703861 tacgatcaaa attatggcgc cgctcttatc gccggaaagc ccaagtgata agagcccttc 703921 attaaaagcg ctcgaaaaat acacaggcaa agagattaag gtcacatggg tgcctgattc 703981 atcctacaac gacaaattca acatcgtcat ggcttcagga gagatgcctc acgcgattgt 704041 cattaaagat aagtcagccg gctttatcaa atctgtcaaa gcaggggcgt tttgggagct 704101 gtctccttat ttaaaagact acaagaattt aagccaggca gatgaaaaga ttttgaagaa 704161 cagctcggtg aacggcgagg tgtacggaat ctacagaacg agggatctga tcagggcgtg 704221 tatgatcatc agaaccgact ggctgaaaaa tgtcggtctg gatatgccgg aaacgcttga 704281 tgatttctat gaagtgctga aagcctttaa ggaaaaagat cctgacggaa acggcaagga 704341 tgatacgtac ggcatggtcg tgccgaaatg gatgggactc ggcaacggaa gcccatggga 704401 tgttctgcaa atctggttcg gcgctccgaa ccgctacggt gttgaaaacg gaaagctgat 704461 tccagatttt acaacgaagg aatacatgga tgcgctcacg ttttttaaaa agctctatga 704521 tgagggcttg atcaataagg actttgctgt catggattct gcgaagtgga atgatccggt 704581 tgtaaaagga aaagcgggtg tcatcgttga tacaggctca agagcgtctc aaatccaaag 704641 cgcgatggag gaggcggatg agtcgaacaa ggatatcatt gatatcgtcg gctcgcttga 704701 gggaccgaat ggcaagcgca ccttcccgac atctggttat tcaggcatga tcacgatacc 704761 aaaatcaagc gtcaaaaccg aaaaagagct gaaagaggtg ctgtccttcc tcgataagat 704821 gaatgataag gaagcgcaga ttctcacgaa caacggagtg aagggccgca attacgagct 704881 caaggacggc gtattcacct cacttgaaaa aaacaataaa tctctcctgt atgagcatga 704941 aggcttggca cagttcagca tgtcgattcc gaaaagcgag tattacatcg aagaccagaa 705001 aaccaagctc ttccagcatc gcaaggacat cataaccgaa ggagaaaaaa tagccgtctt 705061 taaccctgct gagtcgcttg tatctgatgt ctatacccaa aaaggagccc agcttgacaa 705121 catcatcctc gacgcgagaa cacaatttat cattggagaa attgatgaaa aagggttcga 705181 tgatgcggtg gagctttgga aaaaaagcgg cggcaatgaa ctgatgaagg acttgaacaa 705241 attgtaccaa tcgtcaaaat aaaccgatgc gcctgccttt cggcgggcgc cccggtatca 705301 cgaaaggaga acagatatgg aaacagtgcc gaagaagaga gatgcacctg ttctcaccgc 705361 tggaaaaggc atcagctgga tggctgcgct caaacgggac aaatggcttt atcttcttct 705421 tattcccggt ctgctttatt tcttgatttt caaatacttg ccgatgtggg gtgtgctgat 705481 cgcttttaaa gactattcgc catatctcgg cttctggaaa agcgaatggg tcggctttga 705541 ttatttcaaa gactttttta tgaatccgga ttttttccgg ctgctgcgca acaccctcat 705601 gctggcgagt ctggatcttt tgtttgcctt tcccgcgcct ctcattttgg ctctgctttt 705661 gaatgaggta agaaaggccg tgtataaaag atgtatccaa acctttattt acgtacccca 705721 ttttgtatca tggacaattg tggtcagcat caccttcgtt ttctttactg tcgatacagg 705781 tgtgatcaac aaattgatta tgagcctgac aggtgagcag atttctttct tgtcggatgc 705841 agactggttc cggccaatga ttgtgatgca aagcatttgg aaggagacag gctggggaac 705901 gattctattt ttggcagcgc ttgctacggt tgatcaagag cagtatgaag cggccatcat 705961 ggacggagcg gggcggttca ggagaatgtg gcatattacg ctgccggcga ttagaagcac 706021 cattatcgtt ttgttgattt taagaatcgg cagctttttg aatcttggct ttgaacaggt 706081 gtatttgatg acgaactcac tcaaccgcag tgtggctgac atcttcgaca cgtatgtgta 706141 catgatgggg attacccaag gggcgtatag ctacagcacg gcggtcggtt tgtttaaatc 706201 agttgtcggg attatcttga tttttggcgc caattacatt gcgaaaaagt ttgatcagga 706261 aggattgttt tagaggaggg agaggtatgg ctgaaattca cacgatgcac aacaccaaag 706321 ccggacgggt gtttgacgtc tgcaacattc tgtttctcgg cggtgtcggc gcgattacca 706381 ttttgccgtt tttatatatt atcgccggtt cctttgcgac agaagcggaa ctcgcccagc 706441 ggagcttctt tattttcccg aaaaccttta cacttgatgc ttacaagtat gtgttttcga 706501 caccgacgtt ccttcgaagc atgggcgtgt ccatcttcat cacggtggtt gggacggctg 706561 tacagctgtt ttttaccttc acgatggcgt atccgctggc gaaacggcat gtgaagggac 706621 ggaatctgct gttgaatctg gtgattttct ccatgctgtt ttcaggcggc atgattccga 706681 cgtaccttgt cgtaaaatca cttggccttt tggatacgta ttgggcattg attctgccga 706741 tggcgattaa tccgttcaac cttattatta tcaaaaactt ctttcagcag ctgccgcgcg 706801 agctggagga atcagcaaaa attgacggct gttccgaaat cggcgtcttc tggcggatcg 706861 ccctgcctct gtcaaagcca gttattgcga cctttgcgct gttttatgcg gtcgggattt 706921 ggaatgattt cttccacgct ctcttatata tcaatgacag tgcaaaatgg ccgctgcaaa 706981 tggtgcttcg ccaagtcaca attttatcgg atttaacggc gaccaatggt gatacgatgc 707041 aaaatgcagt tccgccggag cagggaatta aactcgctgt cattgtcatt gcgacgctgc 707101 cgattttggc ggtctatcca tttttacaaa aacactttgc aaaaggaatg ctgatcggtt 707161 cggtgaaagg ctgagaaagg gagtgtttca tatcagtaca ttagatcaga ttaagattgc 707221 ctatatcggc ggggggtccc aaggctgggc cagaagcctg atgagtgatt tgtcgattga 707281 tgaacggatg tcaggcacgg tggcgctcta tgatcttgat tttgaagccg ctcagaaaaa 707341 tgaagtgatc ggcaatcaca gcgggaacgg cagatggaga tatgaggctg tttctacttt 707401 gaaaaaggcg ttatcagccg cggatatcgt cattatttcc attttgccgg gatcactgga 707461 tgatatggaa gtcgatgtgc acttgcctga gcgctgcggt atttatcagt ctgtaggtga 707521 tactgtcggg cctggaggga tcatcagggg cttgcgtgct gtgccgatat ttgcggaaat 707581 tgcccgggca ataagagact acgcacctga atcatgggtc attaattata caaacccgat 707641 gtctgtctgt acaagagtgc tgtataaagt gtttcccggc atcaaagcga ttggctgctg 707701 ccacgaggta ttcgggacgc aaaagctatt ggcggaaatg gtcacggaaa ggctggggat 707761 tgaggtgccg cggcgtgagg atatccgcgt taatgtgctc ggcattaacc attttacatg 707821 gatcacaaaa gcctcttacc gccatattga cctgttgcct atattccgtg aattcagcgc 707881 gcactatggg gaatcaggat atgagctgga gggggaatgc tggagggaca gcgtcttttg 707941 ttcggcacac cgtgttgcgt ttgatttatt tgaaacgtat ggcgccatcc ctgctgcggg 708001 tgacaggcat ctggcagagt ttcttcccgg cccatacctc aaacagcctg aagtatggaa 708061 atttcatctc acacctatat cattcagaaa acaagacaga gctgagaaac gacaagaaac 708121 agaacggttg atcgtgcaac aacggggcgt tgctgagaaa gcttcgggag aagaaggcgt 708181 gaacatcata gcggctcttc tcggattggg tgaactcgtc acaaatgtaa atatgccgaa 708241 tcaaggccag gtcttaaacc ttcctataca agccattgtc gaaacaaacg cattcatcac 708301 aaggaaccgt gtccagccga ttttgtccgg agcgcttccg aaaggtgtgg aaatgctggc 708361 ggctaggcat atatccaatc aggaggcagt ggcggacgca ggtttaacaa aggatactgg 708421 cctcgcgttt caagccttcc tcaatgaccc gcttgtccag attgaccgca gtgatgcaga 708481 gcagcttttc aatgacatgc tccaatgcat catgcaaagc tgagcttgcc gattagctct 708541 ttccggttta gaaaggaaag cattgaccat actgatagta taatcaagaa gtaggtgcta 708601 tcaatatggg aaattattta agtgttgcgg tagaactggt ctgcggttta ggcattttat 708661 ttatcatctt aaagcttctc gggaaaaccc aattttctca aattacgccg tttgacttta 708721 tttctgcttt aattttaggt gaattggtcg gaaatgccgt ctacgatcat gaaatcaaaa 708781 tcaaagaaat tatttttgct tcgctattgt ggggcgtgct gatttatatt attgaattta 708841 tcacgcaaaa aatgaaatca tcgcgaaagt tcttggaggg cgagccgaat atcgtcatcc 708901 gcaaagggga gcttcaatat aaagtaatga agaaaaataa gatagacatt aaccagctgc 708961 aaagcctatt gaggcaagct gggagctttt cgatccaaga agtagaatat gcgattcttg 709021 aaacaaacgg gatggtcagc gtgcttccaa aatcagactt tgacaaaccg acaaataagg 709081 atttgcagat tccttcgaag tccgtttctc tgccgatcac gttaatcata gatggagaga 709141 ttgtgcggga taatttgaag gaagcaggtg tggatgaaca gtggctgaaa caagaattga 709201 aaaagaagaa cattgataag acagaggacg tgttatttgc agaatggcat aaaaataagc 709261 cgctgtatac tgtaacgtac gaacaaagca gatcaacatg actcttagaa aaaagcttgc 709321 agcaaggcgc aagcttttta ttgattgtat gtcccttgtt tgacagcacg tacatggtac 709381 atgctcactt cagtgctgat cagatagtca ggctttggtt tgcctttgtt tgctttatgg 709441 ccggcgatat gcgcatcgct tttttcccat tgcttccagt gatcctctga ttcccagcga 709501 atcatgacaa caacttcttc atcaccgcgg cgcacatttt tctcaagcac tgtcacatca 709561 attaaacctt cttgtttttc aatgattcct tcagcgctga aacgttctat gactttatct 709621 gcaaagcctt ctttaaccgt catttttctc aactgtacaa acatttgtct cactccaatc 709681 attctcacat atgaataatt gtaaatgaaa ttcattctca atgtcaaaga aagcgcaggg 709741 cggaatcgaa ccgccgtgcg caacagttta ttcttttaat aaaaacacat ttccgtcttc 709801 gtccttaaat tgaacgaagg tgccccactc catttgattg ggctcaccga gaaattctac 709861 accgtttgtc ttcattttct cgtatgtacc aaagatgtct tcgcattcaa acacaataga 709921 agccttcatt tgctctgagc ctttcatcat ggctttcggg taaatgacta aacgagtctc 709981 ggctcctttt ggcgcaacct ccagccagct tgcttcaggt cccattgggt gatccgctgc 710041 aatatcaaag cctaccttct ctgtccaaaa ttgcttcgct ttctgctggt cctcgacata 710101 tacagcaaca gtgccaattt gtttgatcat agggaaacct ccaagttgaa aagataataa 710161 tactataacc tgtttacggc cgaagtaaca taaaaaaatc agccgggaaa ccggctgatt 710221 attaaaatga gcagcttaca acatcgatgt gatttgtgtc taaggcgaaa taaacccagc 710281 ggcgccgtga ggaatcccaa taaaagccgc cgacggatct tctgccaagg atgatcgggt 710341 aaaaccaaaa tgagcggcca ttggttaacc agacataggt aaatcggaaa aggcaaggac 710401 gaatggtgat tggttcaact aacaaaacgg ctccttgaga accctgcggt tttgggggtt 710461 tcgctggtat ttgggaagga ggaggtccct gcggcgcacc gccgaagcct gggctggcac 710521 cgctgccaat accagggccg gagccgccgc caaagcctgg aacagcacca ccgccaatgc 710581 caggaccgga gccgccgcca gagcccggaa cagcgccgct gccaatgcca ggccatggat 710641 atcggtattc atattcaaaa gcaggccaag gctcataaaa atgccccgca aacatataag 710701 gatcaacata atacatgtga taacgtcctt tctcattgta aactgtacat tgcagtttat 710761 gcgggcggac tcttattggt gcattcgcct aaggatatga agctggaatg ctctcagaga 710821 gcagaatcat ttgatttttc tctagtctta ttcacaattc cgatttatca ttttataatg 710881 aaagtgcttc tattacgaaa aaggagacag accgtgaata tcgatcaatt attatatcaa 710941 tatatcatag acaacactgc ggatattact gagaaatggt tcagtttgcg ttgccagcta 711001 aaaggcgagc tatattccgc cagccattta agtgaagaaa cgaaaacact tttaaccgag 711061 cagcatacat ttaccaatat aacaatcgca agcgcatttc tggaggatca aaccgatttt 711121 caagaaaaca tgacaaaatg ggcgcaaaac gttgcgaaaa acagggtaga gcaggatgtt 711181 caagtgcatg aggtcgtaga agccatatcc aattcaagaa tctcattctg ggacgcagtc 711241 gccacattta taaaagagaa tcaggagatt gtgacaaatg aggatgcaga ccgatggaac 711301 cgcattgtga atcagtcgtt cgataagctg attattgaat tctccgagca gtaccaaaaa 711361 ttcatgctga tgaggcttac atctcagcag gaactgatct cagagcttgg ctgcccggtc 711421 atttccattg ccgatggaat cgggatattg ccgcttatcg gctccattga tacaaaacgg 711481 cacaggtcat tttagaaaca gtgccggtcc gctgtgtcga gagaaaaatc acaagcctcg 711541 tcgttgatct ttcgggtgtt ccgattgtgg ataccatggt ggctcagcaa ttgtacaacc 711601 tgtctaaaac acttttctta ttaggcgtca aagccgtatt ttcaggaatt cgcccggatg 711661 tggcccaaac atcgattcaa ttggggcttg attttagtga atatgaaacg tacggcacgc 711721 tgaagcaggc attagaaaac atgggtgtcc gctgtattgt tgaggaattg gaagaaaaca 711781 aataggaagt ttccaggcat atgattgtcc gtcaccgggt gatcatatgc ctttttgatt 711841 tgaacagaaa tcaccattga tttatcgaaa aaaacataat attataattc ttataagaat 711901 actgtgaatt aaaacctatt caacaggggg gaaggtcttt tggtttctaa atcaacgatt 711961 gatccggaag tgattgaaaa aatcatcagc tcgctggaaa cactcgattt cggcacggtt 712021 cagattacgg ttcatgattc tcagattacc caaattgaga aaatagaaaa gcaccgtttt 712081 tcgctgaaaa ggaaagaatc aaaatgataa tgtaaagggc gtttgttttc attaaattct 712141 ccttaaaaca tatacatatt tcatccaatt tttatataat agacctttaa gatcattttt 712201 taggaggatt tttgacatgc aagctacggt tcacgagagt aagcaatcga tcatgcaacg 712261 cattttgaca gtctttgtct tcacattgct gatcgcgact gtcggccttt ttatcggcca 712321 atttgttcct gtcgctttga tgctgccgct ttctattctt gaagtggcga tgattattct 712381 ggccttctgg atgcgcagaa gaaaagcggt cgggtatgcg tttgtatata cattcgcgtt 712441 cgtttccggc attaccttat ttccgatcgt cagccattac gcttccatcg ccggcgccta 712501 tgtcgtgctc gaagcctttg gctctacatt tgtcattttt gccgtcttgg gcacaatcgg 712561 cgcaaaaatg aagaaggatt tatccttcct gtggtcgttt ctgctggttg cggtgctcgc 712621 actcgcagtg gtagggattt tcaacatttt cagcccgtta aactcagcgg cgatgatggc 712681 gtattccgtg atcggaacca tcgtcttttc cctttacatt ttgtatgatt tgaaccaaat 712741 caagcaccgc cacattacgg aagacttgat tccggttatg gcgttatcgc tgtacctaga 712801 ctttatcaac ttgttcatca acctgctccg cttcttcggc attttgagca gtgatgatta 712861 atgaaaaagc gtctgtcatt ggataggcgc tttttgccat acatcaaaaa ggcaggtgga 712921 gtattggtga aaaaacaaat gggcgcatat gtatctctgg cagcagctat ggcgatcgtc 712981 ggcagttctg tcgttgtcgg caagctgatg gtcgaacgga ttccggtctt tctttcctca 713041 ggattgcgtt ttttgatcgc ttctgtcgta ttgctcatgc tgctgttttg cattgaaaaa 713101 gggtttccgg ctttgacgaa aaaagatgtg ttcgtattac tggtgcaatc attcacaggc 713161 gtgtttttgt tcagtatttg cctgctgtat ggggttcaat atacgacggg aacggaaagc 713221 ggcattttga caagcacaac ccccatgttg atcggtattt tatccttttt cctgctgaga 713281 gaaaaaattg agaaaaagac gctgatcggc attttgctgg cggtttgcgg cgtaatggcg 713341 attaatttgt ttggagccgg gagccaagac gggacgccgc acgccttatt cgggaacatg 713401 ctgatcattg ctgcagtcat tggcgaagcg ttgtttacat tgatggccaa gctgctatcc 713461 ccgcatattt cggcactggc gatttcgacc ttcgtatcgc tcttcggctt cctgtttttt 713521 ctcccgtttg ctttgtttga ggcctcttca tttgattaca gcgtgccgac tgttttggat 713581 tggtcgtatg tgctgtatta cgcgcttttt gtcactgttt tggcgtttta cttatggtat 713641 agcggggtga cgaaggtgcc ggcgggtgta tcgggcattt tcacatccgt tcttccggtc 713701 tcagctgtca ttttgtcagg cgtgatattg aaggagccat ttgagtttgt gcatttcatc 713761 ggcattgcat gtgtcatcgg cggcatattt gttacggtca taaagaaaaa acagccggat 713821 gcgtatccgg ctgcagaaga aaagacgcta tagcctgtcc ggatcggacg ggttttttag 713881 tctttaaaca cgctcagcct ttcaaaaaga tcaccaagca tcttcacgaa catgtctttt 713941 tcctcgtcgc tgtagttttc catgacagcg gatattttgc tgaaatggcc gggcagaaat 714001 tgctccaggc gtgctttgcc ttctgttgtc agttcaatgc tgatttttcg tttatcctct 714061 gtgtgatgcc tgcggctgac aaaaccgtct ctcgccagcc cgtctagcag gcctgtaatt 714121 gttgctttcg tgacatttga ccgcttggca agctctgtcg gacttaacct atgatccttg 714181 gcatcaaaga gcagcatcag gattttgaat tttccttctg aaagccctcg gccagcaaag 714241 taatgctcca tcacatgatt catttttttt gaaatatcaa aaagagataa aaacaattca 714301 agagagccgg cgtcaatatt ggcatacgtt tcggcgtgct ctgttatatg cttatatttc 714361 ggtaaatgtt ttaattccat cgcaattagc tcccgtacat tcgttgtgac acgattataa 714421 aggagggaaa accataacgc aacttggctt ggagatgatt gacagctttt cttgggacat 714481 agtaaggtaa tatagttagg cgcctaacta atacatatag agctgaaaag gtggttattg 714541 atatgaaaca tatgttaata gcaggaggcg gaatcggcgg cttgtcagcg gccatttctc 714601 tccgtaaggc agggttttcc gtcaccttat gtgaagcggc ttcagaaaat cgaaaaacag 714661 gtgcggggat tcttcagccg caaaacgcac tggcggtgtt gaaagaactg ggcgtattcg 714721 aagattgctg taagcacggc tttcaaacag aatggtttaa aacgtttgat gaacagggga 714781 atttgctgtt tcaagtcagt gaatcctttt tagacgattc acttccggga cgcaataata 714841 tcctgcgcaa aacgttaaat gacattctca tgaagcatgc cgaggcagtg ggtgtagaca 714901 tcaagtgggg gaaaaaggtt gtcgcctatg aagaaactgc tgaatcggtc actgccttat 714961 gtgaagatgg agaaaagatg caggctgaca ttctggcggg ctttgacggc attcactccg 715021 ttgttcgtga taagatgctg caaaaggaaa cggaaaaaga gcatctcggc atgggagcgt 715081 ggcgctttta tatcgaactt cctgattaca cattcgagga cgcaacattc atgtatagaa 715141 gcggagacac acaaatcggg gtggtgccat tggcacaaca cgctggctat gtcttcgtcc 715201 tccagccttg cacgagcgat tactgggatg aggaagatac ccggtttgat agagtaaaag 715261 agattctttc tggttttcgg gggctggatt ttgtcacaaa gcacatgtca aaacagcatc 715321 ctgtcatctt taacaaactg gagcaggtcg ccgtgcagga gccatggcat aaaggccgcg 715381 tcatcatcgg aggagacgcc gcccacgccg gtgcgccaac cctggcacaa ggagcggcaa 715441 tggcgatcga ggatgccatc gtcctcgccg aagaactcca aaaccacgcc gaccacgaaa 715501 cagcattaca ggcgtactat aaaagaagag ccccacgagc gctcaaagtc cagaacctat 715561 catctgaaat cgtccgccgc aggctgaaag gagagccggg agcggaagaa ctgattgggg 715621 agtgctatgc ggtgttgagg gaagggtatt aaataggaaa agtccagaaa gtgatttctg 715681 gactttttag tcttgctctg ttttattcct tatccgctca atcacctcat gcagcccctc 715741 aggcttataa aactccaccg gtgaactgcc tttctcaaac gaaatcgtct cggcttcaat 715801 cagcgcgaca tagcgcccgt ttacttttgc gagatgaata gaatcgccaa aatccgctag 715861 caatccctta atctctgttt ctccgacttt cattttcagc tgggcctctg gcgtgtgctc 715921 gatgatttgg gcggaggctt cgatgacttg atgggtgtcg aggcgctctt ggatttcccg 715981 tttttcgctt gcttcccaaa tctcaatgtc gtgctcgaac tgcttgagtt cttcgctgtt 716041 gtcttcaaat gtctcgtaga cgtgctcttg taccatgttc atgacctgat ttttcatgat 716101 ttctggcatc gattctccgt actcgacgaa tttcagaaag tcctcaaaat agcgggcgtg 716161 cgaggcctgg tggattttca gttcaccttc ctcgaccatt ccttcctctg gcatgtacgg 716221 gtattggatg cttttcatgt tttttgtcgt gatcgccatt tcgacttttt taatgagaga 716281 agacgcgtca gagatgcggg cgaccttcgg ctcaaaatca catttcataa tgaagacaaa 716341 tgactcatca aagtattttc tcggcacggc cgaagcgacg agaaacacgc cgccgcgaac 716401 cgcgcttgtg tcaaggtacg tgcggacgaa ctgctcgctc agctcattga agtcttcttt 716461 tgtttccgcc agacgcgcgc ggttgaacat gttgtagttt gggttggaat cgagctcgtg 716521 gccgggctcg acgataaaat ggccgatttt cgtcggcacc tgctcggact gcggatggcg 716581 gtcggctttc cgtttaacga tttttttcag ttccccgtcg agaaagtcct tcagctcgct 716641 ttcttcaaat tctcccgtat caagggtctg gaagtgcttg aactgcttgt tcgcctgctc 716701 atctttgcct tccacctgta tgacataaaa ggataaaaac cgaatttcaa aatccatata 716761 taaactcacc ttattcgcgt attgtacagc ttctcaagta tagaaaaaac agcgatcatg 716821 cgtcaattgg gagaacggaa taatcatgac catgaaaggg aaatgtagtc aaatagaagg 716881 catttcatac ggaaaggaat ggttcgatga aggaaacaag cccgattcct cagccgaaga 716941 cgtttgggcc gctcggcaat ttgcctttaa ttgataaaga caaaccgacg ctttcgctga 717001 tcaaactggc ggaagaacag ggcccgattt ttcaaatcca tacacccgcg ggcacgacca 717061 ttgtagtgtc cggccatgaa ttggtgaaag aggtttgtga tgaagaacgg tttgataaaa 717121 gcattgaagg cgccttggaa aaggttcgcg cattttccgg tgacggattg tttacgagct 717181 ggacgcatga gcctaactgg agaaaagcgc acaacattct gatgccgacg ttcagccagc 717241 gggccatgaa ggactatcat gagaaaatgg tcgatatcgc tgttcagctc attcaaaaat 717301 gggcaaggct caacccgaat gaagcagtcg atgtcccggg agatatgacc cggctgacgc 717361 tcgacaccat tgggctatgc gggtttaact accgctttaa cagttactac agagaaacgc 717421 cccacccgtt tatcaacagc atggtgcggg cgcttgatga agcgatgcat caaatgcagc 717481 ggcttgatgt tcaagataag cttatggtca gaacaaagcg gcaattccgc tatgatattc 717541 aaacgatgtt ttcgttagtc gacagcatta ttgcagagcg cagggcgaat ggagaccagg 717601 atgaaaaaga tttgctcgcc cgcatgctga atgtggaaga tccggaaact ggtgaaaagc 717661 tcgacgacga aaatatccgc tttcagatca tcacgttttt gattgccggc catgaaacaa 717721 cgagcggcct gctttccttt gcgacttact ttttattgaa gcatcctgac aaactgaaaa 717781 aggcgtatga agaggtcgat cgggtgctga cggatgcagc gccgacctat aaacaagtgc 717841 tggagcttac atacatacgg atgattttaa atgaatcact gcgcttatgg ccgacagctc 717901 cggctttcag cctttatcca aaagaagaca cagtcattgg cggaaaattt ccgatcacga 717961 cgaatgacag aatttctgtg ctgattccgc agcttcatcg tgatcgagac gcttggggaa 718021 aggacgcaga agaattccgg ccggaacggt ttgagcatca ggaccaagtg cctcatcatg 718081 cgtacaaacc attcggaaat ggacaacggg cctgtatcgg catgcagttt gcccttcatg 718141 aagccacact tgtgttaggc atgattctaa aatatttcac attgattgat catgagaatt 718201 atgagcttga tatcaaacaa accttaacac ttaagccggg cgattttcac atcagtgttc 718261 aaagccgtca tcaggaagcc attcatgcag acgtccaggc agctgaaaaa gccgcgcctg 718321 atgagcaaaa ggagaaaacg gaagcaaagg gtgcatcggt catcggtctt aacaaccgcc 718381 cgcttctcgt gctgtacggc tcagataccg gcaccgcaga aggcgtcgcc cgggagcttg 718441 ctgatactgc cagtcttcac ggcgtaagga caaagacagc acctctgaac gaccggattg 718501 gaaagctgcc gaaagaggga gcggttgtca ttgtgacctc gtcttataat ggaaagccgc 718561 caagcaatgc cggacaattc gtgcagtggc ttcaagaaat caaaccgggt gagcttgagg 718621 gcgtccatta cgcggtattt ggctgcggcg accacaactg ggcgagcacg tatcaatacg 718681 tgccgagatt cattgatgag cagcttgcgg agaaaggcgc gactcggttt tctgcgcgcg 718741 gggaagggga tgtgagcggt gattttgaag ggcagcttga cgagtggaaa aaaagcatgt 718801 gggcggatgc catcaaagca ttcggacttg agcttaatga aaacgctgat aaggaacgaa 718861 gcacgctgag ccttcagttt gtcagagggc tgggcgagtc tccgctcgct agatcgtacg 718921 aagcctctca cgcatccatt gccgaaaatc gtgaactcca gtccgcagac agcgatcgaa 718981 gcactcgcca tatcgaaatt gcattgccgc cggatgttga atatcaagag ggcgaccatc 719041 ttggcgtatt gccaaaaaac agccaaacca atgtcagccg gattcttcac agattcggtc 719101 tgaagggaac cgaccaagtg acattgtcgg caagcggccg cagtgcgggg catctgccat 719161 tgggccgtcc tgtcagcctg catgatcttc tcagctacag cgtcgaggtg caggaagcag 719221 ccacaagagc gcaaatacgt gaactggcgt catttacagt gtgtccgccg cataggcgcg 719281 aattagaaga actgtcagca gagggtgttt atcaggagca aatattgaaa aaacgaattt 719341 ccatgctgga tctgcttgaa aagtatgaag cgtgtgacat gccgtttgaa cgatttttag 719401 agcttttacg gccgttaaaa ccgagatact attcgatttc aagctctcca agagtgaatc 719461 cgcggcaagc atcgatcaca gtcggtgtcg tgcgcggccc ggcgtggagc ggccgtggcg 719521 aatacagggg tgtggcatca aatgatttag ctgagcgtca agccggtgat gatgtcgtga 719581 tgtttatccg cacaccggaa tcccggtttc agcttccgaa agaccctgaa acgccaatta 719641 ttatggtcgg gccaggcacg ggagtcgcgc catttcgcgg tttccttcaa gcccgcgatg 719701 ttttaaagcg ggagggcaaa acgctcggtg aggctcatct ctattttgga tgcaggaacg 719761 atcgggattt tatttaccga gatgagcttg agcggtttga aaaagacgga atcgtcactg 719821 tccacacagc cttttcccga aaagagggca tgccgaaaac atatgtccag catctcatgg 719881 ctgaccaagc agatacatta atatcaatcc ttgaccgcgg tggcaggctt tatgtatgcg 719941 gtgatggcag caaaatggcc ccggatgtgg aggcggcact tcaaaaagcg tatcaggctg 720001 tccatggaac cggggaacaa gaagcgcaaa actggctgag acatctgcag gataccggta 720061 tgtacgctaa ggatgtctgg gcagggatat agataaagaa gactggagac atccagtctt 720121 tttagtcctt tcgaaaaaat ggtgatcgcg ctaaacattg atgcatacaa taacttcagt 720181 ccgccggaag ggcgggctgt ctgcaaaacc tatttttcgt ttttgctagt ttatgttatt 720241 cttatactcg gtatctattt cttttttcaa aggcacacat gacaaaagaa atcctttttt 720301 tatttccgag aaaaaaatgt gaaacgaaat gaaggtttct ttcgtccagt gattggtttc 720361 caaatggttg taataaaaat gatatggtgc gaaacataaa tattccggct tgccgcggtg 720421 tatttattgt tgtgtgatgc cttgattttg tttggaaaga aggaattgga aggcaggata 720481 taaagagcag gtaaatatga atgaagaact taaagtgttt aagaaagtag aggttgccat 720541 gaagaaactt ttttcttaca aacttagctt ttttgtgctg gctgttatac tgttttgggc 720601 aaaaacgtat ttatcctaca agactgagtt taatcttggg gtaaaaggca caactcagga 720661 gatcctcctg atatttaacc cattctcaag cgccgtcttc tttttaggac tggctttgct 720721 ggcgaaaggg cgtaaatcag ccattattat gctgattatc gatttcttga tgacatttgt 720781 gttatatgca aatattttat tctatcgttt ctttgacgat ttcttgacgt tcccgaacat 720841 taaacagtcc ggaaacgttg gaaacatggg agacgggatt ttcagtatca tggccggtca 720901 tgatattttc tatttcttag atattatcat tttgattgcg gtattgatct ggagacctga 720961 attaaaagaa tacaaaatga aaaaacgctt tgcatcttta gtgatccttt ctgggatcgc 721021 actgtttttc atcaacctgc actatgcgga aaaagaccgt ccgcaactgc tgacaagaac 721081 gtttgaccgc aattatattg tgaaatattt aggtttatac aactacacca tttatgacgg 721141 tgtacagacg gctcaaacag agacgcaaag agcctatgca agcagcgatg atttaacaag 721201 tgtcgagaat tacacgacgt ctcattatgc gaaaccaaac gccgagtact tcggctctgc 721261 caaaggcaaa aatatcatta aaattcacct cgaaagcttc cagtcattcc tgattgacta 721321 caagctaaac ggtgaagagg tgacgccttt cttaaataaa cttgcgcacg gcggggaaga 721381 tgtgacgtat tttgataact tcttccatca gacaggccag ggaaaaacat ctgatgccga 721441 gctgacaatg gataactcga tcttcggtct tcctgaaggc tccgcgtttg tgacgaaagg 721501 cgaaaacacc taccagtcgc ttcctgcgat tttagaccag aaggaaggct atacaagcgc 721561 cgtcctgcat ggtgattaca aatcgttctg gaaccgtgac cagatttaca aacatatcgg 721621 atatgacaag ttcttcgacg caagcacgta tgatatgtca gatgaaaatg tgattaatat 721681 ggggcttaag gataagccgt tctttacaga atcgattcca aagcttgaat ctcttaaaca 721741 gccattttat gcgcatttga ttacattgac aaaccattat ccgtttaacc ttgatgaaaa 721801 agacgcgtct cttaaaaaag cgacaacagg cgataacaca gttgacagct acttccagac 721861 agcgcgttac cttgacgaag cgcttgagca attcttcaag gagctgaagg aagccggcct 721921 gtatgacaac tcagtcatca tgatttacgg tgaccataac ggtatttctg aaaaccataa 721981 ccgagcgatg aaagagattc ttggaaaaga gatcacagat tatcaaaacg cacagaacca 722041 gcgtgtgccg ctgatgatcc gcgttcctgg caaaaaaggc ggagtgaacc atacgtatgg 722101 cggcgaaatt gacgtcatgc cgacacttct gcacttagaa ggaattgatt ctcagaaata 722161 tatcaacttt ggtactgatt tattctctaa agaccacgac gatacggtgg cattcagaaa 722221 cggagacttc gtaacgccga agtacacatc agtcgacaat atcatttacg atacgaagac 722281 aggtgaaaaa ctgaaagcga atgaagaaac gaagaatctg aaaacaagag tgaaccagca 722341 gctgagcctt tcagacagtg tcctgtacaa agacttgctg aggttccata aactaaatga 722401 tttcaaagcc gttgatccgt cagactatca ttacggcaag gagaaagaaa tcaaataaga 722461 tgaaaaagag ccttgagcgg gcgcattgcc ttcgctcaag gctctttttt tggttataca 722521 accaacttga aaaaatagat tccatttggt caccaaggct ggctttctct catatcatta 722581 cagtagattt tgaaaccgga ttgaaatcgg acaaattatc ggggaaatgc cttgatagat 722641 tgtgaagatg taccaggttt cgaactcaat attcatagag atgaggggta gagatgaaag 722701 cggtcattct ctgcggcgga aaaggaacga gaatgagtga agtcacgaat gacattccta 722761 aaccgctcgc catgataggc ggcaaaccga ttctatggca tattatgaaa atttatcagt 722821 actacggagt aaacgagttt attctgcttt tgggctataa aggagaaaaa atcaaggaat 722881 actttctcga ctatgaatgg aagcacaaca gcctgacact cgacagctct acgggagagg 722941 tacagatgct ggggcagcct gaaacgtgga aaattacgtt tttggagact ggggtagata 723001 cgctgacagc cggaagaatc ttgcaggcga aagactatat cggtgatgaa acatttctgc 723061 tcacctatgg agacgggctg gccaatatca atcttttcca tctcatcagc tatcatcaga 723121 caaaaggtgc tgccgcgact gtcaccggca ttgacaaagt ctcgcagttt ggcaccttga 723181 cagttgagga tggcatggcg aaaacatttt ctgagaagac atcaagtgat ggaatcatca 723241 acggcggatt cttcgttctt agtccaaagg ttttcgatta tttgccgaag gacgggaaca 723301 cgatgttcga agatgaaccg ctgaagaacc ttgccaaaga tggggagctt gctgtgtacc 723361 gccattacgg attttggacg gccatcgata cgtataaaaa tctcttagaa gtcaacaaaa 723421 tgtggaatca aggacaacaa gtatggaagg tatggtgaat tgatttgagt ttctggaaaa 723481 ataaaaacgt atttgtcacg ggatgcacag gtcttttagg aagctatttg gtgaaagagc 723541 tgatcgaaca gggcgcaaac gttacggggc tagtcaggga tcatgtgcct caatccaatc 723601 tttatcaggg agaacatatc aagaaaatga acatcgtgcg gggctctctt gaggacttgg 723661 ctgtgattga acgcgcgctt ggcgagtatg agatcgacac agtctttcat cttgctgcac 723721 aagcgattgt cggcgtggca aaccgcaacc cgatttctac ctttgaagcg aatatcctcg 723781 gcacctggaa tattctcgaa gcctgccgca agcatccgtt aattaagcgg gtcattgtcg 723841 cttcaagtga taaagcttac ggcgatcaag aaaaccttcc atacgatgaa aacatgccgc 723901 tgcaaggcaa gcacccgtac gacgtctcaa aaagctgcgc agatctgatc agccacacct 723961 attttcacac gtacgggctt ccggtctgca ttacgcgctg cggaaactta tacggcggcg 724021 gagatttgaa cttcaaccgc atcattcctc agacgattca gcttgtgctg aacggggaag 724081 cgccggaaat ccgaagcgac ggcacatttg tacgggacta cttctatatt gaagacgccg 724141 ttcaggctta tctgcttctt gcagaaaaaa tggaagaaaa caatcttgcc ggagaggcct 724201 ttaacttcag caatgagatc cagctgaccg tacttgaact ggtagagaaa atattaaaga 724261 aaatgaacag taatctgaaa cctaaggtgc tgaatcaggg aagcaatgaa atcaaacatc 724321 aatatttatc cgcggaaaaa gcaagaaagc tgctgaattg gacaccggcc tacactattg 724381 atgagggact tgaaaaaacg attgagtggt atacggaatt cttcaaaaag taatgtgaaa 724441 cgaggtgaac aagactgtga ccagcgcgta ttgcaccgtt ttatcaaaag gaagattata 724501 tcaggcagtc gctttgttta agtcgttaga gcaagttgat caagacagtc ccatttttat 724561 actttgcatg gatgaagata cgcaccgcgt gttacagaag ctgaagatga agcagctgaa 724621 ccttgtgccg gtggccgctc ttgaaaatga attgctgctg aagctgaagg aaactagaga 724681 tcaaagtgag tattgctgga cgatgaagcc gatctttctg caagctgtgc tgaacagcaa 724741 tcctgagctg gagcgtgtga cgtatattga cggggatctc tttttctatg cagatccatc 724801 gccgattttt gaaaaccagc cggactgctc ggtgttgctt tcacgagggg atattgtaat 724861 cccttctttt gagaaagagc agattgacat gctgcagcgt cttttaggca gatataattc 724921 cgggtttatc agcttcaagc atgatgatgc aggcacggat tgcttggagt ggtggaagga 724981 acgctgtctt gaggaatgca aaaatgcacc gggtgaaggg aaattcggtg atcagggcta 725041 tttggattat atgtctgagc tgtttccgaa tgtgtgtgac attacaacac ccggcgtgaa 725101 catcggccat tggaattatg gacagcatac gttttcctgg aaagatggcc ggatcgtgct 725161 ggaggatggc agtccgctga tcttttatca tttcagcgga taccgaatcg tcagcatcaa 725221 tgaaatcaaa cagattcatg aaacaacccg cacagatctg ccgtttgtgc atgaactgta 725281 tcaagagaca ctgccgcata tcattcagca catgcaaacg ttagaccctg aatttaacgg 725341 ttttgcttca aaagatgaca acaaataaat gagtaaatac aggaagtgaa aatgaagtga 725401 aagcaagcgt tattattcct gcatataatt cgaaggagcg tctttacaac agccttctgt 725461 cattaaacca gcaggagtgc gatgaagaat ttgaagtcat tgtagcggac aatggctctg 725521 aggacgggac gctctcgatg cttgagtcat ttcaagctga ttttccgctg atctttacac 725581 ggattaaaga aaacaggggc attgcgtacg gacgaaatca ggcgcttcgc aatgccagag 725641 gagacatcct gattttccat gacagcgata tgcttgcggc aaaggacctt gtggcaaaac 725701 atattaaagc ccatgagaac gaagagaatc tcgtcgtgtg cgggttgttt tggaaacgga 725761 tctacagttt ttactatgaa cgatttgaag aagaacataa ggaacagctc gcaaagctca 725821 caggtgaaat gccgaagaaa gacaaacaaa agctgctgga ggaagcggac atcaaaaacg 725881 gaagctttct tgataaaagc tttgacctcg ataccgactt tatagacgtg ctcaagaaga 725941 ttttagatga gtacggcgat gacttgaaag gctatcatat gccatggcgc ttttttatca 726001 cgaataattc ctctgtgaaa cgcaagcatg tggttgacct cggtttattt gacgaaggca 726061 ttgtgcggta cgggtttgag gattatgacc tcgggatcag gcttcatcag gccggattga 726121 ccttcaggct tcgccgtgat attgtcagtg ttcatcagga acatccaagc aattgtaagt 726181 ctgtagacga tattcgggca aacattgcct atatgtgcga taaatacaat aacatccgct 726241 ccttagacgt tcatctcgct tttaatgggc cgttcccgcc tgacatgacg aacagaatca 726301 tggctgatat tcaaaagctg ctggaatcac agaaatatga tatgctgctg aatctgtttc 726361 ttgagcttct gcatgttgtt aaagagcgca acattgatcc ggattggcga aagaaatccc 726421 caagggtgac ggcgaaaagc tttgatttgc aaactgtccg caagcttctg cctaaggcga 726481 agaaaaagct aggcgtgaac gattttgcca acgcactgta tgcgcttgtc aacgatttgc 726541 tgcacgtgga tcttagatca ttggatgtgg tataagtgag tacatttcat ttttcaacga 726601 tagtgtcaag gacacatatc tttaagctca tgcctatgat tcattctctc catgagcatt 726661 gcgatgattt tcatttatat gtgctgtgtg tcgaccagaa agcgtatgaa ttgcttcagc 726721 acgttccatg ggagcatgta acctttgtgc agctgcatga aatggaagac ccggagctgt 726781 tgaaagcgaa aagcaacaga acgtttcatg aatattgctg gacgttaaag cccgcctttt 726841 tgtttcatgt gatgagcaag tgggatgacg ctgaatactt tgcccatatg gatacggatc 726901 tatttttctt ttctgatccg gcacgtattt ttgcagaaaa cccaacggcg tctctgtatt 726961 tgactgatca tcgtaattcg ccgcgcttca tgtcctacta cgaccgaacc ggacgcttta 727021 atacaggctt tgtcggcgcc ggtaatacaa aggaagcata tgaagcggtg tggcagtgga 727081 gacaggactg tattgaattt tgcacggtcg aaatggatac ggaacgaaag acatatggtg 727141 atcaaagata tgtggagaaa tggccggagc agtttaaagg tgttcatgtt gtcaaatcca 727201 taggagccaa tacagcgctt tggaatatcg aaaactataa ggtcgggcaa aaggacggcc 727261 gcgtgtatat agatgaaacg ccgctgattt tctatcattt ctctgggttt acgctggtga 727321 cagaaaaaga gtttaatctt tgctggtact accggattga agacgaagcg acaattaaga 727381 tgatttatat gccctatata ttaaatctga aaagatggat tgatgaaata cagtcggcgt 727441 ttccggactt tgcggatggc tttatcccga agcacgcagt gcctgacact cattttatcc 727501 agctggatta aaaaaccccc tgccgcctgg caggggtttt ttcagctatg ccattctctc 727561 agcttctggt cacttggcaa taggaaggca aggatgccga ggacagggag aaaggcaatg 727621 gcgatcatcg tcggggtcag tcccgcggca tcaatcagag cgcccagcgc cacagcgccg 727681 attgcgccca tcccgaaggc aagcccgacg gttaaaccgg acattgtgcc gatttttcca 727741 ggaactagct cctgtgcgta gacgaccgtt acagaaaagc tcgacatcag aaccaagcca 727801 atcaatgcga gcacgccgta ggcgagaacc gggccggcaa atggcagcac aatcgccagc 727861 ggcgccgagc ataacagcga accgaggata acgaagcgtt ttccaaaacg gtctgcaagc 727921 gggccgccga gaaacgtgcc gatcgcgccg aacagcaaga agacaaaaat atagctttgt 727981 gcctgctgaa tgcttacgtg ataggtatcc atcgcgtaaa acgtgtaaaa gttaccgatc 728041 gcactcgtat accaagaacg agcaaaaatg agaaatataa taataataag agcagataca 728101 acagatttgg tgatggccgt gttttcagcc gttttctttt gcttgcctga tttctgggca 728161 aggctgccga gacgtgaggc gtaccatttc gcaatataca tgagaaacat aacagcaagc 728221 gcggcgacaa gcgtgaacca aacagcgccg aattgcccga gcggcacaag gatcagcgcg 728281 gtgatcagcg gtgccatcgc ctggcctgag tttccgccca cctgataaat cgattgggcg 728341 agcccgcgtt ttgtgccggc ggccatatac gccacacggg agccctccgg atggaaaatg 728401 gccgagccta atccaatgaa aaacacacag cataagatcg ttatgaatga cggggcaaat 728461 gcaaggccca aaatgccaag catgctggcg gtcaaaccga ctggcagcgc atacggccgc 728521 ggccgtttat cggtatacca gccgacaaca ggctgcatga cggatgacac catgtttaat 728581 gtgaaagcaa tgatgccgag ctgtgtaaac gtcaggctca tggagcgttc caaaataggg 728641 aacatggccg gaatcacagc ctgaagcgaa tcgttgagca tatggcaaat tccgataata 728701 atcaaaatcg gatacaccgt ggtgcctggt ttttgaactg ttttttcttt taacggggcg 728761 gcgatagcca ttgagtctcc tccttacata tataaccaaa gcataccacc atattattca 728821 taaggtgaag aatttatcaa gaggaaaaaa gattcttatg aaagaaatac cgtcagcctg 728881 attagcagct gacggtattt tcgatattca aaatgtgata tagctcttca agcttacgaa 728941 tctcataggt tggtatgatc tctggcacat tcggcttcat gtcagggttc atccagcaag 729001 tatcaagccc ggcgagctgt ccgcctttga tatcagcagt tagtgaatcc ccgatgatta 729061 atgtgtgctc tgctgaaaat tgaggaatcc gttcaaacac gtaattgaaa tattccttca 729121 tcggcttttg gaagccggtg tcttcagaaa cgaaaatgtc cttgaagaat ggaaataatc 729181 ctgaatcacg gagacgctta tattgtgtgt gagacacgcc gtttgtcacg atgtacaaat 729241 caaactgttg ctgcagattt gagatgagat caaatgcacc gtcaataagc tgatgtcctt 729301 cttcaagaaa gcggcggtat ttttgctcaa gcaaagcgcc gtccgcttcg taaccgtact 729361 ccttgagcaa agcggaaaaa cgtgtgttta cgacttcatc ccgtgtcatc ttaccttctt 729421 caaaggctct ccagagacct tgattgatgg ttttatactg cgccttcatg tcatttgtta 729481 aaggaatgtt ctgatcttca aacagcaaac gcagggctaa agcttctgcc gcttgaaaat 729541 caaggatggt atcatctaca tcaaataata aagtgcggta tcgcttcatc tgtgtgtctc 729601 cctttctcat atgtattcaa agtatagcac ataaaaaaag gaaaaagccg gcgggtgagg 729661 caccgccggc tgaaaagaga ttatttgttt aataagctgt gttttctcga atataggaag 729721 taaaccagcg ttccgacagc gatccagatg acaaatgaaa gccatgtgac gccgggaagg 729781 ctgtacatga accaaaggca gatgcctgcg ctgataatcg gcacaaccgg aacgaatggc 729841 actctgaagg acgctttgat ttcaggatgt ttctttctta acacaatgac agcaatggaa 729901 atgaccgtaa acgcggcaag tgttcccatg ttcaccagat gggccagcgt tccgaggtta 729961 ataaagccgg cgattcccgc tgcaacgatc cctgtcagcc atgtgttgcg gaacggggtt 730021 ttaaatgacg gatgaacctt tgcgaacaat ccaggcagaa ggccgtctct gctcatggca 730081 aatgtcaagc ggacctgtgc gtacagcaaa gcgagcatca ccgtcgtaat cccgataatc 730141 gcaccgacag aaataattcc ggcaacagcg tcctgtccga cgaatttcag cgcaaaggat 730201 acaggatctc cgacattcaa tttggcataa ggcatcatgc ctgtcagcac aagcgatacc 730261 gcgatgtaca gaaccgtaca gacggctaga gctgaaataa tgccgacggg catgtttttt 730321 tgcggatttt tcacttcctc tgatgcgtta gaaaccgcgt caaacccaag gtacgcgaag 730381 aatacagtgg cagcgctaag tatgacgcct ttcatcccga atggcataaa aggagaccag 730441 ttatccggtt tcacatagcc gatgccgaca ataatgaaca ataatatgat cgcgattttc 730501 atcagtacga tgacgttgtt aaagcgtgtg ctttccttga cgcctctgct gacaatcgca 730561 gtgatgagga gaatgatcac cgcagccgga aggttaaata cggcgcccgc catgcttccc 730621 ggcgctcctg tcagtgcagc cggaatatga agattgaagc cggcaagcag tgattgaaag 730681 tatgaagacc agccggtggc aaccgccgac agtgcaatga catattcaag catgagatcc 730741 catccgatca aaaaggcgag cagctctcca agtgtcacgt atgagtatga gtacacgctt 730801 cccgaaatcg gaatggaaga cgaaaactca gcataacaga aagcagccag cgcacaggcg 730861 agccccgcta aaataaacga tatgatgagg gcgggacctg caccggtcgc tgccactgtt 730921 cctgtaatga caaaaatccc tgtaccgatg acacaaccga taccgagcaa ggttaaatca 730981 aatgcgctta acgtacgggc aaggcttttt gacttgctct gcgcactcaa tgtttcaagc 731041 ggtttttttc taaataatga actcatcaaa agttcctcct agaaatattc aaaatattct 731101 aatcattata tgcagttctt gttgtattat attgtcgaaa tttgacgtag tcaataaaat 731161 atttttctgc tttaaatgat agaagcgaaa cagcgttgtc gtatcatagg atagtaattt 731221 ttactaatcg tatattcaat tttatgcaag atgaaccgat agaaaaaata gattcgccca 731281 tattttgatt tgcggttata aaggagatgc tgaccatgtt tcaatatgaa gagttgaata 731341 aacagtttat cggcgggaaa tggcaggagg gcagcagccc aaatgtattg gaaaacaaaa 731401 atccttatac tcaaaaaaca ttcacaacat tccgtaaagc gactgctgac gatgtagatg 731461 aagcgtatcg ggcagcggcg ctggcaaaga aaaaatggga tgcggtcaac ccgttcgaga 731521 aaagaaccat tttagaaaaa gccgtcacgt atattgaaga aaatgaagaa gccattattt 731581 atttgattat ggaggagcta ggcggtacaa ggctcaaagc agcttttgaa atcggtcttg 731641 tcaaaaacat cataaaagaa gcggcaacgt tcccaatccg catggagggg aaaattcttc 731701 cgtcaacaat agatggcaag gaaaacagat tatatcgcgt gccggcaggc gttgtcggtg 731761 tcatcagtcc gtttaacttc ccattctttt tatctatgaa atcagtggcg cctgcactcg 731821 gagccggcaa tggcgttgtg ctaaagccgc atgaggaaac gccgatttgc ggcggaacgc 731881 tgattgcgaa aatttttgag aacgcgggaa ttccagcggg gctgctgaat gttgttgtca 731941 cagacattgc tgaaatcggc gacagcttcg ttgagcatcc agtgccgcgg atcatctcat 732001 ttaccggttc tacgaaagtc ggcagctaca tcggacagct tgcgatgaag cattttaaaa 732061 agccgcttct tgagcttggc gggaacagcg ccttcatcgt acttgaggat gcagatatag 732121 aatatgcggt caatgcggcg gtgttcagcc gatttacaca tcaagggcag atttgcatgt 732181 cagccaaccg cgtgcttgtt cattcttcta tttatgacaa gttccttgag ctgtaccagg 732241 caaaagtgga atcgctgaaa gtcggcgacc caatggaccc tgatacgatt atcgggccat 732301 taatcaacag cagacagacg gacgggctga tgaagactgt agagcaagca attgaagaag 732361 gcgctgtacc agtgaagctt ggcggattta acgggacgat cgtggaaccg acgatcttaa 732421 aagacgtcaa accgttcatg agcattgcca aggaagagct gttcggacca gtcgtctcct 732481 ttatgaagtt tgattcagaa gacgaagcgg tggatatcgc aaacgaaacc ccgtttggct 732541 tgagcggtgc cgtacatacg tcaaatcttg agcgcggcgt ggcttttgcg aaacgcattg 732601 aaacaggcat gattcacgtc aatgacacga ccatcaatga tgaaccgaat gtagccttcg 732661 gcggtgaaaa gcaatcaggc ctcggccgtt taaacggtga gtggagcctc gaagaattta 732721 caacgctgaa atggatctcg gtccagcacg aaaaacgcag cttcccttat taatgaaaag 732781 gagtgaatgg aattgaccat aaatacggaa aaagaaaccg cagatattct ggacgcattt 732841 atcaaagtag ccccttattt aaacagcctg gttcaggatg atattacaat cggcatttat 732901 gatacggaaa aactgctcgt gaatataccg gccaaaacct tttcgctgaa cgtaaaagcc 732961 ggcgatccgc tgcaggaagg ggatatcatc acagatgcca tccgcagcaa tcagaagaag 733021 acgagcatgg ttccgaaaga attgttcggc ttcccattga tcgcgcgtgc catcccgctg 733081 cacgacgaga atggaagagt cattggaggc gtcggcctcg gaacgagcct tgaggagtcg 733141 tcaaagctgc atgatgtcgc ggaaagctta tcagctgttg ttgaacaaac agccgcggct 733201 atttccgaca tttctgaatc aattaacggg ttttcaactc aaatgtcggg catttcctct 733261 caggcgaaaa aagtaagcga aagcgccggt gaaatcgccg atatttcagt aactgttaaa 733321 ggcatctcgg accaaagcaa tctgctcggc ttgaacgccg cgatcgaagc ggcaagagca 733381 ggggagtccg gaaaaggatt ctctgtcgtc gcagatgaga tcagaaagct agcgacgcat 733441 tcaaaagaaa atgtcggcca aattgaccag attacgaaaa aaatccacag cctgctgaaa 733501 gggctggagg aatccattga gtcgattaac cagcatacag acggacaagc cgctgctgtt 733561 gaacaaattt ccgccacgat gcaggagatt tcaggaagcg cgcagcatct tgcgaaaatg 733621 gccgaaaaag cgcttgagga agagtaagag accggggaca aacatccccg gtctttttct 733681 tatcctgcat ttccatgaaa ttcgtctgac gttttactag ttttattcca gcggctgatt 733741 taaaatgtac acatgaactt acgtgaggat tgataggaac catgagcata ttaaaagcgg 733801 aaaatcttta taaaacatac ggagataaaa cattatttga ccatatctcc tttcatattg 733861 aagagaatga gagaatcgga ttaatcgggc cgaacggaac aggaaaatca acgctgttga 733921 aagtgattgc cggcttggaa tctatcgaag aaggagaaat cacgaaatcc ggaagcgtgc 733981 aggtcgaatt tcttcatcaa gacccggagc tgcctgcggg gcaaacagtg ctggagcata 734041 tctattccgg tgaatcggct gtgatgaaaa ccttgcgtga atatgaaaaa gcgctgtatg 734101 aactggggaa agatcccgaa aatgaacagc gccagaaaca cctgctggca gcacaagcga 734161 aaatggacgc gaacaatgca tgggatgcaa acaccttggc aaaaaccgta ttgtctaagc 734221 tgggcgtcaa cgacgtaaca aaaccggtca atgagctctc aggcggccag aaaaaacggg 734281 tggccattgc caaaaactta attcagcccg ctgatttgct cattttggac gagccgacaa 734341 accatttgga taatgaaacg attgagtggc ttgaagggta tttaagccaa tatcccggcg 734401 ccgtcatgct ggtgacgcac gatagatatt tcttaaaccg tgtcaccaac cgcatttatg 734461 agcttgaaag aggcagcctc tacacttaca aaggcaacta tgaagtgttt ttagaaaaac 734521 gcgcggaacg ggaagcgcag gctgagcaaa aggaaacgaa gcggcaaaac ctgctgcgcc 734581 gcgaactggc ttggctcaga cgaggagcga aagcccgctc cacaaaacaa aaagcgagaa 734641 ttgaccgggt agagacgctt aaagagcaga caggccctca gtcatcaggt tcactcgatt 734701 ttgccattgg ctcgcaccgt ctcggaaaac aggttattga agcggagaac gtcatgatcg 734761 cttatgacgg ccgcatgctc gtcgaccgtt ttaatgaact tgtcatacca ggtgaacgga 734821 tcgggatcat cgggccgaac ggcatcggga aaacaacgct gttaaatgcc cttgccggcc 734881 gtcatacgcc ggacggaggc gatattacga tcggacagac ggtcagaatc ggctactata 734941 ctcaggatca tagtgaaatg aacggtgagt taaaagtcat tgactatata aaagaaacgg 735001 cggaggtcgt aaaaacggca gatggcgata tgattacagc tgaacaaatg ctcgagcgtt 735061 tcctcttccc gcgttcgatg cagcagacgt atatccgcaa gctgtccggc ggggaaaaac 735121 gccgtttata cttgcttcag gttctcatgc aggagccgaa tgtcctgttt ctcgatgagc 735181 cgacgaacga tttggatact gaaacattaa gcgttcttga ggattatatt gaccagttcc 735241 caggcgtcgt catcaccgta tcccatgacc gctatttcct tgaccgcgtc gtcgaccgtt 735301 tgattgtatt tgaaggaaat ggtgtcattt cccgctttca aggctcctat agcgactata 735361 tggaggagtc aaaagcgaaa aaagcggccc caaaaccggc agctgaggaa aaaacggctg 735421 aagccgagcc gaagaaaaaa cggaaaaagc tttcttacaa agaccagttg gaatgggacg 735481 gcatcgaaga taaaattgcc cagctggaag aaaagcatga acagcttgaa gctgacatcg 735541 ccgcagcagg cagtgatttt ggcaaaatcc aagagctgat ggccgagcag gcgaaaacgg 735601 cggaagagct tgaggctgcg atggaccgct ggacagaatt gtccctcatg atcgaagaac 735661 tggaaagcta aaaagcgtgg ccgcagcagg ccgcgctttt tttcacataa tggacaaaaa 735721 cgaaccggcc tgcttatgtt aggataaagt tgtgtgtcag cggcacatgg aaaactaacg 735781 gagatgatga agtatgacat gggcgatcgt gatgttaatt ctcatgagtc tggtgaaaat 735841 cgtattaacc tgtcttccta caggcgtcat agaatggctg ctcggcaaat ttgaagtgca 735901 cgccaagctg agtgacgaaa atgcgagtct ctctctagat ggaaaacgcc tcgagggtgc 735961 agagaagcag aaagtgattg atcaatttaa cgaagctatc ttcctggaaa aatattatat 736021 ctatccaggt gatgaagagc gttatttaca tccggaaaac ggcggcacgc ctctggtgat 736081 agatacaaaa aaaggaaaaa aagacgtgaa gctgttcgtg taccgctacg acgaccatat 736141 cgacgtcgtg aaacagtaca agaagaaagt gatcgcgtat cgagtgcttt ctgaaagcct 736201 tcaaaaagag tctctgtcag tggcgggaag tttagcttaa acaggaaagt gaaagacggg 736261 tgctgtatgc tgctcgtctt ttttattgtt ttttaaaact taacgtttac gttaaggttc 736321 aaaaggtgta taatggtaac agaaacggcg aagggggatt taccttggaa tggatgaaga 736381 ttgatcaagt ggccaaaaga agcgggctga caaagcggac catccggttt tatgaagaaa 736441 tcggcttgat tccggcgccg aaacggacag acggcggtgt aaggctttat tcagaggatg 736501 atatggagga gcttgagaaa gtcatcagca caaaagaggt gctcggtttt tcccttcagg 736561 agcttcagca tttcatggaa accagccgcc agctagagtt aaacaaagag gggtatttgt 736621 tgtcactgga tcctaaggaa cggaaagaaa aactggagga aattcaggaa accctgaatc 736681 accagctgga tttgattgat gagaaaatcc gcacattcca aagctttaaa gaacgcctgc 736741 agggcatgaa aggcaaagcg gaacgcgcca ttcaatcaat cgaatgaaaa gtttgttaaa 736801 cgctattttt gtagcgtttc ttttaatgga ataaagatgg aggttaggtc aaatggataa 736861 gacaacacaa gtgaatcaga aaacgggttt gctcagccag ccaaaagcgg tatgggctgt 736921 cgcgtttgcc tgtgtgattt cttttatggg aatcgggctg gtcgatccaa ttcttccggc 736981 cattgccgca caattgcatg cttcacctag tgaagtatca ctcttgttta caagttattt 737041 gcttgtaacc ggatttatga tgtttttctc aggagccatt tccagccgca tcggcgcgaa 737101 atggacatta attctcggac ttatttttat tattgtgttt gcggggcttg gcggcagctc 737161 aagctcaatc gctcagttag tcggctatcg cggcggctgg ggattaggga atgctttgtt 737221 tatttcaaca gcgcttgcgg tcatcgttgg cgtgtcagtc ggcggcagcg cccaagcgat 737281 tattttgtat gaggccgcgc tcggtctcgg gatttctgtc gggccgcttg caggcggaga 737341 gctcggaagc atttcatggc gcgcaccgtt ttttggagta tctgtcctga tgtttattgc 737401 gttaatcgcg atttctttca tgcttccgaa gctgccgaaa ccggcgaaac gcgtcggtgt 737461 gtttgatgcg atgaaggcac tcaaatataa aggcctgctg acaatggcgg tatcggcatt 737521 cctatacaac tttggatttt ttattttgct agcttattct ccgttcgtac tggatttaga 737581 tgaacacggt cttggatatg tcttcttcgg ctggggcctt ctgctggcga ttacgtcagt 737641 ctttacggcg ccgctcgtgc acaaagcgct gggcacagtg cgttcgctag tcgttctctt 737701 tatcgccttt gcggccattc tcgttattat ggggatctgg acagaccatc agactttgat 737761 tattacatgt atcgttgtcg ctggtgctgt cctcggtatg gtgaatacga tcatgacaac 737821 cgctgtgatg ggttctgcgc cggttgaacg ttcaatcgcg tcttcagcct acagctcagt 737881 ccgcttcatc ggcggcgcgc tcgccccgtg gattgcagga atgctgtcag aacactttac 737941 tgcaagcaca ccatatacag taggcggaat cgtcgttttt gtcggcatgc ttgtccttct 738001 catgggacgt aaacatcttg ctggaattaa ggcggggcat taataacgaa agacactgcg 738061 catatgcagt gtctttttat tcgttataat gcatcataat cgaattggtg caggaaagga 738121 caacctttat gacacaattt tactattttc cggctgaaaa ctccctttag aaaccggttt 738181 tttcggtcag caagaacggc gttcgcggaa agggcatccg cttcggtcag gcattgatgc 738241 ggctgggatt tatcttgcag aagctgagaa tgtgtccgtt catttacgat tgccatttca 738301 gtgatggttc atgctgtaga ggggacgttt gccatggata aggcaaaacc tgacgaatat 738361 gatcagaaat gtttagaaac gctctatcaa tacatacaca gcgtcatgaa aaacagcttt 738421 tctcggtcga gtggtttacc gcttgggaag atgaggagga ttttgagctg tctgccaaaa 738481 gagagctgac acttgatgaa ttcacatctc cattgcagct cattttaaaa gacagagagc 738541 ttttgagaat cgttcagaaa aaatggcagt aaaaaacccg ccctttagca ggcgggtttt 738601 tttataaatt aaagcacttt cgtcgtccaa gactcgcagt tccacgtttc tgtcgcaata 738661 tccatataaa agtctggctc gtgggaaatg agcagaatgg agcctttata ttctttcagg 738721 gcgcgcttga gctcttcctt ggcatcggca tccaagtggt ttgtcggctc atcgagcacc 738781 agcaggtttg tttctgagtt gattagcttg cacaatctga ctttcgcttt ttcgcctccg 738841 cttaatacgg agacgcggct ttcgatatgc tttgtcgtca gcccgcattt tgccagagcg 738901 gcacggattt catactgcgt ataagaaggg aattcgctcc atacttcttc gatgcacgta 738961 ttgttgtttg tttccttgac ctcttgctcg aaatagccgg tatagatgtg ctcaccgcgt 739021 tcaacagagc cttcgagcgg ctggatttca ccaagcaaac ttttcagcaa tgtcgttttt 739081 ccgatcccat tcgcgccgta aagggcgatt ttttggccgc gctccatgcg gaggttgagc 739141 ggacgggaca gcggggaatc gtaaccgatc acgagatcct tcgtttcaaa aatcagcttg 739201 cctgacgttc tcgccggctt aaagtggaat tccggctttg gcttttctgc cgcaagctcg 739261 atcatatcca tcttatcgag tttcttttgg cgggacatcg ccatgtttct cgtgctgaca 739321 cgcgctttgt tgcgggcgac gaaatccttc agctccgcga cttcctgctg ctgctttttg 739381 taggccgctt caagctgctg ttttttcacc tcgtagactt ccataaactg atggtagtcg 739441 ccgacataac gtgtcagctc ttgattttca acgtgataaa tcaggttgat gacactattc 739501 aagaacggaa tatcgtggga aatcaggatg aacgcgttct cgtattcctg caggtagcgt 739561 ttcagccatt caatatgctg ttcatcaaga tagttggtcg gctcatcgag aagcagaatt 739621 tccggctttt caaggagaag cttagcgaga aggacctttg tgcgctgtcc gccgctcaaa 739681 tcggtgacat ctcgctctaa accgatatcg ctcaaaccga gaccgcgggc gatttcttcc 739741 accttggaat caatgacata aaaatcattg tttgtcagcg cgtcttgaat gacgccgact 739801 tcttcaagca gcttctcgag ctcgtcggga tcagcctcgc ccattttgtt gtaaatctcg 739861 ttcatttcct cttccatcgc aaataaataa tggaatgcgt ctttcaggac gtcgcgaatg 739921 gattttcctt tttccagcac ggtatgctga tcaaggtatc cgacacggac attttttgac 739981 cattcgactt ttccctcatc aggttcaagc tttccggtaa taatattcat gaaggttgat 740041 tttccttcac cgtttgcgcc gatcaagccg acgtgctcgc cttttaacag gcggaaggaa 740101 acgttattaa aaatggcccg gtccccgaaa ccgtggctta aatcctttac agataaaata 740161 ctcatgttta cacctctatc gttatcaaac acgcacaatc ggcgtgtaat attcaccctt 740221 ttgattataa aggaggattc ggaatgttga aaggtatagg aaagaaaaag aaaaattgcg 740281 ttccgggcga ggttttgaga tactatggaa tagatttcag gaattgagga gaacaaaatg 740341 acgcaaactt ggccattttt acataatgca caatcattta tacaagagaa ttggaatgct 740401 tccggctttc aaaagccaac ccctgttcag gagcaggcag cccagctgat catggacgga 740461 aaggatgtca ttgcagaatc gccgacaggc acagggaaga cgctggcgta tgcgctgccg 740521 gtcttggagc ggatcaaacc agagcaaaag catccgcagg cggtgatttt agcgccttcc 740581 cgtgagctgg tcatgcagat ttttcaggtg attcaggatt ggaaagcggg ctcagagctg 740641 cgcgcggctt ccttaatcgg cggggcgaat gtgaagaaac aggtcgaaaa gctgaagaaa 740701 catccgcata tcatcgtcgg cacgccaggc agggtgtttg aactgattaa agcgaagaaa 740761 ctcaaaatgc atgaagtgaa aacgatcgtg cttgatgaaa cggatcagct cgtcctgccg 740821 gagcatcgcg aaacgatgaa gcaaatcatt aaaacaacat taagagaccg ccagcttcta 740881 tgtttttctg ccacgctcaa aaaggaaaca gaggacgtgc tccgcgaatt ggcgcaagag 740941 cctgaggtgt tgaaggtgca gcgaagcaag gcggaggcag ggaaagtgaa gcatcaatac 741001 ctgatttgcg accagcgcga caaagtgaag ctgctgcaaa agctgtcaag gcttgaaggc 741061 atgcaggcac tcgtatttgt gagagacatt ggcaacctga gtgtatatgc ggaaaaactg 741121 gcatatcacc acgttgaact cggcgttttg cacagtgaag cgaaaaaaat ggagcgagcg 741181 aaaatcattg ccacattcga agacggagag tttcctcttt tattggcgac tgacattgcc 741241 gcacgcggtt tagatattga aaacctgcca tacgtgattc atgctgatat tccagatgaa 741301 gatggctatg tccacagatc aggacgaaca ggccgggccg gaaaagaagg caacgtgctg 741361 agccttgtga caaaattgga ggaatctaag ctgaaaaaaa tggcgaagaa gcttggtgtt 741421 gagctgagtg aagctgtgta tgcaggcgga aaactgaaga cgaaataaaa agaagggcga 741481 agagcccttt ttttgttgta aaataataga aaagattttg cgcggaggtg ggaaaatggc 741541 ttcaatagac aggtttcaag taatgcagga gccagagctg aaaatccttg aacactggtt 741601 tgagaatgag gataccagac ggagaatgga tgggatgctg ctattagatg agtggtatgc 741661 acgagtaaat aaagataaac acgatactgt catcatggcg tatgatggac agctgccggc 741721 agggatggtc gttattgagt tcggagagga gcggacatat attggattga tcgtcaatcc 741781 tttgtaccgg cttaaagggt atggaaaaca gatactgcaa aagctgatga ccgaacctga 741841 ttttactagc gtgcgagaat gggtggcatg cattgaagaa gacaatcgaa tcagtttagc 741901 ttgctttcaa gcagcaggat tcactttaga agacacggaa cctgatgaag atggttttct 741961 tacgctgatt cttcgcaact gatctcatcg aaacacaaaa ggagggcaaa aagccctccc 742021 gttttcatct tcattcagct cggatcactg accttgatca gctgtttccc tttattttct 742081 cccttaaata aaccgagaaa cgcgtcagga atgttttcga agccttctgt gatggtttcc 742141 tcgtaatgga gtttaccagc cttcagccat tctgccagct gttttgctcc ctcagaaaaa 742201 cgatcggagt agtcgcttac gataaagcct tgcatcagcg acttcgtttt aatgagtttt 742261 gattggacac gagggcccat gtcatctgct tcgctttctg cgttatagga agaaatggcg 742321 ccgcacaccg gaatgcgggc aaattcattg agcagattca tcaccgcgtc tgaaatcggt 742381 ccgccgacat tgtcaaaata cacatcgaca ccgtcaggac aagcgttttg aagcgctttt 742441 tggatatcat ccgctgtttt gtaattgatg gcttcgtcaa actgaagctc ctgttttaaa 742501 tagtcgattt tttcatcaga gcccgcgatg ccgacgactc gcgcgccttt gattttggca 742561 atttgcccga ctgttgaacc gacggctccg gcagctcctg agacaaccac ggtttcgcct 742621 tccttcgggc gtccgatgtc cagcaatccg aagtatgctg ttaagccggt cattcccaaa 742681 atgccgagat aggccgaagc gggagcaagg cttgtatcaa tttttcgcaa ggcagactcg 742741 ctcacagcgg aaaattcctg ccagctgaga tttccgatga cgatatcgcc ttttttcaga 742801 tgattcccgt ctgacacaac ttcagcgata acccctccag aaagcgcttt atccaaggcg 742861 aacggctcaa catatgactt cgtatcctgc atacggccgc gcatataagg gtcaaccgat 742921 acataaagcg ttttgacaag cacttcccct tgcttgggtt caggaaccgg aatggtttca 742981 aagcgaaagt cttcatgaac aggaatacct tgtggacgtc ttgctaattg aatttgctgc 743041 tgagatgctg tcattttcat cctcctatca cttggttgac accactgtaa catggacagg 743101 agaggaaata caaaaggtaa gctggcatac aaaaaaggtt atagatgagc ttatgctttc 743161 tacaagctct tttgttttaa aagttctctt tagtcattta tcattattag aaaacagaac 743221 agaaaaagag ctcctgtaca cctagctaag attggctagt gtgtatgtcg attctttttc 743281 atattcttgc aagcatctgc gagggggagc ttagtcgttc acattttgct ttcgcatcaa 743341 tctgcaatag caaagtctat gcgatttttt tacatcagca aagatttgtt caattttttc 743401 cttttatgcc gagtttttct gaaacagata attgatggta ctcaaccatt ttcttttggt 743461 caataaagta atgtttactt attaattaaa cacgcgaaaa agcaaacgaa aacataatta 743521 aattttatat atttattaaa agcttatatg tttatttacc ttttttttga attgtaattg 743581 agaaaatcca tatattgcgg acactaataa aagaatacct gctgaaacat aaactaaacg 743641 aactccaagg aaatctgaaa tagcccctat agccagaatt gaaaacataa aaatgaactg 743701 tactaaagaa gaccttgcag acattatatt aattcgagtt tgctcggttg ttatgttctg 743761 aataagtgtt tcttgtgtaa gatctcttaa tatataagcc ggccccataa agagaaccaa 743821 aattagagct aagtatgaat tacttataaa accatatatt aaagttaaac ttccatatga 743881 gacagcgcca attaacataa aattaattaa cttattttga aatctctccg acagcttata 743941 tattataaat ccccctatca tcgaacctaa ataatatgct ccattaataa atccccacca 744001 tgattctcct ttatgcaaga cttcgttaac gaaagctaaa gagacagatc ctatccaaat 744061 cattcctgcc catgactcaa ttaaatccat aataataatt gttctaagtt tcttttggct 744121 aaataaatac cgccaaccac ttactatact cttattggga gaattttttt cacgtatgac 744181 agaattagcg tggccatgtg gtagacaaaa taaaagagaa agaagagatg taaacaacaa 744241 aaagatagta agtataatgg tatatccctc acctaaaaat gcaattatga gaccacctaa 744301 agaccagcct acaaattgaa aagtttggtc cactgtagat aataatccat ttgcttttac 744361 tcttctatca ggagagatta tttcccctat aattgcactt tttaaaggtg agaaccatcc 744421 attaaaaaag gaaatacagc taataataat aaagactaaa atgagagttt gattagagta 744481 agttcttaat aaagcataga acaaacatat taataacagc atttgtatca attgagaaat 744541 aattattgta agaggcagtt ttaatcgaat tgttattaac ggtaatatag cacttccaaa 744601 aatacgaaaa ataatactta ttaatgtcac catagaggcg atggttgtcg aattggtcat 744661 tttaaacaaa aacgaaatca ctaccatagt atatagagaa aaacctaaat ttgtagtggt 744721 ctggctaaat aaaatagaat aataaccttt actcatatgt atcctccctt ggaataattt 744781 ttctcggtaa agagcttaaa catatttaaa caccttaaaa caacaaaagt aaagaaaaaa 744841 tttccttgta aactatttac ttttattcta tttattgtta ttgtttattt aagttctctg 744901 actattctat caatattcag ggaaccacat atcttattaa aggggggaaa accatgagaa 744961 aattaagaaa aaactggaga aaatcgattg ttagcccggt tctttatact aatgaaaaat 745021 ggtaaacact tagggaatag catttaatgc tattccttat ttcaacaaac aaatcgggag 745081 gttatcgtaa tttgactcta ttaatgcaag atcataaatc aatttacaat aaagatatag 745141 aaatattaat tgaagttgaa gaacttatta cttctgttcc agaaaataaa aaaaatgatt 745201 ttaagagttt aatcgataat agaattatga ctctactaaa taaaattcaa caccctgtag 745261 cagcggaaaa tgtgtttggg atgtgtattg cttatccgaa tacttacata aggtatagat 745321 taattgattt cgttgaaaaa tgggtacctt atttctctgc tgtagaaact ataatcaatc 745381 taacccagga tccggatgat ttagtttctt ttaaagctat ggatgtctgt gcaaatcata 745441 aaattgaaga atctgtagca tatttgtctt cgattattga tgatgtccgg gagagtataa 745501 gctaccctaa aaaacctgtg ggattagggg cccaaaaagt attaagtaca ttattagata 745561 tattcggtgt tgaaaaacat gaagagctag taatgctaaa aaattatttt gatcaaaatg 745621 gtatacttcc taataacttt gactttgaag aaaaaattcc tcaaagtcta atagaggaat 745681 tcgaaaaaac agaagaagat gggatgattt taattccggg tggctttttt gaattcggtt 745741 taaatgaaaa tgaaattcct gacaaaacat ttaattggaa agatgctgtt cctagacaaa 745801 aagtatggtt acctccattt tttatcgata agtatcctgt tacaaataaa gattatgata 745861 tctttaccga gttcatagag gaaaatgggc atatattctg tcatcctaat gaaccgcaga 745921 ataaacaaca tagaagaaat acatattggg atgataggta tttagataat catcccgtta 745981 caggtataga tttttatgat gcatttgctt acgcaagata taaggggaaa gaattgccaa 746041 ccgagtttca atgggaaaaa gctgctcgag gcgaaaaggg taatgtctgg ccttggggag 746101 ataaatttga tcctgcaaag gttcaatatg ctggaagtct ttataatgaa cccattactt 746161 ctttaaagtc ctggagagaa aatttattaa aagctcatgc tgataaagaa ttaaatcatt 746221 taacaagtga tatttttgaa caaaatggtg aaagtcccta tggagtatgc ggtatgatcg 746281 gcggaacatg ggagtggact agaagtgagc ttaaaacaaa gagagctttc caccctattt 746341 ttgagaatgt accatttaat agtgttaact catttgccgt tcttaaagga ggatcattct 746401 tctctcatcc aggcttaatg ttcccttctt ttagagcaaa agatattcct ttctgtcgac 746461 acaatgaaat ggggattaga tgcgtaaaga atattccagt atataaaatt agagaatcaa 746521 ttaatgggcc aattactaat aaagcaattt attaatcatt ctaggttaga gacttgataa 746581 aagtatacta acattgtgta gtaatgttca gcttgtagaa aaaacaatgt tttttctaca 746641 agattttatt ttaaatgctt ttcaaaatta tcagggattg agaatcagaa aaagagccat 746701 taagctcgat cttagctagg tattacgatc ttctgtatat tattgtgaga aatatagaag 746761 attcagttag ttagcatttc gattttaagc tgagcctgca atagcaaagc atctgttttg 746821 attattcttt ttctgataca taagctaatt ttgtcgcttt tcttttttgt cttttcacgc 746881 atttcgagga tgacttacta taattctttc agcttttcta tgtgttaaga ttcgaataga 746941 tgaaataact ttaacaagtt ggtcaataag aacagattta actttatgtt aaaagagtat 747001 ctcgtataga acataagaag aatgacgagt tttttaagat tatcatcaat tatgtgagaa 747061 taaaatatta taagggaaaa tgaaggctgt cacgtttctc gacagcccta gggaattcct 747121 ctccttttca tttcgcccgt aatttcgggc acagtcccgt cggcaggcac attggcttct 747181 ggtcgatcgg gcttctcatg atgcagcatt ccaagccgaa gacttcacgg aaaaatggct 747241 gggtgaacac atcttccggt gttccggcgt tgtatatttt tccgtccagc acactgatca 747301 gatagtcagc atattgagcg gcttggttta aatcatggag caccatgaca acggtgcggc 747361 catggtcgcg gttcagcttt ttcagcagtt caagcacttc aatctgatgt gagatgtcta 747421 aatacgtggt cggctcatca agcaaaagca aatcagtgcc ttgcgcaagt gccatggaaa 747481 tccaggctct ttgtctttgg ccgcctgaga gggcatcaag tgtccgatcc ttcagttcaa 747541 tcatgcccgt tgcttccagc gcccactcta ccatgtcatg atcctcttgg gtatgcttgg 747601 ataacagctt tttgtgagga tgtctgccaa aatagcataa ttcctctacc gtcaatcctt 747661 caggagcctg aggagattgt ggaagaatgg ccagtttttt tgcgacttct tttgatggct 747721 ggcggtggat gtcttttcct tctagtagca ctgtaccgct ttttggggcc atcagcctgg 747781 cgagcgattt gaggattgtt gatttaccgc agccattagc gccgatgagc gcagtgattt 747841 ttccttcttc tatctttaag tcgactccgt caataatcac tgtactgtca tatgaaagag 747901 tgagctggtc tgcagccagt tttcccatgg tatcctctcc ctactgtttc ctcgcttcga 747961 atttcaataa atataagaaa taaggcgcgc cgatcacggc tgtcagtatt ccggcaggta 748021 tttcaaccgg aggcatgatg ccgcgcccta acgtatctgc aattaataat ataatagcac 748081 caatcaatgc cgatgcaggc agtaaatatt tagctttttc tccggtaagc cgtctggcga 748141 tatgcggagc aagcaagccg ataaaaccga ttgagccgac gacggctaca cagcttcccg 748201 ccagcgccac cgcggtgaaa atcaggatga atctcagccg gtttgcgttt tctccgagac 748261 cctgtgcaag ctcatccccg agtgacataa gatccagctt cggtatgagt atgcagacga 748321 tcggaaaaag aatcaaaagc catggcgcaa gcagcttgac ttcttcccag tttcttcccc 748381 agaggcttcc tgtcagccaa atgagtgcag cattcacgtc gcctggaaac ttgaccatca 748441 tatattgcat tccggcgtgg cagaccgcgc ctaaagcaat gcctgataaa gccagtgaag 748501 agggctgaat gctctttttt cgggctatca ttaataatag tacagcaata atggcggctc 748561 cggcaaatgc ggagaacgga agcacgtata ccggcgactc aggaaagatg agaatcacag 748621 ccatcgccgc aagtccggag ccttttgaaa tgccgacaac gtccggggaa gcgagcggat 748681 ttcggatcac accctgtaaa atcgctccgg cagcggcaag tccagcacct gccaaaatcg 748741 ctaatataat gcggggaagg cgatattgct ggatgataaa ttcaaaggaa tgatccagtc 748801 ccagcagatt cgtcactacc gcatcaggtg aaatgtataa tgcaccgatt ccaatgctga 748861 tgacggacag aacgattaaa atcacggcca atatgagtat cgccagtaag gggcgttttt 748921 gttttctggt tgttttcttc atttcaggtt tcgccctttc cttgccaaat ataagaaaaa 748981 cggcgttccg ataatcgcgg tgacaatgcc gaccggtgat tcataaggaa atgcaatcca 749041 tctggccaga acatctgcgt acaccagcaa aatggcaccg aacagtgccg aaaacggaag 749101 cacgtattga taatgttctc cgatcagctt gcggacaata tgcgggacga gcagcccgac 749161 aaagccaatc ggcccggcga cggctacgga agcgccggaa agaattaaaa taatcaaact 749221 gatcagaatc ctgatgccgt tcatattttg tccaagccct tttgctgttt cgtctccgag 749281 accgagaaca gaaacagaac cggaaaatac gagggcaagc ccgatgccaa tgacagaaaa 749341 aggagcgatg gttatgacgt cctgccagtt gctgccgtcg attgcgcctg tcatccagta 749401 cagaacatcc tcacctgact catttaaaat aatgatggcc tgtgtcatag aggagaggaa 749461 caagtgcacg gccattcctg acagcgccag cttgacaggc gtcattccgc cggatgaggc 749521 aatcatatac acaatcgcgc cgcctgctgc cgcacccgca aaagcgaata taacagatga 749581 atagggcgat gccggcagaa tgacgagaga agcaacaaca aaaagcgatg cacccgcatt 749641 cacaccgaaa atttggggtg aagccagagg atttctggtc atagcctgca tcagcgcccc 749701 tgctacagct aggctggcgc cgacaaaaac gccgattaat gtgcggggaa ggcgaagagt 749761 agagatgatg agctgttcct ttgaaccgtc ccatacaaaa agatatttca atgaatctat 749821 gatgctgatg tctgaggctc ctactgaaag attcagccca agcccaaata taaaaataat 749881 cagtgcaatg ataaacatca tcagtcttga tgatgagcgc cgtttggctg aatgatacaa 749941 cagtctcact tccttactgc gtctggttgc aaaaacgaag aagcaaggat tcccctcgct 750001 tctcatttgt cctatttatt atacactttt ttaagcacat ctttggcgct tgtttcacta 750061 gacttgatgc ctctgaatct tgtccaagtg tcacggtccg catcatagac ttgtccattt 750121 ttcaccgctt tgagattttt ccagagcggg ttcgttttcc actcatctac aatggttttg 750181 ccttcgttgg ctgagatgaa caaaatatca ggatcgattt tgctcaattg ctcaaggctg 750241 acctcttgat aggcgttatc tgacttcaca gcgtgtgtaa agcctagcat tttaaagatt 750301 tctccgtcat aggatgatga tgtatgaagc tggaaggaat ccgctcttgc aacgccgaga 750361 acgatgttgc ggttttcatc tttcggaagt tcggctttta gatcgttgat gacttttttg 750421 tgctcggcaa gcttttcttt tccttcatct tctttattta atgctttagc aatggtcgta 750481 aagctgtcga tcgtttcgtc atatgtcgct tcacggcttt ttaattcaat cgtcggggcg 750541 atttttttca gctgtttata aatgttttta tggcgctcag cgtcagcgat gattaaatca 750601 ggcttcaagg aactgatgac ctcaagattg ggttcgctgc gtgtgcctac agatgtgtaa 750661 tcaatggagc tgccgacaag ctttttaatc atatcttttt tgttgtcatc tgcgatgccc 750721 accggcgtaa tgccgagatt gtgaacggca tccaagaatg aaagctcaag cacaaccacc 750781 cgcttaggtg tgccgcttac tgtcgttttt ccttcttcgt catggatcac tctggaatcc 750841 ttagactcgc ttttgccgct tccgttgtta ttctggcttg atgaacagcc ggatacaatg 750901 aggcaggcga gcaataaaac actcatgatg gcaatcaact tgttagaata ggtgcgcatg 750961 tcattcttcc ttttttcaga tttagtaatg agaatcatta tcacatgtaa cactataata 751021 gcatggctta tcatgtcaat atttttttag taaagaaagc tgcgttttta ctgctttctc 751081 atgaaagcat catcagacac aaataagtgg tatgcagcgt taccgtgtct tcgagacaaa 751141 aacgcatggg cgttggcttt agaggtttcg aacatatcag cagtgacata aggaaggaga 751201 gtgctgagat aaccggacaa tttcttttct atttcatctg ttagtgcaaa ttcaatgtcg 751261 ccgatattca tgataatcga gaaaacaaag tcgatatcga tatgaaaatg ttcctcggca 751321 aaaaccgcaa gctcgtgaat tcctggtgaa catccggcac gcttatggaa aatctgtttg 751381 actaaatcac tcacaatcca agcattgtat tgctgttctg gtgaaaagta ttgcattaga 751441 catacctcct gctcgtacgg ataaaggcag cgtttcatgg tcgtgtgctc cgtgcagcgg 751501 cttctcctta attttgattt ttctgaaaat aggtcccgtt cctatcactt taccatggac 751561 ggaaaacaaa tagctactac cattcctcct gtttttctct tcaatgttct ggaatctgtt 751621 tcaggtacag acgatcgggt atgaaagaaa tatagaaaac atgaaggagg aatatcgaca 751681 tgaaaccagt tgtaaaagag tatacaaatg acgaacagct catgaaagat gtagaggaat 751741 tgcagaaaat gggtgttgcg aaagaggatg tatacgtctt agctcacgac gatgacagaa 751801 cggaacgcct ggctgacaac acgaacgcca acacgatcgg agccaaagaa acaggtttca 751861 agcacgcggt gggaaatatc ttcaataaaa aaggagacga gctccgcaat aaaattcacg 751921 aaatcggttt ttctgaagat gaagccgctc aatttgaaaa acgcttagat gaaggaaaag 751981 tgcttctctt tgtgacagat aacgaaaaag tgaaagcttg ggcataaagc aaggaaaaaa 752041 ccaaaaggcc aatgtcggcc ttttggtttt tttgcggtct ttgcggtggg attttgcaga 752101 atgccgcaat aggatagcgg aacattttcg gttctgaatg tccctcaatt tgctattata 752161 tttttgtgat aaattggaat aaaatctcac aaaatagaaa atgggggtac atagtggatg 752221 aaaaaagtga tgttagctac ggctttgttt ttaggattga ctccagctgg cgcgaacgca 752281 gctgatttag gccaccagac gttgggatcc aatgatggct ggggcgcgta ctcgaccggc 752341 acgacaggcg gatcaaaagc atcctcctca aatgtgtata ccgtcagcaa cagaaaccag 752401 cttgtctcgg cattagggaa ggaaacgaac acaacgccaa aaatcattta tatcaaggga 752461 acgattgaca tgaacgtgga tgacaatctg aagccgcttg gcctaaatga ctataaagat 752521 ccggagtatg atttggacaa atatttgaaa gcctatgatc ctagcacatg gggcaaaaaa 752581 gagccgtcgg gaacacaaga agaagcgaga gcacgctctc agaaaaacca aaaagcacgg 752641 gtcatggtgg atatccctgc aaacacgacg atcgtcggtt cagggactaa cgctaaagtc 752701 gtgggaggaa acttccaaat caagagtgat aacgtcatta ttcgcaacat tgaattccag 752761 gatgcctatg actattttcc gcaatgggat ccgactgacg gaagctcagg gaactggaac 752821 tcacaatacg acaacatcac gataaacggc ggcacacaca tctggattga tcactgtaca 752881 tttaatgacg gttcgcgtcc ggacagcaca tcaccgaaat attatggaag aaaatatcag 752941 caccatgacg gccaaacgga tgcttccaac ggtgctaact atatcacgat gtcctacaac 753001 tattatcacg atcatgataa aagctccatt ttcggatcaa gtgacagcaa aacctccgat 753061 gacggcaaat taaaaattac gctgcatcat aaccgctata aaaatattgt ccagcgcgcg 753121 ccgagagtcc gcttcgggca agtgcacgta tacaacaact attatgaagg aagcacaagc 753181 tcttcaagtt atccttttag ctatgcatgg ggaatcggaa agtcatctaa aatctatgcc 753241 caaaacaatg tcattgacgt accgggactg tcagctgcta aaacgatcag cgtattcagc 753301 gggggaacgg ctttatatga ctccggcacg ttgctgaacg gcacacagat caacgcatcg 753361 gctgcaaacg ggctgagctc ttctgtcggc tggacgccgt ctctgcatgg atcgattgat 753421 gcttctgcta atgtgaaatc aaatgttata aatcaagcgg gtgcgggtaa attaaattaa 753481 gaaagtgaaa aacacaaagg gtgctaacct ttgtgttttt taattaatta aaatgtttat 753541 taacttagtt aaggagtaga atggaaaagg ggatcggaaa acaagtatat aggaggagac 753601 ctatttatgg cttcagaaaa agacgcagga aaacagtcag cagtaaagct tgttccattg 753661 cttattactg tcgctgtggg actaatcatc tggtttattc ccgctccgtc cggacttgaa 753721 cctaaagctt ggcatttgtt tgcgattttt gtcgcaacaa ttatcggctt tatctccaag 753781 cccttgccaa tgggtgcaat tgcaattttt gcattggcgg ttactgcact aactggaaca 753841 ctatcaattg aggatacatt aagcggattc gggaataaga ccatttggct tatcgttatc 753901 gcattcttta tttcccgggg atttatcaaa accggtctcg gtgcgagaat ttcgtatgta 753961 ttcgttcaga aattcggaaa aaaaaccctt ggactttctt attcactgct attcagtgat 754021 ttaatacttt cacctgctat tccaagtaat acggcgcgtg caggaggcat tatatttcct 754081 attatcagat cattatccga aacattcgga tcaagcccgg caaatggaac agagagaaaa 754141 atcggtgcat tcttattaaa aaccggtttt caggggaatc tgatcacatc tgctatgttc 754201 ctgacagcga tggcggcgaa cccgctgatt gccaagctgg cccatgatgt cgcaggggtg 754261 gacttaacat ggacaagctg ggcaattgcc gcgattgtac cgggacttgt aagcttaatc 754321 atcacgccgc ttgtgattta caaactgtat ccgccggaaa tcaaagaaac accggatgcg 754381 gcgaaaatcg caacagaaaa actgaaagaa atgggaccgt tcaaaaaatc ggagctttcc 754441 atggttatcg tgtttctttt ggtgcttgtg ctgtggattt ttggcggcag cttcaacatc 754501 gacgctacca caaccgcatt gatcggtttg gccgttctct tattatcaca agttctgact 754561 tgggatgata tcaagaaaga acagggcgct tgggatacgc tcacttggtt tgcggcgctt 754621 gtcatgctcg ccaacttctt gaatgaatta ggcatggtgt cttggttcag taatgccatg 754681 aaatcatccg tatcagggtt ctcttggatt gtggcattca tcattttaat tgttgtgtat 754741 tattactctc actatttctt tgcaagtgcg acagcccaca tcagtgcgat gtattcagca 754801 tttttggctg tcgtcgtggc agcgggcgca ccgccgcttt tagcagcgct gagcctcgcg 754861 ttcatcagca acctgttcgg gtcaacgact cactacggtt ctggagcggc tccggtcttc 754921 ttcggagcag gctacatccc gcaaggcaaa tggtggtcca tcggatttat cctgtcgatt 754981 gttcatatca tcgtatggct tgtgatcggc ggattatggt ggaaagtact aggaatatgg 755041 tagaaagaaa aaggcagacg cggtctgcct ttttttattt tcactccttc gtaagaaaat 755101 ggattttgaa aaatgagaaa attccctgtg aaaaatggta tgatctaggt agaaaggacg 755161 gctggtgctg tggtgaaaaa gcggttccat ttttccctgc aaacaaaaat aatggggctg 755221 attgcggctc tgctggtctt tgtcattggt gtgctgacca ttacgttagc cgttcagcat 755281 acacagggag aacggagaca ggcagagcag ctggcggttc aaacggcgag aaccatttcc 755341 tatatgccgc cggttaaaga gctcattgag agaaaagacg gacatgcggc tcagacgcaa 755401 gaggtcattg aacaaatgaa agaacagact ggtgcgtttg ccatttatgt tttgaacgaa 755461 aaaggagaca ttcgcagcgc ctctggaaaa agcggattaa agaaactgga gcgcagcaga 755521 gaaattttgt ttggcggttc gcatgtttct gaaacaaaag cggatggacg aagagtgatc 755581 agagggagcg cgccgattat aaaagaacag aagggataca gccaagtgat cggcagcgtg 755641 tctgttgatt ttctgcaaac ggagacagag caaagcatca aaaagcattt gagaaatttg 755701 agtgtgattg ctgtgcttgt actgctgctc ggatttattg gcgccgccgt gctggcgaaa 755761 agcatcagaa aggatacgct cgggcttgaa ccgcatgaga tcgcggctct atatcgtgag 755821 aggaacgcaa tgcttttcgc gattcgagaa gggattattg ccaccaatcg tgaaggcgtc 755881 gtcaccatga tgaacgtatc ggcggccgag atgctgaagc tgcccgagcc tgtgatccat 755941 cttcctatag atgacgtcat gccgggagca gggctgatgt ctgtgcttga aaaaggagaa 756001 atgctgccga accaggaagt aagcgtcaac gatcaagtgt ttattatcaa tacgaaagtg 756061 atgaatcaag gcgggcaggc gtatgggatt gtcgtcagct tcagggagaa aacagagctg 756121 aagaagctga tcgacacatt gacagaggtt cgcaaatatt cagaggatct cagggcgcag 756181 actcatgaat tttcaaataa gctttatgcg attttagggc tgcttgagct tggggagtat 756241 gatgaagcca ttgatctgat taaagaggaa tatgcgatac aaaatgaaca gcatgatctt 756301 ttattccata acatccattc gcagcaggtg caggccattt tgttagggaa aataagcaag 756361 gcatcggaaa agaaggtcaa gctggtgatt gatgagaaca gctcactcgc gcctcttcct 756421 gcgcatatcg gcttgtccca tcttattacg attattggca atttaattga taacgctttc 756481 gaagctgtag cggagcaaag cgtgaaggaa gttttgtttt ttatcacgga tatgggccat 756541 gacattgtca ttgaagtatc agacacaggg cccggtgtgc cgccagagaa aatagaagct 756601 gtgtttgaga gaggctattc ttcaaagggg atgaggagag gctacggtct ggccaatgtg 756661 aaagactcag tgcgtgaact gggcggctgg atcgaactgg cgaatcaaaa aactggcggg 756721 gcggtattca ctgtatttat accgaaggag aaacaaaggg ggaatccatt tgattcacat 756781 cgcgattgcg gaggatgatt ttcgagttgc gcaaatccat gagagattga ttaaacagct 756841 tgatggattc aagattatcg gcaaggcggc taacgcaaaa gagacattgg cgcttttgaa 756901 ggaacacaag gctgatttgc ttctgctgga tatttatatg ccggacgagc ttgggaccgc 756961 gttgattcct gatatacgaa gccgatttcc tgaagtggac attatgatta tcacagcggc 757021 aacagaaacc cgtcatttgc aggaagcgct aagggcggga attgcccact atttgatcaa 757081 acccgtaaca gctgacaagt tcaggcaggt gctgcttcag tataaagaaa aaaggaagct 757141 gctcatgtct cagccggagg tcagccaatc catgatcgac catatttttg ggaacggtgt 757201 gaagacagct ttgccggcag aggatttgcc gactggcatt aattcgatta cactgcgaaa 757261 aattaaggaa gcgcttcaga ctgcgtcaga aggattgaca gcggaggaac ttggggaaaa 757321 aatgggggcg tcacgaacaa ctgcccgccg ttatgccgag taccttgtgt caaaggaaga 757381 agcaagagcc gagcttgaat acgggattat cggcaggccg gagagaaaat attatttggc 757441 ggcggattag atatgaaaaa atctataatc ctattgaata ttctattgat ctttatgcag 757501 ggtgatatca ggcaggcggc tgcgccgcgc ctgccggacg ggccgataga aattgtcgtc 757561 cctgccgaac cttctggcgg ctgggatgtc acagcgcagg cgatccaatc agttttgagg 757621 cagaagcaga tcgtgaagga tgatgttcat atcgtctata aatccggcgg cgggggagag 757681 aaaggctgga aatatgtcaa caaaagcagc aaacaaacca tcagcatgac gtccagccta 757741 atattgagca atgatcttct cgggcaaagc aaattaaaaa tgtccgattt tacgccgctc 757801 gccattctct ccaaggaatg gcagacggtt gcattgccaa aaggatcagc gttaacaaat 757861 ggcaaggatg tgctgaatga gatcaacatg catcccggca aggtgagaat cggctttgcc 757921 ccggggtttg gcaatgatga tcagctctcg ttcgtcagag cggcagatat gtacggcatt 757981 gacccgtttg acattcaatt ctcacagtat gacagcagcg aacagctcat tcaggcgctg 758041 atcagacatg agatagaagc ggcttccatg acactttctg aagcgaaacc atatgaacga 758101 aacggcgata tcacgttagc cgctgtaacg tctgataaaa gacttcccgg ttttccaaat 758161 gtaccgacgt ggaaggagca gggaatcccg tttgtttttt ctcattggag agggattttg 758221 ggcccgaaaa atatgtctga ggaagagatt tcttactggg atcaagcgct aaagaaggtc 758281 acctcctcac ctgaatggaa gcggaaaata aacgaacagg actgggaaag cttttattta 758341 aacagcaggg aaacgaaacg gtttttagaa gagcaatctg ctttttatca aagcatcatg 758401 acaggaaatt aaaatcccga catcccggga tttttttcat gccgaaaatt gatcaaaaag 758461 aacaaaacgg ttttaaaaaa ttaaaaatac aaaaaaacca aattatttac ttgcggttgg 758521 ttttcccata cgatggcaaa aaggcaagac aaaaagggga gtaagggaga aaaaaatgta 758581 agcggattca tttaaggggg aatggatgtg ttagcaatct taggctttct catgatgctt 758641 gtgtttatgg cattgatcat gacaaaacgg ctttctgttt taacagcatt agttttgacg 758701 ccgattgtgt ttgcgcttat cgccggattt ggatttactg aagttgggga catgatgatt 758761 tcggggattc agcaagtcgc gccgactgcg gtcatgatta tgtttgcgat cttatatttt 758821 ggaattatga ttgatacagg cctgtttgat ccaatggttg gcaaaatttt aagcatggtc 758881 aaaggagacc ctttaaaaat tgttgtcggg acagcggttc ttacaatgct cgtcgccttg 758941 gacggagatg gctcgacaac gtacatgatt acgacaagcg ccatgcttcc gctctatttg 759001 ctgctaggca tccggccaat tatcttggca ggaatcgcgg gagtcggcat gggaatcatg 759061 aacacgattc catggggagg tgcgacgccg agggcggcga gtgcgctggg ggttgatcca 759121 gctgagctta cagggccgat gattcctgtc attgcaagcg ggatgctttg tatggtggca 759181 gttgcgtatg tgcttggaaa agcggaacga aagcgccttg gtgtgattga actgaaacag 759241 ccagccaatg ccaatgaacc ggctgctgcg gttgaagatg agtggaagcg gccgaagctt 759301 tggtggttca atttattgtt aacgctttct ttaataggat gtttagtatc gggtaaagtc 759361 agtttaaccg tactgtttgt cattgcgttt tgtattgcgc tgattgtgaa ttatcccaat 759421 ctcgagcatc agagacagcg catcgcggcg cattccagca acgtgctggc tatcggttca 759481 atgatttttg ctgcgggggt gttcacgggg attttgacag gcacgaaaat ggttgatgaa 759541 atggcgatct cgctcgtgtc catgataccg gaacaaatgg gcggattgat cccggcgatt 759601 gttgccttaa caagcggcat tttcacattt ttgatgccga atgacgcgta tttctacggg 759661 gtgctgccga ttttatcaga aacagctgtc gcatacggtg tggataaagt ggaaattgcc 759721 agagcctcta ttatcggcca gccgattcat atgctgagtc cgcttgtgcc atccactcat 759781 ttgcttgtcg gactcgtcgg agtttctatt gatgaccatc aaaaattcgc attgaaatgg 759841 gcggttctcg cagtgatcgt catgacggct atcgctctat tgatcggtgc gatctctatt 759901 tccgtatgat aattcaggcg taatgacaca cactaacggc atacaacatt ccggaggtgt 759961 cattatgagt gatccttata tgccgctgac ttcagtcaga agcggagcgg ggttcgaagc 760021 ggcaaaaggg gtgcacggcc tgactgtgca aattgcgaat gtctatttta ttcagctgcc 760081 ttctgaacct cactcatttg ttttaattga tgccggcatg ccccaatcag ccggcgtgat 760141 tgtcaatgaa gccaaacaaa gattcggtga agggtttcag ctgaaggcga ttatcctcac 760201 acacgggcac tttgaccata ttggggcaat cgaagagatc cttgagcatt gggatgtgcc 760261 tgtttatatc cattctcggg aaatgcctta tgtaacaggt aaagaggatt atcctccggc 760321 tcgtcctgac agcaagagcg ggctggtcgc taagctgtcg ccgctgtttc cgcggcactc 760381 tatcgatatt tcctcacatg tccaggcact gccggaagac ggttcagttc cttttcttga 760441 cgagtggatg tggatcgcga caccaggaca cacgccgggc catatttcgt tattccgcga 760501 tgacggccgc gtgcttgtgg caggtgatgc tgttattaca gtggaacagg agaaaatggc 760561 tgacgtcttg atacaaaaac aggagcttca cgggccgccg gcttatttca cgcctgacac 760621 agagacggcc gctgagtcca ttctaaagct ggccggtctt gaaccggaag cgttattgac 760681 cgggcacggc ataccgatga ccggcaaaaa ctttcgaagt gacttaactg aattggcaaa 760741 tcggttatcg tctatttgac acccgcacca cgcgggtgtt ttttattgtt ttccaggaag 760801 ttgcagaaaa atcatttgtc ttgccgctta aaaacgatac aatgaaaagc atgaagtgat 760861 gtgaagggga gagtttgttg gaagaaaaag aaatactctg gaacgaagcg aaagcgttta 760921 ttgccgcatg ctatcaggaa ttgggaaagg aggaggaagt gaaagaccgt ctcgcggaca 760981 ttaaaagtga aattgacctg accggaagct atgtacatac gaaggaagag ctggagcacg 761041 gagcgaaaat ggcttggaga aacagcaacc gctgcatcgg cagattgttc tggaattcgc 761101 tgaatgttat cgacagacga gacgtccgga cgaaggagga agtgcgtgat gccctctttc 761161 accatattga aaccgccacc aataacggga aaatcagacc gaccattacg attttccctc 761221 cggaagagaa gggtgaaaag caagtcgaga tctggaatca tcagctgatc cggtacgctg 761281 gatatgagtc agacggagaa agaatcggcg acccggcttc ctgttccctg acagcagcct 761341 gcgaagagct cggctggcgc ggagagcgaa cggattttga cctgctgccg ctcatttttc 761401 gcatgaaagg ggacgagcag cctgtctggt atgagctgcc gcgttcactt gtgattgagg 761461 ttccaatcac acatccggac atcgaggcgt tttctgattt ggagctgaag tggtacggcg 761521 tgcctattat ttctgatatg aagcttgagg tcgggggcat tcattataat gccgcgccat 761581 ttaacggctg gtatatgggc acggagatcg gagcgagaaa cctcgcagat gaaaagcggt 761641 acgacaagct caaaaaagta gcgtccgtga tcggcatcgc cgctgattac aatacggatt 761701 tatggaagga tcaagcgcta gttgaattga ataaagctgt gctgcactcg tataaaaagc 761761 agggtgtcag catcgttgac catcatacag cggcaagcca gtttaaacgg tttgaagaac 761821 aggaggaaga agcgggcaga aagctgacgg gggactggac gtggctgatt ccgccaattt 761881 cacccgctgc cactcatatc ttccaccgct cctatgataa ctcaatcgtt aagccgaact 761941 atttttatca agataagcct tatgagtaaa caatagaaaa tcgatgatgg ccttcaaggc 762001 tgcgggattc agtcacagag atgtcggtaa cctttgagaa agggcttccg ttctttacag 762061 cctcaacaaa cgattgcagg gcgttttccg gaccctctgc caaaatctcg acacgcccgt 762121 catcacggtt tttgacccag ccggccagtt ttcgcttatc agcttccatt tgaacaaaat 762181 agcgaaagcc cacaccttga acccggccgt ctacaatgat tcggtattga agcatgtaaa 762241 aaccaccttt tctttttatg ataatcaatc attttacaac ctgtaaaggg gatgtgtttg 762301 tatgaaacaa gagcgctatt cagttctttc tcttaatctg ggaaaaccgc agacgcttga 762361 atatgacgga aagaaaatcg aaaccggcat catgaagcgg ccggctaaat cagccgtcat 762421 gctgtatcgg gagaattttg aaggagacgg acaggcggac ctcgtcaacc acggcggacc 762481 tgataaggct gtctgtgtct acccggcgga gcattatccg ttttgggaag agttcctctc 762541 aagaccgctg tcaaatgccg catttggaga aaatctgacg gtcgcgggcc tgactgagga 762601 gaatgtttgc atcggggatg tgttcagact tgatgaagct gttgttcagg tcagccagcc 762661 gcgccagccg tgtgtaaagc tggcgaaaaa gtttggtgta aaagaaatgg tgctgaaggt 762721 ccagcaaacc ggctatacag ggttttattt tcgcgtgctg gaggagggca gggtgtctcc 762781 cggcgcgaac cttgaattgc tgtccagagg agagaaaggc atatccgtcc agttcgcgaa 762841 ccgcatcaac taccatgatg caaaaaatct caccgccatt gaacggattt taagtgaggc 762901 tgcactatcg gaaagctgga gagcgtcctt tatgaaaaaa aaggacaggc tgctgccggt 762961 tgaatagaaa aaagccgcgc atatcaacgt gcgcggcttt gccatattta agattgtttt 763021 ttctttgatt caagcaggtt ggcaagaaaa taggttttat agctttgaag ctttcttcct 763081 tcatggtgcg tgatcccctg cttttttagt tctgccacat accagccttt actgccgtaa 763141 tgcatgtcag aaaactcctt tccctatctg atttcgaaac gattggcatt gtaacatcta 763201 taaaaagatg ctgaaaagag atgcggggaa aactgagcct ttcgcactag atgtacgaat 763261 gttcttctga atgtatatgc ggagcaaaag ccgaatatga tttaatggcc ggttagtttg 763321 atcatgacaa cgccaaatgt cataatggcg aaaacaatgc cgatatatgt gagcatcccg 763381 ttttttttct taacgccgta aacggtcata atgatgcctt caatgaaaaa aatgatgccg 763441 aaaataataa accacatgca gataaaggct cctttcacag acataatagt agtgtagcat 763501 atctgaaaga gccgggctgt gacaatatca agaaagccgg gcgcatatcg cccggctcat 763561 gttttattgt ttatcaacca atttgaccag aagctgtgcc aaatgttctt tctcatcttc 763621 gtctgcaacg ctccaaagct cttgcagcag catttcttca ccgttttgcg gctcttcatg 763681 ctttgcgagg tagtctccca ggatcgcagc gctttttaca agcttgccgt catccaatcc 763741 cagctttttg cctcggttga cttgtttttt caggtagcct ttaaattcct caaagtcttt 763801 taaaatgtct tcttttattg tgccatgcat cgcgttcatt tcgttttcaa tttggatttt 763861 ttcttgatct ctgttcattg caagacctcc tcgtacagaa taatgatgct ttacctgcaa 763921 ttggaggagg ttaaacctgc cggaagcccg gaatgtgttt tacagtttcg tcaggataat 763981 cggttcatct tttgtgatga cgatcgtgtg ttcaacttgg gcaaccatgc ttttatccgg 764041 cgtcttgaac gtccagccgt ctccagcttc aacaatcgtt tctgctttcg ttgaaataaa 764101 cggttcaagc gcgatgactg tgccattttt gaacagcgca ttatcaaacg gatcataata 764161 gttcatgatg tggttcggcg cttcatgcag gcttcggccg attccgtggc cggtcagggt 764221 tttgatgacg gtaaagcctt gagagcgtgc ttcatgataa acggctcttc cgatctggtt 764281 ttggcgcttg cccgcttttg cctgctgaag ccccttttga aaagcgtttt ccgcgcattg 764341 gcaaagctta tgaaggcgtt cttctccttc accgagcaca aatgagatgc ctgtgtcgga 764401 atagaagccg ccaaattcag cggagatgtc gatgttgaca aggtcccctg cttttaaaat 764461 tttggatgtg cttggtatgc cgtgagccac ttcatcattt acgctgatac atgtcacacc 764521 tggaaaatcg tattccttct caggagctga aacggcgccg tgctcatcaa gcacagcttt 764581 tccgataagg tcaaggtctt ttgtgctcat gccgggctct gccttccgct tcatttcttc 764641 acgcgcaagc gcgacgattc ttccgatttt tttcaggcct tctaattctt gatcgtttgt 764701 tacaatcatc tgtcattccc gctttctttt taaataatct agattaagct taccacaact 764761 gtcttaaaaa taggaaacac acggacctgg gaaaaaagaa atacccccgg gaaaattggt 764821 atagatcact agatatctta tatggtatat ttgaaaaaaa agggtatgag ggggatgggt 764881 atgctttcat ttttacaaaa actcgggaag tcatttatgc tcccgattgc ggttctgcct 764941 gcggttggaa ttatccttgc gcttggcaga gaggatgtat ttaatatccc gtttgtctat 765001 caggcgggga cggcggtttt tgatcatctg ccgcttattt ttgcgatcgg tattgccatc 765061 ggcatttcaa aagacagcaa tggggcagcg ggtttatcag gggcgatatc gtatctgatg 765121 cttgacgcgg caacaaagac aattgataaa acaaataaca tggcggtgtt tgggggaatt 765181 attgccggtt taattgccgg ttacacctat aaccgcttca aggataccaa gctgcctgaa 765241 tatctcgggt tcttcagtgg cagacggctt gtgccgattt taacagccat tattacgatc 765301 attttagcgg gcatattcgg agtggtctgg ccgccgattc aatcgtgtat caactcgttt 765361 ggagagtgga tgctcgggct cggcggcatc ggggcaggca tattcggcct attcaacagg 765421 ctgttaattc cgcttggcct tcaccatgtg ctgaacaata ttttctggtt ccaattcgga 765481 gaatataacg gagtgacagg ggatttggcg cgctttttcg cgaaagatcc gactgcgggc 765541 acatatatga ccggattttt cccaatcatg atgttcggtc ttccggcggc gtgtctggct 765601 atggttgtga ctgcgaagcc gtctaaacgg aaagcgacgg ctggaatgat gattggattt 765661 gctttaacgg cgtttatcac agggattacg gagccgattg agtttgcatt tatgttttta 765721 tctccgcttt tatacgctgt tcacgcggtc ttaaccgggt tatctttatt tatcgtcaac 765781 tggctcggca tccgctcagg cttctctttt tcagccggag ctatcgatta tgtgctcagc 765841 tatggaatcg cggaaaaacc gctgcttctg cttttggtag gtatatgcta tgcggcagta 765901 tactttatcg tgttttatgt actgattaag gctttgaatt taaaaacgcc tggacgggaa 765961 gacgatgatg tggatgaagt gctggatgaa aatactgttc aggatgtaaa tgaaaacatc 766021 atgctgaaag ggctcggcgg aaaagaaaac cttcaaacca ttgatcattg cgccacaagg 766081 ctgcgactga ctgtgaagga taccgctttg gtggatgaag cactgctaaa gaaagcaggc 766141 gcaaaagggg ttgtcaaatc gggcgggcaa tcggttcaag tcattattgg cccgaatgtg 766201 gaatttgcag ctgaggaatt gagggctgct gtcaaataaa aaagcggaga gggcaacctc 766261 tccgcttttt cttatttatc ttcgttatcc tttgacgttt cggaagaatc ttcgtcatgt 766321 tttgtgtaat cataatcaga aggattcacc ttcttaaaac ctttcggctc gtagaaccgc 766381 agcaggtctc cgtttatgat tttatcggac atttcaagtt ccttcttgac gagtgagtct 766441 tctgacttgt cgacttcgga ttcatcgagt tcttttccgg ttttcgtgtc gtaatactta 766501 ccggatattt tcgtgtactt cggtgaaata aagtctccgt ttcggaacgg aatcacttca 766561 cggtgttctt tcgataaaat atcagaaccg gacatcagat agtccttcgt atccactccg 766621 agcagatgca gaatggtagg agccacatca acgtctccgg catatttatg aactttctcg 766681 cccttcacgc cggcagcgtg gataaagagc ggcacccgtt gaagctgggc gttgtcgtaa 766741 tcagtgattt catccttgcc aagcactttc gccatcgctt tattgtggtt ttcagagatg 766801 ccgtagtggt ctccgtacat cacaataatc gatttatcat ataacccgtc ttttttcaga 766861 tcattgaaga attgttcaat ggactgatca aggtaatggg ctgactggaa atagttatcg 766921 acgacagagt caccaaagtc tccagccggg aagtctgtat ccccctcatc cattccgaat 766981 gggaagtggt tggaaagggt aatgaacttc gtatagaacg gctgcggcag gctttccagc 767041 agcggcattg attctttgaa gaacggtttg tctttcatgc cgtagttttt cgtgttttct 767101 tcgttcatgt catagtaagc agaatcaaag aatttatcaa tgccttccgc cttgtacatt 767161 tcgttacggt tccagaacgt ctgcgtgttc ccgtggaaag tagcagatgt gtaattctta 767221 gacttcagaa tcgccggaac ggattgcagc gtgttttgcg ctttgtttac gaaaactgaa 767281 ccttgagcca gcgggtacag agagttttcc atcataaatt cagcatcaga tgttttacct 767341 tgtcccgttt ggtggaaaaa gttatcaaag tagaacgttt cgttatcatg tgccagttta 767401 tttaagaatg gtgtcacttc tttgccgtca attttatagt cgatgataaa tgactgcaaa 767461 gattcaagtg aaacgtaaat gacgtttttt ccttccgctt tgccgaaata cacgttattc 767521 ggcacatcgt aattggcttt catgtagttt tctacttccg ttacgtcgct ggaatcggca 767581 agcgcgcgct ggctgttgga cttgatattc tgtacagcgt cataaatcgt gaaattgtat 767641 gttcccaagt atttcacaag atagttccgg tcgaatgatc ttgtcagcaa ttcaggacgg 767701 tctgattccg caactgccag gttgatcaag aacacaagaa ttgaagacgc aaaaataatt 767761 cggaacgatt ttttgcttga cgtttcggca ggcttgttta ctttgatcgc caagatgatc 767821 aggatgatcg tatcgataaa gtaaaaggcg tcagtcggtc tcatcagcga aaatgcgctg 767881 tcaccgagtt ggccgccgtt tgttttagcc tgcataatga ccggaattgt aataaaatca 767941 ttgaaaaatc tgtagtacac aatgttggcg tacagtaaaa aagacattaa aaaatgaatc 768001 actataatgg ctgtctgctg taattttttc ttgaacaaga gtccaaagcc aagaaagaac 768061 aagcttgagc taagaggatt cacaaaaagc aatatttttt gtatcgtgtt gtctattcct 768121 aagttgaaat tcaggacata accgacatac gttttgatcc ataacaggac gaccgcaatt 768181 aagaagaagg ccagtcctct ttcttttata aatgttttca ttgttacact ccttttttcc 768241 gatccagttc gagcgaaacg atagaaaaaa cgaacgtatc caatataaca cgaatcagca 768301 gattagaaaa gtgaaaatcg tatgagggag aaagtggcga aaaacgccgt cgaatcaacg 768361 tttcgctttg atattaccaa atgtaaaaca aggtatcttt ctagaaataa aggaataaaa 768421 tggtacattg agaattgtat gataaaatat aaggtataga taaaaagagg tgaaatgatg 768481 gatttttccc atattgtgtc tgaagataaa attaagcgcg ccatcaaaga cggggacttt 768541 caaaacctcc cgggaatggg gaagccgctg ccgaaggatg acgcggcaca cttgccggaa 768601 tcgctgcgca tgggctatcg tattttgaaa aacgcgggaa tggcagagga cgagggcgcg 768661 ctcaaaaaag agcttatgac catcgaccat ttaatcgaaa agtgctatga cgaaaaagaa 768721 cgcgagcaat taatcagaaa aaaatctgaa aagcaattgc tgcttgataa gcttgtcgac 768781 aaaaaaggca tgttttcaaa gccagcatcc gctttttata agaataaagt atatgaccgg 768841 cttggacgaa acagaccttc ttccagctga tttgtcttgt ctgcaggatg gcgattgata 768901 aaagccatcc tttttatgtt ccaagttcta tgtcaaaagg tttatgtttt tccatctatg 768961 ggaaatgatt cataaacgaa aaaagggtga tgggatggaa cgactattag tatggataga 769021 gcatatatct gattggctgt ggggtccgcc gctaatcatc ctgctgacgg ggacgggctt 769081 gtatttcact attttgctga aaggttttca atttcgctat cctttataca ttttcaaaca 769141 gacaatcggc agtgtaggaa aaaagccgaa gggagaaggc acagtcacac cgcttcaggc 769201 attgacctca gccctcagtt caacgatcgg tgcagcgaac attgtcggtg tgcccgccgc 769261 tattatgttt gggggaccag gagcggtttt ttggatgtgg cttattgcct tatttgccat 769321 ggcgattaag ttttctgaaa gtgttcttgc tgttcattac agagaaaaaa atgagcaggg 769381 tgaatacgtc gggggaccga tgtattacat aacaaaaggg ctgcgcatga aatggctcgg 769441 cgtattcttc tctgttgcgc tgattgtgga gctgattccc agcattatgg ttcagggaaa 769501 ttcggtttca gtctcgcttg ccgagacgtt ttctttcaat aaaatatacg caggaatcgg 769561 aattgcattt ttgattgggt tagtggtgat aggaggggta aagcggatcg gaaaagtaac 769621 agagtttgtc gtgcctctta tggcaggggc atacgcaggt gccggtctcc tgattgttct 769681 catgaatcta tcatcagtgc cggcgttttt ctctctcgtt ttttcaaatg cgtttacctc 769741 ttcttcagca gttggagggt tcgcaggtgc tgcgttggcg gaaaccgttc gctggggatt 769801 tgcccgcggg ctgtattcta atgaagccgg gatgggaaca gccccgattg cacatgcggc 769861 agcaatgact gatcatcctg tgcggcaagg gttttggtct gtgatcggca ttgtcattga 769921 caccttaatc atctgtacga ctaccgcttt tatcgtcctt gcatccggtg tatggacagg 769981 gaagaacgcc tcaaatgacc cggcagcact gacaacggcc gcatttcagc actatttcgg 770041 ttctggagga ggatacttcg tttcggtttc cctggtcttc tttgtcgtat caaccattat 770101 ggttgtcatt ttttacggcg taaagcaagc tgaatttctg ttcgggcggc tggcaggaca 770161 tgtgattaaa ttcgtttatt tagcggctat tatcataggt gccgcaggcg gagcaaaagc 770221 catttggggc gtattggact tagcattggt ttttattgtt gtcccgaatg tgattgcgct 770281 cttgttattg agcagaaagg taaaagcgct gtacaccgaa ttctttacat ctgaacagta 770341 ctacctgaaa gatataagaa aaacgaaaca aaagcctgtt tatccaacaa aagaagctaa 770401 aaattcctag tgttttgctt ttgcgccgaa caatgctttg ctttttatga tcaaataaat 770461 gagtaaaggc agcaaaagag aaatcactac attaatgatt ggtttgattc tgttaaagtc 770521 gattagctga tttgtattta aaaaaaacca aaagccgcat acgactgaga acatgccggt 770581 tggtgtatac atggctttcg ggtcgatttt tgagtgtaaa aacgaaaggc cgtataccac 770641 gatatatagg gaacctgcta tcttcaccat aatgaccgga atccaaaaag ccgcgatgat 770701 caggtctgag cgatccagaa aatccgtaat gcggatctgc ctgatgacca tataagcagg 770761 atcaaagaaa gtagatgtca ggttgggacc aaagacagaa attgaagaaa ataacatcac 770821 ggccagcaat aaagcgccca gcagtatcgc gaaaatggtg tattttagcg ggacgctccg 770881 gtttgagaag agaagcggaa ggataatcaa ttcccccatt gtcccaaacg cgtaatagcc 770941 tgattgaagg tatgggatta gaccttcaaa aacaggtgtc aagttttgaa gctcaatttg 771001 tgtggccagc gtaaatggaa ggaacaagac caggatgccg aatggaaata ggaatatctg 771061 cgccattctg gtcaatgttt cttttccctc tctggcaata cagatcgcca caaagataat 771121 aacaccgcca agaacagcca ttggtgttct cgggagaaat aaaatgttaa tcaaattgat 771181 gaaaaaacgt atatcatgag cattgattaa caggaaatac aaagaaaaca gtaaaatgat 771241 aatccggcct gcgattggtg aggaatcgct cagcagctca tagatatttt tatcctgatg 771301 ctttttcatc agcctatgca tgagccagag tgccggaatc acgatgacaa cgccgaggat 771361 gtagctgtgc caggcatttt gttttgctga ttcgatcatg agaatcggag catgctttaa 771421 tccgactgct aacgtataca gagctccgaa aaataatcct tggtatgcag aggtcttgtc 771481 cataaagcac atcctttctg tcatgttcaa aacggaatat atttaaacag gtgccccagc 771541 cgcggaagca ggggattcac tctcatataa atccatagaa aagcacttcc tgcaattagc 771601 aggctgaagg cccattttgt tagattgtta gcggaacgaa aattcttcca ttcatatgcg 771661 tatatggcaa tgcacacaat caatgtctgt acgatatagc tgatcatgct gacgcacctc 771721 cattaatggc tgatcgtttt gtataggaca ccgccctgct caatcgtcac aattgggacg 771781 acgtgaacct ccatatcctt atatacctct tcccattcct ttttcagcag attcttcgtg 771841 gttgccgtgc ttctgatggt cctgtcttga aagccggccg ggtccgcctt tagcttttgc 771901 aaacgatgaa cggtgctgat cacgtccttc tttatggttc tgtttaatgc tttttgaatg 771961 atgtaatact ggtcattttc tctcgtctca taggttgatt ggttttccat aataattcct 772021 ttggctctga tctcgattgt cattgacagc tttccgtttt tttcagcggc atgaaaggat 772081 gcattggact tttgaagctg aatggatgct tgccccattt gattcggcag gtctactatg 772141 aattctggct ggcgggcttg attcagcaac atcagggctg ctgtcatgtg ttcatctttg 772201 aaaatatcca tcaatctgtc ctttttaaag atcgcaagcc cgtcaatttt caaattagat 772261 ttgcctttcc ctccaggttt tgttttagat gcagagatga ccggtgcata cggatcactg 772321 cctatttcta ctagatcaga catgaatctg cttaagaaaa cggggcggct cgttgcgata 772381 atggccagct cccgaatcat ttccgccgga aactgttcaa gctgaacatc ggtatttaaa 772441 atgtcccgcg cttctccccg gctgactaaa atgagcgccg ttaatctgtt ctgcggattt 772501 cgcgttaaaa tatcaaagac tggggcaacg ccgtctctcg ccatatcctc tccaataatg 772561 actgtacgtc tgtgggacgt attgattgtc cgtgacaagg aggtttgcag cttgttgttc 772621 gcttctctga tcgtagtgcc ggaagctgaa tcaacatacc atgtttttga accggcagtt 772681 ccgccgccgc cccctgtttg tccgcctaat tggccgacca agggaatctg catggccact 772741 cgatactgat cttttttctt atcaatggct gagctgacaa caaatgcaat gtcattgatt 772801 tctgtccggt cccagcaccc cgttagaagg atacaaatga gaagcggcaa aacacactta 772861 tatattgttt tcttcatctt ttgggtcctc tcttttcgct cccttctgtc cgttgccgcg 772921 cgaatacgtg cccggccttc tggtcatcgt ccaccaaggc gccctgacaa aaatatcttt 772981 tacttcatct cgtttaaacg gagaaatccc ggataaataa ggaatgccga aagattgcag 773041 cttgcataaa tgaagcacta agataatcgt gccgagcata atgccgaata tcccaaaaat 773101 actcgccaaa aacataagcg ggaaacgaag catcctgatg gagatagcta agttaaaccg 773161 cggaattgta aatgacgcga tccctgttaa cgatacgatg atcaccatgg gggcagacac 773221 aattcccgct tcaacagcgg ctgtcccaat gactagggcc ccgagaatac tgacggtctg 773281 gccgatggtt ttcggcaggc gcactcccgc ctcacggaga gcctcaaaag aaatttccat 773341 aatcaatgct tctatgatgg cggggaaagg aatcggttca cgcgcagagg ccacactgaa 773401 cattaagttt gtcggcatta agtcctggtg gtatgtaata acggcaacat aaatagccgg 773461 caaatataaa gcaacgaata aaaacatata gcgaagccag cggattaagt tagacatcaa 773521 ataacgctca tagtaatctt cactggcctg cataagctgc caaaacgtaa tcgggcctgt 773581 taagacaaag ggcgtattat ctgtgaaaat ggcaaatcgg ccttcgagaa gctgggcggc 773641 gacggtgtcc ggcctttctg tgtattgcag ctgggggaat ggcgagtacg tgtcgtcttc 773701 gataaattct tcaatatatc cgctttctaa gacagcatca atctttatct ttttgattct 773761 tttttttgct ttgtcaataa cctttggatc ggcaagcccg tcaatatagg ccaagacaac 773821 atcggttttg gttttcgtgc cgattttaaa agagatcatt ttaagctgaa acgttttgac 773881 gcgaaagcgc acaagagcgg tattgaccct gaggctttca gtgaagccct ctcttgaccc 773941 tctgatggtc gattctgtta tcggctcttc aatgcttctt ctttgtccgc cttttatatt 774001 taagatcagg ccttttgagt gcccgtcggc aaataaaacc gcgttcccct caatgatgga 774061 tgcagccact ttgctcatac tcgtttctaa tgcaacactt gaaattgata gagtattttg 774121 cagcgcctct tcatgttcat ctatttgatc cgtcaaatgc attaagaaag ggcggagggc 774181 gtgatcctga atatgttcag attttacaat tccttcgata taaacaataa atccgcacag 774241 cccgtttcca aagtcaaatt gtctaaatac gatgtctgag cagccttctg ttaataaggt 774301 cagattttcg aggttttcct tcaaattggg agagatcggt ctgtcctgat tgtcttcaag 774361 ctctttgatg agctgaagcg ctttgtcgcg tttattcata gaggctcacc ctgcttttta 774421 atgtcatatt caataagtgc ttgtgacttt tagggtaacc ttgtctgttt catatattcc 774481 agactaggat gaaagcgcta taaaaaagtg ttgactacct gtatatacag gaatacaata 774541 tgattataag ttgtatatac aagttataaa aacggatacg gaggggttgg catgggggaa 774601 ctgaacaaat cggcacgtca gattgtcgaa gcagtcggcg gtgctgaaaa tattgcagcg 774661 gcaactcatt gtgttacacg tttgcgtttt gctttaatag atgaaagcaa ggttgaccaa 774721 gagatgcttg atcaaattga tgtggtaaag ggatcattct cgacaaacgg acagtttcag 774781 gtcgtaatcg gccagggaac tgtcaataaa gtatatgctg aactggttaa ggaaacgggg 774841 attggcgagt caacaaagga tgaagtgaag aaggcctcag aaaaaaatat gaatcctttg 774901 cagcgtgctg tgaaaacgct tgcagatatt tttattccaa tattgcctgc gattgtcacg 774961 gcgggtcttt taatggggat caataacatt ttaacggcgg aaggcatttt cttcagcaca 775021 aaatcgattg tgcaggttta tccgcagtgg gcggatcttg ctaatatgat taacctgatt 775081 gcaggcacgg cctttacgtt tttgcctgcg ttaatcggat ggtctgccgt caagcggttc 775141 ggcggcaatc cgcttctcgg cattgtgctc ggggttatgc tcgtgcatcc tgatttgctg 775201 aatgcgtggg gatatggcgc ggcagaacaa agcggagaga tcccggtatg gaatctattc 775261 ggcctagagg tgcagaaagt cggctatcag ggccaggtgc tcccaatttt gcttgcttct 775321 tatatgctgg cgaagattga ggtattttta acaaaacgca cacctgaggg catacagctg 775381 ctcgttgtcg caccaattac gcttctctta acaggatttg cctcttttat cattatcggc 775441 ccgattacat ttgcgatcgg taatgtactg acttcagggc ttatctcggt gtttggttct 775501 tttgccgcac tgggcggtct gttatatggc ggtttctact cagcgctcgt gattaccggt 775561 atgcatcaca cgtttcttgc agtcgacctg cagctcatcg gttcaaagct cggcggcacc 775621 tttttatggc cgatgctggc gctttctaat atcgcacaag gttcggcggc tctggccatg 775681 atgtttatcg tgaaggatga gaaacaaaaa ggcctctccc tcacatcagg gatttctgct 775741 tatcttggca ttacagagcc tgccatcttt ggggtgaatc tgcgatacag attcccgttt 775801 atcattgcaa tggtcagctc tggcctggcc ggaatgtata tttcttctca aggtgtgctg 775861 gcaagctccg tcggtgtcgg cggcgtgccg gggattttct caatcatgag ccagtactgg 775921 ggcgcgtttg caatcgggat ggctattgta ttgatcgtgc cgtttgccgg aacatacgcg 775981 tatgcgagat tcaaacataa ataacaagtg gggagcggga cgtgttgaac gttccctttt 776041 cccgttttca atttaaatat ggtggtggaa acagatgaaa acagaacaaa cgccatggtg 776101 gaaaaaagct gtggtttatc aaatttatcc gaaaagcttt aacgatacga caggaaatgg 776161 tgttggcgat ctgaacggca ttattgaaaa gctggattac ttaaaaacgc tacaggtgga 776221 tgtgctttgg ctgacgccga tttatgattc tccccagcat gataatgggt acgatattcg 776281 tgattattac tcgatttatc ctgaatacgg aacgatggag gattttgagc ggctagtgtc 776341 cgaagcacat aaaagagacc tgaaagtcgt catggatctt gttgtcaatc atacgtcaac 776401 agagcacaaa tggtttcgcg aggcgatctc ttcaatagac agcccgtacc gtgattttta 776461 tatatggaaa aaaccgcagg aaaacggttc tgttccgacg aactgggaat cgaaattcgg 776521 cggctcggca tgggagcttg acgaagcatc gggccaatac tatttgcatc tgtttgatgt 776581 gacgcaggct gatttgaatt gggaaaatga agaggtcaga aagcatgtct atgacatgat 776641 gcatttttgg tttgaaaagg gaatagacgg ctttaggctt gatgtcatca acctgatttc 776701 taaagatcag cgctttccga atgcggagga aggcgacggc cgctcttttt acactgacgg 776761 gccgcgggtg cacgaatttc tgcatgaaat gaacgaaaag gtgttttcac attacgacag 776821 catgacggtc ggtgagatgt cttcaacaac cgtagaccac tgcatccggt atacgaatcc 776881 tgacaataaa gaacttgata tgacattcag cttccatcat ctcaaggttg actatcctaa 776941 cggcgaaaaa tgggccttgg cgccgtttga ttttttgaag ctgaaggaga tcctatctga 777001 ctggcaaacg gggatgcacg caggaggggg atggaacgct ctgttctggt gcaatcatga 777061 tcagccgcgc gtcgtatcaa gatatggaga tgatggcgca tatagggtga aatcggcgaa 777121 aatgcttgct acggccattc atatgatgca gggcacgcct tatatttatc agggcgagga 777181 gctggggatg acgaatccga agttcactga cataagctcc tatcgggatg tcgaatcgct 777241 gaacatgtat cacgccttta aggaaaaagg aatggctgat caagatatta cagccatttt 777301 acaggcgaaa tcccgtgaca attccagaac ccccgttcag tgggatgcta cggaaaatgg 777361 tggttttaca acgggcacac catggatacc ggttgcagga aattaccggg aaatcaatgc 777421 tgaagcggcg ctgagggatc agaattcggt gttttaccat tatcaaaaat tgattcagat 777481 tcgcaaaatg tatgacattg tgacagaggg tacgtatgag ataattgcaa aggatgaccc 777541 gaacattttt gcgtatctca gacacggcag caatgaaaag ctgctcgtga tcaataattt 777601 ttacgggaca gaggcggcct ttacactgcc ggactcttta gcgcctgacg aatggaaggc 777661 agaggtgctg ttgacgaacg atgaagcaag ggaagggctt cagaacatga cgcttcgccc 777721 atatgagtcc attgtttatc gtttaacgaa accgtgttaa actaagctgg gtggtccata 777781 atgaaggtga ataaattcat cacaatttat aaagacatcg cacagcaaat tgaaggcggc 777841 cgatggaaag cggaggagat tcttccgtct gaacatgagt tgaccgcaca gtacggtaca 777901 tcaagagaaa cggtccgaaa ggcgcttcat atgctcgcgc aaaacggtta tatccagaaa 777961 atcaggggaa aaggctccgt cgtgctcaat cgtgaaaaaa tgcagtttcc cgtttcgggc 778021 cttgtcagct tcaaggagct cgcgcaaacg cttggcaaag aaacgaaaac aactgtacac 778081 aaattcgggc tggagcctcc gtcagagctg atccaaaaac agctccgggc caatctggat 778141 gacgacatct gggaagtcat caggtctaga aagattgacg gggaacatgt gattttggac 778201 aaggattact ttttcagaaa gcatgtccct cacctgacga aagaaatttg tgaaaactcc 778261 atatatgaat atatagaagg agagctcggt ctttcgatca gttacgccca aaaagaaatt 778321 gtagccgagc cgtgtacgga cgaggacaga gagctgctcg atttacgcgg ctatgaccat 778381 atggtcgtgg tgagaaacta cgtctttttg gaggatacca gtttgtttca atatacggaa 778441 agcagacacc gtctcgacaa attccgattt gttgattttg cgcggcgggg gaaatgagag 778501 aggcgcctgc ctgcggcagc gcgctttttt gtttggtatc aaaattgata ctatccaaca 778561 aaaatgtgcg tacttttact ttttatcata atggctacaa tagagatgag agtaatctaa 778621 aggagaggtg ttttacatgg cagatctaaa gacacaaatt ctggatgcat acaatttcag 778681 gcatgcgact aaggaatttg acccgaataa aaaagtgtca gacagcgatt ttgaatttat 778741 tttagaaaca ggaagactgt ctccgagctc actcggcctt gagccttgga aatttgtcgt 778801 cgtccaaaat ccggaattcc gcgagaagct tcgtgaatac acatggggcg cgcaaaagca 778861 gctgccgacc gcaagccatt tcgtcctgat tcttgcgcgt acagcgaagg atatcaaata 778921 taatgcggac tacatcaaac gtcatttaaa agaagtaaaa caaatgcctc aagacgtgta 778981 cgaaggctat ttaagcaaaa cagaagaatt ccagaaaaac gatttgcatt tgcttgaaag 779041 tgacagaaca ttgtttgact gggcatcaaa acaaacctat atcgcgcttg gcaacatgat 779101 gactgccgct gcgcaaatcg gtgttgattc ctgcccgatc gaaggcttcc agtacgatca 779161 cattcaccgt attcttgaag aagaaggcct tctggaaaac ggaagcttcg atatttctgt 779221 gatggtggca ttcggctacc gagtgagaga ccctcgtccg aaaacaagat ctgctgttga 779281 agatgttgtg aagtgggttt aaaagaagaa agctgctcgc atagcgagca gctctttttt 779341 atgcctgatt cgctctattc tgttttctcc tctgatgtaa gtacattgcc gttccgagtg 779401 cgctgatcag aaatccggcc aacaggatcg agtacatgga tgtggctgtg tccggaagca 779461 ggccgccagc cggaccgtct gttcctgatc cgcccgaacc gtttccacca gagccgttag 779521 tcggttgagt gccgggaggc gtatcatttc ctccgtttcc gtcagttggc tgttttccgc 779581 ctggtttgtc ggagcctccg ccatgattgc cgtcatcacc gcctgtcggt tgatctgacg 779641 ggaatgccgg cggtttgttg tttgaaccgg aatttaagat cgtgtattcg ctgaagtggt 779701 ttgtatatcc tgtcaccata tcatcatcga ctgatccgtg acctgtcttt gtgaaagctt 779761 tcttttttct atcgacgtga taaatggcag ggttatgggc ttcttcaata tcaaacatgc 779821 gaagcgaaag ctgtacgggc tccttgaatg attttatttc ttttcctttt tgcttcactg 779881 taaagtcata tacatctgac agtgacacat ccaattctcc cgtagacttg attccgattg 779941 cagtgtctgc ggttttaagg ttcgccattg gcatcttcat gctgtaccag tagttgaaca 780001 tcgtcaatga aggatctgac tctctttctt tcaaaagttt gacctgatct tttttcactt 780061 taagattgat aggcttctct tgagatcctt catgtattcc ataatagaca aatggcgtgt 780121 tggcattttt agcataaatc gcaaatttgt cttcatcaag tgtccagctg ccgtccttct 780181 gctttgtcgg caggaatact tctttgattc gtccttcaac tttaggagag accttgtttc 780241 ctagtttttt cagctgttcg gtgaaaatct cataatcaac gtagccaagg tcttcaccat 780301 gggaggcttc tgtaaagaca gaatatccgt ctcctccggc accgacaaaa ttatttgttg 780361 ccacgcggta ggtatcatcc gtatttatag caactttgtc tccgttaggc gattcaattt 780421 tcacttctaa cacacggtgt ccaggtttgt tgtttaatgt aaaggtatat tcgattccgg 780481 ccacctgagg gaaagcgccg ccgccatttt ccacattgct taggccttgt tcaagggctt 780541 ctttaatttg ttttccggtt aaatcggcca cgtaaagcgt attgccgaac ggcatcacgt 780601 tgagcacctc gccgagtgtg atatcacctt tgtcaatgcc tgctctgatg ccgccgccat 780661 ttgttatcgc tattctggcg ccggctgctt ctttcgcttt tgccagcata ccgtccgcga 780721 tgaagtttcc gagattcgtt tctttcgtgc gcacatgctc acgctggccg tcaagcgcca 780781 catccgtgta gccgactttt tcatttttca cgtcctctaa ttcatttttg aactgatcga 780841 gctcttgttt tgcttctggg ttttcttctg tatgttcatc aattggcagc acgctcagat 780901 ttgatttatc tgtttgcaca acgccttttt catcaaacgc gacatcaacg cgccccaaga 780961 attggccgta ttcttttgcc tgcgccacga tcgtcggttc ttcgttgttc acgacctcca 781021 ttttgtctac gagggtgtga gtgtgtccgc cgatgatcaa atcaatgcct tttacttttt 781081 tggctagctc aagatcccgg ttatgtccga tgtgggttaa agcaataatt ttatttacct 781141 tttcttcttc ttgaatcgct ttgacggtgt tttgtgctgt ttcaaaggca tcattgaata 781201 cgatgctttt gcccgggctt gatgtggtgg ctgtatcttc tgttgtcagg ccgaatacgg 781261 cgactttctc cccgtcaacg tctaacagaa tgtaagggtg aatgccggcc tctttctttt 781321 cacctgccgt aaaggtttgc ggctttttga caaatgattt cagcttgggc tcatttgaca 781381 catctacgtt tgcactgaca atcggaaatt ccggcgcttc aaagtgatag cggttcgccg 781441 gatcaacggt tgcgctgttt ccgcttagaa aatcagaaag caccgtcggg cctttgtcaa 781501 attcatggtt tccgaaggtc atggcgtcat agcccatcat gttcatcatt ttcagatcgg 781561 ccaaaccgtt ccatttagta aaatacagat cgccggaaaa cacatctccc gcatcaagga 781621 gaatattgtg atttgtttcg ctgcgtactt cgttgatttt cgtcattcgt ctcgctgcat 781681 catcgagatg ggcgtgcgta tcattggtgt gcatgacggt cagatcccac agtccgtctt 781741 taggaggatc tggatttgaa tcatcatcga attgcagctt atacacacca tagccttcat 781801 tcgcagactt gcctacataa gcgacatcgt ctgctttatc ggcaaatggc ttggccaaaa 781861 gcgaggattc aaacgtcaga ttcgtgccgg aaacaggcgc gattgaccag ttgttgtctg 781921 cttttggatt gactgttttt tgttcaataa tgtaatccat cagcacctgc ctattttcaa 781981 ctgcagagcc gtggacaatt ttatcgctcg tcagatgagg gaacccgccg cctccggacg 782041 cacgatagtt attggtgact acgagaaatt cctggcttgg gctgatcggc ttgccttcat 782101 aggaaagatt gatgatacgg gatgaatccg cattgatcac ttttccgttc tcattgtatt 782161 tagccggttt tgtcacatcg acctgatatg tgacaccgtc aatcacgtca aaattatagg 782221 agcggaaatt ctcgttcagc aaggcctggt cgccgccttt agctggatca atttgattga 782281 attggcctgc tgacatctcc agccagtcct tgacctcgct gcctgtcagc ttgacgattt 782341 gaacagtatt atcgtaaaga tacaagtcac cgacattttt aatcgcaaga tctccggctg 782401 gaatgtttgt atagtaattg gctccgtttc tgccgcctgc tttaaacggc gctccagcgg 782461 ataaaatcgg caggttcttg tactcggtat ccttcatttc tttttcagcg taccactttt 782521 gcgcgtcagt cacgatctga atggaaggat catctttgac ctgtgcaaag aagctgttaa 782581 tatctgcttc ggttttgccg actggctttc ggacatactc cagtgtgttt tggtgtgttt 782641 gctgaatggt gtttgtaacg gtttcgtttc ttgatgtgac gttgccagca atagattcaa 782701 tacttccttt ggaatctgct accttccatg agccgtccgc cttttcaagc ttgaggtcaa 782761 tcacgcctaa atatttgccc cagctgcttg gcatgacgac aggaatgccg ttaattgttc 782821 ccttttccac attgaactga gcaacacccg catactcggc ggaaggaaag agtccgtgct 782881 gatggcccga gataatcgcg tcaatgcctt tcgttttggt ggcaaggtca aacacggcgt 782941 tttctgcgcc tgatgattgc gcctgctttt caatgccggt gtgggcgagg gcaataatga 783001 catctgcgcc ttccgccttc attttcggga tcgtttcatt ggcggattct acgatatcct 783061 gcacctgaac ttgcccctcg agattctttt tgtcccatgt catgatttgc ggcgggacaa 783121 agcctatgta gccgactttt actttctgct cattaccgtt ttcatcaatg agggtttttt 783181 cattaatcac atacggcgta taacggtttt cgccgctagt tgttttgacg ttggcattta 783241 caatcgggaa atcggctcct ttgattgtgc cgtcgagaaa gtcgagcccg tagttgaatt 783301 catgattgcc aagcgttccg gcgtcgtatt tcagcgcatt catgacgctg ataatcggat 783361 gggttttcgt gccggagata atgtcgtctt tttgatattt caccgcgtat tcacccagcg 783421 gattcccttg aatcaagtcg ccgttatcca caagcagggt gttagggttt tgctcgcggt 783481 gcttttggat caattgcgct gttctcgcca gaccgaaatc cgccgtttct ttgtcgctgt 783541 agtaatcgta atccatcatg ttggcatgaa tatcagtcgt agccaaaata ctcagatgca 783601 cctgaggagc cgcgctttct tctgcatgaa tgggtggtgt tgggaggatt aggctaagta 783661 tcataattgg gggcaaaaga atacggagaa tgttttcgac gtgtgttcgt cttttctgta 783721 ttctcaccag ttctccacct ttcaacgaaa tttgtgttac agctcctatt gtaagaatat 783781 tttgtaacta tttgtaggtg tttctttatg attattgtaa aagggagaaa aatgagtatt 783841 atgtagcagt atcaaacgac aaatactggg catttatgct tatcgtttgt cacaatcgcg 783901 gaatgtttat tttagtgtgg ctggggtaga gtgttttatg tagacatata aagcgggagg 783961 ttatgaatca tggggaaaaa aattgcagtt gttttaacat attattttga ggacagcgag 784021 tacactgagc ctgcgaaagc ctttaaagaa gcgggacatg aactgactgt catcgaaaaa 784081 gaaaaaggaa aaacagtaaa aggcaagcag ggaacagcgg aagtgacggt tgacgcgtcc 784141 attgacgacg taaattcttc agactttgat gcgcttttga ttcctggagg attttcacca 784201 gaccagcttc gcgctgacga tcgtttcgtc caatttacaa aagcgtttat gactgacaaa 784261 aagccggtat ttgccatttg ccacggcccg cagcttttaa tcaatgcgaa agcgctcgac 784321 ggccgaaaag cgacgggcta tacgtccatt cgtgttgaca tggaaaacgc cggtgccgac 784381 gttgtggaca aggaagtggt tgtttgccag gatcaattgg tcactagccg cacaccggac 784441 gatataccgg catttaaccg cgagtcattg gcattgcttg agaaataaga aaaaacggac 784501 gctcttgggc gtccgttttt ttgttgctta ggcttgagca cctgtcagtt tcttgtacct 784561 gtaatacaag aaagcagctg cagccgttcc gatgaccgca atgccgaagt cgaatatgaa 784621 aatatgggcg atgccccccg cttttgcgat aagccctgtt gcaatcggca gcagaatcga 784681 tgcaagactt gaagcagtcg ctacaattcc ggtaacggtt ccttttcgct tccagaaaag 784741 ctctgtcatt aacgtaatgg taatttgaaa cacacccgca gttgaaaagc ctaagaaaaa 784801 ggcagtgatg tccagcacaa ctgggatatg aacggtcagc atgactgcga gcgtacataa 784861 agtaataata ggatataaga gcgttatgaa gacaggtttg acccatctat tcagcaaaac 784921 ggctaataat aaaacagatg ccagagatcc tatactataa tagctcagca attgtacaga 784981 tgctgattca gctaaaccgg ctgccttttg cgcgtagctc gggagccaga tttgagaaac 785041 cgtaaataaa gccgtggatg taaaaccgat gataatcagt gcggtgcctt ccttctgaaa 785101 aacgggttca gacaagaaaa cgggagattc ctgttggccg ctattagttg gtttcttatg 785161 ttttttagga aacgaaagcg ttgataaata aataatattc aggagataga ccgctgccgg 785221 cagataaaaa gcaaatccgt aaaacatgct gtggtctgct aaaaatgtga tcaaaagcgg 785281 caaaagtgcg gcccccacag acataaaggc tttaaccaag acatttgccg aaccggaagc 785341 agacggaaag agctcggtta gggccggata tgttccggca tccatggctg aattagcgac 785401 tccggctaat aaagcgaaca caaacgccag ctcatagctc ggtgataaag gaataccgac 785461 taaaaagacg gccataattc ccgcagaagc gacaacaagc ggctttctgc cgattttatc 785521 tgatagaacg ccggaaatgc cgtatgtcag cagtttgcca aacccgatag cggcaatgac 785581 ataactgatg ccggtcggat cggtattcca ctgttttgtt aatgaagaca tattggatgc 785641 gagaatgatg ttgaccatcc ccagaaagaa gtagttgata tacattccgg atgctgtttt 785701 gatagatgtc gtttgcatgc ttgtactcct tcaaatctta ttcgaacact ttgctgtttt 785761 ggtttgggga aatgataaaa aagactcgcc gagtttccgg ccagtctcca ttatttacga 785821 agcgaggcta attcttgagc aatcgcctgc atttcacttg ggctgaatga ttcttttttc 785881 atcaccattc tgtgaaggta cgtgaggtct tcaatcttct catcactgaa atcctccgct 785941 ttgattacgc cgacgttcag catgttcagc ttttgggaaa tctcttcaat catttgagtt 786001 aatgtttctg tatttgggct ggacaaaggg ttccatcctt tctatgcgca atataggtat 786061 gttttattct aacagaattc catcagaaaa aaaccctatt ctaaaagcag gctgttcatt 786121 ccaaaaaagt gaagacatca gttgaaaaga aaatgaacat cctactaaga tattcatgaa 786181 ggtttctttt tagagaaata ggggcaaaga atagggaggt tgcacatcat gataagcgtg 786241 ttatttgttt gtttaggtaa catttgccgg tctccgatgg cggaagcgat ttttagggac 786301 ctggcagcca aaaaaggatt agaggggaaa atcaaggcgg actcagccgg tattggcggc 786361 tggcacatcg gcaacccccc gcatgaggga acgcaggaga tattgcgcag agaaggaatc 786421 agctttgatg gcatgctggc gcgtcaagtc agcgaacagg atctggacga ttttgattac 786481 atcattgcaa tggatgcaga aaatatcgga agtctcagaa gcatggcggg ttttaaaaac 786541 acctcgcata tcaaaaggct cttggactat gttgaagatt cagatctggc tgacgtaccc 786601 gatccttact acacagggaa ctttgaagag gtctgccaat taatcaaaac gggctgtgag 786661 cagttgcttg catccattca aaaagaaaaa caattgtgag tgaaaggaga atttgcatga 786721 acaacgaacg tttaatgctg aaagggatat ttctcggagc tgcggcaggc gcggcgttat 786781 cactgctcca taagccgaca agacaggcgt gcgggatgag atggctgaca tgcaagcata 786841 aactttcact gtacaaaagc aacccagagc tgttaaaaaa cactgtcatc acaaaagtgg 786901 atgaggccaa aaagctcgcc cgaacgcttt caaaggaagt cgactttgtg aaccagcagg 786961 tgaaagagct gaagaaaaca acgccgcaag tgatggaact cgtgcaagaa acgaaagagc 787021 atttttcaaa aaaatgatca aacatgcgag gtgagacgac atgagttttt tgaaagagct 787081 tttcagcaga tacacccttc atgaaggaca aagtaaatca gcggagctgg cgtatttttt 787141 tctattgtca ctgtttccgt ttttgatttt tatgctgacg ctcaccgcgt atcttccgct 787201 ttctaccgat gatgttttag gagtcataga acaatatgct cccgccagtg cgatgtcact 787261 cgttgaatcc attacccatc aaaccttaaa taatcgaaat ggcggtttgc tgtcattcgg 787321 gattatcgcc gcattatggt ctgcgtctaa tggaatgaat gcgatcgtcc ggtcgctgaa 787381 ccacgcgtat gatgtggaag aaaaccgctc ttttatcatt gttcgtctaa cctcgatttt 787441 tttgacgatt gccatggtat ttacgatttt agtggctttg cttctgccgg tatttggccg 787501 ggagattgga aggctcgctt ctgactttgt cggcgcgtcg gatctgtttt tatccgtctg 787561 ggccgccatt cgctggggtg tcagcccgct tgtgcttttg attgtttttt ccgcgctgta 787621 tgtgattgcg ccgaacaaaa agctgtctct ccggtttgtc atgccgggtg cggtctttgc 787681 gactatcggc tggatcattg tcagcacatt gttttcattt tacgtcagca cgtttgcgaa 787741 ctatagcgcc acttacggga gcatcggggg aatcatcgtt ctgatgattt ggttttactt 787801 gagcggcatt ttaattatcc taggcggaga aatcaacgct cttttacata aacgtaaaaa 787861 gcttcctgat gaaaatccct accattagcg caccctataa acgaacttcg gttcaaaaag 787921 aagtcggggg gatatcgtga tgaccaagca tacgaaaaaa ggcggaagcc ataacaaaca 787981 aaactcgaaa agcaaatcga gccataaaac aagcggaagc gccaacggac aaaacggcta 788041 ccattagcat aaaagcctcc tgacatgatg tcgggaggct ttttgattaa gaagatgaag 788101 aataggtttc agccggtgac cagcttttcg gtttgcccag cacaagggcc agccacacag 788161 agctaagcgt gagagtaatg aagtagaaca agtttgcgct ttcaaatgtc tgcatatacc 788221 agccgccggc aactgggccg aggatgctac cgagactgaa tgtaatgccg caaagcaggt 788281 ttcccgccgg caggaggtga ggcggaagaa ggtctgtcat atagctgatg ccaagtgtaa 788341 aggttgatcc gactgccatt cctgcaataa aaaagcagcc gccgatcacg tagggcgaag 788401 gaaatacacc ggcgatgaaa aagcaaagag ccccagtcag taaaatcacc agcagcacat 788461 tccgcctgcc gtatttatcg ctgaggatgc cgagcggaaa ctgaaagata atgcttccaa 788521 tcgcaaatgc gggaaggatg atcgctactg cgtctactga tatccccaaa cggagcgcgt 788581 acaccggaaa gcttccgttc agcgccgttt ccagaaagcc atagccaaat gtaggcataa 788641 aggcaaccca cccaaacagc atggcctgat aaaatcgcct gaaactattg tctgatttgg 788701 tttcatgagg actggtttcc gggtatgcat tttgtagaaa gaaaacaaaa agccacgcaa 788761 acagactgat gcagccggac acgataaaag gaagcgacgg actcagcttg acaagcggca 788821 ccatgaacgg gcctgcggca aagccaaggc caaaggaaag cccataaata gacaggtttc 788881 ttccgcgatt ttgttttgat gacatggagg tcacccacgt ttgcgtagaa aagtgaagca 788941 tgtggtcgcc gattccaatg aacaggcgaa gcaggaacca gacccaaact gactgaagcc 789001 aaataaatcc gaataagctt aaaatgacaa tgcttccgcc catgacgatc agcggcttga 789061 acccgagctt tctgagcggt gcttccataa acggcgaagc caaaagcaca ccgatataca 789121 gcccggtcgc gtgcaggccg ttgatagcag cggattctcc atttgtttca aaaatgattg 789181 aaatgacagg cagcagcatg ccttgtgaaa acccggaaat ggaaacgagc aagacaagga 789241 taaagaaatg aaatcgtgac atcgtgtcag ttctccttat atggaatcta tgttgatcgt 789301 acaacgtttt ccaaaagcag gcaacctgaa aaaagcctat atcacgctat acatttgccc 789361 tcgtgtaatc atgaaggttt ttgtgaagaa taaaaataaa acaagtcata aaaaaggagc 789421 tatttcacca tgaatcgtat cttttttatt ttagtggcgg ccggtgttcc gctttctgtg 789481 attggcagtt tgatgcattg gccttccgcg gttctatttg cagtttattg cgtgacgatt 789541 atcgcgcttg caagctatat ggggagggcg acagaatcac tgtccatcat tgcaggaccg 789601 cgtatcggcg gtttgttgaa tgcaaccttc gggaatgcgg tggagctgat tatttccctt 789661 tttgcattaa aagaaggcct gacaggaatc gtgcttgcct ctttaaccgg ttcagtgctg 789721 gggaacctgt tgctggtagc gggcctatcg ttttttgtcg gcggtttaaa atataagcgg 789781 caggaattta atatccatga tgcccgccat aactccgggc ttctgatttt tgccatcatt 789841 gtcgcctttg tgattccgga ggtattctct gttggtatgg gaaacgccag caagctcaat 789901 ttaagcatcg gcatcagcat cattatgatt ctgttatatg tggcggcgct gtactttaaa 789961 cttgtcacgc atcggggcgt ttatcagccg aataatgccg ctcagactga agaagaggaa 790021 gagccagaat ggtcagggaa ggttgcgacg attgtcttgt ttgcggcaac gattgtggtt 790081 gcatacatat ccgaaaacct ggtccatacc tttcactcgg tggctgaaca gttcgggtgg 790141 agcgagctgt ttattggggt catcatcgtg gcgattgtag gaaatgcggc ggagcatgcg 790201 tcagcgatta ttatggcctt caaaaataaa atggacattg ctgttgaaat tgcagtaggc 790261 tctacgctgc agatcgctat gtttgtcgca ccggttctcg tcatctgttc tatctttttt 790321 ccgacaagca tgccgcttgt atttacattg cctgagctcg tcgcgatggt atcagcggtt 790381 ctcttgatga tcgcgatttc gaatgacggg gattccaact ggtttgaagg ggcgacactg 790441 cttgctgcat atgtcattat ggcgatcggc tttttccttc tttaacctga aaaaatgatg 790501 gataacaaca aagcgggatg aaaagactaa gggaaaatgc catagaaaga gtgatatgat 790561 gaaaaagcta tttcattcca cacttattgt gttgttattc tttagttttt tcggcgttca 790621 gcccatccac gcgaaaaagc agtttaaggt tcctaattct gtcgcaagca tttcaaagga 790681 aaacacgtat ccgaatgctt cacaggatca gccaatgctt cagccgagca agctggcaaa 790741 ggaattgctc gatcattctg aggtaaagat tgaaaatccg catctcatca aaatgctgaa 790801 tgaatccaac atatccggca caccgcttgc agtagggtac cgggcgacaa tatttctcgg 790861 gaaatgggcg ctcggctatg aatcaaatga aacagtcgca aactgggaat ataaaaaaat 790921 caatacaaac cgtgcggata accgcggcgg gaaagaaacg gctgaaatgc attatgccca 790981 ggaacagcag tacagagtga agggcggctt gacagctaaa gttccaaatg ctgaagatgt 791041 caaaagcatg atgatgcaaa aagcaatgaa gaaaacgaac ctcccgcttg catttgagac 791101 ggtcatcggg gctggcacaa aacgggatca gatttataaa gtcgctccta aaaaaatcgg 791161 ttatctacat gcatatgcac cggctgtgaa tgaaaaagga aaagtgactt acggagaagt 791221 gtacttagtg ctgaaaggaa ataaacgaaa actcgtcgtg aaaaatgtca cgtcacaggg 791281 aatcggcgcg tggattccgg ttcaagatca tgtcacgttt ggctttcagc tttcctcact 791341 gccaagataa ataaaaaact gattccaact cggaatcagt ttttttgttt attgggttct 791401 ctcgattcgg accgcttcct caagcatttg cacattgttt tggtagagct ggcgaacgag 791461 aacccgtctt actgcaaggc tggcactgaa ataatcatca tctttcacca tgcctttaac 791521 cgtaaattcg acgccgcgat tgattttatt caatgcggtg atgccgtgga tttgaaacgg 791581 ttctgtcgga ttgccgaatt catcccgctt caatgaatca cgaagctctt cattcagcat 791641 gtcacatgcc tcttccaaca cgctgtacac gcggtccgga tcttctttaa agctgataag 791701 aaaggattcg gtaatccgca taaaatcaat attatagttc tctatttgtc tgacctcgcc 791761 gttgctgatg gtgagcagct tcccgctcca ttcccggatt tgcagcgagc ggaggccgat 791821 ttcctccact gtcccgttga acaagttgtt gacggtgaca taatcgcctt tgtgcagctg 791881 gcgttcatat attaagaata caccagccag cacatctttg atcagcgatt gggcgccaaa 791941 accgatcacg atacctgcta cgcccgcccc ggccaatatc ttgccgaaat catgcacaaa 792001 taaagaaata acgtaaaaga taaaaccaat tgttgccgta tactgggtga cagaacggac 792061 aaggctttca atcgtttttt cctttttttc ttcaataaag tccgtccgtt taaaaaatag 792121 ctgtaccagc cggttgatga taaagacacc gatccaaagg ataacggcaa cgaggagaat 792181 atcgacgatt ttattttgaa aaatctccgt aagtgtttct ttcatccgca tctaactcct 792241 ggcttgacgt tttgtgaagt ctgtatcctg ataataactg tttttgacaa gaacattcgg 792301 tccgaggcac cggacattcg ggcagtggca actcagttct ttcgcaagct tggtctctct 792361 ccacttttca taggcggaag ggaggctgtc cgtctgaatg ttgccaagcg gcggggtatc 792421 accgaaatcg gtcacgataa tgtttccgtc gaaaatgttc acattcaggc gggatcggcc 792481 gtcagggtca tttcgcactg tgacgttttt cgccgcgcga agccggcgaa gcagcttttg 792541 gtcgtcttcg tccggactgc aggcataaaa cggcagcgtt ccgaacagca tccacgtatt 792601 ttcatcacga atatccagca agcggtgaat ggcctgtctc atctctttca ggctgaggga 792661 ttcaagagcg cttgcgaaat cgcttggata cattgggtgg acctcgtgac gctgacattt 792721 catatcttct gtgatttggc ggtgaatatg ctcaatatgc ggaagtgttc gtttgttcag 792781 catcgtttcc gcagatacca ttactccggc atccacgagc gtgcggctgt tttcgatcat 792841 tttttcaaaa tagcgcgcgc gctgttcgaa ggtcggtttt ctgtccatca tggcaaagcc 792901 gatttcagca aaatcttcaa ctgttcccca gttatgtgaa atatgtagca catcgagata 792961 cggaatgatc cattcgtacc gctcgatgtc gagggtcaga tttgaattaa tttgtgtccg 793021 cacaccccgt tcatgggcat atttcaataa aggaacaaca tattctttta ctgatttcaa 793081 cgaaagcatc ggctctccgc ctgtgatgct gatggatctg aggcgcggga tttcctccag 793141 ccgttttaac agaagatcta ttggcagagc attcgggtct ttaggctgca atgtatagcc 793201 tacagcacaa tgctcgcatc tcatattgca cagtgtcgtt gttgtgaatt caacgtttgt 793261 cagctgcatg tctccgtatt ggtcaacatc catataggct tcccaagggt caaactcggg 793321 cgtaatcgga cgcagcttcg tgttttgtgt catgactatc taactccttt ataaatgggc 793381 atactaacgc tgccaacagt taattttaga cctgatttgc caagatcgca agtagcgcgg 793441 cgattgaaaa acggcaaaaa atgagctacc ataataaaaa atgaatggag gaacagaatg 793501 gggaacgccg taaacaataa agatcagcag attgattatt taaagaacag acttgacatg 793561 tttatgaacg tcatcgattc attagaccct gaagcaaccg acgttgaaga tatagacagg 793621 cttatcagca tgcttgatga cctggaagcc aaatacgaac gttttaaaaa agattgggaa 793681 taaaaccgcg tgcccgccgc ggttttttta ttggcataaa gcaacagtat aaaacaaagt 793741 ctctatctgt aaaataagaa aaaatgcaga aggagcgctg gccatgaagt ggatgtgttc 793801 aatatgctgc gccgccgtat tgcttgccgg aggtgcagca caggcggaag cggtgccgaa 793861 tgagccgatt aattggggct ttaaacgaag tgtcaatcat cagccgccag atgccgggaa 793921 gcagctgaac agtttaattg aaaaatatga cgcgttttat ttagggaata caaaggaaaa 793981 aacgatttac ttaacgtttg ataacggata tgaaaatggc tatacgccaa aagtgcttga 794041 tgtcttaaaa aaacatcgcg taacaggaac gttttttgtc accgggcatt tcgtaaagga 794101 ccagcctcag ctgatcaaac gaatgtcaga tgagggccat attatcggca atcattcctt 794161 tcaccatccg gatttaacga caaaaacagc tgatcagatt caggatgaac ttgattcagt 794221 caacgaagag gtttataaaa ttacgggaaa gcaggacaac ctgtatttgc gtccgccgcg 794281 cggcgtgttc agtgagtacg tactgaaaga aacgaaacgc ctcggctatc aaaccgtttt 794341 ctggtcggtc gcttttgttg attggaaaat caacaaccaa aagggaaaga aatatgccta 794401 cgatcatatg atcaagcagg cgcacccggg agccatttac ctgcttcaca ccgtatcgag 794461 ggacaatgca gaagcgctgg atgacgcgat tacagatctg aaaaaacagg gctacacttt 794521 taaaagcatt gatgatctga tgtttgagaa agaaatgagg ctgccgtctt tgtaaaagag 794581 aaagacctct ccttaaacgg agaggctttt ctttatttta tacatttaat cagtgcggcc 794641 cagtccagat ccccgaagcc tttctcaatc ccgctttcaa aatggctctt ggccagctcg 794701 gcaagaggaa gatttgcaga aacccgtttt gcggcggcga gtgccaggtt ggtatccttc 794761 agccctaaag acattttgaa gccggccggc tcaaatttct gctcggccat aatggttccg 794821 taattttgat agactggaga accaaagagc gcgctggcga tttctaaaaa ttgtttttgt 794881 tctaagccgt atttctccat cattaaaaag gattcagata acgcctccag catggacaca 794941 agcaagaaat taatgctgat tttggctgca tttgccgtct tgctttcttc gccgacgtca 795001 aatatctgct ggctcaggct gtcgagcaga ggcttggcag cttgctttgc ttccgccggt 795061 ccggctgtta tgatacggag cgcggctttg gctgcggcat ccggtctgcc aaggacagga 795121 gcggcgagaa aaaattgtcc tttctctgca tgagccgctg cgagcttttc tgagaactca 795181 acactgattg tgctcatcga gatgtgtatg ccgttctctg ctaatccttc aagcagcccg 795241 tcttctccga atgtcacggt gctgacagaa tcatcatctg caagcattgt gatgacaata 795301 tcagcggact ttgccgccag ccgcggcgta tcagctgcct gtgcgccttc tgtgacaagg 795361 tcttctgtct tttgtttcgt ccggttatag acagtcaatt cgtagcctgc ttgaagaaca 795421 tttcgggcaa tgggctgtcc catattgccg agtccgatga cagcaatttt caatctaatc 795481 actccctgaa tattttttcc attataaaca atatgaacag aatatgcata gcgatcggct 795541 tacaacaaaa aagaacagct gctcgctgtc ctcatttaaa aatattgaac catcctttat 795601 gtacaaacca aatcagcatt ccaatcacaa gcgcggccat caggccaagt acagcgaaat 795661 atccgtattt ccaatgcagc tccggcataa agtcgaagtt cataccgtat acaccggcaa 795721 taaaggtgag cgggatgaaa atggttgata cgatcgtcag tgtcatcata atcgcattca 795781 tccggtttga gtttagcgtc acgtagctgt cacgcaagtc ggacgtcatg tcacggttgg 795841 attccacaat ttcagacaac tttaacaaat gatcatatat gtcgctgaaa taggctttcg 795901 tttcccgctg ctctttcaca tggtcaaggc ttaaaatccg gtagagcaaa tcacgcatcg 795961 ggataatcgt ccgtctcaaa tgcaataggt ctgttctgag atcaaacacc tcgttcatca 796021 gcgttccata cgttttgtgg ggacggcttt cttcaatttc attcagccgg tcttcaattt 796081 tatacacgag aggaaaatat tcatcaacaa gctgatccat gatcatataa gaaatatgcc 796141 cgggcccttt tttcaatatg tccggtgaag catacaaacg ctcccggact ttagcgatac 796201 cgggcgtttc gtgtaaatga aaggtgacga caaatttttc gccttgaaag atatcgactt 796261 cctccgtctc aagtgtttcc ttattcagcg catgaatcac gtaaaaacga tagccgtcat 796321 aatggtcaag ctttggccgc tgcatatgct ggaagcaatc ctcaatggca agcgggtgaa 796381 aatgaaaaaa atctctcaat aacgccgttt ccgtatcctc cgggccgtaa aaatcaaccc 796441 agtaccatgc aatatcaggc tgttccactc gttcgatcgg tatatttttc agcagctgat 796501 gctctgttgt gattgcggta atgttgatca taaacaaccc tccacctgcc attatatcat 796561 gcggtcttta tgagaaaagt atacggtact ctctgcctaa ttccagcggc atgttatact 796621 gaacaaaaac ggaaaaaagg gtggatctca tgtggaagga aaaagtatct gtcacgcctc 796681 cgtatcattt tgaccgcgtg ctggacaggc tgtctttaga ccccctcaat gctgttgatc 796741 gagaggcgag ggaagtccgt gtgccaatca gaaatcaagc gggggacgta tgtattgtaa 796801 aggtacaggc gttaggccat gcgggcgagc ctgagttcct cgtcagcggg gaaacggatc 796861 agggagaaat gatgaaggaa atcaagcgga tttttcaatg ggaaaatcat ttgcagcacg 796921 ttctggatca tttttcaaaa acgagcctgt ccgccatttt tgaagagcat gccgggacgc 796981 cgcttgttct ggactacagc gtgtacaact gcatgatgaa atgcattatc caccagcagc 797041 ttaatctttc cttcgcttac acgctaacag aacggtttgt tcatgcgttt ggcgagcaga 797101 aggatggcgt gtggtgctat ccaaagccgg aaacgattgc ggaactcgat tatcaggatc 797161 tgcgtgatct gcaattcagc atgagaaaag cggaatacac cattgataca tcaaggatga 797221 tcgcagaagg cacactcagc ttgtcagagc tgccgcatat ggcggatgaa gacattatga 797281 agaaactgat caaaatcagg ggtatcggcc cgtggaccgt gcaaaacgtc ctcatgttcg 797341 gacttggccg tcccaattta ttcccgcttg ccgatatcgg cctccagaat gccatcaaac 797401 gccactttca gctggacgat aagccggcaa aggatgtcat gctggcgatg agcaaggagt 797461 gggagcctta tttaagctat gcgtctttgt atttgtggag gagtatagaa taattcgtct 797521 gacaatgaag gaaatcctgc aaacgtgtta tactagaaag atgtgaaaaa accatttcac 797581 tttctgccat ccgcagaaag cttcatatag aaacggagag aacaacgtga accaacaaaa 797641 gaaacaggcg cccgtcgaac tgaaggtcgg acaaactttt ccgctgacga ttaagcgtct 797701 cggcattaac ggagaaggtg ttggctattt taagaaaaaa gtcgtcttcg tgcccggcgc 797761 gcttcctggc gaagaagttg ttgtgcaggc cacaaaggtc cagccgaagt tttcggaggg 797821 ccgcattaag aaaatccgca aggcatctga gcaccgggtg gcaccgcctt gccctgttta 797881 tgaacaatgc ggcggctgtc agcttcagca ccttgcatac agccagcagc ttcgggaaaa 797941 acgtgatatc gtcattcagt ctcttgaacg ccatacgaag tttaaagttg aaaacatgga 798001 aatcaaagaa acgattggca tggacaaccc gtggaattac cgcaataaaa gccaattcca 798061 gatcgggcgc tcgcaaagcg gcagcatcat cgccggctta tacggccttg attctcatga 798121 tatcgtgccg attaaagact gtatcgttca gcatccggca acgaacaaaa caacaggcat 798181 cgtccgccgc attttagagg acttcaatgt gtctgtttat aatgaaagaa aacgaaaagg 798241 cgacgttcgc acgatcgtga cgagagtcgg ctttgaaaca ggcgaagtgc aggtcgtgct 798301 tgtaaccgca aaagaaacgc ttccgcacaa ggaagaaatc gtcaaagcga ttcaaaagcg 798361 attgccagag gtcaaatcca ttattcagaa tgtaaacggg gcgaaaacct cagtgatttt 798421 tggtgagaaa acaaaacagc tcgccggaaa aacagtgatt caagaagtgc tcggcgacgt 798481 atcttttgaa ttgagcgccc gcgctttctt ccagctcaat ccggaacaga ccgtcaagct 798541 gtatgatgaa gtgaaaaaag cggcgcagct gaccggaaaa gaaaaagtcg ttgatgcgta 798601 ttgcggcgtc ggcactatcg gcatgtgggt tgcggacgga gcgaaggaag tccgcggcat 798661 ggacgtcatc aaggaatcaa ttgacgatgc taagaaaaac gccaaaaaac acggcatggc 798721 aaatgccaca tacgtaacag gaacagccga gcactggctc ccgaaatgga cgaaagaagg 798781 cttccgcccg gacgtcgtca ttgtagaccc gccaagaacg ggctgtgaca gcacgttctt 798841 ggacacgatc aaaaaagtca aaccgaaacg ctttgtctac gtttcctgca atccatccac 798901 gcttgcgaaa gatttgcaga cgctgtcgaa ggactatcgc gtggactata ttcagcctgt 798961 cgatatgttt ccgcagacgg cgcatgttga agcagtggcg aggcttgtat taaaatcgtc 799021 taactaaaaa gaacatttcc cagtcataaa atagttttcc taataagacc tggatttcgg 799081 taaaataaac aattccgatt tccgggtctt tttcgtgcgc agctcttgtc ctaacggtct 799141 gttctcaatt ttatcttcct tcttttcgcg gagatcttta ttttaactgg cgaaaagaat 799201 tgaaaaaacg tgttgaaaag caggtgaaaa aaagcgttat ttaaccggaa aaatatcctc 799261 ccagtatgtt taaaatacat gagtagaatg atgtaaaatc atagatgtat tttcataatt 799321 tgtaaaatta tatattgact tgcagttatt acgtgtgaaa tattgatgat aggaatataa 799381 ggaaagtatg gcgtatatca tttcaagagt cattcgatgt aaaaagttga aacattgtaa 799441 taaatgaaag aggtgaaaat gatggccaac cccattttaa aatgcataac gtatgagcac 799501 tacaacaatt aaataatagt gccgagacga taacaactat tacagtaata cctacaatgg 799561 ttatatcctt gcgacaatca tgcttcataa tataatgatt ttagattgac acttggctaa 799621 aaagtattgc agagaaggaa atggataatt aaatggataa agtatataaa agaagttggt 799681 ttcaaacatt tttggcattt ttagtatctc agctttattt taattttgta gaattaacgg 799741 gatggggtcc taagtataga gaaatgaatg gattcccagc aaacatagtt gaactagatt 799801 tctttcaaac atatctttca ttctatgata atccatggtt taatattatt actgttttct 799861 tgggagtttt cactattata caaataatta cagggataac aaaggatatt cgaaattaaa 799921 gcaataactt ctgatgcctt atttaatgat gaaagaaaat gtacactttc ttaattatct 799981 tatgagtgaa gactgcgaca cttagtcagc agtctatttt atggttctgg atcaggatta 800041 ccgaattata accctataca aatatatagt aggttgccac ttgctgcgtt ggttattttc 800101 taaatcatga gcaaatccca aatgattcag attgaagttc ttgaattctt ttaaataagg 800161 gtttattttc tcttctcatc ctctttactc catgtgattc acaagtggta gcagcttaag 800221 taggtttttt cattctcttg agtactcagt tataccaccc ccaactcaat ttgctttatc 800281 tctattagtt tttccgcaaa tatgatatag agatacggat atggtgtagt gttaaatatc 800341 ttatcttcaa taacagggca attattttgc gttggtaata tggagaactc atatgatatt 800401 ctatttaggt tggaatcctt tttatccaaa aagttcaaaa gcaaggccac taagaaagac 800461 gaaggtcagc gccagttaac cagaatataa aaaatagggt agataatcat cccacgtgaa 800521 atcttcaaaa tttactatag attgataaga aatgctttcg catgcgataa gtgtaaaaga 800581 agcatggtca gtttttaatt tgggataaag gttcagccgt atcccataat gaaaggattt 800641 gatttttgtt atgacagaaa atttctggcg tgaattacca cggccgtttt ttgtactggc 800701 accaatggaa gatgtgacag atgttgtttt ccggcatgta gtaagtgaag caggcagacc 800761 ggatgtgttt tttacagagt tcacaaactc agagagctat tgccacccgg atgggaagga 800821 tagcgtgcgc ggccgtttga cttttacaga ggatgaacag ccaattgtgg cccatatatg 800881 gggagataag cctgaaaact tccgtaaaat gagtattggc atggcagagt taggatttaa 800941 aggactagat atcaatatgg gctgccctgt gcctaatgtg gcggggaatg gaaagggaag 801001 cggccttatt tgccgtcctg cagttgcggc agaattaata caagctgcaa aagcaggggg 801061 attgcctgta agcgtgaaga caagacttgg atacacggat gtggatgaat ggcgcgagtg 801121 gctgacacac attttgaaac aggatattgc gaatctttct attcatctgc gtacaagggc 801181 agaaatgagc aaagtagatg cgcattggga gctcatccca gagattaaga aacttcgtga 801241 cgaggtggca ccagatacat tgctaacaat aaacggggat attcctgacc gtcaaactgg 801301 cttgaaactt gctgaacaat acggcgtcga tggaattatg atagggcgcg gtatttttac 801361 aaatcctttc gcttttgaaa aggagccgaa agagcatagc agcaaggaat tgcttgatct 801421 cttaaggctg catctggatc tccatgatga atattcaaaa gaagaagccc gtccatacaa 801481 gcctcttcct cgctttttca agatttatct ccgcggattc cgaggggcaa gtgaattaag 801541 aaatcaatgc atgaacacaa agtcaacaga tgaagtgcgt gcattgctcg acgactttga 801601 gagaaagtat cttgatggga tagagtaaca gcagtgcttg attcaaaaaa ggctaacaaa 801661 ataaagggat ttttacacaa ttcttgacta aaataaacct ggattttcgg taaatccggg 801721 tcttttttgt acgcagcttt tactcagcct gtcttttctc taatttattg taagaaaata 801781 atggtatatt tagtggagat atcatataaa gggggagagg aaaatgaaac ggctatgcat 801841 catcccctgc ggcaagaaaa aaatctggga tgtccagcct gatgccgggc cggtaagagc 801901 agaggacgct tatctcagcc cgtttcatca ggcgtgcgag cggtatgcaa aaacattttt 801961 cgatgagtgg gtgattttgt cggcgaagca cgggttcctc cgccctgatg atctcgtttc 802021 gggaaattac gatgtcactt ttggcaccgg tcatccggaa atcatgacag cggacgagct 802081 gcgccgtcaa tttcacgaaa aaggcttttc tgatatcgaa gagctagtca tgcttggcgg 802141 aaaaaaatat cgaagcgttc taaacgccgt catcggagaa caccagcata tcagctggcc 802201 gctatcatca tacaaaggca taggctatat gctccaagcg ctgaaccggg ctgttgaaga 802261 aaagcatgaa ctgtagcacg tacatatgag gaaaagagtg ggaacatgaa aaaacttgtg 802321 tttggcttgc ttgccattgt gttattcgga tgcggactat atatctatca tgtatggttc 802381 ggtgatccat tttcgaaaaa tgctgcagaa cagaagctag tgtcttatgt gaaacaaacc 802441 tatcctaaga aagaaatcaa gatcacgaat ggggtatata acgctaaaac gtctgaatat 802501 gtatttgaag caacctccca atctcatcgc tacccaatgt gtacgaaggg atttctgcat 802561 cctaaagtaa cgtgcgatgg aattgaagaa gcgtataccg aatcagtagc aaaacatgta 802621 aatgaagaag caacgaaggc aatcgaagca gatctgaaaa aagcggttcc tcgatttata 802681 aaagctgatg ctgctttgag tatcgaaaac ggacagttca cgttagatac aaaatggaac 802741 aaaaagctgg ctgaaaaagc gcctatgagc atgacgattc agttagacgc cagcgggtta 802801 tcaaaaacag atgccgcaaa gatggcggaa acggtcagaa aaacgcttaa tgaaaaggga 802861 tatacatact caaacggcac gatagactgt atgcagaagg acggggacgg cggtattgga 802921 tatgtcaaat attcaattga ttttctttca aaagcagcta ttcagtcaaa cgatgcagag 802981 gaactaggaa gttaaaaaga tttccaagga aataaatacg tcgatcattg tcaaaggccg 803041 ggtgatatcc ggtctttttt ttgcatgctg taaaacgaga caaatgaatc agtttgagac 803101 aaaacgagac acacgtctca aactgtctcc aaagtgaaga tgagaagact gattttacgg 803161 gctcaaaaga ctggcacact tcttgcattt ataatggtga accctaaata gaaggaggcg 803221 cacaaaatga aattgttaaa acgagaaggc ttgtcattaa ctgaggaaaa agcgctgtgg 803281 atgtaccaaa agatgctgga gatcaggggc tttgaagaca aagtgcatga actgttcgcc 803341 cagggagtgc ttcccggatt cgttcattta tatgccggtg aggaagccgt ggctgtaggg 803401 gtgtgcgctc atttacatga tggcgacagc attacaagca cccacagggg acatggacat 803461 tgtatcgcca aaggctgtga cctggacggc atgatggcgg aaattttcgg gaaagcgacc 803521 ggattgtgca aaggcaaggg cggttctatg cacattgcgg atcttgataa aggcatgtta 803581 ggcgcaaatg gaatcgtcgg gggcggcttt acgctcgcat gcggatcagc gctcacggct 803641 aaatataaac agactaaaaa tgtaagcgtt tgctttttcg gggacggggc aaataaccaa 803701 ggtaccttcc acgaagggct gaatttagcg gctgtatgga accttcctgt cgtatttgtt 803761 gctgaaaaca acggctatgg cgaagctacc ccatttgagt acgcatcagc ctgtgattca 803821 atcgccgatc gggcggctgc ttataacatg ccgggggtta cagttgacgg caaagatatt 803881 ttagcagttt accaggcagc cgaggaagcg atagaaagag caagaaacgg cggcggcccg 803941 tctttgattg aatgtatgac ctacagaaac tacggccatt tcgaaggaga tgcccaaacc 804001 tataaaacga aggatgaaag agttgagcac cttgaagaaa aagatgccat tcaaggtttt 804061 aaaaactacc ttttaaaaga aacagatgct aataagctgt cagacattga acagcgtgtc 804121 agcgaatcga ttgaaaaagc cgtctcgttc agcgaagaca gcccatatcc aaaagattcg 804181 gagctgctga cagatgtgta tgtgtcatat gaaaaaggag gaatgtaaga gatggcgaga 804241 gtcataagca tgtcagacgc gatcaatgaa gcaatgaagc ttgcgatgag aaaagacgaa 804301 aatgtgcttt tgatcggtga ggatgtcgcc gggggagcgg cggtcgatca tttgcaggat 804361 gatgaagcat ggggcggtgt attaggggtc acaaagggac tcgtacagga attcgggcgt 804421 acaagagtgc tggacactcc gatttctgag gcaggctata tgggagcggc tatggctgcg 804481 gcatcaaccg gtttgagacc gattgccgag ctgatgttta acgattttat cggcacgtgc 804541 tttgatcagg tgatcaacca aggggcgaaa ttccgttata tgttcggcgg aaaagcgcaa 804601 gtgccgatta ccgtccgcac cacatacgga gcagggttcc gggccgctgc ccagcattca 804661 caatcgctgt atggcctttt cacgagcatc cctggactga agacagttgt tccatccaat 804721 ccgtatgatg ccaaaggtct tttgcttgca gcaatagaag ataatgatcc ggtgtttttc 804781 tttgaagaca aaacgtccta caacatgaag ggcgaggtgc cggaagatta ttatacaatt 804841 cccctcggaa aagcggatat caaacgcgaa ggcaatgatg ttacgctctt tgcagtcggc 804901 aagcaggtca atactgcgct tgaagcggct gcacagcttt cagagagggg catcgaagcc 804961 gaggtccttg atccccgcag tctgtctcct ctggatgagg atgcgatttt cacatcgtta 805021 gaaaaaacaa accggctgat catcattgat gaagccaatc cgcgatgcag cattgccacg 805081 gatattgctg cgcttgtcgc tgacaagggc tttgatttgc ttgatgcgcc gattaaacgg 805141 attacagcgc cgcatacacc ggttccgttt tcaccagtgc ttgaagatca atatttgccg 805201 acaccagata aaattgtcag cgtcacgctt gaattgcttg gcgagccggc attgaattaa 805261 aggggggaca caaatggcgg taaaagtagt gatgccaaaa ttgggaatgg ccatgaaaca 805321 aggggaagta tcgatatgga ataaaaaagt aggcgacccg gttgaaaagg gagaaagcat 805381 tgccagcatt caatcggaga aaattgaaat ggagatcgaa gcgcctgaaa aaggaacgct 805441 gatcgatatc aaagtgaaag agggagaaga ggttccgccc ggcacagcta tctgctatat 805501 cggggacgcc aatgagtcgg tgcaggaaga ggcgggggcg cctgttgctg aagacaatat 805561 gccgcaagcc gtccagcccg tcaaacaaga aaacaaaccc gcagcctcca aaaaagatcg 805621 aatgaaaata tctccagtcg ccaggaaaat agcagaaaaa gcaggattag acctaaaaca 805681 actgaaagga actggaccag gcggacgaat cgtgaaggat gacgtaacaa aggctcttgc 805741 tgaacagaaa aaagatcaag caaagcctgt ttcggagcag aaagcgcagg aaatcccggt 805801 gacaggcatg agaaaggtca tcgctgcccg aatgcaggaa agcctggcaa acagcgcgca 805861 gctgacgatc acgatgaaag ctgatatcac caagcttgcc actcttcaaa aacagctttc 805921 accaactgcg gaagagagat acggcacaaa actgacgatc actcattttg tctcaagagc 805981 cgccgttctc gctctgcaag ctcaccctgt gctgaacagc ttttatcaaa atgagcgcat 806041 catcacacat ccccatgtgc accttggtat ggctgtagcc ttggaaaatg gcttagtggt 806101 gcctgtcatc cgccatgctg aaaagctatc gctgattgaa ctggctcaat ccatctcaga 806161 aaatgccaaa aaagcacgcg agggacgtgc gggaagcgaa gaactgcaag gatctacttt 806221 ctccattaca aaccttggcg cgtttggagt tgagcatttc acaccgatac taaatccgcc 806281 ggaaacaggc attctcggca tcggagcaag ctatgacaca ccggtgtatc aaggggagga 806341 gatcgtcaga agcacgatcc tgccactcag cctgacattt gatcacagag cgtgtgacgg 806401 cgcccctgcc gctgcattcc tgaaggcgat gaaaacatat ttggaagaac ccgcagcatt 806461 aattttatag gaaaagcagg tgaaaacgac atgacattag ccattatcgg cggcggacct 806521 gcaggctatg cggctgcggt ttccgcggca cagcagggca gaaacgtgct gctcattgac 806581 aaaggcaagc ttggggggac ctgcctgaat gaaggctgca tcccgacaaa gtctttgtta 806641 gaaagcgcaa acgttcttga taaaatcaag catgccgaca gctttggaat cgaacttccg 806701 gcaggtgcga tatcagtcga ttggagtaaa atgcaaagcc gaaaacaaca ggttgtcagt 806761 cagcttgtcc aaggcgttca gtacctaatg aagaaaaatc aaatacaggt tgtaaaggga 806821 acagcctcct ttctttctga aagaaagctc ttgatcgaag gagaaaacgg aaaagaaatc 806881 agagaggcgg accaagtatt gattgcctcc gggtcagagc caatcgagct gccttttgcc 806941 ccatttgacg gcgaatggat cctcgacagc aaagacgcgc tttctctttc cgagattccg 807001 tcttcactag tcattgtcgg cggcggtgtc atcgggtgtg agtatgcagg gctgttcgcc 807061 agattgggat cgcaggtgac catcattgaa acagcggacc ggctgatccc ggctgaagat 807121 gaagatattg cccgtctctt tcaggagaaa cttgaggaag acggtgtcga agtgcatact 807181 tcatccagat tagggcgggt ggatcaaacg gccaaaacgg caatatggaa aagcggtcag 807241 cgagagttta aaacgaaggc cgattatgtg ctggtggcga tcggcagaaa accccgtctt 807301 gacggattgc agctggaaca ggccggagtt gatttttctc caaagggcat tccggtgaat 807361 gggcacatgc agacgaacgt gcctcatatt tacgcgtgcg gagatgctat agggggcatt 807421 cagctcgcgc atgccgcttt ccatgagggc atcatcgctg cttctcatgc ttccggaagg 807481 gatgtcaaaa tcaatgagaa acatgtgccg cgctgcatct atacgtcccc ggaaatcgcg 807541 tgtatcggaa tgacagaacg acaggcaaga agcatatacg gggatgtgaa gatcggcgaa 807601 ttttcatttt ccgcaaacgg caaggcgctc attaaacagc aagcggaagg aaaggtcaaa 807661 atcatggctg aaccggaatt cggcgaaatc gtgggtgtct cgatgattgg cccggatgta 807721 accgagctca tcggccaagc ggcagcgatc atgaatggtg agatgacggc agatatggcg 807781 gagcatttta tcgccgccca tccgacttta tcggaaacat tgcatgaggc gctgttaagc 807841 acgatcggcc ttgcggtaca tgcataataa aggaaaaagc aggcgcatgg atataaggcg 807901 cctgcttttt tattgttgaa agcgctttat ttttccccta caatagatga aaacggcgtg 807961 taagggagga gcgatcaagg aaatgaattc ggtcccaaac gatttgcaaa cctggaaacg 808021 ttttgtgaaa gacggtgtgc ttgacgaagc ccgattaaga aaacggattg cagagtcatg 808081 gcatcgctgc aaaaaagctg aggtcaatcc ttatttagaa aaaggcccga aggttttaca 808141 gcaaacggag ctggatcagc agtcaaaaaa acattcattc ttcttgacga ccgcaaagcc 808201 ttacctcgaa aaactgctgc ctgccataaa agaaatggaa atgatggcgc tgttaattga 808261 ttcagacggt gttgttctgg cattggacgg ccatccgcgc gcgctctatg aagccaaacg 808321 catcaatttc gtcgaagggg catgctggac agaaacggct gtcggaacaa atgcgattgg 808381 cacggcgctc cacatcagcg agccggttgc aatacaagga tcagagcatt actctatcgc 808441 ttcccatctt tggaactgtt cagctgctcc gattcaccat gaggatggca gccttgcggg 808501 tgtaattgac atatcatgcc cggcggcagg cgcgcatcct catatgcttg gtattgccac 808561 ggcgattgcc tatgccgctg aacgggaact cgcagctaaa agccgtgaga aagagctgga 808621 gctgatcagc cgttttgggg agagagctgc atccagtgtg ccgatggtgc tctgtaatac 808681 caagcagcac atcatcagtg cgagcatgcc gattcgaacc tcaatgccgg attggcaggg 808741 ccggcacctg tacgagttga aggaacgggg ctattcaatc gaaaatgctg tcaccatagg 808801 agatggcggc acttgttttt atctttcgga acaaaagaaa aagaaggcgt ttcgattcaa 808861 tggagtgatc gggcaaagcg gccgatcgca agcgatgctg atgcaccttg aacgagcagc 808921 tgcgacggat gcatcggtct gtttgtcggg tgaaacgggt acggggaagg aggtcgcggc 808981 tcgcgcgctt catgagaaca gtgagagacg gcacggtccg tttgttgctg tcaattgcgg 809041 agcgattccg tctgatttga ttgaaagcga actgttcgga tatgcagagg gcgcttttac 809101 gggagcgaaa cgaaatggct ataaaggcgc ctttcaaaaa gcgaatcaag gcacattatt 809161 tttagatgaa atcggagaaa tttcccactc gatgcaggtt gcacttttac gggtgcttca 809221 ggaacgcaag ataacgccaa tcggcgggac gaaagaaatt ccggttgata tcagagttat 809281 tgccgccaca cattgtgatt tacgcgagct tgccgaaaac ggaaaaatca gagaggactt 809341 gttttaccgt cttcatgtct atccaattga actccctcca ttacgcgatc gcaccgagga 809401 tatcccggat ctctttgagt actacaaaca gaagaatcat tggccaggcg atcttccttc 809461 tgatttttgt aatgtgctga agcaatggaa gtggccgggg aatatccgcg agctgtttaa 809521 tgtgtttgaa cgtctttcta tcagatttcc ggacggccgg ctgagagatg aatcgcttcc 809581 cgctttactg gaagccgctg gattgccggc cagctctgca gaaaaaaagc cggctgctgc 809641 cggcgtgctt acttttcgtg agcaaatcca aaaggatatg atgatcaaag cgcttgaatc 809701 tgcaaaagga aacgtctctc aagccgcaaa aatcagcggg atcccccgaa gcactttcta 809761 caaacgcctg aaaaaattca acttgtccgc tgaatcataa agcatacttc cttcaggaaa 809821 tggaaacgtt atgtattgaa ggagggtgtt acgatgaata ttcaaagggc gaaagaaatt 809881 gtagaatctc ccgacatgaa gaaagtaaca tataacggcg ttcctattta cattcagcac 809941 gtaaatgaag aaactggaac agcaagaatt tatccgcttg acgaaccgca agaggagcat 810001 gaagtgcagc tgaacagctt aaaagaggat taaacaaaaa tggcccgctt cataagcagg 810061 ccattttgtt atccgcgcgg cgcaaataaa ataacacaga caccgatgag acaaatgaat 810121 gcgccgatcc agtcatacag atcaggtgtt ttccggtcaa caagccatcc ccacaggacc 810181 gcaagcacga tgaatactcc gccataagcg gcgtatacac ggccgaaaga tgggaaggac 810241 tgaaacgtcg gaagaatgcc gtatacaatg aggatcagcg ccccggcgat tccgtagcca 810301 gctggctttg cctctctcag ccatagccaa accagatatc cgccgccaat ttcagcaagc 810361 cctgccgcga gaaataaaag aatggtaatc agcatcatga gcactcctca atttgcattt 810421 atctttcatt atagaggagg agagctttta aagcttcgga tgattctcaa attccttcaa 810481 atacgctttt cgctgaacct ctgtaaattg gctgatccaa ttgttttgag cctcttcatt 810541 caaatgggga aggatatagc gttcaaccgc ttcgaaaaac agcggattcg tgatgatgtt 810601 ccaggtcggg attcgaacga ttttgccgtc tgttttctcg atgataatat cctcaaaaaa 810661 gatccctttc aaactgtatt gatggcgtcc catataaagc cgcttcacct cggaaaacag 810721 cacgctgcgc tttctcaaga agatttcgcc actaggtccg gtctttatgg tgaaaatgac 810781 atttccacgg cttgtgaacg caggaaaagc cataaagaat gtgatcaatc cataaatcat 810841 cgccagtaat ccgccgccca aataaagcag ggcatattta gattcaaacg tgagggcttc 810901 agacaccagc cagactccca caataaaggc gccccctgta gcgaggaaca gccaagccct 810961 tagaaacatc atgcttttta cttcaatcat gtgctgcccc taaagcttcg gatgattctc 811021 aaattccttc aaatacgcac tgcgttggat gtctgtaaac tgtccgatcc aattgctttt 811081 cgcctcttca ttcagatgtg gaaggatata gcgttcaacc gcttcgaaaa acaacggatt 811141 cggaatgatg ttccaagtgg gaatgcgaat ggtcttctga tccacggttt ggatcaatat 811201 atcttcttgg aagattcctt ttagactaaa tttatggcgg ctcatctcaa ttttcttgat 811261 atcagtaaac gtaacagaca ctttgtcagt gaacacttct ccattttttc ctgtcttgat 811321 gcggaaaatg gtatttcccc gcggggtgaa agccggaaag aagatgataa ataaatataa 811381 acaaaacaag gtgaacagaa agccagcagg aatggctaat aggtaatatt tcgtttgaaa 811441 cgtaataccc atataaaaga gccacaaaca tgctaatccc ataccggcag atccgacaaa 811501 agcccatatt ctcaggaaca ttttgctttt gacttcaatg atttcttggt ttttcaatgc 811561 ttttctcctt ttgttaattc aattcttatc attttgaaat gatttgattt acaacatcct 811621 tatgagcagg gaggatagaa aattcattct gggtgatgcc tgtgacaagc caagtatggt 811681 gggcccccgg caggacgaat gccatgtcag ccacttcagg agtgttatct tttccatatg 811741 ccagacgcat aagtgtatcc attttccctt tccgcaaagc cagatcattt gcaaatcggg 811801 taacgtcctc ttggtggtca tgtttttcaa ggaactcttt tagatatgaa gggttgtctg 811861 aagcgccctc caagagtttt tcaaattcat ttgatgtcaa tgttacaatc gattctcttt 811921 tatcctctgt atctattata tgtaaaaact catctgtctt agcaagtaac ccttcacttg 811981 attccatttt tgtaatgcga tggacttgtt catcaaaaag gagttcgtga gagtaggtgc 812041 cgaattttga tacatggcat gacacattct gttcggcacc ttgcccgtta aatttagaaa 812101 gcttcactgt atagtcagcg tcgtttaata catggataaa cggacagtac tcgtccttta 812161 accgatattg atggttccga tattccgctg catccttggc taagagtgag cggcacgcgg 812221 cttcaaataa ggcgccgagc tgttcatctt ctatttccgg aaaataggcc tgcttcaagg 812281 ccattccctg ttcaaaaaac ccttcgctgt aaaagcaaaa caagagttct tctatgctaa 812341 ttgtaaactg cttcattgtt tattctccta tccaaatgaa aatttccctt taaggaaatg 812401 ggttgcgccg tgtataagcg aatccgctgt tttctttgct ttttccattc cttttttcgc 812461 gctgtctatc cctttatgta tcgatttatt cgccgcatct atgccgtcat tcactgattt 812521 gacgactttg ccggctgatt ccagcccttt tttggctgta tcaacaacag catggatcgg 812581 ttctttcagc tttaaggctg ctttttcagc aaaaccggct gtatatttgg cgatttgttc 812641 tccgacgact ccgccaatgt atgaacctgc tgccccaaga aggacagtac ccacaggtcc 812701 tgcaaagctt ccgattgcac cgccgatgac agcaccagct gtggcaccgc cggcaacaaa 812761 aatcgtatta ttcacagcat tcccgacggc cttggcgttt tcacgcttga gaacttccgg 812821 tttatcctgg tattttgcat aattttcagc aattttcacg cctgctccga atgtttcggt 812881 cgctccggta atcagtgtgg cggtaatggc atttcctttc gcgaatctca agcccgtttt 812941 tcccacatcc ttcaaagtgg agcgtacgcc ggcttcatta agaaatcctt ttgtgtagct 813001 tctgacgctg tttgaaaaat ccaccgtgtc ctgaggaaag tattttgtaa actttttatg 813061 taccaaatct gaaaatggac ggtttgtctt tttcaacaaa tatttaggat tcaaaagcac 813121 tcttgccgct ttttgataac gtgagctgtc aacggccctg gaaatatcca agagcagttt 813181 tgagtgctgg gctgtatgca agccgcttgg ttgtttcaca aatttcgtaa gccctaatcc 813241 gtaatatttt ccctgcgtca gcataagagc ggttaagctt gtcatcgtac cgtatttgtc 813301 gtaggcattg tagagctttc gcaaaatatc atcttgttcc acaaatttat cgcctgtttt 813361 tctgatgaaa atctcattgt cactcagctt agtgacgagc gcctttcctg agctccacgc 813421 atcgcccact ccagaaaaac agctgctgta gcggggatcg cattgcaaaa tcatctgccc 813481 cagctccaca tgcaggtcct tatatttgtt ttccatatca gttaattcag tgactacatc 813541 atttgcaagc tgttcgagct tatccggatc aactgcaatg tttcctgaca caccgttcac 813601 ctcccgagtt tatgtctttc ctctcttgct ttacgctcca gttcttccat tctggcaatt 813661 tcagcttttc gttcttctat tttgacagcg gcagccttca gctcttggct tgtttcaagc 813721 agctcctgtt cgaattgatc gtaggcggct ttcgtttcct cgaaatcctg gtcaaacgaa 813781 tctcttgctt tgccctgcca agcatctccc aatgcagata accgggattc aagcagcatt 813841 ttggagcttc tgacctcttc tgcggccgca ctatacttgt ttgccagctc aatgacttta 813901 tatgagtcca acttttgtcc cctgcctttt ctaaattcac gcacaattgg atgttttata 813961 taaatgatta taaataattc ggcatgtatc cgaatcgtac aaaagaacct tttcataaga 814021 attggaaggg cgtatattca cttaaaattc acagttggtg agactttaag attacaaaaa 814081 aggtaaaaaa accaaatctc tcagacataa ggcaaatgag aaatttcccg ctctatggga 814141 aaaaacacta aagttgatca aatgacctaa gtgcgccaaa cgtgttacgg gacgagctat 814201 ctcatggtat aaatggaatt gtaaacgtta tcaaggaggt cgtcatatga agaaaaaatc 814261 attctcaatc gtaatagcgg gcggagggag cactttcact ccagggatcg tactcatgct 814321 cttggaccat ttggaggagt ttccgatcag aaagctgaag ctgtatgata atgataagga 814381 gagacaggat cgaattgcag gcgcctgtga cgtttttatc agagaaaaag cgccggatat 814441 tgaatttgca gcgacgactg acccggaaga agcttttaca gatgtcgatt ttgttatggc 814501 gcacatcaga gtagggaaat acgcgatgcg cgcgcttgat gagcaaattc cgttaaagta 814561 cggagttgtc ggccaggaga cgtgcgggcc gggcgggatc gcatacggta tgcgttcgat 814621 cggcggtgtg cttgaaatat tagattacat ggaaaaatac tcgcctgatg cgtggatgct 814681 caattattcc aatccggcgg caattgtggc tgaagctacg agacgcctta gaccgaattc 814741 taaaattctc aatatctgtg atatgccggt tgggatcgaa gaccggatgg cgcaaattct 814801 tggcttatcc tcaagaaaag aaatgaaggt ccgctattac ggattgaatc atttcggctg 814861 gtggacatcg attcaggatc aagagggcaa cgatttaatg ccgaagctga aggaacatgt 814921 atcccaatac ggttatattc cgaaaacaga ggctgaagct gtggaggcaa gctggaatga 814981 cacgttcgcc aaagcgcgtg acgtgcaggc tgcagatcct gacacactgc cgaatacgta 815041 tttgcaatat tatttgttcc cagatgatat ggtgaaaaaa tcaaatccga atcatacgcg 815101 ggcgaatgaa gtcatggaag ggcgcgaagc ttttattttc agccaatgtg acatgatcac 815161 acgtgaacag tcctcggaaa acagcgaaat taaaatcgat gaccacgcat cgtatatcgt 815221 tgatcttgcc cgggcgattg cctacaacac aggtgaaaga atgctgttga ttgttgaaaa 815281 taacggtgca attgcgaact ttgacccgac tgcgatggtt gaggtgccat gcatcgtcgg 815341 ctcaaatgga cctgaaccga ttaccgttgg caccattccg caattccaga aagggctcat 815401 ggagcagcag gtatccgttg agaagctgac tgttgaagcg tgggcagaga aatcgttcca 815461 aaagctgtgg caggcgctga tcctgtcaaa aacagtgccg aacgcgcgtg tggcaagact 815521 cattcttgag gatttagtgg aggccaacaa agacttctgg cctgagcttg atcaaagccc 815581 aacccgcata tcataaatga aattccccca ttttcgaatc tgtaattgta tataatagaa 815641 agaaaatggg gggatctgat atgcagctcg aagaactgat caatcagcac tacagcaaat 815701 tgaatgacaa cgattttcat attttaaaat atatattgaa tcataagcac acatgctatc 815761 accttggaat cgacgcgctg gccaaagctt gcagtgtatc gcgttcctca attttacggc 815821 ttgcccaaaa gctcggtttc agcggttaca gtgaatttcg cgtcttttta aagtgggaag 815881 atcagccgga agaaggcgag agtatgagtt ttgaaaagct gcttgatgat attgaagcaa 815941 atttgaagtt tttacggaca aaggacatga cggacatgtg ccagctgatt gatgcagctg 816001 accgcatttt cgtctacggt tctggaaatg cgcaaaagat atgcgcccgc gacctgcaaa 816061 gaatgtttat tccgcgccat cgctatctta ttttgattga agacacaaat gaatttaatt 816121 tgatgcgcga tgattttaaa gtgaacgatc tgtttatcat catttctctt tccggagaaa 816181 caccggagct gattcctcag gcaagaatgc tttctgcaaa gggtattccc tttatttcca 816241 ttacgaattt aaaaaacaat gtcctcgccc agctgactcc gcataatctt tatgcgacaa 816301 gcaaacctgt gacattaagc gatagaacgg aaattgtcgc ttttgcaccg ttttttctcg 816361 ttggcgaagc attgttccgc gcatatgttg attacaaaga ggcagaaaaa aatgacaatg 816421 agtagcaggg ggttctggta tgatgcaaaa aattcagcgc tttggaagcg cgatgtttgt 816481 gcctgtttta ttattcgcgt tcgccggcat tatcgtcggt atcagcacgc tctttaaaaa 816541 taaaaccctc atgggaccgc tcgccgatcc tgacggtttt tggtatcagt gctggtatat 816601 cattgagcag ggcggctgga ctgtttttaa ccaaatgccg ctcttattcg ccattggcat 816661 cccggttgct ttggcgaaga aagctcaggc acgcgcctgt ttggaagcgc ttactgtcta 816721 cctgacattc aactattttg tcagcgcgat attgacggta tggggaggag catttggcgt 816781 cgacatgaat caagaggtcg gcggaacgag cgggttaacg atgattgcgg gcataaaaac 816841 gctcgatacc aacatcatcg gagccatctt tatttcttcg attgtcgtct ttttgcataa 816901 tcgctatttt gataaaaaac tgcccgattt tctcggcatc tttcaaggct caacatatat 816961 cgtgatgatt tccttcttta ttatgatccc aattgcgttg gctgtgtctt atatttggcc 817021 gatggttcaa tcgggaatcg gctcgcttca aagcttcctg gttgcttctg gggcggtggg 817081 cgtttggata tacacgtttt tggaacggat tttaattccg accggccttc atcactttat 817141 ttacacgccg tttatttatg gcccggctgt agcggaaggc gggatcgtca cgtattgggc 817201 acagcatctc ggcgaatatt cgcaaagcgc caaaccgctg aaggagctct ttccgcaagg 817261 cggattcgcg cttcacggca actcgaaaat cttcggtatt ccgggtatcg ccctggcttt 817321 ttatgtgaca gccaaaaagg aaaagaaaaa actcgtcgca gggctgctga ttcctgtcac 817381 actgacagcg attgtcgccg gtattacaga gccgattgag tttacgttct tattcatttc 817441 acctttctta tttgcggttc acgccgtgct tgccgccaca atgtcgacag ttatgtatat 817501 ggccggcgtc gtcggaaata tgggaggcgg actgattgag gcggtaacct tgaactggat 817561 tccgctcttt ggcagccacg gtatgacata tgtgtatcaa attttgatcg ggctctcgtt 817621 tacagcaatt tattttttcg tcttcagatt tttaatcctc aaattcaata tcgctacacc 817681 aggacgggaa aaggatgaac agcaggaaac aaagctatat tcgaaaaagg aatacagaga 817741 acgaaaaaac aaggatgaaa cggcctccgc tgctgaaacg gctgatgaca ccgcttttct 817801 gtatattgaa gcgctgggcg gaaaagacaa catcactgaa gtcacaaact gcgccacccg 817861 cctcagagtc agtgtcaagg atgaaacaaa ggttgaaccc gacagcgtat tccgcgcgct 817921 tggcgcacac ggcgttgtca ggaacgggaa ggcgtttcag gtaattatcg gattaagcgt 817981 gccgcagatg cgggagcgtg tggaaaaaat attgaatcaa taaagactgc cctccttttc 818041 gggagggttt tcgtttgccg tcaaaaagac cgccatagta aagtaaagaa agagacaatc 818101 gagtaaaaag gggtttggag gcttttacat gcaaaaggct ttgtcgtttt taaaaccata 818161 ttcattgctg gcgggaattg ctctgattct tatgctgacg gagcttgcag ttgaactgat 818221 gcagccttta ttgattgcaa aaatcatcga cgatgggata ttgaagcaag atctgcggca 818281 tgtatggata tggggcacgg tcatgatcgg gctgaccgtg ttatcctttg cggcggggat 818341 gctgaattcc ttttatgccg cccatgtcag ccaaagcttt tcctatgata cgagaaaagg 818401 gctttttcaa aaaatccagt ccttctccta ttccacattt ggacagtttt cgtcctcttc 818461 ttatattaca aggctgacaa acgacgtcac acaggttcaa aatatgattt ttatgagttt 818521 gcggtttatg ctgcgggctc ccttaatgat tgcaggcggc attgtgctgt cgcttgccgt 818581 taatgtgaaa ctcgggtttt ttctgcttgt gaccattccg atcctgatct tgtttttgct 818641 atgggtatta aggaaaggcg gggcactgtt ccgctcagtg cagaaaaggc tggatcaagt 818701 gaacaccatc atgcaggaaa atttaattgc aatcaagctg atcaaagcgc tgcttcgcgg 818761 cagccacgaa gtcaaacgat ttatcaaagc caacacaagg ctgatggaaa aaacggtttc 818821 ggcctttcag cttgtggaat tcacgatgcc tgtactgatg ctgctgatga atctctgcat 818881 ccttttgatt ttgtgggcgg ggtcctacag tattacgagc ggaagcactc aggttggcga 818941 tgttgttgcg ataattaact acgcaacacg aattacaggc gcgctttcga tgtttccgtt 819001 tttgattatg attttcaccc gggcgaaggc ttcaggggat agaatcggtg aggtgcttga 819061 aacagaaggc gacgagcggg aggaaggcac catatctgat cgtttgtcag gacggattga 819121 gtttcagcat gtatcctttc gctatcctga aatggacaga gaagcgctca ggaatgtctc 819181 attttccgca aagccaagag aaacgatcgc gattctcggt gcgacgggct cgggcaagtc 819241 cacgcttttt cagctcattc cgcggcttta tcagccggat tcaggccgca tttacataga 819301 tgaaaagccg gttcaagata ttccggctga agggctgcgc aggcaaattg gatatgtacc 819361 gcaggaagtc ctcttgtttt ccggcacaat caaagaaaac atcgcttggg gcaaagaaaa 819421 tgcttcacta gatgaaataa tggatgcggc aaaacttgcg caaattcatg aaacgatttt 819481 aaagctccca aatggatatg acactgtttt ggggcaaaga ggcgtcaacc tgtccggcgg 819541 ccaaaagcag cggatttcca ttgcgcgggc gctgattcga aaaccggcta tccttctatt 819601 agatgacagc acaagcgcgc ttgatctgca aacggaggcg aagctgcttg aagcaatcag 819661 cacataccat tgcacaactt tgatcattac acaaaaaata accacggcga tgaaagctga 819721 tcagattttg ctgcttgagg acggcgaact gattgaaaaa ggcactcaca gtgagctgct 819781 ttctgaatct cagttataca agcgcattta cgagtcacaa ttcggaaggg aggggagcga 819841 gtcatgctaa aagacatccg caagcctttc caatatccca aactgccaat tgacaaaaaa 819901 gaaggcgcga aaaagcgggc gaaagcaaag gatacaaagg gcacactgag acgaatctgg 819961 tcttacttgg ctgaaagaaa aggactgctc atacttgtca tgctaatggt tgtcatcagc 820021 gccatattcg gactccttgg tccctttgtg atcggaaagg ccatcgacca ttttatcgtc 820081 gggaaaacgg tcagcggctt gattcctgtt ttgcttcttc tgctcgctat ctatatcatt 820141 cagtccctgt cgctttggtt tcaaaactat tggatgatta cgatctcgca gggcacggtt 820201 ttcagaatga gaagcgaatt gttcacccat ctgcatgagc tgccgattcc attttttgat 820261 aaacagcggc acggcgagct gatgagccgg gtgacgaatg acatcgaaaa tgtcagttct 820321 accttaaaca cgtcagtcat tcaaattttg tcaagtgtga tcacctttgt cgggacgatt 820381 gcggtgatgc tgtacatgag cccgctcctt actttgatta cgctgaccat tattccggtg 820441 atggcagcga gcctgaaatg gatcaccaac cgaacgggaa agctgtttaa agaacagcag 820501 aaaaaccttg gtgatctgaa tgggtatatt gaggaatctg tttcaggcgc aaaggtcatc 820561 aaagcatatt cacgtgagaa gcagattact gctgaattcc tcgaaaaaaa cgctgcactc 820621 aagacgtcgg gcttttgggc gcagacgatt tccgggttta ttccgaaggt catgaactct 820681 ttgaataact taagctttac aatgattgcg gcaatcggcg gtttgtttgc gctgaaaggc 820741 tggatctcga tcggctccat cgttgtcttt gccgagtatt caagacaatt tacacgccct 820801 ttaaacgatc tggccaacca gtttaatacg atgctgtccg caatcgccgg cgctgaacgg 820861 gtgtttgacg tgcttgatga aaaagaagag cgcgaggatg aaaagaacgc cgtgcatcag 820921 cccatccaaa caggcagcat tgaattccgg gatgtgtcct tcggttacga taaagggcag 820981 cagacactga agcatttaca gtttaccgtg cctgcggggc agtccatcgc gtttgtagga 821041 ccgacggggg cggggaagac aaccgtcact aaccttctcg cccgttttta cgagcctaac 821101 gatggaaaaa ttttaatcga tggtacagat attaaaaccc ttactagagc aagcctaaga 821161 aaaaacatgg ggtttgttct tcaggattct ttcttatttc agggaacgat cagagaaaac 821221 attcgctacg gcaggcttga tgcttctgat caggaagtcg aagccgctgc aaaaacagcg 821281 aatgcccata gttttattga aaggctgcca aaagggtatg acaccgtact gacgcaaaac 821341 ggttcgggca tcagtcaagg gcagaagcag ttgatttcta tagcgagggc ggtgcttgcc 821401 gatccggttc ttctcatttt ggatgaagcg acaagcaaca ttgataccgt tacagaagtc 821461 aacattcaag aagcgctcgc ccgtttaatg gaaggaagaa caagcgtcat cattgcccac 821521 aggctgaaca ccattcaaag agcggaccag attgtggtgc taaaaaacgg tgaaatgatt 821581 gaaaaaggca gccatgacga gctgattcgg caaaaaggat tttacagtga cttatatgaa 821641 agccaatttg agaaatagac ctttgtcctg cacagaggtc tttttttgtt acagttttat 821701 agtactttta tttcattttc gtaaaatgta acaaaattac ttgacgtaaa caagttatgt 821761 atatatacta gcttacatta agtaagtgat aacatttatc aaggaggata aaatgaataa 821821 atcatttgaa attggcacat tacttttaag agttattaca ggtattatct tttttgttca 821881 cggtttatca aagtttcagg gaatggaggg caccatccaa tttttcggca gcataggcct 821941 tccaagcttt atggcgtatg tcatcgcagc gattgaactg attggcggag tgcttgtctt 822001 cttcggattg gctacacgta ttgtcggtgt actgttcgct cttacactga tcggcgccat 822061 catcactgtt aagctgaaag cgccattcat gggcaatgca gaatttgatt accttctgct 822121 tttgacatcc attcacctgg cgcttactgg aagtcgattc ctggcgctgg acccatttgt 822181 gtttaaagga aaaaagaacg gaaacgtttc agcataagaa aagaggcatg cagcatgacc 822241 agcattcatg aggatacaca cattggctat gccaaactca caattcgcag tctggagcgt 822301 tcgcttcagt tctactgtaa cgtcatcggt tttcaagtct taaaaaagac ggaccgccaa 822361 gcggaattaa cggctgacgg gaaacgcgta ctgcttattc ttgaagaaaa tccgagcgct 822421 gtcgtcttgc ctgaacggtc tgtgacaggc ctttatcact ttgcgattct tcttccggac 822481 aggaaagaac ttgggatcgc gctcgcccgc ctgattgaac acggcattgc tatcggacat 822541 ggagaccatg ctgtcagcga agcgctctac ctgtctgatc ctgacggaaa cggcattgaa 822601 atgtacgctg accgcccccg cagcacgtgg cagcgtgatc gggaaggaaa ctacgtcatg 822661 acgacaaccg ctgttgacat tgagggcctt ctggaagagg caggagatga gcggaaaaca 822721 tcgcttccga acgatacaat catcggacac attcatctgc atgtcagtga tttgaaagaa 822781 gcaaaggcgt tttatacaga tgtactgggc tttgacattg tcggaaacta tgcgggcatg 822841 tccgccctct tcgtttcagc cggggggtac caccatcata tcggcttaaa catttgggcg 822901 ggaagaaatg cgccgcctaa accgacaaat gccagcggac tagattatta tactgttgtc 822961 ctgccccacc aagaggagct ggatttggtg gcaaaccgag tcaaacatgc cgggtattcg 823021 attgaagaga cggaaaacag ctttcgtgtg aaagaccctg tttccggcgc ctatattaca 823081 tttgtgattt aactgcaatc cccttgccga aataacggca gggggatttt ttatttttgt 823141 ccgccttgtt atgatgagag aaccaacttg ttaggaggcg tttacatgga actcaaccac 823201 cttgtgacgg gcaaaatagc attaaatcaa tatgtgcatc gcttagagca aaaggatgtt 823261 tcattttacg tccactactg gggagcgatg acgaaccact ataacacact gcttcataag 823321 cattcctttt atgaaatttg ttacgtggta agaggtgaag gatattacct tgaaggcgat 823381 cgtacatatc cgcttcgtga acagacgatt tttttgtcaa agccggagca tttgcaccaa 823441 atcaaaagtg aaacagggct gttccttttt tacgtcgctt tcgagctgag cgaggatcag 823501 tcaagcgccg aatggatcaa agtgatggaa gaagtgaaac aaagcccctt tatcacaatg 823561 caattgaaag atggcgaacc gccgggcctg ctttggaaaa cgttaatgct gcaagcagcg 823621 caacctgtca atgcttttga caaagagatc ctatctcatt tgtcgcatgc attgatcctg 823681 tcattaatcc aaacctttct cccgtacgcc caacgcccga aacaaaagca gcccattcac 823741 acatcttctg ctttgctgac agaggtgaaa ctgcacataa aagacaatct gtcacagccg 823801 ttaaagctga cggatgtcgc tagccacttt catatctcag ggaggcattt atcacgttta 823861 tttgcagcag aactgggcgt cagctactca gaatttgtcc aaaatgaaaa aataaacaaa 823921 gctgccgaac tgctgaaatc aacgaatttg tcgattaaag aaatagcgga agaaatcggt 823981 ttctcagtac attatttcac tcgcgtcttt tccgctaaaa tcggcagctc tccagggctt 824041 ttccgctccc tttataaaga ctcaaaaatg accgcatttc aaatcaataa accttttcaa 824101 aaaatcgaac aggccaagcc gcacgaataa gatgtcctga aatgacaaaa caatgtcttc 824161 atatgataaa gacgcgagaa atctcgttgt cttataatct ttttagaaag cggttacaac 824221 aaggggtatt gctgaaggag ggatgcattg gcttatgctt ggtgtcgggt gctctgccat 824281 tcttgaaaga aggggaagaa agccgtgagt acaaaaaaga aagaggctgt aataggaaaa 824341 gaaagcttag ctcataaagg gcttttacga acgattacat tggtatctac attcggcggc 824401 ctgttgttcg gttatgatac gggtgtcatt aatggggcac ttccttttat ggcaactgca 824461 ggtcagctga atcttacacc tgttacagaa ggactggttg cgagttccct gcttctcggg 824521 gcagccttcg gggcgatgtt tggaggacgt ctgtccgatc ggcacggccg ccgaaaaacg 824581 atcctttatt tagccttact cttcatcgca gccacacttg gctgtacctt ttcaccaaac 824641 gcgtccgtga tgattgcctt tcgttttctg cttggactgg cggttggctg cgcttctgta 824701 acggttccaa cctttttagc ggaaatttcg ccggcagaac gcaggggacg aatcgtgaca 824761 caaaatgaac tgatgatcgt aattggccag cttctggcat acacctttaa cgccattatt 824821 ggcagcacaa tgggggagag cgcaaatgta tggcggtata tgctggtcat cgcgacactt 824881 ccggctgttg tgttatggtt cggaatgctc atcgtgcctg aaagcccgcg ctggctggca 824941 gctaaaggca gaatgggtga cgccctgcgg gtgcttcggc aaatccgtga agacagtcag 825001 gcacagcagg aaataaaaga aatcaaacat gcgattgagg gcacagcaaa aaaggccggc 825061 tttcatgatt ttcaagagcc gtggataagg cgcattctat tcattgggat tggaatcgcc 825121 atcgtacagc aaattaccgg tgtcaattcg attatgtact atgggacaga aattctgaga 825181 gaagccggtt ttcaaacaga agctgcatta atcggcaata ttgcaaacgg tgttatttca 825241 gttattgcgg tcatttttgg gatatggctt ctcggcaaag tccgtcgccg gcccatgctg 825301 atcatcggac agattggcac gatgacagcc cttctgctga tcgggatttt atccattgtc 825361 cttgaaggaa cacccgccct gccgtatgtt gtgctgagtt tgaccatttt gtttcttgcg 825421 tttcagcaga ctgccatttc tacggtgacg tggctgatgc tctcggaaat ctttcctatg 825481 catgtgcggg ggcttggcat ggggatcagc accttctgct tgtggacagc taactttctc 825541 attggattca cctttcccat tttgctcaat catattggga tgtcggcgac attttttatc 825601 tttgtcgcta tgaatatcct agcgattcta tttgtgaaaa aatatgtgcc tgagacaaaa 825661 gggcggtcac ttgaacagct tgagcattcc tttcgccagt atggccgccg cgctgatcag 825721 gaaatccaaa atcaaacaac tcacttatcg taacctgaga taccaggagg aatctatcaa 825781 tgaaactatc ttatgtaaca gacagcctag ggcatttgcc ttttgaagac atgctcaatt 825841 ttgccgcaaa gcttgggatc gatacacttg aaatgacaac cgggggctgg tcgccggcac 825901 ctcacttgaa tcttgatgaa ttgctgcaaa gcagcgaaaa aagaaaagaa ttttcacaag 825961 cgctggaaaa gcggaacatg acactttgcg cattaaactg ctcggggaac cctttagatc 826021 cgggtgaatt gggcaaatcg cacagagaca taactgacaa aacgatggag ctggctggat 826081 tattaggcgt caaaaaagtg atcatgatga gcggtttgcc agccggcggc ccggacgaca 826141 aagtgccgaa ctggatcaca tacacagtaa gctggcctcc cgttttaaaa gatatcctca 826201 actatcaatg ggaagacgtt gcgatcccat attggaagaa gcttgtcaaa aaagcggagg 826261 cctgcggcgt ggggaaaata gcgcttgaga acttcagctc tcaattagtc tataatcctg 826321 agactctctt tcggctcaga aatgcagtcg gcccgatggt cggtttgaat cttgacccga 826381 gccatttgtt atggatgggc gcagacccga tcatcgcagc aagggagctc ggctcagcca 826441 ttcaccatgt ccatgggaaa gatgtcagaa ttgaaagata tttatcggcg gtcaacggac 826501 ttttagaaac aaaagaagtg acagatcctg caaaccgggc gtggaattac gtagctgtcg 826561 gctgtggaca ggatttacag tggtggaagg aatttttttc agttgtaaaa atgatgggat 826621 atgaaggtga ggtttcttta gaaatggagg atctgacgat gtcacctgaa gcgggcatcc 826681 gtacttctgt agaagcttta aaacaaacca tcagccaata ggaggttttc atgatgctaa 826741 atggagaaag aatcatctct aagccgcttc gctgggcaat ggtaggcggc gggcggctca 826801 gccaggttgg atataaacat cgtattggag cgctgagaga caatactgct tttcaattaa 826861 ctgctggcgc ttttgatatc gatgccgaaa gaggaaaaga tttcggggtg aaccttggag 826921 tggatgcgga acgctgttat cccaactatc aaaccatgtt tgccgaggaa gcgaaaagac 826981 aggatggcat agaggtagta tcgattgcca ctccgaacgg cactcattat gagatttgta 827041 aggcggcgct tgaagcagga gtgcatgtca tctgtgaaaa accgctgttc ttcacttcag 827101 cagaggggca ggaaatcaaa gcgctcgcag agaaaaaagg gaaaattgtc ggcgtgacgt 827161 acggtttttc aggcaatcaa atgcttcttc aaatgcgtgc gatgattgaa caaggaatga 827221 tcggcgatat tcgcgtggtt gacttgcagt acacacacgg tttttgtgca acagatgaag 827281 gtgaaaagat aagcgctgca cagaaatggc gtgtcgaccc tgcgatcgcc gggccaagct 827341 ttgtgctggg cgatttatct acccacacgt attatatgtc acagcttatt atgccaaaga 827401 tgaaaattaa ggagctgctg tgtgaccgac agagcttcgt cggcagccgc gcaccgctag 827461 aggataatgc ccatgtgctg atgcattatg aaaatggagc ggtcggaacg atgtggacat 827521 cgtcaatcaa tgccggatgt atggatggcc atagaatccg gattgtcggc tcaaaggcaa 827581 gcattgagtg gtgggacagc aagccaaatg aactgacgta tgaagtgcag ggagagccgg 827641 gccagacact cgttcgcggc atgccgtatt tagatgatgt ttgcaacgcc gatgaacgac 827701 tgggcgcctt acacagcgaa gggctgtccg aagcatgggc caatatttat cttaaatttg 827761 ccattgcgat agacgccaaa aaccgtgaag atgaagaaat cttgaacaac ttggtttatc 827821 ctgacattga tgcagggatc gagggcattc gctggattga gaactgcgtg cgctcggcaa 827881 accaagggtc agtttgggtt gaatttaaat aaatgaggga atgcgccgca tatgacataa 827941 agttcatatg cggtttttat tttccagaaa ctcctgtcaa aaatgccctg aggcaggtat 828001 gataagaagg gaattgggta tcgggagtga tgagcgtgaa agctcttttt tttacgagaa 828061 tgttcacctt gatggtgagc tgtttaatgt atctgtccat tgtgaaagag gataactggt 828121 ttggatatgt atttatagca gcaggtgctg ccatgtatgc agccaatcat gttttgctga 828181 caaaagagac aaatgccatc tggttctgcc tgattgatat tgcaatcggc ttttcgttcg 828241 gatttatctt tcccggcaca ggtttgttca ttattatgct ttgtccggtt gcggtcgcct 828301 tttttctgcg ggggtttcct aaaagaacag catggtctgt cttatgtctt tcctctattt 828361 tatttttgac cgtcctcatc cgtacatatg cgatgttcgg caatgaattt gtcattgatc 828421 atttgactag catgacattc gttgtcttct gcggtgtcgt gggcaaatta atccgcaagc 828481 tgttggatgc gcaggatacg gcaaaacagc agtttcagga actgacggag tcccatctgg 828541 cgctgtctgc tgcacatcag gagctccatt tatatgcgaa gcaggttgaa gagctgactg 828601 ccatttacga gcggaacaga atggcgcgtg aaatccatga tacagtgggg cataaaatga 828661 cggcccttct cgtccagctg cagcttttgc gtgaatggca aaaaagagac agccaaaaag 828721 cggatgagac agtaggtgtc tgtgaaacac ttgcccgtga agcgcttgat gatgtccgct 828781 tatcagtacg cactctgcaa actgaaaacg atccttcgct aatcgaatcg ctgaaacagc 828841 tgacagagga cttttgcaaa aatgcaggag tcacaacaga atttgcggtc agcggtgatc 828901 ctgcaatcat cccgctgtct ctccatccga ccctgatcag aacggtgcag gaagcactga 828961 ccaatgccaa acggcacggc ggcgccgcag cctgttcgat acagcttgcc tgcacaacgg 829021 acagcatcag ccttgtcatt aaggatgacg gcaaaggcaa tcctgaggca gcacttggtt 829081 ttggtctctt gaatatgaaa aagcgggcag cggagcatgg cggaatgatc cgctttgaaa 829141 gcgaacggga tcaaggattt actgtaaatg cagaattttc acttgccaat aaaaaatgga 829201 gcttcgggcc cgtgcagcaa aaggagagtt tatcatgatt aagatcatca ttaccgacga 829261 tcaggatatc gtcagagaag ggctggcatc cctgctccag ctccgagaag agctcgatgt 829321 gatcgcaacg gcgcgaaacg gacaggaagc cttcgaaaag gcgaaagagc tggagccgga 829381 tatcgtgtta atggacatcc gcatgccggt ttccaacggg gtggagggaa caaaattaat 829441 cacaagctcg ctgccaagcg taaaggtttt gatgctgaca acctttaagg attcagcgct 829501 gattgctgaa gcgcttgaag agggagcaag cgggtatctg ctgaaggata tgtctgcaga 829561 tacgattgta aaagcagtga tgactgttca ttctggcgga atggtgcttc cgccggaatt 829621 gactgcccaa atgctgaatg aatggaagcg tgaaaaacag ctgaaaggaa taaatgagat 829681 agaaaaacct aacgagctgc tcgacctgac cgagcgcgaa atcgaagttc tggctgagct 829741 gggatacggg ctgaataaca aagaaattgc cgaaaagctt tacattacag aaggcacagt 829801 caaaaaccac gtttcaaata ttatcagcaa gctggctgtc agggacagaa cccaagccgc 829861 catttactcg gtcagatatg gtgtatctgt cttttgacat atgacgtttt gcatatacgc 829921 ttctctgaaa aggcctttta caggcctttt tttcatgccc tatgttctat ctgccgctac 829981 atgccgcacg cctttctttc ttctacaatg gcaatggatc aaaaaaagga gtgagacgac 830041 gtgctgcaag cagaaaacat caaaaaggca tacggaaaaa aaacaatcgt gaaaggcatt 830101 tctttttccc tcaaaaaggg ggagtcgttc ggtctgctcg ggcctaacgg tgcggggaaa 830161 tccacaacca tctcgatgat ttccggcctt gtgccgcatg acagcgggaa catcacggtg 830221 ggcggctatg ttatcggaaa agaaacggcc aaagcgaaac aaaaaatcgg cattgttccg 830281 caggaaattg cattatatcc gacgctgacg gctcatgaga atcttatgtt ttgggggaaa 830341 atgtacggac ttacgcacgg tgaggccaaa aaaagagcgg ctgaggtcct tgaatatgtc 830401 ggtctgactg agcgggctaa agataagatt gaaacatttt ccggggggat gaaacgaaga 830461 atcaacatcg gtgcggcttt aatgcataag cccgagctgc tgattatgga tgaaccgact 830521 gtcggtattg accctcaatc gagaaatcac attttagaaa cggtcaaaca gctcaacgaa 830581 acgggcatga cggtgatcta tacgagtcat tacatggaag aagttgagtt tttatgcgac 830641 cggatcggga taattgatca gggggaaatg attgcgattg gcacaaaaac tgatttgtgc 830701 agccgccttg ggggcgatac catcattcag ctcacggtca gcgggatcaa tgaagcgttt 830761 cttgtggcga tccgatctct ggcccatgtg aatgatgtaa cagtacatga attagagctc 830821 aaaattgaca tttctgcggc tcatcatgag aaagtcgtca caagcctgct tgctgaagcc 830881 actgctcatc atataaacct gctgtctctt caggtgcagg aaccgaatct ggagcgcctg 830941 tttctgaatc tgaccggccg cacgttgcgg gattgaggag ggacggcaat gaaaaaaagc 831001 atatggatcg catggaaaga tgtgaaaatc agaatcacgg acagaaaagg gtttatgatg 831061 cttatcctaa tgccgctcat cctaacctgt attttaggcg cagcgctcgg atcagttgtt 831121 gacggaggca gccggattga tgatatcaaa gtcggctaca ttcaatcaga ccagtcagat 831181 acagcaaaca tgtttacaaa agatgttctc aaaaaaatga agtcgataaa ggtcacaaaa 831241 gtcggcagca aagacaagat gaaaaaactg attgatgaaa agaaaatcga tgtaggcatc 831301 gttatcccga accattggga agccggcaaa acctcagctg ttgttaatgc cgctcctgat 831361 caaacattga aaagttccat cattgaaaca gctgcaagct catttataga gcaatataaa 831421 gcggtaaagg aagccgcgtc aggctcaatg gactacatca gtaaaacgga agctgtaaag 831481 caaggaaaac ttgaccctgc acagtttgca gaaaagctgg caaagacgct agaaaaagaa 831541 acaggtgaca agcttactat tgcggaaaaa tctgtcggca gcaaagccgt taccagtttt 831601 caatactatt cggcggcaat gctttgcatg tttatgctgt ttcatatcac agtcggggcg 831661 aaatcatttt tacaggaaaa ggatacggag acgcttgcca gaatgctgat gacgcctgcg 831721 caaaaatccg tcattctctt cggaaaatgg cttgggacgt atctgtttgc catcatacaa 831781 tttttcatat ttctgatcgt cacaatcaac gtatttggtg tggactgggg cggtaatctg 831841 ctgttagtga gtgtactcgg gctttcttac gccgcagctg tatctggtat ttcaatgctg 831901 cttgcgtcgt gcatcagcga tatgaaaact gcagatgcga taggcggctt cggcattcaa 831961 ttgcttgcgg ttctcggcgg gtccatgctg ccgctgtacc aatttccgga cgtcttgcag 832021 tctgtatcca aagcggtgcc aaatcgctgg gcgcttgacg gctttctttc tttaatggaa 832081 gggggaggct gggctgacct tcaaaagcct gtgcttcttt ttgcggcgat cggcttttgt 832141 tcacttgtaa ttggtatcag acggcttcat acaagataag gaggtacaaa aggtgaaaaa 832201 aattctagcc atttgcggca ttgagctttc tctcattttt aagaagccac agaactattt 832261 gatcatgttt gctgccccgc ttttgcttac ctttgtattt gggagtatgc tcagcggcaa 832321 tgatgataag gtgcggcttg caatcgttga tcaggacgat acgattctct cacagcatta 832381 tattcggcag ctgaaggcac acgatgatat gtatgtattc gaaaacatgt ctgaaagcaa 832441 agcgtcagaa aagctgaaac aaaagaaaat tgccgggatc atcgtcattt cccgctcgtt 832501 ccagacacag ctggaaaaag gcaaacatcc tgagctgatt ttccgtcacg gccctgagct 832561 gtcggaagcg ccgatggtca aacaatatgc agaaagcgca ttggcaacgc tcaatattca 832621 ggtgaccgcg gcaaaaacgg catctcagac agcgggagag aactggaagg cggcgtataa 832681 aacggttttc gccaaaaaac atgaagatat agttccggct gtaacacgac agacgctcag 832741 tgataaaaaa gagggtgcgg aagcaagtga cacagcctcc agagcagcag ggttttccat 832801 cctgtttgtc atgctgacca tgatgggagc ggctggaacc attttagaag caagaaaaaa 832861 cggcgtatgg tccagattgc ttacagcctc tgtcagccga gccgaaatcg gtgctgggta 832921 tgtgctgtcc ttctttgtca ttggctggat tcaatttgga atattgcttc tttccaccca 832981 ttggctgttt ggcatcaact gggggaatcc ggctgcagtt attgtattag tgtcactttt 833041 tctattgacc gttgtcggca ttggattgat gattgcggcc aacgtcagaa cgccagaaca 833101 gcagcttgcg ttcggcaact tgtttgtcat cgcaacatgt atggtgagcg ggatgtattg 833161 gccgatcgac attgaaccga aatttatgca atccatcgct gaatttcttc cgcaaaagtg 833221 ggcgatgagc gggttgacag agattatcgc taacggtgcc cgcgtcacag atattctcgg 833281 aatctgcggc attttgcttg catttgctgc gatcactttc gcagcggggc tgaaagcgct 833341 ccgagcctaa aaaacatctg ccgtttaggc agatgttttt ttgcatgtgg gtacattcgt 833401 atgggtgcag cctgaactgc ggttaatcct tatctatcat agctaaaatt gattccagcc 833461 aagaaacgta atttttctcc cgctccagcg ctttcgttag cacaagatag tggccgaagt 833521 ccggtgaaga aaatgacatc ggctctgctg aagccataag cttttcatag cttccctgta 833581 agtcagaaag cttggcctgg cgtttttgca gctggtcttt gaacaaatca gaagcctcct 833641 ggcgcgatag acaagaaatg aaataagcct tcagcataaa ttcatccttc accgtctcgg 833701 gtatcggctg gtggcggatc agccagtcat gcagctcctg ctttccgctg tctgtcaggg 833761 tgtacatctt tttctccagc tttgtgccct gaatcgttgt ccggaacgtg ataaatcctt 833821 catccgtcag ctttttgagc tcagggtaaa tctggctgtg cttggcgctc caaaactggc 833881 cgagctcctc tttaaaataa ctcgtaatat cgtatccact caattcgcct tttcgcaaaa 833941 gccctaatat ggcgtatttt aatactctca tgctatcctc cgtgtctggc tgtttcgcaa 834001 aacagatgag ccggtgctca actgtgattc taactgccta ttccccttat tatagaaaag 834061 ggaggaaggg aacacaaccg ggctctttgg aaatgaagat aaaaggtttg tcagaaggta 834121 tccgatttat ctccgtcaat ataaaagaga tttaaattta attttcagaa aaaatagtaa 834181 cgatattgat tttttatata taataggaaa ttggtggtat gaaaattttt tgggggaata 834241 aacgtgaaaa aagtacttat ggcattcatt atttgtttat cgctgattct atctgtttta 834301 gccgctccgc cgtctggcgc aaaagctgag tcagtacata atcctgtcgt tcttgttcat 834361 ggaataagtg gtgcatcata caactttttc gctattaaaa actacttaat ttctcaaggc 834421 tggcaaagca acaaactgta cgcaattgat ttttatgata aaacaggaaa caacctaaat 834481 aacggcccgc agcttgcttc atatgttgac cgtgttttaa aagagactgg ggcaaaaaaa 834541 gtagatattg tggctcatag tatgggaggc gccaatacgc tgtactatat taaatattta 834601 ggcgggggca ataagattca aaatgtcgta acgcttggag gggctaatgg tttagtgtca 834661 tcaaccgcgc tgccgggcac agaccctaat caaaagatcc tctatacatc tatttacagt 834721 ctcaatgatc aaattgtcat caatagcttg tctcggttac aaggagcgcg aaacatccag 834781 ctttatggca tcggtcatat tggcttgctt tctaatagcc aagtgaacgg ctatatcaaa 834841 gaagggctga atggcggagg cctcaataca aattaatatc ttcaaaaaac aacctgctgt 834901 ctccgttaca gtgggttttt tcgtctgaga aagccatagg gtcttatgac cttagtctat 834961 catgcatacg tcaatttatg acatcaggca ctttttcaaa tagagcggac atgttaaggt 835021 acaaccatcg atttctatca atttgaaata aaaggagcgc tgttatgcaa attaaagaaa 835081 tttttatgat ccgctgcatt tcgtgcttaa gtgtcgtctt gctccatatc atttcaatgg 835141 tcctgatgct tcaggcagaa gctcttgcag atatttctca cactgttgat tctttccgca 835201 cactcctgat gttcagcacg cccgctttta ttttcatctc tgaattttta ctggcccgtt 835261 cttatcctga tggggtgcct gacggttttt taaagaagcg gggaaaagtg atttttgttc 835321 cttttttatt tatcgcagcc atcgatgcgc tgctgatgac cagtgcgatg gggggagagg 835381 taacctttct cgcgtttgtg caaaaatatc tggcgaacgt attcttagga aactttatcg 835441 gatacttcat tctcgtcatc tttcaatttt acatgctgca tatgatgttt catgagtatt 835501 tgaaaaaagc atcgccgaaa tgggtgctgt ctatctcatt tgtggtgaca gccgcttatt 835561 taggctattt ctccgcagcc agcccggctc ctgcttctga agagggaggg gcatttccgt 835621 tcttctgggt tccgttcgca ggctggcttt tctacttttg tctagcctac tattgcggaa 835681 aagaatacaa gcgtttttta gcgctgctga accaataccg ctgggtggtg tacggcgccg 835741 caattgcttc tggggcgctg gttgtcactg tttcttatgt cggtgaaatc ggcatgatca 835801 gctcgaagcg gcctgatatc atgctgtatt caacaagcat gattttcctg tgttttcatt 835861 tgttttccaa aatgaagcat gtgccgaaaa tcatgatgtt tatcagcaac tattcctttt 835921 cgatttatct gcttcatgcc tattttatga ttataggcta cgtgttgctt ttgaatatgc 835981 ccgaaattcc tgccgtaccg gctgttctcc tgttgtttgc cgtgtgcaca gccggcccga 836041 ttatgacctc atgggcgctg aataagttca aatacgggta tttatttgtg gggaaaattt 836101 atcagccaaa acagaagaag gtaacagtcg aagtgcgtga tcacgcaggg tgaaaaacaa 836161 gcggcaggag ggctcctgcc gcgtttcttt acttctcatc cgcttgcaga actgttttta 836221 aatatagttt tgcagactca gcaagtccag atacatcagc cttttcttca tcgaaataca 836281 gggcgttttg aatgatgccg tcattcatat tgaggaaaaa cttggcgata gtcgcaagag 836341 gctgaaccgg ctgaaactct ccctgatcga tccctttttg caatagcctt gaaaaccttt 836401 ccacaaaaag atcatacctt ttctccaaat actgccgccg ttcttcattg cgccaagctg 836461 tcactaaata ttcaaattgc accggcgcca gcgtatctgc tacatctcgc aggccctcag 836521 tcagttcatc caaatagctg gaaatggagg cccaaacact ttggtgttca gctgatttat 836581 caagctttcg gagtccttca tccagccctg tttcaataat gcggcgaaac atctcctcag 836641 tgcttgaaaa ataaagatag acaccgcccc ggctgaaacc tgactcttct acaacatcct 836701 tcatcgtcgt taattcgaat ccttttcgtt taaaaaccgt tttggcagcc tctaaaatct 836761 ctgcctgccg tttatccttg tgctcctttg ttacttttgg tgacaagata tcgcctgctt 836821 tctgcaattt tcttacctat aagtgtaatc aacccaatca tgatcagcaa gcagccacag 836881 acaagaaaag caagtgatac accgatccat tccgccagca cgcccccgcc cgccatgccg 836941 aggatagagg cgagggttgt cgcactctga atagcgccga acaccctacc gctgtaatcg 837001 acaggcactg ttgtttgcac gagaatctga aatggaatat ggacgaggcc gaaagccgcc 837061 cccatgatga aaaaagcaaa tataaagaga gtgatgccgg caattcccat accgcttagg 837121 aatggcgcac ctccagttgc tagtccaaga agaagggttc cagctgagaa ataaagcaaa 837181 taagaagtga ttcgccgtct gccggtaatg gccgctgtaa ggagcatccc ggctccgctt 837241 acggccatgc accagcctgc cagctcgggc ggagctcctg aaaaggagcg gataagaata 837301 atcgcttggg aatcaccaat ctgcaaaaca aagagaacga cacaagctgt tagtaagcct 837361 gttaatagaa gcggcatccg tttcaaaaac tgaaggcctt ccttgataga agtaagtgct 837421 gctgtttttt cttgaggtgt attggctttt tgtaaaaaag catctctggg aaggaaaaac 837481 aaaatgacag cggaaagaaa gaaggcgccg gcgtttatat aaaaaacaga gtgtatcgag 837541 aaagcagcga tcagcgtgcc gccaagggca gggccgaaga tttttgagct gttatcaatg 837601 atgctgctga cggaaacggc ctgctgaatg tgtgcttccg gagccaattc cttaagcttt 837661 ccgtttttag caggtaaaaa aagtgaagaa aaacagctct gaacggatag caatacgtaa 837721 agctgccaaa gctcactgac ataaacgcag ctgataacag tgagggcacg gccgatttca 837781 gatagaaaca tgatcgtttt tctgtcaaaa cggtcggcaa gcagacccga tacaggtccg 837841 agtacaatga caggcaaagc aaacgacatc attaaaagcg acatatctaa tggagaagca 837901 tgaagctgaa aagcggctaa tgttagcacg gccaaaatgt gaagccagtc tccaagtgaa 837961 gaaatggttt gcgaggctaa cagtgtcatc agtccttttt gattgcgaaa caacggtttt 838021 tccatgattc atcctcctga ttattaaaat gacactagtg tcgtttttaa ttgtatggga 838081 aaaagacaca atatacaatc tttttcttgt aaaataaagg agaagattga atagaaggga 838141 gaacattcat gacatcagtc aatctaagct acccaatagg agaatacaag ccgagggaat 838201 ccatatcgaa ggagcaaaaa gataaatgga ttcaagtact tgaagaagtg ccggcaaaat 838261 tgaagcaagc tgtagaggtc atgacggaca gccagcttga cacaccgtac cgggacggtg 838321 gatggaccgt tcggcaagtt gttcatcatc tggctgacag tcatatgaac agctatattc 838381 gttttaaatt gagcttgacg gaagagacac cggctatccg tccgtatgat gaaaaagcat 838441 ggtcggagct aaaagactcg aaaacggcag atccgagcgg ctcactcgcg cttttgcagg 838501 agcttcacgg aagatggacg gctctgctcc gcaccctgac ggatcagcaa tttaagcgcg 838561 gattttatca ccctgataca aaggagatca ttaccctgga gaacgcgctc ggcctgtatg 838621 tctggcactc acatcaccat atcgctcata ttacggagct ttccagacgg atggggtggt 838681 cttaacgctt ttgccggcgg aaagccggaa tactgatagc agcaatcacc agaagtgaga 838741 ccacagcagc cgctgcatat aaatgatcat agccgctggc gacactcgca tgaatggcgt 838801 cgcttatcgc ggttttgact tcaggaacgg gaatgcgttc gatttgttct tgtaaagaag 838861 aaacttcaga actgtcgatc tccggaatca tctgcatcgc cttttctgaa tatccgctgt 838921 ccgataagcg gctgttgatc tcatcaccta tttggtcaaa cccggctgtg ataaaacctg 838981 cataaagagt aggcgccaag gtcagtccaa tttgccttac taatgaaagc gtgccaagag 839041 ctgtaccctt atttgttttt gccgcttctg atacaaggac gttcagcgga gcgcctaaca 839101 gaaagccaaa accgatccca gctgccacac ttgcgatcac aaactcccat ttttccgtga 839161 cccagagcgg aaataaagca aaccccgcac atgagatgat tcccgaaaga ataacggttt 839221 ttacaggacc ttttttgtcg gtaagtgctc cgccaagcca agcgccgatt ccggaagcca 839281 acgcaagcgg tgtcatccaa tagcctgctt ttgcggcagg gacacccaaa tactgttcga 839341 catatgacgg gataaaaatg actgccgcca agagcccccc ggataacaaa ccgatgataa 839401 gcgtgcgctg aaacatatgg tttcgcagca gagaatacgc caaaatggga tcgcctcctc 839461 gcatttcaac tctcttttca tacgagataa gcgctgcaaa acagagtatg ccaaaaataa 839521 tacatccata aacctccgga ttccccaagc tgtgtaagag atttgccccg tcaagattgg 839581 tcatgccgta catcacagct aaaatcgaca gggacaaaag gaagattccg gccgcatcga 839641 ggcgcttagc ctcaggtgct tttgtttccg cgataaaaca tgcgccgaaa acaaccaata 839701 gcacggcaat cggcaaatta atcaaaaata gccaatgcca agacccggtc caatcaagca 839761 gaaagcttcc gatatttggc ccgagcacag cggccatccc gttcattgcg ccaagcagcc 839821 caagcgcctt cccctgtttt tcctttggaa gggtcgcgag aatgtgagag ctgccgatga 839881 tgaaaatccc gccgcctcca agcgcctgaa tcagccgcga tatcagaaag agcgggaagc 839941 tttggctcaa agcaacaagc aaagaaccaa gtccgaacag gcaaacctca atgagaaaga 840001 gtttttttct gccgtagcgg tcggaaagtt ttccgacgat tggcacactg acgctaagac 840061 cgagcgtata aagggtaatg ccccatgatc cccaggaagg ggaaacggaa aacgactcgt 840121 ttatcgttgt taaagcagcc gaaataattc cgttatctaa agcagccata aacacgccaa 840181 tcgtaaacag gctgattgcc cacttttggc ttttctgctc tgttaatgct tcagacattt 840241 tcgtcaactc cttttagttc acttgaaata tattattcat tttaaatgaa ctaaatgtca 840301 aataaaaaaa gcctgctccc gcagtttgcg gatgacagac ttactgattt attctttttt 840361 cgcattctct aatgctcttg aaaggataga cagcccttcg taaacagcct gcttttcttc 840421 aggggacagc agctctaatg aacgcttcaa tttcaggtgg cccttttcat acaaaccccg 840481 gaaaatcttt ttcgcattct ctgtcaactg aacaactaca gagcggcggt cctcttcaga 840541 atgtgagcgt ttgacaaatc ctgatttttc aagccggtca agcagcccag ttgtattgga 840601 cagggaagcc cccatttttt cagcaatgtc gctcactttc aatgttccat ggttgtttaa 840661 tagcatcagc accttcattt gcggcatgct catatccagt ttcatccact cggacacatc 840721 accgagcccg gcggacgtta agactttcat atagagcacc catatttccc gttcctccga 840781 tgaaagaatg ttttcgttta agactgttgt atcgtgtaaa ttatattcca tttcatcact 840841 tcctcatcat tcactcctct taccatatta ctcgattttc actcctgaaa gaaagtgagc 840901 agaaaccgca tgcgggactt tgtccgaaaa ataacggtag tgtataatga gttggagatt 840961 attgggggag aggatcgaac tagaatatga ttggagagac cattgctgat taaaaagaat 841021 gctttatcaa tattaaaaat cgtttttcct attgctgttt tgctatttgt tatttatcaa 841081 tcgaaaaaag aactgacaaa tctgtcattc aaacgtacgc tcatggtcat caacggactg 841141 gaacgaacgg atttattcat gcttgtgttg atcggcttgc tggctgttgc ggctatgtcg 841201 ctgtatgatt acgtcctgaa gtactcactg cgcctatcga tcacaaacgg aaaagttttc 841261 agggtttcct ggatcgccaa ttcatttaat aatgtgttgg gattcggcgg tttagccgga 841321 gtcgggttaa gaatgatgtt ctataaggag catacgaaag accataaggc actcgtgaaa 841381 ggaatcgcct ggctcacatc atctatgctg ctcggattat ctgttttcag cattttcgtt 841441 gctgcgagag tgctgccagt tgatgaagtg attcatgaga agccttggct gtgggcggtc 841501 gttatcggtt ttgcactgat attgccgtta tctttagcgg tgtccaaaat aaaagaccgc 841561 aaagctgggg acgaagagaa tgcggataaa gtgaaaaatc cgattttcgc atatattgga 841621 gcttcagttg ttgaatggct catggccggg accgtcatct attttgcttt gttcgctatg 841681 ggcattcatg cagatatcag gtatgtgttc ggggtgttcg tcattgcggc gatcggagga 841741 atgatcagcc tcgtgccggg cggcttcggc tcgtttgacc ttttattttt gctggggatg 841801 gagcagcttg gctatcatca agaggccatc gttacttcta ttgtgttgta caggctcgcc 841861 tactcattta tcccatttat cttgggactg ttctttgccg ccggcgacct gacggaaaat 841921 acaatgaagc ggctcgaaac gaacccgcgc atcgcaccgg caattgagac gacaaacgtt 841981 ctgcttgttg ttcagcgtgc ggtattagtg agaattttgc aaggctcgct ttcccttatt 842041 gtgttcgtag caggtctgat tgtcttggcc tcagtttcct tgccgattga caggctgacg 842101 gttataccgc acattccgcg cccggcgctt ttgctgttca acggcctgtc cttaagctca 842161 gcgctcattc tgctcatttt gccgatcgag ctttataaac ggacaaaacg ttcctacacg 842221 atggccatta cagcgcttgt cggcggcttt gtgttcagct ttttaaaagg gcttaacatc 842281 agcgcgatat tcgtactgcc gatgattatc gtattgcttg tgctattgaa aaaacaattt 842341 gtccgcgaac aggcatccta tacactggga caattgatat tcgctgtggc gctgtttact 842401 gtggcgctct ttaactacaa tctgatcgcg ggctttattt gggaccggat gaagaaggtg 842461 ctgcgtcacg aatatttcgt ccacagcacc tcgcatatta cacatgcaac catcatggcg 842521 atcatcattg tgccgctgtt cttcttgata tttacagtgg tctatcataa gagaacgaaa 842581 ccgatcggag agaaagctga ccctgagcgt cttgctgcgt ttctcaatga aaaaggcggc 842641 aacgcgctga gccatcttgg ttttcttgga gataagcggt tttatttttc tagcgatgga 842701 aatgcactgc ttctgtttgg gaaaatcgcc agaaggctgg tcgtgctcgg cgatccatct 842761 ggccaaagag aatcattccc gctcgtgctg gaagaatttc tgaacgaagc gcatcagaag 842821 ggattcagtg ttttgttcta tcaaattgaa cgagaggaca tggcgctgta tcacgatttt 842881 ggctacaact tctttaaatt gggtgaggaa gcatatgtag atttaaatac atttaccttg 842941 actgggaaga aaaaagccgg ccttcgggca atcaataacc gctttgagcg ggaggagtat 843001 actttccatg tggatcatcc cccattttct gatgcgtttt tggaggagct gaagcaaatc 843061 tcagacgaat ggctcggctc gaaaaaagag aagggattct cgctcggatt ttttgatcct 843121 tcctatttac agaaagcgcc gatcgcctat atgaaaaatg cagaaggaga gatcgttgca 843181 ttcgcaaatg tcatgccgat gtaccaggaa ggagagatat cggtcgatct gatgcgctat 843241 cgcggcgacg ctccaaatgg cattatggac gcattgttta tccgtatgtt tttatgggca 843301 aaggaagagg gctgtacgtc atttaatatg gggatggcac ccttggccaa tgtcggcact 843361 gcctttacat ccttctggtc cgaaaggttt gccgctgtca tttttaataa tgtcagatac 843421 atgtacagtt tcagcggcct aagagccttt aaagaaaaat ataaaccgga gtggcgaggg 843481 aaatacttag cgtatcggaa aaacagatct ctttctgtca ccatgttcct cgttacacgt 843541 ctgattggca aaagcaaaaa agactccgtc taataagacg gagtcttttt ttatttcgtt 843601 tttaagaagt aggtttcaat atcatcaagc aggtagtttg cggctttaat tccgcctgcg 843661 gttgtccata cgacgtcatc gacttcatgt gcattacctg acttcacggc cttcaggttt 843721 ttccatagtg aactgcttgt ccactgattg gcccattttt cattttcttt tgcattatcg 843781 gctttataag tgaaataaaa cagcacatca gcatccatat caggaataga ttctttactg 843841 tcggttgaga acgtaaattg gtccttttgt ttcttaaaca gttccacttg tttttcaggg 843901 cgtttgaagc caagctggtc taaaataatc ccaggaaatg aatcggtata atagattctt 843961 gattcaccgg ataaaaagcg tacgactgaa acggttttgt ttgtctggtc gcccagcttg 844021 ttttttaaat cagaaacacg tttatcaaaa tcggcaatga cttccttgcc tttgtccgcc 844081 ttattcaccg cgttggcgta tagagtcagg ttatccttcc agttcccggc caaagattca 844141 gcaaaaacag tcggcgcaat cgcatttaac tgatcataaa ttttttcctg gcgcactttg 844201 tttccaataa tcaaatcagg ctttaattct gcgatggctt ccacattcgg ttccgtttca 844261 agaccgacgt ttttaacacc tttcatgtca tctttcagat agtcatacca cgggtcgccc 844321 ttccatgact ttacggctcc gaccggctta atgccaagcg ctaagagcgc ctctgttcct 844381 tcattagtta aaacaacaat ccgttttgga ttggcgggga tgttgtctga tgtccccatt 844441 gcatgtttga ccgttcttgt tttgctgctt gacacctcgc tgttgcttga actttctgaa 844501 ctattacagg cagaaagtac cataacggcc attaaaaata cgaatagcat gctgatatgc 844561 tttttcatct ttttcctccc aatattgaaa ttcattatca tttagatcat aataagcagt 844621 gttaagagtg tcaatcccta attgaggatt attctcaaaa acaaacatta catagtaaat 844681 aactaggaga attagatcat gatctgcaaa aaggcatctt caaaatggat tgtgttagta 844741 tgtctgattt tcattttact gacggctgtc tgcgcaagcg tcgtgtatgg ctatacaggt 844801 acgtcatgga gacaggtcta tcaggcgttt acttccttca atggaacaaa tgagcatgtc 844861 atcatcaagg atgtcaggct tccgcgcgct ttggttgcga cagtcgtcgg cgcctcgctt 844921 gcagccgcgg gcgctctcat gcaggcgctc acaaaaaatc cgcttgcgtc accggggatt 844981 ttcgggatta acgccggtgc aggttttttt attgttgccg gatcgttttt tctgcatatt 845041 cagtcacctc aggcattagt atggagctcg tttctggggg cagcatttac cgctgcgatc 845101 gtctatgcag caggctcgct tgggagggaa gggctgacgc caatcaaact gacgctggcg 845161 ggagctgcca tggcagccat gttttcttct ctgacacagg gcttgctgtc tgtcaacgaa 845221 ctcgagcttg cccaggtgct tttttggctg actggctctg tgcagggccg gagtctggat 845281 ctgttgatga cgatgtttcc atatgcagcg gcagcgctgg taatctgctt ctttctcggc 845341 caaaaaatta atctcctcgt tatgggagaa gatgtggcaa aaggactcgg ccaaaaaaca 845401 ggcctgctga aatttgtgat ggcgctttgt gttgtcatgc ttgcagggtc cgctgtcgcc 845461 attgccgggc cgatttcttt tatcggcatc attattccgc attttgcccg ctttgtcgtt 845521 ggtaatgatt atcgctgggt tctgccattt tccgctgttt tgggtgccat tttgcttgtt 845581 tgcgcggata tcggtgcgcg atatatcatt atgcctcagg aagttcctgt cggggtcatg 845641 accgccatca tcggaatgcc tgtgtttgtg tacatcgcaa gaaggggggc gaagctatga 845701 aacttcgttt tggcgttact gcggctgaaa agaaagcatg gatcgtcttt ttggttttac 845761 tggggttaac agctgctgta ctcatcataa gcgctggtct cggacaaagg tttattcctc 845821 cctgggatgt agcaaaaaca ttctttggtg caggttccaa gctggatgaa ctgatgatca 845881 tgtcgttccg catgccaaga attttgacgg ctttatgcgc cggtgtctgc ttggcagcgg 845941 caggcgcgat attgcagggg ctcgtcagaa accctctcgc atctccggat attatcggaa 846001 taacaggagg agcggcggta gcggtcgtgc ttttaatgat gttcttctca gaccgcagca 846061 gttcacttac gatcagtctg tcatggcttc cagcagccgc atttatcggc gcatcggctg 846121 tcgggctcat cgtctattta ctggcataca aaaatggcgc ctccacattt cggctggtgc 846181 ttatcggaat cggattttca atgtcggcgc aggcgatgac taccctgttg atgatcaaag 846241 gcccgattta ccgagcatca caagccaatg tgtatatcac tgggtcagtt tatgggtcaa 846301 actggcagca tgtaaaaata gctattatct tatctgtcat tctcttattc atttgttttg 846361 tcgcgctaaa aaatatgaat atacaggtgc tgggtgaaga tattgcggcg ggtgcaggaa 846421 gcgctgtgca gcgaaatcgt tttttcttgc tccttttgag tacggctctt actggttgtg 846481 cagtttcagt tgccggcaca atcggttttg tcgggctgat ggcgccccat attgcaagac 846541 ggcttgtcgg ctcatcttat ggcgcgctgc tcccagcgtc ggcacttatt ggagctctgc 846601 tcgttttaac agctgatatc gtcggcagaa ccttatttgc tccggtggaa gtgccggccg 846661 gcgtctttac agcggctatc ggcgcacctt attttattta tttgctctat aaaacaagaa 846721 attcttaatc gttacaccca ttttcttaaa aaagaaaatg ggtttttttg ataatgactg 846781 aagattcgta attatttttg ctatactgac agagacattg ataaagaaag ggcggcagat 846841 gaatgaaaga agcagaggta ttaaaatatg aagcatttac aagcagtccc ggcaaaggaa 846901 accccgcagg cgtcgttttg cagggagacg attatacgga agacgagatg cagatcatag 846961 ctgaacgtgc cgggtattca gaaacctcct ttatccgaaa aagcgagtcg gccgatcttg 847021 aactccgtta ctttacccct ggacacgaaa tgaatttgtg cggtcatgcg acagttgctt 847081 ctctttacgc attatgtgag aaaggaatgc tggagagcgg taaaacgtac agcatccaaa 847141 cgaaagcggg tatcctgcct gtgaagattt ctgaaaaaga tggccgcatt catatcacgc 847201 ttgaacaggc ctctccgcaa ttcaaaccat ttacaggcga tcggaaaaaa cttgcggacg 847261 cactgggtat caccgatgaa gattttcatg aagaccttcc gattgtgttt ggcagcactg 847321 ggatatggac agccatcgtt ccgcttaaat cattggaggc ttccaaaaaa atggtgccag 847381 ataacaaaca atttccggaa gtgttagttg atctgccaaa agcttcagtc catccgttta 847441 cctttgaaac cgtccatccc gacagcgacc tgcacgggcg ccacttttca tccccgtatt 847501 cgggaacgat tgaagacccc gtgaccggca cagcatccgg cgtgatgggg gcttatatga 847561 aacattatgg caatgccgag cagcataaat ttatcattga acaagggcag gaaattggaa 847621 aagacggaaa agtggagatc gaaatgaacg aagccggcgg ccatgtgaaa gtgaacatga 847681 caggaacagc cgtttactca gaaacccgta ttcttaaaat ctaatacgga tgatggttta 847741 caaaaagatg cactttccgt tatcattatg aaatgataat cattttcaat tgcataggaa 847801 ggtgagacgg tatgcctcaa accgaacaaa tacatcagca ttcagtactg agggacatca 847861 tacgcagcag aagatcgatt cgaaagttta aacaagagcc agtaccttca gcagtcattc 847921 ttgacatgct tgaaacggca aaatatgcgc caaatcacag agtgacagag ccatggagat 847981 ttatttacgt ttccagtgag acaggtaaag cgaacctcat taatacattt gcagcgttct 848041 ctaagaaatc caagccggat atgacagagg aaaagcttca aaatttcaaa aacacacttg 848101 ggcgcgttcc gggatttctc ctcgtcgtgt ttcaggaaga tgaaaacgaa agagcgcggg 848161 acgacgattt tgcggcaaca agctcgttga ttcaaaatct tcagcttctc gcttgggaaa 848221 aaggaatcgg catggtttgg aaaagcggaa aaatccttta tgacaaagaa gtccatcagg 848281 cctttggttt acaggataat gagcgtttcg ccgccatcat acaaacaggt tatcctgacg 848341 aggcgccgga agtgaaaaaa cgcacaccga tccgcgaccg attcactgaa atgtaaaaaa 848401 ccccttgtct caaacggaga caaggggttt ttcattaacg agatttcttt ttcgctctgt 848461 tgtcggctgc tttcgcacgc tcttgcgctt cgcggtcatc tgcatcagca agctcggttg 848521 aatattcttc gtaaacgccg tcagtttccc tttttaaggc atcgggaact tgtggaagct 848581 tttgtttgtt tttatcacgg tttttgtgga tatgatttct gcccatatca aattccccct 848641 aaaaagtgat atcaaacaaa tatagtattt ggttttaagg ggctatgtat tcctacttcc 848701 gcttagcagc tttttccgct tttttaaatt cgcctgaata aagaacttcc tgcatttttt 848761 tcaggttggc gccttgctgg tgcttctccc tctttttttc cataaaaagg acctccttca 848821 accatgttat tcttaaggtt gacgcttcct gctgttttta tacagtcttt cggtccgcta 848881 tcagctgtga gagtgcaaat tcaagatccg aatatgtaaa acgaaatcca gaggttatcg 848941 cttttttcgg aagagcgcgc tgtcctttca caatcaaaag actcatttca cccaatgctt 849001 ttgataaaaa gaattccggg acggggagcc agtgcgggcg gtgcttcacc cgtgcaatcg 849061 tttttccgaa ttgcttcatg tccacaggat tgggcgcggt gacattcatt gggcctgaga 849121 tgccggcgtt ttccaccgca tatcggatca tctgggccgc atcctcgaca tgaatccatg 849181 acagccactg ccttcccgtt ccgatcgttc cgccggccag aaacttatag gggagaatca 849241 tgagcgggag agcgcctttt tctccaagca tcacgccaaa tctcgcataa actgtccgga 849301 tgcccatcgc ttcaatatgc tgtccttcct tttcccacag gtgtgcagta tggctgagaa 849361 aatcctcatc tgacgttgca gaatcctctg tgaaagtttt ctcaaggctt gtgccgtaaa 849421 tgcccacggc actggcttgg atcaatgtct tcggcttctc cttctgtttc tgaataagcc 849481 gctgcacttc acgcgtcgca ttgatacggc tggagagaat gtgctgcttc gttttttctg 849541 tccagcggcc aaaaatcgat tttcccgcaa gatttatcca gacatcaata tgaggaagtt 849601 cctgctccgg tgcggctcct tccgacagcc attggacata tgtcatattt ttttgttcag 849661 tttcccttgc gtttcttgat aaaatataaa catggtgtcc ctggcgggta agaacgcctg 849721 tcagatgctg gccgagaaaa ccggttccgc ccgtcattgc gatattcatg aacatctctc 849781 ctcatcgttc taataaatat actttacctc attgtaataa aagaaaacgc gtttcaggcc 849841 tgagaaggga gattaagatg ccgtttatta caaaaatatc aacgcaaaaa aagaatacgg 849901 aacgcttcaa tatttttctg gatgataaat acgccttcag cgtggacgcg gatgtgctcg 849961 tgaaatttga gctcaagaag ggaaaagaac tcgatgatct tgacatcatt gagattcaat 850021 acggcgatga agtgaagaaa ggcttcaacc gtgcgcttga ctttttatcc tatcgaatgc 850081 ggtcgacgaa agaggtcgag gatcacttaa agaaaaaaga aacctcgccc cccgtcattg 850141 cggaagtcat ccataggctt aacgattaca agtacttaaa cgaccaggaa tttgccgcag 850201 cctatgtcag cactcacaaa aaaacaaacg gaaaaggccc tgatgttttg ttcagagagc 850261 taagagcgaa gggaattgat gacgatacaa ttaaggaggc gctaagttcc ttttcctttg 850321 aagatcagac aagagaagcg gtcaagcatg ttgaaaagct tctcaaaaaa gataaaaagc 850381 tttcgacgaa agaactcaaa cagcgcgccc agctgcagct tcagcgcaag ggcttctcat 850441 ttgatgttat cagcgcggcg atggatcaga ttgaatatga aaatgatgaa gacacagaga 850501 aagaagcgct gcgccttcac gcggaaaaag cgtttagaaa ataccgctat gacggctcat 850561 atgaaagcgc catgaaggtc aaacaatttt tattccgcaa aggattctca ctcgatttaa 850621 tcgagcaatt actgcaggaa gaggagtact gaaatggaga aacgatacag tcaaatgaca 850681 ccgcatgaac tcaataccga aatcgcatta ctttctgaaa aagcaagaaa agccgaacag 850741 catggaatca taaacgaact ggcagtgctc gaacggaaaa ttacgatggc aaaagcatat 850801 ttgctgaacc cggaagatta ctcaccggga gaaacatatc gtgtggaaaa cactgaggac 850861 gagtttacca tcagttattt aaatggcgtt ttcgcatggg gatacaggac ctcttcccct 850921 cagcaagagg aagcgctgcc aatctcagta ttgcaagaaa aagaataaag cgtaacagga 850981 ggctgatgat cagcctcttt ttgtttgcag cacatttaca cgaattctta aagaaaaaat 851041 cattgaattc acttgaaaaa tcttttaaga tgaaactcgt tgttttttaa aatcaaagga 851101 ggcgatgacg ttgagtatca aaaacccatc tgtaaaattt attatatttg ttcttatgat 851161 ttgtacattt tcaatcggct atacagaata cgcggtgatg ggtattttga cgtcgattgc 851221 caatgacttt catatacagg tttcatccgc agggcttctt gtcacggctt atgcggcaag 851281 cgtttgtttg acagggccgc tcgtcaccat catttccgtc aagcttccga gaaagcctgt 851341 gcttcttggg ctgatggcga tatttatcct ttccaacctg atgagcgcac tggcgccgaa 851401 ttttgcggta ttggccattt caagaatttt atctgcgtcc attcacggcg ctttcttcgc 851461 gattgccatg gtattcgcaa gtgaaatggt tccgccggaa aagcgtgctg cagctgctgc 851521 ttcaatgaac ggcggactga cagtggctct aatgcttggt gttccattcg gctcttatct 851581 cggagatgtc ctgaattgga gagcggtgtt ttccatcatt acggcacttg gtgtcatcgg 851641 atttttaggc cttatggctg ccgtgccgaa cagaaaacca aaagtgatcc caatgcttat 851701 gaatgagtgg ggtgttttta aacacaaaca agtgctgttt tccttcgcga ttaccatttt 851761 aggctattcc ggtgtcttta tcgcctacac ctttatcgaa cccattttga ggcattcagc 851821 cggattcagc acggttggca ttacaggtgc tctctttgcg tatggattgg gaggcgttgc 851881 cgggaatttc tttgctggaa aggtaccgct gcctttgctg actcggacga tgatcggcgt 851941 aatgatcggt ttaatcggtg ttctggctgt atttccttac atcgccattt acccggctgc 852001 agccattgtg gcaacgttcc tattcggggc atgcgcattc ggcacgccgc ctcttctgca 852061 aacaaaggtc atttcctcat ctgagggcgg cacaaccatt gccgcagctg tcagcgtatc 852121 agcatttaac cttgccaatg cccttggtgc atggatcggc ggaatgattt taaacggaac 852181 aggctcttat tcctggctgt ttgcaggagg tgcgcttatg accgcatgcg gacttgtgct 852241 ttctaccttc gcacacttat cagaaaagaa gagcgtctac gaatatcaag tcaataaagg 852301 gtaaaaaaca gctgcagtgt atgcagctgt tcttctttac cgtttgcctg aggctctcat 852361 tctttcttga ggatgctgat tgatagatcc gtcagcacgc tttgaagcat agtcgtcctt 852421 tgctctcggt tcaccctgaa atttgttttc gttttcgtaa ggaaatcctt tttctttatt 852481 tcggaccatg tcatatcccc ctaggttcga gatcaaaaag ttgcgtcttt tcagatgaag 852541 acgtaaggtt agtatatgga gaacaccacg taataaagcg ttattttttt cctgaagaaa 852601 ggagactgca cacatgaata tgtacattga gaaactgact aatctgcttc tggaaaagaa 852661 cgagatgatc agctatatac aggcaaaaac gtgggtggaa ttgttatgga gcgatttcga 852721 agcaacctac gcaaaagccg gacacgccta tcaaggtgaa aaaatgactg aaaaaatcgt 852781 cacacaatgg attgaaaact atggcggcca gctccacctt tttcaaagct cccgtaacga 852841 cgtgaatgat tacttaaatc aaagcagagg ccttttgcat taaaaacctg ccgttaacga 852901 ccggcaggtt ttttcatttt cttaaaatta ccttaacagg aagaaatcat aaacaaaaca 852961 tgtttcacca gcctgtcaat cagggaatac cacttatatc ttgtcaaaat gcgaggagga 853021 gctttatatg aaaaagaaac aagtaatgct cgctttaaca gctgccgcag gactgggttt 853081 gacagcactt cattccgctc ccgcagcaaa agctgcgccc cttcacgaca tatctgtcag 853141 catgccatca tccgatactt acatcataaa agcaggaaag ctgaatgtcc ggactgagcc 853201 aaatcatgaa ggtgatattc tcggcactgt atcatcagaa caaaaggtaa aagtcgatag 853261 gttcgtaaat gccgattggg ctcaaattca tttcaaagga aagaaagcat atatttcaac 853321 tcacttttta atgaaaaccg caagccaagc gaaaacaacg aaacagacag ccttctatac 853381 accgacgccc gaaaacggaa aagctaagca gctctcatct ggaacagagg tgacaatact 853441 tgggtgggga ttcagtgaaa acggcggatt tgacttcact tgggcgttcg tggattatgg 853501 cggagttaaa ggctatattc acacaaagga tttacaaatg cgataaaaag gcaggccgag 853561 gcttgtcttt ttgcctatgc atgaaacatt tcttctttct gcacgtaaca atgagaaagg 853621 agatgatgat atgacgggtt tagtcggcgg agggcttatg atcattgcgg gcatactgat 853681 caaactgttt cctcccaaat cgatcaacag tgtgtacgga tacagaacga gacgctcaat 853741 gtcagatcaa agattatgga atgaagcgaa ccgttacagt gcatcattaa tgatcctgtc 853801 aggcttggtg attgcgggaa tgggtttgct gctgggatca aacttgttta ttcttcagct 853861 tatcctgctg attgccgcct gtgtcataac atttatgcta acggagaaaa ggctgaaaat 853921 catgacgcac agtcaaggag gagatagaag tggacggagt taaatgccag tttgtcaata 853981 cgaacggaat cacgcttcac gttgcagccg caggacggga agatggcccg ttaattgtcc 854041 tgctccatgg atttcctgag ttttggtacg gctggaaaaa tcaaatcaaa ccgcttgttg 854101 atgcgggtta ccgggtcatt gctcctgatc agcggggcta caatctcagt gacaaaccgg 854161 aaggaattga ttcgtatcgg attgatacat taagagatga tatcatcggg cttattacgc 854221 aattcactga tgaaaaagca attgtcatcg gtcatgactg gggaggagct gtcgcatggc 854281 atttggcttc cacacgcccg gaatatcttg aaaaactgat cgcgatcaat atcccgcacc 854341 cgcacgtcat gaaaaccgta acgccgcttt atccgccgca atggctgaaa agctcgtata 854401 tcgcatactt ccagctgccc gatataccgg aggcatcact aagggaaaat gattatgata 854461 cattagacaa agcgattgga ttatccgacc gtcccgcgct ttttacatcc gaggatgtca 854521 gcaggtacaa agaagcgtgg aagcagccgg gcgcgctgac agctatgctg aactggtaca 854581 gagccctcag aaaaggaagc ttggcagaga aaccctctta cgaaacagta ccttaccgaa 854641 tgatctgggg aatggaagac cgctttttga gcagaaagct tgcgaaagag acggaaaggc 854701 attgcccgaa tggacatctc atctttgttg atgaagcttc ccattggatt aaccacgaaa 854761 agccagccat cgtcaatcag ctgattttgg aatatcttaa gaaccaataa gctaaaattt 854821 ctctccatcc gtctgtcata atggcagact ttttctgtgc gttttttttc atagtctgtt 854881 ttaaacatga caaaataaca ttaaaaatca tgaatgtcac cataaaattg taacaaaaaa 854941 caggtttaaa cgactttaaa aaaaggaata gccttactga agatttgtgt aaaactcccc 855001 taaggcaata cttaaaaaga ataataaaaa gaaggtgcct taatgaagca aggattaatc 855061 tcgattatta tcccgtctta caatgaaggg tataatgtta aactcattca tgaatcttta 855121 aaaaaggaat ttaaaaacat tcattatgac tatgaaatat tcttcataaa cgacggaagt 855181 gttgatgaca cgcttcagca gatcaaagac ttggcagcga cgtgcagccg ggtaaaatat 855241 atatcttttt ctcgaaactt tggaaaagaa gccgcaattt tggcgggctt tgagcatgtt 855301 cagggcgagg cggttattgt catggatgcc gatctgcagc atccgacata tttgctgaag 855361 gaatttatca aaggctacga agaagggtat gaccaagtca ttgcccaaag gaacagaaaa 855421 ggggacagct ttgtccgctc actcttatca tctatgtatt acaagttcat taataaagcg 855481 gtggaagtcg atttgcgtga cggtgtcggt gacttcagat tgttaagccg ccaagctgtg 855541 aatgcacttt tgaagctgag cgaaggaaac cgcttctcaa aaggcctttt ttgctggatt 855601 ggctttgatc agaaaattgt attttatgaa aatgtcgaac gaaaaaacgg cacctccaaa 855661 tggtcgttca gcagtctgtt taactacgga atggacggcg tcgtttcatt taatcataag 855721 ccgctgagat tatgttttta tacaggcatt ttcatcctgc tgctttccat catttatatc 855781 attgccacat tcgttaaaat tctgactaac ggtatttctg tgcctgggta tttcaccatt 855841 atctcagcag tgttatttct cggcggagta cagctgttaa gtcttggaat aataggtgaa 855901 tatatcggcc gaatctatta tgaaacaaaa aaacgcccgc attatttgat caaagaggcg 855961 aatatcccga acaaagacct gcctgaaacg aacgaattaa aaagcatgcg gcgtctgaca 856021 aaaatgcact gaaaatacca agcgccattg gcagtgcttt ttttgcgtgt ctattatctt 856081 aaaagcaaga ctggagaatt catatgaaaa gaaaacatat catgatctat gcggccagtt 856141 tgctggtgtc cgttctggca cacgcttttt ttgtgaaaga atgggcggaa ggcaggtata 856201 tgacaggtcc gggtgacggg cttgcgcaaa tgatcgtatt taaaaaatta ttatttgacc 856261 aatatacaca cgggaatttt ttctacaatt attcattcgg acttggcggc ggcacattca 856321 gtcagctcgg ctattatttt tctgcgtctt ttctttttct tgctgtgtct gccgctgttt 856381 ggctgcttca agccgtccag ctgatcggag aaacggatac gcttttttgg gcagagtcag 856441 ctgtttttat cagtattttc aaattgagct tgatcatctt tacgtccgct tctgtttttc 856501 attatcttct taagcacagg gcggcatcgt tcacgggagc cgtgttatac ggcgtctcaa 856561 ttatttattt ccgtcacgaa gcgtattggg aatttttcac cgatacaatg gtttggcttc 856621 cgctgcttgt gcttggcgca gaaaaaatta ttagagagcg gcgtccggcg tggtttatcg 856681 ttgcgtgttc gctgacgtta atcaacaatt tttactttgc atacataaac cttatattca 856741 tcggaatcta tgtgctgttc agatggctga tccgtttgga accacatgaa gagaaaagat 856801 ggattcaaat cagattattt ctcgtttcag gcttcatttc ttttggcatc agtgcggcgg 856861 cgtttgtgcc ggtagtatac ggttttttaa acaacctgcg ccctccatac agccagaaaa 856921 tagagtggct caatttcgat gataatatct tattttcgag ccggatcatc attgtgccgg 856981 ccgcttttct gctgtttttg tttattattt ctttttacaa aaaccgtgtg tttcgtctct 857041 ttgccgggtt gagcctgctg tttattctgt ttcatttcag tccgtatgcg gcaagcgtct 857101 ttaacggttt ttccgccccg caaaaccggt ttgaatatgt tctggccttt accattgcgg 857161 gagcagctgc ggctggtttg tcacagctgt ctgaattgaa acggaaagaa ctgctcccgg 857221 ccgcagctgt cgtcctgctt ctttacttgt atcatatcca aaggtataag ctcgatatat 857281 ggaagcctgc gaatgaaagt attctattgc tcttactcat gacaatcgca gccttgtttg 857341 ctgcagcttt tgcgaaaaaa cgggcaaaaa tggctgtgta cggtataatc attctttctt 857401 cgctgtttgt cgccaactcc tatcaaaaat acgcgctctc agaaggcggc gatttggaca 857461 gtgtgacaaa agaatatctt acaagtgagg aatacagagg gcgggaatca tctgagctca 857521 tcagacgttt acagaaggaa gacgatgacc cgctcatgag aatcgactgg atgaacgggg 857581 tccgcaataa tacgccaatc atttacggat ttaatggctt cagcgcgtat tccagcattt 857641 taaacaaaga tctgctggcc ttctattgga atgatttaag catcgatatg ggcagggaaa 857701 gcgtcagccg ttacgcgtca ttgggagaca gggcgaattt atacagcctg ctttacggca 857761 aatattatat gaccgaaaaa acaaacgaag ccagcgtccc gtacggcttc aaaaagcatt 857821 tagaaacaga gcattatgca gtttatgaga atcagtacat gcttccattc gttaaaacag 857881 cggatgccat atacagcgaa agtgagctgg accgattgcc cgctcttgcg aaagaacagg 857941 cgatgctgaa aggaattata ttaaaagatc catcaggaaa aacggagcag acaccaaaac 858001 cgtccaattt gatcaccaag tcggacatca ccgcaaaaca agcccagtat caaaacgggc 858061 tgctaaccgt aactggagaa aacggaggag agctgatcat caccccgaaa cagccatcat 858121 ccgctccggg agactactat gtcagctttt atttgaaaag caaagcaaaa gacaaaggat 858181 ttacattaaa ggtaaatgat tatgtcacaa caaggaaatc gaacaaatcg atctataaaa 858241 ccggagtaaa taatataacg gtaagagtgc ctaaatcagg ccatatctca atcaatcttc 858301 cgaaaggaac ctatgagctg agaaacatag cgctctatga agaaaattac caaacgctga 858361 aaaacgctgt aatgcaaaat aaaacagaga aagcagacaa actgaattgg aacaaaaatc 858421 gactgacctt ttcctatcat ctgtcaaaag accagtacat catgcttccg atcccatatg 858481 aaaaaggctg ggagctgaag atcaacggaa aaacacagaa gatcgaaaaa gcggattatg 858541 cttttatagg cttcaaggcg caaaagggag acaatcacat tgagctgact tactatccgc 858601 catacttcaa aatatcggcg atcatatctc tcgtcagtct gctgcttgct gttttttata 858661 taagacgtaa aaagcccggc tctatataga gccgagcttt aattttttct gaagtttttc 858721 ttcgctgaat atccatcccg tataggatga acgaatcgtg agatcatggc cgatatgaac 858781 aattgcgaca aacggataat ggcctttgct ccgataacgc aggtcgataa atctcacctc 858841 ataatgatct ttaaacgtat ccacttccca ccggtatacc ggagaaaagg acagaaacgc 858901 cgcgatgtta tcatcctgct ttgccgcatg cattacatcg gtttcaggaa caggcacccg 858961 attaaatgta tccagaatca cgacatgtcc ttccatgctt cttcctacat agaaagcatg 859021 tgctgtcgtc actgcgattc gccattgcct gaatttcatc gttggagaaa taataatgct 859081 ttcgatctca tcatgaatca tctcatgaag cttccgttta attctcagct gcatgatcag 859141 gcgcaccaag tagtagccta ccaatatgat atataagctg agaaacgtga tgccgggact 859201 cccgcctgca taccaaatcg cgatagctgc cagatggctg ataaaaataa acggatcaaa 859261 cgtattaatc agcccgagcg caacccattt tttcgaaaac ggacgaatgg cttgtgttcc 859321 ataggcgttg aatatatcaa caaagacatg cagaacgact gccagcagtg tccacagcca 859381 caggtgcaga aaatcggcct gaggataaaa taaatacaga atcgccggga tgatgacaga 859441 ccaaaacaaa acggcgggaa ttgaatgggt aaatcctctg tgattcctta tataaacagc 859501 attgttttta agctttaaca cagtatcaat atccggagcc tgagagcccg caagcgttgc 859561 gatcataaca gcgtgagcca ttgccggatc tgatccgaca acaggatcaa gcgtcgcaat 859621 accgcccagt gcgatgccca taacgacatg tgtgcccgta tccataggtg acctccttgc 859681 agggtgatcc tgcacattca ctttgtaaga aattccccat tttcatatac ccaattttta 859741 aactgattca atcgttctca tatgtttccg ctttttcttt attactattt aatgtaacat 859801 attatcgtac tgtgccctta gtgtacaaca aaaaacagtc taaagaaaag cggggcgcga 859861 aagactgggg agaaacacat atgaacgtac ttgaagacaa attaaaacaa aaagacatac 859921 agcaatttcg cgatgattta atctcatggt ttgaacgaga gcagcgcgtt ttgccgtgga 859981 gagaggacca agatccatat aaggtgtggg tatctgaagt gatgctgcag caaacgagag 860041 tagagacagt gattccttac tttctccggt ttgtagaaca attcccgaca gtggaagcgc 860101 tcgctgatgc tgatgaagaa aaggtgctga aagcatggga agggctcggc tattattcgc 860161 gagtcagaaa cctgcaaagc gcggtaaaag aagtgaaaca ggaatacggc ggcattgttc 860221 ctccagacga gaaagatttt ggcgggttaa aaggcgtcgg cccttataca aagggagcgg 860281 tgctcagcat tgcctacaat aaacccattc ccgcggttga cggaaatgtg atgcgtgtca 860341 tgtccaggat tctatctatt tgggatgata ttgccaaacc aaaaacaaga acgatctttg 860401 aagacgccat acgagctttt atttccaaag aaaaaccatc tgaatttaat cagggcttga 860461 tggagcttgg agccttgatc tgtacgccaa aatcaccctc atgcctgctt tgcccggttc 860521 agcagcattg ctcagcattt gaagaaggca ctgaacggga gcttccggta aaaagcaaaa 860581 agaaaaagcc cgggatcaaa accatggccg cgatcgtact gactgatgaa gacggacaag 860641 tgtatatcca caaacggccg tctaaaggtt tgctcgccaa cctgtgggaa ttcccgaatc 860701 ttgaaacaca aaaagggatc aaaactgagc gtgaacagct cattgctttc ttagaaaacg 860761 aatatggcat acaagctgat atcagtgatc tgcaaggtgt agtcgagcat gttttcaccc 860821 acctggtatg gaatatttca gtgtttttcg gtaaagtaaa acaagtgtcg gataccagca 860881 agctgaaaaa agtaacgaaa gaagagctcg aacaatttgc gttcccggtg tcacatcaaa 860941 aaatctggaa gatggcagga gaagcagccg ccatctcggc tgctccgtaa accattctta 861001 atcgtaagag acgcgcgtgc cgtggctgta gtccgcttca ttgcgcttca ttccgccgcg 861061 cgcttcaatt tcttgcgtta attcccggta ttttgattgg ccttcttcgt tcaaataagg 861121 cataatttgc tgaaaggcat gatgaaaata agcgagttca ctgttcttcc aatctttttt 861181 ggaaaccatg ttcaattcgc tcatatcacg tccgacatac ataacagaag acccccttta 861241 aagttcttgc cattattgtt tgtggaaata aaagaactat acgctacaag gagatgagga 861301 aaaatggaac aaaataaatg tgcactcgta acaggaagca gccgcggtgt cggaaaagcg 861361 gccgcgatca gacttgctga gaacggctat aacatcgtca ttaactatgc acgcagcaaa 861421 aaagcagcat tagaaacagc ggaagaaatc gaaaagcttg gcgttaaagt gcttgtcgta 861481 aaagcaaacg taggacagcc tgcaaaaatc aaagaaatgt ttcagcaaat tgatgaaacg 861541 ttcggcagac ttgatgtttt tgtcaataat gccgcttcag gagtactaag acctgtcatg 861601 gaattagaag aaacacactg ggactggacg atgaacatta atgcgaaagc attgcttttc 861661 tgcgctcagg aagctgccaa gctaatggag aagaacggtg gcgggcatat tgtcagcatt 861721 agttcattag gctctatccg ctatcttgaa aactacacca cggtcggtgt atcaaaagca 861781 gcgttagagg ctttaacccg ttatcttgcc gttgagcttt caccaaaaca aattatcgtc 861841 aatgctgttt caggcggagc gatcgacaca gatgcgctga agcacttccc gaatagagaa 861901 gatctgcttg aggatgcgcg ccaaaatacg ccggcgggac gcatggtcga aattaaagac 861961 atggttgata ctgtggagtt tctagtgtct tccaaggctg acatgatccg cggacagaca 862021 attatcgttg acggcggacg ctcactgctc gtttaaaaat ttttaaaaaa gaggaatagc 862081 tatacgatca cctgcacatt ctaatgaccg tggaggtgat aacaatggct aactcaaata 862141 acttcagcaa aacaaacgct caacaagtta gaaaacaaaa ccaacaatca gctgctggtc 862201 aaggtcaatt tggcactgaa tttgctagcg aaacaaacgc tcagcaagtc agaaaacaaa 862261 accagcaatc agctggacaa caaggtcaat tcggcactga attcgctagt gaaactgacg 862321 cacagcaggt aagacagcaa aaccaatctg ctgaacaaaa caaacaacaa aacagctaat 862381 cactgaaaca gaaaaaagca cttcatcttc gggtggaagt gcttttttct gtttgaaaaa 862441 cgacaaaact tgtggaaggt ctacagaatg agtcaaaggg tttgctttat ggagatcgaa 862501 atgattaaag gaggaaatgt ttatactttc atcaggctga aggaggaacc gatgaccgaa 862561 tttgaaaagc tggtaagtga acagatgaaa acgatggata agcttctcga tctccaatca 862621 gagctcgacc gctgcaaaca aattgaggcg gaactccggc atttggaaag ggatgcaagg 862681 ctgcgtggga ttcaggctga aattgcggta aaacggaaac accttgccga tatacaggat 862741 atgtttcaaa agcagacaga gcaggtcatt cgttcatatc gcagctcaga aaagccgtct 862801 tcctttgtgt agtgcaggaa tgtgccattc cccggccgga atggctcttt tattttcatt 862861 tttcaatttg taacgttata ataggtaaaa gacgttgtcg gtaagcaaat ttggacatac 862921 taactgtagg gctttataga aagtagggga gaaatatggg ctatcccaag gaaggagaaa 862981 ccattcaaat tcacagctat aagcacaacg ggctgattca tagaatttgg aatgagacaa 863041 caatcttaaa aagtacagaa atgtgtgtca tcggagccaa tgaccggacg atggtaaccg 863101 aatcagacgg ccggacatgg ataaccagag agcccgcaat ctgttatttt cacgcaagac 863161 aatggtttaa tgtcatcggg atgctgaggg aagacggggt tcattattat tgcaacatca 863221 gttctccgtt tgcctatgat ggcgaagcaa ttaaatatat tgattatgac ttagatgtta 863281 aggtttttcc tgacatgacc tacaatattc tcgatgaaga cgaatatgat gatcatcgga 863341 aagccatgaa ttatccaaaa gaaatcgaca gtattttaag agactactta aatacgctgc 863401 tccattggat tcaccagcgt cagggaccgt ttgcgcccga gtttgtcgat atgtggtatg 863461 aacggtattt gcgctataca aaataatggt tacgtaaaaa cctgttgcgg ggtacaacag 863521 gtttttcaca tgggctcaca cacatcatga taaagagaga gggggaatca accgtggggg 863581 ttatgaaacg ctacatgcaa ttcgtcaaac cttataagaa gcaaattttc gttacagtgt 863641 taatcgggat cgtaaaattc tccattccgc ttgctctccc attgcttctg aagtacgtag 863701 ttgacgacat tattcaagga ggcggcacgg ccagtgacaa aaccacgtca ttgttcacga 863761 ttatggcgat catgttcgcc ttatttttaa ttttgcgccc gcctgttgaa tattaccggc 863821 aatattttgc ccagtggact gccagcaagg tgctttatga tataagagct aagctgtttg 863881 accatataca aaaactgagc cttcgttttt acgcgaatac aagaacaggg gaagtcattt 863941 cccgagtgat taatgatgta gaacaaacaa aggatttcgt catcacaggg ctgatgaata 864001 tatggctcga tatgctgacg attttgattg taatctctat catgctcaca ctggacgtta 864061 aattaacgct gatctctatc gttttattcc cattatacgg aatatcagtg aagtattttt 864121 acggccgttt acgaaagctg acaagggagc gctcacaggc tcttgctcaa gtgcaggggc 864181 atttgcatga acgcattcaa ggcatgcctg tcatcagaag ctttgcgata gaagatcatg 864241 aacaggctca atttaatgag aaaaacggtc atttcttaga taaagccatc cgccacacga 864301 attggaacgc gaaaaccttt gcggtcgtta ataccattac agatttggcg ccgctcatcg 864361 tcatagcgtg cgccgggtat tttgtcatta atggaccgct gacagtcgga acaatggtcg 864421 cgtttgtcgg atatattgac agaatgtaca accctgttag aaggctgatc aattcctcta 864481 caactttgac acagtcaatc gcatcaatgg acagggtgtt tgaatttatt gacgagccct 864541 atgaactcac tgacaaacca aatgcgataa aggccgatca gattcgcgga ggagtggagt 864601 ttcaaaacgt ttcgtttcaa tatgagaagg acaaagaaaa tattcttcat gatgtatcct 864661 taaaagtaaa tagaggagaa actgtagctc tcgtcggcat gagcggagga ggaaaatcaa 864721 cgctcgtcag cctgatccca agattttatg atgtaacaag cggcagactg ctgattgatg 864781 ggacggatat tcgcgattat gaagcaagaa gccttcgcaa ccaggttggt atggtgcttc 864841 aagatacctt tttatttagt gaaacgattc gggaaaatat cgcgatcggc aagcctgatg 864901 ccacacttga agagataatc gaagccgcca aagctgcaaa tgcccatgaa tttatcatga 864961 gttttccaga aggatatgag acccgggtgg gggaacgagg cgttaagctt tcaggcggac 865021 aaaagcagcg gatctcaatt gcgcgggtat tcctgaaaaa tccgccgctc ctcattttag 865081 atgaagctac atcagctctg gatttggaaa gtgagcatta cattcaagaa gcgatggaca 865141 aactggcgaa ggatagaaca acttttgttg tcgcccaccg tttatcgaca atcacccatg 865201 cggataagat tgttgtcatg gaaaacggga caatcattga aatcggaacc catgatgaac 865261 tcatggacta tgagagccaa tacaagcact tatttaccat tcaaaatttg aactaaaaca 865321 tcaatcttat atccttttaa cgaaggatat aagatttttt tgtatataaa aaaacccggc 865381 tgtttaaccg ggttactctt ctgtttctat ttcgcagtct ttcggatgat acgtttgaaa 865441 acttgtgata agtgtttcta aatgttcaag ctgctcgcga tattccacgg cgcttgccat 865501 aatattgagc atgttgtaat caataagctc ctcatccgta ttctgctgat tttttaaaaa 865561 tgactttgtt aaaagctgct tataccggat gccttcttca accgcgtcat catgcggctt 865621 gatttttccg acaaacctca tcaaaatccg ctcgtgccag taaagcaggt aatcaagttc 865681 ttcagtcaat gtttcctgaa actcttccgg catatgatag atctcgtttt ccagacgatg 865741 cagcttcttc aatgtatcaa gcgcccgatt tgcagtaata atggcctgtc tgaacaggac 865801 aagctttctt gatttcacat aagtcgtttt cttaaagtaa cttctttctt ctttatatag 865861 aagatatgtc tgatcaagct tgatcatttt ttctttcagt ttttcaatat cctctttcaa 865921 aatcgaatgc tctgtcgact gccgcatgga caatctgatc cacttcataa tttcttcggt 865981 gttttcgacg gtattatgaa tcagctttgt ttcgtactta ggaggcaaaa acacaaggtt 866041 gacgataaag gaagaaagca cccctaagat gactgtgctt gttctgatca gcgcgaacat 866101 taaaaagtcg tcaccggcag attctaatat cgcaatgact gttacaagag caattgaaat 866161 tgtatgttca attttaagtt tcagcatgat tgtaatgaca ataactgctg ttaacccgat 866221 cataatcggg ctgggtccga aaataaggcc gaacactgtg gcaatcacag ctccgatgat 866281 atttgcttga acctggtcaa taataatgag aaaagagcgg taaatcgacg gctggatcgc 866341 aaatatcgct gcaattccag cgaaaatcgg cgcgggaagc ccgatccacg aagccaaata 866401 aagggcaagt gtaatcgcaa tcccggtttt gaaaatgcgg gcaccaagtt tcattggttt 866461 gtgcgtgcat tcctttctat agtaaattgt gtgacatagc aaatgggcta atccttaaaa 866521 ttcccggtta gtttatttgc taaacaatta agtaatatac agggatcgat acaaatattc 866581 aagctatttt tctagaaaaa gaccaaaatc ttacacgctg tttgattcca taaaaaaaca 866641 ggagctcaaa gctcctgttc aaggtatttg attctagttt tttagatgtt taaatgcatc 866701 ctcgaccgct gtaagcgtgt ctttaatatc ctgctctgta tgtgctgtgg taataaacca 866761 agcttcatac ttagaaggtg ctaaattaat tccgcgttcc agcatcagct tgaaaaacgt 866821 agagaatgtt tctccgtcac tccgttcagc ctgctcgtaa ttttccactt tctcatcaga 866881 gaagtatacc gtgagcgcac cttttaaccg gttgaccgta atggtgatgc cgtgtgtttc 866941 tgcgtgcttc aaaatgcctt cctcaagcat agcgccaagg tgatcaagct tttcatacac 867001 gcctttttct ttgagcactt ccagacaagc gatgcctgat aggatggaag cggggttccc 867061 tgccattgtt cctgcctgat aagcaggccc tagcggagct acctgctcca tgatttcttg 867121 tttgccgcca taggccccaa tcggaagtcc gccgccgata attttcccga gtgctgttaa 867181 atctggtttc acctgtaaga gatcctgcgc gccgccatac ataaagcgga aagccgtaat 867241 gacttcatcg taaataacga gagcccctgc attatgtgtt aattcattta cttgttctaa 867301 gaagccctct ttcggctcca cgataccgaa gttgccgaca atcggttcaa cgagaaccgc 867361 cgcgatttca ctgccccatt tttcaagagc tgctttatag ctatcgatat cattaaatgg 867421 tactgtgatc acttcgtttg caatgctttt cggtacaccg gctgagtctg gtgtgccgag 867481 agtagacggg ccggagcctg cggcgacaag cacaaggtcc gaatgcccgt gatagcagcc 867541 cgcaaattta atgatttttg tccggcctgt atatgcgcga gccacgcgga tggtcgtcat 867601 aacggcttct gtacccgaat tgacgaatct tactttgtcc atagcgggaa tggcttcttt 867661 gagcattttt gcaaatgtaa cctcgtgttt cgttggtgtt ccatacaata caccgttctc 867721 tgctgctttt ttaatcgctt ctgtaatatg cggatgggca tgtcctgtaa taatcggacc 867781 gtacgccgct aaataatcga tgtatttgtt gccgtccaca tcccaaaaat aagcgccgct 867841 tgctttctcc attgcaacag gagaaccgcc gccgactgct ttatatgatc tagacgggct 867901 gtttacaccg ccgacaatgt gctgtaatgc ctcattgtga agttcaattg attttgtatg 867961 caagaataaa aacctcctat atctccatgc gtcctttcta ttgtagcatg cttccgaaca 868021 agaacaatgg cttcgggctt cagattcagc tgagatggtt gtaatctgga caagaattgg 868081 atacgcttaa taaaaaaaca tccggaggta acgtaatgac tatagaaatc ggacaaaaag 868141 cgcctgatct tgagttaaaa ggtgatcatg gggaaacagt aaaattatcg gattataaag 868201 gaaagtacat cgtgctttat ttttatccaa aggacatgac accgggatgt acaactgaag 868261 catgcgattt tcgggacagt cacgaaagct tcgccgaact ggatgccgtc attatcggcg 868321 tcagcccgga cagccaggaa aaacacggaa aatttaaaga gaagcataac cttccatttc 868381 tgcttcttgt tgatgacgag cataagctgg cggaagcatt tgatgtgtgg aagctgaaga 868441 aaaacttcgg aaaagagtat atgggaatcg agcgttccac ttttttaatt gataaagaag 868501 gccggctcat taaagaatgg agaaaagtaa aagtaaagga ccatgtagcc gaagcgcttc 868561 aaaccctcaa agatatgtct gaaaagtaaa tctctatgag cctatgctta cttttaccct 868621 gatatcaatt gacaaattat cgtagaaaga gttacactaa ttataaacat tacaatgtaa 868681 gaattttttt tagaagagag gtgcatgacg gatggctgca catgaactaa aagaagcctt 868741 agaaacgttg aaggaaaccg gagttcgcat tactcctcaa cgtcatgcga ttctggaata 868801 tctcgttaac tctatggctc atccaacagc ggacgatata tataaagctc tggaagggaa 868861 atttcctaac atgagcgtag cgacggtata taacaatttg cgtgtgttcc gggaatcagg 868921 tttggtaaaa gagctcacat acggtgatgc ttccagcaga ttcgattttg tcacatccga 868981 tcactatcac gcgatttgcg aaaactgcgg taaaattgtg gacttccact acccgggcct 869041 tgatgaagtg gagcagctcg ctgcccacgt cacgggcttc aaggtaagcc accaccgttt 869101 agaaatttac ggcgtctgcc aagagtgttc gaaaaaagaa aatcattaaa aataagctga 869161 ccgcacgaaa cggtcagctt attttatttc gacattttct ttttattata agactcatca 869221 aattcttttc cttctaatcc cttatctaaa gtcagcggct ctcggcaatg catgcacata 869281 tcgactactc ctaaaacctt tgtctcttta tcacagcctg gacaaatgac gcgaaccgct 869341 ttagtcgaaa gcattccgat ccaaaagtaa actaccgtgc tgagaccgat ggataaaagc 869401 ccaagtatca taaacaaact agaaagcaaa actgactctt tgaaaaagat cccgatgtac 869461 ataatgataa acccaacgaa aaccaaactt aacgcaaatg ttctgatttt attaattttg 869521 ctggagtatt tcgccatgtc catccccctc tgttttaact atagcacaaa cccgatggga 869581 ttttcttcat gttttcggtt gaactggaat ttacatatgg agagttactg tgaaattgtt 869641 tataatagtt caatgtgttt agaaaaaagg aatttcgttt taaccataga attgaatcaa 869701 atagagaata aaaaaatttg aacaattgca ttggaggaat agtgatggaa aatcttctcc 869761 gtccaattta ccaagaaaga gcaagtcacc ccaatacatt ggctgtcatt atgattgaga 869821 gaagaaacaa aacatcttcc ttaacagata actttgatgc agctttgctg gtgattgtaa 869881 aggatgctga tgagccagtt tttataaagc attatgaatt tgatcatcaa acagcttctt 869941 tgcatgtggt aacagattct cagattcaag aatggatttt gcttggaaca aatagaagaa 870001 tcatagattg gattgtaaat ggcagagtct tgtttgaccg taatgaatac gtagttgaac 870061 tgattgacag gctgaataca tttccgtttg ccgaacgtaa actgaagatc ggactcgaat 870121 acggcaaatt aatcagaagg tatgttgaag ggaaagcttt ttttgaagcc aatcaatttt 870181 tagatgccta caatgccgtt gttcatgcgc tgcatcattt agcacgtatt gaagtaatcg 870241 acagaggatt ccatcccgaa accacggtgt ggagccaagt gcgccagatg gagccccaag 870301 tgtacaaatt atattccgag ctgattgaaa gtcatgagag cctggaaaaa agacttgaat 870361 tattattctt agcaaatgat tttctcatcc attccaaagc cgagatcggt tcggcgcatc 870421 ttttcgaagt aatgaaagaa aaagacattt ggcaattcgg tgagcttctt caacatcatg 870481 acctaaagca ctttacccaa gatcttggcg ttatgcttga ttacttgacg gaaaagggac 870541 ttatcaacgt ctgccagata gaaacgaaag gacaggctgt ctatcaccga ggatattctt 870601 ttaaaaaagg tgttgactct gattcttgac cgtgttatat tattaaacgt cgctgatgcg 870661 cttctgagaa aacaagctca cagcggcggg aaaataaatc aaaaaaacat ttgacaaaag 870721 aaagtcaaaa tgttatatta ataaagtcgc ttcaacaaga agtgaaaatg atctttgaaa 870781 actaaacaag acaaaacgta cctgttaatt cagtttttaa aaaatcgcac agcgatgtgc 870841 gtagtcagtc aaactagggc ctgcacgacg caggtcacac aggtgtcgcc gcaggatgcg 870901 gtgaacttaa cctgtgatcc atttatcgga gagtttgatc ctggctcagg acgaacgctg 870961 gcggcgtgcc taatacatgc aagtcgagcg gacagatggg agcttgctcc ctgatgttag 871021 cggcggacgg gtgagtaaca cgtgggtaac ctgcctgtaa gactgggata actccgggaa 871081 accggggcta ataccggatg gttgtttgaa ccgcatggtt caaacataaa aggtggcttc 871141 ggctaccact tacagatgga cccgcggcgc attagctagt tggtgaggta acggctcacc 871201 aaggcaacga tgcgtagccg acctgagagg gtgatcggcc acactgggac tgagacacgg 871261 cccagactcc tacgggaggc agcagtaggg aatcttccgc aatggacgaa agtctgacgg 871321 agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa gctctgttgt tagggaagaa 871381 caagtaccgt tcgaataggg cggtaccttg acggtaccta accagaaagc cacggctaac 871441 tacgtgccag cagccgcggt aatacgtagg tggcaagcgt tgtccggaat tattgggcgt 871501 aaagggctcg caggcggttt cttaagtctg atgtgaaagc ccccggctca accggggagg 871561 gtcattggaa actggggaac ttgagtgcag aagaggagag tggaattcca cgtgtagcgg 871621 tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg cgactctctg gtctgtaact 871681 gacgctgagg agcgaaagcg tggggagcga acaggattag ataccctggt agtccacgcc 871741 gtaaacgatg agtgctaagt gttagggggt ttccgcccct tagtgctgca gctaacgcat 871801 taagcactcc gcctggggag tacggtcgca agactgaaac tcaaaggaat tgacgggggc 871861 ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac gcgaagaacc ttaccaggtc 871921 ttgacatcct ctgacaatcc tagagatagg acgtcccctt cgggggcaga gtgacaggtg 871981 gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt taagtcccgc aacgagcgca 872041 acccttgatc ttagttgcca gcattcagtt gggcactcta aggtgactgc cggtgacaaa 872101 ccggaggaag gtggggatga cgtcaaatca tcatgcccct tatgacctgg gctacacacg 872161 tgctacaatg gacagaacaa agggcagcga aaccgcgagg ttaagccaat cccacaaatc 872221 tgttctcagt tcggatcgca gtctgcaact cgactgcgtg aagctggaat cgctagtaat 872281 cgcggatcag catgccgcgg tgaatacgtt cccgggcctt gtacacaccg cccgtcacac 872341 cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt ttaggagcca gccgccgaag 872401 gtgggacaga tgattggggt gaagtcgtaa caaggtagcc gtatcggaag gtgcggctgg 872461 atcacctcct ttctaaggat attatacgga atataagacc ttgggtctta taaacagaac 872521 gttccctgtc ttgtttagtt ttgaaggatc attccttcga aacgtgttct ttgaaaacta 872581 gataacagta gacatcacat tcaattagta atacaagata tcacatagtg attcttttta 872641 acggttaagt tagaaagggc gcacggtgga tgccttggca ctaggagccg atgaaggacg 872701 ggacgaacac cgatatgctt cggggagctg taagcaagct ttgatccgga gatttccgaa 872761 tggggaaacc caccactcgt aatggagtgg tatccatatc tgaattcata ggatatgaga 872821 aggcagaccc ggggaactga aacatctaag tacccggagg aagagaaagc aaatgcgatt 872881 ccctgagtag cggcgagcga aacgggatta gcccaaacca agaggcttgc ctcttggggt 872941 tgtaggacac tctgtacgga gttacaaaag aacgaggtag atgaagaggt ctggaaaggc 873001 ccgccatagg aggtaacagc cctgtagtca aaacttcgtt ctctcctgag tggatcctga 873061 gtacggcgga acacgtgaaa ttccgtcgga atccgggagg accatctccc aaggctaaat 873121 actccctagt gaccgatagt gaaccagtac cgtgagggaa aggtgaaaag caccccggaa 873181 ggggagtgaa agagatcctg aaaccgtgtg cctacaagta gtcagagccc gttaacgggt 873241 gatggcgtgc cttttgtaga atgaaccggc gagttacgat cccgtgcaag gttaagcaga 873301 agatgcggag ccgcagcgaa agcgagtctg aatagggcgc atgagtacgt ggtcgtagac 873361 ccgaaaccag gtgatctacc catgtccagg gtgaagttca ggtaacactg aatggaggcc 873421 cgaacccacg cacgttgaaa agtgcgggga tgaggtgtgg gtaggggtga aatgccaatc 873481 gaacctggag atagctggtt ctctccgaaa tagctttagg gctagcctca aggtaagagt 873541 cttggaggta gagcactgat tggactaggg gcccctaccg ggttaccgaa ttcagtcaaa 873601 ctccgaatgc caatgactta tccttgggag tcagactgcg agtgataaga tccgtagtcg 873661 aaagggaaac agcccagacc gccagctaag gtcccaaagt atacgttaag tggaaaagga 873721 tgtggagttg cttagacaac caggatgttg gcttagaagc agccaccatt taaagagtgc 873781 gtaatagctc actggtcgag tgactctgcg ccgaaaatgt accggggcta aacgtatcac 873841 cgaagctgcg gactgttctt cgaacagtgg taggagagcg ttctaagggc tgtgaagcca 873901 gaccggaagg actggtggag cgcttagaag tgagaatgcc ggtatgagta gcgaaagagg 873961 ggtgagaatc ccctccaccg aatgcctaag gtttcctgag gaaggctcgt ccgctcaggg 874021 ttagtcggga cctaagccga ggccgaaagg cgtaggcgat ggacaacagg ttgatattcc 874081 tgtaccacct cctcaccatt tgagcaatgg ggggacgcag gaggataggg taagcgcggt 874141 attggatatc cgcgtccaag cagttaggct gggaaatagg caaatccgtt tcccataagg 874201 ctgagctgtg atggcgagcg aaatatagta gcgaagttcc tgattccaca ctgccaagaa 874261 aagcctctag cgaggtgaga ggtgcccgta ccgcaaaccg acacaggtag gcgaggagag 874321 aatcctaagg tgatcgagag aactctcgtt aaggaactcg gcaaaatgac cccgtaactt 874381 cgggagaagg ggtgctctgt tagggtgcaa gcccgagaga gccgcagtga ataggcccag 874441 gcgactgttt agcaaaaaca caggtctctg cgaagccgta aggcgaagta taggggctga 874501 cgcctgcccg gtgctggaag gttaagagga gcgcttagcg taagcgaagg tgcgaattga 874561 agccccagta aacggcggcc gtaactataa cggtcctaag gtagcgaaat tccttgtcgg 874621 gtaagttccg acccgcacga aaggcgcaac gatctgggca ctgtctcaac gagagactcg 874681 gtgaaattat agtacctgtg aagatgcagg ttacccgcga caggacggaa agaccccgtg 874741 gagctttact gcagcctgat attgaatgtt ggtacagctt gtacaggata ggtaggagcc 874801 ttggaaaccg gagcgccagc ttcggtggag gcatcggtgg gatactaccc tggctgtatt 874861 gaccttctaa cccgccgccc ttatcgggcg gggagacagt gtcaggtggg cagtttgact 874921 ggggcggtcg cctcctaaaa ggtaacggag gcgcccaaag gttccctcag aatggttgga 874981 aatcattcgc agagtgtaaa ggcacaaggg agcttgactg cgagacctac aagtcgagca 875041 gggacgaaag tcgggcttag tgatccggtg gttccgcatg gaagggccat cgctcaacgg 875101 ataaaagcta ccccggggat aacaggctta tctcccccaa gagtccacat cgacggggag 875161 gtttggcacc tcgatgtcgg ctcatcgcat cctggggctg tagtcggtcc caagggttgg 875221 gctgttcgcc cattaaagcg gtacgcgagc tgggttcaga acgtcgtgag acagttcggt 875281 ccctatccgt cgcgggcgca ggaaatttga gaggagctgt ccttagtacg agaggaccgg 875341 gatggacgca ccgctggtgt accagttgtt ctgccaaggg catcgctggg tagctatgtg 875401 cggacgggat aagtgctgaa agcatctaag catgaagccc ccctcaagat gagatttccc 875461 attccgcaag gaagtaagat ccctgaaaga tgatcaggtt gataggtctg aggtggaagt 875521 gtggcgacac atggagctga cagatactaa tcgatcgagg gcttaaccat atttttgaat 875581 gatgtcacac ctgttatcta gttttgagag aataagtttt tcaaaaaaac acttgatttt 875641 ctcaagaata catagtataa tgttaaatgt cactgaaatt gtctggtgat gatggcgaag 875701 aggtcacacc cgttcccatg ccgaacacgg aagttaagct cttcagcgcc gatggtagtc 875761 gggggtttcc ccctgtgaga gtaggacatc gccaggcaga cttcattccg cagtagctca 875821 gtggtagagc tatcggctgt taaccgatcg gtcgtaggtt cgaatcctac ctgcggagcc 875881 attattggag agctgtccga gtggtcgaag gagcacgatt ggaaatcgtg taggcggtca 875941 actccgtctc aagggttcga atcccttgct ctccgccact gatacttata cataattaca 876001 attgaaagtc tgggcccgtt ggtcaagcgg ttaagacacc gccctttcac ggcggtaaca 876061 cgggttcgaa tcccgtacgg gtcattatat gatggaggat tagctcagct gggagagcat 876121 ctgccttaca agcagagggt cggcggttcg agcccgtcat cctccaccat tatatcatcg 876181 cggggtggag cagttcggta gctcgtcggg ctcataaccc gaaggtcgca ggttcaaatc 876241 ctgcccccgc aaccaaattt taaaatggtc cggtagttca gttggttaga atgcctgcct 876301 gtcacgcagg aggtcgcggg ttcgagtccc gtccggaccg ccatttgaat acttaggctc 876361 ggtagctcag ttggtagagc aacggactga aaatccgtgt gtcggcggtt cgattccgtc 876421 ccgagccacc acctatgccg gtgtagctca attggtagag caactgactt gtaatcagta 876481 ggttgggggt tcaagtcctc ttgccggcac tgttttttca aaatttaatg tggaggggta 876541 gcgaagtggc taaacgcggc ggactgtaaa tccgctccct cagggttcgg cagttcgaat 876601 ctgcccccct ccaccattta taggggcata gtttaacggt agaacagagg tctccaaaac 876661 ctccggtgtg ggttcgattc ctactgcccc tgccaaattt atgacatctt gagattatgg 876721 cggttgtggc gaagtggtta acgcaccaga ttgtggctct ggcactcgtg ggttcgattc 876781 ccatcaatcg ccccatatta tcattgggct atagccaagc ggtaaggcaa cggactttga 876841 ctccgtcatg cgttggttcg aatccagcta gcccagtctc actttttata tcaactgcat 876901 ataatgtatt aagtccatta aaaatgcgga agtagttcag tggtagaaca ccaccttgcc 876961 aaggtggggg tcgcgggttc gaatcccgtc ttccgctcca attacggcgg catagccaag 877021 tggtaaggca gaggtctgca aaacctttat ccccggttcg aatccgggtg tcgccttctt 877081 attgccgggg tggtggaatt ggcagacaca caggacttaa aatcctgcgg taggtgacta 877141 ccgtgccggt tcaagtccgg ccctcggcac caattttact tacatggtaa gttgaattgg 877201 tgtttgtgtt ttatcattat aactaatcat attaatgatc tacataagta gatcattttt 877261 ttaatgcttt gatttatcat aacaagttaa gttccgaggc ctattataaa gcggctgtat 877321 agctagtctt tcaacacttt tattttatat ttccataaaa acttttttga aatacgttga 877381 cactttatga gatccatgat atatttatat tcgtcggtta gatacgacgt aaaacttgcc 877441 ggtgtggcgg aattggcaga cgcgcacgac tcaaaatcgt gttccttctg gagtgtcggt 877501 tcgaccccga ccaccggtat actgaaaaac ccgtttctta acagaaacgg gtttttattt 877561 tttattaaag aaaaggagcc tcggctcctt tttatactta ctcagcgtat tggtctagga 877621 tctcttctag cacctcttct agctcttctg tatcttcaag ctctgattgg ctgaaacgga 877681 cgcgtacaag ctgttctccg tcattataca tctcttccaa ccaccctcgg agtcctcttg 877741 ctctgcggtc gacttcgaaa atgatttcca aaccgtcttc gtctaaaagg aaaatgagct 877801 ctaattcatc aagcatctga cgataatatc cggaagtcgg aacgaattcg aattcttgaa 877861 cgaacggaag acgacgctgg aagtagggcg cttgttcgca gtctgcttcg ttaagacgga 877921 agcccaggtt ttcgattgct tcaagcacat tttcaatcca agggtgcgct tcaacgaaaa 877981 tgcggtcatg atcggattta tcgataccgc cttgaatgtc aaggtctgtc accacggcaa 878041 cctctacttt ccctacagtg atcggcgtat ctagaggcag agtgaatgtg aacggaaatt 878101 gatgctcttc accaggctgt atggtaaatg aaccagtgac ccggaaagaa tgaattgtag 878161 cgtatttccg gtgctcttca tcgtctttta caatgacata ccgtgtgcta agctgtaaat 878221 cgatataacg gatgtcctga gcgatttttc cgcctttgac atgtaccgtt ccctgtactt 878281 cttctcctgg aaaatatgcg tctttttcta aaattgtatc tacttttgca gctccaattc 878341 cggcacttgc cgcaagcttc ttaaaaaatg acatgttaga tcttcccctt tttctttttt 878401 ctcaacagat atacgtaaga aggaggaaaa aagattcgtt tgattcatac ttttttccta 878461 ttattcgtct cggcctaggg acagactaag aataatattg aaaataaagg agtcgatgga 878521 agtgaataaa gaaagtttgg ttgcagatga attacacaga atgtttttgg ctggtgagct 878581 gcaaatcaca gtagaggagg atataaacaa tatttccgaa aggctgagaa acggcgatct 878641 cagtttagac cgattaagcg gtgaagacgt gtttataaaa gaaacggtaa atgaggcttt 878701 aagaagagtg gagcaataaa aaagagacgg catctcatct ttgagatccc gtctcttttt 878761 gtggtctttg ctgtaagata aaagcgaatc gatttggaat tgctcacccg agccacccct 878821 tttctaacag aagatctgac agttcatcat ggagataaac agctgtatct aattgatcat 878881 gcaatgctct tctgatgtgg ggattttcgg ttgctgttgt tgcgacagtg tatttgttaa 878941 tgctggtttt tattgttgtt aacaaatcaa gaatatcttt gggacaaaga ctttgttcaa 879001 tgggaaacca cctcctttgt ttttttagca gctcctgata agaaagtatt tgactttgtt 879061 tcttgcttct atacaaaatg ctataataag caacaaattt tgttgggggg tgtgatgatg 879121 aagcagatta ttgcgatggg gggcgggggt ttttcgatgg agccggataa tttgtccctc 879181 gatcaatata tcctcaatca atcaaaacga gagcagcctc gtatttgttt tttgccgacg 879241 gcgagcggag attcccaaaa ctatattcag cggttttatc atgcatttca aacattggat 879301 tgcgtgccgt ctcatttatc tttgtttaag ccaccatcat cagatttagt ttcttttgtt 879361 atggaaatgg acgtgattta tgttggcggg ggaaatacgc ggaatttact tgtgttatgg 879421 aaagagtggg ggctggacca tattctcagg gaagcatgga agaacggtgt ggttgtagct 879481 ggaataagtg ccggtgcgat ctgctggttt gaagaagggg tgacagattc agccggaccg 879541 ctgacaagtt tgaaaagttt aggttttttg caagggagct tttgtcccca ttatgacggg 879601 gaaaaggatc ggagaccggc ataccaccag ctgatatcta acaagttctt atgcagtggc 879661 tatgcagcgg atgatggggc tgctctccat ttcataaatg atcagctgtt tcagactgtg 879721 agttcaaggt cgggtgcaaa ggcatatcgg gtgatgatgg ctgaacatga aatagctgaa 879781 atcccgttgc cggtcaaata tttagggtga aattggctga atattatcta tattcctctt 879841 tttttcagat tgattttatg ataagatgag tgcgaaatca atagttactg ggggtgcccg 879901 ctttcgggct gagagagaag gcaagcttct taaccctttg gacctgatct ggttcgtacc 879961 agcgtgggga agtagaggaa ttgtttttgt tattgtcttg ctgggcaata atatgtttct 880021 ttctgactgt aaccgggttc atttatatga atccggtttt ttgtgctggt tatgggcttg 880081 attttgtcct ttcaaacgta gaaaggggaa ggaaaagtaa tgcaaaacaa ttcagtgcag 880141 caagccaaca tttccattat gtcaagtttt tcaggcagca agaaggtata cgtggagggt 880201 tcttcttcgg acatccaagt gccgatgagg gagattgcat tgagtccgac gacgggatcg 880261 ttcggcgaag aggaaaacgc gcctgtgcgt gtctatgata caagcggacc gtatacggac 880321 cctgaagtaa ccattaatat tcaagaagga ttaaagccgc tccgccaaaa atggatcaca 880381 gagcgcggtg acgtggaaga gtatgaaggt cgggctataa aaccagaaga taacggttat 880441 aaaaaagcaa aaccaaacgt aagctatcca ggattaaagc ggaaaccgct gagggcgaag 880501 gcaggtcaaa atgtcacaca aatgcactat gcaaaaaagg ggatcattac acctgagatg 880561 gaatttatcg ccattcgtga gcatgtgtct cctgaattcg tcagagacga ggtagccagc 880621 ggccgggcga ttattccttc aaacattaat caccctgaaa gtgagccaat gattatcggc 880681 cggaattttc atgtgaagat taatgcaaat atcgggaatt cagcggttac gtcatccatt 880741 gaagaagaag tggaaaaaat gacgtgggcc atccgctggg gagcggatac gatgatggat 880801 ctctctaccg gaaaagatat tcatacgacg cgtgaatgga ttatccgcaa ttgccccgtg 880861 cctgtgggaa ctgttccgat ttatcaggcg cttgaaaaag taaacggcgt agctgaggat 880921 ttaacgtggg agatttatcg tgatacgcta atcgagcagg cagagcaggg agtggattat 880981 tttacgattc acgcgggtgt tttgcttagg tatgtaccgc tgactgccaa acggacaact 881041 ggtatcgtgt cacgcggggg agcgattatg gcgcagtggt gtctggctca tcatcaagaa 881101 agctttttat acacacattt tgaagaaata tgtgagatta tgaaaatgta tgatattgct 881161 ttctctcttg gggatggttt gcgtcccgga tcaattgctg atgccaatga cgaagcgcag 881221 tttgctgaat tagagacgct tggagagctg acgcaaattg cctggaagca tgatgttcag 881281 gtgatgattg agggtcctgg acatgttccg atgcataaaa tcaaagagaa cgtcgataaa 881341 caaatggaca tttgtaaaga agcgcctttt tacacattgg ggccgttgac aacggatatt 881401 gctccgggat atgaccatat tacttcagcg atcggagcgg cgatgatcgg ttggtacggg 881461 acagcaatgc tttgttatgt aacgccgaag gagcatttgg ggctgccaaa ccgtgatgat 881521 gttcgtgaag gagtcattac atataagatc gctgcgcacg ctgcggacct tgcaaaaggg 881581 catcccggag cgcaaatccg ggatgatgcg ttatcgaaag cccgttttga attccgctgg 881641 cgggatcagt ttaatttatc tcttgatccg gagagagccc ttgaatacca tgatgaaacc 881701 ctgcctgctg aaggagcaaa aaccgctcac ttttgttcca tgtgcggtcc gaaattttgc 881761 agcatgagaa tttcacagga tattcgggat tatgcgaaga aaaacgatct cagtgaagca 881821 gaagccataa ataaaggatt aaaagaaaaa gcaaaagagt ttgtcgatac gggaagcaat 881881 ttatatcaat aaaaaaaatg aagatggaga atgctccatc ttcatttttt tagaaaaaca 881941 gagagcgtcg aagcggagga atactctgtt caaagcggaa aacattttct ggatcatatg 882001 tcgttttgac acggcggagt cgttcaacgt tttcgccgta atatgttctt ggccagtttc 882061 tgatttcgat atctggccaa tttacgtagt ctcccatcgt ttctttcgaa agggacgttc 882121 tcagcccctc aatccagcgg acattttgtc ttttttctcc aggggatgtc cagtttgtta 882181 agtattcctg ggcgatgatt gcgtcacgat aataaaatgc cgtttggtcg ggagcgaccc 882241 gtccggctgc cccgccgagt gcttgctgcc agacactggc gttttgattc ggagcgtgct 882301 ctaaaaagtg ttttattgtt gagatcgcac gttctgataa tggcttttca atgaaagagc 882361 cggagcgttt cattttttga ggctgattgc ctcccgggct gttaaaaaag gttaccgctt 882421 caatgaatgg cgttgttttt accattccgc ttgtcggact tcctgctttc aataaaggct 882481 ttaacagttt ttttaactct gtttttggcc cgacaaattg gccgagggct tctatgcggt 882541 ttacttcttt aggccaaaac tctattgatg atgtaagccg gtcatctgta tacggggccc 882601 agttctgcca cgtgttatat acttcctcaa aatcatccca tccccatgta atagaaaaaa 882661 tcgacacttg agagatgggc actgctttaa atgtcatgga ggtgactatg ccgaaattgc 882721 ctcctccgcc tccctgagac gcccaaaata agtctggatg atttgaacag ctgactgtaa 882781 tcagatcagc gccctctttt tcgtctgcta cgatcatctc aagctgcacg aggctgtcgc 882841 aagtaagacc ggcagccctt gttaaaagtc caattccccc tccgagagtt aaacctgtga 882901 gccctacatt agcaatggtg cctgcgggaa gcgtcaggcc gtattgccag agtgtccgat 882961 agacttctcc caattcagcc cccgcttcaa tataggccag ctttttatcc tgattcacag 883021 ttattttttt catctcgctt aaatcaataa caagaccgtt atttaaaagg gaaaagttct 883081 catagctgtg tctgccgcct ctaatacgga aaggcacacg gttttcacgc gcccatttca 883141 gcgcattgag tgcatcctgt ttgttttggc aaaacacaat gatgtcagga tacctttcta 883201 agcttaggtt aatattggtt cttgcttcgt tatagtccgg atcatcccgt gtcacgatac 883261 gtccggtcaa ttttgtcttt tccacactcc cacatctctt tctctcgtat tctagtttct 883321 ctagcttatg cgtcagggga aaagagtgta taaggaaaaa gcggggatgc aatctgatac 883381 agtgtcaaca ccctcaaaaa atagttgaca ggtcggtatt gtatgaatta acatggtcag 883441 tacaaatttt tcaaatttat cgcgctgatc ggaacaccga aggctcttat cgtttagata 883501 agggcctttt ttgtatgaaa aaggggggat tattgatggg agtcaaaaaa gaaaagggga 883561 gaaaacgatt caggaagcga aaaacctacg ggaatcagat tttgccgctt gagctgctga 883621 ttgaaaaaaa caaacgagag attataaaca gcgcggaact catggaagaa atttatatga 883681 agattgatga gaagcatacg caatgtgtaa ctaaatataa aaaaacccgc tgactacaac 883741 gggtttttgc atttctccat taagaatctt ttttaatcgg caatccaagg ccttctgcca 883801 cgcgttttcc gtattcagga tccgctttgt agaagtgctc gatttggcgc agcttgattt 883861 cttctttttc taccggcttc atggcattaa cgatattttc aacaaggcgg gtacgttcat 883921 cttcactcat taaacgatac agatcgccgg cttgagtgta gtgatcgtag tgatcgtagc 883981 ttacgctgtc agcgatacct tgtaccggat atgctgcttg cttatcctca ggtgactctt 884041 ttggaccgcc gaagctgtta ggctcgtaat acacagatcc gccgccgtta tcatcaaaac 884101 gcatttgccc atcacgctga taattgttta ctttgttgcg tgcgcggttg attggcagcg 884161 cttgatggtt tgcaccgaca cggtagcggt gtgcatcatg ataagcaaaa agtcgacctt 884221 gaagcatttt atccggtgaa acatcaatac caggcacgag ggttccaggt gaaaatgtcg 884281 cttgttctac ctctgcaaag tagttttccg gatttctgtc tagaaccatg cgtccgacct 884341 cgattaacgg gtagtctttt tgagaccaaa cttttgtgac atcaaacgga tcgaaacggt 884401 acgtatttgc atcttctaaa ggcatgattt gcacatatag tttccatgca ggataatcac 884461 cgttttcgat tgcgttgaaa aggtcttctg tatggtaatc agggttttca ccggcaattt 884521 ttgctgccgt attgacatca aggtttttca cgccttgttc tgttttaaag tgatatttaa 884581 tccatacgcc ttcgccttcg gcatttgtcc atttgaatgt atggcttccg aagccgtgca 884641 tgtggcgaag tgtcgcagga attccgcggt cagacatcag gattgtcact tggtgcagtg 884701 actctggtga aagtgaccag aaatcccata cagccgtagg gtttttcagg tgtgtttttg 884761 gatctctttt ttgtgtatgg atgaaatcag ggaacttaat cgcatcgcgg ataaagaata 884821 caggcgtatt gttgccgacg atgtcgtagt ttccttcttc agtataaaat ttaacagcaa 884881 atccgcgcgg gtcgcgaact gtgtcagcag agccaagttc accggcaact gttgagaaac 884941 ggatgaacaa cggtgtgcgt ttgccgactt cagaaaggaa agcggctttc gtgtattttg 885001 ttacgtcgtt tgtcacttca aaatatccgt gtgcgcctgc tcctttggcg tgaacaacac 885061 gttcaggaac acgttctcgg ttgaaatggg ccaatttttc gagtaaatgt acatcttgaa 885121 ttaaagttgg tccgcgagaa ccggcagtca ttgagttttg attatctcca accggagcgc 885181 cccagctagt tgtcagttta tttgaactca tgttatcacc tcttggaatt tataagaaca 885241 taatatcatc tctaagtaaa aagtcaatat tattttataa ttattataaa atagttatct 885301 ctattaatcg atatatagta tcgaaattgt tgaaaaacct tgttgtaaca gctttttatg 885361 acacttaata atttttggag aaataatttt tccttctcta tttgcgaaac aagcagagta 885421 agtgataaac aaggatatca aaaatcgtat ttaaaaaaga gttgacatat cggaataatt 885481 tgaattaaca tgttattcaa acaaaaaaac aattgggcag ctgatcggac cgccgaaggc 885541 tctcatctct acaagaacag agatgggggc ctttttgttt tttttgaagg cggggttggc 885601 agaaagagag ggataaaagt ggctgtgacc atcagcatca aagaaaaggc atttgttcaa 885661 gaaggccgca aaaacacggt cttagaaaac atagaattat caatcgcacc aggcgaattt 885721 ctaacgctta tcggaccgag cgggtgcgga aaaagcaccc tgttaaagat tattgcaggg 885781 cttgattctg aatatgacgg gagtgtggaa attaacggcc gcagcgtaac agctccgggt 885841 attcagcaag gatttatttt tcaggaacac cgcctctttc cttggctgac tgttgagcag 885901 aatattgcag ccgacttgaa tttgaaggac ccaaaagtca aacaaaaggt ggatgaactg 885961 atcgagattg tcagattgaa aggatcggaa aaagcatatc cgcgcgagct gtcaggcggc 886021 atgtcacaaa gagtagccat cgcccgggcc ctgctgcggg agcctgaggt gctgctttta 886081 gatgaaccgt ttggtgcact cgacgctttt acaagaaaac acctgcagga cgtgctgctg 886141 gatatatgga ggaagaaaaa aacaacgatg attctcgtga ctcatgatat agatgaatct 886201 gtttatttag gaaatgagct tgcgatcctt aaggccaaac cggggaaaat ccataagctg 886261 atgcccattc acctggcgta tccgcgaaac cggacgactc cggatttcca agcgatcaga 886321 cagagagtgc tgtcggaatt cgagaaaaca gaagatttgg agtacgcaga aggatcaggg 886381 atatagaaag ggcggaagcg gaaatgaaaa aaggactcat tgtattggtt gccgttattt 886441 ttctgctcgc aggctgtgga gcaaatggag ccagcggtga ccacaaacaa ttgaaggaaa 886501 ttcgtattgg tattcagcaa agcttaagcc cccttttgat tgcaaaagaa aaaggctggt 886561 tcgaagatgc atttgaaaaa gaaggcatca aagtgaaatg ggtggagttt caaagcggtc 886621 cgccccaatt tgaaggcctt gcggcagaca aacttgattt ttctcaagtc ggtaattcgc 886681 ctgtgatcgc tggacaggcg gcaggcattg actttaaaga aatcggtttg tctcaggacg 886741 gcttgaaagc aaacggcatc cttgtcaatc aaaacagcgg cattcaagac gttaagggct 886801 taaaggggaa gaaaattgca gtcgccaaag gcagcagcgg gtttgatttt ttgtataaag 886861 cgcttgatca agtggggttg tcagctaacg atgtgacaat tattcagctt cagcctgatg 886921 aagcagcttc cgcatttgaa aacggatctg ttgatgcctg gtccatttgg gagccgtact 886981 tgtccttaga aacaatgaaa cacggagcaa aaatccttgt gaacggagaa agcacagatt 887041 tatattcacc gggttttact ttagtaagaa caaagttttc agaagagcat ccagacgaag 887101 tggtccgttt tctgaaggtg tttaataaag ccgttgtatg gcaaaaggaa catctggatg 887161 aagcagcgga cttatattct gacattaaag atctcgataa aaaggtcgtc gaaaatgtgc 887221 tgaaaaatac tgagccactt aatgagatca tcagtgacga cattgtgaaa gcacagcagg 887281 aaacagcaga ttttcaattt cgaacaaagg cgatagataa gaagattgat gtgaaggatg 887341 ttgtcgataa cacttttatc aaaaaagcat tagaggagca ttcctcagga ggtgatcaat 887401 gatgaaagca gaggctgcgg gctcgctgcc caaaacgaat gcggaagcgg tgcgaaaaaa 887461 gcccggaagg aagagatacg gctggatgaa ggggctttta ctgcccgctg tcatcattgc 887521 catctggcag gtcatcggcg ggctgggggt tgtgtccgct acagtgctgc ctacacctgt 887581 tacgattgtt ctgaccttta aggagcttat tttgtccggc gaactgttcg gccatctgca 887641 aatcagcatt tatcgggcgg cacttggttt tttgcttggc gcggggcttg gattgatgat 887701 cgggattttg gccggatttt ccaaacggac ggagctgtat cttgatccgt cgttgcaaat 887761 gcttagaacc gtacctcatc tggccgtcac gccgctgttt attttatggt tcggatttga 887821 cgaagtatct aaaattttgc tgattgcgct cggtgccttc tttcctgtct atatcaatac 887881 gtttaacggc atccgcgggg ttgacgcgaa gctgtttgaa gtcgcccggg tgcttgaatt 887941 taaatggcat cagcagatat ccaaagtgat attgccggca gccctgccca atatattgct 888001 aggcattcgc ttatcgctcg gcattgcatg gctcgggctc gttgtggcag agctgatggg 888061 ctcaagctcg ggagtcggct atatgatcat ggatgcgaga cagttttcac aaacgaataa 888121 agtctttgca gggattatca tttttgcagt ggttggaaag ctgacggatt ccttcgtcag 888181 gctgcttgaa cgaaagctgt taaagtggag aaacagctac gaaggataaa agatataaag 888241 gggagatgaa tatggaaatt ctttggttta taccgactca tggagacgcg agatatttag 888301 gatctgaaag tgatggacgg actgcggatc atctttactt taaacaagtc gcgcaggcgg 888361 cagacaggct gggatataca ggagttcttc tgccaacggg aagatcgtgc gaggacccgt 888421 ggcttacagc gtcggcactg gcaggagaaa caaaggactt aaagttttta gtcgcggtaa 888481 gacctggttt aatgcagcct tctctggcag ccagaatgac atccacccta gaccgcattt 888541 cagacggccg gctgctgatc aacgttgtgg cagggggcga tccgtatgag ctggcaggcg 888601 atggcctgtt tatcagccat gatgagcgct acgaggcaac agacgaattt ttaaccgttt 888661 ggcggagact tttgcaggga gaaacggttt cctatgaagg aaagcatata aaagtggaaa 888721 acagcaatct gcttttcccg ccgcagcaag agccgcatcc gcccatctat ttcggtggtt 888781 cgtcacaggc tggaattgaa gctgccgcaa agcatacaga cgtgtacttg acatggggtg 888841 agccgcctga acaagtaaaa gaaaagatag aaagagtcaa aaagcaagcg gcaaaagaag 888901 ggagatccgt tcgatttggc attaggctgc atgtcattgc ccgtgaaact gaacaagagg 888961 catgggaagc ggcagagcgc ttgatcagcc acttggatga tgacaccatt gccaaagcgc 889021 aggcagcttt gagccgttac gactcttcag gccagcagcg gatggccgtc cttcatcaag 889081 gcgatcggac gaagcttgaa atcagcccga atctgtgggc ggggatcggc ctggtcagag 889141 gaggggcagg aacagctctt gtcggtgatc cgcagacgat tgccgaccgg atagcggagt 889201 accaggcact cggcatagaa tcgtttatat tctccggcta tccgcattta gaagaagcgt 889261 attattttgc agagcttgta tttccgcttt tgccgtttga aaatgatcgg acgagaaagc 889321 ttcagaacaa aaggggagaa gcggtaggaa acacttattt tgtcaaagag aaaaatgcat 889381 gagtttaact aaaatacagc cccccgaaca tggtatgata ttcaaaaaaa gggggctttt 889441 tttctgaaaa cattgagaag cgcggcagtc atttgcctca tagctatgct gtcagcatgc 889501 ggacattcaa aacagatgga aatcaaagcg gcggacatat cagatcttga aaaaaacaga 889561 atggatgtcg cagcttcaca ggcattcact gccgaagccg tcaatatcgg tgaaggtatt 889621 tcttcagctg acatgtacat cgaacattat caaaagggaa agcttgttga gaggtttgga 889681 ccggttcgtg cagattattc agaggaaaaa actgatacca tacaatttgt ttattttgag 889741 aatgaagagg gggaaggaaa gaataaacat accaccattc attttggcat tgtggataaa 889801 cagggaacta tagcggctga ttcatcggtg aaacgcgacg atagcacaac acaggaaatg 889861 actcagaata tttcatcgcc ggaaccgatt actttcgaga agcctgcttt gatcggcagc 889921 agtattagag ggactgacga gacaatgcac acctctgaac ataaaaaaga gctcattaag 889981 catcaagatg cgttactgta ttatgtggaa ttgcatcatt agaatgggcg gcttcaggcc 890041 gtctgtttta caaagcggta tgcttgcttt tttgaatggt gaatgataca ttttaaatcg 890101 taacaatttc gatttaaagg gaggctatgt gacttggcta aaaaatcaaa agtggcaaaa 890161 gagttaaaac gccaacagct tgttgagcaa tacgctggta ttagacgcga gttgaaggaa 890221 aaaggagatt acgaggcact cagcaagctg ccaagagatt cagcaccggg aaggcttcac 890281 aaccgctgca tggtaacggg gcgcccgaga gcatatatga ggaagtttaa aatgtccaga 890341 atcgctttca gggagctggc ccataaaggc cagattcccg gtgtgaaaaa agcaagctgg 890401 taagaaaaaa ctccggccga ttacagcgcg ccggagtttt tttcgttttt cttgaaagag 890461 atgacgtagg aaaggtgctg gatgatcatg atgataaaca caataataat agggaaaaac 890521 ggaatgcgcg attgaaatag cggataaaaa atgagaagaa ccgctgcggc aggcagcgag 890581 aagtagacag cgatatatga cgcgcgacat gcttttgccg tcatcatctg ctctctttca 890641 tcctgctctt caaactcatc aggcagaagt agctgctttc tggcagggcg gctttttttc 890701 tgtaagtaca aataaaccgc agacgccgca acaaacagaa taaagggagt gaggtttaaa 890761 tcaaatacca tcccgccgct ctttgtgccg aaaaaagatg ctatgccttc tgaggcttca 890821 aagtatgaaa tcagcgccca gcatgcaagg ccaaataaaa caaggtgaaa agctgctttt 890881 gttttcatgc tcatcttagt tttcctcctc taaccaaaag acatcctcca ttttcatgga 890941 gaaggctttg cagattttca gtgctaacag cagtgaggga acataatcgc ctttttcaat 891001 cgctgccaca gtctgtcttg tgacgccgac cgtttctccg agtttttcct gagaatagcc 891061 gaagcgtgcc ctcagctctt ttactttatt tttcatcatg acgtctgtcc ccttcacaat 891121 ctcgattgat tatattgtat agtatactta acattatgta aatggaactt aacaacttta 891181 caaaaagata actttttttc gacaaaattt ttatattccc ttgacgaaaa ataaataaac 891241 atgtaatata aaaaaagtca gagcggtact gttgctgaca atcacaaatg cgggtgtagt 891301 ttagtggtaa aacctcagcc ttccaagctg atgtcgtgag ttcgattctc atcacccgct 891361 ccatacatac gttattaacg cagtgtttcg tttctcagat aaacgaagta ttgcgttttt 891421 ttatgtgaaa aagaacacgg tattcgtgtt cttttacgta agccaatgta ctgtatgggt 891481 gccgccgtga atttgttcaa acattttcgt taatgatgat aagaggttaa cagcgctgct 891541 tttctcaatc gatggcggga aaaaaatgat ttgcagcata ttcttagtct cgtttgaaac 891601 gggatagtgg ttgacgctgt ttttgaaatc gccaaaaatg ccgttttcat cagagaaaag 891661 cagtatgttt tctttttctc ccaatgagat ccggaccggc tcatgaagct ttccggcatc 891721 ataaatcata ataggcagag aatattttaa tgcgaaaaaa tcgattgtgt catgggccga 891781 gtctttactt tccatgaatt gttccttgga tatcgggacc agcatgtcct ccattggggt 891841 tgtttctccc tcaaatgaag ggttaagctg tttaaagagt ttctgccatt ccttgacgaa 891901 ggattcatcg gatataccgc cgtccgcata gtcgaaaaac aaggattctt gaaacaggcg 891961 gagtctgcct ttcagcattt gcggtgagga gccgacttcg atattctcat aaatgacagc 892021 agctgcatgt aagccggccg cacgttcagt aataacagaa tcaagtttga tattcactag 892081 cattcactcc agttacgtga tatcaaccta ttataaacgc tgtgtcgttt tatcacaaag 892141 aaaggaggct gtgcaaaaca tgaacgttta tcagctcaaa gaagaattaa ttgaatacgc 892201 gaaaagcatt ggcgtagaca agattggttt tacgaccgct gatacttttg acagtttaaa 892261 agaccgtttg attcttcaag aatcactcgg ctatctctcc ggctttgaag agccagatat 892321 cgaaaaaagg gtgacgccga agcttctttt gccgaaagcg aaatcaatag tggcaattgc 892381 tctcgcatat ccttccagaa tgaaggatgc gccgagaagc acgagaactg agcgcagggg 892441 cattttttgc agagcttcct ggggaaaaga ctatcatgat gtgctgaggg aaaagcttga 892501 tctgctggag gattttctaa aaagcaagca tgaggatatc agaacgaagt caatggttga 892561 tacaggtgaa ttgtctgatc gcgccgttgc ggaacgtgcc ggaatcggat tcagtgcgaa 892621 aaactgtatg atcacaacac ccgagtatgg ctcttatgtg tatttggcgg aaatgatcac 892681 aaatatccct tttgagcctg atgtgccgat tgaagatatg tgcgggtcct gcacgaaatg 892741 cttggacgcc tgcccaacgg gagcactggt taatcccggg cagcttaatg cgcagcgctg 892801 catctctttt ctgacccaga caaaaggatt tttgcctgat gaattccgga caaaaatcgg 892861 aaaccgcctg tacgggtgcg atacgtgcca aacggtatgc cctctcaata aagggaagga 892921 ttttcatctt catccggaaa tggagcctga tcctgagatt gccaaaccgt tattgaagcc 892981 gcttttggcc atcagcaatc gggaatttaa ggagaaattc gggcatgtct caggttcttg 893041 gcgcggaaaa aaaccgattc agcgaaacgc cattctcgcg cttgcccatt ttaaggatgc 893101 ttccgcactg cctgaattga cggaactgat gcacaaggat ccgcgtcctg tcatcagggg 893161 gacagccgca tgggcaatcg gaaaaatcgg agaccccgcc tacgcggaag agcttgaaaa 893221 agcgctggaa aaagagaagg atgaagaggc aaagctggaa attgaaaaag gaattgagtt 893281 gctaaaagct tcaggcatga ctaaacaagg cctgtcctga catacgtata gagcagaagg 893341 aaaaaacact tgagatcatc caagtgtttt ttctctataa aaaagtatgg cgggtggggt 893401 gagcttgaag tacattttag aacaattagc ggaggagcgg ctgggctttc tggttaacgg 893461 gcatgctatg agacaggagt ctcaagtcgg agaccttaaa gtcatggagc gtaagaaaaa 893521 gcttctggaa aaacgtaaag ttgacatcat aaaagcgaaa gcaaaggccg tgattaatca 893581 tgtgcgggtt gaggatgacg gaacgacctg cctttcgtat accatccatt acgaatacgt 893641 gtgtaaggaa caagatgaca gcttgtatat agaagagcac atagaggagc gaatggcttt 893701 cctgtatgat cacattttga ttagtgatca ggaaattgcg aaaaagccgg ctggatttca 893761 tgaagggacc agtattattg actattctga agctgaagag gaaagagaag cgtttggcag 893821 ggcttttcaa tacgatcgtc tcggcgctgt ccaatatgcc gagaaatttt ggaacaagcg 893881 caatcctgct tataaaaatt tcagcgataa ctgtacaaat tttatttctc agtgtcttca 893941 tgcaggaggc gcgccgatgc gcggtcatcc gaacagggga tcaggctggt ggatgaaaca 894001 aagctcatgg agctacagct ggacggtggc tcactctatg aaaatgtatt tgtcgaattc 894061 aaaggccgga ctgcgtgcgg tgcgggtgaa atcagcggaa gaactgatgc cgggcgatgt 894121 gatttgctat gacttcgaag gagacggccg gtttaatcat acaacgattg tcgtggcaaa 894181 ggacaaaggc aatatgccgc ttgtcaacgc ccagacttat gacagcagga tgaggtattg 894241 gtcatatgag gattctacgg catacacgcc gtcaatacga tatgcctttt ttcatatcgt 894301 tgatgatacg acaaaagagt aattaatgtt ataatgatgg gcggataaga aaaacagagg 894361 tgaacattgt ggcattacat gtcgttttat atcaaccaga aattcccgct aacacaggga 894421 atattgcacg tacttgtgca gcaaccaata caacgctaca cctgattcgt ccgctcggct 894481 tttcaacgga tgataaaatg ctgaagcgtg ccggactcga ttattgggag tttgttaacg 894541 ttgtgtatca tgattcgtta gaagaattgt ttgaggcata taaaaaaggc aagtttttct 894601 ttattacaaa atttggccag cagcctcata catcatttga ttacactgat cttgacgagg 894661 attatttctt cgtgttcgga agagaaacaa gcggtttgcc aaaggattta attcaaaata 894721 atatggaccg ctgcctgcgt cttccgatga cagagcatgt cagatcgtta aatctgtcca 894781 atactgccgc gattcttgtt tatgaagcgc tgcgccagca aaattaccgt gatttaaaat 894841 agtgaaaaac ccgctcatcg atgatgggcg ggtttttttg cggatgttga aatgctttgt 894901 ttcgtttttg ggcttaacaa cgtaacagtg ttatgttaca atgtacccat caaaggagct 894961 ggacttatgg aagaacaatt aatctctaaa aaagaattac ttgaaagaac atcgatttca 895021 tacggtcagc tgtatcgatg gaagcggaaa aacttaatac ctgaggaatg gtttattcgt 895081 aaatccacat ttacagggca agagacgttt tttccgagag aggagatttt aaaacgtata 895141 tcaatgattc aaaagatgaa agaaaatttg tctttggatg aaatgaggga aatgctgtcg 895201 ccgaaaatga aggatgtcag catgaccgct gatgaattgc ttcataaagg tttggtttca 895261 aggcctgctc ttgaagccta ttcagaagac ggaggaagtc cggttttttc atccagcgat 895321 ttgctttcgc tgtttgtgct tgagggcctg ctgcagtctg gaaatgtcag ccttgcagaa 895381 gcaaaaatgg ctgcagaggt attaaagaag catgatactg aagagattga aaaacagacg 895441 gagctgattg tgctccgcaa gctcggtgtc acaacttgtt ttatagcggc tgcggcggac 895501 agcattttgt ttgaatcatc cgtaaaggtt gtggaacggg tagatttatt aaaagcttca 895561 gaggaattaa aaacaacatt tatgcaggag ggccatcaat ggatgtagtg gaaaagctgg 895621 tgataaatgg atcaggaagt tctaagggag gaacatttca atcagttgag attaatggca 895681 gcgggacagt ggccggggac gtggagtgtg acactttttc ttttaatgga aacggaaaag 895741 cggacggcag cgtcaaagcg aaagcggtaa ctatcagcgg ttcaggaaag atacatggag 895801 acgttgaagc agaatctatc cggatgaatg gcactggttt tattcaagga gaggtatctg 895861 caaaacaatt gaaaatcgct ggatcatcaa catttggcgg cactgtcaag gctgatggaa 895921 ttgacattag cggaaaagct gtcatggaag cagattgtga aacagaaacc tttcaatcag 895981 aagggaaatg caaaatcagc gggcttttaa atgcagacca ggtgatcatt aagctttctg 896041 caggggaaag ctatgcgcgg gagatcggct gccgccatct tcaagtgacc tgcagaaaag 896101 gaatgctgac attgctcaga ttgatgccgc agcctgttct aacagcagag ctgatcgaag 896161 gtgacgtgat tgaattgaca aatacaaagg cgaaaaccgt gcgcggtaat aaagtgatca 896221 tcggcccgga ttgccagatt gaaaccgtcg aatacagcgg ggactatacc tgtgatccaa 896281 gcgcgtcggt tgaaacatcc acaaagttgt aaggaggatc gtaatggaga caacaaaact 896341 gggaaattta aaattatatg gcgctgggca tgccgcagga ggcgcgtatc acaatgtcag 896401 catcaaagga gaaggtatag ttggagaagg gctgtctgct gtaggctgcc gcatatacgg 896461 aacgggcctt tttctcggaa aagcagagac tgagcggctg cgtgtgctcg gagaaagtga 896521 atgtaaaggc gatctgacag ccggcaaaat caatatatat gggacaatga aagtcagcgg 896581 ctcacttcaa tttgatcgat tcaatctgaa aggccagact gaaattggcg ggaatatgac 896641 tggagaatcc tgcgatgtga aagggaagct tagcgtaata ggtgattgtg aaacagaaat 896701 gttccatgtc acaggctgtg ttgatgtatc ggggttatta aattcgggtg agatcaagct 896761 gggattgagc catgatataa gccatgtgca ggaaatcggc ggaacaacaa ttacagtgaa 896821 aagacgcgcg agttttttta gccggaagaa agggaagctg atcgccgatg tcatagaagg 896881 agatcgggtt tatttggaga ataccgaagc ggcagttgtc aggggaaaag aagtgatcat 896941 cgggccggga tgcagcatcg gaacgattga gtacgaatac aaatgtgaat gcgatccgca 897001 ttcacagatt aaagaaaaaa caaaactgta aaacattgtt ctgttataca aaaagggtgc 897061 tctttcagga gcaccctttt ttattctttt ccaggcttgc tttcgtatcc tgcggtaaaa 897121 attgatacta aaaaagtgac aatgacaccc atcatgatga ttgttttcac cgtctctccc 897181 cctcttcaat ttttccgtgc tgtccgagtc tggatgattc tgtatttttc tttattatga 897241 acggtcgcag tctgccttgt caacgatgta tgagtatctt tatttttaag aaaccaaagc 897301 atgtatcacg agatggcggc atagattgta tcaaagtacc ttatttgcat agtgtatcaa 897361 acatgataga ggaggtcctt atggatatat taaagaaaat tgaaaagtac agagaggaag 897421 agcagcggct gaaatgggaa ggaactttcg ccgattattt ggagattatt aaagaaaatc 897481 cgatggtcgc gcaatctgct cattctcgag tttttaatat gataaaagac agcgggatag 897541 aggagattga cggacgcaag aagtacagtt tttttgaccg cgagctgttc gggcttgaag 897601 aatctctgga gcgtcttgtg gaagagtatt ttcatccggc tgccaaacgt ctagatgtca 897661 gaaagcggat tctattgctg atggggcctg tgagcggcgg taaatccacg ctggtcacaa 897721 tgcttaaaaa aggtctcgaa gcgtacacgc tgacagataa tggcgctgta tatgcgatta 897781 aaggctgccc gatgcacgag gaccctctac atttaatccc ccatcattta cgcgatgact 897841 tttacagaga atacggcatt agaatagaag gaagtctttc tcctttaaat gtcatgaggc 897901 tggaggaaga gtacggagga agaattgagg atgtgaaggt ggagcgcatc ttcttttcag 897961 aagataagcg tacgggaatt ggaacattca gtccctctga tccgaaatct caggatattg 898021 ccgatttgac ggggagtatt gatttctcaa caatcgccga gtacggttca gaatcagatc 898081 cgcgcgctta tcgatttgac ggagagctga ataaagcgaa ccgcgggatg atggagtttc 898141 aggagatgct gaaatgtgat gagaaatttc tctggcattt gctttccttg acacaggaag 898201 ggaattttaa agctgggcgg tttgcgttaa tttctgctga tgagctgatc gtggctcaca 898261 cgaatgaaac ggagtatcgc tcatttattt ctaataagaa gaatgaagcc ctgcactcaa 898321 gaatcatcgt gatgccggtt ccttataatt taaaagtgtc tgaggaagag agaatttatg 898381 aaaaaatgat tgcagaaagc gatgtggcgg atgttcatat tgccccgcat acgttgaagg 898441 tcgccgcgat gttctcaatc cttacccggt taaaagagcc gaagcggtcg gatattgatc 898501 tggtcaagaa aatgagactg tatgatgggg aaagtgtgga aggatataac tctgtcgacg 898561 ttgaggatat gaaaaaagaa tataatgatg aaggcatgag cggaattgat ccgcggtacg 898621 tgatcaaccg gatttcttca acgattatca gaaaaaatat ggaatcgatt aattctctcg 898681 atgtccttcg ctccttaaaa gaaggtcttg atcagcaccc atcaatttca agcgaggaca 898741 gggagcggta tttgaatttt atctctgccg cccgcaagga atatgacgat attgcgaaaa 898801 aggaagttca aaaagcgttt gtttattcat atgaagaatc agcaaaaaca cttatggaca 898861 attacctcga taacgtagag gcctattgca ataaaaacaa gcttcgtgat cctttgacag 898921 gagaggaaat gaaccctgac gaaaagctga tgagatccat cgaagagcag atcggcattt 898981 cggaaaacgc caaaaaagcg ttccgcgaag aaattttaat ccgcatctcg gcctatgcga 899041 gaaaaggcaa gcggtttgat tacaattccc atgaaagact gcgtgaagct attcagaaaa 899101 agctgtttgc tgatctgaag gatgtcgtta aaattacgac ctcaacaaaa acgccggatg 899161 agcagcagct gaaaaaggta aatgaagtcg tggcccgttt aattgatgag cacggctaca 899221 actcgacgag cgccaatgag ctgctgaaat atgtcggcag cctgctgaac cgataagcaa 899281 cgtgacccgt ccgaataggg cgggttattt tgtcccattt tctaaatagt ttgtcaatta 899341 aacgtgcata tgtgcatatg atgaatataa atcttttcaa aagacttgtt tcataatctg 899401 gcacaagccg gaatacgtat gtatcacgac cacaaatggt taaggagggg aattcatgtc 899461 ccaaaatgac agcggccatt ttttgatttc tgaggaaaac tggtccctcc atcgcaaagg 899521 cttcgatgac cagcagcgcc accagaaaaa agtgcaggaa gcgatcaaaa acaatcttcc 899581 ggacctcgta actgaggaaa gcattattat gtctaatgga aaagatgtag tgaagatccc 899641 aatccgttca cttgatgagt ataaaatccg ttataactat gataaaaata aacatgtagg 899701 gcaaggagac ggcgagagcc aggttggaga tgttgtggcc cgggatggat cagacaaaaa 899761 acaagggcct ggaaaagggc agggtgccgg tgatcaggca ggcgaggatt attatgaagc 899821 ggaagtttca ttaatggatt tagaagaagc gctttttaaa gaattagagc ttccgaatct 899881 ccagcaaaaa gagcgggaca atatcattca tacagatatc gagtttaatg atatccgtaa 899941 aacagggtta accggtaata ttgataagaa aagaacgatg atgtcagcct ttaaacgaaa 900001 cgcaatgtca ggaaaaccgt cgttctaccc aatttatccg gaggacctga aatataagac 900061 gtggaatgac atcacaaagc ccgaatcaaa agccgtcgtt ttagccatga tggatacaag 900121 cggcagtatg ggggtttggg aaaaatacat ggccagaagc ttctttttct ggatgacccg 900181 ttttttgcgg acaaaatacg agactgtgga aattgaattt attgcccatc atacagaagc 900241 aagagtggtc tcggaggagg attttttctc aaagggagaa agcggcggaa caatttgttc 900301 ttccgtatat cggaagtcgc ttgagcttat tgatgaaaag tacaatcccg cccgctataa 900361 catttacccg tttcattttt ctgacggtga caacctgaca tctgataacg cgcgctgtgt 900421 gaagctggtc aatgatatta tgaagaaggc caatctgttt tgctacggcg aggtcaatca 900481 gtacaacagg cattcaacgt taatgtctgc atataaaaat gtaaaagatg agaaatttaa 900541 gtactatatt ttaaaacaga aatctgatgt ttttcaggct ctaaagaact ttttcagaaa 900601 tgaagagtct ggtgtaagcc atcaattttc gtaatgaaaa gcccatttca gggctttttt 900661 ttatttaata aaagcaagaa aacgcttgcg aaaaaaatac gggagaaaaa gaaatttttc 900721 ctttgacaaa tcttctttca tttattaata ttttatcttg tgaactatta ttgaggaatg 900781 aggtgaaaag gagttgactg aatcagaacg tgctttgctc acttttgaac agctcttcga 900841 tacgtctcgg gcgatatata aaaaacagaa gaagatattg gagattgtgc ttgagccttt 900901 tgatattaca gtccttcaat atttgctgat gtttaaaatt catcaaagcg gaagcacccc 900961 gctaagcaag ctggcaatgt cgcttgatct taagcctgct tctgtgacgc ggatgacaga 901021 tattctgtat aagcgccaat tgatgaatcg atatgacagt ccggatgacc gccgtatcgt 901081 catgattcag ttaaccgaag agggggaaga actgatagaa aaagccgctg tgcaatatgc 901141 aaaaatgggt gctggcttgt accaaaagct tgatacctcc cagctgcagt atttgcgcaa 901201 actagccgga agtttaacga agcttgctga aggctgttca gaaaaaagcg gtaattaaaa 901261 acttctcaca tattttcacc agctttccgc aaaatgatag aggatgaaac gaaaggagaa 901321 aacaaaatga acagaggacg tttaattctg accaacatta tcggtttgat tgttgttctt 901381 gcaattatag ctggaggtgc ttactactat tatcaaagca caaactacgt aaaaacagat 901441 gaagcaaaag tagcgggcga tatggctgct attactgctc cagcagcagg taaagtatct 901501 gactgggatc tggacgaagg aaaaacagtg aaaaaaggcg acacagttgc aaaaatcaaa 901561 ggtgaacaaa ctgttgacgt aaaatccatt atggatggca caattgtgaa aaacgaagtg 901621 aaaaacggac aaaccgtaca agctggtaca acaattgcac aaacgattga catggacaac 901681 ctatacatca cagcaaatat taaagaaaca gatattgcgg atattgaagt aggaaatagt 901741 gtagacgtag tagttgacgg agaccctgat actacatttg acggtactgt agaagaaatt 901801 ggttatgcga ctaactcaac ttttgatatg cttccttcta caaattcaag cggaaactac 901861 acaaaagtaa cacaaaaagt tcctgtgaaa atttcaatca aaaacccatc tgataaggtg 901921 cttcctggaa tgaatgcatc tgttaaaatt tctgagtaaa acagatcagt catcaaacca 901981 tgaaaggagg ttgtcttaga tggctacagg caaagaaaaa aatgcaaaaa accctatgtc 902041 attgctgatt gtgctaatgg cgggtttatt tttggcaatt ctaaaccaaa cactgcttaa 902101 tgttgcaatg ccgcacttaa tgactgaatt tggcgtaagt gcaacgacga ttcagtggct 902161 gacaacaggt tacatgcttg ttaacggtgt attgattccg ttatctgctt tcctgattac 902221 acgatttggc cagcggagtc tctttctcgt cgcgatgttt tgttttacgc tcggtacgtt 902281 agtctgcggt atcgcaccta acttctctac aatgctgatc ggccgtttga ttcaggccgt 902341 gggcggaggt atcttgcagc cgctcgttat gacaaccatt ctgttaattt tcccgcctga 902401 aagcaggggg aaaggaatgg ggattttcgg gctagcgatg atgtttgctc cagcggtcgg 902461 cccgactctt tccgggtgga ttattgagca ttatacatgg cgcattatgt tttacggact 902521 tgtgccgatc ggcgcaattg ttatcattgt ggctttcttc atctttaaaa atatggtgga 902581 gccgcaaaaa atcaaactcg atactcttgg cgcaatcctc tcgattgtcg gattcgcctc 902641 cttattatac ggagtcagtg aagccggatc tgacggctgg accgacccga ttgtattgtc 902701 tacagttatt atcggagcca ttgcaattgt tgcttttgtt gttcagcaat tgcgtcatga 902761 tgatccgatg cttgatttca gagtgtttaa atatgacatt ttctcactct cgagtgtcat 902821 taatatcatt attacagtgg cactttacac tggtatgttc cttttaccga tttatctgca 902881 aaacctggtc ggctttacgg cgcttcaatc cggtctgctt ctgcttccgg gtgcgatcgt 902941 tatgctgatt atgtcaccga tctcaggtat tttgttcgat aaattcggac cgagaccgct 903001 tgcgattatc gggcttctcg tgacagtggt aacaacgtat caatacacgc aattgacaat 903061 tgatacacca tatacacaca tcatgctgat ctattcaatt cgtgcatttg gtatgtctct 903121 cttaatgatg ccagtcatga cagccgggat gaaccagctt cctgcccgtc tgaacagcca 903181 cggaacggcg atgagtaaca cgcttcgcca aatcagcgga tcaatcggaa caagtttaat 903241 tacgacgatt tatacaaacc ggacgacatt ccattattca caaattgcag ataaaacaag 903301 cacggcggac ccgaacttcc tccatgcgtt ccaaaatgca gtttcgaatt taatggtgaa 903361 tatgaatgtg tcttatgata cggcgaaaac atatgtgtac tcacatattt ataaacacgc 903421 atcactcgat tccaatgtca tggggataaa tgatgccttt atgtgggcaa ccttattctg 903481 tgtagcaggt ttgattttaa gtatcttcct gcgtgacgtc agaaaagata aattgcgtaa 903541 gaagaaaaaa gaggagcttt cattacttcc tgctccaaaa gaagctaagg aatcttaatc 903601 tgtacaggga ggtttcctga atgaaaattt atgtagtgta tgatagtgaa ggcgaacata 903661 ctaaagtgct tgcagaagcg attgctgaag gcgcgagaga aaacgacgcg gctgaagtgt 903721 tcatcgacca tgtagatcag gctgatatcc gcaagcttaa agatatggat gcgattattt 903781 ggggatgccc agggcatttc ggaacaatca gctccggtct taaaacttgg atcgacagac 903841 ttggctactt gtgggctgaa ggcgagctga tcaacaaagt cggtgctgtc ttctgcacaa 903901 cggcaacaac acacggcggc ttggaaatga caatgcacaa tttaatcacg ccgatgttcc 903961 accaaggcat gattgttgtc ggactgcctg gcaacgtgcc tgaaaacgca ctttatggct 904021 cttattacgg agcaggtgtc acttgtccgg tagacagtga tgagttaatg tctgaggaag 904081 gtattcagct tggacgcgcg ttgggaagac gtgtcagcca agtcacagga aacctaacag 904141 caggacagta aggagaggtt gaaatggcca ttattatagc aataattgct gctgtcattg 904201 tcattgcggc ccttattaca tttaacgtcc gcaacgcctc acctggacct gagaagcaag 904261 aagcaaccga tagaatcgca cctccagaag aggaaaaaaa cgaagcgcat taccctgctg 904321 aagcaagggc tgccgagcat acgccatccg ttgtcaaaaa cgattctcca aaagagaagc 904381 gtgacacaat gggtgatgat atttacaggc aggcgctgca aaagtttaag cattctgatg 904441 aagttcatgc agaagaagag gtcactgagg aaagtgacaa aatgcaggac cgcagctatc 904501 gtgatgcgct gctctctatg aaaaataaga aaaagtaatg aaaaaggcaa atccgtttac 904561 tcatgcgggt ttgccttttt tgctgtttcc atcaattatg tttttatcaa ataaatccat 904621 ggaatatgtt gtattccacc ttgatctagt gtactatgtt actcatacac cgaggatttt 904681 ttccgggagg taaagacatg aattcttttt taggtttatt aaagaaagat atcaagcttt 904741 caagaatgtg gctgctagta tggatatgcg gaatcatttt cttattggga acaggccata 904801 ttatagcttc tcgcacgaaa gaacctctag tcatttttgg tttttttgtt gcagttgctt 904861 tttttctgct tttcttatct cctgtttttg ttttttatca ccttcgcaag gaagggaaat 904921 cacagctttg gctgtacaat ccaaatggcg gcttatggct gttttcttct aaattggcag 904981 catctttgct ctatcaattt gtgattcagt tggcattaac agcctatggc atatggatgt 905041 atcatatgct ctctgtaaaa aatctgctgg agcatcaagt tgatataacg agtacagtgg 905101 ctttgctgaa tatgtatggg cttatttctt cgttagatat gtcagtaaca gtcattgtgt 905161 tttggactgt ttttcactct ctcagaaatt ggcgcggaat gcggtgggct gcgatggttc 905221 tgttggtcgc aatgtggtta ttcttcgatg aatacatcat aagccctttg gttgaatctc 905281 aaaagcattt ctggcctgta acagtctatt gcaattttga tttccacttc cacaatgttt 905341 ggagattgga actaaaacct atccatctgt ctgtgctagg gtttcctatt gctatagtca 905401 tcacattctt gctgctcatc atggcttcaa aactgcttga tcgtaaagta gaggtgtaaa 905461 tatggacaat caattccaat cctcgaaacc gatttatctg cagatcgctg atcagatctt 905521 ttataggctg gtcaggaagg agctgctccc aggagacaag cttccttcag taagagaaat 905581 ggcgattcaa actaaagtaa atcccaatac aattcaaaga acttacagtg agatggaaag 905641 gctgggtatt gtggagacaa gaagaggtca agggacgttt attgcggaaa aagcagaaat 905701 cgtagacgag ctgaaagaca agctgacacg agaggtgctg gaaggctttg tcaagcaaat 905761 gaaagagctg gggctaacga aagaagaaat gttagaaggg attaaaacat tcacagaggg 905821 aggctaaaat ggaaatcaag ctagaacatg tatcaaaaaa atacggccgc catacggccg 905881 tcaatgatgt gtcaatcacc ctatcatccg gacggattta tggcctgatt ggaccgaacg 905941 gcagcggcaa gtcaacgacc ctgaaaatga tggctggcct tctgtttccg acttcaggat 906001 ttgtaaaagt tgatgaagag caggttacga gagaaatggt gcgtcaaacg gcttatctta 906061 ctgagcttga tatgttttat ccgcatttca ctgttaaaga tatggtgaat ttttatcagt 906121 cgcagtttcc tgattttcat acagaacagg tttataagct attgaatgag atgcagctga 906181 atccggaaaa aaagatcaaa aagctatcaa aaggaaatcg gggcaggctg aaaatcgttc 906241 ttgctttagc gagacgggca gacgtcatct tgcttgatga acctttttcc gggcttgatc 906301 cgatggtcag ggattccatc gtaaacagcc ttgtgtcgta cattgatttt gagcagcaga 906361 ttgtcgtgat cgcgacacat gaaattgatg aaattgagac tttgttagat gaagtaatca 906421 tcctcgccaa tggagaaaaa gttgcgcagc gtgaagtaga agatattcgt gaacaggaag 906481 gcatgtctgt tttgcaatgg tttaaatcaa aaatggaagt ttgctagaaa gaggaggaat 906541 atgatgaaaa cagtgttgga attgaaaaac gtgactaaaa acatcagagg ccgaacgatc 906601 attgatgatc tcagttttac gattcgtgaa ggcgaggtat tcggtttttt aggaccaaac 906661 ggagcgggga aaacgacaac catccggatg atggtggggt taatgaagct gtcgaaaggt 906721 gatgtcctca tttgcggcca atcaattacg aaagaatatg ccaaggcgat taagcatatc 906781 ggagcgatcg ttgagaatcc cgagctgtat aaatttttga gcggatataa aaatctccag 906841 caattcgcaa ggatggtcaa gggtgtcacg aaggaaaaaa ttgatgaagt tgttgaactg 906901 gtcggtttaa cagacagaat ccacgacaag gtgaaaacat attctctggg gatgagacag 906961 cgtcttggct tggcacaatg ccttctgcac gatccgaaag tgctgatttt ggatgaaccg 907021 acaaacggcc ttgatccggc ggggatcaga gaaatcagag atcatttaaa gaagctgacc 907081 cgagaaagag gaatggctgt catcgtttca agccacctgc tgtcagaaat ggaactgatg 907141 tgtgatcgaa ttgcgattct gcaaaaagga aagctgatcg atattcaaaa tgtaaaagat 907201 gaaaacattg atgagaatga tacatatttc ttccaggttg agcagccgag tgaagccgct 907261 actgttttaa atcagtacga tttgctgagt aagacaaatg gtgtagaaat caaactggct 907321 aaagaggaag tccctgcggt tattgaattg ctggtgatgc agcaaatccg tatttatgag 907381 gtcaaggtca taacaaaatc attagaggac cgtttcttag aaatgacagg tgaaacaaaa 907441 gaggaggttc agcatgctta atttgattta taatgagtgg ctcaaaattt tcagccgtgc 907501 cggaacatgg gtgatgatcg gaattctggg gctgacaatg gttggatttg catttttggc 907561 gaatcatttt tctgccggtg aatcaaattc ccattggaaa caagagcttc aagcacaaaa 907621 cgccgaatta aagaaagaaa tcaaagaaga tccttcactg aaagatgggt ataaagaaac 907681 aatcacactc aatgactatc gcatcgagca taatatccct agtgacacgg gctatacggt 907741 atggtcttat gtaacggatt cagcaaactt taccatcctt accggtctgt ttactattat 907801 catcgcggcc ggaattgtcg cgaacgaatt taattgggga acgattaagc tattaatgat 907861 tcggccgctc agtcgttttc aaattttgat gtccaaatat attacagttc tcctgtttgg 907921 gctcctgttg ctgttgattt tatttatcgg ttctacttta ttagggttga tcttcttcgg 907981 aacgggtggt gaaaccgccg cgaatattca tttaatctat aaggatggcc atgtcattga 908041 gcaaaacatg atggggcatt tggctacaac gtatctttct gaatccgtct cggctttaat 908101 ggtggcgacg atggcgttta tgctgtctgc ggtattcaga aacagctctc ttgcggttgg 908161 tttttccatc ttcttgttgg ttgccggtac gactgcaact gcatttattg cagcgaaatt 908221 tgactgggca aagtatatat tgtttgctaa tgtcgacttg actcagtatg tggatggcac 908281 accgttaata aaagggatga ctatgacgtt ttctctcgtc atgctggcga tctactttat 908341 catcttcctg ttgcttgctt tcggaatctt catgaagcgg gatattgcaa actaataaaa 908401 aaagctgttt tgcttatgca aaacagcttt tttgtcaaaa taaaaactgc aggtttgcac 908461 ctgcagtttt tcatatcaat ttatgcttac gcttctttag taacgttagc agcttgtggt 908521 ccgcggtttc cttcaacgat ttcaaaagaa acagcttggc cttcttctaa agttttgaag 908581 ccttcgcctt gaatagcaga gaaatgaacg aatacatcgt cttgaccttc tacttcgatg 908641 aatccgaaac ctttttcaga gttgaaccat tttactttac cttctaacat gaaatttcct 908701 cctaaagcga tcataacgct taaattcact attcttgctc ttaacaaact ttcaagacga 908761 aaactcttac aaaactttct tcttaaagat agttcgaaca aaaataatta cctttactct 908821 accagtaatc ttcagaaaaa acaactgctt attgaaattt ttttcggaaa ataccatatt 908881 tatttttcaa tttgatattt atttacggaa attcatctgt tttctcgata tgtgatcata 908941 cgtttgcctt agtattcctt cattttggga agataagtaa taggaattga caaccttatt 909001 ggatatgagt aaggtaaaag ttaatcaata ttacaaatga caacgtttat caactaagag 909061 agcgtatgat ttttatgtct gatattgctt gcatgctcta atacatagat aggagtatgg 909121 tcacaatgaa aaagtggctt atatgcagtt tcgtccttgt tcttctcgtt tcatttactg 909181 catgttcacc gtctgcagaa catgaatcga taaaaatcgg gattgctgag tctgacgggg 909241 caatatggaa ctatattgct caaaaggctg aagaggcagg gctggatatt cagctgatcc 909301 ctttttctga ttatgcggag tctgatatcg cacttgctaa caaagaaatt gatgccaacg 909361 cctttcaaac catttcatat tttcagtcgt tcactgaaaa atacaaactt aatttggcac 909421 cgctcgggac gacatacata acgcccatgg gcatttattc aaaacgatat gaacgaatcc 909481 gagatatatc gcggggagct gtcgtttctg ttccggataa agcgttcgat tttggcaggg 909541 cgcttacggt gctccaggaa gcgggtttgc taacgctgaa aaacggattt aacggaacag 909601 gttcagttga tatgattaaa gataatccga gacacctgaa attaaaagct gtccggcaac 909661 aggatgcagt gagcggtgcc gacgtgtttg tcatgaaacc atcagaagca aaaaaagcgg 909721 gcttgaaccc gaaaaagcat acgctaaaga gcggcggact catgtctgag gaagagatga 909781 atttgattgt tgtcagagcg gaggatcaag atcgggaagc gctgcaaacc attcttgagc 909841 tttatcaagc tgatgataca gcggcattta tagaaaaaga atatcaggga gatcttgtcc 909901 cggcttttct gcctttgaaa cgtctttcag attggaagaa tgaattcgaa cattgaattc 909961 attctttttt ttctgaaaaa cacactctgt tccgtcccgt ttctttcgct ttgtaaagca 910021 tttgatcggc aagaatgggc aaggatcctg gctgttccgt attattgggg taatgagcgg 910081 cccctagtga tatcgtaact gaaagctcgt cgccgtttgt taatacaatc ggtgcatcac 910141 ttacagtgct cctgatccgt tcagcgatcc gggctgcttt atcaagagaa cagttcggca 910201 ggagcacggc aaattcttca ccgccgatcc gagcggcagg atcagtattt cggatggtct 910261 gcttcagacg taaccctagc tctttgagca cctgatctcc ttcatgatgg ccatattggt 910321 cattgatggt cttaaaatga tcgatatcca tataaatcag tgcaaattga aaatgcgggg 910381 tatcggccgc ctgctgatac agagcttttg tggtttcttc aaattttctt cggttataca 910441 cgcctgttaa aaagtcaaag tgcgcctgaa acttatattg tttaaaaaga agatgtgcat 910501 ttgtttcatg atcaataata tataaactga gcatgccgcc cgctattgat atgatccaaa 910561 aatacaaatg aagttcgtat gaatgtaaat ctataagaaa ataaaaggaa aaggagatca 910621 agctatttgt gattattaaa agatagaaag catgttttag ttgaactttt tttcttctag 910681 aaacaatgag tgacggaatg gcagcgatac aaatgataat aaccgagtat agtgcagatg 910741 tgttcatcgt aatcagcaag cggcctgcag tgatcatggc cagggccgtt gccgttgaaa 910801 cccagcctcc ataaagagcg gcaatcataa tagggatatt tcgaagatca ataattgaat 910861 gctgataggt aaatccaaaa accatcagaa taaccccgag caaaccgcag gccagtcctt 910921 taacagcttg aaaggatatg ctgtcttttt tatgtactag cctttcttta aacaggtggg 910981 tgaagagata attaaatgtg attaaaatgg tcaaatttac aaacagttct ttcagcaaat 911041 attatcaccc ttatataagg tactaaagat ggaagggaaa gaaaagaaca aaaaaggcat 911101 tatataaggt ttttttactt gaattgataa gttaaaataa ttcgcacttg acccatcgga 911161 attagtgtaa tatagtaaat gagaaaattt gaagggagag tttacctgct ttggagactt 911221 tactggttgt attacatgta tttattttat ttttacttat cttagggctc tttgttatgc 911281 agaaaaaaca tgtttccttc tctaaacgtg tatttactgc gctggggctg gggattgtat 911341 tcggatttgc gcttcagctg atttacggcc cgacttcaaa tatagtcatt caaacagccg 911401 actggtttaa tattgccggg ggcggatatg tcaaattgct tcagatggtt gtcatgccgc 911461 tcgtctttat ttcgattctc ggcgccttta caaagctgaa gctgacaaaa aatcttggga 911521 aaatcagcgg tttgattatc gggattttag tagcaacaac agcagttgct gcagctgtcg 911581 gtatcgcgtc cgcgctttca tttgatctgc aggcgattca ggttgaccaa ggaagtacag 911641 agctttcacg gggacaggag cttcagcaga aatcagagga tatgacagcg aaaacgctgc 911701 cgcagcagat tgttgaactg ctgcctggaa acccgttttt agattttacg ggagctagac 911761 cgacttcaac gatcgctgtc gttatttttg ccgctttcct tggagtggca ttcctcggcg 911821 taaaacacaa acagccggaa caggcagaaa catttaaaaa actggttgat gccgtttatg 911881 ccattgtcat gcgtgttgtc acactcattt tgagactgac gccttatggg gtgctggcca 911941 tcatgacaaa aacaattgca acgagtgatc ttgacagcat tctaaaactg ggcatgttcg 912001 tgattgcatc atatgccgcg ttaatcacta tgtttatcat tcatttgctg ctgctgacgt 912061 tcagcggctt gaatccggtg atttatttga aaaaagcggt gcctgtactt gtatttgcat 912121 ttacgtcaag gtctagcgca ggtgctttac cgctgaatat taaaacacag agaagcatgg 912181 gtgtaccgga gggaatcgca aactttgccg gttcgttcgg tctttcgatc ggccaaaatg 912241 gatgtgccgg catttatcct gcgatgctgg cgatgatgat tgctccgact gtcggccaaa 912301 atccatttga cccggtgttt attatcactg ttatcgcagt cgttgccatc agctccttcg 912361 gggttgccgg agtcggcggc ggagcgacat tcgcggcgct tcttgtttta tcatcattaa 912421 acatgcctgt cgcgctcgcc ggtttgttaa tctcaattga accgttaatc gacatggggc 912481 gtactgcttt gaatgtcagc ggaagcatga catccggtct tattacaagt aaggtcacaa 912541 aagaaattga tcaaggggca tttcatgatc aatccagagt gattgaagct gaagaagcgt 912601 aacatatgaa aacgtgtaat ccaagaggat tacacgtttt tttaacggcc aggctctaag 912661 tcctccagca tttccatcat cgtgttgtcg tccatgacat tcattgcgtt ttgttcaaaa 912721 tgaatgggtt cagcataatg cggctgtctt tttttcgcgg ctgtctcagt ttgcctagtt 912781 tgagactgtg tatgctgatg ctgtggttgc tgctgtccag cgtgctggtg ctgacggcca 912841 ttttgccgct ggctttgatg ctgcgaacgg tcctggttat caccgctgct tccgctgctt 912901 ccgctaaatg cttgtttgac catgtttcct acattagaag catcaaacgt gttattttct 912961 gaatttcgtc tgttcatttg tcctgtgata aacccgctga ttctttggcg gatctgaggt 913021 gataatgcag taataagcat agttgatcct atgatcaatg ctgcggggct gattcctctt 913081 cgctggttga acaacatgat ccctcctttg cagtgtattc atattttccc cctcgttaga 913141 caaattaacc gttatatttc ccgggaaagc atttcctcca gatttgcatg cataattaaa 913201 gccagttaga aaaacctata agtaaagtga taaaggagga attcacatgt ttggaaaaaa 913261 acaagtcctt gcgtctgtgc ttcttatccc tttgcttatg actggctgcg gtgtagccga 913321 ccaaggtgag ggcagacgtg ataataatga tgtaagaaac gtaaattatc gaaatccggc 913381 caatgacgat atgcggaatg taaacaatcg ggataacgtt gacaacaatg ttaatgataa 913441 tgtcaataac aatcgtgtaa atgacgataa taacaacgac cgaaaacttg aggttgctga 913501 tgaagcagct gataaagtaa cagacctaaa agaagtaaag catgccgata tcattgtggc 913561 tggaaatcaa gcctacgttg cagtcgtttt aaccaatgga aataaaggtg cagtagaaaa 913621 caatctgaag aaaaaaatag ccaaaaaggt aagatctact gacaaaaaca ttgataatgt 913681 ttacgtttca gctaaccctg attttgtaga gcgtatgcaa ggatatggaa agcgtattca 913741 aaatggtgac ccaatcgccg gattatttga tgaatttaca caaactgtac agcgtgtatt 913801 ccctaacgct gaataaatga aagaagccgc acaatttgtg cggctttttc tttgcgttaa 913861 tgacacactg cgaactcagg ctgcatagag taaaaataaa aaggtacaag acggaccggc 913921 tcagggaggg agacgtttgc gggatggcat aggaaagcgt gcggcatccg ctctattcct 913981 gtgcggagtc cttgtgatgc tggctgtaag ctcagccatc gtatcaagcg cgatgtatat 914041 cctgtctttt ccaggtcagg catctggaat aacaaaagaa caagtgacga agcacatgaa 914101 gaaagagtca ttcaaacagg ccgatattta ttacacttct aaggaaaagt ccttactgcc 914161 attgacgaaa gaaacgcttg aatatgcggt cagtattaat cagattatga ttggatattc 914221 gaatcaaaag cctattgaca ttattttttt tcctaatgaa aaacagatgg aggcttactc 914281 cggtttattg gatgtagttg gtttttattc tgaacgggag cagctgatcg gattgttgcc 914341 tgaagagaaa aagaaactgt tagaagggga cgaggtagcg gtttatttgt accagagatt 914401 gttgattcat gaatactcgc accatgcgtt tcaccagaaa ttgaaggagc ttgagacgga 914461 tcccgatgag tttccgttat ggtttcatga agggttaagc gagtggattg cgaactatga 914521 attgctcata gatccgatca cgttttctgt cgtgcccttt gaccgtttgc agactgatcg 914581 agactggcag gaagctagag ccgaatatga cactgatgtc tatttgcaaa gcttttatat 914641 gatcgatgag ctgacggaca aatacgggaa agacattatt tcagaaatga ttaaggaaac 914701 ggcaaaaaaa ggggactttg aaaaagggtt taaatcagca acaaaggaaa gtcttgatca 914761 atttgaaaaa gattttaaga aaaaatttga aaaaaacagt gcggcattgg atagtatcta 914821 tccaatgcct ttgttattag tgaagtcctt gctgacccat tccgccttgt gtcggaggca 914881 tttgtccttg ggcaggggcg aatgaatttc gcagctgttc catatcctgc gcatcaagct 914941 gaggaacctg gtaatagccg tgtttgtttt ggtataggaa aatttcaaat gccatttcaa 915001 catactcctg aatttgcgca gacagtacgc gtcttacggc cggatttgtc atttccagag 915061 aagccatcgt cagcatagaa gcttgtgctt taatcgcgca aagcatttgt cggctgatga 915121 tgctgtcatc aatatcattc atggattgaa caggtttttt aggctgtgac ggctgcatgc 915181 cgtaaacagt ctggttgtct tccttcatca tataagttgc tgttttttgt gaaggttcgc 915241 ttcctgtttt gaagcattct gcagttatat tgtattgaga tgtgatgaat tgatgttgac 915301 gatcaaggat gtttagtaat tcttgatcct tacagaattg tctcagcatc ataaactgat 915361 caagcacagt aagtgttccg gaaagcacct catgcatatc aaacatttca tgtccgccgt 915421 ggtttttatg cggtttgcca ggaatacctt tgttcatttg ggattgctgc tgctgattga 915481 actgatccaa accgaattcc tccttttttt tcagatcagc tgtattttgt gtcagtctgc 915541 cgtgtattat gcagaagcct gaaaggaatt atatgctgtc tgtcgaaatg ataagcagac 915601 aaaatcgttg tcattatgtg tataagggag gaaatatgat gaggcgtatt ctgcatattg 915661 tgttgatcac ggcattaatg ttcttaaatg taatgtacac gttcgaagct gtaaaggcag 915721 ctgaaccgca acagcctata tcgattgaga aggcaataca gcaaaaagaa ggacaggcac 915781 ttgtcgaagg atatgcagtc ggccaggctg tttccccgca gcattataaa ctgacaagcc 915841 ctttttcaaa tgattataat gttgcgctgg cagaccgtaa aaacaaaaca tcgcccgaac 915901 acatccttcc tgtgcaaatc ccctccgcct tcagaagcca atttgggctg caaaccaatc 915961 cgcttcttct tgggaaaaag ataacggttc aaggaaagct tgaaaattac tttaacacga 916021 caggacttaa aaacgttcag tcgatgaacg taaccgatga cacaaaaact ccgccggctg 916081 aacagcaagt gaccataaat gaagcacggg gaaggctgaa tgaagaagta acgataaaag 916141 ggatcattac agctgatcaa aacgcaatcg gaggcgggaa gctgtcgacc tttttgcaag 916201 atgaaaccgg aggcattaac atttattcgc catcccctga acaatttccc gaattaaaag 916261 agggtatgga tgtcacggtg acagggaaaa tcacgtctta ccaggggctg aaagaaatcg 916321 ttccaaactc atcaggcatc aaaatcaacc agtcaaatca atccctcccc gcccccaaac 916381 acttaacaat caatgaactt attaacggca gcctaggtga tcagtatgaa ggacgccttg 916441 tgaaactaac cgcttttgtt tcctcaattc caagttctcc tgccggcggc ggttacaatg 916501 taacaatgat tgatgacgac catcatgcaa tgacgctccg ggttatgaat gaaacagggg 916561 tgataaacga gcttgatgag ggcaaatggt atgaatttac cggtgtgtta agcagatacc 916621 aaacctttca gctgcttccg cgaaaatcgg ctgacctgaa gctgcttgaa gagcagcccg 916681 cacctccgtc tgcagaggga gaatatgaag ggattgttga ccgggtagtt gacggcgata 916741 ccattcatct taaatctccg gtgcttggaa cgacaaaaat ccggtttgta aatgtagatg 916801 cacccgaaac atatcacaca ccaaaaaatg acgcagatga aaatcaatta agatttggca 916861 aaaaagcatc tgactatcta aaaacggttc tgtccccggg tgataaaatt actgtcaagg 916921 tcgggagtga agccaaggac agctatggca gattgctcgg acaagtcata accgaatcag 916981 gttcaaacgt gaacttagag cttgtaaaaa acggctatgc tccgacgtat tttatttggc 917041 cggttgacaa tgaagaggat tatcagcaat ttcaggccgc agtagccgct gcaaaaaaag 917101 atcaaaaagg aatttggaat gaaaacgatc ccctcatgga aatgccgttt gaattcagag 917161 ccagagagca agggaaaggc ctgacaagat atgtggggga ctcgtcgaat aaaacatatg 917221 tgcagccagc tgactggaag aagatagctg tggaaaacag aattttcttc gcctcagcaa 917281 gtgaagcgga gagcgcggga tataaaaaaa ggcaaacggc acctcaagaa catgtgccgc 917341 ttagaattct cagcatgaat gatttgcatg gcaaaatcga tcagcaatat gagcttgatc 917401 ttgatggaaa tggaactgta gacggcacgt ttggacgcat ggattatgcc gccgcatatt 917461 taaaagaaaa aaaggctgaa aagaaaaact cgctgattgt gcacgcggga gatatgatcg 917521 gcggaagctc tccagtttcc tctcttcttc aggatgaacc gactgtagaa ctgatggagg 917581 acatcggatt tgatgtcgga accgtgggaa accacgaatt tgatgaaggc acggatgaac 917641 ttctgaggat cttaaatggc ggtgatcatc cgaaaggcac aagcggatat gatggacaga 917701 actttcccct tgtatgtgcc aattgtaaaa tgaaatcaac tggagagccc tttttgccgg 917761 cttacgacat cattaatgtg gagggcgtac ccgttgcttt tatcggagtt gtcacacagt 917821 cggcagctgg catggttatg cctgaaggaa taaaaaatat cgagtttaca gatgaagcaa 917881 cagcggtgaa taaggcggcc gaagagctca agaaaaaagg cgtgaaggcc atcgcggttc 917941 tcgcacatat gtcagctgaa caaaacggca acgccattac cggtgagtct gctgatcttg 918001 caaacaaaac agattctgaa attgacgtga tttttgccgc gcataatcat caggttgtta 918061 acggtgaagt gaatggaaaa ctgattgttc aagcgtttga atatggaaaa gcgataggtg 918121 tcgttgatgt agagatcgat aaaacgacaa aagacattgt caaaaagtcc gcggaaatcg 918181 tatatgttga tcaaagtaaa atcgaaccgg atgtcagcgc gtcagccatt ttaaagaaat 918241 acgaaacaat tgcggaaccg attatcagcg aggtagtcgg cgaagccgct gttgatatgg 918301 aaggggggta ttcaaatgac ggcgatacac ctcttggaaa cctgattgcg gatggtatga 918361 gagctgccat gaaaacggat tttgccctta tgaatggcgg cggcatacgt gaagcgctga 918421 agaagggtcc aattacgtgg ggagatcttt acaatattca gccgtttgga aatgtgttaa 918481 cgaagcttga gattaaagga aaagatttaa gagagattat caatgcgcaa atctcgccgg 918541 tttttgggcc tgactacagc atcagcgggt ttacgtatac gtgggataaa gaaaccggaa 918601 aagcagttga tatgaaaatg gcagatggca ccgagatcca gcccgatgcc acatatacat 918661 tgaccgtcaa caactttatg gcgacggcga caggagccaa atatcagcca atcggactgc 918721 tgggaaaaaa tccggtgaca gggcctgagg atttggaagc gacagttgag tacgtgaaga 918781 gttttgatga gccaattgcg tatacaaaag agggaagaat taagcttgct gaagccagtg 918841 atattgaaga ccctgtaaca gaagacccga taacggaaga gcctggagat gatccgggga 918901 cggaggatcc gattaaagag gatccaaggc caggtgaaga tttgcctgat ataaaagaaa 918961 ctccgggaac agcaccggtt catcagcttc cgccttcagc catttcgaga ttcaatgaaa 919021 taccaatcaa caacacaaaa accgctgata ctgctaatag catcagcaca ttgccgttac 919081 aaaccgagac tgcggaaagc gggtctgatc atcagcttcc ggatacgtca gcgggctact 919141 ataactttat ggtaatcggt gcggcggtga cattgtcagg aacttatcta tatgtcagaa 919201 gaaaaaggag cgcctccaga acgtgaaaaa agttattcca ctattcatca ttgctgccgg 919261 cctagtgatc gcaggctatg gaggctttaa attgatcgat acgaatacga aaacggaaca 919321 gacattaaaa gaagcaaagc tggcggctaa aaagccgcag gaagcttcgg ggacgaaaaa 919381 tagcacagat caagcaaaga acaaagcatc atttaagcct gagaccggcc aagcgagcgg 919441 cattttagaa ataccgaaaa tcaatgcaga gcttccgatc gtggagggca ccgatgctga 919501 tgatttagaa aaaggtgtcg ggcattacaa ggacagctat tatcctgatg aaaacggaca 919561 aattgtgctg tcagggcatc gggataccgt gtttcgccgg acgggagagc tggaaaaggg 919621 ggatcagctc cgtcttctcc tgtcatatgg agaattcaca tatgaaattg taaaaacaaa 919681 aattgtcgat aaggatgaca catctattat cacgctccag catgaaaagg aagagctgat 919741 tctgacgacc tgctatccgt tttcatacgt cggaaatgcc ccgaagcgct atattatata 919801 tggaaaacga gtgacttaaa aagccgaggc agtgcctgcg gcttttcttc atgaaaaata 919861 tgtgcggcaa aggtttttca tatcagcagg gaaaggggct tcagcaacta tgagctcgtc 919921 tgttatcggg tgaaccgctt gtactttatt ggcgtgcagt gcctgcctgt ttagcagctt 919981 gctcccgcct ccgtaaagcg agtctcctgt caacggatgg ccgaggctcg ccagatgaac 920041 acggatttgg tgtgttctgc ctgtttccag ctctaattca acgagcgaca gccgttcttt 920101 cgcattgctg gccattacct tgaaatgagt gacggctgtt tgcccgcctg gtgaaacccg 920161 gcgtcttgtc gggtgtgagc ggtctctgcc gatcggtgaa ttaattgtcc cttttttcgt 920221 ccgtagctta ccttcagcga tagcggtata cgtacgcttc agcgtctttt tctctaactg 920281 ctggtctaag atggcgtgtg ccaaacgatg cttggcaaaa acgatagcgc cagatgtatc 920341 ctgatcaaga cgatggacgt ggcgcacctt acatgtttcg ccatttatct gataatgata 920401 cgcgatcaaa ttagccagtg tgccggtttg cccatcctca ttcggatgcg tcgcgatgcc 920461 agcgggttta ttgatgatga gcatatgatt gtcctcaaat aaaatatcaa gctcgccata 920521 ctccggaatg accgaagatg cttcactttc ctgaagatca atgaacacgc ggtctccctt 920581 ttttacaatc atattgttta agacggattc gtgattgacc tttatctgtt gatgggacat 920641 ccagtcttgt atcactggtt tagaagcttt gagcgctgtt ttgagtacgg aaaacagcca 920701 ttggccgtcc tgtttttcat tgatgaggat ctcaagccct ctgccttttt ggttcatgtt 920761 aaatggctcc ttttcgaagc ggaaggctgc tgtttctcat aggaaacact taccttagct 920821 ttcgcgtttt tttctgtgct attcttgagt aagacttagg atattcgatg gcaagaaagg 920881 tgattgacgt gagaattgtg aacgcagcaa ctgcagaaca ggagagcttt atcaaggagc 920941 tgtctatgga gctgatccat gatgtatttc ctctttattt ctccgaactg gacattcagc 921001 gctttaaaaa gaaaggcgtt ctgtctttaa ataaccatta ttaccaagga acattaaaag 921061 aagcatttca aattatggct tgtctgcaaa tgatacatat tatcctgacc aagccttcgc 921121 cgcactctga tttgagtgat caggcgattt ttgaaaaaaa cagcaagatg ctgaatgatt 921181 ttgggattta ttttccgttt gctttttctg actttcaaaa gaagactaac aaagcctttt 921241 tcggtcaaag aaggctgata taatcatgcg gcaagggctt ttctattttt agaaaagctc 921301 tttttgtatc agagaaatca tatcataaaa cctttcctct aactcccttt ttaaacggct 921361 cgtgtctgaa catactaatg attgaaaggg gtgctgacaa tgagttcagt taaagataca 921421 atgacaacgc aggtggcaac cgtttctccg aatcaaacga ttcaggaagc ggcttctcta 921481 atgaaacagc ataacgtcgg ggcgatcccc gttgtagagc aaggtgtttt aaaaggaatg 921541 ctgactgacc gtgacattgc attaagaact acagctcagg gccgtgatgg ccagacaccc 921601 gtttcagaag tgatgtcaac agaactcgta tcaggaaacc ctaatatgag tctggaagac 921661 gcgtcgcagc tgatggccca gcaccaaatc cgccgccttc ctattgtaga tcaaaacaat 921721 ctagtcggga tcgttgcgct tggagacctg gcagtcaatc agatgtcgaa cgagtctgcg 921781 ggatcagcgc tgacaaacat ttctcaccaa aacattcatt aataagaaag agcttgcagt 921841 gtgcaggctc tttcttcaca taaaacctta ctttttgaaa gcagacttgt ttcggggtat 921901 agtgagtgta tacatatgtc tcaattcgta ctaaaggagt tgtacccagt gattaaagcg 921961 ttaatttttg attttgacgg gcttattcta gatacagaaa cacacgaata tgaggttctt 922021 caggaaatat ttgaagagca cggctcagtg ctgccgctat ctgtctgggg aaaggtcatc 922081 ggaactgctg cgggtttccg gccttttgaa tatttagaag agcagatcgg gaaaaagctg 922141 aaccatgaag agctcacaca attgagaaga gagcggtttg ccaaacgcat ggaatcagaa 922201 aaagcgagac ctggtgtcga agcgtatttg aatgcggcaa aggatttagg cttaaaaata 922261 ggccttgcct ccagctctga ttataaatgg gtgtccggcc atttgaagca aatcggcctg 922321 tttgatgatt ttgaagttat tcaaacggcg gatgatgtgg aagaggtgaa gccgaatcct 922381 gaactctatt tattggcggc aaagaacctg ggggtatcgc cagcggaatg tctcgcgttt 922441 gaggattctg tcaatggttc gattgctgcg aaacgtgcag gcatgaagtg tgtcattgtc 922501 ccgaataaag taacgggtac cttgatgttt gaagactatg atcacaggct tgaatcaatg 922561 gcggagatgg agctcgccct attgcttgat catctgaact cacaaaacta gaaaggagcg 922621 agtaggttgt ctgagaaatt agatttgacc cggtttgaaa agaaaatggt tatccgcaat 922681 atcgaagaga aagacatcga caagattatc gatcttcaaa aggactgctt tccaggaatg 922741 gagccttgga agcgggagca tttaatcagc catttggagc attttccgga aggacagttt 922801 tgtgcagaat tcgaaggtga aattatcggt tcgtgctcaa gtctcctgat taactttgat 922861 gaatatgatg accgccatac gtggcaggac attacagatg acggttatat caccaaccat 922921 aatcctgacg gcttgaatat gtacggaatt gaagtcatgg tgcacccgaa atacagacga 922981 atgaagatcg gccaccgttt gtacgaggcg agaaaggact tagccagacg cttaaacctg 923041 aaaagcatca tcataggcgg acggattcca aactatcaca aatatgcaga ggaaatgaca 923101 gcgagagagt atgttgaaca ggtgacacgc caccaaattt acgatccggt tctttctttt 923161 cagctgatga acggctttac ccttatgcga attaacccga actatctccc ggatgataca 923221 gcttcgatca agtatgcgac gctgatggaa tggaataatg tcgattatct accgcagcag 923281 acaaaacgct attataaatc ggcgttccct gttagaattt gtgtgatcca atacgaaatg 923341 aagaaaattt attcctttga ggaatttgcg aatcaagtag aatactatgt cgatgttgct 923401 tccgacgcaa gatctgattt tgcggtgttc ccggaaattt tcacaaccca gctgatgtcc 923461 ttccttgagg aacggtcacc gagcttggcg gtgcagagaa ttaccgagta tacagaagat 923521 tacatcagcc tgtttactga cttggctgtg aagtataacg tcaacattat cggcggatct 923581 catttcgtcg aagaggaagg caagatctat aatatcgctt acctgttcag acgggacgga 923641 acgatcgaga agcaatacaa actccatatt acgccgaatg aacgcaaatg gtgggggatc 923701 agcgcaggag accaagttcg cgtgtttgat acggactgcg ggaaaatcgc gatccagatc 923761 tgttatgaca ttgaatttcc tgagcttgcc cggattgcgg ctgataaagg agccaaaatc 923821 atctttacgc cattttgtac agaagaccgt caaggctatc tgcgtgtcag atactgttcg 923881 caggctagag cggttgaaaa tcaaatttat acggttatct ctggaacggt cggaaacctt 923941 ccgcaaacgg aaaacatgga tatccaatac gcccagtcag gcatctttgc cccgtctgat 924001 tttgaattcg cccgagacgg cattgtcggc gaaacaaacc cgaatattga aatggtcgtc 924061 atcggcgatg ttgacctgga aattctcaga agacagcgcc aaaacggtac agtgcgccag 924121 ctaaaagaca gacgacgtga tatttatcat attcaatata aaaaataatt cccaaaaaac 924181 ccgcctgaat tggcgggttt ttttaaacaa aagcggaatt gtttaggtgc tttctttaaa 924241 ataaaagtaa attgtatagt ggatgtgcct tatggagttt ctgtattttc gccatttcct 924301 atatcataca gaaaacggct aggcttcaca ttgctattgc aatggctgtc caagttgttt 924361 cgagtgcgac ctttatcagt acgatgctga gcattgtcac tttgcctgtt ttgctttgga 924421 agctgcatcc tctttcttct tgagaaaggg gatgttttat tatttacgcg gtttattgac 924481 tctgacccgg tctggcttta tattgaaggc agggaaatca tcaccaagac atcacataaa 924541 gagaaggtct gtttcaattg aattggcatt atagggaacg ctaatgaaat ggagatgatg 924601 gggatggaaa acattcagca aaatcaggga ttaaagcaaa aagatgagca atttgtgtgg 924661 catgccatga agggagcgca tcaagcggac agcctgatag cccagaaggc cgaaggggcc 924721 tgggtaaccg acacagacgg acgccgctat ttggatgcga tgtccggttt gtggtgcgtc 924781 aacattggtt acggcagaaa ggagcttgcg gaggctgcct atgagcaact aaaggagctg 924841 ccttactacc cgttaacgca aagtcacgca cccgcaattc aactggcgga aaagctgaat 924901 gaatggcttg gcggcgatta tgttattttt ttttccaaca gcggatcgga agcaaacgaa 924961 actgctttta aaattgcccg ccagtaccat ctgcaaaacg gcgaccacag ccgttataaa 925021 ttcatctcaa gatatcgggc ataccacggc aatacattgg gagcgctctc agctaccgga 925081 caggcgcagc ggaaatataa atacgagcct ttgagccaag ggttcctgca tgcagctccg 925141 ccagatatat accggaatcc tgatgatgca gacacgcttg aaagcgcaaa tgaaatcgac 925201 cgcatcatga catgggaatt aagcgaaacg attgccgggg tcattatgga gcccatcatt 925261 acaggcggag gcatcctaat gccgccggac ggatatatga agaaggtgga ggacatttgc 925321 cggcgccacg gagccctttt gatttgcgat gaagtgatct gcgggtttgg acggacaggt 925381 gagccgttcg ggtttatgca ctacggtgtg aagcctgata tcattacgat ggcaaaggga 925441 atcacaagcg cgtatctgcc attgtcagcg actgctgtga aacgggacat tttcgaagcg 925501 tatcaggggg aagctcctta tgaccgtttc cgccacgtga acacgttcgg cggaagcccg 925561 gctgcctgtg ctttggcgtt gaaaaacctg caaattatgg aggacgaaca gctgattcag 925621 cgatcccgtg atcttggagc aaagctttta ggtgagcttc aagctctgag agaacacccg 925681 gcagtcgggg atgttagagg aaaagggctg ctgatcggaa tcgaactcgt caaagacaaa 925741 ttgactaaag agccggctga tgccgccaaa gtaaaccaag tggttgcggc gtgcaaagaa 925801 aaagggctga tcatcggcaa aaacggcgat acagtcgccg gctacaacaa tgtcatccag 925861 cttgcgccgc cattttgcct gacagaagag gacctttcct ttatcgtgaa aacggtgaaa 925921 gaaagctttc aaacgatata atataaaagt gaattattaa aggagcacat gatgagtttt 925981 cacaaccagc cgatcttacc ggctattcgc aatatgaagc aatttgatga gtttttgaac 926041 agttcattct cttacggtgt tattcttgat attcatctcg gccagctgaa gggcgtgatc 926101 aaagaagcgc aaaagcacgg aaagaacatg atggtgcacg tcgatctcat tcaagggatt 926161 aagcatgacg aatacggtgc ggaatttata tgtcaggata tcaagcccgc tgggattatt 926221 tccacaagat cgaatgtgat tgccaaagcg aagcagaaga aaatttatgc cattcagcgc 926281 ctgtttttgc ttgatacaag cgcgatggag aaaagcatgg agtttatcgg caagcataag 926341 cctgacttca tcgaagtgct tcccggcatc gttccgtcac tcattcagga aataaaagag 926401 aaaacaggga ttcccatctt tgccgggggt ttcatccgta cggaagagga tgtagagcag 926461 gcattgaaag cgggggctgt agctgtcaca acatctaata ccaaattgtg gaaaaaatat 926521 gaaaactttt tgacggaaag tgattgacac cgctttcatg cactgataca attgcactag 926581 gttaatacat tgtgatggag aactcggaga ccacagcagc tctttacggc aaatgtttat 926641 gcacccgtaa agcggtttgt tgtggttttt ttattctctt cttctctatc atgcttttta 926701 atcgtgactt taggaggaat gtgctatgac agcattttgg ggagaagtca tcggtacgat 926761 gctgcttatc atttttggtg caggtgtttg tgcaggtgtc aatttaaaga aatcgctttc 926821 attccagtct ggctggattg ttgttgtatt tggatgggga ttgggtgttg ccatggcggc 926881 atacgcggtt ggcggcatca gcggtgccca tttgaatccg gcgctaacga tagcgcttgc 926941 atttgtagga gattttcctt ggaaagaggt tccggtttat attgcggcgc aaatgatcgg 927001 agcgatcatc ggtgcggtga ttatttatct gcattacctc ccgcactgga agtcaacgga 927061 tgatcccgct gccaagctgg gtgttttctc aacagggccc agcattccgc atacatttgc 927121 aaacgtttta agcgaagtga ttgggacatt tgtccttgta cttggaatct tggccatagg 927181 tgcaaatcaa tttacagaag gacttaatcc tttaatcgtc ggtttcctca ttgtagcaat 927241 cggtatttct ctgggaggca ccaccggcta tgctatcaat cctgcacgtg acttaggtcc 927301 gcggatcgcc cacgcttttc ttccgattcc ggggaagggc tcatcaaact ggaaatacgc 927361 atgggttccg gtagtcggcc cgattttagg cggatcattc ggcggtgtat tttacaacgc 927421 tgcatttaaa gggcacatca caagcagctt ctggattgta agcgttatat tggttgtggt 927481 attgttagga ctctatgttt atacgaaatc acattctgct aaaacattat caaattctaa 927541 atatatttaa tcaaagggga gacatcttat ggaaacgtac attttatcct tagatcaggg 927601 gacgacaagt tcaagagcga ttctgtttaa taaagaaggc aaaattgtcc actctgctca 927661 aaaggaattt acacaatact tcccgcatcc tggctgggtt gagcataatg ccaatgaaat 927721 ttggggctct gtcctcgcgg ttatcgcctc agtcatctct gaatcaggaa tcagcgcttc 927781 tcaaattgcc ggcatcggca tcacgaacca gcgcgagacg acggttgtgt gggataaaga 927841 tacaggaagt cctgtctata atgcaatcgt ttggcagtcc agacagacgt ccggcatttg 927901 tgaggaactt cgtgaaaaag gatataatga taaattcaga gaaaaaacag ggcttttaat 927961 cgatccttac ttctccggca cgaaggtgaa gtggatttta gacaatgtgg aaggcgcaag 928021 agaaaaagcg gaaaaaggcg agctgctgtt tggaacgatt gatacgtggc tcatttggaa 928081 aatgtcaggc ggaaaagcgc atgtgaccga ttactccaat gcctcaagaa cactgatgtt 928141 taatatttac gatttaaaat gggacgatga actgctcgac attctaggcg taccgaaatc 928201 catgctccct gaagtgaagc cgtcctctca tgtgtatgcg gagactgttg attatcactt 928261 cttcggaaaa aatatcccga ttgctggagc ggcaggcgac cagcagtccg cattgttcgg 928321 ccaggcatgc tttgaagaag gcatggggaa aaacacttac ggcacaggat gtttcatgct 928381 gatgaatacc ggggaaaaag caattaagtc cgaacatggg cttttgacaa caatcgcttg 928441 gggcattgac ggaaaagtga actatgcgtt agaagggagc atttttgtcg caggctctgc 928501 catccagtgg cttagagacg gtttgagaat gttccaggat tcatcgctaa gcgaatctta 928561 tgcagaaaaa gtggattcaa ctgacggcgt gtatgttgtt ccagcatttg tcggactggg 928621 aacgccttac tgggacagcg atgtgcgcgg ttcggttttc ggcctgacaa gagggacaac 928681 aaaagagcac tttatccgtg cgacactgga gtcattggct tatcagacca aagatgtgct 928741 tgacgcaatg gaagcagatt caaacatttc attaaagacg ctccgtgtag acggaggagc 928801 tgtaaaaaac aatttcctaa tgcagttcca aggagacctg ttgaatgttc ctgtggagcg 928861 cccggaaatt aatgaaacga ctgcacttgg cgcggcttat ttggcgggta tcgctgtggg 928921 attctggaag gaccgttctg aaatcgcgaa ccagtggaat ctggataaac ggtttgagcc 928981 tgaattggaa gaagaaaaac gaaatgagct gtataaaggc tggcaaaaag ccgtgaaagc 929041 agctatggct tttaaataaa gtaatactat ggtataatgg ttacaagtta ataagaacgg 929101 tcctgagatg aggagagacc acagcaccaa agtgtaagca tgcactttgg ctgttgtggt 929161 ctctttttct atttaccgtg acaacaagga ggaaacgtaa tgatgaatca tcaattttca 929221 agtcttgaaa gagatcgcat gctgacagac atgacgaaaa aaacatatga cctatttatt 929281 atcggaggag gaattacagg agccggaaca gctcttgacg cggcatcaag gggaatgaag 929341 gtcgcactaa gcgaaatgca ggactttgcg gcgggaacat caagccgatc aacgaagctg 929401 gtacatggcg gcttgcgcta tttaaaacaa tttgaagtga aaatggtcgc tgaggtagga 929461 aaagagcggg cgattgtgta tgaaaacggc ccgcatgtca ctacaccgga atggatgctg 929521 cttccgtttc ataaaggcgg cacattcggt tcatttacaa catctattgg gttaagggtt 929581 tatgacttcc ttgcaggtgt gaaaaagtca gaacgaagaa gcatgctttc agcaaaagaa 929641 acgctgcaaa aagagccttt ggtgaaaaaa gacggcttaa aaggcggcgg gtactatgtg 929701 gaataccgca ctgacgatgc gagactgacc atcgaagtca tgaaggaagc ggttaaattc 929761 ggggcagagc ctgtgaatta ctccaaagtg aaggagcttc tttacgaaaa aggcaaagcc 929821 gtcggcgtat taattgaaga tgtgctgaca aagaaagaat ataaagtgta tgcgaaaaaa 929881 attgtcaatg ctacaggccc ttgggtcgat cagctcagag aaaaagacca ttcgaaaaac 929941 ggaaagcatt tgcagcatac aaaaggcatt caccttgtat ttgaccagtc tgtctttccg 930001 ctgaaacagg ctgtatattt cgatacacct gatggccgga tggtatttgc gattcctcgt 930061 gaaggcaaaa catacgtggg aacaacagac actgtttaca aagaggcgct ggagcatccg 930121 cggatgacaa cggaggatcg tgattatgtc atcaaatcaa tcaattacat gttcccggaa 930181 ctgaatatca ctgcgaatga catcgaatcc agctgggcgg ggctgcgtcc gctgattcat 930241 gaagaaggca aagatccttc tgaaatttca cggaaagacg agatttggac atctgactca 930301 ggcctgatca ccattgccgg cggaaaactg actggataca gaaaaatggc ggagcacatc 930361 gttgatcttg tccgtgatcg cttaaaagaa gagggcgaaa aggattttgg accatgtaaa 930421 acgaaaaaca tgccaatctc tggcgggcac gtcggcggtt cgaaaaatct tatgtccttc 930481 gttaccgcga aaacaaaaga aggaattgca gccggtttat cagaaaaaga cgcaaaacag 930541 cttgcgatca gatacggctc taacgtagat cgcgtctttg accgggtaga agcgctgaaa 930601 gatgaggccg cgaaacgcaa cattccggtt catattcttg ctgaggcaga atacagtata 930661 gaagaagaga tgactgcaac ccctgctgac ttctttgtcc gcagaacggg acgtttattt 930721 tttgatatca attgggtaag aacatataaa gatgccgtta ttgattttat gagcgagcga 930781 ttccaatggg atgagcaggc gaaaaacaaa catacagaaa acctcaacaa gcttttacac 930841 gatgcggtcg taccgcttga gcaataaatc ataacgggct gtctgcagcc cgttatttct 930901 ttttacgtgc cgaaaggggg agatctcagg ttatcaagtg acagaggcac ccgcttcata 930961 taaaataatg gcataagctg atacatagga ggacgaatat gacttggaga aagagctatg 931021 aacgctggaa acagacagaa catttagatc tggaattaaa agagcgcctt attgaattag 931081 agggagatga acaggccctt gaggactgtt tctataaaga ccttgaattc ggtaccggcg 931141 gaatgcgcgg ggaaatcggc gccgggacaa atcggatgaa tatttacact gtgcgcaaag 931201 catcggccgg gtttgcggca tacatctcga agcaaggtga ggaagcgaaa aaacggggcg 931261 ttgtcattgc ttatgattcc cgccataagt ctccggagtt cgcgatggaa gcggcaaaaa 931321 cacttgcgac acaaggcatc caaacatacg tgtttgatga gcttcgcccg acgccagagc 931381 tgtcattcgc tgttagacag ctgaacgctt atggtggaat tgtggtaacg gcaagccata 931441 acccgcctga atataacggc tacaaagtat acggggatga tggcggccag ctgcctccaa 931501 aggaagcgga catcgtcatt gagcaggtaa acgcgattga aaatgagctg acgatcacag 931561 tggacgaaga aaataagtta aaagaaaaag gcttaatcaa aatcatcggt gaagatattg 931621 ataaagttta tacagaaaaa ctgacgtcca tttctgtaca tcctgaatta tcggaagaag 931681 tagatgtaaa ggttgttttc acaccgctgc atggaactgc aaataaaccg gtcagacgcg 931741 gtcttgaagc actcggctac aaaaatgtaa cggttgtcaa agaacaggaa ctgccggatt 931801 caaacttctc cactgttaca tcgccgaacc cggaagagca tgcggcattc gaatatgcca 931861 ttaagcttgg ggaggagcag aatgcagata ttctcatcgc gacagatcct gatgctgacc 931921 gcctcggcat cgcggtgaaa aacgatcaag gcaaatatac agtgctgaca ggaaaccaaa 931981 ccggagcgtt gctgcttcat tacctgcttt ctgaaaagaa aaaacaaggc atcctgcctg 932041 ataacggtgt tgttctcaaa acgatcgtca caagcgaaat cggccgtgct gtagcttctt 932101 cattcggcct tgatacgatt gatacgctga caggctttaa gtttatcggt gaaaagatta 932161 aggaatacga agcatcaggc cagtatacct tccaattcgg ttatgaagag agctacggtt 932221 atttaatcgg ggattttgcc cgcgataagg acgccattca ggctgcgctt ttggcagttg 932281 aagtttgcgc gttctataaa aaacagggaa tgtcattgta tgaggcgctc atcaatctct 932341 ttaacgaata tggtttttat cgtgaagggc tgaaatccct gacgctgaaa ggcaaacaag 932401 gagcagagca aattgaagcg attcttgctt ccttcagaca aaatccgccg cagaaaatgg 932461 cgggcaaaca ggttgtcaca gcagaagatt acgctgtaag caaacggacg cttctgactg 932521 aaagcaaaga agaagccatc gacttgccaa aatcaaatgt attgaaatac ttcctggaag 932581 acgggtcttg gttctgtctc cgtccttctg gaactgagcc gaaggttaaa ttttatttcg 932641 ccgtaaaagg gtcatctttg gaagacagtg aaaagcgact tgccgtcctt tctgaagatg 932701 taatgaagac ggtggatgaa attgttgagt caacagcaaa ataattcaag tatgagctgg 932761 gtcattgtaa atgatccggc tttttctttt tctcatccaa aagtctgaaa gaaaatcatc 932821 ctacaagtga agcaatgaaa tacaaaaaac tggtataatc ttaaatacaa gatcaatgcc 932881 ggagtgagaa acgtgagcaa aacgaggatg gaaaaattaa aaacgctgaa aacgattgcg 932941 gaaaccttaa atcaagggca cgatatcaaa gcaacactgg atgaggtttt aaaagagttg 933001 ctgagtctga caaaccttca atccggatgg atttttctga tcgaagaaga tgggtcttat 933061 acgttagcgg ccgacgctta tctgcccccg gctttaagcc gcaaggaaaa agtgctgatg 933121 tgcgaagggg agtgttactg cctgacgaaa ttcaataacg gagggcttag aaaagctgca 933181 aatatcatga actgcaaacg catcgaatca gcagaaaacc tgcattgttt tgacacagaa 933241 gggattacgc atcatgcaac tgtgccttta gaagacgggg acagaagatt cggattgtta 933301 aatgtagcgg cggccggaaa aaccatgttt gatgaggaag agctgcattt actcgagtct 933361 gtcgcctttc agatcggaac ggcaatccag cgtatgaggc tttctgaata tcaacaaaaa 933421 aatgctcttt taatggagcg taaccgcctc gctcaggagc ttcacgattc agtcaatcaa 933481 atgctgtttt ccgtcagttt aactgccaaa gctgcgaaga cactaacaaa agatgaaaat 933541 ttacagcaga tgattgattt catccaaaac ctatcacagg acgcgctcgc agaaatgaaa 933601 gcgttaattt ggcagcttcg ccccggagga ttggaaaaag ggctggctga agccattaaa 933661 agctatggtg cgctcattgg attgaagatc atttttacac aaaaaggctg tcctgttctg 933721 actgatgagc aggagcatat gctatggcgt gtcgtacagg aagctttaaa taactgcaaa 933781 aagcatgccg gaacggatac ggcgtatgtt agtctgactg cttctttgtg ccatgcggag 933841 ctggatatca tcgatcatgg ggcaggattt cgctatgaag cgcatgccgg tctgccttca 933901 cttggcataa aaggtatgaa agagcgagcg gaaaaagccg gagctaagtt ttggattgag 933961 tcagcgcttg gaactggaac aaagctgtcc atcaggcttc cgctaaaaag ccgaaaagga 934021 ggggcggtat gaaaattgtc attgctgatg atcatcatgt tgtcagaaag ggtctgcgtt 934081 ttttctttgc cacccaggat gatattgaag tcgtcggaga agctgcaact ggattagaag 934141 ccctccgtgt catcgaagag acaaagccgg atcttgtgct aatggatttg tctatgcccg 934201 agatggacgg cattcaagcc attaaaaaag caatacagca atttccggat acgaatatca 934261 ttgtgctgac gagctactct gatcaggagc acgtcatccc cgcgcttcag gcaggcgcga 934321 aggcgtatca attaaaggat acggagcccg aggaattggt gaaaacacga caagtgcatg 934381 gtggcgaata caagctttct acagctatta tgccccatgt gctgacacat atgaaaaatc 934441 agcacgaccc ggaaaaagaa aaatactatc aattaactag aagggaaaaa gacgttctga 934501 ctgaaatagc gaacgggaaa agcaataaag aaatcgcagc agccttgttt atttcagaaa 934561 aaacagtaaa aacccatgta tcgaatcttt tagcaaaact tgaagtggcc gatcgcacgc 934621 aagcagcgct tttcgcagtg aaatataacc tgaatggaga gatctcaaaa tgaacatgtt 934681 agtcataaat ggcacgccaa gaaaacatgg cagaacaaga attgcagcat cctatattgc 934741 agctctgtat cacacggatt tgattgatct aagcgagttt gtattgcccg tttttaacgg 934801 tgaagcggaa caatctgaac tgttgaaagt acaggagctt aagcaacgcg ttacgaaagc 934861 ggatgcgatt gtattattat cgcctgaata tcacagcggc atgagcggcg ctttaaaaaa 934921 tgccttggat tttctaagca gcgaacaatt caaatataag cccgttgcat tattggcagt 934981 agcgggaggc ggaaaaggcg gcatcaatgc gctgaacaat atgagaactg tgatgcgggg 935041 tgtctacgcc aatgtcattc cgaagcagct ggtgcttgat ccggtgcata ttgatgttga 935101 aaatgctaca gtggctgaaa acattaagga aagcataaaa gagcttgtcg aagaactcag 935161 catgttcgca aaagcaggaa atcccggcgt ctaaacgccg ggatttgttt atgtgagaag 935221 ggctatttga tcttcataag tcagctctgt ggcatgatca atatatcgga gaagggaata 935281 cagcatcttt tctaaaacgg cgtaatcctg ttcaaaatga tacgcatgca gaaaatgctc 935341 aattcgtttt gataacaaat cgtcctctgt acgcaccatt aaaattaata aattatccca 935401 ttgagaacga tgggtgtaat aaagcgcttt atcgtaatcg gcataatcca tgaatcgctt 935461 ctcctttctt gggtgagaag ttcatgatta gtttatgccg catcctctgt tattgacggg 935521 gcaaaacttg ccgtctgcgt cagtaaaggg gtagcaatat gagggagaca taaaatcaaa 935581 atgcctgaat gaagatatcg cttttggtaa acctatgagg gaatatattc tgggtacagg 935641 agactgaaaa aatgaaatcc ctgccgtata ccatcgcact tcttttttgc ggattgatta 935701 tcgtgtcaat ggctgcaaaa ggtcattcaa cggacacaga cgagtccgtt caaaagtggg 935761 aacagcttgc ctggagcaaa attcaggatg aatataaggg cgcttcattt tctgattatg 935821 cttatatggg gcgtacagag gtgaatgatc agcagactaa agatgtcttt cgggtgacag 935881 tcagacagaa agatgacact ttttctgttc gggccgaagt ctattttcat ccggtgacaa 935941 atcatatgat cagcatcaac gtctttaggc tctaataaaa aactgtacag ccgttaaggc 936001 cgcacagttt ctgtttttag aaatatcgtt ttgcaccgag atagcgctgt ttccagtaag 936061 agttgttcat attggaaatg acaactccgg aatcgttggc atttatgaat tccccgttgc 936121 ctaggtaaat tccgacgtgg gaagggccgg ctttatatgt tgaaaagaaa acgaaatctc 936181 cgacagcagg ctggctaact gatttcattg tgttccaata tcccgctgcc gttaatctag 936241 atacggatgt gactttgttc agtacatagt aaatgaatcc gctgcagtca aacccggacg 936301 gtgtcgtgcc tccccagcga tacggaaccc caagctgcgc tttagcggcc gaaatcattg 936361 tgttaatctt cgcactcgtt gagctggtgg tgtttgaaga accggatgaa gacgatgatg 936421 aagcttttcc ggaaatgacc agcttttggc caacctgcaa gacatccgtt tttaaattgt 936481 ttttctcacg aatctgctga gctgttacat taaatttttg agcaatcacc cataaggaat 936541 caccgctttt caccgtgtat gtagtcgtcg tgccggagct tgcatttgac gaagaagacg 936601 acgatgatga agagcctgaa gatgctttac ctgtcagctt caatacttgt ccaacgtaaa 936661 gcacatctga tttcagattg ttgatatttc ggatttgctg tacagtcagg ttatagttgt 936721 ttgcgatttt ccaaagtgaa tcaccgcttt taacggtata tttagttgtt gctgaagttt 936781 ggttcgattt ggatgaattg tctttagaag acgtatcaga gccgcttgat tttgttttca 936841 acacctgatt cacgtaaatg gtgtctgatt ttaagttgtt caagaccttc aattcagcga 936901 tggacatatt gactttgttt gcaattttcc aaagtgaatc tccaagctgc accttatatg 936961 ttcccgtaga agatgaagaa cttgaactct tattagaact gctttttgaa ctggagcttg 937021 aactcttatt agagttgctt tttttactgg aactagagct tgaagaaaca gtaccggaca 937081 cctttaattt ctgcccagca cgaattaaat cgctgcttag tccgtttaat tttttcagtt 937141 cctgcaccgt cattttaaac tcatttgcga tcagccaaag tgaatctccg cttttcactg 937201 tgtaaacaga acttccgctc ttcttggttg ttgagcttga agtagatgaa gaagtgctgg 937261 atttgctgcc tggaatagta agcgtctggc cgatcgacag aacagtagtc gaaagatgat 937321 tggcggatgt gagggccgcc acacttgtgt tataggtttg ggccagtttc cataaagaat 937381 ctccgctttt gaccttaatc gttgctgctt cagctggtgt cactactaaa gttgtgccga 937441 caatcgcaga tgctgtcagc cctgctgcta atttcttttt catcttagct ctcctttttc 937501 ccccaatgat tttgcatttg ctgtttcttt tttatatcgg cacatttgtc tcatcgtttt 937561 gcctttttat aaaaatagcc aaattatctt aacaataagg gggaaaaagg gcataaaaaa 937621 agaaggaatc ttaatctatt ccttcatttt taaaagcttc atgatatctt ctttgttttt 937681 gacgaggtcg cgcagtgtgt atttgtctaa aactgcgagg taggctaaaa gcgcttcatt 937741 cagcacatgt tttaagccgc aaaccgggga aataacacag agattcttgt tcgcatcaaa 937801 acattcaaca atattaaaat cgtcctccgt ttttctgaca acctcaccga tgttgatgtc 937861 ttcagggtcc atgcctaatc gtatgccgcc gccccgtccg cgtatcgttt ctacgtagcc 937921 gagctggccg agcctgtata tgactttcat gagatgattt tttgaaatag aatacgtttc 937981 ggcaatctgt tttatatttg aaagttctcc gggacgctct gcagccagaa aaatcaacac 938041 tcttaatgaa taatctgtat aattggttaa cttcataata agacctcaga ataagacatt 938101 ttctatatct tatcataatc gattgaaaaa tgaaaaaaaa ggaattaaaa aacatgcacc 938161 cagctgggtg catgtttttt gcttacatgt cattcggcgg attttggttt ttacggtttt 938221 tttcgatttc tgtgttttgc attttgcgtt caaatgtaga cagataacgt gatgcaaaat 938281 ccttaccgcc aaggccgaag gataaaccaa aagcaagtgc gaagccgcta agaacgatga 938341 tgaacgcgga attgacgatt gtcgcagcga cacccagctg atccagggcc ataaagaaag 938401 caagtgcgat aatcgtatat ttagcaatag gcgctaaaga cttgaattcc tgacctttta 938461 tcatgcttgc gagcactttt ctcaccaatt ctcctgcgta aaggccgagt ccgagaatga 938521 atactgcgac aaggacattc ggcagatacg cgatgatgcc ggtggcaatt tctacgagga 938581 agtgcagccg aacaatttga agcgcctcag ctgtaaagag cagaatgaca atgatttgcg 938641 caatcatacc gacaacttga gacaaggaca gctttgcagg cgttccggct tccatgccca 938701 ttttccctaa gacagaatca aagcctgcgc gatggagcag tccggacacc atggatttca 938761 cccattttcc tgcccagata cccgctaata caagcacgat ggcaatcatg atgttcggaa 938821 gcatgtttaa aatcgtattc agcatagaga cagctggttt tgaaatgccg gcgacatcca 938881 gctgatcaag cgctgaaatg accaccggaa tcataatgag cacataagcg attgttccga 938941 tgactgctga aaggcttgtg tcttttaagt aaattgataa acccatacgt gccgcgaatc 939001 tttcggtgcc gatgcttgca aggaaattcg taatgatatc acggacaagg cgggcaacaa 939061 gccatccgat taatacgata agcgccgctg caaataattt cggcagaaaa gcgagcacgc 939121 tttccatcat atttgtaaaa ggacctgaaa tgccgctgat tttcaaagaa gataagaccc 939181 ctggcagaaa aacaagcagc acgagataaa agacaatttg tgaagcggta ttgacagcct 939241 ggtgaatatc ttttccttca gacaccaaat tccacttgcg cagtttgtca ctcgtgttca 939301 gcttcatccc gatttttttg acaaggaagc tcaaaacaga agctgcagcc catcctaaca 939361 gcagaatgag tccggctttc agcacgcttg ggatcgcagc tgcaatcgcc gaaagcatac 939421 tgacaaacgg cgatgccact gttgtcaggt gcaaaatgtt aaagaataaa ataaagacga 939481 tgatcagtgc gataaaataa acgaccttgc ttatgacttt ttccgaggaa tagcgtgaag 939541 gctttttccc agcaaagagc ttgtcgtcga tttttgtttt gctgagtcct ttgtataccg 939601 ctttttcaat gattttagca atagcccagc cgattaataa gacgagtaaa gcaatgatta 939661 cgtttggcag cttactgaga taagaagaaa acacgtctgc tacattcaat tggtatcgct 939721 cctttttcgt agtatggtgt gtgtttaccc acttatccaa taagcaaaca gatgaatgtg 939781 ccgggggaat tttttcttgc ccgagtgaga ctatcatctt ttgtctggcg ggctcataca 939841 ttatagataa gtccaagtag gggggattcg gttgaacgcg gaggagaaga agggattaca 939901 gcgggcaatt gaggaaatta ccgaaattgc aaaaggattc ggccttgatt tctacccgat 939961 gagatatgaa atctgcccgg ctgaaattat ttatacattt ggcgcgtacg ggatgccgac 940021 aagattcagc cactggagct tcggcaagca gtttcacaag atgaagctgc actatgatct 940081 agggttaagt aagatctatg agctggtcat taactcagat ccatgctacg cttttttgct 940141 ggacagcaac tcactgatcc aaaataaatt gattgtcgca cacgttcttg ctcattgcga 940201 tttcttcaaa aacaactgcc gtttccaaaa cacgaagcgc gatatggtgg aaagcatggc 940261 ggcaacagct gaacggataa aacactatga acaggttcac gggataaaag aagtcgaatc 940321 ttttttagat gcaatccttt cgattcagga gcatatcgat ccgtcgttgg tccgaccaaa 940381 gctccaatgg agtgtggatg atgaggaaga ggagattgaa gaggcagcca cgccttacga 940441 tgatctatgg tctttagatg aaaagaaacc gaaaaaacaa gtgaaaaaat cgaaaaaacc 940501 gttcccgccg cggcctgaaa aagatatcct gctttttatc gaggagcatt cccgggagct 940561 ggagccatgg cagcgtgata tattaacgat gatgagagag gaaatgcttt atttctggcc 940621 tcagctggaa accaagatta tgaatgaggg ctgggcttcc tattggcacc agagaattat 940681 acgtgagctt gatttaacct ctgatgaagc gatcgagttc gccaagctga atgcaggtgt 940741 cgttcagccg tccaaaacag gcattaatcc ttattattta gggctgaaaa tatttgaaga 940801 cattgaaaag aggtacaaca acccgacgga ggaaatgaag aaaatgggcg tgcagcctga 940861 ctccggccgg gagaaaatgt ttgaggtcag ggagattgaa tccgatatct ctttcatccg 940921 caattattta accaaagaat tagtcatgcg cgaggatctt tatttgtttc aaaaacaggg 940981 ccgagattat aaaatcatcg ataaacagtg gaagtcggtg cgcgaccagc tcgtaagcat 941041 gcgggtaaat ggcggttttc catatttgac agtaaacgac ggcgattata tgaaaaataa 941101 cgaactctat attaagcatt ggtatgaggg catagagttg gatttgaaat atttggagaa 941161 agtgcttcct tatttattcc agctttgggg aagaagcgtg cacattgagt ctgtgcttga 941221 ggataaggaa gtcatgtttt cgtacgacgg aaaaggtgtt caccgcagat atttataaaa 941281 aagaggatgc agcgttctgc atccttttta ttttccagtt tttaaaatct taaatatgat 941341 gtttgcctgg tccgtattgt taatcaatcc gcggaatttt tcttttccgg ggccgtacgc 941401 gtataccggt acttcttcgc cggtatgatc ggtactcgtc catccgctgt tggagcgggt 941461 attaaaaatc ttgatgatgg ctttggaggc ccctttgctt ttgtcagcct gtgcagctgc 941521 ttcaacgctt ttgatttctt cagatgtgac tttcagattg gcatagcggg cgagcacatc 941581 tttaaccggc ttgccttcac tgattttttt ggccatgaat tcaggtgttt tcttagcgga 941641 gagaatcggt tctgcgtgcc aattcttttc cccgtttgcg ccaatggtaa agccgccggt 941701 tgtatggtca gcagttgcaa tcacaagtgt atgtttgtct tttttcgcaa attcaatcgc 941761 ggctttatag gcctgttcaa aatctttaac ctcgctcatg gctcctactg tatcattgtc 941821 atgggccgcc cagtcaatct ggctcccttc gaccatcaag aaaaatcctt ttttattttg 941881 gttcaggcga tcaattgctg aaaccgtcat gtctttgaga gacggtgttt tactgtcacg 941941 gtcgagcgct ttagcaagcc ctccatctgc gaaaagcccg agcacctgct gatctttatt 942001 ttttttcaat gcttgtttag ttgtcacata gctgtagccg gcttgtttga attcctttgt 942061 caagtttctg tccttgcggt taaaataaga ttttccgccg ccgagcagca cgtctatttt 942121 atgtttgcct tttatcttgt catccatata gctgttggcg atttggtcca tgtttttccg 942181 tgattcattg tgggcgccat atgcggctgg agtggcgtgg ttaatttcag acgtggcgac 942241 aagccctgtt gacttgcctt gctgtttggc ctcttcaagt acagatttca ctttttttcc 942301 gtttttatcg acgccaattg cattgttata tgtcttaacg cctgtcgcta atgctgttcc 942361 ggctgctgct gaatctgtaa tattatagtc agggtcatcc ggatgcgtca tcatcatgcc 942421 tgtcaggttc cggtcaaatt ctgttaactt cgggttattc ggtgtgtcac cgttattttt 942481 catggaacgg taggctctta tgtaaggcgt ccccatgccg tcgcctatca tcacaatgac 942541 atttctgatc tcagctttgt cttgtttttt ggcgctggcc ttttctgttt gctgaagctc 942601 agctccggca aagattccag ctgtaaggac agaaacagcg gcgattggca gaagttttga 942661 tttcatattt tgaaacaaac tcattttttt catgcctcct ttaatgtatt ccgtttatca 942721 tgttagggaa actttgttaa atgcggctgt tgatcatgta aacaataagt aaagccttgt 942781 aaggaaatga aaaaacgctt ttcgttatct tgccttattt gatgtaaagc attcattttt 942841 cagaaaaatc tttacctctc tgtctttgca tgatatgttt gtttaaataa aaaaactgcg 942901 gataaccaca gctctcctcg aatatacttt atcactcatt tttccgatat atgagccgac 942961 cccgaaagtt tttcatttat ttcctttatg ttgaaaaaca tcccataaaa catgacaaaa 943021 gcactcgttt tttgtcacct ttgcaatgaa aatgaaatat ttaataccct taaaaacttt 943081 tttttagaac gaataattaa gaaatttgtc acatgaagtc aagactattt ctgatgggaa 943141 tctatcctta taatagaaat caataagatt aatttaaaaa aagagataca tatatataga 943201 gttaacattt ggggaggaaa atatgaaaaa gcaaatcatt acagctacga cagcagttgt 943261 tttaggatcg acgttatttg caggagcggc atctgcacaa agcattaagg tgaaaaaagg 943321 cgacacgtta tgggatcttt caagaaaata cgacacaacg atcagtaaaa ttaaatcaga 943381 gaaccacctt cgttcagaca ttatttatgt gggacaaact ttatcgatta acggcaaatc 943441 tacaagttca aaaagcagca gttcttcttc ctcttcttct acatacaaag taaagagcgg 943501 ggacagcctt tggaaaattt caaaaaaata cggcatgaca atcaatgaac tgaagaagct 943561 gaatggctta aaatcagatt tgcttcgtgt tggacaagtc ctgaaactga aaggttcaac 943621 tagttcaagc agctccagct catcaaaagt gtcatcgtct tcaacttcta cttataaagt 943681 gaagagcgga gacagccttt ctaaaattgc gagcaaatac ggcactacgg ttagcaaatt 943741 aaaaagctta aacggcttaa aatcagatgt aatctatgtc aaccaagtat tgaaggtgaa 943801 aggaacaagc acaagcagct caaaacctgc ttcatcttca tcgtcttcaa gcagcaaaac 943861 gtcatctaca tcacttaatg tgagcaagct ggtttctgat gcaaaagcgt tagtcggaac 943921 gccatataaa tggggcggaa cgacaacttc aggctttgac tgcagcggat tcatttggta 943981 cgtactgaat aaacaaacaa gtgtgggcag aacaagcact gcaggatact ggagttctat 944041 gaagagcatt gccagcccgt ctgttggtga tttcgtcttc ttcacaacat ataaatccgg 944101 cccttctcac atggggattt acattggaaa caacagtttc attcatgcag gatctgacgg 944161 cgtacaaatc agcagcctga acaacagcta ctggaagcct cgttacctcg gtgcgaaaag 944221 attctaattt ttagagaaaa cccgttcatt ggaacgggtt tttttcatta gacggagcac 944281 aggcgttttg gttgctccta aaaatgaaaa tgtgataaaa aatccaagaa ctttttttct 944341 ttcttatttt cataaagggc aatcgcgtaa gcgccggcat agggcagctg tacagactga 944401 taaggaattc tgatcatctg tttctctgct aactcacgct ttactgtaga taaaggcaga 944461 aatgaaactc cgagtccttc cttgataaac cgtttcgtta tatgtgtttg agtgaccttc 944521 attgttctca caaatggaaa tgtcattctg acttgacgga gcaagtcgtc ccagtaatca 944581 ggatgattgt gggtcaaaag caggtattgt tcgagcacct ctttggcatc aatttcgttg 944641 tcttctatga aacgcttatc gggcggggca acaaggacga cagggtcttt gtataagcag 944701 tggcagctta aagaagaaga ctgtaccttt aaacagctta gtccgatatc tgcttccccg 944761 gctttaatca gtgacgcgat ttccgctgat tcgaaaatcg taaccgccat ttctgtttcc 944821 gtattcattg ctgtgtaccg cttcatgaca gaaggaagca ctgtatctgc aataagcgga 944881 gaaaccgcga gctgtaaggt ttgagagtag ccttgtctca ctctgtgaag ctctgccatg 944941 ctgttttcat aatcatcaag aagcctgagc gcatacggca aatacgccct gccttcatca 945001 gtcagctgga tttgcctgcc tttacgctcg aacagcttgc agctgatttc tttttctaat 945061 tgcttgatat gtacggtcac agtaggctga gataagaaaa gcgtttccgc cgtttttcgg 945121 aagttctcat attttgcagc ggtcacaaag gtgtgaagcc atttgaaatc catttctatt 945181 ctccctctga ttaatatttt taattaattc cctttaaaat attgattatt ttttaaatat 945241 tatatttact ataataacag aaaaggatag ggggaataca aatggtacat tacggattaa 945301 agggaattac atgtgtagaa acatccatca gccatattga tggtgaaaaa gggcgtctga 945361 tttacagagg acatcatgca aaagacatcg cactgaatca cagctttgaa gaagcggctt 945421 atttgatttt atttggaaaa ctgccttcaa ctgaagaatt gcaggtattt aaagataagc 945481 tggctgcgga acggaatctt ccggaacata ttgagcgctt gattcaatca ctgccaaaca 945541 acatggacga tatgtcggtg ctgagaacgg ttgtttcagc attgggggaa aatacgtaca 945601 cattccatcc gaaaacagag gaagcaatcc ggctgattgc aatcacgcct tctatcattg 945661 catacagaaa aagatggacg cgcggtgaac aagcaattgc accttcttcc cagtacggac 945721 atgtcgaaaa ctactattat atgctcacag gtgaacagcc ttcagaggca aaaaagaaag 945781 cgcttgaaac ctatatgatt ctggccacgg agcacggcat gaacgcatcg actttttcgg 945841 cacgagtcac gttatctaca gagagtgatt tagtgtcagc cgtcacggct gctctcggta 945901 cgatgaaagg tccgctgcac ggaggtgctc cttctgcggt gacaaaaatg cttgaagaca 945961 ttggagaaaa ggaacatgct gaagcatatc tgaaagaaaa actcgaaaaa ggagagcgct 946021 tgatgggatt cggccacagg gtgtacaaaa caaaagaccc gcgggcagaa gctttgagac 946081 agaaagcaga agaggtggcc ggcaatgacc gtgatcttga tcttgcgctg catgtagaag 946141 cagaagcgat tcgtttgcta gaaatctaca aaccgggacg aaagctgtac acaaatgttg 946201 aattttacgc agctgcagtg atgagggcca tcgattttga cgatgaattg tttactccga 946261 ccttttcagc aagccgaatg gtagggtggt gcgcccatgt actggaacag gcagaaaaca 946321 acatgatttt ccgcccgtca gcgcaatata ccggtgccat tcccgaggaa gttctttcat 946381 aacatatttt ggcgtttatt catttctgtc gtgtggtaac gttcagtatc aaccacatgt 946441 ctaggagtga tgaatgtgaa cccaatggac agacaaacag aaggacaaga accgcagcat 946501 caggacagac agccgggcat tgagtcaaaa atgaatccgc tgccgctgtc agaggacgag 946561 gattatcgag gaagcggaaa actgaaagga aaagttgcga tcattactgg aggcgacagc 946621 ggaataggga gagcagcagc tattgccttt gctaaagagg gggctgatat ctccattcta 946681 tacttagacg agcattcgga cgcagaggaa acacgcaaac ggatcgaaaa ggagaatgtc 946741 cgctgcctgc ttatcccggg agatgttggg gacgagaacc attgtgaaca agctgtgcag 946801 caaacagtgg accattttgg taaactcgat atcttagtga acaacgccgc tgaacagcat 946861 ccccaggaca gcattctcaa tatttcaaca gaacagctgg aaaaaacctt tcgcacaaat 946921 attttttcca tgtttcatat gacgaagaaa gctttgcctc acctgcaaga ggggtgtgcc 946981 attattaata cgacatcgat taccgcttat gaaggggata cggcgttaat tgattattcc 947041 agcacaaagg gtgcgattgt ttcctttacg cgttccatgg cgaagtcgct tgcagataaa 947101 ggcatcagag tgaatgcggt ggcgcccggt ccgatttgga caccgcttat tccggcgaca 947161 ttccctgagg aaaaagtgaa acagcacggc ttggataccc caatgggaag accgggacag 947221 ccggttgagc atgcaggcgc ctatgttctg ctggcgtctg acgaatcttc ctatatgaca 947281 gggcagacca ttcatgtgaa tggcggccgt tttatttcaa cgtaatcaac gaaaaaccag 947341 ctcaagagct ggttttttgt gtggtgaaaa atttcaaaat aaaaaatttg tcgatttttc 947401 taacaatttt gttttcattt ttgcaatttt atatataata ttgagtagga gaaaggaatg 947461 attcgcgacc agtacaaata tagtagaaaa aaaagaataa tgaccattgt tactcatgaa 947521 ttcagaaaat tcaaataaaa tatataaaaa tagatgatcg ggagttgaag gggaatgaaa 947581 gggagcgttt ttaggaagaa aagcattcag gatttaatcg ctgcgacgag cggggaaaag 947641 tctttaaaaa gagaattagg ggcatttgat ttaacgttgc ttggaatcgg cgccattatt 947701 ggcacaggga tttttgttct gacgggaaca ggcgcagtca cggccggtcc cgggctgacg 947761 atttcatttg ttgtggcggc gttggcttgt ttattcgccg ccctgtctta cgcggaattt 947821 gcgtcaagtg tgcctgtttc aggttcggtg tatacattca cttatgcgac attgggagag 947881 cttatggcct ttattatcgg gtgggattta attttagaat acatgctggc ggtaagtgca 947941 gtgtcggtcg gctggtctgg ttatttccaa tcgtttttat cagggcttgg cattcatctt 948001 ccggttgctt taacagcggc accgggcgca gtgaaaggca cctttaccct gtttaatctt 948061 cctgcattcg tcattgtaat ggcgatcaca tatttgcttt atttaggcat caaagaatca 948121 aaaagagtca acaatatcat ggttatcttg aagatactgg ttgttctgct gtttatcgcg 948181 gtggcagccg tttacgtgaa gccgcacaac tggcagccgt ttatgccaat gggctttggc 948241 ggcgtgttca gtgcagcggc gctcgtattc tttgctttta tcggatttga cgctgtatcc 948301 tctgctgcgg aagaaacgaa aaatcccgcg aaggatctgc ctaaaggcat tattttctct 948361 ttactggtct gcacgatttt atatgtcacc gtatcagcca tcatgactgg ggttatcccg 948421 tttgctcaat ttgcgggtgt ggatcatccg gtttctcttg ttcttcaaag cgcagggcaa 948481 aattgggtgg caggcatcat tgatattggc gccgtgttgg gaatgacaac agttatgctc 948541 gtgatgcttt acgggcagac ccgcgtcatg tttgccatgt cgcgtgacgg acttgtgccg 948601 ggttcacttt ctaaagtgca tccaaagcac aaaacacctt atgtagccac ttggtttttc 948661 ggaacgatgt cggcgcttct cggctcactt gttccgctgg atgaacttgc aaagctggtg 948721 aacatcggga cgttgtcggc atttgtcctg atttctgtgg cagttatcgt tttgagaaag 948781 aaacagcctg atcttccgag agcttttaaa tgcccgggag ttcccgtgat cccaggcctg 948841 gcgattctgt tctgcctgtt cttgatttta aatctgggat gggtgacgat tgtccgcttc 948901 ctagtgtggc tgttaatcgg cttggtaatc tatttcctgt attcaagaaa gcattcaaaa 948961 ttaaatcaat aaccttttga taaagagagc ggccatacag gccgcctctt ttctgttctt 949021 ggcaaatgaa tctatagaaa tgaagacaaa aataagagat aatataggct ggaaaggaag 949081 tgacgtttat tgtctgagca aaaaccagtc caatgggctt cgaaaattgg tttcgtcatg 949141 gcagcggccg gctcggctat cggcttgggc gcgatttgga agttccctta cgtagcgggg 949201 accaatgggg gaggagcctt ttttcttatc ttcgtgttat ttaccatcct cttaggctat 949261 ccgcttttgg tgggggaatt tatttttgga agacggaacc agacgaatgc cattgatgca 949321 tataaaaaag aagcgccgcg atcagcttgg tttcttacgg ggtggatcgg cgtagcggcg 949381 tgtttcttag tgctgtcgtt ttacagtgta atcgggggat ggattttgct gtatatcgtg 949441 aaaacagcgt caggatcact gtccgggctt tctcaagcac agtatggcgc tctttttgct 949501 tctattatcc aaaatccggt gcagacgctc gcggctcagc ttgtctttat ggcactgact 949561 gtactcgttg tcgcaagagg ggttcaaaaa gggattgaac gggtaagcgc ggtgatgatg 949621 ccgattttgt ttttattgtt tattctgctc gttcttcggt ctcttacgct taatggtgca 949681 atggaaggcg taaagtttct gcttgtgcct catttcggcg atctgactcc ggaatccata 949741 ttattcgcgc tgggacaggc cttctttacg ttaacactgg gggtttcggt gatggtgacc 949801 tacagctcct atttgccgaa aacacaaaat atccctcgtt cggcagcctc cattgtcttg 949861 atgaatatca ttgtgacact cttggcaggt ttggctattt ttccggcggt tttctcattc 949921 ggttttcagc caaatgaagg accgacattg ctgtttacag tgcttccggc cgtttttgaa 949981 cagcttccgt tcggcacatt gttttttatc ggctttctcg ttgcattttt atttgcagcc 950041 ttaacctcag cattttcgat ggttgaaatt atcgttgcca caatcggaaa aggggacgaa 950101 aagaagagaa aaaaactgtc atggacgagc gggcttttga tctttttggt cggaatccca 950161 tgctgcttgt cttatggcgt tttgagtgat gtgcacctat ttggcaaaac gttttttgat 950221 attgccgatt ttaccgtcag caatgttttg atgccttcag gcgctctgtt aatttctcta 950281 tttatcccgc tgaaaatttc gaaaagcgaa ctcttggctg aaatgcgaaa tggatcaaat 950341 gcaggtaaag cattctttta cacatggttt tatttgcttc gttttatcgt gccgcttgcc 950401 attattatcg tgttcttaaa tttaatcgga attttatcat tttaaaaaac aggctccgtt 950461 tccggggcct gttttttatt taataagatg atatcaacgg tgcccatgcc gttttcagtt 950521 tttggatgcc gagcctgatg tcctcttctg acaaaccgcc ataaccgatt aagacagaag 950581 taaaaggcgt ctgttctata tatgagggag acacgggata gagggttaca ccgtggtcag 950641 cggctgcttg tattgcttct tcctcacttg ctggaaacaa aaggcgcagc agaatgtgaa 950701 gccccgagtt cttaccgaga atctcaacgg tgtttcccag ttcagagcga atggcttcta 950761 acaggacagc gtgttttttt cggtataagc ttctcattct atttatgtgt ttttgccact 950821 ctccggtttc gatgaagtct gccagtgcca attgcgagtg ggcagaaacg gtctgcttca 950881 ttaactgaac attgttttgg atcggttcca tgagttcagg gggcacaatc atgaagctga 950941 gccgcaagga aggcagaagt gactttgaaa aagtgcccag atatatgact ctgccattcg 951001 gatcaagacc ctgtaaagac ggaatgggat ggccgctgta gcgaaattct ccatcgtaat 951061 catcttctat aatgaatgaa tttgtttctg ccgcccatgc cagcagctcc tgtctgcggg 951121 taatcgtcat aatggtccca atcggaaact gatgcgaagg agtcgtatac atgagataag 951181 gattctgacg gtagagctca tccggcagga cgccttctgc atcagaacaa atcggagtga 951241 catccatgtg atttgcttca aacatccttc ttgaacggtg aaagcccggt tcttcaaagc 951301 cgatttttgt acctggcttt agcgaaaggc aaagattttg cagaagcacg gtggttcctg 951361 cgccgatgat aatctggccg ggttcacaat ttactccccg agacagcctg acgaatcggg 951421 caatcatgtg cctgagttcg tattctcctt gagggtcgcc agaggtgtga aacgatccgg 951481 aatagcgatc aagacttttt actatgcttt ttctccatgc gttaaaggga aagagggtcg 951541 gatcaacgct gccctgatgg aagtcaatag caggtgcgtt tttttgatgt aatcccggct 951601 gtacagactg ctgaaaatgg tcaggagctg tcgggaatcc tggttctact tccgccgcga 951661 accagccgat tttcggcttg cttttgacat agccctcagc agttaattgc tcataagctc 951721 gttctatagt tgccgtgctg acatcgagca agctggagag cctgcgtttt gacggaagtc 951781 ttgttccctt tgtgattcgc gcatgtgaaa tttcttgttt aaaaaaggta taaagctgtt 951841 catacagcgg tgttttgctc tttttatcaa gaaacggcgt aatatccatc tcatgtctcc 951901 tttgtagctg gcatggtcat tttttctgat attggctatt tggcaaatgc catttattag 951961 ctatgatcat tgtaacgaaa ggaaagggga ttgagaagat gatccatatg aaacaattaa 952021 cctcgaaaga agaatgggct gagtcgtatc cgattatgag tgaattgaga acagaactgg 952081 atatagagac gtatttacaa aggcttgaag cctgtgtgca gaaagaatcg tatatgctgt 952141 ttgccttata tgaaaataca gcaatcagag cgctgtgcgg ggctctgccg agagtttcca 952201 ttcataaagg agagcacttg tggattgcgg atcttgttac aacggcacct tgccgatcaa 952261 agggatacgg caaaatgctt ttggattatg cctcagactg ggcgagaaaa gccggactcg 952321 gttttgtcag tctttcatct ggccttcagc gtaaagacgc acatcgattt tatacagata 952381 aaatgggttt tactatagaa agttatttgt tccgaaaacc ggtataacga aaaaagacgc 952441 ctgaaaaggc gtctttttta aaagccaaac tgtaaattcg tatctacaga tacaatggta 952501 tacacacaaa taatcacaaa gagattaagg atgacgccga gcaggcctgg acctgtgcgc 952561 cctctcttga tgaagagttc aacaacgccg aacggaacgg cagccatggc gaacggaagc 952621 atttgatagg aataaaacgt gacgttgctg ataatggcca aattcagcaa cagcagggac 952681 agaaccgctg tcccgacaga gatccagccg aatacattgt gttctttaaa aattcttacc 952741 agttccataa ttccacctcg ccgacattcg ctgattttac agatttattt ttcagcatgc 952801 gctggatttc cttggttggc cctgtaacga ccgaaccgta tacattgaca ccgtttttct 952861 ctacataatc taatcggtta tctacattca ggtctttccg ttttgaaatg acctgagccc 952921 atttttcgtg tttggacatg aatttcaggg cgttgataaa ctgatcgcca ttcgacttgc 952981 cttttgtatt aagggcggcc aagaactttg aatcctttcc aggatagcca agaggttctg 953041 tggaagctgt cttatttgtg tttttctctg tttcgattgc gttccacaaa aagctcacat 953101 catagccttt gaatttgtta tacacgtctt ttgtcggata tgcacggtca tatgaaaggt 953161 agacctctga taccgttcct tcaggcaatg tgcttaacgt tttttctgct tttgcggtcg 953221 tttgttcaga cttgtttgaa ggatgtgtaa agtaatggcc ggttttattc acttctaagt 953281 catagtagtt tactgccggc gcttttactt tgttataaaa catttcaacc cgttcattcc 953341 ctacggcagc cgtcttcgtg ccaatctgct tttgcagcgg gaattccgta ttcattccaa 953401 atagcttcac ttggcttttc agtccggaag tatcaacaag aacattcggc atggtcaggg 953461 ctacagtgac tgcggcagtt tccataaact cattgccggt gctgtgtttt ccacccattc 953521 cgtaatagag gtagcttccc agcgtacaaa gcggcaaaat catcaatgtc gaaatgacgg 953581 caagcacaga aattcgcaaa taagacttgc gtttgccgta ggctaaaatc gctttttgtt 953641 tttcaggact gatgctgaga tcccaatcgt tatcgtcctc tagttcgctg tcaatcagtt 953701 cctgatatac ttcaagcttc tcgagttctt cctcaaatgc agtcatttcc tggtcgctca 953761 tttccccatt tttatattga tcaaaacgct ttttaaattc ttcattcatc attaacacct 953821 ctattataaa gtgctttcag ccgctgtctg gcacgaaata aaacactttt aaaattcgcc 953881 tctgaaatat tcataatatg ggatgcttct ttgtagttta actcttttaa ataatatagc 953941 gttaaggcct cccgataatt atcggggagc tcggacatat aaccagtcag cacttccttt 954001 atctctacct gatgggcagg actttgaaca gcattttgaa agaggcttcc gattaagtca 954061 tcagaaatgg ttacttcttt cttatgcttt ctgacgtaat caatgaaggc gtttcgcgcc 954121 acttgaaaaa gccagggctt tactttgctg tgatcatagg agtgaatgtg tatgtatgcc 954181 cgcataaagg tttcctgcag taagtcttca gcaagatgct tgtcttttgt catggagagc 954241 aggaacctgt aaacatcatt catgtacatt tggtaaattt catcgatcgt cactgccttt 954301 tctcccctct atgttataca cgcataagaa aggtttaaag ttgcacatta catgcaaacg 954361 gcttttttat acctaatcaa acaccattac tatatagtac ccaaaaatgg ccgcaaaaga 954421 tagtgcggag aaaggtttaa cattttttcc agaggggaaa agatagtgaa aaagtgaagg 954481 agtggcacaa tggaatatac cagtatagca gatacaggaa tagaagcctc cagaatcggc 954541 ctcggcacat gggccattgg cggaacgatg tggggaggca ctgacgaaaa aacatcgatt 954601 gaaacaatcc gcgccgctct tgatcagggg attacactga ttgacaccgc accggcttac 954661 ggcttcgggc agtccgagga aattgtcgga aaggcaatca aagagtacgg caaaagagac 954721 caggtgattc tcgcaacgaa aacggctctg gactggaaga acaaccagct gttccgccat 954781 gcgaacagag cgagaattgt agaggaagtt gagaattctt tgaagcggct tcaaacagac 954841 tatattgatc tttatcaggt gcattggccc gatccgcttg tgccaattga agaaacggct 954901 gaagtcatga aggaattata tgatgcggga aaaatccggg cgattggcgt cagcaatttt 954961 tcaattgagc aaatggatac atttcgcgcc gtcgcacctc tccatacgat tcagcctcca 955021 tataatctgt ttgaaagaga gatggaagag agtgtccttc cttatgcgaa agataacaag 955081 ataacaacat tattatacgg cagtttatgc agagggctgt taacaggcaa aatgactgaa 955141 gaatatacat ttgagggcga tgatctgcgt aatcacgatc caaaattcca gaagccccgc 955201 tttaaagagt atctttctgc tgtgaatcaa ttggataagc tggcgaagac acgttatgga 955261 aaatcagtga ttcacttggc tgtcagatgg atcttagatc agccgggagc ggatatcgct 955321 ctttggggag caagaaagcc tgggcagctt gaggccctat ctgagattac aggctggacg 955381 ctgaacagtg aagatcagaa agatatcaat actatattgg aaaatacgat atcagaccct 955441 gtcggaccgg agtttatggc cccgccgacc agagaggaaa tataacaaaa gctgagggcg 955501 aatcctcagc tttttggcgt ttaaacgaga gaaatcttaa aaattagtac caggtaataa 955561 aaaatattgt tataatagat gacagaaaga atcattgatt acgacaaagg aagtgcgata 955621 tgtataagtt ttgtgcaaat gctttaaaag ttattctttc tcttcgcgga ggagtgaagg 955681 tgtataacaa agaaaacctt ccggccgatt caggttttgt catcgcgtgt acacattccg 955741 gctgggttga tgtgattaca ctcggagtcg ggattcttcc ttatcaaata cactacatgg 955801 cgaaaaaaga gctttttcaa aataaatgga tcggttcgtt tctgaagaaa attcatgcct 955861 ttccggtaga tcgggaaaat cccgggccaa gcagtattaa aacgccgatt aagctgctga 955921 aagaaggaga gatcgtcggt atcttcccaa gcggaacaag aacctctgag gatgtgcctt 955981 tgaaaagagg tgcggtgacg attgcgcaaa tggggaaagc gccgcttgtc cccgctgcat 956041 atcagggccc ttcaagcgga aaagaattat tcaaaaaagg aaaaatgaag ctgattatcg 956101 gtgagcctct tcaccaggct gattttgccc acctgccttc aaaggaaaga cttgcagcaa 956161 tgacagaggc tttgaatcag cggattaaag aactagagaa taaacttgat cagctataag 956221 gcgttctgag agattgtcct gaaactgtga aaataagaaa agcaccctat acaaggtgct 956281 tttcttatta tgcttcctgc tggttagctg tctccagaag ttcttcttct tgaagctttt 956341 tcacttcaat atatgcgacg tggtggccgt caatttcatt aatgatgaat tcgcagccct 956401 cttcgatgat ggaatcatct ttttcaacat cgtatttttg agtaaggaac cagccgccga 956461 ttgtatcgac ttcttcgttc tctaaatgga tgcctagcag gtcgtttact tggtcaatta 956521 acacttttcc gtcaagaata taatggcctt cgccgatttt gcggatttcg ctaatttcat 956581 caatatcaaa ttcgtcgcgg atttcaccga caatttcctc aatgatgtcc tcaaccgtca 956641 caagcccggc agtaccgccg tattcatcag acaaaatggc catgtggacc ctctcttttt 956701 gcattttgac aagcaggtct tggatcggcg cagattcaat gacatgaatg atagggttga 956761 cgaattgaga aatggtggaa tcaacagata cctcaccgct gatgcaggcg gtcagcactt 956821 ctttaatgtt aataaccccg ataatgttat ctttatcgcc ctcttccaca gggtagcggg 956881 tatatttttc aatctgaatg atgtccatca tttcagaaat cttgatatca tgcggaaggc 956941 tgacaatttc ggtccgcgga atcataattt ctttcgcgag cctgtcgtca aattcaaaga 957001 ttttattcac atatttaaac tctgattggt tgatttcacc gcttttatag ctttcagaca 957061 aaatgattcg cagctcttct tctgagtgag ccagttcgtt ttctgaaacg gtctccaggc 957121 caaatgcttt ggtcaataac cgtgcggaat tgttcaaaag ccaaatgaat gggaacgcga 957181 tgcggtaaaa ccaaatcagc ggtttcgcaa acagcataga cactgcttcc gccttttgga 957241 tagcgactgt tttaggtgca agttctccga caacaacgtg taagaacgtg ataatggcat 957301 acgcaaaaat aaacgatatg acatgtgaaa gggaacctgg aacgttcatt tggacgaaaa 957361 gcgggtgaag cagcctttcg atcgttgatt cacctaaaac ccctaatccg atggaagtca 957421 atgtaattcc gagctgacac gcagataaat attcatcaag atgcgtggtc acttttttta 957481 cggctattgc tgctttattt ccttccgcga tcagctgatc gatccgtgag cctctgattc 957541 tgataatggc aaactcagat gccacgaaaa atgccgtcag ggcgattaaa acagcaacta 957601 aaatcaaatt cactatgtcc aattagaacc ttcactctag caatgagaat gaaggtaaca 957661 cctcctgtta gataaaatgg ttttaactta acagcagcat aaatgattgg aacacggcga 957721 gcttttcagg cgggagtttg cttttcagct tgtcacgatc ctcgggcttc agccgttcaa 957781 accgatgcaa gattccggag atgttttgat tcatatgatc aatttctaat gccagatttc 957841 caatttcatc atcaagttta gctgaagagg gaaactggtt ctccagtcga tctttaatat 957901 cggacagggc caatcgctgc ttcttgcaat ctacaataaa tataagtcgt ttgagtgcat 957961 tttcgtcgta gtaacggtaa tttgaacagg atctggccgg cgtaagcaga ccgagattcg 958021 tataataatc aactgtccgt ttcgttactc cggcgagtgc cgctagttca ctgatgcgat 958081 aagtctcagc cccatctata tccctcccaa ccatcacgtt atagttatga gaatagttta 958141 atatatgaac ggtgtcttgc acaagtttat tgtttttttt agaccggaat tggaagttgt 958201 ggaattcatc atctgattga agtaacatag gaagatagaa ttttcaaatt tttatatgcg 958261 gaagggacag atgaaattgg ctgggttatc ccgggaagtt gaagaaaact taaataaagg 958321 atcatggatt cgcaagctgt ttgatgaagg tgcaaggctg aagaaggagt tcggggaaga 958381 ccaggtattt gatttttcac tcggcaaccc gattgttgaa ccgcctgaag cttttaagag 958441 agcgttaata gaggaagctg aaaaaggcag ccacggatac atacaaaacc aagggcttct 958501 tgcagcgaga gaaaaagtcg cgcaatttct gggctcgcgt tttgaagctg atttctcagc 958561 ggagcgcatc gtcatgacgg tgggcgcggg aggcgctttg aatgttgcgt taaaaagcat 958621 cgtaaaccct ggggaagagg tcattattct tgcaccttat tttgccgaat ataagttgta 958681 tattgagaac tacgggggaa aagccgtcag ctgcccgttg acaagccggt ttgagatcga 958741 cattgaagcg gtaaggcaat cgatcactcc acagacgaaa gggctgattc tcaatacacc 958801 gcataacccc acaggcactg ttctcagcca gaaaaatata gacgatttag gcgctttatt 958861 aaaagaaata gaagagaaga gcggccagac gatttatgtg ctgtttgatg aaccgtacag 958921 tcaattaatc tatgatgaag agctggcaaa tccgtttcaa tcgtaccatc gtgtgatatt 958981 ggccagctca ttcagtaaag atctcggcat agccggagag cggctcgggt atatcggatt 959041 ggacagccga atgccggatg cggacctttt gatcaacgct tttgtgtatt gtaatcgaac 959101 gcttggattt gtgaatgccc ctgtcatgat gcagcgggct gtggcacgaa tggatgattt 959161 aagagtagac gcgagcgctt ataaagagcg ccgggattta atggtagaca ttttaaaaga 959221 agccggtttt gaatttgaaa tgccaaaggg aggtttcttt gtttttccga aatcgccgat 959281 tgaagatgaa gttgcatttt gcgtgcatgc cgcccaaaaa tacaaattat taattgtgcc 959341 gagcagcggt tttggaatga gcgggcattt ccgattatcc ttcagtgtgc cgatcgagca 959401 gattaaaaac tcacgggaca ttttcatttc tttatataaa gattttgctt aagaaggcaa 959461 agaaaagaaa acagttttca aggctgtttt ctttttatat ccgcaaaatc cttcctcttc 959521 caatccagac aggcgcagaa ttgacaagca ggcatgcagt taaggctttc ttcatgataa 959581 aagtctaaaa attaaaaatc atttttggaa tgagttgtgt tacaataaaa tatacaattt 959641 ataatcaaac tttgactttt ggaggtggta tgatggggcc ctctgcttag gcaacaatac 959701 accgcgtacc tcaatgttaa ggaaaaatga ttatatcagg aggtgactcc ttatcctttg 959761 ttgagaggat agggttaaat ggacgatatt gacagtctga ttttaattgg cgtgctcatt 959821 gctttaaccg cgtttttcgt tgcaagcgag tttgcgattg ttagagtgag gagatccaga 959881 atagatcagc ttatcacaga aggaaacaaa cgggcgatac tcgcaaggcg tgtcattaca 959941 gatttggatg aatatttatc cgcatcccag ctaggcatta cattgacatc aatcgggctt 960001 ggcgtactgg gtgagccggc ctttgaacgg ctgctgcatc cactgtttga accgctcggc 960061 ttgccggact cggtttcaca tgcagtctct tttgcagtcg cgtacggctt gatcacgttc 960121 ctgcacgttg ttgtaggtga actggccccg aaaacggtcg cgattcaaaa ggcagaacag 960181 ctgactttac tgatagcggg ccctttgcgt ttattctatt tgctcctgtt tccgtttatt 960241 tggatcctca atggatcggc gcggctttta tgcgggatgt tcggtttgaa gcctgcgtca 960301 gaacatgatg gttcccattc tgaggaagaa ctcaggatgc tgttatctga gagtttaaaa 960361 aacggagaga ttaatccgtc tgaatataaa tatgtgaata agatttttga atttgataat 960421 cggatcgcca aagaaattat gataccgcgg aaggaaatgg ctgctgtgtc aactgagatg 960481 acgatggccg agatgcttga agtcatgctg aaggaaaaat acacgcgctg gccagtcaca 960541 gatggagaca aagacagtgt gctcggtttg gtcaatacga agcatttgtt ttctgatttg 960601 ctgtttatga cagaagaaga acgaatgaag atgacgatcc atccgtatgt gaggccggtc 960661 atcgaagtga ttgaaacgat cccggttcat gacttgctga ttaaaatgca gcgcgagcgc 960721 attcatatgg ctatattgtc ggatgaatac ggaggaacct cgggacttgt gacgacagag 960781 gatattcttg aggaaattgt cggagagatc cgagatgaat ttgatgaaga tgaacagccg 960841 ctgatccaaa agcttggcga cggccattat gtgatggatg gaaaggttcg gatcgatcag 960901 gtgaacagcc ttcttggcgc atcgattcaa gaagacgtcg atacgatcgg cgggctgata 960961 ttaaaagaaa acatcgatat tgaggctggt gaatccattc gcatcggttc atatacgata 961021 aaggtgctga agatggacgg ccgattaatc aagcaaatcg atataaaaga agaagccggc 961081 aacacaaccg ggattacggc gcaccacaag ctgccgctgc ccgagcctgt gatgctgaac 961141 agtgcaacct tgagcgagaa ataagctcaa ggttttttta tattgtgatt gtccagccgc 961201 accaaaatgc aaaaagcgac ccgcaaagtg tcaggacgat gtacaagatg ctttctttta 961261 cacgtttggc cataaggagt tgaatagttt caacgctgaa tgtggaaaag gtcgtaaagg 961321 cgccaaaaaa ccccgtgcca atgataagcg agaccgaagc atttgcaacg tgaagtcctg 961381 taaatattcc gagcccgaga gctccgagaa tattgactgt cagtatgcca atgggcaggc 961441 tgagaccttt ggttttggcg gttatgacat tgccaagcca gaagcgaagc attgcgccaa 961501 gtccgccccc tatgaaaata cccgctagtg tcatttttcc tgcagcccct ttctttgctg 961561 aatgcctgct atgcgccgtc ccacaaaaac accaatcagt gcaaatatga tccctgatat 961621 caatgaggct gccacatata aaagagccaa tgagggttgt ccttgcaaaa gcatcactgt 961681 ttccttagaa aacgtggaca ttgttgtgaa gcctccgcaa aagccggtgc ctaaaaaagc 961741 cgacagcaga ggccgttttg ccccgatcat aaaaaatccg gtcaaaatgc ctaatagaag 961801 gctgcctgcc gcattttcca gccaggttgc cgccgggaac tgaccggtgt gtatccataa 961861 gtttaatccg tatcggaggc aggcgccaag cgcgcctccg ataaaaaccg cgctatatat 961921 tttcatgttt gccatccttt atgatgaaat ccgggtaatc tgtaacgatg ccgtccacgc 961981 ccatggcttg taattttgcc gctgtctttt gattgttgac agtccatgca aatatgttta 962041 agccattttt attgatggag ccgatcatca gacggttaag ccgtgtgtgt tttatattga 962101 catagtttgc aaaagagcgg aaggccttca tctgatttct ggacagcatg ccaaagttgg 962161 gccttgtaat gaccgctgtc ggaatcgaag gataaagctc gcggaacctt tggacggagc 962221 ggaactgaaa ggattgaaca atattattga tagaaaaaga aaattgccct aatagctgtc 962281 ccacctcttc ttcaattccg acttgagacg gatggccttt tagttcaatt aaaaggccga 962341 tttttttgtg gtagcgcttg agcaccgctt ccagggttgg aatacgctct ccttgaaaag 962401 cgggaccgta ccagcttcct gcatcgagtt tttgcaattc ctccaaggta aaatccttaa 962461 caaagcccga tccgtttgtt gttcggtcaa ccctgtcatc gtgtatcaca acaatctgcc 962521 tgtcttttgt aagctggaca tccagttcga tcatatctgc attcattttc accgcaaggt 962581 caaatgcggc aatcgtattt tccggagcgt agccggatgc tccgcgatgg gcaatgatgt 962641 acaagctaag tcagctcctc gtatgggcat ttctgttatt gtatcaaatc catatatgca 962701 ccgcgataca aactggtgaa ttttttctgc catatcggaa tggtccgggc tgaggaatgc 962761 gtataactaa aaaaagacac tcagcgtatc agaacacatt tcgtcagaaa attaggtctt 962821 tcgacatgtt cacaacaaaa tatgatcctt tataatagca aaaaaggagg cgagatcatg 962881 ggaaaaggga gaatcagagt ggaggaaaga attaaagccg aaacggatgc tgaaatgcaa 962941 aaagcaactc tccttgatca gacacaaacg aaaaaaggta agtgactgtc cctattgaat 963001 ctggctgata gatgaattga gaaatgaccc cggcgtttcg ccggggtttt gtgctgcata 963061 agacatttaa atgaacatcc ttacgaatat tttagtataa taaacaattg attgggatag 963121 aggggagaca gtcatgccgg attatctgca gcagtatttt acgcttgata acatcataca 963181 aatcggcatc agcttggcga ttttgctggt gtttcttata cttagaaaat tattcacaag 963241 atattttttt aacctgcttt ttaatttgac aaaccggccg aaaacagaaa tttttaaaca 963301 ggtggttctg gcgtttgata agccggccag atggtttttt gttgcccttg ggctgttttt 963361 agcgatccgg tattcaccgt ttttagatga gcaaatgccg gtcatcagca aaatataccg 963421 ctcactgatt gtggcgctct tgtgttgggg tctttgtaat ttgaccgcaa catcgtcgtt 963481 tatcttccat aaggtgaacc agcgcttcga gcttgacatg gatgacattc tggccccgtt 963541 tttatccaaa ttgctccgtt ttgtgatcat tgcgctcagt gtcagtgtga tcgctcagga 963601 attcaattat gatgtcaacg gatttgtagc gggccttggt cttggcggac tggcttttgc 963661 gcttgccgcg aaggatacca tcagcaactt cttcggcggt attatcatta ttactgaaaa 963721 gccgtttaca attggtgact gggtggagac gtcgacagta acaggatcag tcgaggatat 963781 tacctttagg agcacgagat tcagaacagc acagggggcg cttgtaacgg tgccgaactc 963841 tacgctgtcg atggaagcga tcacgaactg gacaagaatg accaaacgcc agattacgtt 963901 ttccatccat gtgtcctacg ctacgccgat tgagaacctt gaacgctcca ttcattctct 963961 cagaacaatg ctcttagagc atgagggcgt tgataatgaa ataatcatgg tcaactttga 964021 tacgtttgcc gacagctact acaatttatt ttttaacttc tatacaaaaa cgacggtttg 964081 ggctgaaaac cttaatatta gagaggatat caactataaa attattgaga ttttaggtgc 964141 agaaggcgtt cagtttgcat atcccggcca aatggttgtt gtcaagcaaa agcacgaaag 964201 cgaccaattc caggtgaatc taaataaaga ggaaaaggaa cgggcttaaa agagagactt 964261 cgtctgacag aggcggagtc tttttcatgg taaaataaga gaaaaaggcg gtgttgagtt 964321 ggaaacattc aaaagtattc tacatgaagc acagagaatt gttgtgctga ccggagcggg 964381 aatgagcaca gaatcaggga tccccgactt tcgttcagca gggggcattt ggacggagga 964441 tgcctcaaga atggaagcga tgagccttga ttatttttta agttatccgc gtctgttttg 964501 gcccaaattc aaagaattgt tccagatgaa aatgagcggc agctttgaac cgaatgaagg 964561 ccatttgctt ttagctgagc tggagaagca agggaagcag gtcgatattt tcacgcaaaa 964621 cattgacggt cttcataaaa aagcggggag caggcatgtg tacgaactgc atggttctat 964681 ccagacagca gcttgtccgg catgcggcgc ccgatatgat cttccccatt tgctggagcg 964741 ggaggtgccg gagtgcacgg cggccggaaa caatggggac atttgcggaa cggtattaaa 964801 aaccgatgtt gttctctttg gcgatgccgt catgcacttt gacacccttt atgaaaagct 964861 ggatcaagca gatcttttat tggttatcgg cacgtctctc gaagtggctc cggctagatt 964921 tgtgcctgag gatgcaagcc tgattcccgg catgaagaaa gtcatcataa accttgaacc 964981 aacgtattgc gacagcttgt ttgacatggt catccatcaa aaaatcggcg agtttgcccg 965041 aagtttgggc atgaaaaagt gagccgcttt atgcgcctca cttttttatt catgaacagg 965101 aaccattgtg tcctctaaca ctccgaagga atagcctttt tcttttaatt tattgattag 965161 taccggcagc gcatttacag tagcaggaag atcatgcatg agaattacat ttgggcggct 965221 tgaagagctg tgttccatat tctcaagctg ctgtaatacg gcggtcacat actgtgaatt 965281 ccggtatttc cagtccatgc tgtcgatcgt ccaatcccag tacacaaacc catctttctc 965341 cagattgcga atttgtgagg cggttagtga cggcttgctt ccgtatggcg ttctgacaag 965401 atcggtttta tatcctgtaa tgtcctgcag cgtgtcacgc gcctcctgca tttcttttag 965461 cggagatgtc ggtgtttgat agaacaatct gttattgtgg gtaacgccat gtaaaccgag 965521 tgcgtggcct tccttttctg ctcttttcac agcctgcttg aattcgttca tccgcggtga 965581 cagcataaaa aacgtcgctt ttacatcagc gcttttcagt acgtcgagca agcgggttgt 965641 aacggctgaa gggccgtcgt cgaaggttaa gtaaaccgtt ttatctccca tgttctgctt 965701 tgtctgcaga tgttttatca ggagatcggg ggagtcgttt ttcagcttaa ggctttcctt 965761 ctcatctcga agctggccgt ttgttgtgac agtgacttcc tttgctttcg ttgaactgtt 965821 ggaataaccc aaaatcacca taagcaaaag cagcacacat aaaactgcta aacttgcaaa 965881 tttaaaagca agcgaaactg cagaaggaga agcctctcct ctcgtttgtc gcataacaat 965941 ctctccattg gcataaaatc tctacataat gctgtacagc aggcagctta tgaagatgcc 966001 ttatgtttac aacctatgta ttaccagtca agtatacagg aataaaactg gaaagcacat 966061 agaaaatttg tcgaaatgtc agattttaag gaaaaaataa actcctttcc gctatagatc 966121 tcttgatctt tctgtttttc agcttgtcca atatggtaga attagtgata atgacagctt 966181 gaatgacatc agggacatct cgaaaaggga gggcttttat gaaggtttta gtcaatggcc 966241 ggctgattgg gcgcagtgaa gcatcaatcg atttggaaga tcgcggttat cagtttggtg 966301 acggcatcta tgaagtgatc agggtgtaca aaggagtatt gttcggctta cgtgagcatg 966361 cagagcgttt tttcagaagt gctgctgaaa tcggaatttc actgccattc agtatagaag 966421 atctcgagtg ggacctgcaa aagcttgtac aggaaaatgc ggtcagtgag ggagcggtat 966481 acattcagac aacaagaggt gtggccccgc gaaaacacca gtatgaagcc ggcctcgagc 966541 cgcagactac tgcctatacg tttacggtga aaaaaccgga gcaagagcag gcatacggag 966601 tggcggccat tacagatgag gatcttcgct ggttaagatg tgatatcaaa agtctgaatt 966661 tactgtataa tgtcatgacg aagcaaaggg cctatgaagc cggagcattt gaagccattt 966721 tacttaggga cggcgttgtt acggagggta catcctctaa cgtttatgcc gttatcaacg 966781 gcacagtgcg aacacatccg gctaatcggc tcattctcaa tggaattaca cggatgaata 966841 ttttaggact gattgagaag aatgggatca aactggatga gactcctgtc agtgaagaag 966901 agttgaaaca ggcggaagag atctttattt cgtcaacgac ggcagaaatt attccggtcg 966961 tgacgctcga tggacaatcg atcggaagcg ggaaacccgg accggtgacc aaacagcttc 967021 aggctgcttt tcaagaaagc attcaacagg ctgctagcat ttcataaatg aacgaagaaa 967081 agagcccgct ttttacagcg gggctctttt tattttttaa caaatccaat caaaatggag 967141 atcattggcg atatatagag gaagaacgta aatgggatgt agtctatgac tggaacacca 967201 agtgcgctcg ccataaatgc gccgctgacg ccccaaggaa tcaatgggtt aattaatgtt 967261 ccgccgtcct ctaatgatct tgtcagaaat tttcgctgga tgtttcgttt gtcatataaa 967321 gatttaaatg attgtcccgg tattaatatc gataaatact gttcgcccgt tgccaagttg 967381 acgccgatgc ttgagcagac agttgctgca acaagacggc cttttgagcg gatgcctttc 967441 atgacgcctt ccaatagtgc agaaatcaat ccgattttct ccatcaatcc gccgagtgca 967501 aaagcaatca taatgagaga gacagagccc atcatggatt gcagtccgcc tctgttaata 967561 attttagcgg ctgcctcatt gtcagtttcg aaagttgtgc cattttgtaa agctgtcata 967621 aacgcctgca ggctgctgta gggtacaaaa atagcagtca aaattcccga ggaaataatt 967681 ccggcagtca gaacggggat tactgatacc cgtttcattg ccagcaaaac gactaagagc 967741 ggagaaagaa gggcccacgg tgtcacgttt gcagcatctt ttattccggt tatgacctgc 967801 tgaatattat cggttgaagc agcgtccgct gacactgatg aaccgagaaa gtaaaacaga 967861 acgacagtga tgagcaaagc tggaatggtt gtgcccatca tatggcgaat gtgttcaaag 967921 attggtattt cgcctattcc ggctgcaaag ttggttgtgt ccgacatcgg cgacatttta 967981 tccccaaaac aagcgccgca tatgactgcg cctgctgtcc attcaagcgg aacgccagcc 968041 gcgctcgcca cgccgatcag cgctactccg attgtgctta cagttgtcag acttgagcca 968101 acaagtgtgc tgatgatcat acatgaaaac aaagcagtca acagaaggtg gcttggttca 968161 ataaaggata gggcataaac tgtcatagtc ggtattgcgc cgctgtacat ccaggcgccg 968221 attaagatgc cgatcagcgc tagaacaata atcggctgta cgccgttttt gatcccgtct 968281 acaatccctt tttcaatgct cttccaggga aatccaaacc ataaagctgc tgctgaaagc 968341 atgacaacac ttaaaaacag cgggatatga ggttctacat gaagcaagaa taagcaagaa 968401 ataataatgc acaacatgaa tataaataaa ccgacggcta acggaaacgt cagctttttt 968461 tgagaatcca aaataacacc ccatatttat ctttaatgct tttgtgcttt tgggcacgaa 968521 agcattataa cagaaaaaaa cgaaaatcta tgttttttca caattatgaa tataaaagaa 968581 gtgagcacag ggcgtgctca ctttacaatc aggacgggta tatccgattt cgctgaaagc 968641 ttttcactta cacttccgaa tattagcttt ttcagcctgt tttggtctct gcttccggtt 968701 acgatcatat cggcagaaat gcggtttgca tgctcgataa ttgattcagc cggatcgcct 968761 tctaatatat cgatatctcc atctgcctgc tgttcattca gcatcattct ggcttcggcg 968821 atgacttctt ccgtacggtc ttcatagatc attggctcag gtgatgttac atccgatatc 968881 agcggatcag gaacacttgt catgcctccg ctgatatagc ttgcctcagc tgcgggtctg 968941 ggcgggtcga tgacggtctg attgtctttc atatcatgtg aatgggcgac ggtaatagcg 969001 gcatttacgg ttttagcaag atcaatggct gtcagaagcg ctttcttact attttcactt 969061 ccgtcaaacg caacaatgat acggtcagca tggaacatcc ttctcaccct ttcaaagcgt 969121 cttacaacac tactacccga atttgagcac aattaacctt ttcctattca agtaatgatt 969181 gacaataaaa ggttttgttt atatgatgat aaaaagatga aatcagaatg gaaggagggt 969241 ttgctatgcc aaggaatttg cgtgtttatc aaacagtttc atattggcgc ggcaaacctt 969301 ttgttctgtt ttcgtgaacg gttttttagg tcggaccgcg cgctgaaaag cgctgtgcgt 969361 aacatatcgg ttaaaaaagg catggagctg acgcttcatg ccttttttat atacaaaatc 969421 taaggaaaga caggtgtatg ggatgtgaag acaaatacag aggcgagggc agttcgtgcc 969481 aaactggatg aaaaaagctg caaggaaaaa atagaaggcg gctgatgagg agatggggat 969541 agatgttttc agttttgaaa aagcttggct ggttttttaa ggcgtactgg ctgcgctata 969601 cgattgcgat tgtcctttta ttagcagtca atgtcattga aatgtttccg cctaagctct 969661 tggggaacgc catagatgat atgaaagcag gggcatttac tgcggaaggg ctgctgtttt 969721 atatcggtat cttttttgtg ctgacggcgg ccgtgtatat catgtcttat ttttggatgc 969781 atcagctgtt tggcggagcg aatctgatgg agaaaattct tcgtacgaag ctgatggggc 969841 atttgctgac tatgtcgccg ccgttttatg aaaaaaaccg aacaggcgat ttaatggcac 969901 gagggacaaa tgatcttcag gccgtcagtt taaccacagg gtttggcatc ttgacgttag 969961 ttgattctac gatgtttatg atgacgatct ttttgacaat ggggtttttg atcagctgga 970021 agctgacctt tgccgccatt atcccgcttc cagtcatggc gattgcaatc agtctatatg 970081 gaagtaaaat tcatgagcgg tttactgagg cccaaaacgc gttcggggcg ctgaatgaca 970141 gagtgctgga atctgtttca ggcgtgcggg tgattcgcgc gtatgttcag gaaacaaacg 970201 atgttcgccg gtttaatgaa atgaccgctg atgtttatca gaaaaatatg aaagtggctt 970261 ttattgattc actgtttgag ccgacggtaa aactgcttgt cggcgcaagc tatctgattg 970321 ggctcggcta cggagcgttt cttgtattcc ggaacgagct gacgcttgga gagttagtgt 970381 cctttaacgt ttatctcggc atgatgattt ggccgatgtt tgcaatcggt gaactcatta 970441 atgtgatgca gcgcggcaat gcgtcattag atcgggtaaa tgaaactctt tcttatgaaa 970501 cggatgtgac agatccaaaa cagcccgctg atcttaaaga gcctggagat atcgttttca 970561 gtcatgtcag ctttacatat ccaagctcaa caagtgacaa tcttcaggat atttcattta 970621 cggtgcgaaa agggcagact gtcgggattg caggtaaaac cgggagcgga aaaacgacaa 970681 ttattaagca gcttttgcgc cagtatcctc caggtgaagg gagcattaca ttttcaggtg 970741 taccgattca gcaaatccct cttgaccgtc tccgcggatg gatcggatat gtgcctcagg 970801 atcatttact gttttcacgg actgtaaaag aaaatatttt atacggaaaa caggatgcaa 970861 ctgataaaga ggttcagcaa gccattgccg aagcacattt tgaaaaagat ttgcacatgc 970921 ttccgtccgg tctggagaca atggtcggtg aaaaaggcgt ggcactgtca ggcgggcaga 970981 aacaaagaat ttcgatcgcg agagcactca tggcgaatcc ggaaatcttg attctggatg 971041 attcactttc cgctgtagat gccaaaacag aggctgcaat tatcaagaac atcagagaaa 971101 accgcaaagg aaaaacgaca tttattttga cacaccgatt atccgcggta gagcacgctg 971161 acctgatcct tgtgatggac ggcggcgtca ttgctgagag aggcacgcat caagaactgc 971221 tggccaataa tgggtggtac cgggaacaat atgaaagaca gcagctgttc actgcggaag 971281 aagggggagc aggggcatga aaataggaaa aacgttatgg agatacgcac ttctttatcg 971341 aaaattgctg atcacagccg tccttttgct aactgttgcc gtcggtgcag aactgactgg 971401 gccctttatt ggcaaaaaaa tgatagacga ccatatcctc ggcattgaga aaacatggta 971461 tgaagctgcg gaaaaagata aaaatgccgt tcagtttcac ggcgtctcat atgtcagaga 971521 ggaccgattg caggagcctg tttcaaaagc aaaagaagcg catatttatc aagtgggaat 971581 ggcgttctat tttgttgatc aggctgtcag cttcgacggg aatagaacgg tttctgacgg 971641 gaagctgacg atcacaaacg gagacaagag ccgggcatat gctgccgaaa agctgactaa 971701 gcaggaactt ttccagttct atcagccgga aataaaggga atggtgttac tgatctgcct 971761 gtatgggggc ttgcttgtgt tttcggtatt ctttcaatac ggacagcatt atctgctgca 971821 gatgagcgcc aatcggatta ttcaaaagat gaggcaggac gtgttttcgc acatacagaa 971881 aatgccgatt cgctattttg acaaccttcc ggccggaaaa gtcgttgcgc ggattaccaa 971941 tgatacggag gctattaggg atttatatgt cacagtgctt tcaacatttg tgacaagcgg 972001 aatctatatg ttcgggatat tcacggcttt gtttctgctt gatgtgaagc ttgcgtttgt 972061 atgtctggca attgtgccga ttatctggct gtggtcggtc atataccgga gatatgcgtc 972121 atattacaac caaaaaatcc gctcgatcaa cagtgacatt aacgcaaaaa tgaatgagtc 972181 aattcaaggc atgaccatta ttcaggcttt ccgccatcaa aaggaaacaa tgagagaatt 972241 tgaggaatta aatgaatcac atttttattt ccaaaacagg atgctgaatt taaactcctt 972301 aatgtcccat aatctggtca atgtcatccg caatcttgcg ttcgtctgtc tgatctggca 972361 ttttggcggt gcgagcctga atgcggcggg gattgtttct atcggtgtgc tgtacgcgtt 972421 tgtcgattat ttgaaccggt tatttcagcc gatcacaggc atcgtcaatc agttttcaaa 972481 gctggagctt gcaagggtct ccgccgggcg tgtttttgaa ctgcttgaag aaaagaatac 972541 ggaagaagcg ggtgaaccgg cgaaggagcg cgcgctgggg cgggttgaat ttcgtgatgt 972601 gtcatttgcg tatcaagaag gtgaagaggt attaaagcat atttccttta ctgcgcaaaa 972661 aggcgaaacc gtagcgctcg tcggccatac cggatcagga aaaagctcga ttttgaatct 972721 tctgtttcgt ttttatgatg cgcaaaaagg tgatgtctta attgatggaa aaagcattta 972781 caacatgtca agacaggaac tcagatccca tatgggtatt gtgcttcagg acccgtactt 972841 attctcgggc acaatcggat ctaacgtaag tctggatgac gaaagaatga ctgaagaaga 972901 aataaaaaat gcactgcggc aagtcggtgc tgagcctctt cttaagaagc ttccgaaggg 972961 cattaatgag cccgtgattg aaaaaggcag cacgctatcc tctggagagc ggcagttaat 973021 ttctttcgct agagctttgg cgtttgatcc cgcgatcttg attttagatg aggcaacggc 973081 gcatattgat acagagacag aggccgtgat ccagaaggcg cttgatgtcg tcaaacaagg 973141 acgcaccacc ttcgtcatcg ctcaccggct ttcaacaatc agaaatgctg atcagatttt 973201 ggttcttgat aaaggagaaa ttgttgagag agggaaccac gaggaactga tggcattaga 973261 aggccaatat tatcaaatgt atgaactgca aaagggacag aaacattcca ttgcataacg 973321 ctcaaaaacc caaaacaatc gtgttttggg tttttggttt atgtagtcaa taagccagtc 973381 cgacacggtt tccgacatac tcacctgtaa cgagctcacg atataaaaag tccgcagtat 973441 cgccgaccga aatgcttgtg ccgccctcag gcaaaacgtt acgctccgta cgataaacgc 973501 cggttgctgt tccgtccggg aggtaagtgg ggcagatgat tgtccagtct aatgatgatt 973561 ctttaagcat ttcgtatact tttgcatgct ccttggctgc gcgggtctgc tttcgtttcg 973621 attcatttgt ttcaaaccgg tattttcccg gttcatatcg ggaatctagg atccctgcgg 973681 tgccgatcgt aataagccgt ttgatatgct gttcctccat aacggagaga atgtgtgcca 973741 tagcagttga caaggtatca tcaccatctg tgcctagaca gctgatcacg atttcagcat 973801 tctccattat ttttttcaca tcttctaagc ggcgggcgtt ccccatgaca gttctgtctt 973861 ttgaaagggg aagatcagca tgttgagatc tgatcagagc gaaaatatca aatctttcat 973921 ctgctgcagc ttgtgttaaa aaggcttgtc cgacgcggcc gctggctcct aataaagcga 973981 ttttcattaa aaaacctcct cgcctttcat tataaaagga tgttctcagt ttgaacagcg 974041 cgggaaagaa tacctgtaca aataaacaga acgatgggaa acatattcat gaatcatgga 974101 tacacttacg aattgaacca gctcccaatt cacaatggtg atgaatgaca ccccgattcc 974161 ctcccttttt ttctaggata tgtggagcag gaaaaaaggg tgacaaaata aagagagcgc 974221 ggaaaccgcg ccctctatag ccatatattg aattgttatt gaactctgcc gcccatttgc 974281 tgctgagcga aagatactaa acgttttgtg atttctcctc cgacagaacc gttagcgcga 974341 gaagttgtgt ccgctccaag gttaacgccg aattcagaag cgatttcaag tttcatttga 974401 tcgatagcct gagctgcgcc aggaactagt aagtcatttg aagagttttg gttagccatg 974461 tgtaaaatct cctttttatt tagtatggtt gggttaactg gagttgcacc aatctgtgaa 974521 cccttctcgg gtgtcactgc cgcctcggcg taacccaatg ctttgccggc ttgttactac 974581 gtattatgtt aaaatggccg gaaaatcatg cggagaattg tgtggtaaat cttgagaaat 974641 aaaaaaagct tagccgttta ggctaagcta gtcataaata tgaaaaagca tcagttcatg 974701 tatctcgttt gtaagagcag gctcgtcagc gcgggcggga aacaagtctc cccattcaat 974761 ctcaccgctc ttatgataga tgccttcata atgggtccct ttataataaa atgaaatttt 974821 ccatccgggc agcttttctt ttgggaacaa aggtttccag ctgaaatgag aaatcattac 974881 ggccacgctc cttacatttg gtatcaattg acctaaataa aaacggctta tgttcattgt 974941 atcattgttt cagaacatca ttgaagaggc ctaaatatgc agtttgtccc agctttggat 975001 aaagataagc ccgctttatt aaaaaagcgg acaggttacg aaggccacaa tgcttccgga 975061 gatgtgattg ccttctcaga taaatatgac gcgtattcaa aacttcttcg ttttgtaaga 975121 gaatcaacat gatgcaaatt tggatgagaa aaaatgcttc ggcccgggcg cgaattcgct 975181 tcaaacatcc atactttacc gttctgatca atgccaaaat cgaaaccaat ctccccgata 975241 aatccctcga tatgatcatg aaggacatgg cttgcagtca gtgccgctgc agaaagcttt 975301 ttaatgacct caactctttc agcgggatca tcgtatactt ccgcaagtgt ctttacagtg 975361 ccgccgttag aaagatgtgt tgtaatgctg ttctttccgg aaatttttac ggcgattgct 975421 gtcactgtcc attttccttt tctgttttta ttggtatgga cacggaaatc cgctggtttg 975481 ccttgaaatt cgatgagatc aacaccttgc tgaatgagaa agtcggacgg gttgtgatgt 975541 ttttgaaatt ctgcaaggaa tgaggcggca tcggaataat caattgatgt aaaagttttg 975601 gcgtcattcg tatgctttac cgtcaggccg ccatctgttc ttgtcagctg ataaatgccg 975661 gtgccgagtg ctccatttgc cggtttgata tagacttttt tgtatgcgcc acagagctca 975721 tctatcagct ccacagacgg tgtcagctcg gatctaggca aaaagggtgc cgttcttgga 975781 tctttttcga gcaattgatg aacgttccat ttattgaaaa acgttttatt aaaccatggg 975841 atctgatatt catcgatcag cctctttttt gtatgttgca agagaagtga atcttcaatt 975901 tttcggttcg gcaaacggtc ataaacgacg ttcggcaatg gaacgatttt tttctcccag 975961 ccgttttccc tgtaaaggag gccttcaatc gtgccttcct cccaattgat ttggtgcgcg 976021 ccaaaaacga agcagtagcc cccggcttgc tcgtgtaacg tgacaagttt agaaaaaaag 976081 agggaacgat ccttaaatgg gcgttcaaga gatacagtaa accctgccgt aaagatgccg 976141 actaacggcc cgatatgcac tgtatgatca tgaatcagta tatctgccct gcttcggtgg 976201 ggaagcaaaa gctcatgaaa cagattttca gagagaagca cggtttgttc cagatgccgt 976261 ctgtaagcaa cgtggcatct gacaaccttc gttccgaatg cggcatgcaa aagtccgtct 976321 tgcttcagcg aagagggcag aaacagggtg ttttcactgg ttttgtctat gccgatcaaa 976381 aaccgtttag gattcacgcg gaagaactcc tttctggctt tgctcagaaa acagatattg 976441 gcagcgtttt aggggacaag tgtacagctg ttctttttgc tcgggagaga cacgcaggat 976501 tgacttcctg cctggtttgg aattgatatc taaaatccaa attctcccgt cctttgcaag 976561 acatatatca agaccgagtt caaacaacgg cccatagcgc tcgtcaagat aatacggaac 976621 cgattgggta attgaaaaca catcatctag taaaaccact tgctgttttt tcggtatatc 976681 ttcaaaccag gagtcaaatg tcagcgcatc agatccgcct gacaaattgg ccagcagccc 976741 gtgtttgtat ccgcgtctta ctgcctttcc gactgtattc cattcacctg cttcgttttt 976801 ttccataaac agacgaatat cacaagggta ttgttcctta tcttgaatgt ttaagtaagg 976861 ctgaagcaaa tattgatgct gaagcacttt tttgcaccat gttttaaaag aagtctggtt 976921 ggaaaacgtt tttgtctgct tatcctttcc gatgtgataa gtagcagtga tgtttttctt 976981 gcccagcttc aaaagaatca cgcctctgcc tcccgcgccg aatgccggtt taaggatgca 977041 ggctttttct ttggataaaa aggagtgaat ttgttcgtag cggctcacct ttatcgtttc 977101 gggaatatag ggattgatta cagagtgctg ctgcaaatcg tgaaggacgg tccacttatc 977161 gggaagaccc cgcccgataa attccgtttt cggatatttt ttgagccact caacgattgg 977221 ttttgctttt tgggaatgtg aatccttgcc gtaaaaacag cgatcataaa tataatctgg 977281 aatcgccatt tcagtttcgt tccatgtgct gctggccgaa tgatagaccg atgctttgac 977341 acgcaaagtg tcaggtgaaa tatcaaatgg tgtaaaccgg atgaaacgta tgccgaattc 977401 gggtgctctt ttggccagtt ctgcggaata atccgcttca tgctggcggg ataaggacat 977461 aaaaccgagt gttatcatgg tgagactccc ccttttattc aaaagctgcc ggcgggtgtc 977521 cgcagcttta cactaaatac atgtaagacg aacgcagctg acggtattct actttacaga 977581 atacgattct ccaccttgcc ctattccaaa agaacaagct gattttctaa gaacaggaat 977641 ttgtctcctc gtttgctaag tgattgcatg agcctctata atacgtatag gtacataatc 977701 tatatgaaaa aagctgaagc acagatggag gaagatgaat aggaatgggt attgcaggaa 977761 cctttatttt tatgatcgtg atcggcgctg ccattggagc ggtgaccaat catttagcaa 977821 ttcaaatgct gtttaggccg tataaagcgt actatttgtt tgggaaacga gttcctttta 977881 cgcccgggct gattccaaga cggcgagatg aacttgcaaa acaaatggga ctgatggtag 977941 tcaatcatct cttaacccct gaaggcatta aaaagcggct cgtctctgat gcagccaaaa 978001 cgcaggctct tcgagtgggg gaacagctga ttcaaaagct gtcactttct gaagtgacag 978061 taaaagaagc gcttgaaaaa gccgggatga agcgccccga aaaagctgct gatgcatgga 978121 tcagcagctg gaccgatgat aagctgcatg agcttttccg ccaatacggg gaccaatcgt 978181 taaaagagct ggtgcctata gaggtgcagg aaaagcttga ggaaaaaatt ccgatgattt 978241 caggatatat attgtcacgg agtgtccgtt attttgaaag tgatgaagga aaaatccgtc 978301 ttggcaatat gattgatgac tttttaaaag agcgcggcat gcttggaagc atggtgcaat 978361 tgtttcttgg caattcaagc cttgcggatc gcgtgctgcc ggagctgctg aaattcttgc 978421 gcaatgagga aacaaataaa ttgctttctg atctcttaaa aaacgaatgg ggcaagctga 978481 gggagtatac gtttaatgaa gcagatgaaa aatggaatgc aaaggcgctc attttcagtt 978541 tgaaacgaag agtgctgcaa gcattttcga ctgccccttt cttcaacaat acgattggca 978601 cgcttaccgt ccgctatgaa tctgagctga cccagcaaat gctgccggca ctattagaca 978661 aattgcttga aggtatttcg tccaaccttg aaagtgtctt aaaacggttg cgtcttgagg 978721 aaatcgtcaa ggagcaggtg gatcagttcc cggtggagcg tcttgaagaa atggtgctgt 978781 ccatttcaaa aaaagaattt aaaatgatta cctatttggg gggccttctc ggcggaatta 978841 taggcgcgat tcaagcattg tttgtcatcc ttttttaaga agaaatggtt tttgattaat 978901 gaaaggagct ccatagtctg ttatagtgga gtggtatgtc aaacggcaat gatgaaagga 978961 gctatttaca atggctgtta atttttatga tgtagcgtat gatctggaaa atgcattacg 979021 cgggagcgaa gaattcaccc gtttaaaaaa cctttacgac gaagttaacg cagatgaatc 979081 agcgaagcgc atgttcgaaa acttccgtga tgtacagctt agactccagc aaaaacaaat 979141 ggcaggagaa gagattacac aagaagaagt gacgcaggct caaaaaacag ttgcgcttgt 979201 acagcagcac gaaaaaattt ctcagctgat ggaagcggag cagcgcatga gcatgctgat 979261 tggtgaattg aacaaaatca ttatgaagcc tttagaagag ctttacggca gtgttgaagg 979321 ctaataagca aaatcccttc ttggataaga agggattttt tattcactca gcaaacttgg 979381 aaatccaatg aatcttttac ctctccattg atgatgactg ataatgtatg aattcctttg 979441 taatgctttc tggtggttaa atccttaaag gattggattc ttgtgtatga cttcgtttcg 979501 ttttttcgta tatttgtttc tgttatttta aatactttct gatgacgctg gcctcttgct 979561 tttacaaaat caattgcgta ctcaattctt actttttgat ccctgtctga atgaatatag 979621 aaagaaaatt caaggctttc gccaataact atacgtttgg gctggcatgt taaatcatgt 979681 agttgtatcg aatcagcatt ttcataacca aaaagcgcta aggcctgttt atcacccttt 979741 tttaataagg tccgataggc gtgtttgata atccagtctg tatggggatg tgttccgtac 979801 cattgatctg cgacttttct cagtaaatga ggatgcgttt ttgatatatc attaaggttg 979861 ttggccacgc tttttcttac atataaagac tcgtcctgca tcagcttctc aaggatcggc 979921 aatacggggg aagggtccga tttcaaagcc ggtatcgatt ttccccatgg caggcggggc 979981 ctgctgcctt cgctcgcaag tcttctcacg tgttcatttt tatgctcaga ccatgcaagc 980041 aattgtgcaa tcatcttttc ttgatctaac agcaaaaaag gccttacagc aaattctgag 980101 gtcgaatatt gcgtaaagga ttccaatgcc tttattgatt cttcccaatg cgctaacccg 980161 tactgttcca cataatctgg aaataaaatt ccgctgagtc ctttaaaatg aggggctgta 980221 tcccgtaaaa ttgtgagcgc ttcaacgtat tgttttggca aagtttcgta taaagaaact 980281 gtcacgcggc gcatccgctc ttttaaagtg agttcaggcc agtcctccag ccgtaatgta 980341 tccaagaatc tgtttttgtt aaaatcagga taggatgacc ttacatgatg gatcaactga 980401 gatatcagtt cttcattata tatttctttt aaatcagcca tataaacacc gctttttcgt 980461 ttattattta tattgtatgg gaatgtacgt tctggatcaa gtgtatagtc ctaaaaatta 980521 acaactgatc ctaccacgga tatacaaaag ttggttactt tttttagtta aaaaaaccct 980581 tgtcatcgga aaggaaaact gagataataa cattgaaagc gcctacactt acctatttca 980641 aatggatacg gtcgcatatc atgccgttat atagagggga taagcaacag agagtaagtg 980701 ttcggagcgc atcattggtc aaacaagggg ttcctgatac atgatttttc gtaaatcgaa 980761 ataacgatat tagggagaat ggctgcttcg atcgtatcct atcaacaagc catacataaa 980821 gtctgctgag ccaggctttt tttgctttaa gaaaaggttg ttctaaacac agagacaggg 980881 tcatatccta tacacaagta cagtcatcaa ggagggggac atctctgtgt caaaacaatt 980941 gcttgcctta aatatagatg gagcgctgct tcggtcgaac gggaagattc atcaggcaac 981001 gaaagacgcg attgaatatg taaagaaaaa agggatttac gtcacacttg tgaccaaccg 981061 tcattttcgc tcagcacaga aaatagcgaa atcgctaaag cttgatgcca agctgatcac 981121 ccatagcggg gcatatatcg ctgagaaaat tgacgccccg ttttttgaaa aaagaatttc 981181 tgatgatcat acctttaaca ttgttcaagt gctggagagc tatcaatgca atattcggct 981241 tcttcacgaa aagtattcca tcggaaacaa gaaaaaggtg aattcgaatt tattagggaa 981301 agcactcatt catccgtctg acccgatctt ttatccagtc cagttcgttg aatcattaag 981361 cgatctcctc atggatgagc cggtgagtgc acccgtcatc gaggtgtaca cggagcacga 981421 cattcagcat gacattacag aaacgattac aaaagccttc cctgcggtgg acgtgattcg 981481 cgtaaacgat gagaaactga atatcgtccc gaagggtgtc tcgaaggaag cgggtttggc 981541 cctcgtcgct tcagagctgg gcctgagtat ggatgatgtc gtggccattg ggcatcagta 981601 tgacgatctg ccgatgatcg aacttgccgg tcttggggta gcgatgggga atgccgttcc 981661 ggaaattaag agaaaggcag attgggttac aaggtccaat gacgagcaag gtgtcgctta 981721 tatgatgaag gaatatttcc gaatgcagca gcgaaaagga tttcttgata agttccacat 981781 gaaacgtgtg taaaaaagcc gctcgcgccc tgacaggtgc ggcggctttt ttgccggatt 981841 gattttagca gtttatttct gtacactaaa gaaagttttg aatctgataa attaggtgat 981901 gaagttgcaa attaaaatag aaggcataca tgatgaccgc ctgcatcggc ctctgcaaaa 981961 tattgcaaat ttgttttatg aagagtgcga gcttgcgtat ggcggagagg agcccgcaga 982021 ttttgtcatt tctttagcgt tgtcacaaac ggatgagcat gtgacggttt ctggagaagt 982081 gaagggtact ggcataaagg aacagcatac aaaattcttt tctccagaca tgactgaaaa 982141 agaagctttt aagcaagtga aaaacacaat ttcttatgtg tatctcaatc ttcttcaggc 982201 gcatacgggc attacgcaga agtggggaat cctcacagga atccggccca caaagctgct 982261 tcataaaaaa ctgcaaagcg gaatgtccaa ggagcaagcg catgctgagt tgaaaaaaga 982321 ctatttaatt catgatgaaa aaatcatgct aatgcaggaa attgttgacc gtcagctggc 982381 ggcagtgccg gatttgtacc gagtaaagga tgaagtcagc atttatatcg gcattccgtt 982441 ctgcccgaca aaatgcgcgt attgcacatt ccctgcgtac gctatccaag gacaggcggg 982501 cagagtcggc tcattcctat ggggactgca ttacgaaatg cagaaaatcg gtgaatggct 982561 gaaggagcat gatgttaagg ttacaaccat ttactttggc ggcgggacgc cgacaagcat 982621 tacagcggag gagatggatc tgctgtatga agaaatggtc cgctccttcc cggatgtgaa 982681 aaacattcgt gagattacgg tggaggccgg tcgtcctgac acgattacag aagaaaaact 982741 cgccgtttta aacaaatatg acattgatcg gatcagcatc aatccgcaat cctacgaaaa 982801 cgaaacgcta aaggcgatcg ggcggcacca tacggttgaa gagaccattg agaaatatca 982861 tctgtcacgc cagcacggca tgaataatat taacatggac ttgattattg gtttgcctgg 982921 ggaaggcgtg aaggagttca ggcacagtct ttcagaaaca gaaaaactga tgccggaatc 982981 ccttaccgtt catactcttt catttaaacg ggcgtcagaa atgacgagaa acaagcataa 983041 gtacaaagtt gccggcaggg aagaggtttc tcaaatgatg gaagacgcgg tagcctggac 983101 gaaagagcat gggtacgtgc cttattattt ataccgccag aaaaacattc ttggaaacct 983161 tgaaaacgtc ggatactctt tgccgggaca agaaagcatc tacaacatta tgattatgga 983221 agaggtgcag acgattattg gcatcggctg cggcgctgct agtaaattta ttgatcggga 983281 tacagggaaa attacgcatt ttgcgaatcc gaaagatccg aaatcgtaca atgagcgctt 983341 cgagcactac acggacgaaa aaatcaaata tttagagcag atttttgaaa aaacgacaaa 983401 gcagcactga ttacagtgct gcttttttta tccctgtttt tttgcgggct gaacctcagg 983461 cttccattta aataccttgt tcagcaagcg gtaaattcgt tttgattcct ttgtgacaag 983521 cggtcccaaa atcgccagaa tgaggacata taatgcggca aacggcttta atgtggccga 983581 cagtccgccg gctatcccga gattcgcaac gataatcgaa aattctcccc gcgatacgat 983641 cgtcagcccg atattcgatg aagccttatg agaaagccct gcgcgtcgtc ctgccaccat 983701 tccggcgata aaatttccca gaatggtcaa aatcactgca cccaacgcaa gccaaaccgc 983761 ttcaccaagc gaaaacggat cgatgctgag gccgaagctg aaaaagaaca tcgcaccgaa 983821 gaagtcgcga aacggaacaa cgaggtgttc aatcctatcg gaatgctctg tttctgaaaa 983881 gaccaaaccg agcagcagcg cgccgattgc ttctgctaca tgaatcgtct ctgaaaaacc 983941 ggcgataaaa aagagtgctg cgaaaatgac gataataaac acttcgtttg agcgaatgtc 984001 caacagtttg ttcaacagcg gcgggagttt tcttgctgcg ataaaaaaca gcagcatata 984061 accgaaggcg atcaaaatgg acaagagtgc actccctacg gatgtcgcat cacctagtat 984121 aaggccggaa acaacggaca gatatacggc aaggaaaata tcttcaaaca tgatgatgcc 984181 gagaatcaat tcggtttccg ggttggcggt tctttttaaa tcaacgagca cttttgcgac 984241 aatcgcactt gacgagattg tgatgacgcc tgcgaggatg aggacttcca gaaaggaaaa 984301 tccggtgata aacccgtaaa gcagtccgag gctgaagtta atcaaaatat aaatcgtccc 984361 gccgaccgcg attgattttc ctgatttgat taacttcccg acagagaatt cgagtccgag 984421 atagaagagg aggaacagta cgcccattcg cccgaaaaac tcgatgattt cactgctttg 984481 aataaatgtt agatcaataa tccccatttt cggcgcgtgc ggtccaacaa gcattcccag 984541 cacaatcaga aacggaataa tcgaaaattt aattttattg gcgatcacac tggcgattgc 984601 cacaagcaca agtgcagttc cgacttcaaa tacaagatgg tccatcgggg ctcacacgcc 984661 ctctccagaa agaaaatcgt gaatcagttt cttcagatgc tttctctcac ctgagaggac 984721 aagggtgtca ttttcttcaa taatcgaatc cgctccggga tttaggagct tttcctggtt 984781 gtgtttgata atcgcaataa cagtgacatc gtaattctgg cgaacatcaa gctcaccgag 984841 tgtgcgtccg atcgatttgg cgcctttttc gaccttaaac cattcaataa taagatcgct 984901 gaaggccatt tcgatggact ccagagcttg cggtttatag accatgcccc cgagaatagc 984961 tgcaatttgc cttgcttcag aatcatccaa tgaaatattt gaaagaagct catccgggtc 985021 ccggtcatta aaccggtaaa tttcccttct tccgtcatca tgaatgataa tcgtcatttt 985081 ttcgtggctt cttgtttcga tttcaaactt tttgccgatg cccggcagat cgttttcttt 985141 aatattcaat gaaaatccct ccgaatgtag tgttggcagt atggggtgag ttacaaataa 985201 aacttgagca aattatattc ggaggtaatt agactggtat ttgacaggga cggccaaagc 985261 cttttccagc ctgtttatca gcggttcgtc aagtggtttg acagagagct gcctgacaga 985321 ctgcgccagc gggctgtact ctttgatcag ctcagccggg tgcatgctgc ccggcgatgg 985381 cgtttttgcc gattgtgttt cctgcggata tgaagacata ggcacatagc tgtcagtgct 985441 tgcttcaaac tgggaaggca gaaccacgtc cgaaggggga aagtacacca taaataaact 985501 taacagaaaa ctgatcagca atttatccat gttcctttcc tcccttctca tcaagatatc 985561 ccttcttttt cactatataa aactttatgt ttccattcaa acaatatgca tttttcagta 985621 tctattgacc ttgaaaaata aaaaggttta tttggggatg gcggggaatg tataggagaa 985681 agaaaaaagt aagcgcatac atggaggtgc ttttaatgga gtttgttcaa tatgcatgta 985741 atggggccgt tgcagagatt atcctgaatc ggcctgatgc ccatcacgcc ctgaatgaac 985801 agatgctgtc tgaattgaag gaggcagtcg aaatggcggc tgcaagcgag gcgctcatcg 985861 ttctcctgag aggaagcggg aaaggctttt cggccggcgg tgatatcagg atgatgacgt 985921 cagagcatga ccctgaccaa tttaaacggc tgatggatac gattgaggct gtcaccctga 985981 atttatatca gatgaagaaa gtgacaattg cagccattca tggtgctgct gcgggactgg 986041 gcctgagttt ggcgctttgt gcggacattg tgctcgctga aaaaaacgcc gttctcgcga 986101 tgaattttat cggcattggg cttgttccgg acggcggagg acattatttg ctgaagaaaa 986161 gaatcggtga agcaaaagcg aaaaaactga tttggagcgg aaaaaaacta tctgcctcgg 986221 aagctgccga tatggggctt cttgatggga catttgccgg agaccctgcc gaaggcgcaa 986281 gacccattat cgaaaccctg ttggcctccc ctcttttggc gatgatcgaa acgaaaggta 986341 tttttcaaag cctccaaatt gaagaactga aaaaagtgct atcccttgag cgcagcgccc 986401 aagagagaat gagaaggacc aaggatcacc aagaaggaat ccgtgccttt ttagaaaaac 986461 gggagccgaa gtttcaagcg taacagatca gccggaaagc tgatcatctg tgaaacaaaa 986521 tcagctttcc ggctgcattg actaaacgat gagtatgact atgaagctct ttttctttta 986581 agagggcttc accatgcgtt tttgccgctt cttcatgttc tgcctcgaat tgctcgttta 986641 ccagcgtgtt ccccgaagga tcaaatacgg taaggaaata atcagccatc aggtttctcc 986701 tccattttaa ggtttatcag tctttcttca tttatattct aaaaaggaaa tcaaaatcct 986761 ttattatgct ttatccaaaa ttagtatata atgggtcagg gaaggaggag attcagtgct 986821 tacaattgat cacgtaacga agacatttgg agattataaa gccgttgacg gattggactt 986881 agatattccg gaacagcaaa tgttcggtct attaggcgca aacggagcgg gaaaaacaac 986941 aacgtttcgc atgatcctag gattattaag cattacggag ggctcaatca gctggaaggg 987001 ccgtcctgtg aattatcata tcagcaacaa aatcggttat ttgccggaag agcggggcct 987061 ttatccgaaa atgaaggtaa gggatcagct cgtctatctt gccagattaa aagggatgga 987121 gaagcgagag gctgtaaaag agctcgggac atggcttgaa cgcttcaata ttacagatta 987181 cgagaataag aaggtggaag agctttcgaa ggggaatcag cagaaaatcc aattcatttc 987241 ggcagttttg cataagccgg agctcctgat tcttgatgaa ccattcagcg gcttggaccc 987301 tgtcaatgtt gagctgctaa aagaggccgt gatctcgctg aaaaacagcg gtgtttctat 987361 tttattttca agccatcgga tggaacatgt ggaggagctt tgtgagaacc tttgcatatt 987421 gcagaaagga aaaccggttg tacaaggcaa gctgaaggag atcaagcgtt ctttcggtaa 987481 aaagaatgtt accattcact ccgatgacga tctgcgcttt ttgcagtccc atgaaggcat 987541 tcttcaatgg aaggaaacgg cagacggcgt caagctgcag attgccaatg aagacatttc 987601 tcaagagatt tttgcgatgc tccaaggaaa agggtttatc agaaagtttg agcttgaaga 987661 gccgtcactg catgatattt ttatagaaaa ggtgggggcc gtctatgaat aaattttgga 987721 tcatgctttc tcatacatac aaaaataaga ttatggcaaa atcctttatt atttcgactg 987781 tcatcacggt gctgcttgtt ttagttgtaa cgaatctgga gtcgatcatt tctttgtttc 987841 aaggtgacga tgcgaaagaa aaaatcgccg ttgttgatga aacaaacgaa ttatatccgg 987901 ttttttctaa gcagctgaaa gcggtggata cagacggcga tcttgatgtg aagctgtcga 987961 agcaatcgga ggatgaggtc acaaagcaag tcaaagatga atcactcgat ggcatgctca 988021 tcatcaaacg agatgaaaaa gggaccattt caggaacata taaagcgtta acgatttctg 988081 atgaaagcac gtatcaaaca ctgcagcagg cgctgacgca aaccaaaaca gctgtcggaa 988141 cagcggagct cggcgtgtcg caggaaacga ttagcagcct ttatgcgcct gttactgtgg 988201 ggcagaaggc gctgaaagaa ggggcaaagt ctgaggaaga gcttggccag acggtagggc 988261 ttgtttacat tatgctgttc gtcatttatt tctcggtgat tatgtatgcc agcatgatag 988321 cgatggaggt cgcaaccgaa aaatcttcgc gagttatgga aatcctgatc tcaagtatgc 988381 cgccgatcca gcaaatgttt gcaaagctgc ttggtatcgg gcttgtcggg atcacacagc 988441 ttgctattat tataggagcc ggctctctgt cgcttaagct gaaccaaaag agcgaaacgg 988501 cttcatctgt cggcggattc cttaatttga ccgacgtatc tgcaaccact gtcatctatg 988561 ctgtcatttt ctttttgctc ggatactttt tgtacgcgac acttgccgcg tttctcggca 988621 gtgtcgtcag cagaatagag gacgtgcagc aaacgatcac gccgatgacg cttttggttg 988681 tcgccggttt tatgatcgcg atgttcggtt tgaatgcgcc tgacgcagga tttattacgg 988741 taacttcgtt tattccgttc tttacgccaa tgattatgtt cctgcgcgtc ggcatgcttg 988801 atattccgtt ctggcaggcg gctgtcggaa tcggaatcac actgctcacc attgtcatac 988861 tggccgttat cggcgccaga atttataaag gcggtgtatt aatttacggc aattcaagcg 988921 cgttcaaagc gatcaaacaa gcgctacgtt tagcgaaaaa ctgattggaa aacagcctgg 988981 ggattctcag gctgtttctt tattgacaga acgtgcattc gcaagaattc ggtgctaaaa 989041 taagggtact tcatcctgga aaggagcaga atgttgactg atctaacctt tattcatgcg 989101 gcagatcttc atcttgacag cccgttttac gggatatcgc atctgccgga gccgattttt 989161 gcccggatta aagaaagcac gtttgcaagc gtgagacata tgatagacgc cgcagtgaga 989221 gagcacgttg atttcatttt gcttgcggga gatctgtttg atgaagccaa tcgaagctta 989281 aaggctcagc tctttttgaa aaaacagttt gaaagactca gagagtgcgg aatttcggta 989341 tacgtcatct ttgggaatca cgatcatctt ggcggggagt ggacgccgat tgaatggcct 989401 gagaatgtcc atattttttc gtccgctgtt ccagaagaaa aatcgttttt taaagaaggc 989461 aggcgcatag caagcattta cggcttcagc tatcaagcca gagcattgat ggaaaaccaa 989521 gccgcccgct atcggagatc aactgacgca ccgtttcata tcggcatgct ccacggcacg 989581 ctgtcaggat ctgaaggaca cgatccgtat tgcccgttta cacatgacga cctcgtgaaa 989641 agcgggatgg attattgggc gcttggccat atacataaac gccaggttct atctgccgag 989701 catccggcag tcatttaccc gggaaacacg caagcacgcc atataaagga gacgggagat 989761 aaaggctatt atctcgttca tgtgacaaac ggagatatat cttatgaatt tcagagagcg 989821 catgatgtcc tgtgggaaaa agcggcggtt gatgtgacgg aggcaaagaa tatgacagcc 989881 ctcttccaaa tggtggagga cacgttttcg aagctgcgga aaaaggggag ccctgtttgt 989941 gtaaggcttg ttttacaagg gacggcgccg gaatggctgc tggaggcgcc aaaaggcacc 990001 ttggatgagt ttcttgaagc tcttcaggaa caagaagcgg aagaggaacg tttcgtttgg 990061 cctcttagat tggacgatga gacagaaaac gaagcaaacc taacaaacct tgatcctttt 990121 tttggcggtt tatttgaaga cattgatcgc agcgatctgt cagacgtgct ggaagggctt 990181 gagcggcatc cagtgtatag aaggcacgcg gaccggttta gccaagagga ggtaaaggaa 990241 ataaaagagc aggcacagat aatattgaaa agacagctta aggtgcttga tacatgaggc 990301 ggtgacagct ttgcgaatta tatctttaca tatctaccaa tacggaaaat tttccaatcg 990361 gacctttgac ttttccgcct ctcctgtcca agtcatctac ggattaaatg aggcaggaaa 990421 aacgacgatg atgtcattca ttgaaagcat gctgttcggt tttccgaaaa cgaaaaagta 990481 tgaaccgaaa acaggcggtg tctacggcgg tgttcttgaa gctgaacatc ctgagtatgg 990541 ggtgctgaag atcgaacgga cgaaagggac tgccgaaaaa ctaagcgtgt acacagaaaa 990601 gggcgaagta aagcagggag atgttttaaa gcagctgttc cagggcacag acaggtcgtt 990661 gtacaaagcc atatattcgt tcgacgtatt cgggctgcag gaaattcacg cctttaatcg 990721 ggacaagata ggggaatttt tgctcttttc cagcttgttt ggtgctgaag ccgtatcaaa 990781 gcttgattca aggctgacga aggaaagcga aaggctctat aaaccaaatg ggcgaaaccc 990841 tcaattgaat caggagctgg aaacgcttaa gcagctggca gttaagctaa aacaggctga 990901 agcagaggaa gcgggctatc atcagcttct cgaggaaaaa cgaacgcttg aagcccgcct 990961 tgcagccgcg gaaaccgaat tgaaagagac ggcgggacat atccgaatga ttgagggagc 991021 gattgagcga aagccgctgc taaatgaaaa agcgacactc gaacaggtga ttgcagaatt 991081 tccggaacac gcaggacaat ttcctgctga cggactgcat cagctggaaa aatatgaatc 991141 ccatcttcac ccgaaatcag cacagcttga ggcgcttcgg gtgaagatgg cggagttgga 991201 caaacagagg caaaagctta tccccgataa agaactattg gcgaaagaaa cgctgataca 991261 agagctttcg gcagcgtttc atatgtacca atcctgggga gaacagctgg cagccattca 991321 ggcacagctg cgccagacgt ctgcgcagac agcggcaggg ctggaacagc tcaataaaac 991381 ggatgaaaat gagctcctga atatgaacac ctcatatgat tatgaatggc agcttcagca 991441 agcggtgcag caatatgtac aggcaagaga cagaaaacgg cagcttgacg agacgtttga 991501 acttgcccgg caagagctgg aagacgcgga aaaggccgtt cgtgccgctt cgtccgcgat 991561 tcttgaaaac agccaaagaa aagataaaga agcagctctt agagcatatg atgaaacaca 991621 ggggcagcac caagagcaag cgaagctcag agaacagcta acgttttttg aaagacagca 991681 ggctaaacag aaaaagactg tcattgcagc tggtatgttg ttcatcgttc tcttttctct 991741 gctgcagcaa tggattcccg ccataagttt cggcgctgca cttattgtgt attggcttgt 991801 ttcaggaaag tcgtcttctc gaaacagccg agagacaaga cagcccatga cggatatttc 991861 accagcagaa gctgaaatgc ttagagaagc gttatgggag gatgaccgca ataagcagca 991921 ccttctcaca cagcgtgcag cgctccagca aaaagaggcg gcgtatgaaa gggtcatcca 991981 gcagtttgaa cagtgggaag ccgaaatggc gccgtccttt acacaggttg agcgttttat 992041 gaatgagctc ggatttaagg aagatccatc atttttgctt gatgcataca gcttaatgaa 992101 ggatgttaaa aaagaagtga agaaaaagca tgagctgacc atagaagcag gcaggctgaa 992161 aaagcaccgg agaacattcg aagaacgcgt cagtatgctt cttcccgtga atcagagtca 992221 ggatatctcc atttcggacg cccttcacac attgcggaaa aacattgaac gtgaaaaaga 992281 aattgagaag caaaaaaagg aaattgaaac agatattcat tatacaaagg aacagatgct 992341 tgaacttgag caagaaatac agtatttcca cgcacagatt gaacagttat ttgccgcggc 992401 tgctgcaaaa gacagagatg cgttttttgc catagccgcc atcagcaggc aattgaagga 992461 tacggagaac aagcttcatc acgtaaacgc acagcttcaa ggcgggtacc cggaggaact 992521 tgaactggcg gattccaata cgctttctga attgaaagat aagcaatttg ttgagaatga 992581 aagaaaagag cggctgactg aggagatcga gcagctccgc agccaaatcg cactgctctc 992641 agtcaaacag gaacaattag aggcttcggg aatggtctca gacctcaagc ttcaaaccga 992701 aatgcaaaaa gaacgtgtga aagaaacggc taaaaaatgg gcctccatac aaatggtcaa 992761 acaggtgatc agaaacaaat tggagcggca taaaaaaatc gagcttccgc gccttctgga 992821 gacggcagga gaatttttcc gtcctctgac tgacggaaac taccaaacca tttatttttc 992881 cgaaacggat gattcgatca tggttatgca tcgcgatggc actgtctatc atgcggaaga 992941 gctgtcacaa gggacgtgtg aacagctgta tacagcgatc cgctttgctt tggccgttac 993001 gcgccagggt gagtcaaagc ttccgttcca gcttgacgac agttttgttc attttgatca 993061 ggaaaggctg aaacgtgtat tacatgttct gtatgattta tctgaaggcg gtaggcagat 993121 tttgtatttt acatgccatg agcacgtaaa agatgcattt catagcagcc aaatcatcca 993181 tttggtgtca taaaagaggt tctatagctg aaaatcggta tgtgatatac tggtattatg 993241 taagatacgg agggagcttt aatagaatgg ctaaagggat tatgctacat gaggttggcg 993301 aacaggtgga ccagtatcta ttgattaaat cctcgacgaa agggattgca agcaatggaa 993361 aaccgtttct gacgctgatg ctgcaagacc agtcaggcga tattgaagcg aagctgtggg 993421 atgccaagca aagtgatgaa gtgacctatg cgccgcagac gattgtcaag gtcgtcggcg 993481 atgttcacca ttatcgcgga cgcacccagc tgaagctaag aaatatcaga ccggtaagcg 993541 agcaagaaaa cgtcaatatt gatgattttt tagaaaccgc gccgattccg aaaaatgaaa 993601 tgatggatac catcactcaa tatatatttg aaatgaaaaa tccgaatatc cagcgaatca 993661 caaggttttt ggttaaaaaa cacgaagctg agtttatgga ttatccggcg gctacgaaaa 993721 accaccatga gtttgtctca ggtttggcgt atcatgttgt ctctatgctg aacctggcga 993781 aagcaatagc agatttatat ccttctcttg atcgtgatct gctttacgcc ggtgttatcc 993841 tgcatgatct tggaaaagtg aaggagctgt ccggccctgt ttccacttca tatacggttg 993901 aaggcaattt gctcggccat atttccatca tggtgacaga gctttcaaaa gcggctgagg 993961 agcttcaaat cgattctgaa gaggtgttaa ttcttcagca tttgattttg agtcaccacg 994021 gcaaagcaga atggggcagc ccgaaaccgc ctatggtgaa agaagcggaa attcttcact 994081 atatagacaa tctggatgca aaaatgaata tgatggacag agcgcttgag cgcgtgaagc 994141 cgggcgagta tactgaacgt gtatttgcac tggaaaaccg ttccttttat aaaccgacat 994201 ttcataaata acttaaaaag gactgatgct gacatattca gctcagtcct ttttgatgcg 994261 tctttcccgc acataactcg tctcattccc gcatatggtt aagaataaag aatctatgca 994321 aagggggagg agcccgtgtt attttttccg tggtgggtgt atctttgtat tgtaggcatc 994381 attttcagcg catataaact tgtggcggca gccaaagagg aagaaaaagt agaccaggct 994441 tttattgaaa aagaaggaca gatttatatg gagaggatgg aaaaggagcg agaacgccgc 994501 agttctcagc agcatgaaga agaaaatcaa aaccattcca tcgcataaaa aaagctgtgc 994561 ggctcaatga gccgcacagc tttttttatt atttagaatt gcttgaagat gaagaagtgc 994621 tgttgcttgt tgaagatgta ttaaatgtgt ctttcagatc tttatctttt acttcgatgt 994681 cagccttctt catgactttt tgaacagctt cctgaacagc tgcgttgtca tttaattttt 994741 gttcaagcac ttcagatttc agttcttttt tcatatcatc atatttgccg cgttcttctg 994801 tctttttaat gatatggtag ccgtattgcg ttttgacagg atcactgact tcacctgttt 994861 ttaatttgaa tgcagctttg ctgaatgttt cgtccatttg gccttctttt gcgaaccagc 994921 caagatcccc gccttttgaa gcagagctgt ctgttgagta ttctttcgca aggtcttcaa 994981 acttctcgcc ttttttcagc tttttctcta cttcttcagc tgtcttttta tcagcaacaa 995041 ggatgtggct tgcacggatt ttgcctttta agccttccca gtactctttg atatcggcgt 995101 ctgttacttt gatgttatct ttagccgctt tttgtgtcag caattcatat tttacttgtt 995161 ctttcaggta atctttgcca tattgctttt cgagggcagt atattgatcg ccaagctgcg 995221 ttttgtattc tttcagcttg ttgtcaattt ctttatccga aactttatac ttcttgtcca 995281 atactttttc ttgcactagc tgtgtcagta cgcttgcgcc agctgttttc ttcatgtttg 995341 tgtaaagctc gccttttgtg acatcgcctg cgtctgtttt tgcgataact tctttgtcgc 995401 cgctgctgca agcactgaga gcgaggatgc ttgtagcagt gatagctgct attgcgattt 995461 tcttcattgt tttcaaacac tcctaatcat tccaaattaa attacctatg cgtatcataa 995521 catattgtgg ctttctgtaa aaagatttta aataaagggc attcgtctag tcaaactttt 995581 gctgatgaca tacttatata ttgatcaaga aaaggaggta tgtaacatga gcggaggata 995641 ctctaacgga ttcgcgttgc tcgtagtact gttcattttg cttatcatcg taggtgcagc 995701 ttacatctac taagcagccc gaggatcgct tgcaacataa gcgatccttt attttcacta 995761 gcgcctaatc gtttcaaaca tgaattgcat aacatgtaat tggtaaataa agcttattac 995821 aggaggtgct atttaagatg ggtgaagtat ttgcaggcgg attcgcttta ttggttgtgt 995881 tatttatttt attgattatc atcggcgctt cttggctgta ctaatcaaca taaaaaagca 995941 tagctgctta atcagcagct atgctttctt tcgtatttac actgtaaagg agatctccac 996001 aaacgaagag atcagtaaaa ttaatataga tacattaata aatcggaata ccttatcttg 996061 ccgctcttca ggaatctctc tgacaaggca taatgtattg gtgagcctgt ttatgaaata 996121 taaaataaac acggcagcca cgataaaata gaataaaatg atgggagatt ccccctctct 996181 ctgaactgtc ccatattaca ttaccaaata tttattaaaa aagatagaat gcaaattgaa 996241 aaatcgccac cagcaccagg gtttgactac ttttcaacaa gaatatccaa gccgtcagct 996301 tcctgatcaa taaaagcggt tttcggtgct tttatcagct tgagagccag caggaaatca 996361 ggcagacagt agccggcgtg aatgcccgag atcatgcaaa aataatgagc gtgattcgga 996421 aatgccagtg ctgcgtaaaa caataccggt gtaatcagca agaacgggct gacgagtgaa 996481 atcagcattg ttgtttttgg tatacgtttc catgtgcgca tgcgcaatat gtaaaacttt 996541 ttttctattt ttcttttttt gcagatgatt ggcaggacat ggatgacttt atgtacaaat 996601 aaaataacga cgagcaaacc gccgaataaa gatacatatt catcgcttaa gcttgtgcca 996661 ggccgcagca gctcaaaagc taaaaaggta gatataaaaa ccaaaatcat aaaacataca 996721 gcagttaata ttatgcgaac ggcgccataa tccttcatga gatttatggt cttccagcaa 996781 ttcatcaaag tcatccttcc atacatcttg aatagaatct caaaataatt tactcctccc 996841 aagagaaaaa atcaatgctt ttttaagaaa aaatatcatc cggcaggtat ttttttgaaa 996901 caagcaaaca aactgcgaaa tatggggtta gaactttctt ctcagtgaat tatcagctaa 996961 aataagatta aagatagaaa gaagtggtgt ggatggattc gatggatcat cgcattgagc 997021 gattagaata ttacatacaa ttattagtga aaacagtaga tatggacagg taccccttct 997081 atgcgcttct cattgataaa gggctgagca aggaagaagg ggaagcggtt atgaggatat 997141 gcgacgaatt gtcggaagag ctggcaacac aaaaagcgca aggatttgta acctttgata 997201 agctccttgc gctttttgcc ggacagctga atgaaaaatt agatgttcat gaaacaattt 997261 ttgccctgta tgagcagggg ctttatcaag agctgatgga agtctttatc gacatcatga 997321 agcattttga ttaactgttt acaggttcga gctcttcagc cggttcatcc gccgcactgt 997381 cctttgcttt tttcttcaat tttccgttta cgctttcaaa gtcattgtca atattggtga 997441 gtgacgtttc gaaaatttcc ataaaatcat cgccgtagat atggcgtatc atacacatca 997501 tttctgccac ttcaggaaat tttccgaata aatgatataa aggctgtgac cctttaaaaa 997561 cagcgttgcg tgtcggatca aattcctcaa gcaagctcca gaatacctcg gtaccttcct 997621 cagtcaattg gacatatgtg ttccgtttat cattcagccg tttggagaac cttaaatatc 997681 cccgttcttc cagctttttt gaaaagttga atgcggttga tacgtgcatg accccgaatt 997741 tcgcgatttc agaaatggaa gctccattca attgatacgc aatccataaa atatgatgct 997801 cattaatatt caggtcatac ggtttgagcc attgctgcca atccttctcg atcgatttcc 997861 aaagagcctt gctaagctga gccattttct gggtgaaaac cagagcttct ttcacatcat 997921 agggcggttc cactcgattc attacgtcac ctgcttctct ttttcttttt ctctattatg 997981 ccaataaaat aaagattaat aaagatgaaa atgtaagaat tttttaataa attcacaaac 998041 cattgcgacg aaagggtttt tcggccaaaa aaaatacggg tccaattttg gcccgcattt 998101 ttttcttttg aataggatat tagttttgta aggttttctc cagctgtctg attttctctt 998161 cgatatcggc aatttctttt tgcagatcct gctggtgagg cttgatctct tcctgccatt 998221 ttttaattga tgtttggagc tcgccgccca cgtctttaat aacatccgtg ctttcttttg 998281 ccgctttgat cagctggtct tttaatgcaa gcccgtctga ctttaagcgt ttgattgttt 998341 cttcaaaaga atcataattg gttttcattt tttcacgcag ctgctttcct gaggaaggtg 998401 cagtaagaag aaccgctgct cctccgatga tgccgcctac gaatagtcct gttaatagag 998461 aacgtccgct cgccattaca atcaccccgt ctttttcttc aaaataggat tcattcagca 998521 tttttcattt ttgttgaaag cctgaacttc tatacatagc ttgctttatt ttagcatatt 998581 ttttaagtga aaaggaggga gaaggttgtc tgtctttttg attgtattat cctgcatcac 998641 ccttgccttc gcttcaggcg ctgtttacta tatcaaactt ctcagccagg ctgcttctta 998701 tccgcccaag agggttatcc ggcagaaagc gcttgtttgt tcaaccggaa ccgcctttac 998761 actatgtctt atctttttca caaaactcct cgcttaaaac atgctgacat gctgcgggcg 998821 ctctgttcaa aaaaacctct cccggaagcg gaagaggttt tgtgtgacaa ttatttagca 998881 gcttccataa agcttgaacg ccttaaaatg gtttgcacaa tcggataaat aatgatcatt 998941 gagattgtat tcagcacagc ggccggcaga acaacagccg cgaacaatgc ggcgaaaccg 999001 cccggtaaac cgacgatcaa taaagctgac gatagaaaca caattcctga taagatggtc 999061 ccgatcactg tcagcacagc ggctgcacct gttttccggc tctttctgaa caagagaaac 999121 agggagaaga acagaaacgc tgatacgggt ttatcaatga tgttagggat ctgtccggct 999181 ggaaacgcgg ttgtaagcgc ggaaatgatt ccggtcacga tcccgatgac gagtacattt 999241 tgcacccgcg ggaacagcag aatgcccatg aacatcatga tcagcatcat atctggtttc 999301 atgccgccta aaaagggcgg aataatggaa tgaagcgctg cgccgattgc ggcaaacaga 999361 gccataatga ctaactcttt tgttttcata actatgctct cctctgctaa gctttttgcc 999421 ctccaataat atgctcatca tttattgcga aggctttaca gaatgtgtta tgcaaacagt 999481 ataccaaacg gacggtttgc atagccagac tttttactca ttttcctgct ggaatttctt 999541 catgaacgca gctaattttt cacagtcttc gagagagacc gcgttataaa tagaagcgcg 999601 gcagcctccc accgaacggt gtccgccaag gccgatcatc ttcgcatctt ttgctttctg 999661 aacgaatgtt ttcgttaatt cgtcatcccg aagcgtgaat gtgacattca tgcgtgagcg 999721 gctgtctttt ctggcatgtc ctttatagaa gccgttgctt tcatcaatac agctgtagag 999781 aacctgcgct ttttgttcat tgcgctgttc aacagcttcc acaccgccgt tttccttgag 999841 ccattccaga acgaggctca gcatataaat cgcaaatgtc ggcggagtgt tgtagagtga 999901 atccgctttg acatgcgtgg aatatttcaa gatttttggg acgttcgcat tttcattttg 999961 cagccagctt tttttcatga tgactacagt cacgccggaa gggccgaggt tcttttgggc 1000021 gcctccgtag atcacatcaa atttggacac atcgattttt ctgcttaaaa tatcgctgga 1000081 catgtcggct acgagcggaa ttggagaatt cggaaactcc tgccactgag tgccgaaaat 1000141 tgtattgttg gatgtgatat gtaaatatgc gccgtctttt acatccgtaa ggtcaacctc 1000201 tggaatataa ctgtaattgt ctgtttcact tgtagcggtg atagacgtgt tcccgaacag 1000261 tttcgtttct gccagtgctt tttcagacca agcgccggtc atcacaaaat gtgcggtttt 1000321 ttcaggtgtt aaaaagttca tcggaagcat tgagaattga aggcttgccc cgccttgaag 1000381 aaacaagata tcgtaatctt ccggaatgcc catcagttcg attaagaggc ttttcgcttt 1000441 ttggtgcacc gcttcatact ctttgctgcg gtgggaaagc tccataacag acatgccgga 1000501 ttcgttaaaa tcaataaatt ctttctgtgc tttttgcaga acttccagtg gcagcgctgc 1000561 aggacctgcg ttaaaattcg ttgtacgttc cattatgatc tctccctgtt ttccacgtta 1000621 atgtataaaa taatacaatt atcctatcac aaaaattcag ttttttgata aaaaattaga 1000681 attatcaaaa gaaattgacg gatgtttgcg aaatgttcac aaaataaaat aacctcatct 1000741 tatgatgagg ccaggcgttt tgcgatagag gaagagatgt tctgcagatc ctccggttta 1000801 taatcatcag catgcgtttt ccaaaccgct ccgaatccat ctccttttcc gtagcgaggg 1000861 ataatatgca tatggtagtg gaacacagat tgtccagctt tttcgccgtt attgttcagc 1000921 gtatttaagc cgatcggttc aaattcatcc cggatagcgc gggcgatttt tggaacagca 1000981 tggaaatatt gttttgctaa ttcatctgta aattcatata cattctcaat atgtgttttc 1001041 ggaatgacaa gcgtatggcc ttttgtcact tggctgatat caagaaaggc aagtacatgt 1001101 tcatcttcat acaccttcgc tgatggaatg tcgccggcaa taattttaca aaagatacaa 1001161 ttctctgcac aatgcatgag ggttcctcct tatgaaattg tttagtatgt atacattcat 1001221 cgtaccacag aaatgcagaa aatagaaaac aggatgaacg gcgagcgttc accctgaatg 1001281 cagaggaaga gcttatatga agaaaatgtg ttatgccttt ggtaagcacc tcatttgtca 1001341 ataaaatgaa gacttgttta atgcctaacg attcctgcga taaacacctc atttgacaat 1001401 ttgcttcata catgaagaat tcatcaattc agtgaagaga aatggtttga gcattggaca 1001461 tgtttatttt ctatccaact gtttctaaga cgtctttgac aaacacctca tttttcagtt 1001521 gatatgcttt tcctctacaa cttttatgat gtccagaacc ctgtctcttt atgacagcaa 1001581 attcatcatt tgttaaaagg gaattgtttc aaatcaggcc ttgtttttgg tactatgaag 1001641 aaaaacacta taaggggaga aactatgtct ctgctatcgg taaaagactt gaccggcgga 1001701 tatacaagga atccggtttt aaaaaacgta tcattcaccc ttgaaccgaa tcaaattgtc 1001761 ggcttaatcg ggctgaatgg tgctggtaaa agtacaacaa tcagacacat catcgggctg 1001821 atggacccgc ataaaggttc aatcgaatta aacggtaaaa cgtttgctga ggatccggaa 1001881 ggctaccgtt cacaatttac ctatatacct gaaacacctg ttttatacga agaattgacg 1001941 ctgatggagc atcttgaact aacagccatg gcatatggac tgtcaaaaga aacgatggag 1002001 aaaaggctgc ctccgctact aaaggaattc cgaatggaaa agaggctgaa gtggttcccg 1002061 gcccattttt ctaaaggaat gaagcagaag gttatgatta tgtgcgcatt tttggcagag 1002121 cctgcgctct acattattga tgagcctttt ctagggcttg atccgcttgc cattaacgcg 1002181 ctgcttgaac ggatgaatga agcgaaaaaa ggcggggcga gcgtgctgat gtcaacacac 1002241 attttggcaa cggcagaacg ctattgcgat tcgtttatta ttttacataa cggcgaggtg 1002301 cgggcgcgcg gcacgctgtc agagctcaga gagcagtttg gaatgaagga cgcggcgctg 1002361 gacgatttgt atcttgagct tacaaaggaa gacgctggcc atgaataata tgcttgatat 1002421 ttggcagtcg cggctgcagg agcatatcaa agaaacaaga acatacatga aatatatgct 1002481 caacgatcac ctcgtcattg ttttgatttt ttttctagcg ggcgctgcaa gctggtacag 1002541 caaatggata cgggacattc ccgctcactt tccgtccttt tgggtgatgg ccgtgctgtt 1002601 ttcgctcgta ttgacaagct cttatgtgcg aacgcttttg aaggaggctg accttgtttt 1002661 cttattgcct cttgaagcaa aaatggagcc ttacttgaag caggcgtttg tctacagcta 1002721 tgtgtctcag ctgtttccgc tgattgcgct gagcatcgtt gcgatgccgc tttatttcgc 1002781 agtcactccg ggagcttcgc tcgtatcgta tgccgcggtc tttgtccaac tgttgctgct 1002841 gaaagcgtgg aatcaggtaa tggaatggcg aacgactttc caaaacgacc gcagcatgaa 1002901 acggatggac gtcatcattc gctttgcggc gaatacactc gttctttatt ttgttttcca 1002961 atctgtttat atgtatgcgc ttctcgtcta tgtcattatg gctgttcttt atctgtatat 1003021 gtcttccgca gcaaaacgga aaacatttaa atgggagagc catattgagt ccgaattgag 1003081 acgaaagcag cgtttctatc ggattgccaa cctgtttact gatgtgccgc atttgcgaaa 1003141 gcaagccaaa cgcagagctt atctcgactt tttgctgcgg cttgtgccgt ttgaacagcg 1003201 caaaacattt gcctatatgt tcacccgcgc ctttttgcgt tcgagcgatt atttgggcat 1003261 tcttgtcaga ttaacgatcg ttttcgcgct gatcattatg tatgtctcag ccagcccgct 1003321 gattgccgcg gttttgactg tgtttgccat tttcattacg ggcattcagc ttctgccgct 1003381 cttcggtcac tttgaccatc tggcgcttca agagctgtac cctgtgcaaa aagaaacaaa 1003441 gctgaaaagc tatttctctc tattaaaaac tgcacttagt attcaagcgc tgctgatgtc 1003501 tgttgcatct gcctatgcag ccggcttgac cggttttctg tacgcgctga tcggttctgc 1003561 cgttctgatt tttgttgttt tgcctgctta tatgacgacc aggctgaaaa agcacggaaa 1003621 gctgtgaact gaaaagaggt aatcaaatga cagataatca gctgctgatg caggaagctt 1003681 tggaatggaa aatgcatttt ttgcgaaagg attccatgtt tgaacgcttt tcgaagcgtg 1003741 tccagacgaa ggtgaatgaa cggattcctg aaaaaatcca tacggtcgtc accgagagtg 1003801 tgaaaaaaat ggtagaagcg acaatggccg gctctaatat catcacctat aaaaaggata 1003861 caagtgcact gtcgctcagt gaaaaaaacg aattggcgaa aaaaacgatt gtttcttatc 1003921 aaaaagtggc agctgctgag ggagtcggca ccggagcggg cggcattttt ttaagcattg 1003981 ctgattttcc gctgctgctt tcaattaaga tgaagtgttt atttaccttg tcttccattt 1004041 acggctttga tgtcaaggat gcacaagaaa ggatattttt gctgctcgtg tttcagcttg 1004101 cgttttcgag tgatgatggc cgtaagtcgc ttttttctgt catcgaaaat tgggagacgg 1004161 agaaaaagag catcgactgg agagtgttcc agcaggaata tcgcgattat atcgacgtcg 1004221 tgaagctttt tcagcttttg ccgggcgtag gagcggcagt cggcggaatt gccaattata 1004281 agctgcttgc tcagcttgga gaaacggcaa gacatgtttt tcatctgagg atattaaagg 1004341 aaacagccgg agaataaaca ctccggctgt ttttttatag ctgatgatag gtgatcgcag 1004401 cgccggcaag gaccttggcc gctgtcagca tggctttttc gttgatatca aatttcggat 1004461 ggtggtggga atagactcgc tctggctgtt cgggagcggc gcctgtaaag aaaaaagtgc 1004521 ccttcacgtt ttgtaagtaa taagcaaaat cctcgccgcc catttgtggt tcaccgtcaa 1004581 tgacctgctg aacgccctcg gtattctttg cggtgctcac caagtggttc gtttctgcag 1004641 gatggttcac aaccgctgga taaccctgtt cataggtgta ctcataggac gcgccgtgca 1004701 tgctgcatat tccttttaca accgcttcaa tttctttctc cagaatgtcc cggacatttt 1004761 catcaaaaga acgcgctgtg ccgatgagta ctgcttggtc tgcgatgaca ttaaacggat 1004821 tgtcggcgat gaaggagcct gtcgaaatga cggcggattg aatcggattg actttgcggc 1004881 tgacaatgtg ctgcaaagag gaaacgattt gcgaaccgat taggacggcg tctttagtat 1004941 catgcggatg agcgccgtgg ccgccctttc cgaagacttt aatcgtaaat cggtctgccg 1005001 ccgccattac ggcgccgggg cggcagagaa tagttccgag cggctcagtt gcccaaagat 1005061 gagtgccgaa tatcacatcc gtgttttcga gacatccgtc atcaatcatt ggctttgcgc 1005121 ctccaggata atattcttct gcatgctggt ggatcatcac aaatgttccc ttcagttcat 1005181 gtctgttttg gtgaaggacc ttggccactg cgagaagagc tgcggtgtgg ccgtcgtggc 1005241 cgcatgcatg catgacacca ggcactttgg aggcgtaagg gacatctttt tcatcttgaa 1005301 tggggagagc gtcaaagtcg gccctcaaag cgactgtagg gccgggttcg cttccttcta 1005361 tatttgctaa aacccctcta ccgccaacgt ttgtgcggat tgggactcct aacgattcat 1005421 aataggaagc aataaatgcg gcggtttttt cttcttgaaa tgagagctca ggatacatat 1005481 gaaaatggcg cctgatctca accatttctt caaaacagcc gtcgagctgt ttgtttatct 1005541 ctttctgcag tgtggatatg gacaaagccg cttccccctt ttctatgctt ttccatgatt 1005601 gtatagaaaa agtctgaata tttcaactca tgctgtttta aagcatcatc acagctgcga 1005661 gggttgtcac caaaaggcca atcgcgacgg gaatgaagtt ttttctggca agctcaaaag 1005721 gatcaacttt gcaaatggcc gcggcgggaa tcaaagccca tgggaccagt gttcctccgc 1005781 ccacccagat ggcagagatt tgtccgagcg cggtcagaat agcgggatcg gcatggagag 1005841 cggacgaaaa gagctttgcg atggagccgg cgagagaaat gccagaaaat cctgagccgt 1005901 caaggcctgt tatggctcca gcggcagtta atgcagtggc ggcaagctcc tttgacatag 1005961 gcatcatatg ggataaagca atgccaagat cgttgacaat gccgtgggaa cctttaggga 1006021 gtgaagtgcc cagtatgctt tcatagcctg agtcgccaag ataaaagaaa gcggcaatcg 1006081 ggatgacggg gccgaaaacc ttaaaaccga acttaaatcc gtcaataaaa tagccggtga 1006141 ttttttcaag ccctttatgc ttatacacga aaaaatgaac ggtaaagagg atacaaattg 1006201 cagacccgcc aattaacgcg gttgcatcat ttccttgtag gttaaacaag agcatgcagg 1006261 cgatatctgc aagaaaggca agcggaatca aaaaagccag tatggaccgc aggcgttttg 1006321 gcaagtacag cgagttgtct tgttcgccgg aaagaacggg ggaaaaagaa gtgggatgct 1006381 cctgtttttt gcgttcgcgc tgaatcatga taaaggcagc agttgttgtt gtcacaccca 1006441 taatcagcac aagcggaata ctggccgaga cgacatcacc gactggaatg cctgctgcat 1006501 ccgcagtcag ctttggcgcc gcctgaatga caaagtctcc tgacagggca aaaccgtgtc 1006561 cgaataagtt catggccatg gccgcggcaa gaggcgtcaa accggcacgt gcggctgcgg 1006621 ggagcaggac ggcgccgatc aaagcgacac ccggagaagg ccagaagaat agagaaatgg 1006681 cgaacatcag gcctccaatc agccaatagg cagtcacagg ccctctcaca aggcttgcaa 1006741 agggagaaat catcgcttca tttatccctg tttttgttaa caaatcactc attgaaacga 1006801 taaagcaaat gatgaaaatc gtgggcagca gttcgccggc cgcatagata aagctgtgga 1006861 ataaactgct gacagaagct gaaagtgaat ggctggccca tagcgatatg ataaaaatgc 1006921 cgaatagaga aataaatgtc gtgtcttttc tcagcagcat aaataggata attgcaccga 1006981 taaaaaacac atacagaaca tggacaggca aaatcccgac ttccatcatc gatcactcct 1007041 tccgcttaca gattattcat aggcgggcgg aaggtgccgg gacagagggg agggttatga 1007101 tggaagatga acattgatct gtttcagctg ctcaatcaga tgatgcctta atcctctatt 1007161 cgctttttgc agatgttttg ggaagcattc aggagaaaaa atgacgcacc cttcagcaag 1007221 ccagtttttt ctataggcga tgatgctttc cgatggctct atatgagtta tcctcgtgct 1007281 gcatctcgta ctcatcaaat ccgaactgaa aaccgcagca cgggcagatt tcatgagaat 1007341 gattgccttc atgatcatat ggcggttcag ccaatcctta aacccgcaga ctgggcaagt 1007401 atgcttcatt ttgctttcct cccaataaaa taagctgccg gacatgccgg cagctattcg 1007461 acagcgaaat atgtggtgac ataggaaggc cgggagaaga tcgacgttgt gtcaattccg 1007521 gcagatgtat cgcgtttttt gtgggcttct ttgtaagaac cggactgctg ccagtcttga 1007581 aaggcgcttt ccgtttccca caaggtcaga atgacatagg tgtcactgtc aagcggacgg 1007641 agcactcgaa ttgcttcaaa gccaggctcg ttttcgactt ttcccgctct gtttttaaat 1007701 ctgttttcaa acagcggacg cccttcctga gtaacggcaa tattgttcaa tactgcaaaa 1007761 ccgggatgtt tgatctctcc gacttggtca atgacttcat aagcgtgtgg tgcctggaaa 1007821 acggtatctc cgtttgtttc atgaattaaa atggcgtttt cctgcccctg catcaaaagg 1007881 atattttctg agggatgctt ctgtacgatc gtttttaaaa aatcggctgt cccatatgta 1007941 atataaacct tcatatcagc cacctcctgc ttgctagtat atcaaaacaa tggtataagt 1008001 ttctattggc gagtgcttcg aacataattc caaacaattt ttcccatact acctttagaa 1008061 aggcgaggtg agttcatgtt taagataaag aaaaagaaac tttttatacc tatcattatt 1008121 ttagtgttaa ctgcttttct cgctttaata ggatatattt caattatttt tctcggccat 1008181 tatgtcatag atgaaaaaaa gcttattctt catgcttctt caaaaattgt tgatcaaaac 1008241 ggagatgagg ttgcaagcct gtatacagaa aatcgcgagc cggtctcgat caatgagatt 1008301 cctaagcagg tcagagaagc gtttatcgct gttgaggata aaaggttcta tgagcatcac 1008361 ggcattgatg caaaatccgt cggaagggca gtgtaccgcg atatattagc aggcggaaag 1008421 gtggaaggcg gaagcacgat cacccagcag cttgccaaaa atatttttct gacacatgac 1008481 aaaacatttc taagaaaaac aaaagaagtg atcattgcga ttaatcttga acgggattac 1008541 agcaaggaca agctgcttga aatgtattta aaccagcttt acttcggaca cggggtttac 1008601 ggcatacaag cggcgtccca ctattatttt aataaagaag taaaagattt gactgtatct 1008661 gaaggcgctg ttttggccgc tattccgaag gcgccttcta cgtactctcc aattttgcac 1008721 cctgataaaa ataaggagcg gcgtgataca attctaggta tgatgaatga ccaaggctat 1008781 atcagtgcga aagaggctgt caccgcacag ggccggacgc ttggactgca tgtgaagaaa 1008841 cagtcggaaa caccttggtt tgacagctac attgaccttg tgatcaaaga ggcggaagac 1008901 aagtattcca tttccggaga gcagcttctt caaggcggat acacgatcaa ggtgccgctc 1008961 gattcgaagc tgcagaagac ggcttaccag gtgatgaaag agggaagcta ttatcccgga 1009021 acagatcaga atgccgaggg aagcgcggtc tttattaata acaagacagg cggtgtagaa 1009081 gcggccatcg gcggaaggga ttacacatcc aaaggatata accgtgtcac agctgtccgc 1009141 cagccgggtt ccacatttaa gccgcttgct gtatacggac cggcgatgca ggaaaagaaa 1009201 tttaagccat attctctatt gaaggatgag ttgcagtcct acggagatta tacgccgaaa 1009261 aactacgaca gccggtatga gggcgaagtc actatgtctg acgccattac gtacagcaaa 1009321 aacgcgccgg ctgtctggac gctgaatgag atcggcgtcg aaacagggaa atcttatttg 1009381 aaagcaaacg gcattgatat ccctgatgaa ggccttgctc ttgctctagg cggcttggaa 1009441 aaaggcgttt caccgctcca gcttgccggc gcgtttcata catttgccgc gaatggaacg 1009501 tatactgaac ccttctttat ctcgagcata atagatgaag acggagaaac aatagccgat 1009561 cataaagaag aaggaaagcg ggtattcagc aagcagacgt cttggaatat gacgagaatg 1009621 ctgcagcagg tagtcaaaaa gggaacggcc acgtccggca cctatcacgg cgacctggcg 1009681 ggaaaaacag gttcaacatc ttatacaggc gtctccggcg cgacaaagga cgcctggttt 1009741 gcaggctata cgccgaaaat aaccggggca gtctggatgg gctatgacaa aacggatcaa 1009801 aaccattatt tgaaagccgg gagctcatac ccgacgcggc tgtttaagga tattttgaca 1009861 caggcaggag aaaccggtca tgtgttcaca aagcctaaaa acgttaaaga actggaaagc 1009921 ccgattgagc tgaagccggt caaaacactc acagccgatt acacatttaa agcagcgggg 1009981 ctctttacta ttgaattaaa gtgggacgct caagaggatg atcgggccgt atacagaatt 1010041 tatgtaaaca aggacggcga ggagacgctt cttgattcgg ttgaagggaa gggaagctat 1010101 gaaattcctt atgccaactt attttcgggc gcgtcttata aaattgtgcc ttataataca 1010161 cagacaaaaa gagaagggga aggaaccgat tacgttcagc caaaattgtt ttcctcttaa 1010221 tggaattcgg cgattttttg aactttgagc tacatttcta taccatttgc ctaaaacaag 1010281 gtatagtgta ataagtcaag aaatacgaac gtatggttgc cgtatgaaag gtggaaatca 1010341 gatgagtaaa cgagaaacgt ttaacgagac gtttttaaaa gctgcgcggg gagaaaaagc 1010401 ggatcacacg cctgtgtggt atatgaggca agcagggcgc tcacagccgg aataccgcaa 1010461 gctgaaggaa aagtacggat tgtttgagat cacacatcag cccgaacttt gtgcgtatgt 1010521 cacaagactg ccggttgagc aatacggagt cgatgctgca atcctttata aagatatcat 1010581 gacgccgctg ccgtcaatcg gtgtggatgt tgaaatcaaa aacgggatcg gtcctgtgat 1010641 tgatcagcca atccggtctc tggcggacat tgaaaaactc ggccagattg atccggaaca 1010701 ggacgtgccg tacgtgcttg agacgattaa actgcttgtc aatgagcagc tgaacgtccc 1010761 gctcatcggt ttctcaggtg cgccttttac gcttgcaagc tatatgatcg aaggcggccc 1010821 gtcgaaaaac tacaataaaa caaaagcctt catgtacagc atgccagatg catggaatct 1010881 gctgatgtcc aagcttgccg acatgatcat cgtgtacgtg aaagcgcaga ttgaggcagg 1010941 cgcaaaagcg attcaaatct ttgattcgtg ggtcggcgca ttgaatcagg cagattacag 1011001 aacatacatc aaacccgtga tgaaccggat cttttcagag ctcgcaaagg agaatgtgcc 1011061 gctgatcatg tttggcgttg gcgcaagcca tcttgcaggt gattggcatg accttcctct 1011121 cgatgttgtc gggcttgact ggagactcgg cattgatgaa gccagatcaa aaggaattac 1011181 taaaacagtg cagggcaacc tggacccgtc cattttgctt gcgccatggg aagtcattga 1011241 gcagaaaacg aaggaaatac ttgatcaggg tatggagtca gacggcttca ttttcaatct 1011301 tggccatggg gtatttcctg atgtcagtcc cgaggttttg aaaaaactga cagcatttgt 1011361 ccatgaatat tcacaaaaca aaaaaatggg tcaatattcc taagcatatc ttttggtatc 1011421 ttaatgatat cctgtcaaaa tgtttgtatc agatcattaa agagggtgta aacagtgagt 1011481 agaaagaaaa tggggcttct cgtgatggcg tacggcacgc cttataagga agaagatatt 1011541 gaacgttatt atacacatat cagaagaggc agaaagcctg aacctgaaat gcttcaagat 1011601 ttgaaagaca gatacgaagc gattggcggc atttcaccgc ttgcccaaat cacagaacag 1011661 caggcgcata atctggaaca gcacttgaat gaaattcagg atgagattac gtttaaagcg 1011721 tatatcggac tgaagcatat cgagccgttt attgaagacg ccgtagcaga gatgcataag 1011781 gatggcatta cagaagcagt cagcatcgtg ctggcgccgc atttctccac gttcagcgtt 1011841 cagtcctaca acaaacgcgc caaagaagag gctgaaaaac tcggcggctt aacgattacg 1011901 tcagttgaaa gctggtacga tgaaccgaag ttcgtgacat attgggttga ccgagtgaag 1011961 gaaacatatg cgtcaatgcc tgaggatgaa agagaaaacg caatgctcat cgtatccgca 1012021 cacagcctgc cggaaaaaat caaagaattt ggagacccgt acccggacca gcttcatgaa 1012081 tcggcgaaat taattgctga aggcgcaggc gtttccgaat atgctgtcgg ctggcaaagt 1012141 gaagggaaca cgcctgatcc ttggctcgga cccgatgttc aggatttaac acgtgattta 1012201 ttcgaacaaa aaggctatca agcatttgta tatgttcctg ttgggtttgt cgcggatcac 1012261 ttagaagtgc tttatgataa tgattatgaa tgcaaagtgg ttactgacga tatcggcgca 1012321 agctattacc ggccggaaat gccaaatgcc aagcctgaat ttattgatgc tttggcaaca 1012381 gtcgtattaa aaaaattagg acgttaaaga aggcgatgaa catgagtgac ggcaaaaaac 1012441 atgtagtcat catcggcggc ggcattaccg gtttagccgc cgccttctat atggaaaaag 1012501 aaatcaaaga aaagaatctg ccgcttgagc tgacacttgt tgaggcaagt ccgagagtcg 1012561 gcgggaaaat ccagactgtc aagaaagacg gctatatcat cgaaagaggg ccagactcat 1012621 ttctggaacg aaagaaaagc gccccgcagc ttgttaaaga cttaggtctt gagcatttgc 1012681 ttgtcaacaa tgcgaccggg caatcctatg tgcttgtaaa ccgcaccctg catccaatgc 1012741 cgaagggcgc tgtaatgggg ataccgacaa aaattgcgcc gtttgtttct acgggtctgt 1012801 tttccttgtc cgggaaggcg agagctgcta tggatttcat cctgcctgca agcaaaacaa 1012861 aggatgatca gtcattggga gaattcttcc gcagacgtgt cggagatgaa gtggtcgaga 1012921 acttaatcga gccgctacta tcagggatct acgcaggcga cattgacaag ctcagcctga 1012981 tgtcgacatt tccgcaattt tatcagacgg aacaaaagca tagaagcctg attctcggca 1013041 tgaaaaaaac aaggcctcaa ggctcaggcc agcagctgac ggcaaaaaaa caagggcagt 1013101 tccaaactct gtcaaccggt ttgcagaccc ttgtagaaga gatcgaaaag cagttaaagc 1013161 tgacgaaggt gtataaaggc acaaaagtga ccaaacttag ccatagcggc tcttgctatt 1013221 cgctcgaact ggataacggc gtcacacttg atgctgattc agtaattgtg actgctccgc 1013281 ataaagcggc tgcgggaatg ctttctgagc ttcctgccat ttctcatttg aaaaatatgc 1013341 actccacatc cgtggcaaac gtcgctttag gtttccctga aggctccgtc caaatggagc 1013401 atgagggcac gggttttgtc atttcaagaa acagtgactt tgcgatcaca gcctgtacgt 1013461 ggacgaataa aaaatggccg cacgcagcgc cggaaggcaa aacgctgctt cgggcatatg 1013521 tcggaaaagc cggagacgaa tccattgtcg atctatcaga taatgacatt atcaacattg 1013581 tgttagaaga cttaaagaaa gtcatgaaca taaacggcga gccggaaatg acatgtgtaa 1013641 cccgatggca tgaaagcatg ccgcagtacc atgtcggcca taagcagcgt atcaaggagc 1013701 tgcgtgaagc acttgcatct gcgtatccgg gtgtttatat gacaggcgct tctttcgaag 1013761 gtgtcggcat tcccgactgc attgatcaag gaaaagctgc cgtgtctgac gcgcttacct 1013821 atttattcag ctaaaacctc cgctttatcg cggaggtttt tttgatgtgc aatggcaata 1013881 ttgtgtaaaa aatgattgaa ttgaacagca ggttatgata catttgcata tgtacttaat 1013941 gactaaaatg ttcaaacggt cagtttcgag gtgaatacaa tgtcaataga tcgaaaaaag 1014001 ctcattttgg aggcggctac aaagtctttc acgcagttcg ggtataaagc gacgacaatg 1014061 gatcttgtcg caaaacttgc gaacgtgggg aagggaacca tttatacttt tttcaaaaac 1014121 aaagaagagc tgtttgacga gattttcact actttattaa aggaaatgaa gcaaaaagcg 1014181 gatgaagcga tggagccgag ccttccgttc catgaaaatg tgcacagagc gctgtttgcc 1014241 attctggagt tcaggaaaac acatcagctg acgattaaaa ttttccaaga gaatgccgag 1014301 attggtacaa tggcagttca ggaagtgatc cagaaaatgg agcgatccat cctgtcttat 1014361 atcaaaagca agattgaaga cgggatcaaa agcggcgcaa tcaagccgtg cgaccctgag 1014421 ctgacagcct ttgtgatgct gaagctttat atcgcgctca tttttgactg ggaaaaacaa 1014481 caccccccgc ttgataaaga gacaattgcg ggactgcttg aattgtatgt tgtcaaagga 1014541 ttgtcagcga actagataat cctttctctt tgcaagaaaa tgaccatttt ttatgatgag 1014601 tcagttttag aatggaggca tcaggatgaa cacaatacga agtcagtgga aagacatcgt 1014661 aacaagtaaa aaattattga ttcccatcat cgccattttg tttgtcccgc ttatttacag 1014721 cggcgtattc ttaaaggctt attgggaccc gtacggcaca gttgaccagc tgcctgtcgt 1014781 tgtcgtcaac caagacaagg gagcaacgta tgaaggagaa aaacttcaaa tcggtgatga 1014841 tctggtcaaa gaattaaagg ataataacaa ctttgattgg catttttcca atgatctcga 1014901 ccaatcgtta aaggacttat tgaatcaaaa atattattta gttgtcgaga ttcctgagga 1014961 tttttctaag aatgccagca ctgtattaga caaaaatccg aaaaaattgg atctgaaata 1015021 ccatacaaat gcaggttcta actatgtagg ggcaacgatc ggcgaaaaag cgattgataa 1015081 actgaaagcc tctgtttcaa aagaagtgac cgagcaatat acgaaagtta tttttgataa 1015141 ctttaaagat atcgcaaaag gtttgagcga cgcgagcagc ggcgcgaaaa aaattgatga 1015201 cggcacaaag gatgcgaaaa acggaagcgc ccagctgaaa gaaaatctgg cgaagctgaa 1015261 ggaaagcacc gctaccatca gtgacaaaac agcgcagctt gcagatggag cggctcaggt 1015321 gacgagcggc atccaatcac ttgacagctc gctcggtaaa ttccaggaca gcagcaacca 1015381 gatttatgat aaatctagtc agcttgcagc aggatcaggc gagctgacaa gcaagatgaa 1015441 tgaacttctt gccggacttc aaaatgtgca gaagggtacg cctaatctta ctaacgggtt 1015501 ggatcagctc aacagtaaag tccaagaagg ttctgagaaa gcggcaaaag cggaaaagat 1015561 cattaatgcg ctcgatttaa cgaagcttga aactgctgta aacaatctgg aaaagtcaga 1015621 aactgcgatg aaggaattca aaaaacagct gactgacttt gaaaacagtt tgaaaaaccg 1015681 tgatcaggca tttaaaaatg tcatcaattc gagtgacttc ttaacagcgg agcaaaaaag 1015741 ccagctgatt aattctgttg agaaaaagct tccgcaagtt gatgcgcctg attttgatca 1015801 aatattaagc cagctaccta cagctgatca gctgcctgac atcgcaacga taaaaagctc 1015861 tcttgaagac gtgaaagcgc aggtggcgca ggtgaaagcc atgccggaag ctacatctaa 1015921 gctttataac ggcgcaaaaa caatccaaga tgcgattgac agattaactg agggagctga 1015981 taagatatac aacggttctc agaagctgac agatggccaa actaaactga cagcgggcat 1016041 cggtgaatat aataagcagt tcgcaaaagc aaaagcgggc tcagagcaat tggtgacagg 1016101 aagcagccaa gtatccggcg gattgtttaa gctgttagac gggtctaaac aggtccaaag 1016161 cggatcatca aaacttgcag acggatctgc atcacttgat acaggtttag gcaagctatt 1016221 ggacggcaca ggagagctgt ctagtaagct gaaggatgcg gctgaccaaa caggagatat 1016281 cgatgctgat gatcaaacat acggcatgtt tgcggatccg gttaaaacca aagatgatgc 1016341 cattcattcc gttcctaact atggaacagg gctgacacct tatatcctgt caatgggctt 1016401 gtatgtcggc ggcatcatgc tgacggttgt cttcccgctg aaggaagcgt caggacgtcc 1016461 gagaaacggt tttgagtggt tcttcagcaa attcaatgtc atgatgcttg taggaatcat 1016521 tcaatcattg attgtggcga cggttcttct attgggaatt ggtcttgagg tagagagcac 1016581 gtggagattt tacgtgttta cgatcattac gagtctcgct ttcctggcga taattcaatt 1016641 tttggctaca acgatgggca acccggggcg atttatcgca gtcattattt tagtgctgca 1016701 gctgggagcg agcggaggaa ccttcccgct ggaattgctt ccgaatttct atcaggtcat 1016761 ccacggcgca ttgccgatga cctacagcat taacggattc agagcagtca tttcaaacgg 1016821 tgactttggc tacatgtggc agatggccgg cgtcttaatc ggcattgccc tcgtcatgat 1016881 tgcactaagc attacttact ttacaatgtt aagccggaag gaagaaacat cagaagaaca 1016941 gccggcttca taaagaaaaa gaacttgttt ccttggaaac aagttctttt tttgttacat 1017001 cccccattta ataagcaatc ctgtataggt taatccgccg ccaaacccga aaagcaaaac 1017061 gatttgatct tttttcagct tcccggcttt cactgcgaga tcgagcgcca aaacaattga 1017121 aaccgaagac gtgtttccgt agtgctcaac actagtgagc gttttttcaa tcgggaacgg 1017181 tgttttttca caaattgact cgatcatgcg caagttggcg ctgtgaggaa caaaccaatc 1017241 gagatcatcg gagctgagtc ctgctttatg taaaagccgt tcaaattcgc cagggacggt 1017301 tcttgcggcc catttatata cctcgcgtcc gttttgcacc atttttccgg aaccgacaag 1017361 ctgcacaccg tttatttcat ttcgcagtcc ggcacgatac aaaatatcgc cgccgttccc 1017421 gcttgttcct tgtacagacg caagaaatcc cggcgtctct tcatctcgtt ctactaacag 1017481 cgcacccgcg gcatcgccga acagtacgca tgtcgttcga tcggtataat cggttacctt 1017541 tgataacgtc tctccggcga tgacgagaat tttttgatga aggccagatg tgatcaatcc 1017601 atttgccaaa tggaggccgt atgtcagccc ggcgcatgtc gcattaatat ccagcgcgcc 1017661 ggtgctttcc cagccgaaat attcctgtac gcggcatgcc gtactcggaa aggcgtaatc 1017721 ggatgtggtt gtggcaacga ggatcatatc gacatcatca agcgttcctt tataacggct 1017781 cttgagattc ttcaccgctt ctatgcataa atcagaggta aattgatgtt catccgcaat 1017841 ccggcgttct ctcattcctg tgcgctgaac gatccattca tcagaggtat caacgatctt 1017901 ttctaaatct gcattggtta aacgtctgct cggcgcatag gtgccgatag ctgtaatttt 1017961 tgcttttgac atatgaatca ctccttatgg tcagattata acactagata ttagtatctg 1018021 gtactaaaaa gaaggttttt ttacaaaaaa agagaagtgt agataggaat ctatgaaaaa 1018081 gaaaaaggag gctgaaaaat ggtcagtcaa gaagcagtag tctttttggc attatccggg 1018141 gctattgcgt ttctgttgcc aatcgggctg attgtatggt ttaagcgaaa gtatggtgcc 1018201 tcgcttaaag tgttttttat tggcgctctc acgttttttg tcttcgctca gctgctggaa 1018261 ggcggcgttc atgtttatgt actgcaagtg aatgaaatga cgaaagaagc gatgcagcat 1018321 ccattatggt atggcattta cggctgcttg atggccggca tttttgagga gtgcggaagg 1018381 tatttgatga tgcgattttt tatgaagcgc catcatactt gggcagatgg tctggctttc 1018441 ggggcaggcc atggcgggct tgaagccatc ctgattacag gcttgtcctc tatctcactt 1018501 attgtatacg catttgcaat caatagcggg acgtttgaac agcttttggt caatggcgac 1018561 gtcaaacagg cgcttttgcc gatacaggag cagctgctgc atactccttc gtatgaatgg 1018621 atgctgggcg gaatagaaag aatcagtgcc attgccgtcc agattggtct gtctctgctt 1018681 gttttgtacg cggttaaaaa ccgccggccg ctgtttttgc tgtattctat tcttttacat 1018741 gcactgttta atgtcccggc ggttttatat caaagaggaa tcatagagca tgctgcagct 1018801 gttgaaatca ttgttgctct tatagcggct ttatcagttt attggattgt aaaagcaaaa 1018861 agggtgtttc aataaaaggt ccaagcagca gcaatgcccg cttggaaaaa tgtgaatgga 1018921 aatattcatt aagcatgggt catcagaata tttctgattc agtctttagc aatgacagca 1018981 agaatgtctg tgttttttac aagagaaaca atggtgtttc tttttcttct tctcgcaagg 1019041 gtcatggcat tctttctttt tcttgcaatg gtcgtggaaa tctttatcga accactcgtc 1019101 aaagaaccaa aaatcatcga accaatcgtg acaacgacat ttctgttcat gtgaatgacg 1019161 acagcacata gaaatccctc ctcttcccat gctctctaca gcatatgaga gattgatagg 1019221 aaaagattgg acgggtccct cgggaaaaga gtatatttta agtagaaaat aaaaggagga 1019281 atgccctatg acgtccgtac gtaaaacgat ggagctcatt aaagaacttg tatcgatccc 1019341 aagcccgaca ggaaatacat atgaggtgat caattatatt gaaagccttt taaaagaatg 1019401 gaaggtagaa acggttcgga accacaaggg cggcttaatt gcaacgcttc caggacgcga 1019461 cacatcccgg catcgcatgc tgacagcgca cgttgacacc ctcggcgcta tggtgaagga 1019521 aattaaagcg gacggccggc tgaaaatcga cttaatcggc gggttccgct acaactcgat 1019581 tgagggggag tattgccaaa ttgaaaccgc ctcgggaaaa atgtacacag gcacaatctt 1019641 aatgcatcaa acgtctgtgc acgtatacaa agacgcggga aaggctgagc ggaatcaaga 1019701 gaatatggag atccgcctag atgaacctgt tcactgccgg aaagatacgg aggagcttgg 1019761 cattggcgtc ggagactttg tgtcgtttga tccacgtgtc gagatcacat caagcggatt 1019821 tattaaatcg cgccatttgg atgacaaagc aagcgtcgcc ttattgctcc gcttaattca 1019881 tgaaattcaa acagaagaca ttgagctgcc gtatacaacc cattttctta tttccaataa 1019941 tgaagaaatc ggttacggcg ggaattcgaa tattcctcct gaaacagttg aatatttggc 1020001 ggttgatatg ggcgctatcg gtgacgggca ggcgacggat gaatattcag tatcaatctg 1020061 tgtgaaggat gcgagcgggc cgtatcatta tcagctcaga aagcatttag ttcaattagc 1020121 cgagaagcat catattgact ataagcttga tatatatccg tactacgggt ctgatgcgtc 1020181 agcagcgatc aaatccgggc atgatattgt gcatggcctc atagggccgg gaattgacgc 1020241 ttcccatgca tttgaacgca cccataaatc atctcttcgc cataccgcta agcttctgta 1020301 ttactatgta cagtcaccaa tggtataagg gggaggacca atgaagattt ataagctgaa 1020361 aagcacattc ggttgggaag gtgatgacgg gttgggagaa cagctgattc agcagatcct 1020421 tgccggagaa aaaagcgcca cgtgcgcgcc gaaatcattg tattcaaaag atgaattgag 1020481 ggacgtttat caaacagcgg gtcagcttgt taccgtttat gataaacatg acaatccaag 1020541 atgcaatata aaagtaacag atgtctttga aaccaccttt ggtgcgcctg atatgaggtt 1020601 agtcaaagga gagggcaatg gagaccgaat tgaggagttt caagaggatc atcggatggc 1020661 atgggcggaa ctgatcaaaa gcggtgaact ggagctgaat gaggatactg ttttgattac 1020721 agagttgttt gtgcttgtta aagattaaaa aagcctgcgg ggcaagaacc ccgcaggctt 1020781 ttcattaacc agaaatggtt gcgttttgtt ctgttttcga ttgggacata acagtttctg 1020841 ctttcgcagg attaaacatg ccttcccatt tagacatcac aacggcagca agcgcgttac 1020901 cagtcaggtt gacaactgta cgtgccatat ccatgatgcg gtctacgccg gcaataaagg 1020961 caagtccttc agccggaacg ccgatggtgc caagcgttgc aagcaagaca acaaaagaag 1021021 taccaggtac ggcagccatc cctttggatg tcaccattaa gacgagcaca agcgtaattt 1021081 ggtgccaaat cgtcaaatca atgccatata cctgtgctaa aaagagtgcg gcaatagatt 1021141 gatagagaac ggaaccgtct aagttaaacg tgtaaccgat cggaatgaca aatgaaacaa 1021201 tgccttttgg acatccgatt ttctccattt tttccatgat acgcggaaga accgtttcag 1021261 agctggacgt actgaacgcc agtaagattt cgtccttcat gtaagcaagg aacttgaaga 1021321 tgctgatgcc ggcaattttt gcgacaatcc cgaaaataac aattaagaag aaagcaagcg 1021381 cgacataaac caatccgacg agctttccga gagagataag agaaccgagt ccgaatttag 1021441 acacagtcac tccgataaga gcgaaaacgc cgaatggcgc cactttcatc acaaggttta 1021501 caacgtggaa catggcatgg gatacacctt caaaaaaggc taatacaggc ttgcctcttt 1021561 caccgatcgc ggaaataccc aatgcaaata gtactgtaaa gcagatgatg gctagaagat 1021621 ccccttcgac caatgactgg aagaagtttg tcggcacaat atggaggaac gtttccgcca 1021681 ctgatttatt actttgttct ttttcagttt caacatattg actgatgtcc gatttttgag 1021741 cttcgtgtat attaactcct gtacccggat ggaagatgtt tgcaagggct agtccgagaa 1021801 taatggcaaa agtcgtgatg atctcgaagt acagaatcgt tctgaagcct aatttaccga 1021861 cttgctttcc atttcctgca ccggctacac cgatgattaa gctggagaca acaataggaa 1021921 tcactatcat tttgattaag cgtaaaaaga gatccccgat tggctgcagg taagtaggca 1021981 atgctgggtt gccataccaa atgacgccaa caatgacacc tagaataagt ccaacgaata 1022041 tttgtgtggc taatccaaac ttaattcttt tcatagatta cctcccaaaa aacaaagtat 1022101 caacatatat catgaataga catatattta atctcactat tagatcaaat tataatagat 1022161 aagaaatcaa ttcgtctata gtaaattata tttcgaaaat aaagaatatt caatgacatt 1022221 atgataatca ccagaattat ctaaaaacag gtgagctttg acctaacctg actattattt 1022281 caaaattaag agatatgtga aaaaataaga aaatcccacg cgtaaggcgc gggattttcg 1022341 ctcattacaa atcgtttact tttatacagt cattgcagat attaccataa cactcatgct 1022401 gctcttctat cttttttccg cattccgcac actttttcga aggcaggttt ctaaaaaatt 1022461 ctgtgatttt ccccagcata accaatccct ctttcccctt tgtagtgatt tcattgtaat 1022521 ataacagatt acaaaaatca ataactgttt tgatacaatg tttaaaacat gcttttttca 1022581 agaaaaatgg gtatattgaa ggaggaccaa tttttttgaa aagataggag gacattatga 1022641 aagttacagt tatcggatgc tatggcggtt ttccggccgc aaatgaagcg acgtcaggct 1022701 atttgtttca gtcaggtgat tactctctgc ttgttgattg cggcagtgcc gtattgtcta 1022761 agctgttcgg atatgtgccg gcggaaaagc tggatgcggt cgttctgtct cattatcacc 1022821 atgaccatat cgctgatatc ggaccgctgc aatttgccaa gcaagtcggt tcgtttctcg 1022881 gcaaaggaga gcatacgctt ccgatttacg gacatgatgc tgatatagaa cagtttcaaa 1022941 agcttacata taaaacacat acaaaaggga tcgcctatca gccggatcag ccgctgactg 1023001 ccggtccgtt tacgatcacc tttttaaaaa cgattcaccc ggtgacgtgc tatgccatgc 1023061 ggattactga cggcagccac actgtcgttt atactgctga ttccagctat caggattcat 1023121 ttataccgtt ttcgaaagat gctgatttat tgatctcaga atgcaatttt tatgccgatc 1023181 aagacggaac aagtgcaggc catatgaaca gcctggaagc tgggcgcatt gcaaaagaag 1023241 ccggagcggg agaactgctg ctgacacatt tgccgcattt tggcgtgcat gacaaccttc 1023301 gcaaagaagc gaaaaccgtt tttaacggag aagtgaatat tgcgaaatca ggttttgtgt 1023361 gggaaggata aaggaggagc accatgttat ttatagacaa tcaaaatatc aatgatccgc 1023421 ggatcaatct tgctatcgag gagtactgtg taaagcattt agaccctgaa cagcaatatt 1023481 tgctctttta tgtgaatcaa ccgtctatta tcattgggaa aaaccaaaat acaatagaag 1023541 aaatcaatac aaaatatgtt gaggaaaacg ggattatcgt cgtccgccgt ttatcaggcg 1023601 ggggcgctgt gtaccatgat ctggggaact tgaacttcag ctttattacc aaggatgacg 1023661 gggacagctt tcataacttt aaaaaattca ctgagccagt gattcaggcg ttacatcagc 1023721 ttggggttga agccgaatta agcggccgga acgacattgt agtagatggc cggaaaatat 1023781 ccggaaacgc tcagtttgca acgaaaggcc gtattttcag ccacggcacc ctcatgtttg 1023841 attcagccat tgatcatgtt gtatcagcat taaaggtgaa aaaggataaa attgaatcaa 1023901 aaggcatcaa atcgatcaga agccgagtgg caaacatcag tgagtttctc gatgataaaa 1023961 tgaccaccga agaattccgc agccatttgc ttcgccatat ttttaacaca aacgacgttg 1024021 gaaacgtgcc ggagtataag ctgacggaaa aagattggga gaccattcat caaatttcga 1024081 aagagcgcta tcagaattgg gattggaact acggccgctc accaaaattt aaccttaatc 1024141 attcgaagcg ttatccggtt ggatcgatcg atttgcacct ggaagtcaag aaaggcaaaa 1024201 tcgaggactg caaaatcttc ggagatttct tcggtgtcgg tgatgtatct gaaattgaaa 1024261 acctgctggt cggaaaacaa tacgaacgca gcgtcatcgc tgatgtgctc gaaggtgtga 1024321 atctcaagca ttactttggg aacattacga aagaggattt ccttgatctg atttactaag 1024381 gcaaaacaca tcgtttgaaa gagcggttgt gtttttgaaa taatggaggc aggagggatt 1024441 cacatgaaag tgtttttaat cggagcgaac ggacaaatcg ggcaaagact cgtctcttta 1024501 ttccaagata atcctgatca ttccatcaga gcgatggtca gaaaagaaga acagaaagcg 1024561 tctcttgaag ctgccggtgc agaagctgtg cttgcgaatc tggagggcag cccggaagaa 1024621 atcgccgctg cggcaaaagg ttgtgacgcg atcattttca cagccggttc cggcggcagc 1024681 acaggctatg ataaaacgct gctggtggat cttgatggag cggcaaaagc cattgaagct 1024741 gcggccattg ccggaatcaa acggtttatt atggtcagcg ccctgcaagc ccataaccgt 1024801 gaaaattgga atgaggcact caagccttat tatgtggcca agcattatgc tgataaaatt 1024861 ctggaagcga gcggtttaac ctatacgatt atccgtccgg gaggccttcg caatgagcct 1024921 ggaacgggaa ctgtttcagc agcgaaggat ctggagcggg gatttatttc ccgtgatgac 1024981 gttgcaaaaa cggtcattgc ctctttagat gagaagaata cggaaaatcg ggcctttgat 1025041 ctgacagaag gagatacgcc gattgccgaa gcattgaaga aactatgaca gtactgacac 1025101 tcagggcttt ttgctcttga gtgttttttt ctgtttctct ataatggaga agaaagcttg 1025161 gcttcaataa tgaatgacta ttcattcact taaggggtgg gagaatgaat cttgtttcaa 1025221 aattggaaga aacagcatct gagaagcccg acagcatcgc atgcaggttt aaagatcaca 1025281 tgatgacgta tcaagagctg aatgaatata ttcagcgatt tgcggacggc cttcaggaag 1025341 ccggtatgga gaaaggggac catttagctt tgctgcttgg caattcgcct gattttatca 1025401 tcgcgttttt tggcgcttta aaagctggga tcgtagttgt tcccatcaat ccgttgtaca 1025461 cgccgacaga aattggttat atgctgacaa atggcgatgt aaaggcaatc gtgggcgtta 1025521 gccagctttt gccgctttat gagagcatgc atgaatcgct gccaaaggtt gagctcgtca 1025581 ttttatgcca gacgggggag gccgagccgg aagctgcgga cccagaggtc aggatgaaaa 1025641 tgacaacgtt tgcaaaaata ttgcggccga catctgccgc taaacaaaac caagaacctg 1025701 tacctgatga taccgcggtt attttatata cgtcaggaac gactggaaaa ccgaaaggcg 1025761 cgatgctgac acatcagaat ttgtacagca atgccaacga tgtcgcaggc tatttgggaa 1025821 tggatgagag ggacaatgtg gtctgcgctc ttcccatgtt tcacgtgttt tgtttaaccg 1025881 tctgtatgaa tgcaccgctg atgagcggcg caactgtatt gattgagcct caattcagtc 1025941 cggcatctgt ttttaagctt gttaagcagc agcaggcgac catttttgcc ggtgtgccta 1026001 caatgtataa ctacttgttt cagcatgaaa acggaaagaa agatgatttt tcttcgatcc 1026061 ggctgtgcat ttcgggaggc gcgtccatgc cagtcgcgtt gctgacggcg tttgaagaaa 1026121 aattcggtgt taccattttg gaaggctacg ggctctcgga agcatcaccc gtcacgtgct 1026181 ttaacccgtt tgacaggggc agaaagccgg gctccatcgg gacaagtatc ttacatgtcg 1026241 aaaacaaggt cgtagatccg ctcggacgcg agctgcccgc tcaccaggtc ggcgaattga 1026301 tcgtgaaagg ccccaatgtg atgaagggct attataaaat gccgatggaa acagagcatg 1026361 cattaaaaga cgggtggctt tatacggggg acttggcaag acgggatgag gacggctatt 1026421 tttacattgt tgaccggaaa aaagacatga tcattgtagg aggatacaat gtgtatccgc 1026481 gggaggtgga ggaggtgctg tacagccatc cggacgtcaa ggaggcggtt gtcatcggcg 1026541 tgccggaccc ccaaagcggg gaagcggtaa agggatatgt ggtgccgaaa cgctctgggg 1026601 taacagagga ggacatcatg cagcactgcg aaaagcatct ggcaaaatac aagcggcctg 1026661 ccgccattac gtttcttgac gatattccga aaaatgcgac ggggaaaatg ctcagacggg 1026721 cactgagaga tattttgccc caataaaatg aaaaagcgaa gcggttagct tcgctttttc 1026781 attttcaatc ctttgcttct tttttaataa tatttagcag cgcctttgta tcatttttgc 1026841 ttaatttgta gtatgtgcca tccttcaaaa aaacggcttg ctggctgccg tcaatccata 1026901 gtctgaatga gtcataccgg tctttatgaa acttgattgt cccttcgtaa tcaggggctg 1026961 atgttttttc tgtcttcacc tgttttccct gattcataat atccagcata tctttgacgt 1027021 gctgtctttt ttcaatctcg atatcttcct ggccgcttga agacagtgtg atcaaatccg 1027081 cgtctaccga ttgatacaca tcgcctgatc ggctgtaaag ataaaaaaat gcgataaaca 1027141 caagaccgat taccacgatg gctgccacta tttttttcat ttgcatcact ccaaacattg 1027201 ttagttttcc cagcgatcgg ggtttccatg cttaaaaggg tggaaaagtg cggaacacag 1027261 cttggttcta agaatttgaa tttatgatta caatagaagt aacgggttga tgtgaggagt 1027321 gaggcgttat gcgcaagtgg attgcggcag caggacttgc ttacgtgctg tacgggctgt 1027381 ttttttattg gtattttttc ctgtcgggtg attccgcaat accggaagcc gtgaaaggga 1027441 cgcaggctga tccggcttct ttcatgaagc cgtctgagtt ggcagtggcc gagcagtatt 1027501 cgaatgtcaa gaatttttta ttttttatcg gggtaccact tgattggttt ctgttttttg 1027561 ttctgcttgt cagcggtgtt tcaaagaaaa tcaagaaatg gatcgaagcg gccgtgcctt 1027621 ttcggttttt gcagaccgtt ggttttgtgt ttgtgctttc gctgattaca acattggtga 1027681 cgctgccttt agattggata ggctatcaag tatcgcttga ctataacatt tccacacaga 1027741 caacggccag ctgggctaag gatcaggtta tcagcttttg gatcagcttt ccaatcttta 1027801 cgctttgcgt tctcgttttt tattggctga tcaaaaggca tgaaaaaaaa tggtggttat 1027861 acgcctggct gttaacagtg ccgttttcgc tgtttctgtt ttttattcag ccggtcatta 1027921 tcgatccttt atacaatgat ttttatccgc tgaaaaacaa agagcttgaa agcaaaattt 1027981 tagagctggc agatgaagcc aatattccgg ctgaccatgt atatgaagtg aacatgtcag 1028041 aaaaaacaaa tgcgctgaat gcctatgtta caggaattgg ggccaataaa cggattgtat 1028101 tgtgggatac gacgctgaac aaacttgacg attcagaaat tctgtttatt atgggccacg 1028161 aaatgggcca ttatgtcatg aagcacgttt acatcggtct ggctggctat ttgctcgtgt 1028221 cgctcgccgg attttatgtc attgataagc tttacaagcg gacggttcgc ctaacccgca 1028281 gcatgtttca tttagaaggg cggcatgatc ttgcggcact tccgctgtta ttgcttttgt 1028341 tttctgtttt gagctttgcg gttacgcctt tttctaatgc tgtctcgcgt tatcaggaga 1028401 ataaggctga ccagtatggg atcgagttga cagagaacag agaagccgct gttaaaacgt 1028461 ttcaggattt ggccgtgacg gggctgagcc aggttgatcc tccggtgctt gtgaagattt 1028521 tcagaggcag ccatccgtcg atcatggaac ggattcaaca tgcggagaaa gaagagaatg 1028581 cgccggaaca tcaggatgct gacaaataaa aagaagcagg tatggaggaa cctgcttctt 1028641 tttactatta ttgtgcagct gcttgtacgt tgattaaccc ttttccatag tagaaagagt 1028701 ttccaagata tgttgcagtg ctttctaaac gatcacggac ttgcgcgttt gtccaagtcg 1028761 ggtgcttaga aagaattaac gctgctgctc cggcaacgtg aggagtcgcc atggacgttc 1028821 cgttataagc gccgtaagtg cctccaggaa gtgtgctttg gatggacacg ccaggagcca 1028881 tcacatcaag ctcagaacct gcgctggaga atgaagctct ttggttgctg ctgtttaccg 1028941 cacctactgc aatagtagaa ggatattttg cagggtagcc gactgtgctt gtgcttccgg 1029001 atgaaccttc gtttccggct gcggcagcaa cgacgatacc gctggaaacg gctttgtcaa 1029061 cgactgtttt cagcgctgta gaaccagtag gtccgccaag gctcatgttg ataacatcca 1029121 tattgttgga aatggcccac tcaatgccgt taataatcca gctatattgg ccgcttcctg 1029181 ttgaatcaag cacttttact gcatataatg atgcgcttgg cgctacgccc agaacaccga 1029241 ttgagttatt aagagcggca atcgtaccgg ctacatgcgt accgtgagaa ctgccgtcct 1029301 ggtatgggtt tgtttcagaa ggtacgaagc ttgctccgcc tctgacgttt aagtcaggat 1029361 gagaagagtc aattccgctg tcgataacag ctacttttac gttagagcct gtgtagcctt 1029421 gagagtgaag agccggcgct ttaatttgag aaatgccata aggaacagat tgcgcatatt 1029481 catgtgcaat atgatcttct tccacatatg caacgctcgg atcttttttc aattctttta 1029541 cagctttttc atccaatgtt gctgcggccg cgttaacata cttaaattgc ttttgaacct 1029601 ttccgccttt ttcagaaata acatcctttt tcttggcgga actcatggca ctcattgtct 1029661 gtttaaatcc gacaatgtat ttcttttctg tactgctttt tccggcagcc tgcgcagaca 1029721 tgttgctgaa cgccatcgta aagattaacg ttaacgcaaa caacaagctg atccacaatt 1029781 ttttgcttct cactctttac cctctccttt taaaaaaatt cagagtagac ttacttaaaa 1029841 gactattctg tgaatttatt gtaatagatg gaataatatt ttagtagacc catttttttg 1029901 agatgatttt atctctattt aggtatatca tctctcgcta tttccgtaga gactcgaaat 1029961 aactattttc atacagaaaa gaacgaaaat agacatgagt aaatgttcat tatgctgaaa 1030021 tgtcatgctt ttttaggtta aatgctcctg agtcccggca aattcctgtc gaaaaaattc 1030081 gttcaaatga cctgcgtgtg cttccgtgag aacaatggat attatcgtga tattttttca 1030141 aagcatgatg ataaaagtat tctgaaaaat aaactttaca gaaaagggat agaatgaaaa 1030201 aattattgag agggaggaag aaataagatg aacattcgcc aagcaaagac atcagatgcg 1030261 gccgccattg cgccgctgtt taaccaatat cgggaatttt atagacaggc atccgatttg 1030321 caaggggcag aggctttttt gaaagctcgt ttggaaaatc acgagtctgt tattttgata 1030381 gcagaagaaa atggagaatt cataggcttt acccagctct atccaacgtt ttcttctgtg 1030441 tcaatgaaaa ggatatacat attaaatgac ttatttgtcg ttcctcatgc gcgtacaaag 1030501 ggagccggcg gccggctgct ttctgccgca aaggattatg cagggcaaaa cggggcaaaa 1030561 tgtttaacac ttcagactga gcaccacaac cggaaggcaa gaagcttgta tgagcaaaac 1030621 ggctatgaag aggataccgg atttgtccat tattgtctca atgtgccggc gaagtgaaaa 1030681 tggcggcttg atgatttggt tttttgaacg ttcttcggtt acgatataaa tgaaaaggag 1030741 tgtgccgaat gtcaacgtta tttcaagcct tgcaggcaga aaaaaatgcc gatgatgttt 1030801 cagtccatgt gaaaaccata tcaacagagg atttgccgaa ggatggtgtc ctgattaaag 1030861 ttgcttattc cggcattaat tacaaagatg gtctggccgg aaaagcagga ggcaatatcg 1030921 tcagagagta tccgcttatt ttaggcattg atgctgcggg tacggtcgtc tcttccaatg 1030981 atccgcgttt tgcggagggg gatgaggtga tcgcgacaag ctatgagctc ggtgtctcac 1031041 gtgatggcgg attaagtgaa tacgcttcgg tgcctggtga ctggctggtg cctttgccac 1031101 agaatctttc gttaaaagaa gcgatggtgt acggaacggc gggatttact gcggcgttat 1031161 cagtgcatcg gcttgaacag aacggtctgt ctccggaaaa aggcagcgtg ctagtcacag 1031221 gagcaaccgg cggtgtcggc ggaattgcgg tatcgatgct gaacaagcgg ggttatgatg 1031281 tggtggcaag taccggaaac cgggaggcgg ctgattattt gaaacagctt ggtgcaagcg 1031341 aagtaatcag cagggaagat gtctatgacg gaacgcttaa ggcgctgtcc aagcagcaat 1031401 ggcagggagc ggttgatcca gtcggcggaa aacagcttgc ctcgctttta agcaaaattc 1031461 aatacggcgg atctgtcgca gtgagcggct taaccggcgg aggagaagtt ccggcaaccg 1031521 tgtatccttt tattcttcgc ggagtaagcc tgctcggaat cgattcagta tattgtccga 1031581 tggacgtcag agccgctgtt tgggagcgca tgtcttctga tctcaagcct gatcagctgc 1031641 tgaccatcgt ggacagggaa gtatcattgg aagaaacgcc gggtgcgtta aaagatattt 1031701 tgcaaaatcg cattcaagga agagtgattg tgaagcttta acaggatcag cttgcagaga 1031761 atgttatttt tctgcaagct tttttgtgga caggatgatc agctgctgaa ctgctgtgtc 1031821 gcgaaacaag attttcctgt aagccgaact ttctcttctc attttaaaaa taattggtga 1031881 taatgattct cattccgtgt tatactactc ttggacatct taaccataga aactaccaac 1031941 aggagagact ggaacatatg aaaaaaacac tgattattct tacagtttta cttctttctg 1032001 tcttaacggc tgcttgctcg tcttcaagcg gcaatcaaaa cagtaaagaa cataaagtgg 1032061 cggtaacaca tgatttaggg aagacaaatg tgcctgagca tccgaagcgg gttgttgttc 1032121 ttgagctagg ttttattgat acactgcttg atctcggcat tacgcctgtc ggggttgccg 1032181 atgacaacaa agcgaagcag ctgatcaaca aggatgtgct gaagaaaatt gacggctaca 1032241 catctgtcgg cactcgctca cagccaagca tggaaaaaat cgcttcatta aaacccgatt 1032301 taattattgc tgacacgacc cggcataaga aggtgtacga tcagctgaaa aaaatagcgc 1032361 cgacgattgc acttaataat ttaaatgctg attatcagga tacaattgac gcttcgctta 1032421 cgattgcaaa agcagtcggc aaggagaagg aaatggagaa aaagctgacg gcgcatgaag 1032481 aaaagcttag cgagacaaag cagaaaatca gcgcgaacag ccagtccgtg cttttgatcg 1032541 gaaatacaaa tgataccatt atggccaggg atgaaaactt ctttacatcg agacttttaa 1032601 cacaggtcgg ctaccgatat gcaatcagta cgtcaggcaa tagcgattca agcaatggcg 1032661 gcgactctgt gaatatgaaa atgacactgg agcagctgct gaaaacagat ccggatgtga 1032721 tcatcctgat gacaggaaaa acagatgacc tcgacgccga cggtaaacgc ccgatcgaaa 1032781 agaatgtcct ttggaaaaaa ctgaaggcag tgaaaaacgg gcatgtatac cacgtggatc 1032841 gtgcggtgtg gtctctgcgc cgcagtgtag acggggcgaa tgccattttg gacgagcttc 1032901 aaaaagagat gccggctgct aagaaataaa agaaaagaca ggcaaacgcc tgtctttttc 1032961 ttatttgata aagccggata agtggctgtt gatattatag tcttttatcc gccatttttc 1033021 ttctgcaaat tcaatgttgc tgaggcaggc gttgacgaga cgggtgcttt gaagctccgg 1033081 gtcaccgccg gatatttctg tcagcagggc gtgaattgcc gcaccgtgcg ccacgatcag 1033141 caccttcttg tttggatacg cctgattcac ttttgccaaa ccgcccatca gcctgtcagt 1033201 gagttcttct aaggtttcca tattcggata gatgttatct ggatagcgct ttgtccgttc 1033261 ctccagcggc atgccctccg cgtcgccgta atcgcgttcc ttaaaatcat ccatctcgac 1033321 tatcggaaga tgcagatatt cattaataat ttccgcggtt cttttcgctc ttttcagcgg 1033381 gctcgtcaca ataatatccc aagaaaagtc ctttacatat tctccggttt ctcttgcttg 1033441 gcgttcacct gttgcgttta gcgggatatc ggttttgcct tggcattttt gctgcaggtt 1033501 ccaatcggtt tctccatgtc ttactaaaca aacggctgtc ataaaatccc cttcctgact 1033561 ttattcatat cgctattata ctaaatcgaa agcgtgtgtc ctatgaaaaa gcctatgcaa 1033621 gaacttcaaa taataaagcc agtccgattc cgccgccgct tccgatggct gcaacagcat 1033681 attgacagtc tggccgtctt ttcgcttcat aaaacaatct ggttaccaga gctgcacctg 1033741 atgcaccgta cggatggcca agagctaagg cgccgccgcg cacattgatt tttgaaaagg 1033801 gaatgccgag ttcttgcgag cagacacaaa ttttgacggc aaaggcttca ttgatttcaa 1033861 ataaatcgat atcatcaggt gttacatcgt gtgtatgtaa gagctgacga atcgcgacaa 1033921 ccggtgccgc gggcggaaag ttggggtgaa tgccgctgac agcgctgccg ataaaccgaa 1033981 gcacaggctt aagtcccagg gctgctgctt tttcttcttc cattaccaaa agagcggctg 1034041 ctccgtctgc tatgccactg ctgttggctg ctgtgactgt tccggagctg gtgtcgaaaa 1034101 ccggctttgc acggggaata atcgcttcta ttggccgcgt tttcaaaaat gcttcgtccg 1034161 tctccaattc cccgagagca acaacttctt cacggtaaaa tccttcatca tgcgcgttcc 1034221 tgctgcgttg atggctgaga agcgcgtact catcctgcat gcttctgctg atggaatagc 1034281 gtgcagccgt atattctgcc gcaatgccca tgtctggatc gccgatcgca tctggagaaa 1034341 agcgagcccg ttctgaaaaa ggggattggc tgctgctttc tgagccgccc gcgatataca 1034401 tcgtgccggc tcccgcttga ataaggctgc aggcatagcg cacagcttca aggccggagc 1034461 cgcactgtct gtcaattgtc attccgggaa ccgataaagg cagtccggct tgaagggctg 1034521 acagtctggc caggttgccg cctctgccag tagcgtttcc gagaatgacc tcgtcaactt 1034581 gatcctctag ctttcggctg agacagcgga tgatgggagc cgccaaatcc tccggcagga 1034641 agggcttcag cagtccgttt tgatttccaa agatcgttcg ttttgcatca acaataaccg 1034701 cattcattta tactgtacac tctcttccag ccattttttc actctggaac gggcaatttt 1034761 tccgctgctc gtttccggca agctgtctgc aaacacccat tttttcggaa ttttatagga 1034821 ggctaatttc tgtttacacc aggctttcag tgttctggca ttagcgtttc caagaatgac 1034881 agctacagcg atttctcccc aatactcgtc gggaatgcca acgacagccg cgctttcaac 1034941 ctctgggcag gcgagaagca cacgttcaat ttcttctggg aaaatattta atcctccgta 1035001 cacgatcatc ccgttttctc ttcctgatat gtatagaaag ccctcttcat caacgtagcc 1035061 catatcatct actgtcatcc attcatctgg tgtgctgccg ttcacatagc cggaaaacct 1035121 catcgggctt ttgacaaata tttttccgat ttctcctggc tggcagcgtt ctcctccagc 1035181 gttgcggatt tcgatccgga cattatgaaa agggcggccc gctgaatgcg gcttccgttt 1035241 gctgtcttcc ggtgaagaaa acgtcacaaa actaagctct gatgtgccgt aaaaatcgta 1035301 cagcttgaga tgaggccatg cagcggcaag cttcttcttg gattctgccg gccagtctgc 1035361 gccggatgaa atgattttga cgggactgtc gggaaaaccc tcaatccttg cgagggcgtc 1035421 tgtcatcgtc ggtacggtat agagaacact gatggattca cggcacagcc attccttcgc 1035481 tttggcagga gaaaactttt tcagcaaaca aacggttcct ccgagaaaca aagtgctgac 1035541 agccccatat aggaagtgag aggacattaa cgctccggga atcagaacct tatcatctga 1035601 tgaaatcgaa aaatctgttt ctgtacaggt aaagctctcc atccatgagc ggtgagatcg 1035661 cgtaaaggcc ttcggttttc ctgtcgagcc cgacgtaaat cccatataaa aagggtgctc 1035721 cggatcaatg gtaggcaagg gatcagcggc tgcctcagaa atatctgcca tacagttatc 1035781 cagcaataca acaggtgtct ggctatctgt cagtttgttt ttgaaaaagg ctaaagtaac 1035841 cacaagatcc gcattgctta tggacagccg ctccttacat tcagccgggc tccagcgtgt 1035901 gtcgatggga atggccgtac atccagccgc tgcggctccg gcaaacagct gtaaaaacgc 1035961 gagactattt gggagcagga tcgccacacg attcggcatg ctcggctgtg accgcagcca 1036021 atttgcggtt tgagagacaa gccgatccca atcatggtac gtgatttgct ccgattcagt 1036081 ctggatcgct acacggccgg gcgatgtttc ggcagtagat gaataggtat gagtaattgt 1036141 catgtattgt catcctcctt ttgtaaacat cgtatcagaa agagacaagg cttgagtgat 1036201 ttttatcgcc agaaatgcag atacagccgc ttttatcaaa tcaccaggca catatgcaag 1036261 gctcatgaag gcggcctgtg acaaatcaat atgcatgata aaagcttgta ccggtatacc 1036321 aagcagataa ataaagatga tgccgaatac gatatgagtg aaaaagagac gcaatactgt 1036381 caccttccgc agcctgttag cggctaaact gatcagccat gaagcgaggg gataagcaat 1036441 caaaaagcct gcgctcggtc cgaaaaacac accaaaaccg cctcgtccgc cgggcaacag 1036501 cggcgctccg aaggcgacga gcagcaaaaa gacaagctgg cttaagaaag cagactttgg 1036561 cctgagaatg ctgcctgcca acatgacacc aagcgtttgc aatgtaatcg gaacgggtgt 1036621 aaaggataag aagagagggg gcataaagcc gagcactgcc atcagcgcgg tgaaaatcgc 1036681 aatatgcatc atgtcgatta atttcagcat gtgaaatcct ccaaaaagta atcaaatatg 1036741 gttatacaat aaatgcaggt aattattatg tcaactgatt tttaatttaa gtttacataa 1036801 tgaacgcaaa aaaaccggcc gtatggcaga ccggtttttg atggttattc ttctgtcagg 1036861 atgacaagcg aatcaacgga agcggccaca tgggaaacgg cgcggctgac ttcctgaagc 1036921 cctccaagaa aggcttgcag atcgacgtcg attttgcctg attgctcttt gctgattttc 1036981 atgctgtgga cgatttcatc gaataagcgg ttaatttgcg tcattttttc tttactttcg 1037041 ctgactagct cattcacgtc tttgatatgc ttggatacaa tgttgatttg tgtattcgta 1037101 ttgttcacaa gctcagaaac agtagagacg gtttttttcg tatcctcaga aagcttccgc 1037161 acttcatttg ccacgacagc aaagcctttg ccgtgttctc cggcgcgggc ggattcaata 1037221 gatgcattga gcgagagaag gtttgtttgt tcagctatgc ctgtgacgat gccgaagatt 1037281 ttttcaattt gctgcgcgat ttcatccagc ttgaccattt ctttttcgat ttggacaagg 1037341 cttgtgtcaa ttttgttcat ctgtttttgc tggacttcta gctctttttt tccgccgatc 1037401 gacttttctt caacagtgct ggatgttaca gtgccggctt tggatgcttg agaaatgcct 1037461 tcagatttgt ccacaagctc ttgaactgat ctgcttgttt ctgaaaacag attggcaatc 1037521 gatccagagg tttcttgaat tttctgatga agaaggtttt tcttttcttc ttgttcatca 1037581 cgggtctggt tgtactcgct ttgaaacgct tcaaggacaa gctgctgttc taagttcaag 1037641 atttttgttg ttgctttaat ggcttttagc agttcttgct gatttgtaat ggacgcttca 1037701 taaatgtcaa tcattgacaa aaggagctct tgaaacgcac ccatatacca ttttggcaaa 1037761 aggccgattc ttaaatggat ggaggcgatt cggttacgct tttcaataaa ttcatcatcg 1037821 ataacgcctg caaacatttc ctgaatatgc cgttttaacg tttgttttaa gcggtcaact 1037881 gagctgtgat cattaatgat atccatcaat gagctttcat ggtcaaggtt tttataaaac 1037941 gcatcgacga tatttacgat attttcttga atgagtggct gaagctgctc taacacataa 1038001 agctcagcat ctcccaacct gaccattttg agctgttttt tgacatctgc atgtttgttt 1038061 gtgagctgaa tgcggttttt ttgttgtccg tttgaatctg aaaagtaagc tgtttcttgt 1038121 tttctgtctt ttttaaataa caatacaatg atcccccttg ggaaaaatat aatttttact 1038181 ttttggcttt ttaagccttt ttctttttta tcggccaagg gaaacatgaa tgaagctgca 1038241 gatgaaaaat atttgaaaaa acgttcatta aaatgaacgg tttaatcgag atctatttgt 1038301 tttaatggtt taatggccgg accctctaca acttcgccag atggcttaaa gcgtgatccg 1038361 tggcacggac aatcccacgt atgctcactg tcgttccact cgacctcgca gcctaaatgg 1038421 gtacaagtcg tatcaacgag atggaggcag cctgtctcat cacgaaatgc tcccgctcgc 1038481 ctgccgttta tggtgacggc tttcccttct cctggcgaaa tgtcttcaaa ttggacatca 1038541 ggcttttcaa gctttccttt tatcaaatgc ttggcgacat ctgcattgta ggaaatcact 1038601 ttctgcaacc cgggattcag atggaaacgg gacggcgtga aaatgctttc gtatgggttt 1038661 tcttttttct ccacaaggtc tgacaataaa gtggctgcga ctgctgagga cgtcatgccc 1038721 cattttttga acccggtcgc tactagaata ttgtcctcat tttccgacat cggcccgata 1038781 aacgggattt tgtcgatcgt cactagatct tgggtggacc aataatatgg aatgctttcg 1038841 atgccgatgg tgctttcggc cagttgtctc agtgtttcat aatgtgtaga catggctttt 1038901 ccctggcctg ttttatggct tactccgctg aagagaatca gcttttcacc gtttacaacc 1038961 gtatagcgga gcgccactga cggctgatcg atactcaaat acatgccctc gggatactcg 1039021 atcttcggct tgatggcaag gacataagat ctgtcggagt acattctcgc agcatataat 1039081 ccgcctccgt cataaaaagg gaagtgggaa cagcatatga taaagcggct cttaatggcg 1039141 tgccggcttt ttgttaccac ttcgggcctt tcgccttttt tgatatcaag cgcaacggtc 1039201 tcttcataaa ttcggccgcc tttttgaaca atttgctcca gaagcgcttt taagtattga 1039261 agcggatgaa attgagcttg attcttcatg acaagcgcca gcttagaacc taagggaatt 1039321 ggaagatcct tgataaggtc tctttcaatt ccgagctttg tgtatgcctc atgctcggtg 1039381 tggatttttt gaacagcgtt ttcatttgcc gtataaagat atgcgtcttg ctcgatccat 1039441 tcacaatcaa tttgatgttc atccacaatg ccttttatgt aatcaattgc gttttggttt 1039501 gcttcataat aaagcctcgc atggtttaat ccgaaatggc ggataaattc gtcgtatatc 1039561 atgtcatgct gtgcggtaac tttagcagtt gtatgcgcag tggttccgtt aagaacctga 1039621 tttgcttcaa tcaaaacgac acggaagcct ctcttcgtaa gttcatatgc cgttgtgatt 1039681 cccgtaatcc cgcctccgat aatggtgacg tcacattcag tgtcctcttg aagcgcagga 1039741 aaagaaggca ggtcagttga tgttttccag tatgtttcag gtgcttcctt tgcaaaatgt 1039801 tgattagcca agccgttata cctccaatca gatttattct taatttttcc atattctatc 1039861 ttttcataca taggaagcag gcattgttca taacataata aggttgaaaa ggagtgattt 1039921 cattggcgaa tcaaaaaaag aaaacattac cgcctcagca ccagaaccag cagcctggtt 1039981 ttgaatatct gatggacccg cgtccggttt ttgataagcc gaagaaagcg aaaaaattag 1040041 agggcaaaac cgctattatt actggaggag acagcgggat tggacgcgct gtctcggtgt 1040101 tattcgcaaa agaaggggct aatgtggtca ttgtgtattt gaatgaacat caggacgccg 1040161 aggaaacaaa gcagtatgta gaaaaggaag gggtaaaatg cctgctgatt gcaggagatg 1040221 tcggggatga agcgttttgc aatgatgtgg tcgggcaggc aagccaagtg tttccatcca 1040281 ttgatatatt ggttaacaat gcagctgagc agcatgtcca gcccagcatt gaaaaaatca 1040341 ccagccacca gctgatcaga accttccaaa caaacatttt ttccatgttt tacttaacaa 1040401 aggcagtgct gcctcattta aaaaaaggga gctctattat taataccgct tcaattaccg 1040461 cctataaagg caataaaacg ctgatcgatt attcagcgac aaaaggcgcg atcgttacgt 1040521 ttacaaggtc cctttcccag tcgcttgttc agcagggcat acgggtcaat gcagtggcac 1040581 cgggtcccat ttggacaccg cttatcccgg ccagctttgc cgcaaaagac gtggaagtgt 1040641 ttggttcaga cgtgccgatg gaacgcccgg ggcagccggt cgaagtggcg ccaagctatc 1040701 tataccttgc cagcgacgat tccacatacg tcacagggca gacgattcac gtcaatggcg 1040761 gaacaattgt gaacggataa taaaaagcca atccttgaag gattggctta ttcgctctgc 1040821 ttgagcgctg catattcttt agagagcgta agaaacgcat ctttatcttt ttcgtccaag 1040881 gctttgttaa tttggtccgt cagcatggca agccgacggt tatacaagga ttcatcgagc 1040941 accatttgaa tgtaaatatc cgtcattgtg acatcgaatt cttttgtttt ttgcgtgttg 1041001 cgggacttca tgagctcagt gtacgatttt ttctctttca taaagaatcc ccccaatgcc 1041061 ttttttatag tatatggata acggtcgaaa aaatcaataa atttttataa tttttagaca 1041121 actaatactt ggcaatctat cgacatatcc tgcaaaatgc cgtaaaccgg caagtcttat 1041181 gaaagtaaaa tcggtttatt actagtcatt tagtaccatt aaatatcatt aaaagatgat 1041241 tttatcttaa atgttaaaaa aacctgtcgt tttacaaaaa cagatgatag attattagta 1041301 taaattttgc agaaaaagga tggaggccat aatatgagtc agaaaacaga cgcaccttta 1041361 gaatcgtatg aagtgaacgg cgcaacaatt gccgtgctgc cagaagaaat agacggcaaa 1041421 atctgttcca aaattattga aaaagattgc gtgttttatg taaacatgaa gccgctgcaa 1041481 attgtcgaca gaagctgccg attttttgga tcaagctatg cgggaagaaa agcaggaact 1041541 tatgaagtga caaaaatttc acacaagccg ccgatcatgg tggacccttc gaaccaaatc 1041601 tttttattcc ctacactttc ttcgacaaga ccccaatgcg gctggatttc ccatgtgcat 1041661 gtaaaagaat tcaaagcgac tgaattcgac gatacggaag tgacgttttc caatgggaaa 1041721 acgatggagc tgccgatctc ttataattcg ttcgagaacc aggtataccg aacagcgtgg 1041781 ctcagaacca aattccaaga cagaatcgac caccgcgtgc cgaaaagaca ggaatttatg 1041841 ctgtacccga aagaagagcg gacgaagatg atttatgatt ttattttgcg tgagctcggg 1041901 gaacggtatt agaaaaatag gaaggagctg accgaacagg gcagctcctt tcataaagct 1041961 atgccgtcgg aattcctccg gtgatgccat atacctgaga tgtcacatag cttgaattct 1042021 ctgaagctag aaatacataa acatcggcca attccactgg ctgcccagcg cgatttaatg 1042081 gagctggcgg cgtgccttgt ccgaatttcg ggatgttttc cgtcggctgt ccgccggaaa 1042141 tttgcagcgg tgtccaaatt ggtccgggcg caactgaatt tactctgatg cctttggaag 1042201 caagctgttt tcccagtccg acggtaaagc cgataatggc gtttttcgtt gctgcgtaat 1042261 ctaacagcat cgggcttgga ttatagcctt caactgaggt agttgtgata attgaagctc 1042321 cctccggcaa atacggaagc gccgctttta caacccagta aagggaaaag acgttcactt 1042381 caaatgtttt atagatttgt tcagtaggca gatcttcgat gttttcgacc gcttgctgtt 1042441 tgcctgcaac gagcgctagc acatcaagtc cgccgagttc gtgatgcgac tgtttgacta 1042501 gatcttggca aaaggattcg tcgctcaagt ctccggggat cagcactgct tttcggcctt 1042561 ctgcttcaat cagctctttt acctcttcag catctggctg ttcctcgggc aagtagttaa 1042621 tagccacatc ggcaccttct ctggcgtaag caattgcggc agcgcggccg ataccggaat 1042681 cgccgcccgt gacaagcgct tttcgacccg ttagtttacc tgatcctttg tagctttttt 1042741 ctccgcaatc agggacaggc ttcatgttct tttgcaggcc tggcggttct tgatattgtt 1042801 cgggaaattc atcatgaaaa aatgctttta taggattcgt aagatttgaa tcagacatca 1042861 gcaacgctcc ttttctgttt ggtgtacatt cgtatgtgta cccctgagca taagcagaaa 1042921 aacatgtttt ggcagtttga atagtgaagg aaaaagaaaa caagaaaaaa caaagccttc 1042981 ttccatattt atcttgtcaa ataagactat atgaattatg ataaattcga gctataaatc 1043041 aactaaatat tgggtgttgg gagagtgaat cgtcatgaaa aaagcggcgg cggttttgct 1043101 gtcactcggt ctcgttttcg gtttttcata cggagctggc catgtggcgg aagccaaaac 1043161 aaaggtgaag gtctataaga actgcaagga gctaaacaaa gtatacaaag gcggagtggc 1043221 ccgcacatcg aaggtgaaaa acaaaggcgg aaaaacgaag tacaagcctt acgtttctaa 1043281 ggcactttac gatgccaata aaaacaaaga ccgcgataaa gatcttatcg cctgtgaacg 1043341 gtaaataaga aaaagcaatc tggtgtccag attgcttttt ttatgcttag gccgcctgat 1043401 cggccgcagc gcttttcgcc ttccttgtca taaggctgac tgccatcatg accgtgatat 1043461 tcaaaagcag ggcgacgatg ccgacattca agtcttttgc ggcttgcggc agagccggaa 1043521 ataaagtgcc gatcgtcgtt tccgtcattg taatataagt aactgctccg acacctgcaa 1043581 taatgccggc gaaagctcct tgctttgtca ccatattatg cttgagcagg ctgaacaaaa 1043641 gggcggggaa tagctgtgtg acaaggctgt agcccatcaa aagcagcgta acgatggtat 1043701 tcccgccttt gaaggtaaaa tacaccgaaa tcagcgcaat caccggcact aaaaacttag 1043761 caagcgccga tacttgctgt tctgtcgtgc ggggcgcgat taccttgtac acattttttg 1043821 caaacagtgt ggaggcggac attaagatca tagaccctgg cacaagtgct gtcagcagtc 1043881 cggcagcacc gataattccg acaaaccaag ggtcaaatgc ttgcagagac agtctcaaaa 1043941 gcgacaaatc cccgtctgcg ccattcagat ctggaacttg caggatagcc gcaaagccga 1044001 cgaaaaggac gaagagcagg accagctggt acaaaggcat gatgatggcg tttttacgaa 1044061 acacttttgg gttttcggct gaatacgaag cggaaaacgt gtgaggccac atgtaaaaac 1044121 caagcgctgt caagagtacg gttgaactga accaggccac actttgtccc gattcgggga 1044181 gcgtaagaaa gccaggcttt gccgtttcaa tctgctgaaa catgtcttga aatccgccgt 1044241 agtaatgaat tggcaaatac acacctaaaa acagaacgac aaccagaatc atgatgtcct 1044301 tcacaaccga tatccaggca gacccgtgaa tgcctgaaac cataacataa accgtgatgg 1044361 aaacagcgcc gatccagatg gcagcggtcg gggtgatttt gccgtacgag gtttccgata 1044421 caatcagccc gaggcctttc agctgcagta caagataggg aatgagtgcg gcgatgccga 1044481 ccagtgaaac gagaatgcca agcagcggac tgttgtattt ttttgtgaaa aaatcagact 1044541 gcgacatcag tttatgctgt ttcgcgtacg tccaaactgc tggaagaagc cagtaagaaa 1044601 ggatgtaggc cagacatccg taggcgatga tataaaaggc tggaccgcct tttccgtagg 1044661 cccagccgct gccgccgaga aacgtaaaag tagtataaat ttcgcctgcc atcaaaagga 1044721 agacgaaaac agttccgaag ccgcgccctc cgaccgtcca ctgctccagg ttcatgtctt 1044781 ttcctttttg ggcgcgtata ccgagaaaaa tactcaagag caggacaccg aagatgatga 1044841 tgagagctgc attcattctg cttcctcctt tttattttcc ttgtcgagga catacacaat 1044901 cgccatcagc gcagaggtca aaagagccca catcacaata taggcaagaa taaacggcat 1044961 gccgaacaca tagggggtca ccttatttgc aaaagggatg ccgagtaaga ttccgataaa 1045021 gggtaaagcg gcaagaacgt gaatcagttt catagaatcc tccttctatt taggattgag 1045081 gtgtacaagc ctaagcgtac tgaaaatgat gtcgcagata tcgcagcaca tgtcattttt 1045141 tggagtgaaa ggctgtggtt cgaattataa ataaatttat tttgtttgta tagtgtgaat 1045201 tgtctgaaat taatgctctg aatcgcccga agagggaacg ggcagtatga ttcaaaaggc 1045261 tcagagtctg tctggggcaa atagatagta tgttaataat tcgctgacct gctcacggat 1045321 tcgcggatta aaatagcgat ggttttcttc ataaccgtcg atgacaaatg tatagagtgt 1045381 aaaggcctca tcgcgttccg tctcgcggat tgcaattttt cttttcctca gttcttttct 1045441 gacctccatc aaatcctttt gtgctatttt taatgattcg ctgataagct gtttataagg 1045501 atgcttcaat tttaatgtgc tttcttcaat tccggcgaga tcacggttaa aaatcgtaat 1045561 ggccatgggc aaaaagagag cccgttcaat taaatcgtat atttcctcct gcagatttgg 1045621 catattgact ccttctttct aagggaacgt ttgttctatt tgtattctat atcggctggt 1045681 gaaatgtttc aagacagaaa aaatcaccaa aactttttag ttttctgctg ataatgtgta 1045741 gaataaggat agacaaaccc ggtaaggagt ataaatgttg gagcattttt tatcctattt 1045801 gacacaagaa catttaactg aattatttca aagctatagg gctttcggtc cgctcattgc 1045861 tgtgctgctg cctttaattg aagcatttct cccgtttttg ccgctgatcg tgtttgtggt 1045921 ggcgaatacg aactcgtttg gcttgtggga aggattcatc ctatcctggg cgggatcaac 1045981 tgctggttcc attctcgtct ttttgattgt ccgtcaatac ggacagagaa aattgcttgg 1046041 atttatccgc agtcatccgt ctgtcagaaa gctgatgtta tgggtggaaa gacacggctt 1046101 cggtcccatg tttcttctgc tttgttttcc atttacaccg tcagccgcgg tgaatgttgt 1046161 tgccggtttg tcaaggatcg gaacgcggcc gtttattttg gcggcagcct cggggaagct 1046221 tgtcatgatt tttatgatca gcttcatcgg atatgatctg cacgcgctga ttacacagcc 1046281 gattcgaacg gtcatcgccg tattggtgat cactgtctta tggtatgtcg gcaaaaaggt 1046341 ggagcggtat ctgcatgtaa gagccagtca gcgtgagcat gatggaggga gacagtaaca 1046401 tgaaaaaacg gttttggttt cttgccggtg tagtgtccgt tgttctcgcc attcaggtta 1046461 aaaatgctgt ctttattgat tacaaggtag aaggcgtcag tatgaacccg accttccagg 1046521 aaggaaacga attgttggtc aataaatttt cgcatcgatt taaaaccatc catcgttttg 1046581 acatcgtcct ttttaaaggc cctgatcata aagtgctgat taaacgggta atcggcttgc 1046641 ccggtgaaac gatcaaatat aaagatgatc agctgtatgt gaacggaaag caggttgctg 1046701 agccattttt gaagcatttg aaatctgttt ctgccggcag ccatgtaacg ggtgattttt 1046761 ctttgaaaga tgtgacggga acaagcaagg tgccgaaagg aaaatatttt gtcgttggag 1046821 ataatcgcat atacagcttc gacagccggc attttggtcc gataagagaa aaaaatattg 1046881 tcggtgtgat ttctgatgcc gaataaaaag acgctaattg aagaggcgtc tttttgtatg 1046941 ccgtttggaa aaatgtgttg aagaaaaatt tgtaaggagc tataatcaaa attgttacct 1047001 gtgtaacaaa atttatatat ttttttgact ggagggccgt ttttattggt ttttgttcgt 1047061 ttttcatgaa acaaaaggag tggtgaatga tgatgaaata tgaagcagtg attataggag 1047121 gagggccggt tggatttatg ctggcttctg agcttgcaat agccggagtg ggaacatgtg 1047181 tgattgaacg gcttgaaaaa cctgttccgc attccaaggc gttgacgctg cacccccgaa 1047241 cgctggagct tcttgagatg agagggattt tagagcggtt cgtatccaag ggaagcaaga 1047301 tacctaccgg acatttttca atgctggata cccgtctgga tttttcaggc ttggatacga 1047361 gctgtcctta cacgcttttg ctcccgcagt ccaaaacaga aaagcttctt gaagatcatg 1047421 cacgaagcct gggaacagag gtgtttcggg gtgccgaggc gctggcggtt acgcaaaacg 1047481 gggaagcggt ccaaacaatt tttaaggatc gggacggcag tgtacggacg atcacaagca 1047541 agtttgccgt tggggcagat ggcgccggga gtaccgtccg gaaacaggcg aaaattgagt 1047601 ttccgggaac agacagcact gtcaccgctg cgcttgggga tgtggtgctc ctttctccgc 1047661 cgccgtcagg tgtgctgtcc ctttgcacaa aagagggcgg tgttatgatt gttccgttat 1047721 ctccagaccg ataccgtgtc gttgtgatca gcccttatcg cacacaaacg ccgaaagatg 1047781 tgcctgtgac tgaggaagag ctgaaagctg acctcctgcg aatttgcgga actgacttcg 1047841 gtttaaccga cccttcgtgg atgtcgcggt ttgggaacgc cgcgcgccaa gcgaaacggt 1047901 atcgggacgg cagaatcttt cttgcgggtg atgccgcgca tattcatttt ccggcgggcg 1047961 ggcaaggact gaatgtcggc cttcaggatg caatgaacct cgggtggaaa ctggcggcgg 1048021 ccatcaaagg ctctgcgcct tcttggcttt tggacagcta ccatgatgag cggcatccgg 1048081 cagcggaagg gctcctcaga aacacggagg cacagacaaa gctgatcgat ttcactcaag 1048141 caggcctcca tttgcgaagc atgatgtcgg agctgctggc cttccctgat gtgaatcgat 1048201 atgtagcggg gcaaatttct gcgctcgatg tcagatatga agctgatcgt accatgccgc 1048261 cgaatcgttt gaacggggca aggctccctg acatgaagct gattctttcc gacggcaatt 1048321 cggaacggct gtacagcttt ctccaaaacg ggacattcgt tttgctgtca ttgaggcagg 1048381 aagctgatga tcatatcgaa gtaaaaggct tacgtacggt aaccgcctcg cttgcagaac 1048441 cgaatgaaaa gttgcggaat gtgcatacca tattgattcg tcccgatgga catgtagcct 1048501 gggcggtgga tgcatcagcg cccgattgtt ccgaggtgat tcaaaaaggg atcagccgct 1048561 ggttttccgt caccagccga gtataattca attcgattgt ttcatctgta acaaaacggt 1048621 atgatagaag aaacaatcga atgaaaaagg atggaaaacc cgatgaacac agatcatacg 1048681 aaacgcaatc tttttgaatt gtatgcggag ctcattcatc agcaggagaa atgggagggg 1048741 cttattaaag cctttttatc tgacgaattg aggaagctgg atgtagagca cgggagtaaa 1048801 tctcaattga cgatgacaga aattcatgtt ctatcctgtg tcggggacaa tgaaccaatt 1048861 aatgtcacgt cgatagcaga aaaaatgaat acgacaaaag cgactgtatc acgcatcagc 1048921 acaaaattgc tcggcgcagg cttccttcac agaacacagc tcagcgataa taaaaaggag 1048981 gtctacttcc gattgacgcc tgctggaaaa aagctgcaca gtttgcacaa atattatcat 1049041 cagaaggctg aacagcgttt tctgtcattt tttgaccgct ataccgagga agagattctt 1049101 tttgcggaac ggctgtttcg ggatctggtg acaaaatggt atccgtcgtc agaagaaatt 1049161 gaaggggggc ttcctagcat ttttaaataa aaaacacgca ctgcggtgcg tgtttttcgc 1049221 tttgcggccg cctcgagaat tctttcattt caccctctgg cagcactcac ttcaaatctg 1049281 atccattaac aacgaaatat ccgcttatat ttcctcatct cgatggtttg cgaattaaaa 1049341 gttcttgaac ccttttttca actaggcact actgccgctg attgagctct ttttgtcttt 1049401 tttttcacca tgaagatggt gaagcaggcg ataaaacggc ggcagcaggg caataaccag 1049461 aatgacgcga atgacctgaa ccgcaacgac aaaggtggaa tcagcatgta aggtaactga 1049521 cgtcgtcgcc atctctgcaa tcccgccggg cgcaaatgcc agaacagaag tgatgagcga 1049581 aattcctgtc agctcggaaa cgatcacggc gctcaaaaac attgctgcga ttaaaccgac 1049641 ggacgagaca aacccgacga tgataatacg ggtgacgccg gcaaacatgc ttttgtacat 1049701 cttagagccg atcgttgccc cgagaaatac ttgtgataca tggttagctt gtgacaacca 1049761 ccatgccgtc atgtcgtgcc ctgtcaccgc agctccgcca acatgtacaa ttgctacacc 1049821 gagcatgctg ccgagcagcc atggagctgg aaattttaaa aatttcgcag ctttgcaagc 1049881 tccccaggca gcgagaataa gaatgacggt ccacaaaacg ggagcgagcc taaaatctgt 1049941 cgttgcagaa gaaatcgtct ctgctgcggc acttgcggta cgatcttgtt ttgtatagat 1050001 cagaatgact aaaaacggaa tggaaagcac cacgagcagc acacgcatca tttgaacgag 1050061 gctgactata gcggtattgg cgcctacttc ctgtgcgatg ctcggcatgg cggaaagtcc 1050121 gccgggagcg gtgccgacaa agctagtcat catatccgtt ttgctgaaac gccaaagcac 1050181 atatcctgac agcatggcca gcaggataga caatatcagc ataacgccga ctgaaaacca 1050241 atggtctttg agaacagaga gaacggataa attcagcttt tggcccaatt cgatgccgag 1050301 gatcatctgc ccgagggcga gccatcgtcg gttaattcct ttttggtctg gtgccatcat 1050361 cagccatgcc ggccgtatca tggcgaggca gcaggcgaca atcagtgttc cgatcatcca 1050421 tccaattgat attccggtta atgaaagaat aaaccccccg gctgcactga ttgcgataaa 1050481 ccatagatct ttgaggagat tttcgtcttt cttcaatgta aaacccttct tcctttttca 1050541 cgtaacactc caattgttca cgtagtgaat gtatttatta ctatagtata tttttgttga 1050601 taaagaaatt atgaattatt ttctataagc gattcacttt tcttatgacc ttgtgttcga 1050661 gcttttctat tgtgtaagtc agagataaac ccgctgtcag cagacacacg gcaagagcgt 1050721 aaaaaatcac ttctccgcca aatgatgtca ggatcagccc gcctgccagc ggtccgattg 1050781 agcgggatat atcccaatgc agaccataga cagcataaaa ccggcccagc aaatgaggcg 1050841 gcgccaattt cgatatgaag gtctggatgt gggttagccc gatgctttca ccaaccgtca 1050901 tcaccgctgc cgtcactaaa agcattgtca gagaggttga gcatgcaaag ccggctgccg 1050961 caagggagta gcaaatataa gtaatgaaga ggatcgtttt cattgaaagc ttttcggtcc 1051021 ctttgacaag aggtacttgg agaacacagc tgaataaagc ttttgctgct gaatagatgg 1051081 tcagcatgga cagataatca gaaaacatgt ttttgctgaa cagcctgtat gttgtttctg 1051141 tttgtgcata taacatgctg atggggagag aaagcagcaa aagaagcagg acaggcctgt 1051201 atattgtaaa gctcgcggac attttcgggg taacagctgg gtgtagcggc tttgtctcag 1051261 gcagtttcag tgcagcgatc agaaagtaga taaacaatgc tgcagcatct aatgcgaata 1051321 tccacacggg gttatgattg tacagcagca tccccactag cggtcctgcc gtcagacccg 1051381 tcgaatagat cgcattgatg accgcaaaca cttccgaacg tctgctttcc ggcgtgcttt 1051441 cagcgatttg ggcgcgggaa gcgggaatgt acaacgatct tccgatgcca ttcatgacat 1051501 agagaatagc gaaaacatac gcatgctcag caaatacaaa ccctgtcatt gccgctgatt 1051561 gaagaagcaa tgcggtcaaa atcgctgtgc gccgcccaag ccgatccgtc acccgtcctg 1051621 cagcgagcgt caggaaaata tcagcaaatg gctgaaggct gatgatcagc attggcatca 1051681 tgatactgcc gtttaattgt tcatgcagat acagcaccat aaaaggtccc atcattgcac 1051741 ctgtcaggct tgtcagcaat tcgccgaaaa agcggagccg aacgggagcg gtatatctcg 1051801 attttataga gtgaaaactg gtcaacatgt gatcgccgcc tttcgctgtt tgatatagta 1051861 gtagtgtata gaaggggcgg cggcccaaaa agtgaagaaa agaagagata aaagttcccc 1051921 ttttgtcggg aggtgcgggg attgaagctg atagagcact acgtggcgct tgtaaaaaca 1051981 ggctgcgccg agtatgggca aatgaacgaa atgacgctca ctgagattgc cgactgttta 1052041 ttttgtacag aaagaaatgc aaagctcatt ttacataagc tggagaacag caattggatt 1052101 atccgggaaa gcggggcggg gcgcggccgc aaatctaaaa tcgcgtttct tcggaggcct 1052161 gaggaactgc ttcttcaaac tgcaaaggaa tataccatgt caggaaagct taaaaaggca 1052221 aaggagctgc ttcagcagta tcagtccgcg tttccagggc ttcaaaacga atataacatg 1052281 tggctatcag aggtattcgg atttgtgacg gagacaggcg agaatggggc gaaggatgtc 1052341 ctgcggctgt tcatcacgcc tgaatctgtc agcagtttgg atccatgcca aatatttttg 1052401 cggtctgagg gccatttcgt caaacagata tttgatacac tcttcacgtt tgattcggat 1052461 atgcaggagc cgaagcctca tttggttcat ggatgggaag aggtcggaaa aaaacaatgg 1052521 agattttttc ttcgaaaagg tgtgttattt cataatggac agccgctgac atcgcgggac 1052581 gttgcgttta catttcagcg ctttttggaa ctggctgaca acccgtataa atggcttctg 1052641 cacggagtga aacaagtctt agaaaagggc ccttattgtg tggagctcat actcgataag 1052701 ccgaatgcgc ttttgccgta tgctctttgt gatgaacggc tgtccatact gccggcagaa 1052761 cagggcggcg ggaaaaatgg aacagggcct tttcagatga atcagcaaca tagcgggatg 1052821 cttgtgcttg aagccaatga gcgctacttc aagggacgcc cctatttgga tcgcgttgag 1052881 tttgtgtttt ctgagcaagc cggagagatg aacggtttta ccattcaaga aaaacaaaca 1052941 tgtcctgagc agcaaactgt ctttgatgag cggcatgttc agtatttgtc gcttaatctg 1053001 aaaaagaagg ggcctcttca gcaccgaagc tttagaaaag cgctccggct gctgatttcc 1053061 tctgaacggc tcgttcgtga agcgggaggg caccgaagaa ttccggttac gtcctttttg 1053121 catccgagtc cttttgagtg ggagggcgtt tcgccatctg aattgttgaa aaaaagcgga 1053181 tacgagggcg aaacaatcgt gctttatacc ttttcggaaa cggatcatcg tgaggacgcc 1053241 gaatggattc aaaatatttg cgcccagcac ggtatcaggc ttacacttca attctgtgat 1053301 gctgctgatc tgcgacggcc ggaaatcgtg cagatggcgg atatcattca tgacagtgcg 1053361 acgttttatc aagacagcga gtttggtttt ctgcatttgc tgctgtcgga gaacagtttc 1053421 ttgtatcagc atctatctga aaagctgaca cagatttgct caggaatgac agagcggatg 1053481 ttttccatgc ctgaccgctg ttcgagaatc aacatcctgc gtgacattga ccggcagatg 1053541 atacaggagc tgaacgcgat cccgctgtat caaaatgtgc tccaggtgac atcaagtaaa 1053601 aatgtaaaag gcctggtgct tgatgaagag ggatggattg atttgtactc cgtatggctg 1053661 tccaaataaa aagagggttc ttttttgaac cctctttttt acgctgccat gctgcggcat 1053721 tgttcagcac aggtgaagca ggctttcgca catgcttggc aatgatcatg atcgtgcttt 1053781 ccgcattcag tgccgcatgc ttcacaaata tcggcgcaaa gtgcacaaat ttctttcata 1053841 aacgggctgt ccgtttgcat ggctttgacc gccagcgcgc aaatatccgc gcattccctg 1053901 tcaagccgga tgcatccgct gagatgatgc tgcacgcttt cttccaagca tttagtgaaa 1053961 caatgattgc aagccttcat gcaatcgatg caagcctcaa tacaagcctc agaatattgc 1054021 tccatggttg attccccctg tatgacagta tatggtttta tgtttcacgg ctgcatttga 1054081 aaaaaacagg ggagtgtgtt tttagctaag gggatatgta catataccct gaatgggtat 1054141 atctaacgtt ccatcagata gtataggaac cagacagcgt gattttgttc atcacgtgct 1054201 gcgcgcgtaa agacgccttt cgcttttaag tttgacgttt cctcggccgc acgcaagtaa 1054261 aagtcgacgg tttcttgttc atctttaaaa gcggcgtcca gtcctcttgt gaaattgtcc 1054321 gggcattctt ccgtttgttt cggcatgatg tgtttgccgg taattgaacc atacagtgtg 1054381 gaaaattcac ggaggtggcg aatctcgtca cgcctgattt cttcaatctg ttttctgacc 1054441 tcatcgctgt gggcgagttc ggcaagcttg cggtagcatt gaatagcact gaattctccg 1054501 ttgatggcct tctgcaaatt ccgaatcaaa acaggatctt cccggtatgg caccggatag 1054561 ggatagtagc tgtaatgcaa ggggattcaa ctccattctt aggaattggg cttctgtaaa 1054621 agtatatgtt gggcagggag agatgtgcgg agataatcag ctttttatat gtgaaaaggc 1054681 cgtttttacc aatagatcag attggtcatt ttcgtcaaca ttcgataaaa tatagagaga 1054741 taaaaagaga ggggtcttct aatttgggag cagagttttt agtaggcagg tccgggagtg 1054801 gaaaaacgaa gctgatcatc aacagcattc aggatgaatt gcgccgggct ccattcggga 1054861 agccgatcat ttttctagtc ccggatcaaa tgacgttttt aatggaatac gagcttgcta 1054921 aaacgccaga tatgggcggg atgatacgcg ctcaagtgtt cagtttttca cgattggcct 1054981 ggcgcgtcct ccagcatacg ggaggaatga gcaggccgtt tctgacgagc accggcgtac 1055041 aaatgctcct gcggaagctc attgaggagc ataaacagga gttcaaagtc tatcaaaaag 1055101 cgagtgacaa aagcgggttt accgcacagg ttgagcggat gctgacagag tttaagcgct 1055161 attgtctgga accggaggat atccgccgga tggcggaaag cggaacggct tccgagtatc 1055221 gcggagaacg tgttttatct gaaaagctcc atgacttatc aattctgtat cagcaaatgg 1055281 aaaaaagcct cgcagatcaa tatcttcact ctgaggatta tttgacattg ctggcagagc 1055341 atatcccgct tgcggaagat ataaaaggcg cccatatcta tgtggatggc ttttatcagt 1055401 ttaccccgca ggaattcagg gtgttggagc agcttatggt tcatgcggag catatcacgt 1055461 tttcgctcac agcggacaag ccgtcatatg agcgggagcc gcatgaactg gaattgttca 1055521 gaatgacggg gaaaacctat taccgcctgc atcagaaggc gaaggaactg aatttggaca 1055581 ttacgtataa agagctgagc gggactgagc ggcatacaaa gacgccggaa ttggcgcatc 1055641 tagaggcaca gtatgaagcg cgtccggcca ttccatacgc agaaaaacaa gaagccctta 1055701 ctgtgatgca ggccgcaaac agacgagctg agctggaagg cattgctcgg gaaattcacg 1055761 ccctagtcag agagaaggga tatcgctata aggatgtagc aattcttgcg cgccagccgg 1055821 aagactacaa ggatatggtg aaggaagttt tcgcagatta cgagattcct tatttcattg 1055881 acggaaaagc atctatgctg aaccatccgt taattgaatt tatccggtcg agccttgatg 1055941 ttctgaaagg gaattggcgt tatgaagcgg tgtttcgctg cgtgaaaacc gaactgctat 1056001 tcccgctcaa tgaaccgaag gccaaagtga gagaacaggt cgatcagctc gaaaattact 1056061 gtatcgccta tggtattaaa ggcgaccgct ggacaaaggg cgatcggttc caatacaggc 1056121 gttttgtgtc attggatgat gattttgcgc agactgatca ggaaatcgaa atggaaaaca 1056181 tgttgaatga cacccgcgat tggattgttc cgccgctttt tcagcttcaa aaacgcatga 1056241 aaaaagcgaa gacggttcaa gagaaggcgg aggcgctcta tcgttattta gaagagacgg 1056301 atgtgccgct gaagctggat caggaaaggc agcgtgctga ggatgacggc agaatcattg 1056361 aagcgcagca gcatcagcag gcgtgggacg cagtcattca gctgcttgag gagtttgttg 1056421 aaatgatggg agatgatgag atttctcttg atttgtttca gcaaatgata gaagccggcg 1056481 cggagtcgct tacattttct ctaattccgc ctgcgcttga ccaggtgttt gtcggcaata 1056541 tggatttgtc cagaatgtat ggcacctcct gcacctttgt gctcggggca aacgacggcg 1056601 ttctgccggc acgccctgat gaaaacgggg tcctgtcgga tgatgaccgg gaatggctga 1056661 aaacgattgg ggttgagcta tcctcaggcg gacgagagcg tttgcttgat gagcacttcc 1056721 tcatctacat ggcgttttca agtccgtctg accggcttta cgtatcgtat ccgattgctg 1056781 atgcggaagg aaaaacgctt ttgccgtcga tgatcgttaa gcggctggaa gaactgtttc 1056841 cgcatcataa ggagcgcctg ttaacaaatg aacctgaaca ggtcagcgat gaggaacagc 1056901 tgatgtatgt tgtgaataaa agcgtggcac agtcctttac cgcgagccag ctcaggttat 1056961 ggactcggga atacgacatc agcgacgtct ggtggagcac gtacaatgtg ctgatgagtg 1057021 agcaggacag gctgcaatcg aaaaagctgt tctcaagcct gtttttccgg aatgaagtga 1057081 agcagcttga acgcagcgtg tcgagacagc tctatggtga acgtattcag ggcagtgtat 1057141 cgagaatgga aacctttaac gcatgcccgt tttcccattt tgcgtcacac gggctgcatt 1057201 tgaaggaacg gcaattcttc aagcttgaag caccggatat cggccagctg tttcattcca 1057261 gcttaaagct gatttcggac aggctgcgtg agcaaaagct ggattggcgc gatttaacga 1057321 aggagcagtg cgagctgttt tcctatgatg cggtagagcg gctggcaccg aaactgcaaa 1057381 aggaaattct gctcagctca aaccggcatt attatgtgaa ggaaaaactg caaaaaattg 1057441 tgacacgtgt gtccggcatt ttaagcgagc atgcgaaagc gagcggattc gtaccgatcg 1057501 ggcttgaact gggctttgga ggaaaagggc cgcttccgcc gctgaccttt caactgaaaa 1057561 acggctgtac gatggaactc gtcgggcgaa ttgaccgtgt tgataaggct gaaagctcaa 1057621 aaggcctgct cctcaggatt gtcgattata aatcaagcga caaaggcctt gacttagcgg 1057681 aagtatatta cggattggca ctgcaaatgc tgacgtacct tgatttatcg attacacatt 1057741 cagctgactg gctcgggatg agggcgacgc ctgccggagt gctgtatttc catattcatg 1057801 acccgatgat tcaatctaat ctcccgcttg ggcttgacga gattgaacag gagatcttta 1057861 agaaatttaa aatgaagggc ttgctcctcg gtgatcagga agtggttcgc ctcatggata 1057921 caacccttca agagggacgt tcaaatatca taaacgccgg cttgaaaaaa gacggctctc 1057981 tcagatcaga ctcagcagca gtcggtgaaa aggaatttga tcttttgaca aagcatgtgc 1058041 gccgcacctt ccaagaagcg ggcgaacaaa tcaccgacgg gcgcgtatcc attgagccgt 1058101 acaaaatgaa gaacaagacg ccgtgcacat actgtgcgtt caaatcagta tgccaatttg 1058161 atgaatcact ggaagaaaac gagtatcgcc cattaaaggc tgaaaaggac aagacaatac 1058221 ttgagtggat aaaaaaggag gcggatggca atgaacattc ctaaaccggc agacagcaca 1058281 tggacagatg accaatggaa tgccattgtt tcaaccggcc aggatattct tgtggcagcg 1058341 gctgcgggct ctggtaaaac cgctgtgctc gttgaacgaa tgattcggaa aatcaccgcg 1058401 gaggaaaacc caatagatgt agaccgtctt ctcgttgtga catttacaaa cgcctcagcg 1058461 gcagagatga agcaccgaat cgcagaagcc ttggaaaaag agcttgtaca gcgccccggc 1058521 tcgctgcata ttagacgcca gctgtctctt ttaaaccggg ccagcatttc gacgctccat 1058581 tccttttgcc tgcaagtgct gaagaaatat tactacttga tcgatcttga tccgggcttt 1058641 cggatagctg atcagacgga aggcgagctg atcggggatg aagtgcttga cgagctgttt 1058701 gaagacgaat acgcaaaggg cgaaaaggcg ttttttgagc ttgttgaccg ctatacgaca 1058761 gaccggcatg atctggatct gcaatttctc gttaaacagg tgtacgagta ttcccgatcc 1058821 catcccaacc cggaggcgtg gctggaaagc tttgttcatt tgtatgatgt atcagaaaag 1058881 agcgccatcg aggagctgcc gttttatcaa tatgtcaaag aagatattgc aatggtgctt 1058941 aacggggcga aggaaaagct cttgcgcgcg cttgagctga cgaaagcgcc gggcggcccg 1059001 gcgccgcgtg ctgacaattt tcttgatgat cttgctcaga ttgatgaact gattcagcat 1059061 caggacgatt tcagtgaact atataagcgg gtgcccgccg tctcttttaa gcgtgccaaa 1059121 gcagtaaaag gggatgagtt cgatccagcg ctccttgatg aggcgacaga tttgaggaac 1059181 ggcgcaaaaa aactgcttga aaagctcaaa accgactact tcacgcgaag tcctgaacag 1059241 cacttgaaaa gcctagccga gatgaagcct gtcattgaaa cgctcgtaca gcttgtcatc 1059301 agctatggaa aacgattcga agctgcgaaa caggaaaaat caatcatcga tttttcggat 1059361 ttggagcatt actgtttagc gattttgaca gctgagaatg acaaaggtga acgtgagccg 1059421 agcgaggctg caaggtttta tcaggaacag tttcatgagg tgctcgttga cgaatatcag 1059481 gataccaacc tcgtgcagga atcgattctg cagctcgtca caagcggtcc ggaggagact 1059541 ggtaacctgt ttatggtagg agatgtcaaa cagtcgattt atcgattcag gcttgcggag 1059601 ccgcttcttt tcctctctaa atacaaacgg tttacagaga gcggagaagg cacggggcgg 1059661 aaaatcgatt taaataaaaa tttccgaagc cgggctgata ttttagacag cacaaacttt 1059721 ttatttaaac agctgatggg cggcaaaatc ggtgaggtcg attatgacga gcaggctgag 1059781 ctgaagcttg gtgcagcgta tccggacaat gacgagacgg aaacagagct gctgctgatc 1059841 gacaacgcag aagatacgga tgcaagcgag gaagcagaag agcttgaaac ggtgcagttt 1059901 gaggcaaaag ccatcgctaa ggaaattcgt aagctgattt catcgccgtt taaggtgtat 1059961 gacggaaaaa agaaaacaca tcgcaatatt caataccgag atatcgtgat tttgctccgt 1060021 tcgatgccgt gggctccgca aatcatggag gagctgagag cacagggcat accggtttac 1060081 gccaatttaa cgtcaggcta ttttgaagcg gtcgaagtcg ccgtcgcgct ttctgtgctg 1060141 aaggtgattg ataatccgta tcaggatata ccgcttgcct ctgtgctgcg ctcaccgatt 1060201 gtcggagcag atgaaaacga gctgtctttg atccggcttg aaaataaaaa agcgccgtac 1060261 tatgaggcga tgaaagacta cctggctgct ggtgaccgga gcgatgagct ttatcaaaag 1060321 ttaaatacgt tttacggaca tctgcaaaaa tggcgcgcgt tttcgaaaaa ccactcagta 1060381 tctgagctga tttgggaagt gtaccgcgac accaaatata tggattatgt cggcggcatg 1060441 ccgggcggaa aacagcgcca ggccaatttg cgtgttcttt atgacagggc gcgtcaatat 1060501 gaatcaacgg catttcgcgg cttgttccgt ttcctgcggt ttatcgaacg catgcaggag 1060561 cggggcgatg atcttggtac ggcgagagcg ctcagcgagc aggaggatgt tgtccgctta 1060621 atgacgatcc acagcagcaa agggctcgaa tttccagtcg tgtttgtagc aggtctcggc 1060681 cggaatttca acatgatgga tttgaacaaa tcgtacctgc tggataagga gctcggattt 1060741 ggcacgaagt atattcatcc gcaattacgc atcagctatc cgacacttcc gctcattgcg 1060801 atgaagaaaa aaatgcgcag ggagctgctg tcagaggaat tgcgtgtgct ctatgttgca 1060861 ttaacgagag cgaaggaaaa gctgtttctg attggctcat gtaaggatca tcagaaacag 1060921 cttgcaaaat ggcaggcatc cgcgtcccaa actgattggc ttctgccgga atttgaccgc 1060981 tatcaggcga gaacgtatct agatttcatt gggccggctc ttgccaggca cagagacttg 1061041 ggggatttgg ctggtgtgcc agcacacgct gacatctcag gtcacccggc tcgttttgcc 1061101 gttcaaatga tccattccta tgatttgctt gatgatgatc tggaagaaag aatggaagaa 1061161 aaaagcgagc gcctagaagc gatccgccga ggtgaaccag ttcccggctc gtttgcgttt 1061221 gatgaaaaag cccgcgagca gctgagctgg acctacccgc atcaagaagt gacgcaaatt 1061281 cggacaaagc aatcagtttc tgagatcaag agaaaaagag agtacgagga tgaatacagc 1061341 ggcagggccc ctgtaaaacc ggctgatgga agcattctgt acagacgtcc cgcttttatg 1061401 atgaaaaaag gcctgacagc ggcagagaaa gggactgcca tgcatacggt tatgcagcat 1061461 atcccgctgt cacatgtgcc gtcgatagaa gaagctgagc agacggttca caggctttat 1061521 gaaaaagagc ttctcactga agaacaaaaa gacgctattg atatagaaga aatcgtgcaa 1061581 tttttccata cagaaatcgg cggacagctg atcggtgcta agtggaagga ccgggaaata 1061641 ccattcagct tagcgcttcc ggccaaggag atctatcctg atgcacacga ggcagatgag 1061701 ccgcttttag tgcagggtat tattgactgt ctctatgaaa ctgaggacgg attatatcta 1061761 ttggattata agtcggaccg gattgagggc aaattccagc atggatttga aggagcggcc 1061821 ccgatcttga agaaacgata tgaaacgcaa attcagctgt acacgaaggc agtggagcaa 1061881 attgcaaaaa caaaggtaaa gggatgtgcg ctttatttct ttgacggagg gcacattctg 1061941 acattatagc gagatccata agctccggaa tttcaggcgg agcgggtctc gttttctata 1062001 taaaagagag gtgaaagcat ttgcggattt tacatacggc tgactggcat cttggaaaaa 1062061 cgcttgaagg aagaagcagg ctgagtgaac aggccgatgt gctggatgaa ctgaatacga 1062121 ttgtaaagga tgagcagatc gatgccattg taatggcggg ggatgcattt gacaccgtaa 1062181 acccgccagc tttagccgag cagctgtttt atgaaagcct gtctgcgctt agcgacagag 1062241 gaaagcgccc gatcgtcgtc attgccggaa atcacgataa tcctgaccgt ttgtccgccg 1062301 cttcaccgct gacacatgaa aacggcattc atttaatcgg ttatccgaca acagagccga 1062361 ttcatattga agtgccttca gcaggagagc ttttggcggt tggagcgctg gcgtacccat 1062421 ctgaagcgcg gttaaatgaa gtgctatccg atacgtttga tgaaaagctg ctccgtgatc 1062481 actatgatgt gaaaatcagg caggcgtttg agcatatgac aagccggttc cggaccgatg 1062541 cagtgaagat tgccgccagc catatttatg tggcaggcgg aaaccaaacc gattcagagc 1062601 ggccgattga agtcggcggt gcatacacgg tggctgctga aagcctgccg gcagatgccg 1062661 cttacgttgc gctcggccat ttgcatcgcc cgcaaacgat caagcgggcg cggacgcttg 1062721 cgcgttattc aggatctccg ctcgcctaca gcttttctga agcgggctac gctaaatcag 1062781 tgacgattgt ggacgcaaag cctggggaag aggccacttg gcaagaggtg ttattatcaa 1062841 gcggcaagcc acttgtgaag tggaaagcgg caaatggatt aagtgaggtg tacagctggc 1062901 tggatgaagg cagagatcag aatgcttgga ttgacttgga aatccgtgtc gcggaccagc 1062961 tgtcacttga agagattcac aggctgcgga aggcgcaccc gggctttatc catatcaggc 1063021 cggtttttga agaacagaac aaagaccggg aacggatcga ggttaaacat gtctcaatcg 1063081 aggaccgctt taagaaattt tatgaaaaac aaactggcgg tgcggtgccg gatgaagaaa 1063141 tggtgaagct gtttttagag cttgcatcag gcgttgaaga ggaggatgcg aaatgaagcc 1063201 gatcgcctta agcattaagg ggctccacag ctttagagag gagcagacga tagattttga 1063261 aggcctttcc ggtgccggtg ttttcggcat tttcggcccg acaggaagcg gtaaatcctc 1063321 tatactcgac gcaatgacgc ttgctttata cggaaaggtg gaacgggcgg cgaataatac 1063381 gcacggaatc ttaaatcacg ccgaagatac gctgtctgtg tcctttacct ttgcgcttca 1063441 gacgaatcac caaatctcat acaaagtcga gcgtgtgttt aagagaacgg atgaaatgaa 1063501 ggtaaaaacg gcactttgcc gcttcatcga aatcaaggac gagcatacgg tgctggctga 1063561 taaagccagc gaagtgaata aaagagtgga ggagctctta gggctgacga tcgacgattt 1063621 tacgagagcg gtggtgctgc cccaagggaa atttgctgaa tttctgtctt taaaaggggc 1063681 agagcgcagg catatgcttc agcgtttatt taatttggag caatatggag acaggcttgt 1063741 gaaaaagctg agacggcagg cgcaggaagc caatgcgaga aaaaatgaaa tgcttgctga 1063801 acagtccggt ctcggtgagg cgagctcaga ggcagtggag caggctgaaa aggttctcga 1063861 acaagctgaa gcccggctgg aagcgatgag gaagaaccgt gatcaggcga aggagcggtt 1063921 tacagagcat caggagatat ggaatgtcca aaaggaaaaa tccacttatg aagaagagga 1063981 aaaacgtctc gcagaagaac agccgcatat agacagcatg caaaaacgcc tgctggaagc 1064041 agaaacagca gcagccctta agccctatgc ggaccggtac gcagaagcga tccagcatga 1064101 ggagcaagct gaaaaggaac aaacgctagc ccaaaaggat ttagcagacc ggacagcttt 1064161 ctttcagcaa aaacatgaag agtatgaagc gtggcgccag cataaaagcg agaaagagcc 1064221 tgagctttta gccaaacagg aacagctttc acgcttgcag gaaatcgaaa tcaaactgag 1064281 tgaggccaag caagaggaag agcgcaaaaa ggctgacctc cggcagaaag aagaggctct 1064341 tcaatctgtc atgaatgaat tagagaccgt aacagaccgc ctgacacgag ggcaaaacag 1064401 acagacagaa ttgaagcagc agctcaaatc cctgcaggtg acatccgatg agcgaaaaag 1064461 ctgccagcag gccgcagaga tggcattgcg catcagacaa accgaggaac aaatcaaaaa 1064521 agagaaaaaa cgaagtgaag aattgaacct cgtgctgcag aagatgaatg aagagaagaa 1064581 tacactcgtt caaaagacgg aagcggaaga aaacaacatc attcaggcat atgaggcagt 1064641 tcaaactgtg taccatttgg tgtgcgaaac ggaacgctca ttaacacgta tgacggaaga 1064701 ggctagaaag agtcaacaca cgcttcactt acagcgtgaa aaagcaaggg tggcactgct 1064761 gacaaaagag ttagcccaaa agctgactgc cggaaagcct tgcccggtat gcggttcaac 1064821 cgatcatgat ccatctgcct cggtacatga aacgtatgaa gccgacagcc atcttgaaga 1064881 ggacatcaaa cggacagatg tgttattgac ggaagctgca gctctcagcc aggagattct 1064941 ttcagccaaa attatgcttg aagaacagtc cgcgcgcttt attgaacagt gtccgttttt 1065001 gcagacaatt caagcacaga accttgaagc ggcagcttcc ttcgaacatc agccggtgta 1065061 tgaagcattt gaaactgcca aatttgaatg gaaacgaatc aagcaggaca ttctttctgt 1065121 taagacacga atggcacaaa tgattggcgc ctatcaggag tctttaaaaa aggccgagca 1065181 gcttaatgaa aaaatcggtt ttgaaaaaag agaagccgac cgtattgaaa gcatcatcag 1065241 tgagcttcaa tcctcaatgg acagcagtct gaacatgttt aaagaagcat ttcagaatca 1065301 atctgtggac gaagcagaaa aatggcagca agccattgaa gaaaaggacc gggctgcaga 1065361 agaatgtgaa aaacgaattg agaagagtat cgcgtttctt gctgagcatg aagcacaaaa 1065421 ggaaaaactg cgggaatcgg gacaccggct tgagcgggaa aagctggagc ttcattatgc 1065481 ggctgaacgc atcaagagcg tgatagctga ttatgagcac gaactcggag attatgcaaa 1065541 aggagattcg attcaaatca aactccgctc tgtccagcag gatctaaagc tgttaaagga 1065601 aaaagaacaa tctttatatg aagaactgca aagcgcccaa atgaagctca accaagcgaa 1065661 aagccgcgct tctgcaagcg agctcactct tcaagaggcg aagggcagat tggaaaaagc 1065721 aaaagctgct tggcttgagc atacaaaaaa cacctccatt acccggactg aggaggttga 1065781 acaaagtctc atcccagctg atgaacttga aaagatgaaa accggcatag accagtttat 1065841 ggataaactg aagcaaaatg ctgcaaactt aaaacgagta gcagagatac ttgccggcag 1065901 agcattatca gagagcgaat ggaacgaaac cgttgcagca ttacaagaag ctgaggacgc 1065961 atttggcgct gctatagagg aaaaaggcgc ggccgcaaaa gcactggctg tcattcgcga 1066021 ccatcataaa cggtttaatg aaattgaagc tgaactgaaa aaatggcaga tgcatatcga 1066081 caggctggac aagctgcaag ctgtgtttaa aggcaatacc ttcgtcgaat ttttagctga 1066141 ggagcagctt gaaagcgttg cgagggacgc ctcagcaaga ctcagtatgc tgacaagaca 1066201 gcgctatgcc atcgaagtag attctgaggg cggcttcgtg atgcgggatg acgcgaatgg 1066261 aggcgtacga cgcccggttt ccagtttgtc tggaggagag accttcctca cctcgctttc 1066321 acttgctctt gcgctgtctg cgcagattca gcttcggggg gaatacccgc tgcagttctt 1066381 tttcttagat gaaggcttcg gcacactgga tcaagatctg cttgatacgg ttgtaacggc 1066441 cttggaaaaa cttcagtcag acaacctggc tgtcggtgtc atcagccatg tgcaggaact 1066501 gcgtgcacgg cttccgaaaa agctgatcgt ccatccggct gaaccgagcg gccgcggtac 1066561 gcgggtatca cttgagttga tgtaagggag gagcggatat ggcaaagcag attgccggaa 1066621 tatgtgagct gtgcggccgg agcgatgtcc agctgacaga gcatcatctt acaccgaaag 1066681 aggaaggcgg aacgtttttg ccgacagcga tgctctgtat tccttgtcat aaacagattc 1066741 atgccttata taccaatcaa gagctcgctg tacgtttaaa tggaatggct gaactcagaa 1066801 gcgatccaga gcttgcccgg tttgtcaaat ggatcagaaa acagccgcct gagaagctga 1066861 tcaaaactaa gaaatcaaat gaacgaaaaa agaaaaaatg actaaaaagc agccctctct 1066921 ttgcagagcg gctgctttta tccgtttcca accatatcct gatcgttgac atcggggtct 1066981 atataatttg tcgcgttgac tgcattattt aatagaagga aatctcccgt gtttcctgct 1067041 cccgaaccga gcgcagattt tgaagagctt ttcggagaaa ggtaaaagga atcaccaaag 1067101 tttacgactc cgcccgatat ggaattgata gctataggcc cgacaattgc tggcataaac 1067161 gacacccttt atcgaagtct ctgtttatta tatgttcttg gcgggcgatt gtgagcgcgg 1067221 agactgaatc tgtctgatat gtttgagtct cgcatcaccg cgaataagcg aagctgatcc 1067281 ggcatgtaaa acagaagagg ctgagacccc ttgaattttg atgctgcgaa cataaatagc 1067341 cggcacctcg tggcaaaacg cgctttgtac acctgtttcg gggagcggct tcacggcctg 1067401 ctgctgaaag atctgatact cctttttgtt aaatgagcct tcattatggt aaaacgtgga 1067461 cagagaacgc tgcacagcaa atacttttac actcatatcg atttcatttg tgtcgccaac 1067521 ttgaaacaca cttgcgatcc cgagagaatt aaacttaact agtctgatgc gcgatatgcg 1067581 tttaagcatt attctggcgc aagcggagca aacggcccaa taataagaga ttcaggcggt 1067641 gtatcaaaaa tagaagacag gtagatggat tcagtgtctc cgatgtggaa aacggaggaa 1067701 ctggacacac cgttcatccg aatatccccg acttccaagc tgcggttgat gactgtaaag 1067761 atcatgcttg ctcatctcct ttcatttctg atggaatatg ctccagaaag tgttctacag 1067821 cgcggatgac atcacgcttc acatgctcag cgatatgttc tgcatattgt gcaggcggtg 1067881 tattttcttc ttttttgata tgggacatat aatagtgaat cctgctgtcc atttgttttc 1067941 tgatgtcttc aataacatga tgtctgtttg tatcgtcaag tctgctgtca tattgatttt 1068001 caagctgttc caaaatatct gggatttcct cggttaagta catgtcgaca ttctggcgga 1068061 tctgctgcat gagctgagcg ctctcttcct gctgcatcat cccgatttgc ggtgtcgact 1068121 ggctgacgtc aaagttttgg acgctgttcg ggtcagtcgg atttaaaccg atattcaaag 1068181 tcccgtcgag cctttcgatt ttcagctgat caaatttata ctccacacgc tcaatggtag 1068241 tggccggccg ctgtttcatc gtattcattt cagtttgaat ctctttcagc tgacgttcga 1068301 gctgctgaat gtgaatcgcc tgctgctgaa cgaaggaatt caagttttgc aggtaagagg 1068361 aaacagattg atcatacatg ttcttcacct ctttcatatg attaacggcc aggaggctgg 1068421 agcgggacca atgaacctgt gtcgggctcc tgcagctgga gcggttgccc tgagccagaa 1068481 acttctggtg ccggctctac atagcttcct gtattataca aatttgacag tgacttgatt 1068541 gatccggcgc tcccgatttg cagaatggag gagttgctga ttgattccag ccggagatag 1068601 ttgatttgaa tggtttgatt aatatagaag ttcatgagcc tcactccttt tacgcattgg 1068661 ccacgatcgg ctgatcaacc gcatcattgt catacacatt cgtcgcgttt tgataattca 1068721 tcaccttgag gctgtcgccg gtattaaagc tgccagcacc ggcaaacgtt ctgacctgag 1068781 cctgaggaga aatcgtaatg cagtccccga tgtgaacgac tccgctcgta ccaatcgcat 1068841 taattttaaa cgctccgaca atggccggca tacgagcaca tcctttgttg aaaaattaaa 1068901 aaaagacagg taaagtgaaa tgacaattcc gatttcaatt gggctattca cgatagctta 1068961 tgacaaacgc acatatgtgt gagagaaatt ttaaggggac atatcggctc tttgtgaaag 1069021 cgttttattt tttcgggccg ttatgtttaa acatggcaaa agaggatgtt gggtataaat 1069081 tgagcggaaa tgcggcgaag gatgccgcta tccgcctatg gtgatttttg tttatttctt 1069141 tggtgttttt gcgtgtagaa tgctttttgg agtatgtcgt gctgcggtat tcgatttttg 1069201 ggcgggcaca ttctcgccct gaggtatatc tcagaagtgc tgagcaaaaa tcggagttaa 1069261 atgtggtgta ttctaattgt tatagaaaat gatttacata cgggagtttt caagatatct 1069321 cccaaaaatc atttcttctt taatccgggt attcagcagg atatccagct cttggctgca 1069381 ttgaatcgtt tcttttgaat tcatgccgta tttttgtgcg gtttcaatta gtgtgatcct 1069441 catttcttca attttactgt tcattacgct atctccaatt ctagatttta ttttgatata 1069501 aatacaggat atcgttagta taacctattt tggctcaaaa ggttgccttt cgtcaatttg 1069561 actaaaaaag cgacaatttt tgctgcggcc ttttttaatg gagaaaggac taaagtcttg 1069621 ctaagtgtgc ttgcaaaaag tcctgccgtt cctcaatttc tctaagtatg ttggtctgct 1069681 ccttttcgat ttgaaagggg ctttttttga taaaaggatc atcagcagca ctttgacaaa 1069741 tgtcaaggtg ccattcgttg atgagaggag ataatcgttc aatagtaaac gaccgcttca 1069801 gcacgttttt cattaaggtg tgatattgcg acctgaaggc gggaatggat agaagccttg 1069861 acgaaagcgt ctttcctttt gtcagaagcg ggtcttcttc ataccattct tgtacggcaa 1069921 gcgatcttgt ctccatcggg gaaacgtaaa gccgaccgga ttcgtttaaa caaaatgtgt 1069981 agtaaaagcc ttgattggtg caggtgttgc cgatcagcca caaaaaaaac agcttgacat 1070041 ccagatacaa tttaatcctt tcagccaatt cgtcatctcc ggctgtgcgg atcagtatga 1070101 aaaattcatg taagaatgcc gaggaatcat tgttaaaaag ggacaatgga acccttggat 1070161 cggccgtctt cactccgtaa ctccttttac cggctggctg atggttcttg atgttcaaat 1070221 aaatgccttc aggctggcca ttgatggtca gaaagctgta cgaggcaacg ggagcaggta 1070281 cgccgatctg gtcaaaaaaa caataggcga gtctgcgccg catcagggac ggatcatcct 1070341 gttctgcatt caaaaaaagt gtcctttcac caagcagaga cttttcccag ctgatttcat 1070401 aggatgcctt ttccgctctg tcacgctgtg tgagaagaat gggagaaaca gatcgatctg 1070461 ttacgaaaag ccccttggct gtacctttcc ttttcagctg ctcccgatga aaaaataaat 1070521 gcacgcgctc catattcttt cctccttctc aaaacgacat ttgtatgata tgtagagcaa 1070581 gcccgtcctg aaacgaaatg aaaacggaat tgagaaaaag ggatttcagc attcgacaga 1070641 gaatacatga aggagcattc tgatttaaaa gatgatggag gaataacatg aaatttgcga 1070701 caggggaact ttacaaccga atgtttgtcg gcctgatcat tgacgatgag aaaattatgg 1070761 atttgcagaa ggctgaaaaa aaactgtttg aacttgagac gattccggga tcgctgattg 1070821 aatgtatcgc agaaggggat aaattcgttg cgcatgcaag gcagctggcc gagtgggcaa 1070881 agaaaccgaa tgatgagctg ggatcattta tgtattcatt atctgaggtg aagctccatg 1070941 cacccattcc gaagccatca aaaaatatca tctgcatcgg caaaaactac cgggatcacg 1071001 cgattgaaat ggggagcgag gctgatattc cggagcatcc gatggtattt acaaaatcgc 1071061 cggtaacggt tacggggcat ggtgatatcg taaagagcca tgaagaggtt acctctcagc 1071121 ttgattatga gggagaactt gctgtcgtga tcggaaaaag cgggactcgc atttcaaaag 1071181 aagatgcata tgaccatgtt ttcggatata cgattgtgaa tgatatcacg gcgcgtgatc 1071241 tgcaaaaaag gcataagcag ttttttatcg gaaaaagctt ggatacgaca tgtccgatgg 1071301 ggcccgtgct tgtacataaa tcatctattc aggagccaga gcgcctcaag gttgaaacaa 1071361 gagtcaacgg cgagctgcgc caatccggtt cggcaagcga tatgatcttt tccattccgg 1071421 aattaattga aaccctctca aaggggatga cgcttgaagc gggcgacatt attgccaccg 1071481 gtacgccgtc tggtgtcggc aaggggttta cgcctccaaa attcttgcgg tcaggtgaca 1071541 aaattgatat tacaattgat ccgatcggaa cgctgtcaaa ccaaattggc tgaataaaac 1071601 tggagggcgg acccggaccc gcccgttttt tctgataatc atctttgtga cagaggacaa 1071661 gttcatggta ctataagtgg ggtaatttat ctgatagggg gaacatatat gacacaccta 1071721 catattacga catgggtggt agcgctgatt ctgcttttcg tcagctactc gctgtattcg 1071781 tcaggaagtg caaagggcgc aaaaatcact catatgattc tgcggttatt ctatatcctt 1071841 attattttga caggagctga gctgtttgtc cgtttcgcca actggaacgg agaatacgcc 1071901 ggcaaaatga ttctgggcat tatcaccatc ggcctgatgg aaatgctcct catccgcaag 1071961 aaaaaagaaa aatcaacagg aggcctgtgg gtcggcttcg tcattgtcct tttgctgaca 1072021 gtgctgctcg gtctgcattt gccaattggt tttcaattgt tttaatagaa aaacctatga 1072081 acccggctct ttgatagagc tggttttttt tatatttatc ccctcatatt ccaaatcatt 1072141 taaaataacc ttaaaattcc ctgtaagcgg tatctcgtcc tatgaaatta tgataccttc 1072201 aaggagattc attattttgc aggagggata acatgaaacg cagaaaattc agctcggttg 1072261 tggcggcagt gcttattttt gcactgattt tcagcctttt ttctccggga accaaagctg 1072321 cagcggccgg cgcgatcgat caggcggctg ctctggaaaa cggcaaagag cagacaggcg 1072381 ccatgaagga gccggaacag gtgaaatggt acaaagtgac cccgggagca acggatattc 1072441 agaaaaactc acatatggca ctgaccgtaa agagtgattc agtactgaat gtatctgtat 1072501 atccaagtaa ggaaaaagcg cttaaagatg agacgtttga gatgtaccgt tctttcacag 1072561 cggaggatgg aaaaagcgaa gtcatttttc catacgcgtg gagcggccct tactatgtaa 1072621 aagttgaata cctcggagaa gaagaaccag aggacggcgg aacggcagaa gcagctgcag 1072681 aagccaagta tacgattggg tataaaggca ccaaaaaaca gccgtcagat ttagaagagg 1072741 aagaagcttg tccggttgaa atgagtgtcg atcagaagaa atcaggaaaa ggcatcctgg 1072801 ataagttgag atcgattcgt gatgagcagc tgagccaaac agcagaaggc aaagaactga 1072861 caagccttta ttacaaagca gcaccgttta tcgttgcaaa gctcgcactc aataaaacag 1072921 caagaaatga aatctatcag gatcttgtga cattaaagcc gttatttgac gatgtgtcag 1072981 aaaacggagc atcatcttcg tataaggtca ctgaaaagga tcaaaaagcg atcaaccggc 1073041 tatatgataa agctttacaa tcagtcccgt cattccttaa agaggagata aagaaacaag 1073101 cggaccgact aaatatgaag cagctgcaag gcaaaacagc aggagccatt ttaacagaaa 1073161 acaatattgc agcaaaaagt gaagttcaga caacaaaggt tattttcaag gtgaaggaca 1073221 ataaaagcct ctcatccgta cataatgaaa tgaagggctt ttctgcaagc gcgcaatcga 1073281 aaaaagacat atctaatgtg aaaaaggcaa agaaactgtt tgacaatctg tattcatttg 1073341 aacttccgaa agacgagaaa cagaacggcg catatacggc aagcgccaaa agggtcaaaa 1073401 gcgctgctgc gacactatcc aagatgtcca atgtagagtt tgcggaaccc gtacaggaat 1073461 acaaaagctt ggcaaacgat attcagtacc cttatcaatg gccgcttaaa aacaacggtg 1073521 aaaacggcgg tgtcaaaaat gcggatgtga aatatgagcc tgccaacaca ttgctgtcca 1073581 aacgcaagct taacgataca ctcattgcag tagtagacac aggcgtagac agcacgcttg 1073641 ccgatttaaa aggaaaagta agaacagatc tcggacacaa ttttgtcgga cgaaataaca 1073701 atgcaatgga tgatcagggg catgggacgc atgtcgcagg cattattgca gcccaaagcg 1073761 ataacggcta ttcaatgact ggattgaatg ccaaagcaaa aatcatccct gtaaaagtgc 1073821 ttgattccgc aggttccgga gatactgaac aaattgctct cggcatcaaa tatgctgctg 1073881 acaaaggagc aaaggtgatt aatttaagtt taggcggagg ctacagccgc gtgcttgaat 1073941 ttgctttgaa gtacgcagct gacaaaaatg tcttgattgc cgcagccagc gggaatgatg 1074001 gagaaaatgc cttatcttat cctgcatctt ctaaatatgt gatgtcagtc ggcgcaacga 1074061 atcgcatgga tatgaccgct gatttctcta actatggaaa aggtctggac atctctgctc 1074121 cagggtctga tatcccgagc ttagtgccga acggaaatgt cacgtacatg agcggaacgt 1074181 ctatggcgac gccatatgct gccgccgctg cgggactgct gtttgctcaa aatcctaagc 1074241 taaaaagaac agaagttgag gatatgttga aaaagacggc agatgatatt tcctttgaaa 1074301 gtgtcgatgg cggagaagaa gagttgtatg acgattatgg cgatccgatt gaaattccga 1074361 agacacctgg tgtagactgg cattcaggct acgggcggct gaatgtcatg aaggctgtca 1074421 gcgcagctga tttacagctt aaggtcaaca agctggaaag cactcaaaca gctgtcagag 1074481 gaagcgcgaa ggaaggcacc cttatcgagg tgatgaacgg caaaaagaaa ctcggcagcg 1074541 ccaaagccgg aaaagacaat gcgttcaagg tgaatatcgc gactcaaaaa caggatcaag 1074601 tactgtatct gaaagcaaca aaaggcgatg cgaaaacatc gtataaagtt gttgtcgtca 1074661 aaggaaaacc ttccggcaca ccgaaagtaa acgcggtgaa aacgaaggat acggcagtaa 1074721 aagggaaggc aaacagcaaa gcgatgatca gagtgaaaaa caaatcaaag aaagtcattg 1074781 cttctgccaa agctgacgca aaaggaacgt tttcggtgaa aatcaaaaaa caaaaagccg 1074841 gaacggtgct gtacgtcacg gctgtggata cagataaaaa agaaagcaag gaagcaaaag 1074901 ttgttgttga aaagtaacca aaaagcggtg ctcgatgcac cgctttttta tttgcgcccc 1074961 cgttggactg ctgtgtacat aatggatcgc tttccgtttg aagccgtcca ttcaaaacgg 1075021 tctcctgtcc cttcgctgct gtagttgtag tgatgctgca tcgcgcattg tgcggtgtca 1075081 tttgaaaagt gataaaagga cacaccctgc cccgccgaag tattcgaaaa gactccttta 1075141 ttataagaaa agacgcaatc gaataccgat aagccgaagc tgtgcaagtg ctgcagaaat 1075201 gcgagaaagg tttcgtcgtc aagcgaatcc aaaagcgcca tgagcggccg cttgactgat 1075261 ttctcatagc ggatgcgttc tccgccggaa agggagatgt tttctgcacc gcatgccaaa 1075321 accaacttgt cctgaaagcc ggcttgctcc cactttcctt tatgatggat ccagattggg 1075381 ctgtgttgga gactgtccgc cagcagtata tcgccttcac cgttttcgat taagcagatg 1075441 ccgtcttcaa tgaggatggt gccgtattcc cactttcgtt cctctgtata taacaattgt 1075501 ttccgtttca tccatgctgt ctcctttttc ttcattcctc tcttttcttt ccaattcaag 1075561 cctgtcccat acaactcttt tatggacaaa tcaactatct gcctatagat gcataaactt 1075621 actaaggtgc tgaaagaaac gaaattgtta cgaaagaaac gggattggag ctgatgtcac 1075681 atgtgtggaa ttacgggttg ggtcgatttt aaaaagcagc tcgtccagga aaaacaaacg 1075741 atggacagaa tgacagacac tctttccaaa cgagggcctg atgattcaaa cgtttggggg 1075801 gagcaccatg ttttattcgg acataaaaga cttgcggttg ttgatattga aggcggacgc 1075861 cagccgatgg cgtgtaccta taaaggcgat acgtacacca ttatttacaa tggcgagctt 1075921 tataacacgg aagatttgcg caaagaattg cgggcgcggg gccatcaatt cgagcgtacg 1075981 tcagataccg aggtgcttct gcacagctac atcgagtggc aggaagactg tgtcgaccat 1076041 ctcaatggca tattcgcttt cgctgtgtgg gatgaaaagc gtaatctgtt gtttgccgcg 1076101 agagaccgtc tcggtgtaaa gccgtttttt tacacgaagg aaggctcttc atttctcttc 1076161 gggtcggaaa tcaaagcaat cctcgcgcac cctgatataa aagcgcgagt ggacagaacg 1076221 ggactttctg aaattttcgg tcttggaccg tccagaaccc cgggcactgg catatttaaa 1076281 ggcataaaag aaatccgccc ggctcacgcg ctgacatttt ccaaagacgg acttaatatt 1076341 tggcgttatt ggaatgttga aagcgaaaaa catacggaca gttttgatga cacggttgcc 1076401 aatgtcagat cgttatttca ggacgcggtg acgcggcagc ttgtgtcgga tgtgcctgtt 1076461 tgcacattcc tatcaggcgg tctggactca agcgcgatta cagcgattgc ggcgggccat 1076521 tttgaaaagg aaggaaaagc accgcttcat acttattcga ttgattacga agagaacgat 1076581 aaatattttc aagcaagcgc ttttcagccg aatgatgacg gaccatggat tgaaaaaatg 1076641 acagaggctt tcggcacaac gcaccacaaa tgcgtcatca gccaaaaaga cctcgttgat 1076701 catttggagg aagctgtact ggtcaaagac ttgccgggaa tggcagatgt cgactcatcc 1076761 ctgctgtggt tttgccggga aatcaaaaag gactttgtcg tcagcctatc gggagaatgc 1076821 gcggatgaga ttttcggcgg gtacccgtgg ttccatacgg cagatgttga gtctggcttt 1076881 ccatggatga gatcaacgga ggagcggatc aagctgcttt ctgactcatg gcagaaaaaa 1076941 ttgaatctga aagaatacgt aaatgccaaa tatgaagaaa ccttggcaga aacgccatta 1077001 ttagacggag aaacgggtgt ggataaagca agaagacagc tgttctattt aaatatgctt 1077061 tggtttatga cgaacctttt ggatcggaag gatcgcatga gcatgggggc gagcctggaa 1077121 gtgcgggtgc cgttcgccga tcaccggctt gtggaatatg tttggaatat tccgtgggaa 1077181 atgaaaatgc atgataatcg ggaaaaaggc attttgcgca aagcgcttga gggcattttg 1077241 cctgatgaca ttttgtatcg caaaaaaagc ccatatccga aaacacatca tccggaatat 1077301 acaaaaggcg tcagcgagtg gctgaaaacg atcagaagcc aaaaggactc cgtgctccat 1077361 accttactgg acagaaaaca attagatcag cttttagaaa cggaaggctc ctccttcaag 1077421 gtcccgtggt tcgggcagct catgaagggg cctcagctga tcgcccatct tgctcaaatt 1077481 catacatggt ttgaagcgta tcgcattgat attgacgaga ggtaggttca atacaaatgt 1077541 gattaaaagc cagagatgta tagatttaaa taagaaggat agatgagcag ggaaatatat 1077601 gctctatcta tccttttttg tacaacagca ctatcgaatt gcccccgcat tccttcaata 1077661 agaatgaata ggttttaatg ttctgccgat aaaactagct gataccgggc ttaactttaa 1077721 ttccctagcc catacagaaa gttgaccaat atggtgaatt tcgtgagcga tgatatggtg 1077781 taatatttca tctcgcgtat ataaaacacc tgtctcccaa ggaacgctta caagttcatc 1077841 ttttatttga tctgaatgtg tttgtaaaac atcaattatt tcagttcgga atgtatttga 1077901 gagagatttc actttattga gtgtttgata atcagcgaac tgaacagcga tatcttcttt 1077961 tccttggata gcacgaatcc aactatattc cacatcaata atatgaaaaa gggtatataa 1078021 aatattctct actccgccaa gacgattttt aagtaattct tcagtggtta gttgatgaca 1078081 ccaagtaaac cattgatctc taacctgcca gttatattca aaaaatttca tcactaaact 1078141 cactccaata ctatcatgta tcataacaat tagccctttt ttccgtgatt cctctattaa 1078201 tgaagtgatg attgagaaat gtttacattc tacctgttgt atggcattaa aaataataat 1078261 gcatatctcg tcgatgatgc tgtgcgtctt gttactttta caaagtaaga atcggcattt 1078321 tcttcatata caattaggaa aaaacatact agacttgaag aagcagtgat acataggagt 1078381 gagaaaatga aagagataaa agaagcttac cagcaatgcg gacagattgt tggcgaatac 1078441 gcgccagcct gtttcaaagc attatcatat ctcccgctaa agcaaagaca agcctcttgg 1078501 gcagtattgt cgttttgcca cacggcggcc agtgcagacg aaaaggtatt gcccgcattt 1078561 gaagctaaag ctgatcatgt ttaccaaagg acaaataacg gtaaacaaca tctatggaag 1078621 gcttttgatc atgcgtatcg gacctttaca ttggaaagcg aaccttttcg ggagtttatt 1078681 gccgcacaaa aagaagacgc caagccgtat gatgaccttg atgaactgct catgtacgca 1078741 tatcggacgg gcggtgctgc cggattgatg ctgctgccga tactgacacg ccgaaaacaa 1078801 gatcagctca aacaagcagc cgtctctctc ggcttggcca tacagctggt tcgcttctta 1078861 agtgatcttg gcacagatca gcaaaaaaac cgcattcccc gtcaggtaat gcagcaattc 1078921 ggctatacag aggctgatct ccaaaaaggc accgtaaata aagcgttcac aatgacgtgg 1078981 gagtatatcg cttttgaagc agaagcctac cttgaagagt gtcaggatgc cttgccgcta 1079041 tttccgcagt attctcaaaa aacggtgaaa gccgctcttc atttgcaccg ggctgtttta 1079101 gaaaaaatcc gggcgaagca gcacgatgta tttcaatatc acttcgctct cacagagacc 1079161 gaagtgaagc agattctgtc tgatatctaa aaaacacccg gccttgattg agccgggtgt 1079221 tacgccatac ctttttgaat ccagatacgt gagcgccatc ttctgtacat taagattccc 1079281 cggacccatt catccgcgat aaaagaaatc caaatgccgg caagaccgaa accgaggtgg 1079341 atgccgaaaa gataagcaag cgggaggcca atgccccaca ttgaaatcat tgccatgtaa 1079401 accgggaatt tcgcatcccc cgcggcccgc agagagttaa tgataatgac attaaacgag 1079461 cggcctggtt caaggataat ggtcatggca atcaataggc ttgcagttgc tataatgtca 1079521 gggctttgtg tgaagagtcc gatcaggtct tttgaaaaga tcgtcatcaa aacagaggta 1079581 gccgcagcaa ttccgagtgc ccaatataag ctcttcatgc agcgctcata agcggcatca 1079641 aattgtttgc cgccgatata acggccgatt aagatttgtg taccctggct gatcgcagtg 1079701 ccgaacagca aaataaacat cgtaatattt tgcgtataca cttttgttgt caacgcctgc 1079761 gcgcccatga tggcgataaa atacgtgact atcatttgcg acaggttgta tgaaagctgc 1079821 tctcccgcag aaggaatgcc gattttcagc agcttgcgca aatgctcttt atgcatatga 1079881 aagacttttt tcagcgacat cttcagctgg atgcgtttgt tgacaatcac aatcatcgcg 1079941 attaatccga tgacgcgggc gatagatgtg gacatggcca caccggcaac accgagaaca 1080001 ggaaagccga acaaaccgaa aatcacaaca aagtttccgg caatgtttaa aatgttcatg 1080061 ccgatagtga caaacattgt atcttttgtg tagccgtagc tttttaagat cgcgctgaat 1080121 gtcatgatta aagcctgaat aaaggacaga cctccgacaa cttgtaaaaa gactttcgca 1080181 tcaggcatca gtgcgtctga taatcccatc atatgaagca gagggacagc cgcgaaaaag 1080241 acgacggcgc tgatggccag gctgatgaag aagttggcgc cgattgacac ataagcgact 1080301 tccatggctt ctttcttttg ccgtgagcct agaaattgtg aaatgataac ggtcgttcct 1080361 gttgcgataa agctgaacat cacgataatt aaatttaaaa tctggttgct gacgccgact 1080421 gctgccacgc tgttatccga gtattggctg agcatcagtg tatcggcatt acccataaac 1080481 atatataatg agacctcaat aaagatcggc caagtaagcg aaaataatga gaacgttttg 1080541 tcagcgggtt ttttcaaagc agttgatttg aagacagctt gtttcatcgt gtctaacccc 1080601 tttcgtaaat aaaatcaacg ttttaaagtg tacctccatt tccttataat aaaaagggat 1080661 agaaacgata cttcttgtaa aaatccgact taaaaaggag gatgattcaa atgcctcgca 1080721 tcctgtttac agtcccgcct tttccggtat ttatcgcagc tggggaaggg gtttttaaaa 1080781 aaggagaaac ccatgtgaaa cgtgtattct ccgtgtttga tctgatatat gtcaaacagg 1080841 gaacgttata tataacggaa aatgaaacat cgttttctgt tgaaggcggc gagtacatct 1080901 tgctttctcc cggtcttgaa cactacggga cgaagggcag tgatgaagca acctcctact 1080961 attggcttca cttcgatgaa catcgatatg aatttacggc aaagggaggc agcaactggt 1081021 ctgagcttca gcaggaaaaa gggagcttcg aagagctggc ccgctacgga ttggccttgc 1081081 cgagaaaagg caaggtgcag cgcccgcagt ttatggcgca gcagtttgaa aagctgatcg 1081141 attactccgc ggaaaactct gatttgccgc tcagaaagca aattttattt gaggagctga 1081201 tgctgcatct tcaaaaagaa gcgttccaaa taccgtctgc gaaagagcgg gtagcctggg 1081261 aggcggcccg gtatttacag gagcactata aggaaaagac gacaatcaag gatctgtcgc 1081321 tcgcccttca ctatcatcag gattatgtga gccgctgcat gcagcaggtg ctcggcgtaa 1081381 ctccggcaca atacacgaac cgggtgagaa tgacggaagc gaagcgtctt ttatcctcta 1081441 caaatgataa aatgggcgtt attgcggaaa cggtcggaat ggaagatccg acatactttt 1081501 caaaactctt taagcagata gaaggcattt caccaattga ataccggaaa attgtcagcc 1081561 ggaaagttca ataaccagac gagggatgaa catgaaaaca acaatttacg atgtggcaaa 1081621 ggcggcgggt gtttcgatca caactgtgtc ccgtgtgata aacaatacgg ggagaatcag 1081681 cgataaaaca cggcagaagg tcatgaatgt catgaatgaa atggcataca cgcccaatgt 1081741 ccacgccgcg gcgttaacgg gaaaacgaac gaatatgatc gctctcgtgg cgcctgatat 1081801 ttcaaatccg ttttacggcg aactggccaa aagcattgag gaaagagcgg atgagctcgg 1081861 ttttcaaatg ttgatttgca gcaccgatta cgatccgaaa aaagaaacaa agtatttttc 1081921 tgtgctgaaa cagaaaaagg tggatggcat tatttttgca acagggattg aaagccatga 1081981 cagtatgtct gctttggagg aaatcgccag tgaacaaatt ccgattgcca tgatttctca 1082041 ggataagccg cttcttccga tggatattgt tgtgatagac gacgttcgtg gcggatatga 1082101 ggctgccaag catcttctgt cactcggcca cacgaacatc gcctgcatta tcggagacgg 1082161 gtcaacgaca ggcgaaaaaa atagaatcaa aggcttccgt caggcgatgg aggaagcggg 1082221 cgtgcccatt gatgaatcac ttatcatcca gacgcggttt tccttggaaa gcggcaagga 1082281 agaagcggga aaattgctcg acagaaatgc tccgactgct atttttgcct tcaacgacgt 1082341 attggcttgt gccgccatac aagctgcgag aataagaggc ataaaagtgc cggatgatct 1082401 ttctatcatt ggttttgata atacgatact cgcagaaatg gcggctccgc ccctgacaac 1082461 cgtagcccag ccgataaaag agatggggcg gagcgtcatc gaactgctgg cagaagcaat 1082521 agagggaaaa cgaaaggcga aacaaaaaat agtgctcccg cctgagcttg tagtcagaca 1082581 ttctacatca ccgctcaaca catgagcccg ctaatgagcg ggttttttca ttatgacagt 1082641 tgaagccaaa aaaacatatt gcgtgtaaac caaaggcggt gtaaaatata accatctttt 1082701 gagaaagcgc ttgcgcaaaa tggcagagcg gatagaaccg ctgttttttt agctgttaag 1082761 agaaaacgct ttctcaaagc gagcccgaaa tgagataaag gagaggatgg gacgtggaac 1082821 atcaagtaag atgtgcagta ttgggattag gaaggctcgg ttattatcat gcgaaaaatc 1082881 tcgtcaccag tgtgccgggg gcaaagctgg tttgtgtcgg tgatccgtta aaagggagag 1082941 cggagcaggt tgccagagaa ctcggtatcg aaaaatggtc agaggacccg tatgaagtgt 1083001 tagaagatcc cggcattgat gctgtcatta tcgtaacgcc gacaagcaca catggtgata 1083061 tgatcatcaa agcagccgag aacggcaaac agatctttgt tgaaaaaccg ctgacattaa 1083121 gccttgagga atcaaaagca gcttctgaaa aagttaagga gacaggtgtc atctgccaag 1083181 tcggctttat gagacggttc gatcccgcat acgcagatgc caaacggcgg atcgacgctg 1083241 gagaaatcgg caaacctatc tattataaag gctttacgcg cgaccaaggc gcgcctcccg 1083301 cagaatttat caaacacagc ggtggaattt ttatcgactg ttccatccat gactatgata 1083361 ttgcccgtta tttgctaggg gcggaaatca cttctgtttc aggacacggc aggattctga 1083421 acaatccgtt tatggagcag tatggcgatg tggatcaggc gctgacgtat attgaatttg 1083481 actcgggcgc agcgggggac gtcgaggcaa gcagaacctc tccatacgga catgacatcc 1083541 gggcggaggt gatcgggaca gagggcagta ttttcatagg gacattgaga catcaacatg 1083601 tgaccatcct atcggctaaa gggagcagtt ttgatatcat tccagacttt caaactcgtt 1083661 ttcatgaagc ctactgcttg gagcttcagc atttcgccga gtgtgtccgg aatggaaaaa 1083721 caccgattgt gactgatatt gatgcgacga tcaatttaga agtgggtatc gccgcaacca 1083781 attcctttcg aaacggcatg ccggtacagc tagatgtgaa gcgcgcttat acaggtatgt 1083841 aaaagctaag tatgttgcat ttgaggcttt ccgcaaaaaa agcaagggca ttttagccct 1083901 tgctttctct tttctcatat aaatagtaca tataatcagt aggtacgcct gaatggtcca 1083961 gctgtctcag catggcggtt acgttccctc tgtggtaagt gccgtgattg acgacatgca 1084021 ggatggtgtc tgcataggtt gattccagtg tacctagttt cggatgctgc attgtgaagg 1084081 tctgttctaa gtccgtctgg cggctgaaga aatcatgata ctgtgactcc agctcggcag 1084141 cgtgctgttt aatcgctgcc atattacctt gcgcggactg taatttgcct gcgctgtcta 1084201 taatctcttg gtaggccact cccgaaagaa cattcagcca aatgtagtca gccctgcaca 1084261 tatgaagcag cacgtcgctg acagaaggaa atacgctctt tacttcttga taggcagttt 1084321 cctccggcag gttttcgata tgggtaaata ttttcttgtt tgcccaagaa tgatagtcat 1084381 aaaactgttt tgcatcagtc atcagcatgc ccccttttct aagaaattcg tttttttcat 1084441 ctgtttctcc ttcaattgca aaagagtgac accccaaaat atcctgccgc tgcccacatt 1084501 accgctgcag agcatttgtt tacgatcagc ataagcctgc cgctcgtatc tatcgtctga 1084561 aacaaccggc ccgctattgc aaggctgatg aaccaaatcc aagacacagc gatgcaggcg 1084621 gccataaaga gccatttctc aagccccgaa tattgaagag agctcgtgcc gatgacgccg 1084681 atcgtgtcca gaatggcatg cgggtttaaa agagaaacag cggccgcaaa cgcagcttgc 1084741 ttttttggtg tgaacgtatg tttctcattt tggcttgtgt tcggacggat gttccaagtc 1084801 acccagccca tataaagcaa aaataaaaat ccgccggcca tcatgactgt ctcaaacaca 1084861 ggcagctcct gcacaatgac agacacgccc gcaacggcta atacaattaa caaggtatcg 1084921 cagactgaag cactgatgac agctgggaga gcccgccaaa tatgcttttg caacgcgcct 1084981 tgctgaaaaa taaacacatt ctgcactccc agcggcaaaa ttaagccaaa cgcgagcaca 1085041 attccgtgaa tgattgcatt catgctgaaa aagctccttt cacatttttt ttcaatcata 1085101 agagagattg tcactaaagt ctccagccat ttggttgggt taggaaccag ccaaatgtat 1085161 aatgtgtaaa aaaggggggc atgaccttgt cgcaatggca gccaagccga aagtcggatg 1085221 ttccgctgca tcggcagatc gaacaatata tgaaagacaa gattcttcac ggagagtggg 1085281 ctgtagggac gaaaatcccc tcacagagaa cgctggccga catgtttcaa gtcaaccgca 1085341 gcacagtcac agcagccata gatgaactca cgtctcaagg cttgttagag ggaagaaaag 1085401 gcggcggtac gaaggttgta aacagtactt ggagcgtgct gacggctgag cctccgcttg 1085461 attggagcga ttacgtccgt tcgggcattc atcgcgccaa ttcttccatc attcaagcta 1085521 ttaatcagaa cgaaccaaga gcggatatca tcagattagg aactggagaa ctttcaccgg 1085581 atcttgtgcc tgctgacaca attggacgga tgtttcagca aatcaatccg ggcgtcctgt 1085641 ctttaggata tgagcagccg aaaggaaacc gtcagctgcg ggaggcagtg gccgaccatt 1085701 taaaaggaaa gaagatccat gtgtcaccgt ctgcaatttt aattgtgtcc ggtgcacttc 1085761 aggcacttca gctcatctca attggacttt taaaacgaga ttctgtcatt ttgacggaga 1085821 agccgtccta ccttcaatcc ttgcatgtat ttcaatcagc tgggatgcgg cttcgcggct 1085881 tgccgatgga tgatgaaggg gtcaaagcgg ggcttgtttc ttctaatcga aaacaatatg 1085941 gaggacagct gctttacacg attccgtcgt ttcataatcc gacaggcaca gtcatgtcag 1086001 agcagcgaag gaaagagatc atcagcctgt caaaaaaaga gcagatgccc atcattgagg 1086061 atgatgcgta cggtgattta tggtttgaag aaaaaccgcc gcagccgttg aaagcaatgg 1086121 atcatgaggg caatattctg tatctgggcg cgttttcaaa aacggttagc cccggtctgc 1086181 gaatcggctg gcttgccggt ccggagccgg ttattgaaag gctggcggac attaaaatgc 1086241 agacagacta cggatcaagc ggcctgtccc agtgggcggc tgccgagtgg ctgtcacagg 1086301 gatattatga agagcatctg acttgggtac gcaggaagct taaagaaagg agagacgccg 1086361 ccgttcattt tctcgagcgg tatgccgggg acattgccac gtggcggatt cccgcaggcg 1086421 gcttttatat ttgggtgaca tttcacaaaa acctgcctgt cagccgtttc ttttatgaat 1086481 tgctgaaacg gcaggtgctt gtgaatcccg gctatattta tgacggtgaa gaccgaaaca 1086541 gcatcaggct gtcatattcc tatgcatctc ttggagattt ggaaactggc attaaagcgg 1086601 cagctgaaac agcacgccgc ctgatgatgt cctaggcttt ggttatacga tgacagctcc 1086661 cagtgccctg gcgaaggcaa tcgcgtgctc aggtgcgatt ttgcagcctt tcaatttgtc 1086721 gagggagaca tgaagctgtt caaaacggca cgtgctgatg tccatgtttt gaagggacgt 1086781 gccggtaaag ctggcgcctt ccaattcgca tccgtcaaag tgtgtctgct ggagcaccgt 1086841 atcgctgcat tcactttgca taagagcaca gtgatcaaat cgaacttgtt tcatatttga 1086901 gtacgaaaat gagctgaaat gtccgtggca ttcctcgaat gaaacattcc gcagcgttgc 1086961 ttccgccaca ttcattccaa ccatttttga ctgcttaact gaagttctgt gaatgacagc 1087021 cccgctgaaa tcggcgtttg ataaatcgca tttttcaaag atcacatcgg tcagttcaat 1087081 atgccgaaaa gacacatcga taaagacgac atttctgaat accgtttttt caacacatag 1087141 tctttcgata tcttcgccgc agatggtgca atcttcaaac aaatgcatgc tgattacatc 1087201 atcctgtgtc acggcatcat gaaaatctgc ggtttgcagg ttttccggta tgttcggttt 1087261 ttgaattgcg attttattca tgtgatgaca tcctttgctg cccgaaaaac agaggcttcc 1087321 gggttcaatt taatagatcg ttaaggaaat tgatacatat agtaaatcgt gaagagcctt 1087381 ttcttggtac agcagcccgc ttgttttgta agcataaatg gaaagcttcc tatacgtcaa 1087441 ggcgtttaca ggccgaaaaa gccaaaggga acaggaggaa tgcggaatgg ggcattacat 1087501 caaaaccgag gagcatgtga cactgtttgt agaggatatc ggacatggaa ggccgatcat 1087561 ctttttgcac gggtggccgt tgaatcataa gatgtttgaa tatcaaatga atgagcttcc 1087621 gaaaagggga tttcgtttta tcggcgttga tttgcgggga tatgggcaat ctgaccgccc 1087681 ttgggaaggc tacgattatg acacgatggc cgatgatgtg aaagcagtca tttatacgct 1087741 gcagcttgag aatgcgattc ttgccggttt ttcaatgggc ggcgcaattg caatccgtta 1087801 tatggcaagg catgaaggag ccgatgttga taagctgatt ttactgtctg cggcggcccc 1087861 cgcgtttaca aaacgcccgg gttatccgta cgggatgagg aagcaggata ttgacgatat 1087921 gattgaattg ttcaaagctg atcggcccaa aacactggct gatttaggga aacagttttt 1087981 tgagaaaaaa gtgtctccag agcttaggca gtggtttctc aatctgatgc tggaggcttc 1088041 ctcctacggg acgatccact cgggcatcgc attaagagac gaagatctca gaaaggaact 1088101 tgctgcaatc aaggtgccga cgctgatcct gcacgggaga aaggatagaa ttgcgccgtt 1088161 tgattttgcg aaagaattga agcgcggcat caaacagtcg gaattggttc cgtttgcaaa 1088221 cagcgggcac ggagcatttt atgaggaaaa agagaagatc aacagtttga ttgcgcagtt 1088281 ctccaactca taagaaaaaa cccgacattg atcgggtttt ttatataatt cctctgtttt 1088341 gcagtgcgtt aatgatgaga tcagctccat cggaaataga ggtctggtca gactcaatga 1088401 tgaaatcggg tgaaagcggc gcttcatacg gagaatcgat cccggtgaaa tgtttgatct 1088461 ctccgtttcg cgctttttta taaagccctt ttggatcgcg ctgttcacaa acatgcagcg 1088521 ggcacttcac ataaatttcg aagaactcac ctttaggaaa gagcgctcta accatgtccc 1088581 gatcctctct gaatggagaa ataaaagccg ttaaaatcat ttgcccgctg tcgacaaaca 1088641 gcttcgccac ttctccgatc cggcggatgt tttcaatcct gtcaccagtc tgaaatccaa 1088701 gatctttgtt taagccgtgg cggatattat caccgtcaag cacgtagctc tgaatgccct 1088761 tgcggtaaag cttttcatcg acagcattgg ccagcaccga ttttccggag ccggacaaac 1088821 ctgtaaacca aaggacgcag cttttgtgtc cgtttaagga ctgtctgtca gactttgaga 1088881 tggcagcggg atgccaaatg atgttcggat tgtgtgtcat tgcaattccc cgctgttttg 1088941 cttgatggca acaggctgtt ggtgaagtcc cttgatcagc acggctgcga cctcaggccg 1089001 gctgaattct ttaggcggct ttttgccttg gcggagaagc tctctcactt ttgtgcctga 1089061 taagtggatg tggtctctcg ggctgtgcgg acatgttttg gaggtgccca tgtttccgca 1089121 ttttcggcaa taaaagctgt gctcaaaaaa cagcggcttg atgcccagct cttcctctgt 1089181 gaatgattga aaaatatttt gggcgtcgta tgttccatag tagctgccga cacccgcgtg 1089241 atcacggcct acaataaaat gggtacagcc gtaatttttt cggacgagcg catggaaaat 1089301 cgcttcccgc ggacctgcat aacgcatggc ggcagggaaa accgataaca tgacacgatc 1089361 ctttggataa tagtgattaa gcaaagcctg gtagctctcc attctgatat cgctggggat 1089421 atcgtctgac tttgtttctc cgacaagtgg gtgaagcagc agaccgtcga ccgtttctaa 1089481 cgctgttttt tgaatgtatt catgcgctct gtgaacaggg ttcctggttt gaaagccgac 1089541 aatcgtcttc cagccgagtt tttgaaaggc cgctcttgtt tcagcgggcg ttgcataaaa 1089601 ctgttcgaaa gatttgtcag gcaggctgct gaccgtgata ggccctccga tatagtaatc 1089661 cgggcgcgcc agcaattttt ttacgcctgg gtgggcagga tcgtttgttt taaaaacaga 1089721 cagtgcttct tgtgttttat caggctggta tatatcggtg actgtgatca tgccgtaggt 1089781 aacaccgtct ttcacaagct tgacgtgatc tccggcagac agctgtcttg ctgttttttc 1089841 tccgacaggc agcgtaatcg gcaggctcca cggcaagccg tttgccagcc tcatctcttt 1089901 cacaacggaa tgataatctt tttctcccaa aaaacctgtt aacgggctgt agccgccgat 1089961 cgcaataagc tccagatcac tcagtgcaag ctgatccagc tctgcttggc acgcgcaccc 1090021 ttcaaaatgg catgcgggat cacagcggtt gattaatacc cctccgtggg gttcgtttcc 1090081 attcaacgtg ttcaacctcc atttatacgt ttccttgttt tcttttctgc acttaatgaa 1090141 agtttgacat cagcgcctta acatcatttc gattctcaca tcaagaacct gccatccgct 1090201 attcttgatg caggccgcat tctgttttct cccgtccggc ccatcttcca gccctctcat 1090261 cgttcgggtc cggggaaggc agtgtacaca tttcacagcc tatgctcgga taatgttgat 1090321 cgtgcagttt gttataaggc aaattgtgca ggcggatgta cgtccaaacg tcatcccatg 1090381 tccagtggat aagcgggcaa attttgatga gctcaaactt ctggtccagg tttacgtatt 1090441 gaatatgctt tctcgttggt gactgatccc ggcgcagtcc tgaaatccaa gctgtcatgc 1090501 cggacaggtg ctttttgagc ggttcgattt tccgcaattg gcagcagagg ttcgggttat 1090561 gcttccacag ctctccgccg tacttcgtcc cctgttctgt taagctcagc tcgggttcga 1090621 gcatctggat tgcaaatccc ggatatcgtt ctttgacggt ctcgatcagc tcatatgttt 1090681 cctgaaaatg aagcccggta tccaaaaaga tgatgtgtgc gtttttgttg atttttgata 1090741 ttaagtcgag aagcaccatt ccttctgcgc caaagctgca ggcgtacaca atcttttctc 1090801 cgtacgttcg gtaagcccat ttcaacacat cgagctcatc gatcaattga tccgttatct 1090861 gtttggacag catgtcgttc caagtgtcat atgtgatggt ttcgttcaat gttttccccc 1090921 cgtttgcatc tgcttttttt atctattgat cgagttatag gcagactatt cattttttgc 1090981 ataaaggttc aggttttagg tgccgcgccc gcctaaaatg aggtgcggaa ccattaagag 1091041 cccggctgaa tatgcttttt agcaaaatgg ttttatgccc aaggagaggt agtatgccga 1091101 ttgccattta tcaggggcat catcattcgc ttgccccggc ggacattaac atcgtcattg 1091161 atgtcatcag agcctttacg gtcgcccatt atgcgtttat cggcggggcg aaagagattt 1091221 tgttggtccg gacagctgat gaagcctttg cgctgaaaga cacctatccg gattatgttt 1091281 tgacgggaga ggaaaagggg gtcggtatca gcggatttga tttagataat tctccaaaac 1091341 gtatggctgg gcagaatatg acggataaaa gcctgatcca gaaaacaaca aacggcgtca 1091401 cagcagcatt gggggcgctg aacgcaaagc atctgttcgt aactggattt tccaatgcca 1091461 aaacaacggc acagcatgtg aaaaagctcg tcgcaaacga ttgtgtcata aacatagtgg 1091521 cttcccatcc atccggtgat gacgatatgg catgtgcgga gtatatcaaa ggcatcattg 1091581 aagggacaaa tgtggtaacg gctgcggagg cgattgaaag aataaaaggc tcttctgttg 1091641 cggagaagtt ttttgactgc cgccagccat tgtttgattc ggaagacatc gtttactgta 1091701 caaaagaact gacgggcgat ttcgtgatga aagtgaaaca agatggagaa gttccaacga 1091761 tagagagggt cataatatga atgatttttc actagaattg ccagtgagaa caaacaagcc 1091821 gagagaaacc gggcagtcca ttttaattga taacggctat cccttgcaat ttttcaaaga 1091881 tgcgatagcc ggagcgtccg actatattga ttttgtgaaa ttcggctggg gcacatcatt 1091941 acttacgaaa gatcttgaag aaaaaatcag cacactgaaa gaacatgaca ttacattttt 1092001 ctttggcggc acactgtttg aaaagtacgt aagccagaaa aaagtgaatg aatttcatcg 1092061 gtactgcacc tatttcggct gtgaatatat tgagatttca aacggtacgc tcccgatgac 1092121 aaataaagag aaagcggctt acattgccga tttttctgat gaatttcttg tgctcagtga 1092181 ggtgggcagc aaggatgcgg aattagcaag ccggcaaagc tctgaggaat ggcttgaata 1092241 tatcgttgag gatatggaag cgggcgcgga aaaagtgatt acagaagcca gagaaagcgg 1092301 aacgggaggg atctgttcca gcagcggcga tgtcaggttt caaattgttg acgacatcat 1092361 ttcctcggat attgatatca acaggctgat ttttgaagcg cctaacaaaa cgcttcagca 1092421 agggtttatt caaaaaatcg ggccgaatgt gaatcttgcc aatattccat ttcatgatgc 1092481 catcgcgttg gaaacgctgc gtttagggct aagatccgat accttttttc tgtaaaatag 1092541 cggctgcggg gctctcgtcg tgaagagagc ctctgcctat tattttttat ggcggtacat 1092601 aggcgtgaga tagggaagtg aggtcaggcg gatgttgtag atgaagtcga tgactcttgt 1092661 cgatatcacc tggcatatga gggcttgaat gacgatgccc cagtcaataa tagacgcggt 1092721 gaccataaaa atgatgcaat tcatgatgag caggatcgtt ccaggattcc cgccgcggta 1092781 gatagaaatc atcagagcaa gggctccgaa tcctccgttc gaaattttat atttgtataa 1092841 aagtccgatt ccgagtccca ataacactgc gccgcttgcc agatcaagcc acaggttaga 1092901 tgtgatatca ggaaaaactg catcaaagat caataccgag acagaggtga cggtgataga 1092961 agcgagggtg ccggtgaatg ttctcatctc cagccatttt aaagcggtaa aaagcattga 1093021 tacattcaca gcccacactg aaaatccgtg ggggatttga aacagataat gcaatagcac 1093081 cgcaatacct gctgcaccgc ctgtcggaat atcatgcgga aataaaaaca aggacatgcc 1093141 gagtccttgt agtacgccgc ctacgacaat cataaacgta agttttgctt tcatcagcag 1093201 ttcagccatt aagtcatttg ctcctttatg aaaagacttg tccgctgttt tcattttatg 1093261 aggctgtcca ttatttatgt ctcaaaataa agaaatggcc cagcttaata ggctgagcca 1093321 tcccacttgt agcgattgac gatctccata ttgatctctg tgccaatgcc ttttcctttc 1093381 gggatgtgga ccattccttt tgaaggctgc aggctgacga gatctgtaaa aggattctcc 1093441 atgacgtccc actcgatcgg ttcaatgtga tcgttcttca ttttagacca tgggggcaga 1093501 caggcttgtg caaataaagc atagagccgt gagagcgatc cgtcatatgc atgggcggat 1093561 gctctgacgc cgaaataacg cgcgagctgg aggcagtccc gaaactcatc aattccgttg 1093621 acatgcatga catcgggctg aatgatatcc aaacagcgct gtgaaaggag aggcacatat 1093681 tgcgccgggc ctttcatgtt ttctccgccg gcaacaggaa cagacaaacg gcttcgaagc 1093741 atagcgtaat cctgcggctg atcaaagggc aaaggctcct caagccagcc aatgttcgtc 1093801 cattcggaga aatagcgctc ccatttaaaa gccgcagcgg catcgtagct ttggtttgcg 1093861 tccagaatca tcgtaatgga gctgcctgct gtatgctgca gcgcattgat gtgccggaca 1093921 tcctccttga atgaagtccc gccaattttg actttgattt gctcaaaacc ttttttcaac 1093981 tgggcttcaa cattggagac tgagcggctg atccattgcg gggagtctga gtacgattga 1094041 aaagacgcgt acacaggaat ctcctctctg tatcgcccgc cccataattc gcaaaccgaa 1094101 caatccgcag ctttggctgc aatctctgtc agcgccatgc ttacagcgga ggccgcccgc 1094161 tggtgccatt tttgaatcgt gcgcactaat gacaggcggc tgccagcctg ttttcctaat 1094221 agaaatggga tgatccgctt cgtaaaaccg acatggagag cagggagcca atcaacgcat 1094281 tctccccagc cgtctatccc gctttcggtg ataatcctga tgagataaca agtccgatat 1094341 cgtttaaacc cattggcatc tccgtatggc ttttctaatc gatgaaatag cggaaaggtt 1094401 tcaatccgta caattttcac actgggtgct acctttcctc agcgggctgg agccgattgc 1094461 cagccatttt agggtcttct ttttcttttg tttcttcatt gttttgcttc acatggatga 1094521 gcatcatcac aagaatcccg acaacgagag tcaatcccgc gatgcttaaa aacatgccgg 1094581 gtctggacca ttgcatcagg cggccgaaaa tcggaggacc gatcgctacc cctaagaaac 1094641 gtacagagcc gtacagcgag gtgacaaatc cccgtctttc tttgccgaca gccccggtaa 1094701 tgaaactgtt cacacaagga aggacaagac ctgagcctat actgctcagt acaagaacac 1094761 tgataaaaag gacaagattt tcaatgaatg acagtgccgc gtaggatacg gtcatgaacg 1094821 ccaatccaag tacgatcagc tttttcatta acgattgctt ttgcccgatt ttgcttcctg 1094881 ttgtatagga cgtcacacac ataaccaaaa gcgggatcgc taaaattaag ccttttttca 1094941 cgccgtcggt gtcgtatgtt ttttcaagaa catctgagag ataaaacagg atgccgaata 1095001 aagtaaacaa acaggtcgca ccggctaaat aagcggtaaa cagccatctg ccttcatgtt 1095061 taaagacact taacagccct tttgcatatt gtccgattgg tggcggttct ttttcctttt 1095121 tcttttcttt aataaaaatc caagtcagta cgatcgaaat gatacaaaac acaggaaagg 1095181 caaaaaacgc gccataccag acaagcaggg cgatcagcga gccaatgatc ggcgatagca 1095241 ctttccccat gccgtttgaa gcttcaacaa ggccgagcac cttgctctcc tgggcgcctt 1095301 taaacagatc tcccgtcagt gccatggcaa ttgggccggt tccggctgcc ccgattccct 1095361 gtaacgctcg tcctgccatg acccaaggat aggcattgtc aaaaaaacct gccgcaaacc 1095421 cggctaacaa accgccggca ccatacaaaa ttaagcaggg aataatgatg actttccttg 1095481 agaatcggtc tgcgagataa ccgacaatcg gaatcgcaaa tgctgcaatc aaggaaaata 1095541 ctgtgatcac gagactgact tgaaattgtg ataaatgaag ttcagatttc atttttggca 1095601 aaatcggaat aagcatcgag tttcctaggg ttaatattaa agggattgaa ccgattgcca 1095661 caatcgtcat tccgttattt tgttttgatg attccatctc agagcacact ccttttcttc 1095721 tgcttagaat gtccctgatg gcttcgttta ttcagcgatc agacagcaaa aaaccgaaca 1095781 gaagatacct gttcgggaaa aaagagggtt aaccgagagc ctgtgaaatc aaagcatata 1095841 agtgtccatt ttgaataggc gcttttttct gatagaacaa aatcggaggt tcatcatctt 1095901 tatgaaatcc catttctatc aggctgtcat gcagagacgt gtgttcactc ggtatatcga 1095961 ttcgcatcgg cccttgtttg ccggccgcca gccttgtaat tatctgtgct gcaacatctg 1096021 atgatggagc gatgataggg ccgaatttca aattggccgg tgtctgtaca gaaagtccgt 1096081 agccaatgag ctgtccgtcc tgatttctgg cgatgataca ttcgcatgaa gcagaaataa 1096141 gctgctgcaa aaggtttgat cgatctccgc caaaggcagc cagatccgcc gcggttaagt 1096201 cgtgaaagtc ttgttctcta aaggatgtca gttcagcatc aagctttttt gtataaggtt 1096261 gaaaactgtg acagctgtac tttcgcactg aacctgccgt atgaaaacct gctttttcat 1096321 aaagcggcaa accttctttt gtggcgcaaa gcctgatggc ggtgttttca tccgtttggg 1096381 taatacaggc gtttaccata cgccggccaa gaccgagccg ttgatattcc ttgtcaacga 1096441 taacaaggcc gatagaagta agacggccaa acaaaaacaa gccgatgcag gaaataatat 1096501 caccgctgac attttgataa ccgaaaaagc gtccctgctg aacaagcagt ttcagctctt 1096561 gttcgccata atccggccac ccggcttgcc cgcaaagccg caataagccg gaaacgtgtt 1096621 cttcatgaag cttaatcagt tcatctacta cgtccataag atcacctgct tgttctaagt 1096681 gttttgtaca tgacaatatg attgccaatg ccgggaatgt caaatggttc gccaagttcc 1096741 ttccagccaa gcttggcata gtagcccttg acatggtgtc ttgcgttgca ccataccgcc 1096801 tgaacgccgc tctccgccag tttgtgctcc gcgtgtttga tcagcgtgct tccagctttt 1096861 tgatcgcgat atccctcgag cgttgccatg cctctcagcc gatacgcaga ggcttccgtt 1096921 aataaaggct gactttgcgg ggaaaaagaa gcgatgctga tcagcgttcc atcataaaac 1096981 acgccgagat gaaaggagcc ttctgcgtga tcctctttat atttgcattg ttcgatggat 1097041 tgatggggac gcagaatgcg atgccggatt tcatatgtat cttccacgga aatggttttg 1097101 acttcgagca taatgttcct cctcatgatt gtttttctat atcgtaacac gaatctcgtt 1097161 gaaaaagact gcccgattcg atcaggcagt cttttggaaa ttaatgcaaa aagatatttt 1097221 ggcgctgctc atctttttgc tgaatatatg atgtgagctc agcggttaag tcagatctga 1097281 ggaaaggcgt tatcaagtag atgccgttaa acagctcgca tgccgtatcc agcagggagc 1097341 gtgcaattgc aaggccttcc gccttttgct tttctttatc ttcaccggca tgggccattt 1097401 tttcgcgaat cgtatcagac agcttaatgc cgggaatttc attatggatg aattcggcat 1097461 tccggctgct tgtcagcggc atgatgccga tatagatcgg cgtcttcaga tgttttgttt 1097521 cgttatggat atcgacaagc tgctgctcgg aatagacagg ctgagaaaca aaataatctg 1097581 cgccgcaatc tatttttttc tcaagccgtt ttaccgcttt atccagatgg cggacgttag 1097641 gattaaatgc ggcggcaact gagaaattcg ttttcttgcc gagcggtttt ccagacagag 1097701 acagaccttc attgaattgt ttgatcagcc tgattaaatc aaaagatgtt aaatcatata 1097761 cagacgtcgc cccaggaaaa tccccgattt tagaagggtc acctgtaata gcaagcacgt 1097821 cattcagccc taacgtatca aggcccatta aatgtgactg taagccgata atgttacggt 1097881 cacggcacgt aatatggaca agggaacgca tatcgagctg ctgcttgaca agggcgccgc 1097941 aggcaacatt gctgatccgc ggggtcgcca aagaattgtc ggcgagtgtc agggcatcga 1098001 ttcccgcttc ttttaattca gcagcagcgg acagaaattt gtcaaagctt agttttttcg 1098061 gcgggtccag ctctacgata atagagcgtt ttttcgctgc gatctcatcc aggccgggct 1098121 cggttcgctc gtgatgaaca gaaatgaatt ctttcgcccg ggttttgact tctttttccg 1098181 taatcggagc cagcccgcca accgcttccg ccatcgccct gatgtgattc ggcgttgtgc 1098241 cgcagcagcc gccgataatc cgcgcacctt gcttacggaa ttctgacgcg ctgttttgaa 1098301 aatacgtgtc gtctgtttca tagacgagcc gtccctcttc aagcgaagga agactgctgt 1098361 tcggataaac ggataagaat acgtcatcaa aaatcggcac ttcgcttagc gcttcaatca 1098421 tgtgataagg gccgaggcgg cagttaatgc cgacaatatc agctccgaga tccgcaatcg 1098481 agcgcaatgc gtcagaaagc ggcgttccgt cctgcaatac gccttgctcg tgcatggaga 1098541 cattgagcat aatcggaaga tcagtctctt tgcgcgcgat tttcagcact tcacgggctt 1098601 cttccaaatc ataatatgtt tctaacagca agccatccgg ctcttcatgc agcagcagat 1098661 acagctgctc gcggaagctg cgcttaattt cgtcaagact gtatgcgttt ttattaaatg 1098721 tgcgtatgcc gcccatcgtt ccaagcacgt atgcatcgcc tgctgaagcc cgcgcgatct 1098781 ttacggcctc ctgattcatt tttttgatgt catcctcaag cccgtgtctg gataatttaa 1098841 tatagttggc tccgtacgta ttcgtttgaa taatgttggc tcccgcttca acgtacgctt 1098901 tatgtatgcg ctgaatttcc tccggctttg aaatattgag ctcctcaaaa cacctgtcaa 1098961 tgccatagga gtagaggagc gtccccatgg cgccgtcacc gattaacacc tgtctttgca 1099021 aatcttctaa aagtcccatt gtctgcctcc tttattcaca tcagcaagga aaaaagagaa 1099081 ataaaaaaag tcctcttaag aagaagactt tgtcagtgat tttgtctctt cttatcttcc 1099141 aagctgttcg agcttgctgg atttagcacc ttggtcatgg ctgatcgcca ttacaccggt 1099201 tgctgaagct tcgtcgggcc agtccctctg cttctcttga taagaacgga tatgaaattt 1099261 tcgtgtcagg aagtgccaaa agatatctgg cgtttttccc tttctccaaa tttaccgaaa 1099321 ataaagacaa taatcaatag gaatcagaaa atttatctga aatttataaa ttgaacgtca 1099381 attggcagat ctgctccccg tacagctgag ataatctgct gcaggtcatc tttgtttttt 1099441 ccggtgacac gcacttgatc atcctgcacc tgagacttta ctttcagtcc ggagtttttg 1099501 atgatcgtat tgattttttt tgcgttgtcc ttgtcaatgc cttgaacaag ctttgcacgc 1099561 tggcgcaccg ttccgcctga cgcgttttca accttgccgt aatcaatgtt ttttgtcggt 1099621 acgtttcgtt taatcaattt gctgaccagc acatctttca gctggcttaa tttgaattcg 1099681 tcatcggaaa cgaggaccag ctcctcttta tctaaagaaa tgtcgctttt gctgccttta 1099741 aagtcatatc gggtactgat ttccttcagt gcgatttgga ttgcgttttg cacttcaggc 1099801 aattccacct tggatacaat atcaaatgaa ctttcttttg ccatatgaaa acctccataa 1099861 catttaactt atgtgttgat tatagtagaa taaagagaaa cttccaacag aacaaagaat 1099921 caatttgtga tgattggaaa aaatgttaac aaaatccgca gagaataagc ggaacaggaa 1099981 ggacgatagc atgagaccag ggcagcaatt aaccttgagt atagatcacc aaaccgactt 1100041 cggttacttt ttaaccgatg gggaagatac gattctctta cataacagtg aaatgactga 1100101 ggatatcgag gacagagacg aagtagaagt ctttatatac gtagaccagc aggaaaggct 1100161 tgcggccacg atgaaaattc cgatcatcag cgcggatgaa tatggctggg ttgaagtggt 1100221 ggataaagtg gaagatatgg gcgttttcgt tgatgtcggt ttatcgaagg acgcactagt 1100281 cgcaactgag catttgccgc cgtacgaaga tgtctggccg caaaaagggg acaaacttta 1100341 ctgtatgctg aaggtgacga accgggggcg catgtttgcg aaaccagcgc cggaagatat 1100401 catcagcgaa ctgtttaccg acgcttcaga agatctgatg aataaagagc tgacaggtac 1100461 ggtgtacagg ctgatcgcat cgggttcatt cgtgatcacg gatgacggta tccgctgttt 1100521 tattcacccg tcagaaagaa aagaggagcc aagactgggt tcaagagtca caggccgggt 1100581 gattcaagtg aaagaagacg gttcagtcaa cttgtcgctg cttccgagaa aacaggatgc 1100641 aatgtcagtt gatgctgagt gcattctaac gtatatgaga atgagaaacg gtgccatgcc 1100701 gtacagtgac aaaagccagc ctgacgatat cagagaacgt tttaatatga gcaaagccgc 1100761 ctttaaacgc gcgctgggcc atttgatgaa aaacggaaaa gtgtatcagg aaaatggatg 1100821 gacatacgag aaaaaatagc atgaaaacgg ctcgcctgca gcagactgcg gagcgagccg 1100881 tttttttatg tctagtttaa ttcatcaacc agcgttctga ttgccatttc gcgatccaca 1100941 ttgtctgaaa tcgcaatcgg cgtaatatca atggcgagaa tgatcagaat cagggcacct 1101001 gctgcagcaa cataagaaac ataatagaaa tagttagcgg tatcaacagt gttgacaagc 1101061 tcggcctgaa ctctggatgt atcatcctta gaagcggcga tttcctttgc agcttctact 1101121 ttttcttcaa cgatttgacc tgcttttttc agcagttcat ccactttcaa tgcatctttg 1101181 ctgtaaacag ctttcttcag gttatcaaaa aagtcagcat cctctttttt aatatcagcg 1101241 acaacctgat tggcaaaagc ctttgcctgt tttgtgttga gtttgtctgt catcgcttta 1101301 ttaaagacct ctggaagctg tttgccaact tccccttggg caaacacaaa gcctttaaaa 1101361 atttcctcac ctgaatactc aagctgcttt gcctgtgcca cactttcttg ctgcttcacc 1101421 aaaaacacag tcgtcaccaa tacaaccgac aaaaatacta gaaacgcctt cttcaaactg 1101481 aaacctctcc cttcttgtgt tttttattcc acaacagtct gcgaatatat gtaaattgaa 1101541 tcgtggaatc gataggagtg agatacaata tcaaaatgcc ggccatgata atcgaaaaac 1101601 tgatgaggcc cagcatgact gcaaaaatct catgcataaa aacagcgatg atcaaaatca 1101661 atctccaatg cttcttcggc gcaaacagtg ccgcgaagat gacaatttga accagcagcg 1101721 tcccccatgt cggaatcacc acgaacggac ttgttacaat tggcttcgtt aacgcctgaa 1101781 aaaagccgtt gaagccaatg gttttttcct gggcgaaata atagacggcc gttccgtcca 1101841 cccattcctg ctgagatagc ttagcgacgg tagagtgaaa ataaagcacc gccacttgga 1101901 ttctgatcac aaaataagaa ataaaagctg ttatttttcc aagtgttctt ttgccctcta 1101961 taggtctcgt actccaatgc cattttctcg gatcggtcag cgtgatggga agcaataaaa 1102021 aggtcatgac tgctgctgcc tgctcgcctc cgtcgatgac gatcagcgat gactgcaggc 1102081 tgtaactgac ataccaatgc agaaccccgg tgattctggg gcgccagcca atgacaacaa 1102141 gcaccagaat ggcaatgcag acccatctga aaagatttaa catcatatag ttattttcgc 1102201 cgagacaaaa gagactgaga ttcattttac aagctggata gctgctgatc ccgctggctg 1102261 gcttcataat gaggctcggg tgattgatga gcagcgtcag caggctggat agcgcaatga 1102321 tgcttcgcgc gaggccatat acatttgtcc acgggtttct ttcgtcccat ctggtgatgg 1102381 tctgttttat gttttcgagc atgagatcac aaccttgact atgcttttta cctgataaga 1102441 cgaaggggta tatttagaat agctccaagg aacaatatcc tctttcgtca aatagtagct 1102501 gccacaaagc agcgggcggg gagcgggtgt ttttaattgc acggttttgg ctttgctttt 1102561 gcatgcgccg aggtcctttt ctttacatgc tgtccactgt tccttgccga cttggctgta 1102621 gatcacgccc atttcaacgc cttgtgaccg cccataccga tacaggccga ataggttgtc 1102681 agccctcata ttgggccatc tgaccttggc gctggcattt tcagcctcat ataagccgat 1102741 tgcagtatca cgcggatttt tgctaaaaaa gccccagccc tgagggagga tgctggacat 1102801 gagaaatttg gagtcctttg tcagcggaat cggggttgtc cctaagctgc caataataga 1102861 aaacagaaat agcgaacccc aaaggattga aaaaatgaca aaaaatgata tcgatttctg 1102921 cattcgactg ctccttttaa cctgaagaat cgtttttaca cttttcataa tataaaaaca 1102981 tttatgtaat aaaaaggtta aaaagtatga gaaattccat ttttgttaaa aggaaaaaca 1103041 ggacatttta cactgctata tgtgattgat atatagtgtt tttttcgata tatttaaacc 1103101 atgaaaacga atcaagttaa tgaccgctgg attgttcaat ttcgaaaagg gattttcgag 1103161 ctggccatcc tatcccttct gcgttctaaa ccgatgtacg gttatgagct gacgtcatcc 1103221 ttaaaaacca cctcggcgct ggctatttca gagggagcga tttatccgat tttgaaacgt 1103281 atgaccgaga agggatggat cgaatttttt tgggaagatt cactggacgg cccgaaaaga 1103341 aagtattaca aaatgacgca aaaaggagaa gaaatgttaa aagaacggct ggagaaatac 1103401 ctggaaaccc atcaagcctt actgtcttta tcgggggatt tgctatgaat ggacagctta 1103461 tcattgaccg atacatggag gaactaaatg cagagctggc gaatatgcct gatgtagaga 1103521 gagaaaacgc tatcgacgaa ttaaaggggc atatcaccgc tttcgttcaa gacagaatca 1103581 aagccggcct tagtgaagag gaactgcagg aagctgttga atctgaattt tctcatccga 1103641 aggagcttgc cgaattgatg atgggtgatg ggggagagac gaaaaggagg aggtctttat 1103701 tgggcaaaag ctggatttcg gtccttctca ttgtcacgat tatcgccctg ccgctgctgc 1103761 cgtccgactt cagacatctg ccgctggctg tttatttaat ggtgctcgcc ggatatgtat 1103821 ggaagcggaa aaaattggtg atgtttgcag gtgtcagaaa aaacaaaatg cgctctcaaa 1103881 aggagattgt caagatttcg cgagtcggtg cggtttatct gctgttttta gcagtggtgc 1103941 tccttttgag cccgttcctc aatgcgcttg tcgtcctgct gctgattgca gtaagctgcg 1104001 ccgctttttt tctttttctt aacatcaagt aatcttgtag gaggctgtaa gatggaaatc 1104061 agcatcaatt atctattaat tgtcatcgcg cttttattct ttgtggttgc ctattttgtc 1104121 ggaatcaaaa aacaaacctg gatgttggct gggtttaacg aggcgcgtat acgggataaa 1104181 gatcggctgg ccagaatagc aggctacttt ttcttgaatt ccggtttgtt cattttgctg 1104241 aatagtttta tctcatttca aggtcaggag cagctcatac ctccgcttat actggcatat 1104301 ggagcagggg ttattattta tgtcaataaa aaattagtag agtagaaaaa gaagggcaga 1104361 gcgaaatatc tctgcccttc ttttttggga aaataagaac gaagcaccac atacaagttt 1104421 ttgtattttt gataggatga agaaaaatgg tagattccaa aataggaagg atgtggtgtt 1104481 ttgcgcaact tgaccaagac atctctatta ctggccggct tatgcacagc ggcccaaatg 1104541 gtttttgtaa cacatgcctc agctgaagaa agcatcgaat acgaccatac gtatcaaacc 1104601 ccttcataca tcatcgaaaa gtcaccgcag aagccggtac aaaacacaac ccagaaagaa 1104661 tcgctatttt cctatcttga caagcatcaa acgcagttta agctcaaagg gaatgcgaac 1104721 agccattttc gcgtttcgaa aaccataaag gatccaaaga caaaacaaac gttttttaaa 1104781 ttaacggagg tttacaaagg aattccgatt tacggctttg aacaagcggt cgcgatgaag 1104841 gaaaacaaac aagtgaaaag tttctttgga aaggtgcatc cgcaaatcaa ggacgtctcc 1104901 gtcacaccgt ctatttctga gaaaaaagca atacatacag caaggcgtga gctcgaggct 1104961 tccattggaa aaatcgaata tcttgatggg gaaccaaaag gcgaattata tatctatcca 1105021 cacgacggtg aatatgatct cgcctacctt gtgagactct cgacatctga acctgagcct 1105081 ggctattggc attatttcat cgatgccaaa aacggaaagg tcatcgagtc ctttaatgcc 1105141 attcatgaag cggcaggtac aggaatcggc gtgtcaggtg atgaaaaaag ctttgacgtc 1105201 acagaacaaa atgggcgctt ttatttggct gacgaaacaa ggggaaaagg gatcaataca 1105261 tttgacgcga agaacctgaa cgaaaccttg tttacgcttt tgtctcaact gatcgggtat 1105321 acgggcaaag aaatagtcag cggcacgtcc gtatttaatg aacctgcggc tgtagacgca 1105381 cacgcaaatg cgcaagccgt ttacgattat tacagcaaga catttggccg tgattctttt 1105441 gatcaaaacg gagcaaggat tacgtctacc gtgcatgtcg gcaaacaatg gaacaatgct 1105501 gcgtggaacg gtgtccagat ggtatacggg gatggagacg gttcgaaatt taagccgctg 1105561 tctggatcgc tcgacattgt cgcgcatgaa atcacacacg cagtcacaca gtattccgcc 1105621 ggtcttttat atcaaggaga acccggtgca ttaaatgagt ccatttctga cattatgggc 1105681 gcgatggctg accgtgatga ttgggagatc ggcgaagatg tctatactcc tggtattgca 1105741 ggagattcat tgcggtcatt ggaggaccca tctaagcagg gaaatccaga tcattactcg 1105801 aaccgctaca caggaacaga ggattatggc ggagtccata tcaattcgtc cattcacaat 1105861 aaagcagctt atcttcttgc agaaggaggc gtgcaccacg gtgtacaggt tgaagggatt 1105921 gggcgtgaag caagtgaaca aatttactat cgggctttaa catattatgt aacggcatct 1105981 acagatttca gcatgatgaa gcaagcggcg attgaagctg ccaatgattt atacggtgaa 1106041 ggctcgaagc aatcagcttc agtcgaaaag gcgtatgagg ctgtcggcat tctatgagca 1106101 aacaaaaaca gtcaggacac agagtctgac tgtttttgtt tgctcatttt cttaaaaaga 1106161 atatcgccaa tgtacctgga ccggcatgcg agccgatggc tgaactgatt ggatgcataa 1106221 tgatttcttt cggcttgaac gcttcctcaa tcaggtgttt catatccgtg gctttttctt 1106281 tgttcgcggc gtagctaatc ccgacggttt gattgctcca atcatccccg cgctctttca 1106341 taagctcgat gatccgtttg aaaagtttct tctgtccgcg aattttttcc agaggcacaa 1106401 gcttgccgtc ctccatctga agcagcggtt taatattcaa caggccgccg acaaaagcgg 1106461 acgttttgga tatccggccg cccctcgcga gatatgttaa atcatcaacg gtaaaaatgt 1106521 gttcaagctg gctgcaaaag ttctttacag acgtttcaat ttcttgtatt gtattcccgt 1106581 tgatacagag atcggcagca tgccggacag ccagaccgta tcctaatgaa gcgcatttgg 1106641 aatcaatgac ccgcaaatcg aaatcgggga attcctcctt cacttcattg gcgatcatta 1106701 cagctgtctg atacgtgccg gagagacctg aggaaaaggc aatgtaaaga gcgggatcac 1106761 ctgtttcggc atattgcaaa aacacatttt taatcgtttg cggtgaggct tgggacgtct 1106821 taggcgtttc tccattttgc atcgcttcaa atatttgatc cgcatgaatt gtgactgcat 1106881 cttcgaattc tttatcgccg agagaaaccc tgagcggaat aaagccaatg cctttttctt 1106941 caaaataaga acgaggcaaa tcagtggcgc tgtcagcgat gagatgaact gtcatattgc 1107001 ttcccttctt tccgttatcg ctcgttatca tgagagttaa gccaactata tcatattaat 1107061 ttgccaaaat cgtgttcaaa tatttgtttt aagggaaaac ataataaaga agaaagagcg 1107121 gaggaacatg ccatggtact agatcaaaca aaaaaattac tcatcgtcat catcggcgct 1107181 ttactcaatg ctgccgggct gaacttattt ttgatacctg cagatgtata tgccagcgga 1107241 tttacaggtg ttgcccagct tttatcaagc gtcgttgatc aatatgcccc cttttacata 1107301 tcgacgggaa cgctcttgtt cctcttaaac attccggtcg gtattttagg atggctgaag 1107361 gtcggcaaat cgtttacagt gtacagcatt ttaagtgtcg cactcactac tctgtttatg 1107421 gggatcctgc cggaaacaag cctgtcacat gacattttgc tgaacgcggt gttcggcggc 1107481 gtcatttccg cagtcggtat cggcttaaca ttaaaatacg gagcttcgac aggcgggctt 1107541 gatatcgtcg ccatggtact tgcaaagtgg aaggataaac ccgtcggcac gtatttcttc 1107601 attctgaacg ggattatcat cttgacggca ggattattgc aaggttggga gaaagcatta 1107661 tataccctgg ttacactata tgtgacaacg agggtgatcg acgccattca cactcgccac 1107721 atgaagctta cggcaatgat tgtgacgaaa aaagcggacg aaatcaagga agccatttac 1107781 ggaaaaatgg tgcgcggcat cacaactgtt ccggcaaaag gagcatttac gaacgaacag 1107841 aaagaaatga tgattatcgt catcacgagg tatgaactgt acgatttaga aaagatcgtc 1107901 aaagaagttg atccaaaagc atttacgaac atcgttcaaa cgacagggat ttttggtttc 1107961 tttagaaaag actgacgaaa gcaggtggaa gtcgtgaaac ggctgcttgt gatgctcctc 1108021 cccgtgctgc ttttgatagg ctgcgggaaa gatgagcaga cagaacccga taaggaggta 1108081 tcaggcggaa tggagaatca agaggttgtt ttatctattg acgcaattca ggagcctgaa 1108141 caaatcaagt ttaacatgtc gctgaagaac caaagcgaac gtgctattga gtttcaattc 1108201 agcacagggc aaaaatttga acttgtcgtg tatgattctg agcacaaaga aagataccgt 1108261 tattcgaaag aaaaaatgtt tacgcaggct tttcaaaacc tgacgcttga atctggagaa 1108321 acatatgatt tctctgatgt gtggaaggaa gtccctgagc ccggaaccta tgaggtaaag 1108381 gtgacattta agggcagggc ggaaaatctc aagcaggttc aggctgttca gcagtttgaa 1108441 gtcaaataag aggctatggc gagtcgccat agcctttttt tattgcagtt tgtccagctg 1108501 attttgaaat tgatgcaact gttgacgttc cgcatctgtc gaattggcat acgcagaaga 1108561 tacagcattt ttggctctca gaatcgcttg ctcctgatcg ccttcctcaa agccgtttgt 1108621 caccatgacc gcctgttgaa caaatgattt tgcctgctga aacagttcat ttctcattta 1108681 atattcatac tgcctttcag ccgagtctcg tgccgcggca tgctggtgag cttcttctaa 1108741 agtagaccga tatggaaatc ttgcggcgtg tagcccgatg gagtctttac cctgctgaat 1108801 aaaccttctg gatttgcttc gtttacccat tttgagactg cccccttcca tactttgacg 1108861 agatgagtcg tcttcaatag tatggtgggg taaagtaagg tttatgagtg ggaaaaatta 1108921 atacggacct tctttaaagt gagaaatatt ctttcaaaaa ccttgccacg ccgtcctctt 1108981 catttgtggc cgtagttcgg ttggcaatct gcttgaccgc gtcaattcca tttcccattg 1109041 caacgccgca gcctgcaaat tcaagcattt ccaaatcgtt atcctcatct ccaaaagcaa 1109101 tgatccgctc cctcggcacg ccgtaataat cgctgatttt ctgcaggccg accgctttat 1109161 tcatgccgct tttgataatt tcaatgacat gccaaggagc ggcccatctt ctatggtcga 1109221 tcacctcggc atgcacatcc gataaatatg agcgtattgc cggcacatcc tcttcctttg 1109281 catgtatgag tacggacgtc acatcttcac cgagattttc ccgcaagtct ccgaccgtta 1109341 catttgttgt gttcatgtta aaggcatcta tcaggtgctc atcatggtaa tgaaagtata 1109401 cgtcgtcaat cacttcagca agcacgttat gtacgttgta gctctcgctg atatccacga 1109461 gctgtttgac aacatcaagc ggcagtgacg tatgataccg tccccagctg tcgtcttgcg 1109521 gatgatggac aaatgctccg ttaaaattga caattggcgt tgtcagctcc atctgctggt 1109581 agtacatgga acttgaacga tacggacggc ctgttgagat gcagacataa tgcccgtcat 1109641 cttttaggcg ctgtatcgta tgaagggtgt tttcagatat ggttttatca tcctttaata 1109701 atgttccatc taaatctaat gcgattaaat agggttttgt ctccatgaaa agctccttta 1109761 accttagatt ttgcttgttt tgccttactt acagtgtagc tttttaccat ctttattgtc 1109821 tacatgttac acttatgatt atggttatcc taaggagggg cacattgtga tacaaattga 1109881 gaatcaaacc gtttccggta ttccgttttt acatattgta aaggaagaga acaggcaccg 1109941 cgctgttcct ctcgtgatct ttatacatgg ttttacaagc gcgaaggaac acaaccttca 1110001 tattgcttat ctgcttgcgg agaagggttt tagagccgtt ctgccggagg ctttgcacca 1110061 tggggaacgg ggagaagaaa tggctgttga agagctggcg gggcattttt gggatatcgt 1110121 cctcaacgag attgaagaga tcggcgtact taaaaaccat tttgaaaaag agggcctgat 1110181 agacggcggc cgcatcggtc tcgcaggcac gtcaatgggc ggcatcacaa cgcttggcgc 1110241 tttgactgca tatgattgga taaaagccgg cgtcagcctg atgggaagcc cgaattacgt 1110301 ggagctgttt cagcagcaga ttgaccatat tcaatctcag ggcattgaaa tcgatgtgcc 1110361 ggaagagaag gtacagcagc tgatgaaacg tctcgagttg cgggatctca gccttcagcc 1110421 ggagaaactg caacagcgcc cgcttttatt ttggcacggc gcaaaagata aagttgtgcc 1110481 ttacgcgccg acccggaaat tttatgacac gattaaatcc cattacagcg agcagccgga 1110541 acgcctgcaa tttatcggag atgaaaacgc tgaccataaa gtcccgcggg cagctgtgtt 1110601 aaaaacgatt gaatggtttg aaacgtactt ataaagcact aagttattaa caagagctga 1110661 atttacgtta tactgtagaa aaaaggagtg agggaacgtg gaagaagcat taaaagaaaa 1110721 catcatgggc gccctggaac aggttgtcga tcctgagctt ggcgttgata tcgtgaacct 1110781 cggcttggta tatgacgttg atatggatga agatggcttg acgcacatca ccatgacgct 1110841 aacatcaatg ggatgccctt tagcgccgat tatcgtggat gaggtgaaaa aagcattagc 1110901 ggaccttcct gaagtgaaag acacagaggt tcacattgta tggaatccgc cttggactag 1110961 ggataaaatg tccagatacg caaaaattgc gcttggcatt caataaaaca aaaaaggaca 1111021 gcctgacatg tgaggctgtc cttttttaca gctgaaagga gtgaaaggaa atgatgtacc 1111081 tgctggcagt tttatgcccg ccgcttgctg ttttgttttc gggaaaaccg tttcaggcct 1111141 tgctgaatct catattgacc tgtatctttt ggctgccggg cgcgattcac gcctgcttta 1111201 tcgtcgccga ccgccgtgcc gaaaaacggg caagaagata atttggaaaa atgaggacgc 1111261 agtcatggta taatggtcat aaaaacagca gggagagcac tatgaaaaag aaattgcttg 1111321 cattcgcgct ttgtactggc gcgtatgcgg ccctgtttgc gtactctgtg aactcagagc 1111381 aaaaaacagc cacaagcgag atgacggatg tcagccgcct gatgcctgta aaaataaagc 1111441 agacagtgaa agggcaggaa gaggaaatgc tcattgacac agtcaaagag gcaaatcgaa 1111501 aaaacataaa aatttcaatc gccggggccc agcactccat gggcggccat acatattatg 1111561 aggacggcat cgttctcgac atgacgggct acaacaaaat cctgtcactc gatcaagaga 1111621 agaaaaccat cagggtgcaa agcggtgcaa cgtggaatga tatccagaaa tacgtgaatc 1111681 catacggact cgcggtaaaa gtcatgcagt cacaaaacat ttttacaatc ggcggatctc 1111741 tcagcgcaaa tgcacacgga cgtgatattc gctacggctc gctaattgat acagtcaaat 1111801 cattccggct tttaaaagct gacgggatga ttatcactgt cactccaaaa gatgatttgt 1111861 ttacggcggt catcggaggg tacggccttt ttggcgtgat tcttgatgta acgcttgagc 1111921 tgacagatga tgagctgtat gtcatgaaga cagaaaaaat gaattacagc acatactcag 1111981 actatttttc aaagcatgta aaaggaaatc cagatgtccg aatgcatctg gcgcgaattt 1112041 caacagcgaa aaaaggattt ctgaaagaca tgtatgtcac gaattacgta ttggctaatc 1112101 atcaggatca gctgtcctca tacagcgaac ttaaagaaga cgagtatacg ggagccacaa 1112161 agtttgcact cggcttgtca agacggtatg aatgggggag gaattggctg tgggacacac 1112221 agcaatccta tttcctgagc cagaacggca cagagatttc acgcaataac gtcatgcggt 1112281 ccgaatcaaa gtttcttgag tatgaaaaca atgacaacac agatgttttg caagaatact 1112341 ttgtgcccgt gaaggagtat gggtcctata ttgatgacct gagacaaacg ctgtcggacg 1112401 aagatctgaa cctgctgaac attacgatcc gctacgtgca gaaaaatgaa aaggccgacc 1112461 tttcctatgc gaaggacgat atgttttcgc tcgtactatt aataaacgag ggcttttcaa 1112521 aagaagacca ggcagatacc gcccgaatca tcaggcgcat gacagacgtt gccatcaagc 1112581 acggcggcag ctattatctg ccttatatga cctaccagac aaaagcgcaa atgagacagg 1112641 catatccgaa aagtgaagcg ttttttcaga aaaaacgaac ctatgacccg gatgagcgct 1112701 ttatgaatta cttttatcag aggtataaat aatggggaaa aacaaattaa aatggctgac 1112761 attatcacaa agcagcgtgt ttttcgcaag cagcttaatc tttccgtttt atattctgtt 1112821 tgtgaaaaat atcggctcaa gctacacaca gttcggtttt tcctacggat tgttcgggtt 1112881 gagcggagcg cttatttacc cgctcctcgg acggctgtct gaaaggtttg acagccgtta 1112941 ttttctgctt ctgaactcgt gggggatggc tgttctgctt ttatatgtcc cgcatatcgg 1113001 aagcgtcgtt caagtgtata tcgtccaagt gctgttaggg ctctttggag cgatgcaaaa 1113061 gcatggagaa aaagtgctga tcgctaattt tacagacagt ggagagcgtg gaaagaagat 1113121 cgggaattac catttttgga cagctgtctt ttcagcagca gccattatgc tcgggggctt 1113181 tctcgctgac tttttcacag tgcaaatgat tttttatgca agctctattc tatatttttt 1113241 gagtggattg atgatgatga aaacaggctg acgcggtcag cctgtttttt tatgcggctg 1113301 aaatgcggca ccgcatcaac gtttttgtgc tggagtcgtg ctgatttttt ttgagcggaa 1113361 ttcccattga acagaaaatt tataaatgaa taaaaatatt aaatatacga ttgaattaat 1113421 ttttattcat gttataatgt taaataattt cacaaagacc aagagggtga acttgttttg 1113481 aaaataggaa ttgtaggtgc tacaggatat ggaggcaccg aacttgtcag gattctttcg 1113541 catcatcctc atgcagagga atgcatactt tattcatcca gcggagaagg gaatgtctat 1113601 agcgagggtt atcctcatct taccggctta gcggatcagc agctgaagcc gattgatatg 1113661 aatacgatca aacacgaaat agatatcatg tttctcgctg cgccgcccgg agtatcaagt 1113721 gaattgactc caaagctggc agacgcggga attacggtta ttgatctgtc aggtgatctg 1113781 aggataaaag aaccggctga atatgaaaaa tggtataaac ggacagcggc accgaaggcg 1113841 gtgattcaag aggcggtata cggtctggca gaactgaatc aactgcaaat tcaacaggcg 1113901 aaactcattg ccaatccagg ctgttttcca acagctgttt tgcttggcct cgcgccattg 1113961 gctcaaaaga aactgctcga tgaatctttc gttatcgttg acgcgaagac cggtgtttcc 1114021 ggagcgggaa gaaaagcatc catgggaact catttttctg agctgaacga caattttaaa 1114081 atttataaag tcaatgaaca tcagcacacg ccggaaattg agcaggcgct gaatgaatgg 1114141 cagccaggtc tcgggcccat tacattttcg gctcacttgg ttccgatgac aaggggcatc 1114201 atggcgacga tgtataccag attaacctgt gacctaaccg cagatgacct gcatgattta 1114261 tattcggaat tttaccaaga ttcatatttt gtgagagtga ggccaaaagg tcagtacccg 1114321 caaacgaaag aagtgtacgg cagcaatttc tgtgatatcg ccgtgaccct cgatgagaga 1114381 acgaacagag tcacgatcgt ctcggtaatc gataatttaa tgaagggtgc cgccggtcag 1114441 gcagtgcaaa actttaattt gatgaatggc tggaatgaag aaactggact caccatcacg 1114501 ccaatttatc catagaacgg gagagaatcg aaccatgatt cagttaagtg aagatcaaat 1114561 tgtaaaagta acaggtgatg tatcctcgcc aaaagggttt caggcaaagg gtgtgcattg 1114621 cggactgcgc tactcgaaaa aagacctcgg cgtcattatc agcgagacac cggccgtgag 1114681 tgcagcagtt tatacccaaa gccactttca ggctgctccg atcaaagtga cacaagacag 1114741 cttaaagcac ggaccgacac tgaaagccgt catcgtcaac agcgccattg ccaacgcctg 1114801 cacgggagaa cagggcttaa aggacgcata cacaatgcgg gagagctttg cttcacagct 1114861 tggcattgag ccggagcttg tcgctgtttc atcaacgggt gtcatcggcg agcatttaga 1114921 catggaaaaa atccacgcgg ggatcgaact gctgaaagaa acacctgcgg gatcaggcga 1114981 ttttgaggaa gcgattttaa caactgatac ggtgatcaag cagacgtgct atgaactggc 1115041 aatcggcggc aaaacagtca cgatcggcgg agcggccaaa ggctctggga tgatacaccc 1115101 gaacatggcc acgatgctgg gatttgtgac aactgacgcg gcaatcgaag aaaaagcgct 1115161 gcaaaaggcg cttcgggaaa tcactgacgt ttcatttaac caaatcacag ttgacggaga 1115221 aacatccacg aacgacatgg tattagttat ggcgaatggc tgcgccgaaa acgagtgcct 1115281 gacagaagac catccagact ggccggtctt taaaaaagcg ctcttgctca cttgtgagga 1115341 tctagctaaa gagattgcca gagacggaga aggcgcgaca aaactaattg aagcccaagt 1115401 acagggagcg aaaaacaatc ttgatgcaaa cgtcattgcc aaaaagattg tcggctcaaa 1115461 tcttgtaaaa acggcagtat acggaacaga tgccaactgg gggcggatca tcggagccat 1115521 cggacactcc gcagcacagg tgacggcaga agaagtagag gtttatcttg gcggccaatg 1115581 cctgtttaag aataacgaac ctcagccatt ctctgaatct atcgccaagg aataccttga 1115641 aggagatgaa atcaccattg tcatcaagat ggctgaaggg gacggaaacg ggagagcgtg 1115701 gggctgtgac ctgacctatg actatatcaa aattaacgcg agctatcgca cgtaataaag 1115761 gggagcgaaa tgaagaaaac aatcgttttt aaatgcgggg gaagcgtcat ccgtgagctg 1115821 tcggaggaat tttatcaaaa tctgaaagag ctgagggcgt caggctggaa gctggcaatc 1115881 gtacatggcg ggggaccgga aatcacaaat atgctgaaac ggttaaatat caagacagag 1115941 ttttcgggcg gacagaggaa aacaacgaag ccggtgctgg aagtggcgga aatggtttta 1116001 tccggttctg tcaataaatt tttcgttgct gagcttgcca aacacggact gcgagccgcg 1116061 ggcatttctg gtaaggatgg cggtcttttg gaggctgatt atctagatcc ggaaacatac 1116121 ggagaagtgg gagaaatcaa aaaagtcgat gcgtccatgg tgaacgcgct gatggaaaat 1116181 ggcatcatcc ccgttattgc gccgctgtct atgacaagcg actgcaaaac gctgaatgta 1116241 aatgctgatc tggctgcttc agcagtcgcc ggagcgcttg aagccgataa gctgatgttc 1116301 gtcacggatg tcgatggaat catgaaggaa aagcagcgtc tggacgtcct gacccctaag 1116361 gagattcaga tgctgatcaa gcaggaagtg atcacaggag ggatgatccc gaaggtcaat 1116421 tcagccttgt cagctttatc agatcaggtg tctgaagtca tgatcgtaaa cggtaaagga 1116481 tcattcttcg cagaacaaac ctttcaaggg acaaaaattg tcaaagcaaa ggaggctgtt 1116541 tcatgagcag cttgtttcaa acctacggcc gttgggatat tgacatcaaa aaagcaaagg 1116601 gaacgtacgt tgaggatcaa aacggcaaaa cgtaccttga tttcattcag gggattgcgg 1116661 tatcaaatct aggacactgc catgaagcgg tgacagaggc agtcaaaaaa cagcttgaca 1116721 gcgtatggca cgtatccaac ctgtttcaaa acagtctcca agagcaagcg gcgcagaagc 1116781 tggcagcgca tagtgcggga gatcttgtct ttttctgcaa cagcggcgcg gaggcgaatg 1116841 aaggtgcgat aaagcttgcc agaaaagcaa ctggaaaaac aaaaatcatc acttttcttc 1116901 agtcgttcca tggccgcacg tatgcaggga tggctgcgac cggacaggat aaaatcaaaa 1116961 caggcttcgg cccgatgctt ggaggctttc actacctgcc atacaatgat ccttctgctt 1117021 ttaaagctct tggggaggaa ggcgatattg ccgcggtgat gcttgaaaca gtgcagggag 1117081 aaggaggagt caatccggcg agtgctgaat ttttatcagc cgtacagtcg ttttgcaagg 1117141 aaaagcaagc ccttctcatt attgatgaaa tccagaccgg catcggacgg acgggaaaag 1117201 gcttcgcata tgagcacttc ggactctcac cggatatcat cacagtcgcc aaaggattgg 1117261 gaaacggctt tccggtcggc gctgtcatcg gaaagaaaca gcttggagaa gcgtttaccc 1117321 ctggttctca cggaacgact ttcggaggaa acatgctggc gatggctgct gtgaatgcca 1117381 cattgcaaat tgtattccag cctgactttt tgcaagaggc tgctgacaaa ggggcgtttt 1117441 taaaagaaca gcttgaggca gagctaaaga gcccttttgt taaacaaatc cgaggtaaag 1117501 gattaatgct tggaattgag tgtgatggcc cggttgctga cattattgct gaattgcaga 1117561 cattaggctt gcttgtattg ccggccggcc cgaacgtgat tcggctgctg ccgccgctca 1117621 ccgtgactaa ggatgaaata gcagaagccg tcagcaagct gaaacaggca atcgctcatc 1117681 attccgctgt aaaccagtga ttttttttcg atataaaggc ataaaaattc atttttataa 1117741 ttaattattc atcaagaggt gggctgttag atggaaggtt atttagtgtt agaagatggg 1117801 acatcgttca gcggcgagct ggacggtcat gaaaactgca cgggagaagc tgtttttttc 1117861 acaggaatga caggctacca ggaagtgctg acagatccat catataaggg acagattatt 1117921 gtatttacct acccgctgat tggcaactac ggcataaatg aaaaggattt tgaaagcaag 1117981 aaaccgcaag taaaagccgc ggttgtctat gaggcgtgtg atcacttttc tcattatgaa 1118041 gcggtataca gcctcaagga gtatctacag aaatggaata ttccgctgtt aacccatgtt 1118101 gatacgaggg ctgtcgtgaa gaaaatccgg gcaaacggga cgatgggtgc gacagtcaca 1118161 gcctctaaag aaggagctga gattgccctt caaccagaga atgtggcaga gcaggcttcc 1118221 gcccaggaaa tcagcacatt cggcgacggg aataaacata tcgctctcat tgattttggc 1118281 tataaaaagt caatcgcatc atcacttgtc aaacgaggct gcaaggttac cgtggtgcca 1118341 taccagcaaa tggaggccgt atacaacatc aaacccgatg ggctatcgaa cggacctgga 1118401 gatccgaaag ccattcagcc atatttagga aagatcaaaa gcatcatcag ccgctttccg 1118461 actctaggca tttgtctcgg acatcagctg atcgcgctcg cgtttggagg gaatactttt 1118521 aagctgccat tcgggcacag gggagctaat catccggtca tcgaccgtaa gacgaaacgg 1118581 gtctttatga caagccaaaa ccacagctat gtggttgatg aacagtcgat taatgaagaa 1118641 gagctcacca tcaggtttca tcatgtcaat gatacgtcag ttgaagggct tgcccataaa 1118701 aaactgcctg tcatgagtgt tcaattccac ccggaagccc atcccggacc tgcggaaagc 1118761 gaatggattt ttgatgatta tctaaagaat gtgataccag caaggagaga aatcgcgcat 1118821 gcctaaagac accagtattt caagcatatt agtaattggc tcaggcccga tcatcatcgg 1118881 gcaggcggca gaatttgatt attcaggcac tcaagggtgc atcgcgctga aggaggaggg 1118941 ctaccgggta attctcgtca acagcaatcc ggcgacaatt atgactgatg aagccttcgc 1119001 tgatgaaatt tattttgagc ctctgacagc agaaagcctg acagccatca ttaagaaaga 1119061 acggcctgat gggcttcttg ccaatttagg cggtcagacc gcgttgaatt tagcggtgga 1119121 gcttgaagaa acgggtgttt taaaagagca cggcgtcaaa ctcctcggca catccgttga 1119181 aacgatacaa aaaggagagg accgggaaaa attccgttcg ttaatgaatg aattaaaaca 1119241 gcctgtgccg gagagtgaaa ttgttgataa cgaggccgat gccctccatt ttgcggaatc 1119301 catcggtttt cctgttatta tcagaccagc ttacacatta ggcggaaagg gcggaggaat 1119361 cgcccctgat aaagaagcct ttacagctat gattaagcag gcgctattag caagcccgat 1119421 caatcaatgc cttgtcgaaa aaagcattgc cggctttaaa gaaattgaat atgaagtcat 1119481 gcgtgacagc aataacacat gcattaccgt ctgcaatatg gaaaatatcg atccggtcgg 1119541 cgtgcataca ggtgactcta tcgttgtggc gccgtcacaa acattgacag acgaagacta 1119601 tcaaatgctg cggacagcaa gtctgacgat catctcagca cttgatgttg taggcggctg 1119661 caacattcaa ttcgcgcttg atccattcag caagcaatat tacgtcattg aagtgaatcc 1119721 gcgtgtaagc cggtcatcgg ctctcgcatc taaagcgacc ggttatccga ttgcgaagat 1119781 ggccgcgaaa ctggcagtcg gatacactct tgacgagctg aaaaatccgc tcacaggctc 1119841 gacttacgca agctttgaac cggcactgga ttatgtgatc gtcaaatttc cgcgctggcc 1119901 gtttgataaa ttcaaaaacg cagaccgcaa gcttggcaca aaaatgaaag ccaccggtga 1119961 agtgatggcg attgaacgga atttagaagc ggcgatacaa aaggcagccg cgtcgcttga 1120021 attaaaaaat atcgggacac accttccaga gctcagcggg ttgtcaattg atacgctatg 1120081 ggatttggca atcactccgg atgaccgcag atttttcgtt gtcatggagc tgttgagccg 1120141 cagcgtctcg attgatgaca tccatgaaaa aacaaaaatt gatccgtttt tccttcatac 1120201 ctttgacaac atcatcaaat tggaaaaccg cctgatggaa gcagggagcg atctctcttt 1120261 tgaattattg aagaaagcaa aggaaaaggg attctcagac gcaacgattg cctcgctgat 1120321 cagcaaaaca gaagaagagg tgcgcgcgct tcgcaaggag atgggcatta cgccttcctt 1120381 taaaatcgta gatacatgcg cggcagagtt tgatgcgaaa acaaactatt tttactccac 1120441 atatttcgga gagaccgatg gagacatcag ccgcaaagag aaaaaacgcg cgctcattat 1120501 cggatcaggc ccgattcgga tcggccaagg cgttgaattt gattacagtg ctgttcacgg 1120561 tgtgctgaca ctgcaagagc ttgggttcga aaccatcatg attaacaata acccggaaac 1120621 tgtcagcacc gattatgaaa ttgcggaccg cctgtatttt gaaccgatga caacggagca 1120681 tattgtaaac gtggcggagc aggaaaatat tgattttgca attgtgcaat ttggcggtca 1120741 aactgcaatc aatgctgctg aagcgctcga aaaagccggc attactcttc ttggcacatc 1120801 atttcaaacg ctcgacgtgt tagaggatcg ggatcaattt tatcagcttc ttgacgagct 1120861 gggattgaag cacgcaaaag gagaaattgc ttatacaaaa gaagaagccg cttcaaaagc 1120921 gagtgagatc ggctatccgg tgttaatccg cccatcttac gttatcggcg gaatgggcat 1120981 gatcattgtt gactcgcaag cccagctttc tcagctgctg aatgatgagg acagcatgcc 1121041 atacccgatt ttaattgatc agtatgtgtc tggaaaggaa gtcgaaattg atttgatttc 1121101 cgacggcgag gaagtcttta tcccgacata taccgagcat attgaacggg caggtgtcca 1121161 ttcaggggac agttttgcca ttcttcccgg accgtccatc acgagcgggc tgcagcaggg 1121221 catgaaagat gcggcacaaa aaattgcccg aaaactttca tttaaaggca tcatgaacat 1121281 tcaatttgtg atcgacaatg gaaacatact cgttcttgaa gtgaatccga gagcgagccg 1121341 cacggttcct gtcgtcagca aagtaatggg cgttccgatg attccgctcg ccacacgtct 1121401 gctggcggga gcgtccttaa aagatctaaa tccggcagtt caaaatcatc atggagttgc 1121461 cgtgaagttc cctgtttttt cttctcatgc gatccaggat gtggatgtca agcttggacc 1121521 ggaaatgaaa tcaacgggag aaggcatgtg tgtcgcatat gattctaaca gcgccttgaa 1121581 aaaaatctat acaagagtct ggagtcaaaa aggaagcatt tatttgcaaa acgttccgga 1121641 agatgtgaag gagttagcag aaaacgcagg ttttacaata catgaaggaa catttgcctc 1121701 atggatggaa caggaaggaa actcgctcca cattaatctg agcggttctg aagaagcacg 1121761 caaagaacgt ttggaagcca tgacgcacgg catccccgtc tttacagaag aagaaactgt 1121821 gcgggcgttt ttacaaagcg gttcaggcca tccgcagcct gtatctctca aagacctcta 1121881 taaaaaggaa gtggcatcat gcacacagtg acgcaaacca gtttatacgg aaaagattta 1121941 ttaacgttaa aggaccttag tgaagaagat ataaacgcct tgctcgcaga agccggtgag 1122001 ctgaaacaaa acaaaattca gcctatattc catggcaaaa ccttggcgat gatttttgaa 1122061 aaatcatcaa cgcggacccg tgtttcattt gaagcgggca tggcgcagct gggcgggagc 1122121 gccctctttc taagccagaa agatctgcag ctggggcgcg gtgagactgt cgctgatacg 1122181 gcaaaagtgc tgtcaggcta tgtggatgcc atcatgatcc ggacctttga acatgaaaag 1122241 gtggaggaac ttgccaaaga agctgacatt ccggtgatca atggacttac cgataaatac 1122301 cacccatgcc aggcgctggc ggatctcttg acgattaagg agataaaagg gaagcttaaa 1122361 ggcgtaaaag tcgcgtacat cggtgacgga aataacgtgg cgcactcctt gatgatcggc 1122421 tgcgcgaaaa tgggctgtga tatctcgatc gcttcaccaa agggatatga agtgttagat 1122481 gaagcagctg aagcggcaaa gacatatgca cttcaatccg gctcttctgt cacgctgaca 1122541 gatgatccga ttgaagctgt aaaagacgcg gacgtgattt attctgatgt gtttacaagc 1122601 atggggcagg aagcggaaga gcaagaacgt cttgctgtct ttgcgcctta tcaggtgaat 1122661 gcggcgctgg tcagccatgc caagcctgac tatacatttt tacattgtct ccctgcgcat 1122721 cgcgaggaag aagtgactgc ggagattatt gacgggccga actctgcagt gttccagcag 1122781 gcggaaaacc gtcttcatgt gcaaaaagca ctgctgaagg ccattttata taaaggggaa 1122841 tcatcaaaaa actgctgagc caaactcagc agtttttttg atggcaacat attcacagcc 1122901 gcttaggcgc atactacagc aaaaaggaaa aggaggaaaa acagtgggac agcagcacca 1122961 attccggccc ggacagaaag cgcctaataa cggtgtctac gtagaaatcg gcgagacagg 1123021 gagcatggtt aaaaaccctc aaaaggtcca tctgtcagca ggggaaatgt tccccgaaac 1123081 atcaaaccac aaccggctgt ggacctacaa aagaaagccg tgaccactaa aaaacccaaa 1123141 acaataaatg ttttgggttt ttggcttttt aatgctggct tgcatttttg ttcataggca 1123201 tgatttctgc taaaaccatg attaagacat acagtacaac agcaatgaca gatgatgttt 1123261 tgaaattata cgtaacgctg ttcatgcttg caaccaagta gcatgccata tgtgataaaa 1123321 ggaacgtcca aataaaggca ataatatatc gcacgtttcc acctcgtcct tctcattcta 1123381 ttctaaaagt tatcatacca tacaaaaagc gaagggggaa tccaatttta gcagaaagtg 1123441 aggtgacaaa agagtctgat tcgtcacact ttaatggtaa aatataaaac gtcaatcagt 1123501 ataatagcca aaaatgtaaa aggctaggac tttaccttat tcgtttcttt tctatttaca 1123561 taagatagcg tgagatgaag tgtgaaagga ggcgggcaag cgatgggaat aacggaaaga 1123621 tactttcaac tgggaacgga gcataatgtc attcatctgc cctatcgccc gaacggcttc 1123681 ggcatcttta tcttggggga cagaacccac tttgtcggac atgattcaag cttttggcag 1123741 cagcattatg gcagaaatca gcttctgagc atgttgatga atgaaggata cactcttttt 1123801 aacagcaatc tgttcggaag gcattggggg gcggaaaaag cagtcaccta tgccaaacag 1123861 ctgatacatt ctgtgctgaa gcaggaaatc ctcaatccga agattcatat tttagcagaa 1123921 ggcatgggtg ctctcgtggc cgatgaactg cttcgttttt ccccggatca tatccgctca 1123981 gccgcaatgt tgaatccttg tctcgatctt caggcacatt atgaatcgga aaaagaaaat 1124041 aaatttttct ataagcaatt tttgaaagaa gtatcgaaaa gctacggaat ttctgaaaaa 1124101 gaagcggaag cgattcgtta taaaacaatt caaagctacc cgagcggcgt accggttcat 1124161 atatggcagc gtatgaccgg agctccatat ccctacagcg tacatgcgga agttttcaag 1124221 gaaaaacagc aaaagcaagg ctcaccggtc gacatgacat ttcatttatt tgagcatcca 1124281 agcagaattt atgcatcaat ttgcaaattc tttcatagtc atgaaaaaga attatagaga 1124341 atataatgac aacagccttc tcttttgcgg aggctgtttt gttttgggaa atgaaaaacc 1124401 ggaagggcgg cagatgcaat ggaatcaacg ctgattgtag gtgcggacga atttttcggc 1124461 ctttcattat gtgagcgaat gatggatgaa ggcatacatg ttgacgttgt tctggcggaa 1124521 acagaagata aaatgagaca aatgtactta gaagaaagac tcatgtggct tgggagaaat 1124581 gaactctttc gccagcttga acacattgga gaccaaaatt atgatacaat ttgtatccag 1124641 ttcggaagtt ttttgccttt agaccaatat gattctcctt atattttagt atatgaagaa 1124701 gaccgaaaag aatgggataa acgtgaaaaa acaggctcgg aaaaaaccgt gatcctgccg 1124761 aaaatgtacg ggccatggaa agaagaaaca gaggaagacg gctattacac aaacgacgtg 1124821 gctgacgagt tgctgagatt cctgttagaa ccaagccgtc atagcaaaga tcagcttttt 1124881 gaattgcaag tcacagagaa aacctcaaaa gaagaagcaa aaacaaaaat tatcgagtgg 1124941 aaaagacaat tttcatcaat tttcgacaaa tattaagaaa aaccttccat gtttcgagtt 1125001 ttctagatac aataaacgta taaaaataat acatgttata gcttgtcaaa aggagttgaa 1125061 catgacttga tcacaaggct tgtcatgatc ttttctgtcc tccttttatt gagtggatgt 1125121 ggacaaactc cgttcaaagg aaaaattgag aaggtcggca tgctctttcc tgatacgatt 1125181 aatgacctcg tatggggcac aaaagggtat aaaggattac tgaatataca atccaaatac 1125241 aatgtggacg tctattataa agaaggcgtt aaaacagaag aagatatcat aaatgcgatt 1125301 gaggattttc ataagagggg cgtcaatctg ctctacggcc atgggagtga atatgctgag 1125361 gtgtttaact tggtcggcga agattatcca gatatggaat tcgtcatttc caatgcgaaa 1125421 gcgaaagctg ataatgtaac aagtgtccat tttagcgggg aagcaatggg cttttttgga 1125481 ggaatgactg ctgcccatat gtcgaaaacg aatcaggtcg gtgtaattgc ttcctttacg 1125541 tggcagcctg aggttgacgg ttttatcaaa ggggccaagt atgaaaatcc ggatatagag 1125601 gtaaatacga aatatacgga tcattgggat gatgatacaa cagcagtaaa gctttatcag 1125661 aaaatgaaga acgaaggcgc ggatgttgtg tatcccgccg gagacgggta taatgttcct 1125721 gttattcagc aaatcaaaaa agacggtctt tatgccatag gctacgtcac agatcaatcg 1125781 gatctgggcg agaataccgt attaaccagc acggtgcaaa atgtggacaa ggcctatgaa 1125841 atcattgctg aacaatttaa taaaggcacc cttgagggcg gcgatcatta ctacgacctg 1125901 aacacgggag tcgttgagat gggaacattc agcccgctcg tcgatcaaga ctttcagcaa 1125961 agaatcgcca agctgatcaa aacatacaac aaaacaggcg agctgccaaa aaacgagtaa 1126021 tggagtgacg tcacatgcag cacgaaaaat cacttgaatt cttgcaaatt gccatgaaat 1126081 atctccctga agcgaaagaa cagcttgaga aatcaggcat tgagctctca atggaggcca 1126141 tccagccgtt tatgaatcta tttacaacgg taatggcgga agcttatgag cttggcaagt 1126201 ctgacgctaa atctgaaaca gaataagaag aagccacttt tttgaaagtg gcttttcaca 1126261 tgattttctt tttaatagcg gagagcatgg gcgcaagctc ctttaaagcg ggcttgattt 1126321 gatcaagaga gttcataatt gaaccgattt ggtccataat atgcatgtaa ttaatcgtct 1126381 cttcgtcgtt tgtctgagaa acctgagaaa cttcctcttg ctgttcctcc tccttctctt 1126441 ctgttggttt tgctgcatcg ccgaacatca ttcttgaaaa cacatccaac tgcatacgcc 1126501 tcctttccat ataccatact ctatgagtaa gatgaactga tagtttagac gaatatattg 1126561 ccatgtgaaa aaaaatagga tagaattagt acctgatact aataattgat cacaacctga 1126621 ttgatcttct aaatttaaga tataaaggag tcttccctaa tgaaagctgg aatacttggt 1126681 gttggacgtt acattcctga gaaggtttta acaaatcatg atcttgaaaa aatggttgaa 1126741 acttctgacg agtggattcg tacaagaaca ggaatagaag aaagaagaat cgcagcagat 1126801 gatgtgtttt catcacatat ggctgttgca gcagcgaaaa atgcgctgga acaagctgaa 1126861 gtggctgctg aggatctgga tatgatcttg gttgcaactg ttacacctga tcagtcattc 1126921 cctacggtct cttgtatgat tcaagaacaa ctcggcgcga agaaagcgtg tgctatggat 1126981 atcagcgcgg cttgtgcggg cttcatgtac ggggttgtaa ccggtaaaca atttattgaa 1127041 tccggaacct acaagcatgt tctagttgtt ggtgtagaga agctctcaag cattaccgac 1127101 tgggaagacc gcaatacagc cgttctgttt ggagacggag caggcgctgc ggtagtcggg 1127161 ccagtcagtg atgacagagg aatcctttca tttgaactag gagccgacgg cacaggcggt 1127221 cagcacttgt atctgaatga aaaacgacat acaatcatga atggacgaga agttttcaaa 1127281 tttgcagtcc gccaaatggg agaatcatgc gtaaatgtca ttgaaaaagc cggactttca 1127341 aaagaggatg tcgacttttt gattccgcat caggcgaaca tccgtatcat ggaagctgct 1127401 cgcgagcgtt tagagcttcc tgtcgaaaag atgtctaaaa ctgttcataa atatggaaat 1127461 acttctgccg catccattcc gatctctctt gtagaagaat tggaagccgg taaaatcaaa 1127521 gacggcgatg tggtcgttat ggtagggttc ggcggaggac taacatgggg cgccattgca 1127581 atccgctggg gccgataaaa aaaggtgagg tgcacacaag atgactaaaa aaagagtagt 1127641 tgttacagga cttggagcat tatctccact tggcaacgac gtcgatacaa gttggaataa 1127701 cgcaatcaac ggtgtgtccg gaatcggtcc gatcactcgt gttgacgctg aagaatatcc 1127761 ggcaaaagtt gccgctgaat taaaagattt taatgttgaa gattatatgg ataaaaaaga 1127821 agccagaaaa atggaccgct ttacacaata tgcggttgtg gctgcgaaaa tggcggttga 1127881 agatgcagat cttaacatta ccgatgagat cgcgccgaga gtcggtgttt gggtaggctc 1127941 cggtatcgga ggacttgaaa cactagagtc tcaatttgaa atcttcttaa caaaaggccc 1128001 aagacgggta agcccgtttt tcgtgccaat gatgattcct gacatggcga caggccagat 1128061 ttctattgca ttaggagcaa aaggggtgaa ctcttgtacg gttacagcat gtgctacagg 1128121 aacgaactcc atcggtgacg cgtttaaggt tattcagcgc ggtgatgcag acgtgatggt 1128181 cacaggcgga acagaagcgc cgctgacaag aatgtcattc gccggcttta gtgccaacaa 1128241 agcgctgtct actaatccag atccgaaaac agcgagccgc ccgtttgata aaaaccgtga 1128301 tggctttgtc atgggggaag gtgcagggat tatcgttctt gaagaacttg agcatgccct 1128361 ggcccgcggc gctaaaattt acggagaaat tgtcggctac ggctcaaccg gagacgctta 1128421 tcatatcaca gcgccggccc aagacggtga aggcggagcg agagcgatgc aagaagccat 1128481 taaagatgca ggcattgcac ctgaagaaat tgattacatc aatgctcacg ggacaagcac 1128541 gtattacaac gacaaatacg aaacaatggc gattaagacc gtttttggcg agcatgcgca 1128601 taaacttgcg gtaagctcta caaaatcgat gacaggccac ctcttaggag cagccggcgg 1128661 tattgaagcc attttctcta tcctggccat taaagaaggc gtgattccgc cgacaatcaa 1128721 tattcaaaca cctgacgaag aatgtgattt ggattatgtg cctgatgaag cccgcagaca 1128781 ggaacttaat tatgttctca gcaactcatt aggattcggc ggacacaacg caacattaat 1128841 ctttaaaaaa tatcaatcat aatcaagcca aaccggctgc ccttaaaggg tagccggttt 1128901 tttttgtgtg cataggatta aaagaggagg cgatcacatg agtgtagaac aaacatatag 1128961 ctggctcagg aaggccggtt caatagatga tttggcgcat tacattatcc cgcttttttc 1129021 aggtgcggag aaaaagaact ggaagggcat tctggggcat cttcagcatc atgggatgtt 1129081 taaaaacata aaagagggta ttcagacggt ttccaagctg aaggaaaaag gtttttacgg 1129141 acatatccaa aaggaagaac agtacctcaa aaacaaatgg caaggtcctg atgtaccaat 1129201 tgttacgctg ccggttgatg aacgaaacag gagaatccgt ttagaattcg gatcaaaatc 1129261 aggactcgcc tttcaagaca aaatgttcct ttttctttcg tcagatttag attttgggtc 1129321 ggtatctgcc cttatgacgc atgagtatca tcacgtttgc cggttaggtc atctgacaaa 1129381 agaggaaaag gatgtcacat tacttgatac aatcatcatg gaagggctgg cggaatatgc 1129441 tgtttatgag aggttcggcc gaagtcaaac ggctgaatgg acgacttggt atacaccgga 1129501 acagcttcag gctttatatg aaaaaaagat tgcgccccat cgggatatca aacgggataa 1129561 tcgattattt ccccagctgt tattcggcaa aggatatcag ccaaaaatgc ttggatacgc 1129621 agttggattc aatattgtaa aaaaatattt aaccgccagc aaggcaagca ccgcagacgg 1129681 gctgtccatt cctgctgaga cctttttgga tgcaatgctt taaaaggata aaataatgga 1129741 atttcattaa taatattaca tttatcctaa aaaattcttg attttgcaaa atgattgtaa 1129801 taatatacaa ctataaaatt tttcgataat tcaatattat ttattatttc tgaataaagg 1129861 gattgctttc tcttgaaaac gtttgacaac aagagggggg aaaggggagc tagcatgagc 1129921 acacttttag aagtgaataa tttaaagact tattttttca ggaaaaagga gccgatccct 1129981 gcggttgacg gagtcgattt tcacatcagc aaaggcgaaa ccgtcgcgct tgtaggtgaa 1130041 tcgggctccg gaaaaagcat tacttcttta tcaattatgg gcctcgtcca aagctcaggc 1130101 ggaaaaatca tggacggctc tattaaactc gaagacaaag acctcacctc attcactgaa 1130161 aacgattatt gcaaaatccg cggtaacgaa gtatccatga tctttcagga accaatgacc 1130221 tcccttaatc cggtgttaac aatcggagaa caaattaccg aagtgctgat ttaccataaa 1130281 aacatgaaga aaaaagaagc ccgtcaacga gctgttgaac tcttgcagat ggtcggtttc 1130341 tcccgggcgg agcaaattat gaaggagtac ccgcatcggc tgtccggcgg tatgagacag 1130401 agggtgatga ttgccatcgc actgagctgt aatcctaaac tgctcattgc tgatgaacca 1130461 acgacagcgc tggacgtgac aatacaagcc caggtgctgg agctcatgaa agatctctgt 1130521 cagaagttca atacatcgat tcttctcatc acacacgact taggtgtcgt gtctgaagct 1130581 gccgatagag tgattgtcat gtactgcgga caagtcgtag aaaacgccac tgttgatgac 1130641 ttatttttag aaccgcttca tccgtataca gaaggcctgc ttacgtcaat tcctgttata 1130701 gatggagaga ttgataaatt aaatgcgatt aaaggcagtg tgcctacacc ggataatctg 1130761 ccgccggggt gccgttttgc cccaaggtgc ccgaaagcta tggataagtg ctggacaaat 1130821 cagccttcgc ttttgacaca caaaagcgga agaacggtga gatgcttttt atatgaggaa 1130881 gagggtgccg aacaatcatg acagcagcta atcaagaaac aatcttagag cttcgtgacg 1130941 taaaaaaata ctttccgatc cggtcaggcc tttttcaaag aaaagtcggt gatgtaaaag 1131001 cggtggatgg tgtttcattt tcgttaaaaa aaggagaaac actcggaatc gttggagagt 1131061 cgggctgcgg aaaatcgact gccggcagaa cgatgatcag actgtacaaa ccgacagagg 1131121 gccaaattct ttttaaaggg caggatattt ccaatctgtc agaggagaag ctgcggaaga 1131181 gtgtccgcaa aaatattcaa atggttttcc aagatccatt tgcttcgtta aacccgagaa 1131241 agaccctgcg ttccatcata aaggagccgt ttaatacgca caacatgtat accatgcgtg 1131301 aacgaaacga aaaagttgaa gagctgcttg caagagtagg gcttcacccg tcgtttgccg 1131361 gccgttatcc ccatgagttt tcaggcggcc agcgtcagcg gatcggcatt gccagagcac 1131421 tcactttgaa tccagagctg atcattgcag atgagccggt ttccgcactt gatgtatcca 1131481 ttcaggccca agtgattaac ttgatggagg aattacagga agaatttaat cttacgtatc 1131541 tatttatctc tcatgatctg agtgtcgtcc gccatatcag cgacagagtc ggagtaatgt 1131601 atcttggcaa aatgatggaa ctgaccggca agcatgagct ttatgacaac ccgcttcacc 1131661 catataccca agcgctttta tcctccgttc cggttacaag aaaaagaggt tctgtcaaac 1131721 gtgaacgcat tgtcctgaag ggagaactgc ctagtccggc caacccgcca aaaggctgcg 1131781 tattccacac aagatgtcct gttgcaaaac cgatatgcaa ggaacaaata ccagaattta 1131841 aagaagctgc tcccagccac tttgtggctt gtcaccttta tagctaatgt tgcccgcaca 1131901 gctttgagag ggggtatgca cactacataa acaacagcct agaagaacga acatttcaag 1131961 agggggaata tctaatgaaa agacggaaaa ccgcactgat gatgctaagt gtattgatgg 1132021 ttctggccat ctttttatca gcctgctcgg gatcaaaatc aagcaacagc agcgcgaaaa 1132081 aatcagcagg caaaccgcag caaggcgggg atttggttgt tggttcaatc ggagaaccca 1132141 cactttttaa ctctctgtat tctaccgatg acgcaagtac ggatattgaa aatatgctgt 1132201 acagcttttt aacgaaaacg gatgaaaaac taaatgtgaa attgtcactc gctgaaagca 1132261 ttaaagaatt agacggcggc cttgcatatg atgtgaaaat taaaaaaggc gttaagtttc 1132321 atgacggaaa agaactgact gcagacgacg tcgtatttac gtacagtgtc cctttaagca 1132381 aagattacaa gggagaacgc ggttcaacat atgaaatgct gaaatccgta gaaaaaaagg 1132441 cgattacgaa gtcttgttta agctgaaata taaagacggt aatttctaca acaatgcgtt 1132501 agacagcaca gctattctgc cgaaacatat tctcggtaat gttccgattg ctgatttaga 1132561 agaaaatgag tttaacagaa agaaaccaat cggttcagga ccatttaagt ttaaggaatg 1132621 gaagcagggc caatatatta agctcgaagc gaatgatgat tactttgaag gaagaccgta 1132681 tttagatact gtgacgtata aagtcattcc tgacgcaaat gctgccgttg ctcagctgca 1132741 ggcaggcgat attaatttct ttaatgtgcc cgccactgac tacaaaacgg ctgaaaaatt 1132801 caacaaccta aaaatcgtta ctgatttggc attaagttat gtgtacatcg ggtggaatga 1132861 aaaaaatgaa ttattcaagg ataaaaaggt tcgtcaagcg ctaacaaccg ctcttgaccg 1132921 cgagtcaatc gtcagccaag tattagatgg agacggcgag gtagcttaca ttccggaaag 1132981 ccctttatct tggaactatc ctaaagatat agatgttccg aaatttgagt acaacgagaa 1133041 aaaagcgaaa cagatgcttg cagaagccgg ctggaaagat acgaacggtg acggcattct 1133101 ggataaagac ggaaagaaat tctcgtttac ccttaaaacg aaccaaggaa acaaagtccg 1133161 tgaagacatc gctgtcgtcg ttcaggaaca gctgaaaaaa atcggcattg aagtgaaaac 1133221 ccagatcgtt gaatggagcg ctctcgttga acaaatgaat cctccgaatt gggattttga 1133281 tgcaatggtc atgggatgga gtttatccac attcccggat caatatgata ttttccattc 1133341 aagccagatt aaaaagggtt tgaactacgt ttggtataaa aatgccgaag cggataaact 1133401 catgaaagat gcaaaatcaa tcagtgacag aaagcagtat tcaaaagaat atgagcaaat 1133461 ctatcaaaaa attgcggaag atcagccgta tacgttcttg tattatccta acaaccatat 1133521 ggcaatgccg gaaaatcttg aaggatacaa atatcatccg aaacgtgatt tgtataatat 1133581 tgaaaaatgg tggcttgcaa aataaatttc ccttaaaggg gagggagagc gttttctccc 1133641 tcttctgttt ttaataagga aagtaaaggg ggacaagtat atggctgcat atattatcag 1133701 aagaacctta atgtctatcc cgattttatt gggaattacg attttatcat ttgttatcat 1133761 gaaagccgcg cccggagatc cgatgacatt aatgatggac ccgaaaatca gccaggctga 1133821 cagagagcag tttattgaaa aatacggtct gaatgatcct cagtacgttc aatatttaaa 1133881 gtggctaggc aacatggtgc agggtgattt cggaacgtct attgtcagaa aaggaacgcc 1133941 tgtttcagaa ttgattatgg caagactacc caatacgctc ctgctgatgc tggtttcaac 1134001 gattttggct cttatgattt ctattccgtt cggtgtcctg tcggcaaagc ggccgtattc 1134061 aaaaatcgac tatggcatta catttacctc gtttataggc ctggctattc caaacttttg 1134121 gtttggatta attttgatta tggtgttatc ggtaaatctc ggctggtttc caactggggg 1134181 tgtcgagaca ctgaataccg aattcaatat atttgaccgg attcatcatt taattctgcc 1134241 tgcattcgtt ctagctacag ctgacatggc cggactgacg agatacacga gatccaatat 1134301 gcttgatgta ttaaatcaag attatattcg cacagcgaga gcaaaaggat ttaaagagaa 1134361 cagagtgcta tttaaacatg gattgaggaa tgcattatta cccgtcatta caattttcgg 1134421 tttgatgatt ccttcattta tcggcggatc tgtcgttgtc gaacaaattt tcacttggcc 1134481 gggattagga aagctgtttg tcgattcagc attccagcgc gattatccgg ttatcatggc 1134541 aatgactgtg atctcggcgg ttcttgtcgt tgtcggaaac ctcattgcag acatccttta 1134601 cgcgattgtt gatccgcgga tcgaatatta aaaggaggga aacagagatg tcagagctgc 1134661 aaacaactcc ctcgccggag atcaggctga aagaaaatat ttcgaaaaag ccagaaacaa 1134721 tgacaaagat tttctgggaa aaattctcga aaaacaaact ggccatttta ggtgccgtta 1134781 ttctttttat cattattatg tctgctgttt tcgccccttt aattgcacct tatccccaag 1134841 agcagcaaag cctgcttgat aaatataagg cgccgggcct tgaacatctg atgggaacgg 1134901 ataaatttgg acgtgatatt ttcagccgga tcctatatgg agcgcgtgtc tctttattgg 1134961 ttggatttgc gtccgtagtc ggttcgattt tgatcggaac ggttttagga gcattagccg 1135021 gatatttcag aggaatagtg gatgctgtca ttatgcgtgt agttgacatt gtgttatcca 1135081 ttcctgatat tttcttgttg atcacgctgg tcaccatctt caagccgggt gtggacaaat 1135141 tgattttaat tttctgtctc acaggatgga ccacaacagc acgattagta aggggagaat 1135201 tcttgtcgct ccgttcaagg gaatatgttc ttgctgctaa aacaattgga acaaaaacgc 1135261 acaaaattat tttttctcat atcctgccca atgcgttagg gccgattatc gtgtcagcta 1135321 cgctgaaagt tgggtctgtt attctagctg aatcggcgct aagctacttg ggctttggaa 1135381 tccagccgcc aatcgctagc tgggggaaca tgcttcaaga cgcacagaat ttcacagtaa 1135441 tgattcaagc atggtggtac ccgttatttc ccgggctatt tattttaatg accgttttat 1135501 gcttcaactt tgtcggtgat ggcctgcggg atgcgcttga cccgaaaaat attaaataaa 1135561 aatgaatatc atatctgtta taaaatatca ccaaatcaga aaaaagcagg tctcctttag 1135621 tcagaaaata tacaaagaga tctgcttttt atgattctta cataaaccca gtgattccag 1135681 atttcctcaa tctctttgga ataatttctc tatcccttgc ctatactgtg gacaacagtt 1135741 tttataaaag tgaggggtta gagatgttat ttcttcatga tgtgtgggtc aattggtttg 1135801 aaggggaaga aaatggctac aatgtatgcc actttcacga atggcgcaag gaagatacgg 1135861 ttgagctttt ggatcaggtg ccgctgttaa gggtgccgtc agtactgttt cattacatag 1135921 aaaacgattt gtcagagctt ccgaaaggtt tgcttgaaga cgtacatcag aaatcgtaca 1135981 ttcgaaaaaa tcatgagcgg acaaagcttg agtattgttt tgtcgtaaca gacggaatcg 1136041 gcattttagc tgttgacacg atcggctaca cgatccctgt cagaaaaagc cgtctaatcc 1136101 caagacagga gcagctcgtt tatgaaatgg taaaagatgt agagcctgaa acatatgaat 1136161 ttgagccaaa gaagctggaa tcctccaagg aatatcacat cttatcatta gcaccagaac 1136221 atgtcagagg actgacaaga aaagaacggc aaattaagca gctgatgttt atggcgcttg 1136281 accaattaaa agggctgaaa aaccgagcgg aaattggcta ctggtacaca gagtggaatc 1136341 cgcatatgta tgaacaaatc aaaaggatga gctttgaaga gatttgggac atgctgtata 1136401 acgaaacaat tgaaggctgg tcggacaaac acctagcttt ttgcgaaaac ctaataaaag 1136461 gacagccttt tttcgaaaag ctttgggaaa tggaaaacga atcaaaggtc aactgaaaaa 1136521 aaccgctctt tgcaaagagc ggttttttga ttagcgtctt tttcttccaa gacccatggc 1136581 attctccatt tttttcagca ttttgtttgc tgtccgattc gctcgttccg cgccttcatc 1136641 aagaatccgg tctaattctt cagattctat cagctcgtaa tagcggtcct ggatcggttt 1136701 taatgcgttc actacgactt ctgccaaatc acctttaaac tcgccgtagc cttttccttc 1136761 gtactttgct tcaagctctt caattgtcgt attgccgagg attgaataaa ttgtaagaag 1136821 gttggaaacg cccggtttgt tttccttatc aaatttgaca atgccttcag aatccgttac 1136881 tgcgcttttg attttctttt caagctgctt cggctcatcc agcaatgtaa tataagcttt 1136941 ctgattcgga tcagatttgc tcattttctt cagcggatca ttcagagaca tgatacgtgc 1137001 accgactttt ggaattttca cttccggaat cgtaaagatg tcgttgtatt ttttgttgaa 1137061 gcgttctgca agattccgcg tcagctcaag gtgctgcttt tgatcctcgc cgacaggtac 1137121 aagatccgtt ccgtacagca gaatatcagc ggccatcagc ggcggatatg ttaacaggcc 1137181 ggagacgaca gcttcattgc ctttggattt gtccttaaat tgagtcatcc gctcaagctc 1137241 gccgatatag gcgacacact gcatcatcca tccggcctgc gcatgtgcgg ggacctctga 1137301 ctgaataaac aatgttgctt tttctggatc aagtccgaca gctaagtaaa gcgccgcgag 1137361 attgcggata ttctttctaa gctcaagccg gtcttgagga acagttatcg catgctgatc 1137421 gacgatgcaa aaatagctgt tataatcatg ctgcagttcg acaaactgct tcattgcacc 1137481 gatatagttg ccgagcgtca ctgagccgct tggctgaatg cctgaaaaaa tcgtttgttt 1137541 catgaaaaca tcaacctcat ttcttaaaac ataataaaaa aggctcattc ttcccctgta 1137601 aaaaagggac gaatgaaccg tggtaccacc ctgattattc cattaaaatg gaatcactct 1137661 gacgtttgta acggagactg ctccggctga gcctactttt ttccagttcg gtcagctgct 1137721 ccaaagtcca ttccacattg cccgttatct gctcccagca ccgcagactc tcttcaaaca 1137781 ggtgaaacgt gtactactct ttttcatagc aagcttttct tttgattgct tcattataaa 1137841 tcaattataa ccaattgtca tcatgaaaaa acattctttt ttccagtaaa attgtaataa 1137901 tataaataac acgagtgctg taaaatcctt aaatgataac tgctatcagc gtaaaaacag 1137961 gcagatatta tatgtaaaaa gcaatatggg cagaaaacac atgaaaaagt ttttaatcaa 1138021 tttatgcttt aaatggtaga aggatattat gttcatggaa gaaaaactaa cgaagtttaa 1138081 atattttaaa ttgataaaat aatattgcaa taaattattt gtttcattat aatgaacttg 1138141 ttcactctat tgttacagct tttttacaaa aataatcaga aaagacggaa cagaataaaa 1138201 gttgtggaaa ctcaggttca tttgtctgat atttctgagg atttagccgt aaggagctga 1138261 aaattattat tagggggttt gcgaatatga aaaaacgttg gtcgattgtc acgttgatgc 1138321 tcattttcac tctcgtgctg agcgcgtgcg gctttggcgg cagcggatca aacggtgaag 1138381 ggaaaaagga cagtaaagga aagacgacac ttaacattaa tattaaaact gagccgttct 1138441 ccttacatcc gggattggca aatgattcag tatcaggcgg tgttatccgt cagacttttg 1138501 aaggattgac acgtatcaat gcagatggtg agcctgaaga aggcatggct tctaaaattg 1138561 aaacgagcaa ggacggaaag acatatacat ttaccattcg tgatggtgtg aaatggtcta 1138621 atggagaccc tgtaactgca caagattttg aatatgcttg gaaatgggcg cttgacccta 1138681 ataatgaatc acaatacgct taccagctct actacataaa aggtgctgaa gcggcgaata 1138741 ccggaaaagg cagcctagac gatgtggcag taaaagctgt gaatgacaaa acgctgaagg 1138801 ttgaattaaa taacccgact ccatatttca ctgaattaac tgcgttctat acgtatatgc 1138861 cgatcaataa gaaaattgca gagaaaaata aaaagtggaa tacaaatgcc ggagatgatt 1138921 atgtatcaaa cgggccgttc aaaatgacgg catggaaaca cagcggctct attactctcg 1138981 aaaaaaatga ccagtattgg gataaagaca aagtcaaact gaagaaaatc gatatggtta 1139041 tgatcaacaa taacaatacg gaactaaaaa aattccaagc tggcgaactt gattgggccg 1139101 gtatgccgct cggacagctt ccgacagaat ccctgccgac cctgaaaaaa gacggttctt 1139161 tacatgttga gccgattgca ggagtgtatt ggtacaaatt caacactgaa gctaagccat 1139221 tagacaacgt caatatccgt aaagctttaa catattcgct tgaccgtcag tcgattgtta 1139281 aaaacgttac gcaaggagag caaatcccgg caatggctgc agtgccgcct acaatgaagg 1139341 gatttgagga taacaaagaa ggatacttca aagacaatga tgtcaaaaca gcaaaagaat 1139401 accttgaaaa aggcctaaaa gaaatgggct taagcaaggc atctgatttg ccaaaaatca 1139461 aattgtctta caacactgat gacgcacacg cgaaaatcgc tcaagcagta caagaaatgt 1139521 ggaagaaaaa tttaggcgtt gatgttgagc ttgataactc agagtggaat gtctatattg 1139581 ataagctcca cagccaagat tatcaaatcg gccgtatggg ctggctcggc gacttcaatg 1139641 atcctatcaa cttccttgaa ttgttccgcg acaaaaacgg aggaaataac gatacaggct 1139701 gggaaaatcc agaattcaaa aagcttctga atcagtcaca aactgaaaca gataaaacaa 1139761 aacgtgcaga gctgctgaaa aaagcagaag gtattttcat tgatgaaatg ccggttgccc 1139821 caatctattt ctatactgat acttgggtac aggatgaaaa cctaaaaggt gttatcatgc 1139881 caggtactgg tgaggtttat ttcagaaacg catattttaa ataaggctac gtctgaaaat 1139941 aaaagacctc aaggtatatg gggagaaaag ccccatatac ctttcttact gatggagtat 1140001 aaaaatgtaa aaaccatgga ggtgttcccc cttgctaaaa tatatcggaa gacgcttagt 1140061 ctatatgatt atcacactat ttgtgattgt aactgtgaca ttcttcttaa tgcaagcagc 1140121 accgggcggg ccattttcag gtgagaaaaa gcttccgcct gaaattgaag caaatttaaa 1140181 tgcgcattat ggcttggaca agccgctgtt tgtacaatat gtcagttatt tgaaatcagt 1140241 tgcaatgtgg gatttcggac cgtcatttaa atataaaggt cagagtgtta acgacctgat 1140301 cagttcaggt ttccccgttt catttactct tggagcagaa gctattctcc tcgctttagc 1140361 gttaggtgta ttgtttgggg tcattgcagc cctttaccat aataagtggc aggattatac 1140421 cgtcgcgatt ttaacgatat ttggtatttc ggttccgagc tttatcatgg cggctgttct 1140481 gcaatatgtg ttctccatga agcttgggct gtttccggtc gcggggtggg attcctgggc 1140541 atacaccttt ttgccttcca tcgcacttgc ttccatgccg atggcgttta ttgccagact 1140601 ttcccgttca agcatgatcg aagtgttaaa cagtgattat atccgcacag cgaaagcgaa 1140661 agggctttcc cgcccagcgg ttacagtgcg gcacgccatt cgaaacgcac ttttgccggt 1140721 tgttacatat atgggcccga tggccgcaca ggtcttaacg gggagcttca ttattgaaac 1140781 catttttggg attccggggc ttggtgcaca cttcgtcaac agtattacaa accgtgatta 1140841 tacggtcatt atgggtgtaa cggtgttctt cagtgtcatc ttgctattgt gtgtattaat 1140901 cgtagatgtg ttatacggca ttattgatcc aagaatcaag ctttccaaag caaagaaagg 1140961 agcctaggcc atgcagaaca ttccaaaaaa catgtttgaa ccagccgcag cgaatgccgg 1141021 cgatgcagaa aaaataagta aaaagagcct ttccctctgg aaagatgcga tgcttcgctt 1141081 ccgcagcaat aagcttgcaa tggtcgggct tatcattatc gtacttatta tccttatggc 1141141 aatttttgcg ccgatgttct caaggtatga ttattcaact actaatctct taaatgcgga 1141201 taagccgcct tcaaaagatc actggttcgg aacagatgat cttggacggg acattttcgt 1141261 ccgtacatgg gtaggggcgc gaatctcaat ctttatcggt gttgcagctg ctgttctcga 1141321 tttgctgatc ggcgtcattt gggggagcat ttcaggcttc cgcggaggaa gaacagatga 1141381 aatcatgatg cgtatcgctg atatcctttg ggcagttcct tcattattaa tggttatctt 1141441 actgatggtt gttcttccga aaggtctatt tacgattatt attgccatga cgattacagg 1141501 ctggattaat atggccagaa tcgtgcgcgg acaagtgctg cagctgaaga atcaggagta 1141561 tgtgcttgct tcacagacac tgggtgcaaa aacatcccgt cttctattta aacatatcgt 1141621 gccaaacgca atgggttcta ttttggtcac gatgacactg acagttccta ctgcgatttt 1141681 tacagaagcc tttttaagct atttgggact tggtgttccg gctccgctgg caagctgggg 1141741 aacgatggct tctgacggat tgcctgcatt gacctattat ccgtggcgtt tattcttccc 1141801 tgccggattt atctgcatta caatgtttgg ttttaacgtt gtcggcgacg gattaagaga 1141861 cgcattggat cctaagttac gtaaataagg gagtgatacg ggtgacacgc ctattagaag 1141921 taaaagattt agcaatttca tttaaaacat atggcggaga ggtccaggcg atccgcggag 1141981 tgaatttcca tctggataaa ggggagacgc tggccattgt tggagaatca ggttccggaa 1142041 aaagtgtaac ctctcaagcg attatgaagc tgattccaat gcctccgggt tatttcaaac 1142101 gcggtgagat cctgtttgaa ggaaaggatc tggtgccgct gtccgaaaaa gaaatgcaaa 1142161 atgtccgggg aaaagagatc ggcatgatat tccaagatcc gatgacctct ttaaatccaa 1142221 cgatgaaggt cggtaaacaa attacggaag tgctttttaa acacgaaaag atctcgaagg 1142281 aagcggctaa aaaacgcgcg gttgaactgc tggaattagt cggtatccca atgccggaaa 1142341 agcgggtgaa ccaatttccg catgaatttt caggcgggat gagacagagg gttgtcattg 1142401 ccatggcgct tgcagcgaat ccgaaacttc tgatcgccga tgagccgaca actgctcttg 1142461 atgtaacgat tcaagcgcaa attttggaat taatgaagga tttgcaaaag aaaattgaca 1142521 cgtccatcat ctttatcaca cacgatcttg gtgttgtggc taacgttgct gaccgggtcg 1142581 ctgtcatgta cgcgggacag attgtagaaa ctggtacggt agacgaaatc ttctacgacc 1142641 cgagacatcc gtacacttgg gggcttcttg catccatgcc gacactggaa agttcaggag 1142701 aggaagagct gactgcaatt ccgggcacgc cgcctgattt gacaaacccg ccaaaaggag 1142761 atgcttttgc cctgcggagc tcttacgcga tgaaaatcga ttttgaacag gagccgccaa 1142821 tgtttaaggt atccgatact cattatgtaa aatcgtggct gcttcatcct gacgcgccaa 1142881 aggtagagcc gcctgaagcg gtaaaagcga aaatgcgtaa actggcaaac acgtttgaaa 1142941 aacctgtctt agtgagagaa gttgaatgaa ttgactgaaa aactattaga aatcaaacat 1143001 ttaaaacagc actttgtcac gccgagggga acggttaagg ctgtagatga tttatcattt 1143061 gatatctata aaggtgaaac attagggctg gttggtgaat ctggctgcgg taaatcgaca 1143121 acaggccgaa gcattatcag gctgtacgaa gcaaccgatg gtgaggtgct gttcaacggc 1143181 gaaaatgtgc acgggagaaa atcgcggaaa aagctgctgg aattcaaccg caaaatgcag 1143241 atgattttcc aagaccccta tgcatccctg aatccgagaa tgacagttgc tgatattatt 1143301 gctgaaggcc ttgatattca taagctggca aaaacgaaaa aagagcggat gcagcgagtt 1143361 catgaactat tggaaacagt gggattgaac aaggaacacg cgaaccgcta tcctcatgaa 1143421 ttttccggcg gccagcgcca aagaatcggg attgccagag cgcttgctgt tgatccggaa 1143481 ttcattatcg cggatgagcc gatttccgct ttggatgtat ccattcaagc gcaggtcgtg 1143541 aatttaatga aagaactgca aaaagaaaaa gggctcacat acctgtttat tgcccacgat 1143601 ttatcgatgg tcaaatacat cagtgaccgc attggcgtca tgtatttcgg gaaactggtt 1143661 gagcttgcgc cggcagatga gctttatgaa aatccgcttc acccatatac aaaatcattg 1143721 ctttctgcga ttccgcttcc tgatccggac tatgagagaa atcgcgttcg ccagaaatat 1143781 gatccgtctg tccatcaatt aaaggatggg gaaacgatgg aattccgtga agtcaaaccg 1143841 ggacattttg tgatgtgcac ggaagccgaa tttaaagctt tttcatgatt catcaatcct 1143901 tcaagagatt tctcttgaag gatttttttg cgtcttcata gaaagtgaga atgataacat 1143961 ttacaattag aggaaaaagc ggaggcgaaa tacgattcaa tttctgcata acaaaaatgt 1144021 ttttgcgcta ttgctgtctc aatcttttca atctttagca ggagtcctcg tcacaatcgt 1144081 tttaatggtc cggatctatc aaatgactga ctccgttttt ttggcgggcc ttattttatc 1144141 gttcatgtcg tttgcgagta tagcagcaag cttttgcgtc tctccggtgc ttcgcattct 1144201 cggttttaaa aaggtgcttg cgggagcgaa tctgctgaga gcggtcttta ttatactgat 1144261 ggcatacagc gtcactcatc acggacaggc attcttttgg attacgctgc tgtttgtgtt 1144321 ttgtttttcc ttcgcgggcg ctttttttca gccggcaaga tttgcgctgc tgccgattat 1144381 tgttccaaag aagcaatatg taaaagcgaa tggtgtgatc tccctctcga atcaattgtt 1144441 cttaacagca ggctggggcc ttggaggcct tctgacgtac gccgtccctt ttgaactcgt 1144501 tgtcggcgct gccatttgcc tgtttgttct atcgggagct tccatcagtg tgctgcatgt 1144561 aaatgaagaa gaggctgcag gaactgctga aacagcatct gtcagaagta tatggaagga 1144621 tttaatgatc atccctattg taagagacat tactgtaatg gacatgttag aagctttggc 1144681 gggttccgta tggtcatctg ctattctcct cgcatttact gcggctgttt tgcatgaaac 1144741 agaggtgtgg tgggggatgt ttaacgcttc ctattttata ggcgcaattg tcggcagtgt 1144801 gattgctatt cgtttttctt ctttttttga gcggaatatg ggctatgcca ttatgttcag 1144861 ctcgcttgta atgtcggcgc tgaccctttt gttttcattt tctccagtcc catttttatg 1144921 cgctctggct tgtgctgcaa tggggccttt ttatcaggtg cgtgatattt gccaggaaac 1144981 catgctgcag gaagttattc ccgagcagaa acgaatcgga atcatggctg caaaaaatgc 1145041 gattttgact ccttggtcag gcgtcaccta ctccattatg gggctagtgg ctgatgctgc 1145101 tggtgcgaaa atagctttta tcgcggctgc tgcattatat atcatgacat ttctgattgc 1145161 actggcgcag ccccgtctgg ttcattacag gcgagaaaat cgagttcaat gagaaacact 1145221 tcaaaatgaa cggagcagct ggctccgttt tgctgaaaaa aaaatgaaac catggcggaa 1145281 gttcgcacgt ctttatagat gtaaggctgt ttaaacaaga agaaatgggg tatatctaaa 1145341 agtatgaaga caacgaactc ataaggagca aatcaatgaa ctggtatgaa aagcttagcg 1145401 agtactttcc aattgaagaa atgaaatcaa aagcgcatat ggaagctctt ctgaaagagc 1145461 gaagcgatat ttatcataaa gatgaaggca aacatcatat tttaatgttt gcggaattcg 1145521 attcttttat cttcgttgat tatctgtatg tgtctaagga tgcaagaggg caggggcttg 1145581 gcggcaaatt gatcgcgaag ctgaaaaaga aaaataagcc catattgctc gaggtggaac 1145641 ctgtggatga agatgatact gatacagaaa aacgcctgag gttttatcaa agagagcatt 1145701 tcaagcatgc tcagtcaatt gggtaccggc gccggtcatt ggctacgaat gaagtaaaca 1145761 agatggagat tctgtactgg tcaccaaaaa cagaatcaga agaagaaatt cttgaagcca 1145821 tgaaacagac atatgaaaac attcatactt ataaagatga gaaatggtac ggagaatcgt 1145881 acgaaaaaac ggatgaggtc ttggaaatca tcgatgaaga aaaacaaaaa aatattttcg 1145941 atcagttaag ctaattgaga ataagaacat atcatgaaca ttaaaaattt gctggattga 1146001 cacatttttt tcttaggata ctgttcacac ttactttttt atagtataat acctgtaaag 1146061 attccttttt tagagtaatt tcaatttaag aataaaatag atgttcatcc tactaattag 1146121 aggagtgaag atgaatggtt acactataca catcaccaag ctgtacttca tgcagaaagg 1146181 cgagagcgtg gctcgaggag cacgagattc catttgtaga aagaaacatt ttctctgaac 1146241 ctttatcaat tgatgaaata aaacaaattc ttcgaatgac tgaggacgga acagatgaaa 1146301 tcatctcaac ccgttcaaaa gtattccaaa aactgaatgt gaacgttgaa tctatgccgc 1146361 tgcaagattt gtaccgcttg atcaacgagc atccaggttt gcttcgccgt ccgatcatca 1146421 ttgacgaaaa acgtttgcag gtcggatata acgaagacga aatcagacgt ttcctgccaa 1146481 gaaaagttcg ctctttccaa ttaagagaag cacagcgttt ggcaaactaa tagatcgtat 1146541 catcaaaaga aggctgagtc atcagccttc ttttattttt caacctgctg gtaataaatg 1146601 ctcgcaagga tgacaaacgc aaccgtcaaa atggggagga gcgtttcgac tgtgccgtgc 1146661 tgcgccataa aaagcgacag ctttttgtct ctgacaatca tttctccgcc agtataagca 1146721 agcagcccgc ttcccgcgta aatcagaagc ggtattttct ctagtgcaat atggatgagt 1146781 ttgctgcccc aaataataac cggaaccgat acacacaatc ctataacaac gagagaaaac 1146841 tcaccgtgtg aagctcccgc aactgcgatg acgttgtcca gcgacataaa gagatctgca 1146901 agcacaatcg ttcgtatcgc tctccacagg gaggtgctgc ttttaatgtg tttcgtgtct 1146961 tttttttcaa tcagcagctg atatcctaaa tacagcagga aaattccgcc ggcgcactgc 1147021 aagaacggaa tgttcaaaag atatactgct gcacttgtta atccgattct catggcaacg 1147081 gcaataaatg ttccgagaat aatggcttgc tgtctttgct tgtccggcaa atgtctgctg 1147141 gccatggcaa taacaaccgc gttatctccg ccgaggatca ggtcaatccc aacaatgacg 1147201 agcagagaaa tcagatagtc atgctccatg aagcggcacc tcgctttcag tccttcgctt 1147261 gtactactac tatatgagac aggtcatatt ttatgatatc agccgcctga tctgccgttt 1147321 tttaggcaaa ggtgcatttt tatttctttt gtgactgttt tatcataaaa tagaaataca 1147381 aaggaattca cactggcctt ggttaaggtt aagatgtgga cggaatgggt aaagtgtagt 1147441 aaagtacaat taatcgggag cttagatgtc ccttcaacat cttatataga agggaaggtt 1147501 ggcaaatgga aattgaaaga attaacgagc atacagtaaa attttatatg tcttacggag 1147561 atattgaaga tcgcggtttt gacagagaag aaatttggta taaccgtgag cgcagtgaag 1147621 aacttttctg ggaagtcatg gatgaagttc atgaagaaga ggaattcgct gtggaaggcc 1147681 cactttggat tcaagttcag gcactggaca aaggattaga aatcatcgtc acaaaagccc 1147741 agctttccaa agacggacaa aagctcgaac tgccgattcc tgaggataaa aagcaagaac 1147801 cagcatctga ggatcttgac gccttgctgg atgatttcca gaaagaagag caagccgtca 1147861 atcaggaaga gaaggagcaa aagcttcaat ttgtcttgcg atttggcgat tttgaggatg 1147921 ttatttctct atctaaattg aacgttaacg gaagcaaaac gactttatat tcgtttgaga 1147981 accgatatta tttatatgta gatttttgca atatgactga tgaagaggtt gaaaatcagc 1148041 taagcatcct gctggagtac gcaactgaat cctcaatcag catacaccgt cttgaagagt 1148101 acggcaagct gattatttca gagcatgctc tagaaacgat aaaaaaacac tttgcatcat 1148161 agcaaaccga tttccttccg gaaatcggtt ttttttatgc acgaaaatgc cattttagag 1148221 atgtgaaaaa tcaaaaacat atagacaagc agaaaataca gcgaacagga gttgatcatc 1148281 ttttccagaa agtatacttc atctggaaag gagagatgac aattgtttag tgctgtgact 1148341 gaagacggcc aaatgtttca ccttctaggc gctcagcaaa accagaaatt aaagcggaga 1148401 cggttcttct gtccggtatg cgggggagag ctagctgtga agctcggact tcaaaaagcg 1148461 ccgcattttg cccataaaca gaacaagtcc tgcgccatag acatcgagcc ggaaagcgcc 1148521 taccacttag aaggaaaaag acagctgtat gtatggctga aaacgcaacg ggcttcacca 1148581 atattggagc cgtatataag gacaatcaac caaagaccgg acgtcatggc aagaatcaag 1148641 gagcatatgc ttgctgttga atatcaatgc gccactatcg ctccagatgt ctttcaaaag 1148701 cggacagagg gcttcaaaca agaaggaatc atcccgcagt ggattatggg atacagccgc 1148761 ttaaaacgga ctgcttcgtc cttttatcag ctttcaactt ttcattggca gtttatcaat 1148821 gcaagtccat acagagaact gatatgttat tgtcctgaaa ggcgttcttt tctccggctc 1148881 agccacatca ttccattcta cacaaaccat tcttattcct cagtccaaac gatccctatc 1148941 catcgggcag gtgcaggcga tctttttttc actgaaccga aaccctcaat tcaatattca 1149001 ggctggacga aagcgattca ccgttttcgc cataaacccc atcggtttaa ctcaaaggaa 1149061 acaaatcgcc ttaggctgct gttttatgag aaacgacaga cgcctttttc ttttctgccg 1149121 actgaagtgt ttgttcctgt tagaaaaggg gcagttttta agagtccggt ttttgtgtgg 1149181 caggggtttc tttatttgtt tatgacggat cttggaggta aacgtgcgcc aattcgtttt 1149241 tcagccgttt tgcagcagtg caaactgcac attcataata agaacattgc actcaggtcc 1149301 gaatgcagcg aagagtgtct ttcagaagcg gttaaacagt atattgattt tttgtgcaag 1149361 aagggatttt taagggagac tcagaaagaa gtatatgtgc tgaatcagcc tgcaggaggc 1149421 atacactcca tgcaggatct catagaaaga gaccgcagct gttttataga atgagtttgt 1149481 cttatttggc tcaccctaag acaaaggtgg tgggcaggct gtgaaaggca caaaaggaaa 1149541 ggtttttcgt gtttttactg cttttttggc attcgttctc ttcattactg catatgattt 1149601 gacaaaaggc agtgaaaaac cggaagatat tcacaacaca agtttattga gaaacagctg 1149661 ttttttcaat tggcttgaat caaagaagac gagggggatc accatggctg aggaaaaaaa 1149721 agcaaaccaa ctgcctgaca gaagtgaggt aaaggcagaa gacacatgga gacttgagga 1149781 tatttttcct agtgatgagg cctggaataa agaatttcaa gctgtaaaag aattaattcc 1149841 gaatttatct aagtataaag gaaagctggc agattcagct gatcatttat acgaggctct 1149901 tacgtatcaa gataaagtga tggagcggct aggtaggctg tacacatatg cgcatatgcg 1149961 ctctgaccag gatactggga actcctttta ccaggggctg aatgacaagg cgggaaacct 1150021 gtatacacag gccgcaagcg cgacagctta tttggttccg gagattttat ccatagaaga 1150081 agacaaactg cagcagttca ttcttgaaaa agaagaattg aagctgtact ctcatgcgat 1150141 tgaggagatt acaaaggaac gtccgcatgt gctgagcgag aaggaagagg cgctgcttgc 1150201 tgaagcctcc gaggtactgg ggtcatcttc aaatacattc agcgtgttaa ataacgcaga 1150261 tataacgttt ccatccatta aagacgaaga tgggaatgaa aaacagatca ctcacggcaa 1150321 ctttattaat ttcttggaaa gtgaaaaccg tgaagtccgc aaaaatgcgt ttgacgcagt 1150381 gtataaaacg tacggacaat ataaaaacac aatggccacg acgctaagcg gcactgtgaa 1150441 aaaggacaac ttctacgcga gagtgaaaaa gtacaagtcc gcgcgtgagg ctgcgctttc 1150501 taacaacagt attcctgagg aagtatacga taaccttgtt aagacgatta ataagcattt 1150561 gccgctcctg caccgctata ttgcgctaag aaagaaagtg cttgagcttg atgaagtgca 1150621 tatctatgac ctgtatacac cgcttgtgaa agatgctggg atgaaggtga catacgagga 1150681 agccaaagat tacatgctga aaggcctcgc acctttaggg gaagaatatg cctctatcct 1150741 aaaagaagga ctggaaaacc gctgggtgga cgtttacgaa aataaaggca aacgcaatgg 1150801 ggcttattca tcaggagctt acggcacgaa tccgtatatt ttgatgaact ggcataataa 1150861 cgtcaataat ctctttacgc tcgtgcacga gtttggacat tccgtacaca gctactatac 1150921 gagaaagcac cagccttatc catacggcaa ttacagcatc tttgtcgcgg aagttgcctc 1150981 tacgacaaat gaagcgctcc ttggcgaata tttgctgaac aatttagagg atgaaaaaca 1151041 gcgcttatat attctcaacc atatgcttga gggcttcagg ggaacggtct tcagacaaac 1151101 gatgttcgct gaatttgaac atctgattca tacaaaggcg caagaaggcg agccgcttac 1151161 acctgagctt ctgacaaatg tctattacga cctgaataaa aagtattttg gagacggcat 1151221 ggtgattgat aaggaaatcg gccttgaatg gtcgcgtatt ccgcacttct attacaatta 1151281 ctatgtgtat cagtatgcga caggttacag cgctgcccaa gcattaagca gccagatttt 1151341 gaaggaagga aagccggcgg ttgaccgtta tattgacttc ctgaaagcgg gaagctcaca 1151401 atacccgatt gatgtcctga aaaaagcggg tgttgatatg acgtctccag agccaatcga 1151461 agccgcgtgc aaaatgtttg aagaaaaact tgatgaaatg gaagagctgc tgatgaaagt 1151521 caagcagtct taaaaaagta agcctgtgcg gaaatgacgc acaggctttt ttaaaaccct 1151581 ttaaaggttt tccggtgatt caagcggtag agggtaaaca aaatagacag aaacagcaga 1151641 ggagaggtaa tataaagcgg cagcatatgc atcatgccta agatattcaa gcagaaaaaa 1151701 acagcaatgc acacaattga gatcaaagta gacatcatgg cggtcctcct cgtccttttt 1151761 ccttataagg atatgagtga atgcacttcg ttatgttttg tgacaaaaat atgaacatta 1151821 agcatagagg ttgtcaaaag tcgacatctt ttgttatcat aaggatgtga aattgatcac 1151881 aaacaaacat tacccctttg tttgaccgtg aaaaatttct cccatcccct ttgttgtcgt 1151941 taagacatat gaaaccgcgc ttatcccggc gcggtttctt tagtgctaaa aatggaacgt 1152001 acgtttggtt atggcataaa aaaacagcct caagcatatg cacgcctgcg gctatttttc 1152061 acatgattga tattcatcag aataagtgct gagagacttc caaaacattc cgtgtttggc 1152121 ttccactttg gcaacctttt tagcaaacgc cagttttttc atttcttttt ctacctcttc 1152181 aaggctcagg tcatatacaa gagcaatttc cttcgaggca acgaagcgga aatattcaat 1152241 aaaacattct aaaggcggtg tttccgacgg cttcggctcg tcgccaagca tctcaaataa 1152301 aatttcttca tatacatcat atgagtagct gccaggaact ttaagccctt catcctcatg 1152361 ctgcgtatta aaaaacgtca gtgtcggatt aacagaaaca tccatctcgg cagcaatttt 1152421 catgtcacat tgaagcgcct tgaccgcgct ttgagaatgc agatcttttt tgaattcttc 1152481 aagatcgaga cttgtatttt cagcaatctc caaaagcacg ttttcatccg taatattttt 1152541 ctttgaaaca aataggctct cctgcatatt tctgagaaat tgcatgccgg cttttcgtcc 1152601 ttgcagttcg gctgctttaa aagcgagagc agccatataa ggcgatgaaa gcggctgatc 1152661 ctgttcgaac cagacattgc cgtcacatga catgccagag cggctcgcga tcttttccca 1152721 tgcttctgcg agaagatgct tttttcgctt tttatttaaa gcggtaaggc ttgcggaagc 1152781 gataatgcgt aaggtgaaaa aacgtccgta tctgattttc agctttttga tgacgggctc 1152841 taaggaccag cattcaggac ataaagggtc tacaaacata taaatttcaa gcggtttttt 1152901 tggatgaccg tggcaatggg cgaagtatag ctcatgctga tagtttgtca agatgatcga 1152961 tcctccgctt ccgtttgatt caccatatgc cttgctgtca actccagccg gccaaacaaa 1153021 aactcacgaa tttcgccctc cagccctaca tggtccattg cgtccttcat acagctgagc 1153081 cacgcatcag ctctctcgtt tgtaattgga aagggaagat gccttgctct gagcatagga 1153141 tggccgtgtt cctcagtata aagaggaggc ccgcctaaat actgagttaa gaattgcttc 1153201 tgtttcctgg cggtttctgt caaatcgctt ggaaaaatcg gcttcagcaa aggatgagac 1153261 gcgacacgct cataaaaagt atcaacaagt tgcgatagaa gttcctctcc aatcgcttca 1153321 taaggtgcgt taaacgattg tcccatgttg actactcctt taaatatggc taataggaat 1153381 cataaatcct attgcaaaaa gtaattttct gtatttcatt gtttcatcta gatttatttt 1153441 agcaacaagg catcatttct acaaacaaac tgccttttat gcgtttgatg actcatttcg 1153501 gctgacagcc ggggtttgta tttcatatca tatcacataa aaatcaggaa tgcgtaagat 1153561 ttcacttcgc aaaaaaacca gagggaaaga gcacctctgg ttacgcgtaa taaactgaag 1153621 ttattttttt tacatagttt tgcgtttctt ggaaaggagg aatgcctccg tatcggtcaa 1153681 cattccccgg tccggcgttg taagccgcta atgccataga cacattgccg tcgtatttat 1153741 ccagcatttg ttttaaatat ttcgttccgc cctccacatt ttgctgcgga tcaagcggat 1153801 tggaaacgcc aagtgagctt gctgttgacg gcatcagctg catgaggccc atcgcacctg 1153861 ctccgctgac cgcttttgca ttaaagcctg attcctgttt gatgacggcg cggatcagtt 1153921 tttcatcaac gccatattta tcagcggctt ttttaatcgc actgtcaata gagaagtctc 1153981 ccgaacggat ctgatttgct tcatgtttgt ttgaagctga atctgcaaca gctgtttcag 1154041 tgctttctgc cgcttttgtg actgaacctg aattgctgct cgtatatgag ttaagcccat 1154101 acgctgaaag cagtgacggc gctgttgtat tcgcgctgtt cagcatgctg agcgggcttg 1154161 gcgatgaaga aggtgctgat tgctgagatg tcagaccgtt tgtatattgg ctgagcaaag 1154221 aactgaaact tgaaagcggg ctttccgtat tctgagtgtc cgagctgctg cgtgcattag 1154281 atatggactg taatgcctga agctgaagta atgctgccca attcgttaca ttcacgatgt 1154341 cattccacct tatatagact ttcgtttttc ttcataaaaa cgcagaattt tatttttggt 1154401 ttcgcgctga ggaatgctga attgctgaag cagcttttcg aaggcttgtc tgccctcatg 1154461 ccaatccgcc gcctcaaatt caatttcata gtcctcttta tttaaatatc ggctgtggtc 1154521 taaaactatt aagccttttt ctgtttcttt ttccgcacgg tttgttgcta aagatccaaa 1154581 gtattgtatg gcatccgtat cgatctgaag cttgtgcagc tggtccttca cagggccctc 1154641 gggaactgaa aatccagcga gatctgatac ctctgaaagc tgctggtgcg tttccagaag 1154701 ccccacatca gccggctcct ttaatgtaag gacatacttt ccgttttttc tgcggatacg 1154761 aagcgcagca tgtttttgtt tcagcgcgaa gctgtctgta tcaaaataat gattcttttg 1154821 atctgtaaaa tctttttctg tcagctggag tgccgatgct atgtttttga attcttgttt 1154881 ggtcagcatg tttttaaatt cgatttcaat ctcttggctc atgatgctct tcctttccgc 1154941 cctgtaaatc ttatttttac tattatctct ttagatgtta ggtttatcaa tatcgagctc 1155001 gatatgataa aatgaatctg tactttgttt aaaaaaggag agcattatgc aaaacagaat 1155061 cgaaattttg aatgcaacat tatcggatga tcagcttcgc cttgcctgtc agacagaagg 1155121 aaacgaagcg gaacgcaagc cgtcaggtca aatgcttgtt gattctgacc actttgcttt 1155181 tgtatacata cttgaattag ctgattcttt tgaatatgtc attataaagg aacatgtatg 1155241 gccggaactg aagcaggccc atgcacaaaa aataccggtt gttttagagg caggagacca 1155301 aacaattgaa ctggcaggcc tgcatgagga gctggaatat cttttagaaa atataaaaga 1155361 taatgcaaac tatggagaag aaatggaaga aaaagtgaaa cgcgtgtttt tatagaaact 1155421 ggttcggaat tgggggatgt atgatggatg acaaacaatg ggagcgtttt ttagtgccgt 1155481 accgccaggc tgtcgaagag ttgaaagtga agctcaaggg gatccgcaca ctatatgaat 1155541 acgaggacga ccattcaccg atcgaatttg tgaccggacg cgtcaagcct gtggcgagca 1155601 tacttgaaaa agcgagacgg aaaagcatac cgctgcatga aattgaaacc atgcaggaca 1155661 ttgctggcct tagaatcatg tgccaatttg tcgatgacat ccaaatcgta aaagagatgc 1155721 tttttgccag aaaagatttc accgttgtgg atcagaggga ttatattgcg gaacataaag 1155781 agagcggata ccgatcatac catcttgttg tgctgtaccc tttgcagacg gtatccggag 1155841 aaaagcatgt tctcgtagaa atacagatcc gtacactggc gatgaatttt tgggcgacca 1155901 ttgaacattc attgaattat aaatacagcg gaaacattcc tgaaaaagta aaactaaggc 1155961 ttcagcgcgc ttctgaagcg gcttcccggc ttgatgaaga gatgtcggag atcaggggtg 1156021 aagtacagga agctcaagct gccttttcaa gaaagaaaaa aggaagcgag caacaatagg 1156081 taaaggggaa gaagagcatg aaatttgccg tatcatcaaa aggagatcaa gtttctgata 1156141 cgctgaaaag caaaatacag gcgtatttat tggattttga tatggaactg gatgaaaatg 1156201 aaccggaaat cgttatttca gtcggaggcg acggaacgct tttgtatgct tttcacagat 1156261 acagcgaccg tttggacaaa acagcatttg tcggcgttca cacaggtcat ctgggttttt 1156321 atgccgactg ggttcctcat gaaattgaaa aacttgttct tgccatcgcg aaaacgccgt 1156381 atcatacagt cgaatatccg cttctcgaag tcattgtgac ctatcacgaa aacgagcggg 1156441 aagaaagata cttagctttg aatgaatgta cgattaaaag catcgaagga agccttgttg 1156501 ctgatgtgga aatcaaaggg cagctctttg aaaccttccg gggcgacggc ctctgcctgt 1156561 caactccatc aggcagcaca gcctacaata aggcgctggg cggagcgatt atccatccgt 1156621 ctatcagggc gatccagctt gcggaaatgg cttcaattaa taaccgcgtg ttccgtacgg 1156681 tcgggtcacc tctgcttctc ccatcccatc atgattgcat gattaagccg agaaacgaag 1156741 ttgactttca agtgacgatt gaccatttaa cccttctcca taaggatgta aagtcgatcc 1156801 gctgccaagt tgcatccgaa aaagtgcggt ttgcgagatt ccgtccgttt ccattttgga 1156861 aaagagtcca ggattcgttt attggaaaag gtgaatagaa agaggacata tcgtggagca 1156921 tttttttatc agaaagaaca ttacttccgc tgaggacggg atgactgtaa aagaatatgc 1156981 cggtgaactg ggaatttcga aacgtctgct gaccgatatt aagtttggcg ggggagacct 1157041 gcagattaac ggtgagcatg tgacggtcaa atacgttttg aaagagggag atcttcttat 1157101 cgtgaagttt cctgaggagc aggtgagcga gacgctgttg gcagagcctg ttccgctcga 1157161 tatcctttat gaggatgaac atgtgcttgt gataaacaag cagccgtatg tgtcatcaat 1157221 cccttcgaga gagcacccct ccggcagcat tgccaatgga attattgatc attatcaaac 1157281 aaccggagtg agggcgacag ttcatcttgt cacccggtta gaccgggata catcaggtat 1157341 catgcttgtt gccaagcatc gatttgccca ctccatttta tcgtctgcgc aaaaaaacgg 1157401 ccttgtgaaa cgccggtatg cggcagtggt tcacgggcgg atggcacaga tggagggaac 1157461 agtcgatgct ccgattggca gacatcctga cagtattatt gaacggacgg taacgccaga 1157521 cggccagaag gctgttactc atttttacgt cacatgtgca aatgatgaca tgacctcggt 1157581 ggcattgcag cttgagactg gacgaaccca tcaaattcgt gttcatatga gctatctcgg 1157641 gcacccgttg tgcggcgata cactgtacgg cggaacgaga caggaaattg gccggcaggc 1157701 tctgcacagc gagcatcttt cgtttatcca tccgctgaca caggagaaca tgaggtttca 1157761 tgctccactg cctcaggaca tgagcaaact gataaaagga gagaatcatt gattctctcc 1157821 ttttttatat ggggcgaaat cttgattcgt cgtaaggcag ggagcttgga acagagacgg 1157881 tttctatttc tggaaagcga aagcctgtca gttgatttcc gaacacgcag cctgtatcaa 1157941 tgttgatggt gcgattgacc ttccgaggct ctttcacagg tgtatgaccg tataccaccc 1158001 aagcctttcc gttataggct gccgcccaat cacgcctgat gggtctgccg tccggatatg 1158061 tttcacccgt cacgtcaccg taaagcacaa agtccttcac tctgcgggta tatttgccga 1158121 tatcgtcagc tcttatgcca gcatgggcga caactaattc tccattatgt aagatgtcgt 1158181 aaagcggcgc tgtttcgtac agcttcataa actgttcgct gactgatttt ttctcatctt 1158241 tggaaagttc ctcaagctct gccgctgttg tttcgagacc atgcatcact tttaccggat 1158301 ttccttttaa gtaacgatat aatttattgc aatggtttcc cgggacataa cgcacagcgc 1158361 ctttttcgta agcgccggct acaaatcgga tgacctctat cgatttgggc cctctgtcag 1158421 ttaaatctcc ggcaaaaaca agcaccctgc cttcttcatg gacaggtact ccatttttga 1158481 ttgtatagcc aagcttttgg attaatgcag tcatttcgtc atagcagcca tgaatatcgc 1158541 tgatgatatc gtaagccatg cggtctcctc cttaccgatt gttttattta ttatgaagca 1158601 aagtgttgtg agtcatcaca agcttttatg tgcaaattat agaagaagaa tcattttcta 1158661 aacaggatta agaccttatc actttatttt tcatcatcac ccttgttaaa atcgcgttat 1158721 gttttttaaa aatgaggttt tgttctctga gtgagaacta gcataaccct gacttaaaaa 1158781 ggaggttctg attatggcgc atacatctgt cgcatcttta gttgttgtac ttatcgttgc 1158841 atttttgaca cccatccttt tgcatcggtt taaactcagc atcccggttg ttgttgctga 1158901 aatcattatg gggctgataa ttgggaaaag cggccttaat ttagttgtgg agggtgacac 1158961 ctggctccag acactctcta tgctcggatt tatcttttta atgtttttaa gcgggcttga 1159021 aattgatttt tcgtcgtttg agaaaggaaa gaaaaagcag ttcctgccga atggcaagga 1159081 agcgccgaat acgtttgctg cggcatctgt tattttcgtc ggtattttta ttttatcatt 1159141 gctcttgtcc tatgggttcg tcttggccgg atttatccaa aatgcatttt tgatgaccct 1159201 gattatttca acgatttcat taggcgttgt cgttccaaca ttaaaagaag aacggatcat 1159261 gaattcgaat atcgggcaga ttattttgct tgttgctgtt attgctgatt tggccacgat 1159321 gattcttctt gctgtttttt cttctttata cggagaggac agcggaaaca tgtggctcct 1159381 gatgattctg tttgcggccg gagtggtgct ttactttttc ggccgggtct tcaaacatcg 1159441 ctcttttgtt caatccatgt caaaagggac gatccagatc gggacgcgtg ccatttttac 1159501 gttaatcatt gtactcgttg ccctgtctga atcacttggg gcggaaaata ttctcggcgc 1159561 tttcttagcg ggggttcttg tttccctgct ttcgccaaac aaagaacttg ttcagcagct 1159621 ggactcattc ggttatgggt tcttaatacc gattttcttc gtgatggtcg gtgtgaagct 1159681 tgatatttgg actcttttcc aggataaaac aattttaatc atgattccgc tcctgctgct 1159741 tgcgctgtta gtcagcaaaa tcattcctgt catgtactta aagaagtggt atgataaccg 1159801 aaccattttc gcgtctggtt tcctgctgac atcaacgctt tcgctcgtga ttgctgctgc 1159861 aacaatcggc cagcagcttc acgtgatcag tacaaatatg tcaggagcgc taattttagt 1159921 agccgtcatt gcaagtattt ttacgccgat ctgttttaaa aaattataca aacgggaaga 1159981 gcagccggag gagaaaaaga cgattacgtt cattggcgcc aatcaaatga ctttgcctgt 1160041 cacactcgaa ttgccagagg aagagtatga cgtgcgtgtt gtacacgtct accaagagaa 1160101 tgcggaggaa aagctgtcag aatcagtgtt tgctgttgaa acaatttctg actatgaaca 1160161 cgagacgctt gaatcactcg gcatttttga aacggatatc ctcgttgtgg cgacaggaaa 1160221 tgaagatatg aatgcagaca ttgcattact tgcaaaagat aaaggcacag aaagagtcat 1160281 tgcaagcgta ggatcaccgg agcatgaagc agctctgaag gagcagggaa tcagcatctt 1160341 ttctattctg ctgtcgacaa aaacgctgct tcgcgcactg attgaagcgc ctggcgtcat 1160401 gaagctgctc acgaaccaag agtcttcgct gtatcaaatt aatatggaga acagtaaata 1160461 tgatggtgtc attttacggg aattcccttt aacaggtgac gtcatctttg tcaggatctt 1160521 cagaggtgtg gacagcatcg ttcctcatgg ggatacgagg ctgaaacttg gagaccgttt 1160581 aattgtcacc ggatctcggg ggtacgtaac ggatcttaag aaaacattgg aaggataaat 1160641 cttgaccaaa taaggattcg tgttaatata gaggtgcaga acaattcaat atgtattcgt 1160701 ttaaccacta ggggtgtcct tcataagggc tgagataaaa gtgtgacttt tagaccctca 1160761 taacttgaac aggttcagac ctgcgtaggg aagtggagcg gtatttgtgt tattttacta 1160821 tgccaattcc aaaccacttt tccttgcggg aaagtggttt ttttattttc agagggggaa 1160881 tgatttgtga agttttcaga agaatgccgc agtgcagccg cagaatggtg ggaggggagc 1160941 tttgtccatc cgttcgttca aggaatcggt gacggaacgc ttccgattga ccgttttaaa 1161001 tactacgtac ttcaggattc ctattattta acgcattttg caaaggtgca gtcatttggt 1161061 gccgcttatg cgaaggatct ttatacaacg gggcggatgg caagccatgc ccaaggtaca 1161121 tatgaggcgg aaatggcgct tcatcgcgag tttgccgagc tgttggaaat cagcgaggaa 1161181 gagcgtaagg cgtttaagcc gtctcctacg gcgtactctt atacatccca tatgtaccgt 1161241 tcggttttga gcgggaattt cgcagaaatc ttagcggccc tgctgccatg ctattggctc 1161301 tattacgagg ttggtgagaa attgctgcat tgtgatccgg ggcatccaat ttatcagaag 1161361 tggattggca catatggcgg tgattggttt agacaacagg tcgaggagca aatcaaccgc 1161421 tttgatgagc tggcggaaaa cagcacggag gaagtgcgtg ccaagatgaa agagaatttt 1161481 gtcatctcca gctactatga atatcaattt tggggaatgg cctatcgaaa agaaggctgg 1161541 tctgacagcg ccataaaaga ggtggaggaa tgtggagctt cacgccataa cggatgacag 1161601 caagccggta gaagagctag cgagaatcat cattacgatt cagaatgaag ttgattttat 1161661 tcacattcgg gaacgctcaa aatcggcggc ggatattttg aaactgctcg atcttatttt 1161721 tgaaggcggt atagataaac gaaaattggt gatgaacggg cgcgtggata ttgcactttt 1161781 ctctactatt caccgcgtgc agctgccaag cggcagcttt tcaccgaagc agatcagagc 1161841 cagatttcca caccttcata tcgggaggtc ggtgcattca ctggaggaag cggttcaagc 1161901 agaaaaggaa gacgcggact acgtgctgtt cggccatgtg tttgaaacgg attgcaaaaa 1161961 gggtcttgaa ggcagaggag tatctttgct gtcagatatc aaacagcgga tttccatccc 1162021 ggttatagcc atcgggggga tgacgccgga caggttaaga gacgtaaaac aagcaggggc 1162081 agacggcatt gctgttatgt caggaatttt ctcttccgct gaacctttgg aagcagccag 1162141 acgatattcc cgcaagctaa aggagatgcg ctatgaaaag gcattatgaa gcagtggtga 1162201 ttggaggcgg aattatcggt tccgcaattg cttattattt ggcaaaggaa aacaaaaaca 1162261 ccgcattgtt tgaaagcgga acaatgggcg gcagaacgac aagtgccgct gccggaatgc 1162321 tgggcgccca tgccgaatgc gaggaacgtg acgcgttttt tgatttcgct atgcacagtc 1162381 agcgtctgta caaaggtctt ggagaagagc tttatgcatt atccggtgtg gatatcaggc 1162441 agcataacgg cggtatgttt aagcttgcat tttctgaaga agatgtgctg cagctgagac 1162501 agatggacga tttggactct gtcagctggt attcaaaaga agaggtgtta gaaaaagagc 1162561 cgtatgcgtc tggtgacatc tttggtgcat cttttattca ggatgatgtg catgtggagc 1162621 cttattttgt ttgcaaggca tatgtgaaag cagcaaaaat gcttggggcg gagatttttg 1162681 agcatacgcc cgtcctgcat gtcgaacgtg acggtgaagc cctgttcatc aagaccccta 1162741 gcggagacgt atgggctaat catgttgtcg ttgccagcgg ggtgtggagc ggaatgtttt 1162801 ttaaacagct tggactgaac aatgcttttc tccctgtaaa aggggagtgc ctgtccgttt 1162861 ggaatgatga tatcccgctg acaaaaacgc tttaccatga tcactgctat atcgtaccga 1162921 gaaaaagcgg aagactggtt gtcggcgcga caatgaagcc gggggactgg agtgaaacac 1162981 cggatcttgg cggattggaa tctgttatga aaaaagcaaa aacgatgctg ccggctatac 1163041 agaatatgaa ggtggatcgt ttttgggcgg gactccgtcc gggaacaaag gatggaaaac 1163101 cgtacatcgg cagacatcct gaggacagcc gtattttatt tgcggctggc catttcagaa 1163161 acgggatcct gcttgctccc gcaacgggcg ctttgatcag tgatctcatc atgaataaag 1163221 aggtcaacca agactggctg cacgcattcc gaattgatcg caaggaggcg gttcagatat 1163281 gatgctacag ctgaacggta aagacgtgaa gtggaaaaaa gacacaggta caattcaaga 1163341 cctgctggcg tcgtatcagc ttgaaaataa aatcgttatc gtggaaagaa ataaagaaat 1163401 aatcgggaaa gaacgctatc acgaggttga gctttgtgat cgtgatgtca ttgaaattgt 1163461 ccattttgta ggaggcggat gagcatgtta acaattggcg gaaaatcatt tcaatcaaga 1163521 ttgctgctgg gcacggggaa atacccatcg tttgacattc aaaaggaagc agtagctgtt 1163581 tctgagtctg atattttaac atttgctgta aggagaatga acatttttga agcatctcag 1163641 ccgaattttc tggaacagct tgatttatcc aaatatacgc ttttgccgaa tacagcgggc 1163701 gccagtactg ctgaagaagc ggttcggatt gcaaggctgg cgaaagcttc aggcctttgt 1163761 gacatgatta aagttgaagt catcggatgc agccgttcct tgctgcctga ccctgttgag 1163821 acattaaaag cgtctgaaca gcttcttgaa gaaggcttta ttgtgctccc gtacacgtcg 1163881 gatgacgttg tgctggcgag aaagctggaa gagctcggcg ttcatgccat catgccgggt 1163941 gcatctccga ttggatcagg acaaggaatc ttaaatcctt tgaatctgtc gtttattatt 1164001 gaacaggcga aagtaccggt catcgtggat gcgggaatcg gctcgcctaa agatgcggca 1164061 tacgcaatgg agcttggagc ggatggcgta ctgctcaata cggctgtatc tggcgctgac 1164121 gatcccgtga aaatggctcg tgccatgaag ctcgcagtgg aagcagggcg cctttcttat 1164181 gaggcgggcc gaatcccgct taagcaatac ggaacggcaa gcagtccggg agaaggtctt 1164241 cctgtatgac aggcaggtat tcaaggcagg agctgtttgc tccgatcggc ccatccggcc 1164301 agaaaaaatt gaaagaagcg cgcgccgtga ttatcggcgc cggcgcgctc ggaacagcca 1164361 gtgcagaaat gctggtgaga gcgggagtcg gctctgtgaa aattgccgac agagattatg 1164421 ttgaatggag caacctccag cgccagcagc tttatacaga agatgatgtc aaaaaagaaa 1164481 tgccgaaagc agccgctgcg gagcgccgtc tccgttcgat taacagcgat gttgatgtga 1164541 ccggccttgt catggatgtg acagcagaaa atatcttcga gctgattagg gatgcatcga 1164601 ttattgtgga tgcggctgat aattttgaaa cccgcctgat cgtaaatgat gctgcggtaa 1164661 aggaagggat tccttttctt tacggtgcct gtgtagggag ctacggtctt acctttaccg 1164721 tggtgccggg ttctactcct tgcctgcatt gcttgctcga tgcacttccg attggcggag 1164781 caacatgtga cacagctggc atcatcagtc cggctgtttt gcaggtagca gtctttcagg 1164841 taacagatgc actgaaactg ctgacgggag aggagtgcga gccggtgctg cgctcctttg 1164901 atttgtggaa aaacgagcgg tcagaagtga gagcggccag tctcaaacat gacgcatgcc 1164961 caagctgcgg cacaaaggat tttccgtttt tgtcttatga aaatcaaaca aaagcggctg 1165021 tattgtgcgg caggaacacg gtgcagatca gatcatctat tacgaaagaa gcggatcttg 1165081 aagcgcttgc cggtcagctg aggcaggccg ggcttgaagt agctgcgaac ccgtatttaa 1165141 tttcctgccg ctcggatgat atgaaaatgg tgctgttccg ggacggcaga gctttgatcc 1165201 atggaacaaa tgatattgcc cgggcaaaat ccatttatca taaatggatt gggtaataaa 1165261 aggagtgtag tgtaatgagt atatataaag cattgacaat cgccggatca gattcaggcg 1165321 gcggcgcagg gatacaggct gatattaaaa cctttcaaga gcttgatgta ttcggaatgt 1165381 ctgcgattac ggcggtaacc gctcaaaata cgcttggcgt tcacggggtg catccgctga 1165441 ctgtagagac gttgagacag caaattgacg ctgttgctga ggatttgaga ccggatgcag 1165501 ttaagacggg aatgctctgg aatgccgaca tgattgaaga agtggcaaga aaaattgacg 1165561 agtacggatt caatcgtgta attgttgatc cggttatgat cgcaaagggc ggggcatcct 1165621 tgctgcgtga tgagtcagtt gccaccttaa aggagttgct cattccaaga agctacgcga 1165681 ttacgccgaa tgtcccggaa gcagaaacgc tgacaggaat gacaatcagc tcgctggatg 1165741 accggaaaaa agcagcggag cagctcgtca agatgggtgc gcagcatgtc attatcaaag 1165801 gcgggcacca gcctgaggac aatcacatta ctgaccttct ttttgatggc agcatgttta 1165861 tgcaaatcac ccatccttat atcaatacga agcatacgca tggcacaggc tgcacctttg 1165921 ctgcggcttt aacggcccaa acggctaaag gagacagcat ccatcaggca tttgaggttg 1165981 cggccaactt tgtccgtgaa gcggtggaaa atacgctcgg catcggatcg ggacacgggc 1166041 cgacaaacca tttcgctttt aaacgaaaca gcttaaatac aagccgatga gatcaccagc 1166101 tgatggtgat ctcttttgcg tttgctacgg tatgcgcttt tcatctggac aaggttatga 1166161 tatgatagga attaagatca ggtactaata ctatgtcttt attaaatata ggaggcttta 1166221 tacatatgaa tttttcactt gaaggccgta acattgttgt gatgggggta gccaacaaac 1166281 gcagcatcgc ctggggcatt gcgcgttctt tacatgaagc gggtgcacgt ttgattttca 1166341 catacgctgg tgaacgcctg gagaaatccg ttcacgagct tgccggaaca ttagaccgca 1166401 acgattccat catcctccct tgcgatgtta caaacgacgc agaaatcgaa acttgcttcg 1166461 caagcattaa ggagcaggtc ggtgtaatcc acggtatcgc gcattgtatc gcgtttgcca 1166521 acaaagaaga gcttgtcggc gagtacttaa acacaaatcg tgacggcttc cttttggctc 1166581 ataacatcag ctcatattct ctgactgctg ttgtcaaagc ggcacgtccg atgatgactg 1166641 aaggcggaag cattgtcact ttgacgtacc ttggcggaga gcttgtgatg ccaaactaca 1166701 acgtcatggg tgtagcaaaa gcttctcttg atgcaagtgt gaaatattta gctgctgact 1166761 taggaaaaga aaatatccgc gtcaacagca tttctgccgg cccgatcaga acattatctg 1166821 ctaaaggcat cagcgatttc aactctatct taaaagacat cgaagagcgt gcaccgcttc 1166881 gccgcacgac aacacctgaa gaagtgggcg atacagctgc gttcttgttc agcgatatgt 1166941 cccgcgggat tacaggtgaa aatcttcacg ttgattctgg tttccatatc actgcccgct 1167001 aagcaggatc tatatcaagc aatcccgaat agggattgct tttttatttc ttctgatttt 1167061 cagctttctg tcatatagat agaatatgac acaatcggag ggatgaagat gtctaataag 1167121 aaaagaaacg cggataaaaa accgctcatg tatattgttc agccggatta tgcagaaact 1167181 acaaggtcat ccatgcagga gattgtcatc aaaagaaagg ccgacaaacc cgctccgcca 1167241 aaagctgagg aaaagccggc ttaccatgag aagcagcagg aggaagccgt ggcacaggat 1167301 gtcctgcaag aagaccaaaa gcctgcagcc gaaccagtga gtcagcaaac acaagaggcg 1167361 agagagccag agaacataaa aagccaagag gaacagaagg cagagccgca ggccgtagaa 1167421 gaaaccgttg aacacgagcc cccgaaagca gaaaaaaagg aagagcctgc acttgaggcc 1167481 cggaagcctg agaaagaacc ggaagctgtc catagtgctg ataaagcgga ggaaaaagca 1167541 ccgccggcac gaaaagtgaa aaaaccgatg agcaagatga cgatccacga aaaaattgat 1167601 tttttaacaa agctgcctca taacatgccg agagcgcttt gtttgattga agccaatgga 1167661 agaacgtaca ggggcgtgat tgtcggaaga agaaatgatt ccgtcctgct tcgaacaacc 1167721 ggaaacggag ccccaaccga actggcaatc gatgatatta cctctttgca cccgctcggt 1167781 ttttaacgaa aaagaaaaaa gctgcccggc tgatgttgcc ggacagcttt ttttacatag 1167841 agaaaagcct gcaggcctgc aagcttttcc agcttatgat taatgatgat gtgtacgatt 1167901 gattaatcga ggatttaagc agttgattgc gcagaagcag tctaagtcaa cttcaataca 1167961 gtagttcgtt ttttcgagtc ggaacacttc acacaccgta tctttatcgg tgaagtccaa 1168021 aatgtgtttg tgttcgtcaa atgcgattaa taatgacagt gttgcacagc ttccatgcac 1168081 tctttcgacc ctgaaaaata ctgtattaaa gcaagggccg ttatcgagtt cgccgacatt 1168141 tccgaaggcg actaatggcg ttgattttga tgtaaatatt gcaaaaggca ctgtgtcgcc 1168201 taacgaatgg cttacagata aaagcttaga gtggcagccg gtcgggcagt cttcttcaac 1168261 agcgttttgc agatcttcaa tattttctac agcttcacgc acgcagcttg atgttttctg 1168321 gctcatatta tccctcctgc cttataaatt tgagactggc gaaatgatgg agagtcagct 1168381 gcctcacgct ggaagcagct gaatgatttg cacctgtaat agagtttgga aggggattcc 1168441 tctttacaag tgtttatcca ttgtgatgat gctttttatc tttgtgaggc gatgttctgt 1168501 caactagctc tggtgacagg cactgaatcg cgcagaagca tccgagatcc acttcaatgc 1168561 agaaatctgt tttttctagc ccgaagaaat ccgggtcgca agggtggcaa acacttaagg 1168621 tatcgccttt gacatcgacc gggcgtaaaa tagacagtgt tgcacagcaa tcgcataatt 1168681 tttcgacgcg gaagaaaatg gattcaaagc attgcatatc atccacaaat ccccctacgt 1168741 ttccgaatgt ggagaacaat ccgccttttt tatcaaaaac gagaaacgga attgtgtctt 1168801 ttccagcaat cgtagggttt aaaaggttgg tatagcagcc agtcggacac tgttcttcaa 1168861 ctgcctcctg ctctgctaaa atcttttcca ctgcatcgca tacacagttc tcatgccggc 1168921 catgggtttt tccgcagctc attgatttca gctccttctt tatagggtat ttgactttag 1168981 tccttaacaa catatgtacc cgtgccccac ttggtgtggg tgaacgtcta tatattcatc 1169041 atatgcttgg aaaataagaa aaagcagagc gtttttagct ctgcttttag gtcctagagg 1169101 acaagagtga taactaggat ggctacgagt gtatttgttg ctgtagaaat aagggttgcg 1169161 atatcggcat ctactgttgt gacgtttacg ccgcgggaac attcgatgag aagtttttgg 1169221 cggtttactt gtttgttagc tgtaagctgt aacaaatctt gtgcgactaa ttcggcaatt 1169281 acgccgtctg caattgatgt cagagttgcc gttacgacag cggcattaag tgctgttaca 1169341 actgatgtta cggcttgaac gtctgtagat gtaacattga tgtcacaaga atctctaata 1169401 ataatcgttt catctgaaac ttgtttgttg agatttgctt gagctagatc ttggtcgatg 1169461 aaggcgttgt cgttgccaaa aaaaccattg ccattacagc aaacgtcgca atgacatttt 1169521 ctttcgtgtt tttctttatc tttctctttg tcatctaacg gatggtcaca gtcaggatca 1169581 agtgcaaccc aagaatatgg tctgctttcc atatctattc ctccttttct tttactgtta 1169641 ttaaatgagc gagcctctta ttttgactga gtcatatatc ctgatgaaga accctatttt 1169701 ttatgattgg ctaattgtta tcgtttttcc gtctttgtct gatctgttca atgagctgct 1169761 ctctgcggct taacggtttt gtgttctttt gctcttgtgc ggctgcttct tcttttttct 1169821 tcttttggtt ttctattagc gcttgtgatt tagcttgtaa gtcttttaca agatttaaga 1169881 gcatttcttt ttcttcgtct gatacttttt tcattttgtc ttttgtgacc ccatgtttag 1169941 aaaatatatt ttggaccagc attttcgtca ttggatcaac ttctggaagc tttgcaagct 1170001 cttctttgaa tttatcgtta tctgacattt gttttcacct cgtcttttaa gtttgtgaaa 1170061 agaaagggtt aaaggacgtc aagttcacta agaatgctgt ttaacacctg aagcaagatt 1170121 tgtacaaagg ttattatctc gtcggcagac aaagtaattt tgatgttgcg gctgttgata 1170181 attttaatga tggttctttt tttgatttgg gagctatcga gaataagaat ttcacttgcc 1170241 actgcgtcag ccaaatcctc gtcggcgatg acgagctgag tcgccacgat aatcatggtt 1170301 gtcacaaagg cttgtataga aagggcagct gttatatgtg acgtgtcaat tgtgatattt 1170361 tcgcaatcaa tcacttcgat ctgctgttcg aattcgcttg ataattgctc aaatattgca 1170421 gggtgcaggg attcgacttt ttcttcaaat gacataacct tcactccttt cttatccata 1170481 ctctatataa tgcaaatggg gtgcagagcg gaataataaa aataaccaat tttctgccgg 1170541 acaagataca attcatgaag aatagggttt tggcatatat gtgaagggat catgattggc 1170601 aaaggagtga acgagtggtt ataaatgggc tgacaattgt tcttctatcg cttgcggtct 1170661 ttcggctcgc ccgcctgctg gtgtttgaca cgattatggc gccgcttcgc agtctgtttc 1170721 atgaagagaa ggaagaaaag gatgcggacg ggaacattga aacctatatc gtgattaagg 1170781 gaaccggtgt cagggcgttt attggtgaat tgctgagctg ctattggtgc acaggcgtgt 1170841 ggtgtgccgg ctttttgatt ttatgccagg cggtgatccc gcaagcggcg cagtggctga 1170901 ttttactttt ggcgatcgcc ggccttgccg gcattataga aacgctcgta tcaaaatggc 1170961 tgcaagaata aggcgttacc accagcaact ttctgtcaga atacgcataa agtagcatat 1171021 atgacataag gaaaggaagg ggacaaaaat gaatcagcat cataaacctt cccaaaaatc 1171081 tccatataca gattcatcgt atcaatcaaa aaagataaaa aagaaaggct gcgggtgcgg 1171141 aaataaaaag aaaaagcctc aatagcctgg caaagaaacc ggagaactcc ggttttttgt 1171201 ttttttaacg aggcggtctc gctcagcata tatcataagc ggggggataa aagtgaatga 1171261 gtttgaaaaa tggatagaag gaagatatga accacatgaa caaaagcaaa aagagcatga 1171321 agacacgatg ggcagtatca gaaaagactt ggatgcattt gataaagccg gtctggaatt 1171381 tgaagatgag attgaagagc tggctgaaaa aacggaggcc ttacttaaaa aacatcaagc 1171441 tcaatatgat caatcgtaaa tccgcaaacg ccctatgcga atatccaagc cgatcccagc 1171501 agctcacata gtgtatagag agtaaaggag gtgcttatct atgggctttg gatacggatt 1171561 cggcggcggc tacggcggcg gctgttatgg cggttatgct ggcggttacg gcggcggcta 1171621 tggttcaaca tttgttttgt tggtcgtatt attcattctc ctcatcatcg taggtgcatc 1171681 tttcttttaa gatgtattga ggaagtacgg gttataaccc gtacttcctt gccttgtgtt 1171741 tatttttaaa aatgttggaa aagcacattg tattatgtgc attcatacaa taccgtatta 1171801 ctccgccaaa aggaggcgca ttatggataa tcaatttttt aagaacatcg aaaagaaaac 1171861 aggtgtgaag atgcaggatg taatgaatct tgccggatca ctccaaaacg ctaattttaa 1171921 agatgaaaat acagtgcgca gtgtgattaa ccgcgtagcg cagatggcaa acagacgcgt 1171981 gccaaaagaa ttagaagata aaattgtgga atctattaca agcggaaaag aaaagcttga 1172041 ttttggcacg atttctaaaa tgatggataa taaataagtg gatggcctgg ctgactcact 1172101 gcagcgggcc tttttttaca gtaaaaaccc ggcagtaatc tgccgggctg ttaatgatgc 1172161 aagggctgtc ttgctttctg tagcagggga tacaaaaatc ttgagcggtt ggctgttttg 1172221 ccgcgcctgt tagcagggca agacaaatat aaatgctgtt tcgcccgggt catggctaca 1172281 tataaaaggc gtctttcctc ctcaagagcg gcctcgtctc cttttcttgc cgtttctaat 1172341 gagaaatcgt gcggaatcga gccatctaca gtgcctaaca cgtagactgt tttgaattca 1172401 aggccttttg accggtgaat ggtcatcagc tgaacgccat gttcatccgt tctgtttttc 1172461 tcagcggccc tcatatggtc tacgtgggca agaaagtcag gaatcgtttt gaacttcttg 1172521 gcgacaacct tgatgtcgcg caggtcatca gagccttttt ccagcttgtt gccctcattg 1172581 ccccgctttt ttaaatactc ggagaagccc atttttcctt ctgcaaaggt gatggcttct 1172641 acgggtttca ttgtgcggag gcttgcaaaa aacggtacga ttttcttgat tttgtccagc 1172701 tggaatggct tcagatcagg caatttggcc agcgctttga tcatggtaca gtcctctgta 1172761 atcgagagcg ccttcagcgt attcaaagcg gactgtttta aaaacaaggc gggaagcaag 1172821 tgtttaatcg cctcggtgtc atcctcattt tggctggcgt acaagtaggc gagaatctgg 1172881 cggacgatcc gtctgctgta aaacgattgg acgccgcggt cagctgtata cggaattgac 1172941 gattgatgaa gcctttcata tatagcacgg cctccgctgt ttgtgcggta aagaaccgca 1173001 aagtcttctg gactggctcc attttgaatt ttttctttga tatcggaaac gaccattgtg 1173061 gcttcttcct cttcatcata aggataaaac agcacaggga cctgaatgtc atcgcgggcc 1173121 gcttcaagcg ttttggcata tctgtttttg ttctttttca caacgatatc agcactagag 1173181 acgatcgggt gcgtagacct gtagttcgca gttaaataga tcgtcttcgc tcccggataa 1173241 tccttttgaa aatcaagaat gaaagacgga ttgcttccgc gaaacgcgta gatggactgg 1173301 tcatcgtctc cgacacagca caggttttgc tccgggctgg cgagcatttg catgattttg 1173361 tattgaaccg gattaatgtc ctgaaactca tcaattaaga tatacgtaaa ccgagattga 1173421 tattgttcca gaaggtcagg ccgctcgata aacaattcat agcaggctga agccatgtca 1173481 tcaaaatcaa attggctgtg ttcttttttc tggcgttcat aatgttcata taaacgataa 1173541 acttgttttt cccactcatc ttttagaggg atgcgttcat ttgggacata agtgtttttc 1173601 caaaaaccga tctgctgcag ggcttggtca actggggatt ctttctcatc gatgccttct 1173661 tcatagagtg cttttttgat atattgttcc cgctgccact ccattttcag cagatgctca 1173721 ccgttccatt tagcagaatt agagtgatac aagatcttat aaaacagact gtggaatgtt 1173781 cctgtcacaa ttcttctgac ttttgccggc tgtaatccgt actggttcgc catacgctct 1173841 ttcatttcag cgacagcttt tgttgtaaag gtgacaagca gcatattttc aggcggtatg 1173901 cctaagtgtt cgatcatgtg ggcggcacgg gctgtcagta cccgtgtttt tccgctcccc 1173961 gcacctgcaa gcacgaggag cgggccctct gtttccgtga cagctttcag ctgatccgtg 1174021 tttaaaccga cagacggaaa aaggctcgta tcgggttcta ttgtttttgg cacaaatggt 1174081 gttcctggtt taatgcttct aggacggtgc cattctgtaa cagctgggga cgggtcagcg 1174141 gcgatcgctt ttcccttggg taaacgaatg acaccagatt cctgatcatc ttcttttttc 1174201 ccctctttag agggcttcgg ttcgcacgcc tcctcacatg ccggaaaatc gcctggctgg 1174261 cgatggataa actctggcgg atcggcgatg ttaagccgta acaaaacggg ctttccgcaa 1174321 tgagaacaaa ataaatgtcc ttttattccc tcttcaaaga ggaattgata atgttctctc 1174381 gaatatgtat gtaaatgtat gattctatca ttcagtcggg cgcatttcaa aaaggggtcc 1174441 tcccaatcaa aaggtgttca ttacagacaa tgactatcat atcaaaagaa atgtgtttca 1174501 aaaagtaagt ttaagggaaa agagacagca gaggggtggg tattgtatga tatatgcagg 1174561 tcaaattcag aaccagcaat acgctcaata tgctaataga acgattggac ataagcagga 1174621 ttatgccgga accgaaaaaa tcagctatgt cccgtttcag cgggtataca aagaactgga 1174681 aaagcagcag gagaatcaaa cggcagctga aagaaaagta aacgagatga aacgtaagcg 1174741 ctctctttat aagagattgc gagaaaaagg aatggggaca tatattaatc gatatgtata 1174801 aaaaaccgtt cataccagag aacggttttt ttatatgcag taaaaatccg gatctcaaaa 1174861 gatccggatg cgttcagtcc ttcatcattt gtaagtgcgg aatgccggca tcgaggaatt 1174921 ctttttcaga aagcacgcga tacccgtgtt tcttgtaaaa cggcacagcc tgtgtttgcg 1174981 cgtttaaaat gaaaccggaa gcgcctccgt ctgccgcggc tttttcgagc gctttcataa 1175041 tgatgccgcc gacaccggct gagcggtggc ttttcagtac gcaaatccgc tctaacttgc 1175101 cgtagccgtc cttcatgcgc catcttccgg caccgacagg cttttcaccg tcatacacga 1175161 cgatatgctc tgactcattt tcaagttcgt caatttcttc ttcagcaggc acgttttgtt 1175221 ctttgacaaa gacttcttct cttacataga atgcatcttt cagttgttct tcattttttg 1175281 cgataactgc tttcaaacat tattctcctc tgcctagcaa gaaggtttca tatactgtcc 1175341 acgatccgtt ttccaactgg tagagcaagt ggaaacggtc aacgatttct tcatgcgaca 1175401 cttcctgcat ttttaattgt cccagcacat ctgaatgctc atcgtcggaa agattttggc 1175461 cgaccgtcac atgcggaacg aaattatatt cctgttctcc tgccaacaca ccggtgtata 1175521 gcttttcatt gagtgttttt aactcttccg tcggttctgc tttgatgtaa atgacattat 1175581 tgacaggcgc aaatgagctg tattttgtca ttttgagaac gagtgggtgg gactcttttg 1175641 cgatgtttct taaatgtgat acgagctgat ccgctttctc ctccgcgcat tcaaaggatg 1175701 ctctcagcgt caaatgaggc gggattagag agtagcttgg gtcatagcgc tttctgtaag 1175761 agtttgcaag gtcttggagc ttttttgatg gaaataaaac gattccgtat ttcatattat 1175821 gtccctcctg gaaataaagt atgatagagt gttaaagcat ttttttcagc gccggggtga 1175881 tgagcggctg ccagtatgtc catttgtggt ctccgtcaaa tggctcgaaa tcataatcgg 1175941 aaagcttttt ctccagcagc tgtttcagct cccggttcgg ttctgtaaag tccagaatgt 1176001 tcccgtctgt cgtgtggacg tcagtttctt ttgttccgat ttggtgataa atagagaggt 1176061 gtttgatatc gtctgactgt tttacggctt ctagtacgtg tttgtcaaca tagggagact 1176121 gcatgatgat gttgccaaac atattcggat aatcaagcgc tgtcataagt gacacggttg 1176181 ctccgagcga atcaccgatc agcgttcggc cgtaaccgat ctgataggtt ggatactcat 1176241 catctgcaaa aggaacgagc tcatgggcga tgaaccgttt ataagccgaa aattttgaac 1176301 cctccggatg ataagtgttt ctgcgctctt ttacatcctt atagggaaca ccgataataa 1176361 tgctccggtc tatttcgcgt ttcgacagca attcctcaac ctgtctgccg attctcccca 1176421 gcctgaaata atcgtggccg tcctgcgcga taatgacatg gtatttataa agcggggagt 1176481 agttggacgg cagataaaca agcaaggtca tttcctcgtt aagctctttt gaaaagaatt 1176541 tcttttcttg cactgtgccg tttttcggtg ccataaaaac attcctccag gacatcacta 1176601 tactttcttg cattttcaat tattgtacca tgaattatta gaaatttctc tctttaaacg 1176661 gttcggcaca cgaagaaaaa agtgttgaaa taaactgtga attgcgctaa tataaaacaa 1176721 tcagaaaatt gaaatcgata tttcttatcg tgagaggtgg agggactggc ccttagaaac 1176781 ctcagcaacc ggcttgtttt gcatttgcaa agcgccaagg tgctaaatcc agcaagcgtt 1176841 ttttatgctt ggaagataag aagaagcgtt aaaccccttc ttcttatgaa gaaggggttt 1176901 ttattttgaa aagggaaggt gtcagctata tgtcacagca cgttgaaacg aaattagctc 1176961 aaattgggaa ccgtagcgat gaagtcacgg gaacagtgag tgctcctatc tatttatcaa 1177021 cagcataccg ccacagaggg atcggagaat ctaccggatt tgattatgtc cgcacaaaaa 1177081 atccgacacg ccagcttgtt gaggacgcga tcgctaactt agaaaacggc gcgagagggc 1177141 ttgcctttag ttcgggaatg gctgctatcc aaacgattat ggcgctgttt aaaagcggag 1177201 atgaactgat cgtttcatcg gacctatatg gcggcacgta ccgtttattt gaaaatgaat 1177261 ggaaaaaata cggattgact tttcattatg atgatttcag cgatgaggac tgtttacgct 1177321 ctaagattac gccgaataca aaagcggtgt ttgtggaaac gccgacaaac cccctcatgc 1177381 aggaggcgga cattgaacat attgcccgga ttacaaagga gcacggtctt ctgctgatcg 1177441 tagataatac attttataca ccggtcttgc agcggccgct tgagctggga gctgacattg 1177501 tcattcacag cgcaaccaag tatttaggcg ggcataacga tctgcttgct ggacttgtcg 1177561 tggtgaagga tgagcggctc ggagaggaaa tgtttcagca tcaaaatgca atcggcgccg 1177621 tcctgccgcc atttgattcg tggcttctga tgagaggaat gaagacgctg agcctcagaa 1177681 tgcgccagca tcaggcaaac gcgcaggagc ttgcggcgtt tttagaagag caggaagaaa 1177741 tttcggatgt gctgtatccc ggaaaaggcg gcatgctgtc cttccgtctg caaaaagaag 1177801 aatgggtcaa tccgttttta aaagcactga agaccatttg ttttgcagaa agcctcggcg 1177861 gggtggaaag ctttattaca taccctgcga cccagacgca catggatatt cctgaagaga 1177921 tccgcatcgc aaacggggtg tgcaatcggt tgctgcgctt ttctgtcggt attgaacatg 1177981 cggaagattt aaaagaggat ctaaaacagg cattatgtca ggtcaaagag ggagctgttt 1178041 catttgagta aacacaattg gacgctggaa acccagctcg tgcacaatcc atttaaaaca 1178101 gacggcggaa ccggggcagt cagtgtaccg attcagcacg cctcgacttt tcaccaatct 1178161 tcatttgaag agttcggggc atatgattac agccgctctg gcacgccgac aagaacagct 1178221 ctcgaagaaa caattgccgc actggaaggc ggaacaagag gatttgcttt cagttcaggc 1178281 atggctgcca tctcaacagc atttttactg ctgtcacagg gtgatcacgt tcttgtgaca 1178341 gaagatgtat acggcggaac cttccgtatg gtgacagagg tgctgacccg gtttggcatt 1178401 gagcatacgt ttgtcgacat gacggatcgt aatgaagtgg cgcggagcat caagccgaac 1178461 acaaaggtca tttatatgga gacgccatca aatccgacac ttgggattac ggatattaaa 1178521 gcagttgttc agcttgcaaa agaaaacggc tgcctgacct ttctggacaa tacattcatg 1178581 acgccggcac tgcagcgtcc gcttgatctc ggcgtggata ttgtacttca cagcgcgaca 1178641 aaattcttaa gcggacacag cgatgtgctc tcaggtttgg ctgctgtcaa agatgaagag 1178701 cttgggaagc agctgtataa gctacaaaac gcgttcggcg ccgtccttgg cgtgcaagat 1178761 tgctggcttg tcctgcgcgg attaaaaaca ttgcaggtcc gtttagagaa agcgagtcaa 1178821 acagctcagc ggcttgcgga atttttccag aagcacccgg cggtcaagcg cgtgtattat 1178881 ccgggactgg ctgatcatcc cggcgctgaa acccataaaa gccagtcaac gggagcgggc 1178941 gccgtgctat cttttgagct tgaaagcaaa gaggccgtta agaagttagt cgagaatgtg 1179001 tcactcccag tcttcgctgt cagccttggc gccgtggaat cgattttgtc ctatccggca 1179061 acgatgtctc atgcggcaat gcctaaggaa gagcgtgaaa aacgcggtat cactgatggc 1179121 ctgctccgtc tgagtgtcgg cgtcgaacat gcagacgatt tagaacacga tttcgaacaa 1179181 gcgctgaaag aaattgctcc agtttcggtt cgttaaaaaa gaagccgggg atagtccggc 1179241 ttcttttatt attgttcgtc atcaggattc agaatcgcga ggacttgatg atcctcccaa 1179301 acgccattaa tttttacatt ttttcgggcg atgccttctt tatgaaatcc cgctttttct 1179361 aaaacacgca tggacccgag attacggggc atcacaccgg cttcaatccg atgcagtttc 1179421 aattcgtgga acgcataatc aacaaccaat ctgactgcct ctgtcataat gccctttcca 1179481 ttatgggctt tgtctaaaaa atacccgatg aacgcagttt gcagcgcgcc acggatgatt 1179541 tgaaagagcg aaaccgtccc gattaatcta tcgtctgacg ctgtaaagat gccaaaatga 1179601 tattcttcat ctttctcaag tctttcctga tactcggtta ttcgttttct ttgcccctca 1179661 accgtatagt aatcgtctgc gcgtatcata gaaaactgtt cgaaaaaatc tcgattttcg 1179721 ctttgcagcc ccagattttc ttcggcatcc gttacttcta aaggtctaac ataaatggtt 1179781 tttcctttta acatatagtg atctctccgt tctcatgtca gcattcctct tacattattc 1179841 tcagggaaat gcaaatatcc tttttataag aaggaagaaa accaatttcc cataaaagtg 1179901 ccaacatagt tgccgattaa gtagccgagc gtaccgacaa gcatgatcgg ggcgacaagc 1179961 tcccgccatc ccttggcaat tgccatcgca gccgcagtcg tcggtccccc gacagtagcg 1180021 ttgacggcga gcagaatttc ttcaagccgc acacggaaca attttccggc agctaaggaa 1180081 accgctaaat tgctaatcgc aatgataaac acgaataata gaataagagg cgcattcgtg 1180141 acgattaagc ggagatctgc aggaatgccg atcaccacaa aaaacaaata aatcaaaaag 1180201 gttccaagct cctgagatcc attgagcctt tcaaaaaaac gcgggaaaag aaaaatgata 1180261 agaacagtta aagacgtaag aaccaggtac tgatcgccaa gcgtaccggt cagcagggga 1180321 tgagaaaaaa tgcttttaaa ataaccggaa accttcatac taaccgcaac aagcgcgaaa 1180381 gcggcaccgg cattaaaagc gatatccttt aaggaaatat ccttccgttt ccaatagctt 1180441 tcagcactgt ttccgctgtt tccatcggct tttaccttct cttcaaacgg catggcataa 1180501 tgccgctgaa accatttgag tgcaggaatg ctgattaaaa taaaaaacaa aagcgccatc 1180561 ataaaattat cagccacaac ggtagccgac acatattcac caggcgtctc aaattttgcc 1180621 gccatcgccg caaagttgac cccgccgccg atataagagg cgctgatcat cccaccgatt 1180681 ttatctaagt aaggaatatg ctgtttgagt agaaaaaaag ccaggatact gccaagcact 1180741 gttccaacgg agctaatcag aaaaataaac agcaaacgcc tgctttcctt aaaaatttgc 1180801 ctaacattga tctgaaacaa taaaagtggt atcgccagcg gtaccacata agaccacaca 1180861 gtgtcataca cgggcgactc aacaggaagc actcctacat ttgtaaacac catagcacct 1180921 gcaagggcga taatagcgcc cgacacagca gacgcccact taaagcgctg ctccagcccg 1180981 atgctcactg ccgcccacac cgcaataaac ccccataata cccatacatc atcagaagaa 1181041 atcaaagaat gcaaaacccc atcacctcta ttgttagaaa attaagacat attataatag 1181101 ccggggaacg gaacagcaag tccaaaaaaa gtttttctaa aaaagcagtt gacgaataga 1181161 aggtaaggtt atataataga acttgtcaga aagataacaa catacccagc aacacataca 1181221 tatcatgatt ccgtagctca gctgggagag cgctaccttg acagggtaga ggtcgctggt 1181281 tcgagcccag tcggaatcat agcttaaacc cttgcgcagc aagggttttt tactttgcgt 1181341 taataaagcc ggttcgtcaa attcgtgagt tgttggcgaa ctgttggcga aattcattga 1181401 ccgcagtcca aaaactacct ccaaacttac ttgattagtt caatagtaac aaacggaaga 1181461 tcggatttct gttaaatctt cattgagaat agccagtcca agaccgtcac ttcagccatg 1181521 catcttttaa atgaaatttt gtactgaaaa catcaattgt atttttaaat tctgctctag 1181581 aatcagcccc tttataataa tcttgataaa ttgcttgggg tgatactgat tcgtgatttg 1181641 tgctatggtt tgcaaggctt gtagcaaaag caggagcaac agtaacgagt aaagcaaggg 1181701 ataatgcaaa accagttaaa gctttttcaa tttcatttta agcacttctt tttttaaaat 1181761 acaactttat tattaaatgg aatacaaaaa catccaaggt gtttttttgt tagtaagttg 1181821 agttaggggg attggatggc acttagaata ttgtttctgc tgatgggatg ttgattctgg 1181881 atatatttcc aacacgatta caggccggac atgaaagcga accttgcttt gatcggggca 1181941 atcatttcat ttacggctgc ggtttacttt aaagatattg atgtattgag agaagaggga 1182001 aaacaaatga acggaatttc tgagcgttgg aacacgttta aattacaaaa atcccctgaa 1182061 ccactctaga tcaggggatt gctttcccaa cagcttatta agtagcggaa ggcatgatca 1182121 acgatttagt atcaatttat taattgcgaa tactagaaac ataccgtttt ccgccttcct 1182181 tagaagtaac atattctcga ggaacattaa gtctattggt agaatgataa cttacataaa 1182241 gtttcatatt tgctcggctc gttacgatag ccgtatgatc catccaacca tcagcatagc 1182301 gaagacctat tttattatgg taatcatagt gatatacatc tccaagcttt acatttgaat 1182361 atgtatcaga aacagtcttc atttttattc cgccagcttt taaaatgtat gatctaaagg 1182421 ctcctgcatt aacccaagca tctgtatagg gtttccattc tttaaagtac ggcattcttc 1182481 cagctcttaa tgcttgggaa acaaagttag tacaatcttt gtctttataa tatttatagt 1182541 ttttatttgg ttttaaggca tatttttctg catatttcat tgcagcgtaa ccactatatc 1182601 ctttaacaga tgttgcagtc acagttagtt gattagagtt agcagcattg aagttcatac 1182661 ttactggttt atcttcactt ttcacttctt ctttatcatc atttttcact tcttgcttat 1182721 atttttttaa aaattcatct aatttaacat ccgaagaata ttcttcatca ttttcatatt 1182781 gtagagttga agaagaatta tttaattgtg ttacatttag ttgcttagaa gaattactca 1182841 atggtattac atttagttga ttagaagaat ttttaacttg agagaaactt agattagaag 1182901 tatttgttga ttgagaactt tgtttattag aagttgtttt gggaatttca agtttaatat 1182961 tatcgcccag agatgttgtt actttttcaa caccaaaaac aaagtttcga gtaatataag 1183021 cttcaacaat tagcttattg tttttttcag aagtcttaac atcgtctata tcgtatgtaa 1183081 actcgtggaa tttttgtttg tccactttac ttaacgcaga atacagtaag actccttcgt 1183141 cggaatcagt caatttagac tctttaggat gcgctaaagg agtgttgtgt tcaaaatcat 1183201 atttttgttg ttctaacata tccttaactt tttcgtaacc aatctcgttg gtaattgaaa 1183261 cattttcttt agtctcttta ttagtagtgg ctgcaaaaac ttcatttgtt gacactaatg 1183321 gtgacaatga tagacataaa actagtgaag caagtaattc ttttttcata cgaaacctcc 1183381 aataaaatct aaatataagt aatatttatc atttacacca attgaaatat ggcataaaat 1183441 acatgtaata atataacata aaaataaata cataaaaagg tatcggagga aaaaatgaaa 1183501 aagaaaacta aaattatact ttctctcttg gcagcactta ttgttatatt gatagtactt 1183561 ccagttctat ctcctgttgt ctttacagct tcttcggaaa aaggagcaat cagacacgaa 1183621 atttataaaa gaggatatcc ctaccaaagc tactttgcag ttctccagaa aagagaagga 1183681 gacaatgaat ctgggaatct ttattatgta aattggctag attggaaaga tgaaacaggg 1183741 caaactcctc acttatgcta ttcgaaaaaa tcatcagatg gtgaatacga agtaagttgt 1183801 ggcacagggc cgtaaaaata aattttaaaa ttgaataagt ccaagacgga aagcctgcgg 1183861 acactgatcg ttttacagag aaatttgtgc ttcgatcggt gtccgttttt tttcgcaact 1183921 aaccagatgt ctatcgcgat tactagctat gaaaggagta attagacatg aaacagtcca 1183981 aaaagaaacc atcacagaag caacatgagc gcttagatcg tttctggcaa caaatgatga 1184041 acactaacat gcaaacactc agacgtggca aaggcggcgc ttataaacgc agaaagtaaa 1184101 aagggagttt gaggatgatg aaaaacggat tcgcttataa aaacggaaag cttgtgaata 1184161 tcttttgcgg caaagaagag ctctataacg agttgaaagc cttcttggtc aaaaccttca 1184221 gtatcaacgt gaaagaggta tcgaggccct caatatatcg cagaacaaaa agcaaacaac 1184281 tggaatgaca cttactctat ttaactatca ggagggaaag cactatgaca gatcaaatga 1184341 ttgcatggga gattgaggaa tggattcgtg attataaatt catgctgcgg gagatcaaaa 1184401 ggctcaaccg tgtattaaac aaagtggatt ttattagcac aaagctcact gcaacatacg 1184461 gggaggaagc gggcatgcca aggggatcag caggcgtcag tcaggcagaa ttgcggcaga 1184521 tggaccgaag agaaaggcgg cttcacaaat atgaatctat tgtgcattac ctggacaatg 1184581 caatggaaca cattgaagaa gaaaagcacc gaatcgttta cgattgcatg atggaaggca 1184641 tgagctacac tgctattgca aaccaccttg attgctcccg ggataccatc agaaagatca 1184701 aaacagccat aatcggcaac atcgtcaata aagtcaaaga agccaacttt ctgcaatatt 1184761 tgaattcgtt taaatcggcg gtgtaaaatg gggggcagga tcggcgcggc ggattattcc 1184821 tgcgtcacca ccaatttcat acaatgagta aaacctccca gtggtaagcg aggatcaact 1184881 caactgggag gtcttacata gtgaatcggt gataaaacag cagcagtatt gcgtacatgt 1184941 taatatcccc gacaaaatat gtttttttca acagattcgt tcgacaaatt ttgcaaattg 1185001 ttaatcgata acttttcatt cccgatatta aaaatgggag tgaattgtaa aatgaaaaaa 1185061 cagaaaaata ataaaaagaa gaatattgaa aagcgaaata ttgaaaagcg aaatattgaa 1185121 gagaagaata atgaggactt agaagaactg gaaaatgcga tttatactta tcacaaaaag 1185181 gagctacttg ctttctttct tgaaaaaact cgaattggtc atgataagga agaatacaaa 1185241 aggttccaat ctcttcttta taagttggat attgaatgtt tagaatttgc tatatcgaga 1185301 ttttctcata tagatattat ccatgatcat tcaaaatatg ttccagcctt tatcccttta 1185361 tttgcagcat atctcaccat gttctttaat ttttatgaaa aacattgggg agctttatct 1185421 tttgctgctg gtacaattgc tgctattgtt tggataattg cagtagaaag aaaacataga 1185481 aatcaagcaa tttctattat gaaaatattt gaacaagtca aagagagaaa agtgaaagac 1185541 agatctaaag actgaaagga gaaaatatga ataaggataa attaaggtat gcaatcttaa 1185601 aagaaatttt tgaaggtaat acccctttgt cagaaaacga tattggagtt actgaagatc 1185661 aatttgatga tgctgtgaac tttttaaaac gcgaagggta tatcattggg gtccattatt 1185721 cagatgatag acctcattta tacaaattag gacctgaact gacagagaaa ggtgaaaact 1185781 acttgaaaga gaatggaaca tggtctaagg cctataagac cattaaagag attaaagatt 1185841 ggattaaata ataagagcat cctgcggggt gctttttttg ttccctgtaa actgcttccg 1185901 gtaagtctca ggatagacaa ttggcggtta acggcttgag cacggtggtg gtttagaggg 1185961 aatatctttt ccaaaacaac acgaatcaga agggggcggc ggtgaatgta gatggccgaa 1186021 aagcacattc aggcgtataa ggattacgtc aaaggcatga aatacaagga ccttgccgag 1186081 aaatacgggg tgtcagtgaa caccattaaa tcgtggaagc agcggcatgg ttgggaaagg 1186141 aaaaagggtg cacccattga aaaaagtgtg cacacaaaaa aaggcgggca accgggcaac 1186201 aaaaatgcat tagggaacaa tggcggcgca ccacagaaga atcaaaatgc tgtgactcac 1186261 ggctttttct ctaaattctt gccagaagag acgcttgaaa tcatggaaga gattcaggag 1186321 cgttcgccag ctgatatgat atgggatcag atacagattc aatatgcggc cattcttcgg 1186381 gcgcaaaaga tcatgttcgt ttctgataag gaagaaatga tcaaagagct gaaaaagaaa 1186441 aggtccctca tatctgaggt cagcgaaatt gaagatgggc ttgtcattag ttttagtacg 1186501 tggtttcgct acagacttta cagtgaaaca aacacctaac acatttcaca ttgcttcaga 1186561 ttgccttcaa acttgataat ataacttcta aaccttccta taaaatgaag gttttttatt 1186621 tgatttcaat ttttaaatcc tttacataca gcgattgatt aactcgagca atcaatgtcg 1186681 cagttatatt tatttttcaa gaaaatgtta taatgaaaag ccataaaatg atgggagggg 1186741 gaatttcgat gcattacata acggcatgtt taaaaatcat cagtgataaa gaccttaatg 1186801 agataatgaa ggaattcaaa aaacttgagg aagaaacgaa caaagaagag ggttgtatta 1186861 cattccatgc ttatccgctt gagccatcag aacgtaaaat aatgctttgg gagatttggg 1186921 aaaacgaaga agctgtgaaa atccatttca caaaaaaaca cacaatagac gttcaaaaac 1186981 aagaattaac ggaagtagaa tggttaatga aaagcaatgt gaatgattga aaggctcttt 1187041 aaaaagagac attcaatgac ttagtatcag ccacttgtga ctaagtagta aattgttgtc 1187101 caactcttat tttttctatt taatattttt tgagacgaaa atgttttttt aagctgattt 1187161 taaaatgtat tcaaagtcag ctctgtttga tttaatggat tatattattt ggatagcttg 1187221 ttaccatcat aatggagata ctccttataa attggaggtt aaaataatga gtcattctca 1187281 agaaaaaatt gcactaatta caggagcaag cagtcaaggg gatattggta cggctatttg 1187341 tcgtaagtta gcctcacagg gtatacatat cttctttact cactggaatt ctgatacggc 1187401 ctggatagaa gaatttcaac aagaaatttt acgtatgggt gtccgctgtg aggcaatgaa 1187461 aattgattta tcagatgcac atgctgcatt cacaatacat gaaaaaattt cagataaatt 1187521 aggatatcct tccatcctta ttaataatgc agctcattcc gcaagtgata attatgtatc 1187581 gttagatgct aaatcacttg atgagcatta tgcggttaat atgagatcga attttcttct 1187641 ttgtgttgaa ttcgcccgtc ggtttaaaaa atctaattta atatcaggaa gaatcatcaa 1187701 tatgacatca gggcaggatt taggtccttt gcctggggag ttagcgtatg cagcaactaa 1187761 aggagctatt tctgcattta ctaggtcgtt atcacaagaa cttgcaccat tgggcatcac 1187821 tgttaacgcc gtaaacccag gtccaacaga ttctacatgg atgacagatg aaataagaaa 1187881 ttttctttca cctaaatttc caatggggcg tattggcaca ccagatgatg cagcacgaat 1187941 gattgccttt cttgcaagtg atgaggctga atggataact ggacaaatta ttcattcaga 1188001 aggtggattt attcggggct aagctaatga aacacggtat acaccaatgt atgatgtatt 1188061 cccaaaacta aatctaaact tgaagcgaaa ataaggtccc ttctcttttt agagggggac 1188121 cttattttat tcatgcatgt tttgcatcca gaaaatctgg cggataaaga ttaataaacc 1188181 gttacatata cttttccgaa tactgcagta cctttaaaca aagtaatcgt ggctttccct 1188241 tttgatttag ccgtcactaa accattttga tcgacttcag caactttttg gttatcagtc 1188301 caataacgag tagctgaatt atttttaaca gaataggttt ctccaacttt tagaggtaaa 1188361 ttatagtctt gaatcttgat aacatgtgta ggtgaaatag aaatgttctt tacttcagta 1188421 ggtgtggagt ttatttcatg agctgaagct accccgctga ccgacagagc taacgcagaa 1188481 atcgataaag cagaaacaac cgtttttttg aaattcattt tgaaacactc ctttaaagtt 1188541 ttttgtcttg cactataaca attcaataaa agtaattatt ttccttgtaa ataaatgtta 1188601 ataatatgtg aacgatcaat tgatttgagc taagaatatt gtgtgccctg cacagagttt 1188661 gtatttatga tggaaaattg ctgagagaga atggccatcc ttaaaatgtt aatagcacac 1188721 atttgatggg tattagtttg ttgagcgtgt ggaaattttg ttacctgcac tttatccccg 1188781 aagataccaa atcacttttc ttcatcatgt tcttactttc gtactcatac attagaaaat 1188841 cttcgttcta aataggtgaa gaattggagt atttttatga atttctgctg aatatacatt 1188901 acatagcaaa ctcaaagagt ataaaaatcg cttttttccg gaagcttcgg taaaaaacga 1188961 aacttttgtc tctatgattt tgttttataa tgtaaacggt ttcttatata gtatacttat 1189021 actatcaatt tgctcaagta gatactgaca ggaaggatag aaaaacagat ggaatacata 1189081 aatacaagac aaaaagagat tttgtatctg ttgttatctg aacctgatga ctatttagtt 1189141 gtgcaagatt tcgcagatag ggtacagtgt tctgaaaaaa caatccggaa tgatttgaaa 1189201 gtgatcgagg attatctcaa tgagcattct catgcacagc ttattcgaaa accagggttg 1189261 ggcgtttatt tacatataga agaacaggaa aggacctggc taagccaaca attacatact 1189321 gaacattttt cttctaggca gcggagcgat aaggaaagaa tgctgcacat tgcttatgac 1189381 ttattaatga atccgaagcc tgtttccgca aaagacattg ccgctcggca ttttgtcaat 1189441 cgatcttcca ttaaaaagga tttatacgca gtagaagagt ggctgaagcg ttttgatctc 1189501 acactggttt ctaggcagcg gcttggatta aaggttgaag ggaacgaaag aaataaaaga 1189561 aaggcattgg caagaatatc tgatttgatt cacaatacag cgtttaccag ccaatttatt 1189621 aaaagtaagt ttttacatta tgaagtagac tttgtgacga aagaaatcaa atcactacaa 1189681 aaaaagcatt ccctctattt cacagacgaa acgtttgaaa gtttgttgct gcatacattg 1189741 ttaatggtcc gccgcatcaa aatgaagcag ccgatttcat tgtccccaaa agaaatggcg 1189801 gcagtaaaaa agaagaaaga atatcaatgg acatttgctt gtttacagcg gcttgaaccg 1189861 gtttttgcaa ttcgcttccc tgaagaagaa gccgtgtact taacattaca tatattgggc 1189921 ggtaaggttc gttatccatt gcagacagaa gagaaccttg aaaatgctgt gcttcctaag 1189981 gttgtagggc atttaatcaa tcgtgtttca gagctgaaaa tgatggattt tcacaaggat 1190041 caggatttga tcaatggttt gaacattcat ctcaatactg tgctacaacg gctgagctac 1190101 gatctttctg tagcaaatcc tatgctcaat gacatcaaaa agatgtaccc ttatttgttc 1190161 cacctcatca ttgatgtttt ggaagacatc aatcaaactt ttgatcttca tattcctgag 1190221 gaagaggcag catatttgac attgcatttt caggcagcga tcgaacggat gcagggcagc 1190281 agcgagacac ataaaaaggc ggttatcgtc tgccacatgg ggattgggat gtcacaattg 1190341 ctgcggacaa aaattgaacg gaaatatcac caaatcgctg taatggcttg tattgcaaag 1190401 gccgatttaa aggattatat caaaaagcat gaggatattg atcttgtcat atccaccatt 1190461 gcgctggaga atataacggt tccccatatt gttgtgtctc cgcttttaga gcctggcgaa 1190521 gagaagaaat taagtgcgtt tatacgtcag ctgggcgaat cacaccgcca aaaacaaaaa 1190581 acgtttcaga tgctgaacaa tacgactcct tttttggttt ttttgcagca ggaggcggag 1190641 catcgctaca agttaatcga acagctggcg acagctttgt ttgagaaagg ctatgttgat 1190701 aaggactatg cggttcatgc ggtgatgagg gaaaaaatgt cggctacaaa tattgggtca 1190761 ggcattgcca ttcctcatgc aaacgctaaa tttattaaac aatcagcaat cgcgattgcc 1190821 acattaaagg agccgcttga atggggaaat gaaaaagttt cgctcgtttt tatgctggct 1190881 gtcaaacacg aggatcaaac tatgacaaag cagctgttta gcgagctttc atatcttagc 1190941 gagcagccgg ccttcgtcca gaagctgacg aaagaaacca atgtcatgac atttttatct 1191001 catttggatt attaaaagca gggattattc cttgcttttt ttgttcatgg cagggcttga 1191061 gaaataaatt tgcgagtgaa gacgcctatt ctccagcaat gatctaaata aaataagagt 1191121 ttaatagttg gagaagaaat gttacactct tttctgtata tggtaaagaa tgaaaaaaca 1191181 cgattcggtt ggtagtccgg atgcatgatt gagaatgtca gtaaccttcc cctcctcggg 1191241 atgtccatca ttctttaata tcttttatga ggagggaatc gttatgaaat taacgattta 1191301 ctacgatggt cagttttggg taggcgttgt tgaagttgtg gacaatggaa agctaagagc 1191361 ctttcgtcat ctttttggca aagagccgag ggattctgaa gtattagagt ttgttcataa 1191421 ccaacttttg aatatgatgg cccaagctga gcaggaagga gtgcgtttac aaggcaggcg 1191481 tcaaaaaaag atcaatccaa aaagattgca gcgccaggtt tcaaaagagt tgaaaaacgc 1191541 cggagtaact tctaaagctc aagaggcgat aaagctagag cttgaagcaa gaaagcaaaa 1191601 gaaaaaacaa ataatgaaag aacaacgaga acatgtaaaa gagcaaaggt atatgctcaa 1191661 aaagcaaaaa gcgaaaaaga agcacagagg taaataatcc aaacaaaagc aggcgcagtg 1191721 cctgcttttg taattaagga ctctactttg taacatatat ccaatgttta tactccgctg 1191781 atttatgatt caatataaac cctaacttct ccaaggtttt ttgtgagcct agattatcat 1191841 gttcgcatct tgcggtgatc cgggatactg tttctcggct taatgcccag tttattagtt 1191901 tttgggcggc ttccacacaa taacctttgc ggcgatgact tttatttgtt gcaaaaccga 1191961 tttcaatcat gccattttcg tctgggtcac ctaaaaatcc agttccccca acaatttcat 1192021 aattgtcctt ctttacaata atccatgaat caaatccttt tgttccattg tttttgacta 1192081 aaatctcgcg gaaataaggt atcgcttcaa aaaaatcaga atttggccat tcaccatttg 1192141 tttcatagcc taattctttg atagcctgat gatcttgttt agacgcggcg tcaagaaggg 1192201 gaatatcaat cgtttgtaat cgtaatcgat tcgtttcaag gagaaccata tatttaatcc 1192261 tcttttcttt ttactgggaa taatgataac atataacaat tttctctggt accttggcag 1192321 tagagaaaga tgaaaaaatt gagggggatt gaaagagtga caggtgagag tttgcccaga 1192381 ccaaaaacgg gtaggaaaat gctgatgtta atgtgtccct acccgttttt ctgttcctga 1192441 atgcagggtt tctgataaca tgttgtgcta ccttttcgca atcaaataaa gcgatatggc 1192501 tctttgggtt tgcacaggat tatgaatgat aatgacccat tggtttcttc gtcttggaaa 1192561 gcttgctacc gcatacaatg gagcagtatc gcgcggagtg aacccaccat ttatcacgtt 1192621 gatatctctt ccttcaagat gacaaactaa gtattcacct ggattgatga cctgttggtt 1192681 cgtccatgcg taagaataaa agccgtctcc aagatcttcg gtggaagatg gggggacaaa 1192741 gccatctaca gtcaatgtga tttctcttct tcgctgtctt tctgaaaagt ctggacttct 1192801 ttgagggtta tgagtatgtg aaaagtaagg aattaacgca gggccataaa agtaatgata 1192861 caaagcaacc actcctttat tttccattca tacaaattgt atgtgggagt tatttgttca 1192921 ttcctgtttt gttccatgta gactaataat gggctatagg cgtccaagga aatcaatttg 1192981 tccttccgtt gattcaatgc tagtaacctt gaaaatgcag gttaggatga tagaatttac 1193041 atattactgc aagaagttag acatacatca ttttgatagt gggtgaaaac aatggcgaaa 1193101 aaaatggcaa aaacaaatgc ggttcgtctg atagaacagc agaacatctc ttatgaggta 1193161 ttagggtata aaacagacgg ccagccggta gatggcatct ctgttgcgga aaaaatcggt 1193221 tattctttga aatatgtata taaaacgttg gttgcagcag caggaacaaa tcattattat 1193281 gtctttgttg tacccgttgc agaagagtta gatgtaaaaa aggcagcaaa ggtgacaggg 1193341 gaaaagaaaa tagaaatgat tgcaatgaag gagctgttag cggtaactgg ctatcttcgc 1193401 ggcggctgct cgccaattgg catgaaaaaa ttgttcccga cctatattga tgcatctgca 1193461 gaaacgcttg attttattat tgtcagtgca gggaaaatcg gtatgcagct aaagttggcg 1193521 ccacaagatt tagccagatc atgtgatgcc gcatttgcag aaattgtata gatgcagata 1193581 taggggaacg aaaaagctta gtcatatcga ttaagctttt tccgcatccc tttcaaatat 1193641 gatttcaaaa taagcagctg ccccataccc atctatactg ggagcgaaaa tctgaacgaa 1193701 tctccagcct cttttcgcat aatcatggat gatttgctgg tagtcttctt taggccttct 1193761 tctcatcgta ctcagctcaa ctcttacgaa ttcatattct ttcatcgttt gatccctcct 1193821 attaaggtat acgtaaaatg gagcgagaag ttccgaaaac ctaggttaag gtcggaaagt 1193881 atatttcact cactaaacaa atccatttat gcctgatgcc tgcatgcatc tgggaagagt 1193941 taaggggcta taaaaacgaa ttttaccggg tcagcagtcc aaatgaatct cttgcttatt 1194001 gcatttgact gagtatataa gtaaaaaaag agcggccaga acatataaga aggagatgat 1194061 cattaacgca ctcataacag ggtagtgttt agcggagtag atgaaaaaat caagctgtga 1194121 aatttgtttg gggctgctga cggcatcaat tccattaagc agttttgaga gtttagcagt 1194181 atagttccaa tcaaatcgat ctgaaacaag ctcgcttcct tgataccaat taacagcagc 1194241 taaaaacaga aataccataa tagaaaatcc aagctgaaca actaaaaata ttcccttcac 1194301 ttttgtatga cctccaaatc tatgaatatg ggaaaatcaa acaatatatt accaccgtat 1194361 gggttattct tgcaatttca cttccataca actcaaacgc aagtctattt ttttgtttgt 1194421 ttttggctta taatacctga tgatggaaaa agagtgcggg tttatagatt agagaaacaa 1194481 atgtatttct tagcattttt tatttgtgga gagagtatag aagcattcga ttagatctgc 1194541 tttttcacag aaacggtttt catctgtttg cctgagcttt acaattggct ggcaaaaaaa 1194601 caatgatttc tttcaatcaa aacatgcaac gatgcgacac attttatatc ttgatgactt 1194661 atttcattgc ctttaagtca tcctatcgag aaagcgatgg tattttatga acaaagaaac 1194721 cctaaaaaac atactcatga ttttttcaat atgcgcaaca ctccgagaaa ccgatggtat 1194781 gcgcatagct gatagctgga ttttgagtga gattatacga tttttgattt gcatggttgt 1194841 gttttttgcc atgacatttc tattagatgc tgtttttcca aacaaaaaag agtcacatta 1194901 atgtgtggct ctttttgcat catctgatca gaaacatcat aaatgaatcg atcatcatga 1194961 tgaagaacag caagcaaaaa taaataagcg agtagacaaa catatccttt gcccacttca 1195021 cgtcatcgtc tgttttgaat cctttgatgc tttttttgat ccatatgcct ccgagaacca 1195081 aggcggctaa gaaataaaat gggcttatat ggccggtgcc gagagagaaa ggaaataata 1195141 gcgtgaccgg caccaggacg gcaatatatt gcatcatttt tatttttgtt acatgattgc 1195201 ctttgactac tggcaagagc ggaacgccag cagcgcgata ttcctctttg cgtcttatcc 1195261 caatcgccca aaaatgcggc ggctgccaca gaaacataat cgtgtacaac agcactgctg 1195321 tcatactgaa gtcaccggtt acggcacaat accccatcaa tggcggcgca gctcctggga 1195381 agctcccgac aaatgtgctc cacacagacg ttcgtttcac ccataccgta tagatgatcg 1195441 cataaaaaat aaaggcggcc agtccgagaa aggccgttaa tggattgagg gaataaagca 1195501 tggcaagacc tgcgattcct aaaacagagc catatgttaa gatcatggct ggcggcattt 1195561 tccctgtgac cgaggccctg ctgcgagttc gtgccatttt tgcgtccata tgccgatcaa 1195621 aatagttgtt atagacagtg ccggaagcca tcacaaacgc ggttcccaac attgctgtta 1195681 ccattgtcat caaaaaagcc aagccggtta acgttttttc tgcgcttgca aacgcgatcc 1195741 aaaacccgcc gaaggctgct atcgagtttg atatgataat gcccggcttt gcaagtttga 1195801 taaaatcgta aatggttacc cggttcgaag cttttatgta ttttgtttca gatatggctg 1195861 cagaatctct tgtattctcc aaaaatagac gcctccccca aaactgcatg cttttgttat 1195921 cgtaacaaga gggggacaga atcacaatta tttcccatat ttgtcatgat attgtcattt 1195981 ttaaaacaaa aaaatgggga gctggactgc ccccattttg atatgtggcg actagtaacc 1196041 gtaacctccc ccatatcctc cgccataacc tccgccgtaa ccgtaccaag ggtagtaagg 1196101 cggtcgcggg cgcgggtagt aataaggcgg gcgcggataa aacgggtaga acggataata 1196161 cggtcttgga taataataag gcggataaaa tggcggtctc ggacgcggat aataataagg 1196221 ctgtctttca tcataagggg taatttgttc aaatgactgt tcattcaaag ggtaatccaa 1196281 gaggaaaacc tccctagctt tttttattcc ttttaccata ttcctgatgc ttaagttggg 1196341 tgtatgtaca ttcatgaaat tcggtttttt ttatgatgaa attccttaaa aaggattgac 1196401 atgaacttct aaatctcata gtattacaaa tgtgaaataa atgttactac aatgttacaa 1196461 aaacatttct aaatagatac agttccaact gatgaagagt aaatcgaaat ggctacgaaa 1196521 gaaggagttt ttgttgttgg caaaaagaat caaatggttt catgtattaa tagcagttgt 1196581 atgtgtggtg ggccttatcg gctttttcca taatcattca ttgaaaaaag aaacggtcat 1196641 gaataaagta agaactgatt ctcaatatgg gaatgttgag atcgcaacgc ttgtgaatga 1196701 cgggaaaact tttaattacg cggtaaacta tcctgttttc aaaaatgaaa aaatggattc 1196761 ggcattaaaa agattcgcag aaaaagaggt tcgtcaattt caaaaggaaa caaaggacgt 1196821 tgaccaagag catacgacaa aacgcaacga attaaatgtt gattataaaa ttgtccatta 1196881 tgccaaacag acagtggcga ttgtatttaa tgaatataaa tacatcggcg gggcacacgg 1196941 gcaaaccgtg aaaaaaacgt ttaactatga ttttagtaaa caagcgtttc tttccattga 1197001 tgatattttc aaagaggacg ctgactactt acataagctt tcgttaatcg cttatcacga 1197061 gctgaaaaag aataaggaca ttgccgcgga cgatgcactg ttaaaggaag ggacggctcc 1197121 gaaaaaagaa aatttcagcc gctttgccat caaggaggat tatatcgaac tttactttga 1197181 cacatatcag gttgcagcag gctatcttgg agagcaatcg attgccatta agaaaagtct 1197241 tttgaaagac attctgaaag aacaatatat tgataaagca aaaaataaaa ataaaatcaa 1197301 agaacaaaag ccgaagcatg aagtgatttc tttacccaaa gaggaaacag ttgatccaaa 1197361 tcaaaaagtc attgcgctta ctttcgacga cggcccgaat cctgcgacaa caaatcagat 1197421 tctagactcc ttgaagaaat ataagggtca tgccacgttt tttgttttgg ggagcagagt 1197481 tcaatattat ccggaaacgc taataagaat gctgaaagaa ggaaatgagg ttgggaacca 1197541 ttcatggagc catccgcttc tcacaaggct ttcagtgaaa gaagcgttaa agcagatcaa 1197601 tgatacgcaa gacatcattg aaaaaataag cggatatcgt ccgacgcttg taagaccccc 1197661 atacggcggc attaatgatg aactgcggag tcaaatgaaa atggatgttg cgttatggga 1197721 tgttgacccg gaagattgga aagaccgtaa caaaaaaaca attgttgacc gtgtcatgaa 1197781 tcaggcggga gatggaagaa ccattttgat tcacgatatt taccgcacct ctgctgatgc 1197841 ggccgatgaa attataaaaa agctcaccga tcaaggctat caattggtga cagtttctca 1197901 gcttgaagag gttaaaaaac aaagagaagc gaaataaatt agaaaaggct gtccgtacgg 1197961 acagcctttt ttctatttaa taagagcctg tggtggccca aacatttaag tttggtcctg 1198021 aatacttgcc gaaagcgtaa gaagtccttg gatctaaatc atataccatc ggtgtatagc 1198081 aagacttttg gccggccacc gcttttccat tgccgcctgc agaatcacaa ttatatcttt 1198141 ttccgtctgt gttccgggta atctccgcat ttgcttcata gccagacgtc aatgtattat 1198201 tcatcgtgat ttttgcccaa gccgttttac atgtactgct gaatttaagc tcgactactc 1198261 cgatgacttg attgctggca ttcactaagt ttgaggattt ttttgtagag ccgctggacg 1198321 cacaatcatt gtaataaggg ctttttccat cgtaggcatg ggtttccgcc ttggcgggtg 1198381 cacctttgac ggcaaaaaca aatactactg cgaataacac caatgaagcc ttcataaaca 1198441 gtcttttcaa tttatgacct ccttaatatg gcaaacaata aatcatatgg aggaacaatc 1198501 aaaacatgca tgcttttttg tgaacaataa aggcggccgg gaggatggag ttcttggccg 1198561 cctctggtat gaggttatgc ttttacatca atggtttgtc cgagagttgg atgttgaatc 1198621 atctttaagg tttgatcggc attttgctgg gcggtgtcca gccttttttt cgttaaagca 1198681 atatttacat tctgggcaag ggatgcttga tgcatcgcaa ccgataaagc aggaatatcc 1198741 atggttccac ctcctatgcc ttacctatcg gcgggtttgt atgattttac agtgaaaaat 1198801 ggcttaattt ctcttgttga cccttacgct gcggcatatc gtatgttttt gacaaggagg 1198861 gaatcaggat gaatctagta atggaaaaga cctttgagca atacgaaaag ctgttttcaa 1198921 tggaagaaca gaaaagagaa gatgtatttc ggtatacgat gatgaggccg tttgaaaaga 1198981 tgtggaccgc catccaagtt ccgctgaaag cgaaggagcc aaacggctat gatgtgatca 1199041 tggctgcgaa aatgctgggc tatttggatg tccgtgatgc tgaaagcggc cagaaagcac 1199101 tacaaatact gaaagaatca catgtttcag agacagctga atctgcactt cggcaatgca 1199161 tattttttgc tgagcgcgaa cagctgcggg tgaatgcaaa ggagatcaaa ttcggccttt 1199221 atatcgctga tccaaataag cttcagctgc aaaaaggcta ctgcgggttt ggcgggatac 1199281 cgggctttat tcatgtatgg attaatccga acagttataa cctgccaagg attccttcca 1199341 ttattgctca tgagtttcat cataatgtgc ggttttcgta tatagatttt catcatggct 1199401 ctgtaagtgt cggggattat cttgtgattg aaggattggc ggaatcattc gccagagagc 1199461 tgtttggtac ggaacgattg ggcccttggg taactcgttt tgatcatgaa gacttgcaat 1199521 attccattga tgtgattaat gaggtgctgg atgtgaaagg attttcggaa gtcagccgtt 1199581 atatgtttgg tgatccaatt gctaacgacc aaggctttaa gcctgcaggt ttatcggctt 1199641 ttgcgggtta tgcagttggc tatcatgccg ttcagtcatt tatgaatcaa catcatatca 1199701 cgataagcga ggccacacgt ttggatgcga agaccattat ttctcaatgc ggtctgtttt 1199761 ctacatgaaa aaagcgtcac atacagcggc gctttttgat tcccaaaacc agcagttcta 1199821 tggcggcaca ggcggcaatt ccgattgtat atgcttcgat atcgctccat aaaaaaccgt 1199881 accctagtac aagcccgcca agagaagtat ctctaatctg gtcgatccat tcggcatgat 1199941 agagctggct gaattcaatg acaaaacaga aagaaagact gataatgccc gttatcattg 1200001 tcttcagctt ccgaaataga aatccgcatc ccgtgaagat catggcggcc cacaacgagt 1200061 ctcccagata agtattgagg gtatcaggaa gaacactgga gaatgctctg gatccaagcc 1200121 ccagcccaat gatcagtatg gtgaaaactg catatatcca acgatttcgc ttcattgcga 1200181 attgataccc cgtctctgct tcatctccct gtattgtaag gaatatagct tttatttgtc 1200241 cactaaaaaa gcggctgaat agccgcgtag ggtgtttatt ttgcttttag gtttacatgg 1200301 tcggctgtct gatccgtgcc tattacaaaa tggagttcat agcggcctgt atcatataca 1200361 taatcgattt catcggtaaa cgggacggtt aacacccgat ttactggtcc taattgcttc 1200421 tgcagcactt ccggcgtaac tccgcctaaa ttcagctgcc gttccacacc ggttccaaag 1200481 tagcggattt ctgaaattgt catgtcttta tgataggaaa atccgtagcc cggctgtccc 1200541 atattccagt gatataaatc aaatcgattg tctcccccga ctggtctttc cggttcccca 1200601 aacgcagcgt ggacatcccc ttttgtgctt ttgttaatgg taaggccttg cgcctgctga 1200661 ggcatttccc ctttataggc ggtgttatag aggtttttga caagctcagc ggctgattga 1200721 ttcgtgtttt ctgagagtgt gtttgtttga gctgcggcct ttgccggtgc tgaaaaggac 1200781 gcagccccaa agccggtaaa acagcttgtt actgctgctg ccgcggttat agcagacatt 1200841 gtctttttca tgttaatccc tcctaattga tctaccattc cgtttccccg tgtttttgca 1200901 acgaaacatg tgagtgcgct ttgtatgttt tattgagttg ttgtaaggga actgaaatag 1200961 gtaattcggt atataaagca agaaagggga atggagatgg ctggcaagaa aacaatcaca 1201021 ataaacggcg ttgaaatgga agcgtccgag gaacagacgg tgctgcagct tttgaataac 1201081 agctcgattg aagtgccgca agtttgctat catccaagct tagggccgat tgagacatgt 1201141 gatacgtgca tcgtcagcat caatggtgag ctgaagaggt cgtgctccgc tgaattaaag 1201201 gatggggatg tcattgatac gctctcacct gacgtgaaaa aagcgcaggt catcgggatg 1201261 gacaagattt tatataatca tgagctttat tgtacagttt gcgattacaa caatggggga 1201321 tgcgaaatac ataatacggt gaaggaaatg aaaatcaatc accaaagcat tccgtttgat 1201381 cacaagccat accataagga tgaatcccat ccgttttatc ggtatgatcc agatcaatgt 1201441 atattgtgcg gacgctgtgt tgaggcatgc caagacgttc aggtaactga aacgctgacc 1201501 attgactggg agcggaaacg cccgcgcgtc atttgggata acgacgtgcc gatcaatgag 1201561 tcgtcatgtg tgtcatgcgg ccattgttca acggtctgtc cgtgcaacgc gatgatggaa 1201621 aaaggaatgg aaggggaagc cggatattta acaggcatca ataacgaaac gctgcgaccg 1201681 atgatcgaga tcacgaaagg cgtagagaca ggctacggct cgattctcgc gatttctgat 1201741 atggaatcgg ccatgcgtga tgaacgaatc aaaaaaacga aaaccgtctg cacgtattgc 1201801 ggcgtcggct gcagctttga tgtctggaca aagggcagag acattctgaa agtagagccg 1201861 caggaggaag cgcctgccaa cggcatttct acttgtgtga aaggcaagtt cggctgggat 1201921 ttcgttaaca gcgaagaacg cctgacaaag ccgctgatcc gtgaaggcga tcatttccgt 1201981 gaagcagagt gggaggaggc gttattgctg atcgccagca agttcactga attaaaagag 1202041 gcgtttggcc cggattctct cgcttttatt acatcttcta aatgtacaaa tgaagaatcc 1202101 tatcttatgc aaaagctggc cagaggggtc attggcacaa ataatgtgga caactgctct 1202161 cgctattgcc aatctcctgc gactgccggc ctgttccgga cagtcggcta tggcggtgat 1202221 tcaggatcaa ttacagatat cgcgcaagcg gaccttgttt tgattatcgg ttcgaacacg 1202281 tctgagtcgc atccagtctt atccactcgg attaaacggg ctcataagct gagagggcag 1202341 aaagtgatcg tcgcggatat cagaaagcac gaaatggcag agcgctcaga tttatttgtc 1202401 cagccgcgtg ccggatcgga tatcgtctgg ctgaatgcga tcgccaaata tttaatagaa 1202461 aacggcaagg ccgatgaacg atttttgaga gaaagagtga acggacggga tgaatatgta 1202521 aaaagcctcg cgccgtacac acttgaatat gctgaggaga aaaccgggat tgatcaagaa 1202581 acccttatcc aaatggcaga gatgatcggg caagctgaca gtgtgtgcgc attgtgggcg 1202641 atgggcgtga cacagcatat tggaggaagc gacacgagca cggcgatctc taatctgctg 1202701 cttgtgacag gaaactacgg aaaaccggga gcaggttctt acccattgcg cggccataac 1202761 aacgtgcagg gagcaagtga ctttgggagt atgcctgaca gactaccggg ctatgaaaaa 1202821 gtgacggacg aacaagtccg ccaaaaatac gagcgtgtgt ggggtgtgcc gctgccgaag 1202881 gagccgggta tgaccaacca cgaaatgatt gaaaaaatcc attccggaca gttgaaagcg 1202941 atgtatgtaa aaggtgaaga aatgggcctt gtcgactcca atatcaatca tgtacacgct 1203001 gcatatgaaa agcttgattt ctttgtggtg caggacattt tcctttcacg tacagcggag 1203061 tttgctgatg tggttcttcc tgcgagcccg agccttgaaa aagaaggaac gtttacaaac 1203121 acagaacgcc ggattcagcg tttgtatcag gtatttgaac cgctgggtga atcaaagccg 1203181 gattggcaga ttattatgga ggttgccaat aagcttggcg ccggctggct ctatgagcat 1203241 cctgcagaca ttatggagga agcagccaag ctgtcgccga tttatgccgg tgtcacctat 1203301 gaacgtcttg agggctataa ttccctgcaa tggcctgtaa acgctgatgg aaaggattcg 1203361 cctttactct ttacagagcg cttccctttc ccagacggca aggccattct ctaccctgtc 1203421 cagtggacag agcctaagga attcggtgag gaatatgata tccatgtcaa caatgggcgg 1203481 ctcttggagc acttccacga agggaacctg acttacaaat caaaagggat ttcggagaaa 1203541 acaccggaag tgttcttaga aatttctcct gagcttgcgg cagaacgagg gattcaggac 1203601 ggaaccctcg tcagactcac atcgcctttc ggaaatgtca aagtgaagtg cctgattact 1203661 gatcgagtca aagggaagga agtatatctg ccaatgaacg attcagggga agcggcgatc 1203721 aacctgttaa caggcagcca tgccgataag gataccgata cgcctgctta caaagaaaca 1203781 tcggccaaga tggaaatttt gaagcacgac ggaatcagcc cgctgcctaa gatcaaccac 1203841 cgcaacggca atccgcagcc gcaaatcggt gtgcaggttc ataagaaatg ggcgcggaag 1203901 gattatattt tccctggtga cgctgtgaaa agggggatgg gccataatgg ctaaagcgat 1203961 taaacgaatc caaaaaatcg aggtaacaga agaggatcag cgaaagcgtg atttgcggga 1204021 aattgaagat gctctaattg accacaaaga agcgattctc gaaacattgc atatgctggg 1204081 ccatatgaac gagcgcgggg tcctgccgtt gctccgcggc ctttttggtc aaggggataa 1204141 agttcttgat atcctggtga aaaaggcaga tacagaggaa acagccaata cgctgaaaaa 1204201 tctgcttctt ctgtttggaa cactcggcat gctggacgtg aagcagctgg agcctctcat 1204261 tttgaaagtg aatgcgggtg tggcaagcgc tgtagagcag aaaaacagtg aagaaaagac 1204321 aggttatttt gatattatcc gctcgctaaa agacccggaa atcaacaaat caattacact 1204381 gctcttttcc tttttaaaag gaatgggaca agatacaaag gagctggaac gcacgacgca 1204441 gcctccggaa caccaaaaac atcatcagga accccgagag aaaagaggaa tgaataagcg 1204501 agattgacct cccacccgag cggcttcagc cagctcgggt tttttgatga aaaggtctaa 1204561 tggactagta aaaaatattc aaatactagg aagaagtaag attgtgatga atgagataga 1204621 aataatcgtt actttcttac ctgttaagaa aagggaaaat ctgattataa tagaaatcga 1204681 ttactttaga tgggggaaca atcatgaaaa aagtcttatt actattattt gtcttgacga 1204741 tcgggttagc gctttctgcg tgcagccaat cgagcgatgc gtcagagaag gaaaaaccga 1204801 aagagaaaaa atcgcaagaa gagcttgaaa aggaacttga taaggaattg aaaaaaggcg 1204861 gtgagccgaa gaccaaaaaa gatgatcaaa tacataaaat aggagaaaca tttaaagcag 1204921 gacatacgaa ttttacagtg aataaagttg atagagtgca aaaaggtgaa tatatgaatg 1204981 ttggcggagc tgtaaatgag gagacaaaaa caataaaaga tgatgaggaa cggcttatta 1205041 tagaagttac gatggaaaat ataggggaag attcaataag ctacaatttt atcgggtttg 1205101 atttaagaga taagaatgat caatcagtgc ggcctgtttt ttctatagaa gagaagggca 1205161 gaatccttat gggaggaaca ctagtatcgg ggaaaaaggt tacaggtgta ctcagttatg 1205221 tcatccctaa aggagaacag aaacattaca cactggtata taatccgttt ttagctgata 1205281 caaatagcag taatacagaa gagagagtaa aggacgatat tgattacttg gtgaagttag 1205341 attagatgct aatttacagt tgcacgtttt tcatctgtgg aaaacgtgca ttttttatag 1205401 cgaaacttga cttgaaagga tgagtgataa aagtgcaaac caaatggctg gaacgggcac 1205461 agcggattcg ggcgatcgcc caagcggggc ttgctttttc caaggatgtg tacgacaggg 1205521 agaggtacga agagctaatg aagcttagcg cggaaatgat ggcggattac tcggagaagg 1205581 acattgaagt tatcactgat ttatggcaag gcgagaaggg ctatccaaca ccgaaagcgg 1205641 atgttcgcgg cgctgtattc agagagaatc agattttgct tgtccgggag aagcatgatg 1205701 agctgtggtc gctgccgggc ggattttgcg agattggttt atcgccggct gaaaacgttg 1205761 tcaaggaaat caaagaagag tcggggtacg atacagagcc gtctcgattg ctggccgtgc 1205821 tagacagcca taaacactct catccccctc agccttatca ctattataaa atcttcatcg 1205881 catgcagcat gacggacggg cagggggaaa cagggatcga gacgaatcat gccgcttttt 1205941 ttccggaaga cagactcccg ccgctttctc ctaaacgaaa cacaccctca cagcttagca 1206001 tgctgtttga ctttttgcgc catccggaca agaaaacgat atttgactaa aaaagaaaga 1206061 gcctgtgggc tctttctttt ttataatgta atgtgttttt cgttggcgag tttcagaagg 1206121 gtcaaaatag aatcggcttg tttatggccg agtttttgct ttaatttgtt ttcttcaact 1206181 aatcggctgc cataaatttt gacggaggct ttgtcgacga cagtatgcca gttttcctgt 1206241 ttttttccct caacaagcgg tttttcatgt ctctcagaaa aagagaacac aaagagtacg 1206301 aatgcaagtg aaagtaggat tccgacaact tgttttttgt aatcagtctg tgctgccacg 1206361 ttgttctctc cttcaccttt taccttctat ttaatcatag aaccaaatta ttttacataa 1206421 tgggaaagtc atttttggag ttagtgcatt tggttgaaaa cagagacgtt ttttgagcgg 1206481 agcggtgcaa ttgaatccat attggatttg cgtgcttatg cctaaggtca cgttgtgagc 1206541 caaaacagca gtgcagaata gaaaaaaatt gaaagattat ggtaagatga acgaaattcg 1206601 agggggaata tatgatgcct gcatcgaaca tcgtgatcgc ctgcctgctg ttatcaattt 1206661 aattatttgt ggtagtccct ctctttttcg aaagcgggag gtgaagtgga acattaattg 1206721 ctgaattctt tcaaggggag tgaccgtaca tgaatgtgtt aaaccgccgg caagccttgc 1206781 agcgagcgct gctcaatggg aaaaacaaac aggatgcgta tcatccgttt ccatggtatg 1206841 aatcgatgag aaaggatgcg cctgtttcct ttgatgaaga aaaccaagtg tggagcgttt 1206901 ttctttatga tgatgtcaaa aaagttgttg gggataaaga gttgttttcc agttgcatgc 1206961 cgcagcagac aagctctatt ggaaattcca tcattaacat ggacccgccg aagcatacaa 1207021 aaatccgttc agtcgtgaac aaagccttta ctccgcgcgt gatgaagcaa tgggaaccga 1207081 gaattcaaga aatcacagat gaactgattc aaaaatttca ggggcgcagt gagtttgacc 1207141 ttgttcacga tttttcatac ccgcttccgg ttattgtgat atctgagctg ctgggagtgc 1207201 cttcagcgca tatggaacag tttaaagcat ggtctgatct tctggtcagt acaccgaagg 1207261 ataaaagtga agaagctgaa aaagcctttt tggaagaacg agataagtgt gaggaagaac 1207321 tggccgcgtt ttttgccggc atcatagaag aaaagcgaaa caaaccggaa caggatatta 1207381 tttctatttt agtggaagcg gaagaaacag gcgagaagct gtccggtgaa gagctgattc 1207441 cgttttgcac gctgctgctg gtggccggaa atgaaaccac tacaaacctg atttcaaatg 1207501 cgatgtacag catattagaa acgccaggcg tttacgagga actgcgcagc catcctgaac 1207561 tgatgcctca ggcagtggag gaagccttgc gtttcagagc gccggccccg gttttgaggc 1207621 gcattgccaa gcgggatacg gagatcgggg ggcacctgat taaagaaggt gatatggttt 1207681 tggcgtttgt ggcatcggca aatcgtgatg aagcaaagtt tgacagaccg cacatgtttg 1207741 atatccgccg ccatcccaat ccgcatattg cgtttggcca cggcatccat ttttgccttg 1207801 gggccccgct tgcccgtctt gaagcaaata tcgcgttaac gtctttgatt tctgcttttc 1207861 ctcatatgga gtgcgtcagt atcactccga ttgaaaacag tgtgatatac ggattaaaga 1207921 gcttccgtgt gaaaatgtaa tagataagga gactggagat tcatgaaaaa gtaccatatt 1207981 tcgatgatca atatcccggc gtacggacat gtcaatccta cgcttgcttt agtagagaag 1208041 ctttgtgaga aagggcaccg tgtcacgtac gcgacgactg aggagtttgc gcccgctgtt 1208101 cagcaagccg gtggagaagc attgatctat catacatcct tgaatattga tcctaagcaa 1208161 atcagggaga tgatggaaaa gaatgacgcg cccctcagcc ttttgaaaga atcactcagc 1208221 attctgccgc agcttgagga gttatataag gatgatcagc ctgatctgat catctatgac 1208281 tttgttgcgc tggctggtaa attgtttgct gaaaagctta atgttccggt cattaagctc 1208341 tgttcgtcat atgcccaaaa tgaatccttt cagttaggaa atgaagacat gctgaaaaaa 1208401 ataagagaag cagaggctga atttaaagcc tacttggagc aagagaagtt gccggctgtt 1208461 tcatttgaac agttagctgt gccggaagca ttaaatattg tctttatgcc gaagtctttt 1208521 cagattcagc atgagacgtt cgatgaccgt ttctgttttg tcggcccctc tctcggagaa 1208581 cggaaggaaa aagaaagcct gttgattgac aaggatgatc gcccgcttat gctgatttct 1208641 ttgggtacgg cgtttaacgc atggccggaa ttttacaaga tgtgcatcaa ggcatttcgg 1208701 gattcttcat ggcaagtgat catgtcggtt gggaaaacga ttgatccaga aagcttggag 1208761 gatattcctg ctaactttac cattcgccaa agtgtgccgc agcttgaggt gttagagaaa 1208821 gctgatttgt tcatctctca tggcgggatg aacagtacga tggaagcgat gaacgcaggt 1208881 gtgccgcttg tcgtcattcc gcaaatgtat gagcaggagc tcactgcaaa tcgggttgat 1208941 gaattaggcc ttggcgttta tttgccgaaa gaggaagtga ctgtttccag cctgcaggaa 1209001 gcggttcagg ctgtatccag tgatcaagag ctgctcagcc gcgtcaagaa tatgcaaaag 1209061 gatgtaaaag aagctggcgg agcggagcgt gcggcagctg agattgaagc gtttatgaaa 1209121 aaatccgctg tcccgcagta aaaacataaa aaccgaaatc aatttgattt cggttttctg 1209181 tttaaatatt ttttttcatc ccgcatctcc ggcattctct aagaaatttt ccgcctttta 1209241 cagagctttt gaacagtgtg taatcacagt tgtcgcagcg cccgctgcgg gcatccggat 1209301 attcattgaa ttcgtaaaca atcgatgtat cgtagccttt tgtttcatat tcttcttttt 1209361 tggtttccat gtcgatcctc cgttacaaga cgtgtctgct gtttatctta cagcaagctt 1209421 ccggcgtatt caatggattt taggaggttg ggtttatctt gatttctccc ttggtttgcg 1209481 ccaaaatagc tttattaagc ttatatacat aaaaagccta tgcaaagagg agaggaaacg 1209541 ggtatgggaa aagggttact tggaaaacgc gtggcaatcg gtggctcacg aaaaacggaa 1209601 gaaattagta caatcattga aaaacagggc ggaatacctg tcatccggcc tctccaaggt 1209661 acagtttact tagcagagaa gcaggtggag ccggatttgc ggacgtttgc ggaagaaaaa 1209721 gctgactggg tcattttcac gacaggcatc gggttggaga ctcttgtcga tatggcagag 1209781 aaaattggac tgaaagatga gtttctgcag gccattcgcc aagcgaaagc ggcatgccgg 1209841 ggatacaaaa cgctgtctgc gctgaaaaag cttggaatca caccggaagc ttcggatgaa 1209901 gacgggacaa caagaggctt aatccgttcc ttggagcctc acgacttttc aggaaaaaca 1209961 gtcatggtgc agcttcatgg cgaaaaagcg ccggctctca tggcatttct tgaagaaaaa 1210021 ggcgcgtctg tcctgccgat tctgccttat cagcacatcc cgccggagga ggaaacggtg 1210081 gagcggttat gccgagagct gatgaacgat gaggtcgatg ccgtttgttt tacaacggcc 1210141 attcaggttc gttccctgtt tgattttgcc aaggggcgag gttatatcaa tgaagtgaag 1210201 aaggtattcg aagaacgcgc catcgcagct gctgtcggaa aagtgactgc tgaagcactg 1210261 cgggaagagg gcattacgag actgcttgcg ccagagattg agcggatggg tgcgatgatt 1210321 gttgagctgg ccaagtatta tgaagaaaag gaataacaag tacaaaaagc cgcttttccc 1210381 tcggaaagcg gcttttgtct gtcattcatt ttgcttcagc tgctgatgaa cggtgaataa 1210441 tgatgggtat gtcagcacgc ttaagattac acaagtcagc gcggctgagg ccatcgttgt 1210501 aaacacgatt aagagttgaa agcgtactgc ctgaatcggg tccgcgccgg ctagaatctg 1210561 gccagtcatc atgccgggaa gctggacaag acccagtgtt ttctggcttt cgagcgtcgg 1210621 gatcatactc attttcatcg ctgaggtaag aatgcgctgt atggattgct tcggtgtgcc 1210681 gccaagtgac aatattaatt gaatttcttc tttgcgaacg ccgacttctg agttaagccg 1210741 gtttagaaac aaacttgaga gcaccatcga atttccgatg accatcccgc tgatcggaat 1210801 gacatatcgt gccgtaagcg gaatgatatg aagagacagc agaattccct gcgtcacaat 1210861 ttctacgatt gctaacgcgg caaacaccct ccaaaacgaa ccgatagtat ttttctttcg 1210921 cttgatgaca ttttgcgccg ccaccgcgag cattaacagc accatcagca ggataaaaac 1210981 agggtggtct ccgcgaaaaa tcagcgacaa aacataaccg atgataagca gctgcaccgc 1211041 ggcccggatg gtggcgatga tcatgtcttt ttctacaccg gctttaaagg attttgataa 1211101 aaacaaggcg atcaaaacaa agatcatcgt taaagagaga gaaaggtaat ccattaccga 1211161 gtgcctccct tcaaaaattc tttcgctgct tcatgctgcg gagcggagaa aaatgtgtcg 1211221 gtttcagcga tttcaagcag ccggccatct gccataaacc aaatggtatc ggctattcgt 1211281 tttgcctgct ccatattatg agtgacccac atgactgtcc attttttctc ttgatgctga 1211341 cgtttgatca gttcttcaat ctcaagagca gagaccgggt ccaaggccga tgtgatttcg 1211401 tccaacaata gaatggagga aggatttgag agcgttctgg ccagtgacag tctttgccgc 1211461 tgcccgcccg ataagtctct ggcgcttctg tctaacaact ctggcggcag ccctgcaagc 1211521 gaagccagct tttcaggaga gtacagctgg gattgatgca gcctttgtac aagacttaaa 1211581 ttgtcacgca ctgtcccgtc gagcacggga gccgattgaa acgcgagggc tgccgttcgc 1211641 ctcagctcat tgacattcca ttctctgact tcctttccgt atatgttgac ttcgccgctg 1211701 tcaggcgttc tcattaaatt acacatagaa aggagggtgc ttttgcctga gccggaaggg 1211761 cctaaaacgg ctacgattgc accctgttga atgtctccgg tgacatcctg cagcacatca 1211821 taggtttgtc catcttgttt atagcttttt ctgactgatc tgaaggagat ggctggtatg 1211881 ttttgtgttt gatcgtttgc ttccattaca ataatcacct ttcaatataa gtaggctgac 1211941 attatattta actataacgt gaaacagatt ccttttggta gcacaaataa aggagaacag 1212001 gctttcaccc attctcctgc agatgctacg cagtcagatt tgactgtgct ttctttttcg 1212061 gttttctcgg ctgtgaagcg aaggtatgta acatcatccc cgctattata atgaacaaac 1212121 cggcaaatga taatagagat gggaaaacgc ctgacagcag aacaatttca ccaagcagcg 1212181 cgaaaatcac ttcaccggat tgagtggctt caacagctgc gagtttttgc ggattgtctc 1212241 ttaccatatc agtggcccag aaaaataaaa ccgtcgcaat gatgcctgag ctgacggcaa 1212301 cgataaagga ttgaacggtt tgacttgctg ttggaaggcc atctgaccac cagccgtaag 1212361 ctgctaatat aagccagaat ggaaggcttg ccaatgtcat tccaagcacg cgctgaaatg 1212421 tatcaagccg gcctccgtat tcttcgagca ttcttcggtt tcctaacgga taggcaaaag 1212481 ccgcaatgac aaccggcagc acactgaaaa gcagcatcct cccagaaagc gattctgcat 1212541 gctgaagctg aatcagagcc gctccaatca ggatgatcac agaagtgcca agtgaaacca 1212601 ggggaatctt ttggcgaatg agctgcggac cgcccggcat atcttgtttg acataaaaca 1212661 aaggagataa gagcaccccg gctacaattg taatttgcca ggttccagct atgagccacc 1212721 ccggaccgta tgcagccgca aatgtaatcg gtgcgtaaaa aagcacgaaa ccgacgaagc 1212781 tccatttgat ccaataaaac ggctttttcc tcatttctag taagagaggc gtgaatgtcc 1212841 ctctcatgat gacaatcaaa cataaaaatg gcaccataaa aataaagcgc agcgaagagc 1212901 tccaaagcca gctgcctcct gataactcca tcgctctgtt taatataaag gtaacggcga 1212961 aaaagagtga agccaatatt ccgataacga tagctttcat gatatccctc attctggcat 1213021 tattttttta tactatacta ttcggtatca tgcagatcaa tggaatcatg agaaaaacat 1213081 catgtttggc gaaccgctat atgtggaaga caaaaaaggg aggtgaaatt gatggaaaga 1213141 gagacacaga catacttctt tccggatgac ggcaggattc cgaatcaccc tgattttccg 1213201 ctcgtggtgt atcaaaacgc gcttaaggac accggactgg cagagcggat cgtcacccgg 1213261 catggctggt caaacagctg gtcagggagt gtttttccat accatcatta tcacagcaat 1213321 acgcatgaag tcctgattgc ccttaggaga gaggctgtga ttcagtttgg gggagaaaaa 1213381 ggggctgcca tccctttcaa atcaggcgac gcagtcgtga ttccagccgg agtcggacat 1213441 aaaaagctca gctcaagccc cgattttact gtccttggcg cctatcccgg tggcgttcag 1213501 tacgatatga agacggggaa gccgaatgag cgggaggaag cggtcaaaca gattaagcag 1213561 gcggcgttgc cggcgaatga tccgatcaca ggaaaaagag agcctctatt ggaaatatgg 1213621 gtaaagtgaa ggggagaaat tgctggattg tcaataacta gtgccgcaga aacgatatga 1213681 catgagctcc atataaatta atttcataat cgaagcaatt cacgttcaaa ttttgttcaa 1213741 aaagtgttat catatagaag gtaatcgaat tggagttttt tgtgtttgct attttcagag 1213801 agagtaaagg attttgactt attcaattgt ttatttttag ataaaaataa tactgaatat 1213861 ggcaagatga aaaactgggt agtaaacatt tatttttgta aatgattgtg catgaattca 1213921 caatccttat tcttatgcct taaaagcgtg agacagggag aggcactacc ctttccaaaa 1213981 aaatcagcaa actgcttata gtaaaggaga attggatatg ccagaaacaa tcgatcaaac 1214041 aaatgcgtct gtcagccaaa gccagcaaga tcttattgat cagctattaa agccagaagt 1214101 tcaagaatca ttgactgttt tagttgacca gcttccgaag ctgactgagt tagtgaatat 1214161 tttaacgaag tcttatgatt tcgctcagtc tgtagcgact gacgaagtgt taaagagcga 1214221 cacagtcggt gcgatcactg aaattctcga gcctgtaaaa gaaacagcga aagaagtagc 1214281 tgcgactgcg atcgaagcaa aagaccgcgc ggaagcaagc aacgaaacaa ttggactttt 1214341 cggccttctt cgcatgctga aagatcctca agctcaaaag ctgttccgtt ttgctaacag 1214401 ctaccttgaa gtcatgaacg aacgcgaaaa ccaaaaataa tctcagattc aaattgatat 1214461 aaaggacgga ggatatacga tgtcaaaaca tattgtcatt ctaggcgctg gttatggcgg 1214521 agttctttct gctctaacag ttcgcaaaca ttacacaaaa gaacaagcac gcgtgacagt 1214581 ggtaaacaaa tacccaactc accaaatcat tacggaatta caccgccttg ctgcaggcaa 1214641 cgtgtctgaa aaagcggttg caatgccatt agaaaaactt ttcaaaggca aagacattga 1214701 tcttaaaatt gcggaagtaa gctctttctc tgttgataaa aaagaagttg cgcttgctga 1214761 cggttctaca ttaacttacg atgcgcttgt tgtaggtctt ggttctgtaa cggcttactt 1214821 cggcatccca ggtcttgaag aaaacagcat ggtattgaaa tctgctgccg atgcgaacaa 1214881 agtcttccaa catgttgaag atcgtgtgcg cgagtactct aaaacgaaaa acgaagcaga 1214941 tgcaacaatc cttatcggcg gaggcggctt aacaggtgtt gagcttgttg gtgagcttgc 1215001 tgacatcatg ccgaaccttg cgaaaaaata cggcgtagac cataaagaaa tcaaattgaa 1215061 acttgttgaa gcaggtccga agatccttcc tgttcttccg gatgatctta tcgagcgtgc 1215121 gactgcaagc cttgaaaaac gcggcgttga gttcttaaca ggtcttcctg ttacaaatgt 1215181 agaaggaaac gtaatcgatc tgaaagacgg atctaaagtt gttgccaaca catttgtttg 1215241 gactggcggc gtacaaggta acccattagt cggtgaatca ggcctagaag tgaaccgcgg 1215301 acgcgcgact gtaaatgact tcctgcaatc tacatctcat gaagatgtat tcgttgctgg 1215361 agacagcgca gtttacttcg gtccagacgg ccgtccatac ccgccaactg cacaaatcgc 1215421 atggcaaatg ggtgagctga tcggttacaa cctattcgct tacctagaag gcaaaacgct 1215481 tgaaacattc aagccagtaa actctggtac acttgcaagc cttggacgca aagacgcggt 1215541 tgccatcatt ggtgctaatt ctacaccgct taaaggtctt cctgcttcct tgatgaaaga 1215601 agcaagtaat gtacgatatt tgacacatat taaaggactt ttcagcctgg cttactaatc 1215661 cttttaatga atctggcatt gccaaaagca ttcctttccg agtgctttct ggcaatgtct 1215721 ttttttatgt ttatgacagc gttaacattt cattttcaaa aaagagattg atcccaaagg 1215781 aatataaagg taaaataaaa acaaatcaaa atgttaacgt taacattttg aaatagaatg 1215841 aaagacggtg aggacatgga acccttcatg ggcaaaaact ttttattgaa aaatgaaacc 1215901 gctgtcagcc tctatcacaa ttatgcgaaa gacatgccaa ttattgatta ccactgccac 1215961 ttaagtccga aagaaatcta tgaaaataag acatttcaaa acatcacgga agcctggctg 1216021 tatggtgacc attataaatg gcgcatcatg agagccaatg gaattgagga gacatacatt 1216081 accggagatg cgcctgatga ggagaaattt atggcttggg cgaaaaccgt gccgatggcg 1216141 attggcaacc cgctctacaa ctggactcac ttagaattgc agcgtttttt tggcatttac 1216201 gagattttaa acgagaagtc cgggtcggct atatggaaac agacaaataa actgctcaaa 1216261 ggggaaggct tcggggcaag ggatttaatc gtgaaatcaa atgtaaaggt cgtgtgcacc 1216321 acagatgacc ctgttgattc tcttgaatac catttattgt taaaagaaga caaagacttt 1216381 cctgtcagtg tgctgcctgg atttcggccg gataaaggac ttgagatcaa tcgtgaaggc 1216441 tttcctgagt gggtgcaggc gcttgaagat gccgctgcca tatcgattac aacctatgat 1216501 gagtttttaa aggcgttgga aaaacgagtg cgattcttcc actcagccgg cggcagagtt 1216561 tctgatcacg cgatagatac aatggtattt gccgaaacaa caaaagaaga agctggacgg 1216621 attttttctg acagattaca aggaacagag gtttcttgtg aagatgagaa gaaatttaag 1216681 acatatacgc ttcagtttct ttgcggtttg tatgcggagc tcgattgggc gatgcagttt 1216741 catatcaacg ctttaagaaa cacgaataca aaaatgatga aaaggctcgg acctgataca 1216801 gggtatgatt caatgaacga tgaagaaatt gctaagcctt tatacaagct gctgaactca 1216861 gttgagatga agaaccagct gccgaaaacg attttatatt cactgaatcc aaatgataac 1216921 tatgtcatcg ccagcatgat caacagtttt caggacggta ttaccccggg aaaaatacaa 1216981 ttcggcacag cctggtggtt taacgatact aaagacggaa tgctcgacca aatgaaagcg 1217041 ttatcaaatg ttggcctttt cagccgtttt atcggcatgc tcaccgattc cagaagcttt 1217101 ctttcgtata cgcgccacga atatttcagg cggatcgtct gcaatttgat tggagaatgg 1217161 gtggaaaacg gcgaagtgcc gcgcgatatg gagcttctgg gaagcatcgt tcaggggatt 1217221 tgctatgaca atgcgaaaca ctactttcaa tttcaagaag agaaagcaaa cgtgtaacaa 1217281 agtgtccgct cagtatcgct gagcggatca ctatccgaaa attcttaaga cacagaggtg 1217341 gaacatgcga actgaactgg caaataaggt tgtgtcggtc gaaacggaaa aaaggctttc 1217401 attgaaagag aaaatgtcct atggctttgg tgattttggc aacggtttta tgtttgatct 1217461 cggccagatt tatttattga agtatttcac tgatgtagcg ggaatccccg ctgcgatggc 1217521 cggcggcatt tttttagtca gtaagctgtt tgcagcgata acagatccaa ttgtcggctc 1217581 atcaatcgat tatcgcaaaa acatcggcaa acgggggaaa ttcaggcctt atctattaat 1217641 cggcagcatc gtgcttgcgg tgcttactgt tcttattttt ctgtctccca atgtatcaac 1217701 gaccggaaaa ctgatatatg catatgcatc ctatatgatt tggggcatcg gctattcgtt 1217761 tgtgaatatt ccgtacggct cattaggggc agcgatgact caaaattctg aggaccggac 1217821 ctccatttcg acgttccgcc aaatcggatc acttggcgcc ttgtttatca caagtgtggc 1217881 cgtgatgccg ctgctcgtca agtttgataa tccgaaggtc ggctacccgg tggtcatggg 1217941 cttgttcgcc gcgctcggtg tgttttggtt ttatatttgc taccgcaact gcaaagagcg 1218001 cattatcata tcggaagcac ccaaagaaaa attaacactc tcatctgtcg tcaaaacatt 1218061 tattacaaat aaaccgctgt taacccttgt cctgatgacg attttttcaa tttccgcata 1218121 caacattaaa tccgccatgc tcgtctattt cgcacaatat aacttgggca atgttgaatt 1218181 aatggcttat atgaacttca tcattattgg ttcttccttt ttgggcgtcg tattccttcc 1218241 aaagctcgtc aagatgtttg gaaagaaacg aacggcaatg atcggctttg gcatcagtgt 1218301 ggccgcggat ctgatcaact ttatgcttcc atctaacgtt tatgtgttta caattctcgc 1218361 cagtatcgcc tttatcggaa tcagtatccc aaatggcatc acgtgggctc ttgtctccga 1218421 tattatcgac tatggcgaat ggaaatccgg tgaacggaag gaagcaacga catattcact 1218481 tttcaatttc tcaagaaagc ttgctcaatc tttgtctggc tttctctcgg ggatcggttt 1218541 ggggattatc ggctatgtgc cgaatgcagt ccagacagca caggcgctga ttggcatcaa 1218601 agcgctgctt cttctgtatc cggccattgc tttggcatta gcgatgttca ttatcggctt 1218661 tctttataaa ctcacagacc agcagcatgc tcagatcgtt caggatcttc atcaaaagag 1218721 ctgacaatat aatataaaga atatttaaaa taatttgtaa ataaaatgtg tttgtagggg 1218781 tttcgcttgg agagtgccca aaaaactgaa aaggaaggag gcacttgctt gaaaacgata 1218841 acaattgcag ctgaagaagc aaaggaactc gtttggcaaa agctggacgg tgccggtttg 1218901 aatgaacgag atgctgaaaa agtggcagat gttctcgtgc acgctgattt gcgcaatgta 1218961 cattcgcatg gcgtgctgca cacagaacac tatgtgaaca ggcttttagc gggagggatc 1219021 aatcctgggg cacagcctgt ttttaaagag acggggcctg tgaccggggt gcttgacgga 1219081 gacgatggtt tcggtcatgt gaattgcgac atggcgatgg accatgcaat tgacatggcg 1219141 aagaaaaaag gagtcggcat ggtcacggcc gtaaacagca gccattgcgg agcgctaagc 1219201 tattttgtgc aaaaagcggc tgacgaaaag ctgatcggaa tggcaatgac gcatacagac 1219261 agtatcgttg tcccatttgg ggggaggact cctattttag ggacaaatcc gattgcttac 1219321 ggagttccgg ctaagcataa aaaaccgttt atcctagata tggcgacatc caaagtggct 1219381 tttgggaaga ttctgcaggc ccgtgaagag ggcaaagaaa ttcctgaagg atggggagtc 1219441 gatgaaaacg gagaagcagt aactgatcct gacaaggtcg tctcactttc aacattcggg 1219501 ggcccgaaag gctatggact atcgattgta gtggatgtgt tttccggatt gctggcgggc 1219561 gcggcttttg gccctcatat tgccaaaatg tacaacggcc ttgatcaaaa aagaaagctg 1219621 gggcattacg tttgcgcgat caatccatcc ttttttactg actgggatac gtttttagag 1219681 cagatggatg ccatgattga tgaactgcag caatcaccgc cggctgttgg attcgaaaga 1219741 gtgtatgtgc ccggcgagat cgagcagctg catgaagaaa gaaataagaa aaacggaatt 1219801 tctatcgccc ggagcgtgta tgaattctta aaaagcaggt gagtaaaatg aaagcggttc 1219861 aagtgcgaaa agcgtatgat ctggtgacag cggaggtgaa gaagccagtt ctttcaaagg 1219921 atgatgaagt gctcgtgaaa gtcaagcgag tcggcatttg cggttcagac atgcacattt 1219981 atcatggaac gaatccgctc gctaccctcc cgagagtcat cggacacgag gtaacgggac 1220041 aagtggaggc agttggtgcg aatgtacaga gcctaaaacc cggtgatcat gtggtgattg 1220101 agccgatttc ttattgcgga tcgtgctatg cctgccgcaa agggcggccg aatgtttgcg 1220161 ccaagctttc tgtatttggc gtacatgagg acggaggcat gcgggaatat attgtgcttc 1220221 cggaaagaca gcttcacgcg gtctcaaagg acttgccttg ggaggaagca gtcatggccg 1220281 agccttatac gataggcgcc caggcagtgt ggagaggcca ggtggaaaaa ggtgataccg 1220341 tcctgatcca gggagcgggg cccatcggga tctgtgtgtt aaaaatggca aaactggcgg 1220401 gcgctgctgt catgatgact gacttgaaca acgagcggct ggcatttgcg aaagaaaacg 1220461 gcgccgatgc tgttgtaaat gtccaagcag aacatgttgc cgagcgggtc cttgaatgga 1220521 ctgggaatga aggagcaaac gtggtcattg atgctgtttg cctgccggag acttttgcac 1220581 tttcaattga ggctgtgtca ccggcgggac atgtggttgt gcttggattt gatgaaagag 1220641 cggctcagat ttctcagctg ccaattacaa aaaaagaagt cacgataacc ggatcccgat 1220701 tgcagaccaa tcagtttcca aaagtggtag agcttttgaa tggaggccgg ttaatgcata 1220761 acgggctggt gacccataca ttttcagttg atgacgttca tcatgcattt cagtttatta 1220821 aggagcatcc agatcaggtg cggaaagccg tcatcacgtt tgattaaatg actgaatccg 1220881 gaggtgcgag catgaatatg acattccgat ggtatggacg aggcaacgat acagtcacac 1220941 ttgaatacgt gaagcaaatt cccggtgtca aaggcatcgt ttgggctctc catcaaaagc 1221001 ccgtcggcga cgtgtgggaa aaagaagaaa tcagagccga aactgaatat attcaatcct 1221061 atggttttca tgctgaagtt gtagaaagcg tgaatgttca cgaagcgatt aaacttggga 1221121 acgaagaacg cggccggtat attgaaaact acaagcaaac gatccgcaac cttgccggat 1221181 ttggcgtgaa agtgatctgc tataatttta tgccggtttt tgattggaca cgcacggaca 1221241 tgttccggcc gctagaagat ggatcgaccg ctctgttttt tgaaaaggcc aaggtggaaa 1221301 gccttgatcc tcaagagctg attcggacgg tggaggaagc atccgacatg acactgccgg 1221361 ggtgggagcc cgaaaaattg gctcggatca aagagctttt tgctgcctac agaacggtcg 1221421 atgaagaaaa gctatgggac aatttatcat tctttttgca ggaaattctt cctgttgctg 1221481 aggcctatgg tgttcaaatg gccattcatc cggatgaccc gccgtggccg attttcggac 1221541 tgccgcgcat tatcacagga gaggcaagct ataagaaact gcgggcgata tcagattcac 1221601 cgtctaattg tatcaccctt tgtacaggtt caatgggagc caatcccgct aacgacatgg 1221661 tggagatcgc taaaacgtat gccggcatcg ctccattttc acatattcgc aatgtgaaaa 1221721 tttatgagaa tggcgatttt attgaaacat ctcatttaac aaaggatggt tcgatcaaca 1221781 ttcaaggcgt gatggaagaa ctgcataagc aggattacga aggatatgtc agaccggatc 1221841 atgggcgcca tctttggggc gagcaatgcc gcccgggata tggcttatac gatcgggcac 1221901 ttggcatcat gtatttgaac gggctgtggg acgcttatga agcaatggca aaaaaagagg 1221961 tgggcatatg atcccgctgc atgagaacct ggctggtaaa acggctgtca tcactggcgg 1222021 cagcggcgtg ctttgctctg cgatggcccg ggagctagcc cgtcatggca tgaaggtggc 1222081 gattttgaat cggacggctg aaaaaggcca agcggtcgtg aaggagataa cggcggctgg 1222141 cggcacagcg tgcgctgttg ctgcggatgt gctggacagg atgtcactgg agcgggcaaa 1222201 ggaagacatc cttggccaat ttggcgctgt tgatctgtta attaacgggg ctggcggcaa 1222261 tcatcctgac gcgataaccg atgtggagac atatgaagaa gcgggagaag gccaatcctt 1222321 ttttgatatg gatgagaggg gctttctaac tgtattctcc accaacttca ccggtgcgtt 1222381 tctggcctcg caagtgtttg gtaaagaact gctgaaggcg gattcacccg cgatcatcaa 1222441 cctttcttcc atgagtgctt attcacctat gacgaaggtt ccggcataca gtgctgcgaa 1222501 agcatccatc aataatttta cgatgtggat ggctgttcat tttgccgaaa ccgggctgcg 1222561 ggtcaatgcg attgccccag gcttctttct gacaaaacaa aatcatgatc tgctgatcaa 1222621 ccaagacgga acgttcacca gccgatctca caaaattatt gcgggaacac cgatgaagcg 1222681 cttcggaaaa ccggaggatt tgctcggtac gctcctttgg ctggcggatg aatcctattc 1222741 cggttttgtc actgggatca ccgttcctgt cgatggagga tttatggctt attcaggtgt 1222801 gtaacgaaag cggtgcaaca gaaactgaac caacataggg gtgaggttga gatgttttca 1222861 aaagataagc ttcccgttat cctttttttg ttcctggcag gggtgattaa ttacctggat 1222921 cgctcggcgc tttccattgc agctcctttt attcaggatg atctcacatt gtctgccaca 1222981 caaatgggct tgattttcag cagtttttcg ataggttatg ccatttttaa ttttcttggg 1223041 ggcgtggcat ccgaccgcta tggggcaaag ctgaccttgt ttgtcgcgat ggttgtttgg 1223101 tcgctgttta gcggagcagt cgccctcgct tttggctttg tcagcctgct gattatacgc 1223161 attctcttcg gaatgggaga aggcccgctt tcggcgacca tcaacaagat ggtgaacaac 1223221 tggttcccgc cgacccagcg ggcgtccgtt atcggtgtaa ccaacagcgg cacgcccctc 1223281 gggggagcca tttccggccc gatagtcggc atgatcgcag tggcgttcag ctggaaggta 1223341 tccttcgttc tcattatgat tattggattg atatgggcag tgctctggtt caagtttgtc 1223401 aaagaaaagc cgcaagagac gatcaaggaa gcaccggcaa taaaagcaga aacgtctccc 1223461 ggagaaaaaa ttccgctcac cttttacctg aagcaaaaaa cagtcctgtt cacggcgttc 1223521 gcttttttcg cttacaacta catcctcttc ttctttttga catggtttcc gagctatctt 1223581 gtcgacgagc ggggattaag tgttgaatcg atgagtgtca tcacggtcat accgtggatt 1223641 ttaggattta tcgggctggc tgcgggggga tttgtttctg actatgtgta caaaaaaacg 1223701 gcccgaaaag gtgtgctgtt ctcgcgcaag gttgtgcttg tcacgtgttt gttttcatca 1223761 gctgtcctga ttggttttgc cgggcttgtg gcaacgactg cgggggctgt cactcttgtc 1223821 gctctgtcag tgttctttct ttatttgacc ggtgctatct attgggctgt cattcaagat 1223881 gtggttgatc aaaacaatgt cggttctgtt ggcggcttca tgcatttcct cgccaacacg 1223941 gcaggaatta tcggcccggc tttaaccgga tttattgttg accaaacagg cacgttttct 1224001 ggagcatttt tgcttgccgg tgggctggct gtcttcgctt cacttgctgt gattcgtttt 1224061 gtccgtccaa tcattggtaa gccagcggga acagaagctg agaatcctgt gtcttattaa 1224121 tctggaaata tagtgggaga ggcggtatgt ttgatgatac aatatacagt aaataatcgc 1224181 agccggtatg ataaggaagg gaattagatg gtaaccataa aagatatcgc aaaactcgca 1224241 aacgtatccc acactactgt ttccagagca ctcaacaaca gcccttacat caaagaacat 1224301 acgaagaaaa aaatattaga gctagcagag cagctcaact atacaccaaa tgtaaatgcg 1224361 aaaagtctgg cgatgcaaaa gtcgcatacg atcgggctat tctttacaag cattacaaac 1224421 ggaacctcac acagcttctt tgcagacact atcaaaggcg tcaatcaagc cataagtgag 1224481 gattacaatc tgtatgtgcg cggcattgat gatctgaaaa actatgactc cgttacaccg 1224541 atgagatatg acggcatcat tttaatgagc caaagtgaca ttgataattc ttttatttac 1224601 catattcgcg aaaaaaacat tccgcttgtc gtgctgaatc gtgatattga tgatcgtacc 1224661 atcacgaata ttttgtccaa tgacaaggaa ggctctcaag aagctgtaga atacttcatt 1224721 cagtccggac atcaagacat cgccatcatc gaggggatcg aaggctttaa atcctcccag 1224781 cagcgaaagg aagggtactt atccgcactg attcaacatc atattccgat caagcatgaa 1224841 tacagtgtca aaggacagta cgatatggaa agcggctttc aagcgatgga gcggctgctg 1224901 gcactgccga atcctccaac cgctgttttt tgttcgaatg atgacatggc aatcggagcg 1224961 atgaatgcga tattcgcaaa gggcctgcgc gttcctgatg atatttcggt gatcgggttt 1225021 gatgatattg ggttttcaca gtacatcacg ccaaggcttt caacagtaaa gcgcccagtg 1225081 gagaaaataa gcgtgctcgg tgcgcaaaaa ctcttgtcgc tgatcagcga gcccgaaaca 1225141 aaagcagaaa aaatcttgga aaacacagaa tttatggtgc gtgattcagt cagacgattg 1225201 acgacgtgat gtcccgtttt tcagcgggca ttctttatac agaaaaatgt taacgtgtgc 1225261 ataaagtgag agggaggcaa taagggtgca gaagctgaat aaaaatgtgt acgatcacta 1225321 tactcagtat ccagaaaaaa ttctccaatt cggagaagga aactttcttc ggggatttat 1225381 cgattggcag attgatcaat tgaatcaaca cactgatttt aatgggagcg tggcagttgt 1225441 ccagccaaga ggctcagaaa aaatcaaacg attaaatgag caagatggat tatatacact 1225501 ttttttacaa ggaatgaaag acggagaagc ggtaaacgag catatgatta tcaactcaat 1225561 cagccgggga attgacctgt tttctgatta tgaagcatac aaagaattgg catcaagcga 1225621 aaggcttcgg tttattatct ccaacaccac tgaggctggg attgtatgtg atgaaaaaga 1225681 tcgtttagag gataggccgc aaaaaacatt ccctgggaaa ttaactgcat ttctttactt 1225741 tcgctatcag gcttttaaag gagatcagac aaaagggtgt gtcctgatcc catgtgaact 1225801 gatcgagaat aacggtgaaa agctgaggga aacggttctt cattatgcac atctgtggaa 1225861 gctggaggaa ggatttacac agtggattca tgaggccaat acattttgta atagtttagt 1225921 agaccggatt gttccgggtt ttcccgtcga cagcattgat gagatcacgg cagatcttgg 1225981 ctatcaggat gatttgatag ttgtgggaga gcaatattat ttgtgggtta tcgaggggcc 1226041 tgattggatt ggaaaagaac ttccctttgc ggctgcaggg ctgcatacaa agatcgtcag 1226101 cgacctcacc ccataccgga ctaaaaaagt aagaatttta aatggcgctc atacagcaat 1226161 gacgccagtg gctttattat acggcttgaa gactgttagg gatgcagtcg agcatccgga 1226221 agtggggcga tttataagag agctgattga tgacgaaatt cttcctgttt taaaaatgga 1226281 aggtctttct cagtatgctg acgatgtgct gaaccgtttt aaaaacccgt atattaagca 1226341 ttacctggaa agcattgcat tgaacgccat ttccaaattc aaaacgagaa acctgccgac 1226401 tcttaaggaa tatgctgaac aaaagggaca gcttcctgaa cgcttggtgt tttctttcag 1226461 cgctcttctg tatttttatc atgataacga gacattgcag gatgatccgg cagttcttca 1226521 atttttcaaa gaggtttggt gtcaggagga tggcgacatg cttcggattg catcaagagt 1226581 gttaggcgaa cagcggctgt ggggggcaga tctcaatgag ataccgaagc tgactgatag 1226641 agtcgctgtt tacttgaatc atattcatga gctgggcatg cagagggctc ttgaacaata 1226701 ctgcatacaa gggggagagg tacgttgaag tcgtttataa agattcataa gcaagataat 1226761 gtccttcttg ctctgcggga tattcaaaag ggagagaggc tgcatgctta cggcgtgtcg 1226821 attgaagtaa aggatgatat aaaaagaggc cataagattg cattgcagtc tatcaaagaa 1226881 aacgacagca tcgtcaagta cgggtttcca atcggtcatg catcacaaga tatctcgatc 1226941 ggagagcata ttcatgtcca taatacgaaa acaaacctgt ctgatatcca attatacagc 1227001 tatacaccga gatttgatga aaatccgtat tctaatgaga accggacgtt taaaggtttt 1227061 agaagagaaa acggagatgc gggtgtacgg aatgaattgt ggattgtccc aactgtcggc 1227121 tgtgtcaatg gaatagcaga aaaaatgctg cagcgttttg tcagagaaac aggggatatc 1227181 gctccatttg ataacgtact ggtgttaaag catcaatacg gatgctcgca gcttggcgac 1227241 gatcatgaaa atacgaagca gatcctgctg aatgccattc gccatccaaa tgccggcggc 1227301 gtcttggtgt tagggcttgg ctgtgaaaac aatgagctgg caagaatgaa ggaagcactg 1227361 caagatgtga acttgaagcg ggtgaagttt ctggaatccc agtcggtgac cgacgaaatg 1227421 gaggcaggcg ttgctttgct gaaggaaatt catgaagcgg ccaaaggaga taagagagaa 1227481 gacattccgc tgtctgaact gaagatcggg ctgaaatgcg gaggttcgga cggtttttcc 1227541 ggcataaccg caaacccgct gcttggacgt ttttcagatt atctcattgc acagggaggg 1227601 agtactgtgc tgacggaagt accggaaatg ttcggcgcag aaaccatcct gatgcagcgg 1227661 gctgccaatg aagaagtgtt tcataagata gtcgatttaa tcaatgattt caaacaatac 1227721 tttattaaac atgatcagcc ggtgtacgaa aatccttcac cgggcaacaa agcgggcggc 1227781 atttctacac ttgaggataa atcgctgggc tgtacgcaaa aagcggggat ttctcctgtc 1227841 acggatgtct tgaaatacgg tgaagtactc aagacaaaag ggctgactct tttgagcgca 1227901 ccgggcaatg atttgatcgc ctcctccgca ttggcggctg ccggctgcca aattgtcctc 1227961 tttacaacgg gaagaggcac gccgtttggc acctttgtcc cgacggtgaa agtagcgaca 1228021 aacaccgagc tgtatgaggc gaagccgcat tggattgatt ttaacgcagg ccttttagca 1228081 gaggatgatg ttcatgagga atatgtgctg cgtgagttta tccactatat gattgaggtg 1228141 gcaagcggcc agcttgtgaa ccatgaaaaa aatgatttca aagaactcgc catttttaaa 1228201 tcgggtgtga cgttataata agaaaaggct atccttcaag cggatagcct tcttcattaa 1228261 atcaatttta aaccgctgac taaaataatg gaagccataa taaattgcag tggacgcggg 1228321 gagaatcgag gcgaaagatg gctcccgatc agtacgccgg gaattgaacc gaggagcaga 1228381 ttagctgcca gcatgtaatc cacgcttccg aagcttgcgt tcaaaatgcc tgctgccgta 1228441 acaagaagaa aagcatgcgc gatatcggtt ccgacaatct gtgacgcttt catgttaaat 1228501 aagtaaatca tggcgattgc aaataatgag ccggacccga ttgatgttaa tccgacgata 1228561 aacccaaaca caacaccaat aagaattgtc agcgccctct tattttcaag cggcatcagc 1228621 tgccagcggt tggggcgaag ttttctatcc aaaaacaaac gaacgatgat tgaaatggca 1228681 accagcgtta acacatatcc tagagcgtgc ttaataattt cttcctgatg ctggtgaaag 1228741 gcggggaaca aatgcaatat gccaatggct agcgaagcac tcggaatacc gccgatggct 1228801 aagtatttta ccaatttaaa gttaatcgtt ttctgccgcc aatgggaggc aacgccaaac 1228861 agctttgtga tcgagttata tacaagatcc gtaccgaccg cgatggaagg attaattcca 1228921 agcacaatta aaaggggagt taataaggcc gctccaccca ctcccgtcaa tccgactaag 1228981 gctccgacaa acaaacccat caatatgatg cttacactca tgataaaggc ctcctgaaaa 1229041 cccgactaga attcacccga atcttattcg cgttggtcaa gtattaattg taagtgctcc 1229101 atcggctgct gaaaaacccg agctctatcc gctccctgat ggtatcattc aattgacaac 1229161 accttataca tcaggagaac acgtctttca ggtgcaacga gcacttgcgg ctctgtattt 1229221 ttaccctgat aaaggcgctg ttaacaacgg aattgacggc gtttacggac cgaaaacagc 1229281 tgacgcagtt gcccgttttc agtctgttaa cggtctaact gctgacggta tctacgggcc 1229341 tgcgacgaaa gagaagatcg cagcgcaatt aagctgatca aagaccataa aaatcccgga 1229401 gccgctccgg gatttatttt ttcttcttca acttttttat aattccagca ctgcgctccc 1229461 tcacccgaag cgagtacccg gaaagcccaa accttccgta atcaacaaac ttcacacgcc 1229521 tcaccaattt tttcactgta tcacctgaca ttatcctctg tttgtattta ttatatgtca 1229581 ccctttaaga aaaggaataa ggacaagagc tgttttccct tgtcctttta gtgtgatcat 1229641 gctttttttc gtttatactc gtcaatcagc cgttcgtttt ctttgaagat tcttgctgta 1229701 tgcggactga cttgatagct tgcgacactg gtggttgaac gttttttcag gattttaaac 1229761 ggcttcgccg ctctgggctc gcatctgttt tgaaacgcac gttccattat ccttcacctt 1229821 cctcctcaat tggcagcacc aaatcatata tgctcgttaa tgacgtaaat agcaaataat 1229881 caaattccgt gacaatgctg tcagacgtca gcttgatgac atagttctgt gtctcgatgg 1229941 taaaagggat gagaaccact tttccgtatt ggtcgtaata aacatccttt cgatcgagcc 1230001 gtgtttgtac atctgccgga tcatccatat gctcggttaa ccggtcttta tcagcctgtg 1230061 tcgaatagtg gcaaagagaa gccgttaagt tcattttatc agcataggtt ttcagcagct 1230121 tatcaatacc ttcagcataa gcatctatac ttccataata aacatggatc ggttcgtttt 1230181 tcaataggta ttggtatgtt ttcagccgat tgagatacat gtggagcatt tcgttgtttt 1230241 cttcaagaat ttctcttgtg tctgtttcaa gctcgctgcc ggccagtttt ttgacatatg 1230301 cacttaagaa gataaaagca tcaatcaaag caaaactgac tgcgacaatg agataccgtt 1230361 cccagtgggt aaatagggaa gtgggctcat atgtccagta taccatagcg cccagaacaa 1230421 acagcaaata ccaagttttc cgaatggcgg acattttttc tttgaccttc gcttcgaaac 1230481 gccacgtggc atacacgtat aaccccagtc cggccacgat gcaccagacc atgatctgaa 1230541 agaataaaac catattcgaa tccctcacat ctgaaatagg ttctgcttat tgtattcgag 1230601 agatccggat ggttttcctg ttccatcaaa aaaaccgctc ctttgacaga agcggtgtga 1230661 cattaaaata tcatatttaa aataaagtag gcgatggcac caagtgtcgc tgaaatcgga 1230721 agcgtgatga cccatgtaat gagcattcgc ttggccgtac cccagtttac gccttttacg 1230781 cggtgggacg caccgacgcc aagaattgat gaagaaatga cgtgggttgt actgaccggc 1230841 aaatgaataa acgtggcgcc gaaaataatg gctgctccgg ttaagtcagc ggaaacaccg 1230901 tttaccggac ggattttcat gatctttccg ccaacggttt tgatgatttt ccagccgccg 1230961 attgatgttc cgagacccat ggctgtcgcg caggcgaatt gcacccaggt aggaatatca 1231021 ttagcagaag tatgtaaatt cgctgtgatg agagccattg tgataattcc cattgctttt 1231081 tgcgcatcgt ttgttccgtg tgtatacgat tgcagggcag ctgttacaat ctgcactctg 1231141 cggaattgct tattcgtttt cgccaagttg ctgtctttga aaatcagctt aacgatgcta 1231201 taaagaataa aaccaaggac aaaggcaata attggtgata gaatcagtgc ttcaatgatt 1231261 ttaatgaagc ccttatagtt taacgctgca aatccggctg ccgcaatggc tgcaccggca 1231321 atagcgccga tgatggcatg ggatgagctg cttgggatac cgtagtacca tgtgataagg 1231381 ttccaggcaa ttgcagcgag tagcgcagcc aaaatgacaa cagagccatt ttccagcgta 1231441 taaggatcta cgatgtcttt cgtaatggtt ttggcaacac ctgtaaacgt cattgctccg 1231501 acaaagttca tcacagcagc caatataatg gcatggcgcg gttttaacgc ttttgttgat 1231561 accgaagtcg caattgcgtt tgccgtatca tgaaacccgt tgatgaaatc aaacgccaga 1231621 gcacaaatga ctattagtat cgttaatatt aatagaatat ccatttttac ccctcgttac 1231681 gcgtttttca taatgatggt ttcaagatta ttggcaacac tttgacaaga gtcggcgatt 1231741 tcttcaagcg tttcgtatat ttcacgatat tgaatgactt tgattggatc tgtttcattt 1231801 ccgaaaagat tctttaatga ttttctgtgc aagttgtcac aactgtgctc atactcttta 1231861 attttgattg cgtgaggctg aatatccttt aagcgatttt ctgccagcag ctcgatcgta 1231921 atcaaaatct ctttcgcaca ttctctgata tatccgctga atttatcaat atgctcgtct 1231981 gatgaagtaa ttgagaaaat ctccatcatg gcagagaaat gttcgattcc gtcaagcaca 1232041 tcatccaagc tgtttgtcag ctgaaggata tcttcgcgct caataggagt gatgaacgct 1232101 ttgttaagct ctttaatcat gacatgaaca tgattgtcac cttttgtttc atattccttt 1232161 aacgtatctg caaattcttt aagagtcgtt tggttagtga ccttaaaatt cacaaaatat 1232221 tctgcagttt cgtctatgtt ctttgcaatt tctgttaaaa ggagtgagaa cttatctttt 1232281 tttcttctta tcattaaaaa ccctccatag tttgaatgaa caatgcacac atcaaattat 1232341 tatatagcct tttgtcgaaa aaaaacaggt aaagtcgaaa aaaacgtatc ttgacttttt 1232401 tgataaatcg tgtctcctta ttttgaccta cttcgcttta aaaaaacgac ccaagtttgc 1232461 aaaaactttc tgcttaacgt aaaaagtata tcaaaagttg tgtttttcct gtcaactttt 1232521 atcttctgtt tcaccaaaaa acggttccct aaacaaggga accgttttat cagcttgctt 1232581 ttcgtttttt catcccgtaa taaacaggca gtccggcaag gccgatgagg atggataatc 1232641 cgcagctcat tgtatctgta atgagtgtgc tgcctaacac aaagaaggag cccgcgattg 1232701 ccagaattgg cataaatgga taaagcggaa cactgtaggc gcgcttttct ccctttgctc 1232761 gcttgcggag aataaacact gcaaaaaagg ccatcacata aaaaatgtag atcatgaaaa 1232821 tggagatttc tgagagctta tcagggttgc tgatcagcat cataatcaaa gccaaagcaa 1232881 tttgaaaaga aatcgcaatc catggtgtgc ggaacgacgg gtgtacatgt gacagttttt 1232941 cagcaaatgg aagctgtttg cgttccgcca ttgcaaatga aacacgcggg aaagaaagca 1233001 cctttccatt taagcaccca aagatgctga cgataatccc tacactgatc agctttccgc 1233061 caattgaacc gaacagcatg gttgcagcgg tgcttgtcgc attttcacca agcgtgacaa 1233121 tttcgttcgc tgacaggatg tgaagcaatg caaaattaat gaaaatatag atcgccgtta 1233181 caattaataa tccgcccgtc atagcgcgtg gcagcagctt ttcgggattt ttcatttctc 1233241 cgccgagagc ggcaaggaga atccatccgt cataagcaaa caacgtagct aaaatagccg 1233301 ccccgaagtt catatcagaa atgctttcgt ttactgctgt gaagatgtgc tgatcgcctt 1233361 tccaaaggcc aaagacgatg atgcaggcaa tcggaatcag ttttccgatc gttgtcagcg 1233421 tttggacaaa accgccgtat tttgtaccga taatattaat gacgcataaa aagagaactg 1233481 ctataattcc aatgactttt gatagtccag atccccagcc gaaaagattc gccattaaag 1233541 atccaaaata taaacccagc gcgccaataa tcgccgggcc gtaaatgata atctgcaccc 1233601 agccgcacaa aaatccccaa aactcgccgt acacttcttc aaggtacgta taaagcccgc 1233661 cggtttttgg aatctgcgtt ccgatttccg cgattgtcaa accgcccgcc agtgttaaaa 1233721 taccgcctaa cagccaggcg aaaagcgcca tttttgaatc acctgaataa gcaagcacag 1233781 cgccgggctt cataaaaaca ccagaaccga taatggttcc gatgacaaga gtaagggcaa 1233841 acaagaggcc tatctctttt ttcaaaccgt tgtcttcagt atgcatgtcc ttaacctcct 1233901 atgatgttga agcttcatgt tgaagaatct attttttcat attgtaaacc ctattttaga 1233961 aaagtgaaat aaaataaatt ttctgatttt cgaaatttgc tttgtgtaca gcagataaaa 1234021 ctgtagaaat acctgtttta atggtctata aacgaataaa attcataatt tttatttaca 1234081 aagttcgtgt tttatgtatt aggattttag ccggtacaga ggggagatga gaattcagaa 1234141 aatgaacgaa ccttcggtga agctgatatg ttgactttct catgcgaata aaatactttg 1234201 ttattagaac aataaatata caattatgat atgatatctc gaaatcgaga taaaataacc 1234261 tggagggaca gcatatgaaa gttaacggca ttcaccacgt atcggcatta acggccgacg 1234321 cacaaaaaaa cttggatttc tataagaaag tattaggatt aaagctcgtc aaaaaatccg 1234381 tcaatcagga tgaaccgaca atgtaccatc tgttctacgg agatgaagtg gcaaacccgg 1234441 gaactgagct gacgtttttc gagattcccc gcattgcacc gtttcatgcg ggaacaaaca 1234501 gtatttcttc tattggattg cgcgttccag gcacagaagc cctgcattac tggaaagaac 1234561 gttttgaaga gcagcaagta acgcacagcg gcatctccaa aagagccgga cgtgacatat 1234621 tggcatttca agatcatgag gggcagcgac ttgtgctgac tgctgatgag gaaggaaaag 1234681 gatatggcct gcctgttaaa cagagcggca ttccggaaga attttcgttt cgcgggttag 1234741 ggccggttga actgactgtg ccatatgctg aaccaacttt acacgtattg acgaatattc 1234801 ttggatttac agaaatcagc cgtgaaccag tcgaagggca aggaaccgcc gttattctgg 1234861 aatcaggaga aggcggtgct gcaacggaaa tccatttaat agaaagaaac gatcttccgc 1234921 gagagcgtca aggcaaaggg agtgttcacc acgtcgcatt tcgggtaaga gatgaagaag 1234981 aacttgccgg gtggcaccgg atcatcagcc gcgaaggctt tagcaattca ggcatagttg 1235041 agcgctacta tttcaaggcg ctgtatttca gagaaccgaa cggcattttg ttcgagttat 1235101 caacagacgg accgggcttt atggtagatg aaaatcttga tgagcttggc caaacgattg 1235161 ctcttccgcc atatctagag catcgaagag cagaaattga agcaaaattg aaaccgatcc 1235221 aataaattgt gattcttttg ccttccggcg ccgccggagg gcttttttta ttaccataat 1235281 taattttgac ctaaacagca tgccttatta gggaggaaat atcagatgct gattgggaga 1235341 aatggcttaa aaccctttgc aaatatgggt gattggtatg gaatggcctc ggcaaaaata 1235401 ttgtctttgt ttattaatag tttattcata tttgcttgtt acactatttc aaagttagac 1235461 aaaaaggagt gaaaaataag tggaaaagaa aaaacgcgag ctggatatcg tcctcctcct 1235521 cattttgctc gcatctgcat tcttaaatat ctataacatt tggaaggacg acacggtgaa 1235581 tccttattac accgcggcag ttacaagtat gatgcaaagc tttcataatt tcttttatgc 1235641 ttcgttcgat gctgccggct ttataacagt agataaaccg cctgttacat accaaatcca 1235701 aacgatcagc gcactgatat tcggtatgca cggctggagc gtcatcctgc ctcaggcact 1235761 tgctggtgta ggttctgtcc ttcttatgta cttgctgata aagccgacat ttggaaaaac 1235821 ggcggcgcgt attgcctcat ttgttatggc atgtacgccg atagctgtag ctgtagcacg 1235881 tacaaacaat gttgatgcat tactggtatt tttcttattg cttgctacat ggcttctctt 1235941 taaagcgatc agaaaaggaa agctgatctg gctgttagca gcatttttcg ttgttggagt 1236001 aggttttaat acaaaaatgc tgcaggctta catgatttta ccggctttct tattgttcta 1236061 tctgattgcg gcaaacgcca caatcaagaa aaaaatcgtt tcattggtaa gtgcgttagc 1236121 cgtattagca gccgtttcgt tatcgtggcc gctcattgtt gacaatatcc ctgcaagcaa 1236181 gcggccttat atcggaagca gccaaaccaa ctctgttttg gaattggctt tcggctataa 1236241 cggaatccag cggctgacag gccaaaattc aggcggcggc cagggtgcgc caaacaaaga 1236301 cgcttcaaaa gaaatgtctt cttctgataa cactcaagca ccgcctaatc agtcatcaag 1236361 caacagctca tcaagcgatg gtaaatcctc aaatggcaat atggcggcgc ctccatccaa 1236421 tggccaaatg ccaagcggcg gtcaaggagg ccctccaagc ggcggagatg gcggccaagg 1236481 cggacccggc ggagacggag ggaaaggcgg tacaggaacc ggttcgaaaa tgcaatcagg 1236541 ttcagggatg tttggaacgg gaacacctgg tccactgcgg cttttccaac aagagttatc 1236601 tgatcaaatc agctggcttc tgccatttgc gatatttgga atcgcaggct tactgatcgc 1236661 tggcgcaaga gaaagaagaa gattatctgt agagcagaag gaaacggtgt tctgggttgc 1236721 gtggcttgta ccgattgccg gattcttcag tgtcgcagaa tttttccatc attattatct 1236781 catcatgctg gcaccgccga ttgcggctct tgtcggtgcg gggtgggtcg ctcttgttca 1236841 tctgtaccgc aatcagacag gctggaaagc atggcttttg ccgggagcaa ttattgcgac 1236901 aactggattt gaattgttta ttctcagaaa ctacaacgat caaatcggtg ttggatggag 1236961 tatcggggta ggtgttatcg gcgtgttgtc agcgattgct ttgctgctgt ttaaacagcg 1237021 ccaaaaaccg ttcagttatt atgtttcact tgcagctctc ctcgcattgc tggtgatgcc 1237081 gatgtattgg gcaagtacac cgcttctgta cggaggcaac agctcactgc ctgaaacagg 1237141 ccctcaactc gcatcaatga gcggaaaagg catgggaatg tctgatgcga ctgtaaatga 1237201 aaaactgatc aaatatctag aggagaataa ctccggagct gaatacctat tcgccacaac 1237261 cgattcgaac acagcggcac catatatcat taaaacgaaa aaagctgtca tggctattgg 1237321 tggatacagc ggttctgacc cggcaatcac actgactcaa ttcaaaaaac ttgtaaaaga 1237381 aggaaaagtg aaatacttct tggcttctgg aatgggaaga ggcggaaaca atgacattgt 1237441 tgaatgggtt gagaaaaatg gaaaagaagt agcatcagaa aaatggcaat caagttctga 1237501 tcaaaaaaca gaaaatactg attcagctga tacatcaagc agcaaggctt caggtgaaaa 1237561 cggcaaaatg ggcggacctg gcggaatgaa tcagtcagca acattatacg aactacatgc 1237621 tgatgaatag gaggcaaaaa catgagcaga catattcaat attcaattgt tgtacctgtg 1237681 tataatgaag agcttgtcat tcatgaaacc tatcagcgct taaaagaggt catggatcaa 1237741 acgaaggaaa actacgagct gctttttgtc aacgatggca gcaaagaccg cagtattgag 1237801 attttaagag agcacagcct gatcgatccg agagtgaaaa ttattgattt ttcaaggaat 1237861 tttggacatc agatcgccat tacggcaggt atggattatg cacaggggaa tgcaatcgtc 1237921 gtcattgacg ccgatttgca ggaccctcct gaactgattt tagaaatgat tgaaaagtgg 1237981 aaggaaggct atgaagtcgt gtacgccgta cggactaaac gaaaagggga aacctttttc 1238041 aaaaaacaaa ccgcggctat gttttaccgg cttctcagcg gtatgacaga tattgatatc 1238101 ccgattgata cgggggattt tcgcctcatg gacagaaaag tctgtgatga aatgaagaga 1238161 ttaaaagaaa aaaatccatt tgtaagaggg ctagtcagct gggtgggttt caaacagaca 1238221 gcggtcgagt atgtacgtga tgaaaggctc gccggagaaa caaagtaccc gctcaagaaa 1238281 atgctgaagc tgtcaatgga cggcatcacg acattttcac ataaaccgct gaagctggca 1238341 agctatgcgg ggattttaat gtcaggtact ggatttctgt atatgtttat cgtgctgtat 1238401 ctgaagctat tcacagacag cacgattacc ggctggtcat cacttattgt gatccagctc 1238461 ctgttcagcg gcattgtcct tctgattttg ggcgtgattg gcgaatatat cggcagaatc 1238521 tacgatgaag ccaaagacag gccgctttac atcgtccaaa aatcgtatgg aattgaaaat 1238581 aaaagactct atagagacca gcatatgtca taacctcaaa ccccctgtcc gtaatggaca 1238641 gggggttttt atgctctgag cacgatctaa agcaaaagat gctgatagat atatggaaat 1238701 tgggtaaaga agagattgtg agcttgtact gcggttcagt catgctgaaa taaaaacagc 1238761 aaaacttaaa gatttcgtcc tcggctttgc tgcatgtcag ctgttatatt ggggggcttt 1238821 taagaaacgc atgattagag ccgtaccagt tatgtttaat agaatactcg tacccaatac 1238881 aattccccac gtcaacgtcg attcagagag aagaaagctc agcaaaagaa aagccaatcc 1238941 tgcgcagatc atacccagtc ccacggtttt catgttcatg cctcctagca aacgatgttt 1239001 ctagcatctg atgtgaatga tgtcaatctg tatgatatac ggatatctcg tcagaaagtt 1239061 tcatagaaca attaggtctt ttatctaata aaaagcctca gaccgctttt acggcctgag 1239121 gcattatgtc ttacgaagtt ttctcttctt tttgatccag tttaattttt ttcgtcattt 1239181 ctttgccgtt tcggagaatt ttcacttcaa cggtatcacc gatctttgcg tctttatata 1239241 agatattgcg caattcactg cctgtatcaa tttctttacc ttttaggccg atgataatat 1239301 cctccgcttt taatccggcc ttttcagcag gagagcctga agcgacctca cggatgtaaa 1239361 cgcctttatt cagctggctg ccgaacaggc cgagtgtgcc ttcttggtaa ttttgcggca 1239421 cttgctctag atcaagcatg ctgacaccga tatatggacg ttcaatttgt cctttagaca 1239481 gcaattcttc agcaatcggt tttacgtcat tgcttggaat ggcgaatccg ataccctcaa 1239541 catcatcctc actgattttc atactgttaa tgccgacaat tttgccgtct gtatttaaca 1239601 aaggaccgcc gctgttacct ggattaattg ctgcgtctgt ctgaatgacg ttaatgctcg 1239661 tttcgccggc tgatgtagac attgaaaccg ttctgtccac gccgcttaca attccttgtg 1239721 ttactgtgcg ggacaggtct tttccaagcg gatccccaat cgcaataacg gtctcgcctg 1239781 ttctaagatc agatgaatca ccgaagtttg ccacttttgt gacgtggtca tcactgattt 1239841 ggaggacggc taaatcagtt aacgagtcac tgcctaccag ctttgcagta acctcagtgc 1239901 cgtcatataa agataccttc agtgatgatg ccccttctac gacgtggtta tttgtaatga 1239961 tataagcctt gccattctct tttttgaaaa tgacacctga ccctgaaccg ctttctgtat 1240021 cttcgctgga atcagaagaa ctagagccga acaaagagct gtttgattgt gcctgaagat 1240081 ttgtaatacc gacaatcgct ggtgaaaggt cttctaccat atctgagatt ttagaagagt 1240141 cctcgctctt gaatgcagat gagctgcttg agcttttttt agattcagag gaggtgcttg 1240201 ttgctgtaac agattgcgtt tgctgctggc tggatgattg ttttgcagtg tcctgagaat 1240261 catggtcacc aagcggtgta aacgtgtaaa tgccaagagc aagactgccg ccgatcactc 1240321 cgccaagcaa cggtctgaac catccgaatc ctcgtttttt cttctcctga tcatgaatga 1240381 cattgcgggc cgagtaggag gcgctctgat cgttctcttt cgttaaaaag acctcattct 1240441 cattaccttt cgttctgttt tcatcacgat agttatccat catgttcact ccgtttctct 1240501 attttcacat gtctatttat attgataggt ttatgacttg agtttatcat aaacaaaaac 1240561 tgtgggataa aaatgaaaag attatgggaa attgtgaaaa agtgcggaaa acggtacact 1240621 tcatattgta tatgaaagga ctgagtcgat ggaacagatt ggattgattg gatatggcag 1240681 catggcggat atgatcgcta gacagctgtt gaaacatgaa caaataaaag agaatgagct 1240741 atttattgag acgagaacga agggggagcg gctgcgggca ctcatgtcag attatccaaa 1240801 cgtatcggct gatccgttgg agaattgggc aaatacgtgc caattgattt tgatatgcgt 1240861 cccgccactc catgtcatcg aaacaatgcg ccgtctgtac ccgtatgtga acagaaatac 1240921 tcacatcgta tccatagctg ccggtgtgcc gctgcgtctt ttggaggcag aaacagaagc 1240981 cggtatctca cgtgttattc ctgccattac gtccgaagca gaagccggca tctcacttgt 1241041 cgttcacagt gaagcactgg ctgcagagaa aaaagaacgt ctgaatgaat tgttatcggt 1241101 tttcagccgt gtacgggaaa tcaaagaatc gaatttagat gtggccagca atttaacgag 1241161 ctcggcaccg ggattcatag ctgcaatctt tgaagaactg gcactgtctg ccgtcagaaa 1241221 cagcagcctg tccaaagaag aagcctttga ttttctgatt cattcgctat acggaactgg 1241281 caagatgctg atcgaaaaaa atatgtcttt cgaggagacg ctggaacgtg ttgcaaccaa 1241341 aggcggaata acgggagagg gagctgaggt gatacacgcc tctgtgccgg acgtttttga 1241401 tgaggtattt gaaagaaccc tgagaaaata tgaactgctt acagaacagg ttggtaaaca 1241461 aacatgaatc cttgaaagag gattcttttt ttatcactga atgattgaga tttttcccag 1241521 ttatattgca tttttcctct ttttttaata taatttgtta gaatattcat aatttagtaa 1241581 aaaaggagga gcgttatgaa attgtacatg tcagtagata tggaaggtat ttcgggtctt 1241641 ccggacgata cctttgtgga ttccggcaag cggaattatg aacgcggacg gcttatcatg 1241701 actgaagaag caaactactg tattgctgaa gcgtttaaca gcgggtgtac cgaggtgctg 1241761 gtcaatgaca gtcattcgaa gatgaataat ctgatggttg aaaagcttca ccctgaagca 1241821 gacttgattt ctggtgacgt caaaccattt tcaatggtgg agggactgga tgatacgttt 1241881 agaggcgctt tgtttctcgg ttatcatgcg agagcctcga ctcctggtgt catgtcacac 1241941 agcatgattt tcggcgtccg tcatttttac ataaacgatc ggcctgtcgg tgagcttgga 1242001 ttaaatgcat acgttgccgg ttattatgat gtcccggtat taatggtagc cggggatgac 1242061 cgggcggcga aggaagcaga agagcttatc ccgaacgtga cgacagccgc agtcaaacaa 1242121 accatttcaa gatccgcagt gaagtgcttg tcgcctgcga aagccggacg gctgttgaca 1242181 gaaaaaaccg catttgccct gcaaaacaag gacaaagtca agccgctcac accgcctgac 1242241 aggccagttc tgagcattga attcgccaat tatggccaag cagaatgggc gaatctgatg 1242301 ccgggaacgg aaatcaagac gggaactaca accgttcaat ttcaggcgaa ggacatgctt 1242361 gaagcctatc aggcgatgct tgtcatgact gagcttgcga tgcggacatc attctgctaa 1242421 aggggtgttt taggctttgg cgcgatacat gataaagcgt ttttgggcaa tggcagctac 1242481 gattttggtg attaccaccc tgacttttgt tctcatgaag gtcattcccg gatctccttt 1242541 taacgaggag agaggcacaa atgaagccgt tcaaaaaaat ctcgaagcct actatcactt 1242601 agacgatcct ctcattttcc aatacatttt ctacttaaaa tccatcatta cattcgattt 1242661 cggaccttca attaaaaaac cgtcggacag cgtaaatgat atgctggaac gcggatttcc 1242721 cgtttccttt gagcttggga tgacagcgat tgtcattgct gtgatttctg ggctggtgct 1242781 gggcgtaatc gctgcactcc gccgcaatgg ctttttggac tacgccgcga tgagtcttgc 1242841 agtactcggc atctccatcc cgaattttat tctggcaaca ttgctcattc agcaatttgc 1242901 tgtcaatctc aaactatttc ccgctgcgac atggacgagc ccgattcata tggtgcttcc 1242961 gaccgcagcg cttgctgtag ggccaatggc gatcattgcc aggctgacac ggtcgagcat 1243021 ggtcgaagtt ctgacacagg attatatccg cacagcaaaa gcaaaagggc tttctccgtt 1243081 caaaattatc gtaaaacacg cactcagaaa tgcactcatg cccgtcatta ccgtcctggg 1243141 cacactcgtc gccagcatct taacaggaag ctttgtcatt gaaaaaatct ttgccattcc 1243201 gggaatggga aaatattttg ttgaaagcat taatcagcgg gactaccccg tgattatggg 1243261 aacgaccgtt ttttacagcg tcattctgat tatcatgctg tttttggtcg atttggccta 1243321 cggtctctta gacccgcgca ttaaactgca taagaaaggg tgaagcgtgt gaatctccct 1243381 gtacaaacgg atgaacgcca gccagaacag cacaatcagg tgcctgatga gtggtttgtc 1243441 ttgaatcagg aaaaaaatcg ggaagccgat tcggtcaagc ggccgagttt gtcatacacg 1243501 caggatgcct ggaggaggct gaaaaaaaat aaattagcga tggccggact ctttattctt 1243561 ttatttcttt ttgtcatggc agttatcggg ccctttttat cgccccatag tgtcgtacgc 1243621 caatcgctga cagaacaaaa tcttccgccc tcagccgatc attggttcgg caccgatgaa 1243681 ctcggccggg atgtgtttac ccgaacatgg tatggcgcga gaatctcgtt gtttgtcggc 1243741 gtgatggcag cactgattga ttttttgatc ggtgtcattt acggaggcgt tgccggctat 1243801 aaaggcggca ggattgacag cattatgatg cggattatcg aagtgctgta cggactgccg 1243861 tatctgcttg ttgtcatttt gctgatggtg ctcatgggac cgggactggg cacgattatt 1243921 gtggcgctga ctgtgaccgg gtgggtcggc atggcgagaa ttgtaagagg ccaggtgctt 1243981 cagattaaaa attatgaata tgtactcgcc tcgaaaacct ttggcgcgaa aacctttcgc 1244041 atcatccgga agaatttgct gccgaatact atgggagcga tcatcgtaca aatgacatta 1244101 accgtacctg ccgccatatt cgcagaatca tttttaagct ttctcggcct gggcatacag 1244161 gctccgtttg caagttgggg cgtgatggcg aatgacggcc tgcctacgat tttatctggg 1244221 cattggtggc gcctgttttt tccggccttt ttcatatctc tgacgatgta cgcgtttaat 1244281 gtgctggggg acggattgca ggatgcgctt gaccctaagc tgaggaggta gctgtatgga 1244341 aaaagttctg tcagtccaaa atctgcacgt gtcttttacg acttacggcg ggacggttca 1244401 ggcggtcaga ggggtgagct ttgatttgta taaaggagaa acctttgcga tcgtcggcga 1244461 atccggctgc ggcaaaagcg ttacctccca aagcatcatg ggcctgcttc cgccttattc 1244521 ggcgaaggtg acagacggca ggattctatt taaaaacaaa gacctttgcc gtctctctga 1244581 caaagaaatg agaggtataa ggggagccga catttctatg atttttcaag acccgatgac 1244641 ggcgttaaac cctacgctga ctgtcggcga ccagctgggg gaagcgctat tgcgccacaa 1244701 aaaaatgagc aaaaaagcgg cacggaaaga ggtgctttcc atgctgtcat tggttggtat 1244761 tccagatccc ggagagcgcc taaagcaata tccccaccaa ttcagcggcg gtatgagaca 1244821 gcggattgtc attgcgatgg cgctgatttg cgagcctgat atcttaattg cggatgaacc 1244881 gaccaccgcc ctggatgtaa ccattcaggc acagatttta gagctgttta aagagattca 1244941 gagaaaaacg gatgtgtctg tcattctgat tacgcacgat ttaggggttg ttgcccaggt 1245001 agctgacaga gtcgcagtca tgtatgccgg gaaaatggcg gaaatcggca caagaaaaga 1245061 tattttttat cagccgcagc acccatatac aaaaggcctg ctgggctctg tcccgcggct 1245121 ggatttaaat ggcgctgagc tgaccccgat tgacggaacg ccgccggatt tattttcgcc 1245181 tccgccgggc tgcccgtttg ccgcccgctg tccgaacagg atggttgtgt gtgacagggt 1245241 gtacccgggc cagacgatca gatctgactc gcacaccgtc aactgctggc tgcaggatca 1245301 acgagcagag catgcggtgc tgtcaggaga tgcgaaggat tgaacatgaa aagggggaag 1245361 aggatgaaac gagtgaaaaa gctatggggc atgggtcttg cattaggact ttcgtttgcg 1245421 ctgatggggt gcacagcaaa tgaacaggcc ggaaaagaag gcagtcatga taaggcaaaa 1245481 accagcggag aaaaggtgct gtatgtaaat aatgaaaatg aaccgacttc attcgatccg 1245541 ccgatcggct ttaataatgt gtcatggcag ccgttaaata acatcatgga ggggctgacg 1245601 cgtcttggca aagatcatga gcccgagccg gcaatggcgg agaaatggtc tgtttcgaaa 1245661 gataataaaa cttacacatt tacgattcgg gaaaatgcga aatggacaaa cggagatcct 1245721 gtaacagccg gagacttcga atacgcgtgg aagcggatgc ttgatccgaa aaaaggcgct 1245781 tcatcggcat tcctaggtta ttttattgaa ggcggcgaag catataacag cgggaaaggg 1245841 aaaaaagacg atgtgaaggt gacggcaaag gatgatcgaa cccttgaagt tacactggaa 1245901 gcaccgcaaa aatatttcct gagcgttgtg tccaatcccg cgtatttccc ggtaaatgaa 1245961 aaggtcgata aagacaatcc aaagtggttt gctgagtcgg atacatttgt cggaaacggc 1246021 ccgtttaagc tgacggaatg gaagcatgat gacagcatca caatggagaa aagcgacacg 1246081 tattgggata aggatacagt gaagcttgat aaggtgaaat gggcgatggt cagtgacaga 1246141 aatacagatt accagatgtt tcaatcaggg gaacttgata ccgcttatgt ccctgctgag 1246201 ctgagtgatc agctgcttga tcaggataac gtcaatattg ttgaccaggc gggtctctat 1246261 ttctatcgat ttaatgtcaa catggagccg ttccaaaatg aaaacatcag aaaagccttt 1246321 gcgatggctg tggatcaaga ggaaattgta aagtacgtca cgaaaaataa tgaaaaaccg 1246381 gcgcacgcct ttgtatcgcc tgggtttacg cagcctgacg gcaaagattt ccgtgaagca 1246441 ggcggagacc tgatcaagcc taacgaaagc aaagcgaagc agctgctcga aaagggcatg 1246501 aaggaagaaa actataataa gcttcctgcg atcacgctta cttacagcac aaagccggag 1246561 cataaaaaga ttgccgaagc tattcagcaa aaattgaaaa atagccttgg agtcgatgtg 1246621 aagctggcca atatggaatg gaacgtattt ttagaggatc aaaaagcgct gaaattccaa 1246681 ttctctcaaa gctcattttt gcctgattat gcagacccta tcagttttct ggaagccttt 1246741 caaacgggaa attcgatgaa ccgcacaggc tgggccaata aagaatacga tcagctgatc 1246801 aaacaggcga aaaacgaagc cgatgaaaaa acacggttct ctcttatgca tcaagctgaa 1246861 gagctgctca tcaatgaagc gccgatcatt ccggtttatt tttataatca ggttcacctg 1246921 caaaatgaac aagtaaaagg aattgtccgt caccctgtcg gctatatcga tttaaaatgg 1246981 gcagataaaa actgatggag gcgattgagg aaatactgct tctttatgcg aaggagcggt 1247041 attttttctc tttcttgcac gtatacgtag ggtgcagagc aaatgaaagg agtgttttcg 1247101 ttgaattaca agccgaaagc gttgaacaag ggtgatacag tcggagtgat cgcgcccgca 1247161 agtccgccgg atccaaaaaa gcttgacacc gcgcttttat ttttagaaga gctcggtctt 1247221 caggtgaagt tgggcaaggc gctgaaaaac cagcacggct atttagcggg acaggatgat 1247281 gagcggctgg cggatctcca tgagatgttc agagacgatg aggtaaaagc agtgttgtgc 1247341 gcatgcgggg gttttgggac aggacgtatc gccgcgggca ttgatttcag cttgatccgc 1247401 aaacacccta aaatcttttg gggatacagc gatattacgt ttttacatac tgccattcat 1247461 caaaacacag gtcttgtcac tttccatggc ccgatgctca gcacggatat tggccttgac 1247521 gacgttcacc cgctgacaaa agcgtcatat aagcagctct tccaggagac ggaattcacc 1247581 tatacagaag agctttctcc gctgaccgag cttgttcctg gaaaagcgga aggcgagctt 1247641 gtcgggggaa atctgtcttt gctgacgtct acactgggca cgccatttga aattgatacg 1247701 agaggaaagc ttctgtttat tgaagatatt gacgaggagc cttatcaaat cgaccggatg 1247761 ctgaatcagc tgaaaatggg ggggaagctg acggacgcgg cgggaattct agtttgtgat 1247821 tttcacaatt gtgtcccggt gaagcgagag aagtctctct cgcttgagca ggtgctggaa 1247881 gactatatta tttctgcggg caggcctgct ctgagaggat ttaaaatcgg ccactgctcg 1247941 ccaagtattg ccgttccgat cggtgcgaaa gctgctatga atacagcaga aaaaacagcc 1248001 gtaatagagg cgggcgtttc agaaggggcg ctgaagacat gaaaatcatt cgaatcgaaa 1248061 caagccgaat cgctgtcccg ctgacaaagc cgtttaaaac cgcacttcgc actgtgtata 1248121 cggctgaatc agtcatagta aggattactt atgacagcgg tgcagtcgga tggggagaag 1248181 cacccccgac gttagtgatt acaggagaca gcatggatag cattgaaagt gccatccacc 1248241 atgtgttgaa gccggcattg cttggaaaaa gcctggcggg ctatgaggcc attctgcacg 1248301 acatccagca tcttcttaca ggaaatatga gcgcgaaggc tgctgtagaa atggctctat 1248361 acgacggctg ggcgcagatg tgcgggctgc cgctttatca aatgcttggc ggatatcgag 1248421 atacgctgga aacagattat actgtcagtg tcaactcacc tgaagagatg gcagctgatg 1248481 ccgagaatta tctcaaacaa ggctttcaaa cgctgaaaat aaaggtcgga aaagatgata 1248541 ttgcaacaga tatcgcccgt atccaggaaa tcagaaaacg tgtcggatca gctgtgaaac 1248601 tgcgtttaga cgctaatcag gggtggaggc cgaaggaagc ggtaactgcc attcggaaaa 1248661 tggaggatgc gggcctaggc attgagcttg tcgagcagcc tgtccataaa gatgatctcg 1248721 ctgggcttaa aaaggtgaca gatgcaacag atacgccgat tatggctgat gaaagtgttt 1248781 ttacaccgcg ccaggcgttc gaagttctgc aaacccggag cgcagacttg atcaatatta 1248841 aattgatgaa agcgggcggc atcagcggag cagagaaaat taatgccatg gcggaggcct 1248901 gcggggtgga gtgtatggtc ggcagcatga tcgaaacgaa gctgggcatt acggccgcgg 1248961 cgcattttgc ggcaagcaag agaaacatca cacgctttga ttttgacgcg ccgctgatgc 1249021 tgaaaacaga tgtattcaat ggcggcataa catatagcgg cagcacgatt tcgatgcctg 1249081 gcaaaccggg cctcggaatc atcggggctg cgcttttgaa aggggaaaaa gagcaatgat 1249141 gcacactgtc atatcagcag tggccaacat ctggacagcg cctgattcac ctcgtccgtc 1249201 tgatcaattc atgcttcaac cgactgtaat gatcagagac tggctggagc gcatgacgta 1249261 tgatgaacgg cttggattat gtacagacaa tgtaatccaa actcaggttc tctttggcga 1249321 aaaggtactt gtgacggcgg aacaggggga atgggtttct gtgatcgtgc ctagccagcc 1249381 atcccgaaag gatccgcgcg gatacccggg ctggatgaaa aagtaccagc tggaaaaaac 1249441 aaagcccatc catacacaac acgatgtgat gatcagcaaa cctgctgcct ttttgtacag 1249501 aagcaatggg gaaaaggaga tcgaattaag ctttttgaca gttctgcccc ttattgcaaa 1249561 agaaaacgga tattttaagg tttcgaccgt ttttggggaa aggtttgtga ggcaaagtga 1249621 tgcagtgcct gtcagccaac agaaagggac tgctgaagac atcattcaaa cgggtgcgtt 1249681 ttttcttggc cttccctacc tgtggggagg gatcagcggg tttgggtttg attgctccgg 1249741 atttatgtac agtatattta aggcgaatgg atacagcatc ccccgtgatg cgggagatca 1249801 ggctaaggca gggaagggtg tcccgcttga tgatatgaaa gccggtgatc tgctgttttt 1249861 tgcttatgag gaaggaaaag gagcgattca tcacgtcggt ctgtatgtag gcggcgggaa 1249921 aatgcttcat tctccaaaga cagggaagtc aatcgaaatc ctcacattaa cagagacaat 1249981 ctatgaaaaa gaattatgtg cggtgcgccg ctgtttttca gaataaggag ggagacaaat 1250041 gaggcgactg cctttgttag aggtcagcca gctgaaaatg cattttgacg cagggaaaaa 1250101 gcggacagtc aaagctgtcg acggggtcac ctttcagatt cgtgaaggag aaacgttcgg 1250161 gctagtcggg gaatcagggt gcgggaaatc aaccttgggg agagtgctga tgcgccttta 1250221 tcagccgaca gaaggaagcg tgacataccg cggcacaaat cttcatgcac taagtgaaaa 1250281 agagcagttt gccttcaacc gcaaactgca gatgattttt caggaccctt atgcttcact 1250341 taacccgcgc atgaccgttc gagaaattat tttggagccg atggagattc ataatctcta 1250401 caatacccat aaagcacggc ttctcgtcgt ggacgagctg cttgaggcag ttgggcttca 1250461 ccccgatttt ggcagccgtt atccgcatga attcagcggc gggcaaaggc agagaatcgg 1250521 gattgcgaga gcactgtcgc tgaatcctga atttatcgtg gcggacgaac cgatttctgc 1250581 acttgatgtc tctgttcaag cgcaggtggt caacctgctg aagcggcttc aaaaagagaa 1250641 agggcttacg tttttattca ttgcccatga tctttcgatg gtgaagcata tcagtgacag 1250701 gatcggtgtt atgtacttag gacacatgat ggaaattaca gagagcggca ccttgtatcg 1250761 tgaaccgctc catccctata caaaggcgct tttgtcctcg attccgattc cagatcctga 1250821 attggaggac aagcgtgagc gtattctctt gaaaggggag ctgccgagcc cggtcaatcc 1250881 gccaagcggc tgcgtgtttc gtacccgctg tccggaggcg atgcctgaat gtggagaatc 1250941 tcgtccccag cttcaagaaa tcgaacccgg ccgttttgtc gcttgccatt tgtatcgaaa 1251001 tgctgaaacg aaggaaaaag taagataaat aaaaagagtg gctccttttt actagagcca 1251061 ctccatttgt ttatacttga tgtaaaaact ttacacaaac cgggtaaggg acagaaaccg 1251121 ttgatgggag gagtgtcaat cggccggttt ctttgtctct ttcaaacaag acaaggttgc 1251181 ctgtttcttc atttgaagca acgaggaacc cttccgttgg gtcaaataca aagtcacgag 1251241 gccagtttcc ttctgtcgac actctttcta cgaaagccag ctctcctgaa tattgattca 1251301 cttcaaatac ggcgatactg tcatggccgc ggtttgcgac ataaacaaaa cgtccgtcct 1251361 gcgtgacatg tattgcgctt ccctggctgt tatctgtaaa atcatcaggg atggcagaaa 1251421 cgacttggat ttctctaaat tcgccggctg tcgggttgta ttcaagcgca atcacttcat 1251481 tgcttaattc tgtcatgaca taagcgtatt tttctttcgg atgaaaagcg atatggcgag 1251541 gtcctgcacc gggagcgaag gaatggcttc cggattcagt caacacaccg tctttaagct 1251601 tataggtgta gagcttatct atacctaaat caaccgctac cacataattg tgttcaggtg 1251661 tgaaccccgc gtagtgtgta tgcggttttt cttgtctttc gtgcggccct tttcctgtgt 1251721 gagcggcctc tgaaacaggt gattgcaagc tgccgtcttc ctgaaccgga aaaacgtgta 1251781 ccttcccgct gtgataattg gcagtcagta cgaattgatt ttgatcatca acgcttacgt 1251841 ggcatggcga agggccatca attaactgat gattcagaaa tgtcaattcg ccgctgtttt 1251901 tatcgatttg ataggcagca actccgcctt ggccgtctgc tttttcgatg gaataaagga 1251961 tggtgttgtt tttattcgtc gccacatatg tcgggttgcc cagcttagcg gccagctttg 1252021 gctcgctgag tgcttttttc tcagtatcaa gctcaaatga ataaattcct tcgcttccgc 1252081 cttttgtata tgttcccaca tatcctatgt attttgtcat gcgatttccc ccttaaaaat 1252141 gatgtcacct ctatattaac gtatcttgat aaaataagct gttcaaaaca tgaaaaaggg 1252201 gaagattctt cattcgcctc gaatcagcgg cattgtgcag cacctgaagg agccgcctga 1252261 tttaataatt tctgacaggt caatttcgat aatgtgatag cctcttttcg atagctgttg 1252321 attgacatgg cggttgccag ggagactgat gatcgttttt tttccgattg aaaggacgtt 1252381 ggtgccaagc gtaaattgtt cgtcctcggg cacctcaata agatcataac gttttgccag 1252441 catatcggct gcatctggct caatggcctg tgaataaatt aacgcttcgc tttcagatat 1252501 aatgttaaat acgcagtcca aatgcaaaaa tttttcatga agcttcactg gaacgatcgt 1252561 atattcagga agtgcctctt ctagctggcc gatagctgaa atgtcggtgc gctggctgat 1252621 tccgacatag acaatgtcat catcgataat gacgtctccg ccttcaatac tcgtatcaag 1252681 catgcgggtg taagagatac cttggctgtg aaaaaaatct tttataacgg cttcttctcc 1252741 ttggcgaatc ggttcagtca tgcttgacag aaaggctttt tctccgatga caaatcctat 1252801 gtccctagta aaaacctgtt ctgggagtcc gtcgcgaacg ggcaaaagga cgacctcaac 1252861 gttgtgtgac ctaagtgcct ccactaagcg gctgtgctgg tcgttagcgg tttttacatg 1252921 aatattgtca tcttcaaaat gtttttgtgt ttcgtttata acatctttta tggtcatgtg 1252981 ctcaggtttg cataagatca ctttttgaag tgtgccgtat tccgttcggc ataccgtttt 1253041 gtgctgagat ttcgggatgg atacgtccat ttgtttttcc tcctaaagtg tgaagaatac 1253101 atttattatt ccctcatcat gaaaatcatt aaaccatttt aaattttaga caaatggaag 1253161 agaatattgt ttaataggag aatataagtg catttagcta aaagatcaga catcaaaggg 1253221 gagaaaggta tggaaacacc ggaaacaaga ttttgtaaag agtcaaaggt tgtgaaaacc 1253281 agcagggtgt tcccgcttga cacgaacaac cataatacgc tgtttggcgg aaaattaatg 1253341 agctacatag acgacattgc ctctatttca gcggcgcgcc attgcagacg tgaaacggta 1253401 acagcttcaa tggattctgt agatttttta aagccgatcg ggcaaaagga ttctgtctgc 1253461 ctagagtcat atgtgacatg ggtcggcaca tcttccatgg aagtatttgt gaaagttatt 1253521 aaggagcatt tgatgactgg cgaacgggaa ctcgctgcca catccttttt gacatttgtc 1253581 gcattagatt caaatggcaa gccggtgcct gtaccgaggg ttgtaccgga aacagaagaa 1253641 gaaatcatgc tgcataatac agctgtacag cgtgctaatg aacgtaagaa ccgcaagaga 1253701 cacagccagg cgcttgcaaa tgcgctcgga actgataagc cttggtgaac gttaaaccca 1253761 aaacataagt tgttttgggt ttttttgtac ttttcaatgg tgattattac aatggttagt 1253821 ccgtttttgc taggggattc tataaaaaag caacaaatgt catgttaaat tgataatttt 1253881 gtgacaactt tattaaagat tcattttaga tatatctttt attcgtaaga tcatgtattt 1253941 taaagatata ttttaaatac atcttttcga aaggattgtt tataaaatgt tagataacaa 1254001 aacaatcgaa attattaaaa gcactgtacc cgtattgcaa cagcatggag aaacaatcac 1254061 tggccgtttt tacgatcgga tgtttcaaga ccatccagag cttttgaaca tttttaatca 1254121 aacaaaccaa aagaaaaaaa cacagcgaac tgcactggca aatgccgtta ttgcagctgc 1254181 ggcaaacatt gaccaattag gaaacatcat tccggttgtc aaacaaatcg gccacaagca 1254241 ccgcagtatc ggaattaagc ctgagcacta cccaatcgtc ggtaaatatt tgctgattgc 1254301 gattaaagat gtattgggag acgctgcaac tcctgacatt atgcaggcat gggaaaaagc 1254361 gtacggagtc attgctgacg cgttcatcgg aattgaaaaa gacatgtatg aacaggctga 1254421 agagcaagcc ggcggctgga aggagtataa gccattcgtt atcgcaaaaa aagagcggga 1254481 aagcaaagaa attacatcct tctatttgaa accggaagac agcaagccgt tacctgaatt 1254541 ccaagcaggg caatatatca gcatcaaagt gcggattcct gattctgaat atacgcatat 1254601 ccgccagtac agcctgtctg atatgccggg aaaagactat tatcgaattt cagtgaagaa 1254661 agatggtgtc gtgtcttcct acttacacga tgggctgcag gagggagatt caatagagat 1254721 cagcgcaccg gcaggggact ttgttttaga tcatgcatca caaaaagatc tcgttttgat 1254781 cagtgccgga gttggcatta caccaatgat cagcatgctg aaaacatctg tttccaaaca 1254841 gcctgaacgg caaattctgt tcattcatgc ggcgaaaaac agtgaatatc atgcattgcg 1254901 ccatgaagta gaagaagcag caaaacattc tgctgttaaa acagcatttg tgtatcgcga 1254961 gccgacagag gaagaccgtg caggtgatct gcattttcat gaaggacaga ttgatcagca 1255021 attcctcaaa gaactgattg ccaacacaga tgcggattac tatatttgcg gttcaccgtc 1255081 gtttattacg gcaatgcata agcttgtatc agagctcgga tcagcgccgg agtctatcca 1255141 ttacgagcta ttcggcccgc aattaagttt ggcgcagtcc gtttgaacac atacatgaaa 1255201 ctcttctcct ttcagagaag agttttttat tgagatataa gaaggcagac aagcgccggt 1255261 ttctacatcc ggacaatcac agacccgctg ccatttgtgc atacacggtt ttgctgttct 1255321 tgcattgttc tcagcaattc attgtttacc tcaatcgctc taattagttg cttcattctt 1255381 agctccaaac cggccagcct gtcgattgtt tgctgctggt agccctcggg ttggggagcc 1255441 aatggcagat caaagggcca aagggtattc gacttctgat ttttcatatt gcgtattgcg 1255501 cctccaatcg gtgtcacttt ctattatgtt atgttcaggc gatatgcacg ttcgcctaga 1255561 cactgatgca tagagggcct gccacggggc acaataggct caatatgacc agcggatgga 1255621 ggtaaagatc ggtgttatgg atggtatggg tatttttact gaagccagtt atcgtatttt 1255681 cgattgcata tattttgttt cggcttgccg gtaaaaaagc tgtgtcacaa atgaacaatt 1255741 ttgacctgct tttgaccttc gcaatcggaa ccattatcag tgagccgatc cttacatcca 1255801 agctgccgat gtcaatttat tatgcgggtg cttttttggt gctttatctt atcatgagca 1255861 agctctcttt atctaataaa tggcgatggc tcctagtcgt gagcccgact gtcctaatcc 1255921 gaaacgggga tattgatgaa cgcggccttc gtaaagaaag gctgactgtt aatgagctgc 1255981 tcggaaagct gagggaaaag ggctatgccg acccggctga cattgatctt gctatcattg 1256041 aagaaacggg agaagtaagc gtcatcccga aagaggaagc gagagcggtg caggtgcggg 1256101 atttgaatat ggaagctgaa cggaatttta tcccgattcc gctcatactg gatggcgaaa 1256161 tccttgatca taatttgaaa tatctccaaa aaaaccgatc ctggctgttt gagaagcttg 1256221 aggaaaaagg gtacagcccc aaactgctgt cttcgattat ccttggcacg atgaatgcac 1256281 gcggtgatat atcccttgat ttaaataccg ctaatgaacc gcagcatgat ccttacttat 1256341 ataaaccggg aaataacaat taagatggct ctctcttgta atgagagctt ttttcttttt 1256401 taaagggaat ttttgtttgg tgtcaaatgt acctagttag gaggggaact gaacatgaag 1256461 gacttatcca taagaaacga catggcgcca acggtcagtt tgctgtattc cgcagtggaa 1256521 gaaaacagtc tccgtctggc ttccatcgta agccatatga cacacagtga actttactat 1256581 aaggggcgct gccaaacaaa aaacagcacg gctcagcttt tgcaccatat cacaaatgtt 1256641 gatatcagat gggtctggcg tatcaaggaa aatcggatcc cggaccatat tgaacaggca 1256701 tacggcccga tgacagatga aagcggacgg ctgcctgaac cggtgaatca gccagactta 1256761 gatgaactcc tgaaaagaca tcagcatgta gtagagaagc tgaaatcggt atgcttcact 1256821 ttaactgaaa atgctttgaa ccagccgctt tccttcgaag gtgacaccgc gacgatacga 1256881 tggggaattt ggcatatggc agatcataac cgctatcatc aggcacatat tgaagctctc 1256941 aaaaaagaat ggaagcagga tgtggcgaag tatgaacgct aaaacgaagc ttgtgactga 1257001 tcgaattcgt ttgcgctgta tggaagatcg ggatcaagcc actttgtttg ggctgctttt 1257061 taatgatcct gacgtcatga catattattc cggtttaaaa gataagaggc aaacccgcga 1257121 gtgggtcaat tggaaccaac gaaatgaaaa agggtacggc gttagtctgt ggatcgccga 1257181 agataagcgg acaggggagt ttttggggca atgcggcatc gttccccagc agatcgaaaa 1257241 tcaaaccgta atggaaattg gctatatgtt tgcccgccgc cactggggga acggctatgc 1257301 gcaagaagcg gctcgggcct gtctggacta tggctttaac gagcggcagt tcggcaaaat 1257361 ggcggctttg attgatccgg gtaacaaagc gtccatacgg gtagcggaga aaatcggcat 1257421 gcattacagc aaaacgatca gaaaatggaa taaaccgatc gcggtatatg aaagaaaatc 1257481 ttacaattga aagatagagc tgagtttagt atcatgatat catgtaaagt tttctagggt 1257541 tccgcatgtc aattgacatg gactggtccg agagaaaaca catacgcgta aatagaagcg 1257601 cgtatgcaca cggagggaaa aaagcccggg agagtcaatc tcatgtgaga cgactgtccg 1257661 gggttttttt gttttcggag aatcttaata gatagaaagg aatgactcaa aatgaaatgg 1257721 ggattggtcg tgcttgccgc tgttttcgag gttgtttggg tgataggctt aaagcacgct 1257781 gactcagcct taacatggag cggcactgcc atcggcatca tattcagctt ttaccttcta 1257841 atgaaggcga ctcacagtct gcctgttggt accgtgtatg ccgtctttac cgggctcggc 1257901 acagcgggaa cagtacttag tgaaatcgtt ctttttcatg aaccggttgg atggccgaag 1257961 ctattgttaa ttggcgtgct cttaatcggt gtaatcgggt tgaagcttgt gacacaggat 1258021 gagacagagg aaaaaggagg cgaggcataa tgctgcactg gatcagttta ttgtgcgcgg 1258081 gctgtttaga aatggccggc gtggccctta tgaatcaata tgcgaaagaa aaaagcgtga 1258141 aatgggtgct gttgatcatt gttggttttg ccgcttcatt ttccttgctg tcgtacgcaa 1258201 tggaaaccac tccgatggga acggcttacg cggtctggac aggaattggc accgccggcg 1258261 gggcgcttat cggcatcctc ttttacaagg agcagaaaga cgccaaacgg atcttcttta 1258321 tcgcgttgat tttatgctca gcagttggtt taaaaattct gtcataaatt gatttttatc 1258381 aaatcttcag tataatggat aaatagttta gacttacaaa gataagaggg attattcatg 1258441 aaatcatata tgactcagcg gttggacgaa taccgtgacg gaaatgagga taaaggtcgg 1258501 ctcttggtca gctgccccga tcagccgggt atcgtctctg cagtttccgc gtttttattt 1258561 gaacacggtg ccaatattat agaatcaaat caatatacga cagaccctga aggcggccgg 1258621 ttcttcctga gaatcgaatt cgactgcgca ggcattcgtg aaaaaaaatc atcacttcag 1258681 gcagcgtttg cctctgttgc ggaaaaattc gacatgacat ggagcttaac tttggcgagc 1258741 gaactgaagc gtgtcgccat tttcgtttca aaggagctcc actgcctgca tgagctgatt 1258801 tgggaatggc aaaccggcaa cctgatggcg gagatcgctg ttgtcatcag taaccatgag 1258861 gaagcgagag agctggttga gcgcctgaac attccattcc actatatgaa agcgaacaaa 1258921 gacatcagag cggaagtcga aaagaagcag cttgaactgc tggagcagta cgatgttgat 1258981 gtgatcgtgc tcgcacgcta tatgcagatt ctaactcctg attttgtttc ggctcatccg 1259041 aatcgcatca tcaatatcca ccattcattc ctgccagctt ttatcggtgc gaatccgtac 1259101 aaacgggcct acgagcgcgg cgtgaaactg atcggtgcga catctcatta tgtgacaaac 1259161 gatcttgatg aagggccgat cattgaacag gatattgagc gtgtggacca ccgcgataat 1259221 gcggaagcgc tgaaaaacat cggaagaaca attgagcgca gcgtgcttgc ccgtgctgtg 1259281 aaatggcatt tggaagaccg tgtcatcgtt catgaaaata aaacaatcgt ctttaactag 1259341 actgcaagag gcccgcgcaa tgcgggctat ttttgatgac aaaaaacctt gacaagtgtc 1259401 ttttttcttt gcataatata aaaaaatcat tgagcgttga agaggattag taagcagacc 1259461 tttctgtgac agagagcaaa atgaatcgct gaaacatttt gccgcatgaa acctgccgaa 1259521 cctgccttgg agtcctaggg ggaaaaccta ggcgcataac ctggcgttac aggagagcgg 1259581 agcgtgcaca agcgcgttca atcaaggtgg taccacggaa acccatttcg tccttatgaa 1259641 tcaggatgaa atgggttttt ttattgtaga agagccgcgg aggagaataa atgaaaaaac 1259701 aaagaatagt agtgaaaata ggaagcagtt cgctcacgaa tagcaaagga agcattgatg 1259761 aggcaaaaat cagagagcat gttcaggcga tttccgtgtt aaaaaaagcg gggcatgaaa 1259821 tgattctgat tacctcgggt gccgtagcgg cggggttttc cagcctcggt tatccatccc 1259881 gtcccgttac catcaaagga aaacaggcgg cggccgcggt cggacaaaca ctgttaatgc 1259941 agcaatatat gaatcaattt aaacaatact cactgactcc gggacaaatc cttttaacga 1260001 gaaatgattt ttcgaaaaga gaacggtatc gaaacgcgta tgctacgata atggaattat 1260061 tagagcgggg cgtcattccg attatcaacg agaacgattc tacatctgtt gaagaattga 1260121 cattcggaga taatgatatg ctttctgcgt tagtcagcgg attgattcac gcggaccagc 1260181 tcatgattct cactgacatt aacggactgt atgatgccaa tccaaatgaa aatcctgagg 1260241 cgaaacgatt tgattatttg ccagagatca cgcctgaatt gcttggatat gcaggttcag 1260301 ctggatcaaa ggtcggcacc ggcggaatga aatcaaagct gttagccaca caaaccgcgc 1260361 tgtctctggg agtgaaagta ttcattggaa ctggcagcgg agagcaaaaa cttgcggaca 1260421 ttttggacgg caggggagac ggcacttata tcggagacaa agaactatct tcggttaaca 1260481 acacaaggca gtggattcag ttccactcgc cgatatcggg agaaattatc attgatgcgg 1260541 gtgccgaaga ggcgatgatc cataatggaa gcagcctttt gcccgctgga gttgtgggcg 1260601 tgaacggaag ctttccgaaa ggggcggttg tggaagtcag gggaccgggc ggcgtgatcg 1260661 gcaaaggcca aactcattac tcctccgagg agattatgga ggctaaaggc aaacgcagtg 1260721 acgaacttga ttttgagaaa acgtttgagg ttattcatag gaatgactgg gtcaatgtaa 1260781 aagactagga ggcggaaaaa tgagtgaagt ttctgtaaaa gcgaagctgg cgaaagaagc 1260841 agcagccgaa atgatcatga aaacaacagc cgagaaggat gaggcgctca gcctcattgc 1260901 aaacggactc cgcaaagaac tggattttct cttggcggag aatgcaaaag acattgtgaa 1260961 cggaaaagag aatggtttaa caccggacat cattgaccgt ctctcattgg atgagaaacg 1261021 gatacgcgat atcgcggacg cggtggagct cttaatcgac ttagcggacc caatcggcga 1261081 ctctcttgaa acgattgaaa aagaaaacgg cctgtttatt gaaaaaatcc gtgtgccgct 1261141 cggtgtcgta ggaatgattt atgaggcgag gccaaacgtc acagttgatg cggctaccct 1261201 ttgcctgaag acagggaacg cggttgtgct gcggggaagc tcctcagcca tccacagcaa 1261261 caaagcgctc gtcagtgtca tttacagagc acttgagcaa tcagcgcttc cgattcacgc 1261321 tgtgcagctg attgaggata cgagcagaga gacagcaaaa gagctcttta cgttaaatga 1261381 tggcttagac gtattgattc cgcgcggagg caagaaactg attgatctcg ttgtgagaga 1261441 atcaacagtt cctgtattag aaacgggagc aggaaactgc cacatattca ttgacgaaac 1261501 agccaaaccg caaatggcag aaaaggttgt tgtaaatgcc aaaacgcagc gcccttctgt 1261561 atgcaacgcg attgaatcat tgctgattca caaggcttgg gcaagacagc acggaaaaga 1261621 attgctggac cagctggaaa acgcgggagt tgaaattcgc ggtgatgaat tggtatgtga 1261681 acttcatcct tcaagcaaac aagcatcaaa agaagattgg gaaaccgaat ttttagcgcc 1261741 tgtcctcagc gtaaagacgg ttgaaaacgt ccaagaagct gtaaagcata tccaacaata 1261801 cggcaccaat cattctgaag cgattttaac tgaaaatgac aaaaatgcgg tatattttca 1261861 aacggctgtc gatgctgccg ctgtctatca taacgcgtca acccgcttta ccgacggctt 1261921 tgaattcggc tacggagccg aaatcggcat cagcacgcaa aagcttcatg caagaggacc 1261981 gatggggctt cctgcactga cttctacaaa atacatcatt aaaggaactg ggcaaatccg 1262041 tgaatagcgg ggtaatgttc aatgaaaaag cttatctcat tacgagataa gcttttttat 1262101 acgcgaaaaa ttgacatttc aaatttaatt gtgtacaatt taattgtata aaatatattg 1262161 ggggaatgaa aaatgagtca gccattattt accgcaactg tttcagcggt aggaggaaga 1262221 gaaggaaagg tcatttcatc agaccgcgtt cttgagcttg atgtcgcaat gccggggaca 1262281 ccgagagcca agaaattaga aaaagcgaca aatccagagc agctgtttgc agcaggttat 1262341 gcagcttgct ttgacagcgc cctgcagctt gtcgcaagaa cagaacgggt aaaagtagag 1262401 acagaggtta cagcaaatgt tagcctgtta aaggatgaag cggaccaggg ctataagctg 1262461 ggtgtgacgc tgcaagtaaa aggagaagga gtcagtgcat cagaattgga ggcgcttgtg 1262521 aaaaaagcgc acggcgtctg cccgtactca aaagcaacct ccggaaatat tgatgtgaca 1262581 cttgaagttg ctgaataaat aaaaagagga tgcctgtaca aggcatcctc aatttttttg 1262641 atgaagtgtt tccagtaatg tatatagagc ggactttaac tgtttgagat cctccccaga 1262701 ctgctttgag agccccagaa ttgtccctgg aatgtcaacc gctttttctt ttaataacgc 1262761 tccgtcctct gtcaggctga tcaacacgga ccgctcatcc tcttcagatc tttttctcgt 1262821 aatcaaaccc tgttgttcca ttcgtttaag catcggagtg agcgttcctg aatctaaata 1262881 cagctgttcg cccatttttt tgacagtaag cgtttcatgt tcccataaca aaagcaaagc 1262941 caaatattga gggtatgtta tattcagctt atcaagcagc ggcttgtatt gctttgtcat 1263001 ctcccgcgaa ctcgcatata gcaaaaaaca aagctgattc tccaatttca tatgatcaaa 1263061 tttattttcc attttgttca ccaactcttt tttgtcattc gattctattg tatctgaaaa 1263121 acctcacttt tcctattctc ggcaaacata gcatgtttaa aaagatcaga aagggaaata 1263181 taacaactag atacaaataa ggaggttggg aaatatggca ctatttacag caaaagtaac 1263241 cgcgcgaggc ggacgagcag gacatattac atcagatgac ggtgttcttg attttgatat 1263301 tgtcatgcca aatgccaaaa aagaaggaca aaccggcaca aatccggaac agctctttgc 1263361 ggcagggtat gctgcatgct tcggcggcgc gctcgaacac gtagccaaag agcagaatat 1263421 cgaaattgat tcggagattg aagggcaggt cagcctcatg aaggatgaga gcgacggcgg 1263481 gtttaaaatc ggtgtcacac ttgttgtgaa cacgaaagat ttagatcggg aaaaggcaca 1263541 agagcttgtc aacgccgctc atgaattctg tccttactca aaggcaacca gaggaaatgt 1263601 tgatgtaaaa ctagaattaa aataatgacc ggcatcctga ggattctcag gatgtttttt 1263661 ggtgtcggac atgcggggcg ggcacagatt tatgataaaa cttcagagaa gcgtttgaag 1263721 catgccttta aaccaaaagt tacagatgaa gcgggtggct ggcacggtgt ctgccgtgct 1263781 gaattgcgcg tatatgctgt tttgtatttg cacagggcat agcggctact tggagaaata 1263841 acaaggacca ggccgcgcat gcctgatcct tttaatattc tttcttattg gcgaagttcc 1263901 gccatgcttg aaacggggat aaatgctctg ttagtgtcac ttgataaaag gggatcgttc 1263961 tttcttcagc aggtttatca atttctttat aaatgaatga atcatcaaac ccggcttcgg 1264021 cagcgtctgt gtgctcagct gcatagaaaa cggctttagg ccgggcccag tagatggcgc 1264081 ccaagcacat tgggcatggt tcacagctcg tatacaaaat gcagtcatca agctggtagg 1264141 ctcctagcac cttacaggct ttccgaatag ctgtgacttc cgcgtgggca gtcggatcat 1264201 tgcttgttgt gacgttgttc tgtccctctg caataatggc tccgtctttc acgataacgg 1264261 ctccaaaagg cccgccgatt cctgcattca ctccttcaca tgcgagagtg acagcccgtt 1264321 ttaagaacgt ttcatgattc atcccaatcc ctcctgtcaa tagagtgtta ttagtatagc 1264381 cgaaaagaat gcaaagaaca ttcttaaaaa agtgcaaaat aaacaaagta tttgggggat 1264441 ttgctaaata agaaaccgat tgtggctgta ttatagaaaa aaaccatctg ccaaatgcag 1264501 atggtttttt caaattatac tagctgtgtc tgctgtgctc ttgcctgttt tgcggcttca 1264561 accatatttt tcaatgctgc aaccgtttct tcctgctgtc ttgttttcaa tccgcagtct 1264621 ggatttaccc agaagcggtc agtcggacag acggcaagcg catcaacgat aatattgtac 1264681 atttcttcag ttgacggcac acgagggctg tgaatgtcat atacaccaag gccaagccct 1264741 ttcaaatacg ggtggttttt taagtaatct aaaaatcctc cgtggcttct gctatgttcg 1264801 attgtaatca catcggcatc aagatcattg attgtatcaa cgatatcttc gaagttgctg 1264861 tagcacatat gtgtatgaat ttgtgtctcg tttttcacgg aagaagtggt taatctgaaa 1264921 gcttctgccg cccaagtcaa atactcatcc caatcgcggg ttttcaatgg aaggccttca 1264981 cgcagcgctg gttcatcgac ttgaatgatt tgaatgcctg cgtcttcaag cgctttaact 1265041 tctttgcgaa gggcaagccc gatttggaag gcgatttctt tcctcgagat gtcgtttcga 1265101 gggaaagacc agtttaagat tgtaaccggg cccgtcagca ttcctttcac atgcttggaa 1265161 gtcaatgact gtgcgtagac tgtgtctttc actgtcatcg gttcaataaa ttcaacatct 1265221 ccgtaaatga ctggcgggcg gacacagcgt gagccgtatg attgaaccca ggcatattta 1265281 gtgaaggcga aaccggccag cttttcaccg aagtattcga ccatgtctgt ccgttcaaat 1265341 tcgccgtgaa caaggacatc aagctccaat tcttcctgaa tatcaatcca tctttttgtt 1265401 tccgcattga taaagttttg atactgttca tcggaccact cagctttccg ccatttttgg 1265461 cgtgcgctcc gcacttcagc agactgcggg aagctgccga tcgttgtcgt cggcaaaagc 1265521 ggaaggccga gagattcatt ttgtagggct aaacgttctt caaacggaat cgggcgcttg 1265581 aagtctttat cagttaattg ctcaagctct ttcttttgtt cagaattggc gcctgttgca 1265641 aactgtttaa gcgcctggat atcagcctta gcctgctgaa tctcttcgct gatcgccgct 1265701 tttcctgata ctaagccttc tttcaaagct gtcagctcgg ccagcttttc ttttgcgtag 1265761 gataatccgt tcaataggtc tttttccaaa tgctcatcag ggtgtttcgc tactggaaca 1265821 tgcagcaggc tgctggaagg ctgaatccac agttcatcaa cttttgcaat gctgagaata 1265881 tcaagaacgg catcgagacg ctcttcaagg tccgctttcc aaatgttgcg tccgtcgata 1265941 acgccggctg ccagcacttt atctgtcggg aagccatgtg ttttaagctg ttccaggttt 1266001 ctgcctttgt cgtgaacgaa atcaaggcca attccctgaa ccgggtaaga gatcagctct 1266061 tcataagcat caacagaatc aaaatacgtc tgcaaaagca cattcaagga tgaaagctca 1266121 cttgtaatgc tttcaaataa ttcttttgcg ccgcgtacat cttcactaga ggcggtaacg 1266181 agcgccggct catcgatttg aacccatttt acgccttctt cttcaagctc tttcaaaagc 1266241 tgtacatata atggcacaag gcgtttttgg atcgcttttg cttcagacgg ttcatagcct 1266301 ttagcaagcg taacgaacgt ataagggccg acaatcacag gctttgtttc cacaccgtat 1266361 tcctgtttga tccggcgata atcttcgagt tgtttgtttc ttgtcagacg gaactcaatg 1266421 ctctcgtcat attccggaac gatgtaatgg taatttgtat taaaccattt tgtcatttca 1266481 ctagatacag cgtctttgat tccgcgggcg atagcgaagt atgtatcggt agcgtcagtc 1266541 aaatgtctga accgtttcgg gatccagttg aagctgactg ctgtgtcgag tacatggtca 1266601 tactgtgtga aatcagaaac aggcacaaca tcaatctgct ggtcaatttg tgtttttact 1266661 gcggataaaa atagttcgtc gatttgcttc aaaaacgtat ctttatcagt actgcctttc 1266721 caatacgctt caagtgcttt tttccattcc cggttcagtc cgattctcgg aaatcctaaa 1266781 ttcgatgttt tgatggttgt cattgtttct cctcctttat atgtaaaaca ctctctttca 1266841 cccgcggata caggctgcta agaggttttc tcacaacaaa aagcctcttt cccatgagag 1266901 aaagaggctt ttctacgtaa aacactgcct ctctcatctc tcagacacaa tctgatggaa 1266961 ttagcaccgt gccttatgag acatcagtct cggcgcgaaa agcagtgcgc cccatttcac 1267021 aatggtatta cggtcggttg ctgttggggt caaaaggcca atccctcgcc caactctcga 1267081 taagagaaaa tgttattaat tttttgaaaa gttgaatcat ttgttggtaa tcttaacagt 1267141 aattcaaatt cattgtcaac atagaatttg aaatttttat ttacatgatg tggtgtatat 1267201 tatataagaa aaataatctt atagggtcaa caaatgtgat tgctctgctt tttctgcgag 1267261 ctcatcagga gctgttaaat acaggaatcc attgcctgcc agcgtttttg caatatcaag 1267321 aggaagtgtc ctgcggatta gctgtgcgaa aacctcagat tcagaaagct ttctttgaaa 1267381 tgattcttct tcatagcttt tgattaaagc aagcgcaccg ctgacatgag gggcagccat 1267441 tgaagtgccg gtcagcttac cgtacttctt gttgggaagg gtggataaga tgttttctcc 1267501 tggtgccaca aggtcaatct ctttattcgc gttagaaaat tctgataatt ctcgcgctac 1267561 agaaacagat ccaactgcaa tcacttcatt ataagctgcg gggtaggaaa gctcttctgt 1267621 gcgttcgtcg ccgtcacctt catttcccgc tgcacaaacg acaagcactc cgtttttcac 1267681 tgcgtttttc actgcttctt ttagctctgg cacatcgctt ggccctccaa gggacattga 1267741 gatgatgtcg actttctgtt ccaccgcgta gttgatgccg ttaattatcc attcgtattg 1267801 tccgctgccg ttctcgccgc caagaacctt cacaatcaat aggcttgcct caggcgcgac 1267861 tccggcaatg cctccgtttg aatcattagc tgcaattgtt ccggcgacgt gtgtgccgtg 1267921 tccgttgtag tcggaaatcg catcttcctt gccgccgtcg tcatccgtga agttctttcc 1267981 gccgatgatt tgatttttta aatcagggtg gcttgtgtcg cagcctgtgt ctaatacagc 1268041 aactttaata tttttgcctt ttaccccttt tgcccacatt tctggcgcct taatcacttt 1268101 aatgccctca ggaagctcgt ttacatccat gatctgctca ttcgtcacat acgggatcaa 1268161 gcggatttca ccattcataa aaaagccctc cttttttatg cttgcaagtg gattcaaggg 1268221 tgttgcctca tattatatga aaaaagcaag cgctcggaca gagccatttg aagcattttg 1268281 aaaaaatagg atacacacca aagaattagt aatcttcaaa atattggatg gcttcaacat 1268341 gtatgactgg gattcaactg taagtcaagt tataatagtg ttggggaaag gagcagtgtc 1268401 atgaaactga atgaaaaatt atatgcattt ttttcagagc atgtggaaca aatggccgag 1268461 gaatggattg aaacgatgga ggaaagtgat ccgaattcgc tttacgccct acataatgca 1268521 acagtaacgg aagaattgaa agagcaggac agagaatttt accggcatct gaattacatg 1268581 tatgttttac cggaaaaaca atttctcgaa gagtttcaag agtgggtcat tgagctgacc 1268641 aacgatcaaa aacatctcga cacaccggtt cagtatgtca ttcgggagtt tatgagaaac 1268701 aggagattat atacgaagta ttttgagaag ttcgcagaag aaaatgaatc agcgtttgaa 1268761 ccgggagaga agcaaaaatg ggcagatttg attgtaaaag tatttgattt caccatttat 1268821 acattcgttg atcacgctga aatgaatgcc aagcagcaat taaacgccca aagagaaatg 1268881 atattggaat taagctcacc tgtcattacc ctgagcaaat caacagctct gctgccgctt 1268941 gtcggtgaca ttgataccga acgggcgaag tttattctgg aaaacacgct tcaagcttgt 1269001 gcgaaaagac gtgtggagca tctgttaatc gatctgtcag gtgttgttgt ggtggatacg 1269061 atggtggcgc accagatctt taaattgatt gaggcgctta atctgatcgg tgtccggtca 1269121 accctgtcag gaatcaggcc tgaaattgcg caaactgctg tacagctggg gattgacttt 1269181 tcgaatatta ctattaaaac caaccttgcc caagcattaa actatcatca ataaaaaaat 1269241 ccgctatctg tgatagcgga ttttttatga tgcgaaacat aaagatacga gaaaggatcc 1269301 cgcgaataat aagaggacga ggcaaaagaa cacccagtcg cgccggttca cgctcaatgt 1269361 cctgtagtat gtccggtttc tgcttcctgt aaatcctttc gattccatcg caagcgctgt 1269421 ccgttccgct tttctgatgg cgcttgccaa tagcggtatg gtatatcgtt ttaacgcact 1269481 gattttatta atgatgccgc tctccgccgc tcctcctctg attttatgag cctgctgaat 1269541 cagctggacc tcatccttta acagcggaag aaagcgaaag cctgcaatga caccgtacgc 1269601 gagctttggt gagagcctgc actgctggac aaggctcagc ataaatagaa tcggatcggt 1269661 tgtaaaaaca aacatcatcg ataaggcgga aaagcataaa atacgaaacc cgagagagat 1269721 gccgacagac acattatcgc tgttaatgga gatagggcct gcttgaaaca aaaaattatc 1269781 cggtgttgtc ggcacttttc caaaaactgc ggctgtccac acgcatccga atgctaaaat 1269841 caaaaacgga atcgtaaaca acaaccattt tttcaatggg attccggccg ccagtaaaac 1269901 gcccgcaacg atgatgatat aaaaacatgc cggagtgtaa gggttgtaaa taaacgacag 1269961 catgacgaca caacaaaaaa ccgccgccgc tttcacagtc ggattaatga gatgtaacgg 1270021 ttgcttcatc acgcacctcc tcttgaaatg ccatccattc atatagaagg ggaagggtga 1270081 gctttgcttt ttgaacaagc cctgtttctt gagaaaacaa ctgcgctgga gatccgtcaa 1270141 aggccaggcc tgtatcgtga agcacaagca cgctgtcagc atacgaagag actagctcca 1270201 tatcgtgtgt aatcataagg acagcagttc cctctgcctt gatacgttga atcatttcca 1270261 tgcattcagc cgccgtgcgg gcatcctggc caaaggttgg ttcgtctaat aataaaacct 1270321 ttacgtcatg catgagcata gtagctacgc tcagtcgccg tttttgccct tggctgatcg 1270381 caaacggatg atgatcagcc aaatgcgcaa gaccaaaacg ctgcagcagg tgttgcgctt 1270441 ttttctcagt ttcagcattt gctttctggc cgaacagaag ctcgtcatac accgtatcgg 1270501 tgacgaattg atgctcaggg ttttgaaaaa caaatcccat ccgtttacgc aattcttttt 1270561 ctttatattt ctgcagcggc tgatcataga gaaggatttt gccgctttgc ggtttcatga 1270621 gactggccag aactgatagg agcgtcgatt ttccagttcc gttcggaccg acaagcgccg 1270681 ttaaagagcc ttcgcgcaac gaaaagctga tgtctttgaa aatcgcctgc tgtcctctcg 1270741 cgaacgaaag gctgctgact tcaagcacac tctccccaga aggggctttc ttctttttga 1270801 catgcccggc aggaataggc tctttgaaca gcatctcttt tgataaagta aacggcatac 1270861 tcagcttttc ctgcagatga cagacctttg gaatggcgat gcccaatttc tttagtgtct 1270921 ccgcttcatg ctgaaataga tttttcgtca ggccatccag tgcctttttg cctgatttgt 1270981 cgagtacgat cgttctctca atccaaggcg cccattcatc aagctggtgc tcaatgacga 1271041 ggaggctgaa acctttttcc cgctgaagat ccttcatcag atgaacgaac tcccgagctg 1271101 agaaagggtc taaaagagag gtcggctcat ctaaaataat aagctcaggc tccatcgcca 1271161 aaatacaggc gagagccact ttctgctttt gtcctcctga aagggttgag atcatttttt 1271221 cttttaaatg ggtaatgcgt aatttttcta atacggcgtt gattttctct gtcatttctt 1271281 cttttggaat ttgcagattt tccagcccga acgctatttc gtcctccacc gtcagcatgc 1271341 agaactgctg atcaggatcc tgaaaaacga ccccggcatg ctgagtaatc gtttcggagg 1271401 tttcagcatc tgtgaccggc ttttgaaata gaaatacatg tccggactga atgccgtcgc 1271461 aagcctccgg atatagaccg tttaaacaaa gggcgagcga gcttttaccg catccgctcg 1271521 gtcctaataa taaaacacat tctccttttt gaagctcaaa cgaaatgtct tgaaaaaccg 1271581 gtttctcgtc ttcttcataa gagaagctga gctgctcaac cgtcagaagc tcatcaaagg 1271641 cttgcatgtt ctgacgcccg cttccgtttc tttttcagtt cctttccgag tgccattccg 1271701 tttaacacac ctgtataagc gagagagtcg ctgacagctt ttccgagaag ccccgccaaa 1271761 agcgcgccgg aaatgaggcg gatcacaagc ataatgagca gataacctgg tgaataggct 1271821 gcatagccag aaacaaagag atcatagata aagctggcta ctgaagaccc cataccggcc 1271881 agcataagga cagggagaga gtatgctttc cagcgtgttg caagaaatac agcctcagcc 1271941 ccgagccctt gaacaatgcc aatgacgatg accatcgggc cagacggatt tcccagcagg 1272001 cactcaacga gagcggcaat gatttcagaa acgagcgccg cacccggttt tcgaatcatg 1272061 tacgcggcga tcacagaaac gataaaccaa atgccgtaaa ttggttcata ggcgattggc 1272121 ccaaacatac ctgcaagtac gtttccgaaa tgtgtaaata ataaataaac aacggcaaat 1272181 acgatactga taacggacat gatgacaatt tcttttactt tccagctttt catgttatcc 1272241 ctgctttctg ttttttcttg atggactgtt agccgaaaga ttcacagtca tggtgatgtg 1272301 gtttgtttgc tgctcagcca tgcggaaaac ggcctccaat gtgctgaata cgtcatgcgc 1272361 atccccgtca agctcgctcg cgtaatggac accctgtacg aaagtgcctt gggcttttgc 1272421 aatgtcgaca gcctccataa tcaatcccat ataatccggc tcattcattg gataaagggc 1272481 aaattggcac ggcgcttccg ccttcaagcc tcggacagca tcttcattga cacgcttatc 1272541 acctttggaa agatatgtat ccccctgtgt gtcacccggg catccaatgg aaaacgtgcc 1272601 gttcatgacg atgtgttgtt cgctgtttgc tgcatgaagg taaatggctt ttgcagcatc 1272661 gaatacatga tcaatcgatc cgcgtaacac cgtgctgata tggtcggttt tcgtccaaac 1272721 cttggatgta tctgtttttt tcagcgcaga cttgatcaca ctgataaaat catccgtcat 1272781 cggatataaa gagaagcgaa aaccggcgat tctgcttgta ccgcaaatat gctccatttc 1272841 tccgacctcc tgtttttttg gtaaaataaa aaactgcata tcctaaggga atatgcagtc 1272901 atagatcgat taagcgcaca aaaaaataca ccattcggtc aacctgcact tccccacgct 1272961 ggtattatcc agatcgggtc ataagggatc aaagcgcgtt tcttccgcgc tttatctcag 1273021 ccaaaacagc acccctagtg ctttccgtat acaatttttt attttgacat cataatagat 1273081 gataagaatc attttgtaaa caacgaaatc atttttttca tatagggacg ggagaggatg 1273141 gtcaaatttg gaaaaaggac acatattaat tgtggaagat gaagaaaaaa tcgccagggt 1273201 tcttcagctt gaattggaat atgaaggata cagcgtcacg atcaaacaca atggcacaga 1273261 aggtcttgat gcggcagcgg aaggcgggta ttccttggtg cttcttgatg tcatgcttcc 1273321 ggggcttagc ggactggaag tgctgcgccg cttgagaaaa acggattcgc agacaccggt 1273381 catattatta acggcgcgag acagtattcc tgataaggta acaggtctgg acatcggtgc 1273441 aaatgactat gtcaccaagc cgtttgaaat cgaggaattg cttgcgagaa tcagggcggc 1273501 gctgcggcaa aatggaacaa aaactgaaga tatcggcacc tttcttacat atgacgattt 1273561 gcgggtgaac gaaaaaaccc gtgaagtgag acgcggagac aaagaggtgg aattaacgcc 1273621 gcgggaattt gatctgctcg tctatatgct aaagcatccg cagcaagtgc tgacacggga 1273681 gcaaattcta agctcagtat ggggatttga ttatatcggt gatacaaatg tcgtggacgt 1273741 ctacataaga tacatcagaa aaaaactgga ctatccttac gaaaaacagc tgatccatac 1273801 gattcgcggg gtcggctatg ccattaaggg gtaaacgatg aagctgaaga ccaagattca 1273861 tctatacact tcgatatcac tgttgatttt attaattttg gttcataccg cagtatatct 1273921 cattttttcg tctgcgctga catcaaagga tgcggcccgg cttgctgatg agacggataa 1273981 cattgccgaa gcgctgcgtg ccgctgaaac agaaggagtg gctttgcagg atatgctgca 1274041 ggcctatctt ccggcaaatg gcatggtgcg tgtagtgaat ggtgatcaaa aagccgttat 1274101 gacgatcaca aaagaaaaag cctataaaga ttttcctctc tcttttcata gcggcgaaac 1274161 ggcagatgtg aggaaacctg acggcaagct gtttgccgag gctgctgttc cggtgatttg 1274221 gaccgatgga caagtcgtgt ctcttcagct ggttgaaaga ctggagaaca cagaagagag 1274281 tctgtttctg ctgaaaatca tcttaatcgc tgcaagtgct gctgtctgca ttgcttcttt 1274341 ttttgcaggc agcttgctag cccgccgaat catcaatccg atcagacgat taatgatcac 1274401 aatgaaagac atacagcgag acaaagaatt taaaacgatt tctttagaag gacagtccaa 1274461 cgatgaattg tatcaaatgg ggctgacatt taatgaaatg gcaatgatgc tgaaggagca 1274521 ctatgataaa cagcagcaat ttgttcaaga tgcttcacac gaattgaaaa ccccgctcac 1274581 tattatagaa agctacagca gcctgatgaa gcggtggggt gcaaaaaagc cggaggtgct 1274641 tgaggagtcg atagaagcca ttcactcaga agcggtgcat atgaaaaaac tgaccaatca 1274701 gcttttggcg ctggccaaaa gccatcaagg actcgaggtt gatctgaaaa caatcgatct 1274761 gattaaagcg gcgcgcgcgg ttatgcaaac gctccagtcc gtttatcagc gtgacatatt 1274821 gcttgaaaca gataaagaga gcctgcttgt aaaggcagat gaagaacgca tcaagcagct 1274881 gttgaccatt ttgcttgata atgcaataaa gtatagtgaa aagcctattg agatgtcagc 1274941 cggaacgagg aatggacggc catttctatc agtgagggat gaaggcatcg gaatacctga 1275001 ggagcatatc ccgcatttgt tcgaacggtt ctaccgggca gatgaggcac gaaacagaaa 1275061 aacaggcgga acaggtttag gcctttccat tgccaagcaa atcgctgatg agcatggcat 1275121 tgagctgtct gtcaaaagca agccgggaca aggaacagct gtcaccatgc aattcagcga 1275181 acagaatggg ggaggccgat gactaaaaca ataaaaacag tatcttttgc tgcagcagcc 1275241 attttagttg tcatcatctg tacgtttctc atcattcggc aaacccatga gaacgtattg 1275301 tcaaaggaga ctgtcgtaaa aaaagtcgaa gcctcttatg aaggcaaggt cacgaaagca 1275361 acacaatcaa aggataaaaa aacatatgat ataacccttg aaaatccaaa gggaacttac 1275421 tttgtaaaag cagacgcaat atcggctgac attctttcaa tgaatagagt aaaagcagtg 1275481 aatccatctg ccatgacaga aaaagaagcc gagcatctcg cgcttgagcg ggtgccggga 1275541 acggtcaaaa aacaaacacg gcaaagtcaa gttgccactt ataccataca aaaagaagac 1275601 gggaaaacat acgaagtgaa ggtagacatg caggcaaaaa cagtcttgtc tgccgatcaa 1275661 atcagcagca aagatcaaca aaaaacgccg attacgaaaa aagaagccaa aacaattgca 1275721 gagcgaaaaa cgggcggaac agcggatgac gcagatctcg aagaaagtga gggcactctc 1275781 atctttgaag tagacgttga tcttcctgat aataaggaag cgacagtgaa aatcaatgcc 1275841 tacacaggaa aggtagctaa cattgtgtat gaagactgac ggtttctcat caaattctca 1275901 tcttgctctc gttttccttt catgttgagt atgtaaactg tactcataca aaacaaagga 1275961 gggctcacaa atgctcaaga aaaaatggat ggtcggtctt ttagcagggt gcctagcggc 1276021 cggaggattc agctacaacg cgtttgccac agaaaacaat gaaaacagac aggcttcttc 1276081 taagacggat gcactcactg aacaagaagc agaagcaatt gctaaaacag ttgttgacgg 1276141 cacagtagaa gacattgaca gagaccttta caacggcaaa gaagtctatg aagtggagat 1276201 tgaaaaagaa ggtgaagact acgacgttta tgtagatatt catacaaaac aagcgcttaa 1276261 tgacccgtta aaggagaaag cagaacaagt cgccataacc aaagaagaag ctgaagaaat 1276321 tgctttaaag caaacaggtg gaaccgtaac agaaagtaag cttgacgaag atgacggtgc 1276381 ttacatctat gaaatggaaa tccaaacgaa gcaaggaact gagacagaat ttgaaatttc 1276441 cgcaaaagat ggacgcatta tcaaacagga gatagatgac taatcaaaac ccccgctgca 1276501 gcgggggttt ttcatgataa gaaaccttct tttggacaat ctaagtagaa aaggaggcga 1276561 aacgcatgga aaagaaagag gagcaataca tcaatcaggc tgaatatgtc cctcatccga 1276621 cgaaggaagg agagtatgcc ttatttcttc atgaaacgta tcatttgctt tctgaagatg 1276681 acgagacaca aacaacagaa taagggctta ggcccttgtt ttgttccgta attgtgatgt 1276741 aagcgcattt attacttttt tgagttgaca tagcttgttt ttttctgtaa tctcagtgtg 1276801 tcaattcaat taggaacttc gttaggtgag gctcctgtat ggagatacgc tgctgcccaa 1276861 aaatgtccaa agacgccaat gggtcaacag aaatcatcga cataaggtga tttttaatgc 1276921 agctggatgc ttgtcctatg ccatacagtg ctaaagctct acgattgaag gcgcccgcac 1276981 gctttttttg ccgtgcttct ttcaccttca atcccgaagg ctttttttat gcctttaaaa 1277041 cgaaaccaat caaaggaggt gcggagtatg gattctcccc attcgagtca atctgaagaa 1277101 gtacccatat actatgacag caagacaatt gattacacga tgaggagacg aactgccgca 1277161 ccttctggcg aggccggcac gtctccgtag aggaggtacg agtcccgatg gttcaaaaca 1277221 tgacctatga cgaactcatt ttacgcatca ttattttact gcgagacggg aaaatcaggg 1277281 attttagaag tgttattgat gagcttcagc cctatgacat ggcatttatt tttaaagaaa 1277341 tgccggaaaa acatcgcgcc cgctatttat cttatttaac tgtagacgat atcactgata 1277401 tgatcgggga gctggaacgc gaatttcagc ttgtcgtctt aaataaagtc ggaaaaacaa 1277461 aagcaacact ggcgatgaac aaaatggaca acgatgacct cgctcaattg cttgaagaaa 1277521 tggacgaaga actgaaggaa cagcttttat ccagcatgga agcgtcagaa tcaaaagctg 1277581 tacagctctt gatgaattac ccggctgatt cagcgggacg catgatgaca aaccggtatg 1277641 tgtggatccc tcagcattac acggtaaaag acgcggtcgt caaactgaaa agcttcgctg 1277701 aaatagctga atcgatcaac tacttatatg ttattaatga aagcaaacag ctggttgggg 1277761 ttctttccta ccgcgatttg attctgggtg aacctgaaga aaaggtgcag gatttaatgt 1277821 ttacccgcgt catatcagca gatgctcttc aggaccagga agaagttgcc cgcctgatag 1277881 aacgttacga ttttttggca ataccggttg tagaagaaaa caacgtgctt gtcggcattg 1277941 tgacggttga tgatattatc gacgttgtta ttcgggaagc tgatgaggat tacgaaaaat 1278001 ttgccgcttc cggtaaagac atcacctttg acacaaaagc ttacgtggcg gcataccggc 1278061 gtctgccatg gctgatttta ctcttattta tcggactgat ttcaggaagc attatcagct 1278121 attttgaaga cgcgctgaag caggttgtcg cgcttgcgtt tttcatgccg atggtgtcag 1278181 ggatgacagg aaatacggga acacaatctc ttgcggttgt catcagaggt ttgtctaaag 1278241 aagaaatgaa caaaaaaacg attgtgcgcc tgatcttccg ggagttcaga acaagcattt 1278301 ttatcggagc ggtttgttct gtgctgattg cgattgtttc tatcatatgg caggggaatg 1278361 cgcttttggg atttgttgtc gcctcttcac tgttcttaac cttaatcatc ggcacgatgt 1278421 caggaacgat tatccctatt attttgcaca aactgaaagt agacccggcg attgcttctg 1278481 gaccgctgat tacaacgtta aacgatattt tatctttatt aatctacttt ggcattgcca 1278541 ctgcattcat tcactcatta taaacgtaaa aagtccgtct caactgcgag ccggactttt 1278601 attatttaac ggtttttgta ccgaaagtga gcattaagct gcccctccag catttttttc 1278661 cgcacttgcg gatcgttttt taacatctgt tcttttttgc gcatatcctt taaaatctct 1278721 gccgtctgta cgccgtcttc acgcttattg gcgatatcca tcagccgctc cacatcggca 1278781 aaggagtatt ttcttgtccc ccttgaagaa cgctgcgggt aaatgagctt tcgttcctca 1278841 taatacctga tctgtcttac ggacaatcct gtcaattcac tcacaattcc gattgaaatc 1278901 acttttttgt ctttataaga atgatcttct gtggtcattt ttccacccct ggatgtcttt 1278961 tgataatagt atataaaaaa caaagagaaa aaacctgacg cttgtcatat tttctaacat 1279021 caaatagaag atttttgaaa aaatacggaa gaaaaattaa caagaataat gcgtaacacc 1279081 caagcgcgtt ttatccttta tgtaacgaat caaacgagga ggaaggataa tcatggagga 1279141 agaaaaagca gtctcactgg caaaagaaat tatagagttg gatatcaagc gtgatgaaat 1279201 gctggagacg tttatgcagc ttgccggaga acaggctttt caattattaa gatcggttca 1279261 aaacggacaa taccgaaaat cttcgtaaac ataaattctt tacattagat tcataccacg 1279321 ttcatttaaa aagagtatct tttgtatagg atacctcaaa atgaaggagg acgctatgag 1279381 taatttattg aaatccgctt tagaaaaaga acgacgccat tattctgaaa aactctatca 1279441 gataggggtt tataataaag aggtcatgaa caaaatgacg atttctgagc ttcggaaaga 1279501 atacgcttat ttctttcgaa gcattacaaa tcataaaaat tatccttata caagataatg 1279561 tataaggatt tttttgcttt tagaaggaat ttctcgaatt atagcgaata cgtatagtaa 1279621 gggactgaac tcttattata tgtaagggtt ttcattattt ttttataaaa atcctatata 1279681 cgaggtagat atgatgagat tatcgtttaa cgaagaagaa gttgagcgtg cgatgaattt 1279741 gtacagagtt tttgcaaggg ctttcaaaag tgtgtccgaa catagtatcc gtgatagcaa 1279801 agagcacggt tttaatccca ctgaatttgc tgtactggaa ctcctgtaca caagaggccc 1279861 gcaaaaatta cagcaaattg ggtcgagact tctgcttgta agcggaaacg tcacatatgt 1279921 tattgacaaa ctagaaagaa acgggttttt agtaagggag caggacccga aagataaacg 1279981 ctctgtttac gcacatttaa ctgacaaggg aaatgagtat ttggataaaa tttatccgat 1280041 tcatgcactg cgtattgcga gagcgttttc aggtctttcg cctgatgaac aggaccagct 1280101 gatcgtcctg ctcaagaaag caggcataca cagccagcat ttgctgtttc gttaactatt 1280161 ctacactctc tatttcagga gagtgttttt ttgtttccat atgattcttt ttaaaacatc 1280221 tttaatcttc ctatcagaca tttcgccaag gtatccattg acgtgttttt tatactcctt 1280281 catctgttcg ttcgattgaa aaaatgccgc gatatactct tctgctttct gcatgtccca 1280341 gtttctcata tctgtgacga gtttcctttc atgtagaagg tttaaattca tttcctcctg 1280401 tcccggcagt gcatgataaa taaataccgg aagccgtttc tgtaagcatt cactgatggt 1280461 cacgcctccg ggtttagtca tgatgcctgt cgcctgttcg tacaaacggt tcatctctgc 1280521 tttgctgtga aggtaaggaa tcgcctcaat caaggggtgg tgtaaacttt tgacatagga 1280581 gtagagcttt tcgtttctgc cgcataatat tttgtataag atctttccgc ctggcgacag 1280641 ttcctgcacc cattttaaaa tcccaccgac ccccatactg ccccctgtga tgatgatggt 1280701 atatggcggg tggtgctgca aggtatctgc tgattccatt tcaaaatttt ggtgaactgg 1280761 aatgccggtc aagtatatgt tgttctgatc gataccctct gatattagct gcttctttac 1280821 ttccgtgctc ggaacaaaat ggtaatcaat gttcttccgt ccccataatt gattcacgaa 1280881 aaaatcagtg tatacattca caaccgtcag attcggatat tcaggcttta gtcggttcag 1280941 cagataagaa ggcagcgcat gtgtgcagaa ggcgatatca ggctgttttt cttggaggat 1281001 gtgcctcatt tgctgtgtga acagccattc gtacatgaaa tagcgtttgt catgctgaaa 1281061 ttctccgcag gcgaggagcc tgtaaatgcc gctgtacgtt ttcgggaaat attgaatcca 1281121 ttttaaataa gccacggagg acaatttttc taaccgccta tacgaatgtg aaaagatatc 1281181 aatcttttca gctgccagcc cttgagactc taattcagcc tgcaatgcat cagccacatg 1281241 atgatggccg gtggaaatgc ttaaaaaagg aaaaatgaga atgtttttca tgacagtcct 1281301 cctaaaaaaa tatggcaact atattttgag gagaacgttc acaaaatata agggtgtttt 1281361 tgatcataag gaaggtgaaa agatgaaaac ttgtttcctt tccatatgga gagtggttga 1281421 tccgatttat ttcttttttt caaggctaag cttgattgac aacgatcaaa aaagcgtttt 1281481 tcgagtcagg ctgacgaagt acaaaggaca tcatgtcgtg cttagcgacg gaacgcatat 1281541 aagaaaaaat gatgtgctcg ttaaaatcca cctgcataac ataaagctga tcagggagct 1281601 gcaaagcatt gagagcgcag tcagaaaggg aatcattatt tatcagaaag tatatcaatc 1281661 gatgccgctt cttcttgact atatcaacaa tcataaaaaa agcgagaaaa tcaaaggaat 1281721 cattgggatt acaatgcttg acaaaggtgt ggaaaggctc ggctttgatg tgatcacccc 1281781 ggtgaaccct ttttacagat gctttaaaaa agtgtctcat gtgccgattt tatatttgac 1281841 ttcaaagcct gtgagcttgc ggcatttacc gaattcatcc tatttgttta tctcaaaaga 1281901 aaagctgcag aaaacctatc aaaaaaaaga ctgatgcctc ggtcagcaca gtcttttttg 1281961 attaaatctg atgaaatgtc acttcagggc ggcttccgac acggatattt acgccggttt 1282021 gtcccaagcc ctcgctgata taaaatggtt tatcgtgatg ataatgaagg cctttaatca 1282081 tgttcattcg cacgagcttt cccattttca ccaaatgata cggttttggc cagtgaattt 1282141 gcccgccgtg aaaatgccct gacagcaggt aatcataatg aacatctttc atatccagaa 1282201 taatatttgg gtcatgtgtt aagacaagat gatagccatt ttccagactt tgataagagc 1282261 cggtgatatt actccgattc gtactgtaat catcaatgcc gataatattg actggtcctg 1282321 cagccgtctc gattcgaaca tgttcatttt gcagcgtgat acagccgttt tcctctaaaa 1282381 ctcgcttcaa tctctgaaag tcctcttctt tcaatacata atcgtggtta ccgaacaccg 1282441 cgtacattcc atatgcaggc tttagctttt gcaaggcgtt caagtaacct gccagtttcg 1282501 gaatattacg tttccgatca agaaaatccc cggtaagagc aatgatgtcc acaggctgat 1282561 cttttgttaa atgatacagc tcctcaggtg agactgaaat gttttccaag tgaagatcag 1282621 ataaatgaag gatatttaat ttttttctgg ctggaaggcc gtctttttgg tcgattgaaa 1282681 tggtgttgac tttcacatct tttgtattgc ggttcgcttt atatagaaat ggcacaaata 1282741 cgagtatggc caatgaaagt aagattgtaa acaaaatata tcccctccct tctatcagta 1282801 tagtaagtga tcaagcccta tggatagcgg gaattaatgg gtagagacag gttgaaaaac 1282861 ggattgtcat atgatgaatg atttggaagg gaaaagggat aataaatttt gacacatgag 1282921 gcagaacatg ccgacggagt cagaataaca aatggatgtg taagcaatgt tacgattgat 1282981 gagacaacaa aaaaaagaaa catattatct ctggatcgca ttatttcttc ttttattgta 1283041 tgtatccccg ctttttattt taaaggaaga tgcccatatc cgggtccacg ataatttaga 1283101 ttccaacatc gcttggtaca aggttctggc cgatagcgga gaaatcgtcg gcaaggttga 1283161 cgctgccatt ccgcaaatca ttaacgggct gccccgggat gcctttggca ccgagtggag 1283221 cggaattgtt tggctccatg ctttcttttc ttccatgacc gcctatgcaa taagccagac 1283281 ggttacaaga gttgtcgctt tttttggaat gtatgtgctg ctgaagaaac atataatccc 1283341 ggaaccaaaa gcggctttca tccgaattgg cgtatcgctt gcatttgcct taacaccgtt 1283401 ctggccttcg ggaatgctga gtacgcttgg gtaccctttg gcactgtggg cttttttaaa 1283461 tatccgaaaa ggggatatct catggagaga gtggctgacg ctgggcttgc tccctctata 1283521 ctcaagcttt gttctaggct tcttcttttt cctggcaggg atggcgtgtt tttggctgta 1283581 tgatgccatt acaaaaagaa gatggaattt gatgttctta ggcagtattg catttatgac 1283641 gagtatctat cttttcgttg aatatcggct tgtctattcg atgctgtttg agcacgcacc 1283701 gatgcatcgt atcgaattta tctcatctag gcatgacgtt tggcattctc ttcgactatc 1283761 cataaaaaac tttgtctatg gccataatca tgtgatgacc gttcataccg ttgtcatcct 1283821 tccgatcctg atggtcgtat ttgctgctct gctgttcaaa cgaaatcgga caaagccaga 1283881 aaatgtttat ctgtttttat gtgtgcttaa ttacgggttg tcattatggt atgcgttttg 1283941 gttcaacaaa atttgggctg ttccaaagca gaaatttgct tttttagcag aatttaattt 1284001 tgcccgtttt cattttcttc ggccgcttgt tatatacgtg agctttgcgc ttgctttata 1284061 tctcatttgg cggatgggga aaggatggaa atggcttgtg tacgccgcag tcgctgcaca 1284121 gctgatggtg ttggcgcctt ttaatgaaga atatacgtat ggtgttcatt acaacgcgcc 1284181 gacattcagg gagttttatg catcagagca attcaaagag attaaggaat atatcggacg 1284241 tccgcaagat tcgtataggg tggcgagcat cggactgcat ccgtctatcg cccaatataa 1284301 cgggttttat acgttagata cgtataacaa tctgtatccg ctctcatata aatatgaatt 1284361 tagaaaaatc atcgaaaaag agctggaaaa aaattctcgg ctgaaacaat actttgatga 1284421 atggggcagc cgctgctacc tttttgtcga tgaactcggt aaacgatatg atttcaaaaa 1284481 gaactcgaag aaaacgatca acaaccttca attaaataca gatgtattta aaaaaatggg 1284541 tggacggtac attttttctt cagttccgat catgaatgct gaacaaaacc atctcgcgct 1284601 cgtaaagacg tttgaccata aagattccgc ctggcgcatt tatttatatg aaacaagata 1284661 aggaggatat cgattgaaac agtcacagcc agtattaacc atcgtcgtcc cgtgtttcaa 1284721 tgaagaggaa gtgtttcaag aaacaagcca tcagctgaca gaggttgtag atgatttaat 1284781 tgaagaaaaa ttaattgctg aagacagtaa aattctgttt gtcgatgatg gcagcaaaga 1284841 ccgcacttgg gctttgattg ctatggagag cataagaaac aagaaggtta ccggcttaaa 1284901 attagcctgc aatgtcggcc accaaaaagc gcttttagcc ggattgcata aagcgaagaa 1284961 taggtcagac tgcgtcattt cgatcgatgc tgatcttcag gacgacatct ctgtgatccg 1285021 ggattttatg ctgaaatatc atgagggctg cgagatcgtt tacggtgtac gccggagcag 1285081 aaaaaccgat acctttttca agcgcacgac cgcgttaggg ttttatcgtc tcatgaataa 1285141 acttgggatt aaattaattt ataatcatgc tgattttcgt ttaatgaata aaaggtccct 1285201 tgaagagctt gagcgttatc cggaagcgaa tctgttttta agaggtattg tccccatgat 1285261 cggctttaaa tcggccgaag ttttgtatga ccgcaaggaa cgctttgccg gcaaaacgaa 1285321 atatccgctg aaaaagatgc tatccttcgc ttttaacggg attacttcat tcagtgtcgc 1285381 accaattcga ttctttacgc ttttagggtt tgttttgttt ttcctcagcg ctgtggcagg 1285441 gattggcgcg tttattcaaa agctgctcgg ccatacgaat gcaggctggg cgtctcttat 1285501 catatccatt tggtttttgg gcgggctgca attgatggga attggaatca tcggagagta 1285561 tattggaacg attttttctg aagtgaaaag acggccgaaa tacgcgattg atattgattt 1285621 gtataatgaa cagctgagcc cgcttcagcg ccaggaaaaa gagcggttag aaaaaaagta 1285681 cagttaaaca cggaaagagc tgacttcatt agtcagctct ttttcttcaa ctgatgcaat 1285741 atagcgctaa gcggttcgtc ttgcgggttg cggtaaaaat caaaaaatgg gcagccctgc 1285801 ttcttaattc gatcgatgac cgtatcaatt gtaaacagag cgggtgttaa agatgattgc 1285861 acctcatgcc agtagagcgg ggctgcaaca gtcccaagct catttcctct cgttgaatag 1285921 ggacagataa tcgtttttcc ttctgcatgc tgcaaataat caagatacaa tttgcagtgt 1285981 ctgtttttaa tcaagcgttc agtggtaaag agctcgggaa atgcattggt gcagtactct 1286041 gcgatcagct gcgtaaattg gcgtgtttct tcatacgtaa atgcctcggg agacaaggga 1286101 atataaagct ggatgccttt gttgccggac agcttcgggt acgatgtgat gccaaaggaa 1286161 tccaacagcc gcttcagttc atttgcggcc tgcacggcca taagaaagtc atctcgcgaa 1286221 ggcgggtcta aatcaatgac aatctcagcc ggacgcctgc ttttaatggt ttgaaaagga 1286281 acgtgaaact ccaaagcaag ctggttgcaa agccatagca atgtagacat atcctcacag 1286341 acaatatgtt catggcttcc atcatagaaa gactgaacaa aatccggcgc atagtccggc 1286401 ttgttttttt ggaaaaatga ttcgctccta gatccatgcg gatagcggat gacggtgaca 1286461 gcccggtttt tcagaaatgg gagcaggtag tcactgactt caatcatata ctgaataaaa 1286521 tcttcttttg tttttttatt cttttcaaat atgattttat ccaggcttgt gaactggagc 1286581 tttgggtgaa ccggtttgga gtgtcgtatg acttgcgcat acgtgcattc ggtccagtcc 1286641 atttggaatt cgaaaccgat aaacgatacc tctcttaatg tgccttggag aattgttaag 1286701 tattgaacag ctgcacaaat cgaaggttca agcgtaaatt cgcctgaggg tgtttgatgt 1286761 ccgtgctgtt ccataatctc gcgtatagcg cttttttcct catcacgcat tccgtgcgag 1286821 acagaggcaa tcggtgtcat tattccgttt tttaacaccg ataccgtcag aaacccgttg 1286881 ttagggttga accctgttat gcaaacataa gcttgtttaa agtttttata tttgagccaa 1286941 tcggacgacc gcttcttttc aagccatttg ctgtttgttt tcttcgctac aattccttct 1287001 ccgtcatatt ttattaccat ctcccagagt tgatcaaaat gatcataaca gggaatggat 1287061 tgaatggttt cttttgcgta aggatctgga gatgcaggaa gctttgctgc ggatatgagt 1287121 tcacgcagcg attttttgcg gtccaaatac gaaagaagcg ttacatcttc tccgcttcgc 1287181 tctaacaaat caaaggcgag aaagcagcac ggccgcgcgt ttgccgattc ctgaatcttg 1287241 tctggccttt tcaaacgccc ccgcacttga aggtgttcaa aatctgcacg acagggattc 1287301 accaaacata cgatttcacc gtcaagtgtc agcggaagct ctttttctag gtgctgaaag 1287361 gcagttttgg cgaattgtgt gatttcaggg aaggtgctgc tgagctccac accatttctg 1287421 ctggttaagg tcacacctga agaatggatg cggagaatac agcggtaccc atcatatttt 1287481 acttcgtaac gccattctgc tccgattggc ggtgacgaag ttaagaccgg ctgcatggta 1287541 aacgccatgc gctatgatgt gccggaggct ttttttctag ttgttttttg ttttttatct 1287601 ccggctcctt tcggttcagc ggcttgtgca ggtgcggcag ccggtgtctc ccggttcggc 1287661 cttctggttc tgtcgatgct ggcttgcaga gcgcttacca ggtcaatgac atcttcacga 1287721 ggtggcgctt tatcaggagt gacagccgtt tctttatttt ctagcttgtc gttgactctt 1287781 tgcagcagcg cctgtcggta cgtgtcttca tatttctcag gctcaaactt agcagtcagt 1287841 tcatctatta atgtgatagc agtttgcagt tccttatcgt ttacattcga ttgatcaggt 1287901 acacctggga cttgagcggc gcttctgacc tcatcgggat aatggataga ctccatgacg 1287961 atacaatttt cataaacgcg gagaatcgcc agctgctgct ttgacctgat tgtcatattg 1288021 gcgataccga tctttccggt tgagcgcagc gcctcacgca gcagggtata ggccttcgtc 1288081 ccattatccc cggggccgac aaagtaggag cggttaaaat aaatcggatc aatttcctga 1288141 agctgaacaa agtcaacaat ctcaactgct ttctcctcat gctcctgttt taagcttttt 1288201 aaatcttcgt ctgtcagcac tacatatttt ccttttacat attcatatcc cttcacaatt 1288261 tcatcaggac taagagtttt ttcgcaattt gtgcaaactt tctcgtattt gattggtgcg 1288321 tgatcctctt tatggaggct gcgcagttta atatctttat cttctgtggc cgcatatagc 1288381 ttgatgggga tgtttactaa tccgaagctg atcgatccct tccacattgt atgcatatcg 1288441 ataaacccct ttttttcttt agtgtgaaga gaaggagtac gattcatgtg tagtaactta 1288501 tgggtgaaaa aaagccggcg ctgttattgc gacggctgtt caataatgaa ttgttcgaat 1288561 tgttccggag gtattggcct gctgaaaaag aagccctgca aatggtcgca gcctttttca 1288621 aaaagaagct gcttttgagc tgcattttcc acaccttcgg caatcacctg caaagacagc 1288681 tgatgcccca tggcaataat agctccggta atttgctctg atttaggatg ggtctgaata 1288741 tcgtcaataa atgatttgtc aatcttcagc ctgtgaatcg ggaagtcctt caaatagcta 1288801 agagagctgt gaccagtacc gaaatcgtca atactgattc tgattcctaa ttctgttagg 1288861 gatgacaaaa cctttttgga gtgattgaga ttgtccattg tcatgctttc cgtcacctcc 1288921 acttcaagaa gctgcggagg aagctggtac ttattaagcg tatccttgat gaggggaatc 1288981 agatctttag attgaaactg tctggcggaa atattaatgg cgacagaaag atcatagcct 1289041 ttgtcatgcc aaatccttgc ctgcttgcat gcttcatcta taatccactt tccgatatca 1289101 ataataagtc ccgtttcttc tgcaacaccg atgaattctc cgggcggacg cagttgcccg 1289161 tctggtgtca caaggcgtat cagtgcttct gctcctgtca ttttttgttt tttcacactg 1289221 aattgcggct gataatgcaa gacaaatcta tcgttttcga ttgcttctct gagtaccatc 1289281 tcttggttaa gcttaacggt ttctttgttg ccgattgaaa aagaatagta tctgtatttg 1289341 cttttgtttc gttctttagc cgcatacatc gccatatcag cctttttcat caattcaagg 1289401 ccatccgtcc cgtcttttgg agatatcgca atcccgatac tgacagatgt gacaagggtg 1289461 tgatcttgaa ttttgaaagg ttttttgaat ttttggataa tttttcttgc taaaacatct 1289521 gcttcgcctg ttcctgtatt ggcgtctgtt aatataataa taaattcatc accgccaaga 1289581 cgggcgataa atccgttatc agggactaca gatgacaggc gtttagctgc aaactgaagc 1289641 aattgatcac cgacattatg ccctaatgca tcgttaatca ctttaaaccg gtttaagtca 1289701 agaaagaata caacagtgtt ataatgcaag gaatgctcgc gattcagcac ctttgttaga 1289761 tgagagatgg catgccttct gttaggtaag tctgtaagcg aatcataatg agccattcta 1289821 tggatttctt tttctgcttt gtactgcttc gtcatgtctt tacaaatgac ataaatgctg 1289881 tctagttcct gattgacctc aacaggtata agcgtaatat ttaagtgaaa ctggcctttt 1289941 tcagtgataa gatcgctatc gctgttcatc gcttgtttat cttttttaac ttgctcaaaa 1290001 aggcgcttaa ccttcagtga tgtgtaattc ctccagtcat gcatgctgaa gccaaatttg 1290061 ctgatcattt cctcaccagc gtgattggaa gatattatgt ctccttctaa tgataaaata 1290121 aaaattgcat caatattgtg gacgattaaa gactgaaatc gctgttcgtt atcctttatg 1290181 cgttcgctct gtttaataaa ctttcgatct gcatgggaac tgaataacaa taacgtttgg 1290241 atacaaaaaa taattaaagt aacaaaaatt gaccaatgaa acgtttgcac ctccatatgg 1290301 cttccgggcg gagccatgtc cttatggaaa gttgccgcaa gcatccctgt gtagtgcatg 1290361 cccgaaatcc caatgcccat tacaattgaa ctgacgcctt tatagaatat aagatgctca 1290421 gaatgttttt ttacggccaa gtcaaagaat atttttaacg agacgaaaga ggctgcaatc 1290481 gcaatgataa ttgaaactgt aaataaaata ggttcgtaaa taatcattac ccgggaaatg 1290541 gcagacattc cgatatagtg catagaagca atagatgcgc caagcacaac tgatccggta 1290601 agcagtctgt aatatgtaag aatgtgccgg ctgacaaaat ataatgacac aaatgatccc 1290661 gaaacagatg cgccaatggc tgccattaaa ggcatgaatt catattccat cggcatttcc 1290721 atatggacgg ccatcatccc tacaaaatgc attgaccaaa taccgaatcc cataataagt 1290781 gagccgccga tcagccaaat tttacttttt aagcctgtat tgatggtgac tttccttgaa 1290841 agttcaaggg aaatatacga ggcggtacag gcaattagaa tagataaaca tatgagagtc 1290901 gtattatatg taacgtgtat ttccaaatgg agattccccc cgtatcgtgt gttccagtct 1290961 tgttgactct ctttattatc ggctgcttaa ccgcagagtt tcagccttca aaacgataga 1291021 aatacgaggg agatctattt ttagttcaac tgaccgtgaa aaatgtgtta aaatcatctt 1291081 gatgttttcc gaaaagagaa aaatgtatga tacataaaca tgaaacaagg gagttggtgg 1291141 ctatcgaaga gctggttatg tcatggattg aagcatttaa aagcttatct tattttggaa 1291201 tatttctagc gctcagcatt gagtttattc cggccgaagt cgtcttgccg cttgcgggct 1291261 attgggtatc taaaggcgat atgacacttg ctggcgttgt tttggcagga tcgcttggag 1291321 gagtggccgg tccgcttacg ctgtattgga taggccggta cggaggaagg ccgtttcttg 1291381 aacgttttgg gaagtatctc tttattaaac ctgaagcgct tgataagtca gataattttt 1291441 tcaaaaaaca tgggggcttt gtcgccttca gcggccgttt cttgcctggt atcaggacat 1291501 tgatttccat accgtgcgga attgcaaaaa tgaatgtttg ggtgttttcg ctttatacat 1291561 tcattgctat gcttccgatt acatttgtat atgtttatct cggtgtgaag ctcggtgaaa 1291621 attggaaggc agtcggctct attcttgatc aatatatgct tccgatcggg atagcgattt 1291681 tggcgctgtt cctgctctac ttactgatga aaaagaggaa gaaacgcacg cactccgaac 1291741 aattatctgt atttttgaaa aataaacgtt gacaaatcac tgcgctgcgc atattattga 1291801 cgtataaaat catatttctt gaaatcccaa aggggagtag cgtccggaat gtattccgga 1291861 aacaaagtcg tcatttcatg gattgtatcc atcggctttg ttggcatgcc tgaattcatg 1291921 tctagcaaga cctttgcctt atgtcggcaa aggtcttttt tgcatggtcc ggccggcata 1291981 agatcggatg aagagaaaga aaacaacttt tttgggaggg tatcatttat ggatgcagca 1292041 ttattattag agtatggttg ggttcttctc gtcttgatcg ggctggaagg gattttagcc 1292101 gccgataacg cgctggttat ggcggtaatg gtaaaacatt tgccggagga aaaaagaaaa 1292161 aaagcgttat tttatggatt ggcaggggct tttgttctgc gatttggctc tttatttgca 1292221 atttctttct tggtcaacgt atggcaggtt caagcgattg gcgcgatcta tttgctgtat 1292281 atctcagcaa gccacttatt gaaaagatat gtatttaaga aagaagacac acataaagag 1292341 acgaagcaaa gcggtttttg gccgactgtt ttaaaagttg aactggcaga tatcgcgttt 1292401 gctgttgatt ccatcttagc agcagtagcg ctggcggtta cacttcctgg gacatcactc 1292461 ccgaagatcg gcggacttga cggaggacaa tttctcgtca ttttggccgg cggtatcatc 1292521 ggactggtga tcatgcggtt tgcggcttcc atgtttgtga agttattaaa ggaacgtcca 1292581 agcctagaaa cagcagcctt tgtgattgtc ggctgggtcg gagtgaagct tgctttatat 1292641 acgcttgccc atcgcgacat agcggttgtt tctgagcact ttatccattc tggaacatgg 1292701 aagctgatat tctggggtgt cttagcagca atcgcggttt gcggctggtt tatgtcaggt 1292761 gggaaaaaac agccggaggg tgcacaaaac gaacaaaaaa acagcacccg tgaacgggcg 1292821 taatctgaaa gactctgctt aaaagcagag tctttttgtg tttgaagcgt tttcataagc 1292881 gaaataaaat aacattttta taacatcttt gttacaaaaa acacgcataa aaccccctta 1292941 attctttaga aaggcacgaa atcatgtata gaacgtcaga atggtttgtc ataattgaga 1293001 cattggaaat caatatttct ttttctcctt tgcgaatccc tatcaaatta gctatcatta 1293061 atgagtagtt atagggagga actgaggtga aaccagtgct tagccttttg tttaaattgg 1293121 gaaaaaagaa gcaaacactt gaaaaagctg ttgagagtat acaaaaaggc aataaagatc 1293181 tgcaaaatga attaatacag caatataagc catttatcgc aaagacggtt tcatccgttt 1293241 gtaaacgata tatagatgaa aaagacgatg agttcagtat tggactgatc gcgtttaatg 1293301 aagctataga aaaatattca cctgaaaaag gaaattctct gctcgcattt gctgagctta 1293361 ttataaaaag aaaagtcatt gattacatta gaaaagaagc cagaagcgca caaaatataa 1293421 atatcgattt acaggaagga gacgatcagg agtcatcaca aagcctgatt gaagccgagc 1293481 tttccattga tgaataccgc cgtcagattg aacaggagca gaggcgggag gaaatcctct 1293541 attttcaaaa gcagctcaag gattatggtt tatcgtttaa agaactgctt gaaaattctc 1293601 caaaacacac ggatgcaagg caaaacgcca taaaggtggc aatgacgctt gttgaacatg 1293661 aagaattggc cgctatcctg tatacaaaga agcagcttcc ggtcaaacag cttgaacagc 1293721 ttgtctctgt aagccgaaaa acgattgaga gaaacagaaa atatattatt gcgatgtgta 1293781 ttatcattac gggtgattat atttatttaa aagattatct taaaggggtg ctgcactcat 1293841 gagaagaggg attatagtag agaaaaataa aaaattcgtc acgttgctga cccctgacgg 1293901 acaattttta aaagccaaaa atgatcgaca cagctatgaa atcggagaag aaatcatgct 1293961 tccgagtgaa acacgcatgg gcagaagggc cagctttttt gattttttta aactgcgccc 1294021 tttcaaaatg gggattttta cgatgactgc tattatgctc tttattttta tagttctccc 1294081 cgttttttct aataataagg cctatgcgta tatgacaatc gatatcaatc caagcgtcga 1294141 aatggcgtta aacagcgatt atgaagtgat tgaactgacg cctctaaacg atgagggaca 1294201 gaaagtcgtg aatgatatag atgattggga gaagactgat tttaaaaagg tgattgacga 1294261 tattataacc gactgcagtg aacacgggta tgtaaaaaaa tcgaaagaaa tattgatttc 1294321 cactgtttat gaaaacacag aagacaatac atataaaaag gctgtgaaaa aacagctgaa 1294381 tgatgtgact gaaaaatata aaacgacata ccgcatggaa tctctcgagt cagatatgca 1294441 aacgagggaa aaagcgaaga aagaaggcgt ctcaacaggc agctacatca aatcaaatga 1294501 aaagaatgac aataaagata taaaagatga ctccagcaaa ccatccgggg aagaggatca 1294561 aaagagtgat gaaaatgagg atgaaaacac cgatcaaact gacacccagg acagcaagca 1294621 aggagataat gaacagctga atgatgcgga ttccggagac cagaaagaag agaaagcgga 1294681 tgaccagatt gatgatagtg acaaagataa aaaaataaag gaatcagatg aaaacacaaa 1294741 taccgaaaaa gatggggacc atgagcaaac cccaatacaa gatcctcaag ataaaggaaa 1294801 tgaaaataac ggcgctgaca agggccaaag ccaatatcac agggactgga acaatggtga 1294861 acaaggcaag aaccgttctt cgtccagaag ggataacgct tcagaccgac gtaatccaaa 1294921 cggctacagc agtgataatc attcagctaa aaatgaagat tcgccgagtg cccccggcga 1294981 ataaagacct gaatttattt agttgtgcca tttaattgtg attgtgcttg ctgtaccagc 1295041 cgctttgtca tttctccgcc tacagagccg ttagcgcgtg cgactgtatc agaaccaagg 1295101 ttcacaccga attcttgagc cacttcgagt ttaaattggt ctagtgcctg ctccacccct 1295161 ggaacaacga gtttatttct gctcgccatc tttttcatct cctttttcga taaagaaatt 1295221 cttaacgcgt atttagtttg aaatatacgg ggtttattta tgctggcaat tgttgtggag 1295281 aaaaataaaa ccccggcctc tgagccgggg tggcgcagac tatagaatgt ctgctgtcat 1295341 tttatgtgcg gttgcctgaa tatggaatgt caaaatggag aggactgtaa tggcgataat 1295401 ctgtctgatt ttaagccatt ggctgtcatt cagttcttca aaacggtgac ggagacgctc 1295461 tgtctcctgt tcggcgatct cctgcagatt tgattctttc atagaaggag tatcttggtg 1295521 atggatggca tcaagcacat atgcgcagct ttcataataa gcaatcgggc tgatgacatc 1295581 atcagatctg tctgagattg tgttaaaggc cacttttaaa atagcccgta tgtgttcaaa 1295641 gtcataaatg gattttaaat cacgtacaat taaaagaata actgcctgtt caattgagta 1295701 ttttttgccc agctcagggt gtccgatcag atctttgata tcacgcttta cccagttttg 1295761 aatcgcggtt gactttaacg aagtcagctc gcataagttg ccaagctcta cgatttcatt 1295821 tgtagacaga ccgtattctt ttttctgttt ttttcgttcg tatcttgtaa gaaattcagg 1295881 aatttctaga tgattggctg ctttttctgc tgacatgttc gctgattgga cgagaatgtc 1295941 gagcgggcta tgttctcctt gtccttttag ggaatagagc agccgcacca tatcggttcg 1296001 agagagttta aaaatgttca ttgttcacct ctttaaacaa tttgacgcgg atataggtct 1296061 atgtataagt tcaaaattca agcgtcagca aattacatta acatcatacg tcgaattcct 1296121 tgcattttca aatggatgtt ttataattta aatatacggg ttcttttgaa cttaaaataa 1296181 cggaggttgt tatggcgaaa agaatttttc tgtttattct aacgaatatt ttggtgctta 1296241 caacaatcgg gatcgttttg tctgttttaa gctctgttac aggagtcggg acgtacttta 1296301 cagctgatgg cggtatcgat ccaatggcgc ttcttgtgtt cagtttagtc gttggatttg 1296361 tcggttcctt tacgtctctt gcgatatcca gatggatggc aaagacgatg atgggcgtca 1296421 gagtgctgaa tccgaaaaaa cactcgctca gctatgagga acagcaattg gttgatcgtg 1296481 ttcacagatt aagccgctct gccggtttaa cgaaaatgcc ggaagtcggg atttaccgtt 1296541 cacctgaagt aaacgcgttt gcgactggac cgtcaaaacg ccgttcactt gtcgcagtat 1296601 cgtcagggct gctggagcag atggatgacg cagcagttga aggtgtgctt gcccacgagg 1296661 tcgcgcatat cacaaatggt gatatggtaa caatgacgct tttacaaggt atcgttaata 1296721 cctttgtcgt ctttttatcg cgtatcgccg cttggatagc aagccgtttt gtcaaagaag 1296781 atctagcgcc gatcgttcat tttattgcaa tgattatttt tcagattgtc ttttcgatac 1296841 ttggcagcct ggttgtgttt gcgtattcac gccatcgtga attccatgct gacaggggag 1296901 gagcggatct tgccggcaag gacaagatga ttcatgcgct gcggacgctt aaaagctatt 1296961 cttcccggat tttggaagac gatcagacag ctgtccaaac gttaaagatt aatggcaaga 1297021 agcgctcttc acttttctct actcatcctg atttagatga gcgaatcaga cggctggaag 1297081 ctaaataata caaacacatt gttcctctga gagaattctc agaggttttt tattttatcc 1297141 attgactaaa atcataaaaa aataagcaag ttaagaaaat gtttcgtaaa agcctttaaa 1297201 aatggaccta atatctttag aataattacc gtacttaaaa agagaggcag aaggatttta 1297261 catgagatta aagtttggaa aattgataca ggccttgtca ccggcccagc tgatcgcatt 1297321 atattatttt cttgcagtta ctgtggccgt tatattgctg agtttgccgg cggcccataa 1297381 accgggggcg gattggacgt ttattgatgc gctttttaca gctgtcagtt cagtcagtgt 1297441 aacggggctg acagttgttg atacagctga tacattcagc acaataggga tttttatatt 1297501 agcatttgtt ctgcaatttg gcggaatcgg aattatgacg ctcggaacgt tcatttggct 1297561 gatcatggga aaacgaatcg ggctgaaaga acggaagctg attatggttg atcaaaacca 1297621 atcccagttt tcaggaattg tcaatctgat gaagcaggta ctgtttctga tcttgtggat 1297681 tgaatttttt ggcgggctga tactcggcac atatttctta acctactatg actcctatca 1297741 ggaagcctat ttacacggat tttttgccag tatcagtgca acgacaaacg gcggatttga 1297801 tattaccggt aattcgatga ttccatttcg ccacgattac tttgtgcagt ttattacaat 1297861 gcttttaatt atatttggag cgattggatt tcccgtgctt gttgaagtaa aggatttcct 1297921 gttttcaaag catcggcgtt atccatttac gctttttaca aagatcacga cgattacgtt 1297981 cggctcactt gtcttgtttg gagccattgg catctttgcc ctggaagcaa accatgcgtt 1298041 cgcaggaaaa tcatggcatg atattttgtt tttgtccctg tttcaatcaa cggcaacccg 1298101 aagcgggggg ctggcaacaa tcgatatcag ccaattatca gattccacac tcttttttat 1298161 ttgtgcgctg atgtttattg gagcgtcgcc aagctcagtc gggggaggca taaggacaac 1298221 gacttttgct ttgaaccttc ttgcgctgtt tcattttgcc cgcggcaata aggccgtaaa 1298281 ggtattcaaa cgggagcttc accctgctga cttgatgaag tcgcttgttg tcacgatgat 1298341 ggcgatcctg ctcgtttttg gcgcgacact cattctgacc attacagaaa aacattccct 1298401 gctggagctt ttgtttgaag tgtgctcggc attcggtaca accggcctat cgcttggaat 1298461 tacggcagat ttgagcagtg ttggaaaatg cgtcattatg attgtcatgt ttatcgggcg 1298521 aatcggcatc ttgaccttcc tgtatctgat cggaagaaag gaaattgaag cgaattatca 1298581 ctatccgaag gaaagagtga ttatcggata ggcaaaacac cgcatatttt gcggtgtttt 1298641 ttgattacca aaaaaaagat gtgtgcctcc tgttcagttg gagaacctaa ctccgacagg 1298701 tgcaatttac gctcctgcat cttaaaatgt ctgaaaattg gcgaggagga ttcgtatgaa 1298761 gcgtaaagct gaagtgaatg aagccattaa aaataacaat acacctaccg agagcatgga 1298821 ccccaattca tataagacac aatatcatga cgaccccaat tttagagggg caaaccgcaa 1298881 ttccaaacag ggccagcagg gaggcatgta attgtgaaga aaaaccgtca tagcagagac 1298941 atgcaaaatc ataaaaagcc tatgaataaa aaggtgctgg aggaagaatt ctcaagtgaa 1299001 ctcggggatt acaatgccgg aaagatcatc gaaacgctgg aagtcaccaa gcctgaaaag 1299061 aaaaaagaaa aaaacaaaaa acaacaataa aaaagacctc ttaggcggcg tcccgcttaa 1299121 gaggtgcttt ttctatttta aataagcatt tttgcccgtt cctctgacaa attgcaataa 1299181 gcttgtcatc ctcagctcaa tgaatggctg agcgactgtc ttaacaaagt tgctggagag 1299241 gactgatgtc agggctgctg ttaaaagcaa gaggatcact aagctttgat agtcagtaag 1299301 ccaatcctca agcccgacct gccgtaatgt cttaataata aacccgtgaa gcagatacac 1299361 gtaaaatgtc cgggttcccc atttggtaaa gaaataccgt ttttgcggaa cgagcgctaa 1299421 aaagctgaag gttgccccaa aggcgagtac ataccagccg attcgggata gtccgcttac 1299481 cagggtaacg tctccaaatg aagaatacgg ttttgaacca aacagaaaag aatagtcaaa 1299541 atcgatgccc cagcagatga cgaatactgc ggcaagcact ccgagcgcaa tttgtttgcc 1299601 gcgttttgat ctcaataaat caaaatgatg tttatttaaa taaaaaccga caaggaacat 1299661 cggtaagaat acgaatgtcc gtgacaagct cagcgtgctg ctgacaaagt ccagataacc 1299721 gatcagcacg gcgattccgc agctgacaaa cagcgcccac tgctttgaaa gctttgaaaa 1299781 aggatatagg agcaggttcc aaaagaataa gcttacaaga aaccataacg accattgcgg 1299841 atcaatcggg ttcacatttg ccatgctttc atcttgcata atgtaataaa agacggaata 1299901 aataatttgg aaaatcaaat acggaataat cagcttgacc gccagctttt ttacatatcc 1299961 cgcccgttta aagcctttcg cgaaataacc ggatacaaga ataaatgcag gcatatggaa 1300021 tgtgtaaatg aacttgtaga ggtagagcat aaaatgatta tcattaataa aggaacgaag 1300081 gatatgaccg aatacaacaa ggaatatcaa taaaaatttt gcgttatcga aataactgtc 1300141 ccgcgattta ctcatagcat caccttctct ttcatcagtc actaagagat tattccctgc 1300201 tggtacatat tttaaaataa aagatgaaaa aggaatctaa aaaaatgctg attgttaggt 1300261 cgatgtaaag tgacggtaag gatcgtagaa aatgtcttcg taatgtaatg acgctgaaat 1300321 tttctgaaat ttatagggca aatgaaggaa gttcccgcat tttgtagaaa tattgaggga 1300381 taggttttga agaaggagtg tacatgcatg gaaactcttg gtgtccagac aaactcggag 1300441 ctgcgagagg aactgaatcg cctcaaagaa gaaaacgcgc gactgaaaaa ggaattgaat 1300501 cagcatcaag tgattgtcaa caatacgctc gatgctattt ttatttgtga taacgaaatg 1300561 cggattgttc aggcaaatga agcaacagaa aggatgcttc aagttgactc ggaagatttg 1300621 aaaaagcgtt ctgttttgga ttttttgttt tcaatcccaa aggatgaact gaatctttcc 1300681 gtaaagaagt tttttaaaaa aggctttctg tggaaggagg ttccgatcag gcttgattgc 1300741 ggggcaacaa aatacataga gtttctggcc aaaagaggta ttggtgagga tttctttttt 1300801 gttgtcatga gggacatatc ttctaagaag attctggagc gggaattctc tatgaatgaa 1300861 cagcttttta aggacttgtt tgacagagca gttgacggaa tcgtcctgtt tgataaagat 1300921 ggcggtttta ttgatgcaaa tttgtccttt tgtaaaagct ttgaaatcaa tcataatgag 1300981 ctgtctcatt tatctttgta tgagttcata gacagcggct cacgaaaaga tttcgacaat 1301041 atctggaagg cgctcaaccg caagggaaaa gcgaaggggg agctgcctgt caagcttcgt 1301101 tcaggagttc aaaaactatt tgaattcacg attacatcaa acatcatcag cggtttttat 1301161 atgtccatta tgagggatat cacagagaag cggtctatgg agctgcagct ctttaaaagt 1301221 gaggagcgct tcagagaaat ctttgaaaat gcaatggacg ccatcatcat ctggtcgaat 1301281 gacggaagaa tcgtaaaagc gaatcaatca gcctgtaaaa tttttgagct gccgatgaat 1301341 ttgctgttga aaagaaagct gtgtgatttt ctcgttgact cgcagcagaa atacagcata 1301401 acgaagagga aatacgcaaa atacggagag atcagagaag agctgctgtt tcaaatgggg 1301461 aacggccaat tcaaagagct tgaatttact tcaaaacgga caatccttga aaatcagcat 1301521 ttgacgatct taagaaatgt aagcgacaga aagcggatgg aaaaggagct tcgggaaagc 1301581 gagctgaaat tcagaaaagt gttcaacgga tcaatggacg gcaatgtatt gttcgacaat 1301641 caatacagga tcatcgacgc caacccgtta gcaagccata ttttgggcct gtcacatgaa 1301701 gagatcaaac agcacagcct gttagatatt atttctgctt atgaaataga aaatttggca 1301761 tcaccggcaa ggcagattaa ttttgatgaa atggacaacg aaattccatt tttgctgagc 1301821 agcggtgata acagaaaact cgaattctca tttaaacgga atattattca aaatatgaac 1301881 ttggctatct ttaaagacgt aacagagcga aaagaattgg aggagcgcct gcgcaaatca 1301941 gatacccttc atgttgtcgg cgaactcgca gccggtattg ctcatgaaat cagaaatccg 1302001 atgactgctc ttaaaggctt cattcagctt ctgaaaggga gtgtcgaggg agactacgcc 1302061 ctttacttca acgtgatcac ctcagaacta aagcgcatcg aatccatcat caccgaattc 1302121 ttgattttag ccaagcccca ggccattatg tatgaggaaa aacatgttac ccaaattatg 1302181 agggacacga tagaccttct aaatgcgcaa gccaatctca gcaatgtaca aatgcaactt 1302241 gatttaattg acgacattcc cccgatttac tgtgaaccga atcagctgaa acaggttttt 1302301 atcaatatat taaaaaacgc catcgaagtg atgcctgacg gcggaaatat ttttgtaacg 1302361 ataaaggcat tggatcaaga tcatgttcta atctccttaa aagacgaggg aatcggaatg 1302421 acagaagata aattaaagcg acttggtgaa ccgttttata cgacaaagga acggggaact 1302481 ggacttgggc ttatggtaag ctataaaatt attgaagaac atcaaggcga gattatggta 1302541 gaaagtgaag aagggaaggg caccgttttc catattacgc ttcctgtcag acagaatgct 1302601 gaagaaagaa ggaatgatga atgaactact atacgacagc cgaaacgccg ctcggtgaac 1302661 ttatcattgc cgaagaggag gaccggatca ctcgtctatt tctcagtcag gaagattggg 1302721 tggattggaa agaaacggtt cagaatactg agcataagga aacacctaat cttgcagaag 1302781 cgaaacaaca gcttcaagaa tatttcgcag gcgaaaggaa gacattctcc ctgccgctca 1302841 gccaaaaggg cactcctttt cagcaaaaag tgtggcaagc gctggagagg attccatatg 1302901 gcgaatcccg aagctatgcg gatattgccg ctgctgtcgg cagtccgaaa gcggtgcgcg 1302961 ctgtcgggca ggctaataaa cgtaacgacc tgccgatttt tgtcccgtgc cacagagtga 1303021 tcggcaaaaa cagtgcgtta acaggatacg ccggaagcaa aacggagatc aaagcatttt 1303081 tgctaaacat cgagcgaatc tcctataaag aaaaataaaa catatggcac gttccctttt 1303141 ttcacggccg acatatcatt ttattaagtt aaaaaagttg gtctgatgaa aaaggaggac 1303201 aaagcaattg aagccgagcc gctctgagaa acttgccgtt tttgccgaac tgtttgtgaa 1303261 actgcatatc ttatcaagcg ctcaaaaaga tgaaatcatc aatgttaaca aaaagaaaca 1303321 aaaaaaccgc tgactcggct ccaaatgagc aaagtccagc ggttttttaa tgcacctttt 1303381 ctcctttaaa cagctgttca atctcttctt catagtttcc ggtcataatc cctttttctg 1303441 tgatgattcc tgaaatgaga tcatgaggtg taatgtcgaa agcgggatta aagacaggca 1303501 cattggatgg agcggtccga actccggaaa tctgcctgac ttcctcggga tctcgttcct 1303561 ctatcgggat atcagcgccg catttgacct ttgtatcaaa tgtagataaa ggtgcggcga 1303621 caaaaaacgg aatatcaaag gcgtttgcta aaatagcaag accgtatgtg ccgattttat 1303681 ttgccgtatc accgttcttt gcaattcggt cggctccgac gataacagcg gaaatttgtt 1303741 tttccttcat cgtatgggcg gccatgctgt ctgtgatcag agtgacatca atgcccccct 1303801 gcatcagctc ccaagcagta aggcgtgaac cttgcaggac aggccttgtt tcacaggcat 1303861 aaatgtgtaa tcccaaatct ttttgtttgg ccaagtaaaa cggagctagc gccgttccat 1303921 agcggcttgt cgcgattgag ccggcattgc agatcgtcat gatcctgtcg ccttttttga 1303981 aaagctgcag ggcgttttgg ccgatcaacc ggcacgtttc ctcatcctcg acctgaatct 1304041 gaatggcttc atggacaagg tttgtttttg cttcatttac ggaaatcgcg ttttcgaccg 1304101 aatgactcag tctctcaagc gcccatgaca aattaatggc ggtaggccgt gagctgttta 1304161 aatattgttt gatgtcttcc agtctgcggc ggaattccgt gacattgtct gtttcaatgt 1304221 ctttggcagc aagcgccagt ccgaaggcag ctgtaatgcc gatcgccgga gcgcccctta 1304281 ctttgagcgt gacaatcgca tcaaatacat cctctttcgt cgtcagctcc aaatattccg 1304341 tctcatcagg aagcttttgc tgatttaaaa tggtaatagc tgtttctttc cattcaacag 1304401 aacgtggaac agcaaatgaa tgggtcatga atagatcatt cctttacaag taacttaaat 1304461 aattcaataa catctgttat cgttttgaat tccgaacgtt tttcgataaa ggctgtgccg 1304521 gtttcgagcg ccaagcgttt tctgccgatt cgtttatcaa acggcacgat cgtatccagg 1304581 tcagctacat gggcaaggcc gatcgtgcgt cgtatcagct cacagcccgc aaatccgatt 1304641 gcttcttcaa aaatatggct gagcgtatca gtgaggtaac cgtcgatgtt ggcgtaaaca 1304701 tccagactgt ccttctgcca ggcttcacta aacgtctctt caaacgtttc ccagacctgg 1304761 ttgacatgtt catataacgg ctctctgtca gccccgtcac ggctgagtgc gttcaaaaat 1304821 aagttggcga taaattgccc tacatcaaag ccgatcggtc cgtaaaaagc aaactcagga 1304881 tcaatcacct ttgtttcgtg ctcacttgcg aaaatgcttc ctgtatgcaa atcaccatga 1304941 atcaacgttt ctgcagacgt taaaaatgac tttttcagct tagcggcttc gattttaacg 1305001 ctgtcattat tccaaagctt ttcgacaaaa ggacgaagct cttcttcaaa atcatttgtg 1305061 tcatggtcga agaaaggatc tgtaaaaaca agtctttccg taatgtcgca tagctctgga 1305121 tttgtaaact gtttaacaag ctgttttttc accttaggtt caagcgcgta atctgatgag 1305181 tagaaaagtg tttttcctaa aaattcaccg atgtgctgcg acagatgagg atagttttca 1305241 ccctcaatga gtccttttct tgcgatcttg aggtgagaga gatcctccat gacggtaacc 1305301 gccatttccg tatcagaata aaacactctt ggaaccaggt gaggcacatg ctcgccctga 1305361 cggatgagag cgctgctttc gattcttgca cggtcgattg tcagcggcca gctttctccc 1305421 accacttttg catacggaac cgcctgttta atgatcaatg ctctgtcatg ttcttgatca 1305481 taaatatgaa aaacgtaatt taagttgccg tctccgatct cctggcatgt cagcgtgctt 1305541 ttgcttggaa ataggccaag cttcaccgcc aacgccacag cggagctttc atttaacgtt 1305601 tcgtataaag gtgtttttgt gactcccatc atcataacct ccaattatgt aattaattaa 1305661 tatgtggccg taaaaaagcc tccttctcag agagaaggag gcttaacatc tatgtccgcc 1305721 tctcttatct ctcagatcag atctgaatgg aattagcacc gtgccttaag agaccagcgt 1305781 ctcggcgcga aaaaaatgcg ccccatttca caatggaatt acggtcggtt gcttttgggg 1305841 tcaaaaggcc aaatccctcg cccaactctc gataagagaa tatattcact tgtttgacaa 1305901 ttctaattta tcagttgatg aacatggtaa caggtaattt agttagttgt caatatattt 1305961 tttaatataa atcttttctg atatcatcga aaacaggaat gctctcccga acttctgcgc 1306021 tttcttgaag gtcgatttcc gctcggacta tgccttcttc ccggccgcct tcagcaagta 1306081 cacgtcccca tggatcaata atcaggctat gtcctgcaaa ttcattatcc ggatttgaac 1306141 cggtacaatt gcaggctgcg acaaagcatt ggttttcaat ggcccgcgca ataagcaggc 1306201 ttttccaatg atcaaggcgg ggaagaggcc attccgcaga aataaacagc acgttggcgc 1306261 cttttgtcgt atgttttctg atccattccg gaaaacggat atcgtaacag atcaatccag 1306321 agcttttgac gccgtcaagc tcaaagtatc cgtcttcgga accggctgat aaatacagat 1306381 gctcatccat cagctgaaaa agatgggctt ttctgtactc tttaatgatt tgcccttcct 1306441 tatccgcgat gtacattgta ttataaacat cagaattctt cctgacagcg accgatccgg 1306501 cgacaatatg aacaccatgt ttttttgccg ttttcttcag ccagctctga gcggagcggc 1306561 cgtcttcgtc agcgagttca tcaagattgg ccagatcata tccggtcgtc cataattcag 1306621 gcagaacaag aacatcagca tgtttgcttt ctttttcgat gaaaaattca gcctttttta 1306681 tattttccga aggttttccg tatgaaatat caaattgaag acaagatatc gtccatttca 1306741 tctttttaac accccaaatt tttctttact tttttcattt aaccatatat gatgatggac 1306801 tatcatttca agattttttt agaaggtgag aatagatgaa atttgaacag tctcatgtat 1306861 tgaaggaatt gcctaaacaa ttcttcgctt ctctggtgca gaaagtgaac cgaaagcttg 1306921 cagaaggaca tgacgttatc aatctgggac agggaaatcc agatcagccg actcctgagc 1306981 atattgttga ggagatgaaa cgagctgtcg ctgatcctga gaatcataaa tattcgtctt 1307041 ttcgcggctc ataccgtctg aagtcagcgg ctgctgcatt ttacaaaaga gaatacggca 1307101 ttgatctgga tccggaaacc gaagtcgctg tattattcgg cggaaaagcc ggtctagtcg 1307161 agctcccgca atgcttgttg aatcccggtg atacgatttt agttcccgat ccgggttatc 1307221 ctgattactg gtcgggtgtc acacttgcaa aagcaaagat ggaaatgatg ccgctcgtaa 1307281 aggacagagc gtttctccct gattacagca gcataaccgc tgaaataagg gaacaggcga 1307341 aattgatgta tttgaattat ccgaataatc cgactggagc tgttgctact tccgagttct 1307401 ttgaagatac cgtgcgtttt gcggctgaaa acggaatctg cgtcgttcac gattttgctt 1307461 acggcgctgt aggatttgac ggctgcaagc ctttaagctt tttgcagact gaaggtgcga 1307521 aggatatcgg aattgaaatt tacacgctgt caaaaacgta taatatggca ggatggcggg 1307581 ttggctttgc cgtcggaaac gcttcggtca ttgaagcgat caatctttat caagaccata 1307641 tgtttgtcag tcttttcaga gcgactcagg aggctgcagc agaggcactg ttagccgatc 1307701 agacgtgtgt ggcagagcaa aatgccaggt atgagagcag gagaaacgct tggatcacgg 1307761 catgccggga aatcggctgg gatgtaacag ctcccgcagg ttcttttttt gcatggctgc 1307821 ctgtgcctga aggctatact tctgagcagt tctcagatct tttgctggaa aaagcgaatg 1307881 tggcagttgc ggctggaaac ggcttcggtg aatatggcga gggctacgtc agagtcggac 1307941 ttttaacaag tgaagaaaga cttaaggaag ccgcttatcg aattggcaaa ctgaacctgt 1308001 ttacccaaaa aagcattgac aagaccttat aacgatggga taattcaaaa taatttataa 1308061 aatctatatt ttcttatcaa gagcaggcag agggacgagc ccgatgaagc ccggcaaccg 1308121 acttataaag cacggtgcta attcttgcag ctagcggctg agagataaga ttcggacgag 1308181 aaacgaaacc tctttagacg cgattgcagt ttgaagaggt tttttgatat ggatgaaaat 1308241 gaaaggagct ctggcatgag tgagttatta gcgacatatc tcctgaccga accgggagcc 1308301 gatacagaga agaaagcaga acaaatcgca acaggattga cagtaggctc ctggactgat 1308361 ctgccccttg taaaacagga gcaaatgcaa aagcacaagg ggcgggtgat aaaagttgag 1308421 gagagagagg gaactgctgc atcagaaaaa caagcggtca tcacaattgc ctatcctgaa 1308481 atcaatttct ctcaggatat tccggctttg ctgacaacag tgtttggcaa gctgtccctg 1308541 gacggaaaaa tcaaattaat cgatcttcac ttctctgaag catttaagcg tgcactgccg 1308601 ggaccgaagt ttggcgtata cggcatccgg aagctgctgg gagagtttga gagaccgctg 1308661 ttaatgagca tatttaaagg cgtaatcgga agggacctga gtgatattaa agaacagctc 1308721 cggcagcagg cgcttggcgg agttgacttg attaaagacg atgaaatttt ctttgagact 1308781 ggtctagcgc cttttgaaac aagaattgca gaaggaaagc aaatattgaa agaaacgtat 1308841 gaacaaaccg gacataaaac gctgtatgcg gtgaatttga ccggacgtac ggctgatctg 1308901 aaagacaaag cgagacgcgc cgccgaattg ggagcggatg cgcttttgtt taatgtcttc 1308961 gcttacggct tggacgttat gcaaggcctt gcagaagatc ctgaaatccc agttccgatt 1309021 atggcgcatc cagcagtgag cggagcgttt acgtcttctc cgttttacgg tttttctcac 1309081 gctcttttac tcggaaaatt aaaccgatat tgcggtgctg acttcagcct ctttccgtct 1309141 ccatatggtt cggttgcgct tccaagagca gatgcactgg cgattcatga agaatgtgtg 1309201 agagaggatg cttttaacca aacatttgct gttccgtcag caggcattca tcccggcatg 1309261 gttccgctat taatgcgtga tttcggcata gaccacatta ttaacgccgg aggaggcgta 1309321 catggacatc cgaacggtgc ccaaggcggg gggcgagcgt tcagagctat tattgatgcg 1309381 gtcctagagg cccagccgat tgatgaaaaa gccgaacaat gcaaggatct taagcttgcg 1309441 ctagataaat ggggaaaggc tgaagccgta tgacgactcg aaaacctttt attatttgtg 1309501 attttgacgg aacaatcacg atgaacgaca acattataaa tatcatgaaa acatttgctc 1309561 ccccagagtg gatggcatta aaagacggcg tactttccaa aacgctgtca atcaaggaag 1309621 gtgtcgggcg gatgttcggc cttctgccca gcagtttaaa agaagagatt acaagttttg 1309681 tattggaaga tgcaaaaatc agggaaggct ttcgggaatt tgtagcattt atcaatgagc 1309741 acgagattcc gttttatgtc ataagcggtg gaatggactt ttttgtatat cctttgcttg 1309801 aaggcattgt ggagaaagac cgcatttatt gcaaccatgc ttcatttgac aatgactata 1309861 tccatattga ctggcctcat tcctgcaagg gcacatgcag caatcaatgc gggtgctgta 1309921 agccgtcggt catccatgaa ctttctgaac cgaaccaata tatcatcatg atcggtgatt 1309981 cggttacaga tgtggaggca gcaaagctgt ctgacctatg ctttgcaagg gattatttat 1310041 taaacgaatg ccgggagcaa aacctcaatc atcttccgta tcaagatttt tatgagatca 1310101 gaaaggaaat tgagaatgta aaggaggtac aggaatggct gcaaaacaag aacgctggcg 1310161 agagctcgct gaagtaaaac gggaattggc agagagagat tggtttccgg cgactagcgg 1310221 caatctgtca attaaggtta cagatgagcc tttaacattt ctcgtcactg caagcggaaa 1310281 agataaacgc aaagagacgg ttgaagattt tctgctggtc gatcaaaacg gagagcctgc 1310341 tgaaagcggg cattctctga aaccgtcagc agaaacgctt ttgcatacac atttgtacaa 1310401 taaaaccaat gccggatgct gcctgcatgt ccatacggta aacaataatg tgatttcaga 1310461 gttatacgga gaccaaaaga aaatcacatt caaaggccag gaaattataa aagcactcgg 1310521 cttgtgggaa gagaacgcag aagtgaccgt tccgattata gaaaatccgg cacatatccc 1310581 gacgctagcg gcactgtttg cggaagagat ttcagaagat tcaggagctg ttctgatccg 1310641 aaatcatggt attacggctt gggggaaaac agcatttgag gcaaaaagag tgcttgaagc 1310701 gtatgaattt ttgttcagct accatttgaa attgaaaaca ctcgagcatc agctggttaa 1310761 ataaaaggag gaattgaaat ggctacaatt cgaattcatg atgaggcaaa tacaacgatt 1310821 gaaaatcaag aggaagtggc aagctttctg gacagtcaag aggttattta tgagcaatgg 1310881 gatatcacga ggcttccgga acatctctca gagaaatatg acctgacaga agaagaaaaa 1310941 cagcaaattc ttgatacctt cgaaactgaa attaaagata tctcaacccg ccgcggctat 1311001 aaagcacagg atgttatttc attgtcagac agcaatccga aacttgatga actgcttgaa 1311061 aactttaaaa gagagcatca ccatacagac gatgaggttc gttttattgt aagcggacac 1311121 ggtatttttg tcattcaagg ccaggacggc acgttttttg atgtccgttt aaaccctgga 1311181 gatttaatct ccgtgcctga gaatatccgc cattacttca cgcttcagga ggaccgcaaa 1311241 gttgtcgcgg tgagaatttt tgtcacaact gaaggctggg ttcctattta tgaaaaagac 1311301 agcgtgaatc aataagcgtg agatagcccc gttcatcgaa cggggctttt tatatttatt 1311361 gcaaacgcca cttttcatat tgtgacagtt cttttttaat cagtgtccaa atcaaaccta 1311421 aaacagctgc atcgtcaatg aatccaagac cgaggattac gtctggaatg atatcgagcg 1311481 gcatgacgat atacaggatt gcggcagtta acagcaaaag tgttttaacc tgtgaacgag 1311541 ggtagtcgcc atttcgccaa tcgcgaagca tctgaaaaaa agtagtgatg tgctggatac 1311601 atttttttcg gtttttcctc tttaaaatcg cttttccgcc tgccgctccg agcattattg 1311661 ctttcttttt cttcattggg catacctcct gcctggcggc gtgtttaaga tattcttcac 1311721 ctgggtattg ttcttctaat cctatcaata tatctattat acctgaaaaa ttaacttatt 1311781 taatgaaaat atgtttacaa ataaagtata atctgtaata atgcacaata acccaatcaa 1311841 acttgtttcc tatttcttag cggcgagggg tgaagtgaat gggcggttct tctgaacaag 1311901 aaagattgtt ggtgtctatt gatgaaaaaa gaaagttaat gatagatgcc gctagaaagc 1311961 agggatttac agggcatgac acgatcaggc acagtcagga gctggattgt ttaataaatg 1312021 aatatcatca gcttatgcaa gaaaacgaac attcccaagg gattcaaggc cttgtaaaga 1312081 aattaggctt gtggccccgc agagatgtta tgccagcata tgatgcaaat aaatagcggc 1312141 ctatcagatg catatataaa gagagagctt ttcggaagcg ctcttttttt ctggaaaaaa 1312201 ttcatatgaa agagggaact aatgaaggaa ctggcgattc tcattaccga aatggtcaat 1312261 caatttcatg atgcttttat ttccttatgc ggaatatttg gcattcattt aactgacaaa 1312321 gaaatgcatt tttgggtgat cggcattttt ggcatattct ttttcggcgt cactcacgct 1312381 gtgtttacat ggctttctaa atggagtatg acagccttgt cctttatcta taccgttaca 1312441 gtcatcattg tcatcgtatt tgcgattgag attcagcaaa aggtgacggg gagagggaat 1312501 atggagtttt tagatgccac ggaaggtata aagggttttt tagtattttt tatgtttttt 1312561 ttgcttttga aaatgctgtt gcgtttcatc aaaatccttt tttctggaag accagcaagc 1312621 aaatcgaatg gcaatgcccg atcacgaaga taaaaaaccc tcctgacatg gtcagggggg 1312681 ctatgatgcg gatacgggga gggtgatcgt cacctctgtg cctcttcgca cttcactttc 1312741 aatatgaata gagcctccgt acatcagcac gatccgttta caaacaacaa ggccgagacc 1312801 ggttcctttt tctttagaag taacaaaggg aaggaagatg tgatccagca tttcctgaga 1312861 aatcccttca ccgttatcca caactttgat tatggctttt ttatctaaag ctcctaggga 1312921 gatcgtcagt ttgcctcctt caggcattga ctcgaggcca ttttttgcta catttaaaat 1312981 cacttgttta atatgatctt ttgtacattt tacgagtaag ggctgctcgg ttagatactg 1313041 taattcgact tcaacattgt atagattgcc ctcagaataa atgatcggca taatttctcc 1313101 gataatgtcc tgaagtgagt tcagctccca tttttcagct gtcggcttgc cgagaacgag 1313161 aaactcactc actatttgat tgatgcgctt tatctcctgt tcgataatgg agaagtaaag 1313221 ctgatcttcc tcacctttat atttcttttg caacagctga ataaagccgc ttatcccggt 1313281 gagggggtta cggatttcat gggctgtgct ggcagcaagc gtcccgatca gctctaattt 1313341 ttgcgcctcg ttttctgagc gctccagctg ggtctgccgc ttcagcaaat aatacagcac 1313401 gagaataaaa aggatattca gcagaacaat aatacatgaa agcggaagca caaggctttt 1313461 cgacagttct tctattgtga ccgggttcgg atagactttc atattccagc tgatatcatc 1313521 cagatatccg ctgacaggtt tctgatcctc tgcatgagag gcttgtccgc tcgcaaaaat 1313581 cattttcccg tcttggttca caacttcaat ataaacatca gggcttagta agttaatgag 1313641 atttttcaaa taatcaattt gaatagctgc gacaagataa tctgtcacat tacgttttga 1313701 gtccaaaaca ggcacacaaa ttgtgaaaat tggctgacca gtaattctgc tcgaataact 1313761 atctgaaatg actgtctttt tagtttcctt tgcttttata aaaaaagatc tgtcggccag 1313821 gtttactttc gtttttaatt cggttgtgct tgcggtgacg tctcctttgg cattgagaaa 1313881 atagagaccg gaaaatctcg gctctgaatc aaaggtcttt tccaaaattg attgcatttt 1313941 ctttatatca accggtctgt cgatggcgat ggacaaggag gtcattctcg ccattgtttc 1314001 tccgattaaa taattgattt tgttgcggtg aaggtttagc aggacacttg cttcttgttt 1314061 atgttctgca gctattgtat ctttttcttt ttcatatacg aaaaagctga tgacgattgc 1314121 cggaatcacg accagtatga tataaagttt gactctcccg caggcgcctt ttagtatttt 1314181 caatttgcat cgctccaaca tacacctgat tagaggtatt atatcattgt ttcttcttct 1314241 ttaataagaa aaaataacca aaaaaattag aaaaagatgt tggcaagctt acattttaaa 1314301 aaagaagaga aatattggaa agatttttat tgacattttg gtctttgttt attaatgttt 1314361 ctctgtaacg gtttctaaaa ggatgattga gacatgacag aaaaatcact gaagttattt 1314421 atcgtgctgt cgcgcgcgta tcggtctatt aacgatcata tgaataagca tattcataag 1314481 catgggctga atccgactga atttgctgtg ctagagcttt tgtaccataa aggcgatcag 1314541 ccgctgcagc agataggaga taaaattctc ttggctagcg ggagcatcac atacgttgta 1314601 gataagctgg agcaaaaaga acttctcatt cggaaagcgt ctcctacaga cagacgagtg 1314661 acatttgcgc aaattactga aaaaggcatc ggtcttttga acgatatttt ccctgatcac 1314721 gctgctgaaa ttgatgaaat gatcagcgta ttaagcgaag aagaggtaga gatgtgcacc 1314781 gaaatgttaa aaagagtagg attaaacgca aaacagtttc ataataagta aaaaaaggaa 1314841 gcctgatatg tcacaaggct tccttttttg ctatttttca tttgtttccg ctgcgcctct 1314901 cggcaaaatg agaacttcaa cccgccggtt tttgcttcgg ccttccgcag ttttattgga 1314961 agccaccggt ttatactcgc cataaccctt ggcgctgaac acttttgcat cgagcttggg 1315021 gttttcaatc aggagcccca taaagtttac cgctctcatg acgcttaaat gccagtttga 1315081 ttggaattca gaatttttaa ttggcatatt atcagtatgt ccgctgataa tgatatttct 1315141 tggcgggtta atcacaagaa gatttgaaat ctcttttgca agcggcacat cttccttacg 1315201 gatggtcgct tttccagaat cgaagaagat gctgtcttta atcgtaatca gaaggccttc 1315261 actagtcatc ttcgtctcca gctgatgttc cagcttttta tctttgatga acttttccac 1315321 ctggctcttc acattttcaa gttcttcttg atcagctgct ttttcttttt ctttcttgtt 1315381 tttctctttc tcttcttttt cctttttcac ttcatcgatg ccgtctgact cgttttcagg 1315441 aggagtgaca ctggagtagt ccagtacacc ggttccgcct gtaaaaactt cattaaatga 1315501 ttttgagagc atttgaaact tagctgcgtc aatcgagctg ctcgcgtaca gcacaataaa 1315561 caatgccagg agaagagtaa ggatgtcggc gtaaggaacg agccatgatt catcaacgtg 1315621 ctcgtcctca tgcttcttct tcttttttct cgccattttg cgcctctcct tgttctgcaa 1315681 atttcaagcg gtccttcgca ggaagataca ttaaaagctt ttgttcgatg actttcggtg 1315741 cttgtccttc taaaacggat aaaacacctt caatcatgac ctcacgcagt tttacttcct 1315801 gttttgattt tcgttttaat ttatttgcga aaggatgcca taacacatac cctgtaaaga 1315861 taccgagaag tgtggcaaca aaggcagcac tgatggcgtg tccaagctca tctgtgttat 1315921 ccatatgaga gagagcggca atcagcccga ttacagcgcc gagtactcca agtgtcggag 1315981 cgtacgttcc tgcttgtgta aaaatagcgg ctcctgcttg gtgcctgtcc tccattgctt 1316041 cgacttcctc tgtcataata tctcttataa attccgcgct ttgcccgtca acagccatgc 1316101 tgagcccgtt tttcaagaaa gcatcatcta catcctcaat gcttgcttct aaagcaagca 1316161 gaccttcgcg gcgtgcaagc tgagcccatt cagagaacat aggaatgagt tcctctattg 1316221 tgagctgttt attttcctta aataacactc gaaacagcgt aggcactttt ttaatttctt 1316281 ttgttgggaa cgcaataacg actgctgaga ttgtcccggc gataataatt aaaatggcag 1316341 cggggtttgc aagggcgctg aaactgacgc ctttcagaac catcccgacg ctcaatgcca 1316401 caaaagcaag aataataccg attaacgaag ttttatccat agttttcacc aaatcctttt 1316461 ttactagctt gtctatggtt aatatcggtt ttggtgcccg gaactttagg gacattgtga 1316521 atttgttcat gaaatattca aggaagaggc atagaaggga gaaataaaca aaaacgggct 1316581 ctccaaaatt gaaaagcccg ggggtctact gaaattagca gcttgcttgc aagctgtcct 1316641 tcagatggta ttcatataat agtagaaata catattcact gtatataaac atgttccatc 1316701 cctccttaaa aaagtgtaaa ggatgaaggg aagtagcgct tcaggagaag ggacggtaat 1316761 ttctaagtca agagtatgaa agtataaaaa aaagcggctt cctaaaagga aaccgctgat 1316821 tgttattttg ctcgcacttt gattttatca tcttctaaaa tcacgtgaaa acttgtgatc 1316881 tcgccattat caagcagcag atcggtcatt tcatcctcaa cccattcttg gatggttctt 1316941 ctaagcggac gtgcaccgaa tgaagggtgg tagcccagct cagcgatttt ttctttcgct 1317001 tcatctgtca cattcaagct aatgccccgt tccgccaatg tttcttcaag ttctccaaga 1317061 agaaggctga cgattttgac aagatgttct ttttccaatg agcggaactc aataatgctg 1317121 tcaaaacggt tgaggaactc aggtttaaag aacatgctca gtgaatcaat taatgtttgt 1317181 tcttcgatga cactgtcatc tgattggaaa ccgactttcg tttgtttctc accagcaccc 1317241 gcattacttg tcatgatgat cacagtgtct ttgaagctta cagttctgcc ttggctgtct 1317301 gtcagacggc catcttccat aatttgcagg aacatatgct gaacgtctgg gtgtgctttt 1317361 tcaatctcat ccagcaacac aatgctgtaa ggattgcggc gcaccttctc agttaattgt 1317421 ccagcttcct catggccgac atatccaggc ggtgaaccga taattttaga tacggcgtgt 1317481 ttctccatgt attcgctcat atcgagtcgg ataatagcgt cttttgtgcc gaataattca 1317541 tctgccagtg ttttagaaag ctctgttttc cctacgccgg taggaccgac gaagaggaag 1317601 gagccgactg gtctgttttt ggattttaat ccggcgcggc ttcgtcttac cgcttttgcc 1317661 actttttgaa cagcggcttc ttgtccgatc acgcgttcat gaagttttgc ttcgagttct 1317721 ttcattttcg tttgttcgtc tgcctgcagt ttgccgacag ggatgcctgt tttttgttca 1317781 acaatttcct gaatgtgctc agcttccaca gtgacagcgg tatgagcgga ggagctgttc 1317841 agttttttct ccaatgcgag ttcttcatca cggagttttg ccgccagttc gtaattttct 1317901 tcttccaggg cttttgtttt ttcggcttca attgcagtta agcgttcagc ggcatcctca 1317961 tcattcagtt catcaattaa caggttggct tttgaacctg cttcatctaa taaatcaatt 1318021 gctttatccg gcaggtgtct gtcctgaatg tagcgggatg ataaagtgac acatgctttg 1318081 attgcttcat cactgaatgt tacgccatgg tacgcctcgt atttgtcttt aatcccttgc 1318141 agaatgagga tagcctgttc aattgaaggc tcctgcacca tgacaggctg aaaacgtctt 1318201 tccagcgcgg catctttttc gatttgacga tattctttca gtgttgtcgc gccaatgact 1318261 tgcagttcgc ctctggctag ggccggtttg agaatgttgc cggcgtccat tgatccttct 1318321 gcagagcctg cgccgacgag aaggtgaatt tcatcaatga acagaatgac attttttcgt 1318381 tccttcagct cagtgatcag ctgtttcatt ctctcctcaa attggcctct gatccctgtg 1318441 tttgcaacaa gagatgcaac atcaagcaag tatagctctt tgttttttag tttgtttgga 1318501 acatcacctt cagcaatttt taaagcgagc ccttcagcga tggcagtttt ccctacaccc 1318561 ggctcaccaa taagaaccgg attgtttttg tttcggcggt ttagaatttc gatcactcgc 1318621 gccacttcat catcacggcc gatgacggga tcaatgagac cggcttttgc accgtttgta 1318681 atattttgag ccagctcatc aagcaaccct tttttttcgc tttgttttgc tgcgctctgt 1318741 tctttcggct ggaatgcctg ttcaaacgga aatccgaaag attgaggacc catactcatt 1318801 gaaggtttac gggtcagttc gttatagcaa gtttcacaaa gaaccatctg tttatgaacg 1318861 gaatttattt gcatgttaag gcgaatcgtc gcctcgtttt gatgacaatg ttgacaacgc 1318921 atttgccaaa acctccttaa taatttgatc atctttgacc aatgaaagtg aataaaaagg 1318981 tctattgggt ttgaccttct ttgactatta gtatacggca aacttaacgg cattcaaacc 1319041 aatatgctca aagcagactg aatatttgac tatctttgac caattgattt ttaaaaaagg 1319101 ccggtttgtt tgaccaactt tgattaatag tatactctga ctatctttga ctttcaagtc 1319161 ttatgcacaa aaatttttga tttgttacaa agtaaaacat gttttcttcg tcttttcaag 1319221 gaacttgtct cataggttat aaaaaggcat atatggacaa aactgcggtt cgttcggagg 1319281 gaagaaatgg aacaatcaaa agggtctgca agtcagcttg cttttgtgta tgtcggcaca 1319341 gtagtcggag ctggatttgc gactgggagg gaaattgttg agttttttct gaagttcggc 1319401 tggttcggtt ttttcggcat tctcgtcagc ggcggaatgt ttacgttact gggggccaag 1319461 ctgatgatca tttcaaagcg aatcaatgcc aagtcatatc aagaaatgaa catatttttg 1319521 ttcggggcga cggctgggcg gattatcaat gtatttatgc tgtttgttct ccttggagtt 1319581 acatctgtta tgctttcagg ggcaggggcg ctttttgagg aacagctggg gatgtccgct 1319641 cagattggga tgctcattac aatcggtctg agtttaattg tgatgactag aggagtaaaa 1319701 ggcattttcg gtgtcaatgt gtttgttgtt cctcttttaa tcatcttttc aatgattgtg 1319761 gtggccgact cttttatatt cagcgaatca cgaaacgcag ctcagtgggt ctggccgcat 1319821 cgctgggatt ggctgttatc agcagtttct tacggggctt taaatttatc gcttgcccaa 1319881 gctgttttgg ttccgctggc gaatgaaatg tcatcggaga aagtgataaa aaaaggcgct 1319941 ttaatcggag gcacgatgct gacgattgtg ctgtccgcga gttttctgtc tttgtcgact 1320001 cttccggatg tatttttgta tgatataccg atggcgcaag tggtttatct ctttgcacga 1320061 tctgtccatt tgatttattt actcattatt ttcggagaag tgttcacatc agttatcggt 1320121 aatctatatg gattagaaaa acaagtgcaa agctttcttc cagtgaaaag caaatatatc 1320181 tttgcagcca ttatgatcac ggcttatatt acgagccaaa tagggtacgg caggcttatt 1320241 tcaacgattt atcccttgtt tggctatgtg agcctggcct tcataggcgc tttgctttgc 1320301 aaaaaagctc ctcggcggcg cagtttataa atatatataa tgaaacgaac cgtcactata 1320361 gagcgataat tgatctagga accggggact gactttttta ttgtcaagaa aaacatcatt 1320421 atggtaagat agcagaagtg aaaaaattga agaaaatccg tgcgatatgc gggagaggtt 1320481 ctagctacac cctctataaa aaactaagga cgagctgtat ccttggatac ggcctttttt 1320541 atgtttttct agagcacctt ccgaaaaaag gtgttttttt gcgtgaatta gctgtagcga 1320601 tgtctctcgc cggcgttttt attgcggaga aggagaggaa tcatgaaaaa agaaaaagca 1320661 attgtcgtat ttagcggcgg tcaagacagc acaacatgct tactgtgggc cttaaaagaa 1320721 ttcgaagaag tcgaaacggt gacttttcat tataatcagc gacattcgca ggaagttgaa 1320781 gtggcaaaat ccattgcgga aaagcttggt gtgaaaaatc atttgcttga tatgtcactt 1320841 ttaaatcagc ttgcaccgaa tgccctgact agaaatgata ttgagataga agtaaaagac 1320901 ggcgaactgc catccacatt cgttccaggc cgcaatttgg tattcttatc ctttgcgtct 1320961 atcctggctt accaaattgg cgcgcgccac attattacag gagtttgcga gacagacttc 1321021 agtggttatc ctgactgccg tgacgaattc gtgaaatctt gcaatgtcac ggtaaatctg 1321081 gcaatggaga agccgtttgt gatccacacg cctctcatgt ggctcaataa ggcggaaacg 1321141 tggaagcttg cagatgagct tggcgcgctg gattttgtga aaaacaacac gctgacatgc 1321201 tataacggca tcatcgcaga cggctgcggc gaatgtccgg catgtcacct tcgttcaaaa 1321261 ggttatgaag aatatatggt gatgaaagga gagcgtgcat aaattgttat ctcaaattta 1321321 tccgcaggcc cagcatcctt attcgtttga actgaataag gacatgcata tctcagccgc 1321381 tcattttatc cctcgggaaa gtgcgggagc gtgcagcagg gttcacgggc atacgtatac 1321441 cgtaaatata accgttgccg gcgacgaact tgacgattca ggctttcttg tcaatttcag 1321501 cgtactcaaa aaactggtgc acggaaacta tgatcacacg ctattaaatg atcatgaaga 1321561 tttttctcag gacgaccggt attcgctgcc gacaactgaa gtcgtggcga aaacgattta 1321621 tgacaacgta caggcttatt tagacacttt ggagaataag ccgacctgtg tacaggtgtt 1321681 tgtccgtgaa acaccgacaa gctactgtgt ctaccgtccg aaaaagggtg gtttgaatgg 1321741 ctaaaggaat tcctgtatta gaaattttcg gcccgacgat tcaaggagaa ggcatggtga 1321801 tcggacagaa aacgatgttc gtccggacag ccggctgcga ttattcctgc agctggtgtg 1321861 actccgcttt cacttgggac gggtctgcta aaaaagatat tcgctggatg acggcggagg 1321921 agatttttgc ggagcttaag gacattgggg gagatgcgtt ttctcatgtg acgatctcag 1321981 gcggcaaccc ggctctgtta aaacagctgg atgcttttat tgaactgctg aaggaaaata 1322041 acatccgtgc agcgcttgaa actcaaggga ccgtttatca ggattggttt acgctgattg 1322101 atgacctgac aatttctcca aaaccgccaa gctcaaaaat ggtaacgaac tttcaaaagc 1322161 ttgaccacat tttaacttca cttcaagaga atgatagaca gcatgctgtc agcttgaagg 1322221 ttgtcatctt taatgatgaa gatctggaat ttgccaaaac tgtgcacaag cggtatccgg 1322281 gaatcccgtt ttatttacaa gtcggaaatg atgacgtgca tacgacagat gatcagtcac 1322341 tgattgcaca tttgcttgga aaatatgaag cgcttgttga taaggtagct gtcgatgcgg 1322401 agctgaatct cgtcagagtg ctcccgcagc tgcacaccct gttatggggc aacaaacgcg 1322461 gagtataata gaaaggaaga tgaacatgac gacaagaaaa gaatcagaat tagaaggtgt 1322521 aacattgcta ggcaatcaag gtacaaatta tttgttcgaa tatgcaccgg acgtgctgga 1322581 atccttccct aataaacatg taaaccgtga ttactttgta aaattcaatt gcccggaatt 1322641 cacatcttta tgtcctaaaa caggccagcc tgactttgcg acaatctaca tcagctacat 1322701 tcctgatgaa aaaatggttg aaagcaaatc attaaagctg tatctattca gcttcagaaa 1322761 ccatggtgac ttccacgagg actgcatgaa tatcatcatg aacgacttga ttgaattaat 1322821 ggacccgcgc tacattgaag tatggggcaa attcacgcca agaggcggaa tttccattga 1322881 tccgtacaca aactacggaa agcctggcac gaagtatgag aaaatggccg aataccgtat 1322941 gatgaaccat gatttgtatc cggagacaat tgataatcgt taattattcc gttgtgtgat 1323001 acggagtgta aaaggaagtg gagtcacagt aaaatccgaa cattcagcgt taattttcag 1323061 cggaaatgtg acctggtcac agcgaagtgt gacccgcact aagctcaata aaagtgggaa 1323121 aagtcacacc tgaaaatggc tctactcatg ggaattgtat taaaaagtgt gacctgaggt 1323181 gcaacctgaa ctgtgacttt tatgcagtga aaaattgata gtacagaagc agattaaggc 1323241 gtacaatttg tacgtctttt cttttttatc cgaaagaaaa aatgcctatc tagagatcat 1323301 aggcattaaa tattattatc aatatcttca tttatttttt ggctaagttt ctgaaccttc 1323361 tctttaacat ttgaaacagc tcttttttga atttcatcaa ttctcctgaa tatagtcgat 1323421 gacacttctt attagaactt cactttcaaa attgaatatc tcatttattt ctgactgttc 1323481 ttcatctgtt aggtgatggt attgaagttg tttagcattt acttcagcag ctacatcaat 1323541 cctaacttag ttgttctggt tgtacaattt catattcacc ttctgcatac tcttgctccg 1323601 cataatagcc tccccattga cagagctcct gcaagatagg tttaagagat tctccaagtt 1323661 cagtggatga atattcaacc ttcggcggta cttgattata catctttctg ctcacaagtc 1323721 cactggcttc aagctctcta agtgtttgaa tcagcatttt ctgagttata tttgggataa 1323781 tgcgctttaa ttcactcgtt ctctttggtc cattcattaa aaagtataat acaaggcctt 1323841 tccattttcc gccaataact tcctttgtca cttcaaaccc acagctaaat tttttcatgt 1323901 ctaaagctct ccattccaca tttattactt tttagttact atatcacaaa aaagtgggta 1323961 cttccgataa tgtgcttact gaaggatact atatcttgta agttgttctt caagtactta 1324021 aaggtactag acataaaata aaattaattc taaaggagtg ttaagtatgg gtaaatttga 1324081 aggtaaaata gcgcttgtaa cgggtggaac aagtgggatt ggtcttgcta cagcacaaaa 1324141 atttgtaaac gaaggtgcat atgtttatat tacgggacgt agacaaaacg aacttgataa 1324201 agctgttaac caaattggca agaacgtaac cggtgttcaa ggtgatattt ctaagcttga 1324261 agacttagac aaactatatg acattataaa gcaggaaaaa ggtaagttgg acattctttt 1324321 tgctaatgca ggcatcggca acttccttcc attaggtgaa attactgaag agcaggttga 1324381 tagaacgttc gacattaacg ttaaaggaac catctttact gttcaaaaag cgttatcact 1324441 attcccggac aaagtaggtt ctattattgt aacgggctct actgctggat caattggcaa 1324501 cccagcgttt agtgtatatg gagcatctaa agcagcatta agagcactag ttcgcaactg 1324561 gattcttgac ctaaaaggta ctgaaatccg tgtaaatgtg gttagtccag gaggtattct 1324621 tacacctgcc tacgatgagc tttttggtga tgcacttgaa gaggtactgg aaaatagcag 1324681 aaatactgtt ccagctggaa aagttgggac acctgaagaa gtagcaaacg ctgtatcttt 1324741 ccttgcttca gacgaaagca gttacttgac gggtgttgaa ttgttcgtag atggcgggct 1324801 agcacaggta taatttcact gcgcagagat tacaaatagt ccccaaaaaa ggttaatggg 1324861 gatttacttg aagaagtcgt ataaaaaagt cgttttcctt aaaggacagg gaattcgact 1324921 tttttatatt tgaatttgat taacgttgta aattcgcatt ttcctggggc tactactaaa 1324981 tgacctgtaa aaaagattac actgtgaata aatgtactta aagtaacggg ggctcttgac 1325041 ttttaataaa aaataatatc cctgtccttg tattctaata cttttaaaaa tatttaaagg 1325101 aatccttatg tcctgaataa ccacatagga aaatatgttg taggttgctt tctttttttg 1325161 tggggcatcc cacacaagct atctcgtgat ctcacacctg aacgtttttt atagactagt 1325221 accgcgacaa gttatattac atatacatac caataaagta gacattaaaa agtgaaagag 1325281 aggatggaaa tgtgtgaaaa ttcttttcct tgagagtcat cccatgtggc tctatggttt 1325341 accgaatggg tttagggaag caggacatac cgtaatgatt tccggtcctg taagtcggga 1325401 aaatataact gaaatgatag acgaatttaa accagattta atagtatcta tgggatggac 1325461 accagagcat tcaagggaaa agcaggcctg gattcgcaac gctactaaaa aggtgaatat 1325521 ccctctcgtt tattgggcaa ctgaagaccc gctgcacact caaaacttta ctatcccgtt 1325581 aattaaaaag atgaaaccgg attttgtttt cacggtcacg ccttctctgt gtaaaactta 1325641 tgaaagcatg gggattaaag cagctcactt agactttgca tttcacgaaa gtatacatca 1325701 ccagattaaa ccattagcga aatacagttg tgatatagca gtggtggcta atgcttaccc 1325761 taattttctt gaagaacatc cggaagtgtt ccgttcgtcc tctttaaaaa cgcttattcg 1325821 tcctcttata cggaagggta ttcgcattga tttttggggg agaaactggg aaaaaatgag 1325881 taaatatata ggaagagaaa ttccccgcaa ttggatccat ggataccttg attatactga 1325941 agcatataaa gtttacagtt cagcaaaaat cattatcggt ttgcaaaact gtgaaagcca 1326001 acttacacaa cgcacctatg agattcttgg ttccgggggg tttttattga catcggatac 1326061 accagcagtt cgaggtaaat tcaaacctgg ccgcgatctc atcgtttctt cctccccaaa 1326121 agaaacattg gaaaaggtta aatactattt aaatcatgat agcgagagaa aaaagattca 1326181 gataaacggt aaaaaggctg taaagaatga ttcctatcgg catagagccg agagaatgct 1326241 tgaggtgcta aaaagcagag gaatcataag aaacttaggg gaaaccattc attatgtaga 1326301 tgttctcaaa gaaaaatacg tgatccatca tgttactccc ggtgaaacat tatcaataat 1326361 tgccagtaag tataatgttt ccctgcagca actcatggag cttaatcatt tcaaatcaga 1326421 tcaaatatat gctggacaaa tcattaagat tagagagaaa ctgtttagaa atattaataa 1326481 caaattattc taaaggagag taatatgaat gaaggggaaa atacctaaaa taagaaatca 1326541 agcgaataaa gtaaaaagaa cgcctcgtta tatggaattt cccgtgacat acgaagtata 1326601 tcatgtggaa tccggcgata cattatggac gattgccaaa tcctttgaaa ttccggtaca 1326661 acaacttatg aatcttaata agctttcttc agatagaatt tatcctggac aaattataaa 1326721 gataagagaa agataatctt tgaggtttcg gaagcgaatc aaattgaaat gacaatcctc 1326781 atttttttat ttgtggggaa cttgatattt ttggggatga aggggttatg agatgtttca 1326841 aatgagctat tactattctg gattaggatg ggactttatt caacacgttg atcaaacgaa 1326901 cggagtatta aatgttgtgt ctcctgattt tttctatatc agaaaagatg gatcattact 1326961 tctccgttca gctaatcccg atgtgattaa agctcttcat agaagaaaat taaaagtagt 1327021 tccttttcta agcaatcatt gggatcagga tttgggacga tttgcattaa tgaaccgagt 1327081 tcttttagct aaacaaattt ctcatgcaat agaagaactg gatttggatg gagttaatat 1327141 cgatatagaa aaccttacag aaaaagatcg gaatctattt acagatttta ttagattagt 1327201 aaggaaaagt attcctagac ataaagaagt atcagttgca gtggcggcaa atccttttgg 1327261 ctggacgaag ggctggcacg gatcatatga ttacgagtat ttagctaaat atgcagatta 1327321 tcttatggtt atggcctatg atgaaagccg ccttgctggg cctactgcaa gtgtaggatg 1327381 ggtggaaaag tccattcaat atgttctgac ccaaaaaatc tctcctcaaa aactagtttt 1327441 aggattgcca ttctatggcc gctgctggat ggaaggccaa tctgcctctc aagccattcc 1327501 cctttacctt gttgttagta aaaaggcata gcgggacaat tatttttgac accaagagtc 1327561 aatctccaaa agctattttt actgtcaatc acgataaaaa ggggccgttg ccttcgggaa 1327621 catatacatt atggtttgaa aatgaacagt cactcagagc aaaaataaaa ctcgctcaaa 1327681 aatataatct gaaaggtctt ggcagctgga gtcttggaca agaagatgcg tcagtctgga 1327741 atacagtgtt taaaaatata taatgattta tagttcagaa caaaattcga agataattgc 1327801 aatgaatctc taaatggaca tactgaaagg agtttattac gagtgcgggt aaaacagtga 1327861 gggcattcca taggcccttc tcccaaaatg ttctacacga ggcattacat tgggcttgaa 1327921 atacacattc aaacttatgt tatagtacgc attttacgga tgtgttgaat ttattctgct 1327981 tccatgattt aatcatacac atgctacttg atagcagggt tatcgcattt cattcagaat 1328041 tgttcaggat cgatatggaa gcgcacgact aactagaact ttaaaagcat acactcatat 1328101 acttcctgaa tggatgctgg tttatctaaa aaacatgatg agaattgatt gtacgcatgg 1328161 tgaagcatga cttgttgata atcgaccata tggtttctcc ttagaaatga gggggttttt 1328221 acataaaaaa gacgagcgaa tccgggggga attccactcg ccgctttcta atgaaaagac 1328281 gggatgctgg atggcagctc gtctgtttta ttataattta acgaacgtat gtttgtaaag 1328341 gtgtcttttc gaatgaattg gttcatataa ccgttaagaa cagattcatt gtaaacattc 1328401 gctaaggtat gctaagatgc atggactata aaggagtgat atgaagtgaa gacattgcgg 1328461 ttaaacaatg taacgttaga aatggctgca tatcaagagg agagcgagcc gaagcgaaaa 1328521 attgcattta ccttaaacgt tacgagtgag acttaccatg atatcgctgt cctgttgtat 1328581 gaaaaaacgt ttaatgtcga ggttccggaa cgcgatcttg ccttccgggg ggaaatgaca 1328641 aattattcaa catcattgac caacctgtac gaaccagggg ccgtcagcga gttctatata 1328701 gaaataacgg aaatagacaa aaacgccgat tcatgatcgg tgttttttat gtaaaaaagc 1328761 tgccggccgg cagcttttga gaaagcgaat ttcatatgta aggtgttaaa ttgtccgtct 1328821 tgcagttttt tgaataaatg tggaaataag gaggttttaa taggagtctc tgatgatctt 1328881 ataattttta tgattaacaa ctgtcaatga atctaactca agatcccgat agttatccat 1328941 gatcgtcaca tcaacgataa cagaattctc atttactttt tcaacaacac cggttaatcc 1329001 gtttttaaat tcaatgacat tcccaacctt agcgattttc acaagcttcc tctcctttaa 1329061 acataataat gccttttgaa agtattttgc agtattttca ttgagaagta aagcgataag 1329121 gagttttatc tcccttatga attgttctgt cgctataaag atgatatatt gattttcgtc 1329181 aatagaaaga aaagggggga atttttgttg cgtcccgaag aaataacaga aatgattgaa 1329241 cagctgcgca ccggcgccat aaacgaactg agagtccaga aagagcattt tcttgatttc 1329301 agggccgtgt tatctaaaca agatgatttt aaacatttcc gaggaattgc ccagcaaggc 1329361 ggagatgtta tctttcaata cttagaacag ccaagaagct gaaggtttct catacgtgag 1329421 aagccttttt atcatatatg acagaacaca agccttttat tacagctgtc tgtaacaggt 1329481 gtaaataaaa tgtaaagtac caaagatgga taaacatgtt ttaatttaac aatatttata 1329541 gaatttcaga ctgttttttt gccattaagc agtgagtcat cctctttatt ccatcctgat 1329601 acctccttgg gagagttgga aaatcttttt ccgtgaaaat gaatggatct cttgttaagg 1329661 ttatgaagtg ttttttggag cactttaagg aggaaactgt atgacaacga aattcactgc 1329721 tctggctgtt tttcttcttt gtttcatgcc tgcagccaaa attgagcata cacaagcttc 1329781 actactgagc gcaaagaaga caaaacatga agaagcgaaa tggcttacac atatagatcg 1329841 aaatacgaat gaatctttcc cttcactgtc tgctgataaa gacaagaaaa taaaaccgat 1329901 taagctatca gcacacactg aaaagaaaga gaaagataaa ccggacaaaa caaatgatga 1329961 gaaagaaaca tatacacagt ctgaaaaaga gttgctgtcc cgtctcgttc acgcagaggc 1330021 caaaggagaa tcatataaag gcaaggtcgc tgtagcaagc gttgtactga acaggacgga 1330081 gaaaaaaggt tttcctgata cgataagagg agttatttat cagaaaaacg cctttgaacc 1330141 ggtcgcaaac gggagcatta accaaaagcc tgataaagaa tcgattgaag ctgccgaaga 1330201 agcgctgtcc tcaaaaaata gagaaacaga tgccatattc ttttataatc cgaaaacagc 1330261 gtcagataat tggattcgtt caagaaaaat cgtagaaaaa atcggcagac acgtttttgc 1330321 cgtctaagca tagaagagac aatttgtctc agctgtgctt tttttcatat aaagagtaaa 1330381 aataaaataa tttttgaact tgtctcatat gatgttggta gtacaagaga caaggagaga 1330441 catcatgaat cgatttgtga aagggatcat tcttttatcc attgccgcct ttttcgctga 1330501 atgccttgaa tttgtcgtca atatgatttt ggcgcgggag cttggcgagc atgggatggg 1330561 gctttacatg agtattttgc ccacgatctt tttaattatt gtcatcgcga gcctggaact 1330621 gccgatatcc atttctaaat tcattgccga gtcaaatcct aagcttcatg aaagcatgct 1330681 gaggcacgct ttcagaatga cagccatttt tactgctttt tctactgccg ccgctagtat 1330741 tgcgcttccg tttattccgg tatttgatac ataccacccg tttattaaag ggattgtcat 1330801 cggcttaatt cctgttgtcg cctttacttc aatcgccagg ggctacttta tgggtgtgca 1330861 gaaaatgggg aagatcgcaa ttgccaatgt gctgaaaaaa atcatccagc tcttgtgctt 1330921 attcctcttt tttcaatggt actcatttga attggacatg gctgtgctga tttccttgtt 1330981 tgttctagtc gtgagtgatg tggtcgtgct tgtttattta tattcacaat ttatcatggc 1331041 aaggcgggcg ttatccggcc agcagcacat tcatttgcgc ggaaaggatg taaggaaaag 1331101 actgcttgct gtttcaattc ctacaacagg actgcgtatt tttcatgcgg ttgtcaatgc 1331161 aattgaaccc tttttagtaa aaggagctct tttggctgcg ggcgttgccg ggacagcggc 1331221 gatcgatcaa tacggaatgc tggcaggagt ggctgtgacg atagggtcgt tccctgcttt 1331281 tattgcccat tcgttaatgg tcgtcatgat accgagtatt tcggaagctt atgcactttc 1331341 tcagtatgac atcgtgttaa aaaggctgaa gcagtcgatt ttcattacat taggttacgg 1331401 tatacctgcc gtctgggtca tgttccagtt tgcgggacct ctcacgcatt tgttttttca 1331461 ctctcctgaa gcgcagtatt acttgcagct gttgtggcct tactttctct ttcatctgtt 1331521 tgtcatgccg ctgcaggcgt gcttaatcgg gatgggtttt gtgaaagagg ctttttatca 1331581 caatgtatgg agccatatcg ttgcgctaag tatgatgtat gtactgggat caatggagaa 1331641 tctgcaaatg ctcgggatta tccttggaat gaacactggc atgattcttt tgacgagcct 1331701 gcactatgcc acgatctgca aagcattgaa ggtatctgta tttcttacgg gagggaccag 1331761 aacgccgcga attgaaggat gataaaggaa cagcaggggc aagctaattg aaaagcatga 1331821 aaggaagatt ccatgttgac gaagcgcttg cttactatat acattatgtt attagggttg 1331881 attgcatggt ttccaggtgc ggcacaagct gaggaaaaac agcctgctgt tcccgctgtt 1331941 tttcttatga aaacgataga aggggaggac atctcgattc cgaataaagg gcaaaaaaca 1332001 attctccatt tttggacgtc atggtgcccg ccctgcaaaa aggagcttcc acagtttcaa 1332061 tcgttttatg atgcccatcc atccgacagt gtaaagctgg taacggtgaa tttagtgaat 1332121 tcggaacaaa atcagcaagt cgttgaagac tttattaaag caaacaagct gacgtttccg 1332181 attgtccttg actcaaaagg ggaattgatg aaggagtatc atatcatcac gatcccaaca 1332241 tcatttttgc tgaatgaaaa gggagaaatt gaaaaaacaa aaattggccc gatgacagcg 1332301 gaacaactga aggaatggac ggaagaatag ctgagagcat agactctcag cttttttcat 1332361 atagagaaga agtgaataaa cattaatgat aattattatc aaaaagaaat taaaataatt 1332421 ataattgaaa ttctcttcgt gcgtgctata ataaaggaag acatcaagaa ataactgacg 1332481 ataaagctgc cttttgggca gcgattttgt ttttataaga gaaatgaaga tgatttacgt 1332541 tctcaattag agaggagaat tcgatatgaa tgaacaagtt atcgttcaac gcgacccgca 1332601 tgagccattg aaaacagaca agagggaaaa aaactgggca cagcacgcgg agcttattgc 1332661 agcacttgta tcaggcgctc ttattttggc aggctggctc ttatccggat atcaggtatt 1332721 atccataata cttttcttgc tggcttttgt gatcggcgga tttgctaaag cgaaggaagg 1332781 aatcgaagaa acactcgaat ccaaaacgct gaatgtagaa cttttaatga ttttcgctgc 1332841 cattggttcc gccttgatcg gatactgggc agagggtgct attttaatat ttattttttc 1332901 cttaagcgga gctttagaaa catacacgat gaataaaagc agcagagatt taacgtcttt 1332961 aatgcagctt gagcctgaag aagcgacatt gatggtcaat ggtgaaacca aaagagttcc 1333021 ggtttcagac ttgcaggccg gtgatatgat tgtgatcaaa cctggagaac gcgtagcggc 1333081 agacggtatc attgaatcgg gctcgacaag tcttgacgag tcggctttaa caggtgaatc 1333141 aatgcctgta gaaaaaaaca caggcgacac tgtattcaca ggaacggtga atcgcaatgg 1333201 ctccttgaca gtccgtgtca cgaaagcaaa tgaagattcg ttattcagaa aaattatcaa 1333261 actggttgaa tcagcgcaaa atagtgtttc acccgcgcag gctttcatcg aacgatttga 1333321 aaatgcttat gtgaaaggtg tgctaattgc ggtggcgctc cttttattcg tcccgcactt 1333381 tgcgctgggc tggagctgga gtgaaacctt ctaccgcgca atggtgttta tggttgtcgc 1333441 gtcaccttgt gcgcttgtcg cctctattat gccggcggcg ctgtccctga tttcaaatgg 1333501 cgcccgcaac ggtatgcttg tgaaaggaag cgtctttctt gaacagctgg gctcagtgca 1333561 aatgatcgcc tttgataaaa ccggaactgt aacaaaaggc cagcctgccg tagagacgat 1333621 cagaatagca gaaggattca gtgaagcgga agttcttgag gctgtctatg ccatcgaaac 1333681 gcaatcaagc catccgctcg cccaagccat aacggcgtac gctgaaagcc gcggcgtgaa 1333741 tcagtccggc tacatatcta tagaagaaac ctcagggttt ggcgttatgg cagaagtgtc 1333801 gggtgcgaaa tggaaggtcg gtaaagcagg ttttatcggc gaggaaatgg cagcacaatt 1333861 tatgaaacaa acagcatcag atgtcattca aagcggtcat acaattgtat ttgtgaaaaa 1333921 ggatgatcaa atagcaggct gtatcgcact gaaggaccaa atcaggcctg aagcaaaaga 1333981 ggtcatggaa gaactgaacc gacttgggat taaaacggcc atgctgacag gagatcacga 1334041 agacacggct caagcgattg ccaaggaagc cggcatgaca actgtcgtgg cagaatgcct 1334101 gcctgaccaa aaagtgaatg aaatcaaacg gttaaaagaa gaattcggaa cgattgcaat 1334161 ggtgggtgac ggaatcaatg atgcgccggc actcaaagca gcggatgtcg gcattgcgat 1334221 gggcggcgga acagatgtag cacttgagac cgctgatatg gtcctcatga aaaacgattt 1334281 gaaaaagctc gtaaacatgt gccgcttgtc tcggaaaatg aacaggatca tcaaacaaaa 1334341 tatcgtgttt tctctagctg taatctgcct gctgatttgt gcaaactttt tgcaggcgat 1334401 ggaattgcca tttggcgtga ttggtcatga gggcagcacg attttagtca tactaaacgg 1334461 tttaagactc ctaaaataaa accagcagcc taatcaggct gctggctttt tatgtatcaa 1334521 gctttccctt catttttgtc tttatcagat cttttcataa ctaggatgag agcgagggtg 1334581 cagcaaagga aacccgctgc acagcctatg atagagctgt aataataaaa gcccaccatc 1334641 ttcatcccga taaaaggagc ggaaattccc aaaaccgtta agagcataac tgcttttcgt 1334701 ctgaaaaaat tcatcagcaa acggaacaac ccccctgcga ttgaacgtta ctgtcagtat 1334761 acaggaagag gagcaggaaa taaaatgcat tagaaaatga aggcgtcgtg aaaggcaaac 1334821 accggtaaaa cctgttacaa tggaagacag aacaatgcat tgcaaatggc agggaggaac 1334881 aagaagtgaa tagaatacaa cgcgtctctt catggctgaa ggaagcgggg catactgccg 1334941 catttattca tacgaaagaa aatgtttttt acttaaccgg tttttacaca gagccgcatg 1335001 aaagattaat ggggttattt atttttcaag aagaggagcc tttctttgtt tgtccaggaa 1335061 tggaagcagg acaggcccgc aacgcaggct ggaatcatga aatcattggc tatgcggatc 1335121 acgaaaatcc gtgggagctg atagagaagg ctttgaaaaa gcgaaatatc agcatacata 1335181 tgcttgcggt agaaaaggat tcaatctcgc tgtcacgtgc agaacagctg aagcatgcga 1335241 cgggcggggc tcaatttgtt tcagcagaag aaacactcaa tcaatttcgc ctgattaaag 1335301 atgacaatga gattcgtttg ctgaaagagg cggcaaagct tgcagattac ggtgttgaag 1335361 tcggcacagc cgctttgcgt gaaggcatca gtgaagtgga agtgctcgct caaattgagt 1335421 atgagctgaa gaaaaaagga attcagggca tgtctttctc tacaatggtt ttattcggag 1335481 aaaaatctgg ccagcctcat ggaaatcctg gtacagccac gttgaagaaa ggtgattttg 1335541 ttttatttga tctcggtgtt attcttgatg gctattgctc tgatattaca agaacgtttg 1335601 catacaaaac catcaatccg aagcaggagg ccatttacga gactgtgctt caagcggaaa 1335661 aagccgcgat tgaggcaagc aaacccggtg tgagaatcgg agatctggat ttaactgccc 1335721 gcggaatcat tgaaaaagcg ggatatggtg attattttcc tcaccggctt gggcatggac 1335781 tcggaatttc agtccatgag tatccatcaa tgagccaggc caacgataca ctgctgcagg 1335841 aaggcatggt ctacacgatc gaaccgggga tttatgtgcc agagatcggc ggcgtacgca 1335901 ttgaggatga cgttcacgta acaaaggacg gagcagttgc tctgacccaa tatccaaagg 1335961 atttgatcat actgtaatag aaataaaaaa ggactttgtt ctcgacatcg tcctttttta 1336021 tctgcattaa ataaaaaaat catcaaatgt tcgaaagggt ttaatttcat gtttttggtt 1336081 gagaggtttt acagcaagac agctgccacc gagaacagtg agacataacc caattaaaat 1336141 gaagaaaccc atgtgatctt ctcctttcag ctaaaaacac aaaaagatat ctggtacgtc 1336201 catatcatat tgtatgaaac gcattccaga tcaaggggat ttagaaagaa gggaatctat 1336261 ggctaatatt aaagacattg cagagaaagc cggtgtctct gttacaacgg tttcccgagt 1336321 cataaacaat catccatacg tcagtgaaga caaacgaaaa agagtgtttg aggcaatgga 1336381 atcattggag tacacgagaa atattcacgc tgtacatttg tcgaaaggat tttcaaacat 1336441 gattggtgtt gtcttgccga cggttaatct gccatatttt gcagagctga ttgcaggaat 1336501 agccgacgca gccgcggaat ccggggttca cctctcttta ttccaaacaa actatgaagt 1336561 acaaaaagaa atctttgcgc tgtcccaatt aaagcagcgc caggttgacg gcctgatttt 1336621 ttgctcaaag gcgcttgctg atgagaaact catggaatgg gagggcccga ttttgctttg 1336681 ccagaattca gataatgccc gcttcccaac catcagcatt cctcaccaag aagcatttcg 1336741 gaacggcttg gactatttaa ttgccaaagg gcacaaaaaa atagccatct gtttggcaag 1336801 aaaaaaaggc atgaacagcc attttcgaat caaagcctac aaagaggcat tggaagagat 1336861 cggcgaggca tttcgtgaag actgggtaat tgagaaagcg attacaatca atgatgggaa 1336921 ggcgcttttt cataaatgga atacgtggaa ggaaaagccg acggctattt ttgttgccaa 1336981 tgaccaagtc tcagcagggc tttttcttga agcaaagaac cagcgggtgt cagtaccgga 1337041 tgagcttgca atcttaagcg ttgataacca cgaaatcagc caagcgcttg gaatcacaac 1337101 gatcgatatt cagacaaggg aaatgggaaa gcaggcattt gccatattgg aaaaaagaat 1337161 tcaaggacag ccgattgaaa ggaaagttct ggattaccgt ctcatcgaaa gatcgactgt 1337221 ttagtgaatg cattgaaaaa aggtttgacg tgcattctgt tcgttatgta cgatatgagg 1337281 tattgaatga caaaggagct gaggatcgtg aatgggtcct tcacagtgaa aaaggtactg 1337341 aataataacg tattaattgc ttctcatcat aaatacagcg aagtcgtttt aatcggaaaa 1337401 ggtattggtt tcggaaaaaa acaagatgat gtcattgaag ataaaggcta cgataaaatg 1337461 ttcattttaa aagacgagaa ggaacaaaag cagtttaaaa agctccttga ctatgttgat 1337521 gaaaagctcg ttgatatttc aaacgatgtc atctatcaca taagcaatag gacgaatcac 1337581 tcattaaatg aacatattca cattgcgttg acagaccata tcgcatttgc gatcaaaagg 1337641 cagcagcagg gatttgatat gaaaaatcca tttctaatgg agactcagtc actatatcct 1337701 gaggagtacc aaattgccaa agaagtcata gatatgatca atgaaaaagc gggactctgc 1337761 cttccggaag gggagattgg ttttatcgct ctgcatatcc attcagcgtt gacaaaccgt 1337821 ccgctgtccg aggtcaatca gcactctcag ctcatggcgc agcttgtcga ggtgattgaa 1337881 gactcatttc aaatgaaagt aaataaggaa agtgtcaact atttgcggct gatcaggcat 1337941 atcagattta caatagaaag aattaaaaaa gaagaaccga ctaaagaacc agaaaaatta 1338001 atgttgttat tgaaaaatga atatccgcta tgctacaata cagcttggaa attgattaaa 1338061 atcttgcagc aaacattgaa gaaaccagtt catgaggcgg aagcggttta tctgacgctt 1338121 catctgtacc gattaaccaa taaaatttca taaattcagt ttatccttat aacgtgttac 1338181 tgattcgatc aggcatgagt gattgaggga aaaaaacggg aagttcattc tcgttctttt 1338241 gcgcacccaa ttttgctcat gcctttttgt tgtgtaaaag ggcaaatgta aacggttaaa 1338301 ctggaagact tacgcctgtg aattcgttgt catgattttt agctgtaagg tcagactagt 1338361 aaaaagagga ggtcaattct tatgtttaaa gcattattcg gcgttcttca aaaaattggg 1338421 cgtgcgctta tgcttccagt tgcgatcctt ccggctgcgg gtattttgct tgcgatcggg 1338481 aatgcgatgc aaaataagga catgattcag gtcctgcatt tcttgagcaa tgacaatgtt 1338541 cagcttgtag caggtgtgat ggaaagtgct gggcagattg ttttcgataa ccttccgctt 1338601 cttttcgcag taggtgtagc catcgggctt gccaatggtg atggagttgc agggattgca 1338661 gcaattatcg gttatcttgt aatgaatgta tccatgagtg cggttcttct tgcaaacgga 1338721 accattcctt cggattcagt tgaaagagcc aagttcttta cggaaaacca tcctgcatat 1338781 gtaaacatgc ttggtatacc taccttggcg acaggggtgt tcggcggtat tatcgtcggt 1338841 gtgttagctg cattattgtt taacagattt tacacaattg aactgccgca ataccttggt 1338901 ttctttgcgg gtaaacgttt cgttccaatt gttacgtcaa tttctgcact gattctgggt 1338961 cttattatgt tagtgatctg gcctccaatc cagcatggat tgaatgcctt ttcaacagga 1339021 ttagtggaag cgaatccaac ccttgctgca tttatcttcg gggtgattga acgttcgctt 1339081 atcccattcg gattgcacca tattttctat tcaccgttct ggtatgaatt cttcagctat 1339141 aagagtgcag caggagaaat catccgcggg gatcagcgta tctttatggc gcagattaaa 1339201 gacggcgtac agttaacggc aggtacgttc atgacaggta aatatccatt tatgatgttc 1339261 ggtctgcctg ctgcggcgct tgccatttat catgaagcaa aaccgcaaaa caaaaaactc 1339321 gttgcaggta ttatgggttc agcggccttg acatctttct taacggggat cacagagcca 1339381 ttggaatttt ctttcttatt cgttgctcca gtcctgtttg cgattcactg tttgtttgcg 1339441 ggactttcat tcatggtcat gcagctgttg aatgttaaga ttggtatgac attctccggc 1339501 ggtttaattg actacttcct attcggtatt ttaccaaacc ggacggcatg gtggcttgtc 1339561 atccctgtcg gcttagggtt agcggtcatt tactactttg gattccgatt tgccatccgc 1339621 aaatttaatc tgaaaacacc tggacgcgag gatgctgcgg aagaaacagc agcacctggg 1339681 aaaacaggtg aagcaggaga tcttccttat gagattctgc aggcaatggg tgaccaggaa 1339741 aacatcaaac accttgatgc ttgtatcact cgtctgcgtg tgactgtaaa cgatcagaaa 1339801 aaggttgata aagaccgtct gaaacagctt ggcgcttccg gagtgctgga agtcggcaac 1339861 aacattcagg ctattttcgg accgcgttct gacgggttaa aaacacaaat gcaagacatt 1339921 attgcgggac gcaagcctag acctgagccg aaaacatctg ctcaagagga agtaggccag 1339981 caggttgagg aagtgattgc agaaccgctg caaaatgaaa tcggcgagga agttttcgtt 1340041 tctccgatta ccggggaaat tcacccaatt acggatgttc ctgaccaagt cttctcaggg 1340101 aaaatgatgg gtgacggttt tgcgattctc ccttctgaag gaattgtcgt atcaccggtt 1340161 cgcggaaaaa ttctcaatgt gttcccgaca aaacatgcga tcggcctgca atccgacggc 1340221 ggaagagaaa ttttaatcca ctttggtatt gataccgtca gcctgaaggg cgaaggattt 1340281 acgtctttcg tatcagaagg agaccgcgtt gagcctggac aaaaacttct tgaagttgat 1340341 ctggatgcag tcaaaccgaa tgtaccatct ctcatgacac cgattgtatt tacaaacctt 1340401 gctgaaggag aaacagtcag cattaaagca agcggttcag tcaacagaga acaagaagat 1340461 attgtgaaga ttgaaaaata agggtgttag tacgccgtgc ttgtcagatg acaagtacgg 1340521 ttgtatgata taatattgtg aagtaataaa gctttaagtt aaaaggagaa tgataaaaat 1340581 ggcacaaaaa acatttaaag taactgcaga ttctggaatc catgctcgtc ctgcgacagt 1340641 tcttgtacaa actgctagca aatacgacgc tgacgttaat ttagaatata acggcaaaac 1340701 agttaacctt aaatctatta tgggtgttat gtctttaggt atcgctaaag gcgctgagat 1340761 cacaatctct gcttccggag ctgacgaaaa cgatgctctt aacgctttag aagaaacaat 1340821 gaaaagcgaa ggactcggcg agtaatgcaa gaattaaaag ggattggtgc ttcagccggc 1340881 atcgcgattg caaaagcgta ccggcttgaa gagccagatt taacggttga aaagaaaaac 1340941 atctctgatt ctgaagcgga agtaagccgt tttgatgaag cgattgcacg ttcaaaagaa 1341001 gagctcgaaa aaatcaaaga gcacgctttg aaagaactgg gtcaggataa agctgatatt 1341061 ttttctgctc accttttagt tctcagtgac cctgagcttc tgaaccctgt gaaagaaaaa 1341121 atcagcactg attcagtgaa cgctgaattc gctttaaaag aaacgtcttc tatgttcgtt 1341181 actatgtttg aatctatgga caacgaatat atgaaagagc gtgcggcaga tatccgcgat 1341241 gtaacaaaac gcgtaaccgg ccacctgctt ggcgtcgaaa ttccaaaccc aagcatgatc 1341301 tcagaagagg ttattattgt agctgaagac ttaacaccgt ctgacacagc tcaattaaac 1341361 cgtgagttcg taaaaggatt cactactgat atcggcggac gcacatctca ctctgccatc 1341421 atggcacgtt ctcttgagat tccagcagtt gttggaacga aagctgctac aggcacgatc 1341481 caaaacggcg tgactgttat cgttgacggt atcaatggcg atgtcattat tgacccatct 1341541 gcggaaactg taaaagagta tgaagaaaaa cataatgctt atttggctca aaaagctgag 1341601 tgggcgaagc ttgtcaatga accgactgtc tcaaaagacg gacatcatgt agagcttgca 1341661 gcgaacatcg gtactcctga tgatgtaaaa ggtgttcttg aaaacggcgg agaagcagtt 1341721 ggcctttacc gtacagaatt cctttacatg ggaagagatc agctgcctac agaagatgag 1341781 cagtttgatg cttacaaaac ggttcttgag cgtatggaag gaaaatcagt cgtcgtgcgg 1341841 acacttgata tcggcggaga caaagagctt ccttacctgc agcttcctaa agaaatgaac 1341901 ccgttcctgg gatatagagc gattcgtctt tgccttgaag agcaagaaat cttcagaaca 1341961 cagcttcgcg cgctgcttcg tgcaagtaca tacggaaact tgaaaatcat gttccctatg 1342021 attgcgacag ttaacgaatt caaagaagca aaagcgatcc ttcttgaaga gaaagaaaag 1342081 ctcgtaaaag cgggacaggc tgtatctgac gatattgaag tcggaatgat ggttgagatt 1342141 ccgtcaactg cagtcatcgc tgatcagttt gctaaagagg ttgatttctt cagtatcgga 1342201 acaaacgatt tgattcaata cacaatggca gctgaccgta tgaatgaacg tgtatcttac 1342261 ctgtatcagc catacaaccc ggcaatcctt cgcttaatta cactggtaat tgaagcagca 1342321 cacaaagaag gaaaatgggt tggcatgtgc ggagaaatgg caggagacga gattgcgatt 1342381 ccgatccttc tcggcttagg cttagatgag ttctcaatga gcgcaacgtc tatccttccg 1342441 gcaagaacac aaatcagcaa attgtctaaa caagaagctg agtcattcaa agagaaaatc 1342501 ttatctatga gcacgacaga agaagttgtc gcgttcgtaa aagaaacatt caagtaatgt 1342561 acaaaaacca gacggcctcc ggcctgtctg gtttttttca taagtaaggg tatagaagga 1342621 cacaataaca tggctaggag ggatagtatg tcaaaccaat ttaacgcagg agatactgtt 1342681 tatgtgatct acagaaatcc gcacgccgcc aatgtagccc acataaagga agccgaaatt 1342741 gtgcaccatc cataccatga aggcgagctt tccctgttta tttatgaaac ctatcatcca 1342801 ttcgcagagg acgatgctgt gtttgcaagc tatgaagaag ctaaatcgct ttacaaagaa 1342861 ctgtttgata ttgatccgta tgagtaacaa ggaaatcatt acaactcata tcctttccgc 1342921 ctagtgagaa aagtaacgtt agtaaaggaa aaggatgtgg catcatgcag aacccatttg 1342981 ttccgcagct tgtgtatata gaaccgaggg cgctggaata tccgctgggc caagaattac 1343041 aagataaatt tgagaatatg ggtattgaaa tcagagaaac gacatcccac aatcaggtgc 1343101 gtaatatccc tgggaaaaat catcttcagc aatatcgcaa tgcgaaatca actttagtta 1343161 tcggtgtccg gaaaacatta aagtttgatt catccaaacc ctcggccgaa tatgccattc 1343221 cgtttgcaac aggctgcatg gggcattgtc attactgcta cctgcaaaca accatgggat 1343281 caaagccgta tatcagaact tatgtaaacg tcgaagagat tttagatcag gcagataagt 1343341 atatgaagga gcgcgcacca gagttcacaa ggttcgaagc atcatgtacg tcagacattg 1343401 taggaattga tcatctgaca cacacgctga agcgcgccat tgaacatttt ggccaaagtg 1343461 atctcggaaa gctccgattt gtaacgaaat ttcatcatgt cgatcaccta ttagacgcaa 1343521 agcataacgg gaaaacgaga ttcagattca gtattaatgc cgactatgtg attaaaaact 1343581 ttgagccggg aacttcacct cttgataagc ggatagaagc ggcagtaaaa gttgcaaaag 1343641 caggctaccc gctaggcttt attgttgctc cgatttatat tcatgaaggc tgggaagaag 1343701 gatacagaca tctgtttgaa aagctagatg ctgctttgcc gcaggacgtt agacatgaca 1343761 ttacgtttga attaattcaa caccgtttta caaaaccggc caaacgagtg atagagaaaa 1343821 attatccgaa gacgaagctc gaattagatg aagaaaagcg ccgttataaa tggggccgtt 1343881 acgggatcgg aaaatatatt tatcagaaag atgaagagca tgcacttcga gaggcacttg 1343941 aatcctatat tgataccttt ttccctaacg caaaaattga atatttcact taaacgggct 1344001 gttgtgatca acagctcgct tttttataaa aaacattttt ccattccatc aaaacgccgt 1344061 aattcaatga ttctttatcc tccaaataat tgctgactac acgaataggt gaacgcccgc 1344121 aacggaggag aaaggacagc acagggtcgt ttttcctgcc ttccatcaca tcttcaacgt 1344181 actgaacagc gctgatctcg tgtgcgtatt tataatacaa aggaatgcgg ccgccgccga 1344241 gaaggcgttc cagtctttta tcaacagtca gctcatacat cgtattcatc agccattttc 1344301 cgattccaag ctttcgataa tgaggagaaa cagaaatatc cactacatat aaagtatttc 1344361 catgaggttc atgattttta atcgatccgt tgtcagttgc ttgtgcccat gtatgatcag 1344421 gagaatcagg ctcaaattgt acaataagag cagtcatgga accgataatt ctgccattga 1344481 tgagcgcgca taaagcgcct tccggaaagg ttttgatatg gctggcaagc tggtcctctg 1344541 accacagcaa ttcctgggga aacggaggag ggaaacattc ttcttgaaga gaaatcagcc 1344601 tctcgatgtc agtctcagtg tagtttctaa tggtcagagc ctcaaatttt ctgccgtcat 1344661 gcacatacat ttgttttagt atgatcatca ctctccttat gttgtttcat tataacgaag 1344721 attgaatttt cagtaaatat attccgattt tcttataatt tattttttga ttattcattt 1344781 ttcaaacgaa agggccgata tagaaattag gaggggattg gtttgtttaa aaaacttcac 1344841 atgaagattg ctgtttttgt ttcgattatg ttaatcatca cagttgttct cttaatgctg 1344901 tcttcttatt tgacgctaaa accgatgatt acagaggatg ggaaaaatac aactcaaaac 1344961 gtgacgcagt cacttgaaca aaatattgaa ttgcaattaa agagttatgc catttcgtta 1345021 tcaagattgg ctaatgggga attaacgcat acatttgtaa cgaaaccaag taaagaagct 1345081 tctcggctgt ttcacgatga cattaagcaa atcaaagaca acgatgatta tgttgcgatg 1345141 gcttacatag gcaccgcaaa aaaagaaatg tttacatatc caaaagcgga tttcgctgag 1345201 gattacgatc caacatcaag accatggtat aagcttgcag ctgaaacccc ggatcaagtt 1345261 gtttggacgg aaccttataa agatgtcgtg acaggagaca tgattgttac tgcatcgaaa 1345321 gcgatcttag acaggcaaaa agtgataggg gttgccagct atgacttgaa actctctgct 1345381 atccagagta tggtcaataa acaaaaggtg ccttacaaag gatttgcctt tttagctgat 1345441 gcgagcggca atcttttagc ccatccgtca aatcaaggaa aaaatatatc aaaggatcaa 1345501 acactgcaaa ccatcgcatc cgagaaaaaa gggatacaag atgtgaatgg gaaaatggtt 1345561 gtgtaccaaa cgattggcga gacaggctgg aaggtcggaa cgcaatttga taccgatcaa 1345621 ttaatgtgga tttcagataa aatgaatcgg gccaatcttt ggatatcatt gattgcgctt 1345681 atcataacaa ttattctcag ctacttcctg gccaaaacga taaccggtcc gatacagcag 1345741 ctgatcgtaa aaacgaaagc tgtttccgca ggcgatttaa cagtgcgcgc ggaatcaaaa 1345801 tctaaggatg aagtcggtat tttaacaaga gatttcaatc tgatggttga aaatatgaag 1345861 gaaatggttg agcaagtgag actctcttca gggaaagtat ctgacacctc tgaacaacta 1345921 acggctgtgg ctgccgaaac taatgaaaca agcggacaaa ttgcaaaagc gattgaagaa 1345981 gtagccgcag gggcatcgga acaggcttct gaagttgaaa ccattaatga aaaatcggaa 1346041 agcctgtcaa cgaaaatcag gcaaatcgct gaggaggcag gcggaattaa agaacgctca 1346101 aaatcgtccg aggatgcaag ctataaagga cttgacgcgc tcggccagct gctgatgaaa 1346161 tcaaacgaag ccaatatgga aacgaaaaag gttgaaacga tgctgctgga tttggaaaat 1346221 caaactaaga atattgaaga agtcgttaca gcgatttcaa acatatctga tcaaaccaac 1346281 ttgcttgcct taaatgccag tattgaggca gccagagccg gagaaagcgg gcgcggtttt 1346341 gccgtcgtag ccgatgaagt gcggaagtta gctgagcaat cagccctttc tacaaagcat 1346401 atcagcgaga ctgtgaagct tatccagctt gagacaaaag aggcctctca cgcgatggtt 1346461 gaggcaagca gaatgaatga tgaacaaaac agtgcaattc acgaaactgg agaggtatta 1346521 aatacgataa ctgcagaaat gcagtcactg gtacaaggta ttgatcacat ttacgcggaa 1346581 attcaaagaa tgagtgaaga acagcttgcg atttctgaag ccattcaaag catttcagcc 1346641 atatcacagg aatcagctgc cgcagcagag gaagtgaacg catcaaccga tgaacagctt 1346701 gtcacccttg ataaagtcaa acactcaacg gaaacactaa aacatgcaag ccaagagctt 1346761 atgaacacaa ttgcaaaatt cacattgtaa tccaattaca tccccaaaca tcatttgttt 1346821 tggggatttt ttattttata agatgaatag atatggtagt ctagaaaatg aaggaaaaat 1346881 gataaatttt aactaaaatc taaacgaaac atctgggagg aatgaccttg aaaaaaacaa 1346941 ttggttttat cggtcttgga gtaatgggaa aaagcatggc atcacatatt ctcaatgacg 1347001 gccatcctgt attggtgtac acccggacaa aagaaaaagc agaaagcata cttcaaaaag 1347061 gcgcgatctg gaaagatacg gtcaaagatc tttcgaaaga agcggatgtt atcatcacaa 1347121 tggtcggcta tcccagtgat gttgaagaag tgtatttcgg aagcaatgga attattgaaa 1347181 acgcaaaaga aggtgcatat cttattgata tgacgacatc taagccttcg cttgcgaaga 1347241 agattgctga agcggccaaa gaaaaagcat tgttcgcttt agacgctcct gtttccggtg 1347301 gagacatcgg tgcacaaaac ggaacactcg cgattatggt cggtggagaa aaagaagctt 1347361 ttgaagcctg catgccgatt ttctctttaa tgggagagaa tattcagtat caaggaccgg 1347421 ctggaagcgg acagcatacc aagatgtgca atcagattgc aattgcagcc ggtatgatcg 1347481 gtgttgctga agcgatggct tatgcccaaa aatcaggcct agagccggaa aatgttctga 1347541 aaagcatcac aacgggcgca gccggaagct ggtcattgtc aaatcttgct ccccgtatgc 1347601 tgcaaggcaa ctttgaaccg ggattttatg tgaagcattt tattaaggat atgggaattg 1347661 cactagagga agcagaatta atgggggaag aaatgccagg cttgtcgctc gcaaaatctt 1347721 tatatgacaa gctagctgct caaggtgaag aaaacagcgg aacacagagt atatataagc 1347781 tttgggtgaa ataaaaaaag attgcctgta cgaaacaggc aatctttttt tattattttc 1347841 cgatgaattg ttgtgtccag atgcttccag actcaacgta accaacaccg atgtgagtaa 1347901 agttagggtt tagaatgttt tttctgtgtc cttcactgtt catccaagct tttactactt 1347961 cttctggtgt cttttggccc ttcgcaatgt tttcacctgc tgttttgtag ctgattccga 1348021 aagatttcat catatcaaac ggtgagccgt atgttgggct ttggtgatca aagtagtttt 1348081 tgtctttcat atcctgagat tttgcgcgtg cagatttgct taacgtttca tcaatttgaa 1348141 gcggttttaa gccttgtttt tgtctttctg catttgtaag ttcaacaact tttttctcat 1348201 atgcacttac agatgaaggt gcagacgttg ttgtgtttgt tttttcagca gttgcgggtg 1348261 ctttagaagc agtgttttga tcagcagctg ctttttcagt agtcttttgt gcaggttttg 1348321 ccgtttctgt cttttgaaca tcctgaactt tcacgttaga ttgcttcgca tgtttttgaa 1348381 gaagctgctt catctctttt tcgtttgcag cgtttaacgt tttgatattt gtgttaatat 1348441 gcagtttttt cactgcatcg ttaagtgaca tgttttgtac tgtgttcccc gtttttactg 1348501 taaccacagg ctggcaggag agttctttcg ctgatgcttg ctgtacgccc ccgaatgtga 1348561 ataatccaac cgcagcggca gcagataaaa taaatgcttt cttcattagt tcgtaacctc 1348621 ctagagttgt ttgtttctac agaaaaatca taacatagct tttttgtcat aaagattcca 1348681 gcactttcct ttgacaaata gagattgtca ttttcgtaaa gtaaatccgt tgaatcacta 1348741 agaataaggg aatcagcggt atatatgatt ttatcgtacc gttacatagc ttcctttttt 1348801 ttgaaccgtt agttatattt taatgtgttt ttatattgac agcttttttt actccttttc 1348861 gctgtaacaa ctattacaaa ggtgttacaa ttaatctcag tatatgtaaa tatattgaat 1348921 gatttgagag gggtaaccag aagtgactga aataggacgt gaaccaaaga aaaagagcaa 1348981 aggaaacaga gcaatcagaa tgaacctttt tttcctagct gtctttgttc tattcactgc 1349041 attaattttt aagctcgggg ttgttcaaat tgttgaaggc gaacagcatg aagaagacgc 1349101 tgagaaatca aatgcaaaaa cagcttacta tcctgcgcct cgcgggaaga tgtacgacag 1349161 aaaccagaaa gttgctgtcg acaaccagag cgttccagaa attgtgtatg tatcaacatc 1349221 tagcacaaaa acagaagata aaatcaaaac agcgaagcgg cttgcttctt tcattcatat 1349281 tgataccgaa tttttgaagg aaagggatct tcgtgattac tggatcgcag ctcatccgaa 1349341 aaaagccgcc gctctgctta aggaatcaga aagcaatctg aaaggagacc aggcttacaa 1349401 gcttcaaata gagcgtgttc cggatcaaga attaaaggct attcagcaag atgacgaaga 1349461 aatggaaact gctgcgatat atacaaggtt ttcaagcgga aatgcttacg aacctcaaat 1349521 cgtaaaggca atgaatccaa ataagagcaa tagcaatgga aaaaacggag cgctgcttga 1349581 tgagaagaaa aactcctcgc aaagaccaaa aaatgactta acatatgatg aaatttccat 1349641 tgtttctgag catttagaag aacttccggg aatcgatatc gtaaacgatt ggacacgaaa 1349701 atatccttat gacaaaaccc tttattctgt tttcgggggc gtcacgacac ctgatcaggg 1349761 cctgctgagc gaccggaaag atttctactt aacaagaggc tatgcgaata atgacagggt 1349821 gggaaaaagt tatttagagt atcaatatga agaatattta aattcgcata aagaaaaagt 1349881 ggaatacgta gaagataata aaggaaatgt cgtcagccaa aaaaccattg ataagggcag 1349941 caggggatac gatcttcagc tttcttttga catggagctt caggcaaagg tagaaaagat 1350001 cattgaagaa gaagtaagaa acagccgtgc acgcggaaat tacatgcttg acagagcctt 1350061 tgccgtaatg atggacccga ataacggcga tattttatca atggcaggga aaaagataga 1350121 tttaaaaacc aacaaaattg aagattatgc gataggggca tttaccaccc aatatgaaat 1350181 gggatcagca gtaaaggggg ccaccgtgct agccggctat caggacggga tcccgcatta 1350241 taaatattat atcgatgctc caatgctttt aggaacgaat cttataaaaa aatcttatac 1350301 taatatggga accatcaatg aattaaccgc attgcaaaaa agttcaaacg tatatatgtt 1350361 caatgttgcc atgcatattg caggcgtaac atacaagccg catggatctc tcccggctga 1350421 tcagaacgat ctactgaaaa tgagaaacta ttacagccag tttggtctgg gagtaaagac 1350481 aggtattgat ctcccgcagg aatcagccgg aatgcaaacc acacctaaaa ctgtaggagg 1350541 attaatttta gacttagcaa ttggccaata cgatacatac acaccgcttc aaatggctca 1350601 atacatctca gtaatcgcca atggtggcta tcgtgttcag cctagaatcg tcacaagtat 1350661 tcataagcca ggaaaaaaag accagctggg taaggcgatt gaacatagga aacctaaagt 1350721 actcaataag attaataatt cagagagcga tttgaaacaa gtacaaacag gcatgaaatt 1350781 agtcacttct tcagggacag caaaaaatac gtttacagaa gatgtatcag ggaaaacggg 1350841 aacagcggaa acattttact acggcacgaa tcgcaactgg tgggggaaaa aaacatacaa 1350901 tctgactttt gtcggctatt acccgtcgaa aaaaccaaaa gtggccttta gtgttgttgt 1350961 tccatcagta gatgatgatg ataagatcaa taaaattatt gccaaaagag ctatccacgc 1351021 ctacgcagag ctcgaaaaaa aacacagtaa aaaataaaaa acagggtgca caactaaaag 1351081 attgtgtgcc ctttctttta ttcaaaaatt gacgttcacc ataagaatag aaggagaata 1351141 ctcattttct agcgaatcat actaggtaaa agtcaatctg tatatgtcga aacacgatga 1351201 tcatgcaaag gagggattct gtggaacagg atacgcagca tgttaaacca cttcaaacaa 1351261 aaaccgatat tcatgcagtc ttggcctcta atggacgcat catttatata tctgccaact 1351321 ccaaactgca tttgggctat ctccaaggag agatgatcgg atcattcctc aaaacgtttc 1351381 tgcatgagga agaccaattt ttggttgaaa gctattttta taatgaacat catctgatgc 1351441 cgtgcacctt tcgttttatt aaaaaagatc atacgattgt gtgggtggag gctgcggtag 1351501 aaattgttac gacaagagct gagcggacag aacgggaaat cattttgaaa atgaaggttc 1351561 ttgaagaaga aacaggccat caatccctaa actgcgaaaa acatgaaatc gaacctgcaa 1351621 gcccggaatc gactacatat ataacggatg attatgaacg gttggttgaa aatctcccga 1351681 gtccgctatg catcagtgtc aaaggcaaga tcgtctatgt aaacagcgcg atgctttcaa 1351741 tgctgggagc caaaagcaag gatgctatta ttggtaaatc gtcctatgaa tttattgaag 1351801 aagaatatca tgatatcgtg aaaaacagga ttatacgaat gcaaaaagga atggaagtcg 1351861 gaatgattga acagacgtgg aaaaggcttg atggcacacc tgttcattta gaagtgaaag 1351921 catccccgac cgtctacaaa aaccagcagg ctgagctgct gctgctgatc gatatctctt 1351981 caaggaaaaa attccaaacc atcctgcaaa aaagccgtga acgatatcag ctgctgattc 1352041 aaaattccat tgataccatt gcggtgattc acaatggaaa atgggtattt atgaatgaat 1352101 cgggaatttc cctgtttgaa gcggctacat atgaggattt aattggcaaa aacatatacg 1352161 atcagctgca tccttgcgat cacgaggatg taaaagagag aatccaaaac attgccgagc 1352221 aaaaaacaga atctgaaatt gtcaagcaat cctggttcac ctttcagaac agggtcatct 1352281 atacggagat ggtctgcatt ccgacgacct tttttggtga agcggccgtc caggtcattc 1352341 ttcgggacat ctcagagaga aaacaaacag aagaattgat gctgaaatcg gaaaaattat 1352401 caatcgcagg gcagctcgcg gcgggaatcg cccatgagat ccgcaaccct cttacagcga 1352461 tcaaaggatt tttacagctg atgaaaccga caatggaagg caacgaacat tactttgata 1352521 ttgtgttttc tgaactcagc cgtatcgaat taatactcag tgaactgctc atgctggcga 1352581 aacctcagca aaatgctgtc aaagaatatt tgaacttgaa aaaattaatt ggtgaggttt 1352641 cagccctgtt agaaacgcag gcgaatttaa atggcatttt tatcagaaca agttatgaaa 1352701 aagacagcat ttatataaac ggggatcaaa accaattaaa gcaggtattc attaatttaa 1352761 tcaaaaatgc agttgaatca atgcctgatg ggggaacagt agacattatc ataaccgaag 1352821 atgagcattc tgttcatgtt actgtcaaag acgaagggga aggtatacct gaaaaggtac 1352881 taaaccggat tggagagcca tttttaacaa caaaagaaaa aggtacgggg cttggattaa 1352941 tggtgacatt taatatcatt gaaaaccatc agggagttat acatgtggac agccatcctg 1353001 aaaaaggcac agcgtttaaa atttcatttc caaaaaaata aaaacaacgg cttaaacgcc 1353061 gttgtttatc gtctgcattg cttcacgttt ttttaataca aataattcta aacggtctag 1353121 gccttctctc agcgtgtcca ttgagcatgc aaaagacagc cttacatatc cttcaccata 1353181 tgttgagaac gagctgcccg gcacgagtgc cacgccagcg tcttccaaaa gagccatact 1353241 aaaatcaaat gaagtcattc caaatgattt aatagaaggg aagatataaa acgcaccgga 1353301 cggtttaact acgtcaagtc ccatggaaac aagacggtca taaacatagt ccagacgttt 1353361 tttgtattgt tctctcataa tcaatgcatc gtcaaagccg tttgtgacag cttcaagcgc 1353421 ggctttttga gaaatggatg aggcgcacga cacattgtat tgatgaacct ttaaaatgtg 1353481 ctttgcaatg tctttcggtg caaataaaaa tccaattctc caaccggtca tgctgtgtga 1353541 ttttgacaac ccgttaatga caatcgtttg atcccgcaaa taggttgcga tggagtaatg 1353601 cggtctgtca tatgttaatt cactgtatat ttcatcagac aatacgaaga catttctgcc 1353661 ttttaagaga gctgcgatgc ttttcagttc ttcttcagat aaagtcacgc cggtagggtt 1353721 tgacggataa ggaagcacga cacacttggt gttgggtgtc agagcatctt caatcagccg 1353781 ggcggtaagc ttaaagccgt gtgacgtagt atcaacaatg acaggcttgg ccccgcacaa 1353841 attgataata ggttcatagc ccggataaat aggccctggc ataatgactt catcaccggg 1353901 agataaaatc gtccggaatg cagcatcaat ggcttggctt gcgcctgttg tgatgataat 1353961 ttcagattca gcatcatagt tgaaatccgc ttttttcttc atataaagct gcacagcttg 1354021 tctcagctcc aggtagccgg cattcggagt atatgacgtc acgttttcat caatggcttt 1354081 ttttgcggca gctttcacat gatgcggtgt gaaaaaatca ggctggccga ttgtaagtga 1354141 aatgacgtct tcgtgttggg ctacaagatt cgagaatttg cgtattcctg aaatttcgat 1354201 ctctcttgct ttcggattca gcaaatgttc cataattcat caccttaaca aatataatga 1354261 gtttatccta ttttaccact agctgatcat ttgtcacctt tttaactgat atatttcgat 1354321 tgtatgcgcc ttttttctaa acataccttt cttttcagaa aaaaagaaga caaccagcga 1354381 tttgattgtc tttattgtat catgttctat tattgtttat atgtgccaat ttcattaata 1354441 gccataatca aaatgaaggt cttcgtgcca aatcagatac ggaggatgct cttcttgaag 1354501 gtcagctgat tctttcttca tattcaggta agtttcttca ctgatatcct ctaaaacagt 1354561 catttcgttt tctttaaata ttactaaggt acccattatt tacacccttc tttggaaaaa 1354621 tccttgacta ttttatcact gttagttgga aagtcaatgg ttattaggaa aaaagtttct 1354681 tttttgagga acgcggcttg ttgccttcgg aattcgattt tgaagagctg ccattcactt 1354741 tttacaaatt acgccgatat atacagtaca atactgaatg cgaatagcga gggattgaat 1354801 tgtcgttaca acaatacgaa attttattgg attctggtac aaatgaatta gaaattgtga 1354861 agtttggcgt gggtgaaaat gctttcggaa ttaacgtcat gaaggtaaga gaaattattc 1354921 agcctgtcga ggtgacatca gtgcctcact cccatcagca tgtagaagga atgattaaac 1354981 tcagaggaga aatcctccct gtgatcagtc tcttctcatt ttttggagta gagcctgaag 1355041 gatcaaaaga tgagaaatat atcgtgactg aatttaataa acggaaaatt gtttttcatg 1355101 tcggctctgt ttctcaaatt cacagagtat cctgggaagc gattgaaaag ccgacatcgt 1355161 taaatcaagg aatggagcgg caccttaccg gtattattaa gctcgaagac ctgatgatct 1355221 ttttgcctga ctatgaaaaa attatttatg acattgaatc agattcaggt gttgacacgt 1355281 ataatatgca taccgagggc ttcgatgaaa gaagaactga taaaaagctt atcattgtag 1355341 aggactcacc gcttttgatg cgcctcttgc aggatgaatt aaaagaagca gggtacaaca 1355401 atatcgcttc gtttgaaaat ggaaaagagg catatgaata cattatgaac cttgctgaaa 1355461 acgaaactga tttatcaaaa cagattgata tgatcatcac tgatattgaa atgccaaaaa 1355521 tggacggaca caggctcaca aagctgctga aggaaaatcc gaaaagctca gatgtgccgg 1355581 ttatgatttt ctcatcgtta attacggatg atctgcgtca ccgcggcgaa gttgtaggcg 1355641 cagatgagca aatcagcaag cctgagatca gtgatttgat taaaaaagtg gatacgtatg 1355701 ttattgaata aataaaaaca gccgttgcca gaaagaggca cggctgtttt tattttaaaa 1355761 gtaactctcg ccaagttttt taaagaccgg tttatggtaa gctggctgct ggcgatttgg 1355821 cactagcggc ttttctttca tgccgacata ttcttgcaat aggtgtttcg cttttgttaa 1355881 agacatttga gctttaggat ttcgatacga ttgattaagt gtacctaaat gcggaagatg 1355941 ttcgaagtct tctttagttg gaggcatgtg aaaatagtag tctccgattg agataagcac 1356001 gtccgattgc tgttggctga accttggatt ttttgaaaaa tgaagcccta ttttctttcc 1356061 tttaccttct ttgacaagct tttgcaaagc ccgttttttc agcagatata ggtatttagg 1356121 gttgggggcg gtttttgcat ggcggttcac agtgtaaact gcttttgaaa gattttctac 1356181 ggttggctgc agatctttcg tatatgcatg gtcgtccatt atttctctcc tttgctctta 1356241 tcaatttcta tatgtttaga ttatactttt ttaaagttga aatgcaaata ttgaatgtaa 1356301 aaatgcgctt ttttctaaga aaaaaagcgc atttttaacc tgcattatac agatcttgcc 1356361 ttctttttcg gctgttcttg aaatgcttcc tgaacattca cttccacagc ctgagcactg 1356421 tattttggca gtgcaataaa ataaaaaata aaaacgagca ggataataac acccatgccg 1356481 taataaagat aatcaatgtt tgaaacaaac ttagggaata acagcgcgac taagccgagt 1356541 gtcaaagatt gtgcaaacat cataaaaggg tcctgcatgc cgcttacacg tcccatcagt 1356601 tttggatgaa caatttttgg catccaccct ccgattgcaa tgttgatcgg tccgatacac 1356661 attcccagtg caaaagctgc cgcgtaatac acccataaaa tattggtgta gccgaggacg 1356721 aagatcagca aacctgcaat gaaaatcggt atcgacatta aaaagtgcgg cttcactttt 1356781 ttagagatga gcgtgccgat tacgcttcct gccagaagcc caaacccgag tgcgatcgta 1356841 aatacagacg tatgccactc ataacggtca ggcgccaatc catatttcat tgtaaacatc 1356901 ggcaatacgg cgaatcctcc attgacaaat ccaaaaatga agaagccaaa aataagagat 1356961 gccagcaatt tgttttttaa aatatagagg atgccttctc taaagtcatt tattgaatcc 1357021 ttaacagaag tctttctcca gctgaatgca ccgtttggct gtcgggcttc ttttggaatc 1357081 cggcagctgc ggatcagcag cccggaaatg ataaagctga caaaatcaag aataatggcg 1357141 ccttcaatac cgattgtgtt gtacataaac gcgcctatgc cgactccaaa caccataaaa 1357201 atgctaaaaa gcatctgatt aagccctgcc gctttcgcat aatgctcctt cggcagaatg 1357261 gcttgtacca aactgttttc tgccggaaag aaaaactttg ttacagcgct tctgataaat 1357321 aagatacaaa aaacaagagg aatattgccg gtaaataaag tgaaaaaaag cacgacagtc 1357381 aggcctgctc tgatccaatc acaattttct gccacctttt ttctatcaaa ccggtccgcg 1357441 acgactccca cgatcagaaa tacaaatatg gtcggaagag aatacatcag ctccgccaag 1357501 gtcgtatatg aaggctggct gctgaatcgg tccagcaaaa aaaaagcaaa ggccatgttg 1357561 cctactgtcg tgcccatttg agaagcgagt gctgcgaaaa atagacgaac aaaattacga 1357621 tttttaaata tatccataaa aacgctcctt accctaaagg tcccacttta tcatattata 1357681 aaccgcctgt ttttgaaaca aataagaaaa cattaccggt taatcgtgac tctcgttccg 1357741 tttggcacaa ttgaagcaag ttcgatcacg tctttgttat gcatgcgaat gcagccttta 1357801 gaaacagcct taccaatcga agcgggatta ttcgtcccat gtattccgta gtgctgcttt 1357861 gaaaggctca gccaataagc gccaaatggg ccgccgggat tgcgctggcg gttaataatg 1357921 taaaactcgc cagtaggcgt ttgcgttagt attttaccaa cggcgatggg ataggttttc 1357981 attacccgat tatttaggga cagcgtaagg gtcttcgctc cgattgagac tgcgatatga 1358041 tacggaattg tataagggtc cggcagtccg gggatgacta tggactgtcc cgcggtgagc 1358101 cctgcctgca gtgacggatt agcctggagt aatgcagccg tgctgattct gaaatcagcc 1358161 gcgatgctgt tcagtgtatc accttgcttc acctggtacg taagcagttt cctcatcctc 1358221 cttttttact tataagtatt gatgaggagc ccatcctgct acattaattt gtgcttttta 1358281 aggtgaagac agtgatttca ggcttggcaa gaaaccgcaa aggcagcctg gtcatcccga 1358341 ggcctcggtt tacgtaaata tgagtgctgc ccgtttgata cattccctct gtgtagactt 1358401 ttccatatgg aggcgtaata atcggtccgt aaaaaggcag ctgaatctgg ccgccgtgtg 1358461 tatggccgga aagctgaagg ttcacgggat aatctgttgt tttcaaggct gcatcaggtt 1358521 catggacgag aagaatggaa aaaagtctgt cgctcagcct tgaaagggtg ccttcataat 1358581 ctgggtttcc cagcattaag tcatcaagcg aagcaatctc gattttgctg ccatctgcga 1358641 gtgacaatgt ttgatagcca ttgcgatata ccgtgaaacc tccggccgtc atcaggcttt 1358701 tgtaaacggc agttccatag cctccgtgat catgattgcc gtaaatacaa agcttgccga 1358761 agggagcatt aagctttctc aataatggaa tgactgcctg gtggtgctgg tacgtatcag 1358821 gattatcaat aatatcacct gtaaaaacaa tgagatcagg tttagattca ttaattgtaa 1358881 gaatgacagt ttttaaatct tcgagagtaa agtaatcact caagtgtgca tcgctgaact 1358941 gcacgatttt aaaaccgtca aatccgtgcg ggatgagaga gctttttatt gtgtgttcgg 1359001 ttgtctcgat catatgcggc tcgagatacc tggcatagcc atatcccccg ccggccgtta 1359061 aagccccggc agcaagagcg ccgaacattc cttttagaaa ttgtcttctg gacatctttt 1359121 tcatttcaaa ccaaccttta atagagtttt tctattatat catctgtatc tgataaaaat 1359181 ctcatatgag catgtgctga cagaggcagg gatataatga tagaatatta ttgaatgaat 1359241 aatcattcac aattggaggg ataaacatgg aaaaaaaggc ggtaattatt accggcgggt 1359301 caagcggcat gggaaaagcg atggcaaaaa aacaggctga attagggtgg cacgttatgg 1359361 tgacagggag gaaccatgag gcacttgagg aaacaaaaaa agaaattcag acctttgagg 1359421 gacaggtcgc ttgttttcaa atggatgtcc gttccgattc cgccgcttca gacatgatta 1359481 aagaagcggt aaaagccttt ggccggcttg acgcgctgat taacaacgcg gccggaaact 1359541 ttatttgtcc ggcagaaaag ctgacgccca atggatggaa agccgttatt gagattgttt 1359601 taaacggcac atttttttgc agccaagcag cggcaaggca ttggattgac cagaagcagc 1359661 agggtgtcat tttaaatatg gcagccacgt acgcttgggg agcgggagcg ggggtcgttc 1359721 attccgctgc agccaaagcg ggggtattgt cattgacaag aacgctggcc gttgaatggg 1359781 ggagcaaata cggcattcgt acaaacgcga tagcccccgg accgattgaa cgaacaggcg 1359841 gtgcggagaa gctatttgaa tcggaaaaag cgatggcccg cacgatgaac agtgtgccgc 1359901 tcggccgatt gggcacaccg gaggaaatcg ccgctttggc agcgtttttg ctttctgatg 1359961 aagcatccta tataaacggg gattgtatca caatggacgg ggggcaatgg ctgaatcctt 1360021 atccgtttta atctgaatat ttataagtga atatttaagt tattaagaac ttttatgttc 1360081 gaatgtaata cctccacaat taaccttctt cctatccaat ttgataacac atagagcttt 1360141 atttgtttat gaggtgttgt gtcatacgta agccacctaa tatatgaaag gtatatttta 1360201 aaaggggaga cgaaatatga agaacttaga tttcaaataa aacattcata taattacttc 1360261 gttaactaaa aagagaaatt ataagaatga aaggtttcaa ggttacatca gattgggagg 1360321 aaggtaatat aatggacgag atggtattat taactcagga atggctcaat gaaacgtaca 1360381 aaggaaaaag tggctacaat tccattgagg aaaatgggaa aactggctgg aaaacaatgt 1360441 atgcattaac tagagcatta caactagaat tgggaattac acagacttcc gacagttttg 1360501 gtcctacaac tttaagaaag cttaaagaat taggcccgat ttctacgtca actaattcaa 1360561 aaaaaaatat tgtgaaaatt attcaaggtg ctctttattg taaaggttat ggtccaggtg 1360621 gattaacggg tacatttggt cagggaacga aagaggcgat agcagaaatg caattgcata 1360681 tggggctttc taaaacagac ggtgtagtaa cgcctaaggt gtttaaagct ttattaaaca 1360741 tggactctta tatcctttta aatggggcgt cagagaaagt tcgttcaata cagcaatggc 1360801 taaataataa atattacaat agagagaatt tctactttat gccctgtgat ggcctgtatt 1360861 caagggatac tcaaaagtct cttgtttatg caatacagta cgaggaaggg ttaagtgata 1360921 gtatagctaa tgggaatttt ggaccaacta ctcaaagatt gattcctgta ttaagaattg 1360981 gagaaacaga tgaaaaaaac agttttattc atttatttca agctgctcta atctttaatg 1361041 gctacaatgt tccttttgat ggagtatact ctgaatctgt aagatcaaaa gtaaaggctt 1361101 ttcagtcttt tgcaaaatta caacagagtg gtactgccga ctttcaaaca tgggcttcac 1361161 ttctagtaag tactggagac cccaatcgaa aaggagttgc ttgtgactca attactcaaa 1361221 ttacatcgga cagggcggag tcccttaaga gggcaggtta taagattgta gggcggtatc 1361281 taacaaatgc gccggggagt acactaaata aaaaaataca accaggtgaa ttagaaacta 1361341 tcttaaaatc aggtttaaat gtttttccga tttatcaaac ctatggggga gcaacaaatt 1361401 attttaataa agaacaagga aagaaagatg cgtttgctgc ttataaagca gcaaaagaat 1361461 acgggtttaa aaataacact gtaatatact ttgcagtaga ttatgatgca tatggtaacg 1361521 atttaaacaa caatattatt ccacacttcg aaggtataaa tgaaataatg aacggttttt 1361581 taggttcaac ttacaaaatt ggtatttatg cccctaggaa tgtatgtact atagtttcta 1361641 aaaaaggttt agcatttgca agttttgtaa gtggtatgtc tactggcttt agcggaaact 1361701 taggatatcc tttgccttac aattgggcgt ttgaccaaat ttcaacaatt actgttggaa 1361761 atggttctgg aatgattgaa attgataatg atatttgttc aggtttggat aatggagtta 1361821 ataccataaa tatagtgcct tcagagaata agaagttttt tgatcaaatt gatgttttat 1361881 atgaaactgc tgaaaaatat gctcaaatgc aaagcgactt aaataatggg gtaaaaaaaa 1361941 cacaattagc taatgagttg gttgcccagt atttaagaaa ggatgactac aaagggtgga 1362001 agtgggtccc taccgcaggc cagattgatc ctatttatcg tgaatgggca gtaaagcgct 1362061 aggggaagac ctagtaaatg gaattgttga tcctatatca aaaactgtca taggaacgca 1362121 gcatcttatg gcaacttata atgccattat ttatagtggt ggttactctc aaacactacg 1362181 agattttgct ggttggactg gagatctatt aacaacaata caggacatga aattacacgc 1362241 tcaagaattt aattcgcctt atgatgcggc tatgaaaata ataggtaata tgtatcaatt 1362301 tagcctagat gatttattta gtgatgtaga tgcaattaat ctagcgaata aaacatcagt 1362361 tggtgctaat gcacaacctc taaatatcgc aattagagat tattatagta ataatgactg 1362421 tatgaatagg ttcactcaat ttgtaaataa tagatttgat ggttcgttag acaaaatttt 1362481 ctctgaagca gagtattatt taaatacaaa ccttgaccca gttgttgttc caattaggtt 1362541 agcctttaaa cgtgcttttg atgttgagga ttatagtgaa gagattggaa aaataacagc 1362601 acaagcattt agagatgtta tcgagaaaaa aatgatatct gaataaactg caaaacaagc 1362661 gaacgttaaa actggtcgtt cgcttgtttt attttctatt taaatttatg atataatttt 1362721 taaagattaa ggagtgattc attgaagaaa ttgttaaaaa agttagttgt attattttta 1362781 agcagtttag ttatcatctt taatgtttgg tactttatta tttgtgcttt ttccccagag 1362841 tattatcaaa atacaaatct tacttctaat gaaataataa gatttgaaaa actataccac 1362901 atagattttc ctgatgaaac aaaatttatt aaagctagag agtatttggc tgggcccgga 1362961 ggagatacgt cagctgtatt atatgtgtct ctgccaacca agcgggtaga aaaagtttta 1363021 tctgattaca cgtatatgaa aataaactat actgacaatg tcggttcaat gtatggagtt 1363081 gacgtttcaa agagtgtcgc cggtttaaca actcttacat ttggcactta cgataaaaaa 1363141 ggaactttct ataatatgaa acatgatgat gattggatgt ataaaggcac tgactggaat 1363201 ctttactttt ggacagctgc tagttataat gctgttattt ttgtatttgt tttggttatt 1363261 gtgaaacaaa tgaataaaat tcttaattaa ccagtatgta gattgataat ctcaaaaaaa 1363321 ttttcctctt cttttaacat actccatacg acctactttt ccatactatg atttttttga 1363381 aatttgtggt gtagttataa ttgtgcgtat aatcagacaa agatagagaa gcaggtgata 1363441 acatgttgga tccacttgat attttaacga acattgatga tgtccttcca tattaccagg 1363501 cgatttttag tgccgaggag cagaaggttg tcggatatga ggtgcttgga cgaattttgg 1363561 cagattcaga aatccaaagt ctcgggccct tctttttaga tgcggggata cccgaagaat 1363621 ataaattaga ggttgataac agaattatcc gccaggctct tgaccgcttt ttagaggcgg 1363681 attctgatct gctgattttt atgaatcagg atgccaatct gctgatgctg gatcatggtg 1363741 aaagctttct ggagcttctg aaagaatatg aagcgaaggg aatcgaactc caccgttttg 1363801 tgcttgaaat tacagagcac aattttgaag gggatattga gcagctctac catatgcttg 1363861 catactatcg tacatacgga attaaaatcg cagttgacaa catcggaaaa gaaagcagca 1363921 acttggacag aatcgcgctg ctctcaccag atctgttaaa aatcgatttg caggcgctga 1363981 aagtgtcaca gccgtcaccg tcatatgagc atgtgctgta cagcatatct ttattagcaa 1364041 gaaaaatcgg tgcggcgctg ctgtatgaag acattgaggc gaacttccag cttcagtacg 1364101 cctggagaaa cggaggccgc tattttcagg gctattactt agtgtctcca tctgaaacgt 1364161 ttctagagag agatgtattg aaacaaagac ttaaaactga atttcaccaa tttatcacac 1364221 atgagaaaaa gaaactggag accgtctatg agcactctga acagttttac aaacgagtgc 1364281 atcaggctgt gacctctttg agaaaaaaca atctgtcttc tgatgatgac tttattaaaa 1364341 agctggcgga agagctgaca gattgcagct tcaggattta catgtgtgat gaagaaggcg 1364401 atcagctgac gggaaatgtg tttaagcaag atggagaatg gatttatcag ccggaatatg 1364461 cggaaaagaa ctggagctgg cgcccttatt ttctggagaa cattatgaga atgagaaatc 1364521 tcagaaaagg ttttttcagt gatctgtaca gtgatttgga aacaggtgaa atgatcagaa 1364581 cgttttcata tccgatggat gatcagatgt atttatttat agacttgcct tattcttatt 1364641 tatatgagca ggacggactg atttaacggc tgaaaggccg ttttttttat gaaatgaaaa 1364701 aaatatcaaa aaacgattga cattgatact gagaatcatt atcatttaat tatagagaga 1364761 agctactctc tgttccccaa cccctctatc agatcaagat ccgaaaaaac ttggcgctac 1364821 ccccgccaag ttttttattt gtcaaagcat aggacaatcc aatgaaacaa taaacctaac 1364881 tagtggtaaa cgtttaacac ggggagaaac attgagtgcc gaacacccct gacactgctg 1364941 cacgggtgag gaggaaaatt cgttctgaaa tgattatttc agttccgttg tttacctcta 1365001 tccagcatga ctcccattga ttatggccac gcgggacttc accataaaat tcaaaagaag 1365061 gttttgacaa agttgcaaaa aggcattctt aatgctgcca aagattcgaa aaaaattata 1365121 attatgtgca tgacattcaa aaaaagcctc aaactaaaga aaaatagttt ttttcacttt 1365181 ttttctttgc ttaaattcag cagtgaaaat gccatcctgt ccgactttat ggtatgatgc 1365241 tcaatagaac ttgtattata ataaatactt gttgatttga agttgctttt tgaaaggagt 1365301 ctttttttag aatgtcacaa ttaatgggta tcatcacacg gctgcaaagt ctgcaagaaa 1365361 cagcggaagc ggctaacgag ccaatgcagc gttatttcga agtgaatggt gagaaaatat 1365421 gcagtgttaa atatttcgaa aaaaatcaaa cgtttgaact gacggttttc caaaagggtg 1365481 aaaaacctaa cacatatccg tttgataata tcgacatggt ttccatcgaa atctttgaac 1365541 ttcttcagta agattcctga aataggggga acaagcttcc gcctttgcaa aagtaatcga 1365601 aataaacggt aaggaacata cttgtttcat ggttgtaaat ccttgaaaag gagtgtcgtg 1365661 atggctgatt cttttctgtt ttataatctt tcagaagcac agatgacctt tcaagatgtg 1365721 atggaacggc ttaaagcctt tgttcaaaag gacccccgtt cttcttatgt gttatcgatc 1365781 ggaaccgatt cacaggttta ccgcgattac acaaagttta ttaccgcatt gcatttgcat 1365841 cgtacaggca agggagcttg gggctgcttg aaaaatcata cagtcgacag acccatacat 1365901 agccttcggg agaagatttc gttagaaacg gcgtacagcc aagaaacggc cgctcatatt 1365961 cttgatggac acttaatgga tattaccgat ctgctcctgc cctttaccgg tgagggggcg 1366021 gatcttacct ttgaagttca cttggatatt gggaaaaaag ggcttacaaa agatctgatc 1366081 caagaaatga ctggacgtat tacctccatg gggattgagg ccaaaataaa gccggattca 1366141 tacactgcct tcagctatgc aaatcgtttc acaaaataat ttggctgaaa aagccaaggt 1366201 aaatgtcgaa ttatgcggtt gacgtttgtt atctgattac ttattctagc ggtagagctg 1366261 aaagtaagtt gtcttgcttt cagaggtatt cagtataaaa cagggggcct gattgcgaat 1366321 gagtcttatc ggtgaacgat ttacagaaga agaacaaaaa cttctgctga atatcctgat 1366381 caaccatgag tatgccatcg agctattaag cagtgagatc aacgatatag agacagggac 1366441 caaaaacgtt gacggaacca cctacaaaaa acttgtaacg ctatacgacc gatttcgatt 1366501 tgaaaattaa tgggacaccc tataattgat actccacaaa gagtatcttt tttattgaaa 1366561 ggaaactttt cgacaaatac tgataaagtt tatattattg caatataggg aatgtattga 1366621 tgatgaaaat gaaaaggggt cgaaaacatg ataagcttac aatcagatca acttcttgag 1366681 gcaacagtcg gacaatttat gattgaggcg gacaaagtag cgcacgtgca agtcggaaat 1366741 aaccttgagc atgcattatt agtattgaca aaaaccggat acacagccat cccggttctg 1366801 gatccttcct accgtttaca tggcttaatc gggacaaata tgatcatgaa cagtattttt 1366861 ggacttgagc gaattgagtt tgaaaagctt gaccaaatca ctgttgagga agtcatgctg 1366921 accgacattc cgcgccttca tatcaatgat ccgattatga agggattcgg catggtcatt 1366981 aataacggat ttgtctgtgt tgaaaatgac gagcaggtat ttgaagggat ttttacgaga 1367041 agagtcgttt taaaggaatt gaataagcat atacgctcat tgaataagta ggctgtacgg 1367101 tcctattttt attatatagg cagagtgaaa aaagaaagcg catacataat ttaaacgaga 1367161 atagggcttg aataagaaac taagatttta ttagaatggg agataagaaa aacttattga 1367221 taacaaaaag gaggacgaca tgcagcttca agagcttcat atgctcgtag ttttagctga 1367281 ggaattaaat atgagaaagg cggcagaacg gctttttgta tctcagccgg ctttatctca 1367341 gcgcttacaa accattgaaa aggcgtgggg aacaaaaatc tttttaagat ctcaaaaagg 1367401 attaacggta acgcccgccg gtgagaaaat cattcagttt gcgaatgatg tgacattaga 1367461 gcaggaaaga ataagagaaa atattgacga gcttgaaggt gaaattcacg gcacattgaa 1367521 gcttgccgtc gcctccataa tcggtcagca ttggctccct aaagtcctga agacgtatgt 1367581 ggaaaagtat ccgaatgcaa agatctcgct cataaccggg tggagcagcg aaatgctgaa 1367641 aagcttgtat gaggatcagg ttcatatcgg cattataaga ggcaaccctg agtggaaggg 1367701 gcgcaaagat tacttaatga cagatcatct gtatttagtg gatactgaaa tttcctgcat 1367761 cgaagatatt gcccatacag aacgtccgtt tatccagttt aaaagtgaca gcacttattt 1367821 tcaggaaatt cagcactggt ggcatcaaaa atttaaaacg tcgccgaaac agacgatatt 1367881 ggttgatcag attgaaacgt gcaaacagat ggcgctgcac ggaatcggtt atgccatttt 1367941 gccgtctgtt acccttcaaa atgaagataa agtgaataaa atgcctcttt tagacatgaa 1368001 agggcatccg atcggtcggg atacatggtt attaggttat gagcctgcct ttgaactgaa 1368061 acaagttcaa gcttttgtac aagtgataaa ggatatgctg gatcaggaaa atccatttta 1368121 aagacagcga ggtgctgtct tttttttatt tatctgttga caatgaaaat cattatcatt 1368181 taaagtgata catatgatat tgaaaatcat tatcaactaa tggggtgata acatggctaa 1368241 agccttgatt acatatgcca gcatgtcagg aaatacagaa gacattgcct tcataataaa 1368301 agatacgctt caggaatatg agttggatat cgattgtgtc gagataaatg atatggatgc 1368361 gtcttgttta acctcctatg attatgtact gattggcacc tatacatggg gggacggcga 1368421 tttgccctac gaagcggagg attttttcga agaggtcaaa cagattcagc ttaatggttt 1368481 aaaaacagcc tgcttcgggt ctggcgatta ttcttatcca aagttttgcg aagcggtgaa 1368541 tttgttcaat gtcatgctgc aagaggcggg agctgctgtt taccaggaaa cactaaaaat 1368601 tgaattagcg cctgaaacag atgaagatgt ggaaagctgc cgagcgtttg cgagaggttt 1368661 tcttgcatgg gcagattata tgaacaagga aaaaatccat gtttcataaa ggggcaaccg 1368721 ctgttacggc atcggcgttt tctggatatt ttgtggcggt acaaagagaa ggcatttttc 1368781 attactcttt ggagcagggc tggagaaagc tttttcgttt gaaaagtaag atacactgta 1368841 tcagctacat agggccttac ttatttggcg ttggtgaaaa gggaacagtc attcgttcgg 1368901 ctgatgaagg gaaaacctgg acgatgtcga gctttccgac aaatgcaaca gtgtgggcga 1368961 ttaccggcag aaacaacggg tttgtctgcg cccacggtaa gcattgtatt tatgtatcgg 1369021 atgattttgg tgtctcatgg cgcgtagcca aaccttttgc cgaatttcat aatccccctg 1369081 ttatccggtc gttatgcctt cacgggggca atctctttat cggcacgcaa atacacgaat 1369141 attttggcgg catttgggct tacgacatta agcgtgacac tgtccaagtt gtcaaaaaag 1369201 aaaaaaaccg gatgacggca tccatgctcg tgttcaatga aaattggctg gtggcggcga 1369261 tgggttctgt gaaaggaaag cacggtgctg tcactgtaag gaatcttttg aatggtgaag 1369321 aattcaccat acaatccagt atgatcagaa atgaagaatc atttcttgat ctttcagagg 1369381 atgatggcat tatatatgtc actacaacac aagatgaaaa tggtttttcg agaatttacc 1369441 aggttgatct cgaagcccgg tcgttaaaat ggttcgatac cattaaggga catggatgga 1369501 gagtggccaa tcagaaagag aatttctttt gcgcaggctt gtatgaatgt aaatttgtcc 1369561 agccgtacga agtttcagca atgattcatt agaggaggaa caaggaattg gcgaagattt 1369621 tgctcgttta tgcaacaatg tcaggcaaca ctgaagctat ggcagatttg attgaaaagg 1369681 ggcttcagga ggcgttagca gaagtagacc gtttcgaagc aatggatatt gatgatgccc 1369741 agctgtttac cgattatgac catgtcataa tgggaaccta cacgtgggga gacggagatc 1369801 tgcctgatga atttttagat cttgttgaag acatggagga gattgatttt tccggcaaaa 1369861 catgcgctgt attcggttcc ggtgatacag catatgaatt tttctgcgga gcggttgata 1369921 cgctagaggc aaaaataaaa gaacgcggtg gagacattgt gctgccttcg gtaaaaatcg 1369981 aaaataatcc agaaggtgaa gaagaggaag aattaataaa cttcgggaga caattcgcaa 1370041 agaaaagcgg gtgcgctgtc tgatcactca ctgggaactg ctaaaacggc tgttcctttt 1370101 tttcttgtct ttgtatcttt cctttgatac agtaatgagg tagaaaatca ggaggaggac 1370161 tatacatatg aaaatgatgg acgcaaatga aattatttca tttattcaaa atagtacaaa 1370221 atctacacct gtaaaggttt acgtgaaagg tgagctggaa ggaatcaatt tcggtgaatc 1370281 tgcgaaagct tttatcaatg gaaacactgg tgtcgttttc ggtgaatgga gcgaaatcca 1370341 aacagcaatc gaagaaaacc aaagcaaaat cgaagactat gtggttgaaa atgaccgccg 1370401 caattctgcg atcccaatgc ttgatcttaa aaacatcaaa gcgcgtatcg agccgggtgc 1370461 gatcatccgc gaccaagttg aaatcggtga taacgcagtc atcatgatgg gtgcttctat 1370521 taatatcggt tcagtcatcg gcgaaggcac aatgattgat atgaacgttg tgcttggcgg 1370581 acgagctact gttggaaaaa actgccatat cggcgcgggt tctgtacttg cgggcgttat 1370641 tgagccgcca tccgctaaac cggttgtgat tgaagacgac gtcgtaatcg gcgcaaatgc 1370701 tgttgtgctt gaaggtgtaa cagtaggtaa aggagctgtt gttgctgcgg gagcgatcgt 1370761 ggtaaacgac gttgagccat acactgtcgt tgcaggcaca ccagctaaaa aaatcaaaga 1370821 cattgatgaa aaaacaaaag gcaaaactga aatcaagcag gaattacgcc agctgtaagg 1370881 aaaagtttga taaaaaaggc gtggataata tatccacgcc ttattcgtat aggcaggagg 1370941 aatagaaatg aagatagagg agctcatcgc aattcgcaga gatctgcatc gtataccgga 1371001 gcttggattt caggagttca aaacccagca gtatttatta aatgtcttgg aacaatatcc 1371061 gcaagacaga attgaaattg agaaatggcg aacagggctt tttgtaaaag tgaacgggac 1371121 ggcgccggaa aaaatgctgg catacagagc ggatatcgat gcgctttcta tagaagagca 1371181 aactggtctt ccattcgcat cagagcatca cggcaacatg cacgcctgcg gtcacgattt 1371241 gcatatgaca attgcactcg gcattattga tcattttgtt caccacccag tcaaacatga 1371301 tttgcttttt ctgtttcagc cggcagagga agggcctggc ggtgcggaac caatgcttga 1371361 gagcgatgta ttaaaaaaat ggcagcctga tttcatcact gcccttcata ttgctccaga 1371421 gcttccggta ggcaccattg cgacaaaaag cggccttcta tttgcgaata catcagagct 1371481 agtcatcgat ctggaaggca aagggggaca tgcggcatat ccgcatttgg ctgaggatat 1371541 ggttgtagca gcaagtacac ttgtcaccca gctgcaaacg attatctcta gaaacacaga 1371601 tccgctagac agtgctgtta ttacagttgg taccattacc ggaggctcgg cacaaaatat 1371661 cattgcagaa acggcccacc tggaaggcac gatccgcacg ctttctgaag aatcgatgaa 1371721 acaagtaaag gaacggattg aagatgtagt gaaaggaatc gaaatcggat tccgctgcaa 1371781 aggaaaagtg acatatccgt ctgtatatca ccaagtttac aatacgagcg gattaacaga 1371841 agaatttatg tcttttgttg ctgaacatca actggcgaca gtaattgaag caaaagaagc 1371901 aatgactgga gaggattttg gctatatgct gaaaaaatat cccggattca tgttctggct 1371961 cggcgctgat tctgaacatg ggcttcatca tgctaagctg aatcccgatg aaaatgcgat 1372021 agaaacagcg gttcatgtca tgacaggtta tttttctgtt tatgccaatt aagtacaaat 1372081 gaaagaataa aattccataa aatgagcact ctagtaaacg gaggtgttca aaaatggcta 1372141 aaaaaattgg aattgaacaa tcgttatcag atgtagaagc tgctttaaaa gaaaaaggat 1372201 atgacgttgt aatgatgaaa agccctgctg atgctcaagg ctgtgactgc tgtgtcgtaa 1372261 caggtcttga taataatgtg caagggatag ccgatacggt aacacaagca cctgtcatta 1372321 cagcttccgg gatgacggct gaagaaattt gtagcgaagt tgagagcaga attcagtaat 1372381 aaaaaaaccg aagcaaaaag cttcggttct tttatttatt ctgtttcttt agggaaagcg 1372441 cggtcgaacg cgttctttat ttcttttctc aacactcgtt cgactcgcca ctgttccata 1372501 ttttctgttt tggcaatgac cctgattaca atttcagaag tccccagttc ttgaatcccg 1372561 atgacatttg ggccttcttt tatttgtgga agagccgctg ccgtttcatc acaaacctgc 1372621 tgtaaaatat gaatcatttc atcaatattt ctttcagccg gcactttaat gtcaacaaga 1372681 gcctgcatgg taccacgaga atgattgctc acgtttgtga tgtttctgtt ggggatgtaa 1372741 tgcagtgttc cgtcaaagct gcggatttga gttgtcctta agccaacctg ctcgacaatt 1372801 ccgtcaaagg tggaaacggt aatataatct ccgacatcca attgtttctc aagcaaaata 1372861 aaaaaacctg tcacgatatc actgacaagc ccttgggcgc caaatccgac agccaggccg 1372921 acgattcctg cccccgctaa aagagcgctt ggatcataat gaaacaaatc tagaaccatg 1372981 acgaaaaata tgaaaatcaa tgtataagca aatatgttaa gagtcaggct tcggagcgta 1373041 tgtgcacgtc cgatagacaa gctattctgc tcctcgaatt ttgcaaacag atgtttaatg 1373101 attttcatgc ctaatgatcg aacgataaaa tagagcaata tcataatggc gagtttaatg 1373161 agcagaacac cggcatttgt aatcagtccc gcccaatcat attgtttaat aaagtccatg 1373221 ttgagctcct tttctaattg attgctgcac attgagacta gttaccctgt acatgaccat 1373281 gttaaacgtt ttattcaaaa atgtcgaagc caaagacata catgatttgt taaaaattga 1373341 ctcaggaaat ctgcttttat ataatggcat tgcaatataa ctaaaaatgg ttaatcaccc 1373401 tttattttca tgcgattttg acctttaagc caaacaataa attggaggga tacatatggc 1373461 agaacgtatg gtaggtaaac aagctcctcg ttttgaaatg gaagcagtcc ttgcaagcaa 1373521 agaattcggc aaagtaagtc ttgaggaaaa catgaaaaac gacaaatgga cagtgctgtt 1373581 cttctatcca atggacttca cttttgtttg tccgacagaa attacagcaa tgtctgaccg 1373641 ctatgacgag ttcgaagatc ttgatgcaga agtcatcggg gtttcaactg ataccatcca 1373701 tactcattta gcttggatca atacagaccg caaagaaaac ggtcttggcc agctgaaata 1373761 cccgcttgct gctgatacaa accatgaggt atcccgggaa tatggcgttt taatcgaaga 1373821 agaaggtgtg gctttgcgcg gattgtttat tattaatcct gaaggggagc ttcaatatca 1373881 aactgttttc cataacaaca ttgggcgtga tgttgatgaa acgcttcgtg ttctccaggc 1373941 gctgcaaact ggcggactct gtccggctaa ctggaaacca ggccaaaaaa cactttaatt 1374001 ctttccaaga acgaaaagcg gtctagcata ttcgttaggc ctctctttta aaataggagg 1374061 gaaaaagcaa tgaaattacg tcagcccatg ccggaattga cgggagaaaa agcttggtta 1374121 aatggtgaag tgacgagaga gcaattgatt ggggaaaagc cgacgcttat tcatttctgg 1374181 tccatcagct gccacttgtg caaagaagcg atgccgcaag tgaatgaatt tcgtgataaa 1374241 tatcaagatc agctgaatgt tgtagctgta cacatgcccc gttccgaaga tgatcttgac 1374301 cctggtaaaa ttaaagaaac agctgctgaa cacgatatca ctcagccgat ttttgttgac 1374361 agtgaccatg ctttaaccga tgcatttgaa aatgaatatg tacctgcata ttatgtgttt 1374421 gataaaacag gacagctccg tcacttccaa gccggcggga gcggtatgaa aatgcttgaa 1374481 aaacgtgtga accgcgttct ggctgaaacg gaataggtat ctgactaaat agtatttcct 1374541 aaaaacctga cctcatcagg ttttttattt gtgcaaaaag caatggaaga agagtaagaa 1374601 gcttattttt ccaaatttgg gtataggaat tgatgatttg tttgattgat acgctaaaaa 1374661 acacagctaa tttttgatgt ttttcctcaa ttttagataa atctcatatc tcataactcg 1374721 aaaattgtag atattacact aaatttcttt aaagaagtaa gtaaaatata tattttcaac 1374781 attataccaa ataaactaga aagcccctta atcccttgag aataaaggac tcttttgaaa 1374841 aataaaacat tttcagaaaa taaggaattt ttcatagagt aaatataata gtaaaatgct 1374901 aaaataatag ttgataaaat tacttttgta atctaatatc ttaattaaag atgttaattt 1374961 tgataggggg tacattgagg aatgtttaat gaaagagaag ctttgcgctt gcggttagaa 1375021 caattaaatg aagctgaagt gaaagtcatt cgtgaatatc aaattgaacg tgataaaata 1375081 tacgcaaaat taagagagct ggacagaaat ggaagccctt ccgaaatcaa aaaggatttc 1375141 cgttctgaaa aaaaacctga ctctctgccg gttctcgctg agcttgcggc tcaggaaatc 1375201 agaagctatc agccgcaatc acagcagcag tctgttcagc ctcagcttca atctatttcc 1375261 tctcttcctg ccggtatacc agacggaaca acacgaagaa gaagaggaac ggcaagaccg 1375321 ggatcaaaag cagctaagct gcgtgaagct gctattaaaa cattaaaacg ccacaacgcg 1375381 gcgattaaga gctcggagct tcaaaaagag attgaaaaag aaagcggtct tgaaatccct 1375441 aatatgacaa cgtttatgca aagcttaatt aaaatgtacc cggaagtgaa aaagccatat 1375501 cgcgggcagt acattttaga gggtgaaatc gaatctgcag aatcagcaaa cgaataaata 1375561 taaagaaaaa ctgcttggca tcgctcaagc agttttttta ttgaggtttt ttctgtgaag 1375621 gtttgttttc tttttcaaga ttaagcttat acacccactt ttgataaggc ttttcttcag 1375681 cggctctgtt tttcagctct tcgattgtat ggctcttggc ctggtctgat gattgggcgt 1375741 gggcaagctg tttttgaagc acatgtatct gtttggtgac atcttcaagg atagtctcta 1375801 catgatttgg ctgcgcgtag gccgctggag cttcttcttc cgttttttct ttttgtttcg 1375861 tgccgccatc aatatcggca aaatgagaag caatccaggc atcgctttca tcaagttgcc 1375921 gtttatacga tataatagtt tcgtgaaata atttttcttt cgttttttct atgtctagca 1375981 gtctttcttt cgtttctatg attcgatctt tcatatgatc aacttctatt ttaatatgtt 1376041 ttagctgata ttctttttct accatttgct cttttagacg cccgttttcg gcttttatca 1376101 attcggcttg ctgttttgcc tgaagcagtg cattttgttc ctgctcaatt gaggcttgaa 1376161 gttcgctgat ccgtttatga agatttttat tttcttcttc gattttgact ttcgcaatat 1376221 gaagtttatg tttttcttcg atttcggctc tgcgtttata ggtttcagca gatagaagct 1376281 cctgcaaaac aacgatttta tcaagcagtt cagctcttat ttggtgcagg gtttggctgg 1376341 tgtgggaggc atgtttttct tttgttgaca tatgtgttaa ttcggcagac agctgctgga 1376401 gtttttcttt catatcggta ttttctttga gcagtttgtt atttttctga tgaaagtagc 1376461 ttgcttcaag ttcagaaatc agcttatggc accttgaaag ctcggatttt aaataaaggt 1376521 tctcctgaga cacgtcgtgg aaaaaaggac ctgatctttt cattcgaacc atctccctca 1376581 tgatgttaac actacaatat gcaaatactg aacagctatt cctctttaat aaacagacaa 1376641 gcagtagcgt tgagcctttg cttttgctat gcttttaacg aaactagagg tgagatgata 1376701 tgaagcatgt aaacgtactg ctggcagggg gagcctcacg tcgctttgga gaaccgaagg 1376761 cgtttgtcaa atggaagggc aggatgcttt acgaatgcgc taaagaggca cttggagaac 1376821 aaacggttat catcagccgt cccgaattta ttgatagatt tcaagaaaac ggtgaaaatg 1376881 aagtgtatca agatgctgag ccatttcaag gcatggggcc attggctggt atatataccg 1376941 cttttaaaaa gacagacggt gatctttata ctgttctttc ctgtgacaca ccgctgatac 1377001 aaagaaggac gatgctggag ctcaaacgtc tgatgattgc cggtgcggac gcggtagtcc 1377061 caatttcaga cggacaagtg cagccattga ttgcgattta ccacaaacgt atcatgccag 1377121 ttctatacga tcagctttct gagaagaggt tgagaatatc agatttatta ggcagaattt 1377181 cggtttgtta cgtacaggct gaaaatatcg gagcaaaccc ggcagagttt atcaacatta 1377241 atacacgtga tgattttagc tgtttggaag aaaaatcgaa ctccctcaag cgggactgac 1377301 ggggcaataa catgataaga tgacataaaa gataaggaga acaggtttga tggaggaacg 1377361 ttattcacgg caaatcagat ttaagcaaat tggggaagag ggccagaaaa gactggcaga 1377421 cagccatgtg ctgattgtcg gagcgggagc gctcggcact gcaggagctg aagggctttc 1377481 gagagcggga gtcggtacga ttaccattat tgaccgtgac tatgtggagt ggagcaatct 1377541 tcaaaggcag cagctttata cagaaagcga tgccaaactc cgcatgccga aagccatggc 1377601 tgccaaagag catctatcag cgattaacag cgagatacat attgaggcgt atgttaccga 1377661 aggaacagcc gaaacgcttg agccgctgat tgaaaaagca gatgtcgtga tcgacgcgac 1377721 agataatttt gaaacccgca tgctgataaa cgatcttgcc cagaaaacaa agacaccttg 1377781 ggtctatggc gcctgtgtaa gcagccaggg aatgttcatg actgtcattc ccggagaaac 1377841 cccttgtctg tcttgtttgt ttgagcaaat tcctgtcggc ggggcgacgt gtgatactgc 1377901 cggcattatt ccgcctgctg tgcatatcgt ttcagcatat cagcaggctg aggcattaaa 1377961 gctgttaacc ggccaaaaag aagcaataca gcgggggttt gtgacatttg atgtctggaa 1378021 caattcgcat atgaagatta acgttaatca tgtacgccgt gaggaatgcc catcttgcgg 1378081 agctaatgcg gtatatcctt atcttcagga ttggaacaca ccaaaagctg ctgtactatg 1378141 cggccgtgat acagtgcagg taaggtcaga atcattaaaa agaatcccga aacaggagct 1378201 cattaagcgg ctgaaaacaa tcggcaaggt cgaggctaat gcgtttttgc tgcatatttt 1378261 ttacgaggat ttcagaattg tcattttcaa tgacggacgg gcactggtgc atggaacaaa 1378321 tgatgtgaaa gaagccaact ccgtgttggc aagagtgatt ggactgtaac aacaggaggg 1378381 gtcagaatgc tggagaaaag aacaccgata ccggtagacg aggcagttcg gcgtgtctgc 1378441 cattttcaaa aacaaggtga aacagaatgg gtggcgcttg aagacagcct tcatcggttt 1378501 ttagccgaag atataactgc ggatcaccac gtacctgcgt ttgaccgttc gccatacgat 1378561 ggttttgctg tcagagcgtg cgatacggca gaagcttcac gtgaaaaccc agttcggttt 1378621 gaagttattg accatattgg agcgggagca gtatctgaaa aagaacttgg cccgtttcag 1378681 gccgtgcgga ttatgactgg cgcgcaaatc cctgaagggg cagatgcagt cgtcatgatt 1378741 gaactgactc aagcctttga ggagaatggg aagtcattta tgtctttaaa acgccgcttt 1378801 cagacggggg ataatatttc aaaaacaggt gaggacgctc aaaaagggag tgttttactg 1378861 acaaagggca cccgggtgac accaggagtg acggctcttt tggcaacatt cggatacgca 1378921 tctgtgcctg tcgtgagaaa gcctgtagtc gggattatcg caaccggtac cgaattgctg 1378981 aatgtcagtg atccgctgga accgggaaaa atccgcaaca gcaatgcgag tatggtatat 1379041 gcgcaagcga tagaagcagg cgcaacaccg ctttatttag ggaaaatctc tgatgaactg 1379101 gataaaagct ttgctgcagt taaagaagcg atgaaaaagg tggacttcct gatcacaact 1379161 ggcggtgtgt cagtcggtga ctttgacttt ttgcctgcga tctatgaaaa actcggagcg 1379221 gacgtgctgt ttaataaagt tgccatgcgc ccgggcagcg tgacaacggt ggcgcatgca 1379281 aacgatatgc tgctgtttgg cctttcaggt aatccgtcgg catgctatgt cggttttgaa 1379341 ctgtttgtca aaccgataat ccagacatgg ctgctcaatg aaacaccgca ttcaatttgt 1379401 gcggaagctg ttttgaccaa ggattttccg aagccgaacc catttacccg atttgttcgt 1379461 gcgctcgtgc accatcagga agggaagctg ttggcgacac ccgttggctt agataagtcg 1379521 agctctgtca catcacttgc agatgccaat gcatttatta tcctgccggg cggtacgcga 1379581 ggctacgaat ctggcagaac ggttcaagtg ctgctcatca gagaagagaa tggaagtgaa 1379641 tggccttggt ccgtcctttc ccgatcgtcc aagttgtagg atttcaaaac agcgggaaaa 1379701 caacgtttat tgagcgcatt cttgaaaaag cctctgaaca gggagtccat ttgggctgcc 1379761 tgaagcacca tggtcacggc ggtgaaccgc aaacgctcac ggaaggaaaa gacacggacc 1379821 gttacaaggc ggcaggtgct gatgtaacag cggtagaagg tgctggtgtg ttacagctga 1379881 ctgcccgccg caattgggat ttggcacggc tgattgagtt ataccaattt ctcgaaacag 1379941 actgtcttct gattgaaggc tttaaaaaag ccccttatcc taaagtggtt atcctaagtg 1380001 aaaaggaaga tctggaagcg ctgcaagcag taaatataat cgccatcatc tatagaaaaa 1380061 aagagcatat gacagagcat cagggattac ccgtttttca tgcggatgat ccggttgccg 1380121 tggattttgt gctttcacag ctgaaggggg aatctgcata atggaacggt ttgagattac 1380181 gaaaacaccc attaatactg aaaacatcat caaaaaagtg gagaaacggg aagcgggagc 1380241 cattacaaca tttattggta cggttcggga atggacaaac ggaaaaagaa cggttcggct 1380301 tgaatatgag gcatatgaac cgatggccgt gcaaatgctt gctcaaatcg gcgctgaaat 1380361 cgaagaaaaa tgggaaggtg cctcagctgc gatcacgcac cgtataggtg tgctcgatat 1380421 cggtgaagca gcggtagtga ttgctgtatc ttctccccat cgaaaagccg catatgaagc 1380481 caatgagtat gcgattgaac gcattaaaca gattgtgccg atttggaaaa aagaaatttg 1380541 ggaagacggt gagcaatgga tcggcgacca gctagaaacg acagcttatc cgaacggaaa 1380601 accagaccta agcgagggag agcagcatga ttaaaattct tttatttgca gggcttgctg 1380661 aacaggccgg tacacaagca atagaaatag atatggaaca agcaaccaca gatgaaataa 1380721 aagcgagtct aaaagaacaa tacggtcttg aatctattga tacggctatg attgccgtta 1380781 acgaaagcta tgtaaaagaa aatacctctg tatcttcggg tgacacggta gccatcatac 1380841 cgccggtcag cgggggatga aaaccggacg gcatttcagc cgtccggttt ttctgtattt 1380901 cattggcata tccccaagta tcctcagcat acaatgattt tctgtaagcg tttattctac 1380961 atatgttact ccctataaag taagagactc actccataat tagactgaaa ttttgaaaaa 1381021 taatagaaat ttatttcggg tatcgatata gtgaagatga taaatgttgg aaaggtgctg 1381081 gatatggaga catttaaaag attaaaaatg tattattggc cgtacagaaa agtgtttatg 1381141 tggtcgcttc tagccatgct tttgatgact gcaattactg tcgtttatcc gattatcctg 1381201 caaattacga ttgatgagat cgtactggga cggcagtatc agcttgcggc gtgggtcagc 1381261 ttaggattta ttgcggtgat ggttttgaaa ggaatggcta ccttttttca tcagtattta 1381321 ggtgatatgt tcgggatcaa atccgtttat cggctgagaa atggtctgta tgaaaaactg 1381381 cagcggcttt ctttttctta ctatgataac gcgaaaacag gagatttgat gtccaggctg 1381441 actgctgatg ttgaagggct tcgttttttc ttatcatacg gtctcgctga gctcattcgc 1381501 ttcggcctgc tggtagccat cagcctgtcg gttatgtttt actattctgt tcctctcacg 1381561 cttgtgacaa tagctgttct gccatttctc gcggttgcgg tataccggtt tgacaaaaga 1381621 gtccatcccg ccttcagagg catccgcaaa tcgtttgcga aactcaatac aaaagttcag 1381681 gaaaatatca gcggcattaa tacggttaaa tctctttcca gggaagattt tcagatcagc 1381741 actttcaata aagccaatgc agaatacagg gcgcagtatt tacaaacatc atccatttgg 1381801 tctgcgtatt tccctttaat ggagttcatt ggtaacactt gtattgtagc tcttctctca 1381861 tacggcggtt acttggttat gcaaaatcag ctcaatcccg gcgagcttgt tgctttcttc 1381921 agccttgtca attatatgat gtggcccatt atgaacttag gttttgtcat caatatgttc 1381981 tctcaagcaa aagcgtcagg ggaacgcctg ctcgacattc tggaaaaaga agaagacatt 1382041 acagatcatc ctcatgcttt gcataaacaa aaattaaccg gagatgtcca tttcaaaaat 1382101 gtttctcttg catacggaaa agaacaaaca aacgcgctgt gcaatgtaag ctttgaggca 1382161 aacagcggga aggtaatcgg actgttgggc ccgacaggtt caggcaaaag ctcagtgaca 1382221 cagcttctca ccagatttta cagtcctgtt ggcggaatga ttaccattga tcacaaaccc 1382281 atcacagatt attcgttaaa aacccttcgc tccaatatcg gggtcgtact tcaagaatcc 1382341 ttcctgtttt catctacgat tagatcaaat atttcgtatg ggcggccgga tgcctcaatg 1382401 gaagacgtca tcgaagcggc aaaaagggcg caggctcata actttattat ggagcttcct 1382461 gatgggtatg acaccatgct gggagagagg ggaatggggc tttccggcgg gcagaaacag 1382521 cgtattgcca ttgcgagagc catctgcttg aacccgagca ttttaatatt ggatgatgcc 1382581 acaagcgcag tagatatgca aacggagcac agcatacagc ttgccttaaa agaagtcatg 1382641 aaaaaccgca caacctttat cgtcgctcac cgcatttctt cactgaaaca cgctgatgaa 1382701 attctcgttt ttaataaagg acgcattcgt gaaaggggaa cacatcatga gcttcttgaa 1382761 aaaggcggct actataaaaa gatttacgat ttgcaatacc gtgatgtcaa aatgattaat 1382821 gagccgcatg aggtcggata gggaggggcc aaatgaaaca agcgaaaaaa cagggggttt 1382881 tagagcgttt ctattactct tcagatgaaa tcattgaaaa gccgtttaac tgggctcaaa 1382941 tgtggcggct gctgagctat gtcaaaccat atcgaaaaac aattttgccg ctttcttttc 1383001 tcactgtatt gattggcact gctgtgaagc ttgtgatccc cattttgatc ggcgtttatg 1383061 ttcttgatca agcgattaca gggagaaact cggagctgct gattcagctc atttttatta 1383121 ttagcggttt atatgtcctc aattacgccg ccaatgtgtt aagaatcagg tggatgaatc 1383181 agcttggcca gcatgtcatt tacgatttgc gacagcattt atttacccat gtgcagcgct 1383241 tatcccatcg attttttgat cagcggtcgg cgggatcgat cttagtcagg atcatgaatg 1383301 atattaactc tcttcaggag ctctttacaa gcggagtcat caatttgttg accgacttgc 1383361 tgcttctggc cggcgtgatt attattttgt ttacgctgag ccctgagctg actatagcca 1383421 tcatggtgac attgccgatt atgtttttta tttcaacaag tctcagaaaa aaaatacgcc 1383481 gatcctggca aacggtacgg ctgaagcaat cgaagctcaa ctctcatcta aacgaaagca 1383541 ttcagggcat ccgggtcacg caggcattta cgcaggaaga agaaaacatg gcgtattttg 1383601 acggtgtcaa tcaggagaac tacgaatcat ggcgggaagc aactagaaaa aatgccatgt 1383661 tccgtccgct tgtagaaatg acgaatgcga ttgggacggc tgtcttgatt tggtatggag 1383721 ccacactcat catgaatgaa accattacga ttggcgtctt cgtttctttt gctttctatc 1383781 tgggaatgtt ttgggaacct atttcgagac tgggtcaggt ctataatcag ctgttaatgg 1383841 ggatggcatc atcagaacgg atttttgagt ttctggacga acagccaaat gtcaaggaga 1383901 agccgaatgc cattcataat gaaaagataa atggggagat cagttttgaa gaggttgaat 1383961 tttcgtatga tgaaaaacga aaagcccttc acgccgtttc tttctctatt cctgcgggat 1384021 cgacgcttgc gcttgtcggg catacaggga gcgggaagac gacgattgcc aatttaatca 1384081 gccgttttta tgatgcggcc ggaggcacca ttaaaataga cggtataccg attaaggatc 1384141 tttcccttgc cagtctgcgc tctcaaatca gcattgtcct gcaagataca tttattttct 1384201 ccgggaccat catggaaaat attcgttttg gaaggccaaa tgcttcggat gaagaggtga 1384261 tgaaagcgtc ccaagcggtc ggagcggatg agtttatttc cgatttagcg gaaggatacg 1384321 caacagaggt agaggaaagg ggcagcgtac tgtctgccgg tcagcgccag ctcatttcat 1384381 ttgcaagagc attgctcgcc gatccggcta ttatcatcct tgacgaagca acggcaagca 1384441 ttgatacaga gacagaagta aaaattcagc aagcgttaaa aacgcttctg aaagggcgta 1384501 cagcagtgat gatcgctcac agattgtcta cgatccgcga cgccgaccgc atcattgttc 1384561 ttgatcacgg caggaaaata gaagaaggga accatgatca gctgctcgct aaaggaggca 1384621 tttatgccgg gcttgtgaaa gcgcaataca gcacagcgat agaataatat gaaaagcctt 1384681 caatattgaa ggtttttgga aatttattag aaaaacatga aactttttga tatccttccc 1384741 gtactatttg ttagatattc tcaaggaggt tttgaaatgg aaacgaatgt agaaaaaaac 1384801 agcggaacgg cgactgaaaa gccttcactt ttcggagtaa tcacaagtcc gtccgttcaa 1384861 tttgaaagaa taagagaaag gccggctgta tggggaccgc ttttgattgt tgcagcaatt 1384921 atcatcgtcg gtgccgtgct gcaatcactc ggtacggatt atagtgagct tttgaaaagc 1384981 caggatacgc aagggctatc tgctgaacaa atggaaactg tcgcaacaat aaccaaattt 1385041 ggcggaatgg caggcgctat tatcggcggt atcgcagcat tatttattgc ccctcttatt 1385101 tattggctct gtgtaaaagt atcaggcggt gttacgacat ataaaaaaat gctttctctc 1385161 agtctgtttg tctctttgat tagcagtctc ggattattgg ttaatggaat cgttgctttt 1385221 acgactgacg tgaatcctct ttacagcacg acgtcactcg cagggattat cccatctgac 1385281 ggggctctcg ccagtgtgtt aaataccttt gaaattttca gcatctggag ctttgtatta 1385341 ttagcaatcg gacttcacaa aacgggaggc atctcaaaaa aagccgggtg gatttcagca 1385401 atcattctat tcggaatttt agttgtattt tcgctttttt caggtttaat caattctgtg 1385461 gcgggtgcat aagctcatga aaaaagtctg gatcggaatt ggaatcgcag ttatagtcgc 1385521 tctttttgtt ggaatcaata tataccggtc tgccgctccg acaagcggca gcgccggcaa 1385581 ggaggtacag acggggagcg ttgaagaaaa tgaaatctca tcaacggtta tggttcctgg 1385641 cacgctaaaa ttttcaaatg aacagtatgt cttttatgaa gcggataaag ggacattaga 1385701 agacattaaa gtaaaggaag gcgataaagt taaaaagggc acggctttag tcacctatac 1385761 aaatgagcag ctgagcctgg aaaaagaaca gaaccagtta acgtctgaat ccaaccggct 1385821 tcaaattgac caaattcaag aaaagttaaa agccttggac agcaaagaaa gagaactgga 1385881 aaaacaggta ggaaagaaag aagcagaaaa acaaatcgaa tctgaacgga cagagcttca 1385941 aatgcagaaa aaaacagcgg agatcgaatt aaaacaaacc gagcttcagc ggcagtcact 1386001 tgccaaccgg gtgtcagatt tagaagtgaa aagcgaaatt gaaggcaccg ttatttctgt 1386061 caaccaagaa gcggcatcca aaaagtcaga tattcaagag cctgtcatac atatcggcaa 1386121 cccaaaagac cttgtcgtct cagggaaatt gtctgaatac gatacattga aagtcaaaaa 1386181 aggccagaag gtcacactca cttcagatgt aatacagggt aaaacatgga aaggcacggt 1386241 ttccgcagtc gggcttgttc cggatcagca ggagagcgct gcggcacaag gaacagaaca 1386301 ggcggtccaa tacccgcttc aagtgaaaat aaaaggaaat cttccagaag gaaagccagg 1386361 ctttaaattt atcatgaata ttgaaacaga taaacggaaa gcaaatacgc ttccttcaaa 1386421 ggcagtcaaa aaagaagatg accaatatta tgtgtataca gtaaaagacg gaaaagcaaa 1386481 gcgagttgat gtcaaaatcg gcgaagtgac agatgacctg acagaaatta aagaggggct 1386541 tacccaagat gatcaagtca ttttgaatcc atctgatcag gtgactgacg gaatggaagt 1386601 gaaatcctaa atgattcagc tttctaatgt gcgaaaaagc taccagatcg gaaaggaaac 1386661 gtttgatgtt ctccattcta ttgatttgga cattcatcaa ggtgaatatg tctcgattat 1386721 ggggccgtca ggatcaggaa aatcgacgat catgaatatt atcggctgtc ttgatcggcc 1386781 gacttccggt acatatcaat tggacggcga agacatttct tcatataaag ataaagaact 1386841 ggcggcagtc cgtaaccggt ccatcggttt tgtatttcag caatttcagc ttcttccgcg 1386901 gctgaacgca aaaaaaaatg tcgagctgcc gatgatttat tccgggatag gcaaaaagga 1386961 acgtcaagag cgggctgaga gagcattgga aaaggtcggg ttagccgatc gaatgctcca 1387021 catgcccaac gagctgtcgg gcgggcagaa gcagcgggtg gcgattgcga gggcgatcgt 1387081 gaatgagccg aaattgattt tagctgatga accgaccggc gcgctggata cgaaaacaag 1387141 cgaggcgatt atggatcagt ttacagcatt aaatgccgag ggaacgacaa tcgttctggt 1387201 tactcacgag cctgaagtag cagattgcac gaatcggatc gtcatggtgc gtgacggaaa 1387261 cattgttcct gccagctccg gacaaaggag tgtgggagaa tgagcctgtt ggaaaacatc 1387321 agaatggctc taagctctgt ccttgcccat aaaatgcgtt cgatcttaac gatgctcggc 1387381 attatcattg gtgtaggctc tgtcattgtt gtcgttgcgg taggacaggg cggcgagcaa 1387441 atgctgaagc agtcgatcag cggcccggga aatactgtgg agctgtacta tatgcctagc 1387501 gacgaggagc ttgcaagcaa cccgaatgcc gcagctgaat ctacgtttac agaaaacgat 1387561 attaaaggtt taaaaggaat agaaggcatt aaacaagtcg ttgcttcgac ttctgaaagt 1387621 atgaaagcgc gttatcacga agaagaaacc gatgctacgg ttaacggaat aaatgatgga 1387681 tacatgaatg tcaattcttt gaaaatcgaa agcggcagaa cctttaccga caatgacttt 1387741 ctcgcgggga atagagtcgg aatcatctct caaaaaatgg ctaaagagct gtttgataaa 1387801 acctcccctc taggtgaagt tgtctggatt aacggacagc ccgttgaaat tatcggcgtg 1387861 ctgaaaaaag taacaggctt gctttctttc gatttaagtg aaatgtatgt gccatttaat 1387921 atgatgaaat cctcttttgg cacaagtgat ttcagtaacg tatcattgca ggtcgaatca 1387981 gcagacgaca taaaatcggc tggaaaagaa gcggcacagc tggtaaatga caatcatggc 1388041 acagaggatt cgtatcaagt gatgaacatg gaagagattg cggccggaat tggcaaagta 1388101 actgcaatta tgacgacgat tatcggctca attgcaggta tttccctttt ggtcggcgga 1388161 atcggtgtca tgaatattat gctcgtatca gtcacagaac ggacgcggga aatcggaatc 1388221 agaaaatcac ttggtgcgac gaggggacag attctgactc agtttttaat tgaatcagtc 1388281 gtattgacgc tgattggcgg tctggtcggg attggtattg gatacggagg ggccgcgctt 1388341 gtttcagcca ttgcgggctg gccgtcactc atatcctggc aggttgtatg cgggggcgtg 1388401 ctgttcagta tgctcattgg tgttattttc ggcatgcttc ctgcaaataa agccgcaaag 1388461 cttgatccca ttgaagcgct gcgttatgag tagcctcatg caacatgcat gaggtttttt 1388521 tatgtttagt gatttctact atgaatataa aagacttttt tcattaaaat aagaagaaaa 1388581 tgtcgtacaa ttgtccttat ttttgtcgaa tttacagttt acaaacccta tagacatacg 1388641 ttaatatgga gaaacgtgaa agattttgat agttattgaa tgaatttgaa tgattttagt 1388701 tgcctaaacc gaaaatagcg tttacaatga aattgtattc aaaatgaata cgttttcatt 1388761 aggaggtgaa gcatgctaac tcctgaacgg catcaattga ttattgatca aatagaaaag 1388821 catgatgtgg taaagattca agagcttata aatctgacta atgcttctga atcaacaatc 1388881 agaagagatt tatcgaccct tgaagaacgc ggttttttaa agcgcgttca tggtggagcg 1388941 gccaagcttt ccgatatcag acttgaaccc gatatgcttg aaaaatcatc caaaaacctt 1389001 cacgataaac tgaagattgc tgaaaaagct gcttctcttt tagaagaagg ggattgcatt 1389061 taccttgatg caggcacgac gacattgcac atgattgatt ttatggataa aaccaaagat 1389121 attgtcgttg tcacaaacgg ggtaatgcat atcgatgcat taataaggaa agaaatttct 1389181 ttttatctgc ttggaggata cgtaaagcac agaacgggcg cgattattgg aggcgcttca 1389241 ttggttgcca tggaccagta cagatttgac aagagttttc tggggacaaa cggtgtccat 1389301 acagaggctg gatttacaac gccggaccct gatgaggccc ttttaaaaca gaaagcgatc 1389361 aaacaggcaa aacacgctta cgtcttagca gacccttcga agttcggaga aatttcattt 1389421 tcggcattcg ccggaatagg cgacgcaaca atcattacga ctgacgctga agagcttaca 1389481 ttcgataatt accaagaaaa aactgtcgta aaggtagtga aaccatgatt tacactgtaa 1389541 cacttaatcc atctgtcgat tatatagttc acgttgaaga ttttactgta ggaggcctga 1389601 accgttcttc gtatgatacc aagtatccag ggggcaaagg catcaacgta tcgagactgc 1389661 tgaaaagaca ccatgtggcg tctaaagcgc tcggattcgt cggcggattt accggagaat 1389721 atatcaaaac atttttacgg gaagaaaacc tggaaacagc tttttctgaa gtaaaagggg 1389781 atacccgtat caatgtaaag ctgaaaacgg gtgatgaaac tgaaattaac gggcagggac 1389841 cgacaatttc ggatgaagat ttcaaagcct ttttagaaca gttccaatct ttgcaagagg 1389901 gagatatcgt tgttcttgca ggaagcattc catcttcact ccctcacgat acttatgaaa 1389961 aaatcgcaga ggcctgcaaa cagcagaacg cacgagttgt tctggatatc tcaggcgagg 1390021 ctcttttgaa agcaacagaa atgaaaccat ttttgatgaa gccaaatcat catgagcttg 1390081 gagaaatgtt cggcacggcc attacatctg ttgaggaagc cgttccttat gggaaaaagc 1390141 ttgtagaaca aggcgctgaa catgtaatcg tatcaatggc cggagacgga gcgcttctgt 1390201 ttacgaacga agctgtttat tttgctaacg tgccaaaggg gaaattggta aactcagtcg 1390261 gagcagggga ttccgttgtt gcaggtttcc ttgccggaat ttccaaacag ctgccgcttg 1390321 aagaagcatt ccgcttagga gttacttcag gcagtgctac cgcgttctct gaagaacttg 1390381 gaacagaaga atttgtccag cagcttcttc ctgaagttaa ggtcacacgt ctatagagga 1390441 ggaaacacaa gtgaaaataa ctgagctttt aacgaagcat acgataaagc ttaatattga 1390501 gagcaaagaa aaagaaaatg ttattgacga aatggtcact gttcttgata aggctggaaa 1390561 gttaaatgac cgacaagcct ataaagaagc cattttaaat cgcgaaagcc aaagctccac 1390621 gggtatcggt gaaggaatcg ctatccccca tgcgaaaacg gcaagcgtta tcaacccggc 1390681 gatcgcgttc ggacgttcaa aagacggcgt cgattatgaa tcattagacg gccagccggc 1390741 tcacttagtg ttcatgatcg cggcgactga aggcgcaaac aacactcacc ttgaagcatt 1390801 gtcaagactt tcaacgctgt taatgcgtga agaaatccgt aagcagctcc ttgaagctga 1390861 gtctgaagat gccatcatcg acattattaa tcagcacgat aaagatgatg acgaagagga 1390921 agaggaagaa gaagcggcac cagcacctgc cggaaaaggg aaaattttag cggttactgc 1390981 atgcccgaca ggtattgccc atacattcat ggctgcggat gcccttaaag aaaaagcgaa 1391041 agagcttggt gtggaaatta aggtcgaaac aaatgggtca agcggcatta agcacaagct 1391101 cactgcccaa gaaatcgaag atgcacctgc aatcattgtc gcagcggaca agcaggttga 1391161 aatggaacgt tttaaaggca agcgcgtact tcaagttcct gtaacggcgg gtatcagacg 1391221 tccgcaagag cttatcgaaa aagcgatgaa tcaagatgcg ccgatttatc aaggcagcgg 1391281 cggcggttca gcagcttcaa atgatgatga agaagcgaaa ggcaagtctg gaagcggtat 1391341 cggaaacacg ttttataagc acctgatgag cggtgtcagc aacatgcttc cgttcgtagt 1391401 cggcggcggt attctcgttg cgatttcatt cttctgggga attcactctg ctgatccgaa 1391461 tgatcctagc tacaacacgt ttgcagcagc attaaacttt atcggcggcg acaatgcatt 1391521 aaaactcatt gttgcagttc tggccggttt cattgcgatg agtattgcag atcgtcctgg 1391581 ttttgcgcct ggtatggtcg gcggatttat ggcaactcaa gcgaatgctg gattcttagg 1391641 cggcttaatt gccggattcc ttgccggtta tgtcgtgatt ttactgaaaa aagtatttac 1391701 gtttatccct cagtcacttg atggattaaa acctgttttg atttacccgc tgttcggtat 1391761 ttttatcact ggcgtattaa tgcaatttgt cgtcaataca cctgtagcgg catttatgaa 1391821 tttcttaaca aactggcttg aaagccttgg tactggaaac cttgtgttaa tgggtattat 1391881 cttgggcggc atgatggcga tcgatatggg cggtccgctt aataaagcag cctttacgtt 1391941 cggtatcgcc atgatcgatg caggcaacta tgcgcctcat gcagcaatca tggccggcgg 1392001 tatggttcct ccgcttggta tcgcacttgc aacaaccatt ttcagaaaca aattcactca 1392061 gcgtgaccgt gaagctggta ttacatgcta tttcatggga gctgctttcg taacagaggg 1392121 agcgatccca tttgctgcgg ctgatccgct tcgcgtcata ccagctgctg tagtcggtgc 1392181 agctgttgcc ggcggattaa ctgaattctt ccgagtaacg cttccggcgc ctcatggagg 1392241 agtattcgta gctttcatta caaaccatcc gatgctttac cttttaagta tcgtgatcgg 1392301 tgctgtcgtg atggcaatta tcctcggtat cgtcaaaaaa cctgttacag aaaaataaga 1392361 aaaaaagcgt ccttggttcg aaaggacgct ttttcttatc cggccggcag ggagcgcggt 1392421 taagttatgt attttattct tttttatgat aaagtaaaag aagagaaaca actgacatag 1392481 caattgtcta ggaggaaaca ctttgaccga ggaaaaaaat acgaatactg agaaaacggc 1392541 gaagaaaaaa accaatacgt acctggaatg gggtaaagcg attgtcatcg ctgttctgct 1392601 ggctctcctg atccgtcact ttttgtttga accgtattta gttgaaggtt catctatgta 1392661 tcccacatta catgacggag aaaggctgtt tgtgaataaa acagtcaact atatcggcga 1392721 gctgaagcgc ggagatatcg ttattatcaa cggtgaaact tctaaaatcc attatgtaaa 1392781 aagattgatc ggaaagcctg gagaaaccgt tcaaatgaag gatgacacgc tttatataaa 1392841 cggtaaaaaa gtagccgagc cttacttgtc taaaaacaag aaggaagcag aaaaacttgg 1392901 tgtcagtctg acaggagact ttggaccggt taaggttccg aaaggcaaat actttgtcat 1392961 gggagataac cggctgaatt ctatggacag ccgaaacggg ctgggactga tcgcggaaga 1393021 tcgaattgtc ggcacatcga agtttgtctt tttcccgttt aacgaaatgc gtcaaacaaa 1393081 ataaaaacgc cttgctggcc taggacagca ggcgttttta ttttgaaaaa gaagcgacca 1393141 atgcaatgca taaaaccgtg atgaacactg aaccgataat agccagcaca ctgaagaaaa 1393201 ggtgaacctg tttgttctct tttccgcgct tttctaatag ccgtttagaa aaaatgtgcg 1393261 aaaatatgta aataagggct atgcctatat ataagccgat atctttggcg gtaaagcctg 1393321 ttacggcaag gtaaaagccc gtaaaaaaga tcagtaagca atattcagta agtgttaaaa 1393381 gcctcaacgt gttcctccat gagagtgtgt aattttccag gcggatgcat tctctctctt 1393441 taattgtaac acagctggct ggtttgggtg tataagtgtt ttctctctgt tttatcaggg 1393501 aatcatttct cttgccctgc attcatggta tacttttatt gatgatagac atgatggagg 1393561 ataataaatg attgctgtaa ataatgtaag cttgcggttt gcggatcgca agttatttga 1393621 agatgttaat attaaattta ccccaggcaa ctgctatggg ttaattggtg caaacggtgc 1393681 cggtaaatca acgtttctaa aggtgctgtc aggcgaaatc gagcctcaga caggcgacgt 1393741 gcatatgagt cctggcgagc gtcttgccgt cttgaagcag aaccattttg agtacgaaga 1393801 gtatgaagtg ctgaaagtgg tcattatggg ccacaaacgc ctgtatgaag tcatgcagga 1393861 gaaagacgct atttacatga agcctgattt ctcagatgag gatgggattc gtgctgctga 1393921 gctagaaggt gaattcgcgg aactgaacgg ttgggaagcg gaaagtgaag ctgcgatcct 1393981 gttaaaaggc cttggtatct cagaagatct gcacacaaaa aagatggcag acctcggcgg 1394041 ttcggagaag gtaaaagttc tcttggcaca ggcattattc ggcaagccgg atgttctgct 1394101 gctcgatgag ccgacgaacc acctggacct tcaggcaatt cagtggcttg aagagtttct 1394161 gattaacttt gaaaacacag ttattgtcgt atcccatgac cgtcactttt taaataaagt 1394221 atgtacgcac attgccgacc ttgattttaa caaaattcaa atctatgtcg gaaactatga 1394281 tttctggtac gagtcaagcc agctggcgtt aaagctttct caagaagcga acaagaaaaa 1394341 agaagagcag attaaacagc ttcaagagtt tgtcgctaga ttcagcgcca atgcgtctaa 1394401 atctaagcag gctacatcaa gaaagaaact tctcgaaaaa atcacgctgg atgatattaa 1394461 accgtcttcc cgccgctatc cttatgttaa cttcacgccg gaacgggaaa tcggaaatga 1394521 tgttcttcgc gtggaaggct taacaaaaac aatcgatggc gtaaaggtgc ttgacaatgt 1394581 cagctttatt atgaatcgag aagataaaat tgctttcact ggccgaaatg aacttgctgt 1394641 tactacgctg tttaaaatca tttccgggga aatggaagct gacagcggaa cgtttaaatg 1394701 gggtgttacc acatctcaag cgtattttcc aaaagacaac agcgaatatt tcgaaggcag 1394761 tgatctgaac cttgtagact ggcttcgcca atattctccg cacgaccaaa gtgagagctt 1394821 tttacgcggt ttcttaggac gcatgctgtt ctctggagaa gaagtccaca aaaaagcaaa 1394881 tgtactttcc gggggagaaa aggtccgctg tatgctgtcg aaagcgatgc tttctggcgc 1394941 caatatttta attttggatg agccgaccaa ccatttagac ctagagtcca ttacagcgct 1395001 caataacggc ttaatcagct ttaaaggcgc tatgctgttt acttcccatg accatcagtt 1395061 tgtgcagacc attgccaaca gaattataga aattacacct aacggcatcg tcgataagca 1395121 aatgagctat gacgagttcc ttgaaaatgc tgatgtgcag aaaaaattga ctgaactata 1395181 cgccgaataa aaaagcagag atttctctgc tttttttgat acctaaatgt gaaaggagat 1395241 cacaacatga aatttttggt tgtcggagca ggtggagtag gcgggtatat tggcggacgg 1395301 ctttcggaga aaggaaatga tgtgacattt ctcgtgcgcc aaaaacgagc tgagcagctt 1395361 aaaaaaaccg ggcttgtcat ccatagtgaa aaagggaatg tatcatttca gcccgaacta 1395421 atcagtgccg gagaaacagg gcaatttgat gtcgttatca ttgcttctaa agcatactcg 1395481 cttggtcaag tgatagagga tgtcaaacca tttatccatc aagaatctgt cattatccct 1395541 tttttaaatg ggtaccgcca ctatgagcag ctatttgcgg cattttcaaa agaacaggtg 1395601 ctgggcggcc tgtgttttat agaaagtgct ttagacaaca aaggagaaat tcatcatacg 1395661 agcgcatcgc atcgttttgt atttggagaa tggaacggcg agcgtacgga gcggataaga 1395721 gcgcttgaag aggcattttc aggtgtgaag gctgaagtca tcattagcgg gcatatcgag 1395781 aaggacattt ggaaaaagta tctctttatt gcagcgcaag cggggatcac aacgttattt 1395841 caacgaccgc ttggcccaat cctcgccaca gaagccggac gtcacacggc ccaaactctt 1395901 attggggaaa tttgcactgt tttacgaaaa gaaggtgttc cggctgatcc ggctcttgag 1395961 gaagagagct ttcgtacgat gaccagcatg tcttaccata tgaagtcctc catgcttcgg 1396021 gatatggaaa acggccaaac gacagaaggc gaccacctgc atggattttt gattgaaaaa 1396081 gcaaaacgtt tatctctcgc tgcaccagta ttagaaaccg tttatgcgaa tctgcaaatg 1396141 tatgaagcag aaaaataaaa aaaggaggcg gaaaagcctc cttttattta cttaaaaagc 1396201 ccaatttccg tttctgaaga taggctctct tttcccgtct gccgtaattc cgtcaatatt 1396261 catatcctta gaaccgatca taaagtccac gtgtgtaatg ctttcattta ggccttcttt 1396321 gacaagctct tcacgagaca tctgctttcc gccttcaata ttaaaggcat aggcgcttcc 1396381 gatcgccaaa tgatttgacg cgttttcatc aaacagcgtg ttatagaaaa gaatgtttga 1396441 ttgtgatata ggcgaatcgt aaggaacaag tgccacttca cctaaatagt gagaaccttc 1396501 atctgtttcc accagttctt ttaaaatatc ctcacctttt tcagctttaa tgtcgactat 1396561 acggccattt tcaaacgtca gggtgaaatt ttcaataata tttccgccgt agcttaatgg 1396621 ttttgtgctt gataccactc cgtcaacccc gtctttttgc ggcagcgtga acacttcttc 1396681 tgtcggcata ttggccataa actcatggcc actttcattc acgcttcccg cacctgccca 1396741 aacatgcttc ctaggcagct taattgttag atcagttcct tctgcttgat aatgtaaggc 1396801 agcgtaatgt ctctcgttca aatggtcaac tttttcatga agattttggt catgattgat 1396861 ccacgcctga accgggttgt cttcatttac gcgcgtcgct ttaaaaattt cttcccacag 1396921 aaggtggatc gcttcctcct ctgatttgcc aggaaacacc ttgtgagccc agcctgctga 1396981 tgccgcacct acgacagtcc agctgacttt gtctgattga atatattgtc tgtatgtatg 1397041 taatgctttg cctgctgctt tttggaatgc cgcaatccgt ttggaatcta taccttttag 1397101 caagtctggg ttcgacgaca caacagaaat gaaagcagct ccatttttgg caagctcttc 1397161 tctgcctttt gcttcccatt caggatattc ttcaaatgct tcaaacggcg caagttcgta 1397221 ttttaatttg gcgacttcgt catcctgcca attcacggtg acgttttttg cgcccttttc 1397281 atatgcgtgt tttacaatta aacggacaaa atcccgaacg tctgttgaag catttacgac 1397341 tacatactgg cctttttgga cattaacgcc gacttctacc gccagctgtg catatgtatt 1397401 taatttctgt gaaaatgaat ccatgaatca ttcctccaag cttttttctc atcatatcaa 1397461 atatgatcct ataaaggaaa gaaggagccc aaagtgaaaa acccaaaacg acacgtcttg 1397521 ggttttttca atattatgga tgattcagtt ttacagtgcc gcctgcaggc gaatggggca 1397581 tatttgccaa agaaatgctc atgcctccaa gaataattcc gcttaaaatg gctgcgatcg 1397641 ctactcttct tcctaaatct cttagcatct gtttcctcct taacgtttct ccatttccca 1397701 caatatgaag gaagtgagga aaaaagaagc aagaaatttg ccgcgtgtga gaattttgcg 1397761 ggtaaagact atttaattgc cttttgcagc ttatcaatca cttctaaaga acggcctgtg 1397821 ccgattgcta cagattcaag cgggttttgc gccacgtgta caggcacgac aatctcttct 1397881 gtgagccatt ctttaattcc attaaggagc gcgccgccgc ctgttaaaat aacgccgcga 1397941 tcaacaatat ctccgctcaa ttcaggcgga cagtcctcaa gtgtcgctct gatggcttca 1398001 agaatatgca ggagggattc acgcattgca tcttgaattt cgttggattg aagcataatg 1398061 gtttttggaa gacctgtcac gaggtcacgt ccccgaattt ccattgcctc tggtatatgt 1398121 tcaatcagag catggccaat ttccattttt acctgctcag ctgtgcgttc gccgatcagc 1398181 aaattgtatt ttttacggac gaaagaaacg atatcctcat caagctggtc tccgccgatc 1398241 ctgatagaat ggcaggaaac aacgccaccg aaggaaataa tagcgacctc tgtcgtccct 1398301 ccgccgatat ctactaccac attggcaacc ggctcatcaa ccggtaaatc cgctccgatg 1398361 gcggctgcaa ctggctcttc gattaaatga acgtttttcg cgccgcaatt tttcaccgca 1398421 tcactgatgg cgcggcgttc tactgctgtt gagcctgatg gtgtgcaaac gactacgttc 1398481 ggttttctga acgacatgcc gatgcttttt gcggcttttt tcataatgtg ctttagcagg 1398541 tcagttgtca tatcatagtc tgcgatcacg ccatctttca tcggtctgac agcgacaatt 1398601 tttcccggtg ttttaccgat catgtttttc gcgtcagctc cgattgcaag cactgctttt 1398661 gtcgtcgtat ccactgcgac aacagatggt tcatttagga taatcccttt atttttgctg 1398721 taaacaagta tattagctgt tcctaagtca atcccgattt cagttgattg aaacatgttt 1398781 tcacccaatc tctatcctaa tttaatatga ttctacattt aaagtttctc agaaatactg 1398841 cgatttttgg gggtgtgcgt cggtaaagaa atgtttttgt aaaaaatcaa ggaactgtgt 1398901 aacagaagta atacattttt cggttttatg gaaaaaatat cttgtaattc ttatagaaag 1398961 cgggaaactt tttcaaagtt tcattcgtct acgatatatt gaggtacatc cttaaaacat 1399021 tacatgagaa aagaaacatt taaaggaaga agggttttta tgaaatcaat aggtgttgtg 1399081 agaaaagtag atgaattagg ccgcattgtc atgccgattg agttgagacg ggcattggat 1399141 attgccataa aagacagcat tgagtttttt gttgacggag ataaaattat cttgaaaaag 1399201 tacaaacctc atggcgtttg tttaatgact ggagaaatca cttcagaaaa taaagaatac 1399261 ggcaacggta aaattacgct aagccctgag ggtgcacagc tgcttctcga agaaattcaa 1399321 gccgctttaa aagaataaaa ttatgctaaa aaaggcggag tgatatcatc tccgcctttt 1399381 ttgcgtgcca atttttgatt accgccgcct aagataagac atcaagatat ttggtaatga 1399441 atgatttggg atactttaca tattttactc aattatttgt cgaagaatgg tacaataagt 1399501 agagaaacac aagcggcagg tggtcatatg agaaaatatc aagctcgtat catttccatc 1399561 attttggcaa tgatttttat aatgttttgg gattatttat tttattttat aggcaaaaac 1399621 ccgattaatt ggcctgttga tattgtgtat actgcagtca cgctggtaag tgtctggatg 1399681 ttggcttatt atattgatga gaaacagcag ctggttaaga aaatgaagga taacgaatgg 1399741 aagtataaac agctttctga agaaaaaaac cgcatcatgg ataatttgca ggaaatcgta 1399801 tttcaaacga atgcaaaagg tgaaattaca tatttaaacc aagcgtgggc atctataacc 1399861 gggttttcaa tcagtgaatg tatgggaaca atgtataacg attacttcat aaaagaaaag 1399921 cacgtagccg accacattaa cacccaaatc caaaacaaag cgtcttctgg catgtttacg 1399981 gcaaaatacg tgacaaaaaa cggcacgatt ttttggggag aagttcatta taaactttac 1400041 tatgaccggg atgaccaatt tacaggcagc ctgggtacaa tgtcagatat cactgagcgg 1400101 aaagaggctg aagatgagct cattgagatt aatgaacggc tggcgaggga atcccagaaa 1400161 ctatcaatca caagtgaact tgccgcaggt attgctcatg aggtcagaaa ccctttaaca 1400221 tctgtcagcg gtttcctcca gattatgaaa acacaatatc cggacagaaa agactatttt 1400281 gacatcatct tttcagagat taaaagaatc gatttagtgc tcagcgagct gctgctgctt 1400341 gcaaaaccgc aggcaatcac atttaaaaca caccagctta atgagatctt gaaacaagtc 1400401 acgacattgc ttgataccaa tgcaattctg tccaatatcg tcatagagaa aaatttcaaa 1400461 gagacagatg gctgtatgat taatggagac gaaaatcagc tgaagcaggt ctttatcaac 1400521 atcattaaaa acggaattga ggcaatgcca aagggcggtg tcgtaaccat ttcaactgct 1400581 aaaaccgcct ctcatgcagt gataagcgta aaggatgaag gaaacggcat gccgcaggaa 1400641 aagctgaagc agattggcaa acctttttat tcaacaaaag aaaagggcac tggactggga 1400701 cttcccattt gtttgagaat cctgaaggaa catgacgggg aattgaaaat cgaaagtgaa 1400761 gctggaaaag gcagcgtctt tcaagtggtt ttgcctttaa aatcagacag ctgagaggag 1400821 aaaaataaag tgaactcgct tctgtttgta tacgggacat taagaaagca tgaaaaaaac 1400881 catcatttgc tggcacaatc ggcatgtatc aatgagcagg cgagaacaaa gggaagtttg 1400941 tttgctgcaa aagaggggcc cacagttgtt ttcaatgatg aagatgaagg ctatatatat 1401001 ggcgaagtat atgaagcaga tgaattgtgt atacataagc tcgatcaatt ttttcaagga 1401061 tatcataaac aaacggtgtt tgtagaaacg gatgtcggga ttaaaattgc gcttatttat 1401121 tttatgaaca aagacgggtg tgccggtttt acgaaaataa gcagcggcga ctggaaagaa 1401181 catcagatga tcagcaaatc gaaaaatccc atttattatt ttgcctatgg atcatgcatg 1401241 gataatgccc gctttcaaaa agcgggagtc gatcactatt ttcaagatcc agtaggaaga 1401301 gctgttttaa aaggatacac aacccgcttc acgctaaaaa gggaagacgg ttcaagagcg 1401361 gacatgttgg aagacggagg aacaacagaa ggcgttttat accgtatccc ttattctgct 1401421 ctctcctatc tatataaaag ggagggcgtc gaatctctta cgtatcggcc ggcatttgta 1401481 gacgttgaag ctggcggaag gcactacaaa gactgtttaa cctttctcgt cctccaaaaa 1401541 gaagcggaaa ttgccccgcc tcagcactat cagattgaaa tcgaacgcgg agcggagctg 1401601 tatttgtcgc ctgagtttac tgaaaagctc aagcggcata tgaattcgct gccaaaagga 1401661 taacactgta acaaaagaat atgataaaat ttgatcaata tcatgtcata taaaggagca 1401721 ccacgatgaa aaaagaattt gcggtaattg ggctgggccg ttttggtggc agtatttgca 1401781 aagcattaag cgaagaaggc gtcgaggtta tggcaatgga tatcgatgaa gataaagtca 1401841 acgagtatgc caagattgca tctcacgcag ttatcggtga ttcgacagac gaatctgtcc 1401901 tgaaaaattt aggcctgcga aattttgacc acgttattgt agcaatcggg gaaaatattc 1401961 aagcgagtat tttaacgaca ctcattctga aagaacttgg cgtccatacg attacagtta 1402021 aagcgcagaa cgattatcac gaaaaagtgc tgtctaaaat tggtgcggat cacatcgtcc 1402081 acccggaacg cgatatggca aaacgaattg cgcataatat cgtgtccaac aatgtacttg 1402141 actatttgga gctgtctgaa gagcatagtc ttgttgaaat cgtagctaac agccgcctgg 1402201 ctggaaatac gcttctcgat ttagatattc gcgcaaaata cggtattaac atcgtagcca 1402261 taaaaagggg caaggaagtc atcgtatcac cgcttgcaac cgaagtcatc caccaagaag 1402321 atatactcat tgttattgga tcagttacag acatctcccg tttcgaaaaa agagttcttc 1402381 atacaaaata gcagccaaat aagccgtcct caaagggcgg tttttcatat tatcagaata 1402441 taacaacttt aatgaactga gcgtcaattt cttaaaattt cattgactaa gcacaggcgt 1402501 tccgatagca tattgtacca tataataaaa aaaggagggg cctatttgaa taaagaagcg 1402561 ctagtcaata ggctgaatgc ttcagccaaa agacaaaaag ctgatatcgt cattaaaaac 1402621 ggaaaaatca tggacgtata taatcaagaa tggatatatg aagatattgc gattacagat 1402681 ggagttattg taggcctcgg tgagtatgaa ggcgaaaata tcattgatgc agagggacaa 1402741 atgattgttc cgggttttat tgatggacat gtacatattg agtcgtcaat ggttacaccg 1402801 attgagttcg ctaaagcagt gttgcctcat ggcgtgacga cggttgttac agatccgcat 1402861 gagatcgcga atgtgtctgg tgaaaaaggg attgagttta tgcttgaaca agctcggcat 1402921 acaccgctga atatccattt tatgcttcct tccagtgtgc ctgccgcaag ttttgagcga 1402981 tcaggcgcaa ttctcaaagc tgccgatctc aagccttttt atgaagaaga agaagtatta 1403041 gggctggctg aagttatgga ttatgtgtcg gttcagcagg ctgaaaaaga catggttcag 1403101 aaactgcttg atgcccgtgt ggcaggaaaa aggatagacg gtcatttagc tggtttatca 1403161 acagacctca ttaacattta cagaaccgca tttgtcttaa acgaccatga agtaacatcg 1403221 aaggaagaag cccttgatcg tatcagaagg ggcatgtatg tcatgatgcg tgaaggatca 1403281 gtcgccaaaa acacgctcaa tgtgctgccg gcggtgaatg aaaagaacgc acgccggttc 1403341 tttttctgta cggatgataa gcatgtggat gatttattgt cagagggaag tgtaaaccat 1403401 caggtgaaaa tggcgattca agccggactt aatccgtttt tagcctatca gctaggaagc 1403461 ctcaatgcag ccgaatgcta cggattagat acaaagggag cgattgcccc gggttttgac 1403521 gctgatttgc tttttgtatc tgatctggaa aatgtcactg tcacaatgac gatggtaaaa 1403581 gggcagactg ttgctgaaga cagcaaagcg gtctatcagg atcatgcttc aactgcagca 1403641 ccagatcagg cactgcttga ttctgttaag cttgctgctc ctcttaacaa acaggatttt 1403701 catatgccaa tcgattcaga gcagcagatc aatgtcattc aaatcatacc aaatcagctt 1403761 gaaacacgat tagtacaagt tccggctcct gttgcccgcg aatttgagcc tgacactgag 1403821 cttgatttgt taaagattgc agttgtcgag cggcataaag gattaaaaga aaccggactt 1403881 ggtgttgtga aaggttttgg attcaagagc ggagcgattg ccacaaccat ttcacacgac 1403941 tcccataata ttattgccgt cggaacgaat gatgaggata tcgcggcggc agttaataag 1404001 ctgcaggaaa ttggcggagg attaacaatt ataaaaaatg gggaagagct ccattcagta 1404061 ccgctgccga ttgcagggtt attatccgac caatctgcag agcaagtgaa tcaaagcttg 1404121 ctgacgcttc atgataaatt gtcgttaatc ggtttcacag gcggatttaa tccatttttg 1404181 acattgtcgt ttttagcgtt gcctgtcatt cctgatatta aaatgacgac tacgggatta 1404241 ttcgatgtaa aatcatttca acacatatca ctgcaataaa aagaggcact cccttaggga 1404301 gtgcctcttt ttttaaacct ccataatgat cggcaggatc attggacggc gctttgtttt 1404361 ttcgtacaag aaaggtgcaa gcgtgtctgt aatttcgttt ttgatttcag accattgagt 1404421 cgtttttcgt tccattactt tttgtaagtg atttgaaatg agctcttgag cgtcgttgat 1404481 caagtcacca gattctctca tgtacacaaa tcctctggaa atcaaatcag gacccgctga 1404541 aatcttgaag tcgtccatgt caatgctgac aacaacgatg acaagtcctt cttcagagag 1404601 aattctgcga tcacgaagta cgatattgcc aatatcaccg ataccgcttc cgtcaatgta 1404661 cactgaaccg gacgggattt ttcctgcaac tgaagcctca tcgcctttaa gtgctaatac 1404721 ttcaccatta tccatgataa agcagttttc ctctgggatg ccacaatctg ttgcaagttt 1404781 gacatgcatc ttttgcattc tgtactcacc gtgaatcggc atgaagaatt taggcttgat 1404841 taaacgaagc atcagcttct gttcttcctg tccgccgtga ccggatgtat ggatatcgtt 1404901 aagagggccg tgaataacct cagcacccgc acgatacagc tggttgattg ttcgactcac 1404961 gctgattgtg ttgcctggga taggggatga agaaaatacg actgtatccc caggattgat 1405021 tgaaatttgg cggtgtgtgc cgtttgcaat tcttgataac gccgccattg gttccccttg 1405081 gcttcctgta cataaaattg ttactttatt agcaggcata cgattgattt cgttatgctc 1405141 aataaacgta tttttaggac agttaatata accgagtgtc tgtccaattt cgatagccga 1405201 ttccatactg cgtccaaata cggcaacttt tcttccattt tgtacagcag cttcaattac 1405261 ctgctgcaag cggtgaatat tcgacgcaaa tgtggcgaag ataattcggc cgtccacctt 1405321 gcggaaaatg tcatgaatgc tttctcctac acggcgctca gacatggtaa actccggatt 1405381 ttcactgttt gtgctgtctg aaagaaggca caaaacgcct tctttaccga tttcggccat 1405441 tttcgttaag tttgccggct cgccgactgg agtaaagtcg aatttgaaat ccccagtatg 1405501 tacgatgttt ccgggcggcg tttttacaac aatgccgtag gaatccggaa tactgtgtgt 1405561 tgttctgaag aatgacacag ccgttttgcg gaactttaca atatcatcct cgccgataat 1405621 gttcagtttc gtctgtctca ataatccatg ctcttcaagt ttattccgaa gtaagccgat 1405681 cgcgagtttt ccgccgtata caggaatatt cacttgtctg agcaggtatg gaataccgcc 1405741 gatgtggtct tcgtgcccgt gggtgataaa aagcccttta attttatctt cgtttttgac 1405801 taaatacgta taatcaggga tgacgtagtc aattccgagc agttcgtcct cgggaaactt 1405861 gatccccgca tcaatcagta caatttcatc ctggaattgc accgcgtacg tatttttacc 1405921 gatttcgccc aaacctccga gggcgaaaac agcagtctga tcatttttta caaatttcat 1405981 accgctcata actccaatac tttaaaattt tcgctctgtt gttcatattc taagaatgca 1406041 ccatcaacag gtgtaataaa ctcaatatta aatttctttt ctttcagctt tgttctgacg 1406101 tcacgctcag atacgccttc aatataaagt gaatctgtct tttcccgaac aggtacttcg 1406161 tcagccttct cttgataaaa taccttataa atcattccaa atctctcctt aaatgccgta 1406221 tgttagactc gctcattcta ttatattcga aaacggaata taaggaaagc cttgagcaaa 1406281 ataaggatct ctcaaaaagt gaaagatccc ttgtcaggca attgctttct tacggagcat 1406341 tccgttccat tgtcttctga gtttctttct taatttacgc agcattagcc agtccctcct 1406401 ttaatgaaaa atttgtccca gagttctttt atacaaatag tatacggaga ttgaggaaga 1406461 cttttcgtgg ttattaatgg aatttaatat gatttttgaa cgaaattgtt tgctgaatga 1406521 caatcttttt gtatgatgag ggtgggaatt gcagaccaag acgataaagg ggaagttgcg 1406581 atggattcta aattaatctt ttttgatatt gacggcacaa tatatgatca tgataagaat 1406641 ataccggaaa gtacgagaaa aaccgtggcg gagcttcagc gccaagggca tcatgtgttt 1406701 attgccagcg gccggtctcc atttttggtt aagccgattt tggaggagct gggcatccac 1406761 tcatttattt cctacaatgg acagtttgtt gtctttgaaa atcaagtgat ttataaaaat 1406821 ccgctgcctg aaaatgcaat caggcgatta ttaaagcagg cggatgaagg caagcatcct 1406881 gttgtgttta tggctgagga cacgatgaaa gcgactgttg cggatcaccc ccatgttctc 1406941 gagggaatcg gcagccttaa aacagattat ccagagaccg atgacctttt ttatgaagga 1407001 aaagaaattt ttcagcttct tttattttgt caggatgaag aagaaaaagc ttatgccgct 1407061 tttcctgagt ttgatctagt tcgctggcat gagctatcga ctgatgttct gccgcacgga 1407121 ggttcgaagg cagaaggaat caaaaaagtg attgagcgtc ttccgtttga tatcggcgat 1407181 acatatgctt tcggcgacgg attaaatgat ttgcaaatga ttgaatacgt tgggacaggc 1407241 gttgctatgg gaaatgctgt tcccgaactg aaagaaatcg cggactttgt aacaaaaccg 1407301 gtggacgagg atggaattgc atacgctgtc aaagaattgg gccttttaaa ataaagaaac 1407361 ggctggcatt gtgccagccg ttttctcttt tagcgctcaa ttgcgattgc attttcaggt 1407421 tctttgaaag gattttcctt atcaatatga tcatagaaca taacgccgtt caaatgatcg 1407481 atctcatgct gaaacacaat agccggaaat ccttttaaac gaatatcaat attttcgcct 1407541 tctagtgttg ttccttttac tctgatgcga gcatagcggg gaacataacc gggaatcgct 1407601 tcatccacag agaggcagcc ctcgccgctt gttaagtagc ttttttcaac tgaatggctg 1407661 acgatcttag gattaaacag agcatagctg tataatttac cggaagcatc ttccgcatga 1407721 acggcgatca ttcgtttttt gatattaatt tgaggagctg cgagtcctac gccagggcgc 1407781 agcttgtatt tttcggctaa ttctggattt tggctgtttt taacaaattc gatcatgtcg 1407841 gccagctgct gtttttctgc atcagttgga ggcagctcaa caggttcggc agtctctctg 1407901 agggctggat ggccgtcacg tacgatgttt tccatagtaa tcaagaaact tcactcctaa 1407961 agcttaatat gtaaattata tcggatttct tcacaaaggt gcaacgaaac gaatgaccag 1408021 ccgtatatgg ctggtcaatt tcatgctgtg tggttagcaa cagcctccac ctaaataagc 1408081 agctccgaca atgattaaca gaatgaataa aacaacgatt agcgcaaagg tgcggccgta 1408141 gccatatccg cagccaccat atccgtaacc accataactg cagcagcctc cgccgtaacc 1408201 atatccatac atattacata acctcctctt ttaattacgc cagagccttt ataagtaggc 1408261 atagcgtcta atataaccta tgtaaaaaca aaaaagttgt atggtcatct gtcctgattt 1408321 ttcacttttt tgatttaatt tcagtattgc atttatacag cacggctatt gccaaatgtc 1408381 cccatggatt ctatagtaga aattgtcaag attgggggat ttaacgtgaa agacgctata 1408441 aaacggcggc ctggaatcaa gatcggagct ttttgtgcca tggcactgat attaacagga 1408501 tgcatgggac aggacccggt tgattcactt catcattcat tagaaaaagc cgcggaatcg 1408561 gaaaagccgt ttcaagaaga acaaaacaca ctcaaagaat tagaggccaa agaaaatcag 1408621 ctttacgata gtgttatgaa gctcaatatg gatgattata aaaaaattgt tgctttatct 1408681 aataaggcgc ttgaaaatgt cagcaagcgc gaagaacacc taaagcttga aaatgacagc 1408741 atgaaaaaat cggaaacaga atttgaggaa gcaaaaacgt cagcggaaca tattaaggaa 1408801 aaagacataa aagaaaaggc cgatgccgca gcaaaccata tggagaaaag atatacatca 1408861 tatggcacta tgtataaaga gtataaaaaa gcgcttgagc ttaataaaaa actgtatatg 1408921 cagctgaaag acaaagattt gacaagagat gatctggatc agcagatcga taaagtcaat 1408981 gcttcttatg aaaagatcct taaatatagc ggagaattta atgaacaaac cgaaaaatat 1409041 aataaagccc gggaagattt atatgatgct gcaggctatc gtgtgaaaaa gagctgactc 1409101 gatcagctct ttttttgaat gaaatgcgat tcggatttcg ttcaaaattt tcatttctat 1409161 tgtagtacag catagtaagg tatactagta cagttttggg tgcggttggc atctgttttt 1409221 ttgatgaaaa tgtaaagcga atacatttat tgaaaatcag cgatgaaaac gattgacggt 1409281 tcttctttat ttggtgtaaa ctaatccatg ttaagcggtg ttgtattagt tttttacaac 1409341 ttcgaaataa tacagttcaa agcagagtgt aactatccta cataaaaggt tttggcaaac 1409401 tggggatcgg ctaaaatata atacgactta ctgctgatac tttagggtac cctaagtttg 1409461 tatgtataaa aggaatgcac gtctaatgac tgtttaaaag aaaggaagag gtgacttagt 1409521 atggctgcaa aaacgaaaaa agctatcgtt gacagtaaga agcaatttga tgccattaaa 1409581 aagcagttcg aaacgttcca aattttaaat gaaaagggag aagtcgtgaa tgaagcggcg 1409641 atgcctgatt taactgatga tcaattaaaa gagctaatgc gccgcatggt atttacgcgt 1409701 gtgcttgacc aacgctctat ctcattaaac cgtcaaggac gtctcggatt ttacgctcct 1409761 actgcgggtc aagaagcttc tcagattgca acgcatttcg cgcttgaaaa agaagacttt 1409821 gttcttcctg gataccgtga tgtgcctcag ttaatttggc acggccttcc attatatcaa 1409881 gcgtttcttt tctctcgcgg acatttcaga ggaaaccaaa tgcctgatga tgtgaatgcc 1409941 ctttctccac aaatcattat cggtgctcaa tacattcaaa ctgccggtgt tgcgctaggt 1410001 cttaaaaaac gcggtaagaa agctgtcgca atcacttaca ctggtgacgg cggagcttct 1410061 caaggggact tctacgaagg aattaacttt gccggagctt ataaagcacc tgcaatcttc 1410121 gtggtgcaaa acaaccgtta cgcgatttca actcctgttg aaaaacaatc tgcagctgaa 1410181 acaattgcac aaaaagctgt agctgccggt attgtcggcg tacaagtaga cggaatggat 1410241 ccgcttgctg tatacgcagc aactgctgaa gcacgcgagc gcgcaatcaa cggcgaaggt 1410301 ccaacactaa ttgaaacact tacattccgt tatggcccgc acacaatggc tggtgacgat 1410361 cctactaaat atcgtacaaa agaaatcgaa aatgagtggg aacaaaaaga tccgcttgta 1410421 cgtttccgtg cgttccttga aaacaaaggc ttatggtctg aagaagaaga agcaaaagtg 1410481 attgaggatg cgaaagaaga aattaagcaa gcgatcaaaa aagctgatgc tgaaccgaag 1410541 caaaaagtaa ctgatttaat gaaaatcatg tacgaaaaaa tgcctcacaa ccttgaggag 1410601 caatttgaaa tttatacaca gaaggagtcg aagtaagcca tggcgcaaat gacaatgatt 1410661 caagcaatca cggatgcgtt acgcacagaa ctgaaaaatg acgaaaatgt cttagttttc 1410721 ggagaagacg ttggtgtaaa cggcggcgta ttccgtgcga cagaaggatt gcaaaaagaa 1410781 ttcggtgaag accgtgtgtt tgacacgcca cttgctgaat ctggtatcgg cggtcttgcc 1410841 cttggtttag gcttaaacgg cttccgtccg gtaatggaaa tccaattctt cggatttgtt 1410901 tatgaagtaa tggattcagt ttctggccaa atggctcgta tgcgctaccg ttctggcgga 1410961 cgctggactt cacctgtaac aattcgttct ccattcggcg gcggtgttca tactcctgaa 1411021 cttcacgctg acagcttgga aggtcttgtt gcacaacagc ctggtatcaa agttgttatt 1411081 ccatcaactc cttacgatgc caaaggactt ttaatttctg cgatcagaga caatgatcct 1411141 gttgtcttct tagagcatat gaagctttac cgttctttcc gtcaggaagt tcctgaagaa 1411201 gaatacacaa ttgagcttgg aaaagctgac gtgaaacgtg aaggtactga tctttcaatc 1411261 atcacttacg gcgcaatggt tcatgaatca ttaaaagctg ctgatgagct tgaaaaagac 1411321 ggcatttctg ctgaagttgt cgaccttcgt acagtaagcc cacttgatat cgatacaatt 1411381 atcgcctctg tagaaaaaac aggacgcgcg attgtcgttc aagaggcaca aaaacaagcc 1411441 ggtattgctg caaacgtagt agcagaaatt aatgaccgtg cgatcctgag cttggaagca 1411501 cctgtacttc gcgttgcagc gccagataca gtatttcctt tctctcaagc ggagagcgta 1411561 tggcttccaa accataaaga cgttcttgaa acagcaagaa aagtgcttga attttaatca 1411621 aactgcataa tcgagaggga agatgaacgt tttccctcta ttatatatct gttttcaatg 1411681 cttacgatgt aaactttaaa attgcttaat caaactagga ggtcgagaac tgtggcattt 1411741 gaatttaaac ttccagatat cggggaaggt atccacgaag gcgaaatcgt aaaatggttt 1411801 gtcaagccta acgacgaggt agacgaagat gatgtactgg ctgaagtcca aaatgataaa 1411861 gcagtagtag aaattccttc acctgttaaa ggaaaagtat tagaattaaa agttgaagag 1411921 ggaacggttg caactgttgg acaaacgatt attacgtttg atgcacctgg ttacgaagat 1411981 cttcaattta aaggcagcga cgagtctgac gatgcgaaaa ctgaagcaca agttcagtca 1412041 actgcagaag ctggacaaga cgttgcgaaa gaagagcaag ctcaagagcc tgcaaaagct 1412101 actggcgcag gacagcagga tcaagctgaa gttgacccga acaaacgcgt gatcgctatg 1412161 ccttccgtac gtaaatatgc acgtgaaaaa ggtgtagaca tccgtaaggt tactggttca 1412221 ggcaacaacg gacgtgttgt aaaagaagat atcgacagct ttgtaaacgg aggagcgcaa 1412281 gaagctgcac cgcaagaaac agctgcacca caagaaacag ctgctaaacc ggctgctgca 1412341 ccagctccag agggcgaatt cccagaaaca cgcgaaaaaa tgagcggtat ccgtaaagca 1412401 attgcaaaag cgatggttaa ctctaaacac actgctcctc acgtaacgtt aatggacgaa 1412461 gtggacgtaa caaaccttgt tgcacatcgt aaacagttca aacaggttgc tgctgatcaa 1412521 ggaatcaagc tgacttactt gccttacgtt gtaaaagctc ttacatctgc actgaaaaaa 1412581 ttccctgttt taaacacgtc aattgacgat aaaacagatg aagtcatcca aaaacattac 1412641 ttcaacatcg gtatcgctgc tgacactgaa aaaggcttgc ttgtaccggt tgtgaaaaat 1412701 gcagatcgta aatctgtctt tgaaatttct gatgaaatca atggccttgc aacaaaagct 1412761 cgtgaaggca agcttgctcc agctgaaatg aaaggcgcat cttgcacaat tacaaacatc 1412821 ggttctgccg gcggacaatg gttcactccg gttatcaacc atccagaagt tgcgattctt 1412881 ggtatcggac gcattgcaga aaaagcgatt gttcgtgatg gcgaaatcgt agcagctcca 1412941 gtcttagctc tttctctcag cttcgaccac cgtatgatcg acggagcaac tgcgcaaaat 1413001 gcattaaatc acatcaagcg tttactgaac gatccacaat taattttaat ggaggcgtaa 1413061 tgttatggta gtaggagatt tccctattga aacagatact cttgtaattg gtgcgggacc 1413121 tggcggctat gtagctgcca tccgcgctgc acagcttgga caaaaagtaa cagtcgttga 1413181 aaaagcaact cttggaggcg tttgtctgaa cgttggatgt atcccttcaa aagcgctgat 1413241 caatgcaggt caccgttatg agaatgcaaa acattctgat gacatgggaa tcactgctga 1413301 gaatgtaaca gttgatttca caaaagttca agaatggaaa gcttctgttg tcaacaagct 1413361 tactggcggt gtagcaggtc ttcttaaagg caacaaagta gatgttgtaa aaggtgaagc 1413421 ttactttgta gacagcaatt cagttcgtgt tatggatgag aactctgctc aaacatacac 1413481 gtttaaaaac gcaatcattg ctactggttc tcgtcctatc gaattgccaa acttcaaata 1413541 tagtgagcgt gtcctgaatt caactggcgc tttggctctt aaagaaattc ctaaaaagct 1413601 cgttgttatc ggcggcggat acatcggaac tgaacttgga actgcgtatg ctaacttcgg 1413661 tactgaactt gttattcttg aaggcggaga tgaaattctt cctggcttcg aaaaacaaat 1413721 gagttctctc gttacacgca gactgaagaa aaaaggcaac gttgaaatcc atacaaacgc 1413781 gatggctaaa ggcgttgaag aaagaccaga cggcgtaaca gttactttcg aagtaaaagg 1413841 cgaagaaaaa actgttgatg ctgattacgt attgattaca gtaggacgcc gtccaaacac 1413901 tgatgagctt ggtcttgagc aagtcggtat cgaaatgacg gaccgcggta tcgtgaaaac 1413961 tgacaaacag tgccgcacaa acgtacctaa catttatgca atcggtgata tcatcgaagg 1414021 accgccgctt gctcataaag catcttacga aggtaaaatc gctgcagaag ctatcgctgg 1414081 agagcctgca gaaatcgatt accttggtat tcctgcggtt gttttctctg agcctgaact 1414141 tgcatcagtt ggttacactg aagcacaggc gaaagaagaa ggtcttgaca ttgttgctgc 1414201 taaattccca tttgcagcaa acggccgcgc gctttctctt aacgaaacag acggcttcat 1414261 gaagctgatc actcgtaaag aggacggtct tgtgatcggt gcgcaaatcg ccggagcaag 1414321 tgcttctgat atgatttctg aattaagctt agcgattgaa ggcggcatga ctgctgaaga 1414381 tatcgcaatg acaattcacg ctcacccaac attgggcgaa atcacaatgg aagctgctga 1414441 agtggcaatc ggaagtccga ttcacatcgt aaaataattt tcatatcaaa aacagccccg 1414501 ctttgagcga gggctgtttt tttattttga cagcacatgc tgtaatggtt taatgatgtc 1414561 ttctttcttt ttcacacatc cctcgatttt caccacgaca tggcgctgat caacaaccat 1414621 aagggtaggg acagtttcaa tctcatcttc ccagccttct tttttatcat agaccttcat 1414681 tttatctatt tgctcgggat aatctttttc taaatcaagc agtgcatcgt aataaggcgc 1414741 ttcctggtct atttggttct catcagaaaa aaacaggatt tgtgtatgat gaatgttgtc 1414801 aatccggctt tttttcatcg gattgatggt ggaaagcgta cagcccgata aagcaaatac 1414861 tattatcagc atggggaata ccgcgcgata tcgcatctat cttctcctct gtataaacag 1414921 tagttaacta gctttagttt atcacgagag acggcttaat ctgcttcttg ttacctaatt 1414981 gttatataat tgaaaccgtt tttaaagtga gattacatat tatatcaatc gtttaaaata 1415041 gcaacctggg gtatattgaa ttttttgctg cattcttgga tgaaagttca agaaaacgtg 1415101 caattacatt atgtgctgtg gcatatatat cgagtaaagc ttctgtatga agaagatatt 1415161 gtatgatgga aaatggaaaa acaaggtgaa tatgatgata tgaaataaaa tgtgttatac 1415221 agtttgttgt tgacatttta aatgtgacat attaatataa taacaacaaa agaaattaag 1415281 cgttttcaaa tttcaaagaa atggggaata agagatgggt acgattgttt gccaagattg 1415341 caacgaagcc attcattact ttgaagatga gaaagtgaca acattatatg gaacttgctg 1415401 cggacaatgt caatgtcctg ttgatgaaga gtaaaaaaaa gcatgcggct taaagccgca 1415461 tgctttttat tttttattga attgcttttt gttctttgat gacccggatc atatgtaaag 1415521 tcgagtcctc aggtccttga acagggaggc ctgcgtcaag gtttttaaaa atgtagctga 1415581 tgttttcttc tgtaataatt tctcctggga tgaagattgg aataccaggc ggatatacca 1415641 tgacaaattc agcaataatc cgtccggatg cttcttttaa tgggatgact tccgtatttg 1415701 catagaaagc atcacgcgga gtcattgcca ataaaggtat ttctggaagc agaacctcag 1415761 tttgctgatg tgttacatct tgttctgaca tttgctgtgc gatctcagtt aaagcctcta 1415821 caagccggtc tgcatcattt tggctgtcac caggagtgaa aatacacaaa atattgtaca 1415881 gatcagaaag ctccacctca atattaaagg attcacgaag ccatttttcc acgtcatgtc 1415941 ctgtcaggcc aagacttttc acagagataa tcaattttgt cggatcatag ctgtaagctg 1416001 ctttcgaccc aagaatctca gaaccgacac aataaatgcc ttcaatctga ttgaggcgat 1416061 ctctcgtctg attggcaagc ttgagtgttt cctcagcaag ctggcggcct tctgttgcaa 1416121 ggcgttttct ggcaacatcc aaagaagcga gaagcaagta agaagttgac gtagttgtca 1416181 gcatgctcag gatggattgc actctgtctt tagatacaag gccttctctc atgtttaaaa 1416241 tagagctttg tgtcagtgat ccgcccagct tgtgtacact tgtcgctgct atgtccgctc 1416301 ctgcctgcat agccgatagc ggcaattcgt cgtgaaaatg aatgtgaacg ccgtgtgctt 1416361 catccacaag cactggcaca tcaaacgaat gagcgagttc tacgatgctt tttaagtcgg 1416421 ctgcaacacc gaaatatgtc gggttgatga cgagaagccc ttttgcatcc ggatgctcgg 1416481 taagcgcccg tttagcagat tcaagtgtaa ttccgtggga gatgcccaat tcattgtcaa 1416541 tttcaggatg aataaaaatt ggaaccgctc cggaaaatac aatagctgtc ataattgatt 1416601 tatgaacatt tcttggaata ataattttat caccaggtcc gcaaacagcc attaccattg 1416661 tcataatggc gccgcttgtt ccttgaacag aaaaaaatgt atgatccgct ccaaatgctt 1416721 cagcagccag atcttgtgct tgtttaataa tgccttttgg cgcgtgcaga tcgtctaatg 1416781 gttcaatatt aatcaaatct atgcttaacg cgttttcacc gataaattgt ctgaattctg 1416841 ggtccattcc tgcccctttt ttatggccgg gaatgtggaa ttgaacaggc tgtctgcttg 1416901 catgcttttt cagtcctgtg tataagggtg tttcatgttg cgacaattgt tttcccacct 1416961 ttgtaatcat acctatgcat aatagtgtgt attaaaatca gtttctcaac cgttttttag 1417021 acgtaaaaca aatgaattat attatgaact tgaaagaatg taaagaacaa tttatgatca 1417081 aatgaagatg ctttctctta agggaagtaa atctacaagg agtgaagaaa atggagtatc 1417141 aatatccgat gaatgaagat tggacaaccg aagaagcagt ggatgtgatt gcatttttcc 1417201 agcaggttga gcttgcatat gaaaaagggg cggatcgtga agaactgctt aaagcttacc 1417261 gccgtttcaa ggaaattgta ccggggaagg ccgaagaaaa aaagctatgc ggcgagtttg 1417321 aggaacaaag tacatattct ccttatcgca cggtcaaaca ggcgagagaa tctgatcacg 1417381 cgaagattaa gatgtaagaa aaagagccgg gggatatccc ggctcttttt tatgcttgtg 1417441 ttactttttg ggtgagacgg tacagaaaag caagctgttt aaaggcatcg tcgatacgct 1417501 gaaggaattc ctggttattc atattcagca cttcttcttt ttggagctgg atgccgcata 1417561 acagctcggc tttctttaca gtctgcaaac gctcaaacag tgtcttcagc tgttccttgt 1417621 ccatttcaga ctgtttatgt actcccggtt ttgtgtgatc tgcagaccaa acgaagctgt 1417681 cagggatatt tttcgtaatg gtttcttggt tcacttcaag caatttgccg tattcttctt 1417741 tgatagggga ttcataaata atcgcgaacc atacaaagac gtggctttcc cataaaccaa 1417801 tttggaaatg cggcagtttt ttatagcctc ttttgctgtt tgcgaacgcc acccagctgt 1417861 cagccggggg attgacggat cttcttgcgt gctttgccac atgcggaaac atttcatctc 1417921 cggttaaagc tgataaagtt ggggcaaaat gttcgcctag agctgtaagc ttcggacgga 1417981 ccgtctcttt taatacttcc atgcgcgcgt ctaagccttc tattgtaaat gtgttaaagt 1418041 cttcttcagt gaaacgcatt tgtgtcatga ttttcctcct tcatgctaag tatacatatt 1418101 ttatcacagt tcatacgagc ttcaaaaaga ttgagcgcgt ttgaagtaag gagaaatgtg 1418161 gtaataaacg agtaggtaaa cacacaattt tcagaatcat gttgcgcgta aatagaacaa 1418221 tcatacgata taagaagtaa tcattgttga atggcaaaat gggatgcttt tttacaaaca 1418281 aatgatctct ggaaggggcg aaagacaatg aggcaagttg taaaagaggg atttaaggaa 1418341 gagaaaaaca atcgtgttgc tgtctggaga ctagaggttg attatgaatt ggcaacccta 1418401 tatgaagcaa tgcagaaaga aaatgaagag cagattgaac aaagcaaaaa caaacttgag 1418461 cgacttagaa aagaatggat tcgtcttaac gggtaaaaaa gcgatagtga aaacgaaccg 1418521 catgaatggt tcgtttttac gtgagaaggg atatttttca ttttccttgc tttttcattg 1418581 ccgttatcag tatcctataa aataaaaggt ctacatagaa gagaggtacg aacgaatgac 1418641 aaattggacg gaaatcgatg agattgcaaa gaaatggata agagaagcag gcgcgagaat 1418701 tacacaatcc atgcatgaaa gcctgacaat tgaaacgaaa tcaaatccga atgatttagt 1418761 caccaatatt gacaaagaaa ccgaaaagtt tttcattgat cgaattcaag aaacatttcc 1418821 gggacatcgg atactcggtg aagaggggca aggagacaaa atccactcac ttgagggagt 1418881 cgtatggatt attgatccga ttgatgggac gatgaatttt gtgcaccagc aaagaaattt 1418941 tgcgatttcc attgggattt ttgaaaacgg tgaaggtaaa atcggtttaa tttatgatgt 1419001 ggtgcacgat gagttgtatc acgcatttag cggcagagga gcttatatga atgaaacgaa 1419061 gctggctcca ttaaaagaaa ccgtcattga agaagcgatt cttgccatta atgcaacatg 1419121 ggtaacggaa aacagaagaa ttgatcaaag tgtgttagcg ccacttgtga aaagagtcag 1419181 aggcacacgc tcctacggtt ctgccgcttt agagctggca aatgtcgcgg caggaagaat 1419241 agatgcttac atcacgatgc ggcttgcgcc atgggactac gcagccggct gtgtgctgtt 1419301 aaatgaagta ggaggcacct atacgaccat tgaaggagag ccgtttacct ttttagaaaa 1419361 ccacagtgtg ctagccggaa acccatctat acataaaacg atatttgaag agtatcttca 1419421 tgctcggaag taggccattt gagcaggatg atctcagctt gttagaaaag ctcgcggagg 1419481 ctcatcctgt atggaaagag gaggagtttg gagataaaga tgcagaagac tatatcattt 1419541 cctactccat gtacaacggt tcatggcttg tatgggaaaa agacggtatg cctgttgccg 1419601 tcagctacca tctcgagtgg tctccttcaa acggtaagcc gtggctcgga acggtcctga 1419661 ttgacccggc tgaagaaaaa aagggacatg cgaagatgat cattgaacag atcagcaaat 1419721 tgcttagagc gaaacataaa gcgatgtttg cgggagttcc cattgagcgc agggaatgga 1419781 tactgttttt aagccaatgc ggctttgaac agctgaaaac ggaaaaagat gagaaaggca 1419841 aatcatttat gatcttggtg aagcctttag cagaagctgc cgtatgataa tggcagctta 1419901 tttgctgcat gcgggttcaa taaaaagcct ctcaaacatt gagaggcttc tgatgatttg 1419961 aaaattattt ttttaccgca tgaatataat gaatcgtttc aaacgctgac aaattgtctt 1420021 ttcgattact aaagaaaagg tcattgatgt cgtctggtga tagatgttca tagatcagta 1420081 aaccagatga ctctaacaga tgttcaatct cttgataagt gaaacatgat ttcatcggtt 1420141 ccccgcttgc ggcagccatc ttcaccatat gttcaactcg attcgacgtc ccttttgctg 1420201 taaaaagtgt ttcgtccgca taatcaaaaa caatagagct tccaggcggg acatgagaaa 1420261 ataaattgct gatcaagctt gcattttctt cccgtgttac ataataagac actccgagaa 1420321 ggctgaagaa tgtttttgtg tttttaaatc cttcatctaa gagaggatca tacgaaaacg 1420381 ttttggtgaa atccatagga acaaaatgaa gatgacccgg aattgtcaga tttgcatcct 1420441 tcagcttatt ttttttcaat tgctgtgtgg ccggatgatc aacctcgaaa acctgtaagc 1420501 tgttttctaa ttctggatgc cgaaagcaga aagtatccag tcccgctcca agaatgacat 1420561 actgttttgc ccccaggatt aattcgttgt gcaagacttt ttcacaataa gaagcacgtg 1420621 ctaggggcgt tggagacagc tggatttgtg caacccattt taatattttt tcaggatcat 1420681 tttgaagacg ttcggcgatc tctttgttga aaaacgatat ttcttgaatc atatttttac 1420741 tgatgtcgat aaactctttt tcgttaatga gatcttttgc gataaaatca tcaaaaataa 1420801 gaggtgtgtc atatcggctg tgatatgcac gggcaaaagc tgaaattaga gacgttaagc 1420861 tggactcatt tttcctcatg aaatgatcct ccacaaaaaa taagattccc ctggccagga 1420921 gaatcttatt atacatacaa atatattaat agtaaatttt agcataaata aatttttttg 1420981 tcaatgtttt tgctcttaac tggacgcgcg atccttcaca tagccacgtg acctgtagca 1421041 gaattcgtct atcaattatg tggactgaat cattagcttt tataaaatgc gcacttgcgg 1421101 ctgcatccct ctttatgcaa atcaggagcg gttttctgtc tcatggcagc atcttttcgt 1421161 cgtttcagct gagagagaaa tcaagatatg taacaataaa agcctgaggg atctcaggct 1421221 tttcctaata ttacaatcca acagcattcc aggctgcttc aactttagcg gcatcagttg 1421281 agccgtagag gtcacgggca gactgaatga gagctgcctt ggcatctttg aacgtggaag 1421341 aaggcgtgag gtacgttgtt aacgcacggt aatagatttg ctgtgattta gatacaccaa 1421401 gttttgtgat ggtgttgtaa gcggctttgt ttggaattcc gctgtttgtg tgtacaccgc 1421461 cataatcgcc ttcatctgtg tttggaaggt ttcggtaatt ggcgtaattg tcaggctggt 1421521 tgtattttgt agggttggac aggctgcgaa gagcaggctg gctgaccgta atgtcttcac 1421581 cgatgtccca gtcttctgta tcgttaaaat acccgaatac gtcagagaaa gactcgttta 1421641 atgcacctgg ctgattttca taaatcaagt tggctgtttc ttgggtgacg ccatgtgtca 1421701 tttcatgcgc tgtcacatct aatgagccgg aaagcggaga gaagaatgaa ccgtcgccat 1421761 caccgtaaat catctggtct cctgtccatg cagcgttatt gtattgagtg ccgtagtgaa 1421821 cggaagaaac gattttactg cctttgttat catagctgtt tcgtttaaag tttgaataaa 1421881 aataatcgta cactttaccg aggttatagt gtgcgtcaac ggctgcccgc tgtgatgaag 1421941 atgtaaatgt tttcgttgtg cttgagacaa gcgtgcccgg aaggcggctt tgtctgtttt 1422001 gcaaatcata tgtgatgatt tgggtgcctg ttggttttga aagatctctt agaacatatt 1422061 ttccgccttc ataagagatg ttcaaaggaa cagttgcgcc ctttagcgtt gttccgcttc 1422121 cagtggcggc ggcatgttct actttatttt gctgttttaa aatgctgcct gtttcggcgt 1422181 caactaagac ttcccagttt gcaggttcag gctcgacata gcgaatcgtc acgtcgtaag 1422241 caagacgata gctgccgtct tttgtttcta tcgcttttaa ttcggcttta ttgctgtttt 1422301 tggccgctcc gttagaaaca gcgtctggtg atttgccgat agctttgaaa gcgagtgcca 1422361 gcgctttttc agaagagact ttttggctgt tatctgtttt tgcagcagat tgattgtgta 1422421 attcaccatt gaccgcatag acattatcgg atttatcgac gtgaacgatc acttgcgaat 1422481 ctttaattgg cactccgtta acgacaggcg catatcgaaa gtgcttgtat ccaagggcat 1422541 cagtcgtgct ttcaacaagc ttcagccttt tggaagggtc acctttaaaa atgttgctgt 1422601 tctttttcaa aaactgcttg acagccttgt catttggtgc agagagttct gattgcgcaa 1422661 tcgcgttttt ggagaggaaa tttgtttgat tctctttaag ctgatgacct tcagcagcct 1422721 gaacacctgg caggctgatt gataaactca taaacgaagc agcgacagca acagacaatt 1422781 tcttacctaa acccacaata aatccccctt tttgaaaata ctgaaaactt tatattgtta 1422841 tattaaacta gcattctgga atactcaaca aaaactaaca taactagaca aaattgatag 1422901 tattgtcctg tgtttgtttt tgttgaataa tatcaagatg agtcaagtgt catgtggtgg 1422961 ttcattcaag agttatgttt tttacatatc aaggggaaga tgagatattt ttgtttcatc 1423021 ttgaaacttt ttgaaaagtc cgctgtctaa ccgaatgagg ccttaataag aagtaaagga 1423081 ttgttgttcg tgttggagtt attcagtcat tatgtattgc atttcgaacg ttattttata 1423141 ttaagcagac aaagcaccct gctgattcaa tggtcaattg ttgttctggc gggcttatat 1423201 cttttggtgc atcatcccaa aataaaccgg cagcgcacaa tgttcttggc gggtgttata 1423261 ttgcggattg tgctgctggc gggagtgtct gttgaactta ttcaccaggt gcaatcaaca 1423321 aacttcacca gcgcttactt aagagaggac ggaaaagaac tgctgccgct gctgcatttt 1423381 ttgttatacg gatatgtgct gctgacggct tttcactata tgctgatgcc gcgtgatcat 1423441 ggcggaaagg gtaagtttta tacgttcgac cttgctgttg tcagtttgcc gatcgtacaa 1423501 atgattttta gtttcttttc gtattggaag gaatacccgg atgggatgga gccgattgca 1423561 ttcgtgtttc tgtttttcat catcactctt cccattgcgt tgaatgtagt gtttttcaag 1423621 ctgtattgga gaacggataa gatcttacta ggcttatttt atacgctgat tatcggactg 1423681 cttgtcttgc tgcttgcgcc atatcccaat caaatctcaa aagattatgg tgcagtaatg 1423741 ccatatacga tttatttggc aatggcggga tttttgatga gctatcatct gttccaaaag 1423801 tcaggaaagg tttatgtgcg tgtgaataag tgggtgacga tggctgtcat ggtgtttttt 1423861 gtcctgctgt taaatccgat atataacata ggaacggctg ctttcgctgt atcaaagcca 1423921 gcaaatgtcc atgattcatt caattttgtc ggggagcaca tttcatcaga aaaagcggaa 1423981 cagatactaa agtcattttt tcctacggat gaaacacttt atttgcacga tacaaacatg 1424041 gatgtgcatt atttctactc atttgaaagc aaaggttaca aagctgaggt agatgaagta 1424101 tcgcagctaa ttcgtaatta tgaatactta caaaaagcac atgggaaaaa gctaacgaat 1424161 caggagtaca agcgaaagtc catcgctttc cttgagcgac acggacgtgt gttacataag 1424221 gatcatatcg aaacaaaggt atctcaagaa gacggccaga cagtcgtacg tatttacctg 1424281 aaaaatcaac ttcataaaaa agatcatgct gatgatggcg cggtatttta ttgggaaaag 1424341 gaaaccttaa tggggtttag tgaagatcct tcgatttatc agcttgactc tcttctgcat 1424401 gttcatataa cggaacaaga cattcacgac aaagtggaac aaatgtttac agcgctgaac 1424461 atatcaaaac agccttatca gatcactgat attgaaagcg acagcctgct tggaagcatg 1424521 gtgagagttg aaacaaaagt tggaattgtt ttggaatttg agggcgaatc aggttgttta 1424581 catagtcttt cgcttccgat gaaaaagaat atctcaatgg ctaacagccg gctgcagcat 1424641 cagatattat cgatcttcga tgctcgtgga tcagaaaaga agaaaaaaag cagtcagggt 1424701 gacatggtga tgtatactga ttcttctaaa acatatgagt ttgttgaagc tcaaggtcag 1424761 ctaaacgttt atgtatacag cgatacacct gatcagtcat tcccctatac gtatcgtaat 1424821 ggaacattgg cttacgaaaa agtagcttct ctatatcagg atgtcattta caaaaagcgt 1424881 atgcgtccga ttatcgttca aagaggggat gaacggcatt atgcatggct gatcattatt 1424941 cagccgtttg gttcaaatcg ccatgatgcc tatgtagtgg atggagaaac acaagaggtg 1425001 aaaagtcttt atgaatcata aagaaaaaga gtctgttttt gtagacttat acgacctgta 1425061 taaagaagga gagctagagg atgaatcaat ggaatggatg aaacagcatg aatccctatt 1425121 tcaaaagaat gcggaagact taaagagtaa aacttgttta aagagaagtc ccggtgctga 1425181 agaagaaagc caaatcagat atatgaaagt atacctgtct tccatgtata tctgtttcat 1425241 tttattggcc atttggatga cggtgtggtt ttatttttaa tgaagcatag ggattccatt 1425301 gaggacttgt atcggcagta ttatcaagaa attttaaatt atttattcag aaggactcat 1425361 catcttgaaa cagccaagga cttagcgcag gacacgtttg taaaagctct taacggtctg 1425421 gcttcgttta gggggcattc ttccatcaga acatggctct acaccattgc gcatcatacc 1425481 tttatcaatt ggtaccgaag ggatgtcaaa taccaattta ctgaaatcag caaaaatgaa 1425541 gggttaacgc aaacaactta tgaccagcct gaacagtatc tgtcacggac ggtgaaaagc 1425601 gaaacactgc ggcaggagct cctgaagtta aaagatcagc atcaatccgt tttgatttta 1425661 agagaattcc aagagctttc ttatgaagaa atcgctgaga tattaggatg gagtctttct 1425721 aaggtgaata ccacattgca ccgggctaga ttagagctaa agaaaaacat gacgaaaagt 1425781 agagaggagg agcggatatg acctgctttc tagtaagaga cctgcttcct ctgtatcttg 1425841 aaggtgattg taaaagagaa acggaacacg ttatagaaga gcatttaaaa atgtgcagca 1425901 gctgcagaga catgtatgac acgatggctg agccatttga attggaaagc gaacaggccg 1425961 ttgaggaggc ttatctgccg gaagaagaac tgcgttttaa acagaggtac tatggattac 1426021 tgatcatgaa agctgcctgc tggtttggag cggcggttgc catgatgctg atcatcaaac 1426081 tgctgatata aaaaaagcgc ttgtccgatt ccggcaagcg cttttttaca ttaagcctgg 1426141 ggatgaatca tatcgtaaat agcggcaagc tgttcttgtg acagggcact gaagagtttt 1426201 tcataaacgt cagcttgcag tggcgttgca cctgcttgta gcgctgcgtc tttatcatag 1426261 ctgtacacat catcttgtag cacaatggct gcttgaagaa tgtgaatctt gagagaaaca 1426321 gcggagaaaa attgttcaag tgcaagtgct tctttttctg tgaagccaag ttcaactgct 1426381 ttttctgtat caaatttgta atttccatcc tcgagataca cacattgtga aacaatgctg 1426441 aaaaattctg atgtcgattc ccagagtgta gcaattacct gagcctcttc ttttgtcatt 1426501 cctaactcga cagctttttc gctgtcaaaa taatatacac cgtcttgttc gtatatacat 1426561 tgatttaata tatcaatgaa tgtattgaga tcttcgttag tgctcgcctg atgctggagt 1426621 tgaacagcag tgttatcaac cggtgttttt gcgctggctg catcaggacc gaacgttaat 1426681 agagcagctg aggtcattgc ggcagtcgtt aacatagctt tttttacaaa tgttttcttc 1426741 atgtttcttc tctccctttt atgaattgtg ctacaaattc cattataggg agtagtttcc 1426801 ggtggaggaa taggcgctat ggtattttat gtgtatcgtt gccgaactac tttttgaagg 1426861 ctgcacgtgt gatcgttaga acgattgtct atgtatgaag gctgttttgc atcttcctga 1426921 ctaagaaaca ggggagataa ggcttaaaga aatgaaaaac accgctttct ttgcggtgtt 1426981 ttttgattac aatgtcgccg gcggggcaat gcttttaatc aagcaagcct tgttcgcgca 1427041 ttttcttttt taatgtaaat ccgccgccca tgacagcgca aacaagtaca atgctggcga 1427101 taatgcctgc agggcttttt tcagcgataa agacgccgat cagcataatg ctgaaaaccg 1427161 ctgcaaatgc aaataatagt aaaagccaat tcattttttt cataaattcc atcccctttt 1427221 acgtcttata ttaagtttac agaaaaacgt gacgctttta aagaggatgt gtgatataat 1427281 atgaaagtta tctaattttt ttaggagatg aaaaagtgaa acttcgaaat gatcttcgca 1427341 acatcgcgat tattgcccac gttgaccatg ggaaaacgac tctagtcgat cagcttttac 1427401 atcaggctgg tacgttccgt gccaacgaac aggttgctga acgcgcaatg gactctaatg 1427461 atcttgaacg cgaacgcggc attacaatat tggcgaaaaa tactgcgatt aactataaag 1427521 atacacgtat caatattttg gacacccctg gacatgcaga ctttggggga gaagtagaac 1427581 ggattatgaa aatggttgac ggcgtagtgc ttgtcgttga cgcatatgaa ggctgtatgc 1427641 ctcaaactcg ttttgttctg aaaaaagctc ttgagcaaaa cctgaaccct gttgttgttg 1427701 taaacaaaat tgaccgtgac tttgctcgtc cagaggaagt tatcgatgaa gttctggatc 1427761 tgttcattga gcttgatgcc aatgaagagc agctcgagtt cccagtggta tatgcttccg 1427821 cgattaatgg aacagcgagt cttgatccga aacaacagga tgaaaacatg gaagctttat 1427881 atgaaaccat tattaagcat gttccggcac ctgttgataa tgcagaggag ccgcttcaat 1427941 tccaagttgc ccttcttgac tacaacgact atgtaggccg tatcggaatc ggacgcgtat 1428001 tccgcggcac aatgaaagtc ggacagcagg tttctcttat gaagcttgac ggaacggcaa 1428061 agtcattccg tgttacaaag atttttggtt tccaaggctt aaagcgtgtg gaaattgaag 1428121 aagcaaaagc gggagacctc gttgcggttt ccgggatgga agatatcaac gttggtgaaa 1428181 cggtatgtcc tgtagaccat caagatccgc ttccggtcct tcgcattgat gagccgacac 1428241 ttcaaatgac atttgtcgtg aataacagtc cgtttgcagg ccgtgaaggc aaatatgtaa 1428301 cggcccgcaa aatcgaagag cgtcttcaat cacagcttca gacggatgtg agcttgcgtg 1428361 ttgagccaac agcttctcct gatgcttggg ttgtttcagg acgcggtgag ctgcacttgt 1428421 caattttaat tgaaaatatg cgtcgtgagg gctatgagct tcaagtgtca aaacctgaag 1428481 ttattatcaa agaaatcgac ggcgtacgct gtgagcctgt tgaacgtgtg caaattgatg 1428541 ttcctgaaga gcatactggc tctgtaatgg aatcaatggg tgcccgcaaa ggcgaaatgg 1428601 ttgatatgat caacaacgga aacggccaag tccgtctcat ctttacagtt ccttcccgcg 1428661 gattgatcgg ttactctaca gaattcctat cattaacacg cggattcggt attttgaacc 1428721 atacgtttga cagctaccag ccgatgcagg caggccaagt cggcggacgc cgtcaaggtg 1428781 tacttgtgtc aatggaaaac ggaaaagcaa catcatacgg tattcaagga attgaagacc 1428841 gcggtgtcat cttcgttgag ccgggtactg aagtatacga aggaatgatc gttggagagc 1428901 ataaccgtga caacgacctt gttgttaacg tcagcaaaat gaaacagcaa acaaacgtcc 1428961 gttctgcgac aaaggatcag acaactacaa ttaaaaaagc gcgcatcatg tctcttgagg 1429021 agtctctaga gtacttaaac gaagatgaat attgtgaagt aacacctgaa tccatccgtt 1429081 taagaaagaa gatcctcaat aagaacgaac gtgaaaaagc agctaaaaag aaaaaaacag 1429141 caggattgtc ttaatctcgt gcagaatttg aaaagataga acccgtacgt ttacagggga 1429201 gggaatcttt ttgaatgacg taagcgaacg cctgtcgttc ttcgccgctc tatatcaagt 1429261 agaccggcag cctgcggcag gcatgtggct gctgtacggc acgatttttg tgttggccgt 1429321 tattgtattt aagcttggat ttgctaaacg gcttcctgta ttaaaatctg cagtggtgta 1429381 tgtatttttg gctttgggct gcactgtttt gactttttta ggggtgtttt tgcccgtggc 1429441 agaaggattg gtcgtcgctg cgctgatttt aatcatttac aaaatccggc tgtatcagtc 1429501 gaaaaaagga cagtctgcaa aatcataaaa gactcagctg aaagctgagt cttttttgtg 1429561 ttctgtatgg ttaagcggcc gctttatttt ttgacttttt cttttttctg ctgtcccggg 1429621 tgaaaagtaa attttcccgt tttcagccgt tcctctgttt ttttggcaat ccgatcgtgg 1429681 cattcctggc acatatatgt atggatcggg cggtttcgaa gccgtttcgc gatcagggta 1429741 tcatcatcaa ttgtttcaat tttatcgcaa atagaacatt tgaccctcat catatcacct 1429801 ctttcactaa catgtattat accacggatc agaagctgtc caaaataaga aaaagctaaa 1429861 gcgcaaggct atagcttagt cattgttgtt ctttttcata tgatgatcag attgatcgtt 1429921 ttgttccttc tccatttcct gttgctgttt tctatttaat tggtcatttt gctgctttgt 1429981 ttgcggttca tcttcattgt caatcacatc gttaggcact tcgggaagca ctcggccgac 1430041 aattgcagct aattcatcca gtatacctgt taccggatgg ccctcgctga tttctctgct 1430101 catttcgcga aggcggctga ccgtatcggg atcagcaatg actactgcgt tggcgccata 1430161 tcgatcattc tttagcgcct gagctacaga atatttaatg gtttccactt tgcttctgtc 1430221 caaagtatca tcgacatcaa tcccaacaac agcatagcct cccagcacaa cggctgttgc 1430281 atccttgacg tcggggtttt tttcagcaac gctgacaaga tgcttggcaa tatccgttct 1430341 tgttccattg tcttttgttt cttgagttgt gtcctttacg tgaatcggtt tagtctcctg 1430401 ctgtcttgtt gattcttttt caacattctg gccctgtttt ccttgttgat aggcacaagc 1430461 ggacaggata agtgtcagct gtatgataat gaaaagaatt cgcacttgcg ggttccctcc 1430521 ttaaaatgct ttcattaatt ttattgttga attaaccttc tatctttatg cacaaaaaca 1430581 tatattttag caggcattca cctttttcat caaaagagaa gcaggaagaa ctttgaccct 1430641 tatatcagga ggctgagact tgagtaaaat ttatgtgtta gatacgaatg tgttattaca 1430701 ggatcctaac gcgatatttt cttttgaaga aaatgaggtt gtcatccctg ctgtcgtttt 1430761 agaagaggtt gattcaaaaa aacggtatat ggacgaagtt gggaggaatg caaggcacgt 1430821 atctaagcta atcgatgcgc taagacaaaa gggcaggctg catgagcatg taccgcttga 1430881 caccggcggc acactgagaa ttgaactgaa tcatcgttcg tttcaccagc tgcaagagat 1430941 ctttattgaa aagacgaacg ataatcgcat attagccgtt gcgaaaaact taagcctcga 1431001 ggaagaaacc aaggaaaatg gcaggccggt tatccttgtc agtaaggatg tactggtcag 1431061 ggttaaagcc gacgcaatcg gactgcttgc tgaagatttc ttgaatgacc gggttgtgga 1431121 caatgatgaa atgtacagcg gctataaaga tttatatatc agccagcagc tgttcagctc 1431181 tttttacggg aaaaatcaaa tttcagtaaa cgatgtgaaa cagcatgcgt tttatccgaa 1431241 tcagtttgct ttaatgaagg atgagctagg agggtcctcc tcggcagtcg gaattgcaga 1431301 caaaaccgga acggtattaa aaagactcgt atttgatgat gaacatatat ggggaatcag 1431361 gccgaaaaat gtacagcaga caatggcatt agagcttttg ctgcgggaag atattccgct 1431421 tgtcaccctg atcggcaaag cgggaaccgg caaaacgctc ttagctttgg cggcagggct 1431481 attacagaca gaagacttgg gaatatataa aaagctggtc gtcgcaaggc cgattgttcc 1431541 tgttggcaag gacatcgggt atttgccagg cgaaaaagag gaaaagctaa agccttggat 1431601 gcagccgatt tttgacaact tagagtttct gtttaatgcg aaaaaaccag gggagcttga 1431661 tgctattttg gcgggaattg gctcaattca ggtagaggcg ctgacttata tcagagggag 1431721 aagcattcca gatcaattta ttatcattga tgaagcgcaa aatttgacca ggcatgaggt 1431781 gaaaacgttg ctgacgagag tcggtgaggg cagtaaaatt gtcttaatgg gcgaccctga 1431841 acaaattgat cacccatatt tagacagtct gaacaatggt ttggcctatg tggttgagcg 1431901 gtttaaagga caacccatct caggcagcgt gaagctgtta aaaggtgaga gatcaggtct 1431961 cgcccagctt gcagctgatt tgctgtaaca cttaaatgat ttcgatctct tttacatcgg 1432021 taatcggctg tttgtgatga accgggtctt caaagtaaat atgcacgggg ccgccttctt 1432081 gaatcggctt gcctgcctca ctgaaatgga caatactgtt cagagcggtt tccagagaaa 1432141 cggcggcctt tcccgaactt gtgacaaata cacattgtgt cgcagagctg ttcggctcag 1432201 catttttcag gacagtccca agtctcattg cgaaactgcc gttcatcagt ttttgcttct 1432261 catattgctt ttccgtcttt aatgtaggcg gcgcgattcg cccctctctg atgacgcgtt 1432321 ccggatcaag gtcggattca tccccggctg attgtaaata tgtgtcttga ctgtcccctt 1432381 tgcggtcaaa cgaaaatttg cgatcatcaa aaatccatac gcttggatca atggtaattg 1432441 gatatgtaac attgcctttt acttggataa cgctcatgat atgaccccct tctctcaaaa 1432501 ttataaaagt tttcgcatga attgtcactt tgtgtacaaa ttatgtgtat tgaaatgctg 1432561 agggaacgag ggtgtttgca tggtatgcca gcataatgat gagcttgaag ccttagtgaa 1432621 aaaggcgaaa aaagtaacgg acaaggggga ggtagccagc tatattcccg ccttggcaaa 1432681 agctgataaa cacgacctgt cagtggcgat ttattattcc aataatgttt gtctgtcagc 1432741 aggtgacgta gaaaaaacat ttacgcttca aagtatatcg aaagtccttt cccttgcttt 1432801 ggtgttaatg gaatacggca aagataaggt cttcagttat gttggacagg agccgaccgg 1432861 tgatccgttt aattcaatta tcaagctcga aacagtgaat ccgagcaagc cgttaaaccc 1432921 tatgattaat gccggggcat tggtagtgac aagtctgata aggggaagaa cggtaaaaga 1432981 gagacttgat tatttgcttt cttttatcag aaggctgaca aacaaccaag agattacata 1433041 ctgccgggaa gtggctgaat ctgaatacag cacttcaatg attaatcggg cgatgtgtta 1433101 ttatatgaag cagtacggca tttttgaaga tgatgtagag gcagtaatgg atttatatac 1433161 gaagcaatgc gcgattgaga tgaacagctt ggatttagcg aaaatcggat ctgtattcgc 1433221 attgaacggc agacatccag agactgggga gcaggtcatc tcaaaagatg tcgctagaat 1433281 ttgcaaaacg tttatggtga cgtgcggaat gtacaatgca agcggggaat tcgcaattaa 1433341 ggtcggaatt cctgcgaaaa gcggcgtatc cggcgggata atgggcattt cgccttacga 1433401 tttcgggatc ggcatattcg gccccgcatt agacgaaaaa gggaacagca ttgcaggtgt 1433461 aaagcttttg gaaataatgt ctgagatgta caggctgagt attttttaat ttatgtcata 1433521 tgcttaaatc ctcttgcatt ttctgttgat accctttatg ataaatagaa gaattaggta 1433581 ctcgcctggg gaacggaggg atacttttgg cttcagagat gatagttgac catcggcaaa 1433641 aagcttttga actcttaaaa gtggacgctg agaagatttt gaagctgatc cgagtacaaa 1433701 tggataactt aacgatgcct caatgtcctc tatatgaaga ggttttagat actcaaatgt 1433761 tcgggctttc gagggaaatc gattttgctg tccgcctggg attggttgat gaaaaagacg 1433821 gtaaagacct tttatacaca ttggagcgcg aattgtctgc tttgcatgac gcgtttacag 1433881 ctaaataaat gataaaactc aaacttatta acagtttggg tttttttata accgctattt 1433941 ttctctcatc tcataaaaga cggtcttttt ttacacattc cttccgaatc gtatagagat 1434001 tcttcgtctc gtttgataaa ttgtagtaaa ataaaaaaga taaatacata aaaaccatag 1434061 ataatggaag ttagaagcag ggaagaggat gttatgttaa aaaaaatgct aaaatcttat 1434121 gattactcac tgatattcgc aatcgtttta ttatgcggat tcggtttagt gatggtatac 1434181 agctcaagca tgattacggc tgtctcccgg tatggagtaa gcagtaattt tttcttcatg 1434241 cggcagctgt ttgctttaat tgcgggtggc gctctattta ttctcatggc gttgtttcct 1434301 tataaagcac tggcccatca aaagtttcag aaggggatac tgcttgtatc tgttcttgcg 1434361 cttatctcac tgtttgtttt cgggcatgtt gccggaaacg cgcagagctg gtttaaaatc 1434421 ggcggaatga gtattcagcc gggggagttt gtgaaactgg tcgtgatttt ataccttgca 1434481 gccgtatatg caaaaaaaca aagttatatc gaccatctgt taacgggagt agcccctccg 1434541 gtagtcatga cgcttataat ttgtgggtta attgccatgc agccagattt cggtacagcc 1434601 atgattatag ggttaattgc gacgtgcatg atcttgtgct ccggcttcag cggaaagacg 1434661 ctggtgaggc ttgtgatact gggcggaatt gttttcattt tagtcagccc tattatctat 1434721 ttgaatcagg acaaaatttt aactgaaggc cgtttagcgc gttttgagag tcttgaagac 1434781 ccatttaagt atgcaaattc atcaggtttg caagtgatca attcttatta tgcgatcagc 1434841 tcaggcggca ttttcggcct ggggctcggt gaaagtatcc aaaaatacgg atatctgcct 1434901 gaatcacaca ctgactttat tatggctgtc attgctgaag agctcggcat ttttggggta 1434961 ttgtttgtga ttttcttatt gggttttgtc gtcataaaag gtttttatat tgccagaaaa 1435021 tgcgaggacc cgtttggaag tcttctggcg atcggcattt caagcatgat tgccatccag 1435081 tcgtttatta accttggcgg tgtcagcgga ttaattccga ttacaggggt tacgctgcca 1435141 tttatcagtt acgggggctc ttctttggtg ctgctgctgg ggagtatggg gatattagcg 1435201 aatatcagca tgtttgtgaa atattcagag aataagaaaa agaaagagcc cttggcgccg 1435261 aagggaatga aaaagaaaca gctcaaaaaa actgtttatc tgtaaaaaac aagtgtgtac 1435321 aggggaagga tattccgcta tgatagatta tattccattc gggtaagggg gagaaaagtt 1435381 tgtctcagca atcgatacaa aaagtattag tagcaaacag gggagaaatt gcaatccgaa 1435441 tattccgggc gtgtaccgag ttgaatattc gtacagttgc ggtctattca aaagaagatt 1435501 ccggttccta ccatcggtac aaagcggatg aagcatactt ggtcggtgaa gggaaaaaac 1435561 cgattgatgc ttacctggat attgaaggta tcattgatat tgcgaaaaga aacaaagtcg 1435621 atgcaattca tccgggatac ggtttcttat ctgaaaatat tcattttgcg agacgatgtg 1435681 aagaagaagg catcgtattc atagggccaa aatccgagca tctcgatatg tttggtgaca 1435741 aggtaaaagc gcgtgagcag gcagaaaaag cgggaatccc cgtgattccg ggaagcgacg 1435801 gtcctgccga aacgcttgaa gccgtcgaac aatttggaca agctaacggt tatccgatca 1435861 tcattaaagc ctcgcttggc ggcggcggcc gcggtatgcg gattgtcaga tctgaaagtg 1435921 aagttaaaga agcatatgag cgtgctaaat cagaggcgaa agcagccttt ggcaatgatg 1435981 aagtttatgt agaaaaatta attgagaatc cgaaacatat tgaggttcag gtcattggag 1436041 acaagcaggg caatgtcgtc catctttttg agagggattg ctccgttcaa agacgccatc 1436101 aaaaagtcat tgaagtggcg ccgagtgtct cgctgtcacc tgaattaagg gaccaaattt 1436161 gtgaggctgc agttgcgctt gccaaaaatg taaactatat aaatgcgggg acggtcgaat 1436221 tccttgttgc aaacaacgag ttctacttta ttgaagtaaa tcctcgcgta caagttgaac 1436281 acacgataac agaaatgatt actggtgtcg atattgttca aactcagatc cttgttgccc 1436341 aagggcacag ccttcacagc aaaaaagtaa atattcctga gcaaaaggac atttttacaa 1436401 tcggctatgc cattcagtca cgggttacga ctgaggatcc gcaaaatgat ttcatgcctg 1436461 atacaggaaa aatcatggct taccgctcag gcggcggttt tggtgtccgt cttgataccg 1436521 gaaacagctt ccagggcgcc gtgatcacac catactatga ttcacttctc gttaagcttt 1436581 caacttgggc tttaacgttt gaacaggcag ctgccaaaat ggtgcgaaac cttcaggagt 1436641 ttagaatcag aggcataaaa acgaacattc cgttccttga gaacgttgca aagcatgaga 1436701 agttcctgac agggcaatat gatacatctt tcattgatac aacgcctgaa ttatttaatt 1436761 tccctaaaca aaaagaccgc ggaacgaaaa tgctcactta catcggcaat gtgacagtga 1436821 acggcttccc tggaatcggg aaaaaagaaa aaccggcgtt tgacaaaccg ttaggcgtaa 1436881 aggtagacgt tgatcagcag cctgccagag gaacaaagca aattctcgat gaaaaaggtg 1436941 cagaagggct tgcaaattgg gttaaggagc agaaatctgt ccttttaact gatacgacat 1437001 tcagggatgc ccaccaatcg ttattggcaa ctagaatcag atcgcatgat ttgaaaaaaa 1437061 tcgcaaatcc gacggctgcg ttatggcctg aactattcag tatggaaatg tggggaggcg 1437121 cgaccttcga tgtagcctac cgattcctga aagaagatcc gtggaaacgt ttggaagatc 1437181 ttcgcaaaga agtgccgaat accttattcc agatgttgct tcgctcatca aatgcggtcg 1437241 gctatacgaa ttatccggac aatgtgatta aagaatttgt gaagcaatca gctcaatccg 1437301 gtattgatgt gtttcgtatt ttcgacagct taaactgggt aaaagggatg acgttagcca 1437361 ttgatgctgt tagggatacc ggcaaagtgg cagaagctgc gatttgttat acgggagata 1437421 tccttgacaa gaaccggacg aagtacgacc ttgcatatta tacatcgatg gcgaaggagc 1437481 ttgaggcggc cggagcccat attctcggga ttaaagatat ggcagggctg ttaaaaccgc 1437541 aggctgcata tgagctcgtt tctgcgttga aagaaacgat cgacattccg gttcaccttc 1437601 atacgcatga tacgagcgga aacggtattt atatgtatgc gaaagctgtt gaagccggcg 1437661 ttgatatcat agacgtggcg gtcagctcaa tggcgggatt aacgtcacag cctagcgcga 1437721 gcggatttta tcatgcgatg gaaggcaacg accgccgtcc ggaaatgaat gtccaaggcg 1437781 ttgaattgct gtcccaatat tgggagtcgg tgcgtaaata ttatagtgaa tttgaaagcg 1437841 gaatgaagtc tccgcatact gaaatttatg aacacgaaat gccagggggc caatacagca 1437901 acctgcagca gcaagccaag ggagtaggcc ttggcgaccg ctggaacgaa gtcaaggaaa 1437961 tgtacagacg cgtgaacgat atgttcggtg acatcgtcaa ggtaacgcct tcctcaaaag 1438021 tagtcggaga tatggcactc tacatggtgc aaaacaatct gactgaaaaa gacgtttacg 1438081 aaaaaggtga atctttagat ttccctgatt ctgtcgtgga gctttttaaa ggaaatatcg 1438141 gccagcctca tggcggattc ccagaaaaac tgcaaaagct gatcttaaaa gggcaggagc 1438201 cgattacagt cagaccgggc gaactgcttg agccggtgtc atttgaagcg atcaaacagg 1438261 aatttaaaga gcagcataac ttggaaattt cagatcagga tgctgtggca tatgcccttt 1438321 atcctaaagt cttcactgat tatgtgaaaa cgacagaaag ctatggagac atctcggtat 1438381 tagatacacc gacattcttc tacggtatga cattaggtga agagatagaa gttgaaattg 1438441 agcgcggcaa aacgctgatc gttaagctga tttcaatcgg tgagcctcag cctgatgcca 1438501 cccgcgtcgt ttatttcgaa ctcaacgggc agccgcgtga agtagtcatt aaagatgaaa 1438561 gcattaagtc ttccgttcag gaaaggctga aagcagaccg gacaaatcca agccacatcg 1438621 cagcttccat gcctggaaca gttattaagg tattggctga agcaggcaca aaagtcaata 1438681 aaggtgatca tttgatgatt aatgaagcga tgaaaatgga aacaacggtt caggcgcctt 1438741 tctcaggaac aatcaagcag gttcatgtga aaaatggtga gccgatccaa acgggagatc 1438801 tgctccttga aattgaaaaa gcataaaaaa caaagagtgt atatcaatga tatacactct 1438861 tgttttttat atagaaaatg tggagtgaaa cagatggtta gaagagatat aaggggactt 1438921 cagagattat agagtactgt cacaagccca aaataaaaag aggcttatac agccaatatt 1438981 ttagatgctt tgtagtatgc cgtgcatatt tctttaagca ctatctgatt taaaaggctt 1439041 taatacttat gttcgcgagc tatagatcca tatgaaattt ctataatcac gatgagaaag 1439101 gggacagacc gaagtgagcc gctcactgat catcaagttc ggcgaaggct ggcgattgaa 1439161 acgcataaag cgccaaaaaa caagacataa aaaagaccaa agccgcctaa ggctttggtc 1439221 ttgagtcctt atgattgcct ggattcataa cggaaacgag caatcaataa taagaagtag 1439281 catagaacgc caaacagaca ggcaataaag aacgagtggg caagtgcaaa gcccagagcc 1439341 agttcagagt atacgatcat aataccggac agtgcctgta atgtaatgaa aataagacat 1439401 gagatccatc cccaaaagat ctgtttttga tctttatagg aagtaatagc atgaacagcg 1439461 gcaacaataa tccatacaaa taaaagtaag gctgctgctc tgtggcccat ttgcacccat 1439521 tcatggaatt gggtcggaag tccattgttc agcgggctgc acagcggcac attaggacat 1439581 gccagacttg attcagtgtg tcttacatat gcgcctgtat acacaacgat ataggaatat 1439641 attaaaattc ctatcatgtg aaattgcatc tttttgccga tttgaagcgg cttaaccagt 1439701 gttctgactg atttatcagc ttcaaatatg agcaatgtta aaataagcac tgaagcaaaa 1439761 gaaattaatg agatgccgaa gtgaagcgcc ataatcagcg cgttcgaacc gaatacgaca 1439821 gccaatgcgc caagcaatgc ctgaagaaat aaaaagataa ttgacatgat cgcgagaaac 1439881 gttgtttcac gaaaaatcgg cgtgattttt ctccatgacc aaaacgcaag gcttagcaca 1439941 aggataatag agattccgct tgcgaatcgg tggctccatt caataattga agccggattc 1440001 agttcaggga aaaaacggcc gtgacacagc ggccactgtc tgccgcatcc ttggccggaa 1440061 cctgtttttg taacgagggc acccccgatt aaaacaatta gcatgacaaa tgtcgtcaga 1440121 acaccgagag cttttaatgc tttattcata caatattcac cttcttaaca tactgctgca 1440181 attttatata cgttccaagt gtaagcgaat atgtgttttg tggcaattcc cagagccttt 1440241 tgttcacaaa aatataatag aatgacggct tctggaaaat gtacacttga ttattcatgc 1440301 cgggtctgat agaaataagg taaacgcaat gccgatttgg agattgcctt catctttggt 1440361 aaaattcata aaaagttcac aaataaattc ctgtttgtcg tttaatattt aataggatgt 1440421 ttttttacaa gatgttatct tgtatgatag agttgcaggt tattttattc tcctgcgtta 1440481 ggtttgtaag ggaggtttac gttatggcta actccagaat cttaaatgat acagctatag 1440541 acggacaaat tgaagaaaca acggcatgga aagattttct gtcccttatt aaaataggga 1440601 tcgtcaattc taacctcatc acgactttca ctggaatgtg gcttgcactg catatatccg 1440661 gtttaagttt tttaggcaat ataaacaccg ttcttcttac gttaatcggg tcttcactga 1440721 ttattgcggg ctcctgcgcg atcaataact ggtatgaccg ggacattgac catcttatgg 1440781 agcgtacgaa agtaagaccg acggttacgg gtaaaattca gccgagtcag gcgttatggt 1440841 ctggaatttt gctggttgct ttaggattga tcatgctgct gatgacaact gtcatggctg 1440901 ctgttatcgg ttttatcgga gtctttacgt atgttgtatt gtacacaatg tggacgaaac 1440961 gccgctatac gattaacaca gtagtaggaa gcgtttccgg tgcagtgccg ccgcttattg 1441021 gatggacggc agtggaaggg aatatcggtg tcgtagcatg ggtgttattc atgattttat 1441081 ttatttggca gattcctcac ttcttagcat tggctattaa gaaaactgag gattacagag 1441141 ctgcaaatat tccgatgctt cctgtcgtat acggatttga agtgacaaaa agacaaatta 1441201 ttgtgtgggt tgcgtgcctg atgccgcttc cgtttttcct tggtagcctg ggtcttccga 1441261 ttgtcattct cggcttgctg ttaaatatcg gctggctgat tcttggctta atgggattcc 1441321 gctccaagaa tatcatgaag tgggcaacgc agatgttcgt ttactcgctt aactacatga 1441381 caatctattt cgttgccatg gttgtcttga cgcttttcta aaaaatagat atgatgcttg 1441441 ttttatcgct tcaaaataaa cgatgacaac tagtaaatgc cgccttgacc tcttgtttaa 1441501 tcaggcggct ttacttttat acatagatgg cattttgagt aaaaaaactc ataatttaag 1441561 agaagaggaa atgtaagtgc tttattggtg ataggttgga tggcgataga tttcgatccg 1441621 ctttccgcct ttgtattgac cagaaaaggg gttgggtgaa atggtaaagc attggcgtct 1441681 tattttatta ttagccttag tgccgcttct attaagcgga tgtggaaaac cttttttatc 1441741 cacgctcaag cctgctggcg aggtggctga taaacagtat gacctgacag tgctcagcac 1441801 attgattatg gtggttgttg ttgcagtagt atctgttatc ttcttttatg tgattgtgag 1441861 attcagaaga tcacgggtcg gtgagaacac gataccgaaa caggtagagg ggaataaatt 1441921 tttagaaatc acatggaccg tgatcccgat tttgctgctc attattcttg tgattcctgt 1441981 tgtattatat acgctggagc tagcggacac atcaccaatg gataaaaaag gccgcaaagc 1442041 tgaggatgct cttgtagtca atgttagggc aaatttatac tggtgggagt ttgagtaccc 1442101 tgattacggc attatcacaa gccaggagct gattgtaccg acagatcagc gtgtatattt 1442161 taatttaaaa gcctctgatg taaaacattc cttctggatt ccttcagttg gaggaaaact 1442221 tgatacgaat acggataatg aaaataagtt cttcctgaca tttgattcaa aacgaagcaa 1442281 agaggcagga gatatgtttt ttgggaagtg tgcagagctt tgcggccctt cacatgcgct 1442341 gatggatttt aaggtgaaga cgatgtctgc aaaagaattt cagggctgga caaaagaaat 1442401 gaagaactat aagtctacag cagagagcga tttggctaag cagggtgaag aactgtttaa 1442461 agagaaaaac tgcctgagct gccatgcggt agagccgaat gataagcgtg cagaagccgc 1442521 tagaacggca cctaacttgg cgaccttcgg tgaaaggaca aaagtggcag gggtgaaaga 1442581 ggccaacaaa gaaaatgtga aggcttggct gaaggaccct gacagcataa agccggggaa 1442641 caaaatgaca ggcacatatc caaagctctc agacagcgaa acaaatgcgc tttatgaata 1442701 cttaaaaggc ttaaaagcgg aaagcaagta gggaagaaag ggagatattg ggggaggtca 1442761 catatgttga atgcgcttac agaaaagcgg acgcgcggat ctatgctttg ggattatttg 1442821 acgacggtgg accataaaaa aatcgcaatt ctttatttag tggcaggggg attcttcttt 1442881 cttgtcgggg gaattgaagc gatgtttatc agaattcagc ttgcaaagcc ggaaaatgcg 1442941 tttctcagtg ctcaagcgta caatgaagta atgactatgc acggaacgac gatgatcttt 1443001 ctggctgcga tgccgctctt atttgccttg atgaatgcgg ttgtgccttt gcagatcggg 1443061 gctcgggacg tttcgtttcc atttttaaac gcgcttggtt tttggctctt ctttttcggg 1443121 ggcattttct taaatctaag ctggtttttg ggcggagcgc cagatgcggg ctggacatca 1443181 tatgcctcac tttcgcttca ttctaaaggg cacggcatag actttttcgt cctcggactc 1443241 caaatatcgg ggctcgggac gctgatagcc gggattaact ttttggccac gattatcaac 1443301 atgagggctc cgggcatgac gtatatgagg ctgcctttgt ttacatggac gacatttgtg 1443361 gcctcggcat tgattttgtt cgcgtttccg ccgcttacgg ttggattggc tctcatgatg 1443421 ctggatcggc tgttcggaac caatttcttt aatccggagc ttggcggaaa tacggtcatt 1443481 tgggaacatt tattttggat cttcggccac ccggaggttt atatcctaat tttgcctgca 1443541 ttcggtattt tttctgaggt catccctgtg ttcgccagaa agcgtttgtt tggctattct 1443601 tcaatggttt ttgcaatcgt gctcattggc tttctgggct ttatggtttg ggtgcaccac 1443661 atgttcacga ctggtctcgg cccgattgca aatgcgattt ttgcggttgc aacaatggct 1443721 atcgcgattc cgaccgggat taagattttt aactggctgt tgacgatttg gggaggaaat 1443781 gtgaagtata caaccgctat gctgtatgct gtctcattta ttccatcctt tgtgctcggc 1443841 ggtgtgacgg gagtcatgct ggcagctgct gcggctgatt atcagtttca tgatacgtat 1443901 tttgtggttg cgcacttcca ctacgtcatt attggcggcg ttgtattcgg ccttttagcc 1443961 ggtgttcatt tctggtggcc gaaaatgttc ggtaaaattc tgcatgaaac gatggggaaa 1444021 atttcatttg tattgttttt tatcggcttt cacctcacgt ttttcattca gcattttgtc 1444081 ggcttaatgg ggatgccgcg ccgggtttat acgtttttgc caggacaggg tctggaaacc 1444141 ggcaacttga tcagtacaat cggggcgttt tttatggcgg cagctgttat tcttctgctg 1444201 gtcaatgtca tatggacatc ggtaaaaggt gaatatgtag gtgctgatcc atggcatgac 1444261 ggacgtacgc tggaatggac cgtttcttca ccgccgccgg agtataactt taaacagctt 1444321 ccttttgtca gaggacttga tccgctttgg atcgagaagc aggcagggca caaatcaatg 1444381 acgccggcgg aaccggttga tgatattcat atgccaaacg gctcaatcct gccgctcatc 1444441 atttccttcg gcctttttgt cgcagcgttc gggctgctgt acagaagtga ttacgcttgg 1444501 ggcctgccgg tgatctttat cgggctcggc atcacattta ttacgatgct gcttcgttca 1444561 gtaattgatg atcacggcta tcatattcat aaagaggaac tgccgaacga tgataaaggg 1444621 gtgaaggcat aatgcaagtt caagaaaaat tcaccgcaga aacctttcca gcttctcctg 1444681 aaaaagtaac cctggaaggg aaaaataaat ttttaggctt ttggcttttt cttggcggag 1444741 agactgttct gtttgcgtct ctcttcgcca cgtttcttgc gcttcggaat tcaaatgccg 1444801 gtgatccgcc tacgacggaa atgttcgatg tgacacttgt attcattgcc acaatgcttc 1444861 tattaacgag cagtttaacg agtgtgtacg cgatgtacca catgaagaac ttttccttcg 1444921 gcaagatgca gctttggctg ggaattacga ttttattggg ggcgggcttt ttaggactgg 1444981 aaatctatga gttcaagcat tacacccatg aatttggctt taccatcaca agctctgccc 1445041 ttggttctgc gttttacacg cttgtcggta cacacggcgc ccacgtggca tttgggctta 1445101 tgtggatcag cacgcttatg atccgcaatg ccaagagagg gctgaatctg tatacggcgc 1445161 ctaagtttta cgttgccagc ctttattggc actttattga tgtcgtgtgg gtcttcatct 1445221 ttaccgttgt atatttaatg gggatggtgg gataaacatg gtcgataaaa aaagcagagg 1445281 gcatatcaat agcgaccttg aatttaagaa aaaaaagcat gcccgggaga tgaaatatca 1445341 agtcctgtct tttggtttaa tgatcggtct tacgattgtt gcatttctga ctgtggccac 1445401 ggacggtgtc ggcagctggt ttacgattcc tttcattatt ttgctagctg caattcaagt 1445461 catttttcag ctgtattatt tcatgcatat gaatcagaaa gggcatgagg cgccggcact 1445521 gtttttgtat tcaggggtgt ttgtcgcgtt tatcactgtg cttgcgtttg tgacaattat 1445581 atggtggtaa tttgaacagc cgccggaggt gaagaaatga atcagttgga gatatttggg 1445641 tttcgcgcga tgtggagccc ttatcttttt tgtatcctgt taggcattac ggcgctttat 1445701 ctctattttt acaggcgaat gtcttcaaag ccgaatcgaa taactggtaa agagatggtg 1445761 tgctttctgt cggcgatgct gtttttatat gcagccgagg gaagcccggt tgatctgctc 1445821 ggacatatta tgttcagtgc gcatatggtg cagatggccg tcctgtattt ggttgtcccg 1445881 ccgctgttaa tcgcggggat tcctgcatgg ctctgggaaa aaatcatttt caggccttca 1445941 atcaaaccgg ttttttcctt ttttacgacg cctttaattg ctttgctttt gtttaacggc 1446001 attttttctt tatatcatgt accgcttata tttgatactg tcaaaacaga tccgttttac 1446061 catacattaa tcacttggct tatctttgtg cttgcgttct tcatgtggtg gccgcttgtt 1446121 cataaggttg agcgtctacg gcagctcagc ggcttgatga agctgggtta tattatggcg 1446181 gacggtatgc tgctcacacc tgcttgcgcc ttgatcatgt tcagcggtgc accgttatac 1446241 gccacctata cagatccggc tttatgggct gaggcaatga ggctttgcgt gccagcggat 1446301 atgatggggc aggtcccatt aacagggcca gagatgttga atacactgcc tttgttagag 1446361 gatcagcagc tcggagcagt catgatgaaa atcattcagg aaattgtgta cggtactttt 1446421 ttggccgtta tttttttcca atgggtgaag aaagaaaggg aaaaggacgg gcaggaggag 1446481 ccgccgtata ttcagcagac gatatcataa aaggtacagc gaaatatgct gtaccttttc 1446541 gttacatttg aactgttttt aacatgttgg ctatgtcctg aatcagtgcc ttgctttttg 1446601 tcacaacctg tacgggaaac tcttccgttt ctccatattc tactccatga gggtagtaat 1446661 gctttcctag gagaggggac attaattgaa tcacggcgcg cccgcttccg acatcgcctt 1446721 ctgccgcaat accttgtatc cgcaggtaaa acgtaccctc aatcgtcgaa aacttcttgt 1446781 cataggtgac tctctcgtaa tcccattgac ccgctctgat aagacctttg ctttccatta 1446841 agtcgtctag ccagctgagc tcagccttaa ccccttcaag tccgctttca gtaaacttca 1446901 acactgaccc ctccttataa aaattacctt tcctgacaat catagtatga aagcgttaaa 1446961 ctttcaatga atcttcttct tttgaaagta tgcaaaaatt aaattttgac gacaatagca 1447021 ctagactaaa ggaggttaaa cggatgacaa aaataaaaga tctgatgaca gccgacttgc 1447081 aatattgcac ggtattagat aatgtatatg aagctgcagt aaagatgaag gacgcaaatg 1447141 taggagcgat accggtagtt gatgaggacg gggaaacatt ggtcggcatc gtaaccgacc 1447201 gcgatctcgt attaagagga atcgccatca aaaaaccgaa ctcgcaaaaa atcactgacg 1447261 cgatgactga aaaacctgtc agtgtggagg aagatgcttc agtcgatgag gttcttcatt 1447321 tgatggcatc gcatcagctc agaaggatac cagttacaaa aaataaaaaa ctgactggaa 1447381 ttgtcacgct tggtgatctt tctttatctg agcaaacgaa tgaacgtgcc ggcagcgcct 1447441 tatcggatat ttccgaaggg gataatagag aagaaggctt ttttcattaa cacataaatc 1447501 tttgacatgt taaataggct gtattgtaat gggatgtaaa caagagattg tgaatcgcca 1447561 cgggggtgat agattgaaaa atatattgag agcaatggtt atccttttga ttatctgcgg 1447621 aacctatgtt ctgtttattc aatatggatc tgttcctgaa aagaaatcaa atgacagcga 1447681 gcctcaggtg tcgaatgagg aagcgcaaag cggcaaacga atacatatgc cgacttcagg 1447741 gttattgtcc ttcatgggca agcacgccga tgaagtaacg aaaaagcttg gggaacctga 1447801 acgtattgac ccttcggctt atgattacga ttggtgggta tacaatcaag gtaaggatca 1447861 atatatccaa atcggggtat taaacaataa agtggtcaca ttattcgcgt cgggtaatga 1447921 tattaacgcc aagcctttca aaattggaga atcaactggc gaagtattca agaccaccca 1447981 ggtggcacca tttgtgaatg tagagtataa aggaaattcc tatcggtttg aattttctga 1448041 agaagatatc aatacaagac cgactgtaaa ggtaggaaag atgtatgtcc agctgtatat 1448101 ggacaaattt gaggggaagc tatccagcat cagggcgttt gatgcgcaga cctttgtaaa 1448161 gcaaagacct tatgaggtag tgtaccgcgg ggaattaatt aaaccgaaag ccgtttcaga 1448221 tgagaaatgg aaaaagatcc aaacaacgag cgaaaagcaa atccttgatt tgacgaatgt 1448281 catacgcgtt aaacatggac ttgcgaagct tgagtgggat cagccaacgg cggaagtggc 1448341 atttgggcat agtgaggata tgaaggaaaa taattatttc tcccatgtct ctaaaaaata 1448401 cggctcgctg aaagaccgct tagaagaagg gcatgttgat tttcagcaag cgggagaaaa 1448461 tatcgcatac aattatgtgg acggtccggc tgctgtagaa ggctggctga atagcgaagg 1448521 ccatcgaaaa gcgcttctga attcagatta tacgcatctt ggtgtcggag tagaccggaa 1448581 atattacacc caaaacttta ttaagcgatg gtaatgaaag ccgcggacga atggttcccg 1448641 gctttttcta tttccataca agctggtctg aatgaatgtg ctgatagctt acagataagg 1448701 ccgtttccca tcccttcagt caggcttttt caccagtgta tagggatatc gctaaaaatt 1448761 catttgggaa tgaatatagg cgaacacaat gcccgacaaa acgatacatt gtagtaggta 1448821 acgattttcg gagggggtga ggattgtggc gaatcaacat gccaatcatt caatcaatga 1448881 ctttaaacaa ttcgtcaaaa agcatcccaa gctgataaaa gaagtgcgca aagaacaaag 1448941 aagctggcag gacgtatatg aaaattgggt cctcttcggg gagagcgacc cgatttggga 1449001 tccatatcgg gaaccggaag aagcttctga agctgtgcct gaaacaccgc aaaaaaatga 1449061 ttttgtctcg aaaatggtga cagcggtgaa aaagatggat gtcaatcaaa tgaacgaaca 1449121 aatcaataaa atgagccagt cgatctcatc gttgcaaagc cttcttaata cattttccgg 1449181 aagcggacag aagcattctc agccaggctc tggacagcat cctttttctt ttcgaaagga 1449241 ttaaaaaagg ggagctcata tgcgcaaaga ggttcaggaa tatattttag caaacgaaga 1449301 acggaaacga ttcatcagag aacagccgat atggtaccgc aggctttcaa gaaaaccgga 1449361 tgatctgtcc tcctttcagc ttgaaatgat gaatttttat gaaaaaacca ttccgcatcg 1449421 ggtgaatcag tttacgaacg ggattcaaat ggcgcaaatg atgatgcaaa tgtttcaagc 1449481 gatgcggaca aaagattaaa aggccccgaa gaagggtctt ttttcatgcg gtcataaggt 1449541 tttgttggcg gctgcggtta agcattttcc aattggctgg tttcatggta aactaacaac 1449601 tggaggtgca tgttatgtat gcgacgatgg aatccgtgcg gcttcaaagt gaagctcagc 1449661 agcttgccga gatgattctg cagtcggaga cggctgagaa ctaccgcaat tgttacaagc 1449721 gtctccagga agatgaagag gcaggtcgga ttattcgttc ttttatcaaa ataaaagagc 1449781 agtatgagga tgtacagcgt tttggcaaat atcatcctga ctatagagaa atatcccgga 1449841 aaatgaggga gatcaaacgt gagctggacc tgaacgataa ggtggctgac ttcaagagag 1449901 ctgaaaatga gctccagtcc attcttgatg aggtcagcgt tgagattggg acagctgttt 1449961 cggagcatgt gaaagttccg actgggaacc cttattttga cggtttgtct tcatgcggag 1450021 gcggctgcgg ttcaggcgga agctgcggat gtaaagtgtc ctgacgagac tggccgtctc 1450081 gtcttttaca tataagagaa aacaggcagg tgattgtatt ggagaatagg cgccagggca 1450141 tggttgtgta tctgcactcc ctaaagcaga gcaaaatgct gaggaagttc gggaatgtgc 1450201 actatgtatc aaaacgatta aaatatgtcg tactgtactg tgatatggac caaattgaaa 1450261 aaacaatgga caagattgcg tcttactcat ttgtgaaaaa agtggagcct tcttataaac 1450321 cgtttttaaa attggaattc gagtcaaagc ttgataaggc aaaagaatac gattataaaa 1450381 tcggcatata gctataaaaa aatccccgca ggcatctgcg gggtccttct attccttaat 1450441 atgttaagga gaaggcaaag ggagaggaga aaccggagga agaacttatg gggaaacgta 1450501 agtcttctcc gcggttggca acaacatcct ctagatgctg ttgcttatag tatggacaag 1450561 gatcatgctg cctatacacc tgtttatcaa gattagcgtt cattgtttgg aagaatgctt 1450621 tatgttaaga taggattgat ttttttctat gtacatagcg gcgtccggcc gaataaagaa 1450681 acaaaatagc ttttagaaaa agtggtgtgg aacatgagag taatttctgg atcaaaaaaa 1450741 ggccgttcac taaaggctgt agccggaaca tcaacaagac cgacaaccga caaagtgaag 1450801 gaatccattt tcaatatgat cggcccttat tttgacgggg gcaggggact tgacttattc 1450861 gcagggagcg gaggtcttgg aatcgaagcg ctttcacgcg ggtttgagca ttgtatattc 1450921 gttgaccgtg attttaaagc gattcaaacg gtaaaatcta atttgaaaac gctggagctt 1450981 acaaaacatg cacaggtata ccgcaatgat gcggaacgtg ctttgcacgc tgctgctaaa 1451041 agagaaaccg gctttcgcgg aatttttctc gatccgccgt ataaggaaca aaagctgaaa 1451101 gcacttttaa ctttgattga cgaatatcaa atgctggaag aagacggctt tatcgtcgct 1451161 gagcatgaca gagaggtcga gcttcccgaa accgtaggag atcttgtgat gacaagaaaa 1451221 gaaacctatg ggttaacagg tgtagcgatt tataaaaaga gggggtagtg aggtggcgag 1451281 tatagctgtc tgtcccggca gttttgatcc tgtgacctac gggcatctgg acatcatcaa 1451341 acgcggggcg catatttttg aacaagtgta tgtatgtgtg ctgaataatt cttcaaaaaa 1451401 gcctttgttc agtgtggaag aacggtgtga gcttctgaga gaagtcacaa aagacattcc 1451461 gaacataaca gttgaaacat cgcaaggcct gttaattgat tatgcaaaaa gaaaaaatgc 1451521 gaaagcgatt ttaagaggct tgagagctgt atctgatttt gaatacgaga tgcaggggac 1451581 atcagtaaac cgggtgcttg atgaatctat tgagacgttt tttatgatga caaacaatca 1451641 atattcgttt ctaagttcaa gcatcgtaaa agaagtggca agatacaacg gctcggtatc 1451701 agagtttgta ccgccggaag tagagttggc gcttcagcaa aaattcagac aaggatgagg 1451761 gttttgactc atcctttttt tgttccgttt gtcagtctgt aagaaaaaat gataatgtac 1451821 gtaaacagcg cgcatagtgt gacagcaggt ccgatctgca caagcagatt ccagccgttt 1451881 ataaaggcag ttgacatgtc actgctgtta agagatttaa atacatactg atacggatca 1451941 tgccatgctg tgtaaagagg tttccataaa agcatgacga agacagcggc ataaacgccc 1452001 tgcagcaaac gtgcgataaa gaatggttta aatctaatgt cggtttccga taaaatacct 1452061 gccacctgag cttgtacgga aaagccgcta aacccaagaa taaagctgac gataatggct 1452121 ttttgcagaa gagaaacatc tgtctcgctg acaagcttgc tgcctaatgt aatttcaaac 1452181 atccctgata aaagcggaat gtccaattga gtcggaagct gaaacaaagt cagtgctcct 1452241 tttgtgaaaa cagacaaaac atcagtcagc tggaccactg acaacagccg attgaagaca 1452301 gaaaataaaa taataaagcc gcctaccata agaagcgttt gaacagaaga cgtcacggcg 1452361 tcgcctaaaa ttttacctaa gggccgtttt tctgcaagtc tggcggtatg aagagcgtgt 1452421 aaagcatctt tgactgaagg gaaaggtatc gttttctttc ttctgagatg ctgctcttcc 1452481 ttgcggccat aggagcgcat tgttaaaccg acggcaagat tccccaaata gtgtgcagaa 1452541 gctaataaaa tgcctagtga tgcgttttga aagaaaccga cggcaacagc gccgaaaata 1452601 aagagcgggt ttgaagaatt ggtaaacgac gcgagccgtt ctgcctctac tcttgaaatc 1452661 tgattttcct gccgcagacg ggcagtgagt tttgcgcccg ctgggtttcc tgatgccatt 1452721 cccatagcaa gaacgaagcc gccgacaccc ggcacgcgaa agatcggccg cataaaaggc 1452781 tcaagcaaaa caccgacaaa ccgcacaatg ccaaagccga ttaagagttc ggacagaata 1452841 aaaaatggca gcaatgacgg aaacacaacc tcccaccaca tagacagccc ggttttagag 1452901 gcttcgaatg aggcctgtgg atgtgagatg acagtcgctg ttaaaaaaag aaaaaacgag 1452961 gcaatcaaaa gtgtattaat cttcgacaag ttcattctta cctccccgat gctaaaaatg 1453021 cccaatgaca tgtatatcat gataaaataa tgtatgatgt aaaacggcca agcagtacct 1453081 gtcctcttga ttctttgtac taatatacga gcataggggt tcagtttaga ccatagaatt 1453141 cggtatacag ggaattcagg caggaggtta acgctttggc caaacctaaa atcgggttag 1453201 cgttaggatc gggaggggcc agagggcttg ctcatctcgg tgtgctttcc agtttacata 1453261 agcaccaaat tgaagtggat atgattgcag gaagcagcat gggcgctttg gtgggcagtt 1453321 tttacgccgc cggacatgac gtggcaacga tgaaaaaagt agccaaagcc tttaaacgaa 1453381 ggctttatgc tgattatacg gtgccgaaac tcggtttttt aaaaggtgac cgcgtcagac 1453441 agcttgtgca tgcttataca ttcggaaaac cgattgaaga gctccaaatc ccgctgggca 1453501 ttgttgcgtg tgatctacag acgggagaaa agattgtgtt ccgaaaagga tcagtgtcag 1453561 atgcagtgag ggccagcatc agcatcccgg gtatctttat tccgcagcgg ctggacggac 1453621 gccttcttgt agacggcgcg gtcgtcgatc gaattccggt ttctgttgtg aaagacatgg 1453681 gagctgatat tatcatcgct tcggatgttt ccagggttcg aaaaactgaa acagcagtgc 1453741 atatttttga tgtgattatg caaagtatgg atatactgca aaatgaatta gtgcggcatc 1453801 aaacaattgc cgcagatatc atgattcgcc cttcccttga aacatacagc tcaagctcgt 1453861 ttgccaatat tgaagaaatg atatcggcag gcgaagaggc gacaaaccga atgatcagca 1453921 agataagaaa agaaatagag aattgggagg gctcataatt tgctacgtaa aaaacatttt 1453981 agctggatgc tcgtcatcct catactgatc gccgttttat catttataaa acttccatac 1454041 tatattacaa aaccgggaga agcgacagag cttgcttcat tgataaaagt ggagggaggc 1454101 tacccggaaa aaggaagtct gtccttaatg actgttaaag tgggaccggc taatccattt 1454161 acatatgtgt gggcaaagat gcacccttat tatgaaattg ttcctgatga gagcattaag 1454221 gaggaaggcg aatcagataa ggagtatatg aaaagacagc tccaaatgat gaaaagctcg 1454281 caagaaaatg cggttatagc cgcctatcaa aaggcaggaa aaaaagtcag ctattccttt 1454341 aacggcatat acgcaagctc agttgtagaa aacatgccgg caaaagggaa aatagaagtc 1454401 ggtgataaaa tcatcagcgc agacggcaaa aactatcagt ctgctgaaaa gctgattgat 1454461 tatatcagca gcaaaaaagc gggagataaa gtcacgttaa agatcgaaag agaagaaaaa 1454521 gaaaagcgtg tcacccttac gttaaaacaa tttcctgatg agccggatcg ggcaggaatc 1454581 ggagtttcgc tttatacaga cagaaacgtg aaggtagagc ctgatattga ttttgaaatc 1454641 gaaaatattg gcggcccgtc agcagggtta atgatgtccc ttgaaatcta taatcagctg 1454701 acaaaaccag acgaaacaaa aggctacgat attgcgggaa caggtacgat tgatgttgac 1454761 ggaaaagtag gcccgatcgg cggcattgat caaaaagtcg tcgccgcaga caaagccgga 1454821 aaagacattt tcttcgcgcc aaatcaaaac ggcgccagca attccgatta taagaacgca 1454881 gtaaaaacag caaaagatat tgattcaaat atgaagattg tgcctgttga taccatgcag 1454941 gatgcgattg attatttgaa taagctgaaa gcgaaaagca cctgattctc aggtgctttt 1455001 tctatacatt taaaaagtgt tgttcatctt cgtcatatcg aatcggtgca tgtccgtatt 1455061 cctgtaggtc aaactcagtt ctcagcggct cttctatcgg caggctgtaa atcctgcttg 1455121 cttttacgtc cagatcgaga gctggatggg agaaagagga cagtttgctg acaagcggaa 1455181 cagacagtgc ttttttcttt tcggataaat aagcctgtcc ttttttcgtc atgccgagaa 1455241 gcctgatata cggcgcctta tcgttgtcaa gcagcttttg catatcctgt ttttttgttc 1455301 tggttaaaat gtgtgtattc atccgctgga gccttgtcca cgtatagcgt tttgttttca 1455361 gcagttccat aaattcctga taggagctgg attttctgat cgaacgaata attctgtgct 1455421 ctaaaccttc ctccacctcg tatacttgct gtaattcccg tgccgttaca gttgaaaggc 1455481 tgtattttaa gtaagaaaag tagctttcag gtgtatgcca caatccgaaa gatttgcggt 1455541 aagctgctaa ttcacgtgca gatgcagcag ggagaaaacg aaggcaggct tcgagattct 1455601 ggccaatcat cgcttttcta atgcttgtgg cacttgctat atggttttcg ccttcaggga 1455661 gatcggcatc atgatagtcc gaagagattc gtgccgtagt ataaggtttc ataggatatc 1455721 ccccggttag aatcgaggtc acatactggt atcccaaaat gttatttggt tttgacaagt 1455781 caagtgcact ttcagtatgc aaaatggagc tgaaggcgat agccgccgct gctgggtaac 1455841 tggccccctt tttaagttct tctttaattc ggtcattcaa tatatgttta tgctcatcaa 1455901 taagctgtgc tgtttctaaa aaaggcttga tatccccatt ttcactcccg aaaaacagcg 1455961 cctcacattc aagttcgttc aggatggaaa cactgccgcg tgcaaaaatg tctgcttttt 1456021 gcacggcata aagataaggc agctcaatga caagatcaac tccgctttgc agcgccattt 1456081 ttgttcgggc ccattttgat acaacagcgg gttccccgcg ctgtaaaaaa tgtccgctca 1456141 tgaccgcgac agccgtgtca catccggttt gcagctttgc tgtttgggca tgataaaggt 1456201 gaccgttatg aaagggatta tattcaacca ccaatccgac agctttcata ttttttccgc 1456261 ctttcttgct atgtttaaaa acgtatggta catttgcaaa tgaaaactct tacgccttat 1456321 ttttgtttta agtgtatgca tagcatattc cgctgtcaac gatacttcaa tggcagcatt 1456381 atgctgtaaa gaaaaaatat tgacaaaaac aatcttaaaa gctataatca tgtttgttgc 1456441 tttcctgagg tgatacaaat gaaatggacg atttatcagc tgcatcaaat gccaaaacaa 1456501 agttttgagt ttgatgaaac agttgagtta aatgagctga caaagctgaa ttctgacatt 1456561 cgccgcattt ctcccgttcg ggtgaagggc agagcggata tcaaatccaa acaggtttcg 1456621 tttgatttta caatttcagg cgaaatgctt ttgccatgct caagaacact cgttgatgtt 1456681 ccgtatccat ttgaaatttc aacaaaagaa ctgtttatat ttcatcacac ggatgatata 1456741 gaagatgatg acgttcacat tgttgaggac gatactatcg acataactcc gatcgtgaaa 1456801 gaagaaattc ttttagaaat ccctatgcaa atcttttgtg aatctgaaca agaaaaagga 1456861 gctgctcctc aagaaggaaa ggattggcaa gtcatttcgg aagaagacaa gaagaatcaa 1456921 gttgatccga gacttgcagc ccttgaaaag ctcttaaaac aagatgatga atcttaactc 1456981 tttaaggagg tgggaataat ggctgtacct tttagaagaa cttctaaaat gaagaaaaga 1457041 ttgcgccgta cacatttcaa acttaatgta cctggtatga cagaatgtcc gtcatgcgga 1457101 gagatgaagt tgtctcaccg tgtatgcaaa gcatgcggat catacaacgg caaagacata 1457161 aatgtaaaaa gtaactaatg agaaaagcgc agggtgaaag ccctgcgctt tttctttttc 1457221 tcttcctgtc agcttgcgga aaatttgtga gtgcaaatag tctatctaat ctattaccgg 1457281 catatgtatg agataaataa gctgacatgg agggagattg aatttgacca ttacaagaca 1457341 agatgcttgg actcaggatg aggatttgct gctggcagaa gtggtgcttc gtcatattcg 1457401 agagggagga acacagcttt cagcctttga ggaggttgga agggcgctga ccagaaccgc 1457461 ggcagcctgt ggtttcaggt ggaactcgta tgtgagaaaa caataccagt caggtataga 1457521 gcttgcaaaa aagcaaagga aagaactgag aaagcaaatc ggcgttcatt cggtcaatat 1457581 gccgaattcc atgaagcaga ctgcctcggc atcgtcagaa ggaaaacgag atttgtccat 1457641 tcaggatgtc attcaatttc tcgaacaatt caaagaaaca ccgtctgcac aagaatttca 1457701 gcttgaaagg gaaaaattga aggagcaaat ccaatcgctg caaaaagagc ttgaggattt 1457761 gcggagtgaa aatcagacat tgcggaatca gctagagatg acagaagagg attacaaggc 1457821 actgatcgat atcatggatc gggccagaaa aatggttgtt tcgaaggaag acggaagaat 1457881 gaaaaaagcg gctcaagaaa cgtaaagaaa cgcctgaaat gaaccggccc tatagtaaga 1457941 ataggccggt tgttttgatt tctatgcaga ctctcccggt gtcatttcgc gatccatatc 1458001 aggatgccag atgagcgggt tttccccttt gtcccgcgcc atatcatact taacagtttt 1458061 aaagttcatt ttgttccaaa attccgctga tttcattctc ggatttgtcc ggatcggcat 1458121 tttgaatgat tttgcaaatt caaccaaggc tctcccgtat cccctgttct ggtagcccgg 1458181 aagaacctca agcttccaca gctccaaata atcctggcgg ttgtcaaaat agggattcga 1458241 tttgccgtta acttgataca gactcattcg tgctacaagt ttatcgccaa aataaatccc 1458301 gtaaaaaggc gaggtgctgt cattttcaat aatattatcc tgaagttctt caagcattga 1458361 aagctcctga atgccgtatt ctttgaattt cttgaattct tccagcgttt tatagttgat 1458421 aagcagacgt tctacctttg tcaaacaaat ctcccccttt gttgtttcta catatattgt 1458481 aaacgcttta tttaaaaaat ccaaatattt aaactttaat tttaagcaca tgggatcttt 1458541 gagaagtaat ttcttcttac ttctgctatg ataatacgta aatgctaaat tgggtgtgac 1458601 atcatgaaaa ttggaattat cggcggaggc tccgttggtc ttttatgcgc ctattatttg 1458661 tcactttatc acgacgtgac tgttgtgacg aggcggcaag aacaggctgc ggccattcag 1458721 tctgaaggaa tccggcttta taaaggcggg gaggaattca gggctgattg cagtgcggac 1458781 acgagtatca attcggactt tgacctgctt gtcgtgacag tgaagcagca tcagcttcaa 1458841 tctgtttttt cgtcgcttga acgaatcggg aagacgaata tattattttt gcaaaacggc 1458901 atggggcata tccacgacct aaaagactgg cacgttggcc attccattta tgttggaatc 1458961 gttgagcacg gagctgtaag aaaatcggat acagctgttg atcatacagg cctaggtgcg 1459021 ataaaatgga gcgcgttcga cgatgctgaa ccagaccggc tgaacatctt gtttcagcat 1459081 aaccattcgg attttccgat ttattatgag acggattggt accgtctgct gacgggcaag 1459141 ctgattgtaa atgcgtgtat taatccttta actgcgttat tgcaagtgaa aaatggagaa 1459201 ctgctgacaa cgccagctta tctggctttt atgaagctgg tatttcagga ggcatgccgc 1459261 attttaaaac ttgaaaatga agaaaaggct tgggagcggg ttcaggccgt ttgtgggcaa 1459321 acgaaagaga atcgttcatc aatgctggtt gacgtcattg gaggccggca gacggaagct 1459381 gacgccatta tcggatactt attgaaggaa gcaagtcttc aaggtcttga tgccgtccac 1459441 ctagagtttt tatatggcag catcaaagca ttggagcgaa atacaaacaa agtcttttga 1459501 gctttttcgg taacatgcta tactcatttc ggatcactaa ctatttattg gagaaaggaa 1459561 gttctagaag atgcagctaa ctgaactttc catcaaaaat cagaatgtgt ttgtacagca 1459621 ctatatagat ggcaaagaag aaatgtcttc tttttttgat tacagtattc atcataagga 1459681 catgtggcgc gaaagactgg aagacttatc ttcccggttt ttcgcaagag aggaattggc 1459741 ggcgtactta acctcttacc ataataaatt cggttcaagt gcgatgcagt ctgctattga 1459801 gaagctgaag gacccgtcaa gtgccgctgt agtcggcgga cagcaggcag gacttttaac 1459861 aggaccgctt tacaccatac ataaaatcat ttcaatcatt gttttagcaa agcaacaaga 1459921 aaaggaactg caagtgcctg tcataccaat cttctgggtg gctggagaag accacgattt 1459981 ggatgagatt aattttgttc acacatctga agagaatggg cctgtgaaaa aaaagctgcc 1460041 tcagtcttat tggaagaaat catcagcagc gagtacatcg cttgatcagg aaaagtgtgc 1460101 cgcgtggata gatgatgttt ttgccgcttt tgaagaaaca gaccatacga atacacttct 1460161 cgacaatgtg aaacgatgtt taagggaatc tgttacgttt actgacttct ttgaactgct 1460221 gatcgcggat ttgttccaag aagagggctt agttttatta aattctgggg atccggggat 1460281 taaaaagctg gaaacggcca tgttccaaaa gattcttcga gaaaatgatg aactcgcccg 1460341 ggctgtatca gatcagcagg ccttcatgcg tcaagcaggc tacaaaccga ttatcgagtc 1460401 cggaaaagag caggcgaatc tgttttatga atacgaagat gagcgttttt taattgaaaa 1460461 agataacggc cgatttgtca tcaaagagct tgatctagga tggacgaggg atgaacttca 1460521 tacacatatg gaagaacatc cagagcgttt cagcaacaat gttgtaacga gaccgttaat 1460581 gcaggaattt ctcattccga ctttagcatt tattgcaggg cctggggaaa tcaattattg 1460641 gggcgagctc aaacaggcat ttgcggtgat gggcttcaaa atgcctcctg tcatgccaag 1460701 gctgaacatt acgatacttg agcggcatat tgagaaaaaa ctggctgaac ggaatatctc 1460761 attacaagac gcgattgagc gcggaacgga gaatcaaaga gagacatact tcgagcgcca 1460821 gattccggaa gagtttacgg cggtgatgga tcaggcgaaa agccaaattg aagcgattca 1460881 caaaacggtc cggcaggagg cgttaaaggt tgatcaaagc ttggaacctt tacttctgaa 1460941 aaatgccgct tttattcagg atcagcttca attcttagag cgcacggtga tgaagcgaat 1461001 tgaagaaaaa gaaggctacg tcttgaagga ttatgaaaga attcaaaata gcattaagcc 1461061 gcttcttgcg ccgcaagaac ggatttggaa tatcatgtat tatttgaaca ggtacggtcc 1461121 aaaattcttc acgacattca agaatctgcc attttctttt caaaatcaac atcaagttgt 1461181 caaactttga aataaagttt taaagaaccc tgactagttc agggtttttt tttatgggta 1461241 aacagtgtaa aatgaagttg tggagcgaag tggtgaatag tggtgagtta aggagagaaa 1461301 gtggggcaag agatcatgtt tatgggtgaa tatcagcata ccatcgatgc gaaaggccgc 1461361 atgatcgtac ccgctaaatt cagagaaggc ctaggtgagc aatttgtgct gactagagga 1461421 cttgaccaat gtctcttcgg ctaccctatg cacgaatgga aacaaattga agaaaaacta 1461481 aaagctcttc ctctcacaaa gaaagatgcc cgcgcgttta cccgtttctt cttttcaggg 1461541 gcgactgaat gcgaactgga taagcaaggc agggtaaata tcgcatcatc tctattgaat 1461601 tacgccaaac tggaaaaaga atgtgttgtt atcggggttt ctaatcgaat tgaattgtgg 1461661 agtaaagtaa tttgggaaca atacacagaa gagcaagaag attcatttgc tgaaattgct 1461721 gaaaacatga ttgggtttga tatataatga ttcttcgtgt ataacactct aaaaacaatt 1461781 tcaattcatc ctgataaaag gtgggaccaa cacaatatgt ttcaacacaa gacagtactt 1461841 cttcgtgaaa ccgtagacgg acttaatatt aaaccagacg gtacatatgt agactgcaca 1461901 ctcggcggag ctgggcatag tacatactta ttgcagcagt tatccgagaa ggggcgttta 1461961 atcgcttttg accaagatga tacggcatta cagcatgcta aagaagtgtt gtccgattat 1462021 aaaggacagc tcattctgat taaaagcaat ttcaggtatt taaaagaata tttgaatgaa 1462081 caaggcgtta cagaagtaga cggcatttta tttgatttag gggtgtcctc tccgcagctg 1462141 gatacaccgg agcgcggatt cagttaccat catgacgcac cgttggacat gaggatggac 1462201 cagtcggcta cgctttcggc gaaagaagtc gttaatgagt ggcgctatga ggatctcgtc 1462261 cgtattttct ttaaatacgg agaagagaag ttcagtaaac agatcgccag aaaaattgag 1462321 gaggcaagaa tgaagtctcc tattcaaact acgggccaac tggtcgatct aataaaagac 1462381 gcgattcccg ctccagcgag aaggagcggg ggacatcccg ctaaacgcgt gtttcaggca 1462441 atcagaattg ccgtaaacga tgaacttagg gtgtttgaag aagctttgga gcaggcaatt 1462501 gaggttctga agccaggggg cagggtatcg gtcattacct tccactcgct agaagacaga 1462561 atttgcaaaa ccacttttaa agaaaagtcg tcgcttccgg aacttcctcc gggacttcct 1462621 gttataccgg aagagtttga accggagctg aagctcatca cacgaaaacc gattacggca 1462681 tctcaagaag agcttgaaga gaacaaccgg gctcgttctg ccaagcttcg gattgctgaa 1462741 aaaagaaaat aacgaaacgc gaacgcaaaa ttaaaaggag gtcatcagcc tatgagcaat 1462801 ttagcttacc aaccagagaa acagcagcgg catgcgatca gtcctgagaa aaaagtgatt 1462861 gtcaagaaaa gggcttccat tactctcgga gaaaaagtgc ttcttgtcct ctttgctgcg 1462921 gcggtgctca gcgtatcgct tttgatcgta tcgaaggcgt atgcggcata tcaaaccaat 1462981 attgaggtgc aaaagcttga ggagcaaatt tcatccgaaa ataagcaaat tggtgacctc 1463041 gaaaaaagcg ttgctgattt aagcaaaccg cagcgcatta tggacattgc gaaaaagaac 1463101 ggcttgaatt taaaagataa aaaagtgaaa aacatacagg aatgattcaa atgccaaaaa 1463161 agaataaatt tatgaataga ggagcagcga ttctaagtat ttgtttcgct ctctttttct 1463221 ttgtcatcct ggggagaatg gcatatattc aaataaccgg aaaagcgaac ggcgaagtgc 1463281 ttgcgacaaa agcgacagag cagcatgaaa agaaacggac catcgaagcg agccgcggct 1463341 cgattttaga ccgaaaagga aaagtcattg cagaggacac agcgacgtat aaactgattg 1463401 cgattctcga taaaaaaatg accactgatg tcaagcatcc tcagcatgtt gtaaacaaag 1463461 aaaaaacggc ggaagcattg tctaaagtga taaacttgga caaggccgac atccttgata 1463521 tcttaaataa agatgcaaaa caagtcgagt ttggctcagc tggccgggat attacgtatt 1463581 cacaaaagca aaaaatcgaa aaaatgaaac tcccgggcat ttcattttta cgggatacaa 1463641 aacgctacta tccaaacgga gtatttgcat ctaatctaat cggctatgcc gaggttgatg 1463701 aagaaacaaa tgaaatttcc ggcgcgatgg gattagaaaa agtgctggat aagtatttga 1463761 aggagcggga cggatatgtg acatatgaaa gcgacaaatc cggctgggag ctcccgaaca 1463821 gcaaaaataa aattacagcg ccaaaaaatg gtgacaatgt atatttaacc attgaccaga 1463881 aaattcaaac ctttttggaa gacagcatga caaaagtggc gcaaaagtat aatccgaaaa 1463941 aaatcatggc cgcagtcgtt gatccgaaaa cgggcaaagt ccttgccatg ggacagcgcc 1464001 caagctttga tccgaacaag cgcgatgtga caaactacta taatgatttg atttcatatg 1464061 cgtatgaacc cgggtccacg atgaagatct ttacactcgc tgctgcgatg caggaaaacg 1464121 tgtttaatgc gaacgaaaaa tataaatcag ggacatttga agttggcgga gcacctgtta 1464181 aggatcacaa taacggtgta ggctggggtc cgacaacata tcatgacggc gtcctaaggt 1464241 cgtcgaatgt cgcttttgcg aaactggcga aagaaaagct gggatatgac cgcctcaatc 1464301 aatatttgca caaattcaat ttttaccaga aaacaggtat tgatttgcca ggagaagtct 1464361 ccagcaaaat caactttaaa tatgaatttg ataaggcgtc aactgcatat ggccaagcgt 1464421 ctgcggtcac accaattcag cagattcagg ccgcaacggc aattgcaaat gacggtaaaa 1464481 tgatgaaacc ttatgtcatt gaccatatcg ttgaccctga taaagataaa actatttatc 1464541 aaaataagcc ggaatcagcc ggaactccaa tttctgcaag tactgcgaaa aaggtgcggg 1464601 atatattagg agaagtcgtt acatcgaaga tcggaacagg gcaagcttat aaaatcgaag 1464661 gttttgatgt tgccgggaaa acaggtactg cgcaaatagc cggtaaaggc ggatatttag 1464721 acggcacaga taactatatc ttttcgttta tgggtatggc gccaaaagat gatcctgagc 1464781 ttttaattta tgttgctgta cagcagccgc aactaaaagc aggacaaagc agttcagatc 1464841 cagtatcaga aatcttcaat ccaacaatga aaaatagcct gcactaccta aacatcgaac 1464901 caactgaaaa atctgactca gataaggaag aaacaaaagc gcagacaatg cctgatttaa 1464961 cagatcaaac ggtagctgct gctcaaaaga aagcaaaaga ggagaatctc acaccaattg 1465021 tcatcggcag tgatgtcgct gtaaaagaac agtatccgaa agcggatgag gaagttctca 1465081 ccaatcaaaa ggtcttcctg aaaacgggcg gcaaaatcaa aatgcctgat atgacaggct 1465141 ggtcgagaag agaggttctg cagtacggcg agctcgcggg aattcatatt gaagtaagcg 1465201 gacaaggcta cgctgtcagc caaagtgtta agaaagacaa agaaatcaaa gacaaaaccg 1465261 taatcaaggt taagtttaaa aatcctgatt aaaaagaaag ccgtcgttat gcaggctttc 1465321 tttttttatg ccttcagagg agcatcgttc tacctgtcca aattcaggca taaaatgaaa 1465381 caagcctaaa taaggagtga acggtctctt gcgcgtctcg aatgtaacgg ttagaaaacg 1465441 tttattattt gttttgcttt ttggcgtgat cgtgtttctg atcattgata caaggctggg 1465501 gtatgttcag tttgtgatgg gcgaaaaact gacttcgcta gcgaaagatt cctggagccg 1465561 gaacttgccg tttgagccgg agagaggcga gattctggat cggaatggtg tgaagctcgc 1465621 aacaaataaa agtgcgccga ccgtattcgt cgtgccgcgc caagttcaga atccgatgaa 1465681 aacgagcaag cagcttgcgg cggtgctcaa tatgtcagaa gaaaaagtat ataaacatgt 1465741 gacaaaaaaa gcgtcaatcg aaaagatcac tcctgaaggg agaaaaattt caaatgagaa 1465801 ggcgaaagaa atcaaagcgc ttgatttaaa aggtgtgtat gttgcggagg acagtatccg 1465861 tcattacccg ttcggcagct ttttatctca tgtgcttgga tttgcaggaa ttgacaacca 1465921 agggctcctt ggacttgaag cctattacga cgatgattta aaaggggaaa aaggttctgt 1465981 taagttttat acagatgcca aggggaagaa gatgcctgat gaagcggatg actatacgcc 1466041 gcctaaggat gggcttgata tgaagctgac agttgattca aaggttcaga cgataatgga 1466101 aagagagctt gataacgctg aggccaaata tcatccggac ggcatgattg ccgtagccat 1466161 gaatccgaaa aacggagaaa ttttggggat gtctagcagg cctgacttcg accctgctga 1466221 ttaccaatct gttgatccgt ccgtctacaa tcgaaatctg ccagtatgga gcacgtatga 1466281 accgggatct acctttaaaa ttattacact tgcagcagcc cttgaagagc aaaaagtaaa 1466341 tttgaaacgg gatcaatttt atgataaagg gcatgctgaa gtggacggag cgagactgcg 1466401 gtgctggaaa agaggcgggc acgggctgca gacgtatctg gaagttgtgc agaactcctg 1466461 caacccgggg tttgttgaat taggcgagcg cttaggaaag gaaaagcttt tcaaatatat 1466521 caaagacttt ggttttggac aaaaaacggg gattgatctc caaggcgagg gaacaggcat 1466581 cttattcccg cttgagagag tgggcccggt ggagcaagca actacggctt tcggacaggg 1466641 agtatccgtc acgccgattc agcaggttgc agcagtatcc gccgctgtaa acggaggaac 1466701 gctctataca ccttatattg caaaggaatg gatcgatcct gttacgaaga aaacggtcaa 1466761 aaaacaatca ccaatcgcaa agaaacaagt catttctgag gaaacatcca aacaaatccg 1466821 ctatgctcta gaaagcgtcg tcgcagaagg aaccggccgc aatgcatttg tagaaggata 1466881 tcgtgtcgga ggaaaaacgg gaactgcaca aaaggttaaa gatggaaaat atcttgaaaa 1466941 caaccatatt gtatcattta tcggtttcgc gccagcagat gatccgagtc tagtcgtcta 1467001 cgttgcggtg gataacccga aaggcacgat tcagtttggc ggaacggtgg cagcgcctat 1467061 tgtcggaaat attatgagag acagtctgcc ggaacttggt gtgaagcccc ggaaaaatca 1467121 aatcgagaaa aaataccaat ggaacgacac aaaaacaata gaagttccga atgttgtagg 1467181 gatgtctgtc tcagatcttg agtcactatt ggtgaatctc aatgtggatg cttccgggaa 1467241 agggagcaaa atcgttaaac aatcgccagc tgccggaacg aaagtaaaag aaggctcaaa 1467301 gatacgcgtg tatttgactg aagaagatga aaaggaggca gccgattgat tcgggctgcc 1467361 tattctttta ttgcagaaaa aatgctgata tctttcaaga ttagctggat gtatcctttt 1467421 atttacgcta aaatatgaac tgtatgctta aaatcattac cacatcattt gatgtgactt 1467481 caatgataaa aagaacgaat tagaatgttg agaggtttga tacgatgaaa cttacaaagc 1467541 tgcttacata cttaacaacc gaaccttctg taaacgactc acaagaccct gaaataactt 1467601 caattgagat ggactccagg gaagtaaaga aagggagtct ttttgtatgt gtaaaagggt 1467661 atacggtgga tggccacgat tttgcgcaaa aagcagtaga aaacggtgca gcggctattg 1467721 tggcagaaag agaggtcgat gtgaatgttc ctgttattat tgtccggcag tcacttcgcg 1467781 cgctcagcgt tttgtctgat gcgttttacg gacagccgac gaagaagctt cagctgattg 1467841 ggataacagg gacaaacggc aaaacatcaa cgacccacat ggtcgatgag attctgaaaa 1467901 aagcgggaaa acgcacaggc ttgatcggta caatgtacat gaaaatcgga gacgaaacac 1467961 ttcctgttaa aaacacgact ccggaaagcg tcacgctgca gaaaacgttt aagaaaatga 1468021 atgacaagca cgttgacact gcaatcatgg aggtttcttc ccacgctttg tctttaggac 1468081 gcgtccatgg ctgtgattat gatattgccg tgtttacgaa tttaacacag gaccatctgg 1468141 actatcataa aacgatggat gagtaccggc atgcaaaaag cttgctcttt tcccaacttg 1468201 gcggggcttt caaccatgaa catccaaagc gtgccgtcct gaatgctgac gatgaggcga 1468261 gcgcttattt tgaaaaggta acagctgcgc atatctctac atacggaatt aaaaacgatg 1468321 ctgatgtgat ggcgaagaac atcagtatca ctgcacaggg cacaagcttt gatctcgtga 1468381 caaacaaagg cacgaagcac atcacgatgt ctctcgtcgg acaatttaat gtgtataacg 1468441 tgctggccgc tgttgcgaca tgtattgcag caggcatacc gtttgaaatc atcactgagg 1468501 ctgttgaaga attgcatggt gtaagaggcc gttttgaatt ggtcaatcag cagcaggagt 1468561 ttcctgtcat tgtagactac gcgcacacac cggacagcct tgaaaatgtg ctggagacat 1468621 gcagagacat gacggaagga aagctatttg tcgttgtcgg ctgcggagga gacagagata 1468681 agacgaagcg cccgaaaatg gctaaaattg ctgtggagct ggctgacgag ccgattttca 1468741 cgtcagataa cccgagaagc gaagatcctc gcgcgatttt aagagatatg gaagccggag 1468801 tagagaacgc atactatcac agtattgcaa accgcgagca ggcgatcttt ttcgcaattg 1468861 ccaatgccaa aaaaggcgac gttgtcctca ttgccggaaa aggacatgaa acctatcagc 1468921 agatcggaaa tgaaactttc gattttgatg atgctgaagt agcggcgaga gccattgttg 1468981 aactcaataa gaataagacg aattcatagg aaagagatgt tactgaataa tggagcttga 1469041 aaagattttt catatggaaa aaaatcatga atatgataac tacgtatgtc gtttgaaaga 1469101 aacaggagga gaaaaggaca atgcttgagc aagtcattct gtttacaatt ttaatggggt 1469161 ttttaattag tgttctgctc tctccgattc ttattccgtt tttaagaaga ttaaaattcg 1469221 gccagagtat tagagaagaa ggaccgaaat cacatcagaa aaaatcaggg acaccgacaa 1469281 tgggcggggt catgatcata ctttctatca tagtgacaac aattgttatg acacagaagt 1469341 tttcagaaat aagccccgaa atggtgctgc ttctgtttgt tacgctaggc tacggtttgc 1469401 ttggcttttt agatgattac atcaaggttg tcatgaagcg caatcttgga ttgacatcaa 1469461 agcaaaagct gatcggacaa attattattg cggttgtatt ttacgccgtg tatcattact 1469521 acaattttgc gacggatatt cgcattcctg gaactgactt atcatttgat cttggctggg 1469581 cttactttat ccttgtgctc tttatgctag tcggcggatc aaacgcagtt aacctgactg 1469641 acggccttga cgggttatta tccggtactg cggcgattgc ctttggcgcc tttgccattc 1469701 tggcatggaa tcagtctcaa tatgacgtag cgattttctc agttgccgtt gtcggtgcag 1469761 ttctgggctt ccttgtattt aatgctcatc cggccaaagt ttttatggga gatacgggat 1469821 cgcttgcatt gggaggagcc atcgttacca ttgccatttt aacgaaatta gagatcctgc 1469881 tggttatcat cggcggtgta ttcgttatcg agacattatc cgttattttg caggtcatca 1469941 gctttaaaac gacaggtaaa cgaatcttta aaatgagtcc gcttcatcac cattatgagc 1470001 ttgtcggctg gtctgaatgg agagtagtcg tgacgttttg ggctgcggga cttttgcttg 1470061 ccgttttagg aatttacatc gaggtgtggt tataagtgga aaatgatcaa tttttacaga 1470121 aacagcattt tttaatcctt gggcttgcga aaagcggata tgcggcggcc tccattcttc 1470181 atgaaaaagg catttatgtt gcagtcaatg atcaaaagcc ttttgaagaa aatgaaccgg 1470241 cacaaaagct ttctgaaaaa ggaatcgaag ttgtttgcgg agagcatcca gtttctctgt 1470301 tcgatcagca tcaaatcacg attctgatca aaaacccggg aattccttat gaaaatatca 1470361 tggttcagga agcagagaaa cgaggtattc cggtttggac ggaaattgag ctcgcttact 1470421 acctgaccag cgccaagttt atcgggatta ccggatcgaa cggtaaaacg accacgacaa 1470481 cgctaattta cgaaatgctc aaggctgact cgcaaaaagc actgattgcc ggaaacatcg 1470541 gcacagtcgc aagtgaggtt gcctatcatg ctgatggaga tgaatggatc gttaccgaac 1470601 tgtcttcgtt tcagctgatg ggaacacacg ctttcagacc ggaaatcagc ctgattttaa 1470661 atgtatttga cgcccatctg gattatcacc atacgcgcga aaactatgaa aaagcgaaac 1470721 agaaagtgta ccttcatcag actgcttcag ataaagctat tgtcaaccag gatgatgaaa 1470781 ccgtcgtgcg tcttgctgaa gccggaaaag ccgaaatcgt cccattttca gtcagcaaaa 1470841 cgcttgaaca gggcgcatat gtaaaagaca gtatgattat gtttaacggc gaagccattc 1470901 ttcctctgga agaggttgta ctgcccggtg ctcataacct ggagaacatt ttagcagcta 1470961 ttgcagttgt gaaaacggca ggagcatcca atgaggcggt taaaaaggtg ctgacaagct 1471021 ttactggtgt gaagcaccgc ctccaatatg tcacaactgt gaatggccgc aaattttata 1471081 acgacagtaa agcaacaaac attctggcga caagcaaggc gctttcagct tttgataagc 1471141 cggtcattct gcttgcgggc ggactggatc gcggaaatgg ttttgatgac ttgaaacctt 1471201 atatgaagca tgtcaaagca gtgcttacat ttggccagac ggcgccaaaa ctcgagaaac 1471261 tcggcaatga actgggaata caacatgtca aacgtgtcga taatgttgaa caagcagtat 1471321 ctgcggcgtt tgcgctctca aatgaaggag atgtcatcct gctgtcaccc gcgtgtgcga 1471381 gctgggatca attcaaaaca tttgaagaac gcggtgacat gtttatagat gccgtgcata 1471441 tgcttaagta agggcttgtc ttgaagtaaa tcggcagccc taatgacttt aagcttgggg 1471501 tgtcgattgc tttgactact aaaaaaacat cgcctgattt gttattggtc atcattacgt 1471561 tattattatt aacaatcgga ttaattatgg tgtacagtgc gagtgcggta tgggcggatt 1471621 ataaatttga cgactcattc tttttcgcga aacggcagct tttgtttgcg ggaatcggcg 1471681 tcattgctat gttttttatc atgaatgttg attattggac ttggaggaca tggtccaaat 1471741 tgctgatggt tatctgcttt ttccttctgg tgcttgtttt gataccgggc gtcggaatgg 1471801 tgcggaacgg ttcaagaagc tggatcggag tcggagcatt cagcatacag ccttcagagt 1471861 ttatgaagct tgcgatgatt gcattccttg ctaaatttct ctctgaaaaa caaaaaaaca 1471921 tcacatcgtt cagacggggg ttcgtccctg cacttggcat cgtgttttca gcatttttga 1471981 ttatcatgtg ccagcctgac ctcggaacgg ggacagttat ggtcggaact tgtattgtca 1472041 tgatttttgt agccggcgca cggatcgccc atttcgtctt tctcgggctg atcggcctca 1472101 gcggatttgt cgggctcgta ctatcggctc catatcggat aaagcggatt acctcatact 1472161 taaatccatg ggaagacccg ctcggaagcg gatttcagat cattcaatcg ctttatgcag 1472221 tggggcccgg cgggttgttc ggaatggggc tcggacaaag cagacagaag ttcttttatc 1472281 tgcctgagcc gcaaacagac tttattttcg ccatcttgtc agaggagctg ggctttatcg 1472341 ggggaacact tattttgctc ctcttcagcg tcctgctgtg gagaggaatc agaattgcgc 1472401 ttggtgcgcc tgatctgtac ggaagctttg tcgcagtcgg cattatttca atgattgcca 1472461 ttcaagtcat gataaatatc ggcgtagtca cgggcctgat tcctgtaaca ggcatcacgc 1472521 tcccgtttct gagctacgga ggctcttcat tgactctaat gctgatggca gttggtgtgc 1472581 tgctgaatgt aagccgctac tcgaggtatt aacgaatgta tttccaagcc tcctgtctaa 1472641 catgaagctt ggaaacaatt gatgcgataa ccctgtccaa caaaacaggg ttatcgttat 1472701 gttatagaga aacttagact gggggaaaaa agaaatgcga attgcaataa gcggaggcgg 1472761 tacaggggga catatttatc ctgctcttgc ttttattaaa gaagtgcaaa gacgtcatcc 1472821 taatgtggaa tttttatata tcggaacaga aaacgggctg gagaaaaaaa ttgttgagcg 1472881 ggagaatata ccgtttcgtt caattgaaat tacaggattt aaaagaaaat tgtcatttga 1472941 aaatgtcaag actgtgatgc gttttctgaa gggcgtcaaa aagagtaaat cgtatttagc 1473001 ggaatttaag cccgatgccg taattggaac gggcggttat gtatgtgggc cggttgtcta 1473061 tgccgctgcg aaaatgggaa ttccgactat tgtccacgaa caaaacagcc tgccgggcat 1473121 cacgaataag tttctttcaa aatatgttaa taaagtagcg atttgttttg aagaagcgaa 1473181 atcacatttt cctagcgaga aagttgtatt tacgggaaac ccgagagcct ctgaagtcgt 1473241 ctcaataaag acgggacgat cattggctga atttgggctt tctgaagaca aaaaaacggt 1473301 cttaattttc ggcggaagcc gaggcgctgc accgattaac cgcgctgtca ttgacatgca 1473361 ggatgtgctg aaaacaagag actatcaagt gctgtatatc accggtgaag ttcactatga 1473421 aaaagtaatg aatgagctga aaagcaaggg tgccgctgat aatatggtca caaagccgtt 1473481 tcttcatcaa atgcctgagt atttaaaggc cattgatgtc attgtggcca gagccggtgc 1473541 gacaacgatt gccgaaatta ctgctctcgg aatcccaagt gttctgatcc caagtccata 1473601 tgtgacagcg aatcaccagg aggtcaatgc gaggtctctt ggccagcatg atgcggcgat 1473661 tgtactgaaa gaaacagagc tcagcgggga gaagctgatt gaagcgctag accggattgt 1473721 actgaatgag caaacgttaa aggaaatgag cgaacgaaca aagtcactcg gtgttcctga 1473781 cgcggctgcc cgtttataca gcgtactcga ggaattaaaa aaatagtaga aaagcaaatg 1473841 gaatgcggag gtttacgatg gagaaagtga tacaggaatt aaaagaacga gaagtcggca 1473901 aggttcttgc aaatgaaccg ctcgcgaatc atacaacgat gaaaatcggc ggacctgcgg 1473961 atgtattggt cattccaagc agtgtggatg ctgttaaaga catcatggac gtgattaaaa 1474021 aatatgatgt gaagtggaca gtcatcggcc gcggatcaaa tcttcttgtt ttagatgaag 1474081 gaattagagg cgtagtgatc aagctggggg cgggtcttga ccatttggag cttgaagggg 1474141 aacaagtaac agtcggaggc ggttattcgg tggtccgcct tgctacatca ttgagcaaaa 1474201 aaggcctgtc cggtttggaa tttgctgccg gcattccagg atcagtcggc ggagcggttt 1474261 atatgaatgc cggcgctcac ggttctgata tgagcgagat cctcgtcaaa gcgcatattt 1474321 tatttgaaga cggaacgatt gagtggctga caaatgagca gatggatttc agctacagga 1474381 catctgtact gcaaaagaaa cgcccgggcg tttgccttga agctgttttg cagcttgagc 1474441 agaaggataa ggaatcaatc gttcagcaaa tgcaaagcaa taaagactat agaaaaaata 1474501 cacagccgta ttcaagccct tgtgcgggaa gcatattcag aaatccgctt ccgaatcatg 1474561 ccgggaacct tgtagaaaaa gcaggcttga aaggatatca aatcggcggt gcaaagatat 1474621 cggagatgca cggaaacttc atcgtcaatg cggggggagc atcagcaaaa gatgtgcttg 1474681 atctcattga ccatgtgaaa aagacaatcc gtgaaaaata cgagattgat atgcacacag 1474741 aggttgaaat catcggcgga aatcgctgat tcaagttctg actgaagctg ttcatatgat 1474801 atactgtaag caaacgacaa acggcatcat agtatgccgt ttgttttgga atagacagac 1474861 ttttaacagc tgtttcattt gaatgaggtg aacaggcaat gaacccgggt caagaccgag 1474921 aaaaaatcgt taacattgaa gagcggatcc ctaaaattaa agagcagagg aaacaaaagg 1474981 caaaccgccg tctcatttca tttattatgc tcttttttat tatggtgctg atcattgtgt 1475041 acctgcaaac accaatcagt aaagtatcaa caatctctgt tacagggaat gaaaatgtat 1475101 caaaaaagga aattatcgac ctttccgata ttaacagcgg agatactgag ttttggagtt 1475161 tggacaagca aaaaacagaa aagaagattc agcaaaataa attagtgaaa aaagcggaga 1475221 tcagcaaatc gcttcctaat aaaatcaaca ttgcaatcga agaatataaa gcgattgctt 1475281 atttagaaaa agacgatgtg tactatgaag tgcttgaaaa cggctcagtt ctgccaaacg 1475341 aagtaacgcc ggatgatgcc ggaccgattt tagtgaattg gacaaacgcg aagaagcggt 1475401 ctcaaatggc caagcagctc gatgcgttgt caaattcgtt aaaacagtcg atttcagaaa 1475461 tttattatac gcctgtaaaa atggatgaaa accgtattaa gttgtacatg aacgacggtt 1475521 atgttgttac ggcatctatt aaaacgtttg cagaccgaat gaagacgtat ccttctatca 1475581 tctcacagct aagcagcaat aaaaaaggaa tcattcattt agaagttgcc acctattttg 1475641 aagagtttgg gaaaaacgat aaagctgcta aaaaggaaga tgaaaattga ggggcaaatc 1475701 agcagtcctt ctttccttga ttatgcttat cgcaggtttt ttgatttcat tttcttttca 1475761 aatgacaaaa gaaaacaaca aaagcgcggc tgagacggaa gagtggaaaa aagaatatgc 1475821 gctgagagat gaactgctga aacaagagaa agaaaataag aagtttgaaa aagaattata 1475881 tcaaaagcaa aacaaagtcc gccaggcgga aaataagctg aagaaagaga agtcggaata 1475941 ctataatgtc ctcgaagata cagaaaaata caggatgtat attggggaag tcggtgtgca 1476001 gggagaaggc gttgaggtga cattggaaga tgcgtcatac ataccggaag gggagaatgt 1476061 gaatagttac atcgttcacg aaagccatat cttccaagta gtaaacgaac tgtatatctc 1476121 aggagcggca gctgtcgccg ttaatggaca gcgtttgacg catgattcgt atatcaaatg 1476181 caatggtcct gtggtaacgg tagacggggt gcagcatccc gctccgttta cggtatccgc 1476241 tattggagat ccagatgtcc tgctgccctc gttaaatatc gctggaggcc taattgatca 1476301 gctgtcaatg gatcatattt ctgtgtcggc agaaaaagag aaaaacgtac aaatgaaacc 1476361 gattctgaaa acgaaggaat gactgaaaaa gcgggtgaaa tagattgaaa ataaagcgtt 1476421 ccttcataag catcagtgtt cttatggtca tcttcggcct gatgatatct gttcagttta 1476481 attcgttaaa gcaccccaaa gtccgggata caagagatat gtgggatatt agggaagagc 1476541 tgacatcaga gcagaagaag caggaaaagc tgctggctga aataaacaaa tatgacaaat 1476601 tgctgaatag ctattcgcaa acgaaagaaa tgacaaaaga aaccgcgcta aataatacct 1476661 tgcaatcctt aaaaaaaaca gccggcatga ccgatataac aggtagcgga attgtcatta 1476721 cgatttcccc gcttttttct gaaagcttaa caggagagcc gatcgaaaat ccgcctccgg 1476781 atttgctgaa aaagctgata aatgaactca actcctacgg tgcagagcat atctcgatta 1476841 atgagcgaag agttgtgaat catacagtca tcagagatat aaacggcact acaaaaatag 1476901 acggatacgc ccttgacgat tatcctttaa cagtaaaagt gcttgccaaa gatccggaca 1476961 tgttacacag cagagtgaag gggtcaggcc ttgaggatct ttttgcatct gaaaatttag 1477021 cattaaaagc cggtaaatct gaaagcaaac taacattaaa agcatatgac agaccactgg 1477081 acgtacaaca gctgaaactg cttaaagact gaaaaggagg agaattgtca tgtggctgcc 1477141 cgtgttggga ctggtgctcg gaatagcgat tggactaatg acaaacttaa cgataccgag 1477201 tgaatactca aactatttat cgcttgcggt gcttgccgca cttgatacat taatcggcgg 1477261 aatcagggcg catttacaag gtacatatga tgaaatggta tttgtttccg gtttcttttt 1477321 taatattata ttggcaataa gtttagcttt tctgggagtc catcttggtg tagacttgta 1477381 tttagcaggt atattcgcat ttggagtcag attatttcag aatatagccg ttatcagaag 1477441 aaatctacta acaaagtgga ctctttctaa aaaaaataaa aaaaatgtga tataaaagag 1477501 gatatacata ggatataacg aatattttca ataaacataa aatgtgaaaa gcacataaaa 1477561 atattctgtt gttatttttt gttacacact tgtaaagcca cattcattgt attgttgttc 1477621 cgcaaataat agaatagaaa tgatcgaaat gtgaggaggt gccatagaat gaacaacaat 1477681 gaactttacg tcagtcttga catcggtacg tccaatacaa aagtgatcgt cggagaaatg 1477741 acagatgatt cccttaatat tatcggtgtg ggaaatgtac cgtctgaagg gttgaaaaaa 1477801 ggctcaatcg ttgatataga tgagaccgtt cattctataa gaaaagcgtt tgaccaagct 1477861 gaaagaatgg taggttttcc gcttagaaaa gctattgtcg gcgttaatgg aaattatatc 1477921 aatattcaag atacaaacgg tgttgtagca gtttccagtg aaaataaaga aattcaggtt 1477981 gaagatgtac gccgtgtcat ggaggcggca caggttgttt ccgtaccgca tgaacagctg 1478041 attgttgacg tcattcctaa acagtttatc gtagatggaa gagatgaaat caccgacccg 1478101 aaaaaaatgc tgggtgtgcg tttagaagta gagggcacct tgatcaccgg ttcaaaaaca 1478161 atcttacata acttactccg ctgcgttgaa agagctggta ttgaaataac tgatatttgc 1478221 cttcagccgc tggcagccgg ttctgctgca ttatcaaagg acgagaaaaa ccttggtgtg 1478281 gctctcattg atataggggg agggtcaaca accattgccg tattccagaa cggacatctc 1478341 acttctaccc gtgtcattcc tctcggaggc gaaaatatca ccaaagatat ctccatcgga 1478401 ttgagaacgt caacagaaga agcagaacgc gtgaaaaagc aacttggaca tgcctactat 1478461 gacgaagcct cggaagatga aatatttgag gtaaccgtta taggcaccaa tcaaaaacaa 1478521 acatttacac agcaagaagc agcgaatatc attgaagcga gagtagagga aattcttgaa 1478581 attgtttcag aagagcttcg cagtatggga attaccgatc tgccgggagg cttcgtgctg 1478641 acaggaggac aagcagctat gccgggtgtc atgtctttgg cacaggatgt gctgcaaaac 1478701 aatgtcagag tggcaagccc gaattatatc ggtgtaagag atcctcaata tatgacggga 1478761 gtgggcctga tccaattcgc ctgccggaat gcaagaatcc aaggcagaaa aataggcttt 1478821 aagatgcctg aagaagcgat acaggaaatc gcagtctcat catctgagga acaagagcag 1478881 catcatcacc aaaatgaggt gcagcagcgg ccaaaaggaa aacaaaaaac acaagccgaa 1478941 cataataaac agagcaaaat gaaaaaacta ttaagcatgt tttgggaata gatagatagt 1479001 cattcggcag attaggagga tttagcatgt tggagttcga aacaaacata gacggcttag 1479061 catcaattaa agtaatcgga gtaggaggcg gcggtaacaa cgccgttaac cgaatgattg 1479121 aaaatgaagt gcaaggagta gagtatatcg cggtaaacac ggacgctcaa gctcttaacc 1479181 tgtcaaaagc agaagtgaaa atgcaaatcg gcgcaaagct gactagagga ttgggagcag 1479241 gtgcgaatcc ggaagtcggg aaaaaagccg ctgaagaaag caaagagcag attgaagaag 1479301 cacttaaagg tgctgacatg gtattcgtga cagctggtat gggcggcgga acaggaacag 1479361 gtgccgcacc ggttatcgca caaatcgcga aagacttagg cgcattaaca gtcggcgttg 1479421 tgacaagacc gtttaccttc gaaggacgca aaagacagct tcaggctgca ggcggaatct 1479481 cggcaatgaa agaagcggtg gatacactga tcgtgatccc gaacgaccgt atccttgaaa 1479541 ttgttgataa aaacacaccg atgcttgaag cattccgcga agcggataac gtacttcgcc 1479601 aaggggttca aggtatttct gacttgattg ctacacctgg tcttatcaac cttgactttg 1479661 ctgatgtgaa aacaatcatg tcaaacaaag gatctgcttt gatgggtatc ggtattgcta 1479721 ctggggaaaa tcgcgcggca gaggcagcaa aaaaagcaat ttccagcccg cttcttgaag 1479781 cggccattga cggtgcgcaa ggcgtcctca tgaacatcac tggaggaaca aacctcagcc 1479841 tatatgaggt tcaggaagca gcagacattg tcgcttcggc gtctgatcaa gacgtaaaca 1479901 tgattttcgg ttctgttatt aatgaaaatc taaaagatga gattgtggtg acagtgattg 1479961 caaccggctt tatcgaacaa gagaaggacg tgacgaagcc tcagcgtcca agcttaaatc 1480021 aaagcatcaa aacacacaat caaagtgttc cgaagcgtga gccaaaacgt gaggaacctc 1480081 agcagcagaa cacagtaagc cgtcatactt cacagccggc tgatgatacg cttgacatcc 1480141 cgacattctt aagaaaccgt aataaacgcg gctaatgtaa aggacaaaat cgttttcgat 1480201 tttgtccttt tttgtttttc tcttcacact ttccttctta taaagtcttt ttccctattg 1480261 cttccttcgc gagctcgatt atggatggtt tacgttttgg aaaaagtaag gtatcctagt 1480321 tcgtacaaag ttttatgaaa attaaaacaa ttataaaagg caataaagag gaggaccacg 1480381 atgattttgc agcttgacaa tgtctcacta aaacggaatg ggaaatggat actgaaagat 1480441 attcattgga aggtggaaga aaaggaaaat tgggtgcttt acggcctaaa tggcgccggg 1480501 aagacagcgc tgttaaatat gctttgctca tattattttc caacatcagg cgagatgcag 1480561 gtgctcggcc atgaatttgg caaaacagag cttggggaaa agctcagacg taaaattggc 1480621 ctcgtctcag cagctcttca gcaaaaattg tatccggcag attcagcttt tgaaattgct 1480681 ttgagcggag cttacgcttc gattgggtta tatgaaacgc caagtaagga aaccagggaa 1480741 aaagcgatag gtttgttaga ggacttggga gcaattgaat atgccgatcg ccgctatgaa 1480801 accctttctc aaggggaaaa acaaagagca ttgattgcta gagcactaat ggccgatccg 1480861 gagctgctga tactggatga accagtcaca ggactggatt ttattgcccg ggaaaagctg 1480921 ttagatacga ttacatacat tgcaaacaaa gaaaatgcac catctatcct ttatgtgact 1480981 catcatgctg aagaaatttt gcctgtcttt gataaagccc ttttattaaa acagggagag 1481041 gtttttggat ccggagaaat aaaggaaatg cttactgatc aaatactttc cgcttttttt 1481101 gatacgccaa tccatgtatt atggaatcag gatcggccgt ttttaacaag agctgagccg 1481161 ataacgaatg cctgacaaat atatatagat tcatcctagg ggtgctttgc gaagctgaga 1481221 gagactttgt ctcaaccctt ttgacctgat ctggatcatg ccagcggagg gaagcggtga 1481281 aaagcggagt acatcggact ccgtttgttt ttattaagcc gtttcatcac atttgaaacg 1481341 gcttttttga ttttaaagaa taggagcgga tttacattgg atcaacaaat atactctttg 1481401 caaaaaaaag tggaagaaca taaggaggag cttattcagc ttgcgaaaac gctgatttct 1481461 tatcaaacac ctgctccgcc tgcaagaaat acagagggca ttcagtcttg gattgcggga 1481521 tatttaaatg aattgggatt ctcgatcgac aaatgggatg tgtaccctgg agatcccaat 1481581 gttgtaggga agctaaaagg aacagattca gcagattatt atagcctgat tatcaatggc 1481641 catgtagatg tggcagaggt aaaagaggat gaagaatgga agcacgatcc gtttcatccc 1481701 attgaaaaaa acggtctctt aatcgggcga ggcgcttccg atatgaaggg cggaatggct 1481761 tgtgtgctgt ttgctgtcaa attaattcgt gaagcaagca ttgaacttcc aggtgatctg 1481821 attctgcaat cggttattgg ggaggaagtt ggagaggccg gcacacttga atgctgcaag 1481881 aggggctacc acgctgattt tgcaattgtc gcggatacga gcgatatgca tattcaaggc 1481941 caaggcggtg tcattacagg ctggatcgaa atcaaaagca gtcaaacatt tcatgatgga 1482001 acgagacgga atatgattca tgcaggcgga ggaacattcg gagcaagcgc aattgaaaaa 1482061 atggcaaaaa tcattgcggg gctcggtgaa cttgagcgcc actggtctat tatgaaaagt 1482121 tatcccggtt ttaaaccagg cacaaatacg attaacccgg cagttataga aggcggcaga 1482181 catgcggctt ttatagcgga cgaatgccgg ctgtggatca cagtccattt ttatccgaat 1482241 gaaacccatg accaagtggc agcggaaata gaagattacg tcaatcggct gagtgacagt 1482301 gatatttggc ttagggaaaa ccgccctgta ttcaagtggg gaggctcatc tatgatagaa 1482361 gacaggggag aaatttttcc ggcattggaa gttgaccctg gccacccagg cgtcttagcg 1482421 ctaactgcct ctcatcagaa agtgaaacgg gagtgtccaa ttattgacgt ttctcaatca 1482481 gttacagatg gcggatggct gtatgatgcc ggtattccat gcgtaatata cggtcctgga 1482541 gatctgcaca atgcacactc tgtgaacgag aaggtatcga ttgagcagct agtagagtat 1482601 acaaaaatta tactcgattt tatcatcagc tggtgcagcc ggaaaaaaga acaatgacat 1482661 gaaaatttct tcttgctgac aaggttcagc ctgcccgttc atatacttga acaaaaggac 1482721 ggaaaaagga cgtgatggaa tgatcagcat ttcagaattt caggtaaagg atgtcgtcaa 1482781 tgtctcaaac ggaaaaaagc tggggagtat tggtgatatt gatatcaatg tgaccactgg 1482841 aaaaattcag gcgatcatac tcggaggaaa tgggaaagtt ctcggatttt ttggaaaaga 1482901 agaggaattg gtcattccat ggcgaaatat agtaaaaatc ggggaagatg taatcttagt 1482961 ccgattaagt gaaccacatg cataaacctg cttgtctgcc gcagattggc aaatgccgga 1483021 agtctcgatt cttccggcac atttcattta gaaatatgca aatcggcgct caacgaatgc 1483081 agtaagatgt ggtaaaataa gtgggaaatt ccgctttttt aaatgtttgt cgaaaggttg 1483141 gatcatcatg aatacatatc acccattcag tcttaccaca ccctcgacac tcatgataca 1483201 agactgggct caaacgaatc aaaacaacaa agaggtcatt gccggattta cgacaaaaaa 1483261 cggcggtgtc agccaaaagc cttttgaatc gttaaataca ggattgcacg ttcatgacaa 1483321 agatgcagat gtagttaaaa atcgtgaata tattgccgat atgtttaata ctgatttgca 1483381 gtcttgggta ttcgctgatc agacacatga taatcgcgtt cagaaagtga cgcagaggga 1483441 taggggaaaa ggcgcccgtg agtatcacac ggctctaaaa gcaacggacg ggatctatac 1483501 aaatgaaaaa aatgtatttt tagcattatg ctttgctgat tgtgtgcctc ttttctttta 1483561 tgatccggtt aagtcgcttg tcggagtcgc ccatgccggg tggaaaggca ccgtcaaaca 1483621 gattggcaga gaaatggtga agcaatggac tgagaaggaa ggttcaaatc cctcagatat 1483681 ttacgctgtt attggcccgt ctatcagcgg agcatgctat acggtagacg accgcgtcat 1483741 ggatgctgtc cgcgcattgc cggtttcagc agaccttgcc gccaatcaga cggcaaaggc 1483801 acaatatcag cttgatctga aagagctgaa ccgtcttata ctgatggaca gcggtttggc 1483861 aagtgaacaa atttctgtca gcggtttatg cacggaaagc gagccgtctc ttttctattc 1483921 tcatcgccgc gatcagggga aaactggacg gatgatgtcc tttatcggaa tgaaggaggc 1483981 ataaaagatc ttgcgtgttg ttgataattt acgacatata aacgaacgaa taaacgaagc 1484041 atgtaacaga tcgggccgca gctccgatga agttacggtt attgcagtca caaaatatgt 1484101 atcacctgaa agagcacagg aggcagtaga tgctggcatc acctgcctcg gagagaatcg 1484161 ggatgcggaa ctgctccgca aacaggaatt gatgaaaggg aatccggaat ggcattttat 1484221 cggcagtctg caatcaagaa aagcaaaatc tgtcgtcaat tcggtttcct atatccattc 1484281 cctagaccgg ctctcattag cgaaagaaat tgaaaaacgg gctgaaggta ctgtacgatg 1484341 ctttgtgcag gtcaatacct ctcttgagcc ttctaaacat ggcatgaaaa aagaagaagt 1484401 cattccattc atacaggagc tttccggttt cgaacatatc cttgttgccg ggctgatgac 1484461 aatggctccg ctgactgatg atcaagatca gatcagaagc tgtttcaggt cgctgagaga 1484521 actccgtgac caggttcaga agctgaacca gccgaacgct ccgtgtactg aactgtcgat 1484581 gggcatgtca aatgattttg aaattgcaat tgaagaagga gctacttata ttagaatcgg 1484641 ctcatcgtta gtcggaaatg aaacaggggg tgtacagcaa tgagtatgaa aaataaactg 1484701 aaaaactttt tctcaatgga agatgaagaa tacgaatatg aatatattga gacagagcgg 1484761 gaatctcatg aggagcatga gcaaaaagaa aagccggctt acaacgggaa taaacctgcg 1484821 ggcaaacaga atgtagtgag cttgcaaagt gttcagaaat cctctaaagt ggtgttgagt 1484881 gagccgcgcg tttatgcgga ggcgcaggaa atagccgacc atttgaagaa ccggcgggca 1484941 gttgtcgtca atcttcagcg gatacagcat gaccaggcga agcggattgt tgacttttta 1485001 agcggaaccg tttatgccat tggcggcgat attcaaagaa tcggctcaga tattttcctc 1485061 tgcacgcctg acaacgtaga tgtatcaggc acaatttctg agctcatatc tgaagacgaa 1485121 catcagaggt ggtaaagcga gatgatcctt tatcaagttt tttcggtttt aagcttatta 1485181 atcacaatat actcatttgc cctgatcata tatattttta tgtcatgggt gccgagtacg 1485241 agggaaacag cagtcgggcg ttttttggct tcgatttgtg aaccatatct cgaaccattc 1485301 agaaaaatca tccctccgat tgcaatgctg gatatttcac caatcgtagc aatacttgtg 1485361 cttcggtttg cgacaaccgg cttgtgggga ctttatcgca tgattgcgtt ttaatgtgac 1485421 agtttgatag gggcttggca gcagccaagc ctctttacat agaagggaaa gacgatgagc 1485481 gatatatatc agcacttcag aaaagacgag cgggccttta ttgatcaagc gctcgaatgg 1485541 aaaagaattg tccaggagca gtaccggatg aagctgaccg actttttaga tccccgagag 1485601 caggtcatcc tctctgctgt tacgggacag gcagatgtcg ggcttgcctt ttccggcggc 1485661 tatgacagag cggagcggaa acgggcgatt ctgtttccag agtacattac tccggaagaa 1485721 tcagattttg aactgcaggc gtttaacgtc cgttatgctg acaagtttgt ctcagtagat 1485781 catcgttctc tgcttggtgc attaatgggc ataggattaa agcggcaaaa attcggtgac 1485841 atcgtgtttt ctgagacagc agtgcaattg attgtctcag ccgataccgc tgattttgtg 1485901 gctgcacagc tgacccaagc aggcaaagcg gcggtcagcc tagagaaaat cgacttgtca 1485961 gaccttaaca ttccagcagt tgatgtcgaa ataagagatg acacggtttc ttctttaagg 1486021 cttgacgccg tctgcgcctc tatgagcagg caatcccgcc agaaatcaca gacgcttgtg 1486081 aaaaacggcc ttgtgaaagt gaactggaag gtggttgaag atccttcata catagtcgcg 1486141 gaaggggaca tgctgtctat cagaggtttt ggccggtgca gcttaacaaa aatcgaagga 1486201 aaaaccaaaa aagacaaatg gagagttacg tttgaacgac aaaaatagtc ggtttttcag 1486261 tttttttctc catctgtgcg aaatttgttt tataatgtga actagataac cgtactgaaa 1486321 tgtaaaaatg gaggtggcat catgccatta acgccaaatg atattcacaa caagacgttt 1486381 acaaaaagtt ttcgcggata tgatgaagat gaagtaaatg aattcctagc ccaagtcaga 1486441 aaagattacg aaattgttct ccgcaagaaa actgagcttg aagcgaaagt caatgagctt 1486501 gatgaaagaa tcggacactt tgccaatatt gaggagacat tgaataaatc aattttagtt 1486561 gctcaagaag cggctgaaga cgtaaaacgc aattctcaaa aagaagcaaa gctgatcgtt 1486621 cgggaagcgg agaaaaacgc tgatcgcatt atcaacgaat cgttatcaaa atcaagaaaa 1486681 attgcaatgg aaattgaaga gctgaaaaaa cagtctaaag tgttcagaac acgtttccaa 1486741 atgctgattg aagctcagct tgatcttctg aaaaatgacg attgggatca tctccttgag 1486801 tatgaagtcg acgctgtatt tgaggaaaag gaataaattc tctgattatc ttgacatttt 1486861 cttagcttgt cgaatataat acgttcataa attcagatga aaaaacggtt gaaagggaca 1486921 gtcatgtttc cttcaggcct tcatagcgac ccggagatgg tgagagtccg ggatggccgg 1486981 aatcatgtag atcagccctt tagtttcctt gctgaactca cagtaggtta ggacgttcat 1487041 cacgttacga tgctcaagag gaaaaagtgt atgcttgctt tttctaaaag ggtggtaccg 1487101 cgagataagc tttctcgtcc cttatgggat gagagggctt tttttatttt ctgaaaaaat 1487161 gcagtggagg aatgaaaatg gattttaaag acacgctctt aatgccgaaa acagatttcc 1487221 cgatgcgtgg aaatttgcca aaccgtgagc ctgacattca aaaaaaatgg gaggaagaag 1487281 atatctaccg tcttgttcag gaacggacga aagaccgccc gaaatttgtt ttacatgacg 1487341 gacctccgta tgcaaacggc gacatccata tgggccatgc acttaacaag attttgaaag 1487401 acttcattgt ccgctataaa tcaatgagcg gctacaacgc accgtatgtg ccgggctggg 1487461 atacacacgg attgccaatt gaaacagctc tgacaaaaaa caaaaaggtc aaccgcaaag 1487521 aaatgtcagt agcggaattc cgcaaactat gcgaagagta cgcttggaag caaatcgagg 1487581 gacagcgtga gcaattcaaa cgtcttggtg tccgcggtga ctgggaaaac ccatatgtga 1487641 cattaaaacc ggaatacgaa gcgcagcaaa tccgcgtatt tggtgaaatg gcaaaacgag 1487701 gctacattta caaaggcctt aaaccggtta actggtcacc ttcaagtgag tctgctctgg 1487761 ctgaagccga gatcgaatat caagataaac gttcagcatc tatttacgtc gcttttggtg 1487821 taaaagacgg aaaaggcgtt cttgaaaacg gcgagcgcat catcatttgg acaacaacgc 1487881 cgtggacaat tccggcgaac ctcggaatct cagtgcaccc tgatcttgag tacagcgtga 1487941 ttgcagtagg tgaagaccgc tttgttgtag caagtgcctt agtcgaaaat gttgcatcgg 1488001 catgcggatt tgatcagtat gaagtgacaa gaacggtcaa agggaaagac cttgagaaca 1488061 ttatcgctga acacccgcta tatggcagag actctctcgt tatgcttggt gaacacgtaa 1488121 caactgatgc cggaacaggc tgtgttcata cagcgcctgg acatggggaa gatgacttta 1488181 tcatcggcca aaaatacggt ttagatgtgc tttgcccggt cgatgaaaaa ggtgtaatga 1488241 caagcgaagc tcctggcttt gaaggcatgt tctatgatga tgcaaacaaa gcgatcacac 1488301 agcagcttga tgaaaaaggc gcacttgtga agcttgaatt cattactcat tcttatccgc 1488361 atgattggag aacaaaaaaa ccaaccattt tcagagcaac agcgcaatgg tttgcgtcta 1488421 ttaaagattt cagatcagac ctgctggatg ccattaaaga aaccaaatgg gttcctgaat 1488481 ggggcgagca gcgtttgcac aacatggttc gggaccgcgg agactggtgt atttccagac 1488541 agcgtgcgtg gggtgtgccg attccggtat tttacgctga aaacggagaa ccggttatta 1488601 cagatgaaac cattgaacat gtttctgaat tgttcagaca gcatggatca aacatttggt 1488661 ttgaaaaaga agcaaaggat cttcttccgg aaggctttac gcatcctggc agcccgaacg 1488721 gcacatttac aaaagaacag gatatcatgg atgtttggtt tgattcaggc tcttcacatc 1488781 aagcagtgct tgaagaacgt gatgacctcg ttcgcccggc tgatctatac ctagagggat 1488841 ctgaccaata tcgcggctgg tttaactctt ctctttctac agcagtagcc gtaacaggga 1488901 aagcgccgta taaaggtgtg ctcagccatg ggttcgcact ggatggagaa ggacgtaaga 1488961 tgagtaaatc aatcggtaac gttgttgttc cggctaaagt catgaaacag cttggtgccg 1489021 acatcttaag attatgggta tcttcagtgg attatcaggc ggacgttcgc gtgtctgacg 1489081 ccattctgaa gcaggttgcg gaagtatatc gtaaaatccg caacacgttc cgtttccttc 1489141 acggcaacct tttcgatttt gatccaaaaa caaatgcggt ggctgtcgaa gatcttcgcg 1489201 aagtggatca gtatatgctg attaagctga acaagctgat tgataaagtg aaaaaagcgt 1489261 atgatgagta cgaatttgcg gttgtgtatc acagcattca taatttctgc acaatcgaat 1489321 tgagctcatt ctaccttgat tttgcaaaag atattgtcta catcgagcat gcggatcatc 1489381 cggatagacg cagcatgcag acagtattct acgaaacgct tcttgcatta gtgaagcttt 1489441 cagcgcctat ccttccacat acggcagacg aattgtggtc tcatttaaca tttgttgaag 1489501 agcagagcgt tcagttgacc gatatgccgg aaacaatcac ggttccaaac agtgaagcga 1489561 ctgaagaaaa atttgaccgc tttatggctc ttcgtgatga cgtgttaaaa gcattagaaa 1489621 ctgcgcgaaa tgaaaaaatt atcggtaaat ctttggaagc aaacctgaaa ttgtatccaa 1489681 acaaagaaaa caaggagctc ttggcttcca taaaagaaaa cctttctcag ctgtttattg 1489741 tgtctgaact gacaatcagc gaagaaaatg aagcgccgaa cgatgcgcaa agctttgcga 1489801 cgggtaaaat cgctgtcgag aaagcggaag gcgaaatgtg tgagagatct cgtgtgattt 1489861 caaaagatgt aggggcaaat ccgaaatatc ctacactttc attacgcaac gctgaaatcg 1489921 ttgaaaaata ctatcaaaaa taatgcaaaa gagcccggcg taaaagccgg gctttttttg 1489981 tgccaagagt gacatccttt agaacgaaag gaaaaatctt atgggcttta gatcatcatt 1490041 cacaggcaac aataaagata ctacgttaag agcaggagtt gtgaagaatg aatgatcaac 1490101 tgaccgcaat ttatacggaa cttcttctga tgaaagaaga attacagtcg agattatttg 1490161 agtattcttg ctttcaggtt tctacaagcc cgcaagcagc aatcaatcaa aaacaaaaag 1490221 caactctgat ctatcatatt aaagaagaac ttcaagacgt tctccttgca ttgtccaaaa 1490281 tcgaaaacgg cacattcgga tactgtgaag aaactggggc ccccattcct cttgcaaagc 1490341 tggcagtgct gccgacggcc cgaacagcaa acgattttct ttattctgtc caatttgaga 1490401 aaaaaacgct tccgatatgg aaatcaacgg atatcgaata tggtcaggca ctgtatgaat 1490461 aacagtgtct gtccggttaa tatgcctgat atttctttac tccagtgctt tttattgata 1490521 aaatgcataa tggattaaag taaccgtaaa ctggaggaac gtttgtgctg tattatatga 1490581 ttgcactact tattattgca gccgatcaat tgacaaaatg gctagttgtt aagaacatgg 1490641 aacttggcca aagcattccg atcattgatc aggtattcta tatcacctcc catcgcaata 1490701 cgggtgctgc atgggggata ttagcgggtc aaatgtggtt tttctacctc ataacaaccg 1490761 ctgttattat tggtattgtt tattacatac agcgttatac aaagggacaa aggcttcttg 1490821 gcgttgccct cggacttatg cttggcggtg ccatcggcaa ctttatcgat cgggctgtca 1490881 gacaggaagt tgtggatttt atccatgtta ttattgtcaa ttacaattac ccgatattta 1490941 acatcgcgga ctcttcacta tgtgtcggcg taatgctttt atttatacaa atgctgttgg 1491001 acagcgggaa aaagaaaaag gagcaatagc atgaatcaaa ttgatataac cgcttcagaa 1491061 gaacaaaaaa gtgagcggat tgataaattt ttggcatcga ctgagaatga ttggtcaaga 1491121 acccaggttc agcaatgggt aaaagacgga caggttgtcg tgaacggaag cgcggtgaaa 1491181 gcgaattata aaattcagcc gggtgatcag gtgaccgtca ctgtacctga accggaagcg 1491241 ctcgacgtcc tggcagagcc tatggatctg gatatttatt atgaggacca ggatgtgctg 1491301 gtcgtcaaca aacctcgcgg aatggttgtt cacccagcac ccgggcatct tacgggcaca 1491361 cttgtaaacg gtcttatggc tcattgcaca gacctttccg gaataaatgg tgtgatgcgc 1491421 ccgggtattg ttcacagaat cgataaggac acgtccggtt tattaatggt ggcgaaaaat 1491481 gatatggcgc acgagtcact cgtaaaccaa ttggtcaaca aaacggtcac gcggaaatat 1491541 acggcggttg tccacgggct tatttctcat gatgacggca caattgacgc gccgatcgga 1491601 cgggataaaa aagaccgtca aagcatgact gtgacacgtg atggcaaaaa cgctgtcact 1491661 cattttcatg tgcttgagcg ttttcaggat tttacgttag tggagtgcca gcttgaaaca 1491721 gggagaaccc atcaaattcg tgttcatatg aaatatatcg gattcccatt agcaggcgat 1491781 ccgaaatacg gcccaagaaa aacaatcgac tttaatggcc aagcgcttca cgcgggagtt 1491841 ttaggttttg accatccacg aacaggagaa tatgtcgaat ttgaagcgcc gcttcccgag 1491901 gatatggcag aattaatcga aaacctcaga aaaaacggtt gacagagggt ttcttttctg 1491961 aaataataaa cgaagctgaa tagattcttt aaaacagtcc agagaggctg agaaggataa 1492021 cggatagacg ggatgcgtgt ataggcgcgc accttgtcct aaaacccctc tatgctctgg 1492081 caggaggggt tttttcttct atatgaactg tgaggtgtca cacattgaat caaaaagctg 1492141 tcattctcga cgaacaggca attagacggg cgctgaccag gattgctcac gaaatgatcg 1492201 aacgcaataa aggaatgaat aactgcattc ttgtcggcat taagacaaga gggatttacc 1492261 tggcaaaacg ccttgcggaa cgcattgaac agattgaggg aaatcctgtt acagtcggtg 1492321 aaattgatat tactctttac agagatgatc tttctaaaaa aacaagcaac gatgaaccgc 1492381 ttgtaaaagg tgcagatatt ccggtagata ttacagatca aaaagtcatt ctcgttgatg 1492441 atgttctgta taccggaaga acagtcagag caggaatgga tgcgcttgtt gatgtaggca 1492501 gaccttcctc cattcagctt gcagtgcttg tggacagagg acaccgggag ctgccgatcc 1492561 gagcggatta tatcgggaaa aacatcccga catcaaagtc tgaaaaggtt atggtacagc 1492621 ttgatgaggt agaccaaaac gatctcgtcg ccatttatga aaacgaataa tagatcacct 1492681 ttttaagggc aatccagaga ggttgcaaag aggtgcacaa caaaggccca aaaagtattc 1492741 ggcaggtctt tgtatgcctc tttgcgtaaa aaagcaaaga ggttttttta tacagtcatt 1492801 gagtcatcct aaaatgaaag tcaacaatca gggggaaatc atcatgagta agaaaaaagt 1492861 aaatttaggg gtcagggatg tcccgacacc tttctcttgg gtttcattca gccttcagca 1492921 tttgtttgcc atgtttggct caaccatttt ggttccgaag ctcgtcggaa tgagtcctgc 1492981 tgtggcgttg gtgacaagcg gcatcggaac actggcgtac cttcttatta ccaaaggaca 1493041 aattccggcg tatctcggtt catccttcgc ctttatttct ccgatcattc tggtaaaagc 1493101 gaccggcggg ccgggagcgg caatggttgg agcgtttctt gcagggctgg tgtacgggct 1493161 gattgcctta ttgattaggc agcttggaac aggatggctg atgaagattc tcccgcctgt 1493221 agtcgtaggg cctgttatta tcgtcatcgg gctgggactg gcaagcactg cagtaaacat 1493281 ggcgatgtat gctgatccga acgcgagtga gttggtctac agcttaaagc actttagtgt 1493341 cgcaggagtt acgctggcaa ttacgattat ttgtgcgatt ttcttacgag ggtttttaag 1493401 cctgattccg gttctgatcg gaatcatcgg cggatacctg tttgccctta ctcaagggat 1493461 tgtcaacttc cagccggtgc ttgacgcgaa atggtttgca gtgcctgaat ttatcattcc 1493521 gttcaaagat tattcaccgt cagttacgct cggcatcgca gccgcaatgg ttcctgtcgc 1493581 atttgtcaca atgtcagagc atatcggcca ccaaatggtg ctgagcaagg ttgtcggaca 1493641 agacttcatt aaaaagccag gtcttcatcg ctctattatg ggtgacagtg tggcgacaat 1493701 cctcgcttcc ctgatcggcg gccctccgac aacgacttac ggagaaaaca ttggcgtgct 1493761 ggccatcaca agagtattca gcgtctttgt catcgggggc gcggcagtga ttgccctttg 1493821 cttcggcttt atcggcaaaa tttcagcgct gatcagttca gtgccgtcag cggtcatggg 1493881 aggcgtctcc ttcctgctgt tcggaatcat tgcttcaagc ggcctgagaa tgctgattga 1493941 caacaaaatt gattatgaaa acaacagaaa cctcattatt acatcagtta tccttgtcat 1494001 cggtgtagga ggcgctttta tccaagtgtc tcagggcgga ttccaagtgt caggaatggc 1494061 gcttgccgca attgtcggtg tcatcttaaa cctgattctt ccgcaggcga aggaagagca 1494121 ggcagacaca tctgaacaac atcatattta aaacctttta atgaaagtcc agagaggctt 1494181 ggaagggtta tgaagagaag gaagcttcaa tgctgccctc tatttaacca taccccgagt 1494241 ctatcttaga ccggggtttt ttttcagcct taagttgaaa agagagggga aagaacatga 1494301 agcatttaac gacgatgagt gaacttagca ctgaggaaat caaagatttg cttcaaacag 1494361 cacaagagct caaaagcgga aaaacagaca atcagcttac aggaaagttt gcagcaaacc 1494421 tgtttttcga accgagcacg agaacgcggt tcagctttga ggtcgcagaa aaaaagctgg 1494481 gcatgaatgt gcttaacctt gatggaacaa gcacaagcgt gcaaaaaggc gaaaccttat 1494541 atgacacgat ccggacgctt gaatcaatcg gtgtggacgt ctgcgtcatc aggcacagtg 1494601 aggatgagta ttatgaagag cttgtcagcc aggtgaacat tccgattctg aatgcgggag 1494661 acgggtgcgg ccagcatcca acacaatcac tgcttgattt aatgacgatt tatgaagagt 1494721 tcaatacgtt taaagggctt accgtctcca ttcacggcga catcaagcat agcagagtgg 1494781 caaggtcaaa tgcggaagtg ttgacaagat tgggtgcccg ggtcctattt tccggccctt 1494841 cggaatggca ggatgaagaa aatacattcg gcacgtatgt ctcaatggat gaagcagttg 1494901 agtcttccga tgttgtcatg ctgctgcgca ttcaaaatga acgacatcag tccgctgtca 1494961 gtcaggaagg ctatttaaac aaatacggct tgaccgtaga acgggctgag cgtatgaagc 1495021 ggcatgcgat catcatgcat cctgctccgg taaacagagg agtggagatt gatgacagct 1495081 tagtagaaag cgaaaaatca agaatcttca agcaaatgaa aaatggcgta tttatcagaa 1495141 tggcagtgat acagcgtgcc ttacaaacca atgtgaaaag aggagaagca gcgtatgtca 1495201 tatctcatta aaaacggctg gatactaaac gaaaatggtg aaaaaacaca agcggatatc 1495261 cgagtgactg gagaaaccat caccgcaatc ggcaagcttg atgcaacgga taatgaaacg 1495321 gtaattgatg caaaaggttt gctcgtttca cctgggtttg ttgatctcca cgtgcatttc 1495381 agagagccgg gcggagagaa aaaagaaact attgaaaccg gggcaaaagc agcggcgcgc 1495441 ggcggctata ctacagtagc agcaatgccg aatacgcggc cggttcctga tacaaaggag 1495501 cagatggaat gggtgcaaaa cagaattaaa gaaacatcat gcgtaagagt tcttccatat 1495561 gcatccatta cgatcagaca aatcggcgat gaaatgacaa actttgaagc gttaaaagaa 1495621 gccggggcat ttgcttttac agatgacggc gttggtatac agacagcagg aatgatgtat 1495681 gaagcgatga aacgggcagc cgcaattgac aaagcgattg ttgcacattg cgaggacaac 1495741 tccttaattt acggagggag cgtacatgag gggacattct ccaaagcgaa cgggctaaac 1495801 ggcattcctt ctgtgtgtga atcggttcat attgctcgcg atgtgctgct ggctgaggcg 1495861 gcaaactgcc attatcatgt atgccatatc agcacaaaag aatctgtcag agttgtacgc 1495921 gatgcgaaaa aagcgggaat cagagtgaca gcagaagtat cgccgcatca tttgctgctt 1495981 tgtgatgagg acatcccggg gctggacaca aactataaaa tgaatcctcc gctccgcagc 1496041 ccagaagaca gagctgcttt aattgaaggt cttttagacg gaacaattga ttttatcgca 1496101 acagaccatg caccgcatac ggaagaagag aagaacacag aaatgaagct ggcgccattc 1496161 ggaattgtcg gcttagaaac agcattcccg cttctttaca cacactttgt caaaaatggc 1496221 agctggtcac tgaagcagct gattgactac atgacaatca agccatgcga agcgttcggt 1496281 ctcccatatg gaacattaca aacggggcaa gctgcggaca ttacgttaat cgatttagaa 1496341 aaagaagcag ttatagacaa agagacattt ttatcaaaag gaaaaaatac accattcaac 1496401 ggcatcagtt gcaccggctg gccggtcgct acaattgcgg cagggaagct tgcttatgaa 1496461 gaggggagac ttgtcaaatg aagagacgat tagtactgga aaacggagcg gtattcgagg 1496521 gagaagcttt cggaagctta gaacacaaca tgggagaagt cgtttttaat actgggatga 1496581 caggctatca ggaaatttta tctgatcctt cttactgcgg acagatcgta acattaacat 1496641 acccgcttat cggaaattac ggcattaacc gtgatgattt tgaatccatt accccttttg 1496701 tcaaagggct gatcatcaaa gaattatgtg agctgccttc caactggcgt tcagcataca 1496761 ccttagacga gtatttaaaa atgaaaaaca ttcccggact ccagggaatt gatacaagga 1496821 agctgacaag aatgatccgc acggcaggcg cgctaaaagg aacattcgct tcatctgatg 1496881 aagatatcga agcagtgctg aaaagactga acgaaacgga attgccaaga aatcaagtat 1496941 cccaagtatc agcaaaaaca gcatatccga gcccgggaag aggcaaacgc attgtcttgg 1497001 ttgacttcgg catgaaacac gggattctaa gagagctgaa caaacggaaa tgtgacgtca 1497061 tcgttgtgcc ttacaacatt acagcggaag aggtgcttca gctgaaaccg gacggtatca 1497121 tgctttctaa cggacctgga gacccgaagg atgtgcctga agcgattgaa atgattaaag 1497181 gtgttcttgg aaaagtgcca ttattcggaa tatgtctcgg ccaccaatta ttcgcgctgg 1497241 cgtgcggggc gaatactgaa aaaatgaaat tcggccacag gggctcaaac cacccggtaa 1497301 aagagctggc tacaggaaaa gttgccttaa catctcaaaa ccatggatat acagtttcgt 1497361 ctatcagtaa aacagaactg gaagtgacgc atatcgcaat taacgacgat acgattgaag 1497421 ggctgaagca taaaacattg ccggcattta cggttcaata tcatcccgaa gcctcacctg 1497481 gtcctgagga tgccaaccat ctatttgaca gattcatcga aatgatcgaa acaacagaga 1497541 aagaagggga agcggtatgc caaaacgcgt agacattaac aaaattttag taatcggatc 1497601 tggaccgatc atcatcggcc aagcagcaga atttgactat gcgggaacac aagcctgtct 1497661 tgctttgaaa gaagaaggct atgaagtcat ccttgtcaac tcaaaccctg caacgatcat 1497721 gacagataca gaaatggctg accgggttta catcgaaccg ctcacacctg aattcctgac 1497781 acgaatcatc agaaaagagc gcccggatgc cattcttcct acactcggag gccaaaccgg 1497841 tttgaatctt gcggttgagc tttctgaaag aggcgttttg gcagaatgcg gcgtcgaagt 1497901 gcttggcacg aaactgtctg cgattcagca agctgaagac cgtgacttgt tcagaacatt 1497961 aatgaatgaa ctgaatgaac cggtgcctga aagtgagatt atccactccc ttgaagaagc 1498021 agaaaaattc gtcagtcaaa ttggattccc tgtcattgtc cgcccggcat atacattagg 1498081 cggaacaggc ggaggcatct gctcgaatga aacagagcta aaagaaatcg ttgagaacgg 1498141 cttgaaatta agcccggtac accaatgtct gcttgaaaaa agcatcgccg gctataaaga 1498201 aatcgagtat gaagtcatga gagacagcca ggatcacgcc attgtcgttt gtaacatgga 1498261 aaacattgat ccagttggaa tccatactgg agacagtatt gttgtcgcgc cgagccaaac 1498321 gctcagcgat cgcgaatatc agctcttgcg gaatgtatcg ttaaaactga ttcgcgcgct 1498381 tgggatcgaa ggcggatgta atgtccagct cgccttagat ccagacagct tccaatatta 1498441 cattattgaa gtaaatccgc gtgtcagccg ttcatctgcc cttgcatcaa aagcaacggg 1498501 gtacccgatt gcaaagctcg ctgctaaaat tgcagtcgga ctttcattag atgaaatgat 1498561 gaacccggtg acaggaaaaa catatgcagc atttgaacct gctcttgact atgtcgtatc 1498621 caaaattccg cgctggccgt ttgataagtt tgaatcagca aacagaaagc ttggcacgca 1498681 aatgaaagcg acaggtgagg tcatggcaat cggccgcacg cttgaagagt cattgctgaa 1498741 ggcagtgcga tcactggaag cggatgtgta tcatcttgaa ttgaaggacg ccgctgacat 1498801 ttcagatgag cttcttgaaa agcgaattaa aaaggccggt gatgaacgct tattctactt 1498861 agctgaagcg tacagaagag gctacacggt agaagacctc catgaatttt ccgctatcga 1498921 tgtcttcttc ttgcataagc tgttcggaat cgtacagttt gaaaaagaat tgaaggccaa 1498981 tgcgggcgat acagatgtgc tgagacgggc aaaagaactc ggcttctctg atcagtacat 1499041 cagccgtgaa tggaaaatga aagaatctga gctttacagc ttgagaaaac aagcggggat 1499101 tgcgccggta ttcaaaatgg tagatacatg cgcggcggaa tttgagtcag aaacgccata 1499161 cttctatagc acatatgaag aagaaaatga atctgtcgtt acagataaga aaagtgtgat 1499221 ggtgcttggt tcgggtccga ttcgaatcgg tcagggtgtc gagttcgact atgcgacggt 1499281 tcactctgta tgggcaatta aacaagcagg ctatgaagcc attattgtca acaacaaccc 1499341 ggaaaccgtt tcaacagact tcagcatctc agacaagctg tattttgaac cgcttacgat 1499401 tgaagatgtc atgcacatca ttgacctcga acagccaatg ggcgttgtcg tacaatttgg 1499461 cggacaaact gcgattaacc ttgctgacga gctttctgca cgcggagtga aaatccttgg 1499521 aacttcatta gaagatttag accgtgccga agaccgggat aaatttgaac aagcgcttgg 1499581 agaacttggt gttcctcagc cgcttggcaa aacagcgaca tcagttaatc aggcggtaag 1499641 catcgcaagt gatatcggtt atccggtact ggtacgccct tcctatgtac ttggcggccg 1499701 ggcgatggag attgtttacc atgaagagga actgcttcat tacatgaaaa atgcagtcaa 1499761 aatcaatcca cagcaccctg tattaattga tagatacttg accggaaaag aaattgaagt 1499821 cgatgcagta tccgacggtg aaacagtcgt cattccggga attatggagc acattgaacg 1499881 tgcgggcgtt cactccggag actcaatcgc tgtttatccg cctcagtctc tcacagagga 1499941 cattaagaaa aaaattgaac aatacacgat cgcattggct aaagggctga atattgtcgg 1500001 tttgctcaat attcaattcg tcttgtcgca aggcgaggtg tacgtgctag aagtgaatcc 1500061 gagatcaagc agaaccgtac cgtttttaag caaaattacg ggtatcccaa tggcgaatct 1500121 cgcaacaaaa atcattcttg gtcaaaagct ggctgcgttt ggctatacag agggccttca 1500181 gcctgaacag caaggtgtat ttgtaaaagc gccggtcttc tcctttgcca agctgagaag 1500241 agtggatatt acgttagggc ctgaaatgaa atcaacaggt gaagtcatgg ggaaagattc 1500301 gacacttgaa aaggcgctct acaaagcctt gatcgcttca ggtattcaaa tcccgaacta 1500361 cggttccgtg cttttaacag tagctgataa ggacaaagaa gaagggcttg ccattgctaa 1500421 gcggttccac gcgatcggct acaacatttt agcgacggaa ggaacggcag gctacctgaa 1500481 agaagcttcc attccagcga aggtcgtcgg aaaaatcggt caggatggcc cgaacttgct 1500541 tgatgtcatc agaaacggag aagcgcagtt tgtcatcaat acgctgacaa aaggaaagca 1500601 gccggcaaga gacggtttta gaatcagacg tgaatcagta gaaaatggtg ttgcctgcct 1500661 aacatcttta gatacggcag aggcgatatt gcgagtgctg gaaagcatga cattccgtgc 1500721 tgatcaaatg ccggcagtca acacaaatca ggaggcggca gtcactatat gaaaaaagcg 1500781 tatttgacag tatgttctaa ccagcaaatt gcagaccggg tgtttcaaat ggttctgaaa 1500841 ggggagcttg tccaagggtt tacaacccct ggacagttcc ttcatcttaa agtgagcgaa 1500901 gcggttacgc ctcttttgag aaggccgatc agcatcgcag acgtcaactt tgaaaaaaat 1500961 gaagtcacca tcatttatcg ggtagatggg gaagggacaa gactcttgtc actgaagcag 1501021 cagggagaac ttgtggatgt cctcgggcct ttgggaaatg gctttcctgt taatgaagtt 1501081 caacccggaa agacggcttt gctggtagga ggcggagtag gtgtgccgcc tctccaagag 1501141 ctgtcgaaac gcttgattga aaaaggggta aatgtcatcc acgttttagg attccaatcg 1501201 gcaaaggatg ttttttacga ggaagaatgc cggcagtacg gagacacgta tgtggcaaca 1501261 gctgacggaa gctacgggga aaccggattt gtcacagatg tgattaaacg gaaaaagcta 1501321 gagtttgata tcctcctcag ctgcgggccg acaccgatgc tcaaggcgtt aaaacaggaa 1501381 tatgcccata aagaagtata tctgtccatg gaggaacgaa tgggctgcgg aatcggcgca 1501441 tgcttcgcgt gtgtgtgcca tacaaacgaa agtgagacat cctatgtaaa agtatgtctc 1501501 gacgggcctg tatttaaagc tcaggaggtg gcgctgtaat gctagaggtg aaattgccgg 1501561 gacttgattt gaaaaaccca atcattcctg catcaggctg cttcggtttt ggaaaagaat 1501621 tttcacgttt ttatgatttg tcttgtcttg gagctatcat gattaaggct acgacaaagg 1501681 agccgcgctt tgggaatccg acgccgcggg tagctgagac tggtgctgga atgctcaatg 1501741 cgatcggtct ccaaaatccg gggctggata gtgtgttgca tcatgagctg ccgtggcttg 1501801 agcagtttga tacaccgatc attgccaatg tcgcaggttc tcaagtcgat gattatgttg 1501861 aagtcgcaga acatatcagc aaagcgccta atgttcatgc tcttgaattg aatatttcct 1501921 gcccgaatgt gaaaacaggc ggaatcgctt ttggcacgaa tcctgaaatg gctgccgatt 1501981 tgacaaaagc ggtgaaagag gtttcggatg tacccgttta tgtgaagcta tccccgaacg 1502041 tggctaatat cacagaaatt gcattagcga tcgaggaagc gggagcggac ggtcttacga 1502101 tgatcaacac actaatcggc atgagactcg atttaaaaac cggcaaaccg atattagcga 1502161 ataaaacagg gggactttcg ggccctgctg tgaagccggt tgccattcgc atggtgtatg 1502221 aagtcagcca gatggtcaac atcccgatta tcggaatggg aggcgtgcaa acggctgaag 1502281 atgccctgga atttcttctc gcgggagcaa gcgcagtcgc tgtcggaaca gcaaactttg 1502341 tgaatccttt tgcatgtcca gagattattg aacagctccc atctgttttg ctccaatacg 1502401 gctatcaatc aattgaagaa tgcatcggaa ggagctggaa tcatgaaaaa caacctgccc 1502461 atcatcgcgc ttgattttgc gtcagctgaa gaaacacttg cgttcttagc gccttttcag 1502521 caagaaccgt tatttgtaaa ggttgggatg gagctttttt atcaagaagg gccatctatc 1502581 gtgaaacaac taaaagaaag aaactgcgag ctatttttag atctaaagct tcatgacatc 1502641 ccgactactg taaacaaagc gatgaagcgc cttgccagtc ttggagtaga cctcgtcaat 1502701 gttcatgctg ccgggggcaa aaaaatgatg caggcagctc tcgaaggctt agaagaaggt 1502761 acgccggctg gaaaaaaacg tccgtcactt atcgcggtaa cccagctgac aagcacatct 1502821 gaacaaatca tgaaagatga actgctgatc gaaaagtctc tgattgatac ggttgtgcac 1502881 tacagcaaac aggcggaaga aagcggactg gatggagtgg tctgctctgt tcatgaagca 1502941 aaagccattt accaagcggt gtcgccttca tttctgactg tcactccggg gatcagaatg 1503001 tcagaggacg ctgcgaatga ccaagttcgc gtagcgacgc ctgccattgc aagagagaaa 1503061 ggttcatcag cgattgtagt aggacgctcg attacaaaag cggaagaccc ggtaaaagcc 1503121 tataaggctg tcagacttga atgggaggga atcaaatctt gaaacaaatc atcgcaaaac 1503181 atctattaga catccaagct gtatttttac gcccgaacga gccgttcaca tgggcaagcg 1503241 gcattttatc accgatctac tgtgacaacc gccttacgct atctttccca gaggtcagaa 1503301 acgatgttgc ttcaggtatc agcaagcttg ttaaagagca ttttcctgaa gctgaaatga 1503361 ttgcgggaac agcaactgcc ggtattcctc atgctgctct tgcggcggac catttgaatc 1503421 ttccgatgtg ttatgtgagg agcaagccga aggcgcacgg aaaaggcaat cagattgagg 1503481 gagctgtgca agaagggcaa aaaacagtcg tcattgaaga cttaatttcc acaggaggca 1503541 gcgtgcttga agcttgtgca gctttacaag cggccggctg tgaagtgctt ggtgtcgtct 1503601 caatctttac gtacggactt cctaaagcgg aggaagcctt cgcaaaggca gaactgccat 1503661 actactcatt aaccgattat gatacgctca cagaggtcgc gcttgaaaac ggaaatattc 1503721 attcagatga tctaaaaaag ctgcaaacat ggaaacgaaa tcccgagtca aaagattggt 1503781 ttaaaaaata aaaaataaat tcaaatgatg taaagaggct tcaaagcctt gctgtacttg 1503841 aaaacaggct gtgaggcctg tttttttatt aatcctataa aaaaagtcgg gttgacttat 1503901 gttagaattg tgctaaaatt tactacaaat ctaaaaactt atcaagagcg gctgagggac 1503961 tggacctatg aagcccggca acctgcatag tttgtaaggt gctacttcca gcaaaatgaa 1504021 ttccattttg aaagataagg gctgcatgct gttcctgtct ttctttccgc cggattgaaa 1504081 gttttttatt ttaagaggta aaaaggctat ctgtatatca gcagccgcga atcacattac 1504141 atgggaaaag acaaccggca gaaagctact gtttgtttgt ctccgaaagg aggaaagaag 1504201 aaatgttaac gtatgataat tgggaagaac caacgattac atttccggaa gacgatcctt 1504261 ataaaggagc gctgtcagtt ttaaaatggg catacggcca ttacggcgat cagcttgttt 1504321 atgcctgcag tttcggaatt gagggaatcg ttctgattga cttaatttat aaagtgaaaa 1504381 aagacgcaga gattgtgttt cttgatacag gacttcattt taaagaaacc tatgaaacaa 1504441 ttgaacgagt gaaagagcgt tatccgggtc ttaatatcat cctgaaaaaa ccagatctca 1504501 cccttgagga acaagccgaa gaacatggtg acaaactatg ggaaagagag ccgaatcagt 1504561 gctgctatct tagaaaggtc gttcctttaa gagaggcgct ttcaggacat ccagcctggc 1504621 tttccggcct gcgccgtgat caagggccaa gccgtgccaa tacgaatttc ttaaacaaag 1504681 atgaaaaatt caagtcagta aaagtttgcc cgcttatcca ttggacttgg aaagacattt 1504741 ggagatatac atcccggaat gaactggact acaatccgct tcatgaccaa ggctatccaa 1504801 gtattggctg tgcgccttgc acttctcccg cttttacagc agaagatttg cgctcaggca 1504861 gatggaatgg tatggcgaaa acagaatgcg gactgcatga ataaggagct gcaaaatgga 1504921 attagccgct attttattta gcttgttttt cgcgatgaat attggtgcaa gcggcgctgc 1504981 agcttcgatg ggggttgctt acggctccgg agccatcaaa aagaaaactt acgctttgat 1505041 cctatgcgca gtcggtgtct ttgccggggc ggtcattggc ggaggcgagg ttgtaaaaac 1505101 aatcagctcc ggcattattc ctgagcagac gattacactg acgattgttt gcatcattat 1505161 tggagctgct gccctgtcgc tctttactgc taatctgctc ggcattcctt tgtcgacaag 1505221 tgaagtaaca gtcggcgcgg ttgtcggcgt gggagtggct tataaagtat tgtttgtgaa 1505281 caatcttctg atcattgtgt cattttgggt ttttgtcccg ctgttcgctt tcggcttcac 1505341 ctatttcgta tctaagctgt ttcgttattt taagattgaa gtaaaatctt ctaaaaagca 1505401 aaaaatcctc ggcattgttt tgttagttgc cggatttttc gaagcattct ctgccggcat 1505461 gaataacgtg gcgaatgctg ttggcccgtt agtagctgcc ggtgtgcttg atgtcggaaa 1505521 aggaaccttg tatggaggag cttttgttgc tcttggcgca ctgttattag gccggcgagt 1505581 gctagaaaca aacgggaaga aaattacgag gttctccaaa ggggaaggca ttctcttatc 1505641 cggtacagga gcgggactgg tgatcatcag ttctgtattt gggatgccgg tgcccttggc 1505701 gcaagtcacg tcatcgtcta ttatcggaat aggcatggcg aaaaacggtc cgaacgtgtt 1505761 ccataaacaa gttgttcaaa cgatgctgaa ggtatggatc gtatcgccgt ttttatcttt 1505821 atcgatttct tatctgcttg tatccttgtt tttaaaagca gattattatt cgatctttat 1505881 catggtaagt gtgcttttag cggcgggcgg tgccatcagc ctgacaaagg ccattcgtaa 1505941 agagagacgc tcagtccacg aacaaggcgg gggaatctga tcattaatct gagtaatttt 1506001 ataagttaac taggaggaga tggatattat gagcttagca ccacacggag gaacattagt 1506061 aaacagagta gatgaatcat atgatgtgag cggcattcaa aaagaaattg aacttgattt 1506121 aatttctttc gcggatttgg aattgatcgg tatcggtgca tacagcccga ttgaaggttt 1506181 ctttaatgaa aaagattacg tatcagtggt cgaaaacatg cgtctttctt ccggcgttgt 1506241 ctggtctctt ccaatcacgc ttccggtcga tgcgcaaaaa gcagcggaac tgtcacttgg 1506301 tgaaacggta aagttaacgt atgaaggaga aacttacggc gttatccaaa tcgaagacct 1506361 gtacgtgcct gacaaacaaa aagaagctgt caatgtgtac aaaacagatg aacaggagca 1506421 tcctggtgtt aaaaagctgt tcagccgcgg caatacatat gtcggcggac cgattacgtt 1506481 gattaaaaaa gcttcaaaac agttccctga atttacattt gaaccgtcag aaacgagacg 1506541 ccagtttgcg gaaaaaggct gggaaaccat tgtcggtttc caaacaagaa accctgttca 1506601 cagagcgcat gaatacattc aaaaaacggc tcttgaaaca gtagacggct tgttcttgaa 1506661 tccgttagta ggtgaaacaa aatctgatga cattccagct gatgtacgga tggaaagcta 1506721 ccaagtgctt cttgatcatt attacccgaa agatcgtgtt ttccttggtg tctttttagc 1506781 ggcgatgcgt tatgcaggcc cgagagaagc aattttccac gcgcttgtca gaaagaacta 1506841 cggctgcaca catttcatcg tcggccgtga tcatgcaggt gtaggcgact attacggaac 1506901 atacgaagca caggaactgt ttgacacatt taaacctgaa gaactcggaa ttacaccgct 1506961 gaaatttgag cacagcttct tctgtaaaaa atgcggaaat atgggaacag caaaaacttg 1507021 ccctcatggc agagagcatc acgtcatttt atcaggcact aaggtaagag gtatgctgag 1507081 agacggtgtg ctgccgcctg ctgaattcag tcgaaaagaa gtagtagaag tgttaatcaa 1507141 agggatgaag aaaaaagaag aagtaggcgt atcttaagga ggactggcag tgacaaatcg 1507201 cgatattgta tggcatgaag cctctatcac aaaagaagag tatcagcaaa aaaacaagca 1507261 taaaagctcc attctctggc tgacagggtt aagcggctca ggcaaatcaa ccattgccaa 1507321 cgccgctgcg agagaattgt ttgagcaagg ctaccaagtc attgtgctgg acggggataa 1507381 tatccgtcac ggcctaaata gggatcttgg tttttctgat gaagaccgaa aagaaaacat 1507441 ccgccggatc ggagaggtgg cgaagctttt tgttcagcag ggaaccattg tgattactgc 1507501 ttttatctct cctttccgcg aggacagaca acaggttcgc gagcttgtgg aagcgggcga 1507561 atttaatgaa gtctacatta aatgcgacct tgatatttgt gaacaaagag atccgaaagg 1507621 gctttacaaa aaagcaagaa acggcgagat tccgttcttt acaggaattg attctcctta 1507681 tgaagaaccg gaagctccag agctcgttct tgattcagga cagcatgacc gtgaagcgtg 1507741 taaaaatcag ctgatcgagt ttgttaaaca aaaattgagc tgaatatgat ctgctgcgtt 1507801 cttctcagat gccggaatgc aagcgagaac atcatcacag cgaatcttct ggaagaactc 1507861 gaatagatcg ggggaaatac gatggggaaa gtatatattg taggagcggg tcccggtgac 1507921 cctgatctgc tgacaattaa agcgctgaaa gccattgaaa aagctgatgt catcttatat 1507981 gacagattag taaataaaga gattttacaa tatgccaaag agcaagcaga cctgatctac 1508041 tgcgggaagc ttccggattt tcatacgatg aagcaggaaa ccatcaatcg atttcttgtg 1508101 aagtatgcgc aaaaagggaa aatggttgtc agactgaaag gcggagaccc ttttgtgttc 1508161 gggagaggag gggaagaagc ggaatgcctc tctgaaaatg gaattccgtt tgaaatcatt 1508221 cccggcatta cgtctggaat cgcggcagcc gcttatgccg ggattcctgt tacccatcgg 1508281 gatgcgggct ctaacgtcgc ttttgtaacg ggtcactata aaaaagaaga agattttgag 1508341 gaaaagtgga aagcgctggc tacaggaatt gatacacttg tcatctatat gggtatcaaa 1508401 aacgtgcagc agattgaaag aaaactcctt gaaaatggcc gggacggttc tacgccagca 1508461 gcctttattc attgggggac aacggacaag caaaaatctg ttttttgtac agttgacacc 1508521 ctttcagaaa cggtgataaa agaaaacatt acaaatccga gtttaattgt cattggaaat 1508581 gttgtaaatt atcactataa gctggaatgg tttgaatctg aactaaaaaa acaagattta 1508641 agcgaggcgt tgtaaaaatg aaacaagcaa ttttatatgt cggccacggc agccgggtca 1508701 aaaaagcgca gcaagaagcc gcagcctttt tggaaggatg caaggcccac atctctgtgc 1508761 cagtacaaga aatcagcttt ttagagcttc aggagccgac aattgagaca ggatttgaag 1508821 catgtgtgaa gcaaggtgcc actcatatcg cagtggtgcc tctgcttctt ttaacagctg 1508881 cgcatgcaaa acatgatatt ccggaagaaa ttgtccgtgt tgcatctcga tatccatcag 1508941 tccgtatttc atacggaaag ccgatcggga ttgacgaaga agtagtcaag gctgtatatc 1509001 accgaatgaa agacataggt gttccgtatg aaaatgccag agtggtgctc atcggaaggg 1509061 gaagttcaga tccagacgtc aaaagagacg taaccggaat tgctaatctt cttcaggaaa 1509121 tggttccagt gaaggaagtc attccgtgct ttttgacagc atgcggccct aattacaaag 1509181 aggttttttc agaacttgaa aaagatgacg gcataacaac ctttatcgtt ccatatttgc 1509241 tttttacggg tatgctgatg aatgaaatcg aacgagaggt tcagaaatta aaagcccata 1509301 atccgaacgt ctacctctct tcctatatcg gttttcatcc tcatgtgaaa aacgcatttt 1509361 tgaaccgtgt gagagaaact gcggcaaatt ctgagggaca atttgatttt gatggaggtt 1509421 catatgcttc cgctgcacat tagcctggaa aagaagaagg ttgtgattgc ggggggcgga 1509481 agcatcgctc tcagaaggct gaaaacggtg atttctgagg gagctgatat aacgcttgtc 1509541 agtccggatg tggaaccgga aatcaagcaa atggcagaag agcggcgtat caaatgggaa 1509601 aaacggacaa ttgaaaaaga agattatctc aatgctttct tcattattgc tgcgacggat 1509661 aatgcggcag tgaacaaaga aattgcccaa tccgcttcgc cttttcagct tgtcaattgt 1509721 gtcagtgacg ctgagcttgg caatgtatat atgccgaaaa tcgtaaaaag agggcatgtc 1509781 actgtgtctg tttctacaag cggagccagt ccaaagcaca cgaaagagct tgctgaaaac 1509841 gtggataagc tgattgacgg cgattttgtt gctgaagtga acaggcttta tcagatgaga 1509901 agaaagaaat aagccagagc atacaaatgc tctggctttt ctttatgcgg ctcagctttt 1509961 tttgagcttg atgacagtat cagcatcagg cgtgacaaag acggtatgct ggctgtcata 1510021 agtgacgaaa ccgggtttcg cgccgtttgg ttttttgaca tgcctgattt ttgtataatc 1510081 tacaggcact gaacttgaat ctttagcttt tgaaaaataa gctgcaattg tcgcggcttc 1510141 catgattgtt tgctcatcag gttcgctgct tctgatcaca acgtgggagc cgggaatgtc 1510201 cttcgtgtga agccagatat cgtctctggc cgccactctt gtcgttaaat attcattttg 1510261 acgattgttc ttacccacta aaattgtcag ccctgaggtg gattcatatg tttctaacac 1510321 cggattgtgc ggtttttgct ttttctggcc tttttgctgc ttagggcgta aatatttgcc 1510381 ctcaacaagc tcttccctga tttcgctgat atcccgggga gaagcggacg aaagctgctg 1510441 aatcagctga tcaaaatatt cgatctcttc ctgtgccagc ctgatttgct cctcgacaac 1510501 tgcgaccgaa tttttcgctt tctgatactt cgtgaaatag gcctgtgcgt tttcagaagg 1510561 cgttttgttc gggtttaaag gaatcgtgat tgtcgggctt tcttcatcat aataattgat 1510621 gacctcagcc tgtttatcac cttttttcag catatataaa ttagcggtta aaagctctcc 1510681 gtaaagctga aattccttcg cgttttccga atactccagg gttttctcta attttttgat 1510741 tttgttggca ttcttcttcc gttcgttcac aacaaaacgc tcaagatcct gagcctgttg 1510801 cttaacccgg tctcgttcag cttttccgaa ataaaaacgg tcgagcagtt cgcttaatga 1510861 atcaaaacgg cgcgcttcgc cctttagatg agtcagctcc agcagataaa aatattcctt 1510921 tccgtttaca gtcgtaatgt tgggaatgaa acggtgctct ttcacttcgg caaacagtgc 1510981 cagcaacgct tttggcagtg tgactttgtt ggcaaggcct gctctgtgaa ccgcttcttt 1511041 ggcgaaaagc ggagacacgc ctgaaaagtg gtcgacaatt tgtttatcaa gccttccttc 1511101 ttgaaagctg aggtgacgca aaatatcatc ttctgacgcc tcaagaggcg atattttgtc 1511161 ctgagcaggc ggaagcttat aatcttggcc gggcagtact gtacggtagc tgttcattga 1511221 cggtgataaa tgcttaagtc cgtcgataat cacattttct gctgcgtcag tcaaaatgat 1511281 attgctgtgg cggcccataa tttctacata aagctttcgt acggtttcat cgccaatttc 1511341 gtttcggctt ttgatatgaa aaatcataat gcggtctaag cccgcttgtt caattttctc 1511401 aatgaatccg ccttcgatat gctttctcag caacatgcaa aacattggcg gttcgcttgg 1511461 attttcataa gcttgtgccg tgatatgcac ccgtgaatag ctcggatgtg ccgataataa 1511521 tagtttttgg ttttttccct tggcacggat gtggaaaatc acatcgtgct tatatggctg 1511581 atggattttt gtaattcgtc cgcccattat tttctcgtta agttcgtgtg tcattccgta 1511641 tgtaaacatg ccatcaaacg acatatgcaa tacaccctct cattcttcct gcattcgata 1511701 attatagcat gaaatgggac gagtcagaat aagcatgctt atagagtgat atctctataa 1511761 gagagcaggg gagtggacga gcggaatgaa gtttcatgaa atgggacaaa cagatttact 1511821 agaggcaacc aatacgtcca tgaaacaagg attaacagaa aaagaggtaa aaaaacgcct 1511881 tgacaagcat ggaccaaacg agctgcaaga agggaaaaaa acttcagcgc ttctcttgtt 1511941 tttcgcgcag ttcaaagatt ttatggtgct tgtgcttctg gcggcaacgt taatctcagg 1512001 atttcttggt gaatatgtag atgcggttgc gattattgcg attgtgtttg tgaatggcat 1512061 actcggtttc tttcaagaaa ggcgtgctga gcaatctctt caggctttaa aagagctttc 1512121 aacaccgcac gtcatggcac tcagggaagg aagctggaca aagattcctt ctaaggaact 1512181 ggtgccgggt gatattgtga aatttacgag cggggacaga attggcgcag acgttcgaat 1512241 tgttgaagcg agaagccttg aaatagaaga atcagcgcta accggggaat caatcccggt 1512301 tgtgaagcat gctgataaat tgaaaaaacc ggatgtttca ctcggcgata ttaccaatat 1512361 ggcatttatg ggtacgattg tgacccgcgg cagcggtgtc ggggttgtcg tcgggacagg 1512421 aatgaatacg gctatgggga aaattgccga catgcttgaa tcggcaggga cattgtcaac 1512481 cccgctgcaa agaagactgg agcagctcgg gaagattttg attgttgttg cattgcttct 1512541 gaccgtactt gtcgttgctg tcggtgttat tcagggtcat gatctgtaca gtatgttttt 1512601 agcaggtgtc tcgttagcgg tagccgctat tccggagggg ctgccggcga ttgtgacagt 1512661 ggcgctttcg cttggtgtac agaggatgat taaacaaaaa tccattgtta gaaagcttcc 1512721 tgctgttgaa acgcttgggt gtgcgtctat catttgctca gataaaacag ggacaatgac 1512781 ccaaaacaaa atgacagtga cgcatgtctg gtccggaggg aaaacatgga gagtggcagg 1512841 ggccggctat gaaccgaaag gaagcttcac actaaacgaa aaagagatca gtgtcaatga 1512901 acataagccg cttcagcaga tgcttctgtt cggagcgctt tgtaacaact ccaatattga 1512961 gaaaagagac ggcgaatatg tgcttgacgg agatccgaca gagggagcgc tgctcaccgc 1513021 ggcaagaaaa ggcggttttt caaaggagtt tgttgaatct aattacagag tgattgaaga 1513081 atttccgttt gattccgcac ggaaaatgat gactgtcatc gtagagaatc aagacagaaa 1513141 gcgctatatc attacaaaag gtgcgccgga tgtactcatg cagcgatctt cccgtattta 1513201 ttatgatggc tcagcggctc ttttttcaaa tgaaagaaaa gcagaaacag aggcggtatt 1513261 aagacatttg gcatcacagg cgctcagaac gatagcggtc gcctacaggc cgataaaagc 1513321 aggcgaaaca ccgtcaatgg agcaggcgga aaaagatctg accatgcttg gcctttcagg 1513381 tatcattgat cccccgcggc cggaagtcag acaggcgatt aaagaatgcc gtgaagcggg 1513441 aattaagacc gtcatgatta caggtgatca tgtagaaacc gctaaagcga tagcgaaaga 1513501 cttgcgcctc cttccgaaaa gcggcaaaat catggacggc aagatgctga atgaactttc 1513561 tcaagaagag ctttctcatg tggtggagga tgtgtatgta tttgcccgcg tttcccctga 1513621 acataaacta aaaatcgtaa aagcctatca ggagaacggg catattgtgg cgatgacggg 1513681 agacggcgtc aatgatgctc ctgccattaa acaggctgat atcggcgtct ctatgggcat 1513741 taccgggaca gatgtggcca aagaagcatc atctcttgtt ctcgtggatg ataattttgc 1513801 gacgattaaa tcagcgataa aagaaggcag gaacatctac gaaaatatca ggaagtttat 1513861 cagatacctg ttggcgtcta acgtcggaga aatccttgtc atgctgtttg cgatgctgct 1513921 tgcccttcct ttaccgctgg ttccgattca gattttgtgg gtcaacttgg tgacggacgg 1513981 attgccggca atggcgctcg gcatggatca gccggaagga gacgtcatga agcgcaagcc 1514041 ccgtcatccg aaagaagggg tatttgcccg caagctagga tggaaggtcg tttccagagg 1514101 atttttaatc ggagttgcca ctattttagc gtttatcatt gtgtaccacc gcaatccgga 1514161 aaacttggct tatgcccaga cgatcgcgtt tgccacattg gtgctcgctc agcttattca 1514221 cgtgtttgac tgccgcagcg aaacttctgt tttctctaga aatccgtttc aaaacctgta 1514281 tttaatcggc gcggtattgt catccatttt gctgatgctt gtagtaatct actatccgcc 1514341 gcttcagccg attttccata ctgtagccat cacgccgggg gactggatgc tcgtcatcgg 1514401 tatgtccgcc atccctactt ttttgctggc ggggtcactt ttaacaagaa aaaaataaat 1514461 tcatatgata taatcttagg ggtaatagcg tgtctattgc ccttttatta tgagaacagg 1514521 gaagaattgg gtgttttaaa atgatacgaa gtatgacagg cttcggcagt gcaagcaaaa 1514581 cacaagacga tctctctgta agcgttgaac ttaaatctgt gaactacaga tttaaagaag 1514641 tgaacgctcg tttgccaagg cctttgctat attttgaaga taagctgaaa cagaccattc 1514701 tgcagcatat tcagcgcgga agaattgagc ttttcgtatc cgttgacagc gatatgcttg 1514761 ttgagaaaag gcttgaaatt gattggccgc tgctcgatga gtttgtcgca gccgcgagag 1514821 atatgaagaa gcggtatcaa ttgtctgcag agcccgatgt aatggatttc tttaagcttg 1514881 atcatgtcgt ccaggttcat gaagaacaga cgcaaaatga caagctggag gcgttgatca 1514941 tcgatgctgc agaagaagcg gtaaaaggtc tctgtgaaat gcgtgaaaaa gaggggctgc 1515001 tcttagcgaa agactgcctg atgcatattg atcagcttga agagctggtg agagaaactg 1515061 aattgctggc tgcagatgtc gtatctcgtt accgggaacg gctgtatgcc agaatcaaag 1515121 aatggactga agacgtatta gacgagagcc ggcttgtaac agaatgcgct atttttgcag 1515181 accgctctga tatcactgaa gagattacaa ggctgaagag ccacttcgcc cagtttcgtg 1515241 atatattagc tagtggcgga gctgtcgggc gcaaactcga ctttcttgtt caggagctca 1515301 atcgggaagc aaatacgatc ggctcaaaag caaatgatca tcagatcaca aagcttgtcg 1515361 ttgaaatgaa aagttctatt gaaaaaataa aagaacaagt gcaaaatata gaatagtgac 1515421 tgtgcgtatt gtttacagac ggtcttacta ggctaaacta gagacgtcta ttttacaggg 1515481 ggaacgtaga agatgacgat taaactgatt aatatcggat ttggcaatat catctccgcc 1515541 aatcggatga tttcgattgt cagcccggag tctgcgccaa tcaaacggat gattcaggat 1515601 gcaagagacc gcggaatgct aattgacgct acatacggac gaagaacccg tgcagttgtc 1515661 gtcatggata gtgatcacat tatcttatct gccgtccagc ctgagacagt tgcacacaga 1515721 ctttctgtta aagaagaaat tatggatgaa gggcaggggt aattgccgca tgaaagaaag 1515781 agggttatta atcgttctct caggtccctc aggagttggt aaaggaacgg ttcgacaagc 1515841 gatcttttcg caggaagaca caaaatttga atattcgatt tcagtaacca caagaagtcc 1515901 aagagagggc gaagtgaacg gagtcgatta ttttttcaaa acaagagacg aattcgagca 1515961 aatgattgcg gacaacaagc tgcttgaatg ggcagagtat gtcggcaatt attacggcac 1516021 gccagtcgat tatgttgaac agacgcttca agatggaaaa gacgtctttt tagaaattga 1516081 agttcaaggg gctcttcaag tgagaaatgc tttcccggaa ggcctgttta ttttccttgc 1516141 gcctccaagc ctttctgaac tgaaaaacag aatcgtgaca cgaggaacag aaacagacgc 1516201 tctgattgaa aatcgaatga aagccgcaaa agctgagatc gaaatgatgg atgcttatga 1516261 ctatgtcgtt gaaaacgata atgtcgaaac ggcttgcgat aaaatcaaag caatcgttct 1516321 tgctgaacat ttgaagcgtg aacgcgttgc accaagatat aagaaaatgc tggaggttga 1516381 ataatcaatg ttagatccgt caattgattc tttaatgaat aaattagatt caaaatatac 1516441 gctggtgact gtttctgcga gacgtgcccg tgaaatgcaa atcaaaaaag accaaatgat 1516501 tgaacatacg atttcacaca aatatgtagg caaagcttta gaagaaattg atgcaggcct 1516561 gctttcgttt gaaaaggaag accgcgaata gtagcacaag tagcaaccta tatcatgtag 1516621 gttgttattt ttttccgtgc ggttttgtaa agtgcagagg gggagaattc attgcttaac 1516681 aatcgaaatg tgttactttg cgtgagtgga ggcatcgctg tttataaagc ctgtgcgtta 1516741 acgagcaagc tggttcaggc aggagcaaat gtcaaagtga ttatgactga atccgcttgc 1516801 cgattcgttt caccgctgac atttcaggca ttgagccgcc acgaagtcta tacagataca 1516861 tttaaagaac aaaatccaag cgtcatttct catattgatg ccgcagactg ggccgacttg 1516921 attatcgtag cgccggctac ggctaatgtg attggaaaac tggcaaacgg catcgctgat 1516981 gatatgctga cgacaacatt gttggcagca acggctcccg tttggatcgc gccggcaatg 1517041 aacgttcata tgtatgacca cccggcagtc aaacgaaaca tttctgttct ttatcaggac 1517101 ggttattgtt ttattgagcc aagtgagggc tatttagcat gcggttacgt aggaaaaggc 1517161 agattggaag agccggaaaa catcgtaaag ctggccgaaa aacattttgc tgaagaaaca 1517221 tccgctcctt tagaaggcaa gcatgtggtc attacagccg gcccaacgcg ggaagcgatt 1517281 gatcctgtcc ggttttttac caataaatcg acgggcaaaa tgggctacgc actggcggag 1517341 gctgctgttc agctcggcgc acgggtaatc ttaatttctg ggcctgtttc acttgatcag 1517401 cctaaaggcc ttgctgagtt tatccctgtt caatcggctg cggatatgcg cgaagctgtg 1517461 ctctctgtgt atgacgcaag cgatatagtc attaaaacag ctgcggtagc cgattttacg 1517521 ccgaaaacag tatttgacca taaaatgaaa aaacaagacg gcggcatgac cttagaactg 1517581 aaaagaacag tcgatatttt gaaagaattg ggcgagaaaa agaaagagca gattttggtc 1517641 ggatttgccg ccgaaacaca agacattgaa cactatgcac gtaaaaagct cgccgctaaa 1517701 aaccttgatt tgattgtggc aaatgatgtg aaagcaaatg gggccggttt tggtgctgat 1517761 acgaatatcg tgacaatctt tttcaaagac gggcataaac gcgaactccc gattatgtct 1517821 aagctcgatg tttcttttga aatccttcag gagatcgcag ccctctcaaa acaaaccgga 1517881 gagcgctcat gaattttgca gaagtcatcg ttgatgtcag caccaaaaat atagacaggc 1517941 cttttgatta taaaatccca gaccatctga agggcatgat caaaacgggg atgcgggtca 1518001 ttgttccgtt tggcccccgt aagattcaag ggtttgtgac agcagtcaaa gaagcatctg 1518061 acctatcggg aaaatctgtc aaggaagtag aggatttatt agatcttaca cctgttctga 1518121 cagaggagct tatgattctg tcatcatggc tgtcagacaa aacgctgtct tttaaaataa 1518181 cggcgcttca agcaatgctg cctgccgcct taaaggcgaa atatgaaaaa gaattaaaaa 1518241 ttgcacacgg agccgatctt ccgccgcaag tggaacggct gttttctgaa acaaagacgc 1518301 tgctgtattc agatataccc gatcatgaga cgctgaaact gattcaaagg catgttcaaa 1518361 aaggggacat tgacgtgacg tataaagtcg cgcaaaaaac caataaaaaa atggtcaggc 1518421 atattcaggc aaatgcgagt aaagaagagc ttgctaagca ggctgaggga ttgtcccgcc 1518481 aagcagcaaa acagcaggcg attcttcact ttctcatctc tgagccggaa ggtgtgaaaa 1518541 ttcctgcggc ggaattgtgc aaaaaaacgg acacgagctc tgcaaccatc aaaaccctta 1518601 tccaaaaagg gcttttgaag gaaagctatg aagaggttta cagagatccc tatcaggaca 1518661 aaatgttcaa aaaaacagag cccctgccgc tgacagacga acagagggct gccttcgagc 1518721 ccatacgcga gacattggac agcgatgagc ataaagtgtt cctccttcac ggcgtgacag 1518781 gaagcggaaa aaccgaaatt tatctgcaat caattgaaaa agtactggcg aaaggaaaag 1518841 aagccatcgt cctcgtaccg gaaatatcgc tgacgccgca aatggtcaac cgcttcaagg 1518901 gccgcttcgg ctcccaggtg gcagtcatgc acagcggttt atccacagga gaaaaatatg 1518961 acgagtggcg taaaatccac cggaaggaag tacggcttgt cgtcggtgcc agatccgcca 1519021 tttttgctcc gtttgaaaat ctcggaatga taatcatcga tgaagagcac gagtcttcct 1519081 ataaacagga agaaatgccg cgctatcatg cgaaagaggt ggcaatcaag cgggctgagc 1519141 atcacagctg cccggttgta ttagggagtg ctacgccgac attagaatca tatgctagag 1519201 cgcaaaaggg cgtatacgag cttctttcac tgaagcaccg tgttaaccat cgggtgatgc 1519261 ccgaggtttc gcttgtcgat atgagagagg agcttagaaa cggcaatcgc tcgatgtttt 1519321 cagttgaatt gatggaaaag cttgaagaaa cgattgccaa gggtgagcag gcggtgctgt 1519381 ttttaaataa gaggggctac tcttcctttg tgatgtgcag ggattgcggc tatgtcccgc 1519441 aatgcccgca ctgcgacatt tccatgacgt atcatcgtta cggccaaagg ctgaaatgcc 1519501 attattgcgg acatgaagag cctgttccgc acacttgtcc tgaatgcgca agcgagcata 1519561 tccgcttttt cggaacggga acacagcgag tggaggaaga gctgacaaaa gtgctgccaa 1519621 gtgcgagagt gattcggatg gatgttgaca cgacatcacg gaaaggcgcc catgaaaaat 1519681 tactgtcagc tttcggagaa ggaaaagcgg atattcttct cggaacgcaa atgatcgcga 1519741 aagggcttga ttttccgaat gtcacgcttg tcggagtgtt aagtgctgat acaacacttc 1519801 atattcctga tttcagatcg gctgaaaaaa catttcagct gttaacgcaa gtcagcggcc 1519861 gggcaggcag gcatgaaaag cccggccatg tcatcattca aacgtataca ccgtctcatt 1519921 acagtatcca gctgacgaaa acacacgatt atgaaacgtt ctatcagcat gaaatggcgc 1519981 acaggagaga gcaatcctat ccgccatact actatttggc tcttgtgact gtttctcatg 1520041 aggaagtggc gaaagcagcg gttacagctg aaaaaatcgc tcattttttg aaagcaaact 1520101 gcggagctga cacgaaaatt ctcggaccaa gcgcgtcgcc gatagccagg atcaaagata 1520161 gatatcgcta tcaatgcgtg ataaaataca aacaggaaac ccagttatcc gctttattga 1520221 agaagatact ggaacattat aaacgcgaaa ttgaacaaaa acatgtaatg atttcaattg 1520281 atatgaatcc ttatatgatg atgtaagatc tcacgtcttg gagggtaaca aattggcagt 1520341 aaaaaaggtc gtcacacatc ctgcggaggt tttggaaaca cctgcggaaa ccgtgactgt 1520401 ttttgataaa aagctaaaaa aactgcttga tgatatgtac gacaccatgc ttgaaatgga 1520461 tggtgtcgga ctggcagcgc cgcaaatcgg cattttaaaa agagcggccg tcgtagaaat 1520521 cggggatgac agagggagaa ttgatctcgt taatcctgaa attttagaaa aaagcggcga 1520581 gcaaaccgga attgaaggat gcttgagctt tcctaacgtc tatggtgatg tcacacgtgc 1520641 cgattatgtc aaagtgcgtg cgtttaaccg tcagggaaaa ccgttcattc tggaagcgcg 1520701 aggcttttta gcaagagccg tgcagcatga aatggaccac ttagacggtg tgctgtttac 1520761 atctaaaata agtaaatact atacagaaga tgaactagcg gatatggaag gatgatttga 1520821 tgacgagaat cgtatttatg ggaacgccgg atttttcagt tcctgtttta agaaccctga 1520881 tagaggacgg atatgaagta gtgggggtcg tcacacagcc ggaccgtccg aagggcagaa 1520941 aaaaagtact gacacctcct ccggtaaagg aagaggcatt gcgccacggc atcccggttc 1521001 ttcagccgga aaaagtcaga ttgacagaag aaattgaaaa agtgctggca ttaaagcctg 1521061 acctgattgt aacggcggca ttcggacaaa ttttgcctaa agagcttctc gacagtccaa 1521121 aatacggctg cattaacgtt cacgcatccc ttttgccgga actgcgcggc ggtgctccga 1521181 tccattattc cattctgcag ggaaagaaga aaaccgggat taccattatg tatatggtag 1521241 aaaaattgga tgcgggcgat atgatctcaa aagtggaagt ggacattgaa gaaaccgaca 1521301 atgtcggaac actgcacgat aaattaagcg ttgctggcgc gaagctattg tctgaaacgg 1521361 ttccaaacgt tattgccggc agcatatcac ctgaaaagca ggatgaagag aaagcgacgt 1521421 acgcgcctaa cattaaaaga gagcaagagc tgctcgactg gtccagaacg ggcgaagagc 1521481 tttacaacca gatccgcggc ttaaatccat ggcctgttgc ttatacgact ctaaacggac 1521541 aaaacttgaa aatatgggcg tcgaaaaaaa tagcggcacc aacaacagct gagcccggca 1521601 cagtcgttgc agttgaaaag gaaggaatta tcgttgccac aggtaacgag acggctctgt 1521661 tattaaccga actccagccg gcaggcaaaa aacgaatgaa aggcgaagac tttgtgcgag 1521721 gcgctcatgt tgaagccggt gatgtgttag gagtaaacaa tgaaaaaaac tagtgttcgt 1521781 gacatcgccc ttgaggcgct gatcaaatta gaacaaaacc aggcatacag caacctgctg 1521841 ctgaaatcgg tcattaaatc aaatgaactg agtgatcaga acagagggct tttgactgaa 1521901 cttgtctatg gtacattaca aaataagatc gcgcttgatt atatgcttaa accgtttatc 1521961 aataagcctc aaaaggtaaa gccgtgggtg attcagcttc ttcgcctatc cttatatcaa 1522021 atggagtatt tggagaagat tccagacagg gcagccattc atgaagcggt tgagattgct 1522081 aaaatccgcg gacacaaagg cattgcttca tttgtcaacg gcgtgctccg ttctattcag 1522141 cgcgaaggtg ttccatcctt tgacgcgatc gaagatcctg tccgccggct ggcgacagaa 1522201 acaagccatc cggaatggct tgtgaaagag tgggcggatg cgtatggatt tgaagctgcg 1522261 gaaaagattt gccgcatcca tctcattccg ccgaaacaga cgctgcgtgt caatcaaatg 1522321 aaagcagaca gagctgagct gcttgaccaa atggctgctg agggaatcga agttgaaaaa 1522381 ggcgacctcg ctgaagatgc tgtgaagctc ttaaagggaa caattgccgg aactcatttc 1522441 ttccaaaacg gcgaagtttc tatccaggat gagagctcca tgctcgtcgc ccgcgccctt 1522501 gatcctaagt cagatgaaac agtgcttgac gcgtgtgcgg cgcctggcgg aaagtcggct 1522561 catatcgcag aattaatgaa gaacaagggg agcgttacgt cgcttgatct tcacaaacat 1522621 aaagtgaagc tgatcaaaga agcggcagat cggcttggcc tgacaatcat tcatgcggaa 1522681 acaatggatg ctagaaaagc gggggaaacg tttgaaaacg aacagtttga ccgaatattg 1522741 gtcgatgccc cgtgctcagg tttcggtgtt atcagaagaa agccggacat gaaatacacg 1522801 aaaaaacctg acgacagcgc ccgtctagct gaaatccagc tgtcgatctt gagggaaatc 1522861 gcaccattag taaaaaaagg tggcactctt gtctacagta cgtgtacaat ggaccggaca 1522921 gaaaatgatg aagtaataca tgcgtttata caagaacatc ctgattttga acccgatttg 1522981 tctcttgaaa agcggctgcc tgaaaaggtg agaccctttg ttcgggatgg aaggcttcaa 1523041 atccttcctc attatttcgg aacagatggt ttctttattt gcagcatgag aaagaaggga 1523101 taagcaatgg cagaacttaa taaaacaaaa gtaagaaaag aattgcggac agagcgtccg 1523161 tctatttatt cttttgaatt agatgaaatc aaacaatggc tgacagacaa tggagagaaa 1523221 ccgttccgtg cagcccagat ctttgaatgg ctatatgaaa aacgcgtatc ttcttttgaa 1523281 gatatgacaa acctctcaaa ggatctgcgt gagaaattaa acactcgctt tgtgttaaca 1523341 acgctgaaaa cggctgttaa acaaacctct caagacggta cgatgaagtt tttgtttgag 1523401 cttcatgacg gttataccat cgaaaccgtt ttaatgagac acgagtatgg caattctgta 1523461 tgtgtaacga cacaagtcgg ctgccgtatt ggctgcacat tctgcgcgtc aacgcttgga 1523521 ggcttaaaac gaaaccttga agcaggggaa attgtcgctc aagtagtcaa agtgcaaaaa 1523581 gctcttgatg aaacggatga acgcgtcagc tctgtcgtga tcatgggaat cggcgaacct 1523641 tttgataact ttaacgaaat gctcgctttc ttgaaaatca ttaaccatga caagggcctg 1523701 aatatcggtg ctcgccatat tacggtctct acgagtggaa tcatcccgaa aatttacgaa 1523761 tttgctgatc agcaaatgca gattaacttt gcaatttctc tgcacgcgcc gaacacagaa 1523821 atcagaagcc gtttgatgcc gattaacaga gcatataaac tgcctgatct aatggaagcc 1523881 gttaaatatt atattaataa aacaggacgc cgtatcagct ttgaatacgg gctgttcgga 1523941 ggcgtaaacg accaggtgga acacgccgaa gagcttgccg acttgctgga aggagtcaaa 1524001 tgccacgtga acttgattcc ggtaaactac gtgcctgaac gggactatgt gcgcacaccg 1524061 cgtgatcaga tttttgcttt tgaaaaaacg ctgaaatccc gcggagtaaa tgtcacaatc 1524121 cgaagagagc aaggacatga cattgacgca gcctgcggtc agcttcgcgc gaaggagcgt 1524181 caagacgaga cgaggtgatg agggttgtta acagccttaa aaacagatac aggaaaaatc 1524241 cgccagcata atgaagatga tgcggggata ttcaagggga aagatgaatt tatattagcg 1524301 gttgtcgctg atggcatggg cggccatctt gctggagatg ttgcgagcaa gatggctgtg 1524361 aaagccatgg gggagaaatg gaatgaagca gagacgattc caactgcgcc ctcggaatgt 1524421 gaaaaatggc tcattgaaca gattctatcg gtaaacagca aaatatacga tcacgctcaa 1524481 gcccacgaag aatgccaagg catggggacg acgattgtat gtgcactttt tacggggaaa 1524541 acggtttctg ttgcccatat cggagacagc agatgctatt tgcttcagga cgatgatttc 1524601 gttcaagtga cagaagacca ttcgcttgta aatgaactgg ttcgcactgg agagatttcc 1524661 agagaagacg ctgaacatca tccgcgaaaa aatgtgttga cgaaggcgct tggaacagac 1524721 cagttagtca gtattgacac ccgttccttt gatatagaac ccggagacaa actgcttcta 1524781 tgttctgacg gactgacaaa taaagtggaa ggcactgagt taaaagacat cctgcaaagc 1524841 gattcagctc ctcaggaaaa agtaaacctg cttgtggaca aagccaatca gaatggcgga 1524901 gaagacaaca ttacagcagt tttgcttgag cttgctttac aagttgaaga gggtgaagat 1524961 cagtgctaat cggcaagcgg atcagcgggc gttaccaaat tctccgcgtc ataggcggcg 1525021 ggggaatggc caacgtgtat ttagctgagg atatcattct agaccgtgaa gtcgcaatta 1525081 aaatcctgcg gtttgactat gcaaatgaca atgaatttat cagacgtttc cgcagagaag 1525141 cccaatccgc atcaagcctc gatcacccga atattgtcag catttatgat ttgggcgagg 1525201 aagatgatat ttattatatt gtcatggaat acgttgaagg catgacgctt aaagaataca 1525261 taacagcaaa tgggccgctt caccctaaag aagcgctgaa catcatggag caaattgtct 1525321 cagccatcgc tcatgcccat caaaaccaga ttgttcacag agacatcaag ccgcataaca 1525381 ttttgattga tcatatggga aatatcaaag taacggattt tggaattgcg acggcactaa 1525441 gttcgaccac aatcacccat accaattcag ttctgggctc ggtccattac ttatcacctg 1525501 aacaggcccg gggcggctta gccacaaaaa aatcggatat ttatgcgctt ggaatcgttc 1525561 tatttgagct tttaaccggc cgtattccgt ttgatggaga gtcagcagtc agcatcgcct 1525621 tgaagcatct tcaagcggaa actccttcgg caaaaaggtg gaatccatcg gtcccccaaa 1525681 gcgttgaaaa catcatactc aaggcaactg ccaaagatcc ttttcatcgc tacgaaacgg 1525741 ctgaagacat ggaagcagac ataaaaacag cttttgatgc cgacagactc aatgaaaaga 1525801 gatttacgat tcaagaagat gaagaaatga caaaagcgat acctatcatt aaagatgaag 1525861 aacttgctaa agctgctggc gaaaaagaag ctgaagtgac aaccgcacaa gaaaacaaaa 1525921 caaagaagaa cggcaaaaga aaaaagtggc cgtgggtttt gctcacgata tgcctcgttt 1525981 ttatcacagc tggaattctt gctgtcactg tttttccgtc gcttttcatg cctaaggatg 1526041 tcaaaatacc tgatgtctcc ggaatggaat acgaaaaagc cgcagggctc ttggaaaaag 1526101 aaggtttaca ggttgattcc gaggtgttgg aaatctcaga tgaaaaaatt gaagagggcc 1526161 tgatggtaaa aacggatcct aaagcggata ccacagtcaa agaaggcgcc acggtcaccc 1526221 tttataagag caccggaaaa gcaaaaacgg agatcggtga tgtgacaggc caaacggtcg 1526281 accaagcaaa aaaagcgttg aaggaccaag ggtttaatca tgtaacagta aatgaagtga 1526341 atgacgagaa aaatgcgggc actgtcattg accaaaatcc ttcagcaggg actgagctgg 1526401 tcccgagtga agatcaagtc aaacttacag tcagtatcgg acccgaagac attacgctta 1526461 gagacttgaa aacctacagt aaagaagcag cgtctggata tctggaagac aacggattga 1526521 agcttgtaga aaaagaagca tactcagatg atgttccaga aggacaggtt gtcaaacaaa 1526581 aaccagcagc aggtacggca gtaaagccgg gaaacgaagt tgaagtgaca ttctctctcg 1526641 gaccagagaa aaaacctgcg aaaacagtga aagaaaaggt caagatcccc tacgaaccag 1526701 aaaatgaagg ggacgagctt caagtgcaaa tcgcggttga cgatgcggat cacagcatct 1526761 ctgacactta cgaagaattt aagataaaag agccgactga acgaacgatc gaactaaaga 1526821 ttgaaccagg ccaaaaaggg tactatcaag taatggtaaa caataaagtt gtcagctaca 1526881 aaaccattga gtatccgaaa gatgaataac aaggagggaa aatatgcctg agggcaaaat 1526941 tattaaggcg ctaagcggct tttactatgt actggatgaa tcagaggatt cagataaagt 1527001 aatacaatgc agaggaagag gcattttcag aaaaaacaaa attacccctc ttgtcggtga 1527061 ttacgttgtg tatcaagctg aaaatgacaa agaaggatat ctaatggaaa ttaaagaaag 1527121 aaccaacgag cttatcaggc cgccaatttg caacgttgat caagcggtcc ttgttttctc 1527181 agcggttcag ccttctttca gcacggcatt gctcgaccgc ttcctggttc tcgttgaggc 1527241 caatgatatt cagccgatta tatgcattac taaaatggat ctgattgaag atcaagatac 1527301 agaagatacg atacaagcct atgcagaaga ctatcggaat attggttatg acgtatacct 1527361 tacctcctct aaggaccaag atagtttagc ggacatcatc ccgcattttc aggataaaac 1527421 aacggtattt gccggtcagt ccggtgttgg gaaatcctcg cttctcaacg cgatcagtcc 1527481 ggagctcgga ttaagaacaa acgagatttc cgagcatttg ggccgcggga aacacacaac 1527541 ccgccacgtg gagctgattc acacgtccgg aggtttggtt gcagatacac cgggattcag 1527601 ctcgcttgaa tttacagaca ttgaggaaga agagctgggc tataccttcc ctgatatcag 1527661 agaaaaaagc tcttcatgca aatttagagg ctgtttacat ctgaaagagc cgaaatgtgc 1527721 ggtgaaacaa gctgttgaag acggggaatt aaagcagtat cgctatgacc attatgttga 1527781 atttatgacg gagattaaag acagaaagcc gaggtattag cataatgata aaggttgcac 1527841 catctattct ttccgctgat tttgccgctt taggcaatga gattaaagat gtagaaaaag 1527901 gcggagccga ttgtattcat attgatgtta tggacggcca ttttgtcccg aatatcacaa 1527961 tcggtccgct gattgtagaa gcggtccggc cggtaacgga tctgccgctt gatgtccatt 1528021 taatgataga agagccggat cgttatatcc cggcttttgc gaaagcaggc gcagatatcc 1528081 tgtctgtgca tgctgaggca tgtccgcacc tgcaccgtac catccagctc attaaagagc 1528141 aaggagtgaa ggccggagta gttctaaacc cgcatacccc tgtacaagtc atcgaacatg 1528201 ttttcgacga tcttgatctt gttcttttaa tgacggtgaa cccgggcttc ggcgggcaga 1528261 aatttattca ttcagtcctt cctaaaataa aagaggttaa gcgaatggcg gatgaaaaag 1528321 gaaaaaaaga tctgttaatt gaagtagacg gcggcgtcaa caaagaaacc gctccgctcg 1528381 tcattgaagc gggcgcaaat ttactcgttg ccggttcagc tgtttatggc cagtctgacc 1528441 gcaaaaaagc aatttctgaa atcagaggaa gtaaataagc agctttagaa aagagctggg 1528501 catacaatag cctaagctct ttttcctgta tgcagagaaa ggaatcagag atgaaaacaa 1528561 ttaatatcgt tgcgggaggc ccgaaaaatc tcattcccga tctaaccggc tatacggatg 1528621 aacacacgct ttggatcggt gttgacaaag gcaccgtcac tctcttagat gccgggatca 1528681 ttcctgttga agccttcgga gattttgaca gcataacgga gcaagaacgc cggcgaatag 1528741 aaaaagccgc tcccgccctt catgtgtatc aagcagaaaa agatcaaaca gatttagacc 1528801 tcgcccttga ttgggcgctg gaaaagcagc cggatattat tcagattttc ggcattacag 1528861 gcggcagagc tgatcatttt ttaggaaaca ttcagcttct gtataaaggt gtaaaaacga 1528921 acataaaaat taggctgata gacaaacaaa atcatattca aatgttccct cctggtgaat 1528981 atgatattga gaaggatgaa aataagcgat atatctcctt cataccgttt tccgaagaca 1529041 tacatgagct gaccctgacc ggttttaaat atcctctaaa taattgtcat attacgctcg 1529101 gttcaacact atgtattagt aacgaactca ttcattcacg aggtactttt tcgtttgcaa 1529161 aaggcatatt aataatgata agaagcacgg attaagcatg tgctttcatt caattgctga 1529221 aaacaatgaa caaggcggtt acgggacgtt ataggagggg acaaaaatga aattttacac 1529281 cattaaattg ccgaagtttt taggaggaat tgtccgggcg atgctgggct catttagaaa 1529341 agattaatgc ccaggggttc aaagccctct ttcaccacat aaaaacgcct gccacatatc 1529401 ggggcaggcg ttcattttgt tatacacgct caactttacc ggatttcaaa gctcgagcag 1529461 atacatatac ttttttaggt tttccgttca caaggatacg aaccttttga agattcgcgc 1529521 cccaagtgcg cttagaagcg ttcattgcgt gagaacggtt attcccagct gttgtttttt 1529581 tacctgtgat aacgcattta cgtgccattt gtttccctcc tcacttgcac aaaacatcta 1529641 ctttttaaca ttcatataat cttagatgct ttcgatatgg atactttaaa taatttacca 1529701 cagctaaaaa acgtttgcaa ctattgtttc atcatctttc aagaaaattc acttgacatc 1529761 ttgcggaaac agcagcgcta tagtatatgt agaggtacgg ccagcgatta ttgcctggtc 1529821 ttttcataat ggaaaccata tagtagaata gctgtaactc tatgcattcg aaggaggaac 1529881 tagtgtgtcc attgaattaa gaacgaagta cggacagatt gatatatcta atgaagtcat 1529941 cgcgatggtt gcaggaggcg cggcggttga ctgttacggc attgtcggca tggcctctaa 1530001 aaaccagatt aaagacggac tgactgaaat ccttcggaaa gagaatttca gcaggggtgt 1530061 ccaagttcgc caagaaggag aacagataca tatcgacatg tatatcattg tcagctacgg 1530121 cacgaaaatt tctgaagtgg cacataatgt ccaaacaaaa gtaaagtaca cagtaaatca 1530181 aaccatcgga ctggcagtgg attctgtcaa tatttatgtc caaggcgtac gagtgacgaa 1530241 cccgtagtta ggaggagtag gattgtctat cagaacatta gacggcagaa cctttgccga 1530301 gatgattctt gcgggagcgc agaatctgtc tcaaaacgcc agtgcagttg atgcactgaa 1530361 cgtgttcccg gtgccggacg gtgatacggg aacaaatatg aacctgtcga tgacttccgg 1530421 agcaagagaa gttgaacaaa tggatacgga tgatatcggg aaggtgggct ccgcgttatc 1530481 taaagggctg ctcatgggag cacgcggaaa ttcaggagtt atcctatccc aattgttccg 1530541 cggatttagc aaaaacattg aaacgaaaaa agaaattaat gcacttgagt ttgccgctgc 1530601 gctgcaagca ggtgtagaca tggcgtataa agctgtcatg aaacctgtag agggcaccat 1530661 tttaacagtt gcaaaagacg ctgcaaaaaa agcaatgatc ttagcagaaa aagaaaccga 1530721 tatcactgcg ctgatgactg cagtgacaga agaagcagag gcgtctttaa accgcacccc 1530781 tgaattgcta cctgtcctaa aggaagtagg agttgtcgat agcgggggca aaggcctgct 1530841 ctgtgtgtat gaaggtttcc ttgcttcatt aaaaggtgaa actgtacctc agaaagcagt 1530901 tcttccgtca cttgacgaca tggtcagcgc agagcatcac aagagcgcgc aaagcatgat 1530961 gaataccgaa gatattgaat ttggattctg taccgaagtg atggttaggc ttgatcagac 1531021 aaaaagagag ttcgacgaag gcacgttcag gcaagacctc agccagttcg gagattctct 1531081 gcttgtgatt gcggatgaat cgctggcgaa ggttcatatt catgctgaag agccgggaaa 1531141 cgtgttaaac tacgcccagc attacggtga attgatcaaa ataaaaatag aaaatatgag 1531201 agaacagcat acctctatca tcagtcaaga aagcaaacct gcagacaacg aaacaccgcc 1531261 ggcaaaacag ccgtatggca ttgtgactgt agcgatggga gaaggaattg cagacctatt 1531321 taaaagcatt ggcgcttctg ttgtgattga aggcggccag accatgaacc caagcactga 1531381 ggatattgtt gatgccgtga agtctgtaaa tgcagatacg gtatttatcc tgcctaacaa 1531441 ctccaacatt atcatggctg ctaaccaagc ggccagcgta gtggatgaac aggtttttgt 1531501 cattcctgct aaaacggttc cgcaagggat gtcagctctg ctggctttta acccggatca 1531561 agaagctgaa gcgaacgagg ccaatatgct aagcgccatt cagcaagtaa aaagcggaca 1531621 ggtgacgttc tcagtcagag atactcatat tgacggtaaa gacattaaaa aaggcgactt 1531681 tatgggcatt ctgaatggaa cgattatcgg cacttctgaa aatcagctgt cagccgcgaa 1531741 aatgctgctg tcagaaatga tcggagaaga tgatgaaatc gtgaccattc tatatggtga 1531801 ggatgcgtct caggaagaag ctgagcagct tgaagcgttt ctcagtgaaa agtacgagga 1531861 gattgaggtt gagatccaca atgggaaaca gcctctgtat tcgtatatag tttcagcaga 1531921 atagaagggc aatttgccct tctattctta tgtctgcttt taagtgcggc agcgctgtaa 1531981 cgcgcccgct tgccatttta tatctgatca attagtctag aagcaaagcg ctaataagct 1532041 ctggttcata aggaggaata gcatgaaata cagaagcgtt tttgatatta tcggcccggt 1532101 tatgatcggt ccgtccagct ctcatacagc gggagctgct agaatcggga gagtggccag 1532161 aagtttattt ggcagagagc ctgagcgcat cattgtatct ttttacggct cgtttgcgga 1532221 aacgtataag ggccacggca cagatgtcgc gattatcggc ggattgcttg attttgatac 1532281 attcgatgaa cggattaaaa ccgctataca aattgcagaa gctaaaggaa ttgatataga 1532341 gtttcgggta gaagacgcag tcccggtcca cccgaacaca gcaaaaatca ccatttctga 1532401 tgaaaagggt gagctggaac tgacgggtat ttcgattggc ggaggaaaga ttgaaatcac 1532461 agaattgaat ggttttgagc tccggctgtc aggaaatcat ccggccatat tagttgttca 1532521 taatgacaag tttggcacaa ttgccggtgt tgccaatgtt ctggcgaaat tttcaatcaa 1532581 cgtaggacat atggaagtag cccggaaaga tatcggccag cttgcgctga tgacaataga 1532641 ggtcgatcaa aatattgacg accacattct cgacgagctg tcgaagctgc cgaatattat 1532701 tcaagtgaca aagattgctg actagcgaaa agggtcagga ggagccagtt atgtttcgta 1532761 atgtaaaaga attaattgag attactaaag aaaaacaaat attgatctct gatgtgatga 1532821 tagctcaaga gatggaagta acagaaaaaa caaaagagga catttttcag cagatggatc 1532881 ataacctgtc tgttatggaa gcggcggttc agaaaggact cgagggagtt acgagccaaa 1532941 cgggcttaac aggcggagat gccgttaaat tgcaggccta tattcgatca ggaaaaagcc 1533001 tgtctggccc gctgatttta gatgctgtat cgaaagccgt tgcaacaaat gaagtaaatg 1533061 cagccatggg aaccatctgt gcgacaccga ctgcaggttc tgccggtgtg gtgcccggta 1533121 cgttatttgc tgtaaaagaa aagctgaatc caacaagaga acaaatgatc cgctttttgt 1533181 ttacagccgg ggctttcgga tttgtcgtgg ccaataacgc aagcatttcc ggcgccgccg 1533241 gaggatgtca ggcagaggtt ggatcagctt caggcatggc ggctgcggct attgttgaaa 1533301 tggcaggagg aacacccgaa caaagcgcgg aagccatggc cattacatta aaaaatatgc 1533361 taggcctcgt gtgcgaccct gttgcagggc ttgttgaggt gccttgcgtg aaacggaatg 1533421 cgatgggcgc gtcaaatgcg atgattgctg ctgatatggc attggcgggc attacaagcc 1533481 gtattccatg tgatgaggtt atcgatgcca tgtataaaat aggccaaacg atgccaactg 1533541 cacttagaga aacaggccag ggcggtttag cggcaacacc gacaggaaga gaattagaga 1533601 aaaaaatttt cggaggagcg ctaggttcac gtgaaacaac atcagcaaac tagtatagct 1533661 aacattaagg gtattgggcc ggaaacagaa aaaacattga atgaactcgg tatttatgac 1533721 atttctgatc ttctgaatta tttcccttat cgctatgatg actacgagct gagggattta 1533781 gaagaagtaa agcatgatga aagagtcaca gtcgaaggga aggttcattc agagccttct 1533841 cttacctatt acggaaaaaa acgaaacagg ctgacattca ggcttctggt cggccactat 1533901 ttaatcacag ccgtatgttt taaccggcct tatttgaaga agaagctttc gctcggctct 1533961 gtggtgacgg tttcaggtaa atgggacaag caccgccaaa ccatctctgt tcaggagttg 1534021 aaaaacgggc cgcatcaaga agacaaaagc attgaaccag tgtattctgt gaaagaaaat 1534081 gttaccgtca aaatgatgag gcgctttatt cagcaggcgc tgacccaata tgcagactca 1534141 cttcctgatc ctcttccgga aaagctaaga aaaagctata aactgcctga ctattatcaa 1534201 gcgttaaaag caatgcacca gcctgaaaca agggaagcat taaagcttgc cagacggcgg 1534261 tttgtttatg aagaattttt gttgtttcag ttgaaaatgc aggcgttccg aaaggcggaa 1534321 agagagcaga cacaagggat acggcagcgt ttttcaaacg aagaactcat gagatttatc 1534381 aaaagcctcc cgtttcccct cacaaacgcc cagtcacgcg ttcttcgcga aataacagca 1534441 gacatgtctt ctccatacag aatgaaccgt cttcttcaag gggacgttgg atcaggaaaa 1534501 acggcagtcg ccgccattgc actgtatgcc gcgatcctat ccggatacca aggagcgctc 1534561 atggtgccga cagaaattct ggccgagcag catgctgatt cgctcgtttc gctatttgaa 1534621 aaatgggacg tcagcgttgc tcttttgaca agctctgtta aaggaaagcg gcgaaaagaa 1534681 ctgcttgagc gtcttgcggc gggtgagatt gatattcttg taggaaccca tgctttaatc 1534741 caagacgagg tggagtttaa ggcgttgagt ctcgttatta ctgatgaaca gcacagattt 1534801 ggagttgagc agcgcaaaaa gcttcggaac aaagggcagg atcccgatgt tctctttatg 1534861 acagccactc caatcccaag aacattagcg atcacagtat tcggtgaaat ggatgtatct 1534921 gtcattgatg agatgccggc tggacgaaag cgaattgaaa cctattgggt aaaacatgac 1534981 atgcttgatc gtattttggc atttgtcgaa aaagaattaa agcaaggcag gcaggcttat 1535041 atcatctgtc cgctgattga agaatcagat aagcttgatg tgcaaaacgc cattgacgtg 1535101 tacaatatgc tttctgatat ttttcgggga aaatggaatg tcggccttat gcatggaaag 1535161 ctgcattccg atgaaaaaga tcaggtcatg agagaattca gcgcaaatca ctgtcaaatt 1535221 ctcgtatcaa ccactgttgt ggaggttggc gtaaatgttc cgaatgcaac aattatggtg 1535281 atttatgacg ccgaccgttt cggactatca cagcttcacc agctgcgcgg ccgtgttgga 1535341 cggggtgagc atcaatcttt ctgtattctg atggctgatc caaaatcaga aacagggaaa 1535401 gaacggatga ggatcatgtc ggagaccaat gacggtttcg agctgtctga aaaggatctg 1535461 gaactgagag gtcccggtga tttcttcggg aaaaaacaaa gcggaatgcc ggaatttaaa 1535521 gtggcggaca tggttcatga ttacagagcg cttgaaacgg caaggcagga tgctgcgaat 1535581 cttgtggctt ctgacgcgtt ctggaaggag ccggaatacg ctgtgttaag agatgaattg 1535641 ctgaagagcg gagtaatgga cggggaaaaa ttaagctgag tatcagaagt ttttggtgtt 1535701 cagccagaaa caatcgttgc attccaatct atgaaattat atactactat tagtacctag 1535761 tcttaattgt ccggatggtg tttagatatg agaagaaata agagagaacg ccaggaatta 1535821 cttcagcaga cgattcaagc aacccccttt attacagatg aagaactagc gggtaaattc 1535881 ggggtgagca tccagacgat acgtttggac cgcttagagc tttccatacc tgaactgaga 1535941 gaaagaatta agaacgtggc agagaaaaca cttgaggacg aagtgaagtc cctgtcactt 1536001 gatgaagtta tcggagaaat tattgacctt gagctggatg atcaggcgat atccatttta 1536061 gaaataaaac aggagcacgt gttcagccgg aatcagattg cgagaggaca ccatttattt 1536121 gcacaggcga attctttggc cgttgcagtc attgatgacg agctggcgct gactgcaagt 1536181 gcagacatcc gctttacaag acaggtaaag cagggtgaac gtgtcgtagc aaaagcgaaa 1536241 gtgacggctg tcgaaaaaga aaaaggaaga acggttgtcg aagtgaacag ctacgttggc 1536301 gaagaaattg ttttttctgg acgctttgac atgtatcgtt caaaacattc ataaaggtgg 1536361 agcatgcatg agaatagctg tagatgcaat gggaggagac cacgctccca aagctgttat 1536421 tgacggagtt ataaaaggta tagaggcatt tgatgatctc catatcacac ttgtcggtga 1536481 caaaacaacg atagaatcac atttaacaac tacatcagat cgcatcacgg tgctgcacgc 1536541 agatgaagtg attgagccta cggatgaacc ggtccgtgcc gtgcgaagaa aaaagaactc 1536601 atctatggtt cttatggcgc aggaggttgc ggaaaacaga gctgacgcct gcatttcagc 1536661 gggaaatacc ggtgcattaa tgacagccgg tctctttatt gtcgggagaa ttaaaggaat 1536721 tgaccgtccg gcgcttgctc cgacacttcc gactgtttcg ggagacggat ttcttctcct 1536781 tgatgtcggc gccaatgtcg atgccaaacc ggagcacctc gttcaatatg ccatcatggg 1536841 ttctgtttat tctcagcaag tgcgcggtgt cacttcaccg agagtcggac ttttaaatgt 1536901 cggaacagaa gataaaaaag gaaacgaact gacgaagcag acgtttcaaa ttttaaaaga 1536961 aacagcaaac atcaatttta tcggaaacgt ggaagcgcga gaccttttag atgatgtggc 1537021 ggatgttgta gtaacagacg gctttaccgg gaatgttaca ctcaaaacgc tggaaggctc 1537081 tgcgttgtca atttttaaaa tgatgagaga cgtaatgacg tctactttga catccaagct 1537141 tgcagcagct gtgctgaaac caaaattgaa agaaatgaaa atgaaaatgg agtattcgaa 1537201 ttatggcgga gcaagtcttt ttggcttaaa agcgcctgtg atcaaggcgc acggctcttc 1537261 agattcaaat gctgtattcc atgcgattcg gcaagcaaga gagatggtca gccaaaatgt 1537321 ggctgcgctc attcaggaag aagtgaaaga agaaaaaaca gatgagtagt ctggaggttt 1537381 ttacatcatg agtaagattg catttttatt cccgggtcag ggatcacaat ttatcggcat 1537441 gggaaaagag ctttatgagc aggtgcctgc tgcaaagcgt ctgtttgatg aagccgatga 1537501 aacgttggaa acaaaactca gctcgcttat ttttgagggg gatgctgaag aattaacact 1537561 tacatacaat gcgcagcctg ctttgcttac gacaagcatc gctgttcttg agaaatttaa 1537621 agaatctggc attacacctg atttcacagc aggacacagc cttggtgaat attctgcact 1537681 ggttgcggct ggcgctctgt ctttcaaaga tgctgtttat actgtcagaa agcgcggaga 1537741 gtttatgaat gaagcggtgc cggctggcga aggagcaatg gctgcgattc tcggcatgga 1537801 tgctgaagca ttaaagcaag taaccgataa agtcacagag gaaggcaacc ttgtacagct 1537861 tgcgaatctc aactgtcctg gccaaatcgt catttccgga acagctaaag gggttgagct 1537921 tgcatctgaa ctggcaaaag agaacggcgc aaaacgcgca attccgcttg aagtaagcgg 1537981 tccgttccat tctgaactga tgaaaccggc tgctgaaaag ctgaaagagg tattggacgc 1538041 ctgtgacata aaagacgctg acgttccggt catctcaaat gtttctgctg acgtgatgac 1538101 tgaaaaagca gatatcaaag aaaaacttat tgagcagctt tactctccgg ttcgttttga 1538161 ggaaagcatt aacaagctga tcgcagaggg tgttacgact tttattgaaa tcggtcccgg 1538221 aaaagtgctt tcaggccttg tgaaaaaagt gaatagacgg ttaaaaacaa ttgctgtatc 1538281 agatccggaa acgatcgagc tggcaattca aacgcttaag gaggagaatg ataatgctta 1538341 atgataaaac ggctattgtc actggcgcat cccgcggaat cggccgctca atcgcccttg 1538401 atctggcaaa aagcggagca aatgttgtcg tgaactactc cggcaatgaa gcgaaagcaa 1538461 atgaagtggt agatgaaatc aaatcaatgg gcagaaaagc aattgctgta aaagcggatg 1538521 tatcaaatcc cgaagatgta caaaacatga taaaagaaac attgtctgtt ttttctacga 1538581 ttgacattct ggttaataat gcgggaatta caagagacaa tctcatcatg agaatgaaag 1538641 aagacgaatg ggatgacgtc attaacatta acctgaaggg tgttttcaac tgcacaaaag 1538701 ctgttacaag acaaatgatg aaacagcgtt caggccgcat tattaacgta tcgtctatcg 1538761 tcggcgtcag cggaaaccct ggacaagcca actacgtggc tgcaaaagcc ggcgtcatcg 1538821 gtttaaccaa atcttctgct aaagagctcg ccagccgaaa tattacggta aacgcaatag 1538881 cgccaggatt tatctcaact gatatgacag ataaacttgc aaaagacgtt caagacgaaa 1538941 tgctgaaaca aattccgctc gcgcgctttg gtgaacctag cgatgtcagc agtgttgtca 1539001 cgttcctagc ttcagaggga gctcgttata tgacaggcca aacgcttcat attgacggcg 1539061 gaatggtgat gtaagttttt tctcgaaaat ttcatcgtag tttctctagt tttttaaaaa 1539121 cgaatccact ataatacttg aggggaggtg aattgctatg gcagacacat tagagcgtgt 1539181 aacgaaaatc atcgtagatc gccttggcgt tgatgaagca gacgtcaaac ttgaagcttc 1539241 tttcaaggaa gacttaggtg ctgattccct agatgtagtt gagcttgtta tggaacttga 1539301 agacgagttt gatatggaga tttctgacga agatgctgaa aagattgcaa cagtcggcga 1539361 cgctgtgaac tacatacaaa accagcaata agctgatgct aaaagtcccg ccgaaacgcg 1539421 gggctttagc cctttattcg tgcagttatt acagcatgcc gcttttacgc gcgctgtatc 1539481 cggtttagtc agagaagcgc ggtgaacctg atgtgcctat ggaggttact atgtcaaaac 1539541 actcacatta taaagataaa aaaaagttct ataaaaaagt agaacaattt aaagagtttc 1539601 aagaacggat ttcggttcac tttcaaaatg aaaagctttt gtatcaagca tttacacatt 1539661 catcttatgt gaatgagcat cggaaaaagc cgtatgaaga taatgaaagg cttgaatttt 1539721 taggtgacgc tgttttggaa ctgacgatct ccagattctt atttgccaaa tacccggcta 1539781 tgagtgaagg agatttgacg aaattgagag ccgcaattgt ttgcgaaccg tctctcgttt 1539841 cattggctca cgagctgtca ttcggcgatc ttgtcctgtt gggtaaaggc gaggaaatga 1539901 caggcggaag aaagcgtcct gctctattgg cggatgtttt tgaggcattt atcggagcct 1539961 tgtaccttga ccaaggatta gagccggtcg aaagtttctt aaaagtttat gtgttcccta 1540021 aaattaacga tggtgctttt tctcatgtga tggatttcaa aagccagctg caggaatacg 1540081 tgcagcggga cggcaaaggc tctctggagt ataaaatctc caacgaaaaa ggacctgcgc 1540141 acaaccgtga atttgaagcc atcgtatctc taaaaggtga accactcgga gtcggaaacg 1540201 gccgttcaaa gaaagaagcc gaacagcacg ctgctcagga agctttagct aaattgcaaa 1540261 aacaccatac gaaacaataa aatccccctt atgactcagg gggatttcag tatgtatgcc 1540321 gtcttatttg accaatgttt atgatagaat tgaaatactt attacataag gaggatcgct 1540381 atgttcctca aacgtttaga cgttatagga tttaaatcat ttgcagaacg gatttccgta 1540441 gacttcgtta aaggcgtgac agcagttgtc gggccgaacg gaagcggaaa aagcaacatc 1540501 acggatgcca ttcgctgggt tctcggcgaa caatcggcac gctctcttcg cggcggaaaa 1540561 atggaagaca tcatttttgc tgggagtgat tcaagaaagc gattaaatct agctgaagtt 1540621 acgcttactc ttgataatga tgatcatttc ttgccaattg acttccacga ggtgagtgtc 1540681 acaagacgtg tgtacagatc aggtgagagt gagtttctga ttaacaatca gccatgccgc 1540741 ttgaaagata ttattgattt atttatggac tctgggcttg gtaaagaagc attttctatt 1540801 atcagccaag ggaaagtgga agagatcctg agcagcaaag cggaggatcg ccgcagtatc 1540861 tttgaagaag cggccggggt gcttaaatat aaaacgagaa agaaaaaagc agaaaataaa 1540921 ctgtttgaga cacaggacaa tctaaatcgg gtagaagata tattacatga gcttgaagga 1540981 caggttgaac ctcttaaaat tcaagcttca atagcgaaag actaccttga gaaaaagaaa 1541041 gagctggagc atgttgaaat tgcgctgact gcctatgata tcgaagagct gcatggtaaa 1541101 tggtcgactc ttaaagagaa agtgcagatg gcaaaagaag aagagcttgc tgaatcgtct 1541161 gctatttctg cgaaagaagc aaagattgag gatacaaggg acaaaataca agcgcttgat 1541221 gagtcagtag atgagctcca gcaagtttta ctggtaacta gtgaagagct ggaaaagctt 1541281 gaaggccgta aagaagtcct gaaagaacga aagaaaaacg ctgtgcaaaa ccaagaacag 1541341 cttgaagaag ccatcgttca gttccagcaa aaagaaacgg ttctgaaaga agagctttcg 1541401 aagcaggaag ctgtcttcga aacgcttcag gctgaggtga agcagttaag ggcgcaagta 1541461 aaagaaaaac agcaggctct cagtcttcac aatgaaaatg tcgaagagaa aatcgagcag 1541521 ctgaaaagtg attattttga gctgttaaac agccaggctt cgatacgcaa cgaactccag 1541581 cttcttgatg accagatgtc ccaatccgct gtcacattgc agagacttgc ggacaacaat 1541641 gaaaagcacc tgcaggaacg gcatgatatt tctgcgcgta aagccgcatg tgaaacggaa 1541701 tttgcccgaa ttgagcagga gattcacagt caagtcggtg catatcgtga tatgcagaca 1541761 aaatatgagc agaaaaagcg ccaatacgaa aaaaatgaat ccgctctgta tcaggcatac 1541821 caatacgttc agcaagcgag atcaaaaaag gacatgcttg agacgatgca gggagatttc 1541881 tccggctttt atcaaggtgt taaagaagtg ctgaaagcga aagagcgcct tggcggaatt 1541941 cgcggagcgg ttcttgagct gatttctaca gaacagaagt atgaaacggc cattgaaata 1542001 gcgctcggcg cttctgctca acacgtcgtg accgacgatg aacaatctgc ccgcaaagcg 1542061 attcaatatt taaagcagaa ttccttcggc cgggcgacgt ttctgcctct ttctgttatt 1542121 agagaccgcc agcttcaaag ccgtgacgcg gaaacagccg cccggcattc atcatttctc 1542181 ggggttgcca gtgaacttgt cacatttgat cctgcgtatc gaagcgtcat ccagaatctt 1542241 cttggaaccg ttctgatcac agaggactta aagggtgcaa acgagcttgc gaagcttctc 1542301 gggcaccggt accgcatcgt aacccttgag ggagatgttg tgaaccccgg tggttcaatg 1542361 acgggcggcg cggttaaaaa gaaaaataac tccctccttg gaagaagccg ggagctagaa 1542421 gatgtgacga aacggctcgc tgaaatggaa gagaaaacgg cactgcttga acaagaggtc 1542481 aaaaccctta agcactccat tcaggatatg gagaaaaaac tggctgactt aagagaaacc 1542541 ggggaaggct taaggttaaa gcagcaggat gtgaaaggcc agctgtacga acttcaagtt 1542601 gccgagaaaa atatcaatac ccatttagag ctctatgatc aagaaaaatc tgctctgtca 1542661 gaaagcgatg aagagagaaa agtgcgcaaa cgcaagcttg aagaagagct ctctgccgta 1542721 tctgaaaaga tgaaacagct tgaagaggac atagacagac tgacaaaaca aaaacaaacg 1542781 caatcctcaa cgaaagagtc tctctccaac gagctgactg agctgaagat cgcagcggcc 1542841 aaaaaagagc aggcttgcaa gggggaagag gacaaccttg ccagattaaa gaaagagctc 1542901 actgaaacag agcttgcgtt aaaagaagca aaagaagact taagcttctt aacgtcagag 1542961 atgtcatcta gcaccagcgg cgaagaaaag ctggaagaag cagcaaaaca taaattgaat 1543021 gacaaaacga aaacgatcga actgattgca ttaaggcgcg atcagcgcat caagcttcag 1543081 catgggcttg atacgtatga gcgtgagctg aaagaaatga aacgcctgta taaacaaaaa 1543141 acaacgctct taaaagacga agaagtcaaa cttggacgaa tggaagtcga gcttgataat 1543201 ttactccaat acttacggga ggaatacagc ttgtcctttg agggggcaaa agagaaatat 1543261 cagcttgaaa ctgatccaga ggaagccaga aagcgcgtga agctgattaa actcgcaatt 1543321 gaagagctgg gtaccgtgaa cctcggaagc atagatgagt ttgagagggt caacgaacgg 1543381 tacaagtttc tgtcggaaca aaaagaagat ttaacagaag cgaaaaatac cttgttccaa 1543441 gtgattgaag aaatggatga agaaatgacg aagcgcttta acgacacatt cgtccaaatc 1543501 cgctcacact ttgatcaagt tttccgctcc ttattcggag gagggcgagc tgaactgagg 1543561 ctcaccgatc ctaacgatct gcttcattca ggagtcgaga ttatcgctca gccgccgggg 1543621 aaaaagctgc aaaacttaaa cctcctgtca ggcggagagc gtgcgcttac tgctatagcg 1543681 ctcttattct caatcctaaa ggttcgtcca gtgccgtttt gcgtccttga cgaagtagag 1543741 gctgcgctcg acgaagcgaa tgtgttccga tttgcgcagt atttaaaaaa atacagcagc 1543801 gatactcagt ttattgtgat tacccacaga aaaggaacga tggaggaagc ggatgtgctt 1543861 tatggcgtaa ccatgcagga atccggtgtt tccaaggtaa tttcagttaa gctggaagaa 1543921 acaaaagaat tcgttcagta acgaggaaag aggttaaaag atgagctttt ttaaaaaatt 1543981 aaaagagaaa atcacaaaac agacagattc cgtatctgaa aagtttaagg atggccttga 1544041 aaaaacaaga aactcctttc aaaacaaagt gaatgatctt gtatcccgtt accgtaaagt 1544101 ggatgaggat ttcttcgaag agcttgaaga ggttcttatc agcgcggatg tcggttttac 1544161 aaccgttatg gaattaatag atgagctgaa aaaagaagtc aaacgcagaa atattcaaga 1544221 tccaaaggaa gtccagtcag tgatttctga gaaactggtc gagatttata acagcggaga 1544281 tgagcaaatt tcagaactga acatccagga tgggcgttta aacgtaatcc ttctggtagg 1544341 tgtaaacggc gtcgggaaaa caacaacgat cggaaagctt gctcataaaa tgaaacaaga 1544401 aggaaaatct gttgtacttg ccgccggaga cacttttaga gcgggagcca ttgaacagct 1544461 ggaagtatgg ggagagcgta caggagtgcc tgtcattaag cagacggcag gaagcgatcc 1544521 ggcggctgtc atctacgatg ctgttcatgc tgcgaaagca agaaatgccg atgtattaat 1544581 ttgtgatacg gcagggcgtc tccaaaacaa agtaaatctc atgaaagagc ttgaaaaagt 1544641 aaaacgtgtt atcgaaagag aagttcctga agctccgcat gaggtgctgc ttgcccttga 1544701 tgccacgacc ggccaaaatg caatggctca ggcaaaagaa ttctctaaag caacaaatgt 1544761 taccggcatt gctttaacga agcttgacgg tacggcaaaa ggcggtatcg tccttgcgat 1544821 tcgcaacgag cttcacatcc cggttaaact agtcggttta ggagaaaaag ttgatgacct 1544881 tcaggaattt gatccagaat cctatgtgta cggactcttt tcagatttag tggaaaaagc 1544941 cgacgattaa gaaaaaggcc ccaacatctt ggggcctttt tcttttttat cttcttactt 1545001 gataggcgaa atgataaagg ctgttatcag tggataccag tcttgactca ccagaaaaaa 1545061 ctctgaatgg gatgatgtca tagtaatgaa cggaaacaga tgtgtaatac gtatagtaac 1545121 cagcagctgg ccccaaatac attggaacct caaatgttcc gtttgcatca gtcgttcctg 1545181 aagcagtttg tgttgtgttt ccgaccttcg tgtccgcttc aaatcttacg ggcgcgtttg 1545241 gcactggctg tccgttttgg tcgagtaatt tgccgcttac tgtaatattg tacttgactc 1545301 gccaatattg accttgtccg taattgattt taccgtatac ccctccatct gtgctgatat 1545361 ttgtgattga ggccttataa ggtgcctcag cagcgtctgc ttgctgtgcc gggaaaccta 1545421 ttgtaaacag ggctgccaga cataacataa acaataaacc gatttttttc ataaaaatcc 1545481 tccttaaaat agggttcata tacaatatcg gaataaattg gatgatattt agcgtatttt 1545541 ggaaaagtta atcgccgctt tgacaagata aaaacttgac agtgtcatta aaaccgtgta 1545601 aactaagtta tcgtaaaggg atttgactta acaaagggga gagctcaaat gtcactcgaa 1545661 aagacaacga gaatgaatta tctgtttgat ttttatcagt cgttgttgac gtcaaaacag 1545721 aagagctata tgtcgcttta ttatttggac gatttctccc taggcgaaat agccgaagaa 1545781 tatgaggttt caagacaagc tgtttatgat aacatcaaac gaacagaagc aatgcttgaa 1545841 caatatgaag aaaagctgct ccttttgaaa aagtttcagg agcgtaaaga gatgtttaat 1545901 aagctgaagg agcttgcttc cggttcaaaa gaagaggaag aaattacagc tctgattgaa 1545961 gcgcttgaga aattagatta ggaggcggca aactatggca tttgaaggat tagccgaccg 1546021 actgcagcag acgatttcta aaatccgcgg aaaagggaaa gtcagcgaac aagatgtaaa 1546081 agagatgatg cgtgaggtcc gtcttgcgct gcttgaggct gacgttaact ttaaagtagt 1546141 caaggatttt gtcaaaaaag taagtgaacg cgctgtaggc caagacgtca tgaaaagtct 1546201 gacgcccggc cagcaggtca ttaaagttgt tcaagaggaa ctgactgagc tgatgggcgg 1546261 cgaagagagc aaaatcgccg tcgcaaaaag gccgccgact gttattatga tggtcggtct 1546321 ccaaggtgcc ggtaaaacga caacaagcgg taagcttgcg aatctgctgc gcaaaaagca 1546381 taatcgcaaa ccgatgctgg ttgctgccga tatttaccgc ccagccgcaa ttaagcagct 1546441 ggaaacactc ggcaaacagc ttgatatgcc tgttttctct cttggcgatc aggtcagtcc 1546501 tgtagaaata gctaaacagg ctattgagaa agccaaggaa gaacattatg actacgtcat 1546561 tttggatacg gcagggcgct tgcatatcga ccatgaactg atggatgaac tgaccaacgt 1546621 caaagaaatc gcgaatccgg aagaaatttt cctggttgtc gattcaatga ccggtcagga 1546681 cgctgtgaat gttgccaaaa gctttaatga acagctcggt ttaaccggtg ttgtgttgac 1546741 taagctggat ggagacacac gcggcggggc tgcgctttct attcgcgctg tcacaaacac 1546801 gccaattaag tttgcaggtt tgggcgaaaa gcttgatgcg ttagagccgt tccatcctga 1546861 acgcatggca tcaaggattc tcggcatggg cgacgtgctg acattgattg aaaaagcaca 1546921 ggccagcgtt gatgaagaca aagccaaaga gctggaacaa aaaatgagaa cgatgagctt 1546981 cacattggac gattttctgg agcagctcgg gcaagtcaga aacatggggc cgcttgatga 1547041 gcttctgcaa atgatgccgg gtgcaggtaa aatgaagggc ctgaaaaaca tccaagttga 1547101 tgaaaaacag ctgaatcatg tggaagcaat catcaaatca atgactgttc ttgaaaaaga 1547161 acagccggat attatcaatg ccagccggcg gaagcggatt gcaaaaggaa gcgggacatc 1547221 cgtacaggaa gtcaaccgtc tgcttaagca gtttgatgaa atgaaaaaaa tgatgaagca 1547281 gatgacaaac atgtcaaaag gcaagaaaaa agggtttaag ctacctttta tgtaatcggt 1547341 tatacatgat aaaaccgttg ttaagaaaaa acactttaca aacactttta tcattgttaa 1547401 tatactatct tgttgaaata ttttcggagg tgctagtaaa atggcagtaa aaattcgttt 1547461 aaaacgtatg ggagcaaaaa aatctccttt ctatcgtatt gttgtagcag attctcgttc 1547521 accacgtgac ggccgtttca tcgaaacagt cggaacttac aacccggttg caaaaccagc 1547581 ggaagtaaaa attgacgaag agcttgctct taaatggctt caaactggag cgaaaccatc 1547641 tgatacagtt cgcaacttgt tctctagcca aggaatcatg gaaaaattcc acaacgctaa 1547701 acaaggcaag taatgactga tcaacacttg gaagatttga ttgtccacat tgtgacgccg 1547761 cttgttgatc atccagatga cattcgcgtc ataagagaag aaaccgatca aaagattgcg 1547821 ctgcgcttat ctgtccataa gtcagatacc ggtaaagtta tcggaaagca aggccggact 1547881 gcaaaagcga ttcgaacagc tgtatttgca gctggcgtac agtcttctaa gaaagttcaa 1547941 tttgaaatat ttgactaaaa gggagagggc cggcacctcc ccttttttta cacgcaaaaa 1548001 aagggtaaac tgatagaagc ttaggcaaaa tagaaaagcc tggacgagta aaagttttaa 1548061 aagcggggag cttggtgcga tgcaaattat tcaccgtgta gccgttatgc aagtcttaac 1548121 cgagcgcagt aaagaaaagc ttttagcttc ttttgctgag aagaaacaaa tgcttgaacg 1548181 agaatgcagc cagctctatt ttcagcttag aaaacatgag aaagaacagc aaaaccctaa 1548241 tatgattgaa caatttaaaa aggcaataga aaagcgaaaa gatgatataa aaatcattga 1548301 ttttcaaatt gctcaagtac atacattgcc gcttggcagt gagttgaaag aaaaggaagt 1548361 cgatgcgctg ctgacgattg aagccgggga tgactggcat gagaaaacag cagcgaacac 1548421 catcgtcata aaagacggaa aagtaattga aattcgccag aggtgatcat atgacaaagc 1548481 gatggtttaa tgtaggcaaa atcgtaaata cccacggaat caaaggcgaa gtgcgggtga 1548541 tttcaaaaac agattttgcc gaagaacgat acaagccggg aaacacgctg tatttgttta 1548601 tggacggccg taacgaacca gtggaggtaa cggtaaacac acatagactg cataagcaat 1548661 ttcatctcct gcagtttaaa gaaagacaaa acctaaatga agtagaagag ctgaaaaacg 1548721 caatcattaa agttcctgaa gaagaattag gagagctgaa tgagggtgaa ttttatttcc 1548781 acgaaattat tgggtgtgaa gtatttactg aagaaggcga actcatcgga aaggtcaaag 1548841 aaattttgac gcctggagcc aatgacgttt gggtcatcgg acgaaaagga aaaaaagacg 1548901 cactcattcc ttacattgaa tcagtggtta aacatatcga tgtcagggaa aagaaaattg 1548961 agattgaact catggaaggg ttaatagacg aatgaaaatc gattttttga cgctgtttcc 1549021 cgaaatgttt gaaggcgtgc tcggctcatc gattcttcaa aaagcccagg aaaaagatgc 1549081 ggtgcagttt caagtcgtaa atttccgaga gtactctgat aacaagcaca atactgttga 1549141 tgattatcct tatggcggcg gggcaggcat ggttctcaag ccccagcctg tttttgacgc 1549201 ggtcgaggac ctgacatcaa aggcagccgc tgctccgcgt attatcctcg tatgcccgca 1549261 aggtgagcgt tttacccaaa aaaaagccga acaattagct aaggaagagc atttgctgtt 1549321 catttgcggc cactatgaag gctatgatga acgcattcgc gagcacttgg taacggatga 1549381 aatatcaatt ggcgactttg ttctgacggg cggtgagctc cctgcaatga tgatcgcaga 1549441 cagtgtggtc agactgcttc cgggtgtact gggtaaagag gcttcccata ttgaggattc 1549501 cttcagcacc ggacttttag agcacccgca ttatacaaga ccggcagatt acaaaggttt 1549561 aaaagtgcct gaaacactct tgtcaggaaa ccatgcaaaa attgaagaat ggcggaataa 1549621 agaatcgatc agaaggacct acctaagacg tccggatctg ttgaaagacc acccgcttac 1549681 agagcagcaa agaaagtgga tttctgaatg ggaaaaagaa tagattttat tgcataggct 1549741 atgaaattgt gataagatac tacttgtggc ttaagcgggc ttatccgctg caagcttgaa 1549801 aacgatgttc cgctgtgccg gtttttgtgg ccaagagcat ctgttggaag gagttgaaaa 1549861 cgatgcaaaa actaattgaa gatatcacaa aagaacagct tcgtactgat cttcctgcgt 1549921 tccgtcctgg tgacacttta cgtgtacacg ttaaagttgt tgagggtaac cgtgagcgta 1549981 tccagatctt tgaaggtgtt gtgattaagc gtcgtggtgg tggaatcagc gaaacgttca 1550041 cagttcgtaa gatttcttac ggtgttggcg ttgaacgtac tttcccagta cacacaccaa 1550101 aaatcgcgaa aatcgaagtt gtacgttacg gtaaagtacg ccgtgctaaa ctttactacc 1550161 tgcgtgaact tcgcggaaaa gcggctcgta ttaaagagat cagacgataa tgataacgaa 1550221 cgaaaagagc ttgttacctg taacaagctc tttttttata cagaatttga aaatgccgga 1550281 caggcatcgt aaaatacata aaggacaaca atgaatcatg catactgaag ataaaggcgg 1550341 tgttcgtgtc acatgacaat tcaatggttc ccgggccata tggcaaaagc aagaagggaa 1550401 gtaaccgaaa aattaaaatt aatcgatatc gtatatgaat tggtagatgc cagaattcca 1550461 atgtcatcaa gaaacccaat gattgaagat attctaaaaa acaagccgcg aattatgctg 1550521 ttaaacaagg ctgacaaagc agatgcggca gttacacagc agtggaaaga gcactttgag 1550581 aaccagggga tccgctctct gtctattaat tctgtaaatg gacaagggtt aaatcaaatt 1550641 gtgcctgcat caaaagagat cctccaagaa aaatttgacc ggatgcgtgc gaaaggtgtg 1550701 aagccgagag cgattcgcgc tttgattatc ggcattccaa acgtcggaaa atcaacgctc 1550761 atcaaccggc ttgcaaagaa aaacatagca aaaacgggag acagacctgg tattacgact 1550821 tctcaacagt gggtcaaagt tgggaaagaa ttagagctat tagatacacc gggaattttg 1550881 tggcctaaat ttgaggatga gcttgtcggt ttgagactgg cagtcaccgg ggctattaaa 1550941 gactcgatta tcaatttgca ggacgtggcc gtgtttggtc ttcgttttct cgaagaacat 1551001 tacccagaac ggcttaaaga gcgttatggc cttgatgaga tcccagagga cattgccgag 1551061 ctgtttgatg caataggtga aaagcggggc tgtctcatga gcggtgggct catcaactac 1551121 gataagacga ctgaagtcat cattcgcgat attcgcactg aaaagttcgg caggctgtca 1551181 tttgaacagc cgacgatgta aaggcgcgca gaaatgcggg tctttatttt ttcttggctg 1551241 aaccgataca tacagtaagg gagaagagaa agtgaataca ttaaccgtaa aggacattaa 1551301 agaccgtttg caggaagtga aggatgcaca agacccattt attgcccaat gcgaaaacga 1551361 cccgagaaaa agcgttcaaa cgcttgtaga gcaatggctt aaaaagcaag cgaaagaaaa 1551421 agcgctgaaa gaacaatggg tgaatatgac ttcctatgaa aggctggcaa gaaacaaagg 1551481 atttcgcttg attgcaggtg ttgacgaggt cggccggggg ccattggcag gaccagttgt 1551541 cgccagcgca gtcatccttc cagaggaatg tgaaatactt gggctgacag actccaaaaa 1551601 gctttcagag aaaaaacgcg aggaatatta cgagcttatt atgaaggaag cactggcggt 1551661 cgggatagga attgtagaag ctactgtgat tgatgagatc aatatatatg aagcttcaaa 1551721 aatggcaatg gtgaaagcga tacaggattt gtcggataca cctgattatt tgcttgttga 1551781 cgcaatgaca cttccgctcg acacggctca ggcgtcaatt ataaaaggcg atgccaaaag 1551841 cgtgtctatt gcggcaggtg cgtgtatcgc aaaagtgacg agggaccgaa tgatgagcgc 1551901 ttatgccgaa acgtatccca tgtacggctt tgaaaaaaat aaaggctatg ggacaaaaga 1551961 acatttggaa gctctcgctg catacggccc aactgaattg caccgcaaaa ctttcgctcc 1552021 tgttcaatct ttcagataaa tcaccatgga caaggaggca cctttttaaa atgaacatac 1552081 gaaatgatgt gcaaaaggcg ctgcagcacc ttttcgggcg tacagccgtc ccgcaggaaa 1552141 catcaaaagt aaacgaagcg ctaaacgggg agaagcgtct cctcttagga aaagtgcttc 1552201 gtttactagg agatcagcat gccctgatcc aagtcggcaa tcaaactgtt cagggaaaac 1552261 ttgaaactca gcttcgtcct caggcatact attggttttc ctacgaaaaa aaaacggcag 1552321 agcaaacagg ccgtcttcag gtcgttcaaa gctttgatca aaatcctaaa accattcagg 1552381 atgcagctgg caaactttta aatgctattt cagtgaagac gtcaaacgca gctctcatga 1552441 tgacaggagc gatgctgaaa agcaaaacac ccgtaacaga aaatgatatc aaaacagctg 1552501 tccgctggat ggacacgctg ccttcgcaag acacaaaaaa agcagttgaa acggttctct 1552561 tcgctttaaa gcgtgatctt cccattcact ccgagatttt gaatggtgtt cacgctgtga 1552621 aatcgcctgt tccgttgcat cagcacgtat cccagctgct acaggcaatc gaccaaaacc 1552681 ctcagcagag ccaaatgatg tcaaagctaa aggaagcagt cacggtgctt ttaaatagtg 1552741 aaatcgatgt ccatgcagaa cggctgattg ataagcttat ttctttaacc gacaatacga 1552801 aagcaccttc tccgacgaat acagctggaa gcagggagct tagcacacca gctggctccc 1552861 ccggaaaagc cagcctgccg attgcaaatc acacagcaga acagggaagc atacaagaag 1552921 agcctgttaa aacagcagca gacattccaa ttaaagaagc ccgccagctg ctggtgaagc 1552981 tgacggaatc tgctgaaaaa aacagtctcc aaattgtgaa agaagcagca aattggatta 1553041 aagcggctgc ttcatcgggt gatagtaagt cacttgcagc ttcagctgtt ttacaggcgg 1553101 cacaagtcac agatcaggaa gccgaagtct ttttaaaggc tgttcagcag acagcacccc 1553161 atttggcgga taaggcagat gttctttctt tcttatccaa agtgaaaacg gcaatcggcg 1553221 caagggacga ggttgcgttc attaaagcgt ttgaacaagg aagcgcagtc acatctggcg 1553281 aaatgcaatc catcaagctg gctctttctg ccttaagagc atcgcatgag gtagccgaac 1553341 cagtcaaaca agaagccgat cagctttttc ataaattaaa tggccagctt ttcatgcagc 1553401 aggaccatcc atcatacagc caaattgtaa tgtcatttcc gatgttttcg aagtcagggg 1553461 ttcaggacat gactgttctg tttaaaggaa agaaagaagc ggatggaaag cttgatcctt 1553521 cccattgccg ccttttgttt ttgctgcagc ttgatacact aaaagaaacc gtcgttgatt 1553581 gcttggtaca gcaaaaagtc atgaccatta caatagagac tgatttcgag ctgcaggctg 1553641 cgatcgatcc gatggtgccc gcgcttaaac aggggctaaa ggaaatgggg tacagccttt 1553701 caggggtaaa cgctaaaaaa agggttcaca ccgaagaaaa ggcttcaatc gatcaatata 1553761 taacaagtat cagtgatcag gaagtggatg tgaaaatatg aaagagcaga caccgatcag 1553821 aaaagctgtt gctctccatt atgacgaaca aaaagacaag gcgccgagag tgattgccac 1553881 agggaagggc catgtagctg acaacattat aaaagaagcg aaaaaagcag gggtcccgat 1553941 tcaagaagat cggacccttg tcgaattaat gcgccatttg acggtagatg atcaaattcc 1554001 tgaagctctt tatgaaacgg tagccgagat tttttcattc atttacaaat tggacgaaag 1554061 cgtaaaaaac aaaaaatagc taaaatattc cccatccttc tttgaaattt atgtttttaa 1554121 taaagtaaaa gtttgaatgt ttagaaggat taaaagattt tgcatcgaac tgtagacaat 1554181 tcttccagta ttattataga atgaaagcgc agtctatttt agttttgtta cataagttag 1554241 gaggatggga aatgaatatc catgagtacc agggaaaaga agtcctcaga aaatatgggg 1554301 tatctgttcc tgaaggtaaa gtggctttta cagcagaaga agcagttgag agtgcaaaga 1554361 gcttatccag ctcggtttat gtcgtaaagg ctcaaattca tgctggcggt cgaggcaaag 1554421 ctggtggggt aaaaatagca aaatcattag acgaagtaaa agcgtatgcc gaagaactat 1554481 tagggaagac cctagttaca catcagacgg gtccggacgg ccaagtaata aaacgcttac 1554541 ttattgaaga aggctgcgat attaaaaaag aatattacat cggtctagtg cttgaccgcg 1554601 ccacttcaag aatcgtttta atggcttctg aagaaggcgg aacggaaatt gaagaggttg 1554661 cggagaaaac accagaaaaa atcaaaaaag ctgtcattga tccagctgtt ggccttcaag 1554721 gctatcaagc cagagaaatt gcattcgcta ttaatattcc aaaagagctc gtgggaaaag 1554781 ctgctaaatt tatgcttgga ctatataaag cgtttgttga gaaagactgc tcaatcgccg 1554841 aaatcaatcc gcttgttgtg actggcgacg gaaatgtgat ggcgcttgat gcaaaattga 1554901 attttgacag caatgcgttg taccgacaaa aggacattat ggaatacaga gatttggatg 1554961 aagaagatcc gaaagaaatt gaagcgtcca aatatgatct aagctacatt tcccttgatg 1555021 gaaatatcgg ctgtatggta aacggcgcgg gacttgcaat gtctacgatg gatattatca 1555081 agcattatgg aggagaaccg gccaacttcc ttgatgtggg cggcggtgca accgcggaaa 1555141 aagtcacgga agcatttaaa atcattcttt ctgatcaaaa cgttaaaggg atttttgtca 1555201 acattttcgg cggcattatg aaatgtgatg tcatcgcaga aggggttgtt gaagcgacta 1555261 gacaagttgg tttgacattg ccgcttgtcg tccgtcttga aggcacaaac gtggatctag 1555321 ggaagaaaat ccttagtgaa tcaggattaa acattacatc tgcggaatca atggctgacg 1555381 gcgcgcagaa aatcgtatcc ttagtttaag aaagaatgaa aggcagggga ccaaataatg 1555441 agtgttttca ttaataaaga tacaagagtt attgtgcaag ggattacagg ttctaccgct 1555501 ttatttcata cgaagcagat gcttgaatac ggcacaaata tcgttggcgg tgtaacacct 1555561 ggaaaaggcg gaacagaagc ggaaggtgtt cctgtattta atacagtggc tgaagcagtt 1555621 caaacaaccg gcgctaacgc gtctgttata tatgtgcccg caccgtttgc agctgatgcg 1555681 attatggaag cggtagatgc ggagcttgat ctcgtgattt gtatcacaga acatatcccg 1555741 gttttggata tggtgaaggt caaacgcttc atggaaggca agaaaacgag actgataggg 1555801 ccgaactgtc ctggtgtcat tacgcctgaa gaatgtaaaa tcggcattat gcccggatac 1555861 atccataaaa agggtcatgt aggcgttgta tcacgttcag gaacattaac atacgaagcg 1555921 gtgcaccagc tctcagaagc gggtgtaggg caatctacag ctgttggaat cggcggcgac 1555981 cctgtaaatg gaacaaactt tattgacgtt ttaaaagcgt ttaacgaaga tcctgacaca 1556041 cacgcagtca tcatgattgg cgaaatcggc ggtacggccg aagaggaagc ggcagagtgg 1556101 gtaaaagcca acatgacaaa accggtagtc ggttttattg gcggtaaaac agcacctcct 1556161 gggaagcgca tggggcatgc aggcgccatt atttccggcg ggaaagggac agctgatgaa 1556221 aaaatcaaaa cccttaatgc atgcggaatc gaagttgcag agacaccttc tgtcatgggt 1556281 gaaaccttaa tcaaggtgct gaaagagaag aacttgttcg aaacttgtaa aacgcattaa 1556341 taaaaaaggg acagccgtca aggctgttcc tgctttttct aacaaaagga ggtcaatcta 1556401 ttggatcagg ccgctgtctg cctaacgatt tgcagaatca atcaattatt atccccatcc 1556461 cttctattaa aatggtggaa agccgatccg tctatgtcgc tgacatcacc cgtgttacaa 1556521 acggttactc gtgatcaaat aaaagcagct gcattaaaaa acgaaataga acaattttat 1556581 ccaaagctcc cgcgtgtact tgctgcttat cgtgagcaag gcattaacac catccctatt 1556641 tcttcaaagc aatatccttt ctggcttaaa agcatttatg atccccctgc cgtactgttt 1556701 gcaaaaggtg atatgactct tctttcgaaa gggagaaaaa ttggaattgt aggcacaaga 1556761 aatccaacag cttatgggaa acaagttgtc aatcatctta caaaagagat ctgtcgtaaa 1556821 ggttgggtga ttgtcagcgg actggcgtct gggatagacg gaatgtccca tgctgcaagt 1556881 attaaggcga aggggcggac aattggcgtc attgcaggcg gatttcaaca catttatccc 1556941 cgagaaaacc ttcagttagc agatcacatg gctaaacacc atatcctgct gtcagagcac 1557001 ccacctgaaa ctaaacccca aaaatggcat ttccctatga gaaaccgtat tatcagcgga 1557061 ctaagtgaag gcgttattgt cgttcagggc aaagaaaaaa gcggttcgct gattactgcc 1557121 tatcaagcat tggaacaagg gagagaggta tttgccgtac ccggttcatt gtttgaccct 1557181 tacgccggag gtcctataaa actgatccag cagggggcta aagccatatg gtcagcagag 1557241 gatattttcg aggaacttcc tgagagaaac gttcaatata cggaaccctt ttgaattatc 1557301 gtttgacaaa cggtattgta atatttaata atagtgagga tttaaagttg catattgttt 1557361 tctatttaat taatgacgtt catgataaag aatgaaatgt tgaaagccaa ataaagacag 1557421 ctgcaaaaat aaaattgaaa tatcttgaaa agagagagaa cacctcttga gggggatgaa 1557481 aatgtctgat tatctagtca tcgtggaatc gcccgctaag gcgaaaacga ttgaacgtta 1557541 cttaggtaaa aaatataaag taaaagcatc aatgggacat gtccgggatc ttccaaaaag 1557601 tcaaatggga gttgacatag aacagaattt tgaaccgaaa tatattacca ttcgaggtaa 1557661 aggcccggta ttaaaagagc tgaaaacggc tgcgaaaaaa gccaaaaaag tgtatctcgc 1557721 agctgacccc gacagagaag gggaagcgat tgcatggcat ttggcacaca gtcttgattt 1557781 agatctcaac tcagactgcc gtgtggtgtt taacgaaatt acaaaagacg ctattaagga 1557841 atcgtttaag catccccgca tgatcaatat ggatttagtg gatgcacagc aagcgagacg 1557901 tattttagac aggcttgtcg gatataaaat cagtccaatc ttatggaaaa aagtcaaaaa 1557961 agggcttagc gcaggacgcg tgcaatccgt tgccctccgt ttgattattg accgtgaaaa 1558021 agagattaac gactttaagc ctgaggaata ttggacaatt gacggtacgt tcttaaaagg 1558081 tcaagaaacc tttgaagcga gctttttcgg gaaaaacggc aaaaaacttc ctttaaatag 1558141 tgaagctgat gtaaaagaga ttctttctca gctcaaaggg aatcaatata cagttgaaaa 1558201 agtaaccaaa aaggaacgca aacgtaatcc tgctttgcct tttaccactt ctaccctgca 1558261 gcaggaagcg gctcgcaagc tcaatttcag agcgaagaaa acgatgatga ttgcacagca 1558321 attatatgaa ggaattgatt taggaagaga aggaacggtt ggtctgatca cgtatatgag 1558381 aacggattca acccgtattt caaatacggc tgttgatgaa gcagctgcat ttattgatca 1558441 gacatatgga aaagagttcc taggcggaaa acggaagcct gcgaaaaaga atgaaaatgc 1558501 ccaggatgcc cacgaagcaa ttcggccgac atcagttctt agaaaaccaa gtgaattaaa 1558561 agcagtcctc ggcagagacc aaatgagact gtataaatta atttgggagc gttttgttgc 1558621 cagccaaatg gcaccggctg ttctcgatac aatgagtgtc gacctgacaa acaacggttt 1558681 gacatttcgt gcaaatggaa gtaaagtcaa gttttccggg tttatgaagg tgtatgttga 1558741 aggaaaagac gatcaaatgg aagaaaaaga ccggatgctg cctgacttac aagaaggcga 1558801 cacggtatta tcaaaagata tagaacctga gcagcatttt acccagccgc ctccgcgata 1558861 tactgaggcc cggcttgtta aaacccttga agaacgcggt atcggccgtc catccacata 1558921 tgctccgaca cttgatacta ttcagcggcg cggctacgtg gcattggata ataaacgttt 1558981 cgttccgact gaattaggtc agatcgttct tgacttgatc atggagtttt tccctgagat 1559041 cattaacgtt gagtttacag ctaaaatgga gagagatctt gatcatgttg aagaaggaaa 1559101 taccgaatgg gtcaagatta tcgataattt ctacaccgat tttgaaaaac gcgtcaaaaa 1559161 agccgaatcg gaaatgaagg aagttgagat tgaaccagag tatgctggag aggattgtga 1559221 attgtgcagt tctccaatgg tatataaaat gggacggtac ggtaaattct tagcttgctc 1559281 caacttccct gactgccgga acacgaaacc gattgtgaaa caaatcggtg tgaagtgccc 1559341 gagctgcgga gaaggaaaca ttgttgagcg aaaatcgaaa aagaaacggg tgttttacgg 1559401 ctgtgaccgt tatccggact gtgaattcgt atcatgggac aaaccaattg aacgaaaatg 1559461 cccgaaatgc ggaaaaatgc tcgtcgagaa aaaactcaaa aaaggtatac aagtccaatg 1559521 cgtggaatgc gattataagg aagaaccaca gaagtagcgg tgagcagggt cttgctcacc 1559581 ttctttgtgt gttaaaagaa ggccttgaat aataaactag gagatgtgaa agatgaacca 1559641 acaaacagtg aatgtaatcg gagccggact cgcaggaagt gaagcagcat ggcagcttgc 1559701 caaacgtggg attcaagtca aattgtatga aatgcggcca gttaaacaaa cgcctgcgca 1559761 tcatacagat aaatttgctg agcttgtctg cagcaactct cttcgctcta atacacttgc 1559821 taacgctgtc ggtgtattaa aggaagaaat gcgtgcgctt gattcagcca ttatcgctgc 1559881 ggctgacgaa tgttcggtgc ctgccggggg cgctcttgca gtagaccgtc atgaatttgc 1559941 cgcaagtgtg acaaatcggg tgaaaaatca tccaaacgta accgttatta atgaagaagt 1560001 gactgaaatt cctgaaggcc ctactatcat cgcaacgggt ccgttaacat ctgaatcgct 1560061 gtctgcccag ctgaaggagc tgactggaga ggactattta tatttttatg acgcagcggc 1560121 gccaattgta gaaaaagaca gccttgatat ggataaagtg tacctgaaat cccgttatga 1560181 taaaggtgaa gcagcatatt tgaactgccc gatgacagaa gaagagtttg accgttttca 1560241 tgaagcatta acatcagcag aaacagtgcc gttaaaagaa tttgaaaaag agattttctt 1560301 tgaaggctgc atgccgattg aagtcatggc aaaacggggt aagaaaacaa tgcttttcgg 1560361 tccgatgaaa ccagttggtc tagagcatcc tgttacagga aaacgccctt atgccgtcgt 1560421 tcagctcaga caggatgatg ctgcgggaac actttataat attgtaggat tccagacaca 1560481 tttaaaatgg ggagaccaaa aggaagttct caagttgatt ccaggacttg aaaatgtaga 1560541 aatcgtcaga tatggcgtga tgcatagaaa cacatttatt aactctccaa gcctgttaaa 1560601 gccgacttat caatttaaaa accgcagtga tctgttcttt gcaggccaaa tgacgggagt 1560661 agaaggatat gtggaatcag ctgcctcagg acttgtagca ggcattaatg cggcgaagct 1560721 tgtattggga gaagagcttg tgatcttccc tcaggaaaca gcaattggca gtatggcaca 1560781 ttatattaca acaacaaacc agaagaactt ccagccgatg aatgcaaact ttgggctttt 1560841 gaaagaattg ccagttaaaa ttaaaaataa aaaagaacga aatgaacaat acgcgaaccg 1560901 tgcgattgaa acaattcaaa caatttcgaa aacaatatag gtattgattg caacctgagc 1560961 gcgatttgtg ataccattta aaagcccttc ctggggaggt attaggcatg gagaatgtta 1561021 agaatttcgt aaagttattc gttgaatatt tacaaattga aaaaaattat tcacaatata 1561081 ctattgtgaa ttatgtggat tcaattgaag aattcgagac tttcctgcgc gttcaaggta 1561141 taaatggatt tgaagaagct gcatatcaag atactaggat ttttttgaca gaagcctatg 1561201 aaaaaggttt atcgagaaga acaataagca aaaagatatc tgcattaaga agcttttata 1561261 agtttctgat gcgggaaaag cttattgaag aaaatccgtt tcagcttgtt catctgccaa 1561321 aacaggagaa acggataccg aagtttctat atcaaaaaga gcttgaggag ctgtttgaag 1561381 tttcagatat aagccagccg gccggaatga gggatcaagc gctgttagag ctgctctatg 1561441 ccactggaat gagggtcagt gaatgctgtt ccataactat taacgacgtt gatttattta 1561501 tggacactgt gcttgttcac ggtaaaggca agaagcagcg ctatatcccc tttgggtctt 1561561 atgcccgcga agcgttgaag gtatacatga atagcggaag acagtgcttg ctgatgaagg 1561621 caaaagaacc tcatgatcta ttattcgtaa atcaaagagg cggaccgctt acagcccgtg 1561681 gcatcagaca tattttaagc gggcttgttc aaaaagcgtc aagcacttta catatccatc 1561741 cgcatatgct tcgacatacg ttcgccacgc atctgttaaa tgaaggagcg gatttgagaa 1561801 gcgttcaaga actgctcggg cattccaatc tgtcttctac acagatatac acgcacgttt 1561861 cgaaggaaat gttgagaaac acatatatgt ctcaccatcc aagagcattt aagaaaaatt 1561921 aaaggaggcc ctttatgtca tcttttcatg cgaccacaat atttgccgta cagcataaag 1561981 gacgaagcgc tatgtccgga gacggccaag taacatttgg tcaggctgtt gtcatgaaac 1562041 acacggcacg gaaagtgaga aaactgttta acggcaaagt tcttgctggt tttgcgggat 1562101 ctgttgcaga cgctttcact ttattcgaaa agtttgaagc taagcttgaa gaatataacg 1562161 gcaacttaaa acgggcggct gttgagcttg caaaggaatg gcgcagtgat aaagtgctaa 1562221 gaaagctcga agccatgctg attgttatga atcaggatac tttgcttctc gtatcgggaa 1562281 caggcgaggt gatcgaacca gatgacggca ttctcgcgat tggatcagga ggcaattacg 1562341 ctttggcagc gggaagagca ctgaaaaagc atgccgggga aagcatgtct gcaagtgaga 1562401 ttgccagagc cgcgttagaa acagcaggcg aaatttgtgt ttacacgaac gatcaaatca 1562461 tactggaaga gcttgaatag aaaggacttg aggcgcatgg aaaaaaaacc gttaactcct 1562521 agacagattg tagatcggtt agaccaatat attgtcggtc agcaaaatgc gaaaaaagct 1562581 gtcgccgtgg cattaagaaa ccgctataga agaagtcttc tggatgaaaa gctgaaggac 1562641 gaggtcgttc cgaaaaacat tttaatgatg ggtcctaccg gcgtcgggaa aactgaaatt 1562701 gccagacgaa tcgctaagct ttcaggtgcg ccatttatca aaattgaagc tactaaattt 1562761 accgaagtcg gctatgtagg cagagatgtt gaatcaatgg tcagagatct tgtggagact 1562821 tctgttcggc ttataaaaga agagaaaatg aatgaagtaa aggaacaggc agaagaaaat 1562881 gcaaacaaac gcattgttcg tctgttagtt cctgggaaga aaaaacaatc tggtgttaaa 1562941 aatccgtttg aaatgttttt tggaggcagc cagccgaatg gtgaagatga ggcggagagc 1563001 caggaagaag caaacatcga agaaaaaaga aaacgaatgg cgcatcagct ggctttagga 1563061 gagctcgaag actactatgt aacagtagaa gtcgaagaac agcagccttc tatgtttgac 1563121 atgctgcagg gctcgggtat ggagcagatg ggtatgaaca tgcaggatgc gctgagcgga 1563181 ttaatgccaa agaaaaagaa gcggcgcaaa atgacagtca gagaagccag aaaagtcctg 1563241 acgaatgaag aagcaagcaa actcatcgat atggatgaag tcggccagga agctgttcag 1563301 agagcagaag agagcgggat tatctttatc gatgagattg ataaaatcgc aaagaacggc 1563361 ggtgcatctt cttctgccga tgtttcaaga gaaggtgttc agcgggatat ccttccgatt 1563421 gttgaaggtt ctaccgttgt cacaaaatat ggttctgtaa aaacagacca tgtattattt 1563481 attgcagcag gagcgtttca tatggccaaa ccgtctgatt tgattcctga gctgcagggg 1563541 cgtttcccga ttcgtgtaga actgaacaaa ctcacggtag acgacttcgt gagaattttg 1563601 gttgagccgg ataatgcgct gctgaaacaa tatcaggcat tattgcagac agaaggtata 1563661 tctcttgaat tttctgacga agctattcat aagattgctg aagttgctta tcatgtgaac 1563721 caggacacag ataatatcgg tgcgagacgc cttcatacaa tacttgaacg cctattagaa 1563781 gatttgtcgt ttgaagctcc agatgtaacg atggagaaaa taacgattac accacagtat 1563841 gtcgaagaaa agctcggaac gatagccaaa aacaaagatt taagtcaatt tatattgtga 1563901 aaaatttaat atgaggaatg tttaggagga ttatttatca tggctttatt acaaaaaaca 1563961 agaattatta actccatgct gcaagctgcg gcagggaaac cggtaaactt caaggaaatg 1564021 gcggagacgc tgcgggatgt aattgattcc aatattttcg ttgtaagccg cagagggaaa 1564081 ctccttgggt attcaattaa ccagcaaatt gaaaatgatc gtatgaaaaa aatgcttgag 1564141 gatcgtcaat tccctgaaga atatacgaaa aatctgttta atgtccctga aacatcttct 1564201 aacttggata ttaatagtga atatactgct ttccctgttg agaacagaga cctgtttcaa 1564261 gctggtttaa caacaattgt gccgatcatc ggaggcgggg aaagattagg aacacttatt 1564321 ctttcgcgtt tacaagatca attcaatgac gatgacttaa ttctagctga atacggcgca 1564381 acagttgtcg gaatggaaat cctaagagaa aaagcagaag aaattgaaga ggaagcaaga 1564441 agcaaagctg tcgtacaaat ggctatcagc tcgctttctt acagtgagct tgaagcaatt 1564501 gagcacattt ttgaggagct tgacggaaat gaaggtcttc ttgttgcaag taaaattgct 1564561 gaccgtgtcg gcattacccg ttctgttatt gtgaacgcac tcagaaagct ggagagcgcc 1564621 ggtgttatcg agtctagatc attaggaatg aaaggtactt atatcaaggt actaaacaac 1564681 aaattcctaa ttgaattaga aaatctaaaa tctcattaat cacaaaaaga accctttttg 1564741 agggttcttt ttttatttca aataaaggaa atcaataagc tttatttcct gggttgaaag 1564801 tctttctatg taataatttt aataaatttt gcatttttct tcaaaaagtt tcaaaaatgc 1564861 cgaaaagaaa ggagaaaaaa cagaaattct gctattttca ggcttatatc aaggcgagaa 1564921 atgtagttct aacaatctag gactttatac ctagttgcaa aatagataat tgtgaggaca 1564981 tttttttaca cgaacttcat agactttatg cctgttattt cttacaataa gcatatagtt 1565041 ttacaattct cgacaaggat attgagggtg aaaaaaactg aaatggaggt aagtggattt 1565101 gagcttattt tctggaacga tacaaaatct tgaaaatgcc ttgagcagag cggatattaa 1565161 gcaaaaagtc ataactaata atatcgccaa tatagataca ccgaactata aggcaaaaaa 1565221 agtctctttc caaaatttat tagatcaaga atcctcgcgt cttgaagcga taaaaacaga 1565281 ctatcgtcat gttgattttt ctgatactga ttcgaattat tcaattgttg cgagcggaga 1565341 tacatcgtat cagcaaaacg gaaacaatgt tgatgttgac aaagagatga cagaattggc 1565401 gcaaaatcaa atcaactatc aagctttggt tgaaagaatg aacggtaaat ttaattcgct 1565461 gaagaccgta ttaacaggag gaaaatgatg acagcttttc atagcttaaa tgtttcagca 1565521 tcggctttaa cagctcagcg agtcagaatg gacgttgtat catctaactt agcaaatatg 1565581 gatacgacaa gagctaagca ggtgaatgga gagtgggtgc cttacagaag aaaaatggtt 1565641 tcccttcagt caaaaggtga atcgttctct tccattctca attctcaaat gagcggaagc 1565701 gggaatgctg gaaacggtgt gaaggtttca aaaattacgg aggatgattc ggattttaat 1565761 cttgtctatg atccgacaga ccctgatgca aacgctgaag gatatgtaca aaagcctaat 1565821 gttgatccat taaaggaaat ggttgatctt gtcagcagca ctagatcata cgaggcgaat 1565881 gtcacggcga tgaatgccac aaagggaatg ctgatgaagg cgttagaaat cggaaagtag 1565941 gtgaatgaat gtgattaatg caatttctcc ttttcaggtt caaaatactc aaaacactca 1566001 aaatgcaaca aatcaagtaa acaatagcca aaaaacagat tcttcaaatc aaacaagctt 1566061 ttcggagctt ttaaaaaact ctattagttc gttaaatgag tcccaagtag cttctgacaa 1566121 catgactaat gccttggctg caggaaaaga tgtaaatctt gatgaggtca tgatcgctgc 1566181 tcaaaaagct agcatctctc taactgcagc aacagagttc cgcaataaag ctgtggaagc 1566241 ttatcaggag attatgagaa tgcaaatgta gggggtctga cgatttagag aaagagtgga 1566301 atgaccgggg gttaacatga atcgtactct aatgcaaatg aaaaacaaaa cgagtgagtt 1566361 ttggaaaaat agatctaaat tacaaaagat tttaatggtt agtgctttag cggcaattat 1566421 tattattgga attattatta gtgtttttgc ttcaaattct aaaatggcgc cgctgtacaa 1566481 agatttgtct gccgaagaag caggacaaat caaagaagaa ttggatgcaa aaaaagtgcc 1566541 aaacgaactt tcgaatggcg gtacagtgat tagtgttccg gaggatcagg ttgattcttt 1566601 gaaagtgcag atggctgcag aaggacttcc taaaacggga tcaattgatt attcgttttt 1566661 tggacagaat gccggctttg gtttgacaga caatgagttt gatatggtga aagtgaaagc 1566721 tacacagaca gaactgtcaa acttgatcaa tgaaatggac ggtattaaaa attcaaaagt 1566781 aatgattaat ctcccgaaag acgctgtgtt tgtcggtgaa gagcaatctg cagcatctgc 1566841 atcaatcgtt ttgcagattc aaccgggtta tacacttgat caaagccaaa tcaacggatt 1566901 atatcatctg gtatctaaaa gcgtgccaaa cctaaaagaa gataacatcg tcatcatgga 1566961 ccaaaattct acatactacg acaaatcaga cagcgatgca gggtcctacg cggatagtta 1567021 ttcttctcag caaggaatta agtctcaagt tgaaaaagac attcaaaaac atgtacagtc 1567081 actgctgggt acgatgatgg gccaagataa agtcgttgtc tccgttacag cagacattga 1567141 tttcacaaaa gaaaatcgga cagaagacat tgtcgaacct gtggataaag aaaacatgga 1567201 aggcattgca gtcagcgctg aaaaggtatc tgaaacatat cagggcgacg gtgcagccaa 1567261 cggcggaact gccggaaccg gcgaggaaga tgttacaaat tataaggctg acggtgaaaa 1567321 taccgaaagc gggaactacg aaaaaaacag caacaaaatc aattacgagg ttaaccgaat 1567381 tcataaagaa atcgctgaaa gtccttataa ggtcagagat ttagggattc aagtaatggt 1567441 agagccgcct gatgccaaaa acactgcgtc gctatcaact gaaagacagg atgatataca 1567501 aaaaatcctt tcaactgtag tcagaacatc tttggataaa gatgaaacgc aaaatcagaa 1567561 tttatctgat gctgatatca ataataagat tgttgtttcc gttcagccat tcgacggaaa 1567621 agtcaatttg gatacaaata cggaagaatc ctcaggtatc ccgctgtggg catatattgt 1567681 aggcggtgtt ttaatcgcag cgatcattgt tctgatcatt atgcttatca gaaagaaacg 1567741 ggcgcaagag gatgaatttg aggaatatga gtatgaggtt cctcaagaac caatcaattt 1567801 gcctgatatc aacgaagagg aaaatgaaac agcggaatca gtcagacgaa aacagcttga 1567861 aaagatggcg aaagacaagc cggaagattt tgcaaaactg ctgagaagct ggctggccga 1567921 ggattaggag gaattagaaa tggcgagacg tgatcaagat aagcttacag gaaaacaaaa 1567981 agcagccatt ctcatgattt ccttggggtt agatgtgtca gcttctgtct ataagcactt 1568041 aaccgatgaa gaaattgaaa ggcttactct ggaaatatca ggtgttcgaa gcgtcgatca 1568101 tcaaaaaaag gatgaaatca tagaagaatt tcataatata gccattgcgc aagattatat 1568161 ttctcaaggc ggtttaagct atgcaagaca agttctggaa aaggcgcttg gagaggataa 1568221 ggcggagaac attctaaaca ggctgacttc ttctttgcag gttaaaccat ttgattttgc 1568281 cagaaaagcg gagccagaac aaattttgaa ttttatccag caagagcatc cgcagacgat 1568341 ggcgttaatc ttgtcttatt tagatccagt gcaggccggg caaattttat ccgagctgaa 1568401 ccctgaagtg caggctgagg ttgcgagaag aatcgcggtc atggatagaa cgtctccaga 1568461 aataattaac gaggtagaac ggattctgga acaaaaatta tcttctgcat ttactcagga 1568521 ttatacacaa acaggcggaa ttgaagctgt tgtggaagtg ttaaacgggg tagacagagg 1568581 gacagagaag acgatcttgg attcattgga aattcaggat cccgatcttg ctgaagagat 1568641 taaaaagcgg atgtttgtct tcgaagatat tgtcacactt gataaccgtg caattcagag 1568701 agtcattcgc gatgttgaga acgacgattt gctcctttca ttaaaggttg caagcgagga 1568761 agtcaaagaa attgtgttca acaatatgtc acagcgtatg gttgaaacct tcaaagaaga 1568821 aatggagttt atgggccctg tacgtttgaa agatgtagaa gaagctcaat caagaattgt 1568881 aagcatcgtc agaaagcttg aagaagccgg tgaaattgta atagcaagag gcggagggga 1568941 tgatattatt gtctaatatc attaaacaag aatcatctat ttctccacaa aaggaaaaaa 1569001 gaaaactttc tatacaagag gtgcgtattg atcattctca ccttttgcag gctgaagaga 1569061 acccggaggc gcttatggcc cgagtgaaag aggaagctga ccggatttct gagcaggcaa 1569121 acagtcatat agaaaatatt cgccgtcaaa ttgaacagga gaaaaacgat tgggcggctg 1569181 aaaaacagaa gcttattgaa gaagcaaaag ccgagggctt tgaacaagga gtagcgctgg 1569241 gcaaagctga ggcaatgaaa cagtatgcag aactgatcgg ccaagcaaac agtataactg 1569301 aaatgtccag aaaagctgtt gaggacaagc ttgaagacgc taatgaagaa atcgttgagc 1569361 ttgccgttgc cctagcaaaa aaagtttggc agcaaaagtc tgatgataaa gaggctttcc 1569421 tcctgcttgt acaacaggtt ataaacgaag tgaaggaata tgacgatata tcaatttatg 1569481 ttgatccata ttactatgag acaatctttc agcaaaaaga tgaaatccag cagcttcttt 1569541 ataaagaatg tcggcttggc atatatgctg atgaaaaagc tcaaaaagga acctgttata 1569601 ttgaaactcc ttttggcagg gtagatgcga gtgttgacac acaattgatg caattgaaag 1569661 ataaacttct gacagcgctg gaagcaggtg cagctgaatg aagacacaga gtctgataga 1569721 ttgtatagaa atgacagact cgtataaacg gtacggaaaa gtcaagcggg taatcggctt 1569781 gatgattgaa tcaaaagggc cagcaagctc aattggtgac ctgtgcctga tttatgcaaa 1569841 aggacagtct gggaaagtca ttaaagctga ggtagtcggc ttccaggaag aaaatatttt 1569901 gcttatgcct tatttagagg ctgcgagcat tgcacctggc agcattgtag aagctactgg 1569961 ggaatcactt cgggttaaag ttgggaccgg actgatcgga caagtcatcg atgcttttgg 1570021 agaaccgctt gacggaaagc ttctgccgaa agggctttcg cctgtatcaa cggagcaatc 1570081 accgcctaac ccgatgaaac ggccgcctat ccgtgaaaag atgggtgttg gagtcagatc 1570141 aattgacagc ttgctgacag tcggtaaagg ccagcggatt ggaatttttg caggaagcgg 1570201 tgtcggaaaa agcaccttaa tggggatgat cgccaagcag acagaggctg acttaaacgt 1570261 cattgcactt gtcggagaac gcggacgaga ggttcgggag tttattgaaa aagatctggg 1570321 gaaagagggg ctgaaacgat cgattgtagt cgttgccacc tcagaccagc cagcattaat 1570381 gagattgaaa gcggcatata cagcgactgc aattgccgag tatttccgag ataaaggcca 1570441 aaatgtcatg tttatgatgg attctgttac aagggtggca atggcgcagc gagagattgg 1570501 actggctgca ggagagcctc cgacgacaaa aggctataca ccttcagtgt tcgctatttt 1570561 acctcgttta ctagaacgaa caggtgcaaa cgagcatgga accattacgg cattttatac 1570621 agtgttggta gatggggatg acatgaatga gccgattgcc gataccgtac gcggaatttt 1570681 agacgggcat attgtgttgg acagggcgct tgccaataaa ggccagtttc ctgcagttaa 1570741 cgtactaaaa agcatcagca gggtgatgtc aaacatttca acaaaacagc atctggatgc 1570801 ggcaaataaa ttccgtgaac ttttatcgac atatcaaaat tcggaagatc tcattaatat 1570861 cggagcttac aaaagaggat catccagaga aattgatgaa gcgatacaat tttatccgca 1570921 gcttattcaa tttttaaagc agggaacaga cgaaccggct ttattggaag aaagcattgc 1570981 tgcattaact agtttgacag gaaatgagga ataaacgtgg cttatcaatt tagattccaa 1571041 aagctgctgg aactaaaaga aaatgaaaaa gaccaatcct tatccgaata tcagcaatca 1571101 gtttctgaat ttgaaaacgt tgctgaaaaa ttatatgaga atatgagcaa aaaggaattg 1571161 ctggaacaaa ataaggaaaa gaaattaaaa agcggcatga gtgtacaaga aatgaggcac 1571221 taccaacaat ttgtctcaaa tcttgataat acgatctatc actatcaaaa gcttgtcatt 1571281 atgaaaagaa atcaaatgaa tcaaaaacaa gaaattttga cagagaaaaa cattgaagtg 1571341 aaaaagtttg aaaaaatgcg tgaaaaacag tttaaaatgt ttgctcttga agataaagct 1571401 gcagaaatga aagaaatgga cgatatttcg attaagcagt ttatgattca aggccattag 1571461 gagcgaatgt aatgtccggc aaaaagaaag aatcaggtaa gttccgttcg gttttgctta 1571521 tcattatcct cccgctgatg tttctattaa tcgcaggggg gattgttctt tgggctgctg 1571581 gtatcaatgt cttaaagccg atacaggatg ctgcggcaaa aacgccggtt cttaaagaat 1571641 tggtccctga aaccgaaaat aaaaaaggcg cagcatcaag taaggatagc agtaatacgg 1571701 cagctctgga aaagaccatt aaggatcaaa aaagtgaaat cagtatattg aataaagatt 1571761 tagaaacaag taaatcagaa atcgacaggc tcaatcaaaa gatccgttca cttgaaaaga 1571821 cggctgagga tcaaaaaaag tcatcagaag atcatactga aggatcagca gactcgaaag 1571881 cttcttctga aaatgacaaa gtgatcagtg tgtacaaaag catggacagc ggaaaggctg 1571941 ctaaaattat tgcccaatta aaggagcaag aagcactgaa aatattgaat ggcctaagca 1572001 aaaagcagct tgctgacata ttggcgaaaa tgactcctga gcaagcagca acctatacag 1572061 aaaaaattgc tgccagccaa gaataggggg aatgaaaggt gaagctgctt gaattagccg 1572121 gacctttgct gcaaaccaca acgggttctg ccgctaaaaa catgaaaagt agccagggag 1572181 tttttcaaaa ctggcttatg tctgaggctg gattgaagga actttcagaa caaggaaagg 1572241 gaactcctaa ttctgaagat cagcttttag cagatgcgct taaaaagatc ggtgaatggc 1572301 taaatgcaag tcctgaagat caagacaaac aaaatgcgga tcttttgcaa acattaagca 1572361 aactgacagg gaagcaattg gatgcgaatg ctctgcaaat gttgcaaaat cttttgcaag 1572421 cagttgaatc aaaaatgtca ggcgggacgg atcaattgct cacagaaacg gagaaaatct 1572481 tttcagaagc taaaacggct ctgagtgcca atgattctgc ttctgacatt aatggagcac 1572541 tgaagtctga taaagagcaa tcaaatcagg aaaatgaagt atccgagcct gcaaaagagc 1572601 ttatctatat ccagatgttc attagccagc tcgtagaagg gaataagctg actgatctcg 1572661 ggaatggcaa tgaagctcat gccatttacc aaaatggaga tcaattcctt tctgcattag 1572721 aaaagaaggg tgtatctcaa caactaattc aggatcttaa acagcaaata ttcactaaag 1572781 ctgagtcaag ttcaaaactt tactcgatga cagcgtcaga gctgaaaagt tttcaaagct 1572841 taatggatca aatgtctatg cttcctcaaa aagggaccaa agaatggagt ttagctgaaa 1572901 gccagctgaa agccttcttg ttatcgaaat catccgaatc atcacaagac tttgggaaga 1572961 gtgttctcac accgctctcg cagagttcat ccagcaaaaa tgcatcggat gtttctggaa 1573021 gtattcagcc tgtagatagt aaatcaggac tccaaatgct gttttcgggg tatcggggca 1573081 taggaggagt tcaaacactt gatctgcagc agatgtcatc tgatatacca aatgccgaaa 1573141 caaaaacggt ggctgatcaa gtgattaatg cgtggaagca gatgaaatat acgcctttcg 1573201 gcagatcgac gggaagtttc actattcggc tgaaccctga acatttagga tttgtcacaa 1573261 tcaagctgac aaatgaaaat ggaatgtttc agagtaaaat catagcatct agccaatcag 1573321 caaaagaatt gcttgaacag catcttcctc agctgaagca atcattgccg aatatggccg 1573381 tccaaattga ccgttttact cttccggtcc aaagcgggga tcagccgata tacggccagc 1573441 ttgctgatga acagaaacag cagcaagagg ggcagagaca gcaaagacag aaaaagcaat 1573501 caaatgattt tggcgatctg ctcgatgaag tgtcgatggt tgaaatggag gaagaagaat 1573561 gacttctata agttcagaat ataaactgcc tgaaaaaacg aacactgtgt cgacgaacaa 1573621 cagcagcttg gggaaagacg agtttttaaa aatattaatg actcaagttc aaaaccaaga 1573681 tccgcttaac ccgattgacg ataaagaatt tatcagccag atggcgactt tttcaagctt 1573741 ggagcaaatg atgaatctga atacgacaat gactcaattc gttgaaaacc aagatccgtt 1573801 tacaacgtat gttgattgga tgggaaaaga agtatcttgg actgatggta aaagtgcaac 1573861 agataaaaca ggcacagtaa gctctgttaa acattttaaa ggaaattatt atctcgttct 1573921 tgatgatggg accgagatca gtcctgcgaa tgtcatgtct gtgggacaat catctaaata 1573981 aaaacatctg ggggaatata ttatgttacg ttcactttat tctggaatca gcggtatgaa 1574041 aaactttcaa acaaagcttg acgtaatcgg taacaacatt gccaacgtaa atacagtagg 1574101 attcaaaaag agccgtgtga cctttaaaga tatggtaagc caaacgattg ccggcggttc 1574161 tgctgctggt gcaacaatcg gcggaacaaa ctctaagcaa atcggtttag gttcatcatc 1574221 tggcacaatt gatacaattc attcaacaag cgcgacacaa agcacaggaa gaacacttga 1574281 tttagcaatt gacggcgacg gttacttccg aattgataca ggtgacggga cagcttatac 1574341 aagagcaggg aacttctatt tagataatac tggaacactg gttacaggtg atggctacca 1574401 tgtactaaat atgaatggcg gaacaattaa aattcctact gatgctcaaa gctttagcat 1574461 tggttctgat ggaaaggtgt caattgttga tgctgagggg aaaacacaag acgggggaca 1574521 aatcgggatt gttacttttg ccaacagtga tggattggat aaaatcggaa gcaacctata 1574581 ccgtgaatct ttaaactctg gaacggccag tgcagcgaac cagcctggtg acggcggaac 1574641 tggtgctctt aaatcaggat ttctcgaaat gtctaacgtc gatttaactg acgaatttac 1574701 tgaaatgatc gtagcccagc gcggattcca atcaaactca aaaattatta caacatctga 1574761 tgaaatcctt caagaactgg ttaaccttaa acgttaagga gggaggggag gcgagtaatc 1574821 gcttctccgc tgttttatga ttaaagtaac ccgtttgaac gggcagccct ttacactgaa 1574881 tgcgctattt attgaacaga ttgaatgttt tccggatact acaattactc tgtcaaatgg 1574941 taagaagttt gtagtaaaag aagatgaaga agctgttctg gaaaagatcg cagctttcta 1575001 ccgaaaaata caaatatttg caatggatca aggaatagag gaaccggaat gaagaaaaag 1575061 ttaatgatca tattactaat tattcttatc gtaattggtg ctctcggggc ggcggcttat 1575121 tttgttttag gcggaaagtc cgaaaaaagt gaagcgaaaa aaagtattga tgaaatcgtt 1575181 gcgtcttctg ttgatgtaga agagatcaca acaaatttaa agtctgataa cattatccgt 1575241 cttgctatta aacttgaaac tgattctgat aaatcaaaag aagaacttga gaaacgtgat 1575301 ttccaagtga aagacgctgt tatatcactg ctggctgata cgaatgctga tcagattgag 1575361 ggagacaagg gaaaagaaac ctttaagaag gaactaaaag ataaaataaa tagctacctc 1575421 caagaaggaa aagtagaaaa agtgtatatt acctccttta atctgcaata aagcataatt 1575481 tgacagaata cggaggtgag gaaaatgtca ggagaagttc tctcccaaaa tgaaatagat 1575541 gcactgctct ctgcaatatc aactggtgaa atggacgctg aagagctgaa aaaagaagaa 1575601 aaagagaaga aagtcaaggt ttatgatttc aaacgtgcgc tgcggttttc taaggatcag 1575661 atccgcagtt taacgagaat tcatgacaat tttgcaagac ttcttaccac tcatttttct 1575721 gctcagctca gaacctatat tcacatatct gtcagttctg ttgatcaggt tccgtatgag 1575781 gaatttatca gatcgattcc aaacatgacg attctgaatc tatttgatgt tcatccgatg 1575841 gaaggaagaa ttatgatgga ggtcaacccc acgatagctt atacgatgat ggatcgagtc 1575901 atgggcggga ttggaatcag tcataacaag gttgacagtt tgacagaaat tgaaacaaaa 1575961 atcatttcta atttatttga aaatgcactg ggtaattata aagaagcttg gcagtcaatt 1576021 gctgatattg aaccggaaat gactgagttt gaagtgaatc cgcaatttgt tcagatggta 1576081 tctcctaatg aaacagtcgt ggtgatctcg ctcaatactc aaattggtga aatcagcggt 1576141 gtcattaatc tctgtatccc gcatattgta ctcgagccgc tcataccgaa gctttcagtc 1576201 cactattgga tgcaatcaga ccgaaatgag ccaaagcctg aggaaacaaa gtcgcttgaa 1576261 aaacgtatca tgacagcaca aatacctgtc gtggccgagc tcggcacatc tgaactgacg 1576321 atagaagagt ttttaagttt agaagtcgga gactgcataa ctttggacaa atcagtcacg 1576381 gatcctctta ctgtattggt cggagataag ccgaaatttt taggacaagc cggccgggtg 1576441 aatcgaaaac aggcagtgca aattttagat cacgacataa gaggtgaaca agatggagaa 1576501 taatagatta tctcaagatg agattgacgc gcttcttaac ggtactggca gcacgcttga 1576561 tgagccagag attccggaag tagatgactt atcggaaatg gagcgtgatg cgatcggtga 1576621 aatcggtaat atttcattcg gcagttctgc gacagcactg tcaacgcttt taaatcaaaa 1576681 ggtcgatatt acgactccaa gcgtaacggt cattccaaga agtaaaatca gcgatgcgtt 1576741 tcctgaaccg tatgtagcga ttgaagtgaa ttatacggag ggcttcagcg gaagcaacct 1576801 gttagtcgtg gaacaaagtg acgcggcgat cattgcggac ttaatgatcg ggggagacgg 1576861 aaaaggtgcg gacccttcac tgggtgaaat ccatttaagt gcggttcaag aagcaatgaa 1576921 ccaaatgatg ggatcggctg ccacatcaat gtctactgta ttcagtaaaa aaattgatat 1576981 ttcacctcct cgggttgaat tgctggatgt tactgaagaa aagggtacag accgtattcc 1577041 tgatgatgaa atgctggtga aagtttcttt caacttaaag gtgggagaat taatagactc 1577101 cagcattatg caactttacc cattgacatt tgcgaaagat ttaatttcaa gccttatgaa 1577161 ctcagaaagt gcagaggaag aagaaacggt gcagcctgaa gttacatacg aacagccgaa 1577221 agagcctgtg acgccagagc cgcgtattga accgaagcaa cagcagcagc cgccaaaaag 1577281 gcagggaaca gcaaaaaaag cagcgccagt tcaggtttca ccggtggaat tttccgcgtt 1577341 tgatccaaac gaagctgtac aagcccctat tcataatctg gatatgcttt tggatatccc 1577401 gctttcgatt actgttgagc ttggcagaac gaagagaagc gtaaaagaga ttttagagct 1577461 ttctgccgga agtattatcg agcttgataa attagccggt gagcctgtag atattttagt 1577521 taatcagcgt atcgttgcca aaggcgaggt cgttgtcatt gaagaaaact tcggagtgag 1577581 agtcactgac attttaagcc aggcagagcg cattaataat ttaaaataac gaaacacaag 1577641 gagagagata gattatggca catagaattt taattgtaga tgacgcagca tttatgcgaa 1577701 tgatgattaa agatattttg gttaaaaatg gttttgaagt tgtggcggaa gctgaaaatg 1577761 gagcacaagc ggtagagaaa tataaagagc attcacctga ccttgttact atggatatca 1577821 cgatgccaga aatggatggt attacagcat taaaagaaat taaacaaatt gatgcgcagg 1577881 caagaatcat catgtgttct gctatgggac agcaatcaat ggttattgat gccattcagg 1577941 ccggcgctaa ggatttcatt gtgaaacctt tccaggctga ccgtgtgctt gaagcaatca 1578001 acaaaacatt aaattaaagg gtgtacgact gttgaaaaag agtcaatatt ttattgtttt 1578061 tatttgtttt ttcgttttat tcagtgtaca tccgattgct gctgccgcgg cagactctga 1578121 taattcaact gtaaacgaat ggtttcaaaa gaaagatgaa aaaactgcag atcaatcaga 1578181 gcaaaagaaa gaaaaaacaa caaaaactgc tgatgagacg gagggagcgg ctgctccttc 1578241 tgtctcagct tttgattttg taaagatgat tttcgcttta ctgtttgtta tcgtgctgat 1578301 ttacgggctg gttaagctca tgaacaaaag aaatcggctc ctaaagcctt ttcaatatgt 1578361 tgaaaatatt ggcggcacat cggtcggtca gaacagatcc atacaattga tcaaggtcgg 1578421 gaaaagtgtg ctcgtcgtcg gtgtaggaga gacgatccag ctgctgaaag aaattgagga 1578481 tgaaaaagag attgaagtca ttctcagtca gcatgaagag gcaatgtcaa gcaaaataga 1578541 gtggcaaaag tttgtgaagc cgcttaagag ttctgaacat cagccgcagc aaaaactgcc 1578601 ttcattttca aaagcattaa aagagcaact tgaagagtta aaacaaaacc gttctgaagg 1578661 aaagaagaaa ggcccacgtc atcatgaatg agtttataaa tattttcagt tcaagcgatc 1578721 cggaaaacgt aagttcgact gttaaattac tattattgtt aactgtattt tcagtggcgc 1578781 ctggaatatt gattcttatg acttgtttta ctcgcatcgt cattgttctg tcatttgtca 1578841 gaacttcact tgcgacgcaa tctatgcccc caaaccaggt tctaatcggg cttgcgctgt 1578901 ttttaacatt ttttattatg gctcctactt tttcagaaat taataaagaa gcgctgaccc 1578961 cattaatgga caacaaaatc agcttggatg aagcgtatac gaaagctgag gaaccgatta 1579021 aagaatttat gagtaaacac acaaggcaga aggatctggc gctgtttatg aattacgcga 1579081 aaatggataa acctgaatca ttaaaggata ttccgttaac aacaatggtt ccggcttttg 1579141 ccatatcgga gcttaaaaca gcatttcaaa taggttttat gatttttatc ccttttttaa 1579201 ttatagatat ggtagtggcg agcgtcttga tgtcaatggg aatgatgatg ctgcctccag 1579261 ttatgatttc tctgcccttt aaaatattac tttttgtttt ggtagacggc tggtatttaa 1579321 ttgtgaaatc tttgcttcag agcttttagg gtaggtgcta aacgtgagtt cagaatttgt 1579381 aatttctatg gcggaaaaag ccgtatacgt aacgctgatg atcagcgggc cattattggc 1579441 tattgcttta ctggtcggtt taattgtcag catatttcag gcgacaactc aaatccagga 1579501 acagactttg gcgtttattc cgaaaatcgt ggcggttctc ctggctctca ttttttttgg 1579561 tccgtggatg ctgtcgacga ttctttcatt tacaacagag ctgttttcta atttaaatcg 1579621 ttttgcaggg taatgtagag atgaattcaa ttattgactt atttcctgct tttttattgg 1579681 tttttattag aatctctgct ttttttgtaa cgattccgct atttggacat cgaaatgtgc 1579741 cagctgttca tcgcataggt tttgcttttt ttcttgcggt catttgtttc agcaccattg 1579801 ataaaccgcc ctctttggag atagatgagc actatatgct tttggcgttt aaagaagctt 1579861 tggtcggcct atgtctgggt ttaattgctt atatgatgat tgccgcagtg cagattgccg 1579921 gctcgtttat tgattttcaa atgggatttt caatagcaaa cgttattgat ccgcaaaccg 1579981 gtgcacaaag tccgttgatt ggccagttta tctatacgat ggcacttttg tttatgctga 1580041 gtgtcaatgc ccaccatttg ttgctggatg gtatttacta cagctttcag tatatttcag 1580101 ttgatcaggc atttccgaat ttcggcgatg aaaagtttgc ctattttatt gcgaaaagct 1580161 ttaatgcaat gtttattatc gcttttcaaa tgtcagcgcc ggttgtggcc agtttgtttc 1580221 tagttgattt agcattaggt atcgtggctc gaactgttcc gcagttaaat gtatttgtgg 1580281 tcggtctgcc tttaaagatc gctgtcagtt tcattatgct cattgtatgt atgtccgtta 1580341 tcttcgtcgt tgtccggaat gttttcagtt taacgattga aacgatgcgg aatcttttag 1580401 cattggtcgg tgtttcttaa tgaagcttag agttgacctg cagttttttg cgggagagaa 1580461 gacagaaaaa gccactccga aaaaacggaa ggatacgcga aaaaaagggc aggtagccaa 1580521 aagctcggat gtcaataccg ccgtttcttt actggtaata ttcctttcgc ttattgcaat 1580581 tggtccgtat atgagagaca ggctgctgtc attcatagaa acattttata ccgaatcgct 1580641 cacaatgaag ctctcagaat caaatgtgca tacattgttt gtcagcttat taaaggatat 1580701 gggcatgata ctcgcaccga tcttgcttgt tgctcttgtt gcaggagtcg taagcaacta 1580761 tatgcaggtt gggttcttgt tttctgctga agtgatacag cctaagcttg aaaaactgga 1580821 tccgatcaaa ggctttaaac gaatatacag tatgagggcg attgtagagc tgattaaatc 1580881 aattttgaaa atcgtagtcg tcggttttgc ggcttttgct gtgctttggc tgcattatgg 1580941 agaaattctc cggcttcctc tcctgacacc cgaagaggca ctttctttcg tttcaaaact 1581001 cactttgtgg atgggactaa gcggtgcagg tgcattgttg attcttgctg gtctcgacta 1581061 tttatatcag agatttgact atgagaaaaa tatcaaaatg tcaaaacaag atataaaaga 1581121 tgagtacaaa aaatctgaag gagacccgat tatcaagtct aaaattaaac aaagacagcg 1581181 ggaaatggcg atgaggcgga tgatgcagga agttccaaaa gcagatgtca ttatcacaaa 1581241 cccgactcac tatgcgattg ctttgaaata tgatgaagaa aaaatggacg caccttatat 1581301 tgttgcaaaa ggcgtcgacc accttgcgtt aaaaatcagg aaaattgcta aagagcatga 1581361 tgtcatgatg gtagaaaaca gaccgcttgc ccgtgcgtta tatgatcaag tggaaattga 1581421 ccaggcagtg ccggaagaat tttttaaagt tttagcagaa attctggctt acgtatataa 1581481 aacaaaacaa aaagtatatt gaatttttcg atttaaaagg agagaaaaaa cagcatgtca 1581541 acaagagatt tatccgtttt aataagtgtt gtcctcattg tggcgatgct ggtgattcca 1581601 tttcctccat ggctgttaag tattttgatc attattaata tttctcttgc gttgatcgtg 1581661 cttctcacca caatgaatat gcaggaagcg cttcagtttt cgatttttcc gtcactgttg 1581721 ctgcttttga ccctatttcg tttgggcttg aacgtctcaa ctacccgttc aattctttca 1581781 cacggtgagg gaggtaaagt cgtcgagact ttcggaaatt tcgttgtcgg cggaaatgta 1581841 ttagttggac tcgttgtatt tatcatcctt attattattc agtttatcgt cattacaaaa 1581901 ggtgctgaac gtgtttccga ggttgcagca aggtttacgc tggacgcaat gccggggaag 1581961 cagatgagta ttgatgctga tttaaacgca gggatgatta ccgaacagga agcgaagcat 1582021 cgccgcgaaa aagtggcaag agaagcagac ttttatggag caatggacgg tgccagtaaa 1582081 tttgtaaaag gtgacgccat tgccggaatc atcattgtga tgatcaatat tattttcgga 1582141 atcgtgatcg gaatgcttca gcagggcatg tccattcaag aagctgcttc acactttacg 1582201 atgctgactg taggggatgg aattgtttcg caaatcccgg cactgttaat ttctacggct 1582261 acgggtattg tggtcacaag agctgcatct gaaggaaact tagggcatga cattacaggc 1582321 cagctgtttg cgtatccaaa gcttttatac gtcgcagcag ctacgatcat gcttttaggt 1582381 attttcactc cgatcggcat ccttctgacg gggccgcttg cgggattgct tgcttttggc 1582441 gcatatacac tatctaaatc aggtaaggaa aaagaagaag tggatgagat tcttgaggaa 1582501 gaggctgagg tggacgagct taaaagccct gaaagtgttg ttcagcttct gcatatagat 1582561 ccgatagaat ttgagtttgg atatggcctg ataccgcttg ctgatgccaa tcaaggcggt 1582621 gatttattag accgaattgt tatgatacgc cgtcagttgg ctttggaact cgggcttgtc 1582681 attcctgtcg tgcgaatcag agataatata gcgttgcagc ctaatgaata ccgattgaaa 1582741 attaaaggaa acgaagtagc aaaaggcgag ctgttgcttg atcattattt agcgatgtcg 1582801 cctactcctg aggacgatct cattgaaggg attgaaacag tggagccttc attcggactg 1582861 ccggctaaat ggattagcga agcggtaaag gatgaagccg acatgcttgg ttatacagta 1582921 gttgatcctg catcagtcgt ttcaacgcat attacggaga aaattaagca gcatgcccac 1582981 gaattgatcg gaaggcagga gacaaaacag ctgatcgatc acttgaaaga atcgtatcca 1583041 gtcctggttg aagaggttac gccgaatcca ttgtctgtcg gtgatattca gaaagtgctt 1583101 gctaagcttt taaaagaaaa agtttcaatt cgaaacttag taacgatttt tgaaacactt 1583161 gctgactatg ggaaattaac aacagattct gatctcttga cagagtatac aagacaagcg 1583221 cttgctaaac aaattacagc ccagtttgcc aaagaaaatg aagtgttgaa ggttgttact 1583281 tgttccggcc gtgtagaaaa agcaatagca gacggtgtgc agcagacgga acacgggaac 1583341 tatttatcac ttgaaccaga tatttcagaa agtatagtgc gctctgtcgc caaagaagct 1583401 gaacagctct cattacgtca ggaaaccgcg attcttcttt gctcgccgcc tgtcagaatg 1583461 tatgtgaagc agctactgga acggtacttc cctgatcttc cggtactctc ttataacgaa 1583521 cttgaggcga atgttgaggt acaaagcatt ggagtggtgg atatttaatg aaaataaaaa 1583581 aatttactgc tgcttcaatg caagaagcgg cacttctcat cagaaaagag ttaggtaatg 1583641 aagcggtcat attaaattcg aaaaaaatta aaaagcgaaa atggtttggc ctcgtcaaca 1583701 agcctgctgt tgaagtaatc gccgtattgg atcaggactt tcttgagaaa aaaacgcctc 1583761 agaaggcagc tgaaccgaaa caaacattaa aaactccggt cagcagtcca aaaatagagg 1583821 agagaacata tccccctcaa attccggcgc aacaggagct aggtgatttt tcagcatatc 1583881 aatctgtact tcctgagccg ctgcgaaaag cagaaaagct tttgcaagaa acagggatca 1583941 aagagtctac gaaaacgaac actctgaaaa aattgcttcg cttctctgtt gaagcaggcg 1584001 gcttgactga agaaaatgtt gtcggcaaac ttcaggaaat actatgcgat atgctgccct 1584061 cagcagacaa gtggcaggag ccaattcatt caaaatatat cgttctcttt ggttcaacag 1584121 gggctggtaa aacaactaca ctggctaaac tcgcagccat atctatgctt gaaaaacata 1584181 aaaaaatcgc ttttattaca acagatacgt atcgtattgc agctgttgaa cagttgaaaa 1584241 catacgctga actgctgcag gctcctctgg aagtttgcta tacaaaagaa gaatttcagc 1584301 aggcgaagga gctattttct gagtatgatc atgtgtttgt tgatacagct ggaagaaact 1584361 tcaaagaccc gcaatacatt gatgaactga aagaaacgat tccttttgag agcagcattc 1584421 agtcatttct tgttttatcc gcgactgcaa aatatgaaga tatgaagcat attgtcaaac 1584481 ggttttcatc cgtccctgtc aatcagtata tttttacgaa aatagatgaa acgacttcct 1584541 taggttctgt atttaatata ctggcagaat caaaaatagg tgtcgggttt atgactaacg 1584601 gccagaatgt gcctgaggat atacagactg tatctccact tggttttgtg aggatgctgt 1584661 gcagatgaac agatatgacc aagcagcaac tttacgggcg aaaatggaaa aacgtgagcg 1584721 cgttctgcca atggtttatt cacaaaaagc gaagacactt gctgtcatca gcggcaaggg 1584781 cggtgtcgga aaatccaata ttaccttaaa tatggcactt gcgctgcagg ataaaggtaa 1584841 gaaggtgctg ctcatcgacc ttgatatcgg gatggggaac attgatatat taataggaaa 1584901 ttcatcgtct gccacgataa tcgatgtttt aaccgatcgt aagcctttgc tgcagtcatt 1584961 atccgttggc ccaaagggtt tgcggtatat atcaggggga accggtcttg atgtgatgtt 1585021 tcagctcgat cagagaaaat ggacgttttt tgccaatgaa ctttctcatg cattaagcca 1585081 gttcgattat gtgctgtttg acatgggagc aggcttatca aaagatcaac tgccttttat 1585141 tttatcagca gaagatattt tgattattac aactcccgag ccgacggcca ttatggacgc 1585201 atacagcgct gtcaagcact tggttttgac agaaaataag ctttcaatga aggtggctgt 1585261 caatcggtgc cgtgaccaaa aggaagggct tgacgctttt gcccgcctct cccgtacaat 1585321 tcatatgttt ttggatgttc aggttcagtt tgccggttcc gtttctgacg atgtgatcgt 1585381 gagcaaagcg gttgtcgaac aggttccttt tttcataaaa agccctcagg caaaagccag 1585441 ccggtcagtc cgtattttag cggacgcctt gtttgaaaga gaagaaacga gacacaaaga 1585501 agacaaacag acatttattg agaaattatc ttctttttta atgaggaggg cttaatttga 1585561 ttcgtgtgct tgtagttgat gattcagctt ttatgagaaa aatgataagt gattttctga 1585621 ccgaagaaaa gcagatagaa gtaatcggaa ctgcgagaaa cggagaagaa gcgcttaaga 1585681 agattgaatt attaaaaccg gatgttatta ctcttgatgt tgaaatgccg gtcatgaatg 1585741 ggacagatac gctccgcaaa attattgaga tttataactt gccggtcatt atggtgtcta 1585801 gccagaccga gaaaggtaaa gaatgcacaa ttaattgttt ggagatcggt gcctttgact 1585861 ttatcacaaa gccatcaggc tcaatatctc tggatctata caaaattaaa gaacaactag 1585921 ttgagcgtgt cgtcgcggca ggactttccg gcaagcggaa acgtcctgtt tcccagacag 1585981 ttcggcccga acctattgtg cgtgctgtcg ttaagcctga attaagcaaa ccgaaacctg 1586041 gcacgggcag acaaattgtg tgtatcggca catcaacagg cggtccacgg gcgttacaaa 1586101 aggtgatacc gaagctccct aaggatttga acgcaccagt ggttgtcgtt cagcacatgc 1586161 ctgaagggtt tactgcttct ttggctgatc ggctgaatca tttatctgac attcaggtaa 1586221 aagaagcaaa agatggtgaa gcagctctta acggctgtgt ttacatagca ccgggcggaa 1586281 aaaacatatc cgttattaaa aacagcgaag gactccaggt tgtgcttgat aaccatgaca 1586341 caccaagccg tcataaacca tctgctgatt atttattccg ttctgtcggg aaactgacag 1586401 attatgaaaa agtagcggtt atcatgaccg gaatgggcag tgacggcact gctggactaa 1586461 aggacatgct aacagccggc aatgtgaaag ccattgcgga gtctgaagaa tcttgtgtcg 1586521 tatacgggat gccaaaagct gctgttaaag cgggtctcat tcatgagatt aaacatgtgg 1586581 aagatatcgc agcatccatc acaagctgtg tgaaaaaaga gagggtgtga ttcaaatgga 1586641 tatgaatcag tatttagatg tctttattga tgagagtaaa gaacatttac aaacatgtaa 1586701 tgaaaagctt cttcttttag agaaagaccc gactgatctt cagctcgtac atgatatatt 1586761 cagggctgcc catacattaa aaggaatgag cgcaacgatg ggctacacgg atttagcaca 1586821 tcttacccat ctgcttgaaa acgtgctgga tgcaatccga aacggagaca tggaagtcac 1586881 ctcagactgg ctggatattt tgtttgaagc tctggatcac ctggaaacaa tggttcagtc 1586941 tattattgat ggcggggatg gtaaaagaga tatctcagaa gtgagtgcca agcttgatgt 1587001 gaatggtgcg cacgctgaat ccgctgcctc cgctgaacct gcagaagcac agagttcagc 1587061 atctgattgg gaatatgatg aatttgaacg cacagttata caagaagcgg aggagcaagg 1587121 cttcaaacga tatgaaatca agatttctct gaacgaaaac tgtatgttaa aagcagttcg 1587181 tgtctatatg gtgtttgaaa aactaaatga agtcggagaa gtagccaaaa caattccaag 1587241 tgctgaagtg cttgaaacag aagattttgg aactgacttt caagtttgtt tcttaacaca 1587301 tcaatcagcg gaagacattg aacaattaat caatggcgtg tcggaaattg agcatgttga 1587361 agtcattcaa ggggctcctt taacatcagc tgaaaagcct gaagaatcta agcaagaaga 1587421 ttcaccagca gcagctgtac ctgcgaagca ggagaaacaa aaacagcctg ctaaaaacga 1587481 tgaacaggcg aagcattcag ccggcggatc taaaacaatt cgtgtcaaca ttgacaggct 1587541 tgattcttta atgaacttat ttgaagagct tgtcattgac cgcgggcgtc tcgagcagat 1587601 tgcgaaagag cttgagcata atgaactgac tgaaacggtt gaacgaatga cgagaatttc 1587661 cggagatttg caatcgatta ttctgaatat gagaatggtc ccggttgaaa ctgtttttaa 1587721 cagattcccg agaatgattc gccagcttca gaaagagctg aataaaaaaa ttgaactctc 1587781 gatcatcggt gcggaaactg aactggatcg tacagtaatt gatgaaatcg gagatccact 1587841 cgttcacttg atcagaaaca gtattgacca tggtatcgag gcgccggaaa cacgtttgca 1587901 aaagggaaaa ccggaatcag gaaaagttgt gcttaaagct tatcacagcg gcaaccatgt 1587961 ctttatcgaa gtagaggatg acggcgcagg ccttaatcga aaaaaaattc tggaaaaagc 1588021 gcttgagcgc ggggtcataa cggaaaaaga agctgaaacc ttagaagaca accaaattta 1588081 cgaattgatt tttgctccgg ggttctcaac tgctgaccaa atttctgata tttccggccg 1588141 cggtgtagga cttgacgttg taaaaaacaa actggagtct cttggcggtt cagtcagtgt 1588201 gaaatcagcc gagggtcaag gctctctatt cagcatccag ctgccgctta ccttgtctat 1588261 tatttcagtt ctgctgatta agttggaaga agagacattt gccattccga tttcttcaat 1588321 cattgagaca gcagttattg acagaaaaga cattttgcaa acgcatgacc gtgaagtgat 1588381 tgactttaga gggcatattg tccctgtcgt ttatttaaaa gaagagttta aaatagaaga 1588441 tacaagaaaa gatgcggaac agctccatat cattgtcgtg aaaaaaggcg acaaacctac 1588501 tgcatttgtg gtggactcct ttattggcca gcaggaagtt gtgctgaaat cactcggaga 1588561 ttatttaaca aacgtctttg caatttccgg agctactatt ttaggagacg gagaagtagc 1588621 gctcattatt gattgtaatg cactgattat ttaaccattc gaggaggtgt ctcacatgac 1588681 tgcagaaatt aaaacaggcg aaaaaatgat agtctttatg gtaaatggca aagaatatgc 1588741 catttccgtc actcaggtga aatcaattga aaaatggcaa aagccaacga gggtacctgg 1588801 cgtcgaacca tatatttgcg gggtaatcaa tttacgcggg gtggtgactc cggttattga 1588861 tttaagaaaa cgcctgaatt tgccagagta tgaaattaca gatgaaacac gaattatcat 1588921 tattgcttat cgtgatattg aagtcggctg gattgtggat gaagcgaatg atgtgattac 1588981 cgtacacgaa agtgaaatag aatctgctcc agaaggcgtt cagaaagata cggatgtgtc 1589041 gatcgaacag attgtgaaac aagagaacag actcttaaat attattgatg cgaacgcggt 1589101 tttggataaa gaatcatctc agtccgctgt gcccgatcaa gcttaatctt aaaggggtta 1589161 tgacatgagt atttttaatg gaatcaaaga agagcagatg gacattttgc gggaagtcgg 1589221 caatataggc gccggccact ccgcctctgc aatggcccag ctgttaaata gaaagataga 1589281 tatggaagtc ccatttgcaa agctgctgtc ttttgatgag cttgttgatt ttttcggcgg 1589341 cgccgatgtc ccggttgcca gcatcttttt aagaatggaa ggcgatttaa cgggttcaat 1589401 gttctttata atgccttttt ttcaggcgga gcagtttatc agagagctga ttggaaaccc 1589461 cgattttgac atagaggact taggtgaaga ccacatgagc tcatccgctt tgcatgaact 1589521 gggcaatatt ttagcggggt catatttaac agctttggcg gatttgacga aactccagct 1589581 ctatccaagt gttcctgaag tctcattgga catgttcgga gctgtgatca gcgaagggct 1589641 gatggagctc agtcaggttg gagaacacgc cattgttgtc gacacgtcaa tttttgacca 1589701 aagccatcag caggagctga aagcgcatat gtttatgctg ccggactatg attcatttga 1589761 aaagctcttt gtcgccttag gtgcatcatt atgagtacaa ctgaggctgt tgttataaag 1589821 gttgggattg ctgacgtgaa gatcgcccgc ttcccggata ccatccggac ctctggtttg 1589881 ggctcatgtg tggggctggt gctttatgat aaagaaaagc aaacggcggg tcttgttcat 1589941 gtcatgcttc cggattcgac gttatcgaaa actgccgagc tcaaccgggc taagtacgct 1590001 gacaccgccg tacagaccac gattgatatg ctgatagaag cgggatgccg gaaatttgca 1590061 ttaaaagcaa agctggccgg cggatcagag atgtttaaat ttaaatcgac aaatgatttg 1590121 atgaagatcg gaccgagaaa tgtattagcg ataaaagaac agctgtcttt atttaatatt 1590181 cctattatta gtgaagatac gggcggctca agcggccgga cgatagaatt tgaaccgaag 1590241 tcctgcatgc tgcatattcg aactgttaaa caaggtgaaa aaacgattta attaaggtat 1590301 tagggggata acaatgcaat ccttgaatta tgaagatcag gtgctttgga cgcgctggaa 1590361 agagtggaaa gatcctaaag ccggtgacga cttaatgcgc cgttacatgc cgcttgtcac 1590421 atatcatgta ggcagaattt ctgtcggact gccgaaatca gtgcataaag acgatcttat 1590481 gagccttggt atgcttggtt tatatgatgc ccttgaaaaa tttgacccca gccgggactt 1590541 aaaatttgat acctacgcct cgtttagaat tcgcggcgca atcatagacg ggcttcgtaa 1590601 agaagattgg ctgcccagaa cctcgcgcga aaaaacaaaa aaggttgaag cagcaattga 1590661 aaagcttgaa cagcggtatc ttcggaatgt atcgcccgcg gaaattgcag aggaactcgg 1590721 aatgacggta caggatgtcg tgtcaacaat gaatgaaggt ttttttgcaa atctgctgtc 1590781 aattgatgaa aagctccatg atcaagatga cggggaaaac attcaagtca tgatcagaga 1590841 tgacaaaaat gttccgcctg aagaaaagat tatgaaggat gaactgattg cacagcttgc 1590901 ggaaaaaatt cacgaactct ctgaaaaaga acagctggtt gtcagtttgt tctacaaaga 1590961 ggagttgaca ctgacagaaa tcggacaagt attaaatctt tctacgtccc gcatatctca 1591021 gatccattca aaggcattat ttaaattaaa gaatctgctg gaaaaagtga tacaataatg 1591081 aatttcatgg ttagcgagtg aaaaacatgt caacactatt atggctttta agctttatgc 1591141 tccacggcgt tcttctgtac gctgtcatta tcctgtatac gaggctcgct gcagtgaaag 1591201 aaacagaaaa acagcaaaaa cagatacttg aagagacgga aaacaccttg gcggcatttc 1591261 tgcttgaatt aaaagaagaa aatgagaaac tgatagaaaa taaagcttca tctgcaagtc 1591321 aatcagatga agaatcccaa aagtcaggcc ttcagacctc tgaaacatat caagagcggg 1591381 atccagtcca agaggcagag aatcttcctg aacatattga aggtctgatt acagaggttg 1591441 accgtcggga agagctcgta aacagtgagg tccaatcatt tgaagaccag gtcatagaat 1591501 tatatgaaca gggatattcg gcaagtcaaa ttgcccagaa aatgaagagc ggaaagacag 1591561 aaatcgagct atttttaaaa tttcgctcca aaggtgtaaa ggattcttga ttgtcggata 1591621 aagctgtgtt atattatgtc ttggtgttaa atacacacgc ttaacgattt atgcagaggg 1591681 tgctgcaggc ggcagttctg tacaaaaatg acctaagcgg aggaaaaaaa ccattatatt 1591741 aggaggaaat aacatgtcag tcatttctat gaagcaattg cttgaagctg gtgttcactt 1591801 cggtcaccaa acacgccgtt ggaacccaaa aatgaagcgt tacattttca cggagcgtaa 1591861 cggaatctac atcattgacc ttcaaaaaac agtcaaaaaa gtagaggaag cttacaactt 1591921 cactaaaaat cttgctgctg aaggcggaaa aatccttttc gtcggaacaa aaaaacaagc 1591981 tcaagattct gttaaagaag aagctcaacg ctctggcatg tactatgtca accaacgctg 1592041 gttgggcggt acattaacaa acttcgaaac aatccaaaaa cgtattaaac gtcttaaaga 1592101 cattgaaaaa atgcaagaaa acggtacgtt tgatgtactt cctaaaaaag aagtcgttca 1592161 attgaaaaaa gaattagagc gtcttgaaaa attcctaggc ggaattaaag atatgaagga 1592221 tcttcctgat gcattattca tcatcgatcc tcgcaaagag cgcatcgctg ttgcggaagc 1592281 tcgcaaatta aacatcccta tcatcggtat cgtagatact aactgtgatc cagatgaaat 1592341 cgatgttgtt atcccagcga acgatgacgc tatccgcgct gttaaacttc taacttctaa 1592401 aatggcagat gcaatcttag aagcgaagca aggcgaagaa gaagcggaag ttgctgaaga 1592461 aactgcacca gaaacagaaa caacaactgc gtaacctatt caaaaggtga taagagggac 1592521 tgccttttat cacctttttt caagaaaaat gtgtaatata catactcttg tttaaacata 1592581 taaggaggaa tacaaatggc aattactgca cagcaagtaa aagaactgcg tgaaaaaact 1592641 ggcgcgggca tgatggattg taaaaaagcg ttaactgaaa ctgacggaga tatggacaaa 1592701 gcaattgacc ttttaagaga aaaaggaatt gcaaaagcag cgaaaaaagc tgaccgtatc 1592761 gcagcagaag gttctactct tattaaaact gacggcaaca aaggcgttat cctagaagta 1592821 aactctgaaa ctgatttcgt tgcgaaaaac gaaggtttta aagagcttct taacacttta 1592881 gctgaccacc ttcttgcaaa cacgccagct gatgttgaag aagcaatggg ccaaaaaatg 1592941 gaaaatggct caactgttga agagtacatc acaagcgcag ttgctaaaat cggtgagaaa 1593001 atcactcttc gccgctttac agttcttaca aaagacgaca gctctgcatt cggtgcgtac 1593061 cttcacatgg gcggccgcat cggtgtatta actgttctca acggtacaac tgatgaagaa 1593121 actgcgaaag atatcgcaat gcacgttgct gcagttaacc ctcgttacat ttctcgtgat 1593181 caagtatctg aagaagaaac aaatcatgag cgtcaaatct taactcagca agccctccaa 1593241 gaaggcaaac ctgaaaacat cgtagcgaaa atggttgaag gccgtctgaa caaattcttc 1593301 gaagaaattt gtctattaga ccaagcgttc gttaaaaacc cagatgaaaa agtgaaacaa 1593361 gttattgcag cgaaaaacgc tactgttcaa acttttgtcc gctatgaagt tggagaaggc 1593421 atcgaaaaac gtcaagaaaa ctttgctgaa gaagtaatga accaagtgaa aaaataatgg 1593481 tgaaaagatt tcgcggctaa gtcgcgtctt ttcaggcagt ataggggaca cattttgtgt 1593541 tccctatttt taaaactata tttacaaacc tttttttctc ttgcataata gaaaacggca 1593601 atgtttacac ttggaggtta tcatggaaaa accaaaatac aaacgtatcg tattaaagct 1593661 tagcggggaa gcattggcag gagaacaggg aaatggaatt aacccgactg tcattcaatc 1593721 cattgcaaag caagtgaagg aaatcgctga gcttgaagtc gaagtggctg ttgttgtagg 1593781 cggcggcaac ttatggcgcg gaaaaacagg aagtgacctg ggcatggacc gcgcgactgc 1593841 tgactatatg ggaatgctgg cgacagtaat gaattcgctt gctcttcaag acagcttgga 1593901 aacactcgga atccagtcca gagtgcaaac atccattgaa atgagacaag ttgctgaacc 1593961 gtacataaga agaaaagcga tacgccactt agagaaaaaa cgtgtcgtta ttttcgctgc 1594021 gggcacagga aacccatatt tctcaactga tacgacagct gcactgcggg ctgctgaaat 1594081 tgaggcagac gttattttaa tggctaaaaa taacgttgac ggtgtgtata atgctgatcc 1594141 tagaaaagat gaatcagctg ttaagtatga atcactttct tatcttgacg ttcttaaaga 1594201 cggcctggaa gtcatggatt caacagcttc ctctttatgc atggacaatg acattccgct 1594261 tatcgtcttt tctattatgg aagaaggaaa tatcaaacgt gccgttatcg gtgaatcaat 1594321 cggaacgatc gtgaggggga aataacgtgt caaaagaagt attaactcaa acaaaagaaa 1594381 aaatggaaaa agcaattgct gcttatcagc gcgaattggc tactgtacgc gcaggccgtg 1594441 caaatccatc attattagat aaagtaacgg ttgaatatta cggagcgcag acacctttaa 1594501 atcagttgtc ttctattaac gtgcctgaag ctcgtatgct cgttatcacg ccatacgata 1594561 aaacagcaat cggtgatatc gaaaaagcga ttttaaaagc tgatttaggt cttacaccaa 1594621 caagtgacgg caatatgatt cgaattgcaa ttccggcact aacagaagag agacggaaag 1594681 aattagtgaa agttgtaaaa aaatatgctg aagaagcaaa agtagctgtt cgtaacgttc 1594741 gccgtgatgc taacgatgat ctcaaaaaac ttgagaaaaa cggagacatt actgaggatg 1594801 aactgcgtgc ttccactgaa gacgttcaaa aactgacaga tgaatatgtg tcaaaaattg 1594861 acagtgtcac aaaagacaaa gaaaaagaaa tcatggaagt ttaatgaaaa actatgtaca 1594921 atagataata gtgaaaagac cctctcatgt ttacaggggg tttttttgtt aatactgttg 1594981 attacattga ttatcagcag ggaatgtaac ctttttgggt gacggaggaa tctcatgctc 1595041 aacatactca aaaattggaa gaatcagcaa actgcggctt ccaacttaga acgttataca 1595101 aaagaagaca tacttaaggg agaaattccc gaacacatcg ccattatcat ggatggaaat 1595161 ggccgttggg ctaaaaaacg ctctcttccc agaattgcag gccaccatga agggatgaag 1595221 gtggtaaaaa ggaccacgaa gctcgcaaac gaattaggtg tcaaagtact gacattgtat 1595281 gcattttcaa cagaaaactg gaaaagaccg aaaatggagg tcgatttttt aatgaagctt 1595341 ccggaagaat ttttgaatac gtatcttcca gagcttgttg aggaaaatgt acaggttcgg 1595401 atcattgggg atgaaacggc tttgccggcg cacacattac gtgcgattga aaaagctgta 1595461 caggacacgg cgcaaaacga cggaatgatc cttaattttg ctcttaacta tggaggccgt 1595521 actgaaattg tcagtgctgc aaaatcactc gcggaaaaag tgaaggaagg ctctttgaat 1595581 attgaagaca ttgatgaatc gcttttttct acttatttga tgactgaatc tttgcaggat 1595641 cctgaacttt taattcgaac gagcggcgag ataaggctga gtaattttat gctatggcag 1595701 gttgcctaca gtgaatttgt ctttactgac gtcttgtggc ctgactttaa agaagatcac 1595761 ttcttgcagg cgttaggaga gtttcagcag agaggccgga ggtttggcgg aatttagagg 1595821 atggtggaca tgaaacaaag aattttgaca ggtgttctgg cagcaattgt atttttattt 1595881 ttggttattg tcgggaaatt gccgttcacc atattaattt atgctatggg cagtgtggcg 1595941 ctttttgaac ttttacggat gaaaaagctg aagctggttt cactgccggg tttgatcggt 1596001 cttttattat tgtggatgtt cttattacca agccagtatt cgttttttga agcggacggg 1596061 atttccaaaa tggaaatcgc tttatttgcg gtactgctat tgctgactta cacagtgttg 1596121 gtcaagaaca cctttacttt tgatgaagtc gggtttatta cgcttgcagc aatttacatc 1596181 ggaatgtgtt ttcattattt tatcgaaatc agaaatcttg accaatacgg attaacatac 1596241 attttttatg cgtgtgttgt catttggtcc accgattccg gtgcctattt tgtcggtaaa 1596301 tcgcttggga agcggaaact gtggcctgaa atcagtccga ataaaacagt ggaagggttt 1596361 gcaggcggaa ttgtcatcgc acttgtattg gcgacgattt ttcagcttgt tgcacaactt 1596421 ccgatcccgt atatctatct gctgttgatc acgctgtttt tgtctgtttt tggacaactg 1596481 ggagatttag tggaatccgc cttgaaaaga cattacgatg taaaggattc tgggaatatt 1596541 cttcccgggc atggcggtat attagaccgt tttgacagtt tcttgtttgt catgcctttc 1596601 ttgtactttc tgcttgccct tttttcataa aaaagtctaa tatgaatatg agactgatca 1596661 tgcagcaata agaataggag tagtggcaac tttgaaaaat atttgtcttt taggagcaac 1596721 aggatcaatc ggcgaacaga ctcttgatgt actgcgtgca catcaagacc aatttcagct 1596781 ggtatctatg tcgtttggca gaaatattga taaggccgtt ccaatgattg aggtctttca 1596841 gccgaagttt gtctctgtcg gtgatctgga tacatatcat aaattaaaac aaatgtcttt 1596901 ttcttttgaa tgccaaatcg ggctgggaga agaaggactg atagaagcag cagtgatgga 1596961 ggaggttgac attgttgtca acgctttgct tggaagcgtc ggtcttatcc cgacattaaa 1597021 ggcaattgaa cagaaaaaaa caattgcgct tgcaaataag gaaactcttg tcactgcagg 1597081 gcatatagta aaagaacatg ctaagaaata tgatgttccg ctgctgcctg ttgacagtga 1597141 gcattcagcc atttttcaag ctcttcaagg cgaacaggct aaaaacattg aacgcctcat 1597201 cattacggca tccggcggaa gttttcggga caagacgcgg gaggagctcg aatcagtaac 1597261 ggttgaagat gcattaaaac atccaaactg gtcaatgggt gcaaaaatta caattgattc 1597321 ggctacaatg atgaataagg gattagaggt gatcgaggca cactggcttt tcgatatacc 1597381 ttatgaacaa attgatgtgg ttttacataa ggagagcatc atccattcaa tggttgagtt 1597441 ccatgataaa agtgtgatcg cacagctcgg aactccggat atgagagtcc ccattcaata 1597501 tgcgctcact tatcctgacc gattgccatt accagatgcg aaaaggcttg aattatggga 1597561 aatcggcagc cttcattttg agaaagctga ttttgacagg ttccgatgct tacaatttgc 1597621 ttttgaatca ggtaaaatag gaggaacaat gccgacagtg ctaaatgcgg caaacgaagt 1597681 agctgtcgct gcctttttag ctggcaagat accgtttttg gctattgaag actgtatcga 1597741 aaaggcacta acccgccatc aattactgaa aaaaccgagc ctggcggaca ttcaagaagt 1597801 ggacaaagat acccggggat acgtcaattc aatactcaca taaggtggta tgttcgtgaa 1597861 tacagttata gcgtttatca ttattttcgg aacgctcgtt ttcttccatg aactgggcca 1597921 tttattgcta gcccaaagag cgggaattct ctgccgtgaa tttgcgatcg gcttcggtcc 1597981 aaagattttt tctttcaaaa aaaatgaaac agtttatacg atcaggctgc ttccggtcgg 1598041 cggatttgtt cgtatggccg gcgaagatcc ggaaatgatt gaggtgaaac ccggatacac 1598101 ggtcgggctt ctgtttaata aggaagatca agttgagaaa gtcatcatca atcaaaagga 1598161 aaaatatccg gatgctttag tcattgaagt ggaaacagcg gatctagagc atgacatgaa 1598221 gatcaccggt tatgaacagg ggaaagagga cgaactttcc agctttactg tcagcgaaac 1598281 atcctttttt attgtagacg gagaagaagt gcagattgcg ccgtataatc gccaatttgg 1598341 ttccaaacct gtatggcagc ggattaaagc aattgctgca gggccgatta tgaactttat 1598401 tttagcttac gtcattttag tgatgcttgg gctgattcaa ggcgtaccgt caaatgaacc 1598461 tatgctcggg cagctgacag acaatggacg ggcggctgaa gcagggctaa aagaagggga 1598521 ttatatccaa agcattaacg gagagaaaat gaggtcttgg actgacattg tctccgctgt 1598581 aaaagaaaac ccggagaaag aaatggacgt tgcagtaaaa agagataaca aaacgcttca 1598641 tatttcggtg actccggaag ctgttaaaga tgagaacaaa aaaacaatcg gacgtttcgg 1598701 ttcctatgcg ccgactgaaa aaggcgtact ctcagcggtt gcttacggcg cgacatcaac 1598761 agttgatgtc accaaagcca ttttaaccaa tctgagcaaa ttagtaacag gccaatttaa 1598821 actcgatatg ctgtcaggtc ctgtcggcat atatgacatg acagaccaag tggcgaaaac 1598881 agggatcgtg aacttatttc agtttgcggc gtttttaagc attaaccttg ggattgtcaa 1598941 cctgcttccg attccggcac ttgacggagg aagactgttg tttctattta ttgaagcgat 1599001 tcggggcaaa ccgattaaca gggaaaaaga agcatttgtt gtgtttatcg gagtagcttt 1599061 cttaatgctt cttatgctgg ttgtcacatg gaacgatatc cagcggctgt ttttgtaaac 1599121 gaaaagtaaa tcaatcagag gtgcgaagaa atgagacaaa gcttgacgct tattcctacg 1599181 ctccgtgaag ttccagctga tgccgaagca aaaagtcatc agcttcttct gagagcagga 1599241 tttatcagac agaatacgag cggggtatac agctatatgc ctcttgcgta taaggtgatt 1599301 caaaacattc agcagattgt tcgagaggaa atggagaaaa ttgatgccgt agaaatgctc 1599361 atgcccgcat tgcagcaggc agagacatgg caggaatcag gcagatggta tacgtatggt 1599421 cccgaactga tgagactaaa agaccgtcat ggccgtgaat ttgctttagg ggcaacgcat 1599481 gaagaggtta tcacttcgct tgttcgcgat gaggttaaat cttataagcg tctccctctg 1599541 actctttatc aaattcagtc taagttcaga gatgaaaaac gtcctcgctt cggtttgtta 1599601 agaggccgcg aatttattat gaaggatgcg tactctttcc atgcatctgc agagagcctg 1599661 gatgaaacgt atcaaaaaat gtacgaggcc tattctaata tttttgcccg ctgcggcatt 1599721 aatgtaagac ctgttatcgc tgattcaggc gcaatgggag gaaaggatac gcacgaattt 1599781 atggcacttt ctgcgatcgg agaggatacg attgcgtatt ctgatgaatc acagtacgcg 1599841 gctaatatcg agatggctga agttcttcac caggaagttc cttcagatga agagcctaaa 1599901 gctctagaga aggttcatac gcctaacgtg aaaacaatcg aagaactgac tgcgttctta 1599961 caggtttcgg ctgaagcgtg cattaagtca gtattgttta aagctgatga ccgttttgtc 1600021 ttagtgcttg taagagggga tcatgaagtt aacgatatta aagtgaaaaa cttgcttcat 1600081 gcagaagttg tagagcttgc tacacatgaa gaggtcattc agcagctcgg aacagagcca 1600141 ggctttgtag gccctgtcgg tattcatcag gatgtggaag tatatgccga tcaagctgtg 1600201 aaagcaatgg ttaatgctgt tgccggggca aatgaaggag atcatcatta taaaaatgtc 1600261 aatgtgaatc gtgacgcgca aattaaagaa tttgctgatc ttcgttttat taaagaaggt 1600321 gatccttcac cagacggcaa gggaacgatc cgttttgctg agggaatcga agtcggacaa 1600381 gtctttaagc tcggaacacg ctattcagaa gcgatgaatg cgacatattt agatgaaaac 1600441 ggacgcgcgc agccaatgct gatgggctgt tacggaatcg gtgtgtcaag aacgctttct 1600501 gctattgctg aacagcatca cgacgaaaaa ggcttaatat ggccaaaaag cgttgcgccg 1600561 tacgatcttc atattcttgc tttgaacatg aaaaacgatg ggcaaagaga gcttgctgaa 1600621 aagctgtatg ccgatttaaa agcggaaggc tatgaagtgc tctatgatga ccgtgctgag 1600681 cgtgccggcg taaaattcgc tgattcagat ttaatcggcc ttccaatccg catcactgtc 1600741 ggaaaacgag ctgacgaagg aatcgtcgaa gtgaaaattc gtcaaactgg tgagtcaact 1600801 gagatttcag tagacgaatt atctgcgttt atcagcaagc agtaatcacc ataacgattt 1600861 atcaaaaaac atgttaaaat agaaataata gaaggtacct cattgcctga ggtaccttca 1600921 cttatgatgt ttttagggag ggatactgtc ttaatggaac agttatcagt aaacagaagg 1600981 cagtttcaaa ttcttctgca gcagattaat atgacagatg ataccttcat gacatacttt 1601041 gaacatggcg agattaaaaa gctgacaatt cacaaagctt ctaagtcttg gcattttcat 1601101 tttcaattta aatctttgct gccttttcaa atatatgaca cattaacaac gaggctgacg 1601161 caatcgtttg cccacatagc aaaagtgaca tcttcaattg aagttcagga tgccgaggtc 1601221 agtgaaagta tcgttcaaga ctactggtca cgctgcattg aagaactgca gggcatttcg 1601281 ccgccgatta tcagtctttt aaaccagcaa aaaccgaagc tgaagggcaa taaactgatt 1601341 gtcaaaacca aaacagatac agaagcggct gcgctaaaga acaaatacag ttccatgatt 1601401 caagcagaat accgtcaatt tggctttccg gatcttcagc ttgatgctga aatatttgta 1601461 tccgagcaag aagttcaaaa gtttcgggag caaaagcttg cggaagacca agagcgggct 1601521 atgcaggcct tgattgaaat ggagaagaaa gataaagaaa gtgatgaaga ccaagcacca 1601581 tctggtcctc ttgttatcgg ttatcaaatt aaagataacg aggaaatccg aacacttgac 1601641 agcatcatgg acgaagaacg gagaattacg gtccaaggtt atgtgtttga tgtggagacg 1601701 cgcgagctga agagcgggcg cacgctgtgt atcttcaaaa ttacagacta tacaaatagt 1601761 attttgatca aaatgtttgc acgtgaaaaa gaagatgcgg cgctgatgaa gtctctgaaa 1601821 aaaggaatgt gggtaaaagc acgcggaagc attcaaaatg atacatttgt cagagacctt 1601881 gtcatgatcg caaatgacgt aaacgaaata aaagcaaaaa cccgtgaaga ttcagcacct 1601941 gaaggagaaa aaagagtgga attgcatctt cattccccaa tgagccaaat ggatgctgtt 1602001 acgggtatcg gaaagcttgt cgaacaggcg aaaaaatggg ggcatgaggc catcgctttg 1602061 accgaccatg ctgtcgttca atccttccct gatgcgtatt ctgcggccaa aaagcatgga 1602121 attaaaatga tttacgggat ggaagcgaat ctcgtggatg atggcgtgcc aattgcttat 1602181 aatgccgcac atcgtctgct cgaagaagaa acatatgttg tttttgacgt tgagacgaca 1602241 ggattgtctg ctgtatacga taccattatt gagctggctg cagtaaaagt aaaaggcgga 1602301 gaaattattg ataaatttga ggcgtttgcg aacccgcatc gtccgctttc cgccacaatc 1602361 atagagctga cagggatcac agatgatatg ctacaagacg ctccggatgt cgtagatgta 1602421 ataagagatt tcagagaatg gattggcgat gatattcttg tcgctcataa tgcaagcttt 1602481 gatatgggat tcttaaatgt agcctataaa aaacttcttg aagtcgaaaa agctaaaaac 1602541 ccagtcattg atacgcttga acttggacgt tttctctatc cggaatttaa gaaccaccgg 1602601 ttgaacacac tttgtaaaaa gtttgatatc gagctcacac agcatcaccg tgcgatctat 1602661 gatactgagg caaccgctta tttgcttctg aaaatgctga aagacgcagc tgaaaaaggt 1602721 attcagtacc atgatgagtt gaatgaaaat atgggtcagt ccaatgctta tcaaagatca 1602781 agaccgtatc atgcaacatt acttgccgtg aacagcacgg gacttaaaaa tttatttaag 1602841 cttgtgtcac tttctcatat tcattatttt tacagagtgc cgcgtattcc gagatctcag 1602901 cttgagaaat acagggaagg gcttctgatc ggttctgctt gtgacagggg agaggttttt 1602961 gagggaatga tgcaaaaatc gcctgaagag gtggaagata tcgcgtcatt ctatgattac 1603021 cttgaggttc agccgcctga agtgtatcgt cacttgctgg agcttgaact ggtccgtgat 1603081 gaaaaagcgc tgaaagaaat tattgcgaat atcacgaagc tgggggaaaa gcttaataaa 1603141 ccggttgttg ctacgggaaa tgttcattac ttgaatgatg aggataaaat ctacagaaag 1603201 attttaatat cctcacaagg cggggcaaat ccgctgaata ggcatgaact gccgaaagtg 1603261 catttcagaa cgacagacga aatgcttgaa gctttttctt tcttaggtga agaaaaagcg 1603321 aaggagatcg tagtcaccaa tacccaaaag gttgcttctt tagttgatga catcaagccg 1603381 attaaagatg atttatatac gccgaaaatc gaaggcgctg atgaagagat cagagaaatg 1603441 agctatcagc gtgcaagaag catttacggg gaagagctgc ctgaaattgt cgaagcgcgg 1603501 attgaaaaag agttaaagag tattattggc cacggatttg ctgttattta cttgatctct 1603561 cacaaacttg taaaacgttc actagatgac gggtatctcg ttggttcccg tggttccgta 1603621 ggatcttcat tagttgcgac acttactgag attactgagg taaacccgct gccgccgcac 1603681 tatgtttgtc ctgagtgcca gcattctgag ttctttaatg acggttctgt cggttctggt 1603741 tttgacctgc ctgacaagac atgccctcat tgcggaacgc ctttgaaaaa agacggccat 1603801 gatattccat ttgaaacgtt cttaggattt aaaggggaca aagtacctga tatcgatttg 1603861 aacttctcag gggaatatca gccgcaagca cacaattaca caaaagtatt gttcggagaa 1603921 gacaatgtat atcgtgcggg aacaataggc acggtggcag aaaaaacagc ctacggttat 1603981 gtaaaaggct atgccggaga caacaatctt catatgcgcg gtgccgaaat agatcggctc 1604041 gtacagggat gcacaggtgt aaaacgtaca actggacagc accctggcgg tattatcgta 1604101 gttccggatt atatggatat ttatgatttt tcaccgatcc agttcccggc agatgccaca 1604161 ggttcagagt ggaaaacgac tcattttgat ttccactcca tccatgacaa cctgttaaaa 1604221 cttgatattc tcggacacga tgacccgact gttattcgga tgcttcaaga cttaagcgga 1604281 atagatccga aaacaattcc gacggatgat cctgaagtga tgaagatctt ccagggaacc 1604341 gaatcactcg gtgtgactga agaacagatt ggctgtaaaa cgggcactct tggaattcct 1604401 gaattcggaa cccgatttgt ccggcagatg cttgaagata caaagccgac cactttttct 1604461 gagctcgttc agatttcagg cttgtctcac ggaactgatg tatggcttgg caatgcacag 1604521 gagctcatcc acaataatat ttgtgagctg agtgaggtta tcggctgccg tgatgacatt 1604581 atggtttatt taatctatca aggccttgag ccgtcccttg cctttaaaat catggaattc 1604641 gtgcgtaaag gaaaaggatt aacgcctgaa tgggaagaag aaatgaaaaa taacaatgtc 1604701 ccagactggt atattgattc ctgtaaaaag attaaataca tgttcccgaa agcccacgcc 1604761 gcggcatatg tcttaatggc agtccgcatt gcttacttta aagtgcatca tgctcttttg 1604821 tattatgcgg cttattttac cgttcgtgca gatgactttg atattgatac aatgatcaag 1604881 ggctctacag caatcagagc ggtaatggag gatataaacg ctaaaggact tgatgcttca 1604941 ccgaaggaaa agaaccttct gactgtttta gaattagcgc ttgagatgtg tgagagaggc 1605001 tattcattcc aaaaagtcga tttatatcgc tccagcgcca cagagtttat tattgacggc 1605061 aacagtctta ttccgccgtt taactctatt ccagggttag ggacgaacgc tgctttgaac 1605121 attgtaaaag ctcgcgaaga aggcgaattc ctctcaaaag aagatttgca aaagagaggg 1605181 aaagtatcaa aaacgatttt agagtactta gatcgccatg gctgtctgga gtcactgcct 1605241 gatcaaaacc aattgtcact gttctaatat ggaaagcaga atttctcaga aattctgctt 1605301 ctatgcatac ataagcgcaa aaagtgccat cgtaatatta gagtttctgt cacttgctta 1605361 ggtatgaagg taagcgtata tccatttgca ataaaaatat ggttatggta tagttttatt 1605421 ggaaatgcta acgattaccg aggcaaagag tggggaaacc cgctcttttg tattgaacag 1605481 gagaattttg tctcgacatg ttcatcgttt actttttagc ccctgctctt ttgaagcagg 1605541 gtttttatgc agagtgacga gacgaatatg agatcgacag cacaaggagg aagaacatga 1605601 gcaaaaaagt gactgacacc gttcaagaaa tggctcagcc aatcgtagac agccttcagc 1605661 tggaactcgt tgacattgaa tttgtcaaag agggccaaag ctggttcctt cgcgtgttta 1605721 ttgattccga tgacggtgtg gatattgagg aatgtgccaa agtaagcgaa gctttaagcg 1605781 aaaagcttga tgaggcagac ccaatcagcc aaaattactt tcttgaagtc tcatctccag 1605841 gagctgagcg tccgctaaag aaaaaagccg atttcgaaaa atcactagga aaaaacgtat 1605901 acattaagac gtatgagcct attgacggcg taaaagtgtt tgaaggtgaa ctggctgaat 1605961 ttgatggaca aacagtgaca gttgagatca cgatcaaaac aagaaagaaa cggatcaata 1606021 ttccgtatga aaagatagct aatgcaagat tagctgttac attctaatga atacaaatgt 1606081 tttaaggggg gagaccgtta aatgagcagt gaattattag atgctctcac gattcttgaa 1606141 aaagaaaaag gcatcagtaa agaaattatc atcgaagcaa tcgaagctgc gttaatttct 1606201 gcttataagc ggaattttaa tcaagcgcaa aatgtacggg tggatctaaa ccgtgaaact 1606261 ggctccatcc gtgtatttgc aagaaaagat gtcgttgacg aagtatacga ccagagatta 1606321 gaaatctcaa ttgaagaggc acagggcatc catccggaat atatggtcgg cgatgtcgtc 1606381 gaaatcgaag ttacacctaa ggatttcggg cgcatagctg ctcaaacagc gaagcaggtc 1606441 gtcacacagc gtgtgcgcga agctgagcgc ggtgtgattt attctgaatt tatcgaccgt 1606501 gaagaagaca tcatgacagg gatcgtccag cgtctggaca ataaatttat ctacgtgtct 1606561 ttaggcaaaa tagaagcctt gctgccggtt aatgagcaaa tgccgaatga aagctacaag 1606621 ccccatgacc gcattaaggt atatatcaca aaagtagaaa aaacaacgaa gggtccgcag 1606681 atttatgtgt caagaacaca tccaggcctg ttaaagcgtt tgtttgaaat tgaagtgcct 1606741 gaaatttatg atggaactgt cgagctaaaa tctgttgcca gagaagccgg cgaccgttcg 1606801 aaaatttctg ttcgcacaga tgatcctgac gttgatcctg tcggttcatg cgtagggcct 1606861 aaaggccagc gtgtgcaagc aatcgtcaat gaattaaaag gtgaaaaaat tgacattgtc 1606921 aactggtcca gtgatcctgt agaatttgtc gcgaatgcgc tcagcccttc caaagtgctt 1606981 gatgtcattg ttaatgaaga agaaaaagcg acaactgtta ttgttcctga ttaccagctg 1607041 tctctggcaa ttggaaaaag aggacaaaac gcacgcttag ctgctaaact gacaggctgg 1607101 aagattgata ttaagagcga aacggacgca agagaacttg gaatctatcc gagagaactt 1607161 gaagaagatg atgagccgct ctttacggag cctgaaactg ctgaatcgga tgaataagag 1607221 gtgactttag gtgaataaac acaaaaagat cccattacgc aaatgtgtag tgactggtga 1607281 aatgaagcct aaaaaggaac tgatccgagt tgtacggtcg aaagaaggcg aaatctcagt 1607341 agacccgacc ggaaaaaaga atgggcgggg tgcttattta acgctggata aagagtgcat 1607401 cttagcagca aaaaagaaaa acactttgca aaatcaattt caatcacaaa tcgatgacca 1607461 gattttcgat gaattgctgg aactggcgga aaaggtgaaa aaataaaatg tctggaatgg 1607521 aatggtttcc cttgctgggt ctggccaatc gagctcgtaa ggtcgtgtca ggcgaagact 1607581 tggtaataaa agaaatcagg aatgcgcgtg caaagcttgt cctgcttaca gaggatgcat 1607641 catctaacac agcaaaaaaa gtaactgaca agtgcaatta ttataaagtc ccttataaaa 1607701 aagtcgagag tcgcgcggtt cttggacgct ctatcggtaa agaagcccgt gtcgttgtcg 1607761 ccgtcactga ccaaggtttt gcgaataagc tgatcagctt gctcgattaa tatttttggg 1607821 ggtgaacgaa tggctaaaat gagagtatac gaatatgcaa aagcgttaaa tgtttcaagt 1607881 aaggaaattt tgaccgcact gaagaacatg gatttagaag tgaataatca catggccatg 1607941 cttgaagaaa aggccattaa aaagctagat gccaaatata aaaaaggcgg cgcagctgct 1608001 aaatctcaaa agccagcaga aacgaacaaa aacaaacagc cacaaggggt taatcagcaa 1608061 tcagctggaa atcaaccaaa taaaattcga gacggaaaga agaatgacgt gcagaataat 1608121 caatttaaca aaaacaagaa gaataacaac aacaaaaaaa ataaacgcaa caacaacaat 1608181 aataaaaacc aacatcagca aaagcctgta aagccgaaaa aagagcttcc tgagaaaatt 1608241 acattctctg gcactttaac agttggcgca cttgctgaag agcttggcaa agagccttca 1608301 gaactcatta aaaagctgat gcttcttggc gtaatggcaa ccattaacca agagcttgat 1608361 aaagacacaa tcgaactcat tgcatcagaa tatggtgttg aaacagaaga ggtcattgtg 1608421 cttgaagaaa cagagctgga aaaatacgaa gagcctgata atgaagagga tcttgaaatt 1608481 cgtcctcctg tcgtgacaat catgggccac gttgaccatg ggaaaacaac gcttcttgac 1608541 agcatccgta aaacaaaggt tgttgaaggg gaagcaggcg gaatcactca gcatatcggc 1608601 gcttatcaaa ttgaagagaa cggcaagaaa atcacgttct tggatacacc gggccacgcc 1608661 gcatttacaa caatgcgcgc acgcggtgca gaagtaactg atattacgat tcttgtcgta 1608721 gctgccgatg acggtgtcat gccgcaaaca gttgaagcga ttaaccatgc aaaagcagca 1608781 gaggttccaa tcatcgttgc tgtgaataaa atagataaag aatccgcaaa ccctgaccgt 1608841 gtaatgcaag aactgacgga atacggactt gtccctgaag cttggggcgg agaaaccatt 1608901 tttgtgccgc tttccgcttt aactggaaaa ggcattgatg agctcgttga aatgattttg 1608961 cttgtcagtg aggtagagga actgaaagcg aatccgaatc gtcaggcaaa aggaacggtt 1609021 attgaagctg aactcgataa aggcagaggg tcagtcgcga cgttgctcgt acagactgga 1609081 acactgcatg tcggtgatcc gatcgtagtc ggcaatacat ttggccgtgt ccgtgcaatg 1609141 gtcaacgaca ttggccgccg tgtgaaaact gccggcccgt caactccggt tgaaattacc 1609201 ggtttgaatg atgtccctca agcgggagac caattccttg tctttaagga tgaaaaaaca 1609261 gctcgttctg tcggtgaagc ccgtgcttcg aaacagcttg aagagcagcg cagcgataaa 1609321 gcgaagctca gtcttgatga tttatttgag caaattaagc aaggtgatgt aaaagacatc 1609381 aacctcatcg taaaagctga cgttcaagga tctgctgaag ctttaacggc tgcacttcaa 1609441 aaaattgaag tagaaggcgt taaagtgaaa atcatccata caggcgttgg tgcgattact 1609501 gaatcagaca ttatcttggc atctgcttcc aatgcaattg ttatcgggtt taatgtgaga 1609561 ccggacggaa atgctaagag tacggctgaa gctgaaaatg tagatattcg acttcaccgt 1609621 atcatttaca aagtaatcga cgagattgaa gctgccatga aaggtatgct tgatcctgaa 1609681 tatgaagaaa aagtaattgg tcaagtagaa gtacgccaaa cattcaaagt atctaaaatc 1609741 ggtacaattg ccggcggata tgttactgaa ggaaccatta cgcgcgacag cggcctccgt 1609801 ttaattcgtg acggcgtcgt catctttgaa ggcgaagtag atgttctgaa acgctttaaa 1609861 gacgatgtga aagaagtttc acaaggctat gaatgtggta ttacaattaa gaaatacaat 1609921 gacattcgtg aaggtgacat ccttgaagcg tttgtcatgc aagaaattga aagaacgtga 1609981 tcggatttgc ggagtgtgaa tgcatcattt atgatgcagg atcgctaaaa gaaaagcgtg 1610041 ccgttctgaa gcggatttta accagggttc aaaacaagtt caatgtttcg atttcggaga 1610101 ttggctatca ggacacctgg caaagaacca gcttcggaat cgccgctgtt tcttcctctc 1610161 gcgttcaaac agaaaaagaa ctgcagcgcg tcctagcgtt tatcgattct tttcctgaaa 1610221 ttgaacggac gatcactagg acagagtggt tttaacttag aggtgattga attgagtatg 1610281 agagcaaacc gtgtcggcga gcaaatgaaa aaagaactcg gtgatattat cagccgcaag 1610341 ctgaaagacc cgagaattgg ttttctgaca gtaacggatg tacgtgtatc aggtgatttg 1610401 caaattgcaa aggtgtatat ctcggttctc ggtgacgaga aaaaacggga agaagcgctg 1610461 aaagggctgg caaaagcgaa aggatttatc cgatccgaaa tcggcagccg catcagactt 1610521 cgaaaaacgc ctgaaattga atttgagttc gatgaatcaa tcgattacgg gaatcggatc 1610581 gaaacactga ttcacgaatt acattcagag aaaccatctg aataaaaaaa gagaggatag 1610641 gcgtatatcg tctgtcctct ttcttcgttt ataagaaaaa aactcaaaag aaggagtgaa 1610701 aggcaaatgg ttaacggagt tctcctttta cataaacctg ttggcatgac atcgcacgac 1610761 tgtgtcatga agatccgaaa gctgttaaaa acaaaaaaag taggacatac aggaacgctc 1610821 gatccggaag tatcaggcgt gcttccgatt tgtgtaggaa gagcgacaaa aatagtcgaa 1610881 tacttaactg aaaaatctaa aacgtatgat gcagaaataa cattgggctt ttcaaccaca 1610941 acagaggatc aaaccggaga aacggtggaa acaaagcctg tcaatcacga cattgataaa 1611001 gcggatgtag aaaaggtttt aaacagttta aaggggaaac aagaacaaat tccgcccatg 1611061 tattccgctg taaaagtaaa cggcaaaaaa ttatacgaat acgcaagagc agggattgaa 1611121 gtagaacgtc cgaaacgtat gataaccatt gaagacattg ccctgacaac agagattaaa 1611181 catcatggag aaaccgcaag cttccggttt acagtgactt gctccaaagg gacctatgta 1611241 aggacgctgg cggtcatgat cggagaaaag ctcggatatc cggcccatat gtctcattta 1611301 atccgtacgg catccggaga tttttctctc gacgaatgct ttacttttga tgaactcgaa 1611361 gcacaggccc aatccggaac cgtggaagag catacagttc ctattgaacg tgcgctcaat 1611421 catttgccga aatggatcat aagtgataca ttagctaaga aagtagaaaa tggggctttg 1611481 cttgagacgc ccgagcagtt ttctgaaatg acaagtggag accgtattgc cgtctttact 1611541 gaatccggaa cctgcttggc gatctatttc cctcatcctg caaaaaaagg gctgttaaag 1611601 ccggcaaaag tattgatgca aaaaagcgaa caatagaaaa aaggtgaccg ttctgtgaag 1611661 acgatacata ttacacatcc tcatcattta ataaaagagg agcaggcaaa atcagtgatg 1611721 gcgttaggtt attttgacgg cgttcatctc gggcatcaaa aggtaatcgg cacagcgaag 1611781 caaatagccg aagaaaaagg tctgacatta gctgtgatga cctttcatcc ccatccttct 1611841 cacgtgttgg gcagagataa ggaaccaaag gatctgatta cgcctcttga agacaaaata 1611901 aaccaaattg aacaattagg cacagaagtt ctgtatgtcg ttaaatttaa tgaagtgttt 1611961 gcttctcttt ctcctaagca gtttatagac cagtatatta tcggccttaa tgtgcagcac 1612021 gcagtggcag gctttgactt tacgtacggc aaatacggca agggaacaat gaagaccatg 1612081 ccggatgatt tagacggaaa agctgggtgc acaatggtag aaaaattaac ggagcaggat 1612141 aaaaaaatca gttcttcgta tatccgtacc gcgcttcaaa acggagatgt tgaattggcg 1612201 aatgtcttgc ttggacaacc ttattttatt aaaggaattg tcattcatgg tgataaaaga 1612261 gggcggacca tcgggtttcc gacagcgaat gtcggtttaa ataacagcta tatcgttccg 1612321 cccacaggtg tatatgccgt aaaagcggaa gtgaacggcg aagtttacaa tggcgtttgc 1612381 aatattggct ataagccaac gttttatgaa aagcgccctg aacagccttc catcgaggtc 1612441 aatctgtttg atttcaatca agaggtatat ggagccgcta taaaaatcga atggtacaaa 1612501 cggattcgga gcgagcggaa attcaatggc atcaaagaat taactgagca aattgagaaa 1612561 gataagcagg aagccatccg ttatttcagc aatttgcgga aataacttgc aacgcacgca 1612621 aattttattc taaaatattt gcatataggc acgattttta gtatgatagt tttcgtagtc 1612681 ttaaaaccat tgcttggcaa tccgaagtca ccgacggttg ctaggtaact ggggctaaat 1612741 atgatttgga ggtgaaacag gatggcaatt actcaagagc gtaaaaacca actcatcaat 1612801 gagttcaaaa cacacgaatc tgatactgga tctccagaag ttcagatcgc tatcctaact 1612861 gactcaatta acaacttgaa cgagcattta cgtactcaca agaaagacca ccactcacgt 1612921 cgcggtcttc ttaaaatggt aggtaagcgt cgtaatcttc ttacgtatct gcgtaataaa 1612981 gacgtaactc gttaccgtga gttaattaac aaactaggct tacgtcgata atcgtaaaaa 1613041 gcgggaggat tcccgctttt ttatcgtatt aaagcgaaat ttcttataac aaatcattga 1613101 aatcctttta catactactt tgacattgat atgttcaatt catttcgttc ataataggag 1613161 taattgatta tttcacacaa cgaagagagg agttcgtaat tgtatgggac aagaaaaaca 1613221 tgtctttacc atagattggg ccggaagaac gcttaccgtt gaaaccggcc agcttgccaa 1613281 acaggcaaat ggtgctgtga tgatccgcta cggtgataca gcagtactta gtacagcaac 1613341 cgcttcaaaa gaacctaaac cgcttgattt cttccctctt actgtaaact atgaagaaag 1613401 attatatgcg gtagggaaaa ttccgggcgg atttattaaa agagaaggac gtccaagtga 1613461 aaaagcggtt cttgccagcc gtttaattga ccgtccgatc cgtcctttgt ttgccgatgg 1613521 attccgtaat gaagttcaag tcatcagcat tgtcatgagt gttgaccaaa actgctcttc 1613581 agaaatggct gccatgttcg gttcatctct tgcactttct gtatcggata ttccgtttga 1613641 aggaccgatt gcaggggtta ctgtcggacg cattgatgat caatttatca ttaacccgac 1613701 agtcgatcag cttgaaaaaa gcgatatcaa tcttgtcgtt gccggcacga aagatgcgat 1613761 taacatggta gaagcgggag cggacgaagt tcctgaggaa atcatgcttg aggccattat 1613821 gttcggccat gaagagatta aacgcctgat tgcattccaa gaagaaattg ttgcagcagt 1613881 cggcaaagag aaatctgaaa ttaagctctt tgaaattgat gaagagctta atgaaaaagt 1613941 aaaagctttg gcagaagagg atctgctgaa agccatccaa gttcatgaaa agcatgcccg 1614001 tgaagatgcc attaacgaag tgaagaacgc agttgtggca aaattcgagg atgaagaaca 1614061 tgatgaagac acaatcaagc aagtgaagca gattttatcc aagcttgtga aaaatgaagt 1614121 tcgccgcctg attactgaag agaaagtaag accggacggc cgcggtgtcg atcaaatccg 1614181 tccgctctct tcagaggttg gcctcttgcc aagaacgcac ggttcaggtc tatttacaag 1614241 gggacaaact caggccctca gcgtatgtac gctaggtgct ctgggagatg tgcaaatcct 1614301 tgacggctta ggtgtcgaag agtcgaaacg gtttatgcat cattacaact tcccgcaatt 1614361 cagcgttggg gaaacaggac cgatgcgcgg accgggacgt cgtgaaatcg gacacggagc 1614421 actgggtgag cgtgcgcttg agccagttat tccgtctgaa aaagacttcc cttatactgt 1614481 ccgtcttgtt tcagaagtgc ttgaatcaaa cggttctaca tctcaagcaa gcatttgcgc 1614541 aagcacactt gcaatgatgg atgccggtgt accgattaaa gcgccagttg ctggtattgc 1614601 gatgggtctt gtcaaatcag gcgaacatta cactgtcttg actgacatcc aaggcatgga 1614661 agacgcgctc ggagatatgg actttaaagt agcgggaact gaaaaaggcg taacggccct 1614721 gcaaatggac attaaaattg aaggcctttc cagagagatt cttgaagaag cgcttcagca 1614781 ggcgaaaaag ggcagaatgg aaatcctcaa cagcatgctt gcaacattaa gcgaatcaag 1614841 aaaagagctt tctcgatatg cgcctaagat cttaacaatg accattaatc ctgataaaat 1614901 ccgcgatgtc atcggaccaa gcgggaaaca aatcaataag atcatcgaag aaaccggtgt 1614961 taaaattgat attgagcagg acggcacaat ctttatttcc tctacagatg aaagcggcaa 1615021 ccaaaaagcg aaaaaaatca tcgaagacct tgtgagagag gttgaagtcg gccaacttta 1615081 cctaggtaaa gtgaaacgga ttgaaaaatt cggggctttc gttgaaattt tcagcggaaa 1615141 agacggtttg gtgcacattt cagagcttgc gcttgaacgc gtagggaaag ttgaagatgt 1615201 tgtgaaaatc ggagacgaga ttcttgtcaa agtcactgaa attgataaac aaggacgagt 1615261 gaatttatcc cgcaaagcgg tgctccgtga agagaaagaa aaagaagaac aacaatctta 1615321 aatgaaaaca taaaaggagc ctgggagacc cggcttcttt attttgaagc ttttcaaaag 1615381 caggcgggtt ctaccttgtc cttctccttc ataatgtgag gtgagggggg gacagaacat 1615441 gtacaaaaaa tttgtaccgt ttgccgtttt tttatttctt ttttttgtct catttgagat 1615501 gatggaaaat ccgcatgcac ttgattatat aggggcaatg aaaaaagata cggtgactgt 1615561 cacggcgtca aaagacccgt tatatgaaga attgcttcaa aaagcgccgg agtacgaagt 1615621 taagccccag aatgcaagaa ttgataaagt gtggaaaagc attccaggct acaatggatt 1615681 aaaggtcaat attgaacaat catataaaaa aatgaaacag catggtaagt ttcgggaaaa 1615741 agatttggtg tacagtcaag taaaaccaag tgttcatctt gagtcacttc agcctgagcc 1615801 tatttataaa ggaaatcctg acaaaccgat ggtggctttt ttaatcaatg tggcatgggg 1615861 aaatgagtat ttggaaaaaa tgcttcctat tctgcaaaag caccaggtta aagctacgtt 1615921 ctttttagaa ggcaattggg tgagaaacaa tgtacagctc gctaagaaga ttgcaaaaga 1615981 cggacatgaa atcggaaatc attcatacaa tcatccggat atgagcaaac tgactacagg 1616041 aagaatttcc gagcagctcg acaagactaa tgaacaaata gaacaaacga tcggcgttaa 1616101 gccaaagtgg ttcgctccgc caagcggaag tttcagaaaa gcggttatcg acattgcagc 1616161 agagaaacag atgggaacag tcatgtggac agttgataca atcgattggc aaaagccggc 1616221 tccgtctgta cttcagacga gagtgttaag caagatacat aatggtgcca tgattttaat 1616281 gcatccgact gaccctacgg cggaaagtct tgaagcgctg attacacaga taaaagacaa 1616341 aggatatgcg cttggaacag tcactgaact aatggatgaa acaagactat tgaagtaaca 1616401 gatgaaggca gcttgtcttt gaataggagg aacaaatttg attaaacgat atacgtgtca 1616461 aaatggtgta agaattgtgc tggaaaataa cccgacagtc cgttctgttg cgatcggcgt 1616521 atggatcggc acaggttcga gacatgaaac gccggagata aacggaattt ctcacttttt 1616581 agagcacatg ttctttaaag ggacgagcac aaaatctgca cgcgagatag cagaatcttt 1616641 tgatcgtatt ggcggccagg tcaatgcgtt tacttcaaag gaatatacct gctactatgc 1616701 aaaggtgctt gacgagcatg cgaattacgc gctggacgta ttagcagata tgttctttca 1616761 ttcaacgttt gatgaaaacg agctgaaaaa agagaaaaat gtagtatatg aagaaattaa 1616821 aatgtatgaa gatgcgccgg acgacattgt acatgattta ttgagcaaag ccacttacgg 1616881 caatcattct ttaggctacc caattttagg aacggaagaa acgcttgctt cctttaacgg 1616941 tgactctctc agacaataca tgcatgatta ttatacgccg gaccgagtgg tgatttcggt 1617001 agcgggcaat atatctgaca gttttatcaa agatgtagaa aaatggttcg ggtcatacga 1617061 ggcgaaaggc aaagcgacag gccttgagaa gcctgagttc cacacggaaa aactgacgag 1617121 aaaaaaagaa acagagcagg ctcatttgtg ccttggattt aaaggcttag aggttggcca 1617181 tgaacgtatt tatgatttaa tcgtcctcaa caatgtgctc ggaggcagca tgagcagccg 1617241 gctgttccaa gatgtgcgtg aagataaagg acttgcttat tctgtttaca gctatcacag 1617301 ctcatatgag gacagcggaa tgctaacgat ttacggcgga acgggtgcaa atcagcttca 1617361 gcagctgtcg gaaacaattc aagaaaccct ggccacatta aaacgtgacg gcattacctc 1617421 gaaagaactg gaaaacagca aagagcaaat gaagggaagc ttaatgctga gcttagaaag 1617481 cacaaacagc aaaatgagcc gaaacggaaa aaatgaactg ctgctcggca aacataaaac 1617541 attagatgaa attatcaatg aattaaacgc cgtgaactta gagcgtgtta atggccttgc 1617601 cagacaattg tttaccgaag actatgcatt agcacttatc agcccttccg gcaatatgcc 1617661 gtcttaaaaa ggaaagcctg ccccataatg gagcaggcat tttttaatcc ctttcatcat 1617721 acatagtaca agggggtgac agacatgcgg ctcagtgaat tatcgggaaa ggaaattgta 1617781 gacatcaaaa gagctgaacg gctcggagtg ctcggccaga ccgatttgga aatcaatgaa 1617841 caggatggac agattacagc actcctcatt cccacagtta agtggtttgg tttgagaaag 1617901 caaggtcatg acattcgtgt cccatggcac catattcaaa agatcggttc agatatgatt 1617961 atattagatg tacctgagga aatgcctcct cgacaagagt aaatagccca attgactgtg 1618021 aagcgggctc taaagaaaac atctgaaaca tcggctgccg gagccgatgt ttttttatat 1618081 ggaaaaagcg catcttttat attcaccggt atttcctttt gatcataaga tgaaggggag 1618141 cttaacaact agagatccag tatatacaaa gaaggtgaac gtttagaatg ttaaccggat 1618201 tgaaaattgc agttatcggc ggtgacgcaa gacagctcga aattataaga aagctcactg 1618261 aacagcaggc tgacatctat cttgtcggtt ttgaccaatt ggatcacggt tttaccgggg 1618321 cagtaaaatg caatattgat gaaattcctt ttcagcaaat agacagcatc attcttccag 1618381 tatccgcgac aacaggagaa ggtgtcgtat cgactgtatt ttcgaatgaa gaagttgtgt 1618441 taaaacagga ccatcttgac agaacgcctg cacattgtgt cattttctca ggaatttcta 1618501 acgcctattt agaaaacatt gcagctcagg caaaaagaaa acttgttaag ctgtttgagc 1618561 gggatgacat tgcgatatac aactctattc cgacagtaga aggaacgatc atgctggcta 1618621 ttcagcacac ggattatacg atacacggat cacaggtggc cgttctcggt ctggggcgca 1618681 ccgggatgac gattgcccgt acatttgccg cgctcggggc gaatgtaaaa gtgggggcaa 1618741 gaagttcagc gcatctggca cgtatcactg aaatggggct cgttcctttt cataccgatg 1618801 agctgaaaga gcatgtaaaa gatatagata tttgcattaa taccataccg agtatgattt 1618861 taaatcaaac ggtactttct agcatgacac caaaaacctt aatattggat ctggcctcac 1618921 gtcccggggg aacggatttt aaatatgccg agaaacaagg gattaaagca cttcttgctc 1618981 ccgggcttcc agggattgtc gctcctaaaa cagctgggca aatccttgca aacgtcttga 1619041 gcaagctttt ggctgaaata caagctgagg aggggaaata aggatgtcgt cattaaaagg 1619101 aaaaagaatc gggtttgggc tgaccgggtc gcattgcaca tatgaagcgg ttttcccgca 1619161 aattgaggag ttggtcaacg aaggagctga agtccgtccg gttgtcacat ttaatgtaaa 1619221 atctacaaat acccgatttg gagagggcgc agaatgggtt aaaaaaattg aagacctgac 1619281 tggatatgag gccattgatt cgattgtaaa ggcagaacct cttgggccga agctgcccct 1619341 tgactgcatg gtcattgcgc ctttaacagg caattcaatg agcaagctgg caaatgccat 1619401 gacggacagc ccggtgctga tggcggcaaa agcgacaatc cggaacaatc ggcctgtcgt 1619461 tctgggtatc tcgacaaatg atgctcttgg tttaaacgga acaaatttaa tgaggctcat 1619521 gtcaacaaaa aatatctttt ttattccatt cgggcaagat gatccattta aaaaaccgaa 1619581 ttcaatggta gccaaaatgg atctgcttcc gcaaacgatt gaaaaggcac tcatgcacca 1619641 gcagcttcag ccgattctag ttgagaatta tcagggaaat gactaaattt acagaaaatc 1619701 tttcccaaac taaaaaattc ggtcatcacc cgcatattct atggtaaaat aaaacgtaaa 1619761 atcatagtca aatcaattca atgaagctga ttggcggaag gagttttaca gatgggaaga 1619821 ggtttacacg tagctgttgt cggagcgaca ggggctgtgg gacaacaaat gcttaaaaca 1619881 cttgaagaca gaaactttga aatggacaca cttacattgc tatcttcaaa acgctctgcg 1619941 gggacaaaag tcacgtttaa aggccaagag ctgactgttc aggaagcttc tcctgagagc 1620001 tttgaagggg taaatattgc tttgttcagc gccggcggaa gcgtatcaca agcattggca 1620061 ccagaagctg taaaacgcgg cgctattgtt atagataata cgagtgcgtt ccgcatggat 1620121 gaaaatacac cgcttgttgt gccagaagtg aatgaggcag acttgcatga acacaacggc 1620181 attattgcca atccaaactg ctctacaatc caaatggttg cggcacttga accgatccgc 1620241 aaagcatatg gcttaaacaa ggtcatcgta tcaacttacc aggcagtatc aggagcgggt 1620301 aatgaagctg taaaagagct ttacagccaa acacaggcga ttttaaataa agaagaaata 1620361 gagcctgaga tcatgcctgt aaaaggtgac aaaaaacact atcaaatcgc cttcaacgcg 1620421 attccgcaaa tcgataaatt ccaagataac ggctatacgt ttgaggaaat gaaaatgata 1620481 aatgaaacga aaaaaatcat gcacatgcct gaccttcaag tagcggctac atgtgtgaga 1620541 ctgccaatcc aaactgggca ctcagagtcc gtctacatcg aaatagaccg tgatgacgct 1620601 acagttgaag atattaaaaa tctattgaaa gaagctccgg gcgtgacact tcaggatgat 1620661 ccaagccagc agctttatcc gatgcctgct gatgctgtcg gcaaaaacga tgtgtttgta 1620721 ggccgcatcc gcaaagactt ggacagagca aacggttttc atttatgggt tgtttctgat 1620781 aacctattaa aaggcgcggc atggaactct gttcaaattg cagaaagcct gaaaaaacta 1620841 aacctcgtat aaaagagaga attttctaaa gacgaataga agagagtaag gcgctatcag 1620901 cctgctctct tctgttacgt ccgaataatt tggagtgaaa acagtgaaga taattgttca 1620961 aaagttcggc ggaacatcag taaaagatga taaaggccgc aaactggctt tagggcatat 1621021 taaagaagca atcagtgaag gatataaggt tgtcgttgtc gtttcagcga tgggccgaaa 1621081 aggggacccg tatgcaacag attctttgct cgggctgctt tacggcgatc agtcagcgat 1621141 ttctcctagg gagcaggatt tgcttttatc ttgcggagag actatttcct ctgtcgtctt 1621201 tacaagcatg ctgcttgata acggtgtgaa agcagctgcg ctgacagggg ctcaggctgg 1621261 ctttttaacg aatgatcagc atactaatgc gaaaatcatt gaaatgaaac cggagcgttt 1621321 attcagtgtg ctcgccaatc atgatgcggt agtcgtcgca ggcttccagg gcgcaactga 1621381 aaagggtgat acaacaacaa tcggcagagg gggcagcgat acgtctgcag ccgcactcgg 1621441 agcagctgtt gatgcggaat acatcgatat tttcaccgat gtagaaggcg tgatgactgc 1621501 tgacccaaga gtggtagaaa atgcaaaacc gcttcctgtt gtgacgtata cggaaatctg 1621561 caacctggcg tatcaggggg ccaaggtcat ttctccgcgt gctgtggaaa tcgcaatgca 1621621 ggccaaggtt ccgatccgcg tccgttcgac ttattcgaat gataaaggca cattggtgac 1621681 atcacatcac tcttccaagg tcggcagtga tgtttttgaa aggctgatta cgggaatcgc 1621741 ccatgtcaaa gatgtcacgc agttcaaagt gcctgcgaaa atcggccagt ataacgttca 1621801 gactgaagtg ttcaaggcta tggcaaacgc tggaatcagt gtcgatttct ttaacattac 1621861 acctagtgaa atcgtctata cggtagccgg aaataaaaca gaaacagctc agcgtatttt 1621921 aatggatatg ggctatgatc caatggtgac gagaaactgc gcgaaggtat cggcggtcgg 1621981 cgcgggcatt atgggtgttc ccggtgttac gtccaaaatt gtatcggctc tttcagaaaa 1622041 agaaattccg atccttcagt cggctgacag ccatacgacg atatgggtgc tcgtccatga 1622101 agcggatatg gttcctgctg taaacgcttt gcatgaagtg tttgaacttt cgaagtaaat 1622161 gtgattgaat catgatgagg tgaataaaat gaatttcgga aatgtgtcta cagcgatgat 1622221 tacacccttt gacaataaag ggaacgtaga ctttcaaaaa ctgtctacac tgattgatta 1622281 cttgttgaaa aacggaacgg attctttagt agtagcggga acaactggag aatctccgac 1622341 cctttcaact gaagaaaaaa ttgcgctttt tgaatatacg gtaaaagaag taaacggacg 1622401 ggtgcccgtt atcgctggta ctgggagcaa caacacgaaa gattccatta agctgacaaa 1622461 aaaagctgag gaagcgggcg tggacgctgt tatgcttgtt accccgtatt acaataaacc 1622521 ttctcaagaa ggaatgtacc agcattttaa agcaattgcg gcagagacat ctcttccggt 1622581 tatgctctat aatgttcctg gccgtacggt tgcttctctt gctcctgaaa cgacgatccg 1622641 tttggcggca gacattccga atgtggttgc gattaaagaa gcgagcggag acctcgaagc 1622701 gattacaaaa attattgctg aaacacctga agacttctat gtctattcag gggatgatgc 1622761 tctaacgctt ccaattcttt cagttggagg tagaggagtt gtgtcagtgg cgagccatat 1622821 tgcaggcact gatatgcagc aaatgatcaa aaattatacg aatgggcaaa cagctaatgc 1622881 ggcactgatt catcagaaac tgctgccgat tatgaaggaa ctgtttaaag cgcctaatcc 1622941 tgctccagtc aaaacagcgc ttcagctgag aggtcttgat gtcggttctg tgcgtctgcc 1623001 tctagtccca ttaactgagg atgaacgtct gagcttaagc agcacgatca gcgaactgta 1623061 agaaaatttc atacagtgaa acaaacgcgg tcattctcac attcagctga gtttgaccgt 1623121 ttcttttaca tattggtttt ccctaaacct tctgctttat cttgttttct aaatttactt 1623181 tcagttataa taggaacaag tgatgatgga cgggtatgag actaggagga tatagatttt 1623241 gaaaaagaaa aatacagaaa acgttagaat tatcgccctt ggcggtgtcg gagagattgg 1623301 gaagaacctt tatgtcattg aaattgactc agacatattt gtcgttgatg ccggccttat 1623361 gcatccagaa aacgaaatgc tcggtattga tgtagtgatt cctgacatat catatttgat 1623421 tgaacgggct gaccgcgtca aggcaatctt tttaacgcac gggcacgatg aaaatatcgg 1623481 cggcgttttt tacttattaa acaagctgtc cgttccagtg tacggaacaa aactgacgct 1623541 tgcactgtta agagagaaat taaaacaata cggacataac cgaaaaactg atttaagaga 1623601 aattcactcc aaatctgtca ttacatttga atcaacaaag gtatcgttct ttagaacgat 1623661 tcacagcatt cctgattctg taggtgtgag ctttaaaaca tcacttggat ctattgtatg 1623721 cacgggagac ttcaaatttg accaaacacc tgcacttaat cagacgtgcg acattggcga 1623781 gatcgccaag atcggcaata gcggcgtgct cgctctgctt tctgacagtg caaatgcgga 1623841 acggccgggt tacacccctt cggaagcggc tgtcagcgga gaaatttcgg atgcgctgta 1623901 taattcacag aaccgggtga ttattgctgt tttcgcatcc aatattaacc ggattcagca 1623961 agtcattcat gcagcggctc aaaatggcag aaagattgcc gtagccggaa aaaatcttca 1624021 atctgtcctg cagctggcga gaaagttagg atatattgaa gcagatgatg aattgtttat 1624081 ttctgtacag gatgtcaaaa aatatccgaa gcgcgaagtg gccattatta cagccggaag 1624141 ccaaggtgaa ccattagctg ctttgacaag aatggcaaac aaagctcaca aacagctgaa 1624201 cattgaagaa ggggatacgg tggtcattgc gtcaactccg attcccgggc aggaactcat 1624261 ttactctaaa acagtagatc ttcttgcgag agccggtgca caagtcatct ttgcccaaaa 1624321 gcgtgttcat gtatcaggcc acggctcaca agaagagtta aagctgatga tcaacctgct 1624381 taaaccaaaa tatttgattc ctgtaaacgg cgaatacaga atgcaaaaag ctcattcaaa 1624441 aatcgctgaa gaaaccggca tgaagcgcag tgacatcttc ttaattgaaa aaggcgacgt 1624501 cgttgaattc cgcggccaaa acgtaaaaat tggggataaa gttccttacg gcaatatttt 1624561 aattgatggt ttaggtgtcg gtgatatcgg caatatcgta ttgagagacc gccgcttgct 1624621 ttcacaggac ggaattttaa tcgttgtcat tacacttgat aaacaaaaga aacatcttgt 1624681 atcaggacca gaaattatca ctcgcggctt tgtttatgta agagagtctg aaggtcttat 1624741 cgtacaggct actgagcttg tacggtccat cgtgacagaa gcgactgaaa catcaaatgt 1624801 cgaatggtca acgctgaagc aggcaatgcg ggatgctttg aaccaattcc tttatgaaaa 1624861 aacgaaacgt aaaccgatga tcatcccaat tattatggaa gtataatgac tgactaaaga 1624921 ccggagctgc tccggtcttt attttttgtc cttcaagccg ggattgaatg aagtatcttt 1624981 gttcataata caaagagaaa ctcggaaagg atgaaagcga gatggatcat cgtatggaaa 1625041 acacagaaga agagcgtcct gaaaaaaatg atgcgaagga cagcattatg aataaaatac 1625101 agcagcttgg tgaaacgacg cttccgcagc tgccccaaga tacaaatatt cattgtctga 1625161 ccattatcgg acaaattgaa ggccatgttc agcttcctcc gcaaaacaaa acaacaaaat 1625221 atgaacatgt catcccgcag attgtggcaa ttgaacaaaa tcccaaaatt gaaggcttgc 1625281 tgatcatatt aaatactgtc ggaggagatg ttgaagctgg tcttgccata gcggaaatgc 1625341 ttgcatcttt atcgaaaccg accgtttcta tcgtgcttgg cggggggcat tcaatcggcg 1625401 ttccgattgc tgtatcctgt gattacagct atatcgccga aacagcaacg atgacgattc 1625461 atccagttag gctcaccggg ctggtcatcg gggtgccgca aacgtttgaa tacctggata 1625521 agatgcaaga aagagttgtt aaatttgtga caagccattc caatataacc gaagagaagt 1625581 ttaaagagct aatgttttca aaaggaaact taacacgcga tatcggaaca aatgtagtcg 1625641 gtaaggatgc agttaaatac ggattgatcg atcacgcagg cggtgtcgga caggcaatca 1625701 ataaactgaa tgagctcatc gatgaagcaa ggaaagaaga aggacggatg attcaatgat 1625761 tctttatacc gtgatgcctc aggaaattgt gtttgcagaa cagaaccaag agacaagcgc 1625821 acatgagcaa attgaatata aaggtgtacc gcttctagtc gaaatgaaag ggaatgaagc 1625881 ggaagtcatt caaatcatga gcaccaatcc aatgcatttt ctgcatccgg acatttcacc 1625941 gggacaaaag ctgaaattaa acgtataaga atccaaccct tttttaaggg caaaatatgc 1626001 tataataggg gaatcctaca gaaaaaacgc agcctgtaaa cggctgcttt cttcattatg 1626061 tatgaactta cattttttaa cgcagtaagg tgatgagtgt ggcaaagaaa aaacgaaaat 1626121 caagaaaaaa acaggcgaaa cagctcaata taaaatacga gctcaacgga ttgctgtgta 1626181 tagccatttc aattatcgca atcttgcagc tgggggtagt cgggcaaacg tttatctatt 1626241 tgttccgctt ttttgctgga gagtggttta ttttatgctt gttaggttta ttggtgttag 1626301 gagtctcact gttttggaag aaaaaaaccc caagcctttt aacgagacga aaggccgggt 1626361 tgtactgtat tatcgcaagc atattgctgc tttctcacgt gcagctattt aaaaatttga 1626421 cgcacaaagg gtctattgag tctgcaagcg tggtgcgcaa tacgtgggaa ttgtttttaa 1626481 tggacatgaa tggcagctct gcttcacctg atttaggcgg agggatgatc ggtgcgctgc 1626541 tgtttgcggc ttcacacttt ttgtttgcgt cgactggttc tcagatcatg gcaattgtca 1626601 tgattttgat cggaatgatt ttagtaacag gacgctcgct gcaagaaacg ctaaaaaagt 1626661 ggatgagccc gattggacgt tttataaaag aacaatggtt agcatttatt gatgacatga 1626721 aatccttcaa atcaaatatg cagtcatcga aaaaaacgaa agcgccgagc aaaaaacaaa 1626781 aaccggcccg caaaaaacag caaatggaac cggagcctcc tgatgaagag ggggattatg 1626841 aaacagtatc gcctcttatt cattcagagc cgattatctc aagcttttct gatcgtaatg 1626901 aagaggaaga gtctccagtt atagaaaagc gcgccgaacc tgtgtcgaag ccgcttcagg 1626961 acatccaacc ggagacaggt gatcaggaaa ctgtttctgc tcctcctatg acctttacag 1627021 agctcgaaaa taaggattac gagatgccgt cactggattt gctggcagat ccgaagcata 1627081 ccggccagca ggctgataaa aagaatattt atgaaaatgc gagaaagctt gaacgcacat 1627141 tccaaagctt tggcgtaaag gcgaaagtca cacaggttca tctcggaccg gccgtaacaa 1627201 aatatgaagt atatcctgat gtcggagtga aggttagcaa aattgtcaat ttaagcgatg 1627261 atttagcgct tgcgcttgct gcgaaggata tcaggatcga agcgcctata ccaggcaaat 1627321 cagcaatcgg aattgaagtt ccaaacgcag aagtggcaat ggtttcgctg aaagaagtgc 1627381 tggagtctaa attgaatgac agaccggatg cgaagctgtt aattggactc ggccgcaata 1627441 tttcaggtga agctgtattg gctgagttaa acaagatgcc ccaccttttg gtcgcaggcg 1627501 caaccggtag cgggaaaagt gtctgtgtca acggcattat tacaagtatt ttaatgcggg 1627561 cgaaaccgca tgaagtgaaa atgatgatga tcgatcctaa aatggtagag ctaaatgtct 1627621 acaacgggat tccgcatttg cttgctcctg ttgtaaccga tccgaaaaaa gcgtcgcagg 1627681 ctttgaaaaa ggttgtcaat gaaatggagc ggcggtacga attattttct catacgggta 1627741 caagaaatat tgaaggatac aatgattata taaaacgcgc caacaatgaa gaaggagcga 1627801 aacagccaga gctgccttat attgttgtca ttgtggacga gctagccgat ctcatgatgg 1627861 tcgcttcatc tgatgtggaa gattcgatta cgagattgtc ccaaatggcg cgggctgccg 1627921 gcatccatct tattattgcg acacagcggc catcggtgga tgttatcaca ggggtgatca 1627981 aagcgaacat tccgtcacga atcgcgttca gcgtatcttc acagacggat tcaaggacca 1628041 ttcttgacat gggtggcgct gagaagcttc ttggccgcgg cgatatgctg tttttacctg 1628101 taggggctaa caaacctgtc cgtgtgcagg gagcattttt gtcggatgac gaagtggaga 1628161 aggtcgtcga ccatgtgatt actcagcaga aagcgcaata tcaagaagaa atgattcctg 1628221 aggagacgac ggaaactcat tccgaggtta ctgatgaact ttatgatgaa gctgttgaat 1628281 taatcgtcgg catgcagacg gcatctgttt caatgctgca aagaagattc agaattggct 1628341 atacgagagc ggcgcgcctg attgacgcaa tggaggaacg cggtgttgtc ggaccgtatg 1628401 aaggcagcaa acctagggaa gtattattat caaaagagaa atatgatgag ctctcttctt 1628461 aatgaaggga gttccgcttt ctatagttgt caataatgat attatgtaaa ctgatcacct 1628521 ttctatttat tttttcgaca aaacatgata tagttgtccc aattgttcaa taatttttat 1628581 cgaaagtggt ttacggaggg gaaacatgtc tacaaaagct gataatcggc acttgtattt 1628641 gaaagtaatt gaacgaatta aagaggatat aaaaaatggg atctacactg agaaggaaaa 1628701 gctgccttct gaatttgagc tttccaaaaa gcttggtgtc agcagagcga cgctaagaga 1628761 agccttgcgg atactggaag aagagcatgt gattatcaga aggcatggtg taggcacttt 1628821 tgtccattct aagccgttat ttctttcggg tattgaacag ctgaacagtg taaccaagat 1628881 gatagaacag gcgaatatga cccctggcac gatttttcta tcatcacaag tgcttatgcc 1628941 gtctgaagat gatacgaaga gatttcactt ggcagaaggg caagaacttt tttaccttga 1629001 acgagtcagg acagctgacg gacagccgat tgtgtattgt atagacaaaa ttccgatgaa 1629061 tattttgccg aattcttttt ctcatcagca agaatctatg tttgacctgc tagagaaaaa 1629121 ttcaggctcc gtaatcagct atgcagtaac tgatatagaa ccgatcggct atcacgatac 1629181 catttctcca gtgcttgaat gcgatccgga aacagctctt ttgctgttaa aacaaaccca 1629241 ttacgatcag cacgataaac cggtgcttta ttctttaaat tattttagag cggataaatt 1629301 cagatttcat gttttgcgta aacgattcta aaaacggacg cctgtatgtg tctgtttttt 1629361 tatttgcact gattcatgtt tctttgtaca tactttcatt ccggttaacg caatatataa 1629421 gggatgacaa gaaagtgaat gggtgaaaat gttgagagag aaaaatggaa tgaaaaatat 1629481 tattgcattg tcttctgtcc cgcttgtgat gacactcggg aactccatgc tgattcctgt 1629541 tcttccgatg atggagaaaa agctgtctgt gacttcattt caagtatctt taatcattac 1629601 tgtatattca gtagtagcaa ttatttgcat tccgattgcc ggatatttgt cggatcgttt 1629661 cgggagaaaa aaaatattgc ttccatgcct cctcattgca ggattggggg gagccgtagc 1629721 tgcttttgcc tcgacctata tgaaaaatcc ttatgctatg atcttggcgg ggcgggttct 1629781 tcaaggcatt ggttctgcag gtgccgctcc gattgtcatg ccgtttatcg gcgacctgtt 1629841 taaaggagac gatgaaaagg tcagcgcggg tcttggcgat attgaaaccg ccaacacgtc 1629901 agggaaggta ctgagtccca tacttggagc cttactggct tcttggtatt ggtttgtacc 1629961 gttttggttt attccgtttt tctgtttgat cagctttttg ctcgtattgt ttttggtggc 1630021 caagcctgaa gaagatgaag atgcgcctgc tgtttctgag tttattaaga gtgtgaagaa 1630081 aatttttaaa caggatggtc gctggcttta tacggtcttc attatcgggt gtgtcattat 1630141 gtttttgtta tttggcgtat tattttattt atcagatacg ctggagaaca agtatgctat 1630201 tgacggagta gctaaaggcg gattactggc aatcccactt ttgtttttgt caaccagttc 1630261 ttttatagct ggcaaaaaga tcggtaaaga taaaggccga atgaaatttt gcgttgttac 1630321 aggaatgatt ctgttaaccc tttcgtttat tgccttgtgg tggaaccaca gtttttattt 1630381 tttatttgtc tttttaagct ttggcgggat tgggattgga atggctcttc ctgctttaga 1630441 tgcattgata accgaaggga ttgaaagtga acaatgcgga accatttcct ccttttacaa 1630501 tagcatgcgc tttataggag tagctctcgg tccacctgtt tttgctgcat taatgtctaa 1630561 tgcaaactgg attattttca tactctcggc gttttgcagc atcgtttctt tatttttagt 1630621 gctctttact gtagatgcta aaaaaagtga agaagaaaaa aacttaggga cggtctagcc 1630681 agccgtcttt ttttgcgctt tcttgcacag tttacaactg tacctataca gcatgcggag 1630741 gttattgttt ccttataaat cctacagttg ctataattac atgaaagagt gtttctgcgg 1630801 atgctgaaaa ttggtcataa tacatactaa ttaagaaatg aacgaaggag gttccatatg 1630861 tcatatgtta atgaactcaa atcaaagcac ggcggtttaa ccgcacacat tgtaaaaaca 1630921 gaaaaattca aaaccgtctc gcttattttt aagatgcttg cgccgctgac aaaggatcaa 1630981 gtcaccaaaa gagcgcttct cccgcatgtg cttcttcgcg gaacgaaaag ccatccgaaa 1631041 accgcaggat tgcgttcata cttggatgag ctgtacggca cgtcagtatc ggctgatctt 1631101 acgaaaaaag gagagcggca tgtcattacg ttcaggcttg aaatcccgaa tgaaaaatat 1631161 ttaaaagacc aaacgccgct tctcgagaaa gggctccagc ttctcgcaga actcgtcttt 1631221 tcacctgctt tggagggaga cgcttttcag tcacaatatg tggctcaaga aaaacggacg 1631281 cttaagcaaa gaatccaagc cgtctatgat gataaaatgc gttattcgaa tttaaggctg 1631341 atacaggaaa tgtgcaaaaa tgatccttac gcgcttcatg tcaatggtga aatcgacgat 1631401 gtcgatgaca ttacggcaga gcaattatac gaaacatacc aaagcgctat ccaaaaagac 1631461 cagcttgatc tatatgttgt tggcgacgtg gacagtaacc aggtacaatc ggcaattgat 1631521 aagtatttca aaacagaaga gcgcactctt ggcatgattg aaaacaatca cgctgatgaa 1631581 aaagttcagc caaaagaagt aattgatgaa gaggatgtca agcaaggaaa actgaatatc 1631641 ggctaccgca ccagcatcac ttatacagat caggattatc ctgctttaca agtgtttaac 1631701 ggattgttcg gcggattctc tcattctaaa cttttcatta atgttcggga aaaagccagt 1631761 cttgcttact acgcggcttc gcgtatagaa agttttaaag gcttgttaat ggtgatgtca 1631821 ggcattgaag tgaaaaattt tgaacaggcg gtttcgatta ttgctgagca attccaggca 1631881 atgaaaaatg gcgatttcag tgagcaggat atagcacaga caaaggccgt tattcgaaat 1631941 caagtgctgg aaacgattga tacagcatac ggtttatctg agtttttata tcagcaggcc 1632001 gctgctcaag tcgagattcc tatcgaagac tttcttgcca atattgagaa tgtcacaaaa 1632061 gaggatatca ttaaagccgg cgaaaagatt cagcttgata cgacttattt cttaaaaggg 1632121 acggagggtg catcttgatc aaaccaatcg aatatgaaca gcttcaggag acgctgtatc 1632181 atgaaaaaat gtccaacggc cttgatgttt acgttttgcc gaaaaaaggc ttcaacaaga 1632241 catatgcggt ctttacaaca aagtacggct cgatagataa ccggtttgtc cctttaggta 1632301 aaaacgagat ggttcacgtg ccggacggga ttgctcactt tcttgagcac aagctgtttg 1632361 agaaagcgga cggagacgtt tttcaagatt tcagcaaaca gggggcttct gccaatgcgt 1632421 ttacgtcatt tacaagaacg gcttaccttt tctcaagcac atcaaatgtt gaacgcaatt 1632481 tagagacgct tatcgatttc gtacaggacc catattttac tgaaaaaacg gttgaaaagg 1632541 aaaaagggat tatcgggcag gagattaata tgtacgacga taaccctgat tggaggcttt 1632601 acttcggggt cattgaaaac atgtacaaag agcatcctgt cagaattgac atagcgggaa 1632661 cagtggaaag catttcacat attacaaaag accttcttta tgaatgctat gaaacgtttt 1632721 atcacccgag taacatgctc cttttcattg tcggccctgt agatcctgaa gcgattattt 1632781 ctcaggtaag agaaaaccag gggaaaaagc cgtatactga tcagccggag atcaaacgag 1632841 aagaagtgaa agagcaagaa gcggttttcc gaaaagaaaa agagatcaaa atgaacgtgc 1632901 agggaccgaa atgccttgtt gggctgaaat ccaaaaatcc gtttaaatta ggcaaagagc 1632961 tcttaaagca tgaactttca atgaacttat tgcttgaagc tctttttggc aaaagctctg 1633021 cccagtatga atcactttat gaaaaaggat atattgacga aacgttcagc tttgatttta 1633081 ctgctgaata tgggttcggt tttgcggcga tcggcggaga tacgcctgag cctgatcaat 1633141 tggctgaaga catttcaagc atgcttttgc gcgccggtga actgattact gctgaaaaga 1633201 ttgaacttgc cagaaagaaa aagatcggca cattcttaaa agcgctgaat tcccctgaat 1633261 acatcgccaa tcaatttacc cgttatgcgt tcttggatat gagcctgttt gatgttgtaa 1633321 cggtactcga gcagattacc ctcgaggatg tccagaacgt aatacaagag gaaatcgctg 1633381 cagacagact gactgtctgc aaggttgttc ctaaatcata aacaaaacat ccctccagtg 1633441 tgaggggtgt ttttctgcgg aaagaaggaa agaggatgaa caaaacagca ctaatcaccg 1633501 gagcaagcgg cggcattggc aaaagcatca gcgaaaccct tgcagctaga ggatacaatc 1633561 tgctgctgca ttacaataca aatcaaaacg cggcagcgga gcttgctgaa aaactaagtc 1633621 agatgtttgg cgtaaatgcg gagatattac aagctgacct gtccgcgcaa gatggagcag 1633681 ataagctgac aagttcaatt gttcagccga ttgatgcgat tgttttaaac agcggacgaa 1633741 gccattttgg gctgattacg gatgtagata acgcaacggt ccaggaaatg gttcagcttc 1633801 atgtggcgag tccgtatatg ctgacgagaa accttctgcc aggcatgatt cggaataaat 1633861 cgggagcgat tgtggctgtc agctcgattt ggggagagac tggagcatcc tgtgaagtgt 1633921 tgtacagcat ggcaaaagga gctcagcatt catttgtaaa aggattggct aaggagctgg 1633981 cgccaagcgg aatcagagta aacgccgtag cgccgggtgc agttgataca aatatgatga 1634041 atcaatttac cccggctgaa aaagaagaga tcgctgatga gattccgatc ggccggctgg 1634101 cccggccgca agaaattgcg gatgcaacag cttttctcct gtctgaaaaa gcgtcatata 1634161 tcaccggcca aattctgtcg gtgaatggcg gctggcactg ctgatccgaa aatattcggt 1634221 gtatagtttc ttttgcgaag gacacaataa tcttgtaact tcacatgaaa tggaggaaac 1634281 aagcatgtca gtattagaaa actgggatag ctggaaaaac ttccttggcg accgtctgaa 1634341 ctatgcgcaa gataaaggta tgagccagga tacgattaca gatcttgcga cagaaatcgg 1634401 cagctacttg gctaatgaag tggaatctaa gaacgagcag gaaaaagtgc tggcagatct 1634461 ttggagtgta gcatcaaaag atgaacagca cgccattgcc aatatgatgg ttaagcttgt 1634521 tgaaaataac agcactcact aggaagagag gggatttttc ctctcttttt tatgttttcc 1634581 tcatcacagc aacattcttc tttctaatta gagaaaaatg ctttatgata aaggaaggta 1634641 aaattttgcc acaatgaagg gggtatatca tttggcaaag ctcgaatggt attttgaata 1634701 tgaaattcaa gtgaaccgcc ccggactgct cggggatatt tcatctcttc ttgggatgct 1634761 ttctatcaac atcgtaacga taaacggcgt cgatctttcc agaaggggaa tgctcctcag 1634821 gtgccgccat atagatcaaa ttaaacgatt agaatcaatc ttaaaaacga tggaaacaat 1634881 taaagtaacg aagcttagag aaccgaggct tcgcgaccgt cttgccgtac gccacggccg 1634941 ttatattcaa cgggatgccg atgacaagaa aacgttccgc tttgaacggg acgagcttgg 1635001 cttattagtc gattttatgg ccgaattgtt caaaaaagaa ggccataaat taatcggaat 1635061 cagaggtatg ccgcgtgtcg ggaaaacgga atcgattgta gcctctagtg tgtgcgagca 1635121 aaaggtggct gtttgtgtca tcaaccttgc tgaagcagac gataagaagc cagctgattg 1635181 ccgatgaata cagcactgaa aatgtcttta tcgttgacgg aattgtgtca acacgaagag 1635241 ggtcagaacg ccatctccag ctggtccgag aaatcatgcg gctgcctgca acaaaagtgg 1635301 tggagcatcc ggacatattc gttcaaaata cagagtatac actagatgac tttgattata 1635361 ttattgaact gagaaatgac cctgatgagg ttattacata tgaacatgcc gaggaacccc 1635421 aaatgtttga tcaatccggg ttttcaagct ttgattttta aaattggaag gtgtttgttg 1635481 tgactgaact aggaatccgg ctcaaagaag ccagagagga aaaagcaatg tcattggatg 1635541 atctccaagc ggcaacaaag attcaaaaaa ggtatttaac cgccttggag gaaggaaact 1635601 atgacattat tccggggaag ttttatgttc gggcattcat caagcaatat gcagaagccg 1635661 ttgggcttga tgcggatcag ctgtttgagg agcataaaaa agatatccct aatacgtatc 1635721 atgatgatgt gtctgaaaag atctccggca tgaatcttca aaaggaaatg ccaaagccag 1635781 catctaaggc gctggagctg ctgccaacaa tacttgttat tctcggcgtg attgtcgtga 1635841 ttgccattgt gtacgcgatc attcaatttg ccaatcacaa aaacagtgat gatcacaatg 1635901 cggcatcaga aaaagcaatt acgcaaagtg agagcaagta cgaaatccct aaagattcaa 1635961 cgctgaaaga gaatcaaaat aacagctctg aaaaagagac agacactaaa aaagaaacga 1636021 aagaaaacga agataagaaa aaagaaaatg acagtgagaa gctggagatt aaagctgctg 1636081 gcactgaagg atcgttaacg acttatgaag tgtccggcgc tgataaaatc gagctggaac 1636141 tgaaggcatc agacagctcc tggattagag tgcgcgatga aaacagcagc tctttaaaag 1636201 aaggaacgct gaaaaaagac gaaacctata aaaaagacat aactgatcag aaacaagttg 1636261 atatccgcac cggatatgca cctaatctga aaataaaaat caacggtaag gttctttcat 1636321 atgaacttga tccgaaaaaa gtgatggcac aaaccataaa gattgtaaat aaaaaggaag 1636381 aaaagtcatc ttaattacca gatgactttt cttcacgtcc gagtatgaaa ttggaggggc 1636441 tttatgttta acttaccaaa taaaatcaca ctagctagaa tcgcattaat cccaatcttc 1636501 atgattatca tgctggcgcc gtttgactgg ggcaggctcg aagttggaga cgaatccatc 1636561 ccggtcgcac atttggcggg ggccattcta tttattattg catctacaac agactgggtg 1636621 gacgggtatt atgcccgaaa attaaatctc gtaacaaact tcgggaaatt tcttgatccg 1636681 cttgcggaca aactgctcgt atccgcagcg ttaattatcc ttgttcaatt tgatctcgct 1636741 ccagcttgga tggtcattgt gattatcagc agggagtttg ccgtgacagg tttaaggctt 1636801 gtcttagccg gaacaggaga agtcgtagct gctaacatgc ttggtaaaat caaaacctgg 1636861 gcacagatta ttgcggtatc tgcattgctt cttcataatc ttccatttga acttgtgtca 1636921 ttcccgtttg cagacttggc gctgtgggta gccgtcttct ttactgtcgt ctcaggctgg 1636981 gaatatttct ctaaaaattg ggaagcgtta aaaacatcta actaagaaag aaggacttcg 1637041 tcatggaatt tccaaaaaaa gcagaaataa ttgcagtcgg ttcagagttg ctgcttggtc 1637101 aaatcgccaa tacaaatgct caatttatca gcaaacagct cgctgaaatc ggggtcaacg 1637161 tattttatca tacagcggtc ggagataacc cggagcggct gaagcaggtc atccgcattg 1637221 ctgaagaacg ctctgacttc attatttttt caggagggct tggacccaca aaagatgatc 1637281 tgacgaaaga aacgattgca aatacgctgg gacgtccgct tgtgttaaat gatgaggcat 1637341 tccaatccat tgaggactat ttcaaacgaa caaaacgcac gatgtcacct aataaccgaa 1637401 aacaggcgct tgtgatcgaa ggctctgacg tgctggcgaa tcactttgga atggccccgg 1637461 gaatgctcac agagcatgaa tcgcgctatt atatgcttct tcctggaccg ccgagcgaat 1637521 tgcgtccaat gtttgaaaac gaggcaaagc ctcttctgct gaaaaagatg ggttcaaatg 1637581 aaaaaattgt gtcaactgtt cttcgctttt tcggtatcgg tgaatctcag cttgaagccg 1637641 atttggaaga tattattgat gcacaaacca atccgacaat tgcgcctttg gcggctgatg 1637701 gagaggtgac gctgcgtctg acagccaaac acgccgatga aaaggaaaca gagcgtctgt 1637761 taaaagaaac agaggccgtt atcttagagc gtgtcggtga atttttctat ggttacgatg 1637821 atacttctct tgtaaaagag ctatctatag catgtaagga aaaaggcata acaatttctg 1637881 cggcagaaag ctttaccgga gggctgtttt ctgaatggct gacggatcat agcggtgcct 1637941 caaaattatt tgccgggggc gttgtttgct atacaaacga cgtgaagcag aatgtgcttg 1638001 gtgtcaagaa ggaaacatta gatcgttttg gggcggtcag caaggagtgc gcatccgaac 1638061 tggctaaggg tgttcaaaaa ctcactggca gcgatatcgg cattagcttt actggtgtag 1638121 caggacctga tgctcaagaa gggcatgagc ctgggcatgt gtttatcggc atttccgcaa 1638181 atggtaaaga agaggttcac gagtttcact ttgcgggctc cagaacgggg atcagaaaac 1638241 gcggcgctaa atacggctgc catttaatct taaagctttt agagcaaaaa taatattttc 1638301 agcacattat cctcctaaga aaacatgatt tctctgatac attatgatat tttgatagga 1638361 atcacgccaa gaaaaaatcc gaatatgcgt tcgctttttt cttggcaaat cccttcaaac 1638421 agggtatagt atatgtagtg gtaacataaa ggaggaaaaa atagaatgag tgatcgtcag 1638481 gcagccttag atatggctct taaacaaata gaaaaacagt tcggcaaagg ttccattatg 1638541 aaactgggag aaaagacaga tacaagaatt tctactgtac caagcggctc cctcgctctt 1638601 gatacagcac tgggaattgg cggatatcct cgcggacgga ttattgaagt atacggtcct 1638661 gaaagctcag gtaaaacaac tgtggcgctt catgcgattg ctgaagttca gcagcagggc 1638721 ggacaagccg cgtttatcga tgcggagcat gcgttagatc cggtatacgc gcaaaagctc 1638781 ggtgttaaca tcgaagagct tttactgtct cagcctgaca caggcgagca ggcgcttgaa 1638841 attgcggaag cattggttcg aagcggggca gttgacattg tcgttgtcga ctctgtagcc 1638901 gctctcgttc cgaaagcgga aattgaaggc gacatgggag attcgcatgt cggtttacaa 1638961 gcacgcttaa tgtctcaagc gcttcgtaag ctttcagggg ccattaacaa atcgaagaca 1639021 atcgcgattt tcattaacca aattcgtgaa aaagtcggtg ttatgttcgg gaacccggaa 1639081 acaacacctg gcggccgtgc gttgaaattc tattcttccg tgcgtcttga agtgcgccgt 1639141 gctgaacagc tgaaacaagg caacgacgta atggggaaca aaacgaaaat caaagtcgtg 1639201 aaaaacaagg tggctccgcc gttccgtaca gccgaggttg acattatgta cggagaaggc 1639261 atttcaaaag aaggcgaaat cattgatcta ggaactgaac ttgatatcgt gcaaaaaagc 1639321 ggttcatggt actcttatga agaagagcgt cttggccaag gccgtgaaaa tgcaaaacaa 1639381 ttcctgaaag aaaataaaga tatcatgctg atgatccagg agcaaattcg cgaacattac 1639441 ggcttggata ataacggagt agtgcagcag caagctgaag agacacaaga agaactcgaa 1639501 tttgaagaat aaaaataaaa taagtttcaa atgatacaaa aggctgagtg aaaaactcag 1639561 cttttttgta ttttgcaaaa aaatgataaa aatattgctt tttttgacaa cttttttagg 1639621 gctttattcg tctaacaaaa cgtgtgcaaa atggaattta ttttgggagg aaaaaatgaa 1639681 tgacaagccc aacccgcaga agaactgcga aacgcagacg gagaaaacta aataaaagag 1639741 gaaaactgtt gtttggtctt ttagcagtga tggtttgcat tacgatttgg aatgctcttc 1639801 atcgaaatag tgaagaaaac gaaccatctc aagaaactgc agcggtttca aataccgatc 1639861 agaaaaaaga ggtcaaaaag aaaactgcca aaaaatcaga ggaacaaatc aaaacagtgg 1639921 atcgaaacca aaaaatcagc aattatttaa aagagatcgg tttcagcgga acagccatga 1639981 ttgtcagaaa tggagaaatc gtaacaaata aaggttttgg ctatgctgac cgtaaacact 1640041 acattcaaaa taatccattg acatcttttt atgtcggttc atcacaaaaa gcgctgattg 1640101 caactgctat tttgcagctt gaggaaaagg ggaaacttca gacaagtgat ccggtaagca 1640161 cgtatttacc tcattttccc aacggacaaa cgattacttt gaagaatctg cttacacata 1640221 catcggggat aaacggacat attgaaggaa acggcgccat tactccggac gatttaataa 1640281 aagatataga acttcaggga atcaaacgtc agccgggcgt atgggactac aaggattcca 1640341 actattctgt tcttgcttat attattgctg aagtaagcgg tgagccctat gaacagtaca 1640401 taaagaatca tatttttaaa cctgcgggaa tgacgcatgc aggcttttac aaaacatatg 1640461 aaaaagaacc ttatcctgcc gtcgggtata agatggaggg cagcaaaaca gttacaccgt 1640521 atatacctga tttatcccag ctgtatggag cgggtgatat ttatatgagc gctatagata 1640581 tgtacaaatt tgaccaagcg ctgatagacg gaaaactgta ttcgcaaaaa agctatgaaa 1640641 agatgtttac gccagggagc agctccacat acggcatggg attttatgtt gctcccggaa 1640701 gctattcaaa ccatggtgtt atgccgggct tcaatatctt gaacagcttt agcaaatctg 1640761 ggcaaaccat tgttattttg ttctcaaaca ttcaaaataa tgctaaattg ggccaagtga 1640821 acaataaaat ataccagctt ctaaatcaag aatgattggc gatcttcttt tggatgaatt 1640881 gcattcggca cgtgaaaaga agactggcct gcaaacgtta agatggcaag cttgacaagt 1640941 atttccgaca catttacaat gaagttgtaa catttgtttt tttaacatga ttgttaaacc 1641001 atttaaactt gacaagggcg atgaacacac tcattccctg tgaaggttct gtatgttgag 1641061 aaaactagac aatgtacatg ccgacacttt ttaagcaaca accaagttca tagcaagagg 1641121 aggtgaaagt atgaccccaa ttatgatggt tctcatctcc attttgctga ttctactcgg 1641181 tttagttgtt ggctactttg ttcgtaaaac cattgccgaa gcgaaaattg cgggcgcacg 1641241 cggtgcagcc gagcaaattc ttgaagatgc gaagcgtgat gctgaagcac tgaaaaaaga 1641301 agctctgctt gaagcaaagg atgaaatcca caaacttcga atagatgctg aacaggaagt 1641361 tcgtgaaaga cgaaatgagc ttcaaaaaca agaaaaccgt ttactccaaa aggaggaaaa 1641421 ccttgatcgc aaacatgagg gaattgataa acgggaagcg atgttggaga agaaagatca 1641481 ttctctgaat gaacgacaac aacatattga agagatggaa agcaaagtgg atgagatgat 1641541 tcgtatgcag cagtctgagt tggaacgaat ttcgagtctg actcgtgacg aagcgaaaca 1641601 aatcattctt gagcgggttg aaaacgagct ttcacatgac atcgccatca tgacaaaaga 1641661 aactgaaaac cgtgcgaaag aagaggcgga taagaaagcg aaaaacattc tttcactcgc 1641721 cttacagcgc tgcgcagcgg accacgttgc cgaaacaacg gtatcagttg tcaatcttcc 1641781 aaatgatgag atgaaaggac gtatcatcgg acgggaaggg cgtaacattc gtacgcttga 1641841 aacgctgaca ggaattgacc tgattattga tgatacgcct gaagctgtca ttctttccgg 1641901 atttgatccg atcagacgtg agacagccag aattgctctt gataaactcg ttcaggatgg 1641961 ccgtattcat ccggcacgga ttgaagaaat ggttgaaaaa tctcgccgcg aggtcgatga 1642021 ctatattcgt gagatgggtg agcaaacgac atttgaggtt ggcgttcatg gcctccaccc 1642081 agatctcatc aagatcctcg gccgcttaaa gttccgtaca agctacggtc aaaatgtgct 1642141 taagcattcc atggaagtcg cattcttggc cggtctaatg gcatcggagc ttggtgaaga 1642201 cgcaaagctt gctaaacgtg cgggtcttct tcacgacatc gggaaagcaa ttgaccatga 1642261 agtagaagga agccacgttg agatcggggt agagcttgcg accaaatata aagagcaccc 1642321 agtcgtgatt aacagtattg catcacacca cggggacgag gagccgactt ccattattgc 1642381 tgtactggta gctgcagcag atgcgctttc cgctgcaaga cctggcgcaa gaagtgagac 1642441 gctcgagaat tatattcgaa gacttgaaaa acttgaagaa atttctgagt cctacgaagg 1642501 tgttgaaaaa tcatttgcca ttcaggctgg acgcgaagtg cgaattatgg tgaagccgga 1642561 ttcaattaat gatcttgagg ctcatcgact ggcgcgagat atccgcaagc gaattgagga 1642621 cgagctcgat tatccaggtc atattaaggt gacagtaatc agagagactc gagccgtaga 1642681 gtatgcaaaa taaagtgatg cgctaagcat cactttattt ttttgacggc aaggaatttt 1642741 caagaagaaa ggatttacaa aatgagaatt ttatttatcg gagatgttgt cggttcaccg 1642801 ggccgtgaca tggtcaaaga atatgtacca aagctaaaaa caaaatataa gcctcacttt 1642861 accattatta atggtgaaaa cgccgcacat ggaaaaggcc tgacggaaaa aatttatcac 1642921 agcttaatcc agtccggcgc agatgcaatc acaatgggga accacacatg ggacaaaaaa 1642981 gaaatatttg attttataga tgacgttccg aacttggttc gcccggcaaa ctttcctgaa 1643041 ggaacaccgg ggaaagggat cacatatgtg aaagcaaacg gcaaagaact agcagtcatt 1643101 aatttgcagg gacgtacgtt tttgccgccg cttgatgacc cgtttttaaa agcggatgaa 1643161 ttgatcgcag aagctgcgaa aagaacaccg tacattttta ttgactttca tgccgaagcg 1643221 acaagtgaaa agctcgcact tggctggtac acggatggac gggcatcggc tgtagtagga 1643281 actcatacac acgtgcaaac agcggataac cgcattttgc cgaagggaac ggcatatatt 1643341 actgatgtgg gaatgactgg cccgtatgac ggtatactgg ggatggacag agagacgatt 1643401 attaagcgat tcaaaacgaa ccttccagtc cggtttactg tcgctgaagg aaaaacaacg 1643461 ctcagcggag ttgtcattga cattgacgat caaacgaaaa aagccgtgaa aattgagcgt 1643521 attttaatca acgatgatca catgttcttt gaatagttga acatatggtt attttataaa 1643581 aatattaaaa agaaaagcag gaatatagca actccttagt gaatatagta aaaatggaag 1643641 gtagcccgct atttttgaaa agcattgtgg ggatggcttt ttggatagca acatctaata 1643701 atgattgttc taatgaacac tcacttatcc attgtaaaac taagggggag cagaaatgga 1643761 aatcttaaaa gtttcagcaa aatcgagtcc aaattcagtg gcaggtgcgc ttgcaggcgt 1643821 gttgagagag cgaggagccg ccgagattca agcgatcgga gcgggtgcat taaaccaggc 1643881 tgtaaaagct gtggcgattg ccaggggatt tgtggcgcca agcggcgttg atttgatttg 1643941 tattccggct tttacagata ttcaaatcga tggggaagaa agaacagcga ttaaattaat 1644001 cgtggagcct cgctaaaaac aaataaagca ttctcaacct gtttgcgtaa tgcaaacagg 1644061 ttgtttttca tttattgtga tattttctcc cgatagtatt tttagcacat aaatgagcga 1644121 atatacaaaa tcagaaatga gctaaaacgt ttcaaaaaaa atttccgccc atttttcaag 1644181 acagatactt ttgtccttct ggaaaagaca gttctgttta cgcttattcc atatcatggt 1644241 acaatccgaa tataacaaga atttttcaag gaggattgta catgcagagt ggaaagatga 1644301 aagctctaat gaaaaaggac ggggcgttcg gtgctgtgct gactgaagtt cccattcctg 1644361 agattgataa acatgaagtc ctcataaaag tgaaagccgc ttccatatgc ggcacggatg 1644421 tccacattta taattgggat caatgggcac gtcagagaat caaaacaccc tatgttttcg 1644481 gccatgagtt cagcggcatc gtagagggcg tgggagagaa tgtcagcagt gtaaaagtgg 1644541 gagagtatgt gtctgcggaa acacacattg tctgtggtga atgtgtccct tgcctaacag 1644601 gaaaatctca tgtgtgtacc aatactgcta taatcggagt ggacacggca ggctgttttg 1644661 cggagtatgt aaaagttcca gctgataaca tttggagaaa tcccgctgat atggacccgt 1644721 cgattgcttc cattcaagag cctttaggaa atgcagttca taccgtactc gagagccagc 1644781 ctgcaggagg aacgactgca gtcattggat gcggaccgat tggtcttatg gctgttgcgg 1644841 ttgcaaaagc agcaggagct tctcaggtga tagcgattga taagaatgaa tacaggctga 1644901 ggcttgcaaa acaaatggga gcgacttgta ctgtttctat tgaaaaagaa gacccgctca 1644961 aaattgtaag cgctttaacg agtggagaag gagcagatct tgtttgtgag atgtcgggcc 1645021 atccctcagc gattgcccaa ggtcttgcga tggctgcgaa tggcggaaga tttcatattc 1645081 tcagcttgcc ggaacatccg gtgacaattg atttgacgaa taaagtggta tttaaagggc 1645141 ttaccatcca aggaatcaca ggaagaaaaa tgttttcaac atggcgccag gtgtctcagt 1645201 tgatcagttc aaacatgatc gatcttgcac ctgttattac ccatcagttt ccattagagg 1645261 agtttgaaaa aggtttcgaa ctgatgagaa gcgggcagtg cggaaaagta attttaattc 1645321 cataaagggg gataaacatg acgaaggaat ttgagttttt aaaagcagag cttaatagta 1645381 tgaaagaaaa ccatacatgg caagacataa aacagcttga atctatgcag ggcccatctg 1645441 tcacagtgaa tcaccaaaaa gtcattcagc tatcttctaa taattacctc ggattcactt 1645501 cacatcctag actcatcaac gccgcacagg aggccgttca gcagtatgga gccggcaccg 1645561 gatcagtgag aacgattgcg ggtacattta caatgcatca agagcttgag aaaaagctgg 1645621 cagcctttaa aaaaacggag gcggcacttg tattccaatc aggcttcaca acaaaccaag 1645681 gcgtactttc aagtattcta tcaaaagagg acattgtcat ctcagatgaa ttgaaccatg 1645741 cctctattat tgacggaatt cgactgacaa aggcggataa aaaggtgtat cagcacgtca 1645801 atatgagtga tttagagcgg gtgctgagaa agtcaatgaa ttatcggatg cgtctgattg 1645861 tgacagacgg cgtattttcc atggatggca acatagctcc tctgcctgat attgtagagc 1645921 tcgctgagaa atatgacgca tttgtgatgg tggatgacgc ccatgcatcc ggagtacttg 1645981 gcgaaaacgg caggggaacg gtgaatcact tcggtcttga cggcagagtg catattcagg 1646041 tcggaacatt aagcaaggca atcggagtgc tcggcggcta cgctgcaggt tcaaaggtgc 1646101 tgatcgatta tttgcgccat aaaggccgtc catttttatt cagcacatct catccgccgg 1646161 cagtcactgc agcttgtatg gaagcgattg atgtcttgct tgaagagccg gagcatatgg 1646221 agcgcttgtg ggagaatact gcctatttta aagcaatgct tgtgaaaatg ggtctgactc 1646281 tcacgaagag tgaaacgccg attcttccta ttttaatagg tgatgaaggt gtggcaaagc 1646341 aattttcaga tcagctcctt tctcgcggtg tttttgccca aagtatcgtt ttcccgactg 1646401 tagcaaaggg aaaagccaga attcgcacga ttataacagc agagcacacc aaagatgaac 1646461 tggatcaggc gcttgatgtc atcgaaaaga cggcaaagga gctccagcta ttgtaacaag 1646521 aggaagagtt tactcttcct cttttgattc cttattgatt attattctca atgagtgtac 1646581 aatgataggt tgccagttgt gcagagcttc aataaccttt atactgaagg gtggaagttt 1646641 ggtttgaaag gagaaaatat gacatgaatg aaaaacaaaa attagagagc ggacaagttc 1646701 atccatcgga caaaaaatcc gagaaggatt acagcaagta ctttgaagct gtttacattc 1646761 cgccttcttt aaaagacgcg aaaaaacgag gcaaggaagc cgttacttat cataatgact 1646821 ttaaaatttc tgaacaattt aaaggattgg gagacggaag aaagttctat atccgtacgt 1646881 acggctgcca aatgaatgaa cacgatacag aggttatggc agggatcttt atggcgctcg 1646941 gttacgaagc gacaaactct gttgacgatg ccaatgtcat tttgttaaat acatgtgcaa 1647001 tccgtgaaaa tgctgaaaac aaggtgtttg gtgagctcgg gcacttaaaa gcactgaaaa 1647061 aaaacaatcc cgatctgatt ttaggcgtgt gcggctgtat gtcccaagag gaatcagtcg 1647121 tgaaccgtat tttgaaaaaa catccgtttg tcgatatgat tttcggaacg cataacattc 1647181 atcgcctgcc ggagcttttg tcagaagcat acctttcaaa agaaatggtt gtagaagttt 1647241 ggtctaagga aggggacgtt attgaaaacc ttccaaaagt ccgaaatgga aaaattaagg 1647301 gctgggtcaa tatcatgtac ggctgtgaca aattctgtac gtattgcatt gtgccttaca 1647361 cacgcggaaa agaaagaagc cgccgccctg aggatatcat tcaggaagtg agaaggctcg 1647421 caagtgaagg ctataaggaa attactctgt taggccaaaa cgtaaacgcg tatggaaaag 1647481 actttgaaga tatgacgtac ggacttggtg atttgatgga tgaactgaga aaaatcgata 1647541 tcccgagaat ccgttttaca acgagtcatc cgcgcgactt tgacgaccgc ctcattgaag 1647601 tgctggcaaa aggcggaaat ctgcttgatc acattcatct tccggttcaa tcaggaagct 1647661 cagaagttct caagctgatg gcccgcaaat atgacagaga gcgttacatg gagctggtgc 1647721 gaaaaattaa agaagcaatg ccaaacgctt ctttgacaac ggacattatc gtcggatttc 1647781 caaatgaaac ggacgaacag tttgaagaaa cgctttctct ataccgtgaa gtggagtttg 1647841 acagcgccta tacgttcatt tactctccgc gtgaaggcac tccggctgct aagatgaaag 1647901 ataatgtacc gatgcgtgtg aaaaaagaac gcctgcagcg tctaaacgca ctggtgaatg 1647961 aaatttctgc taaaaaaatg aaggaatacg aaggcaaggt tgtcgaagta ttagttgagg 1648021 gtgaaagcaa aaataaccct gatattcttg ctggctatac tgaaaaaagc aagcttgtca 1648081 atttcaaagg gccgaaggaa gccatcggca aaatcgtccg cgtgaaaatc cagcaagcga 1648141 aaacatggtc gcttgacgga gaaatggtag gagaagcaat cgaggtgaaa tgagatgacg 1648201 ctctactcaa aaaaagacat tgtgcagcag gctcgaaacc ttgcaaaaat gatttctgaa 1648261 acagaagagg ttgatttttt caaacgggct gaagcgcaaa tcaatgagaa tgacaaagtg 1648321 tccacaatcg ttaatcagat taaagccctg caaaagcagg ctgtcaatct gaagcattat 1648381 gaaaagcatg aagcgctcaa acaagtagaa gcaaaaattg acgcgctgca agaagagctt 1648441 gaagagattc ctgttatcca ggaattcaga gactcgcaaa tggaagtaaa tgacctactg 1648501 cagctcgttg cacacaccat ttccaaccaa gtcacaaatg aaatcatcac atcaaccgga 1648561 ggcgacctgc tgaaagggga aaccggttca aaggtgaagc attcaaataa cagctgttct 1648621 ctctaaacac ggtgccttta caggcccgtg tttttttatc atttgtgcgg ttaaaaatga 1648681 actaaataat ctatgtacca aatgttcaat tggtttttct gtgctcagcc gcgtataaac 1648741 tttatcgcac ttataagtaa agtttctagg cacccctgca tacaatggaa cagaaacttt 1648801 gtatttttat attttattta taaaaatgca cactagacaa atgcccagca taagataaca 1648861 cgaagaagaa caaggaggca tgccggaatg tctgaataca gggaaattat tacgaaggca 1648921 gtagtagcga aaggccgaaa attcacccaa tgcaccaaca ccatctcgcc tgagaaaaaa 1648981 ccgagcagca ttttgggtgg ttggattatt aaccacaagt atgacgctga aaaaattgga 1649041 aaaacggtag aaattgaagg gtattatgat ataaacgtat ggtactctta cgcggacaac 1649101 acaaagacag aggttgtcac agaacgggta aaatatgtag atgtcattaa actcagatac 1649161 agagacaata attacttaga tgatgagcat gaagtgattg ccaaagtgct tcagcagcca 1649221 aactgccttg aagtgaccat ttcgccgaat ggaaataaaa tcgttgtgca ggcagaaaga 1649281 gaatttttgg cggaagtggt aggggaaaca aaggtagttg ttgaggtcaa tcctgactgg 1649341 gaagaggatg acgaggaaga ttgggaagat gagcttgatg aagagcttga agacatcaac 1649401 ccggagtttt tagtgggaga tcctgaagaa taaaaaaggg actaggggag acagtacccc 1649461 caagtctctt ttttatattg atatatcatt cttttatcac tttttgttta tgttataatg 1649521 aaggttggaa aatagaaacg ttgatacata gtgagggatt aaacaatggc cggttatacg 1649581 cctatgatac agcaatattt aaaaataaag gcagagcacc aggatgcctt tttatttttt 1649641 cgcctgggtg atttttatga aatgtttttt gaggacgcca aaaaagcgtc acaagagctg 1649701 gaaattacgt taacgagcag agacggcggt gcggctgaaa aaataccgat gtgcggtgtg 1649761 ccgtatcatt ctgcttccgc gtatatcgaa cagcttatta aaaaaggata caaagtggcg 1649821 atctgtgaac agacggaaga tccgaaagcc gcaaagggcg ttgtgaaaag agaagtagtt 1649881 cagctgatta cgcccggaac tgtaatggac ggcaaaggca tccatgagtc ggaaaataat 1649941 tttatcgcat ctgtttcagc ctgctcgaac ggatacggac ttgctctgtc tgatttaaca 1650001 acgggagaaa atttggctgt tttgattgaa cggcttgaag acgtcatatc agaaatttat 1650061 tcagtcggcg cacgggaaat cgtggtttca ggaagcttgg atgccgatac agtggcacag 1650121 ctgagagagc ggtgcggtgc aacgatttca attgaagacg gagaaacaga cgaacacgta 1650181 acgatcattg agcacttaaa taatgaagat ataacaaaaa catttctgcg cttatatacg 1650241 tatttgaaaa gaacccaaaa gcgcagcctt gatcatcttc agcccgtgca ggtgtatgag 1650301 cttgaggaag cgatgaaaat tgacttgtac tcaaagcgta atctggagct gaccgaaacg 1650361 attcgttcga aaaataaaaa aggctccctt ttgtggctgc tggatgaaac aaaaacggca 1650421 atgggaggcc ggctacttaa acagtggatt gaccggccgc ttatcagagt caatcaaatc 1650481 gaagagcgcc aagaaatggt ggaaacatta atgtcccatt tctttgaacg ggaagatctg 1650541 cgtgaacgtt taaaagaagt atatgactta gaacgccttg ccggccgcgt tgcattcgga 1650601 aatgtcaatg cccgggattt gattcagctg aaggaatcgt taaagcaagt gcctggcatc 1650661 aaacagctgg ttgcttcact ggctcatgac aaggccaagg aacgtgcaaa gcgcattgac 1650721 ccttgcgggg atgtacttga actgctggaa gaagcgctgt acgaaaaccc tcctttatcg 1650781 gtaaaagaag ggaacctgat taaagatggt tataatcaaa agcttgatga atatcgtgat 1650841 gcaagcagaa acggaaaaga ctggattgcc cgcctggaac agcaggagcg ggaatacaca 1650901 ggcattcgct ctttaaaggt cggctttaat aaagttttcg gttattacat tgaagtgaca 1650961 aaagcaaact tgcatttgct tgaggaaggg cgttatgagc ggaagcagac gttaaccaat 1651021 gcagagcgct acattacacc tgaattaaaa gaaaaagaag cgctcatttt agaggcggaa 1651081 aataacatct gtgagctgga gtacgagctg tttaccgagc tgcgcgagaa agtgaagcag 1651141 tatattccgc ggctgcagca gcttgcaaaa cagatgagcg agctggacgc actgcaatgc 1651201 tttgcgacaa tcagtgaaaa tcgccactac acgaaaccag agttctctaa agatgaagtc 1651261 gaagtgattg aaggcagaca cccggttgtt gaaaaagtca tggacagcca ggaatatgtc 1651321 ccgaacaact gtatgatggg cgataacaga caaatgcttc tcattacagg tccaaacatg 1651381 tcagggaaaa gcacgtatat gagacaaatc gcgctcattt ccattatggc gcaaatcggc 1651441 tgctttgtac ccgcgaaaaa agcggtgctc ccgattttcg atcaaatttt tacgcgaatc 1651501 ggcgctgcag atgatttgat ttccggacaa agtacattta tggtagaaat gcttgaagcg 1651561 aaaaatgcga ttgtcaatgc gacgaaaaac agcctcattc tgtttgatga aatcgggcgg 1651621 ggaacgtcca cttatgacgg catggcgctg gcacaggcga ttattgaata tgttcacgat 1651681 catatcggcg ccaagacgct gttcagcaca cactatcacg agctgaccgt tcttgaggac 1651741 aagctgcccc agctgaaaaa cgttcatgtt cgcgctgaag aatataacgg aacggttgtc 1651801 tttcttcatc aaattaaaga aggtgcggct gataaaagct atggtatcca tgtagctcag 1651861 cttgccgaac tgccgggaga tctgattgcg cgcgctcaag atattttaaa agagcttgag 1651921 cattcaggaa acaaaccgga agtgccggtg cagaaacctc aggtgaaaga agagccggca 1651981 cagctgtcct tttttgacga agcggaaaag ccggctgaaa caccaaagct ttcaaaaaaa 1652041 gaaaagcaag tgatcgatgc tttcaaatca cttaatatac tggatatgac accgcttgaa 1652101 gcgatgaatg aaatgtacaa gctgcaaaag aaattacatt aaaacggggt gatgaatgtg 1652161 gcaaaagtca tccaactgtc agatgagctt tcaaataaaa tagcggcggg cgaggttgtg 1652221 gaacggcccg cctcagtcgt caaagaattg gtggaaaatg cgatcgacgc tgacagcaca 1652281 gtcattgaaa tcgatattga ggaagcaggc cttgcatcca ttcgggtctt ggataacggc 1652341 gaaggaatgg agaatgaaga ttgcaagcga gctttccggc gccacgcaac gagtaaaata 1652401 aaagatgaaa atgatttatt cagggtgaga acgctcggtt tcaggggaga agccctgccg 1652461 agtatcgcgt cagtctctca tctggagatt acaacaagca ctggtgaagg agctgggacg 1652521 aagctcgtcc tccaaggagg aaacatcatt tccgaatcgc gttcctcaag caggaaggga 1652581 actgaaattg tcgtttccaa cctgtttttt aacacaccgg cccgtttgaa atatatgaaa 1652641 accgttcata cagagcttgg aaacattaca gatgtggtta accgtattgc tctggcgcat 1652701 ccagaggtat cgatccgcct gcgccatcat gggaaaaacc tgcttcaaac gaacggaaac 1652761 ggagatgtgc gccatgtact ggcagcgatt tacggcacgg ctgtcgccaa aaaaatgctt 1652821 ccgctgcatg tgagctcctt ggattttgaa gtaaagggat atatcgccct cccagagatt 1652881 acacgggcgt cgagaaacta tatgtcgtct gtggtcaatg gccgttacat taaaaatttc 1652941 ccgctcgtca aagcggttca tgaaggctat catacgcttc tgccgatcgg acgccatccg 1653001 attactttta tagaaattac gatggacccg attttagtcg atgtcaacgt gcatccatcg 1653061 aagcttgagg tccggctcag caaggaaaca gagcttcatg acttaatacg tgacggaatt 1653121 aaagatgtgt ttaaacagca gcagctgatt cctagtgccc aggtcccgaa aaaatcagca 1653181 cctgccatca aaaatgagca gcagtttata acctttgatg aaaagcctcc ggaaaaaaaa 1653241 gttccggaaa aatcgactgc gccatcttat tcaccgatga agctcagctc agtcgtaaaa 1653301 gagccggttg atgcggagga aaaattgccc cctctccaat ttgatgctcc tcctatcgtt 1653361 gatcaggaac aaacccttga ggtgtccgat gtttcagcag aacagcctga aacatttgag 1653421 caggaatgcc atgaggaaca gccgcagcca gcgtctgatc gggttccaat tatgtacccg 1653481 attggccaga tgcacgggac ttatatattg gcacaaaacg aaaacggcct atatattatc 1653541 gaccagcacg ccgcccaaga acgtattaaa tatgagtact tccgtgaaaa ggtgggggag 1653601 gttgagcctg aggtgcagga gatgattgta ccgctgacgt tccactactc cacaaatgag 1653661 gctttgatta ttgaacagca caaacaagag ctcgaaagcg tcggtgtctt tttagagtca 1653721 ttcggctcta acagttacat cgtccgctgc cacccagcct ggtttccaaa gggagaagaa 1653781 gcagagctta tagaagaaat cattcagcag gtgctcgact ccaaaaatat agatattaaa 1653841 aaacttcgcg aggaagcggc gattatgatg agctgcaaag gctccatcaa agcaaatcgc 1653901 cacctcagaa acgacgaaat caaagcgctt ctggacgacc tccgaagcac atcagaccca 1653961 tttacatgcc cgcacggccg cccgatcatc attcaccact cgacatatga gatggaaaag 1654021 atgttcaaac gcgtgatgta gcgggggtgg taggcattga tccattctct gaatggatca 1654081 atgctttttt tgtactcctt cgagtgtcag attataagaa acggttgtaa acgtgtgagc 1654141 agtgttaacg cattatactt catggttcct ccgtataaca aaatttccat ttacaggcaa 1654201 ttgggattaa tgtatatttt gggtgagggg gtggaaacat atggcatgtg gtccgaagat 1654261 cattatcttt ttggatgaac ttgatgatcc aaatgtgaga atcattttag aatgcagaat 1654321 ttaaattaca acattgtgtt ttgctccctg ttcgtgtgaa cagggagatt ttttcgttta 1654381 tataactggt gatgtccaaa tatagggtgt tatgaatttt ccatatctgc catcggcttt 1654441 aagctgcttc tctattaggc tggttatcaa aagcaagttc aatgatagcc atgaaagctg 1654501 atatcacaac aagcaagaca tctggaatat aaatagactg cataaagtaa tctgcaaaac 1654561 agatcgttat aagattgctg ataaaataca gtataaaagc aaaaagtgca gtctttttca 1654621 atgaaagtga ttttgccaaa atgatagaga taatctttgt gagtgggtct atgattaaac 1654681 ctacagcaaa gcaggctaaa ataaataaag ctaatgtttg attggaagcg tatgtgatgc 1654741 caagtatgga gaataagcct ttcatcccga agaaaaagcc gccgaagatg actgcaagcg 1654801 cgatggccgc gataaaagta atagatacaa ttccgattaa ttttgatctc aggttaaaat 1654861 ctttagagtg ctcgttctgt tctttttggt tcatgtatga cactcccttc acctgcttac 1654921 tcatacaaac agcacccttg aatcagccca aaatatctat aagtctgttt tctgacgaaa 1654981 atagtatagc atattttaac aaaaccaaaa aaggcccttt ccactgggga agggcctttt 1655041 tcatcatgtt aactcctgag attcgccgaa gctttctctt tttttggcca aataaaatag 1655101 ctggctgtaa tgagaaagtc aatgcctata atgacagtcc acagtttaag aatgccgctc 1655161 aacgcctcgg ttcgggaaga gtcattgata aaatagatca tccctgccaa tagtcccgca 1655221 ccaattaagt aggccagcac atgtcttagc cagcctttcg caccgtgctt ggcatggtcc 1655281 attccaaaac gtttcagcgg ttttgttcct ttttttgtca cataatattg aaacttttca 1655341 tctgcccatt gaatcatttg tttcccataa gcgatcgata taccgatgta aacagctgca 1655401 atcccatggg ctgcggtcgc tgaggctccg cggtaaaggt ccacaccagt tgccgctaac 1655461 aagatcaaat cgataactgg agttaaggca aggaatagca gtcctaatgt atgtcgtttg 1655521 aatacgtagc gtacagcaag ccccaaaaca atgacaaccc aaaacgcaat ttcacagaaa 1655581 acaatcatcc atgcgatacc gttcaatcca ttcccctctt ttcaatacag ttgtattatt 1655641 taaataatat gttaccatct ttgtttttgt aacacaactg tattataaaa attgccccgc 1655701 ctttgaacga aagctcaaag gcgctacgct gtattatttt gatgaaagtg gctgtcagct 1655761 gtgctggata tcaattgtat atactgcacg atctgttacg accttcaatc cttcgttttc 1655821 ttggtgaata tgaagctcac ctaataaagg aatctcatag gcattttgcg gaagcggtac 1655881 gtttccgtcc tcagtgaatg ttgttccttc gccttctaaa acaagctctt ctttcgcaac 1655941 ataatcatca ggatgattcg tactgcgtat agccactttt tgaaggtgga gaacaatctg 1656001 atccaagtct gatatctctt catcatgggt caattcacct tttctaatat caagcgtctg 1656061 gccgactttt gattccagcc attgagaaag ctgtgtattc gtgtgtgcca tcaatattcc 1656121 tccttttgat ctacacgata ctattcccaa ttgctgcatc ttttacacgg gaaagagccg 1656181 ccccactctt tatgtatgaa acagttcgct gttgagtgcc ttgatatagc gtacggcaga 1656241 acgctggacc gattcgtcgg cattttcttt gacaacttta gagaaagcat tgtaaagccg 1656301 gttgaattga agcggtttta ctttggctgc tatttcttca actttggagg cgggaagggg 1656361 aatgagattt gggtagctgt acataaagct gacccagttt cgatccgccg caaccgtaat 1656421 gatatctccg gtcaatagac agcctttccc ttcattgccc ttgctccaat gcaaaacagc 1656481 accgccttta aaatgtccgc ccagtcggta aaggtccagt cccggcttca tattgagcgt 1656541 ttcccctgac cagaagtgaa tgtgattgct tggccttgtc acccattctt tatcatcctc 1656601 atggatatag atcggcgcct gaaacgcttc agcccactca acctgagtag agtaataatg 1656661 tggatgagac aaggcgatgg cttgaatacc gcctaattcg ttgatttggt caattgtctt 1656721 ttggtcaaga tatgtcatgc aatcccacag cacattgaag cccttatgct gaataagatg 1656781 ggctgtttgt ccaatcgcaa actctggttc agttttgatg ctgtaaagat gctcttcttc 1656841 ctttttaagg atgttttgaa ggtttccttt ctcacgcatg tcttcaaggg ttgtccaagt 1656901 ttgtccatcg ggatgaatat actgtctttc atcctcgcaa atcagacacg agttgggcgg 1656961 atctacagtc tgtgcatgtt gcacaccgca tgtattgcag atataatatg gcactttctt 1657021 cacttccttc atctattttc cattatttta ccttatgatt atgaatattc aaacgaaaaa 1657081 accggcagtt ctgctgagag agaattgccg gcttttgatg atgtttattg gccgggaacg 1657141 gaattttctg cgttgacagc gcccgctccg tagatattcg gatcttcatc tttccatttg 1657201 tccgtgccgt ttttcaaaag ctcttttact tcatcagggg taagatccgg gttttgctga 1657261 agaattaaag ctgcgattcc tgcgcaaatc ggtgttgcca tcgaggttcc tgacattgta 1657321 aagtactgag accctacacg gcttgacttt tggagcttat caatataaga attcggagag 1657381 cgaagggaaa taatattaac acccggcgct aaaatatcgg gcttttcttt cccgtatact 1657441 gtcgggccgc ggcttgagaa ggaagcgaca gtatcatcat cgctgcttgc agtattgtta 1657501 tcgtcaagcg cacctactgt aatcaccttt tcgctcacgc ccgggcttgc aatggtctgc 1657561 gaatcagggc ctgagtttcc ggcagcgaca cagacgacaa tccctgcgct ccacgcttcc 1657621 tcaaccgctc tgactaacgg atcttcctgt tcatgatcat atctaagggc atcgcccccg 1657681 agcgacatgc tcataatatc aatcggttca tcggggttgt cctcattgta ttgaatacac 1657741 cactcaacac cctctataat atctgctaac gttcctgaac cctgcttgtt taataccttt 1657801 acgccgatga gattggcttc cggtgcaggt ccgcggtatt gaccggaaga ggatgcaccg 1657861 ctgcttgcga catcacctgc acagtgtgtg ccatgaccat tatcatcgta cggctctgtt 1657921 ttttgattga ccatgtccgc gaatccgata attcttcctt ctagatcagg atgcgggtag 1657981 attcctgtat cgacaacagc gacagtaaca ccttttcctg tcagggtttg cccgtttctg 1658041 acgacttcct tcgcatggct tgcttcggtt gccgtgtcta aaagcgcttt gacttcgcgg 1658101 tttaaataca ctttacggat attgctgcat tcagagagaa gggaatgtaa tgctgaagga 1658161 gtaacctcgg cgctgcagca gttgattttg ttgaagcggc tttttagctt gctgcgtttt 1658221 tctttttgca gcacctctcc agccatttga aagccggtct cgtgacagcc ttcctcaaat 1658281 tcgataatga ctgacatttt ttttctgttt tgcaatttgg tttcgaaaaa tttatgcaag 1658341 aagcaaggag tccatttgaa gggcttgtaa agttgcaata cggtttcccg taacggccaa 1658401 tctagcttgt gagcatttgc tctcaccatt tgtaccatag agtacccaaa catgtatttt 1658461 cctcctatta taaggttctc tgtatactct atgaacagat gataggtttg gtaagtttgt 1658521 ttgtcctctg taagagacag acaagagttt gtttttctga atctttcgca ttagatacga 1658581 tagattcaga agctgaggaa atcattgggg attgaaaaag aacgtttgtt cgtattataa 1658641 tgtgatcata tcaaactggg aaggggagag caaccgtatg aatttctact tgcaccgatc 1658701 tttggaaagc caaatgccaa tcagcattat atatgaagaa agacggaacg attagtaaaa 1658761 gaacgattat tgtgagacag aaaagcaaaa cgaaaatcaa agcattttgt ttttcgaaac 1658821 aacagatcag aacattttta ttggactcta tcctctcctg tgattttgtg agaacaaata 1658881 agcaaaatct ctattctgca ggccggtaac agctgtccgt ctcagcaacc gggcagcctg 1658941 ttactaaaac cctccttaaa cctatataca tttatttgcc aagtgaggtt gttcctacct 1659001 tttttgtctt tcctctcaac cttttttcac tcttatttga aatgaaccgc taataaccgt 1659061 gacaatcaat tgattttttg aaaccgggaa ctttttcact gatgatattg tgtatacaat 1659121 ggtaagataa aacctattgg ctaaacctca tataatgaac cgcgccattc ttatgaaagg 1659181 agttaaacat gagaagattt ttactaaatg tcatattagt cttagccatt gtcttgttct 1659241 tgagatatgt tcattactca ttggaaccag aaccatcaaa tcagccagat acatattcaa 1659301 atttcagcag cttggcagag aatgagagcc cagccgatta cgatatttca tataatgaga 1659361 aaaaaggaag caaagtctta attatgtctc cgcatggcgg aagaattgaa ggcggagtaa 1659421 gtgagcttgt gcgttatttc aataatgaat actctacata cctatttgaa gggttgaagt 1659481 cccatgataa ccaaacactg cacattacaa gcaccaactt tgatgagcca ttggcaaaaa 1659541 agaaaatcaa ggagcatcaa tatgtggtgg cttttcacgg atataaagga gagaacaaga 1659601 atacccttgt agggggaaca gaccgaaagc gggcgaaaat gattgtgaga gcccttgagc 1659661 ggagagggtt ttccgctgag ttagcgtcgt ctaaaagcgg tcttgctgga ttgaatgccg 1659721 aaaacattaa taaccaaggg gaaacggggc taagtatcca gctggaaatc agccgtgagc 1659781 agagagaagc attttttgat gatttttatt ataaaaatag aaaatacaca aagaacagtg 1659841 aattttatgc ttatgtcagt gcgatcaaag gtgtcctgga aaaagagtat tcgtaacaag 1659901 cagatcagaa gacaaaataa gagaagatca gtagactgaa ataggataaa aaaggaggca 1659961 aaacaatggc agatcatcat ttttatttaa aagcgaactg gccgggtaac cgtaatgatg 1660021 tcggtacgat cgaaagcgga aacctgatca catcgatttc cattcctaaa gaaatggatg 1660081 gcccgggaga agggaccaac ccagatgaaa tgcttctcgg ggcggcagcg acctgttaca 1660141 ttattacact tgcagcgatg atggagagaa gcgggctgga aaaagaagac ttacagatgg 1660201 agtcagaagg cattgtcaac gttacaaaag gagtctttac atacaaaaag atcattcacc 1660261 gtccctctgt cgtgcttaaa catgatgctt cacaagacga cgtcgcattg gcgcacaaac 1660321 tttgtaaaaa agcggagtcg tcatgcatga tttcgcgtgc aattcaagga aatgtcgagc 1660381 tgcagcttga agcctctgtg aaactgggtg gagaataaag aaaacagacg gtcactcaca 1660441 ggccgtctgt tttttatctt cagcgtgggc tttcgattga tttagcacga ccacgcctgc 1660501 aatgacaagc gtgagaccga atacaccttt taaactgatg gtttcgccaa aaagcaaaaa 1660561 cccgacaatt gctgtaagcg cggtaccaac gcccgaccat gttgcatacg cgcttgataa 1660621 gtcaattgtt tttaaagaaa agcttagaaa cgtaaaagca gaaagaaatc cgactatgac 1660681 tccggcaatg ggccaggctt gtgtaaatcc ttctgaaagc ttcaacatcg tgctcccaaa 1660741 cacttcagat acaatggcga gagccaaata aagcaatcct ctcatcttca tcactccttt 1660801 acggccaatt aagtaacacg acccctgata gtaataaaag aatcccgata agccctttgg 1660861 cattcagatc ttccttgaac cattttactc cgatcactgt cgtcagcacc gtgcctgccc 1660921 cgctccaagt cgcataggag aggctcaggg gaatatggtt taaagtcagg gacagcatat 1660981 aaaaggcgag ggaatagcca ataacgacca aagcacttgg cttccacttt ttgaagccat 1661041 cagatacttt cagcatggct gctcctatcg attccgaaca tatggcaatc gtgaggaata 1661101 tatatcctat caacatcatg aattctcctc actatatttt tagattagaa aaaaaacttc 1661161 agctagaaaa atattagtgt atgcctatgt atgagtcaag agattcattt tcacacactt 1661221 aaaaagaccc ctttttaagg ggtcttttgc gtttaataat aaaaagggaa cggggcatac 1661281 ggataatagg ggtatccgcc atacaaataa ggattaaata aagcgcttcc tataagcccg 1661341 cctgcaaggc cgccgataaa cggtcctcca aaaaatccga atggccggcc aaacccataa 1661401 ccaaatccgg gtcttccaaa cccgtaaccg aacccgaacg gtcttccaaa cccaaatggt 1661461 ctcccgaatc cgaacggcct tccaaatatt cttgtatctt cagggctgaa atgctctaac 1661521 tcgttcatgt tttctttcct cctgtaataa agtgtagatg atgcagtgta ttcaccctgc 1661581 ccggatttga ttgggcgaat cgaggaaaag gaggatgtga acacattggg cctgtatcag 1661641 tctgactggt caaaagcacc gccccacgca catgcttatc atgtcaaaac aacgagagaa 1661701 cagggccatt atcatctcat cgaagggttt actcagccgg caaacggatc aaataccgat 1661761 cagcatacac attactatac agggatcact tcatttgaaa acggccattt tcatcggtat 1661821 tacggaatct caggaccggc gattccctta gcagatggca cacattatca tgaaatcgaa 1661881 gaaacgacgt atctggccta taacgagccg attgagatcc agtacggagg ggttgtgtac 1661941 gatcccggag atgacagaag aaaaacgcat cgtcataccc tgaaaggaaa gacaagggaa 1662001 attgtcggca atgagccgct cggctggtag aaggatgttt accgatgcaa aaaaagggca 1662061 aaatggatag gtggttgtcc atgttgaatg ctataatggg gggagattta taaaagagag 1662121 tgatacatat tgaataatac gaagcagccc gttgtcattt tagtcggacc gacggcagtg 1662181 gggaaaacca atttaagtat tcagctagcc aaatccttaa acgcggaaat tatcagcgga 1662241 gattcgatgc agatttataa agggatggat attggaacag ctaaaattac cgaacaggag 1662301 atggagggag tgccccatca tctgattgac attttagatc cccaagactc tttctctact 1662361 gccgattatc aaagcttagt aagaaataaa atcagcgaga ttgcaaatag aggaaagctt 1662421 ccgatgattg tcggcggtac agggctttat atacaatctg tgctttacga ttatacattt 1662481 acggaagagg caaatgatcc cgtgtttcga gagagcatgc aaatggctgc tgagcgggaa 1662541 ggcgctgact ttcttcatgc caaacttgct gcagcagatc ccgaggcagc agctgcgatt 1662601 catccgaata atacaagaag agtcattcgc gcactggaaa ttttacatac gtccggaaaa 1662661 acgatgtccc agcatttgaa ggaacaaaaa cgagaacttc tgtacaatgc agtgttaatt 1662721 ggcctgacaa tggatagaga cacgctttac gaaagaatta atcagcgggt cgatttgatg 1662781 atgcagtcag gccttcttcc ggaagtgaaa cgcttatacg acaagaacgt gagagactgt 1662841 caatcaatac aggcgatagg ctataaagag ctgtatgcat attttgacgg ttttgtgaca 1662901 ctttccgatg ctgtcgaaca gctaaagcag aactcgaggc ggtatgcgaa acgccagctg 1662961 acgtggtttc gcaacaaaat gcaggtcaca tggttcgata tgacaccgcc tgttgatatg 1663021 gagctgaaaa aaaaggaaat tttcacacat atagcaggaa aactcgaact ttaatcgaaa 1663081 ctgtatgata tagagaatca aggaggacga aacatgaaac cgattaatat tcaggatcag 1663141 tttttgaatc aaatccggaa agaaaatacg tatgtcactg tttttttgct gaacggcttt 1663201 cagttgcggg gccaggtgaa aggctttgat aactttaccg tattgttgga atcggaaggt 1663261 aagcagcagc ttatatataa acatgcgatc tcaacgtttg cgccgcaaaa aaacgtccag 1663321 cttgaactcg aatagatcaa aaaatgccat gtcaagacat gaggaaaggc tgtcgggggt 1663381 tcccggcggc catttttaac atgaatccac ttttgctcca agctttttgt gtaagctgac 1663441 catgccaagg cacggtcttt ttttatgaga acaacatacg gaagtaaaaa tggtatatta 1663501 tgtataaaat gaatttggga gtgatcgatc ttgtttgaaa gtgaagcaga actgagacga 1663561 atcaggattg cacttgtatg gatagctgtc tttttactgt tcggggcgtg cgggaatcaa 1663621 gataccatta ttgaaacaga caacggcaat tcagactatg aaacgcctca gcccacctcg 1663681 tttccacttg aacataacca ttttggcgtt atggaggacg gctatatcaa aatttatgag 1663741 tataatgagt cccgcaatga ggtaaagctg aagaaagaat acgcggatga tgagcttgaa 1663801 taaaattcac aagcattcga atttacaaag cggatgccag ccgctaaact aaatacagac 1663861 acagatcaaa cagagggtga aaacatgaag cataaagtga tcgtgaatca ttgggaagaa 1663921 atttgcgaag atgattcttg ctatgaatac ggaacaagta tcattgtgaa cggaaaagaa 1663981 ttaatcagag aagcgtcaat tatcactgct ttgaaggcgg ttttagaaga gatcggcgcg 1664041 gatgttgaaa tagaagaaac agtagagagc gaaaaatgct gtgatagctt aagaaaaaaa 1664101 aatctagact actaagcagt tttttttcat gttatgatat acatcggcta aaaacgacac 1664161 cccgagtagg acgagagatg attctcgttc tgctctcttt tttgggccct aatgagtctg 1664221 cccgtttgcc tgatttgatc aaaatatgaa tttttcataa aaacgaatct atatattgtg 1664281 tttttgctag agggtagtat actatatata gtgttagtga tgagagattc atattttttg 1664341 ataggtcgtg ataaaacgtg gtacaaatca tatttgattc gaaaacaggg aatgttcagc 1664401 ggtttgtgaa taaaacaggc tttcagcaga tacgcaaggt ggacgaaatg gaccacgtgg 1664461 acactccgtt tgttttggtc acctacacga caaacttcgg ccaggtaccg gcatcaacac 1664521 aatcatttct cgaaaaatac gcccatctct tattgggagt cgctgcgagc ggcaacaaag 1664581 tatggggcga taactttgca aaaagcgccg ataccatttc aagacaatat caggtgccga 1664641 tcttgcacaa atttgaactc agcggcacat ctaaagacgt tgaattgttt actcaggagg 1664701 tagaaagagt tgtcacaaaa tcaagtgcca aaatggatcc agttaaataa cgaaatcatg 1664761 atccaaaaag atgggaaatt ccagtttgat aaggataaag aagctgtaca tagctatttt 1664821 gtagattata tcaatcaaaa cacagtcttc tttcacaatt taaaagagaa gctggattat 1664881 ttggttgaaa accaatacta cgaagaggaa ttcttaagcc tttattcttt tgaagacatt 1664941 aaagaagtgt ttaagacagc ttacgctaag aagtttcgtt ttccttcctt catgagtgcg 1665001 tttaaattct ataatgacta tgctttgaaa acgaatgaca agaaaaaaat cctcgagcgt 1665061 tatgaggacc ggatctcaat tgttgcgctg ttcttcgcta acggcgacac tgagaaagca 1665121 aaagaatatg taaacctgat gatcaatcaa gaatatcagc cgagcacacc gacatttttg 1665181 aatgccggca gaaaacgccg cggtgaactt gtgagctgct tcttgctcga agttaatgat 1665241 tctttaaatg acatttcaag agcaatcgat atctccatgc agctttctaa gcttggtggc 1665301 ggggtttctc ttaacctgtc caagcttcgc gcgaaaggtg aagccattaa agatgttgag 1665361 aatgcgacaa aaggcgttgt aggcgtcatg aagcttcttg ataacgcgtt ccgttacgct 1665421 gaccaaatgg gacaaagaca aggctccggc gcggcgtatt taaacatttt ccaccgcgat 1665481 atcaatgatt ttcttgatac gaaaaagatt tctgcggatg aagatgtgcg tgtcaaaacg 1665541 ctttcgatcg gtgttgtcat tccggataag ttcgttgagc ttgcacgcga ggacaaagcg 1665601 gcttatgtat tctacccgca cacgatttat aaagagtacg gccagcacat ggatgagatg 1665661 gacatgaacg aaatgtacga caagtttgtc gacaaccctc gggtgaaaaa ggaaaaaatc 1665721 aacccgcgga aactgcttga aaaattggcg atgcttcgtt ctgaatcagg ctatccatac 1665781 atcatgttcc aagataacgt caataaagtg catgcgaata accatatttc caaggtcaaa 1665841 ttttctaacc tttgctctga agtgctgcag gcatctcaag tttcttcata cacagactat 1665901 gatgaagaag atgaaatcgg tctggatatt tcctgcaacc tgggttcgct taacattctc 1665961 aatgtcatgg agcataaatc aatcgaaaag acagtcaagc ttgcgacaga ctctttaaca 1666021 cacgtgtctg aaacaacaga catccgtaat gcgcctgctg taagacgggc aaacaaagcg 1666081 atgaaatcaa tcggcctcgg tgctatgaac cttcacggct accttgcgca aaacggcatt 1666141 gcgtatgaaa gtccggaagc gcgtgacttt gcaaacacgt tctttatgat ggtgaatttc 1666201 tactccatcc agcgttctgc ggaaatcgca aaagagaagg gcgaaacgtt tgatcaatat 1666261 gaaggatcaa cctatgcgac aggtgaatac ttcgacaaat acgtttcaac tgatttctca 1666321 ccgaaatacg aaaaaatcgc taatctgttt gaaggtatgc atatcccgac gacagaggac 1666381 tggaaaaagc taaaagcatt tgtcgctgaa cacggtatgt atcacagcta cagattatgc 1666441 attgcgccga caggctctat ctcatacgtt caatcaagca cggcgtctgt tatgccgatt 1666501 atggaacgga ttgaagaacg aacatacggc aactcaaaaa cgtactaccc aatgcctggg 1666561 cttgcatcta ataactggtt cttctataaa gaagcctacg atatggacat gttcaaggtt 1666621 gtggatatga tcgccactat ccagcagcac attgatcagg gaatcagctt tacattgttc 1666681 ttaaaagaca caatgacgac ccgagattta aaccgaatcg atctgtatgc acatcataga 1666741 ggaattaaaa ccatttacta tgcaagaacg aaagatactg ggcaagacag ctgcctttct 1666801 tgtgttgttt gattaaagga gagtttatag tgacaaaaat ttatgacgca gcaaactggt 1666861 caaagcatga agacgatttt acccaaatgt tctataacca aaacgtgaaa cagttctggc 1666921 ttccggaaga gattgcttta aacggcgatc tcctcacatg gaagtacctc ggaaaaaatg 1666981 agcaggacac ttatatgaag gtactggccg gacttacgct tcttgacaca gagcagggga 1667041 atacggggat gccgatcgtg gctgaacacg tagatggcca ccagcggaaa gcggtgctga 1667101 actttatggc gatgatggag aacgctgtcc atgcgaagtc gtactctaat attttcatga 1667161 cccttgcacc gactgaaacg atcaatgaag tatttgaatg ggttaaacaa aataaatatt 1667221 tgcagaaaaa agcgcaaatg attgtcgggc tttacaaagc cattcaaaaa gatgatgaaa 1667281 tttcactgtt caaagccatg gttgcttccg tctatctgga aagcttcctt ttctacagcg 1667341 gtttctatta tccgttatat ttctacggac aaggaaaact gatgcaaagc ggtgagatca 1667401 ttaacctgat ccttcgtgac gaagcgattc acggcgtgta tgtcggtctc cttgctcagg 1667461 aaatttataa taaacagaca gaagagaaaa aagcagagct tcgtgaattt gcgatcgacc 1667521 tcctgaatca gttatatgaa aatgagcttg agtatacaga ggacttgtac gatcaagtcg 1667581 ggctctcaca tgatgtaaag aaattcatcc gctataatgc gaataaagcg ctgatgaacc 1667641 ttggatttga tccatacttc gaagaggaag acattaatcc gatcgtttta aacggattaa 1667701 acacaaaaac aaaatcgcat gacttcttct ctatgaaggg gaatggctat aaaaaagcga 1667761 cagttgagcc gctcaaagat gatgactttt attttgaaga tgaaaaagag cagatataat 1667821 atctgctctt ttcggcttga aggttcaaat gaggaggacg cagtacccat gggaaaaatg 1667881 gacgaaatga ttttagttgc cccgcgcgat gatgtgttta aaaaagaaag cttaaccttc 1667941 cagggcgtgt acagtgaaga tagcagagta gcagaaatca tggctcagat tgaagcggcc 1668001 tatcgtgaaa tgagaagagg ggacgcagaa gaagatccgc gtttcaagca gccgatacct 1668061 tatgtcgtca ttaagcgtga agatgaagtt tttctttacg agcggctggc tggcggcggt 1668121 gaatcacgtc tgcacaacaa gctttctctc ggttttggcg gccatatgaa cgccatcgaa 1668181 ggggcagctt catttgctga agtcttaaag ctgaacacag accgtgagct tgaggaagaa 1668241 ctgcaaataa atgaagaaga taaacaggcg attgtcacac tgggattgat caatgatgat 1668301 gaaaacagtg ttggcaaagt gcatatcggt attctttctg cgcttcaatt aaagcctggc 1668361 gcacaagtgg aagtgaagga gaaagaacaa attgcgggta aatggatgaa agtttctgaa 1668421 ttaaaacagg atgatatcta caaccgtctg gaaacatggt cacagtttgt tgttgatatt 1668481 cttgaataaa aaaacccggt ttctcgcgat gaggagccgg gtttttttat gagacgctcg 1668541 tccccgtctc ggctatgatt ctaggatcac aatagcgtca aagccggcat ttttcgctct 1668601 ggcagcgagg gtgtctgcat tgtctttgga tgaaaatgcg ccaatctgca ctttgtataa 1668661 tccgtccttt aaaaggacaa tcgagtcaaa acctttggct tcggcattac ttgcgagcga 1668721 gtcggcattc gctttgactt taaatgcgcc gatttgaacc ttatataacc ctgagctgga 1668781 agtcttttta aggttaaagg cttgctccag cccgtttgca tgtcctctcg ctaagctttg 1668841 aataaaactg ctcgttttca gcttatttgc atcggaaacg gtatcaatga agccgttctc 1668901 ggtcaagagg gcaggcattg ccgactccct taggacgtgg aagttcgctg tttttttgcc 1668961 gcgatcggca aagtcgacag cttgtatcac ttcagagtga attgtcgatt gataagtcgt 1669021 cgtcggggct cctacatctg gataaatata gctttcaaaa cctgtgcctc ccccggaatt 1669081 aacgtgaatg gacaaaaaga aatctgctcc ccagttattt gcggcatttg tccggtcgtt 1669141 taagctgaca tattggtcgc ttgtccggct cagcagcaga gaaacgcctt catattcatt 1669201 agttaatatc gtacgtaagg ctaaagcgat ttgcagggtt aacgttttct cctgaaggcc 1669261 attacctgtt gcgcctggat cagacccgcc atggccagga tcaataaaaa ttttaaccat 1669321 ttttcatcac ctcattacag gatatgaaaa aacacggctt ctgcttgtac gattatcatt 1669381 caactgaaaa atgaggaaat aaccctttca catccagaaa ttatttctcg ggaaagcgca 1669441 caattcaaca tgaagcgaca acagatacgg tccgacatga aatctgtgca tacgccatat 1669501 gtttgtatgt actatgggtt cggttaacct gcactgattc ctgctggttt taagctttgc 1669561 gttcatatta aatcaagcat ttaaaacgta aattgatgag gaaagctcct ttcattaaag 1669621 acaccgcttt ataaatcgaa aaaaagaaaa acacttcagg tatcttaggg cgggtaatac 1669681 gtttcgtaca aaaatcagcc cgttgtatga aaaagaaata atgagaaaga agctcactat 1669741 aatactctga caaaatgatt aaaaacaaaa tctcatggtt tgtccacccc atgtccgtga 1669801 atacaataag aaataaagta tttctcggga aagcgcagga ttccttattg ttcccgaaaa 1669861 aagcaattgt ttcgacacat gataggcgtt tgtcacaatc ggcatccgct tgaatatcat 1669921 atagagagaa cagagaggtg aagatgttgg agcgcgctgt gacttataaa aacaacggac 1669981 agatcaacat tattctgaac gggcaaaagc aggtgctgac gaatgctgag gcagaggcgg 1670041 aatatcaggc tgcattgcaa aaaaacgaag caaagcacgg cattttgaag gaaatcgaaa 1670101 aagagatgag cgcattagtt gggatggagg aaatgaaacg caacatcaag gaaatatacg 1670161 cctggatttt tgtgaaccaa aaacgcgcgg agcaaggctt gaaggttgga aagcaagcgc 1670221 tgcacatgat gtttaaagga aatccgggaa cgggaaaaac gacggttgca cggctcatcg 1670281 gcaagctgtt ctttgaaatg aatgtcctgt caaaaggcca cttaatagaa gcggagcggg 1670341 ctgacctggt cggggagtat atcggacaca ccgcccaaaa gacgagagat ttaatcaaaa 1670401 agtcattagg tggcattttg tttatagacg aagcctactc gctggcaaga ggcggcgaaa 1670461 aggactttgg gaaagaagcg atcgacacac ttgtaaagca tatggaagac aaacagcatg 1670521 agtttatttt gatactcgcc ggatattcac gggaaatgga tcattttctc tcgttaaatc 1670581 ccggactcca atcaagattt cccatctcca ttgattttcc ggattactct gtgacccagc 1670641 tcatggagat tgcgaaacga atgatcgatg aaagggaata ccagctcagt caagaagcgg 1670701 aatggaaatt gaaagattac ttaatgacag tgaaaagcac gacaagtccc attaaattca 1670761 gcaatggacg ttttgtcaga aatgtgatcg aaaaatcgat cagagcacaa gccatgaggc 1670821 ttttaatggg agaccaatac ttaaaaagcg acttgatgac catcaaaagc caagatcttt 1670881 ccattaaaga agaagcatct ggatctgcat agacctctca gtttttgaga ggtctgtttt 1670941 ttgctcgtat ttccgctttt caaagcaatc gatttgtggt atacacatgc agggtttggt 1671001 atgataatac tactgcccaa tatgcaaaag aaaggaacat ccatttgaac gaacaagaaa 1671061 cgattcagga gaaagccatt ttagtcggat gtcagctgcc gcatatcacg gatgagcatt 1671121 ttgaaaattc tatggaagag ctagcatctc tgacgaaaac agcagacgga aaagtactga 1671181 ccagcgtcac acaaaaacgg aacagggctg acgccgctac atatatagga aaagggaagg 1671241 tagaagagct gaaggcactc gtggaagagc ttgaagctga tctcctcatc tttaatgatg 1671301 aactgtcgcc aagtcagctg aagtcattgg caacagcaat tgaagtgaag atgattgacc 1671361 gcacgcaatt gatattagat atttttgcaa agcgggcgag aacgagagaa ggcaaacttc 1671421 aaattgagct ggctcagctg caatatgcac tgccgcgtct gacgggacaa gggatcaacc 1671481 tttcccggca aggcggagga attggggcaa gaggtcccgg ggaaacgaaa ctggaaaccg 1671541 accgccgcca tatcagaaat cgcattcatg aaatcaacac acagctttcc actgtcattc 1671601 gccatagaag ccgataccgt gaaagaagaa agaaaaacgg tgtgcttcaa attgcgcttg 1671661 tcggctatac aaacgcaggg aaatcaacat ggttcaaccg cctgacgagt gctgacagct 1671721 atgaagaaga cctcctgttt gccacgctgg acccgatgac cagaaaaatg gtcctgccaa 1671781 gcggctacag tgttcttctt tcagatacag taggatttat tcaggatctt ccgacgacat 1671841 tgattgctgc attccgctca acgcttgagg aagtaaaaga agcggattta attctgcatt 1671901 taattgattc ttcaaatgag gattatgcgg gacatgaaaa aacagtgctt cggctgcttg 1671961 aggagcttga agcagatgat atcccgatgc tgacggctta caataaacgt gatcaaaaac 1672021 tgcctgattt tataccgacc gccggaaggg atcacattat ggtcagtgcg aaatttgagg 1672081 acgacgctgc agcctttaaa gaagcgattc agcgctattt gcgccaagaa ctgttaacgt 1672141 cttttgaagc acatgtgccg gcaagtgaag ggaagctcct ttccagaatc aaatcggaaa 1672201 cgatggtaga ccgcttctat tttaatgaag aaaatgaaca gtatgacata tccggctatg 1672261 tccaagaaga gcaaagtatc atcggtgaat taaagaagta tatgtaggaa ggaaatataa 1672321 agacatgttt gacacattaa cacacggaga attattgaag aaaacggcaa tggaagtgga 1672381 agcggacatt gccggcattc ataaacaaat agaagaaatc agcgagcgaa atgagtggag 1672441 agtgcttcaa agctatagaa aacacaaagt aagcgacact catttcacgc cgtctactgg 1672501 atacggctat gatgatatcg gaagagacac gcttgaaagc atatatgcgg atgtgtttgg 1672561 cggagaagcg gggcttgtaa ggccgcaaat catttcaggc acacatgcca tctcaattgc 1672621 tttgttcggt gtcctcagac cgggggacga gctcctttat atcacgggca agccgtatga 1672681 tacgctagag gaaattgtgg gcgtcagggg tggagaaaac gctggttcgt taaaggattt 1672741 tcaaatcggc tataatgcgg ttgatctgac gaaagacgga aagatagact atgatgcagt 1672801 cgccgctgcg atcaatccga agacaaaagt aatcggcatt cagcgctcaa aaggatatgc 1672861 gaatcgccct tctttcttaa ttagtgaaat aaaagaaatg atccgttttg taaaagaaat 1672921 caatgaaaat ctgatcgtct ttgtggacaa ctgttacgga gaatttgtgg aagagcttga 1672981 gccttgccat gtcggagccg acctgatggc gggatctctc attaaaaatc ccggcggcgg 1673041 ccttgcgaaa acaggcggct acctcgtcgg aaaagcgaaa tggattgaag cttgctcata 1673101 ccgtatgacg tcacccggca tcggcagaga agcgggggca tctctttact cgctccaaga 1673161 aatgtaccaa ggcttctttt tggcgcctca cgttgtgtct caaagtttaa agggagcggt 1673221 gtttacagcg agattccttg aaaaactcgg cttcacttca aacccgaaat gggatgcgaa 1673281 aagaacggat ttaatacaat ccgttgagtt ttctgacaga gaaaagatga ttgctttttg 1673341 ccaggctatt caatttgcat cgccaatcaa tgctcatgtg acgccttatc cagcctacat 1673401 gcctggatac gaggatgatg tcattatggc agcagggacg tttattcaag gagcaagcat 1673461 cgaattatca gctgatggcc ctatccgccc gccgtatgta gcgtatgttc agggaggatt 1673521 aacctattcg catgtgaaga atgccatatg cagtgcagtg gattcattga tgcaaaagca 1673581 attaatttaa attttttaaa aatttctctg gatttgatgt taagaatcct tacatcgtat 1673641 tgacacataa tataacatca cctataatga aactaagtta agaaaaggag gaaattgaga 1673701 tgagtgataa tattcgccgc tcaatgcctt tatttccaat aggaattgtc atgcagttaa 1673761 ctgagttatc agcaagacaa attcgatatt atgaggaaaa tggactgata tttccagcca 1673821 gaagtgaagg aaatagacga ttattttcat ttcatgatgt agataaactg ttagaaatca 1673881 agcacctgat agaacaaggt gtaaacatgg caggaattaa acagattctg gcgaaagccg 1673941 aagccgagcc agaacaaaaa caaaacgaga agacgaaaaa accaatgaaa catgatctgt 1674001 ccgatgacga actgagacag ctcctgaaaa acgagctcat gcaagccggc cgttttcaaa 1674061 gagggaatac attccgtcaa ggcgacatgt cccgcttctt tcattaatcc gttagcaact 1674121 gttttgctat atacatttac cttttaagag gaggaatttt accaaatggc aaagtacact 1674181 agagaagata tcgaaaaatt agtaaaagaa gaaaacgtga agtatatccg ccttcaattt 1674241 actgacattc ttggaacaat caagaatgtt gagattcctg taagccagct tggaaaagcg 1674301 cttgataata aagtcatgtt tgacggttct tctattgagg gattcgttcg tatcgaagag 1674361 tcagacatgt acctgtatcc agatctaaat acatttgtta tcttcccatg gacagctgaa 1674421 aaaggtaaag tagcacgttt catctgtgat atttacaatc cggatggcac accttttgaa 1674481 ggtgacccgc gaaacaactt aaaacggatt ctgaaagaaa tggaagacct cggcttcagt 1674541 gattttaacc ttgggcctga gcctgaattc ttcttattca aattggacga aaaaggcgag 1674601 ccgacgcttg aactaaacga caaaggcgga tatttcgact tagctccaac tgatttagga 1674661 gaaaactgcc gccgcgatat cgtacttgag cttgaagaga tgggctttga aatcgaagcg 1674721 tctcaccacg aagtagcacc tggtcagcac gaaatcgact ttaaatatgc tggagcagtc 1674781 cgctcttgtg atgacatcca aacatttaaa ctagttgtca aaacaattgc ccgtaaacac 1674841 ggcctgcatg cgacatttat gccaaaacca ttgttcggtg taaacggttc aggtatgcac 1674901 tgcaatctat cactcttcaa aaatggtgtt aacgcattct ttgacgaaaa cgcagatctt 1674961 cagttaagtg aaacagcgaa gcacttcatt gcaggtatcg tgaagcacgc aacaagcttt 1675021 acagcagtaa caaacccgac agtaaactct tacaaacgtc ttgttcctgg ctatgaagca 1675081 ccttgttatg tagcatggag cgcgcaaaac agaagcccgc ttatccgtat cccggcttct 1675141 cgcggcatca gcacacgtgt tgaagtacgc agtgtagacc cagctgcaaa cccatacctt 1675201 gcacttagcg tattgcttgc tgcaggatta gacggaatca aaaacaaact ggaagcgccg 1675261 gctccaatcg accgcaacat ctatgtgatg agcaaagaag agcgcatgga aaacggaatc 1675321 gttgaccttc cagcaacact tgcggaagca ctagaagaat tcaaatcaaa cgaagtcatg 1675381 gtcaaagcgc tgggcgagca cctattcgaa cacttcatcg aagcaaaaga aatcgaatgg 1675441 gatatgttcc gcacgcaagt acatccttgg gaacgcgaac agtatatgtc tcagtattaa 1675501 tatctcaatc ccttggcact aaaagtgtca ggggattttt tatgttaata ggtaataaat 1675561 tatggagcgg catagtgttt aacacagcca ttaatcctca gacagtcaaa tagccatttc 1675621 tactccggtt gaaagcttct ctatttttgc ttcttattta tctttcctgt attgatatat 1675681 gtatgtaggg ttggacttat aacataaact attctggcca ttccgttctt tcaattcatg 1675741 accgggcttg ccatcagcat aaatctaggc taacagtctc catacatcct gtgatcacct 1675801 ttatcaaact cttaaatgca acttaccact aaccaattct ttatttcgca tagatcatct 1675861 ttgtcatgtg tttacacaag aatctgtttt ggactgagac actgaatata acaaaacagt 1675921 caaaaatcaa tatttaattc attctgttta aactttctga aaaagatgtt gaaaaagtcg 1675981 aaaggatttt ataatattaa gtcaagttag tttgtttgat caacaaacta atgaaatgaa 1676041 ctttcattat ccacaagata agatcttact aatatggatg gaagggggat aagagggtcg 1676101 atttaatgga gctaaacaat ataagaaacg aaagaatgag gcttttatcc ttttccaggt 1676161 atataaggta tgacgaaaaa agatgaattt tttgcttgct gatcaccata tttttttgca 1676221 ctgttttgaa agcgctttta taaaagttta ctgaccgtaa attcgagaaa ttgttatacc 1676281 gtttcacact gttccatatt aaaggatcga aaaggggaga aatcatgctc agtgaaaatg 1676341 taaagaagat tagcatggtt gaaaaagttg gatatgcgtc tggagatttt gcttgtaatt 1676401 taatttatgc aacagtgtct acgtatcttt tgttcttcta tacagatgtt tttggtttat 1676461 cggcagcagc agccggtact atgtttttag tggttagaat aatcgacgct ctcgctgatc 1676521 cttttatcgg aacaatagtt gacagaacga acagcagatt tggacgcttt agaccgtatc 1676581 ttttattcgg agcttttcca tttgtcatac tggcaatact ctgttttaca acaccagact 1676641 tttcggatat ggggaaatta atatatgcct atataaccta tgttggcttg tcgcttacat 1676701 acacaacgat aaacgttcca tatggcgcgt taacttctgc aatgactaga aataatcaag 1676761 aagttgttag tataacttct gttcgcatgt tatttgcgaa tcttggggga cttgtcgttg 1676821 cattttttgt tcccttactg gctgcttatt taagcgatac ttccggcaac gagtctcttg 1676881 gctggcaact aaccatgggt attttgggaa tgataggcgg gtgcctttta atcttttgtt 1676941 ttaaaagcac aaaagagcgg gtcactcttc aaaaatccga agagaaaatt aaatttacgg 1677001 atatatttga gcagtttcgt gttaatcgtc cacttgttgt attaagtatt ttctttatta 1677061 ttatttttgg agtgaattcc atcagtaatt cggttggcat ttactacgta acgtataact 1677121 tagaaagaga ggatttggtg aagtggtacg gtttgatagg aagtttaccc gctttggtca 1677181 ttttaccgtt tattccaagg cttcatcaat ttttggggaa aaagaaatta ctaaactatg 1677241 cattattact gaatattata ggcctcttag ctttactgtt tgttccgcca agtaatgttt 1677301 acctcatact tgtctgtcga ttaatcgctg ctgctggaag tctcactgcc gggggatata 1677361 tgtgggcgct tattcctgaa acaattgaat atggagagta caggactggg aaaagaatgg 1677421 gtgggctcat ttacgctata atcggatttt tctttaagtt tggtatggcc ttaggaggag 1677481 ttgttccggg tctggttctt gataagtttg gatatgtagc aaatcaggca caaaccccgg 1677541 cggccttaat ggggatttta attacaacaa ccattattcc cgtgttcttg cttgttctag 1677601 ctttaattga tattaatttc tataacttag atgagaaaaa atataaaaac atggttcgag 1677661 aattagagaa tagagacaaa gtttatttgg atcatattga tgatttcaag gcttaaaaaa 1677721 gaaaataaac tgaggaggag tcccaaatga agattaccaa tcccgtactt aaaggattca 1677781 atcccgatcc aagtatttgt agagcaggag aggattatta tatcgctgta tctacatttg 1677841 agtggtttcc gggagtccag atacaccact caaaagattt agtaaattgg cacttagttg 1677901 cacatccatt acagagagtt tcacaattag acatgaaagg aaacccaaat tcaggtggag 1677961 tttgggcacc atgtttaagc tatagtgatg ggaagttttg gctgatctat acggatgtta 1678021 aggtagtaga tggcgcatgg aaagattgtc acaattattt agttacttgt gaaacgatta 1678081 atggtgattg gagtgagccg attaaattaa atagctcggg gtttgatgct tctttgttcc 1678141 atgatacgga tggaaaaaag tatttattaa atatgttatg ggatcaccgt attgatcggc 1678201 actcatttgg aggaattgtt atacaggaat attctgataa agagcaaaaa ttaatcggta 1678261 aaccaaaagt tatatttgaa ggaactgata gaaaactgac agaagctccg catctttatc 1678321 atatcgggaa ctattattat ttattaactg cagaaggagg aacacggtac gaacatgctg 1678381 ctacaattgc tcgttctgca aatattgagg ggccatatga agttcatccc gataatccaa 1678441 ttttaacgtc atggcatgac ccaggaaatc cattgcaaaa atgtggtcat gcatccattg 1678501 ttcaaacaca tacagatgag tggtatttag ctcatttaac gggacgtcct attcatcctg 1678561 acgatgattc aatttttcag cagagaggat actgtccttt gggcagagaa acagctattc 1678621 aaaaacttta ctggaaagat gaatggccct atgtagtagg tggaaaagaa ggaagcttgg 1678681 aggtagatgc accttctata cccgaaacaa tatttgaagc aacgtacccg gaagttgatg 1678741 aatttgagga ttcaacatta aatataaatt ttcaaacttt aaggattcca ttcacgaatg 1678801 aattaggttc attgactcaa gcgccaaatc atttacgatt attcggtcat gaatcattga 1678861 cctcgacatt tactcaggca tttgtagcca gacgctggca aagtctccat tttgaagccg 1678921 aaactgctgt tgagttttat ccggaaaatt ttcaacaagc cgctgggttg gtgaattact 1678981 acaatacaga gaactggacg gctcttcaag tcacgcatga tgaagaactt gggcgcattc 1679041 ttgaattaac aatatgtgac aacttttctt tttcacagcc attaaataat aaaattgtta 1679101 ttcctcgtga agtaaagtat gtatatttaa gagtaaatat tgaaaaggac aaatattatt 1679161 atttctattc ttttaacaaa gaagattggc acaaaattga cattgcactg gaatcgaaaa 1679221 aattatcaga tgattatatc cgtgggggag gattcttcac aggggccttt gtagggatgc 1679281 aatgccaaga taccagtggt aatcatattc cggccgactt tagatatttt cgttataaag 1679341 aaaaataatt tgcacatgaa aaaggagatt tctattttag aactcctttt tcatatgaga 1679401 aggtgccatg tcactattgc ttcagaaata ctcctagaat aaaaaaactc atctttaaag 1679461 atgagctgtc cattccataa aaaattacat tgtaatcatg tccagaaaat gatcaatcac 1679521 aatggaggac attcctaatg ccggtgcatt ctgtcctaag gaagatggca ataattcata 1679581 gctattgcct aattgggaat aaacccttga tgatacttca cttctcattg aatttaaaac 1679641 cataggatgc gattcaatta tgctatttct taaaattacg gcttgtgggt tgaaagtatt 1679701 tagaatattg gtaaggccta ttcctaaata gaatccaaaa ttttgtaatg catttaaggt 1679761 tccgatatca ttcagatggg cgaggtttat gatatcttga taggacagtt ttttctcttt 1679821 ggtctgaaga gattttaata aagccttctc tgaagcatac aattcccagc atcctcggtt 1679881 tccgcaactg catttaggac cattaaagtc tattgtcata tgtcccattt ctccagagaa 1679941 gccgcttact cctctatata aatgattgtt gataataaca ccgatcccta ttcctgtgct 1680001 gatacttacg taaataatgt tatcgtgatt ttttgcagct ccaaatactt tttctccata 1680061 tgcgccagca tttgcctcat tttcaataaa aacaggcaca ttgtacttct cttgtatcga 1680121 agattttaag tcaatatctc tccagttgga gttcggagtg aaaacaattt tttgatcttt 1680181 atcaatgagt ccaggcacgc aaatacctat accaataagc ccgtacggag attggggcat 1680241 ttgcgtaata aagtgatgaa tcatatcaat caaaatgtct ttcgttattt ctggagaatt 1680301 ggattccaaa tggcggtatt gatcaagaac gattgttcct tcaaggtctg ttaaaatgcc 1680361 attaatataa tccacaccaa catctattcc aacggagtat cctgcctttt tattaaaaac 1680421 aagcatgaca ggtcttcttc cgccacttga ttgtccttga cctatttcaa ataccatact 1680481 ttctttcatt aacgtgttta cctgtgatga gacagttgat ttatttaatc cagtcatttc 1680541 agataatttt gctcttgaaa taggtgaatt tttaaggatt tcttttaata ataacttttg 1680601 atttactttt ttgacaaagg tttgatcagc gatatccact tcatccactc catttgttta 1680661 atctttaaat taagtatcaa catagtacat agcgaatctt ccctttatta tatctaatgt 1680721 gttcataaaa aactaaaaaa aatattgaaa atactgacga ggttatataa gatgaaaata 1680781 agttagtttg tttaaacaac aaactaatag gtgatgtact tactatatga aataaaatgc 1680841 atctgtattt gaatgaattt atttttaagg gggaaatcac atggctcaat ctcattccag 1680901 ttcaatcaac tattttggaa gcgcaaacaa agtggtttac gaagggaaag attcgactaa 1680961 tcctttagca tttaaatatt ataatcctca agaagtaatc ggcggaaaaa cgctgaaaga 1681021 gcatttgcga ttttctattg cctattggca tacatttact gctgatggta cagacgtttt 1681081 tggagcagct acgatgcaaa gaccatggga tcactataaa ggcatggatc tagcgaagat 1681141 gagagtagaa gcagcatttg agatgtttga aaaactagat gcaccattct ttgcttttca 1681201 tgaccgggat attgcaccag aaggcagtac gctaaaagag acaaaccaaa atttagatat 1681261 gatcatgggc atgattaaag attacatgag aaatagcggc gttaagctat tatggaatac 1681321 agcaaacatg tttacgaatc cccgtttcgt ccatggtgcc gcgacttctt gcaatgcaga 1681381 tgtgtttgcg tatgctgcag cacaagtgaa aaaagggtta gaaacagcaa aagagcttgg 1681441 cgctgagaac tatgtatttt ggggcggccg tgaaggatat gaaacattgt taaataccga 1681501 tttaaaattt gagcttgata atttggctag atttatgcat atggcagtgg attatgcgaa 1681561 ggaaatcggg tacacagggc agtttttgat tgagccaaaa ccaaaagagc cgaccaccca 1681621 tcaatacgat acagatgcag caacaaccat tgcctttttg aagcaatatg gcttagacaa 1681681 tcattttaaa ttaaatcttg aagccaatca tgccacatta gccgggcata cattcgaaca 1681741 tgaattacgc atggcaagag tacatggtct gcttggctct gttgacgcaa accagggtca 1681801 tcctctttta ggctgggaca cggatgaatt tccgacggat ttatattcta cgacattagc 1681861 aatgtacgaa atcctgcaaa atggcggcct tggaagcggc ggattaaact ttgacgcgaa 1681921 ggtcagaaga tcttctttcg agcctgatga tctaatatat gcccatattg cagggatgga 1681981 tgcatttgca agaggattga aagttgccca caaattaatc gaagatcgtg tgtttgaaga 1682041 tgtgattcaa catcgttacc gcagctttac tgaagggatt ggtcttgaaa ttatagaagg 1682101 aagagctaat ttccacacac ttgagcaata tgcgctaaat cataaatcaa ttaaaaacga 1682161 atctggaaga caggagaaat taaaagcgat attgaaccaa tacattttag aagtataaca 1682221 ggataagctc cagatcctgc tatcaatacc aagtcactga attacccgtc atgattcctt 1682281 tcctattgct tgttgttatg acgggtaact tctataatta ggatttattt agagtgaatg 1682341 gttttttaaa agggcaagga gtgaaaaaat gaagtatgtc attggaatag atcttggaac 1682401 gagtgctgtt aaaaccattt tagttaacca aaacggcaag gtttgtgcag aaacgtccaa 1682461 aaggtatccg ctcatccaag agaaggcggg atatagtgag caaaatcctg aagactgggt 1682521 tcagcaaaca attgaagcat tggctgaatt ggtttctata tccaatgttc aagccaagga 1682581 tattgacggg ataagctatt cgggacaaat gcatggatta gtactgcttg accaagatcg 1682641 tcaggtgtta cgtaatgcaa ttctttggaa tgataccaga acaacgcctc aatgtataag 1682701 gatgaccgag aaatttggcg atcatcttct tgacatcaca aaaaaccgtg ttttagaagg 1682761 gtttacatta cctaaaatgt tatgggtaaa ggaacatgaa cctgaacttt ttaaaaaaac 1682821 tgctgtgttt ttgcttccga aagactacgt gcgattccgt atgaccggtg tcattcacac 1682881 cgaatactcc gatgcagcag gaactttact tttacatatt actcgcaagg agtggagcaa 1682941 tgatatttgc aatcaaattg gtatttctgc agatatttgt cctccgcttg ttgaatctca 1683001 tgattgtgta ggatcgctgc ttccgcacgt tgccgcgaag accgggctat tagaaaaaac 1683061 aaaagtgtac gctgggggag cagataatgc ttgcggcgct attggagcag gtatcctttc 1683121 ttccggaaaa acattatgca gtattgggac gtcaggggtc atactttcct acgaagaaga 1683181 aaaagaaaga gactttaaag ggaaagtcca cttttttaat catggaaaaa aggattcttt 1683241 ttatacgatg ggcgtcacgc tcgctgcagg atacagcttg gactggttta aaagaacgtt 1683301 tgcaccaaac gaatcgtttg agcaattatt gcagggggtg gaagctattc cgataggagc 1683361 caatggactg ctatacactc cttatttggt tggtgaaaga acgccgcatg ctgattcttc 1683421 tattcgggga agcttgatcg gaatggatgg agcccataat agaaagcatt ttttgagggc 1683481 aataatggaa ggtatcacat tctctttaca tgaatcaatt gagctattcc gcgaagcggg 1683541 aaaatcagtt catactgttg tttctattgg tgggggagct aaaaatgata cgtggctgca 1683601 aatgcaagct gatattttca atacgagggt aattaagtta gaaaatgaac aagggccagc 1683661 tatgggggct gcaatgctgg ctgcctttgg aagcggttgg tttgaatcac ttgaagaatg 1683721 tgcagagcag ttcattcgtg aggctgctgc attttatcca aaggcgcaaa atgttcaaaa 1683781 atataaaaca ctatttgatt tgtataagaa catttacact cacacaaagg atctcaatac 1683841 agctttgaag agctttcgaa aaaactaatg atgttattgt ctggagatca accgaagaac 1683901 aattaatgat caatcatcat caaaggcctt tgataacatg gctgccttct tttgaaaaga 1683961 tggtgagaat aaggtatcgc aacctttaaa cagtattgga gtatccagca gacaaaacga 1684021 acgagtggaa ccgtattttg tcagcgaaca cttcaagaag tggggaagct taggaatgcc 1684081 aatgggtaag atgtatgaaa ccgcgctaac gacggtagag ggatctcttg atttatgaag 1684141 aaataggaag gatgttaaca cacaaataac ccctcacatt gacgtgaagg ggtgtttttt 1684201 attgttacta tacagcggaa attttacagg ctagttgcat gattttagct tgttaagcag 1684261 aatggaacta gactctccat catctctttc tcattctttg gaaactgcat tctgctaggt 1684321 ttgctgcttt ttttaacaaa cagtgttttt ctatttcaca cagccattaa atcctctgtt 1684381 cgtcacataa ccgctcttac tccaaattga cagtttatct gattttgctt cttgctcatc 1684441 tagtctgaat tggtctatgt attttgtgtt aggctcatat acatatgcta ctctggccaa 1684501 tccctctttc aataatgtct cttgaacaga tttgccgtca acataaacgt atgctaacag 1684561 tcttccatac ttatctctgc gatcgccttt atcaaattcc agctgtagct taccgctgtt 1684621 gaccaattct ttatttcgtt tcgacgcatc ctcaccgtat ggttgaacac aagaatttgg 1684681 tttcttcgtc tcaggtgtat caacgagcaa gtagcgaact gtgtctttct ttccgttgta 1684741 aataacctta atcgtatctc catctattgc tctatctaat gtaacattga ccaatttctt 1684801 ctgatttttt gaatgaggcg tgccagcctt ttgttctgtc tgattatatt cattagagtg 1684861 agtatcttga gagacttgct ccgtcccatt agaatctgaa tggtttttgg ctgcgtgatt 1684921 tgatccgcaa gctgccaaag taatacttaa aacgattgcg atcatactga tcaaaatctt 1684981 cttcatattg attccctctt tatcattttc tcttttcgcg attaaacatc atcattataa 1685041 cgatatggac attttttgtg aatggaaaac ttcaagggaa cttataacac tccaaattgc 1685101 caatagttaa cttcacaacg agatgatcaa aacatcacca tcacatagcg gaaataaata 1685161 atcctgaaaa taatattgac tgaaaatgct tttagaatta tgataatatg agaaatgaca 1685221 ataatgtgac aaagacatta ctacaacata acaactaata gcttaggttt attctattgg 1685281 ttaaaaatgt aaacggttac aaatccagag gcgaaaatct aagatagaga tgactttagt 1685341 tttgactcaa tatccacact gaaagagctt attaagtatt cttaaaggca ggggaaatgg 1685401 atatgaatga acatcgaaat cgaaggttga aattaataat gatttcagca acttttggag 1685461 ggcttctctt tggatatgac accggagtta taaatggagc tttacctttt atggcaaggc 1685521 cagatcagct tgatttaaca cctgttacag aagggcttgt tacgagtatt cttttattag 1685581 gtgccgcgtt tggagcgttg ttatgcggaa gattggctga tcgatatggc cgccgtaaaa 1685641 tgatccttaa tctttccttt ttatttttcc tggcatcact gggaacagcg ttagcaccta 1685701 atgttttcat catggcggtc tttcgttttt tactggggct ggctgttgga ggagcctcgg 1685761 cgatggtgcc ggccttttta gcagaaatgg caccgcatga aaagagaggg cgtatggtaa 1685821 cccaaaatga actaatgatt gttggcgggc aatttttagc atatgttttt aatgcgatcc 1685881 tcggtgtaac aatggcaaat acgggacatg tttggagata catgctagtc atttgtgctg 1685941 taccggctat catgttattt gccagtatgc ttaaggtacc agaaagcccc cgatggctaa 1686001 tctccaaagg caaaaacagt gaggcgctgc gagttcttaa acaaattcga gaagataaac 1686061 gtgcagaagc tgaatgtaga gaaattcaag aagcggtaga aaaagataca gcactagaaa 1686121 aggcatcact caaggacttt tctacaccat ggctgcgccg tcttttatgg attggaatcg 1686181 gtgttgccat cgtgaatcaa attacaggtg tgaactcgat tatgtattat ggcacacaaa 1686241 tccttaaaga atctggtttt ggtacaaaag cggctttaat cgctaatatt ggaaatgggc 1686301 tgatatcagt tattgcagtt atatttggga tttggctggt cggaaaagtg agacggcgtc 1686361 caatattatt gattggtttg gcagggacga ctacagcgct cctattgatt gcgattttct 1686421 caattgtgct tgatggatct atggcacttc cttatgtagt gctttctttg accgttttat 1686481 ttcttgcctt tatgcaaggg tgtgtaggac ctgtgacttg gcttgtcata gcggaaatat 1686541 tccctcaaag gttaagagga cttggttctg ggataagtgt ttttttcctt tggatattaa 1686601 actttgtgat cggttttgct ttcccgatct tgcttagctc tgtaggtttg tcttttacat 1686661 tctttatatt tgtggcttta ggtgtattgg caatcggttt tgtgtacaaa ttcatgccgg 1686721 aaacaaaagg gcgtacactt gaagaattag aagagcattt tcgttctcga cacgatcata 1686781 atactcctga acaatcagtt attgaggtat aaatatgttg aaaatctctc ttcttatagg 1686841 agggattttt ttagtttcag aaaaaacaaa atccctctgg tagagggatt ttgattcagc 1686901 attttaagat gttctacacg tataatactg gagttgatac tttaaaaatc tcgccatctc 1686961 ttatataaaa acgagggatg cggcggctta atgtagacac gacttcatag ttaatcgtat 1687021 tgagcatttc agccacttca tcaacggaaa tctcggctcc tttttgctta ccgtaaatca 1687081 cgacttcatc tccttgttta ccttcaccgt tttctcctaa actgaccatg atcatatcca 1687141 ttgttactct tcccgccact ggcactcgtt ttccgcgatg aagaacaaac ccgcgattgg 1687201 aaagggcacg agaatagccg tcagcatagc caatcgggag tgtagcaatt acttcattag 1687261 gttctgcgat gtatgtagca ccatagctaa cggttcgggg ttctgtccgc atggttttca 1687321 cataagcgat gcgtgccttt aaacttaacg caggttcaag cttaacgaga tttagttgtt 1687381 taatataggc tgaaggatat aaaccatata agccgatacc taaacggatc atatcagcgc 1687441 taaattccgg aaatgcgata gctgcagccg tgttgcacat atgcacggtg ggcagctcaa 1687501 tcccctgttt ttttaaaaag ctgagaaaac tgatgaattt ttcatgctgc agctttgtga 1687561 gtgttgtgtc cggttcatca gctgtcgaaa aatgtgtgaa aatccctgtc catctgagga 1687621 atttacttgc ctttaaggct ttcactacct ctaaaagttc ttcctttgtg cgtacaccta 1687681 atcgtcccat gccggtatcc acgttaatat gaatggccag ccggttagca ctcgcttctt 1687741 tttccaatat ctcgtttgct tctttcatcc aatcaacctg aaatgctgat aatgttatat 1687801 tccaagctgc tgacttcttt acacaactaa gggatgtaaa accaagcaca aggataggtg 1687861 ctgtaatccc agctttacgt aaaacgattc cttcctccac actggcaaca gcgagctcac 1687921 tcgccccgtg ttccagtgca tggcgtgcca cttctataga cccgtggcca taaccgttcg 1687981 cttttacaac agccataatt ttgctcttat gtggaatatg acggcggatc gctcgcaaat 1688041 tctttttaac ggcatcaaga ttgacttcga tccaaacttc tcggcaaagc tttatcatca 1688101 acgcttcctt ccttcttatg gattataaat accacctatt gccgcaagaa taaatgttaa 1688161 ttgttggatg attcgatctt attttattca actttatttg aaatcattca acagcaaatc 1688221 catgtgatac gagaaggtgc ctatcaatgt tcgaataata gcaagtacgg gatacatgag 1688281 gcttgtaagt ggggtgttaa tggatgcggc gaccgaggat tacaaaaatg attatttgtt 1688341 ttgggacatt tttttctaag ggtagatgat aacgagaaat ctaatcagga aatacttacc 1688401 gttgttatga acattgaaga accttttaaa tgagaagggc tgaggaaatt ctgtaaaaga 1688461 taatcggttg aaaaggcagt cgattccttg ttccataaac ctaacatcag agtatataat 1688521 tatactcgta ttcacaaaaa tcgtttaagt aaggggtata catgaatagg ggagttagtt 1688581 ttcaaatacc gaatgaatat ggaaattttc tatggagaat actgcagccg gtagaaatag 1688641 ctaattatag gtggcaaacg agtggggaat cttattttgt tgtagaagga gagctcgatg 1688701 atgaggagct ttttcatgac tacgaaattg ttgagggggc agtttttgag caacaattaa 1688761 aaacgaatca gtactatacc attttcgttg aactgaaagc atttccatat ggaaaaatgg 1688821 ttaatcaagt caatacatat gaagagtttg ctgacagtga ttgcgaactt gtccttttga 1688881 tagcagataa tagctacgtt tcgatttact gtaaaaacaa aaatatcatt gaaaaacttt 1688941 acttcaatgc tttacagcat gattttgaag acgttcaatt tataactgat gaaaatgaca 1689001 caagaacaag ccttactgta tgatactcaa taaaaattaa aggagctagt acatgacaat 1689061 gcaaattaaa atcaagtatc tagatgaaac acaaacaaga atcagcaaaa ttgagcaggg 1689121 agactggatt gatcttcggg cagctgaaga tgtaacaatc aaaaaagatg aatttaagct 1689181 tgtcccatta ggtgttgcaa tggagctgcc tgaaggttac gaagcacatg tcgtccctcg 1689241 ttcaagtaca tataagaact ttggcgttat tcaaacaaat tcaatgggtg ttatcgatga 1689301 gtcatataag ggagacaacg atttctggtt ctttcctgct tatgcattgc gtgatactga 1689361 aattaagaag ggtgatcgta tctgccagtt tagaatcatg aagaaaatgc cggcggttga 1689421 attggttgaa gtcgagcatt tgggaaacga ggatagagga ggactcggtt caacaggtac 1689481 gaagtaaaca aaataaatcc ttggctgtct tcatgctgtg tgattgatca atggaggttt 1689541 cagccaaggt acatataaat attatgtata aaatgaatat tttaatacga aggatttaat 1689601 taaaaacaaa gtttaaaaag ggaagttttg aaaaagtgaa atagtaataa ctaaagtcga 1689661 taaagaacct aaagatgtca aagaaacaat ttttctggtg ctttgctttt ttgaaggttt 1689721 acttagctcg tggataactg ccccccataa aagcatggat gctaaaatta taatacttat 1689781 atacataaag atgctccttt tattatattt acagttttta catttttatc gattttacca 1689841 catttaggat tgagttgtcg atgaaacaag catctctata aagaaatact tttatctaaa 1689901 tttttataaa taggggaagg caactaaaaa ctagtaatgc cactaataat aagccaagtt 1689961 aaatgacttg tgttcattaa taattgaatt ttacagcagc catgagcaca aaaaaatctg 1690021 agttcgtcga taaatatcat aaaaaagccc ccggtatgtc gccagggaat aaatagacgt 1690081 ttaagagatt tagtgatgtt ttttatatga ttcgacaaaa tcataataat gatcatcgtc 1690141 atcataatac tttttttcgt aatgataatc gtgatcatcg taatactttt tatcatggtc 1690201 atcatacttt ttgtcgtaat cataatgttt tttatcatga tcataatact tgtcgcaatc 1690261 ataatgcttc ttatcattgt cgtaatactt tttgtaatat gtttttttcc aagtataata 1690321 ctcttcttta tattttttat aataacccaa ttaaattcct cctttatgtt attcgaattt 1690381 aatttatgaa gtttaaatga tatggtatgg tcaaatgaaa taagaatagt aaaaagaggc 1690441 tgtttaaaac actttctgaa aaacaaaacg gatagctgtt tatgaaaata agagcgagag 1690501 agagcactca atcactgtaa aataatagta aagtgtatag agagattagt atacgtaaaa 1690561 agggactttc tcattgaaga atatttgaac gttatggtta agattcaaga gctctatgat 1690621 gtgatttttc acactgcttt tgaaggattt agagttagac atcaaaaaca aacagcaaaa 1690681 ccggctagaa acagatcata taaggaatga accgctgcca aatatcataa aaaagttgtt 1690741 aatgatcaaa tgaatgaaat tagagagaat ttattttaaa gaaagcccaa ttgcacatgg 1690801 acaaatgaca attgatattg aggtaaaata caatgcatta aatcagaaaa agctattgga 1690861 ggatttaatg tgtttagaca atttccaatt tggtatacac aaacacctga ctatttgaat 1690921 ttttatgtac cgcaatatca aaccatttcg tataatcctc aacaatgtta tcaacggtgt 1690981 atgtaccaaa ctggcggtaa ctatgagcta tgtgacagac tatgttatgg agaaatacag 1691041 gtgtaaaaga gggggattaa ctcctcttta aacacacagt gagtggaata agatcctcac 1691101 tttatctgca agtgcttagt atttgcgata atattgcatt cgtaataaat tatgcttagc 1691161 aactgaaaat gaaagaagga tatgaatagt catgacgcaa ttcgataaac aatacaattc 1691221 aattataaag gatattatca ataatggaat ctcagacgaa gagtttgatg taagaaccaa 1691281 gtgggactca gatggaacac cggcacatac tctaagtgta atcagtaagc aaatgagatt 1691341 cgacaactca gaggttccga ttttaacgac aaaaaaggtt gcctggaaaa cagccattaa 1691401 agagttgctc tggatttggc agctgaaatc taatgatgtt aatgatttaa acatgatggg 1691461 cgtccatatt tgggatcagt ggaaacaaga agacggaacc atcggacatg catatggatt 1691521 tcagctgggg aagaaaaaca gaagtctaaa tggagaaaaa gtggatcagg tagactatct 1691581 tcttcatcaa ttgaagaaca atccatcttc acgcagacac attacaatgc tgtggaatcc 1691641 tgatgaatta gacgcaatgg ccttaacgcc atgtgtatac gagacacaat ggtacgttaa 1691701 acatgggaaa ctccaccttg aggtaagagc acggagcaat gatatggcat tgggaaatcc 1691761 attcaatgta ttccagtata atgtgttgca gcgcatgatt gctcaagtga ctggttatga 1691821 gcttggtgaa tatatcttta acattgggga ttgccatgtg tacacacgtc atatagacaa 1691881 tttgaaaatt caaatggaaa gagaacagtt tgaagcacct gaactatgga tcaatcctga 1691941 agtgaaagat ttttatgact ttaccattga tgatttcaag ttaatcaact ataaacatgg 1692001 ggacaagctt ttatttgagg tagcggttta atgctgcctt tttattgtgc agtgaataga 1692061 tagcaggtat cctaatttca ttaagcaatc tggaagatga ataaaaattg aaggacaaac 1692121 acgtataata cataaaaaag attaactcta cagttaatct tttttattca gaagaaaata 1692181 tcctaacttt gaaactaaat acaaagtaaa agcaatcatt acagttctag atattacaat 1692241 tccatgaata gctagatcat atccagcagg tatcaacgca tttgtattac acataaaata 1692301 tatagatatt agaagtgcta caataactaa aatcattcca aaaagacttg ttttttcata 1692361 tttcatacca atttccaccc ttattaaagt taggtttaaa caaaagagct gaagaaacga 1692421 actatgacca gtatgctcca aggaaaaccg ccagacaatg ctggcggctt tttgctgctt 1692481 cgtttattta ttaacagaga tcgtaacgtt atttcctgca actgaaacct ttgcgaaatc 1692541 ctgtgtatct accacaggag tgacggcttt attgtcgata gtgatgttgt taaaagaggt 1692601 cgaaaaggtt gctttgatcg catcacgctg gctttcatac gaaacagccg cggtagcaag 1692661 tgttttccat tttgaaatcg tgccgatgtt ggttccttga atttctgtga taatccgtcc 1692721 ggtgtagccg tcattgttcg ttccccaaag ggtcatgcgc gtattgccgc ttaaattttt 1692781 atagattgtc atttggactg tgcttccagg gcggaagcct ttattgtatg tgaatttgtc 1692841 ttttccttcg atgtacgttt cttcattttt ggacccaacc ttcatgaggg gcttccagac 1692901 gttgtattgt ttgctgtact gaagcccgat atcggcttca gttccgcttg ttgccctaaa 1692961 gccagaataa atatagggag tagagaccga gtcgttgttt ttgacagttt caggaagcac 1693021 gattttagct gtaaaaacgg cgcccgtact gttcaggtag acacggccgc cgattccgtt 1693081 aggcagctcg gatgctgctt ttgcgacttg agcgtctgcc gcgggtaaac ctggtatacc 1693141 tgatgaaagg gttccgaaaa gaactgctgt tcctactgca cctgcaatca atactttttt 1693201 caccaaaatt cccccttttg atagtggttt cgccatttat tataccttat tttggaactg 1693261 gatttacgta tataaatcga caaaatattt cattttgaat gatgtaaggt cgaaacgctt 1693321 cgccaatctg aaagctatat acctttatca gaggaaagaa tgagatcaca ttcgttttaa 1693381 ccgatttgaa attttcctca aaataaaagt acaaatgctt aaagaaacga ttattaaaag 1693441 aatgcccgct atcgtttcca agcctgtaaa aaagaggtga cgtttcatca atgtctgtcc 1693501 ttgtaaaatg ataaaagcac agataccgac taagaaaaga aaacaaatac ttaggattgc 1693561 taacgcttta cgtgagtatg ttttcatttc atctttaaaa tacagcaata cgaaaataaa 1693621 gcagataaca ttggctattg ttctaatcac ctcaaagctt ttcatgacaa ctgatataaa 1693681 tagacaaagt aaaatgagat aaaatacgat gtttctatac aaaaaacctc tccttttatg 1693741 taggatcctc aaagagttta taaaagtttc tttgtaactg caataaattg aatgcgctca 1693801 cttatgaact aactaaacta tgtactaaat attcactatt ctttttcaga ttcagtcacc 1693861 aaggttttca tagaaaggga agcttcagaa atatacatat agtgcacaaa caaaaaagac 1693921 ccggcaatag ccgggggaaa gtaaaaacga ggagatgtta atggcgttta gtagtgtttt 1693981 ttatgctttt tatactctac aacataatca tagtcttttt tatcgtgatc ataatatttt 1694041 ttatcatagt catcatattt tttgtcgtaa tcacagtcat aatctttttt atcatattcg 1694101 taatacttct tataatacgt ttttttgacc gtataatact cttctttgta ttttttgtaa 1694161 taacccatat atactcctcc tttattttta ctacgcttta ttatacggcg agtagatttt 1694221 gcggcttgga cagttaaaat catagaagga aaaaagggct gtccaaatga tagaaaaaga 1694281 cagatgacac aaaaacaaat caaaataaag agccgatttt tcatcggccc aaacgattta 1694341 tcctacattt gtttgtcttc tttgttttct gagtcatttt ttctgatatc ctgagtcagt 1694401 ccgcttgttg cttgtttaaa ttctgataag gcttttcctg ctgcacggcc aagcgccggc 1694461 agtttatcag gcccaaatac taaaaaaccc acaaacaaaa taacgagtat ttttgtgaag 1694521 cttaattcca tatccttttc cccctgattg aagtacaacc ttttaaacaa attataagag 1694581 atagcagtac aaatgggaat gcatttattt tgaacatttt aaaaccagca caaagacgga 1694641 ttcataaaac ggctgctgct gaatataatg tccaatgcca cctgcctaag aagcaggagg 1694701 caggctggat caattatgta gctctgccgg aaatgataca aacgtagcgg ctatcattga 1694761 catagaggag tggtgtagct gatgagattc actaaggtag ttggattttt gtctgtttta 1694821 gggttggctg cggtttttcc attaacggca caagcagaaa aagccggaac tgcgggggct 1694881 ggagagtggg ataagttggg gacttacaca tatacttact caagtccgac ggtatactcg 1694941 accggaggag attttagagt gtgcctttca ggaagcactc ctttttctgt ttcactgcac 1695001 ttatatgagg atgatcccgg tgacaatcct gatgattatg taggggcaaa ctatttttca 1695061 cccggagaat gccacacctt tggcagtatt ggaaaatttg tagatgggag caataacaag 1695121 gccgagttct ttgttaccga ttactctggt aaatctaaaa ctgttacgtt ttatgattga 1695181 tggactcaaa ttgtgaagta taacccttgg aaaaaaacaa aaaagagaga tacctctctc 1695241 ttttttattc ttcgacagcc ttacgaagcc gttcatttac aatgccagtc cagccgccat 1695301 ccatcttacc gcgaacgacg gagcttttct cgtttgcttt gccgatcact tcattcggct 1695361 ctttccagcc gctgtgaata agggtaaacc ctgtcttttc ccccaagtct tctaattgaa 1695421 aggtaacgac ccatccttct gtatcccatt caaaagaaag ttcagttgga gcttgaacag 1695481 ccaaaacttt acaaggggac ggcccaaacg gcgattgtaa gtgaaattct tgtccttctt 1695541 tgagctgaaa gtcattgggc ataaaccact tggcaatgcc ttctgaagta gagactgtct 1695601 cccagacttt ctgaatggga gcctccagag taatgctttt tgtaatatcc ggtaatgcat 1695661 tttcgttgtt ttgagccatt tcgtttacct cttgacatat gatgtttttt caattcaatc 1695721 atataataac taataagatc atgtccatag cgtgcattat ttatgctaga gctgctgttg 1695781 aacagcgtgt cagtcgccag tctgatctgt gaatgggaga attctgcatg cgcgaaaaag 1695841 agagagaggt gtatgttgtc atttcgttca ttcttgtttg cagccgcaac tgttatgttt 1695901 gaactgggat tcctgttcag ccaatttatt ttgcgatttt tgttttaata gtaaatgagc 1695961 cattttctaa aacaggaggt tttttatgct tggaaaaatc aaagcagcca ttgataatag 1696021 tccagggaag ccggccagaa ttttagttag tgaaaaagcg tttcagcaat tagaggaaga 1696081 aatgcgcttt gtttacgttt ccaaaccgaa aacgataatg gggattcctg tggaagtttc 1696141 agatcaggca gaaagcttca agctggaatt ttagttttcc cagactgcta aaaggctcat 1696201 tttgtgttaa ttatgcaaaa tggtcaggtt gatttcttta aaagcatgat gaaatgttca 1696261 tcatgctttt ttattgagaa aaaagacgaa cataaaaaat aggtatacgg gaaaaataat 1696321 cctattagag agaggggaac tgacagatgg ataacatgat atcaacactt actgactgga 1696381 atgtgtggtt tcaagcgtta gtagtatttc tcgttccata tgtaatctat aaagtgttta 1696441 cttggattca tgtataagaa ggtgcaatga tgaggtggcg gaacaatcag tacaaaacac 1696501 agaagcagca taaatcagat tattcgacag ctgaaaagca ggatcaggat gtgttaaccg 1696561 gtaacatcgg atacgactta gaacatgtaa aaagaaaaat aggacataac ggggacgttc 1696621 atttccgtga gcttgaaatc actcaattac atgtgaaagc ggcattgatc tttgttgaag 1696681 gactgtctga tcaggacttg attaataaag gactatcagt gttagtcatg aatcaaccta 1696741 atcaggtaag cgatgaaatt tctcaatccg gcaaaggtat tttaacttcg aaacagataa 1696801 aaaatcaaat cgtatcaatc ggtgatgtca tagattcaga gaaaatcagt gatatcgtgt 1696861 tgaatgtttt catgggttcg acagcgcttc tcatcgatgg aataccgcag gcctttcttc 1696921 tgggaactgt aaaaaaacaa aatcgaagta tcgaggagcc gctttcagaa gcgcttgtca 1696981 gagggccgcg cacaggcttt acagaagagt tgagtacgaa tacagctctt ttgagacagc 1697041 aaggaaaaaa tgatcaatta acattgcaga gatttgaagt aggaacacga ttaaaaaagg 1697101 atttaattat cgcttatatg aatgacattg cagatccaaa agtagtcgag gaagtaagaa 1697161 aaagagtgag agggattgag atcgatcatt tgccggagtc aggctacgtt gaacagttaa 1697221 ttgaggataa ttatttgagc ccgttcccgc aagtacagag tacagaacgt cctgatcgcg 1697281 tcataagcgg attaatggaa ggaagagtag ctattctgct tgacggcact ccgtttgctt 1697341 tgattgttcc agtcactttc agcatgatgc ttcaatcgcc tgaagattat tatgaacggt 1697401 ggttcccgag ctcgctcatc agattgctga ggttcatcgc agcaatgata acgttattcg 1697461 cacccgcttt atatatatca tttatttctt ttcatcctgg gttaattccg accaagctgg 1697521 cgatttcaat ttccgggacg cgccaaggtg ttccgttccc atctctgatt gaagccttat 1697581 ttatggaagt cgcgattgaa attttaagag aggcggggct tcgtttgcca aaaccaattg 1697641 gacccgcaat aggcatagtt ggcggattaa tcatcgggga agcagctgtg caggcgggga 1697701 ttgtcagtcc aatcatggtc attgttgttg cgctcacagc aatttcttca tttgccatcc 1697761 cgcattatag cacaggtata gcacttcgga tgcttcggtt tggcgcgatg ttttgtgcgg 1697821 cggtgtttgg attgtttgga gtcattatgt attatctgct gctaagcagc catgtcgtaa 1697881 agctaaagag ctttggtgtg ccatacgcaa gtccggcagt gccctatcac ttaaaagatt 1697941 ggaaagactt tgttatcaga atgcctcttt tagtcatgaa gcgccggcct aaaatgatga 1698001 atacagataa tacaaaacgg gtgaagtgat gaactcgaca ggatggtgat aaagtctcat 1698061 gttcagccca accagtaaaa tcacaaccgc tcaggcaacg attatcatca ttaattatat 1698121 gcttgctgcc ggagttctta cgctccctcg gacagtaaca gaacaaacac aatctcctga 1698181 tggatggatt tcagttttat taggcggggt cctagcggta atagccggga tgattatagc 1698241 taaattaagc cagcagtatc ctaaggagac cttttatgaa tactcccgac atattgtagg 1698301 aaaatggctc gggcatctga tcagtattgt ttttattact tattttctgg cactcggtgc 1698361 atttgaagtc agagtcatgt ccgaaatcgt ggattttttt ctcctcgaag ggacaccttc 1698421 ttgggccatc attatgacag ttctttggat tgggctttat tcaattacac aaggcctaga 1698481 tccgattgca cggctttttg aaatgatttt tccgattacg gtcatcatct ttttaacgat 1698541 agccctcatg agtttaggca tatttgagat caacaatttg cgccctgtat taggtgatgg 1698601 aatcatgccg gttcttagag gtgtaaagac aacgaacctt tcatttacat gttcagaaat 1698661 tatgttcatt ttagtagcat ttatgaaaaa gccgaaaaat gcggtgaaag cagttgtgat 1698721 cgggacaggc gttgtgacca gtttttatat gattacgatg attatggtca tcggtgcact 1698781 atcagttgag ggagttgtga cgagaacatg gccggggctt gacctgatga gaagttttga 1698841 aatacctggt ttaatatttg aacggtttga atcatttctg cttgtgattt ggattatgca 1698901 gctttttgcc acgtttatta tcacttttta tgcagcttcc ctgggagtct cacaagtttt 1698961 taaaaagaaa cccctttcat gtatgtttgg gctgcttcct gttatatata tcctctcttg 1699021 catgccgaaa aatgaaaatg acgtctttat attgggcgat acggtcagtc atatcgcttt 1699081 gtatatattt ggcgctttgc cgattttgct gttagtcatt tcgaaatgga ggaaaagagg 1699141 tgaaaagtaa actaaaacgt caattgcctg ctatggtcat agtatgtctg ctgatgattt 1699201 gcgtaacagg atgctggagc agtcgggaaa tagaagatct gggtctcaca ttcgctatcg 1699261 caattgataa aggaaaagaa acgaacactg aaaaagagtt aaaagaagag ggcgggagct 1699321 atccgaaaaa agacaacatt acgctgacct atcaatttgt taatgaaaaa gcggcaggcg 1699381 cgggcacaag cgggggaggc ggtagcggac aaggagcgca aaaagcgtac attaatataa 1699441 gtgaaacagg ggattcatta cagcagatcg gaagtgaggt tgcattaaga cgggaccgag 1699501 aagtgtttag cccgcattta aaagttgttg tcatgagtga agatgtgctg cacacatttc 1699561 ctatcgacga aatgctggat caattttttc gtgataatga aatcaggctg agctgtcttg 1699621 ttttatctgc taaaggggaa gcaagagacg ctctccagct gaaagagaac ggagaaattc 1699681 cggcatttcg gctgattgga ttaggtgaaa atgaacataa agtttccaga attcttcccc 1699741 ctatgacact cgcgaaacta attggaaaac tgcattctgg cagcagcttt ttactgcaaa 1699801 atgtggttgc ggcgaatgga gcggtcaagt attccggagc agctgtaatc aacggaaaat 1699861 cgaaaaaaat gataggcacc ttaaatgaat atgaaactga ggggattaca tggattagag 1699921 gagaagggaa aggcggagtt gtcaaaagtc atgataaaaa gagccaacag acgttagcgt 1699981 acgatatcaa taaaatcaaa agcagaattc agccaatcgt aaaagggaaa gatatttcat 1700041 tccatgtcga tattgaatca gaaggcgatt tggttgaaaa ctggaacaca aaagaggcgt 1700101 tggacaccca gtttatagat cgtctcgaaa cgactattga aaacgaggta aagaaaatag 1700161 ttggtcaggt attaaaaaaa attcagcatg attataaagc agatgttgcg ggttttgatg 1700221 aatcttttag acttacatat cctcacttat ggaaaagggt gaaaaataac tgggatgaca 1700281 ccttcagtaa agccgacatc acatacagtg tgaacgtcac aattactcat ttcggcacgg 1700341 ttaaaactca gtaatgaatc ccaaggaaga gaaggaaacc tctcttctct tttttatgca 1700401 tttattagga taaagatact ttttttggag agatatacac ttttcaaatc gaccaatatg 1700461 ctaatatagg aattgcttga aatagaaggg agaaggggct gtgaggcaga aaccgattta 1700521 tgtagaaatc gaaatgaaat ctgatctgga tacactctgg gaatatacac aaaacccatc 1700581 actgcataag gaatgggatc tccggttttc aaatattacg tatttgaata gtcagccatg 1700641 cgaaaaacag aagtttcttt acgaaacaag ggtaggcttt ggattaaagg tgtcaggtac 1700701 aggagaaacc gtcggtgttt tcaacaaatg ttcatctgaa aggtcttctt cactggcttt 1700761 tggctctgat catccattat ctctgattcg gcatggaagc ggctactgga agtatataca 1700821 gagagaaaat gggaaaatga cgtttttaac acagtaccaa tacaaaacag cctacggact 1700881 gctgggaaga tggattgatc gtttattatt tcggccgctg cttggctggg cgactgcctg 1700941 gagctttgat gcattaaggc tttgggtaga gcaaaataaa catccgaagc gcttcattcg 1701001 atctgctatc atctatgtgt tcatgtgtct gtttttcagc ctgttttggt tctatcaagg 1701061 ctttgcaggt gttaagacaa gcatattgac aggaacagcg gagataggct tagctatttt 1701121 gtggctgctt cctttaaaaa gaaaatggat cattcatggt gtccaggctt gtatttttgc 1701181 tgggtttgct tgtctaggtt ccgaaatatt catgtgggtt ctattgagtg tgttttccgc 1701241 tgcaagcggc gctcttagcc tgcagctccc cagtgccagg cgcacaaaac gaaagagaaa 1701301 gaagtgacat tgtgagttcg atttatgaaa aatcaattat taactatcat ttgctgcatc 1701361 ccaagctgca gaaacggtac caattagacg ggtctcatac attcagcggg acgggaacga 1701421 tgtcagaaat aagcggaggc tcttttctgg ttagaatgct gttaaagctg ggtgtttttt 1701481 tcagatgctt cttttcagaa agaggcaaag acattccatt tacaatacaa aatagaactt 1701541 gtcttttgaa atcgcaacat acaggaatag aatggaatcg tacatttttc tttaaaggca 1701601 aaaaacgttt ctttgatgcg ttaatgatat atgacgagaa agaaaataga atacttgatt 1701661 tcttcggcaa acctcatctg ctgctgtctg ttttgacgtt cgaggcatct cttgacggct 1701721 ctcttacgat cacatcggga aagcaatggc tattgatatg cggaaaaaga atcccgctgc 1701781 cgaaatggct gaccggtaca tccgaagttt gcgaaacgtt tgatgaaaaa aagaattgtt 1701841 tcaccattga agtgcatgtg caaaatacaa ttcttggcac tcttttcttt tataagggaa 1701901 cgtttcagga ggaagagaga gaatcatgaa acgaaatggc atagtcagtg cgctttgttt 1701961 tattggattt cttgcagcag aagcaccgga tatttcagtg gcagaggcac tcgttttgtt 1702021 atccattcta tttttcgtgc cgggaatttt tccttttgtt tttcgtcaat ctccggttcg 1702081 tgctgctcag tttatggaaa acgggctaat ccagtgctat cctgtagccg cattctttgc 1702141 ggtgctggct ctagtgacgg aggttggggg tttcgcactt atctggtgga tgtacacagt 1702201 ttttaatgca ttgtatgcga tcctccgcct ttgggaaaca aagatacata gaatcgaaga 1702261 gacatcagtt ttgttcggtc ttatttattt ggcgggagga ggattttggt tttttgctta 1702321 tgctgcccat ttgcagatca tgcaatttgg ccctctcatc attttgctga ctgctgtcca 1702381 ctttcactat tctgcttttc tgatcccgat cttcaacggt ttactcggca gaaccattag 1702441 aaaacatcgg atgttgtaca gttggataac atgggtgatt ttgctttcgc cccttcttat 1702501 cgcactgggc atcacatatt caaaaacact tgatgtcatt gcggttagca tttatatggc 1702561 ggcgatttat cttcatgcat ttttggtgtt cacggcagct tttcgcacca agacggggac 1702621 atttcttatt cggctttctt ccgctgtttt aatgataacg attgctttct cgatgattta 1702681 ttcatttggt gtctttcggc aagaagttac attgaccatc aatcagatga tttggattca 1702741 cggttttgtc aacgcgtttg gtgttatctt gcccgctctc atagggtgga gaatagagga 1702801 tgcgaaacct tttgatgcag acagtgtaaa gacattcagc cgtatctacg gaaaaagaaa 1702861 gattggagaa gaatttttag ctaacattca agctgaaaat aacgctcggt acagcggact 1702921 tgtggatgat atgggcagcc tgcgttcaaa agatttttca ccagaaaaac tggcgccgct 1702981 cattctttcg ttttatgaac aaaccatcga atacaatatt aaagcaaaag taacatggag 1703041 cacgtggttt cggccgcttg caattattta cgaatggttc agcagaagaa tcggccaaat 1703101 acatctttcg acgaaccctg actggtatag gatgtacagc aagataaaag gtgttcattc 1703161 gaaaaaagac ggaagggaaa gagtacgtgc ctggattaga acaaatgaaa aaaacgaaac 1703221 catttttacc gctctttatt cagtgtatcg ttcaaatgga gaggggtata tgaatatttc 1703281 tttaccgctt ccattcagca gcatgacagg tattttaaaa ccatatcatc atcaggagaa 1703341 gctggtttta acaagcaggc ggagaaaaag cagagcgggg gatgagggga tttatctgca 1703401 aacaagagcg ggaacttgtc cgcttccttt atctgaaacc tttctgatag aagctgtaca 1703461 tgacaacaaa ttaaccgctg ttcatcatat gtggctgttt ggaataaaat ttctaactgt 1703521 tcattacagc attacacata ttaaccagcc tattgaaaga acctaacaca aagaagaagc 1703581 ttcgtctgcc agttgtaatg agatgaactg ttttaaaatt ctgcaccgca tcaagacagg 1703641 aaaggaaggg tttatggtgt tttatatcag tttatttctg attctttggc tggctgctgg 1703701 gtttgcagtg ggaatgaaac aagtgtatgt cgatcagctg tttgataaag ctgtgatcga 1703761 aagactggaa aaagaagcga atgatcatgg acatgctgac cggatgatca aacagcgcgt 1703821 cctttatatt gcagcagtga cagtaagcgg gtttatttct gtttattatg aaatgaaaac 1703881 aatcccgcaa aggcgaaaca taagaaaaat tgaaaaaaac atcatgaaat taaatcaagc 1703941 aaaaaaacga agaatgaaga gaaaataaaa agtgcacagg ccaaagggca ggtgcatttt 1704001 tgttttgtat ggaaaatggg ggaggtggtg ccagcttact tttcataaat tcaaaaatga 1704061 gaagaacagc gcccgggcta atggtatata atattgtgaa tttaacaaaa atttaacaag 1704121 gaggacgaga gaattcgtgc taaagcctca aagagaccta cattctgttg atttggactt 1704181 agaggcggag tagatgaaac cggccaaagt atccctgctc cgccgtttgc tccattcctt 1704241 gaagcatgtt gattgtaaca tagccaaacg ttttccatca actattaaaa ttgtaaaatt 1704301 attgatgatt tttatggtgt ttactccgat ttcttcaatt tatgctgaag atgtatatca 1704361 gaattttgag gaattaaaaa acaatgaaga tccttctgat tatggcgttg ttacgaaaga 1704421 aaccggaagc cctgttcttg ttttagctat tcacggagga ggtattgaag gcgggacaag 1704481 tgaagtagcg agagagctca gcaaagagta ctcgatgtat ttatttgaag gcttaaaatc 1704541 ggcaggaaac tcagtcctgc acattacgag cacacacttt gatgaacctc gggcccttaa 1704601 aatgacggga aatcatgaat atgtcatttc attacacggg tacgcagaag aagatcagca 1704661 gatcgaagtc ggcggtacag atcgcgtaag agcggcagat ttagttgaga aattgcagca 1704721 tgccggtttt cctgctgtat tgctcaatat ggaccatccg catgcgggcg ttagtccgaa 1704781 taacattgca aataaatcaa aaacaggttt aagtattcag atagaaatga gcacagggtt 1704841 tcgaaagtct ttgttcggca tcttttcttt aaaaagcaga gctgttactc aaaatgagag 1704901 gttttatgag tttacagaag tgatgttccg ttttctcaaa aatagctact gaaaaatagg 1704961 aggcgataag acagcctcct attccttatg cttctctttc gtttcgggaa acagctcgtc 1705021 cgcggcttcc gtttgatact gcaacgtgtt atctctcgct gacagttcat ttcggaaatt 1705081 ttcatcaagc acatttttca gtaaataccg atgaaaaaag tattcaaaaa cagtaagaca 1705141 ggcagcggaa aggagagccg ctccaaatgg tgagaaatcg tttcttgttt gggttaaaac 1705201 aaatacccaa agaataacga atgaaaggcc aaagtcagcc aatgaagctg taatattgtt 1705261 tgttctgggt aagacgagca tgtcaccaga aagataggaa acaaaaccta agaaaagtgc 1705321 aataaacatc acacttaaaa aggatgcgtg atagactctg tccaaaatca catataaaag 1705381 ggcgagagtg aaagcaatct ttgaagcaag cgcaatgata tgtttcattt gaccacctaa 1705441 attgttattt tttgaagaaa attcttgggc gtaaacaaat gataaataat gcaattcaaa 1705501 accattcata atggtcatgt tactatttta aacagtccgt ttttgtttac actggtattt 1705561 ttttcagctg tatgaaactt tcttatgaaa aaagtcgtat atgtggatga tcagctttca 1705621 aggggggaat gatttgtgga gataaaagga atcaatcact tgctattttc agtttcgcat 1705681 ttggatacat cgattgattt ttatcaaaaa gtgtttggtg caaagctttt ggtaaaggga 1705741 agaacaactg catattttga tatgaacggc atctggctag cgcttaatga agaaccagac 1705801 atcccgagaa atgacattaa gctttcttat acccatattg cttttacaat tgaagatcat 1705861 gaatttgagg agatgtcagc taaattaaaa agacttcatg tcaatattct gcctggcaga 1705921 gaacgagatg aacgcgatcg aaaatcaatt tattttaccg accctgacgg ccacaaattt 1705981 gaatttcata ccggaaccct tcaagacagg cttcgatatt acaaacaaga aaaaacgcat 1706041 atgcactttt atgatgaaac ggccttttga tagcacaacc atatttcata taaggttaaa 1706101 tttaaagaag ggtgttggtg gagactttat gtttggggaa ggtttctacc cgacttgttc 1706161 aacgatgcca tatcttttga actgcacaag tgattgggtg aaggtgaaat tgaaatacac 1706221 attacattac attttatatg aagaaagcga gctgttttat caaatgttga actaattaaa 1706281 ctatgtacta aattttcagt atatttcaat tgctttgccc cttaataaat ataaaaccgc 1706341 atccttccac gacctaaaaa atgaaacgtt tttaagaaga tggcgtctaa tattctaaat 1706401 gttcatattt tgataaaagt ttcctaaagg aaagaaaatt tcttgacttc aacaatcttt 1706461 tggtggataa ttatggtgta aacatgatgt tctttttcct cctattcggg ctcgcaccca 1706521 aaagtcaggg cgagcctgct ttttttgaac aacaaacccc ctctccgtaa aggaagaggg 1706581 ggttatttta tgcatctgat agatcaatag attaatggac ggttctgaac acgccaatca 1706641 ctttccctag aatgctgaca ttctgcaaaa tgataggttc catcgttggg ttctcaggct 1706701 gcaagcgaat gtgggtatcc tctttataga atcgttttac agttgcttca tcatcttctg 1706761 tcatcgcaac tacaatttcc ccattgttcg ctgtgttttg ctgtttaacg atgacatagt 1706821 ccttatcgag aataccagca tctatcatac tgtctcccat aatctccagc ataaatacat 1706881 gctcgtctgg aggaaccatg cggtcaggga gcggaaaata ttcttcaata ttttctactg 1706941 ctgtaatagg agatcccgcc gtgactttcc cgatgaccgg tacattaacg acctggcttt 1707001 gcggaatgtc tacttcttca tcaagaattt ctattgctct tggttttgtc ggatctcgtc 1707061 tgatcagccc ttttgtttcc aaacgggcca aatggccgtg gacagtagaa ctggacgcaa 1707121 gcccgacagc ctctccgatc tctctcacgg aaggcggata tccttttgat ttaacctctg 1707181 ctttaataaa acggaggata tcaagttgcc tttttgatag cttcgtcatt tttcgcacct 1707241 caaaacgtcg attttaagaa gattatagca tgattttcct tacagtacaa acataggttc 1707301 gaaaaaacaa ttgacagaaa cgtttgttcg tatatactga aattataaaa atgcgaacaa 1707361 acattcctgt tggaggttat gatcatgagt aaagaatcta ttatttttgt cggtctgttt 1707421 acagtgattt tgagcgcggt tatccttatg ctgtcatata caagcagcgg ccaagagctt 1707481 aatcagtatg ttaaaataga agtccagcaa ggcgacacac tctggtcaat tgctgatcag 1707541 gtagccgata caaaaaagat aaacaaaaat gattttattg aatgggtagc tgataaaaat 1707601 caacttcaaa cctctgatat ccagccgggt gatgagttag tgatcccatt gaaaaagaag 1707661 catcaggatg catatgaatt agcaactgta agatagagag gaaagagaga taaaatgaaa 1707721 gcactcattt atgcccgtgt aagcacaaat aaagaacagc aggaaacgtc attaaagcgg 1707781 caggaggagg agcttacggc cattgcagcg gagaacggca tggaagtggt caaagtgatt 1707841 tcagaaaaag ccagcggata tgaaatggat cgggatggtg tatttgagct gctcgatgag 1707901 attaagaacg ctgatattga tgtcattttg gttcaggatg agacaaggct cggacgggga 1707961 aacgcaaaaa tcgcactgct tcattgtatt tatagagaag gtgtgaaagt ctatacaacg 1708021 gctcatagag gtgaactgga gttatcggag gctgactcaa tggtcttgga aatcgtcagc 1708081 attgtggaag agtatcagcg aaagattcac aacatgaaaa tcagacgggg aatgaaacgt 1708141 gcagtaaaaa acggttttaa accgcaaaaa aacttaaaaa accaacatgg gaacagtgga 1708201 aaagaaaaaa tagaggtgcc aatctcagag atcgtccgcc tgagagcgaa taaactgacg 1708261 tttgctgaaa tcgcggctac cctaagaggg tttggctatg atgtctctaa agcaaccgtt 1708321 caccggcgtt ttcaggaata catagagaat gaagagactg cagagtgaat cagttgtaaa 1708381 actttttttg atctagtact atatagacaa aatgcaataa aggagtttaa catgatttca 1708441 aacgcgaaaa ttgccagaat taatgaactt gctgccaaag ctaaagctgg cgttattaca 1708501 gaagaagaaa aagccgaaca gcaaaagctc cgtcaagagt acttgaaagg ttttcgttct 1708561 tctatgaaga acacgttaaa aagtgtgaaa atcattgacc cagaaggcaa tgatgttaca 1708621 ccagaaaagc taaaaagaga acaaagaaat aacaaacttc actaatataa gaggaatacg 1708681 gcaatatcgt attcctcttt tgcatatact ataatcaaaa ctcttatgtg acaaaattca 1708741 acaagtttct ctcaaattta agctgaaaca gttgagaaaa agtcgtcaga catttatgat 1708801 gtaagggtac aacacataag gaaggggatt tttatggata caattgaaaa gaaatcagtt 1708861 gctaccattc gcacactgtc aatagacgct attgaaaaag caaattctgg tcacccaggg 1708921 atgccgatgg gagccgctcc aatggcatac acgctgtgga caaaatttat gaacgtaagt 1708981 ccggcaaacc ctggctggtt taaccgtgac cgttttgttt tatctgctgg acacgggtca 1709041 gcactattat acagcatgct tcatttaagc gggtttgatc ttagtattga agatcttaag 1709101 ggattccgcc agtggggcag caaaacacca ggacatccgg aattcggaca tactgccggt 1709161 gttgatgcta caacaggtcc gcttggccaa ggaattgcca tggcagtcgg tatggcaatt 1709221 gctgaacgcc atttagcgga aacatacaac cgcgattcat ttaacgtagt cgatcattat 1709281 acatacagta tttgcggtga tggtgattta atggaaggta tttcttctga agccgcttca 1709341 ctcgcaggcc atcttcagct tggccgtctg atcgtactat acgattctaa tgacatctct 1709401 cttgatggag acctcgaccg ttcattctct gaaaacgtga aacagcgttt tgaagcaatg 1709461 aattgggaag ttctttatgt tgaggatgga aacaatattg aagaattaac agcggctatc 1709521 gaaaaagcac gccaaaatga aaagaaacct acattaattg aagtgaaaac gacaatcgga 1709581 ttcggttcac ctaaccgtgc cggtacatcc ggtgttcacg gtgcgccgct tggtaaagaa 1709641 gaaagcaaat taacaaaaga agcttacgcg tggacatatg aagaagactt ctacgttccg 1709701 tcagaagttt atgagcattt cgctgtagct gttaaagaat caggtgagaa aaaagaacaa 1709761 gaatggaatg ctcaattcgc taaatataaa gaagtttatc ctgaacttgc tgaacagctt 1709821 gaactggcaa tcaaaggaga gcttccgaag gactgggatc aagaggttcc tgtgtatgaa 1709881 aaaggaagca gtttggcatc ccgtgcatct tccggtgaag ttctcaacgg acttgcgaaa 1709941 aaaattcctt tctttgtcgg aggttctgct gacctagcgg gatcgaacaa aacgactatt 1710001 aaaaatgccg gtgattttac agcggttgat tactcaggca aaaacttctg gtttggtgta 1710061 cgtgaatttg cgatgggtgc ggccttaaac ggtatggcgc ttcatggcgg tcttcgtgta 1710121 ttcggcggaa ctttctttgt cttctctgat tacctgcgtc ctgcgattcg ccttgcagcg 1710181 ttaatgggcc ttcctgtgac atatgtcttc acacatgaca gtattgcggt tggtgaagac 1710241 ggtccgacgc acgagcctgt tgaacagctt gcttcactcc gtgcgatgcc taacctttct 1710301 ttgatccgtc cagcagacgg caatgagaca gcagcagcat ggaagcttgc agtgcaaagc 1710361 actgaccacc caacagcgct agtgcttaca cgtcaaaacc ttcctaccat cgatcaaaca 1710421 tctgaagaag cattggcagg agtagaaaaa ggtgcatatg tcgtttctaa atctaaaaac 1710481 gaaacacctg acgctcttct catcgcttcc ggatcagagg taggtcttgc aattgaagcg 1710541 caggctgaat tggcaaaaga aaatatcgat gtttctgttg tcagcatgcc ttcaatggac 1710601 cgttttgaga aacaatctga tgaatacaaa aacgaagtcc ttcctgcaga tgtgaaaaaa 1710661 cgtcttgcaa ttgaaatggg ctcatcattt ggatggggca aatacacggg gcttgaaggt 1710721 gacgttctcg gcatagaccg attcggtgca tctgctcctg gtgaaaccat cattaacgaa 1710781 tacggcttct cagttccgaa cgtagtgaat cgagttaagg cattaatcaa taagtaagct 1710841 tttgaaagag gatgagtcaa atcatcctct ttttcttgtt tatccgacaa aaatagtatt 1710901 ggctgtttaa cagtaataga caattctttc ttttcttctt ttgtataata gagagcaaat 1710961 gaaatgctgc tggaaaaggg gatgaaaaga tggaacgtca ctactatacg tacctgatca 1711021 aagaggaatt tgccaatcac tatttcggcc gggaatcggt tatgtttgag ctgtttcaag 1711081 actatcattg gacaagcctt gaaaagcagc agtatgaaat gacagagaaa cagattcaat 1711141 atattacaca accaatcccg attttacata tgcatcagcg gttaaaaatg aatttaaaca 1711201 agacggatta caggcagctg gattatattt atagaatagc tttgccgaaa gcaaaaggcc 1711261 acgcgacgtt tatgatgaag gagcacatga tagaaattgt ggcttcggga gattacgagg 1711321 cagaaacgat attctttgaa gtgttaagaa aagtaagccc ttgcttttta gcaatggatt 1711381 tcaattcgaa gcgttacgga tggctaaatc cggtgaaaga aagaaatttt gtctaaaacc 1711441 gaagaaaaag agatgtaaat gttgtataat agcttttggt ttagtacact ttaaactaga 1711501 caacatgaag gaggaaataa aatgacttta tgggttggca tcctagtggg cgttgttgca 1711561 ttgctcatag gtgttgcact cgggtttttt attgctcgta aatatatgat gagctacctg 1711621 aaaaagaatc cgcctattaa tgaacaaatg ttacgcatga tgatgatgca aatgggaatg 1711681 aaaccttctc aaaagaaaat caatcaaatg atgaaagcca tgaataatca aacgaaataa 1711741 tacgtaaaga ttatgatata gagaaacatg gttataaaat aaaaaaccct tatacgggtt 1711801 ttttattttg caatcattca tcacccgcta ctgctcgaag gcgctgcttt tgatattgta 1711861 tgagaagatg gtcaagctcc tgactgagct ctatcgtaat atgagatgtc attccgttcg 1711921 ccatgacaat ttgcagcagc tctgctcttt ttttttcaat ttcttttaat agatgctctc 1711981 taatcacagg gatgtatcct ttcatacatt agatcttcaa agtgaatgtt tatattatat 1712041 ccatatttat actaattttc aaatgagaag gagtataatg tctcaatgtc aaattaaatt 1712101 atataagttt tttctgaaaa tagaaatcct tcaagtgaaa gtgttaaaaa aatgaaatga 1712161 ttttgtcata acttgaagga atgtcaaatc atgaagggat gatgacatgg gagacgtgaa 1712221 ttattttttg acattcggag cggggttttt atcctttatt tcgccttgct gcctgccgct 1712281 ttacccagct tttttgtcat atattacagg ggtcagcatg gacgatgtaa aaactgaaaa 1712341 gctgctgctg cagaaaagaa gcttgtttca tactttgtgt tttttgcttg gcttttcagt 1712401 catttttatt gctttaggct atggaacatc ttttattggc agcctgttta gggattatca 1712461 cgatgcgatt cggcaaattg gcgcgttgct tattattttg ttcggtttca ttacactcgg 1712521 tgtgttccgg cctgaggcta tgatgaaaga gcggagaatc cattttaagc ataaaccaag 1712581 cgggttttta gggtcggtct taatcggaat ggcatttgca gctggatgga caccatgtac 1712641 cggtccgata ttagctgctg ttatcacact tgcaggcacc aatccgggct cagcggtgcc 1712701 atacatgatg ttatatgtac tcggttttgc ggtaccgttt cttttattgt ctttttttat 1712761 cacaaagctg aagtggataa ggaagaacca gcttttcatt atgaaagctg gtggcgtttt 1712821 gatgattgtg attggtgtgc tgttattctt taattggatg agcctgatca ttattttgct 1712881 gtcagatctt tttggaggct ttactggttt ttgacggtaa attactttcg tactactact 1712941 aatccttttg tttttggtac aataagacta ttatctgtgg aaatcgattg ttggagggga 1713001 atatgacaag agttttagtt gtagacgacg ccaagttcat gagagtgaaa atcagagaga 1713061 tcttggaaga ggcaaattac ataatcgcag gcgaagcggc ggacggtgaa caagcagctg 1713121 acctgtataa aaaactgcgc ccggaccttg tgacaatgga tattacaatg ccggtgaaaa 1713181 acggcataaa agcgcttcgt gatatcttaa cctttgatcc taaagcgaag gtcatcatgt 1713241 gcaccgccat gcgccagcaa agaattgtaa cggaagcaat tgagctgggg gcaaaggatt 1713301 ttattgttaa gccgtttgag gaaacaaaag tgctggaagc tgtaagccgc gttatgggac 1713361 attaaagtca tttcttttca aaatggtttt ttttattgtt ttggagtata gtatatagta 1713421 tcaacactcc gagaaacaaa ggaatgataa gtatgatgat tatagtttca tcaattattg 1713481 ctgtgttaat ggctgtagct gtgatggtgg tcagaataaa gtcctctgac aagcctgttt 1713541 caccaaaaaa aatcattctt ccgccgattt ttatgagtac gggagcgtta atgtttttat 1713601 ttccggtatt ttgggtaact ggagcagagt ttttggaagc attcacttta ggtgtgattt 1713661 tctctatttt tctaatcaaa acttctaagt tcgaaattaa aaataatgaa atttacatga 1713721 aacgctctaa agcatttgtt tttatattag tcggtctttt ggtgatcaga atcgtgatga 1713781 aatcgatctt gagcacatca attgattatg gtgcactgag cggaatgttt tggattctgg 1713841 ctttcggtat gattgtgcct tggagaatcg ccatgtattt atcatatcga aaacttcata 1713901 acgagctgca gtcatctaat attcaaatga attaaaaaac ctttcctctt gtcaggaaag 1713961 gttttttatt tgagaagggt ctgataaggt tccaaatcga tttttttgtc ccgcagatgc 1714021 ctttttaaga aggtatggtc tcttttagga gttgcgagaa tatagccttt gatcataagt 1714081 tgctgatcaa tctttgctac cttttctttt aatgcaagct caccgatttt gcctgcgatt 1714141 ttagcttttg ctgcatctct gaacagctct ggcacgggcg cagtcaattc atctagaaac 1714201 tgtttgtttt catcgttcca taaatgtctg ctgttttcaa tatagtaatc ctgccaatca 1714261 agctctgatc tgccgtcctc ttttggtaaa cgctttaaaa actttcgaaa catgaaaaaa 1714321 ccgccgattg ataataagac taccatcatg attacccaaa acagaataaa ccataaaaac 1714381 catccttcca gcatcaatca ttccccctta ttctaaccat attgtatacg aagagagatt 1714441 agaagaacac agtaaaaaaa gaatagaaaa aagtgataga cgtctagtca aaagagatag 1714501 tagatcatat tctattgtat agtgaatctg ctatttggcc atgggagagt cactagaggg 1714561 tatttgacga taaatggacg gaaaaaaagt cactttcata ataggggatg aaagtgactt 1714621 tttatgttta gctgagagga aattgaagag aaaaagaaga gccatcttct gtttctttat 1714681 tgacggcgac tgtgagtatt tgattttcgc attcgacttg aatgtttttg tcattaaaat 1714741 aaaaaggaag catcatttgt ttttcaaaag tctgtcctga cgatttgaca gttaagatga 1714801 actcgcatcc agaaagggta actgttactt gtgtaggctg taaaaaagtc agatccgctt 1714861 ctataatata ctgctgactt gtttcatata aatcaatagg caatgtttcg tcgtaccagg 1714921 cgaaggggtc ttcaaaaaat tgccgaagcc attcatccat actatcgaaa tcattcgcat 1714981 cgttgcgttt tgaatggttc atggaagcat tcctccacat atcaaccttg ctttacatca 1715041 tatgcggtgg attataaatg ggtgaacgca taaaaaaaca gacactaagg tctgcttttc 1715101 ttacatatca tggcttgagt tgtgcttttg tcttgtatgg tttcggtttt ttactttttt 1715161 gcttccgctt agaggctcgg gttggccggg attgtgtcct ttaggggcgt ttttatgcat 1715221 atctttactt gtattcttat tggtcataaa atgagaacct ccttaaaaga gttcggtgtt 1715281 attgattggt ttttcttttt ttgttatttt ggcgttctgc ttcagtcagt acaagctggt 1715341 cgttttcaat atagccggcg cctttgcctt ggctttttgc gtcattcatt ccgttaatga 1715401 cgtgattcgc ttttcttttg accatcatta tcacctcaat cataatatgg cttcttttat 1715461 tgtgttatat gagagagcgt aaacagtaaa aattaccggt acatttttct cataagtcga 1715521 acttattgta tttaataaaa acattgatat ttacttatgt atgattttgt tttaatatga 1715581 aattgtgaga aaattgtgat ggaatgtaat gttcatctga gaatgatctg atctgaaggg 1715641 ggattttgga gaatggcaaa cgagcaaaaa actgcagcaa aagacgtttt ccaagcgaga 1715701 aaaacgttta ctacaaatgg gaaaacatat cattactact ctttaaaagc gttagaagat 1715761 tcaggtatag gaaaggtttc gaagcttcct tattccatca aagttctttt agaatcagta 1715821 ttgcgtcaag ttgacggctt cgttatcaaa aaagaacacg tggaaaattt ggcaaaatgg 1715881 ggaactgccg aattaaagga tatcgacgtt ccgttcaaac cgtctcgtgt tattttacaa 1715941 gacttcacag gggttccggc agtagtagat ctggcttcac tgcgtaaagc aatggcagct 1716001 gtcggcggag atcctgataa aatcaaccct gaaattcctg ttgatctcgt tatcgatcac 1716061 tctgtacagg tagataaagc gggtacagaa gatgcattag cagtaaatat ggacttggaa 1716121 ttcgaaagaa atgcagagcg ctacaaattt ttaagctggg caaagaaagc gtttaacaat 1716181 tatcaggcag taccgcctgc aacaggtatt gtgcaccagg tcaaccttga gttcttggca 1716241 agtgttgtcc atgccattga agaagacggc gagcttgtaa cgtatcctga tacgcttgtc 1716301 ggaacagact cacacacaac aatgattaac ggtatcggtg ttctcggctg gggtgtcggt 1716361 ggaattgaag ctgaagcggg aatgcttgga cagccttctt acttcccagt tccagaggta 1716421 atcggcgcga aacttgtcgg caagcttcca aacggaacaa cagctactga cttggcgtta 1716481 aaagtaacac aagtgctgcg tgaaaaaggc gttgtcggta aatttgttga attcttcgga 1716541 ccgggaattg ctgaactgcc gcttgcagat cgcgcaacaa ttgcgaatat ggctccggaa 1716601 tacggtgcta catgcggatt cttcccagta gatgaagaag cgcttaacta cctgcgcctg 1716661 actggccgtg atcctgaaca tattgatgtt gttgaagcat actgcagaag caatggcttg 1716721 ttctacactc cagatgcgga agaccctcaa tttactgatg tggttgaaat tgacctgtct 1716781 caaattgaag caaacttatc gggtccaaag cgtcctcagg atttgatccc gctatctgct 1716841 atgcaggaaa cgtttaaaaa gcaattagtc agccctgcag gtaaccaagg attcggttta 1716901 aatgctgagg aagaaaataa agaaattaag tttaaactcc ttaacggcga agaaacagtt 1716961 atgaaaacgg gtgcgatcgc cattgctgcg attacaagct gtacaaatac atcaaaccca 1717021 tacgtgctga tcggcgccgg actggtagcg aaaaaagcgg ttgagttagg gcttaaggtg 1717081 cctaattacg tgaaaacgtc acttgcaccg ggttctaaag ttgttacagg atatcttgtg 1717141 aattcaggcc ttcttccata catgaaagag cttggcttta acctcgttgg gtacggctgt 1717201 acaacatgta tcgggaactc aggtccgctt tcaccggaaa tcgaagaagc ggttgcgaaa 1717261 aatgatcttc tgattacgtc tgtcctttcc ggaaaccgta actttgaagg acgtattcac 1717321 ccgcttgtta aaggcaacta tcttgcttca ccgccgcttg ttgtggcata tgcgctggct 1717381 ggaacggtaa acattaactt aaaaaccgat ccaatcggtg tgggcaagga tggtcaaaac 1717441 gtatacttta atgatatttg gccgtcaatg gacgaaatca atgcacttgt taagcaaact 1717501 gttacgccag agctattccg caaagagtat gaaacagtat ttgatgacaa caagcgctgg 1717561 aacgaaattg aaacaacaga tgaagcttta tataaatggg ataacgattc aacttacatc 1717621 caaaacccac cattctttga agagatgtct gttgagccag gcaaggttga gccattaaaa 1717681 ggactgcgtg ttgtcggtaa attcggcgat tcagtcacaa ctgaccatat ttctcctgcg 1717741 ggggcaatcg gaaaagatac gcctgccgga aagtatttgc aagaaaaagg tgtttcacct 1717801 cgtgacttta actcctacgg ctcccgccgt ggaaaccatg aagtcatgat gagaggaaca 1717861 tttgccaaca ttcgcatcaa aaaccaaatc gcaccgggta cagaaggcgg atttacgacg 1717921 tactggccga ctggtgaagt aacatccatc tatgatgcat gcatgaaata caaagaagat 1717981 aaaaccggtc ttgtcgtatt agcaggaaaa gactatggta tgggatcttc acgtgactgg 1718041 gctgcaaaag gaacaaacct tctcggcatc agaacggtca ttgcagagag cttcgaaaga 1718101 attcacagaa gcaatcttgt attcatgggt gtgctgccgc ttcagtttaa acaaggtgaa 1718161 aatgcggata cactcggctt aacgggtaaa gaagtcatcg aggtagatgt tgatgaaaca 1718221 gttcgtcctc gtgaccttgt gactgtaaga gcaatcaatg aagacggcaa tgtaacaact 1718281 tttgaagcag tcgtccgctt tgatagtgaa gttgaaattg attactaccg ccatggcggc 1718341 atccttcaaa tggtgcttcg tgaaaaaatg aagcagtcct gatgaatcaa taggaagaga 1718401 aggcatttcg ctttctcttc tttttatgac acaatgtgct gcggaggtgg catatgctga 1718461 aaaaatggct cgcagggatc ctgcttatca tgctagtcgg ttatacggga tggaatttat 1718521 atcaaacata cagcaaaaaa gaagtcggaa ttcaagaggg gcaacaagca cctgattttt 1718581 ctttgaaaac gctatcagga gagaaaagct ctttacagga tgcaaaaggc aaaaaagtgc 1718641 tgctcaattt ttgggcaact tggtgtaagc cgtgccgtca ggaaatgcct gcgatggaaa 1718701 agctgcaaaa agagtacgcc gacaaacttg cggttgttgc ggtaaatttc acttcagctg 1718761 agaaaagtga gaaacaggtc cgagcgtttg ctgatactta tgacttaacg ttccccattc 1718821 tgattgataa aaaagggatc aatgctgact ataacgtgat gtcatatcca acgacatata 1718881 tcttagatga aaaaggtgtt atccaagaca tacatgttgg caccatgaca aaaaaagaaa 1718941 tggaacaaaa actggatctt gattagattc agtttttttt atactcaaat atgcttacaa 1719001 gttttcagaa ttggaaaaaa taaaagaata tgcggaggtg agaagcgtga agaagatgag 1719061 aaaacgttct tttcatgagc tcgtcatgga aaacaaaaaa gagctgatga ccaatacaga 1719121 gtatttaaat cagcttgagg aaaagcttga acagcgattt aagcaaaaat aacctttaat 1719181 ttgtattcat gtttacccct ccttttgaga aacctatctg ttgaggaggg ataaacatgg 1719241 gaaacaacaa gaaaaacggt cagcctcaat atgctccaag ccacttgggt acaaagcctg 1719301 taaaatataa agccaataaa ggggaaaaaa tgcatgatac ttcaggacag cggccgatta 1719361 tcatgcagac aaaaggcgag tagcgaaaat tcgagtttat ttctaggagg tacatccgaa 1719421 tgacaaagaa ccaaaatcaa tatcagcagc ctaatcctga tgatcgttct gacaatgtgg 1719481 aaaaattgca ggatatggtt caaaatacaa ttgaaaatat agaagaagca gaagcatcaa 1719541 tggagtttgc ttcaggagaa gataaacagc gtatcaaaga aaaaaatgca aggcgcgaac 1719601 agagcattga agcgtttcgt aatgaaatac aggacgaatc tgcagcgaga caaaacggat 1719661 accgttctta aaaaaccagg gaaacctggt ttttttcttt ctgatttgat tatggtaaaa 1719721 tggggctaaa ttgacgttaa gggagcagag taatcttgca tgtatcaaaa aaagaaatag 1719781 aagtgcgtta tgcagaaaca gatcaaatgg ggattgtcta tcacgcaaat tatcttgtgt 1719841 ggatggaggt cggcagaacg gccttgatta aggacttagg ctttttatat agtgatatgg 1719901 aaaaaaaagg cgttctgtcc ccagtcgttg atatcaatat ttcctataaa aagccgcttc 1719961 attacggaga aaccgcggtt gtacatacat ggatagagga ctataacgga tttaaaaccg 1720021 tctatggtta ccacatttat aatccggccg gtgagctttc catcaaagcc acctcatctc 1720081 atatttgtgt ggataaagaa agctttaagc caattcaatt ccgcaaagct tttcctgatt 1720141 ggcacacagc atatgaaaag gccaaaaaat agggaagtga acgggatatg gcgtttggtg 1720201 tgaaacggga ggaacttaac cggtggaaac aagcagtgaa aagaggagaa atcgcatttt 1720261 taacacatta ctggctggat gaccgatttc cagaagcaaa gaccgtgaca aaagccggct 1720321 gtgcagacat tgataagctg gttcagtggg gagcggcgta cgggttaaaa aaagaatgga 1720381 tccataagaa aagtgaattt ccccactttg atctgctggg ggaaacacaa aaatatattt 1720441 tggaacaaga aaacctaacc gatcatctta tacgatttca tttgtaaaaa aagaacgcac 1720501 atgaagtgcg ttctttttta ttggtattca aaaaccggtt catcagcgtc ttctgaatag 1720561 ctgacgagaa ggtcgtggtt atcaaagtac cataaatcac tttcttcaat aaagaaggta 1720621 atgccatcag cttctgcagt gactccagcc tcttgtgggg catctttcgc tacaccgaga 1720681 gaaaaaccct tttgaacgtt gctgcagcct ccatagcgga cgaaaaagcg aacctggtct 1720741 ccgctttcca aatcgagttc ttctttatac cagttcaatg cgtcttcgtt aattgtcata 1720801 ttcataacag aacacccctt tgttcttcat ttgaattttc tctattataa acgtattagg 1720861 ctattctgtg tcaaaagaga agttttttaa gcttataacc attttacttt aggttctgtt 1720921 ttattgataa ttcgtttaat gttcgctcgg tgtctgtata tcacaaaaat agtgagcagg 1720981 gtaacgacaa tcaataaata cgtatcatgg acaaagaaac tatatataac agtatagatc 1721041 cctgttaaca tcgatgagag agaaacaaat ttagtcaagt ataaaaagat gaagaatacc 1721101 gcaaccatcg tgataaataa caggggtgcg taaaatagca aaacgcctcc tgatgtcgcc 1721161 acggctttac cgcctttaaa tttggcgaag atgggaaaca cgtggcctaa aaccgcaaag 1721221 actcctgcaa gaagcgggtg aatatcaaca tgcatgagaa aaggcaatgc agttgccagt 1721281 gtccctttca aaatatctcc ggctatgacg accgaaccag cttttacacc caatgtacgg 1721341 aatgcattgg tagcgcctaa gttgccgctt ccgtgctccc gaatatcaat tcctttggca 1721401 agcttgccca caattaagcc agatggaatg ctgcctatca agtaggccaa aataatcaat 1721461 aaagcaatta acatctacat ttctcctttt tcaaattccc ttctttttat tttaacatga 1721521 gatgtcatga tctgatgata agtttttttg taaagtttgc ttacaaatca aatcaaacat 1721581 gcatcatatt ttgatttctc ctgttttgat cgtgtaaaat aagtgaaaaa ggagtgacac 1721641 acgatgcaaa acccttctaa agcggaaatt aaagagattc ttcaaagaag caaacgtata 1721701 gcggtagtag ggctttcaga ccgtccggat agaacgtcac atatggtttc aaaagcaatg 1721761 caggacgcgg gttatgaaat tatccctgtg aaccctacaa ttgatgaggc gctaggtgtc 1721821 aaagccgttt catctttaaa agagatagac ggtccgattg acatcgtaaa tgtattccgg 1721881 cgctcagaac agcttcctgg agtggcggaa gagtttttag agacagatgc gccagtattt 1721941 tgggcacagc aagggctagt taatgaggaa gcataccaga tgctaaaaga aaaaggcaga 1722001 acggttatca tggatctgtg cataaaagtg gcacacgctg taacaaaata ggtgcagaac 1722061 tgcaaaaatc cttgtaaatt caaggatttt tgctttttaa ttttaagata ttgtttgcgt 1722121 attacggtga aacagataca ataaagcttg aacagctttt tttgaatacc ttgtccagct 1722181 gggtttcggc cgttcgattt gcgaaggtct gctgctttat atataataaa caaacatacg 1722241 ttctcatagt gtaaaaacag cactagccga tgttttgaga agaactgatt cgttagctct 1722301 atgttgcgat tgcaaacata ttggttataa tgaggagtcc aaggcagtac tggctcgagg 1722361 cgaggtttat aaaaaatatc ttatatacaa atgatgtgta acactgaaaa gagaaagaca 1722421 atgttagttt ttgaaagggg tttgtacgtt tggctagaaa acagcaattt gattacaacg 1722481 aagatgccat acaggtgctc gaaggccttg aggctgtcag gaaaaggccg ggtatgtata 1722541 ttggctctac tgacgcgcgg ggtttgcacc acttggttta tgaaattgta gataactctg 1722601 tcgacgaggt gcttgccggc catggagatc acataatcgt caaaatacat aaagacaata 1722661 gtatttctgt acaggataga ggccgcggca tgccgaccgg aatgcataag ctcggcaaac 1722721 caacccctga agtgatttta acggtgcttc atgccggagg gaaattcggc caaggcggct 1722781 ataagacaag cggcgggctc cacggagttg gtgcatcagt cgtgaatgct ttatctgaat 1722841 ggctgacggt taccattgag cgggacggtt ttgtctatca gcagcgattt gaaaatggag 1722901 gaaaaccggt tacatctctc gaaaagatcg gcaaaacaaa aaagacggga actcttacac 1722961 actttaagcc agatccaacg atgttcagca caaccactta taattttgaa acgctctctg 1723021 agcgcttaag agagtctgcg tttttgttaa aaggactgaa aattgagctg attgatgaac 1723081 gcaatgacca gcgtgaggtc ttttattatg aaaacggcat agaagcgttt gttgcttact 1723141 taaatgaaga aaaagacgtc ttgtctgaag tggtctcgtt tgagggtgag catcattcta 1723201 tagaagtgga ctttgcgttc cagtttaacg atggttattc tgaaaatatt ttgtcgtttg 1723261 tcaacaatgt cagaacaaaa gacggcggga cgcatgagtc aggtgcaaaa actgcgatga 1723321 cgcgtgcttt taatgaatat gcgcgaaaag tggctttgct gaaagaaaag gataagaacc 1723381 ttgaaggcac cgatataagg gaagggcttt cagccattat ttctgtccgc attcctgagg 1723441 agcttcttca atttgaggga caaacaaaag gaaagctcgg taccagtgaa gcaagatcag 1723501 cggtggatgc gattgtttca gagcagcttg cttacttttt agaggaaaat cgggacaccg 1723561 caacgcttct tgtcaaaaaa gcaatcaagg cgagccaggc gcgcgaagcg gcacgcaaag 1723621 cccgtgaaga agcaagaagc ggcaaaaaac gaaaaaaatc agaagcgact ttaagcggaa 1723681 agctgacgcc tgcgggttca agaaacccgg caaaaaatga attgtatctc gttgagggag 1723741 attcagcagg cgggtcagcc aagcagggac gagaccgcag attccaggcg gttctgcctt 1723801 tacgcggtaa agtcattaat acagaaaaag ctaagcttgc tgatatcttt aaaaatgaag 1723861 agatcaatac gatcattcat gcgatcggcg ggggagtcgg ggcagatttc tcaatcgatg 1723921 acatcaacta cgacaaaatc atcattatga ccgatgccga tactgacggc gcccatattc 1723981 aagtgctgct tcttaccttt ttctatcgct atatgaaacc gctcattgag catggcaagg 1724041 tgttcattgc gctgccacct ttatataagg tcagtaaagg aagcgggaaa aaggaaatca 1724101 ttgaatatgc atggtctgat gaagagatgg gggatgtcct gaaaaaagtc ggcaaaggct 1724161 ataccattca acgatataag ggtcttggag agatgaacgc agaccagctg tgggaaacga 1724221 cgatgaatcc ggagtcccgc acacttgtta gggtcaaaat tgacgatgcg gcacgtgtag 1724281 agagacgtgt gacgacgtta atgggagaca aagtagagcc gcgcagaaag tggattgaga 1724341 aaaacgtcgc tttcggctta gatgaagaaa gcaatatttt agaaaatgaa aacttatcgg 1724401 tcgctgagga ggtttaatga ttgtcacagc cagaattatt tcatgattta ccattagaag 1724461 aggtgatcgg cgaccgtttt ggacgctaca gtaaatatat tattcaagac agggcgctgc 1724521 ccgatgcgag agacggatta aagccggtac agcgcagaat tctgtatgca atgcatacag 1724581 atggaaacac gtttgataaa aacttcagaa aagcggccaa aacggtcggt aacgtcatcg 1724641 gtaactatca tccgcacggt gacagctcgg tttatgaagc aatggtgcgg atgagccagg 1724701 attggaaagt tcgtaatgtg ttaatcgaaa tgcatggaaa caatggaagc atcgacggag 1724761 atcccccggc agccatgcgt tatacagagg cacgattatc tccgatagca tctgagcttc 1724821 ttcgggatat tgacaaaaac acggttgaat ttgtgccgaa cttcgatgat acaagcaagg 1724881 agcctgtcgt actcccggcg atgtttccta acctattggt caacggatct accgggattt 1724941 cagcaggata cgcgaccgac attccccctc atcatctggg agaagtcatt gatgctgtca 1725001 ttaagcgtat tcaaatgcct tcttgctctg ttgacgaact catggaagtt attaaagggc 1725061 ctgattttcc gacaggcggt attattcagg gcgttgacgg gataagaaaa gcttacgaaa 1725121 ccggaaaagg aaaaatcatt atccgcggaa aggctgaaat tgaaacaatc agaggcggac 1725181 gagaacaaat tgtcattact gaaattccat ttgaagtaaa taaagcaaac cttgtaaaaa 1725241 aaatggacga gttccgtatt gataaaaagg ttgaaggcat ctcagaggtt cgtgatgaaa 1725301 cggatcgaac agggctgaga gtggtcattg aactgaaaaa agaagctgat gccaaaggca 1725361 ttttgaattt cttatataaa aatactgatt tgcagatcac atataacttc aatatggtgg 1725421 ctatccataa ccgccgtccg atgctgatga gcctgccgtc tattttggat gcatatatcg 1725481 gacaccaaaa ggaagttgtc acaaaccggt ccgtttacga gcttcaaaaa gcaaaagaca 1725541 gacatcatat cgtagaaggg ctcatgaaag ctttgtctat tttggatgaa gtgattgcaa 1725601 caatccgttc ttctagcgat aaacgtgacg ctaaaaacaa tttgatcgcg aaatatgaat 1725661 ttacagagcc tcaggctgaa gccatcgtgt cattgcagct atatcgttta accaataccg 1725721 atatcacagc gcttaaggaa gaggcagaag agctcggtaa aaaaattgaa gagctcgaat 1725781 ctattctgag caatgataaa aaactgctaa aagtgattac aaacagctta aaagcactga 1725841 aaaagaaata tgcagatacg agacgctccg tgattgaaga aaaaattgaa gaaattaaaa 1725901 tcaatctcga agtcatggtt gcatctgagg atgtatatgt aaccgttacg aaggatggtt 1725961 acctaaaacg gacgagccag cgctcatttg ccgcttccaa cggtcaggac ttcggaatga 1726021 aagatacgga caggatgctg catcagtttg aaatgaatac gacagacgtg ctgctgctct 1726081 ttacgaacaa aggaagctac atctattgtc ctgttcacca gctgcctgat atcagatgga 1726141 aggacatggg ccagcatttt tcaaatctaa tcactattga ccgtgatgaa acgattgtaa 1726201 aggctatacc gataaaagaa tttgatccgt cggcatatct tctattcttt acgaaaaacg 1726261 gtatggtgaa aaagacagag ctcactcatt ataaagcaca gcgttattct aaggcacttg 1726321 tagccttaaa tctgaagggt gaagatgaac tgattgatgt acatgtaaca aatggggaaa 1726381 gccagatctt tatggccact cacttagggt atggtctatg gtttggagaa gacgaagtga 1726441 atgtagttgg cgcgcgtgcg gcaggtgtca aagggattaa cttaaaagag gatgactttg 1726501 ttgtctccgg tgagattctt cagcaatctg attcaattgt cttgttcaca cagcggggag 1726561 cggttaaacg catgagtctt tctgagttcg agaagacatc ccgtgcaaaa cgcggtgtcg 1726621 taatgctaag ggaactgaaa aagaatcctc accgtgttgt agcactgttc gcttgcggtc 1726681 ttgaacagcg actaatggca gaaacagaaa aaggcgacag aaaagaactg cagacaaaag 1726741 agttgcggac aaacgacaga tacagcaatg gctctttctt ttttgatgaa gaggaatcag 1726801 gcaaggttac agctgtttgg cgccttcata cagaacaata ataaaaaacc cgctcatact 1726861 atatgagcgg gtttcgtttg ttttttatca gctttcatgg ttggtgaata gatctgttac 1726921 agcatgaatg acttcaatcc cctgccatac aaataaattc agcgctgtga aagaaaataa 1726981 gcctaaaatc accattctta agataaacaa catgtttaac agcctcctca tattttcgtt 1727041 acataatcgg gtgatgttga acatgaagtt tgccgaaata agacgattga taaaatttgg 1727101 ccagtataaa gctttttttc cgctgacgtc tgcgggagta tcccgtactt ttgctttcag 1727161 cggtcagcag cagaacagcc attgcccata aagcggtcag cgtaaatgcc cctgtgatgg 1727221 atttcttctc atcatcagca ttttggccgg ctttcatctc atgcatttcc tgctggtcgg 1727281 ctacggcttt ataatgatgg ccgatatcaa aggcgtgggg aattgagaac aaatgaaaac 1727341 tggcaatcgc caagaataag atggatgctt tcaatatcgt tacttttttc aaatgatctc 1727401 cccctccttt aatattactg aatattttta taataatacc ccaatccatc ctaaaagtaa 1727461 acctgattta ttaaatttaa aaataaattt aactttgtta agtatatatc tttttgctta 1727521 tttttgaaag agaaaacttc ttttattagc gtatgtatac ccggtttatg gtgtgaataa 1727581 aaacatattt taaatgatat gttgtttagg atttattact ttatttatgt gtaaatcaaa 1727641 gagaaaggca agagaatggg aagaaatgat tacattgtta atagggtact ctttttttaa 1727701 agccagtttg caaggaatgt ttttattcgt aggaaaataa tagagaaggg gtcgacagag 1727761 taacatctgg ctatgacaat attcttctcg aaaaaacttc ctaattcgtc atattgtgat 1727821 ataataaaac tcgttatgtt aaaaaatcta acatcaaaat cgaattcgta ttgaattgat 1727881 gaaaacggga ggtaaatatg gagtcttttt tcaatagttt gattaatatt ccaagtgatt 1727941 tcatctggaa atacctattt tatattttaa tagggcttgg attatttttt accatacgtt 1728001 ttggttttat ccaattccgt tattttattg aaatgttcag aatagtaggg gagaagccgg 1728061 aaggaaataa aggtgtttca tctatgcagg cattctttat ttcggccgca tcccgagtcg 1728121 gcacagggaa tttgactggt gtagccttag caattgcgac aggcggacca ggcgctgtat 1728181 tttggatgtg ggtagtggct gcagtaggca tggcttcaag ctttgtcgaa agtacattag 1728241 cacagcttta taaggtaaga gacggggagg atttccgcgg agggccggcc tactatattc 1728301 aaaagggtct tggtgccaga tggcttggca tcgtttttgc aatcttaatt accgtctcat 1728361 tcggcttgat ttttaacgct gttcaaacaa atacaattgc tggagcattg gatggcgcat 1728421 tccatgtaaa taaaatagtt gtagccatag ttctggcggt tttaactgcg tttatcattt 1728481 tcggcggttt aaaacgtgtt gtcgctgttt cacagctaat tgtgccggtt atggcaggca 1728541 tttatattct tatcgcttta tttgttgtca tcacgaatat tacggctttc cctggcgtta 1728601 tcgctacaat tgttaaaaat gctttaggtt ttgaacaagt cgtcggcggc ggaataggcg 1728661 gcatcatcgt tatcggtgcg caacgcggac ttttttcaaa cgaagcagga atggggagcg 1728721 caccaaacgc ggctgcgacg gctcatgtat cccatccggc aaagcaaggc tttattcaaa 1728781 cattaggcgt atttttcgat acatttatca tatgtacgtc cacagcattt attattttgc 1728841 tgtacagtgt aacgccaaaa ggcgacggca tccaagtcac acaggctgct cttaaccatc 1728901 acattggagg ctgggcgccg actttcatcg cagtcgcaat gttcttgttt gcattcagtt 1728961 cagttgtcgg caactattat tatggcgaga caaacattga atttattaaa acaagcaaaa 1729021 catggctgaa catttaccgt atcgctgtta ttgctatggt tgtgtatgga tctttatcag 1729081 gcttccaaat cgtttgggat atggcggacc tctttatggg tatcatggcg ctgatcaact 1729141 taattgtgat tgcgctgctg tcaaacgttg cttacaaagt gtataaagat tacgcgaaac 1729201 agcgtaagca aggacttgat cctgtgttta aagcgaaaaa catcccaggg ctgaaaaacg 1729261 ctgaaacatg ggaagatgag aaacaagaag cataatataa atataaaaca aagctgcatt 1729321 caatagttga atgcagcttt ttcattattg gaaataaatt taatttttcg actcgaatga 1729381 aaaatgacgt gtaaagtccc aattcagtcc agttttcttt gttctatatg tgtcatgtgt 1729441 gtcttattca ttggaggtag agcaaattga caggctttta aacctcccca aaacaagaaa 1729501 ttaggttgat agacaatcat gagaaagatt tttacaatga gttcgtgctc ataagaagtg 1729561 tagagccaaa atgatgcgaa ggaggaaaag atcagatatg aaacggtcaa tctctatttt 1729621 tattacgtgt ttattgatta cgttattgac aatgggcggc atgatagctt cgccggcatc 1729681 agcagcaggg acaaaaacgc cagtagccaa gaatggccag cttagcataa aaggtacaca 1729741 gctcgttaac cgagacggta aagcggtaca gctgaagggg atcagttcac acggattgca 1729801 atggtatgga gaatatgtca ataaagacag cttaaaatgg ctgagagatg attggggtat 1729861 caccgttttc cgtgcagcga tgtatacggc agatggcggt tatattgaca acccgtccgt 1729921 gaaaaataaa gtaaaagaag cggttgaagc ggcaaaagag cttgggatat atgtcatcat 1729981 tgactggcat atcttaaatg acggtaatcc aaaccaaaat aaagagaagg caaaagaatt 1730041 cttcaaggaa atgtcaagcc tttacggaaa cacgccaaac gtcatttatg aaattgcaaa 1730101 cgaaccaaac ggtgatgtga actggaagcg tgatattaaa ccatatgcgg aagaagtgat 1730161 ttcagttatc cgcaaaaatg atccagacaa catcatcatt gtcggaaccg gtacatggag 1730221 ccaggatgtg aatgatgctg ccgatgacca gctaaaagat gcaaacgtta tgtacgcact 1730281 tcatttttat gccggcacac acggccaatt tttacgggat aaagcaaact atgcactcag 1730341 caaaggagca cctatttttg tgacagagtg gggaacaagc gacgcgtctg gcaatggcgg 1730401 tgtattcctt gatcaatcga gggaatggct gaaatatctc gacagcaaga ccattagctg 1730461 ggtgaactgg aatctttctg ataagcagga atcatcctca gctttaaagc cgggggcatc 1730521 taaaacaggc ggctggcggt tgtcagattt atctgcttca ggaacattcg ttagagaaaa 1730581 cattctcggc accaaagatt cgacgaagga cattcctgaa acgccatcaa aagataaacc 1730641 cacacaggaa aatggtattt ctgtacagta cagagcaggg gatgggagta tgaacagcaa 1730701 ccaaatccgt ccgcagcttc aaataaaaaa taacggcaat accacggttg atttaaaaga 1730761 tgtcactgcc cgttactggt ataaagcgaa aaacaaaggc caaaactttg actgtgacta 1730821 cgcgcagatt ggatgcggca atgtgacaca caagtttgtg acgttgcata aaccaaagca 1730881 aggtgcagat acctatctgg aacttggatt taaaaacgga acgttggcac cgggagcaag 1730941 cacagggaat attcagctcc gtcttcacaa tgatgactgg agcaattatg cacaaagcgg 1731001 cgattattcc tttttcaaat caaatacgtt taaaacaacg aaaaaaatca cattatatga 1731061 tcaaggaaaa ctgatttggg gaacagaacc aaattagtta agcttttttt tggcggacat 1731121 cagtaacgat gtccgttttt atcatctaat aggaggtttg cgttgtggat gaaatactga 1731181 aacagtatat ggtgctgtat aaaaaaatga gtaatatgat aaatggtccc gactatccag 1731241 gtaaggaaaa agacatccag catcaaaaag atcagatcga agtttacgaa aaacagctgc 1731301 agcaaggatt ttctacagat tatgactatg atgtgtttgc tgattctgtt atcaaatgcg 1731361 catatggcga tatgacgctg gaagatttag aagccgttta ttatggattg acaacaccat 1731421 ttttttgatt tgtcattcag cagtaaaatt tcaatttctg tctcactaac ttaagtatac 1731481 tttgatattg agacagaaat ttatttattt tgtttacttc ctagaatata tattatgtaa 1731541 actagaaaag atgaagaata aagctttgct gtttttatgt acatcctttc ttcttcctgt 1731601 aattcagcaa caaaataaaa aagcgatttc ccaatcggaa aatcgccaat tcagacactc 1731661 tattatttat gtgtgtcttt gtgctcttaa cgatttacaa caaatgttgt cacgctttga 1731721 gctggaagat gagcccaaaa atgattgcct gatacagtga gattcgttcc aggttgtaga 1731781 ttgctgctgc tgctcgtgat ccatctagat acgtttgaag cagatccatt ctgcaaaaca 1731841 aagttttggt tgactcctgt gttgctttta ttgatggcaa caataacgac cttgttgtca 1731901 cctttatagg ctgacacgta aacgttcgca ttagggtttt tcgttgcatc aatccttaca 1731961 tagccgggac gcacaaactt tgagaaatga gccatattgt agccgcgttt gctgatcgta 1732021 ccatcttctt tcataggtcc atatgatctt cggatgtacc accatacata agcttgaaag 1732081 tccccctcta ccatcgcatt gtgaatatgc tgtgaaacat ccaatgcctc aggccatcga 1732141 tccgccgagt tggtatcact gtttggatag tatacttccg tcatccaaag gtccttcccc 1732201 gctccttttt gtttgaaaag aggataaggg aattggctga cctgggtgcc gtacaggtga 1732261 gttccgagaa tatccatatt ggcaagagcc tgcggatcgt tcaagatcgg gtccgacaaa 1732321 ttcttcaagt attgaaatga ctcaggcgca atgacgcggg cattgatcga gccggcgttt 1732381 tctctcataa agcgaagtat ttcttgcggc gtccaccacg tccactcgtg agcgtaatca 1732441 ggctcgtttt ggaccgaaat cgcgtaaaga ttcacaccat tattcttcat gaaggtaaca 1732501 aaatcgttaa gatgctgcgc gtatgctgcg tacttgttgt atttcagccg tttagccgat 1732561 gtgtcaccat tccgattaaa ggtctcaacc atatcacttg gaggattcca aggagaagca 1732621 aaaacgattg ctccgtgttt gaccgcactc tttgcagtct ccacctcttt ataccaatta 1732681 tttcgatttt catctacatg aattcttaag attgaaaatc ctaactggtt ctgtccattg 1732741 ccaaaagcag tttctctttg agctgctgta agatccccag cccaagccgg atgattcatc 1732801 cctccaaaac cgcgaatcac ttgtttctct gcagatacat taactgttac atcacttgct 1732861 gccaaaactt cagtagcgcc tggccctaac atgactgaca gcatagtgaa acatactaat 1732921 agtacacaaa ttgttttttt tatgcgtgga atcatttatt cctctccttc gtcatgtgtc 1732981 ttttacggta ttaaaaaatc tgcatggcat atccataatg gcgggctgtt ccggtgctgg 1733041 cccgtacttc acccgcctcg tttttaagcg gtcccattac gagtactatc tttgcgtaaa 1733101 ctgccagtaa tcaaaattaa acaagtttcc tgtacctgtt ccggtaaata caaagaatac 1733161 tttgtgcaca ccggttgccc cgcttaccgc agtttctatt tccctccacg tttgcgctcc 1733221 gcctgttgaa ggcacattca gagttccaac aagcttaccg tctgcactgt cgaggcgcac 1733281 ttctattttc ccgcctaaag tggatgctac atttgcttta aatgacctgg caccgcccgc 1733341 tccgaagtct gcatttccta cagcaatcca gtctccattt tgaatgcttg ttacatgctg 1733401 attatttact ggcccgccgg gtgctgtgga cttctctgtc aaaatgcgtc cattccaagc 1733461 aaacgtttca gcttctaccc ggttatatgg gtttaaattg gaaatttgtg ttacacctgc 1733521 ataatttgcc gctacctctt gaatagatcc atctgcatta tgcaccagct tattaatatg 1733581 gggagagcgg tatcctttgc cggccccgaa cagagcggaa ctgacagttt gcgcatggta 1733641 caccacatac cactcgtttt taaaattgaa aacagcatga tggttgtttc cgccacctcc 1733701 gaaaaatgca cccggatttt tcaggaagtg ccctctatat gtaaagggac ccatgggact 1733761 tgaactggtc atgtagccga tctcacccgg gggtttatcg gccgggtgcg tgccgccgaa 1733821 attgatgcaa taggagtaat aatatgttcc gttatacttg tgcaatcccg aatcttcaaa 1733881 catgaaaggc gcatcaattg tagatgcact tccaacaaca ctcgtcatat caggccccaa 1733941 ttttatgact ctagccgttt taggattggc ccattgtccc tgcgttggat ttgaaacgcc 1734001 aggaacgcct ccgccggcat acaggtaacc ggttccgtcg tcatctacaa atactgccgg 1734061 atcaaaaagc catacaacac cagacattcc tggcgtactt ggcgttacga gcggttttcc 1734121 gattgggtcg gtccatggac caatcgggct gtctgcggtg agaaccccga tacctccgcc 1734181 gctgtttgcg aaataaagga agaatttatc cttgccatta atttttttaa ctgcgattga 1734241 cggtgcccat gacgcacctg cccattttgc aattccacgg cctccattag ctccattggc 1734301 acctgctacc ggaatggctc cgtggtctgt ccagttcacc atatccgctg aagatatgac 1734361 gaatactcta ttcaaattgg caaatgaatt atctttaatt gttccgttgc tattatattc 1734421 atagtcatca cttgacatat agatgtagac tcttccgtta taggtcagcg caaccggatc 1734481 cgctcccaaa tgatggtcga taagcggatt tgaattccct atatgttttg caattgtagt 1734541 actagtggca gcatacgcag acttcccaga taagcagctc aataataaaa ctagaatcca 1734601 taaacatacg ctacactttt tcctcatcac ttcacatcct cctttttcct taaaatgggg 1734661 gattttcttt tggaatttga taacaacagg tcacgaagat tgcacgcata aagtagccgg 1734721 aagctgttta gcaatgttcc cagttgttct gaaagctcat cttcatgtgt ctccattctc 1734781 tcttttcttc gaggagatcg caccactcct tcaaaattgt tcaaaaaaac ttccccattc 1734841 ctagcgacca ttgtccagaa aataaaaaga caggattgtt catggcctcc cactaatcac 1734901 attgaacgga gattacatca ttatccaaga tatcccttta tctaacatcc tacatcatta 1734961 aaaaaattgt gtatagaaac ttttggagga gttagtgttc gattctacaa aggaactgga 1735021 tacatttatt cattgataag atggggctaa cactccgttt atatttgtat gttttcagac 1735081 acaaaaaaca gccgttcaat gcggctgttt ttttcaagag tataagacta ttgagcggta 1735141 tacccgcttt ttcatgtttt gttcatattt tattaattgt ttattcaaca ctgtccgcta 1735201 tagtaatcca tatcaacaaa tatgactgcc actcgcatct tttatgaagg gaggttcgtt 1735261 acgctgaaag aaaaaataaa gacattaggc cgtttttgca ccgtaggcgt cggcaatacg 1735321 ctgatagatt ttggtgtctt ctttcttctt accgcttgtc atgtctctta tctgccggcg 1735381 cagatctgct cctatactgc aggtatcgtc aacagctatg tgtggaaccg gaattggacg 1735441 ttttgtgtga aacgtaaggc tgacgggaaa gagatcgtgc gttttctcat gattaatatt 1735501 gccgcgtcag ggatcacctt tttgctgctt tatttgtttc aaaattgcgg ctgctcgctt 1735561 ttggtgagta agctcgccgc cactatcggc ggaatgatga tgaattttat cggaaaccga 1735621 atctgggtat ttggagattc gctgaaaaac atacaggatc aggagtgaag atgaatgaga 1735681 aaaaaagtga gaaaagcggt tatacccgca gcgggtttag gaacgagatt tctgccggcg 1735741 acaaaggcgc agcctaaaga aatgcttcca atcgtcgaca aaccagcaat ccaatatatt 1735801 gtagaagagg ccgcagagtc aggaattgaa gatatactga ttattacagg gagaaacaaa 1735861 cgctcgattg aagatcattt tgatcggtcg gcggaattgg aattcaatct ccgggaaaaa 1735921 ggcaagacgg agacacttaa ggaaatgcag cagattgccg atttggccaa cattcattac 1735981 atccgccaga aagaaccgct cggattaggc catgcggtgc tgtgtgcgga gcattttatc 1736041 ggagatgagc cttttgctgt tctcttaggt gatgatatta tggtgtctga aacaccggct 1736101 cttcggcaat taatggatgt atatgacgtt tatggcacag aggttgtcgg tgtacagtca 1736161 gttctccctg aggatgtcag caaatatggt attataaata catcagggtc tcaagggcat 1736221 gtatatgaag tgaacgattt agtggaaaag ccttctcctg aagaagcacc ttcggaaatc 1736281 gcagtaatgg gacgttatgt gctgaattct tcgatcttct ccgttttgaa gacaattggc 1736341 agaggcgcgg gcaacgaaat tcagctgaca gatgcgcttc gtgaggtttg ccgtaaggag 1736401 ccgatccatg cccggctgct ggaaggaaat cgatatgaca ttggcgataa gctgggctgt 1736461 tttaaagcga gcaccgaaat cggcttaatg cgtcccgaaa tgagatctca gcttttggcc 1736521 tatttagaag atgtgatcaa acgggaaacg aaagaaatgc tgcggtaaaa aaattgtaac 1736581 catcttgctc gtcaatcagt catataatag tgaaaaagat taggacaggt tgtgaagaat 1736641 gtgggcagtt tgataagcga aattttaaca tggctgacga acatgggata tgcgggtatt 1736701 gcgattgggt taatgattga aatcattccg agtgagattg tattagctta tggcggctat 1736761 atggtatcgg agggcacgat tggatttatt ggcgcaatta ttgcgggtgt tatcgggggc 1736821 accattgccc agatctttat ttactggatc ggtcgctatg gcggcaggcc atttctggac 1736881 aaatacggga agtatttatt gattaaaaag catcatatcg atatgtcgga aaactggttt 1736941 cagaaatacg gcgccggagt tgtcttctcg gctcgtttta taccggttgt cagacatgcc 1737001 atatccattc cggcaggtat tgccagaatg ccttttctca aatttgtggt actgactgtg 1737061 cttgctatca ttccatggtc tatcctgttt gtttatttag gcatacagct aggaagccag 1737121 tgggatgatg ttgagaatat agcaggcact tatacaacac cgattatgat attggctgtt 1737181 gtcgtgatag ccctttattt tgtgattaag aaacgtacag ccatatttaa acgatagcta 1737241 gcggatatgc ataggggtga ctgacgctcc cctatgcata tttttttact tgcgatgttg 1737301 atttgccagc ttcagattct ccgctaaaaa tgcgacaaac acttcatccc gcacgagcga 1737361 tgcggcataa tttctcttaa taaaccattc tgcctcttca aacgctgcga atgtttcgtc 1737421 ttgggtttct ccgttaattt gaatattcca ttcgttgtct aaagggaaaa gaaaaaatct 1737481 catttgtgcg cgattttcat ataatgatcc attcgcagat ccctttagat tatagatgtt 1737541 acggaaggca tccggccgta caggatcaat acggaaagct tcagctacaa acaactcgta 1737601 tacttcatcg gttattgaac agccggacgc ttttgcatgc cctccgccgc catatcggcc 1737661 ggcgatttct gacacatcga tgtaatcatg aatggtgcgg agactgactc gttttgaccc 1737721 catgctcaaa atcgcaatgt aatcgaggtg cgggttatct ttccctagcc tgttccccag 1737781 ctctgaatgg tacgattcag cgtgaacgat gcctacacag tgttcgtgaa caaaggtttg 1737841 taccatttcc cttttctttc tgcggaggta gcgctcgatt ttttcgtctt ctaaatcaag 1737901 cagtttttct tcaaaatcat cgaagaaaaa ttcgtcatgc gtggaaaggc gctggatcat 1737961 ttttgcttca aattcatcga ttgacagcaa aaagaaaaga tcattaagcc gcttcgcctg 1738021 tttttgatcg taccgctccc actcccatgt atcgtattgg cggacgagct ctgtgaattg 1738081 atctaaggcg tttgtcggtt tcatgaagcc attttcaatg agatagccat ataaaagcga 1738141 tgtcgcggat gtgagccttc catcatcgta ttccacctgg acaaatcccc attcatgctc 1738201 attcaaatga agggctgttt tatgatggtc aatgagcttc actttgcccc ctgcatgaac 1738261 atactcattc aatctctctt cgttttcttc attgacggcg agatcggtga tgaataacgc 1738321 gtcctgtctg ttgctctcct tcgctttttc taaaaagtac tgcacctgtg cgtttaagcc 1738381 gttgacagag ttataccgga tctctacgtc ttttccgaac gccaattttg ctacgattcc 1738441 gcatcctact ccgtccaagt cgttatgtga atataaatga tacataatgt aggccccttt 1738501 ttatgataaa ctgacaattg ccgctagagg tgcggcagcc tttatttact attctaaaaa 1738561 accaagcgtt ttatgcaatg gtaattagtt gacataatgt tgttattgta aatatataaa 1738621 ggagcgcttt ttttgcgctc ctaagttctt gcttttacac cggataaacc ggatgctttc 1738681 gattggtaaa tgtcatttcc tttgtcatgt atgccttgag ccgtttggcc agctcatcac 1738741 gcagcgaatt ggctgggata acagcatcaa tgatcatttc tgaagccaga cggtagatat 1738801 tgatgtcctc tttgtattcc tcccgtttgc tgctgataaa tgcggctctc tcttcttctg 1738861 gcagctcggc gattttttta gcgtagacag cgtttacagc ggcctcaggg cccatgacgg 1738921 cgatttgggc ggttgggagc gctagacagc aatccggttc aaatgccggc cctgccattg 1738981 catacaaccc cgccccgtaa gcttttcgga caatgacaga gagttttgga acagttgcct 1739041 ccgacatcgc agaaatcatt ttcgctccgt gtctgataat cccagcctgt tctacttttg 1739101 tgccaatcat aaaaccgggg atatcggcta agaacagcaa tgggatatga aaagcgtcac 1739161 ataaggtaat aaacttagcc gctttgtctg ctgaatcgtg gaataagacg cctcctttta 1739221 ccttcggctg gtttgcaaca atgccgacag gctgtccgtg gattcgtgcg aggcccgtca 1739281 ataattccgg tgcaaataag gctttgatct caaaaaatga gtcttcatct atgacccgct 1739341 caatgagctc atgcatatca aaaggtgcgt tttgattttg cggaatgacg tcggcaagcg 1739401 gagtttcgaa gtgttttggc gggcgtttct catgaatggg cgctttttct tgaaaatttg 1739461 ccggaaagta agacaaataa gcccgcacca gctgtatggc ttcttcttca gtttctgcaa 1739521 gaatatctcc gcagccggag attgagcaat gcatacgggc gccacccatt tcttcgagag 1739581 acactttttc tccaataacc atttccgcca tccttggcga acctaaatac atggaggcgt 1739641 taccgtctac cataacgacg atatcacaga aggccggaat ataagcgcct cctgccgcag 1739701 atggtccgaa aagcagacag atttgcggaa tgcgtcccga taatttgact tgattgtaaa 1739761 aaattcttcc tgcaccgcgt ctccctggaa agacattgat ttggtcggta attcgggcgc 1739821 ctgccgaatc gactaaataa atgagcggac agtttaattt ttcggcgatt tcttgaattc 1739881 tgatgatttt ttcaactgtt tttgctcccc atgaccccgc tttcactgtt gaatcattcg 1739941 ccatgacgca aacggtttgg ccgccgattt tgccgatagc ggttacaact ccgtcagcgg 1740001 gaagcccgtc tgacatacat tccgcaaaaa aagcgtcttc tagctcaatg tcatcgtcaa 1740061 agagaaggga aagccgctct ctgacaaaga gcttgccttt ttcccgattg ctttgatgat 1740121 acttttccgc tccgcctttt cgaatccgtt cagcccgttc tgttcgttcc ttttcataat 1740181 ccatcagcat tgcctccctt ttatattccc ttgtatacgg cccgtctttt ttcttgaaag 1740241 gcctgaagcc cttctctcct gtcttttgtc gggatggttt gttcatacgc tttttgttca 1740301 atcgcaaggc ctgtagcaag atctgtctcc aatcctttat tgattgcaaa tttagcctga 1740361 cggacagcga tcggtccgtt ggcagaaatg gctgcggcca gttcctctgc ttttggcata 1740421 aggtcacaag gagccgtgac atgctctaca aggccgattt cttttgcttc gtgtgcggtc 1740481 acgcgtctgc ctgtataaat gaattctttt gcttttcctc tgccaatcag ccggggcagc 1740541 ctttgggtcc ctccagcgcc cgggataata gctaaccctg tttccggaag tcccagcaca 1740601 gctgcttcag ttgcgattcg aaggtcgcat gccaatgcca attctagtcc gccgcctaat 1740661 gcgcttccat ttatcgcagc tatgaccggc tgcggcaagg catcaagtaa agccgccgtt 1740721 ctttgaatga gagatacact ttccagaacc tgatcttctt tcagttttat ccgttccttc 1740781 aggtctgccc ctgcacaaaa cgctttttca ccggtgcctg tgaggatgac gcaacggatg 1740841 tttgagttaa attcaatttc ctggataatc atttgcaggt ttctaagcat ttccgctgaa 1740901 agagcatttg ctgcctgagg cctgtttaag gtgatcaacg ccatatgttc atttttaaca 1740961 gtaaaaagaa tagaatctcc cattgtatgc gtcctccctt ttatcaagat gatttaaaca 1741021 cctgtaaatt tctgctcggc agcggtttgc ccattttttc ttcaatccat ttggccgcag 1741081 atagcagttt ttctagcttt acatttgttt tgatatccat ctgttcaagc atgtacacga 1741141 tatcctcagt tgcggcgttt cctgatgaac ctggcgcata tgggcatccc ccaagcccgc 1741201 ctgccgagcc gtcgaacacc gtgatgccca tttggagtgc tgtgaccatg ttggccagag 1741261 cggttcctct cgtatcatga aaatgcaggg caatttgatt agccgggaat cgtgccaaaa 1741321 gagcttcaag tacagtttcc acttgggcgg gattagctgc tccaatcgta tctccaagcg 1741381 acagttcaga aatcccaaat tcaaatagag cttctgaaag gcgaatgact tgttcaatgg 1741441 ggacatcttt ttcgtacgga cagccgaaaa cagtcgagag gtaggctctt gttgtgaggt 1741501 ttgctttttg tgcgtcgttg tttacttgtt tgagtatatg gagggattca gaagtggatt 1741561 tattgatgtt ttttctgttg tgcgtctcgc tggcggacat aaaaacgcaa gcctcgttaa 1741621 tgcctccttc aagtgcattc tccagtcctc tttgattcgg gacaagtgcc gcgtacgtta 1741681 cccctttttc tcggtcgatg ccttttgcta catcgatagc atctcgaagc gccggaatcc 1741741 atttcgggtg aacgaaggat gtgatttcaa tatacgacag ccctgtccgg gaaagctggt 1741801 tgatccaggt tattttatcc tctgttgcga tccaaacggg ctcgttttgt aagccatcac 1741861 gcgggccgac ttctttgatt gtcacttttt taggatatgg catggtcttc ctccaaatta 1741921 ttgagtggaa ttgctcagtt cgagcagtac gtctccttca tttacaaagt cgccttcctt 1741981 ttttttgact tcttttacga ttccgcttct atctgcaacg atcgggattt ccattttcat 1742041 cgattccaaa atggctacct cctggccctt ttcgatttgg tcgccggctt tgacgtggac 1742101 tttccacagg tttcctgcca tttgtatgct aaccgtcatg acaactgcct cctttatagg 1742161 tgctgtttca aaaagtcagt cgtgacatcc ccttctttaa atgcctttgt tgccgcagcc 1742221 tgtatgagga gcggaaggtt tgttttgatt ccctctacac gatagtcgcg aagcgctgtc 1742281 tctagttttt caattgcttc tgttctggtt tggcctttga caatcatctt agcgatcatc 1742341 gggtcataaa aaggggtaac ggtgctgtct tttgctaccg cacattcgtg tctgactcct 1742401 ttttggtcag gaagtgaaaa cgcagtgatc gtacctggtg acgggaagaa ggtcttggga 1742461 tcttccgcgt atattcgaac ctctatcgca tgcccgttcc gttggatgtc tttttgggag 1742521 aatgtgagtg tatggcccgc agcaatccgc agctgctgct caactaagtc caggcctgtt 1742581 atttcttcag tcacggggtg ttcaacttgc agtctcgtat tcatttcgag gaaataaaaa 1742641 ttttgtttct ggtcaactat aaattcgatg gtgcctgcgt tcgtatagcc gattgccttc 1742701 gctgctttta ccgctgtttg accgatcttc attcttagtt catcgtctac aaatggagac 1742761 ggtgcttctt caatgacttt ttggtggcgc ctctgaacag agcaatcacg ttcaaacaga 1742821 tgtactgtat ggccgtgttg atcggccaaa agctgaacct cgatgtggcg cgcatgttca 1742881 ataacttttt ctatatacat agacccgtca ccgaaaaaat ctgctgcgcg ctttttgttt 1742941 ccctcgtacg ctttttttaa tgcttcttca ttttcaacac gctgcattcc gatgccgcct 1743001 ccgcccgctg aagctttcag catgacagga tagccgattt gacttgcggt gcggcaggct 1743061 gcctctatat ctccgaggga ttcagaaacg cccggcacca cagggacacc tgcagcctcc 1743121 attgcttttc gcgcttcaat tttgctgccc atctttgcga tgatatcagg ggaaggtccg 1743181 ataaacacga tgttttcttg cttgcagcgt tcagcgaacc ggctgttttc tgataacaat 1743241 ccatatcccg ggtggatcgc gtcggctttt gcttttttcg ccgtctttat gattctctct 1743301 atatttaaat aactttcact gactctcgat tccccgatca aatatgcctc tgtagcggct 1743361 tttgtatggg gcgcgtcctt gtctgcttct gaataaacag cgaccgtttt aatgccgaga 1743421 cggctgcatg ttcggataat tctcattgca atttcaccgc ggttggcgat cagtactttt 1743481 gtaaacatga tttcacctca ttgacttgat gataagttga acatttcaat cgttttttct 1743541 cgcagtttat atttttgaat tttgcctgag gccgtcatcg gatagtcatc cgtaaaaata 1743601 acataacgcg gaattttgtg gcgggcgatt ttccctttgc aataggcttt aagctcatca 1743661 ggtgaaacgc ttttaccgtc tttcagttta atccaggctg cagcttcctc cccgaatttg 1743721 gcgtcaggca caccaaccac ctgtacatct aaaacagcgg gatgctggta taaaaattct 1743781 tcaatttccc gcggataaat gttctcgccg cctctgatga gcatatcttt taatcttccg 1743841 gtgatgcggc agtacccgtc ttcatccatg acagcaagat ctccggtaaa cagccatccg 1743901 tcatgattga ttgcttttct ggtcgcatct ttgtctttat aatagccttt catgacgtga 1743961 tagccacggg tgcacagttc tccctgcatg cctctttgaa cttcttgaca tgtcccgggt 1744021 tctacaattt tcacctcagt atgtggcagg gcacggccgg ttgtttcgac tcttcttatg 1744081 aaggaatcat ttgctctcgt ttgtgtaatg actggcgagg cttcggtttg tccataggcg 1744141 atcgtaatgt ctttcatgcc catcctttca atcacagctt tcatcacttc acttggacag 1744201 ggagagccgg ccatgattcc tgttcggagc gtcgatagat catatgcatc aaaatccgga 1744261 tgatgcagct cggcgataaa catggtaggc acaccatgga gcactgtgca tttctctttt 1744321 tctaccgttt taaggacggt aacgggatca aattcttgca cgggtatcat ggctgccccg 1744381 acggatacac atgccaaaac cccaaggacg catccaaagc agtgaaaaaa cggaacaggg 1744441 atgcacatgc ggtcttgaga ggttaaagcc atacattcag cgatattagc agcgttattg 1744501 atgacattga aatgggtcag catcacgcct tttggaaacc ctgtcgttcc tgatgtgtat 1744561 tgcatattaa tcacattgtc tttatccagg ctgttcattc tctcttcaag ctcagcatct 1744621 gtcactgttt tcgccaatat ctctgtatcg tcccaatgat acatgccaga caatcgttta 1744681 ttgccaatat agatcagcgt ttttaaaaag ggatagcgtt cagatttcag ttggccgggc 1744741 tttgcttctt gcagttctgg aattaaactg ttcacgatgt ctggataaga agtgcccctg 1744801 tatgaatcca tgataataag cgccgcggca tccgattgct ttaacaagta atcaagctca 1744861 tgtgcttgat aattggtatt gacggtcacg agcacggctc cgatcttcgc agttgcgaac 1744921 tggacggcaa gccattcaga gatattagaa gcccatatgg cgacgtggtc tccttttcca 1744981 atccccatcc gcatgagacc tttagcggtt tgacggcaca gactgtcaaa ttgagcgtac 1745041 gtatagcgga tatttcggtc tggatacaca acagcatctc gatcgggata cgcatcagct 1745101 gtttgttcca gcagcctgcc gattgtggaa tggatgagtt cagccattca ttgttcctcc 1745161 tttcttaatg ataggaaagc gtttacattt ttattttaaa agctgtctgg cgatcacgag 1745221 acgctgaatt tcagatgtgc cttcaccgat ttccattaat tttgcgtccc gcagcatccg 1745281 ttccacccca tactctttca tatagcctga acctccatgg atttgaatgg cttgattgca 1745341 agctcttgtc gccatttcag atgcgaatag cttggcgtac gccgcttctt tggtgaacgg 1745401 gcggttatga tctttcagcc aggcggcttt taacaccatt tgccgtgcca gatcaatttc 1745461 catcgccatg tcagcaagct taaattgaat cgcttgaaag gaagaaatcg gctgtccaaa 1745521 ctgctttcgc tctttcgcat atgccaatga tgcgtcaagg gccgcttggg caatgccgac 1745581 tgcaagagca gcgatggaga ttcgaccacc atccagcgta tatagaaact gtttaaaccc 1745641 ttttgttgga tcgccaagta agttggccgc aggcactctt acatcttcaa gcaagatttc 1745701 cgctgtattc gaaccgcgga cgcccatttt atcgtacggg ctcgtaatcg taagtcctgg 1745761 tgtgtcagtt ggcacgatta atgcggagat gatgtttttt ccgtctttgt ttttgcctgt 1745821 tacggcggtt acaataactg tgcgtgcgta gcttgcatta gtgatccagc acttttcgcc 1745881 gttgattaca tactcgtcac catttgaaat cgcttttgtt tgagtgcctc ctgcatctga 1745941 gccggcattt ggctccgtca ggccgaatga tccgagtgct gtgcctgaag ccagcggcgt 1746001 caaatgcgtc tgtttttgct cttctgttcc gaagtagtaa agagggcttg cgcctagcga 1746061 gaccgctgca gcatagctta atccagtact gccgcaggct ttgccgactt cttcaaccgc 1746121 taaggcatat gaaatcgtat caccgccaga tccgccgtat tcttctggaa atggaatacc 1746181 catcagaccg agttcaccca tttttttaaa tgtttgcatc gggaactcgc ctgtttgatc 1746241 tacatgttca gcgtgaggag caatttcttt tttcgcaaaa tcttttacca tttcacgcac 1746301 catttgttgt tcttttgtca gctcaaaatt cacatcgttt cctccttcac atctttgtaa 1746361 catcctatta ggcgagttct ataatcattc cctgacaaga aaagtctgaa aattaaaact 1746421 gaatcatttt ttatgtgata atatcagcgg gatgagcaaa tacatgcagt aggcgcatac 1746481 catccatatc gtaaacgcaa taacttggcc ctttgataaa gccgggaaga tgaggggaag 1746541 attccaaagg gaaatcgtat ccatcaataa accgaccgct gatccccata tacctagctt 1746601 gatcaccgcg aactgtgatt gatcgagttt ttgatagaga aagaacacaa ggcataaaac 1746661 aagagcagtg cccgctccca agagaagaaa gttcggcaaa aaggcttctt cagccggatc 1746721 agtcaacaca gcatctccga acagcacaaa aaataatgtg gcacctaacc agactagaaa 1746781 tgaaaacgta aaacacgtcc tgtacgtgtt tctcttcgat tttattttta tttagtacta 1746841 gtttctcaga ttccaataat ggtaaatgtc caaacaccgc ctccatattc atgtgaatct 1746901 cacctttgtt ttttaaaaaa ttcagcggtt taccatcgtt tcctgtccca aaatcacttt 1746961 ttaaaaaaag acgacttaga aagccgtcct tctcatttct tattttgttg ttcgtttgga 1747021 agctttgctt tcgttatgaa gccggtctgc tgaagtgaca taatacgtat atttcttgtt 1747081 gggatctgcc gtgttatcta agaaggtttg ctgctcatgt gtttttcttt gcgttgccag 1747141 caatgttctc tgctttttcc cttcggctct gtatatcgca taataggctg tttctttcgt 1747201 tttttgattt gatgggtgat ctttaatctg cagaagattg ccgtttttgt cttcggtgac 1747261 tttcgtaagc ttcggttttt ttggggcggt attgtcaagc caaggcattt gcggaaccag 1747321 tgccggcttg ctgtaaagat cggtgctgag actgtctttg atgccaagcg gatttttgtt 1747381 gaggtccttg aggctgaaat gcatgcttcc tttcaccagt tcaagctggc ggttcaaagt 1747441 gatttgccgc acatattcct caggatcgga ccaaggcgga tcaaaattgt tattgatttt 1747501 atatgctgcc tggccaatat ataagtgaac aggcctattt ttgacttcat tgctccacca 1747561 atcagccagc acgtcgtaag ccgctgcgtt aaagccgata ctccaataaa tttgcggagc 1747621 aatataatcg atgtcgcctt cttggatcca atgccttgtg tctgcatata gatcgtcata 1747681 atttctgacg cctgcttttg tattcgatcc ggtcgggtca tctgcggcgt ttctccatac 1747741 tccaaaggga ctgatgccga atttgacata cggttttgca gctttaattg tttggttgat 1747801 ttgtttgaca agctggttca cattgtcccg ccgccagtca tcgatattag aaaaagcgtc 1747861 ttttccgtat tgttcgtact gtgcttgatc aggaaattcc tgtcccgcta ttttataagg 1747921 gtaaaaataa tcatccatat gaacagcatc gatatcataa tgttttacga cttcttcaat 1747981 gcctttgacg ataaaatctc tcgcttctgg aatgcctgga tgataataca gctggtttcc 1748041 ataggcggca acccaatctg gatgttttct tgccgggtga tcctcagaca atttattaag 1748101 atctgtatga ttcattgtaa tacggtaagg attaaaccac gcgtgaaatt ccaaatttcg 1748161 tttatgggtt tcttcaatca taaatgcaag aggatcatag ccggggtcct tcccttggac 1748221 accggttaag tattccgacc aaggcccgta agctgacgga taaaaggcat cagccgtcgg 1748281 tttaatctga acgataacgg cattcattcc cattttttgc acatcgtcca gcagtttgat 1748341 atactcctgt ttttgctctt tcacagataa cccttttttg gacggccaat caatatttaa 1748401 tacggaagca atccatacgg ctctcagctc cctgtcagac tgcgcattgg ccataaacgg 1748461 aacggaaatg acaaacgttc cgatgatcaa gctgacaagg aaacggacaa tcgacttttg 1748521 gcaaaccttc attctgtttc ttctccccca ttacatcact ttcactattc gctattacgg 1748581 tattcccggg ctataaaagg gtgattaaca gaatgtctat ctcactaaat aaacgaaaaa 1748641 agtcctaaag catgttgtga accgctttta ggacttttta tcattcatca tggtttgcag 1748701 actttttaac acatcaataa gttttacgcc gacaccgaca gccgtttcaa ggatcgcttg 1748761 tgctccggca atggctaaaa taaagatcag cggtattgca atacgaggca aaaaaagata 1748821 gccaagtccg atcaagatgg cacaccaaac accggcacac cagtagcaat tgagcatgta 1748881 tccaaagtta gaagccggca cgcttttttc atctacatgc ccgttttgat caacaatcct 1748941 tttctttttc ataaaaggtt ttcggataaa ttctgtgatt ttgtcaaata caatcaaatg 1749001 tgtcagcctg taactggcta gaatcagcat gataaaagtt agaaaagaaa gacggtccat 1749061 tgagaagcct ccaagaaaaa ggatgatgtt atcattccca agtgtccctt atccattctt 1749121 gatacaaaaa gaaagacgga cagagaatgg cctctgtccg ctaatccgag ctcattccct 1749181 ccagttctca taataagagg ataagaaaat gtagaaaaaa gcagaaaaat gacaataaaa 1749241 gaaattatat gactatataa tccatatatg cactatatta acggatattt tttaaagtac 1749301 aataaaaaac attaaatttt tataacattt tttttgaata tagtattatt tctttatttt 1749361 tcgtttcttt ttttatcaaa tttccggata taaagtgata aaagtattgt tttacataag 1749421 gtcttataca ctacttttta atcggactaa ttttcttttg tgcatcattc ttctaattgt 1749481 tggaaggttc gacaaagcgt tattacagac ataaaaaaac ctgttttctc ttggaaaaca 1749541 ggtctcccgc tattattgat ttgccaaaat gacagcgatt tgatcctcaa tatcttttcc 1749601 atcctcttca tcaatcaatc catttagaag aatagagaaa acaagttttt ttccgctctt 1749661 tgtttctgcg taccccgata gagagcttac cgtactgagc gatccggttt ttgctcttac 1749721 ttttccttgt gcaggagtgc ctttcatgcg gtttctcagc gttccgccca ccattctgtc 1749781 aggattcccc gcaacaggta aagaatttag ataagccgag aaccaactct gatcctgaat 1749841 gtcatataac agctgtgaaa gttgatctga ggatacagca tcaatatgtg agattcctga 1749901 tccgtccctt aagacgagtg atttagaatc aacaccaaat tccggaagcg tactgtttaa 1749961 cacttcgagc cccttttccc agctcccttc tccttttttc actttcccca tctcttttac 1750021 gagcacttcg gcatgtccgt tattacttaa tttcatgaac ggcacaaaaa gtttcgataa 1750081 aggcattgag cgatgagaga gcagcacatc tgaagaacta ggtgcttcac ccgtcttgat 1750141 gtcccctttc acagtaatac cttgtttttt tagtgactgc ttaaataaat ctaaggcata 1750201 tccggcaggc tcccagacag aaatccattc ctttgtcttg tttgcgtcaa ccggtacgct 1750261 cccttcaatt gtaatcgtgt ttgttccatg ctctctttcg attgtgaggt ctttctctga 1750321 accggcagca gtcgttttag catcgttctt tatcgttata taatcggttt tcggagagac 1750381 agacacggca ggctcttccc cttctttttg atttggggtg acctcaacaa tcacagtgcc 1750441 tgcatcatag tcttcgtttg gagacgctgt tagagcggag attggcgcgc cataatatgt 1750501 gtattcatcg ctccaaggca tatcaggtga taatcgcatg tcatcatgcc acgtatcatc 1750561 accgatcaga ttgcctttaa ttacttttac gccggaatgt ttcaatatct cagccatttt 1750621 gtcaaaatca gatggtaaaa gtgtcggatc gcctttccct ttcaaataaa ggttaccatt 1750681 cagctttttc cctttcagtg ttccatccgt ccggacctcg gttgtaaaag aatagttctc 1750741 gccaaggaca gaaagtgccg cggccgctgt caaaagcttt agagaagagg caggcctcat 1750801 tcgggtgtct cctgaatgtt catatagaac agcacctgtt tccgcagagc gaacggtgat 1750861 gccggccatt gcgccttcga gggcaggatg atcagctaaa atcttatcga tctgcccgga 1750921 aagtgcatct tgtttttcag cggcaagcgc agcctgatgc atataaggca ccgaagcaac 1750981 gacgaaaagc agtaaaacag caacataaag ctttatgctt tttttcatta atttccccgc 1751041 ctctctgcgc ttcatcattg gctattgatg attcagttca atggtgatac tgcttttagc 1751101 tgtcgtttct tctcccggct ccagcacttg taaaccagtg agtgacgaag gtaaatcaag 1751161 attcactgcg tttgtcaccc atgtgtaagg ctcagggcat aaataccctt gttttccgtc 1751221 cgcattgtat acaacccaat gtttaaactg ttcatctgcc ttataaataa tgctgatatg 1751281 tgcatgctga tgataaatga ctgcctggtt ttctccgccc ctcttctgat aagaagataa 1751341 aaagacatca tccagctgct tgtggcgcaa atccattcct tcatgcaaag cttctttata 1751401 cgggacatcc atcagcttcc cggtcggcag caggcgttca tccaactccc attgctgatc 1751461 tgctgtcagg gagaataacg agctttctgc cggaaatata aatgtagtat gataaccaat 1751521 tccccaagga aacgcttcct ttcctttgtt catgaccgtc gcatgtttaa atagggtatt 1751581 ctccttgatc gtgtatgtca tccgaacgac ggcatgatga ggaaattgct tctgcacatg 1751641 gggaagctca gaaagatcaa tttctgtttc aacaatcact ccttcatcag tttgcttcgt 1751701 ggtcacgaca ttccactttt catggtaaag aaacccgtga agatggttgt gtttatcctt 1751761 ctcgttgata tcaaaatgat acgttctgcc ccggaaactg aatgtaccgt cacttatgcg 1751821 gttaggcggg aacaggattg gaatgccata caatgttggt gtgtcgtgaa aactttctgc 1751881 tgtttccggt tcacgcaaaa gctggacatt tgttgttttg tccacgagag aaatgacgtt 1751941 gctcccccac tcagggacaa caatcatttc tagatgttcg ttgcccgctt tgatggccgg 1752001 cgttcccaaa tacgtgattt tctcaataaa gtttgccatg tttactcaac ctctccttga 1752061 ttcattgcta gtataagaat tcaatgtact gtaccatatt tcctccattt tatattttcc 1752121 cctatcaaat aaaaaaacac cgttcaaact tatgaacggt gtgattcgga ggctattgga 1752181 tgagacgtgt gatttgtttc tttttccaga cgaattgata atacccataa atcaacagca 1752241 agctgacggc aaacgcagct ggataaccaa cccagacgcc gagtatttca agctttgtat 1752301 agtgagaaag gacgaaagcg acaggcacct ctactcccca gattgcaaaa atactgatga 1752361 cggtcggcca taaaactgtt ccgcttgccc gcatcgttgc agaaataatt tgggcatttc 1752421 caaacagcaa atagctccac agtgtaatca tcaaaagacg gtgcgcaatg taaagcgtct 1752481 cttgctcggt taaaaataac gataaaatct gatgtgaaaa aacatagatc agaatgatca 1752541 gtacgccgcc aatgatataa ttcagccaaa tcccaacgcg aatgacctgc tttaagcggt 1752601 caaactcgtt tgctccgatc gattgcgcag cgaaaataga aaccgcaata ccaaggctga 1752661 cggccggcat ctgtacatag ctggccacct ggttgaccac tccgtatgca gctgttgcat 1752721 tagagccgta atgattgacg aatgaaataa ccgctatctc tgataatgag acaagaatca 1752781 tattgatgct tgctgggacc ccaagacgca gcaggagaac cagcagttcc ttatccattt 1752841 tcaaataacg acgcactgtt ttatcaaatt gcagcgggtg ttttcgcttt cgtaaataca 1752901 ccattaacac gagaaaagtc gcaatcgtgg aaatgacagt tgcatatgcc gagccgtata 1752961 tgcccagttt cggaaaacca aacatgccaa ggattaaaac aggcaaaagc gcgatgttga 1753021 tgaccgtgct cacaatcagc gtataaaacg gtgtcttgga atctcctgtt ccgcgcaaaa 1753081 aggtagtata tgcaaaatat aaaaacataa acggcatagc ataaaataaa atacgtgcat 1753141 agttagcgct gacatgaatg acattttcag gtgttcccat taaacgaagg atatccaggg 1753201 tgaaaatact gccgataacg gctaacacaa cgcctaataa aaatgtaaac gtgagtgtcg 1753261 tcccgacaac agcctttagc cgttcctcat ttttcgctcc gtaagcttgt cctatcagaa 1753321 tcgaacttcc tgaaccgatc ccaatcgtaa atgagattaa aagaaaaaat aacgggaaaa 1753381 aggatgatac agctgccact gcatcaacac cgagccatct gcctacagcc atcatcccga 1753441 ctagctggcc gactgattgc agcacattgc tcagcagaag cggcactaaa aagagtgaca 1753501 tcgaccgcca aactgatggt ttgcttttct tttgagttac aagaggttct tgtgatgttt 1753561 ccatattaaa ggactccttt atttgaaatc gtttttaaac atgccctcat tttttgacaa 1753621 aaacaggata tgtaacatgt tattattcat cactgcactt atgaaaccct tcccgattct 1753681 tctaatttta cacatctttt tagcttatga agaataaact agcaagtaat ggcgtatttt 1753741 ttgtgagtaa aagaataaaa aataatttat gcaaaagtat tgtaatctat ccgtaattat 1753801 tgtaacattt gtaacataag agaaagagat tttgaaggag agagcgataa tgaaaaaatg 1753861 tcttctattt ctaacaacca ttgcacttat tctgtcatta agcacaaatg catttgcgaa 1753921 aaatacatca ggcgatttat cacaaaaaca agcattacag ttggcattat ccgctagaga 1753981 acatttttgg aacaccatga gcggccacaa tccgaaggtg aaaaaagcag tttgcccatc 1754041 aggcacattc gagtatcaaa atcttcaata tgtatacatg tgcagtgatc taggcactaa 1754101 agcaaaagcg gtgaattatt taactcctat ttttacaaaa acagcaatcg aaaaaggctt 1754161 taaagattat catttcactg tttcaaaagg aaaacttgct gttccaatcg gtgacggaga 1754221 caatcttttg aattggaaaa aatcaactgc taaactgatc tctaaaaaag gcagcacaat 1754281 cacatacgaa tttactgtcc ctacattaga cggatcccct tctgcaaaac ggaaagtgac 1754341 atttgtgaaa gaaaataaaa aatggaaagt caatcaattt gacgcagtta tataagaaaa 1754401 acgcccggta taagcgggcg ttttttattt ggtttgcata aagaaagaca acaggcgaaa 1754461 agtgcctgtt gtctttttgt gaatataacg ctctaggaga gattcgaact cccgacctgc 1754521 agtttaggaa actgctgcac tatccgctgt gctactagag cttttggtat ttatatagta 1754581 gctctgatga tcaatatttt caagcgattt gtattaaagc cctccaaaaa ccttatatgc 1754641 ggctcttgtc gtatcttcat caataccgat ataccgcatt gtaattgatg gtgatgaatg 1754701 attcagtatt ctctgcagct cggcgatgtc tttcgttcgc tgataaaaat gatagccaaa 1754761 cgttttccgg agtgtatgcg tccctatctc ctcaagtccg cacgctgcag cggcctctct 1754821 taaaattctg taggcctgaa tgcgggaaat cggcttcctg gtccgcactg atttaaaaag 1754881 atattcgttt tccttcatgt ctttcgtata ctcgtatatt tcctgtttca gcgattctaa 1754941 aataagaatc tttcttttct ttttcgtttt gctttcagtc gcccataaat gatctttatt 1755001 ttgaacgtcc ttcacttgca gcggcagaat atcagaaata cggagcgcgc tgttgatgcc 1755061 gaaaataaac agaaaataat cccgcttgtt tttgttaagc aaatactgtt tgacttcttg 1755121 gattttctct agactgcgaa tcggctgtac aatatgcatc aaaaaactcc ttaaaaaccg 1755181 ttatgtaaca ttttgaggtc tatgttacta ttatagctga aaaacgttga atgtcaaagt 1755241 gcggcggcgt ttatgtaaca taatatacat agtgttacat aagcttttaa aaaagcttct 1755301 tccaaccttc accctataaa ataagcttta aagcctctta taaagctttt aacctcttgg 1755361 atacttatcc ccctactaat catcaaaaaa cctcttaaaa tgaaatctga cactcccaat 1755421 tttctggagc ttccgcaaaa atatacaaaa aaagacacaa tttcaaattg tgtcctaatc 1755481 ctcatccttt acatcaatat cttccgggat cggttcattt aatatttcct gcacaagtgc 1755541 tttgtaattc tccagctgtt cgagatgcgt tttgaactgt tccttataaa tcaaaaattg 1755601 ctccccgtca tgaacggctc tgattttccc ttcgagcacc aagcttttaa tataatcctc 1755661 tgaaagattt gtatattctg ctgtttcttc aatcgttaaa tacatatagc agtcccttct 1755721 taatccgtat gctgattcta atatagcaca tggctcatat caatataatc aattctgcac 1755781 agaaaaacgg cattatgcac tatataatat accatttgtc acttgtgaaa acgctgtaat 1755841 ttttttacgc taagattgta acaatacagc ttcatatagg agggagaaca tgaaaagaac 1755901 gtggaacgtc tgtttaacag ctctgcttag tgttctgtta gtcgctggaa gtgtcccttt 1755961 tcacgcggaa gctaaaaaac cgcccaaaag ctacgatgag tacaaacaag tagatgttgg 1756021 aaaagacggc atggttgcga ccgcacatcc tcttgcttct gaaatcggtg ctgatgtgct 1756081 gaaaaaagga ggaaatgcta ttgacgcagc ggttgccatt caatttgcac tcaatgtaac 1756141 agagccgatg atgtcaggta ttggcggcgg cggttttatg atggtgtatg acggaaaaac 1756201 gaaggataca acgataatcg acagccgtga gcgtgctcca gcaggcgcaa ctcctgatat 1756261 gtttctggac gaaaacggca aagcaattcc tttctctgaa cgtgtaacaa aaggtactgc 1756321 cgttggtgtt ccaggcactc tgaaagggct ggaagaagcc ttggataaat ggggaacccg 1756381 ttcgatgaag caattaatta ccccttctat taaactcgct gaaaaaggct ttccgattga 1756441 ttcggtgttg gcagaggcca tttctgatta tcaggaaaag ctttcacgga ctgccgcaaa 1756501 agatgtattt ttaccaaatg gcgaaccgct taaagaagga gataccctta ttcaaaagga 1756561 tttggctaaa acatttaagc ttattcgctc caaaggcact gacgcttttt ataaaggaaa 1756621 attcgccaag acgctttctg acactgtcca ggatttcggc ggatcaatga cagaaaaaga 1756681 tttagaaaat tacgacatta caattgatga accgatttgg ggagattatc aaggctatca 1756741 aatcgctact actcctcctc caagctccgg cggtattttc ttattgcaaa tgctgaaaat 1756801 ccttgatcat tttaaccttt cacaatacga tgtccgctca tgggaaaaat atcagctgct 1756861 tgctgaaacg atgcatttgt catatgccga ccgtgcgtct tacgcaggtg atcccgaatt 1756921 tgtaaatgtt cctctcaaag gcctgcttca ccccgattat attaaagaac gccagcaatt 1756981 aatcaaccta gatcaagtga ataaaaaacc gaaagccggt gacccttgga aataccaaga 1757041 aggatcagca aactataaac aagttgaaca gccgaaagac aaagtagaag gccaaacaac 1757101 ccactttaca gttgctgacc gttggggaaa tgttgtttct tatacaacaa caatcgaaca 1757161 gctattcgga acgggtatta tggtccctga ttacggtgtt attttaaaca atgaattaac 1757221 ggattttgat gcgataccag gcggagctaa cgaagtacag ccaaacaaac ggcctttaag 1757281 cagcatgacc ccgacgattt tatttaagga tgacaagcct gtcctcacgg ttggatctcc 1757341 tggcggggcc acaattattt catccgtttt gcaaaccatt ctctaccaca ttgaatatgg 1757401 tatggaatta aaagcagctg ttgaagagcc gagaatttac acaaacagca tgagctctta 1757461 ccgttacgaa gacggagttc ctaaagatgt cctcagcaag ctaaacggca tgggccacaa 1757521 attcggcaca agtccggtgg atatcggaaa cgtgcaaagt atatcgatcg accatgaaaa 1757581 cggcaccttt aaaggtgtag ctgattcaag cagaaacggc gcggcgatcg gcattaattt 1757641 aaaacgtaaa taaataaaaa actgtactcg cttcaaatga gtacagtttt ttcatgcaga 1757701 tctttaaaat aaaaactgac aaacgtcttt attctgctaa tgcacgtcta tcttcatctt 1757761 ttcatttcgt ttatctcatc aagaaatgtc tgaaacgcac tcgtaataaa aaagtctttc 1757821 ctgtatataa agacgatctc taagtcttga tatgatggtg gcagctgatg aatccataca 1757881 tttgtacgat gctcggagcc gtcaacagcg gactttggga gcagcgccgt acccatcccg 1757941 gcggaaacac cttttataat agcctccaat gtgccaaact ctatgatttt ttgattgtgt 1758001 atgcctgctt cctctagtaa tcttttgacc ctgtcacgat gagaacagcc agccccaaaa 1758061 aagagcatcg gctgctgaag catgtcttct gccgtccctt ctcgtgatga aatcaaaact 1758121 aattcatcat gggagacatg gagttgtcta actgcagcgt gttcaaccgg cccatataca 1758181 aaagcgccat caactttatg atcaagaacc tgttgaatca aatgatgcgt atcagctgtg 1758241 ttcactgata aatccacttc aggaaaacgc ctgaggaagg atgctgcatg ctcaggcaga 1758301 tgcgttaccg ccattgtttc cagtgatccg atccgcaaag gcccttttgg ttgcctgctc 1758361 attcgggtcg atttttcagc ttggtctaac agcgataata cttgatctgc atattgtaaa 1758421 agattttctc ctgcagcagt cagcttcatt ccccgattcg ttcgatgaaa aagcctgata 1758481 ttcaaatctt cctcaaggtt atgcactctg gctgtcacat tcgactgaac ataattcagc 1758541 atttgggctg ctttcgttat gcttccttcg cgagcaacag cctgaaaaat ctttaaatct 1758601 ccgctttcca cgcgctctca cctgcttgct atgatgaaaa gtgatattgg ctatcatatt 1758661 tgttcatttt actcgaagaa aaccgctatg taaaatatgt aaagatatga aaatacaatt 1758721 aatgaggagg cagacagcat gaaagctgta attcacaacg gaaaagccgg tcttctgggg 1758781 ttatcagttc aggacgttcc atcaacaaag cctggatacg gagaggtaaa ggttaaatta 1758841 aaatctgcag gcctgaatca tcgtgacttg tttcttatga aaaacaaatc tgaacaagat 1758901 cctcacatga tactgggttc tgacggcgcg ggtatcatcg aagagattgg tgaaggcgtg 1758961 aaaaatgtta ctgttcagac agaagtagtc attttcccga cattgaactg ggatttgaca 1759021 gaaaatgttc cacctgtacc tgagattctg ggaggtcctt cggacggaac acttgctgaa 1759081 tatgtgatca ttccttcaca aaatgcaatc aaaaaacctg cttatttatc ttgggaagaa 1759141 gcgggcgttt tacctttatc cgctttaact gcatatcggg ctctgtttac aaaggggcaa 1759201 ttaaaaaaag gcgagcatct attgataccc ggcatcggca gcggtgtagc aacctacgct 1759261 ttatttatgg ctaaggcgat tggggcaaca gtaagcgtga cctcccgcag tgaggagaaa 1759321 agaaaaaagg cgctgaaatt aggtgctgat tacgcatttg acagctacag caattgggat 1759381 gagcagttgc agggaaaaaa gatagatgtt gttcttgaca gcataggacc tgccctcttt 1759441 tcggaatact tccgccatgt aaaaccaaat ggccgtattg tcagctttgg ggcaagctca 1759501 ggggataatc tcagttttcc ggtgcgttct ttattctttc ctcaggtcaa tgttttggga 1759561 acctcgatgg gaagcggtga ggaatttcaa gctatgctcg ctttcattga caaacataag 1759621 ctgcggcctg taattgaccg gatatatcct ttagaaaaag catgtgaagc atataaaaga 1759681 atgcaggaag gcagacagtt tggaaacatc gggatcgtaa tggaataaaa aaagaaaccg 1759741 gctggcagcc agaccggttt ctcttatatg ataatcccct ttatttacgg aagaactgaa 1759801 ctccccatca aatatcgatc cacttcacgc gccacttcac ggccttcatt aatcgcccat 1759861 acgattaagc tttgccctct tcttgcatcc cctgcggcga atacaccatc gatatttgtt 1759921 tgataatccc catatgctgc actgattttg ttatttactg aattaacacc gaactgtttc 1759981 aacagcggct gttctgtgcc ttcaaagccg atagcgataa agacaagctg agcaggccat 1760041 actttttccg ttccaggcag ctcgcggaac tcgtattttc catgctcatt tttcactttt 1760101 tccatttgga tggtatgaag ctctttcagc tttccgtttt tatccgcgac catttttgtc 1760161 gtttgaatgg agtattctct cggatctctt ccgaattttg cttctgcttc ctcgtatgca 1760221 tattcaagcg taaagacgtg tggctgttca ggccacatat tgtcattcgt gcgggctggc 1760281 ggaagtttcg ggtgtttgcc gaattggtgc acgcttttgg ctttttgacg cagagcggta 1760341 gccacacagt cagctcctgt atctccgcct ccgattacga tgacatcttt ccctttggca 1760401 tcaatgaatt gcttgtcttt aaaattagaa tctaaatagc tttttgttgc aagtgtgagg 1760461 tagtccattg cgtaatggac tccttttgag tcgcgtcctt cgattaagag gtcccgctgt 1760521 ttttgagcgc ctgtgcataa gatcacagca tcaaattgct cctttagctc atcagctgta 1760581 atgtcaacac cgatttctgt gttcgtgaca aaatcaattc cctcttgcgt cagcaattta 1760641 attcggcgtt ctacaatgcc cttctcaagc ttcatgtttg gaatgccgta tgttaaaagg 1760701 ccgcccgctc tgtctgctcg ttcaaaaaca gtgacggaat gtcccgcttg attcagctgg 1760761 tcagcactcg ccagtccggc tgggcctgac ccgacgatgg ccactttttt gcctgttcgt 1760821 ttttttggaa ttctaggttg aatccagccg ttctcaaatc ctttatcgat aatggtccgc 1760881 tcgatgtttt taattgatac ggccggatct gaaatcgcta aagtgcatga tccttcacaa 1760941 ggagcggggc atacccgccc tgtgaattca ggaaagttgt ttgttttcaa cagacgttcc 1761001 aatgcttcct tccatctgcc ccggtagaca agatcattcc attcaggaat taagttgtaa 1761061 atcggacagc cggatgtaaa tccgttaatg tccgcaccga tctggcaaaa cggtgtaccg 1761121 caatccatac accgcgcccc ttgccgtttc gatgcttctt ctgaaaaagg agcagaatat 1761181 tctttccaat cctttaagcg agtgagaggg tcccgctccg caggtttttc tcgtttgatc 1761241 tccataaatc cagttggttt ccccatgttc ctctcccctt ccttactgta ctaccgcttg 1761301 tttttgtccc gatgctgctg tattctgctt tggcttcgtg ttggcctcaa aagcgaacat 1761361 gatggcttct tcatctgata aacctgcagc tttttgctct tcgatgcttg cgagcatttg 1761421 tttatagttt ttcggaatga ctttgacgaa ttttttcaca ctgtcttccc attgatctag 1761481 cagatcttct gctttttggc tgtttgtata cgcagtatgt ctttcaagca ttgctttgat 1761541 ttgctggatt tctttctcat cctctaatga ttcaaataaa atcatctcaa ggttgcattt 1761601 gcgtttaaac gctttgacat cttcggtcag tacataagcg attccgccgg acatacctgc 1761661 cgcaaagttt ttgcctacat caccgagaac gacaacgctg ccgccagtca tgtattcaca 1761721 gccgtggtcg ccgatgcctt ctacaactac gttcacaccg ctgtttcgaa cggcaaagcg 1761781 ttcaccagca cgcccgttaa tatatgcttc tccgcttgtc gcaccgtaaa aagccacgtt 1761841 gccgataatg acattgtcat ccgaagcaga gttgaatcct tctgatgact tgacgatgat 1761901 ttttccgcca gaaagccctt ttccgacgta atcatttgag tctccgtcca aataaagcgt 1761961 catcccttta ggaacgaaag ctccaaagct ttggccggct gatccggtaa agtgcagctt 1762021 gattgtatct tcaggaagac cttcttctcc gtaacgcttt gagatttcac tgccggttat 1762081 cgttccggct acacgatttg tattattgat ttcaatcgaa atatcagctt cttttccaga 1762141 ttcgatggct tcttgtacgg ccgggagaat tgttgtaata tcaagtgatt gatcaatttt 1762201 atgattttgc ggcgattgga acgtccgcac cccttcaggc tgataaagaa gggtagacaa 1762261 atcaagctgg cttgctttcc agtgctcctt tgcccgttca cttgcatgaa gtacatcagt 1762321 gcggccgatc atttcatcaa atgtcttgaa gcctaacgca gccatgtact cacgaacttc 1762381 ttcggcaatg aacagcatat agttcacaat atggtcagga tctcccatga actttttgcg 1762441 aagctctgga ttttgtgtcg ctacaccgac agggcatgta tccaaatggc aggcacgcat 1762501 catgacacag ccgagtacaa ctaacggagc cgttgcgaaa ccaaattctt cggcgccgag 1762561 caaggcagcc atcacaacgt cgcggcccgt catgagcttt ccatctgttt ctaatacaac 1762621 acggtcacga agtccgttca gcattagtgt ttgatgtgct tctgcaaggc caagctccca 1762681 cggaagccct gtatgtttaa tactggtttt cggagaagcg cctgtacctc cgtcatagcc 1762741 gctgatcaca atgacatctg cagtcgcttt ggcaacacct gcagcgattg ttcctacacc 1762801 tgcttttgac accagcttta cgctgattct tgcgtcacgg ttggcatttt tcaaatcgtg 1762861 gatcagctgg gctaaatcct caatcgaata aatgtcatgg tgtggcggag gtgagattaa 1762921 tccgacacct ggcgttgacc cacggacatc ggcaacccat ggatatacct tgttgccagg 1762981 aagctgcccg ccttcacccg gcttagcacc ttgagccatt ttaatctgca gctcatcagc 1763041 attgacgagg taatggcttt tgacaccaaa ccgtccggat gcaatttgtt tgatcgcact 1763101 tcttctatca tcgccgttct catctggaac aaagcgtttg ggatcttctc cgccttcacc 1763161 gctgttgctt tttcctccaa gacggttcat tgcgattgct aaagcttcgt gcgcttcctt 1763221 actcaaggac ccgaatgaca tcgcacccgt tttaaaacgt ttgacaatcg attcagcgga 1763281 ttcaacctcc tccaacttca aaggcttgcg gtttccgtca aatgcgaaca agttccgcaa 1763341 aaatccgatg cgttcttcat cagccgcttt tgtatactgt ttaaacagat tgtaatcatt 1763401 tctgcggcac gcccattgca aagtatgaat cgttttcgga ttaaacgcat gatgctctcc 1763461 gccatttctc cattggaagt cacttcccgg ttcaagcgtt ttgctgtaat catcctgata 1763521 cgcttcccgg tggcggcgct gtgcctcttc tgcaattgtt tgtaaatcga tgccgcctag 1763581 ctgtgatgca gtacctgaga aatagcggtc gatcacatcg cggctgattc ctaccgcctc 1763641 aaagatttgt gcgcctctgt agctttgcac agttgaaatt cccatcttgg acatcacttt 1763701 tacgacgccc tcagtaatgc tttttccata tttgctaacc gcttcttcat agctgatatc 1763761 caaacggcct tcatcaattt cctgcttgta ggtcgcataa gcgagataag ggttaatcgc 1763821 atctgcgcca taaccgatta acgctgcaaa gtgatgcact tcacgtgctt ctcccgattc 1763881 cacaataatg ctgaccttcg tacgcagccc tttgcggatt aagtgctggt gcagtgcgct 1763941 tactgccaga agcggcggaa ttggtgtcag tcgttcgttc atctttttgt ctgataaaat 1764001 taacaaactt acgccttggc tgatggcttt ctctgcctgt gtgaacatgt cctttaaacc 1764061 gcgttcaaga tcctctgaaa acagcacatc aattttttgg ctttttaaat caggatgaac 1764121 aatcgttttc aatgcgtaaa actgttcatt ggataaaaca ggtgtataca gtttaatccg 1764181 gcgaacattt cgttcacttg gatgaagaag atcgccttcc gcaccgagcc aagtcatcgt 1764241 tgaagtgaca agctgctcac gaatcgcgtc gattggcggg ttcgttactt gtgcaaacag 1764301 ctgtttaaag tagttaaaca gcgattgcgc tcggtcagaa agtacagcaa gcggagcgtc 1764361 attccccatt gaaccaaggg gatctttgcc ttctttaata acaggaatta gatacttttg 1764421 gatatcctca tatgtgtatc cgaatgcctt ctggcgagta agaagatcac taaattgttc 1764481 ttcttctctt gactccggat caggatttac ttgtacaagc tcttcttcaa gccatttttg 1764541 gtacggatac tcagttgcaa tttgtgtttt gacttcctca tcggagataa tacggccttc 1764601 ttccaggtcg attaaaagca ttttcccagg ctcaaggcgg tttttatata aaacgttctc 1764661 ctgttcaact tcaataacgc ctacttcaga tgagaaaata atataatcat cttttgtgac 1764721 ataataacgg gccggacgga gaccgttccg gtcaaggatc gccccgattt gtttaccgtc 1764781 agtaaatgaa atagctgtcg gtccgtccca aggctccatc agggagctat ggtactcgta 1764841 gaacgccctt ttttccttgg acatatgcgt attttccgtc caaggctctg gaatgagcat 1764901 cattgccgta tgtgccggtt tgcgtccagc catcacaaaa aactcaaatg cgttatccaa 1764961 aatggaagag tcactgccat cagcattgag aatcggcaaa atcttgttta agtcctcacc 1765021 gaagctttca gaaacaaatt gctgctcacg tgctctcatc cagttgatat ttccgcgaag 1765081 ggtgttaatt tcaccgttgt gaaccaaata gcggttagga tgcgctcttt cccatgtagg 1765141 gaatgtattg gtactgaagc gtgaatgaac aagcgcaaaa gcagaaacga atgcttcgtc 1765201 ttgcagatca gaataaaatg catcaacctg ttcaggtgtt aaaaggcctt tgtaaacaat 1765261 ggtctggctt gaaagactgg caaaataaaa atcaagacct tccgttactc cccaattttc 1765321 agcctgttta cgaatgacat acaattttcg ttcaaaagat aaattgtcct ttagatcaga 1765381 acttgcgccg ataaatacct gacggacaaa cggacagctt ttttgcgcca ctgttccgat 1765441 ttttccgaca tttacaggta cagttctcca tccaagaacg acttggcctt cttgttcaat 1765501 tagtgcattg atttgctttt caattttttt tctttcatct tccttctgtg agaaaaagac 1765561 cattcctacc ccgtaacgtt ctttttctgg cagattgatg tttttgcact cttttctaaa 1765621 gaaagcatca gggatttgaa ccagtaagcc ggctccgtct cctgtatccg gatcactgcc 1765681 ttgccctcct ctatggtcta gctggcaaag catcttaagt ccttgtttga caatgtcgtg 1765741 agtctgcttg ccctttaagt gtgcatatag gccgattccg catgcatcat gttcaaattc 1765801 aggacggtag agaccttgag cttttggcat ttgattgtac gtcataattc ctctcccccg 1765861 atcaatttcc gataataccg gtcataaaat ctaacaactc tataatcatt gtaggttttc 1765921 aaaacgatat aaacaatata taatttagat caaaagaatc tcaaaatgag atagatggat 1765981 gtgagacaaa catggagctg cgccaactgc gttattttat ggaggtggct gaaagagaac 1766041 acgtttcaga agccgctgat catttgcatg tggcccaatc agcaatcagc agacaaattg 1766101 ccaatcttga agaagaatta aatgtgacct tatttgagcg tgaagggaga aatatcaaac 1766161 tcacgccaat cggaaaagaa tttttaattc atgtgaaaac ggcgatgaaa gccattgatt 1766221 atgcgaaaga gcaaattgat gagtatcttg acccgcatcg cggaacggta aagatcggct 1766281 ttcctacaag cctcgccagc cagcttttgc cgactgtcat ttcagcgttt aaagaagaat 1766341 atccgcacgt cgaatttttg ctgcgccaag gctcctataa gtttctgatt gaagctgtca 1766401 gaaaccgcga tattgatctg gccttattag ggccggtgcc gacgaatttc tctgacataa 1766461 cgggaaaaat attatttact gaaaaaattt acgcgcttgt tccattaaat catccgcttg 1766521 ctaaacaaaa aacggttcat ttaatcgatt tgcgcaacga ccaatttgta ttgttcccgg 1766581 aaggatttgt acttagagag atggcaatcg atacttgcaa acaagcaggc tttgctcctc 1766641 tcgtttccac ggagggtgag gatttggatg cgatcaaagg gttagtgtcc gcaggaatgg 1766701 gcgttaccct tctgcctgaa agtacttttg ctgaaacaac acctcgtttt actgtgaaaa 1766761 ttccaattga gttccctcaa gtaaaacgga ctgtcggaat cattaaaccg aaaaatagag 1766821 agcttgcgcc ttccgcgaat gatttttatg agtttgtcat tcaatttttc tctaagctgg 1766881 agcagtatca ataaaaaaaa tgaacccgag cttctatata gaagcttcgg gtttttttct 1766941 gcaaattaat ttacaggtaa agaaaaatcc acatggcaaa caaatgcttc ttgatcaatt 1767001 agagctctat ttgtcagttc ctttttcttt tccggttctt gaagctgtac agaagagtaa 1767061 ttgacgattc caaggccgat ttccgtccct tttgaatcca tcagccgaac aactgaaccg 1767121 cttttgaatt tccctttaat cttctgtaca ccgtctaggt ataaactcga ttgtccgttt 1767181 gttatttttc gtgaacaatc atctgataaa atcatttcac cttccggacc ggaattaaaa 1767241 gcgatccatt gctccttttg attcaacgga agcgttcctt ctgcttcaaa ataggtgcct 1767301 tccgcctgtt catgaacggc gtggtataaa atatcgccag catctgcctg acctaggaaa 1767361 cctttaatgc cagacgccat tacgatttta aacgcatcaa gcttagagcg catgccgccg 1767421 gtgccaacga tgcttccagt gtcacctgcg catgcttcga tgtcaggtgt tatttcactc 1767481 acccgctgta tctttttcgc ttctggattt gtgcgcggat tgccgtcata taatccgtct 1767541 atatctgata aaatcacaag catatctgca tcaatcaatc ctgcgacttt tgctgcgagc 1767601 gtatcattgt cgccaaactt gagccgattg acggtaactg tgtcattttc gtttatgatc 1767661 gggatgatgc cgcgctcgag cagtacattc attgtattcc tgacattgtt gtatcgatat 1767721 tcatcagaaa aatcgcttct cgtaattaaa atttgggatg cgacatagcc gtgtgccaaa 1767781 aacagctttg aataagcctc cattagcaat ccctggccga ttgaagctga tgcttgtttt 1767841 tctggaagct tctcgggcct ttggataaat ccgagcttcc gatatcccgc cgccactgcg 1767901 cctgaggaaa ccaaaatcac ttcataaccg gcgtctttga gtttgacgac ctggtcgacc 1767961 aacgcttcta attttcgaat gctgatttct ccatgaaggc ttgttaatga actgcttcca 1768021 atcttcacaa cgactctttt catgcttgta tcaggcgtca ctttatcact cctgatagcg 1768081 gcgctgcagt tttttcgata tcttcgctga tttcctttga acgcttagcc gcatgcttta 1768141 ttgcttgaga aatcgcttct ccgccgccgc tctttttcaa ggcttgcagc cccgctgctg 1768201 tcgttccgtt cggtgacgtg atattatctc ttaagatctc aggatgttct cctgtttcca 1768261 tgagcatttt tgcggcacct aaaagtgtct gtgcgccgat gcttcgagat aactgtttat 1768321 cgaggcccgc ttcctcgcct gtcttttcaa tgaattccat taaataataa aaatacgcgg 1768381 gtccgctgcc tgcaattccg gtgaatatat ccatttgatt ttcttggatt gtatagactt 1768441 cgcccatgca tccgagcaat gcttcggcca gcttcttcag gtcttccgac acatatttgc 1768501 caagggcaat agctgttgca gaagcgccaa tcatactgga agtgttgggc atcactctga 1768561 caaccggctg ttcattaagc aatgattgtt caataaaaga ggtagttatg ccggcaagga 1768621 ccgacaatat taattgatgg ggttgaatac gtgattttag tgatgacaga gcgttttcgg 1768681 cgtcttttgg cttcattgcc aaaatgagca catccatgtc ttcaatacat agttggttcg 1768741 gcaaggcgcc tttaatgcca tattgaagtt caagttcagt taatcgctct gtattgctgc 1768801 ggtttgtaac gcagatgttt tgtttcggga ttttgttggc tcgaacgata cctgatatca 1768861 ttccttccgc catagatcct gctcctataa aggctacttt cttttgatca aagatcggta 1768921 acatctcctt tgttcgcttt tttgttcgca ttttcacacg tttaaaatgt taccacgtga 1768981 ggaaatgatg tcaagtttga aggccattat tgatttgtat tgtttctttt cgacaaatat 1769041 gtataatgaa aagcagaaaa cacccggttc acactgctgc gccgggtgtt tgtttctatt 1769101 aaaaattatc tgagagagct ttttcaatca gttttttaca gcgatccagc tctaccttca 1769161 gctgtttttt atatagcttg gcagcttcgt aatctttaaa ttgatagagg acgacttcct 1769221 ggagcttagc cccttctttt tttactttaa tttgttttag tatcccgtca tcaagaagct 1769281 catgcaaaga ccggtatact tctgtatgat ttggtttaaa accaatctct ttaaattcag 1769341 accgaagtac ttcaagcagc tttaacccat agagtctctc ttgctctgtc atcgttatca 1769401 tataaagctt caaaaatgcg cgctgtttca ctaaaaagcc tgttgaactc cttttttctt 1769461 ctttcatcat atgcactcct tcttctgtca ctgacaacac tatgtactaa atattcaatt 1769521 ttcttttatt gttttccttc tttatattaa agactgatag tccagttatt tcatgtttac 1769581 tgattatagg tgtagcggaa aaaataaatt tcgactgaac atttggtaca tagttttctt 1769641 agttctatta tagcctgcat ttactgctat cttcaattta aacgattgcc agggtttaca 1769701 tatctcattt taccggtacg gatttcattc aaataaaaaa acctgtcgaa agacaggttt 1769761 tcatttttaa ggatttgttg accataatcc cgctgttttg atgaaaatac gaggatctaa 1769821 tttcagttgt gccaccatgt actcagcaag atcctcaggc tgcataactt tttcaggatt 1769881 accgtctgtt aagttcaatt cgatagacat atcactagcg acagtgctcg gcgttaacgc 1769941 gctgactctg atattatgtt ttctcacttc ttgcataaga gactctgtta acccgagaac 1770001 ggcaaattta gaagcgctgt aagcacttgt tacagcagct cctctttggc ccgctgtaga 1770061 tgaaatatta atgatgtctc cggctttgcg ttcgatcatt tccggaagca ccgcgcgagt 1770121 gacatggtac acacccatta ggttgacttg aataatattt tcccactcat cagctgacag 1770181 atctaagaaa ccgccaaatt tgctgatgcc ggcattatta atgaggatat cgatatcacc 1770241 gagctgttcc ttcacttgag ctacagcttg gttaacctga tcggcatctt ttacatctgc 1770301 agcagcaaat gcagctttta caccaagcgc tttgacttct tcagccactt tttctacatt 1770361 agcggaagtc cggccaatta acccgatatt cacgccttct ttggcaagcg ccagagcagt 1770421 agcgcggcca attcctctgc ctccgcctgt gattagtgca gttttatgtt gtaaactttg 1770481 caattgaagc accctttctt tgtttacata tgtacgatat cacattataa gtacaataca 1770541 tccaatacgc aaatcaaacg aactgtgtaa atatcatttc ttctgattaa aaaaacggat 1770601 acagggtaat gacataagaa aaggagtgaa catatgatta tagtttatat cagtcttgca 1770661 gtattagcag tttctattat cttcttagga gttaccgtga tccaaaacaa gaaaaaaata 1770721 gaccccgcac taaaggagct ttcctctgtt acgcaggcta tgcaaaaaca aatcgaagga 1770781 ttaaaaacag aaacagagct gctgacgcaa aaacaaaaga agattcagca ggatgtccaa 1770841 ataaaaaaat acacgcttca gcagaccgca gctgaagtga aagaagttcc ccaagcagtc 1770901 aaagaggtgt ggcaggcagg acattttaat agcagataag gatgaatgag atcccgttgt 1770961 tacgatcaga atggacaaat gggatctcat ttttcgagga ggcttacaca tgattataaa 1771021 ccgcagctgc ttaaaagagt tcgcagaaaa agtacatttt cttccctctt cacttacaaa 1771081 gtccgattta cttactgatc catttcgtct ccatcaagaa aacgaacttg gcatctacta 1771141 ttcacctcat aatgaattta tcaatcggga tgcctcgctt gtgattgccg ggatcacgcc 1771201 tggtttttcc cagatgaaga cagcgtacga aacagccgcc gaaagcctgc tgcaaggcgg 1771261 gactcttgag caaatggcag tagacacaaa aatagcagcg ggtttctccg gatcgatgag 1771321 acataacctt attaccatgc tggatttatg cgggctgccg caagcttttg gcattcaaag 1771381 cgccgcaaag ctttttggag aattacggca tatgctccat acaacttccg ttattaaata 1771441 tcctgtcttt atccagcaaa aaaactatac cggatacaaa ccggctatca ctcattctcc 1771501 tatcctaagc acttatgctt ttgggcactt ccctgcagag cttaaccatg tgacgggacc 1771561 agctcttctc attccgttag gaaaagcggc cgaaacagtg tgtgaaacat tgatcagaca 1771621 gcacagcctc cagaatttga tttgccttaa cggctttccc catccatcag gcgcgaacgg 1771681 ccatcgtttg aaacaattca gcaaaaacaa agagcaacta gaaagacaaa ttcgttcctt 1771741 tgctgcattg gttgatttcg ctatagaaaa gaggaaataa aagggatatg ataaacaaaa 1771801 acacaaacgt ggggagtggt tgaatgtttc ctatattaga aacggatcgg cttatactta 1771861 ggcaaatcac agatcaggat gcggaagcca tttttgcttg tttctcaaac gatgaggtga 1771921 cacgctatta tgggcttgaa aacatggaat ctatagaaca ggccatttca atgattcaaa 1771981 cgtttgctgc cctctatcaa gaaaaacgcg gtatacggtg gggaattgaa agacgggaca 1772041 ctaaagaact gatcggaaca attggctttc acgctctggc ccaaaagcat aggcgcgcgg 1772101 aaatcggtta tgaaatcatc ccggagcatt ggcgaaacgg atttgcatca gaagtcattt 1772161 caaaggtcgt atcttacgga ttttctgccc ttggactgtc gcgtattggc gcagttgtat 1772221 ttaccgataa tgaagcatca aatcgtctgc ttctaaaaat ggggtttcaa aaagaaggcg 1772281 ttttaagaca gtacatgtat caaaatggga ctccatatga tacaaatgtg tactctattg 1772341 tgaaaccaag agaatgacgg tattctcttg gtctgtgcca catccctttt cctttaaaaa 1772401 gataaaaagc gcccctcaaa cagggcgctt tctaattaag atgcatattg aggagatgtt 1772461 tcctccttaa ctgctttttc ctcaggtata tgaatacatt ttgtcaagac cgcacttgca 1772521 aggtaaaggg ccgcaaagat ccagacgaca ccttgcgcgc cgacgagacc gatgaacagc 1772581 caagcgagtg cagggccgac aaacgctgat aaacctgcag ctaaattcaa tacagacatg 1772641 gctgcccctt tatcttttcc tgccaccgtc ggcacaattg caccaatcgg cacatagcct 1772701 gccagcaaac cgccccaaat aaagccgatc acgctgacaa ccgctaaact tccgccggag 1772761 aaaacaggtg cgtagtataa taagacggtg aaaatgccgc agccgactcc gccgaaccaa 1772821 ataacagtat ttttccagcc gaatttatcg ccgacaatac cgaagataag gttaaacaca 1772881 atgttcccca ggaaaatcgt tccccaaatt tgcagccaca cattggttga aattccatgc 1772941 tgggccatgt gcatcggcaa aaagactgga aaaccatatg taccaatgct gttgatgatt 1773001 ctgatgattc cgcctgtaag cacgcgcgga tttgtaaata gaatcgtaac cccttttaaa 1773061 agctcctcgg ctgtttctga tctttttctt ttcttctttt caaaacggtc tttattgata 1773121 aacaatgcaa agaatgcacc gagacatacc cagaaaatag agctccaaag cgtattcaaa 1773181 taaccgaacg ctttgatcgc gtagcttgag taccaagcgc cgaacacaaa catgccgagg 1773241 caatatgcaa tccaaaacca gccgacagca gtgctcagtt tgctttgcgg tgttctgtaa 1773301 atgacccatg tcaagaaaga ataagcaaaa agcgggtaac ctaacccttt tacgaagtaa 1773361 gtcacataca tcactggcag gttcagctgt tcaaatccaa atacgataaa agcagctgta 1773421 ccgatcacat aaaacaacag ccccataaac atcgttcgtt ttgcgccaaa tgcttcgaga 1773481 catacacccg aaaaccagga agctatggca agcgcaattc cgtatatact aaaaatggaa 1773541 gcggactgct gaacggtgag cccgttttcg atcaaaaaag gactgagcca gccttgttca 1773601 aggccatctc ccatcataaa caaaacaacc cctaaaaatc cccaggcaag ccgcttcggt 1773661 attcctattt tatccaacat atctgtctcc tccttagatg ctattattca ttaccgtatt 1773721 accttattaa agttgaaaat taaatgattc ctcaaaacag cagaaattcc gtcttaaatt 1773781 aatactttgc tttctgatcc tgaaaaaaag cgctgtgttt gcttccattc ctcatataaa 1773841 gccaattcta tctgacagtc cttcggttcg atcacccgga catttgctga catctcctcc 1773901 gttaattgaa aggtttcatt gcaaatgact gcagcaccga cgacagatgc ctgatgatat 1773961 ccctcttgga catagacctt tttttgaaga agatccgcga tatattgagt gagcgctttg 1774021 ctttggaatc cccctccgca cacccaaaca taatcacgtt caaacggagt aacctctgtt 1774081 aaaatgtcaa agttccattt gattgaaaat gcgatctctt ctagcgctgc acgtacaaaa 1774141 tgtgccctct ttaaatgtgc tgacagcggg gcatcaaaaa gaaaaccgcc tctcgttaac 1774201 gcattctttt cagccgataa ataagagccg agagccgcta cacatgcatg gtcttctttt 1774261 gcaagtgcag aaatctcctc ctccattact tcgtacgttt cattcggata aaaaatctgt 1774321 tttaattttt gataattcaa gccggtaatt cccggattcg tttccacaag ccaatgccct 1774381 tgatccgtat gacagttcaa ccaggcttta tgttttgtgt cgccatgatc ctcagtaatt 1774441 ttggttattg gcgttgttgt ccctgataca atgacaatgt cctcaagtcc agctccggtg 1774501 cttttgacag ccagctgtgt atccccgccc cctgctataa ccttagcatt tattgaaagg 1774561 cctaattcgg atgcatattc atttgctatc gttccaattg ctgttcccgc tcttacaaga 1774621 ggcggaagga tagatggaga aaagccgaaa atgtcgcaca tctcttctga ccaagtgttt 1774681 tgcttcacat caaatagcag ggtttctgtt gcctgtgatg gttcatatgt taatattccg 1774741 ctcagttggt acgtcaccca atcactgatg cttgtaaagc ttgcagtctt ttcccataaa 1774801 gagggctggc gctgttttaa tccataaagc ttgagcgcag aaaaaagtgc agttggcagg 1774861 cggcctgtgc tgctgtatat ctcttcccaa tcgggaatgc ccgcctccca ctctcggccg 1774921 cgattatcga tgttcggcag cccgagaaaa ggattgccgt tttgatcaat caaaacaatc 1774981 ccctgtcttt ggctcgtcga tgtcaaacca atgatgtcaa tatcacacga acgggatagc 1775041 gcacgttttg ccaaattcat cacctgcttc cacagcacct gaggagaaaa ataacggctg 1775101 tccgggtaaa gcgtctctgt ggaatactcg atgtcctccc gttcaactgt tagaacactg 1775161 ccagttacac tcacgaccgc taccctcgca ttgcctgtgc caatatcaaa aacgagatag 1775221 cctttttgtt ttttcattct gttagcctcc tttcttatcc ccctgttttc agtgcgtcct 1775281 tgttatacat tgtctgaata ttaagagttt tttcaccctt ccactttttg agggctttat 1775341 tcagtatcgt cacgtgatga tcctccactt caaatgttgc tccagcgaga tgcggtgttg 1775401 ccagaacatt aggcaatgaa atcaattcat aatctgattc ctctggaggt tcatgataaa 1775461 aaacgtctag tatcgcaccg ctgattttat gttcttttaa tacaaataaa agatcttcac 1775521 ggtttacaac aactgctctt gaagtattaa cgaaaatcgc actctctttc atcagatcaa 1775581 aatattgccg atctatcagt ccgagtgttt cctcagtgcg aggcagatgg acagaaacga 1775641 tatcgctgtc tgaaaacacc gttttaagag atgctttttc atacaacgga tgatcgtctt 1775701 gaatgtatgg atcgtaatat tttatcttac agtcaaacgc agtcagcagt tttgcaatcc 1775761 tttgcccgac tgcgccgaac ccaatcatgc caaccgtttt tcctgttagc tcatttcctt 1775821 taaatttgac ataagcctgc aggtaatcac tgtcccactc tccatccttc agccactgat 1775881 tcgaggcgct ggtatggcgc agaaaggaaa tcacatttcc aataaacatt tcggcaacgg 1775941 cttgtgcatt ccgccctggt gtataaaaaa caggtatgcc cctttttgag gcagctgcca 1776001 catccacatt tgagggcatt cccctgcaaa caccgacaaa tgaaagttcg ggaacagaag 1776061 caaatacgct gtctgttacc tgatcaagtt cagtaatcaa gcctgtcgca tttgttgctt 1776121 ttagcagctg aatgagttca tcctcccgat atgccctacc ttgttccttc caagattgat 1776181 aagcaactga gccaaacaag ttttcaagct cttttcgtcc ttcttcgttg tacggtgctg 1776241 taaccaaaac cgtcatgctg caaaacatcc ttttcatcgt atttttcata aaaaaaatct 1776301 ctttccgaag atggaaagag attcatatat aggcgcgctc tgttacaggc agacgccggt 1776361 ataaaccttg ctttcctatc tttcaagcta gcgcttgctg gaattggcac aataatgttg 1776421 ccgaggtttc atagggccag tccctccacc tctctggata gaaaatattg agtatgtaat 1776481 tttcagaatg aagaatacgt ttatcataaa gaagactcag attgatgtca atctcttttt 1776541 ttcagaattg acgttatcat cggaaatgtt ataattctta caaaatatct aactagagag 1776601 aggaactggg ccatgagatc ttttgccaca caacaaaacg gcattttcaa atccgtttgc 1776661 tcgctggact gcccggatca gtgcggattg ttaatacata aaaaagacgg gaaaatcgta 1776721 aaagtgcaag gagaccctga tcatcctgtc acagctggaa acatatgcaa caaagtccgg 1776781 aatatgacgg agcgcatcta tgatgaaaag cggctgacta caccgctcaa acgaacaggt 1776841 gcgaaaggcc aagcgatatt tgaaccgatt tcctggaaag aggcaatcga tacgatcacc 1776901 tcccgctgga aacagctgat tgatgaagag ggagctgaaa gcatacttcc ttacagcttt 1776961 tacggaaata tggggaaatt gacagctgaa ggaatggacc gccgcttttt ttaccgcatg 1777021 gggtcaagcc agcttgaacg gacgatttgc agcaaagcgg gatctgaagg ctataaatat 1777081 acaatgggca taagcgcggg aatcgatcct gaggaaaccg ttcatacaaa actatttatt 1777141 ttttggggaa tcaacgcggt cagcacaaat atgcaccaaa ttacgatcgc ccaaaaagcg 1777201 cgaaaaaaag gtgccaaaat tgtcgtgatc gatgtgcata aaaatcaaac aggacgtctt 1777261 gcagattggt ttatcccaat aaaaccggga accgacagtg cacttgctct tggcatcatg 1777321 cacattttat ttaaagaaaa ccttcatgat gaagcatttc tgtccgagta cacggttggc 1777381 tatgaagagc tccgtgaaca cgtgaaacaa tatgatcctg aaaaggtatc gacgatcacc 1777441 ggtgtcagta ccgaagatat ttaccgactg gcaaaaatgt acggggaaac ctccccttct 1777501 tttatcagaa tcggaaacgg accccagcat cacgataacg gggggatgat tgtaaggacg 1777561 attgcctgtc ttccggcgat caccggccaa tggctgcaca cagggggcgg cgcaattaag 1777621 cataacagcg gaattttaga atataacaca aatgccttgc agcggcccga cttattgaaa 1777681 gggcgcaccc cgaggtcgtt taatatgaat cagcttggca gggtgctttt ggaaacagac 1777741 ccgccgattc gctctctatt tatttacgga acgaaccctg ccgtcgtcgc gcccgaagca 1777801 aacaaagtca gacagggctt gctgcgggaa gacttgttta ctgtggttca tgatttgttt 1777861 ttaacggaaa cggctgcata tgcggacatt gtactgcctg caacatccgc ttttgaaaat 1777921 actgattttt acacctccta ctggcaccat tacattcagc ttcagcagcc ggtgattgag 1777981 agatatgggg aaagcaagtc taacactgag gttttccgat tactggctga agccatggga 1778041 ttcacagacc aggagcttaa agattcagat gaagtattaa tccgccaggc gcttgaccat 1778101 ccagataatc cgcatttggc agagattgat tacgattcac ttactaagca ttcatttatg 1778161 aaagcgaaac gtgaaaagcc gctgtttccg ggcgaacttc caacgccaag cggaaaaata 1778221 gaattatatt cagaaaaaat gaaacaagac ggcttccctg ctttaccgac atatacacct 1778281 cttgtaaccg ataatgaaca tccgtttatg tatgttccgg ggccaaacca taatttctta 1778341 aactcaacat tttccaataa tgaaaaacac atcaagcttg aaaagacgcc aaagctcttt 1778401 atcaacacaa aagatgctga aaaacacgga atcgttgatg gggcacctgt acgaatttgg 1778461 aacagccggg gagaatgcga gctgaccgct gcagttggag aacaagtgct gccaggtgtc 1778521 gttgtcagcc aaggattatg ggcggatgaa caaggaaaaa aacagcttgt aaacgcgcta 1778581 accccagatc gcttgtccga tatgggcggc ggcgccacct ttttttcagg ccgtgtacag 1778641 attgaaaagg tttgaaaaat aatgaaaccc ggagtatgcc aagcccgtat aacataacat 1778701 cgacataatg gaggcataca catggacgtt tttttaggaa ttggtattgc tttggctgga 1778761 tattttatcg gtgaaggctt aaagcagagg aaccaaacca aaggtaatga acaaaatgat 1778821 atcttcctaa taaaagaacg ggatatttac ttttacattg gacttttttt aggaataaca 1778881 acgactgaag caaaacagtt agctggagac atggcagacc tgccttacat cgaaataaac 1778941 ggaaaaaaat atgtccagaa acatatgtta aaagattgga cattcacatt agttgaaaaa 1779001 catcagggtg aataaaacaa atctgaggag agcgagattc attgtcacgc tctcctctgt 1779061 ttagctgtat ggatcctgcc accaaaactt tgtgctataa gcgctgataa aacgataaac 1779121 caccatctat gttctttcct caaacaactc aagatgcccg ttccacaaca atagttttta 1779181 tattcctttg atgacgtgat gttcttgatg aacgtatgta tcgtaaaaca cttagaaaac 1779241 ctattcggtt tgaatgtgtg ctctcattat gcccccatac tgcgccttta tccgcggagg 1779301 atttttttaa aaaaatatga aacctaaagc ttttagatcc tgaattttta ttgaacctcc 1779361 atatttctcc gattggtaaa aattagccta tacaccggaa gctgtacgtt tataaaggat 1779421 cagagaatcc cataaccagt aaatcactgc agccgcaata cttaacatat aataaaagta 1779481 cgattgcaat gtccatgcta ttgacgcagg ttcattgata acaaaaaaca ggaaagctgc 1779541 gataaaagca accacactgt aaatcaatag gtacatgaca ttgaaagttc tcgctttttt 1779601 ctgcaacttc atttggagcg gaacagcaaa aaggccatac accacaaaac cgtataataa 1779661 agcaattgct gccgtaaaca atgcaattat catatcgcca tacataacga aagaataaaa 1779721 ccctaataac aaaccaaatg taaggctgga tagccctaat gtcattaaat aatatgatgc 1779781 gatttttttc attttttcac cccccttgtt tgatttattc acagtgctgt tagtataaat 1779841 tcacaacctt tgtatttctt ttatcgagat gtcttcccta acgtgctata cgcaatgcgc 1779901 taataaaagg tttcaaaaat gacgttcttt tattagataa tacgctggct gaaaacgcct 1779961 ctcctgattg gccaaagcgc gaatgaaaaa agtgcatgaa tacctgccca acagacagaa 1780021 taagaagagt tgatatttca acacttttcg taaaggggtg aaaccaatga gtaagaaagg 1780081 tattcaaaat tcaagtattg aacaaataag aaatgaccat gagactgaaa cagcttttaa 1780141 agcagatgat cctaaaaaac acggttccga tcctaaaaga acgaaataag ttcttacccc 1780201 cactaaaata tcaataatct ggaggaagta aagtgactca aaaaaacggt gcagacagac 1780261 ctgatgatta taaaagattt tcttcattag acaaggaata tgattttcag caatctatac 1780321 gcagcaatac tgagacagaa agtgtaaaca ctgaaacaca aactcataac aaagaaaaca 1780381 aaaatgacac aacagatgtt gccgggaaat actttgagcc ctcagattat aaaggaagca 1780441 cgcaattaga aaaaggattg gctgaaactc atgaacaggt cagcgatgac tattttgaag 1780501 ggacaatcga tcaaaatttg gactagccat acaaacggaa ctaacttaaa agaagtcagt 1780561 taactctgtt tttagaaaca accacagtaa aagtagccaa cccccaccga ataagatggg 1780621 ggttgcacgt aagtagcctg tttaatattt aaaacgatta atgacggttt gaagttcttc 1780681 tgccaactga gatagagatt ctgcggcata ggagatttcc cccattgaat gaagctgttc 1780741 ctgtgatgaa tttgcaaccg cttctgtatt tgctgacgtt tcttttgtac cagcagccaa 1780801 tgtatgaact gtgtgctgaa tcacttcaac gcctgaagta agctgttgag ttgctgctgc 1780861 aacttcttgt atttgagaag tgacctgttc caccaggttc agtatttcat tgaaatttcc 1780921 tgttgtctct tgagaaagaa caatacctga gctcacattt tcttgaacaa ctttaatatt 1780981 atttaccgtt tctatcgatt cgttttggat ggtcgctacc accgattgga tgtggtttgc 1781041 agatttattt gtttcatccg ccaacttccg aacttcttct gccaccacag caaatccttt 1781101 tccttgctct ccggctctgg ccgcctcgat cgctgcattt agtgccaaca aatttgtctg 1781161 ctctgaaatc gtcgtgataa gcgaagagat atcgctgatt tctgctgtgc tcgctaccaa 1781221 tgtttgcaat ccattgccgg ctgaatctac agatttatca atgaatttca tctggtctaa 1781281 catcttgttg acggacttag agcctatttc agccttgtct ctcatcgaag aagaaagatc 1781341 cgctatgttc cctgtatttg aagcgactga tgatatactg tctaataatt cagtgatgga 1781401 ttctgcgctc ttttctgtca ttgagctttg cttcacattg ctgtcggcag ccatctgcat 1781461 ggctcgtgaa atatgttcag atgttgattt cgattcttcc gcgcttgccg ataattcttc 1781521 agaggaagcg gcgacttgtt cagatgagct gctgatctgc ttcacaattt gagttaatga 1781581 atgagtaaaa gaattaaaag attgggcaag ctggccaaat tcatctttat ttttcacaat 1781641 gacttttttg gttaaatcag cctcgccgtg tgcaatttcc tccagctgct tatttatgct 1781701 tcttagtggc accataatgg actttaacag cattatgctt agaacaatgc ctaatattac 1781761 tgatatccct gtgacaatga taatgagcga ttgactcatt ttcccattgc cctgtatttc 1781821 atcctttaga tcctctacct cttgatccag gcgatcagac agcttattga cagccggagc 1781881 tacgccttct tttcttattg ttctttcttc tccaaaatgg atggtttctg cttttttagg 1781941 atttgaagag taggctgtta ctacttgctg attcaaagct ctatactgag taaaacttgt 1782001 cttaatgtct tcaatattgg attgatactt ctcttcatca atcaagtcat taacccggtc 1782061 aaggctcttt aagacatcgt ctgcttttcc cttcataccc tcgtcgtatt ctttgtctct 1782121 ggtaatcaag aagcctcttt catcatttga taacccggtc aattcatatt ggatgtgttt 1782181 tatctctttt tggaattcca ttttgtcttt aagttcttca ttctttttca cagtagaaga 1782241 aatcataaat actgaggagc ctccaattcc aataattgaa acaactaata ttgatataat 1782301 ccccagcaat tttgttttca ctttcatgtg tcgttttccc tttccgcaca atgtaatggc 1782361 tgaaataaaa tatgttcaag cgcgtttgaa tccaattcgc ttacgctcat gtccataata 1782421 tcgacacgtg ttatcaagtt ttatagtgat attcttatat gaataagcaa attctttacg 1782481 tctctgaact tacagaaaaa ccttaagtaa aatttgcagt cttttgcggt atgtaagtca 1782541 ctcttattcg tttttctaaa aaaggctttt cccacctcaa attggctgaa ccggctgttt 1782601 tctcgaaaat ataatacaat acgcagcata atatgaagga gcgaaactta aatggggatc 1782661 atcaatggta aagaattcat tgaccgattg aataaactag aaaacgaaat atggtatgat 1782721 ggcgaaaaaa taaagggtaa catttctgag catcctgcat ttaaaggaat aatcaaaaca 1782781 aaaagctcac tttatgaatt gcaaacaaag gatgagttaa tacatgaaat gacttattgc 1782841 cttcctggag atcataatcg aatcggcctt tcctatctcc agcctaaaac aaaaaatgat 1782901 ttgaaaaaaa gaaggaccat gattgaacat tgggctagac atactcatgg aatgatgggg 1782961 agaagtccgg attacatgaa tacggttatg atgagctttg cttcgtcagc ggagcttcta 1783021 aaagataaag agaattgctt tcctgaacat atactagata tgtatgaaca agctgctaag 1783081 catgaccttt cctttaccca tacattcatt actccgcaag tgaaccggtc acagtcctat 1783141 tttgggctaa gtgaaaaacc gatatctgct aaagtcattg atagaaccga aaaaggttta 1783201 atgattcatg gcgcacgact gcttgccaca caaggcgggt tgaccgatga aatcttggtt 1783261 ttttcagcgc ctaaattttt ctttgaaaca gatgaagctt atgctttttc aatcccttct 1783321 aatacaaaag gcgtaaaatt catcacaaga gaatcatttg tattaagcga ctcttccttt 1783381 aatcatccct taagctcaag gtatgaagaa atggattcaa ttgtggtttt tgatcatgtg 1783441 ttagtgccgt ggaatcgtgt gtttttttac gataatgtgg aagcagctaa agattttatg 1783501 acaaaaagct cttttcatgc ctttaccttt caccaggttg tcattaggca aatgataaaa 1783561 attgaatttc tattaggtgt tgcacagctt cttgtcgaca ccattaatgt ttccgaatat 1783621 cagcacatcc aagaaaagct ctcagaaatc attgtgggat tggaaacaat caaagccctc 1783681 attgacaaat cggaaaatga tgctcagtta gatgaattcg gctatatgcg cccctgttta 1783741 attcctcttc aagtcatcag tacgatcatt cctaagctat atcctcgatt tactgaaatc 1783801 atacaattaa ttggagctag cggaatggtg acactgccta ccgaaaatgc atttgactca 1783861 gagatacggg aagatcttga ccaatatctt caagcaacca atacaaatgc tgaagaacgt 1783921 gtgaaaattt tccgtttggc atgggattta acaatgagtt cattcggaac tagacaaact 1783981 cactacgaaa gatatttttt cggagatcct attcggattt caagcaggct gtataccagt 1784041 tatccaaagc aggagcagtt gaacatgatt aaaacatttt tacatgcaga tacagaacat 1784101 tgaaaaaaca gcgggaaaag atccgctgtt tcgtattttt tattcaggaa actgaacatg 1784161 gcccggtact gtataggctt tggacgttcc gctttcaggc agctttggaa tggtgtcttt 1784221 cacaactttt ccgcggatgt cagtcattct gactttgaga gagccagtac ctaaattcgt 1784281 actcacaaaa tggttatagt ccattttctc catgttgatc cacttaccat ccttttcata 1784341 ttccattttc ataacaggat acttgtgatt tctgacttgg attgctgccc accacctgct 1784401 gctgccttct ttgatccggt acgtgaaatt gccggtgatt ggggctttga caacacgcca 1784461 tttaatattg atttttccgt ctttcatatt gccgatttta cggaaggcat taggtgacag 1784521 atcaagagct ccccgagcgc cttcgggata aagatcagta acatatacgg ttgttttccc 1784581 ttttggccct tcaacttcca aataagagcc ggcaagtgcc gcttttactc ctccgtaatt 1784641 gagatccgcc ggatttattg cagtaatctc catatcggaa ggaatgggat ccagcaggaa 1784701 agctcctcct gaatagcctg accctgtata cgttgcataa ccttcatgca ggtcgtcata 1784761 tgctgccgaa gcttgcgggg aaaaacagaa gatcgtcaac aaaaccatac caacaaatgc 1784821 actcatgatc tttttcatat ttggtcctcc tcaaaccaga cttcaaatga gaatcattat 1784881 cattataaga ctcaatccat ctggtttgaa agaggaaata gattcatagt tgattttaag 1784941 gcaaattcac tatcattcat atatcaaatg taggtactta tgaaaaagcc aatacaaatg 1785001 aacgaatgtg cacttcagcc gaatgtctta tttttccctc tcaaaattcg catttcaata 1785061 acgaaatgaa acaggctgtt ggcctgataa cagctataca ggaaaagcta tttttccccg 1785121 ctcagtttca acttagctgt catcatgatg ccaaagatca gcacaatcgg aacccaaata 1785181 atgaagtgat aaaaatcagg ctcagccaga gcaacaataa tagcccctac acaatacaaa 1785241 ataatagcca gtgctcttaa cacagtatct cttaagaaag tcttcttttg cttcttaaaa 1785301 aacaaacggc cggatatatc ctctaaaaga gaagccaaag tgccggtcaa cacagttgaa 1785361 gaaatacctg caatccccag tttttttgct gctgtagttt gaatccccat agaaatgctc 1785421 atgagtataa ttagaatgtg cacaggaaca aatgcccggt aaaaagaaag acaagcaaag 1785481 acaaacaaaa tgaatgcttc aagtgcgagg gcttttgtca cagcagaagg ccaaagggta 1785541 ttttccgcct ttccgaccat caatgtagca atgatcacgc cgcatataaa tccgattagc 1785601 gcagtcaagg aattaaaaac agtgacctga atggatttgc cgatagctaa ccccaataat 1785661 acaatgtttc cagtcatatt agctgtgaac acatgtccca ggcttaaata cccgattaca 1785721 tccacgattc cagctgttaa acataaaagt gatagcaagg tgtttcgata agctgctgca 1785781 gtcaacggtg tatcaatcct ttcttctatt tcaattgtta gtatgtcttt tggcgcaatc 1785841 tctatttttt aagtaaccca acattaatta ggaagataga acctattatt cctttccatt 1785901 aactgtaata ataatccccg caaggaaatg attaaaattg aaaggaagca tattgtgatg 1785961 aaacgacttt gtttatggtt caccgtcttt agcttgtttt tggttctctt gcctggaaaa 1786021 gcattaggtg cagtcgattt tccgaatacc tcaacaaatg gccttttagg ttttgccgga 1786081 aatgccaaaa atgaaaaagg catctctaaa acgggcacaa cgggtggaaa aaacgggcag 1786141 attgtttaca ttcaaagcgt aaatgattta aaaacccatc taggaggatc cactccgaaa 1786201 attttagtgc ttcaaaatga tctttccgca tctgcgaaaa caacagttac cattggctca 1786261 aataaaacac tcgtgggctc ttacgcgaaa aaaacgctga aaaatattta tttaacaact 1786321 tcatcagctt ttggaaatgt catttttcaa aatttaacgt ttgaacacag tccgcagatt 1786381 aacggaaata atgatatcca gctttattta gattccggta tgaactattg gattgatcac 1786441 gtcacattct caggtcatag ctataatgca agcggaagcg atttggacaa actcgtgtat 1786501 atcggaaaat ccgcagatta tatcacgatc agcaactcaa aatttgcgaa tcataaatac 1786561 ggtttgattt taggataccc ggatgattct cagcatcaat atgacggcta cccccacatg 1786621 acaatcgcca ataattattt tgagaacttg tatgttagag gcccaggtct gatgagatac 1786681 ggttactttc atgttaaaaa caattacagc aataatttta accaggcgat tacaattgct 1786741 acaaaagcaa aaatatattc cgaatataat tactttggga aaggcagtga aaaaggcggc 1786801 atccttgacg acaagggcac tggttatttc aaagacatag gcagctatcc atcactcaac 1786861 aagcaaacct ctccgctgac ttcttggaat cctgggtcaa actatagcta tcgtgtccaa 1786921 acgccggaat atacaaaaga atttgtcacg aaatatgccg gatcacaaag tacaactctg 1786981 gtatttggct actgatataa aagaggccct gcgttaaaaa cgctgtgcct ctttttatac 1787041 tataggctat ttttaagcga tccttgtaat tccatcaaga tccagcgtcg gtcaaactaa 1787101 aaagcatatg ttcttttcca caataacttc ttaactggct ttcttattat accagtttat 1787161 cgcaagtgaa aagaaatcat tgttctgaac ctgtattaaa tgaacgatcg tcccacaaac 1787221 tacttaaaaa cccctaaaaa ggatgatgga tatgtgcggc aggtttactt tgtactctgc 1787281 atttgatgat attattgacc agtttgacat cgatcaattt tttcctaaag gtgaatacca 1787341 gccaagctat aatgtcgcac catcacaaaa catccttgca atcatcaatg atggatcaaa 1787401 taatcgctta ggcaagctta gatggggact tattccacct tgggcaaaag atgaaaagat 1787461 cggttataaa atgatcaatg ctcgagccga aacaattacc gagaaaccgg cctttcgaag 1787521 accgcttgtc agcaaacgct gcatcatacc agcagacagt ttttatgaat ggaaacggct 1787581 tgattccaaa accaaaatcc caatgcggat caaattgaaa tcatctgctc tttttgcgtt 1787641 tgctggctta tatgaaaagt ggagcacaca tcaaggatac cctctttata cctgcaccat 1787701 cataacaact gagcctaatg agttcatgaa agatatacac gaccgaatgc cggttatatt 1787761 ggcccatgat catgaaaagg agtggcttaa ccccaaaaat acaagccctg attatctgca 1787821 aagtttgctg ctgccttatg atgctgatga catggaagca taccaggttt catcattagt 1787881 aaattcaccc aaaaataatt cagctgagct tcttgatgca gaaaatcata tgtagtgatt 1787941 gaaaaaattc tctagcaaga acttgtcaaa tagctttgtt ccttaggtgc caatccctct 1788001 agtaattatg aatatttagt acatagatca attagttatc tttagcatca gtttgaaata 1788061 attttattat gtaaacttaa ataagcaatg ttattccttt catataaaat agtttacatt 1788121 tttataaaat cgcttcactt ttctattttg tcagcaaaaa aactgaacca cattaaactt 1788181 atgaaacctg ccgcacctgt ggattgcaaa tatgatataa gcccatagag gtaaatccat 1788241 acactttccc tcctaagaat taaatgaaat ttctttcatc ttacatgaag gtcttctttc 1788301 ttttgtttat ccagtgtaat acttaataat atgttgatga atgcagctgg aaaatatata 1788361 aatcccactc caagaatgcc tagtatcgta cttaaactta ctatgtaatt ctttgtcatc 1788421 gtttgactgt caatcaatat tagaagtgaa atcaatccag ctaaaacacc tataaaccaa 1788481 gcatcgccaa cagcataaga atcatccagc atccctaacc atcgccccaa tatagagctc 1788541 ccaatggcag tcaaactgga taaaaatatg agtgctttca tttcttctcc tcctttaaag 1788601 ccaatcaaac tggtagaaat cggccattga atccccatta tcgaatggtt accatttcat 1788661 ttccacatta acattttaaa gctcattaca atacgattca agcagaaaaa ccctacataa 1788721 cgtatatata gggatttaat aaaacacagg ccaaaattca gctctatcta ctttaaaaag 1788781 atatgaaggg cagctgtgtg atctgttacg tctttacgta ccgggatatt tcacaacagg 1788841 cactttcttc ttgcgcagag aatcaagcat gactgatcca gcattcaagt tgctttgtac 1788901 taattcttta ggcgtcaatg ccatccactg attgagtgac acatctgcat agcggttact 1788961 tttgaacatt tctaaaaacc ataatgtttc tgtaccagtg ttttgtatat agtgtccggc 1789021 attagaaggc acgtatccaa cgtcgcctgc tctataatca aatgtgcggg cagtcccatt 1789081 tccgataaat accgtcattc gtccctgtcc tgttagataa tattgccact catcgctatt 1789141 gggatgccaa tgaagctctc tcatcgcgcc aggctcaatc tgaacaagtg cagcggctat 1789201 cgtttttgaa attgggaagt tagaagaatc cacaattcgt acactccccc ctggcatttg 1789261 aattgggggt tgatttaaca gctcgtgttt aaaggtcatg gggacttttc catatggtga 1789321 ctgaatgtct tcactggcga ctgatcccgg cacattccct tggtagatat agacttgctc 1789381 agacggaaga gagttgaaag cattctccgg gacaccgaaa tttgcagaca gaacatcttt 1789441 tggtgtgtgt gcaagccaat ctgaaatggt taacgttgaa aactcagaaa agttcccatc 1789501 atcgaaaacg agcagaaact cgcagtgttc caatccctgt atggaatgcg gaattcctgc 1789561 cgggaagtac caaaggtcgc cgggaccaac atcagcaatg aaatttcgtc cgtcttggtc 1789621 aacagcggtg atacgtgccc gtcccaaaag catataagcc cactccgctt gcttatgcca 1789681 atgaagctcg cggacgcctc ccgcagttaa gctcatgttt acacctgcaa tcgcagtcga 1789741 aatcggaagc tgtcttacgg tgatttctct tgaccagccg ccgtgatcta atttcatggg 1789801 agcgtctgag aatgaaaatc tcaagttagg aatcataccc tcatctgtaa caggcggaac 1789861 aaatatattc ggattttgaa tatcccgtat tatatttcgc gggcctgtat caatagctcc 1789921 agctccatca cttcgaatag gctgcggcac gtttctgtct tcatgattga ttggttgttg 1789981 ttccaacagc atgcacctcg ttttagaaat gaacaagatt ttatttcagc ctatgcagaa 1790041 tcttagattg ctgtgcctag gaatccgcaa ataaaaaagt gaccaccaat gtgatcacaa 1790101 atacatcaaa taaactattt tttataccat ggcttcttat gtaatttgat tgcttctgtc 1790161 tgttttttct ggcctgtcct ccactccact tttactaata catcatgacc tatcacttca 1790221 tcttcaggca tataatcaaa ggtggaaata tggtcctcca tgcgtccccc acccggcatt 1790281 tcatcacctg tgtactccga taagtcgtac tcatctacgt tatcatcttg atacttttcg 1790341 ccatctacat acagagtaat tctttcaaca acagtccact tttcttcctt cttactcccc 1790401 tgccaatata gatttagaaa ataattgggt ccaattgaag ttttgtctga tttttcaagg 1790461 ttagacatcc acagtccgct tttcccgctg ccctcatatt tcactttgtt ccctgacacc 1790521 attacaaata atgtgatgat gcagatgatc aagaatccag caatgatcaa tagccatttc 1790581 ttaatattgt tcttttttct catgtttttc ctcactttcc taacttttta gtaggaaaat 1790641 acgatcaaaa tgttaccgaa aagaaaataa gaaagggcta atgatctaac agatgactgt 1790701 ctaaactttt gacttaaatt aaagtgcttt ctaaagacaa gattaaaacg tataacagct 1790761 cttaaatgca ttttttgttt cattgagtca agaaccttaa aatggctttt tattattaaa 1790821 aatcaagcta gtgtattaag taacttttca aatttattta tactcatgat ctcgtgagtc 1790881 acaaatctcc catcaaaaaa aacgctaaaa gttgtccaaa tagctggtga cttttgtgcc 1790941 tcttctttcg atgataactg aattgactga aattgaaccc ctttcttttc agtcaattcc 1791001 cgcaaatcat ttatcatgcc cactgcaaac ggacactgag ctgtatagta tatcgtaatc 1791061 cccttttcat tgatagaatc acttttcacc tggctcttaa atgcaggaga atctgcaagg 1791121 ccattccaag tcaaagccat taattgaaaa taaggggcag cttcatcttg tagagtaaac 1791181 cccatatgct caaagaaatg cttatcactt aaatagggca gttttttctt gcctgcgata 1791241 tggataatgc catccatgcc gcacgctttc gcatctgcta tacatttgtc caacaatcgt 1791301 ttcgcatgac cgttattttt atatctgcca gacacccaca gacaattaat gtacataaaa 1791361 ttaggcgcat tgataggcac ccatgcctca ttcgcaggta ggtattcaat aaagactttt 1791421 gcccgttcat gtaagcgata gaacaccaat ccttcatcca ttcgagcttt gagccatctc 1791481 ttcttttcat taactgcatg ctcatattgt ttcgtgctta atgcacagca aatatgattg 1791541 tcttcaatat tgtcctttgt gatttcaatg tagcacatct cctctttccc ccctttaaca 1791601 taattacatg gaattcaact tcacacttta catgcctaat agaataaata cccgttccaa 1791661 cttaaatact ttttcttttc cattttgcca attaactgta aaacccttct tttattcaga 1791721 tattatcttg attcctatat cacccatttc aaatccaaag tgtgttcatc tttgaggatt 1791781 agatgcactg cttatgctat aaatacagta cacgaagttt tttatttgaa gtaatatttg 1791841 ttacgggaca gcaatagtaa ataagtgata aaaggggaat taaacttggt ggaaaaatgt 1791901 tattcttgtt taatttgcgg atacaaagga ttaattcaaa atcctttgta taaaggcgag 1791961 tatcaaaaaa cgtttgacat ttgtccatgt tgcggttttg aatttggcta cagtgaggat 1792021 catgatgtga ggttaggttt tattgtaact cctgatcatt taattgaggc tgcatttcaa 1792081 ttgtatcgca aacaatggct tgagagcggg atggtaattg ctcatccgga agatattcca 1792141 gaagaattga aaaatggcaa ttgcttaaaa tttgaagttt tgttgaaaca attgaaaaaa 1792201 ctaaatcttg acatagaaaa ttttgaaatt agcggttttt aatgatgaaa caggttgcac 1792261 ttgtttaggt ttcactgtca ttatcagtaa aatgttaagt tgaaatgcgc aatcagtcac 1792321 aaagtctcta ttcgtattca ataaagactt tgtgatcatc gacaaacatt tcactcccat 1792381 cggataaagt atccaaaagg cctcctctgg ttcttctcta tagtcattaa tcacagtcac 1792441 tttgacattt gactcagcta tgattggttt tccaacaatt tttcgttttt tcctcaggca 1792501 aagtaagaga tcgaatcatc aaagccattc catctttact gtctaattaa cgccatcttc 1792561 agtgaattta aaggtctgtt ttaaattgcg tccttcttgc cccttctgtg tccaaattat 1792621 aacaacctct aattcagagg ccttatctgc cagcataaaa tgattgaact tcagcggtga 1792681 gccatcattt aaactttcag ctaacatttt agaatcttct tttggtttga cacaattttc 1792741 atcgggacat ccaaaaagcg aaaaccttgt gattgaatta gggtcatttc tatacaattg 1792801 cacatccact gtagctgctt tttcccctat atttttgact tccaaggaat atacttgata 1792861 ttctccttta tgaggtctcg taaattcctt tacatttttt gcttcactta cttttactga 1792921 ccactggtct gttttttgtg taataggcaa caccgtaaaa gtcagggcat gcgcttttga 1792981 ttggcaaaac gtaaatccaa ctgctgtaaa aacaattaca gaaaataata cccttttcac 1793041 ttcatttatc cctccttcct ttcactggcc gctccttaaa gaattgattt tgagcaatct 1793101 acaagctctc ttaaccaaaa ccttacctga ggttttgtct ttactgctct gcatttattt 1793161 ctttcggtat ccgagaagga gctttgggga tttttctcaa tctgctgtta atcacatcag 1793221 aagagtatag cgtaataatc atacttcccc catacctttt tgcccgaatt aagattggtt 1793281 ggttatattg gttttgaaag cgaaagtcag gacctcccca gcttaccgtc gcatcccgtc 1793341 cgggcggtac atatggtaca cttctagtat gagaatagcg ctgaacgatc tgcagtcctg 1793401 cacgatctac tgcattaaat agagttgagg acacctgaca aattcctcct cctacacctt 1793461 cagacaactc cccttttaca ataatgggtg cacttttata tcctttgttc cgagttctca 1793521 ttcccacaac ttggttaaac gaaaacgtct cattagggaa aacaacgtga ttgtcgattg 1793581 cttttgcaga aagagaaata ttgtgtgaac ggcttttatt gcttgagtta aaatacgtca 1793641 cgtactgacc aagctgctgc gtactgatgt gagctagcag ctcgctgtca actttcggat 1793701 aaatgttcat ttccggcact tctatcttgg agggaccttg cccataaaaa tacgcataaa 1793761 acttttccat aaacgcctgt tgatacagtt tgtagccaac cctgcccggg acgatgcttc 1793821 catgatcgtt aaggacagca tttatcggct cacggtacac tttctgatca agctgtttga 1793881 tgaatttact gtatttttca tagtcaacca ttggagtgcc gggaagaggc attgtaaagt 1793941 cttcacggtt aacagtggca atcgtccgtc cttgctgtgt gaccgttaaa ctgtcctgcg 1794001 gctcactcgg ctgagccaat aaaaaaagac cagtgatcaa aatttgtatc ataagtcggt 1794061 ttacctccca atcattagta tgaacagccg cttatccttt gatgtatttc ttcccatcgt 1794121 ttgtttgaat ctttagacgt tgataaaaac cttcataaaa gagcttagct ttatgttcac 1794181 accgatccct gagctcactg aggcacacgg ttcattcagt cggcaagttt gaagtagttc 1794241 agcatctccc agtgatgagg gatgcttttt tgtcttgtca aaaatgaaaa gggtctccta 1794301 taacaacaaa aaatcaatcc atttcaatat ttttttattg agaaacgata aattttttgt 1794361 tacattcaat tagacaacaa ataaatgagg tgcttgttat gaatcgaatg tcgacaattt 1794421 ttttaaagat agctttggtt cttattggaa ttccaattct tgctttatgc atttttttag 1794481 tgcctaaggt agccaactat tcagcagaat tatttccaaa tatcgcttat ataaaatatc 1794541 tcgttttcat ctatttgtat gtaacggcga taccttttta ctttgctctt tatcaagcgt 1794601 tcaaactttt aagctatatt gacaaaaaca aagctttctc gggtttgtct gtaagagctt 1794661 tgaagaatat aaaatattgc gcagtcacta tcagtatctt ttacgcagca ggcatgcctg 1794721 tcttttatct gatggccgag atagacgacg ccccgggtat cattgtgatc ggattggtta 1794781 ttatttttgc ttcaatggtg attgcggtct ttgctgctgt tcttcaaaaa ctgttaaaag 1794841 aagcgattga tataaaatca gaaaatgact taacggtctg aggtgatgac atggcgatta 1794901 ttatcaacat tgatgtgatg cttgctaaga ggaaaatgag cgtaacagag ctttcagaga 1794961 gagttggcat caccatggct aatctttcga tattaaaaaa cggaaaagca aaggctattc 1795021 gattatcaac tttagaagcg atttgcaagg ctttagaatg tcagcccggg gatatattgg 1795081 aataccgaag tgatgaagac acaggattcg taaagaaaaa atatgaagga tcaacagaaa 1795141 aataaagtga ttggcggtga gcttatggac ataaacttat atccatctag ctgctatact 1795201 aagcgtccct ttcatacacg aagaacacaa ctatggagga ggcatacatc atgagagcca 1795261 taaaacaaat cgtccatttt ggctgggaac aagccctttc atgtttgttt cctgccgtta 1795321 tttttgcctc tttggctatt acgcaaatca tcccactgcc cttcttgccg cggtatgact 1795381 ggctgctcat tatctgcgtt ctcatgcaat tgtggatggt gcgttccggt cttgagacac 1795441 gggatgaatt aaaagtgatc acattattcc accttattgg gcttgctctg gaacttttta 1795501 aagtccatat gggctcctgg tcttatccag aagaaggata ctccaaaata tttggagtac 1795561 ctttgtatag cggctttatg tacgcaagtg tagccagtta tttgtgccag gcatggagaa 1795621 ggcttaaggt tgaactggtt aagtggccgt ctttttttgc agttgttccg cttgccgcag 1795681 cgatttattt gaattttttc acccaccatt tttctataga cattcgatgg tggttatcag 1795741 ggcttgtcat cattgtcttt tggcaaacat gggttacata cgaggtgaat ggagctcgtt 1795801 accgtatgcc gctcgcactt tcttttatac tcatcggatt ttttatatgg atagcggaaa 1795861 atatcgctac gttttttgga gcttggaaat atccaaacca aatcgataca tggagtctcg 1795921 tacaccttgg aaaggtaagt tcatggctct tgctagtgat tgttagcttt cttatagtag 1795981 catcattaaa acaagttaag gagcagagtc ccacaaaggc agagatggat gaatcttttt 1796041 cttagcatac gcatacaagc tcccaaatag agtgaaaagc aacgttcaaa tggttgcttt 1796101 tttcttttat gtaactctgc cggtgagtat tcatcttctt caaatttcat cgcaacacga 1796161 taactgattc agattacaac tgctttcaac actttgacaa actcatgcgc cgccggcgtt 1796221 atctcttcaa atgaatgtgc gatgacgcca atatcgcgtg tgaccctagg aaagatgtcc 1796281 tttttaatca attgatgcgg gacggatgaa agtgtaaagt ttgaaatgat gccgataccc 1796341 aagttatttt tgaccatatt aatcaaggtt tcggcatttt gcacagttaa gttttccttt 1796401 aattcgatgt tgtattgcga aaatgcgttt gacatcgcga tttcatgacc gcctttacaa 1796461 aaaatgaggt catcttgata tgtttcaagg tcgacatgct tttcaagttt taattcgtca 1796521 cgctgcggcg ggatgacggc caccatatag tcgttacaca atagctgatt ttcaaacggt 1796581 tcaaatggag atgctgcgat cccgatatca accgtccgat cttcaaccca tccttttatt 1796641 tggtcagagg ttccttcgat caattctatg cggatcagcg ggtagtttga tctgaatgcc 1796701 gcaatcgcct gtggcatgat atttgttgaa actgcaggaa atgaaccaat tttcaccttc 1796761 ccgtttaaca gcttgttttc ccggttggct acttgatata ttttgctttc aattcccttc 1796821 atttgcctcg ccagcagcaa tatttctttt ccgatgtcag tcagcattaa accatgatgt 1796881 ttatccctga tcaataattt gagctgcagt gagctctcca ggttttttat cgctttactt 1796941 accgccggct gagagatgaa caattctttt gccgcttctg taatatttaa tttctcccca 1797001 acttttacaa atatgtgaag atggttcatg ttcataacca tttggttata cccccaataa 1797061 taaaaatgta tttcagttat acataaatgt aacatatgat agaaaccagc acgatatttt 1797121 aacaagaaag gcggcttcat tatggtaaaa gttatgctgg gaatcatatc tgtcacactt 1797181 atttggggtt atacttgggt tgcgatgaaa gtaggaattc atgacatccc cccgctttta 1797241 ttttcgggtt tgcgcctgtt catcggagca gttcctttat ttctcattct cttcatccaa 1797301 agaaaaaagc tttcaattca aaaagaacat ctcaaaagct atatcatcat gagcctgttg 1797361 atggggctgg gctatatggg gattttgacg tatggaatgc agtttgtcga ttcagggaaa 1797421 acctctgttt tggtatatac aatgcctata tttgttacgg tgatcagcca tttttcatta 1797481 aacgagaaaa tgaatgtgta taaaacgatg ggactggtct gcggcctctt cggactgtta 1797541 tttatatttg gaaaggaaat gctcaatatc gatcaaagcg ctttatttgg ggagctgtgc 1797601 gtacttgtgg cagcgcttag ctggggaatc gcgaatgtgt tcagcaagct acaattcaag 1797661 catatcgata ttattcacat gaatgcctgg caccttatga tgggagccgt catgttattg 1797721 gtgttttcct ttatatttga ggcggtccct tcagccgagt ggacatatca ggcggtgtgg 1797781 tcattgctgt ttaatggctt gctttccacc ggctttacct ttgtcgtatg gttttgggtg 1797841 ctcaatcaaa tccaagcgtc aaaagcatcc atggcattaa tgtttgttcc cgtattggcc 1797901 ctattctttg gatggctgca attgcacgaa cagatcacca tcaatattat cctcggcgca 1797961 ctgctgatat gctgcgggat ttttatgaat acatttacat tttcacgacg gaaagtgtga 1798021 atgatataca tttcccctgt catttgggct tcatgtgaca ggagaagact attacgagaa 1798081 agtcttctag aatcctgacg acagcctatt aaacaatgaa aaaagctaat gtctgcatgt 1798141 agacattagc ttggctggcg tttaggctgg tgagaatcca gatacttttt tattaccatt 1798201 ctggctgatc aaactgaaaa ccgtatagac cttttacttt aacatctccg caatctggat 1798261 cttttgtcaa aatcaaataa tgagtcttat aaggcatcgt ctcaactcga tcagttgcac 1798321 taaaatcaaa atgatccccc gagaagtttt tttcactaac ggttatttca tatcctgaca 1798381 aagtcattcg catgattctt gcgttaattg tacatccttc agtatcgaaa atggtgaatc 1798441 tgtacccaaa gtgagatgtc caatggtttg aatttaggtc atcagacttc ataaaccatt 1798501 tttcattctc tgtcattgta aaactcactt tctcctcatc tttcacgata acggccgaag 1798561 cttcccctac atggatagtc aaagccaaaa gaaatgtaaa agctaacatc aacatctttt 1798621 tcaaaagagt tcctcccgat atcttttact tcaatatatt ggaagggtct tttctgatca 1798681 agacagtctt ctccaaatga atctttagca ccatgaaatg agccttaata agaacagttt 1798741 taacccaaat caacctctat tcgaaataag gcttaccaat ctatattctt tttaaaagtt 1798801 tctgcatttc tttatttagc tcctagacac atataaaaaa tgctcctata agttcaggag 1798861 cactacaaaa aactgctaaa gtgttttcta tcgatttatt gtattcatta gctcaaagaa 1798921 atattcaggc ttttgagtct tatttagctt ataccatgaa cgcaatgtat ctggtgcaaa 1798981 tacatctaat tttttcaata cttctaccgc aaattccaga ggagcaattc ctgatgcagt 1799041 aaccaaattt tcatcagata ctgcaggccc cttttcatag aatgtttctc ctttgtaatt 1799101 agggcagacc atattcatat agtcgaggtc attgcttgtg tgctttctcg aatttaagta 1799161 tccttcattc gcgaggccca aggttgcccc acaaattgca gcaatagtcg tgccgagctt 1799221 taaagcgtcg ccaacttttt tcaagatcgg ctgatgaata tcttctcccc aagtgtttcc 1799281 tccgggtaaa atgataagat cttgactccc aagagtacat tcgtcaagag aaatatctgg 1799341 ttttatgctt aatcctccca acgtagttat catttcttta ttaaccccta ctgtaactac 1799401 ttttaaagat gctgcatctt gtttaaagta tctccctgag tttagttccg caattaaata 1799461 tccatattcc cagtctgaca ttgtgtgaaa tacgtagaga taaacttttc tcgtttgcat 1799521 ccaataacac tccaatcaca attgataaag ctttctaata gatgactttg ctgacagtca 1799581 ttgtcagctt ttttgttgat tctattctta tgcccttgtt ctcccaactt ataaaaatat 1799641 aagatcaatt gattctatgt ttactagcgc aaaggggttt gttacactaa ctgtcatggg 1799701 aaacatttca aaggtaatac aaaatcattt gaatgaggag gcctgatgaa gttgaaaact 1799761 aaagcgtcaa taaaattcgg aatatgtgtt gggcttttat gtttaagcat tactggtttc 1799821 acaccttttt tcaactcaac acatgccgaa gcaaaatcca tagaagacac aaacatggca 1799881 agctgtataa cgaataaaaa atttgttcaa cttgagaaaa aatttgatgc caggcttggt 1799941 gtttatgcaa ttgatatagg ttcaaacaag acaatcgcct atcggccgaa tgaacgattt 1800001 gcttacgcat caacctataa agttctagcc gcagctgctg tcctgaagaa aaactcaatt 1800061 gaaaaactta atgaagtcat ccactacagc aaggacgatc ttgttacata ttctccaatc 1800121 acagagaaac acctagatac aggcatgagc ctaaaagaaa tctcggaagc ggctatccgt 1800181 tacagcgata ataccgctgg gaacatcttg ttgcaacagc ttggcggccc taaaggtttt 1800241 gaaaagtcac tgaaacagat tggggatcat gtaacgaaag ctaaacgatt cgagacggat 1800301 ctaaactctg cgattcctgg tgatattcgt gacaccagca ccgcaaaagc actggcaacc 1800361 gatcttaaag ccttcacttt agataacact ctcacgactg acaaacgcat gatcttaacc 1800421 gattggatgc gaggcaatgc tactggtgac gaactgattc gggcaggcgc tccaatagga 1800481 tgggaagtcg gcgataaatc cggagccgga agttacggga cacgaaacga cattgctatc 1800541 gtttggccgc caaacagagc tcctattgtt gtggcaattc tgtcaaaccg ctttacgaaa 1800601 gatgctaatt atgataatgc tcttatcgct gaggctgcaa aagtcgtcct taacgatctc 1800661 aaataatatg tttagccttt tgccacaaag gaaaagacat tactttttta acttctaccg 1800721 ttcatttttt gatgaacggt tctttcataa gacctctaga atcatatatt taaacaccac 1800781 aaaattaaac attattataa ttaacagcaa gttttcattt tatggaacaa gtaaagtttg 1800841 aatctgacaa gaattaagac taagcaccct aaaatccgtt ttcttttctt ccaagaatat 1800901 actccttagt gcaagccatt ataaagatac aagtgaacat acaatgcaga caactctctt 1800961 aagtctctta ttctgtgacc aatttgtaat actcatgaat atccggactc acttccaata 1801021 tttcgtctcg ttcgaagaca ctaacatatc aaaccacttg aattaacata actgaacttg 1801081 atattggtca ctggcagttt caatgcaata gaacaacatt tgttgtctca gaggttatct 1801141 atatgagaat tcaacaattt ttttataata attcatattt ttgtatcgtt gcacttggtg 1801201 gatttgactc ttttcgtgta tggaaccaca cttttatttt ttcacctctt ttgagatcat 1801261 ctgtgttatc aatctcactt aatcctacaa ttactatgtt atttttaaac ttgttcataa 1801321 gttgtccttc agaaagattg taatcttctt ttcctggagc ttttgtatcg gtaatgagaa 1801381 ttgccctttc attgtcttta agcacgacat agcctactag gctctgcatc tttgtttcgt 1801441 ctccgttttg ttcattttta ttgcagcctg caaggaaaat aatgagcata atgagcacta 1801501 tcaagcttac tccgatttta ggcatctttc ttcctcctct ttaaactcat ctttaaaata 1801561 aacaacagga tatcacccaa cccatctact tctttttgca attcataaca gcagcatact 1801621 cattctccaa ttcctcaacc ttctttttat tctttctcaa atatttgcat gtggtagccc 1801681 tcgatattat ccgcttactc atttttgcgc tttcaaatat attattgaag gccgcttctt 1801741 tctggattcc agcataaata tacttatcct tactgtcgtt tactatcgca acttccatta 1801801 aaatcgagat ttttactttt tttatgatcc attattcact tccaaaataa cttccaatta 1801861 caacataata tatgtataaa ttgtaaatgg agttgatgta attgaagatt aggaaaatct 1801921 tattgagttc tgctttatcc tttggcatgc taatatccgc ggttcccgca ttggctgctg 1801981 gcacttcgtc tgaggttgca gtaaaaaatg aagaatatga ttatgacact atataccgca 1802041 ttagtcctct gccaatggac ttccagccaa caatagaata caacggttat acttatacgc 1802101 ttacacgtca ttattttgat tactcaatcg ggttttacac ggctatttat acaaaagttg 1802161 tttaaactta taaaggagct ttttagctcc tttttctctt gttttaagca aggtatttct 1802221 ttctatgtgg tcccctatca aatacaacat caacattctc cagttctctt tgacacgaac 1802281 aaaatctaaa gtttggtttt aaatgctggt aataaaaaat tcactttaaa gaagtgccgc 1802341 ccgcaaaata cggcttttgt acactacgcc aattttatat tgaaaagcca gacctcctca 1802401 aagaggttcc agcttttctt aatgtgctat cgatcttcgt tagttcaacg ggaactttat 1802461 cattcggtac aaatgcagcc tcccaacttc tagttagggc tgatggcgga atatctgacg 1802521 gttctctaca cacatcagac attagaagat ttcaatgtag ccttctgtac catgaacgcg 1802581 aattcgttgc ccatctttta tcagcttggc agcattttca acgccaacaa ctgcaggtaa 1802641 gccatattca cgggctataa cagctccatg ggtcatcagc cccccaactt cggtgactag 1802701 gccttttatg gatacaaaca atggtgtcca gcttggatcg gtaaaggagg taactaatat 1802761 atctccatct tctaaatccg catcttccat gtttaaaatg acacgcgctc gcccctctat 1802821 aactccggag gaaacaggta gacctacaat cgctccggct gggagatttt ctcgtttata 1802881 ctcacctgta acgatttcac catcagacgt gataacacgt ggtggagata gtttttcata 1802941 taatgtgtac tcgtcttttc gtgtactgat gatttgataa tccagtttat gtgtgcgcac 1803001 gacttcgtga agttcttcaa aagtgagata gtatatatct tctttttcat gaataacgcc 1803061 cgcttctatg agttgttcgg cttctttcag taaagcctgc ttataaacga agtatcgatt 1803121 aaccatgccg tattttggat attccctaaa cccgctgaaa ttccggatga tatctatcgc 1803181 tcgttttgtt tctttggctt tttgttcacc atccggtaat tgcttcaatc gatctaataa 1803241 ctcttgttct ttcttcaaag cttcctgtcg cccttgctca aatttccgat ggccgacatt 1803301 aggctcaaaa tttttaatat tattaagaat cattgggaca agtgtagttg gtttttcgct 1803361 ccatcgagtt cttgtgatat caatctctcc ggtacatcgc attccgtatt tgctgagata 1803421 atcatagatc gcgtctcggg ttttgcttcc gccatcaaac ttagccagtt catccaaaaa 1803481 gttatcatct tttacatgtt gtaagtaatc aattacctct ggataaggac gaatcacatc 1803541 tgcgacgtct aatagcgcaa gacccatttc tgaagtaata ttatggggta cagattgaga 1803601 aagcgtatct gctgcgtttt tttcacctaa ccactcgttc attttttcgt taatccataa 1803661 tgaagcattc atagcagttc gaattagaac cgaacttttt gggttaaata aaatcttctt 1803721 taattcctga atatcttcca gaataaaacg aaataaatct gatcctgatt tcgtttggat 1803781 gttttgtttt aactcttcta tcgatgtttg actgctctca atcaaatcag acacgattgt 1803841 cggatcgttt tcaacttgag ccggcatatc tgcattgcct ctgctgggat ttggtgctgt 1803901 tttatcattt ggtatcgact ttatgaaatc tcgtcgcttt attatggtca taagtgcgtc 1803961 ttttaagagc tgatcgtgct gccccatgcc ttttaagaaa acttctctgc tgtcagggga 1804021 tgccagatga tgtgtgacat caacaaatag ccttccaccg gctttacgca tgggtgcaac 1804081 agtcgtcaac agaaaaaaag acaatcccag tggttttatg ggatccgtca tcatttgttg 1804141 atgaccaaca gaaatataga cgtgattttc ttggtcactc gcttcaggga tggggaataa 1804201 agtagtgatt ggacgactct gtacaatata aaaagtatcg cgggccaaac accattcgat 1804261 atcttgcggc tggccgaaat gagcttcgat ctgtcttcca atgcgtgcca gctgtaaaat 1804321 ttgttcatca gtcagtgttt gagccttttg ctgatcagaa tcgatctgct gtgtttctgt 1804381 tccgccttct tttcgtccgt agatagccat ttttttagtt gctattctct tatcgatgat 1804441 ttgcccatcc tgtactttaa aacaatcggc agataccaag ccagaaacca gtgcttcacc 1804501 aagtccaaaa ccggcatcga tggataacac ctttcggttg gaggtaatcg gatcagcggt 1804561 aaataaaatc cccgaagcct gagggaaaac catcctttga acgataacgg ataaatagac 1804621 ttggctgtgg tcaaatccat tttgcatacg gtaaataacc gcgcgatccg taaataggga 1804681 cgcccagcat ttactgatat gctgcaagat tgcatcgacg ccggtaatat ttaaataggt 1804741 gtcttgttga ccggcaaaag aagcatgtgg taaatcctca gcagtcgcac tagaacgcac 1804801 ggcataggca tgttcctcgc caaactggga gagatattga gccactgctt tcacaacatc 1804861 ggaaggaatg tctacttcca taatgatttg ccgaatcttc cggctgatgt taccaatctg 1804921 atctcggtcc tcaactttta gcatggtcaa ttgatccaac aacacttgta acgtttcgtt 1804981 ttgttcgatg gctttttgat atcctactgt tgtgacacaa aatccttctg gtacttgtat 1805041 accttgaatt tttgataatt cccctaaatg taaccctttt cctccaacga gcgaaagctg 1805101 tgttttttca atttcatgta aaccgagaac caaagaactc attctacatc tccccttcaa 1805161 aaaaaaatat tgacaagagc ttcctagcag gatataataa aattataaga tggatatcta 1805221 taacttttta actagaaagc gcacgtagtg tgattatatc accgtgtctg tttttgtgca 1805281 atataaaaag aacctgggaa atttcaccag gttcttttct taatttccat agctagtcgc 1805341 attaaaaaac ttggtttgag ctgattcaat cctctaagga aatcctaaag ttgggttctt 1805401 tttgaactta cttgctttgt tcgtagagtc cccattcata aattggactt tttgttctta 1805461 acagtcccac ctttaactag tataaagtta tgaggatctg gttaactact agatattttt 1805521 attttgaata aggcttatgt ttgataaaga agggttatgt aaaggtgtct gttgtgagca 1805581 agcgctgact acaaaaaatt gatagcattc tcatttaaat accattctat taacctatag 1805641 ggaaagtttt aaaaccagat ggagaatacc ctacctccag caattccaag gccgttcacc 1805701 tagtagaaaa caacctttaa ccattactaa cgattttaat aatcattgat tataaaactt 1805761 ctcaaggaac gatcagcagc ccgttagcta cccctgatta aggatgatct gttaccacac 1805821 tgttacgtta gaacttccac tactttgata tccttctgtc gccatgactt ggtaagccca 1805881 attactgccc agattcattc catggctctt ccatgcgttc acatgattgc tgaaagtgat 1805941 tgtagcgttg cttccggttg gtctcttcga ctggcgaaca ctccagtact gcgtaaaagt 1806001 agtgcgatcg ccatcaatgg aaggtgcgtt ataacgtgta gttgtatata tgtcatatgt 1806061 acccccatca ctttttacag tacctttata cgttccagta ggtctataag taccccatga 1806121 atccactaca taatattcta tgagaggtga tctcgtccaa ccatataaag ttaaatatcc 1806181 attgccattc ggcgcccaaa ctccggcatt atagtttatc gtcctaaatg gcgaacctgt 1806241 agtccaacct ttaccaacaa caaaatttcc ggtattagac caattaacac tgtaattccc 1806301 gccagaccca ttgacagcgt ttactatacc gcccccatca gtccaatttt gccagtagtc 1806361 tgtgctagct gcagaggcgg ttgccgaaaa caagctaata ctcattaaag ctgccgataa 1806421 tccaactaag aaattctttt taaacttaaa catatgttac ctcctataat attttttccg 1806481 actttgaggt agcactcgta tacatttaaa acattcttaa ttactaacgc caaagctttt 1806541 gatcgtcccc ttcagtataa taccacgaat tcatgagcaa atattaaaag tatttgtaat 1806601 tcaattacaa atacctagaa acacattata agtggtcttc ttccaccata tcctgatccg 1806661 agctcgatgt acatgccttt acggcacaca cgaatgtggc gtgtggtgca tcgcctcaat 1806721 acgcaaagac gtttgcctta ggcaaacgtc tttttttgcg ttatccgatt tttgtgccgt 1806781 ttgggacagg ctgatccggc tgcaaaagga cgacgtcgcc ctggccgggt atgccgccga 1806841 ggaccaagac ttccgattta aatccggcga tccggcgggg cggaaagttc acgactgcta 1806901 tgacttgctt gttgatgaga ccttccggct tgtaacgctt cgtgatttgt gcgctcgatt 1806961 gttttatgcc gatttcagtc ccaaaatcta tcacaagctt gattgccggt actcttgctt 1807021 caggaaattc ttccgctttt acaattgttc ccgttctgat atccaatttc tcaaagtcat 1807081 caataactgc catatcaata actccttttt ctcctattgt aaaggagata tacaatattc 1807141 ttttaactaa agagccatca ttttttatcc gaatataagg tgtttcgata caggcggggc 1807201 ggcattcctg tgcttttcgt gaaccatctt gtaaaagaag aaaggttttg aaagcccagc 1807261 gcctcgctca cgacggtaag agtttcattt ctctccatca gcattctttt tgcttcctca 1807321 aggcgaaggt cggcaatata gttctgcggg gacttccctg tctgtttttt gaaccagctt 1807381 gaatagtaag ctgggtgata atgctcgatt tctgccagct tcttaatcgt cagccgctca 1807441 aataaatggc tgtgaatgta tgcaattgag gcatagctat gggattgaag cttttctttt 1807501 atgtattgta ctagcatatg aagcgagttg gctgttccgg cctttgcttc ctctgtcagc 1807561 aagtacctga tcgaagacca gaaaggatcg agggcagctt caattcctga tcctgcacga 1807621 tactcatcaa ttttcattgc atgaagcgga acatccagta caagacattc atttcttccg 1807681 atagaacgga agcgatgctc gcactgcggc ggaatatata aaaaatgatc cggatttaat 1807741 ttcacctggc gcccctcagt ctcaagatca atactccctt caagcggaaa aagaaattgg 1807801 ctgtacgcgt gcttatgtga atgatatagc cgtgtgtatg tccgtttttc gcaaattatc 1807861 tcttgaagcg agtccattag caaacccctt cctttggtca tcttttaatc cggtaatggt 1807921 gttccgatat aggcgaaaag ccgatttttc catataaaga aactgccgcc agattttctt 1807981 tcatcacttg taaaaacatg cgttccgctc cgttgttttt tgcccattca gtcaacaccc 1808041 tgatcacttg ggttcctgcc ccttttcctc tgtgctcctc agctacaacg atattactaa 1808101 gtccgccata accatcaatg acagaaaccg tgccaagcgc tgtcaggctt tctttgtcat 1808161 acatcttgaa aaaagtttta cacggcggca tgcgttcgaa tatgtgtttg taacctttgt 1808221 gacgctcggg tgaaaaccct tctaattgaa taaattcatc tatccaaaca gatgatggct 1808281 cttgttccca cttgtatgta aatcggctgt tgtcatttgt tcggctcata attgaccggc 1808341 acaacgctgt catctggaag cactcgtcta ccttttcata acggctgtct gccaatgcgt 1808401 catcaagccc tttcggtgat gcgttgctaa tatgaaaaca aacaggtaag cctaaacttt 1808461 gataaaaaag ttcggcctct agctgaaaat ccccttcagg catatccgca gacgtccata 1808521 cgctatttgc ccttttggtt acgccaaaat tcgctctgag aagccatttc cctatgcttt 1808581 tttgaaaata agccggccat gaagctgccg ctaatcgttc aatcttgcga atgtcatcca 1808641 ttgcataatg cctctcccct atgtatactc ccttgatatt atacaatatt cagaaatata 1808701 agacatccat ttatttgttt acataatatt tttattgttt attaataatc ctgacaaaaa 1808761 tgtccgaatt gaaaatgaca ggctttctaa aatgtcctcc tcacgttcaa atgcttcttt 1808821 tgcgattaaa acagtaaagc catgcagcag acttctgagc ccccttgtcg catgaatggc 1808881 agtcttttca cttgcatagc cgttttcaat gagcagcttc gtcacaagac agacaatttg 1808941 gtcagagacg atttccgtcc gtttgtcgtg aaccttaaga agagccgctt cataatatcc 1809001 gggattttca attgcaaaat caacatatgc atgagctaaa gaaagcatcg cggaatctcc 1809061 ctttcgttcg gttacggagt ccgccatttg atcaaaaagc tttgtcagtc ctctgacagc 1809121 aagttctgct ctgatcgctt gcagcccgtt gatatggtta tacaatgacg gggggcgaac 1809181 attcattttt ttagaaagtg cagcaagtga gacaccattt accccttcct gatcggcaat 1809241 ctctgctgca gcgtctacaa tcattttttg ggtcaaacct attctcggtg acatgctcat 1809301 catcctttct ttgctttttg gatcgcctgt ctcatccgct ctgaaggtga tcgcaggaat 1809361 tttccatgtc cgacagcgag acaggaaggc gccttatcgg cgagcaattg tgcacttttg 1809421 atggcctcct ccttattcca tgtggcgaaa gcgggaaaag gaaacgccca ttttatctga 1809481 cctgatacag cgattcctcc gcgcaactga aacgcatctc ctgctattaa agtgccgttt 1809541 cttgtatcaa gaaatgacat gctgcccggt gtatggcccg gtgttggaat ggcaagcaga 1809601 gaaccaattg tttcaccgcc cgtcagcagt tggtgaggct ttgtttgtat gtgtttcgga 1809661 atacctcctt ttataggcgt ctgcggctca tcttgccgca aagatgtgtc accttggagc 1809721 aagaatgaat cccgttccga gatcatgacc tttgcatgcg gaaatgtttg tgccaatgta 1809781 tccagtgatc cgacatggtc cccatgtgca tgagtcagta aaatatgctg aagcggtttt 1809841 ccaagctgat tcacagcttg aataatccct ttatagctgc ctggcagtgc ggcatcaata 1809901 agggtgactt cgttttcttc ctctactaaa tagcaattaa ccggaaacaa tgctggaaaa 1809961 aaagtcagct gccaaaccgt ttggtactga gtaattctca tctttttatt cctcctaaca 1810021 aaaactaatg gtgttagttt tattattaac taacaccatt agtttttcaa gagtttatta 1810081 tttttttatc gctacataaa tgttaacttg tgctcgctgt ggcactgcgg cattttgatc 1810141 atacatctca aagtcacctg taaacgtgcg cagatgccgc ttatcccaag tccaaatttc 1810201 cttccacgtt tcaagcacaa tctcttcaat aggaccgatt ctggaagtga aaacggcgta 1810261 agcggaagcc ggcaaatcaa tattttcata tggtcccgga agaatgtcgt cgtattcctg 1810321 aaacgttccg actgaaaacg tataaaaccc attcgtctct tgttcataat tcgaatataa 1810381 ggcaataatg ctcttgtctt tttcagcctg tgataaaaga gcgctcatat cctgcttcca 1810441 taattgatcc cacagtgccg gaatcctcct ttcttccgtc atttccagtg cgttgcttgt 1810501 ccgttgtgat agtccggcaa atcgtttcag gtctaagtgt gttatatgtg aaaagcccat 1810561 acgatctcct ccttttttta agattataga caaagaaacc tgacagcagt gtgtcaggtt 1810621 tcatatattt tttgcatgtg atgaatggtt tcttttactt tatcccttat atgaagaggc 1810681 tgcagaacct caatatcctt tccgaactgg agcaaaaaac cgatcagcca ttgatcttct 1810741 ggaagtgaaa tcaccgcctg gcagatttca tcttcctcac aacagtgaag gacatcatat 1810801 ccgaaccatt cacctatacg ctgacgtgct gacggctgaa caagaataac caattcagtt 1810861 aaacggtcct tttggtacca actcttatcc catggcaaag tgtccagctg aatgtctttt 1810921 ctgataaatg tctgatgtaa gatggccaga tctttcatcc ggttcagttt aaaaaagcga 1810981 aaatcatttc ttaccaggca gtaggcatat aaataccagt gccccgcctt gcaaaccaat 1811041 gtataaggtt cagtttcccg aagtagtgtt tccccgcttg cgcttgtata tgtaaaagat 1811101 atcgttaaca accgatcgat ggcagcgctg attttctcgc gcagcgtctt ttgatcctca 1811161 gtatggcccc aagccgtcat gtcaataaac catttttctg tttggtgctt aaatgcttga 1811221 gtagattgct caggtataag gtgtttgatt ttttgatagg ctgtgctgtg agaaacgggt 1811281 tcatacatag atgaaacgct ttgcaaagcg gaagcaattg caaacaattc ctcctccttc 1811341 agccactctc tttcaagccg atacgtttcc atgatgccaa ttccgccccc ggaaccctgt 1811401 gaggtcacaa tcggaatacc agccctattg atcgtctcaa tatcacggta aattgttctg 1811461 acagatactt caaacagctc agcaagctct gcagcctgca cttgtttttt gctgatcaat 1811521 aacacaacca tcgctaacaa acgttccagt ttcattctgc gcaccttttc ttcttgtatt 1811581 ttccaacaaa acaatcataa cattttgata aagcttgggc atatctatta tgcggcggaa 1811641 tacacctcgc atatgctatg aaaacagggg tttccccttc ttttttgtgt tcagtattta 1811701 tttcagctac tatttccgac cggataagca tacacttctc aacggagggg atttcacatc 1811761 atgcatctta cacttcagag cgtttatcct gccataatca tcatcttttt tctgtataaa 1811821 aaaattaaaa ggtccatcgg ataccagccg ctgaagcccc gctggctgtt cacccgtatc 1811881 attcttttct cgctgtttgc ttttggactt tcaatcttca gcgccattca ccctttttta 1811941 tatggatatc tcattttggg cattcttggc ggatggctcc ttgtcttttt cgctaagaaa 1812001 aacatctctt ttgaaaaacg cagaggaaag atctattttc ggactcatat ttgggtagag 1812061 gtgattctct taactttatt tctatcaaga tttctgtatc gagtgacgga gctttatctt 1812121 acctcacctg atctaaaccg ccttggatca tacagtcagt caatcggaac ggaccctctg 1812181 acaattggcg tctgttttct gatagccgtt tattatatcg gtttttcttc ttttatcatc 1812241 aagctcagca gaaacgaact tgaacagcac gaatacaata aagaaaaaga catccttgcc 1812301 cgctaacagc gagttaagca aggatgtctt tttcaatcat gctgtgtatg atggatcatt 1812361 tgctgaagaa catctaaaac atgttcatcc tccggagagt aataaatcga tgttccttct 1812421 ctgcgcgatt tgacaagccg gagatttttt aaaaatctaa gctggtggga cacagtggat 1812481 tgcagtaaat tcagcttttc tgcaattccg tttactgcat gctcaccttg ggacaataaa 1812541 tggagaattc tgattcgggt aggatctgaa agcgctttga atgtttgcgc gactagaaac 1812601 agcgtctcct cgtccagatc agcagccgat tgttccgttt ctctaaattc agtcatatgt 1812661 atcacctttc tttattcata gttttatctt ataacaaatg cgcttgagtg caaaccagcc 1812721 tgcttgtatt ccatttcaat ctcatagttt aaatttatgt ttcaaatcag gtttttactt 1812781 ggtctgatat accctcttat gtcataataa aaaaggtcat actgctccaa acattgaggg 1812841 tgaaacacag tgaagaaaaa gagaaaaggc tgtttcgctg ctgcgggttt tatgatgatt 1812901 tttgtctttg tcatcgcctc ttttttattg gtcctgcttt ttttcaaccg ggatttaatc 1812961 aaaaaacttc cgatcgatac gaaaacgatt gttttggaac gtttaaccga ttacaaaccc 1813021 ttggtggaag aagagcttga aagccaagga ctctctaatt atacatcact catattaggc 1813081 atgatgtatc aggagtcaaa aggaaaaggc aatgatccca tgcagtcctc tgaatctctg 1813141 gggttaaaac gcaatgagat aacagaccct caactcagtg ttaaacaagg catcaagcaa 1813201 tttaccctca tgtacaagac cggtaaggaa aaaggcgtgg atttggatac cattattcaa 1813261 agctacaaca tgggggcagg ttacattgat tttgtagctg aacatggagg aacgcatact 1813321 gaggaattgg caaaacaata ctccgagcag caagtcaaaa aaaatcctga tctgtatact 1813381 tgcgggggaa atgcgaaaaa tttccgctat ccgtattgct acggtgatta tacgtatgca 1813441 gaaaaagtaa aagaaaaaac aaaaactgtt gaagaatctt tgcaggttgc aacacttgaa 1813501 accatggaat ccaaggctca tgaataagag tctatcaatt tactgacaaa agcccaaaaa 1813561 tgaatttggg cttttgccat gtttacacgt aaaaaaagcc atactgagta tggcttttaa 1813621 taatacggtg aaatcatcaa atatacaata acgcctgtaa ggcttacata cagccataga 1813681 ggcattgtcc atctcgcaat ttttttatgg cgctccacct gcatgctgaa gcctctgatc 1813741 agcgtaaaca gcgcaagcgg cacaataatt gcagaaaggc agatatgtgt aattaaaata 1813801 aagaaataaa tcgggcgcat aataccttct ccgccataga gcgtgttttc cgcaatcgag 1813861 tggtacgtca catagcaaat caaaaatagt aatgttgttg tgaacgcagc caaaataaag 1813921 cgtttgtgag ctttgatatt tttctgttta atcataatca gcgcggccaa taagaagata 1813981 aacgtaaagc tattgaatat cgcattcagc attggcaaaa tgtgaatatt cgcatggctg 1814041 aactgatcta atttaggcat aaaaaacagc actgcgatta aaccgttaat cagaactgtc 1814101 agcgtaagga caatccccgt gtaatttttc ggtttatttt ctgtttggtt catttggtga 1814161 cctctcctaa tttgtactgg ctatccaaat cgtatgcaaa ttcaaagaag atgtcaacgg 1814221 tttcgattgc ttcgtcagaa attagacaca cttcaaaggc cggaggctat tagccccggc 1814281 ctgttaggtt tacgcctctt ttatcaaatg ttcaatgacc ttatgttcat tttcattcag 1814341 caggttcttt tgaattttcg aatgaatggg tttattcata tgctgatcca agatatcggc 1814401 cgtttcttta tccccggcaa taaccattcg ttcccatctt ttcgcggcag ctttttgatc 1814461 aaggctggca gccagccgct tatacagtct cgattggttc tctgttacat gttccctcat 1814521 ccggttctct tcaaatggtg gcgctttgtc tacagcggaa tggctattct tccaagactc 1814581 attgatcata tcatactcat aacgctccac cgcctcaatt tttcctaaaa cagtttcaat 1814641 aattttcact tcatgctgct gagttaaaat aaacgccgta cttgggtatg tctggcgcaa 1814701 accctttagc tgatccagga cagctgtttc ttcccagtaa aatcttgtat ctacagggac 1814761 ttgaagctta ataggttccc atatgccgct gtcggaaaca aaaaacacga gactgcgggg 1814821 catgtctttt cccattgcat tcaagtattg attcatttta gccctgattc catccagaca 1814881 cttttcctcc tctggatcac tagctgccaa atactctttt aatcggctga atcctgactt 1814941 tagggcaatc ttccattctc ccccctgctg ctctggatct ctcatgtctg tattgagata 1815001 cagagagaga attttatccg gcggttccaa ttggacatac tgtaatttgt taatcaatga 1815061 atcaatcgcc attccgattc ctcctttttc acaggttagt tttctttttc ctctcttaaa 1815121 aacgatcaaa cctgactttc cgctaatttc tagtaataat ggaattgttg tttacaatac 1815181 gcctctcttc taatacaatt ggtaactgtg tttctaagct gttttttgaa aggagtttga 1815241 tcttgtttac tgttaaagaa aaaaatcgtc aagagcttga ggaagaacta aatgatttag 1815301 aatttcaaat ttatcgcatg caggagaata tgaaggattt atctaaagat gccaaagtgc 1815361 ttggtattga tcaatcgaaa catgatgagt ggatgattgt ttcctcgatt gatgatggcc 1815421 aaacatgcaa aattatgcta actgattgta aaacggcata ccgaggaaaa ggctgttttt 1815481 cacttgtagc gtcttacaag gacgatgcca ttcatatagg ggatataaaa ggccctccga 1815541 atcacgggtt tggctccatt tgcatgaaat atttaaaaga tattgcaaga gaccataata 1815601 taccgaaagt caccggagac atcgccaaac gggattggaa tcatgtagac cggctgattc 1815661 acttttatga aaaacatcac ttcaaagtat gtatcgatca tgatacccaa tccggcagca 1815721 ttaagtgggt tgatttgtaa aaaagtctgg aagaaagagc caagatatgc tgtaatggta 1815781 taaaaccatt gatggagggt tctatgtacg cctcaaaact gaaaaaggga gacgaaatcc 1815841 ggatcgtgtc tcccgcgacc agcatgtcta tattatcaaa tgaagcaaaa atccaagcaa 1815901 aaacggcgtt agaacgctta ggttatcggg taaccatcgc tgaacacgca aatgaatgta 1815961 acgaatttga ttcatcctct atcgagtcaa gagtccatga tctgcacgct gccttttttg 1816021 atccaggcgt caaagcgatt ttaacgacac tcggagggtt taattcaaat cagctgctgc 1816081 gttatcttga ttacgagaaa atcaaacgac atccaaaaat tctgtgcggt tattccgata 1816141 taaccgctct ttgcaacgct atttatcaaa aaacgggtct tgttacgtat tcaggtcccc 1816201 acttctcaac atttgcaatg aaaaaaggac tcgattatac agaggagtat tttctttctt 1816261 gctgcgcttc agacgatccg tttgaaattc acccctcaag tgagtggagc gatgatcgct 1816321 ggtttttgga tcaagaaaac aggcgttttt atcctaataa cggccctgtt gtaatccaag 1816381 aaggttatgc ggaaggtact ttaattggcg gaaacttatg cacgcttaat ttgctgcagg 1816441 gaacggagta ttttcccgaa acagaacata ctattttatt gattgaagat gattatatgt 1816501 cagacatcca tatgtttgac cgcgatctgc aatcactcat ccacctcccc gctttttcac 1816561 atgtaaaggc gattttgatc ggcagatttc agaaagcatc aaacgtatca atagatcttg 1816621 taaaagccat gatcgaaaca aaaaaagaat tatccggcat cccgatcatc gcaaatataa 1816681 atgccggaca tacctcgcca attgccacgt tccctatagg aggaacatgc aggattgaag 1816741 ctatttcggg tacatcacga atatggattg ataaacatta atcagcttgt aaattttttt 1816801 acaagctttt ttagcgcaat cggctatgca tgccgcacga gacatgacaa atgtcatata 1816861 ggaggcatga tgtgtgctac tacaaaagac ttctctcatt agcgtatact gaaccgagac 1816921 acacaatgag aggatactta ctatgactga acaaaccatt gcacataaac aaaaacagct 1816981 gacaaagcaa gtcgctgcat ttgctcagcc tgaaacaaaa aacagcctga ttcagctttt 1817041 aaacacgttt atcccattct tcggcctatg gtttcttgct tatctcagcc tcgatgtctc 1817101 ctatcttctt acgttagcat taacggtgat tgccgcaggt tttctgacaa gaatttttat 1817161 catcttccat gactgctgcc atcaatcttt tttcaaacaa aaacgctata accacattct 1817221 cggttttctg acaggtgtcc tgactttatt cccgtatctt caatggcagc acagccattc 1817281 gattcatcat gcaactagca gcaatctgga taaacgcgga acaggagaca tctggatgtt 1817341 aacagtaaac gaatataaag ctgcatccag acgaacaaag cttgcataca gactttatag 1817401 aaacccgttt atcatgttta ttctcggacc gatttatgtt tttctgatca cgaaccgttt 1817461 taacaaaaaa ggcgcaagac gcaaggaacg tgtaaacaca taccttacga atctggcaat 1817521 tgtcgcgttg gctgccgctt gctgtctgat ctttggctgg caatcgtttt tactggtgca 1817581 aggcccgata tttctgattt caggttcaat cggtgtttgg ctgttttatg tgcagcatac 1817641 ctttgaagat tcttattttg aagcggatga aaactggagc tacgttcagg ctgctgttga 1817701 aggcagctca ttttataaac tcccgaaact gcttcaatgg ctaacaggca atattggtta 1817761 ccaccacgtt catcatttga gtccaaaggt gcctaactat aagcttgaag ttgctcatga 1817821 acatcacgaa ccattaaaaa acgtaccgac aatcacctta aaaacaagcc tgcaatcact 1817881 tgcgttccgt ctatgggatg aagataacaa acagtttgtg tcatttcggg ctataaaaca 1817941 tatacctgta agccttccgc ctgattcacc agaaaaacag aagctgcgga agaatgcctg 1818001 atgataaagg aggtcttcta atatactaga aggcttcctt tttattgttg gagggtgcat 1818061 tctggctttc acaatgataa agttacaagt aagatgaaaa gctgaaaatg aggtaagatc 1818121 atgattaaaa atcattttac atttcaaaaa ctaaacggga ttacgcccta tatatggacg 1818181 atatttttca tcctcccctt ctactttata tggaaatcat catctacatt tgttattatt 1818241 gtcggcatca ttttgacgct tttatttttt tcggtatatc gatttgcttt tgtctcaaaa 1818301 ggctggacca tttatttgtg gggattttta ttaattggca tttcaaccgc ctccattact 1818361 ctgttcagtt atatttattt tgctttcttt attgcttatt ttattggaaa cattaaggaa 1818421 cgcgtccctt ttcatatttt atattatgtc catttaataa gcgcggccgt cgcagccaat 1818481 ttcagtctcg tattaaaaaa ggaattcttt ctgacacaaa ttccttttgt cgttattacc 1818541 ctcatcagcg caattttatt gcccttcagt ataaaaagcc gcaaggagcg cgaacgactt 1818601 gaagaaaagc tcgaggatgc aaatgaacgg attgcagaac tggtaaaatt agaagaacgt 1818661 cagcgaattg cccgcgatct ccatgatacg cttgggcaaa agctttctct tattggttta 1818721 aaaagcgact tagcaagaaa attgatatac aaagatcccg aacaagcagc tcgtgaactg 1818781 aaaagtgttc agcaaacagc gcgaacttct ttaaatgaag taagaaaaat cgtttcctct 1818841 atgaagggca tccggctcaa ggatgaattg atcaacatca aacaaattct cgaagcagct 1818901 gacattatgt ttatctatga agaagagaaa tggcccgaga atatctcatt gctgaatgaa 1818961 aacattttga gcatgtgctt aaaggaagct gtcacaaatg tcgtcaaaca cagccaggct 1819021 aaaacttgcc gagttgacat tcagcagctc tggaaggaag ttgtgattac agtgtctgac 1819081 gatggaacat tcaaaggaga agaaaattcc ttttcaaaag gacatggctt actcgggatg 1819141 agagaacggc ttgagtttgc aaacggaagc cttcacatcg ataccgaaaa cgggaccaag 1819201 cttaccatgg caattcctaa taattcaaaa taaacataaa ggatggctta tatgattagt 1819261 atatttattg cagaagatca gcaaatgctg ctgggcgctt taggatcact tctaaacctc 1819321 gaagacgata tggaagtcgt aggcaaaggt acaaccggcc aagatgctgt tgattttgtc 1819381 aaaaaacgcc agcctgatgt atgtattatg gacattgaaa tgcccggaaa aacagggctt 1819441 gaagctgctg aggagctaaa agatacaggc tgcaaaatta tcatcttaac caccttcgcc 1819501 agacccggtt actttcagag agctattaaa gctggcgtta aaggctattt gttaaaagac 1819561 agtccgagtg aagagctggc caacgccatc cgtagcgtca tgaacggaaa acgcatctat 1819621 gcacctgaac tgatggagga cttatacagc gaagctaacc ctcttacaga tagagaaaaa 1819681 gaagtgctcg aacttgtggc tgacggtaaa aacacaaaag aaatcgctca ggaactcagc 1819741 atcaaaagcg ggacggtgcg gaattatatc tcaatgattc tagaaaagct tgaagtgaaa 1819801 aatcgaattg aagccattac ccggtcaaaa gaaaaaggct ggtttaaata aaaaaggatc 1819861 ttggcatctg ccaggatcct ttttgttaac ctgaaattcc cgtttgagaa cctcgtcgca 1819921 accagaatta aattgatcca tatcctcgct cctacgcccg ctgaacgatt gtttggttaa 1819981 cagcccaata aaagactgga ttgaatgata tccctgttaa aatggtcggc cattgcacat 1820041 cagcagaatt tctgatattg attatattgt attttcagta tgacaaagtt gtgccacttc 1820101 gctcccgaag ctgccatgcc caactgcaag agcctaatat cacaataaaa aaccgtctga 1820161 aatcaatccg attccgtaaa tggtatctgc tacatccaac tgcttattat ctgccaaaaa 1820221 caccagctcg tttcgctgat caaagatagt aacaaccagc tataaatgtc atgatgccga 1820281 atgtctctgt aatgtggaat caatctttta acccgagagc ccctgaatcg cacataaaga 1820341 aaaacgggac cactttcttt tatcagcata tgatataaac agctctaagc agaacaaaaa 1820401 aagacacaag ccaaaagctt atgtctttta tcacaatcta tattattagt ttaagacttt 1820461 aacacttaca gttttgacgc cccaattaga agcatcactt ttacttggta caaatacgtc 1820521 gattttattt cctttaatag cgccgccagt gtctgctgct gttgcttccc cgtagccttc 1820581 aacatagact ttagaaccta gcggaattac attaggatca accgcaataa ctttcgcgtt 1820641 cgggttctta tttaagtcaa tgcctgtagc tgtaacgccg gaaatgccgc cgtcgttagc 1820701 agtgtaagca gtagcagtaa ctgttagttc ttttgaagct tcttgattat ttgtatttga 1820761 ttgaacagcc ttctcctctg tgttaacaga agtttctgcc tcagcctttg tttcttgttt 1820821 aggttgctgt tgtacagctt cttgtttagg ttgctctttt tgcacagcct cttgttttgg 1820881 cgcagcttga ggtgcgtttg tttgcgcatt ctcagtagct gtgtttgctg ctgttgcctg 1820941 accttttact gaaagagttg atccagcata gatcatgtca gagcttaagt tattccaaac 1821001 tttcaggttg ttgactgtcg tgccgaattt ttgagcaatc ttagaaagcg tatctcccgc 1821061 tttaattgta tattgcccag tcgtggttgt ttcttctgaa gaaatggtca gtttttctcc 1821121 tgcaatgatt ttatcagaag ttaacttgtt ccattctttt aagtccttta ggttcactcc 1821181 atttttctga gagattcccc agagcgtatc acccttttgc accgtaattt cttttgcaga 1821241 agcgtgagct ccgaatgcag ttgttgaaag tgcagcaact gccacaaagg acataatcgt 1821301 cttcttcata agtaaatcct cccttgttag ctttttattg gcggctaaca ggtgatatcg 1821361 taacacacgt aaatgtcaaa tcaataacaa aaagatatga tttagattac agttccttta 1821421 catgaaggat ttctctctga tggaaagact tgctgaaccc ttgatataat aggcttcgca 1821481 ggtcttttta ttttgaggcg aaacagagaa aataaaatgt gttttttata gaaaaaaaga 1821541 ttgtttttct gtttttttag tctgtcatcc ttgcataagc ctgtatttct tgtaaaaaaa 1821601 gccggccgta ttttgctctt ttttgttctc cgactccttt tatagacaaa agttcatcat 1821661 catttacggg ctgttttcct gacatttctt ttaacgtttg gtcagagaaa acaacaaatg 1821721 gcggaacacc ctgctcagcc gcaatttctt tccgaaccat gcgcaatcgt tcaaatagct 1821781 cgtcattttc agtaatcgct gccgctttta acgcttcttt tctcgctact gataattctc 1821841 ctttcagcac attccttcct ttactgctga caaaaagagt cggaaacgtt ccgtctgaca 1821901 tcctgatgaa gtcgtcagaa ataagaaatt cgataaaatc actgatttcg ccaacggatt 1821961 ggtgttttaa tatcccgtat gttgaaaggt cggaaaagcc gttttcaaga acttttttat 1822021 ttttggagcc ggcaagcacc tgggcaacca tcgtcttgcc aaaccgttct ttcatgcgaa 1822081 tgatacaaga taagaccatt tgcgcctccc gcgtcacgtc atgggccgct cttgtatcgg 1822141 tacagtttcc gcactgtccg cacgcatcag gctccttttc tccgaaatac ataaggataa 1822201 aacgctgcag acaatcttcc gtatgacagt agtcgaccat ttgtctcagc ttttttaaat 1822261 cctgcttttg tttctcttca tgttctgatt gctcaattaa gaagcgctgc accataatat 1822321 cctgcggtga aaacaggaga acacattcac tggcaagacc gtcccgtcca gctcgtcctg 1822381 cctcttgata atagctttcc atatctttcg ggatttgtgc atgcagaaca aatctgatat 1822441 ttgatttatc aatacccatt ccaaaagcag aggttgccac catcacttga agctcatcat 1822501 taagaaatct ttcctgctgc tcttttctca catcatcagc caaacctcca tgataccggc 1822561 ctgccctgac ctgatttcgt ttcaatctct catatatccg atcagcttct tttctggtcg 1822621 ctgtatagac aattcctgct tcatgcctgt tgttttgcac atattcgtct ataaaccgat 1822681 ctttattttc tccttttact actttaaagg ttaaattctc tcgggaaaat ccggtatata 1822741 ccgtgttttc tttttgaata tgcagctgtt tgcaaatatc atcatgaacc tcgggtgtgg 1822801 ctgttgctgt taacgccatg atgacaggct tgtcgtgtaa ttcacggaac aagatttcaa 1822861 tattcctgta gcttggcctg aaatcatggc cccattgaga aatacaatgc gcctcgtcta 1822921 ttgcgaccaa aggaacatct atgccctgca aaatccggat aaactctatg gacgttagtc 1822981 gctctggtgt aatgtaaaaa agcttataag ccccttcttt gagtccgttc agcctctcat 1823041 atatttcctg attggattgt gtgctgttaa tgtaggcggc gttaatcccc gcttcttcta 1823101 acgcatcaac ttgatccttc atcaaggaaa tcaacggtga aatgacgatc gtcgtccctt 1823161 caaacattaa tgccggaatc tgatagcaaa tcgatttgcc gcctcccgtc ggcataatgc 1823221 aggccgtatt ttgcctcgct tccgtcacca agcggatcgc ttcatcttgg ccgctccgaa 1823281 acttctcata accaaaataa tgagccagaa gggattgggc tctatgtaac ataacgtgta 1823341 aacctcgctt ttccttgaat ttctcccatc atatcataaa aaagcggcct tcatttcttt 1823401 cacacaaaaa tggaatattc actataccaa acctttttag ataaaataaa aagccatttc 1823461 cgaaaaggaa atggctttcg ctacgtcttg ccgtatgcaa gtaagaaagt tttaaaccac 1823521 cactcctcaa agtgggtgtt tgcagaaacg ttcctgtcgt cctctgcaat ggaggcatga 1823581 cattccggct tcgatataaa actccctatt acagcttaaa ggttaaaact taattaacaa 1823641 tacgcacaaa gtagcttctt taatatagta caccatcagg cgcttttaat caagaggtca 1823701 gaacaattgt ttagaaaaac tttttccagt gaataaaact gttttttctc caaaatacct 1823761 gacaattcga caaacaaaaa atatattaca ataaaaaaaa tagcctttat tgctaaaagc 1823821 gaatgattat tttcttctat attaatgtgt atatacaaaa agactcctat ttgtaacgat 1823881 aggagtcttg gctttattag aattttgcag caagatcttt tgcttcttgt aaaccttttt 1823941 caacgatttc ttgcgcttga tcaggtgctg cgttatgtcc ttcgatgaca actgtgtgca 1824001 agtcttgaac accccagaaa ccaagaactg ttttcatgaa gtttaatgac atttcaagtg 1824061 cagccattgg tccttctgag tagacaccgc cgcgagcgtt aagaagcgca acttttttgc 1824121 cgcccattaa accgactggt ccttcttgtg tgtatttgaa tgtaacgcct gcgcgagaca 1824181 gataatcaac ataagtatga agcactgctg gcactgtgaa gttccaaagc gggaatgcga 1824241 aaacaacttt gtcagctttt acaaactggt tcagatattt gtcagcaatt gctgcttgtt 1824301 ttttctcatc ttctgtcatt tccattcctt gacctgcttt aaatgttccg ttaatcatat 1824361 ctctgccaag gtaaggaagg ttttccttat gaagatctaa ttcaaccact tcatcattag 1824421 ggttgttttc tttataagca gctaagaaag cttcgtaaag tttagttgaa acgccttctt 1824481 cagctgtacg gtcgcttgat tttacaaata aaactgtaga catttgtatt cctcccggta 1824541 aactttttat atttacttac aaatagtatg ttactttctt ttttacgtaa agtcaatcac 1824601 tttattttga atatgagatt ttttttcaaa aaaaagcaag tacatctaat atcggtgtac 1824661 ttgcttggca tttttacttc gaatcttgtt cacgatccaa gatttcatac gtctgcgagc 1824721 ttttttgatc aattgtttct ttgttggata agtcttttac ctgttcatga aactctcttt 1824781 cataagaagg agcatctgtc tccagatcat cctccacatc agcttgggcc tcaactgtca 1824841 ttcttgcata aggaacagct tcaagtcttt cgtaaggaat ctcttggccg gttttttcac 1824901 acacgccata agttccgtct ttcatctttt gtaatgcacg gttgacctcc tctaacagct 1824961 cccggtcaat ctctttcact gtttggtctg tcatccggtc tgtgacgagc gtcccgtggt 1825021 ctgccatatg gttgtcaacc ccattggaaa gctcccccac ttcttccgtc attgattctg 1825081 tttccttttt ctcgccagac aattcttttt gcatatcgag caatttatga tagagatgct 1825141 gtgtttgttc ttttgtcagt gccatgtata tcctctcctt tctatcctgt ttcccgtttt 1825201 gccttctgtc aaacatggaa acatcgatgg aaagatgagc tactgccttt ttgaacggat 1825261 cgtgaccgct ggcgtcgatg gtgcttcggg ttttcgttgg cactttttgt ccttctcttc 1825321 tggcggtata taataggttg cgcctatatt taatctgccg ctcagttcat caatggtcag 1825381 ctcgccgaat tcaagatgat agtcaacttt ttcgacattc agcgtttcaa tatgtatata 1825441 ggtttcttca gactcttgtt tgctgctttg tttttgtttc tcaatcactg agagtctttc 1825501 ttcacattca cgcagtttgt caagttctgg tttcaagcaa tgcctgatca gcgaccggaa 1825561 catttttttc atgacatcac gaccctttgc atactcctct ttcgtctaca tatataatga 1825621 ggtatatccc atagaaagga gaggttttca tgcttccgac taacatcaat atttctcatc 1825681 tcaagactaa ctcgataggc accggctcat cccttacctt tggttctgcg gagttaagga 1825741 acaggtgctc tgctatcaaa agaaataacg gttttgggga acaaaatgca gatggtattg 1825801 ttatggtcat tccgattgaa tcaattgatg accgtgatgt gtcagatgca ctcagtatga 1825861 aaatcaatca tcaataacaa tggttttcgc ttgaccttcg tctttttgaa tagtgatgta 1825921 taggattccg tctttaaaaa tggcattcat ctttccatga agatgatcgg aaagcggaat 1825981 tttcttttca aaacttccgt atttcccttc tttttggcga aagtcctgtt cattaaaata 1826041 ggaaaagcgc tgccccttca ccactaaata atctccgtac gataatatgt gaacgtcttg 1826101 tttacggtag cctggaagat aaattaaaaa ctgcacttcc gcaacggtat ctacaatatc 1826161 catgctcgga aatgaagcat ctcctttccc tcgctgatct tgctgcgcaa acggaaacgg 1826221 agattggcca tttgtcataa aaggggtttt ttggtcttca tcaaatacct gtttccaaaa 1826281 gtcaccgccg tacatctgct gtgcgaattc catccactgc ttcatctttt cgaaatccat 1826341 ttgaagcccc ctgtcttaac atactttata accgccagca tacaactata gaaaggaggt 1826401 ttgcctgtgg ttcaaccaac tccgtatatc aatattaata ttttcatgct gaaaattaat 1826461 tcctttgaaa atgcttcagc ggttaacgta ggacaaaatt tattggcaga atggcaaaat 1826521 tcagataaaa aaaatcaagg ctacggacag aattttggag atgcgagcgg atttatgggc 1826581 acgagaagcc atgtggatga cagagaccaa attgattctc cggcctcttt tgaaagtgaa 1826641 gcggttaact cctcaatcaa aaggaagtga tgagatgttc ttttcaccct ccgtcgtaaa 1826701 tgtcggcgga tttaaaatca atacgatgga tcgaggttcc tctttaacac tcggtccgta 1826761 tcagcaggtc gattactttt tatcagctaa aataaatcaa gggtttggag aagaaaatgg 1826821 cgactttact cctcttgtcg tgccgatttc aaatgtatta gatgcagatc ttgttgattc 1826881 gaactcagcg aaaaacagtg tggtgtaata agaacagggc gcacatgccc tgttcttgtt 1826941 tttatatata aaaaaagcct aaccattttt tgaacggctg gctcatcaaa tattcagctg 1827001 cacaaatgct ttgtcagcac cgcctgaacc tcgcttaaat cggtgtcttt cgcaaattct 1827061 aattcgaaag ttttgcttct tgtcatcaat aaaagcccag tgtccggatc aaacattccc 1827121 gcttcttgga tggcaaagct ttcaattgtt ttatatggaa gaaatacacg aaccttcttt 1827181 ttagaaaaca ttttattgtc aaagaaaatg atccgcttat ttgtaaagca aatttggtcc 1827241 actcggagct tataaatcga ttcaattctt tccccttcaa cgagcaaagc ctcaagcttc 1827301 tttgcgtccg ttgatctgct aacagaaaaa atacccaatg aagaacccct ctttctgcat 1827361 ttatctattt gttttatcat tcactacata aaaataagtc ctttatccct atataagaat 1827421 acgacataga agacatttaa accattacga acagattaca tttttcaaat ttttgatttg 1827481 ttttttggct tttaagctgt tgtcatcaag taatacgcac atatagagaa aaaagtttca 1827541 atattcagca atgtttttat aaaaaagtgg tttttaatga tttttttaat tttgttttat 1827601 atttcctgtt ttaaccacaa aaaaaccgca gctgagctgc ggttttatgt atcgactgct 1827661 tttaacaaaa tctgtttgat gcttcaagga agcattacat ctcttcgaag tattctttat 1827721 aatagccgcc gactttattc gtattgtcga ccacaaagag aaactcctct gtttcatttt 1827781 ttacttcata ttcttttccc ggcgttaaaa cgcggtttac gatatatttt tttgcgtttg 1827841 tctgcacaca ctttactttt ttaatggttt ctttttcaag ccaattttta tgaatcatga 1827901 tgaaatctcc ttttcttatc tataagctta ttgtagcttt tttcttttgt aaattgcaat 1827961 atcggttatt cattgatttt gccttgattt ctattataga atgtttgtat acgcttacgt 1828021 ttgaagcaac tatcacagct tatttctgct attcaatcca ggaatcaatg tgctatcacc 1828081 aagaatctca gaacagacca taaaaaatga ctggaggttt gttacggatg agttctttaa 1828141 cgatgcaagt gacgaaaagg ctggagacat ttttacaggg aacaaagaag ctttatattg 1828201 acggaaagtt tgttccgagt gcctcagggg caacctttga cactccaaac ccggcgaccg 1828261 gcgaaacctt gatgacgctg tatgaagccc aggctgcgga tgtggacaaa gctgttaaag 1828321 ctgcccggaa agcctttgac caaggtgaat ggagaacaat gtctccagct tcgagaagca 1828381 gactgatgta taagctggca gacttaatgg aagagcataa aactgagctt gctcagcttg 1828441 aaacacttga taatgggaaa ccgatcaatg aaacgactaa tggagatatt ccgctggcta 1828501 ttgagcatat gcgctattac gccggctggt gtacaaaaat aacaggacag acgattccgg 1828561 tttccggcgc ttattttaat tatacgcgtc atgagcctgt cggtgtcgtc ggccagatca 1828621 ttccatggaa tttcccgctc ctgatggcga tgtggaaaat gggcgcggca cttgcaacag 1828681 gctgtacaat cgtcctcaaa ccggctgaac aaacaccgct ttcagctctt tatttggcag 1828741 aattaattga ccaagccggt ttccctgccg gtgtaatcaa catcatccca ggattcggtg 1828801 aagatgcggg agaagcgctg acgaaccacg aagcggttga taaaattgcc tttaccggtt 1828861 ccactgaaat cggaaagaaa atcatgtcca ccgcagcgaa aagcattaag cgtgtgacat 1828921 tggagctggg cggaaaatcg cctaatattc ttctgccgga tgcgaattta aaaaaagcca 1828981 tcccgggcgc tttaaacggt gtgatgttta accagggcca agtctgctgt gcgggctcac 1829041 gtgtcttcat tcataaagac caatatgatg aagttgttga tgaaatggca tcctatgctg 1829101 agtcactccg ccaaggagcg ggacttcata aagatactca aatcgggcct ctcgtaagca 1829161 aggaacagca tgagcgcgtt ctttcctata ttcaaaaagg aaaagatgaa ggagcaaaag 1829221 cagtgaccgg cggaagctgt ccttttgaag caggatattt tgtcgcaccg actgtgtttg 1829281 cgaatgttga agacgaaatg accatcgcaa aagaagaaat tttcggaccc gtgctgactg 1829341 caattccgta cgaaacagtc gatgaagtta ttgaacgggc aaaccattca gaatatgggc 1829401 ttgcagccgg actatggaca gagaacgtca agcaggctca ctatatcgcg gaccgacttc 1829461 aagccggaac cgtttgggtc aactgctata atgtgtttga cgcggcgtct ccatttggcg 1829521 gttataaaca gtcaggactc ggacgagaaa tgggatcata tgccttggat aattacacag 1829581 aagtcaaaag tgtatgggta aaccttgaag actaacatgt atgtttaaaa aactgctgcc 1829641 tgccagcagt ttttttcttt ctgtaatggc agtaaaagac gctgaatata tatgcttctg 1829701 aaggagttga gcgtgatggg cacacttcag gagaaagtga ggcgttttca aaagaaaacc 1829761 attaccgagt taagagacag gcaaaatgct gatggttcat ggacattttg ctttgaagga 1829821 ccaatcatga caaattcctt ttttattttg ctccttacct cactagatga aggcgaaaat 1829881 gaaaaagaac tgatatcatc ccttgcagcc ggcattcatg caaaacagca gccagacggc 1829941 acatttatca actatcccga tgaaacgcgc ggaaatctaa cggctaccgt ccaaggatat 1830001 gtcgggatgc tggcttcagg atgttttcac agaactgagc cgcacatgaa gaaagctgaa 1830061 caatttatca tctcacatgg cggtttgaga catgttcatt ttatgacaaa atggatgctt 1830121 gccgcgaacg ggctttatcc ttggcctgct ttgtatttac cattatcact catggcgctc 1830181 cccccaacat tgccgattca tttctatcag ttcagctcat atgcccgtat tcattttgct 1830241 cctatggctg taacactcaa tcagcgattt gtccttatta accgcaatat ttcatctctt 1830301 caccatctcg atccgcacat gacaaaaaat cctttcactt ggcttcggtc tgatgctttc 1830361 gaagaaagag atctcacgtc tattttgtta cattggaaac gcgtttttca tgcaccattt 1830421 gcttttcagc agctgggcct acagacagct aaaacgtata tgctggaccg gattgaaaaa 1830481 gatggaacat tatacagcta tgcgagcgca accatatata tggtttacag ccttctgtca 1830541 cttggtgtgt cacgctattc tcctattatc aggagggcga ttaccggcat taaatcactg 1830601 gtgactaaat gcaacgggat tccttatctg gaaaactcta cttcaactgt ttgggataca 1830661 gctttaataa gctatgccct tcaaaaaaat ggtgtgaccg aaacggatgg ctctgttaca 1830721 aaagcagccg actttttgct agaacgccag cataccaaaa tagcagattg gtctgtcaaa 1830781 aatccaaatt cagttcctgg cggctggggg ttttcaaaca ttaatacaaa taaccctgac 1830841 tgtgacgaca ctacagccgt tttaaaggcg attccccgca atcattctcc tgcagcatgg 1830901 gagcgggggg tatcttggct tttatcgatg caaaacaatg acggcggatt ttctgctttc 1830961 gaaaaaaatg tgaaccatcc actgatccgc cttctgccgc ttgaatccgc cgaggacgct 1831021 gcagttgacc cttcaaccgc cgacctcacc ggacgtgtac tgcacttttt aggcgagaaa 1831081 gttggcttca cagaaaaaca tcaacatatt caacgcgcag tgaagtggct tttcgaacat 1831141 caggaacaaa atgggtcttg gtacggcaga tggggtgttt gctacattta cggcacttgg 1831201 gctgctctta ctggtatgca tgcatgcggg gttgaccgaa agcatcccgg tatacaaaag 1831261 gctctgcgtt ggctcaaatc catacaaaat gatgacggaa gctggggaga atcctgcaaa 1831321 agcgccgaaa tcaaaacata tgtaccgctt catagaggaa ccattgtaca aacggcctgg 1831381 gctttagacg ctttgctcac atatgaaaat tccgaacatc cgtctgttgt gaaaggcatg 1831441 caatacctta ccgacagcag ttcgcatagc gccgatagcc tcgcgtatcc agcagggatc 1831501 ggattgccga agcaatttta tattcgctat cacagttatc catatgtatt ctctttgctg 1831561 gctgtcggga agtatttaga ttctattgaa aaggagacag caaatgaaac gtgaatctta 1831621 tcaagcggag atgttcaatt ggtgtgaagc cctgaaagat cagattcaaa agcgaggtca 1831681 gcttgaccag tttgaagatc aaatcgacaa gatgattgag gctctggaag atgaccaaac 1831741 aacagaagaa gattggtata aacaggccgc tgccctttat cgggatatta cagaatcaga 1831801 tgatacaagt gaaagacgcg cttatgtccc tatagggaaa cacgtgctgc caaagcttcc 1831861 ttacaaatac tccgccttag aaccttatat atcacgcgat attatgatcc ttcatcatac 1831921 aaaacatcat caaagctatg tcgatggcct gaacaaagca gaatcagagc ttaaaaaagc 1831981 gagagcgaca aagaattatg acttaatcac tcattgggaa agagagcttg cgttccatgg 1832041 agcaggccat tatttgcata gtattttttg gttttctatg catccaaacg gaaaacggcg 1832101 tcctacaggg gcattgttcc aaatgataga cctttcattt ggaagctatt ccgcttttaa 1832161 agaacatttt acccaggcct ctaaaaaagt ggaaggcgtc ggctgggcca ttctggtctg 1832221 ggcacctcga tcaggacggc tggagatttt aacggcagaa aaacaccagc tctttagcca 1832281 atgggatgtg atcccccttt taccgcttga cgtatgggag catgcctact atttgcaata 1832341 caaaaatgac cgggccagct atgtcgatca ctggtggaat gtcgtggatt ggcgcgaggc 1832401 tgaaaaacgt tttgagcagg caaaagaagt cgtttggaag ctctattaaa aaaagccccc 1832461 tttcctcggg ggcttcgtgt gttaaaaaat acctatcaca tgcaaaaaca cgatgatgat 1832521 ggcaacagga gatagatatc gaatgagcag cagccaaacc gcaaaccact ttcgtttgag 1832581 attggaaccg cttttcagct cgtcaaacaa atcctgtttc ggtattttta gcggaacaaa 1832641 aatcgaaatc agtaacgcac ctaacggcat taaaatattg ctcacaagat agtcagccgc 1832701 atcaaaaata gacagatgaa atatagtgac gtcacttaag acaccgtatg ataatgcaga 1832761 cggcacaccg acaataaaaa tagcaatacc gcctaaccaa gcgaatcgtt ttctcttatt 1832821 gatatcgcct ttcgacagta ctgcgaccaa aatttccagc attgaaaaag cagatgtcaa 1832881 tgcagcaaat aaaaatagaa gtaaaaatgc taataaaaag ataattccga acggcatttg 1832941 attaaacaca gtcggcagaa cgttaaataa cagaaccggg ccttggtctg gcttgaggcc 1833001 gaatgaaaat acagctggaa aaatcgcaat tccggccatt acagcaacaa gcatgttcat 1833061 aacagttaca gatacagcgg actgtaccag attttcctgt ttctctaaat aagcgctata 1833121 cgttaccatg acagatacac cgacacttaa taagaaaaag gattgtccca ttgcatataa 1833181 aatggtattg gcatcaattg cagttaaatc aggcatgagg aaaaatttga ttccttccat 1833241 cgcgccatca agtgtaaccg aacgcaccat taaaatgatg aataatagaa aaagcgccgg 1833301 cattaatact tggcttgctt tttcaattcc gctgcttacc ccttttgcaa caactaaaat 1833361 tgttaccacc ataaagagca gctggcctcc tacagccaaa taaggatttg aaatggtact 1833421 tgcaaatatc gtatcaaaac cagatgtttg cgataaaccg ccagtgaagc cttttataat 1833481 ataaattaaa atccatccgc ctacgacact gtagaaagat agaagaataa agcacgtcac 1833541 catgcctaaa taaccgatcc aatgccactt cgttcctgga gcaagtgttt tataggactg 1833601 aacggcatct ttctgtgttc ttctgcctat gatgaattca cctaacaata aaggcagtcc 1833661 gattaaaacc gtaaataaaa taaaaataag taaaaatgcg cctcctccgc tggttccggc 1833721 aacatatggg aatttccata tcgcaccaag cccgatagct gatcctgccg cggctaaaat 1833781 aaagccgagc ttcgaagacc attgatttgc ttccttcacc gtatcactcc tatttgatct 1833841 aaccattata aaggttcatt gtaagaatat cttcctatat agtcaagaac attttaatta 1833901 gtttacatca tatatctata gacatctgcc aaaaactaat attgaattat tcagaaaatt 1833961 atttataata agagaatgtt atgaaatttg taagaatttc tgctgaagtt cttgataagt 1834021 gtgttaggag tgtttttatg gacatcatta gaaaaataag ccattttgca ggacaaacct 1834081 ttggcatatg ggtcattgtt tttgcagtgc tgggattttc tttcccatct ttatttacgt 1834141 ggatcagttc ttatattacg atttttctcg gcattatcat gtttgggatg ggccttacac 1834201 tgcaagccga tgatttcaaa gagctggtca gaaagccttg gcaagttatt attggagtaa 1834261 tagctcagta tacgatcatg ccgctcgttg ctttcggcct cgcatttggg cttcatcttc 1834321 cagctgaaat cgcagttggt gttattcttg tcggctgctg tcccggggga actgcatcta 1834381 atgttatgac attcttagca aaaggaaata ctgccctttc tgttgcggtt acgacaattt 1834441 ctaccttatt ggcacctgtt gtaacaccgt tgttgattat gctgtttgcc aaagaatggc 1834501 ttcctgtctc gccggggtct ttgtttatct caatcttaca ggcggtttta tttccgatca 1834561 ttgcaggtct gattgtcaaa atgtttttca gaaaacaagt ggcaaaagcc gtacatgccc 1834621 ttccgcttgt ttctgtcatt ggcatcgttg cgattgtctc agctgtcgtc agcggcaatc 1834681 gggaaaatct gcttcaatcg gggttgctca ttttttcagt tgttatcctg cataacggta 1834741 tcggttattt actggggttt ctttgtgcaa agcttttaaa aatggattac ccgtctcaaa 1834801 aagcgattgc aatcgaagtc ggcatgcaaa actccgggct tggggctgca cttgccacgg 1834861 ctcatttctc accgctatct gccgtaccaa gcgcaatatt cagtgtgtgg cataaccttt 1834921 caggttctat gcttgcaaca tattggtcaa aaaaagtgaa aaagaagcaa gctggatcca 1834981 aaagcagcaa tctatcactt taaatatgca tcaaaaaggg tacatcactt tatcgtgatg 1835041 tacccttttt tattatcctt ctaataaaag ctgttcagga tcttccagta aatttttgat 1835101 tgtcacgagg aaaccaaccg cttctttacc gtctacaatt cggtgatcat aagataaagc 1835161 gatatacatc atcggacggt tttcgaaacg ctcttcatca atggctacag ggcgcagctg 1835221 aatcttatgc atgcccagta taccgacttg cgggctgttt aaaattggag ttgacatcaa 1835281 tgaaccgaaa gtccctccgt ttgtaatcgt gaaggagcct ccctgaagct cgctaagggt 1835341 taatttattg tttcttgctt ttttcgcaag ctcgccgatc tctttttcga ttcctgcaaa 1835401 tgtcaggcga tccgcatccc gtacaaccgg aacgacaaga ccttcatcag cagcaacagc 1835461 gattccgata tcgtagaatt ttttaacgat caactcatcg ccttgaattt ctgcattcaa 1835521 cagcggatat tttttcaatg cagccacgac cgctttcgtg aagaaagaca taaagccgag 1835581 cttcacttca ttttgctcaa aaaattgatc tttgcggcgt tttctgagat tcatgacagc 1835641 cgtcatgtcc acttcattaa atgtagtcag catcgctgat gtttgctgta cctctacaag 1835701 gcgttttgca atcgtttgtc tgcggcgtga cattttttgc acttcaacag gtttgtcaaa 1835761 gctttgctgt gctttttgag cctgaggctg ctgcttttgc tgaggagccg gttttgatgc 1835821 cggtttttcg tacgcttcga catcctgctt gcgcactctt ccaagcggat ctccagttgg 1835881 aacttgagac aggtcaattc ctttttctct cgcaagctta cgggccgacg gagaagcgat 1835941 cgttcttgat tttgcttcag attgtgcttc ctcgctcacc tcttgtgcag ctggttcagc 1836001 ctgtttctct tcttttacgc tttccttgct ttctgttttc tctgtaggag caggggcaga 1836061 actttcaccc gcgccttctg aaatcgtacc gataatttct ccgacctgga cggtatcacc 1836121 cgaatctttc aatacctctt gaagtacacc cgattcttct gctgtcaatt caacattcac 1836181 tttatccgtt tctagttcaa gcagatattc accctgttct acatagtcac caggctgctt 1836241 taaccattgg gctattgttc cttctgagat tgattctgct aattcaggta ccttaatttc 1836301 cgccattttt tcatttcccc cttagttttt gcgagtcaag ctatcagata caatacgttc 1836361 ctgttctttt ttatgaactg tcggatctcc ctctgcaggg ctggatcgtc ttcttcgtcc 1836421 aatatattga acgcttactc cctctggtgc aatctctgtc aaatacgggc tgatataacc 1836481 ccaagccccc atgttctgcg gctcttcctg cacccaaacg atttctttca ggttcggaag 1836541 ttttgcaaat aattctttga ctccttttgc cgggaatgga tacagctgtt cgattctcgc 1836601 aatgtgaagc cactctttac cgtcttctaa cttattaaaa tgatcgctaa tgtctataga 1836661 cactttaccg ctggataata caagtctggt tactttttca tagtcatgag aaagtcccga 1836721 ctgttcataa acaggctgga agcggctttc gctgagctcc tgcacttccg acaccgtatt 1836781 tgggttgcga agaaggctct tcggcgtcat aatgacgagc ggtctgattt cttcacgaag 1836841 cagcatttta gcctgtcttc ttaaaatatg gaaatactgt gccgcgcttg tcaggttggc 1836901 aaccgtccag ttgttttccg ctgcaagctg caggaatcgc tcaattcttc cgcttgagtg 1836961 ctcaggcccc tgtccctcgt aaccgtgcgg gagcagcatg actaatccgg atttttggcc 1837021 ccatttcgcg cgtccggcag aaataaattg gtcaaaatac acttgagcag cgttggcaaa 1837081 atctccgtac tgtgcttccc acaaaacaag cgtttccggt gaatgcacgt tatagccgta 1837141 ttcaaaaccg agaaccgatc cttcagacag cgggctgtta tgaacagcaa atgatgtgct 1837201 gcagtcagat aagtgatgaa gcggcacaaa ttctttgccc gtctcactgt catgaagcac 1837261 aaggtttctt tgggcgaacg ttccgcgctc ggaatcctgt cctgttaaac gaatcggtgt 1837321 tccgtctttc aaaattgaag caaacgcgag tgattctgcc aaagaccatt ccacttttct 1837381 gtcatcatcg aacgccttgg cgcgtctttc taaaatgcgc tttagcttgc cgaaaacatt 1837441 aaatgactcc ggccagttga tcaattcgcc attcagcttg cggagcacat caaaatcaat 1837501 cgaagtgtcc acatctggga aaccgtttga tacaggctct ggaagttcaa tttcacaagc 1837561 agtgtgttcc tttttagacg gaactttctg atatgcatcc tcaatgcgct tcgttaccga 1837621 tttttcgatg ttttgaacga cttcctcggt aaccacgcct tcttttacca gcttttcagc 1837681 gaaaatttgt ttgacggtcg gatgctttct gacagcatca tacagcattg gctgagtggt 1837741 tgacggttca tccatttcgt tgtgtccata gcgtctgtac ccgatcaaat caatcagaaa 1837801 atccttgttg aatgtttttc ggtattcgac cgcaaactta acagctgaaa gacaagcttc 1837861 aggatcgtcc gcattcacgt gaacaatcgg aatttcataa cccttggcca ggtcgctggc 1837921 atattttgtc gatctggatt cagcgctttc tgttgtgaat ccgatcatgt tattggcgat 1837981 aatatgaatc gcaccgccta cttgataccc ttttaaagag cttaaattca atgtttcagc 1838041 tacaattcct tccccaggga atgcagcgtc tccatggatt aaaatggcca gcgattttgt 1838101 ttcatcttgt accgggtatc cgctttgtgt tcgcgtttcc tgtgccgctc ttgtgctgcc 1838161 ttcaacaatc ggattgataa attccaagtg gctcgggttg ttcgctaacg taatgcgcgc 1838221 tgattttgtt tcagcgtctt gaagctcccg attcgccccc aaatggtatt tgacatcccc 1838281 cgtccatccg tagctgattc caatggatcc ctcagacggt acaagatctt tgttcggcgc 1838341 atgctggaat tcagagaaga tgatttcata cggtttgccg agcacatgtg ccaagacatt 1838401 caggcgtccc ctgtgcgcca tcccgatgtt gacacttgtc gtgcctgatt tgacagattg 1838461 tgcaataatg tcatcaagca ctggaacaag agcgtccaga ccctcaatgg aaaagcgctt 1838521 ctgcccgacg aatgtgcggt gcaaaaactg ctcaaagccc tctacttctg tcaatctttc 1838581 cagcacagct gacagctttt cagctgagtt cttctggaac agctcgccag attcaatctt 1838641 tcttgtcagc cactcgcgct ctttgaagtc atgcacatgg tcaaattcaa aagagatggt 1838701 tcttttatac gtatttcgta aatactgaat ggcttctaaa ccgttcgaaa tgtttttagg 1838761 agcgtctttg cagatgacag acgcaggtat tgcttttatt tcctcttctg ttagcccgta 1838821 atcggataat ggaaaaagtt cgctcttttt ctcatccttt ctgagcggat tgacggaagc 1838881 gttcaaatgg ccataggttc ggatatcttc tgcaagtctg actgcggatg cgatcttttg 1838941 aatcagatcg gctgtaacac gtcccttttc ttttgttccc gaggcctctt ttatatcgct 1839001 tggcggagca ccgagctcgt cgaacatttc cttcaaatcc gggtcaatgc tgttcggatc 1839061 ctgggtatac tgatcgtaaa gctccagcgc atagccgagg ttcggaccgt aaaaatcttc 1839121 ccaattcatt cgttgtttca tactattttg aaacatttga atattacccc caacttaaat 1839181 aatcaagtga ttgattcact atcttgaaat aactttcgaa cgctgtgtcc aaaattatgt 1839241 aataaaaacg cttccaacga tattttacca ctgtttgcaa tttgattcta ccttgattgt 1839301 tcacaaaata gtaaaaaacc tttataaaaa acaaaaaatt taatcattcg aaaaaacaaa 1839361 cgccaaaaag cataggatta agggctatcc tatgctttta tgaagcagtt ttttcagcag 1839421 cggatacaaa acatccggta gctgatcaac atccgggaca aatatactga attttccgta 1839481 catatcctgg atcgtcttca tttgcgattc ttctatttct gagttggaga gaaaaacatt 1839541 tatcacttct attcctcttt ttcgggcttc gataaccgcc tcacttgtat caacgatccc 1839601 attttgttcg tagccaaatg cggccggctc tccatctgag aaaacaatta agaacttttg 1839661 cgcctcgctg cgatgcagca tttttttcgt catctgccta attgcgtacc cgtcacggtt 1839721 atcttcttct ggctcaagct gcataatggc cggtccagaa tcttgtctta atgatgattg 1839781 gaagggaata accgtattga aatagtttgg ctggcttttt tcggttgcat catttgtgtc 1839841 ctcccaaaaa ccgacaatct gatgcggaac cgctaccgat ttcaacgctt cgtgaaacag 1839901 cacgattcct cgttttgttt cgtccatttt gtcgaacatg ctggcggaac aatcgaccag 1839961 caatgtaaaa actgcgtcga tttctgaaga tggttcttgc tttttgtaga acaggcgcgg 1840021 atttcgctca gtgaagtaac gaagaagctt attgttcagt ctcccggcat gaaggtctgt 1840081 tctcggcaat gtttttttat gctccagcgt tttttgaatc atttgtttca aacgcttttg 1840141 atacgattca atcgtttttg cctgctgttt ataagaaagc tcttcttcac tggttgccgg 1840201 ctgcggttct ttataaattg gaaatgcata tttattttct ttgccgtcag ccatacccgc 1840261 tccgttcggc tggtcttttt gggactccag cgcttccagc ttggaatagt ctttccgttt 1840321 cgtttgtctg gctgatcctt gaacagagcc aagggcctga tctccatcgt cgccttccct 1840381 tgaagcatct tttcctaaat ctgattttgc gccgtgttca atatcaaatt gaaggaagct 1840441 tttagacggt gcttctgttt cccggtgcca tgtcggcatt tcttcttcat ggatatcctc 1840501 atcaccgtct gattgttttg gaagcgtgat gtcatcactc agcttcggcg cttttttctc 1840561 ttcttcaaat aacggctgtt ctgcagcttt tgcgtaatca agctcaggca aaaagaagta 1840621 ggtgttcaac atgtctttat cgagtacctc ttcaagtccg tccatgaggt cctcaacaat 1840681 tttcagaacc tgccgtgtcg aatctgcttc atacacacgc aagagctgct gctcaataaa 1840741 cgggcgcatc agatcgatat cttcacgcat ggatggaagg gtctcgagcg gcgattccgc 1840801 tgtgagcttg aaatagatcg cgcaaaagag cgcatcggta aaaatgcttc gttccaaatt 1840861 taaggtcagc tgggttgaga aatgttttct gtacatgtct tttcgcttcg caaatacatg 1840921 tttcgtaccc gggcgctcac gtttgatgca ttcttcgatc ctaatgtctt caagcagcat 1840981 aaagagctgc ttggcaaaac ttttaaacgt aagatggcga tggatatcat tcaaaaagtt 1841041 cgcaaactca tgcagcgagc tatatcttgt tccgactgaa cgcaggtaga cgtcgctttt 1841101 cagacccgct tccatgtcct cagctgccct gtctttccaa aagtggctca tatagatttt 1841161 cttttcaaat ggattgtaat aggactgaac gccatactcc acttctaccg cttcactctt 1841221 ggtgagtgtt ttggccaaat cagtcagcat cataaataaa aatgaatcaa tcgtgctgtc 1841281 gttaaatttg ataaatttca tcgcagcccc ctcattcaaa cagagtttct gcaatatttc 1841341 ggacagccgc tttttcccga tcatcatcaa gcttttctac aattccccgc tcaatggcac 1841401 gacgcggcgg aatataagca gctaaatcac atgtatcgat taaagctctg atggatgccg 1841461 cttcttcaga cacctgtccg ttattggcct gaacgatcaa gtcagaggaa agcgtgataa 1841521 atctgtcaat caatttctcg tctttcaagg ctgactgaga catgagcact tgtttcagca 1841581 gctcgccttt aatataaggc acatcaatga tgacaaaacg gtttttcaac gcttcattca 1841641 gaggaacagt tccgacatag ccttcattga tggctgcaat gactccgaaa ccgcttttag 1841701 cccgtatgac ctcgcctgta aacggatttg tcatcatttt tctgtaatct aatacaccgt 1841761 ttagaatagg cagtgtttcc ggcttcgcca tattgatttc atctatataa agaaaatggc 1841821 cttccttcat tgcctttgta acaggtcctg aaacaaactc gattgttgcc tggccagatt 1841881 gattttcaat cgttttataa ccgaccaatg cctcagcgtc caagtcgact gaacagttga 1841941 cgctgtgcat cggtttatga aaatagctgg acaatgtttc tgccagcttt gtttttcctg 1842001 aacctgtagg ccctttcagc aggacatttt tccccatggc taatgcaata atggcgtcaa 1842061 ataaaatggc ttcatcctcc gcctcatagc ctgatgttcc tataagcgat tgaaactctg 1842121 gggaaatagg ctgctcttta tatgataaaa gcttttgttg tatatcttcc ggcaatgtta 1842181 agtgctgtag ttgagttgtc atagacagat tccctttcct attcatattc cattaacgag 1842241 tatactaaaa aagcccctgt atgctcaata caaaagggcc tggatgatat tactgcttct 1842301 cgttatttcc caaaagggct ccgcagacaa tacgcgcacc ggaattgccg cttgggtttg 1842361 tcagataatc gtccgcttgt tcatgaataa taaatgcact tccgtcctcg tcgagaatat 1842421 ttagtttact tccttttttc agtgaagtgt caggcgcatt cattatgaca tctacctttc 1842481 catcagcacc gacttcaagg ttcggcagat ctccggcatg atgccccatc ggattattaa 1842541 agccgtgttc tttgttcagt ggattaaagg gaccgcccgc tgattcaaaa tccggcctga 1842601 cacaagaacc tttctcataa atatgaaaac cgagagaagc acctggacgc aggctgtttg 1842661 cggaaatatg aatatcgagg ccttcatcat ctgattcttt gatctctata aaaccgactg 1842721 ctttcccttc acgattgacc agctggacat gatgaccaaa cgctgacgtt tcaaccactt 1842781 ttttttccgg cacccggtta ggagggtctg gaggtttttt ttgtccgcat ccggcaactc 1842841 ccagtgccgt cagcatcatc aacagcaaga gacggtgcat actgtctccc ccttgttttt 1842901 tctaacagtg tggtcaatca ttgtctggta taaacaaaaa agcctataaa aggctttttg 1842961 tcatactcat ttttaaaaat aacttcttgc gcccaagtac cgctgtttcc aatacgaatt 1843021 gctgagattg gaaatgtcga cgcccgatga gcttgcatga ataaaatcac cgccgcctag 1843081 ataaatcccc atgtgagacg ggccggattt atatgtggta aagaagacaa agtctcctac 1843141 tgacggctgg ctgactttct gcatgacatt ccaataccct gccgtactca atcttgatat 1843201 agatgataca ttattaatga ggtaataaat gaagccgctg caatcaaaac cggcaggcgt 1843261 gtttccgccc catcggtaag gcactccgac atattttttc gcttccgtta tcattctgtc 1843321 aatcttcgaa cctatttgaa tgtttgaccc tgagttatct tttggctttg ttggctttgt 1843381 cggatttgaa ggattagatt ttgatgctcc cgaaatagtc agaacctgcc cgatttgcaa 1843441 cacatccgat gataaattgt ttttatcacg gatgctttgg acagtgactc cgagccgatt 1843501 tgcaattttc cacagcgaat cgcctgcttt taccttgtac gtcgttgttt ttgagggatt 1843561 ggagtttgac ggctttttgg aaccgctgtt tccgttctta ggtgaactgc ttccttttat 1843621 tttgagcacc tgtttaggat aaagtgtatc tgatgttaag ccatttaagg tttttaattc 1843681 ggctacagtc atatttaagc tgtttgcgat tttccacagt gagtcaccaa gcttgaccgt 1843741 atatgtactt tttgaagaac ctgaagaatt ggaaccgctg tttttctttg atccatttga 1843801 tccgcttgaa ctgcttgtcc ctttgatctt aagcttttgc cccggacgaa tcaggtcact 1843861 gctcaggctg tttaagcttt taagctcaga aacactcatt ttatgatttt tagcaatcat 1843921 ccatagggaa tcaccatatg caactgtgta tgttgatgtt ttgcttgaat tagatgggga 1843981 tgtcgtgctt tttttgctgc tttcaggaac cttaagactt tgtccgacat aaagcaccgt 1844041 tgatttcaat ttgttttcgg atttcagagc tgatattgtc gtatcatact ggcgggaaag 1844101 tttccaaaga gagtcaccgc tttttacttt tatcgttttt gcttccgcgg gtgctgcggc 1844161 catcgacgac ccaacaactg cagaaacagc caagccggct acaatcttct ttttcattca 1844221 ttcaacctcc taaactgttt ttttgcaaaa acagctagta ttttgtttcc aaaaatggca 1844281 cacaactgtt ttatcgtcaa tttttcagca agttaaaccc ttttcaaaca tttggcgcag 1844341 cattttcagc atcgttcgac ctttaaacct tcaaataaac atctaacatt ttacataagc 1844401 acgatatgtt tttcgaaagt ctaaggaact atttaagcga gggtaaaaat gatggttttc 1844461 tattgatgaa cgaagcagtt tctcctcctt tcttgtctat ttttctaatc aattctctat 1844521 cggcgtgtca aatcccttcc tctgcattct tatgaaatgg caaaaagcct gttctttcga 1844581 taagaacagg cttttacact atgcatttgc tgattgagtt ttttgtttta cagcttcaag 1844641 aatgctgtcg gctgcttttt tagagccgcc tgccgctttc agtgattgtc caatttcttt 1844701 tgccttttca gcatacgaac gattattcat tacttcttgt atcgtctctt tcagtaggct 1844761 ttcagacaat tcttcctttt taattacttt tcctgcgccg actttttcta cctgatctgc 1844821 gacaacaaat tggtcgcctc ccatcggaat gacaacgagc ggggtttcaa aatacaaacc 1844881 ttcacttgtg ctgttcattc cgccgtgggt cacaaataag ctggctcttt tcaagatctc 1844941 aagctgaggg acatacgggc gtacaatgaa attctccgga atgtcgttta actcacttgt 1845001 tttaatatgc ttgccgatgg aaagcacaac tttaccgtca aagtccttac acacttcaag 1845061 gcattgatta aaaaactgct tttgattatt aaaaatggtt cccattgaaa taaacagcac 1845121 gttttcattg tcaatctgat caaatgggaa atcattgttt ccggctcttt ctgtaatgga 1845181 aggaccgaca aatacatatc gctcgccaaa ttgctcagcc agtggctgaa atccccttga 1845241 tgtaaagacg attgtcaagt caccatcagc taaaaaaaca tcaaatggct tcttgatctc 1845301 tgcttgaaaa tcagcattta acgtttctgc aagctgctgg tatgattcat aatgaggcga 1845361 atcttcaagt gatcctttca tgtacgctcc catcatttcc ttcgcaaatt cctcattcat 1845421 cgcaaaggtt gtacacaatg aaaatcttgg cagcttcagc atgttggcaa tgactttacc 1845481 cgcgagaaga tggtgatcat atatgacata atcatacgat tcatgtttga cttcctcata 1845541 aatatgagtc gcgatatcct tacaggcttt caaaaaagcg cagagcattt ctgtgaaatc 1845601 tctttcttca tcgccggttg cgtttttccc gaagtaatct cctctgaaat catgatactc 1845661 acgaaactct atatcaagag ctgtgatttt ttctttatat tccttcactg cgtagtacgt 1845721 aatgttttct ccccgggatt tcagctcctt catcacaccg atagagggat taatatgccc 1845781 ttcaccgggg aaaccgatca ttaatacatt agccatgcgg cagcaccctt cctttgagaa 1845841 tttatgtaat attttatacg gtactataaa tgcataaaca ggtaaagtat ttcacttaat 1845901 taatattcat catatataac ttttctacca gtttatattc cctgtcttca agacaaaaag 1845961 cattcagctt gaagcgaatg ctttaataaa gatgcgaatt cagtcatttt gtctcatgat 1846021 aggattctta atcaggccct ttttattatt tttacgttct tggtgaaatt aacggatata 1846081 atacaccgtc tttggcaaac gacatcttcc ctgtttcctc tgaaaccacg agcaccagtg 1846141 catccgtata gcccgacata ccaagagccg cccggtgccg ggttcccaaa tggatatcca 1846201 cttccttcgt cgtcagcggg agcacattgg ctgctgacac gagtttgttt tccctcacta 1846261 ataaagcgcc gtcatgaaga gggtttccgg gaaaaaagat gctttcaatt aatgaagagc 1846321 tgatctcggc gtgtagggag gtgccttttt gaataaaacg ttcaaccggg tctgctcttt 1846381 caatcacaat taaagctcca tgcttatgtt ccgataaggc tttaatcgcc ttggccagct 1846441 caataaatgc cggcgtaaat tcctcaatgt atgattgcaa ataaaaggag gatgcaatcc 1846501 cctgcatgtc ctgaaaaacg tgccccaaat catctaattc acaaaggaga cactggtctt 1846561 tttcgtgaag cgttttcaag attagagatg catcacctaa tatttgctct aagtacacct 1846621 gtattttccc cttgaacgca ttttctgata tctgctcata gcgcatagcc ttcatctcct 1846681 gtttaaattt ccaacttttc acgaatgctt atcttattga tgcacattct attggtaaag 1846741 gagggatgta aagaatggaa atcgaaagaa tcattcagta tatttgcacc tttttaggcg 1846801 tgatttcgct ttcttttatt tatgcccaaa tgtttagaaa aacgaaaccg acaaaaaaag 1846861 aataggcccg gcgttcattg ctttttatac ataaaatgtt ataatttctc tcgttatgaa 1846921 aaagaaacgg agatcaatgt atgaaagaaa ctcaaaacgc ccgggaaaaa atcaaacagc 1846981 tcttgcacat tttaataccg atattcatta cccaagcggg gctttctctg atcacttttc 1847041 tagatactgt gatgtcaggg aaagtcagcc ccgctgattt agctggtgtc gccattggct 1847101 caagcctttg gacccctgtt tacacaggac ttgcaggtat attaatggcg gtcaccccga 1847161 ttgtcgctca gttattaggt gcagagaaaa aacagaagat tccctttact gttttacaag 1847221 ctgtatacgt ggccgcgctt cttagcatcg ccgttttagt gattggatat gctgcagttg 1847281 accttattct tggccgattg aaccttgata ttcacgtgca tcagattgct aaacactttt 1847341 taggcttttt atcactggga attttccctt tatttgttta caccgtgttg agatcattca 1847401 tcgactcatt aggaaaaacg agagtcacca tgatgattac actcagttct cttccaatca 1847461 attttgtatt gaattatgta tttatcttcg ggaagttcgg aatgccggca cttggaggtg 1847521 taggcgcggg actggcatcc gcgttaactt actggtgtat atgcatcatc agttttttca 1847581 ttattcataa aaacgcaccg ttttctgaat acgggatttt tcttaccatg tataagttct 1847641 cttggaaagc atgcaaaaat ttgctcaaaa tcgggctgcc tattgggttc gccgtgtttt 1847701 ttgaaacgag cattttcgca gctgtcacgc ttctcatgag ccattttcat acagtgacca 1847761 tcgcgtccca ccaggcagcc atgaattttg cgtctctttt atatatgctg ccgcttagcg 1847821 tgtccatggc tctaacaatt gttgtcggat ttgaagcggg tgcagcccgt tttaaggatg 1847881 cacgctcata tagcttaatc ggcatcatga tggcgatcgg cttttctttg ttcactgccg 1847941 cctgtatcct tttattcaga gagcaaattg cgggcatgta cacttctgac cccgatgtgc 1848001 tccggctgac acagcacttt ttaatttatg cgctattttt tcagctttcc gatgctgttg 1848061 ccgcaccgat ccagggagca ctcagagggt acaaagatgt gaactatacg cttgcggccg 1848121 cttttgtctc ttactgggtc attggccttc cggtcggtta tatggtcggt acgtttacaa 1848181 gcctcggtgc attcggctat tggattggat taatagcggg actcgccgcc ggagcagttg 1848241 ggctgttttt caggctggca aaactgcaaa aacgttattc gcaaaaacaa cacatttaaa 1848301 agaggtgatc aatcatggca aaaaacaaaa aattattcga gtatctttcc cagcatgcgg 1848361 aaaccatcag ttcaacatgg tatgaaacaa tcgaggagac tgatcccaat tccatttatg 1848421 cctcaacaga ccctgttgtc attcacaatt taaagagcca gaatcttgcc tttaactata 1848481 aaataaaccg tatttttata gatgatgagg acgtatactt gcctatactg aaagaatggg 1848541 cctttgaagt cacacaggat caagagcatt taaaaactcc tatccactat attattcggg 1848601 agtttgtcag agtgagagat ttatatgttt cttatgtgaa agaatttgtc catctcaatc 1848661 agaatactgt gaaaagcgaa gaagccgaag acctgtatca cgcccttata aaagcgtttg 1848721 atcttgtgat tcatattttt atagaagaaa tgtacaaaaa cacaagcctt cagcttcagg 1848781 cccaaaaaga tatgattact gaattgagcg ctccggtcat cgtgctgttt cacagcgtcg 1848841 gactgctgcc tttaatcgga gatattgata cagtccgcgc caagctgatt atggaaaaca 1848901 cactgcatca atgtgcgaaa aaaaaggtga cacaactgta tattgatttg tcaggagtag 1848961 ctgtgattga tacgatggtt gcccatcagc tgttcagtct gattgaggcg cttcgtttaa 1849021 tcggtgtttc ttcaactttg tctggaatcc gtccggaaat cgcgcaaaca gcggttcagc 1849081 taggtttgtc tttcgaaggt atttccttga gatccactct cgcttcagct attgcatcgg 1849141 acttaaaatt aaaaaaggta taaggcttaa ggccttatac ctttttgatt aatcattcca 1849201 ttgatacgtc caatatattt cttcttcaaa ccatgttgcc ataacaggtt cattattttt 1849261 caatttctct tcaagctctc tgagcatgcc ttctgtttgt gtgcggtgag ctcttaacgc 1849321 attcatttta atatcagcta cttctttgat atcaagtacg acatcagctt cgccgagaac 1849381 ctcttctctg ttgcgggtaa tggccatgca gattgtacgc ggacggtctt ctttcttttt 1849441 gcggtataat gcacggataa ccgcttcccc gcatgcatca tggtcagggt gcacaccgtg 1849501 tccgggataa aatgtgacaa ttaaacttgg ttttacatca tctatgatct cttccatgat 1849561 atcagctaaa tactcatcgt cttcaaattc gagcgttttg tcacggagtc caagcatccg 1849621 aaggtcattg atatccattt ctttgcaagc gttgatgagc tcttgttttc ttagcagcgg 1849681 caacgtttcc cgattcgcga aaaatggatc gcccatattt ctgcccattt cacctaaagt 1849741 ggcgcaggca tacgtaacgg gaatgtcttt ttttctgttt aaggcaatga ggcctgccac 1849801 tccatatgat tcatcatcag ggtgaggcag gattactagt acatgttctt tcattattat 1849861 tcaccctttt ctttaaactg tgaacggttt ttcgctgatt tgcagagaaa tagccagttt 1849921 accgcccggc aggtgtcccg ccattaataa acggttttct tcatctaccg tgtattcagt 1849981 caagccttca gcataaatcc agccttcttc tgttttcaag ccaacgcggt aaggcccgtt 1850041 gcctttgatt tttgcctgat gataagtgac ttttgcattg cgaatatacg caacaaccgt 1850101 catgttcttt tcatttaagt gcgctgaata agaacctgtg gtggtttcta aatggatata 1850161 tacagggcgg tccgcatatc gttctaaaga tgcttgcaca tcttctttta tgatcgcttt 1850221 catgattgct cccctctttc ttcttttaaa tactctgcac gttctgtatg taatttgacc 1850281 agctgatatt tcacagccgg ttcgagctgt gaattcacaa tgcgctgaat cgcggcaaaa 1850341 tatttttcca gcatcggttt tcggagtctt ggatgtgttc gtttatccaa gagctcaaga 1850401 tcaatcgcct ctgctaccgc ttctgcgtca tcatgtgcga gagatcggtt attccaaagt 1850461 gaagcatagg ctttcactat ctctttatca ttgtccatcg tcttgctcct ttatgtctta 1850521 catacatgaa atgattatac ataatatatg catcagctga aaagccaaag gcctcaatgg 1850581 ctttttgacg cccgtttcca cttcacttgt gaaaacgtaa acaagagcag cgcagcccat 1850641 atacagctga atgtaaaagc cttcgagctt gaaaatggct catggtaaac aaacagcccg 1850701 atcagcaggg taatggtcgg cgcaatatat tgtaagatac cgacttgata cagtggcagc 1850761 cgtttcgctc cttccgcaaa caataagagc ggcaaagccg taaacacacc ggccaaaaag 1850821 agaagcagcc acgtccctcc gctttctgca cccgctggct gaacatgtcc gctgaacagc 1850881 aaatacccca atgcaatggg cataatcatg aatgtttcca gcgttaaacc gatggcgctc 1850941 ggcaggcttg ttcttttttt gcttaacccg tacagcccaa agctgaatgc gagcagaagc 1851001 gcaacataag gaatggagcc gtattggaac gccgagatga tgacaccggc tgccgcaatc 1851061 gaaacggcca ctaattgcag gcgattcagt ttttccttta aaaataaaat cccaaggagc 1851121 actgatacaa gcggattaat gtaatagcca agactagcct caagcaaaaa gccatggttg 1851181 acagcccata tgtatacaaa ccagttgatc gaaatcagga tagaagcaag aaataaagag 1851241 aggatccctc cgttcttttt cagagagcgc aactcctgcc atcctatttt ccattgccgc 1851301 aagaaaaaaa gtacgataca cataaaaaca aaagaccata taatacgatg agccaaaata 1851361 tcaagagccg gcagctgttc gagaagcttc caatagagcg gaaacaggcc ccacatgata 1851421 aatgaaacgg ctgtgtaaat aacgcctttt tttgtttctg catgttgcat tgatatccct 1851481 gcctttcttt agagcatctt atattatatc acgtgaaaga tctggtgggc atatactatt 1851541 ttgtccgtga agaaaggatg tgaagacaat gtttgagtgg aacaagtact ttcctttcca 1851601 caatcaattt tctaaagaag cattaaaaaa agctgatccg aaagaagttg aaacgtatgt 1851661 caatcgtgtg atggaaagtg tgttcggcag tgattatgcg gctcaatttc ctttccgcga 1851721 tcctctcccc caaaaagaac atcccgccaa acctgatgca aaacctgatg tcaaacctga 1851781 tattgatata ttcgaaacag cagaccatgt gtttgtaaag gtgccaatca gcgaagaatg 1851841 gctggaacaa gtgagaatca aacacacatc tcacgaatta tggttggaaa acctcccaag 1851901 agcagatcat ccgaaaaaag taaaccttcc ttgtttagtc aaacgcaaag gaacaaaagc 1851961 cgtctataag gatggccttc tggaagtcat gtttcaaaag cagcaagact acaatatgtc 1852021 cgaggtagaa atcatccgat aaaaaacggc ctgcaatcga tgcaggccgt tttttattaa 1852081 tagaagccgg gatatccccc gtatggcacg ccggcaccaa aaccgtacgg tccgcctcca 1852141 tatccataag ggccaggagg ataggcatag ggacgagaat agttaaacag cgcactcccg 1852201 agaaaaccgc ctaataaacc gccgactaga ggagcgccaa acaaaaaagg actacgcgcc 1852261 ggatatccgg ctggacctgg gattccgcgt aaatacgaat gatgagggta catgattttt 1852321 tcctccttta tgtctgccta tacgtaaagt attcagcaag gaagaaaaac gattgggcta 1852381 cggactgtct atgattgtta catcacaagc cctgccaata acacacagcc gagccctgta 1852441 accgaaagaa ctgttgtaag cagcgtccag gtttgaaatg tttctttcat gctcaagccg 1852501 aaaaattcct ttaccatcca aaatcctgca tcatttacat gacacgcaat gacactgccg 1852561 gctcctgttg caagcaccat taacgcaggg tttacactgc cagcctccat aagcggagct 1852621 gccattcccg ctgtggtaag cgcagccacg gtagcagagc ctagacacag acgcagaacc 1852681 gcggcgatgg tccatgcaac gaatagcggc gacatgtttg tttgacggaa aaaatcagcg 1852741 acataatcgc cgactccgcc gtcaatcagc acctgtttaa acgctcctcc ccctcctatg 1852801 atgagcagca tcatcgcaat ttgcgaaatt gattctgaaa tagatctgcc gatttcctgc 1852861 atagatattt tacgggcata tcccatcgta tagagtgcaa gcaacagcga aatgagcatt 1852921 gccgttcccg gagtgccgat aaattctata atgtcttttc cttttgaatg ttcactcaat 1852981 aataaagaaa aaattgttgc cattgccata aagataaccg ggaataaaga cgtgacagca 1853041 ctgatcgcaa agcccggtgt ttcatccagc tgaaattctt tccttggtcc taaccccgat 1853101 aggtttccat gcttttgata cgcaccagga aaccgtttca tcgcaaattt attaaataaa 1853161 ggcccggcaa tcacagttgt cggaacagcg atgatgattc caaaaagcag cacctggcca 1853221 atatgggcac catatgcaac tgagatagca gttggagcag gatgcggggg caaaaatccg 1853281 tgagtaacat ttaaggcggc ggccatcggg attcccagat acagaaaagg catttttaat 1853341 tctttagcaa tcgcgtaaac aatcggtatc aacagaacaa gaccgacttc aaaaaatagg 1853401 gcaatcccga tgataaaaga ggcaaccaca accgccgcct gtattcgttt cctcccgaat 1853461 ttgtcaatca gcgtaatggc gatccggtag ccgcccccag catctgagac aagcctccca 1853521 agcatcgcgc caagtccaaa cactaaagct aaatgcccca gctgcccgcc aattccagtc 1853581 tcaattgaaa gaacaatttt attgatatcc attccaagtc cgatggctac taaaaatgaa 1853641 acgacaatca gtgagacaaa ggtatttaat tttactttaa taatgagaaa taacagaatc 1853701 agcactccga cagctacaat taaaatcggc atggtacccc tccaaaagtg ttttatatga 1853761 ttctcgcgac aatgttttgg cgcttttcat gcctagatga acagaaagcg ctttcattaa 1853821 taactaaaaa cgtcttggtt atatgattgt tatcttttga tcaactaata tgttcatact 1853881 aatctcctaa tcaatgactg tcaatcgttt ttatgagctt gtctcgatta cctaccgcct 1853941 aacccaatga tttattagtt atatgttgat taacttttgg ttatatgtta tgttttttaa 1854001 agttgactgc caatcattat atctctccat tgtctggaag caaatgagac aatatgagaa 1854061 cagacggata acaacttcat aagaggagga gtacacatgc cattattgcg ttttgatgta 1854121 attgagggcc gtgatgaaaa atcgctgcaa ttgttattag atactgctca ccaagcgatg 1854181 gttgaagcat ttggtgttcc ggaaagagac cgttatcaaa ttgtccatca gcatcccgca 1854241 aacgagctta taatccagga tgcgggatta gggtttcaga gaaccaagga tatggtcatc 1854301 attagcatga caagcaaagc aagaaccgaa agccaaaagg aaaaattgta tgctctgctt 1854361 gctgaaaggc tagaaaaaaa atgcgaaatt tcccctgacg acctcatggt atctattact 1854421 gagaatggtg acgcagactg gagtttcggt ctcggtgagg cgcaattttt gaatggaaaa 1854481 ctataagatt tcgtctcccc acaaaaaaaa gaagagagag ctccaaagaa gctctctctt 1854541 ttttcataaa tgcggaagtc atcagtatag aagcatccag caatacgaaa aacctggatc 1854601 tccttttata tccggtttaa atgccaattg gaagctgact gggttttggc tgaaaatata 1854661 aaattttgct gatttgcata ataagataca tcataatccc catttacaat aggttggatg 1854721 ttatagctta ttgatcattt cctattttat atatcccctt catatgcaca tgacattttt 1854781 gccaatccgg aaatatcagt ctgacaaata taaaaagtca tgtaaacggg tgtgaaccgt 1854841 acttacatga ctcaccatgg aaacaaaggc tctttttcag gtgccgcttt ccttatttct 1854901 cttcttcaca cactgtgtca ccaggctcgc aaaattgatc ggcccatgcc tgcatttctt 1854961 gaaatacagc ttgaagcgct gttccttttt cagtcagcgt gtagatgact ttgaccggcg 1855021 tttcagggag aacctgccgt tcgacaatct cgttttgttc aagctccttc aagcgctctg 1855081 ccaacatttt ttggctgatc atcggtattg tttccgttat ctctttaaac cgtttcggcc 1855141 catccattag cacatggatg atcagaccgt tccatcgttt tcccagcaat gagaatgcgg 1855201 attccatttt agggcacatc gtatttccca taagtcttca tcccttcatc tattgattga 1855261 catgtattca atgatccatt acaataatct ttcaagttac atttagtaag cttctaactt 1855321 ttctattatc ataccacgtt tatccgaagg aggaaacact atgacgaata ctctggatgt 1855381 tttaaaagca cgtgcatctg taaaggaata tgatacaaat gccccgatct ctaaggagga 1855441 gctgactgag ctattagacc ttgccactaa agcgccttct gcttggaacc ttcagcattg 1855501 gcattttaca gtattccaca gcgatgaatc aaaagcggag cttcttcctg tagcgtataa 1855561 tcaaaaacaa atcgttgagt cttctgctgt tgttgccatt ttaggcgatt taaaggcaaa 1855621 tgaaaacggt gaagaagttt atgctgaatt agcaagccaa ggctatatta cggatgaaat 1855681 caaacaaaca ttgctcggcc aaatcaacgg tgcttaccaa agcgagcaat tcgcacgtga 1855741 ttccgctttc ttaaatgctt ctttagctgc tatgcagctt atgattgccg caaaagcaaa 1855801 aggttatgac acttgcgcaa tcggcggatt taacaaagag cagttccaaa agcaatttga 1855861 tatcagtgag cgctatgttc cggttatgct tatttcaatc ggcaaagcag tgaagcctgc 1855921 gcatcaaagc aaccgtctgc cgctttcaaa agtatcaact tggctgtaag gatatgaaaa 1855981 accttagtcc gaaatccgga ctaaggtttt tttatacaat cgcctctttg taccattcac 1856041 gagcctgttc agcttcatgc tgagtcagct gatggccccc gtcctgccag taaacggagg 1856101 ctgatgcccc gctgtcacgc aaatagcggt aaagctcttc tgattcttcc ttcgtgcaaa 1856161 gaggatcgta tttcccggca ccgataaaaa cagggagccc cgccatatca ggcagctcga 1856221 taccccgaat cggaaccatt ggatgatgca gaatagcccc ttttaacaca tctttataat 1856281 gaaaaagcag gcttgccgca atgtttgcgc cgtttgaata accgactgca atcactcggc 1856341 cgcgattaaa ctgatgcgtt tctgcagcct cgtcgataaa atctttcaat tctcttgtcc 1856401 gcaccacaag atccttttca tcaaaaactc cttcactcag acgtttgaaa aatcgcggca 1856461 ttccattttc aagcaccgat cctctgacac caagcaaatg ggcatcaggg tctataaacc 1856521 gccccaatga aagcagatcg tgttcattac cacccgtgcc atgcaacagc aaaagtacgt 1856581 tgtcagatgt tcctttctca taaatatgct tcattataaa ttcccccttt taaagttcag 1856641 gtaaaatgtc tgtaatttgt tgtctatgtt tctccagcca ttcaggcagt tttaaggaag 1856701 tccctagctc agcaaacgtt tcatctgtca taaagcccgg ttcatctgtg gcaatttcaa 1856761 ataagatacc gcctttctcc ctaaaataaa ctgatgtaaa gtattccctg tcgagaattt 1856821 ctgacgaagg cagatggttt tcagcaataa tcggcagcca tttcgcctgt tcctttttct 1856881 tagtccgaaa cgctacatgg tgtaccgtac catatcctcc gactcctctt ttttcaggat 1856941 gtaaatggac atcaatgaca ccgccgaccg ccgctgaaga tgccagtctg acaatctggt 1857001 cttcttcggc cactttggtg tatccaaagc tttccgttaa caattgtatg gtcgcctgcg 1857061 ggtcgtagga atatagcagc acacctttca ttcccgtaat tgcttcattt gttgtgatcc 1857121 cgtcaggcgt ccactcgctt ttgccgcttt tcgcatcctc catgatcgcc agcggaaggt 1857181 cttctgtatc atcaaaaata agaccttttt caccaaacaa cgttttttcc tctaggctca 1857241 gcccgctttt ctcaagacgt tccttccaaa aagacaggga gcctgaggga actgaaaagt 1857301 acacccggcc cgcttggcct tttcctaccg ttccctgtcc gcttccttgg aacggaaaaa 1857361 aggtcattat tgtaccggga tctccgtttt gattcccaaa gtaaaaatga tacgttccgg 1857421 gatcatcaaa gtttactgtt tttttaacga gcctgagccc aagcacttct gtataaaatc 1857481 gcaagttttc ttgcggatct ctggcgaatg ctgtgacatg gtgcaatcct tctgttttca 1857541 ttttctcact cctatttatc tcgatttcaa gatatttatt attttaaacc tttattgaaa 1857601 aggatgcaaa ccatgtgttt tgattaaata attgaaaaaa tcattttttt ctaataatta 1857661 tcttgtgatc ttttcttaca actgctatta tagtgagcat tatcatgttt caggaggaaa 1857721 gtaaatggtt aaaaaagcac ttattgttat tctcattctt ttgccattcg ttcagctcgc 1857781 gcttttgccg cttgtgaatc gaatagaacc gattatgttc ggcctgccgt ttttccactt 1857841 ttggctgctg ctgtggatta ttgttacgcc gttatgctcg tttggcattt atcagatgca 1857901 aaaaaaagat ggaggacttg aataatgcaa gggaatctga ctgcacttct cattactgct 1857961 attattgttt taaccgttgt ctgtatcggc tttctcgccg gaagagacaa atcctcacgt 1858021 acttctgtgg aagaatggtc tgtcggcggc agacgcttcg gcggtcttct cgtctggttt 1858081 ttagtaggcg ctgaccttta tacggcctat actttcttag ggttgaccag tactgctttt 1858141 acaggcggaa gtgttgcatt tttcgccatt ccttattctg tgttggccta ctttatcgcc 1858201 tacttcttct tgccaaaact ttggaaagtt gcgaaaattc ataaattaac aacactcgcg 1858261 gattatgccc gggaacgttt taacagtaag cttttggcaa gcctcgttgc catcgttggg 1858321 gtactcatgc ttattccgta catatgcctt cagctgagcg gcattcaaga cacgcttcag 1858381 gttgccggca ctggctatat taacgtaaaa ttcgttgtga tcatttcatt tattcttgtt 1858441 gctctttaca cattcttcag cgggattaaa gggcccacat atacagccat cattaaggac 1858501 attttagtat gggtcattat gctgtttatg gtggtgtccc tccctctcat tcattttaac 1858561 ggctggacgc caatgattga cacgttagtg aaggaagcgc cgcaaatgct gacgataccg 1858621 tcagaagggc caaaaggcat tccttggttt atcacagcat ctattgtttc cgctctggca 1858681 ctttttatgt gggcacatgc cgctacaggt gttttcacgg cgaaaagcgc tgatgcagta 1858741 agaaaaaaca gcatgttttt gccgctttat aatatcgtgt taattttggt tatttttctt 1858801 ggctttatcg cctttcttgt tctgccggaa gatacaaatc caaggctggc gctgctgcat 1858861 ttgattcaaa catcttacgg cggcgtggca caaggctttg catatgccac tatcgctctt 1858921 gcttcattaa taccttgttc cattatggca atcggcgcat cgaatttatt cgccaacaac 1858981 ctataccggg atttgattca tccgaatgtg tcgcaaagca agctgactct tgtcacacgt 1859041 tcaatggtgt ttgttgtcat cggtcttgcg ctgctgtttg gaatgctgtt cccgactgcc 1859101 ttagtgacac ttcagctatt aggtgtatcc ggtatggtgc aaatcttccc tgcgattgct 1859161 gtcagcctgt tctggaaaaa ccaaacgaaa gaagcaacgg ttatcggatt attagccggc 1859221 ctagcggtaa cgtttattgt gtatatcact caatccgcac atggcattta tgaaggattc 1859281 tggggattgg ccgccaacat gatcgctgtg gtcatcctga atccgctgtt cgttaaaaac 1859341 gcgggatcca atcctgtcat tgaaggttta tttggcaaaa aacaagacgc taatccaaat 1859401 caaaagggcg cataaaaaaa ccatacgcgg cagccgcgta tggttttttt tacatttctt 1859461 ttttcagtgt ttcaattgcc ttttccattt gcgtatcatt atcagacagc ttcttttgaa 1859521 gttctatcat taatttcgtt gttgtatcgc cagtcagtat gcctgtttca ttcagcttct 1859581 cttttttctg gaactgtttg acgacagata caaaatcctg gtcatacata ctgttaacct 1859641 ttaccttgta accaagtgct ttgagcattt tctgagccac tttgacgttt gtgcctgtat 1859701 cacctgattt gtacgtttta tctgcgtcca aatacggcag cttcgcgtaa tcaggcagct 1859761 ctgctttcac ttgaggcttg atgccttttt tgtgaatcca ttcgccatca gcagtcagcc 1859821 atttggcaac tgtcagtttg acggtagagc catcatcata ttcttttgcc gtttgtactg 1859881 tacctttgcc gaatgtcgtc tcgccgatta acggtacgtt tgacgattca tgaagggcag 1859941 cggccataat ttcggctgcg cttgctgtac cgtcatttac taaaacgacg gtcggcttgg 1860001 tcactttccg ttctttttcg gccttcatga cttcttttga accgtttttg tattcaacct 1860061 gcatgatgtt tttcccttta tcaatgaaca ggttgctcat cgtaatcgcc tgttccatta 1860121 agccgcccgg gttgcctctc aagtctaaaa tatagccttt ggcgcctttt ttctctaaac 1860181 tgtcaatcgc atctgtcagc tctttagctg ttgtttcaga gaaagaagtg atttgaattt 1860241 ctccgatgtt gttgtctttc atctctgaat agacagtctc tacaggaatg gtatcgcgct 1860301 taatggaaag atcgatattc cccactcccg ctctgttcag ttcaagcttc acctttgtgc 1860361 cctttttgcc tcggattaaa gcgacggctt catttacatt catgcctttt acgctttttc 1860421 catttacctt aatgatttgg tccctcggtt tgataccggc tttttcagca ggtgaacctt 1860481 taattgggga tacaataagg atttctccgt ctttctcctc tacttgggct ccgattcctt 1860541 caaaagatgc tgaaatcgtc tcgtcgaatg atttcgcttg ctcttgatcc atatatgtag 1860601 aatacggatc atccagtgat tgaatcattc ctttaattgc tccgtctact aatttgtcat 1860661 catctgtttt ttggtaataa tcacttttga tttgctcata cgctttattt aatttgtcga 1860721 acttgctgtc tcctgtgctt gctgattttt ggcccaggat actggaattg cccgtaataa 1860781 ataaagtaag cgccgaagcg acaactgcag tgatcagcac aataaaaaac agttttaatt 1860841 gccgtttcaa ttaaacacca cctttttctt cttacattat tatcatggac gaattcttat 1860901 tcgtcaactc ggagcagaaa tgaaagagaa acgcccttct tttgcttttc ataaacctat 1860961 gtctttatac gacatatgat aaggaaaaag gaggattcga tattgagccg atatttagaa 1861021 atgctgtcct tattcggtgt cgcaggggcg cacccaggcg ggctggcttt ttcaaaagcg 1861081 gtcttgcaaa aggctgcacc ctctccggat cagccgattc ttgatgccgg atgcggaaca 1861141 gggcaaacgg cggcttattt aggacatttg ctgtatcctg taacagtcgt tgataaagat 1861201 cctattatgc ttgagaaagc gaaaaaaaga tttgcgaatg aagggcttgc catccctgca 1861261 tatcaggcgg agctggaaca tctcccgttt tcttctgagt ccttttcctg cgtcctgtca 1861321 gaatcggtcc tcagtttttc acgcctgaca tcctctcttc aagaaatttc aagagtttta 1861381 aaacccagcg ggatgctgat tggtatcgaa gctgctttaa aaaaaccaat gccccctgca 1861441 gaaaagaagc aaatgatgga tttttacgga tttacttgct tacatgaaga aagcgaatgg 1861501 cataaactcc taagatccta tggctttcaa aaaacagaag cgatgtcact tcttccggaa 1861561 gacatggaat ttgaaccaac cacagaaatg gatttatcgc aaacgattga tcccatctat 1861621 tacgatacgc ttcaaacaca ttatcagctc atgcagttat atagtgagta catgggtcat 1861681 tgtattttta tcgcgtacaa gtaaaacggc gtatcgcccc ctgttttcgt ccaacctttt 1861741 tttcctatct atcatatgct gatagaaagt caggatagga ggggaacaat attggagaga 1861801 tattatcatc tttgcaaaaa ccatcaaggt aaagtcgtca gaattacaga gagaggcggg 1861861 agagttcacg tcggcagaat tacccgtgta acaagagaca gagtttttat agctccggtc 1861921 ggcggagggc caagaggttt cggttacgga tattggggcg gttattgggg atatggagcg 1861981 gcttacggga tttccctcgg tttaattgca ggagtggctc tggctggttt attcttctgg 1862041 taagcataga acaaatgcta gattcaccag acacaatgaa gcccgcttat ctagtgtaag 1862101 cgggcttttc attttaaatt ttcttcactt tttcaaagta ctcttcaagc gttaaatcat 1862161 tatcttggat gacctttgcg gcttttttgc ctacatagcg cagatgccat ggctcatatt 1862221 catatttcgt gatatcttct ttatttttcg gatagcgaat aataaagcca tatttataag 1862281 cattgtcctg cacccatttc ccgtctgccg tgcttccgaa cgcttcattt agctcaaagc 1862341 cattgctccg gctcgaaatg tccatcgcaa ggcctgtttg atgctcgctt tcacccgggt 1862401 aagcgaccgc ttcctttgcc ttcctttccc cttttaggct tacttcattg tcaaaaatga 1862461 ctttctgtct gtcatacgaa cggtaccctg agacagctgc cagttcatag ccttcctttt 1862521 tggcagcatc gaacattgtt tttaatgcgt cggccgcttc ttttctgatg taacgttttt 1862581 gaatcttttc ttcaaaagaa aactctacat caggtatgac aagatcgcta ggttcatagt 1862641 ttccgggcag tgcatattgt ttattgacaa gcgcgagtat attttctgga ttttgaatgg 1862701 tttccagacc atcgactttt ttaatatcat tgaaatactg gctttccaat gaaaactcac 1862761 tgttttgagt gtttgatttt ttgctgtcag ctgttttttg ttctgtttgc tttgtttctg 1862821 ctgtggtttt cgtatccttt tgagcatctc cgttcgacat gctgcagccg gctccgacta 1862881 ttgccgttac actcagagcg gcagccagtg agaaccattt accggacttt ttcatattac 1862941 attaccttcc ttttatcaat cgtttccgca tgcataaaga agaggctgcc ggcacccagc 1863001 acgcctcttg atatatttta ttgtgatacg gaatgtaaag ccacttctat catatcatga 1863061 aatgtcgttt gacgctcttc cgctgtcgtt tcttctcctg ttaatacgtg atcactcacg 1863121 gtgagaattg acagggcttt tcttccgtgc ttcgctgcta atgtatacaa tgcagttgtt 1863181 tccatttcaa cgccaagcac accgtatttt gcaagttttt caatttgcga atcgtcattg 1863241 tagaactggt cagctgtaaa tacgcttcct acagtcaccg gcacaccttt atcctttgcg 1863301 gcatcatagg cattttttaa aagctcgaaa tctgcgcaag gcgcaaaatc aacgcttccg 1863361 aaagcaactc tgttcatttg tgaatcagtt gaggaggtca tcgccaaaat gacgtctcgc 1863421 actttgacat ctttacgaat agcgccgcag gaaccgactc ttattagatt ttgcacatcg 1863481 tagctttgaa ttaattcatt cacataaatt gaaatagacg gaactcccat tcccgtgcct 1863541 tgtactgaga tttttttacc tttatatgta cccgtaaatc catacatgcc tctgacttca 1863601 ttgtagcatt ctacattttc aagatacgtt tctgcaataa attttgctct gagaggatct 1863661 cccggcaaaa gcacagtatc cgcaatttgt cctttttcag cacctatatg tacactcatc 1863721 tcatatcctc ctgtaaatct aaattatcat ccagcccgtc cattttacaa cgaatgtcat 1863781 gatgaaacaa acttcagcat tgattataaa ggaatatatc gaaaaaagaa atgttcgagg 1863841 atctgttagg cacttcctca gaaaaacgga taatcggggt gttaatttga aaacctaacc 1863901 gcaggaagga ggggtgggac atgggtaaaa aacatcgtaa ccggatcacc ggccaaaaaa 1863961 agaacaatca tatacctgaa aaagatatca ttgcagctga agaagcacac gggaaagaat 1864021 attccgctgc caaacgcaag ccttaaaact gcagaaaact gcgggtttcc gcagttttct 1864081 tttcattatg tcgtttgtac aatcagacga ttgattttcc tccagccggc gggaagcagt 1864141 tgataatatg ttttcccttt tctgccttca tcaatcagga tcacgtcccc tgtggccatg 1864201 aatcttgcat cataatcact cggaacagtg tcgaatacat taaacaaaga gaatgctctt 1864261 ttcagcacgt cttgatgatc gctcccgttc agttcagttc gatagacggc tctgtagccc 1864321 tttttttcgc caaaccgggg tgtctgaaat attgtcacgt cataggaaca agacttcttt 1864381 ttaaacacgg ataacatcat caagatcccc tcccttttat ttctttaaca tattggcgtt 1864441 tttgctgtgt tttcctctct ctatttttgt cgaaaccgct taatcttttc gtcaaaacct 1864501 tttactagga aaaacagaag caagccgagg ctaaagcctc ctaacacgtc tgtcacaaaa 1864561 tgaaccccca gatacactct gcttatgccg actaaaacag caattacacc ggctatgata 1864621 tataccattt ttttatgctt agacaaaaac gggagatgtt tcactaaaaa gtaagcaata 1864681 acaggataga cacaagcagc attcatggaa tggccgctcg gaaaactgaa ggatgattca 1864741 tgaaccagcg gtgcaaaatc aggcctcact ctttcgatcc attcttttaa gactttgttt 1864801 aacagccgat ctgtgccgaa tactaagagc atcaacaggc cgtcccatgt ttttctgtag 1864861 aaaaacatgc ctgctccaat gatgacaatt agagggagca gaaaagaaga agcaccaaga 1864921 tgcgtgatcc ccgtcatgac ttcattaagc catggctgac ggatcaaaac agctgccttg 1864981 cttattgctt catctgcaga ttgaacagca tttgtatgaa tggccgcagc tagaattaaa 1865041 aagaaaagaa acaaactaac gggcttgtac aattttaacc acctcaattt tcacagaagt 1865101 catagaacat gaataataaa accggagctg accgctccgg ttttaagcct cactcatctt 1865161 catccagctc ttcatctatc atacattttt ctatcaaata atcaaaggta atatcagcga 1865221 tttcaaacag ctcatcctca ctcggtatgt agccccgtct tgcaagctct ctgtaaaaaa 1865281 attcagcgat ttcttccgta tcaatcacaa gatctatttc tttcatctcc gtaccgcctc 1865341 cttttttatg ttttatgaaa aaacaggctg aattataccc ggtgttctaa acaattcttt 1865401 cagtcatata ttgaataaaa aacgagccat gggaggctga cgctatgatt gctaaaatga 1865461 tggaagcact ggacggagaa agatttgata tcataatgga aaaaacgctc aaaggaatga 1865521 cgcgtgtgat gatttggggc tgtctgccat attttttata tgtcttgatc cgtatgttca 1865581 caaattaact gaaatgctct tttaaacttt ccaaaacaaa catcatcatg tctttatatt 1865641 cttcatcctg aaacatttcg tacagaattt tgtagtcatt ataaatatcc agaagctcat 1865701 caacaattga cacagcaagg atgtgaaggg tatcttgatc ttcatcaccg ccttcaaact 1865761 gaagaagagc agacgatgcg atatcttcgc cgatctcatg gccagtttct ccgacataat 1865821 ggacaaacaa cagctgatgc acaaactggt ccatttcata ttttctaagc accagcgtga 1865881 gatcctcttc ctccgtttca agccactctc catcctttaa acgggtcagc tcataaatga 1865941 tatcttccca gccatcttct aaatatctcc aaatttctgt tctatggccg ataatgcgaa 1866001 agagttcttt tccataatct ttaacataaa caacgtcccc aataaggaat tcatactcaa 1866061 tatcaagctt ctccatgtcg acaatgacac cctcataatc tttataaagc tgaatagatg 1866121 attcaaagta taaaacttcg ttatgattga cttcataaag atagtgttta tcaatttggt 1866181 gtacttttgt gatggtgccg actgttccat acataatgac gactacgata tcccctactt 1866241 ggaatttcgg tttattttgc ttcatggtgt ctccccctcg ccgcaacatt tctcatacgc 1866301 tatcgtatgc cgggtgaagc caattcgcat gggcatgaaa accaaaggaa atatccaatt 1866361 atggtatggg tatggacata aaaaaatccg cagtgatctg cggatgaaac agctattatc 1866421 tgccgtgcac ttcagactcg tattgatccc aagcttcatc aaacgtcgcc atcgtgtgaa 1866481 ggtaatcagc attcagctcc aaatatgaac tgatttcatg ataatcggtt gatgtttttg 1866541 gaaagctgtg atcctcatac gcctgattgg caaattcact gatgctgtcc ttcggcttag 1866601 ggtgtctgta tttcaataaa tagtgataaa aggatttcat gggtttcccc tcctgatgtc 1866661 tgtcttttgt tgttctatta tacagttcaa gtgtaaaatt acaacaaaag aatactgaaa 1866721 catgactcag gagaagtcaa aatagttgcg tttcaaaatt ctttctgtct ccatgagctg 1866781 ctgatatgtc aggctttcag gcagtttttt tgtttgaatt aaaagcagct gatcctcaat 1866841 ctctttaacc gtgttttcct cttgataggt cataccgcag gaagaacata ccatggcagg 1866901 ggtgtctgtc agttctatag ccctcgttcc atcagggagc tcccagtaca ccgtgttcct 1866961 gccgggcacc gcttcgagct cgccgcacca ttcgcatgtt ttcatgaaga atcccctccg 1867021 cattcagtct ctttctgttt tttctgctgc gccaaaaatt tcttttcttt gagctgatct 1867081 cttttctcac gccgatcttt taatgtttca tgctccggat ttgcgatgta tgcctctctc 1867141 cttttgattc tgtctacatt ttcaggtgta aacgaaactt ctttgtcagc aaaaatggca 1867201 ctcagcccga tcggctcctt tttgtcagcg gtttcaggga aaacggactc aaaataggcg 1867261 tctgcctgat tggggatata attctctggt tccggatatg acgtaatcac accttcaaaa 1867321 tttcttaaga tcactttgtc aggactttgt gacaggacat agtttggctg cagggcgatt 1867381 ttacctcctc cgcctggtgc gtcaacgaca aaggtaggaa ccgcatagcc tgaggtatga 1867441 cctctcagcc cttcaatgat ctccaaacct ttggaaacag gagctctgaa atgccctatt 1867501 ccttctgaca gatcacattg gtaaatataa taaggacgga ctctgatttt taccaagtca 1867561 tgcatgagct ttttcataat tggaaccgaa tcattaatac ctgctaatac gacagcctga 1867621 tttccgaccg gcactcccgc gttcaccagc ttttcacatg cctcaacgga ttcttctgtc 1867681 atttcgatgc ttgtgttaaa atgggtgttc agccagaccg gatgatattt tttcaatatc 1867741 tcgcacagat gatcggtaat gcgctgcgga aagacgacgg gagctcttgt tccgattctg 1867801 atgacttcca gatgcggaat gctgcgcagc tcttttaaaa tatattctaa aatttggtcg 1867861 ttgatgagca gcccatcacc gcctgaaatt aaacaatcgc ggatttcggg tgtttcccgg 1867921 atataagcaa ttgcagcatc aagctgtttt ttggggacgc ccattccgat ttgtccggaa 1867981 aagcgccttc ttgtgcagta gcggcagtac atggaacatt gattcgtgac aagaaacagc 1868041 acacggtcgg gatagcggtg tgtcagaccg ggtaccggtg aatcttcatc ctcatgaagc 1868101 gggtcttcca gatcgtattt tgttttgtgc atttcttcag aaagcggcac agactgcatg 1868161 cgtaccgggc atctcggatt gtcggggtcc attaaagaag catagtaagg tgtaatattt 1868221 aaggggatcg ttttggtaga aattctgacg ccttcctctt catcctcggt cagattaatg 1868281 actttcttta aatcatctaa cgttcttaca gtgtgtgtca gctgccaaag ccaatcgttc 1868341 catttctctt ccggaacgtc cttccataac tcgatctcct tccaatgccg tttcggttta 1868401 taccatttgt ttttcaaacg aactcctcct cgcgcatatt ttgacttaca gttgcttgca 1868461 ccaaatattc atgttttcaa ggccttcggc tataaagcaa ttattgatca gccttccgcc 1868521 atactgataa cctgaatggt acaacacagc attcatccca aaagacgaag cacgggcgag 1868581 agaaaacaca tgaacgatat cctctccagc catttctttt tctaacgcct cgattaaaaa 1868641 gcttgttaac gaatggccgc gatattccgg cagcacagcg caatcggtta tttctgcatg 1868701 cccaagctct ggattgattt ctgcgcttgc tgcgctgatc aggcggtcat gatcaagcat 1868761 gatataatac accgtatttg cattcatcgt cttttcaata taagcggggt caaataccgg 1868821 ggttgggtac gtgcggaata cttttttata cagcatcgat agctggtaca tgtcgtttgt 1868881 ttctgctttt ctcatcgtaa aaacgggtgt actgtcgttg cgaagacggg gcgctgtgcg 1868941 atatatggct tcgatgatct cctgttcctc tgtataagaa tctgtttgtc tccggctttc 1869001 tgaaaggtaa cgtaccatga cacaagccga atggccgaga taatagccct ttagatagcc 1869061 ctccggcgca aataattgtt tggcaaggat cggctcatca tgctgcttcg catagacaat 1869121 gattttttct gcattctctt cttttgccgc tgccacgata tccggcaggg ccttctcaat 1869181 ggctccgtca taacgaacca ctctgattcg tttattaaag ccgtcatggt ccaaaactgc 1869241 tgtgacaccg ctactcttta ttgacttgag catccgcatc ctccccatct gtatgaaggc 1869301 cgcaccaatc catgacaaaa agtgcaataa ttttagcaga ttctatcatg gcttcaacct 1869361 caatgtattc attggcctga tgagccgttt ttgtttcccc cggcccgaaa acgatcactg 1869421 gtgtatctcc tgcatggtac aaaagccctc catccgttcc ccacggggaa gcctcaataa 1869481 tcggctctgt ctgtttcatt ttttgatagg ctgattgcag cacagaaatt aaagggtgat 1869541 catcaggtaa atcattcggc agccattgag cgccaaacca ttcgacttgt acgggatggc 1869601 gtttaaacca ttcgtcatgg tattctaaat ccttcagcca gttttccaat tcaagtttta 1869661 cagcttctgg tttctcatgg ggagcaattc cgcatctccc ttctatgacg acacggtctg 1869721 caactgaaga tggccaggca ccgcctgaga tggtgccgat attcaccggt accggtattg 1869781 ggatattgtc atacagcgga tctgaaattc tcgcattgcg gactttctcc agctcttgta 1869841 tcgctgtgat aacgtgcatg cttttttcaa tcgcgcttac cccttcatag cgtgtgcccc 1869901 catgtgcgga taatcccttc acagtgatcc gaaaccacat cgaaccctgc tgcttaataa 1869961 atagtttcat attcgtcggt tcaggaatca gcgccccgtc agcacgatag cctctcatga 1870021 tggcggaaag tgtaccggcg ccgccgcact cttcatctac aacactctga aacaatacat 1870081 ctcccttcag tttgacatcg caggcgtgca gggcttctaa agcaaaaaga agggctgtat 1870141 tgcctccctt catatccgtt gagccgcggc cgtatatttt accgttttct tcgacagctt 1870201 gatacggttc atacttccaa tcctttacgc ttccttcagg cacaacatcg atatggccgt 1870261 tcaaaatcag ggacctgcct ccgccggctc ccgttttttt agccacgata ttcgggctct 1870321 catgaaaatc ggatcggtta gatttaaagt agggatgctg ttttaattgc tttatgcttg 1870381 gctcccatac atcaatgtcc atatgaaatt gccgcagctt ttcaagcaca acagcttggg 1870441 cgttaaactc tgaccccaat gtgctttttt ccccaatcag ccttttgaga agacgaatgg 1870501 ctttggccga atgctgatca agccactcga ttacttttct ttcaatgtct tgcatcctca 1870561 ttccccctct taagaaaaag gcatatctat tttgatttca gcttctgtca gcctcgtcac 1870621 ctcatcgatt gtcgagccat tcatcagctc ttttaaaatg aagtgatggc tatcgacctc 1870681 aagaaccgct ttttcggtaa taatcaaatc tacacagcct gcagcagtta atggcagcgt 1870741 acatctttct gttaatttag gccttccctt ttgatctgta tgactcatga cgacaaccac 1870801 ttttttcgct ttttgggcaa gctccatcgc cccgcccata ccaggcacct tttttcccgg 1870861 aacaagccaa tttgccaaat ctcctgattg gctcacctgc agggcgccta aaatcgtaat 1870921 gtcaattttg ccttttctga tcatcgcaaa agacatggtt gtatcaaaat aagaagcccc 1870981 ttttacagcg cggacaggat atcccgcggc gttgcataaa tgcgcatcct cttctccctt 1871041 ttcgggactt tctccaatgc caaggacacc gttttccgct tgaaacatga cctgcatgtc 1871101 aggcttcaaa aagttcggta ccaaggaagg gataccgata ccgagattca caatcatgcc 1871161 ctgcttaatt tcagtagcag cgcgttttgc aatctgttct ctttctgcta ctcccaagcc 1871221 catttccact tcactccctc gcttcgtaca accccctcaa caaaaacccc cggtgtgaca 1871281 atcatttctt cagaaatctc ccccatcgga acgatacgct cagcttcggc aaaggttctc 1871341 ctggcggcca ttgccataag cgggttcata ttgcgcgcgg ttttgtcata cgttagattg 1871401 ccgaattcat ctgcaatgta agcattgatg aaagcaaaat cagcagtcag cgcctcttca 1871461 atcaagtatc gttttcccgc cactgttacg atgtcctttt tttcgcaaac catttgatta 1871521 tcaatgccca cgtcggttaa aataccgcca agccccgctc cgccggcgcg aatccgttcc 1871581 gcaagcgttc cctgaggtga aaattgaacc tctaacgtcc cctctgtcat ctgttttccg 1871641 gctactggat tggaaccgat atgcgaggcg atcagggttt tgacccgttg attaacaata 1871701 agcgggccga ttccgatatc cgggaaaccg gcgtcattgc aaatcacagt caaatccgtt 1871761 acaccgctgt ccaatatcgc ttcaatcaat gaaggaggcg acccgactcc cccaaaaccg 1871821 ccaaacatca gaaccgatcc atcccgaaca tctgcaattg ctgtgtcaat gctgattgct 1871881 ttttgaaatg gcgccattta atgtcaatcc ttttttaagt ttttttcgac cgctgcaact 1871941 gtttctgaaa aaatagagat aagctcttcc atttcaccgt ctgaaatagt aaaaggagga 1872001 gcaataatga cagcatctcc ttctccactg tctattccag ctttggaagg ataaacaatc 1872061 agcccgcgtt ttttcgcctc gctgacaata agctgggtta tcgcctgctc tggcggaaac 1872121 actttcttcg ttttttggtc tgccacaaat tcaatgccta atagcagtcc ttttccgcgc 1872181 acctcaccta taatgccgct ttgagatgcc gcctcatcaa gcttcttctt cagcacagcg 1872241 cccttttttt ctgattgttt gatcaagccg tgctttaaca catatcgcaa aacttcaaga 1872301 gcagctttgg ctgaataggg atgtgcacta tatgtgtgac cgctcataat cacacctgac 1872361 ccttgtttta tggtttcaat aatagaatca gatacgacgg cagcagcaat aggtgcatac 1872421 cccgcaccga gtcccttccc cagtacagca atatcaggta cggtatccca atgctctgtc 1872481 gcgagcatcc ttcctgttct cccaagcccc gtcatcactt catctgcaat aaaaagcaca 1872541 tcgtgtgtgc ggcatacctc acttaatctc tcataatatc ccggaggcgg agtaatcgct 1872601 gctcctgcag caccaataat aggctcagcc acaaagccgg cgatgaattg gcttccgatt 1872661 cttttaatca tggtgtccag ttcatcagct gcagtctgaa caaagtcttc ttccgtctcg 1872721 tgattcagcc gataaatatg tggagctgag atagctggat accgctcaat gagatgggtg 1872781 aaccggtatc tcctttcata aaaaccagac aatgaaagcg ctcccaaagt tattccgtgg 1872841 taactgctcc atcgagacaa aaagatggat ttttgtgttt gctttttttc ctgccaatac 1872901 tgaatggcga ttttcatagc tgtttctatc gcttctgatc cgctgttgac aaaaaaagac 1872961 caattcacat ctccgggcag ctcctgtgcc aagagagcgg ctaattgctc ggcgggctca 1873021 ctcgtaaact gtgagcggta agcaaaagac acctgatcaa gctgttcttt cagcttctca 1873081 gtcacatcac gaactccgtg gccgatatta catgtcaccg cacctgacga gccgtcgaga 1873141 tatttttttc cggtctgatc ataaacatat gaacccttcg cataactgac aaccggatag 1873201 gccgagctaa gctctggctt aatcaaataa ctgctcatgc tcccacctca aaaccccttt 1873261 taccatattg tatgagtgtc caaatggcgg catgacgttc cccgcaaaaa ctttttcaca 1873321 taaaaagagc cttcctaata aggaaggctc ttttgaaatt tcagcatcta gcaaataaaa 1873381 gcggctccaa caataattaa taaaatgaac aagacaacaa ttaacacaaa tgtatttgtc 1873441 ccgcagccaa atccgtaacc gtacccagag tatccataca tgctgttttc atcctttctt 1873501 atcacgatat acgacatttt atgcgggcca agtcccaaat ggtttgtgca aacgcctatt 1873561 tcatgtaagg aaataatgaa atacagtatg cacccgctca tattttttaa acgtcagctt 1873621 ttcgtaaaac tgagttgcac cgtcagtgct tgcagccact aagtaggctg cttccattcc 1873681 tagtgatttg gcgatggaca gcatttcttt cactaagata ctgccgtagc ccttcctttg 1873741 aaactgatct aaaattgcca cttcttcgat tttagccgtt ttctcttgat gatcgataaa 1873801 cagctcgccg cacccaatgg gaactttctg tgcctggtcg ctgtaacaaa caacaagaat 1873861 gattatatct gcttcataga aaggatattt tctttttaat ttttgttcag cgattgcttc 1873921 tccaatataa atggaatcgt aaattttcat aatagaagat ccgtcgctaa gactttttgc 1873981 cgtcccccat gcggttaaag gatgtcccat ctgccccttc cagtcactaa gcttcatgtc 1874041 atatagtagc tcatcctcga cgacaaaacc gctttttaca agtgactgct tcaaaccgag 1874101 cggaaaaaca tgctgcggcg acgcttttaa atggagataa ttcgcatcaa gcagctttgg 1874161 tacggagggt aaaaagttaa gtaaccgctc caatggaaac gtatcatgga gctgaacaaa 1874221 gttatgagaa aaaatttgcg gaagctgcgg atctctgtat acgctgtaat gatcaaacga 1874281 tgccgattca gacgttaaca atatatattg atgttccgtt tttgaataat gtcctgtcat 1874341 gaacgtctcc tttttatgac ctataccttt actctgttgc aatattcaat ttctttataa 1874401 tctcatcgta caccggataa aacggctttc caattggaaa ttgctgaata tttcggaaag 1874461 aagcggagat tggcttctga tgtaaaaaaa acttccttgt tacttgttca ctaatcgggt 1874521 gaaagacgcc gtttagaaac aaaaacggct cgcgttcgat gaaaaacaga cgtcggccag 1874581 gcggattttt gatcaattca gatcgtttcc acgtaatcgg cggcccttcc ggaagcgtct 1874641 ccatctcttc ttttccaatt gtcactatgt cttttctttg aaattgataa aattgaaacg 1874701 catactggtc cacaattcgc cttttttttc cggcttcgat ataaaatatt gcaggatggt 1874761 cagcttcctt tactaaaata taattcggaa tgtttaaaat tttgccaatc ctatattgga 1874821 ataaatatgg gtctggaaca gcgacagtcc gatttagata caaaaaaccc cacttttctc 1874881 caacaggatg ccttacaccc tgatcaaaaa aatacacatt ttgatctgaa ccttttacaa 1874941 aagagccgtc aatcaaatcg gcgggcagaa accgatatgc attttgaaat gaatctgggg 1875001 ttttataggt tgtgtctaat acttcattta tcggcagaaa tggggtaaag ttgttgagtc 1875061 tcgcccaaaa aattgcgtcg ccatgattcc aatgcttcat atcatcatcc cagtagcctc 1875121 caaatttatg gtgaatgaga ttaagtaacg aacggcgatg cataactgag caatgatcaa 1875181 cttgaaaagc ggcctgatca agcactgcat tggcatttct gtagaaatgt gagatttcct 1875241 ctcccctttc gtttacatgt acaacttttt gttttgaata gaccgcctgc gcttcaggct 1875301 tatgtgaaaa ctcttgcacc atacggctca gccgctcagg atgataaaca gtgtcgtcag 1875361 taagatagga aatgtaatcg ccgtctgcaa atgggagcgc actgttaatt aatgtggcat 1875421 aacgggctgt ttttaatcga tctgcaggat gcacgaaact gttatgatat tgaatgcgcc 1875481 ggtcatggag atacttgtga atcaccgcag ttgtttctgc attcgaatga tcatccatga 1875541 taaaaagctc ccaaagatca tgcgtttgct gtatcacgct ttcgatcgct ttttgcaaat 1875601 aatcgggttt gttgtaactt gttaaaataa tagacacttt ctctcccatc tataccgcct 1875661 cccgccgtca aacataaaaa cggctccgca gcaagcagag cctctgtcat catttaaaaa 1875721 gcaccccagc ttacaacact tgagagtgaa acatgagatc tcgtgttatt taacgggttt 1875781 tggaaaataa ccaaatcagt cagaacttct tttacgatga cattttgaag tgtatctccg 1875841 ttgatcaaat tgacttttga aaccggtacg cccagctctt ttgcaaaaac aagctggcgt 1875901 ctgaggtcag atggatttcc ttcagaagac gattgacgta tcagcagaat cagcaaaagc 1875961 aaaataaaat gcagatcatc ttggttttct tctcgatcca cttgtttctc taaatccaaa 1876021 tcatccctct cccttatcct tatctctgtt tcacaatatg tgcgacttcg atttatggta 1876081 taggctatgt ccactccatt aaaaaatcag cattttcctt aaatagatga aaaatagatc 1876141 aggtacggcg ttcgactcat accaaataac agccggaaga atatgaataa cgtgagttca 1876201 ctatcgaata ggaggtgtgt gtaatgagct ctgaaaatgc acagttaaaa aaggatttaa 1876261 ttaaagccgt tttaagccct ttatttccaa ctgcaacaga aggaggagaa aatatggata 1876321 gtaatcttaa agccttgctt gatgctgcca tcgatcaaaa agtagatgaa agtgaaacgg 1876381 ttacggcaga atctatttta gacccttctc ttccggcaag atggattttt gccagaatta 1876441 cgccaggcac tacaatcagc attgtgactg attcaggtga catgatcgga ccggttgttt 1876501 tcgttgcttt cgatcaggtt cacgggatcg tatttgtaac acaggaaagc tccgtcactc 1876561 cggcaggcca agctacaaca ttaattgatg tagacaaagt agaaagcgtt acgttctttt 1876621 cataacatcc gatgaaagtc ttgtatatcc agtcgggata cggaggaata tacagttatt 1876681 ttgatcgctg ggctgaagaa tgttttcaga acactcatac agagtatatg attgcagata 1876741 aacctgaagc agaatctttg atgaagatcg aagcgtttca gccggatttc acacttatga 1876801 tggttggaga ccgcgttcct cacgactggc tgacctggtt aaagggtaag gatatccccg 1876861 tgtatgtttg gctgaccgaa gacccatttt atatggatat cagccttcag gtaattaagc 1876921 ttgctgacgc catattaacg atagaacaaa atgcagctct ctactatcaa gagctcggct 1876981 accagaacgt ctattatgtt ccgataccag ttaaccatcg gctgtttaaa aaaatgggca 1877041 ccgaacattc ctatcattca aatctgttaa tcatcggcta tccttaccct aatcgggttc 1877101 agcttatgaa agaagcggtc catctgccat tcacggttcg ggtaatcggc aaggaatggg 1877161 gaaaatatct gcctaaaaaa gtgctcaaac agccgcatat tgatgtcgtc agcacatggg 1877221 ttccacccga acaggccgtt cattattata atggggcaga catcgtaatt aatgcgcatc 1877281 gtccctatca ttttgctttc aaccaaaata ctatgcgcat caaaaatgcc agttttaata 1877341 accgaacgtt tgatatcgct gcatgcgaag catttcaatt aacagattta cccgcggcgc 1877401 atcctttttc atccattatt tcttatcacg gcatgaacga ctttaaggaa aaagccgctt 1877461 tctatatcaa ccaccctgaa gaacggcaaa aagctgcagc agccaattat aaagagaccg 1877521 tacccgcatt tacgtttgat gagcttcctg caaaactaaa agcgattcat ctggcgcttt 1877581 cttgaaaaat cgttcattgc tatgaacgat ttttttattc atagaaaaaa gcagctgcac 1877641 aagctgcttt ctattctagc cgtcagaacg gtctttcagc ttcctcggat ttacctgttt 1877701 atgaagatca ggcatttcgc cgagatgctg tgcaatttgt tcccacgata caattttgaa 1877761 attttgattg acggcttgtc cgttatcaat attttcgccg tcctgcgcca caaaaatccc 1877821 gtacggatat tttgggccaa gtccgaaacc gagaacatca ataccatccg tgtcactagt 1877881 accgtctatc ttctcgccat ctgtaatctc aaagttggct acatagcgat ttttcccctg 1877941 ccgttcatac attgcatagc tgttatttcc ttgacttgaa gccatgagat atcctttgcc 1878001 atttggtgca taatagattg tcagtccttc aatatcagct gtcaaatgat ctcctgtcgc 1878061 acggtcaaca acctgcccct ttgaccctcc gccgggctca gcgttaaatt tccagatggc 1878121 ctcatcttcc tctgctatgt ataggtttcc gtactcatca tccgcaacaa ggccttcggt 1878181 ctgagaattc aacttaaatt cacgcacctt tttccctgtt acataaccct ttccaccatc 1878241 aacaatttca tactgctcaa attccccttg tttgcctgtc actaatgcgt aaaatgctcc 1878301 tgttttctgg ctgtgataca agctgaatcc ataaacctca gaaatattgg tggaaatagg 1878361 atggttcgga tctgtaatgc ttttcaattt tcctttatcc ccgtctattg catatacttc 1878421 aattgtattt tttccttcgg accggttgga tgcggcagca atatcaattt tttcgccgtt 1878481 caatggaaaa tcatagcgca gatcgacatt attgagcttg ccaaactcat aagaatgaag 1878541 ctgttttccg tctaaatcat acacaacgag ccctgacttc ttatttgttg taatcaactt 1878601 gcttttttcc gggtgttttt catgaaccca aatggccggg tcatctgctg catcatcgcc 1878661 agatgcgacc ggatctgtct ccgtgtgtgc agtcactttg aaatgatgtt cctcattcac 1878721 ataatgagcc gacaccgagg ttgctgtcag gctaagcaat aaacccgcgg cagtgcttag 1878781 cagcattgtt tttggaacct tcatttggta ccctcctctt ttatcactaa cactactatt 1878841 gtaaaatata tacaggtgat taccgtgagg aaaatgaacc tttttttata gggtttctga 1878901 ctcataaaca acttattccc caaagaggtg gtgagatgac tttgccagat ttacttttgc 1878961 ggagcgaaat aaaaatatgt tgaatattta gtacattatt tatttagttt tgtttttccc 1879021 tagttacgtc cgtttttcca ttttctatta aaaaagaaca ctttgtgaca tgatcattcc 1879081 cctaaatttt gttttattgg ttgctttcat taattcgatt acaaagttga acatatgatg 1879141 catggtagag aaacgagagt tggaggataa gccatgccta aacagcaaac agcagaacta 1879201 aaaccatttt tccataacaa aacagtttta gtcactggcg gaacgggttc aatcgggagt 1879261 caaattgtca aacgcctttt gatgcttaca cctaaacagg tgattgtatt cagcaaagac 1879321 gacagtaaac agtatgtcat gagccaaaag tatgcggagg ataagcggct attatttgta 1879381 cttggagatg tacgcgatca cagaagggtg aatcaggtga tgaaaggcgt cgatatcgtc 1879441 tttcacgcgg ctgcgctgaa acaggttccg acatgtgagg accatccatt tgaagcgatc 1879501 cagaccaatc tcatcggcgg acaaaatgtg gtggaagctg ccctttcaca ccgagtgcag 1879561 catgtcatta atatcagtac agataaagct gtatctcctg tgaacacaat gggtgccacc 1879621 aagctgttat ctgaaaagct gtttcatcaa gcaaaccgcc acgtccaaaa caaaggaacc 1879681 ttgttttgtt cggtccgctt tggaaatgtt ctcggttcca gaggttcggt catccccata 1879741 ttatttgaac agatgatgga gggtgaacct ctgaccatca cagacaaaaa catgaccaga 1879801 tttttcatgt caatagacga tgcagctaca ttgacattac aatcggctgc tattacaaaa 1879861 ggcggagaaa cctttatttt caaaatggaa tcactgaaac ttgaagaact gattcatggg 1879921 tttgaagaat atgcatcgca gcacgggctc ccgcggccgg ctgcagtaga agtgggcaag 1879981 cgtccaggtg aaaagcttca cgaagaatta acatctccac atgaaattga atcactgtat 1880041 gaatggggca acctttatgc gatccttcca gagccggaaa aacatcctga ctttcgcaaa 1880101 gtcaatctgc ctgggtatca atcagatcaa gccccgctca ttacgaaaga aagaattgct 1880161 cagattattg aagaattgca tcaagagaaa aaggcataaa aacaagcctg tctatccatt 1880221 aggcaggcct gtttttaaca gtttatttat taaagagatg cagatagctt tcgtatcctt 1880281 cttcttttag cttatgcttc ggaacaaacc gcagcgctgc tgaatttatg cagtaacgaa 1880341 gtccgtttgg ccccggtccg tcattaaata cgtggccaag atgagaatca gcagttcggc 1880401 ttcttacttc tgtgcgaatc atgccgtggc tcgtgtccag tttttcttcc acttcttctt 1880461 caatcggctt tgtaaagctt ggccagccgc attgggaatc aaatttatct ttggatgtaa 1880521 acaatggctt gcctgacaca atgtctacat acaacccttc ttccttatga tcccaatatt 1880581 cattttgaaa tggcggctcc gtgccgttat tttgcgttac ttcatattgc atgcgattta 1880641 atgactttat tttttcttct ttattgtacg ccatttattt agccccccaa tgctcgctga 1880701 taaatcccgc tcgtccggaa cctgtccggt agcgctgata atgtgctgga ttctttttat 1880761 aaaaatgctg atggtagcct tccgcttcat agaaaggttc agcttttaaa atgtccgtta 1880821 caatcggatc tttaaagatg ccgctttccg ccagacgttg cttggaagct tccgcaagct 1880881 ccttttgttt atcattatga taaaaaatgg ctgcgcgata ggaactgccg cgatcagcaa 1880941 attgccctcc ggcatctgtc ggatcgattt gctgccaaaa taattcaagc agtttttcat 1881001 aagggaatac atcaggatga aacgtgattt gaacggcttc acgatgtccc gtcgtttcac 1881061 tgcacacctc ttcgtacgta gggttttcag tatggccgcc tgtatacccg gacaccactt 1881121 tttcaattcc cggctgttcg tcaaaaggtt taaccataca ccaaaaacag cctcctgcaa 1881181 atgtggcgat ttcttttttt tcagacatac tggtgcctcc tttgttaata cgtggtatta 1881241 ttatattata gcatgtaaaa atagaatgaa aatgattctg cttttcaata aaatctatag 1881301 gttttaagca atatgcttat gtaatggagg ttcacaaatt tgaaagtaag aacacagatg 1881361 atgtacgata tggaaacttt actccgtaaa gtctttaaac aaatacgcaa tgaaatcaat 1881421 gaaattttag ataaagagct gtcgcggaat gaattcacca ttcttcgaat ccttagtgaa 1881481 caagggccta aaaaagtcac tgaatttgcg cctattttag aggtatcggc aagccacatt 1881541 acggctgtga ccgatgcgct ggtagaaaag gaatggatta cgagaatcag atcgaaggaa 1881601 gacagacgca tcatccgcat tcatatcact gaagcgggcg aaaaagtcct tcagcacttt 1881661 aacgagaaaa aaacggaata tttctttaaa cgctttgact gctacactga tgctgaactt 1881721 gccacgttaa tcgagctctt cagcaaactt gataaaaaac ggtgaaaaaa agcacatacc 1881781 gatatatagg tatgtgcttt tcgcagtgct tcacttattt ttcagtaaac agcttcattg 1881841 ctttccagcg gccatatcta taatacaaaa atgccgcgca gctgctaaat aaaaaactca 1881901 ttccgattcc aagcccgatt cctttttgtc caagccaagc tgaaaataga gctgtgaaag 1881961 gatacctcaa cacccaaaac gagatcaaat ttaataccag aacctgcagc atcgctcccg 1882021 cggccctgac gattccgttc agcacaaaat taaccccaat aaaagggtag aaaaacgcga 1882081 tccacttcaa atattgttca ccaaatgcga ccgcatcagg ctcactgata aataacctta 1882141 tgaggtattt accaaatacc caaatcataa ccgcaatcac cagcatgcag gaaataacag 1882201 ctatcacacc tagccttgca attgttccca ctcttttttc gtttccgatt ccaatatttt 1882261 gccctgccat actattgacg gccgtaccgg cagccattgc tggaagcgtg atgatgctat 1882321 caagccgctg caccgcgcca aagcctgata ccacgtgatc cccgtatgag ttaacaacac 1882381 tcataatcgc catcataccg cctgtaatca ccatcatctg cagacctgcc ggaatcccga 1882441 gtttcaaaat cagcgcggac tcttcccact tgggcattct cggaatcgag aatggcacaa 1882501 gcttgtgttt gatgacataa aacaacccat acaaaaacgc aatgccctgt gacaaaatcg 1882561 ttgaataagc cgctcccgct attcccatgc ggaacacaga aataaagagc ggcgcaagca 1882621 ctgtattcag tacaacagca aacgcaataa accggagagg tgtcttgctg tcgcccagcg 1882681 cacgaagcac agtactgata aagttataac caaacaaaaa taaaatgccg ataaattgaa 1882741 tctgtaaata cgtctcagca agcggtatca ttgactccgg cgtttttaga agacgcagca 1882801 aaagctctga gagaaaaaaa ccggccgcgc cgaatccgat gcttaggcct gttaataaaa 1882861 caacaaaagc gttaatatac gacgccattc cttttatatc atcttttcct ttttgctgag 1882921 ataaaatggt taacgtcgca ttgttaaggc ccaaaataaa agacagcacg gtcaaaacaa 1882981 tcgtgcttga taccgcggct gccccaaggg cctttgcccc cagtaaattg ccgatccaca 1883041 agctgtctat aaattgaaag gaaacctgca atgcgtttcc gagcataata ggcattgaaa 1883101 acagtacaag ctgtttcagc acgttcccct gtgtaaaatc gtatgctttc atcttttctc 1883161 cttgtgttct caaattttct tcggaccaca cgaaaaaaga gacgttgttt catgtctctt 1883221 ttttcatgac ttatcggttt tttttcggtc tcgcataccg aatgtaaaca ccatcacact 1883281 taggaacaag gcacaatagg aaacattcaa atacatttga tccatatctt cagcagccag 1883341 atgatgataa gcaagccagc cgaagtacag ggaaaatgta aaggataata aactgaaata 1883401 ctggtaaatc cgtttcattt tcagtcacct ctattgttta ggatggtaat aggaaaactc 1883461 aatttcatct ttttctaaat ttatcttatc cgctttgaca tacattccat tcgttaaagg 1883521 catttctgac aaacgcactt caatgctttt atctccgggg tgaacatgga caaatgacgg 1883581 caattcataa aagctgtcca tataatttaa cacaaagcta attggtatac tcaatttccc 1883641 taacgaaaat ttcgtgacat tcagctctac atcaccgttt tttttcacgg tcggctcaaa 1883701 agcgataaac gcatcaatag acgtggaaaa tgccttgatt ttccctgcga catgaacatc 1883761 atcatcaatc tctactttat aatcaagctt gtttgatgct ttgtcgttta aatatgagtt 1883821 aacaaacgca gctaatgatt cttttgtgct tgtcacttga aatccatact cgctctcaga 1883881 tgcatctttc acctgagcct gttcccccgg aagcaaaaca agtgccacaa acccggcggc 1883941 gaggataaaa ttgattgcaa gcaatataaa aaacagtcgc ttccacttat tcatgctgtc 1884001 accctactct ttcggtaatc cttctttttt aatggcttga tagacgcgct ttgcgataag 1884061 agaataaccc gtaccattag gatgaaaatc atcttcctca gaaattcggc tgctgtcact 1884121 tttttgatta aacaaatctt cgatatggac gatttttgca tgtttatctt ttttcagctc 1884181 tttttcagca atatggttcc aatccgtgac gacaccattt atttcattta gttctgataa 1884241 tgtaaacgta aacggattgt acatgctgac ataaatcagc tcagcgtgat cattcagctc 1884301 gcgaatttca gaaatgattt tttcaaagcg cttttcgtac ggtttttccg cttcctgaaa 1884361 cggttcaacg gttaattgca gaaagttttg gcgaaggatt ttcatcaaat cattaccgcc 1884421 aattgtaaaa aagacataat ctgcgtcctt tatgcctttt tgaacctttt tatcttttag 1884481 tttttctaat aaatcatccg aacggttccc ttttacagca taatttttca cgtcgaccgt 1884541 tttgacttgt ttatctgacc ggatagaatc cgccaccttg ccgacatatc cctttccgtc 1884601 gggatctccg actccttctg tcagcgaatc tccgacagcc gctatgacaa tgtgttcttt 1884661 tgttttcgtt tcatgggctt tttgttttcc ctcagatgat gtacgtatgc tcgtacacgc 1884721 agtaagaagc aaaatcaaac tggccatgat tgaaaaaatg cgcagcttca atcttgttgc 1884781 tccttcccat tctactagtg gaaagtgtat catgttttag aagatttgca aatgcctagt 1884841 ctcttagctt acttgagtgt actggctgac ttcacatcgg aaatgatatc atcgtacggt 1884901 gtattctcca ctccattgta atctttcagc accttaccgt ccggacctac caaataaaaa 1884961 gaagattgat gaatcacttg gtcctctccc tccggcttct ttacgatcgc tttaaagctc 1885021 ttaagtgcga actcctcaat ctcactctgg ctgtatcccg tgagaaaatc ccagttatca 1885081 aaagataatg gataatttgc ggcaaatttc ttcagctgtt tcggcttatc gttttctgga 1885141 tcaacactaa atgatatgat gcggacatct atattttcgg ctttcagttt tttttgcaga 1885201 tcggtcatat gagcggtcat tggcggacat atagtttcac aattggtaaa aataaaatcc 1885261 gccagccata cttctccttt taaactctct aaagaaacgt tcttgccgtc ttggttttga 1885321 aatgtaaaag gctccacctc gtaattgagc ggatctttaa tctgctgtcc tccgcatgca 1885381 cacaaaaaca gaaaaatcag cccagccgtt aaccccttga taaccttcat gacatccatc 1885441 ctttccagcc agcataaaaa cgctttctaa aaccgtcctt actgtcccat gtttgtattc 1885501 gatactgagc aaaaaaaatc ctgcatgcct ccccattaac gattacaaag gagggcatgc 1885561 aggtaaaaaa cggcatgtta cgcgttgtgc tttaacacct cttgatgaaa tacagcctga 1885621 taatctgccc acttcatccg ccgcttcata taatgtcgga aagaatacac ttttgccctg 1885681 ctgtttgatg aaaacacttc ttttaagtag aattgcaaat ggtgatgtaa cataaagaaa 1885741 tagtgctcat cttcctttaa tacaggtatt tctgtcactt tcacctgaat cccgtcaccg 1885801 cgtttgaact ctaggctttt gagtaacaag ctatcaatcc tcttttttgt ttttcttcta 1885861 ttatatatga tgccagccgg gctgtctgtc attttgcgcg gttgtgtaaa aaaattagat 1885921 tagcaaatgg aacaagtcct catccttgtt cacctctaca taatgaaacg gttttttgtt 1885981 catccgttca atcagcggcc cataatcggc tttgttctgc agctcgatgc cgacaagagc 1886041 aggtccattg cttttattat ttttcttcgt atattcaaac cttgtaatgt catcattcgg 1886101 cccgaggact tcgtcaagaa attcgcggag cgcccccgct ctttgtggaa aattgacgat 1886161 aaaataatgc tgaaggcctt caaaaatcaa ggaacgctcc ttcatttcct gcattcttcc 1886221 gatatcgtta ttgcccccgc ttaccacaca caccacgttt ttccctttaa tttgatcctt 1886281 gtacaaatca agcgctgcga cagaaagagc tccagccggt tcagcaacaa ccgcacattc 1886341 gttatataat tcaagaatgg atgtacatac ttttccttca ggcacaagga gaatgtcatc 1886401 aacgacagtt tccagcgtcc ggaaggtttc ctcgccaatt tttttaacag ccgccccatc 1886461 tacaaactta tcaattttat caagtgtgac gacatgccca gctttgtttg attcaaagta 1886521 ggatgccgct cccgccggct caacagcaat tacctttgta tcaggagaca cgtttttcaa 1886581 atatgtacct accccagaga gaaggccgcc gcctccgaca cttgcaaaaa gaaaatgcgg 1886641 ttctgtatca atgtcgttta aaatctcgac tgcgagcgtt ccctgtccgg ccatcacatc 1886701 cggatcatcg aacggatgga taaacgtccg agattccgcc tcacagcatt cagcagcgct 1886761 tttatacgcg tcgtcaaacg tatcgcctgt caaaataata tcgataaatc cttttccgaa 1886821 tagttcaact tgagatactt tttgtctcgg tgtagtagac ggcataaaaa ttttcccgtg 1886881 aatgccaaga tgtttacacg aaaatgccac accttgagcg tggtttccgg cacttgcaca 1886941 cacaactccg ttctctgtct gctcgctgga aagctgtttc attttatgat aagcccctct 1887001 gagcttaaaa gatctgacaa cttgcaagtc ttcgcgtttt aaatagatat tgcattcata 1887061 tctctcagaa agtctgtcat tcctctgcaa aggtgtgtga atgacaacgt cctttacgtt 1887121 ttggtgagcc ttcaaaatgt ctttcacttg gatgagagag ttttctttaa gcaacggttt 1887181 catgtacaga ttcctttctt gttttaaatc cctatttaat atgccattat aacatgaata 1887241 ttcaaaaaat aagacaatta tttttattta ataattaaaa aaatacagac tatgtccacc 1887301 acatcttgtg gtaacttctg ttcaaccatt atcctgcaga gccaagaaaa aagatgatcg 1887361 taaaataaag ggtgttttca accaaaaggc atgatataat gaaaccaatt agaaccaaaa 1887421 ggagccaatt gatgaatagt gcaccaaaac tcaatacatt tcaacatcta atcggagaac 1887481 atcaaacttt tctggaagcg aagcgaatcg ccaagcagtt ctcgttatcg gagcttcctg 1887541 tcttaataac aggaaaaatc ggaacaggca aaaatcactt cgcacatgcc atacacttgg 1887601 aatcttcgag aagcaatgaa ccgtttataa gcgtcaattg cagcacccat tcggaagaaa 1887661 cccttattca tgagcttttt ggccctaacg gaaacacagg tgtttttcaa aaagcggtac 1887721 gaggaaccct ttttcttgat gatgtatggc gcatgcctgc ttctgtacaa gctcagctgt 1887781 taaaagcgct tgattcagac acggagaaac cgcgaatgat ctgtgcttct gcagaccgat 1887841 ccgtggaaca tacattcagg caagacttat tctacagact gaacatttta acgctcacac 1887901 tgcccgaatt atcggaacga aaaagcgata ttccgctttt gacacagcat tttctctcaa 1887961 attctggtca gcaattgtta atcgatccct ccgtttttcc cgtgcttgag aagcatgcat 1888021 ttgaaggcaa tgtcagggaa ttaaaaaacg ctgcagatta tatggcggca gtatcaagcg 1888081 ggggaacgat tcagccatat gacctgccgc cgtatattag aggcacgata gacggaaaaa 1888141 cgtcgaagaa aaaagcgaaa ctgcttactt taatggaaaa agctgagttt ttgtttattt 1888201 tggaaacaat aaaagtattg aacgaaaaag gagaacctgc cagcagacgg atcatttctg 1888261 aacacagcaa aaatacccaa acctcgttaa ctcctcagca ggtcagaagc cgtctcgact 1888321 atttggagaa aaaagattat gtcaccaaaa gccgcggacg cgcaggcaca aaaattacct 1888381 ttgagggctt gagctttata gagacgttaa aaaatcaaat gatctagcga tcgaaaggag 1888441 aatgtacttg tttacaatca aagaagagat cgccaatgcg attacacacg gcatcggtgt 1888501 cctcttatcc atcccagcat tagtgtttct aatcatattt gcggctaatt acgggtctgc 1888561 atgggacatt gtcagcttta caatattcgg tgtctctatg ctgctgttat atttgagctc 1888621 caccctgctt cacagcatca cacataaaaa aacgaaggac attttggaga ttattgatca 1888681 tagcgcaatt tacgtactca tcgccggaac ctacacgcct tttttgcttg ggccgctgaa 1888741 aggcacactc ggctttaccc tgttggttat cgtatggtca cttgccctag gcggaatcgt 1888801 ttttaaaatt ttctttgtga aacggtttat cctattgtca accttcgtgt atttagtcat 1888861 ggggtggctg atgattattg cagttaaacc tttatatgct tcactgagcg gagcgggatt 1888921 cagcctcctt tttctcggcg gcattttata ctctgtcgga accatctttt acatttggaa 1888981 aaagatcccc ttccatcacg ccatttggca cagctttgta ttgggcggga gcgctgccat 1889041 gtttttctgc gtgctcttct attgtgtaaa ggtgcctttc ctttcgtaac agtaacagaa 1889101 aagcgcagtc ttcacgactg cgctttttta tgcacgtaat tgtttttcat tggcaggtat 1889161 ataagctttt gaaaaggaca attcaatgtc tgccggtttt aagcgtttaa aaaacgagcc 1889221 attttgcatg ttatctgttc ctttcgtttc caccatcacc aacggaagat gatagcgggc 1889281 cgcaagttct acaggatcaa tagaaccatc tagtgaaaga atcaggcttt gtcccttttc 1889341 cagctgtttt gtcacatctt catatacctt ttctgaatcc ccgtctgaaa tcacatccat 1889401 ccgatccagc cattgcccga taaaaggcaa gcggaacact tttgggttag cgataaagcc 1889461 ggccggttcc tcaatatatc cagcaattaa ggccagttca gccaaacgca aacggggatg 1889521 cacatacaaa acaggaccgt gtggtattgg ctctggctga tggatcgtca caactgaacc 1889581 ggagatgccg atacagcctt ctaaaaacgc ctttggctgt tcgtacacaa gagccatctg 1889641 ttttttgtat gacagacggg gatcgagcat tgtttgatta aataattgtt tcatattttt 1889701 taacagcata tacacaatat aaaccactag aaggctgtag cgaaccaatt aaaatcctcc 1889761 cgctttagaa gaattctttt tttcatacat tagaaattcg taatcatacg ggtttttttc 1889821 gtctttggtc ccctgctcag aagaaaccag cttccaattg gattcatcaa attcaggaaa 1889881 gtgacggtca ccctcaaact cgtgatgaat tttcgtcata tacagtctgt ccgcataagg 1889941 gaacaggtcc gtatagagct gagcccctcc gatcacaaag cattcttcag ggcctgaaca 1890001 aatgtccagt acatccttta atgaactgac aaccgtgcat ccctgaaatt ctgaatccgg 1890061 cgctgaggta acgacaatat ttttccgatt tggaagcgga cgtccgatcg attcaaatgt 1890121 tttccggccc ataatgattg aatggcccga tgttattttc ttaaagtatg caagatcatt 1890181 gggcaaatgc cacggcaaat cattgtcttt gccgataagc ctgttggcat ccatcgcaaa 1890241 aatgaatgaa atcatacgct gaccgcccct tttatatgag gatgcggatc ataatcctcg 1890301 atgataaagt cctcaaatgc aaagttaaaa atagaatcaa cctttctggc gaaacgaagc 1890361 tgcggaagcg gtctaacatc tctttccagc tgcaaattga cttgttcaat atgattttgg 1890421 taaatatgaa catcaccaaa cgtatggatg aactcgcccg gttcaagccc agtcacatga 1890481 gcaatgatca tggttaggag ggcataagat gcaatattaa acggcacacc taagaaaaca 1890541 tcggcagagc gctgatacag ctgacaggac agcttgccgt cagacacata gaattggaac 1890601 aggcaatggc acggcggcaa cgccatttta tcaatttcac caacattcca ggcgctgacg 1890661 attaagcgtc tggagttcgg atttgtttta atatcttcaa taagacggga aatttgatca 1890721 atggtttctc catcagctcc ccgccaagaa cgccattggg agccatatac aggtccaagt 1890781 tcaccgtttt catcagccca ctcattccag attcgcactc cgttttcctg cagatagcgt 1890841 acattcgtat ctccttttaa gaaccacagc agttcatgcg caattgattt aaagtggagt 1890901 tttttagtgg tgagcatcgg aaagccttcc cgtaaattaa atctcatttg atatccgaaa 1890961 gtgctgattg ttccggtccc agtccggtct ccctttttct caccatgctc taaaacatgt 1891021 ctgcagaaat ccttatactg tttcattttt ttcatccttt aaaagtagtc ttctagtagt 1891081 gtaacacaat aaaaaatcat ttctgaaccc agaaatgatt tttttatagt cagctgacga 1891141 caggcttttc atcctgttct ttttcttcat cttgcagatc ctgatgcgta tgtgcaattc 1891201 tgctcgccgc tgctgcagca agagctgcca caatatcatc caaaaaggtg tgaataccgt 1891261 ctggactttc atcaagttcc ttaataattc caatcttctc tttatccaaa taaccgaaat 1891321 tggtcaaacc gatcgacccg tacacattaa cgattgaaag cgggataatt tcatctatgc 1891381 cgtaaagcgg ttcatccgtt tcaacaaggt gctgcagcgg ttcggggaga agtttctgtt 1891441 ctgcaagctg atcgagtgca aggcctgtca aaacagcatg aataatttca cgtttgttca 1891501 ggactttttc tacattctcc atgcaaacac tgagcggcag atttggattg tatttttcct 1891561 gaagtttttg aacaatccgt gcaatatctt ctatcataac gccccgtttg ttcagcatat 1891621 cctttgttat atcgaccatt tcattcattg tgtacttttt catgtctaat ggcatctcct 1891681 ttaggcactc atccagttgg gaggcgtgtt gcggtcccag taaatgctcc caagctcatg 1891741 atgtgattga aatccatctt ctgctgtatg ataatgaaaa ttaaaccagt agccgtcatg 1891801 aggcgggtgg tctcttcgca catggaatct gagaagatct tctccagttg tccgattgta 1891861 aacgttgaaa attttttccg ttttgcccgc tgaaggcatg cttgagatca caacatcttg 1891921 gtacgcctca tcatcttgca atgtcgctaa ataatcacta atcacatttt cgatttttgg 1891981 caggatctct ttccgatagt catcctcaat gacaggagcg attctgctgc cgaattttaa 1892041 aaaggactga tcctcagcgc tgtcaaggag ctgttccttg tacgattgaa aaagcagttc 1892101 aggatctcgc ctgtcatccg actcatcatc gtacaggtca tgctcatcat aaaaagcggt 1892161 gtaatcattc tgctcaagac tgctcggctg tccggaaggc ttgtccgcca taagggcagc 1892221 cggaggagat acgagcccga acgttacaat ggtaaataaa accacaaggg tctttctcat 1892281 ccacaatttc atgactgctt attcctctct attttattgt catgtttctc ttattttagc 1892341 acatccaaaa catgcaagtc atgtactata tgaaactgat atgcaaatta ggagattcgt 1892401 tgctatgcac tttgtgtaaa aacgcttaca atatttcatg aaaggaggct ttccgcatga 1892461 ttgacgctct gtttgccaca gtttcactct taacattatt atactttgtc gtcatggagg 1892521 tcaccgatta acagaaagcc cgtgatatga atcacgggct tgtttgaatg acgccataat 1892581 ggaacagtgc tgtttttctt ttcatgacgt taaaaccaaa ctgttcaaac cgcgggcttt 1892641 tccagtggtc ttttagcaca acgctttttc tggcgactcg taccgcttca ttgatacatc 1892701 cttcgtgcaa aacggaatcc tctgccaaat cacgtaaagg cgcgatgccg tcagaggttt 1892761 ctacaggttc atgaaacatt ggatcgaaat aaaccacatc aacagagttg tcagggagct 1892821 gcttgatgtg ttcaaagcaa tcaccattct tcacctggat tcttctcatc gcagcttgaa 1892881 gctcttctat acccgtttcc catgaatgca gccccgtcct cactaaaaca gacacaagat 1892941 ggtttttttc aatcccaaca acagaacccg tttcgcctac tgccatactt gcgataatgg 1893001 catctgaccc caacccgagt gtgcaatcta aaaacgtatc cccttcagat aagccggcag 1893061 cccgaagcat aggttctttc tccccctgta agaagcgttt ggctctgaac atcgctgtat 1893121 tcggatgaaa aaagaatttg gcaccttgtt tcgtatacag ctcaaaccgc tctttgccga 1893181 ccacaagcaa atcacgttca gctgatttca gcaggtgctc aaccgtttgt ttattccggc 1893241 cgcagtatgg catatttagc tctttagaaa gctgctttgc agtttttatg gtgtgttcag 1893301 acggtctata gcttgttgtt atcatcttct gtactcccaa aaagaaaatg cccggagaac 1893361 gggcatttag cagtgcgcat cgaaggcagc agtcagattt ttcatgattt cttccatatc 1893421 gtgtccttca atttcatgac gcggaataaa atgtacgact tctttgcctt tcaaaagagc 1893481 cattgatggt gaagaaggct cctggccagt aaaatactca cgcattttcg cagtagcttc 1893541 tttatcttgg cccgcaaata cagtcaccgt attgtcaggt gttttgtcat tctggaggac 1893601 tgcctgtgta gccgcaggac gcgcaaggcc tgccgcgcag ccgcatacag agttaacgac 1893661 tacaagagtt gtgccctctg ccttttccat aaagttttct acttcttccg ctgttgttaa 1893721 ctcttcaaaa cctgctccag tcagctcgcg gcgcatcggt acgacaagct ggcgcatgta 1893781 ttcttcataa gccattgaca taaaaaaagc cccctctagt atccttcatc tgaagtaaag 1893841 gatactatag agagggccgg atttcaaatg ttcacgcctt aaaataaaag aaagtgtccc 1893901 cagctatcta gattttcata ataccgccgg tgttggcact tgtcacaagt ttagaataac 1893961 gtgccaggta gccggttttc actttcggtt caaaaccttt ccagttcgct tttcgttttt 1894021 cccactcttc ttctggcact tgtacatcca agatgcgttt ttcaatatca acgataatat 1894081 ggtctccgtt ttcaacaaag gcaagcggcc cgccctcagc ggcctcaggt gatacgtggc 1894141 cgattgagag gccacgggag gctccggaaa aacgtccgtc cgtaatcaat gccacttttg 1894201 gcccgagtcc cattccaacg atttgggatg ttggcgccag catttccggc atgccaggtc 1894261 cgccttttgg cccttcgtat ctgatgatga caacgtcgcc ttcttttact tttcggttga 1894321 taatgccgtc aagcgcctcg tcctgagaat cgaatacgac agccggccct tcgtgtcttg 1894381 taatcccatt ctgtacgccg cctgttttaa tgatagcgcc gtccggagct agattaccga 1894441 ataaaacagc aaggcctccc ttttcagtga atggttgatc cagcgggtga atgacgtcat 1894501 aatcctttac ttcatgtccg gcaatggttt ctccaagagt ttttcctgta acagtcagcg 1894561 catctaaatg aagcgctcct tctttcttcg aaagctcatt cagagccgct gaaacgccgc 1894621 ccgcttcgtg aagatcttca ataaacacat ccgatgcagg cgccagctta gccaagtgcg 1894681 gcacgcgctc agcgacttcg ttaatgcgtt ctaaagagta ttcaacgccg gcttcgtttg 1894741 caagggcaag ggtatgaaga acggtatttg tagaacctcc gagcgccata tcgagtgcaa 1894801 acgcgttatc aatcgctttt actgtaacaa tatcacgcgg tttgatatct ttgcgaatcg 1894861 tttccattaa ttgcgcagcc gattttctca caaactcttt gcgttccgga gatgttgcca 1894921 gaatggttcc attacccggc aaagcaagac caagtgcttc tgacagacag ttcattgagt 1894981 tcgccgtaaa catgcctgag caagacccgc acgttgggca tccgaactgc tctagttctt 1895041 gaagctcgtt ttcgttgatt ttccctgctt ggtaggcgcc taccccttcg aatactgagg 1895101 aaagggagat ttttcgcccg tcacttgttc ttcctgccgc catcggtccg ccgctgacaa 1895161 aaatcgtcgg aatgttgatg cgcattgccg ccataagcat tcccggtgtg attttgtcgc 1895221 agttcggaat acagaccatt ccgtcaaacc agtgtgcgga tacaaccgtt tccacagagt 1895281 ctgcgataat ttcacggctt ggcagcgaat atctcatacc gatatgcccc attgcgatgc 1895341 catcatctac cccaatggta ttaaattcaa acggaacgcc ccctgcttct ctgattgctt 1895401 cttttacgat tttcccaaac tcctgcaagt gaacatgacc gggaacgata tcaatgtatg 1895461 aattacacac cgcaataaac ggcttgccga aatcctcttc ttttacccct gctgcacgaa 1895521 gcaaactgcg gtgcggagct ctatcgattc cttgtgtgat catattactg cgtaattctg 1895581 ccatggtgat cctcctaaat tctttcaatt gtttgattgg attttatttt gacaattttc 1895641 agtttattta tgggctgttt ttgcaaataa gataaataca ggccgccctc accttgtttt 1895701 gttctttcgt gtttttatat ttatatagct ttctttcgat ttgaaccctc caactattaa 1895761 tattgttact tactataaat agttttcgga tatttttcaa caatattcga aataattttt 1895821 ataaaaagtg aattcacata aaaaaggtgc atgatctgca ccttttttat ctttattcgc 1895881 ctttttttct gctttccgtc atttgtttcc aaacagaacc ttttgcttct tctccatgct 1895941 caatacgttc aagcgccatt ttgacttgaa ggctgacctc aaattcgggg tcatcttcgg 1896001 cagcgcgcaa agcttcaatt gcactttcat cgccgacttc gtacaggaac atggcggcac 1896061 gccagcgaac aagcttgctg gagtcgctta atgacttgat catagcagga atggcttgag 1896121 gatcgccgat atcagacagg cagtctccgg ccgttcttct gactgataca gctttgtcct 1896181 caagtgcttt atacaataga ggaagaacat caggtgtttc aatcattcct aagtacacaa 1896241 cagcctgtct tctgatggac acctttggat catccaatgc cttctgtaaa accgggatat 1896301 cctcttcttt cggatccatc tgttccaagt gtgcataacg ctttttccag tcctcatcat 1896361 ccagcatatc aagcgttact ttatacgctt tgcgctgtac agcttgtttt gcttcgccct 1896421 ttccttgagc ggctgcttca gtcagtcgtt tcagccgttc atcactgtat gccgcttgaa 1896481 gctcttctgt cacatcatgg ccgatttcat caaagtcacc gaatctgaca ccttgttctt 1896541 tccaagcccg ctcaaacaca acattggaag cttcagatct aagttttaag atcgcctgct 1896601 gaaagcgttc aggtaagccg aagcgttctt cccgctctcc atcggttaat ttaacttgca 1896661 taggaatgcc gctgaacatc tgcacaaaaa cttttacctc tccaaaagat tcttgatcag 1896721 aacgattttc ttctgcgctt tcagcacttt ccatcccaaa tgcagtgcgg acttgcggta 1896781 aaatgtcttt ccagtcgtat cttgcattcc gttcaacagc aagaaaatct gcgacgtgat 1896841 ataccccttt aactccatct attttaagga tttccgctat aacaagcggt gcgccttctg 1896901 cttgctcagg tttatagtta ttgcttttgc ccgccggaag ctcttccgtt aagatgactt 1896961 tcattgtatt cgggcttggt gtaggttcaa ttgattttat cttcatgatc gtcctcctat 1897021 agcatatctg tgacttattc tatcatagtc gctccaagcc ttctattacg acgtttcggc 1897081 atcaatcccg ggtatgtctt tttctaattg gcggacaaat tgaagcataa aattgtgtct 1897141 ttcttctgcc agttcccgtg cagtgtctgt attcatcata tctttcagcc gcagcagctt 1897201 atgaaaaaaa tgagcgtagg cgctttgctc atctccataa aggccatgcc cttttgcgcc 1897261 cgcaaacatg aaagctctcg caatgccgac agcaccaatc gcatcaagtc tgtcagcatc 1897321 ctgtacagct tttccttcaa ttgagagcgg ctccttcgcc aatttccccc tgtcccgaaa 1897381 ggacatcctt gttataatat gaatcaccct gtcagcattc tcttttccta ctccgaaaaa 1897441 aacgagctga tcatatactt cgctcacaga aagcctgacc gtgtcaggca gcttcacatc 1897501 aattaaatca tgaaccaaag ccgccgtttc aacaatgaac aaatccgctt tttccttttc 1897561 tccaatatac gctgcaagat ctgctactct tgatacatga tgccagtcat gtccagagct 1897621 ttcgtcagtc aggatagatt gaacccatgt cctgatttgc tctgcctgct tcaattcctt 1897681 cacaaaaaca ccctcttttt attgctctaa tagcttcacg atatcgtctt ccaactcttt 1897741 cggatttgta tttggtgaat aacggccaac gatttctcca tttctatcca ctataaattt 1897801 cgtgaaattc cacttgatcg ccttagttcc cagcatccct ttcgcatgtt ctgtcaaata 1897861 cacaaacagc gggtgggcgt ttttcccgtt tacatccact tttgaaaaca taggaaatgt 1897921 aacaccgtaa tttgtttcac aaaattcctg tatgtcagcc tcttcaccag gctcttggtt 1897981 catgaattga ttgcagggga accctaagat ctccagcccc tcctgctgat atgtatcata 1898041 taattcctgc agctgcttca attgggaagt aaaaccgcac ttacttgctg tattcacgat 1898101 catcagtacc tttcccgcga aaggctgaag tgtcatgtct ttccctgtga ttgtacgtac 1898161 cttcatatga taaatagaca tgtaagtccc tcctatgtcc ttggtgctga ttattttacc 1898221 ttttttaaat cgcaattcaa aatgtaaaca tcaattaaga actcataaga aacctaacga 1898281 tatgagcgtc agttcattat caattcatat ggctcgtttt ttatcttatc attctataaa 1898341 acattacaat tccctcttac atctttgaaa atcattttac tgtgaaacca aaaggcgtgt 1898401 cagtgcgttt tatttaaaga gttttctgtt gtttccccct caacacgtat agatagattg 1898461 aaaattggcg tgaaaattcc tataatgaag aaaattaaac ggggaaataa tggaggtggc 1898521 acgttgccta ttaatatacc aacacacctg ccggcaaaac aggtgcttga aagtgaacat 1898581 atatttgtaa tggatgaaag cagagcattt catcaggata tccggccgca aaaaattatt 1898641 atattaaatt tgatgccgaa aaaaatccaa acagagactc agcttctcag attgcttgga 1898701 aattcgcctt tacaggttca tttcacattt ttaatcccaa gcacacacac gccgaaaaat 1898761 actgcgagag aacaccttga cgaattttac acgacttttt ccaatatccg tcacaagagg 1898821 tttgacggca tgattatcac cggtgcgccg atcgagcatt tggcgtttga agaggtttca 1898881 tattgggaag agctcaagga aatcatggag tggagcaaaa caaatgtcac ttcaaccttg 1898941 catatttgct ggggtgctca agcaggtttg tattaccatt acggtgtgga aaaaattcaa 1899001 atgccgaaaa aaatcttcgg tgtgttcgaa cataccgttc tttcaaaaca cgaaagattg 1899061 gtaagaggtt ttgacgagct atactacgtg ccgcattccc ggcatacaga tataaatatg 1899121 gaacagcttc aagcagtgcc cgagttaaac attcttaccg catcaaagga agccggggtt 1899181 tgcttaattg tgtctaaaga cgaaaaacaa gtctttttga cagggcaccc tgaatatgat 1899241 acaaatacgc ttcttcaaga gtatgaaaga gatttggaac gaaacctttc tactgtcgag 1899301 gcccctaaac attattttgc aaaaggcagc aacgagccag tgaatcgctg gaaagcgcat 1899361 gccacattat tgtttatgaa ttggctgaat tattacgttt accaagaaac tccttatgaa 1899421 tgggactaat ttttcttttt ttagtgatac gctgagcaaa aaatatgata aaatacatct 1899481 gattcagtct gcgtataaca aaaatttaaa atactggaat ccaaatcatt taaaattagc 1899541 ttaacttttt cactgcatta ataattcgat tatgtatttg tgttatgttt atgtatagac 1899601 aataactcct tacgatgcat gaagcttgct tgttgttgat tacattgagg tgaatttact 1899661 tgaataccaa taaaagagta ttaattttga ctgcaaatta cggaaatgga catgtgcagg 1899721 tagccaaaac actttatgaa caatgtgtac ggctcggctt tcagcatgta acagtttcta 1899781 atttgtacca agagtcaaat ccgattgttt cagaggtaac tcaatacctt tatttaaaaa 1899841 gcttctcaat cgggaaacag ttttatcgtt tgttttatta cggagttgac aaaatctata 1899901 ataaacgtaa attcaatatt tactttaaaa tgggtaataa aagattgggc gaacttgtcg 1899961 atgaacatca gcccgatatt attattaata catttccgat gatcgtcgtg ccggaataca 1900021 gacgccgaac tggaagagtc attcctacct tcaacgttat gactgatttt tgtcttcata 1900081 aaatttgggt tcacgaaaac gtggataaat attatgtggc gacagattac gtgaaggaaa 1900141 aactgctgga gatcggcact catccaagca atgtaaaaat cacaggaatt ccaatcaggc 1900201 cgcaatttga agaatccatg cctgttggcc cgatatataa aaagtacaat ctttcaccaa 1900261 acaaaaaagt gcttctgatc atggcaggtg ctcacggtgt attaaagaac gtaaaagagc 1900321 tgtgcgaaaa ccttgtcaag gatgaccaag tgcaagtagt tgtcgtgtgc gggaaaaata 1900381 cggctttaaa agaatctttg agtgcgcttg aagcggaaaa tggtgacaaa ttaaaagttc 1900441 tgggctatgt ggagcgcatt gatgagctat ttcggatcac agattgcatg attaccaagc 1900501 ccggcggcat tactttgaca gaagccacag ccattggagt gcctgtcatt ctgtacaaac 1900561 ccgtgcctgg ccaggaaaaa gaaaatgcaa acttctttga agaccgcgga gctgccatcg 1900621 ttgtgaaccg tcatgaagag attctcgagt cagtcacttc ccttcttgca gatgaagata 1900681 ccttgcatcg catgaagaaa aacattaagg accttcattt agcaaactcc tctgaagtga 1900741 ttttagagga tatcctgaag gaatcagaaa tgatgaccgc caaacaaaaa gccaaagtgc 1900801 tatcgtaatg gcgtacttga gagcatacga aaatcgtgtg ctctttttat ttatattcag 1900861 ccatcaataa aagcggttac atttttttat ggaacttgcc cttcttttga aaaataagcc 1900921 gtttcgcaac ttgacgggtg ctcccagatg gtgtatagtt gaaccatcat ttaacaatga 1900981 atcaaagtta gatgatgaca aaattttttt tagcacatgg gtgctacagt actaggagga 1901041 attaagcaat atgcaaaacg gtaaagtaaa atggttcaac aacgaaaaag gattcggctt 1901101 cattgaagtt gaaggcggag acgatgtatt tgttcacttc acagctatcg aaggagatgg 1901161 atacaaatca ttagaagaag gacaagaagt ttcttttgaa attgtcgaag gtaatcgtgg 1901221 acctcaagct tctaatgttg taaaactcta aactcaatac atgatgatga gatgacaaat 1901281 agaggagagg cattcgcctc tcctatttga ttttcatctg gatttcaatc gccaaaatgt 1901341 tttgtttaca cctctgttca atctcttcaa catacttttc cattgatggt tttccttttt 1901401 tcgcgatatc ggccagttct tctaaatcac tgtatatttc tataaatgtt ttgtgaagga 1901461 tcaacttcaa gtctttatca tccatagctg cgttcccctt ctctatcaag atacctcaaa 1901521 tagtaaaacg gtcctattta ttctggttca atagttatat cggcttattt ttattttctt 1901581 ttctattttg gtacataaat ttcaaaaaaa ctctgcaaaa taatggcgga ggtgtttttt 1901641 gtgacttcag aatttcataa tgaggatcag accggcttta cggataagcg gcagctggaa 1901701 ctagcggtgg aaacagcgca gaaaacaaca ggagccgcga cgagaggcca aagcaaaaca 1901761 ttagtcgact ctgcatacca agccattgag gatgctagag aactgtcaca atctgaagag 1901821 ctggcagctc tcgatgatcc tgaatttgta aagcagcaac agcagctgct agatgacagc 1901881 gagcatcagc tggatgaatt caaagaataa aaaccgcagc ttctgcggtt tttattttta 1901941 gtgattggtt aagacatctc cgtattgttt caacttttca ccaaccgtac atttattgat 1902001 acaaaatgaa tgcgcataag ttttgccaaa ttctttgcga aactgcttct taataaaaca 1902061 gtccttgcaa tattcatcgt gcagttctgt cagttcttta aagatcattt tcttatccaa 1902121 tatcgtcatc tccgttacgg tctaatttcg tgtggctttc tacgaattga tgggatagaa 1902181 tttttttagc gaggccgtca gcttcctgat tgtcttttcg ttgtattgtt tcgtaggttg 1902241 gagtaagctt cagcgattca aggagtgctt ctattttgtc cagccattca ttatgagatg 1902301 gatcataaca aggccagctg ccgtcaagct gattcagcac aacaagcgag tcccctttga 1902361 ttgtaattga atttctgctt gccccaagct ctcttacttc tcttattgct tcataaagcg 1902421 ctgcgtattc agcttcatta ttggttttca gccggaagct tttatttttt ctcaagcgat 1902481 gccgggttcc tcccaatgaa taatagatga cgatcccgag accggccagt tcgctctctt 1902541 tatcgaaact gccgtcaaaa taaacagtaa tgtcatcagg ctcttgagca agctcctctg 1902601 tcagcttttc caattccttc agcgtccagc tgccgccttt ctcgtcttcg aactctagct 1902661 ccttcatgta tggaaaacgg ccaagttctc tggcgaacgt acgtgcctgc tgtgctgtca 1902721 gccagtcttc gctaaaaaat gagacggatc ccgttccttt tgcttctatt ttcaaatgcg 1902781 gtctgagctt cattacaatc accttaccat tcattagttg ccgggcttat gctataatca 1902841 aaccaatctt accccggaaa ggaagctttt tcatcttgtt taataattcg ttttggatct 1902901 tttttgcgat cattcatttt atcattgttc ttttatttta taaaggattt ggcaaaatgg 1902961 gactgtttgt ttggatcggt tttgcgacag tctgcgccaa cctccaagtc gtcaaaacag 1903021 tcgaactgtt tggcttaaca gcgacactcg ggaatgtgat gtatggcaca atcttttttg 1903081 cgacagatgt gctgaatgaa aaatacggac cagctgaagc cagaaaagcg gtatggctcg 1903141 gattctcaac gctcctgacg ctgacatttg tcatgcaggg cgtgctgctt ttcgaaccgg 1903201 cttccagcga catatcacaa acagcgctgg aaacgatctt cggattcctt ccgcgagttg 1903261 cgttaggaag tctgcttgcc tttatcttca gccaaacgct ggatgtttat gtatattcgg 1903321 caattagaag gatatttcct tctgatcggc ttttatggct cagaaacggc ggcagtacag 1903381 cagtcagcca gttgtttgat acattcatat tcactgcagt cgcctttctc ggcatttatc 1903441 cggcagacgt gtggcttcat atttttattt ctacatattt gattaagttt gcggtatctt 1903501 taatttcatt gccttatgcc tatgcagcca aaaaaatgat acctaatgat gaaaggagtt 1903561 cataatgcct acagaaatat atgtagacgg cgcaagcgcc ggtaatccag ggccttccgg 1903621 tatcggcatt tttatcaaac atgagggaaa agcagaatct ttctctattc caatcggagt 1903681 gcatacaaac caggaagcgg aatttcttgc attaattgaa gggatgaagc tatgtgcaac 1903741 gcgcgggtat caatcagttt cctttcgaac cgattcagat attgtggaac gcgccactga 1903801 gcttgaaatg gttaaaaata taacgtttca accgtttgta gaagagatca tccgattaaa 1903861 agcggcattc cctctttttt tcatcaaatg gataccgggc aagcaaaacc aaaaagccga 1903921 tcttctggca aaagaagcga ttcggctgaa tgaaaagaat taaatcttga tcattggttc 1903981 atcctaatgg cgaggtgaac taacatgaaa aagaaagata aaggccggct gaccggcggt 1904041 gttactccgc aaggcgacct ggaaggcaat acacataatg accctaaaac agagcttgag 1904101 gagagagcaa aaaaaagcaa tacaaaacgc tagagaggat ctaaacgatc tctctagcgt 1904161 tcagcttttc aagcatacgc tcaattcctt taatttggtg gcggcgaagc atgtcagccg 1904221 cctgctccat ttgcaaagta aataaagcgt ctttcagtgt gcaggccagc ggcactgagc 1904281 aatggatttc cgcaagcttc ctcgacatct ccaaatcgct taaaccttgc tgaatttttc 1904341 cctgctgtcc ttttggaaga agagaaagat tttccaataa acggtcaatc gtttcgtatt 1904401 cacgaatcag tttgtaggct gttttttctc caatgccttt gactccggga tagttatcac 1904461 tggaatcacc cataagcgct ttaatatcaa tcaaagcctt cggcattacg cctgtttctt 1904521 cataaaaagt ctcttttgta tagactttat aatttccgat tcctttttga agcaaagcaa 1904581 cgcttacttt atccgttaac agctgaagta aatctctgtc ccctgttacc accgtaatgt 1904641 ccgcttcatt cgcaaataaa tcggcaagag taccgataca gtcatccgct tcatagccgg 1904701 caaagccaat attcatgatt ccaagctctg cggctgcttc ctttgccaaa tcaaactgcg 1904761 gaatcagctc cacaggcggc gcgctgcggt tggccttata atcttggaac aagtcatttc 1904821 ggtacgtttt gctccccatg tcccagcagc agacgacgtg tgtcggctgg aatgtttcca 1904881 cagctgtaat caaatgcttt aaaaagccgt tgacgccgtt cgtcggcacc ccgctgtcat 1904941 ttatcataaa gttgcgatgt acggccgtgg caaaaaaggc ccggaataaa agagccatgc 1905001 cgtcaaccag caatagttta ttattattca tcaaataact cccttttctt tcattccttc 1905061 tattttatca taaagcagcc caaaaataaa aaacagtatc tctttaatta gagatactgt 1905121 ttgaatattt atcaatcgtt gtgtcttttg ttgctggcga tcagcttttc agcttcgcgt 1905181 cctgcgtaag agtcaaaatg ggtttgaaat ccgtttttct ttttggcgtt gttattcgcc 1905241 tgtgcatttc tgtttccgag ctttgttctg cccaacatga atcccccctt acgtcggatg 1905301 catatagtat atgcttccgg caggaggttc actcgcgaca ggatcatcca gcttacatgc 1905361 ggcttacgta ttctctgacc atttcttttg atacaagccg tcttgtcggg acgatgcctt 1905421 ttttagcgag ctgattcatt tgctcggtaa tttcattaat tgcatctgta gtataaggct 1905481 catcgtttct gcatttagca acagcttctt caatcgccaa ttcacgcata ttttcaagac 1905541 gcataaatgc tttgatatgc tcgtgctgtt ttgatgaatg tgctgaaatt gctttatgta 1905601 cctctgacat taatcgttca tctcgctttt ttctatttag tctatcatga cttgaaatac 1905661 aagccaactg aattttacat ttttattgta ttgtctgaat ttttccagga gatgcacgcc 1905721 tgatacgcca tttcaatctc tttcgcatgt tccccttccg catatcctct taaatatgtc 1905781 tctttttgat ccgttatttg cgcgattgct ttttcaccca tatcttcctg taagcgtctg 1905841 aggtgagcag tgtaatgaga tatcaggctt tcttcttcat tttttatcca tgcctctgtg 1905901 attttcgtaa gtttcatccg tacagcttcg ataaaggtcg cttttccttt ctgctcaaaa 1905961 aactgcttcg gtgatttgat ctcttttagt tcctgctcaa aagcacgttc ttctatttcc 1906021 ggttcaactt ccttcaactg tatgccgttc gaatgctgat cacccgcata aacggaaaaa 1906081 taaccgtcct cgtttaatgt tttttgaaaa tgatccagcc attcttcatt gatatgccgt 1906141 tcgatgaaac cgctcatgcg aacatcaagc gttttgattt cctgaatata ttcaaataga 1906201 tattcatgta aggctgttgt catcgcttta ctgacgttct ttttccaatc cccgttttgc 1906261 agcccgggat gaaatgccga ttttaataaa tcatttgcaa aatatgataa tcgctgtgca 1906321 atgtgatata gctgctctct tgtatctttt tttacttttt caatgatggt ttttgagttc 1906381 cgccgtttct cgatatcggc cgctgtccgc tcaaatgaca gcataaggca ctgtttctgc 1906441 gcttccttct cttctcggga ctgatgctgg gattggtgaa gctgaaaaac agtttcgcat 1906501 agtttgtctg cctccgaact gagctgcgct gctgacgctt tttttacatc cacttcgata 1906561 aaccggtcta agtgttttct tactttcgag aactgattat aaaatgactc cggttttccc 1906621 accagttcct ccttacttga tacggtaaag agctgcggct cataaacccc ttcttttaca 1906681 agctctgcgc tgacataatc ggtcactgtt tcgagctctg ttttatcttt tgcaaggtct 1906741 gcagcattaa taataaaaaa cattttatcc atgctgagcg attctttcac aagtccaagc 1906801 tttcgcaaaa atgaacggtc tccttttgaa aaagagtgct gataataagt catataaaaa 1906861 aatgcatcag catctttgat atattggaat gccagttctg tatgccgttt attcatgctg 1906921 ctcgcgccgg gtgtatcaac gatcgtaatc cctttttcag tgagcgggca tgtatagtag 1906981 accgttacct ctttcacagc acaggccgtt gtttcctctg ctacatacgg ctttaattca 1907041 gagagcggaa tcgttaattt cttctgttcc tgtatatact gctgatactt ctcgtatgca 1907101 agcaggaaat tgctgatcaa tttcacgtgt tcttcctgca gcctgttttt tttgactgcc 1907161 ttttcccact tctctgtgaa ggaacggcct gccggctcct ttggtattcc ggtgagctgc 1907221 aaaatttcag ccgttaagtc atcctctgtc ttaaacacta cattcgctgt tttgtttaag 1907281 ttgccattga ttggctttgt gatcttgtta attgtcgctg tggttggcgt tggtgaggat 1907341 ggcagcactc tttcgccgac aagcgcattg gcaaatgatg atttccccga gctaaagcct 1907401 ccaaaaagag cgagtgtaaa tttccgttcc tcaagccttt tcaccctttc acgaaacgct 1907461 gaagtttgct ttaacaacat gctgcattcg cctaaaatgt cagacaaagt gtaaaagcgt 1907521 ttgatttggt cttgaagcgg catttcttgt tccattttga tttctgattt cggcatcggc 1907581 tgcgccgtca gctggcttcg gccttgtttc tgctctggag ccgccactct tgttttcttc 1907641 gatttaaacc attctgtgtc tatatgcatt gggcatgcgg actcttcttc ccaaatggcc 1907701 cacaggcgat cggttttctc tcgggcatta ttctctaaac gtgcctgttc ttgaagaaag 1907761 acaagttttt ctgattcttg gacgagccgg tcgttaattg tttgcacatc tttggaaaca 1907821 cgctctttca ccatagcgga gagcaccttt atgatgtctg cggcttctct tttcgcctct 1907881 ttccggatga gctctgccaa gtcttttgta tattgcaata catattcaga ggaaaaggct 1907941 gcaccatgct tgaccgcgtg ttcaatgatg cttatatcaa gcggtgtgcg ataggcctga 1908001 atcagctttt cactttcagc ggtatagaca tcaaatacct tggcgagttt atgaagcgtg 1908061 tctatcatat gccaatccgc ttcggcctct gttcgttttg ccacatcaga gaaaaaagca 1908121 ttccgccttt tatctctttc ctgtgcagtt ttcgctttag aaaagaaaaa gccggtttta 1908181 aaggaaggct cttgtgattc taaaaatgca gccgccaatt cacgcatttc aaaaggcgtc 1908241 aggttggcgt tttttaaaat acgattgatt tcttcctgca tcctcttctc tgcctcagtc 1908301 atttgttttt cggcctcatc caattgatca cgcagcgatt ggaccagtcc agtatggata 1908361 ttaagctgtt cagcgaaact cggagcgcct gtttcgtctt tcttcagcat ttccgtatgt 1908421 tcctttagca gattacggac tttttgttcg gttaaagcct gcatattgct ttttgattgc 1908481 tgttctattc tgcttaactc ttctctcagg gcccccatct gattgaacgg gtgatccggt 1908541 tctgttactg atgtaaaata gagcgcttcc cttgaaatcc cttcattgca aagcatctcc 1908601 tctacctgcg cttgatagtc tccaaatttc gtctccgtct catcatggcg gtcaatttga 1908661 ttgacgataa aatacacatt cggaatgctt tcttttattg atctgagaaa ctttacattt 1908721 tcctcagcgt gcacgtgatt atagtgaacg acgtaaaaca gcgcatccgc ttggtgaaga 1908781 atagaagcag ccgatagaaa atgcgcatca tctgttgaat ctatccctgg agtatcaata 1908841 tacgcaaccc cggaatcgat ctcagtatac ctgtcaaaaa tttcgacgct ttcaatctgt 1908901 tccccgtctt tacaatattg ctgcaccttg tctttctggt aagtcccttc cagctcagca 1908961 cacgctccgt ctgttgtatg aagccgaact cgcttttccc cgtttctgat cacaacaagg 1909021 ttagcgcttg tcggaatcgg gcttgtcggc aaaatattct ccattaacag gcagttcagc 1909081 agtgacgatt tccccgctga ataatgcccg gtaaacgcga tataaacctc ttcatcagcc 1909141 gcttttttca tgaccgcagc cagtttagca gccctttgtt catcttgatt ctcaataaat 1909201 tgcttataaa gttccccggt tttatgcaaa agctcttttc tgttttgatc tgtcataagt 1909261 ctgaacccct ttgtgccgtt tcaattgtga acctttttcg aaagatctga attcattccc 1909321 ttttcatttt acacaagaat aaaccaaatt tctttaggag aatagaaaaa agccgccatt 1909381 acggcagctt ctataaaaga aaatctgcaa cttttacaag ttccagattc atcaaacaga 1909441 tttattagag attcctttta atacaaaacc aattaataca ctatatgtac aaaccgctcc 1909501 aagcaaaaac agcattgtca tttgcttcac catcctgatt gagaatcttt ttcaaaccca 1909561 ttttaacatg gttgagaatg attttcaatc gctattttac gctgtattcc tgtaatgctt 1909621 tgtcttctgc gcgaattctg acgcttaaca acacggcatt gaaaatggaa aacagacaca 1909681 tggtgacgta tgcttgataa agcagcggaa tcagcaaaat ttcgaggata acaacggcat 1909741 agtttggatg tttcatccat ttatatggac ctttttttac aagctctaca cctggaacaa 1909801 caaggatttt cgtattccaa tatgctccta aggaacaaag cgcccaatac cgtacgatct 1909861 gtacgcttaa aatcactgca gcgataccga gccaccagct ggacggctgt ttattcatca 1909921 gcagcacctc ggcaattaag gacaggaaaa aaaggatatg catcgtaatg atatacggat 1909981 agtggctctc gccaaattca attgctcctt gcttctttac cttttgttcg ttttgcctgg 1910041 ccactgccat ttctgctgct ctttgaacaa tgagaatggc gatcaacaac caaaacatga 1910101 gtcaggcccc cttttcccag ctgaataata gcaactctga tgagaaaccc ggccctaatg 1910161 cgccaatcag tcctcgttca gcttcctttt tatgtccgtt ctgcagatgg tctttgatca 1910221 catacaagat tgtggctgaa gacatatttc cgtgcttttg caaaatgctt tgcgcagatg 1910281 aaagcttttc tgacgacagc ccgagacttt tgatgtatgc atcgatcact ttttttccgc 1910341 ctggatgcgc caaaaaaaca ctgatatcat ggaatgacag cttatgtttg tccaaaaaaa 1910401 tctgtacatt tgttttgagc catttttcca ccaaggtcgg aatgtctcgt gagaaaatga 1910461 ctttgaatcc ttgatcggta aagtcccagc ccatgacatc ttctgattgt ttcatcaaaa 1910521 cagattgggc gtccattatc ttcggcgcaa gcttcagctt tgacaccctg cggtccgcct 1910581 tctctccgca taataaagct gcggcaatgc cgtcaccaaa aagcgaggtg ccgatcagat 1910641 tgctttttgt tttatcttcc ggctggaatg tcaggctgca cagctcggca gaaatgacaa 1910701 gcacaaaagc ctcaggatac gctttgcagt attcggctgc acgcgcaagt ccgctggctc 1910761 ctcctgcaca gccaagcccc caaatcggaa tccgcttcgt atatggagaa aacggaagtt 1910821 cattcataag ccgcgcctcg atactcggtg tggaaagacc tgtactggag acgaaaaaaa 1910881 cagcttccac tttctcataa ggaatggctt cttgaaaaaa ttccggatga gagaggcact 1910941 cacgaacagc cgctctgctg tgtttaagtg tttcttctat gtatatttga tttttttctt 1911001 caaagctgtg cccctcttta taccattcaa tcggcttaac aaactgtctc gaatggattt 1911061 gcccgttttt aaaggaggat aacagcctgt caatatcctt aaaagaatgc tgaaacatat 1911121 agcgggcgaa ctcggccgct ttctcttggt ttacattata cgcaggaaga cttgttccaa 1911181 tggataaaat aaacgccatg cgatcacctc tttgcataca ttgtgccgca acaatctttt 1911241 ttatatgcaa aaaaaactcc gccgcggcgg agttagactg ctgttttttg ttcagcgagg 1911301 tcagcttctt gttctatttt tttagcttta gaaaaaacgt tatatacaat atttaagacg 1911361 actgcagtaa agctgcccgc cacaatgcca ttcgttgtaa gcagcgttaa ggcactcgga 1911421 agctgtttga aaatatccgg cacaacggtc acaccgagcc ccaatcccac tgagcaagca 1911481 acaatcagca gattttcctg tttcgcaaaa tcaatgcggc tgagcatttt aattccgtaa 1911541 gcaatcacca ttccaaacat cgccaccatt gcaccgccca aaacagcgga tggaataata 1911601 gtcgtgaaag cagcgatctt tggaaacagc ccaaatgcca ttaggatcac acctgtgacc 1911661 acaatgacgg catttttttt gatccctgtg agctgaacaa gcccgacatt ttgagagaat 1911721 gccgtgtaag gaaaagcgtt aaaaataccg cccagaagca cagccagtcc ttcagctcga 1911781 tagcctttag acaaatctat ctctgtcaaa cggcggtttg tcaggtcacc taaagcaaag 1911841 taaacaccag ttgactccac aaggctgaca attgcaacga tggacatcgt aatgataggc 1911901 gctgcgtgaa aagacggcgc tccgaagtaa aatggctgaa tcatttgaac aactgccgcg 1911961 tccgaaacat tatcaaattg aacttttccc ataaaatatg cgatgaaggt gccaatcaaa 1912021 ataccgatca aaatcgagac ggacttgata aagccttttg taaaacggta tagaagcaca 1912081 atgatactca acacggtaaa agcaagtgca agattggaga gatctccgaa atctgcactt 1912141 ccttctccgc cggccatgtt attcatggca accggcatca gtgtaatacc gataatcgta 1912201 acaacagagc ctgtcacgac cggcggaaaa aacgatacga gctttccaaa gaaaaatgaa 1912261 ataagaatga caagaatgcc tgaagcgata atgctgccgt aaactgttga aaccccatat 1912321 tcagatccaa tcgctatcat cggcgataca gctgtaaagg tacagccaag cactaccgga 1912381 agcccgatcc caaaaaatcg gttgctccac acttgcagaa gtgtagccac accgcacata 1912441 aaaatatcaa tcgatactaa gtaagtcagc tgctcgacag tcagtcccat tgcttttccg 1912501 acaatcagag gaacgacaat ggcgccggca tacatggcaa gaacatgctg aatccctaaa 1912561 gacagcgttt tgccgaatcc atttctcatg aatgaacctc ctgtacgaag gacacttttc 1912621 cttcttctaa agactgaatt cttgccaaag attccactcg gtagcccagt tttacaagtt 1912681 catctcttcc cggctgaaat gacttttcaa taacaatgcc gattcccgca atagaagctc 1912741 ccgcttgctt cacaatcgac acaagcccgt gcgctgcctg tccatttgcc aaaaaatcat 1912801 cgataatcag cacatgatcc tgatccgaca ggtgggtccc agacactgcg atttggcttt 1912861 ctgtttgctt cgtaaaggaa taaacagacg ctgtcagcaa gttgtcggtg agtgttaacg 1912921 atttatgctt tctcgcgaag acaactggca cacccagctt caagcccgtc attacagcgg 1912981 gagcgatacc tgatgattcg attgtcacaa ttttggtaat accgtctttt gcaaacctag 1913041 acgcaaattc atcaccaatt ctctgcataa gcagcggatc aatttggtga ttcaaaaaag 1913101 aatccacttt caatacctga tcagataata cgacgccttc ttcctctatt ttccgtttca 1913161 gtgcttccat cctgtctacc tccgttatga gaataaaaaa agcattgccc gctcaaataa 1913221 agagcaagca atgctgatat cacaaaaaac cgtacacgtg cggttccatt gctcacccat 1913281 agtcggacat ttacggtgcc cggtagaaac ttgcgtgcca tatccacgcg attatatgag 1913341 tgttcctatt atattgtaat aaattatatc aagattctaa tctcttgcat aggctgaaaa 1913401 taaaaattcc cgaactttaa ttttgttttt ttagatatca ttcgtatttc aaggggattc 1913461 gatataaaag agtctgacga ccgcgccgcc aggcttttga ttataacaga tagagatttg 1913521 aatatttgtt tgataaataa tcaattaaat agcgaacatt cagctcttct cctgttgcat 1913581 ctttaataat gtctaacggc tttttccgtt ttccgtgaat gtgcaccttt tccgtcagcc 1913641 attgctttat cggatggaac tctcctcttt ccaagagagc gtcaaattca gggagatcct 1913701 caagcatttt ttgtttcagc tgagccgcat acatgtagcc gagcgcatag gatgggaagt 1913761 agccgaaatc tccacctgcc caatggacgt cctgtaaaat cccctctgcg tcggtctgcg 1913821 gtgtaatccc taaataatcc tggtattttt gattccaaag cgacggcaga tcttccacag 1913881 acacttcatt gctgaaaatc gctttttcaa tttcataacg gatgatgata tgaagaggat 1913941 acgtcaattc atccgcttcg accctgataa atgaaggttt tgattcattg attgcccgga 1914001 caaaatcatc cagggagatg tccttgaact gtacaggtga tgcctcttga atcttcttat 1914061 agtacggagt ccaaaaatgc ttgttgcggc cgataaaatt ctcgtaaaat aatgattgcg 1914121 attcatgaat tcccatcgat gcgccgtctg acaagttcgt gccactgagt gcttcatcaa 1914181 tattttgctc gtaaatcgcg tgcccgcact catgaatggt cccaaagatc gccgtccgga 1914241 aatctttttc atcatatctc gtcgtgaccc gaacgtctcc ccgattcagc gtagttgcaa 1914301 acggatgaac ggtttcatca agtcttccgc catcaaaatc gtagccaagc tcctgtaaaa 1914361 aatacagact gagctctttt tgcttttctt tcgggaacgc ttttgtaata aagcttgtat 1914421 ctggtttatt tccggaagct gtcacctgtt taacaagagg gataatcgct tccttcagct 1914481 cagcaaacaa ctgatcaagc acctttaccg tgacgccggg ctcaaacaaa tcaagcaatg 1914541 catcataagg atgctcttga tatccccaat acgtaataaa acgtttattg aattcaatca 1914601 gctgttctaa ataaggagaa aacaagctga aatcagattt tcctttcgct tcctcccacg 1914661 ctgtttctgc ctttgaacac agaatcacgt attctttgta ttcagcctca gggattttct 1914721 tattctcttc atactctttt ttcgccagtt ccactgcttt tttcgtatct tccgacaagt 1914781 catcaaatcg ttcatacagg acatcgataa gctccttcat tcgatctgat gtttggatat 1914841 tgaatatatc tgttgaaagc tggccgatac tttcggcacg atcctctgag ccatttttcg 1914901 gcgcgcctgt tctggagtcc cagtgcatta acgcaactgc ttcgctgtaa tgtgagattc 1914961 tttttaaaag atcaaaaaat tctttttcat atgtatgtat ctccatatcc attccctccc 1915021 tattctagcc gttccattac aggctaatgg aagggggtat gaaagtcaaa ttgtttgtat 1915081 aaaaggctgc cggtatgttt tgtggcagcc tttttattca gttgatcgtc atttgatttt 1915141 ttggcggagg tgttctccgc tttttctgct tgattttttt atctacccac actgttgcca 1915201 gcggggttaa gagcgaggtg acaataacgc ttgtcgcgat aattgcagtt gccgactcag 1915261 caactggcgc aaatgaggca ttcgcttccg ctaatgcata tggcacggct acagccgccc 1915321 ctgccgtaga agaagcggcc actcccgcga caccatctcc ccgcgcaata aaacgatcaa 1915381 gcaaaaacaa agaactgccc gataaaatga cgacagaaac tccgataaaa atgccgagca 1915441 gccctgattg gatcagcatt ccaaaattca aggtattgcc gagcgaaaag gcgaaaaatg 1915501 gaatgatcgc cggcacaacc ttgctgaata agtctctgag atcatgatcc agatttccaa 1915561 gtatacatcc aagtaaaaac gggatgactg tcgctgccag cgtttcccat gggaatgcgg 1915621 caagtcccgt cacaccaaac gtcaccatgg tcataaaagg accagattct gtactgataa 1915681 aggcgaaagc gcccgcatcc tcttttcttc ccatgtgatt catgagcgcc aaatacagtc 1915741 cgccgttcgt ttcattcatt accgcgacaa ttgctaaaac agaaaggcct gcaaaaaagc 1915801 cggattgtat gccatcgtca ggtataaatt gcgctgcgat cacgccgagc agcgccgcaa 1915861 atccgatctt ccccaataat aacgtgattc cttttcttgc gatatagcct gaagaacgaa 1915921 aatcaatcgt tgctcctacg caaaagataa aaacacccag tatcggcagc gttccggtaa 1915981 tcaaagcacc cgtaaaccct ccaaagaact ccgctgttcc aggcgcaaac gtgttgagcg 1916041 ccgctccaag aaatagcgga ataatcatca ttccgccagg tacccgttca attgtcgcct 1916101 tgattttcat attgtggatt ctcccatcct ccggttatga aaaaacaatt ccacttacac 1916161 ttggaaaaca gcctgcaaat cctcttttga acagctgccc aactggctgc cgactccgac 1916221 ggcgccagct ccggctctaa gccaatcagg cacttcagac ggatgtatcc cgcctgtcgg 1916281 aataaaggtc acctgcggga aaggacccgc taaatttttc ataaacggaa tgccaaacac 1916341 accgcttggg aacagcttta atgtcgtaaa accgaatgtc agcgcttcca taatttcgct 1916401 cggagtcaag acgccgggga tataatgtgt ctttacaaaa gatagatgtt cagcaagatc 1916461 agctgaaaaa cccggactga caataaactg cgcgccagcc ttagcagctt ccccagcttg 1916521 ctgcgcgctg atgaccgtac ccgcgccaat taaaatatct tccctattac ggaaggattc 1916581 gataatatct gatgccccgg gggtcgtata cgtcacttca actgcacgaa tccctttatc 1916641 taataaactc tcaatctgct gacaggcctc ctgcttatcc tttgaacgaa tgactgcaat 1916701 cagctttgct tctttcagac ggttttcaac gactttggac tccatattaa taatcccctt 1916761 tcttttggtg aaccgttctt tgagcagata aaaaagaagc taatttctcc ctggtcggca 1916821 aaccgtccat atcccccggt gcctgcactt gcaaagcgcc aatcgcattt cccctttgca 1916881 ccgcatcctt gtacgacaaa ccgtctagga taccgctgat tacaccgact gcaaatccgt 1916941 ctccggcgcc gaccgtatca accacccggt cgacccggca gccttctaga aatccttcac 1917001 ttgtccccgt tttaaagtaa gcgccttctt ttccaagttt aatagcaaca aagctggcac 1917061 cttttttcaa ataatagtcg gcaatgcctt caggtgtttt ttctccggtc aatagctctc 1917121 cctctgcgat acccgggaaa aaccagtctg caagcccagc cagatcattg attgtgtgta 1917181 ccattgttgc ttgatcaggc caaagcgaag gtcttacatt agggtcgaat gaaatggtct 1917241 tccctgcgtt tctcatgtcg ttcatgacat gatacgtgaa gtctttcatc tcggctgata 1917301 aagcaggcgg aatacctgtc acatgcaaat ggcctgcgca ttgaaaataa tctctcggat 1917361 attcagctgt agttaatgtg cttgcagctg agtttttcct atagtaggta acttgcgggt 1917421 cgccttcttt cacttttgac ttcagcagca gcccggtggg attttcgtcc tgcgagcgga 1917481 tcacgcggga cacatccact ccctcttttt taagctcttg taaaataaac gttccgagct 1917541 gatcattgcc gaccttgctc atccatccca ttcgaaatcc gagtctggca aggccgcagg 1917601 cgacattgct ttctgctccg gcaagccctt tagaaaaagt ggatacttca tgaaggcctc 1917661 catactcatt tgcataaaac atggccattg attccccgaa tgtcaccgca tcaagcttca 1917721 tctcttccca acctcctctt agttgagggc acctaggatt aaagtgactt tctcatgatg 1917781 acttttgcct ctaattcaat ggtttgaggc gctcctttgt caccttcaat cctttttaat 1917841 acacgttcca tcgccgtcct gcccatatca tgtgacggct gggcgatcgt tgtaatgcct 1917901 ggaccgatca gtttgtacca ctccgtatca tcgaatcctg caatccctat atcttgaggg 1917961 atgcgcaggc caagctcttc catacagctg atgattttca gcataatcaa gccattcaaa 1918021 gccagaatcg cttttttttg ctccggcatt tccttgtgaa aagaacgaag ctccgcctta 1918081 agctgctcct tgtcctttac gtcaatttca tgcaatctga caagcccgtt cacattttga 1918141 accgaagcca tttcctgata cacagctgct ctttctgcac gagggctgat agaggaaatc 1918201 ggttcggtaa acagcgcgac atcagtatac cctttgctgt acaccttctg aagaatctct 1918261 tttgtgatcc atctgttgtc agtcgttacg gtatccagtt tcagatccgg cagtttccgg 1918321 tcaattaaga ttgttggaat ttgctgttca gcaaaagcgc ggagtacatc cttgttttcc 1918381 cctgttgcgt ttaaaatcaa gccctcaacc gaatgggctt ctagctttaa gagcatttcc 1918441 cgctcttttt caggactgtt atctgtgttg cacaccataa tgctgtatcc atattgatca 1918501 caaacctctt cgactcccct gaaagcagcg accgaaaaag gatttgtaat gtcagccaca 1918561 acaaatccga ttaacttgct tttttttatt ttcaaacctt gtgccatttt actcggccga 1918621 taattcaatt ctgcgattgc ctttttaatg tttttcactt tttcaggaga aatcgcgtca 1918681 atttttccgt taatatagcg ggaaactgtc gatttcgaaa ctcctgcaca ttcagctacg 1918741 tctttgatgg ttgtatggcc tgttgttttc tttttcattc aagtgctcct gtatctcata 1918801 tatttgaaac cgatttcaaa accgttacaa caaaagaata ccataatttt aaaatttggg 1918861 aagagttttt ttaataatat gtcaattcat tattttttcg ttgactcttt tcactattta 1918921 tcctaaaatt ttctttgaaa ccgttaccaa aatattttca ttcaagtgat gctgaaatcc 1918981 taaccaaggg ggaaatataa tggaaaatcg ttattctgta catcctgaac aagtaaaacg 1919041 ctttacaaca gaggagcttc gcagtcattt cttaatggat tctttattta cagaaaacaa 1919101 acttacgatg tattactcac atgaagaccg ggttgtcatc ggcggagcgg ctccagggca 1919161 aagtgaactg aagcttgatg caggtgattt tctaaaaaca gacttctttt tggaacggcg 1919221 tgaaatcggg attattaatg tcggccagcc tggtgccgtt agagtcggcg atgatgaata 1919281 tgtgcttcaa acaaaggatt ttctctatat tggaatgggc aatcaggatg tatcgttttc 1919341 aagcctgaac ggggaaaaag cgaagtttta cttcgtctcc gcttgcgccc acaaaagcta 1919401 tccgacacaa aaagccgccc tatctgaact gacaccggac cgccttggtg atgatgcagc 1919461 gtctaatgtc agaagtctgt acaaagtcat tcatcaggat ggcattaaaa gctgtcagct 1919521 gatgatggga ataacgatgt tagatcaaaa caacaactgg aataccatgc cagcacacgt 1919581 tcatgaccgt cggatggagg cttatcttta tctggatctt gaaaaggact caaaggtatt 1919641 tcatttcatg ggccagccgg acgaaacacg ccatcttgtt gttggaaatg agcaggctgt 1919701 cctttctccc gcttggtcta ttcattctgg cgcaggaaca tcaaactata gctttgtgtg 1919761 ggcgatggct ggagaaaatt acacatttac ggacatggat ctcattccaa tggatgggct 1919821 gaaataagat gggttatcta catgacgcct tttcattaaa aggaaaaaca gcgctggtga 1919881 caggcccggg aacagggatc ggtcaaggaa tagccaaagc cctagccggg gctggcgctg 1919941 atattatcgg cacatcacat acaagcagtc tgtctgaaac acagcagctt gtggaacagg 1920001 aaggccggat atttacatct tttacattgg acatgagcaa gccggaagcg ataaaggatt 1920061 ctgcagctga gctgtttgaa aacaggcaga tcgacatcct tgtcaataat gccggcatta 1920121 ttcatcggga aaaagcggaa gattttccag aagagaactg gcagcacgta ctgaatgtca 1920181 atctaaacag cctgtttatt ctgacacagc ttgctggcag gcacatgctg aaaagaggtc 1920241 atggaaagat tattaatatt gcctctctcc tgtcttttca aggcggcatc ctcgttccgg 1920301 cttacaccgc gagcaaacac gctgttgccg gtttgacaaa atcatttgca aatgagtggg 1920361 cagcgtcagg tattcaggtc aacgcaatcg ccccaggcta tatttctact gcgaatacaa 1920421 agcctattcg ggatgacgaa aagcgaaatg aggacatttt aaagagaatt cctgccggcc 1920481 gctggggcca agcggatgat atcgggggga ctgcagtctt tttggcatca cgtgcttcag 1920541 attatgtaaa tggacatatt ttagcagttg atggcggctg gctatcccgc tgacaaataa 1920601 aaaagctgac gaacgatcgt cagctttttt ccattacatc atgtgcggtt caacaggcaa 1920661 gacctttttg acctcatcaa tgatgcgttc attttctccg ccagcgtaaa tgtgaatcga 1920721 gccgctgtct tgattcgagc gaatcaggcg cccgatgccc tgccgtacac gtaacaacat 1920781 atatggcaga tcaacttctt cgaacggatc ttttttcgct ccgttgcgct tcgctgtaaa 1920841 tacaggatcg tgtggcggga acggtaatga ccaaatggta acattcttca atgcgtcacc 1920901 gggaatgtcg agtccttccc ataagtgaac tgaacaaagt actgtttctt cttcctcttg 1920961 gaatttctct actaagctgc tgatttcctc atcaccttcg aagaaaattg gatacggcag 1921021 ctcccatgcc gccgacagct ctttaaactc gtttaattct tcaaaagaag ggaaaagcac 1921081 cagcgttctt cctttgtatc gtttgattgt ttcaatcgtt tcagccgttt tttgttcagc 1921141 gtccatatct gtttttgcgt atagattaat actcatttgc tcgtcataat cataagggga 1921201 atcaacagtt aatgacaaat aatcatgaat cccaagactg tcggcaatat aatcaaacga 1921261 accgccttct gacagcgtag cagaagaaaa gatataagga attttcttag aaaacacttt 1921321 ttcgccaagt acttctgcta ccgttctcgg catcacgaca aaggttgatt ctgcttcctt 1921381 tttctccagc cagctgatcg catccttttg atatagagat aatgaatacg ccatttgttc 1921441 aacatattct tccactactg acagttcgta ttgatcaatc gtatacattt cagactcaaa 1921501 tacaagtgcc tcaccgattt tatcaagtaa acggcaaagc tcgtccgccg cctttttgac 1921561 acgatggtca ttttttattt ctaaacggtg tgaaccggct acttcctttg attcttcaga 1921621 aagaacatag aaaaattcgt cgtttgcgag aagcgcatct tcaatcaatt ctgcaaactc 1921681 ttctctgatg tcattttgca gcaatcgttc taaaaacaat tcaagagtag actgcttcac 1921741 tctataggtt agcgcttttt gcgcagcaaa ctctaacaag tgcccctcat caaatacaac 1921801 tgcactatga tcaggcaaga gcggcagctg gccctctcgt ttgcgtgatt cttccgtcca 1921861 cacatgctcc atataaaaat catgggaaca aatgattaag tccgttgact tgcggtagta 1921921 atctctggaa agtgtcagac cgcatctgtg tctcatatca caagtcagac agtcctgaaa 1921981 cgagtcgtag cttacgtcag accactcttc attcgataga tttgcgtact gcttacggtc 1922041 gccatacgga taaaagcgct gcatcgcctg ggactcgtgg acaaatgacg gtaacgactc 1922101 ataaagatcc agccatttat catcatcaga acgctgcatt gttttttcaa gcttcttcaa 1922161 gcataaatat tgctcatgtg attttgacag ccttgtatca attttcagat caagatgctc 1922221 agccagctta gaaatatcgc cctctttttt caccagctgt tcaattaatg tttcatccgc 1922281 acaagcgatg atggcaggtt tgccgacata ccttgcatag ctgattgcaa aaagaagata 1922341 taccagcgtt ttccccgttc ccactccagc ttcggcgaac atgacttttt tctctttaaa 1922401 cgcccgctcc agctgaaaag ccataaatac ttgctcgtcc cgaagatcaa accctttttc 1922461 gggaaggata tcgtaaaaca cgtcaccaat ccaattgttc aattcttcat aaaaattctt 1922521 tgttttcgtt aaagaaaaag gcaaacgtga tgttgtcacc tagttccaac ccccaactat 1922581 tcgacattca gaccaccaat aatatcattt tccgctgatg aatacaataa aaaacttggc 1922641 aatgccaagt tttttgcagt ttacttacga ttgatcacat gcgacgataa aaaaggatgg 1922701 tctgttgaat aaatatgttc taccgctttt tctaaatcag tttgcgcatg cgaaatcaca 1922761 gacggagacg aatcagtccc gagctccttc agctcgtttg ctgttgcgtc aagcgccctt 1922821 tgaataagat taaaatgttc gctgttcagc atgagatcac ctctgatgga aataatcatc 1922881 attgtatgcg aacttttcat tttatataca tgctttaccg catgttatca ccgaaacatg 1922941 cacaaactac acttgatatt ccgtctccgg attatccgtc ttatcaacaa tattctatca 1923001 gggagtgatg ttgacatgag ttatagaaac cgattagatc agcattctga actgtttcat 1923061 cacaattgga cgcggcctaa acgttcaaag tctcaagtaa acggtcacac tgaaatgtcc 1923121 caaaccaaca ttatattgag aagcaacgcg aaagctcacc gttggtaacg atagaatagg 1923181 gctgaaagat gaaagaagac gcatgcagag cgtcttcttt ttatgcgttt tctgttttct 1923241 tgcgctgcgg tcttactttt gaccagtatt gataataatc cgttttaata aacccgttaa 1923301 agagttttcg tttcttcgtt gcttttctgc catatgcttc ctcaaagttt tcatttgatg 1923361 tcagcatata cacagaccaa gtatcaagcg gctcgaacgc ctgccccatt tctttgtaca 1923421 tctgctcaac ggcttttttc tcgccgagac gctctccata tggcgggttg ccgacaatta 1923481 cgccaaattc cagatttgtg gtaaagtctt tgacctgcat ctgtttgaac tggattagat 1923541 ctcccaatcc tgcttcctct gcattttctt ttgcgatttg aaccatgcgg tggtctatgt 1923601 cgctagcgaa aattgtaagc ggctgatcat aatttgcctt ttcttcgact tcaagccgcg 1923661 ctttgttcca cagatcttta ccgatccatt cccaatcctc tgatacaaaa tcgcggttga 1923721 atcccggggc gatgttttgg ccgattagcg ccgcttctat cgcgattgtt ccggagccgc 1923781 agaaaggatc aacaaacggg cggtcaggcg tccaattggt taattgcacc aaagcggcag 1923841 caagtgtttc tttaatcggc gcaccgccct gatcgacacg gtatcctcgt ttgtgaaggc 1923901 ccgtccctga tgagtccagt gtaatcaaag cctgatcttt caataaagat atttccactt 1923961 tatactcagc acctgtttct tcaatccaat cattggcttt gccggactgc agcttgagct 1924021 tttcgacaat tgcttttttg acgatccgct gacagtcagg aacgcttgca agtgttgatt 1924081 ttaccgattt tccgatgaca gggaatttcc cgttttcagg tataaatgag cgccagttaa 1924141 tcgctttcgt tttttcaaac agttcatcaa atgttttcgc tttaaaagaa gcaacctgaa 1924201 cctttatgcg gtcggctgtt ctaagccaaa ggttcgcacg gcagatggca agtgcatcac 1924261 cttcaaaaat aactttcccg ttatcaacct tgcattcgta tcctaaatct cgtacttcct 1924321 ttgcgacaac agcttcaatg cccatcggcg ccgttgcaat tagtgtatac ttcttcatcg 1924381 tatcaccctg tcttttaaaa cttttctctt ttcaagataa aagctctcct tatacgggag 1924441 agcttgtttt catcatttta aatgtaagtg gtctaacgtt ctgtaagcca tgttttgttc 1924501 catcgtactg caaacggctc atcacctcgt actcaggcgg caatcatcta tctacagaaa 1924561 gcattctgtc cttctctccg ttgaattccg ttaagaaggt tcccctacca aaatttgggt 1924621 ttctcgctcg aggggtttac cgcgttccac tctcaccatt tctagtgaga cttcgtcact 1924681 gtggcacttt caaggatact cagccatatc cgaagacgta ggcttttttc ctgccgtcag 1924741 cctctaaaga ctgccctagc ttatgacttc gctaggcacg aacactacgg gcatctcagc 1924801 accgtgcgag catggacttt cctctacaga ttcaagatct gcagcgatta cccgaacgtt 1924861 aagaacatga attattatat aacaactgat tacaatttac aagcgccatt tttttcaagc 1924921 gtgatcaatc ataaagcttg ctgccaaaaa cgtgtttttc taagttagac agccgtttta 1924981 aaatatcaaa gtttgttgtg ttagattgca caggctgttt tttgctggct tcttcaagct 1925041 gttttttcag ctgcagattt tcctgctgca gttcttcaat ttcttgatgg aaggtttcat 1925101 aatccttaat aatcatatct aaaaatttgt caacgtcttc ttgcttgtag cctctaacgc 1925161 ctgttttaaa ttctttttcc aaaatttctt tcgcagaaag ctttacttta tcagcaagca 1925221 tctttttcac ctcgtatcgt gaatcatcac atatattttt tcagaaatct gtacggttgt 1925281 caaatttctc tctcattgtt agtagctgtc ttcctccact gtcactctca agtcatccat 1925341 tgtaataaag tagatgggat agccatcctg ttcgcgcctt ttttccgctg tcccaagcat 1925401 atacttaggg gagccttcct tttccgggtc atataaaagc agaagcccgt cggacttatc 1925461 aatgaagaac tgattttttt gtttgaattg aagcgggctt tcataaggac ggtgagtcag 1925521 gcttgcttca tagtctgcct gagccagaac tgcttcatac tgttctttat tcggttcttt 1925581 ccagttcttt tcctgctcgt aaaatggtgt gatgacagct acctttaagt cagggtattc 1925641 ctcctgcaaa tcatatgcag cttctgccgc ccacagctca actccaagct ggcccgaaat 1925701 taaaatccat tctaatcctt catccaaaaa agcaatcagc cggtttttaa tggctttttt 1925761 tatgtaatac agcgccttgt catcctgctt aaatatcccc agttcaaacg gtttatagcc 1925821 cgttattgcc aatactttca tcatttcacc tgctttaaaa aatggggctc ccgtgggccc 1925881 catttgttgt gctgcattgt ttacaccatc aagctgcacg ttttccatac tagtagtcgc 1925941 agcaaggttt tcctgcttga aaatgctgat gcgtagccgg gtcaacattt gagaaagtgt 1926001 gtggaaagta gtgaacgtgc tgaaaatgct ggtggtttac gtttgttgta tgctgtgggt 1926061 gaatgtgcgg cacgatagtc ttcgaaaacg tatggtgttc acagcaatga gtaggatgga 1926121 caattggcgc catcatatgc ggtctgcagt gatgcatgat aaaatcccct ttccataaac 1926181 tttattacaa tactaagtta tgaaaaataa ggggtacatg ttctgatgca aagacctatt 1926241 ttaaaagtgt gcaattaagc tgtctttaaa gtttgaaaac acaaaagcaa tcaaaaatac 1926301 cacaacaaag aacaagtaaa aaacaccctt atacatacca actctccctt taaaaataac 1926361 taacgtcatt ttacaggatt cgccgctatt ctacaacaaa atcaatgtga attcagcaaa 1926421 aaaaattcat ggcgaaacaa gtcgtctttt gcgctttccc ggggaatatt taagaggaat 1926481 atttcctctt tagccgggca attctcacat gcagtttttc agtttctttc tctgataagc 1926541 atgccgcatc gctaagcgat tgctctgcta cttgcaatgc ttttccgaat tcttttttct 1926601 tatgctcaaa atatttcgcg agctctatta cagcagcgta tctgcacttc tggttttgcg 1926661 agcgggacag cttttcccaa agcggcactg cttcttccaa gcggttttgt tttttgtaca 1926721 ggagcgataa atccagccgt gcactgtcct ggtcctcaaa cgatttttct ataagccttt 1926781 ccaactgctt gatcgcttgg tccgtttctt tatgagccat aaaccatttc gccatagcat 1926841 aggcttcact gtgttctttt ggcgcatgtg attctgaaag gattttttta gacatatgga 1926901 tgtacaatga aatgagtgat aacacatcca tttcattatg atgcaggaca ccttttaaaa 1926961 gatccggctc ttgcgccttg ataaaatgaa agtaaagcat tggcgccaag tagcccggtg 1927021 tgtcttctag cctgcggatg ccgagctcct ctttttcaac cgtgccaaga gatacacggt 1927081 ccattttgtg tttccacagg cgtctagctc catgcaaaag atcaaagtgg ccaaactccg 1927141 gaagcttcgg aagtctgtca cggatcaagg tgtgccttgt tttcacctgc ggccaatcaa 1927201 aggctttgcc gttgtaggtc acaagtgatg taatgtcaac ctcgcttaaa aagctttggt 1927261 acaaggcgac ttcgttcccc ggtttgggca aaagatgctg tttgactgtc actcggtctt 1927321 catatactct cgcatgccca agcaaaaaaa tggtattccc agctccaccc ccaagaccgg 1927381 ttgtttctgt atcaaagaaa aagaggttgt ttttgttata cccttttgct gacaatgtat 1927441 gcgacaggcc gctttgattc cacagtgtga tcacttcctc aagctcagaa aagctgtata 1927501 acccatggcg gtgagaaagc ggatattcta cttctctgat gaggcaatat tcatcttcga 1927561 agatgaaagg cttcatgcca aaagcctccc actcttctaa aaacgggatg tcatcaaagt 1927621 ggttttcttg tttgcctgct tctatttttt gttctccttc gtcgagcgcc atgtgctttt 1927681 tcatccgttg gagtttccct tttaatgaca tatccggcct ccctccttac gacatttgat 1927741 ccaacagctg caaaattctt tcctttgctt ttatcccttc tatttccgta cctatacaag 1927801 acggacagcc gtcatgacaa ggacaatgtg taatcagttg tttcgccgct tcattaatgt 1927861 ctgaaaaacg tttaaagact tcctccgcca aaccgatacc gcccggataa tgatcatata 1927921 aaaatatggt tggcaatccg gtatgggctg ctttaatttg agaaacaaca tgaacatcat 1927981 ttcgatcaca catgatatac acagggacaa tatgctgcag cacattcgag atgccaagaa 1928041 gcagctgttc cagtgtcttt tccccgatgt cttcatccgc tgttttgatt tcgagccaag 1928101 ctgcacttgt atgcagttct tcttccggca aatgaatagg tccagaccca atattttcaa 1928161 aagtggtcat ttttattttt ttaaaaatgg tcggcagggc attgacagtg acgtctccgt 1928221 agtgcaatga cgtacggctt ttttctttcg ttttatcgat ttctaatacc ttcagctgaa 1928281 ctgccaggtt tgcatccgta taatattcga catcgacttt tctgacatac gcctttttat 1928341 ggtcccaatc gagcttctca acttgatact gaacgccttc atgcaaataa atcgcttcat 1928401 catgcaaaag cgtcatcgca ctaaaacggt ccatttcacc gataatcctt acatttgcaa 1928461 tatccgactg atcaactata acgacatttt cctgggaggc ggaacgcaaa ctgatgtttg 1928521 acgcagggaa cgactcactt gcccaatggt accgttcgcc gttgcggtga agaacagcct 1928581 cttcctgaag atactcaaga atatcactga cttccatggc tccaaattct tcatcagctc 1928641 taaaaggaag ctcataagcc gcacacttta agtggtctac taaaataatc aaattctccg 1928701 gattgattct tgcagattcc ggcgaacgat taaagaaata ttcaggatgc cgcacaatat 1928761 attggtcaat cggtgttgaa ttggctacca tgataatcaa agattcaccg tgtcttctgc 1928821 cggctcgtcc cgcctgctgc caagcacttg caacacttcc gggatacccc gtcattacac 1928881 acacttgcag ctggccgata tcaacaccaa gctctaaggc attcgtactg accactccta 1928941 aaatgtcgcc ttctctcagt cctctttcga tttctcttcg ctctttcggc agatagcctc 1929001 cccgatagcc tctgattgat tttgttccaa tctctttttt cacaagctcc tgaatatggc 1929061 ttaaaataat ttccacccga actctgcttc tggcaaaaac aatggtctgc actttgtttt 1929121 taaggaactc tttcgccagt tcattcactt ctgcggttgc gctccttcta atattcagcg 1929181 gtttgttcac aattggcgga ttgtaaaaca caaaatgctt gcgtccgctc ggtgcgccgt 1929241 tgtcatcgac cagccgcatc ggtttgcctg tcagctgctc tcccaattcc tttgggttgg 1929301 caatcgttgc ggaagtacaa ataaaaactg gatcacttcc ataaaaccgg cagatccgct 1929361 tcagccgccg gatcacattt gccacatggc tgccgaacac acctcgatac gtatgaagct 1929421 catcgatgac gatatactta aggttttcaa acaaactgac ccatttcgta tgatgcggta 1929481 gaatggcaga atgcagcata tcggggtttg taatgacaat atgacctgct tttctcacct 1929541 tttgtctgat tgccggagac gtatccccgt catatgtaaa gcttttaata tcaatgccca 1929601 tttcatcaat aatttcattt agctcgctct tttggtcttg tgccagcgct ttagtcggaa 1929661 ataaatataa cgcccggttt gtttcatctt gggcgatgga ctgcaggact gggaggttgt 1929721 agcataacgt ttttcctgat gctgttggcg ttacggtaac gatgctctct cctttttgca 1929781 catattgaaa agcggaatat tggtgagtat atagttcatc aatgcccctt ttcgaaaggg 1929841 ccgctttgat tctctcgtct atactttcgg gcataggcct tgtttttgct tcccgaggct 1929901 caatttcatg ccaattcaca acgttttcat ttccttttaa atcagaaatg agttcagtca 1929961 gtgatttctt tttcattctt tacacctctt tgtcaagtac agtttaccga atatttgttt 1930021 gcatggctag gtgcaaattt tatacagttg aataaaaaaa gcaaggcata cgccctgctt 1930081 atttcgcttt tattgtaaag agctttgatt cgcctttacg agcagccttt tcgcctgccg 1930141 ataccattga tcctacagcc tcaccattca ttataacgat tgggatgact gtgctgctcg 1930201 ctttttcttt tattaattcc aaatcacatg taatcagcgg gtcaccgacc ttcactttat 1930261 ccccttcttt aatgtgggca gtaaatcctt ctccgttcat attgactgtc tccagcccga 1930321 catgaattaa cagctcaatt cccgagcgag tccgaatgcc aacggcgtgt ttggtgtgga 1930381 aaatctgaat gacttcacct tcagcgggag aaacgatttc accgctagaa ggttccaccg 1930441 ctattccttc tcccatcatt ttctgtgaaa aaacagggtc cggtacatct gacaggtcca 1930501 ttactgtacc gtctgccgga gaataaataa cctcttctgt caccttttcc tgaattttgc 1930561 ccattccgaa taattttttc agcaatgtat tttctccctt ctcattcact tcaaccgtta 1930621 tcccttcatt caccactatt taaccacact ttcaattttg cttcaattta taacaacatc 1930681 tggcatagac gcataatctg gttaaaaaag gcggtggcga tattggaatt ccatgatgac 1930741 aaaaagaacg aactgcaaaa gaaagaagaa atcataacgg aggcaatcga cactcttttt 1930801 caatcctcag cgttcggcaa ccttataaac ggatttcaga acctaatcaa ctcgagttta 1930861 aaggatgtgc agacgaccat acatgtcaga gaaagagata ctgggctgta tatcgatatt 1930921 accattccgg cgacgtttcg agatggcgag atcgtcgttg atgttaaatc gaggtatctc 1930981 catgtaacac tccaagaaaa acagaaacac caaaatgagg ctacctttac aagcatgaca 1931041 agaacggttc agctgcctta tgaagttcgc caagaagata tggaaacgtc ttggaacgag 1931101 cagacaatga cacttttctt tccaaaaaat aagcatgaat gaacgattca ttcatgcttc 1931161 tatcatttaa aaaagctggt aaatcccttt attaaagatc cgacctgatt cattgcactc 1931221 attacttgac ctgtcgtatc catcatttta ttaaaatcaa attgcccatt ggcttttttg 1931281 aactgcgaca taatgctttg aaattgtgaa ggctgctgtt gattaggcct tgggatagga 1931341 taagggttag aaaatacagg cggctgcata ggcataggct ggatcggagc ataaggctga 1931401 taataatcct gctgtccata atgctgctga ggcagttgtt gctctaaata accgggtgca 1931461 gcctgctgat aatatccttg catatgctga ggataataat agcccatttg ccgaggatag 1931521 cttcgagagc tcccgttcat tgcgattccc ccctaaacac aacatatttc tcttctatat 1931581 atgtatgaat gacttctatt gtttgtgtca caagtgatga ttagcatttg tcaaattgtg 1931641 tcgaaagttt aaatttttta aaaacagaaa aaagtcgaat cattatggta ccatattttc 1931701 aatacagatg agaggggatg caccataatg aacgtatcat acttaagcaa acgttttgca 1931761 gaaatgaaga aatatgaaac agactgtatg aataaactga tggactttgc caagttcctc 1931821 tatattcaag gacatctcag cataactgag tttcgtaaca gtatgaaggt tctcgaagca 1931881 aatggagcag aaagcccggc atatgagatg aattaacgtc cggcccccta taaaaacgaa 1931941 aagaagacag ccttttaccg gctgtcttct cttgcaattt catcctttac tgcgtgcaat 1932001 gtataaagga ctgactcagt gatgtccttg aatcgttttt tatgaatatg atgaacataa 1932061 gattgaagga ccaattccag gaaattatcc tttacggcct caatttgctc tttatgcaca 1932121 tattttggcc ggcggacttt tatcaattca agagcaccct ctgcccagcg agcagccagt 1932181 tcatcattct cttcaactgc aggctttatc gtctcaaaaa aatcataaga atgattactg 1932241 ttttttcctt cctgataccg atcagcgcct ttttcagcaa cttcaatcat ttgctcggtc 1932301 atttccagca aagtttgtga tagcaatatc tttcacctca atgcctatcg taccaaattt 1932361 cactcacaaa ttcagccgat gcggtatacc ttctcaaacg catacctgtg ttcaggcgat 1932421 tgatacagct catttataca aatatgaaga tctatgattt cttcttcgag cacacttagg 1932481 cgatcgttct ccgtttcccg catctcagcc tctaatgcat ttacagaatg attcaggctt 1932541 tgctcagctc gcgttaattc atcttctata tcagaaagca tacggagaat atctgtcttg 1932601 catacataac cggacattcg tgtacctccc tttccttgtc tctcccggtt aacattcttt 1932661 gctctcaagg ctctttcctt cctcatgaca aaactagaag caaatcgcca aacaaacagg 1932721 tattccacga aaagctgaag ttttcgacaa aaacacccgc aaaaattgta tgatcctcct 1932781 cattaatgca aacgatactt gtgaggaggt gccgtatgaa aacaagaccg aaaaaagccg 1932841 gccagcaaaa aaagactgaa tcaaaggcaa tcgattcttt agataaaaaa ttaggcggcc 1932901 cgaaccgccc ttctacgtaa gaagcaagga atttccttgc ttctttattt tttcagccac 1932961 tgctccaccg caaaaagcgc atgaagctgg cgctttttat gtaaatacca gtctgtcaat 1933021 tcaatctgct tcggcaattc ctcgcgccta aagaacgttt tctttatctt tccatgaaac 1933081 caatctgttt tcgttccgtc taatgagtgg attaactcag ggtagcatgt ccttagcata 1933141 ggagatgttc tttttgtaat cccgatcatc ttttccatat caaaacggga acctgtgtgc 1933201 ggcactgtgt gcaaaaagtg ataaaaagag gagaacaatt ctggcttgaa cagcaattga 1933261 gacagctgct ttcccagcct tatcctttcc tccgcctttg aaaagcgttt cactgaaatg 1933321 ccgtaaaaaa acccatttga ggaaggaaaa ataacggtgt taaaatgaaa ccagtcactt 1933381 aaataaaaag gaatcgtgtc aaaaacattc tttttaaacg aaggattttg tataataggt 1933441 gtttggatag tgttttgttc atttataatg agggcataca ttagccgctc cgtatttcgc 1933501 tcatgccaaa aacgggtcca ttcttccgac ataaattgtg agacgccaaa cacatgcagc 1933561 agatgaaaca gcggtttccc aactcttttt gaccagtggt ataaaagaag ctgcggatag 1933621 gcatccgaaa aaataagcca gttcgctctt tcataggcta aaaagaacca tttttgctgt 1933681 ctctcacgga gtccaagctg aaacagactg ccttttaagt cagtcattga ccagccggca 1933741 ttacgagaaa cgaaagaagc caaaagcgac catttgattt ccggatgacg gtcgtaaaat 1933801 gctttataag catttgttct tgaaatgtta tccgcgtttt tcatttttgt ctgccgctca 1933861 atccggctca gaagctttct gatggcctgt tgttcttgca cgttcattca cttccgtcat 1933921 gattagttta ataaggagga tgagaaagtg attcggtatc ctaatggaaa aacatttcag 1933981 ccgaaacatt cggtttcatc ccaaaacagt cagaaaaggg ccccgtctta cagtaatcgc 1934041 ggaatgaccc tcgaagatga cttaaacgaa acgaataagt attatctgac aaaccaaatt 1934101 gccgttatac acaaaaagcc gacacctgtt caaattgtaa atgtccatta tccaaaaaga 1934161 agtgccgcag tgattaaaga agcttacttt aaacaatcat cgacaacaga ctacaatggg 1934221 atttacaaag ggcggtatat tgattttgag gcgaaagaaa cgaaaaacaa gacctctttc 1934281 cccctgcaga attttcatga ccatcaaatc gagcatatga agcaggtaaa ggctcaagac 1934341 ggtatttgtt ttgttattat atccgctttc gaccaggttt attttttgga agccgataag 1934401 ctgttttatt tctgggacag aaaagaaaaa aacggcagaa aatcaattcg aaaagatgag 1934461 ttggaagaaa cagcttatcc gatttctctt ggatacgcac ccagaattga ttatattagt 1934521 attattgaac agctttattt ttcgccatca tctggtgcga aaggttgatt aacgaaaggt 1934581 tgagatgtta tgtcagatca atttaacagc cgtgaagctc gacgaaaagc gaacagcaaa 1934641 tcgagtcctt caccgaaaaa aggcaagaaa cgaaaaaagg gcggattgtt taaaaagacc 1934701 cttttcactt tactcattct gtttgtttta ggcgtagtcg gcggtgctgt tacatttgcc 1934761 gtcatggttt ctgatgcgcc gtcccttgat gaaagcaaat tgaagacgcc ttattcatca 1934821 acgatttatg ataaaaatgg aaaagagatc gccgaagtcg gcgccgaaaa acggacctac 1934881 gtctcgatag atgaaattcc cgatgttgta aaagaagcct ttatcgcgac agaagacgct 1934941 cgtttttatg agcaccacgg gattgaccct gtccgtatcg gcggtgcatt agttgccaac 1935001 tttaaagacg gcttcggggc tgaaggcgga agtacgatca cccagcaggt cgtcaaaaac 1935061 tcccttcttt cacatcagaa gacgttgaaa cggaaggtgc aggaagtatg gctttcgatt 1935121 cagctggagc gcaattactc taaagatgaa attttagaaa tgtatttaaa ccggatttat 1935181 ttttctccta gagcatacgg aatcggaaaa gcggcggaag aatttttcgg cgttactgat 1935241 ttaagcaaat tgactgtcga acaggctgcg acgcttgcag gaatgccgca gagcccaaca 1935301 gcgtacaacc cggtcaaaaa cccggataaa gcggaaaaac gacggaacat cgtactcagt 1935361 ctgatgaaaa agcaaggatt tatttctgat tctcaatata acaaagcgaa aaaagtggca 1935421 gtgaaagacg aaggcgtcgt gtcacagaag gaatatgaaa aagcaagtac aaacaaatac 1935481 agcgcatttg ttgaagaggt tatgaaggaa attgatgaaa aatctgatgt cgatccatct 1935541 gctgacggat taaagatcta tacgacatta gatacaaaag cacaagataa actagatgaa 1935601 ttaatggacg gagacaccgt cggatttact gaaggcatgc agggcggtgt gacgcttctc 1935661 gataccaaaa acggagaagt ccgagcgatt ggtgcgggac gcaatcagcc tgtcggaggc 1935721 tttaactatg ctactcaaac taaggcacag cctggttcga ccataaaacc gattttggac 1935781 tacggaccag ttattgaaaa taagaaatgg tccacatacg aacaaattga tgactcagct 1935841 tatacgtatt ctaacggaaa accgattcgt gattgggacc gcaaatatct agggcctatc 1935901 tcaatgcgtt acgctctggc ccaatcaaga aatatacctg ctttaaaagc attccaggca 1935961 gtcggtaaag atactgctgt agactttgca aatggactcg ggcttggttt aacaaaagat 1936021 aatgtaacag aggcctattc tattggcggt ttcggtggga acgatggtgt ttctcctctg 1936081 acaatggcag gtgcatacag cgcgtttgga aataacggaa cgtataatga accgcatttt 1936141 gtaaaatcta tcgaatttaa cgatggcacg aagcttgact taacaccaaa atcaaaatca 1936201 gccatgagtg attatactgc gtttatgatt acagatatgc tgaaaacagc tgtgaagaca 1936261 ggtactggac agcttgcaca agtacctggt gtagaagttg caggaaaaac aggaacgact 1936321 aactttgatg ataatgaagt caaaaggtac aatatcgcta gcggtggcgc ccgagattct 1936381 tggttcgttg gctacacacc gcaatataca gctgccgtct ggacgggaat gggagaaaac 1936441 gaggctggaa agaaatcact ttcagctgaa gagcaaaaag ttgcaaagcg catcttcgcc 1936501 cagctcatcg ccgatgtcga tgacggaagc ggatcatttg agaagcctga cagcgtagtg 1936561 gaagccaccg tagaaaaagg ttctaatccg gcaaaactgg cagggccaaa tacgccaagc 1936621 gataagaagc tcacagagta ctttgttaaa ggcacagctc cttctactgt ttctaaaaca 1936681 tatgagaaag aagaaaaaga ggaaacagct aaactgtctg gtttaaacgt gaaatacgat 1936741 aaagacaatc aatctttaac gttaagctgg aattacgacg gagatgcgac ctttgctgtt 1936801 aagcaatctg ttgacggcgg cagctactcg gaaattcaaa acagctctgc aaaagaggca 1936861 gttatttcgg gtgtgcagcc aggatctgta tacaaattcg aagtaacagc cgtcagtgat 1936921 gatggcaaaa gtacagcttc cacatcttat gaggtgccaa aagctgaaga cgatgaagat 1936981 aaaaaagacc agcaacaaac ggatgatgaa aaacaagatg atgagaagac tcaggatgat 1937041 acacaaactg atgattctca aaaagatgac ggtcagacgg atcaagatca gacagatgat 1937101 tcaacaaacg atcaagacaa aaaacaagac aatacgaaca ccaatccgtc cgacaacaat 1937161 aaccaagacc aatcaaacga taatgataac gacaacagta acaaccagga tacgtcggat 1937221 ggtgattcga actctggtaa gaatgattca acaggttctg acacgaataa aaataaaaca 1937281 gacacatcta ataaaacaca aacaaactca tcatccattg aaaaaacaaa ttaaacaaaa 1937341 aagccgtcac ctttggggtg atggcttttt tggtacacaa taaaaaacct cccgttttaa 1937401 caggaggttt tatcgattca tcgcatgata tttataaaaa tgctttttca tttcggtaat 1937461 cagctcatca agctgaataa agcaatggta ttgggtcggc ttaagaagaa taaattccac 1937521 tcgttcagcc caattaatcg gctttgcggg atatgatttc tccctcagtt cttgccaatc 1937581 gagcgatttc accggctcac ctgctgtcca atgtaacgaa gccagcaaac acacaatgcc 1937641 ctttaacatt tcgttttggt cacatctcga ttttcgtgtt tgaaagactg ggagaagtga 1937701 tgctttgatg tcatcccaca cttcaaataa aagcggaacg tatttcccgc tgtcctccca 1937761 tggcaaatcg ccttgtaatt ccgtgcagaa atcaaaatac acgggattgg tctgcaaggt 1937821 tttcttcata tccgaggaac tcttctggcc aagactgcgc aagtattgct cataggaagc 1937881 caacacttct tttgcttgcg tcatcgtttc accagtcctt ttttatccct cttctgccct 1937941 tctctgcaca aagaaagcag cggacactcc gcacagcgcg gagattgggc tttacagtga 1938001 tatctgccga agaaaataag ccggtgatgc gtaacggacc aatcttcttt gggaaccttg 1938061 cgcatcagcg tcttttcaac ttccagaacc gagtccttcc accggcaaat gcccaatcgt 1938121 ttgctgactc tctccacatg ggtatctacg gctatggccg gcacgccaaa cgcaacggat 1938181 accactacgt ttgcggtctt tctcccgacc cctggcagtt tgacaagctc atcgcggtct 1938241 ctcggcactt ctccgccgta atcttcaata atcattttac tcagcttttg aatatttttc 1938301 gctttattac gatataaacc gattgattta atatcctgct gaagctcttc cagcggaaca 1938361 gccaaatagt cttccggccg tttatatttt tggaataatg ttttggtcac tctgtttaca 1938421 agtgcatctg tacattgcgc agataaagca acagccacca ctaattcaaa aggattggaa 1938481 tgaaccagtt cacactccgc atgaggaaac atgtcaccta tcttgtctaa acagaattca 1938541 atttgtttta gatttaacac gattgtcacc ttttcacttt attgttcaag ccaattgtaa 1938601 aaaggaacct gccttttata ctctttttgc ggttcattct gctttgcttg tacacgccgg 1938661 aatttttggc tgtgtatttt tgcctgctcc acagttttaa gcccattttt cttccattca 1938721 aacaaaatcc ggtcaatgta gcggaaactg agttttcctg atagtacagc ctcttttaac 1938781 gcgtgtttga tcagttgtgc gtcatgctga tcctggtcct gccagatcgc cagcgtttca 1938841 cactccaaag gcgataacgg tcttgcgaac tcttcctcaa aaatggtata aaggcttttt 1938901 tgttcccctt ctgcttttct ttcctgtgtt tgattctgtg caagctgaat atactcgtac 1938961 agcttgcccc ataaaggctg aagagaatat ttctcaaatt tgatgccgtt ttgatcctcg 1939021 cattcttcaa taaacagaaa gcctttttga ataaacatcc gcaatctgtt tgtacattct 1939081 tcaacagaaa ttgacatacc ttcctgcagc tgattcggtg taggaaaata tgatcctttt 1939141 tctaaatgca ttttaatttt taacagcaga ataagttctg tttcattaag cccaagctgt 1939201 ttataatgcg tgagcagaag attggggatg gttgatgttc cctgctcctg catatcaata 1939261 aattgctgtt ttttcatcgt cacacctctt actgtaaagg attgtgattg cccctttact 1939321 gtaaaaagtc tcccttgcag gagactcttt tttgtttcat ttgaatgtat tacggataca 1939381 gacggtttaa cagtcttggg aacggaatcg tttcacgaac gtgaggcgct ccgctgatcc 1939441 aagctactgt ccgctctaat ccaaggccga agccggaatg aggaactgat ccatattttc 1939501 taagttcagc ataccattta taagcgtcag aatccagtcc atgttcttta agacgcgatt 1939561 ccaaaagttc catatcgtga atccgttcag acccgccgat gatttctcca tagccttccg 1939621 gcgcaatcaa gtcagcgcaa agcacaacgt cctcacggtc agaagccggc tgcatataga 1939681 acggttttaa ggacgtcgga tagcgagtga tgaataccgg tttgtcataa tgttcagcaa 1939741 tcgctgtttc atgaggcgct ccgaaatcat ctccccactc gatatcgtca aagccttttt 1939801 ctttcagaaa ttcaatcgct tcatcatacg taattcttgg gaacggggct ttgatttgct 1939861 caagttttga cgtgtctctt cccaatgtgt ttagttcaat tttgcaattt ttaagaactg 1939921 attgcacgat gaaagaaacg taattttcct gtacttgaag gttttcttca aattctacaa 1939981 acgccatttc cggttcgatc atccagaatt cgattaagtg acgctttgtt ttagactttt 1940041 ccgctctgaa tgtcggtccg aaagagaata cttttcctaa agccattgcc gcagcttcca 1940101 tgtagagctg tccgctttga gacagatatg catcttcatc aaagtacttt gtcgcaaaga 1940161 gttctgttgt tccttcaggt gcgcttccag tcaaaatcgg cggatccact tttacgaagc 1940221 cttcgttatt aaagaattcg taagtcgcgc gaatgatttc attacggatt ttcatgatcg 1940281 catgctggcg ctttgaacgc agccataaat gtctgtgatc catcaaaaat tccgttccgt 1940341 gttcttttgg tgtaattgga taatcggtcg cttcgtgaat gacttcaata tctgtcacag 1940401 caagttcata tccaagcgga gaacgctcgt cctctttgac aatccctttt atatagagcg 1940461 acgtttcctg cgtcactgat ttagctgttt ggaaaatgct ttcttccact tccgctttta 1940521 ctacgacacc ctgaataaaa ccggtaccgt cccgaagctg taaaaacgca attttcccgc 1940581 ttgaacgctt attagcgacc caagctccga tcgttacttc ctcacctacg tgcttgtaca 1940641 cttggttgat tgttgttttc aacatatttc cctccaaaac aagaaagaca ttcggaagct 1940701 cattgccccg cgaactcttt tatcatcact ttattatacc cgctcttaac taaccgggtc 1940761 aatgcagata aaaagcggct tttctgtcag ccgctttttg atctgttagc tatgtttttc 1940821 tacaaaacgc ttgattcttt caatggcttc ttcaagaaga tctaacgatg ttgcataaga 1940881 aagacggaca ttctcaggag agccaaatcc ggatcctgga acaatcgcaa ctttttcctc 1940941 ctcgagaagc gctttaacaa attcatctac atctttgaaa ccgcaagatt gagctgcctc 1941001 ttttgcattt gggaacaagt aaaaagcacc ttccggcttc acgcagctga accctgggat 1941061 ttctatgagc tttgcataga tcgtatttaa tctatgttca aatgcttctc tcatttcttc 1941121 caatggctca gaaggcccgt tataagcagc aatcgctccg tattgtgcga ttgatgtcgg 1941181 gtttgacgtg ctgtggcttg caaggttcgt catcgcttta ataatgtctt cagagcctgc 1941241 cgcataaccg attctccagc ctgtcatgct gtgggacttc gatacgccgt ttataatgac 1941301 cgtttgctct ttcagtctgt ctgacagctg tgcaatggaa acatgtttct ttccgccgta 1941361 tgtaagtttt tcataaattt catctgacac aatcaagata tcatgttcaa ggcacacttc 1941421 accgagcgca gatagttctt cttccgtata catgacacca gtcgggttgc ttggagagtt 1941481 aataacgatt gcttttgttt tttccgtaat tgcatttttc agctgctcag gcgaaatttt 1941541 gaagtgattt tcctcaagcc cttctacata aacaggcttt ccgccagcga gtttcacctg 1941601 ctccgggtag cttacccagt aaggcgttgg aataataact tcatcttctt catccaaaat 1941661 cacttggaaa agggtataca gagcatgttt ggcaccagtg cagacaataa tttgagacgg 1941721 tttgtattca atattctggt cgcgtttaaa tttctctgca atgctgtttt tcagttcagc 1941781 caaaccaccg gaaggcgtgt atttcgtatg gccctcgttc atcgaacgca cagcggcatc 1941841 aataatatgc tgcggtgtat tgaagtcagg ctcgcctgct cctaagccga tgacatcatg 1941901 gcctgcggct ttcagttctt tcgctttcgc tgtgattgcc agtgtggttg atggtgttaa 1941961 tgcggatact ctttttgcca gtttcaactt gaactccccc taattcgtct taaggcgtga 1942021 tatttttgag aatctttcca gttgtaaagt ccacataact taaactgtat tgcccttctt 1942081 tgtctaagta cgtcacttcc caaagcagga cgtttccttc tcttgccaga tgaacctctt 1942141 tttgctttga aaccagccct tcatccttta tgattttcgc cgctttgtct tcagagattc 1942201 cctctttcgc ttcttttgag agaatttttg cttttttatc agcaggaacc cagacatata 1942261 atgcagtgcc ttttttatcc gttcccttta caacataata tttttctttt ccgacaaatg 1942321 tttcgacttg atcaacatgg gcgagatcgg tttctttttt agcttcagca gctgctgctt 1942381 cgtgcccctc ttccttttgt gccatggctg atttataaat gcttgccgag acaagaagta 1942441 ctgctaaaaa aataatacca aaaatgacgg taaatattaa tgcttttttt ctcatcttct 1942501 cacctacgta cgataaatgg taaaaacggc ttggtttttg ttttcttcat ccagcgcaag 1942561 gccgaacatc agattgtctc ttttcagtgt acgattcaat gtgtccacaa ttttatacag 1942621 atcatcagaa tgctctacat taattgttga aagaatttcg attttacttt ccattttttc 1942681 atcctccagt ttgaacaaat attgttagtc atactccatt tcaggacacg ccatactagt 1942741 atcacagagc gggaaatccg cttttaaata aaacaccatc ctactcccac accgcaaaag 1942801 ccgctttatg cggcttttat tctttttccc ctgcaacata agcttcaagc tcgctgtcag 1942861 tcatttcgga tactgaggtt gtcggcaagg catcaagaaa cagccggccg taaccagcgg 1942921 ttttaatccg tctgtccaat ataataatcg ttcccttgtc tcccgcagaa cgcagcaagc 1942981 gtccgattcc ttgcctgaag gtcagcacag cttccggtaa tgacactgtt tgaaacggat 1943041 tctttccttt tttgcgggca agctcacatt ttgcagcatg aagcgggtga tcaggggacc 1943101 ggaatgggag cctcacgatc attactgtcg tcagctcatc accagggaaa tcaacgcctt 1943161 cccaaaaatg atttgttccg agcaggatcg cctgattgga tgttttaaaa gtcttcatca 1943221 gtttgccggg acttccgcct gtaatccctt gtgccaagag ctgaatgccg gaagcactca 1943281 tgttatgctt aagctcctgg tgaacctttt tcagcatatc atgggatgta aacagcacaa 1943341 ggattttagg ctgtttttcc tttgccatca gttcgatata acgggctgta tcctgtataa 1943401 attcaggttg ccctgtatcc tgaattgatt tcatttcttt tggaatcatc acctgcatac 1943461 gctcatcgta agaaaagggt gactcaattc tcattgtccg cgggaaaaag tcactcagtc 1943521 ccagtcgttc aatcataaat tgaaaagaac cttcgactgt aagagttgca gatgtcagca 1943581 ccacactatt tttgcgcgcg aaaaactgat cagccagaag ttcaccaggt tcaagaggct 1943641 gtgcgtaaat ggccactgca tttttcgcac cctttgcatc tatttcaatc caaaccgctt 1943701 catcgtcatc agagccaaag aagagcttct gcaacgtctg acagtaatgc tgcaagcctt 1943761 tcatgcttct ttggtattca tcggctaaaa agacggtttt gctcttcatg cccttcaaat 1943821 gtttttccat aagggatgac tgcgcctcaa aaagctgctg caaatgtgtc agcatggaac 1943881 aaagcctctc cgcaccatct gttaagatcg accagctttt atcctggctt tctttgttca 1943941 ccttaaacac tagacggttt aagtcttctt taggttttct tcgtttgaca aaagaatgta 1944001 cagagctaaa gaaagcatca ctttctgctt gaacgtgctg aagccactct tccaattcga 1944061 aaaatgaatc aaccggcagg ctgtttcgct ggaatagctg tctcatcttt tttagaagtc 1944121 cctgctcctt cagagtgccg attctgctca atttcgtatg caattctatg tacgtggctc 1944181 ttttccctaa atgttcgctt gccgcacgtt caaaatggtg tgcttcatca ataataaatg 1944241 tgccgctttc gggaagcctt tttttatggc tgccttcatc ggtcagcaaa agagaatgat 1944301 tggtgatcac caaatcggaa cgcatagcaa tctgtttggc ccgctcgtaa aaaccgatca 1944361 catgctcact gcgacttctt ttataggagt catcgtcata agccaatctg tcccacagca 1944421 attttccgcc tgaaggcaaa ttcagttccg ctacatctcc tgtatttgtc tctgtcagcc 1944481 aaacaagaag ctgtgccttt gtcagtacgg catcataatt atcatcttct tcatgaagca 1944541 cctgctcaaa tttatacagg cataaataat gcgattgccc ttttaaaatc gccgctgtta 1944601 ccggaaatgg aaacagatct tggacaatcg gcaaatcctt tgtgagaatc tgctgctgta 1944661 aaagcgtcga atacgtgctg attatgaccg gcttttttga tttcttggca aaaagcgcag 1944721 ccggaataag atagccaatc gtttttccga tgcctggagg agcttcaatc agcgcatgct 1944781 cacgattggc aaacgcatca gccacctctc tcatcatcat catttggccg tctctttttt 1944841 catacccagg cattaactct gacagcgctt tttcatttcc cgcttcccag ctttcgatct 1944901 caaatgagaa gttctcgtcc tcatttatac gaacatcgat agcttcaggt tctctgacag 1944961 aaaacgaaga aaagcgcgta tagcccggta tctcggtatg tctgttttca ttaatgaaca 1945021 tatccaacaa atgcgtcaga tcactgatga aatgctgcga aagccttctt aactgcttta 1945081 atgtcggata aggaagctgc cgcagctttt caaggatttc caaaaaaata agccctgtca 1945141 cttcagcatc gctgtcagcc cggtgcggct gatcatgccg cagctgaagc tcctcgctta 1945201 attccgtcag cttataccct tcaaatcccg gaaaaacaat gcgtgagagc tcgacagtat 1945261 caagcacttc acaatctggg agctgaaagc ccgccttatg tagctcatac ttgacaaatc 1945321 caaggtcaaa atggatattg tgggcgacaa aataagcgcc gtcaagcaat tggaatactt 1945381 cttcagcaac tgcttcaaat ggctgttcat tctcgaccat ttgattagag attccagtaa 1945441 gctgctcaat aaaagcaggg attgatttat ttggattaat gtattttgaa aaccgctcag 1945501 taatttgtcc attttcgatt acaaccgctg cgatttgtat gattttatcg cctttcttcg 1945561 gcgaattccc tgttgtctct acatctataa caacgaaccg ttgcttattc attaaaatgg 1945621 acacctcaat tcttgcatac gacaaaagtg taacacgttt tgtacggaaa tggagcggca 1945681 aaaccgtttt actctcaaaa tcttaaaaga aaacccccga taaagggggc ttttcttcta 1945741 caaaattgta cgggctggtt cgttccccag catttgttca attttgtttt gatcattcag 1945801 aacagccact ttcggctcat ggcttgccgc ttcttgatca gacatcattt tgtaggaaat 1945861 aataatgacc ttatctcctt cctgcacaag gcgtgcggct gcaccgttta agcatatgac 1945921 gccgcttccc cgtttaccag gaataatata cgtttcaaga cgtgctccat tattattatt 1945981 cacaatttgt actttttcat taggaagcat tcccacagca tcaatgagat cttcatcaat 1946041 tgtaatgctt cccacatagt tcaggtttgc ttccgtaaca gttgccctgt gaagtttgcc 1946101 gctcatcatt gttcgataca tattatattc tctccatttc tcgaatatca ataatgatat 1946161 tatctattaa acgcgctttt gaaaaagcaa ctgcaacagc gagaatcatc tttccagcaa 1946221 tttcattcac aggctcgagt tccggatagg aataaagctc tacatagtct atggttccgc 1946281 tagtcgtttc aatgatatct tttgcagctt ttatcaccgc ttcaggatct ctttcaccgg 1946341 cttggacaag ttccgcactt gtttgaaggg cccgatacag cttaggcgct tcttttcttt 1946401 cctcagctgt taagtataca ttgcgagagc ttttggctaa gccgtcttcc tctctgaccg 1946461 tatcgacagg aaccaattca atatccatga agaagtcgct gattaaccca tcaacaacag 1946521 ctacctgctg cgcatctttt aaaccgaaat aggcacgagt cggcttgact agattgaaaa 1946581 gcttcgtcag tacgatcgcg accccgtcaa aatgtccttc tcttgagcgc ccgcataaca 1946641 cgtctgtgcg tctttctaca tgaatcgtga cattcttttc accgggatac atatcatgag 1946701 catctggcgt aaaaagaata tcgactccgg cgttttctgc aagagctgca tcccgctcaa 1946761 tatcgcgcgg atatgcttca aaatcttcat tagggccgaa ttgtgcagga ttcacaaaaa 1946821 tactcataat aacggcgtcg ttttcttgtc ttgctttgtc tgctaaggtt aaatgcccct 1946881 catgcagaaa ccccatcgtc ggaacaaatc cgattgactt gccctctgaa tggtattgtt 1946941 ttatggcttc tttcagctgt gaaatatcag taatctgtct catcttattt tcccccgtac 1947001 aagccgtcaa gcactgtctg gttcatttga aaggaatgct tttgttcagg gaaagcacga 1947061 tgtcttacat cctgaacata tccgctgatt gctgtttcga tggtttcatc aatgcgcgta 1947121 tattgcttta caaatttagg tgttctctca acaccgtggc cgataatatc atgataaacg 1947181 agaacttgtc cgtccgcttt cacaccagcc ccgattccaa tgaccggtat gcttagcgtc 1947241 tcggcaattt tggctgtgag ttctgccggc acacattcca gcacaagcat catagctcct 1947301 gcttcttcgc attttatact gtcttctatt aattttttgg cgctttgttc gtctttgccc 1947361 tgtactttat agccgcccag tacgccgact gactgcggtg tcaaacctaa gtgactgact 1947421 actggaatgc ctccaagcgt caatgcgcga atggattcaa acacgccttc tccgccctca 1947481 agcttcagtg cgtcagctcc gctttcctga acgatagccg ctgcattttt cagcgtatct 1947541 tccttagaca ggtgataaga cataaacggc atatctgtca caataaaggt attcggcgca 1947601 ccccttttaa cggcttttgt atgatggatc atgtccgcaa ctgtcacacc gacagttgaa 1947661 tcaaggccga ggacgaccat tccaagtgaa tcaccgacta aaatcatgtc aactcccgct 1947721 tgttcagcaa gtttagctgc cggataatca taagcggtca gcatgacaat cggttcttca 1947781 gactccttca tttttagaaa atccagtttt gttttcatgt tttctcctcc tcatgtttag 1947841 aggagatgat ctgccgtttt cttctgcaag ccaaaaaacc ttccgttaca acgagaagga 1947901 ttcttcactt tctaaagttc ggcgagtttc atccctctgt cccagtcctt ttttggatca 1947961 aggcagactg ctgcaatgtc tatctatttt aataataggt gcagttcgca ggcgatactg 1948021 cccaatggaa gtataccaaa atcaacgggc ttgtaccaac acattagccc aattcgatat 1948081 cggcagaata gattttttta atgccttcgt tcgtttctaa aagcagaacg ccttcatcat 1948141 ctatacctaa cgccttaccg taaaaggttc cgtttaacgt tctggctctc atattagtgc 1948201 caataccgag cgcatagctt tcccataaaa gcttaatcgg cgtaaatccg tgcgtcatat 1948261 aatcccggta ccgtttctca aagcatagta aaatatgctg gatgacgccg gcccgatcaa 1948321 ttttttcccc agcagcttgg ctgaggcttg tcgcgatgtc cttcaattca tctggaaaat 1948381 cattaggctg ctggttaacg ttaatgccga tcccaatgat cactgaacgt acgcggtctt 1948441 cttcagcctg catttccgtt aggataccga ctgttttttt tccgttaatc aaaatatcat 1948501 ttggccattt aatatccgtt tggatgcctg ctgcctcttc tattccctgc acaacagcta 1948561 ctgcagcaag cagagtcagc tgcggtgttt tttggagcgg aatgtcaggc cgcaaaatca 1948621 ggctcatcca aacaccgttt ccttcttgag aatgccatac cctagacatt cggccccttc 1948681 cggctgtttg tttgtcagcc accacaaggg tgccttccgg tgcgttatta ttcgcgagct 1948741 catgagccgt tttttgcgtg cttgaaagaa cgtcatggta aataagatgc tggcccatca 1948801 cttccgtttt taatccaaaa cgaatttcgc tttcactgag ttttccgggt tttttgatga 1948861 gccgatatcc ttttcttcta acggcttcta cttcataacc ctctttccga agctcttcaa 1948921 tatgcttcca cacagcagtt cttgaacagc cgagagcatc actgattttt tggccggaaa 1948981 taaattcatt gccggcctga gaaaataatt caataaggtc ttttcttaat gttgaccgca 1949041 tgtcttcagc cactcctcta tgtgtttctt ttgattggag agcttccctg tcacaacagc 1949101 ctgctcgatc cactgtaatt cttctgacac ccattttccg gccggccggt ttcgaagcgc 1949161 aagcaagtcc ttacccgtga tatcaagatc cttaaggctt ttgatcggca ggttttgata 1949221 agcgtactga atgtccttca gtttcttttc atccagtttt tcgttttgcc gaagctgcga 1949281 tattttggcc gctgagagca gtgctttttt cccagctctg tacattgtca ttgcgtcaag 1949341 gctctggcca aacgtatcgg caatgtgaat ggcttccttg atcacttttc ccgggagctt 1949401 ccaggctttc aggaaaaggg gcgcgtcttt caaaactatg ccaaggttaa ttaaaagagc 1949461 agcccaaagc tcctcacggg atgttaaaga gaagaatgga aactcactcg ttgaaatcag 1949521 gttttctcgt ttatgataaa aaccaggaag ctcttcatac aatctcgttt gaatgagtgt 1949581 ttgaagcgcc tggcgagaag ctcttccctg cagcaatttc tcaaactcta tagtttttcg 1949641 ttcgactgaa acatgggaga ggagtgattt ttctttcgca atggcttctt ctgtttccgg 1949701 tgaaagcgta aagccaagct ggctcataaa gcgtacggct ctcagcatac gaagcgcatc 1949761 ctcttgaaat ctatcctcag gctttccaac ggttcgaatc actttctgat caatatcttt 1949821 cttgccgcca aaataatcaa gcaccttccc gtccgctgtc atggccatcg cattgatcgt 1949881 taaatctctg cgttttagat cctcttctaa tgatgagata aattgcactt ctgacggtct 1949941 tctgaaatca acataatcag attcagtccg gaatgtcgtg acttcatagg tttcatcctc 1950001 ccagagcaca ataatggtcc cgtgctcttt gcctacatca acagtccgct gaaacagccg 1950061 ttctacttga tcaggtgccg catctgtcgc gatatcgaca tctccgatcg ttcgtttcat 1950121 atagctgtca cgaactgcgc ccccgacaaa ataagcctga tggcccgctt cgattaagat 1950181 gcggagcacg ggaagtgctt tgataaaaac tttttccatg tgatcactcc ggttctgcta 1950241 aatcggcata aatctgttca tactggctga caattttttt agaagaaaat tcattttcaa 1950301 gcatctctat tgccgccttt gtaaaacgat tgcttagctg ttcatcttct aaaatgctca 1950361 tcgcgcgggc tgttgcggcc gtaacatcac cgacatccac caaaaatccg ctcacattgt 1950421 tttttataac ctcagggata ccgccaatgt ttgttccaat acaaggcact ccgcaagcca 1950481 tcgcttcaag caggacaagg ccaaagcttt ctttttcaga tagcagcagc ttcaaatcgc 1950541 taatagaata aagatcttca acacggtctt gatttccaag cattaagact tggtcttcca 1950601 agccatattt tctgataagc tcgcaggctg tcgatttctc cggaccgtct ccgactaaaa 1950661 gcagcttcgc tttcgttttg ccagcgatat tgcggaacac acggatgaca tcctgcacgc 1950721 gtttaacttt tctgaagttg gacacatgga tgacgacttt ttcatctggt aaaattccat 1950781 gtttctcttt aattgccgct gtgtttttct tcagatacac gcgctcgtct ataaagttat 1950841 aaatcgtttc aatttttttc tccggtttaa ttaaatcgta tgtttcagcc gcaagcgctg 1950901 aggagacggc cgtcaccctg tctgatgact caatagcaaa acggatcaga tcttttagag 1950961 acggatcata acctaacacc gtgatatccg tgccatgcaa agtggtaaca atgccgatat 1951021 tgcgtttcag catttgtttt gcaagatagg cgcaaacggc atgcgggaga gcatagtgag 1951081 catggataat gtctaaattc tcccgttccg ccacctcagc gattttgctt gccaatgtca 1951141 aatcatacgg aggatactta aaaacagcat attgattaac ctcaacttca tgaaaatgaa 1951201 tattgggatg atatgtattc agtctaaacg gaatgcttga tgtgatgaaa tggatttcat 1951261 gtcccttttc agcaagctgc ttccccagtt ctgtcgcaat gatacctgag cctccaacgc 1951321 tcggatagca tgtgattcct atttttagtt ttctcattgt tcgcccccaa gcacatcatg 1951381 atcaagcatc agcatccgtt tggaaaagaa accttcggca tactccacgc ccgcttcttt 1951441 accgtaaagc ttttctctcg cttcaacgat ttcaatatac ccattcgtca gaggagtaga 1951501 aacggaatcc tttgacggga taaactggct tttgtaggcg ttgaggcttt gtttctttgc 1951561 ctctattgta tccgagatat caataacaaa atccggctga tgaaaaccat ttatcatata 1951621 atagtaaacc ttgctgactt tatgcgccgg aaggcttttt tcgtctttat atttatggat 1951681 tccggcggaa aagatcgctt cttccaccag tgcagccgca ttgccgtgat ccggatggcg 1951741 atccttttta tacggcataa aaaccgcttt tggccgacag attctgatga cagtgacaat 1951801 tgaccgaatt gcctgatcac tcattattag gccgcggtct ggaagcgtta gctgaattct 1951861 tttatctgcg cctaatatgc gggctgcttc agctgcttct tctttacgca aactgaccgt 1951921 accgttagaa gagagttccg cttctgtcaa atcgcatatc attacttttt tttcctgttt 1951981 gacaaacttc gctattgtgc cgcccattcc gatctcgaca tcatcactgt gggcgccaaa 1952041 agcaagaacg tcagcattat acattcggct cttctccccg aagaaggtca cggaattcga 1952101 aaacaccttc atcaagtgtg cgcacaagaa tttccgcagt acccatattt gtggcgagcg 1952161 gaatggaata cacatcacat aaacggatta atgccgagac atccggttca tgcggctgcg 1952221 cggtcagcgg gtcgcgcaaa aaaatgacaa gatcgagtgc attggcagcg atcagtgcac 1952281 cgatttgctg gtctccccct aaagggccgg attgaaaacg ttcaatttga agacctgtcg 1952341 cctcatgaat tttcaaccct gtggttccgg ttgcgtatag atcatgattc tttaaaatat 1952401 cccgataggc agtcgtaaat tgaaccatat cctgtttttt cttgtcatgc gcgatcaaag 1952461 caattttcat tgtttatccc cccgtctaat caatgatatt ttctaaacca tacacaagct 1952521 gatcaatctt catgacttgt tcgactgaca gtttaacgcc tgacatgaaa gaagcacggt 1952581 tataagaatc atggcgtatc tgaagcgttt ggccatccat gccgaacatg acctcctgat 1952641 gcgcgatcag tcccggaaga cggacgctgt gcaagcgaat accgttttgc tccgctcctc 1952701 ttgctcctgg gagaatttct ttttcatccg gatgtccttg ctgcttttct ttacggactt 1952761 ctgaaatcat ttccgctgtt ttaagcgcag ttccgcttgg tgcgtcaagc ttctggtcat 1952821 gatgaagctc aataatctca acatcctcaa aatagttggc agccattttt gaaaatttca 1952881 tcatcagtat cgcaccgagc gcaaaatttg gcgcgatgat ggctccgatc cctttttctt 1952941 ctgttaaaga tgtgagctct tttaaatcag cttctgagaa accggttgtt ccgacaactg 1953001 gacggactcc gtgctctaat gcaatttttg tatgtacttt tccgatttcg ggcgttgtta 1953061 aatcaatcaa gacatccggt tgtgtttctg taaaacaggc atggatatct gtgtaaatga 1953121 aagcatctga ctcaacaggc atcacatcag ataatttttg ctgatcgtat gtatggtcta 1953181 tggcccctac aaggtcaaaa tgtggtgttc gttctgccaa tttaacagct tcctgcccca 1953241 ttcttccacg cggtcccgca atgactaatt taattgtttc gtttgacatc ttgatctcct 1953301 ctactttcct tcttcttttc tggtccagcg atctttatct cttgtattaa atttatgcat 1953361 gactcggtcg tgagcttcct ctaaagagat atcaagagag ttggctaaac aaaccaatac 1953421 aaatagcaca tcgcctattt cctcttccat gcttttatca tcttcagtcg ctttttttgg 1953481 tttttctcca taacggtgat tcacttctct ggcaagctcg cccagttctt cagtcagcct 1953541 cgccatcatg gccagcgggc taaaatatcc ttctttaaat tggcctatgt aacggtctac 1953601 ttcagcctgt atgtctttca ttgttttatc actcactgaa cgaaacctcc tatcatcctc 1953661 ttacatgtta gctaattcag atacgtttga caaatgttta agcacgtttg ctgttttctt 1953721 tttcatccac tataatataa acgctatcta atggaaggaa aaggggtttt gtgtgatgct 1953781 tggagaaatt agattaaaaa acatattttt tattttaatc ggagcggcaa ttttttcatt 1953841 tggcttggtt catttcaata tgcagaacaa tctggctgag ggcggtttta caggtattac 1953901 acttttgctt tatgcccttt tccacatcag cccctctata tcgaacctgg tgttgaacat 1953961 tccgattttt tttattggct ggcgtttgct cggcaggaca atgtttgttt atacccttgt 1954021 cggcactgta gccttgtctt tgttcctcag catctttcag cgatatgaaa tccatatgcc 1954081 ccttcagcac gacttagcgc tcgccgcttt atttgccggc gtattcatcg gagccggact 1954141 gggtattatt tttaagttcg gcggtacgac aggcggtgtt gatatcatcg cacgtttagt 1954201 gaataagtat tttgggattc cgatgggcag aacgatgttt gctttcgatg cctgcgtcat 1954261 cattttgtct ttgcttactt atctctccta taaagaagcg atgtatacgc tggtagctgt 1954321 atttgtagcg gcaagattaa tcgattttat tcaggaaggc ggatacgctg ctaaaggcgc 1954381 tacgatcatc tcttcgaaaa acgacctgat tcagaaaaag attcttgaag aaatggaacg 1954441 gggcgtcacc attttgaaag gacaaggttc ctacacaaaa gaggatatag atgtacttta 1954501 ttgtgtggtg ccgaaaaatg aattggtgat gctgaaaagc gtgattaact ccattgatcc 1954561 ccatgccttt gtagcggtaa gcgatgttca cgatgtgctc ggagaaggat ttacgcttga 1954621 tgaaaataaa aatccgcttc cgcgctgaca tgtaatagaa aaaaggcggc tgaccgccgc 1954681 ccctcatcct tatttagggt agtccctttt tttcagcttg tttttttccg ccttgtactt 1954741 tctgtaaccg acataggtaa gagcagtaat gatgatactg ccggttgtaa tgatcaccca 1954801 gagtaaagac ggatcggcat catcctcctc caccctgtca aacacatttt tcaggtcatg 1954861 ctgaagaagg gaaagccgtt caagcttcgt gctctctgtc atttgctgaa attcctcttg 1954921 ctcaataaca tctatatgtt ttccgactgt ttcaagctga tcctctgata catcgattgt 1954981 aagactgggg taaatcaagt catataaact gataaattca ttccattttt catgaaagct 1955041 tgtgcttcca ttcttttgga catctcgctt cagttcagta aaagcttcca taatcggttt 1955101 ttccagtgag ccccaaagcg ggtcagaccg attgtcaacc gcatccatca gcattctgaa 1955161 ctgcgcggct gctctgagtt tttgtgtgtc tgatgtatca gcttgcttta aactccgaac 1955221 catatcatta tagcccaatg tgatttgacg aatttgggct cccgttagca tggggtcttg 1955281 ctgttttttc tcagcggatt ttaatgtttt ttcaaaatac tccaagactt gaagcgcctc 1955341 ttcatatttc gcctgtcggg tcatttgaaa gactgtatcg gataaatcat tcaattcctc 1955401 gaggcttccc cgctctgcag ccttggcatt tccattataa aaaataagtg caatcaacaa 1955461 acagatcgtc agctttcgtt tcatgcaggt ccctcccact ctctctcctt acagaatatg 1955521 aagaaaggga caaggataga ccaacattgt ctttacatca gctcaagctt cgtttgcttt 1955581 tttgagacca caagaaagta agcaagcgcg attgaaaaga tacttagcca aaatgttccg 1955641 tatcctattt cagtcatata atcagaaagc atagagtatt gcggcatcat atcaaacaag 1955701 tagtcaatga catcgttatg cagtgtccag actgcagcaa ttgcaagatg ccaaaatgaa 1955761 aaacgaaaat acggactgta taatacgcct tgaactgcca ttgcaaaatg cgaagcaatt 1955821 agcatgtagc cctcccacgg caagtcacca gttactgcaa gcacaagaaa attcatagcc 1955881 accgcccata ggccatactt tacgagggta actagcgcaa gcgcctctaa aagcggagca 1955941 ttccgtttca tgagaaaggc aagcagcaca aacagaaaga aaaacgttgc tgtcggactg 1956001 tccggaacaa aaatcaggaa acgggccggt gtctccaaaa gctgcggcaa gtaccaatag 1956061 tagccgtaaa ccgttcccag aaaattaatg gctaagacaa gaataagcat cggccgctgc 1956121 cctaatacat attgaaacca tttcacatcg aatcaactct cagtctgtaa aaataatatg 1956181 tccatataaa aaagctgacg ccgggtcagc ttttgataat aaaagtatat ccttccattt 1956241 gacaattcac aatacgttat tttgcggttg tttcagaaat aaattttgca agttcttcga 1956301 gctgcttatc atttcctttg aacacacccg ccggcatttt gcctttccct tctacagcga 1956361 tttttttgat ttcatccggt ttcagcccgc tgtcaaccaa tgaaggcccg gccgctcctc 1956421 cctgaaggtt atccccatgg caagaaatac agccctgttc cttaaaaacc ttatatcctt 1956481 ctgcattggt gtcaatgtcg gcttcttttg taattttccc ctgttcttct gccttggccc 1956541 agtcatgagt agcaactgac tgccacgtca aaaatacagc agcggaaatg gccagaagca 1956601 tcataccgac agcgaccgga cgcttccacg gccttctttc tgtccctctg tctaggaatg 1956661 gagccaaaag cagggcccca aaagcgagac ctggcataat catggcgccg accactgtaa 1956721 agcttccggc ggcgtattca tacttcaaca gctggtataa gaaaagaaaa taccaatccg 1956781 gcagcggaat ataaccagta tcagtcgggt ccgccatccg ctctaaaggc ggctgatgca 1956841 caatcgtcaa aacgagaaaa ccgatgagaa agacagctcc aaccatccat tcctttaaca 1956901 agaaatttgg ccagaaagcc tctgttttac ccggatactc cgaataatcc ttcggtatat 1956961 tcggcttttt ttcagccggt atccttgagt cgcctacaaa tttcatccct ttgccccggt 1957021 gcatgtcatc ccctcccttt tattcgcaga tcaagagttt aaagcggtcc tgaaatcccc 1957081 tgcttccgga tcataataaa atgtgcagcc atcagcccga acaatgcggc aggaagaaaa 1957141 aatacatgga tcgcaaaaaa cctagtcagc gtttgggcgc ctacaatatc cggatgccct 1957201 gcaaggagcg ttttaacttg cgttccgatc aaaggcgtgg cttcggcgat ctgcagtccg 1957261 acttttgttg caaacagagc cttcatatcc caaggaagca agtagcctgt aaagccaaga 1957321 ccgagcataa caaaaaagat cagcacaccg acaatccagt tcagctcgcg cggtttttta 1957381 tacgcgcctt ggaaaaagac cctcagcgta tgtaaaaaca tcatcacaat gaccaggctc 1957441 gcaccccagt ggtgcatccc cctgacaatc tggccgaatg ccacttcatt ttgcaaataa 1957501 tataccgatt cccaggcatt tttgatatca ggcacataat acatcgttaa aaacattcca 1957561 gataatactt ggataacggt tacaaaaaac gtcagtcccc caaagcaata cacaaacgca 1957621 gagaaatgat gggcgggatt cacatgttcc ggtacttcgt gatcggcaat atccctccac 1957681 atcggtgtaa tatcaagccg ctcgtctacc cagtcataaa ttttgttcag catgtcaccc 1957741 ttccccctta ggctttgctt ttccaagata caggaagccg tcttttactt cttgctcata 1957801 atgatcaaga ggcgcaagcg gcggcgtgcc agggacattg gtgccgtcct tttcatagag 1957861 tccgtaatgg catggacaaa agaatttatt cgggttttta ggatcactat tccagttcac 1957921 cgtacaccct aaatgcttac aaattggcga aagtgctaca atttcatccc cgtttttgaa 1957981 gacccaggct gatcttgact cttctgactc ataccaggca tcgacttgat taattttaaa 1958041 atcaaagcgc tgcggctctt ttgtcaactc atcaacgctg acaacctgaa ccatatcctg 1958101 cttccctgtc gattttaata ccgggtcgag tgcgaagcga accataggca tgagcatact 1958161 agccgccata aaacctccta cgcctgtgag cgtataattc aaaaattgac gtctggatat 1958221 atcatgtttt ccgcccatct cttctccccc ctctaagtca cccctgcaaa ctgactaaaa 1958281 tagaaaatat tgcaataact ctagacaccc tcataatata tgaatctctc agcaaggtca 1958341 atatagccaa aatattgttt ataaggaaat gtaagtgttt ttataaagtg ctccataact 1958401 gtaacaaaac gttcaaaatt tcagcagtgc gttcatccaa tatttttctt tttaaagagt 1958461 catttaaatg ctctaatgga acagacgatg taacaatcat tttgcctaac gcatcctcag 1958521 ctctccaact ttcgtcagat gtgagcagga caacatgcgg aaattccgtt atcagctctt 1958581 cccgcaaatc cttaagccct tgaacggtta tttcatttct atcaacatat gtataaggcg 1958641 gaagtaaata tacccgtccc tttaactgcc tttcaagttc ttctgagaga agctgcgtaa 1958701 actcgccttt ctccgccgcc attttaaaat ggttattaac ccttatgtta attaatggta 1958761 tgacagcggt atcaatgtaa tccttagctt gtaaatagtc cttggcatca gtgattctcc 1958821 acctcatcgt tctccccctt tacggcaaca agccttgcaa ttcactgcaa ggctggtcat 1958881 attatgtgag ctgatttaat tggcgcgata attgttcaaa tgcctcttta tcatgacgat 1958941 ctaacgcgtc gtcaatgtct tttaataatt tttctctttg gaatgtggaa atagcgtgct 1959001 ctaaaatctg ttccgccaat ccctgatctt ttttattctc aaaaaggttt ttcggaatat 1959061 gcgggttgga ctccagcacc gccgcatatt caggtgagct gtaagccgaa cggaaattaa 1959121 gctggataaa caaatcctgc tgtttattta atctaatatc atgaaaagat ttttccgcgt 1959181 cggtagtcat gacattctct ttatagaacc ggaacggaac ttcttcaaca caatgtgttg 1959241 acattataat gcctctcggg caaaattcag cctgctccac aaaatgaacc ttctccatga 1959301 gagaatcatg gctcattaag tagttcaaga tccaaacgca ctctcggcgc tttaactgat 1959361 aatggtttaa aaaccaacgg ataaaatctt ttttctcatt gacagaaaca ggggtctgca 1959421 tgtaattccc tcctctatcg ttcgtataat ctatatactt atatgttcca catgaatggt 1959481 taatattcct gcttatctag aaaattcatc ctcgattcgc aaaatcgttt cttcaagctc 1959541 ttcattggct ccgtccattt caagaacctt tttcaaaagc ggcagcgctt ctttttgaag 1959601 accttcttct aataggaagc ttgcgtattc atataagaaa tctctatcct cccggtaatg 1959661 aagataggca gcctcaaagg attgttttgc ttcctcgtat tgctctaatt cagtatatgc 1959721 gcttgcaaga taccaattgt atttaggatc ttcttcaccg tagcttcgaa cctcttgaat 1959781 aagatcaatg atctgatcat aatcctcttc tttgtgatac acggcaagaa gtgtatgaag 1959841 cgcctcgaca aagcccggat caagcgcaag cgcctcctga agcagcttct tcccctcttc 1959901 tgacttcccg attttcaagg ccattttggc ggcataaagg aaaagttctt tgttatattc 1959961 atcatatctg atcccctctt ttgccgtttt taatgcctct tcatacattc cttcagcttc 1960021 atagcttttc gagagcggca tataaagtga agtataagat ggatcaagct cctttaaatc 1960081 agacagctgc ttaatagctg ttttcacaag ccccgcctgt aaggctgtaa aaccatagcc 1960141 gaaaatcgta ttaggatcag gattctcatc gacagctttc tcataccatg gaatggcatc 1960201 ctcaaattca cctgaggcac ttaacgattc tgccagtctt tgatggacat taacgccccc 1960261 gatctcactc tgctcctcag ccgttgtttt aaaatattga accgcttttg cataggctcc 1960321 ctgagcaaag taaagttctc ccagtgcaaa atcaataaca ggttcattgt ccagaatgga 1960381 ctttgcctgg aaaagctttt gttcactgac ttcgaataac ccctgcatct gataaagatc 1960441 cgccataagc agcaaacttt ccggatatga tggatctgtt tccggaatag tctccagcac 1960501 agcgagggct ttttcttctt cgtcaatatc tattaaaagt tcagcgtaga aattcgtcag 1960561 ttctgtttca tttggatata aatcatgtag atcactaatc agtgaaatgg ctttttctac 1960621 atcgccccac tcgtaataaa gctgggctgc aatggcttta tcttcatcat gcagctgttt 1960681 ttcagccttc gagagcgtgt tgaggccttt ttctgtttca cctgcttcaa ctaattttat 1960741 ggcttcttga atcaatgtat tcaaatcgga ccggtccttt cttttcctat acaacatcaa 1960801 ccatacaaaa aaagctttat ttgttcgggt taatcttatc ataattcaga cgaatgcccc 1960861 cggcaaataa gatgcttctg tacggaaggg aattattgag tcttattagt ttaccaaaag 1960921 atcttgagat agaaaatgaa aaaaggaaga tcgccctctg tacagtaaag cagctctttg 1960981 acctgccggc ttgtaagtaa agcacatccc cccttttcgt ttttctatcc gttctataag 1961041 acaagctatg ttttttcgcc tcgaattatg atctgcataa aaaatcctga agtaaaactt 1961101 caggattttt tcgaaagctt atttaaatgc tcgaagaagg ttggataaga aacgtgaatg 1961161 gcatccgtgt gctcgatttc aatcggctcc tccgttatac aggaagcaat accaagcatc 1961221 attccgattc gatgatctcc gtggctggac actgcagcgc cgcctttcaa cgtttgtttg 1961281 ccataaacct tcattccatc tgctgtcggt tcaatttcag cacccagctt gcgaagctca 1961341 gaaacaacag tatcaatacg gtttgtttct ttcactttta gctctgccgc gtccttaata 1961401 acggtggttc cttccgcctg agtcgcaaga agcgcgatga tagggatctc atcaattaaa 1961461 cgcggaatga tatctcctcc gatttcaact gcctttagag atgacgtttc tataatcaaa 1961521 tctccataag gctctgcacc gctatcagca gatggtttga tttcaagttt tgcccccatg 1961581 ttttgaagga catcaataat acctgtccga gtcggattta aacctacgtt tttcaataca 1961641 attctgctgt ttggaaccat cgcgccagca gcaaggaaaa acgcggctga agaaatgtct 1961701 ccaggaacaa aaatatcagc agctgtcagt ttctggccac cagcaatgga aacactcgtt 1961761 tgatcttcag aaagcttaac gccaaaagca gaaagcatcc gctcagtgtg gtcccgagat 1961821 ttatggggct ctgttacagt tgttgtgccc tcagcctgta atccggccag caaaacagca 1961881 gatttaattt gcgcgcttgc aacaggtgat acataatcaa ttccttttaa tgaagcgccg 1961941 ctcactgaca gcggtgtaaa ctctccgccg gctctgccgt cgattttagc ccccattttt 1962001 ttcaaaggct cagtcacacg cttcattggg cgtttcgcaa tgctctcatc tccggctacc 1962061 gcgctgtaaa aaggacggcc cgccaatatt ccgagcatca ggcgaatcgt tgtacctgaa 1962121 tttccgacat ctaaaaggct ttctggctct ttcagggcat cgattccttt tccgtgaatc 1962181 acgacatcgc tgctgctttg ctcaatgtga acacccattt ttctaaagca atcgatcgtg 1962241 ctcagacaat ctgctcccgg cagaaagttt ttaactgttg ttgtgcctgc cgctagcgcg 1962301 ccaaacataa cagagcggtg agaaatggat ttatcaccgg gaatatgtat ttctccatgt 1962361 aaggtctgca ccttatctcg tttcattttt tccacctcaa tcagcataaa aagtttcata 1962421 ttccgcccgg gcttcaatgc attgttctgc ccttttgcgg tcgtcatcag actgaaaact 1962481 gatccttaaa atcccgttaa tatcctctcg tgtttcgata atgcggatat tcgtgatact 1962541 gatgcgctcc gcagctaaga tcgctgttat ctcggatatt acacccggat gatcgggtac 1962601 atccacatat aaatcataaa atgcaggtat cgctcccttc tgccgaagcg gcagcccgtc 1962661 gcgataatcc ttggctgttt taaaataacg aaatagattt tccgcatctt cttgttctac 1962721 atatgtacgg atcttgtcaa tttcacgaat ccactcatca aaacggtcta agattttatc 1962781 tttattatgt aataaaatat cccgccacat tgccgggctg cttgatgcaa tccttgtaat 1962841 atctctgaac ccgccggcag caaaacgctt aacaagcgga tacaggtttt ccgaatgatg 1962901 ggtttggtga acaaggctag ctgctacaat atgcggaaaa tgactgatta cgcttgtaac 1962961 gccatcatgc tcctctggcg acatttccac aaaatgggca ttcgtcccct tcagcaggtt 1963021 ttttaactgt tccacagctt gtttgtccgt tttctggcct ggcgttaaaa tataaaatgc 1963081 attttcaaac aggaactcct tcgcagcggc cactcctgat ttatgtgaac ccgccatcgg 1963141 atgccctccg acaaattgat agcggctagg cagcacttga tcagcgtaat caaccacttt 1963201 ttgctttgtg cttcctacat ccgtaatcaa aagctcatgt tcaattcctg aatgagccag 1963261 ctcttcaagc ataaccagtg tttgttcaac aggtgtcgca atgattactg tagctgcctc 1963321 tttcacaccg ctaataaacg aatcagcacg atcgtctatc acgcctaatt ttaatgccgc 1963381 taccgcctgt tcatcagaga tgtcgattcc gataatccgt ttgccgggat gatttttttt 1963441 gatggctagg gcaatcgaac cgcctatcaa tccgagaccg gcgagcaata ttgtatcttt 1963501 catttgattc atacgtcatc acctggttta tagactaaag aggtgatatt tgatcacctc 1963561 ttataaaatt tcagctaaaa tggcaagtat ttcttcattt tgctcttttg ttccgatcgt 1963621 aatccggagt gatgtcggga aacctaatgc gtttcctgac cggacgatat agcctttttc 1963681 cagcagagcc tgaaacagtt catcagcagg acgtttaaag tcaattaaca caaaatttgt 1963741 ctgtgaaggg tagcacttta aaccatgagt tttcgcaaaa tcataatact gctgaaggcc 1963801 tgcattattt tgctcgacac aggaagcaat aaacgcttga tcatcaagtg ctgcaatcgc 1963861 cgcagcctgg cccagacggc tggtattaaa cggctctctc gccggctcaa tctggcgaat 1963921 caggttctcg tcagcaattc cgtatccgac tctgagcgct gccagaccgt atgcctttga 1963981 aaatgtgcgc aaaatcatca aattggaata cttgcttaag agcggcacgg tttccgggta 1964041 atcctctgct gttacatatt cataatatgc ttcgtcaaga acgacaagga cacgagaagg 1964101 aacgcgctcc agaaatgcga gtaattctcc ttcagatgta taagtgccag tcggattatt 1964161 cgggctgcat atccaaacga cttgtgtctg ttcgtcgatg gcttctaaca tggcgtctaa 1964221 atcatgtgag ccgtcgggac gaagtgcaat ttcacgtact tcagcacctt caataaccgc 1964281 attatgttta tattgcggaa aagtgggggc agcagtaacc gtgtttgttt tatcgtttaa 1964341 aaatgcccgg cagatgatct gtatgatttc atcagaaccg ttgccgaaaa taagtgatgt 1964401 ttcgctgaca ttgaggtgct tactgagcct tgtccgcaaa gcggcgctat acccgtccgg 1964461 gtaaagggct agctgttgaa tctcatgatg aagcgcctct tttgcagcct ctgaacagcc 1964521 gtaaggattc tcgtttgaag caagcttcac aactttatcc aagccatatt ctgatttcac 1964581 tgcttcaatc ggctttccag gctgataagg cttcagctgt tttaaatgtt ctttgatacg 1964641 caaatcagtc acctcatttt aaactgtaca agccgctaaa cgccattgca taatcctcaa 1964701 actcctgcag cgcctgattt ctcgtttcag cgctgatgag ccggtccttt aattcttcta 1964761 tttttctgac gagcgcactt cccactacga caccgtcact aatttcattc atctttatga 1964821 cctgttcacg gtttgatata ccgaacccta cagcaaccgg aacagtgctg agattcttca 1964881 cagtacgaat gaacgggtac acggatgaat tgaactcatt gcggacaccg gtcacaccca 1964941 gagaagatac acagtagacg aacccctcgg cttgttcaat aatggttttc aaacggcttt 1965001 cgcttgtcgg cgcaactaaa gaaatatacg tcacctcatg gcttttacat tcctcttgaa 1965061 ggctgttgct ttcttctaat ggcagatccg gaacaagcag accgtcaata tgattttccc 1965121 gcagtaaagc gaaaaagtat tctttgttca attgtaacac aggattataa tacgtaaaga 1965181 ggataatcgg aatattcact ccgttttttt tcatttctcc gcctaattcg attgccttta 1965241 cgatattcat tccttgatca agcgcccgct ttgaagcccg ctggatcacc ggaccgtctg 1965301 caagcgggtc agagtatgca acaccaagct ccaatgctgt ggcgcctgct ttttggagtg 1965361 acttcgccag ttcaatcgaa acctcaggaa ctggatcgcc cgccgtaata aacgggataa 1965421 acaatttttc tgatggttga agatccaatt taaacatggg ctttcacctc ttcttccaat 1965481 acattcatta atgtgttgac atccttgtct ccccggcctg ataaacagac gagaatgagt 1965541 tgaccgcgat ccattccttt ggcgagtttg aatgctttcg ctaacgcatg ggcagattcg 1965601 attgccggca aaatcccctc tttttctgac aaaagcttta atgcatccac cgcttcttca 1965661 tcggttatac tgtcataagt gacacggccg cttttatgca aatatgcatg ctccggaccg 1965721 attccaggat agtcgagacc ggctgaaata gagtagggct caataatttg cccgaactca 1965781 tcctgaatga gataagtcaa tgaaccgtga ataaccccta cggttccttt cgaaatagtg 1965841 gcggcatgaa gaggtgtatc aattcctttt cctgctgctt cagcgccgat cagttcaaca 1965901 tcttcattta aaaatgcctg aaacataccc atcgcattgc ttcctccgcc tacacatgcc 1965961 actactttat caggcatagt gccttcaata cgtttcaact gatccttcgc ttcctctccg 1966021 atcatttttt gaaattcacg gaccacttgc ggataaggat gcgggccgac aactgatcca 1966081 atcatataaa agtgatcctc acaatgctga acccagtacc ggatcgcctc atttgtggca 1966141 tccttcaatg ttccgtttcc gcttgttaca ggcactacct ccgctccaag aagcttcatg 1966201 cggaaaacgt tcagagactg gcgggcaaca tcctcttcac ccataaacac agtacaggaa 1966261 aagccgaatt tggctgcaac tgttgcagcg gcaacaccat gctggccggc accggtttca 1966321 gcaatgattt tcgttttgcc cattttttta gcaagcagcg cttgacctag cgcattattg 1966381 attttatgag aacctgtatg gtttaaatct tctcgtttca aatagatttt cgcgccgcct 1966441 aagtattcag tgactcgatc agcgtatgtt aatgcagtcg ggcgtccgga atagtccttt 1966501 aacagcttat aatactcttc acgaaaagcg ggatcatcct tgatttgttt aaatgctgtt 1966561 tgtatttcat ctaacggctg catgagtgtt tccggaacaa actttccgcc aaaatcaccg 1966621 tatctgccta tttcattcgg atatggatac atatcggttc atcctttctt ctaaaagcct 1966681 catcagattc tgatcttttt gtccgttttt ttcaattccg ctggcaaggt caattccttc 1966741 tggctgccat ttcaataggc gtgtgatgct atccggattc acgccgccag cgataaagca 1966801 gcgtttacca atagccgcct gctgatattc cggcacacat tcccaagaaa atgcaacacc 1966861 agttccgcct ctagaccctt ttacagatga atcaatcaca aagccgtcaa cattatcttt 1966921 aaagcgggct atttcttgag ttgtgttatc ttgatggtga agcgccttcc atatttcaca 1966981 gcctgtcagc ttgcgaagag cagcagcatc cgccggtttt tcatcaccgt gaagctgaat 1967041 gacgtcgagc ttcaagctct tggcaatacg tgacatcgtc tctattgatt cattaacaaa 1967101 aacacctgca acctgttttt cgacacgaac ttggttcagc cattttttca catcttccgg 1967161 agatactttt cgtttgcttt cagcaaaaat aaatcctagg taatcagcct gtgattccgc 1967221 cgcaagctgc aaatccttta gtgaccgaat accgcaatat tttaatgccg gtttcttcac 1967281 aacctcactc cctaaacaaa gcatggattg ctttacgctg agaagtttgt ctcatcaatg 1967341 attcaccgat aagtacagct cgtgctccat gttctttgac aaatgttaaa tgttctaaag 1967401 aaccgattcc gctttcgctg acaagcagtg attctttcgg agcaagagat gcgatttgtt 1967461 ctgtctgcat gatagaggtt tcaaaagttt ttaggtttcg gttgtttatg ccgagaatat 1967521 caggcgtgaa tactttcaat atttgttcta gcgttgttgc atcatgaacc tccactaaca 1967581 cgtccatctc cttttcacct gcttcaagat ataattcatg aaggtgtaag ggatcaagca 1967641 cttcgccgat taacaatatg gcatccgctc cgattcttct tgattcctcc acttgaagag 1967701 aatcaataat aaaatctttt ctgagtacag gtatcgaaac agcgcgcttt acgtctgata 1967761 aatagctgtt ttccccttga aaaaacgggg tgtctgttaa aacggaaagc gcatctgctt 1967821 tcgcagtttc atagtctttt gcaatccgca caggtacaaa attctcttta ataagccctt 1967881 ttgacggcga cgctttcttc acttcagcaa tcaacccgat aaaccgattc aggcttgcca 1967941 gcgcctcttt aaatgaacgt ttttcgaaag gctgctctac cggcagaacc agtgttttca 1968001 cttcttcttt cttttgtttg atgatttttt caagcataga tctcttcctc tttctgcttt 1968061 agtcgttcaa gctgcgcggc agcgcctccg cttgtaatcg tctctaacgc cagctccgtt 1968121 ccttccttca gtgaggcggt aattcccgcc gtgtaaatcg cagcacccgc attaaaagcc 1968181 gtaatagata aagcggaact gctgctttta ttttcaaaaa tattctgaat gagataagcg 1968241 ctctctttcg gagactgcac ctgtaaatct tcaagtctgc catttgtgaa accgaaatct 1968301 tcgggtgaaa cggtatactc ccggcgctct ccgtccttta attcaatcac gtcggtcggt 1968361 gctgtaattg aaagctcatc taaaccgtca cggcttgata caaacataac gtgcttcggc 1968421 tgaaacgtct ccagtgcgct tgccatcagt ccagcttttt caacagaata gaccccaatc 1968481 acctgacgct tcgcctgtaa aggattgctg agcggcccaa gcagattaaa taccgttctg 1968541 aaacctagct cttttctagt acctgctaca tgtttcatag acgaatggta aagcggcgca 1968601 aaaagaaatc ccatgttgtt tgtttcaatg ctgcttttga ccttttcggg agtggtttga 1968661 atagaaacct ctagctcctc taaaacatca gcgcttccgc ttttagaaga gacagagcga 1968721 ttgccatgct tagcgatttt cgcaccagct gccgaggcaa caattgccga ggccgttgag 1968781 atattaaaag tggaaatacc gtctccccct gttccgcatg tatcaacaat atcaggaagt 1968841 ccatcgactg taagagcgtg tgcccgcatt gccttcacaa aacccgcaag ctcttctggc 1968901 gtctcccccc gatgagcaag aattgacaat atccccccca tttcagaagg agtcatttcc 1968961 gctgccatca tcatattcat cagcgtttca gcctcaccgg cagtaagggt ttttccgtca 1969021 acgcacaatt gtagaaatct gttcatcagc tttatcctcc ttgctatgaa acatgtcttc 1969081 tgcaatatga atcgttttca gcagcgcacc ggctttatta cagctttctt cgtattcggc 1969141 ttccggaaca gaatcagcaa caatgccagc acctgcctgt atcgatgcaa caccgttctt 1969201 tacactcatc gtgcgaatcg taatacaaga gtcgatattc ccgtcaaacc caatgtaggc 1969261 aatacaccct ccgtatgtct ctctcggtgt tggctcgagt tcttgcaaaa gctgcatggc 1969321 acggattttg ggtgcgcctg ttaaagtccc cgccgggaaa gcagacatca gtgcatcgac 1969381 aggatgaacc ccttttttca atcggcctgt aaccaccgag ataatgtgca tgacatgtga 1969441 aaaggaaaca atttttgtga actccggcac agaaacagaa ccatactctg ctactctgcc 1969501 gatatcgttt cgggcaagat caacgagcat gtaatgctcc gctttttctt tttcatcctt 1969561 catgagctca accttcagtc tctcatcttc agctttgtct gcaccgcgtt ttctcgtacc 1969621 ggcaatcgga tggatttcta agtgcccgtc ttgaacgtgt attaaccgtt ccggagagct 1969681 gccgactatt tctctgtcta gcagtttcat ataatacata tacggcgaag gattgacgat 1969741 cctaagcact cggtataact caaaagcatc tgcttttatc ggcacctcaa atttttgtga 1969801 taaaacaccc tggaagatat cgcctgcttt tatatagctt ttgatttttt ctacatcagc 1969861 cataaaagcc gatttttcat aattagaaga tactgtctca aagctgggtg tcttgtatga 1969921 atcagcagaa agaaacagct cttttatgtt tttttggtcc atcatttttt caatgagatt 1969981 ttgaagctcc agatgatttt gatggaatac atccattttt tcgttttttg tttcctctcc 1970041 agtgagcctt gcatattgga taaagtggac gtttttggtt tcatgatcat acgcaattaa 1970101 tgtccggcaa acaaacagca tacacttttc catgtctgtt tctttggtat gcgaaggaac 1970161 agaaggctca atcagcggga tcatatcata gcttaagtac ccgacagctc cgccgacaaa 1970221 aggaatgcca agctcaggtg ttttgatttt gtatgtggta ttcatccagt tcagcacttc 1970281 ttttagttca tttcctgtgt aaagagattt gctgtcctga tcagcggccg aaaaacggcc 1970341 ctgctcttct ttaattgtga gaaatggatt caggccgata aacgaatatc tggaccaagt 1970401 ggatgtatcg tccttgcttt caagaagata cgtaatctcc ctgtcaagct tctctatcat 1970461 ttgaatgggt gtcagtgtat cgactgtgaa ggtctccaca atcggtatcg tgtggtggga 1970521 caagctgtcc tctaaaaatg cggaaatgtt tgattggaaa ttcattgctc tcactcctta 1970581 tggcaaggag aatgagaaga tggcatgaga ggataaaata ctatataaca aataaaccca 1970641 aaagaaagac ttcttttggg tagaataaac ataatgtctc agctcaacta aactcattct 1970701 ctgctaccct attctctaac tcaactcatt ctaattgctt tatacacact cttgtgtatt 1970761 tctaagctgt tcttatcgta ttacaattca gtattttttg tcaatgataa atcgggcctc 1970821 aatacgacaa ctttttctaa atatacatgt ctgatctgat cctgagggac atctgtctgg 1970881 accgtcatca tgactcttat gcactttttc agaccgcctg ttacgtccat ttcctgcata 1970941 catgttaccg gtacatactg ccatcctgaa agctcgcgaa cagcttttgc cgggaaaaca 1971001 gcgtgcaaat caggtgtagc cgacagaagc atttgaacaa catcttccgg ttttgtatga 1971061 ttttcttcta tgattttctc taacagctgt ttagtttttt gtaaaatttc ttcttcagta 1971121 tcccgttcaa ctgtagttgc tccgcgaatt ccgcgaatca tcatgatgtc tcctccaatc 1971181 gccatttgtt cagccagctc tcaagttcat ttctggaaaa tgtatgatca gcaactttcc 1971241 ctaattcgtt gagcacaata aactgaatct tcccgccacg ggttttctta tcattcatca 1971301 tacggttcaa gagaaccgaa gtttccgtct cttttctgat ttgacttgga taacccaggc 1971361 tttttagcca gctgaccaaa cgttttctgt ccatttcaca gcctacagtc ttttcgctta 1971421 tatataaagc aaactgcatt ccgagggcta cggcatcacc gtgagtgatc tgcccatatc 1971481 catattccgc ctcaacggca tggccgagcg tatgcccaaa gtttaagtaa gctcttatcc 1971541 cctcttcttt ttcatcctgc tgaacgacag acgctttaat tgaaatgcct ttaaaaatca 1971601 tgtcattcag ctgatcatta gtgatatcac gcagtgagtg gatattcagc agctcctcca 1971661 gaaacgctct gtcatagata aaagcgtgtt taatcacttc tgccattccg gacctaagct 1971721 ctttttcagg cagagaacgc aggaaatctg tatcatagag cacggctttc ggctgataaa 1971781 acgcaccgat tagatttttt ccaagcggat ggttcacggc tacttttcct ccgactgcgc 1971841 tgtcatgcgc caagagcgtc gtaggcattt ggatgaaatc aatgccgcgc ataaaagtgg 1971901 cagccacaaa accggcaaga tcccctacaa caccgccacc gaatgcgatg atgcatgagg 1971961 agcgatccat atgaaaacga atcgcttcac tctgcaattt tgtgtacatg tccatggatt 1972021 ttgcctgctc tccactcggt accgtcactt ttttcacagg ccatttttct tgcagcaaat 1972081 ggagcatttc atcaccatac aggcggtcca cttcttcatc cgtgacaaac ataatccttg 1972141 ttaaaggcct gtttaaagag gttaatagtt cgcaagcctt ttttctgata ccttgtccga 1972201 taaaaacagg atatgacgag gaagcagttt gaacatgcag tgtcttcatt aaaattccct 1972261 cgacagtttt ctcatattct ccacattttc tctaatgcgg tcaatttgat ctaatccgaa 1972321 ttgttcaacg actgcgttcg caatttccca agcgacagcc gcttcagcga ctacacttgc 1972381 cgcaggaaca gcacagctgt ctgaacgttc aatgctggca gaaaacggtt ctttcgtttc 1972441 aatatcgaca cttttcagcg gtttatacaa agtcggaatc ggcttcatga ctccgcggac 1972501 aacaatcggc atccctgtcg tcatgccgcc ttccagtccg ccaagtctgt tagtagcacg 1972561 ggtgtatcct ttttcctcgt cccaaatgat ctcgtcatgg acttcgcttc catttcgccc 1972621 tgctgcctca aatccgatgc cgaattccac acctttaaat gcgttaattg acagaacagc 1972681 ggcagcaagc ttgctatcca gcttgcggtc ataatggaca tagctgccca cgcctaccgg 1972741 cattccctcg acaatgactt ctactattcc gccgatggaa tctccgtttg cctttgcttc 1972801 atcaatggca gccatcattt ttttgcctgc ctcttcatcg tagcatctga caggagactc 1972861 ttccgttaca cgctgcaagt cttcaattga cgtatactct gttttttcag ctttaacagc 1972921 gccaatttgc aacacgtggc ccgccacctt aatgccaagc tcagaaagaa tctttttagc 1972981 tacagcccct gccgccactc tgacagttgt ttcccttgct gaagaacgct caagcacatt 1973041 tctcatatca cgatgattat atttaattgc accgtttaag tcagcgtgcc caggtctcgg 1973101 tctggaaatc tggcgcttca tttccttttc ttcatcttct gtaatcggag cggcgcccat 1973161 gatttttgtc caatgcttcc aatcgttatt ttcaactacg agagcaattg gcgaaccgag 1973221 tgtacgtgca tggcgcaccc cgctcataat tttggcctgg tctttttcga tctgcatgcg 1973281 gcggccgcgg ccgtgtcctt tttggcgtct ggcaagctca aaattgatat cttcctccgt 1973341 tatgtaaagc ccggcaggta caccctcaat aatggttgtc agttgggggc cgtgtgattc 1973401 tccggctgtt aaatatctca tgacttcttc tcccttcatc gcattaacgc ttttaagtaa 1973461 gactactata acatattttt cagcaaaaag tcagtctatc ttttttgata aaagaatgta 1973521 tcggctggga ctaggccaaa tttctcggga ttgaagattt gctcggtgct gccgacaaaa 1973581 agaactccat tcttcttcaa gctatgtgcc atttttaaat acagctcttc cttcgcgctt 1973641 tctgtaaaat aaataaatac attgcggcac acgattaagt caaagtcttg ttcataacga 1973701 tccgccagca aattgtgctt tttgaatgta atattctttt tgatttccgt tttcacttca 1973761 taacttctat ttgcgttttg cgtaaaataa cgatctttca cagatagcgg cacttcctgt 1973821 aaagaccgct cctgataaac gccttttttc gctttttcca atgctttttc atcaatatcc 1973881 gtcgctaaaa tctgatagcc cggaagacct ttttgctggt ccaaaagcat ggcaagcgtg 1973941 tatggctcct cccccgttga gcaggcggca ctccaaattt ttaaaggcct agaggtcttg 1974001 attaacggca gaattgcagt ctcaagaact tcccatcttt tataattacg ataaaattct 1974061 gaaacattga tcgtcattct gtccaatgtt tcatttaaga gagcttgatc cttttccaat 1974121 gccgcagcaa agtccttaaa gctttggaac ccctttttct cataaagtga cgttagcctt 1974181 ctcttcattt gtgcttcttt atatagtgtt aaatcgactc cggttaattg tttccatttc 1974241 gttgtaaata cgctgtatgt atccatctct actctcccag tctcgctgtc tttttgtcct 1974301 agtatagctt gttttatcag gaaattgtat tgtttcaata aaaaaatcag cttttcagct 1974361 gattttagat cgttgggaaa ggcagaggtc tgatgcacac tgccattcaa ccctttattc 1974421 actttaatgt aaacctttac aaaacagaac aaaaaccggc ggcgttatat gttgccggct 1974481 ctgttgctta ttttcacaat gattaataga tccagcctgc cataagctgc tgatatgata 1974541 ctaattcttc attcttaaag aaaatgttaa tctcgcgttc tgcactttcg agagaatcag 1974601 agccgtggat gatgtttttt ccgacaaaca tgccataatc cccacgaatc gtaccaggta 1974661 aagcttcttt agggtttgtt ttcccgatca gctgtctcgt cacttcaatg acattttcgc 1974721 cttcccacac cattgcgaat acaggtcctg aagtaataaa ctcaacgagc tctccgaaga 1974781 aaggcttacc ttgatgttcg gcgtagtgtt tctcagccat ttgttcagtc actctcatta 1974841 acttggcgcc agctaattgt aagcccttac gttcgaatct agataaaatg tccccaatga 1974901 gctgacgttg gacaccgtct ggtttcacca tgataaaagt cttttccatc atattctcca 1974961 ccccatcatt atgtatgtat aggctttcac actgcacacc gaaatcgtaa catctttctg 1975021 ataattaatc aatccggggc ggagaaattt cttaatatct acaaaaatta aaattttctt 1975081 ttaccgatat attttgcgat ggctgcaaga gacgagcgtg cgcgccctcg aggaagcgtg 1975141 tttaatttct gaaaagcttt ctgcagatac atttcgctta ctgccataga tgcttcaatt 1975201 gcatctgttt ttttgatttc ttcaatgatt ggttcaagct gttcctgcgt tgtctcactg 1975261 ttaatcaatt taagctggtt ttttaatgca ggatttttca gggcatacag cactggcaat 1975321 gtgacgtttc cttgaagcaa atctcctcct acgggtttac ccagctcttc ctcagttgaa 1975381 gtaaaatcaa gaatatcatc aataatctga taagacatgc cgacgtaata cccaaaccag 1975441 tacaatgcct tatgaatctt ctcatcagct ccagacgcaa tggcaccaag ctggcagctg 1975501 accgcgatca agagagctgt ttttcttttg atacggcgga gatacgttct gagattttgt 1975561 tccatgttgt atttgtcttt gatctgctca atttccccta gacaaacttc aacgatcgtc 1975621 tgtgacaaaa tcctatgggc tttcggttcg ttaattctcg tcatcatttc aagagatccc 1975681 gcaagcatat aatcgcctgt gtacatcgca atacgattgt cccactttgc tttgattgtc 1975741 ggttttcctc ggcgaagctc tgcatcatca atgacatcat catgaaccaa agatgccatg 1975801 tgaatcattt ccagagtgac ggcgacatat ttaatcttat taatatcata atcgccaaac 1975861 atgccagaaa gcagcacgaa aacaggccga atacgtttcc ctccggcctg cagcaggtga 1975921 agacctgcct cgcttaaaag cgggtaatcg gaacgtacgg tttgttcaag ttctctttcg 1975981 attacatcaa tatcgtcatt taaaaaagag taggccattt taaatttcat atcattcacc 1976041 caaacatctg tgttttcatt tccatccgat atgcgtggca gcgactccgc cagtaaacga 1976101 atgatattta acatttttca ggcccgcctc ttcaaacagg cctgccagtt ccttcattcc 1976161 agggaaatct ctggctgatt cttgaagcca agaatattct ttatagctct tcgcaaacag 1976221 tttcccgaaa aacggcataa tatacttaaa gtacataaag taagcctgtc tgaatccgaa 1976281 catttccggc tgggacgttt ccagacatac cacctgcccg cccggcttca ctacacgtct 1976341 catctctttc agtacagtca agtaatcagg gacattgcgg agtccgaagc caatggtgac 1976401 ataatcaaat gtatcatcat caaaaggaag ctccatcgca tttccgtgca gcagttcaat 1976461 ttggctgaat ccgccgtctt ttactttctg ctcgccgaca ctcagcatat tttcactgaa 1976521 atccaagccc ttgatctcgc cgcttttgcc tgccgctttt gcaagagcga tcgtccagtc 1976581 agccgttccg cagcagacat caagtgcttt tgcgccttcc tttacattca tgatgcgcat 1976641 cgttttgtcg cgccattttt tatgctgctg aaaactgatg acagagttca tttggtcata 1976701 atttttatat attttttcaa atactccgtg tacgcgctgt tcttttgagt cctgcataat 1976761 ggtttaccct tcttccactt tctgatgata ggtttgatct tggctgattg tcttcagacg 1976821 gtttattaaa atgttctgaa taggtgaatt tagaggcaga agtgactcaa tgctgttttt 1976881 cgctttttta aaacaatctt ctaatatctc ttcttttgtt tttcccagct gtataaaact 1976941 gccgatcaca tccagaaatg catcatttcc gttcataagc cgcttaaata caaaaaaatc 1977001 actcgacagc tttttccagc gcgggaggtt gaagtgttcc gccacacgat ggaataaagc 1977061 tgattcaacg atgccgacac tttcgaaaaa atcgttttcg tccttgaaag aacggtcata 1977121 cagacgaatt ttatgttcgt tgatttcttt aatggctgta gcaagcgtcc gaatcatgta 1977181 gatatccttc atttcagata gtaaagagta gtacagcccg ctgaaataat cgcccgcgag 1977241 aacagtcaat tggcggtttt tgttttcgtc tcgttttatg actctagctg tcgtcacttc 1977301 atcatgggta tcaagggcgc tttgtacaag catcgctgtt acaatataat tttctctgtc 1977361 gttgtttttt atgtcggctt cttcaaataa agcatgaaaa agaagaagct tatcctcatc 1977421 aattttcggc gcagaaatat gcttcgctaa ataaggatga gacagctttt gttttaattt 1977481 cgtgttcaga ttggctaaag ttccgtagat gtcttgcaaa aatatcaccc ttgtccccaa 1977541 attcacattt atttcttaat ctatgtatga gttttatctt ttcattcgct tacgcaggta 1977601 tcattatagc ataaaaaaaa gaaattggct gtatcctccc gctgtttgcg agcatttgct 1977661 tttaacagcg gggacagcca gcttattttt tttcgctttt catttctccg tacgcggttt 1977721 gaatcagtgc ctctcctctg actttaatgg cagaagtatg ctctgtaaac tgagcgatga 1977781 tcacttctcc cttgtcgagt ttttcggaat ggtgaaactt tgtgtctgtt cctcttgtca 1977841 ggccgatcac attcactccg tcctcaacgg ctttaatgac gacaaaatca cttgaatgct 1977901 tttggttcat ttatagcacc ctctatcttt attagtcctg gcgtttaata tgttccaata 1977961 cttctgcacg ggcagcggca tcatctttaa aaacgcctct gactgctgaa gtcacagttt 1978021 tcgcacccgg ttttcttaca ccgcgcatcg tcatgcacat gtgttccgct tcaaccacta 1978081 ccattacgcc atgcggatca agcgtttcta cgatgctttc tgcaattgta gaagtgatgc 1978141 gttcctgaag ctgcgggcgc tttgcaacgg cttcaacggc acgtgccagt ttgctgagtc 1978201 ctgtgacctt tccgcctcgc gggatatatg caacatgtgc ttttccataa aagggaacaa 1978261 ggtgatgctc acacatagaa tgaaacgcta tatcttttac aagaacaagc tcctcatggt 1978321 tttcaccgaa gatagtctgg aaatgttctt ttggatcttc attcaagccg gagaatactt 1978381 cggcatacat ctttgcgact cttttcggag tatcaagaag cccttctcta ttcgggtctt 1978441 ctccgatcgc ttctaaaatt tgacgaacag cttgttcgat ttgctcttta ttaacttctt 1978501 tcatgttcta tgtcctccac caatgaatac atttaatttc gattctagca catatgcccc 1978561 gctaaaagca aagtgaatgc cctgtcagga agcccatgct cttgaaatat gaaaagcccc 1978621 ttagaaaggg gcttttctgt gaagaaataa agtgtatgta agctagatgc atacacgatc 1978681 tatattcaca attattttcc ggcaactgcg tctttaagcg ctttacctgg tttgaaagca 1978741 ggtactttgc ttgctggaat ttcgatttct tcacctgttt gaggattgcg tcctttacgt 1978801 gcagaacgtt cacgcacctc gaagttacca aaaccgatca gttggatttt atcaccgttt 1978861 ttaagtgcat ctaagatcgt atcaaaaaca gagtcaactg cttttgtagc gtctttttta 1978921 gacaattcgc ttgcttctgc aaccgcattg ataagttctg ttttgttcat gcctttcacc 1978981 tcctcccaaa aggatacatt cagttcgttt attatcattt cttcacagtt cagtctgatt 1979041 ctaaacctgt ctcagaaaaa aatgagagca agtaagagaa agacaattaa acggcttttt 1979101 aagaaaaact gcactctgag gaatgtttgt ccaacaaagt gaagaatttc tgtatgtaga 1979161 gtaacacata taaaaagcca tatcaagcat tttaaagcgt caatcccttg ctcgtcaagg 1979221 atttaaggtg atttaccgaa cgaatattcc tttttttcct tttttcatcc tattccttga 1979281 tccttttcca ttattaagag caaagaaaaa agacctccca ttctataaag aggtctaccg 1979341 gtattacagg atgatggcga ttaagccgcc agagccttcg tttatgattc tttctaatgt 1979401 ttcttttaat ttataccgtg cgttttcagg catcaatgac agctttgcct gaatcccttc 1979461 tctcacaatt gagctcagcg accttccgaa gatatcggaa ttccagatgg agagcggatc 1979521 atcctcaaag tcctgcatta aatagcgtac aagctcttca ctttgttttt ccgttccgat 1979581 aatcggggcg aattcgcttt cgacatctac tttgatcata tggatcgacg gagcgacagc 1979641 tttcagcctc acaccgaatc gcgagccctg ccttataatt tccggctcat cgagactcat 1979701 atcagctaaa gcaggcgctg caatgccgta tcccgtctgt ttgaccattt ttaaggcatc 1979761 agacacttga tcatattctg ttttcgcatg ggcgaagtct tgcatgagct caagcagatg 1979821 gtctcttcct ctgatttcga cgcccacaac ttcttttagg atttgatcat atagatgatc 1979881 aggcgcgtac aaatcaattt ctgccacccc ttggcccagc tcaattccgg ctaatccggc 1979941 actttcaatg aattcaaact cgctgaattg gccgacaacc ctgtctacgt cccggagccg 1980001 tttaatatcc ttaaccgttt ccttcacgga ctcctgatag ctttcacgca accaatggtt 1980061 ttctttcagc accattaccc agcttgggag attgacattc acttctagca ccggaaactc 1980121 gtagagggcc tctctgagca cactcagcac atctgattcc cgcatgctct ctacactcat 1980181 tgccaatacc gggatatcat atttttcgct taaatcctgg cgcatggctt ccgtttccgg 1980241 gtgatacggc ctgactgagt tgatgaccat aataaaaggt ttgccaacct ctttcagctc 1980301 ttcaatgact ctttcttcag cctctatata gtcacttctg gcgatatctc caatggtgcc 1980361 gtctgtcgta atgacaactc cgatggtcga gtgttcttga atgacttttc gtgtgccgat 1980421 ttcagcagcc tcatgaaatg ggatcggttc ttcgtaccaa ggcgtattga tcatccgcgg 1980481 cccgttttca tcttcatatc ctttagcgcc gggcactgtg taacctacac aatctactaa 1980541 tcttatattc acatcgagtc cgtctgacac atgaacagac atcgcctgat tcggaacaaa 1980601 tttaggctct gtagtcataa tggttttgcc ggctgcgctc tgcggcagtt catcctgcgc 1980661 tcgggcccgg tctgcttcgt tactgatatt cgggagcacc acaagctcca taaatttttt 1980721 aatgaacgtg gattttcctg tacggacagc acctacgact cctaagtata tatcgcctcc 1980781 tgttcgttca gcgatatcct tgaaaatatc gaccttttcc aagtgatccc ctcccggact 1980841 tcctatcctt ttcaatttta ttaagctctt tcaatcaaac acaggacact atatgtgtat 1980901 gacgttgtcc tatttgaata tgacatcttt agaaaatttc tcatcctcaa tctattaata 1980961 taaaaaaacc tttctcccta tttgtatgca agggagaaag gttcattcct ttttcatatc 1981021 attttctaaa aaaacaggtt cctgtttgtc atttaccgta tattttacag aaaacgcggg 1981081 gacaaagggg gtttcatgcc aaatcatatc ctggatttca gtcccgggtt taaacgtttt 1981141 tttgcttttt ttgaggcaag aagccagctc agtccggtaa tcggcatata tttctccgtc 1981201 tccgtcaatc ataagcggca aggaattccc tgagattggg cttgtcactg taagagagct 1981261 gccatcccca agcttcttct catcgagtgt aaataaatca cgagatagca catccttgta 1981321 aggcggatat tgatgctcct gacgatacat ttggatgcgc aatttcacat cgcgaatttt 1981381 ttctgccatc tttagatcaa ttaatttaac agtcggatcg ttctctacgt caacaagcac 1981441 gtattgatag tctcccccgc tttcaaatgc cgtacttgga ggttcagcta tgtatcttgg 1981501 cgctaaccgg ttaaagtcta tcggatattt ttgatatagc ggtgtcgaca tatctttggt 1981561 ttgaatagga agcagccctc catttgcctt ttgaaattca tcaacagcag attgaacctg 1981621 ctttagctgg tcttgataag gaatggcatg cacactgctt ttccgttcat ttggatataa 1981681 acatccggat aaaaacacga ctgccgcaaa aatgattgcg cacttcagtt tacccataca 1981741 gcacttcctt ttacagcttt attcattgac agggccgcta aaaaccacga caaacacaat 1981801 aattccagat atgagcatac acatgtatgc gaatgatgaa atcgcaatct tcaaaaaacg 1981861 gttttggcac ttaaagcggc ttaaatagat ggaagctaca gccagaaaca tcagacccat 1981921 ggaccctaga gcaaaccaca ttttcatcaa tgccagattc aatgacgtgc gcctccccga 1981981 tatgtaagat ataagcgtta tattatattt taatatacag cgccggaaaa gatcaaccag 1982041 attttccatc cattgataga acaaaaaaac tgaagcaaag agggggacct tcgcttcagt 1982101 caacttgact atattcacct gcacgtttaa gaaacactct cttggacttc gatgctatag 1982161 tatgcgactt ggcatacaga tgcatcctct attgcctaaa tcggcaaaat gtttcaggag 1982221 atcccaagac ttgggtgttc ttctgttttt cgggctttcg ttcaattaag atatgcgatt 1982281 caccatttga ttgacacttt tacttcactt gattttcaaa cgtatttacc aaatcctcca 1982341 tctcgtgggt tttccctctc gccattaaag attcaacagc ggtttccact ttttgtccgt 1982401 tgaataggac ctgatggaga gcttctgtaa tcggcatttt aacatcatat ttcttcgaaa 1982461 gctgataagc cgctttcgtc gtgcggacgc cttcgactac cattcccatc tcttcaagaa 1982521 catcttcaag cttgtaccct tttccgagca aattgcccgc acgccagttt ctggaatgaa 1982581 cacttgtgca cgtcacaatc agatcgccta ctcctgtcaa tccagagaac gtcaagggat 1982641 ttccgcccat tttcgttccg agtctcgcga tttcggcaag tccgcgtgta atcaaagcag 1982701 ctttggcatt gtcaccgtac cctaaaccat ctgtaattcc tgcagcaagg gcaataatat 1982761 tttttaaagc ccctccgatt tcaactccga taatgtcagg atttgtgtac acccgaaaat 1982821 tgtgattaat aaatagatcc tgcacctctt ctgctgccct catgctcttt gaagatgcag 1982881 taacagttgt ggggtgccgc agccctactt cttccgcatg actcgggccg gaaaggacaa 1982941 cgatatcttt tctgacatca ctcgggagct caatttccat aatttcagaa atgcgcagaa 1983001 gtgaatctgg ctcaataccc ttgctgacat gaacaaagac tgcctttttc gttataaaag 1983061 ggacagcctg tctcagcact tcccgaattg cttttgtcgg gaccgcaacg ataatgacat 1983121 ctgcgtctga aacagcctct ttcatatctg ttgttccttt aatggatgta gacagcttaa 1983181 cattcggcaa ataatctttg ttttcatgca actcattaat ttgatgaatt aaatctgcac 1983241 ggtgagccca cacacacact tcatttccat tatcagttag aactaaagcc agtgctgttc 1983301 cccaactccc cgctccaagc attgtgactt ttttcatgtt tgattcacac ctttttattt 1983361 tctagctctt gcaaatattt tgattggtgt cccctcaaaa ccgaacgcgt ctctgattcg 1983421 gttttctaaa aaccgttcgt atgaaaaatg catcagttcc ggatcgttta caaacacaac 1983481 gaagcttggc ggctttaccg acacttgagt cgcatagtaa attttcaaac gagaaccgtt 1983541 atgagtcggt gtcggattca ttgccacagc gtccatgatg acatcattta agacgtttgt 1983601 ttgaactcga agtgaatgat tttcactagc tttgataatc gcaggcatca gagtatggat 1983661 ccgttttttc gttaaggcag acataaatag gattggcgca taatccagaa attgaaaatg 1983721 atcgcgaata ttttcttcaa attctttcat cgtgctctca tctttgtcaa cagcatccca 1983781 tttgtttacg acgatgacga cggccttgcc cgcttcgtgt gcataaccgg cgatacgctt 1983841 gtcctgttca ataatgcctt cttcgccatc cagcacaacc gccacgactt ctgagcggtc 1983901 aatcgctttt agcgcccgca gtacactata cttctcagtc gtttcataga ctttcccttt 1983961 ttttcgcata cctgcagtat cgacaatgac aaactcctgc tggttgtaag taaatgacgt 1984021 atcaacagca tctcttgtcg ttccagccac gttgctgaca ataacgcgtt cttcgccgag 1984081 catcgcattc acaagtgaag actttccgac atttggacgt ccgatcagac agaattgaat 1984141 aacttcttca ttgtatttcg tttcaggaat gtttttaaaa tgctctgcaa cggcatccag 1984201 taaatcaccc agtccgagtc cgtgtgttcc cgaaattgga tacggctcgc caaagcctag 1984261 cgaataaaaa tcataaatat tcgctctcat ttctgtgtta tccagtttat taaccgctaa 1984321 aacaacaggc ttttttgtgc ggtacaaaat tttcgccact tcttcatcag cagctgtcac 1984381 gccttcacgg ccgttcacca taaaaataat cacgtccgct tcatccatgg cgatttcagc 1984441 ttgctggcga atctgcgcta aaaacggctc atcaccgata tcaataccgc ccgtatcaat 1984501 caaattaaaa tcataattca gccattcagc cgagctgtat atccgatccc ttgtcacgcc 1984561 aggggtatct tctactattg aaattctttc tcccgcaatc cggttaaaga ttgtggattt 1984621 tcctacattt ggtctcccga caatggctac gacaggttta cccatagtac ccttcctttc 1984681 aatccagccg ctttcatttt tacataaatt ttcaaccggt tattaaaatc atttcattca 1984741 cttttatgaa aagaaaccct tcagaggaag ggcttaactc atttattata tcagttttta 1984801 ctgggatcac aactattctt aaaaatgttt cacgatcaaa tacacgtcat ctccgattct 1984861 gtgagctatt ccatcaagga tcgcctcaag atttttagcg aaaagctcca tctccttttg 1984921 gtcattgcaa aaaaagacag gtgctccccc tgcaacccga tttcgatttg tcgtgattac 1984981 agacaaaatc actttcgtaa gagattcact catcctatca ccttatcctg attcttgata 1985041 aattcagtcg gcattctaat cgcattttcc agggttggaa cattgctaat aatttgaaca 1985101 gccgtttcgg gatggtgaat ttgcgggaga acaaatactg ccactctccc atcatttaaa 1985161 tcccgttttg caattggtgt caaagatggc tctcctgaat cccgataaac cccgagcaca 1985221 ttggaaacat caaataaaat ggcctgacgc tgccctaaat ttgctatcgt cgctgctgaa 1985281 ttaaagtttt tcggcgtcaa aataaagccc atgccatgct ttaaaatcag ttcctgtttc 1985341 tctggaagcc cgatattcat catataaata ttatcaacaa acagtcccgg accgtcaaag 1985401 cgcggcttta tgtactcgat atctacaata tccttcaaca cactgcccga cataaacttc 1985461 atggccagta aaaaacaaac gacagccgct atgactgcag cccagatgga taaaaacaca 1985521 tacgcagagg ttgtcaaaag cgctgtaaag atcacaatat aatttctgct ttcaaacgca 1985581 atggcaatcc cctcaatata tgtgcttccc cttgagacaa gttcatacga atccatttgc 1985641 gtcaatgtgt tccgctccat gtttcggaca tctctaaatt gcgtcgctgc caatgttaaa 1985701 aatgtgatgg ccgtaaattc ctcctgcaaa agcgccggca taataattgc acctaaacca 1985761 gccgctatca accccagtgc gatgtgaatc actttcccat gaacataggt cggatactgg 1985821 cggtaatccg ttttcagcat ataaagcctt gtcgcaattc cggcaatgac cccagcaata 1985881 atcggataga tgtaatcact catgacattt tggtagctcc tttgtttgat cttttgcttt 1985941 tctgaccaat ctggcttgcg aggtgttcgt atttagatat gccaaacagc aatatcatcc 1986001 ccgcagaaca cgcattcagc cattgaaagc cgccgacagc catagccccg gccaacttct 1986061 ggatcacaaa tgaatacacc agttcgcctt ggcacatccc taggacaaat aagacaagct 1986121 gcttctcaaa attcctttca acagaagctg ttaaaagcac tattaatata acagcagccc 1986181 actcaggttt tatgatgaac caaaccgggt catataatgc aaaaagataa acaaacgcat 1986241 acgcggcaac aagcgtcaga tagaccatga tgtaacgaaa acgatacatt cccaaatacc 1986301 cggcatagac acatccgcaa acgaaaaaca tcaaatatgc agcattcagg gaaaaatata 1986361 aagcgatgtc atgtatgctt agaataatat tagttaaaat aaagacagag acggcaattc 1986421 gtcttttcgt cttttcaaaa ataaatgttg tcagaaccca cagaaaccac attgaccaat 1986481 agtaataaaa ttgttccatt ttacttcctc catattccca gtatggagtt caagcacatt 1986541 ttttaaacaa tcgatctcac attaaggagt atgatcatgg gaaaagacag acaagagaaa 1986601 aaactcaaag cttcaggcag agtcgaatca gatcgcgacc agtccattca ctatgacgga 1986661 gcgacaagcc ttgaacaaaa cggaagattc aaaaagcgaa aatcataata caaaaagccc 1986721 aaaccacata tggttttggg cttttatcat ttatcgcaca ctatagcttg atgtattgac 1986781 ccctctctct gtgagccaat gatgggtttc acctttgatc acaaggggcg ccttttgtaa 1986841 atcggcaatt gttctggcac ccagcacggt cataatcaac tttaattcct caaggatcag 1986901 ctgaatctcc tcaagcagtc cttcctcacc gctgtcagtc agcgctttta aaaaatgccc 1986961 tgccattccg gtgcaagagg cccccagcgc aattgccttt gccacgtcaa gcgcatcttg 1987021 cagaccgcca gaggcgatca tggtgcttgc aggaaactca gagcggattt ccgccaaact 1987081 tgcagctgtc gaaatgcccc acgaattaaa aaaggagatt tgccgctgtc ttcggagatt 1987141 ttcgattttc gagaaatttg ttcccccgta accgccaatg tcaacagctg cagcaccagc 1987201 ttcatacagc tttcctgctg atgctttgct cataccgaag ccgacttctt tcacaatgac 1987261 cggtacactg acccggctgc aaatttgttc aatgcgtttc aatgcgccgc taaagcttct 1987321 gtccccttca ggcatcacaa tttcctgaat cacattgagg tggatctgca gtgcgtttgc 1987381 tccaatcatc tcaacggctt cctttgcctg agcagccgtt gcctcgcttc ccaggttggc 1987441 aaaaatcagc ccgtttgggt tttcctttcg aacaatttca taggaaagac gctctgatgg 1987501 atcttttaat gctgacattt gcgatcccac agcaagggga attccagcct gagaagccgc 1987561 tcgcgcaagc gatttattaa tctcatatgt aagttttccg ccgccgccag tcattgcatt 1987621 gataaaaatc ggcgaactgc ttgaaagttc gccgattttt gtggaaatat ctacttgttc 1987681 taatgcaaga tcgggcagac tgacgtgaac aaacgtaata tcatcaagac ctgtttcccg 1987741 cttctggccg atggacaagg catgattgat gtgttgtctt tttcgttctg ctcgagtcac 1987801 gtttatcacc aattatttta gtttattcag cttatctccg atcagatctc caagctggaa 1987861 gccagtgctt gtttcttcct tcgcttgata ttgacggtaa tcttcctggt cagctttagg 1987921 cgtttcttca agttcacgca tgcttaatga aatgcgctcc tcattttcat tcacatcaag 1987981 aaccttcact tttacagtct gtccttcttc aaggacttca tgcggcgtgc cgatgtgttt 1988041 attggaaatt tgagaaatat gaacgagacc ttcaacacct ggaaggattt caacaaaggc 1988101 accgaagctt acaagacgct gtacagttcc ttcaagcaca tcgccaggct tcactttttc 1988161 gccgatttgg ttccaaggtc caggcagtgt atctttgatc gataaagaaa tacgttcatt 1988221 atcacggtca accgataaca ctttcacttt tacttcttgt ccctcttcaa caacgtcaga 1988281 cggcttctct acatgagagt gggaaagctg tgaaatgtgt acaagtccgt cgatgccgcc 1988341 aatatcaaca aacgcgccaa agtcagtcag gcgctgtact ttgccatcaa gtacacttcc 1988401 aacttcaaga gactgaagaa gttcttgttt tttattcgct tgttcacttt caacaacagc 1988461 acggtgtgaa aggatcacgc ggtttttatc acggtcaagc tctacaacga gcagtgacag 1988521 tgtttttcct ttatagtcag tgaagtcttc aacgaaatgt gcttcaacaa gtgatgccgg 1988581 aataaaaccg cgaacgccga tatcaacgac aaggccgcct ttcacgacat ctttcacttc 1988641 agcttcaaac acttcttttg tttcaaattt tttctcaagg tcttcccaag cgcggtctgc 1988701 atcaacagca cgtttagata aaatcaaagc atcgtcttcc acttttgtta ctttcaggtc 1988761 aagctcgtcg tctactttaa caacatccga tgctttctct acatgaagac ttgataattc 1988821 actgattgga ataataccgg attgtttgac attgataatt tctacatcta catgtttgtc 1988881 ttctaccttt gtcacaatcc ctttaactac atctccaacc tctggcactt gaacatcaat 1988941 ttgattcatt tcctctgtca tttgaataac ctccttggtc caaacctaca cagcttaatt 1989001 aaaacggttt gaaagctgaa catataacat gcccgctttt agccgaatat gtattaaaga 1989061 atcatccaaa aaagtttttt gaatgatcaa taaaaagttt tattagtatt aacttctaat 1989121 aaaaggacag gtttgtcaag caataacatt ctatcttcgt tgaaaaattc aaaaaaagtg 1989181 gcatttgcca tcctcagcgg gacttttgct ccacagcctc gaggatttta tcagctacct 1989241 cttgaatgga aagcgatgtc gtgtcgattt caagagcgtc ttctgcttta cgcagcggag 1989301 atacttcgcg ctctgaatca agcttgtctc ttcttgcaat ttcctcaatt aatgtttcgt 1989361 agttgacatc aaagcctttt ttcacatttt cttcataacg gcgtttcgct ctctcttcca 1989421 cagatgccaa aagaaagatt tttacttctg catttggcag cacatgcgtc ccgatgtcac 1989481 gaccatccat gacgacgccg cctttttccc caagctgctg ctggcgtttc accatttctt 1989541 ctctgacact tctgtgcttg gccgcaattg aaacttggtt gctgatttca tctgttctga 1989601 tcgcctcagt tacatcggtg ccgtttacaa acactttttg tccatctttt gttgtaatca 1989661 gctcaatgtc tgtccgcttt agcagctcag ccagtttttc ttcatctgtc agatcaacgt 1989721 tttcctgtaa agccgcgtac gtaatcgccc gatacatcgc tcctgtatca atatatatgt 1989781 acgatttttt ctcagccaca attttggcaa cggtgctttt ccccgcagct gccgggccgt 1989841 cgattgcaat cgataatttc ttttccataa ttcctctcct tgctcttttc tcctctaagg 1989901 attgtatcac gaactttatg aaaaagggtg aaaaattgat gaataattaa tgtttgaagg 1989961 tttcaatcct attgttttcc tccattttat ccaccccttc atattgaatc acttttgata 1990021 cgtatggttc aatatgctga tagtgaaaaa gaaattggac accaagtaaa atgatggcct 1990081 gaatgaacaa taatttgatc agcagccgtt caaatgtttt cattggagca cctccattac 1990141 aaatagtatg gaagtgtttg ccgatgttta ttccattcgg gcctttcttc tcttatttaa 1990201 ctggcgcctg atgcagtatt gaagcaaagc ctgctggtca cctgctgcaa tttctgaata 1990261 ctctaaagtc atttttcgtt tttctgactt ggggtcatta aagattcgtc tgacaactgc 1990321 ttctgtttct atttgacgtg tgtgctcctc ttcaggaaga cggatgatca ggcgcaatga 1990381 ttcccccgat tgaaaagaaa ggccatcagc taaaaccacg gcgatgccgc ctgcactgat 1990441 gttataggat agtgtgcgga tctcttcttc atttcccggc tgaatttgca catctaatac 1990501 cgcatcagtt cttacatatt ggcggcgctg gattcttttc attttttcac ggggaggcat 1990561 ttcaagacag atcatttgaa gtttgtcctt cactttacct tttatacggc ttataaagcg 1990621 ataaggaact tcgtcttttc ccacaaactc taccgttact tccatatcgt tatgtaaaat 1990681 cacagttcgc cctgtaacta catcaacagg atacgcgatc aaaagttcat tgttttcgat 1990741 gctgaccgcc ttgctttttg cctttttcaa ttcattttct tctatatatt ctaaaagtac 1990801 attttctcca atctctatca ttgacttcac tctttcgcat tcaatatact cacgttttta 1990861 ttaaagcacg taatgaaaaa aaggaaaaga catttagtcc tttcctcctg tttttatagg 1990921 tctttatata taggttctgc attttttagt ttttcaacct tttcttccga tccgtctttg 1990981 gcattgatat acattctgaa tgtgtcattt tcaattgtcc caagcatttc gtagcataac 1991041 acttcttgac ctagttcatt tgtaatcaaa gcgagccttg tttctctcac ttgtacattt 1991101 ttatttaatt tagactttgc ctctgcttca gtaattgcag gcttaggtat ggttcttttt 1991161 ctgtgagatg tgaggaagtc tcttgctgaa aagccgacaa cctcaccgtc atccaaggcc 1991221 actttcatac gaattgcctc ggggtacatc cggactttat tttcaacagg aacatatgaa 1991281 aatacaccga ttttatcata ttgggcactt tcatcaattt ccaaatcatc tgtttcaaat 1991341 ccgtttttct ttaaaaatgc aagcgctcgg ttcgatccgt catttaaact gattttctga 1991401 tctttcactt ctctgttttg gatcaagtat accggatgcc cgcccttctt cgtaatatcc 1991461 atataaatca ctgctttatg gtctgggtct ttcatgctga tgctatatac atcgcgattt 1991521 gttttttttc cgctctttac cactttaatt gaataattgt catctggggc aaagcgctca 1991581 gcaatttgtt ttgcttcctg ttcggaaatt tgttttccct tcagatggct gaagcctttc 1991641 tcttcttttt tcgtactggt gaaactcggg ccaagatcag tgccagtgga gaatgcacca 1991701 acattttttt cgactgtttt aaagctgttg ataatcgtat tatcactttg tttttcgtca 1991761 gaagccagag ccatttctac gtccatccag cgaaggtttt tgctcatgac aaggtgctga 1991821 acatgacgca attcattttg tatatcttcg gactgctgat atagcttatt tagtgatgta 1991881 tactcgtttt tatcaagcgg cttttggtcc aaatctctga ctgacgtttt atagctgaaa 1991941 tcgccgatct ttgataatag ctcttcagtt ttattaaacg gcattaatgt aagcggcagc 1992001 tgactgacgc tgttatgagc ttctgatgta atcctccaca catcgatcaa tgcaggcgac 1992061 agtgattttt ggctgttcat ggcaagtgtt gttccgattt tatcatgaag ctgatccacc 1992121 tgataggtaa gctcatgaaa cgcccgctga tagttatttt cagcatgaag aagaactgcg 1992181 tctttttcct ggtgttcttt gtatccccag tagcctgtac cgactattgc aataccaagc 1992241 acggcgatta aaattcctct gatcatttat cacacctctt tttatgcttt ctcatatctg 1992301 ctactcacag aaaatgtgtt taccgattct tttaatctgc ggacgccccc aaatccacgg 1992361 acttgtagcc gtatccggat taaagtagta aagtgcttcc tctgatgggt cccagccatt 1992421 gatggcatcc agcactgctt ctcgtgccgt ttcattcggc tgcatgtaaa tttgtccgtc 1992481 ggctactgct gtgaaggcaa gcggctcaaa aataaccccc gctactgaat ttggaaataa 1992541 cgggctgttc aaacggttta aaatgactgc tgcaatagca acctgcccct cgtacggctc 1992601 gccccgggct tcgccataaa ccgcttgagc aagcagcctg atatcgttgt tggaaaatcc 1992661 accaggcatg ttcgctgcta ccgcatcctg ttttcttgct tttgctggtg tattgttttg 1992721 ctgtttattc gcattcgctt taggcttctg cgttgttttt tccgcaggct gtttctgccg 1992781 tgcttctgct tgttgtcttg ccttttgtgt tgctgctttt gatggtttcg tctgatactt 1992841 tagcggaatt tttccgtaat gcgtgaatgt attcccttta ttgagctgtt ccatgacata 1992901 ttcacgatag tattttgatt tacatattaa ggtttgcttt gttttagctc ctacaaggcc 1992961 gtcaacctct tttaacccga attgatcctg aaaatttcga actgcccagt acgtccccca 1993021 tccataaacc ccgtcaattt ttccgttata atatccgttg tattgaagac gcgcctgaag 1993081 ctcgaccaca tcatcccctg ttgcccctct ttgaatgacc tgattcgaaa aggcagagat 1993141 cgtttcagta ttaataaacg tcgttattgt aaaggaaaaa aggatgagac atgccataat 1993201 cgatcctttg gacttcatct tttcaagcct cctactgcaa atttttaagt gtaatcgtat 1993261 tttctgtaac gaggttattt ttatacactc tttccttgtt atccctcaga acataaaaac 1993321 tgcacacaaa aaagccgcac ggttgctgtg cggcttctat acttgcatca tattaacgga 1993381 acgggctttt ttcgctttac gcaaaccaaa ccaccataaa aataccataa atggaagcat 1993441 ataataaatc caattgctaa gcgctgttag gataaaatca tatgatccat gcaaaaggga 1993501 tgggacaact aaagaaagag taagccactt tacacgcgcc ttatcagcgg aaaaacgggc 1993561 ttttccaagg taaaatccca ttataacgcc aatcaaggca tggcatgaaa caggcagcag 1993621 cgccctgaca aacgcatgct ccacgccgtg gccaattaaa taaagaatat tttcgagggt 1993681 tgcaaaaccg agtgatacac ttgcaccgta cacaatcccg tcataatgct catcaaagtg 1993741 ggcgtgcggg taaacactga tcatcagtat aaaccatttt aatgattcct ccaaaaaccc 1993801 cgaagataaa aaagaaacga aaaagcttcc gcctcctaca ttctcttttt caagtacata 1993861 ctggataaac atgatgggaa atacaagaac aaccccgaga aaaaacgacc gtagcaccat 1993921 atgtacaggt tcattatcat actgatcttt taaataaaaa taacttaata acgcgatgcc 1993981 gggggcaatt cctgcagaga tgattgcaaa catcaggcaa cctctttcct ttatattcct 1994041 acatctatcc taccatgttg tttaaaattt tacatctgtc tgcacttaaa aaaacaaaaa 1994101 gagcatacga atgcatcata tgctcctcat ctttaatggt tttctctttt ggcgatttcc 1994161 gctgcgatat gccccccgtg aaacctgccg ttttcaataa atatttcatt tgcattgttt 1994221 cccgcagcaa taacaccggc aataaagaca ccttcaacgt tcgtttccat cgtttcttcg 1994281 ttgaaaaatg gacgccctgt ttctttatca atttcaacac caattttttc aagaaattga 1994341 tgatcgggat gatagcctgt catggcaaat acaaaatcat ttttaatggt aatgagttct 1994401 ttctctccgg agcgaaacac aacttcattc tcggtgattt tttcgacaca agctccaaat 1994461 tccatacgga ttgtaccgtt tctgacgaga gcttcaaatt ccggcagaat ccacggctta 1994521 atgctcggag aatactcatt gcccctatat aaaactgtga cacgcgcccc agatttcacg 1994581 agttcaaggg cggcgtccac gcttgaattt ttcccgccga tgacaacaac atctttatca 1994641 aaatacgggt ggccttcttt aaaataatga aatactttcg gcaaatcctc accgggtacg 1994701 cccatatagt ttggatgatc ataatagcct gtggcgatga tacaatatgg cgtcgtgtag 1994761 gtctcttttg acgtctcaat aacgaatgtg ttattttgcg ttttcgtcac tttacgcacc 1994821 atttcaaacg cattaacacg gatgtttttc cgtttaacga cttcccggta atacgataaa 1994881 gcctgaattc tgacaggctt cctgttctct gtaataaatg ccacatctcc gatttcgagc 1994941 ttttcacttg aactgaaaaa ggtttgatgc gtcgggtaat tgtaaatact gttaacgaca 1995001 ttgccttttt cgatgacgag ggcatcaatg ccaatttgtt ttaggtgaat ggcagcagat 1995061 agtccacaag gtcctccgcc tataataatt gctttttctt gaatcatttc tgtcaactcc 1995121 tgcgattggc atttcacttc atattttcta tttccgaata aaaaaatctc ctattttatc 1995181 ataggagatt ttttattttt atgcaaatca tcaacttata tccagcctct aaaacgcgaa 1995241 gcttcagcca ttttgcgaac gccgaccata tatgcagcga gcctcatgtc aattcttcgg 1995301 ttgttagcca tttcgtaaat attgttaaat gatttgacca tcattttttc taatttttct 1995361 tctacctctt cttcactcca gtagaagcct tggttattct gaacccattc aaaataagaa 1995421 actgttacgc caccggcact tgccagcacg tctggtacaa gcagaatgtc ccggtctgaa 1995481 agaatttttg ttccttcaag cgttgttggt ccgttcgctg cttcaacgac aattttagcc 1995541 cggatattat gggcattttc ttctgtaatt tgattttcaa tcgcagcagg aacgagaata 1995601 tcacaatcca gctccagcag ctcttggttg gtaatggtat cgttgaaaag ctttgttacg 1995661 gtaccgaagc tgtcgcgtcg gtcgagtaaa taatcgatat caaggccttc cggatcataa 1995721 agtccgccat acgcatctga gatgccgaca acttttgccc ccgcatcatg cataaatttt 1995781 gccaaatagc ttcccgcgtt tccgaagcct tggacaacga cacgcgcacc tttaatatcg 1995841 atgcctctct tcttagccgc ttctttaata cagatggtaa caccttttgc tgtcgcagat 1995901 tctctcccgt gagatccgcc aagcacaagc ggtttgcctg taataaatcc aggcgaatta 1995961 aattcatcaa ttcttgaata ctcatccatc atccaagcca tgatttgtga gtttgtaaat 1996021 acatccggtg ccggcacgtc ttttgtcggg ccgacaattt ggctgatcgc tctgacatac 1996081 cctctgctca gacgctccag ctctctaaac gacatatccc ttggatcaca aacaattccg 1996141 cctttaccac cgccatatgg aagatcaatt atgccgcatt ttaaactcat ccaaattgaa 1996201 agcgccttca ccgccttcac ctctttttct gttacgttcg ggtgaaaacg tatcccgcct 1996261 ttcgttggac cgacagagtc attgtgctgc gcacgatatc ctgtgaaaat ctttactgaa 1996321 ccgtcgtcca tacgaacagg tatttttacc gttaataatc tcatcggctc ttttaacaat 1996381 tcgtatacct cttcgggata tcccaatttt tccagagcct tatgtattac ggtttgggtt 1996441 gattttaata catcaagttt gtcctcttct gtatgaccgg tgtttcgatc ggctgccatt 1996501 tgagttaacc tcctagaatc ttctgtttct cacatgctcc ctttcagaga atagtataca 1996561 ccttcatatg atctgtgcat agaataaacg ttatgttttt ccatgttttt taacgaaaaa 1996621 aaactgctga aatcagcagt tttccgttgc attcttatga aaaatgagtt tgtatcgttt 1996681 ctacggcatt accgtccata atgagcttac catactcttg caggcgataa atcgttaaag 1996741 ttgtcggatt gccgtattca gccagaaccg ccacaacccc ttcagccgta tgtgacccta 1996801 gatcttcaag gcttaaaaag tactgcccgt catagtggta gacagttccc cctgtgatac 1996861 cgattcgctg taagctttct gaaagctgaa tgatatcttc aaaggaatgg aattgatata 1996921 tgatgtccgc gctttcatca agcttgactt gcatttcgat gtaatcatca tcatactcat 1996981 cgtcttctga atcggcgtct tggttctttg ttacaatcac gaccatccct tgtgcttgga 1997041 gagaatacac ttccactgca atcggtccat tcgcttcaaa gccgagctct gtatttgctt 1997101 cattcatcat atctttaaat aactggtgga ctttaaatga gtccttccag aggtcttctt 1997161 ttgtcaatcc ccggtctgtc aaatcatcga gggttaaaaa gattttgatc ttattataat 1997221 tcagacgctc aagccgcata acgttccctc ctgcctctac ttgcacacaa atcatataac 1997281 acattatatg agatgatgag tcataggttc ttaattgtta tcagtttaca ctgagttcac 1997341 tagtaagaca agcacaatgc agtttttatt gccatacgga tttttgcttt ttagaagtta 1997401 ttctggcccg caaagagtca caatgtgagt ttcaggctca gcacctaaac gaagaggcac 1997461 ttttgtcgtg ccgtagccgt tgctgatcag atatgccgcg tttttaacaa tacctgtttt 1997521 ccccagttca taaggaccga attttccaaa cctgatctgg cctccatggg tatgtccgct 1997581 gagtatcaca tcaataccgt catcttcatt gatttgttca tgaatctccg gattatggca 1997641 aaccagaata ttcagctggc tttcatcaag ttctttgatg gcttcctcat aatgatccat 1997701 ctccatcctg atatcatcaa cccccgcaat cgcaatcgta tgcccattgt atgaaaacgg 1997761 gactgactca tttctcagag tgatgacgcc gtgcgcttta aatatggaat acagcttatg 1997821 ctgcctgact tcataatcat tattccccca cacaaacacg atagggaccc cgaaatgtac 1997881 gagccttttg atgttttcct cgattctcgc actgggcacc ccgccctcag ctaaatcacc 1997941 gccgattata accaagtggg gggcatggct tcgcgctttt tctaaaaggt cttgatcgat 1998001 gagacgtttg tgaatgtctg aaataaaaaa gattgtcaga ggcggcttgc ccttcatctt 1998061 tgataaagga aacgtatgtg tcttcaaatg attgcctttt gctgttgcat acatttttgc 1998121 cgtcattgcc gctgccgcaa cagttagtac accggcaatt ttcactgata gcttcataaa 1998181 aaactctcca ttctttttag aacttatcaa taagacggac aataaaaaaa gacgtttcta 1998241 tcgtttgaga aaacgcccca ttttatttac tttcaaaata tagattaatg tcatatttgt 1998301 gcttcatcat atgaaaaaca gactctctcg ccttccattt atcgggctgc ggccagagat 1998361 cagtgctttt ctgaataatt tcacatctca gtttatggaa atcagtctcg gatttttctt 1998421 cctttttctt gaaataatat gaagtgcagt aggcaaaagc ggttgccagc atccaaaata 1998481 aataaaaggt atggctaagt atttcttgaa gtataagctg aggctccggg cttttgatca 1998541 tgatcataac acataataag cctaggcaga taagtgaagc ccatcgccat ctgcggcatt 1998601 gtgctgcata attttcgaat ttttgttttc gttttaccag cgcttggagc atctgtttgg 1998661 tcggcgcgtc tgtaaactga tccagctgat tccataagga ttccatacgc ttcacacctt 1998721 gtccattttc attgctacaa tatatgaacg taaaataaaa ataataccct attcatccat 1998781 taaagggatg tccaaaactt gtccggtgta aacatcattt ccattcagat gattatatgc 1998841 tcgaattttt tcttctcctg tccggctttt ataatacttc atggaaatgc ggtatagcgt 1998901 ttctttcttt tggacggtgt gcttgacaac gcgattcggc acattttgaa ctggctcagc 1998961 tggctgttct tgctgttgta ctgttgattg ggaagaggaa gcagccgcgg cggttgcttc 1999021 ctccttattt ggcgagtctt ctttttccgc tacagcagtc tgtttcttat cagcagctgt 1999081 ttgctctttt ggcttggaat cttctggctc tttttttgac tccttctgca gtgcggtttc 1999141 tttagtgtct gcggtatcgt ttttatcctc tgatttcggg acaacctcat atttgctttg 1999201 gctgctgtca ataaaaacat cttcataatc gtcatgatta tccgggtggc tctttagata 1999261 aaataaggtg actaaaacga taaccggcac aaatacaaat attactgcga gtactgtgaa 1999321 taatggcgtt tttgttttgc cttgcttttt tttctgttct ctttgatttt ttacagattg 1999381 tcttgtcgga aggctttctc catcatcgac ataatcgtcc gccaatgcgg cgttttgatc 1999441 ttcataaaga ttctgggctt ttcttctctc tactctcgac atgttcgtca tgtttatccc 1999501 tcctcacatg ttcaaaacga atctgacagg caaacacggc atcaatgata aaatgcgccg 1999561 tcatcggaac aaataagttg ccggtccatt catacatcag accgagcaaa aagctgattg 1999621 ctgtcaccat aataaataac agccattttg acaaataccg aaagtgcaga gcggcaaata 1999681 taaggctggc cgtccataaa ccgatatgag tctgcagcac tcctctgaat aacatttctt 1999741 ccgcgaaagc aatcagaagc gttaaaaata taatatgagg gattgacctc ttactgaata 1999801 tttttttatt gattccgccg tcatcatata aatgagacgg aaaccatttc attactgcca 1999861 tatcggctaa aataacaata acagctatag aaacaccata ccagatgatt cgcatatcgc 1999921 gaatgtccca gagctttaat acgtcccgta catcctcaaa aaagaacagt cctgctgcag 1999981 cagcggcaaa gatgatgagt agctgcgtca aatataactg cttcagcata tcatggtcag 2000041 tcatatgctg aatataatct ttttgctgtt tcagttcagc tcacctacag tctgcaagct 2000101 gaatatccgg tgcaattccg aactccagct gtctaatggc gccattttac tccgttcccc 2000161 tttttgttca tacaaggata aatcaaaacc gcaatgtgaa cagcacggga ggtttccgtc 2000221 atcaggctcg tatgattcat caaagtaggt taacagtgcc tgccttaaac agccgtcacg 2000281 ctgaagcaaa aatgatacac ggtgcatttt ttccagcttc agctccatgc gatatgaaat 2000341 ttctttcttc atcagttcaa ctgatgtttt tccctgcata aagagatgaa tcatcatacg 2000401 ggcctgtgtc tctccgacgc catactgaag taatacgtca cgcagccttc tctcatcccg 2000461 ctcctccgtc ttctctagca cacggattac gtcggcgatt tcttcagctg tgacactctc 2000521 catctggata atttgttcct gcaattcaaa atcccctggc gcccgcagca aaatgctgac 2000581 actcggcttt ccgtcgcgtc ccgctctgcc gatttcctgc ataaaagctt ctgccgtctg 2000641 cgggagatga aaatgaatca catatctgat atcaggttta tcgacaccca ttccaaacgc 2000701 attcgtacaa catatcacat caagctggtt atgaataaac tgctgctgaa ttaaaatcct 2000761 gtcccctgac tccaaaccgc catggtaaaa gtcggctctg ctgctcgttt tgcttttaat 2000821 ttcacccgct aattccttag cccatttccg tgttggacaa taaacaattc ccggaccttg 2000881 caggttttca accagctgaa tgaccctatc tattttttcg gcagtatccg ccgcattttc 2000941 aaccctcagt gcgatgtttg ggcggttgac tgagttgaga tggcgtacag catgctgcag 2001001 ctccagcagg ttcatgacat cttgcagcgt ttcctttgta gccgtggcgg tcaatgccag 2001061 aacgggtggg tgtccaagtt tttttctcag ctgtccgagc tttgaataat caggcctgaa 2001121 gtcgtgtccc cattcagaaa tacaatgcgc ttcgtcaata acaaataggc taatcggaac 2001181 gcttttcaat ttttccaata catatggaga ctgtaaagct tcaggagaca agtacaaaaa 2001241 tttatatcga tgaatatgtt ctaaaacaaa ttgtctttcc tgcctgttaa gcatgctgtt 2001301 caaagctgca gcacgctttt ccccccgggc tttgagctgc tgcacctgat cctccattaa 2001361 agaaagcagt ggagaaacga ttaataccat gccatcaagc atataaccag gcagctggta 2001421 gcaaagcgat ttccctcccc cagtcgggag cattgcaatg gtatccttcc cgctgagtat 2001481 gctttcaata atgtcctgct gccctttttt aaaggaagta aaaccaaaaa actgatataa 2001541 cgtttgctgt aatttagtca tattgctgca cctgctttgt caatgccagt ctgatttgaa 2001601 agtagctgaa ccgctgttcc agcccgtcgc gaatttgttt gattttattc gtccgcatcc 2001661 gtttggcaaa ctctgcgatt tgaagctggt cttctgctga tacatagtca ttaatcataa 2001721 acgcaggctc atggagagaa atctcgacaa tgtggtcttc aatcgtcgct gttttcagct 2001781 ttctgatttc agcaattcgc tgtatcggaa acccttgttt gaccatctgc catgttttcc 2001841 tcgtcgactc tgtcagggca ttatctaagt gcacatcaga aaggagatcc tttaacaaag 2001901 catcttcaca ctccggaaga gaatgaataa aataatgtac cgaagcccaa aacatgatat 2001961 agacatacca ttcgtcttct ttcagcgtat cagcaagctg cctgctcgta taaccgatcc 2002021 gatggtgcga ggttaaggag tagacaaaaa tttgcgctgc tttgttttca atctttttca 2002081 aatgcgcctc aagcatggca aaaaggcttt ttgccatctc tatatgatcc gtatgccggg 2002141 acaggtattt ctttacccag tgaagtgtct tatgatcctt tgtgacaggg atatactgcc 2002201 tgctcccttg ctgtttatgg gataggacct gcacaagcag cgaaagcctt ttccaaagca 2002261 cgccggcagc ctgctgataa tgagcgccgt gacaatgaac gggccaaggc cgctcgctaa 2002321 gggcatgtct caaaactgct gcgccgctgg ctgtcacttt gtatgtatct gattcagaca 2002381 ttggcgcgag atatgaatgc ttttcaagct tgtcaagcga cgcagaaata tcgcttctcg 2002441 aacattttgc cgccattcca aagtattttg cagtctgaaa taagccggca tcttgaatgg 2002501 tctgtgacga tctcttgcct ttgaataggt gaaaaacagc gcttcccgac cgttccccgt 2002561 ttattttgca aagacaatcg agaaccataa tatcgaagta atttaatgac aacctatcca 2002621 cctacattct tcctgacaaa aatcgttgat ttgctctttt tattttaaca gatttcaaac 2002681 agaaatcgac gtttaaagtc atcattaagg gggatgttat gtagataacc ccttatgtga 2002741 taagcattct caatcatttt tctgttgaaa tgtggcagca acatcattac aataagtaag 2002801 aggaataggt gttaaattga ttaaatataa agattgatcc atttgttcca ccaagaacaa 2002861 tctgggaggt tttattcatg gcaaagtaca caatcgtaga caaagataca tgtattgcat 2002921 gcggcgcttg cggagctgct gcaccagaca tttacgatta cgatgatgaa ggcatcgcgt 2002981 tcgtaacgct tgatgaaaac aaaggtgttg tcgaagttcc tgaggtactg gaagaagata 2003041 tgattgacgc atttgaagga tgccctactg attccatcaa agtggcggat gagccatttg 2003101 aaggcgaccc gcttaaattt gaatagaagt aactaaaaaa agctcccgaa cgggagcttt 2003161 tttatttaat ggatatgtgc acttcgctgc tgctcaatcc atggcttaag cttgataaaa 2003221 attagtgaga atacaaccgt aattacaata ccttttatca tgttaaacgg caggatacct 2003281 gcgacgactg ctgtttttag cgcgctgtcg gataatgccg gtgaatgtaa aaaccacgtg 2003341 tatgccggaa gaatcagaac ataatttaaa atactcatta aaatggtcat cgctgcagtt 2003401 cccaaaagca ggctgacagc caagcccttt gctgagttga gttttttaaa taagaaagca 2003461 gtcggtaata taaagagtgt tcctgcaata aaattcgcaa cttgccctac aggaactccg 2003521 gccatgcttc cctgaatgat atactgaaga acatttttta tcgcttctac ggcaataccc 2003581 gccaaaggtc cgtaaatcag aatggcaata attgcgggaa cgtcgctaaa atcgattttt 2003641 aaataatccg gaagacccgg aaacgggaaa tttaacagca tcaaaacaaa tgcaatgctg 2003701 ctcagcatgc tgaccacaac taattttttt actttcactt cattctctcc ttttcgatca 2003761 catcttactc gaaaacggaa aggttctttt ccagccaata aaaaaaccgc ttcatatata 2003821 aaagcggggt ttcgaaaatt aggctaggca aagaaacgtt tgaaaaattc aatttcaaaa 2003881 cgcttatgaa cctccatctt ctcccatcca gactgtactg tcggctccgg aatctcaccg 2003941 aatcctgctg taaagacagc tcgcgggctt agagccattg gctcatcacc gccggtaggg 2004001 aatttcaccc tgccccgaag attgatcata tgaaatttaa ttacattata aacgataact 2004061 ggttggctgt atagagaatt gcttcaaatt aaatatatta cctgcaagct gtcagatcat 2004121 tgatttatta ggctttactt ttatccttta ctgcgtcaat acacgttgac actcttttga 2004181 gaatatgtta aattatcaga tatttagttt gtcaatttag gaggaaatct aacgatgttt 2004241 cgagtattgg tctcagacaa aatgagcaac gacggtttac agccacttat tgaatcagac 2004301 tttattgaaa tcgttcaaaa aaacgtagca gatgcagaag atgaattaca tacttttgat 2004361 gctcttttgg tgcgaagcgc gacaaaagta acagaagacc ttttcaacaa aatgacttct 2004421 ttaaaaattg tcggaagagc cggtgtcggt gtcgataata tcgatattga tgaggctacg 2004481 aaacacgggg taatcgtgat caatgctccg aacggcaaca ccatttcgac agctgagcat 2004541 acatttgcaa tgatctcttc tttaatgaga cacattccgc aggctaatat ctcagtgaaa 2004601 tccagagagt ggaaccgcac agcttatgtc ggttcagagc tttatggaaa aacgcttggt 2004661 attgtaggat taggccgaat cggaagtgaa attgcacagc gtgcgagagc gttcggtatg 2004721 actgtgcacg tttttgatcc tttcttaacg gaagaaagag cgaaaaaaat cggcgtaaac 2004781 agccgtacat ttgaagaagt gcttgaaagt gcggatatca ttaccgttca cacgccttta 2004841 acaaaagaaa caaaaggctt attgaataaa gaaacgattg caaaaacgaa aaaaggcgtt 2004901 cgcttaatta actgtgcgcg aggcggaatt atcgatgaag cagcacttct cgaagctttg 2004961 gaaaacgggc atgttgcggg agcagcgctt gacgttttcg aagtcgaacc gccagttgac 2005021 aacaaacttg ttgatcatcc attagtcatt gccactcctc acttgggagc atcaacgaaa 2005081 gaagcacagc tcaatgtcgc cgcccaagtg tcagaagaag ttctgcagtt cgcaaaaggc 2005141 ctgcctgtca tgtcagctat caacctgcct gccatgacaa aagatgaatt tgctaaaatt 2005201 aagccttacc atcaaattgc aggaaaaatt ggcagccttg tatcacagtg catgaaagaa 2005261 ccagtacagg atgttgccat tcaatatgaa ggcacaattg ctaaacttga aacatcgttc 2005321 attacaaaag cccttctgtc aggcttttta aaaccgcgcg tagactctac tgttaatgag 2005381 gtcaatgccg ggggtgtcgc aaaagaacgc ggcattagct tcagtgaaaa aatttcctct 2005441 tctgaatctg gatacgataa ctgcatcagc gtaaaagtga caggagaccg cagcaccttt 2005501 actgtaacgg ctacgtatat tcctcatttc ggagaacgaa ttgtcgagat caatggattt 2005561 aatattgatt tttatccgac tggtcacttg gtgtatatcc agcatcaaga tacaacaggt 2005621 gtcatcggcc gagtaggacg tattctcgga gataatgata ttaacattgc aactatgcag 2005681 gttggccgta aggaaaaagg cggagaagcc atcatgatgc tttcctttga cagacatctg 2005741 gaagataaaa ttgtgaaaga actaacaaat gtccctgata ttgtgtctgt gaagctcatt 2005801 gatctgccat aattaaaaaa actcaagcta tatagcttga gtttttttat tgttctatcc 2005861 ccgtgtgttt ttatgcaaaa tatctaagac actccttagc tcagaaacag gaatttggcc 2005921 tggtgcggac gcctcttctc cagctccaaa agtacaagcc gatccaaaaa cctcaccgct 2005981 cagcctgctg atgagccctg ttgcagccat tgacattgta ataatggggc ggtctgcata 2006041 tattgttttc attgtatacg tcgcatcaag cagtgttagg agatctccag tatcattcgg 2006101 catgacagcc atttttggaa tatgcgcgcc taagtcctgc atttttcgaa gtctggaaat 2006161 aatttcatct tttacaggtg ttttttcaaa gtcgtgattt gacatcacca catagacgtt 2006221 gttttcttcc gccagcgata ctaacgcttt tacatttgca tctcctgaaa ataattcgat 2006281 gtctatcaga tcgatgtctt ttgtttggat tgccgattcc agcaaagcaa gataggagct 2006341 ttcgtccatc tccatgctcc cgccctcttt gtgggttctg aatgtaaata gaaatagctt 2006401 gtcttctaaa gatttacgaa gcttagaaat gagctttgtg accgcttctc tgtcattcgc 2006461 tttttcaaat acgtcgactc tccattcaac aatgtccgga ttcagtaatt ttactgcctc 2006521 tgcttcattc agaatttgtt tttccgtctt tcccatcagc ggaatgatga ttttcggcat 2006581 cccttccccg atggaaactc ctttaatcgt taacacgttc actcgtctca aatcctttca 2006641 atctttacct tgttttatta tacacgtaca actttttttt gaaaatttct attatatgaa 2006701 tagcaactaa aaaagagcct taaagggctc tttttagttt aaggaaatcg gatttggagc 2006761 agctggcacc ggaattgcat ctgatatgtc atatttgccg atttttttcg ttctggtttc 2006821 cgtaaaggtc acttctgtga agccaaactc ttttgcagtc aaaagtagtc cctcaatcat 2006881 taaaataccg gcaatagaat catcaacttc tgactccttt gaaaagcgga tatataagtg 2006941 tttctgtttc ttcgttacag attggacagc acccgcttga ataagaggtg tcgtatcttc 2007001 ttggctgctc gattccattt ccttaatcgc ttcttttact gtatcaaaag aatgatttga 2007061 cggaacgaga aagtcttgtc cttgtttatt ttggtacaag tagtaggatc gttttgactg 2007121 tttgggaatc gaaatttccg taaaagtgcc atatgagcca atccgaaccc cagtctcatt 2007181 ttgatccgat aaaaatttga ctttttcata aggactccat tttaaggatt ctttaagcaa 2007241 tttttttaac agtgtatcat cttttataga aaatgccgta gctggctgat ggactcgtat 2007301 acttaattcc ttctgctttg gtttttcctt tatttctact tcatctatga aggttggaat 2007361 tgtaatggca tgatcaagga tgcccaattc actactttca aacagcatat cctggatcgt 2007421 ttggtctgca tttgtttttt gaatgctgac gggtatgatt gcagatgtat cggcatcagc 2007481 aaccgctaca gtgatgtaat tgtcttgttc cttttcagga acgacaaacg atgtctgatc 2007541 caaggacgat gcagcttttg ggctgtcttc tgtctcagtt ttcgttactg cgttctcttg 2007601 ggacgcttct ttttgttgag gctgtgcctg atcaaagaaa tgaggagaaa taatgaaggc 2007661 gatataaacc gcaattgcag cggcacacgc ggggccaatc cacctgacag cgggcttatt 2007721 tttacgcttt gccatcgtca gccgcttgta aatatcctga ggcgaacgat ggtctttaac 2007781 tgccggaagt tgacttaaca actcctttat ctgttcttcg ttccattctg acttcatcat 2007841 ccattagctc ctccctcaaa agctccatat gtttccgaag tactttgagc cctctgtgtt 2007901 gggtcgtttt tactttgctt tccgagaagc gcagagcctt ggctgtttcc tgtattgaat 2007961 atccctgaat aaaccgcaag ataatcacag ctctttgatc gattgtacat tgatcaagcg 2008021 cagcataaat ttcccggaca ttttcatgtt gaaccgcaag ttcgtccggc agcaattgct 2008081 gatccctgac atcctgtgta tcccagtcaa atgtaccgag tatacgctgt ctgattgttt 2008141 gctgtttacg gaaccagtct atcgcaacat ggcgtgcgat agacaaaagc catgtttttt 2008201 cactgcttct tccttcaaac gtatgataag aatttaatac ccggatataa acctcttgaa 2008261 gaaggtcttc tgtctggttt ttatccttta ccatataaaa taaaaattgg tacaaatctt 2008321 gatgatatgt atcatataat aattgaaagg tttcttccat ttgaaacccc tccgttcact 2008381 tttttgtcgt atgaatagct tgaaaagtta cattacaact atattacgag taactggaat 2008441 ttggaaggga atttatatta acatatcctt aaattttatt aatgttggct attaaaaaaa 2008501 cacccgctca gtcagcgggt gtttcttatg gaacaagatt cttcggcaaa ttcagactcg 2008561 attttaccgt tttgtcggaa tataaaaaga aaatgttgtt cctttatcta ttcggctgtg 2008621 cacagtaatt gatccgttgt gggcttccac gatattttta acgatagcca gccctaaccc 2008681 ggttcctgct ctgccccttg tccgcgcttt atctgcctta taaaaccgct caaagataaa 2008741 tggcagatct tcttccggta tgccagaccc ggagtctttg atatcaattt tcaatccatc 2008801 cttcacagaa tggactgaaa tggagacact gccgccggct gaagtatgcc gcagcgcgtt 2008861 atcaatcaaa ttggtaaata cctgctccat cttgtcttca tcaaacataa attcctcttc 2008921 tgtgagagaa atgtcatgat ctaaagcaat atttttttct ttcgcaacac cggaaaactt 2008981 ccgaatgatc ttttctaaaa actcattcac attgattttt tcataatgta agcctgtatg 2009041 gcctgattcc attcgggcta aatcaagcaa atcattaact aaacggccca ttcggagcga 2009101 ttcgtcataa atgatttggg caatttcttt ccggtcttct tcagagcttg caatgtcatc 2009161 gacaattgct tcactgtatc cctgaagcat ggagatcggt gttctcagct catgactgac 2009221 atttgcgata aagtcctccc gcagcttatc aaggcggcgt tcttctgtca tgtcacgcag 2009281 tacggcaacc gctcctctga cgtgcgattc cgcataaagc ggcgacatca aaagcaccca 2009341 tgatctgcct tgaagcgtca tctcaatcat ttgttctttt tcagtgctga cagcgttttg 2009401 aaacagctct tttgcttcag gcggaagatt gtcgccttct ttgatattca tgttctgttc 2009461 ataataccaa gcctgaagaa aacgttcagc cggcgggttg gtcacaagaa tcgtaccgtc 2009521 aatattaatg gtaataaccc cgtcagccat actgctcaaa atgttagaaa gctgctcttt 2009581 ttcttgattg agcgcattga tatgaaagtt aagctgccgg cccatttgat taaaagcggt 2009641 cgccagttca ccgatttcat cctgagttaa aatcgggatt tttgtatcga acttgccctt 2009701 cgccaaatcc tgcgcgcctt ctctcatttt tcggagaggg tacgtgaccc tgcttgataa 2009761 aaagaatgcg aaaaatgtgg tcagcacaat cgcaattcca gcggcaagaa aaatatagcg 2009821 ggtcgtatgt tttgttgtat ctttaacggc aagcaaagac tgggataaaa agaccatgcc 2009881 tttctttccg tctttttcat acgggacacc tacaatcagg cgttcattat ccgtgtctgt 2009941 atcgctcagt cccgtccgtt tgcttacttt tttatggtct ttgagagctt tatttaagtc 2010001 tttgtcatgc tgtatttgct caaccgtaat agacgacagg cgatttttat cattcggaga 2010061 ataccagtgg ttcttctcat cctggatgat ggcaatgctt gttaagttat cagcgagttc 2010121 ccaagtgatt gaccttgcca gtgcctggtc ctcgtgattt tctaggatga cagcaacttt 2010181 attcgcaagc tgtgttaaat cattctcagc ttcttccaca tggtagtttt caataaactc 2010241 cagcaaaaga accgttaaaa tgaacaatac gatcaagacg agtgaaagga tcgtaaacca 2010301 cagcttgcct actacgcttt tccaaaattt cattcagcgc cgacctcaaa tttataacct 2010361 acaccccata cggtgacaat ttttttcgca gcttccggag ataccttgtt cagcttctct 2010421 ctcaagcgtt tgacgtgagt gtccactgtc cgtaaatcac caaaaaactc atattgccac 2010481 acttctttca gaagcttttc ccgatcatac accttgtcag gcgttttcgc taagaaatat 2010541 agaagctcat actcttttgg cgtcaggctc acttctgttc catcagctgt tacgcggtga 2010601 gcatcatggt ctattgacag atgtgaaaac acgagcacat ttttcgtcgg tgtattggca 2010661 ttgaaataag aggtttggga tgctcttctc aaaagggcct ttacacgcag cacgacttct 2010721 ctcgggctga acggcttaac aatataatca tctgttcccg cttcaaaccc ctgcacccgg 2010781 tttgcttctt ctccttttgc ggtcagcata ataatgggtg tcgctttttt ttcacgaatt 2010841 tgccggcaca cttcaattcc atcagtcccc ggcatcatca gatcaagcaa aattaagtca 2010901 taattggctt caagcccttt ggcaatggct tcatcaccat tttcagcttc atctatagca 2010961 taattttcac gttcaagata cattcttaaa aggcggcgaa ttctggcttc gtcatcaact 2011021 actaatattt ttgtttcgtt cgtttggtcc atgttttccc cctgctttcc ttctgttact 2011081 ttcattttat caaatcgtga gaaagtttga gaactgtgtc gctttcaaag gactatgcat 2011141 aagaatgaag tccggcaagc acaagattta cgaatattaa attaaacata ataatagcaa 2011201 aaccgattac ggccagccat gctgacttct caccgtgcca gcctcttgac agtcttaaat 2011261 gcaagtaagc ggcatagaac aaaaatgtga tcagcgccca tacttcctta gggtcccagc 2011321 cccaaaatct ggtccacgcg agctgagccc aaatcattgc aaagatcagc gcgccgagtg 2011381 taaagatcgg aaatccgatt gatacggccc tgtacccaac ctcatccacc agatcaagat 2011441 tgacgttttt caccagcgga tgtaatagag cgctgattct ttttctgatg atcagacgga 2011501 gagccccata caacacaaga cctgctccaa atgaccaaat gacagtgttc acttttctgc 2011561 ctgagaaaag cgcgggaaga tcaacaagcg gttccattct tccttcggtc aaaagctctc 2011621 cctgatgcgg accgacaagc gcgggcattt cgtacaccat cacgcttttt tctttacttt 2011681 tgtccaccca gttaaactcc gcttcatagc ctgcaagacg aaatgccgat gtgattgcaa 2011741 taaaggcgac ggttgtgacc aggataaaca taatcgcttc aagccagaag gtctttttgc 2011801 ttggctttgt ctggtctaca tgcttcaaaa gaaagatgac accagcgaca aagctgatgg 2011861 caagtatagc ttgcccaagc gcggccgttg ttacgtgaat atacagccag ttactttgga 2011921 gcgaaggaat taaaggcgag atatctgtcg gaaacatgct ggcgtaggca atcagcaata 2011981 aagcaattga cagcgtaaac aggcctaatg aaggcaatct atagagaaaa taaagaatga 2012041 taaacgccaa aacaagcatc atgccaaaag cggtggtgaa ttcaaacata ttgctgacag 2012101 gcgcatggcc gcttgcagcc caccttgtga tgaaatatcc taggtggcag aaaaaaccga 2012161 caatagaaag ggtgattcca atgttggccc atcggtttgg cctgcccttt ttatctttat 2012221 tcccgcgtat ggccccgccg aagattggga cagcgattaa atacacaaga aaggccgcat 2012281 aaagaaaatt tccgctcagc tctgccatga catcactccc ttttcgccta tttctgtgtt 2012341 ttgattaatt ctttttggtc caccggttca gtcagtccgg aatcagccaa tataaatgct 2012401 aaatccttct tcaggccaaa ccagttttta ttggtatgcc ctgctaccat aactgcaccg 2012461 tcctgtgagt gcagccaaat tcttcgatgc tgccagtaca taccttgaat gacaccgatc 2012521 ataaaaatgg ctccgccgac agcaagcacc cagagtgtca gatcctttct gactgtaagt 2012581 ccagtaatgt ttttcgtttc gacatggtca aatttcagct tgtatttatt attgcctgat 2012641 ccttcgatgg tttcttggat ggcgacaaag ctcttttcgc ctttcggttt gtccggcgtt 2012701 atgatattaa agacaaaagc cggattgtta gggatctttg tttttgtgct cggctctccg 2012761 tcctgattaa aatagaagtc aggcaggtag ctggcgattt ccaccttgta accgttacca 2012821 agatcataga ctgaatctgg atccagaagg ttgatcttca ggctcccaaa ggattttttt 2012881 gtttttttat caatcagctg gaacaccatt tggtcaagct gattctcttt gtaatccacc 2012941 tggtaaacgg aaaaagaatc aaaacgcagc ggctgattga cacggatgtc ttcttctgtt 2013001 actttttcca gcttcggctt ctcgccataa acaatttttc cttctctctt gtagagtacg 2013061 gcatcagttt gaaagttctt tgccactcta ccgtccccga ctctgtcaat ggcatctgca 2013121 aatacctttt tttccgtttt gctgttatag gtctctacgc tgaattgatt gtttttcaaa 2013181 taatattttc cgtctgtacc cggaattgct gcggtttcgc cttctctgac ccaaagcgtc 2013241 tcatcgacgt acatgccagg cacaaatctc agcatcgcac caatcagaaa gatgatcaat 2013301 ccaatgtggt tgacatacgg gccccagcgg gaaaagcgtc ctttttcagc aagaatgctg 2013361 ccctcttttt ctctgattct ataatgtttt ttctttaata gagtaactat cttttctttc 2013421 gattccccgt tcagtacagt aactgtttca ctgaacaagc gctgccttct taaaaaggcc 2013481 gggctccttc tgacaccttg gttttttaac gctctataca acggaatgac ccgatcaagg 2013541 ctgcaaatca cgagtgaaat gccgatcgag gcaatgagca gcaaatacca ccaagaacca 2013601 tataaatgat gaaacccgag caaataataa agctggccaa acgtgccgta ctgctccttg 2013661 taataagtat cagcctgtgc gcccggaggc agataggctt cctggggaaa aatggtgccg 2013721 aacgctgatg cggcaagggt tatgacgata agccatattc ccaccttaac cgaggaaaag 2013781 aaattccaaa ttttgtcgat gatcgttttg ttataggttt gcgaacgtct tgcgcttccg 2013841 tcatatctca tatcagcgag cggaggttga gtttcctgaa gagctcttcc gcacgattcg 2013901 cataaaacgg ttccgaccgg gtttatatgt ccgcattcac atttgacttg cttcatcccg 2013961 aagtctctcc gggttttatg agattcatat aatcgtgtat catgctttct gtcatagtgc 2014021 cggtcaccac cttgacaact tttccttccg gattgatcaa aaaggttgtc ggaagcggag 2014081 atacgtcata ggcatcaagc acttggcgat ctgtatccag aacaaccggg aaattgactc 2014141 cgtaggattt cataaaatta tgtactgcta tctttgactc cccaacattt acagcgacaa 2014201 tttcaacacc ttggctttta aaatgcttat attggtttgc catataagga aactcttttt 2014261 tgcacggttc acaccatgta ccccagaaat tcaaaaaaac acctttccct tttaagtcac 2014321 tgagctcgat acgtttccca ttcgtatcct ctaggacaaa attcggtgcg tcggaccctt 2014381 cggatatact ctctttgccg gcaaatacag cgttgtaaat ggtatagccg agtgcgcaga 2014441 ttaaaacgag aaggatgccg gtccgaatga ataaacgcct ttttttcttc attgtccact 2014501 gcccccttcc ccctattgca gatccattca attatatcat tgcacgttca tttcacattt 2014561 cttacttttt gaaggttatg tgaaatttag aaagcgtttt taccgtgatc cgccagtgct 2014621 ctgagccttt ttacttcgtg aggcgtaagc tctctggcat cgcccgtgtg caggcctcgc 2014681 aggtttaaaa acgcgtattc ctcacgcttc agcttgatta cctcatgtcc gatcgcttca 2014741 aacatgcggc gcacttgtct gttgcgtccc tcatggatcg tcagctgaat aatgcttgtc 2014801 tgctttttct tatccaaaga cagcagcttc gctttagcag gcgctgtttt gccttcctcc 2014861 agcctaattc cgcgctccag ctttctgagc agctctttag gcgggattcc tttcaccttc 2014921 gccacgtatg ttttgtctat ttcatactta ggatgcatta gcttattggc gaattcgccg 2014981 tcattggtta aaagcaaaag accgctcgta tcatagtcca gacgcccaat cggataaatg 2015041 cgctgcggaa tatttttaaa aaagtccgtc accactttgc gtcctttatc atcttgcgct 2015101 gcggaaataa cgcctcttgg tttatataag agaaagtaaa ccggctcttc gcgttcaacc 2015161 tttaacccgt ttacctcaat ctgatcagaa ccggtgacct taacacctag ctctgttact 2015221 actttgccat tcacctttac ttttccttct ttaatcagct cttctgcctt tctgcgcgac 2015281 gcaactccgg catgagcaat cactttttgc agtctttcca tgtctttcac ctcaagtatt 2015341 atcttacttt tttcaacctt aacaaacaag ctttttcaaa ttcctatgcc aaatctaaaa 2015401 aaaacgccgt tttcaggcgc tcccaaataa taacgtaacg atgatgatag atgcaactac 2015461 gccgattaaa tctgcaagaa gtcccacctt taatgcatca cccatttttt taatgccgac 2015521 tgctccgaaa tacacagtca gtacgtaaag cgttgtatct gtagatccct gcatgacgga 2015581 agccagcctg ccgataaagg aatcgggccc gtatactgca attaaatcgg tcgtcattcc 2015641 aagtgcggcc gtaccggaga tcgggcggat cagagcaagc ggcactactt cagcagggat 2015701 gccgatagcg gagaaagccg gttttaaaag atccattata aaatcaagcg cgcctgatga 2015761 tctgaaaaca gttatagcga caagcattcc gactaaatag gggataatgg aaaaggcaat 2015821 ttctatcccc tctttcccgc cttcgacaaa cgattcatat gtcggaacct ttttgatcgt 2015881 tccataaaga agaattccgg caataatgat tggaatcatg gctaaagaca gccagttgat 2015941 gatttccatc cgctcacctt cccttctttt tgcggcggta ataaaaatac cgatcaatga 2016001 taatggcacc gattccggaa ataagcgttg ccaaaatgct tggcccgacg atatctgtcg 2016061 gcgttttgga ggaataagcc attcggacag cgatcaccgt tgtcgggatg agtgtgatgc 2016121 aggacgtatt aacagctaaa aaagtaatca tcgaccggct tgcttccgat cggtttccgt 2016181 tcagcttttt catttgttcc attgctttaa tgccaagcgg agttgctgca tttccgaggc 2016241 cgaagaaatt cgccataaga ttagataaaa tatagcccat cgccgggtga tccggcggta 2016301 tatcagggaa cagtttagat ataaaaggtc tgcacatccg gctgaaaata tccaaaagcc 2016361 ctgactgctc ggcgattttc attaagccaa gccagaaaac aagcacgctc atcaatccaa 2016421 atgagatcgt aatcgcttct ttcgcaccct taaacacggc ttcatttaca tcttgcagag 2016481 ttccgttgca catcgcaaaa acgagtccga tcacggttaa actgacccaa attatattga 2016541 ccattttgct ccgcctgccg cattcagaaa gattgattta aacgtttcaa aaaattgttt 2016601 cttcggtttt tgatgccgct cattttcata atagatcggc acttttgcga tggttgcatc 2016661 gttgaacatg atctccatgt gccctacgat gtcagggatt ttcgaggcat ctttttccca 2016721 tgcttttttc ggcttgagca gtgtggtatt aatttttaca ttttcttttt cctcttcggt 2016781 cagcaaatag gtgatatcac gtttgataaa agccttcgat tcataaaatg tgcctttcag 2016841 ctttggaata tccccttttt ttgcaattaa ataggtttga taatgctcaa acacatagtt 2016901 aaacatcttc atatggtcat cccaatcatt agggtcatta atggtgacgg ctatcaggtc 2016961 aatgccgtcc tttgaagccg tagagaccag tgtccgtttt gcaagttttg tatagcctgt 2017021 ttttcctcct gtgctgtacg gataaagcat ggtcagcagt ttgtttttgt ttttccatac 2017081 gctttccatc gtttccgctt tgtatatttt tgtgcctgaa atcttttgat agtctttcag 2017141 cttcatagca tacttagtta aaatggccat gtcataggct gttgaataat gattttcatg 2017201 gtcgtccaat ccgtgcgggt tttgaaaacg ggtgtttttc ataccaagct gctcggcttt 2017261 ttgattcatc atataaacaa acccatcgag gctcccaccg acatgctcag caatcgcgac 2017321 agcggcatcg tttcctgatc ttagcatcag gccatacaca agatctttca gcttcacttt 2017381 ttgaccttct gttaaataaa tggcggagcc ttctgttctg acagcatttg ccgaaaccgt 2017441 cactgtttga tccattttgc cggattcgat ggcgaggacg gcggtcataa tttttgtgat 2017501 gctcgcgatc cgcctttttt gatgctcatc cttggcatat aacactctgc ctgacgcacc 2017561 gtcaataatg atcgcgcttt ttgcactgac atctatagca gcatgtgctg tattcacatt 2017621 tacggttgca ataagaaaag aaatcatgat cacgaatact gcttttttga aaatgcgcat 2017681 gtttgctcac gtccttgtgg tggtttgtac aagtttatgc gcatgtccat cagttatgaa 2017741 taacaattat atttctggaa gcaaacataa aaaaactctc cctgaaaaag ggagagtaaa 2017801 cgttatctga ttggcgccat gcttgatccg gacgcttcgt aatgagccag ctcttccctc 2017861 atcttcagaa aggccgcgct caacggcaat aataattgct caagcgacgc aggaacagca 2017921 tgataaaact caattgcgct gaccccggta taagacgccc ggctattttc acaccacgtg 2017981 tcttttttcg gcataaagaa ctcttcaatg cattggtgat acacattata aagtgttttt 2018041 tccgctctgg cttcctgaaa aggctcctgc atcaggagac gacggcacgc ttctgcgcct 2018101 ccttcacaaa atactgccat tcttctcaga gtgctaagca catcacagca gtatcctttt 2018161 tcaataggca attcagcctg taaggactca agcgtcgttt gatttaggta atcgttcacg 2018221 gtattgacaa ccattgataa gaattcgcct gttttttgag tctgcgctcg cacaatcgaa 2018281 tgtcccattt cgtttggtat cttcccctca tgtatttgtc tctcacattt tgcttctttc 2018341 atgatagctt cttccttata tcttatgatg atgaaaaagc gcgattcatt aaacttctat 2018401 tttatatctt cgaaggtttg gttaaagttt tcaaaaaata aatctgcttc ttcttgaaga 2018461 acgtcttctt ccgcattttc aggcagcggc ggaagctcgt ccagcgtttt cagaccgaat 2018521 tgttcaagaa aagtcggcgt agtaccgtat aaaatggccc gccccggacc atcggcacgc 2018581 cctacttcac acaatagcgc cttcgcgaca agactgtgta aaatccgctc tgattttact 2018641 cctctgattt cttcaatttc tgctctcgta attggctgtt tgtatgaaac aatggccagt 2018701 acttctaaag atgcttgaga aaggcccttt gacggcactt caatcagttt tttcaagtaa 2018761 ggcgcaaagt cttttttggt agagagcatg tacgtatctg catactcaat aagttcaatc 2018821 cctcgtgtat ctccgcggta ttcgtccgcc acatccgcca tgatcgtgtt cagttcaggc 2018881 tcttcgattt caagcactgt taacagctgc ttttttgtaa gcccttcatc gcctgccgca 2018941 taaagaaggg cttccacaat agctttccaa ttcacgatat caagccccat gaatggattc 2019001 actccccgta atgtaaatat ctgaaaaatt gtgctcctgt tcaatgagga ccagctgatt 2019061 tttcatcagc tcaagaacag ctagaaaggt cactactaaa tgttcttttt gctcatatgg 2019121 aaacagatcc ataaagttaa ttctcgttcc tctagatttc aagctgtgca cgatttcgtt 2019181 cattctggct tcgattggta tgtcctgtct tgtaattgtt gtttccatcg gcctgtttat 2019241 ttttttgcgt ttcagcactt tttgaaaagc tccgatcata tcatagaccg tgacagagag 2019301 cttttgctca gactgtttta cttcttttgc atattcactc aaatcactcg gcggtttcgt 2019361 gaacgatttt tgtctttctt cttcccgttc ttttaaatcc ttcgccgcat ctttatattt 2019421 tcggtactca atcagctttt caatcagttc ctcccgcgga tcttcttctt caagtaattc 2019481 atcttcaaaa agctcctcct cttgcttcgg gagcagcatt ctgcttttaa tgctgagcag 2019541 cgtggcagcc ataaccaaat actcgctggc aatgtcgagc tcaagcacgc gcatcgtatg 2019601 tacatataat aaatattgtt cagtgatctt cgccacaggt atatcatata tgtcaatttc 2019661 aagacgattg attaaatgaa gcagcaggtc caatgggccc tcaaacgtat caattttcac 2019721 ttgatattct tccatcatct caccattttc aagtatcact ctcattgccg gaaaaactgg 2019781 ctaccctata gtataagcca ccaaaaagct ctcgtccaat actatttcat atcctgtttt 2019841 gaaggagttt gtacagaata ttcaaaacac aagaggtgtt tgctcggagc gcagaagcgg 2019901 gagaaaaagc ctttgcttct ggttttcctt tctaagaagc actagaggcc gggcgttctt 2019961 ttttcctttt atcccttcta tggtacacta aaagcacatt aaaggaggaa gcaccttgta 2020021 tccgaaagct tatatagatt atctcgttga gtttcatgcg acacgggatt attttgaatg 2020081 ccatgaaata ttagaagaat attggaagga agatccgcca aagaaacgaa aacgctattg 2020141 ggtgggcttt attcagcttg cagtggcttt atatcatcac agaaggcaga atacagccgg 2020201 ggcaaaaaga ctgatggcga acagcatccg gattcttcaa gcagaacacc gggcagtcga 2020261 agacttaggg cttgatcatg gccgtttgct cgaacttatg caatcggttt acgaacaaat 2020321 cgaaaccgtc tctgcctata aaagcattat actgccaatc aaagatgaga aactggagga 2020381 agcatgcagg atcgaatgca ggaaaaaaaa gtatacatgg gggcagccca gtgcactcag 2020441 caacatattt cttatcgaca aacaccgttt gcgggatcgg actgacgtca tccgtgaacg 2020501 tgaaaaagaa atagaacgca gaaaaaaaag cagagactga tcacagcctc tgcttaatta 2020561 ttgtatgaaa tgtcttgatc ctgctgacct tgacaacgtt cgaaaaagct ctgcgttaat 2020621 tcatttggaa ccagtacttg cgttttgaat aaatgcttta aagcatccat catctgtttt 2020681 ccgattcctt gatggcgatg agaaggattc acactgatat gccggatctc aacctcagaa 2020741 tccttttttt cgactccgat tgctccgacg atatcctcgt cctctttcca aagaaagagc 2020801 tggcggtctg tatccgtttc gtagtcctta attgtctgct gaagctgctt aaggtctttt 2020861 tcattcggca taaacgaaag aagccccatc gcaatctttt caaacgattt tttataacga 2020921 attaacataa aaacccctct atatccaaaa tgtccagtct gctattaacg gatacgaata 2020981 ggtgatccgt tttctcacat tatatcattt tcgccatatt tttaaactgt tttcagcaaa 2021041 ttattcaaat gagcggttta aatttgccat ttcaatggca gaaacagcac aatctacacc 2021101 tttgttgccc gcttttgtgc cggcacgctc gatagcctgt tcgatgtttt cagttgttac 2021161 aattccaaag atgacaggta caccagtagt gtttgctgct tgcgcgatgc cttttgcagc 2021221 ttcattgcag acataatcgt aatgtgtcgt tgcgcctctg atgacagtgc ccaatgtgat 2021281 aatagcatca tatttttttg tttccgccat ttttttcgca gcaaacggta tttcaaatgc 2021341 gcctggaacc caagccacat caatgtcatt tgtgtctacg ccatgtctga gcagcgcatc 2021401 ttctgctccg ctcagcagct tgctcgtaat aaaatcatta aatcttccta ctacgattcc 2021461 gattttaaga cctgtaccaa ctaaatttcc ttgtatgata ttcatatgat tcccatcctt 2021521 ttttgtgata tttgtgatta gaaatgaagt aaatgaccta gcttgttcat tttggtttgc 2021581 aaatattttt tattgtgttc tttcgcctcc atttgaagcg gcactctttc tgaaatactg 2021641 agtccgtagc cttcaaggcc tgcgattttt cgcggattat tcgtcaaaag cttcatattc 2021701 cggacaccga ggtcgcgtaa aatttgtgct ccgatgccat agttgcgaag atccggcaag 2021761 aatccaagcg cctcattggc ttctacggtg tcatagcctt gttcctgaag cttataagct 2021821 tttaatttat tgattaaacc gatgcctcgt ccttcttggc gcaagtacag gagcactcca 2021881 cggccttctg cggcaatttg gttcagcgcg gcgtgcagct gcggtccgca atcacagcga 2021941 tgagagccaa acacgtcacc tgtgagacat tctgaatgca cccggaccaa taccggttct 2022001 tctccgaacg gcacatctcc catcacaaat gcgacatgct cttttccatc tacctcattt 2022061 gtgtatccat aaaccttaaa tgtcccaaaa tcagtaggca gcgtaatgtc aacttcacgc 2022121 tcgacaagtg ttgtcagatt gtaacggtat tgaatcaaat ccttaatggt gatcattttt 2022181 aattgatgct ttttcgcaat ttcaatgagc tcaggcactc tcgccatcgt tccgtcttca 2022241 ttcataattt cacaaatgac gccggctcct ggagatccgc aagcttcagc aagatcaaca 2022301 gcagcttctg tatggcccgc tcttttcagg acacctcctt ttttcgcaat cagtggaaaa 2022361 atgtgccccg gacgctgaaa atcagatggc acggatttgc tgtccagcaa tgcttgaacg 2022421 gtaaaagatc tttcttgagc gctgatacct gtcttcgttt cacgatggtc tatgcttacg 2022481 gtaaatgcag tgtggtgaga gtctgtatta tgctcaacca tagggtgaag atcaagcctg 2022541 tctgcgattt cctcactgag cggcgtgcag atcagtcctc tcccatgtgt cgccataaag 2022601 ttaatgactt ccggcgttgc atgctcggca agagccacaa agtctccttc attttctctg 2022661 tcttcatcat ctacaacgat gatgacttcg ccttttttta aagcgtccag tgcttcttct 2022721 atcggatgaa acatgcaaat cttcctctct aaaagccgtt ttcgcttaag aaggcttttg 2022781 taatggtttg ttgggtctta ttttcattgg ctttatgcaa aaatcgatac atatattttc 2022841 cgatcatatc gcattcgata ttcactttag agccgatcgt tttttctgaa aagatcgttt 2022901 cgctgatcgt atgcggtatt aaggagatcg tcactgtgtc ttctgtcagg ccgaatatgg 2022961 ttaagctcac gccatccaca gtaattgatc cctttaaaac caatgttttt gttaatgacg 2023021 ggtccatttt taaatcatag taaactgcgt tgcttttctc ttcaattcgt gtgatttccg 2023081 cagttccgtc gacatggcct gagacgaaat ggcctccgaa acggccgttt gccgccatcg 2023141 ctctttccag atttactttg cttccttttg ttaaatcatt cagtgacgta gctttgactg 2023201 tttcaggcat aacatccact gtgaattgat tttttgtaaa atcagtgaca gtcagacaaa 2023261 tgccgttcac tgcaatgctg tcgccaagat gaacatcctc taaaatcttt gagcatttaa 2023321 tagttaaggc cattgcatgc cctgcttttt tcatggattc gattgtgcct gtttcttcga 2023381 taattcctgt aaacatggtc accatcctat tcctttgtcg gttttgccgt cagtttgata 2023441 tcacggccga tttgggttat atcagtgaat tgtaataagg ggacatcttt cattgattga 2023501 aaaccttcac cggagattaa gctgggagca tgcgttcctc cgattagttt aggggcaaaa 2023561 tagaagatga tttcttgaaa acagccttct ttgacaaagc ttccgtgaac agctgaaccg 2023621 ccttccacat acaccgacat gatgccttct tccgctagga tcttcaaaac atcaggaatt 2023681 tgaatgcgct cggtttcaag tgtaaatatg ttcactccga aagctgaaag ccgttttttc 2023741 ttttcctcgt ctgcgcgtgc cgtcgtaaaa atccatgtcg gcgctatttg atcgcaaatc 2023801 actttagcgt cctcaggaat cgagagtacg gtatcaagta tgacccgaac cggctgtttt 2023861 gttacattcg gcagtctgca ggttaagctc ggattgtcgg ctttcactgt gccaactccg 2023921 actaaaatgc tttggtgtgt tttcctgtat tgctgagcat cctgtcttgc agcctctgac 2023981 gtgatccatt tgctgtcacc cgtgctggta gctatcttgc cgtcaaggct ggcagccgct 2024041 tttagcgtga cgtacggaag gcctgtcctc ataaagtgca gaaatttttc attcagcctc 2024101 tccgcctggt ctgccaggat gccttccctt acctcaatgc cagcttcttt catcatgctg 2024161 atccctcttc cagccacaag cggattagga tctctcatcg ccacgaacac tcttttgata 2024221 ccagagttga taatcaattc tgcacatggc ggtgtttttc cgtaatggct gcacggttcg 2024281 agtgtaacgt aaatgtcggc accctctgca tgtgctccag ccatatggat ggcatgaact 2024341 tctgcatgag cttcaccata ttttaaatgg gcgcccattc cgacaatttg tccgtccttt 2024401 acgacaacag cgccgacgag cggattggat tcggtctgtc cttcgccctg cttcgcaaga 2024461 tctaaggcca gcttcatata atactcttcc atttgtttcc ctcccctctt ttgttattta 2024521 ccgtcaaaaa agccccgaat ttataaaaaa ttcggggctt taggtatttt acgcaatagg 2024581 aaataacact atgcattttt aaacattttg catagcggct catcatcctt ctcccatcca 2024641 gactttcact gtcggcttca gcttaaactg aatccaccgc gtgcttatgc acacgggtca 2024701 cgggctctaa agcaaatgtg ctttactacc gccggtcggg atttccaccc tgccccgaag 2024761 gatacaatct ttattcattt gtccttattg gttattatag cgatcctttt taaagtacgc 2024821 aatgaaataa acttacaatt tgagaaaaac aaaacatcac ccttcgatcc gaaaggtgat 2024881 gttttttaat cattcacttt tgcaaccttg attaatccgt cgatccgctt tgatttgctg 2024941 aagtaagcct taatcttgtc accttctttt atatcagata aatcctgatt taattttttt 2025001 ccgttgaaga tgattttcgt tccgttttct gctactccat gatactctga gccgtcaatt 2025061 ttcgtcactt tatattcctg gatggtgtat tcctcttctt ccgaggacaa ggtttgtcca 2025121 attgctgtcg gaacatcctt cagctcaata tcatttatgt acatataacc gcctgcaagt 2025181 aaaagcaaaa gcactaacag aatggtaatc ttggttttta ttcttcccat ttctaaacct 2025241 ccagccaata tgaatctatt cattcatatg agttattcct ttttttcatg aataaaaaac 2025301 cgtaaattct cgtaaattat taatataacg atgcataacg ggaatatgtt tcacatttct 2025361 gcaaaaattt cttttctata gatatacgaa tttatgttct gtttttaggg gatgaccgta 2025421 aaaaagatat aaaaaaagca gccccaatgg gaagctgctt gatcctaatt tgttttgcgc 2025481 atttcgttaa acgggtagaa aacaaacttt gacgtacccg caatttgttt tttcgtgaag 2025541 aggccaaggc cgttacggct gtccatggaa ttgcgacgat tgtcacccat cacaaaatac 2025601 ttgttatcag gcactttaac cgggccgaaa tcatcggtca aatggtcaaa accgtcctgt 2025661 ttcgctctct ttttattagc cgccaaataa ggttcgtcca cctttttccc gttgatatag 2025721 agctggtcat ttttcatctc aaccgtatcg ccgggaaggc cgataatacg tttgacatag 2025781 tgaacatcat ctccgtttaa cacgacgatg tctcctctat caaactcgcc gatgtatttg 2025841 actgtcatat taacaaaaac cctttcacgg ttgtgaagtg taggatacat agagtcacca 2025901 tcaacgacat acggcgcaaa aataaagttg cggatgagca aagcaagaac gacagcaatc 2025961 acaattgctt ttgcccattc taatattgac tttttcttcg aaacattttc tgatttcaac 2026021 tgatttcctc caataaacaa cggtcttcaa tttatgttat cacgaatcga aaaaaaatcc 2026081 cattaggacc attgaagtga ttttacaaac tgttaatctt catcttctac ccacatcatg 2026141 cctatttttt cttgtcgatc ataactaggc ctgaaaatat tgaaagaaat gaatcgcata 2026201 attcagaagc gatggactca gaagaaagag agttctcata tgcaaaatct ttagatcgta 2026261 tataaagcat gaggttacgg gcagtttgtt catttactgc attccattga tctcccagtc 2026321 catgataccc atggcacttg acaaaacaat taacgtcatg aaggttactg gaatgtttgc 2026381 ggcaacctat ttcacaggtg ataaccgcac cccgtttttt gctttcataa tatgtttaaa 2026441 atcattcaag ctcgaaaaca tggatcagcc tccaaaaaat aaatccaata tattcccggc 2026501 agttgaagac tctttattat aaaactctga atatccgcag ttcttacagt aaaccactag 2026561 aaatcggtta tgctgcacgt caaacagctt tgataatccc gtgccggttg tagctatttc 2026621 tttttgtccg gcttcagtac taccgcattt tatacagcct ttgttgttca tatcgcgatc 2026681 tccttttcat tacatcacgt ttgtttgatt tattttacta caaaatatca atcccaatga 2026741 cccgtactac tttaaagttt acttaatttt gattacatac taattgggtt cgtttctcag 2026801 cttggtaaat cttctggaga aacggaaaag ctccatgacc aaaacattca aactcagcca 2026861 aacaccgccg aaggcgtaac ccgcagcaac atcactcgga tactgctcat aaagtacaca 2026921 cggctcagcc cgatgaggaa taaaacgata ataaacaaaa aaatgcaaca gtttgcagac 2026981 gcgtcttgtg agaatgacga acaaaaagat aagcacaaaa accaaaaatg acaaatgccg 2027041 ttaaagtctg ttcgctcggg aatggatata atacatgact ttccaaagga gcgtgaacag 2027101 gatgaaggga atgaaagagc cgtctgattc cctcttcata aagctcccca ccaatgacta 2027161 ggaaaaataa gaaagagagt tcgattttcc gatcttgccc tctgaatacc gtccaaaaaa 2027221 aagttagaac aataacggct aacagaacac ctctcgacgc aaaagctttc tgaattgcag 2027281 ctgggcccag tctatacccg atccaatacg acatgctcac tcccacagct ccccaatccg 2027341 gccgctaaca tgcttagcac ccagtttaac ttttcttgaa acacgagaac accggcaaac 2027401 tctcccggtc caagtaaagc tagaagctct aacatcaaga caataaacaa gacggcatat 2027461 ccgtactgtt cgagcaaccc cgtcaaaact tgcatgtgat tctccttaaa cttttttgtt 2027521 cttttatcat tcccaatcca ctttttgtat aatcagcaca attttatctt cagtcgtcca 2027581 acaacattgt ctatggcggg atcttctctc atacattctt ttttgacata ggaggagcaa 2027641 tagcatgaaa tgggaggaaa caaaagatac gcagggagtt tgccaaaatt ttgggcagtt 2027701 cgttctgcca ccgagtcagg tgtttgtttg cccacctcat cccttgtcaa ttccccattt 2027761 ttcccgtttg aggttcgaaa tggtaaagta tttcacttag tttcttacat gaagaggtaa 2027821 attctttgct caccgaacta ggatagcggc gtatggcgat ttctacattg cataaccact 2027881 ggttatttag tgagccgtga gcaatgtata tgcactttga gtcagcacag gatgatccta 2027941 ttacattcgc cagaaaagca gctgccgcat tcagagtagt taaaagaata gacagatatc 2028001 tgggcttccg gaagctttaa aggaggctct tttttcgagc atttttataa atcaataaaa 2028061 acaggcatct cctaaatatt tttgccgata agtttacgct aatcaactct agcactaata 2028121 catataaaaa atagaatgat atgaaaggag acttgatagt atgattgatt atcctattaa 2028181 tataaacaac gtttccggga acagtgtaat taacgtaggc ggcgctttta tgatcaggcc 2028241 tttaactttg tccaaatctg tgtttggctc cggaggttta aacacaggaa ttgtctttga 2028301 aaataacttt gtaagcaaag ctaaaatgat taatcatcaa tttactgatc aaaacgtcac 2028361 caaaactttt taatgtattc aatacacggg ggtcactaac taaacacctg gttttgccaa 2028421 ccgccatcag cattcggcgg ttttttattg aacatttttg gccaataaaa aaagcttcct 2028481 ctctaagagg aagccttttg cctgccgatt agccttctac acgaacttct ttcatgacat 2028541 cgccattaga catgtttttc gcgaattcta atccgcttgt tactttacca aatacagtgt 2028601 gaacaccgtt caaatgaggc tgtggctcat gaacgatgaa aaattggctg ccgccagtgt 2028661 cttttccggc atgtgccata gaaagtgcgc ccgcctcatg tgtatgcggg ttgccttctg 2028721 tttcacattt gattgtgtat cccggaccgc ctgtaccagt tccgtgcggg catccgcctt 2028781 ggctgacgaa gccagggatc actcggtgga atgtaagccc gtcataaaag ccttcgttcg 2028841 caagcttttc aaagtttgca acagttccag gtgcagcttc aggataaagt tcaaattcaa 2028901 ttttgttccc gtcttctaat aaaaagtaac ctgttttcaa ttgtatgcct actttcttta 2028961 ttttaatttt caaaggagat tatgtatagg ttatagcctg tctctccttg tcgcggctat 2029021 tataccacac ctttcggggg aaaacgaatc tcccgagctt tactaaaaaa taaaaatgaa 2029081 acctgaatct ctttatctcc gtctaaccta acggaactgt atttttcatg attcaggtcc 2029141 tcacaaagca gcactatcca gctgcttgtg aaattgaagg aggtcaaact gctttgaaga 2029201 aaatttggat tggaatgctg gcagcggccg ttttgctgct gatggttccg aaggtcagtc 2029261 tcgcggatgc cgcagttgga gatgtcattg taacactggg tgctgatttg tcagaatctg 2029321 acaaacaaaa agtgcttgat gaaatgaatg tccctgataa tgccacaacg gtaaccgtga 2029381 ccaataagga agaacatgaa tatttaggaa aatatatatc gaacgcgcaa atcggatcga 2029441 gagcgatttc ttcatcgtca atcaccattg ccaaaaaagg ctccggattg aatgttgaga 2029501 cccataatat cagcggcatc acagatgaaa tgtacctgaa tgcactgatg acagccggtg 2029561 ttaaagatgc gaaggtgtat gttacagcac cgtttgaagt atccgggact gccgctttaa 2029621 ctggattgat taaggcgtat gaagtttctt ctgacgaagc gatctcggag gatgttaagc 2029681 aggtcgccaa ccaagagctt gtcacgacat cagagcttgg agacaaaatc ggtaacgaaa 2029741 atgcggcagc cctgattgca aaaatcaaag aagagtttgc taaaaacggg gtgcctgata 2029801 ataaagctga catcgaaaaa caagtggatg acgcagcttc tgatttaaac gtcacactta 2029861 cagacagcca aaagaatcag cttgtctccc tattcaataa gatgaaaaac gctgacattg 2029921 actggggaca ggtcagtgac cagctagata aagcgaaaga taagattacg aaattcatag 2029981 aatcagatga aggcaaaaac ttcatccaga aagtcattga tttcttcgta tctatctgga 2030041 atgcgattgt atctatattc aaataagaaa agcgccgaaa aatcggcgct ttcttttatt 2030101 gctttacacc cgttttaaat ggcagatcaa gttttacaat atcttcgtat gtttctcgct 2030161 tcacgactaa atgagcctca ccgttttcga caaatacaac ggcgggtctc ggaatacggt 2030221 tataattgtt ggccatgctg tatccataag cgcctgtaca aaaaacggca agaagatcgc 2030281 cttcttttac ttccggcagg tcaatatccc aaatcagcat atctccgctt tcacagcact 2030341 ttccggcaat tgataccgtt ttgtcatgcg cttctccgat cctgttggct gccgcagctt 2030401 catatttagc ttggtaaagc gcaggacgaa tattgtcgtt catgcctccg tctacagcca 2030461 catattggcg gacacccggc acttcttttt gagagccaac cgtataaaga gttgtgcctg 2030521 cgtctcccac gagagaacgg cccggttcga tccaaatttc cggaatgtca aaaccgtaac 2030581 gggaagcatt ttctttcaca gcttcgataa ttttttcaac gtattcagtg gcatgaagcg 2030641 gttcatcatc ttccgtataa cgaatgccga aacctcctcc aagattcagc accttggata 2030701 caaatgaata tgaatctctc cattcgtcta gttttttgaa gattttttcc gctgctaaca 2030761 caaaaccggc cgtatcaaag atttgcgagc cgatatggca atggacaccc agcagctgaa 2030821 tgtgttccga ttgtaatact tgttcaatgg cccgttcagt ttgtccgtta tgaagatcga 2030881 aaccaaactt tgaatcttcc tggcccgttg taatgtagtc atgcgtatgc gcttctactc 2030941 cgggcgtgat ccgaagaaga acatcgatgg agtgacccgt ttctttacat aggtcttcaa 2031001 gaagcgcgat ttcatagaaa ttatccacca caatgcagcc gatgcggtgc tcaagcgcca 2031061 tccgcagttc ttccctgctc ttattgtttc catgaaagtg gatgcgttct gccggaaagc 2031121 ctgctgcaac agccgtatat agctctcctc cggatacgac atctaaagaa agtccctctt 2031181 cctcagcgag ctgaatcatt gcgactgatg agaatgcttt gctcgcatat gccacctgtg 2031241 ctttcagccc tgcagaaata aacgcctgct taaagctttt agcacgctca cgtattaaag 2031301 ccacatcata tacgtaaaga ggtgtaccat atttctccgc taaatagaga gcatccacac 2031361 ctccgatttc taaatgacca tgttgatttt gtctgcttgt gccgtgtaag aacaatgtca 2031421 ttccctcttt ctccgcttat ggatgaaagg acagttttat ggactgtccc ttcataatta 2031481 agacatacat tatcatactc ttcagtcagt ttcaatgcga ttatgaattg gtaggctgcc 2031541 ttaagcgatt tttggggtga acgatgctgg gtcttacttt tgcgccaggt ttcgctgtgc 2031601 ggacaagaac ctgccacagc gcctttccgt taaagggaat cagcggccat aagtacggtg 2031661 tctgaaggga tttgatgctt gccatggcaa taattagcac tgtaaatccg atgacgagcc 2031721 cttttatatg aaataaagca acgagtatca tgaggacaag acggctcatt ttgtttgcca 2031781 agcttaattc ataactaggc gtcgtaaagg ttccaatcgc cgcaagtgag acgtacagaa 2031841 tcacctcagg agaaaaaagg ccgacctcaa tcgcaatctg cccgatcaga acagcggcaa 2031901 ttaaacccat tgctgtcgat aaagccgtcg gtgtgtgaat ggcagccatt ctgagaaact 2031961 cgattcctaa gtcagctaaa aatatctgca ggatgatcgg gatatgcgta tctttattta 2032021 aaccgataaa tttcatgttg tccgggagca gatcaggctg aagcacaaag agaaaccaga 2032081 tcggaagaaa taaagtagaa gcaagaatac cgaaaaatct tacccgagct cgtggtcatt 2032141 cggcataatt acttaaattt tgtccagtct cccatcgtcc gctttaagaa tgtgataaac 2032201 ccggctttct tcatatcttc ttttgcagca acaggacttt cagcgagtac ttctccatcc 2032261 tttttcagaa caagagtgcc aagctcttgg cctttttgaa tcggagcact aatattgtcc 2032321 ttcatcttga tttctttttt cacatcgttc atatcctcgc cttttttcgt caatattgaa 2032381 atcggctcag atgtagtgag ttcgataaat ttttgtttcc cttttttgac ctttactttt 2032441 gctactgttt gatttcgttt atataaagga tgcgtttcat attggctaaa ggcgaagtca 2032501 agcatttttg tcacttgcgc gtttctttct ttaggcgtgc tcgctccgaa tacaaccgct 2032561 atggcccgca tgtttccttt tttagccgaa gcagtcagac aatatttcgc ttcgcctgta 2032621 tagcctgttt ttacgccgtc tacaccagga taaaatttga taaggcgatt tgtatttaca 2032681 agccaaaact ttttatctgt attttcacgc agataatctt catacgtgcc ggtaaacttc 2032741 gtaattgatt cgtatttcaa taattcctta gccatgattg ccatgtcata agcagagctg 2032801 tagtgtcctt cctcggtcag tcctgttggg tttttaaagg atgtattttt caatcccagc 2032861 tcttttgctt ttttattcat tttcttcaca aattcttctt cagagccgga aataaattca 2032921 gccatggcga cggaagcgtc atttcccgaa gcgattgcga tgcctttcag catttctttg 2032981 acagtcattt cttcgccggg ctcaaggaat atctgtgagc cgcccattga cgccgcatgc 2033041 tcgcttgtac ggaccttatc actcattttg attttgcctt tatctaaagc ttccataatc 2033101 aaaagcatcg tcataatttt cgtcatgctt gcaggcgcca gtctctcatt gctgttcttg 2033161 ttgtaaagca cttttcccgt gtcacgttct atcagcaccg cagacttcgc ttcatgagca 2033221 agctccgatg tacgttttcc gtcttgtttt gcaaatgcag acggtgcaaa tgtaagcagc 2033281 attataccaa tcaacaaagt ggataaaaga cgtttcatct caaaagccct ccatttcata 2033341 atccttttta ttttttccaa gcgtgatggt tttatacgcc actgatggaa aatgtttcga 2033401 attttgggca taaaaaaaga cagctgtgtg atatcagaca cagctgtctt ttggtcctgc 2033461 attgattcat atttattcgt actgagcgac gatcgcttta acaagcttta agaatccagc 2033521 ttttactttt tcggtcactt ccataacttc atcgtgactt aaaggctgat ccagaattcc 2033581 ggctgccgcg ttagagatgc aggaaatgcc aagaacccgc attcccgcat gattcgctac 2033641 aatgacttcc ggaacagtag acatgccgac tgcatcagag cccatcgttc ttaagaaacg 2033701 gacttctgcc ggtgtttcgt aagaaggtcc tgtcacagca gtgtacacgc ctttttgaat 2033761 tgggatatta aggtctttcg caatcttttc agccaggctg gacagatctt tgtcataggc 2033821 tgaagacata tctggaaatc tggcgccgaa atctgcttcg tttggcccga ttaacgggtt 2033881 tgttcccata aagttgatat gatcggtaat aatcattaaa tctcccgcac ggaattcagt 2033941 gttgacaccg cctgcggcat ttgtcacgat caacgcttcc acaccgagcg ctttcatcac 2034001 gcgtacaggg aatgtgactt tctccattga gtagccttca taaaaatgaa agcggccctg 2034061 cattgcaatg acggaaactc cttcaagagt gccaagcaca agctgtccgg catgcccttc 2034121 aacagtagat accgggaatt caggtatatc ttcatatttc agcttgaccg gattttcgat 2034181 ttcgtccgcc aaaatgccaa gacctgagcc taaaataagg ccgatctttg gagattccgg 2034241 caggttttgt ttaataaaag cggctgcgcg ttcaattctg tccttcaaga aacagtcccc 2034301 ctattgtaat aaagataaaa agcttttccc gtatttcggt ttatttgttt ggaaattatc 2034361 agcgatcgtt gcgccaatat cggcaaatgt atctgcaagc ggcagcattt gcgctttctt 2034421 atgttttttg ctgtaagcga gaatcggcac atactcgcgt gtatggtcag tcccatgatg 2034481 aatcggatca ttgccgtggt cggctgtaat aattaacaga tcgtcttctc tcattttttc 2034541 aaacacttcc ggaagccgcg catcaaattc ttcaagcgcg cgtccgtagc cttcagggtc 2034601 acggcggtgt ccgaataacg cgtcaaaatc aacaaggttc gcaaagctca gacccgtaaa 2034661 atcttctccc agcgtatcga tcaccttgtc cattccgtcc atattagaaa ccgttctgcg 2034721 tgaagaagta atgccttctc cgtcgtaaat atcagagatt ttaccgattg aaatcacatc 2034781 taagccgcag tctttcaatt cattcatgac agtgcggtca aacggcttca gcgcataatc 2034841 atggcggttt ggcgtccgtt tgaattgacc cggctctccg acgaacggcc gtgcaataat 2034901 gcggccaacc atatatttcg gatcaagcgt cagctctctc gccgtttcgc aaatgcgata 2034961 cagctcctca agcggcacaa cctcttcgtg agcggcaatt tgcagaacag agtcagcaga 2035021 cgtgtaaaca attaaagccc ctgtctccat gtgctcctgg ccaagctcat ccaaaatcgc 2035081 tgtgccggaa gccggcttgt ttccaataat tttgcggcca gatctctttt ccagctcttg 2035141 aagcaattca tcaggaaagc cttccgggaa cactttaaac ggtttatcaa tgtataaacc 2035201 cataatctcc caatggccgg tcatcgtatc tttgccgttt gacgcttctt gcatttttcc 2035261 ataataggca agcggatgtt ctgttttttc tacacctttg atatcttcga taagaccaag 2035321 gccgagcttt gccatattcg gcatatgtaa tccgttcata tgctcggcaa tatgaccgag 2035381 cgtatgagcg ccttcgtcat taaagtcagc ggcatccggc gcttcgccga ttccgactga 2035441 gtccatcaca attaaaaaca cacgattata tttgtatgca ggcatcttga aagcctcctt 2035501 tttttctata cgtctattgt atcgctaaga ggtctgacaa ctcaagtata aaccgttttc 2035561 attcccgttg acaatgtatt tggaaataat gagaaacttc aatattttct gtcgctctaa 2035621 acaaaaaagc cgcagccacc tgcggctatg ctcgcggatg aaactgcttg tacacatcct 2035681 tcagccttgt tttcgtcaca tgcgtataaa tttgcgtcgt ggatatatcc gcatgaccga 2035741 gcatttcctg caccgctctt aaatctgccc cgttctcaag cagatgcgtc gcaaaggaat 2035801 gcctgagtgt atgcggagtc agctctttct taatgccggc ttccaatgcg atttttttca 2035861 ggttcttcca aaatccctgg cggctgatct gtttgccgtg atgatttaaa aagagggcgt 2035921 cagatacatt attttttaac agttttcccc tggcttttgt catatattcc tcaatggcgg 2035981 aagcagcggc ttcaccgatt ggcacaatcc gttcttttct tcctttgccg aagcatcgga 2036041 taaaccccat agataaatga acatcagccg ttttcaattc aatcatttca ctgactcgta 2036101 tgcctgtcgc ataaagcagc tccagcattg ctttatcccg atatccgaaa gggctcgtca 2036161 gcttaggcgt gtccaataac cgctcgactt cattgagcgc gagcaccttc ggaagcgccc 2036221 gttccgtctt ttgtgtttcg atatgaacgg aagggtcctt atccgttact ttttccctga 2036281 gcagaaattg atgaaaagag cgaatggatg ccaaatgccg cgccgatgtc ttgccggatt 2036341 tccccgagtc cttcaaatgc tttaagtatt ggataatatg tatgcgggta acgtgattcc 2036401 aatctgtaac atgaagggtt tctgttaagt agagagaata gcttttcaag tcacgttcat 2036461 aggatacgat cgtattttga gagagccctc tctctaccat aacgtagtgg atgaaatcct 2036521 ttatttgatc tttcactctt gatctactcc ccgttttggt aaaaaaagat caaccggtcg 2036581 aaccatccgc ctttttcatc ctgatccatt tcaacaactt ttacagcgga gccttccggt 2036641 ttatcatacc gatgatagtt ttcatactct tgattcaccc atatcatagc ataatagaac 2036701 aaagcggtaa aaccggtaaa caggatgaaa actttcaatg catcgacagc tgttttcagg 2036761 aatcttccca tgtcctaatc gatcctttcc ctatggttcc agttatataa accatatgcc 2036821 aaatcagaaa ggttttatac atagaaacag caaaaaaccc tttccccatg agaaaaggtt 2036881 cgcgctcggc accgtctatt cagtttcttt tccgttacag cggtggcaaa tgccgtgaaa 2036941 cgtcaatcta tgatctttaa tcttaaattt ccaatcacgt tcaatgattt cttccacgtc 2037001 ttcaagcaaa tcttcttcaa tttcatcaac ggctccgcac tccatgcaca ccaagtggtg 2037061 atgaaagtga gctgcgccct ctttccgaag gtcgtaacgg gacacaccgt ctccaaagtt 2037121 aattttatct acgactttta attcagttaa taattcaagc gtacggtata ctgtagcgag 2037181 accgatctca ggagatttct cttttacgag gaggtataca tcttctgcgc ttaaatggtc 2037241 ttcttcgttt tcaagcagca ctcttactgt cgcttcacgc tgtggcgtaa gtttatagct 2037301 ggatgagtgc agttgtttct taatacgatc aatacggttt tccatgtctt tccctcctac 2037361 gccgcattcc atgactcatt ataacaaaat acgcgcagag ttccaactat aattattata 2037421 aactgataaa taaaatggtt ttcttttaat aatgatttta aaaaagtcta gatgtaagct 2037481 tttccattaa aacaggagat aagtatgctt caaagagaga tgaaatcagc gctaaaaaca 2037541 gaatgaccag cagcacaaag gcataccgcc cgaaccattg aatcggcgcg tcatgcaggc 2037601 ttcgtttcac gaacagctgt ctgattaact ttaaagaaaa cgcaattgca catgtgccca 2037661 taatgagata agccggaatc agcagcacat tttgcggcaa aacggagaca aatgatagga 2037721 aaaacccgct tactcccatc tgattgacta ggaacccgac agtaaagccg acgacgatcc 2037781 ctttcagaaa gatcataatg aaaataatcg gcatcccaat gacggaaatt cccagtatcc 2037841 acatcaggcc taaatacttt gcattatgaa agatactttg cccaaacata tcagctgaac 2037901 ttgcctgttt tccatccgaa agctgtccaa aaaattgact taagtagtag tataaatctt 2037961 ctttctggct gatggtcata ctgttgacaa taatcgcgcc aaagatgaca cccatgaaaa 2038021 acagcactga cacaaatata taaagagaga gatgatcttt gacatgcctg agaaacatgt 2038081 ccttataaga gatttttcgc ataccgtttc ctcccgcccg ctctagtgat ttgatttaat 2038141 agattgtatg aaagaaacag aaaaacatgc cctttttcaa aaagaaacaa tagagatgaa 2038201 tgctaggcgg ctttttgggg cacaaaaaaa tccttatcat caactgctgt atgatcataa 2038261 ggattcttat gcttccgttt attcaaaatc tcttttttgc tttttgtcat tcttccatgt 2038321 gtgctgaaag atggtgtgct gcctcttgat aataagacgt cacgtccgcc gtttctcaat 2038381 cgatgccccc gcttcttttt cgcttggctt tttgccatgt gatcactccc ttttttattt 2038441 tcatagtaat gataacaaaa ttgaacaatg ataagaaaaa aacagcacct gctacgacag 2038501 gtgctgttta gctacattta tttcactgct gtaagagctg catgctcgac agctgctgct 2038561 accgcatgat ggacttttga atcaagcggc tgagggacaa catcaccttg tttagtgcaa 2038621 gctgcgatgg cctctgctgc tgcgacaagc atatcatgat taatctccgt gctttttgcg 2038681 ttaagcgctc ctctaaaaat ccctggaaaa ccgagtacat tattaacaga acgcccgtca 2038741 gctgcatatg cggcgccagc ctgcagtgcg gcctccggct caatttccgg cttcggattc 2038801 gataaagcca gaatcacttg accagaacgt acaaatgccg gttttattaa acccggaacg 2038861 cccgttgtag caatgacaat atcacatgtt tccataagct cctcaatact ggaaactgcc 2038921 tgtccgccgt attgttcgag acggttcatt gctgactctg atttgtctgt tccgtataca 2038981 gcattcacac cataagccat gaacatccgg cagatggcca cgcctgctgc gccaaggccg 2039041 atttgcccca ctttcgcttc cttcaggtca acccccgcac tcctgcatgc cgaaatggca 2039101 gctgccagcg tcactacagc tgtaccatgc tggtcatcgt gcataacagg gatgttcagc 2039161 tcctctttta ggcgatcctc gatttcaaaa caatgcggcg aaccgatatc ctcaagaagg 2039221 atgccgctaa agcccggaga aatatgtttt actgttttga tgatttcttc aggatcactc 2039281 gtatcaagca gtatcggaat gccgctaata cccgccagct gatcaaataa agcagccttt 2039341 ccttccatga caggcatgcc agccacagag ccgatattcc caaggcctaa aattgcggtt 2039401 ccatccgtta caattgcaac agaattgctg atcgttgtat aaatagaagc tttttcaggt 2039461 tctttttcga tcagtcggca cacgtccgca acacctggtg tgtagacacg tcccagctct 2039521 gccagtgaac ggatcggcat tttgcttttc atttggattt ttccgccttc atgtgcggac 2039581 aggacttcat cagatacggt gtgaagcctg atcccttctc cgagggcctg tacagccgcg 2039641 atcacttcct gaagctgttc ttcattctcc acttgaacgg taatattccg cattgtgtaa 2039701 ttgggtccga cttttaccgt ctccacttca ccaatatccc cgcccagaag gccgatggcc 2039761 gtagccaccc ttccaagatt tccgggaacc gaaggcgttt cgatcatcag tgtccgaatc 2039821 atgtgtttcg ctatcattca gtgatcctcc cctattagcc tagtttttcg gctttaactg 2039881 tattgttttt cgtataccat ataaattttc ctgtataacc atagataatt gcaagaccta 2039941 ttgctacaaa actgagccac ataaacggca gataagagaa ggtagaaaca cctaaaatac 2040001 cagccatgta aatcccatta tcagaccaag gaaccatccc cgaagtcaat gttcccccga 2040061 cctctgagtt acgtgataac actcttctgt ccagatgtaa gcgatcatag ctgtcttcca 2040121 taattttcgg agtcaaaata agagatacat acatcgcaca gccgaagatg tttgctaaaa 2040181 acgctacgat cagtgtagac aatgtgacat tgccggctga agttaatttc ttttcaaacg 2040241 ttgaaacaat gacttttaac acgccgagtt tctcaagcag accgccaaaa ccaaggccaa 2040301 agatgatgac gacgagagaa tcaagcatac cgacaattcc accgcggttt aacaagccgt 2040361 tcaaaaattc aacatccgtt ttaatagaga agccgttgta cgcagttgca atcgcatggg 2040421 caatatccat tccttggaaa acaacagccc agattgcacc gagtaaagcg ccaattacga 2040481 taactggcat agatggcttt ttcatcgcca ataagactat gacgagaact gccgggatca 2040541 gcatccaaat atgaatgtca aacgtgtttt gcaaagatga ttttaagaat tcaactttat 2040601 caagatcaat atttttcccg ccgtacataa atccaacaac tgtaaagagt atagctgtaa 2040661 tgacataagc aggtattgat aaataaagca ttgctctcac gtgagccaat acatcgactt 2040721 ttgatagtga agaagctaga actgtactgt cagacagcgg agacagcttg tccccaaaat 2040781 aagcacctga aagaatagct cccgctacta gaggaagcgg aatgcctaac ccctctccaa 2040841 ttgcgatcat ggcaatgccg gcagttccga ctgttcccca tgacgttcct gttgccacag 2040901 acataatgga acaaataatt aacgttgcca gtaaaaagat acttgggtga ataaattcca 2040961 gtccgtaata aatcaaagtc ggcacaacgc ctccggcaat ccatgttccg atgagcgccc 2041021 caactgaaac gagaatcagt acggcttcaa ggccatttga tatcccatgt acaatcgcat 2041081 tttgtaaatc tttataagaa taaccgagtc taatacctaa aagcattgca ataaaccatg 2041141 aaacaaaaag cgccagctgt atcggcaagt cgagaaagac tgtaaacgat agaacaagtg 2041201 ctaaaaatac tcctagtaca ataataattt caaatagtgt tggcaatctt acatccttca 2041261 aaagaagtcc cccttcatgt aaaagctaaa acgctttcaa tatatagtgc aacacgtata 2041321 ctatacttcc tcatccctat gttgtaaaca gcttattcat ccgactattc ggagatgaat 2041381 aagctgtatt ttatacaaat tttatttttc taatagttct ttccctgcga tacctggttt 2041441 ggtcatctca tatgggttta aaataatatc caattcttct tcagtcagca catcatgctg 2041501 cagacaaaga tcccggacag attgccctgt cataattgct tccctggcaa ttctagctgc 2041561 cgcttcatac ccaagatgcg gattgacagc tgtgatcacg cctgcgcttt tttctacgta 2041621 ttgcttcata cgcttttcgt tggcttcaat gccttttaag cagttgtcag tgaacgaacg 2041681 gaagccgttg ttcatgatgc tgatggattg aagcaaatta aagacaagca cgggctccat 2041741 gacgttcaac tcaagctggc cggcttctga agcaaggcag attgtattgt catttccgat 2041801 aacctggaac gcaatttggt tgatcagctc cgccataacc ggattgactt tccccggcat 2041861 aatagatgaa cccggctgac gtgcaggcag agaaatttcc gcaagtccgg cgcgcggtcc 2041921 cgacgccatt aagcgcaggt cgtttgcgat cttcgacatg ttcatcatgc agacttttaa 2041981 tgaagctgat acctctgtat aggcatctgt attttgtgtc gcatcaacaa gatgatcagc 2042041 gccgacaaga ggaagcccgc taatatcagc aaggtgcttt actacctgtt tgatatattc 2042101 aggatcagcg ttcagccctg taccaacagc agttgcgccc atgttgactt catacaggtg 2042161 ctggcgcgat tgcttgattc gtttgatatc acgctcgaga acacggctgt aagcttcgaa 2042221 ttcctggcca agacggatcg gaaccgcatc ttgaaggtgt gtccggccca ttttaataac 2042281 agagtcaaac tcctgtgctt tttgcttaaa cacactatgc atatcttcca ttgttttcag 2042341 cagtttttct aagagcttca atgtggaaat atggatagca gtcgggaaca catcgttcgt 2042401 agactgtgac atgttcacat gtgtgtttgg acttaaatgg atataatctc cctttttatg 2042461 tcccatgatt tcaagcgccc ggtttccgat aacctcattc gcgttcatgt tcatagaagt 2042521 tccggcaccg ccctgaatcg gatcgacgat aaactgatcg tgccacttgc cttccagaat 2042581 ctcgtcagcg gcttgtacga tagcttggcc aattccttca tacagccgtt tcacgtccat 2042641 gttggcaaga gccgcagctt ttttcacaat cgccagtgcg ttaatcattt cctcatggat 2042701 tttgtatcct gtgatcggaa aattttcaga agcacggagc gtctgaattc cgtaataaac 2042761 atctgcttca atttgttttt ccccaaggaa gtctttttcc acgcgatatt ctttttggcc 2042821 gtttaacata atctttaacc ttctttctct ttgctggtta tcgtttttac attttacagg 2042881 acaacgtcat cagctatcgg cgtttccata attctcttga cgacaggaag atccgaagac 2042941 tgacctagcg cccacatcaa ttttggcaca attgcttctg tgttcatatt tcttgatcgg 2043001 ataattaagt cttggttgac tctgcggcca acctcgtaaa tgctcatgtc ttcgccttct 2043061 tcaagacatt gagtcgtaat gacgacgaca atgccgcttt cgatcagttc attcactttt 2043121 gacaaaatgt ctctgccttc aaacggcact cctccgctgc cataactctc aatgacaatt 2043181 cctttgtaca tgcttttcag ggcatcaaac atttcgggct ttaagcctgg atgcagcttc 2043241 agcagacata catctgtgca tagtgaagtg tcaactgtga aggtgtcgtt ctcaggttcc 2043301 gttacttgtt tgttgtattc gatcccgtct tcattgataa aagcgatata tgggtaattg 2043361 atgctttcaa atgcgtcgta gcttttcgtt cttaatttga tcgcacgcgt tccctgaatg 2043421 actctgccgt caaacacaac ataaacgccg cccacgcctt cacaggcaaa tcgaatggca 2043481 tctgtaatat tttttttggc atcggttttt tggaacgtga tcggaatctg cgagccggtg 2043541 atgacaatcg gctttttggc atgctgcagc atatacgata gtgcggcaga tgtataggcc 2043601 attgtatctg taccgtgagt aataacaaac ccgtcatagg catcataatt ttccttaacg 2043661 gcttctgcta tttccaccca gtattcaggc tgcatattgg tgctgtctat attcataagc 2043721 gactgagttt ccattgtgta atcgttatca agttttgata cgtaacttaa taattcatca 2043781 gccttgactc cgggagccag cccattttcc ccttcaactg aagcaatcgt tcccccagtt 2043841 gtcaacatca ataatttttt cataccatgc acctcttcac tgtatctaaa gatgggttgc 2043901 gagaaggtat tcgcttttcg catactttta atgcaattat agacacggaa aataaaatac 2043961 gcaagacatt attattcaat tcgcgtacac ttcctaatac ctatatgata taatcagctc 2044021 aaggtgaaaa aggagcggaa gttcatgaat ctagatcgtt taactgaatt gagaaaaaag 2044081 aaaaattggt cgcttcaata tacagctgac cttctcggta tcgcaaaaag cacatatgcc 2044141 ggctacgagt caggctaccg acggccttca cttgaagcgc ttgccatgct ggctgacctc 2044201 tttgacacaa cctgcgatga acttttaggc cgcgagaaac aaaagcagac tgctcctcag 2044261 gccatagaat tggccacgtg gagcagcctc gactttacca tttctgttga tggccagccg 2044321 ctgagtgaag atgaaatcat ccagctgatt acctttatac gcacaaaaag aaaagtacag 2044381 gaggaactga gttaatcttt agctcacggt ttaattttac cgtaggttcc tcctcctccg 2044441 gctttcaatt ccagttttcc ggatctcgct tttacgataa gcgccgcggt tttcggcggg 2044501 acaacgcgag ccaaatcttc ttctgcagcc tcatgaagaa cagccatttc tgttccgaag 2044561 gcttttttta gtttgtccag cgttttcggg cctacacccg gaacaaattg cagcgggatc 2044621 tgatgtacat atcgcggacg cgggacgcga acttcaagct gatcactcaa ttcacgcaat 2044681 ctatcgctga ctcccttggt aaatctggct tttccgcaat tcgcgcacgc tgtttccccg 2044741 cttacagcag gctctccgca cgcttcgcaa gccgtctgat aatatttccc caataacggg 2044801 tccaagccat aatttgcgat aattttcctg tcatcttgtc cctttaatgc aagagcaaat 2044861 tcagtaaaat cagctgactg cacatataat tcattatatt ctctgccgat tttccccaac 2044921 gaatgcgcat cagaatttgt taaaaaagga tacggattca attgcgatac gtgtgatgcc 2044981 atgtctgtat cacagcttaa tccaagctcc accgcgtcta tcatagatgg atcaaaaacc 2045041 tcagttaagc ttgatttaac cccttttcca tataagcttt tatgcggcgt aaagatatgg 2045101 gcggggataa acaggccgcc catatcctgc actttttttt gcaggtttaa gcccgtttca 2045161 taaatccgct gcgagcttaa atgaatattt ttcagccggg ctgacagcca gtttgaaaac 2045221 tgtttcatat cagccagcgt cggcataaat acgagcacat ggatcggtcc gctgcaggct 2045281 tcatcataaa tctccagctc gctccccaat aaaagagtcg tgctgcgata acggattcct 2045341 cccccgtcaa gctcgcgata ttttccagat gaaatgcctt cctcaagctc tagaatgact 2045401 tccggagaat gacagtcgat aatgccgagg agttcaattc ctttatgttc actggcttca 2045461 accaaaattc tgtccagcgt taatgttttg gcgcctgtta ttttgacagc ccttcctgta 2045521 aaggtccggc cgatatgaat gtgcaaatcc gcgtaaatct ttttcatttt tgtgcttgga 2045581 gcgcttcttt cagctgaaga tactgaatcg cgtaggctgt tttagcatca tatacttcac 2045641 gcgattcaac cagctttagc gcatcttcaa gcgtcacctc catcacttca acaaactcgt 2045701 cctcatcaag ctcccgtttt tcttcaagca cagaaagctc ctcagcaaga aaaacgtgaa 2045761 cgatttcatc tgcaaatccg ggtgatgtat aaaacgcagt tatttttgtc agtttttttg 2045821 ctgtataacc ggtttcctct tcaagttccc gaagtgccgt atactccggc tcctcacctt 2045881 tttcaagctt accggccgga atttcaacga tcgtccgctc aagcggctta cggaattgtt 2045941 tgaccatgat gattttccct tcatctgtga cggctagtac cgctacagct ccagggtgtt 2046001 tcacaatttc acgtttactg gctttgccgt ttggcagctc tacatcctcg acataaagat 2046061 caatgacttt acccgaaaaa atctgttctt tggcaattgt tttttcttct aatgatttca 2046121 tttcttcatc tcccgttctg tctctatatg atgccccata cattttatca tactagagca 2046181 aaagggggct tcttcgtgaa agtgcaccgc atgccaaaag gtgttgtctt agtcggaaaa 2046241 gcatgggaaa ttcgagcgaa gttaaaagag tatggacgca catttcaata tgtgaaagat 2046301 tggatctcaa agccataaaa gttgaaactt tagctccttt atattacggt caatacaaag 2046361 cctaaaaaag gagtgtgcac atgagaaagc gcaaattggg tacatctgat ttagacatta 2046421 gcgaagtcgg actcggctgt atgtctcttg gaactgaaaa aaacaaagca ttgtccattc 2046481 tggatgaagc gatcgagctt ggcatcaact atttggacac agcggatttg tatgaccggg 2046541 gacgcaatga agaaattgtc ggtgatgcga tccaaaacag acgccatgat attattctgg 2046601 caacaaaagc gggaaaccgt tgggatgacg gaagcgaggg ctggtattgg gacccttcaa 2046661 aagcttacat aaaagaggcg gtaaaaaaga gccttacacg tctgaaaaca gattatatcg 2046721 acctttatca gctccacggc ggcacgatag aggacaacat tgatgaaacg attgaagcgt 2046781 ttgaggaatt aaaacaagaa ggtgtcatcc gctactacgg catttcttcc atccgcccga 2046841 atgtgattaa agaatatgta aaaaaatcaa acatcgtcag cattatgatg caattcagcc 2046901 tgtttgacag acgccctgag gaatggctcc cgcttttaga ggaacatcaa atcagcgtag 2046961 tcgccagagg tcctgttgcc aaagggctct taactgaaaa accgcttgat caagcttcag 2047021 aaagtatgaa acaaaacggg tacttgtcct attcattcga ggaactgaca aatgcccgta 2047081 aggcaatgga ggaagtggct cccgatcttt ccatgacaga aaagtcgctg cagtatctgc 2047141 tagcacagcc ggctgtcgct tcagtgatta caggcgccag taagattgag cagttacggg 2047201 aaaatattca ggcagcaaat gcacggcgtt taaccgaaga ggaaatcaaa gcgctccaat 2047261 ctcatacgaa acaagacatt tacaaagctc atcgctcata gcagaaaaac cagcacctgt 2047321 acgggtgctg gtttatttat attgatgcca atccatttgg ctttcattta ggagttcttc 2047381 aaagctctta tttttttcga tctctttttt ctttctaatc tgttctgctt tttctctttt 2047441 ctgcctcttt tcatcctctt ccttcaattg gctcttcatc tccataagct ttgctttgat 2047501 atcggattga aggccgtctt ttagctggtg tttgtcaatg gatttttgtt ttttcatgca 2047561 gacttccccc atgttttgtt ttgaagccag tttatcacgg agcatataaa ctgaacaagc 2047621 agactctctt ctgatcactt tctcagcgta gcagtgttta ggtataatga tcttaaacac 2047681 gaattgccta tatatttcgt tgaaaggtgc tgtgactttt gaagaaaatc cttttggcca 2047741 ttggcgcgct cgtaacagct gtcatcgcaa tcggaattgt tttttcacat atgattctat 2047801 tcatcaagaa aaaaacggat gaagacatta tcaaaagaga gacagacaac ggacatgatg 2047861 tgtttgaatc atttgaacaa atggagaaaa ccgcttttgt gataccctcc gcttacgggt 2047921 acgacataaa aggataccat gtcgcaccgc atgacacacc aaataccatc atcatctgcc 2047981 acggggtgac gatgaatgta ctgaattctc ttaagtatat gcatttattt ctagatctcg 2048041 gctggaatgt gctcatttat gaccatcgcc ggcatggcca aagcggcgga aagacgacca 2048101 gctacgggtt ttacgaaaag gatgatctca ataaggttgt cagcttgctc aaaaacaaaa 2048161 caaatcatcg cggattgatc ggaattcatg gtgagtcgat gggggccgtg accgccctgc 2048221 tttatgctgg tgcacactgc agcgatggcg ctgattttta tattgccgat tgtccgttcg 2048281 catgttttga tgaacagctt gcctatcggc tgagagcgga atacaggctc ccgtcttggc 2048341 ccctgcttcc tatcgccgac ttctttttga agctgagggg aggctatcgc gcacgtgaag 2048401 tatctccgct tgctgtcatt gataaaattg aaaagccggt cctctttatt cacagtaagg 2048461 atgatgacta cattcctgtt tcttcaaccg agcggcttta tgaaaagaaa cgcggtccga 2048521 aagcgctgta cattgccgag aacggtgaac acgccatgtc atataccaaa aatcggcata 2048581 cgtaccgaaa aacagtgcag gagtttttag acaacatgaa tgattcaaca gaataaaaaa 2048641 gcgaaaggcc tcttcggctc tttcgctttt ttatgttaca gaacgtcggt aatgccatcc 2048701 atattttctc tgatccattc aatcgcaaga tctatcgttg taaactcctg cgtctcgaag 2048761 gtcatttcat cctgcaatag ccagacatct ttcttgatgg actctgctcc tccgattgac 2048821 cagtgaagca aggtataagg atggttttga ttcaggaagg atacccacgt tttattttgt 2048881 gctgtgttct tcattgcctt cagcttttgt tccacgtttc gcgtctccta ctttactaat 2048941 atgctcattc tggggctgag catttcagcc gggcttttca gcgccaatgt tttggctttt 2049001 tcattgtaat cgatcgtcat ttgatcgtca aaaaacactt tttgcgacga ttggatatac 2049061 agcggaatgc cgttcgtttc cagctgctcg cactgtcccg ttaattcttc tgccagccag 2049121 attgtcggga caccgcttac cgcgcagccg catccttctg catcgtaacg aagctgggct 2049181 ttttttcccg ggttggcgtc aaacgcctgc tgcagtgcct gttttgctgc atctgtcaca 2049241 tgtatgttca taaggtgaaa cccccgtttt catcattttc gctattgtag catacaatac 2049301 tgccattcgc attgtttctg ccttttttcc accgcttcgc attttcttct gcagtcttga 2049361 tccactcatc tttcccttgt atatactgat tgatgctgtc agggtgctgg gccgccagct 2049421 gttttttgag aacggcgtat tctttcgcta tgtttggatg agctctgaga taatctctga 2049481 ataacagatg cctttcaata gcagggtttc cctgttcgta catatggaca tgatgagtgc 2049541 gtttatttcc gcccttttgg aaataacgcc tgcccgctat accgttctca ccttttggtg 2049601 tatagccgtt ggccttcatt tgttcatcaa attggctcac ggcttcaatg cttctgactt 2049661 caattaacat atcaatgatt ggcttcgctg ccatgttagg tattgatgtg cttccgatgt 2049721 gatgaatagc gataatctcc ggcccgaaca caagtttcag ccgttctttt tcttcatcga 2049781 aacattctgc ccatttttcg ttgtagagaa tgatctcaac ttttcttttc ggatacaaat 2049841 gaaagaccga cagcaataga ccctgcgctg ctttgacggt ttctgccttt tggaatccgg 2049901 cctgtgtata gagtgacaca gccggggtat tgttctcggc tgtgactact tcgattttct 2049961 cagcgtcttc attatgatca atgacaaatt gcagaagcgc tcgtccaatt ccttttctga 2050021 aaccgtcagg atgcacaaca agcctgcaaa tggtgagata atgcatgttt ttctcatatg 2050081 aaatgacacc gatcagcttg ccgtttttcc gatatcccgc aaaccgttca tgggatgctt 2050141 gaatatcctt taccttctct tgtaaagcgg gaataccgtc aaaaccgata atctctgttt 2050201 cctttatgta ggcggggatc tgtacggcta aaatctcacg cgctatagtg gcttccttat 2050261 gctggagaaa ttcaatcatt cgtgttctcc tgaaacagcc gctgtctgtc gacttttgcg 2050321 acgcggactg catacgactc gtaccaaacg cttcttcctt tttcttttgc tgcttgatgt 2050381 tcagtgtgat gcctccaatg gttaattgcg tccatactgt cccaatagga aactgtgatg 2050441 ccccttccat ccgcttcacg tacgctttcc acgcctaaaa atccaggctg atccgccgca 2050501 agtgatacca tccgctccgc tgtttctcca tatcctgtgt cattttcgct tttgacagaa 2050561 gaaaaaatga ctgcatagta aggaggctca ggtgtttttg ataaaaaatc catcatattt 2050621 ccccctcata tgtttttgac aaatagtacc ctgtcttggc ccgggccatc atagtttgca 2050681 aacactgaga tgccatttac cgttttggtg cccttttcaa tatcaaaccc caattttgtg 2050741 tgatatgcga ttgatacctt attcacaggt gaagtgacac acttcacccg ggtgcagccc 2050801 ctttgtttta ctgtttcgat aaatacatca tacaattgtt tcccaatttg catttttctg 2050861 aaatccggat gcacaccgga aaaatgaatg tacgccgttt caggatcgga ttgcgattga 2050921 aatccgatta aaaatcccgt catgctgtta tgttcggatg taataaagct tgtgtcctga 2050981 aaatgctcaa aaaatagtct cggcaatttt tctttcagct gtctgccgcc ccaccattca 2051041 ttcagtacag acgttaccat ttcataatct gaagacgtga ttgttcgaat atccattacg 2051101 atttgatctc cctccgtctg gcaaaacgaa tgtcagctct ttttctcaca atataaaaat 2051161 tatattttgc ctggctggaa ttgtaaatgc cttctttcct gtatcatacg tttccagact 2051221 gccgagggaa caatgtttga tcattttacg cctatttctc ccccaaacag gaggagagac 2051281 tttacagcac aatatcaagc acttgatcaa gtttcagctt ataaagctga tcctcgtctc 2051341 cttttatcca tactgctttt tcaaactctt cataccggca gattttcccg gtgcagcaga 2051401 caatctcacc gtcctgaaag cagctgacag tgatatcctg agcaaactcc atcgcggcgc 2051461 aaagcgtttg attcatctct tccagcttat cggggtcaag gatcggcttt tgcagcttct 2051521 gtttaagtcg ctttctctcc agcaggcttt gcttatgttc cggcagaaac atcctgctcc 2051581 cttcccacag caggttgccc ctttttaaat ggtcgttcat ttataatgcc cccctatttt 2051641 agccgcacgt tcaaatgcct ggcctgccgc tgtcagtgac gccgccctga tgattgctgt 2051701 atcgccgaat cgatttttaa tgccatccat cacatagcct aggctcattt tctttgcata 2051761 atcctgaaat aaattgagct gccatatgtc atcagatgag agctgagaca gattgacacc 2051821 gaggcggcgg acgggtttcc cgtcccaaaa tgtaagaaac agccgtcgta cagcctcata 2051881 tacatcctgc gtagaattag tcggctctgc cagcttcact tgccggttga agcccgtcgg 2051941 ccaatcaaaa tcagcacccc ggcagctcac tgacactgtc tgccccatga ccccggcgtt 2052001 tcggcttcgc ctgcacacct cttcactcag ctcaagcaat acgaccttga tttctttgtc 2052061 aaagtgttcg tagtctctcg ggagagtcat tccatgacct atcgcctttt gcccgtccag 2052121 agacgaagtt gacacagggg aatagtcgat tccgtttgcc gtcatccaca gcacgtggcc 2052181 gttaatgccc catttctttt ttaaaagatc gagcggaaaa gccgcgagcc cgccgatcgt 2052241 gctgatgccc attcgattta aatgatgctt catgcggctc ccgacgccaa acatgctgcc 2052301 caccgggagc ggccacattt cggttttcat attttctttc gttaaggtaa aaataccgtt 2052361 cttattcttt ttggcaaaat tgtcacacgc aattttggcc agcgctttgt tagggccgat 2052421 tccgacccgt gcataaacgc cgatctcccg catgattctg ccctgaatgc ttttcgcgat 2052481 ctccatcggc gtcccaaaca gcttctggct gcctgtaatg tccatgaact gttcatcgat 2052541 ggaatacggc tccacaaggt ctgtatactc ctcgagaatg gccgtaattt gcagtgatac 2052601 atcaatatac cgctgcatac gcggccggag cacaacagcc tcaggacact tttcctgcgc 2052661 ctcccacagc cgtgaagcat tcaccacacc cttttgtttc gccagcgggc aggcagccaa 2052721 tacgactccg cccctttttt cagggtcacc cgaaacaatg acgggcctat ttttcaaatg 2052781 tggattttcc gctttctcta cagatgcata aaacgattgc atgtcaacga gaaaaatcac 2052841 tttttctttc atcatacaca cctctaaaaa gaacttatgt tcgcttttca ttatatgcga 2052901 aagtatgttc gttttatact ggtaaatgat tcttgtctga cagaaaatat gatccaaggg 2052961 tttgagagaa gaaaaacatt tagtagaata aaagcgaagc ataaggatag gagagtcatg 2053021 atggagaaat ttgtcgaaaa aatgctggga caggcattgc ggcaatacgg cagaaacgtt 2053081 gctatagatc cgttaagccc gtatgaaaaa caaagcctga aagcggctct acaagagaga 2053141 cggaatgaag aaccagatga ggatttgcat gcgcatatag aagatatcat ttatgactat 2053201 gtcacaaacc aaggcctgtt ctcttaaacg catgactgtc agttctttca gccgctgatg 2053261 cggcttccct ttgaaaacac cgcctgaaac aaataaacag tctcaggctt acagaaaaaa 2053321 agcaggattt tctcacgctc catagattca tatggcctgg cgtaaaattc ccctcaatgc 2053381 tcgcgcaaaa cggaataagc tgtccatgat cacgcgtata cactttttcg aagagatgtg 2053441 ctctcttgtt ctgtcatgcg gtccatgccg gttttcagcg tacatcttga tctcatagcc 2053501 ggtttcactg ccgatatgat ccacgttctg gcggcttaaa ctaacacacc ctcactgacc 2053561 aatcgctttg cttttcatcg gacatcccgt cattttcctt ctttcaagat gtaaactccg 2053621 tcagccacac gcatcctcaa cgcatagtat attgccatcc atacaatcag gcatactaca 2053681 tgtcaataac gaaatatttt gaacgatcta ttggagaagg aaattttttc atatatgata 2053741 gagaaagatc atacatacag gagagaatat aattcatgaa gaaatggaaa gatatccacc 2053801 cgatcagctg gacaattata atcggaacca ttttcggcag aatggcaaca tcgatgagca 2053861 ttcctttttt agcgatttat ttgacagccg tccaaggcgc atcagcttcc tatgcagggc 2053921 tggtcatcgc cgcgagctca tcagtcggca tcctcgcaag cttttacggc ggatatatct 2053981 cagataaatt cggcagaaaa aacatgatgc ttgtatcgat tttcggatgg atgctggtat 2054041 ttgcaggctt tgcggcagca tctaatctct gggtgttttt tgtagtaaac gcattaaacg 2054101 gtctttgcaa atcactgttt gagcccgctt caaaggcctt gttgtctgat atgacagaag 2054161 aaaaaacgag actgctagtt tttaatttac gctatgcggc tattaatatc ggcgttgtct 2054221 tcggacctgt gcttggccta tatttcggct catcgcaatc gactacgccc tttttggtgc 2054281 ctgcagtcat ttacggacta tacggaattg tgcttgccct ccaatttaaa aaacatccat 2054341 ccttatcagc accagcccag tcccgaaata tgagcgtgcg ggaagcgttt atggtcacgc 2054401 aaaaggatta tctttttacc attgctttgg tcggcattac gctatgcacc ttcggctact 2054461 cacaattcag ttccacattc cctcagtata tggcgcagaa ccccttgatc ggcaatggaa 2054521 cgaagctgta tgggctgatg ctgacattaa acgcaatcgt tgtgttggcg acgcaatttc 2054581 ccattgtcca ttttgcaaaa cggttttcgc cgctttgttc tctgatgctc ggtaatgtga 2054641 tggttagcat cagcatggcc attttcaccg tatcacacgg tgttccatca attgtgatga 2054701 ttgtcatcac atttacaatc ggcgaagtgc ttttattctc tatgatggat ttgtatgtag 2054761 accagattgc aaaaccagga ttaaaaggca cttatttcgg ggcaatcggt ttttcacagc 2054821 tcggaaacgt catcggccct tgggtcgggg ggatatgtat agacctgttt ggcgctggcc 2054881 ggccgattta tattttttct gtcctgagcg gcattaccct gctcggcctg ccatttttag 2054941 cgttcgccta tcggcaaatg aaaatggaga ccacaaaaca ccgttcccgt ctggaaaagc 2055001 cgctttaaat aaaaaacgga agagaatgaa tctctcccgc aaacatgagg tgaagaacat 2055061 gaatataggt gatgtgatgt ttcagctgtt tgtatttatt atatttgccg ctgtcgtctt 2055121 tgcggctgtt acaggcttca agtatgcgaa aaaccgaaaa gcgcagctgg atcgcattga 2055181 gaaaaagctg aacagcctgt ccgaagatca cgattaacag cttggggcaa cgagctctac 2055241 cttaatccgg tctggatcct cacaaaagac tgcataatgc ccgtctcctc cggcaaaagg 2055301 atgcctgtct cggtacaaca cacgatagcc ttttgccgtc aatttttcag tcatctgatc 2055361 gacttgaagc ttggattcag catgaaatgc gagatggttc agaccgactc ggcatctatg 2055421 gtattccggc tctagaaatg gctctttcgc ctgcacaatc actaggtaaa aacgatcttt 2055481 cttccagctg atgcctgagc tccatttttg atactcttta taaccaagtt cttttaagaa 2055541 ccagccccaa aaccgcctag acgcctccaa atcagagaca tacagttcaa tatgatgcac 2055601 atttcatacc ctccttacca acacttcctc gaccttatgc ccgtctccct tacgcaaaat 2055661 gagatctgac ctgaatttag ttggcaaaat attttcatat aaattcggcc ggttgacact 2055721 ctcccaaatc gaggctgcca tctcgtcagc ctcctgatcg gacaagtctt taaatttatg 2055781 aaaatatgaa tcaggatttt gaaaagctgt ttcccgaagc aggcgaaaac gctctaaata 2055841 ccaagtgaaa atccggcttt cctccgcatc cacataaatc gaaaaatcaa agaaatcgga 2055901 aacaaaaata cgcgggtttt cccggtcatc ctccaaggtg ggcgactgaa gaacattaat 2055961 gccttcaata atcacaatat ccgcctgttc tacaacctcg aacacacctt cctcgcggtc 2056021 ataggttaga tgggaataca ccggggcctt tacgctgtcc tttcctgatt ttaagtcatt 2056081 caaaaattcg agcagcgcct ttacatcata gctttcagga aatccttttc ttgacatcat 2056141 atttttcttt ttcagctcgg cagtaggaaa taaaaaacca tctgtcgtga taaggctcac 2056201 ttttggacgg tcaggcaaac gcgaaagcag cttctgcaag atccgcgccg tcgtgctttt 2056261 tccgactgcg acactgccgg caatgccgat aataaacgga attttggctg aatgtgggtg 2056321 cttcaaaaaa acattgacat gcttattgcg ttcagccgca gacttgacat gtaaatgaag 2056381 caagcgaaca agcggaatat agatcgtctc cacttcttca acagatagat aatcattcaa 2056441 tccttccaca gcttttgcct cttcttcaga tacagcaatc gacaaatgcc ccccaaaacc 2056501 agaccaagac tcccgattgt gctgtgtata taaagtatgt aggttaagtt ctttattttt 2056561 cactgtttac acctgactct ctgtaggtta aaacccttac aaagattgta acggaaaacc 2056621 ttttcactgt ctgcttattt ttcatttcgt ttttttagca aatcagcacc gattcggtta 2056681 tacgcagcca tttcatcttt tggaaccatg cttcctcccg ttccccagac gacatgtacg 2056741 gcatgttcca tcttatattt ctgagcatag cgccttccct cttctgtcga aaaaagctga 2056801 accggcccga acatgccagc aagagcagag ggctctaaat atttatcttc agatacagcc 2056861 agcatatgaa gcaaagtata aagcgtattg tcctctaccg tataacagcc gctcagaagc 2056921 ggttcaatca gcttgccgac aaatcctgac ggcctcccta cggcaagtcc gtcagcagcc 2056981 gtctgattat ccaggccgat atcctggacg gagatcttct cgtgaagtcc tgaataaagc 2057041 cctaacagca tacaaggtga atgagttggt tctgcgaaaa acacatgaac atcatctccg 2057101 tataaaagct tcagcccaaa tgctacaccg cccggtcctc cgccgactcc gcacggcaga 2057161 tacacaaaca agggcgtctc aagacttggc tttatattca tacagtcaag ctgtgttttt 2057221 aatcggcttg cagcaacagc atatcctaag aacagctgac gagaatgttc atcatcaata 2057281 aaataacaga atggatcttg ttccgcctgc cgtctccctt cgttcaccgc ttcactgtaa 2057341 tctgtttcgt actccataac agtgactccc ttttggcgga ggagatcctt tttccactgc 2057401 ttagcatcgg cggacatatg cactgtcacg cgaaacccga gtgccgcgcc gatgatgccg 2057461 atgcttaaac ctagatttcc tgtcgaaccg acagcaatcg aatagcggga gaaaaacccg 2057521 gtaaaccgct cttcctgtaa gatgcggtaa tcatcggttt cctgaagcat tccttcttga 2057581 agcgcgagat tttcagcata ctttaacact tcataaatcc cgcccctcgc tttaatcgat 2057641 cctgaaatcg gaagctcatg gtcgcacttt aaaagccatc ttccgggaaa tggctgctga 2057701 tatgccgctt ccagctttcc cttcatatgc tgcacctcaa aaagcggaga ctcgatgatt 2057761 cctttagcgc ctttcgtctc aggaaacacc tcggcaatgt aaggtgcaaa ccgctgcatt 2057821 cttttttccg cttccgctat ctcggttgcc cactcatctg cacggggtaa tggcccctct 2057881 ttcttgcctg aatttgccca gaatacaggc tctgcatcaa tcagtttctg aataaacgga 2057941 tctttaagca gagcatgaag gacttctgaa tgaactgaca ttcaacaatc tctcccttcc 2058001 actatcaaaa actgccccgt gagaaacaag ccactccacc acaggcagtt ctatcattat 2058061 tttttcatga gcgcgcgtcc tgccagcttt tctacaagag ctggaaacag ctgatacagc 2058121 ttagtgccgg cattcattaa acgcggaaga ttgatctccc gctttttcgt aaaaattgca 2058181 gctgtaattt gagctgccac gtcatcagga tcaagcatcc agcggccgac atttttggcg 2058241 tagtccccgc ctttatcagc aatggaaaaa aagtccgtct gaatcgggcc cgggttgact 2058301 gttgtcacat aaatgccggt tcccgaaagc tccatccgca aagcgtttga gtaacctaac 2058361 acggcatgtt tggtcgcgga atacaggcta gacttcggtg tggcgatttt ccccgcttga 2058421 gaggcgatat tgatgatatg tccctttttt tgctcaagca tttgcggaag caccgctttt 2058481 gtacaggcga tcaggccgaa gacattcaca tcaaacatcg ctttcatgtc atccaatgta 2058541 gagtctaaaa ccgtttcaaa tataccgaag cctgcattgt taatcagtac atcaatcgag 2058601 ccgatctgat cgcggacccg ggcgatatcc tctaggcggc cgacatccag aggaaaaatc 2058661 tcacactgtc cgctccattc ctcggttatt ttccttttga tttctatcaa acgatcctcg 2058721 cgtctagccg acagcaggac atgggctcct tcagccgcgc ataagtatgc gattctttct 2058781 ccaagccctc ctgaagcgcc ggttatccaa atcctttttc ccgctatatg tttcacccat 2058841 ttcacctctt cattgtttta aagtatacgg tatttccttc ccaatatgac gtgatggctt 2058901 cttcagcctc caacacatca aggtgacctg ccgtttctga catcgttaaa aacaattcct 2058961 tttcatatac agcaggaaaa agctgctgac agacctgaaa agcggtcatc ggcttttcat 2059021 ccagcatgcg acgcacatcc tccgtcctgt tcctctgctt gtcaaaacgc ttctcaatca 2059081 gcgcttgtac actggtgata ggctcgccgt gaccaggaaa tacgattgtt ggatcaagtt 2059141 gagacagcct tcgcaatgac cgctgataat ccactaaagg ctttgacctg acgtctcccg 2059201 ctttcggcgc ttccaaaatc ggattagacg agctgtttgc cagcagtaga tcgccgccaa 2059261 gcatccttcc gcttttttca tggaacagaa caatatgcga ttcagcatgt ccaggcatct 2059321 ccaacacaga ccagccctca agcccatcta tgcccatacc ttctctgatt gattttgtca 2059381 gagatctcgt acaggaaaat gcgtacgctg atcgaatcag cttttccgcc ttccccgtat 2059441 caaatggaac gcctaattca ggcagcagct tttgaaaaaa acgtttttgc caatccataa 2059501 aggcttgatt ttggctgata taaggttcgt tgaatgtatg cccaatcact tcgatttcat 2059561 ctgaaaagac atcaagcaag cctgcatgat cagcatgatg gtgagtcagt acaacctgct 2059621 cgatatctga caatttcaca tttacagcgg caagctgctc ttgtaaggct ctggcagcct 2059681 cttttgtatt cggcccggca tcgataagtg tcagcgcatc accttttacg aggtaaacga 2059741 taacatcgcc gacagcaaac ggtgtcggga cgcggatcgc aattacatct tcagttgtca 2059801 tcctttcgct ccttgtcttc attcattatt catattttag ctttttctcg gtcttgtgtc 2059861 attattgcag aatgagaaca aacctttttg aaaaagctat tgacattagc ttgtccgcca 2059921 ttgcataatg aacaacaaac taaaacgaga accattggaa cgctatgacg aggaatagta 2059981 tacaaggcaa tggcctaaga gagcgatacc cccggctgaa aggtgttgcg gcccgcttgt 2060041 ttgtagaacc tgccctcaag tcgcggttag gaaaacctaa acgtttcccg cgttacgggg 2060101 atttgagctg agcacaattt gtgctaatga gggtggtacc gcgaaccttt tcgtccttta 2060161 cgtgatgaaa aggttttttg ttgttctaat agaaggagga tatcaatgaa aaagatagga 2060221 tttgtcggcg ccgggtcaat ggcagaagca atgatcaacg gcattttgca aagcggcatc 2060281 acaaaaccag aacatatcta tattacaaat cgctcaaatg acgagcgtct gattgaatta 2060341 aaggaaacgt acagcgtgcg tccatgcaga gataaaaatg agtttttcac tcacaccgat 2060401 atcattatcc tcgctttcaa accgaaagac gcggcggaaa gcatcgacag catccggccg 2060461 tatatcaagg accagcttgt catttcagta cttgcaggcc ttaccatcga aaccattcag 2060521 cattattttg gcagaaagct cgcggtcatt cgcgtcatgc ctaatacatc agcggcaatc 2060581 agaaaatcag caaccggatt ttccgtaagc acggaagcaa gcaagaatga tattattgcc 2060641 gcaaaagctc tattggaaac aatcggtgat gcaacactgg ttgaggagcg gcatcttgac 2060701 gctgtcactg caatcgcagg cagcggcccg gcctatgtgt atcgttatat tgaggcgatg 2060761 gaaaaagcag cacaaaaagt aggattagat aaagaaacgg caaaagcact cattttgcag 2060821 acaatggcag gggcaacaga tatgctcctc caaagcggca aacagccgga aaagctgcgt 2060881 aaagaaatca ccagtcctgg gggcactaca gaggcaggtc ttcgcgcttt acaggactcc 2060941 cgctttgaag aagcaattat tcactgtatt gaagaaacag ctaaacggag cgcagaaatc 2061001 aaagaacagt ttgccggtgc cgccttagag agacattctt agatgtaagg acaaaaacag 2061061 aaggcacagt gccttctgtt ttttattttt cccgcagcag ctggccggca gattctgatt 2061121 gctttaatag cgcggagatc gtaaatgaaa gcaaatcggg aagcacttca aaggaataag 2061181 gcatatacaa tctttccgtc catttatgcg ggtctttacc agccggaccg acatttaaaa 2061241 ctgggacata taaagcctga tttttaccgc ttggcaatga ataccctctg ttaaagagcg 2061301 gcatattgct tgtgtatgca tcaacctcct gtttttccag ctgaagataa ctcaagtccg 2061361 aaagtccggg gaagtactga acctcccgta atgcaatgcc gtatcgctca gccgcataat 2061421 gctttatctg atctgctgta tttctgatca attgatcatc ctttgaagaa acagctggat 2061481 aaagcggcgg actataaaac agaacgatga gcggcgcatc ctccttacaa agcgaagcaa 2061541 gctcagaaac aattttcgtc gaaaaatccc tgtctccaag ctcccccctg ttagcaaagg 2061601 cataatttag agcccgctct gtttccgaga tccccgcacg cttttttgca cgcgagacca 2061661 gctcatcaaa tgtcaaaaca gtgacgtccc gctcaatcgg ctgaaatggc tcaaattgtt 2061721 gaaaatcctg tgttttcttc cgaacgttcg acatgatttc ctccgccgcc tgttctgctg 2061781 ttttaagcag catctgatgc agctcactag ctgagcgttt cattgacagc acattaaata 2061841 atgtgacggc tgtatgcggt gtctggactg aatatgcctc tttcaagtcc ttttgcatta 2061901 agtttaccgg cggcggagtg acctcgccat caaccttttc gcaataatca gcattcagtt 2061961 caagcaaacg gttaatctca gataccatta aatttgcgtt tagacctgaa aacggctctc 2062021 caacatgtgt ctcaatcccc ttgcagaaaa aacccgcaag caccttgcca atgcttcctg 2062081 tataaaaata ttgctgctga tcgccgggaa atttttcaaa catcggttcg gcattcaggc 2062141 aagcggttaa tgtgatatca tgctttttct ccatctcctt caatgcagga accgcttcaa 2062201 tcatgcctct tgaattcact tcctcgtccg gaaccgttat caacagcaga ttgccctcaa 2062261 aatgcccgtt cattgccctc tccagcatcg acagttgaat acaaagcccc gctttcatat 2062321 ccatcgtccc tcttccgaac agccagtctc cgctttcggc atctcttctc acacgttccg 2062381 ggagcagctc ttttttctct aaaaaggagc tcaaaagctc agcaggcttg caagccatat 2062441 gtttaaattc gccgtaatct tctatgtcaa cgacatcaaa atgactcagc agaagcactg 2062501 tctttttgac attcttcttt ttgactagag ccgtaagaaa agatctgcca tcgtccatcg 2062561 gatgaagtgt tacatcatca gggtgctttt gaaaataggg cttgtccttc aaaataaaat 2062621 aaagatactc tgcaagcgct acctcgccct ttgaaccggt gatgctttcg tattgcacaa 2062681 gagaagttaa aagtgccagc aattcgtcct tcgtctgcca attcattgat tccgcccctc 2062741 ctatgaataa aaatgcttct atactgaaaa ataaactgat ttctcgtcta ttatacagaa 2062801 atgtttgaca aaagcggttc atttgagcag tttatatgac gggaaagaaa tgacttgata 2062861 taatcaatct ctaaaaacct tacgggaggc gaaagaaatg gccagaaaat tatttacacc 2062921 tattacaatt aaagatatga cgttaaaaaa ccgcattgtc atgtcgccaa tgtgcatgta 2062981 ttcttctcat gaaaaggacg gaaaattaac accgttccac atggcacatt acatatcgcg 2063041 cgcaatcggc caggtcggac tgattattgt agaggcgtca gcggttaacc ctcaaggacg 2063101 aatcactgac caagacttag gcatttggag cgacgagcat attgaaggct ttgcaaaact 2063161 gactgagcag gtcaaagaac aaggttcaaa aatcggcatt cagcttgccc atgccggacg 2063221 taaagctgag cttgaaggag atatcttcgc tccatcggcg attgcgtttg acgaacaatc 2063281 agcaacacct gtagaaatgt cagcagaaaa agtaaaagaa acggtccagg agttcaagca 2063341 agcggctgcc cgcgcaaaag aagccggctt tgatgtgatt gaaattcatg cggcgcacgg 2063401 atatttaatt catgaatttt tgtctccgct ttccaaccat cgaacagatg aatatggcgg 2063461 ctcacctgaa aaccgctatc gtttcttgag agagatcatt gatgaagtca aacaagtatg 2063521 ggacggtcct ttatttgtcc gtgtatctgc ttctgactac actgataaag gcttagacat 2063581 tgccgatcac atcggttttg caaaatggat gaaggagcag ggtgttgact taattgactg 2063641 cagctcaggc gcccttgttc acgcagacat taacgtattc cctggctatc aggtcagctt 2063701 cgctgagaaa atccgtgaac aggcggacat ggctactggt gccgtcggca tgattacaga 2063761 cggttcaatg gctgaagaaa ttctgcaaaa cggacgtgcc gacctcatct ttatcggcag 2063821 agagcttttg cgggatccat tttttgcaag aactgctgcg aaacagctca atacagagat 2063881 tccggcccct gttcaatacg aaagaggctg gtaatgccca taagagatat cctgtagagg 2063941 atatctcttt ttttattttt agagaaacga tcggctaagg ttctccgtct ccctagtaga 2064001 accaattaga ggagatgact ccaatgaaat cagcttggat ggaaaagaca tatacaattg 2064061 acggatgtgc gtttcataca cagcaccgga aaggatcaag cggtgtaacg attgtctttg 2064121 aggccggcta tggtacttct tctgagacgt ggaaaccatt aatggcggac attgatgatg 2064181 aatttggcat tttcacatat gatcgggcag gcataggaaa aagcgggcaa agcagagcta 2064241 aacgaacagc tgatcaacaa gtgaaagaat tggagagttt gcttaaagca gctgatgtaa 2064301 aacctcctta tttggctgtt tcacactcat acggagctgt catcaccggt ttatgggcct 2064361 gcaaaaacaa gcatgatatt atcggcatgg tccttcttga cccagcttta ggcgattgcg 2064421 ccagctttac ctttataccc gaagaaatgc acaaatcaca tacgagaaag atgatgcttg 2064481 agggcacaca tgcagagttt tcaaaaagtc tgcaggagct caaaaagcgg caagtccact 2064541 taggaaacat gcctcttctt gtgttgtcat caggagaacg gactgagaaa ttcgctgctg 2064601 aacaggagtg gcaaaacttg cacagcagca tattgtctct atctaaccaa agcggctgga 2064661 ttcaagctaa aaacagctcc cacaacatcc atcatgatga acctcatatc gttcacttgg 2064721 ctatttatga cgtatggtgc gcagcgtgcc agcaggccgc tcctctttac caggcagtca 2064781 attaacgtaa aaaaagaccg ggccgtaagg gattcccggt cttttatatt attttgtttc 2064841 acggtgaagg gtatatttct ttaaacgcgg tgaatatttt ttcagctcca aacggtctgg 2064901 attggtgcgt ttattttttg ttgtgatgta atttcggtct cccgtttcag tgcaaagcta 2064961 aagtaacatt tactctcata attaacatct ccttataaaa cgtaatgatt acgttttatt 2065021 atacaacgtc atcacaaatt gtcaaataag agctccgcct tcagcctcgc gggacgttta 2065081 cctctaagaa atcatatgcc gccacgctat tggggaaaac gtcaaccgct tctttttgaa 2065141 gctccaaaga agcatctccc tgatatcttg cgctgatatg ggttaaaatg agctgcttcg 2065201 ctcttgcttc tttcgctgtt acagccgctt gttccgttgt actgtgataa taatcataag 2065261 caagtttacg gtcttcctta gcaaaggttg cttcatgaac aagcacatca caatccctcg 2065321 caagctcttt tagtttgtca cttactctcg tatcaccgga gaacacaaca gatcttccct 2065381 ttttaggagg ctccagaaaa tcattcccat tgatgattcg tccgtcttca agcgttaccg 2065441 tttcgccttt tttgattttc tgatatacag gtccgggcgg gatgttcatt tcttttaata 2065501 cgtcagcctt caaggaaccc ggtacgtctt tttcctgcac acggtacccg aaggcttcca 2065561 ctccatgaat aacagatacc gctgtgacaa taaactgatc gtcctcaaac acgattcctt 2065621 cttcaatttc ctggatcgca agcggatatg tcaaatgggt tttcgtgacg gcaaggcttg 2065681 tttcaataaa cgccttgatc cctttaggtc cgtacactgt cagctcgtcc tctccgcctt 2065741 gaaaggaacg gctccccaga agccccggaa gtccgtatac atgatcgccg tgcatgtgtg 2065801 taataaagat tttctctatt ttacgaggtt taatcgttgt atgtaaaatt tgatgctgtg 2065861 tggcttcccc gcagtcaaaa agccataccg aacgcctttc ttcaagcaat tttaatgcca 2065921 ccgacgttac atttctcgcc ttggcgggga tgccggctcc cgtccctaaa aaaagtaatt 2065981 ccacgtttcc ttcctcctac tagaaccaga tacctacaag aatacaggat caagcggaaa 2066041 atgtgaatct tgcctctgaa aagaacaatc ctttcgtgct agaaacattt tttcagcatt 2066101 ctgcttaaaa aagggcttaa atgtttgctt tcgttgaatt ttagatttaa aatgaaggaa 2066161 atatacgggg tgtactaaaa taaagcttcg aataaagtga ggtactttta gtgaaaacaa 2066221 accaacaacc aaaagcagta attgtcatat tcggtgcaac tggagattta gcaaaacgaa 2066281 aattgtatcc gtctattcac cgtttatatc aaaacggaca aatcggagaa gagtttgcag 2066341 tggtaggagt tggaagaaga ccttggtcta atgaggatct tcgccaaact gttaaaacat 2066401 ccatttcctc atctgcagat aagcatatag atgatttcac gtctcatttt tactatcacc 2066461 cgtttgacgt gacaaaccct ggttcttatc aagagctaaa cgtattgctt aaccagctgg 2066521 aagatacata tcaaattcct aacaacagaa tgttctactt ggcaatggct cctgaattct 2066581 tcggaacgat tgcaaaaaca ttaaaatcag agggtgtaac agctacaacc ggctggtccc 2066641 gccttgtcat cgaaaaaccg ttcggccatg atctgccaag cgcacaggca ttgaataaag 2066701 aaatccgcga agcatttacg gaagatcaaa tttacagaat cgaccattat ctaggcaaac 2066761 aaatggttca gaacattgaa gtgattcgat ttgccaatgc gattttcgaa ccgctttgga 2066821 caaaccgcta catttcaaac attcaaatca catctagcga atcactaggc gttgaagacc 2066881 gcgcaagata ttacgaaaaa tcaggcgccc ttcgcgacat ggtgcaaaac catattatgc 2066941 agatggttgc ccttcttgca atggagccgc ctatcaaatt gaacacagaa gaaatccgca 2067001 gcgagaaagt gaaggtgctg agagcactgc gtcctattgc aaaagacgaa gtggatgaat 2067061 actttgtgcg cggacaatat catgctggtg aaattgacgg tgtaccggtt cctgcttata 2067121 cagatgaaga taatgtcgct cctgactcca atacagaaac ctttgttgcc ggcaagctct 2067181 tgatcgacaa cttcagatgg gctggtgttc cattctacat cagaaccgga aaacgaatga 2067241 aagaaaagtc cacaaaaatt gtcgttcaat ttaaggacat tccgatgaac ctgtactacg 2067301 gtaatgaaaa caacatgaat ccgaacttgc ttgtcattca tattcagcct gacgaaggca 2067361 ttacgcttta cttaaatgct aaaaagcttg gcggagcagc acacgcacag ccaatcaaac 2067421 tcgattattg cagcaattgc aatgacgagt tgaacacccc tgaagcatat gaaaaactaa 2067481 ttcacgactg tcttcttggc gatgcaacaa actttgcaca ctgggatgaa gttgcccttt 2067541 cttggagctt tgtcgactct atttctgaaa catgggcagc aaacaaaacc ttatctccta 2067601 actacgaatc aggctcaatg ggaccgaaag aatctgatga tcttttggtg aaagacggct 2067661 tacactggtg gaacatataa taagaagaaa aaagccgaaa atgtttacaa gcattttcgg 2067721 cttttttacg ctgaacaaag gtataacaat ctccttaata acaaaacccc caaagcttaa 2067781 gagcttcggg ggtttctatt gattacttca tccattcagt atggaagatg ccttctttgt 2067841 cagtacgctc ataagtatga gcgccaaagt agtcgcgctg tgcttggatt aagtttgcag 2067901 gcagtacggc tgtgcggtag ctgtcatagt aggctaatgc gcttgagaat gatggcaccg 2067961 gcacaccttg ggcaactgca agtgaaatca cttggcgaag cgctccttga tagctttcta 2068021 caatattctt gaaatagctg tcaagaagca ggttgtcaag ctcaggctcg cgatcgtaag 2068081 cttctttgat cttctgaagg aatgccgcgc gaatgatgca accaccgcgg aagatcatag 2068141 cgatttcacc atatttcaga tcccagttgt attcttcaga agcagctttc atttgggcaa 2068201 atccttgcgc gtatgaacag attttactca tgaacaacgc ttttctgacc gcttcaatca 2068261 gctcttcttt attttctgta acaggcttca cttctggtcc tgaaagaagt ccgctcgctt 2068321 ttacacgctc ttccttcata gctgagataa agcgtgcgaa tacagattca gtaataatcg 2068381 gaagcggaac gcctaagtca agtgcgcttt ggcttgtcca ttttcctgtt cctttttggc 2068441 ctgctttatc aagaatcaca tcaacaagcg gtttgcctgt ttcttcgtct ttttttgtga 2068501 agatgtcagc cgtaatctca atcaggtagc tatcaagctc acctttattc cattcagcga 2068561 aaacttcatg aagctcatca gcagaaaggc ccagcacctg tttcagaatg aaatatgatt 2068621 cagagatcag ctgcatatct ccgtattcaa ttccgttgtg caccattttt acgtaatggc 2068681 cggcgccgtc cggaccgata tatgtcgtac aaggttctcc gtcaactttt gcagaaatgg 2068741 cttcaagaat cggttttaca agctcatgtg cttctttttg tccgccaggc atgatagaag 2068801 gtcctttaag cgctccttct tctccgccgg aaacgcctgt tccgataaaa tgaatgccgc 2068861 tttcagcgag ttctttgtta cggcgctgtg tatctttata gtatgtatta ccgccgtcaa 2068921 ttaaaatatc atccttctct agatgaggaa gaagagattg aattgtcgca tctgttgcag 2068981 ttcccgcttt aaccattaat aagattttgc gcggtgtttc caaggattgg acaaattctt 2069041 caatgctgta agtgccaaca acattttttc cttttgcctc ctgtaaaaac tcctcagttt 2069101 tactgcttga tctgttgtaa acagaaacag aaaatccccg gctttcgata tttaaagcca 2069161 gatttttacc catgaccgca agtccgataa cgccgatttg ttgttttgac atattctaac 2069221 gtcccttctg caaacgttta atcattttaa aatttaaatt aaaataaaat gatatttata 2069281 ataaagaaat taccatacat tcaccctttt tttcaagcga ttcagctttt cttttcatct 2069341 tgaaaaaaat ctttattaaa gcttgttccc tttgttttgc tctcctcttt ttttaacgtt 2069401 gccccttttc tgatcagttt ggtaccgtac tttttattca gcttttccat catctgctga 2069461 atgggctcat ccttcgcatc ttcattaaag ctgaacaaat cgagctgttt ataggcctgc 2069521 tctttttcta ctaaatccgt tccggtaatg ccaagcagcc tgacaggatt tttattccaa 2069581 tgtttaaaaa agaggtgctc cgcttctttc aaaatgtcat ttttttgatc aatcgggttt 2069641 ctcagcgtag tgcttcttgt gatggttctc caatccgcat atctaatcat aataaaaagc 2069701 ttcgaagcca tgacttcctt gcgctgtaaa cggtcactca cagaagcggc aagctttcta 2069761 aaaacgccta acagctcttc ttcatcactg gaatcatggg aaagtgtcga tgagttgccg 2069821 acgcttttaa attcgtaaat gcgctccggg tcaaccggcg catggtgaat gccatttgct 2069881 ttatttttaa ggcgcggacc gttgatgcca agcaggcgct tcagcgagtg ttcatcagct 2069941 gcagctagct ctccgattgt atggatgccg agtcccttca gtttttccgc tgtctttttg 2070001 ccgactccgt gcatctctcc aacaggaagc ggccacagga tatcgggcac ttgcctcttt 2070061 cttaagatcg taattccaag cggttttttc atatcagacg ccatcttagc gagaaattta 2070121 ttcggtgcaa tccctatgct tgacgggagc agcagctctt tttgcagcct gctttggatt 2070181 tcttttgccg tctctagagc gcggctgctg tatggtgtat cggtcatgtc catatagcct 2070241 tcgtcgatgg agacaggctc cactaggtca gtatattcac gaagaatggt aaacatcgct 2070301 cgtgaagagt ttctatagcg gtcaaagttc ggcggaagaa cgatgagctc aggacaatgg 2070361 cgcttcgctt gccaaaccgg catcgttgtt ttgacgccgc gcgctcttgc ttcgtagctg 2070421 catgttacca caatgccctt tcgctccttt acgtttccgg caactgcgac cggctttccc 2070481 cggagagccg gatcatatgc catttcaacc gacgcataaa agctattcat atcaatatgg 2070541 aaaataattc ggctctttcc cggcataaac aaatctcctt ttcggtcatt agacaacagc 2070601 ttgtacatat agtaaaatga agctattgaa tggatgtgat gacaatgttt gtggaatcga 2070661 taaatgacgt tttattctta gtcgattttt tcacaattat tcttcctgct ctaacggcaa 2070721 tcgggattgc attcctctta cgggagtgcc gtgcgggcga gcaatggaaa tcaaaacgaa 2070781 cagatgaaca tcagacggtc tttcacatta accgaacaga ctttcttatt attatatatc 2070841 atcgcattac aacttggata cgtaaagtct tccgcatgaa ttcgcctgtg aacgatgagg 2070901 aagacgccgg ttctcttctt ttataaaccg catttataaa aaggaggaga acaaaattgt 2070961 taaaaacata tcaaaaactt ttggctatgg gtatcttttt gatcgtatta tgctcgggca 2071021 atgctgcatt tgcagcgact aatcaggtgg gaggcctcag caacgtaggt tttttccacg 2071081 attatttaat cgaaccgttt tccgctctgc ttaagggtgt tgccgggctg tttcacggag 2071141 aatacggact ctctattatc ctcgtaacca ttattgtgcg tatagttgta ttgcctttgt 2071201 ttgtcaatca gttcaaaaaa cagcgcatct tccaagagaa aatggccgtt attaaacctc 2071261 aggttgacag tatccaggtt aagttgaaaa agacgaagga cccggaaaag caaaaagagc 2071321 tgcaaatgga aatgatgaag ctgtatcagg agcataatat caacccgctt gcgatgggct 2071381 gtcttccaat gctgattcag tctccgatta tgattgggct ttattacgcg attcgctcaa 2071441 cacctgaaat tgcgtcacac tcgtttctat ggttcagttt agggcaatct gatattctca 2071501 tgtcccttag tgcagggatt atgtattttg tccaagccta tatcgctcaa aaactgagcg 2071561 cgaaatattc cgctgtcccg caaaaccctg cagcgcagca atccgcaaaa ttgatggtgt 2071621 tcatcttccc tgtgatgatg acgattttct cgcttaatgt gccggcagcc cttccgctgt 2071681 actggtttac aagcggactg tttttgacag tgcaaaacat cgtccttcag atgacgcatc 2071741 ataaaagtaa aaaaacagcc gctcttactg agtcggtgaa ataaaaaagc aaccccgtgc 2071801 aaaaagccgg ggttgttttt tgttacttgc aaagtaccgc gccaaacagt cttgtttatc 2071861 atggctgaag cagaaatggc catcctaaaa aatagccgta tcgtttaaaa agaaggaaat 2071921 cgggaatacc tttactcacc tccaaccgaa aggagcctat acgttgacgg aacgctttca 2071981 gcaaaaaaat atttctgtac ctgatggaat ctggatcatg agacaaacct ggaatgatgt 2072041 cttatttgct cactggcctg ttgatgtttc tatccttcgc gctttggtac cgtccgtttt 2072101 agaattagat acatataacg ggcaagcttg gatcagcatg cttcccttta tgctcacgaa 2072161 cctgagggcg cgttatctcc ctgtcattcc cggtgcgcgt gcatttcctg agcttaacct 2072221 ccgcacctat gtcacgtata aaggcaagcc cggcatttat ttttttagct tagatgccga 2072281 tcatcgtctg gcggtccttg gcgctcgcac attctttcat ctgccttatt tttacgcgga 2072341 tatgaagtcc gaaaaaaacg gtgatgccat tgactatgtc agcaagcgga aaaatgacaa 2072401 agaagcagca ttccacgccg cataccggcc aatttcagcg ccttttacag cagaaaagga 2072461 ttcgctcgat tactggctga cagaacgata caggctctac accacttatc gcaataagct 2072521 ctattacgaa gacatccatc atcatccgtg gctgctgcaa aacgccgaag cagaaatttc 2072581 agtcaatacg gtgactgatg ctcacggtat tacattgccg gagtcagacc ccttgcttca 2072641 ttatgctaaa aaacaggatg tgttattttg gccgcttagg aaatggagct aaaaaaaccc 2072701 gatgcgggaa atcgcactcg ggttttcttt ttttattttg ccgcctcttc aataatggca 2072761 acaaccattt ctgccgtttt aacgagctct tcgatcggca ttttttcatt ttttgtatgg 2072821 atttgctcat aaccgacagc aagattgacc gtcgggatgc catgaccagc gattacgttc 2072881 gcgtcgcttc cgccgccgct cgtttgcagc tcgcttggac gtccgatttt agcagccgct 2072941 tttttcgcga tttcaacaac ttggtcgccg tcttgatatt taaagcccgg atacataacc 2073001 tcaatttcga cttctgcgcg tccgcccata tcagcagctg cctcttcaaa agcagctttc 2073061 attttttgaa cctgagcttc cattttctca ggaactaaag agcgcgcttc agcaagaata 2073121 tgaacttcgt cgcacacaat gtttgtttgt gtgccgcctt caaaccggcc gatattagct 2073181 gttgtttctt catcgatacg gcccaatggc atttttgaga tggctttgct agcgattgta 2073241 atcgctgaaa tgcctttttc aggttcaacc ccggcgtgag cggttttccc gaaaattgcc 2073301 gctcttacct tcgcctgtgt cggcgcggcc acaatgatat ttccgacttt tccgtctgaa 2073361 tcaagagcat agccgtagga tgcagtgatc atagaacggt caagcgcctt cgctccgatc 2073421 agacccgatt cttcccctac tgtgatgatg aattcaatcg tgccgtgttc aatattttct 2073481 tctttcagca ccttaatcgc ctcaaacatt gcagccaatc ccgctttatc atcagcacct 2073541 aaaatcgtcg tgccgtcagt tttgacgtaa ccgttctcta caactggttt tacgccgttt 2073601 ccgggtacaa ctgtgtccat atgagatgta aaatagatcg tatctgtttg ttttgtccct 2073661 tttagcgtgc aaatcaggtt accggctccg tggcccgtga tatccattgt atcgtcttct 2073721 ttaacgtcca cacctaaatc agaaaatttt cgtttcagca ctttgcagat ttcagcttcg 2073781 tgctttgttt ctgagtcaat ttggacaagc tctaaaaatt cttccagcag gcgtttttca 2073841 ttcaccattt gtaagtccct ccatattaaa gcggtatgtt accgtgcttt tttttcggtc 2073901 tctcttctgt cttatgtgta agcatatgaa aagcttgaat cagtcttccc cttgattctt 2073961 ccggcaaaat gatgtcatcg accattccac aagcggccgc tttgtatggg ccggcgtttt 2074021 gctttttgta ttcagcagtt ttttcgcgtt tcgtcttttg cgggtcagct gaagctttga 2074081 tttccttttc atacaaaatc gatgccgcac cttctggacc catcactgcg atttcagcat 2074141 tcggccatgc aaacacaagg tccgctccga tcgctttgct gttcatggcc acataggcgc 2074201 cgccgtacgc ttttctaatg atgagtgtga cttttgggac agtcgcttca gcataagcaa 2074261 acaataattt tgctccatgc ctgatgattc cgttgtgctc ttgctgaata cccggcagaa 2074321 accccgggac atcttcgaca gtcaacagcg ggatatcaaa tgcgtcacaa aaacggatga 2074381 accttgctgc tttatcagca gcgtcaatcg tcaggcttcc cgccagatgc ttcggctggc 2074441 tcgccacgat gccgattgct ttttcaccca gccttgcaaa cccaatgaca atgttcttcg 2074501 caaaaaatgg ctgaatctca aaaaaagact gcgggtcagc cagctcccta atcaccttcc 2074561 gaacatcata aggctttgtc gtatcagcag ggacaagacg gtttaataac ggtctggacg 2074621 cctctttctc tggcttcggc tctgttgtcc ggccattcag cggcaaataa gacagtagtt 2074681 ttctcacccc tgtcagaacc tccttctccg tatgcccgga aaagtgggcg tttccgctga 2074741 cggcattatg tatccccgct ccgcctaagc tctccgcatc aacctgttcc cctgtcactt 2074801 tttcaatcac cttcgggccg gtaataaaca tccggccagt ctgttcagcc ataaatataa 2074861 aatctgtgag tgccggagaa tatacagcgc ctccagcgca cggccctaaa ataaccgata 2074921 tttgcggaat gactccggaa tataagacgt ttcggtaaaa tatgtgaccg tatccatcta 2074981 atgataacac accctcttga attctcgcac cacctgagtc attcagcccg ataatcggcg 2075041 ccttattttt tgctgccaga tccatcaaag cgcagatttt cctggcatgg gtttcgccaa 2075101 gcgcccctcc gtacactgtg aagtcttgcg caaatacata aactgagcga ccgtcaattg 2075161 tgccgtaccc tgtcacgacc ccatccccta acatgcgctg ttctcttgtt aacacttgac 2075221 tttccatgaa ggggtgtaat tcgataaagc tgtcctgatc tagaagaaat atgatccttt 2075281 cccgagcagt gagcttgccc ttttgccgct gctgagccag cttttcccgt cctccgcctt 2075341 cttctgcctg cttgcgtttc gtgtaaaaat gatccatgtg ctcattcatg ctcattgtgt 2075401 tggtctcctt tcggttcaca aagctctaca agaacaccgt ttgtttcccg aggggaaata 2075461 aacgcgatct ttttcccgtt cgctccctgt cttggaaacc tgtcaatcaa ttgaacatgc 2075521 tgatcagaca atgcttgaag ctgttcagat aggcagttgc acaaaaacgc aatatgatgc 2075581 agtccctgcc ctttcttctc caaaaataaa tggacggggc tgtcagctgt caacggctct 2075641 atcagctcaa gtttgacgct accagcttga aaaaaagcaa cattcacctt ttgctcttca 2075701 accgtttctt gatgaagaaa tgcaagcccc aatacatttt cataaaagct tcttgcatct 2075761 tttatcgaaa aaacggctat cccgatatgg tcaagcctgt tcattttcat ccctgctttc 2075821 gctaatagat atcgcttgtc cgcccattca aaacacgcta aaatatagac agattgttta 2075881 aggagtgaaa atcatgtctc aaaaactgat gaaaagcgtt ttgatcgtga ttttgggagt 2075941 ttttattctt tcaactgtac tctcaggaat cgtcatgttt ctataacgat aaaaaagcag 2076001 gcgccttatt caatgggaat atcctgcttt tttatcagag ctttatgctc gatggcaatc 2076061 tcctcaaaag agcggttgtc gtccgtgatc agcactctcg ttcctactgg tatcgtttga 2076121 aacaaatgaa caacctcatc gttatgcata cgtatacagc cgttagacac aaattttcct 2076181 actgattcct ctcggtttgt cccatgaatt ccataaatcc gcccgtccgt tcctttcgcg 2076241 tcaaatccga tccatcttgc cccaagcggg ttatcaggag atcccccttc aatatttttc 2076301 tttctgtagt aaggattttc cgcttttacc gttaccgaaa actctccttc aggcgtcaaa 2076361 tcatctgttt ttccagtcgc cacactatac acgccttcta ctttgttgtc gaggataaca 2076421 gcaagttcat ttgttcgctt gttgacaata acatacggat cacccggcag cggattttcg 2076481 ccgagcggcc aaatcggtga aatcatcatg aaaatcgaac ataagaaaaa acgcataagc 2076541 tcctcctttt tcattaggtt gaccaatgaa ggaagagctc atgcgaatca tccgagtgat 2076601 ttttgcgctt ttattccttt aaaataactt ttaatcacta aatattgttc catttcgccg 2076661 agaagatgga agagagcggc cctcgcttca aattcctctc tagtcgcagg aagcggcatc 2076721 tcctcaaatt cttttctcat gtcagcaagt cttttcagaa atttgtatgc tgtattccca 2076781 gggtgtatcg cctcccgcaa atcatgaata aattcagcga tcatttttcc ctgatctacc 2076841 gtgatggaga tcgatgtcac tttagggaga aggcgttcga taatttcaaa ttgcttttct 2076901 ctcattttaa aataatgata atgcagattt tcataacgca aaatgtggtt ttgcacatct 2076961 cgatatgcca ggtttttagc ctccgtaatg agctggtgcg tttccggaat ttcttttcct 2077021 gaccaatctt gctcaccagt taacaaatac cgttcgattt ctgcaaaaat gacagcaaag 2077081 ttatcctcta tctttttgcg gtaggcaatc agtttccggt caagactagg catatacaag 2077141 ttcatcaata gagcgacgcc gatgccaacc gtaatcagct gaacttcatt ccagatgaaa 2077201 gtaggcgtaa tgccgccgga catgtataaa tgaaggataa taacagaact ggtgacgata 2077261 ccctcgttaa tttttaacag aaccgttatc ggaatgaata tcaaaagaag cgctccgatc 2077321 acaaacgggt ggtagccaat aagctcgaaa aagagataag aaaaagcaat tgccagacag 2077381 catgccgaaa agcgggccca tgaggcctga agcgaccgtt tttgtgtgat ttgtatgcac 2077441 aaaatggtga tgattcctgc tgatgcgaag ttttgcaaat gcaataactg gcttatataa 2077501 atagccaaag ctgttccaag cgcggtcttt attgtgcggt aaccaatttt aaacatgtcg 2077561 gactccattt ctatttgttt cttcaataaa aaagaagagg cggccagcct tcttcttttt 2077621 tatattctat aatattttct ctaaaaagtc ctgcgctctt ttggattttg gcgacataaa 2077681 aaattccttc ggattgccgt cttcgacaat cattccttgg tccataaaca gcacacggtc 2077741 tgccacttct tttgcgaagc ccatttcatg tgtgacaatc accatggtca tgccggtttc 2077801 gaccagctct ttcatcacct gtagcacttc tttgaccatc tctggatcaa gggcggaggt 2077861 cggctcgtca aacagcatga tgtccggatt catcgcaaga gccctggcaa tcgcgacacg 2077921 ctgtttttgt ccgccagaca aacggtttgg atagtcattt cgcttttcaa acaaaccgac 2077981 tttgcggagc aggtcctcag ctttctcctg tgcagcctgt tttgattctt tttttacatt 2078041 gacaggcgcg tacatgatgt tttcgagaac cgttttgtgc ggaaagagat gaaaatgctg 2078101 aaaaaccatc ccgatgtttt cccggacctt taatgtgttg gttttcggct tcgtaatctc 2078161 tgtgtctttt attgtaatgg ttccgccgtt aggcttttcc aacaggttta aacagcgtaa 2078221 gaacgttgat ttgcctgagc ctgaaggacc gatcacggca acaacctcac cctcagcgat 2078281 tgttgttgaa atgtttttta atacttcgtg tttcccaaat gattttgaca gcttttcaac 2078341 cttaatcatt ggatttcagc ttcctttcta cagccttgcc gataaacgtt aaaatcagga 2078401 caagcacata ataaatcaat cccgcgataa tgagcggctc aaggtaattg taagtggcgg 2078461 cgccagcttg atatgcgcgt ctcatgacat caccaagccc gatgacggtg acgatcgccg 2078521 attcttttgt taacgtaatt aattcattca caattgcagg tgatatattt ttgaaggcct 2078581 gcggcagcag cagatccttc atcatttttc catacgggac accgagtgca acagcagctt 2078641 ctttttgccc tttatcaatg gcattgattc cggctctgat aatttccgat acataagcgg 2078701 cggaattcaa agacaatgcg acaaccgcag cccaaaactg gtcaatttga aatccgagca 2078761 gctgaggaag gccaaaatag acaatcataa gctgcagcac taaaggcgtg cctcggaaca 2078821 ctgatgtata aaaatcagcg atccagataa acgggcggaa tgtgctgatc ttgcataagc 2078881 ttagcacaat accgagtata agtccgataa tagcagatac aacaacaatt tttaatgtaa 2078941 ttgccaagcc ttctaatata aaaggaattt gggggatcgt tgctgaaaaa tccaaattca 2079001 tagcctttgt ctccttttct tacaggaaaa aagtttccta ttcaataaaa aggctcaacg 2079061 aaaaagttga gccgcttttt tttacttctc gccagtgaac cattttttct tcaatttctc 2079121 aagctctccg ttatcttcca tttccttgag cgctttattg aatttgtctg tcagttcact 2079181 gtcctttctg aaagcaattg ctgaaccggc ttcttccgct ttcgcatcag gaatcacaaa 2079241 gccttgcagg tcatcatttg atttgaaata cccttctgca acaatgtctt caataatcgc 2079301 ggcatcgaag cggtcagatt tgatttcctg caccaaatca gaaattctgt tgcggtcttc 2079361 tgttttaaaa ccatattccg gagaaagctc tttccccttc tcttcctgaa tagagccaag 2079421 ctgaacgcca actgtttttc ctttcaggtc tttcaaagat tgaatgccgc tgtctttttt 2079481 gctgacaatc atatggttcg ctgtgtaata cacatcggaa aaatcaactt gttttttacg 2079541 ctcaggcgtt ggtgtcattc ctgacagaac gagatccacc tgttttgatt taagcgctgt 2079601 aattaagctg ttgaagtcca tatcctgcac ttcaatttca tagcctgcct tctttgccag 2079661 agcttttgcc agctctacat caaagccgac aatattatct ccttctttat attcaaacgg 2079721 tttgtaatcc gccgaagtac ccataattaa ttttttcttt ccgctttctg aacctgaatt 2079781 gcttgagccg cacgcagtta atgcaaaggt gatgcaagca gccacaagta ataagagcca 2079841 ttttttcatg atccatttcc cccgtattca ttacttttgg tgtatttgaa tatttattcg 2079901 ttaatttgta ttttaaacag tttctcattt ttatgcaata ctatttttaa aaattatctt 2079961 taggcttatc tttccagtga tctcttctga tattactaga taaaaattaa atcgctgtac 2080021 aatccgattg aataatccct taatatttat tcatatatcc ttggaaattt atgcacaaaa 2080081 aaacccgggc tgctttgagc atccgggttg ttcgtcttat acttcttcac aatattcttc 2080141 aaaggcttcc tgcagctttg ccactacagc catcggctca tggccttcaa tttcatgacg 2080201 ctctaccatt ttcatgatct ttccgtcttt caaaatcgca aaggacggag aagatggtgg 2080261 ataaccttca aaatagtcac gcgcacgcgc tgtcgcttct ttatcctgtc cggcaaaaac 2080321 ggtgacgagc tgatcaggtc ttttatcata gtgaacggaa tggtaggctg ccggtcttgc 2080381 aattcctccg gcgcatccgc aaacagagtt taccatgacg agcgtcgttc cttttttcgt 2080441 aagtgcctca tccacctctt cggctgtttt aagctcggtg tatccggcag ctgttatttc 2080501 ttgtctcgct tggcggacaa tatcattcat aaataaatta aagtccatgt tcaatgaaga 2080561 cctctccttt ttcatcatct gttcttatga tagcaaggaa acgtccatat cggcaaatga 2080621 ctttgcttcg ccgtgcactt tttttgctct tcgtttactg cttacagaaa aaggggatta 2080681 tataaccaga agtaaaataa aggagcagtt gtatatgagc caccggaaag cgttactgat 2080741 tcataacgga aatgccggca acaaaaatat agaaaaagca cttggtgctg tggtgccggt 2080801 tttatctcac catttagatg aggtgattat taaacagaca aagaaaaagg atgatgcgta 2080861 tcatttttgc cgatccattg atgattctgt cgacaccgtc ttcattctcg gcggcgacgg 2080921 cacgatccat caatgcataa atgctatcag cgctctagaa agaaaacccg ctgtcggaat 2080981 tttgcccggc ggcacgtgca acgacttttc aagagtgctt ggcatccctc aaaatcttgc 2081041 aaaggccgcg gaagcactta tggcgggaaa aaaaaccagc gtagacgtat gtcagatgaa 2081101 tgaccgttat tttttgaatt tctgggggat cggcttaatt gcagaaacgt cgaatcaaat 2081161 caacgaaacg gaaaaagcat tattgggaaa aatcagctat tttacaagtg ccttgcgaac 2081221 cgtctcatct gctgcatcgt ttccgatgac attaaaaatt gatggagaag aaattaaaga 2081281 agaagccgtt atgctgcttg tgatgaatgg ccaatacatt ggaacgaatc gaattcctct 2081341 gcccgatgcc agtattgaag acggcttact tgatgttctc atatgccgca ataccaacct 2081401 caccgcgctg cgggagctga tgagcatgga acaaggctca attgatcgtt ttactggaga 2081461 gttgtcctat gtccaggctt cccgtatcga gattgaaaca gacactgcca aaaaggcgga 2081521 tatggatgga gaagtttata cacatacacc cgcagtcatt caggtcctgc cacagcatat 2081581 cgacatgctt gttcccgcaa atgaataact gtcataaggc tttagaaaga ttttgcaaat 2081641 ccgttgactc tcccctagga ggaggtctta cagtataagg gatacacact tgaaaaaggg 2081701 gaagtcatat ggagaagaaa aatattacct taactatatt attaaccaat ttatttattg 2081761 cttttttggg gatcgggctt gtgattccag taacgccgac cattatgaat gaattgcatt 2081821 tatcggggac cgcggtcggc tatatggttg cctgcttcgc tattacacag ctcattgtct 2081881 caccaatagc cggacgatgg gttgatcgct tcgggcgcaa gatcatgatc gtaatcggcc 2081941 tgttgttctt tagtgtgtcg gagtttttgt tcggcattgg aaaaacagtt gagatgttat 2082001 ttatctcccg tatgctgggc ggtatcagcg cagccttcat tatgcccggg gtcacggctt 2082061 ttattgcaga tatcacgacc attaaaacac ggccaaaagc gctcggttat atgtcagccg 2082121 ctatttcaac aggatttatt atcggccccg gcatcggggg atttttagca gaagtccatt 2082181 cccggctgcc ttttttcttt gcggcagctt ttgcactgtt agcagccatt ttatcaatcc 2082241 tcacgctgcg cgagccggaa cgaaaccctg aaaatcagga aataaaagga cagaagacag 2082301 gctttaaacg aatttttgcc cccatgtatt tcatagcttt tctcattatc ttaatttcgt 2082361 cttttggttt agcatcattt gaatctttat ttgcattatt cgtggatcat aaattcggat 2082421 ttacggccag cgacattgcc attatgatta caggaggagc gattgttggc gccattacgc 2082481 aagtcgtctt attcgaccgc ttcacaagat ggtttggcga aattcattta attcggtaca 2082541 gcttaattct ctcgacgagt ctggtattct tgctgacaac ggtacattca tatgttgcga 2082601 ttctgctggt gacagtcacc gtatttgtcg gatttgatct catgcggcct gcggtaacga 2082661 cttacctgtc aaagattgcg ggaaatgaac aggggtttgc cggcggtatg aattcaatgt 2082721 ttacaagtat cggcaatgta ttcgggccta ttatcggcgg aatgctgttc gatatagatg 2082781 taaactatcc tttctacttt gcaacggtca ccttagccat agggattgca ctgaccattg 2082841 cttggaaagc gcctgcacat cttaaagcca gcacgtgata agaagcgcat tctttgtgta 2082901 ctgcaaagaa tgcgcttctt ctttatactg atgatagaag gagtgatggc atgaaggaat 2082961 cgtattactc aattggggaa gtatcaaaac tggcaaacgt gtcgataaaa gcgctccgtt 2083021 attacgataa aattgattta tttaaaccag cctacgtcga cccggatacc agctaccgct 2083081 attatacaga ttctcagctc attcatctgg atttgatcaa atcattgaaa tatatcggca 2083141 cacctttaga agagatgaaa aaagcacagg acttagagat ggaagaactg tttgcttttt 2083201 atacagagca ggagaggcaa atcagggaga aattagactt tttatcagcc ctggagcaaa 2083261 ccatttcatt ggtgaaaaag cggatgaaac ggcagatgga atatcccgcg ctcggtgagg 2083321 tgtttgtttt agatgaagaa gaaatacgga tcattcagac agaggcagaa ggaatcgggc 2083381 ctgaaaacgt gctcaacgcc tcctacagca aattaaaaaa atttatcgag tcagcagatg 2083441 gatttacgaa caatagctac ggcgctactt tctcttttca gccctacacc agcattgatg 2083501 aaatgactta ccgtcatatt ttcacacctg tattgacgaa taaacagatt tcatcaatta 2083561 cgccggatat ggaaatcaca acgatcccta aagggaggta tgcgtgtatc gcgtataatt 2083621 tttcgcctga acattatttt ctcaacttac agaagcttat caaatatatc gcggaccgcc 2083681 aattaacagt tgtcagtgat gtatacgagt taatcatacc gattcattac tccccgaaaa 2083741 aacaagaaga atatcgagtc gaaatgaaaa tacggatcgc tgaataataa agcatagaaa 2083801 aagagcattt tttgaaacaa aacttcaaaa aatgctcttt ttgcttattt agtaaacaga 2083861 tgtcttctcg tcaatcgatt ctaaaatttg tttcactcgt ccgaggaatc gtccgcacac 2083921 gagaccgtca agcactctgt gatctaatga caggcacaga ttaaccatgt ctctgacagc 2083981 aatcatgcca ttgtccatga caaccgggcg tttgacgatg gattctactt gaagaatcgc 2084041 agcctgaggg tagttgataa tgcccatcga ctgaacagac ccgaacgaac ctgtgttgtt 2084101 gacggtaaac gtgcctccct gcatgtcatc tgcagtgagt tttccgtctc ttactttttt 2084161 agctaggccg gtaatgtctt tcgcaatgcc tttaattgtt ttttcatcag cgtttttaat 2084221 caccggaaca aataaagaat cctctgtggc aactgcaatt gaaatattga tatccttttt 2084281 ctgaataatt ttgtcccccg cccacatgct attcatttgc gggaattctt ttaacgcctg 2084341 agcgaccgct tttacaaaaa aggcgaagaa cgttaaatta aagccttctg tcttcttaaa 2084401 agaatctttt atactgttgc gatatgcaac catatttgtg acgtcgactt ccatcatcgt 2084461 ccaagcatgc ggaatttctg ttttgcttcg cttcatattg gaagcaattg cttttcttac 2084521 acctgtgaca gggatttctt tatcaccggc tgcagacgca ggatatgacg tctcttcttt 2084581 tggctcaggt tttgatgcag acttcggtgc aggagctgct gttttcagct cctcaggatt 2084641 ctgttcttgc acgccgcctg tttcaattaa gcgctgaata tcttttcgtg tgatgcgccc 2084701 gccggcacca gttcctgtca cttgatcgag gtcaatgccg tgctctccgg ccaaacggag 2084761 aacagctggc gagtagcgct ttttattggg ctgatcggct gctccagcac tttttgcaac 2084821 agggttctca gcggcttctg atgctgctgg ctgttcttgt ttttgttcag ccggattcgc 2084881 gccttctgtt tcaattttgc aaatcatttc tccgacttgc agggtttggc cttcttctcc 2084941 cacaagctct gttatcgtac cagtaaaaga agacggaacc tctgcattta ccttatctgt 2085001 catgacttcc gcgatcggat cgtatttgtt cactttatca ccgggggcga caagccattt 2085061 gctgatcgtc ccctctgtta cgctttctcc aagctgcggc atcgtcattt gttcaattgc 2085121 catgattgta tcctccctta cgtctttaaa actccgctaa ttctctcatc gccgcttcca 2085181 ctttatcagg gttgaccata aagtattttt ccattgtcgg cgcataaggc atagccggaa 2085241 tatcaggacc tgcaagccgt ttgatcggcg cgtctaagtc gaacagacaa tgctcggata 2085301 taattgcggc tacttcgctc atgatgctgc cttcttttgt atcttctgtg accaaaagaa 2085361 cctttccagt tttggacgca gcttcgatga tggcttcttt atcaagcggg taaactgttc 2085421 ttaaatccac cacatgcgct gaaatgccat ctttttcgag acgttctgca gcttgtaagg 2085481 cgaagtggac acacaggccg tatgtgatca ctgtgatgtc gtcgccttcc ctttttacgt 2085541 ccgccttgcc gattggcagg acataatcat cagccggaac ctcgcccttt atcagacggt 2085601 atgcccgctt gtgctcaaaa aacagcacgg ggtcttcgtc acgaactgcg gcttttaaga 2085661 gccctttcgc gtcatatggt gttgatggca tgacaatttt cagtccgggc tggttggcga 2085721 aaattgcttc gactgattga gaatgataca gggctccgtg cacgcctccg ccgtatggcg 2085781 ctctgacgac aatcggacag ctccagtcat tgttgctgcg gtagcggatt ttagccgctt 2085841 cagaaataat ttggttgact gccggcataa tgaaatcagc aaactgcatt tcagcaatcg 2085901 gtctcattcc gtacattgcc gctccgatac cgactcctgc gattgcagat tcagcaagcg 2085961 gcgtatccat aacgcgctct tccccaaatt gttcatagag tcccgctgtc gctttaaaca 2086021 caccgccttt tcttcctaca tcttccccaa ggacgaaaac gcgagaatct cgttccattt 2086081 cttctttcat cgccaaattg attgcatcaa tatatgacat tactgacatt tgttcttcct 2086141 ccctacttcg cataaacata atcaagcgct gactcaggag ctgcatatgg ggcgttctcc 2086201 gcttcatccg tcgcttcatt tacgattgcc ataatttcat ccagcatggt ttgttctatc 2086261 tcatcggaca gcaggcctgt ttcctttaag taagcttgat aagtaagcag gggatcactt 2086321 tttttcgctt cctctacttc ttcacggcct ctgtagctgc tgtcatcgtc atcactggaa 2086381 tgtggtgtaa ggcggtaaga aatcgtttca attaatgtcg ggccttctcc tctgcgtgcc 2086441 ctttcgcgtg cttctttaac cgcttgataa acttccagcg gatcatttcc attcacagtt 2086501 acgccaggca tcccatagcc tatggcacgg tcggaaatgt tctcacatgc gacttgctta 2086561 tcgtaaggca ctgagattgc gtatttgttg ttttcacaca tgaaaataac cggcagctta 2086621 tggacagcgg caaagtttgc cccttcatgg aaatcgcctt ggtttgaaga cccttccccg 2086681 aatgtaacaa aggctgcgat atcctttttc tccatacgtc ccgcaagcgc aataccgact 2086741 gcgtgcggca cttgcgttgt aaccggagat gatcccgtca caatgcggtt tttcttttgt 2086801 ccgaaatgtc ccggcatctg gcggcctcct gagttcggat ctgctgcttt tgcaaacccg 2086861 gacatcatta agtcctttgc tgtcatgcca aacgcgagca cgacacccat gtctctgtag 2086921 tacggcaata cataatccat ttcacggtca agtgcgaaag ccgctcctac ctgtgctgct 2086981 tcctgtcctt gacaagagat tacaaatgga attttgccag aacggtttaa cagccacatt 2087041 ctttcatcga tttttcttgc taacagcatg gttctataca tatcaacggc ttcctgatca 2087101 gtcagcccta gtgcttgatg tcggtttgta ctcattcaag cccctccttt atgcttttaa 2087161 aaatgaatgg ctttgccatc tgcggcaagc gcagcttctc caattgcttc agaaagcgtt 2087221 ggatgcgggt gaatcgtttg cccgacctcc cacggtgttg cgtccagcac tttggcaaga 2087281 cccgcttcag aaatcatgtc ggtgacatgc gggccaatca tatgaacgcc gagaatatca 2087341 tctgtatctc ggtcagccac gattttgaca aaaccgtcgc tttcaccgta tacaagcgct 2087401 tttccaatcg ccataaatgg gaacttgccg attttgacat tatgcccgtt cgcctttgct 2087461 tcgtcttcgg ttaagccgac actggcagct tcagggcttg agtaaatgca cttcggcaca 2087521 agcgtcggat caagcggatg cggattgaga cctgcaaaat gctcaacagc aataattccc 2087581 tcatgtgaag caacgtgagc taactgcagg ccaccgatta cgtctccgat tgcataaata 2087641 tgagattcct tcgtttggca gctttcattg actgaaatca tgccattttc agtaacaata 2087701 tcggtgttct ctaggccgat gccttcgata tttgcctgtc tgccgatgga aacaagcatt 2087761 ttctcagcag aataggtaac ggtttctccg tctttttccg cttgtatgct gatatcgtct 2087821 gatgtttttg tcattgtgtc aggcagcact tttgcccctg ttatgaactg gatgcctttt 2087881 ttcttaagaa gactttccat ttcttttgaa atctctagat cttcagtcgg caatatgcga 2087941 tccgcgtatt caataaccgt taccttaacg ccaaaatcat gaagcataga cgcccattcg 2088001 ataccgataa cccctccgcc gacaatgatg attgactgtg gcagctcctc catttggagc 2088061 gcctcatctg aagtcagtac agacttaccg tccacttcaa gacccggaag cattctcggt 2088121 cttgatcctg ttgcaatgat cacttgtttc gggatcagca tgtcattttc ttcgccattt 2088181 ccccgctcaa cagaaattgt tcccggcagc ggagagaaga ttgacggtcc aaggatacgt 2088241 ccatatccgg tgtacacgtc aatttttcct tttttcatta aatgatttac acccgctgca 2088301 agcttatcaa caacggcttg cttacgctgc tgcacttttt caaagttgag ggacacgcca 2088361 gccgtttcca ctccgaattg atcggcttca cgagctgtcc ggtatacctc tgcgcttcta 2088421 agcagcgctt tactcgggat acagccttta tgcagacatg ttcccccgag tttttccttt 2088481 tccacaacgg ctgtttttaa gccgagctga gcggctctga tggccgcaac ataaccgccg 2088541 gtaccgccgc ccagaatgac tacgtcatac tcagttgcca tggtgactca ctcctgtctg 2088601 tctattcaat acgatattgt ttggattgct cttcgccctg caatactctt agcgcccctt 2088661 gggcaagaga ctgcagttca ttttcacccg gataaactaa aacgtctgaa atccaatcta 2088721 tgtatgatct gatagcagaa acaaagcttt ttccgtacgc aaggcctccc gtcagcacaa 2088781 tcgcttcaac ttcgcctttt aacgccgcgc tggctgcccc gatttccttt gctacctgat 2088841 atgccatggc atcataaatg aagcgggctt tttcatcgcc cccttgaatc atctgttcca 2088901 cttttactgc atcatttgta ccgagatagc ctaaaagtcc gccggtgcca acaagctttt 2088961 tcatgatttc ttcttttgta tattcccctg aaaaacatag atcaacaaga tctcccgcag 2089021 gcactgttcc tgctcgttca ggactgaatg gtccctcgcc gtgcaggccg ttattgacat 2089081 ccaccactcg cccgcggtca tggacgccaa ttgtaatacc tccgcccata tgggtaataa 2089141 tcattttcat gttctcatat cgtttgccaa gggaggctgc cgctttacga gcgacagctt 2089201 tttggtttaa cgcatggaaa atgcttttcc tttcaatttc aggcatgcct gaaactttcg 2089261 caagcactga catttcgtct acgacaacag ggtcgacgat atacgaaggg atattcaggc 2089321 cgtcagcgat ttcccgcgcg ataatgccgc cgagattaga agcatgctga ccggcgtagc 2089381 cgcttttcaa atcctcaatc atctcatcat tcactacgta ggtcccgcct tcaattggcc 2089441 ggagaaggcc gcctcttgcg cagactgcat caaactttga aatattgatt ccctgttcat 2089501 gaagcgtttc gagaatatgg tttttacgaa attcatactg atcaataatt cggtcaaatc 2089561 gctgcagctc ttctatgttg tgtctcaatg ttttttcaaa aatgcttctt tcgttatgaa 2089621 aaacaccgat tttcgttgaa gttgagcctg gattaattgt gagaatgcgt ttttcgtcat 2089681 gtagcacttt cataacctcc agatcaattt cttaacgtct gcttaataca ctgtggccgt 2089741 tttgcaaaaa ctggcttctt gagcggcgca tgcgttcaat ccgttcctct gctaagcggt 2089801 cagccgctaa atatgcagga atgccgtcac gctgagaaat ctcaagtaca cgctcgatat 2089861 tgccgtaaat gccttcaact tttttcaatg cacgttctgc attatagccg taaagctcat 2089921 ctgccacgtt gatgacaccg cccgcgttaa tcacgtaatc cggtgcataa acgatgccca 2089981 tttcgtgaat ttgatcacca tggcgtgtct cttttaattg gttgttagcc gcacctgcga 2090041 tcactttcgc cttcagctgt ttaatggtgt cgtcgttaat agtcgcacca agggcacacg 2090101 gcgcataaat atcgcagtct tgtgaataaa tgtcatcagg atctaccgca cgggcgccaa 2090161 aatcttcaac tgcacgctgt acagattgtt tgttgatatc cgtaacgatt aagtttgctc 2090221 cttcttcatg caggtggcgg caaaggttat aggctacgtt cccaacaccc tgtacagcaa 2090281 tggtttttcc ttcaagagag tcggttccga aagcagcttt agctgctgcc ttcattcctc 2090341 tgtacacccc gtacgctgtg actggggacg gatttccaga agagccgaaa gcaggagaaa 2090401 tccctgtgac atagtctgtc tcatcatgaa tgatatccat atcctcgacc gttgtgccca 2090461 catcttcagc cgtgatgtat ctgccattca gtccttgaat atagcggcca aacgcgcgga 2090521 acatttcctc atttttgtct ttgcgcggat cgccgataat gactgttttt ccgccgccaa 2090581 ggtttaagcc tgccgccgcg ttcttatagg tcatgcctct tgccaatctg agcgcatctt 2090641 caattgccgc ttcttcattt tcatatgtcc acattctcgt tccgccaagc gccggaccaa 2090701 gcgttgtatc atgaatggcg ataatcgctt ttaatccaga ttgttcatcc tggcagaata 2090761 ccaattgttc gtaatcgtat ttctccatat atttaaaaag ttccatgttc gttcctccta 2090821 atgtgtgtat tcttcagatg cgcatattgc cagcgcaatg gaatacagtt tattttcagc 2090881 agagtccgct ctgcttgtta aagcaatcgg tgcttttgct cctgtaatga cagccgccac 2090941 gctggccttg gcaaaataaa tcagtgattt atataaaata ttgccggcct caattgttgg 2091001 gacgagaagg atatctgcgt tgcccgctac gtctcccgaa atttttttct gggccgcggc 2091061 aatttgtgaa actgcgttat ccaaagcaag cggtccatca acaatgcagc ctttgatctg 2091121 gccccttttg tacatttgag ctagagcagc tgcattcacg gtcgcttcca ttttagggtt 2091181 caccgtttcg accgctgcaa gggcagctgc ttttggcata ttgttcccca ctgcatgggc 2091241 cacatgaacg gcattttgca aaatctgccg gagctcttcc agcgaaggag caatattcat 2091301 tgccgaatct gtcacaaaca tcagccggtc aaaatccggt atatcgaaga cagccacgtg 2091361 agaaaggaca cttgctgacc gaagcccctc ctgtctgttc aataccgctt taagcaaaac 2091421 agaagtcggc acattgcctt tcattaaaac gtccgctgtt ttatgatgca cagcacgaac 2091481 cgctaatttc gccgattcct caggagtatt ggcatggacg atttccactt gatgcccttg 2091541 catggatgat gtcagctcgt tcagtttttt gctgtcgccc gttaacaaga aacgggcgga 2091601 taggtgctcg gctgccagct ttacagcccg gatcacttcc tcatcctcag catgagcaac 2091661 cgcaatggtc ttatttttgt gtatcgacgc tttgccgatt aaatctttca gcttcatctg 2091721 ttaccacctt tcttgtttcg actccgcctt ttattatgca agttccatgc cagctcttaa 2091781 gggtgctgtc ataccaggta taccgaaaca ttcgtgcaga tgtttgcgtt tattctgcaa 2091841 attattgcat gccttcattt gcaaggccat atttatccat tttgtaatat aaattccgaa 2091901 tgctgacacc gagagctttt gctgtttttg tccggttaaa atgatgcttt tcaagcgttt 2091961 gctggatcaa atgcgcttca aatttttcta ctgcgacaga cagcttttcg ccttcaatat 2092021 ccggaaaatc aaaacctgtt ccctgatctg tgtcattttc tttttgctca agttcgaata 2092081 caggcaagtg atctttttca atccattcca tatgcggatt cagaaaaatc atggctcgtc 2092141 caaggacatt ttcaagctcc cggacattcc caggccaatg gtaggcagat aaggcgcgca 2092201 aggcttgctg tgagagccct tttacattcc tgccgtaatc ccggttgatc ttttggataa 2092261 gtctgacgct caatgcttca atgtcctcca accgctgccg caaaggcggg atggagatcg 2092321 gatagcgatt gatccggtaa tacaggtctt cccggaatgt tccgtccgcc atcgcctttt 2092381 caatatttac atttgtcgcc gcgatcactc tgacgttgac agggatcgct ttcgtgccgc 2092441 ccactctgac gatttccttt tcttgaagga cgcgtagcaa tttggcctgc atattttgtg 2092501 tcagctcacc gatttcatct aagaaaatac tgccgttatt tgcttcctca aataaaccct 2092561 ttttaccgcc gcgcttcgct cctgaaaacg caccatcctc atagccgaac aattctgatt 2092621 cgagcaggtt ttcagaaagg gctgcacaat tcacgcgaat aaatttattg tatttccggt 2092681 cactttcgtt atggatggca tgggcgaaca gttcttttcc tgttcctgat tccccgcgca 2092741 gcaagatggt tgccggtgtt ttcgcaccga gcttcgcctg ctcaagcgca accagcattt 2092801 gctcgctttt gccgataatg tcgtcaaacg tgtatttcgc ttcaagcgtg cgaataattt 2092861 gtctggcgcg attaagctcc gctgtcagca ttttaatttc ggaaacatcg tgaatcacgc 2092921 cgacgctgcc tttcaaaatc ccgtccacaa tcaccggtgc tacattaacg atcacttctt 2092981 tttcattcgg gccgaccttc attctgacac cgcggacagg acgtcttgtt tcaagcacct 2093041 ttaaatgcat gctttcgcct tcggaaatat cagtgtttgc aggcttgccg atgacttctt 2093101 tttcagaaag ccccgtcatt ttcgtatacg ctttattgat tagcaggccg atgccgtttt 2093161 catcaacgac agaaatcgcc tcatcggagg attgaataat tgcctccagc atcgtacgga 2093221 cctgctttaa gttggtcact tcctctgcca gctcgaccgc atcagtgata tctttaaaca 2093281 cacaaagagc cccgagcaga cgtccgcctt catcaataat cggcagtctt gtggtcacaa 2093341 tttgcaaatg atcgcctaac agctgcttct ggttgtattc aggcactctt gtttttaaaa 2093401 tccgcggcat cttagtgctc ggaatcactt cttttattgg gcgcccaatg acttcctcac 2093461 gtttttttcc gaccattttt tcggccatat ggttaaagag aatgatttct tcattgatat 2093521 caataaaaat cattccatca tgggtggaat taaaaattct gtcatattta taggtttgct 2093581 cttttagcat ttgaatcagg tgctgctttt cttccatcag ctgaaaaacg atgtatgcca 2093641 tttttcccgg catgacaatg gtatcttcat gctttctttg aaggagctcg tcaaacacgg 2093701 cttgatcgcc ggtagtatga atgacgatat ccggtttttg ttgtatgtaa ggtttccaat 2093761 cagatgatac ggcaatccca tactgttctg cttctttcaa tcccggcgcc tcggggtctt 2093821 tgtcaactac ggcaatgata tctatgatgg ctgttttaat cagaatatgt aataacgccg 2093881 ttcccctttt gccggcacct actatcagta ccttttgcat cccgataccc ctttgtatga 2093941 aaaaatttgc acacctattt attccgttgc aataatttgc acaaccctat gttaccacgt 2094001 tttcttctct tgacaaaata ttttttccgc tggacaataa aggaaatgaa aagataaagg 2094061 ggttttctga agatgagccg acttcttgcg cttttaatat tagtcatccc cggggctatt 2094121 tctgctttag gcattaaact gatgagagat acacttttcg gccatacaat caagccattt 2094181 tcagctcttt ggctccaagg gttgtcagga ttcatctttt ttgcgatcgg cctctatgtg 2094241 ctggccgggt tcattttata cagagacaga aaacgcaatc aagtcagccc gcgattcaga 2094301 aaacgatagc tgaaaaaaag ccggagaatg ctccggcttt ttttgttgca ttattcgtca 2094361 ggcaaaacgg tcttggcaat cgttttgtct aacgcttcat agtcataata agaaatcgta 2094421 tcgtacagtt cttttcgtgt ctgcatatca tgaagtcctt ctttttgtga gccgtgctcc 2094481 ttcatcaaac caaacatccg ctcacaagct tttgccgccg ctcgaagcga ggtgacagga 2094541 tatatcacca tgtgaaaccc catatcttcg aattcatcgg cacgataata tggcgttttc 2094601 ccaaattcag tcatattcgc aaggagcgga acggggatac gctcagcaaa ctggcggaat 2094661 tcattctccg cctgtagcgc ttccgggaaa attgcgtccg ctcccgcctc aatgtaagcc 2094721 tctgaacgtt ttattgcggc atcaagccct tcctgcgccc tggcatcagt acgggcaaca 2094781 acaataaggg agggtgccgc ttgtttaatg gcttttattt tttgcgccat ttcctttatc 2094841 ggaactagct gtttgccatt taaatgtccg catttttttg ggagctgctg gtcttccatt 2094901 tgaacggctg ctaccctggc ttcaagcatc tcccgggctg ttcgggcggc atttaagaca 2094961 ccgccaaatc ccgtatcgat atccacaagc aaaggcagat cagctgcacg cacaagatct 2095021 ttggcccgtt cagctatctc tgccgatgtg atgatcccta aatcaggcag ccccctgctg 2095081 gctgtatagg cagcaccgga caaataaata gcagaaaaac cggcttcttt cgcaagcaaa 2095141 gcggccatcc cgtcatgggc gccgggaatt tgaagaatgt ccggtgctga catcagcttg 2095201 cggaaacgcc cggcaagctc ctcttgtgac gattgcttat tgacgatcca cgacatgaaa 2095261 caaaatcccc cttttacatg cagaacatgt ctacgaattc atttacgcgc atcgtttgta 2095321 atgtctcata gctggtacag cgctcataaa tgtgtttgtg ctgtttatca ggaaaatggg 2095381 ttttgagatt gtcagaaaac ttttccagca gtttcggcac tgcttcctct cttcgaaaac 2095441 gatggccgag gggaaactca cattccacca tttccgtgct cgttccatct ttaaaatgaa 2095501 cctgaacggc atttgagatg gagcgtttat caggcttcaa ataatcctcg gtatatgttt 2095561 tattttcagt cacttccatt ttatcacgaa gtttatctat tctcggatca ttcgctgttt 2095621 cagcttcata atgctgtgcg gtgatatcac caaaaagcaa accgattgct gtaatgtatt 2095681 ggaggcagtg atcacggtct gccggattgt ggagcgggcc ttttttatca atgattcgga 2095741 tagctgattc atgcgttctg atgacaactc ggtcaatctc gtcaatccgg ttctttacct 2095801 gcgggtgaag aatgacggcg gactccgccg ctgtctgggc gtgaaattcc gcaggataag 2095861 acactttaaa taacacattt tccatgacat aagcgtcgag cggacgggca agcttgatct 2095921 ctttcttatt gaataaaacg tcttggaacc cccaacccgg tgcactcaag gctgtcggat 2095981 aacccatttc cccttttaac gacatcagcg ccaaatgaac acctctgctc gttgcatctc 2096041 ctgccgccca tgatttacgc gagcctgtat tcggtgaatg gcggtatgtc ctcaatgctg 2096101 cattgtcaat ccatgcattc gaaagcgcat ttttgatttc ttctcttccg ccgcccaaaa 2096161 gctttgctgc aacagcagtt gtcgcaactt tgacaaacag cacatggtca aggccaactc 2096221 gatttaagct gttttctaac gccagcacac cttggatctc gtgtgctttg atcatcatct 2096281 caagtacgtc gcgtaccgtt aacggctctt ttccttcaga cagcctcact cttgatacat 2096341 aatcagcagc ggcaaggatt cctcccaagt tatcggatgg atgcccccac tccgccgcca 2096401 gccacgtatc gttgtaatcg agccagcgaa tcatgcagcc aatattaaac gctgccctca 2096461 caggatcgag aacatatgac gttcccggca ctttgcttcc attcggcaca gtcgttcctg 2096521 gaacaatcgg gccaagcagc tttgtgcatt ccggataccg tagcgccaag attccgcagc 2096581 ccagggtatc cagcaataca tgccccgctg ttgtatacgc ttcggcacta gtaatctctt 2096641 tctcaagcac atagtctgtg atttcttcga taacacgatc cgttttcggc attctaccag 2096701 ctcctttcat gattttgttt gatatcgcgg gcccatgtaa ctgacacggg gacggaagag 2096761 ccgattattg gcatgctgtt cgatcacatg ggcgcataaa ccggacgttc tcgcgctgaa 2096821 aaagatcggc gtatataaag gaatcggtat gccgagcatc caatacactg gggcagcata 2096881 gtaatccaaa ttcgggtaaa gccctttttc cttctccatc agccgctcac ccgcttcgca 2096941 catctcatat aaacgatggt caccggcttt atcgcataat tgctgcagcg cctctttcat 2097001 catgagtgct ctcgggtcca tttttttcat atacacccgg tggccgaagc ccatgatttt 2097061 ttcttttctt ttcagttttg tttgcaaaag ctgctcaaaa tcagatgtcg tttttgcctc 2097121 caaaagcaaa tacatcacag cttcgtttgc tcctccgtga agattccctt tcagggaagc 2097181 gacagcccca gtcaaagccc cataaagatc tgaatgtgta gatgcaatga ccctggccgc 2097241 aaaggttgaa ttcggcatct catgctcact gtacaggacg agcgaccggt caaaaatctg 2097301 ttcttccaat gaagacggca atttccctgt catcatgtag agaaaattcg cactgtagga 2097361 tagggtttga agcggaagaa tcggttcttt cttattaatg atcctgtagc tggcagcagt 2097421 gagggcaggc attttcccaa gaagctgata ggcgcgttct ttgtttgcgg aaggagaccg 2097481 atcatcaatt tgccgatcat agccagcaag tgccgacagg ccggtacgca gaccatccat 2097541 tggatgagtg tcctcaggga gcagctcaag cagacggaga tgatcagcag gcaggcttga 2097601 ggcactgttt attttacgtt ccagcgtttc catttcactt tcttctggca gcctgccctc 2097661 cagcaataaa tggacaagct ccagatagct ttttgtttca gaaagttcta ttaaatcata 2097721 gcctcttatc aaaatctggc tggactgcgt gtcaagataa gaaatatgag tttctgccgc 2097781 aatcacaccg tccaaccctg gagaataatg ctgtttctcc tccatatcct caacctccgt 2097841 ttttgcgttt tttgtctatc aggttccgcc aagcaaatac ttggaaataa tcagtctttg 2097901 aatctcgttc gtcccttcat aaatttgcgt cacctttgca tcgcgaagca ggcgctcaac 2097961 tggataatcc ttcatatagc catatccccc ataaatttga acggcgtcta acgccgcctt 2098021 tacggctgca tcggaagcaa attgtttagc catagacgct tcttttccac agtttaggcc 2098081 gcggttatga aggtctgcag cgtggtagac aagatgtctt gccgcctcag ctctagtcgc 2098141 catatcagcc agcttaaatg atatgccttg attggctgca atcggccttc caaattgcac 2098201 tcgctgcttc gcataatcaa cggcatgctc aagagccgcc tctgcaattc cgagggcctg 2098261 tgccgcaatg ccgatccggc cgacatttaa attcgccatg gcaatgtgaa agccatcccc 2098321 ctctttgcca agcaaattgg cttcaggcac ttctgcatta tcaaaaatca gttccgtagt 2098381 attggagcca taaagcccca gctttctttc tttttttcca acggtaaaac cgggtgtgtt 2098441 tttttcaaca ataaaagccg aaatcccgtg cctgccttga tctggagctg ttaaagcaaa 2098501 tgtgatatag atatcagctg ctccgccatt cgttatgaat attttcgatc cgtttaatag 2098561 gtatttgccg ttctttttga ttgctgttgt gcggaggctc ccggcatccg accccgagtg 2098621 aggctccgtt agtgcaaatg cgcccaaatg gtctcctgac gcgagatttg gtatatattt 2098681 catcttctgt tcttcgttgc cgaaatacag aatcggattc gtgccgactg aggtatgaac 2098741 ggagagaatc acgccgacag ccgcgctgat tctagaaatc tcatgaattg ccaaaatata 2098801 agaaacaacg tccgctccag caccgccgta ttgttccggc accggtattc ccatcagtcc 2098861 gtgtttaccc atttttttga tcagctgaaa gggaaattcg tccgttttct ccatgatttc 2098921 cgcagcggga gcaatttctt ttcgtgcaaa atcacgcacc atttttcgca tcatgacttg 2098981 ctcttgggtt acatgcaact cggccacccc cggatggaat agacttcagg aagtcttctc 2099041 ctcatagtca taaaaaccgc gtccgctctt tttgccaagc cagcctgctt tgacatactt 2099101 gcggagcagc gggcaaggac ggtatttgga atcgccaagg cctgagtgaa ggacttccat 2099161 aattgataaa cacgtatcca gtccgataaa atccgctaat gcaagcggac ccatcggatg 2099221 attcatgccc agcttcatca cttcatctat tgcctccggc ttcgccactc cctcatacac 2099281 gcaatagatg gcttcattaa tcattggaag aagcacacgg ttggaaacaa acccaggaaa 2099341 atcattgact tctaccgctg ttttccccat cttttccgct aatgccataa catctaaggc 2099401 cgtttcttct gatgtagcca agcctcgaat cacttctacc agcttcatta cagggacggg 2099461 attcataaaa tgcatgccaa taacccgttg aggccggttt gttacagcag cgatttctgt 2099521 aataggcaag gaagatgtat tgctggccaa aatcgtatga ggcgggcaaa tgcgatcaag 2099581 tgttttaaac atctcagttt ttgccgccat gttttctgcg atagcctcaa tcacaatgtc 2099641 cgcatgctct gcctcctcaa gtgtttgaga aatcgaaatg cggttgatta cgctcttcac 2099701 ttccgtctcg gtcctttttc ctttctcagc atcacgggcc agctgtttct tcagccgttt 2099761 caatcctgcc tccgcggcct ctggattcac atcatacatc cgcacataaa agcccgcgtc 2099821 ggcggctgtt tgagcaattc cgctccccat ctgacctgcg ccagctacca tgatttgttt 2099881 gatttccatt caaatcccct ttttcatcat gttttaatga acctgcacta agacggcgtc 2099941 tccctgtgct gccccgctgc aaatagcggc aacgcccaga ccccctcccc gtcgctttaa 2100001 ttcataaaca agcgtcatga gaattctcgc accgctcgcg ccgatcgggt ggccgagcgc 2100061 gatcgcaccg ccattcacat ttactttttc aagatcgaaa cctacgattt tttcacatgt 2100121 caaaacaact gaagcaaaag cttcatttac ttcaaacaag tcaatatctt ggacagttaa 2100181 accattcttt ttcaggagct tgttaatagc aaaccctggc gctgccgcca gctcgtgcgc 2100241 tggcattccc gtagttgaaa aaccaagaat tgtagccaga ggccgtttgc caagctcagc 2100301 agctttttcc tcagacatca gcacgaacgc gccggctccg tcattgactc caggagcatt 2100361 gccggctgtg atagaaccgt cacttgcata aatcggagca agttttgcga gctgatccag 2100421 acttgtgtca cggcgaatcg cttcatcttt atcaacaacg tttggttttc cttttcgacc 2100481 gatccagttg acgggaacaa tttcatcctg aaacttccct tcatcggcgg ccttagctgc 2100541 ccttgcatga cttctcaacg cccattcgtc ctgctctctt cgtgagattg catattcctt 2100601 ggcagctgta tttccgtgaa cagccatgtg cacctcgtca aatgcgcacg ttaatccgtc 2100661 atacaccatt aagtccctaa gctcgccgtc ccccatccgt gctccccagc gcccggcggg 2100721 aacggcatac ggaatattgc tcatgctttc catccccccc gcaacaagta tgtccgcatc 2100781 ctgcgcccga atcatttgat cacataaagt gacagcgcga aggccggaag cacagacttt 2100841 attcagtgtt tctgacggca cactccaagg cattcccgcc agacgggcag cttgacggga 2100901 aggtatctgc cctgagccgg cctggacaac catgcccatg acgtttcctt ctacatcatc 2100961 tccagagact ccagcctgtt gcagcgcctc cttcatcaca atgcccccaa gctcagcagc 2101021 tttcacctct ttcaaaactc cgccgaattt gccaaatgga gttcttgcag cacttacaat 2101081 gactgttttc ctcatggttt cacctcattc agaagataga cagcgcttac aatttctagt 2101141 tgtcttctat gaatgtatgc tttgaaacgg gcatgaatga atgaaaaaag aaggctgcgt 2101201 caaacagcct ccttctaaca actattcatt tttcagcaat gccgaagcct tttctggaaa 2101261 gtcggtaaac atgccgtctg ctcccgcttc aatgagacgc ttcatatctt ccggacgatt 2101321 gactgtatac ggccttacct taatcaaacc gttcctcatt ttcttcagta cttcatctgt 2101381 gacccctggg ctgtttatct tcgggtgata gccggaagcc ggaatagacg cgatatatcg 2101441 atctgcctga taaagcacat ctgaagttaa tactgcccgt tcgatatgcg gtgcaagccg 2101501 ggcgcacagc gccaagctgt catgattaaa cgtggatagg atgactctgt cctctacatt 2101561 aaatcgcttc actgcctcca gcactttttc ttccattccc tcatagcgga tcacgctgtt 2101621 ttttaattca atgttgatga gaaaatcctt ttttaccgcc cacgagagca catcttctag 2101681 cagcggcact tttatatcgc tgtacgcttg atcgtgacca gcggccgcat tcgcagtctt 2101741 tacctcatca taggctgtat ccttcacgaa tcctttaagt gatgtcgtgc gattaagtct 2101801 ttcatcatga attacaacaa tgcgtccgtc tttcgtcagc tgtacatcaa gctctatccc 2101861 atccgctccg gcttcaattc ctttttcaaa tgcaagcatt gtattttcgg gaaattgacc 2101921 tgatgccccc cggtgggcaa aaatctttgt catcgtttca cctcaaaccc taaagttttc 2101981 tccattatac ttattttgtc ggctccactc taggattaag gctgtatcaa tctactgatc 2102041 ataataagaa tcaatgccat tgacaatcgc atctgcggcc ttttgctggt attcttcact 2102101 tcccagcttg tccgcgtcag agctgttcgt gataaaccca agctccgcca acacacttgg 2102161 catttgtgaa tatgtaatga cgtaaaagtc tgattctttc acgcccctgt ctctcgtttg 2102221 taaggaagaa acgagctgtg actgaatatc ggatgccaga cgccggctgt tctccccttc 2102281 ataatcagat tgaaaatacg tttctgttcc tgaagctgaa gcaacccctg aattcacatg 2102341 aatgctgaca aaaaggtcag cctgattggc acttgcctta gccactcttt cctccaaggt 2102401 cagaaaatga tcgtcagacc gggatgcaac aggattggct ccctcctctt ttagtttgtc 2102461 tgtcacatgc tctgagacag ccaaattaat atccttttca aagagcccgt ttccgaccgc 2102521 tccactgtct tcaccgccgt gtccggcatc aatatacact gttttccctt ctatcggctc 2102581 tgctgcctgt gcacaaggcg cgagcgtcaa agccaatccg cacagcgcca agctcctcca 2102641 taacattctc aacttactcc ctccggtcac gagttctttc gcagctgaat atcttccagc 2102701 tgtaaagttc cattatcctt ctttgtatat ttcaccagga catgtgtctg atctggcagt 2102761 gattcacatt catcacgttt atccttcgga acttgtatca tggtttcttc tccattaaga 2102821 gaaaccgcaa tcgtatgagg atcagccgag ccaatgtatt ttccctcttc ggtaaacctc 2102881 ggcactgagt catccgcact tgcaacactg caccccgaaa gaaagagcgc agtaaacagc 2102941 aaaagaaccg tttgtttcac atgaccacct cttcctgatg tttggctttt atctttgacc 2103001 agaatggaga atttgtaaag acaacgcgaa tgcaggcgag caagttccat gattttcaaa 2103061 agggctatac gacccgatca tttcctgttg ttagaaagat aacgagcaga tttgtctatg 2103121 aggatggctc taattgaggc gccaattaga aaaaattagc ggaaagaagc aactttttat 2103181 tcattttaaa aaatttgaga atagggtgag caaatcgttt gacgggtggg tcagccaagc 2103241 gtaacctttt aaaggatatt tactttattg aaagaagtta aagccatgaa aaaattcgtt 2103301 ctgctgctgg cggcagctgt catcacatgc tccatcggcc accaaatcag tggcggctac 2103361 aaaggccccg aaaaagagcg gccaaaacat cactctgcac tcaagatatt cagtcggtaa 2103421 agcagatcaa ttgcattaat ttttacatat aggctagaat atgtgcgaat ccaaacgaaa 2103481 gaagatgatc aaatgaatcc taagtataag ccactttttg aaccatttac gtttaaaagc 2103541 ggcgttacaa tcaacaaccg gatcgcagta gcaccgatga ctcattacgc ttctaatgaa 2103601 gacggtacaa tatctgaagc ggagctcgac tacatcatcc cccgttcaaa agagatggga 2103661 atggtgatta cagcctgcgc aaatgttaca ccggacggaa aagcattccc cgggcagccg 2103721 gccatccatg acgattccaa cattccaggt ttaaaaaagt tagcacaagc cattcaggca 2103781 caaggcgcta aagctgttgt acaaattcat cacggcggta ttgagtgccc gtctgagctc 2103841 gttcctcaac aggatgttgt ggggccaagt gacgtgtttg ataacggcaa acaaattgct 2103901 cgcgcattaa cagaagaaga agtggaaaac attgtgaagg cgtttggaga agcgacaaga 2103961 cgcgccattg aagccggctt tgacggtgtc gaaattcacg gtgcaaacgg ctacttaatt 2104021 cagcagtttt attctccgaa aaccaaccag cgcacggatc gctggggagg aagcgatgaa 2104081 aaacgattag ccttcccgct cgctattgtc gatgaagtga aaaaagccgc ttcagaacat 2104141 gcgaagggtg cattcttagt cggctaccgc ctgtctccgg aagaacctga gacaccggga 2104201 ttgacaatga ctgaaactta tacgcttgtt gatgctttag gggataaaga attggattat 2104261 cttcatatct cactgatgga cgtgaactca aaagcgcgcc gcggtgcaga tccgactcgc 2104321 acacgcatgg acttattgaa tgaacgtgtc ggaaacaaag tgccgctgat cgccgtcggt 2104381 tccatccatt ccgctgatga cgcgcttgcc gtcatcgaaa acggtattcc actggtcgct 2104441 atgggacgcg aaattctagt tgaccctaac tggacggtaa aagtaaaaga aggccgtgaa 2104501 aagcaaatcg aaacagtgat caaaggcaca gataaagaaa aatatcattt gcctgaaccg 2104561 ctatggcaag caattgtgaa cacacaaggc tgggtgcctt ataaagatta atgtgcaaag 2104621 actgccgaaa cgattcggca gtcttttttc cctttatata aatagtttgt gtacacatct 2104681 aaacagcaaa agaaagagct ccccaccaac ttcgaaaaga aaatccagga aaaacccctc 2104741 acgctttctt gcttttttct ttttcattcg tacgtctcct ttttacatga atacgcctta 2104801 cttacgattt tgcaggagaa aggtttcatt ttataacgga cacatctagg gtcgatcatg 2104861 cttcgtgatc ctataagatg tatgaatgga ccaagagtgc aggtaatacc gccatttgct 2104921 ttccttactt ttcaaaccta tcctttacta tatgcggata cttaatattc ttctcccata 2104981 ctacaaatgt ccccaaaaca aaacgcctcc tatttatcag cgcaaactaa taaataaaag 2105041 acgtttgatt taatgaccac ttaataagct catgtttaag aagccttatg ctctaacctc 2105101 agcttatccg caaccattgc aatgaattca ctgttggtag gtttagcttt tgtcatgctg 2105161 acagtataac caaacaacga ggaaatggaa tcaatgtttc ctctgctcca tgccacttca 2105221 attgcatggc ggatcgctct ttctacacgg cttgcggttg tgttaaattt tttggcgatg 2105281 tccggataga ggacttttgt aatgctgccg agcaattcga tgtcattgta taccattgag 2105341 attgcttcgc gcagatagag atagccttta atatgggctg ggacgccgat ttcatggata 2105401 atgcttgtga tgctcgcgtc gagatttttc ttctttggtt caggctggct gctgcgtata 2105461 atactgcttt gcgatgatgg cgcacgatgc gtcacactgc tggcatttcc gctgacctgg 2105521 cggatatggc cgacaaggtt ttccatatca aacggtttga gaataaagta ggacgcgcct 2105581 aaatcgacgg cctttttcgt gacatcttcc tgcccaaagg ctgtcagcat aatgacattc 2105641 ggctgttttt tcagatctga ttccctcagc ctctctaaaa ccgcaagtcc gtctagatgc 2105701 ggcataataa tatctaatac gagcacatcg ggatcttttt ctttaaacag cgacaggcat 2105761 tcctgtccgt tataagcaac gccgatcact tccatgtctt cctgtccttc tatatattca 2105821 cttaacaggc ttaccagctc tcgattatca tcagcaacac aaactttaat tttctccacg 2105881 tttcttcctc cccaaatgta gttaacagga ttcacccttg ctacatgttt acattcgaca 2105941 aaaccgctat ataccctcta aaaaaatcat aatcaccaat attagtggca tatctttgtt 2106001 attctatgtt tttctctgtt tttcgactaa aaatgaaatt tgacaaacaa ggaaacgtga 2106061 atttgtcgaa aaatcttctt ttgtatattt taccgtatgt attctgagaa gtgaagaggg 2106121 atcaaaataa aaaaactgcc ggaaactccg gcagtcagct tgctttttct tttccataaa 2106181 tatcgattcc tgcttctgac agcatccatt caatatgaac accgtagccg cttgtcgggt 2106241 catttacaaa tacatgggtg acagcaccga tcacttttcc attttgaatg atcgggcttc 2106301 cgctcatccc ctgtacgatg cctcctgttt ctttcaacag tcttggatcg gtaattttca 2106361 acaccattcc ttttgtcgca gggaattttt gcggcgttgt gctgacgatt tcaatatcga 2106421 atttttctac tttgtcatca tcaataaccg ttaaaatttc agccggccct tttttgactt 2106481 cggtagaaaa cgcaaccggc aatgcttgat ctgatatgtt gttttgaatc ggctgatgca 2106541 gtgtgccgaa aatcccaaac gggctgtttc tgttaatatc cccgatcgtt ttgcgttctg 2106601 aggaaaatcg cgccagtttt tctcccggat taccgcctgt ccctttttca attgatgtta 2106661 cagtggattt aacgatttct ccattctcca ctacaattgg tttctttgtg tccatatcgg 2106721 aaatcacgtg gccaagtgct ccgtattttt ttgttttcgg ttcataaaag gtcatagtgc 2106781 cgatgccagc agcagaatct ctgatatata acccgattct gtatttgcct tctccttcat 2106841 ccttttctgg gatcagcttc gttttgattt tctgtttatc acgtttgatc agtaagtcta 2106901 aagattcacc agttttccca gccttttgaa taaatggggc tacatcattc attttttcaa 2106961 ttttctgtcc attcatctca ataatgatgt cgcccgcttc aattcctgcc gtttctcccg 2107021 gagatttttt gccttcactt gtattgattt gatgaaatcc gacgacaaga acaccgacgg 2107081 aatgaagttt tacaccgatt gattgtccgc caggtataac ttttaaatca ggaagaacat 2107141 gcacttttgt ttttttaatt ggaaatccgg caagatcata taccaattct gactcacctg 2107201 attttttgcc cgtcaccttg atttcatgcg gatctttctt tactgtaaac gcttctgagg 2107261 attctgatgt ctgagcgttt accgataaac tcgtttcaat cgcttgtgtt tgggtttcaa 2107321 atactctcat ttgcgttgga atcagtaaat attcttttag cggtttgcat aaacctacac 2107381 ttaataacga aacaaggaga attaaaccta ctgcttttct gatgttatcg ggcattcact 2107441 acttcactct cctcgctcct atcccacacc ttctttatga cttgctgcta catcatttaa 2107501 ttttgccttc tgacggctta tttataactg tcatatgaag aaaaacattg gatatactga 2107561 tgaacgaatg gatgtgcacg aaaaaaataa gctgcgcttc tcgcgcagct tacccagttg 2107621 ttttgacttg atccgcttgt tttaaaagtt ctttcgcatg gcgtttcgtt aagtcggtta 2107681 cttcgacacc tgcaatcatg cgcccgattt ccgctacctt ttcctgctta gagagcggct 2107741 tgacacgtgt cgtcgttctg ccgtctttta actccttcgc aatataaaga tgcgtatcgg 2107801 ccatggcagc cacctgaggc aggtgtgtaa tgcacagcac ttgtgatcct attgacacct 2107861 tatggatctt ctcagcaatt gcctgtgcga ccctgccgct tacaccggta tcaacctcgt 2107921 caaaaatgat cgatgtcaca tcctgttgtg aggaaaaaat gctttttatg gcaagcatca 2107981 cccgtgacag ctctccacct gaagcgactt tcgaaaggga tttcagcggc tcgcctgtat 2108041 tggttgaaat taaaaacttc accaggtcaa tcccttgttc agtcagctga acgggctggc 2108101 cgtttacaag cggcgcctct tcattgcgtg acgctgttct gaccttaaat tccgtatcaa 2108161 aagttgattt ttccatgtac aggcttttta attcccgatg aatctcatca gccagctttt 2108221 tcgcccatgt ttttcggatt tgtgacacat ttgccgcttc cactgcgaca tctttgccga 2108281 cggagtcaag ctcctttttc aagctttgaa ggtggctgtc cctgttttca atttggtcaa 2108341 tctcttcttc aattttagaa gcatattcca aaatgtcttc aacagtggca ccgtattttc 2108401 gtttcagctg tttgatttca ttaagtcgcg tctcaatata gttcaggcgt tccggatcaa 2108461 attcaagctc atccagcata tttctcatct gaaatgtggc atcctcaagc aaatagtagg 2108521 agttcgaaac actttcagac atttttttca gcggttcgtt tatatcagat atatcttcaa 2108581 gctgcgctga tgccattcca acccagtcca atccgccctg ctcactgcga agcgcgttat 2108641 atgcattttg cagcgactca tatatcttct caaagtttga aatttgctgg cgctcttctt 2108701 ggagctgttc atcttcgtta agctcaagct ttgccgattc gatttcttcg agctgaaatt 2108761 gaataagatc aagacgatgg gccatttcct gttcgctttc agaaagctgc ttaagctttt 2108821 tgagcagctt cacataccgc tggtaccctt cctgatacgt tttgagcgcg ctttccactt 2108881 cggccccggc aaacttgtcc aaaagctgga gatgattttc gtcttccatt aacagctggt 2108941 tatcgtgctg cccgtgaata tctaataaaa gcctgccgat ctctcttagt gaagcaatcg 2109001 tgacaagctt gccattgaca cggcaaacgc ttttcccgct cgtgctgata tcccttctca 2109061 tgacgatcat ttcgtctgaa acgtcgattc cctgctcagc gcatacgcct aaaacaggat 2109121 ggccgctctc caacagaaac agcccttcaa gttcggcttt tgcttcccca tatctaacaa 2109181 attcagatga tccgcggcct ccgactaaaa gagaaatggc atctatgatg atggatttgc 2109241 cggctccggt ttctcctgtt aaaaccgtaa gcccgcgttc aaaagaaacc gtcagttcct 2109301 caataatggc aaagttttta atcgatagtt cagctaacaa acagcattac acctcttatc 2109361 tttgttagat tttctgttac agcagttcaa ggagcctgtt ttttacgcct tctgtatctt 2109421 caggagtccg gcaaataatt aaaatcgtat catctccgca aatggtcccc atcatttcat 2109481 cccagtccaa attgtccatc agcgccccga ttgcctgggc attgcccggc atcgttttca 2109541 gcacaatcat atggcttgct gagtctattt tcacaaatgc gtccatcaat gcccgcttta 2109601 gctttgacag cggattgaaa cgctggtccg ccggaagact gtatttgtaa gaaccattat 2109661 ttgtaggcac ttttacaagg tgaagttctt taatatcccg tgataccgtg gcctgcgtta 2109721 ctttgtatcc atcctgcttt agcatgtcga ccaattcatc ctgcgtttcg atttcattgc 2109781 ttgtaatgat ctctctgatt ttaatatgcc tctggccttt gttcatgtaa gcacctctat 2109841 ttccaagctt atctgttctt ttatgttata tgattctctg cacattgtac atgaatgcag 2109901 aaaaaaggaa taatagcgcc ctattattcc ggtacatctg cttttttttc ttttaacgtc 2109961 ttatgtgctt cttctacaac gcgcatgatc tcttcttccg gcagttcctg gccttcctgt 2110021 ccctctcccg gccaatgcaa atgaaggaga aactcaatat ttccgtctcc tcccgtgatt 2110081 ggagaaaatg acaagccttt acagatatag ccttcagcgg cagaaaaact gatcattcgc 2110141 ttgagcacat cagcatgcac tttaggatct ctaacaatcc cttttttgcc gacggattcc 2110201 cgtcccgctt caaactgagg cttaactaaa gccatgcagt cgctgcccgg tacgagcaaa 2110261 gtccttagga caggcaggat gagccgcagt gaaataaagg acacatcaat tgtggcaaac 2110321 tccggcatgc cctttgtaaa gtctgccggt gttgcataac gaaagttcgt ccgttccatc 2110381 acgacgaccc gttcatcctg tctaagcttc catgcaagct gattatagcc tacatccaca 2110441 gcgtatgact gtttagctcc attttgcaaa gcgcagtccg taaaaccgcc ggtggaggag 2110501 ccaatatcaa tcataatttt atctttgaca gagacgggaa attccttcaa cgctttttcg 2110561 agctttaagc cgcccctgct cacatacctc agcgggtttc ctttgacagt taacggaagg 2110621 tcgcggtcaa ttttttctcc aggcttgtcc aagcggtttt cgtttgaata gacgatcccc 2110681 gccataatgg ctcttttggc tttttcacgc gtttccgcca gccctctttc cactaataat 2110741 acatctaatc gttctttctt tgacgtcatg atccaattcc tttgtgtgtc tttggtggca 2110801 tcagtaatct aatacgattt gccacctgct gttttgtcag tccaatttcc tcaagaagcg 2110861 ctgttacact tccgtgttca ataaaccgat caggtatacc cattctgtca atcggagtat 2110921 gatattcacc ttgatcatga gcgaattcta aaatcgagct tccgaaaccg ccttctaaga 2110981 ccgcttcttc aattgttaaa attggcaagc cttcttttag gatactcttc atcatctttt 2111041 catcaatcgg cttaataaaa cgcgcattca caacgcgcac ggaaaggcct tctttctgca 2111101 gctcttcggc tgcttcaatc gccatttcga ttgttgtgcc gaatgttaag atgacagcat 2111161 cgttccctgg acgcagcacc tcccacgtac cgatcggaat cgttttcaac tgttcatcca 2111221 tttttacgcc gagtccgttt ccgcgcggaa aacgcattgc tatcgggcct tcgtcatagc 2111281 taagtgctgt atgaaccatg tgctggcctt cattttcgtc tttcggcatc attaagacca 2111341 tgtttggaat gtggcgcata aacgcaatat caaacacgcc ttgatgtgtc tctccatcag 2111401 cgccaacgag tccagcacgg tcaattccaa taaacacatt agcgttttgg cggcagatgt 2111461 catgaacaac ttggtcatat gccctttgca ggaaggttga gtaaatcgcc aaaaacggct 2111521 tcataccctg cattgccata gctgcagcca ttgttgcggc atgctgttct gcgattccta 2111581 cgtcgaacat ccggtcaggg aattcctttg cgaagccttc aagctttgaa ccgacaggca 2111641 tagccggcgt aatggctaca atgcgtccgt cctcgcgcgc cattcgctgc acagttccgc 2111701 tgacaagacc gctccacgaa ggagctgcgg ctttcggctt tacaaagtca ccggtattaa 2111761 ttttatatgg tccggtacca tgccatgtcc caatcgtatc ggtctcagcc ggtttgtacc 2111821 ccttcccttt tttcgtaatg acgtgcagaa gaacagggcc tttcgttttt ttggcgtatt 2111881 gaagattctc aatcagctca tgataagaat gtccgtccac tgggcccaaa tacgtaaaac 2111941 cgagctcctc gaaaaacatt ccggagacga gcatgtattt caggctgtct ttgacccgtt 2112001 ccgccgtggc ggcaagcttg cccccaactg ccggaatctt tttaaataag tattcaagct 2112061 catctttgac ccactggtat ttccccgcag tgcggagccg tccgagcata gagtgaatgg 2112121 caccgacgtt tggcgcaata ctcatttcat tatcattaag gatgacaatc atgtcttttt 2112181 tctcgtcgcc gatgtggtta agggcttcga gcgccatacc gccggtcagc gcgccgtcac 2112241 caatgatcgg aataatatat tcatccgttc ctttaatatc acgggcagct gccattccca 2112301 tcgcgcctga cagagaagtc gagctgtgcc cggtttccca aacatcgtgc tcgctttcac 2112361 tccgctttgg aaatccgcaa agccctttgt actggcgaag cgtcgcaaat tcttttccgc 2112421 gtcctgtcag cagcttatgg acatacgact gatggcctac atcccataaa aatttgtctt 2112481 tcgggctgtt aaattcctta tgcagggcaa cagtaagctc tacgacacct aagtttgggc 2112541 cgatgtggcc gccggaagcg gataaacttg taattaaaaa ctgacggatt tcatcactta 2112601 atttctctaa ttcatcaatg gacatgtttt ttaaaaacga cgggtcctgt attgataaaa 2112661 gatccaaagc ggatcaactc actttcagca tgaatttctg caatgataca tgtcttttgc 2112721 atgccgagct gacaataatc tcagacataa aaaaagacaa acgcgctttt ccttttcatt 2112781 tttcatataa actgcttaca ttttaccata cctcgtgcag ccgcttcaaa ttaggatcgt 2112841 tttagtgatc tcttgccgca attaaatcac aaagctcata taaaaggtct ttttgaagag 2112901 agagtccgcc gatcaatcgc ttcgcctctt ttatatgaac atccaattta tgtttggccc 2112961 cttccaatga aagaagcgac gggtatgtcg atttgtcatt tgtggtatcc gagccgacac 2113021 gtttgccgat tttctcttca ctgccttcta aatctaaaat atcgtctctg atttgaaatc 2113081 cgattccaat gtggctgctg aaggtacgca gtgtttcaat gtcttcctca ggcgcatcag 2113141 ccaaaatagc accggcgatt acacaaaagc caaggagctt ggcagttttc cgttcatgaa 2113201 tggattcgag ctcttcaagc gtgacttgtc ggttttccgc ttccatatca gctacttgcc 2113261 caccgaccat gccttcggtg cctgccgctg aaatcagttc attcacaagc cgcaggcgct 2113321 tttctgctga cacctcgtct gacacgtggg aggtaatcag cttaaagctt tctgtgagca 2113381 gcccgtcacc cgctaatact gccgtcgctt caccaaacac tttatggttt gtcggcttcc 2113441 cgcggcgcaa atcgtcatca tccatgcatg gaagatcatc atgaattaac gaatacgtgt 2113501 gaatcatttc gacagcacag cccaccggaa tgccgtcttt ttcgcttttt ccatatgcat 2113561 ttaaaacagc cagtacaatc agaggccgca accgctttcc gccggcctgt agagaatata 2113621 gcatagattt ctttaatgag tccggcatat caagcttttc tgtatagaca gaaagctgat 2113681 tttcaattgt ttttttccgg tccgccagaa agctcgttaa tttatttgtc accttcgtct 2113741 tcctcctgaa cactgaaagg tgccagttcg ccgtcttctt ttaaaatgaa gtccatttgc 2113801 ttttcgactt tttgcagctt ttcatggcac atttttgaca gagccatgcc ttcttggaaa 2113861 tagttaatgg cttgctctag aggcacatct ccctcttcaa gctttgatac aatgctctca 2113921 agccctttca tcgcttcttc aaatgtcatg ttttcatttt ttttcacgtc tgtcattttt 2113981 cttcccctct cttttctaat acttcacagg tcagcacgcc atccttcagc ttgatttcaa 2114041 gccggtcctg ctcttctatt tgactgacac ttttaatgag tttatcttct ttataagcca 2114101 agctgtatcc tctttccatc acttgaagag gacttagtgc attcagcttg ccaagaacgg 2114161 tttgaaattg ggaatgcagc tgcttcattt ggatattcat attttttctc agctgatttg 2114221 tttgttcctg gtatcgtgtt ctcgcttgtt tcagctgttc atgaggatgc aatgcctcta 2114281 atctgtacgt ttcacgctcc agctgtctgc ttttccgatc taaaagagcg gtcagctgtg 2114341 cttgaaactg ctggtacgcg aggtcaaact gctgctcttt ttgcgcatac aaacgctttg 2114401 gaaaacgaaa ggcataggac gattgcagcg tttgtatccg ttcttttttc tggccgagat 2114461 gctgctgcat tgctcttgtc attctgactt ccgctgtttt tgtccgttcg attaaatcag 2114521 tggtatgagg cacagcaatc tcagctgctc ctgtcggcgt cgcagctctg atatcggcga 2114581 caaaatcact aatcgtaaaa tccgtctcat gtccgactgc cgatataatc ggaatattgg 2114641 aagcaaagat ggcgcgtgct acaatttctt cattgaatgc ccacagttct tctatcgaac 2114701 cgccgcctct cccgacaatt aatacgtcgc aaatctcttt ttcatttgcc tcttcaatgc 2114761 gcgtaacgat ggatctgctc gcattttcac cttgtacgag cgctggaaga acaatgactt 2114821 ttacaagggg atatcttctt tttagagttg taataacgtc tctgacagcg gcacccgttg 2114881 gagatgtcac aaccccgatt gtggctggaa atgcggggat ttgttttttg tagcggtcgt 2114941 caaataaacc ttctccggca agcttctttt ttaattcttc gtacgctaaa taaagcgctc 2115001 caaccccgtc aggctgcatt tctttggcat ataattgata gtttccgctc ggttcatata 2115061 cggaaattcc gcctctgacc agcactttca ttccgttttc aggtttaaaa ggcagacgct 2115121 cgctttgtct cgcgaacatc accgactgca ttcttgcgtt ttcgtctttt aaagtgaaat 2115181 aaatatgccc tcgtgtgtgt atctttacat tcgacaattc gcctttaatc caaatatttt 2115241 caaggtgagg atctacatcg aattttcgtt ttatatactt tgtcagcgct gagacggtca 2115301 catacgctgc ttcacccatg tctaaaaact cctctcctaa gcattcctgc accataacta 2115361 aagaaaaccc gccctggctt taggagcctg aagaagcggg tatcgtgctc atattcaagg 2115421 cgggtaaaca tttcgcctgt gaatatctcc aattatctat gataacgtac gtttcgcaga 2115481 tttaacagta ttatgcgcaa gcatcgtgat ggtcatcgga cctactccgc ccggaaccgg 2115541 cgttatgaag gacgcttttt cctttgcccc ttcaaattca acgtctccgc aaagctttcc 2115601 gttttccaga cggttaacgc cgacgtcaat gacaacagcg ccctctttga tctggtctgc 2115661 actgatgaag ttggctctgc cgactgccac caccaggatg tccgcttttt tcgtatgttc 2115721 agtaatattt tctgttcttg aatgacagta agtaaccgtc gcgttttcat ttaataaaag 2115781 ctggccgaca ggtttgccga caatgttgct tcggccgact acaacaacct ctttaccgga 2115841 aaggtcaata ttggttttct tcaaaagctc aacaattcca tgaggcgtgc aaggaagaaa 2115901 cgtatcttcg ccaagcagca ttttccctac gtttaacgga tgaaaaccgt ctacatcttt 2115961 atcaggggag atacgttcga tcaccgcttt ttcagaaata tggtctggga gcggaagctg 2116021 aacgagaatg ccatgaaact cagggtcttg gttatattga tcaataatgg aaagcagttc 2116081 agcttctgtg aggctgctgt caaattgatc gagcttgaaa ttcattccca ttgtttctgc 2116141 cgcttttttc tttcctcgca cgtaagagtg agaagcagga tcatctccaa tcaaaataac 2116201 cgccagtccg ggagtgacgc cttgcttttt aagctcttct acctcttttg ccaattgttc 2116261 gcgtttttct ctagccgttt cttttccgtc gatgattgtt gcagtcattt tctttcctcc 2116321 tatgattgtt caatatcaga tttaatgtta gaaagaaccc cgtttacaaa ctttgtcgct 2116381 ttgtcatcac caaaccgttt tgccagctca atcgcttcgt tcatggagac attcaccgga 2116441 atgtcttcgg catatgccat ttcatatgct gccaggcgca aaatcgcacg gtcaacattg 2116501 gcaatccgat cgagcttcca attcaccaga tgcttggaga tcatttcatc cagctggtct 2116561 tggtgttcca ataccccgtg tacaagctgt tcaaagaaag gatctgtttt ttcttcatcc 2116621 agtgcgtgtt ctatggcttc attcactgca atatcgctga catcaatttg aaatagtgcc 2116681 tgcaaagctt tttctcttgc tgttcttctt ttcattttct ttctcctttg atcctcttta 2116741 tccgcttgtc gttaagccac aaagagatca taacatattt ttttcgtatc cgcatattga 2116801 aatcaaggtt tttttaccct attaccgaat attttcacac accttaatat gattattcgg 2116861 atttcacgtt catgaagaaa ctcggctatg taagccggct ttcttcatgc tttgaaataa 2116921 agggtaacgt gtaaaaaaac caaagggccg ccctcccctt ggtttcgtgt taagccattt 2116981 acatttcttc gtcgatttgg acttcttggg cttttgtgtc aaattgaatg ccgacgatgt 2117041 gaatattgat ctcgttaatc gaaagagacg tcatatttaa taaggtttga cgaatgtttt 2117101 cctgaacgga tgctgcaact ttcggaatcg aaacgccaaa tgtaacgaca cagtatacat 2117161 cgatcgtaat tccgtcatcc gccaggtcga ctttgacacc tttgccatga ttcactttgc 2117221 caaagcgctc aacgacgcct gtcgcaaagt ttccgcgcat ttcggcaact ccatcaactt 2117281 ctgatgctgc aatgccggca atgacctcaa tgacctccgg tgcaatctca accttaccca 2117341 aatgcgtatc ttcgtgatcc attttaagca agctgttgtc tttcattcaa ttcacctccg 2117401 taaaaattat gagcccatta catcatatgt ttctaaaaat ttcgtattaa actctccgct 2117461 cacaaatgtt tcgtgttcaa gcagttttaa atggaaaggg attgttgtct caatgccttc 2117521 gatgacgaat tcgctcaatg cgcgcttcat gcgggcaatc gcttcatctc tcgtttttcc 2117581 gtatgtgatt acctttgcaa tcatgctgtc atagtacggt gggatggaat agccagggta 2117641 cgcagctgaa tcgacacgga caccaagacc gccaggaggc aggtacattt taatttcacc 2117701 aggtgacggc atgaaatttt tgcttgggtt ttctgcgttg attcggcatt cgatggccca 2117761 gccttcaaat tcaacatctt cttgcttgag gctcagttcc attcctgaag ccactttgat 2117821 ttgttccttg atcaggtcag ttcccgtcac catttctgtg actgggtgct ccacctggat 2117881 tctcgtgttc atttccatga agtaatagcg ctgttcattg tagtcataga taaattcaac 2117941 tgttccagca cctgtatagc caaccgcttt ggcagccttt accgctgcat ctcccatttg 2118001 ctccctgatt tctgaatcaa gggcaggaga tggtgattct tccaaaagct tttgcaggcg 2118061 tctttggatc gagcagtcgc gttcgcccaa atggatcgta tttccgtagt tatcagcaag 2118121 cacttggatc tcaacgtggc gaaaatcttc tatgtatttt tcgatgtata cacctggatt 2118181 cccaaatgca gttgccgctt cctgctgtgt aatcttaatg ccattaatca gttcctcttc 2118241 agtgcgggca accctaattc cttttccgcc tccgcctgcg gtggctttta taattacagg 2118301 atacccaatt tcattagcaa gcgaaaccgc ttcttccaca ttttctataa ttccctgtga 2118361 acccggtacg attggcacgc cggcctgttt catcgtttcc cgcgcaacgt cttttgttcc 2118421 catttttgaa atggcgtcag cgctcgggcc gacaaacgtg acattcactt cttcacataa 2118481 ttcagcgaaa tcagcatttt cagctaaaaa tccgtatccc ggatgaatgg cgtccgtgcc 2118541 agtcagcttt gcaacactca caatatttgt aacgtttaaa tagctgtctt ttgatgcttt 2118601 cggtccgata caaaaagctt catcggccat ttgaacatga agggcatctt tatcagcttc 2118661 tgaataaaca gcgacagtct caattccgag ctctctgcag gctctgatga ttctgacagc 2118721 aatttctcct ctgttggcga tcaatagctt tttaatcatg ttcagtctcc ttactccgct 2118781 tttacaagaa atagaggttg tccgtattcg accagctggc cgttttctac taatacttca 2118841 acgatttcgc ctttcacttc tgcttcgatt tcgttgaaaa gcttcatcgc ttctacaatg 2118901 cagacaactg tgttttcatt tacttttgaa ccggctgtta catacgggcc agcttccggt 2118961 gatgaagaag cataaaatgt tcctaccatt ggtgaagtga ttttatgcag attctcatct 2119021 tgctttggtg cttcttgggc aggtgccgct gcttgctgcg cttgcggctg aactgcctgc 2119081 ggagcctgtg cttgtacagg tgctgccggt gcctgctgca tgacttgaac cgtgcctgct 2119141 tcgtgttttt tcagttttaa ggatacacct tcattttcat atacgaattc gtcaattgta 2119201 gactcgtcaa ttgctttaat cagctcgtgg atttctttga tatttaacat tcaatcgcac 2119261 tcctatgtat gaaatttctt tttttatagg ttactactaa aagtacatac tatgttcatc 2119321 ttacaggagc ggacttttga attcaactct aatatgacag caacgcaaaa agcccgcttg 2119381 tttagcgggc ttttttccct cattcttatt tagagggttc aaatgtgaca gcgacatctt 2119441 tcattgtttt gatttctttt gccacaaggt ctataatggc tgtcgccttc gatttagagt 2119501 gtttgtctga tttgactgta atattgattt tatctccttc agcattaaca agcgcatcct 2119561 cgtaaccttg tgttttaatc agcgtttcca gctgtttttc tgttccttcc acttcactga 2119621 gagccgtcat tttatcgtat gcttcgcttt tctccttggc tgttgcatca tcgcttgaca 2119681 caatggcatt cagctcttct ctttctttgc ttctggcatc ttctaaatca agacggtacg 2119741 ttgtaaacaa atcatcatcg gctgtttccg taacaacagt tcctttttca ctggcttcag 2119801 cggatgtttc cttgtctgct gatgaatctt tcgttccctt tgttccatct tcttttcctt 2119861 tttcagtttc tgtaccgctt ttttccttcg tgtcttgctt ggcaggcgct ttttcagttg 2119921 cgacctctcc gctgtcagac gcgctttttt cactttgcat ctgcacggcg tttttgcttt 2119981 ccggcgacat gatatagtag acgcttaaca ccacgacaag actgagcatt gttaatagcc 2120041 aaacggtttg ttttttaagc atttatgaat cctcctttat ttttttaggg gcaaccgcaa 2120101 cccggtggct tggaacatcc aggacccgtg tcaccgcttc gataatggtt tgttttattt 2120161 gaacgttgtc cactccttga gcaacaacga gtacaccgcg tatatcaggt tttttcgttt 2120221 ggacgacgac aggtgtttct ttatcgccgt ttttgatcat gacgatttct tcctccgatg 2120281 attggtctgt aacgcttctt tttccgcctt ctttgtcagt ttcttcagtg gttgtatttt 2120341 tgtttgattt gtttttttcg tatactttca gcgacgttgc atctacattc acgacaaccg 2120401 agacatcgtc cacaccaatg attgtttcaa gaatttcttt cagttgattt tcgtattctt 2120461 tttcatagtc atcgatcgag tctttaggtt tatcagattt tgaggcttta aacacttcgg 2120521 ctgttttctc tttgctgtct gcggaatgtt gtgatgatac ggccgttatc gttttggcgt 2120581 tttcagtttt ctcaggtgaa gaaaacagct ggctgacaag cataaaggaa actccgagaa 2120641 caaaaacgaa tagaaagtaa tgatatttgg tcagcttcgg cttttcgccg tccttcgttt 2120701 gtcccggaag aaactgcttt ttcaatacat tccataatcc gtttttattc attgccgaca 2120761 ctctccccgc cttccatatg aaccgtaatt ttctcacttc cgatttccca aatgtccgcg 2120821 agctgcgttt gtatctgttt ggcttctttt tgttcggctg cttcttttgt tacgtatgca 2120881 tgatctgtat caatgtggac cggcgcgacc gtttggaccg ttttttcaga agacggggcc 2120941 atatacacgc tgattgtttt aatatcctct tctgaatcta ccttttctcc tgccgtgagt 2121001 ttgatgcggc ctactttata ttcatcatga ctgaatctct cctccgcttt cttttttagt 2121061 tggacagcca tttcttctag aatatatgcg cgctgggaag cttgtatttc tatttttttt 2121121 gaattgattt gattttttat gtcggcagac tctgactgcc cgttttttgt gaggtattca 2121181 aagatgactt cggggtctgt cttgaaaagt ttaaaaatcg gcgtaagcat gacgacaatc 2121241 aagagcaggc tgactaccat ttttgcgtac ttttgcatgc tggagctcgg cagcagcata 2121301 tcaatcacaa ttgcaaatag gataaacaac acgatggtgg taagccattc cgttaaaaaa 2121361 ctcatttgcc tgcctccttc atttcatcat catcgtgagg tttccggctg tgattatgac 2121421 agtaaggctt aaaaaaaaca tgagagacac aatggcgaga gctgcaaaaa tataaatgac 2121481 gcttttgctg atgacgtcga ggcaggtgat gacgggcccg cctcctagcg gctgaagaat 2121541 cgcggctgcc agcttataaa taaaagcgag ggaaagcact ttgattgccg gaaatgccgc 2121601 aatacagatc aaaatagcga caccgagaat ccctaccgta tttttcagca gtaaagaggc 2121661 gctgattact gtatctgttg cgtctgtaaa cattcggcca agcacaggaa taaaatttcc 2121721 ggttataaat ttagccgtcc tgagcgtaat gccgtctgtc actgcagctg acgctccctg 2121781 aacagagatg acgccgagaa agatggtaag aaaaacagcc agtgctccga tggcgatatt 2121841 tctgagcagg ttagccagct gcgttacttt gtattgttca gtcatcgtgc tgacaatgct 2121901 cagaatcgct gataaaaaaa tcagcggcat gacgatattc tgaatcaaga gaccgctcgt 2121961 gttcatcagg aagaggataa caggatgaaa gaaggcagca gatacagctc cgcctgagga 2122021 agccaaaagc gccaagagga gcggaatgag cgccaggata aagctggtca tcgtctgaat 2122081 cgcctcagtt gcatagttaa ttgccacatg aaagctatta agcgcaagga taatcagcac 2122141 catgtacaca attgagtaag cgaccttact gacggtgctt tgctgaaaag cattttgcaa 2122201 aagctgcaga atgacgcaaa aaatcgtgag caaaatcaat gtgcccagca gctttccgtt 2122261 ggcaagcact tcatgaaaca aataagaaaa gagagctttc agccattctt gcggtgagaa 2122321 tgatttatcg ccattgataa actccattaa gctgcctttt tggctttccg gcagcagtcc 2122381 gccgtattct gtcataatgt cattccaaaa ttccccgatc ttatctgttt caagcgaggc 2122441 tgctgtcctt tccgctaatt gctcggctgt ttcagcatgg tcttccgttt gttctgcatt 2122501 accagctgct tgtacaattt ctgcacggcc tgctatgatc agcacggcca aaagcaaaac 2122561 ccattgaaag cgcttcaatc taccgcctcc tttcggttat gacatagaag gtataagtcc 2122621 gagaatcgtt tcgataatga cggttaaaat aggcacagcc attacgagta ttaaaatttt 2122681 ccccgccaat tctattttcg aggcgatggc tccttgaccg gcatcttttg tgagctgtgc 2122741 cccgaattca gcaatatagg cgattccgat aatctttaaa atggtttcaa catagaccat 2122801 gttgacattt gcattaatcg caattttttc tatcattcga ataatgtcgt agatttggtc 2122861 taccaaataa agaaaaatgg cacatccggc aaaaacgacg attaaaaacg caaaagtcgg 2122921 cttttgttct tttacaatta aagaaaggaa ggtggcgatc agccctaaac ctacaatttg 2122981 aacaatgtca atctgcaagc ccccctatcc ttggaataaa aacacagctt ttatcttttt 2123041 aaataggtca tctacaatcg tggcgaccat aaataaaata tagataaaac ctaacagcgt 2123101 cacccactga gcatattctt tcttgcccat ctgatccaat atcgtgtgta aaaaagcgac 2123161 cacgattccc actccggcga tttgaaatat gacattcacg tctactccca ttttattttt 2123221 gctcccctca cgtttacatc aatagaagaa tgagtaacaa gcccgctaaa aagcccaaac 2123281 tttttatcat cttttcgttt ttcgcttgcg cctgctcagc atccgcttct gaggcttcca 2123341 aatgtgtcag cgccagcttg atgtgctttt gctgagagat tcgatcatga atcccaagcg 2123401 tctcgccaaa ctgcttcagc acttcgtatt cgcttttttt caaagacagg gtgtcccata 2123461 ccttctttaa gctttgctcc cacgccgttt tcgcggaatc acttcccttg tccagctgat 2123521 cactgaatgc ggaaaaaaga gttgaaacag gctgtgcgag ctgtttggca atctgctgtg 2123581 aagcagtatg aagcggtgta tggccgtaca tgatttcagc ctcgagggat tgaagcgccg 2123641 cacgcagctg gcggatttgc cgcggccgtt ctgtataaat cttcgccatc tcaaaacctg 2123701 tccatgttgt cgctaccaca atgaatacag cgcccagcag cttcagcatg ttttcacgcc 2123761 cgtcgtccta gacagcacat ttccgtcttt gtcataaatt tggctcactg tgcccggccc 2123821 ttttgctctt gataattcca aatagcggtc aaaggctctt tcttcccaca aacgcttcaa 2123881 tgaaggccgc ttcatcaggt cggatatact ccagccatgc gccgatacga ttactgaaac 2123941 accggcatgc agcgcctcca gaagtgcatc tgtatcttcc atacgcccga tttcatcgac 2124001 aatcatcacc tcagggctca tggatcgaat catcatcatc agcccttcag cttttggaca 2124061 ggcgtctaac acgtcaattc tctgaccaaa ttgatgctgc ggaataccgc gaagacatcc 2124121 ggcaatctct gaccgttcat cgacgatccc tgtctttacg ggcagcatgt tttttttgcc 2124181 ggtgcttgag agcctcgcaa ggtcccggag aagtgttgtt ttgccggttt ggggcggtcc 2124241 gataatcagc gtattcagcc agctgttttg atataagtat ggaagcagcg gctccgcaat 2124301 ccccagcttt tgccgggcaa ttcgtatatt aaaagatgcg atgtcacgga ggcctttcac 2124361 acctccgttt tccgtaatga ctctgcccgc cagtccgact ctgtggccgc ctctgatcgt 2124421 gacataccct ttcttcagct cttcttcaag tgtatacata ctatagttgc tgagccggct 2124481 caggatcaga tgggcatcct cggccgtgcc cgcataggac aaataaacag gttgtcctct 2124541 tcgaatcaat tcaacagggc ggttgatccg aattctgact tcttcgattt ccagccattg 2124601 ttgttccggt atttcagaaa gggcgttttt catggattca gggagaacct cagcgatttc 2124661 attcaacaga gcctcctcct ttctaccgat tggcttcttt aaaatgtatg atgtgaggca 2124721 gactttatga caagcctctc tttatttatg aacacccgcc aaaatcaaga caacacccgt 2124781 aaaaatcaga atcagctttg catacgaaag ctgcccggca atttggtaga ttccgacagt 2124841 cattgtaatg ataaaaatca acggaccgac aatagcgaga atgctgttaa ccacaaccgc 2124901 cttccggaca tcgttggtca caagcatgac aattgctgcc gtcagctcaa tcatagagga 2124961 taaaactcgt aatcccgcca ttgttaaaac agtagaattg atatttccaa gtaaaaattt 2125021 catagcactc tcccaacctc ccattttttt atatgatatg ctctagcttg ctgaagtagt 2125081 cttgtcattt tcgtataaaa gaaagattct gtttttgggc acaaaaaaag cctgctccca 2125141 tttgggaaca gacttctttt tttctttcta tgctcttgaa acgtaagaac cgtctgatgt 2125201 attgacaaca agtgtgtcgc cttcattcac aaagaacggc acgtttacaa caagcccggt 2125261 ttcagttttc gcaggttttg taccgcctga cgctgtatca cctttaatac caggttcagt 2125321 ttcaacaact ttcagctcaa ctgtgtttgg aagttcgata ccaagtgttt catcctggta 2125381 catcatgata tgcacagaca tgttttctag caggtatttt aattcttctt cgatttgagt 2125441 tgcgctcagt tcaagctgct cataagaaga agtatccata aatacgtgct gatctccgtt 2125501 tgcatataga tattgcattg ttttggtttc gatttgcgct ttcgctactt tttcaccagc 2125561 gcggaatgtt ttttcctgaa tcgcgccagt gcgaaggttg cggagtttag agcggacaaa 2125621 tgccgcacct tttccaggtt ttacgtgctg gaagtcaacg acgcgccaaa tgccgccatc 2125681 tacttcaatt gttaatcctg tacggaaatc gttaactgaa atcatgttta atgtcctcct 2125741 atattccaat cacaaaataa taagttcttt tggggaatgg gtgattgtcc ggttgccgtt 2125801 ttctgtaatc acgatgtcat cttcaatgcg gacaccgcct gtttctggta tgtaaatgcc 2125861 cggctccact gtgaccacca tacccggttc aaggatagct gaagatctga cggataatcc 2125921 cggcgattca tgaacttcca tgccgagccc gtgcccggtt gaatggccga aatagtcacc 2125981 gtagcctttt gcagcaatat gatcccttgt gagggcgtca gcctcttttc ctgtcattcc 2126041 cggcttaata tgtgcgacgc caagcgcctg agcatcaaat acaacctgat agatctcctt 2126101 caattgatca ctgggctgac ctacagcgac cgtccgggta atatcagaac aatatccttt 2126161 ataataagcg ccaaaatcaa gcgtaacaag gtctccgctt tcaatcagtt tgtcactggc 2126221 cacaccgtgc ggaaggcttg aacgaaggcc tgaggcgaca atcatatcaa aagaagagct 2126281 gtctgctccc tggcttctca tataaaactc cagctcattg gcaacagcga tttcagaaat 2126341 gccgggtttc ataaacgtca agatatgtct gaaggcatca tctgcaatct tcgcagcttc 2126401 ctctaatatc ttaatctctt cactagactt aatcaagcgc aacttttcca cggattcagc 2126461 cacaggcact aattcggcat cactgataac ggcgctgtat gaagcgtaag tgccatatgt 2126521 catgctgttc tgttcaaagc cgagacgctt gatgccaaac gattcaacag tgtcggcagt 2126581 ggtctgaatc aagctgccgc catgttcaat gatctcaaaa ccctttacct gaaccttcgc 2126641 ctgctcagta taacgaaaat ccgtaataaa cgctgctttg tcacccgata taacagccaa 2126701 acccgccgaa cctgtaaacc ctgtcatata gcgtacatta gtgttgcttg taatcagcat 2126761 gccgtcaatt cccagctgtc caaacaggtt tcttaatttc tctagcttca tcttgattct 2126821 cccccttgct ggcttaataa gtagcgaaca gcaagcttgt agccttcagc tccaagaccg 2126881 acaatctgcc ctttcgcaac aggagcgata accgactgat gcctgaattc ttccctggcg 2126941 tataagtttg ataaatgcac ctctaccaca ggaagactga tgcttgaaac agcatccctg 2127001 atcgcatagc tgtaatgact cagggcgccg gggttcagaa caatcccgct gtattgctcc 2127061 tcagcctcat gtatcgcatc tatcaaatca ccttcgtgat tagactggaa gaaagtgagc 2127121 tggatatgta aggcttcagc aaactgaaaa agatctgttt caatatcggt cagtgtctgg 2127181 cggccgaata cttcaggctc acgactccca agccggttaa cattcggtcc gttcaaaatc 2127241 aaaaaatgag gcacacaatc tctccttttc gcgagggttt ctcatgtaaa aaatgttcac 2127301 ttctcgtgaa cattttatca tactggaaaa ggattataca ctattctcta tgcattccca 2127361 gcgcacgtgc aagcttttcc gaattcagct cattgtattc aaatgaaata gaatacccga 2127421 caaacagccc gtaaagcaaa taaatgcaaa tggtcgtaat aattgtatct gatgtcagtt 2127481 cggtcaccgt gcgcacatct ggaaaaatcg gattaaaaac aaaaaacacg agcagccaaa 2127541 gcaccaagcc gtataaaata cccggccaca ttgtttttaa acgtttcaat agaagaaaat 2127601 aaagaaatgc tgcgccaatt gaaattactc caatcaaaat gatgctgatt accgttccca 2127661 gcccatgttt tttccactct ccgagtacaa acggctgcaa tatcatattc gggctgattt 2127721 cggaaaaatg aaacaaatat gcgatataag caacgaaact ccaaagtacg cctccgcaaa 2127781 aacctgttgc cgccaccctg ccggccattg aaacaggcgg cttttgcttc tcattcaatt 2127841 cttcattttg ttctgtatct ttttcgcttg tcatcatggc acctccagtt aaagtgtgcc 2127901 caaaaaatga aatgtcaata aaaaagctca cactttttgg cagctgcgag taaaatttga 2127961 aaataacggg tataatgcat gtagaaaaag caaggctatg gcaatttttt cagcctgtca 2128021 atctagaggt ttagcgctgt ttcctgtaca atagagtgaa aggaaatggt tagcaatcct 2128081 aaagaaatag gcaggttgat aatatgtcaa aacataaagt tccgcccgct tacggcgggc 2128141 aggctgttgt ggaaggcgtt atgtttggcg gaaagcatca ttacgttaca gccatcagaa 2128201 gaacggatgg aagcattgac ttttttaagc ttccacgcaa acacaacccg aaactgaaca 2128261 tcgtgaaaaa gataccgttt ttacggggga tcgcggccat tatcgaagcg agtgcaaacg 2128321 gcacaaagca tttgaatttt tcaagcgaac gttacgggct cgatccatct gaagacgaga 2128381 cacttgagca ggaagaaaaa aaatcctctg ggctgtctat gtatctcagc ctcgcagtta 2128441 taggcgtcct atcatttttg ttcagtaaat tcgtatttac attggttcca gttttcttag 2128501 cggaactgac aaggccgatt ttttccttga acacagcgca aatcgcgatt gaaagcctgt 2128561 ttaagttgat tttgctgctc ggttacatct attttttgtc catgacaccg cttattaaaa 2128621 gagtgtttca atatcatgga gccgaacata aagtcataaa ctgttatgaa cagaatttgc 2128681 caattactgt ggagaatgtc caaaaccaat ctcggcttca ttaccgctgc ggatcaagct 2128741 ttattttatt tacgattatt gtcggcatgt ttgtttattt actcgttccg acagatccgc 2128801 tttggctgcg tgttatagat cgtgtcgcac tgataccggt cgtgcttggt atatcctttg 2128861 aagttctgca gctgacaaac aaagtgcgtg acattcccgg tctgaaatta cttgggtacc 2128921 cgggactttg gcttcagctg ttaaccacaa aggaacctaa ggatgaacag gttgaagttg 2128981 ccatcgaaag ctttaacgaa cttctcagac tcgaagcatt gtctgagcaa aatcagaagc 2129041 cttctcacaa cgtcatctaa aatccgttgc cctgctatta ctttcggagg tggacagtta 2129101 tgaatcatcg tgtacaacct attattgctg tattaattgc gctgggagcg ttcggtttcc 2129161 tctatgtgct ggtaaccaat cccggagaaa tggcaaaaat ggcggtaacc gtcatcgtgg 2129221 caggtatcat tatttatttt attgtgaaat atgtaatgaa tcgaaatgcg ggcagcgaag 2129281 gagcagcctt caaaaaagcg gcgaaacaat cacggcgccg gatgaaagaa caaaaagcaa 2129341 aacaccgcgc cggacataag ggacgtgtca gccacctgcg aagcgttccg agcgccagca 2129401 agcctaagcc gatgattctc aagaaaaaaa gccagactca gctgactgtt atagaaggga 2129461 aaaaaaataa aaagaaaaac agagcgcttt tttaataggt ccactgcttt aaaaacagct 2129521 ctgtccgtct tttacctagc tcaatcaggg ctagtttttt ttgttgtgtt aaatgaaaat 2129581 cagtggccat tacgtcatca acagggagaa aaatgatatt ttgttcatag cgtgacgcaa 2129641 tgtgccttgc gtcatgagca tccttcatcg tttcaaacag ggcgccgaac agttcaaaag 2129701 cgttgcggat attttttttc ggacgctctc tttcacgcgg cgcaagcgtg acaccgatca 2129761 cagggcgctt tctttccttt gaaaacagcc agattggaaa attgcttaac acgcctccgt 2129821 cgacaaccgt ggcggtgcct gtgtccgttt ttaattttat cggttcaaag aaatacggaa 2129881 tgctgcagct cattctgacc gctctggcaa ccgggaacat atctggattt aacccgtaac 2129941 gggccaaatc gtccggcaaa acaatcatgg tgccgtttgt cagatcagaa gcaataaggc 2130001 gcagagaccc tttctgcaaa tcgccgaaaa cccttatgcc tttcgctctt aacagatcag 2130061 caatccattt ttctatcgta tcgcctttgt ataagccaag acgccagtag atggacaccc 2130121 actggagcat ctttaagggg agaaatgagt acctctgatc cagcaatttc tctccgtcca 2130181 cttcttcaat taaagcgtgg atttccttac tggtgtaacc tgacgcaatg aaagcggcaa 2130241 taatggcgcc ggcgcttgta cccgcaactc ttttaaagcg gaagcctttt tcctcaagca 2130301 cttcataagc gcctgcgagc gcaatgcctt ttactcctcc gccggaaaac acaccgtcaa 2130361 tatacatctc attccctccc cctccatccg atcgtttatt accattttaa gaaaacacgc 2130421 gaagaaatag accaacgaat gacgggtggc gtcagcgtat caaaaaagac ggcctccttc 2130481 gagaccgcct ttttactgat tatgatgttc tgttttcttt tggattgatt tcagatcttt 2130541 tttacgggca tcatcttctt caaaatattg aacaagatcc ccgatgcgat caatactgtt 2130601 ccagcttaaa tgatgttcga ttccttcgac atcgttatat attttctctt catcaacacc 2130661 aatgattctt aaaaactgct caagcaattc atgtctgtat accagccgtt tgcctatttt 2130721 tttcccttta gacgttaaca cgagaccgcg atatttttca taaattaaat attcgtcttt 2130781 atctagtttt tgaaccattt ttgttacaga ggagggatgg actgccaatg cttccgcgat 2130841 atcggaaact cgtgcatatc ctttttcttc aatcagcata taaatctgtt caatataatc 2130901 ttccatactt ggtgttgtca tcgaaaccct cccaaaaagc accttaactt tataaaccat 2130961 tacaagttta cactaatgaa cttgaaaaaa caaggatgct ccgcgggtca aaagccctgt 2131021 ttaccgctta taattccatt catctgaagc gtactttgtt tcagccaagt gatgaacaaa 2131081 atcaagctct tcctgagaaa gttcatatgg ctccaaatga atgttaagac ctgtttcaaa 2131141 tccttcttta aaggctttac gagcctcatc catcgtcacc cgcttttcga tgagttcatt 2131201 aatggcaacc gctttatttt tgaaattgcg ctgcatccgc tctcttactc tttcacttgg 2131261 atataagaac agatcgaaca gcttgtcctc atctaaatca agaagaatgg agccatgctg 2131321 aagaatcaca cctttttgtc tcgtttgcgc gcttcccgcc accttgcgcc cctcaaccac 2131381 tagttcatac cacgaaggcg cgtcaaaaca aacagatgac cgcggatttt ttaagctttc 2131441 tttttctttt tcagttctcg ggatggcaaa gtaagcgtcc agaccgagat ttctaaagcc 2131501 ttgaagtatg ccttctgaaa taacccggta agcctcagta acagtcgccg gcatctcggg 2131561 gtgctcttcc gaaacaatta cgctgtatgt cagttcctga tcgtgcagca cacctctccc 2131621 gccggtcggg cgtctgacga atccgagatt atatttatgt actgcttcaa aattgatttc 2131681 ctttttaata ttttgaaaat accctacaga aagtgtcgcc ggattccagc cgtaaaaacg 2131741 gataaccggg gggattttct tttcgctgtg ccaatataaa agcgcttcat caagcgccat 2131801 attgaatgca ggacttgcat tgcctgagtc tataaaccgc caagtttctt tttgcatttt 2131861 aagaccttcc ttaccgtttt aatagaatca gtttatcaaa ctgtcgggaa aatgaaaaat 2131921 attttagttc cattatagat gacaatcacg ctgtgcttta ctataatagt atttgtcgaa 2131981 aacggctcta tgaccttgtt ttatgaagca gggttttgat tttatatgct aaaggagtag 2132041 aatcacattg tctaatatga tcgttttgat tatttttgct gcatttatca tctatatgat 2132101 tgcttcatat gtctatcagc agcgaattat gaaaacactt accgaagaag aattccgcgc 2132161 gggttaccgc aaagcgcagc ttattgatgt tcgtgagcca aatgagtttg agggcggaca 2132221 tattttaggc gcccgcaaca tcccgctttc ccagctgaaa cagagaaaaa atgagatccg 2132281 tacggacaag cctgtttacc tgtactgcca aaacagtgtc cgcagcggac gcgcggcaca 2132341 aaccctgcgc aaaaacggct gcactgagat ttacaaccta aaaggcggct ttaaaaaatg 2132401 gggcggaaag attaaagcga agaaataaag caaacagctg tctggtagac agctgttttt 2132461 atttatcttt cttccgcctc gtatctgagc actgggtgtc tcgccgcttt tgtttcatcc 2132521 attcttttta caatcgttgt atgcggggcc tcctgaacaa gctccggatt ctcctccgct 2132581 tcttttgcga tttgaatcat agcatcaata aacgcgtcca gtgtttcctt tgattcggtc 2132641 tctgtcggct cgatcatgat gcattcttca acattaagcg ggaaataaat cgtcggcgga 2132701 tgatagccga aatcaaggag ccgttttgca atatcaagcg tacgcactcc cagctttttc 2132761 tgccgcttcc ctgataatac aaattcatgc ttgcaatggc ggtcaaacgg aagatcgtaa 2132821 taaggcgcga gttttctcat catataattg gcgtttaaca ctgcgttctc agtaacagcc 2132881 tttaatccgt caggccccat ggagcgaata tacgtatacg ctctcacatt aatgccaaag 2132941 ttgccgtaat acggcttcac acggccgatc gcatgagggc ggtcataatc aaacgtaaag 2133001 cgcccttctt ttttgactaa aactggcttt ggcaaataag gaatcagatc ttgttttacg 2133061 ccgacagggc ctgagccggg gcctccgccg ccatgagggc ctgtgaatgt tttatgcagg 2133121 ttgaggtgca ccacgtcaaa tcccatatca ccaggtctcg ccttgcttaa aacggcattt 2133181 aaattagcgc cgtcataata cagtttcccc cccgcttggt gtacaatttc cgccatctct 2133241 gtaatctgct cctcaaacaa gccgagcgtg ttcggattcg tcagcataag agctgcagtt 2133301 tcttcattca ctgctctttt taaatcctct aaatcaacaa gccctttttc attcgatttc 2133361 accgtaacgg tttcaaagcc tgctactgtt gctgatgcag gattcgtccc atgcgcggaa 2133421 tcagggacaa tgaccttcgt ccgcttgaaa tccccgcgag cttcatgata ggcacggatc 2133481 atcatcagcc ccgtccattc gccgtgcgct ccggcagcag gctgaagcgt aacctcatcc 2133541 attcccgtta tttcttcaag gtgtttgctt aaatcatata aaagctctaa tgcgccttgc 2133601 accgtgtctt catcctgaag aggatgaatc gcagcaaaac caggaatacg tgcgattttt 2133661 tcattgattt tcggattata tttcatcgtg caagaaccga gaggataaaa accggaatcc 2133721 accccgtgat tgcgtttgga cagcgctgta taatggcgca tgatgtccag ctctgaaacc 2133781 tccggcagcg ctgcgtcttc gtcacgaata taggtgtctg acaagaggtc ccccaattcg 2133841 atttccggta catcgagctc cggcagacta tagccgattc ggccttctct tgaaagttca 2133901 aaaataagtg cctggtcctg attactcatg gcgatccccc aattcctgaa tgagtgcgtc 2133961 aatttcttct tttgttctca gctctgttac agcaatcagc atatggcagt ccagctctgg 2134021 atacgtcaac ccaagatcat atccgccaat catgcctttt gccagcaaac gcttgttcac 2134081 agctctcacc ggctcatcca gtttgatgac aaattcatta aacatcggcc cgtcaaacat 2134141 aacagtaagg cctgcttttt ttgcttcttg ctttgcatag ttggctttta agagattttg 2134201 gcgggctata tcttttacgc cgttttttcc gagagcagtc atggccactg atgctgccag 2134261 cgcatttaaa gcttggttcg agcatatatt tgatgttgct ttatcccggc ggatatgctg 2134321 ctccctggct tgcagggtaa gcacaaagcc tctttttccg ttttcgtctt ccgtttgtcc 2134381 gacgagacgg cccggcacct ttctcattaa ttttttagta acggcaaaaa agccgcaatg 2134441 cgggccgccg tatgctgaag gaatgccgaa aggctgcgca tcaccgacga cgatatcaga 2134501 ctgaaacttg cccggcggag tgagaagacc tagcgccagc gggttggctg aaacaataaa 2134561 catggatttc ccttgatgag cgataggctc aatatccttt agcggctcga tcctgccgaa 2134621 aaaattcggg tactgaacga tcactgcggc tgtgttctcg caaacggttt ggcgcaatgc 2134681 atcaagatcc gtaacgccat ccgcagcggg tacttcaaca acatcaatat actgaccttt 2134741 tgcgtaagtt ttcagcacct ctcgcgattc aggatgcacg gtttttgaca caacaatttt 2134801 tttctttttc gtgtggcctg aagcaagcat tgctgcttct gccaaggctg ttccgccgtc 2134861 atacatcgag gagttggcga tatccatgcc tgtcagttca cagatcatcg tttggaattc 2134921 aaaaatagcc tggagctctc cttgtgaaat ctctggctga taaggcgtat atgcggtata 2134981 aaactcagag cgcgaaatga catgatccac aatgacaggc tgatagtggt catatacacc 2135041 cgctcctaag aaagaagcgt attgtacggt atcacgattt ttagaggcca gctttgtcag 2135101 ttctcttgtt aattctgtct ctgatttcgc ttttttgatt tgatgctctt ttttatattt 2135161 gacgttttcc ggtatatcag caaataaatc atcgatgctg cttacgccga tagtagcaag 2135221 catctcctgt ttatcctttt ctgttgcggg caaataacgg tgcttcatgt gttgtctcct 2135281 ctctccaaga aaaaatatta gcgtttataa aatggtgttt tgacaacctt tgctttcact 2135341 aattttttgc gtatctctac atctacaaca gtcccgatct cactcgtttc cgaatcaatt 2135401 aaggcaaggc cgacgttttt tcctaatgtc ggtgactgcg tgccggttgt cacctttccg 2135461 acagacttgc cattttggaa aacctcatat ccgtgccgcg gtatcccttt ttcaatcatt 2135521 tcgagaccga caagtttgcg cttcgctccg ttttcttttt gttcactcaa tactgactta 2135581 ccgaaaaagt cagactcctt tttgtgcttt acagcaaagc ctatacctgc ttcaatcggt 2135641 gtaatatccc gggtcagctc ctgaccgtag agcgggagct tcgcttcaaa ccggagtgta 2135701 tcacgtgcac cgagaccgca tggaatcaat ccgtatgcat cccctgcatc gatgattttt 2135761 ttccaaatat gcatagcatc atcactgcgg cagtaaattt catacccgtc ttctcccgta 2135821 tagccagtgc gtgaaataag tgctttgcgg ccgctgatat cggcttcatc aataaacgca 2135881 aacggcttta atgcagacac atccgcatct gtcagatttt ttaagatcgc ttctgctttc 2135941 ggtccctgta cagccaagag cgcgatttga tctgactgat tgtcaatctg cacatcacct 2136001 gctgcatgtt ctttcatcca agccaagtct ttatctatat tagaagcatt aatgacaagc 2136061 agatagcggt tctctccttt ttgatagata agcaaatcat cgacggttcc gccatccggg 2136121 taacacatcg ctgtatattg agcacggcct ggcgttaacg cggaaacatc atttgtcatc 2136181 aatctttgca aaaaagacag actgtcgttc cctgacactt cgacttctcc catatgagat 2136241 acatcaaaca aaccggctgc agttcggaca gcctcgtgtt ctttttttat agaagaaaat 2136301 tgaacaggaa gctcccagcc tccgaaatca atcgtttttc ctccatattc cttatacagg 2136361 tcaaataacg gcgttctttt cagcatctaa ttcctcccct ttatcaacgg cgcagctaaa 2136421 aaacatacaa aaaaggacag agaaacacct catgtaaaat gaaggttctc tgtcctggca 2136481 cctgaaagtt tactttgcat acgcaaagac gtcccctttg gtggtttgcg catccgcaca 2136541 aacactctcc agagttgcgt cgagcaagag ttcttttgcc tgagagattc actccgcagt 2136601 ttgctccttc ggcgcctgta tcccgaggtt ttcggtcagg tctctcccct tgctgtcatt 2136661 cgctcatatt ttcatgctgt tatggacata ctatagcaat atcttacatc aaatacatac 2136721 tcatatccta ccatcatcac tatatgctgg gcaacagcaa tttgggcaga tttttcttat 2136781 attattcatc ttaagaatcg aagaataaga aaggcggttt caaagcaatg aatacagaaa 2136841 tgatctacga tgcaaaatgg cctgaagaat ttgctgaaag actgaaaaac gatggccctt 2136901 gggcaaactg ggaactgtac aagctctctg cagaaatcca gaaaacatta gcaattccag 2136961 agtttgaagg cttacgggct cctttatatc tgccttcctt tacgccgctc ccccaccagc 2137021 ttgaagtggc gcaaaaagtg gttgaaaaaa tgaacgggaa agcgatttta gcagatgagg 2137081 ttggtctcgg aaaaacggtt gaagctggac tgattctaaa agaatatatg attcgcgggt 2137141 tagcaaaaaa aattttgatc cttgtgcccg cttcccttgt gtcacagtgg gtcaaagagc 2137201 ttcaggaaaa atttttgatt ccggctgttg aacaaaagaa aagctatgtg tgggagcaat 2137261 gcgatattgt cgtctcatca atagacaccg cgaagcgctc gccccatcga gaaatcgttc 2137321 tgtctatccc atatgatctt gtcattattg atgaggcaca caaactgaaa aatagcaaaa 2137381 cgaagaacta tgaatttgtc cggaatctcg taaaaaaata ttgcctgctt cttaccgcga 2137441 cgccaatcca gaaccgtatc gaagagattt tcaatttggt gtccttatta aaacccggcc 2137501 atttaggcag tcagaatcac tttcaggagg agttcgccaa gaagaaatcc agtttagaag 2137561 cgcatgaaca tttaaaagat cttgtgaata aagtcatgat ccgtaacagg cggcatgata 2137621 cagggctgaa ttggaaacag cgccatgttg aaacagtgcc gattcaattt tctccatcag 2137681 agcaggcgct ttatgatgaa atttctcgtt tgaaggacag tatcaataaa ccagccagca 2137741 tgttctcgat tatgaccttg caaagagaat gctgttcgag cagagaagcg gtatatatga 2137801 cgctgaaaaa gatgcttgat caaaaagaga aacaagcacc tgccattgat gaggatacga 2137861 tttcagtttt gatagatcgc atcaatcaag tgacacaaaa ctctaaagcg cttcaagttg 2137921 ttgacttgat caaaaagatc gacgataagg tcatcatttt tacagaatac cgcgcaaccc 2137981 agatttatct gcagtggttt cttcagcaaa acggcatcag ttctgtgccg tttagaggcg 2138041 gatttaaacg tggaaaaaaa gactggatga aggatctttt ccgcggaaaa atccaagtcc 2138101 ttattgcaac tgaagcaggc ggtgagggaa ttaacctgca attttgcaat cacatgatca 2138161 actatgacct gccatggaac ccgatgcggc ttgagcaaag aatcggaaga attcacagac 2138221 tcgggcagga gcgtgacgtg catatttata acatggcgac aaaacatacg gtggaagagc 2138281 atattctaaa gcttttatat gaaaaaattc atttgtttga aaaagtggtc ggtgaacttg 2138341 atgatatttt aacgaaaatt caagtgaaca attttgaaga gcaccttcat gacattttgt 2138401 atcactcagc aacagaagaa gaaatgaaaa taaaaatgga taacttaacc tcatttttgt 2138461 cttataaaaa acagctgcct gctgaaaaaa gaggatctta gcctgtaagg aggttttatt 2138521 agtgagacag caagaggttc acgattttct gctgcgtttt tttcaagcaa acagctgcca 2138581 aatcgtcgat caaggcttag gctatatgac agtgcagctt acagttgaaa tggacaaaca 2138641 aatcatgaac cgccctttct actggcattg gcgcgagaag acaggcggtg atccgaatcc 2138701 aatgaaaatc acttttatta cagataaaga aaatgcgcca aaagacctag atggtgaatt 2138761 tatatatttt ggggccccgc gtctttttca aatattcaaa gctgttaaac aaaatgggag 2138821 atttaccaga atgtatgaga aaattgaatc agccggagct aaagtcccac ttcagccttg 2138881 gcttggtata aatgtcacga tttcatacca gtccgacatg aaaaaggata agttattgtc 2138941 actaggtctt cacctagtct ctggaacgat aattgaagat tttcaaagca agctgaccca 2139001 gttttcactg acgtctcaaa tatgtgacta ttgcttcacc atttcaccta tgatcaaacc 2139061 agaaagcgga cttaagcgta tggaaaacta tatttccaaa tccgctatgc aggagccgtc 2139121 cgactgggcg gaacaggcgg ttaacaggtg gaagaatgat atgacattgc ttgataagtt 2139181 ttacgagcat atagaagaaa aaccagaaga ataccatcta gaaaaacagg cgctgaaaac 2139241 cttgtatcaa ccaaagatat cagttgaaat tgaaaatggc ggattgtttt atctgcaaaa 2139301 taatatttca agctaacttt tttaccattc gacatcattc tcgttttttt tgagaaaata 2139361 cgattataat aaaggtatat tggaaaaaaa ttctggtgat ttaatggcaa atgacttcca 2139421 gagactaatg aagcatacaa taagtcatgg ccggactggc tgaaatacat aaacaagtat 2139481 tttaggagga gaaactgcat gaagaatgca aaacaagagc actttgaatt ggatcaagaa 2139541 tgggttgaat taatggtgga agccaaagag gcaaatatca gcccggaaga aatacgaaaa 2139601 tatttacttt taaacaaaaa gtctgctcat cctggtccgg cagccagaag tcataccgta 2139661 aatcctttct gaatgtgcta taatatcaca aggaaggtga tgacattgat tggccagcgt 2139721 attaaacaat accgtaaaga aaaaggctac tcactatcag aactagctga aaaagctggg 2139781 gtagcgaagt cttatttaag ctcaatagaa cgaaatctac aaacgaaccc ctccattcaa 2139841 tttctcgaaa aagtctccgc tgttctggac gtctcggttc atactttgct cgatgagaaa 2139901 catgaaaccg aatacgatgg tcaattagat agtgaatggg agaaattggt tcgcgatgcg 2139961 atgacatccg gggtatcgaa aaaacaattt cgtgaatttt tagattatca aaaatggaga 2140021 aaatcccaaa aagaggagta gtgcctgagc agaggcacta actcctcttt tgtcaataac 2140081 catcgagacg gcccagtata tgaatactgg gccgtctctt ttttttgctg ttattaattt 2140141 ttatcctcgc tatgcgcgag ctcgtcttgc tcagtattgc tcattttttc aattttttag 2140201 aaatttttgg gattgttatg tgagaattta aatgcatatc ccattattat ttggtaataa 2140261 taaacaaaga aagggtgaca gcatgatgat caaacaatgt gtgatttgtc tatctcttct 2140321 cgtctttggc accacagccg ctcacgcaga agaaacaccg cttgtaaccg cccgccacat 2140381 gtccaaatgg gaagagattg ctgtaaaaga agcaaaaaaa aggtacccgc tcgcacaggt 2140441 actgttcaaa caaaaagtat gggaccgtaa aagaaaagat gaagcagtga agcaatacca 2140501 tttaactctg agggaagggt caaaagaatt cggcgttttt gtgacgattt catttgatcc 2140561 ttatagccaa aaggtcaata aaattgccat attagaagaa tatcaataag gtcctccatt 2140621 ttttgaagga ccttattcgt ttatttgcgg ttattttttc cgtttcagcc aaagtcggaa 2140681 gccatagggt aaaataccga accactgctg ggaaacaggc gtttttgttt ctttccgcac 2140741 ctcttttcgt tcttttcgct catctctcgg agtatctata tatttgacaa attgctgcgt 2140801 catatattta acataatcat tcgttttcac gtgatcacct catcattcaa ttattatgag 2140861 tgttgtctca catgactttt tttataccct ttacactgtt ttattctgtc catctcagca 2140921 gttttttctg tttttggtca aacacgatct gtgcagttct ttctgttccc gaatccgttg 2140981 acactcttaa gttgatttct ttttgttctt ttatcgatgt atcatgaatg taataagaaa 2141041 cccgtccata tagaaattgc tgcgtaccct cctggccttt ccgttcctct agaacatgcc 2141101 gaatcgaaag aagcacccca ttttgaagca aattctctcc tatgtataac tcttttgttt 2141161 ccttctcaaa catgcagcgt gaaatatatt gagcagcaac aaagttcacg attaacagca 2141221 caagcgctga cacaaaaaga acagctggat aaataaaccc tcttgtacga tacattcacc 2141281 cccctcctaa atacgaatag actggaaaag cagtttgata cactttttgg tcttcactct 2141341 caattttcag caaaacaaca ccattttcaa tatcagcttt catggcagta atatgatcta 2141401 aaatcggaac atgccctttg ccatccactc tttttcttat cattgaatga taaatgtcaa 2141461 aacggatgtc ttgtccggaa agattggtgc agattaacac gctcccatgc tcggctgtct 2141521 taactgcctg tgattccttg cattcattca tcatctgttc tatcgaaatc atccattcct 2141581 gctgtgtgaa accgtcatgt tcctgctgtc gagacaaaaa cagatggata atcgcagcta 2141641 acgatcctga tatgagcaaa aagactgaga gcgaaaataa tacgttaaga agcgtgtagc 2141701 cattctgtct gcaaaatgct gaggcaaaat gatttttctt tataagctgc ggctttgata 2141761 catacgtttt gatattcgcc ctcctcctcc cacttcattg catagatatg attgttcttt 2141821 gtaatcgttt ttgacgcggc tccttcacca ctcatgacat atttgctaat gctctcattc 2141881 atcatctgat agccaatttc tcgtgattcc gccatttttt catcagccat cagcttgtcc 2141941 cacaagggga cgactgtcag cagcacaaac agccacaggc ttagcgcaga cattgtttct 2142001 attgtagaaa aacctttatt ttctctccac attgactctc ccgctcccta gataaactgt 2142061 tatgtcataa acggcatggc cttttactcg tatttttccg cctgcattcg ggtgcccttt 2142121 ctcattaaat tccaaacggt cttttaatgt cagcagttct atagaaagtc ccgttgcata 2142181 cggacgttca ataaccgtat caccaatgac taattgatat tcttttttat gaaagagaat 2142241 ttttgttctt tgttgacggg aaatagcagt ctgctgtgtg agcataatat catttttcag 2142301 ctgacttgct gcctgtcgga cagctgtatt gtcataagca ggaggaagtg tagtgaagac 2142361 ggccaccagg aggatagagg caaggcttaa cacaagcaaa ctttctaaaa gggtaaaccc 2142421 cttctcctcg tttaatttaa tgttcaacct taacttctcc gccggtgatg ataatgcgct 2142481 taccatttgg acagacagca tcctttttca catagccctc tgactgtaaa tcggcaaggc 2142541 tcggagtttg tccttcatga tcaagctcaa atgcagtcat ttgtgcctta accatgtttt 2142601 gtaagccttc acagcccttt ttttgaatgg tttgattatg tttcgtgacg ttcggtatcg 2142661 taattaaaag caaaatcgaa ataataaaga gcacgattaa catttcaaca agtgtaaatc 2142721 ctttctcatt catcagcctc ttcctttcac atttgattca tcatctgata cataggcaca 2142781 agcatagata aatacacaag taagatcatc gctgcaacaa atccataaat cattggctga 2142841 aggatgcctg tccatttttg cgctttgtgt tccagccgct gtaatatgaa ttggctgtat 2142901 gtgaaaagct cccgatccaa tcggccgctc agctggccgt gagatatgac ttttgataaa 2142961 tcagtttcat aaaaaaggct tccacaaata gcggattcaa ttgactcacc ggcttttagc 2143021 cgttcaatca attgttcagc ctcgcagcgg tagaaaggga gaaacgtttg atgtttaaat 2143081 gcattaaggc tgtcataaat tgagaggcct gattttaaaa ggctgcttag ctgcaaagaa 2143141 aaaaagtagc tgttaaacag ctttacaagc tttccaacca aaggaatcct gatacaaatc 2143201 agcatttgcc gggcaggtga ttttttctta aacacaagcc aataataaat cccgatacct 2143261 gctgtaaaaa gaacaagcaa aatgatcaca agatcaatat gctgaaaaaa agcaaaaagc 2143321 atatcggttg aacgtgaggt ttccatattc atcgattgat agataccgga aaactgagga 2143381 atgatgatgg actgtaacat ataaaacatg acagcgaccg taaagatgag gaaaagcgga 2143441 tagcgcagca ctcttttcag ctggtctgcc tgtgcaattt ttcgttccag cagctctccg 2143501 ctctggatca ttgaagcagg cagttcacca tgtgtttcag caaaataaca aatacctacg 2143561 gcttccttat gaaatgacaa actctttagt acttgataaa acggagcccc ttccctcaaa 2143621 caagtgaccg aatcagtcaa gtcagccgcc tgcctcttat tcatctgaag ttccatcagg 2143681 cgtaatccat ccagaagtgt atatccgccc gcagtcattt caccgagcct ctttaataac 2143741 ctggcttgat cctttaacaa ccagactttt ctaatctttt tcatgataaa cccaccggtc 2143801 atagttgttt gtcgttaaat agccgagcgc aattcctttt ctgataattt gacgaagcgt 2143861 ttgatattgg taatttgcat gatttccttt tgcctcctgg atacattgct gaagattttt 2143921 cccgtataga agctcataaa cgctagctct cctagtattt cgtgactgtc ggcaatacac 2143981 tgatgaacat ccgttttcac aaaacgggca agccaaatca accaagcgct gagccgctat 2144041 tgcaatgaca gtctgttcga tttcattcat attgataccg aattcaagca gtctgtaaat 2144101 tgcgcccttt gcgtctctcg tatgaaggct cgttagtacc agatgtcccg tcatcgctgc 2144161 ccgcaccgca atttcagctg tttccgcgtc tctgatctca cctaaaataa tcatatcggg 2144221 gtcatggcgc aaaattgctt tcagacctgc ggaataagtt acaccggctt tttcattcac 2144281 ctgaacctga agaacatctt cgtcccttgt ttcaacaggg tcctctaatg tgacaatatt 2144341 tcgattaaag tgtttttttg catattgaac gagagagtat aatgtggtag tcttccctga 2144401 accagtcggc ccggtaaaaa tgagcatgcc atgggaatgt tttaaaaacg agagtaatgt 2144461 ggctcctgtc ttcggaaata gcgacaattt atcaatcgaa gggatattgt attggggcat 2144521 cactctgatc acgaggcttt cttcattaat tgtgggcagc gttgacattc ttaaatgaac 2144581 atttccctct ttcaacttta acgtaagcga accgttttgc ggctttcgcc tttcacctat 2144641 atccattgct gaaagaaatt taaaatgtga aatcagtctt acgcactctt cttttttcat 2144701 gtcccttttt ttcagcaagg catgatcgac ccgaaaatga atgatagcgt cccgctccct 2144761 cggcacaatg tgaatatcag aagcctttgt tagatatgcc tcttcaatca agtttttgct 2144821 taccttttct attgaatcca atttgattcc ctctcctttc aacgcatatt gtagaaaaag 2144881 aagaaaaggt aatcaaacag ggaaaacgtg attttgtgag atgttatatg ctgaaaaacc 2144941 aattctttct ggcaagaaaa aagactttca actgaatgta cccctgtcat tataattttc 2145001 cctataaata aaaaagcaga catggtcacc atgcctgcta gattccattt tcattatgct 2145061 gttttcgctt attgaccagt atctttctca acggaaagat cgcctaatgc aacaataccg 2145121 gtcatttggt cattttcaag aatcgataaa ctgcggattt aatgctctgt cataagcccc 2145181 ttgacatcgt atccggtcac cctgatatgt ctggtgaaaa agcggggcac gctgcacaaa 2145241 atatgaaaca tcctatagag tccgcctttt tcgaggtttc tttttcttct tccgctcctg 2145301 cagcatatct cccgtccagc ctttttttct caaatagaga tagatcagaa ctgtagatgt 2145361 gacaatcaat aagagggaaa agagatatcc gtatttccaa ttcagttccg gcatcactga 2145421 aaagttcatc ccccataagg cacccagagc tgtaatcgga gtaaaaagcg tcgtgaaaat 2145481 ggtcagcgct tttacaattt cattccccct atgtgaggta atgacttcct ctgaatgcag 2145541 cagattgtta agctcccctt caaattcgct gatgtatgta aatcccctgt caatcttcag 2145601 ttgtgtccgc tgataatcct ttttcccttc attttgaggt aaaaaggttt ctttcaacgc 2145661 catttcaatt tttttagcgc ttaatatcaa atttttccaa atcatcagtt catggcgcag 2145721 gagatggacg cggtttaaaa tgcttttgct attgtcgtct ttaatttgcc atctgagctt 2145781 tctcagcttg acttcaaatt catcaacacc gattaaatac gcattcatta gttcgccgag 2145841 aagaattaaa aacccctcta tcgcattgtc cgctctttcc atttgccgaa caacttcttt 2145901 gcctttaatc tctctcaaaa ttgaaaagtc aaagttgatt gtaaaaaaat attgtctggt 2145961 gatataaaag tgaaaaacag tatggtcttt ttcttcacca agcccctgat cataaacaat 2146021 cgacccaaat actgcttcat tttccgtttc agttgtatct actcgcaaaa aattaacgtg 2146081 atggttattt tcaaaccact tttcacactg aggccagtga gaaaaatgga ttagatctct 2146141 tgccttactt ctttcttgag gccccatttg gtaccaaaac caatcctttc ccgtatgtgc 2146201 cttcatgtca agctcctcca aacttttgtt ctttattctt taattgccca ataaccgcgt 2146261 cactaaacca gtctgccgct tcaacacatg ttttatgagc attttcaggt ggtatggaat 2146321 gtagaaagac atcggaaaag ggaggtgcat gccttccttg gagaaggcag ttgttttgga 2146381 atttatcaat ttactagcag tcgctattct cattttgtta acaggatttt tcgttgccgt 2146441 agaattttca atcgtaaaag tgcggcgatc caaaattgat cagcttgtcg caaaaggaaa 2146501 gaaaggtgct aaagcggcaa agcatgtcat cactcacctt gatgaatatt tatcagcctg 2146561 tcagctgggc atcacagtcg cagctttagg actgggatgg cttggggaac cgactgtgca 2146621 aactctgctt cgaccgcttt ttcataaagc aggcttaaat gaatcgctta cccacctgct 2146681 ttcactcgtc atcgcatttt tagtggttac gtatttaaat gtcgttattg gggagctggc 2146741 gccaaagagt ttcgccattc aaaaagcaga aagcattacc ttgttgttcg ctaaaccgct 2146801 tatttggttt tataagatca tgtttccatt catttggctg ttgaaccact ctgcccgatt 2146861 gattacagga gtgtttgggc tgaagccggc atcagagcat gagctggctt atacagagga 2146921 agaacttcgg gtcctattgg ctgaaagcta taaaagcggc gagatcagaa aaagtgaatt 2146981 aaagtacatg aataatatct tcacctttga taaacgaatg gcaaaggaaa ttatggtgcc 2147041 gcgaaatgaa atggttagtt tgtcactaga tgaagactcc atttcaaatc ttcaggaaac 2147101 agtcaagcaa acaaaatata cacggtaccc ggttgtaaga gaggataaag ataacgtcat 2147161 tggcgtgatt aatatgaaag aagtgctgtt ttccatgctg acgaaagatt tttcaatcaa 2147221 gaagcatcaa attgaacctt tcgtacagcc cgttatccat gtaattgaga cgattcctat 2147281 ttataaacta ttgctgaaaa tgcaaaagga acgcactcat atggcgatcc tcatagatga 2147341 atatggcggg acgtccggtt tggtcactgt cgaggatatt atcgaagaaa ttgtaggaga 2147401 aatccgtgat gaatttgatg cggatgaagt gcctcatatc cgcgaacttg gaaaggatca 2147461 ttacttgtta aatgcaaaat tattaatcag cgatgttaac agcctgcttg gaaccgattt 2147521 atcagaggct gaagtagaca ccttgggcgg ctggtttttg acacaaaaca tagacgctga 2147581 gcctgaaagt gccatagaat atgatggcta ctcttttaag gtaaaagaca tcaacagcca 2147641 tcacatttta tttatagaag ttaaaaaagc tgaatagccc gtgaaaggct gttcagctgc 2147701 tatctttcaa gataaacatg gcaaaggcat caacactctt ttattttaaa ccctttattg 2147761 gccagggctt tagcaagact ttgctctgtt ttcacattcg aaaaatccag acccagcttc 2147821 acgacagttt gggcaatttc cggcctgatt cctgaaataa tagtctcaat gccgagcaat 2147881 ttggtgctgt caatcacttt aaaaatttga taggctacca tggtatcaac gataggaacg 2147941 cccgaaatat ctaaaaataa atacgagagc tttaacgctg agcactgctc cagcacagac 2148001 tccaaaatcg tcctcgctct gtgcgtatca atttcaccga caagcggaag aatcccaatt 2148061 ccatcagtaa tcggcataat cggcgcactc aattcattaa tcatttcttt ttgcgcgttt 2148121 aattgtatca tggtcacctg gtgatattct tccgtaaaca cttcgatgat ctcatcaatg 2148181 ttttgattca agatccggct ccactcataa aattcctgaa tgctgatgtc ttgagaagaa 2148241 gcttcgctga atttatgaat ccattcaaac atgatgtgcc tgaaagtgtt aaactggccg 2148301 acactttgtg taaccgtcac ttcatgaacg gcacggtctc tggcgcattg aagagaccac 2148361 cggttgagct catcctctac gtcttctttt ctaagggatt ttgctacgat ggtcaccaat 2148421 aattcatgct ggtcttttaa cttttgttct agtttttgct gatctttcgc tgaatacagc 2148481 cagctgccgt ttgacgtaca aacttccagc cattgttgcg taatatcttt tttgtgctct 2148541 gttaagtgct gatcaagagc tatcatctta atgagttacc tcctgttttt gaaaaatgta 2148601 cgctatatat gtataacgcg tctgccttta cacatactat gtttagattc aatgggctat 2148661 agccaagcgg taaggcaatg gactttgact ccgtgatcgt tggttcgaat ccagctagcc 2148721 cagtttctga acaggtgaaa aaccgaagat aagctgattc gtataaatca gcggatcttc 2148781 ggtttttcat catgcagatt gatgaaccgt tttcttcttc gataacttca acagttctcc 2148841 cgggttataa ccaatcacca gctttttgtt gtctactaga atcgggcgtc gcaaaagctt 2148901 cggcttctcg attaaaagtt ccagcacctc atttaccgtc atttcttcaa tgtttaaatt 2148961 taaatttttg aaagtctggc ttcttgtcgc caaaatttca tcaattcctt ctgtcgttaa 2149021 cgataaaatg tactttaatt cttctcttgt cggggtttct ctgaataagt gccgttcgtt 2149081 aaattcaatt tgatgtgctt taagccaatg ttttgttttt cggcatgacg tgcagcttgg 2149141 atatgagtaa aaagttaatt gttgttccat tcgttttttc ctcctcagtt aaccatctct 2149201 ttgtagaata actacccgga tcatttttca tttaaaccat ttacagaact tttttcggat 2149261 tattttttaa aaaacattca tacaatagaa aacacaatca aagggacaaa ttccatttgt 2149321 atattaataa tgaaaatgtt tacatttcta ggtgtgatct attataataa cagtcagagg 2149381 gactctcggg aggggataaa aatgaatcgc atgttccggg tgttaggatt ttggacggga 2149441 atttttgcag tcatgtttta tttaggtgat atgaaagatg cttccctttt attttttgga 2149501 cagacgatct tatttgtgtt tctatcgtat ttgaacttaa ccgaacgcat gtatatttat 2149561 atttttggcg cttatttaac aattttcttc gccggcttta catattactc aatttttatt 2149621 atggtgcccg gcggcggagg ccattaaatg cagaaagaga caaaccttat cggtttgtct 2149681 ctttttttac aatgaaaacc catttaaaaa cggattttga tcctgctcag tcagtacgtc 2149741 tgtttcaggt ccatggccgc ttaacaccag cgtgtgttcc ggaagcgtaa gcagtttttc 2149801 atgaatggac gtcagcagcg tctcttgatt gccgcctatt aaatccgtac gtcctatacc 2149861 gccttggaac aagacatctc cggaaatgac caagtctgca tctttcacgt agtaagacac 2149921 actgcctggt gaatgtcccg gcgtaaataa tgtttccaaa tgaaacggcc cgatattcaa 2149981 ctcaccgtcg ccttcaatta gatgatctgc aggcttagct gtgacttcta tccctcgcag 2150041 catgccggag ccgtttaaag aagcgtccgc aagccaattt ttttcatttt gatgcaggta 2150101 aacagggata tcccattttt ctctcacttc atcaagcgcc ccaatatggt caaaatgggc 2150161 atgtgtaagc aaaatggcta aaggcgtcag ccctttttct tttatgtatt gattgatttt 2150221 atgtccctcg ccgcccggat caaaaatcag acattgatca tcactgatga gaaaatatgc 2150281 gttcgcttga atcggcccta ctggcattcg tctccatttc actattatca cctctttctt 2150341 ttttatgctc ttattatgag ggtttttgaa aaaagattca aacaatcgca atgaaaacgc 2150401 tatcgacaaa cctataaaaa acaggtagaa taaaactgga aagaattgca ggtttttcaa 2150461 tgtaaagggg gctgtgttat gttacttgtc gtgattttcg gccttgtcgc tcttttcgct 2150521 ttatggggag tcttgcgttc tgttagaaat aaaaatatac tcgggttttt attagccggt 2150581 gccaccttat ttgtctttgg atggtttacc gtgatgaccg taataaacag cgggtatcca 2150641 accgcacatt aaaacctgta tccgatcgga tacaggttta tttttatggc tgtaaatgtt 2150701 tattgacact ttctattttg ctctcaagcg tcgttttttt gtcacgcctg tcatcgatac 2150761 ggatattcgt tgccactctg tgcaatcctt tttgaaatgg cgcttcgtga attgcctgaa 2150821 taactgcaaa aaggtcactg agttctccct cgatcagcgt attcatcggt gtcagctgat 2150881 atttgatttt cccttctgct tgatatcctt ctaatatctt ttgcacatcg gctacgtaag 2150941 cactgacact gggtgtttcc gtaccgattg ggataatggt tacatctgcg atagccatcg 2151001 ttattccatc tccttttgat caatgatgag ttgcttcgtt tcatgtgatt tcaataaaat 2151061 aatttgctca aaatgaaagc cgtataacgc atatttcccg ttcggagata tttgaatcgg 2151121 ctccatttcc cgcagagaca caagatcttt tgtctctccc gatgctacat tgattgctgc 2151181 gagcttatat gcatcgccgc tttgtttgaa tgtataaaac aggcctcctg cttcatcata 2151241 gtcatactcc attggagcca aacttgtata tttcgcttgg agcggccatt tcgctgtaac 2151301 aggtgatgtt gattgcggcg ttttaaactg atacgtccct tttcctccgg aagctgattt 2151361 gacagtaaaa ctcatttgat ggaaagaatc gaagaataga acgttatcct caagcttctg 2151421 ttccgtctta gaagctgtat cgaacgtata taaaggccct gttttatcgt ctctaccctc 2151481 ttttacataa tcaaatgtat ttttggatgt ccaatgaatg aacggaacct gtactgggct 2151541 taagaaagat tcgtcttttt tagcattcac ctgatatgta tggaaatccc agttttcatt 2151601 gaattccgtc accatcattt gataaggatc atactgattc caagcagctt caagctcata 2151661 cgtttcgtaa tctttttcgt aaagcgtctc tccttctgca ttaagcaaaa ccactgccgt 2151721 cttttggcta tgtgtgattt gcagcagaat catctgctcc ctcgcattga tttgaacatc 2151781 aacgatttga ccatccgttt gatagagctt tttcgctttg cctgtaaaga tgcggtacgc 2151841 aaaaagctct gttttcgtcg gattagacgc agtatataat attgtgctgt tattcagcca 2151901 gccttccgcc ccatccgctt tttccgcgga aagcggtatg atgtcttttt tctcatcttt 2151961 tgccgccgat gcctgttttt gctgctgatg agatggttcg catgccgata aactaaacag 2152021 caataccgcc agcagaataa aacaaactga tctcatcagc attcccctcc gatcatcttt 2152081 attctctcat atttgcttcg gcagaaaaaa gaaaaagttt cagttactca tgaaaaaata 2152141 acgccctcca caagataccg cttgtggcgt tatatatgtg tgaaaactgc tgaaacggca 2152201 aaggattttg gccttttcca agttccaccg tatacccttc cttaaaataa tggtgaataa 2152261 accaatcacg aaatccagca tagctgtcta tatcccttac tcccttataa atgttcccgc 2152321 ttaactcctc aaactccttt atgacggcag cagattcctc aggctcaagg cctttatagc 2152381 cccaataaat ttcttctcct tgagtatgaa gagccagcag tctgtcaggc ggattctccg 2152441 tgatcagccg gtacatcgca atagattccg gctccgtaag cggagagatt cccggaaaat 2152501 cgcggtagct gggtgctgtc ggttttcggt atttttcaat ttcccataat gatggaaatt 2152561 gtttatttaa atcaaccccg tttatattcg ccttccattc attaaaattt ggacgatgtt 2152621 catttagcct ttcgagttca tctcttctgg ctcccatgac ttctgatccg tttaaaacaa 2152681 gatcaacgcc atccggattg acaagaggaa cgagggataa ggatgtgctg ttaaacagct 2152741 ttatgggaga aaagccaaag aaaggcgaat tgcagcataa tgacatacag tattccttaa 2152801 accattttag caggacagac gttgtaatcc actcattcgc atgaaatgac gcgttcatat 2152861 ggaccttttt tacggcatgc tccccaccag ccttcagctc ccagataggc ctgccgagta 2152921 cagaacggcc aatttcccgg catgagacaa acggaaaaac atcaataatc ttctttattt 2152981 ccttttcaac agctgaatca tcatagattt tctcttgctc aatccagcta tctgaaagtt 2153041 tcagctgccg aggctgtaaa aagcgcttta tgtcctgaat ggtttgaagc tctttgccgc 2153101 tatgctcctc tatcacataa ccagggcaat acaattgatg tttttgtgcg gagcgatttg 2153161 cacttttaag caattcctcg tctatcttca gttctttcgc cacattggcc aaattgttct 2153221 tgatctcagg tttcaccgta ataaacgcca tcatcatccc ccttttttgt tactatatga 2153281 cagcgtattt aaaaaaagaa agcctcccgc tcacttcgat gcgggagaca ttgtgattat 2153341 gatgcctgat caagcatttg tttttctttc cgctttgacg aattgtccag ccttttctgg 2153401 tcataaaatc gcaacaaatc cccataaatg atttcatcag aaagtgatag ctcctgtttt 2153461 gctttatcag caaatgcttc acattgtttt gtctcttcta acggttttcc cgtctctttg 2153521 tcataacacg caccgtctgt ataaacaacc tgatctgtga taaagctccc gtcccggagc 2153581 accgtgaagt ccagtttttc gtctgaaagc agatcgttgc cgaattgaat ttgatctttc 2153641 gtatcaatcc ctaaaagatt catcagcgtc ggcctgatat caatctgccc gcctactgtt 2153701 tcaatggttt gcggcttttt atcagtaata cccggaatat gaatgaccag cggcactttt 2153761 tggagctgta cctcttcaaa tggggttatt tcttttccta aaaactgccc catcgcttca 2153821 ttatggtttt ctgatatacc ataatggtca ccatataata caataacaga gttgtcgtat 2153881 aacccgtctt ccttcagctt ttcgataaac cgtttcagcg cctcatcctg ataacgcact 2153941 gtcggaaaat atttatttag cgtctggctg tttgaatcat attcatcaat caattgatcc 2154001 tcttcatcaa gatcaaacgg gaagtggttc gtcagtgtaa tcagcctcga gtaaaacggc 2154061 tgaggcagat ttttcatcag ctctgaggac tgctcaaaaa attctttatc cttaagtccc 2154121 cagccgactg aattttcgtc agttacatca tacgagttaa tatcaaaaaa cgaatcatat 2154181 ccaaatgagt cgtacattaa atcacgattc caaaagctct tattattagc gtggagcacc 2154241 gctgaatagt atccgctgtt tttcaaaatt tcaggagcgg ccatatattg attgcccgca 2154301 ttcgtaaaaa atacggcacc tcgtccaagc ggatacagtg aattgtccac gataaattca 2154361 gaatccgagg ttttcccctg gcctgtttgg tggtaaacat tattaaagtt gtagctctgt 2154421 tttataaagt cattcagaaa aggcgtgatt tcttctccat tcaatttttc attaatcacg 2154481 aagctttgcg tcgactctaa ggatacgaga atgacgttcc ttccttttgc agcgccgaat 2154541 aagcgtttgt tggcatcctt cgcattagcg gttacgtagt tttcaatctc cgtcaggctg 2154601 ttgctgtctg ccaacgctct ctgtgcggat tgctttgact gaagaacgcc atcgtaaata 2154661 tgaaaattaa acaggctaat gtttttaaca agcatttctc tgtcaaatga gcgtgtcaat 2154721 agctgaggtc tttccgcctc agacaagccc aggttgaaga aataaacaga agcaacgaac 2154781 aaaaaataag ccgcccgttc atttttcgtt gagggaatgt ccgattgaaa agctttttgc 2154841 cggatgtgaa gccatattaa aaccgcaata tctacagcta ataggaggtc tgtcggctca 2154901 agaagtgttc cgatgctgct tccgagatca cccatattgc tcgtttgaaa aagaacaggg 2154961 attgttaaga aatcattgta aaaacggtaa aaaaccatat ttgccagcaa tacaaacgtg 2155021 acaagacagc tcatcgcgat aatgtagcga tttctgtttt tgccttttaa aaacaggctg 2155081 aggccaaaaa taagcaacaa aaaactcaat gggttgataa acagaataaa ttcctgtgtt 2155141 agattgtcga ttttaatatg aaaactggtt ttgtaaacag catacgtttt cagccacatc 2155201 aataaaatgg caatcagcat aaatgaaatc ttcgaaaaaa acgtttttcg catttcaacc 2155261 tcctatgcag cacgctcaaa aaaatcagtc tattcccaac attctcatta acacatcaaa 2155321 ttaaatctta acctgagcac aacaaaaaat caatttcatt tacacaattt taacaatttt 2155381 gatgtttcag ccattcattt ttagcgatcc aagcgcctcc gataacgccg gcatcatttc 2155441 caagtgctgc gattgaaata tcagcagctt gggctgcccg cggaaacgcg catttgcgga 2155501 atgttttctc gacttttgat ctcagcagtt ctccggctct cgatacgccg ccgccaagaa 2155561 cgattttgga tggattaagc gagcttgcca aatttccgag caccaaacca agatgcttgg 2155621 ctacataatc aaccacctca agggcaattt catcattttc acccgccgct tcaaacacat 2155681 ctcgcgctga caattgttcg gttgctttta aacgtgtcgt ctttttagca tttgctattt 2155741 tttcttttgc aattcttaca attccggttg ctgacgcaat tgtttcgata cagcccgttt 2155801 tgccgcagtt gcagggcgct ccgccttcag ggatgctgca aatatggccg atttctccgc 2155861 cggcgccatt tataccatgt acaatttcac catttgcaat gatgccgccg ccaactcctg 2155921 tgccaagcgt cacgagaatg acgtcttttg cgccatcacc cgctcccttc cacatttccc 2155981 cgagcgcagc aatattcgcg tcattttcta taacagctgg gatgccggtt tctgtctcca 2156041 gatggttttt caaagcataa tttttccacc ctagatttac tgtttcataa accactcctg 2156101 ccgccatatc tacagggcct ggtgcaccca ttccgatgta tttgatgatg tgcttcggtt 2156161 tttgcagctc atccagcttg ctgtcgattg tttttgcaat tgtgacagta atcgtgtcgc 2156221 cggttttatc tgtcggaact tcccacttat gctgaatttc gccatattga ttaataaaag 2156281 cgagtttaat cgtcgttcct cccaggtcaa tgcccgcaaa ccatatctcg tccattttta 2156341 tcaccttagc ctttataaaa atctcttccg ttttttgttt gttccaattc ttttcgaagg 2156401 acagctgccg ctctggccca ctgctccttt tcaatcatgt ggttcatgta taattccttt 2156461 aattcatcca gcataaactc aatttcaagc tctctgtctc caaaataaac aatgtggcca 2156521 aacgttttta acagctgctg cacatcataa aatgtattca ttttcctcac catttcttga 2156581 acttaactat cataagcgta ttcataagga agcggtcagt caagaagaaa acgctgacaa 2156641 aaaagccagc ttcctttcca tattccacct ctatgattct ttattgtttt caatttgccg 2156701 ctgcagctcc ttgtagcgct gctccttcgg cttcagtttc acagccgtct ggatggcctt 2156761 ttctgcttgt gcaagctcat ttttttccgc atacaataac gctaaattgt aataggaagc 2156821 atggtcttta ggttcttttt tcactgctcg ttccaaaagg gaaaccgcct gatcatattc 2156881 gccgatttga atatcagaaa cagcaagaat tttcaaaaga tcggcagagg catctttttg 2156941 cgctgcttct ccgttcagca attctgttac ttcttcatac tttccttcct gatacagctc 2157001 gcttgcctgc tgaatcagcg ctgactcctg gtgtgaaggc gaatgcaatc cgtaatataa 2157061 aaatccaaca gccaaagcaa tcagcaaaac cgctgacaac aatctttttc caaaggctcc 2157121 ggctttaggc aaccccagtg ctgctgcagc gaaaaagccg ccaatcaagc cgccgatatg 2157181 tcctgaatta tcaatattcg aaaccgcaaa accaaagccc agattgatga taataatgac 2157241 aataatattg gttcctatag ttcttaaaaa catttttcga ttagacaaag caacatacag 2157301 taatgcacct aagcatccga atatggctcc tgatgcccct gccgaaggat acgggctgaa 2157361 cacaaaactc gcaatcgaac ccgtaatgcc agcagccaga taaatcagca aaaatctccc 2157421 cgatccatac atccgctcaa ccgctgtacc aaccgaccat aaagccagcg tattaaaagc 2157481 taaatgcgct atgccgatgt gaagcacgat cggtgtcaga agccgccacc attctccttg 2157541 tgcaatcagg ctgttttctt ttgctccaaa agccaccagt gtctccgtat tagtgctgcc 2157601 tccgtttatt tcgagcaaga aaaacatcag gatctgaagc gcaataaata aatatgtaaa 2157661 agtcggtttt ccgttttgaa aaaccgccgc ttcagttttt ctctgttctt cttgtttcag 2157721 cactagcgaa aggaagcgtt ctcgcgccat ttgcgcgttt tcaaacgaag cgtgttcctc 2157781 tgaacaatct tctgtacgaa atgatggaaa aaccgcttga agatcatctc gaagcatcgt 2157841 tcctctaacg atcgccggct caactgacac agttcccttc tcaaaagttt tttttgcaat 2157901 ctcttcccag tcatcaactg gggcttccgt tgaaaaaaac acgttcagca gcttcatcct 2157961 tcgtctgccc aattgatgtc tgactcgttc tactcgttcg gcctgctctt cgatgtctct 2158021 aaccatttct tgacggaaat caagatcgtg cttataaaga cgaactagat catgagagga 2158081 cttgtccggc gcttccagcc atatttcatc tgactcaccg gcttgtatga cgccataccc 2158141 gctattcacc aggtgcgccg caattttcca atatgtatac tccagcaaaa acatgtttac 2158201 cgctccaata gttttttttc attataacag ctggcgctcc gaaacgccta ctgaaagcaa 2158261 aaaatcccgt ttttcacggg attttagaaa gcttgctgta taaacttatt gcggataaat 2158321 ggaattctta aaaacaaatg gataaaagac cgcctgattc ctggctggct gagtacagta 2158381 ttcataagac ggtagcgatt ttgataaaac atgacggcag aaaccgcgaa aatggcatat 2158441 atcaaaagtt ttttcatgat atccctcctg ccaatagggt ttgttattct accttattta 2158501 ttctcgaata agggacagga aagttatgaa aaacaagaaa taatccgatc ctctgttatc 2158561 agcttatgta ccgggatgtc atgcggcaga cggggtacgt gcgcaaacaa ctggcactcc 2158621 aaaagcaaag agactgtctt cccttcatat tcacttaaat agcgatcata atagccgcct 2158681 ccaaagccga ccctaaaccc gttaacatca aaacaaacac ccggaacgat catcaagtca 2158741 atttgtgatg ggtttacttc ttttgttttt tcaattaccg gctcgagcag tccggcgtac 2158801 acggtttcga gctgatcatc agtctgatat gtgcgaaatt gcattttctt cgtgtccgga 2158861 tggcattttg ggatgcaaac ttgtttccct tcttcccaag cctgctcaat gacaggacgc 2158921 gtcggtatct ctaatcctct ggaaatagtg acggcaatgg tgccggcatt ttgccactcc 2158981 ggcagagaaa acaagtactt atacatacgt tccgtttttt gaagaatatc ttcatttgat 2159041 aaagcagaca gtgcctccag cgtctttttt cttaattgtg atttcatctc tcatccccct 2159101 cggaatagaa aaaaagccag aacctttttc aaagctctgg cttttttctt acacctcaaa 2159161 cagcaaagct gttattttgt ttcacggtgt aacgtagatt ttttatcacg tgggcaatat 2159221 tttttaaatt caacgcggtc tggattgttg cgtttgttct ttttagaaat atagttacgc 2159281 tcaccacatt cagtgcaagc caaagtaata ttaacgcgca ttattttccc tccaaactaa 2159341 aatcatttac ttattcagac ttatatataa taccactata atggacggaa tgctaggctg 2159401 tttttcaatg aattgctgaa ttattgaaga tacgctcata aagctgcaaa tatgatgaca 2159461 taatgagtcg ggggtggtgg agcttgaaca cttgttgtct gccagcttct tttatccggc 2159521 gggctttttc ccggtctttt aaaaaactgt ccagcagatc agcagcttcc tgtacgagcg 2159581 taaaatcagc gatgattgcc gttttgtcat gaaccgcata atcacaaaaa ccacctgact 2159641 gagaaacgac agtcagcaca ccttgttcca tgctttcttg cgcggcaagc ccaaacggtt 2159701 cataagaact agggaaaaca gccatttcac agtgagacag taacgttctg atatctttcc 2159761 tatttagaaa cggcagaaac atgacgcgat ccttcaggtt atatgccgca gccaatttct 2159821 catagcagga cagagacggc ccctccccag ccagcactag atagaggtca ggctgacgct 2159881 gcttcaagat ggcaaacacc tttaacagct gcgataatcc tttttccgga acaaaccttc 2159941 catatgaaaa gaggaatctt ctattcatgc ttctcgggat tttccccttc tcttcctcca 2160001 tagatgcagg gcttgggata acggttattt tcttatgtgc cgccttatca agagaccgct 2160061 tcataaatgt gcttaatacg atcaatgcat cagcggattc tataaggagc cgttcggtca 2160121 tgagcctgta tgggtgtggg gcttctcggc acaccttctt cctttcgctt tcaagaccgt 2160181 ggattgtcgc agcaagcgga aggccaagcc gttgtttcaa atactgggcg gcaggggcag 2160241 ttgtgtcatc atgggcatga atcagatcaa agcgtttatt gtgtgataac acatggcgaa 2160301 ccattgtaaa gttagcatca gctatgtaat cttcaaactt cgcatacgaa aacagctgcc 2160361 cgctcggagt aaaaaccgta atgttgatat gagggtttaa ataggaaatg aggcggttta 2160421 aatggacacc gagcccgctt ttcggctcat cgggatgttc gggtgaaagc atgagaatgt 2160481 tcaccgttct ttttcccctc tcccataaca ggtgtatgca gaaaattgcg cctcccacct 2160541 ggtgtgcgct tcttcaatct gaaaactgtt tatatgacga atcccatttt catcaagata 2160601 gatgtcgtct gtaccggcaa gcttgagaga gacattcatt gaattcacaa ttctgtattc 2160661 agcccgatat acagcatcac cagccgcctg tctaatcgtc cattctcctt tatcatacgt 2160721 tgtgcgtttt gtcctgacag cttcaatgtc ttttcttttg atgacaatgc gcaattcttt 2160781 tatcatatcc tgcgtttttt cgaaaaggac cgcttcagcc agccgcattg tttcttctga 2160841 gatttcccag cttacggtca aggtgtgagc gttttgaatg attatgtcga atgtgtccct 2160901 aaaaaaggaa agcttatgtc gtatattata gggaaatggg tgtttatcca tggactccta 2160961 acattctcct ttccaatcgt tcacttcgtg ttcctattaa accattacat gaagaagaag 2161021 cgaagaaaga tttctcgaca aaatctcgtt tttttcgcga attcctttag aaactattgg 2161081 ttttatggta taaaaaagaa ggataaaaaa agaatagaag gtgatgaaac gtggaaattg 2161141 ctattattgc gttgtttatc gtcagtatag cgctaattgc attctcatat tctcaaagag 2161201 acccgatgaa agatgtagaa caggagctcg aaacactgca gctttctgcg atgcaggaaa 2161261 tttacaagct caaaaagaaa atgacagtgc ttgaggaaga attactggaa acaaaccttg 2161321 tcattcgcaa atcaaagcag aacgacatca atcaaaaaat cgctaaacaa atactttcta 2161381 aatataataa cggtatgtca gctgaagcga ttgctaaagc tgaacatgta tcagtggaag 2161441 acgtgaatac gattatcaaa gataatgaga aggtgctcgt atgacaaaac ggggcattca 2161501 ggcatttgct ggcggcatca ttttagcgac agccgttctt gcagctgttt tttatctgac 2161561 tgacgaagac caggccgctg ctgtaaaaga taataaaaca gtaaccgaac aagacgtgaa 2161621 caattatctt gattctaaaa aattggtttc tgtcaaccgt gatgaatatc aaaaacttct 2161681 cgattcaaaa gagaaatcct taaacaatga cagcggctca gacacgaaat cagacaaagt 2161741 caaaacctac aagctcacca ttaaagacgg catgagcacg gcggatgtat ctgctattct 2161801 tgaaaaagag ggcattatct cttcggctca agactttaat gactatgtca ttgatgccgg 2161861 ctatcacaaa gaaattcgtg ccggcgagtt taaagtaaaa tcagacatga gtttcaaaaa 2161921 gatcgtaaaa acgttaacac gataaaaaaa caggctgact cagcctgttt ttttcatcca 2161981 aactttcctg aaatgtaatc gagcgttctt tggtccttcg ggttagagaa cattttattc 2162041 gtattgtcgc attcaacaag ctcgcccatg tagaaaaagg cggtttgatc agaaaccctt 2162101 gctgcctgct gcatgttatg cgtgacaatg acaattgtat atttatcttt cagctctaga 2162161 atgagttctt caatttttct cgttgagatt ggatctagtg cagatgtcgg ttcatccatc 2162221 agcaaaatat caggattggt cgcaagtgct ctggcgatgc aaagacgctg ctgctggccc 2162281 cctgacagcg aaagagcgga cgtatgcaat cgatccttca cctcatccca taacgccacg 2162341 tcttttaatg acttttccac aatttcctga agcttcttct tatttttggt gccgtggact 2162401 ctcggtccgt aagccacatt atcaaaaata gattgcggaa acggattccc tttttggaat 2162461 accatgccga tattttttcg caaatccacg atgtccactt tatcctttaa aatgttgctg 2162521 ccattatagt tcagctcacc tgcaagcttt acattcggcg tcatttgaat cattaaattc 2162581 aatgtcttga taaaggtcga tttcccgcat ccggatggtc cgataatcgc cgtaacctca 2162641 ttttcataaa tgctcaaatt gatatttttt aaagcatgat gctgcccata ccataagttc 2162701 attccattga cttgatatac ttcctgtttc attacagctt cggtagcaat actcattgcc 2162761 gccctcctat ccgaatttcc cgttaatata atcctctgtc ttttgctttt tcggactcgt 2162821 gaaaatctgt tcggtctgtc cgtattctac aagctcgccg tttaaaaaga atgccgtccg 2162881 gtcagaaacc cgcagagcct gctgcatatt gtgcgtgaca ataataattg agtattctct 2162941 tttcaatcct gtaattaatt cctctatttt tgcatttgaa atcggatcaa gcgctgaagc 2163001 tggttcatca agcagaagaa cagccggctt catcgcaagc gttctcgcga tgcataaacg 2163061 ctgctgctgg ccgccggata acgagagtgc ggatgaatgt aaacgatcct tcacctcatc 2163121 ccagagcgct gcttttgtta aactttcttc cacaatttca tctaaaacag ctttattccg 2163181 ctctccggca tatttcaatg catgtgtgat attcgcatag atcgatttcg gaaatggatt 2163241 tggtttttgg aaaaccattc cgatttctct tctcaagctg acaacgttaa tattgccgcc 2163301 caatatattt aatccctcat aaaggatttc accttccgct cttgcagatg gaattaaatc 2163361 gttcattcgg ttaatatttc tcaaaaaagt agattttccg catcccgacg gcccaattaa 2163421 agcagtcacc gcattttttt caatatccat gtttacatga tgaacggctt gtttatttcc 2163481 gtaataaatg gacagatctt tgacctcaag cacgtggttc tgcttcggaa caataacagc 2163541 tcgctcaggt ttttctttta ccatttgttc agacatgttt ttcgcctctt tccgttctaa 2163601 tttgccgtaa gctttttgta gatcatcgtg ccaagccatc tcgccgcgag attaaacaca 2163661 agaacagaaa tcaccagcac ggcagaacca ccgttggcaa tcgcttcagc atccggaatc 2163721 attccttgtg tattgacgtt ccaaatgtgg accgcaagtg tttcagcggg cctgaaaata 2163781 ttaagcggtg atgtttccga aaacgggttc cactccgtaa aattaagacg cggtgttgtc 2163841 aggcctgccg taaataataa tgcggccgct tccccgaaca cccttcctga cgctaaaatt 2163901 gctcctgtga tgatagaagg aatcgcactt ggaattaaaa ctgtttttac ggtatgccag 2163961 cgtgatacac ctaaagcgag agaggcttcc ttcagatctt tagggactga acggatcgcg 2164021 tcttctgtca cacgcaccat gacaggaagg ttaaaaacag ttaacgcaag cgctccgcct 2164081 atgatcgtat aaccccagcc tgttaagttg acaaacatca ataatccaaa catcccaatg 2164141 acaatagacg gaagagatga aagcacctct atacatgttc taatgaagtc agttactttg 2164201 ttattaggcg cgtattcagc catgaagact ccgccgccca caccgagcgg gattgtaatc 2164261 agcattgtaa taaacaaaat ataaaaggag ttaaacagct gatctcgtat gcctcctcca 2164321 gctgcaatgg cgctcgactt tgttgtaata aattgaaaac tgagctgaga aacaccgttt 2164381 ataataatat aggaaaacaa acctactaaa atggcagcga taatggctgc acacaaacca 2164441 aacattccgg tcgccagttt atctgttatt ttgcggttca ttacactttc ctcctagatg 2164501 acaagtagcg aataagcagg atgaacaaga atgacatcac cagaagcaca agccccattg 2164561 accacagcgt attgttttca acacttccgt atgtggtgtg gcccatattc agcgtgatga 2164621 tcgttgtcag cgttcccgca gtgtcaaacg ggctttccgg caatactctt gtatttccaa 2164681 tgaccatctg aacagccaaa gcttcaccga acgcccgagc catgcctaac acaacagctg 2164741 tcatcaatgt tggaaaagct gcaggcacaa gtacttttct gatcgtctgc catcttgtgg 2164801 caccaagcgc gtaagaaccc tctcgtaaac tcttcggaag agaagccatt gcatcagcag 2164861 aaatcgatgt gatcgtcggc agaatcatga cggaaaggac aatcgttccc gccaataaac 2164921 tgtgccctgt tccgctcgat ttgaactggg cgataaacgg caccaatact gtaagaccta 2164981 tgaatccata aacaacagat ggaataccga ctaaaagctc aatcaccggc tgcagcactt 2165041 tctttcccca attcggggca atctctgtca taaaaatcgc acctgcaatg ccaagcggcg 2165101 cagcgattag agcagaaaga atcgttactg caaatgagcc aaaaataaat ggcagcactc 2165161 cgtatttcgg atcactatct gtaggattcc aatttaagct cgttaagaat tcaattgggc 2165221 ttacaccatt tacaagaaaa gattgcagcc ccttaacgcc gaggaaaatg gtaatcgcaa 2165281 cagatgccgc aatcataatc agtgcacaag ctgtgactat cattcttccc cgaacttcat 2165341 ccaattgccg attttgccta gagctgatta agcgctcgct cacagacata ttttctctat 2165401 tgtttatcat tgttttacac tcctatgaat gtgttaagag gagaaacggt tgtccccgca 2165461 ctcctctttt tattaagatc agctttgctt cccgttggca tcacgtgtca ctttcatatc 2165521 agtaaccgga atgtagcctt ggtcagtaac aatgcttttt tgaatgtctt cactctttag 2165581 ataatcaaga aattctttag ctaaacctgt cgcttcacct tttgtataag aatgttgata 2165641 agcccagatc ggatactcgc cagttgctac atttttcgct tcaggtttaa caccgtcaat 2165701 agatagagca gttactttgt catctgttaa atatgagaat gcaagatatc caatcgctcc 2165761 cggagtatca gcaatgatct ttttcaccgt gttggaggaa tcttcagtaa tgccttctgc 2165821 aggctccgct ccgtcaagcg catatttcac aaatgtagca cgtgtgccgg aagaatcagg 2165881 gcggtttaca agtgtaatct tttggtcttt gccgccgagc tctttccagt ttttgatttt 2165941 gccagtgaag atttttttca attcatcttt tgaaatatcc tttacaccag catcagggtt 2166001 tacagctgct gccataccaa ctacagcgac ttgatgatcg acaagcgctt ttgcatcgat 2166061 gccttctttt tcttcagcaa aaacgtctga attcccgatc tgaacagctc cttcagagac 2166121 ttgagaaagc cctgttccag aaccgccagc ttgtacctgt atatcagcat cagggttttc 2166181 ttccataaat ttttccgcgg ctgcaagtac tagtggctgc attgccgatg aaccagaaat 2166241 ggttaaagaa cctgatgcct tttcttctcc ttttgcagaa tcgctattcg attttttact 2166301 ttctcctgca tttccgcatg cagctgcaat catcataaaa gcagccatca gaagcataag 2166361 caccaatttg ttttttttca tttcctgaat tccccctgcg tataatgtgt aatttgtcct 2166421 acacgtatag agtaaaggtt ctatgtaaaa agggtttgaa ccgaatgtta aggttttgta 2166481 aatcagtgcg tttttttgta taaaaaaaac gcccacatca tgtgagcgtt tttttttagt 2166541 tatcagaaga cgttgtgttt tctgcatttt cttcaatttt gtctttattc ttttgctgag 2166601 taccttcttt gtcctgcttc gatttcagct caaaatattt atccattact tccctgccga 2166661 tttcgtttgt aattgagtat ctttgattgt aatcaatgta agtccaagga actacgacag 2166721 aaatagcaat ctcaggattg tcagctggtg cataagccac aagcgtcgta ttataagtgt 2166781 ctgttcctgt ttttgattta tccggtccgt cgtaaaatga ttgggctgtt cctgtttttg 2166841 cagctggttt atacgatgct gaagccagtt gacctgcagc tgtcccttta gtggcaaccc 2166901 gtctaaaacc ggcttggacc tcttcaatat agctactctt catatcgact ttattcaata 2166961 cttcaggctg aacagaatca acgactgcgc cgatcccttt tttcgcattt gaatctctga 2167021 cttcctttac aagctgaggc ttcatgcggt agccaccatt tgctatggtg gagacatatt 2167081 gagccaattc cagcggtgta taagtatcat actgtccaat ggcgaaatca agcaagaaac 2167141 cagataatct gcttgtacct ttatatcccg tcatttcatt tggtagatca attcctgttt 2167201 ttactcctaa tccaaattga ctgaaataat ttctgaaggt atcaaatgca gaagtatcca 2167261 aaggcaatgc ttggtgaggt ttatattcac ctttaccaac tgcaattgct gttttaaaca 2167321 taaaaacgtt tgatgacttc tctaatgcag tttgaatacc aaccggccct aagttttgcc 2167381 aagatttttt ccctctttta tcctggccga tatacaatgg ttcatcctta aatacagtat 2167441 tcaaattaat cgctccagtt tgaagaccgg tcaaaacggt tgcacctttt acagctgatc 2167501 ccatagcgta ggatgaagtc atggctccta atgcataatc atcaaactta taggctccat 2167561 tttctcgttt aatctgcttc cctgccattg tcagcacttc gccgtttcta gggtccatca 2167621 tgacaacgaa tgcacgatcc aacaattcgg tactaggtct tgctttagca gctttaagtt 2167681 ttttctcaat aattttttcc actgattttt gcaaatcaat atcaattgtt agtacaagat 2167741 ctttcccggc tttgccttca gataccgttt ttgttcccgt gacattgcct tttgaatctg 2167801 tgatattttc gacttttgct ttttggccct gcagaaggct ttcatattgg tattccagat 2167861 agctttttcc gaccctgtca tttcggctgt agccaagcga cagataatgg tcgagcaagt 2167921 tggacggcaa tccttcatta gagctggaaa cacttccgag cactgagcga agaaggtttt 2167981 tataaggata ttcacgttcc caatcggacg tgacatcaac acctggcagt tcgtctaaat 2168041 gttcacttac cactgccatt tccttcgctg atacatcttc gtttttgata tattgagggg 2168101 tcaatgcata gcccgaatcc atctgtcttt tgatagcaag gatctgcata tctttatccg 2168161 tcaattcatt cagctgctta tcagtaatcc gttttagctg aagctggtat aaatcgtcat 2168221 cggatatttt tttgtcttca acctgctgtc tttctttaga gctaatgagc tttttcgctt 2168281 ctttcggtct agtcaaaatc caataatctt ttttatcccg ttctgttact ttttttgtat 2168341 cgactttgat catgtcagac agcttttttg cgatctttaa gcgctgttct tgcgtggtcg 2168401 atttagatct cgtgtatgtg attgcattta aagccttatt tgtcacaatg gcattaaagt 2168461 ttcgatcata aattttcccg cgtggtaccg ctgagctgac ttcactttgt tcctgcttat 2168521 tcgcttggtt tttgtaatca tcaccttgca cgatctgctt gatgcccagt tccacaataa 2168581 tccaggtaaa tataacaaag gcagctaaaa ataaaatatt cagccggatc ggaagcgact 2168641 tctttttctc tttatgattt tgcttttttg gtttatttct cctcataaca tcaccttttc 2168701 tatttacaga aagaaaagac actcaagtaa gagtgccagt tttcatttta aaggtttttt 2168761 cgactttttt ctacagataa cccctttttg gcaaaaaaat tatctctcgc cttttaaaag 2168821 ggtcggttct gttacccgtt tttggccgtc ttcttccatg gtttcatttt ccccttcttt 2168881 ctccttaaaa cgaatatcct tgacaaagta ataaatcaaa ggatgtccta tacccaatat 2168941 cgcaagtgac aaaggaattc ccacatcctc tttcagaagg gccacaatca ggagaaagca 2169001 caaaatggaa acaattctgc cggcgttcaa gaacatttct ctaagcacga tatattcaat 2169061 tcttgctttt ctggcatgcc tcgcgcgccc tatcacatca tatgtaagtg atacatatgg 2169121 cacaagcaac agaggatagc cgatggcaat aaaaacgccg tacgttaata atgtcgaaaa 2169181 gctcatatgg aacagaatca aaaacagcgc gccatacaaa ataagtccgc ccagcaaaat 2169241 cgattttttt ctcgcctttt tcttaatcag cctggatgca aagtagtagg caaagaagga 2169301 aacagctgaa ttgacaagac cgaatgtacc gagagcaagc tcgctgtttg tctcaataaa 2169361 tacaaacaca ctgattaaaa agacaaaaat cccttctctc aaaccctgaa aaaaatgcgc 2169421 attcgtgatt ctccgccaat tcatattgct atggcgctct ccaaatactt tgctcagcat 2169481 aaaacggccc tttgattctc tccgttttaa gaaaaagctc atcacgacag ccagggcaaa 2169541 taaactgagg gagagactga aaatcactgt ataacccgta ttattttcaa gccttgagat 2169601 cacgaatccg gctacaatcg ggccgatcat tcctgcagag gaagacagaa tgcccataaa 2169661 cccgttgaaa aagtctcgtg tatccggctc tgttatttca aaggtcagca cgttaaacgc 2169721 tagccaataa aagccatagc caactccgag caccgcgccg attagcacga ggcggctggc 2169781 cgccgtttct ccggctaaaa gcacacttaa ataaaaggca gctaaaaaaa tgacgccgaa 2169841 ccttaaaatg aataccctgt ctattttttt ggctaaccgt ccagccaaat aaaaggttat 2169901 cggctgcatt gtcacaatgg ataaattata tatcgccaaa tcaataaatt tccctgactg 2169961 cttccaaaga tacacattaa caaatgtatt ggacagtgca attcccagcg agtaaagccc 2170021 gccaatggtc agcagaaaga gtaagccttt gtttacgtct acatcgccta tcactttttt 2170081 tagtttgctc attactgact cccctttact atcccttagt ctgtctcact caaaccgaga 2170141 tatgtaaaaa gaagacataa aaaaacaagg tcccataatg aggaccttgt ttgtgccatt 2170201 attttgcttc gctgtataga cgagccactt cgtcccagtt tacaacattc cagaaagctg 2170261 aaatgtaatc aggacggcgg ttttgatagt taaggtagta agcatgctcc caaacgtcaa 2170321 gacctaagat aggcgttttg ccttctgaaa gcggagaatc ttggtttggc gtgcttgtga 2170381 tttcaagttt accgttgttc acaacaagcc atgcccagcc agaaccgaag cgtccagctg 2170441 ctgctgctgc gaattgctct ttgaatttgt caaagcttcc aaatacactg ttaatctctt 2170501 cagcaagcgc gccagtcggt tcgcctccgc cgtttggaga taaaagtgtc cagaataatt 2170561 tgtggttcgc gtgtccgccg ccgttgttgc ggactgcagt gcggatgttt tcaggaacag 2170621 aatcaagatc tgcaacaagc tcttcaactg atttgttggc aagagcagtg tttccttcaa 2170681 ccgctttgtt taaatttgtc acgtatgtgt tgtggtgttt cgtatggtga atagtcatag 2170741 tttccttgtc gatatgcggt tctaaagcat cgtacgcata aggtaattct ggaagttcgt 2170801 aagccatgat aattcctcct tagtatatat gtactgaaat gccgcttcac agcgagcctt 2170861 tcttcattca atgtaacaaa agaatgcttt gtaatcaatg aaaaagctca cgatttggct 2170921 catttcagcg gacatatttc actttaaccg ataatctgcc ccattaaacc tgccgccagc 2170981 atttcttata ggaccgtcca taaaaagtaa ccgatcatca aaagctgtat gatgcccttt 2171041 gcaataaccc ctgttaaaaa accaatgagt gagccgaggc caattttaaa cgctgacttt 2171101 aagtccttct gatggacgat aagttctgcg caaacagccc cgataaacgg ccccaatatg 2171161 atccctgcaa ccggaatgac aaaaggcccg attaataaac cgatcgtgct tccccatatg 2171221 gcagctttgc ttcctccgaa cctttttact ccaagcagat tcgacacgta atctgctgcg 2171281 aataatactg cggcaaaaac tgcctcaaca agccagaaca tataagaata cggactgaat 2171341 gaaaataaaa atccgtacaa tacaaatccg gcaacaataa atactacgct aggaataaca 2171401 ggatacacca gcccgataaa ggcaatgata aaaaccgctg caatcaacag ccaatacaac 2171461 atatccatag cttccatcct cccattttac tctgtcttct tcatgtcttc cttgtattca 2171521 cacgcatgca acgatacaat aagcaacata tattagttta gctaggaagt gaagatagtg 2171581 aatgtgtttc agcttttcat taaaagtaca tactctcccc gtgatattgc aaaaacaaga 2171641 tttcaaggaa tcggaaaagc gattctttat gtatttttgc tctctgtcct gtttgcaatc 2171701 cctaccgctt attatgtaag tacagggacc gtaaaatcaa tgaacggctt taaaactgtt 2171761 ttaaacaaag atttccctga tttcacaatt tcaaacggca aacttcaaac ggatgagaaa 2171821 aaagccacgg aatctcaggc aaatggtttc gttatcgtgt tcgatccgac agactcctat 2171881 ggcactgaac aaattgaagc aaagcaaaac gcaatcggca tccttcagaa caaatttgtt 2171941 ttggccattg acggacaagc ccaagaaatg tcttactcaa tgatgccgtc agagttacag 2172001 aaaaaagatg tcattgcagg tttaaaccaa aataaagcga tgattgtaac tgttctctca 2172061 gctcttattt ttctcgtaac agcagcggga aaatttattg aagtatcgtt tttagcgctt 2172121 atcgggttaa tcattaagaa ttcgcagaaa aaacatttat cctatcatca gctctggaag 2172181 ctttctgctt attccatcac actttcaact gtattcttta caatcatgcg ggcactagaa 2172241 gcaaccgtac caagtgaatt tttgctgaac tggtttgtca attttgtcat cctgtttctc 2172301 gttttaaaag agattccgtc caaaaaagta attaataaaa gttaaattat atttattttt 2172361 atcctttaag tagagagtgt gaaagcattt gcattaactt tttacttaag ggatatttaa 2172421 taaaatgtat agagcttaaa cagatacatt tataaaaaaa gctctacaat tactcaagaa 2172481 caagctctgg acaataatat cagaagtagt aagatgtaac atgaaagaag ttcttaacag 2172541 catttgacat atgtttttaa caaaataaga ataatgttaa attttaacta atagactagt 2172601 taaaatcata tggcaaaata ttttgcatcc tttcacaaca tatttacata agatagttgc 2172661 tatttaaaaa gccaggtacc aatagggcac ctagctttca gaattaaatc atcaacaagt 2172721 tagaattatc ttctttcctt ctattctcat tattgaactg ttatcttttt tgtgggttta 2172781 tgtatacaaa tgcagctccc ttagctttcc ccttatatac tgataaacct actgcccaag 2172841 gtgttcctgt cggttttggt aatttactga agtaaaactt tttggttgga gttctacttg 2172901 aaaagtaccc tgaatattgc gggccaatgt ccccaccctc aactatagat acaccaaagc 2172961 tcttataatt tagtttaccg cattttccat ttgtttcggc gtaagcatca atagatgttg 2173021 cactcttagt atatgtataa gcatctgtaa taactcttat tttacaacca gaaataccac 2173081 ttaccggttg ccaaccactg cttgcagcct ctgctttttc tttaggtgca actaccaaag 2173141 ttaacattag tagcaaaatt aaaaacacag aaaattttcc ttgcttcatt ttgtagatcc 2173201 tcctttaaac tattacataa ttatcctaac agatccattg ttcattgtaa ataatggaat 2173261 acgagtttta tattataaaa gcctcttttt gatctaattt tgcactattt tctattttct 2173321 atctgaagtt aatgtttagt cgaagaaatc ctgtcaaaaa agcgcctgta taaaaaccga 2173381 gcattcgcag tctcttttct tttgtcatga atcgaaatgg acaagcatac tatggtataa 2173441 aatttcgtat gcgggaggaa aagcgatgaa gcgtctcacc ttagtatgca gcattgtttt 2173501 tatacttttt attctttttt atgaccttaa aattggaacc atacccattc aggacctccc 2173561 tgtctatgaa gcatcagcaa aaacggctgt acaagaaccg gcttataaaa cggtgaaggt 2173621 aaagccgggt gatacggtta tgtcgatagt cggatcagca ggttctccgg atgacattgt 2173681 aaaggatttt gaagcactga atccaaatgt gaaagctaac gccattcaag ccggaacagc 2173741 gtataaattc ccggtctacc cttaatttaa cgttaatttc ttgtcagttc ggcgaagaca 2173801 ctgttacaat gtaatttgta aaataaattc acataaacca tactagaatt gttatatcta 2173861 gaagcggcaa ctacaattaa ggagcgattg caagtgagtg aaatcacaca tcgtacaaaa 2173921 acgcgtcccg tcaaagtggg acctttaaca ataggcggca acaatgaagt tgtcatccaa 2173981 agcatgacaa caacaaaaac acatgatgta gaagcaacgg ttgcggaaat taaccgtttg 2174041 gctgaagccg gatgccaaat cgttcgggta gcatgtccgg atgaacgggc ggcaaacgcc 2174101 attgcggata ttaaaaagcg catttccatt cctctcgttg ttgacataca tttcgattat 2174161 aaacttgcgt tgaaagccat tgaaggcggc gcagataaaa tccgaatcaa ccccggcaat 2174221 atcggccggc gcgaaaaagt tgaagcggtt gttaaagcgg ccaaagacaa aggcattccg 2174281 atcagaatcg gagtaaacgc cggttcattg gaaaaacgga ttttagaaaa atacggttat 2174341 ccgactgccg atggaatggt agaaagcgca cttcatcaca ttaaaattct tgaggatctt 2174401 gattttcacg atattattgt cagcatgaag gcctctgacg tgaaccttgc aatcgaggct 2174461 tatgaaaaag cagcgaaagc gtttgactac ccgcttcacc tcgggatcac cgagtcagga 2174521 acactgtttg ccggcacagt aaagagcgca gcaggactcg gcgccatttt aagcaaaggc 2174581 atcgggaaca ccatgcgcat ttcactaagc gcagaccctg tagaagaggt aaaagtagca 2174641 agggagcttc tgaaatcttt cggcttagcc tccaatgctg ccacgctcat ctcatgcccg 2174701 acttgcggcc gtattgagat tgatctaatc agcattgcca atgaagtgga agagtatatt 2174761 tctaagataa aagcgccgat taaagttgct gttctcggct gcgctgtaaa cggacctggt 2174821 gaagcgagag aagctgatat cggaatcgcc ggcgcacgcg gtgaagggct gctgttccgg 2174881 aaagggaaaa ttgtccgtaa ggttccagag gaaacgatgg tagaagaact caaaaaagaa 2174941 attgacattc ttgctgagga acactacgca aaacttgaag ctgaaaaagc aaaattaaaa 2175001 gaagaaacac aaaaagcttg acgggaaccc gtcaagcttt tttgtgttag aaaaatggaa 2175061 taataaatat tccaagcact aatgaaacga caccgatacc cattgcccag gctccaaggc 2175121 cttgagcacc tcttcttctt gcgatatagc cgacaataat accagcagct cccaataaaa 2175181 caggcagtac aaacaatgaa atgatggaca aggctaaagc gatgtaccct attccccgtc 2175241 cttcattgac attgccgccg ctgcgatcat tgtcttggtc attgctgcgg tcagcagcac 2175301 gataaggctc tgcgatttca gcagctgttt cctcaaaaaa accgtcattg tcgcgggtaa 2175361 tatttgtccc ttcagatcca tgatcaacat agtaactgtt gttatcacgc ttttcgtaat 2175421 cgtttgccac cttcaattcc cccttctgtt ttattaaagg agcttttata gtttgatcca 2175481 ttttgcctga ttcatgtttg ctaaactttt ctgttaatgt caattgttta tgttacactt 2175541 gaagggatga aactgaagga gtgtgggcat gttacgctta ggaatagata ttgacggcac 2175601 aatcacggct caggatacat tcgtccctta tttgaaccgt tcgtttaatc tttccatttc 2175661 attaaacgat atgacggatt atgatttaac aaagctgtta aacattaccc aggaagaatt 2175721 ttgggattgg atgaatcaaa atgaagcgat catatataag gaagcattgc ttgcacagca 2175781 tgcgaaacag tctctcgatc ttctcaaaga ggagcacaag cttatttata ttacagcgag 2175841 acggactcat ttaactgata ttacttatga atggtttgac agacaaaaca ttcattatga 2175901 ccacatcgaa cttgttgggg gtcatcacaa agttgaagcg gtcaagaatc ataacatcga 2175961 cctgtttttt gaggatcatc acgggaacgc catgatgatt gcgaaagaag ccgggatacc 2176021 ggtgattttg ttcaattccc cttataatca gcttccgatt gattcaaaca tcatcagagt 2176081 aaacaactgg ctagaagccg ttcaatggat gaacaacaac aagcatcact taatacgcgt 2176141 caataactga aaaaggagcc caaaccgggc ccctttttca tatatacgca ttttacgcag 2176201 tagtgttttc ttggttttcc gctgtacaat cagggcatgt gccataaatc tcaaatttat 2176261 gcccgctgac ctgatagcca tccaaatcat cacaaagctt gtccatcgga catgattcaa 2176321 tttcctttgt tttgccgcag gcaagacaaa taaaatgatg gtggtgatgg gtgaatgaac 2176381 acttaaatcg gaagagcttt tcaccggaca gctcagttgt ttccaaaatc ccaagttctt 2176441 catataaaga aagatttctg tagattgtat caaagcttaa gcctggataa tcatcattca 2176501 gtgcagacag tacgttttta gcggtaagat atctgtctga atcagcaaaa agctgcagca 2176561 tatcctcccg tttgtttgta tatttatatc cgttttcttt taataggttc agcgcttctt 2176621 ggacgttcat gaagggtccc ccttttcgct ttgcttaaga acgtatcaca tgtatgaaaa 2176681 agaaaatggc agctgtctgt ccagcaagcc attttcttta ctgcagataa aattataccc 2176741 ataaaatgaa taaaagtaaa tgaaagccta gtggattgcg tttttgaatt ttccgcctct 2176801 cgtttcatga gtattcataa ttgttatgaa tgcattttga tcaacttcaa acacgatcga 2176861 tttgagcttt gtcacttcca gccttgtgac aaccgcgtaa attacgtctt tttcttcgtc 2176921 cgtatacccg cctttcccct tcagcttcgt tgtgccccga ccgagacggt gcaaaatcgc 2176981 gtcggaaatc tcatcatact gctcagacac aataatgaca gcttttgttt catcaagccc 2177041 ttggatcacg gcatcaatcg ttttcatcgc aatataataa gtcatgaatg agtacatcgc 2177101 ttgctcagga ccgaacacaa aaactgccca aatgaaaatg aacacattga tgaacataac 2177161 gaactcacct acagaaaacg ggagtttttt ggtcagcaaa ataccgagaa tttctgtacc 2177221 atccattgaa cctccatttc gaataacaag cccgacgcca aagccgagta aaagacctcc 2177281 gaacacagta gccaaaatag gctgggttgt aatggcttct acatggtgaa gtgaggattc 2177341 aataacggca agcccgacaa tccctataaa cgtagagact agaaaggtct taccgatata 2177401 tttatatccg aagatcataa aaggaatatt taatatgaca acgaaaaaag cgaaattcag 2177461 aaaggggttt gacataaaga ggtggtctaa aataagagat acaccgataa tcccgccatc 2177521 aataaaatca ttggggatta aaaataattc aatacttaca gccgcagatg cagctcctac 2177581 cagaatcata aagaccctga aaataaaatg ggtaaatgtt tctttcttat gttgttttgt 2177641 tggggtcata aaatctcctt tcctgcaata actattttaa atacattata aatctatttt 2177701 accattaaac actgacacat tttactgatt tgcccataca ttaagtctgg aggtggaatg 2177761 accgatgatt ttatttcaaa gaattatttt gcagcggctt aatcaggcta ctgctgatga 2177821 tttgctgaag tactcaaaac aatacggaat cagcttaaca agatcgcagg ccgttgaagt 2177881 agcgaacctg ttatacggga aaaatgtaaa catctttaat gagagtgaac gaatgcggct 2177941 gctgaaacaa gtagagacga ttacatcgaa agaaacagct caaacagtta atgaactatt 2178001 caaacaattt acaagctaaa aaatgggggt gttatccccc attttttatt gctgtaaaat 2178061 cttttcaagc aatgtatcat caaattgttt ttctttcagc atttcaatct caaaacggta 2178121 tggcggtttt ttgttctttt tatcttcacc gacgtatggt gtttcaagaa tttttggaat 2178181 gtcttttaac tgctcatggt gaacaacata ttgcagtgcg tcaaaaccta tttcaccaaa 2178241 gccaatattt tcatggcggt cttttctcgc acctttgaca tttttgctgt cattgatatg 2178301 aagcacttta atacggtcaa tgccaatgat tttatcgaac tcatttagca ctccgtcaaa 2178361 gtcttcgaca atgttatacc cggcatcatg tgtatggcac gtgtcaaagc acactgacag 2178421 ctgctcattg tgtgtaacgc cttcgataat ctgcgcaagc tcctcaaagc ttctgccgca 2178481 ttctgatcct tttccagcca ttgtttctaa tgcaatctgg acattttgat tcggatcaat 2178541 cacttcattt aagccttcaa taattttttt gatgccggct tcagctcctg cccctacgtg 2178601 agcgccagga tgaaggacaa tttgcttcgc tccgatggcc gctgtccgtt caatttctga 2178661 acgaagaaaa tcaacaccca gctcaaaagt ggacggattt gtcgtgttgc caatattaat 2178721 aatataaggc gcgtgtacga taatctcgtc aatgccgttt tcttgcatat gtgcccggcc 2178781 tgcttctata tttaagtctt caattttctt tcggcgcgta ttttgcggtg cgcctgtata 2178841 gatcataaac gtattcgccc cataagagac tgcttcctgg cttgcagcca gaagcatatg 2178901 ttttccgctc atagagacgt gtgagcctat tctcagcaac aggttcccct actttctttt 2178961 cttagattgg tttcttctct gttttttctt gattttctcc atctcatagc tcattttctt 2179021 tttataccca ggcttaacct tcttcggctt tttcacgaga cgatgagcaa tttcatccgc 2179081 ttcattcggc gtttttttac gttttttgcg gcgctgacgg tcatcgcctt ttttccattc 2179141 gcccttttca agctctaagt actcaaattc gatgcccatt ttttcaagtc ttactaatgc 2179201 atcctcatca gtaagctcat aaatggtcat cgcttgtcct gatgagccgg cacgagccgt 2179261 tctgcccaca cggtgaacat agaaatcgag atcatccggc agctcatagt tgataacatg 2179321 gctgacacct ttaatatcaa tacctcttgc ggcaaggtca gttgcaatga tatatgtgaa 2179381 ttccaaatca ttgatctgct tcatgacttt tttccgctca cgtggtgtta atccgccgtg 2179441 cagcaagccg attttcatgc ctttgccagt cagatactgg gcaatatggt cagccgtatt 2179501 tttcgtgttg gcaaacacaa tccccaggta tggattcaga tgcgacatga tgtcaaaaag 2179561 gagcttgtcc ttgtcacgat gtttcgaagg aatgaggata tgctcgattt tcgcagcagt 2179621 cacctgtttt ggctccacat gggcgtattt cggattttcc atgtatttct tcaagaatgg 2179681 tttcagcttt tccggtatgg tcgctgagaa cacaagcatt tgcagatcct caggcatgcg 2179741 ggaaccgatg taatctacat ctgcaaggaa tcccatgtcc agcattaaat ccgcttcatc 2179801 aataacaaga gattccgctt tatgaacact taacgcctgt tctttgatta agtcagcaat 2179861 ccgtccaggt gtaccgacaa caagatgcgg ctgtattttc aatttatcaa ttgatttttg 2179921 tttatcagtg cctccgataa aacatttcga gcgaatctga cttccttctt caccctgcgt 2179981 gattttaagc gcttcctgat aaatctggtt ggcaagctct cttgtcggag ccgtaatgac 2180041 tacctgaacg acatccttag caggatcgat tttgtttaat aaaggcagta aataagcgtg 2180101 agtctttcca gtacccgtct gagactggcc gatgacgctt tcttttttta acactgcagg 2180161 aatcagcctt ttctggatat cagtcggttc gtaaaaacca aggcgatgta ctgcatctat 2180221 aataaatggt ttcaattcat aaagttcaaa tttcgtttct ttcatttttc ccagctcctt 2180281 aaagcggcac attatgtgtc catcatcaca ttatacccga ttttgcttaa aaacaccacg 2180341 tttgcaaggc gtttgtttta ttcagttatg taaagcaaat accgcagccc atgcatattc 2180401 taatagcaga gagagctgaa aggaggtaca agtatgtttt caccgcagca gccaatgaga 2180461 aattacccac agcccggacc gccccgcccc atgccaaatc agcgaatgat gggcagaaga 2180521 ccgcctaata tgcgaggacc ttcatttgga gcacagcagc aaggttttca gcaagccgga 2180581 caatttcttc ctcaggcaaa tgccggagcg agaaatggtg caggtgcagg cggaggctta 2180641 aaaggaatgc tgtcaaggtt cctccccggc ggaggaggcg ctggcagcgc cggggttccc 2180701 ggaattccag gagcaggtgc agcagcgagc ggaggtgctg gcctgcaagg cattcaaaat 2180761 attgccaatc ctgcatcatt atccagtatg cttggaaatg tgcaaaaagt actcggcatg 2180821 gcgcagcaag tcacccctat gatccagcag tacggcccat tagtccgcaa tctgccagca 2180881 atgatgaagc tgtacagcca attaagtaaa agtgatgata ctgagacaga ggccaatgag 2180941 gaaagtgaaa aacaatccgt ttcagaagaa tcatcagaaa aagaaaaaga gactgaaaca 2181001 aaaacctcag atgggaacaa aaaatcaaaa ccaaaaagtt cttctctccc aaagaaatct 2181061 aaaacaactg acaataaaga acaagaatta aaaacatctg ccccgaagaa aaaggaagct 2181121 gcctctcctg ctccgaaaag aacatcaggc agttcaaaac cgagattata tatttaacat 2181181 tctttgatat cttaagtgag attggctata atgagatcag aagaatgcaa gaatagagcc 2181241 gtttgattac ggctttttat attgccttta ctcacttcag tattggagga caaccgaaaa 2181301 tggacgtaat taaaatttca ccgcgcggct attgctatgg tgttgttgat gctatggtca 2181361 ttgccaaaaa tgcgtcgcta gataaaagct tgccaagacc catctatata ctcgggatga 2181421 ttgttcataa taaacacgtc actgatgcgt ttgaagagga agggattttt acattggacg 2181481 gctctaaccg tctggacatc ttaaagcagg ttgacaaagg aactgtcatt ttcactgcgc 2181541 acggtgtttc tcccgaagtc agaagaatcg cagaagaaaa agggttagtc gcaattgatg 2181601 ctacatgtcc ggatgtgaca aaaactcata atctaatctt agagatgaaa gaaaaaggat 2181661 atcacgtgat ctatatcggc aaaaaagggc atccagagcc tgagggagcc gttggcgtag 2181721 cgccggagat cgttcactta gttgaaacag aagaagatgt aaagaacctt gatatccaat 2181781 ctgagaagtt aatcgtgacg aatcaaacaa caatgtctca atgggatgtt cacgacatta 2181841 tggagcttgt caaagaaaaa tatcctcatg tcgaatatca ccaagagatt tgcctcgcta 2181901 ctcaagtgcg gcaggaagct gtatcagagc aggcaaaaaa agcggactta acaatcgttg 2181961 tcggagaccc gaaaagcaac aattcaaata ggcttgctca agtgtcagag gaaatagccg 2182021 ggacaaaagc ataccggatc ggcgacttaa gcgaattgaa gctcgaatgg ctgaaaggcg 2182081 ttaataccgt tgcagttaca gcgggagctt caacaccgac gccgatcaca aaagaagtca 2182141 ttcgcttttt agagcagttt gatcacgaag atccatcaac ttggacaact gaacataata 2182201 taccgctcaa aaaaatactt ccaaaagtaa aagcaaaaaa ctgaggctgt aaaagcctca 2182261 gtttttttat agaaatgtaa atggatttgt atctgtttca gaaacaaaga tattcacgcc 2182321 aaacttttta tcattacaca ttgatgtaag ttttctcgtg acgccttctt tcatgatttt 2182381 ttccgcgtaa tggcccggat caaccacatt taggccaagc atcatcgcat catgggccac 2182441 atggaagtat aaatctcctg tgacgtaaac atcggctccc tttcgttttg catgatgaat 2182501 atacttgttt ccatctccgc caagaacagc tacttttttc accatgctgt cagcatcccc 2182561 aaccattctg acaccattga cgtcaagctt gtctttcaca aataaagcga attccttgag 2182621 cgtcatctca tttttaaggg ttccgacacg gccgagccct ttttcggcgg gagtctgttc 2182681 gacaggatag atatcgtaag cgacttcttc atatggatgg ctttttatca ttgcattgat 2182741 aacagccttt tcgacgcttt taggaaatac agtctcaagc cttacttcat gaacaagctc 2182801 aagctctccc acttcaccga taaaaggctt agctccgtcc aatggcttaa agctgccgat 2182861 tccttcagat gaaaacgcgc aatggctgta ttcaccgata tggccggccc ccgcatttcc 2182921 gagcgcggct ctgacctgct cttcatattc cttcggcacg taaactgcca gctttttcag 2182981 aggatccgta taagtaggtg ccagcacttc cgtctcactc agctctaatg cttcagcaag 2183041 caaatcattc acaccgccgt ccgcaacgtc taaatttgta tgagctgcat aaacagcaat 2183101 atcatgcttc aaacactttt caattaacct tccggcaggc tgatctgttg aaatatgctt 2183161 tagcgaccgg aaaattggtg gatggtgtgc aataatcaag tcaacctctt tttcaatcgc 2183221 ttcatcgata acgctctcta acacatcaag tgtaaccatc acatttttaa ttggtttgtt 2183281 taaggtgccg atttgcaggc cgattttatc tccttcaacc gcataggctt tcggggaaaa 2183341 ttgttcaaac agctggatga tctgctgccc atttacactt ttagccatga tcgattacct 2183401 cctttaacag ctccattcga tcggcgagct cctttaattt ttgtttgttt tgctctgtat 2183461 ccgccgcttg gctgatctgt tcataaatgc tttgagtgtg ctgaagctct tgtgtccact 2183521 ttttcaaaaa gacagcattt ttttcttttg ccaagaaagg gccaacgagc atcccggctg 2183581 ataaagaaat accgtcataa gccgcatccc tgtctcccgc ttctgccacc agcacctcat 2183641 agcactttcc gtcctcttca aggattacct catctatcag cgcatatctt tctttataaa 2183701 gccactccct gatatgaaca gcatgaatat tcggctgtaa aatgagccgt tccttccccg 2183761 ttaatttgtc tttgcccgct tctaaaatgt gagcgatcaa agccccgccc attccggcaa 2183821 tcgtaatggc atcagcttca ccttttttaa tcacttccag tccgtctccc tgccttacag 2183881 aaatgtgcga gtttaagcct gatttttcaa cctgccgctt tgcagacaaa aatgggccgt 2183941 ctgttatttc tccggcaatc gccccgctgg ctttatgatt cagcaccgca taacaaggaa 2184001 ggtaggcgtg gtcagagccg atatcggcca tcaccgctcc attcggtatg tactccgcta 2184061 ctgtttgcaa tcgtttagat aattttaatt cgttcacttg tcatcacaac ttttctcaat 2184121 cattttttcc tttactatca tataaaaaat cagcccggaa tccaagctga agcaaatgat 2184181 tttgaaatta tttcttttga tgcgggtctg cacgcagcag tcaaaaataa aaggctgtcg 2184241 agaacatctc ggcggcctgt gaatgtataa agagaaaaat agttctttta tttaattttt 2184301 gacacccact ctgccatatc atccagctta tcggccggaa caagaccgga aggcattcca 2184361 ttaccgcctt tttcgatctt tgttttaatt tcagcgacat ctttcttatc ccctacacct 2184421 tttaagctag gacccgaaac accttcataa ttttcaccgt ggcatgcgat gcagtttgcc 2184481 ttgtaaattt cttctggtga agcgtttgca tctttctttt cagcagattt gctttctcct 2184541 ccgctcgcaa tctcccgaga gtcatcaagt ccttttactg ataaaaagaa agttagacca 2184601 attcctaaaa cagcgatcag caaaaatgga ataagcgggt tccatttcat ttcccttccc 2184661 cctttttgat ccttccccct atgtaaacac ttctaattct aacttatttt tacaaaaagt 2184721 aaatggattg ctatacaaaa gttttttatt cacactttat acaaaattga atagaaacat 2184781 gcctaaatct ctaatatcct ttttattcta ttgtataatg tattgtatac gcttacaata 2184841 gaaaatatgg aattagattt tgaaattttt caccacaatg ttcatttgca aatgacatca 2184901 tttttcagta aaataaaggc atattatcca tatatctttt taaaaaaaga agaacggatc 2184961 ttcaagaccc gttccatctt attcaaggaa atctttcaaa cgtttacttc tgctaggatg 2185021 tcttagtttc cgcaacgctt tggcttcgat ttgtcgaata cgctctctcg ttactccaaa 2185081 tactttgccg acctcttcta atgttcttgt acggccgtca tcaagaccga atcgaagacg 2185141 caatacattt tcttcacgat cagttaacgt atcaagcaca tcttccagct gctctttcaa 2185201 tagctcgtat gcggcgtggt cagaaggtga agttgcttct tggtcttcaa tgaaatcacc 2185261 aaggtgcgag tcatcctctt caccgatcgg tgtttccaga gataccggct cttgagcaat 2185321 ctttaagatt tcgcgtactt tttcaggcgt taaatccata tcttccgcaa tttcttcagg 2185381 tgttggttct ctgcctaagt cttgcagtaa ttgacgctgc acacggatta atttattaat 2185441 ggtttcaacc atatgaacgg gaatccggat cgttctcgcc tgatcggcaa tggcgcgtgt 2185501 aatcgcctgt ctgatccacc acgtagcata cgtactgaat ttataacctt tgcgataatc 2185561 aaatttttca acggctttca tcaggcccat gtttccttcc tggatcagat caaggaacag 2185621 cataccgcgt ccgacatacc gttttgcgat actgacaaca agccgcaggt tcgcttcagc 2185681 caatctgcgt ttagattctt cgtcaccttc ttcaatcttt tgagcgtagg cgatttcttc 2185741 ttttgcagaa agaaggttaa cccgaccgat ttcctttaaa tacatacgaa ctgggtcatt 2185801 gattttaacg ccaggcggta cacttaggtc attaaggtca aattcttctt cggctttggc 2185861 aagctgctga atattaggat cttctgtttc ttcattctca ctaattaatt caacaccttg 2185921 ttcacctaaa aattcataat actcatccat ttggtctgat tcaatttcaa agctggacat 2185981 acgctcagca atttcttcat atgtcaaaac gccacgtttt ttaccagact ctgttaattg 2186041 ctcttttact tggtcgaatg ttaattctgt ctcgtgggtt tgtttatcag ccattatgga 2186101 tccctccttc caaagcttgc aacgaattct ataagcggta tgattcttat tcggtccatt 2186161 caggcgtttt ctatgtgaac tgcctttaac aatgtgcgaa taatgaaatg acaattcatg 2186221 atgaggttaa gcgatctatt tgctcctccg caaggaatca ttgccaataa atgctcctca 2186281 tcagttctcc agttatttta aagatcggtt caatgtaacg atttcttgag ccaaagaagc 2186341 agctcttaaa aaatcttttt gcctttctgc ttcggctctt tccgcctctt tttcttttat 2186401 cattgaccaa tttctttgat tcaacacttt ttttacataa tctgataact cggcttcgct 2186461 aagctcttga ttaacctgaa gcattaatat atcggacaag agctggctta tatgatcatc 2186521 cgtcaccctg gccatcagat gctgaggcgt cagctcggct ccctcttcat aaaaagcata 2186581 aagataagcg gctaatgccc ggtgctcatc aatattaaat tgaaacccta cccggtcaat 2186641 cacttttttg atgacgctcc gatctcgaag catgtgagcg agtaacagcc tttctgcatt 2186701 ttcatacgcc ggacgcaaac gtttttgcct tgcttttgtc gtcagatgcg ctcgccgcgt 2186761 tttagtttca ccgctattgt cagcaggttt gttttgcttg ctgaaaacag acagctgctc 2186821 agttaaagac tcctgtgaaa gcgaaaactc tgaagcaagc tgctttacat agacttcctg 2186881 ctctagagac cctgaaagcg tgctgatttc tttcagtacg tctttaatgt aagctaggcg 2186941 gtcgccttca tcggacaggt tctttccttt tcggaaatat tgcattttga acgccattac 2187001 ggtgacactt gcgtcaataa tgtcgttttt aaatttttcc ccgccgaatt ttttgatgta 2187061 atcatcaggg tccaatccgt caggaatcat tgcaactctg actttgcagc cttttttttg 2187121 cagaagctcc gaagctttta aggtggcttc ataaccggct ttatcagagt catagcaaag 2187181 aatgatttct tcgacgtttc ttctcaggat cttgacatga tcatctgtaa gagacgttcc 2187241 catcgtggct atgctttcct ttacatccga gcttacggcc gatatgacat cagcaaaccc 2187301 ttcaaataag actgctcttt cctgctttct gatatgaagg cgggccttat aaaaattgta 2187361 aagcagtttg cttttatgaa agagcggggt ttcaggactg ttcatatact taggctgctg 2187421 gctgccaaga gccctgcctg agaaagcaac aacagccccg tgatgatcat ggatcggaaa 2187481 catgacacgg tttctgaagc ggtcgaaata tccgcttccg tcttcgcgtc tgatcaggag 2187541 acccgctttt tccatttgcg cctcactaaa tcccctcttt acaaggaatt tcgtgataaa 2187601 gtcccaagaa tcaagagcat agccaatctg aaattcatta atcagctctt tcgtaaagcc 2187661 cctagaaagc agataatcca gtgcctcttg accttctttt gtatttatta acaaatgatg 2187721 gtaaaatttc ttcaggagct catgtgcctc agccattttt tgttctccag aagactctgg 2187781 ccgggctccg gaatggactg ttatatcatc tggaaaatca atttggtatt tgtcagcaag 2187841 gtgagaaacc gactcggcaa aagaatagcc ttccatctgc cttaaaaaag agaaaacatt 2187901 gccgcccgct ccgcagccaa agcaatgaaa aatctgtttg tcgggcgata cggaaaacga 2187961 aggtgtgctt tctccatgaa aaggacagag tccaaagtag tttcggcctt gcttctttaa 2188021 ttgaacataa tcacctatga cttcaacgat atctgccgac ttttgcacct gatccacaat 2188081 ttcatctggt atccgatttc ccatcttata acactccgtc gtacattatt cgatgcttta 2188141 gtgcaaaatc ccttcatcgt tcgacaggat tttttgcagc agtgtaataa atcgttctcg 2188201 atcttcttta ttcaattttt taggcccttt ggcatatacg ccttttcttc tttgtttgcc 2188261 ggaaaaatga cggccctcta gggcaaaatc aatcgtgtct tccttgtaaa gacgacctct 2188321 ttccgacata acagagacat ttctgttcaa cagcagagat gctaatccga tgtcctgcgt 2188381 cacaacaata tctcccggtt tcacgtgatt tgcgatatat aaatcagcag cttctttatg 2188441 aggatcaaca tacttccatt tttcttcatt gcttctggaa agctgataat gttcaaatga 2188501 agcgacaaaa agaacttgaa cttcatactc ggatgctgtt tgtaaaattt catcttttac 2188561 cggacaagca tcagcatcga caaaaatcgt cttttcttgt tcattaagaa gagtaattct 2188621 ccatccctcc attaaactcc tgcataaaag caagcaaaat cgcacatcct ttattattgt 2188681 ggatgtatat gaatttgtcg aaaaatttcc gggagaaatt cttgacatct tacccataat 2188741 agtttattcg tatcacacga tccttaaacc taaaattaat cattttatca caatttttta 2188801 ttataataca aacttcacaa agatgctatt gtttttcatt attccctttt ggcacagcca 2188861 aaaacccagg atagagcgtc ctgagttata tgttttttgt tttgagatga tggataatat 2188921 ttgctgtttc ctcaaccgct ttatttgaaa catcaacaac ctggcagccg atccgatcca 2188981 caatcttttc gaaatactcg agttcctctt tgattctgtt gatatttgca taaatcgctt 2189041 tatcattaag cccgagtgat tttaaacgtt cttttctgat atgattcagt ttatcagggc 2189101 taatctttaa accgatgcat tttttcggat caacgttaaa gagttcttcc ggcggatcaa 2189161 cctccggtac aatcggaaca ttggcaacct tcaggcgttt gtgtgcgaga tattgagaca 2189221 gcggtgtttt agacgttctt gacacgccga tcaaaacgat atcagctttt aaaatccctc 2189281 ttggatcacg tccatcatcg tatttaactg caaactcgat ggcctccact tttttgaaat 2189341 aatcttcatc aagctggcgc acccgccccg gttcgtattt cgctgttaaa ccgtaggctg 2189401 tttccatttt atcaatcaac gggccgataa tatcataata taaaacattt gctttttccg 2189461 cttcggctat caaatattct ctgatttccg gcaccacgag tgtaaaacag ataatgccgc 2189521 cgtctgcctt tgcaagtgaa atcacttcat tgatagtgcc tatatcttca acataaggaa 2189581 ttcttcttac atgagtatca tccgccgatc cgttaaattg gctgagtgct gcttttacta 2189641 ccaattcagc cgtttcaccg acggaatccg atacaacata gatgatgcgg ttattcatat 2189701 tatccccccg ttagtttgca atcttatagg atttcatttt cagataaact gacaagtatt 2189761 ttggtcatat ttgtttttgt cactctgccg atcacttcaa agcctttatc ggtgtctttg 2189821 atgacaggca gtgcatcaat ttgtttttct attaagtgct ttgcaatgtc catcacataa 2189881 tcctcgcgtc tgcacaccgt aatgttcggc atccttgtca tgatgatgtg aacagggacc 2189941 gatgtaagct cctgctggcc aatgctcgct ctgagcaagt cttttcgtga aagcaccccg 2190001 actaaaacag catcgcggtc caccacaaac agagtaccta catcttctaa aaacatggtg 2190061 caaatcgcat cgtacacaga aacgttttcg tgaatcacta cggggataga ttgaaagtct 2190121 ttcacctgaa gctttttgag tttatccgcc aaaagctgtg tgccggtttt tcccgtatag 2190181 aaataaccga ctctcgggcg cgcctcgagg aatcctgaca tggtgagtat ggctaaatcc 2190241 gggcgcaatg tcgccctggt taggttcagc ttttctgcaa tatgctcccc tgtaatcggc 2190301 ccgttttctt ttacaatctg caaaatatgt tcttgccgtt tatttagttc gatcgtactc 2190361 accacctttt cacttcatag ctatgtaaag aaataacaat ccatattata acgtaaatat 2190421 cttgtaatca aacaaaaaac ttataaatgg ggaaaagacg attaccgatc acacagcaac 2190481 cgccttttct ctctttattt tacaataagg gcattcatat tcgcaaagga cttgatctca 2190541 tccgccaagc ttaccatttg cgctaaacga tttgccttta atgactcatt atccgctata 2190601 accattgtat gatcgaagta agcatcgatc ggttctttta aggctgcaag tgaagcaagc 2190661 gccgcctcat aatctttttt gctgaagttt tcctgcagat tttgcttcgc tgtttggtag 2190721 gcatcaaaca gttttgcttc gtattcattt tcaaacagat caggctgaat gtctccgcgg 2190781 actccttttt tgctgataga gatcactcgg cctaacgctt cggctgtttc cttaaagcca 2190841 ggtgcaccaa gcttttgctc cagtacttgt gctttatgca gcgcagagta cggctcaagc 2190901 tcagagcttt ccagcacggc gtcaatgaca tcatgtctga tttgttcagc attcaagaca 2190961 tatttcaagc gctgagtgaa gaaatccagc agttcatttt ctttatcggt ttgaacgaaa 2191021 gtaagcagct cttcaaatga aattccccag ttgcggtcaa gaagaatcgc aacaataccg 2191081 cttgcttggc ggcgcagtcc gtaagggtcc tgggaaccgg tcggaattac gccgatagag 2191141 aagaatgaag cgattgtgtc aagcttatcc gccattgcta caacagctcc ggtgaaagta 2191201 gaaggcgttt ctccgcccgc tgatctaggc atataatgtt cattaactgc cgcagccaca 2191261 gcttcatctt cgccaagcat tctcgcatac ttttcgccca taattccttg aagttcaggg 2191321 aattcatata tcatatgcgt cacaaggtcg aatttagaaa tttcagcagc ccgcttcaca 2191381 tgttttaatg tatcttcatc agcctgaaga cgaacggcaa gtttctctgc gattgatgtg 2191441 actctcctaa ccttatcagc aagagaacca agctcttcat ggaaaacgat attttcaagc 2191501 ttcttcacat ttgcatcaat gtttagtttc tgatcttctt tgtagaagaa tgaagcatca 2191561 gataaacgtg cgcgcagcac tttttcattg cctcgggcca cattttcaat cgcgtggctg 2191621 ttgccgtttc ggactgtgat aaagtgaggc agcaggtcac cgtttttgtc tttgacaggg 2191681 aagtagcgct gatgctcttt cattgtcgtg acaagcactt cttcaggaat tgacagaaac 2191741 tcggattcaa atgaaccgta aagagctgtc gggtattcta ctaaatgatt cacttcatca 2191801 agaaggtctt cgtcaactgg aatgctccaa ttgttttcag cagccattgt ttccagctga 2191861 gattgaatca tttgctttcg gacgctagga tcagcaataa catgctgtcc tttgagctgc 2191921 tcttcataag ctgaaggtga ttcaattgac acttcatgtc cgaggaaacg gtgtccctgt 2191981 gttgtccgtc cagactcaac gtttgtgatc gaaaatggaa tgacatcctg tccaaataat 2192041 gcgacaatcc atttgatcgg tcggatataa cgcaaatctt catttcccca gcgcatgttt 2192101 ttcgggaaat gcaagcttgt aattaaaccg ctcaattctg gcagaagcga cttcgtttct 2192161 tggccggctt ggaatttttg cacgaataca tactctatgc cttttacttc tttgatgtac 2192221 aggtcttcca catttgcgcc ttggcctttt gaaaagccga ttgccgcttt tgtccagttc 2192281 ccgtccgcat caagggcaat ttttttcgca ggcccttttg cttcttcttt tatatcatcc 2192341 tgcttttctg cgacatcctt aacgaacaca gcaagacgtc tcggtgtatt gaagagtttc 2192401 acttcaccgt gagtaatatt tttttcttta agccagcctg tcagcttgtc gccaagctga 2192461 accatgcttt cattcaaaaa gcgcgccggc atttcctcta atccgatctc taaaagtaaa 2192521 tcctgtttac tcatgagaag aaccctcccc tttaagcatt gggaacccta gtttttctcg 2192581 ttcctcatag taggtttttg ctacttttct agctaaattc cgcactcttg cgatatagcc 2192641 cgtccgctcg gtaacagaga tcgcaccttt ggcatcaagc aggttgaaag tgtgcgagca 2192701 tttcagcaca tagtcatatg ctggatgaac aagtccgttg tccatttgct tgatcgcttc 2192761 tttttcatat gtgctgaaca attggaacag catatcgacg tctgatgttt caaacgtata 2192821 aacagaatgc tcatattcag ccatcatgaa taaatctttt actgtaaacc ctgacgtcca 2192881 ttccaagtca aacacgtttt ctttatcctg gatataagac gcgagacgct caattccata 2192941 cgtaatctct acagaaacgg gtttacactc taatcccccg acctgctgga aatacgtaaa 2193001 ttgtgttatt tccattccgt caagccaaac ttcccagcct agacccgcgc agcctaaaga 2193061 cggattctcc cagttgtctt caacaaagcg aatatcgtgc tcaagcggat caattccaag 2193121 agcacgcaag gaatccaaat acagctcttg aatgttatca ggtgacggtt taataatgac 2193181 ctggaactga tgatgctgat acagtctgtt cgggttctcc ccgtagcggc cgtctgccgg 2193241 acgtctggaa ggctctacat aagccacttt ccacggctca ggaccgatac tgcgcaaaaa 2193301 tgtatacggg ctcatcgtgc cggctccttt ttctacatcg taagcctgca taagcacaca 2193361 gccctgactg gaccaatgct tttgcaaggt tagaatcatg tcttgaatat tcatttcaag 2193421 cacctccact tttctttcat aagttgactg cggcagcaac caaaaaactc ccgtctctat 2193481 gcttgccagc cgcaaacata gggacgagag ttctcccgcg gttccaccct agttgctgag 2193541 aacaaaatcc cagcctcttt tttaaaattg ctcaagaatg cctttcgttg cgtgctcatc 2193601 cttagcttac accgccctaa ggtcgctttc atgaggtaaa cgcaagtact tctttctctc 2193661 actgcaacat attttataat aaatgatcat ataaaaagat ggaccaaatg tcaacttttg 2193721 ttttcaccca taagatgttt catgctttcc atttgatcta aaaagcgctt tgattttaaa 2193781 tacaatcccg aatattcttc gtaatataaa tcaatcactt gctttaattc agcttttgtt 2193841 tcctctttta aggacacatt gccgagtctc gacagatcaa aatagtaaaa gagccttaac 2193901 agccttgccg tttgcggttt aatcggtatc ctgtaaggat ctttttcaaa acagcggtgg 2193961 catataaaac cattatcacg aacagagaaa tgaaaggttc cgtcttggct tttacaatgt 2194021 acacaatgat tcagctcagg atacaggccc atgacaccga gcatcttcat ttgaacaatg 2194081 aaggtgataa catccggatc tgttccttca ttcaactgtt ttaatgattc taatatgaat 2194141 tcaaataaat aaggatttgg ctttttttct tctgtgcctc tgtcgactaa ctcagcaaca 2194201 taggcagcat atgctgttaa aaacaagtct tccctgatgc ctctcatgct gaggatcatt 2194261 tccccctgct gaagcgttcc gaggcccgat gttttttgca ttaagaaaga accatacaaa 2194321 aagggctggc tgactgctga taaacggctg ttcggttttt tggcgcctcg tgccataaca 2194381 cctatttttc cgtgttctct tgtcagtaat gttacgattt tattcgtctc tccgtaatca 2194441 tttgtgcgaa gaacgatccc ttcacatttt gtcagcattt ccgcaccttc ctcaagcagg 2194501 agcggccaag aggtttataa aattggataa tcaaatcggg ctagctcatc ttctagttct 2194561 tcgggtcttt ccatgttctc tttttccagt tctttaaaaa gaagatacgt atcaacattt 2194621 cctgtttgag aaaatacgtt ccaggtaaaa ttcaacacaa gaaacccacc tttctgtagt 2194681 taaactagct tacctaaact ccaaattctt acctttatct tgaccagatg tcctccattt 2194741 catgttaaac aaaatttgct aatgtatccc tgttcctgtg agataatgac acacacggga 2194801 agagattaat attcgtcctc tttaaagcca aaatcgcgaa gctgggacat tttattacgc 2194861 cagtctttct gcactttcac ccacaattca aggtagacac gggagcccaa cagtgcttca 2194921 atatccgctc tcgctctttt tccaacctct tttagaaggc ttcctttttt accgatcacg 2194981 atgcctttct gggaatcccg ctcgaccaca atcgttgccg ctacgtgcac agaaccgttg 2195041 tcctgccctt tgatggattc gatggccacc gcaatgctgt gcgggatttc ttctctcgtc 2195101 aaatgcagca ccttttccct gattaattca gaaatgataa atcgttcagg gtggtcagtt 2195161 acctggtcac tcggatagaa ttgcggccct tccggcaaat acgcttcgat ctgcgcgagc 2195221 aaggtttcga tgttatttcc ttctaaagca gaaatcggaa caatttcctt aaaaggataa 2195281 cgtttgcggt attcgtcaat tagcagaagc aattggtcgg gatgaatttt atcaattttg 2195341 tttacgatta agaatacagg cgtagacatc gtctgcaatt tctcaatgat gaattcgtcg 2195401 cccttcccgt agccttcctc agcattgatc ataaacaaga tcaaatcgac ttcttttaat 2195461 gtattttgcg ccactttcat cataaagtcc ccaagtttat gcttaggttt atgaatccct 2195521 ggtgtgtcaa taaaaatggt ttgtgatgtg cctgtcgtca gtactccttg caccttgttt 2195581 ctcgtcgttt ggggcttatc gctcatgatc gcgatttttt gtccaatgac tctgttcaaa 2195641 aatgtagatt ttcctacgtt tggtcttcca ataatggata caaatcctga tttaaagctt 2195701 tcgttcgtca tgtaaatcct ccgatgaaaa tgcgcctggc aataattctt ccacagtcat 2195761 ttcttttatt tgtccttgta aattagtcag tacgacaata acgtcttttg tgcaaagctc 2195821 agaaatcacc tgtcggcagg ctccgcacgg agatactggt ccaggggtgt cagccgcaac 2195881 ggccagcatc tgaaactctg tatccccttc agaaacagct ttaaataaag cggtacgctc 2195941 ggcgcaattg cacatgctgt atgccgcgtt ctcaatattg cagcctctgt acacttttcc 2196001 atccttggta agaagagcgg ctcctacttg gaatttggaa tacggcgcat atgccatatc 2196061 acgcgctttt aaagcttctg ttattaattc ttgtctgttc atgtgtacat tcctctctta 2196121 cctataatgg taccgctatc actttatatt ttacataatc gcgcgctttt tttcacgccc 2196181 atttctaaaa atgtaaaata aatgtaagaa ttttcagcca ttacagcttt ggcaaaaaaa 2196241 taagtaaacc aatgatacac gaaatcacgg caaaaacgca aacagccccg gcggcagcgt 2196301 ccttggccgc tttagcaaga gggtgatgtt tgtcagttat taaatcaacc gtatgttcaa 2196361 tggctgtatt taaaagttca agcgaaaaca taccacctat caaaaggaat ataatcatcc 2196421 actcaataat gctgagctct acaaggaagc cgcaaatgag aacagcgcag gcggctgcgg 2196481 catgaaattg gaaattccgc tccgtccgcg ctgtttccca tatgccccgg cctgcatgca 2196541 cgaagctttt gaagaatcga ttcagctcat ttctatgatc ttttgagtcc ataagcgtcc 2196601 agcaattcct tttgcttagt aaacatctcc tcttcttcct ctttcgtcat atggtcatat 2196661 cctaaaaggt gcagaaatcc gtgtacagct agaaatccga gctctctttt aaaagaatga 2196721 ttatactcct ctgcctgctc tcttgtgcga tcggcactga tgataatatc acctaaaacc 2196781 ggaggcattt cggcgcccac gatttcgatc tcgccttctc cctcttcttc aagagcaaat 2196841 gagatgacat ctgtcggagc atcctttccc cggtattctt tgttaatctg atgtatgtca 2196901 tcattggaaa caatcgtgac agaaacttca gcctgatcct gaacgccttc acgctcagcg 2196961 gcaaattgaa gcagattttc tacttctttg agcatctctt ctgagacgct tcccgtttca 2197021 tcaacgatat caatcagtaa actcatctat ttcaccttct tagtagcctc cggatattca 2197081 atccgggagt ggaaaattcc ttttaatgtt gcacagagcg tttttgcgat tgtatccagc 2197141 tctttaaatg tcaaatcgca ttcactgaac tgtccgtcct gaagcttatc ggatataata 2197201 ccccggacaa gcttttcaat tcgttcagga tttggattgt gcatggatct gacggccgct 2197261 tcaacactgt cggccactga tataattgcg gcttcctttg actgcggctt cggtcccgga 2197321 taacggaact cttcctctgt aatctggtcg cctttttcct tcgctttata gtaaaaaaac 2197381 tttaaaagcg aggttccatg atgctgctca gcaatatcga caagctcttt cggaaattta 2197441 tagcttctca gcatattcgc accgtctgtc gtatgcgaga taataatatt tttgctcaac 2197501 tgaggtgaca gcttgtcatg cggattgtca atattcattt ggttttcaat aaaatattgc 2197561 gggcgctttg tttttccgag atcgtgataa tatgcgccga ctcttgcaag caaaccatta 2197621 gccccaaccg cttcacaggc tgcctctgat aaattggcaa ccattacact gtgatgatat 2197681 gtacctggtg tttccgtcag tattttgcgc aatagcggat ggttaggatt agacagctcg 2197741 agcagcctca tggtggataa aatgccaaag cccgtctcaa aaaacggcat cagaccgatg 2197801 atcaatacag atgaagcaaa ccccgacaca acccccatga gcattaacgt gccgatttca 2197861 agacccgaca gcgcagtgtt ctggatcaat aataaggata gaacgacaac catattaata 2197921 aacgccacga aaagtccggt ctgcaaaatc tttgatcttg cattgtgttt tcctaaaaat 2197981 aatacacctg aaatgccgct gatcaaataa taaatcccta tgacataatt gaatgttcct 2198041 gtcacaccct gattaaacat catacttccg caaatcgcaa gaatgatact tcccaaaatg 2198101 gcaatgcgtt cattcatcag cagtttgatt aagatggcgc cggccgcaat ggggaccaga 2198161 tagccgatat tattatactc catcttctga aacaaactga caacctccat gatcacaagc 2198221 aaaagtgttg tgattatgga gaataacaga atggattggt ttttaaactt cagattttgt 2198281 ttctgttttt caaaataata tacaagtgtt gcaatgaaaa gtccgatcat aatcaatagc 2198341 ccgctgatcg gtttaaagag atttgagtta tttaataacc cggtcagctc aagtttcctg 2198401 tacacttccc gatcaatgag gtcattttct tccacgagca cttgcccctg tttgatttga 2198461 acctgctgga cattatctga ggcttcctgc cgttttgcct ctgttgcttt cggatcgaag 2198521 acgtaattcg gaataatagc aaaacgcccg atttctgtcg cggctcccaa gtatttagac 2198581 ggaatagaat tgctctttag ctctttttct accttatcct ttgcatcaga tagtttatcc 2198641 gaagggattt cactgctcat gaccgtattt accgcggtaa tgaccgtatc tctgacaaaa 2198701 gaaaagtctt cactgtctgc tttcagcaat gtcttgatgg aatcctccga tatagaatca 2198761 ttcacatctg atgtcaattt gtcctttaca gatttgacca ttgatttttc cgatggtgat 2198821 ttactgcctt cttccgatga ttttttcact tcactaatac tgtcgaatat tgatgacaca 2198881 aggtcaatcc gattgtctgt atattctttt tttaatgtat attgatcttc aaccgcgtcc 2198941 tcagcggctt gctttttttc ctctgtggct ttttgatctt ctacggttgc cggagcgtaa 2199001 atggtcttgt cgctgactga aaacaggtct aaatcaagtg tttccggctt aacatgtaca 2199061 aagagcaaag caaacataat ggcagccagc agaagataca gcagtacatg catggagcgg 2199121 gcatttttaa aactgctcca tttttttgag ctgcttttgg tcttagcctt ctttttcaac 2199181 acaagaacct cctcttgaaa catcaagccc ataagcaatc ataaaaatga cccgataacg 2199241 cgcgatcggg tcattcagca ttaattttgc ttatcgtatg cttcaataat tttcgcaaca 2199301 agcggatgtc tgaccacgtc tgtctggtct agctcaatca tagaaatgcc gtctattcct 2199361 ttcagcatct ccttcgctac tgcaagtccc gatttgacgc ctttcggcag atcaatttgg 2199421 ctaacgtcac ctgtaatgat cattttagag ccaaaaccca gtctcgtcaa aaacattttc 2199481 atttgagcag gcgtggtatt ctgtgcttca tcaagtataa cataagcatc atcgagcgtc 2199541 cgtcccctca tatatgcgag cggagcaatt tcaatgatgc ctctttccat cagacgttct 2199601 gtatgatctg ccccaagcac atcatggaga gcgtcataca gcgggcgcaa ataaggatct 2199661 actttttctt ttaggtcacc tgggagaaaa ccaaggcttt caccggcttc cacggcaggt 2199721 cttgttaaaa tgattttttt gatatgtccg ttttttaaag catggactgc ttttacgaca 2199781 gccaggtacg ttttcccggt tcccgccgga ccaatgccga atacaaggtc attccgcttc 2199841 atagcggcca cgtattcccg ctgtcccatt gtttttacac ggattgattt gccttttgcg 2199901 ttttttgtaa tttcttcttc atacatgctt tcaaagtatt caagttcatt cttctttgcc 2199961 attttgatgg cgtaaatcac atcacgttca gagatctcta tccccttgcg aattaaagcg 2200021 aggagcgatc ccagcagcct gtctgcaatc tgaaacgatt catcatcgcc tgaaacataa 2200081 atcgtctcgc cgcgcgtaat gatatttaaa ttcagatctt tctccatcaa tttcaaaaaa 2200141 gaatcttggt tcccgaagag tgaaagcgcc tcgtccgggt ttttcagttt ttgattcatc 2200201 gcaagtaaat gttctgtcat tcttcagtct ccctgacaat aggtgtggtt tgaacgatat 2200261 cttctataac ttggtagaga ataatcaact ttactttacc attctcaaca gtctggtgca 2200321 aaactttttc acttttcacc tcgccgtttt cgcctatttt atcctctaca tcctgtttac 2200381 ccaatttaat gccttcttga actgcttctt cttttgtata ttttcgcaaa gcctcttcac 2200441 tttctctcgt ttgctctttg acataggata cagggagctt aaatccgaga aaatgaagcg 2200501 aatgcttttc ttgttctgtt tttggatgct tcaattcctc ttttttaaac gtcatccccc 2200561 agatcgggat tgccaaagaa ccaaaagaaa gcttgtgctt tgtccttact ttgcccgtat 2200621 agacgttaaa taatgtttca agcgggactg tcacttctga tctataccag gtttctccat 2200681 aaatttctgc ttttgaggcg acttcctgct gatggtcttc gctgccgatc agtcccgaaa 2200741 caagcagctg tcccttttca acatgatcgt gtatggcggc catgggctgt cctttttgca 2200801 caaacattct cgtaatggtt gctttctttt tggcgacaat attgcgcggg ctaacatatt 2200861 tttctttttc gggctcattt ttctccacaa ctttcatatg aatggtcgtc cccttcagat 2200921 caactccgac ccaagtgata ttgtctattc cattggttaa tgatttctgt attttttcgg 2200981 gcgacatcat taaaaactgc agacggccct ttttgacgcc gatttcatta agatgctgcc 2201041 tcatttgatg ttctgtttca ggcttagcgc ctgtcacatc aattttccac accatattgg 2201101 acagcaaaaa caaaagaatg aaaaaaatcg caaaaccgat cgtaaaccct atattcagct 2201161 ttgatttcag caacaggaag ggaaatccct tccgattgat aaatcgggct ttacatttaa 2201221 atttacttct tacccgccga aaggcatgta catcctgaag ctgtatatat aacgatacgg 2201281 cttctttctt ttttttgaca tgaaagaccg gaatcccctg tcttgtgcat tcattaagga 2201341 gccgctcaat ccctcttccc gtcaattcaa gctggacctt acccgaaaaa aaagacagcc 2201401 atttattttt cacaacattt ccccctcggc tttatgactc aacatatcga acgacatcaa 2201461 tcgtaccctc caaaagtatc tcttccggaa gaatcgcctt gatgacaaaa tttttaccag 2201521 atatgatgca ctggccctgc ttcagcatca gccgcacttc attctcactg aaaagcaaaa 2201581 ggcctctgtg gttttctatg tagatatgaa gtctgccaac cattgtaatc ctcggcagat 2201641 ccatcataac gtccggggga atttccaatg ctcttgtcag ccaagctttc atacgattct 2201701 ttctttgccc catacaaaaa gaaccccctt tcatctcata tgtatgattt gaaaggaggt 2201761 tctaacactt taatttttac gggccgggcg catcgtacgg tgaggttttt tcgcccgtgg 2201821 aggtccgaac acctctccta gaacgatccc ctgtacgacg gtgtctttat tcacctgaag 2201881 cattttttgt tttgtgtata ctgttttttg tttggcagca gcaagatctc gttccagccc 2201941 tttcaggttt cttgctgttt ccctgcgtct ttcttccgct tcccgtcttg cctgttccat 2202001 acggttaggg ataggtgcag gggcatcttc ttttgactgc ttcttttgag gagaagcaga 2202061 ttgcacgtgt tgaggttttt ttcttttttg gctgttttgc ttttcttctt tgctcttttt 2202121 gccgaaaatc gcagaaatga ttccgatgat cgctgcaata ataagcggat tggtcagtaa 2202181 atcttccatc agcgttctcc cttcttagag agattatgat ttgcggtctt catccgaagg 2202241 gtctttcgtc agcttgccga atgaatcacg catttctgtg tcagcatcga tgttcttgat 2202301 attcatgtaa tccatgacgc caatattccc ttcacgcaaa gcttctgcca tcgcaagcgg 2202361 cacttccgcc tcggcttcta ctactttcgc gcgcatttct tctacgcggg cacgcatttc 2202421 ctgttcttga gcgacagcca tcgcacgtcg ttcttccgct tttgcctgcg cgatgttttt 2202481 atcagcctcg gcctgatcgg tttgtaaaat tgccccgatg tttttgccga tatctacatc 2202541 tgcaatatca attgagagaa tttcaaacgc agttcctgag tccaatcctt ttccaaggac 2202601 tgtctgagaa atcatgtcag ggttttcaag cactttttta tgattatcag atgaaccgat 2202661 tgtagaaacg attccctcac ctacacgagc tacaatggtt tcttcccctg ctcccccgac 2202721 gaggcgctcg atattcgctc ttactgtgat tctcgctttc gctttcactt caatcccgtc 2202781 cattgcgacg ccggcaatga acggtgtttc aatcacctta ggattaacgc tcatttgaac 2202841 agcttccaac acgtcccggc ctgcaagatc aatggcagca cagcgctcga atgtgagttc 2202901 aatgttagct cgctgagcgg cgataagcgc gttgacgact ctgtcaacat tacctccagc 2202961 cagatagtgg ctttcaagct ggtttgttcc aacattaagt cccgctttat gcgctttaat 2203021 cagcgggtta acaacccgat tcggaatgac gcggcgaagc ctcatcccaa ctagagtgaa 2203081 aatgctgatt ttcactccgg ctgccaaagc tgaaatccaa agcattacag gcacaaatgt 2203141 aaaaaatact gccaaaacaa tgatcgctac tgcgacaatt gccagaatca taagtgttga 2203201 cggatccata taacttctcc tcgtttctat ttaaatttct ctcacgacaa tgcgtgagcc 2203261 ttctactttt atcactttta cttttttatc tttttctgta aacgatccct ccgatacaac 2203321 gtcaaggcgt tcatcatcaa taatcacggt accggaagga cgcagcggtg taaaggttat 2203381 acccactttt cccattaagt ccgtgcgcgt ttgatttgaa acgtagccgc tctccgtgtt 2203441 tgtagaatca tttaatatca atttcttaaa gaatttcata cgctttccca acacccttgt 2203501 cagtaaaata aaagctgtaa tcgaaacagc tgaggcgatc aagagagaaa ccgccatgac 2203561 agtgaagctc cccgcggcta aaaacaggct cgcaataatc gctcccaagc ccagtaatcc 2203621 aatgattcct ccgggaagaa aaatctcaag cagaatgaga atcacccctg ctataaagag 2203681 gagaaccgtc tcatacccgg caaggccggc tgcaagatgc ccgtaaaaga acagcaataa 2203741 cgcaatgagt ccagccgttc cagggaggcc gacacccggg gaaaaaagct ctaccgtcag 2203801 acctaaaaaa gcgattgtca gcagaatagg gacaatgacc ggattcgtca gccatcttgc 2203861 cgtcttttcc gcaaagctct cctttgcata gctgatctgc gccttttcga acccaagctt 2203921 ctttacgagc gtggacaaat tgtcagcagt gccttctgaa tagcctacct caatcgcctt 2203981 gtctgcgtta agtgtcagca gatctccctt aggcgcgcca acttccttgg catctatatc 2204041 tgggtcagcc attgcgagcg catattttgg atcgcggtta tttttcactg cggcatcttc 2204101 catctctgcc agccaaagtg attgagcttt ttggtcagcg gcattgcctt ggccatcaac 2204161 aatcgcggcg gctcccattt ttccgccagg cgccatataa atgtgatctg cttgaagtgc 2204221 aatatatgca ccagcagaca acgcgcgttt gttgacatat gcagttacgg ggatctcgct 2204281 ttcggttatc aaatcggcca tatcaatagc agatttgacc aatccccccg gggtattgat 2204341 atcaagaata atatggtctg catgtgcatc ctttgcgtct tgtaacgaac gggacaaaaa 2204401 cgaggcgaga ccctgttcga catttttttc aaccgggatc acataaacag tttgtttttc 2204461 tgcttttgcg ttcagctgta cgcctaataa agaaagtaaa aatataccca aaagagcagc 2204521 acggaatcct ttgatttgaa gcaagggcgg tgtatccctc cttcctttta taataagtgc 2204581 cttctcttca tacgtaacaa atgtatcaaa ggtttcattt ttttatgtat aaaaaaagac 2204641 atctctctta gaaagatgtc cttttctttg ccatttaaga cagttgactg ctcacaagct 2204701 tattaattaa acttccgtca gctttacctt ttactttagg cataattgcc cccatcactt 2204761 tgcccatgtc cgcttttgag ctcgcaccga cctccgcgat ggtttcattt acgattgtac 2204821 gcagctcttc ttctgacagc tgctcaggta aataaacttc taaaatgtcc agctcttttt 2204881 gaactttatc tactaaatct aaacgattag cgtttgaaaa ttcctggagg gagtctttac 2204941 gttgcttaag ttcacgagaa aggacagtga gttcctcatc ctcggtcaaa ctgtctttct 2205001 taagcttaat tgcttcattt tgaagtgaag ccttaaccat tcgaacgaca gtcagtttgt 2205061 ctttctcacg gtttttcata tacagcttca tatcctggtt gagacgctca agaagactca 2205121 taaatccacc ctcttttaga atttgcgttt tctagcagct tcagactttt tcttgcgctt 2205181 tacgctaggt ttttcataaa attcacgctt tcttgcttct tgcaaagtac ctgtctttga 2205241 tacactgcgt ttgaagcgac gaagagcatc ttcaagcgat tcgttttttc taacgaccgt 2205301 ttttgacatt ctctttccct ccctccgaat acaccaatcg actaccttta agttacacat 2205361 ataaacatgt actttgacat tataatataa gccatcagtc aggtcaacta agtgagttca 2205421 cttttccgtc atgagtgcga ctgcctgtct atataatgaa agaaaggggt tggtgaatag 2205481 gatgttaatt ctgattagct ttactgctct tatattattc tttctcgcag gcatgaacat 2205541 gcttcgaaag ggcttaattt caatggcgta ctcaaaaatt gaagaacgtt tgcttttatt 2205601 tacagaccat ccgttaaaag cgtttcttat cagtattgta tttacgggga tacttcagag 2205661 cagctcagcc tttatggtca ttgtcatcgg ctttgtaagt gcgggcgttc tttcttttaa 2205721 gcggacgatc ccgatgattc tggggacaaa tgttggctct acttttacaa ctgaatttat 2205781 tgctatcaaa atggatattg tgatttgggt tcttttaata ggaggtttat tgttttttct 2205841 gactggcagg tatcctttga aacagctggg aacaagcttc cttggactgg gcatcatctt 2205901 cttttgcatc agcggattca gccatcttgc cgggccgctg acaaagctga aaacgggcgc 2205961 cgacgttcta taccatgtta acgattcaaa ctggtccgct ttgctcatcg gcatggtgtt 2206021 aactgccatc attcactcca gttctgtctg tatcggcatt ttgatgagtt ttatgaatga 2206081 agggattatc ggactgacac aggcgatgag cgtcgtactc ggatcaaata tcgggacatg 2206141 cattacagct gtcatggctg ctgtatccgg cggatatgcg gcgaaacaga cagcatatgc 2206201 ccatgtggta tttaacgtgc taggggtggc tctagtattg ccttttctga ccgcagcgac 2206261 cggctttgta gagcagttat cacctgatcc cgcacaaaag atcgcgcatt tcagcctttt 2206321 atttaatgtg gtgacagctc ttttatttct tccgcttaca aacttgtttt accgattgat 2206381 tcaccttctt atcccggcta aataaaaaaa tcggtacatt ttaatgcacc gattttttag 2206441 gttaagaaga caaacgcatg tgttcagtta tttcatcctc aaccacacgg acaaactgtc 2206501 cttcgttgta aggataacct gcttttagga ttttgacttt tacgattttg ccgatcatat 2206561 cttccgtacc tttgaaaaca accttcatat aattgtctgt gtaaccgaca aacatatttt 2206621 cttcttctgt ttccttaaac gcttcctcag ggataatctc aagcacttca ttttcatact 2206681 gagaagcgta ttcttttgca agctggtcag aaagagcaat caggcggtgc acacgttcgt 2206741 ttttcacgtt ttcatccact tggtcttcca ttcgtgcagc tggtgttcct gtacgcttac 2206801 tgtaagggaa aacatgcagc tcagagaatt tatgttcttt aataaagtta taggtttcca 2206861 taaattcttc ttctgtttct ccagggaacc cgacgatgac atcagaagta acagctaagc 2206921 ctggcagtgc ttttttcaat ttatttaaac ggtctgcaaa gaattccatt gtatatttgc 2206981 gtctcatccg tttaagcact gtgtttgatc cggattggat aggaatatgc aaatgattca 2207041 ctatcttatc tgagcggtct aagacctcga tcacttcgtc agtgatttgg ctggcttcga 2207101 ttgaagaaat tctgatccgt ttcacgcctt ccacacgggt gtctaattcg ctcaaaagct 2207161 tcgcgaagtt gtaatctttc atatcttcgc cgtagccgcc tgtatgaata cccgtaagaa 2207221 caatttcctt atatccggca tcgacaagct gctgcgcttg tttaatgact tcttcagggt 2207281 cgcgggagcg gagcaggcct ctcgcccacg gaatgataca gaatgtgcag aaattattgc 2207341 agccctcctg tattttcaat gacgctcttg tgcggtccgt gaaagcaggc acatcaagct 2207401 cttcatatac tcttgctttc atgatgttgc tgacgccatt aatcggctgg cgttcttctc 2207461 ggtattggtc aatgtagcca agcatttttt cacggtcctg tgttccgact acaatgtcga 2207521 caccggggat cgccataatc tcagcaggtg aggtttgcgc gtagcagcct gtgacacaga 2207581 tgacaccgtc aggattttga cgaatggcgc gtctgatcac ttggcggctt tttttatctc 2207641 ccgtatttgt aaccgtacat gtattaatga catatacatc agctgtttgt tcaaagtctc 2207701 ttctttcata gcccgcttct ttgaaaagct gccagattgc ttctgtttca taatggttga 2207761 ctttacagcc aagcgtatgg aaagcaacag ttgccattac tgatcacctc ttaataactc 2207821 tgtttgataa gaaatcgcac tcaacgcgta tagcggagcg gtttctgtcc ttaaaattct 2207881 cggtccaagg ccgcacgtca caccgtcttg ctctgtgagc cgttcaacct ccgcttctgt 2207941 taaaccgcct tcgggaccaa atacgatcaa tagagatgat cctttcggaa ggctgcttac 2208001 aatcgcgctg aatgcgctta tttccccttg cttcgatgac tcctcgtatg caacgacaca 2208061 tttatcgaaa tcctgcatcc tttgaagaag ctgctgaaaa gaatggacat ccatcactcg 2208121 cggcacttcg ttacggtacg attgctcagc cgcttccttc gcaattttcg tccatctttc 2208181 ccgctttttc tttgcctttt tgtcatccag cttgacaaca gaacgcgcgg cttggaaagg 2208241 aataaaggca tgagctccga gctcagtccc cttttggata atccattcaa gcttatctcc 2208301 tttcggaagg ccgctcgcaa tatagacctt tatcggaagc tctctgtttt cattcgtcca 2208361 ttctatcaca aggcaggaca ctttatcttt ggaaacagat tgaagttcac attttgcctc 2208421 gaagccgtct tgagagcagc agataatctg atctccctca ttcattctca tcacgttcac 2208481 aatatgatga acttcttcgc cggtaatcga aaaagtcggc gcttcctcta tttgctgctt 2208541 cgtgagctcg ataaaatatc gttgcatacg ctgtgacacc tactaactgt tattttttcg 2208601 caataatgct gacccaatct tccattgaaa ggatttctac aatggtaaag ccagcttgtt 2208661 ccagtgcttc ttttacttct tgttttttat gaccgatgat tcctgacgta ataaagtgac 2208721 cgccttcttt taacaggctg tacgcttgtg aagtaaagcg aagaatgact tcagccaaaa 2208781 tgttggccac aatcacatca tgttcccctt caatcccgtc taacaaattg ttttgcttca 2208841 cttgagcaat atcgctgact ttgttcagct tgagattgag gcgtgcactt tctacagcca 2208901 cgggatcaag atcgtaggca tgaaccgatt cagcctcaag cattgcagcc gcaatactta 2208961 aaattcccga accagtgccg acatcaatca ccttatcacc cttttgcaca aagcgttcaa 2209021 gcgcctgaat gcagagtacg gttgtcggat gtgtccctgt gccgaaagcc attcccgggt 2209081 ccatttcaat aatcagttca tcagtatgga ccggcgtata ttcctcccac gtcggcacaa 2209141 ttgtaaactt ttcagaaatt ttcacaggat gataatactt tttccaggca gtcgcccact 2209201 cttcttcatt tacttcagaa atagtgatgt ggtttctgcc caaatcaata ttgtaaagaa 2209261 ggagattatt aatcgtttct ttgatgccgt ctacagtttc gcccagaaaa ctgttaaccg 2209321 gcagatatgc tttgacaatg acaccctcat ctgggtaatc attggggtcg agctggtaga 2209381 tttccccgta cacattctca cgttctttaa ttaaatcaag cgggtcctct atcacaaccc 2209441 cacttgcacc agcttcatgc aatatatttg agataggttc gaccgcttca tgtgttgtgt 2209501 gaatgcttaa ttcggaccat ttcaaaacta ccaactcctc atccaataat taatcgcctt 2209561 taaacgcgcg ttttaccttg tcaaagaaac tcatttcctg ttcgtcaggc aggtttccgc 2209621 tgacttcggc aaattcgcgg ataatgtctt tttgtttatc agtcagattt gtcggcgtaa 2209681 cgacgcggac gacgatatgc tggtcaccct gtccatagcc tctgacattt tgaacgcctt 2209741 tgcctcttaa tctgaatttc gttcctgttt gtgtaccggc cggaattttc aatttcactt 2209801 ttccatgcag cgtcggcact tctacctcat ctccaagagc agcctgagca aacgttaacg 2209861 gcatttcaca gtaaatatca tcgccgtcac gctcgaagaa ctcgtgtgcg cgtacatgga 2209921 acacgacaaa taaatccccg gcagggccgc cgtttattcc tggttcaccc tgtcccgaga 2209981 gacgaagctg ctgcccgtca tctacaccgg ctggaattgt cacattgatt ttcttgcgtt 2210041 ttttgatttt tcctttgccg ccgcagtccg cacatttgtt tttaatgatt ttgcctgtac 2210101 cttcacagtg gtggcagacc cgtctgttaa cgacttttcc aaacggtgta ttttgctcca 2210161 cgtttaactg gccggagcct ccgcagtggg agcatgtttc tggatttgtt ccaggtttcg 2210221 cacctgagcc tttacatgtt tcgcacgttt cctcgcgggg aatttcgatg gttgtttctt 2210281 taccgaaagc cgcatcctca aacgacaggg tcatcgtata ctgtaaatca gcaccctggc 2210341 gcggagcgtt tggatctctt cgtcttgtgc ctccgccgaa tatacttgag aaaatatcat 2210401 cgaaaccaaa accgccgaaa tcgccgccgc caaaacctcc gccgccgaag ccttggttag 2210461 ggtcagtgtg accaaattga tcgtaatgcg cacgtttttg gtcatctgac agcgtttcgt 2210521 atgcttcttt tacctcttta aatttttcat ctgatccggc ttctttgtta atatcaggat 2210581 gatatttttt tgacagcttc cgataagctt ttttaatttc atcctttgaa gcgctcttac 2210641 ttactcccag cacttcatag taatcacgct tactcatctc gcttcactct cccgaatttc 2210701 tcacataaat tagattgtat cattttgaat tatgattttt caattccttt tatcccgggc 2210761 aagaaaaaaa gtcaaagcca agagatgcct gactttgact ttctaatcat tgaatcagat 2210821 tatgaaatgt gttcttttcg gtcagctccg gaagcggggc tgacactaaa aagaacttat 2210881 tttttgtttt ggtcgtcgtt tacttcttcg tattcagcgt cgacaacgtt gtcatccgct 2210941 ttgccttcag cgtttgctcc gccttgagct tgctgtgctt tagcagcttc ttcataaagc 2211001 ttcatagaaa gctcttgaac gattgtttga agctcatctt ttttcgcttt gatctcttca 2211061 aattcgtttt tctcaatcgc tgcttttaaa gcgtctttgg catcgttggc ttttttcact 2211121 tgttcttcgt ccactttgcc ttcaagatct tttaatgttt tctcagtttg gaaaacaagc 2211181 tgatctgctt cgttgcggac ttcgatttct tcttttttct tcgcatcagc gtcagcattt 2211241 tcttccgctt cttttaccat gcgttcgatc tcttcatctg agagacctga agaagatttg 2211301 attgtaatgt tttgttcttt tcctgtgcct aagtcttttg ctcttacgtt tacgataccg 2211361 tttttgtcaa tatcgaaaga aacttcgatt tgaggcacgc cgcgcggtgc tggcgggata 2211421 tcagtaagct ggaagcggcc gagtgttttg ttgtcggcag acattgggcg ctcaccttga 2211481 agaacatgga tatcaacagc tgtttggtta tcagcagcag ttgagaacac ttgagatttg 2211541 cttgttggga tcgtcgtgtt gcggtcgatc agttttgtaa acacaccgcc cattgtttcg 2211601 ataccgagag aaagcggtgt aacgtcaaga agaacaacat cttttacgtc acctgtgata 2211661 acgccgccct gaatcgcagc accaagcgct acaacttcat ccgggtttac gcctttatgc 2211721 gcttcttttc cagtttcttt tttgattgct tcttgtacgg cagggatacg agttgatccg 2211781 ccgacaagga tgactttgtc gatttcgctt gcagaaagtc ctgcatcttg aagcgcttga 2211841 cggacaggac ccattgtgcg ctctactaaa tgagaagaaa gctcttcgaa tttagcgcga 2211901 gttaatgtaa gttcaaggtg aagcggtcct gcttctccag ctgtgataaa cggtaaagaa 2211961 atttgcgtag aagatacgcc ggaaagatct tttttcgctt tttcagctgc gtctttcaaa 2212021 cgctgaagcg ccattttgtc ttttgacaaa tcaatgccgt tttctttttt gaattcagac 2212081 accagatgat cgatgataac ttggtcaaaa tcgtccccac ccagacggtt gtcgccggca 2212141 gttgaacgaa cttcgaatac accgtcgcca agctcaagga tggaaacgtc gaatgtaccg 2212201 ccgccaaggt cgtatactag gatcgtttga tcttcatctg ttttatcaag tccgtatgca 2212261 agcgctgctg cagtcggctc gttgatgata cgttctactt caagacctgc aattttacca 2212321 gcgtcttttg ttgcttgacg ctcagcatcg ttaaagtatg caggaactgt gataactgct 2212381 tttgatactg tttcgccaag atagctttca gcgtatgatt taaggtgttg aaggatgata 2212441 gcagacactt cttgtggagt gtaatccttt ccttcaattt caactttata atcagtaccc 2212501 atatgacgtt tgatagacat aattgtgtta gggtttgtaa tagattggcg tttagccact 2212561 tcccctactt gacgttcgcc gtttttaaat gcaacaactg atggcgttgt gcggtttcct 2212621 tcagcgttag caataacttt aggctcgccg ccttcaagca ctgccacaca tgagtttgtt 2212681 gttcctaagt cgattccgat aactttactc acttgaataa cctcctgcta tgtaattatt 2212741 gattcacttt gaccatggaa gggcgaatga cgcgatcctt cagcttatag cctttttgca 2212801 tttcctcaac aacaatgttg gagccgtagt tttcgtcttc agcctgcata acagcttggt 2212861 gcagattagg atcaaattcc tgccctacag cttcgatggc ttcgacgcct tcttttttca 2212921 aggcttctac gagctgacgg tggaccattt ccattccctg gagcaaactt ttcgtctgtt 2212981 cattgtcggc ttcaacctga agcgctcgtt caaaactgtc aagagccggc agcaaatcag 2213041 tcacgatatt ttgagaacgg tatttttggg acgcttccat ctctaaacgg ctgcgtcgtt 2213101 tatagttttc aaagtctgct tgaacacgca aaagtttgtt ttctttttcc tcaagcaaac 2213161 cttgcaattc gttaatttgg ttttgaagaa gttcgctttc atttgtttct tcctgctgtt 2213221 catcagcggc agcttgttct tcaatgattt cttgctcttc tgtttcgttt tgttcaacgg 2213281 tttgtttttc ttctgacatt gtgttcacct ccctcaaagt gtaaggagaa ggacaggtgc 2213341 tgcccttcga taaaatttgc caaaattccc ttattcatca tacagacttg ttaatgcttt 2213401 tgacaagtcc gaagtcacat gctgaagcag gctgacaacc ctggaataat tcatgcgggt 2213461 cgggccgata atcgcaattg agccgatctg cttctggtct acggaataag aagccgtaat 2213521 cagactgcaa ttttccatct cttcatagtc gttttctttt ccgattttaa tcgaaattcc 2213581 cgtgtgcggg gattgaacca gctttaaaac atcctgttct ttctcaatta atgaaagcag 2213641 cgaccgaact cgggtgatat catggaactc aggctggttc agcatattga ttttcccgcc 2213701 aaaaaacaac ttttcaacgt gatttgtgga atgaaaggtt gaacgaagcg cgtcgagtat 2213761 attgtcatag tttttaatgt gctgtcttag gtacatgaca acttctttaa atatgcgctc 2213821 attcagttca tccattggaa cgccgcttaa acggtcgttc agtatattta ccagtttttc 2213881 aatatcagac agatccattt tggtcggaaa gttaatcgtt ttgttttcca catgccccgt 2213941 attggtaacg agaatcgcta ccgccatatc aggctgaatc ggaatgattt gaatctgttt 2214001 aaggtaattc tcactcaact tcggcccgag tacgatggat gtgtaattcg tcagatcgga 2214061 caaaatttgc gctgattttt gaactgtctt ctccagctcg aaaattttct ctttgaagat 2214121 cgagtggatt tggtccaggt cgcttttcgt caatttgacg ggtgacagca aatggtcaac 2214181 atagtaccga tacccttttt ctgacggaac acgtcctgag gatgaatggg ttttttcaat 2214241 aaagcccaat tcctccaagt cagccatctc gtttcttatt gttgcagagc taaatgtgat 2214301 ttcatctttt ttcgaaagag ttcttgatcc caccggctgt gccgatttaa taaaatcgtt 2214361 gattataacc tgaaggatca gcagctgacg atttgttaac atcatcatca cctctgttag 2214421 cactctcaat aagcgagtgc taattctata acaaaagtat caaaccacaa gaaaaatgtc 2214481 aattataact cacccaaaaa agcgccaaaa acttcattgc ctaataattt cccttgatga 2214541 gtcaaataaa cggcagactc cgaattgtga atcagccctt tttcagcgag gtcttttaac 2214601 acgcttggga aaagtccatc cagggaacgg ccgtattttt ctgcgaatcg ttttttgctg 2214661 acaccggctg tttttctcaa acctaaaaac atttcttcct caatctgttc ttctgttgtc 2214721 acttcatgtg tatctctgta cggaaaaccc ttttcagcta tcaggtcaat gtaatgctta 2214781 acaggtccga cgttcactgt tcgtgtgccg ccaatatatc cgtgagcgcc agctccgaaa 2214841 ccgaaatatt gttcgttgct ccaatacgtt agattgtgct tagattccat gcctgcctta 2214901 gcaaagttgc tgatttcata ttgatgaatg ccgtgagctt ccatcttgct catcactatt 2214961 tcatacattt cagcttcctg ctcctgcggc ggaagatgaa gccgcccttt ttgcatcaaa 2215021 ttataaaata ccgttttcgg ttctacaata agggagtaaa cggaataatg ctcagcgtcc 2215081 aatgataaag cagtgtttat ggaatgttcc agatgcttga gggtttgccc cggaagcccg 2215141 aacatgagat caagactgat attctcaaaa ccgatttccc gcgctctttc aaaagaggtg 2215201 aatacatctt tttgcttgtg cactcggccg attttttcta acagatcgtc ttcgaacgtt 2215261 tgcacaccaa agctaaggcg atttacgcct gcttctttta atatttttaa tttctctgcg 2215321 gacaaatcgt ccggattcgc ttcaaccgca aattccgata agtcgcttga gggctttagc 2215381 acgcggttga tcatatccat cagcttttta agctgttcct cagacaggga ggtcggcgtg 2215441 cctcctccga taaagattgt tttgagatca ggctgcccgg tttttgctat tgtatttatc 2215501 atttcctgtt cgagtgcgtt taaatactcg tcgactggct gactttgaat aaaatattta 2215561 ttgaaatcgc agtagtggca aatatgctca caaaatggga tatggatata agctgatttc 2215621 aacggattca ccttctttac agaaagaagc cgcagtacaa gactgcggcg gcttctattg 2215681 ttttttcgga ctgtcgtcca ttttcagaac tgccataaat gcttcttgcg gcacttcaac 2215741 tgagccgacc tgcttcatac ggcgctttcc ttctttttgt ttttcaagaa gtttccgttt 2215801 acgcgagatg tcccctccgt aacatttagc caatacgttt ttacgcattg cttttatggt 2215861 ggagcgggcc acgattttct ggccgattgc ggcttgtacc ggaacttcaa actgctggcg 2215921 cggaatgagt tctttcagtt tttcaacgat cacttttccc cgttcatatg cgtaatcacg 2215981 atgcacgata aaggaaaggg catcgatttt ttcaccattc agcataatgt ccattttcac 2216041 aagcttggac ggtttgtagc cgatcagttc ataatcaaag gacgcatagc ctttagtgct 2216101 tgatttcagc tgatcaaaaa actcatatac gatttccgct aatggcatat cataaatgat 2216161 gctgacacgg tttgcgtcta aatactgcat atcaatgaaa ttgccgcgtt ttccttggca 2216221 aagctccatt acagcgccga catagtcatt cggcaccatc atcgtcgctt ttacgtatgg 2216281 ctcctcaacc ctttcgatct tttgaggatc cggcatgttg gacgggttgt cgacaacgac 2216341 cttttcgccg tctgtcatat acacgtcata gataacgctt ggcgctgtcg taatcaggtc 2216401 gatgttgaac tcacgctcaa ttcgctcctg aatgatctcc atgtgaagca tgcctaaaaa 2216461 tccgcagcgg aacccgaatc caagcgcttg cgaagtttcc gcttcatatt gaagggagga 2216521 atcattcagc tcaagctttt caagagcttc ccttaaatca ttatacttcg ctgtatcaat 2216581 cggatacaaa ccacagtaca ccatcgggtt tagcttgcgg tatcccggca gcgcttcttc 2216641 tgcaggattg gcagcgctcg ttattgtatc accgacacgt gtgtcaccaa catttttgat 2216701 tgaggcagtc aggaagccta catcaccgac cgtcagttca tttgtcggag ttgctttcgg 2216761 cgtgaacacg cccacctctg ttacttcgaa ttctttgccg gttgccatca ttttgatttt 2216821 ttgtcccggc tttaccgttc cttcaacgac tctgatataa gccacgacac cgcggtaggc 2216881 gtcataaagc gagtcgaaga tcagcgcttt gagcggcgcc tccggatctc cggtcggagc 2216941 tggcaccttt tctacgattt gttctaaaat ctcctcaatc ccgataccgg cttttgctga 2217001 agcaagcacg gcttctgatg cgtcaaggcc gataacgtct tctacctctt ggcgcacacg 2217061 ttcgggctcg gcgctcggaa ggtcgatttt attgatgacc ggaaggattt caagatcgtt 2217121 gtcaagcgct aagtagacat tggcgagcgt ctgcgcttca atcccctggg ctgcatccac 2217181 gacaagaatc gctccctcgc aggcagcaag gcttcgggat acttcatacg tgaagtcgac 2217241 gtgtcccggc gtatcgatta gatgaaagat atattcttct ccgtcttttg ctttatattt 2217301 aagctgaaca gagtttaatt taatggttat gccccgctca cgttcaagat ccatagaatc 2217361 gagcaattgt tctttcattt ctcgttgagt gattgccgac gttttttcta aaatacgatc 2217421 cgctaaggtc gattttccgt ggtcaatatg ggcaatgata gagaaattcc gtattctcga 2217481 ttgcctctct aaacgctttt ctttatctgt cacaatctat cactcctact attaaacgca 2217541 aaatacacta gcttagatta tatcaatagg attgtaaaga ttcaatgtaa aacaagaaag 2217601 agaaaagttc cctatcatat ctgggttgct tttctctttc acgtacttat tgattcatat 2217661 cccgtatcca ttcatacatt gactgggcag tattggttac ggtgtccgaa agcgcttttc 2217721 cggcttttga aaacatattg aatgtctcca ccttttccag ctctttttgt ttttctacta 2217781 aatcttttgc cgtgactgtt tctcctagga ttgaggcttc tttttcatta tcttttccgt 2217841 cggtgagcgt aaacgccccc ttcagtgaag ggtcatgata gcctttcata ctcagcatcc 2217901 cgtggtttgc ctgctgcatg ccgaacagaa cgcctaaaaa catgatcgtg acaagcagta 2217961 agcactttcc aaagtatgca atcaaatcaa ccacctattt cttattgttt tttcgtctcc 2218021 ccgctcgctg cgttgacctt ttcagcatcc cagtacattt cgctgaatac gtccgcggcc 2218081 gcgttagccg cacgctgcag ctcttcgaga ttattatcca ctccgccaaa ctcgagcaaa 2218141 agcgctctat cggttaaatc ctgattgtaa acaccattat cgcctggcga gcctttggaa 2218201 aagacacctg tgctaagtcc ggggtatttt ttctccatca gtttatgaag ctcactcgca 2218261 attttatagt tttcttcgaa gtttttgctt tttttcccga cgacaaaggc taccctggca 2218321 tagcttttcc ctttaatcgt tgcggttgtg tcttttttgc gccgagagtc tctgtggatg 2218381 tcaatgatat attgcagatt tttgtttgaa gcgagggcgt ctttcacgac cggccttgat 2218441 tcatcatagg acctggcata gtttaagcct tttttattca attttgactg tatatcggtt 2218501 ttattcactg tggctccgat tccctgggat tcaagcgctt gtccgaacat atctcctaca 2218561 agcgtgacat tggctttaga atggcgcgcc atgtcaggat cggtctcgcc ttttaataga 2218621 gggagatatg attccgtatt gtgcgtgtga tagataaaca cgaccttttt atcacctgtt 2218681 gtttgtttcg gcggatcttt ttgcgcatta tctgattgcg tttgctgttt ttcaatctct 2218741 gccaaattcg cttctctttc ttcctccatc accttagacg gcggcggcga ttccgcaggc 2218801 atattcgtat aatccgttcc ttgtccagct aacaaaatct cggtatcaaa ttgtgcaaat 2218861 cctggcagct cccgaccgag aaagctccgc ggatcttcga ggttaatgct cgtcgccagc 2218921 tttaaagaaa gacgagaaag atgaaatgag ctgtctgttt gagagaggtc agaagcgaaa 2218981 taatggtttt ccatctgcag caaatgtgca aatacgtcac ccggcaattc ttcagcaatc 2219041 ccataaaaag agtcagacga cggcctaagt tccggccgga gagacgtcag cacaccggat 2219101 agaacaaaaa tcacgataag gcttacgata aatagaaaga tggcttttac cgctttccct 2219161 ccatttaccg caacaacaat ctgtctgttt ctgcgtttat ttctcattga atccctccag 2219221 cgcttgtcta gtaattactc tatgaacaag ctagaggaag tagaactgtt tagtgattgt 2219281 aggagccttt gttttcttgt gacacttttt catgaagcgc tgtgtttaat ccgttcgcta 2219341 aaacatttgc catatcgtcg ataaatgaat cgacttcctt cggtgtaacc attaagttgt 2219401 gccctaaagg cgaaagcacc tcgtgaatga gctgccgttt ttcatcttct tgaagggttc 2219461 cgacaatacc taggaacgat tggcgctgct tttgatcggg aagatcgtct tcagtgagca 2219521 ctttcttttt cccaaacgtc atgcctgccg gaacaagcga tcttgatggc ctgttatcct 2219581 tcatttctct gccaaaatgt tttaatatgt agtccaccgt gtcgctggca attgtcacgg 2219641 catcaactac tgtcggaaca ccgatagcaa tcaccggaac accaagcgtg tctttgctta 2219701 aatcttttcg tttattcccc actccagacc ccgggtgaat gcctgtatcc gatatttgaa 2219761 tggttgtgtt gaccctttcc accgcccgcg ccgccaacgc atcaatggcg atgacaaaat 2219821 caggcttcga ttgctcaatc acacctttaa taatgtcact tgtttcgatt cctgttatcc 2219881 ccattacacc cggtgcaaaa gcactgacag gcctgtaacc ctcctgtacg ttttccggct 2219941 gaagcttaaa caagtgcctt gttaccaaca gattttctac tgccatcggt ccaagcgcat 2220001 caggtgtcac gttccagttg ccgagcccaa cgatcaaaca gctcgcatct tttgagatat 2220061 taaggttttc aagaaaagct gagaattcct ccgcaaagac agcagagacc ttctcctgca 2220121 tttccgaatc attctccctg attccctgtg cttcaagcgt taaatagcgc ccttcttttt 2220181 ttcccgaaag ctctgcgcct tcctttgtaa catcaactgt gcggatttta atgccgccgt 2220241 gatcacgctc tttttcaata aagcctttaa tttcttttgt cggcacagcc tgctgattgg 2220301 ccattgcttc cttcgtttcc actgccaaat cggtccgtat caaatactga ttcacatcca 2220361 gctcactctt tttcatacag gggcctcctt cacattaagt acctatattg ttgccatttg 2220421 ctgaataaat catgctaaaa agagaacctt caatgaaaaa tactttacat ttatattgca 2220481 atctaaaggt gtgtttgata gaatacaatt tgttctattg tgaagaagat ttaaccttaa 2220541 gacactgtgc tacaggttgt atcttaggag gtgaaacaca tgccaaacat taaatcagcg 2220601 attaaacgta caaaaacaaa caacgaacgc cgcgttcata acgcgacaat caaatctgct 2220661 atgcgtactg caatcaaaca agttgaagct tctgttgcca acaacgaagc tgacaaagcg 2220721 aaaactgctc ttactgaagc agctaaacgt attgataaag cagtgaaaac aggtcttgta 2220781 cacaaaaata ccgcagctcg atacaaatca agactagcga aaaaagtgaa cggactttct 2220841 gcataatata aaaacgatcc tcaataatgg ggatcgtttt tttcatttct ttttaacagc 2220901 tgtaaaagga acagttcgag caggagctgc ttgtcctttt tcccggtttt catctcatag 2220961 tccatgacgg caagctgttc aataattaaa cggagctcct cctctgaaaa aagccttgct 2221021 tgatccatcg ccagctttac ccgaaatggg tgaactttta gattagaagc gatttgtttt 2221081 tgtccgtatc cctgttccgc gaagtacttc gtctgcagaa tcagccggaa ctgattcgaa 2221141 ataagcgcca taattttgat cggttcttca ttttgtttta gcaaatcata aaaaatttgc 2221201 agactctctg ttcgttttcg gttgacgatt ttattgatca gctcaaaaat attttgttca 2221261 aggcttctag caacaagcat ttttacatca tccagcgtaa tttcttcacg atctccaata 2221321 aacgtgcaga gcttttgaat ctcctgaaaa atcgatgaca gatgaccgtt cacaagcaga 2221381 accaaatgct ccgccgcttc cgtgccgatt gttttctgct ctgtttttgc aaggttgaca 2221441 gtaaagtctg tcgtttcctt tgcatttaat tccttcgcct ccatcataaa cgcgtgcttc 2221501 tttaacgctt tcgtcagctt ttttcgctca tcaagctttt catacggagc aagcaggaca 2221561 aagactgtgt aaggcgcagg tgattgtata tatgattcaa gcgcactgac gttgtgctca 2221621 attttttctt ttttcttttc acctgttaaa aaatatggat ttttcacaat gacaagacgc 2221681 cgctccccca taaacggaaa cgtttcagca tctgcaatcg cttgatccag cgggtcctct 2221741 tccagatcaa aaacggacag attgaaatcc tttgtctcct gatcaacgac cgtctgtctg 2221801 atcctgctga cggtttcttg cagcagatat gtctcttttc cgtataaaca ataaaccgga 2221861 tggacctctc cttttttcag gcttttccac acatcaaata ccattgttgt acgacttcct 2221921 ctctttcatc atccccttct atcctaaatt gagtttgcaa aatagtaaag aggaagcctg 2221981 actgctgctt ccccatttat attaaacgcc tgttcgcaag cccccgggac agcttgtaaa 2222041 aaggcgataa tcaccagaac agaaaacgtt accttagctt ctagattttt caaaacaatt 2222101 ccattatact taagtcagtc aggagggata aagttgaatg attttgaaaa aaacgttcaa 2222161 agcaaacgaa atgatgctgt agattcagct gttggttttg ttgtgtcctt cggatttttc 2222221 gccttcttgt ttgtcatggc aacggttatt cacctagttg gttcataaca gcgactgccc 2222281 gggctgctga tttctcggca gtctttttta gttcgtctct gttatatctg atgtatcata 2222341 tggaggatag acagaaaagg ttccaactct gtttttgtat ctatattgga tcgttccgtt 2222401 ttgatctgtt cgcagcacgc ggatagaatg tctctgtaat agttgcagaa ctttttgatg 2222461 aggatgatgg taccgattgt ttttcccggc tgagataatg gccgttttcg gctgaagctg 2222521 ttggatgaat tcttcaccgg tagagccttt gctcccatgg tgccccacct ttaacacatc 2222581 tgcttttata ttcggaaaca cgttcatcac ctcttgttcc ccttctttct ccagatcacc 2222641 cgtcaagatc cagctcatac cgcccgtctc catccacaga acgagagatg aattattttt 2222701 gcttgccgga tcaggtgctt ccggtgacag tacatggaac tgcaaatcct ttatttgcaa 2222761 cacatcgcct cgcttcacct cttcaattgc cactccctct tccctggctg cctgcagcac 2222821 tttctcatct ttaggttcag aaacgaaccc tttcggaatc acgaggcgct ttactttatg 2222881 atgcttcagc agaatctccg cctctccgat atgatcttgg tcagcgtgcg tcagaattaa 2222941 agcgtcaagc tgcttgattc ccttagcagt taaaaacgga atcagcacct tttcccccag 2223001 tgaaaacgga tgctgttttt cgcgccaagg ctctgacgag taagacaaag tgccgccggt 2223061 atcaattaag acacgacccc gctgatgcgg agcacctaca aacatgctgt caccctgtcc 2223121 aatatctatc atatccactt ctccttcgga actaagacac ggatatataa agagcagaaa 2223181 catcaccgtg cagcaaatgc ctccggttac catcaactgc gacaaggagc gtttttcaat 2223241 cgccataagc aataggatga tcgtgactgt gaataaaaaa agcaaaacag gtgcaggatg 2223301 tgcgatcata atcgtgaaca catcaacatc tgcaatgttt gtgattaacc tattgatcca 2223361 gcttatcaat aaatcaaacc agctgaaaaa caatctccca aacgaagcgg aaagacttaa 2223421 tagaagaaca cctgctacag ctcccggcaa aatacagaag gtataaaatg gtaccatcaa 2223481 catattcatc ggtacgctga tgatagaaaa ctgatgaaaa tgatatagga gaatcggaag 2223541 cgagcccagc tgagcgatga gtgatacaat tgtcagctgc cccaaggagg ttttaacctg 2223601 ctgaaaaata gaagaggata gaattaaaga aaaactgacg gcgaacgata gctgaaaacc 2223661 ggcttcaaag agatgataag gattgaagag cagaaggacg atgtacgaaa ggcaaattgc 2223721 agttgcagag cggacacgcc atttgacaag acttccagct aagtaaacac ccgacatgag 2223781 agcggcgcgt agcactgaag gagcagcgcc ggtcaacatc acatagagcg gcagaaataa 2223841 cagcaacaga attgacgcct tttctctagt tataccaagg cggatcatga tataaaacaa 2223901 acctgctgtc aaaatcccca cgtggagtcc tgatattgcc aagagatgga caacaccaag 2223961 cttttgatac gcggtaagca cttcatcctc cacgtaaaat ctgtcaccaa ctgtaagtgc 2224021 ctgtacaatc cctgtcgaat caggaggcag aaggctgttt gtgaatgata tgatatgttt 2224081 tctcaagctg agcaccttgt acttgaaatt ttcaggttcg ctgcagtttt ggatagacgt 2224141 gacagagtag ttccaatgaa tatgctgccg ataaagatac tcgttataat caaatgcacc 2224201 cggcacagtt gcgtgattcg gttcttccaa tgtaccagtc aactcacatg acattcctgg 2224261 ttctatgtat aacagctgtt ctttttcacc agcagactga atgcgatacg cagcagccca 2224321 tttttcctta tcaggtgtct caaccatcat agacatacgg tcgccgtcaa ttttgggaat 2224381 agtgtcaatc actgccttga attgataggt tccctgccga taggaagaga cattctgaga 2224441 atctgtgact gcatacagta caaaaaacaa tataaaagag aagaaacaaa caataataag 2224501 aaaagcgtgc ctcgttttga ttaaaatgat gaggagaaag aggatgaaaa gaaaaatagc 2224561 ggggaaataa gcggcggcag taattccagc cgttgccgaa gctgccgcca taggcaataa 2224621 taagcgcgaa ttacgcattc atcacacgta gctcgtgaaa agtgtattcg cctgttcatg 2224681 tatctttttc aattcttcct ccgctaaacc ggcatcagcc aatttcccta ttagacccgc 2224741 tacaaatgaa agcttttctc tgtttttcag atcaacgatc atttcatcga gttcaacctg 2224801 ttcaacagtt acacccgcct gttcaaataa ttcctgcgca tacggatgtg ttttgtaatc 2224861 ctcagcataa taaaccgttt tgataccagc ttgaataata gatttgcagc attgaatgca 2224921 cggataatgc gtcacataaa tctcggctcc atcagtcggc accccaaact tagagcattg 2224981 aagaatcgca ttcatttcag cgtgaatggt tcttgcgcaa tgatcatcta tcattaagca 2225041 tccttcatct gcacaatgta cgccgcccgc gattgaccca ttgtagcctc ctgctatcat 2225101 gcgtttgtct ctgactatag tagcgccgac agataatctc ggacatgtgc tgcgcagcgc 2225161 caataaatgg ctttgagcca taaagtattg attccatgaa attcgttcca cgttgttccc 2225221 tccaaatgtt gtgttgcctg acctttagtt tacctatcat aatgcatgac cgtcaaatca 2225281 ctttactgta atggaagact ttattttctc aaatgacttt tcacctattc ctgaaacctt 2225341 agtgatatct tcaattgttt ggaaacgacc gttttcctcc cggtatgcaa taatagcttc 2225401 agctttggat ggccccaccc ctgagatgcc ttgtaactcc tctaaggttg ctgtattgat 2225461 attcaccagc gctcccttcc ctccatcgct ttggacagac cctccgccac cttgctgcac 2225521 tgctgtttcc tctccctttt tcgggatgta caccactgtc ccgtcctgca gaatctccgc 2225581 caaatttact tgcgcttcgt ctgcttgttc actggtcccg cccgctttct caattgcctg 2225641 agatactctg tcccctgttc gcatttcata aacgccagga tgctgaacag cacctttgat 2225701 gtctatcaca attgtttcgt ttgactcgtc gttgtttgct tcctgcttta ccactgtatt 2225761 ttctgtctct gttggtacag cttgcttcac cggctcttta tttttccctg tggccagaaa 2225821 gatcataatc gctgtgaaaa cagccgcaga agccgctaaa ataattgctt tcttatgctg 2225881 attcaaccaa ttcatcgtgc atgttccccg ctttcgtcat attttatttt cataacacat 2225941 atggtttaga ggataatagc tcaaaggagg ggaaaccatt gaagataggc tttatcggca 2226001 caggaaatat gggtacgatc cttatcgaat catttattga atcaaaagcg gccgatccct 2226061 caaacatgac aatcacaaac cgcacaattg aaaaagcgtt gcacataaaa aaccgctaca 2226121 acagcataaa cgttaccgaa agtctcgaaa agctcgtttc tgaaaacgag atgattttta 2226181 tttgtgttaa gccgcttgat atatatcctt tactggcaag agcgttacct tatttaagaa 2226241 aagatcatat tctcatttca attacaagcc ccgttcaaac cgaacagctc gaacaatatg 2226301 tgccgtgtca agtggcgcga gtgatcccaa gtattacgaa cagagcgctg gcaggtgttt 2226361 ctctcgtcac tttcggcaca agctgcggcg aatctgcaaa agcgaaaatc aatgagctga 2226421 tgcagcatat ctctcatccg ctgcaaattg aaagtgacat cacgagggtt gcatcagaca 2226481 tcgtaagctg cggccccgct tttatgagct atctgattca gcggtttata gatgcagctg 2226541 tttcggaaac atcagtgtct aaacaggacg cgattttgat gtgtaaggaa atgcttgtcg 2226601 gaatgggaaa actgttagaa accgaattgt ataccctgcc tgcattacag gaaaaggttt 2226661 gcgttaaagg cggtgtaaca ggagaaggca ttaaagcgct ggaaagcggt gtgcaggata 2226721 tgtttcaccg ggtatttcaa aatactcata tgaagtacga ggaggatatt tccgcagtga 2226781 aaaagcagtt tcatgtgtag acgagtatgt catacgttcg tctgtactgc aaaagcataa 2226841 aaaagcattt taaaaaacca tcgttttagg aaacgatggt ttttgatttc tgcgccttga 2226901 aaaagaggcg ttctgattgt gctgatggct cggtatccgt aaaatcagct gtcacgcgat 2226961 ggagctgaaa gccgcagttc ttaagcattt cttcgtattc ttccaccggg aacgttcttt 2227021 gctcgtgtgt ctcatcaaaa cgatcatacg cttctccgtt ccacacaaaa aacgacatat 2227081 catgaatgac agaaagctcg tcacttccgg caaagctctg ccaaatatag ctgatatctt 2227141 cgtcctggtc agcaaatgtg ctatccggaa agacttccgc aattttaaaa gatgaatgaa 2227201 catcaaacag caggatgcct tcaggcttta atacccgaaa aacactttta aaggtttcga 2227261 tcacatcatt ttttgttttt aaataattta atgagtcaca gcatatcaca acagcgtcaa 2227321 attgaccgtc aaagccggta atctctctca tatcctgctg aagaaataaa ataggctggc 2227381 tactcgatac cttttgctgg gcgaaagaaa gcatctcttc gctgagatcg atgcctgtaa 2227441 cctcgaagcc tttttcggca agccggatgg agatttcccc cgtgccgcat gccagatcga 2227501 gaatacggcc tttttccggg agagatgctt caatccattt tgtccattga tcgtaaggcg 2227561 cgtgtgacat tagctcgtca tacacgcttg caaagccttg ataaatcatt gattcattcc 2227621 aaagtcaaga tctgcgagcg gagcgtctcc ccacagcttt tcaaggttgt agtagcttct 2227681 ttcatccttg tggaagacat ggacaactac atcgcctaga tcaacgagaa cccatcttgc 2227741 ttcatcaaag ccttccatct ttttgacttg aatgccgttt tcatcagctt gatccttgat 2227801 ttcacgggca atcgcctgta cctgtttatc tgaatttccg tggcagatca gaaaataatc 2227861 agcaaccaga gaaatacctt ccatatccag tgctaaaata tcctctgccc gtttatcatc 2227921 gcaagccgca gctgcgatct ttaaaatgga cttttggttc attcacaaat tcctcctgtt 2227981 cagctgccag acacaagcca gttatacgtt aaaaatgtgt ctggaaaaac cggttgattt 2228041 tttttcataa gaaaaaccat tgtattttta atggactgaa tcagcgcttg attcaaatct 2228101 gtctcagcaa gcttacgcac ctcatcgaca ccgggaaatg cccggtttgg ctcaatgtaa 2228161 tcggcaacgt aaatgacttt ttctaaaagt gtcatgccgg ggcggcctga ggtatgatac 2228221 ctaatggcgt caagaatgtc ttcatcttga acccctgcct ctctttggac caaataagcg 2228281 ccgaccggag cgtgccagag ctccggatta tgatccaata aatgcgcagg cattttttca 2228341 cgcgcaataa tttgtttcat ttcttctttc gggcggaatt tggcgtaatc atgaaagatt 2228401 gccgctattt ccgctttttt agaatcggct ccaaaacgct ccgcaagttc gatcgccgtg 2228461 ttcatcacgc caaccgtatg gatatatcgg tgttcggtca attgctgctt cacgcatgca 2228521 agtgcctcct cacgattcat ataaaccatt ctcctctaca tacttcttca ctttatcagg 2228581 gattaagtag tcagtgggct tcttgctttt aaaccgttcc cttatcatag ttgatgatac 2228641 ctcaaattcc ggaacgtctg caaagagaag cggataaggg gtttcaacat gaaaaccggg 2228701 gcgctttact ccaataaatt gaatgaggtt cagcagctcg tccagcttat accatttcgg 2228761 caaatattca atcatatcag cgccgataat aaagaacagc tgatcatttg gataacgctg 2228821 cttcagtaaa gaaacggtat caaaggtata tgatggccct tctctttcca tttcaacaag 2228881 ctccagctta aaggacggat tagattgaat tgcaagcttt agcatttcca cgcgatgaaa 2228941 gctgtcggta tagtcttcgt tctgtttatg cggcggaatt tgattaggca taaaccaaat 2229001 ttcatcaagc cccgcctggt acagcacctc attcgccatt aagaggtgac cattatgcgg 2229061 agggtcaaac gtgcctccga aaattccgat tttcttcatt tcaaccacct ttaaggaagc 2229121 tcgatttgtt tattttcctt tgattcctta tataacacaa tcgtattgcc gattgtctgc 2229181 accaattgag agcggcttcc ttttacaaga gcttccgcta catcgttttt atcctcttcg 2229241 caattctgaa gcacgctgac tttaatcagc tctctcgctt caagcgcctc agcaatttgt 2229301 ttaatcatgt tgtcgtttac tccgccttta cctacttgaa aaatcggcgt taaatgatgc 2229361 gcttttgaac gcaaaaaacg tttttgttta cctgttaaca ttctgttcct cctaattttc 2229421 ctattacaat agatctcatt ttttcaatat taggctcttg tccagtccac aattggaaag 2229481 acaatgctgc ctgttcaaca aacatgccca caccatcgag tgttttcaag cctttttggc 2229541 ttgcttcttt taaaagtgcc gtctgtattg gattatacac gatatcacat acgacggcac 2229601 tgctcgcggc acgctgtaat gaaagcggca catcgtccac gttcggatac atgcccacag 2229661 acgttgtatg gatgataaca tcatactgct caagacgttc ttctgcttct tttatgctta 2229721 atacttcttt attgtgaaac gagggagtag cttctgtaag ccgctttgct ttttctaacg 2229781 tccggttgca aatgtcaaat tttttcgggg tatttcggac aattgttgta aaaatggctc 2229841 tcgccgctcc gccagcgccg atcattaaga atgacagttc agagatgggc ttgtctaata 2229901 ccttcattaa tgacttcacg aagccttccc catcggtatt gtatccgaca agcttatctc 2229961 cctctcttct gaccgtgttt acggcaccga gcacttttgc actctcatca atatgatcca 2230021 aataatccat aatggaaacc ttgtgcggaa cagtcacatt gattccttgt acgcctagag 2230081 ctcttattcc ttttaccgca tcctccagat cattctcttc taccttgaag gcatgataat 2230141 gtccgtcaag cccgaggtct ttcaatgatg cgttatgaat atcaggtgac atagaatggc 2230201 caataggatt tccgataacc ccgtacagct ttttcataca cctctcccct tttcttaaat 2230261 taatgaacgc cgaacaaata catgaacgcc ttttggcgcg tatgcagtta cctttttatc 2230321 agcgtcatgg acagtaaccc agcctaaccc agagaaaacg atatctgtct ttttgtcttt 2230381 tatcgtaaac gtatgggcga ccaattcagg aaactcatcc atttcatctt tacccggagg 2230441 tgtgagcaat tcccctgcat gcttttcata aagcgcgtct gcattttcaa gttttgttct 2230501 atgaatcatc agctcattcg gcatatagca aataaaagga gatctttccc cagacacata 2230561 atcaaacctt gcaagtccgc caaaatacag tgtttgctga tcattaagct ggaatgtgcg 2230621 aggcttcagc tcctttttag gagataatat tttcaggtcc tttttattga cataatgcgc 2230681 catttgatgg ttgttgataa ttcccggtgt atcataaagc gatgaaccgt catccagcgg 2230741 gatttcaatc gcatcaaggg ttgtgccagg aaattgggat gttgtaataa tatcttcttc 2230801 acctgacact tctttaataa tccggttaat aaaggttgac tttcctacat ttgtacatcc 2230861 gacaacatag acgtcttttc cgttgcggta atgctcaatc gcgtcaatta cttctctgat 2230921 tccctggccg cgacccgcac tgaccaaaaa tacgtcaacc ggttttaagc caagctcttt 2230981 cgcttcacgc ttcatccatt ggatcagacg ctctcttttc agtgacttag gcaaaatatc 2231041 cgctttattg ccaactaata agatagggtt tccccccacc aagcgctgca gcccattaat 2231101 ccagctgccg ttaaaatcaa aaatatcaac aatttttacg accagagagt ccgtttctcc 2231161 aataccgtga agaatgttca aaaaatcatc atcagttaag gagacatctt gtatttcatt 2231221 atagtttttc agtctgaagc aacgctggca aatcacattt tctttcgtaa gcgatgcagg 2231281 cggcgcgtac cccaaacctg ttttgtcctc ggtttggatc gtaactccgc acccgataca 2231341 aacaaccttt tccatttctt actcctccca ctgaatgtgc ccttttcgtt tgagagcact 2231401 cagtattctg cgttcgacct ggcggttaaa gcgcgtaatg aatccgtcag aggaagcgac 2231461 tggcacgacc aaaatcgtat ggtagccgtt tcggtttccc ccgagtacat cggtcagcag 2231521 ctggtctccg atgacaacgc agtcctcttt tttcagctcc atattgcgca ccgctctatt 2231581 aaaggcttta cccatcggtt ttcttgcttt atagatgaat gggattccaa gcggttctga 2231641 gaaaagtttc actcttcttt cgttattatt agagacaatt gtcactttaa tgccgtgttc 2231701 cttcatttct tcaaaccact cgatcaatcg cggcgtcgcg ttcggcctgt cccattcaac 2231761 aagcgtatta tccaggtcag taataattcc ttttacattt cgttccttta atttctcagg 2231821 tgtaatatga aaaatatttt ttacaaactc gtcaggtaaa aaaaactttt ttaacaaaac 2231881 ccgcaccctt ccctttttct ttctttcaaa atgattgtcg aaaaaaatcg aacttgcgcc 2231941 taaagaaaaa ctgagcaaaa aaatttcgac aaaaattggg tttcttcacc aggtgtggat 2232001 aaatttacac acactatcca ctcttattac atcactcttt agacaaatta taaacacgat 2232061 actcacaagt tatccacttt ttggtgtgga taacagaacg attgttctta tatgcatttc 2232121 atggtagatt aaagataact tcaacctcag atgaatgcaa cttatcattg tatgcgttaa 2232181 aatcatgaat gattccaact tttaaggagg tgcctctccc attaattggg ttcctagcat 2232241 gagaaaactg tctgatgaat tactaataga atcttatttc aaagccaccg aaatgaattt 2232301 aaaccgtgac tttattgagt taattgaaaa cgaaataaaa agaagatcgc tcggacatat 2232361 tatttccgta tcttcttaat aggaatttgt ctattttttc cgggcgtatt tccttttttt 2232421 actcagatga ctgatattat atcactttgg ctgcgcgctt tactactatt ttcagcaaaa 2232481 aacaccccta aaaagaggtg ttttaaaggg ccggttatta tgctaaccag tatatgccgc 2232541 ccacaacaag gagaacaaca actaaaacaa caataaaagc gtatccatat gctctgcctg 2232601 cgccatacat gtgaagcgcc tccttaataa ggttttataa cagcctatgt aggagaaata 2232661 aatcggacta ggcggttgtc cggctcaacg ctgcaggatc tgcccatctt gtattccttc 2232721 atatacgatc cttgcccctt taggtgtcat atgatttcca gaaggatcta taagaccaga 2232781 ttggataagc gcttcatcag ttgcttttcc gccgtctgct tctataaaat gcttccagtt 2232841 atctacaaga gggacatcca ggcgcttcga cacatctctt gtaatatcgt tatatgagtt 2232901 gtgccatttc cttgctccgc cttttggttc aaaagcagct gcttgatatc tggaatagta 2232961 aaacaaatga tgcttcccat taccttctat aattgggata cacgtcatta agattggctt 2233021 gatcccgtgt tttctgcttt cttcaataaa ataaaccaga ttttctctaa aacgctgctt 2233081 cgacactctc ggtttcccct cagtcagtat ggcagcgtca ttggttccga acataataaa 2233141 caaatacttc ggtttttgat ccagcacatc tgtctgaaat cggagacggg catcctctgt 2233201 cgtctgtccg ccgattcccg cattgagtat atcaaggtta ccgcgctcag ctgtttttaa 2233261 tatattgacc cactgctgtg cttttggata atcgcgataa tcccaattag agccacgcgt 2233321 attactgtca ccaaatgcta caacgtcttc gtatcccctt ccctcgcatc ctgctgtaac 2233381 gaacagcaga aggaaaagga tgataaaatg tttcatcttt acacccccaa aagcctcact 2233441 ttaatgttat acctctgttt ctcttcgttc aatgaagagt ttttcgctat cactgttttt 2233501 tcctatagtt aacgtgtccc cctcagtgaa tatcattctg ctttcattgc ggcgcagctg 2233561 atgatttttt aaaattccct tctttccaat ctgaaaaaca cacaaaccaa agaaaagaaa 2233621 ataacctgaa tccgcactgg aaacaggtta tccgttaaat cctgcattta ctttaacttc 2233681 gatttaagct tggcctttgt ttttggccca taaatcccgt ctgcagttaa tccgttcatg 2233741 agttgaaaac gcttgacggc attcgctgtt ttcggtccgt aaactccatc tatgccattg 2233801 tttttggctc ccttatcagg gtaaaagtga agtacagcta aagccttttg cagctggaga 2233861 atgtttgtgc cctttcgata aggcgaagtg agctttataa ccccagacgg cagaggatat 2233921 gatggtgaag tttcttttgg aggtgtatcc gaggaagaaa ttccgtttag aaaagagttc 2233981 cagtggtcca agagtttccg cggacattct ttcccggacc actttttgtg gggaacaaca 2234041 cgatttaacg gaatattgtt ttccttcatc agctttctga tcagccactg ggcatttgat 2234101 gttgcttttt caaaatcgcc gtcagcattt tcacagattt caatcccgat cgatttgcgg 2234161 tttcctgtcc cgtttgtacc gtctcccgca tgccagccgt tttcatctat cgggagatgc 2234221 tgataaatga ctgaatcgtc aactgtaaaa tgccagcttt cggatgtgtt cgggtttttc 2234281 acaaacttgg cgtgcatttt cgcatcagcg cctttggctg tattcgctgt attatgcacc 2234341 gtaatataag caggcgccat cgcatagcca ggacgattat catttgatac cggtataaaa 2234401 tcctttttta tggttaccat ttctatccct ccctattaat aagaatgcag aaaacagaga 2234461 gatggacagc cttttttatg aggtaaaaaa gaattgtgtt cttaacctgg ttttcagttg 2234521 aacagctgaa atggcaccag ttatactaat ttagatgacg gaggttttga ctcctgacat 2234581 cacctaagtt gggagtgacc atagacatgt taaaaaaagt aataggtata cttgtgatta 2234641 tcgctatcat ttcagttggt ttttttcaga aagaagcttg gcttgatgca atcaaagcag 2234701 gagggatgtt ttccgtttta tttagtatgc tgctgattgc tgccgatgtt tttttcccaa 2234761 tagtgccgtt tgctttgatt gctgctttaa atggcgcagt gttcgggact gcaaatggaa 2234821 tttggattac actgaccggc tcaatgcttg gtacaatatt gctgtttttt ctcgccaggt 2234881 acagttttag agattgggcc agaaaaaaag ttcaggccta tcctgccata caaagctacg 2234941 aggcttcctt caacaaaaac gcttttaccg ctgttttatt aggaaggctg atacctgtca 2235001 taccttcact tgtaatgaac gtgatctgcg ggctgagcca ggttcgctgg catgtttttt 2235061 tctttgcgtc tttaataggg aaaatcccca atattgttgt tgtcactatt gcaggtgcca 2235121 atttcaccag caataaatta ttgtctatca gcatttacgg tacatatatt ctgatcatca 2235181 tgctggtcat ttataaaaag ttccctcatc ttctgaaggt gccaaaaaaa taaggaggct 2235241 tgttggcccc cttacttttt ttctgtcgca tggcctccaa attcatttcg aagcgcagca 2235301 accacctttc ctgtaaacgt atcgtctgtt aaagaacggt atctcatcat tagtgacatg 2235361 gcgatgaccg gcgttgccgt ctgcagatca agcgcggttt ccaccgtcca ttttccttca 2235421 cctgaggaat gcataatgcc cttgatctga tccagtttcg catccttagc gaaagctcgc 2235481 tcagtcagtc ccataagcca agaacgaatg acagaaccat gattccacac tctggcaacc 2235541 ttctcgtagt caaaatcaaa ttggctgttt tcaagcactt cgaatccttc accaatcgcg 2235601 gccatcattc catactcaat tccattatgg atcattttta aaaaatgtcc gcttcccgct 2235661 tcaccagcgt atagataacc attttcgacg gcagtatcac gaaaaagcgg ttccacaatc 2235721 tcccatgctt catgatcgcc ccccaccata aaacaggctc catgccgtgc gccttccatt 2235781 ccgcccgacg ttccggcatc gagataatgg atacccgctt ctttcatttg attgtagcgg 2235841 cgaattgatt ctttataatg agagtttcca gcttcgataa tcatatcgcc tttacttaat 2235901 aaaggtgata catcacgcaa aacagcatcg acaatgccat gcggtaccat aacccatagg 2235961 atgcgcggcg ggtgtaataa agaaatgaac tctttaagat ttgttgtccc ctcagccccg 2236021 tatgctttca gttcatcaac agccgcttga tttacatcat atccaaccac ttgatgattg 2236081 cggtcaatga attgctttcc tatgtttatg cccattttcc ctaagccgat taatccgatt 2236141 ttcatatctg ttcctcctga ttgtctaaaa agcctttact ctttatgttc cctatggatt 2236201 gtattgtgat acgcagaaaa caaatggggc ttacatcgtc tgcgcatgta aattttattt 2236261 ttcatgaccg acggcgcctg ccagttctat tactgaatct ctttatatcc ataattatcg 2236321 ctttatcctt gatttaccat cagtttaagt taaaatatgg gaaggaattc gattttttca 2236381 gtaaaaagaa ggtgacatgt tgcagaatca atctcatact cttattggag ttacgaaaac 2236441 cgctgtattc tttttatacg ctgcacttgc aatcatcggt tttgcaatcg ggtattttat 2236501 tccgcagatt gcgaaatggg cattatccct cccctggatc cctcttgaag gaccacttcg 2236561 gctcattacc tcttttcagg gatctacagc ttcatttatc actgctcttc tcggtatgtg 2236621 tgcggggatt tggttcgctc attctgttat tgcaatgctg ctgtctgtca aaattacaga 2236681 tcacacagtg gaattcatca aaggaaaaaa agtgcaaaca attcattccg atgacatcgc 2236741 tcttgtattt atggatcaca aacggcttgt cctcctggga acagccggat atgaattggt 2236801 acgggaagaa attgatgaaa aaccagtaaa cgttgagaag gcctttagac agcatcatta 2236861 cgaatgggca acagatggtg atccgtttaa agatcaattt cgccgatgga ttcctgatgc 2236921 accagaccta tcgcaaggcg cccatgcctt attaaaagct cgtcacaaag cactgcagga 2236981 cgaagaaaaa gacgatattg aagaattccg tctcgaactg gcacagctgg gcatcgttgt 2237041 acgggacgaa ggcacacgcc aatattggcg aaaagcagaa acctatcccc cgaaaattca 2237101 gctcggcgaa ggattgtaac aacagaggct caagaaagag cctcttcttt actactgcac 2237161 aataaacagc actctggtac cgtcaggata gctgctcatt tgattcccta cccacgagcc 2237221 ggcgccgcga ttatcagaag gcgtcacata tcggacatca gcccctgcac cgccttcctc 2237281 gcagaccgcc atcggccact catcccggtc atagcccggc ttggtcggga ttccctttaa 2237341 agattcctcc cgccttttgt ctgctccatc tctgtcaatg gtacaaatat ctggatgtcc 2237401 ctctgcaatc gcatccctaa tatgactgcc ggtttccgga taacgagaca gcggaaaata 2237461 taacactttg tcatacgaag atgcgccttg gatctgttgc ggaaccatta aacaaagaag 2237521 aactgctgca gcaagaaaca ggcctgccat ccattttttc atccccatcc ccccatacct 2237581 ttgttcattt caatgtatgg gcgcttgatg aagaatattt ttaacatttg aagttagtat 2237641 gctgcttacc aaagccggac tcccccgcga gaaatttccc ggtacagaca cagacagcct 2237701 cccggtcaca tacatttaca tataggcttt tgcctacata cttttgtgga ggtgacgatg 2237761 gtgacaggtg ttttcgcagc gctcggcttt gttgttaaag agcttgtctt tttagtatct 2237821 tacgtgaaaa acaatgcctt tccacaaccg ctctcaagca gcgaagaaaa aaaatactta 2237881 gagctcatgg ctaaagggga tgaacatgcc agaaacatgc tgattgagca taatcttcgc 2237941 ttggtcgccc atattgtgaa aaagttcgaa aatacaggtg aggatgcaga ggacttaatc 2238001 tccatcggaa cgatcgggct tattaaagga attgaaagct attccgctgg aaaagggaca 2238061 aagctggcga cgtatgcagc gaggtgtatt gaaaatgaga ttgtaattac aaaagggggg 2238121 tgcatacacc cctctttaat acgtttcaat atatatggtg tcagaatcca caatggtaac 2238181 ttctttcacg ataaagttaa caattgtttt tttatcttca agagttaagt tatctgcacc 2238241 gattgattga aaatagtcga tggctctttt tagagcattt tcacttgagc tcgtatcatc 2238301 taggactttc atttttgact ggatttcgtt acacttttca gtaagctgat tttgcttttt 2238361 ttgcagttca ataatttgtg ctttgatttc atctatgtct aaatcatcgt catcgcttag 2238421 gctgattagc gttaaaagac gcttgcggcc tttttttgtt ttctctatct ctttttcaat 2238481 aagttctaat tcatcagaca ggtgatttga ttgttcagcc tctttaaaag aaacatactt 2238541 ttgaggattt gtgatgaatt taaaaatttc accccataca tgccggttca atttattctc 2238601 agacatttct tttccgcagc cgcggtcctt tgcgccagaa taatttttcc ggcaagtata 2238661 tacatagtag tctttaccat gtgattttct tttcttccct gtcatggtat ttccgcattt 2238721 tccgcatcta accaaacccg ataacaagta attgtgaggg ctgatactca agtgttttct 2238781 tttactttga cctaagagtt cttgagcata atcccattgt tcagctggaa caattgctgg 2238841 aattgtcaca gtgatttgtt cttcttcagg ccttatttta attatagatt tgttccctgc 2238901 ctgctttgaa acataggaac cctctgtatc atatttatac tgtctatgtt cacccttata 2238961 ggaagagttc attaatattt gccgaacaac ctgcctgtgc catactttgg cgcctttttt 2239021 tgttttaacc cccatctgag ttaaatgtag agcaatacca tttactctgc cgaaaaaagg 2239081 gcttttatga tcggtgaaat agttaaaaat catccgaatg atttttgctt cctcttctaa 2239141 tatctcaaga gttcttttct ctttaacaaa tttatagcca tatagtttag aatctttaat 2239201 gatcatgcct tttttcattt tttgaagtcg gccgcttgat gtccgttctt tgattttggc 2239261 tttttcaaat tctgagattg ccccgcgcat tgcgaaaaac aattgacctt ctggagaatt 2239321 ggcgtattca ccatttacaa aaatcaaagg tatgtttcgc tttcgcaatt cgtcatcaat 2239381 gattagctga ttcattaatt tccgagaaag acggtcagga tcgtaacaaa tgacttgact 2239441 tataagtccc ttgcttgcat cctccctcaa gcgattcaaa gccggacgtt ctaaaagctc 2239501 tcctgaaaat ccttcatctg catacttcag cacatcttta gtccctgctt tctttataca 2239561 ggcctcgatt tggctgtcga tgctcgatcc cttgatcgct tgttcctcgg tcgataccct 2239621 tacatatatt gctatcaccc tgaatctcct tcctataaag ttttattaaa taatgatagc 2239681 aatcgttaat gcatttgtca gcttgcggtc cctcgatgat tatcactttc ataaaatgca 2239741 tcaccccttg ggtaatgcta tgtaacagct gtttgtccaa atgaggagat tttaaattaa 2239801 actatagtgt tattaaacgt ttcaatgaat atgcaaaaaa tttaaaaaaa gttgttgtga 2239861 cttttctaca ctcctttagg tcctcaatag aaaagatttt attttctatg cctcaacatt 2239921 cgcttattat agttttcaat gatttattat tatttgagag tacaatggag tagtgttttt 2239981 cattgttaga tagttaatga catttcactg gtgtcaagtt cgtatagcta gacattaata 2240041 aaaaaaggac acatataaat atgcatcctt taacaaaaga gtttatttat ttccctgttt 2240101 cagcaaattc cttcaaccta ttccctattt catcacgaac tctttggaaa aacgcccatt 2240161 tttcttcttc tgtcccttgt gctcttgccg gatcatcaaa accccaatgc tcacgtttta 2240221 catgtggagg cgtcatcggg catttatcag cagcatctcc acaaagcgta acaactaaat 2240281 cagcattgtt cagaatatca gaatcgatta tatctgacgt ttgattagag atatctatac 2240341 caacttcctt catcgcttta acagcattcg gatttaatcc atgtgcttct atccccgcgc 2240401 tatacacttt ccactcatca cctaaatatt gtttagccca tccttcagcc atttggctcc 2240461 ggcaagagtt ccctgtacat aaaaagtaaa tgattttatt ctccatatat tccacctcta 2240521 catcgagtga cttccaaagt attttcgttg aaaccataaa gcaaccttaa caagtgctat 2240581 catgactggc acttctacaa gcggaccaat tacggcggca aatgctgcac ccgaatgaat 2240641 tcgatatcaa gcttcgcact taaacacagc ggaatttata atatatgctt ggacagccgt 2240701 aaaagccgaa ctgaacaatg gtatgatttt gctcatgaat tttgccatat atatagacat 2240761 gaaggcgata aaaaaacaat gcctgcaact tggactgatt atttggattg gcagtccaat 2240821 tattttacat atcacttttg cattccaact tgcatgttgc gtaatatcaa ccttccgtac 2240881 atacaatcac atgcaattga aaatgtagct tggttattta aggtatcccc ttcattcgct 2240941 aagaaacgtt taagcattta ttacaggaaa ctgactcaac atttatttag tcaaactgtt 2241001 acgggaaatt tatgcccccc ctttttgtaa tgaataatga aatcctcatg catttgcgcg 2241061 cattgaaaaa aacaaaaaaa gacgtctccc ttcacgatcc gatcgggcag gataaggaag 2241121 ggaatgaaat aagcctgatt gacgttttga aatcagaaaa cgaagacgtg atagatacga 2241181 tccagctcaa tatggagctt gaaaaagtga aacaatacat tgacatttta gatgaccgtg 2241241 agaaggaagt gattgtcggg cggtttggac ttgatttgaa gaaggaaaaa acgcagcgag 2241301 agattgccaa agaactcggt atctcacgca gctatgtatc gcggattgaa aagcgggcgc 2241361 tgatgaagat gtttcatgag ttttatcggg cagagaagga aaagcggaag aaggcgaagg 2241421 ggaaataatg cagaagaagc cggatctcat actccggctt tctctatttg aaagagttat 2241481 gaaaatcatt tttttcatcg ctgataagct ctccgagaaa gacaggcagg atcgtaacaa 2241541 ataacttgac ttataatcct cccgcaggca ttcaaagccg gacgttctaa aagctctcct 2241601 gagaaaatcc ttagatcggt atacttcagt acatctttag tccctgcttt ctttatacag 2241661 gcctcgatct ggctgtcgat gctcgatccc ttgatcgctt gttccacgat atattgctat 2241721 caccctggat ctcctgccta taaagtttta ttaaataatg atagcaatcg ttcatgcatt 2241781 tgtcagtttg cagtccctcg atgattatta ccttcataaa atacatcacc ccttgggtaa 2241841 tgctgcgtaa tacctgtttg tcctaatgag gtgattttca atgagtatga aaacaaataa 2241901 aaaaaccgat ggtttgtacc atcgatctgt tttctatatc actaggccct caatatagta 2241961 aatctagctc attggttatg aaagcttatt ttcattacac actatatatt catttgttat 2242021 catttctata cgtttatatc aattatggta aaaaatggtt acaaaaaccc aataaacgtc 2242081 caacctaact ttttcatctt atttattaag aattttaacc tcttccttgt gaaataaaga 2242141 agcgattttc atctccaaac agttaatgct atttcatcgg gacatgtctg ttaaagtagc 2242201 caataaatac attcggatat ccacttacaa ccacgattca atttgatcca ctacagattt 2242261 ctgagctgac attaaacaga tagagttata aaaatctgta ccagttccct ttcacaatta 2242321 ggacatttcg gcggcgtttc ggcataatgc gaactaattt attaatgttc aacaacagaa 2242381 tttcgtctat tggcaataaa gaatccacaa atcattgcaa gaatggccat cgcccaccag 2242441 aacgttgaga tcgcctgatc atgatcgatg ataatcaaac gaatgacagc tgtgatgcca 2242501 atataaatga agtagcgaag cggaaaatga aagtctgatt tgaagtattt gataatcaaa 2242561 gcaatgaact caaagtacat gaagaatata agcagttctc caagcatctc ataatagctg 2242621 tccactttgt tgaacagtga cttgtatacg aatagcacaa tgtaccaagt ctcgctgatc 2242681 agaagtgcgc ttaaggctaa cgccagaaag aacagacaga cgttgagaag cgcttgtaac 2242741 aggtaaggca cctttttgaa tttgttagaa aatctcatca tgttgtctcc tatttcaata 2242801 tattcgtggt ttttattctc agcctacatc ttggtgttcc aaaatcgtag cacaatgtag 2242861 tacttagaat tcttttgtat actgtgaaac tgtccctgca tgcgggacat cattcgcgca 2242921 atgcttcttt caccgagtcc gttgctttcc ggtgttatat ctgcaagttt aatcgtattg 2242981 ctaacatgga tctcaaatat ctcttgatcc gatacaaacg tgatactgat tttttcttcc 2243041 ggatctgcgt atttcaataa gtttgacatc acattatcaa atacacgacc aagctcctcc 2243101 aaattcacgt taatataggt ttccggcagc tcgcctgaaa tatggacccg aaaatgctcc 2243161 tgatgaagga tagcaatctg atctgatatt agatcgtaga tcacttcttt cactgcaacg 2243221 gtctccagat cggcctcata ttccttgttc agcaggaaat acgcaaacag attgtcagac 2243281 aagcttttta attgcagtgc tttaccataa gcattggcta cataccgatc tttgctggca 2243341 cccgcttcgc ctccctcttt tttggcaaac tccagattca tgatcagcga cgtcagcggt 2243401 gtgcgcatat cgtgcgacat ttcggtaacc aggctgcggc tctcagcttg caattcctcg 2243461 atagctttaa gtttatccag gaaagctttc cgcagatcct caatgctctt tgcaatcatc 2243521 gctaattcat catgcccttt tatcgtcatc tcgtagtcca gttcgccccc ttcaagaata 2243581 tgaatctctt gatgaatcgt tttaaggtag cgaagacttt ggcgaattcc gaagagaaca 2243641 atgattaaaa agatgagggt tgccccgagc aaatccaatg caaaggccag atcataatat 2243701 cgggaagagt agaaaccgtc gataatgact cgtccttcac catcgctaaa cttgacagga 2243761 tgtgaatgat tttgagcgta ctgagtcagc ttttcctttc cataatccga ttcggaataa 2243821 atagaatcat attgcagctc ctgatccttg aatatggtga ggttaatgta attttctttt 2243881 ttgacccact cgccaaacgc ttttctatct gatgtagaca actcattttc tgaaacgtac 2243941 ttgctgaatt tttgaatgta tcttgctgac tcctcgtgat aatactcttc cgaactcaga 2244001 tatccctcga tcagatcatc tgtgatcttt tgcaacgtca gaaagatcac accactcaca 2244061 atcgcagcaa ccattatcag caaagccagt tttttggtta gcgtaaattt aagatgcgcc 2244121 aaatcgatat cctcttcccc attcagtttt tatataaacc ggacgtgccg gatcatcctc 2244181 aattttggag cgcagcttcc gtatatgcac catcaccgta ttgttggaac agtaaaagta 2244241 aggctgtccc cacacactct catatatatt ttgggcagaa aatattttgt tgcgtttgtt 2244301 catcagaagt ttcaggatac gatactccag atctgacaac ttgatttgct tctcctcttt 2244361 ccacacctca ttaaattctt cgctcactct tagtttgccc ccgataagaa atgtttcttc 2244421 ctgttccttc ttttcctgat agatagtata tctgcgtaat tgagcaatca ctctagcgtg 2244481 aagttcctct tccgagaatg gtttagtcat ataatcatcg ccgccggcga gtaatccctc 2244541 agttttatcg agtgtactcg atctggccgt cagaaacaga atcgggacgt tagaggattt 2244601 cctgatgtgc tgacatgttt caattcccga aatgcctggc atcataatat ccaaaataac 2244661 caaatcaagc gagtcattca caagttgcaa tgctcgcttt ccatccttgg ctcttagcac 2244721 ctcgtaacct gcacgtgtaa gggattcctc caaaagatca ccaatatcct catcatcctc 2244781 tacgactaat attcgatagg ccatgtctct ctcacctcat gattcttgtt gttatttctc 2244841 gtgtgtcctt actatatatc gttcatagta ataagtacgt tataagatac tacgtaaatc 2244901 ttaacaattt atgaaagctg atgctcgcca caaatttgtc acattttcta aaaaaaatga 2244961 tgactcttca taaattgtta agattcggtc tttatattta tccattgtaa ggctcaagtt 2245021 tttcagatcc gcactacaca ttgccgtgat aaatgggaaa ggagtattga tatgattgta 2245081 caaaaagaag gacgcgggca accggtgagt ctgcgggaac gggttcattt tctggacatc 2245141 gtacgaggat ttgccttgct tggcattatt attgtcaatt attttctgat cgtagattca 2245201 gtaaagggat tcgaaatggc ctccgatgac gtactgcata agctggtttc ctggtttgcc 2245261 gaagggaaat tcgttacgtt attctccttc ctgttcggag tcgggtttat gatctttatg 2245321 gatcgagccg cgcagaaggt agagagtccc aacaagctgt ttgcccgcag gttatctatc 2245381 ctgttgggat ttggcatttt gcacatcaca tttgtttggg tcggtgacat attggccttt 2245441 tacgccgtaa gtggcttcct gttactcgcc ttctataaac gcacggccaa aacggtgctt 2245501 agatggatta tcgcacttat cgtgtttcaa ttcctgactc ctgttttcac aatgttgtac 2245561 aatgtcatca atactgcagg gtcaaaaaac ccgaattttt cagagtttac tttgtttagc 2245621 cacagcagcc ttacctacat ggaatccatc agcactcggt ggacagatat ggtcacgatg 2245681 gctgccggct ctttctctat gatctattcc atgtttctca tgtttctgct gggcgtgtac 2245741 tttgttaaga tggaattttt caaagacatg gaagcgaaaa agcctatatg gaagcgtatc 2245801 tggatcatta gcacaatcgc ttttctaata acacaaagca gtatattact agacatgttt 2245861 aatctttctg agaatatgct gtggaaggac atttcctctg tcttgggtca aaatggcggc 2245921 ttaaccggaa gtatgtttta tatgagcact tttgcaatgc tgtttctata ccttcctcag 2245981 ctgcgaggcc ctatgatgat attcaccaaa gtcggacgga tgtcattgac ctgttatctg 2246041 cttcactcta tcattggaac agttctgttc ctcaggtacg gattcgggct tgcggatcat 2246101 attcaatccg ccggcacgtt catgttcagt ctggccgtgt acttcgttct tatgagcttt 2246161 agtacattgt ggttgaaacg gtttaggtac ggtccgatgg aattagtatg gcgcaagctg 2246221 acgtacggca aagtaaacgg gagtcccaaa gcaactccgc tgcattcgga aaaatctatt 2246281 cagaaataac ccccttgcac agattgcatg acttcaaatt agtgttgttg aatgaagcgg 2246341 gcattaaacg gacagatttg atatatggac tagttatttt tatatcattt aggcttcttt 2246401 gggctaataa atccaccaga gtttactcaa tgtgcattgc tcatgatcga atctaaattg 2246461 aatcttttac gcatgttcat agtcaaaggc gcctcattcg actatttttg taacttttcg 2246521 caggaaaaat tcgagaatga tgacaaatcc cgcatacgac acttaatacg gtagtgaaca 2246581 atagtaaatt agggttacat gcagcttgtt ttccaatgaa acaaagaaaa agaatcatac 2246641 aaaaagacag gagaaagctt ttgaagtatt ttaacgccaa atttaccgcg gaagaaagag 2246701 cgatggaatc acttttttgt gaaaaggcct cgcagagcag ctcgaatgtt ttactgaacg 2246761 actgaactct atattttagc aactgaggga gtgaacaatc atgaaaacta aaaatgaacc 2246821 aaaagttatt ctggaactag caaaggaatc tgatctgcca gaattccaaa aaaaattaca 2246881 agaagccttt gcgatcgccg tgattgaaac gttcggtgat tgcgaagatg ggccgattcc 2246941 atcggacaat gatgttcagg agtctttcaa tgctcccgga gcagtggtat atcatattct 2247001 tcaggatggt aagaatgtcg gtggtgcagt agtacgtatc aacagccaaa caaatcataa 2247061 ttcgctagat ttattctatg tatctccaga atatcacagc caagggattg gtctttctgc 2247121 ttggaaagcc attgaagcac agtatccgga tactgtgctt tgggaaaccg tgacacctta 2247181 tttcgaaaag cgaaatatca acttctatgt gaataagtgt ggatttcata tcgtagagtt 2247241 ctacaatgaa catcactcta atccgcatat gcatcgcaat ggacgtgaag atgacaagcc 2247301 cctactgaat gatgatgact ttttcagatt tgtaaagatt atgaaaaaaa aggactaaac 2247361 aattgaacac ggcgagatgc cgcagagagt tgctggtaac ttttttatat ttcattatca 2247421 gaggaaggta ataatgatgt ttaaaaggtg ttttgatccc tgtctcataa acaggggtca 2247481 aaacaccttt gaatcatcgg tttcttttct gacatatacc acgcccacta gtccctcaac 2247541 atagtaaaaa catatcatga gttacaaaag cttttattca aagcatatgt ttattttatt 2247601 tatacttatt ttcatcattt ttcagaattc tggacacaaa tcgggtacct attagaggcc 2247661 aaggaactct acatttcatt aagaaatacg tactcattgc cctgctttaa ttaattttaa 2247721 gccctcgcac tatgcccccc cctgaattaa gtatttgatg taactttgaa attaagttta 2247781 tgaaaatctg tcacaaaccc ttatttcata acacatcatt tgtttcagct tccctcgcga 2247841 ataccggatt aatgctcggc tttaagatag tcaaccaatc tctccgcact gttcttaaca 2247901 tcttcttttg aaagatgaag tgtcccatat tgtgtaaacg caggaagaaa acgcattcct 2247961 atatagttag cagtgacttg aaacggtctg ataagctcgc tgatcgtgat attatattct 2248021 ccgcctgctt gataatcaga ttcctgtgcg cctaaggaga tagctaagag tagttctttt 2248081 ccatgcaatt tagttcctcc agttccataa gcccagccat gtgttaacac atcatcttcc 2248141 cattgtttga gtaacgcggg actgctgtac caatacattg ggaactgaaa aacgatacgc 2248201 tcatgatcta acaggagctg ctgctctttt tctacatcaa tgataaaatt agggtattca 2248261 ccgtacaggt catgaaccgt aatgtctttc tcttgcttta aacgattcat ccaggttttg 2248321 ttgacaacag acgtttccaa attaggatgt ataacgataa ctaatgtttt cattagactg 2248381 attatccttt ctttgccaat tagttattat tttttacgat aatgaattga ttctaatttt 2248441 aaaatagcaa ctttatttac acctatttta tcctttttca tgaattcagg gcaactaatt 2248501 gggcaccaaa atcaatgatg acttaagaca ttgttttgta gaaatccgat atacagaata 2248561 atccattatt tagaaaattt ctaccttttc cctcaatccg agctcgctct tcatgcggat 2248621 ggcctatttt aaaggaataa ctgactatgt tcatcagtta ttcctttaaa atacgaaagt 2248681 ctacgatatt tccatatcga tccgcttcaa tgtgacagca cccctcaagc agctgtttta 2248741 attttccacg tccgcgttgt acccttgatt ttgctccgga gtaagaaatg ccgagctttt 2248801 cactcaactc tttttgtgat aacccctgga aatcagttaa ctcgagcgcc tctcgatact 2248861 tttcaggcaa ccgtttgatg gtcgatcgaa tacacacagt tgcttccttg gtgaaatttt 2248921 cttcctctgc actgtcatta aaatgtagaa catcaggcaa tatttcgctt gttttttttg 2248981 tacggtaaaa atcaataatc gtatttctag tgatccgata aatccagctg tcgatctttt 2249041 gttcatcgat cagatttggg agatgcactt gtattttcat aaatacgatt tgcaagaggt 2249101 catcaacgat agattgatcg ttaaccctat gtgaaatata tgtttttaac ggctgatgaa 2249161 attgatccca tagatcctct atattcattt gaaaaaacct cctataattt tgcgtctgct 2249221 ttacatttgc ttcgtctttt taatcgtaac aaagagcaaa caattgttga atcaattgta 2249281 ttgcagctgt tgccaaaaat aatgataaag gagaggtttg ttgtggagta tacctattta 2249341 gggagaacag gattgcgggt gagccgttta tgtttaggca cgatgaattt tggagttgat 2249401 acagacgaaa agactgcgtt ccgtatcatg gatgaagcac ttgataacgg cattcaattt 2249461 tttgatactg ccaatattta cggctggggc aaaaacgcag gattgacaga gagcatcatt 2249521 ggaaaatggt ttgcacaagg aggacagcgc cgcgagaaag ttgttctggc gacaaaagta 2249581 tatgaaccga tttctgatcc gaatgacgga ccaaatgata tgaggggctt gtctctatac 2249641 aaaatcagac gtcatctgga aggatcactg aagcggcttc agacagatca tatcgaattg 2249701 taccaaatgc atcatatcga taggcggaca ccgtgggatg agatatggga agcttttgag 2249761 actcaggttc gctccggcaa agtagactat attggatcca gtaattttgc aggctggcat 2249821 ttagttaaag cgcaagctga agctgaaaaa cggcgattca tgggactcgt cactgaacag 2249881 cataagtata gtttattaga acgaacagct gaaatggaag tgctgccggc tgcacgggat 2249941 cttggtttag gagtagtggc gtggagtccc cttgcaggag ggcttcttgg cgggaaggca 2250001 ttgaaaagca atgccggaac tcgtacagca aaaagagcag atttaattga aaaacatcgt 2250061 ttgcaactcg agaaattttc agatttatgc aaagaactag gagaaaaaga agcaaatgtg 2250121 gctttggcat gggtgctggc aaatccagtt ttaactgcgc cgatcatcgg accacgaacg 2250181 gttgagcagc tgcgtgatac gataaaagcc gttgaaatca gtctggataa ggagattctc 2250241 cgcatgttaa atgatatctt tcccggacct ggaggagaga cacctgaggc atacgcctgg 2250301 tgatacattc attactcaat actgacattt ttcttaaata tttatactga actatcatat 2250361 taagaaagac aagagcatgt ttgtctcttg tcttttccac atcgtgctga aaatgctggc 2250421 taaacatcga caaaaatgct gccgcttaaa aaagaaccct aaacaataga gtaactggaa 2250481 agacaactgg cttgatcagc ttgggacccc tttcagctgt atttaaatca atcaaactaa 2250541 tgattcattg gcagtctaaa tattattatt gtttctttac aaaatagtaa tagcccctgt 2250601 aatgattgct aacaacgtaa taactaatga tgtaattaca gcccacttaa cggcaaacct 2250661 ttgaaatgac cccaagtcca ttttaagcat gcttactagc aatactgttg acgcaaccaa 2250721 tggactcatc agatgaaccg gctgccccat tatagaagcc cttgcaattt ctactggttc 2250781 tataccatat gctgaggcag cttctgcaaa gataggtacc ataccaaagt aatatgcatc 2250841 atttgataaa acaaaagtaa acggaatact agtgagtgct acaataacgg ggaaaaaccc 2250901 tcccattgat gaggggatga tggatattaa tgatcctgct atggcatcca ccatctttgt 2250961 cccggataat ataccagcaa atactcctgc tgaaaatacc aataatacca cggttatggc 2251021 attaccagaa tgctcggcga ttcgctcctt ctgcattttt acattcggat aatttatagt 2251081 aagggcaaga acaaaaccaa ttaaaaataa aactgacgga tgcttagttc caagcacaat 2251141 aaacaccatg atacttataa cgaggaataa attaagatat attaagcgtg gccttttcaa 2251201 ttgttcgctc tccaaagtag cagccatata agattgagag ctgtcctttg ttatatgtct 2251261 aggctctaat tgaacgatgc ctattcgatt cctctctttc cttcccatta gaaaagccag 2251321 aaatatcaca caagcaatac ctccaagcat ggtcggaagt aatggcacaa agaaatctga 2251381 aggatccaaa cccagcactg aaatcgctct tgtagctggt ccgccccatg gagtcattcc 2251441 gctaacgata ctcaacgaca gcattgctaa tgtcgccata accatgggat tcataccaat 2251501 tcttttatac aaaggtaaca ttgctgagac tgttatcata taggttgttg taccgtcccc 2251561 atctaaagcg ataagcattg ccaagacggc agaccctatc gctattttca cagggtctcc 2251621 ctttactata gataaaattt tttctattag cggatcaaat aaacctgcat caattaaaat 2251681 tccgaaaaaa agaatagcaa acaatagcaa tgccgctgaa cttgcaactg tttgaattcc 2251741 ttctaaaatc atgtcgccaa tacccttacc aaaacctcca ataagagcaa aaacaatggg 2251801 agtgatggtc aaggcaacaa taggcgagac tttctttgtc attattaata ttgtaaaaac 2251861 agttaccatc gaaaaaccta aaatagtaag catattacac ctccaagaat gcgctttcaa 2251921 atgacttttg attaacatat cttatacggt gtaataagtt aaataaatat ttttttactg 2251981 tgtttcaaaa aaaattctat cataacttta aatggttacc atttgttcac cctttaaaaa 2252041 atcaatgaat gctttaacga gtttgattcc taatgatttt tgatcgtaca ttagccaagt 2252101 atctctcatt agaggcttac ccttagcatt atacagttcc attgtgtaca aatgatcaga 2252161 ttcctgcagg caaatttctg gtgctatgga gtaaccaaga ccatgcttta ccatctcttt 2252221 gcaagtctct tgtcgatcca cttccattgc aataatgggg gcttgtttta gattcgtatg 2252281 catccaatct tctataatcg tttttaaaga agcatccgtt ttatatttga taaaaggtaa 2252341 aaaaggaagt tgctctatcg ttattggttt ttttgagatg atatgtaatt tttcccgtgt 2252401 cagccgttcc tccacccctt tccagcgatg gcttcctctc agtataccga cttgtacaat 2252461 accagcatct aataatttca tgacatctgt gctccagcct gtttgtacac tatattggac 2252521 attaggatac atagtggaaa attcccttaa taacttaggg agcttatatt gagcgaaatt 2252581 gcttgatacc cccagcctta gatgtccttg cacctctttg cttagattag agatatgatc 2252641 tttggtatct tgaagttcct gtagcattct tcttgcataa gcaaccaagt gttctccttc 2252701 cgcagtaaag gtaattcctt tatgcctttt ggtgaataat tcaattccga aaatctcctc 2252761 aatctttttc aaccgataag tgatggaagg ctgtgatgta aataatcgtt ctgctgtttt 2252821 tgttacactt tgttcttcgt gaagaatttt caataaaatc caatctttct catccatttt 2252881 catcttcctt tctagtcctt ctttcacaat tataaaagtt tttttatcga atattaagaa 2252941 aacttatatt ttatttttat ttttttacct tctacactaa aaaacataaa aaatactacc 2253001 tttaagatga ggatgatgac gatggtcaag acgaatgtaa caatcatgag aggcggaaca 2253061 agcaaaggcg tttttttcca cgaatcagcc atgcctaaca ataaaaacga atgggagccc 2253121 tttttgcttg atgtcatggg aagtcctgat aaaagacaaa tagatggttt gggtggcggt 2253181 aattccctta ctagtaaagt ggcaataata aagaaagcat atacttcgga tattgatgtt 2253241 cactatactt tcggtcaagt cagcatttcg gaagaaaagg tggactttaa ggggaactgc 2253301 ggaaatatct ccgctgctgt tggtccattt gctattgaag aaggacttgt aaaagcgaaa 2253361 gaaccaatga ctgcggtaag gatcctgaat accaatacga ataaaatgat cattgcggaa 2253421 gtagaagtgg aagacggtca ggtcaaatat gacggagatg ttacgatatc tggagtacct 2253481 ggatctggat ctccaatcta tttaaacttt catgatgccg ctggttcagt taccggtcat 2253541 ttattgccta ctggaaatag ttcggagttt ttagatacaa gtcaaggcca aatagaggtg 2253601 tctattatcg actatgcaaa tccattagtt tttgtggaag cgagcagtat cggcctggat 2253661 ggaacggaac ttgcagaaga atttactgat ctacagttgg ctcaatttga agaattaaga 2253721 tccattgcgg cagagaaatg cggctttgcc agtcgatttt cagctacaaa gttatcgccg 2253781 gctgtcccca aactggctat agtagcaaaa ccagagaaat ataaagatag tacaggtgct 2253841 tggcattcaa gcgttgagat ggacttacac atcaggatga tgtccatgca aaagccacat 2253901 caagcactgg ctgtcactgg agcgatatgt acaacaagag ccctttcagt ggaaggtgca 2253961 atccctgcaa gaatagcaaa aaaccactct acaaaggttc ggctagctca ttcttctggt 2254021 attattgaaa caatggtgga gcccactggt ataaagatcg tccgtaccgc acgacgtatt 2254081 atggacggaa cagtttatac gcatggagac tatcaaatga tgtagatgga ctgtgcaaaa 2254141 agcctccccc ctttccatcg ttaatagatg gattgaatgc gccttcttgc acagatccat 2254201 tgtaatcttg catggcttta aaaaagcctc tatattgttt tttatgaaat cgccaaggtc 2254261 ctttcatgta tctgcctcaa gcatgacata atcattatag agaaaattga atacttttta 2254321 ctgcaaataa aaagatacca acatcattgg tatcttttag attgagttca tctgcagcgg 2254381 tttcttttcc tcactgctta tttgattaca aaattaccgt actcgtttga acgaacatga 2254441 atcggtccgt ttagattata gttgttctcc ttggcgatag agcgaagcac gtccacacgg 2254501 gcaactgatt ctctccattc gtcacgggtg tcatgattgg ccggattcat cagatcgtca 2254561 tagcgtacgt ccaagaattt attcaaccac ttcttctcgt ctattccgtc tttaggtgat 2254621 ccgcccgctt ttttgttcgt acgtttaatc aaggcataaa aagagtcagg gtcatcacca 2254681 tcgccatgct gaataaccgt atcgtacatc acagctcttg ccaatgctgt ttttagtccg 2254741 gcattatccg atcgtttcat ggcaggctga taatacaaat ggtcatttac tttgtcttga 2254801 gcggcgcgaa attccttatc atttgcaagc gacttccagg cagaagcgaa tcccttgaga 2254861 ttgcttgtat catcgctttc ttccttggcc agacggcgca attcaggcag atactttttc 2254921 agtttgttat tcggaactgc ctttgtgtat acttccacta cttccaatgc atccccggta 2254981 gccgttgtaa agcctgcccg tccgcatgta tagcctcgcc cgtcatccaa tcgctctaca 2255041 tatccatatt ggatctccgt tgtgccgttt tcaaagatac ttgtcagctg ttccgcccgg 2255101 cgcttttgat ctttattcag tcccgccgca aaaaccgttt cgctcatcat cagggtaaaa 2255161 aacatggtga aaacaagtaa tgagatcgct gcttttttcc aaaaatctgc tttttgcata 2255221 ctgattttca tttcacttcc cctttctaaa tattgtaaat acagactcag tatacatgaa 2255281 gaaactgccc tattgttgaa aatacatcaa tttgtcaata ttttgaatct aaagtaatat 2255341 agcttgaatc ttactctatt cattgccaat cagccttagc ccctctcact gggaaggtcc 2255401 cttgattttc atactgcttc aactttcatt aacaagatgc cataaggctt tactctattt 2255461 tataatggaa gtgatcatcg aaaatcgtta gggaggtgat gtaatggcaa gcaagatgag 2255521 aatgccagat tccgcaacgt cccatgcaaa gcctactatt gggaaggcga tactttgcat 2255581 ggggtagact ttctaaaaga tcgcccaagt aagcttttct gatatagtgg ctttgcacct 2255641 tatttgacat aaaaaaataa ggagctggca gaaatggcat atgtaaaagc aaccgctatt 2255701 ttacctgaaa agctgatatc ggaaattcaa aagtatgttc aaggaaaaac aatatatatc 2255761 cctaaacctg aatcctctca tcaaaaatgg ggtgcgtgtt caggaacaag aaagctgatc 2255821 gatgacagaa acgcttctat taaaaaagca tttaaaaacg gcaaaaccat tcatcaatta 2255881 tctgatgaat atcacctctc tattgaaaca ataaaaaaaa ttgtctactc taaataaaca 2255941 aaacggaagc actgataaaa aataatcagt gctttttata tggcgagttt gtttcttagt 2256001 tatttcctgc atatgatacc attggccaat tgtgtaaagt taagggagat gagaagaaag 2256061 gaaggtccta caaatgacga taaacaatgg aacgttgcaa gtacccggcg cgaacatcca 2256121 ctatcaggtg cgtggctctg gtccaatcat tcttttggtc cacggaggag gcggtgatgc 2256181 cgacaagttc catcatgttg ccaatcatct ggctaactgg tacacggttg ttacttatga 2256241 tcgccgcggc cattcccgca gcaatctcgc caatcagatt gagggttacc gtgtggaaac 2256301 acacagtgac gatgctcacc gtcttctagc caaaatcacc aataagccgg cctatgtatt 2256361 tggaagcagc tccggggctg ttatcgggct tgatctgtgc atacgccatc ccgaacaagt 2256421 acatgtcatg atcccacacg aaccaatctt attgcagctt ctgcatggaa atgagctgaa 2256481 acaagccgag caattcatgg aagaccttaa gaaaaatcat cgaagtgaag tcattaaatt 2256541 aatgtcaaga ttagagacag acgaacaatc aaaggctgtc ctgacaaagc ggcttctcgg 2256601 caattcaacg tatttcactg agtatgaaat tcaaggaatt ctcagctata cattagattt 2256661 cgaagcatta aaaactgtgt ttacatcttc accgatgaag atactcccag ctggcggaag 2256721 tgcttctcgg gagctttttc cttatcgttg cgcgaacgcc ctagcggaac aattggaaac 2256781 agaatgggtt gaattccccg gaaatcatac ggggtacaca atgtaccata aagaattttc 2256841 tgagaggtta cacgacatgt tagaaaaaga aaagaaacat acgtgttaag gattgattaa 2256901 aattttcaaa ataggacagg tgaaactaac tatggaattg gagaagattt cacgaagcgt 2256961 aaaaagaact tttcactaac gagaacgcaa tgtgagatgt ttaaccaaag tgatattagg 2257021 gatttcatcg aaaaataggt ttgtacatta cgttctccta ttgattattt cctatcttaa 2257081 ttccgtattt tataccatta gatacaactc taaagcggct cgttattttg tcctcaacaa 2257141 caaccagtgt ctaacatcat gaatctcttt tgaaaatcac cacaaatgca ggtatggaag 2257201 acttcatcgc agcaaaaacc ataccaacta ttgttgttgg tatggttcgt cctagatagg 2257261 cccttaagaa gagattctat tgtacggagt atttagctaa ttgcatttgt aaccgacagg 2257321 gccgtctgaa cctgtgtaca catatgtgtc agacacatat ccaatattca cgacaccccg 2257381 ggaatctttc cactggattt ggtcccagat attactcgtt ccatacttcc ctgtaacagt 2257441 cgttccataa gcgtaacaat aataaggaac acgggagcca ctcggaatgg aaagcataat 2257501 aggataattt gtaccaggac cgctgcgcat attgacaggc gcaccgctgc ttgttgagac 2257561 agtaaagtac tgaacggcaa gtgcctgact ggaaaaaatg aataaagatg caatcatcac 2257621 ggttaacata ctcagcattt tcagtttagt caatgtcatc cctctttctt caattccttc 2257681 attttaagaa acgatagaac ataggctacc agctgcattt aggaacaacc ggaccgtctg 2257741 agcctgtata catatatgta tcagagacaa atccaggaac gatctccccg ctggcaagcg 2257801 tccgctctgt gtaattccaa atattgctcg ttccatactt tccagttaca gttgtaccgg 2257861 ttttgtagca atagatcggg atgcgggttc cgctcggaat ggtcgttaca attccccaac 2257921 ttgtacctgg gccgctgcgc atgttgacag gagcaccgct gcttgttgaa accgtataat 2257981 actgagccgc aagtgcatgg ctagaaaaaa tgaacacaga tgcaatcatc accgttagca 2258041 tacttagcct ctttaactta ttcaccttat accctcccct tataaatgcc gtacgtttga 2258101 ctttcttaca tccagttaag gatttacttt cagataccat gccccctccc ctcccatata 2258161 tttatcaatg taccataaac tagatctttc aaaagtggaa ttattcctat gttttcgaca 2258221 attaaggata caaaataaat ggtagtcagg cttgatattg atggtgtgtt acatttggct 2258281 cttaatcatt tgtccagtcg gtaatcacga ttgacaatca ggaaaaagga catggatcaa 2258341 gcggcttcgt ttccaccaat taactcaatc agtgtactgc ttccttgtat ccacgcttct 2258401 tctcgattca tagatactcc acctttttca ccaatcaaaa acggacacca tacaaatcag 2258461 cgtaaatgct gcaagttcag tgtccgcaac ctattatgac tttgctttct tttaccaggg 2258521 cgtgtaaaaa tgattaggta cgttatcaaa cgttattcta tgattttgcg agtcaaaaaa 2258581 tcataacatt ttatatattt caatcagatt atgatctgga tctctgaagt gagcaactcg 2258641 ggcactccat tccttgcgat catgcggttt attctcacat ttaactcctt tttcgtgtaa 2258701 atcgtcatac gttttatcaa catcttctac cttaaactga agcaaaaatt ttgattgagc 2258761 ttctccttcc aaggactttt tttcctctcc aacgatttca gccatcgttt ctcgagataa 2258821 aagctctatt ttcgtttccc cattatcaaa gagtgcatat tccatttcat tctctaacca 2258881 acttattgga agtcctaatg aatctttata aaactcgacg cttttcttaa aatcattcac 2258941 caacagtcta atttgtaaca gcttcatatc gagtgcctcc tataaaacca tacttttact 2259001 ggtcatccaa tttaatgata ccaaagaaac ctgacagcac tatgtcaagt ttccatactt 2259061 cacccttatt tcagatttaa gtgcagttta gtccatgtca taagaacgag caaaaacagc 2259121 gattcttaaa acaaaaaatg ataccgagtg tattttctgt atgcttcaac ttcatttcgg 2259181 gaaatgtaac gttgataaaa ggaggttaca tcaatatgga tcatcaaaca ttggcagctc 2259241 atgaggctgt tgacttacat gaaatcgtga actttaaaac actttgtata gcgaaatcaa 2259301 agttaatgca agggcttgtg tttgaccaag aactgaagga cttgatggaa aaagatgtac 2259361 agcaatccat tcaagacctt actgaattac aagcggttta tgagcgtgcc tcatttcagg 2259421 cccctgtccc tcaaagccgc ccaacgccaa tcatcaattg aaagggaggt aagcctcttt 2259481 gaataatgat catttagacc ccattaattc gctgaatgtg cctgaactag cagacactac 2259541 attcgcgatg gattttctta tacgagctaa ggaaggcgta aggaatactg ctgtagcttt 2259601 gacagaaacc gcttcaccag atgtaagagc actgcttcgg aaacagctga tgcaaggaat 2259661 tgcgatgcac caagagatta cggaactgat gatcagcaaa aagtggttcc atccatatga 2259721 gctgagcgaa cagtataagc tggatcagct ctctgcaaaa aacacgatca tggtcggcaa 2259781 tatgaacctc tttcctgatg aaacaaatcg caaagggatg tttgaccgga cacctgatga 2259841 acactaacac tggaggtttt acagcatgaa ggcagtaacg tatcaaggca ttaaaaatgt 2259901 tgttgtcaaa gatgtccccg atccaaagat tgaaaaatcc gatgacatga ttatcaaagt 2259961 caccagtaca gccatttgcg gatcagattt acatttaatc catggattca ttccgaatat 2260021 gcaagaagac tatgtcatcg gccatgaacc gatgggaatc gtcgaagaag ttggttctgg 2260081 ggtgactaaa ctaaaaaagg gagatcgggt aattattccc tttaatatag catgcgggga 2260141 atgctttttt tgtaaaaacc agctggaaag ccaatgtgat cagtctaatg acaatgggga 2260201 aatgggtgct tatttcggct attcagggca aactggcggt tatccaggcg ggcaagctga 2260261 atatttaaga gtgccgtttg cgaattttac ccattttaaa atccctgaat cttgtgagga 2260321 acccgatgag aaattaagcg tgattgccga tgccatgacc accggctttt ggagtgtgga 2260381 taatgccggc gtaaaaaaag gcgatacagt tatcgttctc ggctgcggac cagtcggcct 2260441 gtttgctcaa aagttttgtt ggctaaaagg cgcaaaacgc gtcatagcag ttgactatgt 2260501 aaactatcgc ttacagcatg cgaaacgtac aaacaaagta gaaatcgtta attttgaaga 2260561 ccatgagaat acagggaatt atttaaagga aatcacgaaa ggcggagcgg atgtagtcat 2260621 tgacgctgtt gggatggatg gtaaaatgag cgatctcgag ttccttgcca gcggcttaaa 2260681 gcttcatggc ggaacgatga gtgcattggt cattgcttcc caagctgttc gcaaaggagg 2260741 aaccatacaa attacaggtg tgtatggagg cagatataac ggttttccgt taggagatat 2260801 tatgcagcga aacgtcaata tacgctctgg acaggctcca gtgatccact atatgccgta 2260861 catgtttgaa ctagtatcga caggcaaaat tgatccggga gatgttgtca gccatgtcct 2260921 gccgcttagt gaagccaagc atggctatga catttttgat tcaaaaatgg atgattgtat 2260981 caaagttgtg ttaaagcctt aaaaaacgga ggttacagaa atggaatacg ccttacacga 2261041 agtgcttgag gttcaggaaa tgactgcatt taagacactt tgtttgacga aatctaaaac 2261101 aatgaaagca ctggtatctg atccgaagct gaaagaaatc atgcagcaag atgttgatat 2261161 caccacacgc cagttgcagg aatttgcctc tattttatct aatgcaaagc aagaatgagg 2261221 agatgaataa atcatgaatc ctatcataga atatctgact ggcatgaatg ttctaacaga 2261281 ccaaatcatt gctatggact tattaatttc agcaaagaac ggagtcagaa attatgcgat 2261341 ggcagccact gaagccggaa cgcctgaagt aaaagaggtc cttatccgcc atttggaaga 2261401 agcactcgat atgcacgaac aactctcaag ctatatgatg gaaaaaggct ggtaccatcc 2261461 ttggaaccct gacgaacaag tcaagctgaa tttaaaaaat attgatacag ccattcaatt 2261521 gccaaccctt taacatacaa tgactgattt gctgaggaac agtattgatt ggccacaact 2261581 gttcctcagc ttcaaaatga gcactgtttg ttcgggtcct atgaccgtaa atagattaac 2261641 cgcttttctc catctgatct ccgataatgt ttgcaaattc tccaatccaa ataaggaatc 2261701 gtaaccacct ctttttatgc gatctcttga tggagaaaac aggccagaaa caaaatcctt 2261761 cgtttttgac ctgccctctt cacacgcaaa gaatgctacc ttctttgctc cactgatccg 2261821 tgaagacttt ccgttttagg cctgcttttg agctttgcct cattttcacg caatttccca 2261881 tcataatctt taatttttgt gtctaatctc ttaattgttt catcaatttc tttccgcttc 2261941 tctatcagcc gctgtcgttc gtcagccagg atattttttc gagcttctac cgtacggtca 2262001 ccttcggtaa ataatgttgt atattcaatt agcgcttcta tcgatagtcc cgcatttcgc 2262061 atgcatttaa tgaattcaat ccatttgata tcttcttcat catagtcgcg aatgccgctg 2262121 tcttttcgtt ttacaggcgg gattaatcct acacgttcgt aatatcggag tgttgcggct 2262181 gtcaggccaa actgctttgc cacctgagca atattcatga tcttcacctc tctatcctgt 2262241 atgttgtgaa ggtaacactt aaagttaact ttaagtcaag ctcaaaacaa gtggttagct 2262301 gctgaatctg ggtttatata ttcgggactt gccttaaagc acactttaaa ctctatactt 2262361 ctccatgcac taaaaacagt gtagttggag ggattgctga atggcaaata aacacactgc 2262421 cggaagagaa caattaggag aatttgcgcc aaagtttgct gaacttcatg atgatgttct 2262481 attcggtgac atttgggcaa gagaagaaga actttcatcc cgggatcgca gcatgattac 2262541 agtttctgca ttaattactg actgtttctc agcttataaa tcaggttcat tttaaatggt 2262601 ttttttaaaa aacccttgcc ttaaagcaga ctttaaggtt tatcgttatg ttgaagacac 2262661 cataaaacat aaataagtgc atgtttttat ttacaacact tatgatgaag aaaggatagg 2262721 ttcgtatgtg taatcaacat caaacccgtg tattaagcgt gtcacatgca aaagccaaat 2262781 ttgaacaaac gacgattgag cgaagaggat tacggccgca cgatgtctta atcgatatta 2262841 aattcagcgg catttgccat tcagacattc atagcgcttt tgatgaatgg ggcggtggca 2262901 tcttcccaat ggtgcctgga catgaaatag ccggtgttgt aacagccgtt ggaacaaaag 2262961 tcaccaagtt ggctgtcggg gaccgcgttg gtgtcggctg ttttgttgac tcttgcggag 2263021 aatgcgaata ctgtctcaac gcagaggaac aattctgcac gaagggtgtt gttcaaacgt 2263081 ataactcagt agactacgac ggaaacccca cttatggcgg gtacagccaa aaaatcgttg 2263141 tcactgacag atttgttgtt cgcataccag atcgtttgga aatggatgtt gccagtccgc 2263201 tgttgtgtgc aggtatcaca acgtattccc cgctgaaaca ctggaatgtt ggccctggta 2263261 aaaaggttgc gattgtaggc gtaggtggcc ttggacattt ggcaattcaa tttgcacatg 2263321 cgatgggtgc agaagtaacc gtcctgagcc gttccatgaa taagaaagag gaagctctgg 2263381 aactcggtgc aaatcattac tttgcaacaa gtgacccagc cacattcact gcattggccg 2263441 ggcgttttga cgtgatctta aatacggtat cggcaaatct cgatgtagat gcctatttat 2263501 caatgcttcg tatagacggg acacttgtaa gcgttggagc tcctgccaag ccggacacat 2263561 acagtgtgtt ttccctaatc atggggcgcc gcagcattgc aggttctcta gtcggcggaa 2263621 ttcaagaaac tcaagagatg ctggatttcg cagctgagca tggcatcgaa cctaaaatcg 2263681 aagtcatcgg agctgaccaa gtggacgagg catacgaacg tatcctccga agcgatgtcc 2263741 gttatcgatt tgtgattgat atttccacat tgtaataggt tagtccttat atgggctgcc 2263801 gcttttattg aaactcacga aaaatgatct ctttaagcaa atattttgaa ggccggtcaa 2263861 tcttcctgtt attctatgaa tagagagtta ttaggagggt tttttatgag caaaaaaatt 2263921 gcagttcttg ttacagacca attcgaagac atcgaatata caagtccggt aaaagcatac 2263981 gaagaagctg gctacagtgt tgtggctatc gatttggaag ccggcaaaga agttaccggt 2264041 aagcatggcg agaaagtaaa gattgacaaa gccatctctg atgtggatgc aagtgacttt 2264101 gatgcacttt taattcctgg gggattctct ccggatttgc ttcgtgcaga tgaccgtccg 2264161 ggtgaattcg caaaagcatt tgtcgaaaac aaaaaacctg ttttcgcaat ttgccacggc 2264221 ccgcaagtac tgattgatac ggatcttcta aaaggcaaag atatcacagg ctaccgcagc 2264281 atccgcaaag atttaatcaa tgccggtgca aactacaaag atgcagaagt agtcgtcagc 2264341 cacaacattg tcacaagcag aacacctgat gatttggaag catttaaccg cgaatcttta 2264401 aacttgttaa aataacaaga aggcacagac tgttcgggtc tgtgcctttt ttaaaattaa 2264461 gactccttcg ttacattctg aaagacagca gtcgcgtccc acacattcaa gccaaattgg 2264521 ccttctgaaa atacggaatc atgtgcatca atcacaagac gatcatctaa atagatttta 2264581 aagcgatcgc cctcggcctc tgttttcaga tgatactttt tattaacgtc tatcggtgtt 2264641 ttgtattcag caatgacaga agcagcaccg ttctcaaatt taaagaattt cactaggtca 2264701 tgcttcgcat ccacattggc aaggtaaccg tttttggcat ctttgtcaga gcgaaacatt 2264761 agtgctcctg cccctcttcc gtttccatcc ttaatggtga tatcagattc ataagtgaag 2264821 tctgacccgg atgctgaaga caagataaag gaatcgccgt ccgacctccc ttgtttcccc 2264881 tcaattgtgt ctgcccacgt gccatttaca gtcgtccagc cagtcatatt ggacataaaa 2264941 ggtgtcgttc cccatacctt ttttaaaggg tgtatcgtta aagattttac ctttacaccg 2265001 ccatttgcag catataattc aagccctttg cttgatcggt ctgggagaat aatatccgtt 2265061 atgacctgct ttccgtcatt cccaaatact tcaaccgagg agcggtcaac aaaaatgcgc 2265121 aacttaacct tcccatttac cggcttcaac ggggctgttt cttttccggt gttaaaggcc 2265181 ggattaaagg tgtcgttgcc tgactcgctc cggtcaacga acaatttggc gttccttcgg 2265241 tcatagccga ccttcgtaaa ttgattttca cctgttcgga ccttaaaacc aaattcagca 2265301 gctgaaccag ggcttacttt aaattctgca tttatttcat aggcatctcc agattgcccc 2265361 gctaacacat tatgacttgc aggcgatatg gtcagattct tccacttctt agaggttccg 2265421 cgaatggttt ccagctcttt caccggtgtt tggaccactc taaccccttc ggtaaacgct 2265481 ttcaatttta actctcttgg aatggacgtt gcacttctcc atggggatgt cggaacatca 2265541 ttcgcatatt gccaattgct catccaccct aaccatagcc ggcggctgtc tgtggatgga 2265601 atatcagacc aggatacagc cgcataaaag tctctgccgt aatccgtcca gagaactttg 2265661 tttggcgggt tttcattttt aaaatgagtt ccatcaaagt cccctacaaa atattgcatg 2265721 cctgatcctc ccgagaccgc tccgtttccg acactgacct gcatgaccca tttcttttga 2265781 ttcggattgc cgtctaccgg aagctcaaat aaatccgggc attcccatac tcccccgtgg 2265841 cttccttgat cctgtccaaa ttcacttgca tacgtccact gcttcagatt ttttgatgta 2265901 taaatgagga ttcggtcacc ggccgcaagc accatcaccc actttttttc tttctcatac 2265961 caaaagactt ttggatcgcg aaaatctttt ttacccgggt ttggaatgac agggttgcca 2266021 gcgtacttcg tccatgttct tcctttgtcg ttgctatagg caatactttg cacttgatgg 2266081 ccttcccgat cctgtgtata aatggccaca agcggcttct ctttgcctgt ttgaaaaccg 2266141 cttgtgttat ttttatctac aactgcgctt ccagaaaaga tcgtgccttt ttcatccgga 2266201 tacagcgcaa caggaaggtg ttcccatgta accaaatctt tgctgacggc atgcccccaa 2266261 tgcatgggcc cccactgaag cccgtatgga tggtattgat agaacaagtg atattcccca 2266321 gcataatata ccattccgtt tgggtcattc atccagtttg cctccggtgt gaagtgatat 2266381 tgaggacggt aatcctcatc atagtagctt gaatcggctg catctgccga aaatgccata 2266441 gtcaacagca gggtgaacat gatcatgact tgaatcagtc tctttttcat ttgttccttc 2266501 gctcctctct tcatgtttga acactttcaa aagagactgc tgcgcaagct ggtccgtttc 2266561 tggcaattct cctctgtttc actgttatcc gaatgattta tatatgaaaa gactgctgca 2266621 gtttctctct ctttccttca cacaccttat gctaagaatc cagcccaata cccgagaatc 2266681 ccgatgacaa agatgccgca aataatgaga agtggattca cccctttgcg aagcatccat 2266741 gccaccaata acgttaatcc gagaggcagc gcccccggca taatgctatc tagcacgttt 2266801 tgtaccgttt gaacatctac ttttccgctt tcatccttaa tcctggatac aacgattgga 2266861 atgttgatgg tggtccattt ggacacgaga gcccccataa caaataaccc gagaatcgaa 2266921 gcgccctctg taagcttttg aatgcgattc cccgctaaat cctgaagaat ctccattcct 2266981 ttcacatagc catactttaa tccgtaatat tttgtgctta atcttatggc attcagcaag 2267041 aaaaagaata gcaaaggacc ggcaatgttt cctcctaaag caagggaggc tcctagcgca 2267101 gctaagacag gacgaatcgt tccccaaaaa attggatcgc ctacgcccgc tattggtccc 2267161 atcaaaccga ttttcattcc gcttatcgct tttccgtcaa ttcctttatt gttcgccatt 2267221 tcttcttcca tggctgccgt cacgccaaat ataggcgctg tcagccacgg atgtgtatta 2267281 aaccattcca aatgccgctg taaggcttcg tttcttttcg ctccgggacc gtacaatttt 2267341 ttgatcgccg gtatcatgac ataacaatat cccattgcct gcacacgttc gaagttaaag 2267401 gaaccgagta aaaaatttga acgaataaac atgctgaaaa tttctttctt cgttaatcgt 2267461 ttttctttct ccattttttc ttccccctca tcgtttaggc atcaagatca tcatcatcgt 2267521 catcataaac agcaacactg ccactgtctg atgcggccgc gactgctccg tgagcgcttt 2267581 gtttttgcat cacctgctgg tataaaagcg ccagacagag accaagggct ccaaatccca 2267641 ctaagttaaa atcggtaaac gccgctaata agaaaccaat atagaaaaat ggctttaaat 2267701 aaggaatatt catcatattg atcaccatgg catacccgac aaccacaata atgcctccgc 2267761 ctatttgcag tccttttgta atgacatcag gaatatttcc caggaacgcc tgaacagcgc 2267821 tgacactaat taaagcaaca atcaatgtag gaatcatgac gcgcaaagct tgaaacacca 2267881 tcgcggtaat atgcataatt tcaattcctt ttatatttcc cgcttttgca tattgatcag 2267941 cgcggtggat gaaaaagaca gtgatcgtcc gaacaaaaat cgtcagcgcc tgacccgcag 2268001 ctgctaaagc aacagcgaca gcaatccctt cgccaattcc ttgatcagcg gtaataacta 2268061 aaatggttga gatgacagag gcgatcgctg tatcaggtgc catggcaagc ccgacgttca 2268121 tccagccgag cgccatcagc tccagtgtgc ctccaagaat aattcccgtt tttaagtccc 2268181 cgagcaccaa gccaaccaac gtacaggcca ctagcggccg gtgtgtctgc ccttcatcca 2268241 atacacttgc gattccggtg attgctgcaa tgattaacaa caaaataatt tgtaatgaag 2268301 acatattctc atccccttga ttattttgtt acgttccgta aaatctgtac aaaatcctca 2268361 ctggcatctg aaggcagctg cctcaattcc agtttcacgc ccttgtcact taatgtttca 2268421 aatgccttta tatcttgttc tgtgacactg actgattttg tgatttgcct gcgatgattt 2268481 tcaaaacgca ttcccccgac gtttacggtt ttgatcggta cacctgcttc tataagagat 2268541 acaatatcgg acggattttc aaacaagagc attgccgtta ccccttcgta gcgcggacta 2268601 tgaaatgctt ttgccatttt agaaaccgag acggcactcg cctttacatt tgaaggcgca 2268661 acagaaagga tcagcgtttt tctcatttcg tcctgagcaa tatcgtcgga gacaacgatg 2268721 attcggtcgg ctgcatggac ttttatccac cttgtcagga tttggccgtg aataaagcgg 2268781 tcatcaattc ttgctaacac aatgttcatc ataattcatc ctctcttgta tcttgattgg 2268841 ctgtttttac tttttctaaa tgttcactgc acacttgaaa gctttgctga ctcattgctt 2268901 ttaagttgtt cagcaaatct ttgagagcca gatgttctct caggcttaat acctccagca 2268961 gaatcggcag gtttacgccg gcagccatat ccattctttg atcctcagca ataaaggaag 2269021 ctgccgcgtt atatggcgtc cctccaaaaa tatcgactaa aaaaagcact tcatgttctt 2269081 ccgggatatc cttgagcgcc tgatgatatt tttcttgcag cgtttgtatt ccttcccctt 2269141 tgaaaaacgg cactgcaatc aggttatttt cttcaccgaa tatcatccct gaagactctt 2269201 ttaatgctat gggaaaatct ccatgaccgc tgataataac tgaaatcata tctattgctc 2269261 ctttcctgtt ttgtacatcc atatataatg caaggatcgt gccaacacag ttgtgttaag 2269321 cgttttcatt gttatttcag ccaatagcaa tttgttgttg aaacacttaa aacgaaaaaa 2269381 ataaacctgt attaaaatgg tgttccattt aatacaggtt catatgaaaa aactgttttt 2269441 aaaacagctg gccatgcact tcttcagcaa atatggcggc tataaataat ttttcatcat 2269501 cacttatgcg aagtccgagc ttttcttcat aaggggctaa tgttcgctct gtcacgtaca 2269561 ccatttcctt cagctgatca ttgatctctt cttcctctga gaaagcgatc ggattctgct 2269621 taattaccct ttcaaaggcg aaagccgtgt gcataatgac tttgatcaaa accgcattat 2269681 tgaaaatgac ccccagctca tcctgaacgg tttgcagcca ctccaataac atgtcgatca 2269741 catggtgggg attcaagaag acaaggtatt ttttcaggct atcctcgcaa agctccctga 2269801 caataatatt tgcttcgttc aatccattgc tcaaggagat gcttcctttt gtaatcgcct 2269861 gttgaatcag cttctctccc tccccttcaa ttaacacttc taaagataca tgcggagcat 2269921 tgattttagg gtctttcgtt ccgactgtcg caaggatttc atactctttt tcgatttctt 2269981 ttatgctgtt ggccagctta atcgatgata cggtcaatat gtgaatgggg gtatcggagg 2270041 ccttgtttac gatcgtggtt agaatgtctt ccagcttttt ggccgttccg ctacccgtcg 2270101 tgcagatgga taccaatgcc ttctttttgc cggatgccgc tggctgacgc tcccacaact 2270161 cgataaaatc cttcgtgacc gattgataga tcgcatgcaa atttaaattc aaatagttga 2270221 cctttctgac agcatccagc accattgaag tcgtaacatt gctgatcgtt ttaatagaaa 2270281 tgcctgtctt ttcctccagc ctgctttcca gcattgcaag cgaccccata tctaccagca 2270341 ttaaaacacc ttcaccttca tcaacctgtt tcattttttc tgctacgcat tcaagaatgt 2270401 ccgaaggtga aacagtaagc ggcatgtcaa ctgctgcaat cggcgtactc cctagcagtt 2270461 ctgtcgcgac ttcaaccatt gaactcgccg tgctgtttcc atgagctgcc acgataatac 2270521 cgactctttt gttctccttt aacgatttga tggaatgaat taacatcgtt aagtagatga 2270581 cttctatttc aggaatagcc actttaaaat attcctgaat tttatcttta aaaatcatcg 2270641 ccacccgata ttctttcaca tgggtatcac gaatttcatc tgtctcctgt gtattcaaaa 2270701 catcaatttg ctttcctcgc tttaaaaatg cgtcaatatg catactcaag aaataaataa 2270761 acttacggtc aaatgtgcaa tccagctcat gttcagctat ttcttttaac tgttttgtca 2270821 tttgaatcac atcgtcttca acgaatgtca gcaggttgtc tttttgaaaa gcttgatgat 2270881 gaaaaaaact tctgacatgc aaatggacat cagtcaagat gtactggtta atatcctttt 2270941 tggataaacc ttctttcata agcgttttca ctttttcctc aatcaaatga tataagttaa 2271001 atgagaggtc ttcgtcaatt tttgttgttt catcttctac aatcggagag ataatcgttg 2271061 taatattgac atattcagaa atggctttgc ttctttgcat gtttttgctg ctggacatcc 2271121 attcttgctt gatttcatca ggcagatcgc gaacagtcag ttcaataact tcatttctgt 2271181 caaggttatg caaaaatccg tgtgcgcaaa ctaactgaac atttgatttc agctgtccga 2271241 cattcccaaa tttcgcagag tgaataagcg cattatagac atcgatatgc acactcagat 2271301 tcttcttaat tcgctctgct tctttcccta ataaaaacgt cgtcagatcc actctttcat 2271361 taagcgatcg ttcttcaagc gaaggaatat gaatggtcat tgggattctt cgcaaaaacg 2271421 ttttcaatag tgcagaactc ggattttctg tagtcgcaca aataaacaat acgttcgatg 2271481 ttcgtttatg ttcagattct ccaagcctgt tataagaacc gctgtcaata aaataaaaca 2271541 gcatttcttg tccctcggga gggagacggt ggatttcatc cataaaaaga atgcccccat 2271601 tggcctgttc gactaaaccc gccttatcct cggcagcacc tgtaaatgaa ccttttttgt 2271661 gtccgaataa ttgagaaagc aataattgag ggttgttgta gtagtctgca cagttaaatg 2271721 taataaatgg tgcgccggcc ttcaatatgt cagagtaaat ggcaaactgg taaattcggt 2271781 tcgcaaaaag ggatttaccg gaaccagtcg gccctaggag gagcatatgc agaccgttcg 2271841 gcggataaaa gacagctgct tttgcctggg agatcgcttt cttcaaactc ccttttgccc 2271901 ctatcataag ctctagggga ttcgtggaaa tgtgttgatg attttgcttt gaatttccgg 2271961 aaaacgcctg aaggtctttc acttccatca tctctgtatc ccatttcttg ttgaataatt 2272021 tttctgctat ctcgactggg atgtatctta caggaaatgt tttaattttg atgacctttt 2272081 tggaccggac gagattgttc aattcaaagc tgacattgga ccgctccatt ttcagctgct 2272141 cggcaatctc ctttgctgaa ttcccttgta tttttaaaag atgatctaag gttgaatcat 2272201 gaaaattatg cttgagctga tggtatattt tatctattct tctcacgtct atcatccttt 2272261 gtccttatta gataagccat taacaagaat atttcgaaac tttatagtcc gcgttgagat 2272321 ttacacgttt aaaaaggtct ctatagcaga ttgacaaagc tggcttttat gcgtatatgt 2272381 ttacatgttg aatcatttgc acctcatatt agtatgatag atgctcagtt ctggagggcc 2272441 agtccccttc aaaagtaata atcagtaaac agtttatcat tctcggggaa tgtaatgatg 2272501 tcaaaataat caatgacaaa aaatgaatct tatagatcat gacaaattac ccaaatataa 2272561 ccccttaagt tcgttcacaa ctaaaaagac ggacactcta tgtgaccgcc acagtattac 2272621 aatttgcaaa acttcgtcat ttttgcaatc cacattggag gttaaggaat ctgtaagctt 2272681 aaaaacttta tctccgatcc tatcgatttg atccccctgc cggcctcaat catagtgggt 2272741 atgcaattat acaaatcgtt accgattaaa actagcctgt cagattgtcc aaatgacttt 2272801 cctgttttac tctgctattc aggtagaatc acgagtgaaa aatagagcca caagacatgt 2272861 aacagcactt aaaatagttt taaaatttaa aaataaaagt atctattctt ttaaatgtta 2272921 taatatccga taaaacttta ctcatctttt tattactgga ggaaaataaa attgataggc 2272981 aattctagca aagacaattt tggccagcaa cagaaattgt ctagaggcct taaaaacagg 2273041 catatacaat taatggcgat tggaggtgca atcggtacag gtttattttt aggttcaggt 2273101 aaatccatcc attttgcagg accatccatt ttatttgctt acttgatcac cggcgtattt 2273161 tgctttttca ttatgcgttc gctcggagaa ctgctcttat caaatgcggg ataccactct 2273221 tttgttgatt ttgtaaggga ctatttagga aacatggcag catttatcac tgggtggacc 2273281 tactggttct gttggatttc cctcgcgatg gctgatttaa cggcggtcgg catttatacg 2273341 caatattggc ttcccgatgt gcctcaatgg ctgccgggtc ttcttgcgct tattatcctg 2273401 ctgatcatga accttgccac cgttaaactt ttcggagaat tagaattttg gtttgcattg 2273461 atcaaagtca ttgccatact ggctctgatc gtaactggta ttctcctgat tgcgaaaggt 2273521 ttttccgcag cttccggccc tgccagcctc aacaaccttt ggagccacgg cggcatgttc 2273581 ccaaatggat ggcatgggtt tatcctatct ttccaaatgg tcgtcttcgc tttcgtgggt 2273641 attgaacttg ttggactgac agcaggtgaa acagaaaatc cccaaaaagt gatccctaaa 2273701 gccatcaatc aaattcctgt ccggatttta cttttttatg ttggcgcact tttcgtgatt 2273761 atgtgtatct atccttggaa tgtgttgaat ccaaacgaaa gcccatttgt tcaggtcttc 2273821 tctgcagtag gcatcgttgt ggctgccagt ttgatcaatt ttgttgtatt aacatcagcc 2273881 gcatcagctg caaatagcgc tttattcagc acaagccgaa tggtctattc acttgcaaag 2273941 gatcatcacg cacctggact attaaagaaa ttaacttctt ctaacgtgcc aagcaatgcg 2274001 ctgttctttt catccatcgc cattctgatt ggcgttagtc tgaattattt aatgcccgag 2274061 caagtcttca cgctgattac aagtgtttca acaatatgct tcatttttat ttggggcatc 2274121 acggtgattt gccatttgaa atatcgaaaa acaaggcagc atgaagcgaa agcaaacaaa 2274181 tttaaaatgc ctttttaccc attatccaac tatttaacac ttgcatttct cgcgttcatt 2274241 cttgtcatat tggcactggc gaatgataca cgtattgctt tgtttgtcac cccggtctgg 2274301 tttgttttat tgattatttt gtataaggtg caaacccgca gaggacataa ggtgaaataa 2274361 aaaaaagaca agggatactc actcccttgt ctttttatat gtgtcaaaca ctaaattaaa 2274421 ctttggtttc aaatttcatt cacttcattt aagtgttaac tcaaaccagt tttgatgccg 2274481 aaacctacta atattattcc ggtaattttt tgaaacactt tctggaactt cgagtttttc 2274541 atccattttt ttgcgtaatc aataatataa acaagaaaca ggaaccacaa caccgctaat 2274601 aaggttagga ttgaagctaa aatgatgagc tgctggttta tatttccgtt caaattgata 2274661 aattggggca tgattgtaac atacaccaaa acagttttag gattgagaat gttactgagt 2274721 gatccctgca taaaggaagt tttataataa cgtttcggag aacttgccat attttttgct 2274781 tgggattgca tgtcatctaa cgaaaacata cttttagcaa aaaaactttt tacacctaaa 2274841 taaattaagt atgccgctcc caaatatttg atcgttgtga aaagaatcac tgactttgcg 2274901 attaccactg ataatcctaa aatggcaatc accgtccaaa aggaaagtcc tgtcgccaat 2274961 ccgagaatgt tataacggcc ggctttcgga ccatacctaa gcgtattttt catcacaagc 2275021 atcgtatctg cccccggtat gataaccatc atggcagcga tcggtatgta tgcgagtaag 2275081 ctgtgcattg ttctctcccc ctttaaaaat cccctcaatc atatagtgac tacaaaagta 2275141 actacttata aaagtgtatc aatgcgtttg gaataaatca atatgatttg ttaaaatagc 2275201 gattactaag gcagcgattg ctctttatat tggaggatat atgaaagaaa atatgttaga 2275261 cattttaaaa aacctcaatt ttacagaata tgaatcgaaa gcgtatttag cattattgca 2275321 agaatcacct ttaacaggct atgccgttgc caaaaaatcc ggagtgcccc gttctaaaat 2275381 ttatgaagta ttggaaagtc ttgtcataag gggagatgtt tttgtcagtc atggaaatac 2275441 gcctcagtat gttccagtcc ccgcaaaaga actgattaaa aaccgccggc tcaaagcgga 2275501 agagcatttt gatcaggctg agaaatattt tgaaaagttc gagcagaccg caaatgaccg 2275561 ggaaaacatc tggaatatca ccggccgcag tgaaattctt gaaaaggtga aggcttgtat 2275621 cttatctgcc aaaaaaagaa tcctcttaga aatatggaaa gaggatttta aggagataga 2275681 agcagagctc aaacaggcgg cagaacaagg cgttattgtc accattattg cgtacggaga 2275741 catcgtatct gattttgcca atgtttacct tcatgatatg agcagtgaaa ttacagaaga 2275801 gtatgacgga cggtggcttg tctatagcgg agatgattca gaagtagtag cgggcattgt 2275861 ctcacttggc aacgacagcc gtgctgcatg gacgatgcat gtagggttag tcatgcctat 2275921 tactgaagtg atcattcatg atctgtacct catggaaatt ctgaaaaagc atagagagct 2275981 tttagaagag agcttcggga aaaatctcat ccagttgcgc cgtaaatttt ctattcactc 2276041 agatttcaaa aaacattatt tggaataatg tttgtcatct cttaccccaa aaacaaggct 2276101 tgtacaaaac aagccttgtt tttttatgca taaacccccc atgctgattt acttctctct 2276161 tttaaaaaat gtgattctgc gcaaactatt tttcagcctg ccgcgtctat cctaggtaac 2276221 agcctacgat atacgtatat tcaaaaagga gccctttatt gcaatgaaga aaaaacaaac 2276281 aacaaaagcg ttgcttgtca catgcataac tgaccataag caagatttct acaggttggc 2276341 tttcagttat gtgaaaaatc aagatgacgc attagatatt gttcaggaat ctataaaaaa 2276401 agcgctgagc tcagttgaaa cggtcaggaa ccctgagacg ataaaaagct ggttttataa 2276461 aattttagta cggacagcca ttgacttttt gcgcaaacaa aaaaagataa gagtgatgga 2276521 cgacgaaacg atagaatttt taagcaaagg aaaggaagac cattacaagg atactgatct 2276581 ccatgaagcg cttgacgaat tgccgtaccg ctataaaacc attattattt tacgtttttt 2276641 tgaagacctc aaattagaag aaattgcgga aattacagga gaaaacacga ataccgtcaa 2276701 aacgcgccta tacagagcat tgaagctgat gcgcattcag ttgacgaagg aggatctttc 2276761 ttaatggata agagattaca gcaattaaga gaagaatata aaaatgttca gattcctaaa 2276821 gaattggata tcattgttga aaaagccctt cagcaagaac caaaaaagaa aagaatcgtt 2276881 atgtggccga catcagcagc aatcgctgca gctattttat tcactgcgct tgttaatatc 2276941 aacccggacg ccgctcaggc tatgtcaaag atccctgtca tcggcaaaat cgtcaaagcg 2277001 atcaccttta ttgaaatcaa agaggaaaaa gaccaatcaa gcattgatgt caaaacacct 2277061 gctttgtccg ggctttctaa taaagagctt gaaaacagca ttaacgagaa atacttgaaa 2277121 gaaagccagc agctgtataa agagtttata cagtccacat ccaaaaacaa aaaagggcat 2277181 ctcagcatct acagtgatta cgagacggtc acagacacgc cagatttact ctctatccgg 2277241 cgcaatattg aaacaacaca agcatcttcc tacacacaaa gccgttatat tacaattgac 2277301 aaaaagaatg atattttact tacattaaaa agcttattca aagatgagcg ctatatcaaa 2277361 gtcatcagtc aaaacatcaa agaacaaatg aaacagcaaa tgaaggaaga tccaaataaa 2277421 atatattggc tcactgacga agatgcagaa ccgttcaaaa cgattcttcc tgatcagacg 2277481 ttttacatta ctgaagacca taaacttgtg atctcatttg acgaatatga agtcgccccc 2277541 ggctatatgg gcgttacaga gtttacaatt ccaaccggcg tcatttcaaa cttgctcgtg 2277601 ggagaacgtt atattcgata aaataaaaac atccatctaa gattatggat gttttctctc 2277661 ttctctattc gaggtcgtaa ccccgctatc aaaaacaacg agaatatttg catactattg 2277721 gaggaatacc catgtatcac aagacacagc atcatcgata cattcctgga cttgatggcc 2277781 ttcgggcttt cgccgtcctg tcagttatca cttatcacct aaatttcaat tgggctaacg 2277841 gtggttttat cggggttgat atcttttttg ttttatccgg atatttgatt acatctattc 2277901 tattaccggc atatggaaat gatatcaatc ttgattttcg ggatttttgg gtgcgccgca 2277961 ttcggcggct tctcccggca gcgtacctta tgatcttttc cactgttgtg tgggtcgtat 2278021 tgtttgatcg agaactattg cacactgtac gtggagatgc gatctcttct ctcttttata 2278081 tgagcaattg gtggtttatt tttcacaagc tatcatattt tgatagtttc ggttccccat 2278141 cacctctaaa aaacctttgg tcgctggcga ttgaagaaca attttatatc atatggccga 2278201 tgtttttagt tgttggaatg tacataatga aaagccgcgc cagattggct gcggtgatat 2278261 cattgcttgt gctttgttca gccgtgatga tgagcgtact gtatgaacct ggcggagatc 2278321 cgagccgcgt ttactatggc acagacactc gttcgtttga acttctcatc ggatgtgcct 2278381 tggctttggt atggccgatg aaaaggctgt cttccaacag gctgccaagc aaactgaagc 2278441 acactttgca cgccactgaa tttttggcat tttgtatttt agtgttgtgt gtctatttca 2278501 cagatgaata cgagcctttt ctttacagag gcggaatgct attcattagc gtgactgccg 2278561 caatccttat tgcatgtgtt tgccatccga gcagcttttt aggcaatctg ctttcatgga 2278621 ggccgcttcg gtggcttgga acgaggtctt acggaattta tctttggcac taccctgtta 2278681 ttgtgttaag cacgccagtt caagaaatcg gaaaccctgt tttttggcat atcgtgctaa 2278741 aggtcattgt gacatgtata cttgccgagc tctcctacca ttttattgag aagccgatac 2278801 ggacacaggg atttaggtca ttttcccgcc gtgtttttat acatagaatc aaggaatgga 2278861 aaacgacatc tgtcatcagc aaaatgtcaa ttggtttcat tattttcgct atacttattt 2278921 ttgcaggcgg gctgtcaggg ctagccggcg agcaaaagca ccctaccaaa tggacctata 2278981 gctcacaaga aacaaatgct gacaccagcc aggcttctgg ggataaaaag aacgctgcag 2279041 cagataaaaa acacaatcct gaacaaaaga caacagattc caatcagggt caaaaggaaa 2279101 acaaagatag tgggcaagag actcataaaa agaaagacac gcaatcccaa cagttgaaaa 2279161 aaccagcaga cactgcgaaa gaagttttag ctataggaga ttccgtcatg cttgatattt 2279221 cttcacacct gcgtcagtca ttttcaaatg tgacgattga tggaaaggta gggagacaaa 2279281 tgtctcaagc tttggaactc gcaagggaat acaagtcttt taatcagccg aacaaggctg 2279341 tcatcattga gcttggaacc aatggctatt ttacaaacag ccaaatcgaa caactgcttc 2279401 aatctttctc aaaagctcat atttatcttg tcaatacacg ggttccccgc caatgggaaa 2279461 gcaaggtaaa tgaatctttg cagcaacagg cccacgcaca tcaaaatgtt acgttagttg 2279521 actggcatac agaagctctt cagcatccgg aatattttac ccctgatggt gttcacttgg 2279581 ttcctaaagg ggcaaaaact ttgactgctc ttattgttca ggcgatgaaa tcgtaaaaaa 2279641 gagatcctat acagatcact tttttacttt agtttctgat cgttgattat gtcttctttc 2279701 agcaaggcag cccttatgtt tacatgccgt ttacgtaagg gtaagccaaa attgaatgga 2279761 gggatgataa tgaaaggaaa tgaagaacat gacatccaaa aagagttgaa acgatatgag 2279821 ctttttttca aaaaacgata taaggttctt tatacagtaa acgattttat catcggtgct 2279881 atgtttctcg ttggaagttt tttctttttt tatgaccggt taatgtcggc agggatatgg 2279941 ctgtttgcga tcggaagttt gctgctgtta atcaggccga ccattcggct gattcatgac 2280001 tttcattacc gtaagcatgt ggaacagcaa ttcaagcatc aatcttcaac agatgactga 2280061 tcttaaggaa taagaaagaa caaaatgcca aaagcctgag tcgaaaatca aaaacaagac 2280121 tttcagacta tttattttta aaaacaaggt aaaaagaact aaacttttgc ctctgcatgc 2280181 cgatatgaat aataaggccg gcgcgatact ccctataaca tccttttcag tagatttcat 2280241 tatcgtgccg gttttctcat atgcaaagca atcccgccaa tcagattggc gggattttat 2280301 attttacatt cctgtccaaa cgtctttcac ataacgtctt tgatcttgca gcttttgcag 2280361 ccatacagct gattcttcct gacttgctgc tttttcagct tcatatgcca atcgcaaagt 2280421 tctctctaca tcaggagcca tttgcgatcc atcaccgcat acgtaaatat gagccccttt 2280481 ttcaatgagt gtcatcaatt tctgcgtatc ttgcttgagc aagtgctgga catatccttt 2280541 tggttcgttt tcgacgcgcg agtagcatcg gcggattgtg accaaaccgt cctgttccgc 2280601 ttgatccagc tcttctctgt aaaggtcgtc atggtccggg cggcggcagc cgaagtataa 2280661 aagtgcttca ccaagggtgc ttccttcctt cttcaaaacc gatcttgcct gaataaagcc 2280721 tctgaatggc gcaattcctg tgcccggccc gaccataatc ataggcgttt caggatcatt 2280781 cggcatctga aatccggact gcggcgtacg aatgaagcaa gctgctgcat cacctgtatt 2280841 caattctgct aaataattag aggcgacacc ccggtattca cctcggccgc tccatgctga 2280901 ggctttcaca actcctaccg tcatgctcac gatatttgca tgaactttcg gtgagcttga 2280961 aatggaatag tatctcggtt ttagtgatgg caaaagtgct aaaaaccgtt caaacggcat 2281021 ttcgcaagca ggataatcct ctaaaaaatc aagcatggta agacgttttg caagtacctg 2281081 ctctttgtaa atgccatcat ctgaaacgag ctgttccagc tctttttgat gcggcggaca 2281141 aactgtataa gaggccagct cccgaagctg aagccttgat gccggttcct gcagctctac 2281201 ataggacgac aataaatcca ctactttgat tggccgatcc atcggcagat gagccatatg 2281261 agcgcttccg cttactttta tcacatgatt ggactgcaaa ccgaatcggc tgagaacccg 2281321 ctgaacaagc tccctgctgt tctttggcag gattccgata tgatcgcctt ctttatatgt 2281381 tttaccagcc ggaatttcca attcaatatg gcgggttgaa cgcgtgctgg cagctgtctg 2281441 gagttctcga ttctctaaca caatcccttc aaacgcgcca tatgctttag caaccggcgt 2281501 ttccgtcgct tcactgagaa aagtaatcga taatgaaggc ctgtcttctt tctgggctat 2281561 ttcgttaata tcaaatgcgt ccatcgtttc cttccagaag cggttttccc aagactcgcg 2281621 gtggctttca aaatcatcgg cggcgtcacc ttccccaatc gctgttaaac gcgatgcccc 2281681 ctttgctttc atcatgtcat caatcaggcg gggaatccgc tgatacgtgc tggcccagct 2281741 ccggtttccg cagccgaata ccgcatagga aacacctttc aattggcctt cctcaagctc 2281801 tttcagccac tctacaaatc cggcagcatt atcaggcggc gccccattat aagaagccgt 2281861 tacaatgacg actgcccctt cttcagggag cttgccgata taatcatcaa gcggagccgt 2281921 ttcagctgta aagcccatct ggcggccttg agcagccagt tcaccggcta ttccctcagc 2281981 tgtcccaaga tttgaaccaa aaagaacaag taaaggtgtg ccgtgtttag gtttggtttc 2282041 ttttggcttt gtttctgctt tgatgtctgc ctgttctttt ctctgtacat tgattgccgc 2282101 tgtttttcgc ggtttcacag taattttaaa atcatccggc ttgatcgtta atgcttcttt 2282161 gatttttagt tcgtagccag tatggtttat caattcaaaa tgctttaata caagaccgag 2282221 aaccattgtc gcttcttgaa gagcaaactg catgccaata caagcgcgct gtccgtttcc 2282281 aaacggctta tacgcatggt gagggatact tgaaggatcc tcaaaccgtt ccggacggaa 2282341 atcttccgca tccggtcccc aagcgttttg atcccggtgc agttttggaa ttaaaacagt 2282401 gactggctgc cctttgctga tcggatattc cccgcctaga acagtatcct ccttcgcata 2282461 tagagaaaaa gccggagctg ttggatacag tctgagggtt tcatttaaaa ccatccgaat 2282521 gtatttgagc tgctggattt gtttatattc aggcgtgtca tccgttaaca cgcgatccgc 2282581 ttcctcctga gcttttttca gtttttccgg atgtgtaagc agacaataaa tcgcaaagga 2282641 tagcaacccg cttgttgtct catgtccagc aattaaaaat gtgatgattt ggtatcgaat 2282701 gttttcgtca tccagcgttt cacccgttac tggatctttg gcataaagca tgagagacaa 2282761 gagatcctta atgttttcat ccggattcgc ctttcgctcc gctatcattc tatcaaccag 2282821 ggagttcatg acttctatat ccttttggaa ctgcagcttc gttttcacca tcattttatc 2282881 ttgcaggccc agtcttttcg attgattcat cgcctctttt aaggcacgga gcatactggt 2282941 gataaacgga tgctgtgaat cacggtaaaa gctgttgaat cgatagttaa acccgcataa 2283001 cccaatcgta tcaagcgtca gacgtgtcat atcgtccgct acatcaattt cttcattagg 2283061 gtttaaccgg ctccactttt gaatcagctg ggttgcgata tccagcatca tagaatgata 2283121 gcctttcatc gctttttgac taaaactcgg cagcaaaatg cggtgggctt tttgccagtt 2283181 cggttcgtgc gtccagcttg taaataagcc atctcccccg aactcacgca ccttttgcaa 2283241 gcctttgcca aggttcttgt caaagcgttt ttcatcacac acttcagcca caagattgtg 2283301 gccggacaca aaaacactgg atactcccgg aaaatcaaaa cggaaaatcg gtcccaattc 2283361 atcagctatc cgccataagg attgagaaag ctgttctttt tccagatgcg gaagattttt 2283421 taaaggtccg tatgttttgg gctgaggtat tgcgcttgcc tgtttcatta acatctccct 2283481 ttcctatttt tgtgatgaat gaagcttaat ggcgtcccag cagcattgtt ccaattcagt 2283541 aattaaatca gtgtccatct ctatatcacc tgtttgaacg agctgatata tcttgagaaa 2283601 cgcccctaat acaatcgcaa ttaacacatt agagggcagg ctgcgaatca cgccttccgc 2283661 ttttccctta ttaaaatagt catcaagcat ttgagtcaga ttttctatca tttttttgct 2283721 tgtatgattt aagtaatgag cgtctttttt ggtttcaaga aaaaaaagcg catagtcgct 2283781 ctctttcgta aactgaacga gacagcaaaa tacgtggtga aagccttctc tgacaggcaa 2283841 ttctgaaacg tcttgcttca gtttttccgt aaatcgctgg atgctttctt gaaacagtac 2283901 gttaacgagt gtttctttgc tgtcaaaata acgatagatc gttcctgtcc ctacatgagc 2283961 acgttcagct atcataggaa tagtggtagc gtcaaaaccc ctttccgtaa aaagtgagac 2284021 tgacgctttc ataatcatgt cgtatttact gctggatgcg gatatcatgt aatctgacaa 2284081 cctccgattc gtttacggaa tgaatattca ttccttttgt tcacaaagaa tgtctgccct 2284141 gtctgatatc acctctttgt tctttcttct gttataagtt tatatgaaaa aaactttttt 2284201 taatataaag tatatgcaaa aaataaaaaa ttaagaaaat atacccaaat cctaatacga 2284261 ggatcttgga tatatttccc gagaaatttt ttatttaaca gccacaatac atagacagga 2284321 agcacgcctg ataacagaaa gatccctgaa atgctggtct ttcagcagtt gaatatacgt 2284381 tttctctttt tcaccggtat ttgtgtcaat actgatataa aaccggccgt caatttgaag 2284441 caccctgtaa atttctctta atgcaagcct aatatcggtg cagctttgaa ccgtatgtaa 2284501 agaaaagact ttattaaagg tacggtcatc aaagggaatg tcctctggat agccatgaaa 2284561 aacctccccg ttccccatgt tctttcgatt cgcacgtgat atctgtctta cctttcgttt 2284621 tgaaggatca atgcttttta ggctaccctt ttttagtttc ttggttatgc ttttaaagac 2284681 agtgccgttt ccaattccaa tttctaaaat tctgtcattt tcttgtatat ctatagagtc 2284741 aatcatcata tgctcaattg ttttggttag cttatatttc cgagaaaata atttccaaaa 2284801 atccgatcgt ttatagagtc tattttctag cattttaaac acctgctttt ggtttcctat 2284861 gtttatttat tatcttaaaa aaataaacat catcttcatt tctaaaagtg aaggaaggta 2284921 ccaactagac ggcaatgtat tgaaaaatgt ttcaatagaa ctaaactttt tcattttttt 2284981 ccgaaaaaaa agcagaaaac ataatgtttt ctgccctctt tctaatgcca atgataaggg 2285041 aatacataca gcctttgctg ctgcattgcc atcagcctct gctgtcggaa tggatttcca 2285101 taaccatgtt tgaaggaatg cggcatggac gcataaccat ggccaatcga cggcagtctt 2285161 ttttgataat cgttcatcat gccatcacct gcctcacaat aacgttgatt tactatatgc 2285221 aggcgcgcat tttcttgaca gctatttcgc taaacttggt ccttctccat tgtataatgc 2285281 atcaatagtt ccattctaag catatgccat tcccccttca gtttttttcg ttgcttttag 2285341 cgccagtttg ttaaataaag atgctttaac tgagactctt tcatttcatc ataaatttgt 2285401 tcaatctgct gttctcgttc gaattcttcc aggcttttaa accgtttttt aatcgttaac 2285461 gttaaaaaga ataggttaat cgtcatatcg ctcaccccct ttcaaagtcc gcatcaagcg 2285521 aaataacccg cggcacaacc cttctgccgc gggcaaataa aaaccgcaga caaaagaaga 2285581 caccaatgcc tctactgcct gcggggagtt gcgtatgtcc gactattccg aatttaatgc 2285641 gtgcgataag catcggttaa ggaaggacac gaactcttcc acaggctgaa taaaccatga 2285701 acttttacat gtgtatcacg tacaggttga cgtcgttgtc tcattgtcat tttggttcag 2285761 cctcctttgc ttttttctta ctttgtaagt atatccacca aattccattt tgtaaacatc 2285821 tttttctaaa aatggacgga aattgtgcaa atcatcgaat ggatttgccc gttggtcatg 2285881 acacctgctt catttctttt ctggagcggt ctttcttatg atatgcaata aaataaatga 2285941 gaccgacaaa tacagctccg ccgatgacat taccgataaa agccggaatg atgtttccga 2286001 tgaactgccc ccacgtgaat gagcctgcaa aaatggcagc aggaatcaca aacatgttgg 2286061 cgacaacgtg ctgaaatccg atagccacaa aagccatgat tgggaaccag atgccaagga 2286121 tttttcctgc tgcgtcttgg gcgccgaaag aaagccacac tgcaagacat acaagccagt 2286181 tacagccgat ggcggaaatg agaaccttgc caaagctcat atcaagcttt ccttgggcaa 2286241 cggcaatcgt tttttctaaa taaggacctg tttcagtcaa tccaaccaaa tgcccgaaaa 2286301 agtaagcaac aaacaatgcg ccgattaagt tcataattgt gacgattccc cagttaatcg 2286361 ctaactcttt tactgatatt tttctcgaaa ataacgccat cgcaactgac atcatattgc 2286421 ctgtgatcag ttcagcgcca gcgagaacga caaggatcag gccgactgga aatactgctg 2286481 caccaatcaa actggacagg ctcccccatt ctttcggaag atcgccaatt accctgatat 2286541 caagcaaata cccaagcgcg ataaatgcac cgcctaaaaa ccccagcaca agcagtgacg 2286601 gcagcgggag ctttattttt ttcatccctg cttcaattgc tgcttccgct atttcatccg 2286661 gttttcgaaa agccataata aaacgcctcc attacttctt cttttctcac agttatgcaa 2286721 gaaaggcaat aaaaaaggca gcactcaaat aacctgtgtc aaaccaggcg tttgaatgct 2286781 gcctaacttg tatgcatacc catacaacaa tatcaagcag tatataagat attgaaagag 2286841 aatatataca gttcgtgcat acattccatt gctttagcct tctataactg tagcaacatc 2286901 atatcaaatg tgacaaattt gtgtcaatga caaatatact agctttgcag agcttctttt 2286961 tgctcatcta tttttcggtc aaaaacaaat acagatacag cgatgttttc ctcaatttta 2287021 atatcagaaa acaaatggac tagcttagct cccataagtt cctccattcc ttccggtgtt 2287081 tgtttggaat aaaggtcttg aattaggctt gtccgggccg catgtaccat ctctcttcct 2287141 tcaggcgtgc gggcaataaa ctgctcgctt gcactcagat ttccgtatag tgttgaaact 2287201 gccatgtttt ctacaaatac agtatgaatt ctctcaggcc cttttccgaa caattctttg 2287261 cgaagttttc gaataatatc attgaattca tgaatttttt tagacatgct gattacccct 2287321 tccgatattg ccttataaag gcttttcccg gttcccctca ggacatttca cttggttaaa 2287381 attttcctgc catattgtat tataataaat atcacattat aataaaagca gtgttgatgg 2287441 atttgtaata ggatcttgtt atgagtctat cgttttataa aaatcaagga ttggtctgtt 2287501 agtaagactt gctagtgaac tattccgcca tgtgtgttta caccttctta gaattaaggg 2287561 caggtgtatc tatacatggc tttttttgac ttcttgaaag aaagatggag gggaatatga 2287621 atatgatgga cgttaagtcg atcagtgtcc gtgtagacgg aacagaaatt caagcacgag 2287681 caggggccac aattttagat attttaaatg aaaacggaat tgagtacccg cagatttgcc 2287741 acgtaccaga ggttgacccg attcaaactt gtgatacttg catagtagag gcaaacggca 2287801 agctggttcg ttcatgcgcg acggttgcag aaaacgggat gtctattgat ctttcaggaa 2287861 atcgagtgaa agaagcgcaa accgaagcga tggaccgcct tcttgaaaat catttgctgt 2287921 attgtacagt ttgcgataac aacaatggaa actgtacgct gcataataca gcggaaatga 2287981 tggggatcga gcatcaaaaa tacccataca cgccaaaaga agatccttct tgcgcggttg 2288041 atatgtctca tcctttttac cgctatgatc caaaccaatg tattgcctgc ggccagtgtg 2288101 ttgaggtctg tcaaaacctt caggtaaatg aaacactctc aatcgactgg gaacgcgaac 2288161 gccctcgcgt catttgggat gagggagttc cgatcaatga atcttcctgt gtcagctgcg 2288221 gtcagtgtgt aacagtatgt ccatgtaatg cactgatgga aaaatcaatg ctcgggcagg 2288281 ctggttttat gacaggcatt aaagaggacg tcatggaacc gatgattgat ctcgtgaaaa 2288341 atgttgaacc ggggtatggc agcatttttg ccatttctga agtcgaagcg gcaatgcgtg 2288401 aaacgagaac gaaaaaaacg aaaactgtat gtacgttctg cggtgtcgga tgttcatttg 2288461 aagtatggac aaaaggacgg gatattttaa agatccagcc tgtttctgat gctccggtta 2288521 acgcaatttc cacatgtgtc aaagggaaat tcggctggga ttttgtcaat tcaaaagagc 2288581 ggatcacaaa gcctttaatc cgtaaaaacg gagcctttgt ggaatcttct tgggaagaag 2288641 ccctcgatct tgtcgcaagc agattaggat caattaaaga gcagtacggt aaaggctctg 2288701 tagggtttat ttcttcttct aaaattacga atgaagaaaa ctacgtcatt caaaaactag 2288761 cgcgtcaggt atttgaaaca aacaacgtcg ataactgctc acgctactgc cagtctcctg 2288821 ctacagacgg attgttccgc actgtcggca tgggcggtga cgccggcacg attaaagata 2288881 ttgccaaagc aggcctggtc atcattgtcg gtgccaatcc ggcggaagga cacccagtgc 2288941 tcgcaacacg cgtcaaacgg gcacacaagc tccacggtca aaaactgatt gttgctgacc 2289001 tgcgtaaaaa tgagatggct gagcgatctg atctgttcat cagccctaaa caaggcacag 2289061 accaagtttg gctgatggct gttacgaaat atatgatcga ccaaggctgg cacgatcagg 2289121 cgtttattga tgagaacgtc aattactttg aagattataa agaaaccctt aaaacgtata 2289181 cgcttgatta tgcagaacgc atcacaggcc tttcaaaaga aaacatcatt caaattgctg 2289241 aaatgattcg tgatgctgac ggcacttgtg tcctttgggg aatgggtgtc acacaaaata 2289301 caggcggttc tgatacatca gcagccattt caaacctgct tctcgctacg ggcaactatc 2289361 gccgtccagg tgccggcgct tatcctctgc gcggacacaa taacgtgcaa ggcgcatgtg 2289421 atatgggaac attgcctggc tggctgccgg gatatcagca tattacagat gacaaagcac 2289481 gcgctaaatt tgaagaggca tatggtgtcg agattgatgg aaagcctggt ttagataata 2289541 ttcaaatgct tcatgccatt gaagaaggaa aaatgaaagc tatgtatctt gtcggtgagg 2289601 atatggcact ggtcgattca aacgcgaacc atgtgcatga tattttatca agccttgatt 2289661 tcttcgtggt acaggacatc ttcctgtcaa gaacagctca atatgctgat gtcgtcttgc 2289721 cggccactcc ttcacttgaa aaagacggaa catttaccaa cacagaacgc cgtgtccagc 2289781 gattgtatca ggcgcttccg acgcttggtg acgcaaaacc ggactggtgg attattcaag 2289841 aggtggcaaa ccgtttagga gcgaattgga attacagcca tccaagtgac attttctctg 2289901 aaatggcgag tctttctcct ctgtttgcca aagcaagcta tgaggtgctt gaaggctgga 2289961 acagcttcct atggggcagc ttcacaggtg aaagcacacc gcttctgtat gaagacggat 2290021 ttaatttccc tgacaaaaaa gcccgctttg ccctttctga ttggaccgag ccagcggcat 2290081 ttccggagga atatgacctt catatcaata acggccggat gctggagcat ttccacgaag 2290141 gaaacatgac aaataaatcg aaaggcatcc aagcgaaagt gccgaatgta ttcgttgaga 2290201 tctcacctga gcttgcacaa gagcgaggtg tttgtgacgg ttcgcttgta cggctcgttt 2290261 ctccgttcgg agcagtcaaa ttgaacgcgc tgatcacaga ccgggtacgg aaaaatgaac 2290321 tctatttgcc aatgaactcg acagacaagg agtcagcgat taacttcttg acgggccctg 2290381 cagctgataa acggacgaac acgcctgctt ataaacagac aaaggtccgc atggaagtgc 2290441 ttggcggctg tgaaacagcg ccgcttccaa aaacaaatcc gcgcaacaaa aaacggcatc 2290501 cgcaaaacgg agtcgaagca gaaagaaaat ggaaccgccc tggctatgta catctgactg 2290561 attaaacgat aggaggaaaa cgaatggcca ctccgattac gacgatcaaa aaagaaacaa 2290621 aaacagctga gcaaattaag cttgaaaaaa tagaagaact gaaagagctg ctggcggaaa 2290681 atgaggacgc cgtctctaaa acgatgacgt taatgaatga actcaatgat cttggaattt 2290741 ttgatgcggc aacaagcatg ctcagagcga aggaagacat tgccaagatt gcgcttggcc 2290801 aagtttcccg cgagcctgtc accaacctca tcaacacgat gatggccgcc ggaggcgcat 2290861 tgacaaaagc cgatcctgag tttacagcaa agcttttaga aagcgtaatg gctgggactg 2290921 aacaggcaca aagcttttta aaagaagaca agaaagtcgg gattctcgac ctgttaaaag 2290981 caatgaacga tcctgacatc aacagagccg tcgggttcgg ccttcagttt ttaaaaggca 2291041 tgggaaaaga acttcgagaa caataacaga aaaacagcca tctctgatga tggctgtttt 2291101 tttattcgtc ggcttcttcc agacgcttct tgtaaataag tgaacggtca gcgcaaaaga 2291161 aggcaccggc taaaaatacg caatccgcta aaaacatcgt cgatttctgg cctaatgtta 2291221 agccttgatc agggagaact gcgcctatat ataaaaaagt gctgactgca agcaatgtaa 2291281 aagcaaaatg cttgtagtct tcttttaaag atttcattct atttttgttc aaaagaatca 2291341 cctgccagat tcatagtata cgactattat aatataatcc ggcggcttac agagaaagta 2291401 attctatcca tttgttatat attttcaagc gcttggccga tatcttccaa caagtcttcc 2291461 gcatcttcaa ttcctacaga aattctgatc aagccgtccg taatgccgag ctcaagccgg 2291521 cgttctctcg gaatagaggc atgtgtcatt cttgcaggaa cagaaattaa gctttcaacc 2291581 gcccccaggc tttcagcaat ggtaaacagt ttcagatttc ctaaaaacgc atcaacccgt 2291641 tcttcactgc caatatcaaa ggagatcatg ccgccgaagc ccgctccttg cgtttttgca 2291701 agctcatgtc cgggatgatt tgaagaacca gggtaatata acgtttggac agcagggtga 2291761 ttctcaagaa agcttgcgat tttccgcgca ttttgatcga tcgcttccat tctgagtccc 2291821 aacgttttga ttcctctcat taacagccag gaatcttgag ggccgagcac gccgcctgtg 2291881 gagttttgca caaaatgcag ctcttctcca agctctttcg aagctgtcac aactaaacct 2291941 ccgacgacat cactgtgtcc gccaagatat tttgtcgcac tgtgcagtac gatatcagcg 2292001 cctaaagtaa gcggctgttg aaaataagga gtattaaagg tattgtctac gataagcaga 2292061 acacccgctt tttttgcgat atcagccatg agcgtcaggt cggtgatttt gagcaacggg 2292121 tttgtcggtg tttcaatata aattgctttt gtattagggc gaatcgcttt ttcaacttct 2292181 tccctgctgc tcgtatcaac aaatgttgat tcaatgccaa gacggttaag cacctttgtc 2292241 atcacgcgat atgttccgcc gtacacatca tcagtcaaca cgacatgatc tccgctgtta 2292301 aacagcatca taaccgctgt aatggcagcc attcctgagc tgaacgcata gcctgcttcc 2292361 ccgctttcca gttctgtcac aagtgcttcg agagcggttc gagtcggatt ggccgttctt 2292421 gaatactcgt agcctgtatg ctgccctgct ttcggctgct tgtacgtgct tacttgataa 2292481 atcggcacgg aaactgcgcc tgttttctca tcacctgtga ttccgccatg tatcatcaat 2292541 gtttttttct tcatatcaga tgcctccttc gtatatttgt ttgctgatat atcgatcgct 2292601 gctgtcagga aatactgtga caatgttagt tccagcggat gcttttttcg cttcctccaa 2292661 tgccgcataa agcgctgcac ctgaagagct tccgatcagc aggccttctt tttctgccgc 2292721 ttctttcaca agtctaaacg cattctcatc tgttacggtg tagatctcgt caaaatggct 2292781 cttatccata taatcgggga taaactccat gccgatgccc tctgttttat gagcgtgggg 2292841 ctctcctccg tttaaaatcg agcccaccgg ttcaacaatc accgttttga ctgctggatt 2292901 tttttctttt aagaaggaag ctgtccctgc gaatgtgcct cctgatcctg cccctgcgac 2292961 aaatgtatga atattcccgt caagcgcttc ccacatttca ggtccaagcg tcttatagta 2293021 agtcgatgga tttactcggt ttttaaattg caaaacgcaa taagaatttt caatttcagt 2293081 ctccagctga atggcttttt gaatggctcc ctgcattccg tcttgacgcg gtgtatgaat 2293141 gattgatgcg ccaagcgctt gcataatttg ctgtttctct ctgctgaaat gttcagggac 2293201 acagaaaatc gctttcagcc catattttct ggcacttaac gcaaggccga tccctgtatt 2293261 gcctgccgta gcttctataa tcactccgcc gggtttcact ttgcctgaat cgagcgcgtc 2293321 acgaatcagc atatctccca gtctgtcttt gatgcttccc cctggattca tcatttcaag 2293381 cttggcatac accgcgactc cttctggaac atcaaagttc ttcaagcgga gaagcggtgt 2293441 attcccaatc agctcggtaa tgtccgtaat cactgtcata tatgtcctcc tccttaatag 2293501 aggttgtttt tagagaaaaa cggaggagaa cgttctcccc gttttaatga attcgtttga 2293561 tcacctttaa cacaagctct gttgaatgaa cagccgcctg ctctaaaaat tggtcaaatg 2293621 aaacatgtga ttctttgcct gcgatatctg ataacgctct gatgacgaca aacggcgttt 2293681 taaattgatg gcatacttga gccactgccg cagcctccat ttcaaccgcg tacagatcag 2293741 aaaatctcgc acgcacctct tcaacccgct tcggatcgtt catgaaagaa tcgcctgttg 2293801 caatcgttcc ttttgcaacc tgaatgccgt cgagttcaga taccgcttct tcagtgatgc 2293861 tgatcagctt ttcatccgcc gcataagcag ccggaagacc cggcacttgg ccgtattcat 2293921 agtcaaaagc cgttacgtct acatcatggt ggcgaacgtc agtggaaatg acgacatccc 2293981 ctacattcaa tgtatgatga aatccgccgg ctgagcctgt gttaatgaca taatcaggct 2294041 tgtaacggtc aagcagaagc gtcgtgctga tagcagcatt tacttttcca attcctgatt 2294101 ttaaaagaat cacttcagtt ccttcatatt cgcctgttgt aaattcacag tgtgcgatcg 2294161 tttctgtttt tgcattttca agtttgtttc ttaagatggt aacttcctct tccattgctc 2294221 cgatgactgc tagtctcatc tattcacatt cccttcactt taccgtttga tcgcctccat 2294281 tatccacacg aagtcgtttt gctgagtgaa tcggactgca aaaccttcag ctgtaaacat 2294341 ttctttcaac gcatccaatg taggataatg ctctgtctct aaatcatttg caagctgata 2294401 aaagccttga gaacgggctt tatcgatagc ctgttgatac gcttgcgcat tttcaaagac 2294461 ggtatcggca aacactattt tatcatgcaa gtgaaggtat ttgccatatt gctttatggc 2294521 agcccgcttt tcttcgtcag tcaaatgatg aaaagcatat gaactgacaa tcgtatcagc 2294581 ctgaaatggc ggctcaggga atgtcaggaa gtctccatca acgatttccg tcctgcctga 2294641 gagcttgtca gaagccagtt tacgcattgc tggagaaggt tcgattccaa atacagtttt 2294701 gcctgcatcg agcagcttag ctgtcaaatt cccggtcccc gggccaaatt ctaacacatg 2294761 cgttccagat tttctgacga tggcatcaag gatatgatcg tagcctctga acgcttcttt 2294821 atactgaata tctaaacctt gtactgtttg atcataagtt gctgcccaat cttcaaagag 2294881 agggataaat tcacggccca tatttgtcac actccatatt taataattcc tataagtata 2294941 ctatggatta atgatggaac agttcctata ataccacata ttctgaaaag caggtactaa 2295001 aacactttgt gtattttatg ccatctcata ttgcgcattg accgcaaaaa agcttatact 2295061 tcatatgact tgtgaaagct ggagggtcaa gacatgaatt ttcaattaga tctgattaaa 2295121 gacaaagtgg aattttttga agcggcttca ttgcaggagc ttgaaaagaa aatcaataca 2295181 caaattgaaa acaataaagc catcatgctc cgggtgaaat ctgtttcaca ccaaactctt 2295241 gtggcagaag gaagaatatt gtacagcgcg gtggttcatt tctcagctga agcctaaaac 2295301 aaaagcagcc ggttttaacc cggctgcttt tgtttatttt agcttttcta cttttgtcgg 2295361 cttccagcct ttttcatcga cccatgtaat cgtgacttga tatttattcc cagtcgcctt 2295421 gtccaaaatc ttgcctttgg catcctgagg gctgccgtta tttccaagcc agagcaccgt 2295481 catgttatct gttgagacac cagttgcgta cgaaatggct ttcagcatct cagcccagtc 2295541 ttgtgagctt gaatcataag tagcggcatg ctcgccagtc tgctcagttc cgactgcttt 2295601 ccagtcagga ttttcatacg ttttttccac atcgctcgat gagccgcctt ctgttacttt 2295661 tgcatcttta agcccgtcac cggctgaatc tgagcttgaa tctgaatcag agtcatcttt 2295721 tttagaagaa gaatcatctt ttttggaatc agagtcagaa gacttctcag aatccttttc 2295781 gctgtcagat gtatctttct tgctgtcttt tatatcctca tccgatttct tttccgtctt 2295841 tcctgaagcc ggagattcct gtttttgcgc cgtttcagaa tccttgctga catctttgct 2295901 agaaggactg ttaatgaaga gattcgctgc tactacgaca attagtatgg atacgattgc 2295961 gattaaaatg ttaagcacta aattggcttt tctgcgttta tcacgatttt cataacgaga 2296021 ttgattattg ctcaataatt ctgcactcct ttatccctct tggctcagca tatattttaa 2296081 catgtgctga gaagttgttc tatttctgat tgatttcaat ttcgtgtact tttttaacaa 2296141 tatcataaaa caccgaattt gtcagagcct tatctcccgg tgtatccatg tgtaaaacaa 2296201 ctagagcgta tttcggctta tccgcgggaa aatatccggc aaaccatttt tcgtagagcg 2296261 tttccttctc ttttgaaagc ttgcctgtct gggctgtgcc cgacttccct gctacagtat 2296321 acggaagatc ttgaaacctt ctgcccgttc cggaaggaga ttctactacc cgccgcagta 2296381 ttttttgaag ctgctgtgac gtatatttgt ctatcgtttc ccctttgagc ttctgatctt 2296441 taaacgtaac gagcgttgtg ccgttcttat actcaatttg ttcggcaatt ttcacctgcc 2296501 gtttttctcc gccgcgggcg attgtcgcca tcatattggc tacctccagc ggcgttacct 2296561 ttacattttt ctgcccgatt gctgtttgcg caatggcttt tttgactgat ttgtcttttt 2296621 catcccccca aatcacgccg cttttttcgt tatacagctg gcggaaatcg gtttcgtggt 2296681 acagttttcc ctcccagcct gcccgatcag tgagagccag cttctcggac atatcttcaa 2296741 taaccgagct gtcttttttc attaattgtt ctgcaagact cgtaaatgtg taattacagc 2296801 tttgggcaaa actttcatca aaagacaagg tgcctttgtc gtcccccggt tccccgtaca 2296861 ggtttaaatt gcaattaaag gtttgactag gcttcaccat attattttcg attgcagctg 2296921 cggcaatgac tgttttaaaa actgatccgg gatagattgg cgtcagcata taattttgaa 2296981 gtgtgttttg ccgggacacg tctgcatctg gtttgcttac aattcccaga acactgctat 2297041 tttcgatgtc cagcagcaca gctcctccct ttttcagccc ctgttcatcc aatacctcct 2297101 ccatcgcttt ttgaatgctt tgatcgatcg ttgttttgat ctggagcgga taaaatgtat 2297161 tggcttcagc tgtatatttg acgtccatgc caaacaaagg gtttcctttt ccgtccacat 2297221 gatataaaag ctttgtgtct tgttccggaa gcaaaaactc gtcaaatgtc cgttctaaac 2297281 cggttgttcc gatttctgtt gtaatcggaa ggctctcctt gtcaggatat ttcttgcgaa 2297341 gcagcgccgg atcttggttc gtgctcccta tcgtatgtga agcaaggctg ggcttgtctt 2297401 cattctccat atatacgccg taaatgccgg gatatttcaa agaattgatt tttgtgatag 2297461 attgttttga aagtgttttg attttctttt gctgcaaaat gaccggtttt tttgcctgac 2297521 ctagtgtctg gcgcaaatca tcttcagaca tgccgaggat gtccgcaact tttttgatcg 2297581 gccaatcctg cgtcagcaga aaagggaaca aaacaaccgc aggctcgctt tgtcctgtca 2297641 gcgcccgccc gtttcgatct aaaaaagagc ctcttccatc tgaaatgagc acttcctccg 2297701 tccgctgttt cacactttct tgaatcaaat taattttctt tttagaaaat gattctgtga 2297761 aaaacagctg gatttctgca agtctcagca gaagcagaaa aaatacaatc aaaaaagcga 2297821 tgactgccag cttcattcgt ttcgatatct tcataaaaaa acacctcacc cacattgtgg 2297881 acgaggtgtt tcgctgctaa acagatatta tgaaattttc acaattttca cgagcatttc 2297941 tccgcccggt gtttgtactg tgacttcttc atctactttt ttgcccaaga ggctttttgc 2298001 gatcggtgaa tcgtttgaga ttttcccttc aaacgggtca gcttccgcgc ttccgacgat 2298061 cgtatatgat tcttcatcac cgtcaggcag ttcgacgaaa gtgacggttt tacccaaacc 2298121 gacaacgtta gagccgccgt catcttcaat gattttcgca ttgcgaatca tattttcaag 2298181 agtcgtcacg cggccctcta caaatgcctg ctcttctttc gctgaatcgt attcagagtt 2298241 ctcggaaagg tctccgaagc ttctcgcaat tttgattcgc tctactactt cttttcgttt 2298301 aaccgttttc aaatattcta attcttgttc aagtttttgt tttccttctg cagtcatagg 2298361 aaaaactttc tcttgtgcca tgtcccttca ctccttctgg ttgtccctca acatcttcga 2298421 ttatgtatga gagcataaac taaaaaatac aagaatgaga acacagggca gtcctcgttc 2298481 ttctctccca tataggtact gtttatctta aactgaatcg tgtcgttctg caaatatttc 2298541 gcgtttataa acagggaaag aagggaattc gcacattccc ttcctgccta tacataatat 2298601 ggtcagagtt atttatgtct atgctatggt attacaaaat cgcgttttgt tcaagaatgg 2298661 tttgaatttt tgtgaccatc agatcaattg cgacgtgatt ctgaccgcct tccgggataa 2298721 taatatcagc gtatcgtttc gtcggctcga cgaattggtt atgcatcgga cggaccactg 2298781 acacatattg ttcaatgaca gaatcaatag agcgtccgcg ctcattaata tctctcataa 2298841 tccgtctgat gatacgcaag tcagcgtccg tatcaacata aagcttgata tccatcagat 2298901 cacgaagcct tttgtcttca agaacaagaa tgccttcaag gataataaca tcctttggct 2298961 ctacgtgaac cgtttcttct gaacgtgtgt gaagcttata gtcataaatc ggcttttcaa 2299021 tcgggcggta attcaataga tcttgaatat gctcgattaa atagtcatta tcaaacgcaa 2299081 gcggatgatc atagtttgtg ttcagccttt cttcaaacgg aagatggctt tggtctttat 2299141 aataaaggtc ctgctggatc attaaaattg agtgtccttt aaactgttca taaatggacc 2299201 gtgtgacact cgtttttcct gaaccggaac ctcctgcgat tccaatgact actggattct 2299261 tacccatggg ctgttacttc ccctttctca tcatgttgct cggataaatc tttttgtcta 2299321 gtttgaattt gacaatttgc aggggatggc gggcagcatc tagctcattt ccgtcttcgt 2299381 cccaaatggt ttcaatcgta tgtgtaaagt tttcgatttc tggaccgaaa aattccactt 2299441 cgtcgccttt tttgaagaaa ttgcgctgct gaagcgtgac catttgtgta tcttcatcat 2299501 aattcagcac taagccgaca aaatcatatg tcgttttctt ggcgtgttcg ccgaacattt 2299561 gctcttcata gcctggcgtt ccttcaaaga aagctgtcgc agtgtccctg ttggcgcact 2299621 tatcaagctc ttcaagccat tctttttgaa tcacaaagtt ttctggatca gcgcaataag 2299681 catcgattac tttgcggtat acgctgacaa cagttgctac atagtgaatg gatttcatgc 2299741 ggccttcaat ctttaagctg tcgatcccca tttcaatcat ttttggaatg gattcaatca 2299801 gcttcaaatc tttcgggctc atcgcaaatg gtgcatcttc ttcaccatac aaagcaacgg 2299861 cgttggcacc gtctgtttgg tagagatcat aatcccagcg gcatgactgg cagcagcctc 2299921 cgcggttgga atcccgcgct gtcatgtgat tgctcagcac gcagcggccg gaatatgcaa 2299981 tacacattgc gccatgaatg aaggattcga tttcgatatc taccttttct ttcatttctc 2300041 tgatttcaag agcgctagtt tcacgtgcca gcacgacgcg gtcgagacct tcttccttcc 2300101 agaactggac agccttccag tttgaaagag actgctgtgt gctcaagtga acctcaacat 2300161 tcggcgccac tctgcggcat gtttcaataa taagcggatc tgccacaata ataccggcaa 2300221 cgttggcgtc tccaagcgct tttaaatagt cttcaagccc gtccatgttt tcattatgag 2300281 cgaaaatatt cgttgttacg tagatcttcg cgccatattt ctttgcgaat tcaacgcctt 2300341 ctgcaatttc ttcgatcgta aagttatcgg cattcgagcg aagcccgtat tcctgtcccc 2300401 cgataaagac cgcgtccgct ccgtaatgaa cagcgatttt cagcttttca agattacccg 2300461 caggtgcgag aagctccggc tttttcgtaa tcacacgctt tccattaacg attgtggata 2300521 ttttatcatt tacggcagtc atagcttaac ctccttttga ttaataaacc gtttccttga 2300581 agaagaatcc ggtatcaatt tttctgttta ctggctggat gctttcaatg cgttcgatcc 2300641 agtcttcttt tttcgcttcg tattcgtcac ggttttccac gcacaaatca attgcttctc 2300701 tgtacatttt ggtgacttct attaggtatt caggcatttt caaaacacca tcgattttga 2300761 aagaatcaat tccggcatct atcaattcct cgagctcatc aatgatgcac acatcgttcg 2300821 ggctcatgat gtgagtgccg ttttcatctt cgaaaatcgg atatttatta tcgcgttctt 2300881 tatcgtgtaa aaacatgcct gattcttttt tctttctttc aatgtccatg actttgccct 2300941 gatattcaaa atagtttcca atcaaagaac gcttcgattg gaacatgcac gtcattccat 2301001 gcacctggat ttcaatttcg acttcagcat tttctttaat ctcaacaatg ctgtccatgt 2301061 ttaattctct ggcaagcaca gaacgcgccg cacccttgcg tccccagtag ttgcatgtat 2301121 aatagttggt gcctgtcgtt tctgtgctcc aatgaagctt cagatcaggc gcagattcac 2301181 gggcagccat cagcacggca ggatcgccga ataccgctgc atcgacaccg gcttctgcta 2301241 agaaagccag atattcgcca agctcaccca ctttatcatt atggaaaatt gcatttacag 2301301 caacgtatac ttttgcccct tctttgtgag caatctctac ggcttttgtt acatcttcac 2301361 gagaaaattc tccggctaat ctcaagccgt atctctgttc cccaactaaa aacgcagttg 2301421 ccccagcctg tatgagcggc aaaatgtccg ctgtactcgt cggcgtcact aagagctctg 2301481 gttttttcat gacgttcacc tcttcttttt actaatcgca agtccgtccc cgacaggaat 2301541 aatcgcagtt tgataatccg gatgattcat cagccaatga ttatattcat caattttggc 2301601 tacaagcctg cgccttctct tcggttctat tttgctgtaa tcctctgcca ccagaccttt 2301661 aaacagcacg ttgtctgtta taatcacccc gtccggtgaa agcatcggtt catataaatg 2301721 aaaaaagttt tgatactgac cttttgcagc gtcaataaaa atgacatcgt aaggcgcggt 2301781 tacatgaacg gcgtcggcta attcaagcgc atctccgtaa aaaacatgaa tccggtcatc 2301841 aagctgaaat tccttgatat tgtttaccgc ttcttcatgc cgtttctcat tgcgttcaat 2301901 tgtatatatt tcagcagacg gcagttccag agccattcga atggctgaat aaccaatggc 2301961 cgttccgatt tctagtattt ttttcggctg tttcacagac aaaatttgaa gcagcacctc 2302021 catgcccgct ttttccataa tcgggacatg atgttcttct gcatatgctt caagtctctt 2302081 cacgttatcc ggccgaggct ttaataatgc ttctatatag tcatttattt gttcataccg 2302141 gtcagtcact acaaacagcc tcccgttcta aaaaggagtg ccccagtctt atgcgcagga 2302201 cactctctga atacatcatg atacatcggt aaacaacccg atatatttta tcataaaacc 2302261 ttgcggaaag cgaacaaaag gagagctttt tgctctcctt ttatttctca ttttttgagg 2302321 aaatgtattt ttcttttgct ttattatgct cttttagcgt ttttgtaaat acgacctcac 2302381 catttgattt ggccaagaaa tacagatagt ccgttttatc cggatgcagc gctgcttccc 2302441 atgatgacat gccggcattg gcaatcggcc ctggcgtcag ccctgtgttt ttatacgtat 2302501 tgtatggtga atcgatttcc agatccttat aaagaacccg atctttatgc ttgcctgccg 2302561 cgtacaggac ggtcggatct gtttggagcg gcattttctt tttcaggcgg ttataaaaga 2302621 cgctcgcaat tttatggcgg tcggcttttt cagtcgcttc ttcttctatc aaagaagcca 2302681 ttgtcagcag cttatgcaca gaaactttgt ttttcttcat ttctgattta tatgtttcca 2302741 cataagaatt tgtctgctta atcattgcct tgataatgtc ttcaagtgat gtgtccggat 2302801 cgttaaaagg gtatgtagcc gggaataggt acccttcaag cgggtgctta atgtttttat 2302861 tgaaaacatc atttgtcaca gtgtccggga attctttctt cagctgattg ataaatgttt 2302921 catcgtccag cttcgctatg acttgttttt tagagtattt tgtttcatca gcaatagcag 2302981 ccgcgatttg ggtcagctgt gctccctcag tcactgtgat ttgaaaagcg taacctgtag 2303041 ccccgcttgt cagcttctga ataatggcat ctaaatccat acctttattc agatggtaga 2303101 atccggcctg aaacccggaa gcacctttat atttcacata gtactgaaac gccttctcgc 2303161 tttttatgac atcatttttc tttaatatcg atgcgatggc tgaaacagac gaaccgctcg 2303221 gaatgttaat attaactgtc gttttactgt ctttttcaac aggttcaagc aatgatttcc 2303281 catataaaaa tgccccgcca atgatgagaa acagcacaac aatggaagac agtatgattc 2303341 tttttttatt aaaaaacgat tttttttgct gattgatata cattaggtct cctcccatca 2303401 gctcttatac tacatgattc attgtatttc ggcaatttat tacaaaaaga ggcctgcata 2303461 aagcagaaaa aagccggagc agtatagctc cggctttggt ttggcgcgat gttttactct 2303521 tcgtcttcgt ccgctaagaa tgtgtttagt gtttcttcga tcatatccca ttcttcgtca 2303581 gtttcaatcg ggaatagctc accgttttca ccgtcttcgt ttggcgtgaa gctggaagca 2303641 agaatttcta cttcttcgtc atcttttgat tcgattggat agtacaagac ataagatttg 2303701 ccaaactctt cattttcaaa tgtaaacagc acttcacaaa gctgttcatt tccttgatcg 2303761 tcaacaattg taatattttt ttcgccgtgt tccattttct tcacctctgg ctttaattta 2303821 agctgtcaag atatccttgt aaaatcataa cagccgccat tttatcaatg actttttttc 2303881 gtttttgcct gctgacgtca gctgcaatca gcattttttc agccgccatt gtggtaagac 2303941 gctcgtccca cagcacaaca ggaacattgt acgttgtttc aagcactttc gcaaatgttt 2304001 ggctggcttc gcctctcggg ccgactgttc cgttcatgtt cttaggaaag ccgagcacga 2304061 ttttatctat agtatagtcc tttatcagtt cagataaacg ggataaacca taatcgcctt 2304121 ctgcttcatt tatctttatg gtctcaatgc cttgagcagt ccagcccatt tcatcgctca 2304181 gagctacacc gagtgttttg gttcctaaat cgagtcctaa tattctcatt ctttatttac 2304241 gcctctttat gctgttctaa ataagacttt accaattcct cgattaattc gtctctttca 2304301 agtttgcgaa ttaaattgcg agcgtcacga tgcctaggaa tataagcggg atcacctgac 2304361 agcaagtatc cgacaatctg gttgattgga ttgtagccct tttcctgaag cgcgtcatac 2304421 actgtaatca gcacctcatt tacgttagtc tcagcagaat catcggagaa attaaatttc 2304481 atcgttttat caaacgagct caccgttttg cacctctttc ccaaattcgc aggcaaagtt 2304541 cagcctgggg tcctaatctt accatcattc tacactacat gggcgaatta taaaacggat 2304601 ttcacccaat cttctacaga agccaaagct tcttctaatt tttccggctg tttaccgcct 2304661 gcctgcgcca tgtccggacg gcctccgccg cctccgccgc aaacttccgc agcttgttta 2304721 accagcttgc cggcgtgaag tcctttctca atgaggtcct ttgtgactcc ggcagagata 2304781 ttaactttat cgttttgtac cgcaccaagc acgatcaccg cagagccaag ctttgctttg 2304841 agttcatcga ccatagtgcg gagatgattc atgtcttttg catttacttt tgccgcaagc 2304901 acgtttacgc cgtcaacttc ttttactttc gacaggattg ctcctgcttc cacgttgcct 2304961 agttttgcaa gaagagattc attttctctt tgtgcatcct tcagttcagc ctgcagagcc 2305021 gcgacccgtt tcggcacttc tttgatattt gttttcagct cgtcagcggt ctgcttcaat 2305081 acagaaatct ggctgttcat ttcgacgtaa gcgccttgtc ccgttacagc ttcaatccgt 2305141 cttgtgcctg ctccgattcc ggattcagaa acgattttaa acaagccgat ttctgctgta 2305201 tttctgacgt ggcagccgcc gcacagctct aagctgtaat ctccaacttg aacgacacgg 2305261 acaatatcgc catatttttc gccgaacagt gccatcgcac ccatttcttt tgcttcagcg 2305321 atcggtttca aatcaatgct gaccgggatg ctcgcccaga tcttttcgtt tacgattctt 2305381 tcaatttgtt cgagctcttc ttttgtcact tggccaaagt gcgagaagtc aaaacgaagg 2305441 cggttttccg ttacaagaga gcccgcctga ttgacatgag ttccaagaac atcttttaga 2305501 gcctgatgca ataaatgcgt tgccgtgtgg tttttaatga cgccgcttct catatggtct 2305561 tcaacttcag ccgtaacatg caggcctttt tgaacagtac cgctctccac aacaccttca 2305621 tgcacatgct ggccgttcgg cgctttttga acatctttaa ttcttacaac tgcctgctcg 2305681 cttcggagat agcctttgtc gccgatttgg ccgccgcttt ctgcatagaa cggtgtttca 2305741 tcaagaatga tttgaacgct ttctccttca tgagcctctt cgattaattg gccgtcctga 2305801 agaagcacaa tgatattggc atcagctttg gtttgagagt agccgacaaa tgtgctttca 2305861 actgtcacgt cgcgcagtgc gccgccctgc acctgcatgc tgccgacatc ctggcgggcg 2305921 tttcttgccc gttcacgctg ctggttcatt tcctcctcaa agccctcatg gtcaaccgtc 2305981 atgttctcgt cttctgcgta ttcttcagtc aattcaaccg ggaatccata cgtatcatac 2306041 agtttaaaca catcagcacc tgagataacg ctgctgccct tgtctttttc ttttttgatc 2306101 atttctgaca ggatcgcaag cccttcatta agggtctcat ggaagcgttc ttcctcggtt 2306161 ttaatgactt ttgcgatgaa atccgctttc tctttcactt caggatagaa atcagccatg 2306221 atttctgcga caaccggcac taaatcaaac atgaacggac gatggatgtt gatcgttttg 2306281 gcataacgca cggcacggcg taataagcgt cttaatacat agccgcggcc ttcatttgac 2306341 ggcagcgcac cgtcactgac agcaaaggca accgttctga tatggtcagc aatcacttta 2306401 aacgcagtgt ctttcacatt gtctttgcca tatgtttcac cagaaatcga ttctgttgct 2306461 ttaatgatcg gaacaaacaa atcggtgtca aagtttgtcg gaacattctg gatgacagac 2306521 accattcttt caagacccat gcctgtatca atatttttct ttggaagcgg tgtgtacgtg 2306581 ccgtcagggt tatggttgaa ctctgagaac acaaggttcc atacttccag gtaacggtcg 2306641 ttttccccgc ctgggtaaag ctccggatct tctggatcat taccgtatgc ttcaccgcgg 2306701 tcgtaaaaga tttccgtatt cggtccgctc ggcccttcac cgatatccca gaagttccct 2306761 tccagacgga taattctttc ttcaggaata ccgatttttt tcgcccaaaa ctcatatgcc 2306821 tcttcatctt caggatgaac cgtaacagag agaagctctt tgtcgaagcc aatccacttg 2306881 tcgctcgtta aaaactccca agcccatgta atggcttctt ctttgaaata atcgccgatg 2306941 gaaaagtttc cgagcatttc aaagaaagtg tgatggcgcg cagttttacc tacattttct 2307001 atatcgtttg ttctgatcgc tttttgagcg tttacgattc ttggattttc cggcacgaca 2307061 cggccgtcaa aatatttttt cagcgtcgca acaccgctgt tgatccaaag cagtgaagga 2307121 tcctcatgag gcactaatga cgcgcttggc tctaccgcat gtcctttttc tttaaagaaa 2307181 tccaaaaaca tttgacgcac ttccgcagaa gttaagtgtt tcattgtatt tcctcctcta 2307241 taaaaatcga aattctcttc agtgacagca aaaaagccct ccccctatgc aaaccaacgt 2307301 ttacacaggg acgagagctg tctcgcggta ccaccctgat tacgggcatt catgcgcccg 2307361 tcacctttaa ccctgtaacg caggataagc ggcagtgatt aactgcactc aggattagct 2307421 tcctccgatc ttctgataaa gctcctttca gcttatggag cttctctctt taacagggct 2307481 tcggcgtact cagatccgtc actcgagatt cgtatgtatt ctacgagaaa ttatagacaa 2307541 gcggcacgcc gatgtcaatg ctccgtcctc atccgcaaaa aatggatcat cattactttt 2307601 aaaacagccg tcgcaggaac agccagaatc atcccgacga tacccgcaag ctcccctccg 2307661 gcaaggagtg caagcatgat aacgaccgga tgcattttaa ggcttctgcc gacaatgaac 2307721 ggactgagga tatttccttc cataaactgc agaataaaca ccgtaatcac cacaacaaga 2307781 accgccttga ctgagatcgt catcgcaatt aacaacgcag gaacagctcc gatgaaaggg 2307841 ccaaaatacg ggatgacatt cgttacccca gagataaggc caagtatcag cggatacgga 2307901 agcccaaata cccagaacga aatgcctgca atcacgccaa gaatcaagca gaccaaaagc 2307961 tggccgcgga tataatcgcc aagcgaatca tccacatccc gcaaaaaggc gctgccccgc 2308021 tttctccacg acttcggagt caagtaccat actgtctttt tcattaactc aatgtccttc 2308081 accatataaa acacgagaaa agggattgtt gcagcaatta agaagtaatc aagcacattg 2308141 cggatcccgc tgatcgcacc ctcgatcgtt cccgcaaaaa acgcctccgt ctggcggatc 2308201 attttatcta tacggtgatg cataccatca ggccagtcat ccgtatggtt atgcacatga 2308261 agaagaagcc cgttatacgt ttcggcaaac atgggtatat tttctgacaa atccgtcagc 2308321 tgcacgatta aaacaggcac ccctttatac aacgcccagc caatcccgcc aaaaaaaaga 2308381 acataaatga ccaagatgct caaagtccta ggcaatcctt tgccatgcag ccattctgtg 2308441 accggaagca ataaataaga tataaaaata gaaatgatca agggaataaa gatcgttttt 2308501 atgacgagcc aaaagggtga ccataacata tcaagcataa aaaagacata gactgttaac 2308561 agaaccagca aacaaatagc cacccacaac aaaagctgca ccggtttttg gagcatctgc 2308621 tttcacctca cctatatctt ttgaggttta caaggaatta ttctttatgt ttctttagtc 2308681 agtcagaagt catggacatt ttttcacttt taattttcag aaaagtttga tcatttactt 2308741 tttggtcaaa ttttctgata ggaggattgc gatgatcaca tttcaaaatg taaacaagca 2308801 ttacggagat tttcacgtgt taaaacaaat taatcttcaa atcgaaaaag gtgaagtcgt 2308861 tgttatcatc ggcccatccg gttccggtaa aagcacattg ctcagatgca tcaacagact 2308921 tgagtcgatc aatgagggag tgcttacagt aaacggcacc gccattaacg acagaaaaac 2308981 tgatatcaat caagtgcggc aaaatatcgg gatggtgttt cagcactttc atttatatcc 2309041 gcataaaaca gtgctgcaga acatcatgct ggctccggta aaagtgctta gacaatcacc 2309101 tgaacaagca aaggaaacgg cgcggtacta tcttgaaaaa gtcggcatcc cagacaaggc 2309161 tgacgcctat ccttcccagc tttccggcgg gcagcagcag cgtgttgcca tcgcaagagg 2309221 actggcgatg aagccggagg tcatgctgtt tgacgagccg acatcagcac ttgatcctga 2309281 aatgatcggt gaggtgctag atgtcatgaa aacactcgcc aaagaaggca tgacaatggt 2309341 tgtcgtgaca cacgaaatgg ggtttgccaa agaagttgcc gaccggattg tcttcattga 2309401 cgaaggaaaa attttagaag aagcagtgcc ggctgaattt tacgcgaacc cgaaggaaga 2309461 acgggcccgc ttattcttaa gccgtatttt aaatcattaa aacagaaatg ggggagcttg 2309521 tatgaaaaag attttttctt tagcattgat ttctttattc gctgtcatct tgcttgccgc 2309581 ttgcggcagc aagggatcaa acggagaagc ctcaaaggag agcaaaaaag atacgctagc 2309641 cgccattaaa gacaatgaca aaattgtctt cggcgtaaaa acggacactc gactgttcgg 2309701 tcttaaaaat ccaagctcag gtgagattga gggttttgat attgatattg ctaaacaaat 2309761 cgctaaagac attttaggtg atgagaaaaa agctcaattt aaagaggtca cctcaaaaac 2309821 aaggattcct atgctgcaaa acggggatat cgacgccatt gtcgccacaa tgacgatcac 2309881 tgaagaacga aaaaaggaag ttgacttttc tgatgtctat ttcgaggccg ggcaatcgct 2309941 tctcgtgaaa aaaggcagca aaatcaagag tgtcgagaat cttggcaaag gctcaaaagt 2310001 tcttgcagta aaaggctcca cctcctctca aaacattcgt gaaaaggcgc ctgaagcatc 2310061 tgttttagaa tttgaaaact acgcagaagc ctttacagcc cttaaatcgg ggcaaggcga 2310121 tgccctcacc acagataatg caattttata tggaatggct gatgaaaata aaaattatca 2310181 attaacagga aagcctttta cagatgagcc ttacgggatc gccgtgaaaa aagggcaatc 2310241 tgctctcgcg aaagaaatca acgcttcact taaaaagatg aagtcggatg gcagatacga 2310301 tgaaatttat aaaaaatgga tcaaagaaga cccagctgaa taacaaccat cccgggatga 2310361 gcaggcgatg ctcatcccaa tttgataagg agtgaatagg cagatgaatg tgtcaattct 2310421 tttcgataac ttcagcatgt atatggacgg tttttaccat accttgctcg caagtgttat 2310481 cgcgctggcc ggcagttttg tcctcggcgt tgctgtagcg gttatgagaa taacagtctt 2310541 taagccgctg caatggctcg ggaccgcata tgtagaattc atccgcaaca tccctcttct 2310601 tttaattacc tttgttttct atttcggact tccaaacgca ggcctgaggc ttgacggttt 2310661 tcaagcggga acggttgctc tcaccattta tacctctgcg tttatcgctg aagccatcag 2310721 agcaggcatc cagtctgttt caaaagggca gatggaagcg gcacgctcgt caggctttac 2310781 ctacagccaa gccatgctcc atatcatttt gccgcaggca atcaaaatcg tcattccgcc 2310841 tttaggcaat caatttttaa acttagtcaa aaactcttcg attcttgggg ttgtggccgg 2310901 attggatctt atgtaccaag ccgatttagt ttcgtcgagc acactcgttg tatttgatgt 2310961 ttatattttt gtggcgcttt tttacttagt gctgacgatt ccgcttagca tcggtgttaa 2311021 ctatctggaa aaacggctgg aaaaaagcta ttgataagga gtgagttaca ttggatttca 2311081 tcggtgctta ttcacaggag catttagcgt ttttatggga tggctttctc gtcaccttgt 2311141 acgttgcttt catctccatc attctgagct ttttcttcgg tttaatcgca ggcaccctgc 2311201 gttatgcgaa agttcccgtt ctttctcaat tgattgcagt tctcgttgaa acgatcagaa 2311261 acctcccctt gctgttaatt attttcttta cgttttttgc ccttccggaa attgggatta 2311321 agcttgaaat tacagctgct gcaattacag cactaacgat ttttgaatcc gctatgctat 2311381 ctgaaattat ccgaagcgga ctgaaatcaa ttgacaaagg acaaattgaa gcggcgcgct 2311441 cctccgggct gagctataca cagaccctgt tctttatcgt tatgccgcaa gcgcttcgcc 2311501 gcatggttcc gcccatcgta agccagttta tttctttatt aaaagataca tcgctcgctg 2311561 ttgtgatcgc cctgcctgaa ctgattcaca acgcgcaaat tattaacggc caaagcgctg 2311621 acggcagtta ttttttcccg atctttttac ttgcggccct tatgtatttc gcagtcaact 2311681 acagcctttc actcgcagca agacgcctcg aggtccggca aacatagaaa aggatactct 2311741 ttggagagta tcctttttgc attaaaacat tttcgtaatt cttcttctca tccgcttcat 2311801 gcttcgatta ttcagcatgt cagattgagt cgccattcgg tacacgagag ctccggctcc 2311861 cattgccaaa agagaagtca tcgtccgatt catcctgcgc atctcctttc atgattaaaa 2311921 attgatgctg cgttcatcct cagaaaacaa atcatccaag ctgcttaacg ttccgtcttc 2311981 ttccacctga tgagttgcaa tcttcccttt cgccactgtc agttcaataa aacagcccca 2312041 gcaataatat tggttcacgc cgattttgcc gatatcctta cttttgcaat tcgggcatat 2312101 aagcatacct cacacctcta tccgttcaga acgatctcgt ctttccgcac ctcgacaagc 2312161 gaatccgctc tttggatctg gcgcttgctt cccgccaggt cagaaaagaa accgtccgag 2312221 agttcatatg ctacgattat gcccctgtcc aaacaaaagt atacatcttc cagcatcccc 2312281 aatatatccc cctcttgcga tttcacaagc ttcatcttca tctgctcgta tgtgaagcat 2312341 gatttcggaa gaggcaaaag ctgttctgaa ctgaccgaag ccaatatgcg gtcatcaaaa 2312401 atggaagaga tatcacacgc ccgtaatagc gcatgatgat gatgcaaaaa gcgtttttgt 2312461 gcaagaataa acccaagaca atctcctttc agagaaaaac aaatatcgga aattgtcccg 2312521 agataactag aagttcgttc tgagtatact gggaatcctt ctacttcatg gcatgttctc 2312581 aaagtgtgat caaccacctt ttgttgaaca ggcttaggtt ttgctttgcg ccttagactc 2312641 atacgatgaa atcaattcca ctgcaaatga aaaaaaactc ccgcttgcac gggagcattt 2312701 tattgctgtt cttctttcat aaaatcgaat ggtgtaatgc cttccatgcc aatgttggcg 2312761 tcgtgtacgc tgaacgggag ctctttttgc aaagcttcaa gctcggcatc catttcctca 2312821 acctgtacgg acagcctgtt tttcaaggag gtctgtctga cagttgcatc attatttttc 2312881 acgccccact ccagcgcctc ctcttccccg cataaaatga gaaatttctt cgctcttgta 2312941 atcgcggtat aaagaaggtt tcttctgagc attctataat agcctttcac aacaggcaaa 2313001 accacaatcg gaaattcact tccctgcgat ttatgaatag aacagcaata cgcatgggta 2313061 aattgattaa aatctttttt cgtaaatgtc atttcattgc cgtcaaaaga aacgacggcc 2313121 atgtcttctt tttctgtatt ttcctttgca taaaatatcg acgtgatttc gccaatatct 2313181 ccgttgaaca cattgttttc cggctgattg acaagctgca aaattttatc tccggttctg 2313241 tagacaacat ccccgaactt caattctctc cgtttttctt taggaggatt taaaatgtcc 2313301 tgcagcatca cattcaattc attaatgccg gcttttcctc tgtacatcgg agcgaggacc 2313361 tgaatgtcct ttgctgtata gccttttttc aatgcattgg cgacaacctt ctcaactact 2313421 tctttgattt gcgacccgcc gcagcgaata aaggaacggt cctttgtcgg ggcagtcaaa 2313481 ttgttcggca gcaatccatt tttcatctgg tgggcaagct cgacgattga tgacccttct 2313541 gcctggcgat agatgtctgt cagtctcaca gtcggaatca cctgggatgc cagcaggtct 2313601 ctgagcactt gtcccggacc gacggaaggc agctggtctt cgtctccgac aatgatgatt 2313661 tgtatatgat cagggatcgc cttgaacaaa tgattcgcca gccatatatc aagcatactg 2313721 gcttcatcga taattaacag cttcccttcg atcggctgat cctctgtatg agtaaagcct 2313781 tcagcgccgt tccagccaag cagcctgtgt atcgtaactg cagggagtcc cgttgattca 2313841 ctcatccgtt ttgctgctct ccctgtcgga gcggccaaaa caatcggaaa agcttcatcc 2313901 tttttataag ctgacgggtc tagtgacaca ccgtgaagct ctccgtagag ctcgacaatc 2313961 cctctgatta ccgtcgtttt tcctgttccc gggccgcctg ttaaaagaag catcggcgag 2314021 gaaagggctt tttgaatcgc ttccttctgg ctgggggcat actgaacgtc catccgttct 2314081 tccagttctc ccaacgcgag caaaaactct gattcgggaa actggttctc atattcggtt 2314141 tggctagcga tatgtttcac acgctttgca acgttttgtt ctgcgtaaaa cagcgaagga 2314201 aaataacagc ggccatcttc tatgacaatg tctttatttt ctccaagggc aataattgcg 2314261 ttagcggcat ccatttctgt aatgcgctgc ccttcccttg ctgactggtt taacagtgat 2314321 tgagtgtcga tgatcagctg ttccgtttct atgtacgtgt gcccctctga cagacaagtc 2314381 gtttcaagcg tgtacaaaat agcagctttt acccgctcag gatgattacc cgaaagaccc 2314441 attctgctgc ccagctcatc cgcttttcca aacccgatgc cttctacatc cttcacaagc 2314501 tgataaggat tttcctgaat cttttcaagc gtctcggatt cataggcttg atagattttc 2314561 atagacagct gcgggccaaa gccaaactga ttcaaggaaa tcatgatttg ctccagtccc 2314621 tgatgccgct gcaatgcgcc agccagcgtg tctgctttct tttttgagag tctgggaaca 2314681 tcataaagca ctgaagcatc agccaatatt ttattaatgg cgctgtcgcc cagctttttc 2314741 acaatttctt cagctgtttt tttgccgatc ccctcgaata aatcactcga taaatattga 2314801 atgatgcctt ccttagtcgt tggaatctcc tttttgaaat gctccgcctg aaattggagc 2314861 ccgaattttg gatgggttac gatctttccg taaaacgtgt aggtctcttc ttcttgaagc 2314921 gcagggaagt agcccgtcac ggatacggct ttatcttcaa tggcttcgga ggtctctgtg 2314981 actttcactt tcagaaccgt atataaattg gtgtcattat gatagatgac tgtgttgact 2315041 gtccctttta aatagggctc ttcctccagt ttaagctgat ccggatgctg ctgcacgagc 2315101 tgtccctcct cctgtgcctg ttatgatgga tcaatcagtt ttttagcatg aagcgcaagc 2315161 atatgatctg gctggatatc gattgccttg tccagcattt ccagcgcttt ttctcggttt 2315221 tctttataag cataagtgac accggcatta taaaatgcat ctgcatgccc cgggtcttgc 2315281 tctgtcacag ctgcgaattg gctgagcgct tcgtccagca tgccctcgtt ggctaagcac 2315341 atcccgaatt gaaaacgcgc ttccgtatcg ttttcattca gttcgactgc tctttgtaaa 2315401 tatggcagtg caagcttagg ctgttcgagc ttgacaagta ccgttccgag catgtaaaac 2315461 aggtcgccgt tttccatccc cgcacgtagc gctttttcaa acatgtcttt cgcttctttg 2315521 tacatttctt ttacaacata gacatttcct gctccataat aagcagtggc tgcgctactg 2315581 tctaattcaa gcgctttatc ataaaacgca agcgcacgtt ccagctcgtt tacggatgaa 2315641 agaaggttgg caaaattgat atacggaatc gcgtcttctt tattttcttc aatcgctttt 2315701 gtaaatgcct ctgccgcttt ctcgtaatcg ccttcctgca tcgcctctat accgagttga 2315761 ttataatcca ccgatcatct tcctttcatt aaaaaacccc aactcagtgt tgaggttttt 2315821 catcttttat acgtaccaca attttgttcc gtctttgtac acatcatcaa ttgtcccgcc 2315881 gccaaggcat tcttcgccgt catagaagac aacggcttgt cccggcgtta cagcgcggac 2315941 ttgttcatca aagatgactt ccgcttcacc ttcgccagtc atgcgcactg ttactttatg 2316001 atcctcttgg cggtaacgga atttagccgt gcaggaaatc tcttcgccct tcatgatatc 2316061 cgaacgtacc cagctgatat ttgttgctgt gattttgtcg gaatataaaa gcgggttatg 2316121 gaacccttga tctacgtaga ggatgttctt ttcaagatct ttgcctaccg caaaccacgg 2316181 ctcgccgctt ccgccgatgc caaggccgtg acgctgtccg atcgtatagt acatcaaccc 2316241 gtcgtggcgg ccttttactt cgccgtccat cgtcatcata tcgcccggct gtgcagggag 2316301 atattggctg agaaacgttt tgaagttgcg ttcgccgata aagcagatgc ctgtactgtc 2316361 ttttttcgtc gctgttgcaa gttctgcttc tttggcaatt tcacgcacac ggcttttttg 2316421 aagttcgccg atcgggaaca tgactttgct cagcgtatct tctgtcagct gattcaggaa 2316481 gtacgtttga tccttgtttt catcaatgcc gcgcagcatt ctgacttttc cgccgcttct 2316541 gtctactctt gcatagtggc cagtcgctaa atagtcggcg ccaagtgaca atgcatgctc 2316601 caaaaaggcc ttgaatttaa tttctttgtt gcacaataca tccgggtttg gtgttctgcc 2316661 tgctttatat tcatcaagga agtattgaaa taccttctca taatattgct tttcaaagtt 2316721 tacggcataa tacggaattc cgatttggtt gcagacgcgg atcacatctt cataatcctc 2316781 tgtcgccgtg caaaaaccgt tttcgtccgt atcatcccag tttttcataa agattccgat 2316841 tacatcatag ccctgttctt ttaacagcag ggccgccaca gatgagtcta ctccgccgga 2316901 catgccgacg acgactcttg tatcctccgg ccgtttttcc atttcattca ctccaattac 2316961 tacgccgcct tattatgtca gccgtttgac aacgtcggcc acatgtttgg cagcagtttt 2317021 cacttgctca gccgtattgc cgaggccgaa gctgattcga atagaggacg tcagccggtc 2317081 actctcttcg ccgaacatag cagtcagaac atgtgacggc aggactgaac cggccgtgca 2317141 cgctgaaccg ctggagacag cgacaccagc catatcaaga ttaaccagca gcgcttccac 2317201 tgacacaccg gggaaataaa gattcagaac atgcggcaga ctatgctctt tgtccccgtt 2317261 gacctcgaat gccacacctg catctctaag cgtgtcggca aagattgctt taaacgattg 2317321 atacttctcg tttttttcgt cacgttcttc acttgacagc ttgatcgctt ctttcagccc 2317381 gacaatgcct ggaacatttt ccgttccggc acggcgtttt ctttcttgct ctcctccgaa 2317441 taaaaggggt gaaagcttca catctttact agcatataaa aagcctgtcc cttttggccc 2317501 gttgagcttg tgcccggaaa cagacagaag gtcaatatgg ctgtttttca catcaattgg 2317561 cagcaacccg aatgcctgaa cagcatcggt atgaaaataa gctttgtgtt cctttaacag 2317621 ctcaccgatt tcttcgatcg gctgcactgt tccgacttca ttatttccat acatcactgt 2317681 cacaaggatt gtatcatcac gcagtgcttc tttcacctgt tttgcactga ctcttccatt 2317741 ttggtcaacg tccagatacg ttatgtcaaa tccgtctccc tcaagttttt cacatgtgtg 2317801 aagcacggcg tgatgctcaa tttttgttgt gatgatatgt ctgccaagat cttttcttgc 2317861 aagtgcggtt cccatgatcg ccaagttatc agcttccgtt cccccgcttg taaaaatgat 2317921 ctcctgctct gccgctccga tttctgctgc gatctgcgct cttgcttcat ccacccattt 2317981 tcgagattct ctgccaaatg aatgaatact ggagggatta ccgaaactgc cggagaagtg 2318041 cggtatcatt tgttccagca cgcgctcatc catcggagac gttgcggcat gatctaaata 2318101 aatccgttcc attatgttta cacctctgat ctaaatatag aacatataag cttcttgctc 2318161 tccgtctgta tagctggcaa gatcctctaa tgttgtactg tctaaaacct cttttacagc 2318221 atcccggatg cgaatccaga gctcacgctt ggcaggctcc tcatcttcca gcacttcaac 2318281 agggctgatc ggcccctcaa gcacacggat aatatctccc gcagtaatgg catccggctc 2318341 actgcctaat acatatccgc catatgcgcc tctgatgctt ttcactaaac cggcatttct 2318401 gagcggcgat accagctgct ccaaataatg ctcggacaaa ttattcgtct gtgcgatgct 2318461 ttttaatgaa gtcgggcctt caccgtgctt ttttgcaagc tcgatcataa tggtgagccc 2318521 gtatcttccc ttagttgata ttttcaacat gaacacctct gttatttcat gattttccac 2318581 atttataatg gtaatttcta tatgtttcgt ccgtttatta tcttatagac caactgttat 2318641 tataacatac cttcagcgaa ttttcattga ggcagaagga aaggggcctt tacccttttc 2318701 taatgtacgg ttttccgtta ccctgtaatt aagtaaggag agatgataga tgaagccatt 2318761 ggcatatcgg atgcgtccga caaaaataga ggatattatc ggccagcagc atctggtggc 2318821 tgaagataaa attattggca gaatggtcca ggcaaaacat ttgtcatcca tgattttgta 2318881 cgggccgccc ggaattggaa aaacatcaat cgcaacagca atcgccggtt caacaagtat 2318941 tgcttttcga aagctgaatg ctgtcattaa caataaaaaa gatatggaaa tcgtagctca 2319001 ggaagccaag atgtccggcc aagtgatttt gattctggat gaagtccaca ggctggataa 2319061 aggaaaacag gattttctat taccctattt agaaaacgga atgatcattt tgatcggagc 2319121 aacgacggct aacccgtatc atgccattaa tccggcgatc agaagccgga cccagatttt 2319181 tgagcttgaa ccgttaacac ctgaactgat taaacaggca ctggaacgtg cgctccatga 2319241 tgagcatcgg ggccttggca cctattctgt atccattgat gatcaggcga tggagcattt 2319301 tgcccacgga tgcggaggag atgtccgctc cgctttaaat gcgcttgagc ttgccgtgtt 2319361 gtcaacgaag gagtcagcag acggtgaaat tcacattaca ttagaaaccg cggaagaatg 2319421 cttgcagaaa aaaagctttt ctcacgataa agatggtgac gcgcattatg atgtactgtc 2319481 cgcttttcaa aaatcaatcc gcggctctga tgccaacgct gctcttcact atttggctag 2319541 attaattgaa gccggtgatc tggagagcat cgcaagacga ttgcttgtta tcgcctatga 2319601 ggatatcggt ttagcaagcc cgcaagccgg ccctagagtg ctgaacgcta ttcagaccgc 2319661 tgagcgagtc gggtttcctg aagcgcgaat cccgctggcc aacgcagtta ttgagctttg 2319721 cctctcaccg aaatcaaact ctgccattct ggcaatcgat gaggccctgg cagatatcag 2319781 agccggaaaa attggggatg tcccgaagca tttaaaagac gcgcattata aaggagctca 2319841 ggaattagga agaggaatcg actataaata cccgcacaat tacgacaacg gttgggtcga 2319901 acaacaatac ctccctgatc ctctgaaaaa taagcaatac tataagccga aacagactgg 2319961 aaagttcgaa tctgccttaa agcaggtgta cgataaatta atgaaaagaa aataaaacaa 2320021 aaaaacagcc ttgatcatca aggctgtttt tatgcattat ttatccttca cacgtttgat 2320081 ttcaatgtct ttcaaaagat ccatgacaac atgtccgccc ataatcaaac ctgcaactga 2320141 cggcacaaaa gcattagagg aaggcggcat ttttgcttta cgtattttcg cttcgtcatt 2320201 ccccacttct tttctgacat cttcccgaat aacaatcggg ctttcatcag agaaaatcac 2320261 ttgaacgcct tttttgatac cctccttgcg taatttcgta cgaacgacct tcgcaattgg 2320321 atcagtgtgc gtttttgaga tatcagcgat ttggaagcgt gtcggatccg ttttatttgc 2320381 agcacccatg ctggagatga gcggaatatc ccgttttaga cattctttca ttaaatgaat 2320441 tttataacaa atggtgtctg acgcatcaat gacatagtca agaccatagt caaaaaactg 2320501 ctcatacgtt tcctccgtat agaacatttt taacgcgatc acttcacact ccgggttaat 2320561 gtctgcgatc cgcgccttca ttaaatcaac tttcggctgt ccgacagttg aaagcagcgc 2320621 gtgaagctga cgatttacat ttgtaatgtc gacatcatct ttgtcgacaa gcagaatgcg 2320681 gccgacgcct gaccgcgcga gagcttccgc cgcgaacgac ccgactcccc cgactccaag 2320741 cacagcaact gtgctgtttt tcagcgtttc aaggccttct tttccgatag ctaattcatt 2320801 gcgtgaaaac tggtgtaaca agaacctcac tccacattcg tattctggtt tcatctataa 2320861 aatggctgat ccatgagcag ccgttttttc tgcgcacaaa aaataaagtc ccaatagtgc 2320921 cgttgcagct ttcctttgtt ttgaacccgc tctcagcagg tgggtgccct cttttaaatc 2320981 ttgtaagtcc tctttaccga atgaaaagag gcatgtacgc catttaaaaa tgcgggctcc 2321041 caaatcaaaa aaatgttcgg tcaaaactag gtgtacaact aacacatcag gactttattt 2321101 aacttgtcaa aatcatatca cagacgattt tgattttcaa gaatcgaact gcaaattcag 2321161 ttcttaactt ttttcttgat agaaagatga agctcgtcaa gctgggcgtc gcttacttcg 2321221 cctggcgctt ctgtcatcag gcagcttgca cttgccgttt tcgggaatgc aatcgtatct 2321281 ctcaggttcg tacgtccagc gagaagcata acgagacggt ctaagccgag tgcgattccg 2321341 ccgtgcggag gagcgccgta ttcaaatgct tccagcagga atccgaactg ttcagccgct 2321401 tcttctggtg agaagccgag aagcgcaaac attttttcct gaatatcctt ttcgaaaata 2321461 cggattgaac cgccgccaag ctcatagccg tttaagacga ggtcataagc ttgcgctttc 2321521 atgtcttcag gcgctgtttc aatcagctca aggtcttctc ggacaggcat tgtgaacgga 2321581 tggtgcgctg cgtaaaaacg gccttcttcc ggatcatgct ctaatagcgg ccagtcgatg 2321641 acccataaga aattgaacaa tttttcgtca atcagtccgc gttctttccc aagctttaag 2321701 cgcagggcgc cgagtgatgc ggccacaact tcgaattgat ccgctccgaa cagcagcaaa 2321761 tcaccttcag cagcatcaag tgcttcaatc agcttagact gcttttcttc atcaaagaat 2321821 ttagcgatcg ggcctttcac tccgtctgcc tcaaccttca cccaggcaag cccttttgcc 2321881 ccgtagtttg cagcaaaagc gccaagagcg tcgatgtctt ttctggagta atcgccggca 2321941 ccgcctttta cattgatggc tttgaccacg ccgccgtttg ctacagctga tgagaacact 2322001 ttaaattccg tatcctttac aatgtcagac acatccgtca aaagcatgtc aaaacgcgta 2322061 tccggtttat cagacccgta cttgttcatt gcttcgtcat acgtcattcg aggaagagga 2322121 agctgaagtt cctcaccttt tgtttcacgc ataacctttg ccatcatctc ctcagccaat 2322181 gacataatgt cttcctggct cataaaggac atttcaatat caatttgcgt aaactcaggc 2322241 tgacggtccg cacgcaagtc ttcatcgcgg aaacagcggg caatttgata atatcgttca 2322301 atgcctgata ccatcagaag ctgtttaaat agctgcggag actgcggcag cgcgtagaac 2322361 tcaccttcgt gcacacggct cggcaccaag tagtcacgtg cgccttcagg cgtgcttcct 2322421 gttaaaatcg gcgtttcaat atcaagaaac ccattttcat ctaaaaagct gcgaacagct 2322481 ttcgtcacgt tatggcgcag ctgcatcgtc tggaacatag ccggtctgcg caaatctaag 2322541 taacggtgtt ttaaacgaac gtcctctgac acttcttcag cttgatcaga aatcgcaaat 2322601 ggaggtgtct ttgcagcatt taatacgttc actccatcag catgtatttc gatcgcgcct 2322661 gttttcaaat tcggattaac tgttccctct tcacgcgcca ccacttttcc ttgaatatca 2322721 agcacgtatt catttctgat gccttccgca atagcaagcg cttcttttga cacatcaggg 2322781 ttaaaaacga cttgaacaat gcccgtacgg tcacgcaagt caataaaaat caatccgccg 2322841 aggtctcgtc ttttttggac ccagcctttc agcgttacag attcgccaat tgctttttca 2322901 gttatatcac cgcaataata tgttcttcca aacaatgcgt ttcactcctt atcccttttg 2322961 gtttgccttc atcacatgta taaattcatc aagtgccact tcaatctgtt cgcccgtctg 2323021 tgcatccttt acattgattt tgttttgggc aagctcatct tcacccaaaa tcgcaataaa 2323081 tctggccttt aagcgatcag ctgttttaaa ctggcctttc attttcttat tttcataatc 2323141 gatttcactg gaaatgcctg cttctctcag tttgtacacc aatgaaacag aataatcctt 2323201 tgctttttcg ccgagtgtga cgatatagca gtcgattccc ttatcaacag gcagctctct 2323261 tttttcagca tcaattgcgg caagcaagcg ttcgatgctc atcgcaaatc cgatgcccgg 2323321 tgcttcaggt ccgccgatct gttcgacaag cccgtcgtag cgtccgccgc cggcaagtgt 2323381 cgtaatcgcg ccaaagccct ccgcattgct cataatttca aatgcggtgt ggttgtaata 2323441 atccagccct ctcacaaggt tcggatcgat ttcatacgaa atgccaagat catttaagta 2323501 ttgtttcact ttttcaaaat aagcggctga ttcttcattt aaatatgtca aaatcgaagg 2323561 tgccgatttc atcagctcat gatcacggtc ttttttgcag tccaaaattc taagcgggtt 2323621 cgtgtgcagc cgggactggc agtctgaaca aaattcttcg atgcgaggct cgaagtgttt 2323681 cacgagcgct tctctgtagc ttttgcggct atcttgatcg ccgagactgt ttatgacaag 2323741 cttaacgttt tctaaacctg ctttttcata aatactcatc gcaagcgcca ttacttcagc 2323801 gtcgattgca gggtctttcg aaccaatcgc ttcaattcca aactgataaa actggcggta 2323861 acggcccgtc tgaggacgtt cataacggaa catcggcccg acataataaa gctttgtcgg 2323921 ctgtacagga tttgcgaaca gcttgttttc attaaaagcg cgaaccgcag cagctgttcc 2323981 ctccggacga agcgtcaggc ttctgccttt gcggtcctcg aaggtataca tttctttttg 2324041 tacgatatcc gttgattctc cgacgcctct ggcaaacagt tctgtatgct caaaaatcgg 2324101 tgtgcggatt tctttatatt gataagtgcg gcaagtgtct ctcataattt gttcaacaaa 2324161 ctgccagcga tctgattctc caggcagaat atcctgtgtt cctctcggaa tgttatatcc 2324221 cataggtaga cctccttatg tattccttat aaaatatcca atgatcgtta atgatgaaaa 2324281 tgaaaaaaac tcccgcccct actatacatg atagtaggga cgagagttat acccgtggtg 2324341 ccaccctagt tggaatacgt tcatattccc gctcgatcct ttaacgcagg ttcacgttca 2324401 ctgcctaatg gcgttattca cgcgttcagc aggaaacctc cggagtgttg tttcgagaaa 2324461 gacgcaatgg gatccgcttt cagcctgggg cgggttcctc tctaatcatg caatctgacc 2324521 tactcttctc cattattggt tcaaatcttt catcatttgc tatgtactca atttctatta 2324581 taataatggg attggggttc tctgtcaagc tttattccgg ttgtttttcc tcagcgctgc 2324641 ttctttggac ataagaccaa attcagatgc tgtttccgta agataaccag tcgtatcggg 2324701 atctgcgtga tcgctgtaat gcagattcgc ttcaccgtcg tgaaatgcac gtcccatttt 2324761 tggatgatat ttcatgattt gcacaccttt ttgattgtat ttacgcttag tataaacaaa 2324821 tcattttatt tttatttaaa aatcagaaag gactttacga tattaaacaa gaatgctttt 2324881 ttaatgatca tcagaaagga ggacacaatg aacaagaaat actttgtcct tattgtatgt 2324941 attattttca cctcagcgct attcccgacc ttttcatccg ttacagctgc tcaaggagaa 2325001 gcggtcatcg caacagatga aatgaacgtc agaagcggcc cagggcttag ctacggcatt 2325061 acagcggaag taaaaaaggg agaacgctat ccaattttaa aggaagatgg agactgggtg 2325121 cagatacagc ttggttctgg agaaaagggc tgggtagtct cctggcttat tacaaaggaa 2325181 gaccaggcca gcacaagctc ctcaggaagc agtgacactg tgacatcaac agaccccgat 2325241 ctgcggatga gaagcggccc gggcacttcc tacgaagtca tcggcaaatt cccgcaaggc 2325301 agccaagcat ctgtcattga taaagattcg ggctggatca agatatccta tcacagtgcc 2325361 accggatggg tatcatctga atatgtcaca tcaggaggca gcagttcagc gtctgatgag 2325421 agtgaccaaa ccgaggattc cggtgcgtca acgacgggca cagtcggtgt ttcttcgcta 2325481 aatgtaagag cctccgcctc acatgacgcg gcaattataa caaaacttga tcgcggaacg 2325541 aaactgacgg ttctcaacga gaaaaatggc tgggctcaca ttgaggtgaa cgggctaaaa 2325601 ggctgggttg caagccatta ccttttgact agttctgttc cagctgatga ttcagcaaat 2325661 gccggcagtt catcctccgc taaaaaagcc tatatcatgt acggaggaac gaatctaaga 2325721 agtgatgcgt caacatcagc ttcgatcgtt gagcgcgctg ccaaaggaga ttcatacacc 2325781 attaccggtt caaagggaag ctggtatgaa ataaagcttg ataacgggca gactgcttat 2325841 gtagccaatt gggtggtcca aacgtctaaa agcgcagaag aagcaggtga accgccagtc 2325901 tctgattccc cgtctggaaa cggctctcta aacaataaaa cgattattgt tgacccggga 2325961 catggaggaa aagacagcgg aacgatcggg tattcgggga aattcgagaa aaacctgacg 2326021 atcaaaacgg caaaactgct cgccagcaaa cttagatcgg ctggagcgga tgtatatgtg 2326081 acacgccagg atgatacctt tgtcagcctg cagtcacggg tctctacctc tcactaccgt 2326141 aacgctgacg cctttatcag cattcattat gacagctatg cggatacctc tacaagaggc 2326201 agtacagcat attactacag tcctgccaaa gatcaggaac tcgcatcaga tgtccactca 2326261 gaagtggtga agcgttcttc cattccagac cgcggcgtat tattcggaga ttattatgtg 2326321 ctccgggaaa acagacagcc cgctatgctg tacgagctgg gatatgtaag ccatccgcag 2326381 gaagaagcca ttgtacatag caattcatac caagaaaaag taacagatgg gatcgaaagc 2326441 ggattagaga aatacttcca ataaaaaaag ctgccttttg gcagcttttt ttattttgaa 2326501 tccataatga gcgtgaccgg tccggagttt gtaagctgaa catccatcat tgctccaaac 2326561 gttccggtct ccactttgat tcctttttca cgaagcaggt cattccattt ttcataaaga 2326621 cctaaagctt tatcaggttt ggccgcgttc atgtagttcg gccggcgccc ttttttcgta 2326681 tctccataaa gcgtaaactg tgagacggat aaaatctctc ctcctatatc tacaagagac 2326741 agattcattt tcccttcact gtcatcgaaa atacggagat tgacaacttt atcggctaaa 2326801 taagctgcat catcttctgt atcatcgtga gtgatgccga ccagcaccat aaggccttgt 2326861 ccaatttggc cgacgacctc ttcgtccact gtaacgcttg cttctgttac tcgctgaaca 2326921 actaatctct tttctaaccc ctttagttca tgacgcggcg cacagaatag atatctctaa 2326981 tctgtttaat acgctcgacg actttatgca agtgattgat attctggata aaaatcgcca 2327041 tatggatggt tgccacttta ttgcgatccg atttgccaga gacagatgaa atattggttt 2327101 tcgtttcatt cactgcctgg agtacctcgt tcagcaatcc gcggcggtca tacccaagaa 2327161 tctctatctc aacattgtat tccttgcgct tttgaacttg tgactcatgt tcccactcta 2327221 ccgggatcag ccgctcttgg gcttcattcg ttttgacatt cggacagtct tcgcgatgga 2327281 ccgaaacccc tctgcctttt gtgataaagc cgacaatatc atcacctggc acaggattgc 2327341 agcattttga taaacggaca aggaggttgt caatgccctt gacacgaacg ccagcttccc 2327401 gttttcttcc ttgcgggtat ggcttaggtt ccccagtgac ttcctgaacg atcttttcct 2327461 gttcttcctg gtcgcgctgc tttctctctt tttctgttag gcggttcgcc acctgcagag 2327521 ctgtgatgcc gttgtaaccg accgccgcgt acatatcctc ttcatttgag aaattaaatt 2327581 tgtcagcaac cttttgaata ttctccggcg ttaaaacatc cttcaattca aaatccaagt 2327641 ttttaatttc tttttcgacc agctcacggc ctttttcgac attttcttca cgccgctgtt 2327701 tcttaaagaa ttgacggatt ttatgcttcg cttgggatgt ttgggcaagc ttcacccaat 2327761 cctggctcgg accgtaggaa tgcttagagg tgagaatttc aacgatatca cctgtccgaa 2327821 gcttatggtc aagcgtaacc atttttccgt ttactttggc accgattgtt ttattgccga 2327881 tttcagagtg aatccggtaa gaaaagtcaa tcggaacaga accggacgga agctcgatta 2327941 catctccttt tggcgtaaag acatacacca tgtcagagaa caaatcaatt ttgagcgatt 2328001 ccataaattc ttctgcatct gtcgattcat tttgaaattc taaaatttca cggaaccaag 2328061 aaagcttttt ctcaaaggtt gcaccttcat tggctgcttt cccttcttta taagcccagt 2328121 gagccgcaac cccgtattcc gctatttcat gcatttcaaa ggtgcggatc tgcacttcaa 2328181 gcggatcgcc tttaggccca ataaccgttg tatgaagcga ttgatacata ttcggcttcg 2328241 gcattgcgat ataatctttg aatctgcctg gcatcggttt ccagcatgtg tgaatgatgc 2328301 caagcaccgc gtagcagtcc tttatgctat tcacaagaat acggacagcc aacaaatcgt 2328361 aaatttcatt gaattgctta ttttgcagca ccatttttcg ataaatgctg taaatatgtt 2328421 tcgggcgtcc cgagaagtca gccttgatat ttacttcttc gacacgtttc ttcacttcat 2328481 tgacaacctc atcgacataa agctctcgtt ctgcacgttt cttcttcatg aggttgacaa 2328541 ttctgtaata ttgctgaggg ttcaaataac ggagcgccgt atcttccaat tcccacttaa 2328601 tttttgaaat cccgagacga tgcgccaaag gagcaaaaat ttccagcgtt tcattggaga 2328661 ttctccgctg tttttcctga ggcagatgtt tcagtgtccg catattgtga agacgatccg 2328721 ccagcttgat caatatgacc ctgatatctt gagccatagc gacaaacatt ttgcgatgat 2328781 tttccgcctg ctgttcctct tgagatttat atttaatttt gccgagtttc gttacgccgt 2328841 ctacaagcat tgccacttct tcggaaaatg cttctttcag gtcatcgagc gtcacatctg 2328901 tatcttccac gacatcgtgc aaaaatccgc ccgcgattgt ggaagggtcc atttcaagat 2328961 caacgagtat ccccgcaacc tgaatcggat gaataatata tggctcgccc gatttgcggt 2329021 attgctcgcg atgagcatct tcagcgtaca gatatgcttt ttcgacaaat gcgatatgct 2329081 catcagatag atagctgcgt gctttatcta taacttgctc ggcagtcaat acttgttcgt 2329141 tcgccatgga atcacctttt ttaaaatgta aactgtattg tagtttatta tcaagaaaaa 2329201 aacgaaagat gtaaagagca gaagttcaaa tagccaaata ttatataaaa taaatgcaaa 2329261 acaataggaa aaaagcaccc tgacatggag tgctttttcg ttatgcggtt atccttagta 2329321 tttcatcaat gttaagatgt cgtaatcttc gagcttattt ctgccgtcaa ggtaagaaag 2329381 ctcgattaag aaagcgatac cagcaacaac gccgccaagt tcttcaacaa gtttgattgt 2329441 cgcttcaatt gtgccgcctg tcgcaagcag gtcatctgta ataagcacac gctgaccagg 2329501 cttaatcgca tctttgtgga tcgttaatac gtcttttccg tattccaagc cataatccac 2329561 tttgattact tcacgaggca acttgccttc tttgcggacc ggcgcaaaac ctacgccaag 2329621 cgcgtaagca acgggacagc cgataataaa gccgcgcgct tcagggccaa cgaccaaatc 2329681 aatttgcttt tctttcgcat attcaacaat ttgatctgtg gcatagcggt atacatcgcc 2329741 tttatccatc agtgtcgtaa tatctttaaa ttgcacgccc tctttcgggt aatccggtac 2329801 aattgttacg tattgtttta aatccatctg ttttatgtcc tcctcgtact ttcataagcc 2329861 tctgaatctt gtttcatcag cttattcagc cattccttca gctcttcagc agaagaataa 2329921 ttcagctttt gatccagttc catcagctgc tgtttcgcct gatatgtttg tgagtctgtt 2329981 aagtcgcgtt tctttgctcc gctcacaaca gacagcacac cattctctat tttaacaaaa 2330041 ccgagatcaa aaaacacctt tgtcatgaaa ttgattgttt caacggacca gcctttatgt 2330101 tttgcaagct ctgaaccgtg ttttttcacg tcaaaagcgc ctcttttcag caagaacgca 2330161 taataccatt taaagtggtc tcttgcggga aaagttgata aaaagtggtc ctcatgattg 2330221 agaaaaataa aatatatccg ctcgggcgcc tttccttcca gcaaacgtgc gagcatgtcc 2330281 agcgaaggcg gcggatccag taatacaata tatgcaccat cgaggtcaaa cgcctttgct 2330341 tgatctttag aactgatgac gtgcacttct cggcgaaggt cttcagtttg aagtaatgtt 2330401 gttgagtctt ctttgaaaga gacaatggcc cgtttagcag atggaagggc ggaaactgtg 2330461 tcttcccacg tccgttttcc ccttaaatca aacagctgcc attcagaaac agcggcatcc 2330521 tttatcataa gctgcggctt ttttcgattg ttccattcgt tgattgacat ctcaccgaca 2330581 atggaaattc ttgaacccgg tacgatgcct tcttgaagct cgcctttatt aaaaccgacg 2330641 caatcaagct gggacgactc gtttctgatc gtcattttga catgagtttt atttgcccct 2330701 atcttgcgga catcttccag tactgcattt tctacgagaa cgtgcggttt cgggttcagc 2330761 atgccaaaag gagacagcat gttcatttct gcgatgcttt caactgtaat gtcttcgacg 2330821 ccgcagacaa ggtcgacttc ctgtacggga ataaaatcct cttccgtaag cgtattgtcc 2330881 gctatttcat tcagcctgct tcgcaaatcc ggcacatctt cggctttcag cgtcatcccc 2330941 gcagccattg gatggccgcc gaaatgagga agaatatctc tgcattcaga aaggctctca 2331001 aataaattaa atcctctgat gcttcgggcc gaacctttag cgattccctt ttcttcatca 2331061 ataccaagaa caatggccgg tcggtagaaa cggtccacaa gctttgaagc cacaatcccg 2331121 acgactcccg ggttccatcc ggctttggcc acgacaattg cagtttgatc gagcccttgc 2331181 tgttcaacca tttcaatcgc ttcatccgtc attttgctga ccattttttg gcgctctttg 2331241 ttcagctggt caatttctgc ggcaagctct tccgcttcaa acgaatcctc tgacataagc 2331301 aaatgaacag cgggatccgc ctgttcgatt cttccgacgg cattcagcct tggtgcgagc 2331361 tgaaatccga ctgtttcttc gttcgcttct ccgatgtctc cgcctgacag cttaatcagc 2331421 tcttttaagc cgagccgatt tgtccgtcga agcctttcaa gtcctagtgt tgctattaat 2331481 ctgttttcgt catgcagcgg gactagatcg gcaatggtgc cgatagccgc caggtcaagc 2331541 agttcatcag gaagttcacc caataaagcg tgggcaagct taaacgcgac tccaaccccg 2331601 gcaagctctt taaacgggta agtgcagcca ggctgcttcg ggtggacgat cgcacggaca 2331661 tccggaagct ccggtcccgg ttcatgatga tcggtaatga tgacatccag tccgagttcc 2331721 tttgccacct tcgcttcatg cacagcggca attcctgtat caaccgtaat gatcaaagag 2331781 aagccccgtt ctttaatcga acgaaacgcc tgttcattag gtccatatcc ttctttaaaa 2331841 cggtcaggta tataaaaatc aacttgagcc gacagttttt gcagcgtgtg aagcatcact 2331901 gacgtacttg taaccccatc ggcgtcataa tcgccatata tcataatctt ttcttgttgt 2331961 gaaatcgcct gttttattcg atctgccgct tctttcatgc ctttcatttc aaaaggatca 2332021 taaaaatcgg catcctttgt atgtaaaaac agcctagcgc tttctgccgt atcaaagcct 2332081 ctttttacaa gcagggacgc aacaagaggt gttatatgca attgttctgt gagtgatttg 2332141 accttatcct gatctggtcg ctggatttcc catcgcattt ttgacgctaa cataaattca 2332201 cccctcaacc accctattat actagagcag gctgaggggt ttcaaataat attcgaaaac 2332261 tagtcttttt tctcaatcat ggctgatgca tcctgtgtgt cagtctgatc agcaagatga 2332321 gtatcctctt gtttatgtat tgctgttcta ttttctttcc gcaaggtttt tatttcccgc 2332381 ttcaatttca ttacctgaaa aatgccgaca gaaaatacga tcagtgctcc cattaaaact 2332441 gagcccaaaa taacaagaat gagcggccat tctgatcttc caaacaggta atcaacttct 2332501 acggatcgaa cattaatgac tgcgaaaata gcgacaatta aggtgaaaat aagtgcgaaa 2332561 ataatggtcc attgtttatt cattctcttt tcccccaaac ttcttattga ggtaactttc 2332621 ccaatcaaga ctggttttaa acatggctta acactaggtt aagctccctt tgctgttaat 2332681 ttttcccgga tcagcctctt cagtccggtt ccctcaccgg aaatcacaag tgtatcgcct 2332741 tcgtcaatga ctgtttcaga gctcggattc agttgtttat cctgattctt tttaacaatt 2332801 gcaatgaccg tcacatgata ttcctgaccc acattcaaat caccaatcgt ctgatgaatg 2332861 gcaggcgctc ccgcctctgc tttacaccac tctataatca aatcatcaag ggctgactcg 2332921 acctgttcta atgctttcgg tttatatgcc attccgccaa gaattgcaga catttgcctt 2332981 gcttcagcgt catcaaactg cacggaggca acacattcct catggtcgtt ttcgtcaaaa 2333041 tagtaaagct ctctccgtcc gtcatgatga atgataattg aaattttatc acggtttcta 2333101 gtaatcattt caactttttg tcctatgccc ggcagctctg attcgcgaac cctcatatat 2333161 aaaccctcct acatatctga aaaccagcca taaacacttt taacaccata tatatgttta 2333221 aatgtaagcg tatgtcatta tagcaaatgt ctattttaag ttcaatgaaa cttcaaaaaa 2333281 caggctgccc tgcagaggac agcctgatat tttttattgc gccgaatctt ttttcagttc 2333341 tcttcctttc catgcaagcc aaatttgtgc ggcaatgtat agagaagaat aaacgcctgt 2333401 taacagcccg accaataaag caattgagaa gttagtaata gaagatgctc caaagatcag 2333461 caatgtcaca acaacaatca caacggttaa tacagtgtta attgaacgtg taaaggtttg 2333521 ctgcaggctc aggtttacaa tatggttcag atcggcaaag gttttcggct tacgcttttt 2333581 catatgctcg cggaccctgt caaatgtaac gattgtatcg ttaatggaat acccgattat 2333641 cgtcaagatg gccgcgatga atgtaacatc tacctcaagc cttgtaatac tgaagaacgt 2333701 gacgataaag aatgcgtcat atagcaatga ggcgatggca gcaatcgcca ttttgtattc 2333761 gaatcggatt gaaacgtaaa taatgatgcc aatagaagct atagcaactg cgtacagcgc 2333821 atttctcgcc agctccttac cgactgtcgg tgaaactgtg ctgacatttg gatcagatcc 2333881 gtatttgtct ttaaaatacg tttttacttt tgcaatggtt tctttatctg gcaccccgac 2333941 aaaacgggca acaccgatat tgctcttttc gcctgacaga actacagtat cagggtccat 2334001 acccagagat tcaaaatcct tctcaacttg ctctgtcgtc agcttatggt cgctttgcac 2334061 ttcaatccgt gcaccgcttg caaagtcaat gccaagattc agcctgaaca caagcaggat 2334121 aataatcccg gcaaccgtga ccgcactgga gaaaataaag aagtatttgc gtttgctcgt 2334181 gaaatcccat ttttggaatg gcgtatgcgg ctctgtattt tcatccgtat cctgaatatc 2334241 catgatatgt ttcttattga caccaaacca gccttttttc cgatcaagcc atctgctttc 2334301 cacaaggaga gcgaggagaa atctcgataa gaaaacggca gtgataaagc ttgtcaaaat 2334361 cgataggatc agcattgtcg caaacccttt aacagagctt gtcccaaaga taaagagcac 2334421 aaccgctgca ataatggttg taatattcgc gtcaaaaatc gtcgcaaatg accgtctgtt 2334481 tcctgaacgg aaggcagagc ggactgactt tcctagcttg agctcttctt taatccgctc 2334541 ataggtaata atgttggcgt caacagccat cccgacacct aaaatgagag cggcaattcc 2334601 cggaagcgtg agtacggcat tcatccagtc aaagatctgg agtgtaatgt agatataaac 2334661 agacagcgta atcaccgcga ttaatcccgg cagacggtaa tagaaaagca taaataagaa 2334721 aataattgcg ataccgacaa taccggcaaa caccgtatca tggagagcct gctggccgaa 2334781 ttgcgcgcct actgatgtcg aatacttttc agtcagtttc acaggaagtg cgcctgcgtt 2334841 taaaatgctg gctaaatctt tcgcttcttg agctgtgaaa tgaccttcaa tttttacatc 2334901 agttgtattt agttcctgac ttacatttgg agcggataca aatttaggat gctctttttg 2334961 aacttctttc ttaaaggaat cacctttatc ataatccaac caaatgacaa gctggttgtt 2335021 tggcgccatt ttcatgacct tcttggtcac ttcaccaaat ttatcagcgt ctttcagctt 2335081 aatcgtgaca attggctcat ttgttgtgct atcataagtt tgtttagcgc cgttttcgac 2335141 tagatcagca ccgtttaaca gttccttatc atttgcatct ctgaaagaaa gctgcgcttc 2335201 agtcgccaaa atttcacgcg ctctgttttg gtttgtcacg ccagcgagct gaacgcgaat 2335261 ccggttattc ccttcaattt ggatgttcgg ttcgctgaca ccgagaacat tggcccggcg 2335321 gttcagtgcc tctactgtgc tgaccagaac gtcttttgtg attttgtcac ctttttttac 2335381 aggctgtaca tcatacagca cctcaaatcc gccttgcaaa tccaatccta acgtaatatt 2335441 gttagcggca ggcttcgtaa agtagcccaa gcccgtgccg atcaatagaa cgaaaaggaa 2335501 aaacgcaatc aagcgtcctt ttttcattat gtatatcctc ccttaaacct gtgcgaatca 2335561 acctgctatc tcagcagttc ttccaatgct tcctggccct cttcactgcc cagccaatta 2335621 gacgttttaa atgactcaac ggttgcatag ttcataaatt cgccaatttt cactgataaa 2335681 atatcactcg ccagttcata aatgctcagt tccgttttct ttttccactt cttatctgtt 2335741 aagtatgacc acaaactttc gagttcaaca tcatcatacc cgagaatctt aaactcttcc 2335801 agtttgctgt aaagaaacgg cctgacgtgg tctttatata gatcggctgg atgcttctcc 2335861 acgaattcca cgctcctttt ttattgtttt tcaagaagac ttgtcatgct tggacgacat 2335921 atacgcatat ctttattgta tatgattcca ggtagtttga gaaggcaggg ggtaaaaatg 2335981 gcgaaacaga cgtttttaaa gggcactctt atccttatcg cagcaggaat ggttacaaga 2336041 atgctcgggt ttgtcaaccg ggtggttatc gcccgtttta tcggtgaaga aggagtcggg 2336101 ctttacatga tggcagcgcc tactttcttc ttggccacta cattaactca attcggtctg 2336161 ccggtcgcga tcagcaagct agtcgctgaa gccagtgcgc gcggagatca tcaaaaaacg 2336221 aaaaatattt tagtcatgtc tctgaccatt acgggagtgc tcagcctcat ctttacaccg 2336281 ctgtttctgt ttttcgcccc tgttatggct gaaacgatgc tgacagataa gcgaacactg 2336341 tatccgctct tggccattac gcctgttgtg ccgattattg ctatatcgag tgtgctgagg 2336401 ggatactttc aaggaaaaca gaatatgaac ccgcttgcta tgtcacaagt ccttgaacag 2336461 gttgtccgca tttcactcgt ggctgtctgc acaacgattt ttctccctta cggaattgaa 2336521 tatgctgcag cgggggcaat gctatcctca gtggcagggg agctggcatc acttctttat 2336581 ttattcgttt gctttaagta taaaaagaca attaaaatca gaaagcattt tttacagtca 2336641 attaaaaacg gaaaacaaac ctttacccaa ttaatgagcg tgtcccttcc aacaaccggg 2336701 agccgcttta tcggaaacct ctcttggttt ttcgagccaa tcgtcgtcgc tcaaagcctt 2336761 gccatcgccg gtgtggcaac agttgccgca acaaagcaat acggggaact aaccggcttt 2336821 gccatgacgc tgctgactct gcccagcttt attacatatt ctttgtcgac cgcgcttgtt 2336881 cctgcgatca gtgaaggaat ggagcagaaa aaattgcagg tggtggaata ccgcttagaa 2336941 caggcgatgc gtctctgtct gctcagcgga ggcatttcag ttgttatttt atttgtattt 2337001 gcggatgagc tgatgagagt gatgtacggt tcctcaggcg cagctgtatt tataaaagtg 2337061 atggccccgt tttttctgct ttattatttc caaggcccgc ttcaagctgt gctgcaggcg 2337121 cttaatttgg caggagctgc gatgatgaac agcttaatcg gagcgcttgt caaaacaggc 2337181 cttatttttg tccttgccac aaggccttct cttggcatta tgggcgcggc attagccatt 2337241 gtgacaggca tggtgctcgt cacgctattg cacgcagcaa ccgtaagcaa agtgctgccg 2337301 atcagcatca aaatcaagga gtacgcgctc agcttcgctg ttattgtaat ttgcggattc 2337361 atcagctccg ccatcaaaca atatataagc tttggagcat ctgaggctgt caatctagcc 2337421 ggatggattg cggcgagcgc cgccatttat atgatcctcc tgctcgtttt ccgtttaatt 2337481 aaaaaagatg agcttcgccg cattcccatt atcggacggt tgatcatccg ataatggtca 2337541 cgtgcggtgc ccatcttttt catcaatata tatttctccg tctgtaaacg agcaaaatga 2337601 aatatctgaa gggtttgtgt atccgtgttt ttgcaaactt tcaagcagcc attttctatc 2337661 tttactgatt ctggacaggt tttctgtttg aatgaagccg tctataatga gcggcatttc 2337721 gagctgccga tgctctccgc tgttttcttt cttaacaata gtcagtttgc ccgacggctc 2337781 taaaatagca aatgatacgt cagctactct gtcgatgcta ttttctctga gctgaaccat 2337841 taaatcatca aaattataac gctgtgattt catggcttct tcgtcaattt ttccatattt 2337901 gataattatg gtcggcttac cgtcaagaag ctggcggact tttcggtttt ttaaagaaaa 2337961 gtatgccaaa gtcacttgaa tgatcattaa tacaagcatt ggcaaaatgg tatgaaatag 2338021 atgatcgtct acgttttcta tggctaaaac ggcaatttca gccatcatga taaagacaac 2338081 gagatctaaa atactaagct ctccgatctc ccgtttgccc atgaaacgaa aaatgaccaa 2338141 tatcacaaaa tacaatacga ctgtgcgaaa cgcaatagtg agaagctctt ccattatgca 2338201 cctccaactc attataggtt gcaacaaaat gatcaattta tgtaagaaaa accgattgca 2338261 tttcacaaag cttttacgtc taattcatgg gataagggaa tacattttta caaagacgag 2338321 ccatcagcat gtctgacggt tttgaacaaa aagaacagaa gccttttaat acaggcagag 2338381 aggagacaat catggaggaa acgaaacaag ttggaaaagg cattctttac ggcttaatcg 2338441 ccatattttc agccatgctc ctgacaagtt tagcggtttc acttttattg accgcaacct 2338501 cgctggaaga atcatcattt aactggctga tcaccgctat ctcatttctc tctttattta 2338561 tcggcgggtt catttcaggc gggaaaggca aggaaagagg ctggatgatt ggcgcattga 2338621 ccgccttaag tttttctctg attatcttat tgtttcagta tttaggattc ggaaagacat 2338681 ttacagcaga acagctgatc ttccatctgg gatttttagg ggtgtgcatg ctgggcggga 2338741 ttttcggcgt gaacatgagg ggaaacaggt cttccacata aaaaagagcg ggctcacttg 2338801 cccgctcttt tttgtttgct atgtatagct cctgctgtta ttcagcagca gaaacttctc 2338861 tgatcgcgcg gcggtcgaac gtaagacgtg tgttatcacc agtcttaatt acgactttgc 2338921 tttcgtcgat agagtcaaca gtaccgtgca atcccccgat tgtcactact gaatcgcctt 2338981 ttttcagttc ctcttgcatt tggcgtacag ccttttgctg cttttgctga ggacgaatca 2339041 gcaagaagta aaggaccgca aacattaaaa taataggaac caatgtacct aaagtgccag 2339101 tcatcatttt cacccctttc tgtaagcctg ttatgtttat ttagaagctt ttcgcatttg 2339161 gcttgttata gccgtaacgc tcaaagaact cttctctgaa atcacccaga cgatcctcgc 2339221 gaatagcctg tcttacctgc tccattaagt gtaacagaaa atgaaggtta tggtaagttg 2339281 ttaatcgaag gccgaatgtt tcattgcagc gaatcaagtg cctaatgtac gcgcgagtgt 2339341 agtttttaca tgtatagcaa tcacactctt catcaatcgg acggaagtct ctttcaaatt 2339401 tcgcattttt catattgagt cgtccttcag cagtaaacac tgtgccgttt cttgcaatcc 2339461 gtgtaggcag cacacagtca aacatatcga ccccgcggat cgctccgtcg atcagtgcgt 2339521 ccggagaacc tactcccatc agatatctcg gtttatcctt cggcaagagc ggtgttgtga 2339581 attcgagtac acggttcatg acatccttcg gttcacctac agacaatccg cctatagcat 2339641 atcccggaaa atcaagcgaa atcaagtcct tcgcactttg tgtccgcaga tcttcatatt 2339701 ctccgccttg tacaatacca aacagccctt gttcatcctg acgattgtgg gcattcaggc 2339761 agcgttccgc ccagcggctt gtccgttcaa ctgacctctt catgtagtcg tactccgccg 2339821 ggtatggcgg gcattcgtca aacgccatca taatatcaga gccgagtgcg ttttggatct 2339881 ccatcgcttt ttccggagat aaaaacagct tgtctccatt tagatgattg cggaaatgga 2339941 caccctcttc ctctatatta cgaaacttgc ttaaagaaaa gacctgaaaa ccgcctgaat 2340001 ctgttaaaat tgcgcggtcc cagttcataa atttatggag cccgcccgct tctttgacaa 2340061 tgtcttggcc cggacgaagc catagatgat aagtgttgct caaaatgatg cctgcatcca 2340121 ttgctttcag ctcttcaggc gacattgttt tgactgtcgc cagtgtgccg accggcataa 2340181 aaaccggcgt ttcgaaggag ccgtgaggcg tatgcacttt gcccagccgc gctcctgttt 2340241 gtttgcattc ttttataaat tcatagcgta ttggttgttc agccactttt gatgaggcct 2340301 cctgttctca aattatataa tcagcatcgc gtctccgaag ctgaagaaac ggtattcctc 2340361 ttccactgca tggttatagg cacgcagaat gttttctctt ccagcaagcg cgctgaccag 2340421 cataatcaat gacgatttcg gcaaatggaa gtttgtaatc attccgtcaa tggctttaaa 2340481 ttcatagccc ggataaataa aaatagatgt ccagccgctt gatgctttaa attgcccgtc 2340541 atgttctccg gcaatcgtct caagcgtgcg tgtcgaggtc gtgccgacag aaatgatccg 2340601 accgccattt tctcttactt tgtttaaggc tgcagccgtt tcttctgaca tttgataaaa 2340661 ctctgcatgc atattatgct cttccacttc atcggcactc acagggcgaa acgttccaag 2340721 gcctacgtgc agtgtgatga actcaatttg cacgcctttg tctttcagct gctgtaagat 2340781 ttcttccgtg aagtgaaggc cagctgtagg cgcagcagca gagccaattt cttttgaata 2340841 cactgtctgg tagcgctctt tgtcatcaag ctgttctttg atatatggag ggagcggcat 2340901 ctctccaagg gattcaagca cctcgtagaa aataccgtca tattgaaatt ccatctttct 2340961 gccgccgtgc tcaagctctt ccgtgcagat tgccttcaat cttccgtctc caaatgtgac 2341021 aacagttcct tttttcaccc gtttcgccgg tttggcaagt gtttcccatt tatcaccggt 2341081 ttcctgtttc aacaaaagaa gttccacttt cgcgccggta tcctcttttg tgccgaataa 2341141 ccgcgcaggc agtacccggg tattgttcag gactagacaa tcgccttcgt taaagaagct 2341201 gataatgtgt ttaaacgagc tgtcagtaag ctctcctgta tgtttatcga gcaccatcag 2341261 ccttgaagca tcacgctgct ccaacggtac ttgtgcaatt aaacgttctg gtagttcaaa 2341321 atcaaataaa tcgactttca tgatgatttc acctttattc tagtcttttg ttatttcatt 2341381 ctgccaaaaa gattaagcaa aattgataat accacactta taataataca agtgacaacc 2341441 gggaagaaaa acgtaacatt tccttttttt acaaaaatat ctcccggcat cttgccgaca 2341501 aaatgcaaaa ctgctccgat aataagcaaa acagcaccaa gaatcataat gatcttagga 2341561 aattcagtca tatcggggag cctccatttg gaaatgatga taaacggccg gtgtcacgat 2341621 ccttccacgc ggcgttcttt gtataaatcc aatttgcagc agatatggtt catatacgtc 2341681 ttcaatcgta tgcgattcct cgccgatggt agctgaaatc gtatcaaggc ctactgggcc 2341741 gccgttgaat ttttcgatca tgcccatcag cagcttatga tcaatatgat ccaaaccgag 2341801 gcggtcaacc tgaagccgct ccagcgcatt ctgagaaatg tcttccgtaa tcctgctgtc 2341861 acccagcact tgggcgaaat cgcgcaccct tctcagcagg cggttcgcca cgcggggcgt 2341921 ccctctcgat cttcttgcaa tttcaagagc cgacggttta tcaatctcaa cctcgaatac 2341981 atcagcggtt cttgtgacaa tatccgccag ttcttcttgt gtatagtact caaggcgaga 2342041 cattacgccg aatctgtctc ttaaaggagc cgtcaaaagc cccaccctcg tcgtggctcc 2342101 caccagcgta aaaggcggaa ggtcgaggcg aaccgagcgg gcagatgggc ctttgccaat 2342161 cacaatgtcc aggcaaaagt cttccattgc aggataaagc acctcttcga tcgatctgtg 2342221 cagcctatgt atttcatcaa taaataatac atctcccggt tccagcgccg ttaatatagc 2342281 agccaaatca ccaggccttt caatcgcagg ccctgatgtc gtccgcaatt ccactcccat 2342341 ttcattagca acaatcgaag caagcgttgt ttttccgagt ccgggcggcc cgtacagaag 2342401 aacatgatcc agcgtctcct gtctcatttt cgccgcatct ataaacacgc gcaaattttc 2342461 ttttacctta tgctgcccga tatactgtgc cagattttgc ggcctcaggc tttgctctat 2342521 cactgattca tggttgtctg cttcacttga gacgagccgt tcatccatga acatcacctt 2342581 actttaatag tttttgtaat gcttttttca catattggtc tgttgtcagc ccaatttctt 2342641 ctttaaggtg aggaagcacc tttttgattt ctttttcagc atatccgaga accctgaggg 2342701 cttcaagtgc ttcttcaaga gccgtttccg ctgtttgctt ttcaagcctt tcttcatgat 2342761 taaacagatt ttcaatcatt tcaggcacaa catctgccag ctttcctttt aaatctagaa 2342821 taatctggcg tgcggttttc tttcctactc caggaaactt gaccaaaaaa gcttcatctt 2342881 cattttcaat tgcttggatg accgctccgg gatcacccga gcccaagatg gcaagtgctc 2342941 ctttcgggcc aattccggtc acgtttaaca gctttgtaaa gagcgccttc tcctctcttg 2343001 ttgaaaaacc ataaagcgaa aaagcatcct ctctgatatg atggtatgta aaaatcgttt 2343061 cttggcttct ctccttatat ataaacggat tcggcgtgaa aatctgatag ccgatgccgc 2343121 cgttctctat gacaatatat tggggagata cataatcaat cgtcccttta acaaattcaa 2343181 tcacgcaaat tcacctcttt gactgttctt cattgtacca taaaaacagc caaagtctta 2343241 tagaaaagtt aacatatgtt cgcttctctc tcattctttc acgaaaaaaa agacatgaat 2343301 acatgtcttc aatcagcgga cgctacccgc tgtatgtctt catatgttcg atgacatcct 2343361 caaactccgc ttttgtccga aatggaatgc ctttcagcag atttttttgc atatggcttt 2343421 ccagcctttc taaatcaatt tgaaaaaaag actgaattgg ttcggaagct ggctcaggcc 2343481 gcccatgaaa agtggaaatc actccattat ccgatacacc gatatacccg ttgaccttgc 2343541 tgagcggaga aatatcgtcc atttgcttcc ggaagagcac atatcccttt ttttgttcca 2343601 ctagcgtcca tccggcataa gctgcccaaa aatcatccat agaaaacact ttttcatgct 2343661 tatgctcaat gctgacatcg ccgtccaaat acaccttttc aagctgcaca tgcacctgca 2343721 gcggctcata gtgctccact tccgcgccaa gtgcgcggga aggagctcct attaaaaata 2343781 ctgccgctga gcaaagaatg cccagcaaaa gatacgccgt gctgaatcgt ttcaccctct 2343841 acacctcttt gcacacgttt atgattagtt tgaccaaaga ggctactgct taaccgtttt 2343901 atcaaaattt gtctgcacat tttccctgac aaaccgttcc tccgtataca catctgtgct 2343961 ttgctcagaa attgtcaaga atcgcgtcag aaaggcactg aaaaaataca atgccgcaaa 2344021 gatccaaatc acgccacctg caccgagcgg cccaatgaaa agactcacga tgcccggcgc 2344081 gataaacgca cataaaccag atcccaaatt caacactgac atggcagcac ctttattatc 2344141 aggtgcaagc gtcggcaaaa gcgcgcttaa tgggacgtac cctgctaaag ccgcgccgta 2344201 gcagcaggcg ataatcatga gcacccaata ctgatgcccg atcagctgag gcgtgtaata 2344261 cagcgccagc gtaaaaatac cgcatccgac accgccaaac cacatgaccg tattgcgcca 2344321 gcctagttta tctccgactg caccgaaaat gatattaaac acaatattca caaaaaacag 2344381 cgtcccccat atttgcagcc attccgaaac cgaatacccg tatcgtgcta aataagtagg 2344441 aagaaagatg gcaaatccaa attgtcctat cgcattaatc gtcttgacca ctccgccgat 2344501 gcctacctta gggttttcaa acataatcgt aaatgccttc gacagttctt tccatttcgg 2344561 ctgatcttgt ttttgtatcg gagtaaattt atctttgtta aaaaataagg caagaattcc 2344621 gcctgccgcc acaaacagta aagcgctcca aagcgtattg atttctccaa aggccggaac 2344681 tgcatagctg gaatagaacg gaccgagcac gttaaggccg cacgtaaaca taaaccaaaa 2344741 ccagccgacg gcttttccaa gaatattttg agaggtgctg tatgacaccc atacgagaaa 2344801 agagtatgca aacagcggat atcccaagcc tctaagagca tagctgccca agagagccgg 2344861 ataatacata tgaggaatcg cccagccgat aaaagcggcc gaaccgagga taaatgcaag 2344921 caatccgaca gtcatcgttt ttctcggccc ccaagtttgg acaaacgttc ctgaaagcca 2344981 agctgagatg gtgacagcaa tgccgtacat ggtaaataac gatgcggatt gctgcatact 2345041 gagaccatga tcaacgagaa aaggagacag ccagccttgt tcgaggccgt ctccaaccat 2345101 aaagatgaca acgccaatat aaccccaaac catgtgagaa ggaattccga ttttgttcaa 2345161 aacatttcct ttagcatgta ctgtattcat tttctccacc gcctacttaa agtatcaatg 2345221 gagtatatac ccaagcttgc tgaattgtaa tcctgttaga ttaaaaagcg attttttcag 2345281 tgtgctcaat gctaacaggc atgccaaaag caagcgattg ctgtgctgct ctggcgatcc 2345341 tcccggcctg taaaccgtca ttgccggtgc agggagtctc ctggtttgtg ccgatcgctt 2345401 ctgcaaaacg gagaatctcc tcctcatatg aatccttata gcgttcaagg aaaaagaaat 2345461 gcggtttatc cttcatcaca aaatcagctg ttgacacctc aaccgttgtc ggcctgctat 2345521 tgtcagccgc tgcagagcct ttcgtcccga aaacctcaac ccgctggtca tatccgtaca 2345581 cagcttggcg gctgttatca atcacagcca tggcaccgtt ttcaaaagtc agtgtaataa 2345641 cagctgtatc aatatcaccc agctccgcaa aagaaggatt caccaaagcc gcccctttgg 2345701 catacacttc cgtcacttcg cttcccataa tatatctggc catatcaaaa tcatggatcg 2345761 acatatccat aaacaatccg cctgacgtac ggacataatc tatattcggg ggttctgggt 2345821 cccgggacgt gatttttaat aaatgaggtg taccgatttc accattttca acaatcgttt 2345881 tgattttctt aaaatgagga tcaaagcggc ggttaaatcc gacttgaagt gttaccccgt 2345941 gtttccggac agccgcaagc gcttcactcg tttcgtccag agagaaacta acgggcttct 2346001 cacaaaatat atgctttttc gcctcggctg cttctttgat catctgtgca tgtacggctg 2346061 taggagagca aataaaaata gcatcaatat caggatcatg taataaatca cgataatcag 2346121 aggttatgta ttcaatctga tgactgtcgg cccagctttt tatacggctc gcctgaatgt 2346181 cagagattgc ttttattttc atgtgaggaa tccggcttat attttgaaca tgaagtttgc 2346241 cgatgcggcc tgcaccgata atccctgtca caatctgttt tgtcatggct tcttccccct 2346301 tgatcattca cgaaagcgct ttatttaaaa ttaatactat cccatttgta agcgcttttc 2346361 aagaatggaa attaaacgtt ctatgtctct tttatcacaa ttcatgctta taagtagcct 2346421 tcttcttcaa gaccagatac actagaatta ggctcttttt cctgaacagt ttatgatttt 2346481 cctataaaca gctgcataaa atagagcaaa gaaggtgaat gaaatgctga caaaagcaga 2346541 ggcactggcc cataccgtca tataccgcaa gaacagcaga tttgataaag tcaaagagaa 2346601 atccgaggaa ttaacactaa tcggcaaggg aagaagcgcc tatgtgtttg ccttaacaga 2346661 aggcggtcga aaaatggcgc tgaaagtatt ttttccggaa tatcaagcga cagcagtcaa 2346721 agaagcagcg atctatgaaa aattagccgg gtccgcattc tatcctgaca tttacgaaac 2346781 tggcgattca tttattctca tggaatatat taaaggtgaa accttttata actgtctgaa 2346841 gaaaggcatt gcaatcagtg atgacatgat tcagcaggtt gaagaagcgc tttctgacgc 2346901 ccgggcagcc ggactgaacc cgtcagatat tcatttgcgg aatctgatat tgacagaaac 2346961 cggggcggtg cgggtgattg atgttgcgag atttgagcag acaaaaacat gcacgcagtg 2347021 ggacgactta aaatccgcat atcatgcact ctacaaaaaa ccgatattcc ccaaaaagat 2347081 tccgggtttt tggctggaga tcatcgcatt tttatataag aaagattggt ttcaaaagca 2347141 tttcgcacag cggaaaagaa aatattctta aatcaaaaag gcagccgcac aagcggctgc 2347201 ctttatcatg tattttttac tttctgacgg cagaaatcag tttcatttgt tcaggcgaca 2347261 gcttaattcg atagcctctc acagttaagt agaccgcttc tgggtccttc tcgccggaat 2347321 gacaatacgt tttttccatt tctgtctccc ctcacccttt attggcttta tttcatctta 2347381 tcattgcttt attgaggtaa ttttaaagaa atgtaaagat tatatgaatc cgatatatag 2347441 taaaatgaga gaaaaaaagg gagagagtca cattaagacc gaaaacacct tgagcttaga 2347501 tgcagccaga ggtgaacttg taaatgaaaa aacacttgtc aagagaacaa tctactggaa 2347561 ttacccggac agccgcccag cagtgacgtg gatcaatcac aatacagtga aaatcggcaa 2347621 tcagacttta catcttgata ctgatgaaac gtatgattgg cgaaaagatg atcattggat 2347681 ccgtgaagaa ccgccgcagg cgtcagtgag gtgatgaaac atgaataaga tgaacggaac 2347741 aaatgatgaa aagcatttca atcattttgt gattgcttta tcctttatat acggtttgac 2347801 tgaactaggc tatttgttgc tgaaggattt tataacaatt gccataagtt tgcctctgta 2347861 gaaaaacgca gcgtagtcga tacgccgcgt tttttctttt tcccttcctc ttcttattga 2347921 taattacagg tcatataatg tgacaaatcg attgtagaaa tagttcgatt agaccaaaat 2347981 cctttttata catgtattcg aatttgaagt gagggggaag cttgatggca gattttgttg 2348041 ctagtttgaa tgcggtctta tggagtacgc ccgtcattta tattttattg ggaattggat 2348101 tcgccttttc aattatgacc cgttttttac aagtccgaca tttaaaagaa atgattgttc 2348161 agatgttcaa aggcaagagc tctgaagccg gcgtttcatc tttccaagcg ttatcgattg 2348221 cgctgtccgg ccgtgtgggc acaggaaaca tcgcgggagt ggcgacagca attgcattcg 2348281 gcggacccgg tgcagtgttc tggatgtggg cgattgcctt tatcggggcg gcgagtgcct 2348341 ttgtagaatc aacgcttgct caaatttaca aagtgaaaca agacggtcaa tatcggggcg 2348401 gccctgctta ttatatagaa aaaggcttag gcattaagtg gtttgccgtc ttatttgccg 2348461 ctgctgccct tattgcaatg gcctttctaa tgccgggcgt acagtccaac tccattgcgg 2348521 ctgggatcca aaatgcattc ggcatctctc ctttcgtcac agggtgcggt ctggttttat 2348581 tattagggtt cattattttt ggcggcgtca aacgaattgc caatgcggcg caaatgattg 2348641 ttccatttat ggccattgga tatatcctgc tgtctttgat tattattgtc atgaatgtgt 2348701 ctgaattgcc tgctgtgatc tcattaatat tcaaaagcgc cttcgcattg gattccgctt 2348761 ttggcggctt gatcggtatg gcgatttcct ggggcgttaa acgtggcatt tactcaaacg 2348821 aagccggcca gggaacaggc ccgcatccgg cagctgctgc agaggtttct catccggtca 2348881 agcagggact ggttcaggca ttttctgttt atattgacac cttgtttgta tgttccgcta 2348941 cagctttcat gatcttgttt accggcatgt acaataccca ggctgcagat ggttccttta 2349001 tcgttcacca gcttaaaggc gtagaagcag gacctggttt cacacaagcg gcaattgaca 2349061 gtgttcttcc cggattcggt gcaggctttg ttgccatcgc tttattcttc ttcgctttta 2349121 caacaattat ggcgtattac tacatcgcag aaacaaatat cgcctattta gcacgaggca 2349181 gagaaagcaa atgggcgatg cttggcttaa aactgattat tttagccgcc acgttctatg 2349241 gtactgtgaa aacagcttca cttgcttggg cattagggga tgcagggctt ggcattatgg 2349301 tatggctgaa cgtcattgcc attgtgctgc ttgccaagcc ggcgctcctt gctttaaagg 2349361 attatgagcg ccaaaagaag cagggcttag acccgatctt tgatccaaaa gcgctgggta 2349421 tcaaaaacgc tgatttctgg gagaaagaat acactcatga aagtgaacgt gtctcctgaa 2349481 catactaaaa ccggcccgat atgacctcgt gccggttttt tatgaacgat agtttgtata 2349541 cacttcttga acatcatcgt catcttcaag gacgtctatt aatgtttcca gcttctcaac 2349601 agcctgatca tcggcttctg cataggtatt gggaagcatg gtcacctccg ccgaagaaat 2349661 tagatatttc gattcgaggg ctgttttcac ctcttcaaaa tgctcaggct ctgtgaaaac 2349721 ctcatatagg tcttcttcaa ttcgcagctc ttctcctcct gcttcaagca catcaagcat 2349781 gagctcatct tcttctattt gccgttcagt acggtctatc gtaatgaacc cctttcgttc 2349841 aaataaaaag gctacacatc cgctttctcc cagacttccg ccatttttat taaaggctgt 2349901 ccgcacattt gacgccgttc ggtttttatt atctgttacg cattcaacca tgacggcaat 2349961 ccctgaaggg ccgtagcctt cataggtgat ttcttcatag ctgcttccgt cttggcctcc 2350021 cgcagctttt ttaatggccc gatctatatt ttcattcggc atattggcgc cttttgcttt 2350081 ttcgatgaca agacgcaatg ctgaatttgc ttctggatcc gctccgcctt ctttcgctgc 2350141 cacatagatt tcttttgcca gcttcataaa tattttcccg cgctttgcat cctgtgcatt 2350201 ttttcttttt tgaatgtttt tccacttgga atggcctgcc atgttttcac cttcttttac 2350261 attttctatg tacactttaa tgggaaatgt tcgctgatgc aaagaaaaag gctgccgaat 2350321 atcacttccg gcagcccttc cttcctagcg gttgttcatt ttatgaagtt ttctgaacag 2350381 ccctttatct gttgatactt ggacgtcacg gccatttgca tagttgcgcg ctgcttttac 2350441 aacattatct ctgtcagact ttgtgaactc tctgtggctt ttgactgcga taactactcg 2350501 gtcatccgat accataactt gtgtgtcatt gacgtttttc acttgtttca cacggttggc 2350561 aatttttgca gccagtcttc tgttttcttg gttgtcatac ccgttgttcg ctgcattccg 2350621 attcatgttt cggttattcg tgttgttata tgttccgtca gttgccaaag gaacacgatc 2350681 gtcagcagta acacggtcac ggttatttac attcgtggtg tttcggttac cgtcgttctg 2350741 atcctccatt aattcagaaa caggaccatc gtggtcgatt ccgtctccct gtctatcggc 2350801 gtcattttca tttgtataat atccgattgg acgggtattg ccgttattgc gcgtatcatt 2350861 catagcatta tcgtttgctc cgcatgctgt taagccggct gtcattagaa tcaggctagc 2350921 gatcgtcatt tttttaccca atggaaaaac cccccgtgga cgaattgagc atgtttgctc 2350981 gcttttatca tgtgcgtatg gggggcatgt taagcgtgtc agttctctcc atttggcagt 2351041 gatctgcttg aaaacaaaaa aaggaacgat ttacatcgtt ccgaacgatc actcattttc 2351101 ttcttccgga cggccaaaca tttggtttac agaaggctgg ttcgtcattg gcatagaaac 2351161 tcctgccgaa tatgggtttg gatttgggtt agctgtgcca tatggcatat tagggcttcc 2351221 ataagctccc attcccgaat ggccaggtgc agagaaatat ggctgatgat caccgtcaca 2351281 gccgcagtcg tcatgatctt tgtatggcat gtaaccatga gccgcagcag gctggtatgc 2351341 tcccattact tggggagtgc cgtaataagg gccatacggc atatgtccat acggagatcc 2351401 ataagccgga gatgcgtatt gcggcgcacc gtatgaaccg taatgtccgt gatggctgtt 2351461 ttcatgatgc tggttttcat aacccgggtc atactgaggc gatacaaagc ctggctggta 2351521 tccatgcatc ggatgcattg gataagcttg tgccggatag tacggatagc ataatcctga 2351581 tcctggaaga attggcgaaa caggcaccgg acacggtacg aaatgagccg gataatgata 2351641 ataaggctga acagccggca tcggcatatt cggaactgtg tgatgaacgt tttcctcttc 2351701 tataccgcct acctctggcg cctttggcat attaggcata ttcggataat ttgcattttc 2351761 catattactc atagcctcct gttgtggaaa ttggtcttgc atatgataca tatgatccat 2351821 atttccgtca tgatgttttt tcggctcctc cggtttagga ggcgaccaag gctggaaaag 2351881 ctgtttcata tcataataat cgttcacatc agcttcaggg tacacatttt cctgcaaatt 2351941 aggcatcggc gggacatacg gcatggactt cttttctttc ggctttgtgt cttctacatc 2352001 gacaacggat ttaggcttct ctttcgcata tggatgttct tgcttcacac tcccggccgc 2352061 aggacttttg cccgcttttg gctcttttct gaccgggact ccttctgacg gcacttttat 2352121 tttcattcca ggcatgatta agtctggatt gctaagctgt gtattgagtt ttttcacttc 2352181 ctcaacatcg actccgtact tttcagctat tttccagagc gaatcgcctt tttgaacgat 2352241 atggattttc aacgttttcc cctcctatgc aaaacgtgaa cagttcagct gtgattacaa 2352301 tatgtttctt cacaacatat gcctgaacaa aagaagttat gagtaaagga agggaaaata 2352361 tttctgatct acgtgatcga aagcattcga ttcagggcaa ggagtgcatc ttcctgaatg 2352421 gcttttggca ccttgatgac gcctgaaggt tctccttttt caatttgttc cagcgaccac 2352481 aacaaatgcg gcaaatcaat tcggttcatt gtcaggcaag ggcacatgtc agggttgagt 2352541 gattcgattt gtttatctgg atgctcgtga atgatccgct gaacaagatt catttctgtc 2352601 ccgattgccc acttgcttcc cgccggagcc tggttgattg tgtcgataat atatttcgtt 2352661 gatccgttat catcgcttag tgtcacgact tcgtgtgaac attccgggtg cacaatgatc 2352721 tgaatgtcgg ggtctcgctc tctcatatca tggatatttt tagtggtgaa tttctcgtga 2352781 acagagcaat gccctttcca caaaatcact ttcacattcg tatgcccgga ttcagctact 2352841 aattcatctt tcatcggatc ccacacagcc atatcttcaa gcgcaatgcc cagatcataa 2352901 gccgtatttc tccctaaatg ctgatcaggc aaaaataaaa ttcttttttt ctgtgtaaac 2352961 gcccattcaa gcactttttt cgcattcgaa gaagttacag ttgctccgcc atgctttccg 2353021 acgaatgcct tgatctccgc agtggagttc acataagtta aaggtatgat cgtatctcca 2353081 aatatatgct gaagcttctt ccatgcccta ttggtctgct gcatgtcagc catgtcagcc 2353141 atagaacatc cagctctcat atctggcagg acgaccgttt gctgctcgct tgtcagcata 2353201 tcggcggttt ctgccataaa gtgaacgccg caaaatacga tataatccgc ttctttgttt 2353261 ttttccgcta cttgggccaa ttgcagggag tcgcctgttt ggtcagcaaa ttgtatcact 2353321 tcatcctttt gataatgatg gcctggtata aagagcctgc tgccgaactt tttcttaatg 2353381 gcggcaacgc gcgtttccat atcctttctc gatagttctt tataactttc gggcatcata 2353441 tcattcgatt gtttgatcac atcaagaatt gacataacag cattcctcca cagattcatt 2353501 tgataacgta acatccatgc tgatatctaa acttttgacg gaatgagtca gaaatcctaa 2353561 tgaaatataa ttcacacccg tccctttaaa agcaggcaaa gattctaacg taatcccgcc 2353621 agaggcttca gtttttatat tagccggtgt gagctttgca aaatgacgga ccgtatcagg 2353681 cggacagttg tcaaacataa taacatccgc tccagctgca attgcttccc gcagctgttc 2353741 ctccgtttca atttccacct cgatatttac catgtgccct gcggcctgac gggctttttt 2353801 gcacgcctct aaaatagagc cgcatgctgc gatatgatta tctttaatca tgatgccgtc 2353861 atacaaaccg aatcgatgat tatacccgcc gccggctctg acagcatatt tctccagcat 2353921 tctgagcccc ggtgttgttt ttctcgtgtc acaaatttta atctgttcat catccagaca 2353981 ccgaacagcc tctcttgtca ttgtcgcaat tcctgacagc ctctgaataa gatttaatac 2354041 gacccgctct cctgaaagga gcgcagctgc gggaccgtgt aactcggcaa tcacttcacc 2354101 tttatgcaac atgtccccat cttttttgtg taaaatgctt tgaacatttt cgtccaataa 2354161 cgaaaagcct tcttttatga tcgctgctcc tgcaaaaata ccctctgact ttgcaacaat 2354221 ctccgcttca cagctctgtt ctccaaaaat agactgcgat gtaagatccc ctgtcccaat 2354281 atcctcaaga aaaaagtgat tcagtaattt tttcagctgt aaatgattca ttgttccaaa 2354341 tcccctcgtt ttttctgatc ttcgttcctt tttttgtatg gacaatttgt cttccttgcc 2354401 agctcacctc agcatgagga aaatcggtgc ggaagtgagc ccctctgctt tcctcccgca 2354461 aaagcgcaga aaacgtcatc agctttgcag tttgccatag atgagaaagt tccatctgcc 2354521 gaattgtgat atccttcaca tttacttcct gaaaaggcag cgtatgaagc cagatgctaa 2354581 gctcaatcaa actgctttgt tcccgcagaa tagacatgtg gcttgtcatt ttgctttgca 2354641 gttcatgccc ctctatatcc ggcacctcgt agaagacact ggtttctagc cctgattgat 2354701 attgcctgtt ataaaccggt ttttggataa tatgctctgc tgcccttttt ccaaatacca 2354761 gcgcttccaa taaagaattg cttgcaagcc ggtttgctcc atgtaaaccg gagcatgctg 2354821 tctcgccaat cgcataaagc cccggcactg tcgtttctcc ccagcgatta actgaaacac 2354881 ctcccattaa gaaatgcatt cccggagcaa caggaatttt tccgctgtgg atatcaatcc 2354941 ctgctttttc acaaatagcg gtgatggtag ggaaacgcgt ttcaaaatca gaaatcgcac 2355001 tgaagtctat ataaacgcga tttccttttg ccatttcttc gtgaataacc cgtgagacaa 2355061 tatctcttgg agccaggtca cctaaaggat gccgttcagc cataatcctg cggccgtttt 2355121 cgtctactaa acatccgcct tcccctctga cagcttctga aacaagcccg taggaaacac 2355181 catttttcac aagcagtgtc gggtgaaact gagtaaactc caaatccgtt aattccgccc 2355241 cggcccggta agccagagaa agaccgtcac ctgtgacagt gagatcattc gtatggtgaa 2355301 gaaacaggtt tccacagccg ccggcagcca gcacaacttc gtctgcgtgc cttaccttga 2355361 gccgcccttt gctgtctttt gtcatgacgc cgatacatcg tccgtcctct ataagcaaat 2355421 ctgctgccgt ttcattctcg attaacttga ttttgctgtt gatccgtttg agcaaataat 2355481 cgataagcag cctgcctgtt gcgtctccgc ctgcatgaaa tatgcggttg tatgagtggg 2355541 ccccttctct tccaagacaa acaccgcctc gttcattgcg gtcgaatgga aatccacgct 2355601 ccaataggct ttgaaccatc atttttccat catgtaatac gtctgctaca atagctagat 2355661 tattatggcc gcaccctgcg tataacgtat cctccagatg ggcttcaatc gagtcatctt 2355721 ttgcataggc cgcagcaatc ccgccttgtg catagacaga attgctgttt ttgacgcttt 2355781 tttttgtgat aacagtcact tcgtatgagg gcgggaaagc tgcagctaag gaaagtgccg 2355841 ccgcccctga accgatgact gcaatcgtct ttttagacat atgccatcct cctgttgttt 2355901 acacctgtct tgacacctat atttacacaa ggataaaata aactcaagag ttttttatgg 2355961 agaacggatg gaggaagacc ggatgattta tttagattat gcagcgacaa cgcctatttg 2356021 tgaggaagcc cttactgtat atcagaagct tagtatggat atgtacggaa atgccagcag 2356081 cctgcatgat gcaggaggaa aagcaaagca catactggag tactgccgtg aaaaaatcgc 2356141 caacatcatt ggcggagaag caagcggcat ctattttaca agcggcggca ctgaatccaa 2356201 ttttctggcc attcaatcat tgttaaacgg cctgccaaaa acgaaaagac attttattac 2356261 gactgccatg gagcatcagt ccattcataa ttgcgctgct tttttggaac agcagggata 2356321 tgatgtaaca gtcattgaac cgaatgaata cgggcttatt accgaggaaa tattactaac 2356381 ccatatccgg ccggaaacag gccttgtatc tattcagcat gcaaattctg aaaccgggat 2356441 cattcagccc attcaacacc tgtcttcata cctgcacaat aaggggattc ttcttcattg 2356501 cgacgctgtt caaacgtttg gaaagatccc gatcaataca aaaaatctgg gagtagatgc 2356561 actctcaatg tccagccata aaatccacgg tcctaaagga gtaggggcgg tctatatccg 2356621 gccggatgtc ccttggaaac ccgtttatcc tctgactact cacgaatacg gattcagagc 2356681 cggcaccgta aatgttcccg ggatcggtgc cttcactgcc gctgcagaat tgatcgtaag 2356741 cgaaatggaa aaacagatat cccgcaatga ggcattaaga acatactttc tagaccaaat 2356801 ccgtattcgg tctctccctg taacccttgc agcagacact tcgaaagcag aatgtcttcc 2356861 gcatattata gggtgttttt ttcactcatt tgaaggacaa tatgttatgt tagaatgtaa 2356921 tcggagtaat atttgcattt caaccggcag cgcttgttct gcaggttacc acggtccgtc 2356981 tgaaacaatg aaagcattaa gaaaaaccga acaagaagct ctgcaattta tccgcatctc 2357041 ttttggcagg catacaacag ctgaacagct ggaacagtta ttacatacgt ttacagtgct 2357101 ttgggaacaa aagaaaggag aatttgatat tgaccgaaga attaaagcta atgggcgcca 2357161 acaggcgtga ccagcttctt ctgtggctga aggaatctaa atcaccgctg acaggaggag 2357221 aactcgcaaa aaaagcgaac gtctcaagac aggttattgt acaggatata tcgctcttga 2357281 aagcgaaaaa tgtaccgatt atcgccacaa gccaaggata tgtatacatg gatgcagccg 2357341 ctcagcagca ccagcaggca gaaagaatca tagcatgtct gcacggtcct gaacggacag 2357401 aagaggaact gcagctcatc gtcgacgaag gcgttacagt aaaagacgta aaaatcgagc 2357461 atcccgtata cggagattta actgcagcca tccaagtagg cacccggaaa gaagttagcc 2357521 atttcatcaa aaaaatcaat tctacgaatg ctgcctactt atcacagctg accgacggcg 2357581 tgcacctgca tacactgaca gcacctgatg aacatcgcat cgatcaagcc tgccaagccc 2357641 tcgaagaagc cggcatttta attaaagact aaaaaaagcc ctctagtggg ctttttttat 2357701 aattggtaag actggtatgc acccagaagc ctcactttgc agccgagtgc ttcaagctcc 2357761 tgcatggccc ctggaatcaa tacatcatca aacgctttct caatatcaat aataaagaaa 2357821 taatggccta atccggtttt agtcggacgt gactcaattt ttgacaggtt taaatttctc 2357881 caagaaaatg cagacagcac tctatgcagc gccccggact gatcatcctg cggcagcatg 2357941 accattaagg tcgttttggg cctagagctc aattttgaat tcacttcaaa agatatgttt 2358001 tcatcgggag acaggataac aaatcttgta tgattgtccc tataatcctg tatatcccgt 2358061 ttcacgattt ttaattcgta tgtagaagct gccatatcat tggcaatgac cccgatattc 2358121 agctcgggat ggtcactgac aaactttgct gccgccccgg tagaattggc gtattcatat 2358181 ggaacggaag gaaaatgtcg atgaagaaat ttatggcatt gcgcaatcgc gtgtgaatgt 2358241 gagtaaattt tgtcgagctc tttccatgca ttctctcttg agggatggac gagcaagtgc 2358301 tggtgaatcg gcaacgtcat ttcacccacg attggcaaag gctgttcatg tattaaatag 2358361 tctattgtta gattaacaga tccttctaaa gcattttcca aaggaacaaa agcaaaatca 2358421 acttcgcctg caacggctgc atctatacac tccggaatgg tgcggtaagc aacatgttcg 2358481 gcgccgtttt gaaaacaaga actgactgct agatgtgtaa atgtagctgc tggacctaaa 2358541 taaccgactt tcatgacgat tttctctccc ttatgcacct gaacctaata tttcaacctt 2358601 ttctacaaaa tcaaacttcc tgagcttatt cattaatgta tgaatgtctt cttccattgc 2358661 cgacgtactg atagacagtg tcacatttgc tctgccttga agcggaatgg tctggtgaat 2358721 ggaaagaacg ttgcttccag aatcagctac cgcctgaaga agctgagata acgcacctga 2358781 cctatcctcc aaatgaaaga aaagtgtgat aatttgttct tttaccatgg tgtagaatgg 2358841 aaaaacagca tccctgtatt tataaaacgc acttctactt aaatcgacct tttgaacggc 2358901 atctgctact gaatctgctt tttttcgatc aagcagcttt ttgacttcta atgtttttct 2358961 cattgcatcg ggcaatacat cttcacggac aagataaaat gtctcctctt tcatttgcat 2359021 ccccccttta aaatagagag cctggcacca ggctctcttt tcagccaaca ttgattaatc 2359081 aataaattca aattcaaatt ccagaagcct gattatatct ccatccttgg ctccgcgttc 2359141 tctgagtgct tcatcaacac ccattccgcg catctgtctt gcaaaccgtt taaccgattc 2359201 atcacgtgag aaatcagtca tcttgaataa ccgctcaagg ctgtctcctg aaagcacaaa 2359261 tacaccgtct ggatcgcgtg taatgttaaa tggcacttct tcattttcca tcgtgtacat 2359321 gacacggttt tgtgtaagct cttcctcgtc atacagcggg aattccggtg tgttctcaag 2359381 ctgattggca acctcaaaca gaagctcacg cagaccttct cttgtcaccg cactgatcgg 2359441 gaataccgga taatcatccg tcagcttttc tttaaaggct tcgagatttt ccgcagcctc 2359501 cggcatgtcc attttatttg caacgataat ttgcggacgc tcagtgagac gcagattgta 2359561 ctcgctcagc tcctggttaa tcgtaagata atcatcatat ggatcacggc cttctaagcc 2359621 tgacatgtca atgacatgaa caataaccct cgtccgttca atatggcgca aaaactggtg 2359681 gcccagtccg acgccttggt gtgcgccttc aatcagccct ggcaaatcag ccatgacaaa 2359741 gctgcgtccg tcatccgttt caaccatgcc gagattcggg acaagcgttg taaagtgata 2359801 gtccgcaatt ttcggttttg cagatgagac aacagacagc aaagtagatt ttcccacact 2359861 cgggaacccg acaagtccga catctgcaag cacttttaat tcaagaacaa tgtagcgttc 2359921 ttttcccggc tcgccgtttt ctgaaagctg aggcgcggga ttagccggtg tagcaaagcg 2359981 gctatttcct cttccgcctc ttccgcctct tgcaatgaca gcccgctgtc cgtgctctgt 2360041 taaatcagcg atgacctgtt ttgtatcatc gtctgtcaca acggtgcccg gcggaacttt 2360101 aatgaccata tcatcagcat ttcgcccgtg ctggtttttg gacatgccat gctcgccgcg 2360161 aatcgcttta aagtgttttt tgtatctaaa atccatcagg gtgcggagac cttcatctac 2360221 ttcaaaaacg acgtctcctc cctttcctcc gtcaccgccg gcagggccgc ctttcggcac 2360281 atatttttca cggcgaaacg caaccatacc gttgccgccg tcgccgcctt ttacatatac 2360341 tttgacctga tctacaaaca taatgtcctc cgttctaaac cgttaaaaac tccgctagtc 2360401 caacccaatt tcaatcagac attcgtgact cgtgatttca aaacgcatga tatcaacgtc 2360461 ctcatatcca ttctgccgaa tatcatcaaa agcagatgga tcggcaaagg cgccgtgaaa 2360521 atcaaggtac agaatcagct gtctgtcagg atgatccgtt tgaagcgaaa ccgttaaatg 2360581 attttcactc tctctgctga ctgcttgatc aaacagatga aacagctttc tcatcagttt 2360641 cgccagcttt tgatcataag ccgacaaatc cttaatttct ccgagaactt catattcaag 2360701 cgtcatataa tgggttttcc aattaaacgt aagaaaatca aacgccaaat gcggtgtttt 2360761 caggtttgag agctttgatt cgtgctttgc gtctataacc atttcttcaa tcatttcaaa 2360821 gacacggtca tacttctgta agcttaagtt tcctttaatc agctgcagct tattcatcca 2360881 atcatgccgg gaatggccaa gcagatgaat cagttcgttt gttaatgccg tgtcgcttat 2360941 attttcttct tgattttttg aaacatcctt cattttcgca ctcccaatca tttaatttct 2361001 tatttaggag tctgtataag tgtgtattat gaattataac agagaaggct ttgttagaaa 2361061 aacaattgtt tttcccagaa atatcatgtt ccttttttct ggctttggtt gatttgcagc 2361121 caggcagaac attttatgta ttactgcttg gggaacatat ccagtgggtt tgagatgttt 2361181 attctcattc ttggcggggt ctgctcgcac atactctgca tttcattcta ggtgtttact 2361241 ccgcatattg caaaaaaaac tccagtcatc atcgaccgga gttttttgaa tcattattga 2361301 gctacaggat atacgctcac ttttttgcgg tcacggccga aacgttcgaa tttaacagtt 2361361 ccgtcgattt tcgcaaatag agtgtcatct ccgccgcggc ccacgttttc acctgggtaa 2361421 atttttgttc cgcgttgacg gtaaaggata gaaccgcctg ttacgaattg accgtcagca 2361481 cgtttagcac ctaaacgttt agcctcagag tcacgtccgt tctttgtaga acctactcct 2361541 tttttagaag cgaaaaactg aagatctaat ctaagcatgt agctcacctc ctatattatg 2361601 tttgtggtca cacgcaagtt gtctttgtaa tcccgttcga ttgtctccag cgaaacaatc 2361661 atgccttcaa tcagcagctg agctttttgg cgtgcctctg gatcaagaga ttcagggaat 2361721 tcaaaataaa aataaccccc gtcctctcct atatcaagaa gcggctcgaa gcccgcgagc 2361781 acaatgaccg cgttaacggc cccaaacaca acggctgtca ctccggcaca aacaagatct 2361841 tgtccatgtt cagcaaaatt cgcatggccc gtcatttcaa aagacaatat gcctttatca 2361901 tgagaccttc tgattgttgc ctgaatcatg cttacgcgtt gattttttcg atcgtcactt 2361961 tagtgtaagg ctgacgatga ccttgttttt tatgaacgtt tttctttggt ttgtatctga 2362021 aaacagtgat ttttttcgcg cggccttgtt tttcaacttt agccgttact gttgcgcctt 2362081 caactgtagg gttgccgact ttcacgttgt ctccgccaac aaacaaaacg tcttcaaaag 2362141 taactgtttc acctgcttca gcagcaagtt tttcgatgta aacagtttgg ccttcttcaa 2362201 ctttgatttg tttaccgcct gttttaatga ttgcgtacat tctctgcacc tcctattaga 2362261 ctaagactcg ccagatacca gggggctgta aaagctctta acacctgtac tgagcggttg 2362321 tagcaatggt gctacatcca taacattaaa aaatatacca aaatacaagg cgtttgtcaa 2362381 tcagttttag tagggcagaa gcagttcctc catggaagaa ttcgtccgct tatcggcaaa 2362441 gtaagcgtgc agcacttcat tctcgtcaag ctggctgagc ttttggcctg atttttctat 2362501 aataatcgga tgcttacagc cacgtttgaa ctcggccatc acatgataga ctttatcctc 2362561 cgcctttact gtcagcggca gaagtttctc aagctccctg ttttttccgt aatacctttc 2362621 gaggagaaat ctcacatgga tatagtgcct ttgccgatat tcctcaaaca aggaaacagc 2362681 cagaaagaca aacaaaaccc atgcgctgat ttgcagagga atcacgaata aaacccagca 2362741 cccgagcagc aggcagaagc agagcgacgt ttttagatta agccggtgag ccttttgaaa 2362801 aggcagctgt ttggaaaaca acaaaaataa cagttttcct ccatccagcg gccagatcgg 2362861 cagtaaattg acaaataaga tagaaagatt ataaaaggtg aagagttcaa aggtatgctg 2362921 atgaatcact gagacttctg caagcatcca ggcggcaaac tgaagccaga tgtgctgaag 2362981 aggtccggca ataatgaccg caaactcttc ctttaacggc cgattcccgt gctcttccac 2363041 ttcgaccgtt ccgccaaacg gcagcaaaaa aacacgcttg attctccaag aaaaaaacac 2363101 agccagagca gcatgcccca gctcatgaat caatacaatc aggagcagac ataataatgc 2363161 tttcatatgg cctgtgagca agcccagcgc cgcaataatc caaagaaaag gatgcacatg 2363221 gatctttaag ataaggtcga gccatttatt caaatgaaat cacctgaatc ggatcaataa 2363281 atttatcgcc gtctttcatg gcaaaataat agaccccttt attatgatca tcaagcttaa 2363341 tcgaaccgag ctttttgcct ttatccacaa aatcatataa agcaacatcc acatctttga 2363401 gctcgccata gatactatag gtgttgtcag catgctgcac cttaaccgtc agtcccgttt 2363461 ggctgtcttt gctgacttca accacatagc cttcttttac gctatcaatc ttatcactgc 2363521 ttgtttcgac tttaattcct tccccattgt cctgaaaatc ctgctgtact ttcccggatg 2363581 caggcgcgat cagatctttg cctacttcaa tctgctgttc cttatttttg tgttcaggag 2363641 ccaggaaagc aagcggattt ccgaatttgg tttcgaacca atggcttgct gaagcaaatt 2363701 gaaattcagt ttcaaaggtt ttggctacgg cgggtttaat ctgactgacg ggtccaatgt 2363761 ttgttttata ggctatagct gaaacgagaa caaggcaggc cgacagaaga catttcagga 2363821 taattgaatc tgttttcacc aatgggtgtt ttccgttgaa tgttggcatg ttatcttcgt 2363881 agaccggaag tgttccatgc ttttcctgat ccgttaccat cacccaggac gggggtttct 2363941 gcttttcaga aactgtctga gtagagaaac gttttgagcc ggaaagctgc tttcttcttt 2364001 tctctaatcg ttttctgatt tcatctgctc tgtgactcat tgccatcatc ctttgcattc 2364061 gttgggtttg tacatcatat gtcttgtcca tggcaaatat tcggtttagt caagaacaaa 2364121 gcaggcaaaa acaaaaaaaa cctgacacag catatgcttt gtcagattct tctctttgat 2364181 tctatcacat taagatctta ctccgaaaaa tgacttaatc ttagccatca ttcctttgtt 2364241 ttgctcttca agcacctgta aaggaacaga ttcacctaag atgcggcggg caatattgcg 2364301 atatgcaatg gaagcgcggt ttttagggtc catcgcaatc ggttcgccat gattggaagc 2364361 tttaatgact tcatcatcat cagccacgat tccgagcaaa tcgatcgaca gatgctgtac 2364421 gatttcgtcg atatccatcg tgtcaccgtt tttcatcagg tgatttctga ttctgttaac 2364481 aacgagccgc ggcggttcaa tattttcctc ttgctccagc agtcctataa tacggtcagc 2364541 atcacgaaca gctgagattt caggcgtagt gaccacaatc gctttatcag ctccggaaac 2364601 ggcatttttg tacccttgct cgattccggc aggacagtct atgatgacat agtcaaattc 2364661 ctgtttgagc tcttggacca tgtttttaat ttgttcagga gcaacagctg tcttatcgct 2364721 cgtttgagca gcgggcatta aatagagcag atcatcgaaa cgtttgtctt ttacgagcgc 2364781 ctgatgcatt ttgcatctgc cctctacaac gtctaccaga tcgtaaataa ttctattttc 2364841 aagacccatt acaacatcaa ggttgcgcag tcctatatca gtatctacta agcatacgcg 2364901 cttccctaaa atggctaagg cggtaccgag gttcgcagat gttgttgtct tacctactcc 2364961 gccttttccc gaagttatta cgatagcctc acccaattca cattcctccc tcaagccttg 2365021 ttagatcagg tcttaaatga gccaaatgtt gaaggcgttc aatgaccata tttccgtctg 2365081 tatctaaata agcacattcc atttcgttcc ctttttgaat gtggtctggg gagcgattta 2365141 acacatgatt gattcttaat tgtgtcggaa gcatttcaga ggcggcgatg accgcttgat 2365201 tatttccatt gaatccagca tgcgcaattc ctttcagtga gcccagaaca aaaatgttcc 2365261 ctccggccct gactgttccg ccgggattca cgtcaccgat caggagcaag tcgcctttta 2365321 cctgcagcac ttggcctgaa cggacaattt ttgaaacaga aataatttcg gcttcctctc 2365381 ttatctgctg tgcttctttt ttagtaatga cttcactgtc aatagaatga acaaacaaat 2365441 ctttctttga cgcaatcaat tcggttagct gttcctcttg ctccttatat aaaaagcgat 2365501 ttcccagctt aacatgaacg ctgattttct ggccttttcc atcggtatat tgttcaattg 2365561 acagcatatt ctgaagacca tcgagaagct catcaaaaga acacgcatca tccagatgca 2365621 atgttagtcc attctttgtt ccttttattg ttacatattg ctgctttttg gtcttcacaa 2365681 tattcacctc aacaacatac tcatttcgtc aaaaaaagat aaaatccttt ttactcatct 2365741 ctcaattctt tctttagact cataaaaaac aatctaaatg gcagaacaag aataagagct 2365801 gctgcaatat ttaataaaat tgtcggtata aaccggtcaa gcacaaatcc gttaaacgtc 2365861 ataatgtctt tatgaatcaa agactgaatg ccgaatacgt aaaattcgag cagacagaca 2365921 gccagaactg ctatcaatat cactacaaat gcgtttgtat gcaacacttt aaacgctttt 2365981 gaagccaaat agcatagccc tgcaaaacca aacatgtaaa cgcctaatag acttgtatag 2366041 ttcatgtcat atagaaagcc aaaaataaat ccgtaaatca tcgcgtgttt ttggttgata 2366101 aaagccgaca tgaatatcaa tacaagcatc aaaaaacgcg gggcgagcac ttggtcatct 2366161 gtaacgaaag gaaaatgcac caaatctgta aaaatgcttt ccgcagaaaa aacaagcatc 2366221 ataacgaaag ggagaaggaa acgtttcacg atccttcctc ctctgtatcg acagtcggca 2366281 cgtcacggtt aacaacgatc acattattta aatctgtaag gtcagccgca ggttttacat 2366341 aagcaacctt cgttaatcca taggaatctg actcgatatc agtcacttca ccgattgtca 2366401 gcccttctgg gaaaacaccg cctgtccctg atgtttcaat aagatcgcct tttttcacgt 2366461 cttgtttatc cttacgctca ataattgtca tcttaagacg ttttttctct ttgtcatatc 2366521 cttcgatcaa gccgtagcct ttgctgcctt tttttccgga aatttttgtc gcgactctgt 2366581 tattgcggtc agtatcgctt aaaagctgaa cagcagacgt aaaattgtta agtccggagc 2366641 ttttgatctt gccgattaat gcgccttttt cgtttgtaac ggccatatct ttcgctacgt 2366701 tttgctgagt ccccttgtta atggtgacct gtttcgccca attatcaggg cttctggcga 2366761 tgaccgttgc taaaatcggc ttgtaatctt taatcgattt gacatggcca agctcgtcac 2366821 gcaaggattt gttttcttct tcaagctctt gaagcttggc ttcatattgt gtctgtccgt 2366881 caagtttttc tcttagacgc tcgttttctt tgtatgtgtt ttttaaatca ttgatgttct 2366941 caaatattcc tgcaaaaaat tcggcaggcg tatgaaaaat attttgaaat actcccgtcg 2367001 tatcgccgat cactttctca ggccaggtgg tattgcggcc gcccttcagc gaaaatccaa 2367061 tcatagccac caatatgata atacacagaa gtaatagcat taaccgctta ttcggcatcg 2367121 tgttacacct cttctattga actcccgatt atctagtttt ccctttgaaa agatggatgt 2367181 gctccagtgc tttccctgtt ccgatcgcta cacaatcaag cggatcttcg gcgataagga 2367241 ccggcatttt tgtttcttcg ctgatgactt tgtccaaatt gcgcaaaagc gctccgccgc 2367301 cggttaacac tatacctctg tccatgatat ctgctgcaag ctcaggcggt gttttttcga 2367361 gtgtgctctt cactgcttcg acaattgtag atacagtgtc gcgtagagcg ttagaaatct 2367421 cttttcctgt aatttcaatt gttttcggca aacctgtgag caaatcgcgg ccgcggattt 2367481 ccatgttgtc ggattcttca ggagcttctg cagatccgat ttccatttta atcgcttcag 2367541 ccgtacggtc accgatcatc agattgtacg tttttctgat gtagttgata atcgcgtcat 2367601 ccatctcatc accggctaca cggattgact gagacgttac gatgcctccg agggaaataa 2367661 tcgcaacttc tgtcgtaccg cccccgatat caacaaccat gcttccagtc ggttcccaaa 2367721 ctggcagatt ggctccgatt gctgcggcaa aaggctcttc aatcggatac gcgtcacgcg 2367781 ctcccgcctg tcttgtcgca tcgataacag cgcgttcttc aacagctgta atgcctgatg 2367841 ggacacatac cattacatat ggttttctgg caaacatgcc tttatttttt atggcctgat 2367901 tgatgtaata tttcatcatc gtcgccgttg tttcataatc agcgataacg ccgtctttca 2367961 tcgggcgaag agccaccacg ttgcccggtg tccgtccaat catatttttc gcatcatttc 2368021 cgacagcgac aatcgatttc gtatccgtct gcaaagcgac aactgacggc tctctcacaa 2368081 caattccttt tccttttaca aaaacaagcg tattcgcagt tccaagatct ataccaaggt 2368141 ctctagcacc aattccaaac atatgtatgt atcttccttt cttaaagcaa aaatacccta 2368201 aagggaaaaa ctcataaact ctattatagc ttaattcgac gaaaaaaaaa gtgttacaaa 2368261 tatccttttt cctttaaact cacaaatttt ttatccccga tcaccaaatg gtcaagcagc 2368321 tcgatgccaa tcaggtttcc gcattcaaac agccgtcttg tcacttcaat atcttccctg 2368381 ctcggcgtcg gatctccaga aggatgatta tgaacacaga taaaggaagc ggcagatcgt 2368441 ttaaacgctt ctttaaacac ctctcgcggg tggacaatag atgaattcag gcttccgata 2368501 aatacggtgc gtttatggat gacttgattt tttgtattta agtataaaca gacaaaatgc 2368561 tcctgggtta aaaagcgcat atcctccatg acaagattag cgccgtcttc cggggagcga 2368621 ataacgaaat gttcttcgtt ggctaattta tgaatccggc ttccaagctc aactgctgcc 2368681 agtatttgaa tcgcttttac cataccgatt cccgggatgc ttgacagctc ttcaaccgat 2368741 gcttccttga gcaggcgcag cccgtcaaat gagcgcagca gccggtttga caggtccaaa 2368801 acagattcgt gtttagtccc tgtccgcaat aatatagcca aaagttcatg attcgctaag 2368861 ttctcggctc cgactttcag gagccgttcc cttggctttt ctttcattgg gaaatctttg 2368921 agttttaatg gcagatcgtg tatgaccaag cactcctttt ctttcccttc ccgtttatag 2368981 aaccgtcatg cccttatatc aaaatggcga agagctctca ttgtttttga tataggaagg 2369041 cccatgactg aataataatc tccgtctatt ttctttacaa aaagcgcgcc tcttccttgg 2369101 atgccgtatg cacctgcttt atccatcggc tcttttgttt caatatatgt ccaaatctct 2369161 tcttcactga gggaccaaaa cgcaacttct gtcttatcat aaaaagtctc gctgtgattt 2369221 tcagcttgaa tgctgaccgc ggttattact gagtgacttc ggcctgaaag cctccgcagc 2369281 atagaagcag cttcttcttg atcctgcggt ttgccaagac attcgccgtc aaggcatacc 2369341 attgtatcag caccgataac gattgcatgc gggtggagat cagctacagc cttagctttt 2369401 tgttttgcca accattggac gttttcttct ggtgaaaagt ttcgatttaa tttttcttct 2369461 acttcactga caataatgga gtagggcagc tggagaagat cgaggagttc tttcctgcgc 2369521 ggagattgtg atgcaagtat tagcggtttt gtcatgttcg tcatcctttc agggtttgct 2369581 taagaaaaaa agatactcgt ttatcctacc aaatcacgag gcttgtcaca atttcagaaa 2369641 aataactttt tcatgacaaa ataaaaaaag cctgtcacta aaggacgaag gctcagggca 2369701 ctatctctta ttttacgacg gctaacagct cctgctgagc cttccacccg gcttcagcac 2369761 ttggatcctc taattccttt aaagcctgca aaatcgcttt tttctctcct gtttctgacg 2369821 cttttgtttc accaagcgac ttttctattt tctctacact cgcttttgta atgtcttcgt 2369881 cgagaatcgc ctttgctgca agctccgctg tttccttaaa agaatctgtc atatctgact 2369941 ctattgataa ggaaagctcc ttgcctcccc aggcttcaaa atcactgtcg attaaaacct 2370001 gtcctaactg ctgtgagacc tccttttcac ttgctaagcc tgcaataaca tacgtatacc 2370061 cgtcatcctt tgacagtgac acggcggaat atcctttttc ggtcaattgt tctgttaacg 2370121 tttcggcgcc cttttcattt gaaaattttc cggcttgcac agcgtatgtt ttgtatgtac 2370181 cttcagtttg tgccgcttgt ttttctgcgc ctgaggtttg tttatcagca gaagtatccc 2370241 ctgcttttgc cgtttggctg cctaaagaat cctctaaaga ggccggtgct gacgcttctt 2370301 tattccccga tatgtttaac gcgaataacc ctaatccagt gccaatgaca gccgcgaagg 2370361 caatcgtcgc ggccactctt tttaccggtt tggcagcccc ggtctttcct tttgcgtaaa 2370421 gctttgtttt tttcttttga aaaggaggaa caactttagg gtcctcttta aacaccttgt 2370481 cctcctcgga atcccaattg aattcatctt catcagggtg ttcctgggat gccgcaacct 2370541 cttgttctgc ctgtcttttt tcctcccaat ttgaaaatgt catgctttta ttcgcctctg 2370601 tctcaggcgt ctcttgttcg taaaccgtct cttcttttcc attaatcgtc accttgaggg 2370661 ctttttctgc ggctttactg ttttttttat tctttctttt tttcaattcc gcttcctccc 2370721 ttcatttgct tgaccgttct tgtcggcttt tcatgctaca cactttagca caggcaaaga 2370781 aaaaaagaac aagacttttg tcgccttgtc caaaaaacgt tcgtcaaatt tttcagcagt 2370841 cagcccaatg ccattttgat ataaaaagaa atgatagagt caccgtataa ataggctaaa 2370901 atgctccctg cggctatagc gggggcgaag ggaagcggct gccttttagc gagtctacca 2370961 gtcagaacag ctgccgctcc atataatgca cctatcaaaa ctgaaaagaa aaaggcagct 2371021 gccagcattt tcacaccaag cacaaagcca atcaccgcaa ataatttaat atctcctccc 2371081 cctactcccc catgggtgat tgcggcaatt acagccagaa acaaaaatcc ggctgccgca 2371141 cctaacaggc ctgcatacca ggaatcaagc ggagaaatca atctcgcggc cgccaaaaag 2371201 ggaagaaaga aaatcaatat tcgatttgga atcagcataa aatgaatatc tgtcactgca 2371261 acaataatga gaagagagat aaacaccaca gcgggaaaca gttccagcga tatgccaaag 2371321 cgtattcctg cggcggcaaa taaacacgct gtcacaagct ctgctgcggg atacataaaa 2371381 gaaatcctat gcccgcagct tttacattta cctttttgaa ataggaatga caggatggga 2371441 attaattctg caggagttaa tgttcgccgg caaaacgggc atgatgaacg gggcgcaata 2371501 atagatagat gtaaggggat acggcacccg gccgtatagt aaaaagaacc aaggataagc 2371561 ccgaagataa aaagaatgga tagcatagac aacacacctt tactcattga gttctggtat 2371621 ggattgtagc aaaatggaca tcctgagctc caattgggaa tattcaattt tacacatgaa 2371681 aaaaacggca gaatcttttt ttgattctgc cggagccgga tgcttttatt tcaacctttt 2371741 tcgaatgtca gaaataaagt aaagagatcc ggtaatcagc acaatttcat ttgagccctt 2371801 tttactttct atgaatttga ttacatcgtc tggatcttca ctccagcttt tattgctgat 2371861 ttcacttgca tcatagagat cttttgcaag ggaagcacgc gggaaatcaa aagaagcaaa 2371921 atgaatcgca tgagcaatgg tttccagtct tttaatcatg ttctgatacg gtttgtcctt 2371981 taacgcgcta aacaccacag aaatgcgtga attggcgaaa cgctgcttca tcgtttccgc 2372041 cagcttttca acaccttctt cgttatgcgc accgtctaaa tataccggag gatgttcctg 2372101 aacaagctct aaccgtcccg gccaagcagc cttcacaagc ccgctcctta acgcttcgtc 2372161 actgatatgg gcgatattct ccttattgag ccactccgca gccaaaatgg acaaagcagc 2372221 attttgtctt tgatgggtgc caatcagaga tgtccgaata tcttcatagc atttctcttc 2372281 cgttttgaat gaaaactgtt ctcctgcagg cagagcctct tcattgaaaa taacacatgc 2372341 atcatgcaat gactggaacg gcgcagcatg ccgttcggct tcatggcgga tgacctgtaa 2372401 agcttccggc tgggtaactg ctgtaacgat tggaatacct tctttaataa tgccggcctt 2372461 ttctcctgca atttcttcaa tggtgtttcc caaaatgttc atatgatcgt gtccgatgct 2372521 tgtaatcaca gttaagagcg gttcaaccac attagtagaa tcgaatctac cgcccagacc 2372581 tgtttcaaaa ataacaaaat cgaccttatg aaactctgca aaatataaaa atgcacaagc 2372641 tgtcataatt tcaaattctg tcggctgtcc gtattccgtt tgatcaaggg cttcaacgtg 2372701 cggtttcatt tgattgacga gtgctgtcca ttcctcatct gaaatcggta tcccgtttac 2372761 gctgatccgt tcattaaacg taataatata aggcgatgta aatgttccaa ccgtatatcc 2372821 ggcttcctgc agcatagaac ggataaaagc gacagttgat cctttaccgt ttgttcctgc 2372881 gacgtggaac gctcggattt ttttttcagg atgtcctaac cgcgccatca gctgtttcat 2372941 tcgaccaagt ccgggcttca ccccgaattt cagcctcccg tgaatccagc tgcgcgcatc 2373001 ttgatatgca gtaaacaatg ataatcccct cttttataag acaaggcggt ttctctagaa 2373061 accgccccgg cttttcatta acccttcagc tcagccattc gtttttgaac agcgtcacgc 2373121 ttcgccacat aatctttttc tttttcacgt tcttcatcaa ttacgtgtgc aggcgctttt 2373181 ttcataaatc cttcatttcc aagtttcttt tggacacgct caacttcttt tgtcagttta 2373241 tcaaattctt tttgcagacg ggcaatttct tcatcaatat tgattaagcc ttcaagcgga 2373301 agaataacct ctgctcctga gacaacggcc gtcatcgcct tatcaacagc ctcaatatcg 2373361 gtgccgattt taagcacgct cggattcgta aagcgttcaa catatgaacg gttcgcttcg 2373421 aggcgggacg ctatttcgtc tgtgcttgtt ttaatgtaca gttcaacctg cttgctcatt 2373481 ggcgtattga cttcactgcg gatattgcgc acagaacgga tcagctcaac aagaagcttc 2373541 atgtcagctg ccgcttcagt atcggtatgc tccggcacta ctgcaggcca ttgacttact 2373601 gtaatcgatt ccccttggtg aggaaggtgc tgccaaattt cctccgttaa gaatggcata 2373661 aacggatgga gcagacgcat cgtttgatca agtacgtaag caaggatgga acgggtagtt 2373721 ttcttagccg cttcgtcttc tccataaagc ggaagcttcg ccatttcaat ataccaatca 2373781 cagaaatcat cccaaataaa gttatataaa tggcgtccta cttcaccaaa ttcatatcgg 2373841 tcagcaagct gggtcacgtg ctcgatcgtt tcatttaatc gcgttaaaat ccacttgtca 2373901 gcgactgact tttcacctga cagatcaagc tcatcgtacg tcatgccatc catattcatt 2373961 aatgcaaaac gggaggcgtt ccaaatttta ttggcaaaat tccaggtcga ttccactttt 2374021 tcatagctga agcgcagatc ctggccagga gagcttccag tcgcaaggaa ataacgcaga 2374081 gaatcggctc cgtacttgtc aatcacatcc atcgggtcga caccgttgcc aagagattta 2374141 ctcattttcc ggccttgctc gtcacggatt aagccgtgga ttaaaacatc tttgaacggg 2374201 cgctcgcctg taaattcaat gccttggaaa atcatgcgtg atacccagaa gaaaatgata 2374261 tcgtaccctg tcacgagaac atctgtcgga tagtagcgtt taaagtcttc agccgttaca 2374321 tcaggccagc ccattgtgga gaaaggccat agcgcagaac tgaaccatgt atccagtacg 2374381 tctgtatcct gttcccaatt ttcgctgtct tccggcgctt caagtccgac atatagctcg 2374441 cctgtttctt tatgatacca ggcaggaata cgatggcccc accacaattg acgggagata 2374501 caccagtcgc ggatattttc catccagtgt aaatacgttt tttcgaaacg gtcaggcaca 2374561 aagttgacct tttcttcttt tttttgcagc tcaatcgctg catcagcaag cggctgcatg 2374621 cgcacaaacc attgtgtaga aagataaggc tccacaacag ccccgcttcg ttcactatgg 2374681 ccgacagagt gcatatgatc ctcgatcttg aagagaactc ccgcctcctg taaatctttc 2374741 acgagctttt tgcggcattc aaaacgatcc ataccttgat attggagcgc attttcattc 2374801 atcgtgccat cttcattcat gacaaggatg cgttctaaat tgtggcggtt gccaagctcg 2374861 aagtcgttcg gatcatgagc aggcgtaatt ttcacggcac ctgaaccaaa ttccatatca 2374921 acatagtcat caccgacaat cggaatttca cgatttacaa tcggcaggat caccgttttt 2374981 ccgataaggt gtttatagcg ctcgtcttca gggtgaacgg caacagctgt atcaccgagc 2375041 attgtttcag gacgtgtcgt cgcaatttca attgagcctg aaccgtcagc aagcggatag 2375101 ctcatatgat agaatgcgcc ttgaacatcc ttgtaaatca cctcaatgtc ggatagggct 2375161 gtttttgtcg ctgggtccca gttaataata tattcgcctc tgtagatcag gcctttttca 2375221 taaagcttaa cgaatacttc ccttaccgct ttgctcaagc cttcatccag cgtaaaacgt 2375281 tcacgggaat aatctaggcc aagacctaat ttcgcccact ggctgcgaat aaagtcagca 2375341 tattcttcct tccacttcca cgtttcttcg aggaattttt cacggcctaa atcgtagcgg 2375401 gatttgcctt cttcacgaag tttcgcctcc actttagcct gtgtcgcgat gccggcgtgg 2375461 tccatgccag gaagccacag cacatcatag ccctgcatgc gtttcattct tgttacaatg 2375521 tcttgcagcg ttgtgtccca tgcgtggcca aggtgaagtc tccctgttac gtttggcggc 2375581 gggatgacaa cagagtatgg ctcttttgtc tggtcactgc ccgcttcaaa aaatttgcct 2375641 tttagccaaa aatcatatcg gtctttttca accgctgccg gatcatattt cgtcggcatt 2375701 gtttgttcat tcgtttccat cataaccctc cagcatgttt aaaaatggct gagaacgaaa 2375761 aaagagctct tcatccctgt aaaaggacga aaagctcttt cgcggtacca ccttttttca 2375821 tgaactcaat cagttcatgc acttataacg gataacgggt gtttcccgaa tttctctact 2375881 cttctttcaa gaaattatgc tcccgggcga ccttccaatc agacaacata agaagccttt 2375941 cagcaaacgg cttctctctc tgcatgcgcc ttttttgtac tcttcccgtt ctaagcaggt 2376001 gtatttatca gctcattgta tacattattt atgttcttta ttatagtaaa agtgtttttg 2376061 attcgtcaat catcttttcc aaaaacaccg ctttctatac agatgggcag gcacctattg 2376121 cccaagttta catatgatgc ttgtaaatgc gtagaggagg atgcaccgtg aagaaacgtt 2376181 tcagctctta ttcgctgccg ccatgggtaa ggcaaattcg gcttgtatcc gcacaagtga 2376241 ttattcccat tacgattttt caaggaatca gaaccatttt ctttccgaca acctttgatg 2376301 ttttgctgct cgcaatccta atctttttag cttgcgccct tcatttagaa tggatataaa 2376361 caaacaagtc cgcgccatta agacgtggac tcgttttcag cctgaaattt tttctcttgt 2376421 tcaatctgat gaattttcat cacaaacggc tctatgtttt tcatttgcca ataagccttt 2376481 aataattgtg tacattcctc tttttcatgc tgtcttttcc cagtttgata accgttcagc 2376541 accttgtaca tggctgccgg atatgccata tagctgagaa aaaggctgac ttccgcttca 2376601 cgcaaaggga atgatttcgt atatccataa aaccattcga cgcattccgg acaagctttc 2376661 ggaaagcctc tgaacatttt tgtataaaag ccgagcaggt cgttttgcgg cggaccgaca 2376721 gatgctcttt cgaagtttgt aaaatatccg gtcccggcat cattatacag aaaatggtgt 2376781 atagacaggc tgccgtggtt cattacaacc cttgaaacgt ccttttcctt tgcggactca 2376841 taccagtcct ccagccgttc cagcgcaaag ttcaccgcgg aaatggtttc agaaaaatag 2376901 gttatggcct ggagttcaaa gggagaaagg taccattcct tctccgctct atccacaaac 2376961 tgctcataga aaattttatc ttgttcccac ttttttttcg tttgcccgta ataacgttca 2377021 atctcatcac gtctaacctt tagttcctgc gcggttctct cgtgaagacg ggctgtttct 2377081 ctaaataaat aagcatgttt ttgatcccgt tcttcctctt ggtcaaattg gagccaaggc 2377141 attaaatagt agatatctcc gtattgtatg cctgctgaga aaaactcacc gctatttgtt 2377201 ctgtaaacgg gaacgaatga acgaaagcct ttttcctcaa tcgccaccat atgatctgta 2377261 aaatgcttgc cgcgaccttc tttcaatttt ttcagggcaa atatgccgta gtctgtatac 2377321 actttccaaa caagaggact gacaggctca ataaattgag cagtcagtcc gtattcctga 2377381 agaaccgatt gggtatcttc catttcattc accacatttt ccgatcactt acggtttacg 2377441 catggctatt tttatattga ggaatataga gaatctgtcc tgcttttaat tcatcatcca 2377501 aggctaaaga attcatcctg atcagctgct gggatgtaat ttcataccgt tcgcataaac 2377561 gctcgatcgt atcttcctgc tgcacaatac aaattttcat tctcgaaaac tcatccgctt 2377621 cttttgtaaa gagttttgtt aaataaagag aattatcact ttcctttgtt tgaggttcct 2377681 tcgtttcagc agcaggagca accctaggaa cagcatccgt ttccttcctt tcagtctcag 2377741 aagattcagg cagctggaag gattgaaaag gtgtttcttc cttaggctct tcagctgatg 2377801 gtgtttttct cacttcaatt tcgaagctct cttcctcttg ttcttcctcc tccagcagct 2377861 taggcgctga ataaaaagaa tcctcctctt cttgttcagg caggaaggta cggtatgccg 2377921 gttcaggcaa ttcttcttga gatgcctcct ccgagcttgt tttttgattg aaatggaaat 2377981 gtaaatcggc attgtcattc tccatatata cagctgaagc tgtttctctg ctatcttcta 2378041 tggagagagc ggcctctgat acactctcca aagcttcatc cggttccgcc tcttcttggc 2378101 aaagcgcagg atcagcctga tccgattgag ctgcttcttc attttgagcc tcttggcgca 2378161 gcgcatattc atgattagga gacactgttg tttcctcttt ttcctttgca atcacagtct 2378221 ctgaatgaag ctcagcttcc aaagcaggcg attcttctgc tccaacgtgt tcacgaagct 2378281 cagtctccgc tggagagtct gcttcttcac gaacatccgc tattgcagct gccggctctg 2378341 ccgtttcttt ttttgcttta acgatctctt gaatctctat ttctgaagga tcaggttctg 2378401 gctcagattc ttctgtttcc gattcagcac gaacctccgt ttccggcaca gcaagctctt 2378461 ctgactcttc ttcctctttc acatcttctc tggcctctgg ttctgaagca accgattcag 2378521 gcggctcaga ttctgctttt tctgtctcca gttcttcacg gagccccgct ttcgagataa 2378581 aaagttctgg cggttcggct ggcggttcat gctgaagaac tgcttcctct gccgatgatg 2378641 cacccggttc ttctactaca ctatgtgccg gcggctctga aagctcttcc tccctgaatg 2378701 ccgcaggagc ttcatataaa ggtatctccg gctctttgtc ttgcgtatcg tccaaaagcc 2378761 cttcgatcgc taaatcagct tgaattgtta aaatgcgcga atccgtcaat tgatagtcaa 2378821 atgcgtcaat aaagacgaag acatcctgta aatggctcac tttatttttc ggaatggtaa 2378881 tatccacagg aaaacagtga gtcagttccg cacttccatc ctctctcttt ctgacttgtt 2378941 caacaaaccg cttatctgta taaatctctt cggtatgttt gttttgatct atgttgtact 2379001 cacctgtaag ttcaagcgat cctatgattg atacataatc atttacttcc tgaaccctaa 2379061 tatcaggatc taatgaaata gaaagcagtt cagaaacttc ctgtcctttt tggaaacaga 2379121 tcgattcttc tacagaaaat tgcaatcgat gattttgcgg caagttcata tcctcctttc 2379181 atctaatcct taaaattaga tgtcactaaa ggtgtatgta tgaactggag aaaatatgag 2379241 tgggagagca cgaaaaaacc ggcacaagga gtccttgata ccggttttca ctcttatctg 2379301 cggctgatct cagcaaatac tttctcagct gcctggattg tgttttcaat atcttcatca 2379361 gtatgggccg ttgagaggaa aagaccttcg aattgtgatg gcggaaggaa taccccttca 2379421 tttgccatcc ctttataata gcttgcgaac agcttcaaat cagatgattt cgctgtttca 2379481 taattgatga ctggttcgtt tgtaaagaag aaaccgatca tcgaacctgc acggttaaag 2379541 gtatgcggaa tgccatgagc cccggcggtt tttgaaattc cttcttccag tctgtcgcct 2379601 tttttgatga aattcttgta ggattcaggt gtcagctgtt tcaatgtctc taagccagcc 2379661 gtcatcgcaa gcgggttgcc tgacaatgta ccagcttgat agatcggacc gcttggagcg 2379721 atctgctcca tgatttctgc ctttccgcca taagcgccga caggaagtcc gcccccgatt 2379781 acttttccta aacaagtcag atcaggcgtt acgccgaagt agccttgagc gcagttataa 2379841 tcgacccgga agccagtcat cacttcatca aaaatcagca gggagccgta ctgctcagtg 2379901 atatcacgca gaccctgaag gaaaccttct tgcggcggaa caacacccat atttccggca 2379961 actggctcta caatgactcc cgcaatgtct tcaccgaatt gctggaaagc aagctttaca 2380021 ctttctaaat cattgtacgg aacggtgatg gtgtttttcg caatgccttc aggcaccccc 2380081 gggctgtcag gcagaccgag agtggcaaca cctgaaccag ctttaatcaa gagagaatcg 2380141 ccgtgtccgt ggtagcagcc ctcaaatttt aaaatcttgt tgcggcccgt atagcccctt 2380201 gccaaacgga gggcactcat tgtagcctct gttccggagc ttaccattcg tacaatttct 2380261 acagatggca cacgatcaat gacgagctta gccagttcat tttctacttc agtcggagca 2380321 ccaaagcttg tcccgtattc agccactttt ttgaggcttt ctacgacgcg gtcatttgta 2380381 tgccctaaaa ttaaaggccc ccatgacaag acgtagtcaa tatattcatt cccgtcaata 2380441 tcaaagattt tcgagccttt tccgcgctcc ataaaaatcg ggtccatgtc taccgattta 2380501 aatgcgcgaa cgggactgtt cacaccgccc ggcatgagtt tttgcgcttc tttaaaagcc 2380561 gtttttgatt tttcatagct tctcatctgc ctcaactcct gtcaactgaa taaaattact 2380621 ccgcaagcca tttcgctgcg tctttcgcat gatacgtaat aatcaggtcg gcacccgcgc 2380681 gcttcatgct tgtcaaaatt tccaacacaa tttctttttc tttgatccag ccgttctgcg 2380741 ctgcagcctt caccattgaa tactctccgc ttacattata agcgacgagc ggcaaagtaa 2380801 actcattttt tacgtcacgc atgatatcca tataagaaag cgaaggtttg acaatcaaaa 2380861 agtccgcgcc ttcctcaaca tctgattgtg cttcgcggag tgcctccata cggttggcag 2380921 ggtccatctg atatgttttg cggtctccga attgcggtgt gctgtttgct gcatcacgga 2380981 acggaccgta aaactcactt gaatatttaa cagcgtaaga catgatggga atattgacga 2381041 atccttcttt atcaagtgct tctctgatca ctgtaacaaa tccgtccatc atgtttgatg 2381101 gcgcaatgat atccgcacct gctttcgctt ggctgacagc tgtctgcgcc aaaagctcca 2381161 gcgattcatc attgagaatg actccgtctt tgacaagtcc gcaatggccg tggtctgtat 2381221 attcgcacag gcacgtgtca gcgacaacaa ccatttcagg gaagtgttct ttaatttctg 2381281 tgatggcttt ttggacaatt ccgtgatcat ggtacgcttg tgttccgcaa tcatcttttt 2381341 cttccgggat gccgaacacg ataacagatt gaatgcccag tttgaccagc tccgctactt 2381401 catccttcaa taaatctaat gatacatggt gaacatcagg cattgacgga acagcttttt 2381461 tgccttccag cccttcaacg acaaaaatcg gatatataaa atctgatgga tgcaaacgtg 2381521 tttcctttac catttctctc attgcttttg atgtccgcag gcggcggtgt ctattaaatg 2381581 attgactcat attctctctt cctctcttga catgctgcac attaactcaa gcatgccatc 2381641 tattgtaaat gtatcaggcg tatgcgatgt gatgccgtac gtcagaaggg catcatttgt 2381701 taaaggccca atgctgatac aggccgtccc attcgccttc cactttttta attcttctcc 2381761 caagacatgc ataaacgtat gtacggttga tgaactcgta aatgttacat agtcaaagga 2381821 atattgaccc gcagcgtctt tcaatgcctc aatgccttct tcatccggaa tcgtttcgta 2381881 gagaacccat tcctttactt caaaaccgag cgggacaagc tcttgtttta tcacatcacg 2381941 tgacaaattc cctttcatca cggtaatggt ctcccccggt tcagcatgct gcttaagagc 2382001 gtcagccaat tgttcagcaa tatactcctg tggcatcaca tcaaccgata cgttatgcat 2382061 ttttaaacgg cgcgcggttt tttcaccgac ggctgcaatt tttttatgcg cagggagaat 2382121 aagctgattt tccttcagat aagaaaaaaa gaagtctgcc ccgttcacac ttgtaaaaac 2382181 aagccagcct ggcgcggcaa gatcctctct tacctgttcc gcaacatcat tcggcaaagc 2382241 gcggcgaaac gtaatcaaag aggttaaaac cgctttaccg ccaagcgcct ccactttttg 2382301 ctgaaatgat gctgcctgtg ccttattccg ggtgacaagc actgtttttc ctttcaacgg 2382361 aaaatcattt tccatcctcg tcaagctccc gttttacacg atcaattaaa tcttttgctc 2382421 ctttgtcagc cataagagcg gcacagcgct ttcctacttc ctccggatcg tttccggtga 2382481 cggtttcttt aaaaatgatt ttgccgtcag gtgaagcgac aagacctgtc atttcaattt 2382541 catcctgtcc atttaacacg gagtagcccg cgatcggaac ctggcagccg ccctccatcg 2382601 cgtttaaaaa agcacgttcc gctaagacag tccgttttgt atattcatct gtaaactgag 2382661 aaaacaacgc caacagctct tcatccgatt ctcggcactc aatcgccagg gctccctgcc 2382721 ccacagcagg caaacagcgc tcaggctcaa ggaattcggt tacgacatct tgcttccaac 2382781 ccattctgga aaggccggca gccgctaaaa taattgcgtc ataatcctct gtttccagct 2382841 tttgaagtct tgtatctata ttacctctaa tccatttaat tgtaaggtca gggcgctcaa 2382901 tcaaaagctg cgcgcttctt cttaaactgc ttgtgccaat gacagcacct ttcttcattt 2382961 ctgaaagctt tacgcgattc tttgaaataa gggcatcacg cgggtcctcc cgttcaggaa 2383021 tacagccgat cacaaggcct tcaggcaaaa cagcaggcat gtccttcatg ctgtgcactg 2383081 ccatatcaat ctcttcgttt aaaagcgcct gttcaatttc tttgacaaaa agcccttttc 2383141 cacccacttt tgagagtgta acatcgacaa tccggtcgcc ctttgtcacg atctctttaa 2383201 tttcaaaagc aaacgaagga ttgatttcct tcagtttttg aataacccat tttgtttgag 2383261 tcatagcgag tttgctccgt ctggaaccta ctttaatcgt tctcatcatt tctttcctcc 2383321 cgaatctgct tgggacatcg tttaactgaa ccaatggaat tgcgacaggc ttccaagcag 2383381 gaaataattg atcatcagca ccagaaaaca agccgtattc cacagtgcag cgacctttcc 2383441 ttgcagctcc ttaatcagcc tgatataaag ataatagctg tacagcagca ggacgacaaa 2383501 cgaaccaagc actttggcgt caaaccaata cagcgtttct agtgagacat acgcccaaat 2383561 gacgccgaga atcaaactca gcagcagcat cggaacccca atgacattta aaacatacgc 2383621 catataatca agcttagata aatcttctat tctcaacagc cattttcccc actttttctt 2383681 tttcagcaga tgatattgaa acatatatag cacagaaaaa acgaaagaaa gggaaaaagc 2383741 gccgtatgaa agaatcgcca ttgtaatatg aatcaccaaa agctcggata caagctgccc 2383801 ggaaaaagca gctgactgct gctctgtcgg tgaaaatgtg tgaatggcga tcatagaaaa 2383861 tcctataaca tttgtaaaaa acacgataaa gtcaacacgt aaaagctttg tcagtacaag 2383921 tgacagcgtg acaagcaccc aggcataaaa ataaagtgcc tctgtcacat ttaataccgg 2383981 aaaccgcccc gtcacccaca taaaataggc caaatacacg gtttgcagag tccagacaat 2384041 agaaagcaac cagaaggcca tttttccagc cttccggttg tgttgaagaa aatctataaa 2384101 ataaaagagt acacttaacg cgtaaatgac gattgtcccc tcattaagtc ttgccattgc 2384161 agtatcaatc attcagcttt cactcactta caagtgggct aaagcccgct tttgattcag 2384221 ccttcttaaa agagtggacc ttctggctgc tttcaacggt tttcatcatt tgacggcccg 2384281 cagcttcttc aatatcaaaa atctgcataa acaacgcgag cttttcttca gaatcagcat 2384341 ctgccgcaag ctctttcacc tttaaaatcg gatcacgaag catttggtta ataatacttt 2384401 tggtgtgttt gttcaacagt tttttctctc ttgtgcttaa gtgaggcagc ttacgctcaa 2384461 tgctgtccat cgtttctgac tggatggcaa gcgccttttc gcgcaatgca gaaataacag 2384521 gcacaacacc aagtgtattc atccattgtt taaattccac aatggtttct tcaattaaca 2384581 gttcaacttt ttcagctgtt tctctccgct ctttcatgtt cgcttctaca atgccttcca 2384641 gatcgtcgat atcataaaga aaaacacctt caagatcatt cagcgccgga tcaagatctc 2384701 taggcacggc aatgtcgacc ataaacagcg gacgtccctt gcgaagctta ttcgcgtttt 2384761 ccatcatctc tttggacacg acaaattcac ttgcaccggt tgaactgatt aaaatatcag 2384821 cctccgcaag cgcgctttca agctgattca agcttctcgc ttcacctgaa aaacggtctg 2384881 caagctcctt cgctttcaag tatgttcggt taatgacagt gaccttgccg attccctgtc 2384941 cgtgcaggtt ttccgcagca agctcgccca tttttcccgc accgagaatc aatatgtgct 2385001 tgcttgaaag atttccgaag atttttttgg caagttcaac tgcagcatag cttactgaca 2385061 ccgcatttga gccaatgtct gtttcggcgt gagtccgttt gcccactgta actgcctgct 2385121 taaacagctc attaaaaata gtcccgatcg ttttttcttg ctgagctgtt ttaaagctgt 2385181 cgcgtacctg tccgagaatc tgcgtttcgc caatcaccat agaatcaagt ccgcaggcta 2385241 cacggaataa atgctcaaca gcggcatcgc tctcataaaa cgttaagaac ggtgacagct 2385301 cttctttgct taattgaaac caatcagcta aaaacttttt tatataataa cggccggtat 2385361 gaagctggtc gactaccgca taaatttcag tgcggttgca ggttgagaca atgatgtttt 2385421 caagaatgct tttctcttct ttcagctgca ccattgcttc tgccagctca ttcggctgaa 2385481 aacttacttt ttcacgtatc tcaatagggg cggatttata atctactccc acaacaagta 2385541 tatgcatcgc tctaattaca cccccaacac ccaatcttaa tttataatca ttctaacata 2385601 gaactcatta tttataataa ttataacata gtttctttca caaaatgtga acagatttta 2385661 aaattcttat gctatattag aaaaagcttc agggaaaaga agcattccta ttgacaatac 2385721 caaaaacagc agaaatttac tacacatcag ctctaaaaaa caagaaggtg atatgcatga 2385781 aacaaaaatc aattttattc ccttgtctgc tgcttgccgc ttctgtatat gcatggctag 2385841 aaagcggcca agccgaactg ttttcagggc aggatcaatg gcctgttctc ctcatgctgt 2385901 taggcgcagc ctttgtatat caaggaaaaa aagaagccgt cacaccccat ttttttatcg 2385961 gtttgcttct cttcgggatc ggtttacact tttttgccaa gccgaaatgg gtatggtggc 2386021 cggatgattt tgaaatgctc ctctttatga tcggcttctc acttctcgtt tcaaccgttc 2386081 aaaaaaaaga atatgtatat gaagctgtgt cgatgatttg tttttccctg tttttgtact 2386141 ttttcaaaca aattatggca tggcttgagt ctgcgcatat tccaacagcg cttctgaagg 2386201 agtattggcc gtttgtcttt attggaatca gtttattgtt attattgata aaacgaaaaa 2386261 aatctatacg ataaataaaa ccggtagagg atcctctacc ggtttatcat ttttttgatc 2386321 gctccccaag cttcgtcttt tccctttttc gtttctgaag aaaagaggat cagctcgtct 2386381 tccggatcaa tatttaatgt ttgtcggaca accttcgcgt gtttgtccca tttacctttc 2386441 gggatcttat ccgcctttgt agcgataaca ataacaggaa tgccgtaata ctttaaaaat 2386501 tcatacatct gtacatcatc attagatggc gcatgccgca aatcaacgat ctgcaccaca 2386561 gcttttaatt cctcgcgtgt cgtgatatag gtttcaatca ttctgcccca tgcttcacgc 2386621 tcagactttg acactttggc aaaaccgtag cccggcacat ccacaaaatg cagctcatca 2386681 ttgataatgt agaaattaag cgtttgtgtt tttcccggct ttgatgacgt tctcgcaaga 2386741 tttttgcgat tgattaatga attgataaaa gacgattttc ctacgttcga tcttccggcc 2386801 aatgcgattt ccggaagccc cccttcaggg tactgttccg gttttactgc actgatcacg 2386861 atttctgact ttgtgacttt catttcttct ctcctactaa ggcatgttcc aaaacctcgt 2386921 ctaagtggga cgccaatata aatgtcagcc cctccctgac gctttccgga atatcctcta 2386981 tatctttttc attatcttta ggcgcaataa tggtcgttaa tcccgctcta tgtgcgccaa 2387041 gcgctttttc ctttaagccg ccgatcggca gcacgcgccc gcgaagcgtg atttccccag 2387101 tcatgccgac ttcacgcgaa accgcccgtc ccgttaaagc agaaacaagc gctgttgcca 2387161 tcgtaatacc ggctgacgga ccatcttttg gcaccgcacc ctctggtaca tgtatatgaa 2387221 tatcatactt ctcatgaaag tcaggttcaa tgccaagttc ttctgttttg gatcgcacat 2387281 agctgaatgc agcctgagca gactctctca taacatctcc gagctttcct gtcaggatta 2387341 atttcccttt tcccggtgaa agcgatactt caatcgaaag cgtatctccg ccaacggttg 2387401 tatacgcaag ccctgtcact acaccaactt gatcctctgt ttcagcttgt ccatatctga 2387461 aaatgcgttt tccgataaaa tcttgaaggt tcttctcagt aaccgtaatt cgttttcgct 2387521 cttcagcaac aatggctttt gcagctttac ggcaaattgc ggcaagctgg cgttcaaggc 2387581 ttcttacacc cgcttctctc gtatagtaac gaataatatc aagaatcgcc tgatcacgca 2387641 gctgaagatt gcttttcttc agcccgtgtt ctttgatttg ctttggaagc aagtgatcct 2387701 ttacaatttc aagtttttct atttctgtgt agcctgcgat attaataatt tccattctgt 2387761 ctctgagcgg gcccgggatt gtggccaaat tgttcgccgt tgcgataaac agcactttgg 2387821 ataaatcaaa ggtttcttca atatagtgat cactgaagct gctgttttgc tctggatcaa 2387881 gcacttcaag catagcggat gatgggtctc ctctaaaatc agatgacatt ttgtcaattt 2387941 cgtctaataa gaagaccgga ttcagcttgc ccgctttttt catcccttga ataatacgtc 2388001 caggcattgc tccgacatag gtccgtctgt gtccgcgtat ctctgattca tcccgaactc 2388061 ctccgagtga gattctgacg aatttgcgtc ccaagctttt tgcaattgat ttggctaaag 2388121 acgtttttcc gacacctgga ggtcctgcca aacagagaat cgggcctttc agggattttg 2388181 tcagcttctg gacagccaaa tattctaaaa tacgttcttt tactttttca agcccgtggt 2388241 gctcttcgtc caagagacgt cctgcttctt tcaaatcaag cttatcatct gtttcatccg 2388301 tccacggaag agcaaccagc cagtcgatat agttgcggat cacagagctt tccgcagaac 2388361 ttgacggaat tttttcatat ctgttcaatt ctttaagcgc tgtttctttc acatgatcag 2388421 gcatgcctgc ttcttcgatt ttttccgtca gcgtctgaac ttcgccagtt ttgccttctt 2388481 tatcgccaag ctctttttgg atcgccttca tttgttcacg caagtagtat tccttctgcg 2388541 tacgctccat cgaacgtttg acgcgctggc cgattttttt ctcaatctcc agcacttctt 2388601 tttcattatt aataaaatca atgaccttgt tcagcctgtc tttgacatca gccgtttcta 2388661 aaatatcctg cttatccttt agtttaaggg gcagatgaga agcaacgatg tctgccattc 2388721 tccccggctc ttcgatatca gtaaccgcag cgtacgtttc ggccgagatt tttttagaaa 2388781 tttttatgta ctgatcaaag tggtctagca aagtccgcat caatgcttcg tcttctgtat 2388841 cttttgaatc atcttcatga ataagttgaa tgtcaaccga cgtgtaatcc tcgtgttcat 2388901 tgtatttgac gatatgggcg cgcttgaggc cctccaccaa cacacgaatc gtaccgttcg 2388961 gaagcttcag catttgctta atttttgtat aggtgccgac agtgaaaatc tcgtcttcac 2389021 caggttcgtc tatcgaaata tcctgctgag tggctaaaaa tatcatatga tcatgcatca 2389081 ttgcctgttc aagagcctga accgacttgt cacgtcctac atctaaatgc aaaaccatcg 2389141 tcgggtacac taataaacct cttaaaggga ggagcgggat gctgcgtttt aattcttctg 2389201 ccatgtgact gacacctccg tgactttagt atgaaccatt ataatacaac tttttcatcc 2389261 ttgtacaata aacggcatgg ttccattttc tataaaacag tctcctcgta gtataccctt 2389321 tctttctgat atgaaaaagg aaaagatgtc cttcatgaaa aaaaccctat tatcaaaata 2389381 gggtttaaac ggattcttta ttgatttcga tatgaaacgg tttttgttcc gttggcggat 2389441 tcaccaaaat ttcatcaagc acttcttgga acgtcttcac tgcaataatc tcgatcccgt 2389501 caatctgctt taagatggcc tgctgatttt catatgggat aatcaccttt ttcgcaccgg 2389561 actgcttggc cgcttttatt ttcggaatga cgcctccgat gggtttcaca agaccgttca 2389621 ggctgatttc gcccgtcatc gcaacggtat tgtcaatagg aattttgtgt atcgccgaga 2389681 aaatccccgc cgccatcgca atgcctgctg acggcccatc aatcggaatc cctcctggga 2389741 aattgatgtg aatatcataa tcagaaggct tcattcccat tgtccggagc acggttaata 2389801 cattttcaac cgaacccttc gccatgcttt ttcgcctgat cgattttgat tggctgccga 2389861 tgctttcttc ttcagctatt cctgtgatgt taattgatcc tttatcttga gccgcggtta 2389921 cacttacttc gatttccaga agcgatccgc tgttaggccc atagactgca agcccattta 2389981 caatgccaac ctgtggttca acaccgattt tttgctcgtg ctttggagta agctgactgg 2390041 agtgaatgac ccattcaata tcctcaatcg taatgtcctt tcgattctcc gttacagcca 2390101 tccccgctgc gatttgaatc atattgacgg cttcccgccc gttccgcgtg tagctggtca 2390161 aaagatccag tccttcttcg gagatatttt tttcaatttt atccgctgct gttttggcaa 2390221 ccgttttcag ctcgtccttt tcaagctcgc ggaaaaaaac ctccaaacag cgggaccgga 2390281 tagctggcgg aatttcgttt ggcattctcg tggtcgcgcc aatcaagcga aaatcagccg 2390341 gcagcccatt ttgaaaaata tcatgaatat gattcggaat ttgtgtattt tcctcactgt 2390401 aatacgcact gtctaaaaag acttttctgt cctcaagcac cttcagcatt ttattcattt 2390461 gaataggatg cagctcccct atttcatcaa taaacagcac accgccatgg gcatgggtga 2390521 cagctccctg cttcggctgc ggaatcccag cctgtcccat cgctccggcc ccttggtata 2390581 tcgggtcatg gacagagccg atgagcggat cggcaattcc tctttcatca aaacgggctg 2390641 ttgtcgcatc gagttccaca aagacagcct gctctttaaa cggtgattgt ttatgttttt 2390701 ttgcttcttc caacacaagc cgcgcagcag ccgttttccc aactcccggt ggcccataga 2390761 caatcacatg ctgaggattt ggcccgcata aagccgcctt taatgcttta atgccgtctt 2390821 cctgtccgac gatatcttta aagcttttgg ggcggacctt ctcagataat ggctcggaca 2390881 agctgatagc gcgcattttc cgaagctgct ccatttcctt ctttgattct ttatctatcg 2390941 tgaccttttg tgtcctttga tttttaagca aattccaaaa atacaaaccg atgatgatcc 2391001 caaaaaacag ctgaataaat aacgcgatcc ctgtccaact catggtggtc cctcctgaaa 2391061 aacaatttat gtatccaatt cattcctctg attgctagta tctcccatag aagacgggaa 2391121 taaacgtttt tccggaagag ttgcatgcaa aaaaacctcc tgagtgttac cactcaggag 2391181 gtttgtgctt atctttatgc agatgtttta tcttggctta cctcagtgcc gtcttttaat 2391241 aagaggcgag gaggctctcc gtgtgtcaca gttgccccgg tgattacaca tttttcaatg 2391301 tcatcacgag aaggcagctc aaacatcaca tcaagcatga tgccttcaat gatagaacgg 2391361 agtccgcgtg ctccagtctt gcgttcaatt gcttttttag caatttcaga aagcgcttct 2391421 tcttcaaact caagctcaac gttgtcaagc tcaagcattt tcttgaattg cttaacaaga 2391481 gcgtttttcg gttttgttaa gatcgcaacc aatgcttctt cgtcaagctt ttcaaggctt 2391541 gcaataaccg gaagacgtcc gataaattca ggaattaacc cgaaacggag caaatcttct 2391601 ggaagcactt ttgaaagaag atcttctttc tcaagatcag cagctttatt gtcggcaccg 2391661 aatccaatca ctttttggcc taaacggcgt ttgatgattt gttcgatacc atcgaaagct 2391721 ccgccgcaaa tgaacaaaat atttgttgtg tcaatttgaa tgaattcttg atgaggatgc 2391781 ttacgtccac cttgaggcgg tacgcttgcc actgtaccct caagaatttt aagcaatgcc 2391841 tgctgtacac cctcacctga cacatcacgt gtgatagacg ggttttcaga ttttctagcc 2391901 actttatcga tttcatcaat atagataatg cctttttcgg ctttttccac atcataatca 2391961 gcagcttgga tgagcttcaa gagaatattc tctacatctt cacccacgta tccagcttca 2392021 gtcaaagatg tagcgtccgc aatcgcaaac ggcacattta aaatgcgagc caatgtttgc 2392081 gccagaaggg ttttaccgct tcccgtaggg ccgattaatg aaatattact ttttgaaagc 2392141 tcaacatcat caactttgct gttggagtta atgcgcttat agtggttata cacagcaaca 2392201 gcaagtgatt tcttcgcttg atcttggccg atgacatatt cattcaaaat ttcgcgaatt 2392261 tcctgaggct ttggtacgtc tttaaattct acttcttctt ctgttccgag ttcttcctct 2392321 acaatttcag tgcagagttc gatacattcg tcacatatat atacaccagg tccagctaca 2392381 agcttacgaa cctgatcttg tgtttttcca cagaacgagc attttaattg tcctttttcc 2392441 tcgttaaatt taaacattct ttcacccctt aatcttgtct cactttttct tttaccggca 2392501 gagcaaaaga aaatgattct tgaaacgaac gagtatgtat tgcattttac catactttcc 2392561 aaaaagacgg taacaatgtg tttctgactt gcacattcta tatgtatgac aaaaaacagc 2392621 cctgcattaa ctatattgcc ccaagaaaaa gagataactc ataattgtac aaaacaaggc 2392681 acgaatgatt cgcgccctgt tttattagta ctattattat gcaccatatt aacggttttc 2392741 tacaagaaaa tcaattgctt tgcgaacttt taaatcttct ttcatcgcgt cagtagaacc 2392801 gatggcttgt ttaatatttt caacaggcat gttgtatgct tcagccattt ttgtaagctc 2392861 agcatcaact tcctcatctg atacttcaag gttttccgct ttcgcaatcg cctcaagagt 2392921 caggttagat tttacgcgtt tttcagcatc ttctttcatt tgctctttaa gcgcagcttc 2392981 atcttggcct gagaattgag tgtaaagctc aaggttcatg ccttgcattt gcagacgctg 2393041 ttcgaattct ttcagcatgc ggtcaagctc agtgtcgacc attgcttgag gcacatcgat 2393101 ttcagcattt tcagaagctt tcagaacaag ctcttcacgc aatttagcgt cagcttcgtt 2393161 ttcttttgct tcttctaaac gtttctttgt tttttcagtt aattcagcaa gtgtttccac 2393221 ttcttcatcg atatcttttg cgaattcatc gtcaagctca ggaagctctt tcgctttgat 2393281 ttcgtgaatt ttcactttaa acacagctgg tttgcctgca agatcttcag cgtggtactc 2393341 ctcagggaat gtcacttcaa catccttctc agcacctgct tcaaggccaa ctaattgatc 2393401 ttcgaagcca gggatgaatg aaccagaacc tacttctaga gagtagtttt cagcttttcc 2393461 gccttcgaaa gcttcgccgt caacgaatcc ttcgaaatca agaacaactg tgtttccttc 2393521 ttcaacggcg ccttcttctt ttacaacaag ctcagcttga cgctcttgaa gggcttttag 2393581 ttcgttttga acatcttcgt cagttacagt tgtgtcgtct ttttcaatgc ccaggccttt 2393641 gtattcgcca agcttcactt caggttttac tgttactttc gcagtgaaga ttaagctttc 2393701 gcctttttcg attttttcaa catcgatttc aggacggtct acaggctcga ttccagcttc 2393761 ttcaaccgct ttagggtatt ctacaggaag aagaatatcc aaagcatctt ggtaaagagc 2393821 ttctacgcca aagcgctgtt cgaataatcc gcgaggaatt ttacctttac ggaatccagg 2393881 aattgaaact tgttttacta cttttttaaa tgcatcatca agtgctgttt taaacgtttc 2393941 agcatcaact tcaaccgtta aaacgccttc gttgccttct tgtttttccc attttacaga 2394001 catgtgtttc cctccaaaaa tctattcagg ttgtgtcggt cttccattct aaagcaatca 2394061 ttcggcttcg tccaacaaaa acaaagctgc caaagatcag aatcattatg tatagatgtt 2394121 aataatgaac tgcaaagcct gtccaaccgt atttcttata acccgttata cacaaataca 2394181 accactatat tataacataa cacatagcgc tttcaactat atggcgcgat ttacaaataa 2394241 gaaatttctt caatatcttt taacattgtg caagcttcat cgagttctct gtctgtaaat 2394301 tcatacatca tatgaagttc ttcgctttca atttcaatcc cgtgcatctc gtaaccgact 2394361 ttatgaaggg cagccgccca aaggtcagcc gacagcaatt tcggctggaa cggatataaa 2394421 acgtacaaat gtcttctcca caattcttct actgctgcat ataaggttgg attttcattt 2394481 ccaagtgtct catctagcac cctgagaaca cggtgaagaa tcggcgcggc atcaggcgga 2394541 acaatctctg acggttcaat tgtcaacgac tcgccaaatt tactaatgtg tacaggttta 2394601 ctgtactcat gctcagccaa cagcatgaca atcatcgttt tgataatcgg atgggctgag 2394661 gggtcttgga ggattgtttt gagcaatcct gtatactttg ctacgttacg gtcttttaag 2394721 gaatgaatga gattcatttg ctcctcaggg cttgccagca ctttctcggt gtcaattgta 2394781 tcctcatatt cttcggccca agcctcgtcc tcacgatccg gatcggtcat tttccggctg 2394841 aaatccagca gcttataaaa ttgctcggca ctttctgccg gcagctgatt ttcttccaaa 2394901 acggcttcaa tggtgctttt gacttcttcg tactttttga gctgaattaa gatggtcatg 2394961 tacacctgca aaaccgtaaa ataatggcca taaccttctt tgagcatctt ctcgcacacg 2395021 ctttctgcct cttccagctc gcccagctct aaaaagcaga tggccatccc taagtgaaga 2395081 tcggattcag tatcatcata tttcatcgct tctgaaaaca gttcaagcgc ttcttgatac 2395141 tttttttcct tgagtgatga catccctttt tccacaaggc ggtctttcag atgaggaaaa 2395201 ggaataattt ttgcgttttt cttgtcatgc gtcataccta tattcctttc aggcatttat 2395261 tttgttcaag tgtatcaaca cctgtgaaca aaaacaagaa atgaaaggtt tcaccaggca 2395321 aaaaaagccg ccggacaaat accggccgct ttttcaggct tgaagccaag agcttctttg 2395381 tgattcaaat tgcttgattt catcttccag cagcagcgtt aatgaaattt catcatatcc 2395441 gttgatcagc atctctttcc aatgcggatc aacttcaaat gaaatttgat tgccttcact 2395501 gtcatgaatc agctgatttt caaggtcaac agtcatttgc aatgactggt tttcatactg 2395561 gccgacaagc tgtttccaat tgtcatatgg catgcggatc ggaagcatgc cgtttttaaa 2395621 gcagttctga tggaaaatat cagcgaatga cggcgcaatg ataattttaa acccataatc 2395681 atcaagtgcc cacggagcgt gttcacgcga tgacccgcag ccgaagtttt ctcctgctat 2395741 taaaatggaa gctccttgat aaacaggctg gtttaattca aattcagggt tcggttcacc 2395801 attcgcatca tatctccagt caaagaatgc aaaacgtccg tagcctgttc tttcaatcct 2395861 cttcaaaaat tgcttaggaa taatctggtc tgtatccaca ttgatccgat ttaatacggc 2395921 tgctttcccc gtatgtgatt tcaaaggttc catctcgcgc actccttaca caactgtttt 2395981 ttcctgataa aactttctga catcaacgaa gtgtccgtga atggcagcca tcgcagccat 2396041 tgccgggctg acgagatgtg ttcttgcacc ttttccttgt ctgccctcga agttgcggtt 2396101 agaggttgat gcacagcgct ctccctcagg aacaacatca ttattcatac tcaaacacat 2396161 gctgcagcct gactctctcc attcaaatcc agcttccaag aaaatctggt caagcccttc 2396221 tttttcagcc tgaagcttca cgctttggga tccgggcacg acgatggccc ttacgctgtc 2396281 agctaccttc ttccctttga tcatgtcagc agcctgtcga aggtcagtca tgcgggaatt 2396341 tgtgcaggaa ccgataaata cgtgctccac tttaatgtct tcaatttttt ggtgaggagt 2396401 caatcccata tattcataag cacgaatcgc ttctttttta tcgtcttctg cagaaaagct 2396461 ttccggcgca ggaacttcag aatcgacagg aagaaccatt cccgggttaa tgccccatgt 2396521 caccataggg gaaattttgt tgccgtcaag gacgatagat ttatcgtaaa cagcgcccgg 2396581 gtctgtgcgc agcgccttcc attcctctac ggccttgtca aattcttcgc cttttggcgt 2396641 gtacttgcga tttttgcaat attcaaacgt cacctcgtca ggtgcaatca aacctgctct 2396701 tgctcctgct tcaattgaca tgttacaaac agtcattcgt tcatccatcg tcatatttct 2396761 gaatacttcc ccagtgtatt caatgacgta gcctgtgccg aatttcacac cgtatttgcc 2396821 gatgacagca aggatgacat cctttgccgt tacccctttt tgaagcgttc catctacgcg 2396881 cacttcaagt gtttttggac gctgctgcca aagtgtctgt gtggaaagga catgttcaac 2396941 ttcactcgtc ccgattccaa atgcaagagc gccgaaagcg ccatgtgttg atgtatgact 2397001 gtcaccgcac acaatcgttt tccctggaag cgttaagcct agttcaggtc cgacgacatg 2397061 gacaatccct tgatccacac tgtgaagatc ggcaaggcgc acgccaaatt cctcacagtt 2397121 tctttcaagc gccgttacct ggcgtttcgc aacttcatcc tttatctcaa aacgattgac 2397181 agtcgggatg ttgtggtcca ttgtcgcaaa tgtgttttgg ggtcttctga cctttcttcc 2397241 cttttgtctc aagccttcaa atgcctgagg agacgtcacc tcatgaatga ggtgcaaatc 2397301 aatatagaga agatccggct ttccctcacc atgttttaca atatgctgat cccaaatctt 2397361 ttcgatgatt gttcgaggca tcatctttta tttcctccct ctacctagag ctaagaccgc 2397421 ttaacgtaag ctgtcacaca ttagaaattg tattttcact catgattgct gccttaactt 2397481 cctctgtaat ggcctgagtg ctgctgaact cttcactccg tgccaagtct cttgttcttt 2397541 ttccagaagc caagactttg tttaccgcat cttctacagc tttcgcttcc tcttcaagcc 2397601 cgaaagatgt tctcaaaagc attgccgctg acaatatggc tgcgaacgga tttgccatcc 2397661 ctttaccggc aatatcaggc gcggagccat gaacaggttc aaacagatga aggccagagc 2397721 ttgataggct ggctgacggg agcattccga gcgagcctgt aagcatggac gcttcatcgc 2397781 ttaaaatatc accgaacata ttttcagtca ccacgacatc aaattgattc ggtgcataaa 2397841 ttagctgcat ggccgcgtta tccacaagca tgtgctcaag cttcacatca ggaaattctt 2397901 gtgcaacgtc ctcagccact tcacgccaca gccggcttga ttcaagaaca ttcgctttat 2397961 ctacagaggt cactttgcct tttctggctg ccgccatttt gaagccctct ctgatcactc 2398021 gttcaatttc cgttcgctta taaaacagtg tatctactgc ttcctgctca ccttcagtgt 2398081 ttacataacg tttgctcggc tggccgaaat acaagccgcc tgtgagctca cgaacgataa 2398141 cgaaatcaac attatctata tattcttttt tcaaaggcga agcgtcagaa aggctttcaa 2398201 ataccttcac aggccgcaaa ttcgcaaaca aatcaagctg ttttctgatg ctgagcagcc 2398261 ctttttccgg tctcagttcc gaaggatttt gatcccattt cggtccgccg acagcaccaa 2398321 gcaatatcgc gtctgcattt ttacaagcag caacggtttc ctccgggagg gggttatgat 2398381 gttcatcaat agccgcccct ccaatcaggc catattcaaa ttcaaattca tggttaaagc 2398441 gttcggcaac acttttcagt acgtctgtcg ctgattctaa tacttcaggg ccgatcccgt 2398501 ctccgggcaa tagagcaata cgtttcttca agttaaccgt tctcctttct tttatgatcc 2398561 gacagctgtg tggtttttca atccgctcat attcgactgg aaaaccaatt gacggtttac 2398621 tgcgttcaaa taggctttcg ctgatgcttc taatacgtct tgcgctatgc cccgccctgc 2398681 tgattctttt ccgttcacca aaactcttac atacacctgg gcaaatgcat cttcgccttt 2398741 tctattagac tgaatgcggt agtctaagag ctccacatcc ttatcgatgc agcgctcaag 2398801 cgtattgtag attgcttcca cgcttccagc tccagttgca gcttcctgaa taagctgtgc 2398861 gttttcttga tttttcaaag atagagtagc cgtagggacc tgacttgttc cgtaatgtac 2398921 ttgcagagaa agaaattcat acccaatctt gcgatctgtt actttttctt ctaaaataag 2398981 agaaacaaga tcctcatcag tgatttcttt tttcttctca gtcaactctt tgaacatcgt 2399041 aaagaattta ttaatctctt cactgtcaaa ttggaatcct aaagcagtca gccggtcttt 2399101 aaatgcgtgg cgtccggaat gtttacctag gacaagcgca tctgcggtta cgccgacaag 2399161 ctccggtgaa ataatttcat aagtcgattt ttcctttaaa aagccgtcct gatggatgcc 2399221 tgattcatga gcaaatgcat tatctccaac aaccgctttg ttgcgcggga cagccatgcc 2399281 tgtcagtttg cttactaaat cacttgttct cttaatctcg ttcagcgtaa tacctgtttc 2399341 gacttggtag aaatcttttc tggtatggag ggctacggca atttcctcta atgccgcgtt 2399401 tccggctctt tcaccgatcc cgttcacagc gcattcgatt tgatcagcgc cattttcaat 2399461 cgcagcaaga gagtttgcga ctgccattcc caaatcatca tgacagtggg ctgaaagctt 2399521 tgctttgtga atgttcggaa cgttttcttt catatattta aagatatttc cgtattccgc 2399581 cggggccagg tagccgacag tgtccggaag attgataaca ctggcgcctg cgtcaatcac 2399641 tttctcgacg atttctgcta gaaacggcag ttcagtgcgg caggcatctt cagctgacca 2399701 ttgcacaatc ggaaaacgtt cttttgcgta tttcaccatt ccaactgctc tttcaatgac 2399761 ttgttcacgt gtcattttca gcttgtgctt caaatgaatg tccgatgtcg cgataaatac 2399821 atgaattctt ggttgagcgc catcctttaa cgcttcccaa gcagcatcaa tatcaccttt 2399881 tacacaacgg gccagaccag ttactgaaca atttttaatg gttcttgcga tttcctgaac 2399941 agctaaaaag tcacctcggg acgaagcggg aaatcccgct tcaatgatgt ctgccccgag 2400001 tctttcgagc tgcttagcta tggcaagttt ctcctgtgta ttcaagttca ctccagggga 2400061 ctgttcacca tcacgaagcg tcgtatcgaa aaaattaatt ttgcgcaacg gagaccaccg 2400121 cttccttctt cttgccttgt ttcacaaacg gcatcatttc acgaagcttt cttcccacta 2400181 cttcgatttg atgttcgttc tcgcttgcat tgatagcgtt gaaacgagga cggtttactt 2400241 ggttttcgac gatccactct tttgcgaatg taccgttttg gatatctttt aatacttctt 2400301 tcatagattc ttttactttg gcgtccacaa cgcgagggcc tgatacgaaa tctccccact 2400361 gtgctgtgtc agagattgaa tatctcattc ctgcaagtcc ttcttcgtac ataaggtcta 2400421 cgattaattt cagctcatga agacactcga agtatgcaag ttcaggctga taacctgctt 2400481 cagttaaggt ttcaaatccg gctttgacaa gcgcgcttaa tccgccgcaa agaactgctt 2400541 gctcaccgaa caaatctgtt tctgtttctt ctttaaatgt cgtttctaat acgcccgctc 2400601 ttgcgccgcc gattccttta gcataagcga gggctttgtc tcttgcttct ccagtcacat 2400661 cttgatagat tgcgaacaat gcaggtacgc cagctccttg ctcatatgtt cttcttacca 2400721 agtgtcccgg gcctttaggg gccactaaga atacatctac atccgccgga ggaacaattt 2400781 gatggaaatg cacgttaaat ccatgagcga atactaatga ttttcctgct gtcaattcat 2400841 ctttgatttc agcttcgtat actttttgct gctgctcatc cggaagcaga accatgatga 2400901 tttcggcttg ggctgccgct tcttttactg aaaatacttt atgtccgtct tcttgggctt 2400961 gagtgaaaga ttttccttgt ctaacaccga cgatcacgtc tactccgctt tctttaaggt 2401021 tcagggcatg tgcgtggcct tgcgaaccgt acccgataac cgctactgtt tttccagcca 2401081 atacgttctc tttgatatca ccgttataat atacttttac catttcaatc tctcccttgt 2401141 tatgttttat acaatagata ttgttttatt ggatgacgcc ttttgctggg ttcccctcgc 2401201 aaaagccgtt gtacctgttc tcgcgatttc tttaatgcca taaggtttta ataactcaat 2401261 aagcgcttca attttgttag attcacctgt cacctgaaca acgatgctgt ctctgctgac 2401321 atcaacgaca gaggctctaa acggttctat gattccatta atctctgttc ttgttgaagg 2401381 tgcggagaca accttgatta aggccagctc cctctggaca atcgattgat ttgtgatgtc 2401441 tgtgactttc agcacatcaa tctgtttgtt gagctgtttc gttaactgtt caacatcatt 2401501 ttcaccttca acatgaacga cgaaggtgat tctggaaacg ccggctgttt ctgtgtgtcc 2401561 aactgtaatg ctttcaatgt tgtaatgcct ttttgtgaat agaccggtga tccggtttaa 2401621 caccccggag cggttcacca cagtcaatgt gataattctt ttcaaggttt cacccccacc 2401681 atttcatgca gccctttccc cggagccacc atcgggaata ctttttcttc gctggcaacc 2401741 cgcacgtcaa tgacaacagg ttctcttgat gttaatgcct cttccagctt ttcctttgct 2401801 tccgcttctg atgaaattct gatgccttta atgccgtatg cttcggacaa tttgacgaag 2401861 tcaggctgag aagcgaattt agattctgaa taacgttctt catagaaaat ttcctgccac 2401921 tgtctgacca ttccgagaca agcgttattt aaaatcacta ccttgaccgg aagatttaat 2401981 tcgcgaataa catcgagttc ttgaagcgtc atttggaatc cgccgtctcc gacaaccgcg 2402041 acaacagtag catctttttc ggccagctgt gcgccgatcg ccgccggaag accgaatccc 2402101 atcgttccaa gtccgcctga cgtgacccat ttatctgctt tttggaacgg ataaaattgc 2402161 gctgaccaca tttgatgctg gcctacatcc gttgcgacaa tggcctctcc ttttgtaaat 2402221 tgatgaatat attcaatcaa tttctgaggt ttaaaacctt cttcttcatt atctacatac 2402281 cagagcggat actcttcttt ccattctgcg agctgttttt tccattcgct tgaatcgctt 2402341 tgtttgccgt cttgtttgat cagctcctgc aggacaattt tgctgtctcc gactacagga 2402401 atctgtgttt tcatgatttt tccgatttca gctggatcaa tatcgatgtg ggctatcttt 2402461 gcgtttctgg caaagtgttt caggtttcct gtgacacggt catcaaaacg ggcgccgata 2402521 ctgattaata gatcacattc atgaagggcc atattggctg tataagtacc gtgcattccc 2402581 gccatcccta ggaaaagcgg atggtcagcc gggaagcctc cgagccccaa aagggtgtgt 2402641 gccacaggga tttgctgctg ttcagcataa ttttttaatt cttctgacgc ttttccgtgc 2402701 agtacgcccg cacccgccag gatcaccggt tttttcgcac tgctcacggc ttccacaagc 2402761 ttgcggatct gcaaataatt cggctctgtt gtcggctggt atcccgggag attcatctca 2402821 tgatcgtagc tgaattctcc ttcaattgtt gctacatctt tcggaatatc aatcaataca 2402881 ggtccgggtc ttccagttgt tgcaatatgg aacgcttctt taatgatgcg cggcagatct 2402941 tccggctggc gaacctggta gctgtgtttt gttactggca tcgtaatccc taaaatgtct 2403001 gcttcctgaa atgcatcgct cccgattaca gaggttgcta cctgccctgt aaagacgact 2403061 aacggcaatg aatcaatcat ggcatcagca aggcctgtaa caaggtttgt cgctcccggc 2403121 cctgacgtgg caatgacgac acccggtttt ccggagaccc ttgcgtatcc ctccgctgca 2403181 tgaattgctc cttgttcgtg acggggaagg atatgtacca accctgaatt gtatagctta 2403241 tcgtaaatcg gaagcacagc cccgcccgga taaccgaaga tcatttctac tttctctttt 2403301 tttaatgatt caatcagcat taatgctccg ctcatcgtct gtgtacattc ggcagatgct 2403361 gaatccacct gtacattagt ccccatttta gttcctcctt ttggattttc atcctttaaa 2403421 gatcatcttt tcattagcta gatagctgat tattcaataa aaaaagccct tccgcccaca 2403481 atcagccgcg cagtaactgc gatagctaaa aggggcgaaa aggcttttct ttccgcggta 2403541 ccacccttgt ttacggcctg ttaatcggcc gtctcatgga tatttctatc cgctttagta 2403601 acgagtgaat caagttcacc cggccaagtc ctactgtcat ttcagactgg cactctgagg 2403661 cgagttcacc ttgtaaagct tcgccggttc tcagctaacc cggttctctg tggaaaactt 2403721 tatcaaggct acttatcctc atctgcgctt ttcatattca gccttcggaa cggctttcca 2403781 gctgttcaag aaggtcgttt gtttttcatt tttttagaat catactgcga tgattttcgc 2403841 ttgtgaagct tgcatttatc ttttgttgaa ctcatattac gccgctttgg acgcagtgtc 2403901 aacagcattt tttaaaatta ttagacaatt ttgattaatc aatctatatt gtatacgctt 2403961 tcattattgg tacaaaagga attgcaaatg ttaaaagttt ttataatttt tttattaatc 2404021 tatcaagaat acaccagaat tatttaattt tatataaaca tggaagattt tataacacga 2404081 tatggttcgt atatggattg agtctgacag atcatcttgc aatccatttc aatttcggat 2404141 aggcacttct cttgttccct cggcatacat taatgatatc ttgcaaagaa aaggtgatac 2404201 gatgaataaa tcatttgcag acatgcaagg atttcctgcg ggctttccaa gcttccccaa 2404261 ctttccgcag cagtactatc ctgctgtccc tcccttttac cagcaaagcc agcagccatt 2404321 tggaggctac ggatacggac agccgttcag tcaggcatac agcccgttaa ccactccctc 2404381 tggaatgtac tcctcattcc catacgcttc aggattttac ggacagcaat tttcaggtgc 2404441 aggctttagc ggccatggcg gcagcttaag tgctccagcg atacatgccg gcggattcag 2404501 cggggcgcca ggcgtacacg gaggctttag atattaaaga ataccacaag ggccgaacat 2404561 ctattgcggt ccttttattg ttttaaaacg acttcacaag tacagtcaca ttttctgtct 2404621 ttatatttgg aaacaggatg gaatatgatt aagatgaatt gaacgatatt ctgcacaatc 2404681 cgtaagtttt cgaggaggaa taaaattgca tataaaaata gacgatttaa ctggacgtca 2404741 ggtggtttca ctggtgaatg agcatttaca tagcatgacg cttatgtccc cgccagaaag 2404801 cattcatgcc ttaggtctag aaaaactaag agggcctgaa ataacatttt ggagcgcatg 2404861 ggaaggtgat gaactagctg gctgcggagc gctaaaagaa ctggacaccc ggcatggaga 2404921 aatcaaatca atgcgaacat ctgcatcaca tttaagaaaa ggcgttgcca aacaagttct 2404981 ccagcacatc attgaagaag ccgagaagcg aggctatgag cggttaagct tagaaacggg 2405041 ttcaatggct tcatttgagc cggcaagaaa attgtatgaa agcttcggtt tccagtattg 2405101 tgaaccgttt gcagactacg gtgaagatcc aaacagtgtg tttatgacga agaaattgtg 2405161 agacggcttt ataaggatag ataagtgcag gggaaggtct gtcttatcta tcttttttta 2405221 tattcacaca tttttcacct ttatgataca cgccaatgtt ttcaattttg tttaattcaa 2405281 agaacagcgg gaattacaaa cgacatgaac gatatcatgc aaattcataa aggaggagat 2405341 tgatatgaaa agcatagttg gtgtatatga aactccgcag gaaaccatcg cagcgattga 2405401 aggcttactt acaaaaggct atgattctga tgacatttct gttgtgacaa gccggcgaga 2405461 tacagattat ttggagtcac gtacaggaac agaagtcaat caagctatcg atgcacatca 2405521 ggacgaatct gaatcttttt tcgataaact gaaagattat ttcacaatgg atgatactgc 2405581 tacacacagc aaagcattat ccgacttgga tattaaaact gatgaaatag acaagtatca 2405641 agaagatttg gatgacggaa aacttctggt agccgtcgat acagatgcag atgtaattgc 2405701 tcctattgat aacggcaatg ccctttcagg cggcttttca agcacaaatg aattggatta 2405761 tacaacgaaa gaagaaaaaa cgatgccgct ccgggaagaa cagctgaagg tcgataagga 2405821 agacgttcaa accggcgaag tagaaatagg aaaagaagtg aaaacagaaa aaagagatat 2405881 ggacattccg gtgagacatg atgaaattta tgtcgaacgc cgtccagtgg atgaaaataa 2405941 aacggacgct gctcccgtca acgattcgga agagatcaga gttccaatcg ttgaggaaaa 2406001 gctggaagtg actaaaaaac cggttgtcac tgatgaagtg gttgtcggca aacgcactgt 2406061 tgaagaaaat gaacatattt ctgaaactgt gaaaaaagaa gaacctcgtc tgaataaaga 2406121 aggaaaagtt gacggcttgg atgatgatcc gttaaataac aaatgaaaat catagaccga 2406181 caacaaaaaa cctcaaatcc taaatggatt tgaggttttt cttttggtac gtcccaggag 2406241 agattcgaac tcccgaccga cggcttagaa ggccgttgct ctatccagct gagctactgg 2406301 gacacgtttt gtttttttgt ttttcgcttt aactatcagc gacaagattt attatatatg 2406361 ggatgcaata ataagtcaac ggttttttag aatttttttc atgaggaaga aaattttctt 2406421 cctcatgaca ttttcatagt gtgactcgat tttgcagatc ctcaatttca ttgcctgctt 2406481 ggtcgtaaaa acggactgtc gcagcatcat tttctaatgt cagtatagca tagctttctg 2406541 tcctgcgcac cctcggaagc cggatgctgc ctgggttaat catcagtttt ccgcgcagca 2406601 cttcgcttcc cgcgatgtgc gaatgcccga agcagataac atccgccccg agctcctctg 2406661 cacgatagta tacgtttaac aaggtctgtt ttataccgtg aaggtggccg tgtgtgacta 2406721 gtatttttct tgagccggca gtcagaagaa gctcgtcctt aaaatcgccg gcaaaatcgc 2406781 aattgccttt tacaaccgca taaggctcca atgcaggatg cctcgtctca agctcagagt 2406841 ccccgcaatg aatcatgaga tcaacttctg cctcatgccg tttcgcaatg gtttggagtt 2406901 cttcttcaag cccatggctg tcactgataa tcagcacgtt catgtacaag cttcctcctt 2406961 atgcctccaa aagcttagac agctttttaa gcgcgtcagc cctatggctg attttatttt 2407021 tttcatcact tgtcagttca gccatcgtct tatctttatc tttcacgata aaaattgggt 2407081 catagccaaa gccatattct cctctcggtt cttcagcaat atacccttca acatggcctt 2407141 cgactgtttt tgtttcctct ccgggaatac tcacggccag tgcgcagcgg aaacgggcgg 2407201 tgcgctgttc tttttcgata cctttcagct cgctgagcac tttttcgata tttgcctggt 2407261 cgtctttctg ttcccctgca tagcgggctg aataaacccc gggtctgccg ccaagattat 2407321 cgatggatag tccggagtca tccgcaatca ccattttgtt cactgctttg gcaacagctt 2407381 ccgctttcat aatggcattt tcttcaaatg tatggcctgt ttcttcaatt tcctctgtga 2407441 atccaatttc agctaaagat ttgacatcat agcctcttgg ctcaagaatt tctttgaatt 2407501 ccttcacttt tcccggatta tgtgttgcaa taattgcttc tttcatgatg atcaagcctt 2407561 tctgtcttta tttcagttct ggcagagaat cacccagcac ttctttttgc ttgtcaatca 2407621 gctcttggat tcctttttcc gcaagaccca gaagaccgtt cagatcctct ctagaaaaag 2407681 ttgcctcttc cccggttccc tgcaattcca caaaacggcc gctgcctgtc atgatgacat 2407741 tcatgtcaac ttcagcagag gaatcttctt cataatttaa atctaacaaa attccctgtt 2407801 ccttatcaat tccaacagag attgcagcaa gaaaatcagt gatcggattt gtcttgattg 2407861 ttcctgcttt gatcagcttg ccaatcgcaa tcgccatagc aagaaatgcg cctgtaatgg 2407921 aagctgttct agttcctcca tcagcttgaa tgacatcaca gtcaatccaa atcgtccgtt 2407981 caccgagctt ttccagatct acaacagctc gaagcgcgcg gccgatcagg cgttggatct 2408041 ccattgttct gccggaaatt ttccccttag aagattctct gattgttctt tggtttgttg 2408101 cccgcggcag catgctgtac tctgctgtaa tccagccttt ccctccgccc cgcaaaaacg 2408161 gcggtacgcg gtcctcaaca gacgcgttgc agattacctt tgtatttccc gctgttatta 2408221 gaacagaacc ttccggatgg ctgataaaat ccaaatcgaa tgtgattgga cgcagctcat 2408281 cgtgttgtct tccgtcatgt ctcatgtttt acctccgatt gtatgtacat aaaccatttt 2408341 tgtcccggaa ttgaataaag aaagaggcag ccggaacgct aacctctttc ttcctagtat 2408401 atcaaaaatc ccaatttaaa aactacccgt attcacttga gatggtctgg agaccggttc 2408461 tgtgagcttt tcgccttttt catttaccag ctctgatttt ccgttcactt taacagagac 2408521 gctttttaca tccggctgct ccgttaacgt cagcacaatg ctgttcagca cttctgaaga 2408581 aatcattttc gtcttctcat cggcgctgcc gaatatagat tgattgaaat ccaacgtcac 2408641 gcgcccgtct ttgattttcg gtttgctgac cagctttaca tcttcactga agtctgttaa 2408701 cagcccgctc accttgctcg gccctttagc caattcatta atggctgctg tgatgtcgtc 2408761 tttttccgaa ttgtcgattc gtttggtcac cggcacgtag tattcactgt cttcattttc 2408821 cgccaaatag tagactgtca gcggatgggt agcagtgaga tcatttacac cggctgtttc 2408881 caaattaatg ccgtctttgc ggcttaaatc atctgagatc ggcgtccctc ctacaggcat 2408941 ctccttcagt tcatgcccgt ttattctcag cttcacttta tctatcgaac taaattgcgt 2409001 cagcgtccac gtcacagatt gaacgatttt ctgttcgtct tctttcttat aatttttgaa 2409061 ctcattagag aaatcagcta tcgccgttcc atcttttttg atgtcaacgt taacggtggt 2409121 gtcagccggc aatacagctc tgaagccatt cggaagaatt tcagacacag gcccgccctg 2409181 tacgaggtat tcaagcgcct gcttagccgt gctctcactt ttaggaagag gcagcgtttg 2409241 cgcaacaaca tacccgtttt tatcaatgag ataaagctcc ctcataacag tagatgaggc 2409301 ttgatccgct tttgcggtat cgcttttttc actttctgtt tttttggctg ctgttgtatt 2409361 tgaattggca cccgcttcat cgttcacgaa tgtaacgtct tgaggcggat caatttcctc 2409421 ggctgcctta tcagattgaa acaaaccgca tccggataaa agcaaggcag aggtgagaca 2409481 agtggcacca atgactgcag gtcctttttt cagcatactt ttccctccta aggatgtttg 2409541 tactattatg tatacgagcc tctttaggaa atagaccgaa gaattccggc aaaacagaaa 2409601 aaaacccgca acataccgtt gcggggaaaa ctatctttta atcggttctt gcagtgagat 2409661 acattccaca tgcccgactt catggccaaa ccaatcgtct gcgatttttg caaactgatc 2409721 acgcgcccct gttgtcagga actgatgatc cggggcaatc ggagactggt tcagcagccc 2409781 tttataagag agaattgtgc tgacttcccg ggctgtttca tcgccggacg aaataatgtt 2409841 tacgtgctct cccatatatc tttgaatggc ttcttttaaa atagggtaat gggtgcagcc 2409901 taaaatcagc gaatcaattg atgtgtcttt taacggatac agcgaggttt taacaatctc 2409961 gtctgctgtt ttgtcgagaa acttcccgct ttccacaaaa ggcacaagca gcgggcaggc 2410021 aaggttttca accttcaaat cagggtttaa tgccaaaagc gcttcttcgt atgcattgct 2410081 cttaatcgta ttctctgtgc cgatgacacc gatatgctga ttatccgtca cttttatcgc 2410141 tgctctcgca ccaggctgga tgactccgac caccggtata ccgacgctgc gctggatgtc 2410201 atccaaagcg atcgctgttg ctgtattaca ggcgatcacg agcattttga tgtggtggtt 2410261 ttcgagtaaa taattcgtca gctcccacgt atattgaagc acctcttctt cagggcgcgg 2410321 cccgtaagga caccgtttcg tatccccgac gtagataata ttttctttag gtagctgtct 2410381 catgatttcc ttcgcaacgg ttaaaccgcc aaccccggaa tcaatgactc ctattggttg 2410441 ttccaacaaa atcgcctcat tttctcttca tttcatgctg cagtttcatc aaagattttt 2410501 cgaagatggc tatttcttca tctgtaaacg attcgaacat atcacgcaga tattcctgtc 2410561 tttttgtaat gacctcttgg ataatccgtt ctccttcagg cagcagatgt atcctgacaa 2410621 cacgtctgtc cgccgggtcc ttgacccgct caacaagctc atttttttgc atgcggtcga 2410681 ttaagtccgt tgtcgtgctg catgccagat acattttgcc cgataattca ccgattgtca 2410741 tatctcctaa ttcataaagc cattgcaagc cgacaaattg cggcggcgta atcgcatatt 2410801 ggttaaggat ttctcgtcct ttttgcttaa tgatcgcggc aatgtggcgg agtgactttt 2410861 caatatccgc aacatgctcc aaaggttttg atgtcatttg tccatccctc actcaaggat 2410921 ctcttacgca caaaagcgtt ccgtgtctat tttccttctt ttttgaagaa aatgcaagac 2410981 tcgcaggaga gaaatagagg actttagtca aacaacatca agaaataaaa tttaatttat 2411041 gacttgccta cgttttgcac agcattccaa atatggtttc gaatgttcca aacaaacagc 2411101 aataaccggc tccttccaaa agaaggaata ccggcaagga ttaaagctct agctcaccca 2411161 ttctaagaag ctcaacaacg gcttgcgaac gccctttcac acccaatttc tgcatggcat 2411221 ttgaaatatg gtttcgaacg gttttctcac tgataaatag ctcgcttgca atctcctttg 2411281 ttgtcttatc ttgaacgagc aattcgaaca cttctctttc tcttttcgtt agcagcggct 2411341 tcgattgaaa ttctttctcc ttcaagtatt gtaaccctcc ttgctaaggt gagagcgaat 2411401 cagaaacgaa tgggttttga tatagtcgag atatcatatg taagaagggc gcaggaggtg 2411461 acgtttacaa gataattagt ttatcgtgta tgaagaagcg tttctttctc ctcatccgtc 2411521 cagctgacag ccttgccgct ttcctttgag acttgaacca tcacgactgc cccggtgaag 2411581 cagggttcgc cttcgaggtt ctctccgaga tagtgcaagg taagagatga actgccgact 2411641 gcgcttgttt tcacatagat gcgcaactct tcataaggca tgacttggcg caaataatcg 2411701 cattgctggc ttgccacgac tgtcatggtc tgtttgtttt cactcatcat attcagcttt 2411761 ttaaaataag aaatccgcac ctcctcaaaa tatataaaag gggttacatt attcatatgc 2411821 ccaaacatgt ctgtctcgga aaatcttacg gataccttat tgaaaaaaga aaaggatgtt 2411881 ttccattctt gaaacggcat atcaatataa gcgggaagct tcatcttttt tcatctcctt 2411941 attgtttaaa aaaacctctc ccatgcggaa gaggtttttt cttcttatac tctgtcgctt 2412001 ccgaagaaat tgcggaacgc ttgtaagttt gtatctctat tcaaggctgc aatcgaagtg 2412061 gtaagcggaa tccccttcgg acaggattga acacagtttt gcgagttgcc gcaatctgca 2412121 aggccgcctt catccattaa tgcttctaat cgttcagatt tattcatggc gcctgtcgga 2412181 tgcgcgttaa acaggcggac ttgcgacatc ggtgcaggcc ccatgaactt cgatttgctg 2412241 ttcacattcg ggcaagcttc gaggcagacg ccgcatgtca tgcattttga taattcatat 2412301 gcccattgac gacgtttttc cggcattctc ggccccggtc ctaaatcgta cgtaccgtca 2412361 atcggtatcc acgcttttac ttttttcaat gaatcaaaca ttctgctgcg atcaacctgc 2412421 aaatcacgaa cgactgggaa tgttttcatt ggttttaaac ggattggctg ttcaagctgg 2412481 tcaataagcg ccgtacaaga ctggcggggt tttccgttta taaccattga acatgcgccg 2412541 catacttcct caagacagtt catatcccat gtgacagggg ttgtcttctc acctttgaca 2412601 ttaaccggat tccggcggat ttccatcaga gcggaaatga cgttcagatt cgggcggtat 2412661 ggaatctcaa attcttcatc ataaggcgtg ctgtcagctg tatcttgacg tgtgataata 2412721 aatcgtatgg ttttttgttc actcatgatt atttcgccac cttcttcttc gagtaatccc 2412781 gtttccgagg cgttatcagt gatacatcga catcctgata ctcaaattcc ggcgcttcat 2412841 acgggcttac atgtttagcc attgttgttt tgagccattc atcatcatta cgttcaggat 2412901 aatccggttt ataatgggcg ccccggcttt cattacggtt gtatgcgcca agggtaatca 2412961 ccctcgcaag ctgaagcatg ttcgagaact ggcgtgtgaa catcgctccc tggttgctcc 2413021 attttgtcgt gtcattgatg ttgatctttt tgaagcgctc cattaactcc tgaattttgt 2413081 catccgtttt caaaagcttg tcattatggc ggacaaccgt tacgttcgcc gtcatccact 2413141 caccgagctc tttgtgaaga acataggcat tttcggttcc gtccatactc ataatatcag 2413201 cccatttttc ttcttctttc ttaacgtgag cgtcgaataa agatgaagac atgtcttccg 2413261 ctgaagattc taagccgttt acatatttca ccgcattcgg accggccacc atgcctccgt 2413321 aaatcgcaga cagcagggag ttcgctccca agcggttgcc gccgtgcata gaataatcac 2413381 attccccagc cgcaaacagt ccagggatat ttgtcatttg atcgtaatcc acccataaac 2413441 cgcccataga ataatggacc gccgggaaga ttttcattgg aagcttacgc gggtcgtctc 2413501 ccatgaattt ctcataaatc tcaatgatgc cgccaagctt aatatcaagc tctttcggat 2413561 ctttatgaga cagatcgaga tataccatgt tttcaccgtt aataccgagc ttctggttca 2413621 cacacacatc aaatatttcg cgtgtcgcaa tatcacgcgg caccaggttt ccgtatgccg 2413681 gatatttttc ctccaggaaa taccatggtt tgccgtcttt atatgtccac acgcgcccgc 2413741 cttcaccacg cgctgattca ctcatcagtc ttagtttgtc atcgcccggt atggctgtcg 2413801 ggtggatttg aatgaattct ccgtttgcat aatacgctcc ctgctgataa acgattgacg 2413861 cagcagatcc tgtattaatc atggagttcg ttgattttcc aaagatgatt cccggtccgc 2413921 ccgtcgccat aatgacagcg tctgaacgga aggattcaat ttgcatgttt gtcaggtttt 2413981 gtgcaacaat tccgcggcag gttctgtcat catctaaaac agcgccaagg aattcccagc 2414041 cttcgtattt tgtgaccaga cccgcaactt cgtatctgcg cacttgctcg tccagtgcgt 2414101 aaagcagctg ctgtcccgtc gtcgcaccag cataagcagt tctgtggtgc tgtgtacccc 2414161 cgaatcggcg gaaatcaagc aggccttcag gcgtccggtt aaacatgacg cccatccggt 2414221 ctaataagtg gatgatcgaa ggcgccgctt cacacatcgc cttgaccggc ggctggttgg 2414281 caagaaagtc tcccccgtat accgtgtcat caaaatgttc ccacggagag tcaccttccc 2414341 cttttgtatt gaccgctccg tttatgccgc cttgcgcaca aactgaatga gaacgtttga 2414401 caggaacgat ggaaaacaat ttaaccgcca ttcctgattc cgctgcttta attgtcgcca 2414461 tgaggccggc aagacccccg ccgactacga taatgcttga ttgactcatg atagcccctc 2414521 tccctctagt aatctagtac tcttaaacaa atgcaaaaat cgcttttaag cctacgtatg 2414581 acagtgcaac aaaaataatc agcgtaacgt atgtcgaaat tctttgagaa cgaggcgtta 2414641 ccgtgatgcc ccatgtaaca gcgaaagacc ataaaccgtt cgagaagtgg aaaattgttg 2414701 ataaaacacc gacaatgtaa aaaccaagca tagccggaga gctcaaaata ttcgccatca 2414761 tgtcgaaatt gacctcagca cccatttgtg cggcaatgcg ggtttcccac acgtgccagc 2414821 tgacgaaaat gagggtgatg ataccggtta cacgctgcag gacgaatagc cagtttctca 2414881 tgtagctgta ttgaccggcg ttatttttcg cagtaaacgc tatgtacaca ccataaactg 2414941 catgataaat taatggtaag aagataataa aaatttccaa ggcatacctg aaaggcaggc 2415001 tatccataaa atgagcagcg ctattgaatg cttcagcgcc ccttgcggca aactggttga 2415061 cgactaaatg ctgaataaga aagatgccga ccggtatgac gccaagcaag gaatgcaatc 2415121 ttcgaaaata aaactctctg ttcccagaca ttactttacc ccctgtttga taagtgcgaa 2415181 atgtgctaaa tctcttcccc cacttctttc aattgtaagc actttattaa gatttattga 2415241 caatttcatt ttactcctcc ctcaaaaggg cgtcaagaaa acgcgtacat aaattataat 2415301 tttccgaatt gattagttga ttgaaaaatt ttattttatc aatatatatt tcttgcttaa 2415361 tttttcataa gaattacagg atcattctgt aatcctcccc cctgtttgag ctataatata 2415421 cgcaggagag aggggagaca gatatgaagt ctaaatttga agcatctatt gacaacctaa 2415481 aagaaattga aatgaacgct tatgcctacg aactaatacg agagatcgtt ctcccagata 2415541 tgcttggcca agattactct tccatgatgt attgggcagg aaaacatctc gcccgtaagt 2415601 ttcctcttga atcatgggag gaatttccgg ccttctttga agaagcgggc tggggaaccc 2415661 tcaccaacgt aagcgctaaa aaacaggagc ttgaatttga acttgaaggg ccgatcattt 2415721 ccaaccggct taagcatcag aaagaacctt gctttcagct ggaggctggt tttatcgctg 2415781 aacaaattca attgatgaat gatcagattg ccgaatcata tgaacaagtg aaaaagagag 2415841 ccgataaagt ggttctgact gtgaaatggg atatgaaaga cccagtgtaa tcaaaaaggc 2415901 ggtgactgca tagtcccgcc tttttgattg tcattacaca gctgaagggt gttttgaaag 2415961 ctcaaatgca tcgtgaagcg actcgactgc tttcaccatg tcattttcgc ttacgactgt 2416021 tgacactttg atttcagatg tgctgaccat tttgattaaa atgttttttt gcgccagtac 2416081 agcaaacatt tcagccgcta caccgggatt tgagaccatg ccggatccaa caatagatac 2416141 tttagccaat ttgctttctg tctcgatttt ctcaaattcc agcgcgtctt tatactcttc 2416201 aagcaccgca acggtttggt ctgcatcttc tgttttgaca gagaaggaaa ttccagtctt 2416261 gtcctcggcc tgcgtttgga taatgatatc cacgtttatg tttcttttgg caagtgttgt 2416321 aaaaatagta gacaaagttg tcaggccgct agtcagcccg taaatggtta ctcttgtgat 2416381 ttgatcttca aatgcaatgc ctctgacaat taaattctgt tccatggatg attcctcctc 2416441 aattaatgtt cccgcttcgg tttctgtact tgaacgcact tctaacggca cttggtaatt 2416501 tttcgcgaac tcaactgctc tcggatgaag aacaccggcg cctaaattgg caagctcaag 2416561 catttcatcg tatgagatgc cctcaagttt tctcgctgat ttcacatagc gcggatcggt 2416621 tgtaaacacg cctggcacgt ctgtgtatat gtcacattta tcagctttta aagcggcagc 2416681 caaagcaact gctgttgtat ctgaaccgcc ccggcccaat gtcgtaattt cacaatcctc 2416741 tgtcatgcct tggaatcctg caacaatgac aatttttcct ttttcaagct ggtctgctaa 2416801 aaccgaagtg tcgatatctg taattctggc gtttccgtga atggcctccg tacggattcc 2416861 cgcctgccag ccagtataag acacagcgtc atagcctttt tcctgcaatg ccattgaaag 2416921 gagtgaaatc gtgacctgct cgcctgtcgc cagcagcata tccatttcgc gtttgctcgg 2416981 ctggtcagaa atagcttttg caaggctgac caattcgtca gtggattttc ccattgctga 2417041 aacgacgaca acgacttgat ggcctttctg tttttctgca attgcgcggt ttgccgcatt 2417101 ttgaattttt tcgactgagc cgacggaagt gcctccgaat ttttgtacaa taagacccat 2417161 gtattaccac cctttacatt ttggttcgtg cgggtgagga gaaagagcgc tttgtccaca 2417221 ataaaaaaag caatgagagg aatactctca ttgcttatca attaatcatc ataaatgatt 2417281 atgaacaacg agatagccct ccaagaaaat gatttcttga cagccttaca tttattcaat 2417341 gcacggccag caaataatac cgatggggtt ttatttgctt cggcgacgct cccctttcag 2417401 cctttttcac agaatccatc tttctccaaa ggcatactct tgaagttcgc acctctatct 2417461 tcaccatata acacgatcta actatgaaat tagttcacat tttatcagat cttatttaaa 2417521 aggacaacat tatttttgca atttgtcgta aaggagctga gccgccgctg cgggaacacc 2417581 ggcttttttg atgtcctcaa ggcttgcttc cttcattttt ttaacggaac cgaaatgctt 2417641 taacagcatt ttctttcttt tctctccgat acccgggatg tcgtccaaaa cggattgaaa 2417701 cgcgcttttt ccccggattt gcctgtgaaa actgattgca aaacggtgca cctcgtcctg 2417761 aatgcgctgc aggaggtaaa attcctggct gtttcgttcc agatacgcca cctccagcgg 2417821 atcaccgatc agtaaatttg aggttctgtg tttttcatct ttcgctaaac cggcgatcgg 2417881 gatatccaag ccgagttcat tttcaatgac atcccttgct gcgttgatct gcccttttcc 2417941 tccgtcaatg ataatcagat cgggcagcgg cagattctca cgaagcactc tcgtatagcg 2418001 tcttctgaca acctctctca tagaaccgta atcatccggc cctgtaacag ttttgatttt 2418061 atatttgcgg tattcctttt tgtatggttt gccatcgata aacacaatca tcgcggaaac 2418121 cgggtttgtc ccctgtatat ttgagttatc aaacgcttca attctgtgcg gcgtataaat 2418181 atttaatgcc tcacctagtt tctgcactgc cccgattgaa cgctcctcgt cccgttcgat 2418241 taaagagaat ttttctttca atgcgatttt cgcattttta tgggcaagca tgagcagttc 2418301 ttttttcggg ccttttttcg gctggtgaac gtttgtttcc agtagctgct cgatcataga 2418361 ttgatctatg ctgtccggaa ctaaaatctc cttcggaagg aagtggttgt tttttgaata 2418421 gaactgcccg atgaacgtga ggaactcttc atctgcttcc tgataaagcg ggaacatgct 2418481 gacatcgcgt tcaatgagct ttccttggcg gatgaaaaag acctgcacgc acatccagcc 2418541 cttatcgtac gcgtacgcga acacatcacg gtcgactaga tcgttcatcg tcattttttg 2418601 tttttccatc gttgattcaa tatgggcaat ttggtcacga agctcttttg ctcgttcaaa 2418661 ctcaagattc tcagcagctt catgcatttt ctcttcaagc tcttttttga cctcattata 2418721 gccgcccctt aagaaacgtg taatgctttc aaccagctct ctgttcgtct cttcggaaat 2418781 atcctttaca cacggagcaa ggcattggcc cagatgatag taaaggcaca ctctgtccgg 2418841 gagcttggag cattttctga gaggatacag acggtcgagc agtttttttg tttcccttgc 2418901 tgcctgtaca ttcggatacg gcccgaaata gcgccctttg tcttttttga cattgcgggt 2418961 gacaatcagc cttgggtggc gttcatgggt gagttttatg aaaggatagg ttttgtcgtc 2419021 tttgagcatg acgttgtatt tcggatcatg ctttttgatc agattcattt ctaaaataag 2419081 cgcttcaaga ttggaggacg tcacaatata ttcaaaatcc tcgatttccg tcacaagcct 2419141 ttgggttttc gcgtcgtgag aaccggtgaa gtaggagcgc actctgtttt tcagcacttt 2419201 tgctttccct acgtagatca cagtctgctg ccggtccttc atgagataac aacccggttg 2419261 atcaggaagg agggcgagtt tttctttcag ttgtttgttc atatgttacc cttccttatg 2419321 tttaatcctt tatttccagt ttaacacgaa cgtttgtttt tctctatggt tcacaattgg 2419381 cgaataaaaa aagcgatccc tcaatcggaa tcgctctggc atgtaagcag cggaaaatta 2419441 aagatgtttg tttacaagct cttgaagcgc ttcttttggt ttgaagccga ctgaagtttc 2419501 aactacttcg ccgtctttta acacaagaag agtcgggatg ctcataacgc cgtattttcc 2419561 ggcagtttct tggttttcgt ctacatcgat ttttacgatt ttcagtttgt ctcccatttc 2419621 ttgatccaat tcttcaagaa caggtgcaat cattttacaa ggtccgcacc aaggagccca 2419681 gaagtctgcc agtacgacgc cttcgcttgt ttcagctgag aaagattgat cagttgcttt 2419741 tacgatagcc attattgaat tcctccaatg tgaaatgatg atttttagta tagcatctcc 2419801 cattcgttca cgctatttta atgcttacaa attatttttt cctgatcaca gccggtttac 2419861 tcatttttat atggttgaat gggatatgct ctttttttaa aacacaaatc tgataatggc 2419921 cccgatcact acaattgccc caataatcat taaaatggta cgaagcataa gatcacatct 2419981 cctcttcact gtcatgtact ttaccatgcc ctgccggagc tgttttaaaa cctgaaaaag 2420041 agcgccggca tgaagctccg gcgctcttgc gcgattaaga atcagcacgc agcgtaagta 2420101 agacgactga cattggcggg agttttactt tcagtttgtt tttgctgagc gtgtattgtc 2420161 tgaaggattc cggtttgaca tgatgaggat cgtcaaacgt gttatgcgca ttcatttttt 2420221 ctgccgtaag aatgactccg gaatggtccg ctgccttgtg taggcccctc agctcgattt 2420281 ccgcctctgc tttgttttgg tgatcgatgt tgcaaattgt gatattgata tcgccttcag 2420341 cttgtttcga cgctgaaatg ctgatttgcg gaagcgtttc accgttccat tcatagtcgg 2420401 cagacattgt ctctgtggct aaaagagaag cgtcctggtg caccttaaac atattgaata 2420461 catggtacgt cggtgtcaaa agcatccgct ctccctcagt caaaatcatc gcttgaagaa 2420521 catttactgt ttgggcgatg ttggccattt gcacccggcg gcaatgctga tggaaaatgt 2420581 ggaaatgaga agccgccacc agtgcatcac gaatggtgtt ttgctgatat aagaaaccgg 2420641 gattcgtgcc tggctcggga tcaaaccacg tgccccattc atcaataatc agcccgaccc 2420701 gctgctccgg atcgtaccgg tccataatcg tgccgtgttt ttgaatcaat tcatcgatgt 2420761 atttggcttt tttcatcgta ataaaccatt catcttccgt gaattctgtg gctgatcctt 2420821 tgcccttcca gaaatccccc ggaatcgtgt aataatgaag actcaacccg tccatcaggc 2420881 cagcggcttt tttcataagc acgtccgtcc aattaaaatc atccacattt gcgccgcctg 2420941 caattttata aatgtcattc ccgctgtaat tgcggacata agtctgaaaa cgccggtaca 2421001 gatctgcgta gtattcggga tgcatgttgc cgccgcagcc ccagttttca ttgcccacgc 2421061 cgaaatattt cagcttccaa ggctcttctc ttccattttg ctttctccag tctgacatcg 2421121 gcgtgccttc ttcaaatgtc atatactcaa tccactccga catttcctga acggttccgc 2421181 ttccgacatt gccgcaaata tatggctcgc attcaagcag ctcgcaaagc atcataaatt 2421241 catgcgttcc gaattcattt gattcaattg taccgcccca gtgagtgttc agcattgtct 2421301 tacggtcacc gacaccgttt gcccaatggt attcgtccgc aaaacacccg cccggccacc 2421361 taaggacagg aatgtgcagc tgtttgagcg cctccagcac gtcctttcgt atcccgttga 2421421 tattggggat gtctgagtcc gttccgaccc agatcccctc ataaatccct cttcctaaat 2421481 gctcagcaaa atgaccgtat atatttttgt taatggttcc ttttgcgata tctgtttgaa 2421541 tcactgcttg atgttcagac atgcctctga tcattccttt catacggata tgaaaagcac 2421601 cacagtcaaa tatgtgatct gtcgtttgcc tgaggagtca gcatgaatgt aagcgctttt 2421661 aaagtaacca tattatatat gttcgtacat gtcaacgaca ttttctattg tttttatatt 2421721 tgtacgtatg tatttataaa tatgaaaaaa cccggacttt taaagtccgg gatttccttt 2421781 atgagtgtat attcagctgt ttgaattcct cagttaataa cgggacaact tcaaataaat 2421841 caccgacgat gccgtaatcc gctattttaa agatatcggc ttcggggtct ttattgatgg 2421901 cgacgatcac cttgctgttt gacatgccgg ccaaatgctg gatggcgccg gaaatgccgc 2421961 atgcaatgta caaatccgga gtaacgactt tcccggtctg cccgatttgg agagcataat 2422021 cgcaataatc agcgtcacat gccccgcgag aagccccgac tgcggcccct agcacctctg 2422081 caagctcctg cagcggctga aatccttcct tgcttttgac tcctcggccg cccgcaacga 2422141 taattttcgc ttcggagaga tcaacaccgt ccgccgtttt tttcacgacc tcttggataa 2422201 cagtgcggag gtcagtaaga gaaacatcaa tgctttcgat gctccccgat ctgctggtgt 2422261 ctttttctga agcttgaatg ttattggggc gaattgttgc aaagatcatc ggatcggttg 2422321 aaatgacgcg ttcaaaagct ttccccgagt aaatcggccg tgtgaacaca acattccctc 2422381 cggtaacgct tacatctata gcatcagaaa ttaagcctgt ttgcagacgg gcagcaagct 2422441 tcggtgaaag atccttgccc attgccgtat gcccgaagat gactgaatca ggattttctt 2422501 gctcgataac acctctcatg acctggctgt acccgtctgc cgtgtatgtt ttcagcttcg 2422561 ggtcctcagc ggtaagaact ttatctgctc cgtaatgaat aagctcttgt gcaatgcttt 2422621 gtacattttc accgatgaga acaccgatga cttccccatc tcctgaaatg gttcttcctg 2422681 cagctattgc ttcaaaggtg acatttcgca attccccatc gcgtatttct ccaagcacga 2422741 tcactttttt tcccattcta acatccccct gtttctttga atgtccaagt tttaaatgac 2422801 tttagcttcg ctgcggagca atgaaacaag ctcttttgcc tgttcagcag gctcaccttg 2422861 gagaagcttc ccggcttctt ttttcggcgg cagaaaacgt tcaatggttt tcagctttgg 2422921 ttcagcatcc tcttcgtcca gatcaagatc atcaagttca agctcttcaa gcggcttttt 2422981 cttagccttc ataattcccg gaagcgatgg atagcgcggc tcgtttaagc cctgctgagc 2423041 tgtgacaagc aatgggagcg tcgttttgat tttttcaaca tccccttcga cgtccctttc 2423101 tgcttctgca tcagtgccgt tgatttcgag tttggtgatc gtagtgatac acggaatgtc 2423161 cagtagctcg gcaagccgag gcgccacttg tcctgatcct ccgtcaatgg caacatttcc 2423221 gccgagaatc aaatcaaact cctgatcctt catatagtgg tataaaactt gagaaatgga 2423281 atattggtcg ggttcatcaa gatcatcttc tatgttgatt aaaacagctt ggtcacaacc 2423341 catggcaagc gccgtacgca attctttctc cgcttcttca ccgccgaccg tgacagcggt 2423401 gatcgtgccg ccatgctttt ccttcagctg gatggcttct tctatcgcgt actcatcata 2423461 tggattaatg atccattccg ctccgtcatc ctgaatcttt cctgtttcaa tgacgatttt 2423521 ttcttctgtg tcaaacgtcc gtttcatcag tacaaataga ttcatgatca tatccccttt 2423581 tattcgcctt tgaactgagg ctttcttttt tcgagaaatg cctggatgcc ttccttggcg 2423641 tcctctgact caaatgcttc cccaaatcgc tttgcttcaa gctttaagct gccttcatag 2423701 gaatacacct tgttggaata aagaagttca agcaaagatg ccagcgtttg cgggcttttc 2423761 tctgcaaact tagcggcaag tgcttttgct ttttcaatca cttctgcctc atctttcgct 2423821 ccaattgaga caagtccgag atcaagcgct tcttttccgg atatcggttc tcctgatccg 2423881 atgagctcca gtgctttggc tgtaccgaca tatctcggaa ggcgctgtgt ccccgcaaaa 2423941 cctggaatga taccgagatt aagctccggg agccccagct tagcatcttc tgccgcgatt 2424001 ctgatgtgac aggccattgc aagctccagc ccgcctccga gagcagcgcc gtgaatcgct 2424061 gcgataatcg gttttggaaa actttcgatt ctctccatta actgctggcc gcgctcagcg 2424121 agcaatgagg aatcctcatt gcctttaagc gatgtaaatt ctttaatatc agcgccggct 2424181 gagaaaaatc ttccctcgcc gtgaatgata atgcttcgta cgcctgcatc tgtctcacat 2424241 tgatcaagac aggaagacag ctcttctaat atccggcttg aaagcgcgtt tgccggcgga 2424301 ttgtgaatcg tcaagactgc cacaaattga tcaaccgcaa gtgaaattgc attcatagga 2424361 cagaactcct ttacttattg tgaattccgg ataccaataa ttctaaaacg ctgtttgaaa 2424421 gcgcaacgag atcgtacttt tggtcattca tcacccaagt tgtcacagtt tcgtcaatcg 2424481 ttccaaaaat catctgccgg gcgaggcgga catcgaggcc ttcttttatt tcgcctgatt 2424541 gtataccttc cgtcaaaatg ccatccaaaa tatttaagta gccttttaat atttcgttga 2424601 ttttttggcg cagctccaag ttggattggc ggagctcaag ctgcgtgaca atggcgagat 2424661 tatggtcacc cgctaaaagg gaaaaatgct ttgaaatcac aagcgccaat ttctctttcg 2424721 ctgttgcttt ttctttaatg tcctcttcca tccgctcaat aaattgaccc attttttctt 2424781 tgaaaagaga aattaaaata tcttctttgt ttttaaaata gagatagatg gtgccgtccg 2424841 ctaccccggc ttgtttggca attttggata cctgtgactg gtggtagccg ttttctgcaa 2424901 tgacttctac tgctgcatca ataatctgca tatactttgg ccgtttttgc ttcaatgttc 2424961 atcgttcctt cctatagaaa tgaatgacta ttcattcata atttcatgat aagaaggatt 2425021 ttcaggtttg tcaagtttat tcataggcgt tctctttttt tatttgatat gatgattttc 2425081 ggtttcttct tcaagtaaac gccttcttaa aatttttccc accgccgttt tcggcagctc 2425141 ctttctgaac tcataggctt tgggcacctt atagggagct agacgtgatc tcgcaaaagc 2425201 gtccagttct tctgtatcgg cttttgcgcc tttctttaat acgacaaatg cttttactgt 2425261 ttctcccctg taggaatcgg gaacgcctgc gacaacaatt tcctggatgg cttcatgttc 2425321 ataaagcgct tcttctacct cacgcgggta aatattgtaa ccgccggcaa tgatgatatc 2425381 cttcttcctg tcagcaatat agaaaaagcc ttcttcatcc atatagccca tgtccccggt 2425441 gaacagccag ccatctctca gcactgcggc ggtttcctct ggtttattcc agtatccttt 2425501 catgacttgc ggacctttta caatgatttc tccatgctca tacggagcgg caagctcacc 2425561 cgtctcttca gaatagatcg cagcgtccgt actcggccaa ggacagccga tactgcccgg 2425621 cttgtttttt ccccagataa agttggcgtg cgtcactggg gatgcctcag acaaaccata 2425681 gccttccaca agctttccac cagtcacctt ttcaaatttc tgctttacct ccacggggag 2425741 cgcggctgat ccgctaagac agcttttaat ggatgacaga tcataatgct gcaattcagg 2425801 gtgatgcaaa aggccaatgt aaattgtcgg tgcgccagga aagagcgtcg gtttgtgttt 2425861 gtcgatgatt ttaagtgttt cgagcggatc aaacttagga agaagaatca tttcgaagcc 2425921 tagtttaatc gaatagttca tgactgccgt cagtccgtag acatgaaaaa atggaacgat 2425981 gcccagcact ttttcagcgc cttctttcac gtcatacatc caagcggcgc acatttcagt 2426041 atttgccaaa atattttggt gcgtgagcat gacccctttt ggagctccgg ttgttcctcc 2426101 ggtatactgg aggacagcga tatcatgctc aggatcgatc ttcgggattg tcaggagttc 2426161 agttttttcc tgcttcatac aggaagcgaa cgtgtgaatg ttagctgttt tgtcaaagtc 2426221 gatatgcact ttttgttttt gcgtcagcgg gtaaagaata tttttcggaa aaggcaaata 2426281 gtcttttaca ctggttatca aaatctggtc gactattgat aacgttttca tttttattgc 2426341 cttcgggaaa agcaaatcta aggtgatgat tacacttacc tgagcatctc taagctggta 2426401 ttcaagctca tgctcggtat aaagcggatt cgtctgcacc acgatgccac cggcaaacaa 2426461 gacgccataa taagaaatca ctgtttgcgg gcaattgggc agcataacag ccactctgtc 2426521 tcctttttgc aggccattgc actgcaaaaa agctgcaagt ttaagagcat ccgtcagaat 2426581 gtcatgaaag gtgagttttt ttccataaaa cgatattgcg gttttatcag ggaatcgtgc 2426641 ggcggagtct gtcaggatgg attgcagggt tttattcggc aacggaagct catgcgggat 2426701 atcgttggga tactcggcaa gccacggctt ttgagactgc ataaaacctc ccctttcgat 2426761 tttagagatc caccttatca ttatagcaga tggacggcaa aaaaaagaaa aagaaaggta 2426821 aatctttctt tttctcataa tatgaacaga tatataagac caattaacaa aaagattccc 2426881 gctgcggcga gcagtatttt cgcaagcttt tccatctatt ctccgtcccc ttatattccg 2426941 gctgccacca caaaagaaag cccgacagaa atgacaaatg aaataaagcc gacagcccgg 2427001 ttatcatttt cgatttcctg atcaatttta aaccgcggag tcaaaaactc aaaaataaag 2427061 tagctgatca gaagcataac aaacccgtaa acgccccagc cgatcatttg cagcagcgaa 2427121 ttatgctggg agatggaatg ctgaaatacg tttgcgattc ccaaaatttt tccgccggtc 2427181 gccattgcca ccgcaagatt tcctttttga atctcttccc agtttttata agccgtcacc 2427241 agctcaaaca cagtcaaaaa gaggacgagg cagagaaccg cgacactgta atatgccgcg 2427301 atttccacaa gctcgttttc ccaaaaatca ctcatggcca tactcccttt tattttagtt 2427361 caacaaccgt aacgcctgat cctccctcac ctgcttcacc gaaacgggaa cttttgacgc 2427421 tgcggtggtt tttcagaaga tcctgtacgc cttttcttaa agcgccggtt ccttttccgt 2427481 ggatgattga cactcttgga tatccggcta acaccgcatc atccaagtat ttttcaaccc 2427541 ggctgagggc attttcatag cgttcgccgc gaagatcaag ttcaagcgat acgtgatagt 2427601 cctttccttt gaccgctgta atcatttttt ctttttttgg ctccggagct gatttgataa 2427661 actccagatc tttttctttt actttcatct ttaaaatacc gatttgaacg ttccattcat 2427721 tgccgcctgt tttttcgagc aatgttcctt tttgcccgaa agtgaggact ttcacctcgt 2427781 cgccaggctt aaagtcgcgt ttttgcgttt tcggcttttc cggtttcttg gacttttcaa 2427841 aagcaggcat agcgccttct aaccgtttct tcgcgttaat cagctcgtga tccttgaagg 2427901 atttgtgttc ttcttttatg gtgcgcaatt catgaataat gtcctcggct tctttcattg 2427961 ccgcttttac tttttcagca gcctgctgtt ctgcctcttc aagcattttg tcttttttgc 2428021 tgttaagctc gatgatttgc tgctgcagct ctttatgcag tttttccgct tcttttctga 2428081 ttgattctgt ctcagaaagc tcttcttccg cacgtttttt gctttgttcc agcgacgcaa 2428141 tcatcgtatc gacttcgtta tgctcggccg tcatttctga cttcgcctgc ccgatgatat 2428201 ggtccgggag cccgaggcgt tttgaaattt cgaaagcatt gcttcgaccc ggcacaccaa 2428261 ttaaaagttt ataggtcggt gacagcgttt cgatgtcaaa ttcaacgctg gcattcatga 2428321 cgccttctct gttatagccg tacgccttca attccggata atgcgtcgta gctaacactc 2428381 gtgcattggt gcgatgcacg tcatccaaga tgctcatggc gagggccgcc ccctcctgcg 2428441 gatctgtccc tgcaccaagt tcatcgaaaa gcacaaggct gttttcattg acctgttcta 2428501 aaatgccgac aatattcacc atatgggatg agaacgtact taaactttgc tcaatcgact 2428561 gttcatcacc gatatcagcg aatacgtgct caaatactgc cgcttctgac ccttcatctg 2428621 ccgggatatg aagacctgac tgcgccatta aggttagcag gcctaacgtt ttaagggtga 2428681 ctgttttccc cccggtgttt ggccctgtga tgacaatggt tgaaaaatcg cggccaagct 2428741 cgatgtcatt ggcaacaacc tgatcaggcg gaagcaatgg atggcgggct tttttcaaac 2428801 ggataaagcc ggtgtcgttc ataatcggtt ttgtcgcttt aaccgctttt gcatatctag 2428861 cttttgcaaa aataaagtca agcgtctgca gcacttgcaa atctagaaat agctcctctg 2428921 tatactctgc cgttttctct gtcagcacac gcaaaatccg ttcaatttct tgcttttctt 2428981 tcactttcgc ctgctgaagg gaattgttca tatctacaat cgcctgcggt tcaatgaata 2429041 gtgtcgcacc agaggatgag gtgtcgtgca caattcctcc atagctggat ctgtactcct 2429101 gtttgaccgg gatcacaaag cggtcattcc gaatcgtaac aatcgtatca gacagcattt 2429161 tcgatgcgga agaggaacgc agcatcgact ctaaccggtc tctgactctt gattcgagtg 2429221 ttctgagctg tgtgcggatt cctcttaatg tttccgatgc atgatcaagc acttctccgt 2429281 gatcatcaat gcaggaatta atgtcccgct ctaaatcgga cagcgtgata agctgttcag 2429341 catgctgatg gatcagcgga atgtcgacac cgtcttcagc catttgcgtg ataaaatgtt 2429401 tcatttgttt aactgcataa agcaggcctg agatttcagt gaattcagaa ggactgagaa 2429461 cgctgccgat ttccgcccgt cttaacgctc ctctgatatc tacaaggccg ccaaatggcg 2429521 cttggcctct cagccggata atgtcagaag cttcgtctac ttcatccagc tgttttttga 2429581 tttcgtctat agaagcagaa ggcttaagct cgagaagcat ttcttttccg agcgatgaag 2429641 cggcatgccc aataacctgt tctttcactt tatgaaattc aagagctgat aatacttttt 2429701 gctgcacgat tgtgtgagcc tccttactta atcgttgcgc ttcagaaatg cctctacgtc 2429761 tttaagcgac cgggcattca gaacgttttt cgtttccgtc catcctttgc gcgcggcagt 2429821 aacgccagtt ttcatatcgt ctaacatctc aatattatgg gcatcagtat taatcaccaa 2429881 tgtaacccct tgttcgtttg ctttcattaa atgctctgtg cgcagatcaa ggcgcgcagg 2429941 gttggcattg agttcaagcg ccgtatttgt tttcctcgca agctcaatca gctgatcaat 2430001 atcgatttcg taaccggccc gtctgccgat aaggcgcccg gtcgggtgtg cgataatgtc 2430061 aacatgcttg tttgtcagtg ccgtctcaag ccgtttcata atcacgtgtt ccggctgatt 2430121 aaaactggaa tgaatcgatg caataacgat atccatttcc gcaagcacat cgtcatcata 2430181 atcgagcgta ccgtcaggca ggatatccat ctcaacgcct ttcaaaatac ggaagttttc 2430241 aaactctgca ttcagcgcgt caatttcttt tgcctgctgc ttaagtcttt ctgcagtaag 2430301 cccgttggcg acctttaaat attgtgagtg atcggtgatc gccatgtatt gatagccttt 2430361 tttgatgcag gcttcagcca tctctctgat cgaaaatgcg ccatcgctcc acgttgagtg 2430421 catgtggaga tcacctttga tttgcccgag ctctatcagt tcaatgctgt cgctgtaggt 2430481 ttccacttcc tgtccgcttt cacgaatttc cggcggaatc agcggcaggc cgaagtgcgc 2430541 ataaaattca cgttcactcg gaaatgtttt gatctctccg gtttcaactg tctcaacgcc 2430601 gtattcactg atccgctcgc cgcgttcttt ggcgatttgg cgcatcttaa tattgtgatc 2430661 ctttgatccc gtaaaatgat ggagtgttgt cggaaactgc tcttccgtca caagacggaa 2430721 atcgacgctt gtttcatatt caaaggaaag gatgacggac accttcgtat ctccgcttgc 2430781 gatcacgctt ttgatgtttg gcagctcaag aagctgctct cttacttcag ccggatgatc 2430841 tgtagcaatg atataatcca gatccttcac cgtttcccgc gctctgcgga gacttccggc 2430901 acgagaaaat ttgatgatat gcgtaaattg agaaagatgc tcctcaattt cccgcgcgat 2430961 ccggagggcg tagccgatcg ggaaccgttc aggctgtttt ccggcttccc cgagcgcctg 2431021 taatattttt tcttccgatt ttttgccgaa gcccgcaaga ccctggacct tttgctgctc 2431081 acaggcttcc ttcagagatt ctgcatcgtg tacgccgagc tctttataca gctttgcgat 2431141 ttttttgccg ccgagccccg gcagcttcaa taaaggcacg agtccttccg gcacttcttt 2431201 ctgaagcgat tcgagcgtgc ttgactttcc ttcatctata tactctttaa tgacgctgta 2431261 cgttcctttt ccaatgccgg acagcgacat catatcgtcc atttctgata agcttcggtc 2431321 gtcctgttcc agagctgccg ccgcttttcg gaaggcggat actttaaacg ggttgtcccc 2431381 tttgagttcc atatagactg caatggtttc aagcagccgg ataatatctt ttttatgcat 2431441 atcataaccc ccagacgttc acatatgttt ccatcatact tgaaaaaaac ttctccggac 2431501 aagagaagtt tttttatgcc ccgtactgtg tccacagctc ttgtaaaagc cctgacaagt 2431561 acggtgtatg gttaatgatc acatttgcga gagacgattg ccccatcatt tgctgcaacg 2431621 cgtctaccgg cagaacggat gcgacataca gcagcacaaa tgtaaataaa tagacttcta 2431681 gaaaaccgag aacggctccc agcatctggt tgatttgttt aatcaccgga atgccggcta 2431741 caatactcag gaacgagccg atgattctca gtaagatttt agcaatgata aataaaacga 2431801 taaacgcaat cgcattatag tacgctgctt ccaaattccc cgtaaaaaaa gaaagagccg 2431861 gctgtcccgc tgaaaaatcg ggtgcgggaa tccaatgtaa atgcggtgcc acgtttttat 2431921 agaataaagc cgcaaaggca attgataaaa taaagctcgt caagcggata aactgcagga 2431981 taaaaccgcg ttttaacccc agtaaagtcc ccatcaggag caagattaag atgatgatat 2432041 ctagcatagt tgttcaatcc ttttctttaa gctgacgctc cagtttttca catttctctt 2432101 gtaatttgac ataatcgtgc accacattta ccgctgtcag cactgcaagt ttatttatat 2432161 caaggtatgg atttttttca ttgatttctc tcattttatc atcaacaatt ccggcgacat 2432221 acctcatatg ggctctgctt tcttcaccga caatcgtgaa gtgctggccg taaatgtcaa 2432281 cggttgtttt tgtttttttg ccgtcagaca acgtttctcc tccattccgc gagaatccta 2432341 gttcttatca taacacgttt attaaatgaa tggaaagacg agcctcccgc tgttatgata 2432401 cactggtata tacagcgaaa agtgtaaaaa aaggagatta ttacgtgtcc cattcagtga 2432461 taaaagtatc gttgtctgct attgaccaaa tgaaaatgac gtacagcggt tcacttacag 2432521 cctctgttcc gcagggagcc gtttttcagg caaaaccgcc cggctgtacc attacagcat 2432581 atcaatcagg taaggtcttg tttcaaggaa aaaacgctgc ggcagaatcc gcgcgctggg 2432641 gaacagcaga gcctcaggaa aagaagaaaa cggccaaaaa gccggctgat ccccgctatg 2432701 cccctccggc agatatcgcc ggaatgtctg ttatcggttc tgacgaagtc ggaaccggag 2432761 attactttgg cccaatgacg gttgtatgcg cgtacgtcga caaaaccatg cttcctttaa 2432821 tgaaggaact cggtgttaag gattctaaag atttaaaaga tccgcaaatc atcgagattg 2432881 cccgaaacct gattaaaacc attccgtaca gcctgctggt gttaaagaat gaaaagtata 2432941 acagcatgca ggaaaaaggc atgagccaag ggaaaatgaa agctttgctg cacaatcagg 2433001 cgatcacaca tttattaaga aaattggatg gagtaaagcc tgaagccatt ttgattgacc 2433061 aattcgctga gccaggcgtc tacttcaatc atttaaaggg cagagacatt gtgaaggagc 2433121 ggacctattt tagcacaaaa gctgaaggta ttcacctggc tgtcgccgct gcttcaatca 2433181 ttgcaagata ttcattttta atggaaatgg ataaactatc acgcgcggca ggaatgacgc 2433241 ttccaaaagg ggccggtccg cacgtcgatg aagcggccgc caagctgatc ctcaaaaaag 2433301 gggcatctgc actcagaacc tttacaaaac tccatttcgc caatacgcaa aaagcgcagc 2433361 gccttgctga taaaaaacgt tcatagaaaa aagcttgcag atttctctgc aagctttttt 2433421 atcagcctct taaaacagct tgatatgtgt cttctaacgc tttcagcact ttgctgtgcg 2433481 cctttgtcac ttcttcttca gtcagtgttt gttcaggatt gacatactgg agtgagaaag 2433541 cgactgactt cttgccttcc tccatatgct ctccttcgta tacgtcaaat acggttacct 2433601 ctttcagaag cttgcccccg gcctctttaa tgacgctctc gagctgtccg cttgtgacgg 2433661 ttttatctgt tacaagagcg atatcacgtg tcacagacgg atattttgga atcgccgtgt 2433721 aaacaagcgg tgctgtttct gctgcgagca acgcatgaag atcgagctca aatacgtatg 2433781 tttcctttat atccagttct ttttccaatg aaggatggac ttggccgatg aagccgatca 2433841 gagaaccatt caataaaatg ttcgctgttc tgcccggatg cagctgtttg cgttcagact 2433901 gtacaaattc aatgctgtct aggacgttga gtttgtctaa cagcccttcc acaattcctt 2433961 tgacaacaaa gaaatcaact ggtttctttt caccctgcca tagctgcttg cgccataatc 2434021 cggtaacagc tcctgctacg cgttctgttt caacaggttt tgtgtcctct tccttcgtta 2434081 ggaaaacgga gccaacttcg tacagtgcaa ctgagtcagt ctgcctcgca agattgtaag 2434141 aaacagaatc aagcagattt ggaacaagac tgtgtctgag aatgcttctt tcttcactca 2434201 ttggaagcgc aagcacagta ttcagtgatt tttcaatcgc aaacgctgtc gctttcttct 2434261 cgtttgtcag tgagtaagtg atggcttgtg ataagcctgc gccttcaagg aagcgtctga 2434321 ctttacggcg ttttgcctga tatggcgtta atccgcctgt agttcccgct gtctcaggaa 2434381 gcgtagacgg aatgttatcg tagccgtaca gtcttgccgc ttcttcgatt aaatcctctt 2434441 ctattgtaat gtcaccgcgc cgtgatggga cagtcacaac gagaagatca tccgcttcac 2434501 cgaccgtaaa accgagacgt ttataaatgc tgatcagttc ttctttactg atcgtcaggc 2434561 ctagaacgct gctcactttg tcagcagata cgtgaatgtt atttgcttcg attgtcaggt 2434621 gatcttcctc aaccgttcca gcaagcacct caccgccggc atacagatgg atcagctgcg 2434681 cagcccgttc tgctgcaaga cgtacgcgtg ccggatcaat tcctttttca aatcttacgc 2434741 ttgattcact tctcaaacca aggtctttgg aagccttgcg aaccttctgc ccgttgaaat 2434801 acgcagcctc aagcaaaatg gttttcgtat cttcctgaac ctctgactct gctcctccca 2434861 tgacaccggc aacggcctgc gctttcgttc cgtttgtaat gacaaggtga tcggcagaca 2434921 gcttacgttc ttgatcatca agtgttacga tcatttcatt ctcagctgct tttcttacta 2434981 cgacttcctt agagccaaat ctgtcataat caaacgcatg aagcggctgt ccgtattcca 2435041 acaggacaaa atttgtgatg tcaacgacgt tgttgtgcgg acgaatgcct gcattcatca 2435101 gctttgtctg catccaaagc ggtgacggag caatcgtgac atttttaatg atttttgcag 2435161 tgtacagcgg gttcgcttct tgatcttcaa ttttgactga aatgtaatca gacgcttgtt 2435221 ctgaagcagc cgggtaatcc gtttgcggaa gctttacctc agtgtctaaa atcgccgcaa 2435281 cctcgtaagc aacaccaagc atgttcatgg catccgcgcg gtttggcgtt aaacccagct 2435341 caagaatcgc atcgtcaagc tgtaaagccg ctaaggcatc gcttcctgtt tcagcgtcat 2435401 tcgggaatac gaaaatgcct tctgcatact ccttcgccac aagtttgctt tcgataccaa 2435461 gctcctgtaa ggaacagatc atgccgtttg attcttcacc gcgaagcttg gcttttttga 2435521 ttttgaaatt gcccggcagc accgctccga ctgttgcaac tgcgactttt tgtcccttat 2435581 ccacattcgg cgcgccgcaa atgatttgta caggggcttc agctccgata tccacaaggc 2435641 acttattcag cttatcagca ttcgggtgct gctcgcgctc cagcacatgg ccgatgacaa 2435701 cgcctttgat gccttctcct ttgtattcaa ttccttcaac ctcaataccg gctcttgtaa 2435761 ttttttcagc aagaacagcc gggtccatgc cttttaaatc aacataatcc tctaaccatt 2435821 tataagaaac aaacatcctt gcatcctcct cttacgcctg tttaaactgc gaaataaatc 2435881 tgacatcgtt tgtatagaag tggcggatat catcaatgcc atatttcagc atcgcgatgc 2435941 gctcaacacc cattccgaat gcgaagccct gatattcctt cggatcaaag ccagccattt 2436001 taagcacgtt cgggtgaacc attccggcac cgaggatttc aatccagcct gttcctttac 2436061 atactgagca gccgttccca ccgcatttaa agcatgtcac atccacttct actgaaggct 2436121 cagtaaacgg gaagaagctt gggcggagtc tgatttcacg gtcttgcccg aacatttttt 2436181 tcgcaacaag ttcaagcgtt ccttttaaat cactcatgct gatgtttttg tcaacgacaa 2436241 gcccttcaat ttgcataaat tggtgagagt gcgtcgcatc atcgttatca cggcgatata 2436301 ctttacccgg gcaaatgatt ttaacgggac ctttgccttc atgcttttcc atcgtacgtg 2436361 tttggacagg agaagtttgc gttctcatca aagtttcctc tgtgatgtaa aagctgtcct 2436421 gcatatcgcg cgctgggtgt tctttcggaa gattgagcga ttcgaagttg tagtaatccg 2436481 tttcaacctc tggcccttcc tcgactgtgt agcccatacc gataaataaa tcttcaattt 2436541 cttcaatgac aacagtgagc ggatggcggc cgccgactgc aacagggttc cccggcagcg 2436601 tgacgtcaat tgtctgtcct gcaagcttct gtttcatttc ctcttcttca agcttctcgt 2436661 ttttgtcagc aatcgcattg gcaatacgct cccttacttc gttcgcgagc gcccccattt 2436721 ttggacgttc ctcagcagaa agcttgccca ttccgcgcag cacttctgta atcggccctt 2436781 tttttccgag atattgcacc cgaatatcat tgacaacctt caatgagctt gccgcttcta 2436841 cttgttctaa agcttcttgt tccagctgtt ttagcttttc ttccattttg catcctcctt 2436901 ttatgtaaac aaaccgtcat atgtctttgg aaaataaaaa aaacccgtcc cttgtacaag 2436961 ggacgagttg tggccgcggt accaccctta tttcagacag actgatgctg tcgtcagctt 2437021 cattgacata acggaatcag attccggttc acctttacgc gcagtgtacg cggtcccggc 2437081 gacaactcaa gaggtgaagc caatttccgg ctgcgttaaa aatgctctca gtcagcggca 2437141 ttttctccct ggaaagcagt tgatcagaaa ttgaggtcct ctgtcacggt ttttgaaata 2437201 ttatgttcta ttatagagaa atccaacgct tggcgcaaca ctatcctcgc aagtgataca 2437261 cgaggatggc agccgcaacc gcaacgttta gtgattcagc ctgtccgtaa agcggcacgt 2437321 acaggttcaa atccgttttt tccagcaatg cagcatctac ccctgcacct tcatttccta 2437381 caatgagcgc aaaggattca gactgaggaa tctcctggta aggcgctccg ttttgcagcg 2437441 ccgtgccgta tacttttacg ccctctgcct tcaattcgtc cacatatgaa ggcaggtttc 2437501 ttctcacaac aggaatatgg aagtgagatc cttgagcaga tcgcagtgtt tttccgttaa 2437561 aggcgtccgc cgtgccgtca ccgagtacaa ccgcatccaa accggccgca tcagccgttc 2437621 gaatcattgt gccaaggttt cccggatctt gaacagcgtc aatcagcagc accttgcgtg 2437681 ccgttgccag cttttcttca ggcatatggc acacagcggc aatctgctgc ggcgtttcgg 2437741 tttcagtcac agctgaaaac gcatcttcac tcagcatata gcactggata ccagtctcaa 2437801 gatctgaagg aatcctcgtt tcatccttta caaggatttc tttcacaatg cccgggcttt 2437861 tcaacgcctc ttcaacgagg tgttctccct ctatcagaaa tgtatttgtt tttgttcgtt 2437921 ctttttttgt gtgaagcttt ttccaatcct tcactttttg gttttttgcc gattctattt 2437981 gtttcactgt ctatgtggcg ctcctttttt taacatgatg ttattatatc gcaagaacag 2438041 cacataataa accaggtgca gggttagaat atacgtatta cattttagaa aaaggagcgt 2438101 tttacatgga tcttaattta cgtcatgccg tcattgccaa tgtcaccggc aataatcagg 2438161 agcagcttga gcatacaatc gtagatgcga ttcaaagcgg tgaagaaaaa atgcttccag 2438221 ggctcggcgt tttattcgaa gtcatttggc agcacgcatc cgaaagtgag aaaaacgaaa 2438281 tgctgaaaac gcttgaaggc ggattaaaac ccgccgaata agacatgaaa ccgggtgaca 2438341 gcgcccggtt tttttcttat ataataaaaa catgatgagg gggaacgcca tgtttttaca 2438401 gccgttatta gcgaaaaaaa ttattgctga agttaaaaaa atgtacgaac gtgaagtcat 2438461 tattgtaaac acggacggtc ttattatggc aggcacaaac gatgagcgtg tcggacaatt 2438521 tcatgaggga gcgcttatct gcgcaaaaga aagacgcagc gtgattatta caaaagaaga 2438581 tgaaacaagg ttaaaaggag tgaaagcagg cataaacctc cctgtatttt ttgaccatga 2438641 tgtgattgcc gtcttcgggc tgacaggtga gcctgcagag attcagccat tcggagaact 2438701 gcttcgaaaa atgacagaac tgttcattaa ggaatcgcgg cacttagagc aatcccagtg 2438761 gcgtgagaga atgctggagt cctttatgat cgattggctg caattaaagg agtggtctcc 2438821 cagttttctt gagaaagctc agcttcttgg tgttgacctt tcttcccggc gccaaatgat 2438881 tcttattcag gggtatgagt ggtcacctca tgatattgaa caaatggcac gcagctggaa 2438941 atcctcgtac cctgcggatt tgttcatcag gtggggaaat gaacggattt tgattaatca 2439001 tgaagtgccg cagcatgaac aaagggatcg gcttttgcgg aaaatccttc acatttgttc 2439061 gtttgccaat accgcaagca gccaatatac agcagctggc gccggaaggg ctgtcgcaag 2439121 ctccagcctg acagattcat acgagcaagc ggaaaaagcg ctggctgtca gccttaagcg 2439181 aaaaacgccc atatttgaag aggatctgaa gcttgatatg tgtctgacgg agatcagccc 2439241 gggaacccga aacgaatttc cgcaaagagt attaggaaag gcgctagagc atcaggaact 2439301 tatgaatacg atacggactt tctttcatca cgatttgtct ttgaaacaaa ccgctgaaga 2439361 catgcatata cacatcaata cattgcgtta tcgtctggct aaggctgaac agctgacggg 2439421 attacgtttt gaccgtaccg aggacgtcgt cacgatgtac gtcgcactct attttttaga 2439481 tcaagataca aaatagagag agtttcagtt tcattttttg tatgtttctc catggaaggc 2439541 tttgcttttt ttcttttaca atagattgaa agcgtttttt gacaggggga tgggtgaaat 2439601 gatcaccaag gatgtaaagg agcagctgat tcaggtctcc ggaccagaaa actttgatga 2439661 ctcgaatgcc ggccgtctcg tctattcata tgatgcgacg cctcagtatc agtctatgcc 2439721 tgatgccgtg attgctccga ggaatactga tgaaatatca cgcattttaa caatttgcag 2439781 cgaacatcga gtgccgatcg ttccaagagg atcagggaca aacctgtgcg gcggcacgtg 2439841 cccgactgaa ggcggacttg tgcttctctt taagcacatg aaccagattc ttgaaattga 2439901 tgaagaaaat ttaactgcca cagttcagcc gggcgtcatt acgttggata tgatccgggc 2439961 agttgaaagc aaaggtttat tttatccgcc tgacccgagt tctatgaaaa tatcaactat 2440021 cgggggcaac atcaatgaaa attccggcgg gctacgcgga ttaaaatacg gtgtcacccg 2440081 cgactatgtt attggactgg aggttgttct cgcaaatggt gacatcatcc gcaccggcgg 2440141 aaaactcgca aaggatgtgg ccggatacga tctcacacgt ctttttgtcg gctcagaagg 2440201 aacactcggc attgtgacag aggcaatcgt caaactcgtt ccaaagccgg aaacaaagaa 2440261 gacgctgctt gccctttatg aaaacatcga tgccgctgct caaacggtat cggacattat 2440321 tgccgcaaaa attatacccg ctacgcttga atttctcgat cagcctacac tattggtgat 2440381 tgaggattat gccaaaatcg gacttccgac aagcgcaaaa gcagttctgt taattgaaca 2440441 agacgggcca tttgaaactg ttgaacggga tatggaaaag attgaggcga tctgcaaaaa 2440501 aggcgacgcc gtatccgttc agaccgcaca aacagaggag gaagcgtttg ccctgactga 2440561 agcccggcgt tctgcacttt ctgccctagc ccgcctcaaa ccgacgacga ttttagagga 2440621 tgcgaccgtt cctcgctcag aaatcgccaa tatggttaaa gcgattaatg atattgctgc 2440681 taaatatgat atttccatct gcacctttgg tcatgcggga gacgggaacc ttcacccgac 2440741 atgcacgaca gacataagaa ataaggatga aatggaacgt gtcgaacagg cttttgccga 2440801 gatttttgag aaagcgattg aacttggcgg gacgataacc ggagagcacg gagtcgggga 2440861 aatgaaagcg ccttacttgg aaatgaagct gaaaaaagaa ggcattgatg cgatgaaagc 2440921 gttgaaagcg gcatttgacc cccggaacat attaaatccc ggcaaaatgt ttgcgaaaga 2440981 tgccagaaaa cgtgtggtgg cggaaagatg acaacagaaa aagaaatgaa acagatccaa 2441041 aatgaattta aagagcgtat ggatgaagga gagttattaa attgtatgcg ctgcggcttc 2441101 tgtcttcctt cctgtccgac ctatatcgaa tcgggatttc aggaaacaca ctctccgcgt 2441161 gggcgcatcg ccttaatgaa agccgtagcc gacggtatga ttgaaccgga tgaagatgtc 2441221 gaacggtcgc tgtcactttg cctcggctgc cgcgcctgtg agcctgtatg cccgtctggc 2441281 gtgaaatacg ggcagctgct tgaggaagcc agagatatta tccaccaaaa taaaaaacac 2441341 tctcttggtg aacgtgtcat gcgaaagacg gcttttcacg agctgtttcc gcatcaaaac 2441401 cgcatgcgct cagctgtaag ccttatcggt ttgtatcagc gttcaggact gcaaaccgct 2441461 gtgcgaaaat caggcatgct tcgggtcctg cctgagcatt tgcggacgat ggaagctgtt 2441521 cttcctgatg ttccaaaaag caaagacatg aaacatcggc cgcgtttcct gccttccatt 2441581 ggccccatga aaaaacgggt cgcctttttt tcgggctgct taatggatac aatgttttta 2441641 ccgaccaata acgccacatt gaagctttta cagctggcag gctgcgacat tgtcattccg 2441701 cctgaacagg cttgctgcgg ggcgcttcat ggacacagcg gtgaaaaaaa cacagggaaa 2441761 gagctcgcga aacaaaatat cgctgctttc gaagcattag acgtggatgc agtcattaca 2441821 aacgcaggag gatgcggagc ctttctcact gaatatgatc atttgctgaa ggatgaccct 2441881 gagtggtcgg aacgggctgc cgcttttgtt caaaagctga aggatttttc ttctgttttg 2441941 gttgaactcg atttccatca aatggatcta gcactcgaga cgcctcaggt cgttacctac 2442001 caagattcat gtcatctaag aaatgtgatg catacgtcac ttgagccccg ccagcttctt 2442061 aaaagcatca aaggggcgga attcaaagaa atggagaaag cagacagctg ctgcgggtca 2442121 gcgggaattt acaacatcgt cgaagttgaa atgtctatga aaatactgga cagcaaaatg 2442181 gctgccgtca aagcaaccga agcgatcctc attgtaacag caaatcctgg ctgcctgctg 2442241 cagatgaagc tcggcattga acgcgaagga ctaagcggta aagtcagagc cgttcacctg 2442301 gctgatttgc tattagaagc agccgggcac aaaacatcat gagaaagccc aaaacagaca 2442361 ttgttttggg cttttgtgcg ttattccatc ggactgcaaa tttcgatata atgtccatcc 2442421 ggatcagcga tataggcgac cgtctgcccc catggtttca ctttcggctc cccgataatc 2442481 gatacgcctt gttctctcat ccttttgatg accgcttcta cattttcagt aacaaacccg 2442541 atttcaaatg tgtttgaagc agatgtatcc ggaatgtcca gcgccgtgat gtctctggcg 2442601 ctttcccggg tattaagcgc caatatcgta gaccctgtat caaattcgac atacgtgccg 2442661 tgttcagcac gaatcggcag tcctaaaata tcccggtaaa aaatgaatag cccgcttgct 2442721 gtccgatacg tatagaataa gatatttcat tgatagattc attgccaacc cctctcagca 2442781 ttttcaatag tccttctagc ccggtataga tgcttccatc cttaagctcg gatctttcca 2442841 catctgcgcc cattttttca cagccgccac gataatgatg aagcctaaca ccagcatgat 2442901 gatagataat acgccattca atacactata tcctgctgct tcaggattga gatacacatt 2442961 gcgcaccatc caatagcccg cataattgac agtgacatat aaataggcaa gcgggataag 2443021 gcaagtcaga atgtaccggc gtttatcggc gattttcagc acgatcgtcg ctccgataat 2443081 cagccccact gaagccatca gctgattaga aacgccgaag agcgcccaaa tggaaccgat 2443141 atctcctgaa tacagcaagt acccccacat caaacaggca agcgcgctgg caaatacaga 2443201 gcccggaatc cagtctgttt tcttcagcgg cttatacacc tccccgaaga agtcctggat 2443261 caaataacgg gcgacacgtg tgccggcgtc aatcgctgtt aaaataaaga ccgcttcaaa 2443321 cataatgaca aattggaaaa agtatgaggc caaatggctg aaaaacggca ttccggtaaa 2443381 aatataagtc atccctaccg caagcgtgac ggctccccct gttcttcctt ctaagtccaa 2443441 accgatttcc ccgctcaatt caggcaaatg tacgacattc atgccaagcg tacggaaaac 2443501 ctcaggcgtg ctgttaatcg caaagtaatc agcaggctgt aaagcggtcg ctgcaatcag 2443561 cgccatgata ccgacaagac actcaacaag cattgcgcca aacgcaaccg gcttcatatc 2443621 actccattta ttcagcattt tcggtgtcgt tcctgagccg acaaaggcat ggaacccaga 2443681 gatcgccccg caggcgatgg ttattgagat gaacggccag acaggtcctg ccagcaccgg 2443741 ccctccgcct tttacgaatt ctgtaaacgc agggaacgga atggacggat tgacgacaaa 2443801 cacaccaaca atcaaagcga taaaaacacc gattttcata aagctgctta aataatcacg 2443861 cggagccaga agcagccaaa cgggaagcgc agccgcaaaa aacgcataaa caggaagcgc 2443921 gattgcaagc gttttcgtat ctagcgttaa aaagtcaccg agcgcggtag tctgtaccca 2443981 tggaccgata aagactcctg ccattaaaaa gagaaagccg accgttgaag cgagctttaa 2444041 atttcccgtt ttcttataaa ataagcccac acccatcgca atcggaatcg taatccccac 2444101 cgcaaatgtt ccccatggat tacgttcaag cgcatgcaag acaaccatcg acaggcccgc 2444161 cattgtgatc gtgatgataa acagcatgga cagtcctgta caaaatcctg caacagggcc 2444221 aagctcatcc ttcgccactt ccgacagcga ttttccgttt ttgcgcatcg atgcaaacaa 2444281 caccacaata tcatggacgg ctcccccaat taccgccccg attaacagcc acaataatcc 2444341 cggcaaatag ccaaactgcg ccgccagaat tggtccgacc agcggcccgg ccgctgcgat 2444401 cgcggcaaag tggtggccga acgaaaccca tttatttgta ggcacatagt ctttcccatc 2444461 ctcaagcgca tgagcaggtg ttggcttgtc atcattcact ttgagaacct tcaccatcat 2444521 aaatgttccg tataaacgat aggcaatagc caaaatacac attgatgcta tcacaattgt 2444581 aaccgcattc attttctccc atcccctttt ctgtttttca taaatatatc ataatttcat 2444641 ggtgaaaagc ggtcattttt tcctatacaa aaagccggct ggaatgggcc ggctcgtggc 2444701 agttgaaaga caagccggag agaaatctcc ggctttgcta ttcttatgac tgttttttca 2444761 ggcggatcac attccaggaa agcggcgtga aatgagcagt taagccgttt tcgctgacag 2444821 acgatgatcc gttggaatgc ggaacgacat tttttctgtt atgctggttt gttgctttga 2444881 tatcctgatg ctcaagtacg atgtgctctg cgatttggta ggattcaaag cctctgagcg 2444941 aaatctccgt ctccatctga tcctcagcct tgtttaccgc aaaaatagtg agtgtttctt 2445001 cctcttcaga gtacacaaca gcagcatcaa catatggcac atcagtgaaa tcagaacaat 2445061 cgtacttagg agaagaaata agcggtttca gtgactcgcc ccttccgtaa acagaagcat 2445121 gcatgtatgg atagaaaatc ggctgtctcc atgcttctcc gcctttttcc gtcatgatcg 2445181 gcgcgatgac attaacaagc tgtgcaagac acgcaatttt cacacggtct gcgtgctgca 2445241 gcatcgtaat gagcagagag ccgactaata aggcatcttc aaaattgtaa atatcctcta 2445301 aaatcggacg cgcagtgatc cacggctcga cttttttatc agcctcattt gagtggtacc 2445361 agacgttcca ttcatccaga gagagattga tagttttctt gctgcgtgtt tttgctttta 2445421 catagtcaca ggtcgcagcg actgatttga taaaatgatc caaatccata gaacgtgcca 2445481 agtagtttgg cagattgtta tcccggtttc cgtagtaagt gtgaagagag atatagtcga 2445541 catgctcata cgtatgctca agcaccttcg cttcccaatc gataaaggtc ggcataccgc 2445601 tgtttgagct gccgcaggca acgagttcaa ttgatgggtc aacccacttc atgacctttg 2445661 ctgtctctgc ggcaagccgt ccgtattcat cagctgtttt gtggccgatc tgccatggtc 2445721 catccatttc gtttcctaag caccatgttt tgatgccata cggctgttca tagccatgcg 2445781 atcttcttaa atcactccag taagagcctt tcggatggtt gcaatattca acgagattac 2445841 gggcggcatc tatgcctctt gtgccaaggt tgacggccat attgacctca gtgttcacct 2445901 tttttgccca agataaaaat tcatttgttc ccacttcatt ggtttctgtc gtttgccatg 2445961 ccaagtcaag ccgtctcggg cggttttcga ctggtccgac accgtcctcc cagttgtatc 2446021 cggataaaaa gtttccgccc ggatagcgga tgatgggaac ctgtaattct ttgatcagcg 2446081 actggacatc ttttctaaat ccatcttcat ccgcttcagg gtgatcaggc tcgtatatgc 2446141 cttcatatac cgcacgaccc atatgttcga taaacgagcc ataaatccgt ttatctactt 2446201 caccgatttt atattctttg tctacaatca ttcgcgcttt tttcatcaca cgtttcctcc 2446261 ttcattaacc tttgactccc cctaccgtca ggccggagat aaagtacttt tggaaaaaca 2446321 agaaaatgat aatcaccggc aaaatcgcaa atactgagcc ggatataagc atgtcgtaat 2446381 tatttccata agggctcagc aagctggaca gccctattgg aagcgtaaac atttctttcg 2446441 accgaagcac aatcagcggc cacaagaagt tgttccagct gtttaaggac tgaaggataa 2446501 tcatcgcacc gaaagccggt ttcatcagcg gtgccataat cctgaaaaag atgccgaatt 2446561 ccgtacagcc gtccatcctt gcagagtcca gcagatctct tggaaggcca agagcatatt 2446621 gcctgaaaaa gaaaacagca acaggtgaaa cgataaacgg caatatgaca cccgtatatg 2446681 aatcgatcaa gtgcagtccg acagtaagtt taaacagagg aagcatcatc acttccagcg 2446741 gaaccatcat aataatcagc acaagaacaa agatgatatt tctgccctta aaatcataaa 2446801 ccgcaagccc gtacccgatc atcgaagaaa aaaacagagt gagcacagtc gtaaaaagtc 2446861 cgagtacaag actgttaaaa aaccatttga aataaatgct gccgccatta aacagaaatg 2446921 tgtagttatc aaaactcatc acttttggat caatatcaag attcagcccc acacgcaaaa 2446981 gctcagatga cggctttaat gatcctaaaa gcaaacagaa aatcggaaaa agatacaata 2447041 ggctcagcat cataaaaaac agggtcagcg caattctata aacgctaaac tgaggactgt 2447101 gccgcaacat ttatccctcc cccttaaacg agcctgacag ctttaatgaa atcaggctga 2447161 caacaaggat cacaatcaaa agcacaatgc cgatggccgc tccgtatccc atttcattgt 2447221 aggcaagtcc ctgctgatac aaatatccga caagcgtcag accaatatta cccggggaat 2447281 tattctgcca aaggacgtag ctttcctcaa acatcctgaa gccgccgatg atgctgatgg 2447341 tcagcacata tacggttaca ggcttgagaa acggcagcgt gatgtgcaga aattttttca 2447401 ttgtattcgc gccgtctata tcagcggctt cgtacagctc tttcggcaca ttttgcaaac 2447461 ctgctaaaaa gtaaaggatg ttgattccca tccatctcca tgaagcaagc agcaccatca 2447521 aaaacatgcc ggtatgttca ttgttcatcc agttctgagg tgaaaagccg agtttaagta 2447581 ggatggaatt ggccagagac gtttccattt ctccgaagat cagccgaaaa atgatccccg 2447641 cgacaatggt tgaggtcaat gccgggataa ataatgctga tttaaatata tttctaaatt 2447701 tgaccagctt tgaattcagg aatatggcca gaagcaatgg aacaggaatc agcacgatca 2447761 gcgtccaaaa ggtgtattcc agcgtattcc aaagggcggt atagaacgtc gggttgttta 2447821 gcgctgtata attagacaat ccgacaaagg acacctctcc cggcaaaatt ctttggaagc 2447881 tcatgatgaa gacactaatg atggggtata gaaaaaatac gagaaaggat aaaacgaatg 2447941 gcgctgtaaa cagatagggc gccgcttttt ttgaataaaa cagatctcgc cagcctgatt 2448001 gtttcgcagc tgaaggaacg ggatgaaccg ttcccgtttt cacaggtttc atgagaacct 2448061 ccccgctttc actttttgaa tgggattcta tttctgtttc agttcacctg ccgctctgtc 2448121 caaggcttgt ttaggcgttt tttgctgaga tttaagcgcg tcgaacaata cgcttctgtt 2448181 gacaaggtct gaagccttgg caaaatcctc atgtaaataa attggattga tttcatcctt 2448241 gatatcgagc agcacagaaa aaatgcctgt tccgttttgg aagtaatccg tgtatttgtt 2448301 tttctctttc aattccttgg agctccaaac atcccagcga agcgggtcaa agccgagtac 2448361 gctccagagt tttttatttc cttcttcaga gcccttcgca aaggccaaaa actcttttgc 2448421 taactcaaca tgcttggatt gcttcggtac aacagttgcc gtaccgccca aacctgccga 2448481 gcggtcgccc ccctctttcc atgccgggag cggtctgatg gcaatcttcc ctttcagatc 2448541 aggcatataa tcgataaatc ttcccatata ccaaatcggc atgagaactg aagcagctcc 2448601 tccttggttc ataaagccgt agtattcttc actgtgatgc ccgccgcccg gcgcaggaat 2448661 catcgtttta tcattgatca tgtcttttaa atattgaagt gtttttacgt tggtgtcatt 2448721 attgaggatc agcttgccgt ttttatcaaa atagcctgag ttttgctgtg aaatcataga 2448781 taagaacgtt gcggaatcat ttgtttccac cgttcccatc ggcttcccgg tcactttgcg 2448841 cactttctgt ccggctttat ggtaatcatc ccatgtttta atatcgtcag gattgacgcc 2448901 ggcttttttc atcacatcca tgttataaaa catgaccgtt gtccctacat gtgtatcgag 2448961 tccgtaaagc tttccgtttt tgctgtacaa tgtcagccgc gcctcaacga atttatcgcg 2449021 atccttttca atcagcggag tcaagtcggc aagcggtatg tcagagccct tcaaaaagtt 2449081 tgaaaaacgg gccaattcga catctgcaat atcaggaacg ccttctcccg ctattaggga 2449141 gatagataag ttatcgtgca tttgtccata tggataaacg accgtattca gcttaatttt 2449201 gcggtcagga tattttttgt tccattcctt caccatttcc acatagaact gctcatgaag 2449261 cccgttaaat gtccaaaagg tcagctcagt ttcacccgat ttgccggatg atttttctgc 2449321 tgaacacccg gcaatgacta atgtcagcaa catcatgagc acaagaaaac agacagtcat 2449381 ttttttcatc tgcgttaccc cttccattcg aggtgcgggc tattcatata gaccatggtt 2449441 gatcagcgtt ttgttttcat tgatgattct taatccggtg catcggtctc ttaaggtgtg 2449501 cgcgtgtctg aaggcatttt tgacggaatc ctgcccgaca ccgatttcgt caaaatacgc 2449561 agggcctccg gctgatctca gccaatcagc cagcacttct cctctcggga gtgtttgata 2449621 agccgattgg atggcttccc ggcggcttgg tgaaaattcg ttcagcccgt catcctgagc 2449681 gagctttctg tatgtgtcag ttaataaaac agcggcacag cccacctttg ccccatgaag 2449741 aatctgaggc cgttttttct ccattaactc catttcaatc caatgtgaaa tatgatgctc 2449801 gccgcctgat gccggtcggg aatgatctaa tgccagcatg acaagccccg atacaagtaa 2449861 agactccatc aaaacccgta tgccagtttc cgttttcatc gcaatgtctt ctgtgtgttc 2449921 aatgcaggca gcaagcgcct cctgaacgat cttagctcct gcaggcgaat aaggctcacc 2449981 ggcaagatgc cgggatattt cccaatctgc taaagacgtg attttaccga gcatgtcacc 2450041 aaagccagcc gccaccattg actgcggtgc cgcttttaat agatccagat cagcgaacag 2450101 cgcagatggg gccttcgttt gaatggttgt tttcgtgccg tataaaataa tcggcgcacc 2450161 ggctgatgta aaaccgtcta cagatggagc agtcggataa gaaataaacg gcaaatctct 2450221 ttgaaacgcc gcaaagcgga cgatatcatg aatcgtgccc gaaccgactg cgatcatgac 2450281 atccgttggt tgtttcgtat ggatcagcac atgaatgagc gatcgttcat cagctgtcac 2450341 atctccggct tcattttctg gaatgatcag gcactcggcc tgaaatcctt cttgattcag 2450401 tcggttttct aaatcaattc ctgcaatgcg gtgtgtattc gcgtcgcaga caaggacaat 2450461 atgttgattg ttttttcgtt ttacataatc caaaagcgaa tcagctgctt gcttaccgag 2450521 aacaatttct tcaactttta taggcaacgt cttttctccg gcgttttcaa aagcacgctg 2450581 aacgtcagct gcgatacgat tcatatcaga atcccctcct cagccaattt ggttacatcc 2450641 ttaatagaat ccagcacata atccggcgtg tacaaacgct gttcaccctg tttcgcagaa 2450701 ccagttagca ctaaggcgct tttcatgcca taaagcttcc ccatcgcaat gtcagattca 2450761 atgctgtctc ctataatcat gcattcatgt gcggacagcc ccattgctgt acaggcagcc 2450821 tccgccatca gccatgacgg ttttccgaca acaagttcag tcttcgcttg tgcagaagtc 2450881 tcaattgccc cgatcattcc ggccacatca atggcatttc cgtcttcgtt cggaaaagag 2450941 cggtctttgt ttgtagcgat aatacgagcg ccgccggcag ccgcttgaaa ggcttgattt 2451001 aaatcgtcgt acgtgagcgt ttcatgaagg gagatcacga gccaatccgc ttccttcggt 2451061 tcgctcgcgt tctgcacacc ggccagcctc agctcgtcaa ccaagccttg ctccccaagc 2451121 acccatacct ttgaaaaacg ataatgtttt ttcagaaaag ccgctgtcac gcttgatgac 2451181 agaacaatgt cgtttacgtc cgtttcaatc cccgcgccaa gaagtttttt tctgcacatg 2451241 gcacgggaga tattcccccg gttgcttaaa aagacgattt tctttcccat tctcctaagc 2451301 gttttgatcg cttctcttgc tccttcgatc aactcatttc ctctgaatac agtaccgtcc 2451361 aagtcaatca gaatgccagc cggtgacaca ggcgtatcat gactggccat aatacgcatt 2451421 tgctccgtgt tttcgataaa aatgcttttc atgcaggact gtattgattg gggttacatc 2451481 cttgttcagc ataatggagt gataggccat ttcggcaacc gtttctaata caactgcgtt 2451541 atgaatggca tttaaggcgt cagtgcccca gcagaacggt ccgtgattat tcacgagcac 2451601 acccggcacc tgttcgtaat tatgatgctg aaaggtttcc gctatgactt ttcctgtatt 2451661 cagttcgtag tcatgaatga tttcttcatc gtacatttct cgagtacatg gaatcgcact 2451721 gtcaaaataa tcagcatggg tcgtgcctaa cggagggatg tctctgcccg attgcgccca 2451781 gcttgtcgcc cattgagaat gggtatggac aattcccccg atattcggaa aggctttata 2451841 tagataaaca tgggtaggtg tatctgaaga aggtttaagc gagccttcga cgacctctcc 2451901 atcaaggttc aaaacaacca agtcatcggc tgtcaggtcg ctgtattcga ctccgctagg 2451961 tttgatgaca attctttctt tttcacggtc aatgccgctg acatttcccc acgtaaaggt 2452021 taccagctga tgctcttgaa gcttcaggtt ggcagccagc acttcttttt ttaatgtttc 2452081 aagcatgctc catcaccctt tatcaattct ttttggcggc agatgaaaat tgaagatttt 2452141 tgatcgtttt cagacgcttc atgacatggt tttcttttcc gaaataatga accagctctt 2452201 tatattcagc gtacaatttt tcataaaccg cggcgttttc ggcatttggc gtataagtta 2452261 tatctttcag ttttcccatg ttcgccgctg cctttttgat atcatcgtag ccgccttttt 2452321 ctttgcctgc tgcaagcgcg ccgaaaatgg cagatcctaa ggctggggct tgcggtgaac 2452381 cagagatttt aatgtccatg tttgtcacat ccgcataaat ctgcatgaca aacgggtttt 2452441 tctcagctat tccgccggct gcgaacagtt cctcaatcgg aacaccgctt tctttgaatg 2452501 tttcgataat catccgggtt ccgtaagctg tcgcttcaac taacgctcta taaatctctt 2452561 caggcttcgt cagcagtgtc atgccaagca gcatccctgt taaatctgca tcaacaagag 2452621 ttgaacggtt tccattccac caatctaaag caagcaagcc gctttcacca ggcgcttgat 2452681 ggtttgcttt ctcactcagc agctcatgaa cgccaatgtt tttttccttt gcttcctctt 2452741 gataagctgg cgggacacat gttttcacaa accagtcaaa atgatcgccg acacaggact 2452801 gcccggcttc atatcccgca tagcccggga gaattccgtt gtccacaacg ccgcacattc 2452861 ctggaacgat atgcacctct tcaccaagta gaacatggca cgtcgaggtt cccataatca 2452921 tcagcatttt ccctggctct gtaatgccga ccgccggtac cgaaacatga gcgtccacat 2452981 tggcaaccgc aacagccgtt cccgggagaa gccctgtcag ctttgccatt ttttcagtca 2453041 gactgccggc tttttctcct actgaatgaa tagaacctga caatttgtcc tttgtaatcg 2453101 ttttcattga aggatttaat ttctcaaaga aatcatctga cggatacccc gctttttcac 2453161 tccacatcgc tttataccct gcggtacaat tgcttcgctt gagcgagccg cacagctggt 2453221 acacgatcca gtccgcagcc tcgatgatcc ggtcagccgc ttcataaatg tgaggcgctt 2453281 cctcggcaat ttgcatgacc tttggaatca tccattctga tgaaattttt cctccgtacc 2453341 gctgtaaaaa agcctctcct tcttcttccg cgatttgatt gagccgatca gcatgttttt 2453401 gggccgcatg atgcttccag agcttcacat agctgtgcgg ctcctcttca tattcaggca 2453461 gcatgcataa cggctgcccg ctgctgtcaa taggaaggat cgtacatgcc gtgaaatcaa 2453521 ttccaatccc gataatgtct ttcgggtcaa cgcccgtctg ttcgagtaaa gacggaatgg 2453581 ttgtttccaa gacttcgagg taatcagcag ggtgctgcag cgcccagtca cgcggcagct 2453641 tttgacccgt ttttggaagg acggtatcaa tgacagcatg cctgtattct tttacagcag 2453701 ccgcaagttc ctcccctgtt tggacatgaa cgagcactgc tcttcctgat aaagttccaa 2453761 aatcaacccc tattgtgtaa gccatgtgac atccccctct acttttgaag ccggtaaagc 2453821 gcctcgttcc attttaactc gtgtttcagt ttatgaattg tcgtatcacg ggaaatgaga 2453881 acactttcga ttcccgccat ttccgcccaa tcaagcattt gctccgctgt cagttcataa 2453941 gacaggcagg tatggtgtgc accgccggct aaaatccatg cctccgctgc tgttttcaat 2454001 gacggctccg gcttccagag aacacgggca accggtaaat tcggcatgtc tttttcaatt 2454061 tcctggccgt tgacttcatt cagcacaagg cggaaacgcc cgccaatatc aacaatgcta 2454121 gcttgaatgg cagaaccgct gatgccgtta aataccaaac gcgcagggtc ctctttgccg 2454181 ccaatcgaaa gcgaatgaac ctcgattttc ggctgatcca aagcgacagt cggacacact 2454241 tcaagcatgt gagagcccag aatcatttca tttcccggtt caaaatggta cgtgtaatct 2454301 tccatgaagg aagttctttt tcctttagcc atgattttca tcatccgtac aagggccgct 2454361 gtcttccaat ctccttcacc ggcaaaccca tagcctttct ccatcaggcg ctgaacggca 2454421 agtcccggca gctgtttcat tccgtgcagc acttcaaacg atgtcgtaaa cgctgtgtat 2454481 ccgccttgct caagaaaagc ggttaatcca agttcaattt tcgcctgttc tttaatggac 2454541 gctacctttg cttcgtcacg ttttgtttcc tcactgatca catatagtct gtcatactcg 2454601 gcataaagcg tgtcaacctc gtcgtccgta atgcgatcca tcacttcaac gagatccccg 2454661 atgccatatc cgtcaacctg ccagccaaat tgaatatgcg ctcccacctt gtctccgtcc 2454721 gttaccgcga catgacgcat gttatctcca aatctggcaa ccttaatatg tctgctttca 2454781 tttaatgcag ccgccgtatc catccactgg gacatttctt ttttcacttc ttcatcatcc 2454841 caatagccgg caatgacttt tcggctaagc cccattctcg agttgatgta accgtactct 2454901 cgatcgccat gcgcggattg gttgctgttc ataaaatcca tgtcaatcgt accccacggg 2454961 atatcgcgat tatattgggt atgcaaatgc ataagcggtt tttgataaga ggaaaggcct 2455021 tctatccaca tttttgcagg ggaaaatgtg tgcatccatg taatgatgcc agcacatgtc 2455081 tcactgtact ccgcttctct taacagctct ctaatggttt ccggtgaagt gacgacgggc 2455141 ttatgagtga ttttatatct ggaagaaatc ccgctgagcc cctcacaaat gcttttagca 2455201 tgctgatcta cgagttccag cgtctcttcc ccgtataggt gctggcttcc tgtcacaaac 2455261 cagaattcat aatcctttgt ctgaagcatg taaactgccc ctttctcata aaataaaacg 2455321 ctttcaaata caaaagatac gtactaatga tagaaaataa acctataaat aaatatttgt 2455381 acgaacaatt ttattatagt aattgactat tatactgtca atcttttctt ttaaaaaaag 2455441 ccgggggcag agcccggctt tttaattcaa taggacggcc agcccgagct ccaattcaaa 2455501 tcattgatga gaagctttgg aatgccgttg tcattggcat cataggcatg gcgaacaaga 2455561 atgtttccgt tcacaatatc ctggcctcca ggtcctttcc attggtcatt gcccgaatcc 2455621 aaaatggtgc ctccgccttc aagcatgctt tttccgcttt tatcaagata agggcctgta 2455681 atgcttttgg atcttccgta agcaattttg tacgtactgt ttaccccgtc acagcattta 2455741 tcaaatgaaa ccattaaata gtaatatcca ttttgatacg taagagtagg agcttctaag 2455801 gcacctccat tattcggtct agctgcaatc gaatagagcg agcctgtagg cttcattgta 2455861 ctcttatcga gcttagtcag cttaatgccg ctccaaaacg agccgaatgc aagccacggg 2455921 ttgccatcct tatcgaatgt cagctccgga tcaatggcgt tataattatt tgagcttgtc 2455981 gaacggatca ccaagccctc gtccttccag ccccccgaac tgatgcttgt tgaagatgcc 2456041 aggccaatgg cagatgtatt gcttccaaaa gaagaaacgg aataatatag ccagtacttg 2456101 ccgttatagt attggatgtc cggcgcccac tggttttggc cataattcgg cacataattg 2456161 gaccaccacg atagcggtgt agtgaaaatg gatttttgta cggtccaatt tttagcgtct 2456221 gaagacttca aaacccgcag tccccgttct tcagtaagcc ctgttccgag cgcataccat 2456281 gagctcccct ctttaatcat agtcgggtca tgaagcagct cattggatgc accccaaaac 2456341 gctgcctctg cgggagcagc agaagtgaat atcaaacctg cagccagagc tgcactcgaa 2456401 aagtgtaaga agcgtttcca tgtttttttc tttttcaatt ttgttcaacc tcctttattt 2456461 tagaaagcgc ttacaaatta gattatttat cctcccttcc tgtcaaatcg actgcgtatc 2456521 gtatatcgtc atgttcagga aattttcggt atccccttta ttgtagtcac tatgctgtaa 2456581 tttgtacaga caaaaaaata gaatccacct caataggcgg attcttccgt atctttattg 2456641 gtacgtaatt tcgtcaaccg tttttcggtc taacttctta atgacttctg taattaactt 2456701 taccgcgttt tcataatcat cacgatgcag catggccgcg tgcgtatgaa tgtagcgggt 2456761 tgcaatggta atggacagcg caggaacgcc atttgccgtc aaatggatgg cacccgaatc 2456821 agttccgccg ccggcaatgg catcaaattg gtacggaatg ccggcttcct ccgcagtggc 2456881 tacaactgca tcgcgcaaac ctttgtgaga gaccatggat gcatcgtaaa cgataatctg 2456941 cgggcctttg cccattttgc tctgcgcttc cttctcggaa atgccaggcg tgtctcctgc 2457001 tatccctaca tcaacaccaa acgcaatatc aggctgaatg gtgtgtgcag ccgttttcgc 2457061 tcccctcagc ccgacttcct cctgcacggt tccgacgcca tacactatat ttggatgatc 2457121 tgtgttttgt aagtttctta acacatcaat agcaatcgca cagccgatgc ggttgtccca 2457181 ggcctttgcg agtaggaatt tttcattgtt catgaccgta aattcaaaat gcggaacgat 2457241 catatctccc ggaagtacac cccactccaa ggcttcttcc cggcttgaag ctccaatatc 2457301 aataaacatg tcttttattt ccactgattt ttttcttgct tcaggagaca aaatatgagg 2457361 cggcttagat ccgataaccc ctgtgatttc tccttttttt gtgacaatgg tgacgcgctg 2457421 agcaagcata acctgagccc accagccgcc aacggtttga aaacggataa agcctttatc 2457481 tgtgatttgt gtcaccataa agccgacttc atccaaatgt ccggcgatca taattttcgg 2457541 gccgttttct gcaccagttt tttttgcaat taaactgccc aggcgatctg ttgtcacctc 2457601 atcagcaaat ggttctatgt atgatttcat cacttgcctt acttctcttt cattgcccgg 2457661 tatgcctttt gcatctgtta aatctttcag catggtcaat gtttcatcta attttgccat 2457721 gttccaaacc ctccttcatc agtcctgcat tcttattata caaaacatgg cgctaaccat 2457781 acgactattt cacttgaaaa tcgggtatat gtttttacag ctttctttta gaaaaagtga 2457841 aacctttttc tatgcttttc gtattacatc agatcatcac cataagggag gtgccttcac 2457901 acaatgtttg tcatggttct aaggattatt ttgcttgcac tttttgctta ttgtatttat 2457961 gccgtggtca aatatgtcgc gaatcctaag agaaggctta agctggccca atcaaaagaa 2458021 catttttata ttattgatga acaaaacaat acccggaaga attttcagct gacgtataaa 2458081 ggcgtgcttt ttgagggaga aaagcatatt ccttccaagg atcatccgct gtttattcac 2458141 acgatctttg tctggacaga atctcctgag aagctgaaac atttctctgc aaaagatttt 2458201 gagaacattg aagaaaaagt gctggaacga tatccaaatt gtaagattga ctgggaccag 2458261 cccattaaac tcgcaaaaaa agcagaagag cgttaaacgc ttttctgctt tttataaatc 2458321 aaacgggctg tagtaaatag cgatgagaat cgcttctatt accagaagaa gcggtactcc 2458381 gtacttaaaa gaagcgtgtt tcgttttatg tctgaaggtt tgcatgccaa gccagacacc 2458441 gagcgctcca aacacgatgg ctatcagcca cagccggtct tcagaaattc tccacttgtg 2458501 ctgctgcgct ttgcgtttgt caatgcccat cacccaaaaa ccgcacagat taatcaacac 2458561 caaataagca gcaataatca tgttgcctca tcctttatat agaaaaagcc gctctgctgg 2458621 agagcggctc tatatgatta cttgtttaat tgagctttag cagcatcagc aagctgattg 2458681 aatgcagtaa gatcgtttac agcaagatca gcaagcattt tacggtttac ttcgatacca 2458741 gaaagcttaa gaccgtgcat taaacggctg taagaaaggc cgttcatgcg agcagctgcg 2458801 ttgatacgag tgatccaaag tttacggaaa tcacgttttt tctgacgacg gtcacggaaa 2458861 gcatagtttc cagatttcat gacctgctgg ttagctactt tgtataatgt atgttttgaa 2458921 ccgaaataac cttttgctaa tttaagaacc tttttacgac gcttacgtgt aacagttccg 2458981 ccttttactc ttggcattga atttccctcc taattgttcc ttatccgatt acttgatgtt 2459041 agcaagcatt tgtttgatac gtttgaagtc tcctgcgctt acaacagcac tcttgcgaag 2459101 cttacgcttt tgcttttgag atttgttggc gaataagtga cttgtgtacg cgtgagaacg 2459161 ttttaacttc ccagaacctg tctttttaaa acgtttagca gatccgcggt gagttttcat 2459221 ttttggcatg ggatttcctc cttattgctt ttcgtttttc ggtgcgagca ttaagaacat 2459281 gctgcggccg tccatttttg gttttgtttc gactgtcgca acctcagcac atgcttcgga 2459341 gaaacggtct aatacacgct gaccgatttc tttatgagtg attgcgcgtc ctttaaagcg 2459401 gatagaagct ttcactttat cgcctttttc aaggaattta atcgcattgc gcaatttcgt 2459461 gttaaagtca tgctcatcga ttgtcggact taaccgaact tcttttaagt taatgatttt 2459521 ttgattcttg cgtgcttctt tttccttttt ctgctgctca aatcggaact taccgtagtc 2459581 catgattcgg cagacaggcg gttttgcatt cgctgcaact aacacaaggt caagatttgc 2459641 gcggccggcg atttcaagtg cttcctgacg ggacttgatt ccaagctggt cgccattttg 2459701 tccgattaaa cggacctcac gtgcacggat accctcatta accaattgat ctttgctaat 2459761 aatgagccac ctccatagtt tcttcgaatt gattcacaac tcattttgaa tgcattttgc 2459821 aggcaaacaa aaagtgtggg cattataaaa cacccacact acgaacatct gtatcaataa 2459881 aaatgtacgg tcaacctgcc aactacatgc atgtgtcaat caggtgagaa gcgggtgctt 2459941 ctgcttgtga tttatattca attcaataac tattctacac aataccggat ctttagtcaa 2460001 ggacgactta tccggaacaa cttttacatt gtaacatggg ttttctatga gcgcaagaga 2460061 gaaaaagaaa atctttcatc cccacccaga atacaaagaa ccaacaattc ccccttatta 2460121 cgcaatttac aacaaaacca ccgacaggaa gaaatgtaaa acaaagttaa tctctgaccg 2460181 atataaggag cagaagggag cctgacacat gaacaaactg atacagcttg ctttattttt 2460241 cacattgatg ttaaccggtt gctcgaatag cagcacatct tccgaatcaa aagtcgaaac 2460301 cactgttaag acaacggcag catttcctca aaaggagctg gagaaagagc taaaaaaact 2460361 aaaacccgtt tcattggaca tgaagttcga gagtccactc gctaccgagt taggaaagcg 2460421 gaaggcaaaa gaggaagctg aaaagcaaag acaaatcgcc gctgagaaaa agcttgaaaa 2460481 agagcgggag gcgaaacgaa agaaacagca ggaggaaaaa gcggagagac agcgattagc 2460541 agagcagcag gctgcagaga gacagcgatt agccgaagcg gaaagacaag ctgaacttga 2460601 aagacagcgg caggcagcaa tccaaaaaga gcagaaagcg aacgctgaga aaaagcggca 2460661 atcgcaggca caacggcagc agactgaggc accctcatct aatagtcaag atccaccatc 2460721 ttcctcgagt cagacagata aaaccattca acagccagct tcagagcttc ctgatgacga 2460781 tggttatggt tatgaagaac gaaaaaagtg gcatgacgat caagtagaat ggggcattaa 2460841 acaagggtat atcgatcccg aagacgcacc ataaaataaa aaaagccaag gcattcagcc 2460901 ttggcttatc ctccgatcag ctgcacgaac acagggatga ccagaaccgt taccactcct 2460961 actacgacaa cagcaatact tgccatcgca gcttcaactt ctcccatctc aatcccgacc 2461021 gctacaccaa gtgcatgtcc ggatgttcca agagccaatc ctttagaaat cggatttttc 2461081 actttaaaca ccttcaagaa caatgctccg agcgcatata cgatgacagc gttaaagatg 2461141 accgcaaagg ctgtgatgtc gctgatgccc ccgatgcctt ttgataaagg aagcgcaatt 2461201 gccgttgtag ccgcctgcgg aagcatgctt ttcattacgg ccgaatcgag atgaatgcct 2461261 ttagcgagca gataaacaat cgtgacagag cagatagagc cggcaataat ggaggccatg 2461321 atttgccacc agtacttttt aagcttatct ctttgtttgt acaaaggaat tgcaaatgcg 2461381 atcgttgccg gttcaagaaa aaacttaatg atctctcccc cgttattata atccgcgtag 2461441 gaaaaaccgc cgatttttaa aaatgcgatc cccagcacca tggcaacaaa caaaggagtg 2461501 aaaaggaaga agcctttcgt tttcttaaat aaaaaggtgc cgatgccgaa tgcagcaagt 2461561 gatacgacaa tcccaaaata aggactcatt gtgctttcca tgtgaagaac ctcctgtttc 2461621 ccttaatggt gaacgagttc gttattgttc tgcgggcttt gcactgtttt tgttttcatg 2461681 tccgcttcgg ttttgcgttt tccgctcagc gacagaatca gctgagaaaa caatcccgta 2461741 gcccccagca aaataatcgt tgcgagcaga atgacaagaa caatttgcag gccgtattgc 2461801 tgcatcacac caagcgaatt cataacagat atacctgatg gaacaaataa aaatccgatc 2461861 agagaggtta aagacgttcc gagcgtctcc acttgttcca gtttaatgac tttcaaacat 2461921 aataggagaa ataataagac caaccctaca accgatgccg ggataggtat tgggacaata 2461981 gcggcaatca tatttgaaac cagcataatg acggcaaaaa taaatgcttg tgttaaaaac 2462041 ccgtacactt ttttagcact cattttcttc acctctttct ctttggtacc ctcattataa 2462101 ataagaattc cctgttataa agcgcttaca agataacatg ccgtatagcg ggtctgagtt 2462161 gcagaatcaa atggctgaaa tgcaaaaagc cgcccatcaa atatggagca gctttttcaa 2462221 ttccttcgca tatgtccggc tgaccggtat tttcgatccg tctttcatga tcagattata 2462281 cgttgaatta aaccatggct gaatttcttt aatatattca gtattcacga caaagctccg 2462341 atggacgcgg ataaaatcag aatccggcag ctttttctca atcacaacga gtgtatcgct 2462401 gaccgtataa gaatgatcga aggtttttac attgacatga ccatcttctg ttccggcata 2462461 gataatgtcc ttcgtatcca caatcacaat cgattccccc acagatagcg cgagcttgtg 2462521 ctggccggca tggctgtttt gctctgtttc tacaatatcc cgattgactt ttttatattt 2462581 tttcagcgtt tgctgaattc tttcttcatc gaaaggcttg gttaaataat caagagcgtc 2462641 cacctcaaac gctttgagcg catactggtc atacgctgtc gcaaacacaa tagcaggagg 2462701 atgcttcatt ttcttcaatc gctttgcgat atcaaaaccg ttttctccgg ataaatcaac 2462761 gtctaaaaac agcaaatcag gtttttgatc catcatttgg tcaaaagcgg attcgatatt 2462821 ttccgcttca ttgatttcca tttcatcatt ggtccgctta agcaagtaag ccagttcatc 2462881 ccttgccagc atctcatcat caactattaa caccctgagc atgttcttct ccctctttca 2462941 tctgttgcat tggcacttga aaggaaacct ctgtcccttt atgaacctca ctgctgatat 2463001 gcagtgcagc ctgctgtccg aataaaccga tcagccgctg atttaggtta taaagcgctg 2463061 taccggttcc ctccttagac ggaaacggtt tcttccccag ttccggcaag acgtccggcg 2463121 gaattccgcg tccgttatcc gccaccttca tatagacgga tgcatcatca gataagacac 2463181 agactgtaac cttgcatatg tcttgttttt tcggaaacgc gtgccgaagc gcgttctcga 2463241 caagcacctg caaaacaaac ggagggattt caatctgctc cagtctgctg tcgatattaa 2463301 gctcaatttt atatttcccg ggaaaacgcg cctgttctaa tgacaaatag gcgttaagat 2463361 ggttcagctc ctttgagagc ggaatcagca gctgtctcgc tccttgaagg tttgaacgaa 2463421 aataaacact gagctgcaat aggagcttac gggttttttc aacatctgta cggcataacg 2463481 cagaaatcgt gttgatcgca ttaaataaaa aatgcggatt cacctgtgct tgaagcgctt 2463541 taatttcagc atccttgaga agtttgcttt gcagctctgc ttccccaagc tcaagctgtg 2463601 tcgaaaacag catggccagc ccctcggcaa gttcctcctc tacctgactc aggcctgccg 2463661 ggcttttaaa gtacattttt aaggtgccga ttgtattgcc gttcgatgtc agcggtagga 2463721 caattgcagc gtgcaaaggg cattcagcat gcgtgcattc aatctcttcc tgcgaaatcg 2463781 ccttcataat atgccctgtt ttaatcacct ttttggacag gccggtgatc aagcttttcg 2463841 atgggatgtg gtgatccatt cccgcaccga catgcgcaag gatcttttct ttgtcagtga 2463901 gagacaccgc atctgttcct gtcagcttat ggataatagc cgctacactt ttacaggagt 2463961 tttcatttaa tccttggcgg aaaaatggaa gtgtctgatc agcaatcgta agcactcgat 2464021 gcgtttcgag agcccttgcc tgttcttcct tgcgaatgat cgcttgaata atagacagaa 2464081 aaataaaact gcctgttcca ttgatgagta tcatcggaat tccgatcatg ctgacaagct 2464141 cccaagcgtc actgaacggc tttgccatca gcaaaataat gatcatttgc agtgactcca 2464201 tgccgattcc cacaagagcg gcgatgcgcg gtgtcggcat tcgatatcgc ttcgtaaaat 2464261 acctgccgat caagcctgca agaacacccg ctaaaataga tgagacggca cagcttaagg 2464321 ccgtgctgcc accgagtgaa aaacgatgca ggcccgcaag tatgccgatc ccagccccta 2464381 caaaaggacc tccgagaagg cccccgattt ccacgcccaa aatacgggta ttcgcgatag 2464441 agcccgatgg atctatcgta aacacccagt cattgtttac aatcatattt ctttgaattt 2464501 cgatgcctgt ataattgctg atgatgctga aaagagaaaa aatagaaatt aaaatcgctt 2464561 ttcctttata gccgtcctga ttctgaagag cttgtctgaa aagtttcgta tgggcgagaa 2464621 tgaaccctaa tataacaata atccccactc tctccagcat cataatcatt aaatgaatca 2464681 ttcatgtcac ctgttctttc cgttttcatt ctagcatgtt ttcgttttgc ggctgactgt 2464741 ttttttaaaa tcgtctgaaa acatatttca caaggctttt atctattgta aaataaaaca 2464801 tgagcctttt ggcagaaaga tttgaatctg aagcagagga gaagatcatg aaagccgtat 2464861 tttttgattt agatgataca ctactttggg acgaaaaaag cgtcagaaca acatttgcag 2464921 aaacttgctt acaggcggag aaaaaatatg gccttgcccc tgaggaattc gaagcagctg 2464981 ttcgcgaagc ggcgagagaa ttgtacatgt catatgagac gtatccatat acagtgatga 2465041 tcggcattaa cccgtttgaa ggactgtggt ccaatttctc agagccaatc agtgaaggct 2465101 ttcaaaagct gaacaagatt gtgccggagt acagaagaaa tgcatggacc aacggactga 2465161 aagcgcttgg gatcgatgat cctgcatatg gcgaatactt gggagagttt tttgcggcag 2465221 agcgcagaaa gcgcccgttt gtatatgatg aaacttttgc tgtactcgat caattaaaag 2465281 gcaagtatga attattgctt ttgacaaatg gcgatcctag tctgcaaaag gagaagcttg 2465341 ccggcgtgcc tgagctcgct ccttacttca atgaaatcgt catctcgggc gcattcggca 2465401 agggcaagcc ggatgtttca atttttgaac actgccttaa gctgatgaat attgaaaaag 2465461 acgatgccat catggtcggc gataatttga atactgatat tttaggcgct tcaagagccg 2465521 gaatcaaaac cgtttggatc aaccggactg ataagaaaaa cgaaactgac gtaaagcctg 2465581 attacatcat cagcagcctt catgatttgt ttcctatatt agagaaataa aaaaagcatg 2465641 atctcttcaa tgagatcatg cttttttatt ttattttttc gcttcagcta ctgccttttt 2465701 cacaaactca tcaagtgaaa tggtttcaga gttctgttct ccgtatttac gcacgtttac 2465761 cgctccgttt tctgcttctt ggtcaccgac caccagcatg tacgggattt tttgcatttg 2465821 cgcttcacgg attttgtagc cgattttttc atcgcggctg tcgacttcaa cacgcaggcc 2465881 ttcacattgc aggcgttcct gcactttttt cgcgtagtct aaatgcacag ccggagaaac 2465941 cgggatgact tggaactgaa ccggtgcaag ccatgtcggc agcgcgcctt tgtgttcttc 2466001 gattaagaaa gcaacaaagc gttccattgt tgaaacgaca cctctgtgaa tgacaaccgg 2466061 acggtgctgc ttgccgtcct caccgatgta tgtcaggtcg aaacgttccg gcaataagaa 2466121 atcaagctga accgtagaca gtgtttcttc ttttccgatc gcagttttca cctgaacatc 2466181 aagtttaggt ccgtagaatg ccgcttcacc ttctgcttcg taatagtcgt ggccgatttc 2466241 atccattgcc tctttcagca tggattgcgc tttgttccac atttcatcgt catcaaaata 2466301 tttctctgta tcttccggat cgcggtaaga cagacggaat gtgtaatcac ttaaaccgaa 2466361 gtcttcataa acatcctgga ttaaacggac tgtacggata aactcatcct taatttgatc 2466421 cgggcgcaca aagatgtgtg catcatttaa cgtcattccg cgtacccgtt gaagtcctga 2466481 cagcgcacct gacatttcat agcggtgcat cgttccaagc tctgcaatac gaatcggaag 2466541 ctcgcggtaa ctgtgaatgt cttgtttgta aatcatcata tggtgcggac agttcatcgg 2466601 acgcaataca agtgtttcat tgtccatttc catcggaggg aacatgcctt cctgataatg 2466661 atcccagtgt cctgatgttt catacagctc tttgctgcct agcacaggtg tgtatacgtg 2466721 ctcatagccg aggctgattt ctttatcgac aatgtagcgc tcgatgacgc ggcggattgt 2466781 tgcgcctttt ggcagccaaa gcggcaggcc ttgtccgact ttttgagagt tcgcgaacag 2466841 ctttaattct ttgccaagct ttctgtggtc gcgttctttc gcttcttcta gcatacgaag 2466901 atgctcttca agatcagctt ttttgaagaa agctgtacca tatacgcgct gaagcatttg 2466961 gtttttgctg tcaccgcgcc agtatgcgcc tgcaaggctt aacagcttaa attctttgat 2467021 ttttccggtt gaaggaacat ggacgccgcg gcacaggtca aagaattcgc cttgctcata 2467081 gatcgaaacg gtttctcctt caggaatcgc atccaatagt tcaagcttca ggtcgtcgcc 2467141 gatttccgca aaacgggctt tcgcttcttc acggctgact tcttttcgaa cgatcggaag 2467201 gttcgcatta acgatttttt tcatttcttt ctcgattttc ggcagatcct ccggtgtaat 2467261 cgcttcgtcc atttctacat cgtagtaaaa accgttttcg ataaccggac cgacgccgaa 2467321 tttaacatcc ttgtagatgc gtttaatcgc ttgagccagc aagtgagccg cactgtggcg 2467381 cataatttga agaccttctt ctgagccttc tgtaatgatt tccactgtac cgtcttcatt 2467441 gatcggcgtt ctcaaatcga tttcttttcc gttcagtttt ccggctaatg actttttctt 2467501 taatcccgga ctgatggatg ccgcgatatc ttctgttgtt gttcctttcg caaactcctt 2467561 gactgctcca tcaggaaatg tgatttttac catatctgac atctttgtca ctcctttttt 2467621 tgcatataaa aaccccgccc cctatgaaag ggacgaggtt gaataaacgg aatcgtggtt 2467681 ccaccctttt ttccgcaaag ccaatacacg gcacctgcgg ctctaagctc tgtaacggga 2467741 gttcccgtca gccattactg ttccttttca agaggttcac agctgaagtt caaaggcggt 2467801 aaagcgaatg gtccttagct gggaagcttg cagccagggc ttccctctct ttgagccggt 2467861 atcattcctt cgtgtcctta tcaatacgtg tgtctttctt aatctcctat gtattataaa 2467921 ttgttcaatc caaaaaatca acacgatcgc gtttcctttt ttttaaaccg acagccttaa 2467981 atagacaggc tgccggccct catccttccg agtgcttcac cggtatttct gcatctgtaa 2468041 aagcatgcag cgggagcatt tccactctct cttgaaatac gttttgaatg gtccttgcca 2468101 tcatgtgctc gggctggtcg gtataaagca cgacttcatc aggcgcaatg gaaatcagcg 2468161 gcgcgagcaa atgagaatca atatacatag gatgatcccg gacaaatctt ctgtctatgt 2468221 atttcatttt ttcccgttcc ggcacatagc gcagctccca taatgtaaag gaaccatcat 2468281 ggacaatatg cacttttttg attcgcggct gtttggcgtc cacatagtct ctgagtgttt 2468341 gaataaagtt ttgatattcc tgttccatct tatattcatc aatcgctgct tctgtaatat 2468401 ctctcagctg cttatagtat gatccaagtc ggaaggtctg aaaggagcga atgtaaaata 2468461 ctccttcctc taaacagatc gtttggagtt catccaaaat tgattgtttc cgtgaaagct 2468521 tcagcggctc aaacggaaga tcgtctgctt caccttcaat aatactgtgt gcgagctgaa 2468581 ggatttgctg ctgttcatcc tggtccgtga aacaatacgt ttcctcaatc aatgacagca 2468641 tatgctcgtc ttctttgcat tccaaaaaaa atttgaccag aatcggctcc ataaaacgct 2468701 gaataggaaa agccggattc gctttttcaa tcccgatttt tcgtatgcct tcacggacaa 2468761 tgatattgtt ccgatcgtcc gaatgctgaa tgagatgtaa aaaagcggct gcatcatggt 2468821 catcttcaaa gattatttca agcatgtttg tcccccctta cggcatctgt tacaagtata 2468881 tgggggatgt ttttaaaata gacgtaaagg tcattggcaa atcttaattt gattcttgga 2468941 acaagttttg cattttcttt ctgaagatga acggcaatga gataaacacg atatacaaag 2469001 cgagcaccat aaagaaagcg ggcagattgc cagccaaaaa gctcgcaccc agcacattaa 2469061 gcgcaatcgt cccagggatg attcccacag ccgttgcggc aaaatacggc agcgctttga 2469121 cattggaaag gcctgccgca tagctgacga aatcaaaatt gatcggcagg attctcaaaa 2469181 gaaagatata gaaaaatccg ttatcctcca tttgcttctg tatggcttca agcctttcgt 2469241 aatgcccgtt ctttttcgcc gaaaacaaac cagccgcaaa aaacgaaaca gctgaagcgc 2469301 acatcgaacc gaataacgta taaagcgtgc cgagaagcgg gccaaacgca agtccgccag 2469361 ctattgaaat aacagacacc ggaaataaaa caagtggcct gacgatggat atcccgataa 2469421 acatcagagg tgcaaagact ccgaacgaca atacccatac cctgatttct ttcggcgata 2469481 cattcaaata cgttttattt ccccaataga gtaaaccagc acctgcaagc actgccagcc 2469541 atttgacagc cgtttttcgt ttcataccct cagttccttc ccctttgaac cacagcaatt 2469601 atggatgtcg gcggttttct ccgtcaaggc ggatcggagc agccaaatat aatatccgct 2469661 ccattaatct tgcagctttt acttcttctt tttctcccct ctgcgaatac gtaaaatgat 2469721 gcttcagctc gtcaggtgag aaattagaag aaaagaacgt tggcagctgc tgggacattc 2469781 tgtgctgaag caccgttccg atgacctcat cccttaccca gcttgtcatt gattctgctc 2469841 cgatgtcatc aagcattaat acgggtgtgg tctttaccat attgagcttc tcttccaatg 2469901 tctggtcttg cagcgaattc ttaagctctc tcacaaattc aggcacataa acaatcatgg 2469961 aggaatactc tttttccgcc agctcattgg caattgcagc gagcataaac gtttttccta 2470021 ccccaaattt cccgtataaa tataatcctt tcccttttcc cgtctcatta tagcttttca 2470081 ggaagtctgt aacatgctga aacatcgcga gtctgcttgg gtcactgata tcaacttgct 2470141 ggaacgtcgc tccaagaaga tcctgctgga tatacatgct tttcataaga gactgttgtt 2470201 tcttctgctg gtcgagcttc cgtttgactg gacattcgta atactcgata tcaatagacc 2470261 tcccattgac aacaagcttc ggatggtagc cctccaacaa attgttgcag ttttcatctt 2470321 ccgaacaata ggagcaattc ttgctttgtt cgatatattc ataaagctta tttaagctct 2470381 tttcgatcat tttttggtca atcacttctt cgttttcctt caaaaatgct tgaacatctt 2470441 gatctttcat gactttttcc ttcatttgtt caagacgttt ttggaaatcc ggcctgccgg 2470501 ttacgccctg cagggaacgg ccgattggtt ccatctattc cttcaccccg catctctgtc 2470561 tttaataggc agagtatttt ttcagttttt gcatttcttc catcatcttt ttcttctgtt 2470621 cttccaaatc ctgcggatgc agcttctgct gtccggattc tgaatcggac gctgtttcct 2470681 tttctgtcat ccaatcagga agcttttctt cacgaatcac tttttggttt cgtttcgaag 2470741 actttgtttt tccctcagcc cattcaagat actggcggtt ttcttctatt gcgagcttca 2470801 tcgcttccct gaccgttttc acctttttgc gtgcccaatg cgaagcgatt ttttggatat 2470861 agtttttcga cagcttcatg tcggttttca gcatgacata ataaattaac acatttgtga 2470921 cgcctggctc gagcttctgt tcgaacataa tttcttctat gatcttcaga tcagcttttg 2470981 acggctctgt tccgtcagca atgtcctgca gaagcttctt cggggaaatc gcctccagca 2471041 atgcaatcag cttcccatcc agagaatcct cttctgccgg ttgttcgcct tcacgcagat 2471101 gcaccggctg tgttttttcc accaaatcgg gcagctgtcc gtttctttca atttgatacc 2471161 agtcgctcgc cgcttttctt aatgcctccg tcgtaatgac gtcacgctca tcaattgcgc 2471221 tcatcacaac attttgcatt tgcaaagggt caattccgta cagataagaa agctttttga 2471281 ttgtgtcccg cacctgctgg gtcatcgctt ttctcggtat catcgtctca gaaagtcccg 2471341 ctaaaaacaa atcaaaatca aacacatcct ccgttatggt gtaggacgga gactgtccga 2471401 cagaagtata ctcggacccc tcggcaagcc ttaccgtttc ctccatatcg gatgtgagct 2471461 tccattcact cggctgcagc gattcaaacg catgattaaa cggacgcgta atgtccttcg 2471521 catcttctga aatggccggg tgcgtaaaaa attgttttaa ttgctgatat ttcgtttttc 2471581 cgaccctatt atacagaaaa acattcagca ttccgtcttc aaaaaattca tttggtctga 2471641 gcggcggaag gagttcatat ataaagaggc gctcctgccg ctcggattct ttcatatata 2471701 ctttcagcaa tccgatgccc tcgagcttcc cctgttcctg atggatcgtt tttaagttgg 2471761 actgtgtcat ccccatcagc tgtctatgtg tggactctcc gccccacaga cggttttgtt 2471821 caagctctcc ccacaatgtc atataaagag agaatgcaac agggccgatt aagggctggt 2471881 acagttgtgt aataatttgt ctgtcaatat cctgcagcat cgatctgctt ttaaccacat 2471941 acgggtctac aggcagtaca tctttccaat agtcagccat acattctcaa accttccgaa 2472001 tttgtttcta cctttcattt tacaccgttt cttatatcta tcaaatgcca attttgcaca 2472061 tgagaaaaga gctagaagaa tcctcttagc tcttttaacg ctctttcttt attaagtctt 2472121 ttaattcatc gataaagacg tttatatctt taaactgccg atagacggac gcgaaccgca 2472181 catatgcgac ttcgtcaatc ttagccagcc ggtccatgac catttctccg acgagctcac 2472241 tcttcacctc ggagcagcct tgattgcgaa gttctttttc aatatcaaag cacatgtctt 2472301 caagcgtttt gagtgaaaca ggcctttttt cacatgcttt tatgaggccg cgcagcattt 2472361 tttctctgct gaattcctca cgcacacctt cttttttcac aacgatgagc ggggtttcct 2472421 ccactttctc aaaggtcgta aaccggtagt ggcaggattc gcactcgcgt cttcggcgaa 2472481 tcgactttcc gtcatccaca ggccgtgaat caaggactcg tgttccgtta tgctggcatg 2472541 aaggacattt caataaaatc agctcccaac tatatcgttc cctgcaatgt attttcggca 2472601 gcctccgcct tttaaaaata gatgtgacag catctgtcgg gagagccgtt gttaaatttg 2472661 tttctatagc attaggtggt ttgtgaaaat ctccttctta ttttacaaaa aaaatgaaaa 2472721 aagaaaaagc tgacactctc gtttctttat aaaaataaaa ggagcataag ctaaaaagcg 2472781 cataatggct ttctagcttc agctcccttt gtgttcgcaa tttactttat agtactttcg 2472841 cttgcgcctg tttaatttgc acaggcccca ttcctcttgg tatttcaatg ttttctcttg 2472901 tatcagcatg taatgcctct gcaatgtaat cagcagcgac attaggatct aagtctccac 2472961 aagtataaac atcaatgctc gcatatccgt gctcaggaaa actgtgaatc gttaagtgtg 2473021 attcagaaat aatcacaact ccgcttacgc cttgcggtgc aaatttgtga aatgcaacct 2473081 cgcgcacctc agcacctgat tttagagcag catttacaaa cgttttttca ataaaatcca 2473141 tgtcattcag cttatcaaaa tcgcatcccc atagctcgga gataacgtga cgccccattg 2473201 tttccatagt catggacccc ccttaacaag aattaaaaag tgaaattcca acaactgggt 2473261 cggccattta ccacggggga aagttagtcc ggagaggtcc taacccttta agtaattccg 2473321 aaacagtctc aagcaagaag ttcacgaaaa atagtatact gtgtttaagt ctaatttgca 2473381 aggtgcgttt tttcagaaat atgctgttaa gggttttttc tttaaaatgt gtccatgacc 2473441 ttattttata cagcagacgg atgtttcatt cgtgccgcta catggcggat tagatcaaca 2473501 actctgcagg agtagcccca ttcgttgtca taccacgcca gcacctttac tttcctgtct 2473561 tccattacca ttgttgtaag cccgtcaatg accgctgaat gcggattcgt attataatca 2473621 gtcgaaacga gcggttcatc tgagtaatca agtacaccgt acatcgacgt tttggcagcg 2473681 cgtttaaatg cctcgtttac ttcttcagcc gtaacatccg ttttcagatc aacaacgaga 2473741 tcaaccaatg agacgttcgg aacagggaca cgcaaggcga ggccgtgaag ttttcctttc 2473801 agatgcggca gcacaagcga aagcgccttt gccgctcctg ttgttgttgg aatgatggat 2473861 tcaccgcaag cccgcgcccg gcgcaaatct ttgtgcgggt tatcaatatt tttttggtca 2473921 ttcgtatacg catgaactgt agtcatcaga ccgctctcaa tgccaaactc ttcatccagc 2473981 acttttacaa caggcgcaag gcaatttgtc gtgcatgacg catttgaaat aatgacatgg 2474041 cgctcagcgt cgaattggtc ctcatttacg cccatcacaa tggtaacgtc ttcatttttt 2474101 cccggagcgg tcaaaatcac tttttttgca cctgcttcta tatggcccat cgctttatct 2474161 ttagcattaa acttccctgt tgcttcgacg actatgtcaa tatcatattc ccgccaaggc 2474221 agctgttttg gatcacggct gtttaacaaa agcactttct ttccatttac gatcaggcta 2474281 tcttcaccag ccacaacctc tttgtcgtat ctgccgtgaa ttgtgtcata ctttattaaa 2474341 tgagccagcg tttctgcgga atagctggcg ttaatggcca ctacttgaat ttgatcgtct 2474401 aacatcgctt ttctaaaaac cattcttccg attcttccaa acccgttgat cgctactttt 2474461 accttcatgt tggacacccc ttatcaatta tgccatccta atttgttact atctaaaatt 2474521 agtataacac attaaaacaa attcgccagt acatattgat aaaaatcaac gattataacg 2474581 ctaatttatg atgcatctta tgttttcttg cacagaatat caggcgtaag aaccaaaaag 2474641 cagccagcgc tccgcactga ctgccctcat gctttatgat tcctgtttta acttatcatt 2474701 gagcacactt tcttctagca cagaaaatgt atccccgtac actctgttaa tatgattcgc 2474761 tccccaagca cacagcatat ctaaaatccc ttctaagctg cggccgtatt cgctgagctc 2474821 gtattccact ttgggaggaa cttgattata tacgattcgg ttaatgacac cgtccgcttc 2474881 cagctcgcgc agctgctgag tcagcatttt ttgcgtgata ttgggcatta ggcgttttaa 2474941 ttcacttgtg cgtttttttc cgtgcgtcag atggcataaa atgacgcatt tccatttccc 2475001 accgatcact tcaagagtcg cttcaacaga aatgttatat tttttcttct ccatacaatc 2475061 cattctcctc acaggcacca aaaagtgact atagcacttc aaagtacgta cttttatttc 2475121 ttaacgatat gtttcataat cacatttgcc ggctgatttg aatctgctct tttttattta 2475181 tatagcttac tcggcagaat ttcaatcata caacacatct tacaaaggag gaacatcatg 2475241 acttcagcca ataaaagcaa tattcctgca ctactggctt tggccgtaag tgcattcgca 2475301 atagggacaa ctgaatttat cagtgtcggc cttttgccgc tcattgctga tgacctggat 2475361 attcccgtca cgacagcagg attgaccgtt tccctttatg cgctcggcgt tacatttggg 2475421 gcacctatat taacttcatt gacctcaagc atgtcacgta agacactatt gctttggatc 2475481 atgtttattt ttattgccgg taatacgatg gcagcaaccg cttcaagcat cgggatttta 2475541 ctagcagcac gtgtgatatc ggcattttcg cacggtgtgt ttatgtcgat cggttcgaca 2475601 atcgcagcgg atattgtccc ggaggataaa agggctagcg cgatttcaat tatgtttact 2475661 ggcctcactg tggcaactgt aaccggagtt ccttttggga catttatcgg ccagcagttc 2475721 ggctggcgtt tcgcctttat ggtcattatc gccgtcggaa tcattgcttt cattacaaat 2475781 ggcattcttg taccgtccaa attacgaaaa gggacgaaaa caacgatgcg ggatcaattg 2475841 aagcttgtga caaacagccg gttattgctt ttatttgtca ttacagcgct tggatacgga 2475901 ggaacattcg ttgtgttcac gtatctgtct cccctgcttc aggaagtaac aggcttcaaa 2475961 gccgggactg ttgcagtgat tctgctcgga tacggaatag ctattgctat cggcaatatg 2476021 attggcggaa agctgtcaaa ccgaaatccg attgccgctt tattctatat gtttatcgta 2476081 caggcaatcg ttctattcgt actgacattt acagccccgt atcaagcagc agggctcatt 2476141 accattctct gtatgggatt gctggccttt atgaacgtgc ccggccttca ggtgtatgtc 2476201 gtcatgctgg ctgagcgttt tgtcccgagt gcagttgacg tcgcatccgc gatgaatatc 2476261 gctgccttta atgcagggat cgcgcttggg tcataccttg gcggtgtgat caccgattca 2476321 atcggattga ttcataccgc ttggataggc ggattaatgg tggtcggtgc agtcatttta 2476381 acaggctgga gccgcttgat ggaaaaacga gatcggcagg aagcctgaca attttaaagg 2476441 aggaaataaa catgacaaca catttacaag caaaagcaac acttcataat ggggtagaaa 2476501 tgccttggtt cggcctcggc gtgttccaag tggaagaagg atctgaactg gtaaacgcag 2476561 ttaaaactgc cattgttcac gggtaccgca gtattgatac tgcagcaatc tatggaaatg 2476621 aagctggagt cggagaaggg attcgggaag gcattgaaga agcaggcatt tcaagagagg 2476681 atctgtttat cacatcgaaa gtatggaatg cggatttagg ctacgaagaa acactcgccg 2476741 cgtttgaaac aagtctgtcc aaactcggtc tggattattt ggatctatac ctcatccact 2476801 ggcctgtaga aggaaagtat aaagaagctt ggagagcgct tgaaacgctg tataaagaag 2476861 gccgtatcaa agcgattggc gtaagcaact tccaaattca ccatcttgaa gatctgatga 2476921 cggcagctga aattaagcct atgattaacc aagtggaatt tcacccgcgc ctcacacaaa 2476981 aagagttgat aagatactgc caaaatcagg gcatccagat ggaggcttgg tcacctttaa 2477041 tgcagggaca gctgctggat caccctgtat tggctgacat cgctcaaaca tataataaat 2477101 ctgtcgcaca aattattttg cgctgggatc tgcagcatgg cattataacg attcctaaat 2477161 caacgaagga acaccgcatt aaagaaaatg caagcgtatt tgactttgaa ttaacgcagg 2477221 atgacatgaa ccgaatcgat gcactgaatg aaaacttgcg cgtcggtcct gatccggaca 2477281 actttgattt ttaatggcca aaaaacaccg ttcaatatga acggtgtttt ttgtattatg 2477341 cccagctgtt catgatttca tcaagctgcc ttttggtctc ttcaagcgtg ccgctgttat 2477401 caatgacttg atctgctctt gctgtttttt cctctaaggg catttgagag cggatacggc 2477461 tgactgcttc ttcttctgtc agctgattgc gcttcatcag acgttccagt tgaagctctt 2477521 ttgtcacact gaccacaata attttatcaa ccaatgattc caatttgctt tcgaacaata 2477581 gcgggatatc caatacaaca aatgcctccc gatttgcaac ggcttcatca cggcgattga 2477641 gcatttcctg cctgactgcg ggatgaacaa ttgcatttaa agcgagacgt ttttgttcat 2477701 ttgtaaatac cagcgctcca agcttttttc tatctatatc gccatttgag agcagtatgt 2477761 cttcaccgaa ttcgtcaatg atttgccggt aggccggcat ccctttttct accgcttgtt 2477821 ttgcaatgat atctgcatct ataactgtta ttcctttttc aatcagcata ttggctaccg 2477881 tgcttttgcc gctagctatt cctcccgtta aaccaatgac taaggtcaag agatccactc 2477941 ctttttacaa tttccagagc ccaatcgtga ttaatagaag ccccggcaaa aacgccattt 2478001 tatcgatcca tttccactta gacagaaaat ggccggcatt gattccaatt gatacaaaca 2478061 gcgagctcat gattgccacg gcgatgctca tcacaatcgg cgaaaaaccg agaatggctg 2478121 cgcctatacc tgctccaaag gcatcaatcg ataaggcaaa tcccaataag accgcctcaa 2478181 ttccgttgat cacacccgat ttgtcgatat ccgcactcat gggttttctc aaaatatgaa 2478241 tcacaattcc taatgaccga acctctagat taagcagtgt tttttcatgc aataggtatt 2478301 ctttatcttt tgccggtttg aaaaattgat acagaaccca cgcaccgatt ccaaccaata 2478361 tcaaaccgcc aagcttctcc gtcacatata caggaaaaaa cttcgtgaga aagcttccga 2478421 tcagcatgga tataaacatg acagcaccgg aacagcaggc gataaccaaa atcgctttaa 2478481 acggtatttt catttttctc aatccgtacg taaatccgac tgaaaaactg tccaagctga 2478541 cagccaacgc cagcagcagt atagaaacca tttgcatatc cgtttcttcc tttctgttgg 2478601 tgctcttgta tcagatgtga aatgcccggg attcatcaca atcatatata tgggaaagtg 2478661 aaaaatccgt gtttcgaaaa tggcatcctt aatccagagt tactgatata tgcaccgaca 2478721 gcttggacaa tgaagcatta tgctactttt ttgtctggca ctttgcgcaa aaatgcgtgc 2478781 ctcttcctcc aacgacaatt ttcgaaatca tcgttccgca atttttgcat ggctcgtctt 2478841 tttttccgta cacaaaatgc tgcagctgga acattccgat ttccccttgg gagttgatat 2478901 atgaacggac tgtgcttccg cccgcatcaa tcgcctcctg cagagtgttt ttgatttcag 2478961 cgtgaagggt tttgattgtt ttatctgata attgatttgc ttttgtctcg ggatggacac 2479021 ccgctctgaa aagagcctca tccacataaa tgttcccgag tccaactacc gttttttgat 2479081 ccagtagggc agttttgaca gcgcggtttg ttttcgcaag ccggtctttt aaatacgcac 2479141 ttgtaaattc ttctgcatcc ggctccggcc ctaactgaga aagcgggagc tcgcccgctt 2479201 cttctcccgg tttaaataag tgcatggttc caaatttccg cacatccctg taccggagct 2479261 gggttccatc cgtcatcgtg aatatgacat gcacgtgttt atcgtcaggc tcctcggctt 2479321 gatgaagacc gtattttcct tccattcgaa ggtgagaaac cataacataa tgatctaaat 2479381 gaaacagtaa aaactttccc cgtcttccga tggactgtat cgtttctcct gctagttttc 2479441 gcgcaaattc ctccggttcg gcaggccgtt tgatgatatt cggccatctg atctctaccg 2479501 atttgattgt ttttcccttt acaagcccgg tcagagtgcg ccggaccgtc tcaacctctg 2479561 gtaattccgg cacatccatc acttcctatc tctgtttatt tcgcatcgta ccaagatggg 2479621 cctgatgcaa agtccacctt taacggcaca tctaatgcaa gcgcatgctc catcacttca 2479681 ggaacaagct tttcaagaat ttcaatttct tcctttggcg cctcaaaaat caattcatcg 2479741 tgtacttgaa gcagaagcct tgctttcaac tgtttttctt tcagcttggc agccatgtca 2479801 atcatggctt ttttgataat atcagcggcg cttccttgaa tcggcgtatt catggccgtc 2479861 cgctccgcaa aacttcggat attaaagttc cggctcgtca gctcagggat gtagcggcgg 2479921 cgatgcataa gcgttgttac gtatcctttt tgtttcgctt cctgtactga atcttccatg 2479981 tacgctttta cgccttggaa gctttccaga tagcggtcga taaatgctcc cgcttccttc 2480041 cgggtaatgc cgaggttctg tgacagaccg taatcgctga tcccgtaaac aatgccaaag 2480101 ttgaccgctt tcgcctggcg tctcatcgca gatgtcactt catccttagc gacatggaac 2480161 acatccattg ccgttttcgt gtgaatatcc atatcattag taaaagcttc gatcagattt 2480221 tcatcctttg aaatatgggc aagcacccgc agctcgattt gtgaataatc ggctgcaaaa 2480281 atgagccagt ctttttcaga cggcacaaaa gcttggcgaa ttttccgccc ttcctcaagc 2480341 ctgatcggaa tgttttgcag gttcggatca gtcgagctga gacggccagt ttgcgttaag 2480401 gcctggttaa atcgcgtgtg cactttatgc gaatccggtc tcgtcacctt taaaagccct 2480461 tcgatatatg ttgattgaag cttgccaatt tgtctgtact gtaaaatata gtcgacaata 2480521 tcatgcttgt cagccagctt ttcaagcaca tcggcagacg tagaatagcc tgttttcgtt 2480581 ttctttacga caggaaggcc gatcttttca aataagatga cgcctagctg tttcggagaa 2480641 ttgatgttaa acggctctcc cgcaatctca tggatttttt cttcatattc cttcagcttc 2480701 gcacccagtt cttcacccat ccgttttaaa cggtcaacat cgaccttgac gccagttgat 2480761 tccatttcgc caagaataag cgcaagaggc atttccagct cttcaaacag ttcaagctgg 2480821 tcgttgtttt ccagctcttg aacgagcttt tcccgaaggc tttgaatcgc taacgctttt 2480881 cggccaaggt gctcagacag tacgtcttct gacggcactg cccgttttgc tccttttcca 2480941 taaactgatt catcacttga aacgatatgc aggccgtaat ccttagccac actcgcaacg 2481001 tcgtcatatg aattgcccgg gttgatgata taagccgcaa ggagcgtatc aaactcggct 2481061 cctttcagct caatgccctg ccagcgcaaa gcgacaacgg cccgcttgct gtcgaagacc 2481121 catttcttct gctcgtcatt ttccacccat tctttaaaca cctcagactc aacggcaatg 2481181 tctttcggaa tgaaataagc tcccgtttca tttacgatcg aaaatccgag gatcggctct 2481241 tcatgataat tatcgccaat ctgttcaacg acaaatgcgg atggagaaac caatatatcg 2481301 cttgtcacgt ctgtgactgt tttgacatta atgtcttcca acgattgatc ctgttctgct 2481361 tctgcactgt cttctccaag ccgttcaaga agcgtgttga agccaagatc tttaaagatg 2481421 gcaatgacct gttcacgatt aaagccttga tattccaggc cggaaacaga tacctcaatc 2481481 ggagcatccg tcataattgt cgcaagctcc ttgctcatca atgcctgatc cttaaactcc 2481541 tcaagctttt ccttcaattt ctttccgctc acctcgtcaa tggactccag cagcttttca 2481601 acggaatcaa attgttttaa aagcttaatc gcagtctttt ctccgacgcc gggcacaccc 2481661 ggaatattat ctgaggaatc gcccatcaga cccttcatgt caatgatttg ttcaggcgta 2481721 agcccatatt tctctttgac atgctccggt gtgtaaaatt caacatcggt aattcccttt 2481781 ctcgtaatgg caactgtcgt tttgtccgtt gccagctggg ttaaatcctt atctcctgag 2481841 aaaaccttaa cttcaaatcc gtctttttca gccgatttgg ccagtgtgcc gataatatca 2481901 tccgcttcat attgttccag ttcatagcgg ctgatctggt aggcatccag cagctcgcgg 2481961 ataaacggca tttgttcgga aagctcaggc ggggttttct gtctgccgcc tttatattct 2482021 ttaaatgtgc cgtgacgaaa tgttgttttc ccggcatcaa acgcaaccag catgtgcgtc 2482081 ggtttttcat cctcaagcat tttcatcaaa atcatcgcaa agccgtatac agcattcgta 2482141 tgaacacctt tatcattgct taacagcggc aatgcaaaaa acgcccggta agccagactg 2482201 tttccgtcta caagcactaa tttttttcgt tccgtcattc aatttcctcc taagaagcct 2482261 caggcttcca ttcatctctt acatagtcat tagctcctct tattttaaca aagttcaatt 2482321 tgaaaggaaa atacgtgaac tataagagaa gacacaaaaa aggacgggaa cacaaatagg 2482381 ttcccgccgt caaaattggc tccttggatg aaggggttct actacatcct accagcatag 2482441 gtttaacagt gcatgaagat attgttaaac ctttgtaaac attaggcgga cttttcagcg 2482501 gcccgtttca gcgtcacggt aaagacagtt ccccgtccaa gctcgcttgt gacatcaatt 2482561 ttcccttcat gagcctctat taaatgcttg acaatcgcta ggcccagccc ggttccgccc 2482621 gaatttctgc ttctgtcttt atctacacgg taaaagcgtt caaagatgcg cggaatttct 2482681 tctttctgaa ttccgattcc agaatcggca acctcaatct gaatgtcttt ttctctgggc 2482741 tttacattga tagccacgga gcccccctca ggcgtgtagg ttaatgcatt gtttacgaga 2482801 ttaagaaata cctgtttcag cctgtacggg tcaccagata catattgagg gtctttcggg 2482861 acattcaggt gcaaggagat gcctttctca tccgccttat gcttcagaag cgtttcaatc 2482921 tcaccaagca ttttggccgg ctcaaacgtt tcgatactga gcgtgaaatt ttgctgctcg 2482981 atttttgaga gatcgagcaa atcctgaacc aaagactgaa gcctttcgct ttccttaaga 2483041 ataatagaga gaaattcaga aagcgcctct ttgtcttcca tcgccccgtc caataacgtc 2483101 tccgtaaacc cttttatgga cgtaatcggt gttttcagct catgagaaac attggccaca 2483161 aaatccttcc tcatctgctc taatttcttc gtttccgtca tgtcatggaa aacgagcaca 2483221 attcctttcc attcatcgtc cggccccata atcggaacgc cgtccacttc aaaataacgc 2483281 cgttctattt tgatcggcag tcttaacagc ttgcatttct ttgtctccgt cataaaaatg 2483341 tcttcgacaa gctggatcac ttcttcatgt tcaaatgcat cgtgataaag acggcgcagc 2483401 atatgattcg gattgatatg aaactgcttg gcgtaagacc tgtttacgag attaataaag 2483461 cctcttccgt cgatcataat cagcccggag ccaatgtttt caatgactgt cagcagccga 2483521 tcccgctgca tttcctgcgt tcgcgtcatt tccatcagat caatggcaag gctgttcatc 2483581 gcatgtccta gcttatcaga acgcctaata tagccgccgt acgtccgtgc atcgtagttg 2483641 cccttagaga gttctgtggc tacatttgtc gctgactcaa ttgacctttt ataacgtgag 2483701 gtcatgctgg aataaaaata aacaatgacg ataaatgcgg tacaaagact ggccgtcagc 2483761 atcccccaca attcgccttt taagccgtcg cttttttcag aggcggaaag cagcacatat 2483821 cctgtttttt caccttcgct tctaagtgaa agtccgtaat aaagcttgtt atctgttgtt 2483881 gacagaatac cctcatggcc agaaacaagc gcctgcacct tttgggaatc agccgatcta 2483941 ccgtttgacc catacagcac cttaccgtct gtatcgataa cggatgcgct cacatcaagc 2484001 gcgccgcctg catctttaat gattttctca tttgcttgat tattcagatt gccggcatca 2484061 agaagcgaag ccaagtattt tgcttctttt tcaatgtgtt cctctgcttt cctttgatca 2484121 gatgtttcaa aaagctgctg taaaaacagc ccgaggacac aaaacaccag aatcatacag 2484181 acaacgaata cagaaaaaag gcgcacacgg tatttattca ttcatttttg gctcctccag 2484241 tttatacccc aatcccctaa tcgttttaat gtagatcggt tttttggtat tgttttcaat 2484301 tttgtcgcga agatggctga tgtgcacatc aacaattctc gtatctccgg caaaatcata 2484361 attccagact gcgctcagca gcaggtctct tgtcagaact ctgcctttat gtctgcctaa 2484421 atagagcagc agttcgaatt ctttcggtgt cagttcaagc tgactttctt taaagtacgc 2484481 ttcataatga tcaggcagga ttttcagatc gccgattacg atctggcctt ccatttcatc 2484541 gttcttcatc tcactagagg gcgcagctat ttccgaacgc cttaaaatcg ctttgactct 2484601 cgcatttact tcccttggac tgaacggctt ggtcatataa tcatcagcac cgagctccag 2484661 ccctaatact ttgtcgaatt cctcatcctt cgctgtcagc attaaaatgg gaaacatcag 2484721 tttttgctgt ctcagctgct tgcatacttc gattccgtcc aattttggaa gcatcacatc 2484781 aagcacaatc aaatcaggtt tctctgtttc cgcttttttg agtgcttctt ccccatccga 2484841 ggcggtaatg acatcatagc ctgaccgttc caaattgtac tgtaaaagag taacaataga 2484901 ttcttcatca tccacaacta aaattttctt gttcatgctg tgcctccagt attataattc 2484961 cccgacatcc tatttctcta ttttatgtca tcttaacatg tttcatgatt ttattttagc 2485021 gaaagcagga cattccgaca attcgccttt tacatcattt ttaaaagaaa taaagacgtt 2485081 tatgatagcg ctttcattta tagtaaaaag agaaaggctg tattaagcaa gcctttctct 2485141 ctttttatta ggataatact ttcatgacat ttttgacaga ttcaactgat ttattcagct 2485201 gcgctctttc atagtctgtc agttcaagtt caatgatttg ctcaagaccg ttgccgccta 2485261 caattgtagg aacaccaagg tagatgcctt catagccgta ttccccttca agataagcaa 2485321 ttgtaggaag gacgcggcgc tgatctttca agatcgcttc gaccatttct gtcagagaag 2485381 ccgcaggcgc ataatacgcg cttccgtttc caagaagatt cacgatttcg cctccgcctt 2485441 ttctagtgcg ctccacaatt gcgtcaatcc gttctttcgg aataagagtt tcaagcggga 2485501 taccgccagc ataagaataa cgcacaagcg gaaccatatc gtcaccgtgt ccgccgagta 2485561 cgaaaccagt cacatctttc actgacaggt ttaattcctc tgccacaaat gttctgaatc 2485621 ttgccgtatc aagcacacct gactggccga ttacacgctc tttagggaag cctgattctt 2485681 tgtacaccgc gtatgtcatt gcatcaacag gatttgtcag caccacaata atagagtcag 2485741 gagaatattt cacgatttcc tgcgtaacgc ttctcataat cttttcgttt gtagagacca 2485801 gatcatctct gctcatacca ggttttcttg cgataccggc tgtaatgaca acaatgtcag 2485861 agccggctgt atcctcgtaa ttggatgttc ccgtaatttt tgcgtcaaag ccttgaaccg 2485921 ggcttgcttc aagcatatca agcgcttttc cctttgtcgg gttctccaat tgcggaatgt 2485981 caacaagaac aacgtctgcc agctcttttt gagcgattaa aaatgcagtt gtagctccgg 2486041 taaaacctgc tccgataaca gaaacttttt tacgagtatt tcccatgtct ctcttctcct 2486101 ttatggctag ttttaggctt tttccttgct tagtccatgt ttttgatcag ttcttctccg 2486161 aactctgaac atttcacttc agtcgccccg tccattaatc tggcaaaatc gtaagttacg 2486221 actttagaag cgattgtttt ttccatagat ttgataacca aatcagccgc ttcgttccat 2486281 cctaaatgct caagaagcag aacgcctgaa agaataactg aagatgggtt tactttatca 2486341 aggcctgcat atttaggagc cgttccgtgc gtcgcctcga aaatcgcatg tcctgtttcg 2486401 tagttgatgt tcgctccagg agcaatgccg attccgccga cttgcgcagc aagagcatca 2486461 gaaatgtaat ctccgttcaa gttcattgtc gcaacgacat caaactcgtt tggacgcgtt 2486521 aagatctgct gaaggaaaat gtcagcaatg ctgtctttga taatgatttt tcctgctgct 2486581 tccgcttcgc tttgcgcttt gttggcagcg tcttttcctt gttcttcagc aatgcggtca 2486641 tattgagccc atgtgaagac tttatctccg tattcttttt cagcaagttc atagccccag 2486701 tttttgaagg cgccttctgt gaacttcatg atgtttcctt tgtgaacaag tgttacagat 2486761 ttgcggccat gctcgatcgc ataatcaatg gcagctctga ccaagcggct tgttccttct 2486821 tctgaaacag gcttaatgcc gatacctgat gtctcaggga aacggatttt attgacgttt 2486881 aactcatttt gaaggaagct gataagcttt tgcacttctt cagagccttt tgcatactcg 2486941 atgcctgcgt aaatatcttc tgtattttca cggaagatga ccatatcagt atcttcaggg 2487001 cgttttaccg gtgacggcac tccagtaaag tatcttacag gtcttaagca gacgaatagg 2487061 tcaagctctt gtctgagcgc tacgttcaaa gaacggatac cgccgccgac aggtgtcgtt 2487121 aacgggcctt taatcgcgat gaaatattcg cggatcacat ctaatgtttc agcagggagc 2487181 cactcacctg ttttattata agccttttct ccggcgtaaa cttctttcca tgtaattttc 2487241 ttttcgcctt tgtatgcttt ttctactgct gcttccaaaa ccttcgaagc cgcgttccaa 2487301 atatcaggac cggttccgtc tccttcgata aatgggataa tcgggttgtt tggtacgttt 2487361 aatactccgt tagagactgt aattttttca ccttgtgcca caataaaaac ctcccagtat 2487421 gtaattcata tttagaaaac attttatttt tcttatatag aaaataaaat gatttttcct 2487481 aacattcaat ttaaagtgta acccaatttt gatgtctgaa caagaggcta acctcattga 2487541 cgcaagccag cctccaatgg ttctttaggc tctttcttca atcggaacga atttttgttt 2487601 gtcagggcct gtgtaatctg cccgcgggcg gatcagacgg ttgttgtcat actgctcaag 2487661 aatatgagcg agccagccgg acattctgct tacagcaaaa atcggtgtaa acaaatcatg 2487721 gtcaataccg aggctgtgat atacagaagc cgaatagaaa tcaacgttag gcggaagctt 2487781 tttctctgat gtgacgatgt cttctatacg aatcgacatc tcataccatt tgctttcgcc 2487841 tgtcaggttg gtcaggcgct tgctcatttc tttcagatgc ttcgcgcgcg gatcaccatg 2487901 cttatacaca cggtggccga atcccatgat tttttctttc ttttcaagtt tagcgcggat 2487961 gtacggctca gcgttttcca cttcaccgat ttctgtcagc attttcataa cgccttcatt 2488021 cgctccgccg tgaagaggcc ctttcagcgc gccgattgct gcagtaatgc ctgaatagat 2488081 gtcagaaagt gttgcgacgc agaccctcgc tgtgaacgtt gacgcgttca gctcatggtc 2488141 agcatgtaaa atcaatgctt tgttgaaggc ttcaacttca attggtgaag gctcttcacc 2488201 gtttaatgtg taaagaaaat tctccgcaat accgtaatct tctctcggtt caacaggctc 2488261 aagacccttg cgaattctgg aaaacgctgc aaccaggcca ggcacctttg cctgaaggcg 2488321 gatcgccttt ctgtagttgg cttccgggtt catggtatca gcctcgctgt caagcaggcc 2488381 tagtaatgaa attgctgtcc gaagagcagc catgggatga acattttcga gggaataaga 2488441 tttgaagtgc tcaataattt cttgcggaac ggcagcttcc tttgcaagct gctgctttaa 2488501 ctcttcaagc tcttttttgt ttggcagcct tagatgccaa agcaagtaga tgatttcttc 2488561 aaaacttgca ttctctgtca aatcatcgat atcatacccc acatatgtaa gggtatcatc 2488621 aataatagaa ctaacagatg atgttgttgc tacaacccct tcaagaccgc gtgtcgctgt 2488681 catatataac atctcctttt caataaattt cccctttaag agtgttgtaa aaacatgagg 2488741 cttacttaaa aagcacgatg caagtatttc tctcccccaa aaagaaaatg cttacatttt 2488801 actggctgct ggaactaaaa ccctttgctt ttgaaagaac ataacaaatt tttataagct 2488861 tatttaagtt taagcctatt ctcattataa acaataatca gacatttgtt aaatgtttac 2488921 ctataatttt ttttttccat tctgtgattt ccccgaaaaa acgcctttat ttgcgggttt 2488981 ttgcataaaa aaaagcggct ttaaggccgc ttttttttat gaagtgaaca gttttacgat 2489041 ctgcatggct aaataagcaa tccccgctcc gatcagcggc cccaccgcaa ctcctccaaa 2489101 aagcgcgact gcaagaatgg tcccgatcac gagagcagtt gtaatatgcg gatcattttc 2489161 aagcagggtc aggccgtttt ttgcaatcag cgccactgcg atccccgctc caagggcgat 2489221 ccatgcgtag gaagaccgca ttgcttctcc aagctgctta aatccgattt ctcccgtggc 2489281 aatcgggaca agaacggcga tggtaataat ggtcacaccc cagttaatgc cttttgactg 2489341 gatggtcgga aataatttct gatcaagccc aacgattttg atgatcaaaa ggacggatac 2489401 agcaaagagc aatgattggt tttttgcgat aagtgcgata gccaagagta aaattaaaaa 2489461 taaattcgct tgtgtaaaca catgccatcc ctcctttaag atgaatgtat tcatattcag 2489521 ccgcagcgtg aatacatata aaaaatagga catgctgacg agaggaggac cgtttttgtg 2489581 aatcaatctt atatcactat ttttttcaga accctctttg tcatatcaat gaccgcaggg 2489641 tcgatagctg cggcctatta ttcgtttccg ttaacttatc cgttcctgat cgcccttatt 2489701 ctatcttcag tgattcatcc tgttgtcgat tatttggaca aagtgacagg attcccccga 2489761 acgataaatg ttctgggcgt tcttgctttt tttctgctcg cagccttcgg cgtgctcacc 2489821 attctggtag ccgaaatcgt aacgggaaca gcctatctag caaaaacgct gcctccgcat 2489881 atcagcacgt ttatttcata ttgcgaaaaa ttgtttacca ctcatattca gccgctctat 2489941 aacgagttaa ctcttttgtt tcaagaattg gaaacgaacc agcaggcttc catcgtcact 2490001 catatccaga cactcggtga ttctgccgct aaaaatgccg ggctcctgct gtcccacatt 2490061 ctagagatga tcccgagatt tttcgctctt cttcccaata cggcggcggt tctgattttt 2490121 tctcttctgg caaccttttt tatgacaaag gattggcata agctgaaagc catgcttgtt 2490181 ttaattctgc cggatcgtgt gacagctaac agcaaagcaa tcagcagcga attaaaaaaa 2490241 gcaatgactg gttttatcaa agcacaagcc gtcctcgttt tcatcacgat ggtgattgta 2490301 tttatcggcc tttctctctt aaaggttgaa cacgccgcaa caattgcttt tttaatcggg 2490361 cttgtagatc ttctccctta cttaggtgcc ggctccgtat ttgtgccctg gattttgtat 2490421 ttatcgatta cgggccagct gccccaagca atcggaattg gtatcctgta cctcgtcgtt 2490481 cttattcagc ggcagctgac agagcccaag atactaagta aatctatcgg gatcgatccg 2490541 ctggcaacac tcatcgccct gtttgccggc tttaaattat tcgggttttt aggactgatt 2490601 gcgggaccgg ctgtactcgt catcatccaa gctttcatca caacaggcgc attaaaagaa 2490661 atatggtcct atatcaccgt tcagcaaaaa taaaacggca gccgtttttt catggctgcc 2490721 gttttttatt tgatgatgat ccgcttattc ttcgacattc ctctcagcca tttgaacaga 2490781 atcggcttac accagccgcg ggtaaacggg ataagaagac aggcgccggc caaatctgat 2490841 aaaaagcccg gaagcatcag caatagaccg ccaatgaaaa tgcacagacc gtcagcaatc 2490901 gcttctcccg gcattttgcc atattgaaga tcacgctgaa ccttataata cacttcggtt 2490961 ccttgttttt ttgcagctgc tgcgccgata atgccagtca gaatcatgaa tagaactgtc 2491021 ggcaaaatac caatcagatt tcctaaaaat aggaatatac cgatttctat tgccggaaac 2491081 acaataaaaa gcaaaaacaa aaatctcata tccaagcccc ccacacgtgt aacacgttct 2491141 gttcaacaaa aggcatgata aagagaaaag gaagggattc cccttccatt ttcacctgta 2491201 attaaagaac gctcgcacgg ccttgataga ctgcgcctct ggaagcgtca actgtaatat 2491261 cctggccatc tgtcaaaata gatgtcgcat tttccagacc cacgataacc gggatgccaa 2491321 ggcttaatcc gactaccgca gcatggctag tcaaaccgcc ttcttctgta ataagagcag 2491381 acgctttttc aagggatgca atcatatcac ggtcagtgct tttggtaaca agtaccgcac 2491441 cgtcagtcat tttttgctca gcttcttttg cattttgtgc aacgacaacc ggaccgtaag 2491501 ctgatttgcg tccaatgcct tggcctttag cgatgatatc gccgacagta tgaaccttca 2491561 ttaagttcgt agtgccggac tcaccgacag tgccagctgt aataacgata agatcgccgt 2491621 gttttacaat tccgctgttc aatgattttt ggacagcatc ctcaagcatc tcatctgttg 2491681 agctcgcatt ttggccgctt tccgcgaata cgccagatac gagggcaagc tttctggaaa 2491741 tagagtcatt tacagtaacc gcaacaatcg gagcctgcgg acggtatttt gcaatcatac 2491801 gtgctgtatg gccgctttct gtcggcgtta cgatcgcagc agcattcagg ttaatcgccg 2491861 tatgtgcgac agattgtcca attgcgtctg taattgtcat gcccacttgg tctctgcgtt 2491921 ttgagagaat ttctttataa tttaatgctt cttcagaacg ggacgcgatg ttatgcattg 2491981 tttgaactgc ttcaaccggg taacttccgg cagcagtttc accagaaagc atgatcgcat 2492041 ctgttccgtc gaagatcgcg tttgcaacgt cacttgcttc cgcacgagtc ggacgcgggt 2492101 tgcgctgcat gctgtcaagc atttgtgtcg ctgtaataac aggtttgccc agcgcgttgc 2492161 attttttgat cagttctttt tgcacaagcg gcacttcttc agctggaatt tccacaccta 2492221 agtctccgcg tgcaaccatt aagccgtcag acacttcgag aatcgcatcg atgttgtcaa 2492281 cgccctcttg gttttcgatt ttagggatga tttgaatatc ctgagcgttg tgctcttcaa 2492341 gaagctcacg gatttcgagc acatccgtag aacgtcgaat gaaagatggt gcgatgaagt 2492401 ctactccttg ctcaataccg aaaacgatgt ctcgcgcatc cttttcagta atccccggaa 2492461 gattgacact tacgcccggt acgttaacac cttttttatt tttgagtgtt ccgttgttta 2492521 atacttttgt tttgatttcg cgtttagcgg catctacatc aagtacctca agaccgataa 2492581 ggccgtcatc taacagaatc gttgaacctt gttcaacgtc atggactaaa ccttcatatg 2492641 tcactgaaat tttatctgtt gttcctacaa cctcgtccat tgaaataatg agctctttgc 2492701 ctgtttcaag ctcaataccg ccgttttcca ttgtatgtgt gcggatttca ggaccttttg 2492761 tatcaagcag aattccaacg ttcttgccaa gttttttact tgcttcgcgg atatttttaa 2492821 ttcttgcacc gtgctcctca aaatctccgt gagaaaagtt taatcgagcc acgttcattc 2492881 ctgactccat taatttcgta agcatttcaa tactttcact tgccggaccg atggtacaaa 2492941 caattttagt ttttctcatt tggttcactt ccttctgaaa tcttcagcct tcagctgtac 2493001 attagataga cagttctttt gaaagctgat acatgttttg ctcaactgtg tgttttgtct 2493061 caagtatttc tataatatca tggtctacaa gcttattgtt ttgtatacct acacagcgtc 2493121 cgccttttcc ttcaagcagc agttcaactg catatgcgcc gagacggctt gccaacacac 2493181 ggtcagcagc actcggagaa cctccgcgct ggatatggcc caatacagat accctagttt 2493241 caagatttgt ttcttcttca atgcgtttcc cgaattcaac accgctgcct acaccttcgg 2493301 caacaataat aatactgtgc ttcttgccgc gttcgtggcc gcgttttaag cgggcaatga 2493361 tttcgtgcat gtcatagtct gcctcaggga ttaagatcga ttctgcgccc cctgcaagac 2493421 cggcccacaa tgcgatatcg ccggcatgac ggcccattac ttcgattaca tatgtacgtt 2493481 catgagaagt cgctgtatcg cgaatcttat caattgcgtc aattactgta tttaaagctg 2493541 tatcgaaacc gattgtaaaa tcagtgcccg gaatgtcatt atcaattgta cccggtacac 2493601 ctacacatgg aaacccgtgt tccgttaatt ttttcgcacc catataggaa ccgtctccac 2493661 cgataacaac aaggccttca ataccaagct tcttcaagtt tgctatccct ttttcacggc 2493721 cttcaactgt tttgaattca ggacatctcg ccgtataaag cttagtccct ccacgatgta 2493781 taatatcgcc tactgatccg agttcaagct tttcaatctt tccgctgatc aatcccgcgt 2493841 atccgttgta aataccgtaa acttcaacgt catgatagat cgcttttctg actactgcgc 2493901 gaactgctgc gttcattccc ggggaatccc cgccgctcgt taatacccct attcgtttca 2493961 ttctccattc acctcagcaa catatatgat taaacataac atgatcattg ccctaaaaac 2494021 aatgaaaagg gatctccatc ctccctatga aaccttacct attatacaat taaataaatt 2494081 gtttttaaat aaaatttaag gaatgtcaca aaaaataaac gtgagccaaa ggcttcacgt 2494141 ttatttagtt taccccgata tattgatctt caaccgagac tttgccaatt gctttatatt 2494201 tttcataacg ctgctgaact aattcttctt cgctcagctt cagtaaagtt tttaacgatt 2494261 gtttaagggt ttcgtccata tagcttgcct gcagcttcac atcatggtgc gctccgcctt 2494321 ttacttcttt aatcatatga tctataatac ctaattcttt taaatccggc gcagtgattt 2494381 tcattgtttc tgctgctttt ttagcaagac tggagtcctt ccataaaagt gccgcggcac 2494441 cttccggaga aataacagaa taagtagagt tttccagcat atgcaagtga ttgcctacac 2494501 ccagaccaag ggctccgccg cttccgcctt caccaatgac gatgcagata acaggcactc 2494561 gaaggccggc catctcaaac aggtttttgg caatagcttc actttgtcct ctttcttcag 2494621 ctgctcgtcc agggtatgcc cccttcgtat caataaaaca gataattggt ctgttaaatt 2494681 tgtcagcctg tttcatcaga cgaagcgctt ttctgtagcc ttctggatgc ggcatcccaa 2494741 aattgcggac taggttttcc ttcgtgtctt tgccgcgctg atgcccgatt accgttacag 2494801 ggaggccgtg gaacttcgca atcccgccga caatggcttc atcgtccccg tacgctctgt 2494861 ctccgtgaca ttcaaaaaag tcggtaaaca ggtgttcgat ataatcaaga gttgtcggac 2494921 ggtccgccag acgcgcgatt tgaacccggt cccacggctt caaatttttg taaatatcat 2494981 cctgaagctt agcgagacgg tcttcgagcc gttcgatttc cgcacttaga tccatatcgg 2495041 aatcttgggt gaattttttt agttcggcga ttttggtttg cagttcaatc accggttttt 2495101 caaattctaa tcttggagcc actcaatgtc acctcctgtt tgatgcatat ccagcagatt 2495161 ttctaacgtt tttttcatat cgtcgcgatg aataaccgca tcaagctgtc catgttttaa 2495221 taaaaactca gccgtttgga agtcctcagg cagtttttct cctattgtct gttcaataat 2495281 ccgtcttccg gcaaaaccga tcagcgcgcc aggctcagcg aaattgtaat cgccaaggga 2495341 tgcaaagctt gctgatacgc ccccggtagt cggatgcgtc attactgaaa taataagacc 2495401 ctgttcttca ctgaacagtt ttaacgcaga gcttgtcttt gccatctgca tcaaacttaa 2495461 tacgccttcc tgcattctag caccgcctga agccgtaaaa ataataaacg gaactttatc 2495521 agcttttgct ttttcaatcg caagcgtgat tttttcaccg acgactgaac ccatgctgcc 2495581 cattctgaat gaagagtcca tgacggcgac aacagccggg tgtccgccga tggtgccctt 2495641 gcctgtcaca acagcctcgt ttaaggatgt tttctcgcga tctttttcaa gcttttccag 2495701 atatcccggg aaaccaagcg gattttccga gagcattccc tgattaaatt cctcaaagga 2495761 ttgttcatcc atcaagcttt cgatacgctg ttttgcgttc attgggaaat gataatcgca 2495821 gttcatgcat acccgcatat ttttatccaa ctctttagtg agcatgattt ttttacactt 2495881 aggacatttt gtcataatgc cttccggaac atcgtgcttc gcttgatcag acggtacgga 2495941 agcatacttt ttctttttcg tgaatatatc ctttaacaaa tgattacctc ccttttgtga 2496001 agggttctct tcaccgcatg tcatcaaaca gatagacttg ctaataactt taccgaaact 2496061 attgtacttt ttttgtcaaa cgctgtcatc ctcaattcga caacttttta ttcgatgacg 2496121 tgctcggaaa ggcttgtatg aaatcagata aggtgttgaa acgacaaggt tgacagcgca 2496181 ttcaaaaata atgttaaacc cggctgaaat ttttttaagg ctaaccccct aaaaaaattt 2496241 cagccgtcag tttaacttga gaacagcgcg ccggtctccg ccaacgcgct gccatttttg 2496301 gaatgaatta aaattattca ccaataatcg taagttttct tgttttttct gcgacttcct 2496361 cagggtcaac agtgattctt gcaacacctg tttccatcgc agcttttgcc acagccttcg 2496421 caacagcagg cgcaacacgt ttatcaaacg gtgcagggat gacatagtct gcgctaagct 2496481 catcttctga aaccagtgaa gcaatggctt caaccgctgc gattttcatt tcctcgttaa 2496541 tatgagtggc acgcacatca agcgctccgc ggaaaatacc agggaatgca agaacattgt 2496601 ttacttggtt cgggaagtca gaacggccag ttccgacaac gcttgctccg gcttcacgcg 2496661 catcttccgg catgatttcc ggatttggat ttgccattgc aaagataatc ggatcttttg 2496721 ccatgctttg aaccatttct tttgttaacg cgcctgctac agagacaccg ataaatacgt 2496781 cagcatcaac gataacatct ttcagagaac cgtctttgcg atcttggttc gtgaacttcg 2496841 ccacttcatt tttgacatcg ttcatgccgt tcgggcgccc ttcataaatg gcccctttgg 2496901 aatcgcacat cacaatgtcg cgaacgccat aatgatgaag aagcttgata atcgcaatgc 2496961 cagccgcacc cgcgccgttt gcgacaactt taatggatga catggatttt ccagacagtt 2497021 tcagcgcgtt cacaagacct gctacggtta caatggcagt accgtgctga tcatcatgga 2497081 aaaccgggat gtttgtttct tttttgaggc gctcttcaat gataaagcag tttggcgctg 2497141 caatatcttc aaggttgacg ccgccaaatg tcggttccag caattttaca gtttcaacga 2497201 ttttatcaac atcgtttgtg tttaaagcaa tcgggaacgc atctacgccc gcaaagcttt 2497261 tgaaaagaac tgctttccct tccataacag gaagcgccgc ttcagggccg atgtttccaa 2497321 ggccaagcac agctgtaccg tcagttacaa ctgctaccat gttccccttc attgtataat 2497381 catatacttt gttaatgtct tcatgaatat ccttacacgg ttctgcaaca cccggagaat 2497441 acgcgaggct taaatctttc gcatttctga cctctacttt tgatttagac tccagtttcc 2497501 cctggttgac tttatgcagg tgtaatgctt cttctcttaa tgacattctc ctaaacactc 2497561 cttatggata ttttttgatt cgtatactgc tgcgttgatt gctgcattct gcggagtaaa 2497621 tctatctgaa tatttaaaca ggatcacata attgctccaa ttgtataaca aaaagcgaat 2497681 cgttaccact gttttaaaac gacgtttttt tgacccaaca gctcttttaa gcgatataac 2497741 acctggtgat ctgcattgat atggaacgac tcaggtagct taatcgtctg tttttgcctt 2497801 tcataataga gataaacgcc tgtttcccct ttatgctcca gcaaaatgcg cttaatcttt 2497861 gccaggatct cctggctgtg ctgactgctt tctattttta tataaaccga tggcgctttt 2497921 tctgcatcca tatcttctaa taattctgcc cgggacatga tgaattggat cttatcttgt 2497981 ctaacttcac atttccccgc agtgaacaaa agagcgcctt ctcttaaaac gggagaaagc 2498041 tgtctgaatt gttcagggaa gactacggct tccatctcgc cggtttcatc actgagcgtt 2498101 aaaaacgcca tgttttgacc tgttttcgtc cgaatcgttt tgatcttcga cagcagaacg 2498161 cctagtgaaa gctgcctttt gactgcccgc tgagcctgca gaatggagac tgctccttgc 2498221 gcagtgagct gttttcggaa ggcggagagg ggatgatttg aaaaataaat gccaagcgtt 2498281 tccttttcaa acgcaagtaa atccaccaga ggaagctcct ccgtctccac atacttcggc 2498341 ttaattgaaa acgattcatc taaaaacaat cccatttggt catcgtccgc ggcgaatagc 2498401 tcagcatgtt ccaaagcaac atcaatggat gcgagcagcg tggcccggtt ttggccgaat 2498461 tcgtccatcg caccagaaaa gataagtgct tcaagcattt tgcgatttac gctttttgac 2498521 ggcacgcgaa agcagaaatc gaaaagatct tcaaatggtt tctcttttct tgctttatat 2498581 atatctttga ctgctgagac gcctacactt tttatcgcgc ggaggctgta tctgacagat 2498641 ccgttttcaa ctgtaaacgg aaaactgctt ttattcactg acggaggaag gatacgaatc 2498701 ccgctcccct ttgcttcgta aagatattga gagattttat cctcattgcc aatgacgctt 2498761 gtcagcaatc cgcacataaa atataacgga taatgagctt tcaaatacgc aagctggcac 2498821 ccgatcatgc tgtatgccac cgcatggctt ctgttaaagc catagtttgc gaatttgacg 2498881 attaaatcgt agacctcatt tgcagtgtct acagaatact ccttttttaa gcacccttca 2498941 acaaaatggc ttcgctctct gtccaggatt tcttttttct ttttgctgac cgcccttctc 2499001 aataggtccg cttcgcctaa agaaaacccc gccatacggg aagcaatcat cataatttgt 2499061 tcctgataca caatgacgcc atatgtatct tccaaaatgc tccttaaatc ttcatgagga 2499121 tagtgaacag gcgcccgacc gtgtttacgg tcgataaata acggaatatt ttccatcgga 2499181 cccggccggt acagtgcatt gaccgccaca atatcttcta ggcccgaagg tttcagccgt 2499241 ttcaagacgc ttctcatccc tgcagattca agctggaaaa tgcctgtcgt atcccctttt 2499301 gacagcaagg agaacgtttt gtcatcgctg taggaaatac ttgaaaggtc tattttaata 2499361 ttttcttctt tttcaatcat tgaagtgatg gattcaataa gtgtcagatt cctcaaacct 2499421 aagaaatcca tttttaaaag gcccaagtct tcaagatggt ccatcgcgta ttgcgttaaa 2499481 tagatccctt catgcccttc ttgaagcgga acaacatctg ttaacggttc ttcactcagg 2499541 acaacgcccg ctgcgtgggt tgatgcatgc cttggcagcc cttctatttt ccgggcaatt 2499601 gaatagactt gctgaagcag gcttgactcc cgaagccgct tatccagctg cggtgactgc 2499661 tgtctcgctt catccagcgt cattcccggt cttgaaggaa tgagttttgc aagctgatct 2499721 gcctccttcg ggctgacgcc gaatactctg ccgacgtccc ggagcgccgc ctttgccgca 2499781 agtgttccaa aggtgataat ctgtgcgacg tgcattgcac cgtatttctg ctgaacatat 2499841 tgaatgactt catcccttct agtatcggga aagtcaatat caatatccgg catgctgacg 2499901 cgttcgggat ttaaaaatct ttcaaacaga aggtgatgct taatcgggtc aacatctgtg 2499961 atatacagca catatgccac aagagaaccc gccgcagaac cccttcccgg tcctgtaaca 2500021 atcccttttt catgggcgtg cttcataaaa tcccacacga tcagaaagta atcgctgaac 2500081 ttcatccgct tgatgacatc aagctcatat tgaagacggc gaaggtatcg ttcatcaggc 2500141 ttgccgaaac ggctgcggag tccctccata cagatatccg ttaaataatc atcagcggac 2500201 gttccgtctg gggtcggaaa agacggtaga cgggtctgcc cgagactgac gtcaacccgg 2500261 cattgttccg cgatctctac agaagcttgc agtgcctcgg gatgctctcg ataaatgttt 2500321 tgcatttctt cgagtggttt caaatcgaga tcaggcaaat cttcagcggg tgcatccgtc 2500381 agtttttccc ccgctttaat cgctttcaaa caacggtagg cagccttatc ttccttcctt 2500441 atgtaatgca catcgcctgt ggccgtaaca gggatacccg tttcttctga cagctttaga 2500501 atctgctcag acaagacttg attcccttta aaaggctgat aggagaaata aaaagctccc 2500561 tttccgaata tagactgaaa ttccagcgag gcttgagcag cctgttcgaa cagccctcct 2500621 tcaagaagcg tttcaatata tcctttttcg ccgggcgtta ttgcgataat cccttctcga 2500681 taactgtgaa gccatttcgg cttcagtccg ccttttgatt tagattgcag aacgctgctg 2500741 attttcagca ggttttgata gcctgtattc gattttgcca gcaggacgag cgggtatgct 2500801 tcaagctcgc tgtcatctgt aaaaacagaa gccgtcaaac cgattattgg gttgatccct 2500861 ctcgccttgc aagctttata aaattgaata gctccgtaca tgacatgatc atctgtcagc 2500921 gccaaagacg catatccgag cctgtcagct tcactgacga gttcttccac agccgcggcg 2500981 ctgtttagca ggctataccc gctatgcact tgcaggtgaa caaaagacat gctatcacct 2501041 ctttctcatt acgatccatt tcttccttca ttataaggcc ggtttccaaa agaaacaaat 2501101 gttctttttt gactcatcat catacttgtc ctgaaagctc aatatgatat aaaaggtgag 2501161 gtgataaaga tggatcagga agcaggattt atggtgaatt ttatcaatag ctacttcatt 2501221 gcgttagggg tgctgatcgg gggcgcactc atcggagggc tcggagcata cttggcaggc 2501281 gaacccccgc ttacagccat tacaaagctt gccaaccggt taaaaatatg ggcgcttgtc 2501341 gcagctatcg gaggcacctt tgatgcggta tacagctttg aacgcggcat actcgaaggc 2501401 aatacgagag atatctttaa acagcttctt ttaattattt cggccatggg gggcgcgcaa 2501461 agcggctggc ttattatatc atggctgacc caggagcatc tttcttcatg agggtccccc 2501521 agcattacaa aaaaccggga tggcagcgtt ttttcgcggg aatgatgtgc ggagccgtaa 2501581 tcagctggtt ctttttcctg tttacttacg gaacattcca agaggagcag gtcagcctca 2501641 tcgaaaagca aaaagagcat gtaaaagact tgaacaatca aatttcgatc tatcaggaag 2501701 acctccataa actgaatgaa gataataaaa gaaaactgct gattcaaagc gtcagcgtca 2501761 aattgctgaa tggggataaa tataaaatat cacagccgga taaaacgaaa ttcgaggagc 2501821 atgtaaagga tgatatttca gaggtgatta caaaagacat agagagcgtc tatcaaacaa 2501881 aggatctctt gaagcggaca attgaaaata aagtctatat gatcaatgaa aaaaaatacg 2501941 aggcaaccgt cagagaattg attatttata cgaggctgac agtggaactt gaaatttctt 2502001 tcgccacata attatggatt ttttttaaat tctccaaact tctgtcgctt tttcccattc 2502061 ttttttataa actatatgtg aggcttaatg gcgaaaggaa ggaggaaggg aaatggaggt 2502121 ttacagtgac cgtcagttag caaaagatca agcagcccgt ctcagacaag gtttttctgc 2502181 atatgccgaa acaaactcac tcgcttccct catcaaaaaa gaacttcaat cacacaatct 2502241 ccaagtctac gaggacctta ctgatttcgg ctgctggttc atccccgtca cagatgaaca 2502301 ctaagagaga gggtctcccc tctactcgtg ttctttacat aatgtttcca gatcagctaa 2502361 aatacgatca gcttcatccc agctgtaaat agaggcgcct gaagctaacg gatgccctcc 2502421 gccgttatat ttccgggcaa gtccgttaat gacaggcccc ttcgaacgga atctgactct 2502481 gatttgatcg tcttcttcta cgaaaaacac ccaggcgcga atacctgaga tattgccaag 2502541 cgtcccgaca agctgcgacg cttcagaagc cgttgtgccg aatttttcaa gcgtatcctt 2502601 tttgatgaaa acagaagccg ccccgttttc ggacaaagac acattttgaa agataaagcc 2502661 gttaagcttc accacattca gttttgtttc atacaattga ttaaataact ctgaggaaga 2502721 gaatggatac tgaatgagct cgcctgcata ttttagtgtt ttttccgtgg tattcggaaa 2502781 taaaaagcgt ccggtatctc caacaatgcc ggcgtagatc agctctgccg ctttcgtatt 2502841 cagcttccag ccgtgctctt ttccttctaa atacagctcg taaatcattt cacttactga 2502901 gctggcgctt gtatcgaccc agagaaggtc accgtatgga tcttcgttcg gatggtggtc 2502961 gattttcatt agtttggcgc ctgaaggata acgctgatcg tcgattcttt cctgatttgc 2503021 cgtatcgcag acaatgacaa gtgcgccttc atatgtttca ttgtccacct catcaaggga 2503081 atataagaaa gagagggacg gttcaggcgt gccgaccgca aaaatatttt tttcaggata 2503141 tgtttcacgc aggatttccg taagcccaca ctgtgatccg taggcatccg gatcaggacg 2503201 cacatgtcta tgtaagataa tcgtgtcata taatgatatg gttctgatca attctgtttt 2503261 catttgatac tcctttattg tttttattca ttaaatcaca ttctctgccg acggaaaaga 2503321 aaaataacgt caaaaccaag cccgtttttg tataaaatgg ggttgtaaac ttttacgatg 2503381 gaggatttca tttatgctgg ttcttgtttt tttgattggg ctttcagcct gcttttatgt 2503441 gtactataaa gtaaaaggcg tacgggcaaa gccatctttg gcaaaagaaa tatgttcagc 2503501 aaaatcaagc atggccttag ggtcactagt cctgttctac gggcttaacc aaatgatatt 2503561 attccattca gtattaacgt tagtaatcgg cggtatcttt atcgtcatag gagcaggaag 2503621 cgcttgggca ggttataaag ccttcaggca ttacaatccc cttcacgcca aagaagctga 2503681 aagagatcac gcgtaagggg cgcctgaacg tcccttagct tctttccatc agctgaacca 2503741 tcagcatcgc tttagacacg atatgacctt ggctgtgcac ttccacttcc attttcccaa 2503801 actttctgcc ggcctccaag atgcgaggtt tgacttcgat gactgattcc atctgcacag 2503861 gcttcaaaaa gaagatggtg atgctctcta tgacgagttc gccgcgtttt ttcgagcgca 2503921 aaaatcggtt tgccgcttgc gtcaaaatgg tcgtaaatac gccataagaa atggttccaa 2503981 gctgatttgt catttgcggc gtgacttcat actcgtaaac cgtttgatct tctttatcat 2504041 caccctcatc tttaaacccc cttgaaacga tatcatcaag cttctccccg acctgcggct 2504101 gcttttgaat catttgaaga gctttcaata cgtcttggcg gctgatcatg ccgatgagtt 2504161 tttggtggcc gtcagtgacg ggaagcactt cgatcccttc ccataccatc atttgcgcag 2504221 ctgaagcgac agatgttttc ccaataaccg tgacgggatt tttggtcatg actttttcta 2504281 tagatgcatt tcggtcatgg ccagcaatat cttttgatgt cagaatgcca tggattttca 2504341 tttgatcgtc gacaaccggg aagcggccgt gccccgtttc aaaatttttc tcataccatt 2504401 tttcaagttt atccttaggc gaaagatata ccgtgcggtc agcaggtgtt aggatgtcct 2504461 ccaccaaaac aatttctttt ttgatcagct ggtcatatat tgcccggtta atcatcgcgg 2504521 caactgtaaa ggtgtcatag ctcgtggata aaatcggcag ttcaagctca tctgccagct 2504581 gcacaatgct gtcatccgtg ttaaagcccc cggtcaccaa tacggccgcg cccgcttcaa 2504641 gcgcctgcct gtgtgcattg attctgtttc cgacaatcaa aagattcccc gctgcggtgt 2504701 aacgcatcat cgcgtcaagc tccatcgcgc cgatgacgaa tttattcaat gtcttatgga 2504761 gccctgccct gcctccgagc acttgtccgt ctataacatt tacaacctct gcataggtaa 2504821 gcttttcaat gttctctttt ttcttttgtt caattctgat tgtgcccaca cgttcaatcg 2504881 tgctgacaaa ccctttattc tctgcttcct tgatcgctct gtacgcggtt ccttcgctta 2504941 ctttcatttc ctttgcaatt cttcggacag aaattttttc accgacaggc agtgaatcga 2505001 tatacgttaa aatttgttca tgcttcgttg ccaagccttt cacctctaag gacagtcttc 2505061 ttgtttttat tataaggttt caaaggattt atacgcaatg aggctggaaa ataaaaaaga 2505121 agcccgaccg gcttcttaca gcgttgattt cgttccagtc aaacgcaagg accacgtgat 2505181 tccttttaca tcgtaaagcg gaaaaacctt tatttttctt ttaaatggac atcaaccgct 2505241 gtcttaacaa tatttcgatt ccctatttta gataaaacaa ataaaactgc ggatagccat 2505301 atcgccccta tggccgtata gatcaatgga tgaacagctg tgtttgcgat ccattcattt 2505361 attaatgttc tggcatttac cagaataata aatcctccta caagcacacc catcaattgc 2505421 ggatgaaact tctgcaccag ccatgctgcg ataggggcag cgataattcc gccggccatt 2505481 agtgaaaaca cccataacca attgacgtcc tcccatccta atgaaataag aaaaccggcg 2505541 gttgcagata cggcgatggc aaattcactt gtgtctacag tcccgacaac tttcctcggg 2505601 ctcaagcctt tgcgggataa taaaatcgga gtggtcaccg gtccccagcc gcctccgcct 2505661 gtggcatctg caaaaccagc gatcactccc aatgggatgg attgttttcg gtttaacggc 2505721 acatgcttct tctcaagagc cggcttatat tgaaataaaa acctgatcaa tacatatccg 2505781 cccagaagga gcaaaaacaa agaaatatag ggtttcgcca catctccagg taattggctg 2505841 aggaatgccg cgcctaaaaa agcgcctata gagccgggaa tgacaagctg ataaacggtt 2505901 tgtttgtcaa cattgccaaa tttaatatgc gacactcccg atgcggcagt cgttacgact 2505961 tccgctaaat ggacagaagc cgaagccaca gcaggtgtga tgccaaacgc caataacaaa 2506021 gaagttgagg taaccccata agccatacct aacgaaccgt ctattaactg cgacaataaa 2506081 ccaataaatg caaaaacgat taatttcttc atcagaacac cccatctata tcaatcagat 2506141 atttttgact cttcattcga atctaacaat ctcttggcgc tttcatataa aaaataagag 2506201 gctttgataa ttgcagtttc atctattgta aatgcagggt ggtgccaatc atgatcaccg 2506261 tctgttccaa aaaacgcaaa ggatcccgga atatgctcaa gataataagc aaaatcttcc 2506321 cccgcggttg atggggcggg atcaatgact tgaagtttcg ctttatgtgc agcgtctcgc 2506381 accagccccg taattgcctc atcattacaa agcggcggcg gtccggaatg ccacttcaca 2506441 tttgccttta acgagaaagc ggcagaaatc tgctctgtga ctgcaaaaaa acgctgtttc 2506501 acttgattac gaacctctga atcaaatgta cgaacagtgc cctcaatgac cactgtatcc 2506561 ggaatgacat tccaagtgct gccgccgttg attttcccta cggttaaaat cgcgctttgc 2506621 agcgggttta catttctgct tacaatcgtt tgcagggcga caataagctg agaggcgccg 2506681 ataattggat caaaaccatt atgcggcaat gctgcatgag cacctttccc ttctatctct 2506741 actttaaatc ggtcaacagc agccataagc gggcctgttt ttaaccctac agtcccaacc 2506801 gcgatatccg gtttattgtg aaggccaata accgcatcaa tgccatccag ttggccgtcc 2506861 tctatcactt ttgtagcgcc tgcacccgct tcctctgctg gctgaaataa taaacgaatc 2506921 tttcctttca gactgtcttg attttccttc aataaaaagg ccgcaccaag aagcgctgcc 2506981 gtatgaaaat catgaccgca cgcatgcatg atccctttat gtttagacgc ataaggcaat 2507041 cctgtttttt cttcaattgg caaggcgtca atatcagccc tcaaagcaat cgccggacct 2507101 tctgactccc ctgctatgtc tgcgaacaca cccgttttta gagcagtagg gcgaatctgt 2507161 atcccctttt ctttaaggca tttttttata aaagcagttg tttcaaattc ttcttttgac 2507221 agttcaggat attggtgcag gtgccggcga atgccgatga gctgcttttc tagcgttgag 2507281 agatttacgg gattagactc ctctttcaac gtcaggatgt catttcctgt agtctgatat 2507341 ggataggagc cttctatatt tctccaataa tccaaagaca tatgttccgc tcctttccct 2507401 atcccaatat attttcttca gactcttcaa cataagatga aataaatcgg ttcaatttat 2507461 cagcaagacc gcccgcccca aatcttatat acttgctgga aactttcgga ttatcttctt 2507521 tcaaaaagct taaaaaagat aaaatataaa tgcgcctgta agctacttgt gtaattccgt 2507581 actcaaaaaa ccagttatca atgacattgt atacgcctcg gttgacgcca tataggttat 2507641 tacatttctt gtaaaagcag agatccggaa gatttaactc ctgatgggaa agaaggcttt 2507701 cttttttgtt tggtgccata atcccaatca gctcaaagcg ttttgcaacg cacgaaatat 2507761 cctttttaat ttgctttgtt aaagactcca aagaatcaaa ccttctttct tctctaattt 2507821 taaagagaat gctgcattcg attttttctc cataaatgtc tctatgaaag tcaaacaaaa 2507881 aaatctccaa tgtcttttca aggttagagc ccaccgtcgg tttcacaccg atattcataa 2507941 cccctaaatg aaattgatga ttgactgtcg ccagaacccc ataaactcca ttacgcagcc 2508001 catgtatttt tgcatctaca tttgccgtgg ggaatccaag ctttctgcct aattgttttc 2508061 ctttcacaac cgtaccggca atgatcgtca aaaaagtcag cctcctctct cagcttccgc 2508121 attcgatcag acgaaaccta atgatgtgat gaatgtaaaa cggattgatg ctgcggaatg 2508181 ccaagaccga gattttcccg caatgtcccg ccgcgataat cttgacgata aagccctctt 2508241 tcttgaagaa tcggaatcac cttttctaca aaagcatcaa gtgttcccgg tatatccgac 2508301 ccaacgataa acccatccgc cgcctcagcg ttgaaccaag tttcaattaa ggatgcgaca 2508361 cgctctggtg ttccgatgaa tagagtccgt ggaaaagcca tttcctgtgc tacctcccgc 2508421 aatgtcagat ttctggcttt tgcttctctc ttaatccggt ctgttgtgct ttgaaacgca 2508481 ttctttccca catcgccaat atcgggaaat ggctcatcca acgggtaaac actcagatca 2508541 taatcatcaa aaaaacgggc caaataagta acagcatttt caatcggtat caattctgca 2508601 aattcacgat acttcttttc cgcctcttct tccgtatctg ccacaatcgg gctgatccct 2508661 ggaaaaatcc gcacacttga aggatcacgc ccttcatcag cagctcggct tttcacatcc 2508721 gcataaaacg cttttgtctc ttctaatgaa ttggaatggg taaaaatcgc atccgcattt 2508781 ttagcagcaa actgccggcc tgtttctgat gaacccgctt gaaacactac aggctctccc 2508841 tgcttagagc gcccgatatt caagggcccc tctacttgaa aatactttcc tttatgattc 2508901 aggcgatgaa gcttcgcctg atcgaaaaac tgccctgttt tcttattgtg tataaatgcg 2508961 tcatgctccc aggaattcca cagcccgcgc acaacatcca aatgctcttg tgcgatctcg 2509021 taacgttcag tgtgttctgg caaattagac ttactatggt tgcgcgccgc tccttcctgc 2509081 ggcgaagtaa ccagattcca gccggccctg cccccgctga tatggtccag cgacatcaat 2509141 tgtctggaga tagtgaatgg ctcagtaaaa gatgtagaga acgtccctac taaaccaata 2509201 tttttggtaa ccgatgccag cgcagataaa atggtgatcg gttcaaaacg gtttaaaaaa 2509261 tgaggaatcg atttttcaga aataaataag ccgtctgcaa tgaaaataaa actaaacaaa 2509321 cctttttcag ctgtttgcgc ctttttcatg taaaattcaa tattcgtgct ggccgaggga 2509381 tcaacatcgg gatgacgcca gccgtcagtt gttcccccga caccgtgaat catggctcca 2509441 aactgaataa aatctgcacg tgtcatcttt ttgcctcctt tatctgtgca tgattagcaa 2509501 gtgcaagatc aaggtgttca atgccgattt cagttatccc ttgatactga ttgccgcgcc 2509561 cgatttcgac cacaggcaca tggcgcaccc catatttcac ctgtaaaata tcccgaagct 2509621 tttctttctc tgaaacatcg atattttgga acgggaaccc tttttcattc aaataattct 2509681 tgacttcctc acaatacgaa cagccttttt tactccaaac cacaatgttc acaacatcac 2509741 tcattcttct gtccctcctt aacgttttgc agctaaaact gcatcgctca gcagctgata 2509801 agacagctgt ttttctacag catttttgat cggtgtaaaa ataacaaaat cattgatttt 2509861 gtatgtgcct gataaacgtg ttaattcttc tgccacttct tcctttgttc cggcaataat 2509921 cccggttttt tgcacgatga tgtcataggg ctctgtgacg ttttccagat aggcctcagc 2509981 ctgttcgcgg gaaccgacgt tgaccttacg cccgtctttc aaaaccactt ttatcgattc 2510041 acgcgacaca atatgttttt ccgcttcttc ttttgtatgt gccgcaaaaa cagcgggggc 2510101 aagatgaaat tcagcctcag atcctggcgg gagatgcgcg tcaaatgctc ggcgggcttc 2510161 cttcagcact tcctcttcac cgttaataaa gtaagcaaag acaaaagaga ttcccagttt 2510221 tgcagcagaa atggcactct ctgtgcttcc tcccaataga aaaatacccg gcttccgatc 2510281 aacctgcggc ctaggacgca atgcggcata gcggtgggta tcaggaaaat catcccgaac 2510341 gaaatgagta agctcctcca gtttttcatc aaactgacgc accggttttt tatattcggc 2510401 ctgcagcgcg tctgtggaca gctgaaaccc gccgggcgct ttgcccactc caagatctat 2510461 acggccggga gctaacgctg atagaagatg gaattgctcc gctactttat aagagctgta 2510521 atgctgcagc atcactccgc ctgatgctaa acgaattttt cttgtgcttg cagcaagata 2510581 gcctaaaaga acctcgggtg cagaccctgc aatctcatca ttgttgtgat gttcggccac 2510641 ccaaaatcgg tgatatccac attcttcagc catttgtgcc aatttcactg tatgctgtaa 2510701 tgtatcagct gctgtctccc cttcaccaat caagctttgg tctaaaatac ttaagcggat 2510761 catatcaccg gctcctttat gtgttctttt ggttcaaata aatattccgg cgaaacacgg 2510821 cggagaaact gcctcgttct gtcttttttg gtatggcgga agacttcctc cggggttcct 2510881 tgttcaacaa tgactccttc atccataaaa acaacttgat cagagaccct tcttgcaaac 2510941 tccatttcat gtgtaacaac aatcatggtg gctccggttt tcacgatttc cagcattacc 2511001 tcaagcactt caccgaccag ctccgggtca agcgctgccg tcggctcatc gaacagcagc 2511061 acatcaggat gaatggcaag cgcccttgct atccctaccc tctgcttttg tcctcccgat 2511121 aactgactcg gataagcgtt caatttatct tgaagcccga cctttctcag ttcattttcc 2511181 gctacggcat acgcgtcttg ttttctcatt ttccgggcaa tcgtcaagcc ctccatgaca 2511241 ttttcaatca ccgttttgtg agcaaacagg tggtattgct gaaataccat tgccgtctgt 2511301 tttctgagcc agtgaacctc ttttttggac ggaaagcggc aattaatcac tttgtcatgt 2511361 atagaaatga tcccttcgtc tggacgttct aataaattca ggcaccgtaa aaaggtggtt 2511421 ttccctgatc cgctcggccc gataatcgtc acaacttctc ccttgcgtac cgtgagattt 2511481 atccctttta atacatggtg gatgccaaac tgtttatgga tatttttaat ctcaatcata 2511541 aagtgcctcc ttgaaatctg gctgcctttc tctctaatac tccatttgcg gattctagga 2511601 ttagagtcag cacccaatag ataatcgctg ctccgataaa cgcttctaaa aatgcataat 2511661 tatcagaagc aacgatagtc gccgtccctg taatctctgg gacagccact atagccgcga 2511721 tagaggtggt atgcaaaaag ccgataccca aatttgtgaa gtttgggatg gaaaccttca 2511781 gcgcctgcgg caatattaca cgccgaaagg tttggctgta tgtcaagccg attgaataag 2511841 ccgcttcgac ctgtccggta tccatcgcca gaatgcccga ccggatgatt tctgtgagat 2511901 aagctccggc agttaaagac aaggccatga tgacaaacat ggagaccggt atctcattag 2511961 cggaccagcc gagatgaaaa aaactgctga cttgatctgc aacaggcggt atccctaaat 2512021 aaatcaacat aatgtgaaga attgcaggtg tacttcgaaa gaaagacaca taaaaccttg 2512081 agcaagccac caagccctta attctaaaaa ttctaacaat tatatttcca agagccacga 2512141 gaaatccaaa cacaatcggc aaaacagcca tcatcaatgt cagaggaatg gtctttacca 2512201 tttctttcat ggcggaaacg ataaatggaa agtcaaattg caatcttctc ccccctcatc 2512261 cgaagaaata tatcaatgta tgttcatgtc aaaaacagta acaatccttg tttgattctt 2512321 cttgattcgt ttttctgcca ctcgaaagaa ccattcgaat aaaaccgcta cagcataata 2512381 aacaatcgat agcgcaatgt aaacttcaag agaatggttg cttgaggtaa tcagtgtttg 2512441 gccccttccg gacatatcca taacacctat tgaaaaggct agagacgtat cttttaaaga 2512501 actgatcacc atgtttccca tattcggaaa cgcctggaca agtgcctggg gcagaacgat 2512561 tcgcctgaag gcctgactac cgcttaagcc aatactgtac gccgcttccg tttggccttt 2512621 atctacactg cccacccccg ctcgaatgat ttctgcggct gccgctgcat tgcttaacgc 2512681 gtaggttgcg acagcagcat aaaacgggtc catttttgat gtatcaatcc cgataagccc 2512741 cgtaagcgcc gggatcccgt aaaacacgat gaaaagctgc accatgatag gcgttcccct 2512801 gaaaaacgag atatacactt ttgccaattg atttacaatt ggaatattat agatgcgggg 2512861 cagtgccaga aagagtccta atacaaaacc gaaaagcaag gacagtgtta aaatgtataa 2512921 tgtaaccggt aaataagcgg ttaacgtcgg cacaaaatct ccaatcatgt tcatatcaaa 2512981 cgctttttcc atcactgctc cctctctttt tacctaatac tgctctttgg aatagtcgtc 2513041 accaagccat ttcaaactga gccttttcaa cgttccgtca tcaatgattt cctgtaaggc 2513101 tttatcaata tcgtcactta acgtttgttc atttttgtta aacataaaat acactttggc 2513161 atttgaaagc acattaccga cggttttttc tttaatagtg ctcgtcttgt tttgaaagtc 2513221 tactgcaaaa ggcgttgaga tcgttgcgtc cgcacgcccc gatttcagct gattcgcagt 2513281 ctcatttgcg ccttggccct cataggcaat ctcaaacggc cgtccattat cctcattcca 2513341 ttttttcagt acaagcgctc cgttggaggt tgcactcgta atcacccgtt ttccttttaa 2513401 gtcttcaatt ccacggatcg tatcgttatt ttgaagcaca gtaattttta aaggaaaatg 2513461 gttgtaagca accttgttaa acagaaattt tttctcacgc tctttgcttt tctccatttg 2513521 atgtgccacg atatcgactt tatgctgtcc gaggctgaca agcaggttgg aaaattccat 2513581 cgttttaaat gtgaatttat aatgtggcag gcgcttatca agctctttga tcagttcgac 2513641 atcataaccg gttaaatcgc ctttttcatc gataaagcaa atattcggaa attgggttcc 2513701 agttccgacc gtgatcgtct gtaccttctt ttgcccggct cccgtcgttt gactgcctgc 2513761 accgcaagct gacagaactg ttataagcga aaataatatt gccatgaatg ctgttttcgt 2513821 tttcatctca tcgccccatt tatttttcaa aacttgattt tgaataatct gccccgagcc 2513881 attttcggct tagttttttt agcgttccgt ttttctccag ctttttaatc gcttgatccg 2513941 tgtcatccgc caaggtttgg ctgcctttat taaacataaa gtacacctcg gtatctaata 2514001 acacgtcacc gactgtcttt tggcggaagg cgtgcgtttt attctgaaaa tcgacggcaa 2514061 acggtgtagc tatcgttgca tctgcgcgcc cggtttcaat ttgattggcg gtatcattgc 2514121 ttccctgtcc cgcatatttc aaatgaattg ggctgccgtg cgttttgttg tactttgtaa 2514181 tataatctgc cgcatttgac gtggcgccaa ctatgactgt ttttccgtgt aagtctttta 2514241 atgtatgaat cttgtgatta tcctctttca ccgtgatgta catcggcgag tagttatatg 2514301 ggactttatg atacaaaaaa cgcttttctc gttctttatt tttggccata ttgtgcgcaa 2514361 tcacatcaat ttttttattt ccgagactcg tcagcaaatt tgagaaatcc atcgttttaa 2514421 attcaaatgt atattgaggc aactccttat cgatggcttt catcacttca atgtcatacc 2514481 cggtcaattc acctttttca tttaaaaacg caatattcgg aaaatctgtt ccagtgccga 2514541 ctatgaccgt ttgagcctga cgatctgttt tgttatttgt ttgcgaacat cccccgccaa 2514601 gtaatgcaaa cactgacagc agcaaaacca atcctttacg cttattcata ggctgcctca 2514661 catcatgccc agctgggcgc acctaaaagc gttgggttaa atcgttccgg aatcagaacc 2514721 ttgtgcatca tcacacctat gtccccgtct ttttcctgct caaaatacac ttcataccct 2514781 ctccttctgt acatgtcagc aagccaagga tgcttgcgcg ccgatgtgcc gagtgtcagc 2514841 gcaggagcct tcagcatatc tcgaagcact ttttcttcaa catacgtaag cagcttactt 2514901 ccggcgcctt gccctttata ttccggcagt gtcgcaaacc accacacaaa tggatatttt 2514961 gaaggaggcg tctcactctc ccacgggaac ctgattgtaa tcgttgaaat cagcttccca 2515021 tcccgctcca gcacaatcgc tgaatgatgt tcaatatttt ctgataccat ttggatatca 2515081 gctctcgtgg atggccaatc aatatccagc tgccgaatgg gctgaaatgc gctgttaacc 2515141 agtttcaaca gctccgatgc atcttcaaca gttgccagtc gaaaaatatc atcactcatt 2515201 tttgtcactc ctcttcacaa aatatataat tcctatttgt ttactaagct tttattgttt 2515261 atactataaa gcatactctg atctttgact aatcaaaaaa agtaaacctt cacttcagta 2515321 attttaatga tgaaaaacag gagggagcac attggagtta cgctcaatca aaacgtttca 2515381 tacgattgta aaatttggaa gcttctataa agctgcagaa atactcaact actcgcagcc 2515441 gacgatatcg atgcgtatga agcaattgga gcaggattta ggcgtactgc tgtttgaaag 2515501 aggaaaaagc ctgcagttga caaaagcagg gaagcttttt tatgaacgaa caggagatct 2515561 tttgatgcaa tacgaggcgc ttaaacacaa cctctccgac ttaaaggaag aagaggcagg 2515621 cattatcaac ataggggttt cagagccaac cgccagtctg atattccccg agattttaaa 2515681 ggatttctta atggattacc caaagataac ggttaatatc aaggttgatg acgccaatac 2515741 ctgcagtcaa aagctcttag acgggacgat tgattttgca gtctgcggcg agccggagct 2515801 gattcttgaa aattactacc atccattttt ttatgacaca ttaaatgtga ttgtatctga 2515861 tcaacatccg ctcgctgaga agaaggctgt ccatttgtct gatttagcag aagagcgctt 2515921 catatttacg cccgccaatt gccccattcg cttacaaatt gaacagcatt tacatagaga 2515981 actcgggaat cgctacaaaa aaatggagct cacaagcagc atgtcacatg aatattacgt 2516041 acgtgaaaac atcggaattt caatctttac cagcaccgca cattctaaac cgttcaacgg 2516101 cactaaagtc attccaattc tgaacctgga tatcaccccg cccatagggc tgttgacaaa 2516161 tcaaaaagaa gttcattttg accgcgccac gaaggacttg atcgcccgga taaccaaacg 2516221 ttttcagcag cgcagcaaag aattggaagg aacctctgat aagaccatta caggataact 2516281 gaaaaaataa aaaccacctc ctgattcatc aggagatggt ttcacggttt aaagctcgat 2516341 cgtctcaccg accgacatga ctttgccgac tccgcccggc aggctgtcag cgaatgcttc 2516401 tgggtcttgt tcgatgaccg ggaatgtatt gtaatgcacc ggcacgacct gttttgcgcg 2516461 cagccattca gcagcaagct tggcgtcttc aggccccatt gtaaagttat cgccaatcgg 2516521 aaggaaagca aggtcgatat gattcaattc gccaatgagt ttcatatcag agaaaagtgc 2516581 cgtatcgccc gcgtggaaaa tcgttttatc ttctacagtc agcaaaatac cggcaggcat 2516641 gcctgtgtaa gtgatcgttt tgttttcttc atctgtgatg gctgatccat gaaaggcctg 2516701 tgtgagcttc acttttccaa aatcgaactg gcgggagccg ccaatatgca ttggatgaac 2516761 attcaagcct ttccagccta agtacacagc gagctcgttc ggggctataa ccagcgcgtt 2516821 attttgcttg gcgatttgtt cagtatcacc gacatggtca ttgtggccgt gcgttagtaa 2516881 gatgacatcc gcttttacat cctccggctt tatatccgtt aatgaattcc ctgttaaaaa 2516941 cggatcaaaa ataatatgat ggtccttcgt ttccactgtg attacagaat gtccgtgata 2517001 tgtcactttc atttctttca cctcgtcaca tgattttgtt ttttttattt tcccttttta 2517061 aaaagctgaa aaacttatgt tgtttgattc ttgttaatga cattgaggcc tccggtggct 2517121 tcaatgacag tccctgtcac aaggtctgag ttctcctcac acaagaaagc gataatcctg 2517181 gcaatatcct cgcctgtacc ggatcttcct atcggcgttt tttctttgcc gattcgcatt 2517241 ctggcttcct ctatcgatgc ttctttcatg tcgccgacaa tgtctcctgg gcaaaccatg 2517301 ttggcggtta tgccgaattc ggcttcttca atggcaattg tcttcgtcaa agaagccaag 2517361 cccactttcg cagcgccaaa tgccgatcgg tgaagccagc cgggcgcgtg agccgcacct 2517421 tggaatccgt acgtaataat gcgtccaaat tgctgttttc tcataatagg aataaccgct 2517481 ttgaataaat gaaagacggc gcttaaattt ccttccagca tgccatacca ttcatcatca 2517541 gtataatcgg ctaacttttt acgttcaaat atgtatggtc cagcgttgtt aatcaaaaag 2517601 tcgatccttc cgaagcggtt taaggcagcc tctgcaatac gcagcagatc ttcttttttg 2517661 gtgacatcac cttttacaaa ttgcagccgg tcaagacaat cgggacaggc ttccttcagg 2517721 cggctgactg cctcctcatc ctgtctgtaa ttgactgtta ctgaataccc ctttgcaagc 2517781 aacgtttcag tcactttgcg gcctaaaccc ttcgaaccgg cagtaattaa agcatgtcgc 2517841 acatgaatac ctcccaaagc aacgtcgccg ctttcaataa agtgtttctt cttctacttt 2517901 actataaaag gcttgcaata tcacttttta cactttggca tacaaaaaaa gctgcctgta 2517961 cagacagctt attctgcagg agatgaagac tcctgatcag gcatatcgac ataaccgctt 2518021 tgatatgctt ctgaaatgag ccttgttgtc tcctggcttt cttgttcatc ataaatatag 2518081 cgttccggtt cttttttcat cattctgcct cccatcatta tagaggtagg ttggctataa 2518141 tgacgggatt ttatgaagga aattttaaca aactcctgct gccacgcaag ctttcgcttt 2518201 ttcaagcgcc tgttccacct gtttgaatcc ggtgcccccg gcgctcattc ttttttcaac 2518261 tgcgtagtaa gggtctaaca cagtgtaaat atcttcttca aatagtgtgc tcgcctgctg 2518321 aaactcgcca aacggcatat cgcttaaata gatccctctt tcgatgcatg tgtacacaag 2518381 tttcccgacc acttcatgcg cttctctgaa cggcattcct tttttagcta aataatcggc 2518441 cagttccgtc gcgtttgaaa agtcttgttt tgttgcttgc ttcatgacgt ctttgtttac 2518501 agtcattgtt tggatcatgc ctgtgaagat ttgcaggctg ccctccaccg ttttcaccgt 2518561 gtcaaacatg ccctctttgt cttcctgcag atctttgttg taagcgagcg gaagtccttt 2518621 catgatcgta aacagcccca tcatatcgcc gtatacgcgt cctgttttgc cgcggatcag 2518681 ctccgccata tcagggtttt tcttttgcgg catcatgctg cttcctgttg cgtacgtatc 2518741 gtcaagctcg atgaatttaa actcctgcga gcaccataaa atgatttctt cagagaaacg 2518801 ggataggtgc atcatcagca tactgctgtt gcttaaaaac tccaaaatga agtctctgtc 2518861 gctgacgccg tccaagctgt tttcataaat ggcatcaaag ccgagcagtt ccgctgaata 2518921 atcacggtca attgggaagg ttgttcccgc gagcgccccg cagccgagcg gagatttgtt 2518981 aatccgcttc attgaatcct gaaaacgctc cttgtcgcgc tcaagcatcc agaaatacgc 2519041 aagcagatgg tgagcgaatg aaatcggctg ggcgcgctgc aaatgtgtgt agcccggcag 2519101 aatcgtttca acgttcgctt ccgccttttc aatcagcgca ctttggaatg cctcaatcag 2519161 ctcgatgatg tggccgacat gattcttcaa gtataaatgc atgtcagtcg ccacctggtc 2519221 attccggctt ctgccggtat gcagcttgcc gccaagagga ccgatttcgt caatgagcat 2519281 tttctcaatg ttcaaatgaa tatcctcata atcgactgag aattccaatg ctccctcctc 2519341 tgctttttgc aaaagggtat tcaggccctc tcggattttc aactcttctt ctgctgtcag 2519401 aataccgcat tttttcagca tggcagcatg tgcgagagac cctgtaatgt cttcagcaac 2519461 taaattttgg tcaaatgata tggacgcgcc gaactcgtcg acccattttt ccggtgtttt 2519521 ttgaaatcgg cctccccaaa gcttcttcat gctttaatct gctccttctt tttcacgatg 2519581 ctgttcactt ttgtcggaag tccccaaagc tcgataaatc cgattgctgc atggtgatca 2519641 aatgcatcgt cttttgtata tgttgcaagt ttttcatcat atagagagta ttccgattta 2519701 cgtccttcta caattgcatg gcctttaaac agcttcacgc ggacaatgcc tgtgacatgc 2519761 ttttgcgttt cttttaagaa agcgtgcagc gcgtctttta acggtgagaa ccataagccg 2519821 ttgtaaatga tttctgacat tttttgctcg atgatcggtt taaagtgggc tacctctttc 2519881 accagtgtca aatcttctaa ttctttatgc gctttgatca gtgtcatcgc accagggcat 2519941 tcgtatactt cccgggattt aatgccgacg aggcggtttt ccacgtggtc gatacgtccg 2520001 acaccgtgcg cgcccgccat ttcattcagc ttcaagatca gctcagaaag cgagtaggaa 2520061 acaccgtcaa tggagacagg cacgccctgt tcaaatgcaa tttcaatcac ttccggcgtg 2520121 tccggcgttt tttccagcgg agctgttaaa tcgtatgcac cttctggcgg cgccgcccat 2520181 ggatcttcta aaatgccgca ctcattggcg cgtccccaga ggttttggtc gatagaatac 2520241 gggctgtcaa gattgatcgg aatcggaatg ccgcggctag ccgcatattc aatttcttct 2520301 tcacgtgacc actgccattc gcgaaccggc gcgatgactt ctaggtcagg gtttaatgat 2520361 ttaatggaga cttcgaaacg aacctggtca tttcctttcc ctgtgcatcc gtgggcaatc 2520421 gcctgtgcat cttctttttc cgcaatttca accagttttt tcgcgatcag cggtcgagat 2520481 aatgccgaaa caagcgggta ttttccttca tacattgtgt gggcctgcaa agagataagc 2520541 gcgtaatcct gtgcaaattc ttcttttgca tcgatcacgt aggagtttgt cgcgccgact 2520601 tcaagcgctt tctgctgaac aaatgccaaa tctttgccct caccgacatc caggcagcag 2520661 gcgattacat tatatccttg ctcctgaagc cattttattg cgacggaagt atcaagacct 2520721 cctgagtatg ctaatacgac ttttttctgt tctgacatga taaaaatccc ctctcaaccg 2520781 tgtttctatt ttgtataaaa ataaattata tttaataaaa atacattttg tatgtataca 2520841 ctttaacaag tacgtttcgt tttttcaagc cttttataaa aaaaacttca cctaaatttc 2520901 aggtgaagtt tcatagtatt tattcattta cttgtctttt ctgatttctc tgaccacatg 2520961 cgcaagttcg ggaataatca gcttattcat tgccagcttt actgcgccgc ttgagcctgg 2521021 cgttgagaaa acagcggtat gctgaatgac gccggcagtt gctctcgaca tgattgcggc 2521081 agagccgata tcctctgtat aactcagcat cctgaatatt tctccaaagc cgggcagttc 2521141 tttcgaaaac agcggcgtta tggcttcaat tgtgacatcc cgatctgcta tgcctgtccc 2521201 tccgtttaag agtaccgcgt ctgtctgttc atccatgcag cccgcaagca ctgaccgttg 2521261 caaagcatcc ttttcgtctt ttacaatttc atatgcggca atatgatgac cggcttcttc 2521321 taaaaatgag atcatcagct tgccgctttt atcggtttca tctgtcctcg tgtcactgac 2521381 agtaatcact ttgcaccgaa cgatatcggg agcttcttgt ttatgctctt gaacgctcat 2521441 tggcccacct cttttatgtt ttctgtctgt cactatcatg catcaacaaa aaagcacatt 2521501 caagagaatg tgctttcatg cgatttattt tgctaaacga acaacgtcgc gcgcaatcat 2521561 gacttcttca tcagtcggga tgatcatgac ttttactgga gaatgcggat agctgatgaa 2521621 agcttcctcg ccgcgcacgt tattaagcgc agggtcccag tatacgccca tgaattctaa 2521681 accgcgaaga acgcgttctc tgacttccac actgttttca ccgataccgg cagtaaagat 2521741 gatcgcatct acaccgctca ttcttgcagc gtaagaaccg atgtatttgt ggattctgct 2521801 tgcgaatact tcaagagccg tttccgcgcg ctcatttcct tctttcgtag cttcaacgat 2521861 gtcacgaaga tcgcttgaga aaccggaaat gccgagcagt ccgctttttt tgtttaatgt 2521921 attcagtact tcgtcagccg tttggcctgt tttctccatg atgtatggga tcagggcagg 2521981 gtcgatgttt ccagagcgtg tgcccattgc tacaccggca agcggcgtaa agcccatgga 2522041 tgtgtcaata gattttccgc cttcaacagc ggcaatactt gctccgtttc caaggtggca 2522101 ggaaatcagg cgcaagtctt ttaacggacg gccgagaagc tctgccgcac gctcagttac 2522161 atatttatgt gaagtgccgt ggaagccgta tttacggatg ccgaattttt catagtattc 2522221 atacggcaag ctgtaaaggt aagactgctc aggcattgtt tggtggaatg ctgtatcaaa 2522281 tacagctacc gcaggaacat ttggaagcac ttctttgaac gctttaattc caacgatatt 2522341 tgccggattg tgaagcggtg ccaattcaga aatatcttcg atttccttaa tggtttcatc 2522401 cgttaataaa acagaatcgc tgaatttttc tccgccgtga acgacacgat ggccaattcc 2522461 gtcaatttca ttcaagtctt taataatgcc gaattccgtt aacttattca gcagcatttt 2522521 aacagctacc gcatgatctg gaatatcagt tacttctgta tttttttcgc cgttcacaga 2522581 aattgtgaat acgctgtcgg cgataccgat tcgttcaact aaacccttcg ttaaaacggt 2522641 ttctgaaggc atttcgaaaa gctgaaattt caaagacgag cttcctgcgt taattgcaat 2522701 aattttggac atgattgacg ctcctttata ctctgtatca acaacttcgt ttttcgtact 2522761 tttttcccgg tgaatatcaa catcttctcc gaaaaatatc tgacttttcc atttaaacat 2522821 tgtcatgtcg gcttttcaag tcaacttgcg tattgataac gcttacaata agaagtcgtt 2522881 attttcagac acattcacta taggttttgt attgatgaac gcttacaatt tgcggttttt 2522941 ccctctgtat tttgtgtttc aaagctggat tcaattcgtc aagtccggtc ttcaaaagca 2523001 taaataaaag cagcttaggc atcgacctca tacggctgtc taagctgctt ttaaaacact 2523061 tacttttctt ttttaaacca ttcatcaaat tgagccatca tatcaagcat cgccttttga 2523121 ttggagaaag acggaagatt cgcaagcaga atttgccccg gcgctttcgt attctctcct 2523181 tgtttctgaa gcacaaggat gcttttggca tgagcttcgt ctttaaaaat agattttggc 2523241 agctgcaaca gtgcgttgat atgaacctta tctttgaaaa actgtttcag cttgccgctt 2523301 tgggagctct caaacaaatg attcggaatc ataaaaaata agtagccgcc cggtttggta 2523361 tgcttgacgc tctgttcaat aaacagatga tgagcgaagg aatggccttc gtcagctttg 2523421 agctcaaacg cttctgctcc ttcgtcattc ggataatagc cgactggcag atcacaaatg 2523481 accgtgtcaa ctggatcgat aaacaacggc tcaaggctgt cctggtggaa aagctcaagc 2523541 tcttttttca gaaggttcgc ttgggcatag gcgatcttca agagcacatc atcaatttca 2523601 atgccaaagc tgtttgccgt tttttcagac agctggttca gcacggtaaa cagaaggttc 2523661 ccagttccca gggctggatc aagaatggtc agttcctttt tgtccgccat aaatttattc 2523721 accaaatagc tgatgaaaag cccgatcgta tccggcgtca tttgtctgtt tggatgcgag 2523781 atatctttca ttcctttaag gacggcaagc tgaaaagcct tgcgtaccca ctcatgctca 2523841 tacgtgccga attccgcttt ttcaagcaga gcctgaagtt gtttggtttt ctgatcagca 2523901 ggcagtttca gctgatccgt tttttcaaga aaatacattt ctcctgcttc ggccagcgcc 2523961 tctatatatg aaatctgcaa ttcattcttt atcataatcg cggcttcgtt taacagctca 2524021 tacaccgcac ctacatggtc tttttgcata ttgtgttcct ccttgccatg aaaaaagctc 2524081 cggcggcagc ctggagcttt tttccctgct tactttacta atgccttagc agcctcaatt 2524141 ggcttttcat agttcgggtg gtttgttgct tcgcttacat attcagcgta aacgactttt 2524201 ccgttctcat caaggacaaa tacggaacgc gcaagcagac gaagttcttt aatatacaca 2524261 ccgaacgctt cgccaaatga catatctctg tggtcagaca gtgtttccac tttgtcaatt 2524321 ccgttagcgc cgcaccagcg cgcttgcgcg aatggaaggt ctgcactgat tgtgtagacg 2524381 ttgacatctc caagctttgc agcttcttcg ttaaaacggc gtgtttgtgc atcacaaaca 2524441 cctgtatcaa ttgaagggat aacagaaata atcgttacct ttcctttcat gtcagctaac 2524501 gatttttctt caaggctgtt agtcagcact gtgaaatcag gagcttgatc tcctaccttc 2524561 acttcttgtc cgacaagtgt aaccggaccg cctttgaatg taatttcagc cattataatt 2524621 cctccctttt gtatgtatgt ctctatcata gtaaagtttc ctgcaaactg caaagtttat 2524681 gccaaaaaaa agttaactgc ggccagcgca gttaaccttt ttttaataat tcatattgtt 2524741 catttggttt tgattttggc cttggctttg gtttttgtta tttttcttga acatttgctg 2524801 gatgcgctcg agtgtttgag gggctgcgtc taaaattttc tctattaaat gggtattttc 2524861 atctaaatga agcattctga tgcctgtcga tccgacaatt aaaaacgcga tcggcgtaat 2524921 ggacacaccg cccccgcttc cgcctccgaa aggaagtttc tgttctcttg tctcatcgtc 2524981 ttccgatttc ttttcggccg gctttccgcc aaactcgctt ccgcctgcgg cgaatccgaa 2525041 tccaacttta gaaacagtta aaatcacact tccatcaggc gtttccactg gatctccgat 2525101 gatggtgtta acatcaatca tttccttcaa gttttccatt gcggttttca ttaaaccttg 2525161 gatgggatgg tctgccatat acgcttcctc cttaaactga tgaatcattc tttgaagtca 2525221 ttctagccga cggattcttc tttaatacgg atagctcccg tccgtatttg acgaatttga 2525281 aagctgcaag catagcatgt ccaaagcgaa aaaagaatat acactgaaaa tgggtcttgg 2525341 aaacagggac ttgaaacgac gggatcacct catagacagg tttattcaca aagtccaggt 2525401 ggtcgtagag cattgctgcg ataccgccct tcacgcccca tacagcaccg gttaacacac 2525461 ctgtcactgc cgcgtcctga attccgatta ctgtaaccca ttctagtttt gtgatatgta 2525521 aatgcgcgag aaaagacgcg ctgattttcc gcagtctggt gacctgatgc aaaagcattt 2525581 cgattttatt aatgctttgc tgcacatcgt tttgtgtaat ttttttcttt ccgctgcttt 2525641 ttttcatttt ggattcagtt ttttgtttga tatccactgt tccgtcttct ttgttcacct 2525701 taatcgccgg gattgttttt ttgatcctta taaggccaaa cagcgccgta atcttcaagg 2525761 tcaatttgtc attatcatcg gcatgaagat actccagcgc gacatggatt ttcattctga 2525821 gaagcagtac gatccctatg agaataagaa tggctgtcag tacatacacc atattcttca 2525881 cttcctctag gagcattatc gccaattcct aaaaaaataa acccggacgg aagtccgggt 2525941 tatcggttat ttgcggtata atttttcatg caccacggtg gtatccgcga tgtaatcatg 2526001 aatcccttgt tttgtaggtg aaaaggcaac aacgatatat aaaatccaaa tcttatcaat 2526061 ataccgtcca accacttcac gaaaaatcac tgtactccat gtcagcttgc tatcttgctt 2526121 cacagaaacc actttgaggc cgaacaccat tttaccaagc gtctgcctga agtattttgt 2526181 catgagtgcg aaataggcaa gatacacaat aagcgttgtc acactgtagg ccgagaaggt 2526241 aaacatgccg gatgttttcg gcagatccaa tacggtaaag aggggagaaa cgagcaaatg 2526301 gtttaatccc catatcacga gccaatcaag caggaaagcc cagaaacgaa cccaaaagcc 2526361 agcataggca tgtgtcagca gctccgcttc ttgcgggcct ttgatgtcat tgcgctctaa 2526421 ctcttcatat gtcgcgtcca ttattgttcc ctcctacttc gcatagagat acatcattct 2526481 cggcgaaccg gattgcgata gaatttctct catattcaaa aaatcaattt cacttttaaa 2526541 cattttgttc gcgcccatgg aaaacagtga gcctaatccg aagctttcct cataagaaat 2526601 gacagaggcg tttttcaaat ccttgtgatc ctttttcatg gccgtaatgg tatcgtcata 2526661 aaaaccaagc tcatcaacga ggttcagttt tttcgcctgc cgtccgtcat acacgcggcc 2526721 gtccgcaatt ttctttacct ctgctttcgg catgccgcgc ccttttgaaa tgacatcaac 2526781 aaagccttca tacgaattat caaccatcga ttgcatgatg tttttttctt ctttcgtcat 2526841 ctcacgggaa ggagacataa tgtccttatg ggccccgctc ttaatcgttt caaaagaaat 2526901 gccaagcttg tcggcaagct ttgaataatt gacgctttcc ataatgacgc cgagtgaccc 2526961 ggtcagggtt tccggtgtcg caaaaatctt atcagccgct gttgagatgt aatagcctcc 2527021 tgatgctgcc atcgaaccca ttgacacgta aatcggtttt ttcgtttctt tcttgatttc 2527081 ttccagtttc ttatgtattt cagcactttc atacactccg ccacccggag aattcacctt 2527141 cagaacgata cctttgaccg tcttgtcatc ttttgcgcgc tcaaggtttt ttaagaacgt 2527201 tctgtggtta tatccgtctg caccaagcag actgcttgag tccccattat cctgaatggt 2527261 gccgctgacc tctaatacgg caattttact tgagggactg ccgttttcca gcgtcttctc 2527321 ctgcgattca tccgtcagtg atgtgagatc cgtttgagcg cctttgacgc tttcaaagaa 2527381 actcatagag atgctgacga taatagacac gccgaaaatc cccagagcaa tcactaatgc 2527441 aatccatctt tttgcattca ttttttctcc tcctttttcc taaactctct cattatacga 2527501 ttcaatatga aaaatgtttc acttcatgag aaagctccgg cttaacgggc tgccggcaaa 2527561 cgtggtacac ttatggccaa aggtatttta tcacaaatac tggatggcag aaaaacttaa 2527621 atatgacagc aaaggggaaa tgggatatga ccgatcaacg ccgtaatgtt tatttttttc 2527681 acaaacagga tcaggaaacg aacgaacaag cccgctcgtt aacacaatta gcggaagagc 2527741 atggatttac cgttgtgaac cagcactcag acgccaatat tatcgctagc attggcgggg 2527801 acggcacatt tttgcaggca gtcagaaaga cgaattttcg tgacgactgc ttgtacgtcg 2527861 gcattaccaa aaaggggaaa gctcatttat attgcgactt tcatagtgat gagcgagaaa 2527921 aaatggtcga tgcaatgacg tttgaacaaa ttgaagtgag aaaatacccg ctgattgaag 2527981 tgacagtgga tcaagccagt ccttttcact gcttaaacga ggtatccatc cgctcaagca 2528041 tcatcaaaac ctttgtgatg gacgtgctga ttgacgatct gcactttgaa acgtttagag 2528101 gtgacggaat gattatctca acgcctacag ggagcaccgc ctataacaag tctgttgcag 2528161 gagctgttgt tgatccattg cttccatgca tgcaggtatc agagcttgca tcccttaaca 2528221 ataataccta ccggacactc ggctcgccat ttgtcctcag ctctgaccga aagctgaccc 2528281 ttcgtgtggt gcaggacggc aacgaacacc caatcatcgg cttggacaat gaagcactca 2528341 gcacgagaaa tgtgaaaacg atcgaaatca aactgtctaa taagaaaatc aaaacagtca 2528401 aactaaagga caattcattt tgggaaaaag tgaagcgtac ttttttatag aaaataaaag 2528461 gacaggctgc tgcctgtcct tttatgattt ctcatataca atctggccgt taatcacggt 2528521 ttttttaatc tctaaaagat gaagctgtgc ggggtcaatg gcaaacggat caccactgag 2528581 aactgtaaaa tccgcgtcat agccttccgc aatttttccg cgtgacttct ctttataaat 2528641 gataccggcg ctaccttctg tataaagctt tatcgcttca tatacaggta aacattcact 2528701 ttcattatag cttggcccgt tttgctcatg actgcttttc cggaggaccg cggactggat 2528761 ccctagaagc gggtcaacag gctcaatcgg ggcgtctgaa ccgcccgcgc ataaaatgcc 2528821 tttagatatg agggttttcc aggcaaatgc agtcttcatc cggtcttttc cgagacggtc 2528881 aatgacccac ggaaagtcgc ttgcaacgaa gtgcggctga aggtcaagtg cgatcggcat 2528941 gcgtgctgct ctctcgatta attcgttatc aagcacttga gcatgaataa gccgatcatg 2529001 ccggccgttt ttgggcggat gcttttctat tgcgttcagc actttttcaa aagcaagatc 2529061 gccgattgca tgaacagcaa cctccatccc tttttctctc gctttgcgaa tgagccggcc 2529121 aagggtttcg tcatcgtgaa cctgaacacc atttgttgat ggatcatcct gatatggttc 2529181 tttcaataaa gccgttctcc cgccaagcgc cccgtccgca aagattttca tagcaccgaa 2529241 ctccacatac gggccggaca gcttctccag ctgctcccat cgatcgacag cttcatgatg 2529301 aacgagcaaa tggcagcgaa acggatactt tccgccagcg gcagctttct cataagcttt 2529361 catcggcacc gaaacatcac cataatagga caagtcttcc gaatgaccgc ccgtcaggcc 2529421 ttttgtccag caatccttta ttgcagccgt taatgcctca tcaacatagt gctgggagac 2529481 tggcgggaca gccttcagaa tcaaatcctg cgccttatca aacaggagtc cggtcggctc 2529541 gccatttgca tcttttacga tgactccgcc gtcaggatca ggagtatttc ttgaaattcc 2529601 cgctgcttga agagccgcag aattgacagc tattgcatgc cggcatatac gcttgagcaa 2529661 gacgggcctg tcaggaaaca ggcgatcaag atcatgctta gtcaagtagt caggtgtctc 2529721 aaactgattt tcattccagc cttctccaat gagccaatcg tttttaggaa gctgccgctc 2529781 tctttccttc gcagcctgta aaattgaatc tttcgacgtc agtgcggaca gatcgagctg 2529841 aagctgtttc tcaccgtggc cgatcaaatg tagatggctg tcaacaaaac cggggaacat 2529901 cactgctccg ttcaggctga tttcttctgt ttccggcgac ccgtactttt ccttcaaacg 2529961 ttcatagctg ccggtgcctt ttataacacc atcctcaaca taaactgcct cagtccgatc 2530021 gccttcttcg agcatcgtat aaatgaaacc gccgtgccat atcgccttca ttcacgttca 2530081 ctctctttct ttacgccttt ttattggctt tgagctgttc ttcacgtttt cttaattcca 2530141 ctcgtctgat ttttgcagaa gccgttttcg gcaggctttc cacaaattca atttctctag 2530201 gatatttgta tggagcggta atcgtcttca catggttttg cagcattttg acaagctcat 2530261 cactgcgttt ttcatgattt tgcaggacaa catatgcctt tacgatggag cctctgattt 2530321 catcagggct tgcgacaaca gcacattctt ttacttctgg gtgcttaaca agcgcgtctt 2530381 ccacctcgaa aggcccgatc gtatagccgg agctgataat aatatcgtca tttcggcttt 2530441 caaaccagaa gtaaccttcc tcatcttttc ttgctctgtc tcccgttagg aaataatcgc 2530501 cgcgaatttg tgttttcatt ctttccggat ctttaaaata ctctttaaag agcgcaggcg 2530561 tactgaggtg aacagcgata tcgccaacct caccaggttt gcagatttca ccgtcttcat 2530621 ttatgatctc cacctgattt cccggtgtcg gttttcccat gcttcccggt ttaataggcg 2530681 tatctttcaa aacaccaacc aaaagcgtgc tttctgtttg gccatatccg tcccgtacct 2530741 taatgccaaa gtgcttttgg aaaacatcaa tgacttcacg gttgagcggc tcacctgcgg 2530801 aaacagcgct gtgcagggca gaaagatcaa agcgtttcaa gccttcaacc ttcgccatta 2530861 agcggtattc tgtcggagtg cagcagaaaa cattgatttt gtagcgattt aaaagctcta 2530921 gatatttttc tgctttgaat ctgccgtggt acacaaaacc ggttgctccg ctgccaagca 2530981 ccgctaaaaa cggactccat acccactttt gccagccagg ggcagcagtt gcccagacga 2531041 tatccttttc agaaatgtca agccaagcgc cggcagaagt ttttaaatga gcaaatgccc 2531101 atccatgtgt atgtacaaca cctttcggct gacctgttgt cccggatgta taagataaga 2531161 aagccatatc atctcttgtt gtgtcagctg ttttaaattg gcttccgtcc gcttcaattg 2531221 ataagaggtt tttccagccg gcatcatttt caccaataga cagtgtaatc agtttgtcag 2531281 ccgtactgac atcccggaaa gcgccaataa attcggagta gacgatagcg ccttttacct 2531341 ctgcatgttc aatccggtat tcaagatctt tcgcgcgaag catttcggag cacggaatga 2531401 caaccattcc tgatttcagg atagccaaat aaacagcata ggcttcaagc acccgcggaa 2531461 ccattacaat cagcttgtct ccctttttaa atccaagatc agctaaggcc gctccgattt 2531521 tatttgtttc ttccatcagc ttttcatacg accaagattc ttgcttgccc gactcgtcct 2531581 cccaaagaag agcggttttt tgtccagcag cactgaactt ttccatttca ttcactaaat 2531641 tatattgcac aggggcaatt aaatcttcac gttttaacac gaacaactcc tcactttctc 2531701 cacccattat acataaatac aggctctttc cgtaaggata tgcctaaaag caacctctgt 2531761 aaacatagat tttataggcc gctggtcctt ttttatatgt aaaaaatgaa aaagagtggg 2531821 gataccccca ctcctaagcc attatgtgaa attgtaaatt agaattgtcc tccgcccatg 2531881 ttttgttgag caaaagatac aagacgtttt gtgatctctc ctccaacaga accgttagcg 2531941 cgagaagttg tgtctgctcc aaggtttaca ccgaattcag aagcgatttc taatttcatt 2532001 tggtcgatcg cttgagcagc tcctggtact aaaaggttgt tgctgttacc tgagttattg 2532061 ttagccatgt gtctcacctc cttgtgagta tagaatgtgt caaaacacat ggcttcattc 2532121 agaaaaactt tggtaattgt atacaggagc tgaaaattga tttaaaagag ttcagcgaat 2532181 ttatcgttag cttcttgttc gctataaagg gtcattgtct caatgttatc taccgcttct 2532241 tgaatatacg gctcgaaatc aacaaagctt tcaaagtgtt caattttctc ttttttaggg 2532301 cgtgttttcg ggcttggcgg tgtaaagatc gtgcagcagt cttcaaacgg ctgaatactt 2532361 gtctcatatg tgccaatttc ccgtgatttt tcgatgattt ctgttttgtc catggcgatt 2532421 agcggacgca aaatcggtgt tgacgtcacc gcattaattg catacatgct ttcaagcgtt 2532481 tggctcgcta cctgaccgag gctttctccc gtaataatgg caagcccgtt tctcttttct 2532541 ctgattctgt cggctatctg aagcatgagg cggcgggttg ccgtcattgt gtaattttca 2532601 ggaatttgtt tttggatgag ctcttgcgtt tttgtaaatg gaacaatatg aagtgtcatg 2532661 cttcccccaa aacgggacag acatttcgcc agatccatta ccttttgctt tgcgcgctcg 2532721 cttgtgtatg gcgggctgaa gaaatgaaca gcttctaccg acaatccccg tttcatcgca 2532781 taaaaaccgg ccacagggct gtcaaaaccg ccagaaagca tcagcatcgc ttttcctgct 2532841 gaaccaactg gcagcccgcc tgcacctttt tcatcacgaa ttgtcaaaaa tgttgcttct 2532901 tccctgattt cgattctgag cgggatgtct gggttgcgaa catcgaccgt caatccttct 2532961 gtatttcgca aaatatggcc gccgatttca gcgttcatct ggtttgtatc taattcaaat 2533021 tgcttatacg ctctctttgt cgcgacttta aacgtatcac ctggtttata ctgatctttg 2533081 atagccttta gtgcggttgc cttaatatca tcaaggcggc tgtcacactt aattgccagg 2533141 ctgaagcttt gaatcccaaa cacttgcttt aaatgaggaa aaagagcctc aggatcctct 2533201 ccatttaatg taatcgtcat acgatccctg ttggaaaagt attttaaatt cggatagtct 2533261 ttcaaaacga gtctgatgtt ttgttttaag cgctcaataa agctttttct gtttttgcct 2533321 ttggtcgaaa tttccccaaa acgaattaat atatgatcgt aattcatgtt ctacctcatc 2533381 atttccctta attttttgat gccaggacga agcgcgttca taaacggttc tgccacatcg 2533441 cttgtctggc tgtaatttaa actgattctg atgctgcttc cggcaatctg ctctcctttg 2533501 cccatctcta agagaacctt gctgggctta tgttcttttg ccgagcaagc cgatgttgtg 2533561 gagacgaata tatcctgttc ctcaagcatg tgtaaaagca cttccgcttt aatccccggt 2533621 acagagaaat taataatgtg cggcgcgcta ttcatttgag gcgtgttgat aacgacgccc 2533681 tcaatttcac tcagcctatt cataaacaat tcctttacgg cagtcatcgt gtcaagccgt 2533741 gtgtcaaaat cagcagaggc cagattaatg gccttggcaa gcgaaaccgc accagcagta 2533801 tgttctgttc cggcccgtat gcctttttgc tgagagcctc ccgttatgag cggaataagg 2533861 cgtgttcctt cttttacaat aagtgcgcct gtccccttta ggccgtgaaa tttatgcccc 2533921 gaaattgaac atagatcaat gccggccttt tcaattgcca agggcacttt atagatgccc 2533981 tgcacataat cgacgtgaaa caaaatgttc gaatgctctt tcagcacttc tcctgccgct 2534041 tcaatcggct gcacggaacc gacttcattg ttcacatgca tcatgctgac aagcacggta 2534101 tcgggacgga tggctgcttt tagatcttca atagaaacaa atccgtcttc attcacagaa 2534161 agataagtga tatcaaaccc gaacaactct ttcagctgtt ctaacgattc cgtaacggat 2534221 ggatgttcaa tagaagtggc aatgatatgt ttgcctgttt ttatctttga caaagccgct 2534281 ccttttaaag ccgcattatt ggcttctgtg gcgcctgacg taaatacaat atcatatttt 2534341 tttaggccta aggacctttt gatttgattt ttggctgctt gaagcagctg ttccgtttcg 2534401 gctccatatc ggtgcaaaga tgaaggattg ccaaagtatc ggctgctcgt ctgttcatat 2534461 acgttcaaga cttcatcgta aggcttcgtc gttgaactat tatctaaata tatcatcttt 2534521 tttactcctt tatgaaagcg gtacaaggta tgatatttat gttaccataa caaaatttaa 2534581 tagaaaatta cgaaaaacta gtattgactt ctaatttttt taccatataa taagatttgt 2534641 tcgtttcgtc atattatctg acaattaatt gacagaatat tttaacataa ttattaggag 2534701 gatttttttc atgaaacact cactgcctgt caaagatacc attattattg gtttcatgct 2534761 atttgcgtta ttctttggag caggaaatat gatttatccg ccggaacttg gacaagcagc 2534821 cggacacaac gtctggaagg ccatcggcgg atttttactg acaggggtag gcctgccgct 2534881 tctcggcatt atcgccatcg cattaaccgg taaggacgct aaaggccttg ctgacaaagc 2534941 gcaccctgtt ttcggcacaa tctttactgt cgtgctttat ttatcaatcg gaccattatt 2535001 cgccatcccg agaacaggaa ctgtttcata tgaaattggc gctgttccgt ttttgactgg 2535061 tgtaccagaa agactttctt tattaatatt tacacttatc tttttcggcg ttacgtacta 2535121 tttagcgtta aacccatcta aggttgtgga tcgagtcgga aaaattctga ctcccatcaa 2535181 attcacaatt attttaatca ttgttctcaa agccatcttc acgccgatgg gcggattggg 2535241 cgccgtgaca gaagcatata aaggaacacc ggtttttaaa ggatttttag aaggctataa 2535301 aacaatggac gcacttgctt caattgtatt tggcgttgtc gttgtaaatg ctgtaaaaag 2535361 caaaggcgtt acacagtcta aagctcttgc tgcagcctgc attaaagcag gtgtgattgc 2535421 cgctttaggc ctgactttca tttatgtatc ccttgcttat ttaggtgcaa caagcacaaa 2535481 tgccattggt cctgttggtg aaggagctaa aattttatct gcgtcttccc attatttatt 2535541 cggttcattg ggcaacatcg tactcggagc agcgattaca gtcgcatgtt taacaacaag 2535601 catcggcctt gtcacatctt gcggccaata tttttcaaaa cttattccgg cattatcata 2535661 taaaattgtc gttacgattg tcacgttatt cagcttgatc attgcgaatt tcggactcgc 2535721 gcaaattatc gcgttttctg ttcctatttt atcagctatc tatccgcttg ccattgtcat 2535781 tatcgttctt tccttcatcg ataagatctt taaagaaaga cgcgaagtgt acatcgcatg 2535841 cttgatcggt acaggacttt tcagtatttt agacggtatc aaagcagccg gtttttcact 2535901 tggatcttta gatgtgtttc taaatgcgaa tcttcctctt tacagcctcg gcatcggctg 2535961 ggtgcttcca ggaatcgtcg gagcggttat cggctatgtg ctgaccttat tcatcggacc 2536021 atccaaacag cttaatgaaa taagttaatg tcacagaacg cctgcgttat tgcgcaggcg 2536081 ttttgtaata aaaaaagagc ctgctcatta cactgcgggc tctttttcat ggtcgtgatt 2536141 atctaagcgg atatgtcagc tttgattttt tcaactgcac ctggcgcagc cttttctaca 2536201 gcggcagcgg caatttcata agagtcgtca taatcaaaag cataaaaacg tctttccgct 2536261 tctttcagct gttcagataa aatatgattc tggcttctga accggtttcc gaactgaatg 2536321 attttttcaa tgaggatgac ctgctcgaca agttcctctg attcccggct tgccctgttg 2536381 acgatatctt ctgcttgttt caaatgggct ccggcttctt ccatatttaa tggaagttcg 2536441 tttagttgat tgaccgtttc ttgaatatga tgatgcgcgt tctccagcat ctcttgaata 2536501 tggctcggaa tgcctggaat gttgctagtc ttcagcagtc ttgctgtctc agaaattgtt 2536561 tttttcaaat tgctgagcgt ctccctcgcc tgaagctctt cttttctcag cgcttgcaga 2536621 ttttcacgat actcggcatg ctcttttttc acttcttcaa tttgcttctc tattgaagca 2536681 acttcttcta ctaaaagtga gtaggcgaca tgctctgcat caagcttatc tttaacggat 2536741 gatagcagct ttccaatttc atcaaggcgc ttttcaaaag cctgctgttt gccgagctca 2536801 ccggctgtca gcctgtagct ttccttcacc agctcagttt ccgctttcgt atgctctttc 2536861 tcttctttaa gcttgtcgta agcaataatc aattcaggca ttttgcttag tacggattga 2536921 ccggcttcaa cttcgccctc cagctgctga taaacagatt gaatattttc gtcaatgagc 2536981 tgcaggattg cggacgcttc atcaatatcc agttcagtca tcaggacatg ttccgctcgt 2537041 ttcagctggt ttgacagatt ttctaattcc ttatcaagct ggatatgctc aagcttgtac 2537101 cctttttctt tcatttcgcc atagccatcc ttgagctttg caatctgtcc gggcaccgtc 2537161 tgtttacagt cagctaacag cttcggcaca tcatctatgt atgactgaag ccgttcaaga 2537221 ttgcggtcct gctcaagcag tacttttcgt gcagtaatat agtttccgcc ttctgtttct 2537281 tcttcaaatt gtttgatgcc gctccaaatt tcgtccagat ccttttcaag gctgtcataa 2537341 agctccccgt aaaggtggct gtaagccagc aggttttttc gagatttcga atagcgctcc 2537401 ctcacctgtt caatctcttc acggctcttt tcctcacttg tgacaagatc gctgatttcc 2537461 cgaagaatct tttcaatgct tgattcagcc gctgtcagca ggtcgtcgat atgaacgagc 2537521 acttgattgg cctttttaaa ccggtatttg tctgcatttt cctcggcatc ataaaggagc 2537581 tcttcaactt tcggcatgtg ggctgtgaca atctcatccc attcttcacg ccacttctca 2537641 aagaactctt ctgtctgacc cgtcattttt aaatgtttta ttttagacat ttcttccacg 2537701 atcgaccgat tcagaatttc aatcttccac gattccagcc ggtcgatttc ggcgtagatt 2537761 tttttcctga aaaagtagcc tgccgcaaac agcgcaagca gtacaattaa taatccaatg 2537821 acaaactcca taatgagccc ccttgctgtt taccttaatc tgtcagggtg ttttatttat 2537881 tcagaaagat ttcaggatat gtattgagaa aaactgtcgt tttcattgtt attatgatac 2537941 catgtaacaa acattttttg accagaaatc aaaaactttt tgtgcaaaat cggcaggatt 2538001 tgactatttt ttcatggggt gacatcaatg caaaagcgag acggacatat tcacacacca 2538061 ttttgccctc acggctccaa tgacacactc agacaatatg cagaagaagc cttaaaaaaa 2538121 gggttcgaat cgattacttt taccgaacac gccccattgc cgccatcttt taccgatccc 2538181 acgccgctga aagacagcgc gatggcgcaa gcttctttgg aacgctatat tcatgaaatt 2538241 tccggattaa aaaaagaata tcgcggacag cttagcatac ggacagggct tgaagtcgat 2538301 tatatcgctg aatttgaaga cgaaattaca ttattcctag acacatacgg gccatattta 2538361 gatgacagca tcttatccgt tcattttttg cgcacagact cttcctatct atgccttgat 2538421 tatgacgagc ataccttcaa agagctgatt tcagcctgcg gaagcattga agcggtatat 2538481 gaacaatatt accggagtat ctattcttcc attgtagcat ctctcggcgt ttataagcca 2538541 aaaagagtcg gtcacatcac actcgtccaa aaattcatca agctgtttcc atacagcatg 2538601 tcagagcata ttcgcggcct cgtttctctg tgcctgaatg ccattgaaga aaacggaatg 2538661 gagctcgact tcaatacttc cggcttaaga aaaacttacg ctggcggtat ttatatcgag 2538721 gattggatgc tgaatgaagc gaagcaaaag aagatcccgc ttgtgtttgg gtctgatgcc 2538781 catcaagcgg gagatgtcgg atatgcgtat gaggcgtttt tggaacggtg ctagttggtg 2538841 agcgccacgt ctcctgtccg gaagacgctt ctgatccaaa tcttgatttc ttcaaaatac 2538901 attttataaa aatacggctc gtgcggctgc atgtagagta cttctgaaat atattgaggc 2538961 tggagatagg gcatcatcaa gagagatttt aattggagaa taaaatgagg cagcggcagc 2539021 gttaaatatt cacgctgttt ttctccttcc tcaatgatca gctggaagat atacttttcc 2539081 ttcattagat atgtcgacat aatttccctg attaatgtgg agtcaattgt gacttcccgg 2539141 tagacaaaac gagttaattg acgatgatta tgctgatagg ataaaatatc gaaaaccaat 2539201 tgaagaagct gttcctgcgt gctttgagta gagatattgc ttgccgctgt ttcaagcgtt 2539261 ttgctgtagc cttcgtaaaa ctctgaaact aagtgttcca tcaagcctcc tttgccttta 2539321 aaatagtagg agatgtgcgc aacatttaca tcagctgact ttgcgatttc acggacagac 2539381 gtgccagaaa atcctttttg gttaaaaagc atgacagcag attcaataat tttgtctttg 2539441 gtgcttactt tcatacggct cactccttcc tcttgatact attcaagcag aaagccgctg 2539501 ttcctgtaag aacttatcga caaatgccgg cagaaaagcc ggaactttgt tttatattat 2539561 agaaaaagtg agggttttcc atgttccatg tcgaaaaaca atctggagat aaagaaaaag 2539621 actatcagct tctgctaaaa cagctcgaag ccatgaccga agacgaaaca gaccaaatag 2539681 ctaactatgc aaatgcctca gcactgctgt atcattcgct gcctgaagtc aactgggcgg 2539741 gtttctattt tgccaaagaa gaggatggac agcttgtgtt aggtccgttc caaggcctgc 2539801 cggcatgtgt tcggattcct ttcggcagag gggtttgcgg cacagcgtac gcaaacggaa 2539861 aagtggaacg tattgaggat gtaaacgcgt ttccgggaca tatcgcctgc gatgcagcgt 2539921 ctcaatcaga aattgtgctt ccgattcgtg tagacggaaa aattgtcggc gtcttggaca 2539981 tcgacagccc agtgaaaaac cgtttcgacg aaattgatga aaaatactta actcaatttg 2540041 ccgaaacgct agaaaaagcg ttagcgcagt aatataaaag cccaaaactg atatcgtttt 2540101 gggctttttt tattttattg agtcatgaat catcaagcgg tttttcccgc tccgtttcgc 2540161 gctgtagagc gcttcatctg cctcatgcac aagctctttc agcgactttt ttgtttctgt 2540221 cgtccagcag gagataccgc aggaaatggt tacctcgggt ttcgtatttt ttctgaccgc 2540281 gtaaaccagt cgctcggtaa tccgtttccc cactgcaacc ggcacatttg gcaaataaat 2540341 cgccagctcc tctcctcccc agcgggcacc gacatcatgc tttcggatgt tgcttttaat 2540401 cactgaagcg acttgaatta aaatctcgtc cccagtctga tggccgtacg tatcatttac 2540461 atttttaaaa ttatcaatat caacaagaat aaaaacaccc ttttgatgga ttttcatgct 2540521 gtattgaatt ttttcatcta aatacgctcg tgaatacagt tcagtcagct gatctgtttt 2540581 cacgagatgc tcaaggcggt cgcgaagcat tgaattggtt acagccagtg tcgcgtgatg 2540641 aatcagcgcc tgaaacagct tgtacatttc aaatgtaaaa gcgtacagct cctgtttcaa 2540701 taaaaccgca aagcctaaaa gccggtcgtt ttgaatcatc ggagcagcca tcagcgagcc 2540761 gtaccccgcc ttcccaaaaa cagactggcc attcccgatg aaaacccctt tttcaccttc 2540821 atacagcttt tctttcagct cattataaaa atctgacggc ttcgcttctt taaaaaatgc 2540881 tgtgctgcct gggagcaatg ttaggttttc aaaatggtct atatgaaaaa atcccacttc 2540941 ttctgcctga aacgattctg ccattctcac agccagatca ttcattgtat cagtcaatgt 2541001 cagccgctga ttcaggcgtc gtgatgtttc attaatcaat tccaaatttg cgatgcttgc 2541061 tttggattgt tcgtagagct gggcattttc aaacgctttt cccgcggcgt ttgctaacag 2541121 cgacatttca tcaaggcagg catcagtaag aaagctgtca cccgttcctt cagccttcaa 2541181 caccccgtat gtgccctgct gtcctttgat cggaatatag gcgacagatt catttttccg 2541241 caaaatgtct ccggacaaat acactttgag cgcaaaggaa tcggattttt ccccttccat 2541301 atacagctct tttgcaggaa tccctaaaca ttggtcttga tcgtgcgata taaataaaga 2541361 aaactcaaaa agagaaaatg tgcttgtcaa gctttctaaa agctgcttca gcacatctgt 2541421 ctgatcaagc agtgaatgga acagctctgt cattttgtat atcttttttt ggtagatcgt 2541481 tttgttatag agtctttcct gtttcatcga ctggtttaaa aatgaagcaa ccacgtccgg 2541541 aagcccttca ggaatctctt catcctgcct gcacgcaaga tggaaacgcc tgccggagcc 2541601 gtcctcaatc agataacatg aagcgtttat ttttgaagcg gaaaaacgcg cttcaccatc 2541661 tgccagtttt gtcacaaagt ctgatggtga cggtgtaagc gaaacacaaa gggttgaaaa 2541721 ataggtttga atagccgaag tcagccatat gaaagagtcg gtgaatgtga ctttttcaga 2541781 tttggttaat aaaaaatcga gcatatgata atgaaaggcg gataattgat ctttagtttg 2541841 ttctaccatg tttttatcac ctaaaagttt accactaatt tttgtttatt atatcataaa 2541901 cggtgaagca ataatggagg aatggttgac ttcaaaacaa ataaattata taatgacctt 2541961 tgtgtgaaat attgcagcct ttttgttcag cttctatgtt ttcattttgt tccttatcaa 2542021 taaggtgtat cgtgtaactc tctgctgctg gagcgaggat acatgaaaac aaaatgtgca 2542081 tggtcgaata gagcagacgg tttttatttt ccacaaaaat aaaaccaaag gaggagtcac 2542141 attatggctc gctatacagg tccatcttgg aaactgtccc gccgtctagg aatctctctt 2542201 agcggtacag gaaaagaatt agaaaaacgc ccttacgctc caggtccaca cggcccagga 2542261 caacgtaaaa aattatcaga atacggtttg caattgcaag aaaagcaaaa gcttcgtcac 2542321 atgtacggtg taaacgaacg tcaattccgc actttgtttg acaaagctgg caaactagct 2542381 ggtaaacacg gtgaaaactt catgattctt ttagattctc gtcttgataa cgttgtgtac 2542441 aagctaggtt tagcacgtac tcgccgtcaa gctcgccaat tggttaacca cggtcacatt 2542501 cttgtagacg gaagccgcgt tgacatcccg tcttacctag tgaaacctgg tcaaacaatc 2542561 ggtgttcgcg aaaaatcaag aaacctttct atcatcaaag aatctgttga agtgaacaac 2542621 ttcgttcctg aataccttac tttcgacgct gaaaagcttg aaggtacttt cactcgtctt 2542681 cctgagcgtt ctgaacttgc tccggaaatt aacgaagcgc ttatcgttga gttctactct 2542741 cgttaatcgt tttaaaaacc cctgccgcta tgcggtcggg gtttttttat cggctttcgc 2542801 ctcttgctgg ccaacactat cttgcgcctg ctgctcccaa tgatcccgct gcagccgttc 2542861 ttttgcaatc gtacacatga gattcacgct ttagcgctcc tttcatttaa aaggtggtga 2542921 ttggtcgtgt ttgccctatc taatatactc ttttcctttc attcctatgc ggtaaacaaa 2542981 aagatccttt gccttcagtg gcaaaggatc tttttcttat ttatacgtca caaggaagta 2543041 ttttttcttc ccgcggcgca gaacagtaaa ttggttttcg atgcggtctt cacctgatag 2543101 ggtataattt atttccgtct ggcgttcacc gttaatgtaa acagctccgt tttggatgtc 2543161 ttcacgcgct tggcgtttag aaggagataa tttagattgc accaacacat ctacaagtga 2543221 aagctcttgg gtgctgtcaa cttccataga aggaacatct ttaaagccta cttttacgtc 2543281 ttgagcagaa agctctttaa tattgccgct gaacagcgct tgggagatgt tgatggcttg 2543341 ctccagcgcc tcgcgtccgt gaacaagtga tgtcacttct tctgccaggc gtttttgcgc 2543401 ttcacgtttt tctggcgccg tttctgtttt ttcagcgtat gcttcaattt cctcttttga 2543461 aaggaacgtg aagtatttca agtatttgac aacgtcacgg tcgtctgtgt tgatccagaa 2543521 ttgatagaat tcatatggcg atgttttttc tttatcaagc cagatcgcgc cgccttccgt 2543581 ttttccgaac ttcgtgccgt ctgcttttgt gacaagcgga atcgttaggc caaacgcttt 2543641 tgctccttct tcttctgatt ttctgatcag ttcaagaccc gctgtgatgt tgccccactg 2543701 atcgcttccg ccgatttgca gtttacagtt tttgtctctg taaagattta agaaatcata 2543761 agattgaaga atcatgtagc tgaattccgt gtacgagatg ccggattcaa ttcttgagct 2543821 gaccgtatct tttgccagca tgtaattgat gccgaaattt ttaccaacgt cacgaaggaa 2543881 atcgatcaca ttcattttgc cgatccagtc aaagttgttc gcgatgacag ctgggttttc 2543941 tgctgcttca aaatctagaa atctggacag ctggtttttg attttttggg accattcgga 2544001 tacgatgtca gcagtgttta atgtacgctc tgcttttttt ccgcttggat caccgatgag 2544061 gcccgtcgcg ccgcccacaa gcgcaatcgg atgatgccct gcaagctgaa aacggcgaag 2544121 tgttaaaata ggcagcaggt gtccgatatg caagctgtct gctgtagggt caaagcctga 2544181 gtacaagcgg attttttctt cattcagctg tttatttaac ccttcttcat ctgtcatttg 2544241 ctgaatcaat ccgcggaagg ataagtcttc aagtaagtta gtcataagat aaagctcctt 2544301 ttttaattaa aataaaaaac gccccttcgt ttacacgaag ggacgattga ttatcgcggt 2544361 accaccctac taataagaga atgcaaacat tcgtcttatc actttgcctg ataacggatc 2544421 aggtccgttc tttcactact gaaagcctgg ccggctttgt ttgcaaaagc ggttcatgag 2544481 tgtattcgat atatccgtct gtgctgattt tcaccggcca tcagctctct ggaacgtaag 2544541 gatattctac ttgtctcaat ctttaccttt tcatatgaag ctatatcatt tttaacataa 2544601 ataaaatcct gtgtcaacgc cgccttttaa tcctccattg ttgacagatc tccagccggc 2544661 agattaagct cccatgcctt cagcacgcgc ctcatgatct ttccgcttct ggttttcgga 2544721 agcttatctt taaattcgat ctcacgcgga gccgcatggg ctgcaagacc ctgctttaca 2544781 aataggcgga tctcttcttt cagtttatca gacggctcaa atccttccct gagtgcaata 2544841 aaggctttaa tgatttctcc acgcaccggg tcaggctttc cgataacgcc tgcttctgca 2544901 atagccggat gttcgacaag cttgctttcc acttcaaatg ggccgacgcg ctcaccggag 2544961 gtcatgatga cgtcatcaac tctgccttgg aaccaaaagt atccctcttc atccatgtaa 2545021 gcagaatccc cagacacata ccagccgccc ggcatgaaat acgattcata cttttcaggg 2545081 ttattccaaa tggtatgcat catggaaggc cagccctttt tgatggcgag attgcccatt 2545141 cggtacggcg gtagctcgtt gccttgattg tcaacgatcg ctgcctccac tcctggaatc 2545201 ggcttaccca ttgaacccgg tttaatatcc atgcaaggat agttgcagat gagctgactg 2545261 cccgtttcgg tcatccacca ggtatcatgg attcgtttgt taaaaacttt atgtccccat 2545321 ctgatgactt ccggatttag cggctcaccg acactgagca catgccggag tgaagttaga 2545381 tcatatttcg cagccatttc atctcccgct cccatcagca tccgaaaagc tgtcggcgcg 2545441 ctgtaccaga cattgacgcc aagctgttca atcgttccat accagctttc cgggctgaaa 2545501 cgtccgccga cgatgacatt tgtcgctccg ttcagccacg gtgcaaaaat gccgtatacc 2545561 gtacctgtca cccagcctgg atcagccgtg caccaataaa tgtcttcttc ctttaaatca 2545621 aggacccact ttcctgtttg atattgctga atcatcgctt catggacatg caacacgccc 2545681 tttggcgtac cagtggaacc tgatgtatag tgaagcagaa agccgtcttt tttatccatc 2545741 cattcgatat ccaatcttgt gctttcctgt ttcgctgctt catcataatt gatgatattc 2545801 gtgccgctct cagcctctcc cccgactacg aagacatgct gcaagtgagg cagtttgtct 2545861 accggtattc tctccagcag ctcaggcgtt gtgacaacaa cctttgcctc actgttttca 2545921 agccggtctt tcaccgctcc ctccataaat gcttcgaaca gcggcccggc gatggcgcca 2545981 attttgattg cgccaagcat aataaaataa agctcgggtg atctcggcat aaaaataaaa 2546041 acgcggtccc ctttttccac atttccatac cgtctcagca cattcccggc tctgtttgat 2546101 tcttccttca tttctttaaa tgtgtatttt tcatcccttt ttgcgtcttt ataataaagc 2546161 gctactttgt tttttcgaaa cgattcggca tggcggtcaa tcgcttcata cgccgcattc 2546221 agtttccctg tctcatgcca agagaaatgt ttctctgcct cggcccaatc aaaatgccgg 2546281 tacgtttctt catagttttt taagttatga tccccctcta ttgctggtaa cgctttcaag 2546341 ttcatgccca aacatccccc tttgctgaag ttgtcacaat tattatagta tatattcata 2546401 ttcttctcaa tttttaaaat ataaaccatg ttgaaaacgc tttataattt ggtattctta 2546461 aagaaggcat gtatttttga taagaattga tgggacggtg aattagtgga acatcataaa 2546521 acataccatt cagcaaacat caaaacagca accggctctt tactgataga agggcctgtc 2546581 tctccagagg atttggcagg ttatgagttt cataaagatt taaccgcatt tcgcccgcct 2546641 cgcgagcagc atgaagcgct agtcgacatt gcaggccttc ccgaagggcg cattattatt 2546701 gccagagacg gccgaaccat tgtcggctat gtcacgtatt tatatcctga cccgctcgaa 2546761 agatggtctg aaggaaatat ggaggatttg attgagctcg gagccatcga agtagcgccg 2546821 gactatcggg gatgcgctgt cggaaagacg ctcctgaccg tcagcatgat ggatgaacaa 2546881 atggaaaact acattgtgat gacgacagaa tattactggc attgggattt aaaagggatg 2546941 aaaaaagatg tgtgggaata cagaaagatc atggaaaaga tgatgaatgc aggcggattg 2547001 gtctggtttg caacggatga gccggagatc agctcccacc ctgcaaactg tctgatggcc 2547061 cgcattggaa aaaacgtcag ccaagaatca attgagcaat ttgacaggct ccgtttttat 2547121 catcgttata tgtattaact gacactgaca aaggggaaaa aataatgatt gttgagcaaa 2547181 tcatgaaaag agatgtcatt acattaacga agacggatac gcttgaaaca gcaatatgca 2547241 aactgaagga attccatatc aggcatctgc ctgttgtaga tgaagaacga cacgtgatcg 2547301 gcatgattac agacagggac atgaaacagg ccagcccgag tatttttgaa gaaaacaaac 2547361 gaagcctatt tctcacacga agcgtagatt caattatgaa aaaggatgtt gtctgcgccc 2547421 acccgttaga ttttgtcgaa gaaatatcag ccgtgttcta cgagcatggc atcggctgcc 2547481 taccagtggt acaccatcaa aaattaatag gcattttaac aaaaaccgat ttgctgcgga 2547541 cgtttgtcaa attgacaggc gctgaccagc cgggctcgca aattgagata aaagtaaacg 2547601 acatcaccaa aagcctcgct gagatcagca gtctttgcca agaccttcaa gtgaaaatat 2547661 taagcgtgct tgtttatccg catgacgatc ccggtgtaaa agtgcttgtc ttccgtgtaa 2547721 aaacgatgaa tccgctgccg tttttgcagg cattacaaag aaatggacac cacgtcgtat 2547781 ggccgtcaga gcaaagggat ctgctatgag agacagtgta tttatctatt ctccatccta 2547841 ccaaacctat atgtttcatc aggagcatcc ctttaatcag cagcgggttc tgttaacata 2547901 tgatttgctt aagacgatca atgcctttga tgatggagac attgtcaccc ccagactcgc 2547961 ttcagaagag gagctttccc ttgtccacac ggacgattac attcaggccg taaagcttgc 2548021 gggcgccgga aagctccccg ctgaagaagg agaaagctac gggctcggca ctgaagacac 2548081 acccgtcttt gccggcatgc acgaagcggc atcactcttg gtcggcggca ctttaacggc 2548141 cgcagactgg gtcatgtcag gacaagccct gcatgcggca aaccttggcg gagggcttca 2548201 tcacggcttt cgcgggagag catcaggatt ctgcatatac aacgacagcg ctgtggctat 2548261 tcaatatatc cagaaaaaat atagcgccag agtgctttat attgatacgg acgcccacca 2548321 cggggacggt gtgcaattta cattttacga taatcctgac gtatgcacgc tgtccattca 2548381 tgaaacagga aggtatttat tccctggaac cggtcagatc caagaaaaag gaagcggaaa 2548441 aggatatggc tattccttta atattccgct tgacgctttt acagaggatg attcttttct 2548501 tgaggcttac cggacagcag cttcagaagt cgccgcgtat ttcgagcccg atgtcattat 2548561 cagccaaaac ggcgccgatg cccattacta cgacccgctg acgcatttat cagcaacaat 2548621 caatatatac gaagaaatcc cccgtcttgc acacactttg gctcatcaat attgcggagg 2548681 gaaatggatt gcagtcggag gcggcggata tgatatttgg cgtgtcgtgc cccgcgcctg 2548741 ggccagaata tggcttgaaa tgaagggaat tgacccgggt cacgagatcc cgccggaatg 2548801 gattgttaaa tggcaaaaac aatgccccgt ggcccttccg tcgagctgga gcgatccggc 2548861 tgatttatat cctccgattc cccgcaagcc tgaaattaca gaaaaaaatg cccaaactgt 2548921 cagcaaagca ttatatgcga tacgttctga acagcaaaga acaaagtaaa aaacgacctt 2548981 tacgaagagg tcgtttttga ttttttaatc actatttcca cacgccgatt ttccttcatg 2549041 tgttcatttg tcttgttatc ctttactggc tttgtatccg cataaccgac agcaataaag 2549101 cgcttggagg gaagcttctc tttagacgtg aagtattgaa tcactccact tgcccgtgct 2549161 gctgatagct cccagttcga cgggtatcgg tatgtcgaaa tgtttcggct gtctgtatgt 2549221 ccctcaacct gaatgtcatt tggaattgtt tgaagaagaa cggcaatttg gtgaagaagt 2549281 gtttcggcat ttttcagcac ctttgcctca cctgtatcaa acagcacagc ctcctgaaga 2549341 acgagcacga caccgcgttc atcccgtttg gctgtcattt gggccttcaa atgattgtct 2549401 tttatatatg tatttacttt cttgagaagc tgatcctgct gatcctcttg cttcttcgta 2549461 tcagatgggg atgtattctt tttttctatg gatgtttggt ccggctgaag cccgttgcct 2549521 tccttctgga tcgagtccac tgccgctttg aatttttgca gatcgatttg ggacatcgaa 2549581 aagagtaaaa taaagaacac aaggatcaag gtgatcagat ctgtaaaggt taccatccag 2549641 ctggatgaag attgactgtt ttttccgctt ccattccttc tttcaaaacg ttctcttcta 2549701 agcttcatgt acagatccct tttttgtttt tacttgtttt ggctgcttct gccattcttc 2549761 ccgtgagctg aaaacgacca gctggctttc aaggttgcgc gggttttttc cggattgaac 2549821 accgataatc ccttccacca ttacctgctt gatgaaaatt tcactttctg ttttctcttc 2549881 aagcttagcc gcgatcgggt tgaagaccat atttgccagt aatgaaccat ataaagtcgt 2549941 cagaagcgca atggccatgt ttggtccgag catatgcggg tcgtttaagt ttttgagcat 2550001 cagcacaagc ccgacgagtg ttccgatcat tccccatgcc ggagcgaatt ctcccgcttt 2550061 ttcaaaaact cgccgccctt ttcggtgccg ttcctccatt gctgcgattt ctgaatccat 2550121 gacgagccga atcgtttctt catcccagcc gtcaatcgct aaaagcagcc cttttttcaa 2550181 gaatggatct ttgatttccc gagcctgatc atccaatgat aaaagcccgt gttttcgcgc 2550241 gtgatcggaa agggaaacaa aggttttcac aagatctttc acattgtctt cctggcggat 2550301 gaatgcctgc tttaacacag agggcgcttt tttcagctca cttggcggaa aactgataaa 2550361 aacagcggcg caaagtcccc ctgttacgat gaagaaagag gtcagatcaa gaaaagagcg 2550421 gaaaccgctt actcccgatc ctgaaataat cccgataaca ataataatcg ttcctaacac 2550481 aaatccaaca ggtgtaagat aatcaaaacg tttcatcatt tctccccatg aaaaaagcaa 2550541 gaattcacca taaaggtgaa gcttgctctt tgtttttctt atgacttggt tgactttcta 2550601 agctctatac ggtgcggcag ttcgacgata tgctcttcaa ccggctcttt attcatgagc 2550661 ttcgtcagca gtctcatcgc aacggcgccg atatcatatg tcggctgaac aactgttgaa 2550721 agctgaggac gaaccatgag gcttaatctt gtattatcaa aaccgataat gtcgagatcc 2550781 tccggaatgg ataagccctg atcctgagcg gcatggataa tgccgagtgc catttcatca 2550841 gttgcagaaa gaatggctgt cggtttttta tccaggctca tcagatgctg cagtgcttcg 2550901 agtccggaat catatgtgta atccccttca gctacaaatt gttcattaaa cggaaggttc 2550961 gcttcttcaa gcgcacgttt gtagccttgg agttttttcg aacggttgat cggttctgcc 2551021 attggtccgg aaacgaacgc gatgtctgta tgtcctttat caaccaaaag cttcacggca 2551081 tcataaatcg cctgttcgta atcgatagcg actgacggtg tttcctcctg ctcttctaca 2551141 gaagcggcaa gtacaatcgg cactggagaa cgcttaaatt ccgccacatg ctcgtccgta 2551201 atgtttccgc ccataaacac gatgccgtcc acttgtttgc cgagcattgt gtttaacaag 2551261 tgcagctctt tctccatgtt ttggtcagag ttgctcaaaa taatattgta tttatacatt 2551321 gtcgcgatat cttcaattcc gcgcgcaagc tctgaataga aaatgcttga gatatcggga 2551381 atgatgacac ctacagttgt tgttttttta cttgccagcc ctcttgccac cgcgtttgga 2551441 cggtaaccga gacgttcaat ggcttccaag acttttttcc tcgttgtcgg ttttacattc 2551501 gggttgccgt tcacgacacg ggaaacggtt gccatgctta cattagcttc tctcgctaca 2551561 tcgtagatcg taatattgct catcctaaaa ccactccttt tactggatac acttatcctt 2551621 atctatagca taaacacttt atgtagagaa atgtcataat gtccgaattt atgtcgttta 2551681 tgatttgtaa gcgtaagtca gtagtgtaca ttatttttca ttattcatca aatttaatta 2551741 cttctcatga aattatacac gtttttatag atgatgaaaa cgtatacttg gtttttataa 2551801 ctaaataaac gagaaagcat aaaaaaaggc cgcaggcgcg gccttttgga ttgttcaatt 2551861 aagcgttgac tttcaccatt ggcttcagtt cattcagcca tttttcgaat tcaggaatcg 2551921 ccatttgctg agcagagtca gaaagtgcga ctgacggatc agggtgaacc tcagccatta 2551981 cgccatcagc accgatcgct aaagcggctt tagctgtcgg aagcaagagg tcacggcggc 2552041 ctgttgaatg cgtaacatca acaaagactg gcaaatgcgt ttcttgtttc aaaatcggca 2552101 cagctgaaat atccagcgtg tttctcgttg ctgtttcata tgttctgatt ccgcgctcac 2552161 aaaggataat ttggtcattt ccttgtgaca tgatgtattc agcagcattg atgaattcag 2552221 agatcgttgc agcaagaccg cgcttcagaa gcactggctt tttcacggcg ccggccgctt 2552281 tcagcaattc gaagttttgc atgttgcgcg ctccgatttg aatgacatca atgtagtcca 2552341 gcgcttcttc gatatgagcc ggagttacga tttcactgat aaccgccaga tcaaattcat 2552401 ccgctacacg ttttaaaatt tgaaggcctt caacaccaag cccttggaaa tcgtatgggc 2552461 tcgtacgagg cttaaaggct ccaccgcgca aaattttaat cccttgtttt ttcgcagctg 2552521 cagcgacttc agctacctgc tcatagctct ctaccgcaca tgggccgaca atgaatcttt 2552581 gctggccgtc tccgattttt tcgcctttga tatcaacaat tgtatcttca ggttttttct 2552641 tgcgggagac aagcagcgct ttgctgtgat cttcttcctg aagctctaaa ccggctttga 2552701 atatctcttt aaaaatgtgc tggatggttg aattttcgaa cggcccgtca ttgttttcaa 2552761 tgatattgtt taacattgtg cgttctctga cagggtcaaa tcggttgaca ccctgtgctt 2552821 ccttcgcttt accgatctct tttacaacat tgccgcgttc gttgattaat tttaaaattt 2552881 gtaggtttaa ttcgtctgct ttctgcctta aaagctctaa ctctgtgttg ctcatttttt 2552941 tcatcctttc cctgcacatt cattttttat tttgtagtta tcatgcatct tactataagt 2553001 aattccaaat ggaaatactg aaatacaaaa aattttataa aaactctact ttattaccca 2553061 aacgctttta agtgataaag taatctatga agctatccta catgatgtga gggcaatgtt 2553121 caagggtttt ttacaaaaaa aagcgccaga tgatatctgg acgctttttt ctatgacaaa 2553181 tgctgctcaa tagcggcttc tgtaatttgt gaatgtgagg tatgccattt cacttcaccg 2553241 ttctggatga tgaatatctg agggctttca tgcttgaccc catatgtttc tgcaatgaaa 2553301 ttggacagcg gccgggcttc ttgtacttga agatagtaag ccggcacatc ctcatgctga 2553361 tttgcaaagg catcaaactc atgaaatgct gcctggctga tcgggcatgt ggtgctgtgt 2553421 ttcaagaaga cgaaaacgcc ttcctgttct gcaatccgtt taaattcttc ctcagattga 2553481 ataagctgtt tagccatgac tcaagctctt ccttccctgc tcagcgattc aactgctcag 2553541 cctgtttttg tgcatctttc agttcgtctt ttacatcttc tttcgtctgg aggacttgat 2553601 cttttgtttc atcagctgcc tgcatcgctt cttccctcat atcttgcatt gcagtcgatg 2553661 aatccgtttt gtcagatttg gaacggtctc tcaaatcctt taccttgttc atgatctgtc 2553721 cagactgatc cgctacaagc tgtgtgatgt tggaagtttt gtcttttgcg atgctgacat 2553781 attgcgtgcc tttttccttc gcatctgccg tcattttatc agttttgtcc cgtaaggcaa 2553841 cagcctggct gccgagatcg tcgcgaagtt ctttgcctga tttaggcgct agaaaaagag 2553901 ctgtagtggc accgatgatt cccccgatta aagttccgat taaaaaatct ttactattaa 2553961 ttccatcttt gctcatcatt attcctcctc ttagtatttt tttctcttac agggctgatt 2554021 ttttcttttg cttccatttc tcccaaattt ccattgctgc ttgactccaa gtgacaactt 2554081 gattgatctt atcttgattc tctctaactg atgccgatac agaccctgcc gcttgtttca 2554141 tggatgtatt gaactgctgt acagaagctc ccactccttg aacagcatga acgaccgtgt 2554201 tcagcttttc tgatttttcc tgaatatctt cagccaggcg gttggtctta tgtaaaagct 2554261 cggctgtttc agttgtgatg cccttcattt gtccctccag cccttcaaga gtggatgcga 2554321 cgttttttag tgtcagctgc agtgacttca atgttttaga caagtagatc actaatacga 2554381 gaaatgcaac tgcgatgagt gcaacgctca aataaagaat aataatcatc tcaaacctcc 2554441 ttgctgcagg atatactgct gtttacccgt tttcttcaat cataaacatg tgtactgggc 2554501 tgtatacata ctattctccg ttatgtaaga aaatccttta ataagctttc ccatcagata 2554561 aataaaaagc agtgagatca ctgcttttta ttatgccatg acgttttcgt aggctctcat 2554621 atatttttgg atatctcctg ctcccatgaa gatgagaacg gctttatcat gagcttttaa 2554681 aacagatgtg tcatcttctt caatcagctt ggcattatga atttttccct ggagatcacc 2554741 gatcgtcagc tttccggcat tctcacgggc tgagccgaaa atatcgcata aatacacaca 2554801 gtcggcgccg ctcaggcttt ctgcaaattc gtcaaggaac tgctgcgtcc gggtaaatgt 2554861 atgaggctgg aataccgcga caatttcccg atcaggatac ttctgtcttg ccgcctcgat 2554921 tgtcactttt atttctgtcg gatgatgggc atagtcatca atcagcactt gatccccaag 2554981 ctgcttctca ttgaatctgc gtttgacgcc cccaaaggat ttgagagcat gcttaatgat 2555041 gctggaatca atttcttcat aatggcataa cgcaatgacc gccaatgagt ttaatacatt 2555101 gtggtggccg tacgcaggaa tataaaacgt atcatagaac gtattgcgga caaagacatc 2555161 aaaagttgtc ccttccgtgc tttttacgat gtttctggct tgaaaatcat tttcttcccc 2555221 cgtgccataa tacacaaccg ggacgttcgc atggattttc ggcagatgct catcgtctcc 2555281 gcaggcaata atgcctttgt tgacttgaag agccatctct tggaaagcgt caaatacatc 2555341 gtcaatgctt gagaagtaat cagggtgatc aaaatcaata ttcgtcataa tcgcataatc 2555401 tggctgatag cttaagaaat ggcggcggta ttcgcacgct tcaaacacaa agtattcgct 2555461 gttttcattt ccctggcctg ttccgtctcc gattaagaaa gacgtcggtt ttgcgttttg 2555521 gatcacgtga gccagcagac ccgtagtcga cgttttgccg tgtgcgcccg taacggcaac 2555581 actcgtgaat tttttcatgt agtcgcctaa aaacttatga taacgtatca ccggaattcc 2555641 ctcagacatc gctttttcta tttcaggatg cgtgtctggg aatgcgtttc cggcgatgac 2555701 tgtcatgccg ggtttaatat tttccgcgct aaaaggaaga atcgtaatat ttcttttttc 2555761 aagcgctgtt tgcgtaaaaa taaatttttc gatatccgat ccttggacag tatatccatt 2555821 atcatgaagt atttgggcaa gcggactcat accggtccct tttattccaa caaaatgata 2555881 aacagtcata attgtacctc caacaaacgt ctatctgttc cccagtatat gacgctcatt 2555941 tcaatttgcg accgcggcgg ctgaaaagcc tcccttagcg gcgtatttta tatgttttgt 2556001 tatgtttagt atcaggttat ttctttccga ttaaacccag atatcaagat ttgtctatgc 2556061 acagctgctg taaagcggca tagctgttaa atgctctaaa cactatcata ccatgtttgg 2556121 tgtgaaaatg aacccatatt attcgtttat taaatcactt gctgtgatca gcacctctcg 2556181 aggcttgctt ccttttgcct cagagatcat gccttccgct tccatcatgt cgatcagcct 2556241 tgccgcacga ttgtaaccga ttctgaatct tctttgcagg cttgaagtgc tcgcactgtt 2556301 ttgctctaca acaaactcac acgcttcgta aaacagttcg tcctcttctt tcagggcaga 2556361 tccttgtctt acgagctctt cttgttcaaa taaataggtc ggcggcattt ggcttctgac 2556421 gtgggaaacg acgcggtcga tttcccggtc tgacacaaag ttaccttgca gacgaaccgg 2556481 ttttcccgag ccgttttcca aaaagagcat atcccctttt ccgagaagct tttctgcacc 2556541 ggctatatca ataattgttc gggaatcaac ctggcttgag acagaaaagg cgattctcgt 2556601 tgggatattc gccttaatca gacctgtaat gacatcgact gacggacgct gagttgcgac 2556661 gagaagatgg ataccgcacg ctctggcttt ttgggcgatc cgcgcaatgc tttcttccac 2556721 atcgtttgga gccaccatca tcaaatctgc aagctcatca ataatgacaa ctaaatacgg 2556781 cagcttttca cccatttggt gttcagcggt taattgatta aagcggtcaa tgtcgcggac 2556841 acctgaatgg gcaaaaagct catagcggcg ctccatttcc tcaacgaccc atttcaaagc 2556901 agccgtagcc gctttagcat cagtaatgac cgggctgacg aggtgaggaa ttttattgta 2556961 aggggccagc tctaccattt tcggatcaat cagcagcacc tttacctcac tcgggtcagc 2557021 tttataaagc aggcttacta atattgtatt gatgcatacg ctttttccgg agcctgtagc 2557081 gccggcaatc aagccatgcg gcattttctt caagtcgata acaacaggat ttcccgaaat 2557141 atctaatccc agcgcagctg tgagcggtga cttgcttgtc ctgaaagctg agctgcgaat 2557201 catttggcgc aaatcaacca ccttgctcgt gcggttcggc acttcaattc cgatcgtgtt 2557261 tttccccgga atcggcgctt caatccgaat atctttagct gagagactga gtttaatatc 2557321 atcggacaag ttggtgattt tattcacctt tacacccggt tcaggatgca cttcaaatct 2557381 cgtgacagac ggaccctggg ttacatggac cacattggcg cggacattga aatttttcaa 2557441 ggtcaaatca agaagctgac gctgttcttc gatccacgca gtatcatctt gaacctgcgc 2557501 tggcgggaca tcaagcagtg caacattcgg aaatacatag ctgccgcggc gctcctctgc 2557561 tttttgctgt ttatgcgtat ctcttttcag catcatcaca ttaaaaggaa cggatggccc 2557621 tttttgagaa gatgcgcttt gttcagtcct tttctcctgt acaccaggcc tttttttcgg 2557681 ctcttctgaa gcttcgcgag gtttgtctgc gcgaatttcc tgccggtttt caagagttgc 2557741 agtagacgat ttggaaccct gctccatgtg ttcagttttc tcaagctctg tatggctgtc 2557801 tggctgaaca tctatcttcg tttcctgagc ctctcccagg gtgtcataat gattatttat 2557861 tatgctttct gatggctctt ctgattcttt tgccacagtt tctgcttgag ccagagcctc 2557921 tgatgaatac tcatgatcag taaataaagg ctcttcctga cgaatgtcca tttgttcttc 2557981 ttgaacgaac ggggactcag caccttctgc cgcgttttca tgatgattgt atactgggct 2558041 gtctgacggc tcttttgctt tttcatcctc agatactgcc tctgtctgag attcaggagc 2558101 tgtttgctct tcatcaagtt cagcggagaa aacaggctct tcaaatttct ctggctgctg 2558161 ctccctttgt tcttcctcag ccgttgcagg ctcttcgcgg cctacttcac tgtctgaaag 2558221 cccttcagcc gccgtatctg tgagcatctc aggcggtgtt tgctcttcgg cttgttcagc 2558281 tgggaagaaa ggctcctctt tttccggctg ttgaacgcct gactcaaatg gcactttgtt 2558341 acctgacggc tcggctggcc gtttcgccag cgcctcatca tgctccgtat cctttctgtt 2558401 taaaacgcca gaaggctgtt tttcaaattg ggtatccggg aagaaaggac tttctatttt 2558461 ggaatgcgcc tgtgtgtctg aagcaggata gccgcgttca cgttcgatct cttctgacag 2558521 cagtgttacc ttctctttta ccgatttatc cggttcgttc aatgtttcag aaggcttttt 2558581 cggcacatcc tttttaacag atggtttttg attgaatcca tagacaggcg aagggatatt 2558641 tgtcggttta aacggtttct tcgccggctc tgctgcttga tatgtatgct gctcttcttc 2558701 atttctggga cgctctctgt aaggtgcagc acttggacga ggcgcggatt tcggttcgtc 2558761 cgatggtgtg cggcgccttc tcaggtcatg atttttgtat ccgtcaggca cgactggaaa 2558821 acggaatttg ccttttggat attcataata tattttagga tcttccaatc tttttaattg 2558881 tccttcagga tgatgtactt cttgttgctg cggaatttga gcgggttttg tctcccgttc 2558941 agcatcctct tcgctttcgc ctaaaaacaa atcaaaaaat ttatgaagcc aactcataat 2559001 ttatctctaa ctcccttata gttttctggg acggttttta gtataccact gctggtcggc 2559061 ccagaaaaga ttaagctatc agcagaaaca aagccgctaa acaagggctt agcggctttt 2559121 cacatgattc gttttttttg gcggatttat gggagtctaa aactgaaatg cgtctcccgc 2559181 ctcatagtct ccttctaaca caaggattcc tttttcagca ggggcatccg gcaaatcaag 2559241 ctctttcgct gagcagatca tcccgcttga cggaacgcca cgaagctctg catccttaat 2559301 gacaagtccg ctaggcatca cagcaccgac tttggcaacg acaacttttt ggccttggtc 2559361 aacgttaggc gcgccgcaga cgatctgaag cgtttcttct cctacgttga ctttacatac 2559421 gcttaattta tccgcattcg gatgtttttc ttttgattct acataaccca caacaaactt 2559481 cggagataaa tcaacgacta atgtttcttc aacgccgttt ctgtttaaaa tctcattcac 2559541 atcttgcacg aatgtttctg agagcgcaac agggccgttt tcatcaatgg tcaagtaaga 2559601 agacgcattg aaaatgttga agcccgttgt ttcttttgtt tcgttattga aaattttgac 2559661 gacgtcgccg tgtttttcat agcctaattg ttcgcgtgtc acatcttgaa gagagatcag 2559721 gagcgtgtct cccacacctt ctttattata aaaagcgttc ataagtaaaa atcctttcta 2559781 atcctttttc ggacggcttt tcgccaggat aaacaccggt tccagctttc cttcattgta 2559841 caaaaatgat agggcggtaa tcgggacggt gccgcctgca aagaagctca tcgacatttg 2559901 tcctagaata tcataccccg attcattccg gatgtcagca agaatcaaaa cgtcctgatg 2559961 aggaacagag atcgccagct caccttctgc atgctgctta tactcattta agatcgcttc 2560021 gttcaaaatc cggcttgcgt cgtatccgtc gtttgccctg aagaaataaa agtaattgcc 2560081 ggcaaccgta tcctctttga caaccgtcgg cagggaacgg agattaaatg cggccgtctc 2560141 tctgatccgc tcttttgtcc agttttcttt ctcaagcatg cgctggtcaa ttaaacggta 2560201 ggttttcccg agatctagcg cgtaataaat tcttgtctct gcggtatgat cgtcataaat 2560261 gagcgggata tcttcgctgg acttgtccgg gaaggaagtc gagcggatga ccggataaat 2560321 gcgagtttct ttcccggtca tttcctgagc cttcccttcc attgccgtca tcgcttcgga 2560381 gacatagtac acgatctcat caatggcttc gtcttttttc agttcccatt ttgcaataat 2560441 cggcggcaaa tcgagtgtaa tccctttttt agtcgtttga tcctcaacac ggagggtgtc 2560501 tttttctctg tcaaacagaa aggagcgatt ctcgtgctga aggcgctgct tcagtatatc 2560561 tgacagcttc cttgaggtca ttttcaaacc gatgtcctcc tttacgcttt agcgagagag 2560621 tctgttaaaa actgttcaat ttcttctttt gttttgcggt ctttgctcac aaaacgattt 2560681 acttcttttc cttcattaaa caccacaaag cttgggattc cgtaaatttc ccactctgca 2560741 catgtatcaa tgaatttgtc acggtctacg tagtagtagg tgaattcagg gaaattcgct 2560801 tccagttcag gcaggaaagg ctctacaaaa cggcaatccg ggcaccaatc ggccgaaaac 2560861 ataaatacag accaatcatc ctttaccgct ttttccagct cttgagttga ttcaattttt 2560921 ttcatttcat atccctccag ttgtttatgt tcttacatgt tttttatcga tactcgtcca 2560981 tttggatcat accaaactgc ttgaggcaaa accacttata tgcaacgaat gaatatgtaa 2561041 gattggcttt cccattatca ttatcatatt ttatttgcat tatcaagctc gtttcgttta 2561101 acatcgtgta catgagggtg aaatttacag atggatatac ataaggaggg atttttatta 2561161 tggagtttat cgtctattta gcaggagaaa tccacagcaa ttggcgcgag gaaattaaag 2561221 aaaaaacaaa atcactgaag ctcccgatta cgtttgttgg cccgatggag aatcatgacc 2561281 gctcagacaa tattggtgaa gaaattatgg gcgtacagcc aaatgccgtt ttaaaggatg 2561341 acaaagcctc tgacatcaac aacttcagaa ccgccgtcct gatgaataaa gcagactttg 2561401 tgatcgccct gtttggcgaa aagtacaaac agtggaacac ggcaatggat gcatcatatg 2561461 cgatcgcaaa aggaaaaccc ctgattatca tccggccgga atcgctccac catcctttaa 2561521 aagagctttc caataaagcg aatattacgg ttgaaaccgt taaccaagcc attaaggccc 2561581 tttcctatct atttgaaaca gaataagaaa aaagcttgtc gatccgggct tactgctcgt 2561641 tcaacaagct tttatgaaac ctacatattt tctttaatcg catccactgt ctgcttatcg 2561701 caggctgtta caagtttgat gagcatttct ttagcagcag cataatcatc aatatgaatg 2561761 atagtagcgt ttgtatgaat atagcgggaa catattccga taaccgctga cggcacaccg 2561821 ctgttcgaaa tatgaacctt gcctgcgtct gttcccccgc cggatacaaa atattgatat 2561881 ggaatatcat gcgtttcagc catatcaaga acgaattccc tcattccgcg atgcatgact 2561941 gtcgttctgt caagaatgcg cagcaaaaag ccttttccaa gctggccgaa ttcatttttg 2562001 tctccgctca tatcgtttgc cgggctggcg tcaagggcga aaaacaagtc cggtttaatc 2562061 atatgagaag ccgtctgcgc gccccttagc cctacttctt cctgaaccgt tgcacccgca 2562121 tagagtgtat tcggaagctc tttaccgtgt aattccttca gaagttcaat gcttaagccg 2562181 catccatatc tgttatccca tgcttttgat aaaattttct tttcattcgc catcgtcgta 2562241 aacggacaaa caggcacgat ctgctgtccc ggtctaatgc cgattttgat ggcgtcttcc 2562301 ttatcatccg ctccaatgtc gatcatcatg tttttgatat ccatcggtcg gtttcgctgc 2562361 gcatctgtca ataaatgcgg cggtatgctt gaaatcacac ccggaaccgg cccgttatct 2562421 gtttgaattt caacccgctg cgcaagcaaa acttggctcc accagcctcc gagcgtctgg 2562481 aatctgagca gcccgttgtc tgtaatggat gtcaccatga agccgacttc gtccatgtgc 2562541 ccggctacca taattctcgg tgcgtcctct gcgcctcgtc tgactccgaa aacacttccc 2562601 agtctgtcct gaacgatgtc atctgcatat ttggctagct cctgcttcat aaaagcacga 2562661 acctgatgct cattgcccgg cgcgccggga agctgcgtca gtgtttggaa aagcgctttc 2562721 gtttcttgat tcatgttttc ccctcatttc tatgtagtcc ttttatttta ttagaaacaa 2562781 tgaagttttc caagcactct gacccaatct gctcgatcag ccgcgtattg cttaacagga 2562841 tttggctgtt tctgtataat gaaaagtacg atcaaccagg aggtgcttta ttttgaaatt 2562901 gcgtcatctt cttttaggag caggacttgg aatttgtacg gctgtcgttg tgagacaata 2562961 tgtgatgaag ccttatattt cttcagaaaa agcgcttcga attgtaaaat ctgcttttaa 2563021 gcagcggggc ccgattgacg gatcatggat ttacacccag ccggagccct acaatattaa 2563081 cggagaaacg gtacaggtat acaaaaccgg cattacacga tcagctttcg gagaattaga 2563141 acagtatgaa gtcatggtgg atgcgaaaac gggagaaatt gttgatgtca ttgatacaat 2563201 cgcctcttaa caccggacaa gcaaaaaata gaagccgctg cctatgcagc ggctcttttt 2563261 tattatatcg cgcgaatcgg tttgtatacc ggataccaca tcgcatcctg cactgcctgt 2563321 ataatgtctt caggctcttc cgtagcgacg ccttccttca ttgcggtttt tgcaacttca 2563381 acagcaacgg ttgccgaaac agtgcgcaaa tcttcaactt ttggaagcat cggcgcccca 2563441 ggcaccccga cattgaccat acctgcgatt gcccgggcac atgcttcaaa catgccgtcg 2563501 gtaattaatt ttgattttgt aacaatcgtt ccaagaccga gaccagggaa gacaagcgcg 2563561 ttgtttgcct gcccgatatg atacgtaact ccgttatatt caactggcgg gaacgggctt 2563621 cctgtcgtga tcagcgcacg gccttctgtc cattcgatta aatcctccgg ctttgcttca 2563681 gaaagagttg tcggatttga cattggcaaa atcgccggcc gtttcacatg tgacgccatt 2563741 tcttttacaa tttcttcagt gaaagcgccg gaaaccgtag atgtgccgat caggatcgtc 2563801 ggtttcgcct gccgaaccac ttcaagaaga tcaatgcctc cgccgtctcc gttccgctga 2563861 taatccttca cttcatcagc cgaacgggca tacggctttt ggaaatcaag aagctgatcc 2563921 atatcatctg ttaacagccc gttcctgtct atgcaccaga agcgcttgta tgattcttct 2563981 tcactcagtc cctcgcgcac caatgcttcc cgcagctgtt cggcaattcc gattcctgcc 2564041 gttcccgctc cgaatataac aactctgtga tctctcagcg gaactttaga cgcttttgca 2564101 caggataaga ctgcggccaa agaaacagcg ccagttcctt ggatatcatc attgaaggta 2564161 cacactttat ctttatagcg tttcaaaatg cttcgcgcgt ttttcgcccc gaaatcctcc 2564221 caatgcagca atgcattcgg aaatgtttct ctcgccagcg caacgtagtc gtcaataaat 2564281 tggtcataac gttccccgcg cactctggaa tgctggttgc cgacataaag cgggtcgttc 2564341 aagaggctct cctgatttgt ccccgcatct aaaacaacag ccagcactct gctcggatca 2564401 atgcccgcag ccgctgtata aaccgccagc ttgccaatag aaattgcgat tcctccgacg 2564461 ccccagtcac cgattcctaa aattccttcc gcatcagttg caacaattaa atcgatcgta 2564521 tcgctttgat ctttatactg tttaaaagct tctttcatac cgtccgggtc atcgattgac 2564581 agatagagcc ctcgtggttt tctgtattca tggctgtatc tctgaattgc cgttccgact 2564641 gtcggtgtgt agacaatcgg gagcatttcc cctaaatggt catttaacag gcggtaaaac 2564701 agcgtttcat tccgatcgtg cagcgccgtt aaatagacat ttttgctcaa atcgtcaggc 2564761 tgtgcggaat attgttcata cgctcttttc gcctgatcat caattgttaa taccttgggc 2564821 ggcagaaagc cttttaaacc aagttctttt ctttcttcct cagtaaaagc aacacctttg 2564881 ttcaaaaaag gaacagagag cacttcaagg cctcttaatg ttgtttgaat gtctccttcg 2564941 tttgttactc tgaattgttt caccctgcct cttcctttct gagcataata gtactaggtt 2565001 tgcattatta gccggaaaac atgcagggta aacataaaaa tatgctatcg cttcattcgc 2565061 ttaactgact ttttgatgct tccgtcctcc tcccattgaa gggcgcgata ctcggcatca 2565121 tggtaaaaaa taaaccaagc atctttttct gctgcgaacg cctgccattt ctgcttttgc 2565181 gggatagagg tcatcggata atcatcgtaa gccagcaccc atagcggatt gcggtgggca 2565241 tgtgtcggca tcagatctgc catatgtacg gcagtttcac ccgcatcctc gcatatcagg 2565301 acactgtgtc cgtcgctatg gcctccggtg tgatgcattg taataccctc tgtgatcgtt 2565361 aaggtgtctt caaaggtttt gacttggcca gctacagcct cccaattttc tttccaatac 2565421 gtatttttcg acctgatatt cggatggcgc atttcgtccc attcaacagc tgatgtataa 2565481 atcactgcat tcggaaagac agagacgagc cgttcacctt catattccgt taaaccgcat 2565541 gcatgatcaa aatgaaggtg tgtcattgcg atcacatcta tatcggcaac cgttaatccg 2565601 agtgcagcta atgagggttt cacattcgac tcttgtgtca cgccatagtt tcgtttttgt 2565661 ttatcagtca gcttgccgta cccaattccg gcgtcaatga tgatattgag cccatccttt 2565721 tgaatcaaaa tagggtctgt tcttagttca atctggtttt tttcattgac tggatatttt 2565781 ttagaccaaa gcggctttgg cacaacgccg aacatggcgc ctccgtccat atgcgtcacg 2565841 cctccgtcaa gccaggtcaa cgtgatgttt ccaattttca ttgtttccat tttcaccccc 2565901 ccctatcatc atggtagcaa acggcccata aaaaaaacag actcctgtca gagtctgtct 2565961 ttacgttctc cattcaacct cagcccgata gatcggctgg ccgagtgcag agaatttttc 2566021 ttcatattct gtcataatat tgccttccag attgctgtta tgcaaatcga gactgacgta 2566081 tgtcagcagg aggccgtact cagagaagct cttcaaagag tactcaaata aacctcggtt 2566141 gtccgtttta aaatgaatcg atccgccttt gcccattact tcttcatatt ttttgaggaa 2566201 gtgggaatat gtcaggcggc gtttttcatg ccgtttcttc ggccaaggat cagaaaagtt 2566261 caagtagacc cgtttcactt cccccggctc aaacacatcc gtcagcgtgt ccgcatctat 2566321 attcagaagc tttacattct gcgcttcgct gtcttttact ttttggacgg ctgtcacgat 2566381 gacgctttta aataactcaa taccaatata attgatgtcg ggattttgtt tggccatacc 2566441 agaaataaat tggccttttc ctgtaccaac ctcgatatgg atcggattgt cgttgccaaa 2566501 cactgtgttc catttccctt tataatcagc aggattgctg atggcaatat ctgcgttttc 2566561 agccaaaaag tcatcagccc aaggcttgtg gcgcattctc atatgattga cacctctatc 2566621 tattatttcg actaacaaca taccatgaat taaaaagacc cgcaagctcg tttttccagt 2566681 gtatctctct taaggccgag cgcataaaaa aagagggtcc cgtctgctgg aacactcctt 2566741 tcccatgtat aaaaacgctc tgttttgaac aatttaaccc gtatgatact gaagggatgt 2566801 gtaccgttat gggtttacat tatgagcatc aagttcattt attgaaggat atattgactg 2566861 accatcaatt ggactgctgc ggaacagtcg cagagtacga gcagcttgag cgtgtgatta 2566921 aatcactgat ggcaaacacc gagcttgatt caaatttcaa aaacgtgctt gaagatgttt 2566981 accgctacag ccaatcagga atatcgtcca aatccatcga ctcacacata caagagcatc 2567041 agaacagcct gtctcaatgg gtagagcaaa tggattcgta ttcctgatta atcaacaatt 2567101 cgtttcatga ggatatgcag ctcttccatt gcatcatgaa attccttatc attgcctttt 2567161 gctttatgcc aggcaatgaa agtaattgtt tcagataaca cataccaagc cattcgcaac 2567221 cgaaggcttt ctgtcagctc tatgccgtac atgctcagcc agctctccca agctggcttt 2567281 tcgacgtagt ggtacagcaa aggcccgagg tccatcgccg gatcagcgat catggcgccg 2567341 tcccagtcaa ttaaatacag ctggttgtct tcagacaata gccagttatt atgattgaca 2567401 tcacaatggc aaacgacttt ctcaccgaaa tgcacttcat gcaggtgttc ttccaaatac 2567461 ttgatccctt cttgaatcag cggcgaagat tgctgcacag caaatacagc ctgcttcagc 2567521 tgagacaaaa gagcccccgg gttcagcggt tcttttccaa gtctcttcag catgtccagc 2567581 aaggcttttg atgtgtgtat tttacgaagc aattcagcaa cgggccgtcc gctcatgtct 2567641 ttaggcttca gctctctgcc ggtcatccag tgctgggccg taatgacgtc cccattttcc 2567701 atccgttttg tccaaaccag cttcggaaca atgccttcgg cggataaaac agctaaaaaa 2567761 ggtgagctat tacgttttaa aaaaagctgc tgcccgttat gtttcgcata atatgcatct 2567821 cctgtagctc ctccggcggg gaagatctcc caatcgctac ctagtaattg tcccaaccag 2567881 ttcatatcaa tgttcaaccc atcatttctt aaaatatttt agaattaagg ctaatcgttt 2567941 ctagtctatc cagcgaatgc ctttttcgta cgaatcgtat aaaaataaaa aagacagcta 2568001 ttgagagtct catatgctaa tcaatagccg tcctttaaat tttagcgcta tagcacaaac 2568061 ttcgtcaagc aaaactctta agatctgatg ctaaatataa gataaccgtt ccgatgccgt 2568121 ttactgcaac cgttttcttg atttctgttg ggtcttcctg aaatcctgat ggatcacata 2568181 aaagccgata aggtatgtcg tttggcagcc tccactcgac ggagtctgga ctcgcgtgat 2568241 ggataacaat gatatctttc cattcgtcaa cctcgtcaag atcataaagc ctgtatgcga 2568301 taaggtgttc ttttagcgtc aagcattcaa gatggcgctg gatgtctgca gcggacctaa 2568361 gacggaatgc aggatgcgct tttctcagcg agatcagcct gcggatatag tgaacatctt 2568421 ctttgaatgt ttcacggcga tcccagtcga gctggttgat gctgtcactg gattgatagc 2568481 tgttttccac tccctgcttc gtccggaaaa attcctggcc gctgtgaata aacggcaccc 2568541 cttgggcaag caaaataatc gcggctgcaa gcctttgcct gcttcgcttt cggctgtcat 2568601 tttcttgagg aagcgcaaag ctcattttat cccaaaaggt gtgattgtcg tgtgattcga 2568661 cataattgat ggactggctt ggttccggaa caatcggtgc taatgccttc catccggaag 2568721 acccggcaat tccatgcatc acagcttgtg ctgattcacc gttgccgagc gcaaaccctg 2568781 ttgccttaag gtgaaaggtg ttccctttta cagcgtcacg aaacatatca ttaaaaaagc 2568841 cgatgcccgg cattcttggc gcgttcgcca aagcagcttt ctgttcatgc ggcagcggtg 2568901 tagccaggtc ccacccttct ccaaaaagca ggattccggg ctttgcctta gttgctttct 2568961 ctttcatata aagcacggtg tcaatatcta aaatcccgag gagatcaaag cggaagccgt 2569021 caacattgta ttcttcaagc caatagacca cgcaatccgc aatgaatttt cttgccatcc 2569081 ttctttctga tgcaatatca ttgccaacgc cggtgccgtt tgatggcatc ccacattcgt 2569141 cgtgccggaa aaaataaccg ggcactgtct tttcaaaggg ggaattctcc ctcttataca 2569201 catggttaaa aacaacatcc agaatgactc gcagaccgtg ctgatgcagg gtattgatca 2569261 tttgtttcag ctctgttttt ctcgtttgag gatcatgagg atttgaggca tagcttccct 2569321 ccggggcaaa gaaatgaagc gggttatatc cccaattgta tgcatcaagc ggcttctctt 2569381 catcaactcc ggcaaaatca ttcaccggca gaagctccac atgtgtcaca ccaagctctt 2569441 ttacatacgc taatcccgaa gaactgccat ttgcggtttg tgtatcagtt tccgtcagcg 2569501 ctaagtattt tcccttgttt atcatgccgc tgttttcatg gatggagaag tcgcgaagat 2569561 gcgtctcata gatgacggca tccacagggt gtgagaatgg tttaagagga gcagtccatt 2569621 tcatttgatc cgggcgcaag acgacgccct tctctccatt tacagtcaca gccttggcat 2569681 actggtcaac tgtttccatc cattctgaat tgttgcagat gcaaaacaaa tactcatatc 2569741 cgtgaaggtc acctgtgacc gtgacggcat agacgccttt ttccaagcga gtcatttgga 2569801 atgtgcgccc gcttttattg gggtgtgaaa gcttgacagc agctgaggtt gcagcaggcg 2569861 cccatacttt aaatacggta tgatccgcgg tataaacggc gcccagctct ccgtcataat 2569921 aaaattcgtc atcaaacgct gccgtccgga tgaccgcgcc aatttggaga tccgttttgt 2569981 ggccgctgga tgctctgacg caatggattt ttccaaatgt cacaggatgg tcggatacgc 2570041 agacgtactt gtattttgct tcaagggagt attcctccct gacagccaga ggaaaatctg 2570101 ttatttctgt ctcaagccga aacggcggtg tcatgatttc cttttgttca gcaggaatca 2570161 gaacagtaat gatattcatg tcatcgacat acgcttcgaa gctgcggcgg atgctgacca 2570221 tcggaagctc tctcctccaa acacgtttat gttttgattc ttaggggtga aggactagat 2570281 gccagacgaa acggggtagt gcccatgatt tctccgtcag catggaacgg gattttgtcc 2570341 ttcgtgtaaa atgtaatgtc cttcgcttta aacatcgtaa cgccatccat ctttgtatgt 2570401 tttccaaatg ccatgagaca taaaagccaa tattttttca aaaacggctg gttttcaacg 2570461 attacgatat caaatgtctt ctcgcgcgga tttgctaggg gcgccgcctt catgcctccc 2570521 ccgtaaaacg gatggttgga tacaacggca aaccagacat catgaaattc gcgcgtctcg 2570581 tcttccgtcg tacaagctaa tgtaaacggc ttaaaggttg ccgaagcgtg caaatgagaa 2570641 agcggataca caagaaatcg aaggcggaga aaaagaaaaa cccgtctcaa cggaaattcc 2570701 atcgcctttt tattgacata tgcgtcaaac ccgatcccga tatgattcat aaaataaaga 2570761 atctgtgatt tatcctgaag gaaattgacg ctccctaaat gaaaggttct tgttaacggg 2570821 cgctttacct tcttgatttc ctgtatcaga tcgatttttt taatagagaa ccctcgcgaa 2570881 aaatcattat acgcgcccgc cggcacaaag ctcagctcaa tatcgtcaac atctttcagc 2570941 ccgttgacaa cttcatgcat ggttccgtct ccgccaatga cgatcaggcg cttcagctta 2571001 tattcctgta tcgttgaaat ctgtctggcg agcacctcgg cgtgtcccgg atgttcagtt 2571061 aaaaatgaac ggtgctcaac ctttcgtttg atcaattctt tttgaatgga cttccaaaca 2571121 cgcaggccgt ttcgatgtcc tgctgtcgga ttaataataa aaaaccaatg gctcatcttt 2571181 ctcacctgct tatgttatga gaaaaccgct caaatcgttc tcttttactc cagccactcc 2571241 tgtctgcgat aggagtcaga catgcagtaa gacaatagag cctttgcagc ctttacctga 2571301 tgatgtttga tcggagcagt gtttttcttc tgccgctcaa tccattcttc cgcgctccgc 2571361 ttatccgcta tttctaagcc gtatggcggc tccgggtaat cgatgtacga cgttctgctc 2571421 agaagcaatt ttcgaaccgg aatctcagcc tgtttttcct ttacgatctt tgacacaacc 2571481 gagtccgtac gaaacaggct aagccctgga tttaacactg atgcagtctg agaggctgtt 2571541 ttcttgtccc aaaaacgatt tttagaccct atgtagacac tgtcttcctc agcctctaaa 2571601 aaagaaacgc aataaatttc cagaggagaa ataatcacaa tgcttaattc aaccgccgcc 2571661 tgctgaattt tcagcacagg cttatacata ataaaataag aatcaggcag ctgctgggtc 2571721 agataacgca aaatgcggtc ctgcttcact tggtttgaga gttgagatat ttctgaaaga 2571781 gtagagcttg cccatttgag ctgaaaatca tataaatgcc ttttataaaa agaagcaagc 2571841 gccaccctgc tcttcgggag ccttacatga atatcttctt cgtcctcaaa ccattggtgt 2571901 ctctcttctt gtatatcggc ttttatctct tcttttcttc ttttcaatga aaattttttt 2571961 cgtttctgca ccggttccgg ttcttcagca ctggcttgcc tttcttcatg ctggcgctcc 2572021 gctgcttcta ctagtgaaag ccagcgctct tttttcaaac gtacaaactg gttgatataa 2572081 tggtacggat caagctcata tctcgatata taatcatgaa ttttgatgat ttgtgccatg 2572141 tttgtttctc cactccgcaa tgaattaaga taattgaaat ttgaatattt cctcgtattt 2572201 tggtgattgg ttcaagtgta tttgaaagag cgaaaatcgt tcagccatca tcgaaacctc 2572261 gccgctttca aacggaacat gagctggaaa tccatcttcg cctgtccatt ttcttgccag 2572321 cgtcatatga ggatgatacg gtcttttttc cacttgaaag ccggcctgaa gtacagcctg 2572381 cttcgtatgt tcccgcagtc tatcaagcgt tttgtttttc tttggctcca gatgtaaaac 2572441 gcgcggcttt ctgcggtcgc cgaatacatc tatcttgcca aacttaattg aaaatggatc 2572501 aatttctgaa gcaatctctg ctagcgaacc ttcaagcttc tttatttgtg tctcatccgc 2572561 cgctccgaga aaaattaacg tgatatgata gtcaagcggg tgcacccatt tttgaaacgt 2572621 caatatcggt tcgtttttcg cagcctggta gatcggattt gcaattccct caggtatggg 2572681 aacgccgatg aaataatgag gccgtatatc tggcatccgt ctgacactcc cttctttgac 2572741 agctattatt ttatcaataa agaggctgtg cggatagagg aacagtgtat gaaaacactc 2572801 tcgcacaaac gtttattatg ttaggatatt atatgacact tgttttattc agaaaggaat 2572861 gacaatgttg aaaatcgttg caaacacagc tgatctgata ggagatacac cgctagtgag 2572921 attgaatcgg cttcagccgg aaaatgcggc acaagtctat ttaaagcttg aatttttcaa 2572981 tccgagcggc agtgtgaaag acagagccgc ttatcaaatg atcatagaag ctgaacaaaa 2573041 cggtttactc aagccgggat cagttattat agagccgaca agcggaaata ccggcatcgg 2573101 gctcgccatg aatgcggcag cacgcggata taaagcaatc ttagttatgc ctgatacgat 2573161 gacgaaggaa cggatcaacc tacttaaagc ttacggtgca gaggttgtat taactcccgg 2573221 agaggaaaga atgccgggca gcatcaaaaa agcgaaggag cttgccgaac aaattccgaa 2573281 cagctatatt ccaatgcagt tcgataacac tgctaatcct gatgcgcacc gaaaaacaac 2573341 agcgcctgaa atcgcccggg caatagagga aatcggaaaa ccgctcggcg cttttgtagc 2573401 ctcctctgga acgggcggaa ccattaccgg aacaggtgag gcgctcaaag agctttttcc 2573461 ggatatcacg gttcatgttg ttgagccagc gggttcgcct gtattatccg gcggaaaacc 2573521 tggcgcgcat aaacttgtag gaacgagccc aggctttata ccgccgattt taaatgaaga 2573581 cgtttatgat gaaattatca aaatctctga tgaagacgcg tatacgacga caagacggct 2573641 tgctgctgaa gaaggaattc ttgtcggtcc ttcatcaggc gctgcctgct tcgcggcaat 2573701 cgaaacagcg aaacgcctct ctcctgacaa agttgtggtc tgcatgacag ctgatacagg 2573761 agaacggtac ttatcaactg atttatggtc atttatttaa aaaaaggact ggcttcagca 2573821 gaagccggtc cttttatttt gcaagctcgt aaatggcctg agcatataac gctgtcgatc 2573881 tcagcaggtc atcaatttcg atatattcat ccttttggtg tgcgctgtca gggcgtccgg 2573941 ggaacagcgg gccgaacgcg acaccggctt ttaaggatct cgcataagtc cccccgccga 2574001 ttgagattaa atcagctttt ttacccagct ggccttcata aaccttttgc agggttttga 2574061 ctaacggatg atctgcggac acgtgatgcg gcttgctgtc tttgaattct cccagctcaa 2574121 attcagatgc gctttcgaat gtatcgcgga tcactttgct ttctgctgtc acaggatagc 2574181 ggatattgat cccgagctcg cctccttgcc cttctttata gcgcagtgtt ccgacattta 2574241 atgtcagctc tccgctgatt tcatcctcac agtcgatgtc cagttttttt cctcttgtat 2574301 cacctgagaa cttatctgtc acaacttgca caaaccgctt tcctgcatcg tcaagctcag 2574361 tctgctggag aaattcgcac aataaaatgc cggcattgat cccattgttc ggttccatcg 2574421 catggcagga aagaccgtac atacgcaaaa tgagctgtcc gttctctatt gcagcttccc 2574481 ctttttggtc cgtcgtgcgg agcatgtctt taaatgaaga cagaatctct tcatttttcg 2574541 gcccttcaat gacagcttcc gcagcgtcgg gcaccatgtt taagcgaagg cctgattgaa 2574601 acgagacaag cactgccttt ggttcagctt gatttgggcg gtgcggaata agtaaagaag 2574661 catcgatgat ccctttttcc gcattaatga tcggaaaatc ggcgtcaggc gcaaagccca 2574721 ttgttggcat ttcttcatgc ttgaaataat gctctacgca tctccaatca ctttcttcat 2574781 ctgttccgat aatcattctg actcgcttgg acaggggcaa attcatgtct ttcacgattt 2574841 tcagcgcgta gaatgccgcc attgtcgggc ctttgtcatc aatggcgccc cttgcataaa 2574901 tccgtccgtt gcggatttca gctgaaaatg gatcactcgt ccacccatct cccggcggca 2574961 cgacgtcaac atggcaaagt acgccgataa tgtcatcgcc ctccccccat tcaatatgac 2575021 ctgcgaagcc gtcaagattt tttgttgtaa agccttcttt ttctccaagc tccagcaatg 2575081 aagtcaggct ggcatttacc ccttctccaa acggtttacc gggtccggcg gttgtttcgt 2575141 ccatgacact gttgattctc aaaaattcct gtgtatcacg aattaaatcc tctttttttc 2575201 tgatcacttc aacttcccag ttcataatga tcccctttcc gcaagaaatg acttgcaaaa 2575261 accaaataaa acgaataata ttaatggtgt tttgttaaaa cgttcgtaat tggaggatac 2575321 tatgtttcat ctaaaagagc agcaaacatc cataaagcaa gaaatcatag cagggctgac 2575381 gacctttttc acaatggtct atatcgtcgt ggtcaatccg gtcattctgg ctaacgccgg 2575441 ggttcctttc gaccaggttt tcaccgcaac gattattgcc tccattgtcg gaacgctgtg 2575501 gatggccctg gcagcaaatt atccgattgc tattgcgccc ggcatgggct tgaacgctta 2575561 tttagccttt catgtcgtaa gcgcaagcga tggcggcatc acgtacgcaa cagctttcag 2575621 cgcagtattt acagcagggg ttctcttcat tattctatcg ttaacgcctt taagaaaaca 2575681 acttatagaa gcgattccaa acaatttaaa atacgggatc acaacaggga tcgggctgtt 2575741 tattgctttt atcggtttgc gtcaagcggg aattgtggca gctgatgagt caaacctggt 2575801 cactctcggc aatctgcatt cacctggtgt tatcttaacg ctggtcggcc ttttgatcag 2575861 cgtggtcctg atggtgctga atgtaagcgg cgctttattt atcggaatgg cagctaccgc 2575921 tttgatcgcc tttttcaccg gtcagctcca tttttcaaag ggatttatgt cgcttcctca 2575981 tttgccggaa ggattgatga tctcaaatcc atttaccgct tttggcgatg tcattcatca 2576041 cggcctgtac gctgtcgtct tttcttttct attagtcacc atttttgata cgacaggcac 2576101 gatgatcgga gttgccgagc aagccgggct gatgaaaaac aacaagctgc cgaacgtgcg 2576161 aaaagcgctg cttgctgatt caaccgcgac gacagtagga gctgttttcg gcacaagtcc 2576221 gacgactgca tttatcgagt cttccgccgg tgtcgcagcc gggggaagaa cggggcttac 2576281 ggctttgact gtcgcggtga tgtttgcggc ttcaatgttt ttcagtccgc ttgtcagcgc 2576341 cttgtcaggt atagccgcca tcacctcgcc tgctttgatt atcgtcggca gcctgatgat 2576401 gggctcagtt tccaatatga actggaaaga gatggacgag gcatttcctg cgtttctcgt 2576461 cattctagcc atgcctttga cctcgagcat ttctacagga atcgcgcttg gctttatttc 2576521 gtacccaatt gtaaaagcgg cgcggggaaa atggagagag attcatccgc tcgtcatcgt 2576581 tttcgccatt ctgtttttca tccagctgtt tattttataa ggatagacca aaaaacccaa 2576641 acgtcgccgt ttgggttttt tatgtaaaca ataaagagac agcggccgct aaaaaacaac 2576701 aggcggcaaa cgcatagtgc aggatgttga tacagctttt tctggcccga taatattcat 2576761 cactttcctt atcggtgcca attaaaaaag gggcatccat gaccttgtca aaaataagcg 2576821 tcaggatata acggcaaacc cctgtgtata ccagcagcgc aatcaccttc agccaaattg 2576881 gggaaacaaa tatgagaaca gtgaaagctg acagtagcat gtacatctgc cttgcatact 2576941 cgccattcct cagcataact ttaaaaaaca actccttata gcctgtgcag atcgttcgtc 2577001 ttttaaatat cctttttgaa tttcggtata ataatggttt tcttctcatc ctgtctttta 2577061 cttttggcat tcccgcctcc tgactcatca tcatcacaag tcctgcaagg gcaagcctgc 2577121 tttttttctc ttcagtcacc tcagcttcaa aagccgtgaa cgaggctgtc tttttcaaac 2577181 tgcggataac tgagaaaaac aaaaataaaa tgccaaaaag cgcaagcaag tgccgctcag 2577241 taaaaacaat caggatagca gaaccagcaa aaagaatagc tctgacaagg gtatcgccaa 2577301 tccatctcga aatggagcgc ggctttctga tcctgtcttg ctttaaggat aaaaagaata 2577361 tatgaaggcc aaacaaataa cacaatagag cagtgctttc tgcgaatgtg atgagaacag 2577421 aatgactgat caagggaagg acaatgaaaa agagaagcag ccatttagcc agcgtggcca 2577481 gaaaagaata caaaagcgca taccgtttga gctgatagat gatttccttc ttttgcagca 2577541 aaaacacttt gtccgcttcc attaaaaatg tacgaatcga acctgtaaac atgatcagca 2577601 cacacacagc atacagccat ctccattccg ccacttcaga ccactcataa agaaggcctc 2577661 ttccgttcat caaatcaata tactgataga tgacaaaagc aatcgccggc aaaacgatat 2577721 agagagcgac tgtccagtca atgaccgcat gcaacacttt aaactgatac ttataatagt 2577781 caaacagcct tcgaaaaaag agcgtacgcc cgttcatagc cgatcacctt gaactgcctt 2577841 ataaaaacag tcaagcaatg actgcccctc taatccggtc ttgtcctgaa catcttttaa 2577901 cgtgccttgg agaaataatg aacctttctc aatcatataa aaccggtcac agattttttc 2577961 cgcggtatcg agtacatgcg tgcacataag aattccggct ccacgttctt tttcagcctt 2578021 aagcatgtcc acaaagcgtt tcgtcgatat cggatcaagg ccgataaacg gttcatcaat 2578081 cacatacata tccggcttag agagaaaggc ctggataagc attagttttt gctgcatgcc 2578141 cttcgaaaag gtgacaggca gctcatgttt gacatgatct agcgaaaacg tctgcagcag 2578201 gctttgggcc cgatgcgcaa attcactctc ttcaatgccg tgaagtgtgc tgatcagatc 2578261 caaatgctcc cacagcgtca gttcttcgta gaaggacgga tgctccggaa tatatgcaaa 2578321 tgaacagtcg ttccaggcaa tatgcccttt aaaatcttct gaaaggccga gtatcgcctt 2578381 gattgcggtg ctttttcctg cgccgttagc tccgatcagt ccaaccagtt ccccttttct 2578441 gacttccaga aaaacatcgg tgagcacttt ttttcggctt gtatacccgg cctgttctat 2578501 tgaagcttca agcaaatttg tcaaaactca ctcacctcca aaatttacta cgaaatagaa 2578561 taaaaaaagt ttctttaacc ataataatat tgagccgaaa tacatagtaa tccaacaagg 2578621 atggctgccc aacgcgaaat tggaaaaaat taataggagt tatccctaga ttcatcactg 2578681 caatatcgtg tataatgagg gcgaattatt ttaacaatta cagatgtctg cctttgttgc 2578741 tatttcgtac gcagttgata gtcgtgagtt gtggttagtc aagtccatcc gatcttatga 2578801 tagggagtgg ttttttgaaa ccttcaacaa accgtatgct aactcgaatc aaatcagttt 2578861 acatgtttat tcaagaaaaa ggtcttgtga caacacagga actggttgac gaattcggca 2578921 ttacacctag aacgattcaa agagacttaa atgtgttggc atataatgat cttgttcata 2578981 gtccaagccg tggcaagtgg gagacaacga gaaagaaagt aaagattacc tcataaattg 2579041 aaaattacat agggccgcct gagagcggtc cgatagataa cagggcgaag aaactactga 2579101 gccttgtttt tgtgtgctta taaataaaac cccgcattcg gtatgcgggg tttttgtcat 2579161 gcttgcggct catttagcaa atgaagctct tcctctgtca gctcacggta ttctccgggt 2579221 gccagagcgg gatctaggga aacgcgtccc atcgaaagcc gcttcagata aaccacttca 2579281 ttgccgactg cctttgccat ttgcttgacc tgatggtatt ttccttctgt aattgtcaga 2579341 tatataacgg tattgccact gtcgtttgtt ttgatttccg cttttgccgg ctttgtttta 2579401 tagccgccct ctatgtagac acccgtttcc aaatcggaaa tgtcttcccg agaaatctgt 2579461 gattttaaat ggacttcata cgtttttgga acatgctttt taggagaaag gagccgatgt 2579521 gcgagctggc cgtcatttgt gagcagcaaa aagccctctg tatctttatc aagcctgccg 2579581 gctggaaatg gctcaaatct catctcctcc ggcgtcagca gatcgaccac tgtttgctgc 2579641 cggctgtcct cagtcgccga cagcacgccc tgcggtttat tcatcataag ataaatgaac 2579701 tctcgataat caaccggttc cccgtatacg gtcacctcct gcgtatcagg atcaacgtgc 2579761 tcctttacat ctttggcagg tttgccgtcg atcatcacgg ctccagcctt cacaacggct 2579821 ttgacttctt ttctggaacc atacccgctg ttggcaagca gcttatcaag tctcattccc 2579881 aatctctcct ttataaaaga aagcccgcag catgcgagcc ctcagtttca tcatatctag 2579941 ttcatcagcc tgcatgtctg cctttcctaa agaaacctgg caaacggcgg cctaaaattt 2580001 tctgcaaaaa tcctaatcgg tagccgcaat acaggtagac agctccgcca acagcggccg 2580061 cgatcaccac aacaatcgca gcttgcatct ggccatcctg ataggaaata aagaagccta 2580121 atacccactg cacgattttc acggcaatac ccataatggc tgataagacc agcatcaaaa 2580181 cagttcgttt aacaagtatc ttatacgaat agcctgcatg gcgcttaatc atgataaacc 2580241 catataaaag ggaagcgata tatccaagcg ccgtcgctaa aatcgctccg tcagcctgca 2580301 tcagcttgat cagcggaaca ttcagcacaa gcttgatcac gacaccgatc acaaggctga 2580361 caaccgcaaa tttttgctta ttgatgccct gcagaatagc tgcgttgact gtaaacaaag 2580421 agaacagaat tgcgacaggc gaataccaaa gcaaaatgtt tgcccccagt tcaggatgaa 2580481 ggctctctga cccgtaaaag aacgtatacg tcggtcctga caatagagag atcccgacaa 2580541 cagccggaat aattaaaaac aggatcgtct gcatcgtttg attaatctgc tgatttaaca 2580601 gcttatagtt tccgcttgta aacgattcag taatcgttgg aattaatgtc agtccaaaag 2580661 cagttgctag ggaaaccggg atcatcacga gcttctgaac atacagggtt agaatcgcaa 2580721 gcatgtcctg gctgatggct tgatgaccgg cttcaatcat cgctttgtta aacgtatttg 2580781 tatcaatata gttatacaaa gggatggcta gtccgacaaa aacgtacgga gcagcatagc 2580841 tgaacagctc gaaaaacatt ttcttgtagc ttaggtttgc tgtcggaccc gtattcggca 2580901 tcatcgccag caggctgccc ttccgtttgt tccaataaat ataaagcacg accagccctc 2580961 cgaaggcacc gatcagcgct gcgaaggttg catagcccac agcgatgaca aggccgccgt 2581021 tgaaaacctt caaaatcaag aatgtcgcac tcaatagaaa gatgatgcgg acaatctgtt 2581081 caacgacttg ggaaacagct gtcggaccca tcatttggtg cccttgaaag aatccgcgga 2581141 caaggctcat aatcggtacg accaaaagcg ctaagctgac catgcggatg acataaacga 2581201 catgatcaat tgtcaggccg ttattatcct tgcctcccag cgatatttcc gcaaacatcg 2581261 gagccgatag atacagaatg aaaaaggcta tcattcctgt gactagcata accgacatgc 2581321 ccgccttgag cattttcctg cttgtctcat aatccccttt tgaattatat ttggaaacaa 2581381 atttagaaac agcggccgga aagcccatcg tagcaatatt caaaaataaa gtgtattggt 2581441 tgtatccgta ttgaaataat gcaccgcctg tcgccccgac cataatgctg aagggaatta 2581501 aatagaccat ccccagaatc cgcgatatat atgtaccgag cgttaataca aacgtgcctc 2581561 ttaacagttt gcttgacatg tttcttcatc accattttct acgaagattc aacttttcta 2581621 ttttaccaca actgggcatt tagacggtaa taaatacaaa agcaatcctg tgaacattca 2581681 tgtccgcggc aaaagacgtt taaggagcgg ctttctttcg ctataatagt actgcggacg 2581741 ggtgtccgca cacgaaatga aaagaaagtt gatgataaag atgaaacaat atgacgtaat 2581801 cgtaatcggc ggaggccctt caggcttgat ggctgcgatt gcagcaggag aacagggcgc 2581861 tggcgtgttg ctgatagata aaggaaataa attaggacgg aaactcgcga tttccggggg 2581921 cggccgctgc aatgtgacga accgccttcc tgtggaagaa attatcaagc acatccccgg 2581981 caacgggcgt tttttataca gcgcgttttc tgaatttaat aatgaggaca ttatcaagtt 2582041 ttttgaaaac ctcggcattc aattgaagga agaggatcac ggccggatgt ttcctgtgac 2582101 cgacaaagcc caaagtgtcg ttgacgcgct gttaaacagg ctaaagcagc tccgcgtaac 2582161 aatcagaacg aacgagaaaa ttaaatctgt tttatatgaa gatggacagg cagcagggat 2582221 tgtgacgaat aatggcgaaa tgatccatag ccaggcagtc attattgctg tcggcggtaa 2582281 aagcgtgcct cataccggaa gcacgggaga cggctatgaa tgggctgaag ccgcgggcca 2582341 taccataaca gagctgtttc cgacagaggt tcccgtcact tctggcgaac cgttcattaa 2582401 gcaaaaaaca cttcagggct tatcactaag agatgtagcc gtcagtgtgt taaataaaaa 2582461 aggcaaaccg attatcacac ataaaatgga catgctgttt acccatttcg gcctctcagg 2582521 acctgccatt ctcagatgca gccaatttgt cgtaaaagag ctgaaaaaac agcctcaagt 2582581 gccgatcaga atcgacttgt atccggatat caatgaagaa acgcttttcc aaaagatgta 2582641 taaagaactg aaggaagcac cgaaaaaaac cattaaaaac gtgctgaagc cttggatgca 2582701 ggagcgctat ctcctattcc tgctcgaaaa aaacggcatc tctccgaacg tatcgttttc 2582761 tgagctgccg aaggatcctt tcagacaatt tgtaagggac tgcaagcagt ttactgtcct 2582821 cgcaaatggc acactgtcgc ttgataaggc atttgtcacg ggaggcgggg tatctgtaaa 2582881 agaaattgac ccgaaaaaga tggcttctaa aaaaatggag gggctttatt tttgcggtga 2582941 aattctggat atccacggct acacaggcgg atacaatatt acctccgccc ttgtcacagg 2583001 caggcttgca gggctaaatg ccgggcaata cgcccgttct taatcattac tctttaaatc 2583061 tcttgccgcc aaactcacat ttgaacattc cccgcattca tgttagggtg agacttgttt 2583121 tgtttcacct gattgcgggg taattttaag agaggaatga gctgccatcg tacgaccata 2583181 ctaagcctgc gagcaagata taggcgtaca caaaaaatta gagggtgaga aatgttgaaa 2583241 catatatcta gtgtattttg gattgtgatt gcaatcacag ctgcagctgt attatggggt 2583301 gttatttctc ctgacagcct gcaaaatgtg tctcaatcgg cacaagcatt tattaccgat 2583361 tcatttggtt ggtattatct tttagttgtc tctttgtttg tcgggttttg tctctttttg 2583421 attttcagcc cgatcggaaa aatcaaactc ggaaagcctg atgaaaaacc ggaattcggg 2583481 ttattatcat ggtttgccat gctgttcagc gcaggcatgg gaatcggctt agtattctac 2583541 ggtgcggctg aaccgatcag ccattacgca attagctctc catcaggtga aacagaaacc 2583601 ccccaagcct tcagagatgc actccgctat acgtttttcc actggggttt gcacgcttgg 2583661 gccatttatg ccattgtggc attatgcatt gcctatttcc aattccgcaa aggcgcaccc 2583721 gggttaatca gcagcacact gtcaccgatt ctcggggata aagtaaacgg accgatcgga 2583781 aaggccattg actgtattgc agttttcgcc actgttgtcg gggtgtcaac aagtcttggt 2583841 cttggcgcaa cccaaattaa cggcggtttg aattacctgt tcggcattcc gaatgcgttt 2583901 atcgtccaat tggttttaat cattattgtg acagtgctct ttttactttc tgcgtggagc 2583961 ggactcggaa aaggaattaa gtatttaagc aacacaaaca tggtattggc cggattgtta 2584021 atgttgttta tgctcgttgt cgggcctaca gtgctgataa tgaactcatt tacagattct 2584081 atcggacaat acattcaaaa tatcgttcaa atgagcttca gactgacacc gaacgatcct 2584141 gaaaaacgcg aatggattaa cagctggacg attttctatt gggcatggtg gatttcctgg 2584201 tctccatttg tcggcatttt catcgcccgt gtatccagag gccggacgat ccgcgaattt 2584261 ttaatcggcg tcttggtgac accttgtatt ttgacatttc tatggttctc cattttcggc 2584321 gtatcagcca tggatctcca gcaaaaaggc gcgttcaatg tagcaaagct gtccactgaa 2584381 acgatgctgt tcggaacact tgatcactat ccgctgacaa tggtgacatc gatccttgca 2584441 ttgattctga tcgcagtatt ctttatcacg tcagctgatt cagctacatt cgtgctgggc 2584501 atgcagacgt cgtacggttc tttaaatccg gcgaattctg tgaaactcag ctggggtatc 2584561 attcagtccg ccatggcggc tgtgctccta tattccggag ggcttgccgc tttgcagaac 2584621 acagcgattc tggcagcgct gccgttttct atcgttatcc tgctgatgat tgcctctctc 2584681 tatcaatcgc tctcaaaaga aagaagagag atcaaaaaag cggagaaact cgataaacca 2584741 agaagtccaa gagtgaaaaa agcatattaa caaaaaagat ctttccgcgc ctgcggaaag 2584801 atctttttat ttgcgatata aaataagggc ggaaaaacag taaagctgct cgccgtctgg 2584861 gtcgcacgcc gccgaaaccg tatatttgat atctatcagc tgctcctccg atatcccttt 2584921 taaaaatgaa ttgatttccg tttgtaagtc tttttcatgc tcttcatcaa ataccgctac 2584981 cttcagcatt ttatccgctc tcctttctct atcaatctat tccgtttgga acagcgttat 2585041 gatagagaaa tgatgattat ctcgtttccg gataaaaagc tttccgtata tgggatttcc 2585101 tctgtggctc gccgccgtgc tgctccactt tcagcagcac ggcataaaca atgcgcatat 2585161 ggcagtagct gataaggctg acgctgaaaa aagggacaat gcccggcagg tacgcaagca 2585221 agaaaaagag agcaacagtc agcgcaagca tagtaagcgt atattgcaaa tacgccacac 2585281 tgagcaagag cgaaaatttc acatacagac gttttttcca gtcaaaatgg acaagcagcg 2585341 gaaacacata aaaaagcatg gatacgaaca aaaagccaaa tatcataatg gcgaagcgca 2585401 ggatgtgcag aaggaaatga cttggataaa ttaaggccaa atcaatataa atgatcactc 2585461 cgatgagcgc cagtacagcg ccgagcagat ttgaacgaaa aaattcaccc ttgtattcct 2585521 gccaaaacgt tttgagcacc ggaacgttgt cctgcccctg gatccacttc cgcatgacag 2585581 cgaataaagc cgcggtcgcg ggcatgatgc caaacacgcc gagaccgagc aacgtaaaaa 2585641 acagccacag caagtttgta tacgcaaatc tcataatcca ttcgcaaaaa cgcagcatcc 2585701 gtcccagtga gccatcatgt tccatggcgc cccctccttt tttgcattat acattctgca 2585761 tctgaaaaag ctctttcatg ccgatcggct tcttttcggc aaccgagcgc cacattccct 2585821 caccaaccgc gatggagtag gctccagctt cagccccggc taaaatatca tagcggcgca 2585881 gcgggtcttt ccctaaaaaa agatcctcaa gcaaaagcgg atcacctccg ccatgccccc 2585941 cttcattttt gaccacttgt atcgtctgct ttgattcaaa aagcggatag tattcgattg 2586001 tctgctcagg aaaagcaaac ggaattctgg aaggttcgtg aaattcattt gattcaatac 2586061 gtccttttgt gccgttgatc gtcagccggt agccttcata cggggccgaa aaaataatcg 2586121 agtagcttaa cagtgcgccg ccatcatatt tgactgccgc cacgtacgta tcctcgatgt 2586181 caatttcctc gtcaaaaata cacgcgtcag gcctgtatgc agtatataag ctggactggt 2586241 ctcctgcttc aagatgatca tcctttatag aagctttaga ggaacgggga tgccaccttg 2586301 aatagtagtg gcatttttct ttaacacggc acgtcccgca aaaacgcccg tcttcttccg 2586361 gcaaggggtt ccactcactg tccggcccat agtaattcaa ggcgccataa gcaaatacct 2586421 cttccggatt ttgcccgagc caccaattga cgagatcgaa gtgatgtgtt gatttatgga 2586481 cagaaagacc gccggaaaac tgtctcgacc tgttccagcg tttaaaatag ctggcgccat 2586541 gatacgtatc aatataccaa tttaaatcaa cagaagtgac cctgcctatt tttccgtcca 2586601 gaatcatttc ttttattttc cgatgaaacg ggctgtagcg atagttaaac gcgacggtga 2586661 cttttccttc gcttttggcc tccgcttcaa gcacccgatt cgcatcctgc actgttgtca 2586721 ccattggttt ttcagtaatc acatctgtat tccactgaag gctttttaca atatatgcga 2586781 catgcgtatc gtccctgcct gccacaatga cgatatcagg ctttgagacg cgcatcatct 2586841 cgtcaaaagc atcttcgcta aactcaggca cgtgggccag ctcgggaaat ttcttcttgc 2586901 aaacggcaaa acgtttcgga tcggcatcca gcaatcccgt aatctcataa tgagttgaaa 2586961 accgctccat cagtggtttg ataaacatac tgaatgctct gctgctcaat ccgcaaaaga 2587021 cgatgttctt caatatcctc acctctatcg ggcttcagtt agttgagaaa tcagctgcag 2587081 cgcttcctct gttttttcag catacacagg gataaacgcc gccatatcgc gattcaattg 2587141 aaaagaatag ccgttcagct gttttttccc tttttcgatc tgaacggcat agatcgtttt 2587201 ttctcctgtt tttttattaa cagttgtata aggagatgtt ttttcaggag gcaatccgtt 2587261 taacggctga aaattttccg gatcatcgta agcttgaaac atgtcttcag gcacgatgaa 2587321 aacatctccc tcatgggcgg taatttcagt cagcagtttt tcctgaaaag ctggaaagat 2587381 atcgaccttc ccggcattct gctcggcggc cttttttatt ttttcctgta cgccagcctg 2587441 catatcagaa aagagaatga catgcattcc gtccggcctg cttgagcatg atgccaaaaa 2587501 gagcactgag acgatcacac acaaagccgt acgtatcctt tttgtcattt ccccgctgac 2587561 ctaaaaagag gctccagctc tgtcatagct aaaataaacg cgccggctcc gtgcagatcg 2587621 tttgtgcttc tttcgcggct gacataatag tcatagaaac cggctgacgt tccgacacat 2587681 atgtctttga cgagaaacgc tccgtcttct gatgtttcgg ttttatgctg aatcaagcct 2587741 tgatacgctt ttagcagtgt tgtttcgtaa gctctgtcta gatagccttt attgattcct 2587801 tttgcgattg cgtacatgta cagacaggat cctgagcttt ccagccagtt atcagacctg 2587861 tctcccttat caacgatctg gtaccataac cccgtctctt tgtcttgata gcgacagatg 2587921 cttttaatca tgtcctgcag cgtgtttttc cacacatgac ggttcggatg cttcttcggc 2587981 agctcttcaa tcatgtcagc aagagacatg acgtaccagc cgatggaacg tgcccaaaat 2588041 tccggtgaac agcctgtctc ttcattggcc caaggcattt ttttcgcttc atcccaggcg 2588101 tgataaaaaa gtccggtttt tgcatccttc gtatgctttc tcatcaatga ctcctgaagc 2588161 acaacctgat caaacagctc cgtctcctgc ttcagattgg catatttcag tgcaaacggc 2588221 ccccccatgt ataagccgtc aagccacatt tggtaaggat aaccgtcttt gtgccaaaaa 2588281 ccgccctcag acgtccggtt cagtgttcca tataagctgc gcagcctttt tgccgctttg 2588341 acataccgtt catccttcgt ctgctcgtat aatggaaaaa gaatgagacc tgcttgaatg 2588401 gcgtccagtt catctcttct aaataataga ttgccattat catcgattaa gagatctgca 2588461 taagccttcg catactcaaa ataccgcttt tccccggttg cttcccacag ccgcaataca 2588521 ccgcataaga aaacaccctg atggtagtgc cagcggtttg caggtggcag ctcctcgact 2588581 gtgtacgtgt tcataatggt gtttgccaat gcctccgcgt acgtaagagg cgattttaca 2588641 gcgattgatt gatccattga tcccatccct ttcctaataa attccttcct cgccaaattt 2588701 cttcgccaaa cgattcgcta gcatgaccaa aatcagcccg accgccgctt taaatacgcc 2588761 gactgctgta ctgtagctga attggccctg tttcagccct gcagtataaa catacgtatc 2588821 aaaaatttcc gccacttccc tgttagtcgc atttaacagc aaatacacat gctcgaagcc 2588881 aagctccagc gtgtctccga ttttcaaaat cagcaaaacg acgataacgc ttttaatggc 2588941 gggcagcgta atatgccaca tttgccgcag ccgtcccgct ccgtccattt tcgccgcttc 2589001 atacagctgg gggtcaaccg ctgtaatggc cgccagataa atgatcgtcg accagcccgc 2589061 ttccctccag ataacctgca gaatatacag gggccggaac cattcttcgt tcagcagaaa 2589121 attgattttt tcaccgccaa aaaacacaat cagttcatta atcaagcctc cgtctaccgt 2589181 taaaagcaca aacgaaagcg atacaacaat gacccaagac ataaaatgcg ggatataaat 2589241 cagcgtctga acaaattttt taaagagagc aatccgcact tcgttcaata gaagcgccag 2589301 cagtatcggc accgggaaaa atatggccag gttcaaagca aataacacga gcgtgttttt 2589361 taacaagaga aaaaatgtag gctcagtaaa cagcctgata aaatgcttca gccccaccca 2589421 ctcactgccc aaaatgccga ggaacggctg ataatcctga aacgcaatca caattcccca 2589481 catcgggaca tacttaaaaa gcaaaaaata aatacacccc ggcaaaatca tcaagtacaa 2589541 atatttttgt tgaatcagct tgattagtaa gcgctttctt ttttcttttt taaaaatgac 2589601 tgcatcaaca gccggcgctt gcgcttctgc tgttttcatt ttttcctagc ctcctttcac 2589661 ggattcttgc attcactgta gcgcagcagg caaaagtccg tctacaatca tatgatcaca 2589721 tcctgtttta tccctttata atcaagggtt cagccggtcc acctgaaaaa aagacaccga 2589781 tattagaaaa tgattattga caatatctat caatctttgg attaattgta ttaaggtgaa 2589841 gtggatgtta tgaaatgggg ggttttatga aaagaagcca atacaagttt tactacaaac 2589901 tgatcacgtt tttctgcctg ctcagcacca ttccggttat tttggtcgga ttattttcgt 2589961 acgagcactc tcagaaaacg gctatttcca acgtttcgga ggaaaaattc gacacactcc 2590021 agcagaccca gcaaagcatc gagcatatat tgaaaaccgt cgatcactct ttaacccact 2590081 atgtgagttc gccgcctctc cttcgcacat tgtccgagcc tttgcactca gaccaatttc 2590141 aaatctataa ccaagtgaac caagagctca attatctgca aagctttgat accgatctgt 2590201 ccaacatgac gttagtcagt tatacgaaaa aatggtacat gaacaattcc ggtttgtacc 2590261 gtttgaatac agacactctt catgaagcag cctcagcgta cacgaaacaa aaagcgagcc 2590321 gctcctattg gacgcttgag gaaaacaatc atttgatttc aaccaaagaa ggcacagcag 2590381 aaaactgccg ctacaatatc aatttaatta agcagcttcc tttgaacagc acaaatacaa 2590441 agggattggc cgccgcaagc atcccgagct gttcgcttgt caaaaatatg cccggctatt 2590501 caaacgccaa caacctgttt atcatcgatg aaaaaggcct catcatcctt cataacaata 2590561 tgtctgacgt tggtgaatct cttcataacg acggctttgt ccaaaaagtg ctggcgcaaa 2590621 cggccaatag cggacagttt gaaacagtga ttgaccggat tcattataaa gtcacctatc 2590681 aaaaatctga ctataatgca tggacttatt tttctctcgt ttccctgcct gagttaaaaa 2590741 aagaagccaa atcaatcggc tggatcactt ttgcagtatg cctcattttg ttaacgcttt 2590801 cattgctgtt ctcttggctt ggctcccgcc atttttacaa gccgatcagg gtgctttacg 2590861 aatcattcgc aagacatgga gccatacaag agaaacaaca gcctcctcaa aatgaatttg 2590921 agttaattga acagagcttt aagcagctga aggacagaaa tgacgacctt gaagaaacga 2590981 tgaagcagca ggccactcat ctgcagcaat attttatggt caggcttatg cttggaaaac 2591041 tgacggatga ggaggttgat aaccgttttg aaagcctcgg cttaaagcaa aattggcggc 2591101 accttgccct gcttgtgctc caaattgaca cactgaatca tacgccttat gagaaaaaag 2591161 atatggatct gcttttgttt gccgtcaaca gcctgattga gcgcaacatc ccgacggaca 2591221 aacatcttgc ccccgccgta gttgacaaac agcaggcgac gattttgatc aatcaaagcg 2591281 ggacaaagga agaattcatg gctgagctga atgagactgc aaggatgatt caggaaaaag 2591341 cggaagctga gctgcagctg tctgtcagca tcggcatcag ccagccgttt gatgtgctga 2591401 caaaagcgaa aacagcctat gcggaaggct cagaagcgtt gaaatatcgg ctgaaagcgg 2591461 aaaacaagtc gatcatcttt tacgaagacc ttgaccagaa aaaaaccttc aaaacccatt 2591521 ttccaaagca gcttcagcat gagctgttcg atgctgtcaa agcaggagac aaggagaaag 2591581 cggataaatg cctgcacgcg attttacaag ccattttcac ccagaacacc aacccgtatc 2591641 aatttcaaat cgccatcgcc cgttttttga accatgtgat tgagctgatg catgtgcttg 2591701 ggatcgaatt gtttgagctt gaagaaaaca aaatgctgta tgaccaaatt tttgagctga 2591761 aaacgttcga ggataccgaa aactggctaa agaatgagtt tattgatccg atgacagaca 2591821 aagtgaacgc ccgcgcggat gcccagtaca aaaatatttc cgacaacatc attcatatca 2591881 tccatcatga gtttgaatcc gaattgacac tggacgaaat cgcacgcagg ctgcattaca 2591941 acccaaatta tttaagcagt attttcaaaa aagaaatggg aatttcattc agcgagtatg 2592001 tctcaagcta ccgacaccat atggcgaaaa gctggcttgc cgaaaccgac atggcggtca 2592061 aggacattgc cgaaaagctg aaatataaaa actcccaaaa cttcatcaga tcatttaaga 2592121 agctggaagg gattacaccg ggaaactacc gccagcaaaa aagaagcatg taaaaaaccc 2592181 aaaaccgctt gcgcgttttg ggtttttcca atgttatttt gcttgtttaa acgcttcttc 2592241 gtattcctga ataatttgtt ttcctccgct tgactcccat ttttccactt ctttatcgaa 2592301 ctggctttct gtgatgtctc caatcatata tttgtaggtc gcgtcatcaa tgattttctt 2592361 cagttcgtca ccccgttccg actccgatgc ggaatacagg ctttcagccg ggtttgagac 2592421 gataatcttt tcattgtcct cggtcagctc ctcgtacgcc gtccgaagcg gatctccagt 2592481 gttttttaag taggctttat caatggcaat taaagcggac agcggctgaa tatcagtctg 2592541 ccagtctttt acctggcttt ctttgcgtgt aaacgttttg tcctcacctt tgttgtaatg 2592601 aacgccgtca atgccataag tcatcaggct atagacatct tcttcggcaa ttcggtcaaa 2592661 aaacgccaag atccgtttaa gctcagcttc cgttttcaca ctcgttttcg ggaaagcaaa 2592721 cacgccgtta tggcctcctg atgcccatac ccgctctttc ccatctgggc cttttatgcg 2592781 gttgatgatc tcgagcttca tcgatttatc agaggcatgg tcgcgcagat tgaccgcatc 2592841 taccatattg ccaatataaa ttccggcttt tccttgagaa aacagctctt gctgctgggt 2592901 tttgcttgtg acgggaaaat ccttattcat atacccgtta tcacgcagct ttttcatata 2592961 gttcatcgtg tctttgtatt cctgtgtcat gaaatcaggc gtgaatttgc cgcccgattc 2593021 cttccaatct gtcggcatgc cttcatacga gccaatcgtt ttaaacgcgc cgtaaatcaa 2593081 gtcattacgg tctgccagcc cgaatgtatc atctttccca tccttgtccg ggtcgtcctc 2593141 cgtaaatgct ttggccactt cataaagctc atccaacgtt ttcggggttt tcaaatttaa 2593201 attgtccagc cagtccttcc gaatgacgat cccctgtctg gaaagcgggc gctctctgta 2593261 tatcccgtag agcttgccgt caattgtcac atttttatta atgagtttgt tcattttgtt 2593321 taagttggga taatccttga tataatcgcc gatttcccaa aacattcctg accgaaaggc 2593381 attcatgact gacgaatttt taatatcctg gatggtcacg atttgcggaa gattgccggc 2593441 tgcaagcgct gcattcagcc tgtcttcttt caccgcgtct ggaacccagg tgatgtcgag 2593501 ttctgtattt gtcagctttt caatttcttt aatcgccctg tctttcggcg gctgctggtg 2593561 atacaaaatc gccatccaag acagctttac ctttgaatct gggccagctt tgccttcagc 2593621 cgaagactga tcagttcctt tacagcccgc cagcactccg ccgagtgcca gtacaagcac 2593681 aatcaaaagc accctccatt tgtttcccat cgtacccctc cgtttcatat ttctttatcc 2593741 tttgacagat cccagcaaag ctccttttgc aaaatgcttt tgtataaacg gatagacaag 2593801 cagaacaggg atggtcgcca ccactatgac cgccatttta atggtttgct caggcggcgg 2593861 gctgcccgac cccatttcag acatatcccc ctgcataccg cttgatacaa tgacgatttg 2593921 gcgcagaagc acctgaattg gccattttgc tgaatcattt aagtacaaga tcgctgtcat 2593981 atacgtgttc caatacgtga ccgcataaaa tagtgaaatc gttgcgatcg caggaagaga 2594041 cagcggcagc acaattttaa agaatatgcc cagatcattg cacccgtcaa ttttcgcgga 2594101 ctcttccagg cttgacggga tattttgaaa gaagtttttc agaatgatca ggttaaaggc 2594161 attaatggct gtcggcaaaa taagcgccca gtaagaatcg agcaatccaa gcgatttgac 2594221 cacaaggaaa gtcggaatca tgccgccgct aaacagcatc gtaaatacga cgagaaacat 2594281 gagcggctgc cggccgatta aatcacggcg ggataacccg taagccatca gtgacgaaag 2594341 aaacatgctg accgcagtgc ctatcactgt cacaaacaca gaaacaagca aactcttata 2594401 aataatatct gttgaaaaaa tgtagcgata agcatctagc gaaaaagtgg tcggtattaa 2594461 aataaatttt ttcgacacga cttcttctac tgtggcaaag gatgctgcga taacatgaat 2594521 gaacggaagt acgcatatta aagcgaacat cagcaagaaa ccataaatca acatatcaaa 2594581 cagacggttt ttcagtgaat gtgcgatagc tcccacctcc ctttgtaagc gttatcatat 2594641 ttttggaaac cgagctcagc atgtgacgat atcgtgtcta aaatgtagca aatctgtgat 2594701 tgccatgtct ataatcattt gaacagtgtc cccggccggg cgggggctgc cgcgaattga 2594761 gaccgataac aaaagaaaaa gagcataatc ttagaaaatg attatgctcc gttctcctcc 2594821 tcgttcagaa gttcagccgt attgatttgt ggcgaaaacc caagttcatt cacggcagat 2594881 tcaatggacc atggccggcc cggattatca gagacggcgt aataagtgcc ataccggatg 2594941 ttggtctcaa tggcggcttt gaaaatcgac agcagatcgg ggtgagaaag cagtgtcttt 2595001 ttcgtccgtt ctttttcatg cagcgtatcc atttcatctg tcacgactgt tccgattcga 2595061 aggttgatta ctgatagctt attttccaaa taaaacaaat ggccgatctg ttcagaggtc 2595121 agctttaata caccgtacaa gttttttgac agcggataat cgcttgttgt gatttcccgt 2595181 cctaagagcg agcgcccgtc tttttcatat acatctgtga catgattgct gctggcgaac 2595241 acgagctttt gaatgccgag ctccgctgcc gcacggcaca gataatagct tgccctatag 2595301 aaaacatccg tcattttttc aaactcagcg atgtccataa tatcgtattt gattttcaca 2595361 gcgagtaaat tcaagatggc atcggtatct tttggaatct tcttcaacag ctcctcataa 2595421 tttgccgcgt cagcctgaat ggaagaggct ttgccatcga aatgatcttt atcaagcaca 2595481 gtcacttcat agtctgaaat aagcccttca gcaagcagtc tcccaatcac accatttccg 2595541 ccggcgatca gcactttttt cacgatgttc actccccttt tttatagatt gcccattttc 2595601 ggcggggctg acactttttt ggcactcaca ttcttaggct tattcaaaag tcaccggcag 2595661 ctcctcaagc gcccgaaatc caaaaagcgg ccgataccgc cattcaaaat ccgcaagatt 2595721 aaggctgggc attcgctgca gaagagtgtt aatcgcaatt tgcgcttcta atcgtgccag 2595781 cgaggaccct aagcaaacat gatggccatg cccgaatgaa agatgcggat taggacttct 2595841 cgtaatatcg aagacatcgg ggttcgtgaa tatgctaggg tctcgattag ccgctcctaa 2595901 caaaagatag acttgttctc cttgacggat cgtcaccccg cagatgtcaa tatcctctga 2595961 cgcaactctg gctgtcattt gcgtggggct ttcatagcgt aaacattcct cgactgcggt 2596021 accaataaga tctggatttt ctctcagttt caaaagctgt tctggatgct gcagcagaca 2596081 aaggactgaa ttgctgatga gattgaccgt tgtctcatgt ccggcgatcg ccagcaatat 2596141 gcacgtagat gccgcctcct cttccgtcag cttatccttt tctctcccct tcaagagcat 2596201 gctgatcata tcctgttgag ggtggcgttt tctcttttga atcagctctt tgaaatatgc 2596261 catagcctgc acagccataa tattgccctc tgttaatgcc tttcttgagc gggtaaaatc 2596321 aatcgtttga atgagactcg cagcccactc ctttaattgc tccctatctt cctccggtac 2596381 acctataatg ttagctatga caaaacttgc taaaggaaaa gcaaagtccg aaatgacctc 2596441 catctttttt ttaccttgca cttgatcaag caaatgatgg acagtttcaa tgatatacgg 2596501 ctgataactc tctgtcgttc tcggcgtaaa cgctccgctg gcaagcgtcc gcaatcgtct 2596561 atgatcaggc tggttctgaa acagcatcat ttgattttgc acatgtgaaa ggtcctgata 2596621 tttggttgag ctctcaggca gcggggtgcg gactttgaat ctcgcatctt tcaaaatagc 2596681 agccgtttct tcatatcctg tgacatacca gcccgggtat tttaagaaac tccctttata 2596741 gataggatga acagctcgca atgtgtcgta aaaagaatat gggtttttca aaaactcaga 2596801 agatgcagtt gacgatgcaa ttgtcacgtg attttctcct ttctgttcaa aaataaaaac 2596861 aatcgacatc ataccgattg cttttattga ttctttcagc ttttcgcact taaactagcc 2596921 ttcatttctt cgactgattc aacttcaaag cctaaatcac tcagcatttt atgatcctcc 2596981 gtctcctctt gcccggcagt tgttaagtag tctccgacaa aaatggagtt tgcggcgtaa 2597041 agccctaatg gctgcaatgt gcggagattg acctctcttc ctccggaaat gcgaatttct 2597101 tttgatggat tgataaaacg gaacagcgcc agcactttta aacaatacag cgggtttaat 2597161 tcgttgacgc cttctaacgg cgtgccatca attgcatgca aaaaattcac aggaatggaa 2597221 tccgcgtcaa gagccttcaa gcttttggcg atgtcaatga catcctgttt cgtctccttc 2597281 atcccgataa tggcgcctga acacggagac agccccgatt cttttgcgat ttcaaccgta 2597341 ttgactctgt catcgtatgt atgtgaggtt gtgatgtttg aatggtttct ctgtgacgta 2597401 ttcaaattat gattatagcg gtctactcct gcatctttga gccgcttcgc ctgctctggc 2597461 ttcaacagtc caagacatgc acaaatcttc agtccatacg tctctttaat ttcctgaacc 2597521 gcatctacga cctgatccac ttctctgtta gacggacctc tgccgcttgc cacgatacaa 2597581 tatgtgccga tattcagatc gtgcgcccgc ttcgcgcctt caagcagcgt ttccttattc 2597641 accatccggt aagactcaat cggcgctttc gaaatcgcag actgtgaaca atagccgcag 2597701 ttttccgggc agagcccgga tttcgcattc ataatcatat tgagctttac tttttttccg 2597761 taaaagtgtt ttctgatgtg aaaagccccg tgcattaata gcaaaatatc ttcatcagga 2597821 caatgtaata ttgaaagcgc ctcttcgtca gtcacttctg ctccagccag cacccggtct 2597881 gcgagttcca tccattgatt cattctcata cccccacttg attcatcagt aatgatagat 2597941 tgatatggtc ttttaccata tgtagaaccg tttctttcgt cacgttggca agctttggcg 2598001 taacccctaa aatcggcaca ccgcataagc gctcaatcat ctcaggattg gttttttcat 2598061 cttcatcagg agagtcactg attccattga tgataattcc ggcgattgga agccccatgc 2598121 tttctgcata tttgacagtt aaaaaggtat gattaatggt tccaaggcga ggacgcgcca 2598181 caataatcat gggaagctgc aacgctttta tgacatgact gaccaaatag tcctctccca 2598241 atggcacaga aataccgcct gcaccttcta cgatgaagca ttcatgtttt tctctaatcc 2598301 gcccccaatg gcttaaaacc tcttccatgg tgacagtctt tccctcaagt ttccctgcaa 2598361 cgtatggtgc aagcggcgcc ttgaaggcaa aaggcgtaat gtcttcatga gaaagactgg 2598421 tctgcgacat atctttcagc aaacttgtat cactatctgg atgatggcgc gatatcccgc 2598481 ttaaaaatgg tttatacacc ccgacatgtc tattattgtc tttcaataag gcagcaagac 2598541 cgctggatat aaccgttttc cctacttctg tatcagttcc cgtcacaaaa aaacccctca 2598601 aatgatgtgc agctcctttc cgattgaatg aaatgtttgc agcaaatgat caatatcacc 2598661 catactgtgg tcagacgtga ttgtaattcg aatccggctt tcacccggcg caacggttgg 2598721 cggccgaatg gcaggagcat aaattccctt gccctgcagt ttttcagcaa ataggaccgt 2598781 tttatgggca tcgccaatga ctacaggaat aatcggtgtg tgatctcctt tcaccacata 2598841 acccatattc ttcagactgg ttctgatcat gctgatataa gaaaataaaa gctgtcgttt 2598901 ttccctgctg gcttcaatga tgttgaaagc ctcgtgagca gccgcacagc tggctggcgg 2598961 aatagcggtt tgaaagataa atgttctggc atggttcagc aaaaagtcga tgaagaccgc 2599021 tgatcctgcc gcaaaacctc cttccgcgcc aacagctttg cttaaggtgc cgataacaat 2599081 gtcgggacaa acaccaaagt attcactcgt tccttgtccc gaatcgccca aaactcctgt 2599141 tgcgtgggca tcatcaacga ccacgaaggc atgatagcgt ttcgcaagtg agatgatctg 2599201 atcaagaggg gcgattgtgc catccatgct gaatactccg tctgttacga taaaacggcg 2599261 ctgataacgc tgtgtttcat tcagcttgtt ttcaagatca ttcatatcaa tatgccgata 2599321 aacaactgta tcagccttag aaagtcggca gccgtcgatc atacttgcat gattgagctg 2599381 gtcacttaaa atgacatctt ccttttctgg caaggatgaa aggacaccga cattggccaa 2599441 gtaaccgctc gaaaacagca gggccgcttc tgtcagttta aagctggcaa tcttcttttc 2599501 tagcttttca tgccagaccg aattgcctgt cgttaaacgt gaaccgctgc ttcctgtccc 2599561 aaattgctgc aatgctgttt gggctgcatc gatcaaacgt ctatcgcttg cgagccctaa 2599621 ataattgttt gaggaccaga ccgtttgatt ttcgccatca atattcctct ctggaaccgg 2599681 cgctccatcc attgaccgca ggttacgatg tacgccggct tctttcattc tgtctaaccg 2599741 ctcgtttaac caggaatcaa tcttcaaggc tcgtaacctc gtggatcgct tgtttcataa 2599801 tggcaaccat ttccgagagc tcttcagctg tgctggcaag aggaggaaga aatgcaatca 2599861 cgtccccaag cggtcttgtc agcattccta actctctcat ttttaaggaa actttgtatc 2599921 caatccgccg atcagccggg taaggttctt tagtttcctt tgatcgtaca agctctgcac 2599981 cgcacataaa gccaagctgc cgaatatccc caacatgagg aagagcgtgc agatcttgaa 2600041 gaagaaaatg gagcttttta cttttttccg ctacttgttc cacaatgttt tcagattcaa 2600101 ataatgccag attttcaagc gcaaccgcac agccaagctg attgcctgta taggaatggc 2600161 catggaaaaa ggtttttagg ttttcataat catcatagaa tgccttatag atgtcttcag 2600221 tggcaaacgt aacggcaatt ggcaaatagc ctcctgtaat gcctttaccg gcagccatca 2600281 gatcaggctg gacattctcg tgctcgcacg caaacatttt tcctgtacgg ccaaagcctg 2600341 tagcgacttc atcaacgatc attaagacat cgtatgttgt acatagctcg cgcacgcctg 2600401 ccaaatatcc ttccggcatc acgatcatac cggacgcgcc ttgtaccatt gattcaatgg 2600461 aaagcgcggc aatttcctca tgatgttcct caagcagctg tgcaagctct cggaggcact 2600521 gatcacggca ctcatcagga tcaccgcttt cagaacgata cacataagga atcggggcct 2600581 tgtaactctc gaacatcaac gggccgtata cgtggtgaaa aagctcaatt gaaccgacac 2600641 tgacggcgcc aatcgtatca ccgtgatacc cgtttttcat tgcgatgaat ttttgtttct 2600701 cgggcttccc gatgttcttc caatactgaa acgccatttt tagggctatt tccatcgcct 2600761 ctgcgccgct gtctgaataa aagacccgcg tgagcttttt tgggctgatg tcgattaatg 2600821 tttcggcaag ctgggttgct ggaacattgg tcatgcccaa taacgtggag tgcgcaattt 2600881 ttccgagctg tttttttatg gcgtcatcta gttctttttt gcggtgtccg tggacattaa 2600941 gccaaaccga tgaaaaaccg tcatagtatt ccttgccgtt tatgtctttg actttgattc 2601001 cagtcccgct ttcgatgatt aaggggtttt catcataatc tttcatttgg gtaaatggca 2601061 gccagaggtg ctttttactt ttttctatca aatcatgagt catgatcttc ctcccactct 2601121 attaaaatag gctgcttctc caggtcatgt atgtacgtgt ttacatcatt ggatccatca 2601181 ataaaaaaga ctcggcagcc ctcttcagtc ccgtattctt tcattgctgt aatacgctga 2601241 tagcccattt tcttacccgc aacatagcct gttatgtaat ccggatcgtc cgaccagcat 2601301 aattctgcaa cgactgccgg gtgccggctt acctttgaag cgagcgcaag ggcctctttt 2601361 attcttgaat gagctggcac gtgactgtga agcgcccatt tttcaaaatt agcgtccggc 2601421 caatccattc tggagacccg cacccctttt tcttttgttt gatccattcg cttgcctgta 2601481 tgaatatcaa acaacaccgc acccctgaca tctgaccatt cagggatttg ttcatatgct 2601541 ttttcaatca cgtctcgtga aacgccttct ttttccaata acaatcgggc aagcttttgt 2601601 ccttcttccg ggcagctcac ttcattcgta tgcacaggca atggctgaat ggtttttatc 2601661 gattcatgta cctcttcaaa ttgaatttgc ataaaatcag gttttcctct tgaatgggat 2601721 aacccttttt ctaataaagc attgactgta tgcttcatct catggaaagg aataagccgt 2601781 tctccgccgg atatatgctt tccgccgtct tcatgagatc cattcattga agccctcatt 2601841 ctgacactat aaaaagtttc ttcttgcatc atttctcgcc ctttcactga taactgaaga 2601901 acgtgtagcg cttctcacct aaattgttaa ccaattatat tcaaaggtta acaattagaa 2601961 tatattattc tctcctgttt ctgtcaatag aagaaaggat cgatttatgg cagttggtta 2602021 aaaggaaaca aaaagaccgt tttcacacaa aacggtcttt ttcgatttct ttttacagtc 2602081 acagccactt ttgcaaaaac cggacagctt catgccttat aactgctgtt tcgaaatgtc 2602141 ccgaagcaga acggaccact cggtagcaat cagcagctcc ctgtccagca tagacagctg 2602201 tcaattcttt ttcgattttg tccacgccct cagccggcgt taaccgatcg tgtacaccaa 2602261 caagactaag gtgcgggcgc ggcgcgatca ggctttggat ctccgatgcg gaaaaatgct 2602321 ttgcaagcga tgggacgtaa taataaaagc cgtgcctgtc aagattctgt gttttgatca 2602381 gcacgtgatg atccacctgg ctgcacaaat ccacacacac cttaatccgg tcatcgagcg 2602441 ccgctgtcca ccacgccatc aaacctccca tagacatgcc gatggttccg atcctgtcag 2602501 gctgaacatc agagcgtgac tgcatatagt ctaacgcact taaactgtca taaatcatca 2602561 tcccccacat cacttttccg gtgagaagca tttctttaaa tatctcgctt tccgcttttc 2602621 cccgccgatc tccaaacccc caatgatcaa tcgcaagaac gccgtatccg agtgaagtaa 2602681 gctcatcaga aaaagaaggc gttttcaaat aatccgctcc ctcaatcagc tcactttttc 2602741 ccctatcata ctggcctcca tgcgaatgct gaaacaatac ggctgggcac ggtccttctg 2602801 ttttcttcgg cttcacaaaa taagcgggcg ccttttcatg tccatttaaa tcgagcagga 2602861 gcgtttcaac gatattttct tctctttctt caatacgtaa tgtctcaaca ctgattggcc 2602921 tccgatcagg caaatcacca agcaatcgaa acagttgctt tcttctttcg gctctcatcc 2602981 catcaccctt ccttattcgc ttacttcaca tttacgagac agatctgggt tcccctttat 2603041 ttttccaaca taaatcacat catttactaa atatttagta aatattatgg aatatttcga 2603101 aaacaattat tgtaaccgct tacttttata tgataatatc aatttatcaa aaacagatga 2603161 gttaatattt tactaaatag atgagaggga tacccatggt tcgtattaaa gatatcgcct 2603221 tgaaagctaa agtttccagc gcaactgtgt ccagaatttt aaatgaagat gagtcgcttt 2603281 ctgttgcggg cgaaacgaga caaagagtca tcaacatcgc tgaagagctt ggttatcaaa 2603341 ccgttgccaa acgccgaaaa tcccgcgggc aaaaacagcg ggctcagccg ctgatcggtg 2603401 tgctgagctg tctgtcccct gatcaggaaa ggcaggaccc ttatttttct tccattcgga 2603461 aagggattga aaaggaatgc tttgaacagg aaattttcat tacaaattcg attcatctcg 2603521 gctcctttca ggaacatatc tttcgggaat tggatggtgt cattgtcatc ggccgtgttc 2603581 atgatgaagc ggttaagcat atcagcggga ggctggagca tgccgtattt atcaatcatt 2603641 caccagatcc gcaagcatac gattcgattg gcatcgattt tgaatcggct tcacgccagg 2603701 cgattgatca ccttttcgac ttaggctaca aacggttagg ctacattggc ggacaagaaa 2603761 aagagcatac gctgaaggac ggccaaagca ttcgcagaac gattgaagat aaacgcctga 2603821 ccgctttttt ggagtcagcc gccccccagc ctgagcatgt gctgatcgga gaatacagca 2603881 tgcgtgaggg ctatcgcctg atgaagaaag caatcgatca aggccatctg ccggaagcat 2603941 tctttattgc cagcgattct atggcgatcg gcgcattaaa agcgctgcag gaagccggac 2604001 tgcaagtgcc gcgggatacc gcaatcgtca gctttaacgg cattgaggaa gctgaatttg 2604061 ccagcacgcc tttaacgacg gtgaaggtat acacagagga aatgggccgg acaggcgtaa 2604121 aactgctgct tgaccgtctc aatggccgaa cgcttcctca acatgtcacc ctgcctacaa 2604181 cattaatcgt aagacaaagc tgcggatgta cagcaaagga ggtgacataa gcaaagattc 2604241 atcacgatga taaggaggaa aagatgaaac acacttttgt tttatttctc tctcttattc 2604301 tgcttgttct gcccgggtgt tcagcagaga aaagctcagc agataccgca aaaaagacgt 2604361 taaccattta ttctacaatg tcaaccgaca gtgaaagaga tacgttcaga aaactagcgg 2604421 cagcattcga aaaggaacac agtgacattc atgtcagcct tcatttccca ggcaatgact 2604481 atgaaaatat gatgcgtgtc agaatggcgg ccaatgattt gccagatcta ttcgatacac 2604541 atggctgggg gaaaatcagg tacggagaat atacagcgga tctccgggat atgaaatgga 2604601 ctcaagatct tgatcccaat ttaaacagca tcctcaaaaa taaaagcgga aaggtgtatg 2604661 cctatccaat caatcaggca aaagacggtc tggcgtataa tcgcaatatt ttagaccgtt 2604721 acggcattgc tccgccggaa accatggatg actttatcaa agcactgaga acgattaaag 2604781 aaaagagcaa gggaagcatt gttcccttct ggtttgccgg atatgacaaa agctcattcg 2604841 cccaatatta cgaccaattc gctacacctc ttctcatcac agaccctgcc cataatgaaa 2604901 aaaaacagct catcaacggc acttttcaat ggagtaaatt cacttattta tcagaaatcc 2604961 tcaaacaaat gcagaaagaa aaattgatca atatcgacgc cgtcacggca aaaaaatcac 2605021 agctcattga attaatggcc caaaacaaaa tcgcctttac aatgcaaggc ggcacactcg 2605081 gccaagacgt tgcccagatc aacccgaacg tcaaggtcgg cattatcccg acacctgcca 2605141 tccatcccgg tgatgacccg atatggatcg gcggtgaacg ctacaccctt gcagcatgga 2605201 aagattcgcc tcaattaaaa gaggcaaaag attttatcgc atttatggcc cgcccggcca 2605261 atgccaaaca aatggctgaa gccacatcgc ttccttcagg gctgaccaat gtgaaagctg 2605321 atattttcta cgcaaacgat tatgagtatt atcaagatgt caaagtcgag ccttacttcg 2605381 accggttata cttgccaaac ggaatgtggg atgtcctggg cacggttggg caggagctcg 2605441 cggctgacat tttggcgcct caagacattt cgcagaagct gggaagagaa tataaacgac 2605501 tccgggagca atccgaaaca cagggagctg aaaacaatga gtgagatcgc aagggacgtt 2605561 catgtgaaac aggttaagcc aaaaaagcag tcctcacttt ggtggatgta cattcctgct 2605621 ttgctctccg ttctggtctt tatgatttac ccgtttgtga aaggcacatt gattaccttt 2605681 acaaactgga acggattttc acaagtctac caatgggttg gattcgcgca atatgaaagg 2605741 ctgttttctg atcctgatac ttggcatatc ttaaaaaaca cgctgcatta cgggcttggc 2605801 agcacctttt ttcaaaatgt ggtcgggctt ctgtacgctc tcctcttaaa tcaaagcatt 2605861 aaaacgaaag cggtaacaag aacaattgtg tatttgccgg tgatgatcag cccgctcatt 2605921 atgggctaca tttggtactt tttcttctcc tatgacggag gcgcgctcaa cgatttgctc 2605981 ggggtcttcg gcatcagccc tattaatgcg ctcgccagtc cctcgctcaa tccatggatc 2606041 attgtcatga ttaacaccta tcaatatgtc gggatcgcta tggttgtcta cttagccggt 2606101 ctgcaaagca ttccgaaaga ctactatgaa gcggcgcaaa tggatggcgc gaaacaaggc 2606161 cagcagtttt ttaccatcac gctgccgctg ttaatgccct ccattaccat taatatagtc 2606221 atcaacatta tcggaggctt aaagctgttt gacgtcatca ttgcactcac cgcaggcggc 2606281 cccggaaatg cgtcacaatc catgtccacg tttatgtatg atttgtattt caaacggcag 2606341 gatgccggct atgccgcaac gcaaggcata tttatggcat ttgtcatttt gatcatcagc 2606401 ttttgcgcgc ttgcgtactt taaaagaaag gagacggaaa tgtcatgaga gccgcccgta 2606461 caaaaagcat gcggatcatt acgcttcttg cagccattgt ggcctgtgcg cattttattc 2606521 ctttttatat cctgctgacc acttcattga aagcaaaagg agactacagt tcgaaatgga 2606581 tatttccagc cgacatctcc tttcataatt tttcagaggc gtgggagcgc gcttcgctag 2606641 gaaactcttt tataaacacc atgatcatca caggtttttc tgccttgtta ttaattatat 2606701 tcggctcact tgccgcctac ccgcttgccc ggcgggaaac gaaactgaat aaagccgttt 2606761 ttgccttgct gatttccatt atgatcatcc ctccgttaac gtccatggtt cctttgtacc 2606821 gaatggtcgt ggacgccgga atggtcaata cacacgcaat cgccattttc atcaatacag 2606881 cggcttacat gccgttaacc gtattcttat attcaggctt tatccgatcg accattccaa 2606941 aagagcttgt agaagccgca agaattgacg gtgcaggcat gctgaaaatc ttttttacga 2607001 ttgtgtttcc tctgctgaag ccgatcactg cgaccatctg tatcatttct tgtgtcttta 2607061 tttggaacga ctatcaattt gccattttct ttttacaaga tcaaaaggtt cagacattaa 2607121 cagtagccat ggcaggtttt ttcggagaaa acgcaaacaa ccttcattta gttgccgcag 2607181 cggcacttat ggcaatgctg ccgatggttg ttctgttttt ggcgctgcaa aaatacttta 2607241 ttgccggcct gtcttccgga gcggtaaagg gttaacatta aagggggaag caatatgaaa 2607301 aagattacat ttatcggtgc agggagcacg attttcgcca aaaatgtttt gggagactgc 2607361 ctgttaacag aggcactgaa tggatttgag ttcgctcttt acgacattga tcccaaacgc 2607421 ctgcaggaat cccagctcat gctcgaaaat ctaagagacc gttataaccc aagtgtggcc 2607481 atcaacagct atgatgacag aaaactcgcc ttgcaaaacg caggctatgt catcaatgcg 2607541 attcaggttg gaggatacaa accgagcaca gtcatcgatt tcgagattcc taaacggtat 2607601 gggctgcgcc agacgatcgc cgatacagta ggcatcggcg ggatattcag atctctcaga 2607661 acaatcccgg tcttatttga tatcgcaaaa gatatggagg aaatgtgccc tgacgcatgg 2607721 ttcttaaact atacaaatcc aatggccact cttacaggcg ccatgctccg ctataccaat 2607781 atcaaaacaa tcgggctctg ccacagtgtt caagtgtgca cgaaggattt atttaaagct 2607841 ctcggaatgg agcatgacgg aattgaggaa cgcattgcgg gcattaatca tatggcttgg 2607901 cttttggaag tcaaaaaaga cggcacagat ttatatccag aaatcaaaag gagagcgaaa 2607961 gaaaaacaaa aaacaaagca tcatgatatg gtgcggtttg aattaatgga taagttcggc 2608021 tattatgtca cggaatcgtc cgaacataac gcagagtatc acccgtactt tattaaacgg 2608081 aattaccctg aactgatcag cgagctgcaa atcccgctcg acgaatatcc gagaaggtgc 2608141 gtcaagcaga ttgaaaattg ggagaaaatg cgggatgata tcgtcaataa taaaaacctt 2608201 acgcacgaac gctcaaagga atatggttca agaattatag aagcaatgga aacaaacgaa 2608261 ccattcacct tcggaggaaa cgtcttgaat acagggctga tcaccaacct tccttcaaaa 2608321 gcggttgtgg aagtgacatg cgtcgccgac agaaaaaaaa ttacaccgtg cttcgccgga 2608381 gaactgcctg agcagcttgc agccttaaac cggacgaata ttaatacaca gctgatgaca 2608441 atcgaagcgg ctgtcacacg aaaaaaagaa gcggtttacc aagctgcaat gcttgatccg 2608501 catacaagcg cggagctttc catgaaggac atcatctcca tgtgcgacga tttatttgca 2608561 gcacacggcg attggcttcc ggaatacaaa taaaaactag gggaccgctc tcccctagtt 2608621 ttttggtttt gtttcgcctt cccaggccat catgccgcct tcaacattga ctgttttaaa 2608681 gccttgctca tccaggtact tgcagacgtt catgctgcgc attcctgagc ggcagataaa 2608741 tacgtactct ttgtctttat caagggtttc cattttttca ggaatatccc ccatgcgaat 2608801 atgaacggct tgcgggatca tgccttccgc tacctcttca tcttctctga catcaattaa 2608861 atataattct tcgtccgcct caattttttc tttcaaagcg gctgtgctga tttcttttat 2608921 ttccaaagaa aacactccta ttcacagtga tcatgttcag tatatcaaag tcagccgaac 2608981 gattgctatt ctgagactga tgaaaaaaaa tccccttttg gcaaagggga ttttttctag 2609041 gcttagtttg ccacaatatt gacaagcttc ccaggcaccg cgatgatttt ccgaatcgtt 2609101 ttgccttcaa gctgctcttt gaccttttca tctgcttgag caagctgttc cagctgttct 2609161 ttcgttgcat cggcaggaac ctgtaatttc gcttttactt ttccgttcag ctgaacaacg 2609221 atttcaactt catcatccac aagttttgtt tcatcatata caggccaagc ttcgtaggca 2609281 attgtgccgg aatggccaag cttctcccat agctcttccg ctaagtgtgg cgcgacagga 2609341 gaaagaagct tcacgaagcc ttccatatat tctttcggca gttctgttgc tttataagct 2609401 tcattaataa agaccatcag ctgggaaata cccgtgttga aacgaaggcc ttcataatgg 2609461 tctgtgactt tcatgaccgt ttcatgatag acgcgctcca atgtttcacc cgcgccttca 2609521 acgatttttc cattaagctc accgctgtct tcaataaata ggcgccatac acggtcaagg 2609581 aaacggcgcg caccgtctaa tcctgattca gaccaggcga ttgaagcatc aagaggtccc 2609641 atgaacattt cgtacaatct cagcgtatca gcaccgtgag aggccacgat ttcgtcagga 2609701 ttgacaacgt tccctttaga tttactcatt ttttcgttgt tttcgccgag aatcattcct 2609761 tggttgtaca gcttttggaa cggttctttc gtcggcacta cgccgatatc ataaaggaac 2609821 ttatgccaga agcgggcata cagaaggtga agcacggcat gttctgcacc gccgatatac 2609881 atatcgaccg gaagccattt ttccaatttt tctggtgatg ccagctgatc cggattgtgc 2609941 ggatcaatat agcgcaagaa ataccagcag cttcccgccc attgcggcat tgtattcgtt 2610001 tctcttcttc cttttttccc tgtctcaggg tctgtgactt ccacccactc tttaatgttc 2610061 gcaagcggtg attcgcccgt tccgctcggt ttgatttcat ccgtttttgg caaaatcagc 2610121 ggcagctcct cttccgggac agctgttgac gttccgtctt cccaatgaat gaccggaatc 2610181 ggctcgcccc aataacgctg gcggctgaag agccagtcac gaagacggta cgtcactttc 2610241 ttctcaccgt ttttcgtttc ttccagccaa gcgatcactt tttcaatcgc ttcctgtttg 2610301 tgaaggccgt tcaggaaatc agagttcacg tgctcgccgt cgccagtata ggctgcttcc 2610361 tcaacgttcc cgccttttac gacttccttc accggaaggc cgaatgtttt ggcgaattca 2610421 aaatcacgct catcgtgtcc tggaactgcc atgacagcac ctgttccgta tgatgcaaga 2610481 acataatccg caatccaaat cggcagtttt tctccgttta caggattgat cgcatacgct 2610541 cctgtaaata cgcctgtctt tgttttcgca agatctgtgc gttctaggtc actctttgat 2610601 tgaatttctt tgatataagc ttcaacagct tctttttgct ctgccgttgt gatgttttcc 2610661 accaatgcgt gttccggggc aaggacagtg tatgtagcgc caaacagcgt atctggtctt 2610721 gttgtaaaca ctgtaaagga atcatcatgt ccatctatag caaaatgaac gtgagcgcct 2610781 tccgaacggc cgatccagtt gcgctgcata tctttaatgc tttccggcca atcaagctct 2610841 tccaagtcct caaggagcct gtccgcataa gcggtgattt tcagcatcca ctgcttcatt 2610901 gggcgtctct ctaccggatg gccgccgcgt tcgctcttgc cgtcaatgac ttcttcgttg 2610961 gcaagaacag taccgagcgc agggcaccag tttacaggca cttcgtcaac gtaagcaagg 2611021 cctttttcgt atagctttaa gaaaatccat tgcgtccatt tatagtattc agggtcagtc 2611081 gtattgattt cgcgatccca gtcatatgag aagccaagcg cttgaatttg gcggcggaag 2611141 ttatcaatat tctgcttcgt aaacacagcg gggtcgttcc ctgtgtcaag cgcgtactgt 2611201 tcagctggca ggccgaatgc gtcccagccc attggatgaa ggacatcata gccctgcatg 2611261 cgcttcatgc gggacagaat atccgtagct gtgtatcctt caggatggcc gacgtgcaac 2611321 ccagctccag acggataagg aaacatgtcc agcgcgtaaa atttttgttt ttcattatta 2611381 tcaagagtgg caaatgtttt gttttcaagc caatatgtct gccatttctt ttctatctct 2611441 ttgtgctgaa aactcaaagt aaaaacctcc ttctgattga atacggcgtg tatggttcaa 2611501 gtattgacgg gaaggagagg attatattca gaatattccc aaactaaaaa aaactccctc 2611561 atcccaaaaa gggacgagag actttcgttt tcccgcggta ccaccctcgt tagcgcggca 2611621 tacgccgcac tcacttgata cttttaacgc agttatgcgt cagcggcttt tcaccgctgc 2611681 aactctgagg tgagttcgga aacaaacttg attgactttc accagccgtc aactctctgc 2611741 aacaatatct gtttcttact gctcctcttc attgttctta tcgcaaccgt aatctaactg 2611801 tattttatag aattctgttc ataagtgcaa gcaggtttgt atacaatggg aatgtaccct 2611861 gaacgggcgg agattgagga caattattcg ggtggagttt tggtttgacg tttggactcg 2611921 gccggttcgc cgccgctgtt cagttctctc acaaagtcaa aacttctgag aacagcttca 2611981 ccgccgtagc ctgagataat ggataagatg acaagttgaa ttcctgaatc ggggtcagcg 2612041 gataatacaa gtaaaatgga agccgtcatg ccgataaacc aatcttccaa aaatccaagg 2612101 tagataaacc gcttcgtcat tctgggcttc tccagcctgc ctctcttttt cacatgaccg 2612161 agaatcccca tgattcctcc aattacacaa gcaatgagta cctgatgcag catcttcatc 2612221 atcaccttcc taaagccctt atttcgtaaa gcgacttcag gccatccagc ccccttaaac 2612281 gattccgatg attttcgata tctacatacc ggcaaatctg taaaaagctt gtttcttcca 2612341 ttatatgtga acacatgatc ggtaagcttg atgcattgga ttcatttttc acccagtgac 2612401 attgacctag tcacctattt agcatgtaga aaacctttcc gttcatatgt tcaaattctg 2612461 ttcttatttt tagtgtatac gaggacaagc cctaatgaca aacaacaaac tgcacttgct 2612521 tgaatcagaa catgtgttgt gctacggtta ctgtagaatt catttttaaa aaggggaata 2612581 tcaggctttc gcatagcaag ctgacggcct aagggggatt tatatggcta gttttcaatc 2612641 atttgggata ccaggacagc tggaagtcat caaaaaagca cttgatcacg tgcgagtcgg 2612701 tgtggtaatt acagatcccg cacttgaaga taatcctatt gtctacgtaa atcaaggctt 2612761 tgttcaaatg accggctacg agaccgagga aattttagga aagaactgtc gcttcttaca 2612821 ggggaaacac acagatcctg cagaagtgga caacatcaga accgctttac aaaataaaga 2612881 accggtcacc gttcagatcc aaaactacaa aaaagacgga acgatgttct ggaatgaatt 2612941 aaatattgat ccaatggaaa tagaggataa aacgtatttt gtcggaattc agaatgatat 2613001 caccaagcaa aaagaatatg aaaagcttct cgaggattcc ctcacggaaa ttactgcact 2613061 ttcaactcct attgtcccga ttcgcaatgg catttcggct cttccgctag tcggaaacct 2613121 gacagaggag cgatttaatt ccatcgtttg cacattgacg aatatcttat caacatccaa 2613181 agatgattat ttgatcattg atttatccgg attggcccaa gtgaacgaac aaacggccga 2613241 ccaaattttc aagctgagcc atttgctgaa attgaccgga actgagttaa tcattactgg 2613301 cattaagcct gaattggcta tgaaaatgaa taaactggat gccaattttt cgtcgctgaa 2613361 aacatattca aatgtaaagg atgccgttaa agtgcttccg attatgtaaa aagatcccgc 2613421 tcacccagct ggatctttca gattgttgac aaaatcctaa aatggttttc attttaggat 2613481 tttgtcatct tttcagcgtg attgaaaacc cttgaagtct aggaaggacg agcataggag 2613541 cggagcgaat gttctaattc gtgagcaccg aagcgcaggc ctgacaacga atgcgagggt 2613601 ttgtcgacac gctgaaagat cccgctcatt cggcgggatc ttttattatg aagagattga 2613661 tgcctgctta tttgtttctt tagctgattt tatccgtttg tcatatagaa gcgttgtggc 2613721 aatactgatc agcagcaata ccaacagaga taaaacaaga gccctaatgc cgtaatgatc 2613781 gacaagcact cctccgaaca ggggaccaat cattctgccg cctgtcgccg cactgttgac 2613841 aaagccttga taaaagcctt ctttcccttt aggggcaagc tgattggcaa tagtcggcac 2613901 agcaggccaa acaagcattt ctccgatagt caggatcacc atcgcagcga gaaacatcgg 2613961 aaattgcttt gcagtcagca gcatgctgaa agacacaata aaaatgataa agccgatgac 2614021 catttgcgct tttagcgact cggcccattt tttcaccaca aaactgacga gcggctggcc 2614081 gagcacaatg agaattccgt taaccgtcca cagcacgctg tataaggaaa gagatattcc 2614141 aatgctttgt gtgtacgaag caattgtggt tgaccactga gaataagcca gccatccgag 2614201 tacatagcct ccgcttaaaa tgatcagtgc ggcaaatttt gctttgctgt tcacagcatc 2614261 ataatcaagc acggatgttt gggatgcatc gcccgtttga atatttcgaa atccgaaata 2614321 tacaataaag aaaaagatca gatacaatac ggcatttgcc aaaaatacat atgaaaacga 2614381 gaaagatgcc acgacaccgc caagcgctga accaacggcc acgcccgcgt tttgcgcgac 2614441 atatatcgca ttaaatgcct tccttccccc ttcaggccat accgatcccg ccattgcgta 2614501 gcttgccgga aaaacaacac cggagccaaa gcccacaatc gtcagcagca caatataggc 2614561 tggccaatca tgaaaaaaga caagacccat caggcttgct aacgtaatgg ctatcccaag 2614621 cataatcgat ttaaaaccgc cgattttatc aaacaaaaaa cctccgcata aattgccagc 2614681 cacactggcg ccggaattca gcatcaggac aagtccggct actgttaacg actttcctaa 2614741 atgattatgg atataaatcg tattcagcgg ccataaaaaa gaagcacccg tcacattgat 2614801 aaacattcca atgactaaaa ttttaagagc acgcggcata ctcatccccc tttcttacct 2614861 aaaaaagctc atgaaaaaaa cgaaacctaa aacggctccg tacgaatcca gttatcatag 2614921 cacattcatt ctatctgtct ctctcacatt tttcaactga tgagcgtgaa aaaatctaac 2614981 aaatattgtt tgaaaaatgt aaaataaata gaaaaagggg tcatattatg gaaatggtat 2615041 tagcattctt aggttttctg gcatgtctca ttgcactggg ctatggatta tatcaccttg 2615101 tcagatatgt actgaaaaag gaaaaacgtt tctcaaagag acttttttgg ccgcttttca 2615161 ttggaggcct tgtgctgctc tttaccgggg cagcattggc agaacctgac actgccgcag 2615221 caaatgccga gaaaaaatat tcagcgctaa acgccgaata taaaaacctc acaaaagagc 2615281 acgaagaact tgagaaagaa tataaatctg tcagctctga agcaaagaaa ttaaaagaca 2615341 acaaagaaga tcaagacaag cttgagaagc ttaaaaacga aaatagcgat ctaaaaaaga 2615401 ctcagaaatc attaaaagct gagattaaag agcttcaaga aaatcaaaag cagctcaaag 2615461 aagatgcaaa aacggcaaag gctgaaaatg aaacacttcg acaagataaa acaaagcttg 2615521 aaaatcaatt aaaagagacg gaaagccaaa ccgccagctc tcatgaagac actggaagtt 2615581 cttcaaacaa tacgagtaaa agtgatgaaa ccaaaacagc tgacaaagca gaaggctgta 2615641 atatcaaagg aagcagaaac ggcatctacc acacgccagg cagtacatac tacgaccgga 2615701 caaccgatcc ggctgaaatg ttttgctcag ttgaagaagc tgaagccgcc ggttatcggg 2615761 cgccaaaacg ataaacaaaa agctccagaa tgtctggagc tttttctgtt tcacaacgac 2615821 gatttaatga ccttcttata ataaagaact gacagaaaac caaaaatgga gtagagcgca 2615881 gtatataaca ccatcaccat aatcataggc gcccatacct ctgatccgaa taagaaccag 2615941 ccggattgga cggcaaagta actgtggaag aggccgacaa cgagcggaat gccgaagttg 2616001 tacatttgtt tgatgcgtat cccctttatc aggtcgccct gcgtaaagcc gagttttctt 2616061 aaaattgtat agctcggttt ttcatcttca ctttcaccca tttgtttaaa ataaaggata 2616121 caacctgatg taatcaggaa cgttaaccct aagaagccga cgatgaacat caccatacca 2616181 aacagtgatt tttgcgcagc gcttgtatct agtcttgata aatgctcgtt tttcttgttc 2616241 acctgttgaa aaagctcatt tgctttttcc atttgatcgt catgtttcac attgacgccg 2616301 ataaatgtag attgcgccag ctgaatgcgg gggtctttat ccttgtccag ctgtttaaac 2616361 aggctgtcat ccacaatgac agcgggcatg cccccgcttg taaacgtgta ggacacaaga 2616421 aactcttctc ttaatccttt atattttaat ggctgcgtct cgtgcttgct ttttacttta 2616481 ataacaccag agtccttgaa aaccattatt ttttgcagca agtcggtgta tcctgagaaa 2616541 acggcttctc cagccgccac atcgactcct tttacatctt tgtcgctaac aacagcaagc 2616601 tgcatattgc cgggatcgcc ctgcatctct ttcggagttc catccataat atttgcaatg 2616661 tcaacatttg cttgcaggac aggtgttgcc ttttttacaa acgagatgtt gctttccctc 2616721 aatttgtttt caaataactt ggcatctttc tcattcatga atgaaaaatc agccgctaca 2616781 ttttgttcag cggtcttttc cgacgagtaa tacgagatgt aagcaagaga taacagcccg 2616841 atggcgagcg ctgaaacggt tgtaataatc gtcagcagca gcgcattcga tttcattctg 2616901 aacatgatcg aagacagtga cagaacctca gaaatattta agtagccgcc cttgcttttt 2616961 cgaatgatat tcgagataaa cgtaactgat cctttataaa acaaaaacgt cccgataatg 2617021 acgctcccca gaatgaagct catcgcaaca aacagttcat taatggtctt aaattttccg 2617081 ccaaacagct cagaagacac atagtatcct gtcaaaatca acacgatgcc taaagcgccg 2617141 atcagcattt ggaaaaatga tattttcttc actttgtctt cagtggagga cgttacttta 2617201 aacaaagata aaatactctg ttttttgata aacgtataat tcatgatcat gatcaaaagg 2617261 taaatgccgc agaacacaat gaccgtttgg accaaggcct gctcagaaaa atgcagtttc 2617321 gcatccgctt tgacatcgac aattttgaac agaatcatca agacaagctt cgatatcgaa 2617381 aacccggccg ctaccccgat cgctaatgaa ccgaaataca gcatgacatt ttctgcactt 2617441 aagatgcgaa aaattttatg cttcgtcatt ccaattaatt gaaacagccc gatttcttta 2617501 ctccgtctct taataaaaat cgtattggca tataaaatga agatcgccac tacagccaca 2617561 agcaaaatcg aagcggtttt aatagccgcg gctcccttga ttgaagcctt cacttcgtta 2617621 attgctggat catactgcag cgtgacaaag gcgaaataaa gcgccacgct aaagatgagc 2617681 gcaaacacat acaaatagta attccggaga ttctttttca aatttcgcag gatgagctga 2617741 ttaatgttca tgctgcaccc cgcctaacac gccttgcgtt ttcataatat cctggaaaaa 2617801 cgtttgcctg tcctggcccc ctttattcag ctgtgtatac atttgcccgt ccttaataaa 2617861 aatgactctg ccgcagtagc tggcagcgac gggatcatgg gtaaccataa taatcgtcgc 2617921 gttgcgtttt tgattgagct ggctcagctt atttaataga tcggaggccg atttcgaatc 2617981 gagcgcgccg gtcggttcat cagcgaaaat aatgctcggg tcatgaataa acgctcttcc 2618041 agcggatgtt ctctgcttct ggccgccgga aatttcattc gggtatttat cccgcaattc 2618101 atatattccc agttccttgg caacttcctc aaacttgcga ttggcttcct tttttgatag 2618161 tttcgtgatc gataaaggca gaaggatatt ctctttcact gtcaatgtgt ctaacaaatt 2618221 gtaatcctga aagataaagc ctaaatgctg ttttctaaat tcagccagct gcttttcctt 2618281 catagccgtc atgtcatttc cattaatatg aatggttccg tgactgacct gatcgattga 2618341 ggacagaacg ttgagcaaag tggtttttcc cgacccggaa gcacccataa tactgacgaa 2618401 ttcgcccttt tcaatgtgaa tatcgatgcc cttcagcact tcctgtttat tcagcttgtt 2618461 tccataactt tttcgaattt tattcgcttc taaaatcacc atttacgcag tctcctttat 2618521 attggataat ctcattataa aaaggaatgc cgggcttttc cttcgatacg gcgaacaaaa 2618581 aagaaaagca tgtgacattt tcgtcacacg cttatgacat gttcaaattg attccgtatt 2618641 ggaaaggtta atgtaaaaac tgttcccgca ccaaactccg actcaacatc aatatggatc 2618701 aataacggcg ccgctgcttt ttttgccaag tacagcccca tgccagttga cgcttgatca 2618761 tggtgatccg ttgtggatgt aaacccttta tcaaaaatac gcggtacatc ttttggatca 2618821 atgcccctgc cacaatcttt cacttggagc tgcgtctgtt cccctttttg aaagcttttg 2618881 atctcgattt cagaggcttc gctgtatttc accgcgtttg tcagcagctg cctgatgata 2618941 aacgccagcc attttgcatc gctcagcact tctttggcct cgagctgtat gtcaaaaccg 2619001 atcccttttt ggatacacca cgattgtaaa tctttgattt ctttaaagat caaaggctga 2619061 agctgaatga attctactga caggtcgttt tcaataaatg aaatgcgttt ttgatgaagc 2619121 tgctgatcaa gaagcaggtg aatacgcagc cattcatatg acagctggga tttcagtgct 2619181 ttttcttcca ttctatcaat gattaaatgc atcgctgtta atggagtttt gacctcatgg 2619241 atccatgcca tcagctcatc tttttcattt tccaatgcta agcgatgccg tgctgcggtc 2619301 tgcttcaagt gttctgtttg cccggcaatg cttctttcaa ccattgcttc aaacggcgtt 2619361 tccggttcat ttatggctgt cacatcgaga ttgttctccc atgttttcaa gcttttataa 2619421 aacgctgttt ctttccgata gcggaaccaa aggaatatga taaaaaacaa gatgcacaaa 2619481 tacaccatat aaagtacatt cccaaatgat atggaaggat cgacaaaagc aatgaacagc 2619541 atcaaagcct gctgaaacaa aaacgcggca atccagctcc gcctttcgat aaggaatgct 2619601 ttaatcatag aacttgtcct cttccttcgc gatgtagccc tggcccacct ttgtctcgat 2619661 atatgcacca agctgcaggg cgtccagttt ttttcgcagg cgattgacat tgacggtcag 2619721 cgtattatca ctaacaaaac gctcatcgtt ccacaagctt ctgatcagct cttcccggct 2619781 gacgatcttg tttttttgct ctattaattg ttttagaatg aacatttcat ttttggtcag 2619841 ttcaacagat cctttgtcat tgctgacgag gttctgctcc gcgtctacag cagcgccgca 2619901 ccacgtttta atcgtactcg gctccgtatt ataatggtgc acacgccgga acatcgcttg 2619961 gattttcgcg atcagcacat caaaatgaaa tggcttttga ataaagtcat ctgccccgag 2620021 ctgcatggac atcaccatat cagcaggatg atcccgggag gataaaaaga gaatcggaac 2620081 atttgaccgg gagcggatca gacggcacca atgaaagccg tcaaatttag gcagctgcac 2620141 atcaataatg acacaatcag gattaaccgc cgcaaattcc tgcagcacct gactgaaatc 2620201 ctgaatgccg tatacatcat aggaccatcc cgttaaacga tccttgattt catgaaacag 2620261 cgattcatca tcttcaatca gcaaaagttt aaacaatcga ctcaccgcac tttttccttt 2620321 tttatcaagt gtatagcaaa acgccagcat gcgctataga aaaagccggc tgtctcagcc 2620381 ggctcgttcg cattataatt ctcttctcaa cgctgtcagc acgttggttt tggtagcttt 2620441 tctcgccggg ttcattccgg aaatgactgc gacccctccg caaatcacaa cggcaatgat 2620501 cacaaggctc gccgggatgt aggagaatgt gtaattcaaa tcgcccgcat cgccaccgct 2620561 tgtggccgca agaatcatcg gaacggccag gttgacaagg tagctcacgc cgtaagaaat 2620621 gataatccca atcacacagc ctaaaattcc gatatacgcg ctttccatca agaacattcg 2620681 gcgaatgatt gacgggctcg ccccaatcgc tttcataatg ccgatctctt gcgttctctc 2620741 tgtcaccgcc atcgtcatcg tgttaaaaat gccgatcgct gaaatgataa ctgcgataca 2620801 tccgacaaag atcagtccga ttttgaagac catgaagaag gtattggctc cctcaagttc 2620861 agtagtcact gatgtgacat agtacccgtc atctgttaga tcatttgtca gctgttccac 2620921 attctcaaac ttatcagcaa aaacaccaat gttcgtttca acatttccgc ctttgaaatc 2620981 taagaattcc gaaaaatctt ttttgaattg atcactgata aaaatatttg agtcctccat 2621041 ccagtcttga gatggttttt ttgtaatacc gacaatttta aagtcatatg tttttgtttt 2621101 tgtaacatcc cctgttttag aatctgtctt cgatacactt agttcaattg ttttatttag 2621161 aatatctttc gtatagccct ttggttcttt tatatcttct ggatttcctt ttgcttcctc 2621221 gatttttttg ttatattctt ccgattcttt tttcgttaat aatctctttg cgaagtcgta 2621281 tcctactacg atttcatttt ccgactttgc gactcttccc ttttccaatt ccatattggc 2621341 ctttaattca tcattcatat tagtaaaaat gagatttgag ctttcatttg tacgattgcc 2621401 taaagtagct ttgtttggtt catacacttg cgttctttct acaactgacc ttacgtgatc 2621461 atacttctct aaatcagctt ttttaatcgg cttgtctcct tccttgccca ttacgctgac 2621521 tttcgttaca atctgctggc tcattgtcat atctgtaatc gtcttttgaa tcccaaatcc 2621581 aacggacgac aacacaacca aaaacgcaca cgccattgtt gtcgccagaa tcgtcataaa 2621641 gacgcgaagc ctgtttttct tcatatttct tctgataaaa tgaacctgat ccttaaacct 2621701 caacggtaat tcctcctttt agcacaccat catgaagctg aaattttgaa tgtccgatag 2621761 aagcgacttc atcatcgtga gtaatgatca caaatgtaat gccacgctca cgattcagct 2621821 gctggatcaa ttccagcact tcatgttccg tttctgaatc aaggcttccc gtcggctcat 2621881 ccgctaagat aatcgaagga tttaaaatca atgctcgagc aatactgaca cgctgctgct 2621941 ggccgcctga cagttcattc ggataatgag cggcgtggtt ttccagaccg acgcgtttca 2622001 gcatgtcctg caccttttgc ttccgctcag atggcttgat tccttttaac gccagcggca 2622061 tttccacatt ctcatacgtc gttaaacccg ggatgagctg aaagctctga aaaataaacc 2622121 cgaaatggtc aagccgaaat tgcgcccatt ccttttcatt aaaccccgta acatcagtgc 2622181 cattaatgac aatccgccct tttgtcggcg atatgtagcc ggaaattaaa ttcaaaagcg 2622241 ttgatttccc tgagccgctt cgtccgacaa tgcaggcgat ttcccctttc gccacgctca 2622301 atgaaacatc cttcaatact ggaacttcat tctcacggcc cttttttccg atcgtgaaag 2622361 aatggtcgat atgctgaaca tcaatcatat gttctctctc ccttacaaaa gtttcatttt 2622421 tttataaatc gcaaaataac taatcaagaa accgattacc gcacctgtac ccatgccaat 2622481 gagataaccg gcaaagctct cgcttgcagt aaatccaaaa tagccgaagc ccatgattcc 2622541 tatgataata acgatgatct gcaccgggcg gttaagcggc ttccataaga agaaatatcc 2622601 gtttctttca ttagacattt taacaaagct aatatagccg atgatgtaaa aaatgatagt 2622661 catgatagcc ggaatgacta aataatatgg tgaattctca gcccatttcg agtctacata 2622721 aattatcgga atgaaatact gcacccattt aggtactgga ccatggataa aatctattga 2622781 tccgccaaaa aggatctcga ggttgatcac aggcaggctg atgagtaaaa acggcgaaat 2622841 ggccacggta aatgagacta gaagctgtgc gaaactattg cctgtcaaag ctcctccggc 2622901 cataaccaaa gaataagcca gcatgctaac aataatcatt cccaagctgt aattgtgaaa 2622961 ataaacggcc tgatctggct tcaaaagcat gatcagcaaa acagacaaaa cataacctat 2623021 gagctgcggc accacaatca ccattccgcc ggtaaggaac ttcgcatgaa atatctgccc 2623081 tcgtgtatat ggaaggctta atgtaaaatc aaagaagctc ttgctacgtt caatcccaag 2623141 ctggctgacc gccaaaacga ctccccaaat ccaaaacaat gagataaatg agctatttaa 2623201 ataatcaacg ctgaatacgc aggggccgac ccaattttct tttccagtga cacagccttg 2623261 atagatgaga tacatattta aaattgataa tggattacct aatataaaaa ccaaaatggt 2623321 gataactaag gcgactttat tctgccgcca ctctttgtaa agcagtccgg aatccggcaa 2623381 ctcacttccc tccaaaccta aggcatttct tacacttttg ttttcttata aatagagaag 2623441 tagctcacaa agaatccagc cactgctcca atgatcatac ccaaaatata accaataatg 2623501 gaatgtccgg tatagtatcc aaataaacca aatccaagga tgccgaaagc cataaccaga 2623561 atttgcaccg ggcgatctaa tctgttccat aagaaaaagt gtccgttccg ttcacttgga 2623621 agcttcttga agcttataaa gccaatcaag taaaatagca tgctcattac ggctggaatc 2623681 aataaaagat atttactgtt aatcagccat tcatttacaa cgtaactaat cggtactagg 2623741 ttcgataaat tgcttgccag agagaaataa ctctcagggg aagggaatat ttcccatata 2623801 ttcgcaccaa aaacaacttc taggtttcca accggcaatg caataattaa atacggcaat 2623861 atagctgctg aaaacgccgt taacagttgg gcaaaagcat ttccagttaa cgctccggcg 2623921 gccatcacca gtgaaaaagc cataaaactt atcacgatta ctccaatgct gctgtgctca 2623981 aaaaagtaga cgtgttcagg gttatagaca agaatcagca gccatgcaag taaaaagcca 2624041 atcaattgtg acagcacaat cacaaaaccg cctaaccaaa attttgtctg aaaaatttgg 2624101 cttctgttat acgggaggct taatataaaa tccatcgtgc ctttcgaacg ctccattccg 2624161 aggaagcaga ccgccaaaat gacacccggc acccagttga tatctatcag attgcttatg 2624221 gaataattca caataaaatc acaatattgc gggtcttggc gatcaagaca cccttgataa 2624281 gacaaatacg tattaacgat agaaagcgga tttgccaata ctaaaaacgc gatacttaac 2624341 aaaatcacca cttgattctg cttccactct cgatagagga gacctcggtc taccatctcc 2624401 gcttccctcc aaacttcgca atgaacactt cttccaggtt gacaggaagc tcattccaca 2624461 cttttggctt cagctctctc aaaaagctct ttttctcctc atcgcttttc ggaatcagca 2624521 ctgtgtaaaa cacgccggcc tgatcgagca tcggaatgtt ttgctctctg atggccaaat 2624581 tgacatctgt atcgaaggcc atttgaattt taatgtattc ttcttttaac tcatcaagat 2624641 ccatgacgtt ggtcaggctg ttatcttcaa gaaaaccaat tcggttgcac atccgctcta 2624701 tgtcttcaag ccggtgggac gtaatcagga tgctcgtatc acgctctgcc acttcatcga 2624761 ccatcagctg cagcacatca tgccttgtca ccgcatcaat accatccgtc ggctcatcaa 2624821 ggaggatcag cgccggtctc gccgcaaacg acagaacgag cgatagctgc ttttttaagc 2624881 ctgtcgacag ctcacggtat tttttcgttt ccggaatttc gtatctgttc atcagctcat 2624941 tcgcgtacgt gacatcaaat ttcggatata ttcttctcaa aatatcgact aactgcttgt 2625001 atgtatactt atcgtaaaac ggattttgaa caggcatgta gatgatattt tgtttgactt 2625061 tcgggtgctt tttgatttct acgccgtcaa ataaaatcgt tccgctgtca gcgaaaatga 2625121 tttgctggat taagcgaagc atcgtcgttt tgcccgatcc attgcgtcca agcaatccaa 2625181 agatttctcc tttttcgatt gttaatgaaa catcttttaa tacttgattg ccgtcaatcg 2625241 cttttgacag ctgccgcagt tcaatcattt tttttgcctc ccttcacatc agcgctgatt 2625301 tcctttatcc attcgtgcag tttttccagc tcaacccctg catagtgtgc atcgatgatg 2625361 agctgtttga gttgctcttt aatcatcgtc atcttccctt caaccagtgt cgtttttgca 2625421 ttctccgata tataggtccc tctgccccgc agcgtttcaa taatcccctc tcgctcaagt 2625481 tctttatacg ctttgctgac agtgttcgga ttcgcaataa tgatcgttgc caattctctg 2625541 acagaaggaa gcttatcacc aggcttcatg atccctttca aacaaagctc tttcatttgc 2625601 tgaataattt gttcgtaaat gggtgttgag cttcttggat cgatttgaat catttacttc 2625661 cctactttct atacgatctg aaccttttat agataaaaat gatcaattat acttttttgc 2625721 cattcaaaac cgatcatcac aagaacaaga aaaaaagaac aagcgatcac agatgccgca 2625781 atcagcattg gcacgttacg tttgtttcgt tttttatgtt tcataactgc ctcccttaat 2625841 gtcaatatat aaatgatttt atattagtgt ctatagtgta ttacttcaat tagtacactt 2625901 aatacaataa atactttgac tcacaaagtc aatccttttt ttacaaaaaa acggaccctt 2625961 ttaaaagggt ccgttttcct acacatcaag agggtgctgc aggatcatat tattttgcaa 2626021 agattgaagc tgaagtctca ttctgtacag ctgttctctc tgctgatcat ttgacgacag 2626081 ccatagttta ttcaaggcat ttaccgcatc ttctagctgc atttgtgcat cactatattc 2626141 ttgatcgtta taatgctctt gtttagaagc gattttcagc tgttcttcag cataatcata 2626201 ggcctgcata cattgctgga gatgttcatc tactgattgt cttgttgcca cagtaacccc 2626261 tcctcttggt aatggaaatc atccatcatt catattgtag cctcatctga ctttattcaa 2626321 taaagtaatt tatggtcgat attcatttgt tctcttgtga aatgcgtgct acaattttag 2626381 gatgcaatcg tacgcaagga ggcacatgaa ttgtgatgca gaacaatcct tttccttatt 2626441 caaatacgga aaaacgctat catacattga attatcatct cagagaacat ttcggccata 2626501 aggtgtttaa agtagcgctt gacggcggtt ttgactgtcc aaatcgggat ggcaccgtag 2626561 cccacggagg ctgtacgttt tgcagcgcag caggctccgg agattttgct ggaaaccgga 2626621 ccgatgattt aattacgcaa ttccatgaca tcaaaaaccg catgcacgaa aaatggaagg 2626681 acggcaagta catcgcttat tttcaggctt tcacaaacac tcacgccccg gttgaggtgc 2626741 ttcgtgagaa attcgaatcc gtcctcgcct tagatgatgt ggtcggcatt tcgatcgcca 2626801 cacgcccgga ctgtctgcct gatgatgtcg ttgattactt ggcagagctg aatgaacgta 2626861 cgtatttgtg ggtggagctt gggcttcaaa cagttcatga acggactgca cttttgatca 2626921 accgcgcaca tgattttaac tgctatgtgg aaggcgtcaa taaattaaga aaacacggca 2626981 tacgtgtctg ctcgcatatt atcaacgggc tgcctttgga agaccgggac atgatgatgg 2627041 aaacggcaaa ggccgtcgca gatttggatg tccagggcat taaaatccat ctgcttcacc 2627101 tactgaaagg cacgccgatg gtcaaacaat atgaaaaggg caagctggaa tttctttctc 2627161 aagatgatta tgtgcagctc gtctgcgatc agcttgagat cattccgcct gaaatgatcg 2627221 tccaccgcat tacaggtgac ggaccgattg agttgatgat cgggccaatg tggagcgtca 2627281 acaaatggga agtgcttggc gccattaata aagagctaga aaatcgaggc agctatcaag 2627341 gaaagttctt tcaacggctt gaggaggaat cagcgctatg attttgaaga aaattcttcc 2627401 ttacagcaaa gaactgctga aaatggccgc gggagaggga gatattgtcg tagatgcgac 2627461 aatgggcaac ggacatgata cacagttttt agcggagctt gtcggtgaaa acggccatgt 2627521 atacgcattc gacatccaag aatcagccgt ggccaataca aaggaacggc tcggtgacat 2627581 gtatcaagcg cgaacaacgt tatttcacaa aagccatgat aaaatcgctg aatccctccc 2627641 gcctgaaaca catggcaaag tggcggccgc ggtatttaac ctcggctatt tgccgggcgg 2627701 ggacaaatca attacgacaa acggcagttc tacgatcaaa gccattgaac agcttctcag 2627761 catcatgaaa gacgaaggtc tgattgttct cgtcgtctat catggccacc cggaaggcaa 2627821 agctgaaaaa aacgacgtgc tcgagttttg ccgggacttg gaccagcaaa cagcccgtgt 2627881 attaacatac gggtttatca atcagcaaaa tgacccgcca tttattgtcg ccatcgaaaa 2627941 aaaagctcag atcagcaaat gatttgagct tttttctttg aatttttcat ccaggacatt 2628001 ttttgaaatt tccggtaggc tctgccgttg atataaaaga aaagggaggt ttttccgctg 2628061 gctttgatca gcttctttgc gagccggacc tgcttcgtct tactttacca tttttcaaat 2628121 tatatttgaa agcaataacc atcgttaacc cggacgtcat acagttcggg tttcgatttt 2628181 tccataaaac gttcacatat agcatgaaac gtatgacttt tatcttatca caaaactata 2628241 aacagcctct gcaaaaacac atacctattc tttcctgttc tctattttct atgagcacac 2628301 acaaaaagag cccactggga gctctttttg tcagctgata tttcgttcgc tggcagcagc 2628361 cgcatttttt ttatgaaacc cttttccata gtacacagcc agcaagatga gaaaccatat 2628421 cggcccgata atcacggcta ctcttgtatc agggctgtaa gccataagaa tgacgacgaa 2628481 tgctagaaat gccaatgaca cataagacgt aaacggaaat aaaggcattt tgtactttaa 2628541 ttgtttcttt tcttccggct tcaaactttt cctgtatttt atttgagaaa gcaaaatgat 2628601 tgcccacgtc caaatcgctc cgaacgtcgc aatacttgta acccaagtaa ataccttcgc 2628661 agggacaaca tagtttaaca gcactccgac taataaagcg cccgctgaag ccagaacagc 2628721 tttacccggg atgccgcctt tcgtcagctg accatatgct tgtggcgcct ctttctgttc 2628781 cgccaagtta aacagcatcc gccctgtgct gaaaatacca ctgttgcatg aagacagcgc 2628841 ggctgtcaac acgacaaagt taatgatacc tgcggccgat ggaatgccca ctttttgaaa 2628901 tgtgagaaca aatggacttc cttgagagcc aatttcctgc cacggataaa tagacataat 2628961 gacaaataaa gcgcctacat aaaaaatcaa aatccgccaa aatactgtat cgattgcttt 2629021 ggctaacgat ttttgcgggt tttttacttc gccagccgtc accccgatca tttcaatccc 2629081 taaataggcg aacatgacca tttgaagaga caataaaacc ccttttaatc catgagggaa 2629141 aaatcctccg ttgttccaca aattgctgat tccggttgca atgcccccat tgccgactcc 2629201 tgcaataatc atcaataaac cgacagcaat catggataag attgcaacaa ttttaatcaa 2629261 tgcgaaccaa aattccagct cgccgtaagc tttgacagcc aggaaattaa cacccgtcat 2629321 aatgaccagt gccgataacg cccaaatcca gtttggcacg tccggaaacc agaaccccat 2629381 atagatgccg acagcagtga tttcggccat acaggtgaca acccataaaa accagtagtt 2629441 ccaacctgtt aaatagcctg caagcggtcc caaataatca cgcgcatacc tgctgaagga 2629501 gcctgcgacc ggtttttgaa tggccatttc cccaagcgct ctcataataa aaaacatgac 2629561 caggccgctt gcggcatacg ctaccaaaat accaggccct gctaattgaa tagctgatgc 2629621 ggagccgagg aacaacccta ctcctatagc agctcctaaa gacattaaag aaatatgcct 2629681 ttcttcgagt ccgcggtgca gctcttgttt ttgtttttgc atgcttcttc tcccctagaa 2629741 aaaaatatca ttatatcatt tttctgaata ttccgtacgg attgggtaaa tcaatgatga 2629801 tggagaaata aaaggataac aacaaggctt tcgactactc gaaagccttg ttgtctgtta 2629861 cacaaagatg acttctttag gctgatggct cagctcttca ggcatatacc gtttttcaat 2629921 attgatgctg tgccagatca taaagattag cacagtccaa attttacggc tgttatcagc 2629981 cttgtccgca caatggtctt caagaagctg aaggacataa tccttatgga tataagcatc 2630041 cgtttggctt tcttgaataa tattccgcac ccattcgttc atttcgtttt tcagccaatg 2630101 acggatcggt acagggaaac caagcttttt gcggtttaat acgtgctcag gcacaattcc 2630161 ttcagcggct ttgcgaagaa gatacttcgt cgtgccgttc ttcgttttca gctcatcagg 2630221 aatttttgaa gcgacgtcga atacgacttt atccaagaac ggcacacgca gttccaaaga 2630281 attcgccatc gtcattttat ccgcctttaa caaaatgtcg ccgcgcatcc aagtgtggat 2630341 atcgacatac tgcattttgt tgatatcgct gtacgagctg ctttctgtaa agtaagtctt 2630401 cgtcacatcg cgatatgaaa ggttcggatt ataatgcttc aacagctgct ttttgacaga 2630461 ctcttcaaag attttcgcgt taccgatata acgatcctga agcggagtgc agccgcgctc 2630521 aagcaggctc ttccctctca taccttcagg cataacggca gcaacgtgca gaagcatctt 2630581 tttcaagccg gacggaatcc gttcaaacgg tttaagcgaa agcggttcac ggtaaatgtt 2630641 atatccgccg aagagctcat ccgctccttc acctgataaa gcaaccgtaa catgtttttt 2630701 tgcttctttt gcaacaaagt acaacggaat cgctgccgga tcagcaagcg ggtcatcaaa 2630761 atgccatacg atcttcggaa gctcattcat gtattcctca ggcgaaatga ctttgctgat 2630821 attttcaatg cccagcgccg ctgccgtttc tttcgctaca tcaacctcac tgaagccctg 2630881 ctgttcaaag ccgacagaga atgtttttaa gcttggatga aattccttcg caacagacac 2630941 aataaaggaa gaatcaatcc cgccagacag gaacgaaccg acaggaacgt cacttctcat 2631001 atgaacgttt acagagtcat agatcgcgtc tcggacttct ttcacaagct tgtcttcttc 2631061 agtctgaacc ggcttgaagt tcgctttgaa atacgttttg aatgtgatat cgccgtccgg 2631121 gcggattgtg aattgtgaac ccggctctac ttttttcaca tgggcatcaa gcgtgcttgg 2631181 ttcaggaaca aattggaaag acatgtactg ctgcaatgcc tctttatcta tttcaatatc 2631241 attctgagca accattaaac tttttctctc tgaggcaaaa taaacctgat cattgatcgt 2631301 tgtgtagtac aacggtttaa tgccgaatgg atctcttgcc ccataaagca catgatcgtt 2631361 tttattccaa atcagaaagg caaacatacc gcgcagtttg gacgccgctt cttctttata 2631421 gtgacggtaa gtcgcaagaa gaacctctgt gtccgaatcc gtgttgaatg tgtacccctt 2631481 tgcttcaagt tcttctctca gttcgatata gttatagatt tctccgttaa agataatcca 2631541 atatgtttca tcttcatatg ataaaggctg tccaccattt tctacatcaa taatgctgag 2631601 ccgtctgaat ccgaagccga cgtgctcatc atggaaatat ccatcactgt caggaccgcg 2631661 gtgaacgatc atttggttca tttgtttgat tagttcttct tgatcagcgg tttgagctaa 2631721 cggatgcttg ttaaaaaccc cgacaaatcc acacatagta ttgcctccat aattaaaatt 2631781 gtcatcattg aacccctatt tatagacgct gtgaatagta tttggtttca cagttatgta 2631841 aaaaaataaa catgaataca acgataaaaa agggaaagcc gcttaaccag taagcggcta 2631901 taaaattatt ctcctaacgc ttctttacgc agctgctccg ctttgtctgt gcgctcccat 2631961 ggaaggtcaa catcgtgacg tccaaagtgg ccgtacgcag cagtttgttt atagatcgga 2632021 cggcgcaaat caagcatttt gataatgccg gcaggtcgta aatcaaagtt attgcgaaca 2632081 acttcaatca gtttttcctc agaagctttt cctgaaccga atgtgttgat tgagattgac 2632141 acaggctgtg caacaccgat cgcgtaagca agctgtactt cgcaagaatc agcaagctca 2632201 gccgcaacga tgtttttcgc aacgtatctt gccgcataag ctgcagaacg gtctaccttc 2632261 gtcgcgtcct tacctgagaa cgcgcctccg ccgtggcgtg catagccgcc gtacgtatca 2632321 acgatgattt tgcgtcctgt aagtcccgca tccccttgag ggcctccgat tacgaaacgt 2632381 cctgtagggt tgatgaaata ttttgtttct tcatcaatca gctcttcagg aacaaccgga 2632441 ttgattacat gttctttaat gttgcgctga atttgctcaa gtgtaatttc agggtgatgc 2632501 tgagttgaaa taacaatcgc gtcaatgcgg actggtttgt tattttcatc gtactcaacc 2632561 gttacctgtg ttttgccgtc agggcgaagg tacggaagaa tatcttcttt acggacttca 2632621 cttaggcggc gggctaattt atgggcaagt gaaattggaa gaggcataag ctctttcgtt 2632681 tcgttgcacg cataaccgaa cattaatcct tggtcacccg caccaatcgc ttcaatttct 2632741 tcgtcgctca ttgtgccttc acgggcttca agcgcttggt ctacgcccat cgcgatatca 2632801 gcagactgct catcaattga tgttaaaacc gcacaagttt ccgcatcaaa tccgtatttt 2632861 gcacgtgtgt atccgatttc tttaatggtt tggcgaaccg ttttcggaat gtcaacatac 2632921 gtagaagttg tgatctctcc gcttacaaga accaaacctg ttgtcacaga tgtttcacaa 2632981 gcaacacgcg cgttagggtc tttctttaaa atttcatcta aaatgctgtc agaaatctgg 2633041 tcacagattt tatccggatg cccctccgta acagattctg atgtaaataa acgacgattt 2633101 ttactcatga tttgcttcct cctgcacaag gcctcccgaa agaccttgta tatatgatac 2633161 ggaactcgct ccctcttata caatgtacag ttatattaga gaatgttaat tggcatattt 2633221 atgaaataaa aaaacctttt ccatcgagga aagggtttgg tctttgtgcc tttcactctt 2633281 atcgctcaag gaatcataca accttgcaac aggttagcac cttggttgtc tcactcagtt 2633341 gaacataata aataacagag aaaccggttg ctgggcttca tagggcctgt ccctccgcca 2633401 gctcgggata agagtatccg ctcaatgaaa tatcttatcg taaaagggtt tgcaatgtca 2633461 atatgattca gaagaaatag gcacctatat tgagggaaaa caatggaaat gcacacacaa 2633521 aaaacaataa atagtataga ctatttgaaa atatatgtta tactaattca caattagcaa 2633581 aacacaaaaa acgataaagg aaggtttcat atgaactcag ttgatttgac cgctgattta 2633641 caagccttat taacatgtcc aaatgtgcgt cataatttat cagcagcaca gctaacagaa 2633701 aaagtcctct cccgaaacga aggcatttta acatccacag gtgctgttcg cgcgacaaca 2633761 ggcgcttaca caggacgctc acctaaagat aaattcatcg tggaggaaga aagcacgaaa 2633821 aataagatcg attggggccc ggtgaatcag ccgatttcag aagaagcgtt tgagcggctg 2633881 tacacgaaag ttgtcagcta tttaaaggag cgagatgaac tgtttgtttt cgaaggattt 2633941 gccggagcag acgagaaata caggctgccg atcactgtcg taaatgagtt cgcatggcac 2634001 aatttatttg cgcggcagct gtttatccgt ccggaaggaa atgataagaa aacagttgag 2634061 cagccgttca ccattctttc tgctccgcat ttcaaagcgg atccaaaaac agacggcact 2634121 cattccgaaa cgtttattat tgtctctttc gaaaagcgga caattttaat cggcggaact 2634181 gagtatgccg gtgaaatgaa gaagtccatt ttctccatta tgaatttcct gctgcctgaa 2634241 agagatattt tatctatgca ctgctccgcc aatgtcggtg aaaaaggcga tgtcgccctt 2634301 ttcttcggac tgtcaggaac aggaaagacc accctgtcgg cagatgctga ccgcaagctg 2634361 atcggtgacg atgaacatgg ctggtctgat acaggcgtct ttaatattga aggcggatgc 2634421 tacgctaagt gtattcattt aagcgaggaa aaggagccgc aaatctttaa cgcgatccgc 2634481 ttcgggtctg ttctcgaaaa tgtcgttgtg gatgaagata cacgcgaagc caattatgat 2634541 gattccttct atactgaaaa cacgcgggca gcttacccga ttcatatgat taataacatc 2634601 gtgactccaa gcatggccgg ccatccgtca gccattgtat ttttgacggc tgatgccttc 2634661 ggagtcctgc cgccgatcag caaactaacg aaggagcagg cgatgtacca ttttttgagc 2634721 ggttacacga gtaagcttgc cggaaccgaa cgtggtgtca cgtctcctga aacgacgttt 2634781 tctacatgct tcggctcacc gttcctgccg cttcctgctc acgtctatgc tgaaatgctc 2634841 ggcaaaaaga tcgatgaaca cggcgcagac gttttcttag tcaataccgg atggaccggg 2634901 ggcggctacg gcacaggcga acgaatgaag ctttcttaca ctagagcaat ggtcaaagca 2634961 gcgattgaag gcaaattaga ggatgctgaa atgataactg acgatatttt cggcctgcac 2635021 attccggccc atgttcctgg cgttcctgat catatccttc agcctgaaaa cacgtggacc 2635081 aacaaggaag aatacaaaga aaaagcagtc taccttgcaa atgaattcaa agagaacttt 2635141 aaaaagttcg cacataccga tgccatcgcc caggcaggcg gccctctcgt ataaaaaaca 2635201 aaagccaaga gcaattatgc tcttggcttg ttttaattga cggaatgcaa agaagtcagc 2635261 ttgtatgtaa tgatggtccg gccttcttcc cattgaagct tctgcacttc agctgtgcct 2635321 gacttttcgc caaactttgt tttgcgtaca tccattggaa tctccatcgg atatactcgg 2635381 tatccgtcct tctctaacgt gaatatattt tcatctatgc gaacttcttt tccttttgtc 2635441 acaatcagtg tattaaattc aacaggcatt cccaaagtga aatccccttt cgttctcttt 2635501 tttctttatc ataacatatt tcactgtcag cggtttttca tccattgtgt gagctgccgc 2635561 acgatacgcc ggttttcttt tggcgggaaa taatgtgtga atgtactgta gtaccatgtt 2635621 tccaccggct tatgcagttg ttttagcttc tcttctaata aataggaatg ctgaatcgaa 2635681 acattttggt ctttttctcc atggattaac agcacgggag cctgaatttt gtttacttgg 2635741 tcaaacggtg tcctccattg atattcctca ggcacctttt tcggtgttcc gccgatgact 2635801 cttttcatca ttcgccgcaa atcctgccgc tcctcgtatg taagaatcat atcactgacg 2635861 cctccccagg aaacaaatga agctgcctgc ccgcccattt cgatcgcagt gagcattccc 2635921 ataattccgc cgcgggaaaa accgaagata tggattctat ccttcttgac atttgggtgc 2635981 tgctgaagca ggcgaaaagc agaaaatgca tcctccctgt cttctccggc aaaatcctca 2636041 ttgccttctc ctccttgatt gcctctgtaa aaaggagcaa acaccacaaa cccttgggat 2636101 gcaaactgga taatccggcc cggccgaacc atgcccacgc ttttaatccc gccgcgcaaa 2636161 tataaaaatc cgtcatattg tcccggttcc gccggctcag ccagaagccc cttaacccgt 2636221 aatccatttg acagatagca gatcgtatac aaacgcacat gctggcttgg cgacggaaat 2636281 cttcttttct ctacaatcaa aacagccgcc tccttttttc tatatgcttt ccttactcca 2636341 aaattacatc cggagaacct ggttaggcat tcacacattt ttatacccat catacgatat 2636401 gtaaagcaaa aaaggatatt aacttgatgc gaaataagga ggttgtctat gtgaacagat 2636461 ggttaaggct gggcttcgcc tgtgtcggca gtatctttct gatgttcgcc ctggcggctt 2636521 gcaagcagga agaaacgctc accaaagtca aagtagctga agtgacccat tcaatttttt 2636581 acgcaccttt atatgttgct gagtctaaag gtttttttaa ggaagaaggg cttgatgtcg 2636641 atgtgaatac gacctggggc ggagataaaa cgatgacatc gcttctttcc aacggctccg 2636701 acatcgcgct tgtcgggtca gaaacatcta tttatgtcga agcgcaaggg gctaaagatc 2636761 ccgtcattaa tttcgcccag ctgactcaga cagacggaac gtttcttgtc gcgagagaag 2636821 atgttgaaca cttcgactgg gatcagctga aaggaaaaac gtttctcggt cagcgaaaag 2636881 gcggcatgcc gcaaatggtc ggcgagtatg tactgaacaa acataagatt gacccgcata 2636941 aggatataga cctcatccag aacatagact tcgccaatat tgccaatgcg tttgcttctg 2637001 gaaccggtga gtatgtacag ctctttgaac cgcaggcttc tctctttgag aaaaaaggca 2637061 tcggccatat cgtggcttca ttcggagaag aatcaggaga ggttccttat acgactttta 2637121 tggcgaaaca aagctatttg aagaaaaatg aagacacagc cgtcaagttt acaaaagcca 2637181 tttataaggc gcagcagtgg gttgaaaatc attctgcgaa ggacatcaca gatgccatta 2637241 aagatgaatt tgatgatacc gacccagacg tcatcgaaac atccattgaa cgctataaaa 2637301 aacagcattc atattcacca gaccctctgc ttaacgaaaa agaatgggag cttctccaaa 2637361 ccattatgga taaatcggga gaactgccga agcacattcc atacaatcag cttgtaaata 2637421 aagaaattgc tgaaaaagtc acctcggaga aataggaggc gccatctatg tctttcttac 2637481 atgtcgacca tgtaacccat acttattttt ctattaaaga aaaaacaacg gctgtgcggg 2637541 atattcattt cgatgccgaa aaaggcgatt tcatctcatt tctcggccca agcggctgcg 2637601 gaaaaacaac attgctttcc attattgccg gtttgattga gccatcagaa ggcagagttc 2637661 tgattgaagg ccgtgagccg aatcaaaaag aacataatat tggctatatg cttcagcagg 2637721 attacttatt tccctggaaa tctatcgagg aaaatgtgct tctcggttta aaaatcgccg 2637781 acacgctgac agaagaaagc aaagccgctg cactcggtct attgccggag ttcggcctca 2637841 tagatgtgga gaaaaaatat ccgaaagaac tgtcaggcgg gatgcgccag cgggctgcgc 2637901 ttgcaagaac acttgcgcct aaccctagtc tgcttttgct ggatgagcca ttttccgcgc 2637961 ttgattttca gacaaagctg tctttggaaa acctggtatt ccgcacatta aaggaatatc 2638021 aaaaaacagc agtgcttgtc actcatgata taggggaagc gatagcgatg agcgatacga 2638081 tctttttatt ttcaaatcag ccgggcacca tccatcagat ttttaccatt cctaaggaat 2638141 tggccgcgat gttgcctttt gacgcccgtc aggaaccttc cttccagaca ctgtttcaaa 2638201 cgatatggaa ggagctgaat tctcttgaga aacagcaaag aaaccattga tctgcttcac 2638261 gagcagtatc aattcaaaca gaaaaaggaa aagtggaagg tccattcctt tcagcttgcc 2638321 atatttattc tctttttctc gggctgggaa atctccagca ggcagggctg gatcgatccg 2638381 ctgatcttca gctctccatc agctgtgtgg cgattattgc tggagaaact tggtgacggt 2638441 tctttactgt cacacatcgg cgtcacttta tttgaaacgg tgcttggctt tttgctcggg 2638501 acgtttatgg gcacgtgcct agccgctttg ttatggtggt ctaaccgact tgccagaatt 2638561 ttagatccgt atcttgtgat tttgaacgca atgccgaaag tggccctggg cccgatcctg 2638621 attgtcgcgc tcggtcccag ttttatcagc atcattgcga tgggagccat catcagcgtc 2638681 attatcacaa ccatcgttgt ctacaccgcc ttccaagagg tcgacgaaaa ctatacgaaa 2638741 gtcatgaaaa cattcggcgc aaaaaagtgg gttattttta aagaagtcat actgcctgca 2638801 tcctcccccg cgattatttc aacactaaaa gtgaacgtcg gtttatcatg ggttggcgtt 2638861 attgtagggg aattcctcgt ttcgaaggtc ggattaggat atatgattat ttacggattc 2638921 caagtcttca attttacact cgtcttctta agcctgctga tcatcgccat cttcgccact 2638981 ctgatgtatc agggcgtcga gctgctggaa aagaaatgga cgaaggggag gacataaaaa 2639041 acccggcaca tgtgccgggt tttttattca atccatccag attctttcag ttttttcaag 2639101 ctgatcggaa gaacggaatc cttcataata aagctgaatt ttttattgcg ggaaaggttc 2639161 tccggcagct cgtgaaacaa aaccgggcct ttcgtttcaa agtaatcagc ctgcttttca 2639221 agcttttcta tatctgcaaa atatatattt tttacaatca ctttttcttt tccgagaact 2639281 ttatactgtc cgagatactt gaggcttttg actctcgcgc ccgtctcttc ctttacttcc 2639341 cggagcgcag cctcttctgc gcactccatc ggctctactt tcccgcctgg aaactcatag 2639401 cctctgtcct catgttctgt taaaagccat ttgccgccaa aacggcaaat cacccagaca 2639461 tgcttcgggc tgtccgagaa aggctgatcg tcaaaggaaa gctgaacagt attctgataa 2639521 taatctttaa actcgtacat gtttatccct caaatccgtt cctagctatc ttccatacat 2639581 cataccacag ttacgtttct tcggaagcct tttatcaaaa aataagggaa acccagcacg 2639641 ccgtcaggtt ctgcatgcag actagctcgt acagtttttt tgcgatactt ttgccggaaa 2639701 gtgcgaccga cgctctgggc tttattatga cccgcgaaca gggaaaagtt acggtttgcg 2639761 cttaaattta ttttttaacg tttctaaaag atcgacaagc atctgaggaa ccggtatgcc 2639821 aagagagctg gctgtcacaa caatttgcac agattcataa agaatataaa acataatagc 2639881 caagtcacga attgatccct gtgtattcag cagctgatca aaaaagtggc atacagagat 2639941 cagagccagc gtgactaatt ttttgacaag ccgggcaaat acctttttaa atgacagttt 2640001 gtgaataatg gtttccttca aagtcgtact gataaattca attgccataa gagagagcaa 2640061 aatcagaaat gaatactgaa aacctccaaa gaaaaaaccc gctgctgaaa cgctgactgc 2640121 taaaaacgaa aagatgccaa agtctctatc catttatccc aacatccttt cacagaaacg 2640181 gccttacgat attctatggt aaacaagccg aacggattgg atttttcaga aaaatggact 2640241 ggttgtcgcc tatttttcag atacaaaaag aaaagccgga cgtctttttt aagacatccg 2640301 gccgttctat ttttgaactt aacctaggta agcttttagc atccagttat gtttttcaat 2640361 attttgatgg atcgcaagaa gcatgtcccc tgttgtttcg tcaccgactt catcagctaa 2640421 atccatgccg tttttcagct cttccgcgat gactgtgaaa tcatcatata cgctttgaac 2640481 catttgttca gctgtttcat ttccagcagc ttctttgaca gaagccgttt ctaaggattc 2640541 cttcattgtt gcaatcggtt ttccgttcag cgccaaaaga cgttctgcta agtcatcaat 2640601 ataagttgct gtttcgttgt acagctcctc aaacttttca tgaagagtga agaaatcttt 2640661 ccctttcaca taccagtgat aattatgtag tttcacatac atgaccgtcc agttggctac 2640721 ttgtttgttc actgcttgaa tcaattgttc tgacatggta tctcctcctt gttatatgac 2640781 tatgtatacc cttaatatcg tacgctaaaa cctctttttt acccttatct gtcacgattt 2640841 cttctattat gctacaattg ttaaaaaacg ggaggtggaa tgtcatgacg cttctcatta 2640901 cgataagtat tttgattgtg ctggctgttt tgcttgtaac catttggacg actgtaaaag 2640961 cctataatgt aaagcatacc attgatccac cacaagaaaa tcactctgat tcacacaatc 2641021 aatgatgatg tgaatgctcc tcttctgact gattgctggc agcatcggcg tctccgactt 2641081 ggacttttaa ggtcggcatg ctatgctgtt tttttgctgt gacatgagat tggacagtgt 2641141 atacaccatc ttccttaaac gtcgtttcca atcggtatac gcctttttct tgtttcacct 2641201 taaacatttg gcttgcgtct ttttcccctt ctttccatac ttcaaactct acttcatcgg 2641261 catccgtcac agcttcatca ccatatgata cagctgcttc ataagcagcg ctttctccgg 2641321 gatttacttt ttcaggcccg gtcagcttga catccaaaac ctcgggcgtc tcagctgtat 2641381 ttgctttact ttcaccagat ccgcatccat taagcaataa agcagaaaaa agcagaacaa 2641441 ccaacatctt tttcatgcca tcaccctttc atcgtttacc taaatagtag caaacgctta 2641501 cagcaaatgg tacacaaaat atgagacgtc acaaaaaaga cctttttgct taagcgcaaa 2641561 aaggtccttt ctattttagc caaatacttt tagcaattct tctttatcct gtgaaagcca 2641621 gaaacgcatt aaacgtttag cgccttccag atcatgaagc ttcgcttggc cgcactgctt 2641681 ttcattcgca gcaggtattt ctgtaatctc taccgcttcc ttcattgtgt cttcaagcag 2641741 atcaacgatt tccgctgatg tcggctctcc gctcacaact agataatagc ctgtctggca 2641801 gcccattgga gaaatatcaa tgatatcaaa atgatcgtat ttctcagcgt gagaacgaat 2641861 cgtaaacgcg agcaaatgct cgagtgtgtg aatggtgtca ggcttcatcg cctgtttatt 2641921 tggctggcaa aaacgaatgt caaatttatt tacaacgccg tctgttccca ctttatgcac 2641981 gccgcaatgt cttacatatg gagcaacaac cgcattatga tcaagctcaa aactttctac 2642041 tgaaggcata atggcactct cccctttttt aaaaatgtaa tttcattata acatactttt 2642101 ccgataagaa ttattgatta acttttcaat ctgtgttttt tttcttatac ttgcatcaga 2642161 aaggttgctg aagaaacatg aaaaccctat tcatcgctct gatcagagga tatcaaaaat 2642221 tcatctcgcc cctgacaccg ccaacgtgcc gcttttatcc gacctgttcc caatatggaa 2642281 tcgaagcgat taaaacacat ggcgctttaa aaggcggatg gctgacaatc aaacggattt 2642341 tgaaatgcca cccgttccat ccgggaggag tcgatcccgt tcctgaaaag aaacaaaaac 2642401 attaattgtt ataaccgttt acgataagat ccagttttcc ggttttagga tcaatgacta 2642461 agccatggac cggaacgttt tcagggaaca gcgggtgatg tttaataaca tctacgctgt 2642521 ctttcacact cgcttccact gaatcaaagc ttttaaacca ttgatcaaag tctacaccgg 2642581 agtactttat tgtttcgatg cgttcttccg gaatccctct tgctttgatt ttttcaagca 2642641 tgcttttgct gctgattttg ctcatgccgc aatcgtgatg cccgatcaca cacacctcat 2642701 ctgcattcag ctcgtacact gcgacgagta tacttctcat gatgcttccg aatgggtgtg 2642761 tcacaagcgc accggcactt ttaatgattt tcacatcacc gtttcgcaaa ttcatcgcat 2642821 gcggcagcag ttcaaccaga cgagtatcca tgcaagaaag aatcgccatt tttttatctg 2642881 gaaattttga tgtttgatac ttttcatact ctctttgttc agtaaatgtc ttgttaaatt 2642941 cgagaatatc atttagaaga ctcatgttcg ttgtcccttt ctattctttt tactcttcaa 2643001 tatatcacaa cccttgttta ttcgtcataa taaaaaaaga caaaccctca ggcctgcctt 2643061 atttccccat gttatagcgt tttttgaact gctcaactcg tccgcctttt tcattgaatt 2643121 tctggcggcc tgtataaaac ggatgcgtgt cagagcttac ctctacttta atgacaggat 2643181 atgtgtttcc gtcctcccac tctgctgttt cattagatgt tttcgtagag gtgcttagaa 2643241 aacggtagcc gctgttgaca tcctgaaata tcactttgtg gttctttgga tgaattcctt 2643301 ctttcatggg tatctccttt caataaatcg taataattac gttttatttt ataaccttac 2643361 aaacgttttg tcaatcttct tatatccttc cctctgtttc acatcgtaaa cctcatggca 2643421 tttaagaata ggaagaataa tctaaccgag gaagcaaata ataaacccaa aatacataca 2643481 gaacgtcttt ttggaaaggt ggtttacgat tgtggatgat ttagttttgg ccagaagcct 2643541 ttttggcacg acgatgggct ttcatatcat tttcgcaaca cttggagtcg gtctgccgct 2643601 catgatttta gtggcggaat tgatctatca aaaaacgaaa gatgaccatt atgcgatcat 2643661 ggcgaaaaga tggacgaaag cacaagccgt tttgctgggg gtcgccatac cgaccggaac 2643721 gatcgcgggc actcagctcg cgcttttatg gccgggattt atggaagtca tcggccgggt 2643781 gatgtccctg ccatttcaaa ttgaaatcta tgcttttttt gttgaagccc tattcatgtc 2643841 gatttatgta tacgctgcag accgtttgtc acctgcaatg aggattgttg ctgttttctt 2643901 tgtgttagtc ggggcagcag catccgctgt tctgatcacg aatgttcacg cttttgaagg 2643961 tacgcccgcc ggttttaaaa ttttaaacgg aaaaattaca gatgttgacc cgtgggctgc 2644021 gttttttaat cctagctttt ttatcactgc cggccatgtc gtgctgtccg cgtttatgac 2644081 tggtgcgttt atcgtggctt ctgttgcggc gtataaaatg atccgaacga ggaaaaagga 2644141 aagggtctat cgctttcacc ggaaagccct tttgctcgca ctgacgatcg gcggtatttt 2644201 ttcattgctg accgctttga acggacacga atctgcacag atgctgtacg aataccagcc 2644261 cgaaaaatta gccggtgcgg aaggcctatt tgaaacaaga tcccacgccc cgctcgctat 2644321 cggcggtttt accgacccga atgaagaaaa agtaaaatgg gcaatcgaga ttccatgggc 2644381 tttaagcttt ttggcagcga accgttttga cactgttgta aaaggattaa atgcatttcc 2644441 gagagatgaa tggccgccgc ttttcattca cacgctgttt aatgcgatgg ttggtgtagg 2644501 catgctgcta attctttatt ccattatcgg tgtggtctgg agaaaggtgc tcaagaaaga 2644561 ccgtttccca acgtggcttt tgatcatttt catgacagca ggccctttta gtctcatcgg 2644621 cattgaattc ggctggattt tcgcatgtac ggggaggcag ccttgggtca tctatcatct 2644681 gctgaaaacg tcagatgtcg taacaacgac tggctcgatc ggggtgctgt tcttattttt 2644741 cacatttgtt tatgccgtgt taggcgcagc tgtcgtctac gtgctgctgt attatttccg 2644801 caagcacccg gttgacgaag atttaaatac agcggagtcg taatggctcc gcaaacagga 2644861 aaccaaatgg aaggaagatc gtacaaatgg agatttcaac tgacgctctg atcgccatct 2644921 caattatctg gggctttgtg tttatttacg ccgtcatggc gacaatggat tttggagcgg 2644981 gattttggtc tatgatctat ttaaacaagg agcatatgaa ggccaccgat attgcgaatc 2645041 gctttttgtc cccgacttgg gaggtcacaa acgtctttat tgtggccatc gtcgtggcgc 2645101 ttttcagttt tttccccggc gcgacatttg tgctcggcac cgttttatta attcccggaa 2645161 gcatgatttt gctgctttta gcaattcgaa gcggatttct cgtgttttca aatacagcaa 2645221 aggagcggaa aacgctaaga tatatttccg gcatctccgg ctttatcatt cctgctattt 2645281 taattttggt gcttcctgtg acacacggag ggtttataga aaaaacggat ggaatctata 2645341 acttaaatat gtctaaaatc ttttcaagcc ccaacgccta ttcatttatc gggtttgcga 2645401 ttttaagcac cttatttttg tcctcgctgt tgcttgcaga tttttcaaat gtggcagagg 2645461 aacaggatgc gtaccgagcc tacagaaaaa gcgccctgat taccggcccg atttcactgt 2645521 tgtttgctgt atgcattatg gtaactatgc ggaatgaagc aaactggctg tacagcggaa 2645581 tgatgaatga tttttcttgg attattgcat cgttcattac atttgtcatt gctggaatcg 2645641 ctctttttct gcctaacaaa agctttggtc aaaacatcgg aaaaccgcgt ctcgcacttg 2645701 ttgcgattgg gatacagtat tttctcgcaa gctacgcgta cgggcgggcg catcttccgt 2645761 atatgattta tcccgatgtg acagtcatgt caggcttcac agagccagca acgttcagag 2645821 cgctgtttgc aacgtatatc gttgcattta tcattctatt tccgggcttc tttttcttct 2645881 ggaaaatgtt tatgcgagat aaacgctata tccgccagga ggaatagagg gcaagccagc 2645941 cggctatact aatccagaac ctttataagg aggggatggc atggagcaga aaattctatg 2646001 tgaggtcaac aactgttctt attggggcaa aggtaacaaa tgcaccgctg atgccattta 2646061 tgttgtcagc catactggtg aaacggctga aaacagccgg gaaacagact gcaaaacgtt 2646121 taagccgcat gatttataat taaaagaaag agctgcatca gccagctctt tctttttgca 2646181 tgttgagtgt tctcagcttt ttagttatga ccccgtttgc aggtgaaaac aaaaaggcgc 2646241 ttgcataaca tacacctgtc atggccgcca tcgctcctga aatcgaaaca ttaagccacg 2646301 ttgcgaagaa atagcccatg accgccgaca gcccgccaat caacgcgctg agaatcagca 2646361 tataaagaag ccggtctgtc agcaaatgtg ccgcagccgg cggaacaatc agcatggcca 2646421 caaccaatac ggcacccacc gaatcaaagg aagcaacagt cgtcaaggac agcatgccca 2646481 tttgcacgta atgaatgagc aaaaccggta ttcccaaggc taaagccatt tgaggatcaa 2646541 acgaagcgat tttaaactcc ttatagcaca cactgatcaa cactacgttt aaaaccagaa 2646601 cagatgccag catccaaaac gctttcggcc caatatcaac cccgaatacc gtcaccgtat 2646661 tccacggcac aaaagcgatt tctcccatta acgagtgctc aatatcgaga tggacattcg 2646721 ctccatacac agaaagcaaa ataaccccga ttgcaaataa ggatgtaaac acaactccta 2646781 tggcagcatc tgattgaacc cccttgctat gaagaagctg aaccaagaaa gccgttaaca 2646841 gaccggttgc ggctgcgcca ataaacatat aaatcccatc gagacttccc gtcactagaa 2646901 aagcgccgac aatgccaagc aacactgtgt gactgattgc gtcggccagc atcgccatgc 2646961 ttctcagcac aagaaatgtg ccgatcaatc cgcagcttac accgactaat acaccggtag 2647021 ctataatcca tgcttcaaaa ctcatttgcg atctgtccct tctcggcatc atgagacgct 2647081 tttcgacgct caggcatccg tccatacagc tttaagagtg aataaagccg ctctctcgtt 2647141 tctctcggta aacggtccgg gtcaaagtag tcctgatcgg attctatatt ggcaagttcc 2647201 atttcatgca tgagatacac ttcatacatc cgctgcttca aagctgtgtg atagcctttt 2647261 tctatccctt tgcttgtgat ttgccaaatc ccattttcga tacgctcaat gcacctctct 2647321 tgttccaagt catttaatgc cttaaggcat aatgaagggg ataggcgtct tttctttctt 2647381 acactttcaa cagttacaca aagattattc ttttcatact gttcataaat cgccaaaagc 2647441 acttgctccc tgcttgttct gcgccgcagc ctcatcagcc ttatggcttt agcagccaat 2647501 ccccgcttag gcgcgcaaat cattgaaaaa agaaagagca gcgttgcaga taagatcatt 2647561 aatggccctg tcgccattcc cttcatcgtg gtgctaagca gggttccggc cactccgctg 2647621 accccgcctg taatcccggc aatgatgatc atcccggtta atcgttcggt ccaatatctc 2647681 gcggttatgg caggtgtaat cagcatagcc gccattaata tcacaccaac agtctgaagc 2647741 ccaatgacga cagcacagac aatcagacaa gccaaaagcc cgtttaaaaa acgcaccggg 2647801 attcctaatc cctttgcaaa cgcgagatca aaagtaatca atgtaaattc cttaaagaaa 2647861 acaatacata ggagcagtag aacagcggat atccctgcaa taaggatgat atcctgcctg 2647921 accaatgaag cagcctggcc gaataaaaaa gaatcaagcc cgctttggct tcccgccccc 2647981 tgttgctgaa tatatgtcag cagaatgatc ccgacgccaa aaaacacaga aagaacaatc 2648041 ccgatcgccg agtcctcctt tgtttttgaa agccgaggaa tcagctgaat acaaaacgtt 2648101 ccgagcagtc cggcgagcgc tgcccccagc aaaaagaaag gcagtgattt ttgcccggtg 2648161 aacagaaaag cgagacacac tcccggcaga gctgaatggg ccatcgcatc gccgattaaa 2648221 ctttgctttc tcagcagcac aaagctgccc aaaacaccgc ttgccgtccc gagcaaaagc 2648281 gtaccggcca gcacccactg tgtattcgga tgctgaagct gcagccacaa actttcaaac 2648341 attgcgctca ctccttatgt ccttctgcca gcactttatc ttttaaaaac gtaagccttc 2648401 ctccatatgt tttttgcagg ttttcgatcg taaaaacgtt ttccgtcggt ccgaaagcga 2648461 ttttccttaa atgaagcagt aagatccaat cgaaataatc ctcggcggtc tgcagatcat 2648521 gatggacgac aagcacggtt tttccttttt ctttgagttc tgccaacagc gtcataatcg 2648581 cgcgctccgt cgctgcatca acacctgcaa acggttcatc cataaaataa atgtcagcgt 2648641 tctggcagag tgcccgggca agaaacaccc gctgctgctg tccgcctgac agctggctga 2648701 tttgcctttt cgcataatca tgcatcccga cttttgttaa tgcggccttc gccatctcca 2648761 catccgcttt ctttggcctc tttaataaac cgattctccc gtatcttccc attaggacga 2648821 catcgagcgg gcttgtgggg aaatcccagt caaccgagcc gcgctgcgga acatatccga 2648881 ttctggtccg ctgatcctta tagtctttgc cgtaaataga gatgtctccg gaagctctgg 2648941 gcacaagacc gagaatcgtt ttgatcaagg ttgattttcc cgcgccgttt gggccgataa 2649001 tgccaataag ttttccttca ggcacctgca gcgaaatgtc ctgcagtaca ggctttttat 2649061 gataagcaac cgtcacatta tcaagctcaa cagggaacat atcctccacc tcttttcttt 2649121 atttaagcgc tttagtaatc gtgttgatat tgtggcggaa cattccttcg tatgtgcctt 2649181 cttttgtgcc cttttcaccc atggcatccg aataaagctg accgccgatt gtgactgtat 2649241 ggcctttttc tttagcgcct tccaccactg cattgattga tttttcagat acactgcttt 2649301 ctacgaacac agcttttatt tgtttttctg tcagaagatc aaccagctcc tgaacatccc 2649361 ttaatccata gtccgaatct gtgctgagtc cctgcaggcc ttttacctta aatccatact 2649421 cattcccaaa gtacgcaaac gcatcatgag cagtcacaag cacacggctt ttctccggaa 2649481 tatgtgcgat ctccttacgc gaccacttat ctaaatattg caaatcttct ttgtactctt 2649541 tggcattttt ccgaaaggca tctgcgtgct gaggcattgc tttgctgaat tgcgcttcaa 2649601 tttcatccac cgcatagatc cataacggaa tgctgaacca gacgtgggga tcaaacgtct 2649661 tgccttcccc cgcgggaata agcttatttt tcggaatggc ctcagctact gccgccgatt 2649721 gtttttgttc gccgattttt tggaggacat cctccatttt cccttccaaa tgcaacccgc 2649781 tgtacagaac aacatcggca gacattaatt ttttcgtgtc accttgggaa gctttgtaaa 2649841 ggtgcggatc aacccccggt cccattaaag aggtgacttt tacgtgctta cctccgatgt 2649901 tttctgctgc atcggcaatt tgagatgttg tcgctgtcac ttgtaattgc tgatcagcgc 2649961 tttttccggc tgaatccgtt ccgcatcccg ttaaagcaaa ggtcgcaaaa agtactgctg 2650021 ccatcagccc ttgtctcata tttctcctcc tctttgccat caatgtccga ttgttttatc 2650081 ttatgttgtc agttcttaga catgtgacat taaattagcc aaaagcatgt tttatttaca 2650141 caggacaaaa agtttccctc atgcaaaatt atcgcgtttg gccatttttg tcaagctgat 2650201 ttacataaaa aaaccggctg ggtcagcagc cggtccaaac gagaagggat gtattcaacg 2650261 aacactttta ctgtaacagc acagtgtcat ttattcaaaa tagcaaaatg cttttttctt 2650321 aaccatgctg tgtgaaaaca tccattttgg tcacatattt tcgcataata tcttggttta 2650381 cctcaacccc taaaccaggc tgttttgaca cagaaataaa tccattatca atacgaatat 2650441 caggagttac aatatcttca tcccaatagc gtgaggatga agatatatcg ccaggtattg 2650501 tgaattgagg cagtgaagca agcgccacgt tctgcgctct tgatatgcct gtttccagca 2650561 ttcctccgca ccaaacctgc atatgatgct ctttgcataa atcatgaatt tttaaggctt 2650621 ctgttaagcc gccgacacga gaaggtttta tattaataat tttgcagctt cctagctcaa 2650681 tcgcccgtct cgcatcatca actgaacaaa tgctctcatc aaggcaaatg gccgttttca 2650741 aatgtttctg caagtggcgg tggtcaacga tatcgtcagc ttggagcggc tgctcaatca 2650801 tcattaaatg atagtcatca agctccttta aacggctgat atccttcagt tcgtaagagg 2650861 aattggcatc ggccataagc gggatggttg ggaatcggct gcggatggcc ttgaccaatt 2650921 ccacatcctg cccaggctga attttaattt ttattctttg ataaccttct ttttgatagc 2650981 tctcaatttc cttcagcata tcgtcaagag gcgccaggcc gactaccacc ccggcaggga 2651041 ctttatctct tgttccgccc aatgcctcag caagggatac gcccttcttt ttggcataaa 2651101 tatcccatac agccgattca agtcccgctt ttgccatccg gtttccttta taccgcgcca 2651161 ggctgtccgg cacttctgaa gggtgattga attcacggcc gacgacattt gggataaaaa 2651221 aatcttttag catatgcaaa catgttccaa tggtttcctc ggtgtaccaa ggcgaagaga 2651281 aagcggaaac ttctccccag cctgtgacac ctgatgtatc aatggcttcc acgatcagaa 2651341 atttacgctc ttgaagcgtt tcgatactgt ttttaaacgg tttctttaag ttcatgctca 2651401 aatggtaaag cgtgattttt tctatttcga tcatagcagt tctcctttac gcgcatcctt 2651461 cagctgattt cgcaagagct tattagacgc attgcgcggc aggcggtcaa gcacaaagaa 2651521 ttttgccgga attttatact tcgccaagcg ttctttgcag tagtcagtca attctcctgc 2651581 gctcacaggc ttgtgaagga caagataggc gtgaggcact ttcccccatt ttttgtcctc 2651641 agcccctgaa accccggctt cggccacagc ggggtgtgaa agcagcactg actccacttc 2651701 ggccggataa atgttttctc cgccggatat gatcagatct gaacgtctgt ctaatacata 2651761 taaaaagcct tcattgtcca aataaccaag atcacctgtt ttcagccagc cattttgaaa 2651821 ggaggcttcg tttgcgctct cccggttaaa atagcttttc atgacattcg ggcctttgac 2651881 catgatttca ccgtgttcat acggttcaca tacctgtccg tcccgctcta ttttgatttc 2651941 acacgaaaac agcggtttcc ccgcagatcc gagcttttcc atgctgaatt ccggcgacag 2652001 ggtaacaatt tgcgagcatg tttctgtcat tccatatgac tgaaagacag ggaatccttt 2652061 ctcacggcat tcctcaagca atggcagcgg tgcaggaccg ccgccgagaa gaatgcatct 2652121 gatggattca gggcagcggt ttgtttcttc caaaagactg gccagcatag tctgcaccgc 2652181 agatatcatt gtcacttcat gcctgttgat agaatgcagc acatcgctta cggaaaaacg 2652241 ctggtgaagc acgacagtca ttccatagat cacagattta aataatgcgg acaatccgct 2652301 gatatgaaag agcggcaatg cgataagcca gcggtcttgt tctgttatac ccaaattaag 2652361 agcggacgac accgcactga aataatggtt tccgaacgtt tgctgaactc ccttgggctt 2652421 tcctgtcgta cccgacgtat acatcagcgt tgccgttgca tccatttgca tataagcctc 2652481 gatctcaatt tcctctgctg cttctttcat cagttcatcc acatcaatcg tttgaacgat 2652541 gtgttcatat tctttcttct caaagcttga atctgtcaat aaaaagccgg atcccgaatc 2652601 ctccagctga aacagccttt catgtgttga cagcttcgta ttcaaaagca ccgccttaac 2652661 accaagcaaa aaacaagcgt gaacagcgta taccatttct gcacggtttt ggagcaaaat 2652721 agctgcagta tcccctttcc gaaccgaatg agcggcaagc tgttccgcca ttcgtttaga 2652781 cgcggcaaac aattctgcaa atgtcacggt ttggtcttca tagatgagag cgattctctc 2652841 aggtgtcagc tgtgcccgct gcatgagcca gttgggctgt tctgtcagca tgtcatcatc 2652901 tccgaggtaa aatgtctgta ttgaaaagaa aacagcttgg accgcaaagt ctcaagctgt 2652961 tggtttacta gatattgctg atcacggaaa acgagggaac tgtccgaaat caggtttgcg 2653021 tttttcctta aaggaatcac ggccttcttt tgcttcatct gttgtgtagt aaagaagggt 2653081 agcatcccct gcaaactgct gaattccagc aagtccgtct gtgtccgcgt taaacgcagc 2653141 tttaagaaag cgcagtgcgg tcgggctttt ttcaagcatt tcttcacacc atttaatcgt 2653201 ttcttcttca agctgttcca aaggaacgac tgtgttgaca agacccatgt ccagtgcttc 2653261 ctgtgcgttg tactgacggc ataggtacca gatttcacgt gcttttttat gtcctacaat 2653321 tcgagccagg tagccagaac cgtaacctgc atcgaagctt cccactttag ggcctgtttg 2653381 tccaaaaatt gcgttgtccg cagcaattgt caagtcacat acgatgtgaa gcacatggcc 2653441 tccgccgatc gcatatccgg acaccatcgc aacaaccggt ttcgggatga cgcggattaa 2653501 acgctgaaga tccaatacgt taagacgagg gatctggtcg tctcctacat atccaccgtg 2653561 gccgcgcact ttttggtctc cgccagaaca aaatgctttg tcccctgcac cggcaagcac 2653621 gataacccca acgttttggt cgtctcttgc gtcagcaaac gcatcaatca tttcagcaac 2653681 cgttttaggg gtaaacgcat tatgtacctc aggtcggttg attgttattt ttgcaatgcc 2653741 attatacgtt tcatacaata tctcatcgta tgtccgtttt gttttccatt cagccatatg 2653801 atgacctcct tttattctct atgtgaatga gtcagatgct tgtcaaaaac tcactcacta 2653861 ttttaccaaa caatcgcggc tgctccacat ggaccgtatg tcctgctttt ggaacaatct 2653921 ctattctact agaaggaagc atcttatgca cctcttgatt gatggcgcaa aatttttcgt 2653981 cccactcccc gcagatcaga agcacaggaa catctatttc ctctacacgg ctccacaagg 2654041 aaggctgtga accggtgccc atgccggtta aactgttcgc aagcccaatc ttattgttcc 2654101 gcagacggcc cgatcgtatc ctgtaccgaa tatcttcagc cagcctctgc tgagatgaaa 2654161 acaaagggat attctcccaa tacgcaacaa acgcttcgag cccgtctcgt aaaataaaat 2654221 cagcaagctt ccggtcccgc atgattcgtt cccgccgttc cccaagtgtt ttgagccccg 2654281 gcgtcgtgct ttcaagcaca agtgccgata cccgctcggg atatgtcatc gcaaaagagt 2654341 aagcaagcct tcctcccata gaatacccaa tcaatttcac tttgtgaagt tttaattgat 2654401 caaaaatctc ggcaaggtca gaaacttgcc gggttgtgct gtatcttttc ccattcagcg 2654461 gggcatcggt ttccccatgc cctaaacaat caattttgat caaacgggaa tcaggcagca 2654521 tttcatcaag aaaagtccat gattgtttgc tgccggtaaa cccatgcaga cagacgacgg 2654581 cttcggaagc attcggtccc tcgtctgcca ctgcatatcg gacaccatct gataccgtta 2654641 tgtttacagt tcccattgtt ttttcacttc ccgcacagcc tcattcagca tatcgcgatg 2654701 aagctggact cttgattggc gatccgtttt gatttcaatc aaatggagtc cgggcttgtc 2654761 tgcctgcggc gcgtaagctg ttttgaattc atcccaagaa gccgggcatg aatacgttcc 2654821 gccgtaaagt gcagccgcat gcttgaaatc gagccctgtc ggtgtgccga acaaatcttc 2654881 aaagtgtgtc ttctcagaag cctgcggcaa aaaggagaaa atccctcctc cgtcattatt 2654941 gacaagaatc acagtaagag gaatacccag ctttttggcc gccagcaggc cgtttaaatc 2655001 atgataaaaa gataaatctc caatcacaag ggtaacaggc gcttttgttc cttcacatac 2655061 ccccatggca gaggagacga caccgtctat cccgtttgct ccccggtttg aataaatccg 2655121 gaaagggcgg tcctgctttt caaaaaacgt atcaacatcc ctgatcggca tgctgtttcc 2655181 cacaaacagc gagctgtttt caggcacaag atgctgaagg attcgataga gattgccttc 2655241 aaacgaaaca tcttcactgc tgattgtttg cagatgctcg cggaaccgcc cattgacaaa 2655301 ctgccacttt tccagccact ctgaggatct ggtggcagca gtaaggcctg ccatgatctc 2655361 ctcagcaaaa acagacgcat tacaatgaat catatgcgcg cttgcctgtg tcgggtctct 2655421 ccaccctcca tcctcgtcaa tcacgatttg ctgaatcgtc ggatcatcct taagccataa 2655481 gaaaaccggt tttgaaacag gcatcggtcc aaaccgaatg acaacatcag gacggagttt 2655541 ccgcttcagc tcatcatctt ttaaaaacga atcatacgca tcaataacag tgcttttatc 2655601 atgaacacca ttccgcagat tagacagcgg atctgctaaa attggatact gaagcgcttt 2655661 tgacagcgca ataatgtttt ccttgtccgc atcactatgg agctctccgc agacgatcat 2655721 tcctttttca gcctctgcga gcatctcagc cacatcagac agggactctc ggtcaacaga 2655781 ctgcgtaccc gttttcacag acacatgacg gcctgttctc attcttccaa acggctcatc 2655841 tgaaagatcc ggcatcagcg gttcgcgcag cggcacattc acatggacag gccccatcgg 2655901 gcgcttttgt gcttctccgg cagcgcggct tgccagcgtt cggatgtatc tcagcatttg 2655961 cggagactct tcaggaagag cagagtctgt gaaaaactta acaaagttac cgaataagaa 2656021 gtgctgatta atagcctgcg gtgcgcctac ttcgcgcagc tcatgaggcc gatcagcagt 2656081 taacacaata ataggcaccc ttgaataatg ggcttcaacc acagccggat aaaagttggc 2656141 cgcggctgtt ccagatgtac agatcaatag tacgggacgc tgcttcgctt ttgccaaacc 2656201 taatgcaaaa aatccggcag acctttcatc aatttggaca tggacgctga tatcgggatg 2656261 cgcagcacaa agaacagcca gcggtgtaga tcttgagccc ggacaaacga cggcgtccgt 2656321 aattccggaa agggcgaatt catcaataaa acttccgatg taatgagtaa tcgggttgac 2656381 tgtcaacgcc tctcacctcc taatgcagag atcatcggct tcaatttaat ctgtgtttct 2656441 tcatattccg agattggttc cgagtcttcc acaataccgc acccggcaaa cagccttgct 2656501 gtgcttcctt cgatgagccc tgaacgaatg gcgaccgcga attccccgtt atcctggctg 2656561 tcaatccagc cgataggggc cgcataccag ccgcgggaca tcggttcaat ctccctgatc 2656621 acgtcaacag ctttttcctg aggtgatccc ccaagcgcgg gagtggggtg cagcttctca 2656681 attaagtcaa aaatcgaagc agactcgcgc agctgtccga caatcggcgt aaacaggtgc 2656741 tgaacgcttt ttgttttgta caaaacaggt ccatcaggct tttcaacctc tgaacagctt 2656801 gatacaaaag cattatgaat catacctacc acaatatcat gctcaagcag gtttttctca 2656861 tcgtttaata attcaaggcc tatccggcgg tcgtcttctt cattcacgcc tcgtttaatg 2656921 gagcctgcca gacaggaaga catgacagtg ccgccgtctc ttttgatcag tctttccgga 2656981 gacgcgccga caaaggtttt gccttcttgt tcaattgcaa aaacatagct tgtctgctga 2657041 tcgtccagaa gcgttttaag caccggttca atttggattg gaccgtcaaa cgtgagcagc 2657101 agctctcggg caagaacaac cttatcatat tgtttctctt taatttggct tgtggccgtt 2657161 tcgattgctt tcagccaatc atccttatcc agctcttcgg ctgctgcaat cacagcctga 2657221 tcttcttgct tgaaatcggg aaccataaat tccgccgcaa aagcttttaa gccttctaaa 2657281 acagcttctg cgtcttctcc tccgcttacc catctgttaa ctgttaagaa cgggccttca 2657341 gcagtcatcg tcagcataag cgcaggcaca aagaaatccc cttccgagaa atggtcccat 2657401 tgtgaacctc tttcttcgca agggtcaaaa gaaaatcctc cgaataacac aggtcccact 2657461 gcagaatgct gcagcttttc ttcttcataa atatgaaaag ccgtcttttt aaagcgctcc 2657521 cattgttcaa aaacctcacg ataccgctcg ctgttttttt gatttgtctg gaaaaccgct 2657581 tctttgccaa gaccgactat tgtcaattca ctttcaggat ctgaccaaaa aaatcgattg 2657641 cctgtatatt tttttgctcc gtaattgaaa aatgatagag ggtcaagaga ctcgatttgt 2657701 ctcgaatagc ttattaagac agcatggttg acttctttgg ctttatgtaa tgcatgtaga 2657761 acttcctttc ggaacgtacg ctgcaccgtt gtcaccatga gacattcctc cataatcctt 2657821 aaaatgcttt taataccata cacctgtgtc tcctttgtgt caaacacaga tcatgcagtc 2657881 caaatggcct gccttaccta ttataaacct aatttcagaa atgaaaaaga aacaaagctt 2657941 aaatttcttt ctccactgat agcaaaggtt gtatccgctt accataaaag gaaaacctcc 2658001 tatattcctc cacccgccat ttatgaaagt tctcaggcga tctgttcata ctaaaggtat 2658061 gcatcacaga gaaacgaggc gatcacattg cttacgaaag aacagcttca gcatttaaaa 2658121 aatgaactgg aacaaacgaa aaaagatatc ttaaaccgtt tcaaagacaa tgatcatttt 2658181 cagcttaact cagcctttcc ttatgattcg tggggtgagc tttcggcata cgacaaccat 2658241 cccggcgatc aggcgacaga actttacgag cgtgagaaag acatcgctct agacttgcat 2658301 gagagagagc accttcggga cattgagcat tcattgaagg cgatagaaaa cggtacgtat 2658361 ggcatttgtg aagtcagcgg aaaggaaatc cctttcgaac gacttgaagc gcttccgact 2658421 gccacaaccc tcgcggagta ttcgtcacag gacgtggttt ccaaagaccg tccgattgaa 2658481 gaagaaacac cattcgggca atttgaattt gatgatgatg aagaaatcag agcgccatat 2658541 gacagtgagg attcctatca ggatgtcgaa aaatatggga actcacaaac gccgcaggat 2658601 atggaaaacc ctccgctcag ctatgatgat atgacgatga atgccgaaga gaatatcggc 2658661 aatacggagt cttacgaaaa tttcatcgct acagatatca ctgggaaaga aattaccgtt 2658721 tatcaaagca gagcccatga gcgctatgaa gaagaacttg acgaagaggg aatcatgacc 2658781 acattcggcg atctccacgc tgattgaacc cccaattatt gggggttctt ttccgttttc 2658841 agcatatcgt aaatcagctt cagataatcc ttttgcaggc cgatgtcata ccgctcgccc 2658901 tctagcaatt tcccgtatac ggtacatgcc ccgagcgaag cttttatcgc atccgttacc 2658961 tgcacttctc ctccgctatc agcttctaat gcctccagct cattaaaaat atccggtgtg 2659021 aaaatataac gccctgctgc ggcaaaatga gacggagggt tttgtttagg cttttccaca 2659081 atatcctgta tgcgataaag ccctttttca acaggctccc cttttatcac cccgtaatga 2659141 tgtaaatcct ccgtttttgt ttcttttaag ccgatcacac tggactgata tttcgtatac 2659201 gcttcaatca gctgccccaa agccggctga ttggcggaaa aaatcagatc atctggcaaa 2659261 acgacggcaa aaggctctcc tcctgcaaat tgctttccga aagaaatggc gtcgccaaga 2659321 ccctttgcat aaggctgccg cacatagtga atccgtatat ccggaatggg atgctctcta 2659381 agtaaatgca gtttattctt agaggccaaa aaagcctcaa gtgccaaaga ggaatcaaaa 2659441 tagtcgacaa tcagattttt atggctcgat acaaccatca aaatgtcctc aatgcctgac 2659501 tcctttaatt cttcaacaag ataatgaatc acaggcttag atcctaccgg aaacatttct 2659561 ttcggaatca ccttcgtcac cggcagattt ctcgtgccga atccgcctgc aggaatgatc 2659621 gcttttttta tcatggtatt ttcccctcag ctcatgttta ttacatgata ttccaagagc 2659681 gcatcccgat gtttgtacat ctgaaattag gcggaagcaa ctgggcagaa agcggaatca 2659741 cgaaccagcc cttttttaat aggatattga tatatgacca gtaatcttgt aaaggagctc 2659801 aggtgatgaa aatttgtgtg gttggcgccg ggtatgtcgg tttaacccta tcagcggcac 2659861 tggcatccat cggacatgac atgatatgca cagacaaaga cgtcaaaaaa atcgggcagc 2659921 tgaaaaaagg agtcattccc ttttacgagc ctgggctttc agatgcaata cttcgttgcg 2659981 gcaatctctc gttttcttct gaagtgaaat cgagcatgga ggaatgtccc gttattttta 2660041 tcgcagtcgg aactccgccg cgttcggacg gatcagctga tacgaaagcc ctgcagtccg 2660101 tcatcggtga tttaagcgag gcgatccgat cgtataaaac cattattacg aaaagcactg 2660161 ttccgcccgg gacaaatgaa aacatagcaa aacagctgat tgcctccgga gtgtctaaaa 2660221 acctctttaa tatcgtatcc aatccggagt ttctgcggga aggcaatgcc ttatatgaca 2660281 tgctgcatcc tgacaaaaca gtcatcggtg ttcaggaaga agatcacgta tcggcagcca 2660341 tcgtcaaatc catttacaaa cacattgata ccccttttat cgttacaagc ttagcgggag 2660401 cagagctgat caaatatgcc aacaatttct ttttagcggc caaaatttcg ttcattaacg 2660461 aaatggcccg catatgtgaa gcctatcaat cagatatctc agatatttcc cgcgctatcg 2660521 gtctagaccc aaggatcggg aagcactttt tgcaggcagg catcggatac ggaggctctt 2660581 gttttccaaa ggatctgcag gcgctgcaat ttgctgccca ggaaaaaaac acggagacct 2660641 tcctgctccg ggccgtgcag cacattaatg acacccagct tggcctgtat atcaaaaaaa 2660701 tacagtcatt cttcgaaaca cttcaaggca agaaagcggc tgtactcggc atttccttca 2660761 aaccgaatac tgatgacatc cggaattctc aggctgtcag actgatggaa aggctggcgg 2660821 agctgggatg tgatgttcat gcatatgatc ctgaagctgt acttccagaa catttgcggc 2660881 aacatgtaac tcagcattct caagcttttg atgcgatcga agagagtgac tttttatttt 2660941 tggcgacaga atggtctgag tttttagcgt ttgattggaa aaaggctgca gatatcatga 2661001 aagggcgtct tgtgattgac ggacgcaacg tactaaaaaa agaactgatc gaggcttgcg 2661061 gcctgatctg tacgggagtt ggccgtccat gaaaatactc gtcacaggag cagcgggctt 2661121 tatcggctcc cacctctgcg aagaattact aaaagataag aaacataacg ttatcggaat 2661181 cgatgacttt atcggtccta ctccattttc cttgaaatta aaaaacctta aaaacctgct 2661241 gccggaaaag cgatttacgt tcataaagga aaatctgctg acagccgatc ttgcttcctt 2661301 actggaagga gtggacgtca tctttcattt ggcggccata ccgggtgtcc gctcaagctg 2661361 gggcaatcat tttcacccat atgccgcaca taatatccaa gcgctccaaa ggctcctcga 2661421 ggcgtgccgg gaacattcta ttcaaacgtt cgtctttgca tccacctctt ccgtctatgg 2661481 cgaaaaacaa ggaaaagtca gcgaaaacac gtcgctttct cctttatctc cgtacggggt 2661541 aacaaagctt acgggagaaa agctttgcca tgtgtataaa cagagctttg gcattccaat 2661601 tgtgattctc cgttttttta ccgtatacgg gccaagacag cggccggata tggcttttca 2661661 ccggctcatt aagcagcacc ttcagcaaaa gccgcttacc atcttcggtg atgggcagca 2661721 gtcaagagat ttcacttata tcagcgactg tgtcaaaggc atcaccgctg ttcttgggaa 2661781 accccacctt attggtgaaa cagtaaatat cggcggcgca gagcgtgcct cagtcttaaa 2661841 agttgtctcc ctcattgagg atatttccgg gagaaaagca acactgcact tttcggacaa 2661901 aatagcaggg gaaccgagca acacgtgggc ggatatttca aaagcaaaac agctcttgca 2661961 ttatgatccc gccacatcct taaaggatgg cttgaccaac gaaatcgcct atttatcgtc 2662021 gctgtatcag ggggaataaa aatgaagctt gcctttatct gtacagaaaa gctgccggcg 2662081 cccgcagtac gcggcggcgc tattcaaatg atgattgacg gtgtcacgcc ctatttcagc 2662141 agcaggtacg acctgaccat tttttcaata gaagatccat cgctcccaaa aagagaaaca 2662201 aaagacggcg tacattatat ccatctgcca aaagaacatt accgcgaggc ggtagccgaa 2662261 gagctgcgag cctcttcctt tgacctcatt catgtgttca acaggccttt aaatgtctct 2662321 ttatataaaa aagcctcacc aaacagcaag atcgttctga gcctgcataa cgaaatgttt 2662381 tctgaaaaaa agatgacctt cgcgcaagga aaagaagtac tcgacaatgt ctccatgatc 2662441 acaacagtga gcgaatttat taaacaaacc gtcattgaac gtttccctga agccgaggac 2662501 atcacaaaag ttgtgtattc cggcgttgat ttaaactctt atccgcccgt ctggacgatg 2662561 aaaggctcgg ctgtcagaaa aacataccgg aaaaaatacg gtattgaaga taaaaaagtt 2662621 attttattcg ccggccgctt aagcccgaca aaagggcctc accttctcat tcacagcatg 2662681 agacggattt tgcagcagca ccctgatgct gtactggtca tagcaggcgg gaagtggttc 2662741 agcgatgaca gcgaaaacca atatgtcacc tatctgcgca cgctggcgct gccatacaga 2662801 gaccacataa tctttacaaa attcattccc gcagacgata tcccaaacct ttttctgatg 2662861 gcagatgtat ttgtgtgcag ctctcagtgg aacgaacccc tcgcccgtgt gaattatgaa 2662921 gcaatggcgg ccggcacgcc cttaattacc acaaaccggg gcggaaacgg tgaagtcgta 2662981 aaacacgaag tcaccggcct tgtcatcgat agctacaaca aaccttcttc atttgcaaaa 2663041 gcaattgaca gagcctttac agatcaagaa ttaatgaaca aaatgacaaa aaacgcccga 2663101 aagcatgtag aagctttatt tacctttacc catgctgcca aaaggctcaa tactgtttac 2663161 caatccgttc tgaccccgaa aaacaaacaa tttccgccgc cttttctgac gcaaaatttt 2663221 gatttatcat ctatcaatca gctttttgtg aaagcaaaaa cataaaacct acagctcgtg 2663281 ttgcaaaacg ggctgttttt tcgctacaga gaacttaaaa aaaggcataa atgtgacttt 2663341 atgccttgcg ctttacagtt tgagaaaacc atggagctgg tttagattca cttggaagaa 2663401 tgatgatttc cactttagct tcttccgcta agtctggttc ttcatcttca tcctcttctt 2663461 catatggggg cgctgagcgt ttcgaatcac gctcctcctc aggctccaga gtggtttcga 2663521 attttgtttc ttcttcatca tcgacgattt tgcgatctgt ttccttttcc ttcgtttctt 2663581 tttgatattc tttcggtgca ttgatgtgag ggagctctcg aatgctgccc acatctaaat 2663641 gcttctcctc ttcttccttc tcagctgaga ttgagtcatg agcctgccat cccatcggtc 2663701 caggcggtgt aaatacgaat tggtcgagat ccagtttaga aatagaggct ttttgtctcg 2663761 atgacctcat gtcaattcgc ctcccgatac gcttttatct ttttatacag ttccggcagt 2663821 ttatccaaaa acgaatcttt agattcttca acagaaatca tgttttgcag cgcccagtta 2663881 tacttctcat ctgaccacgt tttcttttgc ttcaaataat atttgtgccc gattgcacag 2663941 aacaaatgcg gaaacgcgag atcaatccaa agtacctcgt actgtttttc tgtgagcgga 2664001 tacactgcgt cgtaggccgc aagcagtgca accatgaaat cagtatccca tacagaaagc 2664061 ttaaccatca ctttattcag cagaatacga aggtctcttg acggcaaatc gtaggtaatc 2664121 gagtgaagct cctttaaaaa aggctcccct tcgatctcag tcaaacgtgc caatgtaaaa 2664181 tcctgaaaac agaatccgcc atgctcgagt gtctcttttg tccaggtttc gtattctgag 2664241 tcatcaagcg ctctgagagc ttcttttcct cttgccagca ttttatcagc atgttttaag 2664301 aaagtttgcg aaaatacgtc atcaggatag gatgctgcga tctgcatatt cccttcaagt 2664361 tcctgcagct tccaacggta caatttgtgc cattttccca gcctgcttct cttcttgctt 2664421 tcatctgtgc aaacatatcc ttttgaggca tgatgaaaat ggccggcaaa tgacatgact 2664481 tttttcattt gctctgcatc atagtaaatc atttcttttc ctgtcacttt gtcatataaa 2664541 ctgtaagaaa cctgatccgt gcccaagcag ctaccgccat tttttgtttg atgaatcggc 2664601 gctatcggca gccctttctc ttgtaaatgg gcgtgtgcct gagtgataaa aagcatccgc 2664661 tccggtttca tttgcgcttc ttttagcagc tttgggccat gatcagtttc gacttcccag 2664721 attttgcgcc cgcttttgtt cgatttcagc gccacatggt cgatatgaaa cggataataa 2664781 ctgagaattt cggacacaat ctgttcttca tgctcttttt ggtacactct gttcacccct 2664841 tctatctgtt cttttcatag acgctgagca gattttcagc caccctctgc cagccaaaat 2664901 tgctttctgc ctcacggcgg ctgtatttcc caagccgttc ccgcttttcc gagctgctca 2664961 gcaaatcatt gatacgttcg gcatattgtt taggattttc aaagtcatga atgatgtagc 2665021 cgtttttccc ttcctctatg acctctggat tgcctccccg attgcttgta ataataggaa 2665081 gtcccgcagc catcgcttca taatgcaccc ttgctaaagg ctcctgccat tgcgaagagc 2665141 atacaaatac atctgacatg gtataaaggc gcggaatgtc ctttggcttc acaaattgaa 2665201 taaatgtgac atgatccttt tgcatcgcac caagggtatg aagatgtttg acatagttat 2665261 ttaattcatt atctccgaac cattttgacc cgataaacac catcatgaca tcggggtgct 2665321 cctcaatgat gtccggcaaa gcctgcaata atatgtgcgg gcctttgact ttgctaagcc 2665381 ggccgacaaa caagacgatt tttttgccgt gaagccccag ctcgcttcgc atctcttcgc 2665441 gagctcgctg cccttcattc gtccagcgag ggtggtacgt ttttaaatcc acaccagaat 2665501 acaccgtttt tgtttttgat cgtgctgacg gaaaacggct tgtgatcgtc tgtccgatat 2665561 aatcgctgac cgtaacaatc tgcgctacgg agtcgatgca aatctcgcct tccgcctggc 2665621 tgattttatc gtaagcgaac atttcattgt gaacgcttaa aataaaaaca gcatccggcg 2665681 cctgtttctt caatttcgga acccagcttg ggcgattaca aacatgcaca agatcaaaac 2665741 ggctcttttt cagctctgct ccaacggctt cttcataacg gtcttcatcc aaatgcacat 2665801 aatggacacc gtctaccttc tctctatcag cgagattcgg atctttaata gaaaacacag 2665861 tcacctcatg tttttttgca attaaagggg caaccgcttc gaggtagatt tgaatggcgc 2665921 ctcctcgaac cgatgggaca ggaagcttct ctgtggcgat cagtgctatt ttcatacata 2665981 gcctccattc ctgcatgatt tttaactagt tagaatcatg atacggctga acaaccaact 2666041 tgtgcggaat gggactgccc taaaaacaaa acgggtaaac aaccagattc atctattaaa 2666101 tatagtcaaa taactcaatc attttttcct tttgattcat aaggtaggag taaaacaggt 2666161 aaggatgtgt cctttaatgg cagaaaacca tgaagtcatt gaggagggga attcatcaga 2666221 gcttccttta tcagcagaag atgcaaaaaa attaacggag ctggctgaaa atgtgcttca 2666281 aggatgggat gtgcaggctg aaaaaataga cgtcattcag ggaaaccaga tggcgcttgt 2666341 ctggaaggtc cacacagact ccggcgcggt ttgtctaaaa cgaatacaca ggccagaaaa 2666401 gaaagcgttg ttttccattt tcgcgcagga ctatttagca aaaaaaggca tgaatgttcc 2666461 tggcatactc ccaaacaaaa aaggcagcct atattctaag cacggctcat ttctatttgt 2666521 cgtatatgac tggatcgaag gaagaccgtt tgagctgact gtaaagcagg acttggagtt 2666581 tatcatgaaa ggccttgctg attttcatac agcttccgtc ggatatcagc cgccaaatgg 2666641 cgttcccata tttaccaaat taggtcgctg gccgaatcac tacacgaaac gatgcaaaca 2666701 gatggaaacg tggaagctga tggcggaggc ggaaaaagaa gatcctttct cacagcttta 2666761 tcttcaggag atagatggct ttattgaaga cgggctgcgc atcaaagacc ggcttttgca 2666821 atcgacctat gttccatgga ctgaacagct gaaaaaaagc cctaaccttt gccaccagga 2666881 ttacggaacc gggaatacac tcttaggaga aaatgaacag atttgggtca tcgacttaga 2666941 taccgtatca tttgatctgc ctattcgcga tttgcgcaaa atgattattc cgcttttgga 2667001 tacgacgggt gtttgggatg acgaaacatt taatgtcatg ctgaacgcat acgaatccag 2667061 agccccatta actgaagaac aaaaacaagt catgtttatt gatatgctgt ttccttacga 2667121 gctttacgat gtcattcgcg aaaaatacgt ccgcaagtct gctttaccga aggaagaatt 2667181 agaatcagct tttgaatatg aacgcattaa agcaaacgca ttgcggcagc ttatttaaga 2667241 ccatcatttc ccccgcatat cgggggtttg atatttataa gataaagggt aattaaatac 2667301 atgcggaggt tgcaaatatg aaaaagattg tcggcgcttt agccgttttt gtgattacat 2667361 atgcgctgtt ttcagccgca ggctacctgt ttcctgtgga ccaagaatgg tacaattcat 2667421 tgaaaaaacc ggactggacg ccaagcggaa ctgcgatcgg catcatttgg gccatcctgt 2667481 ttgccctgat ctccctttca gcagccattg tatatgctgc gttttcattt aaaggtgcga 2667541 aaagcttttg gtttacactt ttgataaatt acgtgctcaa tcaagccttc agctatttcc 2667601 agtttacgca aaaaaatctg ctggctgcat cgcttgactg cctgcttgtc gccatcacag 2667661 caatcgtatt actgatcatt gccaaaaaat acagcagagc cgcaagctat cttcttttgc 2667721 cttatttttt atggagtgca tttgcgacgt tcttatcctt tacaatcaat tcaatgaatc 2667781 tgtgaacaaa aaaagccgct tatacagcgg ctttttcaca tcatcggctt gatgccccaa 2667841 atgtccttcg catattcccg gatcgtgcgg tcgctggaga aatatccaga atgagcaatg 2667901 tttacaatcg aatgctcaga ccatttcctt cgctctcgat aatcagcttg aattcgctcc 2667961 tgtgcatctg catatgagct gaaatccttc agcacaaaat actcatcatt atgcggaagc 2668021 agcgagtcaa agatcgattc aaattcatct gcctctcctt caaaaaaacc attgatcaac 2668081 tgatccgcta cctgcctgat tctcctgtca tgctgataat attccctcga cctatagccg 2668141 ccgttttcct gatacgatag aacctcatcc gcctttaagc cgaacgtgta aatacagtca 2668201 gggcccaccc gctcaaggat ctcgatattt gcgccgtcat gcgtgccgat cgtcaaagcc 2668261 ccgttcatca taaacttcat attccctgta ccagacgctt ccttgcttgc ggttgaaatt 2668321 tgctcactta cgtctgatgc cggaaaaatt cgctcagcca tagaaactct ataattttct 2668381 aaaaaaacaa ctttgatcag ctgtttgacc gccggatcat aattgacttt ttctgcgaca 2668441 gaatggatca gcttaatgat tttcttggca taataatagc ttggtgaagc ctttgccccg 2668501 aaaataaagg tttgcgggta gattgaaaac cccgaatcct ccttgaggcg gttatacaaa 2668561 tacataatgt gaagaacatt cagcagctgc cgtttatatg catgaagccg tttcacctgt 2668621 acgtcgaata tgctctcagg gttcacaacc accccggccg tgcaaaaaat caaatcggca 2668681 agctcttgtt ttttcttgct tttgttgttt tgaaactgtt caataaatgc aggatcagtg 2668741 gcgtacggtt ctaaacggat cagtgattcc ggctgcttga cccattcatc gccgatcgcc 2668801 tctgtaatga tggcagacaa gcctggattc gcttttaaca gccagcgcct gtgggcaatt 2668861 ccattcgtct tattgttaaa acgattcgga aacagcaagt gaaagtcgcg catctccctt 2668921 tcctttaata tatcggaatg tatttttgca acgccattta cactgtagct gcctactatg 2668981 gccagatgag ccattttgac aacaccatgc gctgtaatcg ccatgttctc tatccttttc 2669041 cagtctccag gatacttttc ccaaactgca cggcaaaacc tctcattgat ctcttcaata 2669101 atcatgtaca ttcgcgggag cagcggctta aacaaatgaa tcggccattt ctcgagcgct 2669161 tctgacaatg ttgtatgatt tgtataagaa atcgtatgta cagtgatatg ccaagcttct 2669221 tcccagctca tgttctcttc atcgagcaaa atccgcatta gctcaggcac cgcaagcgca 2669281 gggtgagtgt cattaatatg aatgctcact tttttatgca ggccggataa agatttatgt 2669341 gttttacggt aattgttcac aatgcttttt aagcttgcgc atactaaaaa atactgctgc 2669401 ttcagccgta aaattttccc ctcatcatgg gtgtcatcgg gatataagaa ttcagaaacc 2669461 gcttctgttt ctcgcttata agacaaaata ttaccgccgt gataatgggc atagggctcg 2669521 gcgttccaaa gccttaacgt gttgacagtg cccgtttcat agccgatgat cgggatatca 2669581 taaggaacag cggtaacaat tgtcgcttgt tcatggcgaa aatgcaggcg cccgcttttt 2669641 tctgtcatat ggacttcgcc ccaaaacggc acgtccactg cttgatccgc attccttact 2669701 tcccatacgt tcccgttttt cagccattgc tcaggcagct ccacctgatg tccgtctaca 2669761 attttttgct caaacaaacc atgcttataa cgtatgccca tgccgtgccc aggcaggttc 2669821 aacgaagcaa gcgaatctaa aaagcaagcg gccaagcgcc caagtccgcc attgccgaga 2669881 cctgcatcgt tctctatctg aaggatctcc tctaaattga tgccgatttc ctttaaacca 2669941 gcttctacaa catcacgaac accaagattc attaagtttt gctcaaggag ctgaccgagc 2670001 agaaattcga ttgataaata atatgtctgc ttcccggaat ttgatctgct tttttcattc 2670061 gtttcgatcc aatcagcgct gatatactct ctgaccatat tgcccaacgt tttatattga 2670121 tccagcttgg cagaatcttt aaagcttttt ccgcacgtca tttccagacg ctttaaaaat 2670181 aagtctgcaa agcgttcttt actcgagaac atcccgtcca ctccttgtca cctgctcgaa 2670241 aatacgctga tactctttag ccgacttccc ccagctgtaa tctgcattca tagcggtctt 2670301 cacgatgctc ttccatacat cctgttggca ataaaacgac agcgcccttt ctatcgtaaa 2670361 tttcagatca tgcgcattaa aggcggaaaa cgtaaagcca ttgcccgttc cctcttcctc 2670421 ctgataggca cggacagtgt cgtaaagacc gcccgtttcc ctgacaatcg gaatggcgcc 2670481 atattgaaga gcaatgagct gccccaaacc gcacggctca aatttcgacg gcatcaaaaa 2670541 catatcagag cccgcataaa tttgatgggc tagcggctca tcaaacccga tataagcccg 2670601 gcacttctca tgaaaagcaa attctgcata ccggaaataa tcttcaaatt cacgttctcc 2670661 tgtgcctagc acaaccagct gtatgtcttg ctcctcaaga agttcgtgca taattctgcg 2670721 gacaagatca agcccctttt gtttagtgag ccttgtcacc atactgatca gcggaatatc 2670781 gtttttctct ggaagcccca tccgctgctg aagcttcgtt ttgttttcca gcttgcatgc 2670841 aagatcccct gaatcgtatt gcgcctctat ataagggtcg cttttcggct gatagaacgt 2670901 atcatcaatg ccatttaata tgccggttac atcatcttcc ctatattgca aaacctgttc 2670961 caactgctca ccataatacg gcgtcatgat ttcatttctg taagtggggc tcacagttgt 2671021 cacatgatca gccgcaatga tgcccgcttt cataaaatta acaaatccgt tgcattctaa 2671081 cctttcataa tgaaaatgat ccatctcaag acccagcaag tcatgtgtga catcaggagg 2671141 gaatatgcct tgaaactgca ggttgtggat cgtgagcacg cttttcatcc gttcataaaa 2671201 aggatgtttt ctgtactcct ctttcagcaa ataattgacc atcgctgtat gccaatcgtg 2671261 agtatgaaca atatcggctt gaacattcac aactttggca gcctccagca cagctcttga 2671321 aaaaaaggca aaccgctcac cgtcatcata atgcccgtac aacgaatccc tgttgaaata 2671381 gtactcattg tcgatgaagt aataattcac atcattctct gccatatgtt caattccgca 2671441 atattgctgc cgccagccga cagctacggt acactcagcc tgttttttca tacgcttttt 2671501 ccacggttca ggtatttggc tgtacttcgg cagcatcaca gctacctcat tgcctaatcg 2671561 cgcaagcgcc tttggcagag cacctgctac atcggcaaga cctcctgatt tcacaaatgg 2671621 ggtgcattct gacacagcaa ataatatctt caagaattca tcagctctcc ttgcaccaaa 2671681 ccttttctta atacaagcgg ctgctcagct gttcctgcag cttccgtcgc cttgccgatt 2671741 ttaacatcct tatccgaaat gacctgctca agaagacaat cctctccaat ctgcgttttt 2671801 tgcataataa tgcagttttt cagcttcgta ccctttccga catggaccgc cctgaacaaa 2671861 atgcagtttt caacctctcc ttcaagcaca cagccgtttg ccaccaaaga atttttgaca 2671921 gtgctgtgct ttccgtattt cgtaggcggc tcatccttca cttttgtata gatcggctgc 2671981 tgcggcaaaa acacctgctg ccaaaaacga ggctgaatga gctccatact gtgggtataa 2672041 tatttttcca ccgaatcaat gacagcggca taacctgaat attcataagg gcaaatggtc 2672101 agggcggaag attccttttc aacagcctcc tgaatggttt tatagccttt ttcgctatgt 2672161 ccgtagatca gatcctttaa aagcgttgtt gacatgatat agatttgcag cgactggccg 2672221 tcctgaaata cctcggtgac gtcgcagcca acctcctgat ggcgtttcag cacatattga 2672281 aattgaatgt tgcatacggt atggctgttg gagattacag catattgctg agtgcttctg 2672341 tggaagtaat ctagatggtc cgaaaactgg cgaaaggaac cgaattcatc gtattcgtga 2672401 tgaagatggg gagacgggaa aaaaaagagg ccgtcctttt tccggtgcaa atcccattcc 2672461 ttacccgccc caaggtgatc catgagcgaa cggtaacgat acttcggaaa aattgcaaca 2672521 ctcctaatat ccgcattcac catgttggaa agcataaaat caatcagtcg gtacctgccg 2672581 gcaaaaggga tcgccccgag cgaccgctgt gctgttaaat cctgaagaga atgcttatat 2672641 gtggtttcat ctataacacc taacatttga ttattgaaca ctgactctgc cccctcttca 2672701 gtaattaaat caattctttt tctacaaatt cctctgaaac gagcagcacc tcttcaatgt 2672761 ctttttcgga gcgaatcact gcgccatccg gcagcaccat cccattagga acgatggcat 2672821 tttcaatgac tacatgctcc ccaatcgtca catccggcat tatgacggat gatgtaacag 2672881 tcgtatgctt accaacagtc acaccttgaa aaagaacgga gtgagacaca tttccatata 2672941 caacacaacc ttcgttcaca agcgaatctt gaacctgcgc atcagatgaa ataaattgcg 2673001 gaggctgatt tggattgacg gagtaaattt tccatttgcg ttcaaacagc ttcagctccg 2673061 agtcctcttt taacaaatcc atattggctt cccacaagct ctgcaccgtt ccgacatcct 2673121 tccaatatcc cttgaacgga taagcagaaa gcttcttttt ctcttccaaa agcagtggaa 2673181 taatgtcttt gccgaagtcg tggctagaat aagggttttg atcgtccatc tcaagatact 2673241 gtttcaaaag cggccaattg aatatataaa ttcccattga ggcaagattg ctcttaggga 2673301 atttgggctt ttcatcaaaa tgtgtgatcg tcccatctgg attggccttc atgatgccga 2673361 accggcttgc ttcctcccag cccacttcga tgacagagat ggtcacatct gctttctttt 2673421 caatgtgata atcaagcatt ttgccgtagt ccattttgta tatgtgatct cctgataaaa 2673481 tcagtacata ctcaggatca tactgattca aataattgag attttcataa atggagcttg 2673541 ccgtcccttt ataccatttg acttctgatg actcggcata agggggtaaa accgtcacgc 2673601 cgccattata tctatccagg tcccatgcac tgccgatccc aatataggaa ttcagctcga 2673661 gcggctgata ttgcgttaaa atcccgactg tgtctatgcc tgaattagaa cagttgctta 2673721 gggtaaaatc aataatcctg tattttcccc cgaaagatac agccggtttg gccatatttt 2673781 ttgttaatcc gctgagacgg ctgcccttcc cgccggcaag gagcatggct acacattgtt 2673841 ttttcatctt tttatctctc ctcttttttt aaccgcccgt aaaatcgaga tgccgtaagg 2673901 ggggatggtc atcgtgatat aacacggttt atgatgaagt gctccctttt tagccgataa 2673961 cggctttttg ttgatttgcc ctgagcctcc atatgtttca ctgtcactgt taagcacttc 2674021 aatgtattga gtaaaaaaag gaactccaac atcatattga tgatagacca cgggtgtaaa 2674081 attacaaatg atgacaagcg cctcaccgtg cttttggcca taacgaataa aagaaaagat 2674141 tgattgttcg tcattatgga catcaatcca ttcaaacgat tgtgcacgat ggtcatgctc 2674201 ataaaggatt ttgctttttt ggtaaaagcg gagaagatct tgcgtaaaaa cgctggcttt 2674261 ctgatgcatg gggaaggagt ccaaaaacca atcaagctgt tctgtatctt tccattcatc 2674321 aaattgagca aactctgatc ccataaagat caatttcttt ccgggatgca ctgtcatata 2674381 gcccagcaaa agccgatact gggcaaattt ctgccagtag tcgccaggca ttttattgag 2674441 aagtgatttt tttccgtata cgacttcatc atgagaaaac ggcaatacaa aatgttcact 2674501 aaacgcatat agtaatgaaa aagagataag ctgatgacaa tgccgccttt cttcgggcgg 2674561 cgtctccatg tatttcagta cgtcattcat ccatcccata ttccatttat aatgaaaacc 2674621 aagcccccct tcctcaacgg cacctgtcac ttgaggccat tctgtagaat cttctgcaat 2674681 catcatcaca tggggatatg cctctctcat ggtttgattg agttttttta aaaaatcaac 2674741 agcatatgga ttcgtgtggc gttcatcctg atttggccaa tacaagatat tagccactgc 2674801 atcaacccta aatccatcta tatgatagaa ttccgcccag tacaacgcat tcgaaattaa 2674861 aaaactatga acttccggtt tccccaggtc aaagtttgcc gtgccccata accagttctc 2674921 ccgatcacgt tcttctttgt attcataaag cggttctcca tcaaacatat aaaggccatg 2674981 tgcatcttta caaaaatgtc cggggaccca atccaaaatg actccgatat tttgttgatg 2675041 acattcatcc acaaacttca tcagatcatg cggcgggcca aacctgcttg tcgggctgta 2675101 ataccccgtt ccttggtacc cccatgaacg atcatatgga tgctcataca cgggaagcag 2675161 ttcaatatgg gtaaacccat gcttcttgat ataagggata agcgtctgac ttaattcttt 2675221 ataggaataa tgcctgccat cagaatgctt cttccaagac ccaagatgca gttcataaat 2675281 gaaaacaggt ttttcataca gcgtcttagc cttctgtttc ttttgccatt tttgatcttg 2675341 ccagctgtat ccttccaaat cgtaagtaag tgacgctgtg tttggtctga cttctgaata 2675401 aatagcgtat ggatctgcct tcagcctgat ctcaccgtta ttcgtcacaa tttcgtattt 2675461 atatcgttcc ttttctccta tacctggaat aaataacgtc caaatgccat tatcattcac 2675521 tctgtgcatc acatgctctt ctccagacca gctgttaaaa tctccagcca ctcgtacttc 2675581 cgacgcatga ggcgcccaca cacagaattc atatccgctt ttgccattca gctcgcggta 2675641 atgcgagcca aacagctgat agcttttaaa cagactgcct tcgtgaaaaa gataaacatc 2675701 atgtgctgtc gggctggcag cggccatgta atcatccttt ctgacatcat agttttcatt 2675761 tatagtattt attcgaagaa ataaaaaaaa gccctttcct gaaagcgctt atacttatag 2675821 acaattaact tcattttctg aagaaaaacg aaatatatgg agatttttgt agtctgtttt 2675881 taaaataaag aacaaaatct aagacatatc atgatttata aaaacaaaaa aaccttgcag 2675941 gatatgcaag gcttctggat gacccgtacg ggattcgaac ccgtgttacc gccgtgaaag 2676001 ggcggtgtct taaccgcttg accaacgggc cgataattat gatatctgta atcatatggc 2676061 ggagaaggag ggatttgaac cctcgcgccg cttacacgac ctacaccctt agcaggggcg 2676121 cctcttcagc cacttgagta cttctccatt tggctccaca ggcaggattc gaacctgcga 2676181 ccgatcggtt aacagccgat agctctacca ctgagctact gtggaacaaa agtcatggtg 2676241 ggcctgaatg gactcgaacc atcgacctca cgcttatcag gcgtgcgctc taaccagctg 2676301 agctacaggc ccatgacgat atagaaatgg agcgggtgat gggaatcgaa cccacgacat 2676361 cagcttggaa ggctgaggtt ttaccactaa actacacccg caatttttat ttggggcgat 2676421 tgatgggaat cgaacccacg aatgccagag ccacaatctg gtgcgttaac cacttcgcca 2676481 caaccgccaa agcatattga taaatggtgg ctcgggacgg aatcgaaccg ccgacacacg 2676541 gattttcagt ccgttgctct accaactgag ctaccgagcc taagtattta aatggcggtc 2676601 cggacgggac tcgaacccgc gacctcctgc gtgacaggca ggcattctaa ccaactgaac 2676661 taccggacca ttttaaaatt tggttgcggg ggcaggattt gaacctgcga ccttcgggtt 2676721 atgagcccga cgagctaccg aactgctcca ccccgcgatg attaggaata tgtatggcgg 2676781 aggaagaggg attcgaaccc ccgcgggctt tgacacccct gtcggttttc aagaccgatc 2676841 ccttcagcca gacttgggta ttcctccgta tagtggtgga ccttgtagga ctcgaaccta 2676901 cgaccggacg gttatgagcc gtctgctcta accaactgag ctaaaggtcc attggtagcg 2676961 gcggagggga tcgaaccccc gacctcacgg gtatgaaccg tacgctctag ccagctgagc 2677021 tacaccgcca aatatttttg aaatcaagtg gagcctagcg ggatcgaacc gctgacctcc 2677081 tgcgtgcaaa gcaggcgctc tcccagctga gctaaggccc caagaatggt cgggaagaca 2677141 ggattcgaac ctgcgacccc atggtcccaa accatgtgct ctaccaagct gagctacttc 2677201 ccgatttcat atagatcatg gcgcgcccga gaggagtcga acccctaacc ttttgatccg 2677261 tagtcaaacg ctctatccaa ttgagctacg ggcgcaaaac ttaatgccga gggccggact 2677321 tgaaccggca cggtagtcac ctaccgcagg attttaagtc ctgtgtgtct gccaattcca 2677381 ccaccccggc gtggatggta tagttggagc ggaagacggg attcgaaccc gcgaccccca 2677441 ccttggcaag gtggtgttct accactgaac tacttccgca gaaatggtgc ggatgaaggg 2677501 acttgaaccc ccacgtctgt aaagacacta gagcctgatt ctagcgcgtc tgccaattcc 2677561 gccacatccg caacatgtaa atggtgagcc atgaaggact cgaaccttcg accctctgat 2677621 taaaagtcag atgctctacc aactgagcta atggctcttc ttacaataga cttgaatatt 2677681 atatcatata aaagtggtgc cggcaagagg acttgaaccc ccaacctact gattacaagt 2677741 cagttgctct accaattgag ctacaccggc atatatgtaa aaccgatatg tataatgaaa 2677801 aatggtggag gatgacgggc tcgaaccgcc gaccctctgc ttgtaaggca gatgctctcc 2677861 cagctgagct aatcctccat acttgcacta acgtgcaatt gcttggcggc gtcctactct 2677921 cacaggggga aacccccgac taccatcggc gctgaagagc ttaacttccg tgttcggtat 2677981 gggaacgggt gtgacctctt cgctatcgcc accaaacaaa ttgagagtgt tctctcaaaa 2678041 ctagataaca ggtgtgacat cattcaaaaa tatggttaag tcctcgatcg attagtatct 2678101 gtcagctcca tgtgttgcca cacttccacc tcagacctat caacctgatc atctttcagg 2678161 gatcttactt ccttgcggaa tgggaaatct catcttgagg ggggcttcat gcttagatgc 2678221 tttcagcact tatcccgtcc gcacatagct acccagcgat gcccttggca gaacaactgg 2678281 tacaccagcg gtgcgtccat cccggtcctc tcgtactaag gacagctcct ctcaaatttc 2678341 ctgcgcccgc gacggatagg gaccgaactg tctcacgacg ttctgaaccc agctcgcgta 2678401 ccgctttaat gggcgaacag cccaaccctt gggaccgact acagccccag gatgcgatga 2678461 gccgacatcg aggtgccaaa cctccccgtc gatgtggact cttgggggag ataagcctgt 2678521 tatccccggg gtagctttta tccgttgagc gatggccctt ccatgcggaa ccaccggatc 2678581 actaagcccg actttcgtcc ctgctcgact tgtaggtctc gcagtcaagc tcccttgtgc 2678641 ctttacactc tgcgaatgat ttccaaccat tctgagggaa cctttgggcg cctccgttac 2678701 cttttaggag gcgaccgccc cagtcaaact gcccacctga cactgtctcc ccgcccgata 2678761 agggcggcgg gttagaaggt caatacagcc agggtagtat cccaccgatg cctccaccga 2678821 agctggcgct ccggtttcca aggctcctac ctatcctgta caagctgtac caacattcaa 2678881 tatcaggctg cagtaaagct ccacggggtc tttccgtcct gtcgcgggta acctgcatct 2678941 tcacaggtac tataatttca ccgagtctct cgttgagaca gtgcccagat cgttgcgcct 2679001 ttcgtgcggg tcggaactta cccgacaagg aatttcgcta ccttaggacc gttatagtta 2679061 cggccgccgt ttactggggc ttcaattcgc accttcgctt acgctaagcg ctcctcttaa 2679121 ccttccagca ccgggcaggc gtcagcccct atacttcgcc ttacggcttc gcagagacct 2679181 gtgtttttgc taaacagtcg cctgggccta ttcactgcgg ctctctcggg cttgcaccct 2679241 aacagagcac cccttctccc gaagttacgg ggtcattttg ccgagttcct taacgagagt 2679301 tctctcgatc accttaggat tctctcctcg cctacctgtg tcggtttgcg gtacgggcac 2679361 ctctcacctc gctagaggct tttcttggca gtgtggaatc aggaacttcg ctactatatt 2679421 tcgctcgcca tcacagctca gccttatggg aaacggattt gcctatttcc cagcctaact 2679481 gcttggacgc ggatatccaa taccgcgctt accctatcct cctgcgtccc cccattgctc 2679541 aaatggtgag gaggtggtac aggaatatca acctgttgtc catcgcctac gcctttcggc 2679601 ctcggcttag gtcccgacta accctgagcg gacgagcctt cctcaggaaa ccttaggcat 2679661 tcggtggagg ggattctcac ccctctttcg ctactcatac cggcattctc acttctaagc 2679721 gctccaccag tccttccggt ctggcttcac agcccttaga acgctctcct accactgttc 2679781 gaagaacagt ccgcagcttc ggtgatacgt ttagccccgg tacattttcg gcgcagagtc 2679841 actcgaccag tgagctatta cgcactcttt aaatggtggc tgcttctaag ccaacatcct 2679901 ggttgtctaa gcaactccac atccttttcc acttaacgta tactttggga ccttagctgg 2679961 cggtctgggc tgtttccctt tcgactacgg atcttatcac tcgcagtctg actcccaagg 2680021 ataagtcatt ggcattcgga gtttgactga attcggtaac ccggtagggg cccctagtcc 2680081 aatcagtgct ctacctccaa gactcttacc ttgaggctag ccctaaagct atttcggaga 2680141 gaaccagcta tctccaggtt cgattggcat ttcaccccta cccacacctc atccccgcac 2680201 ttttcaacgt gcgtgggttc gggcctccat tcagtgttac ctgaacttca ccctggacat 2680261 gggtagatca cctggtttcg ggtctacgac cacgtactca tgcgccctat tcagactcgc 2680321 tttcgctgcg gctccgcatc ttctgcttaa ccttgcacgg gatcgtaact cgccggttca 2680381 ttctacaaaa ggcacgccat cacccgttaa cgggctctga ctacttgtag gcacacggtt 2680441 tcaggatctc tttcactccc cttccggggt gcttttcacc tttccctcac ggtactggtt 2680501 cactatcggt cactagggag tatttagcct tgggagatgg tcctcccgga ttccgacgga 2680561 atttcacgtg ttccgccgta ctcaggatcc actcaggaga gaacgaagtt ttgactacag 2680621 ggctgttacc tcctatggcg ggcctttcca gacctcttca tctacctcgt tcttttgtaa 2680681 ctccgtacag agtgtcctac aaccccaaga ggcaagcctc ttggtttggg ctgatcccgt 2680741 ttcgctcgcc gctactcagg gaatcgcatt tgctttctct tcctccgggt acttagatgt 2680801 ttcagttccc cgggtctgcc ttctcatatc ctatgaattc agatatggat accactccat 2680861 tacgagtggt gggtttcccc attcggaaat ctccggatca aagcttgctt acagctcccc 2680921 gaagcatatc ggtgttcgtc ccgtccttca tcggctccta gtgccaaggc atccaccgtg 2680981 cgccctttct aacttaaccg ttaaaaagaa tcactatgtg atatcttgtg ttactaattg 2681041 aatgtgatgt ctactgttat ctagttttca aagaacacgt ttcgaaggaa tgatccttca 2681101 aaactaaaca agacagggaa cgttctgttt ataagacctt gggtcttata ttccgtataa 2681161 tatccttaga aaggaggtga tccagccgca ccttccgata cggctacctt gttacgactt 2681221 caccccaatc atctgtccca ccttcggcgg ctggctccta aaaggttacc tcaccgactt 2681281 cgggtgttac aaactctcgt ggtgtgacgg gcggtgtgta caaggcccgg gaacgtattc 2681341 accgcggcat gctgatccgc gattactagc gattccagct tcacgcagtc gagttgcaga 2681401 ctgcgatccg aactgagaac agatttgtgg gattggctta acctcgcggt ttcgctgccc 2681461 tttgttctgt ccattgtagc acgtgtgtag cccaggtcat aaggggcatg atgatttgac 2681521 gtcatcccca ccttcctccg gtttgtcacc ggcagtcacc ttagagtgcc caactgaatg 2681581 ctggcaacta agatcaaggg ttgcgctcgt tgcgggactt aacccaacat ctcacgacac 2681641 gagctgacga caaccatgca ccacctgtca ctctgccccc gaaggggacg tcctatctct 2681701 aggattgtca gaggatgtca agacctggta aggttcttcg cgttgcttcg aattaaacca 2681761 catgctccac cgcttgtgcg ggcccccgtc aattcctttg agtttcagtc ttgcgaccgt 2681821 actccccagg cggagtgctt aatgcgttag ctgcagcact aaggggcgga aaccccctaa 2681881 cacttagcac tcatcgttta cggcgtggac taccagggta tctaatcctg ttcgctcccc 2681941 acgctttcgc tcctcagcgt cagttacaga ccagagagtc gccttcgcca ctggtgttcc 2682001 tccacatctc tacgcatttc accgctacac gtggaattcc actctcctct tctgcactca 2682061 agttccccag tttccaatga ccctccccgg ttgagccggg ggctttcaca tcagacttaa 2682121 gaaaccgcct gcgagccctt tacgcccaat aattccggaa aacgcttgcc acctacgtat 2682181 taccgcggct gctggcacgt agttagccgt ggctttctgg ttaggtaccg tcaaggtacc 2682241 gccctgttcg aacggtactt gttcttccct aacaacagag ctttacgatc cgaaaacctt 2682301 catcactcac gcggcgttgc tccgtcagac tttcgtccat tgcggaagat tccctactgc 2682361 tgcctcccgt aggagtctgg gccgtgtctc agtcccagtg tggccgatca ccctctcagg 2682421 tcggctacgc atcgttgcct tggtgagccg ttacctcacc aactagctaa tgcgccgcgg 2682481 gtccatctgt aagtggtagc cgaagccacc ttttatgttt gaaccatgcg gttcaaacaa 2682541 ccatccggta ttagccccgg tttcccggag ttatcccagt cttacaggca ggttacccac 2682601 gtgttactca cccgtccgcc gctaacatca gggagcaagc tcccacctgt ccgctcgact 2682661 tgcatgtatt aggcacgccg ccagcgttcg tcctgagcca ggatcaaact ctccgataaa 2682721 tggatcacag gttaagttca ccgcatcctg cggcgacacc tgtgtgacct gcgtcgtgca 2682781 ggccctagtt tgactgacta cgcacatcgc agtgcgattt ttaaaaactg aattaacagg 2682841 tacgttttgt cttgtttagt tttcaaagat catttcgtta cttctcaatg aagcagcttt 2682901 actaatataa cattcagctt cttttttgtc aacaactttt ttcaagttgt tttgaagcat 2682961 ctagtttgtg tccgctgtgc atcagcgacg tttaataata taacacctgt atttatttat 2683021 tgcaatagtt ttttaaaaaa aatctataaa acaaataaac tataatcctc gccatgattt 2683081 ctaaagcgtg tgtatcatat aagtttctta aaagaacata tacatcagtc atgtgatctt 2683141 gttgtttttt tcgttttctt gtatagtaga aacgaactaa atactgatga ccacaagggg 2683201 agcattaaag ctgagagtga gcggtttcgt tctgaccctt tgaacctgtt agttaacgct 2683261 ggcgtaggga tgtggcaaag tcaaatgaat tgcagatcgt aaagcagtgc gtggaacttt 2683321 tctcatcctt ccgcgtgctg cttttttgtt gtccttttgg ttgtctgtca atggaaggag 2683381 atagatatga atcaatctaa gcaactggtt cgccttattg aaattgccat tatgacagcg 2683441 gcagccgtta ttttagacat tgtctcagga atgtttctta gcatgcctca aggaggctcg 2683501 gtctccatca tgatgattcc gatcttttta atttcgtttc gctggggtgt caaagcaggt 2683561 cttactacag gtttgttgac aggtctagta caaatagcaa tcggaaactt gtttgctcaa 2683621 catcctgtac agctattgtt agattacatt gtcgctttcg cagcaatcgg cataagcggc 2683681 tgtttcgctt cttctgtccg taaagccgct gtatcaaaaa caaaagggaa attgattgtt 2683741 tcagtggtca gcgcagtttt tatcggcagt ttgctgcgct atgccgcgca tgtcatttca 2683801 ggagctgtgt ttttcggcag ctttgctcca aaaggaacac cggtatggat ttattcttta 2683861 acttataatg cgacttacat ggttccttca ttcattattt gtgcaattgt cctatgttta 2683921 ttatttatga cagcaccccg tctgcttaaa agtgacaaag cgtaaaagta acaatccccc 2683981 agcgaattcc gctgggggat ttttcgttat ctgttaagaa gtgtttttaa agctgaaaga 2684041 tccggccagc caagacctac ttctttcagc cttactccgg caatttcaaa gttgtcctcc 2684101 gctactcttt caggtgaata ggcctgataa aatataatcg agggattctg ctcaataacc 2684161 caaacaaaca tacttgaaaa accatgttga agcaaaaact ccgctccttt tgctaagagc 2684221 gccctgcctg caccttgccg ctggcgctct tccagaagat aaatagcgta taactcgccg 2684281 tcatagcctt cttgttcaga gcgaataggt ccaaatgaag caaagccgaa tactgaaccc 2684341 ttttcgtcct gagcaacaaa tactcccttt aacgagcgac ttttccattt gtcttcaaat 2684401 tccttatagt tcaggctgtt taaataatca atcgggataa tttcgtggta tgttgtcctc 2684461 cagctgtcta catgcacttt tgcaatgtcc tttatatcct ctaacttcgc ttcacgtaca 2684521 gttaccatac ggttctgccc tttccttact ctgatttttg gatcgttttg gcttctttga 2684581 tttcatttgt taattcatta atgctttgtt ttacgtttcc ttttcctgaa aagttctcaa 2684641 gcatttcttt tacatcaatt cctgaggatg cttttaaact ttcttgcaga cttgacatta 2684701 agttcgtcgc atagctggtt actttgtttg ctccgcttga ttcaccgctt cctcctgtat 2684761 cgacaacggt gattttatca atatttgaaa gaggtgccgc tgcttgtttc gcgtattccg 2684821 gaagcatttt gacaatcata tcgaaaatcg ccgcctgccc gtactgttca aaggcggccg 2684881 caattttctc ttttgcttcc gcttctgcaa gacctttcag gcggataacc tctgcttctg 2684941 tctctccttt cgctttttcc gcttctgctt ttgctagccc gtcaattctt actttttccg 2685001 cctcagcctt tgccattgct tcaatactgt acttcttggc atcggcttcc gcgagctgtt 2685061 tggctttctc agctgctgcg gactgctcaa cagaataacg gtctgcatcg gcttttttct 2685121 ttacctctga gtcgtattga cgttcacggc gaagaatttc tttttcttct agttctattt 2685181 gtttttggcg ttcgataatt ttaacctgca tttcctgctc tgtgacttgc tggcgcgctc 2685241 gggcagtctc taaatcatat gcttggtcgg cattcgcttt tgccgtatct tgttctctgc 2685301 ggaattcagc cattttgagc tgattgattt tttcagcttc agcgatttcc gtcgcccgtt 2685361 caagttctga tttttttgcg tctttatcgg cttctgcccg cttaattcgg gtttctttat 2685421 cagcctctgc tgttgcgata tcagcatcgc gttttacttg ggcaattctc ggtttcccta 2685481 atgattcaag ataaccgttt ttatcacgaa catctttaat ggtaaacgag acgattacaa 2685541 gtcccatttt cgcgagatcc tgtgaagcga cacgctgcac ctcttgagag aatttttctc 2685601 tgtttttata gatttcttct actgtcattg agccgagaat ggaacgaagg tggccttcta 2685661 aaacctcccg cgcttcctgc tcacggtcgt cttttgattt ccctaaaaat tgttcggccg 2685721 ctgtagcgat ttctcctata gaaccgccga ttttaataat cgcagttcca tcggccatta 2685781 ctggcactcc ttgttctgta tagacttcag gtgtcgaaac atcgagtttg cttgataata 2685841 ggcttagcgg ctctgcctgc tggaagacgg gaaggacaaa ggttcctccg ccgcggacga 2685901 ttttaatacg gttgccgcct tcatcgacat gaacattttt attacccaga tagctccctg 2685961 ttacaattaa cgcttcatca ggccctgctg tacgatactt cgtaataaac acagctatta 2686021 gtgcaattaa taaaaagaat acaactccga tgatcattat aatcggcatt gtcatatcaa 2686081 attcctcctt ttatgttaaa tgggttcatg cggagtaacc gaaagaactc cgttgttaat 2686141 atctacgact aacaccgttg tcccgtaact gatctgctga ttatcaaaac tgaccgctga 2686201 ctttgaaatg gtcccgccta tcccttctat gaccacttca ccaaacccgt caaccggcac 2686261 agctgtaatc actttaccga gtcttcctct gagatcatct tctctatatg ccaatgattc 2686321 ttctgcagat gataatggca ccagtacaaa gatgtgaagc aataccacca gcatgatcga 2686381 aaggatgcaa gataaaagcg caatcagcaa gcttgacaga ggcaatacaa gttcacctat 2686441 atatccgccc gctgaaaaac atgtaaaaaa tgagagcact aatgtcggat taagaaacgg 2686501 aatgccttct gacagccctg aaaatacatc tccgaaaaac aggaataaca gcgtaaggct 2686561 gcccgcaata ataagcgtat aaagatacat tgtttgtata ggtactccaa ataactccaa 2686621 cttcctcatc ctttcttcat caatgcattg atgaacggct gccgttacca tttatacgag 2686681 acacctcggg aaaagtttca aaattttaag acaaataacc catttgaagt gctttataaa 2686741 tgataattgc ttatatatat ggtaatgtca ttttaggagg agatatgatg agtatcttta 2686801 atgaagccag attagaaacg tggaacgaat tgaaaggact ttctgacgaa aagctgaatc 2686861 aaaagccttc tgctgaagaa tggagcatac gggaagttct tgaccatttg aaaaaaatcg 2686921 atatgaccgc acaaaaaatg ttgaaggaac gtgtaaagga cgctccgatt aaagaaattg 2686981 aagaaaaacc gcttgaagta gcacaggaca gaaataataa acggaaagcc ccgagtcatc 2687041 ttgagcctgc gcatgatttt atttcaggca gccaaatgaa acgtgagctt gatgtggtaa 2687101 gagagcagct gactgctgcg attgcctctc tgaaagaaga agattttgaa agagtgcttc 2687161 cgcatcctgt gtttcaagag ctgactgtca gacagtggat cgattttatc ggccatcatg 2687221 aaaaacggca cctcagccaa atgaaagaaa ttaaagaaaa gatagaaagg gcctgattta 2687281 atcagaccct ttctgctttt cgtttgactt ttcgctgata ggaatgaact tctatttcat 2687341 cacctgtgta aacagcacca ggtctctcca caatacagac aatccctcta atgcccagtg 2687401 cgtggcggac gaaagccgac gccagcttcg gttggtccgg ataataagac tgaatgactt 2687461 ctcccggctg gatacacgga tcattttcgc cctcacacag cagagccgct ccgctcggaa 2687521 aaataatccg gcttccttct tttaatgaag taagatctgg cataccgctg actgccacat 2687581 tcgccccgag ccattccggc aaaattctcg gcactcccat ttttaaagcg atttcgttgc 2687641 attcctctat tgaaacaatt gaaatttgtc tgcggttgaa aatttcagtc cctcttgaaa 2687701 acattggttc tctggctccc gcttttttgg tcaggccaaa atgcaagtcg ccggggatgc 2687761 cgccataatc aaaatcaagc ttgtccattt gctttgttac gaagcttttt gtatctgcga 2687821 tatataagcc ttccgctttt gcagtcatac gcttccacat cagctggcac cttccttctt 2687881 atctaaaatt tccacctatg cttcattatc ccaaaaaatc ccgctctgta aaggagcggg 2687941 attttgatta taccgtttta ggcgtaaggt taaagcagcg tttgtagatc cagttgtatg 2688001 ctttttcatt taaatctcta gggtttccga aggtttgcgg atctttcatt gcttctttag 2688061 acaagcgttc gatcatatca ggtgatactc cctgctcttc taaagtcggc acttctaaat 2688121 cttcgaccag atcatacatc caattgacag atgctttcgc agcttcttct gttgtcatct 2688181 tgcttgtatc aataccgaac gctttcgcaa tacgcgcaaa cttctcagga tagcccttcc 2688241 agttgtattc catgacaggg cccatcatcg ccgctacaca ttggccgtga gcgactggga 2688301 taataccgcc aagcgtttgg ctcatcgcat gagcagcgcc cgctgattca cttccgtaag 2688361 aaagaccggc aagcatcgca gcctgcgcca ttccgtacct tgcttccaga tcctctccat 2688421 cagcaaatgc cctcttgatg taatgagcgg catactcaat cgccattaag gcaaccgcat 2688481 ccgtgattgg ctgtgcaaat ttcattgtat agcactcaat ggcatgggcg agcgcatcaa 2688541 ttcccgtcat agctgttaca tgcggaggca ttgaaacatg aagctcagga tcaatgattg 2688601 tcaagtgcgc tgcaatcagc ggaccgcccg tgttgaattt gaattctctt tcttcatctg 2688661 tgataaccgc ccattgggtt acttctgatc cggttccagc tgtagtggga attgtcgtca 2688721 gcggaggaat gcggttttcc agcggttttt tcccatctgc cgcttcataa tcaagcacgc 2688781 ttccttcgtg agtcgcttct actccgattg cttttgctgt atccatggag cttccgcctc 2688841 cgactgccac caaaccatta cagttctctt ttttgtaaag ctcagatcct tcattcacca 2688901 gacggacagg cgggtttggc tcaactttat taaagagtac cacttcaatg cctgcttctt 2688961 taagtgattc gattacggga tcagcaacac cggctttata aatcccaggg tctgtgacaa 2689021 ggagcgcttt tgaaacgccc agtgcagcta cttcctcacc cgtatgcttg atggctccga 2689081 ttccatgctt aatcacagtc ggaatttcaa atgtgtggaa tttctgcatg ctttctacct 2689141 tcatatttaa tgtcatcatc aatctccccc tcttatgaat taaaccagtt aaccgctgcc 2689201 ggttttgtat tgcggtatac atgtttgact tctgtgtatt cttcaaggcc tatttttcca 2689261 agctcgcgtc cgaacccgga ttgcttatat ccgccccatg gcgcttgtgc aaagtacgga 2689321 tgaaaatcgt tgatccaaac ggttcccatt ctcaagcggg ctgctacccg ttcgcacttt 2689381 tcaatgtctt ttgaccatac cgctccagcc aagccataga tggtatcatt cgcaagctcg 2689441 attacctctt cttcagagct gaaggtttcg actgtcaata caggaccgaa aacctcttcc 2689501 tgaacgattc tcatgtcaga attacagttt gagaaaatag taggttcata gaaaaagccg 2689561 ttttgaagct caggatcttc cgggcgtttg cctcctgtct ccagcttcgc gccttcctct 2689621 attccgatct ctacatattt ttctaccttt gccctgtgct ccgccgaaat aagcggaccg 2689681 ctttctgtct cagcatgaaa accgtttccg agttttatgc gttttgcccg tttgaccagc 2689741 tccgccaaaa attgatcatg aatggcatcc tcaacaagca agcgggaacc tgcagagcat 2689801 acttggccgg cgtggaaaaa tacagcgttt aaggcctgat caaccgcaac ttctaaatcc 2689861 gcgtccttga aaacaatatt tgggtttttc ccgccaagtt caagggcgat ttttttgacg 2689921 tttccgcttg ccgcccgcat gatttttttg cctgtttcaa ttccgcccgt aaatgaaatc 2689981 aaatcgacgt ctttgtttac ggcaagctcg tcgcccactg tggctcccgg tccaagaaca 2690041 agatttgcga caccttttgg aacaccggct tcttccatca gcttaaagac tttgattgtc 2690101 gtcagcggcg taatctcact cggcttcatg acgattgtgt ttcctgcggc cagtgcaggg 2690161 gcgattttcc agctcgcttg aaggagcgga taattccatg gagtgatctg gccgcaaacc 2690221 ccgattggct ccctaataat tttgctttct gaatcaggaa tcggagatga aatgatctct 2690281 ccgccatctt tgtctgccaa gccggcgtaa tattgaaaaa cattggcgat atcgtccata 2690341 tcggccttgc tttcttcgag tgtttttcct gtatcaagag attcaagctc agccagctcc 2690401 tcaagatcgc gtctgattaa ttccgcaatt ttcagaacaa tttttccgcg ttcaagcccg 2690461 gatagcgatg accattctcc tttgtcaaat gctctacgtg cggctgcgat tgctttgatg 2690521 gcgtcctctc gccctccctc gcttacagtt gcaatttctt cttgattaaa tgggttgata 2690581 atactgcgga tctgttcttt ttcggcactg atccattctc cgtcaatgaa taatgtttga 2690641 ctcatataag cctccttgac gtaaataaag tttgttaaat aaaaatttaa tgtttttaac 2690701 aaccttaatc taacatatgg tttttaaact gtcaaagtcc cattttgatt tttctttttg 2690761 acttttcctc atgtttcgtt aagataaaga acataaagaa ataacttaac gaatttaatt 2690821 ttctaaagga aaagagggtc agtatggatg aaaatccaga atttgcagct atagaacagg 2690881 ctcgggatct tgttattgac tccattgctg aaacgatgga tctttacgga attacccgca 2690941 gtgtcgggat tttatatggg acgatgtata tgagggatga gatgacgctt gacgaaatgc 2691001 gtgaggagtt gcaaatgagc aaaccaagca tgagcactgg cgtcaaaaag cttcaagact 2691061 taaatgtagt gaaaaaaaca tttcaccggg gcatccgcaa gcatacattt gtggctgaga 2691121 aggatttctt taaatttttc acaaatttct ttccacctaa atgggagcgg gaggttcaag 2691181 tgaatgtaac agcgatcgag gaagctcaag ctgatttaca aaaggtttta tgcaaggaag 2691241 atctcgatga ggatatcaaa aatgaagcac tgcagttata tgatcagctg gaaagctcta 2691301 aagcttacta tgactggctg aaacggcttg ctgaatcggt gcagaccgga gaaattttta 2691361 aatttatacc ggtcgaaaca aagtaaagca gaaaacgcct gggaaactag gcgttttttt 2691421 gatgtaacta ctacaaattt gaaaaatacg ggaaaaacac cccatttact tccaaaatat 2691481 ttgatggtaa ttttatgtag gtaaaatttg tatttggcct ttcagaggag gtgaaaagcg 2691541 ggcaggcctg tttaatttat cattttttag ggggaatttt gttatgaaac gcaaattatt 2691601 atcttctttg gcaattagtg cattaagtct cgggttactc gtttctgcac ctacagcttc 2691661 tttcgcggct gaatctacat caactaaagc tcatactgaa tccactatga gaacacagtc 2691721 tacagcttca ttgttcgcaa caatcactgg cgccagcaaa acggaatggt ctttctcaga 2691781 tatcgaattg acttaccgtc caaacacgct tctcagcctt ggcgttatgg agtttacatt 2691841 gccaagcgga tttactgcaa acacgaaaga cacattgaac ggaaatgcct tgcgtacaac 2691901 acagatcctc aataacggga aaacagtaag agttcctttg gcacttgatt tgttaggagc 2691961 tggcgaattc aaattaaaac tgaataacaa aacacttcct gccgctggta catatacttt 2692021 ccgtgcggag aataaatcat taagcatcgg aaataaattt tacgcagaag ccagcattga 2692081 cgtggctaag cgcagcactc ctccgactca gccttgcggt tgcaactaat gtaaaagacc 2692141 ggttaacgcc ggtctttttt gcgttttacc ctcccctttt tctctaatcc ccgttatctt 2692201 ttttctggtt taaaatttaa attgacaaac actagaaaca ggagtaaatt cttgagtgtt 2692261 caatttcata cagtctcttt taccgcttaa tcaaacacga acgggggaac caacgattgg 2692321 ctgttttatt aacagccttg gggtgaatct tactaagtaa gagggggtac tctgaatccc 2692381 taatccgaca gctaacctcg taggcgtata cagagaggag gtctattatc ggccattctt 2692441 tgcaatggtc ttttttgttt caaaaacgtt aattcactaa gggagatatg aacattggga 2692501 agaattaaaa ataagcaatt tgccgtgatc gggctgggcc ggtttggcgg cagcatttgt 2692561 aaagaacttc atagaatggg gcatgaggtc cttgcggttg atatcaacga agaaaaggtc 2692621 aatgcatatg cttcttacgc cactcatgcg gtaattgcca acgccaccga agaaaacgaa 2692681 ttgctttcat taggaatacg caattttgaa tatgtgattg ttgccatcgg agcaaatatt 2692741 caagcgagta cgctgaccac cctattatta aaggagcttg atattccaaa tatttgggtg 2692801 aaggctcaaa actattatca tcacaaggtg cttgaaaaaa taggcgctga ccgcattatt 2692861 catcctgaaa aagatatggg ggttaaaatc gcacaaagcc tttcagacga aaatgttttg 2692921 aattacattg atctatctga tgaatacagt attgtcgagc tgctggctac gcgcaagctt 2692981 gattcaaaat cgattattga cctgaatgta agagcaaagt acggctgcac gatcctggcc 2693041 attaaacatc atggagatat ctgtctttcc cccgcgcctg aagacatcat tcgcgagcaa 2693101 gattgcctgg tgatcatggg ccacaaaaag gatattaaac gttttgaaaa cgaagggatg 2693161 tagacaaagg tgacacttca aaaggataaa gtgatcaaat gggttcggtt tacaccgcct 2693221 caagtgcttg ccattggttt tttccttacc attatcatcg gggctgtcct attaatgctt 2693281 ccgatttcca ctacgaagcc attgtcatgg atagatgccc tttttactgc ggcttccgct 2693341 acaactgtta cagggcttgc tgttgtcgat accggcactc aatttacggt attcgggcaa 2693401 acagtaatta tggggctgat tcagattggc gggcttggat ttatgacatt tgcggtcttg 2693461 atcgtcatga tattaggaaa aaaaatcggc ttaaaagaac gaatgctcgt ccaggaagcc 2693521 ttaaaccagc cgacaatcgg cggtgtcatt ggccttgtca aagtcctgtt tctgttttcg 2693581 atcagtattg aattgatagc agcactcatt ttatccatcc ggcttgtacc tcaatacggc 2693641 tggtcatccg gcttgtttgc aagtttgttt cacgcaatat ctgcttttaa caatgccggg 2693701 ttttcgttgt ggcctgataa tttgatgagc tacgttggcg atcctacagt gaacctcgtg 2693761 attactttct tatttattac aggagggatc ggatttacgg ttctgtttga tgtgatgaaa 2693821 aatcggcgtt ttaaaacttt ttctttacat acaaagctca tgcttacagg aacgctgatg 2693881 ttgaatgcga tcgctatgct tacggtcttt attttagaat acagcaaccc cggcacgctc 2693941 ggccacctgc atatagtgga taaactgtgg gcctcctatt ttcaggcagt gacgccgaga 2694001 accgcagggt tcaattctct agattttgga agcatgagag aaggaacaat tgtatttact 2694061 ttattattga tgtttatcgg agcaggaagc gcatcaacgg cgagcggcat taagctgact 2694121 acgttcatcg tgattttaac atctgttatt gcttacttga gaggtaaaaa agaaacggtt 2694181 attttccgcc gttccatcaa atatccgatt atcattaaag ctttagctgt gagcgtcacc 2694241 agtttgttca tcgtgttttt agggattttc gccctgacga tcacagaaca agcgccattt 2694301 cttcaaattg tgtttgaaac cttttccgca ttcggaactg tcggccttac gatggggctt 2694361 actcctgaac tgacaacagc tggcaagtgt atcatcattg tcatcatgtt tatcggaaga 2694421 attggtcctt taacgttcgt gttttcattc gcaaaaacag agcaatcaaa tatccgttat 2694481 cctgatggcg aagtgtttac agggtgatat caaaaaaatc cggcgtgcag tcgccggatt 2694541 ttttatgatt cgatatgaga ttgattttgt cttttttcct gttccgcgat gatttcgtta 2694601 tcctccgcgt tatcacgggt cactttttgc gtaagaatcg caccaactgc tacaagtatc 2694661 ataacagcga tgtaataacc tttttcattg agttccagat tatcagcatt atagagtccg 2694721 atactaaaca aaaatactcc cgcaaaaaaa gtaaaataag ctagtactgt aaaggcaacc 2694781 gtgtttctgc gtctatattt ctgcaccttt gttccctccc gaaagcatag ttaaaaagtg 2694841 ataacttccg tggaatatta tacctcaaat tccccggaat ggaacaaaga attaaaaata 2694901 ccagtaaaaa gggcttaggt tgcctccttt atttcaacag ctgaatcatc aatccagccg 2694961 ataagtttat cattgatttg gaattggtac catacagact ggcctttctg ttttttagac 2695021 acaaccttta tgtctttgcc gacgtaagat tgggcagagg taagccttat ggaccgatca 2695081 tcagtagaag gcttggacca tacgtcttga acggcactgt ctttaataga ggcgtttaaa 2695141 tccacagatt tgagggatgg atttacctca tcgtactcat ctaaatcgta tttttccaca 2695201 atagcgctga ttttgtcagc gtagtcaggg tctgtagcat atcctgatgt ttgcagggcg 2695261 gttgccgctt ccttataatt ccctgcctca agcaccggtt tatacttctt tttattccac 2695321 gatgtgccac ggacgaacaa ttgggcgtga tcatccatag attcaaaaaa cgtgctgtat 2695381 tttcgaaact tcgcgcgaat ggtttttctt ttcccttttt caacttcgtc cgtttccatc 2695441 gtgacatgat ggcctttata attccctttt acgccaaaaa ggttgttggc cttagcagcc 2695501 agttcactgt tcccccagtc cgattcgaga atggcctgag caattgtgat gctggggaga 2695561 acatggtatt tttcatacaa aatttgggca tgtccggaca gactgtctat aaatacttgc 2695621 tgttcatcga tttcttcagt ttctttggat atttcaatcg gttttgataa agttgtcgct 2695681 aaaacaaaca gagctagcgg aatcgataca aggaaaaata gtgaaatcaa gagtttacgt 2695741 tttttaagtt ttttacgggc catgaaaacc ttccttcgaa ttaaaagatt acgaatgtaa 2695801 aagaatctac cttttagaat tttacttgca cttctaatat ttttcaattc tttagggata 2695861 aagttgggaa aagattgcaa aataaaaacc ttttcgctca atgaaaaggt ttttaccatg 2695921 tttctatttt tgtaaatttc tgagtgcatt ccgatattcc gtatcattta ttactttata 2695981 tgatttgaca gttgccttcg acaaaccttg tgctgagacg gccggttttt ccggagctgt 2696041 tttcgcttta tcatgtggtt tatgtgccag cttgtgcccc attccagtgg cattcataca 2696101 aaatgacagg cagacgagca gcacgctaag gataaaagaa atgaagaaga gatcatgata 2696161 agcagtcatc atagaatcct gtaccgaacc gctttgtctg gcagcatctt ttttcgtgaa 2696221 aaagccgatg agaatgggaa ctcccatata gacaaacaat cttaaaaact gaacagctgt 2696281 cattctcttg accaaatcag gcagcgggcc tcccatggca gctcccatca gccctgcggc 2696341 gactgtcagg cctgttcccg ctgcaagcat gataaacagt gccgcgaaca tataaagaga 2696401 tgatcgatcc tgtatatgca gccattgaaa attcacaaaa acgagaatga gtccgccgat 2696461 aataccgagc atccctggtc cgactttatc gtataacaga gcgctcaaaa tggccgcgat 2696521 cgccactccg attaaaagag tcaagcttaa aagaatgaga tgctcctgag aaatatcata 2696581 catttgacgg agcaagcctt gaaaagcaga aaggctgaca gctaccgtta tcgtccctgc 2696641 agctatgatc aataagccga gcaccggttt tggcagcagc atcagtttaa tagatatgaa 2696701 ggggtttttc actttatatt ccacaatcaa tagaccaatg agcaaacata acgtcacccc 2696761 gaaaccaatc catacataac ccgatgacag cccccatttt tgcagaaaaa tgaatgaaac 2696821 cgctgaggct gcggcaagga agacagataa aagaattccc gcacgatcaa gcggctgttc 2696881 ttgatccgcc gctccgtgat gctcatcatg aagaaagaaa tagctcaccg cgacaccgat 2696941 cagggacaag gtgccaaaga tgaaaaacag ccatctccaa tgcccgcagc ttgttgcaat 2697001 ggttcccagg attgtaccga tgataacaga accatagaat cccccgatca gcacaagcag 2697061 tgcatagttc ctgcgttcaa tcgggaatga cagtacaagc attggaatca taatcatcag 2697121 catgacgcct gttgccgccc cttgtaaaaa gcgccctgcc gccatcaatg caatatcgcc 2697181 tgaacatgcg atgagcagtg agcctagtat aaagacaggt aatgaagcca gatagacggg 2697241 acgagcaccg aattttttcc tcagcagcgg tcctgccgga actaacaagg caaaggccat 2697301 attgccgatc aatatcggat ttactgatgt aaagacactt gttccaaccg ttttctgaac 2697361 aaggccttga actgacgaca atgccgtgtt agacatcaat cccggcccga ccgctaagac 2697421 ggcgagcaaa gaaatcaccc aatagtgttt tgtcttcatg ttgtcatccc ttcctatatg 2697481 aatacatgcg aaacacatca ttttttgaaa acaaaagaag ctaatagatt ttgcatacca 2697541 ttagctttca ttctaatatt ctccctttca ggggaaatga tattatttta ttataattat 2697601 gtgaatgaat gagcatataa tcaaatatta tttcaaatcg attgtgtttt gtcaatggag 2697661 taaatttcaa gcacaacata gaaagcttga aagcttttcc ccgatattgt gtctagaact 2697721 gcacttatga atccctgctc gttccctcaa gcgaattaaa gcaggccgtt ttaatccttt 2697781 caatccacta ttccaactaa taaactcaaa taagttggtg ataagacaac attttacccc 2697841 cacatttttt tgtgttcact gggcgtttgc cgcctctaaa ttgtatatgg gtaaatacca 2697901 tgaattaacc tatgaaatac caatgtaagg gaggcaaaaa cgaatggaac tgtatgagtg 2697961 tatccaagac atttttggcg gcttgaaaaa tccatcggtt aaagatttag caacgtcttt 2698021 aaaacaaatt ccaaacgcag caaaattgag tcaaccgtat attaaggaac cagaccagta 2698081 cgcttacggc cgaaatgcca tctatcgaaa taatgaattg gaaattatcg tgattaacat 2698141 tccgccaaac aaggagacaa cagtacacga tcatggtcaa tccattggtt gtgcaatggt 2698201 gttagaagga aagcttctta attctattta tcgttcaacc ggcgaacacg cagaactctc 2698261 caattcatac tttgtccacg aaggagaatg ccttatttca accaaaggtt taattcacaa 2698321 aatgtccaat ccaacatctg aacgaatggt gtctcttcat gtctactccc ctcctttgga 2698381 agacatgacg gtctttgagg aacaaaagga ggtattggaa aattcatgat tgacagataa 2698441 actgctcact ttgacttcac tcaactggag gattcagaga atgaaacctt ttcctcaaaa 2698501 caaaaaaacc cttatcgaat aagggtttaa aggtatggag ccaagggggc tcgaacccct 2698561 gacctctacg ctgccagcgt agcgctctcc cagctgagct atggccccgt atgtaacgtc 2698621 atgtttatta tagatgattt tattttgaaa aacaagctgt ttcctcttga attgacagaa 2698681 aaaataaggc tcggaaaaga gccttatttt tcgacttaca tcatgatcaa aagtaaaatc 2698741 acaccgagaa taattcgata gattgcaaat gggacaagtt tgattttgtt aatcagcctt 2698801 aagaagaaac ggacgacaaa cagtgcgacc acaaaggcac agataaagcc gacgatgaaa 2698861 aacggcatca gatccgaact taagctgtcc caatgcttca cgaggcttag aaagctggct 2698921 cccatcatga tcggcatcgc cataataaac gtaaagtcgg ctgcagctcg gtggtttaat 2698981 ccgagaataa caccgccgga aatggttgaa cccgaacgcg agaaaccagg ccaaagggaa 2699041 agacattgga ataagccgac ggctatcgcc tgtttatagg aaatgcggtc gagtgtgtct 2699101 gtcgctgttt tccgtttatt gacccagtca gcaaaaagca tgaggattgc cccggcaatt 2699161 aaaccgatgg ccacagtttt aacggaaaat aaatattcat caatgtaatc ttcaaacaaa 2699221 aagccgagaa cagctgcagg cacgagtccg acggcaattt gggcaatgct taatttatgt 2699281 ccctgctcct ggtcgcttgt aatatttttt ttcaagccca gtaaatttaa aattcggtct 2699341 ttaaacacga tagctactgc taaaatggag cctagctgaa taaccacctt gaatgagtta 2699401 gcagcttctt ctgacatcag attacttgat tttagccaga tgtcgtctac tatgatcata 2699461 tgtcctgtcg aagaaaccgg cgcgtactct gttaatcctt ctacgattcc taaaatggcg 2699521 gctacaaaca attcccatag agtcatgatt ttgattctcc ccattagaca tttatttttt 2699581 tacataacgg gagcttccca taaatggaaa gcccgtctta tataactata aacgaaaatc 2699641 acactttatg ccccggcgta ttttcatttt tttcttcatc gtataaatgt gactgcattt 2699701 taaaccagtc aaataaatgt gtcgtaatga ctttggcaac cgcatagccg ggaatcgcaa 2699761 gaatgattcc aacaacgcca aacagcttgc cggctgttaa cagcagaaaa ataatcgtaa 2699821 tcggatggat gtgaaggttt tttcccataa tttgcggaga gatcagcttc ccttcaatca 2699881 gctgaacaat cgtccaaacg atcaccagct taagcagcat gagcggcgat gtcactatgg 2699941 caatgataat cgcaggcgta atggcaatcg ttggccctaa atatggaacg atgcttgtgc 2700001 aagccgcaat gactgcaagc aatgaagcat aatccagccc gataatcaaa taaccgataa 2700061 acagcaaaaa cccgatacag aagctgacaa tgatctggcc tctgatataa gagcttaacc 2700121 gatgattcat ttcgcttaag actgtatatg tctgttcttt caatcgagtc ggcacaaact 2700181 tcagtatgta gaccggtaat tttcttccgt cttttagcaa ataaaataga ataaacggaa 2700241 ccgtgacgat cgaaatgata atctcagtca gtgcgccgat aaaattccca acaccggtaa 2700301 aggtgctgtt cacgatcgtc gctgcctgat ccgaaacctt tgtagcaaga tcagatatat 2700361 taatgttcat cgtttgctgg gcctgattga cgaagttgct gccaatcagc tgtttcgtct 2700421 gattttctac gacgtccaca tatctcggga tattgtcaat caaactcata atttgttctt 2700481 ttaagaaggg aatgatcgac acgatcgtga tcgtgatcag cccgataacc aataggtata 2700541 gcagcaatat agaatagatt cttcttattc ttcttctctc cagaaaatcg acgactgggt 2700601 ttaacagata aaaaacaatg cctgtcaaaa taatcggaag tgatatcgtt ttgagcagaa 2700661 caataatcgg ggtgaaaata aatgatgttt ttgtaaatac tagaatattt aaaccaatca 2700721 gcagcagcac aagcaaaaat aaaacaaact tattatccaa gaagaatcgc ttgaatctgc 2700781 cgctccatgt ttgcaacgtc tccactatcg ttcctccgtc atacatagtt taattaaatt 2700841 gtacactatc gtccctataa tgaaaaataa aaaccgttaa ttgctggaaa agctttctcg 2700901 gttttaacat tctatttata tctatcatgt gattttgttc tttttaagct ataatttagc 2700961 tatatcatgc aaaaggagcg atacgagtga tacgttttgc aataatagga accaactgga 2701021 ttacagaccg ctttcttgag tcagcagcgg atatcgaaga ttttcagctg actgctgttt 2701081 attcaagatc ggctgaacgc gctggcgagt ttgctgctaa acacaacgct gcgcatgcct 2701141 tctcagacct tcaggaaatg gcggcgagcg attgctttga tgccgtatac atagcgagcc 2701201 cgaacgctct tcacaaggaa caagccgttc tctttatgaa ccatggcaag catgtgcttt 2701261 gtgagaagcc gtttgcttcg aatacaaaag aaacagaaga gatgatctca gcggctaagg 2701321 caaacggcgt tgttctcatg gaagcaatga agaccacttt cctgccgaat ttcaaagaac 2701381 tgaaaaaaca cctgcataaa atcggcactg tccgcagatt taccgcaagc tactgccagt 2701441 attcctcacg atatgacgcg ttcagaagcg gaactgtttt gaatgcgttt cagcctgagc 2701501 tttccaatgg gtcattaatg gatattggcg tctattgtat ttatccggct gttgtgttgt 2701561 ttggcgcgcc gaaggatgta aaagcaaacg gatatgcttt atcctccgga gtggacggag 2701621 aaggaactgt cattctgtct tacgacgggt tcgaagctgt tctgatgcat tccaaaatct 2701681 ctacttccta tgccccggct gaaatccagg gtgaagacgg gacgattgta atcgatacga 2701741 ttcaccggcc tgaacgtgtt gaaatccgct accgggacgg ccgccttgaa aacatcgcga 2701801 tccctgatcc taaaccggcg atgttctatg aagcagaaga atttgtcacg cttataaaag 2701861 agaataagct ggaatctgaa gaaaatacat ttgaacggtc tttgaccacc gcaaaaatta 2701921 tggaagaagc aagaaagcaa atggggattg tataccctgc tgatcaagct taaaaaaatc 2701981 cgcccgcgtg caaatgccgc ggcggatttt ttattagaca atcggagaag atgccttcct 2702041 ttttaaaagc acctgttgct catattcttt gatgtcataa agccatgcct cttttaccgg 2702101 aacgcccatt tgctcacagt aggaatccca gatggctccg aaaggatatg ttttgaattc 2702161 ctccatcagg gccagccttt ctgtatagcg gccctcttcc tgcaattgtt ttaaatatcc 2702221 gttcgggaga agcagggcat acaataaagc tttgatcata tttctcgttc cgatggtcca 2702281 ggcggctaca cggttaatgc tggcatcgaa aaaatccaga ccgatggcta ccttctcaag 2702341 agcatgattt cgtacaattt caagagcgat ttctctcaat tcatcatcca aaaccactac 2702401 atggtcgcta tcccaacgaa caggccgcga tacgtgcaag gcaagcttgt ctgtgtaaag 2702461 cagcatggac gagatcttgt ttgataccgt ctcagtcgga tggaaatggc ctgtatcaag 2702521 taaacaaagc ttatgattcg tcaaagcata agctaaataa aattcatgag atccgacaac 2702581 atatgattcg gagccaagcc cgaacagctt gctctcgatt gaatcaagat tatgttgttc 2702641 actgatctcc tctgagaaga tccgatccag tgattctttt agtcttttac gcggtgtcag 2702701 cctatcactc gggatatcct tatagccgtc gggaatccaa atattcgtca agcaaggtgt 2702761 tcctaattct ttcccgaagt attccccgat acggcggcaa gcgatgcaat gcctgatcca 2702821 aaattctctg atgtccggat cagggtgtga aagggtgagt ccgtcagccg ctttctcatg 2702881 cgaaaacaag gttggattaa aatctaaacc gagaccaagg ttttttgccc atttcaccca 2702941 gttttcaaaa tgctgcggct tcaattcgtc acgttctacc gcttccctgt ttgtttctgc 2703001 gtatatcgca tgcaggttta cgcggtgctt tccaggaatg agagaaagag ccttctccaa 2703061 atctcttctt aattcttcag gagtttgcgc ttttccggga taattgccgg tcacgtcaat 2703121 tccgcctgaa agctcgccct tatttacttc aaagccttca atgtcgtcac cctgccagca 2703181 gtggatcgaa atgggcactt gctctaattg ccgaagcgcc tcttcaacat caattcccca 2703241 tttttcatat gcctgttttg cactgtcata attggctttt atggtcatac ggctctctcc 2703301 ctttatcagt ttttcaatcc aaataaaaaa cttcctttag atctatcgca acaggactga 2703361 aatccgaatt tgttttcatt aatggcgcca tcgatttcca ccatctttgg caaacttccg 2703421 tgtccgccat ctttctccat ttctcttcat cctctatttc taaatatgca aaaagcctgc 2703481 ctgtttcctc gtctagaaaa atggaataat ggtgtgctcc atgagctttg agtgcttctg 2703541 ccatctcagg ccaaatgtca tcatgccgct gtttgtattc ttcgtacttg tcttgatgga 2703601 caaacatgat actggctttt cttttcaaac cttttcacct cttcatcatt tagatagcgc 2703661 tttcaaaaca gtttgctgaa atgactgaat gatcgtgctt ctatcaatgt ctttaggtgt 2703721 aaacactttg atcggaaagg aatttctgac gacttgccgg gcttctttta tgtctttgac 2703781 ttctttggca gcaatcattt gcatcaaaag atttccggtg gcagttgcct ctatcggccc 2703841 tgcatatacc gcttttccac tcatgtctgc cgttaattga tttaagaaat cattccgggc 2703901 tccgccgccg atgatatgaa attgctcgat cggtttttct gtgattgttt cgagctcttt 2703961 gatggctatc gcatagatga tggctaaatt gctgtagatg cagcaggcaa gttcgcctgc 2704021 agtacgggga atcttttggc gggtttgtct gcaataatgt tgtatttcct ttatcatgtt 2704081 ttctggattc aggaaacgtt tatcatttaa gtttataaat tgctggaatg gttctgtttt 2704141 tttggcttct tctgcaagct gctgaaaaga ataatctgct tgtagctgct gtttgacttc 2704201 ttgtatcacc cacatgccga taatgttttt gagaaagcga atggtgttgt ttgcgccgcg 2704261 ttcatttgta tagttgtttt ctaaagcaag atcagttatt atcggtgttt tgttttcaac 2704321 cccgattaac gaccatgttc cgctgctgat atacgcccag ccatcattta cgcctggcgc 2704381 cgcaatgacg gccgaggccg tatcatgtgt tgcgactgtc atcaccttgc acgccgggag 2704441 atcataatcc gggaaccact catttcttag cttcccgagt tcacaccccg gttcagtgag 2704501 cggcgcaaat tgctgttcca gaacagacac ggcttcaagc aattcaggat caagatttcc 2704561 cgttgagacg tttaaaagct gtgttgtgga cacgtttgtg atttccgtta cagcttttcc 2704621 ggttaaacaa tagcctaaat aatcaggaat catcataatt ttgtctgtct ttttcagcag 2704681 ctcacggtct tcttcaaaca attgatagat cgtgttgaaa ggctgaaatt gtattcctgt 2704741 tttttgataa attgcggctt ttgagagggt atgttccagt ttgtctattg tgtgatctgt 2704801 tcttctatca cggtaggaga ttgcttcccg caaccgatcg cctttttcgt ccagtaagac 2704861 ataatcgact gcccatgtat caatgcctac ggtgcagtgt tcatacccaa gcgtctttac 2704921 tttttgcagt ccttgcagga tttgttttag caaatgatca atatcccata agcaatgccc 2704981 gtctctttga ctgaaaccgt tagcgaacct gtgaatctct tgtatgtcaa gcttcccttc 2705041 attcagttca cctaccatga ttctcccgct tgatgcgcct acatcaatgg cagtataaat 2705101 catcctttca ccctctcttc gaaagaggaa cagctgtcac cttcaccttt ttgtcctcaa 2705161 gagcttttac cgatgccgga tcaagtccag aatccgtaat aaggcggctg acatcttgca 2705221 gcgaggcgat atgtgaaaac tcgcggttcc cccatttgct tgaatcggcc atcaaaatgg 2705281 tctggtccga cctttcgatc atccgttttt tgagcagcgc ctgccactca tttgaatcac 2705341 tcatcccgtt gtgtacgtca aatcccttac atgacagaaa ggttttattg acatgatagg 2705401 tctcaagtga acgctctgct aacgggccgg caaatgataa tgatttttcc agcaaaatgc 2705461 cgcctgttga aatgactgat atgttttctt tattgctgag ttcaatagct gctttcattg 2705521 agtttgtaat cacggtgagc tcaatgtcag ggagtatttt tgccatgtac caagcggttg 2705581 tgcttgcatc gagaatgatt cggtctccgc tttttacata tttggccgct tcgtgagcga 2705641 tggctttttt ttcgatgaca ttcgtgattt cccgttcaga aaaatgaatt tctgattcct 2705701 tctgctgaat actgaccgct cctccgtggc tccggctcag tttatgttct ttttcaagct 2705761 tttcaagatc acgccgaatg gtttcctctg tgactgaaaa aatgtcactt aattcggaaa 2705821 cgcggatgct tgaacgcata tttactattt ccactatttt ttgctgccgt tctgctacta 2705881 gcatcggtaa cgcccttcct catatcgtag tccgtcttat atttttatca tagcatatat 2705941 ctaacgcgta aaagcagcag ggacgccgcc gtctaccgtg atcatgcagc ccgttgtttt 2706001 ttcggctttg gaagaagcga agaatgcaat ggcttcggca atatcctccg ggtaaatatt 2706061 gacgagcaat gctgtccgtt tccggtaatg ttcctccagc tgatccggtt caatcccgta 2706121 cgccgcggct cgttcctcac gccagcttga accccagatt gccgatcctt gaagaactgc 2706181 atcaggcaaa acggagttga ccctaatgcc gaattctccg ccttctgctg cgatgcatct 2706241 tgctaaatgg gtttcaagcg ccttaacaga gctgtaggca gaggcgtttt ttcccgcata 2706301 aactgaattt ttcgatccga caaataccat gcttccgcct ctattttgat gtttcatctg 2706361 tttaaacgct tcacgggcta caaggaaata gcctgttcct aaaacattca tattaagatt 2706421 ccattctttt agacttgttt cgtcaaatgg gcttgatgtg gccagcccgg cattattgac 2706481 gacgatatca atgccgccgt aagcaagcgc cgctcgttca aaagctgact gtacgtcttc 2706541 ctcctttgtc acatccattt tgacagccat tgcccgtcct tttccgtatg catcgtttat 2706601 ttccccggca attttctgtg cgccttctat attcagatca gctacgatca cgtgccctcc 2706661 ctcagctgca aatcggcggc atgccgcact gccgattccg ccggctcctc cagttatcag 2706721 cgctactttt cgggaaaatt ctgcttccgg cggggccagc gtgagtttat atagttcgag 2706781 cggccaatat tcgacatggt aggactcatt ttcatgtaaa gaaacaaatt gccccagagc 2706841 ggttgctcct ttcattacgg cgatggccct ccgatataaa gccccgctta ctttagacat 2706901 cgcataactt tttcctgtat tcaccattcc gattccagga atcaatatca cccgcggggc 2706961 ggattcaaag atttgatccc catcctgctg attgcgtgta aagtaagcct gatactctga 2707021 tgtaaaggtc tcgactcctg acttgatcag atctgcaagc ttgtgcacat cttgagtttc 2707081 cggattccaa tcaatgtaca gcggaacccg ttttgtgtga acaaggtgat ccgggcatgc 2707141 cgcaccgatt tgcgaaagtg ctggcgcttg gacactgttt acaaattcca agacatcgtc 2707201 atgatcatca taggaaagga tcattttctt ttcttcactt actgctcctc tgatcacagg 2707261 catgatgcct gccaagattt gttttctttt atcctccggc agcggctgat accttttgcc 2707321 tccgaatacc tcatgctgat tgatacgatc gttaatatac tgctcggctt cttgaatgat 2707381 ggatatcgtt ttttgataac atgtttcaga cgtctctccc caagtgacta agccgtgttt 2707441 ctccattaat acaagctcgg cgtgggggtt gtttgctacg ccttcagcga tcattttaga 2707501 caaagtaaat ccaggacgga cgtatggcac ccatacaaac cgatttccgt aaatgtcttc 2707561 agcgatttgt tttccattat ccgcacagca tatgctgata atcgcatctg gatgggtatg 2707621 gtcaacatgt ttgtatggca gaaaagcgtg taatagcgtt tcaattgaag ggcggggatg 2707681 tttgctgtct atcatacaat gagacaggta gtctaccatt tcttcatcgg gcatttggtc 2707741 ccttttaatc agcgggcgga tatcatctaa tttcaaaccg gaaaagttat gcgctttcat 2707801 tgttgccaaa tccgatccgc ttccttttac ccacatgact tctatttcac ggcctctaaa 2707861 atccttttcc gttgttttca tagatgtatt ccccccgccc cagttgcaga cagtgcggtc 2707921 tgacccgatc agattggacc tgtacaccaa ttcctctaca cctttaggta gctgtgcagc 2707981 tcgctctgaa tcccatatat gtttcaccat atttgatatt cctccatacc cttttatttg 2708041 tatccgtttt cattatatat gatttctgtt tgtttttgaa tcgtttttgt ttatttttgc 2708101 tttttaacaa aaaaagaaag cagcagatat gccgctttct cgtttcatta tgattctatt 2708161 ttaaatttct tcgtaatgtc ctgaagttct tccgccatgt ttgccaacgt ttccgctgaa 2708221 gagctgattt cttccatgga cgcaagctgt tcttccgccg aagctgcgat atcctgaatg 2708281 cctgctgagc tttctttcgc cactgcagaa atatcttcaa cagcacttga cacttcctgt 2708341 gatccggctg acagttgttc aaccgtcgcg ttcaagtttt gcaattcgcc ggaaatttgg 2708401 gttgtcatct catagatttg tttaaagctt tccgctgttt gatccgtaat ctgcaagcct 2708461 tctttcactt catgattcac ggattggaac attgaaagtg aggtgctgat ttccctgaca 2708521 atctcttgaa ttaatccttc aatttccttg gcggagtctg ctgattgtac agcaagtttt 2708581 ctaacctctt ccgcaactac tgagaaacct cttccgtatt ctcccgctct tgccgcctca 2708641 atcgcagcat ttaatgcaag caggttggtt tgatcagcaa tgccgttaat cacattcaag 2708701 atgcttgtga tgtcttgcga ttttgtttca aggcccttca caaccgcttc cgctttttga 2708761 acggattggt caattgtttt catctggccg actgtatgct ccaccagctt ttctccgctg 2708821 cccgctgcct cagaggactg aatcgatgat ttcgtaatgg ttgaagaggc ttgagccact 2708881 tttgaaatcc cctcgttcat ttgagaaaga tgatttgagc ttgtttccag tttctcgctt 2708941 tgtgcctcgt tgccatctga gaactgttcg atggcaagtg taatatgttc agttgccttg 2709001 cttgtttggg ctgcgcttgc tgtcagctcc tcagaagatg aagcgacgtt ttctacagac 2709061 gtttgaataa cgcctattac agaacgcaat gatgcagaca tttcattaaa gctttcgcca 2709121 agctggccaa actcgttttt cgagtgaatg tcaatgactt ctgtgagatc tccgctgctg 2709181 atttttgcag acgttgagac aagttttctt aacggcttgg tgatggcacg gataatatag 2709241 agtatgagta tgccgccgat tactattgac acgcatagaa tgataaccgc agtgttcagc 2709301 accgggcttg aagcatcttg caattcactg acaaaatatg tgcccgcgat tttccagcca 2709361 gtcagtttat ttgtcgtaaa ggccattttc ttttctttgc cttcgaatgt atattcaaat 2709421 gagccttctt ttttggaata tacttggttt gtccaatcgc cggaaccggt tgtccccggc 2709481 ttaatggtcg gatgggcgat atattttttg ttgcctgtcg taataaatgc aaagccttct 2709541 tttccgattt tgattctttt tgatgcagta agcacttcat ccaggtttaa atctagcgct 2709601 ataacccctg aaccgtcttt taattgtttt gaaattgtga caacgatatc tcctgtcgct 2709661 tcatcggtat acggttctga gaaaacagct tgtccttttt ccgcaaccgc ctgtttgtac 2709721 cagtcacgtc ctgtcggatc gaaacctttc ggaacaccgc tatccggata tttataaagc 2709781 ttcttatctt ctgaggcagc atagattgcg cctacatcgt cgttaagtgt cgtgtactgc 2709841 ttaaatttct ctttcagtaa tgttttgttt ttgcctaaca atatgtcttt atcgactgtc 2709901 tcactataat aatctattgc ttttacttta tcttctaatt tattttgcag cgtactgttt 2709961 agttcttcaa catttccctt cgcactgctt atgagctctc tgtctaacgc gttccaagct 2710021 gattgataac tgaaatatgc taaaacccca accggcaaaa taagcactgc cagaaacgca 2710081 gcgattagcg gtttgctgat cgatggctgt ttgatccatt gtatgaattt tcccattctc 2710141 gttgactcct cctttaagat aaatctaata tcgtcaaact aggataaaag gtttaataaa 2710201 aaaactaaaa aaaacaccca agcgcaacaa gcttgggtgt taaggcttat tattcaattt 2710261 taaatcgttt ggtcatatcc cgaagctctt ccgccataga ggaaagggtc tctgcagacg 2710321 agctgatttc ttccatggaa gctagctgct cttcagctga cgccgcgata tcttgtatat 2710381 gcgctgagct ttcttttgaa atcgatgcaa tgtgctcaga cgctcccgaa acttcttcgg 2710441 agctggcaga aagctgctga accgtcgcac tcatattttg cagttcgccg gcgatttggt 2710501 tcgtcatttc agaaatgcgt ttgaagctca tttctgtttt atctgtgatg tcaagtcctg 2710561 tctgcacctc ttgattgaca gattggaaca tgccgagtga tgtattgatt tccttcacaa 2710621 tttcgatgat taatccttca atctcttttg ctgaatctgc tgactgtact gccagttttc 2710681 ttacttcttc cgctacaacg gagaagccgc ggccgtactc gcctgcgcgc gctgcttcaa 2710741 ttgctgcgtt taaggcaagc aggttcgtct ggtctgcgat gccgttgatc acacgcaaaa 2710801 tgtttgtaat atctttcgat ttcgtttcca atccgcgtac gacttgctcc gcttctttaa 2710861 cggacttgtc aatgacattc atttggccga cggtttgatg aacaagcttg ccgccttcac 2710921 ttgcaatttc tgtcgattga acagatgaat cagtgatcac ttcagaagct tgagccatat 2710981 tcgtcaaccc gtcattcatt tgataaatgt gctctgctgc cgtttcaatg ttttcgtttt 2711041 gtttttcatt gccgttagaa aattgttcaa tcgccaatgt aatgtgctct gttgccttgc 2711101 tcgtttgcgc agctgatgca gtcagctcct cagaggaagc ggcaacattg tctaccgaat 2711161 cctggatggc gtgtatgaga gaacgaagtg acgacgccat attgttaaag cttttgccga 2711221 gctcgcccaa ttcatctttt gaacggatat caatggtttc cgtcaaatct ccctcgctga 2711281 tccgcttaga ggaaccgaca agctgtttca gcggtgttgt aatcgaccga atgatcaatg 2711341 tcatgacgat aatccctatg ataatagctg cggccaagac aattaaagca aggtgaagga 2711401 caggctgggc tgcctcatgg atttcatcca aatacatggt gccgccgatc ttccatcccg 2711461 tcaacttgtt tgtgtcaaag gccatttttt tcttatcgcc atccatggtg tattgaaaat 2711521 cgcctttatc agcactcaac atcttatcga gccagtcgcc ttttaattca gttcctgatt 2711581 gttcattagg gtgtgcgaca acttttttgt ccttcgtcat gataaatgcg tagccttgtg 2711641 tgccgatgtt gacttttttg gttgttttca gcagattttc aatcgtcatg ttgattgcga 2711701 taacgcctga accatctttt gtctgctggg cgattgtcac aaccatcgta tttgtcgacg 2711761 cggttttata agggtctgtg atcacgactt tccctttatt tgcaaccgct tttttgtacc 2711821 agtcgcgttc aaccggatta tagccgcttg gcatcggaag atccggatag cgggtaaagt 2711881 gcccttttgt gtcacttgta taaatggatt ctacatcctt gttaatgctg atatattgtg 2711941 agaatttctc tgcaatgctt gcattgcttt ttgcattgta tttctctttt gtcagccatt 2712001 cgctgaaata atcagcactg ttttcttttt cgccgatgct ggtgttaatg atttcgttta 2712061 attgctgtac attttccaat gcgctcccca tcatctgtct gtcgagtgag ctgctagccg 2712121 attgatacgc aaagatcgcc aatatgacaa ccggtatgat gaggatcgac agaaaggaaa 2712181 cgagaagctt ccgtgtaatt gatctttgtt ttatgagttg gagtattttt ttcatcattc 2712241 atttctcctt ttttatgcta cccttcatat cggctggaaa tgggtaaata tatacagcaa 2712301 aaaagaagaa atttaacaaa agtaactaat ttcccataaa taaatagtat tttagaccta 2712361 ttatttgtct actttaaatt gttttgtcag atcacggagt tcttcagaca ttctttcaag 2712421 cgtcagtgca gatgaactaa tctcctccat ggatgccagc tgttcctcag ctgaagcggc 2712481 gatatcttgg atgccatccg agctttcctt agaaatggca gtgatatcat ttgaagctgc 2712541 ggaaatttct tgagctcccg ctgacagctc ctcaaccgtc gcattcatgt tttgcagctc 2712601 ggaagcaatt tgattggtca tttgcgatat atgtttgaag ctctgtttag tttcatccgt 2712661 catgacaagc cctgtttcaa cttctttgtt tacggactga agcacgttca gtgatgtgtg 2712721 aatttctttt actatttcac tgatcagcga ttcaatttct tttgctgagt cagccgactg 2712781 taccgcgagc tttctcactt cctcagcgac gactgagaag ccccggccgt attcacccgc 2712841 tctggcagct tcaatggcgg catttaaagc caaaagattg gtttgatccg caatgccgtt 2712901 gatgacacgc aaaatattcg tgatatcctt tgatttgatc tccagccctt tcaccacttg 2712961 ttccgctgct tttacggaat ggtcaattgt gttcatttgg ccggctgttt tctggacgag 2713021 tgtctcccct ttgcttgaca cttcggttga atctgcggat gtttctgtaa tcactgctgc 2713081 agcccgcgcc agctctgcca atccgtcatt catttcatta atttgttcgg ttgtcgtttc 2713141 tattttctcg ctttggcttt cactgccgtt tgaaaattgc tcgatagcca tcgtaatgtg 2713201 ctcagtggct ctgcttgtct ggtctgccga tgcagtcagc tcttcagacg aggaggcaac 2713261 gtgttctact gagtctttga tcccgtgaat gagcgagcga agcgagtgtg ccatatgatt 2713321 gaagctctca ctcagaacgc cgagttcatc ttttgaattg atttcaatcg tttcggttag 2713381 atcgccttca ctaatttttt cagcggatgc gacaatgcgt ctcaatggct ttgtgatgga 2713441 tcgaatcaca aaataaatcg ccgtcattcc agctccgatg gcaatcgcca gaacgattga 2713501 agccatgatc agaaccctgc ttgcagcatc gtgaatctcg tttgcataca tcgtgccgct 2713561 gattttccag cctgttgttt ggcttgttgc aaatgccatt tttttctttt tgcctttgta 2713621 cgtatattca aagtccccgc ttttatcctt gtagagctta tcaacccagt ccccttttag 2713681 ctctgttccc gctttttctc cggagtaggc gatgactttc ttgttttggc tcaaaataaa 2713741 agcatagcct tcttttccga tattgattcc tttcgcggta gtgactaagt catcaatttt 2713801 catatcaatg gcgacaacgc ctgacccatc caccgtttga cgggcgatgg tgacgaccat 2713861 ttttcctgat gaaatcgatt cataaggctc agtgacaatt gttttgcctt tattggccat 2713921 tgcttctttg taccaatctc gttccaaagc attaaagtcg cttggcatgt cagcgtacgg 2713981 ataacgtgtg aagtccccgt ctttgccgct tgaaaatacc gcagcgacat tatcattcat 2714041 ttggataaat tgtttaaatt cctgtttcag ctctgttttc tttttatcct gaaatttttc 2714101 tgctgtagcc caatcgctga aatatgcgag gcttttttca gtagtgctga ttttatcatc 2714161 aatgatgtga tctaatatct gaacattttc ctttgcgctt tgcgtcatct gtacatcaag 2714221 tgaggcaact gctgattgat aagcgctaac cgaaagggcg gttatcggaa caattaagat 2714281 cagcaggaaa gaaataataa gtctccttgc aattgatgat ctgcgaatag tggtgagtgt 2714341 ttttttcatt tccttttgaa ccttctttca ataatttaca aattatatcg gcggatcttc 2714401 ctttaaatta cattgaaaat ggaggaaaaa atgaaaaata gttctaaatt cacctgttaa 2714461 actaggactt tattattgtt taccatataa aaaaacagcg ctttgatagc gctgtttttc 2714521 ggtttttact cgattttaaa ttgtttcgtc agatcgcgaa gctcttctgc catctgcgca 2714581 agagtcgtcg ctgaggaact gatttcttcc atggaagcaa gctgttcttc agctgatgcg 2714641 gcaatgtcct ggatgcttgc cgagctttct ttcgacacgt ctgcaatgcc gctgactgct 2714701 gctgaaacat gctgtgaacg gtctgacagc tgctcgacgg tggaattcat cgtctgcagc 2714761 ttgcccgcga tttcgtttgt catgctgaaa atgctctgga agctttcttt tgtattgtct 2714821 gtgacaacaa gtccggactg tacttcctga ttgacctctt taaacatgtg aagagaggtg 2714881 tcgatttctg cgacgatttc ttggatcagc ttttcgattt ctttcgctga atcggctgat 2714941 tggacagcca gcttgcgcac ctcctccgct acgacagaga agccgcgtcc tgactctccg 2715001 gcacgcgccg cttcaatggc tgcatttagt gcaagcagat ttgtttggtc agcgattccg 2715061 ttgatgactc tcaaaatgct tgtgatgtct tttgattttc cttctaagcc tttgacaaca 2715121 gcttcagcct gctgaacaga ttgattaatc gagttcattt gtccgactgt ctgctgcaca 2715181 aacttctcac ccgttccggc gatttccgtt gattggatag atgcctttgt aatatctgac 2715241 gatgtttgtg agacttgctg gagtccttca ttcattaagt tcagctgatg agagctggat 2715301 tcaacctttt cgctttgctc ctcgtttccg tttgagaact gctcaatcgc catcgtaata 2715361 tgctcggtgg ctttactcgt ctgcccggca gatgcggtaa gctgttcgga agatgcggcc 2715421 acattgttca ccgagtcctg aatagcgctg atcagagagc ggagagattg tcccatttca 2715481 ttgaagcttt ccccaagctc tccaagctca tcctttgaat ggatttcgat cgtttcggtc 2715541 agatcccccc tgctgatcgt tttcgatgat tgaacaagac gttttaacgg ttttgtaatc 2715601 gaacgaacga taaacagaat taaaattccg cctgccacaa tggaagcaat cagcacaatc 2715661 attcctgttg tcagcacaga ctttgaggca tccttaattt catccatata cattgtgccg 2715721 gctattttcc aaccagtcag ttcgtttgta gtataggtca tctttttatc ttcgttatta 2715781 agagtatact ggagttcacc gctgtcattc gcatacattt tggctaccca gtcgcctgaa 2715841 agcttttctc cagccttatg gttcttgtgg gcgacatagg ttttgttttt tgttgcaatg 2715901 aaagcataac cttcttttcc gaccttgatt tgtttcattt gttctaacaa tttatcaatg 2715961 gtaatatcca tggcgacaac gccagatccg tccttcagct cctgtgcaat ggtaatgacc 2716021 atgcttccgt cactcgcagc cacgtaagga tctgtcacga caatttcacc gccggccttc 2716081 atcgcatcct ggtaccaagg ccgttgtctc gggtcgtatc cttccggcaa tttttctttt 2716141 ggcgcttgta cataagtgcc gttatctgcg cccccataaa ttctggctac tccttgatta 2716201 atagatacat attgtgaaaa tttagctttg atctcttctt gatttgattt ccctttgaat 2716261 gcggatcttt taagagattc actgaaaaag gtgactgctt tcgctttttc tcccagatca 2716321 tttgtaacag ttgtattaaa tgtatcgaca ctgtttttcg catttcccat aatttcctga 2716381 tccagctttc cgctggcgct tcggtaagag ctaaattcta atataagaat agggataatg 2716441 agaatcgcaa taaatgagac gattaatttc tttgaaatag acggtttctt cagccaattg 2716501 ataaaagtct tcatgtcact tgctccttca ggtttgatac agtatatatc ggctgcttaa 2716561 aaaagtttta aaataaaaaa tggaagaagt tctttttggc tgtcttctgc ctttttaact 2716621 ttcattgccc aagctctttg catatcttat aaaaaacaag gggggctaaa catgattatt 2716681 gtatcaggac aattgctccg tccccaggat attgaaaatt ggcagattga tcaagatctg 2716741 aatccgctct taaaagagat gattgagacg cctgttcagt ttgattatca ttcaattgct 2716801 gaactgatgt ttgagcttaa actgcggatg aatattgtag cagcggcaaa gacgctgcac 2716861 aaaagcgggg cgaagtttgc cactttttta aaaacatacg ggaatacaac gtattggagg 2716921 gtttcaccgg agggcgcctt ggagctgaaa tacagaatgc cgccttcaaa agcgattcgg 2716981 gacattgcag agaacggccc gttttatgcg tttgaatgcg caaccgcaat cgttatcatt 2717041 tattacttgg ccttaatcga tacaatcgga gaagataaat tcaatgccag ctttgacaga 2717101 attattttat atgactggca ttatgagaaa ttgccgatat atacggaaac aggacaccac 2717161 tttttccttg gagattgttt gtattttaag aatcctgaat ttgatccgca aaaggcgcaa 2717221 tggagaggcg aaaatgtgat actactgggg gaagataaat attttgccca tggtcttgga 2717281 atcttaaacg gaaagcaaat tattgataag ctgaattctt ttaggaaaaa aggagcctta 2717341 cagtcagcct accttctgtc tcaggcgacc agactggatg ttccgtctct tttccgcatc 2717401 gtccgctaaa aagccccatc gcctattttc cggacgatgg ggtttcaaat gcctttcgtt 2717461 ttcgatagaa gggggctgtg ccaaaatatt ggttcgcagc ccactccatt ttttcaaggt 2717521 catttcttgt cacgattgga tcctggctgc tccatttgat aaagcggaca aaatagtagc 2717581 ctttgatagg aaccattgta acttttgagt gaggccagcc ttcaaataca aactcaattt 2717641 tccctctttt tttataagaa tattgaagaa tgttcatatc tgtcacctca gtttatcaag 2717701 ttacgttcgg caaagctcgg tacgtttaca tccattgatt aactatccct catgcaggct 2717761 ttccggaaaa caaagggtga ggcgcgtgtc tctttccctc gctttttatt tcgcatatgg 2717821 acgaatgcca agcacgcctt cattcgataa agccgcagcg tgggcgggtg tgacaagccc 2717881 tccggctatc ggcgcttgtt cagcgatcat gcttttgtca taaaaaacag cctattatcc 2717941 catcattttg atatagcatg tccgggtgcg aggcccgtca aattcgcaga aataaatgcc 2718001 ctgccacgtt ccaagaataa gccggccgtt ttccacaatg acatgctgtg aagctccgac 2718061 cgtactcgac ttcatgtgtg cagctgtatt gccctccata tggcggtcca gctcatgttc 2718121 ccacggatat acctcatcaa accttctgag catatctttt ttgacgtccg gatcggcatt 2718181 ttcattaatt gtaatgcccg cagtcgtatg cggacagtaa atcagcgctg cgccgctcgt 2718241 tatacctgtt tcttgaagaa acgcttccac ctcccgggtg atatctatca tttcatctcg 2718301 tttggttgtt ttgatttgca gtgttttcag catttgtttc tcctttcgtt tgtccgctct 2718361 catcgcttaa ttcgttctgt gttctttttt ttcctgttaa accgctctca taaacccgat 2718421 aaaacaaaaa aactccagtc taaggctgga gtttagcacc atagatatat tcttgcttca 2718481 tacggcttta agagtactga tgtcatatgc ttgtgcggct ctgtttcaat atttgacaag 2718541 acgagtgcat ctgatgacaa tggcaatcca gagtgcctga acaacgccgg tgttcctgtc 2718601 agattggccg caatcagtgc agtatggctc tcgtttttcc gaagatatgc aaagatttgc 2718661 tgatcttccg gtaaaatgag ctcgtatgtc ccgttaataa aaacatcata tgtttggcgc 2718721 agcttgatca agcttttgta aaaatggtaa acggatgttt tatcgttttt ttgcgcctcg 2718781 gcattcagcc atttgtaatt ctcattgatt ccgatccacg gtttggcctc agaaaatccg 2718841 gcgtatggac cagcattcca ttgcatcggc gttcgcgaat tgtctcttcc ctttttccag 2718901 acaatcttca tcacatcctc gtgtgatgtg cctttcgctg tttttgtttc atacaggcgt 2718961 ttcaatgcga catcatcata gtcctcaata gatggaaaag ccacgttcgt catcccgagt 2719021 tcctgtccct gataaataaa cggtgtgcct ttcatgagaa aataaacagc ggaaagcgct 2719081 tttgcacttt ctttcaggta cactccgtcg tctccccaca cagaaactga acggggctgg 2719141 tcgtgattct ccataaacaa agcattccag ccgatccctt ccagactgtc ctgccagtca 2719201 gttaaaattc gtttaaatgc aacgatatca atactttcat tgatctctac atcccacagg 2719261 ccgagatgct caaattgaaa aatcatgctg aatatgccgt ttttttctcc agcccaatca 2719321 gctgcttctt ttgcagcgac gccgtttgct tcaccaactg tcataatcgg atagcgggaa 2719381 aatgtgtttt ccttcagctc tgttaacaaa tccataatgc cgtcagcatt catatgataa 2719441 ggaaaggaag ggacatagtc cagtcccttt ggattcggca tgtcaggaaa cccttctttt 2719501 ttcttaatat gcgtaatggc atccacccga aatccgtcaa ttcctttatc aagccaccaa 2719561 ttgatcatgt cataaacggc attcctcacc ttttcatttt cccaattcaa atcaggctgt 2719621 tttttatcaa aaaggtgcag ataatactgg cttgtctttt gatcatactc ccaagccggc 2719681 ccgccgaaaa tgctttccca attgttgggc gtttttccgt ttttgccgtc tttccaaata 2719741 taccagtcgc gcttttccga gtgtatggat gaacgggatt ctatgaacca tggatgttcg 2719801 tcgcttgtgt ggttcacaac gagatccata atcagcttca tatccagatc atgaatgtca 2719861 ccaagcagct catcaaaatc ttccatcgtg ccaaactcgc ttaatatgtt ttgataatcc 2719921 ctgatatcat agccattatc ggcattcggt gaatcataca gcgggcaaat ccatatgacg 2719981 tcagcgccca gctcttttat gtaagaaagc ttggttctga ttccttgaat atccccgatt 2720041 ccgtcgccat ttgaatcttt aaaactgcgg gggtaaattt ggtaaactac ggcttccttc 2720101 caccaagcct ttttcataca gccactcctt cccagtgtac cgttcttata tatcctatgt 2720161 agaaaaaggt ctttacagca ttgcttttta agaaatgact tgatgacaca aaaaacagcc 2720221 gtttgttccc cggctgtttt ttatcaaaaa tcagtttttt ttatttctac aaaacggatg 2720281 tggtgatctt cggcgtcgag gattttaaat tcacagccct ccgcgtgtat cacatcccct 2720341 gctttcagct ccattttttg cgttagaagc cagcctgcaa tcgtatcaat ttcttcattt 2720401 tcaatcgcaa tgtcgagaag gtcattcact tcgtctatta gcgcttttcc atccatcaca 2720461 taatggtgct cgcccttttt caggatgtgc ggtgtttcat cctgatcata ctcatcgcgg 2720521 atttccccga cgatttcctc gataatatcc tctacagtga caagccccgc cgttcccccg 2720581 tattcatcga caagaatcgc catgtgaatc cgctccttct gcatgcggat taaaagctgc 2720641 tgaacaggaa tgctttcaat gactctgata acgggcctca tgatttgatt cagctttatc 2720701 ggctggccga gaaaataagc tttaaacata tctttgctgt tgatgatccc taaaatatga 2720761 tccttgtcat ctttgatgac agggtagcgt gtataccgtt cattaatgat gtgatgaatt 2720821 gcctcttcaa gcgactgctc cagagagata accgcaattt ctgtccgcgg aatcataatc 2720881 tctctcgcta cccggttgtc aaattcaaaa atcttattta catagcggaa ttcagactga 2720941 ttgatttctc ccttttcata gctttcagaa aggatcagcc ttagttcctc ttcgctgatg 2721001 acaacctgat gctcctttac cgaatgaaag ccaaacaatt tcacaagaaa acttgcagag 2721061 ccgtttaatg ctttaataaa cgggtacgtg attttataaa accagatcag cggctttgca 2721121 atccataagc ttacagcttc agctttttga atagaaaccg ttttcggggc aagctccccc 2721181 atcaccacat gcaaaaaagt gacgatgata aatgcaacta caaatgtgac aatgtggtta 2721241 aacggttccg gtatgcctgt cattgtaaat aagggatgaa gaaaacgttc aaatgtaggt 2721301 tcaccaagcc acccaaggcc gagggctgta atcgtaatcc cgagctggca ggctgataaa 2721361 tactcgtcaa gattggagat gattttatgt gcggctagtg ctcggctgtc accgctttcg 2721421 atgagctgat tgatttttga acctctgatt ttgacgatcg caaattccgc tgcaacgaaa 2721481 acagccgtaa tgccaatcaa aacaaaaatg gcgatcaatt gtaaaataag caaaaaaagc 2721541 ccttaccata aatggtaagg ggccacctcc ttaacgttaa ttctcatcac gaccgtttaa 2721601 gaaaatcatc acaaaacgaa gtagttcaaa cagggaaacc agggcggcgg ccacatacgt 2721661 taaggcagca gcactcagca ctttatttac cccattttct tcattgtttc ggatgaatcc 2721721 ttctgacaca ataatctgct tcgcacgtga acttgcattg aattcgacag gcaatgtaat 2721781 cagctggaaa aagacagccg ctgaaaacag tatgatgcca agcccgatca aattcaggct 2721841 gccgagaagc atgcctccta agaaaagcaa aggagctaca ccggatgcaa aattcacgac 2721901 tgggaagatt ttatgtctca gcacaagcgc accatatgac tcctgatgct gcaaggcatg 2721961 tccgacttca tgggaagcta cggatatggc ggaaattgag cggccgtaat agaccggctc 2722021 agataaacgc accacccgtc ttgtcgggtc gtaatggtct gttaaagtgc ctcttaccgg 2722081 ttcgaccggc acgtcgtaaa gaccgtttat atctaaaatc cgtcttgccg tttctgcccc 2722141 tgtacgtccg cttgaggctt ccacttttga atatttttca aagttgctct ttactttaaa 2722201 ttgtgcccaa aacgacaatc ccaatgcggc tattgttaaa aatataaaca gcattttttc 2722261 atcatccttt gttcatgatc atttctctat tacgattatt ttaatgagtt ttctttctcg 2722321 tgtacagaaa tgcgcttttt cttccggctt ggagcacaca atccaatcag caaaaagaac 2722381 aggcctgctg aaaacaaata aaaggcgaaa ctgccggcca gttctttcag aaaatgaagc 2722441 caggagaagc ttccggaaaa gtgattatat gaattcaaat cgaaaataaa caaaatcacc 2722501 gcggatgccg ccagctgcgt accgattaaa accacgatcg ttctttgaaa gatcgtcatc 2722561 tttttcatcc tttttgtttt agtttatgga gaaatccggt tttatatgtt ttgtacattt 2722621 tttgaaaaac atcaccggaa gtgggacata ctgttagaaa aaagcacggg tgtgatggaa 2722681 gctatgaaag tgacgagtga ggaaaaggaa cagctgagca cagcaatcga ccgaatgaat 2722741 gaaggactgg acgcgtttat ccagctgtat aatgaatcgg aaattgatga accgcttatt 2722801 cagcttgatg atgatacagc cgagttaatg aagcaggccc gagatatgta cggccaggaa 2722861 aagctaaatg agaaattaaa tacaattatt aaacagattt tatccatctc agtatctgaa 2722921 gaaggagaaa aagaatgaaa tcaaatcgga tatttatttc atggctcagg tggccgttat 2722981 ttatccgaat cggggttatt attttatgtc tgattctttt gttcggccaa atcatttata 2723041 tacttgagcc taagcagttc acttcggtat tcgaaggtat ttggtgggct gtcgttacgg 2723101 tttctacagt cggttatgga gactatgtgc cgcacactcc gctgggacag gcagccggaa 2723161 tactgctgat tttgagcgga gcaagctttg tcacagcgta tttcgctacg ttatcagcgg 2723221 ccgcattcag cagacagcat cgctacattg aaggaaaagt tgcttacaaa ggccgggacc 2723281 acatcattct gatcgggtgg aatgaaaaaa caaaccggct tttgaaggac cttcagcttg 2723341 ccgccccttc caaaacagtc gtactaatcg atgaatcctt aacagaaggc ccgcttattg 2723401 aaaacgttca tttcatacgc gggcacgctg ccgatgatgg gacactgaaa cgggccaata 2723461 ttactgaagc ggaatcagtg atgattactg ccgatcagta taaaagtgaa actgatgctg 2723521 atatgctgtc agtgctgact cttttatctg ttaaaggtct taatcccctt gcttactgca 2723581 tcgtcgagat tttaactgac cgttttgtca ccaatgcgga acgggcaggc gcaaaccaaa 2723641 tcatcggaac ttcagaattt atcagccggg cgatgctgca gcattaccaa gtcaagttac 2723701 ggccgtctaa acagcagaac ggaatcaagc tgacacttga tcagcatgtg gagcttcttg 2723761 ctgttcctga cgaactaaag ggagcggctt acaaaacctg tgttctctat ttccttgatc 2723821 acaacacaac aattataggc atacaaaaaa aggaggggcc gatgctttcc cctcctctta 2723881 catacaaggt gctcgaaaca gatcaattcc ttgccatcta gtgtaacaga acatcctcca 2723941 attctttcac gagagaggcg ccgatatcca aaaatgccgg atcaatttcc gcgtcccgcc 2724001 tttccggttc ggaaaattga ttaaacagtg attggaaagg ccctccctcg gcgtgatcgt 2724061 caacatccgc ctgaaacacc tgtctcagca taaatggcgt tccgatccgg acggccgccc 2724121 ctcgttcatc gagactgccc tgtaccgcat tgacgggaat tcttaaaaat aaatagccgt 2724181 ctctatcatc aattttataa tcaaagtagc catgatcgta ttcccagccg ccgtttatca 2724241 cataaccgag cggcttcatc acttgttcca gttcttgaag cagaaaagac tgcccatcta 2724301 tcgcggaagg tattggtatc atcagaatgc cccttttttc acttatcctg tcccgccgaa 2724361 caagacttca ttcagaggcg cctacatgga aatcgttgtt tctttcgcgc ggccaacagg 2724421 aaagaaagcg cattcaatta agaagtaaac agccattgcc gctgcaagcc atacagctga 2724481 atcccaagac acataaacaa ccgttgcata gagtcctaat ttagtgaaaa gagtatgggt 2724541 tcgttttaaa tgcaaaatcc gatgtaccgc atcggtaaaa agggcaagcg gcaaaccaat 2724601 gagaagaaag gagtggatga aaaaatgtga cagcgtgccg ccaaagcttg aagaaaaccc 2724661 tgtatacacg gcatcaaagg agataaggaa acttaaaata gctgcagaaa aaccggcaat 2724721 gatgagatgt ttaaccaatt gtttcatgaa catcagcacc tttctgattt tataaaaagc 2724781 cgaccggcaa atgccagtca gctttctcac attaatcttc cagacgtttt tcaagctctg 2724841 cttttttctc ttcaaagcca ggtttgccga gtaacgcaaa catattgact ttatacgctt 2724901 ctacaccagg ctggtcaaac ggattgacgc caaggaggta accgctcatc gcgcaggctt 2724961 tttcgaagaa atatacaagg tatccaaaag tatatgcatt cagctcagga atgttaacga 2725021 ttaagttcgg aacatttccg tctgtatggg caagcattgt accttggaat gcttttttgt 2725081 taacgaaatc aacagtttta ccggctaaat agttcaagcc gtcaagatcg ttatccgctt 2725141 cctcaattgt cagttcatgt ttaggcttct ctacgttcag gaccgtttcg aataaatctc 2725201 tgcggccttc ttgtacatac tggcctaaag aatgaaggtc tgttgaatag ttcgctgaag 2725261 aaggataaat gcccttctca tctttccctt cgctttctcc gaacagctgc ttccaccatt 2725321 ccgcaaagta ttgaagcgcc ggttcgtagt tgatgagcat ttcaattgtt ttgcccttat 2725381 tataaaggac attgcgaaca accgcatatt ggtatgctgg gttatcttcc agttcagatg 2725441 ttgcaaaatc tttgctcgca tccagggcgc ctttcatcat gtcgtcaatg ttgacgccgc 2725501 tgacagcaat cggcaagaga cctacagctg ttaaaactga ataacggccg ccgacatcgt 2725561 caggaattac gaatgattca aagccttctt cgttagaaag cgtttttaat gcgccgcgct 2725621 ctttatcagt tgttgcataa atccgcgctt tcgcttcttc tttaccgtat ttctcttcaa 2725681 gaagcttgcg gaaaatacgg aaagcgattg caggttcagt tgtcgtacct gatttagaaa 2725741 tcacattaat agagaagtca acatcttcaa gaagatccat gacgtctctc atataagatg 2725801 aactgatgtt gttcccgata aaaatgactt gcggattgcc gcgttttgct tttggcaaag 2725861 tgttataaaa cgcgtgattc agcgcttcaa tcgctgcccg cgctccaaga taagaaccgc 2725921 cgatgccgac aacaagcaag acatcagagt cagatttgat tttttccgcg ctttttttga 2725981 tgcgcgcgaa ttcttcttta tcataatgtt cagggaggtc cacccagcct agaaaatcgc 2726041 tgcccgcgcc tgttttctca tggatattat ggtgtgctgt ttttacaaag tcccgcaggt 2726101 atgtaagttc atgttcgttg aagaaagtca acgcttttga gtagtcaaag cgtacatgcg 2726161 tcattgcttg tccctccata acggtataat gttttcatct ttcactttat atgaacttat 2726221 ctgtgaaatc aagtcaagaa gaaagggcgg aatgactgga ttccgccctt tgggtttata 2726281 gagacgcgcg aaggatggca agcacgtcat ctttgttcag tttttggaag ttgccgaagc 2726341 cgccgtgttc catttccttg gctgcgatat cagcaatcag ctcaagcttt tcttctccaa 2726401 tattgtaatc agcaagacga gaaggtgcac cgaggcttgt ccagaacgca gacagtttat 2726461 cgattccttc aagcgcaatt tctttatctg ttttgccttc agtatcaatg tcaaacatgt 2726521 tgagcataag gtttttaaaa cggcctacat ttgtatcaag cgtgtatctc atccaatttg 2726581 ggaacagtat tgccaaaccg cccgcgtgcg gaatatcata tacagctgaa acagcgtgtt 2726641 ccattgtatg agaagcccag tcaccgaagt atcccatttg gagcgtgccg tttaaagcaa 2726701 tagtaccagc atacaaaatc gtttcacgaa gttcgtagtt ttccagatct tcaagaagct 2726761 taggagctgt ttcgatgacc gtctgcaaaa cagcaaagca cattctatcc tgaagcggcg 2726821 tgttttcaac attatggaag tattgttcga atacgtggct catcatgtca accatgccgt 2726881 atactgtttg attttctgga acggtgaacg tattttcagg gtctaaaata gagaaacgcg 2726941 gatgagtgac attgctgccc catacaaatt tctcgtttgt ttcccagttt gtaatcacgg 2727001 aatcagggtt catttcagac cctgttgcag caagagttaa aacagtgcca aacggcagcg 2727061 catcctccgc tgttactttt ttgctgaaaa tatcccaagc gtcaccgtca tatttgacgc 2727121 cagctgcgat tgcctttgta cagtcaatca cactgcctcc gccgacagca agcagaaaat 2727181 caatgtcatg ctctctgcaa agtcctatgc ctttttccac tgtcgcaaga cgcgggtttg 2727241 gctctacacc tgacagctca tgaacaacag cgccctcttc ttttaaaatg cctgtgactt 2727301 gatcataaag gccgttgcgt ttaatgctgc cgcccccgta aacaagcagt acattcttgc 2727361 cgtatcgttt gaattctttt cttaattgtt caagctgacc ttttccaaaa atcagctttg 2727421 tcggattata ataagtgaaa ttttccatag taaaacctcc aaatgatgct ggtaaaaaac 2727481 agattttcca ttgtaacata agttgacaaa aaagaaaaag ggaagcagcc aaacggctat 2727541 ttcccctttt tttatagtga tgctttcaaa attgacagca catcttcttt gttgagtgat 2727601 ttaaattggc cgaatgtacc gttagccatt gccttgtcag cgattgtgtc aagctgctca 2727661 tcattaatat cataatcagc aagacggttc ggagcgccaa gacttgtcca gaatgcggac 2727721 agcttatcga taccttcaag ggcaatttct tcatccgttt tacctgcttc ttcaacatca 2727781 aacacgcgaa ctgcaagctg tttcatgcgg gcagggtttt cagacaatgt gtgtctcatc 2727841 caattcggga acagaatcgc cagtccgccg gcatgcggaa tatcataaac ggctgatact 2727901 gcatgttcaa tattatgagt agcccaatcc cctcttgccc ccatagaaag catgccgttt 2727961 aatgcgattg ttcctgtgta caggatcgtc tcacgcaatt cgtaattttc gagatcattg 2728021 atcagcttag gcgctgtttc aatgactgta cgcaaaagtg attcacacat gcggtcctga 2728081 tacggcgtgt ttgatacatg atggaagtat tgttcgaata cgtggctcat catgtcaacc 2728141 atcccgtaga tcgtgtggtt tttaggtacg gtgaatgtat tcaccggatc aagaatcgag 2728201 aatttaggga atacgagcgg gctgccccag ccgtattttt cttttgtttc ccagtttgta 2728261 ataacagatc ctgagttcat ttctgaacca gttgcagcga gagtcaatac cgttccgaat 2728321 ggcaaagcat cttttggctg atgctttttc gtaacgatat cccacgcatc accatcatac 2728381 ttcgctcctg cggcaatcgc ttttgtacag tcgattacgc ttccgcctcc gacagccagc 2728441 aagaaatcaa tgttttgttc tttacagatg gcaacacctt tattaacagt cgacacacga 2728501 ggattcggtt ccacacctgc taattcatgc acggtcgctc cggctttatt cagctgttca 2728561 atcacttgat catacaggcc gctgcgttta atgctgccgc ctccgtacac aagcaatacg 2728621 ttttttccgt aaggtttgag ttcctccgga agtctttcca cttcgccgcg cccgaaaatt 2728681 aatttggtcg gattccagta tgtaaagttt tgcatgacat ctcctcctta gattttttat 2728741 tatgcagaat gtcctcacca catgtaaagc aatcagctct caccgatcag cataccagat 2728801 ggttttattt tgcaaggtgc tgggaaagaa gctgatataa gcgagggcag gccagcttcc 2728861 ctcatatgga gaatgcatgt atagattctc caatatgtca caatctataa ctgttttaat 2728921 aattcatgga ggaggttgca aaacatgagt accattcaaa gaatttgtct tgtattaacc 2728981 atcattggcg ccattaactg gggactgatc ggatttttcc aatttgactt agtagcggct 2729041 atcttcggcg gccaagggtc agctctttcc cgaatcattt acggacttgt cggaatcgcc 2729101 ggcttaatca acctcggtct gctatttaag ccaaacgagg aaagatcacg tgaagaagca 2729161 gcaaatcctg aaatgcgata ggatatcaat cacgctgaaa taggattttg catgaaatca 2729221 aaagcaccga acattcctgt ccggtgcttt tttcatgctt attttttgat aaggtctttg 2729281 cggttggaca tttcgatcca ctcttcaagc ttatctttta atgtgttgaa accttgtggt 2729341 gtagaagctt cttcgcttac ttgagcagct ttaggttttc ttggtttgct ttcttttttc 2729401 tcaggcgcag cttgtgtcgc acgaattgaa aggctgattt tgcctttttc ttcatcaaca 2729461 gcaagtactt ttacttgtac ttcgtcgcca actgaaaggt gctcgttgat atcttttacg 2729521 aaaccgtgag tcacttcaga aatgtgtact aaaccttgag tttcttcatc taatgcaaca 2729581 aacgcaccat acgcttgtaa tcctgtaact ttaccagtgt aaacactgcc cacttcaaat 2729641 tttgctgcca ttcataacaa ctcctaagtt aaattaaata tctgtttata cgcaatttaa 2729701 aattatatca cacatgtctt atttccgcaa agaaaacttt tttataaaaa atcaggttta 2729761 tgcacagcaa aaagggggta aactgaaaat accaaaggct ttctagtatt cccccctttt 2729821 attggatgcg aacaaaaggt tcgtatcttt ttttatgttg ttttgtgcag gaagcgtttc 2729881 attctgacta acgcttcttg aagctgttca atcgaggttg cgtatgaaca acggatatat 2729941 ccctcaccgc tcggaccaaa cacacttcca ggaacaactg ccactttttc ctgcgtcagt 2730001 agctcctcgg caaactgttc tgaactcatt cccatgcttt tgatagatgg aaaagcatag 2730061 aaagcgccgc ccggatgatg acagctgaga ccgatttcat tgagcgattc tacaaacaga 2730121 ttccgtcttc ttcgatagct ttttttcatt ttttctacgt cttccatgcc gttcttcagg 2730181 ccttcaaggg cggcaaactg cgccattgcg ggcgcgcaca tcatcgcata ctgatgaatt 2730241 ttaagcatgg catcccgaag caaggatggt gccgcggcaa aaccgagcct ccagcccgtc 2730301 attgcaaatg cttttgaaaa gcctgagatg actaccgtcc gttccttcat tcccggtaat 2730361 gccgctatac ttgtaaattc ctcatcatat gtcagctccg cgtagatctc gtcggctaag 2730421 acgatgacat catgtttttt ggcaaactca gcaatctcat tcagctcttc cttcgaataa 2730481 accgaacctg tcggattcga tggtgagcag atgagaatgg cctttgtttt ttcagtgact 2730541 gccgcttcaa aatcagcagc cgttgcttta aatcctttgt ctgccgttgt atgaacgtga 2730601 accgggatac cgcctgccaa agaaacaagc gcatcgtacg caacaaaaca cggctcagga 2730661 atgatgactt cctcacctgg attcacaatg gcgcggatcg caatatccaa agcctgactt 2730721 gcccccactg tcacaatcag ctcattatct ggcgagtagc taaggtcaaa cctgttgctc 2730781 aaataacggc tgatttcctc ccgcaatgag tataaacccg cattggccgt gtatgacgta 2730841 tatccttgtt caagagagag aatgcttgct tcgcggacat tccatgcggt aacaaaatca 2730901 ggctcgccga cgcctaaaga aatgacgcct tccatcgttg ccgccaaatc aaagaatttg 2730961 cggatgccgg atggttttat ttgttgtaca tagtctgata aatacgaagt catttacggt 2731021 gacaccacga ttcttttgtc gtcgtctcct gtttcaaaca ctttgccgtc atgcttgtat 2731081 tttttcagga taaaatgggt tgtcgtagat acaactgaat caagcgttga gagtttatcc 2731141 gaaacaaaac gcgctacgtc agacatcgaa ttgccgcgaa tcacgacaga caaatcgtat 2731201 acgcctgaca tcaggtaaac tgattcaacc tcttggaatc ggtaaatccg ttccgccact 2731261 tcatcaaaac cgacgccccg cttcggcgtt actttgacgt caatcatggc cgtaacgccc 2731321 tcatgtccgt cgacttttcg ccagtcaatc atagcggaat aatcgataat aaccttttct 2731381 ttctccagtt tgtcaataat tgttttcact tcatttacag ggatgcccgc catctttgcg 2731441 attgtttcta aatcggcgcg gctgttttcg tctaaaattt ctaatatttc tgtttctttt 2731501 tctgtcaatt tcatttgatt cacacctttg caatgtcaag aaatctcatg acattatatc 2731561 acgttttttg acgaatgcta agaaaaaacg aggagaaact tccgctagaa ttgacaattt 2731621 cagggcataa tacaaccatc aaaaaaaggg agtgacacag aatggaggcg gtttcaccaa 2731681 taaggcggtt tacggtcgat ggagtcaatg tatactacga acattatcaa aatcccggca 2731741 ggcaaacgct ggtctgcgta cacggttttt tatcatctgc attcagcttc agaaaagtaa 2731801 ttcctctcct tcgggacaag tacgacatca tcgcgcttga tttgcctcct ttcggccaat 2731861 ctgaaaaatc aagaacgttt atctatacct atcaaaacct tgctaagctt gtcattggga 2731921 ttttggagca cttgcaagtg aaacaggctg tgcttgtcgg gcattctatg ggcgggcaga 2731981 tatcgctgtc tgctgctctc caaaaacctg agcttttttc aaaggttgtg ctgctttgca 2732041 gttcagggta tttaaaacgt tcacacccga cgattatttt cgggacccat atcccgtatt 2732101 ttcatcttta catcaaacgc tggctctcga aagaaggcgt gatgaaaaat ttattaaatg 2732161 tggtgcatga caaatcgctg attgatgagg agatgattga cggctatggc agaccgtttc 2732221 aggacgagca gattttcaaa gccatgacaa ggtttatccg ccacagagaa ggagatttag 2732281 aacccgagca attgaagaaa atgaacaagc ctgctctatt gatttggggc gaggaggatc 2732341 gaattgtccc aatggagatc ggtaaacggc tgcacgcaga tttgcctaat tccgtgctgt 2732401 actcacttgg ccagaccgga catctggtgc ctgaagaacg gcctgaactt atttctgaac 2732461 acattgctga ttttatcaaa taacaaaaaa accggtgctg aaccggtttt tttaaggcgt 2732521 gcaggagctg ctgtttttaa tgaataaaag ctggccagcc acttcccggc agctggcgat 2732581 cggcagcgtt tgttcaaaag aagtttcaaa tatttgctga atgcttttcg ccagcaagtc 2732641 gggatcgttt tcatcataga ctgcctgcac gacatcaaca gcctccgttt cgtaaaactc 2732701 ttctccatat ttaaacgggt cccatttggc aatgatctta atcatttccc tgaccgcatg 2732761 actttcttcc atattcatca ccgcttataa taaaatttgc agttctatct tatcatagtg 2732821 aagcttagaa gaataaacat acatgagggg gtaacagaat gaactttgat aaacgagaag 2732881 aacgccttgg cacccaatcg gtcaaatggg ataaaacagg cgaattattt ggcgtgacag 2732941 acgccctccc gatgtgggtg gcagatatgg attttcgcgc cccggaagcg ataactgaag 2733001 cgttaaaaga gcgtcttgac cacggtattt ttggttatac aactccagat caaaaaacga 2733061 aggatgctgt gtgcggatgg atgcaaaaca ggcacggctg gaaggtaaat ccggaaagca 2733121 tcacattcag ccccggcgtt gtaacagctt tgagcatggc ggtacaagct tttacggagc 2733181 cgggcgatca agtagttgtt cagcctccag tttatacgcc tttttaccat atggtggaga 2733241 aaaacggccg gcacatttta cataatccgc tgctagaaaa agacggcgca tatgcaatcg 2733301 attttgaaga tttggagaca aagcttagtg acccaagcgt tacattgttt attttatgca 2733361 atcctcataa cccttctggg cgttcatgga gccgggaaga tttactgaag ctaggcgaat 2733421 tgtgccttga gcatggcgtc acagttgtat cggatgaaat ccattccgat ttaatgctgt 2733481 acggacataa acacacgccg ttcgcttcgc tctctgacga tttcgctgat atttccgtga 2733541 catgtgctgc tccaagcaaa acatttaata tcgccggatt gcaggcttca gcgatcatta 2733601 ttccggatcg cctgaagcgc gccaagtttt ccgcaagcct tcagcgaaat ggtttaggcg 2733661 gactgaacgc gtttgccgtc actgcaatcg aagccgcgta ttcaaaaggc ggaccgtggc 2733721 ttgatgaatt gatcacttac attgagaaaa acatgaacga agcggaagcc tttttgagca 2733781 ccgagctgcc aaaggtcaaa atgatgaagc cggatgcatc atacttgatt tggctcgact 2733841 tcagcgctta cggcttgtcc gatgcagagc ttcagcaaag aatgctaaaa aaaggaaaag 2733901 ttattttaga gcccgggacg aaatacgggc ctggcggaga aggatttatg cgcctgaacg 2733961 ccggatgctc tcttgcaacc ctgcaggacg gcctgcgccg catcaaagcc gcattatcgt 2734021 aaatatagct gtaaacgcct ttacgtcttc atttgtaaag gcgttcttaa taaaggaatt 2734081 ttatatttta cttctaatat ttagtgttat aatagattca tattttatac gaaaggattt 2734141 cacacgaatg gaaattctaa aagactatct tctgcacatc tgctttattt tgtttcctat 2734201 tcttctttac caagtgtttt ggcttggaaa acctgcgatt cttgtgccaa aaataaacag 2734261 cggtttggtc acgctcttcg cctgcggcgc ctccgtttta tgcattattt tcccgattca 2734321 tgaaatggac tacatacaat acggccttca gatgattccc gttatcattt gtttatttta 2734381 cattagtacc gcttccggac ttacagtcgc cgcatctgtc ctatgttttg aactgctttt 2734441 ttacgaacct tccgcaatgt ttgttttcac tttgctgcct tttcttatca ttatcccaat 2734501 cttatttcag aaaaaatggc cattcatgtc caaagcgaaa aaactgctgc tgtctttatt 2734561 gatcagctgc gtggagattt tcctattttt cgcctcaagc tggattcttt ccgccttgaa 2734621 tattttaaat tttcaaaaat caggaatttt cgtttacgag gcggcagtct cagggctttt 2734681 ccgctccagt gttcttctat taagcatcta tattatcgaa agcatcgccg aaaatatcgc 2734741 cctgcgttca cagcttatcc attctgaaaa aatgacgatt gtgagtgaac tggcagcgag 2734801 cgtcgcccat gaggtcagga atccgctgac agttgtccgc gggtttgtcc agctgctttt 2734861 taatgacgaa accctacaaa acaagtcgag tgcggattac aaaaagcttg tactgtcaga 2734921 gcttgaccgg gcgcaaggca ttatcacaaa ctatctcgat atggccaaac agcaattata 2734981 cgaaaaagag gtttttgacc tatctgccct tatcaaagag acaagctccc ttatggtgtc 2735041 gtacgccaat tacaagtcag taaccgtcga ggctgaaaca gaaccggacc ttttgatata 2735101 cggagacgca acaaagctga agcaggctgt catcaacctg atgaaaaaca gtattgaagc 2735161 ggttcctcac gggaagggga tgatccacat atcagccaaa agaaacggcc atacgatcat 2735221 gattaacatc acagacaatg gggtcgggat gacagaccat caaatgcaaa aactcggcga 2735281 accttattat tccttaaaaa cgaacggaac gggactcggc ctcaccgtaa ccttttccat 2735341 tattgaacat catcacggga ccatttcatt taacagcagc ttccaaaaag gcactacggt 2735401 gaccattaag cttcccgctg atcttcctca ctagcaaatc gattggaact ttaatagaat 2735461 aaatgcgagg tgatgacaga tgagcacgtt tgagacaggc tctatcgtta aaggatttta 2735521 caaaacaggt gtatacatag gagaaatcac ggcttgcagg ccgcagcatt atttagtgaa 2735581 agtgaaagcg gttcttaccc atcccgctca gggagacctt catcatccaa aacaggcgga 2735641 tgtgccattt tttcatgaga gaaaagcgct cgcatatggt gaacagacca atatccccca 2735701 ccatatggtg aagccttatg acggtgaagt gccggattat accgaatctc tgcgggaggc 2735761 gacagcacag atgagagcca aattgaatga ggatggttcg gagtgggcaa agcgctccct 2735821 tcataatctg gacattttag aaaaagaata ttttaaccgg ccataaccca gtctgacaaa 2735881 agattgggtt ttttacgtcg cgcgcttcaa cagttcggtt aaatcgattc tctcgccgat 2735941 tgtgggcggt tttggctttt cgagatactg cttatcctgc tcaacaagct taaaaagttt 2736001 atatgctgtg agagcatcat caagcgcttt atgatgggtg ccggttccgg aatctccata 2736061 ctcttcggca gctttccata aacccgtcaa tgtccggtct ccaaaaaagt ttttgtattc 2736121 aagcgataaa tctctcattt ctcccttaaa cgggaaaggg atatggttaa acatacagtt 2736181 ttgcttcagc actttcatat ccatgtttcc ccacgtaata attgtgctgt ttttctcagg 2736241 atccagctcg tttagtttac ggatgaaatc ctcgaatctc attccttcgt ctacctgttt 2736301 ttgggttatt tttaaaaatg atttgcagcg tttcgtaagc ttcgggaact ttttcggtct 2736361 aacatagcta gaaaacgtct caaccacttc atcatcaatc gactttacaa ttccggcttc 2736421 aatgatttcc gggaagaagt tttgaggact gtactttcca tcaggcattg taaattcgaa 2736481 atcaataatg agtaagctgt ttgtcgtcac cttttacacc tgcctttcct ccgatcagaa 2736541 aatgctatct ttatagtata tcaattcccc ttctcgacat ttcttcattt tctaaaaata 2736601 atgaattttc ccagccgctt cgtttctttt aaattgtgaa tcgtttcttt ataattagta 2736661 aggaacccga aataataaga aggtgatgtt atttctatcc gtaagaaaaa ctttgtcatt 2736721 gtgtggctgg cgaacttttt tgtctccgct agcacaacga tgatcgttcc ttttctctcc 2736781 ttatacattg agacgctcag ctctttttca aacggctttg tgcaaaggtg gagcggctat 2736841 gtgttcggca ttacatttct catggcgttt ttggtatccc cgttttgggg acggttcgga 2736901 gacaaacgcg gatacaagaa aatccttatg gcaaccggaa caggcattgc cctcagcatt 2736961 ttcttcatgg gctttgttac atcggtgtac caattgtttt ttctgcgtat ggcaatgggt 2737021 cttgtaaccg gattcatccc gacatctctt gcgatgattt cggcacagac tccgaagagc 2737081 tcagctggca aaacactcgg cacgctgcaa atggggcaag tgtccggaag cttgttcggc 2737141 ccgcttttgg gaggcatgct tgctgatcgt ttcggcttta cgtatacctt ttttatcaca 2737201 tcctttgtga ttttctcgtc tgttcttctc gtgttatttg gtgtcaaaga aaagcatctt 2737261 gcagagaaaa cagccaaacg tacgtcttac tcgagaaaag aagtgctctc ctatattttt 2737321 caccatccgg cgctgtgggt catgatgctg ttaaccatgc tgattcaaac aggcaatttc 2737381 agtatccagc ccctgctcgc tttatatgta aatgagctgc acggacctgt caatcttgcc 2737441 tttttctccg gcatggcatt ttcagcaacg gggctcggaa gtttgctgct ggctagaaaa 2737501 tggggtgatc tgggcgaccg ctacggccac cgccgcattt taatcggact tttgctcgcc 2737561 gcctctttct tttttattcc gcaggcgctc gcgtcctcac tcagcgtgct ccttgttttc 2737621 agatttttat tcggaatggc gatgggcggt ttgctgccat gcattacggc agcgatccgc 2737681 gttcaggctc ccggcagcat tcaaggtgaa gttctcggct acaatgtcag ctttcgcttt 2737741 ttaggaaacg tgctcgggcc tctgctcggc ggaatcatat cgagccattt taccatttcg 2737801 gccacctttt acgtcacggc gtttctcttt ttcgccggcg cctgcatgct ttggatcatg 2737861 cagaaacttc ggaaagattc ttatgccaaa gcaagctgat tccgagaaaa aactaaggaa 2737921 tcttctaaat ttaaccttct cgtaatctca aaagaatggt acgatatggc tagaatttag 2737981 gagaaaagag agtgaccatg ttacgaaaaa taatcggatg gattttgctc ctttgcataa 2738041 tcccattgtt tgcatttaca gttatcgctt ccggaaaaga agtaaaacaa atgaagtccc 2738101 tggatcaggt gcttgataaa aatattgatc tgaaagatat cagccttgtt cagaacagct 2738161 acatgtatga cagggacggc tcccttgtct cggaaatcgt cagcgaccac gaaaaccgtg 2738221 tgctcgttcc atttaacaag attcccgagg aagtcaaaca gattttctta acatctgagg 2738281 accgccattt ttacgagcat aaaggctttg actttatggg aatggtgcgg gctactgctt 2738341 ctaacgtaaa agacaagaaa attgaccagg gtgccagcac catcacacag cagctttcaa 2738401 gaaacttgta tttgagccac gaacgctcct tcagccgcaa gctgacagag ctcgcgtatt 2738461 cctatcagct ggagaaaaaa tatacgaaaa atgaaattct tgaagcttac ttaaatacca 2738521 tttatttcaa caacggtgtt tacggcgtcg gttcagcagc tcaattctat ttcagcaaac 2738581 cgctgaaatc tctcacagtg ggagaaatgg cttttatctg tgctatacct aataacccta 2738641 cattatatga tcctctcaag cattttgact acacgaaaag ccgtcaagaa cgtttactta 2738701 aagggctaaa agatgccggg gtcattacgg acaaagagct gaaaaaagcc gtaaaacaaa 2738761 aaatcaaact ggatgttgaa aaaagagaag acaaatatcc tgactacgtt tcctacgtca 2738821 atgatgaatt cactcagctg gtgtctgaat cagaaggctt tgataaacgc cttcaaaaag 2738881 catcaggaaa acaaaaagaa aagatcgaga acgagctgtc cgcaagagtc agcacgctga 2738941 tgaaagacgg agtgaaaatt tatactgcac ttgatccgta catgcaaaat caagttgtgg 2739001 cacaaatgaa ttccaagctc ccgtatgcgg acgtacaggg cggagcggct gtgattaatc 2739061 accagacgca tcaaatcatt gctctatccg gcgggaaaaa ctatcaaaaa tatgacttta 2739121 accgcgccta ccaggcgtac aggcagccgg gttcatccat taagccgctt cttgattacg 2739181 gcccttatat tgaacagacc ggcgcgacaa caagcagcac cattgatgcc agcaagtttt 2739241 gcagcaaaga ctactgtccg caaaactaca ataaccgcac ttacggcaca gtgacgcttg 2739301 atacggcgtt taaaaattca tataataccc cggctattag aatgctcgac cgcgtcggca 2739361 tccaaaaggc attcagttat attgagccgt atcattttgc caaacttgtc gacagtgact 2739421 atcttcttcc ggcggcgctt ggcggattta caaacggcat gacgcctctt gagatgacaa 2739481 aggcttatac gacattcgga aacagcggaa gctatacgcc gagccatgcg attacaaagg 2739541 tgacagacct taaaggaaaa acactttata aatggaatga taaagcgact caaatattca 2739601 gcgtccgcac gaacatgcag ctgaaaaaac tgatgtcttc cgttgtgaaa agcggaacag 2739661 ggaaaaaagc atatttcaat gcgccttaca tcggcggtaa aaccggaaca tcaaatgatt 2739721 atcacgatat gtggtttgtc ggcctgactg atacgtatac aatgggtgtc tgggtcggaa 2739781 aggatacacc gaccagcgtt gaatatcttc acagcatcag ccctcagctt tccatctgga 2739841 aaggaacgct gcaagcggct tattaaagga tcggagggga tatggagtga cttcagaaca 2739901 aattccaaat cgcgttttgc tgtttgacgg tgtctgcaat ttatgcaatg gcgccgtgca 2739961 gtttatcatt aaacgtgatc cggacggatt gatttctttc acatcgctgc agtcggaaac 2740021 aggacagagc ctgctgaaaa aaagcgggct tccgactgat cggtttgaca gctttgtctt 2740081 tattgaagac ggccaagtgt acacaaagtc aactgcagcc attaaggttt tcaggcatct 2740141 gcgaggccca tggcggctct tcgtcctttt tttcgcagtg ccgaagcctg tcagagatat 2740201 ggtctattct ttcattgcca aaaaccgcta taagtggttt ggcaaaaaaa atgaatgtat 2740261 gctcccctcc ccttccatta aaaaaagatt tttaccgtaa ataaaaaatg gctaggaagc 2740321 tagccatcac agattgttga caaaatccta aaacggcttc gttttaggat tttgtcatct 2740381 attcagcgtg attgaaaact tttgaagttg tgaaacggcg gaaacctgag aatctagccg 2740441 ccgtttcatt gcgtacagag cacgaagcgc aaatctgacc accaaacgct gaaatggcta 2740501 gcttacacag gtaagctagc cattatgcta ttataaagct tgataaatat gaacagaata 2740561 ccgataacaa aggtaaacca aaacagcagt tccaatagaa tgaatccaac taatgacatg 2740621 agagaaagcg tcgaataaat ccggtatacg gtaaacacaa agtaagcgag cgtgacgacc 2740681 gcaaaccaga tcacaatcca aatgacattt tgcaagagca caaaggataa aatcccgccg 2740741 cccaaataaa tcatggaacc cattctgagt tttttcaggt tgttcccttc cggatcatta 2740801 gcaaaaaaca gcaatgacag ctcggtcacg gtatttgcaa ttaatttcag agcggacaga 2740861 accataaaat ataaaagtgc aaaggcagca aataacgcaa gcctgattcc tttctctgaa 2740921 aaataatcga gcattccatc atacattcca aatgaagaca gcatcttcaa cgcataaagt 2740981 gaagttgaga tggataagga cgaactaaaa agcaggatcg caatcagcgg aaaatatcct 2741041 gtcaaataag tatttttcat ataaaaaagt ccctttctat aatctacctc atttattatg 2741101 gaggacttaa aacacattga caagataaat tattccattt tttctccttt ttacgaatta 2741161 cgggcccaaa tcttcacaaa gcagcatttt gagagtaaag tagtacgcag gaatcataaa 2741221 acgtaaggaa gttttatatg aaaaaaacat taaaactgca aaccagactc accatatttg 2741281 tttgtatcgt tgtattaatc gcattgctca ttacgttttt tacagtcggt gcccaaacca 2741341 ccaaacgaat tagagatcag gaaaaggcca ctgcgctgca gactgctgaa atggtagctg 2741401 aagcgccgat gacagccgct gctttagaaa gcggaaaaaa acaaaaggaa ctgcagagct 2741461 acacaaagcg ggttcagaaa attaccggca cggaatttgt tgtcgtcatg gatatgaacg 2741521 gtatccgcaa aactcatcct gacccgagca aaatcggaaa aaaattcaga ggcggtgatg 2741581 agtccgaggt attaaaaggg catgtccata tcagcacagc ctctggcacg ctcgggaaat 2741641 cgcagagagc gttcgtccct gtctacgcgg agaatggaaa acaggtcggt gcagtcgcgg 2741701 tcggcatcac cgtaaatgaa attgatgaag tgatcagcca tagcttacgg ccgctttact 2741761 ttattatttg cgtcagcatc ttcgtcggtg tgatcggagc cgttatcgtc gcccgtacag 2741821 tgaaaaatat catgtacgga cttgaacctt atgaaattgc gactctgctt gaagaacgga 2741881 gcgcgatgct ggaatcgacg aaggaaggaa tactcgctgt cgatgaacat ggcaaaatta 2741941 aacttgccaa cgcggaagca aaacgcctat tcgtcaaaat gggcatcaac acaaatccca 2742001 ttgatcagga tgtagatgac atcttgccga aaagccgctt gaaaaaggtc attgagacaa 2742061 aaaaacctct tcaagacaga gacgtccgca ttaacgggct ggagcttgtg tttaatgaag 2742121 ttcctatcca gctgaaagga caaactgtcg gagcgattgc aacattccgc gacaagaccg 2742181 aggtaaaaca tttagctgaa cagctttccg gtgttaaaat gtatgcaaac gcactgagag 2742241 cgcagtctca tgaatttatg aacaaactgc atgtgatatt aggtctcgtc cagctgaaag 2742301 agtatgatga tcttggagat tatattaaag atatagccat acagcaaaaa tcagaaacaa 2742361 gtgaaattat aaatgatgtc aaaagctccg tactggccgg ttttctgctt ggaaagcaaa 2742421 gctttatacg tgagcagggc gcaaatcttg atattgaatg caacggtgtc atcccgaacg 2742481 cggcagaccc ttctgtcatc catgaactta ttacaatcat cggaaatctc atcaacaatg 2742541 gcttagatgc cgttgccgat atgccgaaaa aacaaatcac catgtccatg cgcttccata 2742601 acagcatact tgatattgaa attaccgata ctggagcagg catgtctgaa gaagaccaag 2742661 ccaaagtatt tgaacaaggc tattcaacaa agggcaaaaa ccggggattc ggcctttatt 2742721 tcacacagca aagcatcgaa aatttaaaag gccaaatgat cctcacaagc gaaaagaatg 2742781 aaggaacgac attcagtatt cgcatcccgt acgaaccgaa ggaggaaaat catgattaat 2742841 gtactaatag ttgaagatga ccccatggtg ggtgaattaa ataaacgata cttaagccaa 2742901 atagatggct ttcagctgaa aggcatcgct tcttcctttc aaagcgctct gcatatttta 2742961 ggggagcacc atattgacct cattttgctt gatatttata tgccgggaaa aaacgggctg 2743021 gaactgctga cggaattgag agcccaaaat gaagcggttg acgtgattgt catctcagcg 2743081 gccagcgagc ttgacgtgat caagaaaaca cttcggtacg gagctgttga ttatttaatc 2743141 aaaccgtttg aatttgaacg attccaaacg gctctgtctg attacagacg aaaacaaaag 2743201 gtgtattcaa cccatcgcaa catgagccaa aaagaactgg acgccgagct ttttcaaaag 2743261 aaagaagcaa cagaaaaagt gcagcttcct aaaggcctga caaaaagcac gctgaagctg 2743321 atctggtcca gtatccagtc atttgaaaat gaatctttta cgacagaaga cttggcaaag 2743381 cacacagaaa tctctcaagt atccatacga aaatacttaa agtttcttga agatatacag 2743441 gttctgaatg tagaaatggc gtacggaacg atcggaagac ctgtgtttca gtacaacgtc 2743501 aacaacagta acattaacgg aataaagcaa tatctataag aaaacgcact gcttgctttg 2743561 agcagtgcgt ttttctgtca tatctcttgc caagatgctt gattctattg ttgataagtt 2743621 atacaagaat aacaaagggc tttcacattt ttaagcaaat aattctaaaa atagataatt 2743681 tttaaaaaat tatgcgaaat tctatttatt tcttattagt taaatgataa attatgattg 2743741 gttagttgat cccgaaaaac taagtcataa gtcttacttc agaaaacgat gtcacggttt 2743801 tccgcccgga acgccttccg catccttctc ttccccgcct ttcgaaggaa atactcacac 2743861 cacgcttatt cagggaagaa tagaactgtc tcagcgcatt ccatttgtta ttatcagaaa 2743921 attttatcga ttctaagaaa ttgttcagga cagcccatca catgactggc cggatcagct 2743981 ttgaaccaaa tttttctggg gggttatatc ttgaataaac gaaaaatcgg attggcgatg 2744041 tcacttgtga tcgcagcagg caccatatta ggagcatgcg gaaacagcga aaaaagcagc 2744101 ggctcaggcg aaggcaaaaa caaattcagt gtggcgatgg ttactgacgt aggcggagtg 2744161 gatgacaaat ccttcaacca atcagcctgg gaaggcatcc aagcctttgg gaaagagaat 2744221 gggctgaaaa aaggcaaaaa cggttacgac tatcttcaat ccaaatctga tgcagactat 2744281 acaacgaact taaataaatt ggcgcgtgag aattttgact taatttacgg cgtcggctac 2744341 ttaatggagg attcaatcag cgaaattgct gaccagcgta aaaatacaaa ctttgcgatt 2744401 atagatgctg ttgtcgataa agacaacgtc gcaagtatta cgtttaaaga gcaggaaggc 2744461 tcatttctcg tcggagtggc cgcagcccta tcaagcaaat caggaaaaat cggctttgta 2744521 ggcggcatgg aatcagagtt gatcaaaaaa ttcgaggtcg gcttccgtgc cggcgtgcaa 2744581 gcagttaacc ctaaagccgt tgtagaagtg aaatacgcag ggggtttcga taaagccgat 2744641 gtcggtaaag caaccgccga aagcatgtat aaatcaggcg tagatgttat ttatcactct 2744701 gcgggcgcca ctggcacagg cgtctttact gaagcgaaaa acctgaaaaa agaagatcca 2744761 aaacgcgatg tctgggtcat cggtgtcgat aaagaccaat acgcagaagg ccaggtagaa 2744821 ggaacagatg ataacgtcac cctcacttcc atggtgaaaa aagtagatac agtcgttgaa 2744881 gatgtaacga aaaaagcgag tgacggaaag ttcccgggcg gcgaaacact tacctacggg 2744941 cttgatcaag acggagtcgg catttctcca tctaaacaaa atctatcgga tgatgtgatc 2745001 aaagcggtcg ataaatggaa gaaaaaaatc atcgacggat tggaaatccc ggcaactgag 2745061 aaagagctga aaaccttcaa agctgaataa gaatcgcagg gataaggagg tcgagccctt 2745121 atcccttgtt tttcttttat tttgaaataa aggagcggtc aatcaatgga atatgtcatt 2745181 gaaatgctca atatccgcaa ggcgtttcca ggtatcgtcg ccaatgacaa tatcaatctt 2745241 caagtcaaaa aaggcgaaat acacgcgttg ctcggtgaaa acggagcggg gaaatcaaca 2745301 ttgatgaatg tccttttcgg gctgtatcag ccggagcggg gtgaaattcg ggtgcgcggc 2745361 gagaaggtgc acatcaacag cccgaacaaa gcgaatgacc ttggaattgg aatggtgcac 2745421 cagcacttta tgcttgttga cacctttaca gttgctgaaa atattattct cgggaaggag 2745481 ccaaagaagt ttggcagaat tgaccggaag cgtgctggcc aagaggtgca ggacatttcc 2745541 gatcgatacg gcctgcagat ccatcctgaa gcaaaagcag ctgacatatc agtcggtatg 2745601 cagcagcgcg cagaaatatt aaaaaccctc taccgcggtg ccgacattct gatttttgat 2745661 gaaccgacgg ctgttttgac gcctcatgaa attaaggaac tgatgcaaat tatgaagaac 2745721 ctggtcaaag aagggaagtc catcatctta atcacccata agctgaaaga gattatggag 2745781 atttgtgacc gcgttacggt tatccgtaaa ggaaaaggca tcaaaaccct tgatgtccgt 2745841 gatacaaacc aagacgaact cgccagtcta atggtcggcc gtgaggtatc gttcaaaact 2745901 gaaaagagag ctgctcagcc gggagcggaa gtgcttgcga ttgacggcat aactgtaaag 2745961 gatacccgcg gaatagagac agtcagagat ttgtctcttt ctgtcaaagc gggagaaata 2746021 gtcggcatag caggcgtcga cggaaacggg caatctgagc tgatcgaagc ggtgacagga 2746081 ctccgcaaaa cagattcagg aacaatcacc ttaaacggaa aacagatcca aaacctgacg 2746141 ccaagaaaaa tcactgaatc cgggatcggg catattcctc aggatcgcca taaacacggt 2746201 ctcgtccttg attttccaat cggagagaat atcctgctgc aaagctatta caaaaagccg 2746261 tattcagcat tgggcgtttt acataaaggc gaaatgtaca aaaaagcacg cagcctgatc 2746321 actgagtacg atgtcagaac gccggatgaa tatacacacg ctcgggcatt gtcaggcgga 2746381 aaccagcaaa aagcgattat cgggcgggaa atagaccgaa atcctgattt attaattgcc 2746441 gcccagccga ctcgcggcct tgatgtcgga gcgattgaat ttgtccataa aaagctcatt 2746501 gagcagcgtg atgccgggaa agccgttctt ctcctctcgt ttgagcttga agaaattatg 2746561 aatctcagtg acagaatcgc cgttattttt gaaggacgca ttatcgccag cgttaatccg 2746621 caggaaacca ctgaacagga gcttggtctc ttgatggcag gaagcacgca aaaggaagcg 2746681 gggaaagcaa atggttaaac gactctctca tttactcgtg ccgctcatcg caatcatact 2746741 tggtcttgcg gccggcgcgt tgattatgct tgtgagcggc tacagtgtgg ctagcggata 2746801 ttcggctttg tggaatggga tattcggaga aatctattat gtcggagaaa caatccggca 2746861 aattacgcct tatattttat ccggattggc tgtcgccttt gcattccgaa ccggactctt 2746921 taatatcggc gtcgagggac agctgctcgt cggctggaca gcagcggttt gggtcggtac 2746981 ggcgtttgac ggaccggcat atattcactt gccgctcgca ttgattacag cggcagctgc 2747041 aggaggatta tgggggttta ttcccggcat tttgaaagcg cgattttacg ttcatgaagt 2747101 cattgtcacc attatgatga attatatcgc gctgcacatg accaattaca tcatttcaaa 2747161 cgtcttgaca gatcatcagg acaagacggg gaaaattcac gaatccgcct ccctccgctc 2747221 tccttttctt gaacagatca ccgattactc acggctgcat ttgggaatca tcgttgccct 2747281 tctcgcagca gttatcatgt ggtttatcat caacaaatct acaaaaggat ttgagctccg 2747341 ggcggtcggg tttaaccagc acgcttccca gtatgccggc atgagcgtgc ggaagaatat 2747401 catgacctcc atgcttatct ccggcgcttt tgcaggtctt gccggagcca tggagggcct 2747461 agggacattc gaatacgcag cagtgaaagg cgcatttacc ggcgtaggct ttgacggtat 2747521 cgctgtcgct cttctcgggg gaaacacagc cgtaggcgtt gtactggcag catgcctgct 2747581 tggcgggctg aaaatcggcg cattaaatat gccgattgaa tcaggcgttc catcagaggt 2747641 cgttgatatt gtgattgcca ttattattct atttgtggct tcaagctatg cgattcgttt 2747701 cgtcatgggc aaattgaaga aaaagggggc gaactaagtg gacattgtgc agattttatc 2747761 tatcattgtc cctgccacac tcgtctatgc ggccccgctt attttaactg ctctcggcgg 2747821 cgtgttttcc gagagatcag gtgtggtgaa tatcggccta gaaggcctca tgattatcgg 2747881 ggcgttcacc agcgtgttat ttaatttatt ttttggtcag gaattaggtg ccgccgcacc 2747941 ttggctttcg ctccttgccg ccatggcagc aggcgccctg ttttcactga ttcacgcggc 2748001 agcggcgatt tcgtttcgcg ccgaccagac agtcagcggt gtcgccatta acatgctggc 2748061 gcttggggca actttattta tcgtcaaact gatctacggc aaagcgcaga cagacaaaat 2748121 tccagagcct ttttataaga cgaaaatccc cggtttgggc gatattcccg tcttgggaaa 2748181 gatcttcttt tcggatgtct attatacgtc tattcttgca atagcacttg cctttatttc 2748241 ctggtttatc ttgttcaaaa cgccgttcgg ccttcgtatc cgttctgtcg gcgagcatcc 2748301 gatggcggcc gatacgatgg gaatcaacgt atataaaatg cgctacatcg gcgtgatgat 2748361 cagcggattg ttcggcggtc tcggcggcgg cgtatatgcc tccacaattg cgcttgattt 2748421 cacgcactct accatctccg ggcaaggttt tatcgccctg gcagcgcttg tattcggaaa 2748481 atggcatccg atcggagcac tgggggccgc cctgtttttc ggattcgccc aaagcttaag 2748541 catcattgga tcgctgctcc ctctttttaa agacatacca aatgtgtata tgctgatggc 2748601 tccttatatc ttaacgattc tcgctttaac cggctttatc gggcgggcag atgcgccaaa 2748661 agccaatggc gtgccttata ttaaaggaaa aagataaaca ttctcccctg ggaagacgat 2748721 tctcagggat ttttttctaa tccaaaagac ccccttaatt taattgttta ttagtttttt 2748781 aacttaaaaa aatatgaagt gttaacgctt tcttgtagac tgtaacaaac aatacatggg 2748841 ggtgtatgac atgggagcaa ttccaaaaac ggggacaatt tcacctgagc aaaaagactc 2748901 acaggagaaa aacctgtttc aaaaaatttg gtcttgggaa atcggtgtga ttcctttgcc 2748961 attatacaca gtattagctg ttattattat tcttgcagca tattacaatg agctgccggc 2749021 aaatatgctt ggcgggtttg ccatcattat gattcttggt gtgtttctcg gagacatagg 2749081 ccaacgcata ccgatattga aggatattgg cggccctgct attttatctt tgtttgttcc 2749141 ttcattttta gtcttttaca atgtactgaa ttcaacatct ttagacgctg taaccaactt 2749201 gatgaaaacg tctaacttcc tttatttcta tatcgcttgc cttgttgtgg gaagtatcct 2749261 cggtatgaac agaattgttt taatacaggg gtttatcaga atgttcgttc cactggttgc 2749321 aggaacgatc gcggccgttg cagccggcat ccttgtcgga tttatttttg gctatagtgc 2749381 ctatgattcc tttttctttg ttgttgtccc gattattgcc gggggaatag gtgaagggat 2749441 tttgccgctt tcaatcgcct attcacaaat actgggctca tccgccgatg tatttgtgtc 2749501 tcagctggtg ccagccgcaa ttataggaaa cgtttttgct atcatatgtg cagccttaat 2749561 gaaaaagctt ggcgacaagc gtccagatct aaatgggaac ggacgtctcg taaaatctaa 2749621 aaaagcaaat gagattttca atcaaaaaga agccgaagca aaaattgatt ttaaactaat 2749681 gggagcagga gttctgctcg cgtgtacatt ctttattttt ggcgggttat tggagaaatt 2749741 catcttcatc ccgggcgcga tcttaatgat tatttcagct gcggctgtca agtatgcaaa 2749801 tattcttccg aaaaaaatgg aagaaggcgc ttaccagctt tataagttta tttcttcaag 2749861 ctttacatgg ccgctgatgg tcggtctcgg catcctcttt attccgttgg atgacgtagc 2749921 gtctgtgatt tctataccgt ttgtcatcat ctgtatttca gttgttatcg cgatgattgg 2749981 ttctggatat ttcgtaggca agctgatgaa catgtatccg gttgaatccg caatcgttac 2750041 ctgctgccac agcggtctcg gcggaacggg tgatgttgcc attttatcgg catcaggaag 2750101 aatgggcctt atgccgtttg cccaaatttc aacccgtctc ggcggtgcag gcacagttat 2750161 ttgcgcgaca gtgctgcttc gttttttcac ttcataaaca gaaagagttc cgttttatgc 2750221 ggaactcttt ttttatttat tcacaatccg aatatactct cggggaccaa acggcagatc 2750281 ctttgattcc gtctcactca ttctggctga caggtggtgc tccagtaaat acagctccca 2750341 ctcatcacaa gccgccacac cgctgcgccc gtcatattga ttcaacatga atgcccctgc 2750401 aaatactgag cagaataaac ctgagcacat cacgactttt gttttcacat gaccagctcc 2750461 tttccttcag cttgatcagg attgatttta aatatacaaa taacctcttt tttgttagac 2750521 ttattttgag gtcaaaagaa ctcataaaaa tccattacag cagttcgaag cgtggcagct 2750581 tgcagaaaag tgcgatataa tttggactag gtcgtttgac cgtatatttt atacatagcg 2750641 catttttcaa ttgagaacga gaaaaggagg tcttatcttt gcagctctta catcttgcta 2750701 ttttatcgcc ttttttattt gcttttatca ttcccttctt ggcaaaatac gcaaaaagag 2750761 tgcatacggg ctggtttgtg ttgatcctgc ccgtcttgct gtttatatac tttctcccaa 2750821 tgatcaggat gacgcaatct ggagaaacac ttcgatcggt attagagtgg attccgtcac 2750881 tcggcattaa ctttaccgtt tatatagacg gcctcgggtt attattcgct ttactgatca 2750941 caggcattgg ctctttggtc actctttaca gcatttttta tttatcgaaa gaaaaagaac 2751001 agcttgggcc cttttatgtc tacttattga tgttcatggg cgccatgctc ggcgtcgttc 2751061 tagtagacaa tgtcatggtt ctctacatgt tctgggagct tacaagcctt tcatcctttt 2751121 tgctgatcgg ctattggtat aagcgggaaa agtcgcgcta tggcgcagcc aaatcacttt 2751181 tgattacggt cagcggcggg ctgtgcatgc tcggcggatt tattctcctt tatttgataa 2751241 cggattcctt cagtattcga gagatggttc accaggttca attaattgcc ggccacgaat 2751301 tgtttatccc ggctatgatt ctcattttat taggggcttt tacgaaatcg gcgcaatttc 2751361 ctttttacat ctggctccct gacgcgatgg aagctccgac gcctgtcagc gcttatctcc 2751421 attcagctac tatggtaaaa gccggcattt atgtgattgc gagattcagt cctattttcg 2751481 ccttttcagc tcagtggttt tggatcgtgt ccctcgtcgg cctctttacg atggtttggg 2751541 gttcattcca tgccgtgaaa caaactgatt taaaatcgat tttggcgttt tcaaccgtca 2751601 gccagctcgg catgatcatc tccatgctcg gagtcagtgc tgcggccctt cattacggac 2751661 atacagaata ttatacagtt gccgctatgg ctgccatttt ccatttgatc aaccacgcaa 2751721 cctttaaagg aagcttgttt atggcagtcg ggattatcga tcacgaaaca ggcacacggg 2751781 atatccggaa gctaggcggc ctgatggcga ttatgccgat tacttttacc atttccttaa 2751841 tcgggacatt ttcaatggcc ggcctaccgc cgtttaacgg atttttgagt aaagaaatgt 2751901 ttttcacaag catgcttcgc gtgacacatt ttgacctgtt caacgtgcag acatggggcg 2751961 ttctgttccc tcttttcgcc tggatcggaa gtgtatttac gtttatctac agcatgaaat 2752021 tgctgtttaa aacattcaga ggaaattacc agcctgaaca gcttgaaaaa caggctcacg 2752081 aagcgcctgt cggtatgctc gttccaccgg tcattcttgt cgctttggct gtcagtctct 2752141 tctttttccc gaatatattg tcgtacagcc tgatagagcc tgcgatgaac tcaatctatc 2752201 cgacactgct tgacggccat gagaaattcc acgttcacat ttcacagtgg catggggtta 2752261 caacggaatt gctcatgact gcgggtattg ttgtgatcgg aacaattggt tatttgtcgc 2752321 tgaataagtg gaaaggaatc tataaactgt ttccttcgaa actcacactc aaccggttat 2752381 acgataagct tttgactatg atggagaaag gctcttaccg ggtcacaaaa caatatatga 2752441 ccgggttttt aagagattat ttgctgtata tcttcgctgg tttcatcatt ctgataggcg 2752501 gagcttttgc cattaaaggc ggattttcat ttaaaacgga aggcatggct aaaatcggtg 2752561 tatacgaaat cattttgacg cttgtcatga tcagcgccac agtggcgact gtttttgcta 2752621 ggtcaagact gacggcgatc attgcactcg gtgttgtcgg ttatacgctt gcattgtttt 2752681 ttgtcatttt cagagcgccg gacttggcat tgactcagct cgtcattgaa acgatttctg 2752741 tggcactgtt tctgctttgc ttctaccatt tgccgaaact gaggctgaaa acaaaaacga 2752801 gaacgttccg gatgacgaat tttatcattt ctttaggcgt cggtgttatc gttacactgc 2752861 tcggcatcgc atcctcaagc cagcggacaa aagacagcat tgcgtccttc tttgtcaaac 2752921 acagccacga tctcggcgga ggggataatg tcgtcaatgt cattctcgtt gatttcaggg 2752981 gatttgatac aatgtttgaa attacggtat taacgatagc cgctctcggc atttacagca 2753041 tgattaaaac aaaagtaaaa gaggagggga aaagcggtga atgaacaaaa aacaaatgac 2753101 ttgattcttc aaaccgcgac aaagcttgta tcctttatca ttttgctttt ctctttctat 2753161 ttatttttat cagggcataa cgcgcccgga ggaggctttg tcggcggact gatcacgtcc 2753221 tcttccatcg ttctcttgct cttggcatat gatttaaaaa ccgtgcgttc ccttttgcct 2753281 gtcaatttca tttatgtcgc gggagccggc cttctgctcg ctgtattaac aggcgttggc 2753341 tcctttgtct tcggggctcc ttttttaacc cacacattcg gatactttca gctgccgatc 2753401 cttgggaaaa cggagctcgc cacagcgacg atatttgatt taggcgttta tcttgttgtc 2753461 gtaggcataa cgatgaccat tattcaaacg attggagagg aagaataatg gaaatcttaa 2753521 tggctgtatt agccggtatt atttttatgg ctgctacgta tttgctgctg tctaaaagcc 2753581 tgcttcgcgt cattatcgga acagcactgt taagccatgg cgttcattta atgcttttga 2753641 ctatgggagg attaaagaaa ggcgccgctc cgattttgag cgagcatgcc aaatcatttg 2753701 tcgatccgct tccgcaagcc ctgattttga ccgcaattgt catttctttt ggcgttacgt 2753761 cattcatcct cgtcatggcc tttcgcgctt atcaggaatt gaaatcggac gatatggatc 2753821 aaatgagggg aaatgatcaa catgaataat tttgttattt tgccaatcct gatcccgctt 2753881 ttgtcggcta ttcttctgat tttcatgacg aagaatctta tgctcatgag aatcttcagc 2753941 acggcggcat cggccatcgg gattgtgatt agcggcatac ttgtacagac tgtcttcaca 2754001 aaaggcatcc agacactcag cctaggcgga tggaaagcgc cgtacggcat tgtgcttgcc 2754061 gcagaccaat tcgccagcct tctcgttctc acaacagcga tcatcggttt attggttggg 2754121 ctttattcct tccgttctgt cggtgaaaaa cgggagcgct ccttttacta ctccggcgtt 2754181 cagttcttgc ttgccggcgt cagcggagcg tttttaacag gcgatttatt taatatgtac 2754241 gtattttttg agcttctgct tattgcttcc tatatgctga ttgtattagg cggcacaaaa 2754301 attcagctgc gggaatccct taaatatatt gtgtttaata ttgtatcgtc tgccctgttt 2754361 gtcatagggg tcggcttttt atacgctgta accggtacgt taaacatggc ggatcttagc 2754421 gtgaaaatca gcgaatcagg acaaaccggg ctgatcactg tgattggtgt cctgctgctt 2754481 ttggtatttg gcatgaaggg cggaatcttc cccctctact tttggcttcc aggctcttat 2754541 tacgcgccac cggcggcaat ctccgcgttg ttcggcgctt tgctgacaaa agtcgggtta 2754601 tatgcgatta cgagggtttt cacattgatt tttattcacg atacagcctt tacccatcag 2754661 ttgatgattt ggctggcggc gctgactgtg atttttggtg tgatcggttc actcgcttat 2754721 tcgaatgtca tgaaaattgt gatctataac attattaccg ctgtcggcgt gattttgttc 2754781 ggtgtggcag tacacacccc cgcatccatt cagggcgcga tctactatct gattcacgat 2754841 atgctgatta agggcgcttt gttcatgctg gcaggtacgc tgatcgcatt gactggaacc 2754901 gcgagcctgc ataaaatggg cgggctgatc aaacgctatc ctgttcttgg atggatgttt 2754961 ttcatttccg ctatttctct tgcaggcatt ccgccactga gcggatttgt cggcaaattt 2755021 aaaattgcag agggcggctt cgcagaaggt gaatttacga tatccatgct gattctgctt 2755081 tcgagtctgc ttgtactgta ctctgtgctg aggatcttta tacatgcgtt ttggggcgaa 2755141 gaaaaagaaa cgccaaaacc aaatcatcga acagctaaag gacttcttta tccggcagct 2755201 atttttctct tgctgtccct tctcttcgga ttgggtacag aatgggtgtc gccttacgtt 2755261 gatcaagcgg ccgagacgct gctgaatccg gaaaaatata tcgaagctgt tctgaaggag 2755321 tagatcgcat ggcatttcaa attttattaa atgtgtttct cgctttttgc tggatgttct 2755381 taagcaacag tccaagcgcc gcaggattca ttacaggcta tattctggga atgctctctc 2755441 tctttttctt ccggcgcttt ttcactcgcc agttttatct atggaaattg atttctatta 2755501 tcaagctctg tttcattttt ataaaggaac tgtaccttgc caatgtcagt gtgatgaaat 2755561 cagtcttatc tccaaaactg aatatcagac cgggtatttt tgcttttaaa actgaactga 2755621 cgaaggactg ggaaatcacc atgctttctc tgctcattac attaacgccg ggaaccttgg 2755681 tgatggatat ttcagatgac agaacaatac tttatattca tgcaatggat atcgaggatg 2755741 cggaaaaagc gatttttgac attcgggagt catttgaaaa agccatacag gaggtgagcc 2755801 ggtgatgttt acgctgatcc tgcaaatcgc gctcggcatt atggcagtgt ctaccttttt 2755861 gtatgtcatt cgtgtcatta aaggtccgac tgtgcctgac cgggtcgtgg ctctggatgc 2755921 aatcggcatc aatctgatcg caatcacggc gcttgtctcc attttgctga aaacaagtgc 2755981 gtttttggat attattttgt tgctggggat tttatcgttt atcggaacga tcgcattttc 2756041 caagttcctg gagaaaggag agattatcga aaatgatcga aaccgctaag gtcgttgtgg 2756101 ctgtattcat tttgctgggt gctcttatat gcctcattgc ttcatttggc gtacttcgcc 2756161 ttcccgatgt gtttacacgc gctcatgctg cttctaaagg ctcaacatta ggtgtcaata 2756221 tgattctgct cggtgtcttc ttctatttgt ggtttgtgac gggggagctc tccgctaaaa 2756281 tcctgcttgg gattctcttt atctttatta cgtcgcctat cggcgggcac ttgatctgcc 2756341 gtgctgcgta taactccggc gtcaagcttg atgagagaag tgtgcaagat gactataacg 2756401 gaatcagaaa ctttgtgatt aaacgaaaag aggattctta tttataaaaa taagcagccg 2756461 gacaggcaga gttccggctg tttttttatt tcttgatgac agccagcgtg catctggata 2756521 tacagatcag cctctcttgc tcgtcatata tgtgaatatg atagacaatc gtcgttctgc 2756581 ctatatgaac gggctcggct atcgccttta ccgttccttc ctttacagat tttaaatggt 2756641 tggcgttaat ctccaaacca acacaagctt gcgttgtatg atcaatcagg ttctgtgcac 2756701 ctgcgctcgc cgcggtttcc gccagggcca ctgaagcgcc tccatgcaaa tatccgaacg 2756761 gctgtaccgt ccgatgatcc accggcatga ccgcaacgca tcgttccgct gtgttttcaa 2756821 caatctcaat accaagcgct tcaagcaatg tgtgcttcat atccatctct acacccccca 2756881 acatttaaag tacaccgtct gatttcgcaa tcaaaaccgc ttccgtccgt gaaccgacat 2756941 tcagcttatt gaaaatcgat gtcaagctgt attcaatgga ccgcttgctt aaatgaaggg 2757001 catctgcgat ttcttggttt gtaaatccct tttcaacttc ttgaagaatc aggcattctc 2757061 taggtgtgag cacatcttgt tctttttgag aggaaggagc cggctttgtt ttttgctgag 2757121 tcatcagctg tttaaagtaa gcaaaatcga ctaaaatttc tccgttgagt acgtggtata 2757181 tgtattgggt gatcttttct ttagattccg ttttgctgat ggcaccgtgc agacccgcac 2757241 gaatcgcttc ctcgaaataa tcctcgacct cataaccggt atacacgata attttacaat 2757301 gaggattctc ttgtaaaatc tgtttagaaa gctccatccc attgacctcg ccgcctagat 2757361 tcagatccat taaaatgaga tcatatgacg agaaatcatg ctgcttgata aactgttcgc 2757421 tcggttcagg actgagacaa tcaacagaca aattcgaatc cgtttccaaa attgtcttgg 2757481 tgccttccat gacagccgga tggtcatcaa tcactagtat ctttttcatg ttttcctccc 2757541 ttttactcac tcttttccat tttataaaaa agacttggcc tgtgccaagt cgtttccgtt 2757601 ataaatccat tacaattcga tttcaatatc agccttaaag ccctttcctt cacttgtttc 2757661 aatccgaagg cgcccatcta aagccctgac tctctcctta atgccagaaa gccccatgct 2757721 catggaatgc tcagtatttt tttcttgatc aaacccaacg ccatcgtcct cataatgaag 2757781 aacgattttg ttttgaatac tgatgagcat aatcagcaca tccgtcgcct gagagtgctt 2757841 gaccgcatta gacagaaact cttgaatgat ccggtacaaa ttcagctgcg aatccagatc 2757901 aagggaagcc gtaaatctcc cggtatttaa acggatatga aacggaaccc gctcctgctg 2757961 ctgcgccacc agcttcgaca gcgccttcac caatccaaga tcatacagaa gctgcggccg 2758021 cagctcatga cacgtctccc tcgtcatcga aatcacatca gacatctgct cattcatctg 2758081 tacaagcttg tcctgcacct cttcacggca cggattatca tccttcttga aatcacccaa 2758141 aaacagctca cactggcgtt ttaaggaaat caaatcctga agaaccgaat cgtggagatc 2758201 gcgggcgagt cctgaacgct gtttttcttc gattgcaaac attagctttt tcagccagat 2758261 ggggttggtt ccctcttgtt ttaagtcctt caaatgttcc atgagctcct caatatgcag 2758321 gacattttcc atggacacac ttgtataaaa agacagtgtt ttcagccacg atatttcatc 2758381 acgtgttagc cggggagtgt taatattaga taaacaaagc agaacataag aactaccgcc 2758441 tcgttcacca actttcataa gaaagccttg attgacttct ataattttcc caatttctga 2758501 agttacgttt tcaaattcct cttgataaaa attccagtcc ggtccaactt catgcttatc 2758561 taaaaatatc actttgtgat caggagtaac ctcaaaggta taagctttgc ttacaagcaa 2758621 aacatccagt atagtatttt tcagttcttt aaaaacttgt tgaagagaag ttacacccct 2758681 cattagctga gtatatttaa aaatactgtc ctgatagttg aatttttcgg agaaacgttt 2758741 taaccgaaat ttaaaatcca tgacctcttt aaaataaaag acagcgaaca tgacaacgaa 2758801 aaaaaataca gtttgacgca cagggttcat ctggatgtcc attacatcaa acagaactaa 2758861 tgcaccaact attagaagag ttggtatcat ggcaagtaga gcatagtatc tcattcttcc 2758921 taagataaac tctatatcaa acatcttatt ggctacaaat tggtatacta acccgaacgg 2758981 aattagtact agtaatgacg ccgaagctaa tgccgggaaa atataattac ctgtaaatat 2759041 tattggaaga acaaaaaata tcaaaaaagg cgcaaatgaa agagtgtttg ttaaaattag 2759101 taatttaaga ataaacgaat gctcagcata tttatattta ttaagatgta agtatatcgc 2759161 tgaaaaagaa aatagagtca aagttgcaaa agaaaccaaa ttaagagttg ctaaaaaatc 2759221 aatatctact tgtaaatagt cttgaaaaaa ctcaatacca agattaaata ttggtatgat 2759281 ataaagaaaa gaaattctat tcaaaaaagt tttacctatt tctccaaggt atctttgtat 2759341 aaattgaaga taaagaatag gagaagatat aaaagtaaac aagttaatat accgattgat 2759401 tatatgtcct ctaaatggtc cgcctgcact tatatatgct atcgaaatgt ctaataacaa 2759461 tagaataaga atataggcag caaatgatct ccttttttta tttactttaa gtatataaaa 2759521 aatacatatt atgcttaaaa aataaaaaaa caaaggaagt acgaacagaa aaaaactata 2759581 aggtctattt agagtaacta aatcaaaatc tttgagatga atcttttttc cacttctcaa 2759641 aatatccaga ctgttaatat gactcaaata tccccatttc aaatgtttgt ctgaaggttt 2759701 ttctttatta atttttaata tgatgtctcc ctgtctcaga ccaacaaatt gtccatatga 2759761 agattccgat atttcttcta tcataaattg acttttatca tttttatgaa tcttagtccc 2759821 aataataatt ccattcatac tgatataagt tgtatagctt atataaagga tactcaaaac 2759881 aattacagct attgtgaatt tttttattaa gttcttcaat attaatccac ctattaatca 2759941 ccccattgac gggttattgg atcagccaga taataatcat tataagcttt aattattgtt 2760001 tcagtttctt gcacatcaaa acctataagg caggcttctt tatttttcaa tttttttaaa 2760061 gcctcaggat aatttaaaaa gtagttaatt aggtcttgca tcttgtatcc ccctttgtat 2760121 aacttaataa gcattccttt attagctctt tttttcttta tctaaattta attgttctat 2760181 agcagaaata catttctgtt tatatatttc caataatacc gaaatgtatt gagtaactcc 2760241 cgctttaatt aatttttctt ggaatttctc tttatcaagt aacgatttat aatataagtc 2760301 tttatgtgaa attaagtata ataaatcttc cgaagcatca ttaaaaaggc gcttaagata 2760361 taagtaaatc agtgtatgtt tgtttttttc aatatcactg cgatttccgg ataaaagaac 2760421 ataataatct ccagaaattt gagctataat ccctttatag taggaatatc tttcaactgt 2760481 ttcattatat tctcctgtag ccaataaaac acctgctaca tttgctagtg caatcagact 2760541 tccacatttt aatctaatta cttctaaact ttcatcttct gttttagatt tattagtgat 2760601 atcgtcatgt tgaccttgca tggcctcgtt tacgtatttt aaaacatatt taaaaattag 2760661 aggattgtta tttaatgaat aaatactcgt taatcctact gtatacaagg aaagtgctgc 2760721 atttaacgac tccgagcgat taattttcat ccataatgca tggtgattat cttcatcttc 2760781 aagatcatcc ataatatctg atgaaagaat aagaatttct attcccgcgc caagccttgt 2760841 tgcaacatct aaattctccc ctccaaaaac aacataatgt aagattgtgg attcagcaaa 2760901 ggagaatgtt tctttagaat caataaatga gtaaagaagt tgtgacaaat cctcgttaaa 2760961 tatgttttgc tccacaatct ccttcatttt ctccttgatc cggacagaat ctaaacatat 2761021 ctgctcaata acgacttccc ccctcccatt ccattttact aaatgggaca tttaaaggac 2761081 agcaggtttt tcgtttttta acaatcatat aatactttat ccatttattg tatcggtaga 2761141 acgaaaaaaa agacttgttt ccaagtcttt ttcacgaaat tttcattgca taattgtatt 2761201 tatcgagttg atcaatgctt ttgttaatgt ttcgtaatga atctgtcgtt tctttaatat 2761261 caagttcgag tcggaataac aattgtttta cttcttcaag tttcttttcc atcgtttcca 2761321 cactcctttt tttgaaagat caatgaattg tgtatggtga acgagtccta ggtatttgat 2761381 ctgttactaa tagtgtgtct gctttcggct catttttcac cgaaaagtat gcaaaaaagt 2761441 cctgcgtgac accgcaaatc tcaataggtc cttatactca aaggaatcac aacaagaacg 2761501 ggactatctt tctatgcgaa agagcgttta tatgtgctga aattgagaaa gattcttaat 2761561 ctccttgatt ttaacgggtt tcgcattttc actaagcaag actatagtcc ttcataccgt 2761621 attttcaaaa ttgaatatgc gattcttggc gtttcctgac cgacaaacac cgaaaaagac 2761681 cgcaacgcta aagttgtggc cttttcgctt tgtcatattc ggcaattagg gatctataca 2761741 tatagaaaca tccttttttg cgaggtgctc ccatgagata tcgttatccc tggttttacg 2761801 tgtatccgta tgaggtacgc cgtccgcccg ctcctgccaa caatattgat acctttatcc 2761861 gttcagcgaa gcaggccgca gggatatttg cggatgccca gctcgttctc agccgcattg 2761921 cgggctcgcg ggagctttcg cgccgcattc tgaccgcagc cgaacagtct gataaacaaa 2761981 ctataaggcg cctgatcaaa caaatgggcg tccggcatga agtggatacg gtctttaatc 2762041 ccgacggcat ctatatcagc cttatcggaa cgcaaagccg aatgattctt gctttgcggt 2762101 ggtcagagga ccgcaatcat tttgcgtcca taagattatg acaccattcc agagcctcta 2762161 aataacattc atacgcttct tctttgtcca gttgattgcc taattctgag caagtgtccc 2762221 agttgttgct ttcaattaat ttcacaagct caagcatttg gtagtagtcg ttttgatggc 2762281 ctaataatgc ttgcccgact tcatctttta aaggcaattc ttgaacaatt tcctctattt 2762341 ctctatgcag gagggtgtct atgagagaaa acattccgat cagcatataa gaagcaggct 2762401 gcggccggga tgtctttctc gccagcagtt cgcaaagctt tgctcttatc agagaaatct 2762461 taatgatttc gtgcttgctg gaatgccctt tcctgcttaa atccttaaag gaaagaatat 2762521 atatccaccg tttgatttca ttaaatccca gcagcataat ggcctgttga atgctttcaa 2762581 ttttctggct caaacggctg tgggatgagt ttaaaaattt taaaatttga taggacagtg 2762641 ataaatcccg ctctatgtac tctgtcacac gctttatgtt aggctgctct ttactcagtt 2762701 cgttaagcag ttcatagtaa gaatagaaat gagtcgatag gtcatgcccg ctgatgatgc 2762761 gcggctcgct gaaaaagtag ccttggaata attgaaagcc gtcttggacc gcctgtttat 2762821 attcttttcg ggtctctact ttttccgcta aaaaaatcag gccgcggcag ccgtaggttt 2762881 gcaaaattgt tctgcgttcc attcgtgttg ttttgagaaa atcaattttc aatatatcaa 2762941 tatagctcat gagtttttcc agtaagtcct catcttgcgg atttattgca taaaaatcat 2763001 caagcgccag catatacccc atttttttca attctttgca tctagaaatg agggccggcg 2763061 tgatcggtat atcttcaagg atttcaatga caagctgttt cggattgaag gaggtgggaa 2763121 gattcgaaaa catcaggctt tccgtaaaat taacaaaaca gcgtttccct tccgtcagct 2763181 tctcaattcc gatgtttaaa aagctgttga tcaccaaatc tgttgttgcc tgatcgccgt 2763241 ctttagcgct atacacgttc tcttcgcttt ctctatacag cagttcataa gcaacaacct 2763301 gttcttttct attaaaaata ggctgtcttg caacaaacac cctcattgat ttatccccct 2763361 tacaatacgc gcggctttca cccctaagta tatcaaataa tttgacgaaa attgtctaaa 2763421 catgaaaaat aatatataca taaagaaaac tggcccttcg cgaatgaaag gccagttttt 2763481 ctttattctt cctcaagctc ttcttcaatt ctgcttttca cttcgtggat ccgctgcatt 2763541 ttattgctcc agcagtcctc gcttaaatca accgggtatt cctccggctt gctgattctc 2763601 ttatattcct cccaaagcag gctgaggtta tcctgcacat actgctgtat gtctgaaatc 2763661 tcagggtttt ggtagcaaag aatacccttc tcaaaaatca gttcatgaag atccttcgca 2763721 taaaaattcg tgacaaattt gctgatgaat gtatgaaccg ggtggaacat tctgagccgc 2763781 ttctgatcat tcacctgctc atcataaagc gcaatatagt cgccttcaga atgatggttg 2763841 gactgattaa taatgcggta gactttcttt ctgcccggtg tcgtcacttt ttcaggattg 2763901 gacgaaattt tgatcgtgtc gaccattttc ccgtcttctt caatggcaac gagtttataa 2763961 actgcgccga gagccggctg gtcataggca gtgatcagct tcgtaccgac accccagaca 2764021 tcaatgcgcg ctccctgagc ctttaaattc ataatggtgt gctcatccaa atcgcttgaa 2764081 gcaatcacct tcgcatctgt aaatcctgct tcatcaagca ttttccgggc tttttttgac 2764141 aggtacgcca aatcgccgct gtccagacgg atgccaatga aattaatgcg gtcgccgaat 2764201 tccttggcaa ccctaatcgc gttcggcatg cctgaacgaa gcgtgtcata cgtgtcaact 2764261 aagaagacgc aatccttatg tgtttccgcg tattttttga aagctgtata ttcatcgcgg 2764321 taagcctgca caagcgcatg cgcatgtgtg ccggaaaccg ggatattaaa gcgctttccg 2764381 gctcttacat tgcttgtcgc gctaaagccg ccgattaagg ctgctctcgc tccccacatg 2764441 gccgcatcca tttcgtgcgc ccgtcttgtt ccgaattcaa gcgcaacttc atcaccgatg 2764501 acgcctttaa tccgggcagc ctttgttgcg attaatgttt gatagttcac aatgttgagc 2764561 aaagctgttt caatcagctg cgcttctacc aggggtgcct ccaccctcat aatcggctca 2764621 ttgttaaaaa cgagttctcc ttctttcatg gagtaaagtg aacctgtaaa agataagccg 2764681 cgcaaatatt caataaaatc ttcatgatac ccgagttcat cctgtaaata actcaaatcg 2764741 ctatccgtaa acttgaaatt ttccaagtat tcaatggctt tttccaagcc cgcaaatacg 2764801 gcatagccat tttcaaacgg aagccttctg aaaaacagct caaaaatcgc tttcttttca 2764861 tgaatgccgt ctctccagta cgtttccgcc atattgatct gataaaggtc tgtatgtaat 2764921 gacaggctgt catctttaaa tccgtactct aacactgttt ttccccttcc ttactctgcc 2764981 acttgcgctc cgatgctgtt tgcaaaatgg gaaagagccc atgcgtgccc ctcctgatta 2765041 aagctggcaa cagcttgttt atgcacaaca atccgaaaac ctttgttgta tgcgtcaaca 2765101 gctgtatgca acacacaaat atctgtgcag acaccggcaa gatgcagttc gccaatctgc 2765161 cgctctctga gtttgagctc taaatcagtt cccgcaaaag cagaatatct cgttttttcc 2765221 atgtagtaaa cattaggttc atgttcatgt ttctgatata gaggcaaaag ctttccgtac 2765281 agatcttttc cttccgtgcc ttttatatta tgcggaggaa aaagacgggt ttcagggtga 2765341 tattgatccc cttcatcatg agaatctact gctaatacga cgtaatcacc gtttgtgatg 2765401 aattctttag ttaaattgac gatcgcctct tcaatcattc tgccgggctc cccgcaggtc 2765461 aattttccgt cactcgccac aaaatcattc gtataatcaa tacaaataag tgcttttttc 2765521 atagccggcc tccccgccat cagtatgaga acattatatc ttatctccag ttgtaagtga 2765581 attgccatga acaaaaagac aaacggtccg tttgtctctt acgatttcag tactgaccga 2765641 ttataaatgt cgtcctgaat atatatcaat tcacgattca cagcgatatc agccgcaatg 2765701 acgatgccta agggcgtatg aaactggaga tcagatacaa tcttgaaagg cactccgtac 2765761 cggctcgcca tttggatata agaagagtaa gactgatact gaagctctcc attaatcaaa 2765821 agggtgacgt tatggctgtt tttcagctcg tgctctgcct ctttatacgg tttgcttcta 2765881 agcacctgtc ctttcgtcag tgccaaaacg actctttctc ttaaagagcc taaaaacaaa 2765941 tggcgctcgt caggctttgt ctccaaaggc ccatacattc cttgctgcaa atagagatcc 2766001 attttatctt cactcaaaag cctgtcctcc cgtcttgttt gtcttcatta tcacctgatc 2766061 aggcaggagc taaactttca agcgccgttt acatttctgt tacccaatga atgatttttt 2766121 tggccagctc accagcaggg gtttcctctg tatgccggcg caacgacgct tccagccgtt 2766181 caggcagagt tgctttatct tcttcatagg aaatgatcgt gctccactcc agctgcggta 2766241 ccgctacaag cgtgcgcagt tcttttctgt tttcatgcag atacacgtcc gtgatcattc 2766301 cggtttgcgt attgatattt gcttttctga ttttcataac atgacctctc tattcaaaga 2766361 ctacccatat tatacaataa aaaagcaaca gcctcttgtg aaaaggctgt tacccgttaa 2766421 acgaaactgt ttcatcagtg atatcggcat ctttgaagag agttttactc gtttggttgt 2766481 taatcttcac aaaatcacca agctgaaatg tgcctgaccc cgcccctgaa tgagcgacgc 2766541 ttttgggcga aatcgcaaat acgtctccaa agcttgccgc ggcattatcc gtaactgaca 2766601 tgatataaat cggccccaca attgcaggca tttccccacc tccgcattga tttacagcat 2766661 catatgcaag gagccgataa tggtgcccgc ctattcagct ggctttgcgt tttcctcgag 2766721 tcgtgaccgc tggcgcagct tgatcaagcg gacaatattc aggaagaacg ccttcactac 2766781 cgcataaacc ggcaccgcta aaatcatgcc gagaattccg ccgaagcttc ccgctccgat 2766841 taatagcaaa ataatcgtaa gcggatgggt attcagccgc tttccgatca caagaggaga 2766901 cagcaggttt ccgtccagct gctgaacgat gacgaccaca ataatcgcaa acagcgcttt 2766961 ggccggcgag tccataaaac cgacaatgac agccggcgcg gcaccgagaa aaggcccgac 2767021 atagggaatg atattggtaa tcgccatgac aatcccaaga atcagggcat acggcagtcc 2767081 ggcaattaaa tagccgataa aacacgctgt tccgacaaaa agacagatta acagctgccc 2767141 ctggaaatat gccgcaagcg tatcggataa atctttaaaa atctttaagc cttctgtccg 2767201 ataagaagcc ggtagaattt ttactgccaa atgcggaaag cggtgtccgt ctttcagcat 2767261 gtaaaaaagg ataaatggaa cagtaataat aacaagcgtg atgtttgtca cgacaccaaa 2767321 caccgcagat aaactggacg tgatattttg cggcaggttt tggagaaaac ttgtcaatga 2767381 ctgttcaatt tttgatatcg atacataatc ctggttcatc atccaggtaa accattgaga 2767441 atgggacaaa tcctttgtca gcgcctgaat ctgttttata taatcaggaa ggttgttaaa 2767501 cagccctgtc acctgtgcgg tgatgatagg tccgactgac gctgaaataa aggcaagcaa 2767561 accgataaac agtaaataga tcaatagaat ggataatgtc cgcggaattt ttttctcaag 2767621 caggcggacg accggattaa atatgaaata caaaattccc gcaattagca tcgggaaaaa 2767681 caatgtcgag ataaaaacaa taaacggctg aaatacaaat gaaacttttg ttgctacaaa 2767741 aataatcagc aaaacaaata aaatctgcaa tgtccaaaaa tggacttttg atttcaacaa 2767801 gctttgttcc tcctagtttt tctttgtctg tcagataaaa gaacttatac cccatcattg 2767861 taacaaaaat gaactcatat cagaactctt aatataatga aaggagtgtt ggtgatgaag 2767921 gccgtgacat acgatacaga ttcagaactg gcttatatct atgttcttcc tccgaaaaag 2767981 aacaggaatg tacggactga ggagctcaga gtcaatgatt gtctcctgct ggatatcagc 2768041 caagatggca aaatcgccgg attcgaatgt tttggtgagg cagcacacct ctgtgcccca 2768101 tttgccggga aatcccggct gtatgtaaaa gattcagacg gttatcattt tcgggtctgc 2768161 cagcatgctt cagtccgttc ctgctatacg gtgtaccgtg tcactttctg tttttcagat 2768221 ggtgactatc aggaatttgc cggctttgac cttgatggaa caatgtatca tagtgcgttt 2768281 ttacagcgct taactgaaaa ataggacgtc ctgttgtacg cctatttttc atgcgcaagc 2768341 actgttagac ccgctcactg taatctgggg tgacggaaat catgtgctgg attctgatca 2768401 aacaaacaga atttcgggct ccttcaattg tgatatggtc aggttttaca tcgatcagtc 2768461 tgcctctgac cgtatctcgt actgtctgta taacgaacct tgagccgatg agctttttaa 2768521 tggtctgata gacataagga tcgactaaag agaccagttg cggactacct tggttgacca 2768581 tacttttatc ccctttgtgt gttttatctc agcttatgcc gcgcttatgg ataatgacac 2768641 aggcttacct gataaaacaa aggggtgcgg agattttagg agaatacgtt tggaggcggg 2768701 tgtaaaggaa gtatcgatga agcggagaca gcgaagaaag ctggcgctgt tccgtactta 2768761 tacaggcttt atcacggatg cctgggcttg gtcgattaat tggtccagct tttctatttt 2768821 ttttcgtgcg gttgaaggat caatttggcg gtaatgatgg tggccgcccg gctcttcatc 2768881 cagttcgtcc gcttttttga caatctgctg cagtgtgttt ttatctaatt cgccttcagg 2768941 caaataggaa tctgtatgaa gcaaaatggc tagtgcaatc tcttttgctg ctttcggttc 2769001 ctcgccaagc cgaatcagaa gtttatgcgc ccgttccgcc cctttaatgg catgaatgtc 2769061 atttcttttg tatttctcat aatcccactt tccgtctgta taccattcat aatggccaat 2769121 gtcatgaagc agtgccgctt ttgctgctaa atcaggatta atgtcagcct tcacagacag 2769181 cctgtatgca tgataagcgc aggcaatcgc atgtgccacg ccggaacgct gaagatattt 2769241 ttgtgcaatt ggatgggtga aaacatccat taatgtaacc tttctcatgg aaacccctcc 2769301 tttagatatt tttagaatcc taacataatt tgcagagaaa ctcaattctt atgtcacatc 2769361 attttgatct tcttatcatc attgttatac cctaaaagca acgtttcagt cagtatatgc 2769421 ggctgttcaa taaaatgcgc tggctgcagc cttttgtata aaaaaaagag cagaaaatat 2769481 ctgctctaca aaaactcttt aatatcataa atgcggccgt tttccgtccc tttttctagt 2769541 aaagaaagca gcgtgccggc aataaagtcc ggactgcgaa ggcttcctgt ttcatttaat 2769601 ttccggaatc gttcaatgtg gtggaaatcc tttttcgatg aagaacggat gacggcctgc 2769661 atctcagtgt ccatcactcc aggtgagaac gaaatcatgt tcaccggcag ctcttcatcc 2769721 tcctgttcaa atccgaatgt cctcgtaaac atgtcgagcc cggcttttga actgcaatac 2769781 gcgctccatc ccttatatgg atttttggcg gctcctgaag taatgttgac aaccgtcttt 2769841 ttgccgctgt atgaagcaaa ccgttttgta aacagctgac tcaaaagcac gggcgcagtc 2769901 aggttcagct gataatggcg ctgaagctcg tcaagagacg cttcgccggc acgtttgatc 2769961 ggcgttacca ttccggcgtt attaataagg gtaataccag aataacgatc tgaatcgatg 2770021 gatgagagca atgtttcaaa ttgctgttca gcttcttcga gattgatgag gtctatttga 2770081 tgctgcgtta gttttttgtg agagacatct gttttcgttc tggataaggc atggacttca 2770141 tgcccctttt ctaaagcctg taatgcaatg gcttgaccca gcccttttga cgctccggtg 2770201 atgatataaa gttccattgg aaacctcctt ttccgttatt attgtacggc acctctttta 2770261 cacaacacaa gcacgcggcc tacgccttct tgttttcctg cgctgtgact tttgggatga 2770321 ggaacacgat gcctgcaatt ccgagcagga tcagtacgac atagatcatc ggcagcagca 2770381 atgatgatgt ttcttgttca tcttctgttt ccgttgatga tgtctttgtc attggttttt 2770441 cagcaaaagt aattccaagc tgtttcgact gggccgcaat cgtgttggaa tcctcggcat 2770501 ttgttgatgt aaacaaatct tttatcagct cggcgtcctt gtccttcggt ttatcaaaag 2770561 tgatatcctt ttgttcctca ggcagttctg ttttttcttc atagtaggta tcttcatgca 2770621 aataattcgt atcgatttcg atgtcttttt tctcatactg gtttggcgcg acatctgtat 2770681 tttcttcagt ttgggcagcc gctgcagagg gtatgaaaag ggaaaaggag agcatacaaa 2770741 tcatgatccc cttttccatg ctgcgatcac gcttcatacg tttcatcgct ttctgctgtg 2770801 tgttcagcca tcaaccggat aatcagcggc agagccacgg caatcaccgt aatgatcagc 2770861 agaactgtta ttcccattgt aaacaagtgc ccagtaccgt actggatgtc gatatatact 2770921 ttcgaaaccg gatcttcaaa tgtaaagttc ggcatgatca aatcaataag cggtgcgaca 2770981 tagaatagga tcattgctgc tgaagcaacc cagccaggga ttgatccgaa tctgaatgcc 2771041 gtccggatga aggcagagct tgcgaccagc aatagaatcg taaacaccga ccacttaatc 2771101 gtctgatcgt ccggcagtga ataaatattc aagccgaaca agctgatcat aagtccgaca 2771161 aggatattca gaattccgaa taacgctcct ttgacgagaa gcggtgcgtt ttggtaatac 2771221 gagctgaaat agccgattaa cagactgctg atcaacacaa tgacaaggat gacaaccgga 2771281 ggtaccgtct gaattttttc ttccggaacc tctccgctga ttttaagcgg attcgctaag 2771341 taatcatata catagccatt gttttgcccg tctactaatg tatttccgag tatgccgtat 2771401 acgtcatttc gcacgagttt cgtggaggcg acatttttcc cccagttgtt gtttaaggtg 2771461 tcggctttcg cttgaacatc attaacgctt tgctgcatgt tggttgtgta atcaatgatg 2771521 ccggactggc gatcagacaa tgaacccatc atgtctgaca tttgcagcac ttcctggccg 2771581 accgtatctt ggacactcag tgccatggta ccagacagcc catcgttgct gaacgtcgca 2771641 gattcctgtg ttgcgcccgt tacaagctgt tctgacgctt ttgcggcact ttcagagatt 2771701 ttcgtcagtt cgtcgagaac acctgcttga gagtcacgga tatagccgct gtagtcgtcc 2771761 gcaaatttgg tcatgccgtc gatgaagctg ttaatatcct catctgtttg catcgtgttg 2771821 tttttgagag cttcccagct ggctgattct tcaggtgtga gagccaggac tgattggacg 2771881 ttgccatctt gctcttggat gacttcacct ttaataatag tcaaagagcc tagatccaga 2771941 ttatcattta gcgtagactt atataaattt aaagagttgt aatacttcat caagttagaa 2772001 atattatcag tttcaattct acttgaaaaa attgaactta gtttttcttt ctgatctata 2772061 tagcctctac tctgcaaagt ttgtattatt tcgtcttcca aattgtatat taacctataa 2772121 gcatcattga cattattatc aaaatcaacc aacttttttg ttaagtcacc aatttgatca 2772181 tttaattttg aaactgtttt atttaactct ttaatttctt gatttaactc atcaatatgt 2772241 ttctctagtt tgttgttatg ttcctcttgt ttttcttgaa gtgcattttc tatttcctct 2772301 aattttatcg ctgcttcgtt cagacgtttt tttgcacctg aaatatcagt ttcaccgtca 2772361 gctccgtcac cctgtagccc atcactttga tttgagccat cgttttcatc tgcgagttca 2772421 atcaaagaga aatctgtttt agaggttcct gtattctccg tgtttgtatc ttgttcagga 2772481 acgttttttg aagattcttg atgtttttgt cccgtttcaa tgttagtttg aacatcattt 2772541 tgtgatccat tatcttgagt accctcttct gatgagccag tatcttcatt tgttggctga 2772601 tcatcggatg ttggaatatc attcgacggt tcttcagtat taggagaatc atcggttgat 2772661 ggttcttcag catcgggtgt tgttggtttt tcttgttcag gttcttttaa cccttcagag 2772721 atatctttaa tttcagttgc aacatttttg agctcatccc gctgcttctc taaatccaat 2772781 tttatatctt caatatcttc cttatctgtg tcatctttat tatcagatgt gtcttctcca 2772841 tcttcctttt cgtcgctttc cttaggttta agtaaactaa ggcggttctt cccgatattc 2772901 tcttgcaatt gatttaaatt ttgatattta atagcttcat attgactttt atatcgagat 2772961 agaaatgcat taaacatgtc attctcaatt tttttcatac ccatttcttg caatggcact 2773021 tgattttgcc ttaacttttc agcattgttc aacgcaaggt ttgtcagtcc tatttgtgtc 2773081 ttcgcttggc cgatcccggt tgccaatccg ctcatgcgtt cgctgaactg attcgccttt 2773141 tgctgtgcct ggatggcatc cagacctgtc cggatttgct gctgtgttga atcctgggct 2773201 gccaaaagca gctttttctg attctcttga tattctttgt acctttcaac tgtatcaatg 2773261 aattctttca gcgtgttttt ggcttcctcc gccgtagaag ctttttcttt tgtcgtgcct 2773321 tgcgcttcat tcattgattt cttcagctca tcgattaagt ctttttgctg tttgatttca 2773381 cctgctaaat cattagagct tggtttgtaa aagttgtaca tgacattctg gaattcagat 2773441 tctttattga cgatcttgtc aaattctcct ctgatgttgt ccactttttg cgaaacaaaa 2773501 ttccagtata aggccgacat ttttttgttc attgtctttt gggcatcctc aagctcacgc 2773561 tgaacttttt ctttgttaac cgcattcagg ttatcttgaa tgctgaattc gagcgttgcc 2773621 ttttgaggat ggtctttgtc atagctcaaa atgttttttg agaagtctga gggaatgtag 2773681 acaatcgcat cgtatttctt tgaagcgaga ccggtctcgg ccgcgcttcg gtttacgacc 2773741 gtccacgaat aatcaggacg ttcacccaga acggccgcta cttccttgcc gaactgggcg 2773801 gatttgtcct cttcatcaga ctttacctca tcactcaata cgcctgtgtc ttcattcacc 2773861 accgcgattt gccgggtaga attgactgct tttttcgttg ggtcgtctcc gataaatcgg 2773921 aaaaacaaca ccggcagcag caaaatgatg atgacggcgg atattaactt gatcaagctt 2773981 tttcgttgtt ctgtcatcta gcactctccc tttcagcaga acataaagga atttgaactt 2774041 tttgctcctt cccgttttcc acaacatatc cgaagcccgg ctgaatctca ggctcctgtc 2774101 tttggtacgg gagaggaatg acattttgct cagacttttt catcagcaga atcgcgtggc 2774161 ggatttgctt catctcagtc gtcaaggagt catagccttt tgagaattcg ctgtggtttc 2774221 cgcccgggat aaagctgaac ccaagatgag cgtatgattt catgaagtta gcgagacgat 2774281 cttgtattct cgtatcaatc gtctgctgga atctcgttat cccgtcaatc atcagcacga 2774341 cttgtgagaa tcgcagattt tgtgcgtctc cttggcggac ggcttctaca tacatggctt 2774401 ctcttgtttt gaaaatgtct tctgctgttt caatccactg ctcaatatct tctttcgttt 2774461 ccaaatatga aacatctgat tccttcgcat aatgagataa gccgcggtca atcgagtcaa 2774521 acaggccgat catttcggtt tcatcatcaa tcagatgttc aagcatgact tttaggacgt 2774581 ttgttttccc gcgctgagtt tggcctaaaa tcaggcagtg cttatgcttg cccaaatcaa 2774641 aatagactgg gctgactgtt tcttcatgaa gcccgatcgg tacagataaa ggcttgcgtt 2774701 ccagcttgaa gcggatagac aattctctcg tcgacaagct ctcaggcagc atcggaatcg 2774761 gtgccggctg ctccattgaa gcaaatcgcc cttgaagttt ctgtacgtct gatttcagct 2774821 cgttgaacat gccgatatca tcatcggcgt caacaggcag gaacatttgc gcgaaataaa 2774881 gctcttcctt ttgaatgatg acgcgtcccg gaatcggctc aagattgaat ttcggacggc 2774941 cgtaaatgga atatccttct gattgatcca tgagataatg gacaatcttt gttttcaagt 2775001 tatttaacaa tgactggcgg acagcattca cccgcgttgc tgtcagcata aagtagatac 2775061 ccaagctttg tccgtctctg gaaagctgga caaattccga ttcaagctca tgcatctcat 2775121 ccttgacaat gtcaaagttg tcaatggtga taaaaatgaa tggaagctct tcttcgctca 2775181 gcgcattgta cattttgatg tggctgattt ctttttcccg gaacaaacgt ttacggcggt 2775241 caatttcttc tttgatgcga atcatgaact tttcaatttt ccttgactgg tccatcagga 2775301 agtaatccgc ggtatgcggg agcttcgcta atggcagcag cgttccgttt ccgaaatcaa 2775361 agatatagac atgaagctct tcaggtgtgt atacgtccgc aaaactcatc aggaacgttg 2775421 cggctgcaat cgattttccg tagcccgaag agccgaagat gccgatattt ccatcttcca 2775481 tcatcttata agcaattggc gcctgtcttt gcagatcagg ttcatcgaca tacgcaaagt 2775541 ggaaatggtc tttttcgttt gaagggaaaa gagtgcgcgg aatacgttcc gcaagcggcg 2775601 gcagccaagg gcttggcagc ttctcgattc ccatttcatc ttggatgcgt tcaatttcgt 2775661 caactacagc ttcgatttcg gtttgaacgt cttttttcgc gttatcttcg gtatcaacct 2775721 cagaaagcgg gatcagaccc gtatctgtga cgatcgcgat ttcatcctcg gtaccgtaga 2775781 cttcctctaa gtaaggcgcc ccgctccatg cagattggaa cagctcatac acttcattgt 2775841 ttccgacctg caaatagccg cggcctgtta cggtaatgtt tgcggcatcg ctgtttttca 2775901 aaatttcttt actgtcggtg gcatcctgga ccttgagcgc tactttaaag cgcgagttac 2775961 tccagatctg gtcgtcgatg atgccgcctg gcttctgtgt cgccaaaatc aaatgaacgc 2776021 cgaggcttcg tccgatacgc gcggcactga caagctccct gataaaatca ggctcctcgc 2776081 ttttcagctc ggcaaactca tcagaaatta agaacaagtg aggcatcgcc acttctgctt 2776141 tcccttgctt gtatagcttt gtatagtcat tgatgtgatt gacttgatac tggtcaaaca 2776201 ggcgctgcct tttttttagc tcgcttttaa tggaagcaag cgcacgcata ctgaagtttt 2776261 tgcttccttc aatatttgtg atcgtgccga ggaggtgggg aatgttacgg aacggctgcg 2776321 ccattcctcc gcctttatag tcaattagta agaaagccgc ttcatgcgga tgaaaatgca 2776381 ctgcaagtga caagatgtag gtctggagaa attcactttt ccctgatccc gttgtccccg 2776441 caagcaagcc gtgcggaccg tgtgcttttt cgtgaaggtt cagatacaca atgtcatctt 2776501 tccctttata gccgatcggc actgacagcg acttcgacga ttcacttgtc agccatcttt 2776561 gctgaatgcc gatttctttt acttccttcg catgaaaaag ctccaggaac gataccgttt 2776621 ccggaatgga attcgtaatg ccgacctggt ggttcagcgt ccgcagtgtg cgtgaaaacc 2776681 gttcgttatc ctcacgctga tgatgatcga gacggaacgg aattcttacc gcttttttct 2776741 tttgtattaa aatgtcgcct tcatgctcat taatgtagcg gacaagagtt gtaatgtttt 2776801 ccgacaagct ttcctttgtt tctgcagcga caattgtcga gatgcccaga tgctcatgct 2776861 gcccttctaa atattcgaga atgacatgct cagagatcag ctgctgattc gtgatgacaa 2776921 atacaaaatg cggtttgaac tgcagttttt ctttgtcatc ttcgagatca cgctctctga 2776981 tcaattcgta aagtgaagac aggagctgat ctcgggtttg ctcattataa ataaatcctt 2777041 ttgcataaat atggggcatt tgaaattgcg gaagccactt catccactcc cagtctttat 2777101 actcttcttc atgaaaaata aatacgaaac gcaaatcgtg atagctgtta aagaacgaca 2777161 gctgtccgat tagctggtga atctcatttt tcacaatttg tgatttaccg acaagcccca 2777221 tcggaccttc tgccaaatcg accgtcaccg gcgcattacg gatatcttta tagacgcgtt 2777281 gcatgtgctg cgatttctcc atgaggtcat cgatatcacg attcgccaag tctccgccac 2777341 tcatattgat ttcatagctt gacggaactg ttcccgtccc aagccgcagc tggagataat 2777401 ccttgctttc aagtgatttt tcccagatcc ggtcactgat ttcacttgtt aagtatttca 2777461 tttgttcaaa tgaaggaaag tgaaattcaa gaacctgctt ttgcttttca gcaagtgcct 2777521 gaagctcttt ccgcttattg tctaagtaaa gcttatatac acgctcccgt ttttcctcgc 2777581 gttttttccg ctggttttta tcacggaaat attgcactgt cgaggtaatg agagtcatca 2777641 taaacatcgc caaagaaacg agtataaata tgccgcgcgg ctggatgatg gcaactacgc 2777701 ccatcacgat cagcatcaca agcggaggca ggatgacgag ccacagccct ctgttggttt 2777761 gatcgctctc ctgagaggga aaactgaaag aaacgcggtc atccggcaga tcgtatacca 2777821 tccgcggcgt tcttctgtac tgcggatatt ttttctgcat ctctgtactc ggtttgaccg 2777881 tttctgttaa cgctgtttca aactgggcat aatgaacaat ttctaaaagg tcttgttccg 2777941 tcaccctcat ttgcgtgaag ttccagaata tttcatcccc cggcttgagc ggcgtattgg 2778001 cgttgatttt ctctccgttc aagaagatcg ttccgctttc agggcggacc gaccagctgc 2778061 cgcctgcacg gagcaaagaa aacgtgcttt gttctgcaaa tgcaaaatct tgcggattca 2778121 gataaatatc tgcattcgtt ttttctgagg aacatacaat ttcatcccga tttcccgtaa 2778181 aataaacgga tttctcaggt tcactgcccg tcaatatcaa gcgtatatcc tgctgatccg 2778241 tttggagagt aaatgatata tccgtctcaa tcgtgccgag acaatcattt cccaggaaaa 2778301 cttcgtattg gccgccggat tcctttcttt taagagaaat cactccgcta ttaaatggaa 2778361 tggtgctgat cgtaacagaa tccttcacat caggccctat ggtcaccgga tgagacgacg 2778421 ggaggttaga cagatttaat ttttgaacgt tattttggta aaaaacccat aatagactca 2778481 aatggcgaac ccccttacgg ccgaatggca gcatgcgatg acctgcgctt catgtctcac 2778541 gttatttgtc atcttttttc tcatctttct tttctgtttc ttttttctcg tcttcttttt 2778601 ccttctgttc ttcttttttc gctttttcct cggctgcggc tttttcttct gccgctttct 2778661 cttctgcttg tttttcttcg tctgtttgtg tctgttcttc gcttgtatcg actaacgatg 2778721 tttcagaatt agactgttta ttttcttgac gttctttttg ggctttttca agctcactat 2778781 ttactgaatc aagttctttt tgtatgtctt catcatttgt atcctcagat aaaagctgct 2778841 gtttatattt agctagggca aagtaaatat aatcattgta ttccagctta cggccgatac 2778901 tgatcgcttc tttgtattct cctcgaccat aatcaatcca atataagaaa tgctgagggt 2778961 ctgattgaag ggtgactaaa ttattttcta tatttttggt ttttgcactc cccaggtttt 2779021 cgacctcaac ataggacgtc gccagctgat actgcaccga ttcaggcagg ctttccgcat 2779081 cgtacttgga cagtgtgctg atgacttcac tgtactgctt gtttaagaac gcacggttgc 2779141 tgtccactat cgcctggtgc tttggctgcg cgaaaaataa ggcgtacatc gaataaataa 2779201 gtgccggtac aagcaaaaca atgagcccca ggccgatata tcgctggatg ttccacttct 2779261 ttctcgggat atgtatgtat gtttttgctt tggcttcgag ctcatcaata tgggtttgaa 2779321 tcagctcgag caaatcatca taggattcag catctaatat cgcctttgcc tctgcggaga 2779381 acgtcagcgt ttcattgaat ttcaggtagt cttcaaacgc aaaagcgccg tcaactgcca 2779441 aagccgctgc cgctttcagc tcctgccata ctctttcctc atcacgctcg taaggaggaa 2779501 tgctttcttt tactccataa tggagaaaat aaggcgtaag ccctttatcg aatacaatgt 2779561 tttcaggagc gacaatcaaa ttcagcctcg acagattgtg ctgctgtacg gcttgaacaa 2779621 gctgataggc aaactgccat ttactttttt tatccttagc tttcatgaag cggaatgctt 2779681 tataggagga gggaggttgg attgtgatga ttacttcatc atccgtcaca tcgatttctt 2779741 tatgaaaaaa tggatttata tctttgatca cgttagcttc aagaccgtcg agaagcttta 2779801 ttttttcccg ttgaaaggta aatgtatagc cggcatctgt tttctcggca acagcttcta 2779861 attggttttc taaatatgat ttttgttcac ctgacattca accagatcct ttcataatat 2779921 ttcaagccgg tctccgtttg taatgccgca atcagacagc ttgcattctc cggaaaacac 2779981 cttatccttg ttcaccactc tgatccagtg cccttcgcgc ggaggcatag atacgctttg 2780041 ggcctgccaa gcaatatcaa ttactttttt caccgggtgg taatctgaca atctgagatc 2780101 aaagacactg ccgttataat gtttcaaatc tattgtaata tcaatataca tttaggatca 2780161 cccttacata gaaagagcgc cgtcttcttt tgaatcaggc gctccttccc tttcatactg 2780221 ttatccgcgg atttgatttg cgatgtcttg gtcagtagac tcaagtgtat ttgctgtttg 2780281 atcaagctgc tgattcacat cttgaagcaa atctgacatt ttgataaatg aaggtttgag 2780341 ctgctcgtat tgatctgcga acgcttcgct tgaagcacct tcccacatgc ttttcaaatc 2780401 agagatcatt cggtttaaac gatcaacctg atttaatact tcttggcttt caacgccgta 2780461 ttgcttcgcc atcgctctta gctcttcggg tgtgacacga attaatcctg ccatattcct 2780521 cattacctcc tgtgccatca gcctaaatat gggctaattc acttattttt agaacgtcat 2780581 tattataaaa acagtttttc ggcatagtca aacaaatatg ttttaatttt acaaaatgag 2780641 tccaatggtt taccccgaat cactcaaaaa tgacatatac tgtaaagtaa ataggtttat 2780701 tttcttaatc ttctcttcat tctccgaata atccaaaaga cccaaataac tctccaactc 2780761 ccaaaaaaaa cctttcagaa aatttgatgc tacagcacca tttctgaaag gttcagtttt 2780821 ttctttcctt aattagtctt gcctccgatg actttcttag aagattaata ggataagctg 2780881 tcgtattata tgagacatac actgtcctgc aaaaaggcga ttacaccgcc aaatgtatat 2780941 agaacgtttc tctcatgaaa ttgttttttt gcttctgttc tttgttgttg attttcacaa 2781001 acaacaacaa tcataataaa aggaagggga tgagatgtca aagagaaatc aagcacgaaa 2781061 agtagggaga tttatgacca tgccgaatga tccgtttaaa tatagttttg acagacttga 2781121 agatgtggct gatcatatca gcgacgttct gcggtgcccg atcaccatag aggatgttaa 2781181 ccacaagctg cttgcctaca gtacacacag cgactgcaca gaccctgccc ggacgtctac 2781241 cattattggc agaagggtac cggagaaggt gattaacaag ctgtggaaag acgggacaat 2781301 tcctgctctc ttaaaaacgg accagccgat cagagtcaag caaatcgatg aagtcgggct 2781361 gagcaatcgc gtcgctattt cgatttggaa aaacaagcaa gtacttggct tcatatgggc 2781421 gcttgagatc caaaaaacat tgtccgatga agatctgctg acattgcaaa tggcagcaaa 2781481 agcagtgaaa aacaagcttc tcaaacttca aatcagaaaa acgaaaaatg aagaacgcag 2781541 ccaagaattt ttctggaaaa tgctgaccgg acacatccat caggaggatg atatggcgga 2781601 tgggttccat aagcttggaa tggccgctcc ttcagagttt tccgttatga tcatccgcat 2781661 aaatggcgag ctgactgaaa aaatcgaaca gcagctgcaa tatttacagg aaacgaccca 2781721 gcaggtttac gtgctgctgg cgaccgtaga ttccaatgaa cttattatat taacctcacc 2781781 caaaacagat catccttttc aagatttaaa acagtttgct ttaagtacgc aaaaacagct 2781841 gaaggagcgg tataaaatag aagacgtttc tatcgctttt ggcggaatat acaactctat 2781901 ttcttttgtc tcccgctcct atcaggaagc attgtccgtc ttaaaaacga aggaacggtt 2781961 cgctgaagag accaaacatc ttttcagctt ttctgagtta ggcatttatc aatacttaga 2782021 tgtcttaaat gaaaaacgga aacaggcggg ccattataat tactcgcttt ccaaactgga 2782081 acaatatgac cgggatcacc agtcaaatat ggtagagacg ctagagcgct ttattgaagc 2782141 ggacagcaac gtgaataccg cttccaagct gttaaatata cacgttaata cgttgaatta 2782201 ccgactcaag cggatcagcc agatcgctga aattgatttg aaaaatgtga atcaaaaatt 2782261 caccatctat ttagatatca aacttcggca catggatttg tgaaatttca caaatccatg 2782321 tttttttatt ttcttaatca aacaaagaat tttccaaaat atcaagctac actaaaaata 2782381 tcacatatac aggaggagac agatatgatc ataggggttc ctaaagagat aaaaaacaat 2782441 gaaaaccgtg tcgcattaac acccgggggc gtttctcagc tcatttcaaa cggccaccgg 2782501 gtgctggttg aaacaggcgc gggccttgga agcggatttg aaaatgaagc ctatgagtca 2782561 gcaggagcgg aaatcattgc tgatccgaag caggtctggg acgccgaaat ggtcatgaaa 2782621 gtaaaagaac cgctgccgga agaatatgtt tattttcgca aaggacttgt gctgtttacg 2782681 taccttcatt tagcagctga gcctgagctt gcacaggcct tgaaggataa aggagtaact 2782741 gccatcgcat atgaaacggt cagtgaaggc cggacattgc ctcttctgac gccaatgtca 2782801 gaggttgcgg gcagaatggc agcgcaaatc ggcgctcaat tcttagaaaa gcctaaaggc 2782861 ggaaaaggca ttctgcttgc cggggtgcct ggcgtttccc gcggaaaagt aacaattatc 2782921 ggaggaggcg ttgtcgggac aaacgcggcg aaaatggctg tcggcctcgg tgcagatgtg 2782981 acgatcattg acttaaacgc agaccgcttg cgccagcttg atgacatctt cggccatcag 2783041 attaaaacgt taatttctaa tccggtcaat attgctgatg ctgtggcgga agcggatctc 2783101 ctcatttgcg cggtattaat tccgggtgct aaagctccga ctcttgtcac tgaggaaatg 2783161 gtaaaacaaa tgaaacccgg ttcagttatt gttgatgtag cgatcgacca aggcggcatc 2783221 gtcgaaactg tcgaccatat cacaacacat gatcagccaa catatgaaaa acacggggtt 2783281 gtgcattatg ctgtagcgaa catgccaggc gcagtccctc gtacatcaac aatcgccctg 2783341 actaacgtta ctgttccata cgcgctgcaa atcgcgaaca aaggggcagt aaaagcgctc 2783401 gcagacaata cggcactgag agcgggttta aacaccgcaa acggacacgt gacctatgaa 2783461 gctgtagcaa gagatctagg ctatgagtat gttcctgccg agaaagcttt acaggatgaa 2783521 tcatctgtgg cgggtgctta attcacaata agcttgcaga aagatttctg caggcttttt 2783581 tattttttaa aaggaaaaaa gagaccattt cacgaattat gactatgaag ttgatcataa 2783641 aggaggattc atatggctgt tcagcaatat ggcgtgttaa aaggcatagt attagacatg 2783701 aagcgggaaa cagatgatga cagtcctcat ttccaagtca aaatgctcgg tgaagagaat 2783761 acgtattaca ggtgcgccat caatgtgatg tccagttctg aggaatctga agtattgtat 2783821 ttggctgacg atcagtttga ttcgggctca attaccatcc ttccgaacat gccgtatgga 2783881 tatacaagga tcaatgaagc aaaccgtgaa gtggcactgg attatgtgcg gggcaatttg 2783941 tttgacccgc gggaaatgaa gcctttgcct catgaaatca cgggacctga taatgattta 2784001 aatgatttta ttgaaaccta tatgaagaaa gcacaagatg agaaaacgcc ggtttatata 2784061 ttcggttcaa aattcggccc tgaacaggct gcagataaaa tattcggctt taccccgact 2784121 aacggaatgc acaatatcca tatgaatcaa gggaatgcaa tggatacccg ctggaaaaaa 2784181 gacaacggct cttggcatga cgggggtatt ctgattcagt ttgcagatca gtgggccgct 2784241 gtgtttttag cgtttttatc ccaatcttgg tgtaccgatg aaaacggaaa ccctgtcaga 2784301 gattgtgatc atacccaaac gtctgcgtaa gatagaaaaa gagactgcgg caagcagtct 2784361 ctttttgata agattacaca ttttcaacag tctttaggct gtttggcctc atatcgctcc 2784421 aatgcgattg gatatagtcc aaacaagctt cacgcccttt ttgctcatga acgactgtcc 2784481 agccgctcgg cacatctata aaacccggcc atagggaata ttggccttct tcattgacca 2784541 gcaccaaata tgtgccatcc gcattttcaa aaggatttgc cattctattt ctcctccctt 2784601 atttattcaa ctcttccaat ttgacagcga gaaccttgcc gatttgagcc agaggttcag 2784661 gctgacataa atctttatga cggcagtcga tgtcgatttg ttcaatctgt ccgttaatat 2784721 aaggcttcca cgagtcaggt tcaatcgggt caaaccattc aggaatgatt gttgatctga 2784781 aaaacaaaac atttccgcgg aaggttttcg gcttatagga acctaaaatg ccgacagaat 2784841 ttacatacgt attcttcaaa tttaaaatga ccgtttcatc caggctcgca agcgcactgc 2784901 cgtcacggcg aagaatctca atcgccgctt caaaatctag cggtttttcc cctaagctgt 2784961 ctggatcata cccgcctaac gccagaaggg caataagcgc ttcctcatca tccggtgcct 2785021 cttttatagg aaggaagtgg ttcggatagg cgtccagcat caccaacagg gatacttctt 2785081 ctccttgatt ttgcagctgg gtagccatcg cttgaacgac attcccgccc agggaccagc 2785141 ccagcagatg gtacgggcct tttggctgga ccgttcggat ttgtttaatg taatcggcag 2785201 ccatgtcatc aagtgttttc ggaagctcct cgcgctgccc gattccccgt gcctgcaagc 2785261 cgtagatcgg ataatctgtt cctatattgg tcatcaaacc ggcataacac cagctgagcc 2785321 cccctgccgg atgaacacag aataaaggag gcttgtctcc gcttgttcgg agcggcagca 2785381 gaacgtcaag agcgctttgg cttgatccca tttcaagtct ttcagcgagc ccggctacag 2785441 taggtgcttc gaacaagttg ccgatgctga gttcaacgcc gagcgcttca cgaatgcggc 2785501 tcatgagctg tacagcaagc aaggaatgtc cgcctaaatc aaagaaacgg tcatcaatgc 2785561 cgacacgcgg caagtgaagc acctccataa agaggtcaca gagaatttct tcctgcggcg 2785621 ttctcggtcc tcgtcctgtc actgccgctg cgaaatccgg agcgggcagc gctttacgat 2785681 caagctttcc attcggtgtc agcggcaatt ctttcatcgt cacaaaggca gcaggcacca 2785741 tgtaatccgg cagtctctca gcagcatatc tgcgcagttc cgccgtatca aatgtttctt 2785801 ccgaagggat gacataagct gctaaccgtt tatctcccgg ctgatcctca cgaacgatca 2785861 ctgccgcatc ttcaagctgc ggatgctgaa caagcgcggc ttcaatttct cccaattcaa 2785921 tccggaatcc ccgaattttc acttgatggt ctgcacggcc gacatagtcg agagaaccgt 2785981 cagcgcggag gcgggccaca tccccagtgc ggtacatccg ggtgcctgga ggaccgaacg 2786041 gatcagctat gaagcgttca gatgttaaac caggccggcc tagataacct cgtgctaacc 2786101 ccgctcctga tacatacagc tctccggcaa cacccggcgg gaccggctgc aggcgttcat 2786161 ccagcacgta tacaccaaga tcgggaatgc cgcagccgat caagctgttt gcccgtaaag 2786221 ctgccatgct tcggtctaat tcgatatagc tcacatgcac cgtcgtttct gtaataccat 2786281 acatattgat aagctgcggt ctattttcag ggtggcggtt gtaccaatcc tctaaacggc 2786341 tgagttcaag cgcttctccg ccaaaaatga catagcgcag actgagtgcc tgtccgagat 2786401 ccggctgttc ccgttccgcc tgcataaact gatagaaagc agacggtgtc tggttcagaa 2786461 cagtcacccc ctctttgaca agcaggcgca gaaacgcttc tggcgatctg ctgacgtggt 2786521 gaggcacgat tacaagacgt ccgccatgca gcagaggacc ccagatctcc cacaccgaaa 2786581 aatcaaacgc ataggaatgg aacatggtcc agatatcacc tgagctgaaa cggaaccagt 2786641 gctcggtcgc tgcaaataaa cgtgttacat tttggtgagg aatcatcaca ccttttggaa 2786701 cacctgttga gccggatgta taaatgacat atgccgtatt caaaggggaa agcggctgag 2786761 tcctatcctt attttttgga ttacctgcag ggtacgtgtt tagtttctct gccagctcgg 2786821 gatcatccag cacgattttc ggcacgtttt caactggcgg aatgtgattt gcagctttag 2786881 tgttcgtcat gataaacgca ggctgtgcat cttttagcat aaaagcaatt cgatcagccg 2786941 gataatccgg atcaagaggg agataagctg ccccggcctt tagcaccgcc aataggccga 2787001 cagccatttc caacgatcgg ggcagtgcca atgccacaaa ttgctccggc ccgacacctt 2787061 cactaatcat cattcgggca agccggtttg ctctttcatt cagctctgca tagctcagtt 2787121 cctgattttc atatacaacg gcaatggcat caggacgtaa agcagcctgc ttctcaaatt 2787181 gctctggcaa acatgcgtgc ggaatctttt cagatacact ttgccaatca gtcaccatgc 2787241 tgctgtgttc ctctggcgca agaatatcca gatttccgat ttgctcgtca ggatcagact 2787301 cggcagcctc caacaggcgc atcaatcggt cagcaagagc ctgagcagtt tcccgtttga 2787361 aaagatcagt gctgtattca agcagtcctt ccattccgtt tggtgtcccg tcagcaaggc 2787421 gatcttcact aatttccagc gtcaaatcaa acttggcaga accgacactg ttgattcgca 2787481 ggctgctctc catatcagga agatgcagtt cagcgtccgg tgtgttttgg aacgcaagca 2787541 tgatttggaa taaaggatgc gtcgcacgcg aacgagccgg attgagcacc tctacaagtc 2787601 tctcaaacgg cagatcctga ttgtcatagg cggccagatt cacttcccgt actctgtcta 2787661 gaagctcacg aaagcttggg tcaccggacg tatcagttct gagcaccaat gtattaatga 2787721 acagccctac aagatcgccc agcgcatcat cattccgtcc cgcgatcgga ctgccgatcg 2787781 gaatgtcggt gcccgccccg agccttgtca ataaagcggc gagaccggat tgaagcacca 2787841 taaacaggct caccctattt gcgcgagcca gctcctgcaa tcgcttgtga aactcgggct 2787901 caatacgaaa atgaatcgta tctccatcat gactcggctc agccggacgt gaataatcgg 2787961 ttggcagttc aagctgatca ggcaggtttt tcaaggtttc tttccagaaa gcaagctgtc 2788021 cggcaatcaa gctatttgga tcatcctcgt ttccaagcag ttcttgctgc caaagcgcat 2788081 agtctgcata ctgcacagca agaggcgccc attcgggaga tcgtccgtgg cagcgagccg 2788141 cataagctgt cccaaggtct ctggtcagcg gtgttaagga ccagccgtcc ccgacaatat 2788201 gatggacgag aagaagcagc acgtactcgt caggaccgat cacaaaaagc tcggcacgaa 2788261 aagcaggttc agctgcaaga tcaaagctgt agcgtacagc ttcggcaagc cgatcagaaa 2788321 gctccttctc agcaatttca gtaacatgta actcgggaca ggctcgatcg gcatctaaaa 2788381 tatgctgata ggatgtcccc tgtgattcag ggaagatcgt ccgaagactt tcatgacggc 2788441 agacgaggtc ataaagtgcc gctttcagca atccttgatc caactcacct gacaaacgga 2788501 cagcaaccgg aatattataa gtaggactcg gtccttccag acaatgcagg aaccatagcc 2788561 ggcgctgggc aaatgagagc gggatctttt caggccgctc agctctctgc aaagcgggac 2788621 atgcactctg cgccaaatca agatgggcag cgagtccggc tactgtcggt tcgtcaaaga 2788681 gcttggcgat accaagttcg gctcccatta cctcgcgaat gcggctcatc agacgggctg 2788741 caagaagaga atggccccca agctcgaaga aactgtcatc gataccgacg cgtgccaaac 2788801 cgagaacctc tgcaaacaag tcacacaata tctcttcctg aggagtccgc ggggcccgat 2788861 cactgacaga tgtgctgaag tctggtgccg gcagtgcttt ccggtcaagc ttgccattag 2788921 gtgttaacgg cagctcgtcc atctccacaa acgccgacgg taccatataa tcaggaagac 2788981 tagcccccat ataacgacga agctctgcag tatcaatagc agcatcagcg actacataag 2789041 ccgccaatcg tttgtctccc ggctgatctt cccgtacgac aaccgcggcc tgttcaatgt 2789101 gcgggtgatt ggcaagcacg gcatcaattt ctccaagttc aattcggaat ccgcgaattt 2789161 tgatttgatg atccgcccgc ccgatataat ccaaagaccc atcggcgcgc cagcgggcct 2789221 ggtctccggt ccgatacatc cgagttcccg gcggtccgta tggatctgca acgaagcgct 2789281 ccgccgttaa atcaggacga tggaaataac ctctggccaa gccggttcct gcaatataaa 2789341 gctctccgac aacgcccggc ggcaccggct gcaatccatt atcaagcaca tacacctgcg 2789401 tgttccaaat cggtttccca atcggaggaa cgcccttcag cccttcttca agaaaagctg 2789461 cggcagacca aatcgttgtt tcagtgggac cgtataagtt cgtgactgaa caatgaaggt 2789521 cttgaagttc ctgcaaaaga ccgctcggca gcgcctcgcc tcctacaagc actctaagcc 2789581 cccgaagttt ctcaggttca ctcgttacca aagcgtgcca cagtgtcggt gtcgcctgca 2789641 taatgttaat atcgaaattt tcaatcattt gagctaatgc ctgcggctca cggatcgttt 2789701 ctttctttgc gatcacgatt tgcgctccgc taatcagcgg aagatataac tccaatgctg 2789761 aaatatcaaa agcgacagtc gtcacagcca acagcctgtc ttcttctcct agagaaaatg 2789821 cctcctgcat agacagcaga aaattgctta agcttttctg tgtcacaacg actcccttcg 2789881 gtcttcctgt tgatcctgag gtatagatga tatacgcagg atggtcaagc gaaaccgata 2789941 catcctgatt ttccggcgaa tagcgtttta taatctcctg tgtaacagcc tgatcaagca 2790001 caagctcagg tacagccagg tcatcaggca gactggctgc tatttcctca gtcgttatga 2790061 tgcatgaagg tttcgcatcc tccagcatgt aagaaatgcg gtcggctgga aactccggat 2790121 caagggggag atacgccgca ccagtcttga gcacaccaag cattgaagcc accatctcag 2790181 gggaacgcgg cagcgccaaa gcgacaaatt gctccggacc aatccctttt tcgatcaaca 2790241 gacgcgcgag gcggtttgcc tcttcattga gctttcgata gttgacttga atgtcatcac 2790301 acatgagagc gatacgttct ggcgtaagaa ctgcctgctt ttcgaacatg tcctgaaggc 2790361 tgaccagctt ctcggatttt gccgtctcat tccatttaga aatgactttt tctttctcct 2790421 ctggcaacag aagctccatt tgcccaatca gcatgtcctc tccggcagaa gccgtttgca 2790481 gcagctgcaa aatacgctgc tgatgaagct taatatcaga ctcactgtat acctcgggat 2790541 tcgcatcaac atcaattcgc agcccgctgc cgtctgttct gtcatataca ttgattgata 2790601 gatcatcaac aggaccggct gaaagattat gcgttgtgcc ccggacgccg gcaaagtcga 2790661 gaccgtaatc aaacggcata agattgattt gagggccaaa taatctatga ttttctccta 2790721 tcaatttcag atcgcgccta agctcttcat ggcgatactt atgatgtcgc cgaatactgc 2790781 ggatttcccg ggaaatttgc tgaatcagtt cagaaaagct catcgaagag cttaccgtca 2790841 gccggagcgg gagaaggttc atcaccatag ccggtacatt cagtgacgcg gaccctatcc 2790901 gacccatcat gggcaggccg agcacaacat cctcagagcc ggtcatacgg tgcacataaa 2790961 cagctgacac cgcaatcatg acttcatgcc agcttcctga gaaatagcgc gccgcttctt 2791021 ttaacgcgtt tacatcagac ggaggcagat atgccgtatg acgaagaaaa ctgttagatg 2791081 ttcttggcgc ccgatcagcc aagctcacaa cttcaggtgc atctgcaaaa cggtccagcc 2791141 agaattgacg atccttctca tactgctctg atccgcgata atctgtatcc tcctccaaaa 2791201 tggcctggag agacccaaag gaacggcttt tagctgtttg tccttttata agggcagtat 2791261 atgtacttgc cacacgctgg gctatcaggg aaaaaccgaa gccgtcgatc gctatatggt 2791321 gaatgcgctg ataccaaaag aaacgatcag gcccggcaat aaacagagct tcattgaaca 2791381 aaggggcata ccctaaatca accggctttg ctaaatcagc tttcatccag tttaatgctg 2791441 ttttttccgg atcaggctca gagctgacgt caatgacgtg cagctgtaca tccggagacg 2791501 ggtttatcat ctgccaaggc ccgtccatat tttcaccgaa gcggacatgc agcgattccg 2791561 cttccttgat cacgtgccgc aaagcttctt caaaaagagc aatattgact ggtccattga 2791621 tttctatata ttccgctgta ttgtagattg gattgtccgg atcaagctgc tgagcaaacc 2791681 atatgccagt ttgcgccccg gtcaaagaat attgaagatc ttttgtatca ggcatccgtt 2791741 tgtttaccct ccttttataa ataatccgcg tttggcagca cttgctggct gcgagttgtg 2791801 agcaatttct gccattcttc gatcgttggg cgttcagcca attccacgaa agtcacctct 2791861 gccccttcac ggcgccattg ttccaccaat gtcatgatcc ttaccgaatc aagaccacga 2791921 tcgagcaaat cctcttgatc tgtgatgtct tccggtgttt cttgtagaag ctcagcaatt 2791981 tgtttacgga tattctcaca tgtaaacacg ttctttttgc cagtgtttgc tgacgttttt 2792041 tgaacgtctg ccggcgcatt ctgcagctga tcaagaagac tgtcagtcat cacggtaaac 2792101 gcacagcgtc cagccgcata ttccagcgcc atttgatgtt tttctaatga aaaatcagca 2792161 actgcatctc ccacaaaaaa ggctttaata tcctccataa atgcttcaca tgctgtaaca 2792221 agacagccga tatgggcgta aattcctgta atgatcagct gatcgcgtcc ctctttgcgc 2792281 atcatttcaa gcagattcgt tctcttaaac gcgctgtatc tccattttgt cagcacaaga 2792341 tcatcatcct ctggtgccag ctcggttata attttctcct cataaggacc gctgtttaat 2792401 cccgggcccc aaaagtctgt cagcagcgca cggtcatccg gattttggct tcccggctgt 2792461 gcggtataga caacaggaat cccaagctga acacattgat tcttcagctt tcgtatattc 2792521 gctgaaagct ctgttaccgg agacgctccc gctgtgaaag catcaacaaa atagttttgc 2792581 atatcgtgta ttaacaagac agcccgattc ggatcaggca cccatgatac tttgttttgc 2792641 ggcatatcag atgctgtcgg catttgatac ggctgaatgg caggtatagc catatgaaca 2792701 cttcctctca aattgttgtt ttatttttta aatcctgcaa gaagcttctc ggaaatggct 2792761 tcacggagcg cttttttgct gacttttcct actcctgtct gcgggaagga ttcgacaaat 2792821 tcaactcgat cagggatttt atatgccgcc agtccgcgct ctctcaaaaa tgctttaagc 2792881 tctgcggctt ttggggcttc atcccgggga ataatgaaca cacaagatct ttcgccaaga 2792941 aattgatcag gcatggagac cattgccgca tcatggacag ccggatgcgc cagcagatga 2793001 ttttctacct cttcagccgc aaccttttct cctccacggt taatttgatc cttcgcccgg 2793061 ccttcaacga caatatagcc gtctcgtgtc agcctgacga tatcacccgt acggtaaaaa 2793121 ccgtcctcag taaatgaagc ggcgttatgc tcttctgcct tatagtaacc tcgaattgta 2793181 tacggccccc gcgtcagcag atggcctgtt tcaccaggtt ttacgtcgcg atcatgatca 2793241 tcccaaacac gcatttcatc atatggagac atcggttttc cttgggtgtt gacaatgatc 2793301 tcctcaggat catccaatct cgtataattg acgagaccct ctgccattcc gaacacctgc 2793361 tgcagcgtgc agccgaaaac agcttttacc ctgcgcgcgg cttcagcact aaacttggca 2793421 ccgccgacct gcagcacttg aaggctggat aaatcatcac ggcgtgagga tgccgcatcc 2793481 atccatacca tcgcaagagg cggaacaaga gcggttatcg tgaccttttc ccgttcaatt 2793541 aaaggaaatg cgtcatctgg acttggagaa ggagataata ccactcttcc tccagcgtat 2793601 aatacgccga gaacgccggg tgagctcagc ggataattgt gtgccatcgg cagcgcggcc 2793661 aagtacaccg tgctgtggtc gagccagcag acctccacac tccgcttcag gctgtatatg 2793721 tagtcatcgt gggtcctcgg aatcagtttc gatagcccgg tgctcccgcc agaaagctgg 2793781 aggaacgcca catccgatga tttgacttca ggcagtttta caggttctgc atgcaaatcc 2793841 tccagcggta aaaattcctc tgcctcacct gcgacaatga tgtttttcaa agtcggcagc 2793901 ttgctttgaa cctgtctggc aagcgaacgg tagtcaaaac cggaataagc gtcgggaatg 2793961 atatatgcag ccgcttcagc aaactcgcaa aaatatgtaa tttcactgct tcgatgagaa 2794021 ggcagtgcga agactggaag cgcccccaga cggaaaagcg cgaaaatgac ttcaaaaaac 2794081 tctttgatat ttggcaactg caccacaaca cgatccatct gttgaatgcc gagcttttga 2794141 aatccggcag ccaggcgatc agcccttgtg tcaagctctc gatagctcca atgggtgttt 2794201 ccgcatgtaa tggcaatgcg atcaccatat ttggctgccc ggtcccttaa caaatctcca 2794261 aacgtctcac cggcccagca gccgttcttt cgataggtct cagctaactc atcaggccaa 2794321 ggcgtaaatc ctttcagcat gttgtatccc tccagcaatt cattctgttc atatgtgatc 2794381 cacgcccatt gcccgcagca ttgtccgaaa ctttgcggac gtctcctgaa gctcgtcctc 2794441 aggctttgaa ccggccacaa caccagctcc agcatacagg cggagtgagc gttcttctgc 2794501 ttctgcacaa cggatggtca cgatccattc tccgtcaccg gcatcgtcac accatccgac 2794561 catgccggta aagaaaccgc ggtcaaatgg ttcaatgctg agaatcgctt ctcttgcaag 2794621 atcagtcggt gttccgcaga cggctggcgt cgggtggagc gccgccgcca attcaagtgc 2794681 ggttacagac gggtcggaaa gctctccctt aatcacgctg gacaggtgcc acatcgtttc 2794741 cgttttgatc agtgaaggct tctccggaac ctccagcgtc cggcagaaag gtctcagcgc 2794801 tgccgcaacc gcgtcagcga caaccgcgtg ctcatgaaga tcctttgcgg aagaaagcaa 2794861 ttcagctgcc cggcgctggt cttcaacagg atcattactg cgcggtcttg agccggctaa 2794921 tgggttggaa acgacctgtg ttcccatcct tgaaacgaga agctccggac ttgctccgag 2794981 caatgttctg cggggagacg tttcctcctg actggacacg tctgcggcaa acgtgtagcc 2795041 atgcgagtta tgctgagcca gatggcgaag caattcatcc gtctgaatcg gttcaggcga 2795101 tgtcaaatgc agcgatctgg acaggacgat tttgctgagt gttccatcgg caatgcgtgc 2795161 cagcccttgt tcaacaccat ttttataatc ctcaggttca ggaacaggct ttatgtggta 2795221 tgtatgccca gcctgctgtt ccttttcctc atgatcaaat tgaagcggtc ctgaccagcg 2795281 cacttcttca ggtacaacga gccgcgctgc ttttacttga tcaaaaggaa cggccccgac 2795341 aacaagcggc cggctttgcc ctgattgttt tgcctgacgt aacgcctctg caattcggcc 2795401 agaaagggtt tccatttggt tttgcccgtc tgcctccggt acaatttcac atatgccttt 2795461 cgctaacagt acacgatgag gagacgctaa gaaaaaggcg cccggctgat attcatgaag 2795521 caaatgctcc gcttttgttt ctgttataac gttttgatcc aacattctca tgaacctcct 2795581 ttaaattcag ttacacgcct aaggtcgcgc cgccatctac gcataaatta tgcatcgtaa 2795641 tatgccctgc ctggccagaa accaaaaaga gcaccgcatc cgcaatatcc gaaggcttgg 2795701 ctagtttttt gagcgggatc cctgttttaa atgtctcaag tgatcctttt atgacttgct 2795761 ccgctccatt ctcgtcggcc cataatgacc actgcatgtc tgtttccgtt gatccgggag 2795821 atacaatgtt gcagcgaata ttgtattctg caagctcaag gccaaggcat ttcgtaaaca 2795881 tcacagccgc agcctttgaa gacgcatatg ccgccataga tgttcttggt acaccggcag 2795941 cattcgatcc gactgttaca atcgaacccg atcttcggtc catcatatat ttgctgactg 2796001 aacgcgaggc gttaaatacg ccagtcgaat tcactgagaa cgtcgcctcc cattcctcat 2796061 cgctaagcga atggatcagt cccgggcgaa ggacacccgc tacattcact aaaatatcaa 2796121 tcggccccat ttcacgttcg atgcgcgccg tgatctcgtc aatcgccgcg ctgtctctca 2796181 catccgcagg aaaagcttct gcatggcggc cttctgcttt gaggctgctc acaacctttt 2796241 ccagcttttc aggattataa tcaactgccg caatatgtgc gccttgactg gcaagcgtcc 2796301 gcgcaacagc ttcgcctatt ccttgggcag cccctgttat aaaagcaatt tttccctcta 2796361 taccctttgc attcatatca tcaattcctt tcttcgctct aaatgccaaa cagacatcca 2796421 gcgaaaaaga ctgctgcgcc ttgaaaaacg caatctattg ataatgatta tcattatcaa 2796481 ttataaaaat aatcatatcc aaatgtcatg tgacagtcaa atataatttc agtgacaaat 2796541 atttttttaa aggcaaggct gagtatgtct cagcccattg atagatgcgg tccgtcaggg 2796601 tgaagcgcaa aacgcagcgc cctgctgacc aaaacaggaa gaactgaaat atgtccttct 2796661 cctgaaaact cgcaaaattc tgcccgtata ccttgttcag ataaaacggc cagccgctca 2796721 taaagctccc ttgcattatc attcatccgg cttttatgat gctgctctaa ttctcctgcg 2796781 gcaagcagga tattgatagg ctgattgttt ttcttggtga gagagacgaa atggtccgtt 2796841 ttcttgagaa taaacggttt attccaatga atggacggac ttcccgcgat atacgtttga 2796901 aacgcatcgg gctttgttag cagcacctgc agcacgaaaa gccctccgag cgaatggcca 2796961 aagattgttt gtcttttttt atcaatctgg taatctcgtt ctatctccgg ttttaaatcc 2797021 tcttcaataa atctgaaaaa gccctccgct ccgccatgct ccggccattc tctgccgtcg 2797081 ggcctttccg gcagcttcga ttgggctgtt ggcattgtaa aatcccggtg gcgtgctgag 2797141 gagaacggct ccgctgtctc atagccaatg ccgacgatca ctgcagggat caccccggtt 2797201 ttttcgggtc ggcgtccctg tattcgaacg gcttccgtca tcgttccgaa gacagaattg 2797261 gcatccagca gataaatcac aggataacca gcgggtggcg gcggcgtact aggtttcgag 2797321 ataaaaatgt gataggtacg gttttcattg cgtgaagaca tcatacgcac ttccgtacca 2797381 ggaatcgtaa atgcgtttga tgtcccgcca tttgtccggt ctgttgtttg ttctttcatg 2797441 cagtacgaca ttcctctcct taaactaaac cgcaatgtat gataatgatt ttcactatca 2797501 actagacacc tcaaataata ggttttcttc caaagaaagt caactttttc ccgaataaaa 2797561 aaggcacctt gatcaaataa ggtacctgca gactatcaat atggaagtaa aaacctaata 2797621 aagatgcgta ttgtcctatt tgaaatagaa ccttaatccc atgtaaacct ttgattttgc 2797681 caagggtcgc ctctcatgtg atagccattc cgctcccaaa agccagggtg attttctttc 2797741 gtaaattgga tgccgcgcag ccacttggcg cttttccaaa aatacagatg cggaaataca 2797801 ccccgcagcg gaaagccgtg ttcaggggtt aaaggttcgc cattatgcgc ataagccaga 2797861 agggaagttt ccgctaagaa atcatcaagc ggcagattgg tcgtccagcc ctcttcagca 2797921 tgtaaaatga cgtagcccgc ttcttctttt acacccgctt tttccgctat atcacaagcc 2797981 cgcacgcctt gccacacatt atcaagcctt gaccatcccg tgacgcaatg aatgtcgttt 2798041 ttcgattcat accgtggaaa ggctttgaca tcttcaaagc ttagcagcat cggatggtca 2798101 accaaaccgt atacttgaag attccatttc gtcatatctt cgtaatatgg gacatctccg 2798161 gtatgaagca caggaaatga agtggtgacg ttttgatttg gcggcactct tccagattga 2798221 tcggactgtc ttgtttttcc gaaatacata tgggcctcct ttttgttaac ctaatttaaa 2798281 atcatgttga caatcttttt gttctttatt actctatgat tgtgtatgtc aacctaaggg 2798341 ggaacaacga tgaaacaacg taaacttcgt gcgggagata tggcgctgat tggcatgttc 2798401 gccgcactta tggctgtcgg ggccaacatt acatcagtag cacccttttt acaagtagcc 2798461 ggcattccgc tttcgatgca gccgtttttc tgtctcttgg cagctttgct tcttggcagc 2798521 aaacgggcag cgattgccat gattgtatat gcacttgtgg gattggccgg agcgcctgtg 2798581 tttgctcaat tttcagcagg cttcgcaccg tttgcaggga aaagcggcgg gtttattatc 2798641 tcatacattc cggcagcatt tgcagcggga tggtttttag aacgaaacat tcagccaagt 2798701 aaaattcgat ttctcattgc ttcacttatc ggaacggcga tcatgtatct catcggcact 2798761 acctatatgt atcttgcact gaagctgtgg attcatacgc cagtgagcta cggcacggct 2798821 tggggcttta tgatttggtt tatggtaaaa gatacagcgc tggctgtgat actgtcgttt 2798881 atcgcaccag caatctaccg ctctattcat aaagcaaccg gctttaacag aaatcacata 2798941 tcatctacgt aaaaaccgtt ctattggacg gtttttttat cataacgaga aaaggctccc 2799001 cagtaaaggg gagccttttt cctataaaac aagcgctgca atccagccaa agatgacaag 2799061 cggaatatta taaaatataa atgtcggcac acaagtatcc caaatgtggt gatgctggcc 2799121 gtccgcactc aaacctgaag tcggcccaag cgtactgtca ctggcaggtg aaccggcatc 2799181 gccaagcgca gcagcagccc cgataatcgc aatcgttgcc atcgggctga atccaagctg 2799241 catgcataga ggcacgaaaa tggttgtgat aacaggaatg gtcgcaaaag aagatccgat 2799301 ccccattgta attaataagc cgacaatgag catcagcaat gcgcccaagg actgactgtg 2799361 tccgataaaa ccagctgacg ttttgaccag tgactcgaca tctccggttt tcgtcaatac 2799421 gtttgaaaat ccggctgcaa caagcatgac aaagccgata aaggccatta aaaccattcc 2799481 atcagtaatc agtgagtccg cttcatcacg cttcatcaca ccgctgacaa acagaacaat 2799541 cagaccagcg agcgccccca taatcattcc ttctactccc aaagtctgag ataagtaaag 2799601 ctggacgccg agtgacacaa caatggctag aaccgcgata ccaatacttt ttctcgtata 2799661 tggcgatgct tctgcacctg aaatgtcttt tgtttcatat tgtttcggtt tacggtatac 2799721 gatcactgat aaaataaggc cgacaaccat acctgcaact ggaataatca gtgcgtacgg 2799781 aatatcagca agcggaacgt ttaacccggc atccgccata ttgtccttca gcatgccttg 2799841 gaagatttgg ccgaaaccga ccggaagcaa aatataagga gccgttaagc caaatgtaat 2799901 tacacacgcg atcagacggc ggtccatttc aagttcatta aagattttca aaagcggcgg 2799961 aatcagcacc gggataaacg cgatgtgaac cggaacgacg ttttgcgaaa aacaagatac 2800021 aattaaaata atcagcacaa tcagcacctt agacagtgct ttttttcgag aatcttcttt 2800081 atttccgatt aatttaacgg aggcttccac cattgcgtcc ggaagacccg ttttcgtcaa 2800141 agcggcggca aacgcgccaa gcatggcata gctaactgca acggtggcat ttccgccgag 2800201 accgtctgtg aaagctttaa ccgtttcgcc aagaccgagc ccgcctgtta acccgccggc 2800261 caaggcgcct ataattaatg cgataacaat attgacacgc agcaggctta atacaagcat 2800321 aagcaggact gcgatgacga ctgcattcat gatgataccc ctccaaaaat cctttagttt 2800381 gctaatgtag tagataaata aagtacgaac gtatcgtatc ataaccgatc cactttagtc 2800441 aactaaagat ttcggaagaa aaaatccctg ccgcatcata cagcagggat ttttcattac 2800501 tcgtttttat cttcttccaa tgtaaatcgc tccgcaagtg tagccagtgt tcttgccata 2800561 acgccagtag ccccggccgg tccgaagcag gttgctttat tggcagtcgc tgtgcctgca 2800621 atatcaaggt gaacccaagg tgttgactca gcgaattcac caagaaacgt tcctgccata 2800681 atcgcatgtc cctcgcgtcc cggtgaattg ctgagatccg ccatttggct gcttttcacg 2800741 cgttttttat ccttctctgt tatcggcagc tgccagatcg cctcgccgca ctcttgtgca 2800801 gcatcagcta cctgctggta aaagctttga tcatttgtca ttgcaccggt tgtttctgtt 2800861 cctaatgcca caacgacgcc gccggtaagc gtagctacat cgacaagaac tgatgcgcca 2800921 tgctgtttcg cgtatgtaat gccatctgca agcactagcc ttccttcagc atccgtatta 2800981 aggatttcta ttgtttttcc gcttaaagat acgatcacgt catccggctt catggccccg 2801041 ccggagatca tattatcggt tgatggaata acgcacagca cgttttgttc aggacgaagc 2801101 tctccgatcg tttccatagc cccgagaacc gcagctgctc ctcccatatc tgatttcatg 2801161 ccaacaattc cagatttcgt tttaatggag tagccgcctg tgtcaaaggt aattcctttc 2801221 ccgactagtc cgacgacgtc ttcccattcc tttttgccct gatatttcaa cacaatcatt 2801281 ttcggcggtt cggtggagcc ttggtttacc gcaagtattc cgcccatacc gagctcttcc 2801341 atctctgatt tctccaatat ctcacactca aaatcatatt tcgccgcaag ctcttcagca 2801401 tacgaagcga ggtcagtcgc tgtcagcatg tttcccggca tattcacaag cgttctagcc 2801461 gaatttgtcc cttgtccgta tgcctggccg acgcgaagcc ctgcctgcac ttcctgtgta 2801521 tcttcatctg ttacaacata cacggcttca atttgtttgt caggctcatt tgatttatgc 2801581 ttataatcct gcacctcata ggaagcaagc aggcagctct cagctaaagc atgagcggca 2801641 tcggctggag gcacgtcttc cgaaataaac gtatcaagca gaacagcagt ttcttgtttt 2801701 cgatctttat gaatggcttg aaaaacatga gcaaaacgtt ccttcgcctg ttcaaacgaa 2801761 taatttgctt ctctccccag gccaacgaaa taaatccgtt tcatacccgc agaagatgga 2801821 gggaatactt ttgatacttg attcggtttc gcagagacat caccctcttt taaaagctgt 2801881 gtcagatggc cttcgagcat ttcatcaatt tccaacgctt ttcctgtcag ctggcttttt 2801941 tgaaaaagcc cgacaacaag ggtttctgta tgctctgatt gttgaaccgc ataaaacatg 2802001 aggcttacac tcctaacgta atgggtattt gtaatgaaca atggtataat aggaaaaaca 2802061 ttctttccac tatacttatt ttaacaaaca acagtctaag acttgctttt ttcttttgaa 2802121 acacgaagga tttttcaaat agaaaggatg tcgccgatgg aacttttaac gaattttcct 2802181 ttattatcaa gcctggccgc aattattttt gctcaggtca tcaaagtgcc catacagttt 2802241 atcgtgtcca gaaaactgga ctggtcgctg gtcacaagca caggcggcat gcctagctct 2802301 cactccgcag cggtcactgc gctttctaca ggcgtagcct tggagcatgg attagactcc 2802361 tcactctttg cggtttccgc cattttcgcc gtcataacca tgtttgacgc aactggcgtc 2802421 agacgtcacg ccggtgagca ggcaacagtc attaataagc ttgttattga ttttaaccgt 2802481 ttcgtaaatg aagcgaagga cttccctaag gctgcagaga aagaaaagca aaaaaagctg 2802541 aaagagcttc tcggacatca gccgatcgaa gtctttttcg gaggattaac aggtatttta 2802601 ctgacattgg tactcgctta ctttttcatg taaaaaaaac gctcctgctt tcgctggagc 2802661 gttttattct ttcaccgttt tatattgatt tctgaacact tgcaaagatt ttgtttcatt 2802721 gagcttctca agctcatcct cggtaatctt tcccgttccc tttttaatca catatacatc 2802781 aagggttttt ttgccccatt cattgtatac atctttgact gtctcaaagt acagatcaag 2802841 gcggtttccc ttaatagctg atcctgtgtc ggccacaact ccgagaccgt agttcggaat 2802901 gaataaaatt gttccgatcg ggaaaacgga cgggtcagca gcaaccgtgg aatataaatc 2802961 ccgtttcact ttcacacctg aatatgtaag cccgtataat ggatcaccgg gatttttgcc 2803021 cgtcgactca gctcctgctg tgtagcctgt tgctgttact ctttggactg gatattcatc 2803081 ccaatcaaat gcctcttcta acggttttgt tttatcctca gccgcggacg tggtttgtgt 2803141 ttgtttctgc tgcaatgctt ttaatctcag tcctgcatgc ttcaagtgct tttcctgatg 2803201 ttcctgcacc cattttgaca agtccttcgc ttcaattcct gacactgata aaaatgtcgt 2803261 gccaaatgca agcagaaata aacaggtcat cagcaaacgt ctgatcatat tcaacatcat 2803321 tcacctctcc tccgaatcat tgttcccaag tggagagagc attattcaaa atggtgaatg 2803381 agctgaacgc ataaaaaaag ctttctttag aagaaagcgg catttaaaac atttgatatc 2803441 ctctttttct aagcatgttg atcgctatac cggacacgat ggcgccggcc aaaccgctga 2803501 ctaaaatcag cacatcagca gccgctaatg ataagacacg atgaaacagg ctggcaaagg 2803561 attctcccgg cgactggaca tagctgatca gcttttcttt gctgataatg aaaaggcata 2803621 caattggata aatcacagcc ataatccaag acattctcag cagcatgttt aataagaaac 2803681 cgattccaaa aaacaagaca aaaaacaaaa caattgagat gattacgact ggcagactaa 2803741 tcaacctatt ccacccccct gcgttgtttt tagtgtaacg cgggggctga aataaagtca 2803801 acggctggaa aaagaatgac tgtcttttcc tgtcccctgg caagacggac aagtctctga 2803861 accgccgaga atcaattgaa aatatccttt ccctgaacaa aatgggcatg catgtgaagc 2803921 ggttgtcgtt gcagttttca tctaatcatc accctttttc ttaattttct gataatatac 2803981 catatcaagc tgtcaacaat aaagtcagat catgtgacaa atcttttgat gtaagcggaa 2804041 acatacttgt tttcctctcg ttctcttttt attttggcgt tttttaataa agaaaacccg 2804101 cttccgcggg tttttagaaa aacttgaact tgcctttttt caatgtcagt ccgagtccgc 2804161 caatcataaa cagtgagcgg ttatcaatga cttttttcat aaacgaagcg ggcgtgcctt 2804221 tcagctttct gccataaaca accccaaccg cgttatgctc gccaagagaa gccactgttc 2804281 ccttaatgtc cggcttgaat tcctcaagct ctccgccttt aataagcctg ccaaggtttt 2804341 tagcgaccgt tatgccctgc tgcattgcaa tttgcgcagt cggcggatac gggcgctctg 2804401 tatcttcatt cataaacagc gagctgtcgc cgagaataaa gacattgtca tgtcccgggg 2804461 cgcggagatc agggttgact ttgactcggc cgcgcatatt ctcaaaaccg gcttcctcca 2804521 caatcggatg gccgcggaca cctgccgccc atacaacggt ttgcgatttg atctgctctg 2804581 gttcttcatc ttttttgccg actctgactc cttctggtgt acattcttgt acagccgttc 2804641 cgatcttgaa ctcaactccg ttttcctcaa gataatgtac ggcgtaatca acaagttccg 2804701 gatcaaagcc cggcaaaacg gtcggcgctg cttccacaca aatgatgcgg acaaggcttc 2804761 tgtcaacgtc atattcctta cagagctccg gcacgcgagc agccagttcg ccaagaaatt 2804821 caattcccgt aaatccggca ccgccaacaa cgatcgttaa cctgtccggc cgtttttccg 2804881 cttccgtatt gtaagtcgca aactgcagct caatatgttc ccgcagcagg cgcgacgtgt 2804941 tgatgttggc aatcggaaac gcatattctt ttaagccttt aatgccgaac gtttcaggca 2805001 cggcgccgag cccgatgact aaataatcgt actgcaattc tccattcgca agcacaactt 2805061 ttttctcatc aattttgatt gcctttacgg tatcctgtac aaaattcacc cgtgactggt 2805121 tgattacatc ttttatctga taacggcagc ggtcatgatg gagcgtaccc gcgctcgctt 2805181 catgcatcca tgtcgtttca taatgataat tgtgtttatt tacaagcgta atgtcagcat 2805241 cattcggccc gacatacttc gtcagccttg tcaccgtcat caatccgcca tatcctgcac 2805301 ctaaaatcac gattttgggc ttattcaatg ccatcacatc caccttctct ttttttgctt 2805361 ttgttagacc cataataaaa tcatcatttg tgttagcttc agcttattgg cgggatttta 2805421 tgaaatatat tgaaaagttt tttgtgaagt ccttacccgt agcactatta tcatgtttat 2805481 ccggctggcc caagaaacat tcagaaaaag atcatttcat ttggttatta tcgtagcggc 2805541 ctgcggaaat attttcaaga acggatgggc acgttagatc cttacgattt tttctgctga 2805601 ctcgtcaatt tgaacggcaa tatggtataa ttaataacaa ttttcattta ggaggcaatt 2805661 ttcgtatgcg agaggataca aaggtttatg atattacaat tataggcggg ggaccggtcg 2805721 gcttattcac cgctttttac ggcgggatga gacaggcaag cgtcaaaatt atcgaaagcc 2805781 tgcctcagct cggcggacag cttagcgccc tataccctga gaagtatata tatgatgtag 2805841 cgggattccc gaaaatccgc gcgcaagagc ttatcaataa cctaaaagag caaatggcga 2805901 aattcgacca aaccatttgt ctggagcaag cggttgaatc tgttgagaaa caagcggacg 2805961 gcgtgtttaa gcttgtaaca aatgaagaaa cccactactc taaaacggtc atcataactg 2806021 caggaaacgg cgcattcaaa ccgagaaagc tggaacttga aaatgccgag cagtatgaag 2806081 gcaaaaacct ccattacttc gttgatgatc tgcaaaaatt cgccggcaga cgcgttgcga 2806141 tccttggcgg tggagattcc gcggttgact gggcgcttat gcttgagcca atcgcaaaag 2806201 aagtatcgat cattcaccgc cgcgacaagt tccgagcgca cgagcacagt gtggaaaacc 2806261 ttcatgcgtc gaaggttaat gtcctgacac cattcgtccc tgcggagctg atcggcgaag 2806321 acaaaatcga acagctagtg cttgaagaag tgaaaggcga ccgcaaagag attttagaaa 2806381 ttgatgactt aatcgtcaac tacggtttcg tttcatctct tggaccgatc aaaaactggg 2806441 gcctggacat cgagaaaaat tccattgtcg tgaaatcaac aatggaaaca aatatcgaag 2806501 gcttctttgc agcaggtgac atttgtacat acgaaggaaa agtcaacctg attgccagcg 2806561 gcttcggcga ggcaccgaca gcagtgaaca acgccaaggc ttacatggac ccgaaagccc 2806621 gcgtacagcc tcttcactca acaagtcttt ttgaaaataa ataataaaaa aaggagcttg 2806681 tgtctgcgac acagctcctt ttttatttga agatatttat ataattcaat gcagttccta 2806741 caaccagcgc aatcacaagg gctgcgacta cccagatcat tgccataata atgcggtcct 2806801 gaatcttttg ggacttcggt gttttttctt cgttttgggc catcttattc gctcctttcc 2806861 catgtccatg ccataaagaa agcctggtgc tgaacgacca agctttgctg aacgtatatc 2806921 attcgcgttt tgatccgctc tctaagacca ttcgttaaaa ctatgatacc taaactcacc 2806981 ctgcatgaca agcttcggca cttgcaccac acctgccagc aaatcataat gtttgacatc 2807041 ctaaataaaa cagagtacat tatataaggc gaacatttca tatattatac ttttaaatat 2807101 tcgtttttag gagtgaaaac catggaaaac gtatttgatt acgaagatat tcagctaatt 2807161 cctgcaaaat gcattgtgaa tagccgttca gaatgtgata catccgtacg tttaggcgga 2807221 catacattta aattgcccgt cgtccctgcc aatatgcaga cgattataga tgaaaaacta 2807281 gcgatttcat tagccgaaaa tggctacttt tatgtgatgc accgatttga gcctgagaca 2807341 cgaattgatt ttattaaaga tatgaacgca cgcgggttat tctcttctat cagcgtgggc 2807401 gtcaaagatg aggagtatga atttgtccgc cagctggcag aagaaaatct gactcctgaa 2807461 tacgtgacaa ttgacattgc tcacgggcac tcaaatgctg tcattgaaat gatccagcac 2807521 cttaaaaaac atttgccgga cagctttgtt attgctggca atgtcggaac gccggaagcg 2807581 gtcagagagc ttgaaaatgc gggagcggat gccactaaag tcggcatcgg accgggaaaa 2807641 gtatgtatta cgaaaatcaa aacaggcttc ggcacaggcg gctggcaatt agcagcgctg 2807701 cgctggtgtg ccaaggctgc cagcaaaccg attatcgcgg atggcggcat ccgcacccat 2807761 ggcgacatcg caaaatcaat ccgattcggc gcaacgatgg tcatgatcgg ttcactattt 2807821 gccggacacg aagaatcgcc aggccaaacg atcgaaaaag acggaaagct ttacaaggag 2807881 tacttcggct cagcctctga attccaaaaa ggcgaaaaga aaaatgtcga aggcaaaaaa 2807941 atgcacgtgg cgcataaagg ctcaatcaag gatacactga ttgaaatgga gcaggatctt 2808001 caatcttcta tttcttatgc aggcggaaca aagcttaacg ccatccgcaa tgtggattat 2808061 gtgattgtga agaattccat ttttaatggg gataaatatt aatcataaaa aaacgccaag 2808121 tcagcggttc tccgcttgag ttggcgtttt ctgctacttc ttcagcaaag taagcttata 2808181 tttgcttttt gagtttatct tccatcagtt ctgccatttg ttttgcattt ggattttctt 2808241 cattttgcaa ctgttcaatg acgttcatat aatccgtttc atttcggttc tggcttaatt 2808301 tatatgccgc ttgaatgtct tccaccttaa tcttaaatcc aacaatacct ttcaattcac 2808361 tttctaagag ttttggagaa agcttatccc ataacacagg attgtcacga tgtttttcgt 2808421 atttctccaa catgattgtt aattcttctg ctaattcatc tttctctaac atacttgctt 2808481 ttccatacat gtggacagcc tgataattcc acgtcggaac attttcgcgc gaataccagg 2808541 aagaagaaat ataagcgtgc ggtccctgaa acatcacaag cacatcttca caggcttcaa 2808601 acgttctcca ctgaggattt ccataagcga aatgccccgt aatatagtaa tgatcgtctt 2808661 ttttattgaa tcctaacggc aaatgtgtgg caattggttt tccttgttct gttgtgacaa 2808721 ccgtaccaaa ggagttttct tgtacaaaat tccaaatttc ttcagcattt gtgactttaa 2808781 aatattttgg aatatacatc atcatccacc cttcgaaaaa tattatatga gtgttttagc 2808841 catgattaaa tccgtttgtt cttcatcacc catataaaat gagtgggcgc cggtctgaac 2808901 aaaccccatt ttcttataaa aggcaatggc attttcattt ttttcccaca cacctagcca 2808961 aatgttcttt ttattacgtt ccagcgcaat ttctatcgct ttattcagca gatgtttgcc 2809021 aagcccatgt ttttgaaagc tgttctttat ataaattctc tcgatttcaa gtgattcagc 2809081 acccatttct tcagactgag catcatcgat attgaccttt acatatccag cgatttcatg 2809141 atcaaagtaa ataaaaaaga attgcgaaga catattagat aactcttttt ccagctgctc 2809201 agtgttaaat gcgctttcta aataggcttt catattttca ggtgagttct gttctttaaa 2809261 agtgtcattg aatgtttcaa tactcaattg ttgaagtgtt tgtaaatctt cccggctgca 2809321 ttttttcatt tttacactca ttgttcggat tcagcccctt tatttaaaat tcaattgtct 2809381 tgtgtccctt ttatatattt aaacacggaa cacatactga ccttgttacc attccaaaaa 2809441 tcttcttcat caccaactcc ctatcgtgat tttgttgtaa atgcaataaa atatactccg 2809501 cattaaatat atcgtaactt tgctgtattt acaacaaaaa tcaaacaaca aagcagcgtt 2809561 tctcttgccg aagttcccgg aactctctgc atcatttccc cataataaaa acgcctccct 2809621 taacgatgat ttatcgctaa gaaaagcgtc agtaatagtt gctatccgtt tttagtgctt 2809681 agcactcttc aggcttgcct gcattcgttg ctgttctgaa cgaagaaccg cagccgcatg 2809741 aagcgatggc gtttggattg tcgatggtga agccgccgcc gagcatggat tgtttataat 2809801 caatcacggt gccgttcatg atgtcaaggc tttctttgtc aactagaaca gtgatgccgt 2809861 gctgatcaaa cacactgtct gattcactct tttcatgctc aaagcccatg ccgtaagaaa 2809921 gtccgctgca gccgccgcct ttgacgccta cacgcagaaa cgcgttttct tcttcatgct 2809981 ctttcatcat atcttttata tgcaaagctg ctgcttctgt aattgttacc gggttgctca 2810041 tcattatgaa cctcctttta aaaaccggtt gctgtctttt attataaaca tgatcgttcc 2810101 aattctcaaa caaggtgttt tacaagaaat agacaccctc acaaacggtt tcagccggcc 2810161 ctgtcatcat tacatggccg ttatctttcc agtttatcac caaatccccg cctgctaaat 2810221 gcaccgtgat gtcttgattt cgctttgata cgccgtttaa tacagatgcg actgccgctg 2810281 cacatgctcc tgtcccgcat gcctgagtaa tccctgatcc ccgttcccag acgcggaaat 2810341 gcaattcttg ttcattcacg gtttcaacga attccacatt gatgccttcc ggaaatctcg 2810401 gatctttctc aatcaccggc cccagtgtcg ttaagggtgc ctgttcaatg tctgcgatcg 2810461 gaaaaacgat atgcggattt cccattgaaa cggcagtgcc tgttagttct acttcaccaa 2810521 atgccatcgt ttcattgatt gtgtgctctt ccccgccgtc aagcatagga agctcggatt 2810581 ttgtcaagcg cggttcgccc atatcgacag tgaccacatt cacttttccg ttttcgactt 2810641 gaacctccgc tttcacaagc ccggagagag tttcaatcag aaaagatgtt tcctcaacca 2810701 gcttatgctc atatgcgtat tttgcgacgc agcgcaggcc gttgccgcag tttttccctt 2810761 cagacccgtc attattaaaa atccgcattt taacaggcgc ttggtctgat gggcatatca 2810821 ggatcattcc gtcggatccg atccctgtat aaacagaaga aacctgaatt gcaatctctg 2810881 acagtttttc ttctggaagc tgttcttcaa attgattcac ataaatataa ctgtttccca 2810941 ggccgtgcat tttggtaaat cgaaatgagt tcataggtgc ctccaacttt ttttcttttt 2811001 cttagtataa aagctattat aagcggacac aatacaatta tcccccgttt ttcatacata 2811061 aaagctcctt gcactgacgc aaggagcttt tatcgtttat ataaacatgc cggcaatggc 2811121 tgcgctgagc agattggcta atgttcctgc aagaacagcc ttcaggccga gacgtgcgat 2811181 atctgaacgg cggctgggcg ctaaaccgcc aagcgtacca agcataatcg caattgatga 2811241 aaaattggcg aatccgcata acgcgaaact gataatggta gcagttttct tagaaaactc 2811301 gccgatgtgc gaaccgaagt tagaataagc gacaaactca ttcagcacca atttctggcc 2811361 gatatagctt cccgcctgca atgcttcatg ccaaggcacg ccaatcaaaa aggcgatagg 2811421 agaaaacaca tagccgagaa tggattctaa tgttacgcct tttaaaccga acaagccgaa 2811481 agccccgccg agaataccgt ttactacagc gattaacgca acaaacgcaa gcagcatcgc 2811541 cccaacattt aacgcaattt gcagtcctgt tgacgctccc tttgcagctg cgtcaatgac 2811601 attggctgcg ccttcgcctt catccatttt gaaatcgctt tttacggttt gcgttttttc 2811661 cgtttcgggt ataatcaatt taccaaagac tagtccagct ggagcagcca taaagctggc 2811721 cgccagcaag tactcaatcg gaataccgag aagcgcgtac ccaaacaagg tagatcccgc 2811781 aactgccgat agaccgctcg tcataatcgt aaacaactca gagcgcgtca gcccggcaat 2811841 caggggtttg atcactaacg gagattctga ttgtcctaca aaaatattgg cagcagccgc 2811901 cagagattcc gttttgcttg ttccaaggag cttcgacaat ccgccgccaa tgacacggaa 2811961 aacgagctgc atgattttca aatgatataa aactgcaatc agtgctgaga agaaaatgat 2812021 aacgggcagt acacttaatg caaatgccgg actgtctccg acctttagaa gcggtccaaa 2812081 aataaaactg atgccttcat tcgcatagtc aatcagaagc tgtacacggc ttgaaaacca 2812141 taaaaaaaca gcgcgtcccg cttcccattt caacacgatg tatccaaacg ccacctgtgt 2812201 gcataaacca acgatgacgg ttcttatctt aatattgctt ttcttttctg aaaataaaaa 2812261 cgcgatagca atgatcgcaa ctgcgcccag cagcccccac agaacattca tgaatactcg 2812321 tacacctctt aaattttatt taaaaaaata tcttttatac gataacaata atattttttg 2812381 atgtctacac atttttttag ttcttttgta cggcaaaata aaaaagggcc tgtccaggcc 2812441 cttttcttta aaacattgga ttttcttcaa taaaggtata tatattctca acaagctcag 2812501 caggcgtttc acccatgacg acttctccgt ttaccagagc gaaaagcgat tccatacatg 2812561 tcccgcagta gcttaagcag ccatattcaa ggacatcaag gttgggatcc ttctccaaaa 2812621 tcgcccgggc ttcctgagag ccgtgagcca gattgctgac acaaaattca atcattggat 2812681 tcatgcggtt tcacctcaca tatgtccatt atcgcgaatt tttcactatt cgtcaaagac 2812741 aacggatgat tcaaaattta ttatcgtaac atattatttc tcaaataacg ttttactaat 2812801 ttgtgttttc aggctaaatt gtaggttatt ttgaaactat tattgtgatt ttagatcaaa 2812861 ttcgatataa ttctagatgt tattttacat agttcgtatt ttcttcaatg tatctatcat 2812921 actcttcgga ttaaagggga attcaaatga aaaaattggt cttgatcggc ggaggttacg 2812981 ggaacatgcg cgttcttcat cgcttattgc caaaccagct gcctgatgat gtttcaatca 2813041 cgttaattga cagaaatcct tatcactgct tgaaaacaga atattatgcc cttgccgcag 2813101 gcacaatttc tgaccatcat atcagagtgt cattcccaga gcaccctcgc ctggatgtcc 2813161 aatacggtga tatcacatca attgatattg tacaaaaaca agtgctgttc caagatcgtg 2813221 aaccgatttc ttacgatgac gccataatcg ggctcggctg tgaggataaa tatcacaacg 2813281 tgccgggagc gcctgaattc acctacagta ttcaaaccat cgatcagtcc cgcgaaacct 2813341 accaaaagct gaataatctg agcgctaatg ccaccgtcgc cattgtcgga gcgggcttaa 2813401 gcggcgttga gcttgcaagt gaattgagag aaagccgtga tgacctgaac attattttgt 2813461 tcgaccgcgg taatctcatt ttatcaagct ttcccgagcg tttaagcaaa tatgtgcaaa 2813521 aatggttcga agagcacggt gtccgcatta ttaacagggc aaatatcaca aaagtagaag 2813581 aaggcgttgt gtataaccac gatgatccga tttctgcaga cgccatcgtg tggacagccg 2813641 gcatccagcc aaacaaagtc gtcagagact tagatgtgga gaaggacgca caagggcgta 2813701 ttgtattaac gcctcatcat aatcttccag gtgatgaaca tctgtacgtt gtcggcgatt 2813761 gcgccagtct tcctcatgca ccgagcgccc agctggcaga ggctcaagca gagcagattg 2813821 tccaaatctt gcaaaaacgc tggaatggag aagccctgcc tgaatcaatg ccgcagttta 2813881 agctgaaagg cgtcctcggt tcactcggaa aaaaagccgg cttcgggctt gttgctgacc 2813941 gtccgctgat cggccgtgtt ccgcgtatgc tgaaatccgg cttgctgtgg atgtataaac 2814001 accataacgg ttaatgatag agaagaaccg ctgatcaagt cagcggtttt ctgtataccc 2814061 atgcttctcc atttcctcat aaacgtcttt taattttgga ttgccttcac cgacaatttt 2814121 gtcttctaca agcacaagcg gataaaaata ctcgtcattt ctgatttttt ccgcaagctc 2814181 tttcgcatgt tcattgtcag gcggctcatg aatatcgatg tactgcatct caaaaggctg 2814241 atttggatat tttcttttca gcgcagcctc aagccactcg tatgtatcct tggctgtcgg 2814301 catatttaca cagctcgcac aaacgttttc tgccccgtac acgcttagca tgactggttt 2814361 catcacttgt agacgccccc ttctcctatg taagtccttt cttttaagta tacagagcct 2814421 aagggcgttt ttatagaaaa aaaccgtttt tgtgttgaag tctgaatgtg ctataatagg 2814481 gaaagcaact ttgcaaacca aacaatagat ttttattgtt acactgaata taatggtttt 2814541 atgacgacga aaggagcgaa tgtcatgact gaagttgaaa tgaaagaaca ggtgcaggaa 2814601 gtactggaca aacttcgtcc gtttttactt cgtgacggcg gtgactgtga gcttgtagac 2814661 gtagatgaag gtatcgttaa gcttcgtctt ctaggcgcat gcggcagctg cccaagttca 2814721 acaattacgt tgaaagccgg aattgagcgc gctcttcttg aagaagtgcc gggtgtcgtt 2814781 gaagtagaac aagtctttta ataaagcagc caggctgata tttgatcagc ctggcttttt 2814841 tattagagat gttgatcaaa ccatgagctg atataattca ggcgcttgat ccgctgtctt 2814901 gggtgtccgg tgcgtgataa attgtgcgat gcattcggaa aacggacaag cttggtttcc 2814961 ttgcccattt ttttcagagc gataaacagc tgctccgcct gctcgatcgg gcatcggtca 2815021 tcccgctcgc catgcagtat caaaagcggt gtctccacgt ttgctgcgta ttttaaagga 2815081 gaccggtccc agagcttttc tgtgtcctca aacatgtcat gctcaagctg ccagtctgta 2815141 aagaaatagc cgatatcact gacgccgtga aagctgatcc aatttgatat cgagcgctgg 2815201 gtaacggcag ctttaaagcg gttcgtctgc ccgacgatcc agttggtcat aaaacctccg 2815261 tagcttccgc ccgtgacacc gagccgctta ggatcaatat gcggatctcg tttgatagcc 2815321 tcatccacag cctgcatcac atcgtcataa tcctttcccc cataatctcc tctgaccgca 2815381 ttcacaaatt cctgcccgta gccgtggctt cctctcggat tgatataaac gaccgcgtat 2815441 cctttcgccg ccagcacctg aaactcatga aaatatgtat gtccgtacat catatgcgga 2815501 ccgccgtgta tgttaagaat aagtggatat gttgtctcac cttccatttg tgcaggcctc 2815561 atcagccagc cgttcaccat cacgccgtct tctgtagcat attgaatctc ttcaggtatt 2815621 gatatcgtat gctccctgac aaacttgtca ttcgcgccag tcagctgttt ctcttcctgt 2815681 ccaagcggga tactgtaaag ctcactcggt ctgtccggct ttgtcacact ggcaataaag 2815741 tgctgttcat caggtgaaag agaaaagcta ttgatgtact ctttttccag acgaatcgga 2815801 tacacaaggc cttcaatcga aatataatag atgcccgtac tgccttgatc tgtgccgatg 2815861 acataaaacc cttggctgtc ctttgtccaa atcgggcgct gttcagcacc accgatcaat 2815921 gaatctccaa tcagcgcatc cgctaaatga acgtccagca tctcagtaag acatgtgagg 2815981 cggccttgtt cgatatcata gagccacgcc tttgagagcg tagcattctt atattccttt 2816041 tcatttccaa gcaaagcaag ataccttccg tctggtgaaa atgagcttga tccgaatgag 2816101 ccgcgatgag gtgtaacctg cttaagatct ccagactcca gtgacattat gtaaacatca 2816161 tgcggcttgc tggcatcatc tgtttcagtt aaattagctg agaaaacaag ccatttgccg 2816221 tcaggagaaa aagcaggatc accatgatca gctttgtgac ttgtcagctc tttcatctca 2816281 cccgacttta cgctgacaag cacaagctgg gcatacgcac ctctcgtcag ccctttgccg 2816341 tcccgtttgt aggagaggcc ttgcacttca acaggttcat agctgtcctg ctctgttttt 2816401 tctcggtcat caatgctttc cccctctccc aaactgacag tgaccagaat cgattcaccg 2816461 tccggggacc atagcggctt tgacacgcca tatgggatat cagtcagttt tcttgcttct 2816521 ccgccttcag tgctcatgat ataaagctgt gccgcatcgc cttctcgatc agaaataaag 2816581 gcaagcgtgc gcccgtccgg agaccatctt gggtcggtgc ttcgcttttc tccatgtgtc 2816641 caaggaacag atcctcccgt tttcgtttca tagatccata tatttgatgt atacgaatct 2816701 ttctcttgat ttacttgtga ttttacatat gcggcacggg taccgtctgg ggcgtattga 2816761 ggatcggtca cagagacaat cgctgtgatg tcgtctgcgg ttatcagctt tttcatattc 2816821 atctcctcct ttttacatgt atttcgtttt tctaaataaa aactccttta tctccagcaa 2816881 aaaaaagcgc cctccgctga cgctgaggaa cgcttggcat gatctataca ctttttactt 2816941 gatataaagg atttcgctct attatacttc cctctttcgg aacggtcaaa gcgtctactt 2817001 cacaatgagg gaaatgaagc gcgagctgtt cttttagctc ttctcccttt cctttttcgg 2817061 tcatgacgag aatcgttggg cctgctccgc tgagagccgt tccatatgcg cccttcatct 2817121 cggcgacgtg ctctactttt gacagctcag gcacaagcat cgcccggtac ggctgatgga 2817181 acatatcctt cttcatgatt ttcccgacaa gcggccaatc cttggacatg atcgcagcaa 2817241 tgaggatatt gctgacagca cttgctttta cggcatcggc atatggaaac tccttcggaa 2817301 gcacgtctct cgcgtctctt gtcagcactt cataaaaagg aatgacaacg actacgtcaa 2817361 tgtcagcatt cgggacgcgg atcatttggg tctcgtcatc ctcatgcagg ccgatcacaa 2817421 gtccgccgac gagagaagcg ccagcattgt ccgggtgtcc ttcttctaga ctcgctaaat 2817481 gcagcttgtc cgcttcagac agctttaagc cgcataattc atcagccagt tcaatggccg 2817541 ctacaatcgc tgcggcgctg ctgccaaggc cgcgtgcaag cgggatgtcg ctccacacct 2817601 tcacatggac aggaggcatt tcttttccgt acaaatctgc ggtccgttta gccacttggt 2817661 agatcaggtt atctgtaccc gccggaattc cggcgactgt ttctgtttca gcctcaaaag 2817721 accatttgtc gctttcaaag acggtcagct tcaaatatct gctgagcgcc attccgactg 2817781 aatcaaagcc ggggcctagg ttagctgtgc ttccgggaac agtgacagag aacagcatgt 2817841 cggcttcgtt catacacggg ccgctccttt tacatattca aggatgctgt cttcatcagt 2817901 cggcaatgtg acaggcttga tttctgaaat gtcgaccgct gtgttcggat ctttcagtcc 2817961 gtttcctgtt aacacagcta cgaccttgct gcctttcgga atttctccgg atttcacctg 2818021 tttcagcact cctgcgatag acgcgcaaga acctggttct gcaaacacgc cttctacacg 2818081 ggcgatcagc tgatatgcgt gaaggatttc atcatcagtg acttcgtcaa ttttcccatt 2818141 ggattcctcg gctgccttta cagctttgtc ccagcttgcc gggtttccga tacgaatggc 2818201 tgtcgctatt gtttccggat tttcaatcac ttcattgcgc acgattgccg ccgcaccctc 2818261 agcttcaaag ccgcgcattt tcggaaggcc tgtgccgttt ttctcatgat attccttgaa 2818321 gcccttccag tacgcagtga tgtttccagc atttccgacc gggatcgcta aaacatcagg 2818381 cgcttccccc agctgttcgc acacttcgaa ggcagcagtt ttttggcctt caatgcggta 2818441 agggttgact gagttgacaa gggcaatcgg tgatttctca cagatggaac ggacaatttt 2818501 aagcgcatcg tcaaagtttc cgtcaattgc gataatctcg gctccgtaca tgacagcttg 2818561 agcgagtttt ccaaatgcaa tttttccgtt cgggatgatg acaatgcatt tcatgttagc 2818621 acgggctgca tatgctgccg cagcagcgga agtgttacct gttgacgcgc acataatcgt 2818681 gtcattgcct tcttcttttg cctttgccac agccataacc attccgcgat ctttaaatga 2818741 tcccgtagga ttgacgcctt ccgttttgac atgaagctca attccgagct gctcagacag 2818801 cttcggcagg tgaataagag gtgtgtttcc ttcatgtaaa gttagcgccg gtgtttgatc 2818861 tgttacaggt aaaaattctt tatattgatg gataagtcct ttccacatta gctccaaccg 2818921 ttcccttcta cacgatatgt gcttttgact tcttgaacga cttccaaatc atttaggttt 2818981 tgcaggatat cactgaaatc agcttctgat gtatgatgtg tgacaattac gatttcagct 2819041 aactcatcat ggcctttaat tggcagctga aggatttttt caaagctcac gccccgctct 2819101 gagaacacag atgtaatttt cgagaatgaa ccaacctcat cttttacatg aattcttaaa 2819161 aactgctgtg cataaatgtc agacggcgat ttcatgtttt tctcatattg cggtccgaca 2819221 aagctgttgc cggttacacc taggcgcata tttttcatga cagcgacgag gtcagaaaca 2819281 acggatgtcg ctgtcggcat gcttccggct cccggcccgt agaacatcgt ctcaccgaca 2819341 gcctcgccgt atacataaac agcgttaaac tcattatgaa cagcagaaag cggatgatgg 2819401 tcaggaagca gtgtcggctg tacgctgacc tcgattttgc tgccgtcacg ctgagcaatc 2819461 ccgatcagct tcattgtata gccgaggcgt ttgctgaagc tgatgtcctc gtctgtaatt 2819521 tgggagatcc cctttacttt gacgtcttcc agatccacgt tcatcgagaa gccgaggcgc 2819581 gccaatatcg ccattttccg tgcggcgtca agcccttcca cgtcagaagt cggatcagct 2819641 tcggcaaaac cgagatcctg cgcttccttg agcacttcct cgtatgggct tttctctttg 2819701 atcattttgg ttaagataaa gtttgttgtg ccgttcacaa ttcccatcat ttttgtaatt 2819761 cgatctgatg agaggccttc ctctaacgtg cgcagaatcg gaatcccgcc ggcaacactg 2819821 gcttcaaagt agatatcgca tccattttcc ttcgcttcgg caagcagctc ggagccgtac 2819881 acagccatta agtccttgtt tgctgtgaca acatgctttt tcgatctcag cgcgtcgacc 2819941 aaatattgtt ttgtctgttc aacgccgccg atcacctcga tgacgacatc aacatctgga 2820001 tcatcaatga catcatacac ttctgtcgtg agcacttcct tcggcaaatc tacttctctc 2820061 tttttctcta aatcttttac aagcactttt tttatcgtaa ccggacagcc gacctgatgc 2820121 ataagcttat cctgatggtc ttgaataatt ttaacgacac cgcttccgac ggtacctaaa 2820181 cctaaaagcc ctacacgaat cgctttcaaa aaaactccac ctttcttttg attgtcctct 2820241 tggaaaagac aattgttaac tcaacacaga catataagtt acaaacatta tataagcccg 2820301 ctcctgtttt gacaagacat cattaggctg aattttgcga atgtaaacgc ttaacgcatt 2820361 gatatgacaa gattctttat tttctaatta tttttgtcag attttctcct caccttgagc 2820421 tgcctttgcc gagccagctg acgcgtggaa caaacagctt ctgcgcccgc atattcatga 2820481 attcctgcgc tgtattgaga aattgttcat aacgcccaca gtcattaaga atgaagtcaa 2820541 gctgttcttc aaaataatgc ttttctgatt ctgatgacat gtaatagctt tctacgattt 2820601 caaaataatg aagcgggaaa agcagacggc tgtataaaag gcgtttcgaa aatgaagaca 2820661 gcggtgtgac ttgctcgtat tcctgtaaaa agagaaagcc ctgctgatta aaatcttgtc 2820721 tgtgatgcaa aaacgtatgc ctcatatatt cagccaaatc acgggaagcg tggtcaaaca 2820781 cccaatccgc cggaatcctg atcaatgatt ccggtgacca tgtatgcctt tccatccgct 2820841 gatggcatat cgttcctgaa tcagcggctt ggggcttgtc atccagctca gtgtccacta 2820901 aatattgtat cgcgttttct gacagtccta aataatatgg aaatgattcg atcatttttt 2820961 tatcgaatgg ctcatgcgga ggggtctgaa cctttctctg ccaaaatgct tccagctgat 2821021 caattcgttt tccccacaga tccttccact ggccgattct tccggccgcc ttcacctcat 2821081 atggatatcc tcggcctttt cggtgaaatt ccgcaagctc cgctccaatg gagaacgccc 2821141 tgtttgaata agggggggcc gccttcagca gagcgtacgt ttttccctca tgttcaaatg 2821201 tcagttcacc ttcttttgta aagataaaaa ccgaaacgta tgggtcactt tgttcttgta 2821261 aatactgact catgtaataa agctccgcca gctctgtttc tgagaattgg gaaacgggga 2821321 caatcagaaa gtatgaatta ggcgtctgaa agcattgata tgtgtgctgg tacatggaaa 2821381 gctgcctgat gtgaatgccg tatttttctt ttattgtacc tttcaccatg atcacctgcc 2821441 tgttgaatta gggctcatca catcgtagtc atacacagcc ggaattatga atacatattt 2821501 taatccgaag aaggcgcaag aaaaagtcgt aaacttctca agcattttgt ataaactagt 2821561 aaaaaagatt gggtgaagct gatgtcagaa aacgaacaat tcagtcagat ggaagctaaa 2821621 gcaagagcac ggatgaagga gcgcggcgtt gaggtatcag acattgccga gcttgtcttt 2821681 tttctgcaga aaaaatatca tccggattta accattgatg aatgcacgct gaacgtcaat 2821741 cgtgttctcg caaaacgcga ggtgcaaaac gcgattttaa cgggcattga attggatgtt 2821801 cttgctgagc agaaaaaatt gtctgaaccg ctgcaaacga tgctggaaat agatgaaagc 2821861 ctatatggag tagatgaagt tctggcattt tccattgtga acatttacgg atcgatcggg 2821921 tttacgaact acggttacat cgacaaagaa aaacccggaa tccttaaacg attgaatgat 2821981 aaatcaaccg gtgaatgcca taccttttta gatgacatcg tcggagcgat ttccgccgcg 2822041 gcttcaagca gacttgctca ccgcgcgcgg catacagaat aagggcaccc ttttagggcg 2822101 cccttttttc aaatgtatgg aatccattca gtcagagagt caatggcgtg agtcggtttt 2822161 tccatatcgt ctgtcatatg ttctcttttc gttacgcctg tgtgaacgag cagcgtatcc 2822221 atacccgcgt taatgccggc cataatatca gtggcgtagt tgtcgccgac catgagtgtt 2822281 tcagacacat ctgtgccgag aacgcgcatc gcctgctcca taataattga ttccggcttg 2822341 ccgataaata caggctgtac acctgtagat acggttaaca ccgatgtcag tgagccgttt 2822401 cccggcagga gccctctttc agtcggaatc gcaatatctc cgttagtgga aataaagcgg 2822461 gcgccatttc tgattgccag gcagccaaca gcaaattttt cgtatgtaat ggaacggtcg 2822521 atgccaacaa cgacaaaatc cgcgttttct ccgccaaatg tcaggccgtt ttcttcaatc 2822581 gcctggcgga ttccttcctc cccaatcaca tacacagacg cgtctttttt ctgctgtgca 2822641 atgtgctggg cagttgccat gctggtcgtg aagacctgct cttctgttgc cggaatatca 2822701 aaagacacga gcttgtccgc tacctgcttc ggtgtgcgcg aagagttgtt tgtcacgaaa 2822761 agataaggaa cgccgcgatc tttcagcgtt ctgacaaatt cacacgcctc ctcgattttt 2822821 tccgtgccat tgtacatcgt tccgtctaaa tcaattaaat accctttata tgttttcata 2822881 tccaacactc ctgtggcttt ccagttgtta tttaaacgcg gaaacaggtc ctagctctgt 2822941 ttccaaatag cttctgatcc gtttcgggaa gtcctgaaga gctgtttgat gcgccttgat 2823001 cagcctgtaa agctcgccgc tgtcagcgag cagatactgt tgaaccaacg ttttgcggta 2823061 ggcgatcaat tttttgagct catcaccctc tttttccgtg acaactttct catcaacaag 2823121 tatatccata atgtcgtcat agctgcccgg gtcccgcata ataaagccgt caatcatgtc 2823181 attgcctgta tccaaaatgc attcgattaa cagatggcct atacgctgaa gtgccaattc 2823241 cccgatttca gactgccagt ctgtttgtga gtcaaatagc gccagctggt gctcgaagaa 2823301 ccctagtgtt ttttcgattt tgcttctgtc aacaaaatac atgacagcat cccctttgtg 2823361 tatatttatt ttctgatccg tttcaagaca aaatacgcac agccgaaatt gcagtattcg 2823421 taaatatatt catctaatgt gctgattttc gtttcgaagg ttgccttttg attctggtcg 2823481 tcaaagaagc ccttgagcct taactgaccg tatccccagt ctcccacaat ataatcgtat 2823541 ttatttaata tatcggagta gcgggcttta aaagcctctt cgttgaagcc gtctttgaaa 2823601 ttgtgcacca attcaaattc ggcattttga ataagaatca tgatctcacc tcttttttca 2823661 ctcattccta tcataattca ttgccccgtc cccatcaatt gctaaagaat aaatcatgcg 2823721 atttggctac cctacacatg aggagggatt gataaatgaa acgaaccgct gtcagcctct 2823781 gcctgctgac cggactatta tccgggtgcg gaggcgcagg attggataat gcccaaaatg 2823841 tccggaatca gacgcagaat caaaccaaac ccattcatgt gtcggaccgc aacgaggctt 2823901 ttaacaggca taatgagaac gaacaatttg gctatgtccg ctatcaaaaa gaacaatttg 2823961 acggagaaca gcagaaaacg ccggtgatga accgggaaga aaccgctcac atgatatcaa 2824021 gtttaacggt tcagctcccc catattcaag atgctgcgac attggtgact gaccgagaag 2824081 cgcttgtcgt atacaaaacc gattctaaaa accgggagct gaccgccgat caggtgaaaa 2824141 aaacagcggc ttctgtgata ccgcgatact atcacgtgta tatttccgat aatccaaacc 2824201 atatgcaatc cgtcgaaaat tacagcaatc tcggctctgg ttcaagggat attagagaga 2824261 tcatgtcggg gacgattcaa gaaatgaaaa cctccccgca aggaagccct gtctcagaga 2824321 atgaaaatgc caatggagaa acgcgtcagg acatgaaaat cgataggaat gacaaaaacg 2824381 ccagatgatc tggcgttttg gcattatgct tgtgcttgac gctttttaga tgcttcgttt 2824441 acttgttcat ccgcatggta agaggaacgg acaagcggac cggcttcaca atggctgaag 2824501 cctttttgca tcgcgatttc ttttaattct gcaaattcat caggatggta gtatttttgg 2824561 actttcaagt gtttcttcgt cggctgcaga tattggccga ttgccataat atccacgttg 2824621 ttcgccaaga ggtcgtccat tacttcaata atctcttctt ttgtttcgcc gagtccgatc 2824681 atgatacttg attttgtcgg aatgtcaggc tgcatttcct tcgcacggcg caaaaattcc 2824741 aatgaacggt cgtacgtcgc acgcgcgcgg actcttggcg tcaggcggcg aaccgtttcg 2824801 atattgtgat tcaggatgtc tgggcgtgta tccatcaagg tttttaggtt atcgtagttt 2824861 ccgcccatat cagacggcag cacctcaatt gttgtgaacg ggctttttct gcggatcgca 2824921 cggacagttt ccgcgaaaat gcctgccccg ccatctttct gatcgtcacg cgcaacagcc 2824981 gtaatgaccg cgtgtttcaa attcataagc gcgactgaat ccgctacgcg ttccggctct 2825041 tgcagatcaa gctcagttgg aaggcctgtt ttgacagcac agaaacggca tgctcttgta 2825101 caaacagaac ctaaaatcat aaatgtcgct gtacgtctga ccgcccagca ttcatgaata 2825161 ttcggacact ttgcttcttc gcatacggta tgcaggttgt tttcccgcat gagttttttg 2825221 agccctgtat agttttcatt tgtatttaat ttaattttaa gccattcggg ctttctgagg 2825281 tgttcgtctt tctttgccaa ttcccatcat ctccaatatc caatatactc aatttctgac 2825341 acgaaacatt ctgaaaacga gaaaggtgca ggttttagtt ctgcaacaaa aataatgttt 2825401 ttctaactaa agaaagtctt ttctttagac actttaacat aggaaaaatt tctcgacaag 2825461 ggaagatgat tactgacatt tttaagccgg gttgccgcaa actatgtgta ttcaatatga 2825521 aaggagatta ttttgtgaaa gttttgttat ccgctcttct tctccttttg tttgcatttg 2825581 agccttctgc gtctggaaaa aaactttcag atccagtgct gtcgaaacgg atggaattat 2825641 atcataaaat cgaagctgtg acgcagatcc cttggtatgc gctcgccgct gttgatcaat 2825701 acgaagaaaa cgtgcggagc aaccggaaag atctgcctga aaaggcggga atcatcagca 2825761 tctatatacc cgatgatatc tggagcgggc ctgaaaaccc gaatccgaaa gacgatgcgc 2825821 cgttaagcat taaagtgttt gacggaatcg gaatggatgg cgatggagac gggaaagccg 2825881 aggtcagcaa cgatgaagat atcttgtata cgttcagcca atacttactg tcgtatggca 2825941 cagatgaaga caacatccgg atcgggcttt ggaattatta ccggcgtgat cagacagtgg 2826001 ggattatatc tgaattcatg aagctgttta aagcctacgg ccatattgat ctgggcgagc 2826061 atgcattccc gcttccgatc agaaccgatt acagctaccg aagcacgtgg ggagatgccc 2826121 gcggcttcgg tggaaggcgg attcatgaag gtacggatat ctttgcccat tacggccttc 2826181 ctgtcaaatc cacatgttac ggcgtagttg aaatgaaggg ctggaaccgc ttcggaggat 2826241 ggagaatcgg catcagggac attaacaata cgtatcatta ttttgcccat ctcaatgggt 2826301 ttgccaaagg gattaaaaca ggacaaatcg ttgagcctgg ccaagtgatc ggatcagtcg 2826361 gcagctccgg atacggcccg ccgggaaccg ccgggaagtt cccgccgcat ctgcactatg 2826421 gcatgtacaa agataacgga agaaccgaat ggtcatttga tccatacccg catttgaggg 2826481 cgtgggagcg atatgaatac caaaaaaaga agtaacaaaa agccgcctct tcaacaggcg 2826541 gcttatttgc tgcttttttc tttttttgaa tcggcaccgt tttctttgct gctcggaagc 2826601 tggacagaag gcgtgacacc cgagccgccg cttccattat aaaactgcgg cacttcgccc 2826661 tgcactgctt taatcgatac aggaacatta tttgtgacga cagcggtttt gctggcaaat 2826721 ggaatgatga ccttcacttt aatttcgaca aagatgctga tatcaataag tgcgttattt 2826781 atgccatacg gcttgatttt ggttttgaca tctgtaaaag cgtcaccgat taaattgaac 2826841 cggaccggga ttttcggccc gaggtttcca agaaggctgt tgccggttac ctgtcccagc 2826901 ggaatgttga tcataatgtt ttcactggcg ccgctgtgtc cggtatgggt ttccatctct 2826961 ttcaaatgag cctgaagctg ctttgtcact tttgttttca cactgtttac aacctgtgta 2827021 ttaaaatcga ttgtcgttaa gtttccgttt tcatcagaat tcatttgaaa catatctttc 2827081 atattttcac tgtcagacat atagtcctca atcgaatcct ggatcacctc tgtcgctata 2827141 cgcttcgttt ccatctcgcc gatgtccatt aaaacaggtt tgatcgagcc attgatcatc 2827201 caaaggctga ccgttgttga caggataaaa aagacaacgg acaggagcat cacgtaacgg 2827261 aaaggcaaag gtcctctctt gcgaaaaggg ccgcgatatc ttggcaagaa aatcccccct 2827321 tacatatcac aatgtatgct tgtaagaggg gacatagtaa tagccggggc caatttattt 2827381 tatttcatca tttttaaaag cgcttctctg ccgctcatgc cgactttgat gccaagatct 2827441 tccgcagcgt acgtgacgga ttctaaaggt gcgtctaaca gctggtcaat ggtgcggaca 2827501 ccaactgcgc gtcccgccac gatgccgcgc tcctttaatt tttcattcag cagcgccaca 2827561 tcaagcgcgc cgcacataat gtatccgtga tcattggcga cggccataaa attcgttttg 2827621 ggaagcttta ctgtcacagc tgtaaaaggc tgtccttcta tcatgatcgg tgtcaggttt 2827681 accacgtcaa ccactccctt cattcatcac tttatgatga agggcacagc ttgttgtggg 2827741 ctgactgcct tattgtgcaa gcttccaagc aagcagatcc cgcaaaaatt ccggcataaa 2827801 atattctttt tctgcagcgt cgcgaatcaa cggaaacagt ttgccgagcg taaacatatc 2827861 aagcaccgca acggagtatt gtttatgttt ttcaatatct tccccgttca gtgtgatccg 2827921 agtgacgtgg gtgatcccgt catcgagccg tttcgtttct acctcaacgc cggcatacac 2827981 cattttcccc atcacttctc cgcggaagcc gagtcctttg atccggagct gctccatttg 2828041 ttcggaagcg gcatggacaa tggtttcctt cagttcttct cccgtcaggc ggacagccac 2828101 cgggttgatc ggatgcggac agatgcggtg cagatccagc tttgtcacag gacctgcttt 2828161 tagcggaccg agaatgacac ctgaattgac catactgatg tccgtctcgc accattcctt 2828221 taaggcgtat gccaaaagca aaggcagctc tgattcttca aaccacttca cctcagcatc 2828281 ttgtgcaagc tctgcaacgg catcggacag tttctcctcg gcttcacgtt ctttttcatt 2828341 gagaaacgct ttagtttctg cggattctcc tgtccattcc gccatgttct gcacagaagc 2828401 cgttttgctg ttgatgcttc gctgtacgct gtccaccgtg atttctacac agccgacata 2828461 atgcccgtat ttctcggcgc tggccagcag taccccatta accacttgtc catcttcgag 2828521 caaatgatgg gtatgtgatt cgaggattac atcaatctca ggcaccgctt cagccactgc 2828581 ttgatcatca agaatgccta aatgtgacag cagaacgata atatcagcct gccctttcac 2828641 ttccagaatg gtttccttta tgctttcaag ggcatccgta actgtccatc ccagcttgtc 2828701 atatacagga taatacggca cagttacacc taagaaagca atggacatac cgtttttcaa 2828761 tgatttgata tggtaaggca ccgcccagga cggacggttt ccatttttat caaacaggtt 2828821 agagacgatg acaggaaatt cagcatgatc atataaggca gcaagctctt catgcggaag 2828881 cgtaatccct tcgttattgc cgatcgccgc tccatcaatg tgaaggcggt ttaagagatc 2828941 gacattcgct tttccgaatg tcgcctctgt cacgaattga aaacgatcaa gatgatcgcc 2829001 aatatcaaaa acgagcgtct cttcgccgtc tgactgatgc tcttttcttt tctgctcgat 2829061 ataatctaca attttcggcc agttttcaaa atggctgtgc aaatcatttg tatgatataa 2829121 gcggagcttc tccttcataa tatctctccc taatcgttca gctgaaaatg ccttcataaa 2829181 tgagctggca gccgatcaaa atcaatacga tccgcatgat cataacgatc gttttcgtct 2829241 gcatttttct gttgatggcg gcgccaagct ttccgccgaa ccaagcgccg ggcacaagcg 2829301 cgagggcgta cagccaattg acgtgcccgg aaatcatatg tgaaacagac cctgtcatag 2829361 aagacaggaa aataataaac atggacgttg ccaccgcaac cttcggcgga aacagaaata 2829421 acagcatcat cgccggaacc atcagtgatc cgccgcctat accgaaaagt ccgcctaaaa 2829481 aaccgacaac aaaggcaatg gcaataccga cagaggcctg atatgagtac gtataaggct 2829541 caccggcatc atcctgaaat gtccggataa ttcctttgtg cgctttgttg attggccggg 2829601 ctttcgcttt cagcattaag gataatgaaa tcagaatcat aaaaatgcca aaccaaacgg 2829661 aaaacgagtt tgaattgaac agctttgaca cgtaagcccc gatcatgctg ccgggacccg 2829721 aaccgataaa gaaaatgagt ccgctcttat aatcaactgt tttatattta atataagcca 2829781 aagttgaaga aaggcccgta aaaataatga ccaaaagcga agttccaatc gcaacctgcg 2829841 gcgtcacatc ctgaaacagc tgcgtcactg tgcttaaaaa catcagagat ggcacaatga 2829901 caattccgcc gccaagcccg atcagacttc ctaccgtacc tgcgattaat cccagtacga 2829961 ccaaaatcac aaacgacatc aatcaaaacc tcttttctaa aataaatcga gctgtctcgg 2830021 agcaagtccg ctgtactcga tatcaagcag ttcaagcatc tgcttgccat tatccgcagc 2830081 gtcaccgccg gaattgttgt tgaacaggac aaaaacatcc ttacattgct gctgcaattc 2830141 attcaggtgc tttttccaat cctccagctc ctgttggttg tagcggtata agtacctgac 2830201 ctcccgccag tttttcccgc catcaggctt catccagccc tgcttgttgc gtccgtgaaa 2830261 cctgacgagc gttttgtttt catcggtcgc gcgcaacacg gtcggaacgc tgccttctcc 2830321 gatttgcggt tcatcacaga cactgtgaat ccagccttcc gctttcataa atgaaagcgt 2830381 ctgctcataa aatggcggcg agaaccagga acggtttctg aattcaagcg cgcaaggaat 2830441 atctcccatt tggtgcttac accatctcaa ataggcgaca ttctccttct tgcagtcaaa 2830501 ccacggcgga aattgaaaca gcaccatggc gagcttattg ctatgtaaat atggcgttaa 2830561 agacacctta aacgcatcaa acatctcctc ttttgagtca aagggaattt cgccgcgctg 2830621 atgccctgtc atgccctgat atgctttcac gataaattgg aaggtttcgg gcgtttcctt 2830681 cacccacttt tcattattgc gcgccggctg aatcgcgtaa aagctcgcgt ctaattccac 2830741 gatcggaaaa tgggaggaat aggcctgcaa ttttttctgg ctggccgttt tcggcggata 2830801 gatgctgtca tgatcccccc atcccgtcag tccgatataa atcacactca ttcacctctc 2830861 ttccagttta tcacacgtgt tttcaggttt cctcggaaat gctgttcata tggcgggaaa 2830921 atgcctcacg caaatgctga tattgttcct cattcgtatc taaaaacgcc tcttctcttg 2830981 aggaaggaat gtgctgatat tcaataggcg cctgaaactg ctcactcgta aaatcgtaca 2831041 ccacaccatt gatgctgtta taaaaatgcc agctctcatc gactcttgtt ttgaaaatcg 2831101 tgccgccgaa atggtcttga atcaccaatg ccgtcacgcc gcattggccg catgacgggc 2831161 attcttccgt ccatttagag ctcgaatggc gcgaccagga ttgcttaagt atgtatttga 2831221 catgctccat tgcctccgcc tcctttaaaa aaagatacca cgttgatgag attttaaaaa 2831281 ctagaacgga ggaaatcaaa aaacccggcg gtaaaatccg ccgggcttac gaaggaacga 2831341 ccagagctcc gtcaatttca gtgacttttt ccccatcatt gtacacgcac cggcctttgc 2831401 tgtaagtggc cgaaatgctg cagggaaatg tatgtccttc gtaaatgctt tttttatgct 2831461 ttgcaaacat cgattctctt gtaacagtgt acggctccat gctgacgagc acgaaatctg 2831521 catcacaccc cgcctcaagc cgcccttttt tctgaaggcc gaatcgtttt gcaggggccg 2831581 ccgctgtcca ttctgcgatg gtttcaaatg gaatctgatg ctcaagcgcc agttccagca 2831641 ttcctaataa agtgaactgc ccgccgctga ttccgcccca tgataaaaac atgttatcct 2831701 cccgcttcaa ggatggacgg caaggggaat ggtctgagga aaccatgtca atgtccccgg 2831761 caatgagcgt ctcgatcagc gtctcttttg attgccgtga ccggagcgga ggcgcgcatt 2831821 ttgcgacaga gcccctttgc cgtaaatcgt catggctgaa caagacataa tgcggacatg 2831881 tttcaaccga aacatcaaga ccttcctgtt tcgcctctct gatcagccgg accgctttcg 2831941 ccgtgctgat atggacaaaa tgaaccggac agcctgtcac cttcgcatac tgaatcgtgc 2832001 gatacaccgc ttcaacttct gcttcctccg ggcgggaggc ggcgtacgca tccgcatcca 2832061 cctttccttt attggccaaa accatctgca agtagcttgt gatcgcgtcg ctttccgcgt 2832121 ggagagcgag gatttttcct gcagccgcga tttctgccat gcctttgagc aatgtccgtt 2832181 catcaacaga gcggaactca tcagtgcctg actttgataa aaacgcttta aacccgatcg 2832241 ctcccgcttc agccatcgga cggatgtcct cgatatggcc tggcacaagg ccgccccata 2832301 gcgcaaaatc cacggcagat ttttgcctgc ctagctcagc ttttgcgaga agatgctctg 2832361 ccgtcacggt tgatggaata cagttgagcg gcatatcaaa ataggtagtg caaccgcctg 2832421 cggccatcat ttgagaacct gtttcaaacc cctcccaatc ctccctgccc ggttcattaa 2832481 aatgaacatg gcaatctatc acaccaggaa acacgtattt cccgtctgcc tggatgattt 2832541 ccgtcccgct tgcttcaatg tcagaaccta tctcggcaat gacaccgttt tgaactacaa 2832601 tatcagcttc tataacgcca tctggcgtaa ctgccttcgc accttttatc accatatcgt 2832661 aagccatatt gatcccccca tgtcaggatg acgattttcc atgtcagttt atgtaacaca 2832721 accagttcta ttttcaacag tttactgcta ctatgatcgt attacatcag caaaaccgct 2832781 agaattccta ttgaaaatta ttcaccttaa ccaatgtttt tatagaaaag gagaatgcgc 2832841 tatgaatatt cttgatgtga tgaaaatacc ggcttttgaa aacgccaatt taatcgctgg 2832901 aaaagcagga ggggaaagag aggttcagca tgtcaatatg atggacgctc cggatatcgt 2832961 agactttttg cataagaatg aattgctcgt caccaccgcc tatcacctga aggatcaccc 2833021 gcatcaatta tctgaactga ttcggcaaat ggcaaaacgc ggctgcgcgg gcctcggcat 2833081 taaaacaaag cgctatctgg aagatatccc gaaggaaatc atcgaactgg ccgattcata 2833141 tgcgtttccg atcattgagc ttccggaaca catccgactc ggcgatattg tgaatgccac 2833201 actcagccat attctcgata tgcgttctaa cgagctgcag caagccattt acgcgcacaa 2833261 aaaattcaca aaccacatta tgagcggcaa ggggctgcaa tccctcctca aaaaggtgtc 2833321 agacatcctt cagcttcccg tgctgctgct tgaccagcat gccaaaatgc tgtctgcgtc 2833381 tcatcagatt tcagttgaga ccgaaaagct gaaaggcacc ctgaataccg tatccgggcc 2833441 atttttcact tgtttctcta caatctcaga tcagaaaaca tattctgtcc tgcctattta 2833501 taatcacgaa aaaaactgcg gctacctgct gatacccgac atggtgcagg caggcgacaa 2833561 aggattgatc ctcacgattg aacaagcggc caacgtcatt tcctttgaac tgctgaagga 2833621 aaatgcgctg aagcagttca gccggcgggc ccgcaatgag tttttcaaca attttattga 2833681 gcggaccttt tcttcagatg acgaaatcaa aaaccgggcg aaagaattca agctgcgctg 2833741 ggatcaaaaa tacatgtgca tcgccggcaa actcgatcgc aatgacgaat caatcagctt 2833801 tacagaaaat cagctcgctt ccgacagcgt attcgaattt cttgaaggtg aattatcagc 2833861 cttcccgttt ccacctcact tctttatgaa aggaaatgtc ggcattattc taatcgaggc 2833921 gacagacagc tggagtgaaa tgcacgcctc ggtgatcagc tttttagaac agtttcaaac 2833981 acaggtcagc gctcaattta aacgaaccgt gtcctttggc atcagcaata tctgccaaaa 2834041 gctcattgat gttcccgacg ctttcacaga agcttctgat gctctgcaat cggggcattt 2834101 gtcaagaagc accgcattta tccaggtgta tcacgccaaa gatgtgcctg agcttctgcg 2834161 cttgctccca gttgaggatt tgaagaaatt ttacaactcc acgcttcaga gcctcgctga 2834221 aaaacagcag gaggatcaaa gcctgcttca tacgctttcc gtctatttag agacacactg 2834281 ccaaatttca gagacggcaa agcgtctgta cgttcatcgc aatacggtca tataccgcct 2834341 tgaaaaatgc gaagagcttc tggggaaaag cttaaaagat cctgaaacaa cgatgcgttt 2834401 gcggcttgca ttacgtatgc agcggctgat cagctaaagt ttgttacatt ttcttacaaa 2834461 acgaatcgtt tttcgtcact ttcagcaatc acacctgtct ttttcagcta ctgtatccaa 2834521 tgacacccct cgaccggaac gatattatgt tactaaagtt cacatacagg gagggactat 2834581 agtgaaaaaa agatcgttta aggtgtttac acttagcctg cagcatgtgc tcgccatgta 2834641 tgcaggtgcg attttggtgc ccctgcttgt cggcagggcg ctgaatgtaa caactgaaca 2834701 gctgtcctac ctattggcga ttgacctgtt aacatgcggc gtcgctacgc ttttgcaaac 2834761 cttgcgcgga acatacatcg gcatcgggct tcccgtcatg cttggcagtt catttgtggc 2834821 cgtcacccca atgattgcaa tcggcagcaa ttacggcatt cacgcgattt atggttccat 2834881 cattgcggcc ggtgtgttca tctttttgtt tgcgcgtttt ttcggcaagc tgactgtgtt 2834941 atttcctcct gtcgtaacag gtaccgttgt gaccttgatc ggcctttcac ttgttccgac 2835001 aggtgtgaaa aatatggctg gcggcgaaaa aataaacggc agcgccaacc ccgaatacgg 2835061 ttcgctcgaa aaccttcttc tctctgtcgg tgtccttgtt ctgatcttag tcctcaaccg 2835121 ctttctcaaa ggatttgccc gaacactgtc cgttctgatc ggcatcgccg ccggaacagc 2835181 ggcagcagcg atcatgggca aagtcagctt ttcttctgtt acagaagcac cgttcttcca 2835241 aatcccgaag cctttttact tcggagcccc tgcgtttgaa atcggtccga tcttaacgat 2835301 gctgatcgtc ggaatcgtca ttattgtgga atcaaccggc gttttttacg caatcggaaa 2835361 gatatgcggc agacctttaa ctgacaaaga tctcgtcaaa ggctatcgag cggaaggaat 2835421 cgccattctc atcggcgggc tgttcaatgc ctttccttat aatacctttg cgcaaaacgc 2835481 cggcttattg cagctgacca aagtgaaaac aagaaacatc gtcgttaccg caggctgtat 2835541 ccttgtctgt ctcggactga ttccgaagat tgccgccctt gcatctgccg ttcctgctgc 2835601 tgtacttggc ggcgcgaccg tcgtcatgtt cggcatggtg attgcctccg gcgtcaaaat 2835661 gctcagcaca gcggatctca aaaatcaata ccacctcctg accatcgcat gctcaatcgc 2835721 actcggcatc ggcgccagca cggcccccgg gatttttgct gaattccccg ctccgatccg 2835781 gattctggtc agtgacggca ccatcaccgg aagcctaacc gccatctttt tgaatctatt 2835841 tttcagcttg cgcgacaaaa aagaattaac agcacagcaa acagaacttc cggtattaga 2835901 acatacactc gcattagaaa aagaggtgta aaaaagatga aggaacagca caatgcctta 2835961 cagctaatga tgctggggct tcagcacatg cttgccatgt atgcgggagc cattctcgtt 2836021 ccgttgatcg tcggagcagc gatcgggctg aatgcggggc agctgacgta tttaatcgcg 2836081 attgatttgt ttatgtgcgg ggcggcaact cttttgcagc tctggagaaa ccgatatttc 2836141 ggcatcggcc ttcccgttgt gctcggatgc acgtttaccg cagtcggccc gatgatttcc 2836201 atcggaagca cttacggtgt cccagcgata tatggtgcca ttatcgccgc aggactgatt 2836261 gtcgtcttag ccgcgggctt cttcgggaag cttgtccgtt tttttccgcc tgtcgtaacc 2836321 ggatcagtcg tcatgatcat cggcatcagc ctgattccaa cggcaatgaa taacctggcc 2836381 ggaggtgaag gaagcaaaga attcggctca ctcgacaacg tgctcctcgg gtttggcgtc 2836441 acagctttta tcttattgct gttttatttc tttaaaggct ttatccgctc catagcgatt 2836501 ttactcggtc ttatcgcagg aacagcggct gcatatttca tgggaaaggt cgatttttct 2836561 gaggttttgg aggcgtcttg gcttcatgtt ccgtctctgt tttatttcgg accgccaacc 2836621 tttgagctgc cggctgttgt cacgatgctt ctcgttgcaa ttgtcagcct cgttgaatcg 2836681 acaggcgttt attttgccct cgctgatatc acaaaccgca ggctgtcgga gaaggatctg 2836741 gaaaaaggct accgggcaga aggccttgcg attttgctgg gcggcttatt taacgcgttt 2836801 ccctatacag ctttctcgca gaatgtcggc atcgttcagc tctcaaagat gaaaagtgtc 2836861 aacgtcatcg ccatcacagg aatcatactg gtcgcgatcg ggctggttcc aaaagcagcg 2836921 gccctgacaa cagtgatccc caccccagtt ctcggcggcg caatgatcgt catgttcggc 2836981 atggtcattt cttacgggat caaaatgcta tccagcgttg accttgattc gcaaggcaac 2837041 ctgctgatta tcgcctcttc cgtcagcttg gggcttggcg ctacaacagt tcccgcgttg 2837101 ttttcatctc tttcgggcgc ggcctctgtc ttggcaggaa gcggaattgt gatcggcagt 2837161 ttgacggcca ttgcactgca cgcttttttt caaaccaaac agccgaatag cgcagacata 2837221 aaaacgtaaa ggaagatgcc aatgttcaca atggatgacc tgaaccaaat ggacacacaa 2837281 acactgacag acacacttgg ctctattttt gaacactctt catggattgc ggagagatcc 2837341 gcagcactac ggccgttttc gtccctttct gatcttcacc gcaaaatgac tggcattgta 2837401 aaagctgcgg atcgcgagac acagcttgat ttaatcaaaa agcatccccg gctcggaaca 2837461 aagaaaacaa tgagcgatga ctcggtacga gagcagcaga acgcagggct cggcaaatta 2837521 gaacagcagg aatacgagga gtttctcatg ctgaatgaac actattatga tcgcttcggc 2837581 tttcctttta ttttagcggt gaagggaaag acgaaacagg acattcacca agccctgctg 2837641 gcaaggcttg agagcgaacg agaaacggag ttccagcagg cccttataga aatttaccga 2837701 atcgcccgct ttcgtctggc tgacatcatc actgaaaaag gagagacgca aatgaaaaga 2837761 accatgtctt atggcaaagg aaatgtattt gcataccgaa cgtatttaaa accgctcact 2837821 ggagtgaagc aaatcccgga atcatctttt gccggaagag ataataccgt tgtcggcgtt 2837881 gatgtgacat gcgaaattgg cggagaagcc ttcctgccat catttacaga cggagacaac 2837941 actctcgtcg tggcaacgga ttcaatgaaa aactttatcc agcgccatct cgcatcctat 2838001 gaaggaacga caaccgaggg gttcctacac tatgtagctc accgattttt agatacctat 2838061 tctcatatgg acacgatcac tctgactggc gaagacattc cgtttgaagc aatgcctgca 2838121 tacgaggaga aagagctcag cacaagccgc ctcgtcttca gaagatcgcg taatgaacga 2838181 agccgctctg tgctgaaagc agaacgaagc gggaatacca taacgattac agagcaatac 2838241 agcgaaatca tggatcttca gctcgtcaag gtgagcggca actccttcgt cggcttcatc 2838301 cgggacgaat atacgactct cccggaagac ggcaaccgcc cgctgtttgt ctatttaaac 2838361 atcagctggc aatatgaaaa tacaaatgac tcatacgctt ctgatccagc acgctacgtt 2838421 gcggctgaac aagtccgcga cttagcgagc accgtttttc acgagctcga aaccccttca 2838481 atccaaaacc taatctatca tatcggctgc agaatattag cgaggttccc gcagctcact 2838541 gatgtcagct tccaatctca aaatcacacg tgggatacgg ttgtcgaaga aatcccgggc 2838601 tcaaaaggaa aagtctacac cgaaccgcgc ccgccatacg gtttccaaca ttttaccgtg 2838661 acaagagaag acgccgagaa agaaaaacag aaagccgctg aaaaatgtcg gagcctgaaa 2838721 gcctgatggg aaaactgaca acccatattt tagatttaac ctgcggcaaa ccagcggcga 2838781 acgtaaaaat tggattgaag cggctgggcg aaagtattat gaaagaggta tacactaaca 2838841 atgacggcag ggtcgatgtc cctctgctgg ctggtgaaga gctgatgtca ggagagtatg 2838901 tgatggaatt tcatgcagga gactattttg cgagtaaaaa catgaacgca gccgatcagc 2838961 cgtttttaac catcgtcacc gtccgttttc agctagcaga tccagatgca cattatcata 2839021 tcccgctctt gctgtcgccg tttggttatc aggtgtatag ggggagttaa gaaggaagcc 2839081 cgcctcaccg gcgggcttct ttttgcactt caattaactt ttgatcctag gacagtactt 2839141 gaagtgatcc ccacacttag tgaaacaaca gctagaataa acattcacct atatttttca 2839201 ggataattgc ctacgagaaa aataccctgt agtcctttca tttataaatc gaggtttcaa 2839261 actaataagt cagctcttag cagccgagct cccttctcca atcctataaa cagaccgcgt 2839321 tttttctcga aaaaatactc tgaagacaat tgctgcgttt ttaatagttt tgataacgcg 2839381 ttctctctta cacctttaga caaaatattc attttttctt ttttagactt aaatctatgt 2839441 cgaaaataat cgttggcata tcttatccta tctccactaa aggaggtgac attatgggat 2839501 tctacaattc tggtggatac agtggaaact ctggttactc aaacggtttc gggagctcct 2839561 tcgctttgat cgtggtgcta ttcattttgt tgatcattgt tggagcagct atctttaatt 2839621 attaagttta actttccttg cctccgccgt atccaacacc tccctgtccg acagacgcca 2839681 taagaagttt ttatggcgtc tttgctatgt gttcactaat ctttttgtaa tccagaagct 2839741 gtcaagttct acgagattta tcgtgtgttt tcccacaacg cttctgcgtc ttgatcgcgc 2839801 tgtctgactg aggctaaaaa agtccggctt ttaaaagccg gactcccgtc tacccccgtt 2839861 caactctctt ctaatcctgc aagctgaccg cataatcccg ccatacccgg tacaccggca 2839921 caaattcccc gccagccctt cttctatatc tttgtcagaa ggttgagggg tttcccgaaa 2839981 caatgcttta agcgcaatga tcattcccgg cgtacagtag ccgcattgga agccgccttc 2840041 ttccaggaaa gcggtttgac acatatccag ctcttctttt tgaagcccct cgatggttgt 2840101 gatggaatgg ccgtctgctt gataggccat cgtcatgcac gcattggcca gttttccgtc 2840161 gattaaaata gagcaggctc cgcagcggcc gattccgcag gacacctttg tcccggtcag 2840221 ctgaaattcc tttctaagca ggtcactcag atgtgtcgta ggaacggcag caacctccca 2840281 cgcctgacca ttcacggtca tccggaactg ttcctttttt acaggaaatg gcccggcctc 2840341 ttttatgtcc attgcttcag cccctttctg tcgatcgctt caagcaactc ttctcttgaa 2840401 attggcagct tgtttatcca gcatccgacc gcatcatgta ctgcctttac aatcgccgga 2840461 gtgatggcga ttgttccgat ttcaccaaca ccgcgcggtc catatacgtc tcccttcatt 2840521 aagtcttcta ttgcaatcag cttcatgtca ggaacatctt tgattccggg aatcaaatag 2840581 tgatcgagat tttccgcagc ataacggcca tccgtcattt tcgcttcctc catcagtgtg 2840641 tagccgagtg ccatggcagc gccgccttca atttgacctc gatatccctg cggactgaca 2840701 accggacctg ccgcaatagc gtgctcacaa tctatcaatt tgacatcgcc tgttaacaga 2840761 tctacctcca cctcaacggc agccgctcca aatgagtaga ggaaatggcc gcccaccaca 2840821 ggatcaggcg ttgttggaaa gtcaaaggcc gtttcctctg ccaaagggcc tttttcagcc 2840881 agctccttat acgtcaccac gagcgccttt gtgtttttgt cacgcaagcc tgcagcgccg 2840941 ggaataagat tttccgctga acagccgctc cattctgccg cccgtttttt caactgagct 2841001 agaaacggct tcttcaaacg ctggatcgcg tgccacacca tgcttgtgcc gcgggatgct 2841061 gtggaggagc ctgacttcgg cacttttgcg gtatccccaa taacaatgga aatatcctct 2841121 gcggcacaac ccagctcctc catgacaatc tgttcaatcg ctgctagaat cccctgtccg 2841181 cattcttcaa atccaaacga agcagtgatt ttgccttcac tcgaaagaga caaacggcct 2841241 cctgccgcat ccattcggcc aaaccccagc ccgccgccgt gcattgtaat tgccgctccc 2841301 gtgcctcttt gcagataccc gcagttccgg cttgtttttt taagaatggg agatttagat 2841361 atggcattca acacctgtgc cgctccgtca gttggtgcaa ttcgatgctc aagcggcccc 2841421 aagtcatgcg gttttctgat attttttctt ctcagctcga gcgggtcgat gccaagcatg 2841481 ccgctgagac gatcgagatg ggtttcgagt gcaaatgtga tttggttgcc gccaaagccc 2841541 cgaaattccc ccgccacccc gttgttcgta aatactgata ttccttcagt ccggatattc 2841601 ggaatacggt acggccccgc ggcatgctcg acagaaaaat caagaacagc cggtccgagc 2841661 gtagcgtaag cgcctgtgtc cgccacaatt ttcacgtcgt gcgccaatag atttcccgaa 2841721 tgatctgcac ccgtttttat cgtaatcttc atcggatggc gcttaatgcc agaacgtaca 2841781 gattcctttc gtgtctgatg aattttgaca gggcgtccgc ttttcagggc caaaagcgca 2841841 gcatacggct gaatattcag ctcatccttc cctccgaacg agccgcccat cggacttgac 2841901 acaattctga tcttctcttc aggaatatca aaaatacggg caagctggaa acggtcttta 2841961 tagccgtgct gggttcctgc atacatcgta aaacccccgt cgtcttccgg aacggctaca 2842021 cctccctccg tttccatata cgtatgcatc tgccgcggca gctcataggt ttcttcaaag 2842081 actgtgtcag atgcttgaaa cccttcttcc acatcaccgt ttgaaaaaaa tgcgcggtgc 2842141 aggatattcc cgtcctcatg cagtctttgc gcattcggcc gaagcgcttt ttctggtgaa 2842201 tccatgactt ccagctcttt atactcaact tgaatcagct ccagcgccgc ttccgcgatt 2842261 tcttccgttt ccgcagcaac tgcggcgatc gcatccccga cataccgcac cctgtcctca 2842321 cataaaaccg gctgatcagg gatgacaatg ccaaatcggt ttaagccggg aacgtcttta 2842381 tgtgtgacga cggcctgcac gccttccatt ttctcagctt ttatggtgca aaccgacaca 2842441 atctctgcat gaggataagc acttctcagc accttgccat acagcattcc tggaaagctg 2842501 agatcggtca tatatttcaa ttcccctgtg accttacccc ttccatccgg cctgactctt 2842561 gacggtttgt tgatgatcat ttattcccct ccctcagcca tcagctctgc catgatgacg 2842621 ttggcagcgg ctttttttct gtatgccgct gacataaaaa catctgagga aaacggcagc 2842681 tcatggataa gtgttttgta cagctcatgc gggtcccacc ctggtgccat ccatttcgct 2842741 tcgctgtcca ataatctcct aggagtgata tcggcatggc cagcggcgag gcgaatgctg 2842801 ccgtctttca aaaaacgtcc agctgcaaca gcagccgctc cggtaaaagc ctggcgcctt 2842861 ccaagcttgt gataaaatac acgctctccc tccgcccgcg ggatgatgac acgcgtgacg 2842921 atagccgttc taaagtcttc ctcactgagc caagcgccaa gcggcagcct gattagctcc 2842981 ttttgatata cgataagctc agcaccaagc acaagcagaa gcggaatgaa atcaccgatt 2843041 ttactcgcta tgttgccgcc aatcgtggca cggctgcgaa tccccggtgc agcgacagcg 2843101 gaagcagcgt cactgaaaca gctaagcgct ctcttaatca aagggttctt tctgcattca 2843161 ttcagtgatg tgagcccccc gatcgacacg tgggtgtcac tggtgctgat ccctcgcatt 2843221 tcgtcaatcc cttcaaggct gacaaggtgc tgtttcggta gagttccttt gtcccactga 2843281 agctgaagga gcgtgcttcc cgatgcggca cacacatccg gagcaagctt ctctaaaagc 2843341 gaataggcct catcaagcgc tgccggtctc cataattgaa tattcatcct tgcttttgtc 2843401 acttggccgt tcaagacatc gccctcctta ccatgtcata ttcctcgggt gtatcaatat 2843461 cgtccaactc accgctatcc tttgcctcca aaaccgctcc tgctccaagc tgtccgcttt 2843521 tcaggagcct gcgagcccct tcatctccct ttaatccctt tacataagga aaacatgtcg 2843581 acgagaagta gattggcggg gtgaacgccc ctaaaaacga tgacacggca aatgactcag 2843641 gagccagagc cacaagggca ttgagatgat cgacggaaag ctgaggctgg tcggctaaca 2843701 aaatgacaat gccgtccgcc cccatgcttt ctgcttttct caccccgctg ctgactgaat 2843761 gcccctgacc cttttctgcg tcttggcaaa cgtgcaggct ccagcgtttt tgaaaaggcg 2843821 gagcgtgata cggcgctcct atccactcaa gggaggcatg ttctgtccgc tcgacgacca 2843881 gcacgtgatc aaggcgggac gacagagcag ttttcaagga aagtgagcct atgttttctc 2843941 cttttagcgg caaagccagc ttgttttgtc ccattcttct gcttttgccg gcagcgagaa 2844001 acacgccgat cagatagggg cttctcatac aaccgccacc cgttttcttg tttgaatgat 2844061 ttctgcaact acacttaccg caatttcctc gggaccttcc gcaccgattt tcagcccgac 2844121 cggactgtaa aagtgagacg gaggatgttt tccgctcagc agccgtttcg tgcggtttgc 2844181 cgaacccaac agtccaatat aatggaggtt ttgagaaaat aagaagttga tgatcgtttg 2844241 atcgtgctga taatgatggg ttgccacaac agctgcatca tgcggaaaaa attgaaattc 2844301 gctaagcatt tgttccggaa aagcggtgat cagctgatcc gcttttggaa aaagagagga 2844361 tgtacaataa gcgggccgcc aatccgtcac gataacagaa aaccctgtgt cagccgccaa 2844421 attggccagc ggtacattat ccggtcccgc cccaaacaga atgagacgcg gcttcggttc 2844481 aattcgctga ataaacatgt tagtggtttg atcgaaatgc ggtaaatgaa gcgttgaaac 2844541 agtacgttga atatcttgca gaggcgcgtc cggccagttc ccaaaatgtc cgttctccgt 2844601 cagaaataaa taatgggagg attcaatctt tataacggaa gtgacagctt tgcctgaatg 2844661 aaggcagtcc ctcactttct catagtgccg ccttttttcc tgagtgattc gctctgcatg 2844721 aacatgaata atgccattgc acccggctcc catgccccaa gaaagatcgt cctccgaccg 2844781 catgtcgtag ggaatcagcg ttgatgtgag ctgatcgccc agcgcactga ttctttggaa 2844841 tacatcttct tccacacacc cgccgctcag caagccaatc cgtctgcctt ttttcttaaa 2844901 gagcatagag gcgcctgctt ttcgatacgc ggagccttca acttgaacaa ttgtcgccag 2844961 tacagcctcc tcctggtctt ccaggagcgc atctaacatc gtgtgaaaat tccccaatgc 2845021 cgcatcctcc tctcgaaaat tgccgtgaga aacaactagt tcagcgtgat tttataggta 2845081 acttgtataa agaatagacg atggaagaaa aaatgactca tgatttgtca gaaaatgaaa 2845141 cacatagaaa gaggatttgt aaaaagagtc aaacgaagaa aatcagattg gagaaaacac 2845201 gaaatcatat cgttaaaaag cttgcggagt tccgcaagct tttctttaca ccgctgcctg 2845261 gcggccagcg ttttcataca catccagcgc tgcttggagc gcttttcctg cttcgattcc 2845321 tgcgttatgt ctgagaagca cagcctctaa cccggcaagc acgaatagca cgttttcttt 2845381 tctgcagctg taccccatcg tgccgatcct ccagatcttc cctgcaagcg ggccgaatga 2845441 gctggcgatt tcaatgccga attgtgccag cagcatgtca cggacagact cgccgtcaat 2845501 gccgccggga atttcgacac aggtgacaac aggcattttg cagctgtcat ctccaaacaa 2845561 tcttagcccc attgccttta tccctgctgc taatgcggct tcatggtgcc gatgccgctc 2845621 gaaacgcgtc tcaagacctt cttcaagcac cagtctgact ccctcacgta aggcgtacag 2845681 catcgtcgtc gcttctgtat gatgattgag ccgtctttcg ctccaataat cctcaagctg 2845741 gctcaaatca aagtagttgc ttgtaattgg ccgatttccc gaaagtgctg ccctgtcagc 2845801 ttgtgtcgca atcccgcgtt ccaccttttt gcgagctgca atcacgtccg ccacccgctc 2845861 attatatgta atcggcgcca ttcctgaagg cacagacaaa catttttgcg ttccgccgat 2845921 ggcagcgtca atcttccatt catcgacttt aacctcgcag cccccaatcg ttgcgactgc 2845981 atcgacgata aacaatgcat cctcggtgcg gcaggcttcg ccgatggctt tcagcgggtg 2846041 aatccgtcct gtcgatgttt ctccatgcac catggccaca attttcggct tcactttttt 2846101 tatctcccgt atgatgtcct ccgggtcaaa aaccgttccc cattcgcact ccagcatatg 2846161 aacatttgcc ccatatcgct cggcgatttc agtcagcaaa taaccgaaac ggccgtaaat 2846221 gggaatgagc acatcatctt ccggctctat cacactagcc agcactgctt caattcccgc 2846281 ccgtgaagtg ccgtcaatcg ggtatgccca gcggtttttt gtttggaaca gctcccgaag 2846341 catctccatc gtttcattca taatacctgt aaacgccgga tcaaattggc cgacaaccgg 2846401 ggtgctcatt actcttaata cacgcggatc aacctcaaca ggccccggtg tcataatcgt 2846461 tcttaacggg gtgcataatt ctcttctgcc tgacacagcc attcctcctt tatcagtaag 2846521 ccagtttgta taataaatca gtcagtgcgc ggacgccgat ctcaagctgt ctggctgacg 2846581 tatattcctt cggtgagtgg ctgacgccgc ctcggctcgg cacaaacagc atacaagcag 2846641 gatagcgcct tccgatcatt tgcgcgtcat gccctgctcc gctcaccatt tcctcacagc 2846701 tgaagccgtt ttctaatgct gtttcaaaag ccgcagcctt cagcctttcg tccatcggca 2846761 caggctctat ccgcatatat tcatcaatca cagcgcgaat tcctttttgt aggcaaatgc 2846821 cgttgatcaa agcaaccatg tcttgatgaa actgttccag cacatgctga tgctgatggc 2846881 gaatatcgat tgaaaactgg acgcggcccg gtatgacatt ggctacattg ggctctgccg 2846941 ttatttttcc gcatgtcaga cggagctcat ccggcagctc atccgaccgc agcagcagct 2847001 catgaatgat acggctgctg gctgcgagcg ggtccttgcg ccatttcatg gaggtggttc 2847061 ctgcgtgatt gcattctcct tcgagcgtga cgagatatcg tctctgcccc gcaatacttg 2847121 tcacgatgcc gagatcccgg cctgacattt ccaacgtctt cccctgttca atatgcagct 2847181 caacaaacgc gctgatatct gtcctatatg ctgactgaaa cacacctttg ccaaaaccgc 2847241 tctcatgcat cgctgtttgg agggagactc ccgactcgtc tcttggctct tttgcatctt 2847301 gttctgaaaa aacacccgtc atattccccg acccccaata ggtcattgga aaacggctgc 2847361 cttcctcctc acataaggag accgcctcga gcgttttttt tggcgctccg tatgtttcct 2847421 tgagctgctt taacgcgagc attgccgcca gaacgccata ggcgccgtcg tattttcctc 2847481 cattgatgac agtatcgata tgtgaaccgg ttacaatgac ttcatccgga gactgggtgc 2847541 ccgaaagcct tccaaacaca ttgccgacat cgtcgaatct tgtttcaagc ccgaaagaag 2847601 acatttccgt tttcacagca agctgtgcgt ccatccactc ttttgtgtat aaaagcctcg 2847661 ttacgccgcc atccgcagac gcaccgtatt gggcgagcca ttcaatataa tctgtgatgc 2847721 tgttttttac tgaaagcttc tgcttttcca tgtactcccc cctctggccg ctatggtgac 2847781 ttcattatag aaggagcaac atgatagttc attgacagat taaccaaaaa aacgtttatt 2847841 ttttagccac agtatccatc cagcaaccag atacacccta catgtcacaa ctattttgat 2847901 gtaaaggtca aaagaaaaca cggtaaggaa gagagccagc aagagcgaaa gagagggtca 2847961 aaatgccttt catatgaaca agctaagctg gagaggcgat gttcgcggaa cggatgaaaa 2848021 cagaaatgcc ggcagcccgc aaaaacagga cctaaagata tggaaacagg agatttccgc 2848081 ctcctccaaa gggactaatt tacaatttta atgaaaaata tacaaaatga cacttctatc 2848141 ctttatttca attttagata atagatatga tctgataaaa ggagggcaag tgatgacaaa 2848201 aaaagcatgg tttctgccgc tcgtctgtgt attactgatt tccggatggc ttgcgccagc 2848261 agcttcagca agcgcgcaaa ccacattaag ccttaatgac cgattggcgt cttccccttc 2848321 aggaacggga agccttctct cattagccgc ccccgctgca ccctatgctg acacagatac 2848381 ctattatgaa ggggctgaag gtaaaacagg agactcgcta aaaagcaccc tgcaccgtat 2848441 tatcagcgga cacacgatgc tgtcctacag cgaagtgtgg aacgcgctga aagaaacgga 2848501 tgaagaccca agaaatccga ataacgtcat cctgctctat acgaatgaat cgcgttccaa 2848561 aaacctgaac ggcggcaatg tcggcgattg gaaccgcgag catgtctggg cgaaatccca 2848621 tggcgatttt ggtacgagca agggacctgg tactgatatt catcatttgc gcccggctga 2848681 tgttcaagtt aacagcgcca gaggaaatat ggattttgac aatggcggca ctgaatatgc 2848741 gaaggcaccc ggaaattatt atgacggcga ttcatgggag ccccgcgatg atgtgaaagg 2848801 cgatgttgcc cgcatgctgt tttacatggc tgtccgttac gagggtgatg acggctatcc 2848861 tgatcttgag cttaatgata agacaggcaa cggctcagct ccttatcatg gcaaacaatc 2848921 tgtcctgctc gaatggaata agcaggatcc ggttgacgac cgcgagcgga aaagaaatga 2848981 aatcatttat gaaaaatatc agcacaaccg caatccattt atcgaccacc ctgaatgggc 2849041 ggatgagatt tggccgtaag aaaaaggtgc tccttttgag gagcaccttt ttctaataca 2849101 cagcctcttc cgtttccgca tcgaaaaaga cgacgtggtc cattttcact gagagctgga 2849161 ttgaatcgcc tgcatcgatt cgcgtgtttc cgtccaggcg gaccttgagc cgctcgtccc 2849221 cagccatgac atgcactatg agctccgagc ccagattttc attcacttcc acgttcgctt 2849281 gaaacactga atcaaacaac tggtcatttc ctgtcatttg tgtgatgtgc tccggccgta 2849341 caccggcaat catctgttct ccggcatatc ccttttcctt cagccgcttt gctttttctt 2849401 caggaatatg aagccggatc gaagaatttg tgaaaaacag ctcgccatgc tgctgttcta 2849461 tgatgccttt caaaaagttc attccgggag agccaatgaa gcctgcgaca aacaaattgg 2849521 ccgggtaatg ataaatgtca tgaggtttcg ccacttgctg aatttcccct tcattcatga 2849581 cgacaatccg atctcccatt gtcattgctt cggtctggtc atgcgtgaca taaatgatcg 2849641 ttgcctctaa tcgctggtgc agcttgctga tttctgtccg catcgtcact cttagttttg 2849701 catccagatt agaaagcggc tcgtccatta aaaagacctt cggctccctc acaatcgacc 2849761 tgccaagcgc caccctttgc cgctgcccgc cggagagcgc cttcggtttt ctcttcagca 2849821 aatgttcaat ttctaaaatt ctggctgccg catgaacccg ctcggcaatt tcctgtttcg 2849881 ccatctttct gagctttaat ccaaacgcca tattatcaaa aaccgtcata tgcggataaa 2849941 gcgcatagtt ctggaatacc atcgcaatat cacgttcttt cggcggaaga tcattgaccc 2850001 gctccccatc aataagaaga tttccttcag aaatgctttc taatccagcc accatccgca 2850061 gcgttgttga ttttccgcat cctgacggcc ccaccagcac caaaagctcc ttatccttta 2850121 catctaaatc aaagtccttc acggttaatt gtgagtgata tgattttttg acgtgttcaa 2850181 atgttaatga agccatcaga aaagtccccc tatcttttga cccgttattt cgtcactgga 2850241 aacaacttgg tctttctgtt atttttagag taatcgattc ccatttttgc tatatttcta 2850301 aaataaaaaa tgtaaatttg tattataacg tcataataca ttataatata aataataggt 2850361 taaaaggagg ctaccctttg ttaaacaacg gaagttctac acctttatac attcagctaa 2850421 aacaaatcat cactgatgac atcaaaaagg gcgtgtattc cccaaccgcc aagctgccta 2850481 ccgaaaacga gctttgcacc aagtataacg tcagccgcat caccgtcagg aaagccattc 2850541 tcgatttagt cgaagaaggc tatctgatca ggcagcaggg aaagggaacg ttcgttaaaa 2850601 gccctaaatt aaaacgagag ctgatcgctg taaacggcta ctcggaattt atggaatcaa 2850661 ccggcaaaaa accgaagcat catgtgctgt cccatgacat cattccagcg tcaaaaccca 2850721 tcgccgaaaa gcttcaaatc caacccgaga gccctgtggt tgaattaaaa cggattttat 2850781 ataatgatga tcagcctctc acctttgaag tgacgcatta tccgcttgat ttgtttcccg 2850841 gcattgatac ctttattgct gacggcgtct ccatgcatga tattttgaaa cagcaataca 2850901 aagttgtacc cacgcacaat acgaagctat taaacgttgt atatgcccaa caggaggaaa 2850961 gcaaatacct ggattgtgat atcggggatg cgctgtttga aattgataaa acggctttta 2851021 catcaaacga ccagccaatc tattgctcat tgtttttgat gcacacaaac cgtgtcactt 2851081 ttaccatcaa cagcccctac acataacagg cataaaaaac gagacactgc ttatagtatt 2851141 ctcgtttttt cactgcttcc cccgtcctcc aagcgataag gatagccata gccgaaagct 2851201 ccgtacacac cgcaagtttt cgcagccgtt tcagcagcct ggcgcaaagc atacgttata 2851261 tcctgcttca cgcaaaaggc agtcaaaaag cctgctataa aagaatctcc cgctccaagt 2851321 gtatctatta tatcagcttc cacaatcggc tgatgataga ctcgatcacc cgcagacagg 2851381 attgctcctt ggccccctcg ggtcatacaa accattttgg ctccgtaccc atgagctgtt 2851441 ttggcaagct caccgcattc cgactcactc aaatcgcttc ctgaaaaaaa cgcatacgtc 2851501 acataaggac agaccctcct caaataatca tcctcccgat tggttgaaaa atcaaatgag 2851561 accgggacca gcccgcacag ctgcggaaga tcgttctcaa gcctgctgta cacgctcgta 2851621 tgcagcagat catgcccgct gataaaagat acatctttct cctgaaacgc gaggcgaagc 2851681 cgggactgaa tgccgccttt atttgatctg acaaaaatgc ggtccccctg ttcatcaagg 2851741 gtgacaatcg ccatcccgtt ttctccgtgc gcctggcgga tataatctgc attgacctgc 2851801 tccagcttga gaacgttcaa cagatgcgcc gcggcttcgt cattgccgac gattccgata 2851861 taggaagact catgcccgag ccgcttggca agcacagcaa cgtttaaggc atttcctccc 2851921 gggtaaaatg tttcttgatc ctggtagtaa tctacaacat tatctccaac cgcaatcaat 2851981 ttcatagcgc ttcctccttt atccttttac actgccgctt gcaatcccgc ggacaaaata 2852041 tttctgcatc aataaaaata gaataataat cggcgcggct gaaatcgtta accccgccag 2852101 caggacgccc cagtctgtct gcagcgcgtc tctgaactgc atcagcccgg ctggaatggt 2852161 ccgtaaattc tcatcatcta tgaaaataat cgcaaacata aactcattcc atgtatggta 2852221 agccgtcaaa atgccggatg tcaccaaaat cggcacgctc attggtaaga aaattctgaa 2852281 aaatactcca aaacttgtac acccatccaa ataggccgcc tcctccaatt cttttgaaat 2852341 agaaagaaaa taagagcgga tcaaaatgat ggtgaatggg atccgataag ccgcatacgg 2852401 caagattaac gcccaatacg tattgtacag gcccagcgac tgaataatag aataaagcgg 2852461 cacaagactg acctgcggcg tcagcatcaa tccgccaaga catagcacca aaaagaatcc 2852521 ttttccttta aactcaaacc gggaaaggcc atacgctgcc catgcactga taaagacagt 2852581 gatcacacac gtcagcgccg taacgatgac actgttcata aaataagaag aaatcccctg 2852641 attccaggcg gaaacaaaat tttccggatg ccacgaagac ggcagcgacc agctgtgctc 2852701 aaaaatatcg tcagagtttt taaaggcgct catcaccatc cagagaagcg gataggcaat 2852761 cgcaatcaga taaagaaaca gaaaaaccca cacagacgtt tctccgatat accattttcg 2852821 tctaggctta tctttcacct caatgtgctg gtcaggcacc ggctccaatc tgaacgaatc 2852881 tgtcttcttc tgaggcagca tcagttactc ctcctttccg gttttaaaga acttcatttg 2852941 catgagcgat aatgcaagcg taatgattaa cacgacagtg gcaatcgctg aggcgtagcc 2853001 catcatatcc tttgtaaagg cgcttttata taaaaacgtg ctcaagactt ctgacgcttt 2853061 tcccggcccg ccgcctgtca aaatgtacgg ctcattaaag accgtaaagg ctccggtcag 2853121 cgtcatgacc accgcaacaa aagacatctc tttcgtctgg ggaacagtaa tatgaaaaaa 2853181 ctgctgaatt ttacccgcgc cgtcaagccg ggccgcttca tacagttcat ccggtatttt 2853241 ttgaatcgac acgatgtaca gcatcgcaat ataaccgaca gattgccact gggacacaaa 2853301 aatgacagaa agcatagctg tgctgtcatc cccgagccag gccctcgtca gctgatcaag 2853361 accgatggcc tgaagcagct gattcaaaag ccctgtctcc ggattgtaaa taaaatcaaa 2853421 caaaagcgcg atcaccgtca ttgagatgac aaccggcaaa aagaaaacgg tacgaaaaaa 2853481 cggcgaccat tttctgacca gcttatcctc aagcaccgcc gccaaaatca aaccgccaaa 2853541 tacctggcat acaattgaga tcactgcata aagcacatta ttggtaagtg cctgatagaa 2853601 gacaggatca tgaaataatt caacatagtt ttttaagccg ataaacgttt tttccggaga 2853661 aaatgagctc cactgaaaca ggctgaggaa tacattctca aaaatcggga tataaacgaa 2853721 aagtaaaaaa acgagagcgg gcaccaaaaa caaatagggg attattttat tctgattgac 2853781 caagggtatc tcatctcctt tataaaaaga aaaggtgcga agcttcacct tttctttgat 2853841 ttattcagct gacgccctca cctgctttgc tgccttttga acggctttca tcacctgctg 2853901 cggtgtcatg tcgccgccaa gcatttgctg gacgcccgtt aggtacgcat ctgcgacttc 2853961 aacatcgaca tccatatcaa accatggaac cattgatttg gcatcaacaa tatgctgaac 2854021 ggcttcacgc tgaatggctg ttgcattttc ttcagtagcc gtaccttgca ctgcactgta 2854081 tttcccgaca tctttcacga gcttttcgcc cattcttttc gacgtcaaga actgcaaaaa 2854141 ttccatcgct tccttcggat gttttgttct tgaggagatc atgaatcctt ccggcgctcc 2854201 cgttaacgct tctgaagatc ctttctgccc gctgatttca ggaaatggga acatcccgag 2854261 attaaccggt tcaaccagct tgatttccgc tgtttccgca tatatcatcg ccgactttcc 2854321 gctcttaaat tgctgtctca catattcgtg gtcgacggag tttacatgtt tattaaagta 2854381 aggcatcagc tcttgaagct tttcaagtgc ttttacgtag ccttcatcag taaattcacc 2854441 cgttttggcg ttatagtcct tttcccgtgt tttttcatcg accatccgct gattaagcgt 2854501 gccgatatag tgcgagattg tccaagtcgc ctttgttcca aagctgatcg gtgtgtagcc 2854561 atgttctttc agcttttttg acacatcgat taattcatcc cacgtcttcg ggggatcaag 2854621 attcagcttt tggaaaatgt ctttattata gaagaatgat ttagcgtcca tttgccacgg 2854681 tacgccatat tgcttgtttt cataagtaaa tggtgtaatt tgcgattgaa cgagctgtga 2854741 tgaccaatcg gtgtcatttt tgtagtagga cgagagatca agtgctttat tgcctctgat 2854801 aaatttaaaa gcaaactcat cgctccaaga gaagtaaatg tcaggagggc tggtggttcc 2854861 cagcatgacc ttaattttat ctttatagga gtcatttaaa acggcttcaa tttgaatgtc 2854921 gatatctggg tgatcttttt caaattcctt aacaacctct tcaaaataac ttttttccgg 2854981 ctcctttggc catctgtgga aaaatttcaa tgtcaccttt ccgtccgctg aactgctttg 2855041 gctcgaacag cctgcgatgg tgagcatact gacagctgca atgatcaaga acaacaacat 2855101 tttcttcaaa gggttggcct cctctggaca ttagactata atgttatata acattatagt 2855161 ctaatgcata atggttcttc attttcagat caatactcaa ctttccacat gtatcttcta 2855221 tgagataaag gatgatttct ctcctctgcc agctcgtctg catagcttct cagcacacga 2855281 ttgagaacga gcggagcaag atagccttta actgaatcgt caattgcagt gaagtcgtaa 2855341 gatgcagcat caagcacagt gagctttttg ccatactttt tcgagaaggt aagcgcccgc 2855401 tcttcaagag gtcttgtttc atctaaaccg agcaggatga taaacggcac ggattcatca 2855461 ataatttcaa acggtccgtg aaaatattct ccggcatgaa tggcgtggga atgaatccat 2855521 tgcatttcca tgagaatgca gatgctgtag gagtaagcga caccgtagtt tgcaccgctt 2855581 gccatggtat aaataatgct ttctttttca tgggcttttg caaattgctt ggcgttgtca 2855641 gcttcctgct taagggcttt ttcatataca gcctgcaatt gatctaagcc ttcaattgct 2855701 tgctcaaatt tcgtattgtt ttctaatact tgcagggttc caaaaacgat ttgatacaaa 2855761 acgccatagt ttgtattgat cgcaagcgcc tcatcacccc aatcgtactg ggcaacatat 2855821 tgcgcttcct gcgctaaagg agactccggt ttaaacgtca tcgcaatcgt aagtgcgccc 2855881 ttgccccttg caaacgcagc agctttgact gtctccgggg tatttcccga atgcgagcac 2855941 aaaataacaa gagacttttc accaagctga acagggttgc gctgaataaa ttcgttggcg 2856001 ctgtagagat cggagtttat tgattttgac tctctgtcaa acacatactt actcggatac 2856061 ataatggcag aagaccctcc gcatgcgaca aagaatacat gatcaatggt tttccctttc 2856121 aaatcctgca agaaagcttg aacctcacga tttacttttg ctgtggcctg actcaaatcc 2856181 ttcactcctc gtttttatta tataacgtta tataacatta tatattgtta tattaaagtc 2856241 cgcgggtagg attgtcaata ttattttctg aaatttctca ataatttatt cggatgacag 2856301 acaaagggtc tatatgcgaa aaaatgccca aatcaaaagc cagaacttga cttaagctct 2856361 ggcttcgctg ttcaatccgc agactgacgt cttatttaaa aaataccttg tctatattgt 2856421 acttcgagtg ctgtgtattg atgatatatg tttcgtaaat ctctctttcc attggatcat 2856481 caactacaca tacctcaatt ttataaactt catctctgtg atgtttgatc ggtgaaacag 2856541 tgtcttcgaa atgcttctta attctctgtc ttaactttct ggctttaccg acaaacagca 2856601 gctcgtcatg aatgttgtaa aacataaaaa tgccgccttt gtcccttggg atctggtgaa 2856661 agtcgatgaa tccgtgaatc ggttttatct tcggctcgtt atcattagct gactgctgtc 2856721 gttcagtgat ggtgacattc ggtgcgggta tatcaatttt tatcaaaatc agttcacgtc 2856781 ctctttttca ttaaagataa atgctaacac atacagaaaa gaaaagctag aacagcttta 2856841 ttatatttgt ttgtcatgct cttacttatt atgcaagtgc tccggctgga tcataaggac 2856901 taaggtctaa ttctgtctgc tttccgagaa ctagctttgc gagctctgca cccaaaaacg 2856961 gccccatcgt cagtccagaa gcacccaaac cgtttgcagc gtacaggcct tgaacattcg 2857021 gcacggcccc tacgaccggc agaaatcccg gtgtaaacgg cctgaagccc actcttgttt 2857081 caacagcagc cgcatcagca agacccggtg caacggctaa cgctttgctc aatacttcgt 2857141 gctggcctcc ggctgtcaca cgaagatcat caagaccggc atcgttttcg tgtgtggcgc 2857201 cggctacaat tctgccgtta tcaaacgaca gaatgtactg atcactcggc ggcattacaa 2857261 ccggccacga tcctgtatct gcatctgtca tttcaaaatg cataatctgc gctttttgaa 2857321 atgacacttg aaaatgaatg ccaagaggct tcaatatctc attggcccat gctcccgccg 2857381 tcacaatgac cgcgtcagcc gcaaactgct ttgtatctgt ttgcacgccg gtgactgttc 2857441 cgttttcaaa aagcaaggac gcatttcctt tgatgaccgt tgcgccgcgt ttctctgcag 2857501 cgcttaaaag cgaccggcac agcgctcttc cgttcacacg ggcggcaccg ctgatatgaa 2857561 ccgattcata gccgtcagct aaaatcggaa acagcttttt cgtttcactt gcagacaagc 2857621 gggtaatgtc gccgatttcc ggcgcatcct cccgtctctt atacgccctt tcctccattt 2857681 tatcgagttt agacgcgtca gtatgaatgc tgatggcacc gacacgtttg tatcctgtat 2857741 ccgattcacc gtctttttcc aattgatgga ttaaatcctt atagtaccgc gctcccccct 2857801 tagcaagctg gtaccaatcc tgattacggc gctgcgagag ccaaggacag acgatccccg 2857861 ccgccgcatc agtcgcttgt cccggctctt tccgatcaat gacagtaacg cgagcgcctg 2857921 tttttgcgag atgataagcc gtcgacgcgc ccagaatccc tgcgccgacg atgatgtacg 2857981 atttcatatg caaacacctt ttctattata atgtctattc attttaccaa atcaaatgct 2858041 ttccttcgac cttttgccct aatgtggaaa aaccgcgaag ttcgtccaat ctctttactc 2858101 tcctatcgaa tatcctgtca ctatcaatag agaaaggatg ataccatgag cgaaaatcgt 2858161 catgaaaatg aagaaaacag acgcgatgcg gcagtggcaa aagtccaaaa cagcggtaat 2858221 gcaaaagtcg tggtcagcgt gaacacagat caggatcagg cacaggcgca gtcacaagac 2858281 ggagaagact aatgaacgaa aacatcattc ctcttaacag acatactcaa gagataccca 2858341 ctactgaatc tgttatcaaa aacagcggca actcagaggt ccatatcgac attcacattg 2858401 atacaatgcc aattgctttt gctatattat gctctgcatt agccgcaaag cagatgacaa 2858461 aagaggaatt cgatatggct tatactcaat tgcgagagat gaacagagaa aataacagca 2858521 gatcatctgt aaagcaaatt atcaatcaag agacagaaga agagtaaaaa accgcggccc 2858581 ctcggccagc ggtttttctt ctgcatacaa aaaggacgcg actgaatcgg ttacttctgt 2858641 acaatttgaa taaggttacc gcatgtatcg tcgaagacag ctattgtgac ttcgcccatt 2858701 tttgtcggtt ccgtcgtaaa cgtcacgcct ttttccttta atcggttgta ctctttttga 2858761 atatctgcaa cgccaaacat tgtggccggg aggccttcgg agaatatctt cttttgatac 2858821 tccttggcgg caggatgttc attcggttcg agtaaaagct cggttccgtc ttgatcatct 2858881 ggagaaacaa gcgttatcca cctgaatttc cccatgggaa cgtcttcctt ttttataaac 2858941 ccaagttttt ctgtataaaa ctccagtgcc atgtcttgat cttgtacaaa tatactggta 2859001 acaacgattt tcatactgtt tttccctcct tcgatatgaa tgaagcatgg tactatgcta 2859061 acaatctggc tacaagcaaa acaacccaca catttatcag aggccctgtt ctgattttat 2859121 aaaattattc tatccatcct ttcagcaaat ttttaagcgg ttcgttgttg aatataagta 2859181 ctcgatattt tccctttcgt tttgatgtta cgagtcctgc atcctccagt acagaaaggt 2859241 gtttagctat cgcctgtcgc gtaatagaaa ggtcgtactt tgtaataaga cgtatcgtaa 2859301 gttcatacaa cgtcagctcg ttgcgttcag ataattcgtc taatataagc cgccgagtcg 2859361 aatcgccgag tgctttgaat atagcgtctt tgttcccatt catatattga gtataagcaa 2859421 cccattagtt gcatgtcaag tataagcaac tgtatggttg cgtgatatag aaactgaacc 2859481 tatccggcgc aggtctgaaa tattctaatc gataaggaat taaaaccatt aaaataacag 2859541 tggatatgtc tctgaaaaat aaaagaagac gaacttcaaa agttcgtctt ctacaatcaa 2859601 attcggcacg ccggccattt taaagttgat aactatctct aaaccccttg ataaacaaag 2859661 gagttttcat cattaaccga tagaaccttc catttcgaac ttaatcaaac ggttcatttc 2859721 aactgcgtat tccatcggaa gctcttttgt gaatggctcg ataaagccca ttacgatcat 2859781 ttcagttgct tcttcttcag aaataccgcg gctcatcaag tagaagagct gctcttcaga 2859841 tactttagac actttcgctt cgtgctccaa tgaaatgtta tcatttaaga tttcattgta 2859901 aggaattgtg tcagaagttg atttgttatc cataatgagc gtatcacact cgatgttaga 2859961 gcgggcgcct tccgctttgc gtccgaagtg gacgattccg cggtacgtta cttttccgcc 2860021 ctgttttgaa atcgattttg atacgattgt agatgatgtg tttggtgcaa ggtgaatcat 2860081 tttcgcacct gcatcctgat gctggccttt acccgcaaga gcgatagaaa gcgtcatacc 2860141 gcgcgcgcct tcgcctttta ggatacaagc cggatatttc attgtcagct tagaaccgat 2860201 gttgccgtcg atccattcca ttgttgcgtt ttcttcacag actgtacgct ttgttacaag 2860261 gttgtaaacg ttgttcgccc agttttggat cgttgtataa cggcagtagc cgcctttttt 2860321 cacgatgatc tcaacgaccg cactgtgaag tgagtttgtt gtgtaaacag gcgcagtaca 2860381 gccttcaaca taatgaacgc ttgcttcttc gtcaacaatg atcagtgtac gttcgaactg 2860441 acccatgttc tcagagttga tacggaagta agcttgtagc ggtgtttcaa ccttcacgcc 2860501 tttaggcacg tagatgaaag aaccgccgga ccaaacagct gagttaagcg ccgcaaactt 2860561 gttatcagtc ggcgggatta cttttgccca gtgctcacgg aaaatatctt cattctcttt 2860621 cagcgcgctg tcagtgtctt taaagacgat gccttgtgct tcaagatctt ctttcatgtt 2860681 gtggtataca acctcagatt cgtactgagc agaaacaccc gcaaggtatt tttgttcagc 2860741 ttcaggaata ccgagcttgt cgaatgtttg tttaatttct tcaggaactt catcccaaga 2860801 acgctctgaa cgctcagacg gttttacgta gtacgtaatt tcgtcaaagt tcagtgagtt 2860861 taaatctccg ccccattgag gcatcggcat attgtagaaa tgctcaagtg atttcaagcg 2860921 gaagtcaagc atccattgag gctcttcttt catgcgagaa atttcttcta cgatttcttt 2860981 tgtcaatccg cgctctgaac ggaaaatgga aacgtccttg tcgtgaaaac catacttgta 2861041 ttcaccaata tcaggcattt ttttagccat ccattttcac tccaatcctt ttaattgccg 2861101 ccttcttctt tcgcgactcc tttttcaagt gctttccatg acagggttgc acatttgata 2861161 cgggcaggga attttgaaac gccttgaagg gcttcaatat ccccgagatc tatagaatca 2861221 tcatactctt tcccttgcat catatccgag aaaatcttag acatggaaag ggcagtttca 2861281 atatctttcc ctttaatcgc ctgagtcatc atcgaagcgg atgccattga aatggaacag 2861341 ccttcccctt caaacttcgc atcttccacg atgtctccgt caagcttcat tgtcagtctg 2861401 atgcggtcgc cgcatgtcgg attgttcata tccacgacaa tgctgtcatt taaaacccct 2861461 ttatttcgcg ggtttttgta atgatccata atcacctgtc tgtacaatgt atctaagttt 2861521 gcattaaaag acatttgtaa aatactcctt tgtcttttga agagcttcca caagcttatc 2861581 aatctcttcc tctgtattat acagataaaa gcttgctctt gcagtagcag ttacatccag 2861641 ccatttcatc agcggctgcg cacaatggtg gccggctctg actgcgattc cctccgcatc 2861701 aagcacagtc gccacatcgt gcggatgaac atcatcaagg ttaaatgtga caagcccggc 2861761 acgctcttcc ggcccgtaaa ccgttacgcc gtcaagctgg cggaagcgtt caagcgcata 2861821 agctgcaagc ttgtgctcat ggcgggaaat ctcatcaaga ccgatttctt cgagaaaatc 2861881 aatggcggca ccgaggccga ttgctcctgc aataatcggc gtacccgctt cgaatttcca 2861941 cggaagctct ttccaagttg attcataaag cccgacaaag tcgatcattt caccgccgaa 2862001 ttcggcaggc tccatgtttt ccagcagggc tttctttccg tacagcacac caacaccggt 2862061 aggtccgcac attttatggg aagaaagcgc aaagaagtcg caatcgagat cctgcacgtc 2862121 aattttcatg tgaggcgtgc tttgtgcacc gtccaccaca atgacagccc cattgtcatg 2862181 agcgattttc gccatttctt taatcgggtt gaccgtgccg agaacattag atacatgaga 2862241 caccgcaaca atttttgtgt tgcttgtgac cgtttctctg acgtcttcta aagaaatcgt 2862301 tccgtcttcc tgcaacggaa tatattttaa tgtggcgcca gttgctttta cagcctgctg 2862361 ccacggaatg atattcgcat gatgctccat gtaggtgatg accacttcat caccaggttt 2862421 caggttggcg cgcgcatagc ttaacgccac catattcagt gatgtggtcg tgccttttgt 2862481 gaaaataatc tcagccattg acttcgcgtt aataaacttg cggacttttt cacgcgctcc 2862541 ttcataacca tctgtcgctc tggttccaag tgtatggacg ccccggtgaa cattggaatt 2862601 gtattggtta taatacttat ccagtgtttc aatgacagca cgcggcttct gggaagtcgc 2862661 cgcgctgtcg agataaacga gatcatgtcc gttcacttgc tgatgaagga tcgggaactg 2862721 ttcacgaata tctgtgatat tcattacttc actttccttt cgataacaga aactaattgt 2862781 ttcttaacgc cttcaatcgg aagttcattt actaccggtg caaggaatcc gtaaatgact 2862841 aagcgttctg cttcttcttt cggaattccg cggctcatca ggtagtaaag ctgaataggg 2862901 tccacacggc cgacagatgc cgcatgtcct gcagttacat cgtcttcgtc aattaaaaga 2862961 atagggtttg cgtctccgcg tgctttttcg ctaagcatca gcacgcgtga ttcttgctcc 2863021 gcattcgctt tagaagcgcc atgttcgatt ttgccgattc cgttaaagat agaagaagcg 2863081 gaatccttca tcacaccgtg cttcaagata tagccttcag aagctttacc gaaatggatg 2863141 atttgtgttg tgaagttttc tgtttgctct cctcttccga caacaaccgt tttcgtatcg 2863201 ccgtatgtgc cgtcaccgta aaggtttgtt gtgttttcgg aaatcgtgtc gccatcgttc 2863261 atcaggccga gagcccactc gattttgctg tcgcgtccgc gcgcagcacc gcggcggttc 2863321 acataagttg tcacaccgct tgacagatta tccaccgcac cgtatgtcac gctggcatta 2863381 tcacctgtga tgacctcact gataatattg aagacagcgt ctttcgggtt tacagtgctg 2863441 atgtagtttt ctacatatgt tacagagctg tggtcttcag ccacaatcag cacgtggttg 2863501 aatagagctg tatcattgct ttcgtggaca taaacagcct gaaccggcgt ctccacctga 2863561 acatttttcg gaacataaag gaatgctcct ccgttaacaa gagccgcgtg aagtgcagtt 2863621 aacttatgtt cgtcaacctt cacgccgtcc ttcataaagt atttctccac caagtcgctg 2863681 tgctcgcgtg cagcagtcag aatatcagtg aagatgacgc ctttgtcttt caattcttga 2863741 gaaagagaaa gatgtgccgg cgtctggtca cgctgtacgt ataatgtttt atcttcgttt 2863801 tcaatgtcga tcagcgcttt tacttcatca gtcaaatctt ctaatgaaga aagcggttcg 2863861 ttatccactg tatgcttcgc gaaattcgtg aagttccagt ttgtgatttt tgttttgtca 2863921 ggtttcggca tcggcagatc ctcagcttgt tcaagagcct gtaagcgcag gttcttcagc 2863981 caggcaggtt cttggtgctt ttcggaaaag cttttgagat actcctgatc tacggatagt 2864041 tttgtaccta gtgtcatatt aatcccccta acgcttacgc ttcttggcca acagtttcgt 2864101 cttcaatgcc aagttcttgt ttgatccagt cataaccttc tgcttcaaga cgctgtgcaa 2864161 gctctgcacc gccggatttt acaacgcggc cttgcatcat aacgtgaaca acatccggag 2864221 tgatgtagtt taacaggcgc tgatagtgag tgatcatcag gcagccgaag ttttcgctgc 2864281 gcattttgtt gatccctttt gatacaactt tcaaagcgtc aatatcaagg cctgagtcaa 2864341 tttcatcaag gatggcgatt ttcggttcaa tcatcattaa ttgaaggatt tcgttgcgtt 2864401 ttttctcccc gcctgagaag ccttcgttaa gatagcgctg agccatttca gggtccattt 2864461 caaggaactc catgttttcg tccattttgc ggatgaattt catgagagaa atttcatcgc 2864521 cttcttctct gcgcgcgttg attgctgagc gaaggaagtc ggcatttgtc acaccgctga 2864581 tttcacttgg gtactgcatt gcaaggaata agcctgcctg cgcacgctcg tccacttcca 2864641 tctccagtac atctttgccg tcaagcgtga tgctgccttt tgttacttca tatttaggat 2864701 gccccataat agcagctgat aaagtggatt taccagttcc gttcgggccc attactgcgt 2864761 ggaattctcc accttttatt tcaaggttta caccctttaa gatctctttc ccttcgattt 2864821 caacgtgaag atctttgatc gttaatgttg aagcagccat atctatacct ccaaaaatat 2864881 ataatcatta ttctcatttt attctcattc taattttata acaaatgaaa agtaaataca 2864941 actttttatc gtgccttgca cattcctcaa gtttaacaaa gatcagcact ttattaaagc 2865001 gattgaaaaa gaaaaagagt ggattcccac ccttttttaa aagattgatt ttctcaataa 2865061 gctcccgcag aaatccgctt gcttttttca taatcaagct ctctctgccg ctctactttc 2865121 attcttgttt ccagccggcg tccatattcc tcgtatccaa ttccgtgtga cagctgcatc 2865181 gctttttcca tttctgacgt ataatcgagg ttcagtctgt cctggctgct gcaaataatg 2865241 aatcaatccc ttcatatatt tgctttttat tgtaccagtg ctgcgttgga tgccgcaaaa 2865301 acgatttggc gtgaaatagc ggcagatgag acgaaagcat cctttcagaa caaatgagaa 2865361 tggtttttcg gaatattcct tctcttaatg cgtggtgttt ccgaattcct caatgcactg 2865421 ttgaacgact gtcacgcctt ggctgaaagc tgcgccgcct ccaaatgccg ctgccacact 2865481 gacggcttcg agaatgtttt cttctgacgc tccctgatca agacagcctt ttgtatgata 2865541 gatcatgcaa tattcgtcct gagcattgat ggcaattccg agggcgatca gctgtttttc 2865601 tctttcagtc agagaattcc cggcaaagca ctgttcagta aattcgttaa attttcttcc 2865661 catcagcggc atcttttgtt caaatgtgcc taaaccatgt ttatattgtt ttaacgcgtc 2865721 ctgcatgctt cctctgtctt gattcaaaga aaatccctcc atctgtttaa cattcctttt 2865781 tattatgaac agcttttagg aaaatacgcg aaaaaaaccc cggaattctc atccggggtt 2865841 tcagtcttat tcagatacag gaagcacagc tccgtcgtat tttttctcga tgaagtcttt 2865901 gatcttttta gagtgaagaa cttccatcag cgctttgatt tttgcagaat cttcttcgcc 2865961 ttttcttact gcgatgatgt tagcgtatgg gttgtttttc gttgattcta cttcaattgc 2866021 gtctttttta ggatttaatt tattttggat cgcatagttt acattgatga agaccgcgtc 2866081 tccttctttg ttttcatatg cttttgccgt taattcaggc gctacttttt tgaattcaag 2866141 gtttttcggg tttttcttaa tgtctttcaa tgttgcgtca actgtttcca ctttagaatc 2866201 aagagtgatt aatccagcgt tttcaagcat tgcaagcata cggccttgtt cagcaacgtt 2866261 gtttgtcaga atgattgtcg caccgtctgg aaggtctttc agtgatttgt atgttttaga 2866321 gtaaataccg aatggctcta agtgaacagc gccggcattc acaagtttgt aatctgtgtt 2866381 ttctttcatt tcttgctcaa ggtaaggaat gtgctggaag tagttcgcgt ccacttcttt 2866441 atcagctaaa gctttattgt acattttgta atcactaagc actttcactt tcagcgtata 2866501 gcctttttct ttcagcaatg gttcagcttc ttttaaaatt tccgcatgcg gtgtttttgt 2866561 tgccgcaacg acaatttctt tcttgccgga ttcagcgccg ttattcgaac cgcaggcagc 2866621 cataactcct gcaaatacaa gcagtaatgc acccaaaaat agctttttca atgtaaatcc 2866681 tcccttatcg tttgtctata atatttgtta ttagatcacc gatgatttga ataataaaca 2866741 cgatgattaa aataaacaca gtagcaacga aggtaacatc agcgttatta gactgatatc 2866801 cttctacgta cgcaaggttt ccaaggcctc ctgaaccaat ggctccggca attgccgttg 2866861 aaccgattaa agcgatggct gtaaccgtaa tgccagaaat aagagcaggc attgattccg 2866921 gaatcagcac tttgaaaata atcgtagacg ttttcgcgcc cattgattta gctgcttcaa 2866981 tcacaccttt atccacctca cgcagcgcga tttcaacaag gcgcgcgtaa aatggtgccg 2867041 agccgattac cagcgccggc aatgcggcgt ttggccctaa gatcgtgccg actaaaaatt 2867101 tcgtaaaacc taatagtaaa ataattaaaa taaggaacgg aatcgatctg aatatgttaa 2867161 caacggctgc aatcactgag ttgaccgctt tattctgcca gaggcttcct ttgctcgtca 2867221 gaaagagcag caagccgagg atgaccccga tgacaaaagc aaacagtaaa gaaatcagcg 2867281 tcatataaag tgtttcatat gtcgcgttcc ataattcagt taaatcaacg ttcgggaagt 2867341 atttttcaaa cattcgtgat cacctctgct ttcacctgtt tgtcattaat gaatcggatc 2867401 acgttttgca cttcttcctc gtccccgtca atgtggatga acagtgaacc gtaagcccca 2867461 tccttcgtct gcgaaatttt cccttgcaga atattgacgc tgacattgaa gtttctgatc 2867521 atctctgtaa tcagaggctg ttcagctgac tcaccgacaa atgtgagctg aaccattttt 2867581 cctgatgctg tatcatcaag aaggtgctga agcgtctctt tcgtttcttc cggctctgtc 2867641 acctgttgaa caaatcgttt tgtcatttgt tcctttggat ttttgaagac atcgagaacc 2867701 tcgccttctt cgaccacctt gccgttttcc atgacggcga ctctgttgca gattttgcgt 2867761 atgacatgca tttcgtgcgt aatcagcaca atcgtcaaac cgagtctttc attaatatcg 2867821 gacaatagat ccagaattga atctgtcgtt tgcggatcta atgctgatgt cgcttcgtca 2867881 caaagaagaa ccttcggatt gtttgcaagc gctctggcaa ttccgacacg ctgcttctga 2867941 ccgccgctca gctgggacgg ataagatttt tcttttcctt ctaaacctac cagtttaatc 2868001 agttcattgg cgcgcttgat ccgctcgctc tttttcaccc cggcaatttc taaaggaaac 2868061 atgatattat ctctgacagt ccgcgaccaa agcaaattga aatgctggaa aatcatactg 2868121 atctcatggc gtgcttttct taaaccgcgt ccatttactt cattaatctt ggttcccgcc 2868181 acttccacgg ttcctgaggt tggtttctca aggccgttca gcagacggat taaggaactc 2868241 ttaccagctc cgctatatcc tataattcca aaaatctcac cttttttaat ggaaagcgag 2868301 acgttttgga cagcattgac atctccatgt ttcgacttgt aaacttttga aacatcctga 2868361 agattgatca aagcaatcac ctgccttaac actattctaa gaaatcttcc ggttttttct 2868421 gcaaaagaaa agcctttctg cacacttgag cagaaaggct tatataaaat gcctttctct 2868481 catctttcaa agctgaacgc ttcgtgtgaa ttggcaccat ttcaacagtg ttgatggttg 2868541 ccgggcttca tagggcactt ccctccacct ctcttgataa gagaaatata tagtcttttt 2868601 cgtccggaaa ttcttaatgt agaatagcac ggcgaatgat taaatgtcaa taaaataaat 2868661 gatgtcaact tttactatta taataattta ttatttttta attttttaaa atcctctgaa 2868721 aaaatccatt tgtcagccag agaatggctt ccagctttaa cagggccctg aatgacccct 2868781 ttactttgag gcttccgctc tgaataaggt gctgaaggga aatgtctccg tgcaataaat 2868841 caataatttc cgtttggttt ccgtaaaagg tcaggttgga cgtttggggc ggagaaactt 2868901 ttttcatttc tccctgttcg tttattgaga cggttaaggc ttctgcttct ccttggaagg 2868961 taatgagcaa tgttgaggca ttcaaaaggg gttttaaaaa cagatgctga tactcatctt 2869021 ctaaaacttc cgctttctcc atatgtacaa cctcctattt gttggtcata catacacatt 2869081 tctctctttg tcgcaagaac ccctttataa aacgaacgac aatttcattg gatatgctga 2869141 gaaatatgtc ataaatggga tgcggaagat gatttttgtt tgatcagctc atataaataa 2869201 gaaacggaat gaaatgcata tcctctttcg accatctttc cgcctttaaa cagcagaaaa 2869261 caagggacgc tttcaatttg atacgctttt gcgaatgtcg gagagtaatt gacattgttt 2869321 tgatagaagg cgacatccgg cagcatttct ttcaccactg tcagcatttt gcttgcaagc 2869381 tggcaggtgc cgcaaaacgg agtatataaa tatagaaggt acacatcatc ttcaatgtga 2869441 tcaagttcgt gttcttggag ttctttcatg ctatacacct cgggactttc tttcaagaaa 2869501 aatagtatgg acattcagat tcgcacgcag caatacagaa gcgatatggt gcctgggcgc 2869561 agccgctact tccttatagg ctctgtcgac atggagatgg caggcttcat taaattcacg 2869621 cttcagctgt tttctcaatt tctcacctga ttcatcagca tcaactaata tatagacgtc 2869681 tttatcataa agctcgtcag ccaattcctc gagcctcagc tggctgattg ttccgtttgt 2869741 gcagataatg cgcatcggtt cattcaggac gctttcgatt ttctctttat ctgatttccc 2869801 ctcgacaatc ataacctttt ccagctcatc catcttcatc ttgttcacct gccgcgtcaa 2869861 atttgaaatg ttcagattgt aaaagaaggc agtgaaattc accgccaaca ttaacaccag 2869921 ccgttttcgt agtcacaatc tacatatttt gcgtcgtctc cagagaccac atcggctgtc 2869981 ttataaaatt tctcattttc aaaggaataa ccggacttaa gctcatattc attcatgctt 2870041 gtcatttggc cgatcatctc attatcatga tataacgaga gccggccatt ttgaaagcgg 2870101 cctgtcacgt cattggtgac atcgagcttt tgtttgtcga aagccatatt ggacacctcc 2870161 cataacgtta gcgtgtccaa ttgcttttac ggctatcctg ttttagtctt cttgtgtcat 2870221 ctcttcgtat tgctctgctg tcatcagttt ttcaatttca gaagcgtcag atggctcaac 2870281 gacgatcatc catgcttttt cgtacggaga ttcgttgacg aattccggac tgtcatcaag 2870341 atcttcgttt acttccacaa ccgttccgtt aatcggtgca taaagctcag ataccgtttt 2870401 aacggattca acactgccga atggctcgtc cgctttgatt tcagcgccca cttcaggaag 2870461 ttcgacaaac acgatgtcgc ctagttcgga ctgggcaaaa tgcgtaattc cgattctggc 2870521 tttttctcct tcaactttta cccactcgtg ttctcctgag taacgcaaat cttttggtat 2870581 gctcaattga atccctccat tttttacagc actacaataa gaagatacca cacttttcaa 2870641 aaaaaattta cattaagccc agttttcttc aaattggtct tctttaaatc cgacagtcac 2870701 tttttcgccg tctgttgtaa gcgggcgttt aattagcata ccatctgaag ccagcagttc 2870761 gagctgttcg tcctctgaca tatgatacag cttttccttg agattgagct cgcggtattt 2870821 catgccgctc gtgttgaaaa atttcttgag atccagcccg cttttttcat aaagcgcttt 2870881 taattcttct ttgcttggcg gctgctcagc aatatgtatt tcgtttattt ctttcccatg 2870941 ctcttcaagc cacttctttg ctttgcggca cgttccgcat ttagggtacc agtaaaaagt 2871001 taacgacatc ttcttccccc tcaataaaat aatcgaggtt attttaacac agtttgtttt 2871061 aaaaacctaa aacagtgctt cttaaaaaag agctccgcgc atgcggagct catggccaat 2871121 cagacagtat atttctcagc ctcaaaaatg cctgccgccg cctcgcgttt tttctgaatc 2871181 acgtttttag gcgttacgcg tgtcagcttg cgcagagcgg aaagcatcat gcggagtgaa 2871241 tctccttctt ccattgcgat aagggattcc tttgcatgcg cttcgatttc gttaaaggcc 2871301 tcttgaacga aaatttctgt gtacagcacc ttttgcgctg ctttttcagc gccttgtgcg 2871361 gcaatggcct tttccgttct gagcacggct gattccattg cgtatacatt gctgacgata 2871421 tccgctacgt tcacgagaat ttcttgctca cgatcgatcg cttttccgta tttttgcgcg 2871481 gctaggccgg cagcaaacaa cgcaattttt ttggcttgct tgacgatata tttctcctgc 2871541 tctaagacgc cgcttccagg ctcttcaggc ataagcatca tgagttcttc ctgcagcgac 2871601 tgcgcttttt cgaataaagg cagctcgcct ttaagcgctt ttttcaggaa ggtgcttggc 2871661 acgattaacc ggttgatttc gtttgtgcct tcaaaaatcc gattgatcct tgaatcccta 2871721 taggcccttt ctacttcgta ttcctgcata aagccgtagc ctccatgaat ctgcacgcct 2871781 tcatcaacga tataatcaag cgtttcagag ccgaatacct tattcagaga gcattcgatg 2871841 gcgtattccg caatcgattt ggcgatttgc cggccgtcct tgagatcttc ggccgtgaac 2871901 tggctcatat tgtcttcaaa cagcccgacg gttctgtata cagagctttc catcgcatac 2871961 agccttgagg ccattgtccc gattttttcc tgtgtcaatg aaaaaccagc aatcggcgtt 2872021 ttaaattggc ggcgctgatt tgcgtatgcc gcagacagct cgatgacgcg tttagatgcg 2872081 ccgattgtgc caaccgccag tttgtaacgg ccgatgttta aaatattaaa ggcgatgaca 2872141 tgccctttgc cgatttctcc gagcaggttt tcctttggca cttcagcttg atccagaatg 2872201 agggttcttg tcgatgatcc cttgattccc attttctttt cttccggtcc cgtggagaca 2872261 cccgggaact ctttttctac aataaaggct gaaaacttgt cgccgtctac cttagcgtaa 2872321 actacaaata catcggcaaa agcagagttg gtaatccact gtttttcccc tgttaataca 2872381 taatgggttc ctgcttcatt cagcacagct gttgtttttg ctccaagtgc atcagaccca 2872441 gagccaggct cagtcagagc ataagcggcg atcttttcgc ctgaagcgag tccaggcaaa 2872501 tattttttct tttgttcttc tgacccgaaa aagacgatcg gcaaggaacc gataccgaca 2872561 tgcgcgccat aagaaagaga aaagcttccc gcacgcgaaa atttctcagt gatgagtgcc 2872621 gagctgattt tatcaaggcc gagcccgccg tattcttccg gcacatcggc gccaagcagc 2872681 cctagttcgc ccgctttctt caacagtctg acagaatgct cgaattgatg gttttcgata 2872741 tcatctatat gagggagaac atcttgctcg atgtaatcct ctgttgtttt cgcaatcatt 2872801 ttatgctcgt cagtgaaatc ctccggtgta tacatttgat cgtatgtgac atcctcgatt 2872861 aaaaatccgc cgcctttttg tacgtcagcc gctttttttg ccatttgttt ttcccccttt 2872921 agcataattc aaatacaccg gccgctccca ttccgccgcc gatacacatg gtcacgactc 2872981 caaattgctc gtttctccgt ttcatttcat ggatgagtga gagtgtaagc tttgtgcccg 2873041 tacagccaag cgggtgtcca agcgcgattg cgcccccgtt gacattcact ttttcttcat 2873101 caattcccaa ttccctgatt acttgaatgg cctgtgaggc aaaagcttca ttcagttcaa 2873161 acaagccgat gtcctgcagc tgaagtccgg caagcttcaa agcgcgcgga atcgcttcca 2873221 ccggtccgat tcccatcact tccggcggca cgccgcctac cgcaaaggag cggaatttca 2873281 caagcggcgc caggccaaga gcatcggctt tttcccggtc catcagcatg acagccgccg 2873341 ctccgtcact cgtttgtgag gaattgcccg cagtcaccgt cccgtcaacg gaaaaggccg 2873401 ggcgcaatgt cgataagatg tctgcagtcg tttgcgggcg aacaccttca tcctgagaaa 2873461 acacaaactg tttttccata ggcttatggt cttctccgat ttctgtcacc gtcacttcga 2873521 cgggtacaat ttcatcttta aattttcctt ctgcaagggc tttagcggcg ttttgatggc 2873581 tgcgaacggc aaacgcgtct tgatcctcac gggagacgcc gtattttttc gcgacttgct 2873641 cggctgtgtg ccccatgctc atataatatt ccggtgcctt ttctgccaaa gcaaggttcg 2873701 gacgggtaac atgccccatc atcggaactt gcgacatgga ttctgctccg ccggcgatcg 2873761 ctgtatcgta ggcgcccagc ataatttttt ctgctgcata cgcaatagac tgaaggcctg 2873821 aagagcaata gcggttaact gtaatcgccg gaaccgtgta cggcaggccc gcgagcgcac 2873881 cgatatttct cgccatatta agcccctgct ccgcttcagg tgttgcacag ccgataatca 2873941 agtcatcaat attgccttcg tagccgcctg cccgtttcag cgtttctttt acacaaatcg 2874001 ctcccaaatc atccgggcga acggtggcca acgatccttt ttttgctttt ccaaccggtg 2874061 ttcttgcacc tgacacaatg actgcctctt tcataagctc cctcctaatt ccgtaaaggt 2874121 ttacctttca caagcatatg ctgcattctc gcttgagatt ttgcctctcc tgacaaactc 2874181 aaaaacgctt ctctttcgat ctccaataaa tactcttcat caacctctgt accaaacggc 2874241 acttttccgc ccgcaatgac ataagcgagt tttttcgcga tcttaaaatc atgctcagat 2874301 atatagccgg acagcttcat ctgctcagcg ccaagcaaga gtgccgcata accggtttct 2874361 cccggcacct tgaccttttc ttttacaggc ggccgccagc cggtatcgta taaagatgcg 2874421 gccagctgct tcgcatcgta taacaggtgg tcttgattca cgctgatctg atccgtttct 2874481 tttaagatgt tcatctcacg agcctcttga gcggaagcgg acactttcgc catcgcgatt 2874541 gtttcaaatg ttttcattgc cgcattcatc ggatcatggc cgcggcgaag atggttgatg 2874601 tacagctctt tgttacctcc tccgccaggg atgaggccga caccggattc cacaagtccc 2874661 atataggctt cgcttgccgc ttgaatgcgc gccgccggca ggcatgcttc cgttcctccg 2874721 ccgagcgtca tgccaaatgg cgcggcgacg accggtttcg cactgtattt gatcttcatc 2874781 atcgtctcct gaaaacggcg gatcacaaaa tcaacttcca aaaagttgtc atcttggact 2874841 tccattaaga tcatggcgag attcgcgccg acgcagaaat ttttcccttg attgccgatg 2874901 acaagcccct tgtaattccg ttctgtttcc tctaatcctt tgtggatcat ttgaatgata 2874961 tcgaggccga tcgcattgct tttcgaatga aattcaagaa gggccacatc atctccaagg 2875021 tcaattaagc ttgctccgct gtttttcgca atcacgcctt ttgtttcttt aagtgcttgt 2875081 aaatgaattc gttttttgtt ttctttcacg gctctgtatt cgccgcggtc ataataaaat 2875141 accgttccgt tctctttgat gtagaaggtt tcatttcctt tgtccagcat ctcttttatc 2875201 cagccaggca tatctgctcc aagctgctca agcttttccg ctgactgctt gaggccgatg 2875261 gcgtcccaca tctcaaaagg tcccagttcc cagccgaatc cccacttcat ggcttggtca 2875321 atcgcatgaa tatcatcggc aatctcgcca agcagctcgg ctgagtaaag cagggtttga 2875381 gaagtgatat tccacagcaa acggccggcc ctgtcatccg aataaataag cgctttcatt 2875441 ttggcttttg tcccttttgc ctgttttgcc gcttcaagtg ccggtgattt catttttgtc 2875501 cgctcgccgt aagtaagcgt cactgggtca agctcataaa tcgtttttcc ttctttttta 2875561 taaaagcctt ggccggcctt gcttccgatc cacccttttt ccagcatatc gttcatgaag 2875621 cttggaatgc gaaacacttc tttttcatcg ccatcagctt tgtcatacac atttcgggca 2875681 acgtgggcga atgtatcgag gccgaccaca tcaagcgttc taaaggtggc gcttttcggc 2875741 ctgccgatca gcggtcctgt gatcgaatca acctccccga cctgataacc gcctttcagc 2875801 atttcttgga ctgtcacgag aagcccgtaa gtcccgatgc ggtttgcgat aaagttcggt 2875861 gtgtcctttg ctgtaacaac gcctttcccg aggacatttt ctccgaaagc tgtcataaac 2875921 tttaaaatat caggatccgt ttccttaatc ggaatgatct ctagcagctt taaatatcgt 2875981 gcgggattaa aaaaatgcgt tccaagaaaa tgggctttaa aatcatccga ccggccttca 2876041 gccatttcct gcactgatat gccggatgtg ttgcttgaga cgatgcttcc agtctttcga 2876101 tgttcatcca caagagcgaa aattttcttt ttgacttcaa ggttttcgac aacgacctca 2876161 ataatccaat ctgcttcttt cagtttttct gcatcatcct ccagattgcc aggtgtaata 2876221 taggaggtat ttttcgctga tgtgagggga gcgggctttt gtttcagcag ttttttcatc 2876281 gcctgccggc tcagcctgct gcgcacctcc gaactgtcct tcgtcagccc ctttttttcc 2876341 tcttcctttg tcaaatcgtt cggcacaata tctagcagca ggacaggaat tccgatgtta 2876401 gccaaatgcg ccgctatccc ggaacccatt acccccgatc ctaaaacggc tgccttccga 2876461 atgtgtttgt gcatgagata tcccccttga acattgaatg aatagtcatt cattttttga 2876521 ctaaaaaaaa tgaaacccgt ttcttctttc atcttaaaag atttccggtt cgacttcaat 2876581 agctaatttg ttattttttt gtatgaagcc tataaaagtc gggcaactta agcccggagg 2876641 tgaagggaat ggtacgagag aaaaaaaatc cgtcttcagc ggcagtcagc gcggcgagcg 2876701 taaagggaga tgccggtccg actcagcatt acggcggcgg aaaacggaca agtcaaaatc 2876761 agcagtataa aaaacataac atgggacaat cataatgcag ctgcttccca cggctgcttt 2876821 cactttttca aaattccttt taacacaaac gctgcattgg caggccgttc ggcaattctt 2876881 ctcataaagt agctgaacca gtccgttcca tatgggacat acacacgcat tctgtagcct 2876941 tccttggcga gttccttctg acgctccggc ctgatgccgt atagcatttg aaactcaaat 2877001 tgcgatgcgg ggatttgatg ttcggcgacg agctgtttcg taaatgcaat gatgtcatcg 2877061 tcatgtgtgg cgacagccgt gtagttcccg cttaacaact gcagctttat taagctctga 2877121 aaatgaaggt ccgtgcctct tttgtcggga aacgctacag ccgcagattc tttataagcg 2877181 ccttttacaa gtctgagatt cggctttaag tcccgcatct ttctgatatc ttctgccgcc 2877241 cggtacaaat acgcctgaat gaccgtgccg agcttctcaa attcctgttt gcattgcctg 2877301 taaatagaaa gtgtctgttc ataatgagaa tagtcttcca tatcaatggt cacagcaaca 2877361 tcatattgct tcgcaacgga aagaatggcg cgcaaatgag taagagcaag ttcttctgaa 2877421 agatcgagcc cgattgaggt cagcttaagt gaaagctctg aattcaattg atgttcggca 2877481 atggcttgaa tggctttctt gcattcctct gcgacttggt ttgcttcttt ttccgaagct 2877541 gcatactcgc ctaaataatc aattgttgca cacaaaccgg atctgtttag ccttttgacg 2877601 gtcttaaccg ccgattcaat cgtatcccct gcgacaaacc ttcgtgctcc aagccgcgtt 2877661 ccgtatgctt ttgcgaactt ggtaagtgtt ttattttgag ataagaataa aaacacatgt 2877721 ctcaacatcc gactccctcc cgccgtcatc ttcaaaacac ctgtatataa ctcccagtct 2877781 gaaggaaact ataaaatgaa cagaaaccaa aggaggatca caatggataa tcagcagcaa 2877841 tctcaaatgc cgccttccgt tatttcgaca aaggatcatt tgtatctcaa tgacatgctg 2877901 aactggaatt tgctcgcgat gaaaaaagcg catttcatgg cgcagcagtg ccaggatcaa 2877961 acgttaaagc aagaactcga ccgcgtcgga cacatgcatc atgatcacta tcaaagaata 2878021 ttaaagcacc tgcagccagg ccagcagcag tccggctaca tccaataagg aggcgccaga 2878081 atgaatcagc aaaatcaaaa aatcagcaac ccgcagacac ctgtaccgac aacatcggaa 2878141 atgaatgaca gagatttcgt caacgaattg ctgacaaccg aaaaatacat gacaacagct 2878201 tattgcactg ccttgcacga attcagccac gagtctcttt atcaggatat tcaatccatt 2878261 tttgatgagt cacaaaaagc gcaaagaaaa ctatatgatc tcatgttcca atatggatgg 2878321 tattctgttg aagcggagga ttcacaaaag ctgcagcagt cctatcaaaa attccagcag 2878381 accattcagc agcagtctcc ttatcagcaa taacaacatt agtaaaaagg atacgatgtt 2878441 ctttcgggca tctatccttt ttttgtgtaa aatcagttga cttttcattt acgcttattt 2878501 atatttaata agcattaact attttgtcat taaaatatat atacagtgta tgtaacagag 2878561 gggaaatgaa tatgaagagt gcggatcagt taatgtccga tattcaatta tcgcttcagg 2878621 cgctctttca aaagatacag cctgaaatgc tggaaagcat ggagaaacaa ggtgtcaccc 2878681 cagcgcagct gtttgtgctg gccagcctaa agaaacacgg cagcctcaaa gtttctgaaa 2878741 ttgccgagcg tatggaggtg aagccaagcg cggtgacgct gatggcagat cgccttgaac 2878801 aaaaaaatct tatcgccaga acacacaaca caaaagacag gcgagtgatt gatctcagtc 2878861 ttactgacga aggagacata aagttcgagg aggttttggc gggcagaaaa gccataatgg 2878921 cgcgctatct ttcctttttg acggaggagg aaatgctgca ggcggcgcat attacagcaa 2878981 aactcgcaca agcagcagaa acggatgaaa agcaaaacat gaaaagagga aacggatgaa 2879041 aatgagtaaa gaaggcaaac aatcaaaacg aacgttatta ataacaggct taattattgc 2879101 catgtttttt tcagcccttg acggtaccat tgtcggaacg gccatgccga aaattgtcgg 2879161 tgatctgggc ggtttgagca tgatgacctg gctgacaact gcatatttgt taacatcaac 2879221 aaccattgtt ccaattgccg gtaaactggc tgatttattg ggacgccgca ttgtctatgt 2879281 atcaggtttg attattttta tggccgcttc tgctttgtgc ggaatggcca acaacatgac 2879341 ggaattgatt atcttccgtg gactgcaggg catcggcgga ggcatcatga tgccgatggc 2879401 gatgattgtc atcggtgact tgttcacagg aaaacagcgt gctaaattcc aaggtgtctt 2879461 tggcgcaatt tacgggctgg cttcagtgat tgggccgcaa atcggcggct ggattgtaga 2879521 ctcgttaaac tggaaatggg ttttctatat taacctgcca gtcggaatta ttgcggttat 2879581 ttttattgcc aggggattac agggacgcca gcagactggt ccgatcaact tcgatatcgc 2879641 tggtattttc acaatgattg tcggtgtggt cagcctcctg ctcgccttaa gctttggcgg 2879701 aaaagattat gcatgggatt catggcagat tcttgggttg ttcgctctcg cactgatcgg 2879761 cattgtcagc tttatcatcg tagaatcaaa agcaaaagag ccaatcctgc caatgtattt 2879821 atttaaaaac agaacattta catttctaaa cttgatcggc ttctttatga gtatcggtat 2879881 gtttggcgcc attacgtttg ttcctttctt tatgcaggga attgtcggtg taagtgcgtc 2879941 tgaatcgggt acaattatga caccgatgat gatttctatg attatcacaa gtatcatcgg 2880001 cggacagctt gtttataaaa ttgggattaa accgcaaatc attacaggca tgctggttat 2880061 ggccggcgga ttcctgctgt taacgacatt ggatctcgac acgagcaagc ttgtcgctac 2880121 atcttttatg gcgattattg gtctgggaat gggtcttgtt atgccgattc tgacattggc 2880181 tttacaggaa agcttttcga aggaggagct tggagttgtc acttcatcca gccaattctt 2880241 ccgttctatc ggcggaacat tcggcattac catgctggga gccgtaatga atgcgagatc 2880301 aggaaatcta ttaacagata aattggttcc atatttagac tctcttccgg cacaggcaag 2880361 ctcgtttgcc gcccagctaa agggtatgat tgatacaaat ccgcaagggc tgctgcaatc 2880421 actgttcagt ccggacgcgg tcaaacaaat ccctgcggct ttctcatccc atattgtgcc 2880481 gattttaaaa acatcgttga tggattcgct ccacagcgtg ttttatacgg gcctgatctt 2880541 tatcgcagtc ggagccgtat tcaccttgtt cttaaaacct atcaagctat caaataagaa 2880601 agcggaagac caacaagaaa aagagaaggc ggcaaaagcc gttgaatcac cttcccatta 2880661 atagagcacc ccgcgggtat caatccgcgg ggttttttat tcaatcatct gggctcttcc 2880721 atttccgaaa gaccaatcct catcctgatt tccggccagc atgataaaca catcttcttt 2880781 tcttacacca agctcggaat gaatccggct cgcgattgag cggtaaagtg cttttttctg 2880841 ttcagttgtt cttgactgtt tcagtgtaaa atgaatgtat atcagttcat cagtacgctc 2880901 gacttggaga taaaatggat cataaaaaaa ttcgcttttt tcatattgtc tgatgacttg 2880961 gaaatagtca tcttccggca cattgatttc ttcaatcatc gattggtgga tagtcctgct 2881021 cagtttttga agccacactt cgcttcttcc cgaccgtaaa tgaatctgta caaatggcat 2881081 ctccccgcat ccctttcttt acagcgtctg tccgctgtca attgtgataa tttggcctgt 2881141 gagtgattcc tgttcaatta gtgaacaaat caatttggca acatcatctg gttcagcaat 2881201 acactgcagc agcaaagagc cgatcatgct tttcattttt tcttcccgtc cggcccacca 2881261 tctcgttgcc acagctcctg gtgctacacc gctcactctg atttcaggcg ctaaggcgtg 2881321 ggccaatgat ttcgttaaac cgtgcaccgc tgattttgat actgcgtaag gcattgatga 2881381 gccggcacca gttatccctg cgatgctgcc gacgtttacg atcgccccgt ccttgctttt 2881441 cttcatgaac ggaaccactg cccgcgcgca gaaaaacatc cctttcacat tgacggcata 2881501 cagctcatcc tagacgtctt ctgtcgcagc ctcaagatca tccattggaa tatgccgtgt 2881561 aatgctggca ttgttgacta aaatatcaac cgtgccgtgt gtgttcacga ttgcttgaat 2881621 catatcctgc acgtcgctgt ttttggatac atctgcttgg atggcgaagg cttgcccgcc 2881681 agctttttga atcatttcca ctgtttcctc cgcttctgat tgcgagcgtg aataattcac 2881741 cgccacaatc gccccacgct ttgccaattc catactggct gcttttccga ttcctgtgcc 2881801 gccccccgtt acgagagcta ttttgttcaa gacattcatt gccgccactc cttgctgttg 2881861 actaaagtat atttctgatt ccattgtaat ccagctttga tgttacgtat aatgattgtt 2881921 aaagatacta gatatcactc agattgatag taaacgaacg gaggagttca aaatggaaag 2881981 cggagattta cgtgtgtttc aaatggtagc tcgtgaaggg accattacga aagcagccct 2882041 gcagcttggc tatgtacaat cgaatgtcac ggccagaatt caacaattgg aagctgagct 2882101 gggtaccaca ctgtttttgc gccataatcg gggcatgaca ctttctgcaa gcggaaaatt 2882161 gctgctggac tacgcaaata aaattatagg ccttcttgat gaagcgtcta aagcgctctc 2882221 atcctccgca gaaccaagcg ggccgcttat gatcggctgc actcagacaa ccgccgcggt 2882281 aaggcttcca aagcttctgg catcttatta tgaagaacat ccaaacgtcc agctgtcttt 2882341 aacaacagga catacgcaat ttctccttga taaagttctt cgttatgaat tggatggcgc 2882401 gtttatcgga tgcgaatgcc atcatcctga gctcgaatcc tatcctgcgt ttgaggaaga 2882461 accagtagtt gtttcggctg cctccgtgcc cgatgttgag gaagccatca caaagccgat 2882521 tctcgtttac agcacaggct gttcgtatcg agaaacactt gaaaaatggc tgcgttccgt 2882581 cggtgtcaca cagccggtca ttatggaatt tgggacgctt gaagcaatta tcggcggggt 2882641 tacagcaggt cttggcatct cgttgctgcc aagaacggtt gtgcagaaac atgaagcaga 2882701 aggatcaatt cgattgtacc cgctgcctga agctctcagc cagatgaaaa cagagtttat 2882761 tgttcgaaaa gattcgttta tcagcagcgc gctgagaacc tttatggatt cctttacgcc 2882821 agttaaaacg gctgaatcac aaaaaagcag tctgctataa tgaacagact gctttttggc 2882881 tattgtttgt ttcgatgcgc ttcatttaat tccttaatat gctgaatgat ctctttaatg 2882941 ccctgcttcg cgtcggggta tgtcgcattc caatgcttag cgagcggagg catgcttttg 2883001 gctatatggg tgtacaaaat ccattgcttc acttcttctt ttagctcatc gtttgtttca 2883061 ccaagcagaa gctcagtata cttctccagc aatccatcaa gctgctcctg aagtttttgt 2883121 tccattttcc atcttccttt cgaaaaaaca gcaaggagct ttctcaattg aaagctcctt 2883181 cgctgcgtta tttatccatg tgatgtgaaa gccgcttcct ggacaatgca tctgcccctg 2883241 ccatgaggaa tgcaaagagg cgttccgaag agcgggtcct gtgtaacctg acagttcata 2883301 gaaaacacat tttgcacaag atcacaagtg atgacctctt ccggacggcc ttctgcataa 2883361 atccgtttat cttttatggc cacaagatga tgcgcatagc ggcacgccaa gtttaagtca 2883421 tggagaacca taacaatcgt ccggtcttcc ttttcattca gctcaaacag caaatcaaga 2883481 atttcaattt gatgcgtcat gtctaaatac gtcgtcggct cgtcaagaag gatgatatcc 2883541 gtttcctggg caagcgtcat cgcgatccaa gcccgctggc gctgtccgcc tgacaaagaa 2883601 tcaacggcac ggtcagccat gtcctcaagc tttgttgctt taagcgctct ttcaactgct 2883661 tcctcatcct cttttgacca ctgcttcagc cagttttggt aaggatatct tccttgcttc 2883721 accagctgat gcaccgtcag cccctctgga gccgaaggac cttggggcag gattgcgagc 2883781 tcttttgcga cttccttcgt cggaagcttg gcaatcgctc ttccttccag cagcactgaa 2883841 ccgcctctcg gcttcatcag gcgcgctaat gaacgtaaaa gtgtcgattt tccgcagcca 2883901 ttgctgccaa taaatacggt aatttcacct ttgggaattg ttaaattcaa ctcatcaata 2883961 ataacggcat ccccgtatcc taagctcagc gtttctgtag aaattgcact catacccata 2884021 accgctcctt tttgctggct ttttagcagc actatgtatt gcacgttttc tatatacatg 2884081 cttttaagtc aattgtcatc aatgcaaatg attccgatat tcagccattt gatatggtca 2884141 tatatccctc attgtagcag aaaacactga ctttgaaaat cattttcaat tagttttatg 2884201 gacataattg acgtttatgg gttttttatc acaagattac ttcttgattt ctctgatgga 2884261 gccgtccttc agcttcaatt ttaaatcgat atgatcataa tgactgtcca gattaaatgc 2884321 tgccagcaca ctgtgtatca cttctgtttc agccatttgg tctgtcacgg aaagctcgct 2884381 caaaatcatt ttcatctcat ctaacgcttc ttctccttcc tgattgacac cggagagctt 2884441 atcctgtatt tccgcttttt cctgagtccc gttctttgta tagattcctt cataacggtt 2884501 atgctcacca tccccgtagc tcacacgaag cgaaaaatta ctgtagggaa cggacttcag 2884561 ctgggtgacg gctgtatttt ctccttctgc ctgatgctgg tcttcattga aacggcagcc 2884621 cgcaatcaga accactgcga gacatacagc cccggctgct ctgatcaaat gcatatgttt 2884681 cccccctgta ggattccatt tattttaggt atatccagag aatgaaatcc tcattcagag 2884741 aagaattgaa aaagccgggg catttaacgc cacggctttt tctttaagat tcggtcattt 2884801 gtaaaaaggt ttcggcgtca cgcacagcca gcttgatggc attctcccag aaatcgcgct 2884861 ttgtgatgtc agcgcccaaa tgcttcatcg ccaaatcctc cactgtcata gaagccgtat 2884921 cgcgcaatag cgccatatac ttctcttcga atgtgtcttt ttcttcaagc gccaacgcgt 2884981 aaataccaag agaaaacagg tagccgaatg tataagggaa attgtaaaac ggcaccctcg 2885041 tgatgtgaaa atgaagcttt gatgcccaaa aaagcggatg atattcttct aacgcattgc 2885101 agtatgcctc tctttgcgcc tcttccatca gctcattcaa gcggctggcc ggtaccactc 2885161 cccgctttcg ttcctcgtag aatctcgttt caaatagaaa tcttgcgtga atgttcatga 2885221 agaacgcaac gcttctttgc actttatcct ccagaagaac aagcttttct tccctcgtct 2885281 cggcctgctg gacagtcgcg tccgccacta tcatctctgc aaacgttgaa gctgtttctg 2885341 caacgttcat ggcgtaggaa cggtttaacg gcctgacgtt gagcattgct tcctgatgga 2885401 acgcgtgccc gagttcatgc gcaagggtag agacatttga ggcgcttccc gaaaatgtca 2885461 tgaaaatccg ggattccccg ctgtccggaa aactggtgca aaagccgccg actctttttc 2885521 cgctcctgtc ttccgcctca atccagccgt cccgaaacgc tttttcagtg aatgaggaca 2885581 gctttttgcc aaacgttgaa aactggctgg taatgatatt tgcggcttca tcatacgaat 2885641 agacctttcc gtcagaaccg atcggtgcct cgacatcgta ccagctgagt ttttcaaggc 2885701 cgagcatgga tgctttccgg ttcaaaaact gaacgaacgg cttcttgttt tcagtgatga 2885761 cctgccacat cgtatcaagt gtttcttttt tcatcctgtt aatttgcagc ggttccttca 2885821 ggacattctc ccagccgcgc gctttatagg tttcaagccg gaatcccgcc aaatgattca 2885881 gcgtgctgct gaaaatatct tgcttgctct cccaagcttg gcggaaacgt tcatatactg 2885941 tttttctgac agtacggtct tgatgatcca tcatattctc cgcctgaccg acagacaatt 2886001 gcttgttttc accgttttcc tcatacggga tcgtcatttt cccgacaacc atattgtata 2886061 agtcactcca agcgtgatat ccgtccaccg caaggtttcc gatcagtttt tccttaccgg 2886121 ggctaagctt ttcggcaacc ctctgtcttc tttcatttaa tatgtaagaa acatcgcgca 2886181 atcccggttt tgttaacaat tcattccaca cgtcttgatt aatgtccaca agtttatgat 2886241 ctaatgtaac gagcgacgat tgaaaatctg cggaaagccg attcatgagg cctgatgctc 2886301 tatagccttt tgatcattga tattctgggc ctggaggcaa gcaacaaaag cgccggcctg 2886361 ctgaagcttg acggatgtct gttcgaataa atcaagcaac gcggtcagcc cttcagcctc 2886421 ttcaggcgat tcaggcacct gaaacgcatc agtcctgtct tgaaatgcac gcagactttg 2886481 tgacagcttc tcaatataac ctttgaattc ttccgattgg ctcccgccct taaaaaatga 2886541 atcaagatcc catctttggc ctaccccttg cagcgccata tcacaaaacc cctttccttc 2886601 tttcgttcta ttatagaaca attctgaatt attgtataaa aatttctatt acaggcgtca 2886661 tttcgtgttc aggatagtac aatagctgta gcagtttaat aggagggtta ggatgaataa 2886721 aaaaatagcc atcgtgacag gagcgtccag cggcttcggt ctgctggcag ctgtaaagct 2886781 tgcccgatca tttttcgtga tagccacatc aagacagcct gaaaaagcgg aacagcttcg 2886841 agaattggct gcagcacaca atgtgtctga ttctattcac attacagctc tcgatgtcac 2886901 cgatgaacaa tctatagtct cattcggaaa agctgttagt gcttacgccc cgatcgattt 2886961 actcgttaac aacgccggaa cggcttatgg aggatttatc gaggatgtgc cgatggaaca 2887021 tttcagacaa caatttgaaa cgaatgtctt cggtgtgatc catgtgacaa aaaccgtgct 2887081 gccttacata agaaagcatg gcggcgcaaa gattataaac gtgagcagca tcagcggact 2887141 gacaggattc ccagcgctgt cgccatatgt ttcttccaag catgcattgg aaggtttttc 2887201 tgaaagcctg cgtatcgagc tgcttccgtt cggtatcgaa accgctttga tcgagccggg 2887261 ctcatacaag acatcgatct ggtcaacgtc attatcaaat tttatgtcgg tgcctgctga 2887321 cgattcagcc tatcatcaat actataaaaa gatcctttcc tatgttcaaa aaaacggaga 2887381 agaaagcgga gatccccaag aggttgccga cctcatttat caattggcaa caaaacagca 2887441 cataaagaat ttgcgatacc cgatcggaaa gggcatcaag ctcaccctgc tgttccgatc 2887501 gctttttcct tggtctgcgt gggagtctat cctgaagaaa aagctattca gctgatctaa 2887561 attataatta ttataattta gtattgattt ttatttagta tatgatataa ttaagtcaac 2887621 agatcacaag gaggacgtta tcttatgaaa actgaaaacg caaaaacaaa tcaaacatta 2887681 gttgagaatt cactgaacac acaattatca aactggtttc ttttatactc taagctccac 2887741 cgtttccatt ggtatgtgaa agggcctcat ttctttacat tgcacgagaa atttgaagaa 2887801 ctttatgacc atgcggctga aacagtggat accatcgctg agcgcctgct ggcgattggc 2887861 ggacagcctg ttgccacagt gaaagaatac actgagcatg catctatcac agacggcgga 2887921 aacgaaacat cagcatcaga aatggtacaa gcattggtaa acgactacaa acaaatcagc 2887981 agcgaatcta aattcgtgat cggcctggct gaagaaaatc aagacaatgc gacagcggac 2888041 ttgtttgtcg gattaattga agaagttgaa aaacaagtgt ggatgctttc ctcttattta 2888101 gggtaacaaa aaagctgaac cttaatcggg ttcagctttt tgttttttct tagcttgaac 2888161 tgctttctgt ctgcttggtc agtgttgcgt tcaacgtttt cgtttttccc tttcgcagca 2888221 cttggattgt tgttttatct ccgactttta agtctttgta aaggatctga cggatatccg 2888281 cactgctttc cacgtcttta ccgtttagtt tgacaatgac atcctcagat ttaatacctg 2888341 ctttttctgc cggcgaattt gcttgaactt cttttacata aacacctttg cccaattgat 2888401 ctccaaacag gccgagcgta ttttcctgat aggtttcagg aacttgtgac atgtcaatca 2888461 tctgcacgcc taaaaacgga cggtccacct tcccgttttg cagcagctgg tcaacaatcg 2888521 gctcgacatc attgcttggg atcgcaaatc caagtgattc cacgccgctt tcgctcacct 2888581 tcaagctgtt gatgccgatg acctggccgc ttgcattgat taatgggcct ccgctgttcc 2888641 ccggattgat cgctgcatcg gtttgcagca cgttcatttc caccgtcccc tgtgttgtat 2888701 ccacatcaat tgtccggttc agtccgctaa tgataccttg tgtcactgta ccggaaaact 2888761 gctgtccgag cgggttaccg atagcgatta ccttttcgcc agtgcgcagc tgtgaagagt 2888821 caccaaagct cgccactttt tttacattct tgccgctgat ttccaaaact gccaaatcag 2888881 taatggtatc gctgccgaca agcttggcag tttccgtttc tccgttgtat agcgtaacag 2888941 tcagcttgtt cgcgccttca acgacatggt tgtttgtaat gatatacgct ttatcgctgt 2889001 cttttttgaa aataacacct gacccggttc cgctttcact ttctgagctg gagcctcctc 2889061 ccgtgccgaa tgtgttattt tgagaggttt ggatatttga gattccgaca atcgtaggct 2889121 ctaaatcctc taccatatca gcgatgtttg atgcgttcgt tatcggcgcc gttgtaaaat 2889181 tatcagactg cacctgttta tttgcggaag cggtttcggt cgcctgattt tggtctgacg 2889241 gcagataagg cgcgatgcca agcatgaggc ccccgccgat aataccgcct aaaatcgggc 2889301 tcagccatgc ggctctccgt ttcttttctt ttttcacagc cgtttcttgc ttttccattt 2889361 ctaaagcaga agccgtttcc tgccgtcccg cttcatacga cacaggcgcg tcaagcaatt 2889421 cttgttcaga atgtccaatc agcttctggt tttctgtatt ctgctgttct gtatgtgaag 2889481 gttcagtttg atgttgatcg ttttggccat cacgtcgata atccatgttc ttacactcct 2889541 ttaacggtta ttcatttatc gttacatatt catcgcatgt acaagttcaa ttgtcccaat 2889601 aatgaggaga aaagcaaagc accaaaatag aatatgtttg atcatcctac atcttcctcg 2889661 ctctttttct cttcctttct tcccttaacc atatcataaa caaacattgt gggataaaaa 2889721 tgaaaagaat atgtgaaatt atgaaaattg cctgccgtat gttaaaacta gtttataatg 2889781 acgttgaaag gatgtgaaga gccttgtcat acaccattta tctagttgaa gatgaggata 2889841 acctgaatga actgctgacg aagtatttag agaatgaggg ctggaacatt acatctttta 2889901 cgaaaggtga agacgccaga aagaaaatga caccgtctcc ccacctatgg attctcgata 2889961 tcatgctgcc ggataccgac ggctatacat taataaaaga aatcaaggcg aaagatcctg 2890021 acgtgccggt catttttatt tccgcccgag atgcggatat tgacagagtg cttggcttag 2890081 agcttggcag caatgactac atttcaaagc cgtttttgcc gcgggagctg attatccgtg 2890141 tgcaaaagct gctgcagctc gtatataagg aagctcctcc tgtccaaaaa aatgaaattg 2890201 ccgtctcctc gtatcgggtc gctgaagacg cccgcgaggt ctatgacgaa aacgggaata 2890261 tcatcaattt gacgtcaaag gaatttgatc tgctgctatt atttatccat cataaagggc 2890321 atccatactc tcgtgaggat atcctcctaa aagtgtgggg acatgactac ttcggaacag 2890381 accgggtcgt tgatgatctc gtccggagac tgcgcagaaa gatgcctgaa ttgaaggtgg 2890441 agacgattta cggtttcggc tacaggatga tgtcatcatg aaaaacaagc cgctcgcgtt 2890501 tcagatatgg gttgtcatat ccggcatcct gttagcgata tcgattttac tgcttgtgtt 2890561 attttcaaac acgctgcgag attttttcac taatgaaacg tatacgacga ttgaaaatga 2890621 gcagcatgtt ctgacagagt accgcctgcc aggttcgatt gaaaggcgct attacagcga 2890681 ggaagcgacg gcgccgacaa ctgtccgctc cgtacagcac gtgctccttc ctgaaaatga 2890741 agaggcttct tcagacaagg atttaagcat tctgtcatct tcatttatcc acaaggtgta 2890801 caagctggct gataagcagg aagctaaaaa gaaacgttac agcgccgacg tcaatggaga 2890861 gaaagtgttt tttgtcatta aaaagggact ttccgtcaat ggacaatcag cgatgatgct 2890921 ctcttacgcg cttgattctt atcgggacga tttggcctat accttgttca aacagcttct 2890981 gtttattata gctgtcgtca ttttattaag ctggattccg gctatttggc ttgcaaagta 2891041 tttatcaagg cctcttgtat catttgaaaa acacgtcaaa cggatttctg aacaggattg 2891101 ggatgaccca gtaaaagtgg accggaaaga tgaaatcggc aaattgggcc ataccatcga 2891161 agagatgcgc caaaagcttg tgcaaaagga tgaaacagaa agaactctat tgcaaaatat 2891221 ctctcatgat ttaaaaacgc cggtcatggt catcagaggc tatacacaat caattaaaga 2891281 cgggattttt cctaaaggag accttgaaaa cactgtagat gttattgaat gcgaagctct 2891341 taagctggag aaaaaaataa aggatttatt atatttaacg aagctggatt atttagcgaa 2891401 gcaaaaagtg cagcacgaca tgttcagtat tgtggaagtg acagaagaag tcatcgaacg 2891461 attgaagtgg gcgcggaaag aactatcgtg ggaaattgat gtagaagagg atattttgat 2891521 gccgggcgat ccggagcaat ggaacaaact cctcgaaaac attttggaaa atcaaatccg 2891581 ctatgctgag acaaaaatag aaatcagcat gaaacaagat gatcgaaata tcgtgatcac 2891641 cattaaaaat gacggtccgc atattgaaga tgagatgctc tccagcctct atgagccttt 2891701 taataaaggg aagaaaggcg aattcggcat tggtctaagc atcgtaaaac gaattttaac 2891761 tcttcataag gcatctatct caattgaaaa tgacaaaacg ggtgtaacat accgcatagc 2891821 agtgccaaaa tagactgtag atgttttgca gtctattttt ttatgtgaaa gaatagccgt 2891881 taaaatctct gtaatttgtt ttgagcggct gtttgcattg atgaacccat tttttctctg 2891941 acaaggtctg cttcggatat ttgactttct ccactttgat tcctctgttt cgcaagcggc 2892001 tgatcatttc gtccaattct ctcattctag attcaccctt tcgcttgagc tttgaccatt 2892061 cggtcatctc aatttataat ataaataata catgataaaa aaacaagtta caataaggtt 2892121 aattttataa cagacggtgt gactatatgg tcatatccta gcaggcctcc gggctccgaa 2892181 agggtggaac cattgaagga aaaagaaaaa ctgattattg aaacagcctt aaaactattt 2892241 gcccaaaaag gatacaactc aacatcagtc caggaaatcg caaaagaatg caaaatatct 2892301 aaaggcgctt tttatattta ttttccttcg aaagaagcgc ttcttctctc tatgctgaac 2892361 tactattatg ataaaacgtt tacccgaatt ttaaatatta aaacgaaggg cgacagcccc 2892421 agaacggctt accgtaaaca gctgaccgtc ctctatgaaa acattcttga acacaaagat 2892481 tttatcagca tgcagttgaa ggagggttct ctgccttaca cagaagaagt ggagcaatgc 2892541 gcaaaaaaaa tccgccagtc ctcacttcaa tttcatatcg acagcctgct gaacatctat 2892601 ggaaaaaaag cggaaccgta cactgctgag ctttgttttt taatagaggg catcagccag 2892661 atttacctgg aatgcatgat tttgctcggg tacactgtga agccgtctca attagctgat 2892721 atcattatga atcgaattga tgatatggta aaaggcatgt ctgaacgaaa cgataagcct 2892781 ttcatcacat tggaagaggc gagctcttta ttcggacctc ttacgcacgg acggcctgac 2892841 ccgctgactg aatcaattgt gaaaagccta cgtgacaaaa ttaacagctt aaacacaaac 2892901 tcctctcttg aattatcgga gagcttggac atacttgaag cagaaatgaa gaaaaaaaca 2892961 ccgaagctgg cgatcataaa aggaatgatt cataatctga cggagtctga agctctcgcc 2893021 aaagatgcgg aacagcttaa atatttatta aaacagcaac atatttagaa gaacggctgc 2893081 ttaaaaagca gccgttcttc ctattacgcc tttggtttta ccatgtcttc cggcttaacc 2893141 atttcgttaa attgctcctc tgtcagcaat tcaagcttca aagctgcttc tttgagcgtc 2893201 aatccctctt tatgggcaag cttggcgatt ttcgccgcgt tttcataacc gatatgcggg 2893261 ttcagcgccg taacaagcat taatgaattt gacaggtttt cctgaatggt ttctttatta 2893321 ggctcaatac cgacagcaca tttatcatgg aatgaattca tgccgtcact gagcagctgc 2893381 acagattgca ggaagttgta aataataaca ggcttaaaca cgttcagttc aaagttcccc 2893441 tgactcgccg caaagccgat tgtcgcatcg ttccccatga tttgcgctgc gatcattgtt 2893501 aacgcttcgc tttgtgtcgg attgacttta ccaggcataa tagagcttcc cggctcattt 2893561 tcaggaatga cgatctcccc gatgccgcag cggggtccgc ttgcgagcca tctgacatcg 2893621 ttcgcgattt tcattaagtc agccgcaagc gcttttaatg cgccatgcgc ataagtgatt 2893681 tcgtcatggc ttgtcagcgc gtggaattta ttcggcgagc tgctgaacgt ttggccggtc 2893741 agcttagtga tctcttctga gacaagctct ccaaactctg ggtgggcgtt gatacccgtt 2893801 ccgacagccg ttccaccaat tgcaagcgca cgcattttat ctgtcgcttc caaaatcatt 2893861 tccttcgaac ggtccagcat gtgaacccat ccgctgattt cctgtccgag ggtcagtggc 2893921 gtagcatcct gaagatgcgt gcgtccgatt ttgacaatat cattgtatgc ttttgctttt 2893981 tcatccagtg tattgcgaag ctgatcaagc gccggcacaa gctgctcgta aacagccaaa 2894041 acagcggcaa catgcatcgc agtcgggaat gtgtcgtttg agctttggct tcggttcacg 2894101 tcatcatttg gatgaatcgt ttgatcagag ttcttctctt ttaataaagc agtcgcacgg 2894161 ttggctacca cttcgttcat gttcatattg ctttgtgtgc cgcttccggt ctgccatacg 2894221 acaagcggga agttgtcatc gtacttgcct ttgagcacat catcacaaac cgctgcaatc 2894281 gcttctgctt tttcagcgtc cagattgccg aggcgtttat tagctagagc agtgcttcgt 2894341 tttaaaattg caaacgcctt cacaacacgc atcggcattt tttcagaacc gatcttaaag 2894401 ttctccttgc ttcgctgtgt ttgggcgccc caaaatttat cagcaggaac ttttacttct 2894461 cccatggtgt ctcgttcaat tctgtattcc atttatgtat ccctccataa cggttgcttc 2894521 aatagatcat aattcgccaa tgacacaaaa aatccttttt atttttcgat cttggcagat 2894581 tttaatttta attcaagata tacgcgggaa tcctttgaat atttgtattt tggatttgtc 2894641 ctgccgtact cctttgatgt ataagagaca tcataatgct gttcaaatga tctaatgagc 2894701 tgttcaattt cttcttgttt tccagctagc cttacctgtg ccacttcgta tcctccgctt 2894761 tcataaaaaa acttactcca tgaaatactc taacacagta tatcattttt ttaacaggaa 2894821 aagataacct ctactaaggt tttggataag aggtgacctc attggaacaa acagagttta 2894881 aggaatatat acacgataat ttagcattgg tgctgccaaa attaaaagaa aacgatgatc 2894941 tggtgaaaaa caaaaaaatg cttgcgaacg gactggtttt ttactatctc tatttcagtg 2895001 aaatgactga tgagaataag gtgtcagaag ccattaaaac tttgattaaa gatgaggaga 2895061 ccttaacgct tgaccaggtc aaaaaacgcc ttgaccagct tgacgcaaga cctgttgaaa 2895121 ctgcaaaaaa aacgattgaa tcgattctca acggcaattg tgctgtgttt atcaacggat 2895181 tggataaagc ctatattctg accacaggaa agaaaaaaac aagaagcctg acagagccga 2895241 caactgaaaa agtggttcgc ggcccaaaag tagcgtttgt agaggatatt gatacaaatc 2895301 tcgctctgat cagacaaaga acctctcatc cgaaattgat caccaaaaaa atcatgatcg 2895361 gcgaaaacaa gctgaagcct gcagccatta tgtacattga aggcaaagca aaaaagtccg 2895421 tcataaaaga agtgaaggcg cggcttaaaa atatccagct ggaagatatc caggacagcg 2895481 gaacgctcga ggagctcatt gaagataata aatattcacc atttccgcag atacaaaata 2895541 cggaaagacc tgacaaagta tcttcagccc tgtttaacgg ccgtgtggca attttggtcg 2895601 acagttcacc atttgtgctg ctggtgccgg tttctctcgg catcctgatg caatccccgg 2895661 atgactacta tgaacgctgg atttcagcat ctcttatccg gtcgctgcgc tttgcttcta 2895721 tctttatcac cttgtttttg tcatcgattt atataacact tgtttccttc catcaggggc 2895781 tgctgccgac cgcactcgcc gtcacgattt cggcgaacag ggaaaacgtg ccgttccctc 2895841 cgatatttga agccctgctg atggaagtca ccatcgagct gctaagggaa gccggactgc 2895901 gactccccaa tccgctcgga cagacgatcg gcctcgttgg gggcgtagtc atcggacagg 2895961 ctgctgtaga agcgaatctc gtcagttcga ttttggtcat tgtcgtcagt gtcattgccc 2896021 tggcatcctt taccgttcct caatacggaa tgggtctgtc tttccgggtg ctgcgtttta 2896081 tttcgatgtt ttccgccgct attttagggc tatacggcat tattttattt atgcttgtcg 2896141 tttatacgca cttaacgaga caaacgagct ttgggtctcc gtatttttcg ccaaacggat 2896201 tctttagcct gaaaaatacg gatgactcca ttatccgtct cccaattaaa aacaaaccaa 2896261 aagaggtgaa taatccaaat gagccaaaaa cagactccac tgaaacttaa tacctttcaa 2896321 ggtatttcta ttgttgcaaa tacaatgctt ggggccggac ttttaacatt gccgcgagcg 2896381 ctgaccacta aggctaatac gcctgacggc tggatcacgc tgatattaga aggtttcatt 2896441 tttattttct tcatttattt aaacacgctc attcagaaaa aacatcaata cccttcactc 2896501 tttgaatatt tgaaggaagg gcttgggaaa tggatcggca gcatcatcgg ccttttgatc 2896561 tgcggctatt tcctcggcgt agccagcttc gagacacggg caatggctga aatggtgaag 2896621 tttttcctgc tggagagaac cccaattcaa gtcattattt taacgtttat ttgctgcggc 2896681 atttatttaa tggttggggg cttaagcgat gtgtcgcggc tgtttccctt ttatttaacg 2896741 gtaaccatta ttattttgct gattgtgttc gggatcagtt ttaaaatttt tgatatcaat 2896801 aatttgcgtc ctgttttagg cgaaggcctt ggacccattg caaactccct taccgtcgtt 2896861 tccatctctt ttttaggaat ggaagtgatg ctgtttcttc ctgaacatat gaagaaaaag 2896921 aaatacacgt tcagatatgc gtctctagga tttctgattc cgattatctt atatatcctt 2896981 acgtatatta tcgttgtcgg agctttgacc gctcccgagg tgaaaacgct gatttggccg 2897041 actatttctc tctttcagtc ctttgagctt aaaggcatat ttattgaacg gtttgaatcc 2897101 tttttactgg tggtctggat tatccagttt ttcaccacat ttgtcattta cggatacttt 2897161 gccgctaacg ggctaaagaa gacatttgga ttatcgacta aaacaagcat ggtgattatc 2897221 ggcataacgg tcttttattt ttctctctgg ccggatgacg ccaatcaagt catgatgtat 2897281 agcgattatc ttggctatat ttttgtctcc ctgtttctgc ttccgttcat tctctttttc 2897341 attgtagctc tcaagaggag gattacaaca aaatgaaaat ccggatttta tgtatgttta 2897401 tatgcaccct attgctgtcc ggatgctggg acagtgagaa tatcgaggaa ttaagcttag 2897461 tgatcggaat agggctagac aagcctgacg atgaaaattt agagctgaca cagcaaattc 2897521 tcgtgccgaa aataatcagc gccaaggagg gctcttcatc tgatccgaca cagctttcta 2897581 tcacaaaggg taaaactgtc catcaaatga tgagaacctc tgcattaaag cataagccta 2897641 cgttttcaca gcatttgcgt ctcattctgc tttccaaaag cgtgattgcg gatcaaattg 2897701 gaatggacgc cattattaac cagtttgtca gagacaacgg aacaaggagg agttcctacg 2897761 tctttatcac caacggccga actaaggata tatttaacat gaatgatgaa ggcgaacccg 2897821 catccaacgt gatatatgat ctgacagaga ataataaggt gacgatcaga acgatggagc 2897881 cagttacatt gggggagatc tcagaacact taacctctga cgattcattc ctcatccctc 2897941 atgtcggtaa ggaaaacggc aagctcgcga taaacggagc ctctatcata aaaaataaat 2898001 tatggcaccg ggacctcacc ccgattgagg ttcaaaatat cagcttattt tcaggcactg 2898061 tcgagggagg cgtcattgac ttgaagcgcg atggccatct cttttcttat gaagtatatt 2898121 caagcaatcg gaagatcaag acggcataca aggacggaaa gttcaaattc accgttaccc 2898181 gcaatattga aggtcgtcta tctgaggact ggaatcccaa tgaagactcg tttaaggatt 2898241 catatattaa aagtattgaa aagacagtcg aaaaacgagt acacgaaaca gtaacgtcat 2898301 ttattacaga gaagctgcag aaagagatca aagcggacgt aaccgggctg ggaaacgagg 2898361 tcagaattca ttatcctcaa aagtggaaaa agatttcaag aaaatgggat gatgattatt 2898421 tcagcaatgc ggaaatagac taccgggtca atgtgattgt cagagacttc ggaacgaaag 2898481 gcgcaaacaa atagcagccg cctaattcac gagatgattt cggtgtgcgt acaccgccgc 2898541 ctgcgtccgg tcactgacat ccagctttga taaaatattc gtaatatgtg ttttgactgt 2898601 tttaatcgta ataaacagtt cctcgcctat ttctttgttt gtctttcctt ctgcgatcag 2898661 gcagagtatt tcgagctccc gttttgtaag cgattcatgc gggagcgcgt tttcacctga 2898721 gtggcgcagc ctggataata cttttcccgc cacttttgac tccagcttcg gctctccctt 2898781 gcttgcggcg cggatggcat cggcgatttc tgccgctttt gaggttttca acagatagct 2898841 gagcgcgcca gcttcaataa ccgggtacac tttgtcatca tcaatgaagc tagtgagcac 2898901 aataattttc gggtcggaaa gctcccggca aatttgcttt gtagcttcaa tgccatccat 2898961 gccctccatg acaaggtcca ttaaaatgac atcaggcgac agttccacag caagccgaac 2899021 accttcgctg ccgtccgatg cttcgccgat gacttcaata tcgggctgcg cctccaaaaa 2899081 agccgcgagc cccattctga ccatttcatg atcatcaatc aataatactc gaatcacgtt 2899141 cgttctctcc tttttcttcc ggaaaaatcg ggaccttcac ttcgatttga gtgccttttc 2899201 cttctactga aatcacttcg gcgacaccgc cgatttcact tgcacgttct ttcatagaat 2899261 tcaagccgta tgaggaggct ttcacctggt ccattttaaa gccttttcca ttatcaatca 2899321 ccttcagacg gagctggctg ttctttatgc ccagaatcac ggttactttt gacgcttttg 2899381 aatgtctaaa tacgtttgaa agggcctcct gcacgattct gaacaagtgg tcttcaacac 2899441 ccttggatat cgctgtgtcc tgtatatccc actcaatatc aatcggctgc ttttttcgga 2899501 actcgtccaa aagctccgta aggccctcct tcagcccttt tccttcaagg gtaacaggcc 2899561 gtaaatggag cagcagcgcc ctcatctcat tttgggcttc gcctgccata tgctcgacca 2899621 tcctgatccg cttgactgtt ttgtcatcag catccttgac atgttccagc acggctgatg 2899681 tcatcatcga tatggcaaag agctgctggc tgaccgcatc atgaagatct ctggccaatc 2899741 gctggcgttc ttctgagata accgacttct tcatttgagc ctgccattcc gcacgttcat 2899801 tggaaagttt ctggagggat gcgacttgaa gctccacgcg cttcgccatt tcgttcagct 2899861 gatcagcagc caggccgatt tcatcatcac cgagcggcgg tatccgataa gcgaaattgc 2899921 cgttttcaaa ggttaaaatg gattcaatta atgtatcaat ccttgtcttc aaccggttgc 2899981 cgtacatata ccctgaggcg aaaccgacgg tcacgctgat cagaagcaaa atcaggataa 2900041 acggaattcc gaaccagctt gatgacagca aaacaagcgg atcgagccga tagtaaaaca 2900101 tcataaagga aatcaggcaa acaaaaagga gcaggctgat tcccgttgtc atgcggatgg 2900161 cgcgccattg gaggctggca agcatttttt ttctcatacg tacttcacat ccacatcacc 2900221 gataaataag gaaacggaca cttttacccg gcgctttgac tcgctaaaat cagttgacgc 2900281 ggcatatacc ttcgtgctta atccgctttt cttcgagccg atcagattaa tgtctcctat 2900341 aaaaacagcc gagctgacag ccacttcaag gtccgatggt acataaatat caacgttacc 2900401 aatgactccg ctaatgacga ttgtactttc tccctcggga atcatcgctt tagataaatc 2900461 gattttgata tcaccgataa aaccagagac atttaaatcg ttcaggtcaa acggctgctt 2900521 catcatttgc agctcaccga taaaaaagct gcgcatgtcg ggatgtttta catcttttgg 2900581 cggctcatga tgttcttttt tattgagatt gacctgtttc tcattcggtt caaatatcgg 2900641 cttccctttg ataagcctgt agccggcgta aatcagaaat gcggcaaacg catagccgaa 2900701 taaattaaag gtgatgctga agaggttttt caaaaataga aacgcggcaa agatatacat 2900761 gacggagcca agccaatcac gggaatattt tttaaggaaa tagccggcaa tcagaaaaaa 2900821 gagcggccaa aacagcagat cgcctattcc gataatttgc aaaaacatac tgatgccgaa 2900881 taaagcaatg atcaatccga gaagctgttt ttttgtcatt cctggtgtcc gcctcctttc 2900941 ttctgcctag tgctaccgta tcgctagatc cccgctgtcc gttttgatgt cgattggatg 2901001 ccggccgctt ccttgcgtgc ctgtgatgtg atgctgttct ttatgtcctt tatcagcaaa 2901061 tgaatacggc gaactgacgt caccgcttgc tgataaagca ttgactgcaa agctgccatt 2901121 ttggggaagg cttacattag catcaccgct tgtcagcgtg acagatacgg gaccggttac 2901181 ctttttcaat acagcattaa aatctcctga agtcattttc acatcaagag agcctgatac 2901241 atgaaccaga tttgcgtccc ctgaagctaa atcaatgccg gctgttttgg agacggtatt 2901301 tgaaatggaa acatcccccg atgatgcctt cactttcaga tcttgaatgc ggacgtccgt 2901361 cacgctcgta tttccgctcg cagatactgc gttcagcccg gaaagcgcaa gatggtcatt 2901421 cccggccaca gacacgtcac cgcttgaggt tcgtactgcc agatcacctt tataatcata 2901481 cggaagcctg acgataagag ttgaacggtt aaatccattc aaaaattgaa attctttttc 2901541 ctttacggtc agctccagtt ttcttttgtt ttcagtaaca aataactttc ctgagtctcc 2901601 tgaaatgcct gccgatatgt cacttcgttc ttccgctata atccggacat ccttgctatc 2901661 cgactcaatg accatgctgt caatgtcccg cggcgatgcg ctggctgaat cagcttctgt 2901721 gccatttatg aaacctaggc ctgcagcaaa cacatctttt acgacgacgg cgaaaaaaac 2901781 cagaataccg gcagtgatca acagtttgcc aagcattttt ttcattcggt ttcatccttc 2901841 tcattcattc tattataaag gaaaagcttg cgaattgata cgtgcggaag ggaaggactt 2901901 gaccgcaaat ccttccccgt tccgcttatt catttgccgc ttttgtctgg tctgattttt 2901961 gcagtgaaag tgtccgcatt ttttcaatct ccgcttccac atcgtctgcg aattctttac 2902021 gtgtaagttc tgtgccggct tccgctgact ttgaataatt cgcgcggatt tccatttctt 2902081 caatacgatt ttcaatacgt aaaaattcac gatacgcgct ttcactgtca attttgtcaa 2902141 atgtcgtatt catatgctct ttagctttcg ccgcatttgc ccgcgcaatc agcgcctgtt 2902201 ttttatcctt tacgtcctga agctttgttt caagtgcagc cagctgctct ttcagatcag 2902261 ccagctgact gtttgcctgt tcataggaag ctttatgctc agccgccttc ccttctaaat 2902321 acttcatttc agtcagcgcc tttttcgcca gttcttcttc acctgcgtca aatgcgagct 2902381 gtgcctgatt tttccgtttg ccagccactt cagcggcttc ttcatatttt ttcttaaatt 2902441 gataggcaat cgtgtgctgt ttcacaattg tttgctttgc ttttgcgatg tcgctttcca 2902501 tatcgcgtac atattgattc agcatcacct ttggattctc cattttatca agtccttcat 2902561 gaactgacgc aacaaacatg tctctgattc tttttaatac catacctgat tcctcctaat 2902621 atattgatat tattttttct tcaaaaattc ttcccattcg tcatcaaagt gagattggta 2902681 ggcagcagaa gccggttcag gatcaaaaga tgatacaccg ttatcagctg atccgttttt 2902741 catcagcttc cagccgtaat acaccatagc ggccgccaat gcgattccga cgacaaacgg 2902801 aagtgagcag atgagcataa tggctccgat accgcccacg atgattcccg tgatggtttt 2902861 tcccgcggca aaccttttga ttcctgcgta tgtcatcaag ctcccgatgg cgagcgggat 2902921 gataaagccg aagcttcctc ctccaaaaaa gacggagatc ccaaatacaa ttaataagaa 2902981 tccgcctatt gttttcttgt ttattttcat gcagatcctc ctttcgtttt ccttgtcttc 2903041 atcttataca agttggaaga tatgcaaaac gaatcagaga ttgattttta tataagaccg 2903101 gagtcgtatc tcgcaccgga cccattggca caaaaaaacg ccatgcacga ggcatggcgt 2903161 tttaaaaccc tttacagatg aacacttgct tccctttctt taattaggtc ggacctttct 2903221 gctttggcca attttgtaaa cagcaagatt ccgatacccg caataatttc gacaatccca 2903281 ccgacagcga tcactttacc tgagccgaaa gcattagcgg catacccgca aatgacagct 2903341 ccggcaggga tcgaaatatt tgagatcata tgtataacgg cgtaaacctg cggctgatcc 2903401 tcactatcca cagacgtctg gataatcgtg tactcaggaa cattaacagc actgactgcg 2903461 gcaccaaagg taaaagcagc gaaaaagacg agcggcaaaa aggtattcat cccggtaata 2903521 aagaaagcaa atccttcaat aatgccggca gtgacgaata acaagccgta cctgtttacc 2903581 ttgactttcg ccagcacaaa ccctaataaa aacgcgcccg cggcggtggt ggcctttaaa 2903641 agcgagtata cgatcggctg gccgtttaaa tcttccgcaa cgtatacggc agagagcgct 2903701 tcccatgggg cagccgcgaa attcataaag atacagtaaa tggcgagcgg atataaaatc 2903761 tggtgttttc tgacgagcct aaagccgcgt ttcagtcttc cgatatatgt gcctctctgt 2903821 gtaacaaccg cagactctga ttgagattca accgcagtgt acttaataaa aagaacgaga 2903881 aaacctgaca ccaaatagag cacaagtgcg ataagcatgg tataagaagg actaataaat 2903941 gtaagaaaag cgccgcataa tgtgacagcc ccaagccgga caatttgagc ggaggattgc 2904001 agcacagcgt ttgctttttg aatgccctgt tcattgacga tttgaggaat caaagcgata 2904061 gaggcgggat tgtaggcagc tccagtagct gaatgcacaa tcataagcgt catgacaaac 2904121 cacagcggag agaagcccgc aaaatgacat agagggataa tcaaaacaat cgccgccctt 2904181 gtcagatctg aaaagtacat ccaaaatttc agcgtggtct gtttcataaa aggccccgtc 2904241 acaggcgcca gaacggcttc cggcaaaaac gtgacagcaa tcaataaagc agtgccgatc 2904301 gcacctttgc cgtcataaat taaaaaccat aatattgaat taaatgcgaa catatcgccg 2904361 gatatcttga ctattcttga gaaaaacaga taattgaaat ttctcttcca gatgctatca 2904421 ctttcaatta aattcaccat ccatcagagc cccccgttgc ctatttttta catctattta 2904481 ttacaatatc tcatttttcc atttttcagt caataattca taaggttcat tttttgtcgt 2904541 aaaatgggaa attgacagag tgaaaaacaa aaaaagccgg catgtatttg aacacgccgg 2904601 ctttcctttt cactttttat gattcgctgc tgtttcggtc ccgaaacaca atggcacttc 2904661 tttcatattc tacatcgcca ataccgcttc ttgcattcac aacccgggcg gcggcaaaga 2904721 aataatcgga cagacgattg agataacgca gcactgtttc atgaatctcc tccgatttca 2904781 tcagcgccac cactcttcgt tctgcccgcc ttgtaatggt gcgtgcgata tggagaagcg 2904841 aagcacactt tgatccgcct ggaagaataa atttcttcag ttccggcgct tctgctgtat 2904901 aggcatcaat gcgcgtttct aaaaaggaaa cagattcttc cgttagttta tagtcttttc 2904961 tttctgtgac gattgccaga tcgcctccgc agtcaaacag ctcatgctgg atggtcagca 2905021 gctcggctgt cagatcttca aagccgggct gcccggaaag ctctgccaaa gcaagcccga 2905081 taaagctgtt aagctcgtca atcgtgccgt agctttcgac gcgtaggctg tccttgtccg 2905141 ttctgccccc gactaagccc gtttgtccct tatcgcctgt ttttgtatat agtttcatac 2905201 cctgaatctc ctttacagac ttattcaaac aactcagcag cctcttttat acattcagct 2905261 gtccctttct ttatcaattg gttcagccgc tgttctatgt tttctgattg ctgagtttga 2905321 gtcgcggcga tgagaatatc acctgtgcct cctccgtctc ccagcacttt cgtccgttct 2905381 gcttcggcag ccataagagc tttgatgaag aattgatctg ccgcatagcc gttaatcaaa 2905441 atccaaatcg aaaagccggt ctgaacgcat atgaaaacgg ataactctcc gtcttcatat 2905501 gttcgataca cgaaacggtc aagtctttct gaagaagcca tcgcacacgt ctcctgcagt 2905561 tgaaaaccgc tttctgaaag acaggccgta agtccttcta tcggatctgg ctgatctggc 2905621 agccgtttat ggatcagcgt cctgctccac gaaaaccctg caccgatagg cgtggaggac 2905681 aatgttcgaa gcgggatttc cgtttgcaga agaatgtcat cacgccccgc ttggagcaat 2905741 gcttcaaatg ggatagactg ccgcttcacg ctatcttttt caggctgaat cacaatcatc 2905801 ggtttaggtg agctttgatg aaccaaggcg gtgacatctg tatcgtacac cgcctttatg 2905861 ctttgttctg taacagcata ttccggtttt tgcttaggcc cggcggtacc gtttttcata 2905921 aacatgagcc catcacagta caggcttgcg gtgttcagat catgaaaaac gctgacagct 2905981 gccaatccgc tttctctcgt caggcgtttg atcagatcaa gcaggtcttt ttgataagcc 2906041 agatcgagaa aattagtcgg ctcgtccaaa aataaaatac gcggctgctg cgccaaagct 2906101 tgtgccaaat acacccgctg ctgttcccct ccgcttagtt cgcgaatcgg cttttgcgca 2906161 aaatcggcca ctcctgtttg ctccattgct tcctgtacaa tggcttcacc cttttcagtc 2906221 tgctgtctga acagccccgt ttggaatgga tatctgccaa aggctacagt ttcttcgaca 2906281 gtaaaggtga aggcttgatc cattttttgc ggcaggacag ccatgatttg cgccagttcc 2906341 ttcggtttat agtccgccag cagttttccg gccagataaa ccctgccttt cttggccggc 2906401 agcgtacctg tcagcaagtg caaaagcgtg gtttttccgc ttccattagg gccgagaatt 2906461 ccaagaaatt ctcccttctc cactgttaag ctgacattgt tgattaggcg gctgtcgccg 2906521 tatcctcccg acagcccttc tgccttcatc ataagcttct ccccccgcga tgctgccgaa 2906581 ttaaaataag agcgaacaca ggcgctcccg ccaaggacgt aatgatcccg atcggcagtt 2906641 caatcggctc aatgatggtt ctggaaagca gatcggctaa aacaagaaac cctgccccaa 2906701 gcaaggcgga caacggcagt aaatgccgat ggtccgttcc ccacaaaagc cttgtgatat 2906761 gcggaatcac aaggccgaca aagccaatcg tacccgatac tgccacagcg cttcccgtca 2906821 aaagagatcc ggctattaaa atcatcatct tcctctgctg aacgctgact ccaagaagct 2906881 ttgctttatc ttctccatat gtcatcacgt tcagttccct tccgtttata atcaataaaa 2906941 tggttcccaa aagaaaaaac gggagaaaca aaataacata gctccagccc ctcattgaga 2907001 cgctgccaag cagccaatgc acaatcggaa gcaggttgtc tcctgtcaag gcgatgataa 2907061 gagaaataaa tgcgcctaaa aaagagttgg tgatgacacc ggtcaaaatg agggtggaaa 2907121 cagacatcga agcatgaacg aggcggctga agaaaaggac cgccgccatc gtggccagtg 2907181 ccgcggctac actcaaaacc gggagtgtaa accctccgat gacaggaagg tgcaaaccta 2907241 agaacagagt cacaacagct ccgactgaag caccggatga cacacctagc gtatagggat 2907301 cagcaagcgg atttttcaac aatccttgaa aagcggcccc tgcaatagaa agagccgccc 2907361 ccacaagggc ggccagcaca actctcggca gtctgatatt catcataata ttagtgtaca 2907421 tcggatcatc agaaccgata gagccgccga aaccttgatg ccaaaagaca cgaaaaacag 2907481 cgggaatagg aatatgcagg ctgccgcaag aaattcctaa gatgatgctc acggctaaaa 2907541 atgagaaacc aatgatatat gcggcataac gattattcct taaacgtatc cgggtaaatg 2907601 ctttccgcaa gttcttcgac cccttcgatc agacggggac cggaacgtgt cacaagatca 2907661 gggtccacat catatacacg atgatgtttc acagcattga tttcgctcca gccatcgcgt 2907721 ttttccacag ctttcgcttt cacaccgtcc gttgtaacaa ttgcatcagg attgagtttt 2907781 acgatcgcct cgtctgtcat ttgcacccat cctgtctgat ccgcagctgc gtttttagca 2907841 tggatgacat ttagcatttc attcataaac gtatcttttc cggttgtata aatgtcagga 2907901 tcaggagaaa cctcgataaa tacgcttttc tcctcgtctt ttgaaatggt tttcgctttt 2907961 tcttgaatat cctttagatc tgatttcatg cttttcacga gctgatcggc ttttttctcc 2908021 gccccgccag cttctccgat catttcgatt gatttgtaca cctcggagaa tgattgtgca 2908081 tcattgacag tcagcactgt aatgcccgcg tccttcagct gtttgatggc atccgctgat 2908141 gctgacatgg aagactcatg ggccagaacg agatctggtt ttagagaaat gactttttca 2908201 acgtttacat tcatatctcc gactttctca acctttttga cttcctttgg ataggtatcg 2908261 tttgtggtga caccgaccac tttgtcacca aggccgagtg cgtatgtaat ttctgtgttg 2908321 ctcggcatta atgaaacaat cttttttggc tcttttttga tggttacatc ttggtttgac 2908381 gcatcatcaa tggtgacagg gaacacttct gttttttgtt ttgcctttga atccttctga 2908441 tccgcaggat tgccgcagcc tgccagcata acagcagcca acagaagcgc agcccatatc 2908501 ccggctcgtt ttttcataat cttttcctcc taaacgaact aaaaaagcat ctctacgacg 2908561 gtaaagatgc tgtaaacaac acaaaaaagc ctattgttta cacatcatct gtcctcgcag 2908621 aattcgtgct gatcaaacag gcaggtatcc tggctcttgg cgcttggcca attacagtgg 2908681 cgggaccgca ccggctttta ccggtttccc ttttaagccg gctgttgttc acggaccggc 2908741 acctatttga cattcgtatc cgtttttcgg agtaattata ctatatgact gacaggcttg 2908801 tatatgtgtc ctgaatgact tttccccata ttgtgtatgg aagcaaaatc ctcgtaaaca 2908861 ctaaatttga tcttgtatac ttaataccat catctatcaa aaggaatgat tcttatggat 2908921 ttacagctaa aagaaaaact cgtcttaatc accggctcga cgtccggtat cgggaaagcc 2908981 gccgcaaaaa gctttctgca agagggtgcg gcagtcattg tcaacggacg caaacaggag 2909041 actgtcgatc gcaccattga agagctttct ggctatggaa cagtgcacgg tgctgctgcc 2909101 gatttgtcaa aaacagatga agcagcggct tttatcgaaa aagtaaatga aatcggtgat 2909161 atcgatatcc ttgtcaacaa ccttggtttc ttcgaggtaa aagacttcgc cgatgtgaca 2909221 gatgaagagt ggaatcaata tttcgaagtg aacgtgatga gcgccgttcg gacaagccgt 2909281 cacttccttc caaaaatgct tgccaaaaac agcggccgca ttttaaatat tgcaagtgaa 2909341 gcaggcgtca aaccgctgcc aacgatgatt ccatactcaa tgacaaaaac ggcactgatc 2909401 agcctttcaa gaggaatggc tgaaatgaca aaaggcacaa atgtgacggt caactcagtg 2909461 ctcccgggac ctacttggac agagggcgtg gcctcctata tggaaggcgc cgcacaagca 2909521 gccggacagg atacagatac atttatcaaa gactatttca aggtcaatga gccaacctca 2909581 cttattcagc gatacgcgac agcagaagaa gtcgccaaca caatcgtatt cctcgcgtct 2909641 gacgccgcat ccgccattaa cggcacggca cagcgtgtgg aaggcggcat tatccgttct 2909701 ctgtagtata aaaaaacgca tccgtgtttc ggatgcgttt tttttatacg tctccagcaa 2909761 atggtaccgg ctgatatccg cctgtttcca gttgtgctga aaacaaccct ccagcgtgag 2909821 gctgctcgta tctctctttt tctgtcattt gttctgttgc cgttgtaatg taaagggttt 2909881 ttaagtctct gccgccgaac gcgcagcacg tgacatattt agccggcacg ctgattgaat 2909941 tgatttcttt tttctgaaac gggtcaatgt gaacaacgcg gctgccgcca aacagcgcca 2910001 cccacagcat gccattttgg tcaattgtca tgccgtccgg caatccgtct gactgatcaa 2910061 aacgatagac aggttctgga ttcgaaacat ctccgctttg aggatcatag ctgtaacgta 2910121 caatctcctg ggtcggcgtg tcgatgtaat acatcaaatt ccgctcgcgg tcccaatcca 2910181 aaccgtttga ggtggagact tgatccttga ttttgacaag actgccgtct agattcaaac 2910241 ggtacagcga cgcctgtttt tgctcgcctt ccatgctcgt cgtccccgcc caaagccttc 2910301 cgtacgggtc acatttagca tcattaaatc tcaggctctc atgcatgtcc ttcggctgtt 2910361 taattttttc caagctgtca tcccgaagat gatacaggta aaacccgtcc ttcatcgtca 2910421 taatcagttc atcctttgaa tatttcgcaa gcgccgtcac aaaggatttg aatttgattg 2910481 atcggttgat tttttcttca gggtcaaaga tgtggagctc gctccccagg atatcaaccc 2910541 aatataagcg gccgttctct tcatcccata acgggccttc accaatcact gcccgagtgt 2910601 ctgcttccaa tactgcatcc atgtgttaca cctctttagc ttcagtctat atattgttat 2910661 tcccggcaaa gaggtgtcca aaccacttga tgtttattgt tttttaaaaa ggatggtaat 2910721 gaccgttcca atgttcgttc tgctgttcac atggatcgtt ccgttatgca gatggacaag 2910781 ctccttggca atcgcgagcc cgagacccgt tccggcagtt gaatcttttg tgttcgtccc 2910841 tctgtagtag cggttaaaca aatgggtgat cgtttcttca tccattcctt tcccattgtc 2910901 cttcactttt aaagaaatat gattttttgt ttgctccaga atgacttgaa tctctgttcc 2910961 tttgccgttg tgcttcacgg cattcccaag gaggttttct aatatgcgcc tgaaccacgc 2911021 ttcatcaagg gcaaattcaa tatgctcttc tttggataca aacgagatat catagccttc 2911081 agaaaacgga tttttcttaa aatcctcaat gacattttta aaaaacggga taaggctagt 2911141 gagctttctc tcaataggaa gagcatcatt tttcaggcga tacgttaaat ttaagtcttc 2911201 aatcagctta gacatgtatt cagatttttc tctgacaacc tgccccattt ctttcacttc 2911261 ttccggcgac cagtcatact gcttcgactc gagcatcatg ctgtagccgt aaatgctgct 2911321 gagcggtgtt tttaagtcat gtgacaaacc ggcaatccat tcttcccttg tcgcctggat 2911381 tttttctctg tttcttttat cccttctcag cgtttcagtc agctgatcca ttgattcaaa 2911441 tatctcaccg aagaagcggt acggctgttt gatttttccc tttttatttt tgctgacagg 2911501 acggccttcc cggtttctgg gctcctcaag cttccctttt gacagattga ccagccatct 2911561 aatcgtgtga aaaatcggca gcccgaatcg gaacatatac caaacggtca tccaaatgat 2911621 atacatgaac aaaacggcca tcacgagaaa catcgctttt aatacaacct tcaggaatga 2911681 tttgttaaac tcctgatcgg ttacatagac tgggttcggc accgtagcga ccatccatct 2911741 gtctttattg aggatcttaa cggaaatttc ccgcttatag ttccaaggct tagagctgta 2911801 tttaagcagc tccagctggt tcatcgtttt tctctcgctt tttgtgctgt tgatgctgtc 2911861 gagaatcttt ccattgctgt ctaacaggta aatggcgcct tttttccgtt taatatagtc 2911921 gatggtacta gacttatagt gcgctagtga gtctatcttt tgttcacgct tttcaacgga 2911981 agtcaggagc tgttcacttt ttgatttcca gccggacaat agaagatacg acttatcttc 2912041 aatattgatg gcccaataat tcagtttata gttatgaagc tttttggttt tataaataga 2912101 caaaagctct ttcttggtat aggtgcccgg cacgtctttt ggcacgccgt aggaataatc 2912161 agtgtttcct tccgaatcaa tgatttgcat ccagccgtgc tgtttatcaa cagatttctt 2912221 caggaaatta tccacttccc atgtcccgtc ttcgtttaca tcgagatatg cctcaagtgt 2912281 gtcggtcgtt gctttcgtca gccctgaatt ggattccgca tcgctaaaac gggcgtctaa 2912341 atagaaaaac gatgcaacaa gcataaccgt aagcagcagg atcacaatca gcatctggcc 2912401 gaaaaagtga aacaaaaact tccatcttaa cctcatgacc gcttgccttc aggatttggg 2912461 ataaaacgat agccgagacc tcgaacggtt acaatatact ccggattgct cggatcgcgc 2912521 tcaatcttct ccctaagctt gcgaatatga accatgacgg tgttgttgtc accgtaggaa 2912581 ggatagcccc atactttttc atatatttga tctttggaaa gcaccacgtt agggtgttca 2912641 caaaaatact gcaaaagctg cagaagctgg gctgaacagg caacggcttc cccgcctacg 2912701 atcaactcgg cattttgcgg agaaaaagta aagtaatcat atgtgtaggt ttgatttgaa 2912761 ctcgtttctt tcgattgata tgtacgcttg agatgcgctc tgatccgcgc cgctaattcc 2912821 agcggattaa atggttttgt gatatagtca tcagctccaa ccgcaaagcc cgataatttg 2912881 tccgcgtcgg atgatcttgc cgtcaggaaa aaaatcggag cgtctgaata ctctctgatc 2912941 aatgtgcagg cttcaaaacc ggacattccg cccatcatga catccagcac aatcaagtca 2913001 accttattgg ccttcacaac gggaatcgct tcttctgcgc ttgccgcatc cagtatattt 2913061 cgataacctt ctttttcgag aacgcgtttg atcatgtcca caatcgcttt ctcatcgtct 2913121 acgattaaaa ttgacgcatt ttccactttt atgttccttt ctgtcactgt ttttttcatc 2913181 ttatcattat atcgtttatt tatggtacat ttttgaatac attggagcct tggcaaatca 2913241 aaacagcaaa aaaggagcaa acaagcgctc ccttttgatg ttttttcata tgaaaatatt 2913301 atgagttctc atctaccatg tacaaaataa actcccaaaa ccccggtaca tcctgacata 2913361 aaagcatatc agccttttca aacattttga tcttcagctc ttgctctaaa tcttctcttt 2913421 cttgatagga cgtattgctg agtttttttc tgatcatcgg tgaaaagcat gcaatcaggt 2913481 gctcaatgtc ataagtctcg tctttttgtt tctttttttg ttcaaactgg ccgtccacag 2913541 cttacttttc cccctttttt tgcgccgcta actgctttct gatattctcc agcccctttt 2913601 tatgaatgtt ggagatgttt tgtcgggact cccctaatga atctgcaatc tcctgcatcg 2913661 tggcaccgtg aagatagact ttcgtcagca cacttttttg tttgtcagtc agcttctgga 2913721 tcgcttggta gagctggtaa tcctgtacat gctggctcaa atcatcctgc ctgtctaaaa 2913781 attcttcaaa tgcatcgcta cctgtttcgg aagaaagccg atctcccgcc tccggatgat 2913841 caaccgtcag tggataccgt ttttggtttt tgcgaacccg cttatcaaaa tcaatagaaa 2913901 agatgcgaat cattgaattc atatacttga cgatgcggat ttctttataa aattgcttaa 2913961 atagctcgtc caatgatctt gcatcttttt cgttagggct ttccattacg tttttgaaca 2914021 aacggtaatg ctgaggattg ctcaaaaaat gcttcacgat gggatgcttc attatctcct 2914081 tacattttga ccgtaaaaga ctttgatagt ccatcaaacc gcctccctac taaattaaat 2914141 gaaggaaagc aaaaaaaagt aaactactac tttccgccta gtgtcttcca aaatactttg 2914201 cagcagttta cgttttatcg gttttcctca cttacataca tgactgcaga aaaagaaggg 2914261 aggtattttc ctatggatca ggtttttata gaggaagtcg taaaacagat cggcaatttg 2914321 gggtttcccg cgctgattgc aatgtatctg ctgacccgat tcgaaaagaa gtttgatcaa 2914381 ctaatagaac taatgacaga actgaaagat catgcaaaaa aataattttt caatcgaagt 2914441 tgacttttca ctggtttttt tcacttaaca aaacagaagg gaaaacgaaa ggcctttcac 2914501 cttctctttc tgctatcaca tttaaatgta aggaggaaac atttcatgaa aaaacaaaat 2914561 gacattccgc agccaattag aggagacaaa ggagcaacgg taaaaatccc gcgcaatatt 2914621 gaaagagacc ggcaaaaccc tgatatgctc gttccgcctg aaaccgatca tggcaccgtc 2914681 agcaatatga agttttcatt ctctgatact cataaccgat tagaaaaagg cggatatgcc 2914741 cgggaagtga cagtacgtga attgccgatt tcagaaaacc ttgcatccgt aaatatgcgg 2914801 ctgaagccag gcgcgattcg cgagcttcac tggcataaag aagctgaatg ggcttatatg 2914861 atttacggaa gtgcaagagt cacaattgta gatgaaaaag ggcgcagctt tattgacgat 2914921 gtaggtgaag gagacctttg gtacttcccg tcaggcctgc cgcactccat ccaagcgctg 2914981 gaggagggag ctgagttcct gctcgtgttt gacgatggat cattctctga aaacagcacg 2915041 ttccagctga cagattggct ggcccacact ccaaaagaag tcattgctgc gaacttcggc 2915101 gtgacaaaag aagagatttc caatttgcct ggcaaagaaa aatatatatt tgaaaaccaa 2915161 cttcctggca gtttaaaaga tgatattgtg gaagggccga atggcgaagt gccttatcca 2915221 tttacttacc gccttcttga acaagagccg atcgaatctg agggaggaaa agtatacatt 2915281 gcagattcga caaacttcaa agtgtctaaa accatcgcat cagcgctcgt aacagtagaa 2915341 cccggcgcca tgagagaact gcactggcac ccgaataccc acgaatggca atactacatc 2915401 tccggtaaag ctagaatgac cgtttttgca tctgacggcc atgccagaac gtttaattac 2915461 caagccggtg atgtcggata tgtaccattt gcaatgggtc attacgttga aaacatcggg 2915521 gatgaaccgc ttgtcttttt agaaatcttc aaagacgacc attatgctga tgtatcttta 2915581 aaccaatggc ttgccatgct tcctgaaaca tttgttcaag cgcaccttga cttgggcaaa 2915641 gactttactg atgtgctttc aaaagaaaag cacccagtag tgaaaaagaa atgcagtaaa 2915701 taaaagactt gcggcttgca gagagcactc gttctctgca agccttcata aggagctgaa 2915761 ccagtgaaac atcaaaaccc ttcaaaacgc ttattgcggc tctccataaa gtacttgctg 2915821 gccgcagcag cagtggtgtt gacctatttt gctgtcatct atatattgtt ttctttagcg 2915881 ggaacgagct accgctcagc agctcatgtc ctgctttttg ccgtggtatt ccttgttctc 2915941 ggattatgct ttgaaccatt tgaacggctg atgatacata gctttacatt tttcaagaca 2916001 ggaaaacgtc tattcattct ccttgctggc atcgtacagc tgctgttttt gtggatgact 2916061 gctcatacaa cagaccaatt gatcagcgac atctggctgt ccaccacaga agaaatgatt 2916121 gtcgcagccg tttttttgat tttagacaaa tgcaactcgg ctcttcccag ctaaaaaaag 2916181 aacgcattcc aattggatgc gttcttttta ttcatagcga agcgcgtcta caggctgaag 2916241 cttcgaagcc ttgatagacg gaagcaagcc gaagataatg ccgactgcca ttgaaaagat 2916301 gagtgctccg acaacagctg gaatggagac gataaaaggc atcggaaaaa tgaccgtcag 2916361 cagcttggcg atgccgaagc ccgccagcac accgagtatt ccgccaatgc ttgtcagcac 2916421 gacagcctcg gttaaaaatt gaaataaaat cacacgccgc ttagcaccga gcgctttctt 2916481 aattccgatt tccctcgtgc gctccgttac ggaaacgagc ataatgttca tgacgccgat 2916541 accgcccacc aaaagtgaaa tactggcgat accgccaagc agcaatgcaa atgactgatt 2916601 aaaggactcc acttcctgcg cgatctcctg aagatccatt acactgtact ctgctttttc 2916661 cagctcagct tctgacagtc cctgatttaa aagatctgca gccattacac ccgcttcttg 2916721 gatatgctca gaagaatcag cctgcacggc aatctgcgtt ggcgcgtcaa atccttcaat 2916781 aagcggccac acttttttcg gcacgtacaa aaccgggttc gcatagtcgc cttcaaacat 2916841 gctttcctgt tgattttttt ctttaaaaac acccacgacc ttaaacggca caccattcat 2916901 ctcaatgctt ttatgcagag cttctccgtc tggaaacagt tcatctctga cagcttcatt 2916961 gatcatcact acttggtgtg tgctgtttaa atcgttttcc gtcagctttc tcccttcggt 2917021 tattcggatt ggaaacatgt cgaagtaatc atcgtccact ccatacactt ggggatacga 2917081 aacgttagtt aaatgaaaaa cgctcgcgcc ttctgacaag taatataagg ataatccttt 2917141 gaccatcgga tctgatttga tcgcctttac tgtttcttcc gctacaggcg gcgcggacgc 2917201 atacgacacc tgagggccgc cgctctcctc ttctccgcca gacggctggt agacaacatt 2917261 gatggcgttg tttcccatgc cgatcatact ttgctttaac tgctcacttt ggcccttcag 2917321 cattgaaaca atcgcgatga ttgccgctat gccgataatg acgccaagca ttgtcagaat 2917381 cgatcttaat ttatgagaga aaatggattg aaaggagatt cgaatatgtt caagcatggc 2917441 tgatatcccc tctctcatct aataccaact ctccgtctct gataaaaacg gttctgtcag 2917501 cttttttggc gacgtccggg tcgtgggtta tcataataat ggtcttgcct tcccgatgca 2917561 gttcagaaaa cagtgccaaa atttgttcac ttgatttggt atcaagcgcc ccggtcggtt 2917621 catcagctaa aataaacctc ggctgattga caagggccct cgctatcgcc acccgctgct 2917681 tttggccgcc ggacagctta ggcggtttgt aggagaccct gtcttttaat ccgacttttt 2917741 ccagcgcttc atatgcccgt tgccttctct cttttttctt cactttattg tagatcatcg 2917801 gcagctcgac attttgcagc gcggtgagac gcggcagcaa atgaaaagtt tgaaacacaa 2917861 acccgattga ttcattgcga atttcggcta aagccccgtc tttccctttc aatatatcga 2917921 tctggtcaag cgtataggtt cctgaggttg gcctgtccaa acagccgata atattcatta 2917981 acgttgactt tccagaaccg gaaggcccca taatagctaa aaactccccc gcctgaacgg 2918041 tcagattgat atgtttcaag attggaactt cttcttttcc cagcttgtac gacttcgaaa 2918101 tattattcag tgtcagcatt gactgtaacc tgctttcctt ccttgaccgc gggatcagga 2918161 tagatcacat aatcttccgg cgtcaggccg ctcttaattt ccaccatgtc attttcatca 2918221 gtctctccga tttcaacagg ctgcttaacc gctttgtgat tctcatcagc tttccatacg 2918281 tacggttcgc cgtcatcctg aatgaccatg tcggacggca gcttgatcgt gtccgcatca 2918341 gcattatcac tcatcacttc gatgttgaca tgatagccga cttcaagacc tttatggctg 2918401 tctaataaaa tggtgaaagg atagttagag gactggggat tcatttcttc atcagcaaag 2918461 ctttctgatt cttcaccctc gcctgctccc gctggaagct tgccgatcga ggtgaccttt 2918521 cctttccact cgccctcacc gcctgttttc agcgtgaccc tgactttgct gccttttttg 2918581 atcgtgtcca ttaacagctc attgatttgg cttttgacca gatatttgcc tgtcgaaaca 2918641 atctggatat acgggcctgc tgcctggtcg cctgttgcac cgtcagcgat atcctgattg 2918701 acgctttgaa cgattccgtc atgcttgctt gtaatgacat tggaaccttt gtttttcgtc 2918761 aggccagcca gttctttttg atgctgcttc agttcaagct ggcttgtttt caaatcgaaa 2918821 ttggtttgat caagttcatc ttgaagctgg tttttctctt cttttcctgc aactttcagc 2918881 tttttttccg tttccgttat tgatttttgc aaacggttga tttgcagatt tgtcatttca 2918941 atttgcaaat tggcttgctc cacttcatca gaatgatcct cgccctcata ctcaaaaagc 2919001 ttatcgccct ttttaacctg atcgccttct ttgacgtatg tttttttaat gctgcctttt 2919061 tctgaatcta tgtatacttt ctgctgtttc tcaggttcaa cctttccaga aaacgtttgg 2919121 cctgattctg aatctcctcc catgtatacc gcgaccgatt cagcataggg ctccgatgat 2919181 acggcaactt ggttcatgtg agtaaaaaag taaaaaccgc cagcgccgat cccagccaat 2919241 acaagcacac cggcacatat cgcaccgcca ataagccatt ttttcttctt ggacacaacg 2919301 atctcctctt tctgtaaact atgtaatatt ttcgaaacat tctaaccaat attatctatt 2919361 aattcaaaaa gacttgcaat ccttttattg aaatgacgga atcaaataga aaaattgtat 2919421 tttcaaagcc gaataaaaaa aatcccggct tcaaaccggg attttttcat acagtaacta 2919481 gctctttttc atttttaatc aagtcatatg tcaagcatac aggtttattt gtacggggat 2919541 cagtcacgat ttcggcatca atctgaaata cctgcttcaa aatgtctggt gtcatgacct 2919601 ccagagcagt tccttccttg atgaccgtgc cttttttgag cgcgatcata taatgagaaa 2919661 aacgagctgc atggttaaga tcatgaatga ccattaaaat cgtccgccct tgctctttgt 2919721 tgagtctgtc aagcagctgc agaatttcaa gctgatgtgc aagatcaaga tacgttgtag 2919781 gttcatccag cagaagcagt tccgtccctt gcgcaagcgc catggcaatc cacacacgtt 2919841 gacgctgtcc gcctgacaat gcctcaatcg gccgttcagc atattcagcc atgcctgttt 2919901 cttcaagcgc ccatttgata atccggcggt cttcgtcatt taatctgccg aatcctgatt 2919961 gatgcggaaa cctgccgtac gacaccaatt cgtgcactgt taggccgctc ggcgcttcag 2920021 gtgtctgtgg aagaatcgcc atatcttttg caatgtcctt tgtagacatt ttatgaatcg 2920081 ctttgccgtt taaatagacg gcacctgcat gtgaacgcat aattctggac attgttttta 2920141 aaatcgttga tttcccgcag ccgttcgggc caattaaggt ggtaattttc cctttaggaa 2920201 tcgatatatt taaatcctct acaatcaccc tgtcgccata accgattcca agctgttccg 2920261 ttgataatga attcatattc ggccccctcc tctaattcgc tttcatcaat aaataaataa 2920321 agtaaggcgc acctagcacg gaaatgacaa gtccgaccgg aatttctgat ggtgccaata 2920381 catttctcgc cagcgtatca gcaagcaaaa acaggaatga gccgatgaag gcggagaccg 2920441 gtatcagcgt ctggtgacgt ggaccggtca gccttctagc cacatgcggc gcgatcaatc 2920501 cgagaaacgc aatgcccccc gcagctgcca cgcatgaagc ggcaagagtg accgctgcca 2920561 gaagaagaat ccgtctttcc ttttcaacag cggtgcccag cccggtcgcc aattggtctc 2920621 cgagctgcat aatgttcaaa tagcgtgcct tatataaagt aaacagaagc aagatcacaa 2920681 tccaagggag aatcgcccag atcatattcc agttcgcccc ccatattgag ccggatatcc 2920741 aaaccgcggc ttgcataaaa tcatgagggt ccatcttgag ctgaaaaatc agcaacaggg 2920801 cgttgaatcc ggcattcacc cctatgccga ctaaaatcag ccgaatcggt gtcacgcctt 2920861 ttttccatgc cagaatataa atgagaaacg cagcgaggat tgctcctgcc aaagcactga 2920921 acggcagcat aaatgttccg aaaaagctaa gatctgaagc tgacccttga aaaaagtata 2920981 taaaaagcac tacagcaagt gaaccgccgg cgttaattcc gagaatacca ggctcggcaa 2921041 gttcattttg agacacgctt tgcaaaatgg ctccagctac ggagatccct gctccaacaa 2921101 gcaaagaaag gatgatccgg ggcagcctga actcaaataa gacaagttca tcacgcgccg 2921161 ttccttggcc gaaaaagacc tgaagcgttt taagcggtgc aattttgata acgcccaaat 2921221 tgagactgat aaaaaagacc accacgataa gcaaaaaggt cacagccatt acaatgagcg 2921281 gtttgtttgt ttttgttttc attacagccc tctcctttca cgacgtgcca aataaaagaa 2921341 aaagggaacg ccgataagag aagtcagcgc gccgacaggc gtttcaaagg gcgcatttac 2921401 gagtctggcc gctatgtcag caaaaacaag caaaacagca ccgagcaccg ccgagcaagg 2921461 aatgatccac cgataatcca caccgaccaa aaaacgggta atatgcggaa tgatcagccc 2921521 gataaatgca atggtgccgg caatggaaac cgcagctccg gtcagaatta ctacaataag 2921581 catgccaacc agtttcaccg ctgatgtata ttgtccaagc ccttttgcca gatcgtcacc 2921641 gagacttaac actgtaacag accgggcgat gaaaaacgcg agcgttaaac cgacagcccc 2921701 tgcaataagc aaaagctgga cccccgacca tttcacaccc gctaccccgc ctgcgtacca 2921761 aaagctgata tcctgagcga catcaaagcg gattgcaatg gcagttgaaa tgccggtaaa 2921821 gaaataagta actgccgtac ccgccagagc aagctttaca ggcgtaagtc cgccccttga 2921881 aaacatgcct atgcccatta ccgtcgatgc ccccagcccc gctcccgcaa aggaccatag 2921941 cacaagcccc attgcagaaa gtccgggaaa aaaggcaaac gcaatcgaaa ccgcaaacgc 2922001 agagcctgat gtcacaccca taatcgaagg ctctgccaaa gggtttctcg tcatcccctg 2922061 catgattgct cccgacactg ccaacaatgc gcctacaagc gcggcagccg ccgttctcgg 2922121 aagccgaaga tcatgtataa tttggtgaga tgtctttgtc ggctgataat gaaaaatggc 2922181 ctcccataca gtgcgcaaat gaatatccgc tgcacctagg gatatggata aaaatgcgcc 2922241 aaggcaaagc aggcatagac ctgcgataag gacgatgacc gcgccatatg tccttgacgt 2922301 ccattggatt tcttctgatg cagtccgtat atttttatgt tgactcaact gccgtacttc 2922361 ctttctgtta ctgataatga ttatcaattg ctgtttcagt atatcacttt tttcagctga 2922421 tttaatagag tgttttgaac aaaaatgaaa atgcatttgc aaaaatatcg tgtcaaccgg 2922481 cacttgcagt ggtataatca cagatgataa tgattctctt tttcatctat cttttagaaa 2922541 gaaggtatga gatatgaccc atatatacaa gaaactcgga gccgcgtttt ttgccctgtt 2922601 attgattgca gcgctggcag cctgcgggaa taactcagaa agcaaaggtt ctgcctctga 2922661 ttcaaaaggc gcagaaacct ttacatacaa ggctgaaaac ggaaatgtaa aaatcccgaa 2922721 gcatcctaaa cgggtggttg tcatggcaga cggctattac ggctacttca aaacactcgg 2922781 catcaacgtt gtaggtgcgc ctgagaatgt atttaaaaac ccttactaca aaggaaaaac 2922841 caacggcgtc gaaaacatcg gagacggcac ttcggttgaa aaggtcattg atttgaaccc 2922901 tgacctgatt atcgtctgga caacacaggg cgctgatatt aaaaagcttg aaaaaattgc 2922961 gccgactgtc gcagtaaaat acgataagct cgacaacatc gaacagctga aagaatttgc 2923021 aaaaatgacg ggaactgaag ataaagctga aaaatggctg gccaagtggg ataaaaaagt 2923081 tgcggccgct aaaacaaaaa tcaaaaaagc ggtcggtgac aaaaccattt ccattatgca 2923141 aacgaacgga aaagacattt acgtatttgg taaagacttt ggaagaggcg gaagcatcat 2923201 ttacaaagac ctcggcctgc aggctacaaa gctgacaaaa gaaaaagcca ttgaccaggg 2923261 gccaggttat acaagtattt cattagagaa gctccctgac ttcgccggag attacatttt 2923321 cgcgggccca tggcaatcag gcggtgatga tggcggcgtt tttgaaagct ccatttggaa 2923381 gaacctgaat gccgttaaaa atggccatgt atacaagatg gatccgatcg gattctattt 2923441 cacagacccg atttcattag aaggacaact ggagtttatt acggaaagct tgactaaata 2923501 aacaaaagag ccgcctgccc gcggctcttt tgcttattta taaggaacgg ctcaatttga 2923561 atcatatcgg atattttctt tgagccattc atattaagct gcatcctcat cacgatcagt 2923621 ttttttatgc tggagagact gaaaaacgtt ttttgcatat ttaacgaacg gattcctaac 2923681 aggagaaatt gtgattttat aaaaaagaca cctgagcaaa tcaggtgtct tttcattatg 2923741 cttgtttttc tttctggaac ttgttactca caaatggata aacgattaag ccgacaaaga 2923801 ataaaccgat gccgagtata aatgtcgtta aatctgctgt gcctgttacg ataacaaaca 2923861 cggagtatgc acacgccagt atcgcgatca atccgtctct tacacgggag cctttcagct 2923921 ggtcatacgt ttcacctttg atgactacct tcaagctgta gattgcagat accagatacg 2923981 gaattaaata tgcgagtgta gccgctgtcg ttaaaaatgt aaatgcgtca cttattgtcc 2924041 gggaaataac cgagaaaatg aagacctgtg acatgacgtt tgtaataatg agtgcaatga 2924101 ccggacttcc ctttttattc gtttttgcaa aaaatgccgg gaaatctcct gctttagcgg 2924161 cttggtatgg cacctcagag ccaagcaaaa tccagccgag catcgttccg aataaacaaa 2924221 ggatagccaa aagcgccata atcacgcttc ccgcgtttcc aacaatcgca tagagtacat 2924281 caacaaatgg tttttcagag ccgacaagct tatcatgcgg cagaacaccc atcgtaatta 2924341 aagtcacaat aatatatatg ctcaaggcaa tcagcaagcc ggtaattgtc gcacgtttca 2924401 catcacgctg agagcgcgca cggccggaca ggatcaccgc ggattcaatt ccgacaaacg 2924461 cccacagtgt agaaatcgca gcgttatgaa cctggccacc aattccaatg cttgtgccgt 2924521 tttctccttg aaccgggaaa taaaaatgac cgaataatga cgtttgaaac acaaacaaac 2924581 cggcaacgat aaagaagaca aaacctaata ctttagaaag cgttgtgaca aagtttaatt 2924641 tacttgcgcc gttaatgctg gcaacaagaa tcgcgtgcgt tccccataac aagatcgtac 2924701 atacggcaaa cgtcagtaat tggccgagtg tcacctcttg cccgccgatc gaaaacatct 2924761 cacgtttatc aaccaagatc gggaagaacg aagtcaagta accggcgaga cttgtgatga 2924821 tcgccacgtt actgatccag ctcgccaccc agtagcccca caccattgtg aaaccggcag 2924881 cgttgccttt tttcgggtca gaaaacagcg ctcttgcata actttgcggt cccgctgtca 2924941 gttcaggctt gcgaatggac aagtgtccga acacaagtgc aatcatcagc acgccggcac 2925001 ctgtcaaaag ccaggcggac gtagctccaa acggactcgc aattgaagca agcgagctcg 2925061 gcaaggagaa aattcctgat ccaaccatat ttccaacgac aaacgccgtt aataaccaaa 2925121 aaccccattt ttttgtctgt tccattccag tacctccatg attctttgta cggaccagac 2925181 cccgagatca tataaacgca aaaaaagcct gaacaaaagt ccatgcttaa agaaacacac 2925241 acccttgatc tccggatagc cctccgcgaa aaagcacgcg gcagtcctgc acttattcag 2925301 atacagtccc agcatagaga aggatcggct ttctccacac ttcggcgctg atgcctttta 2925361 cacatgttta acagcccctg tcagcctagc atgtgtgact catcatccgc gcaacctcta 2925421 cctcactgag aaagagtgag gatttaatta ttcagttact cccagaaggt tatcaaagaa 2925481 aggatgatct gtcaaaggga acagatggaa aatacggata gagccaagcc ctatccgcat 2925541 gtggttatcg attatttttc tttttttgca cagcttcttg aagcggatca tcttttagag 2925601 ctgaaccagc atcttcaaga gctccttgga ttacgttttt ttctttttcg gaacgttttc 2925661 ctttatcttt attaaagaaa cccattcgta tcacctcttt taaaaaatag gtacatgttt 2925721 aagatgcctt tttcctgaaa aattatgcgg gatatttttt atcgtccaaa gtcctgttga 2925781 tcaaacatac attctcttga tatatttgta attcagagat tttttgcaaa agataaaagg 2925841 agaagcggca aatgacagga aaaacacaca tcatgggagg catcgcttct tgtacggcag 2925901 cggcttatta ttatggattt gatccagtgc ttatggctgc gtcaggcgcg gttggagcat 2925961 taatacccga tatctgccac acacaaagca aaatcgggag aaaatttcct attttatcga 2926021 aagtggtcag ctccgttttt ggccatcgca cctttacaca cagcctgctg tttatgctca 2926081 tcatgttttt tatcacttct acatacattc cagataaaaa catatcagcc ggcctgatga 2926141 tcggaatggc gagccacttg attcttgacg cttggacggt gaacggaatc aaattattat 2926201 tcccttccac gatccgcgtt cggcttccat tatatatgaa gacaggcagt ttttctgagc 2926261 agctcgtgct agccggcctg acccttgctt catgttacta cttttatatg ctgtttcatg 2926321 gccgcatgtt ttaaacatga gtgctgagac ttgtctgaac cggctgtttt tagtaggttt 2926381 tacttaagaa gcatttcatg cagatgatca agaaaacgtg aggagtcata ttgatgaaag 2926441 gaaccttttt tcacaatcag cggtttttat gtttttcgat cttatttatg tggatcaaaa 2926501 cgtatgtgat atataaactc ggctttgatt tgcaaatcga tactctgttg gaggagctaa 2926561 tgctgctggt caacccgctc agctttattc ttcctttatt cgggatcggc ctgtttctaa 2926621 aagaaaacaa gcagcgggcc tttttgctga ttgccaattt ggttctgact gttatcttga 2926681 tctctaatac gattttttac ggcttttata tcgattttat taccatcccg gttttatttc 2926741 aggccagcaa catgagcgat atgggcagca gtgtaaaaga actgttccat cctctgttta 2926801 tcgccctgtt tgtggatttg gtttttctgc tgttgttcgc cagaaaaacc aaacacccac 2926861 agacaaaagc cgctccccac acgatcaaac ggtactatgc agcttcctgc ggaatgcttt 2926921 tatgcacact ggcacttgca gaagtacagc agccgaagct tttggcacat tcttttgacc 2926981 gggaaatgct agtcaaaagc atcggcctgt ttcagttcca tatttacgat acaatttctc 2927041 agactgttaa tatcagcgcg aaagcttttg ccgatgaaga cagtataact gccattaaaa 2927101 actacacaga ggctgattac agcaagcctg atcaaagcaa attcggtctt gcaaaggggc 2927161 gcaatgtcat ctttgtaaca cttgagtcga cccaaagctt tgttctgaat gaaaaagtaa 2927221 atggaaaaga aattacccca tttatgaatg atctcataaa aaaaagctat tcctttgatc 2927281 atttctatca gcaaacagaa caaggcaaaa catcagattc agaatttatc gtcgctaact 2927341 cactgtatcc ctcccttagc ggcgccgtct ttttcacgaa aagcgaccat caatttcata 2927401 cgatgtataa atcgctgaag cagcacgatt attattcagc cgtctttcac gctaaccata 2927461 aaacattttg gaacagagat gtcatgtacg atacatttgg cattgaccgc ttttttgatg 2927521 ttgatgattt tcatgtcact cccgggacat cgacaagctg gggcttaaaa gacaaagaat 2927581 ttttagagca gtccgccaaa aagctgaaaa gcctaccgca gccgttctac agcagtttta 2927641 tcacgttaac gaatcatttt ccgtttgaga ttgatgaaaa ggatcagctg atagatgaat 2927701 tcgattcaag cagtgatctg ttaaaccgct atgtgaccac ggttcgctat gaggatgaag 2927761 cattgaagca ttttatcaaa aaactgaagg acgaaggctt atacgaaaat tcgatgatcg 2927821 tatttatggg agatcattac ggcatttctg aagcccataa cgaggcaatg gctgagtttt 2927881 tagggaaaga cgaaatcaca ccgtatgaca acgttcagct ccagcgggtg ccgtttatca 2927941 tacatatccc gggaatcacc gatcaacagc cggaaaccat ccctgatgcc gggggacagg 2928001 tcgacgtcag gccgacgctg atgcatttgc tcggcgttga gacaaaaggc gatatccaat 2928061 tcggcaatga tttgctgtcg ggcgaccgca ccccattcgc cgttctgcga aacggcagct 2928121 ttattacgaa cgattatgta tacacaaaga acacgtgcta tagccaaaaa acaggtgaag 2928181 tgctggaaga tcaggatgcg tgcctccctt acaaggagaa agcaaacgaa gaactgtctc 2928241 tctctgataa aattttaaat ggtgacctgc tcaggttttc cgaatgaaaa aatccctcta 2928301 tcaagaggga ttttttacgt ttccaatatc accttgccag tcagcttcgt ttcatagccg 2928361 tttaaatgag acagattcgc cttgtagtcc tcagaattca aaatctcctt cacggctttg 2928421 agcaactgct catttttttt caaaacaacg atatcatatt gttcgtcgat gagcgggata 2928481 aaatcaacac tgcccatatg tgccgcgtgc tgtgccccga ttcccgcgtc agcctgtccg 2928541 cttgaaactt gtgaagcggc agcgtaatga tcagtcacga tatcgccata tcccactaca 2928601 tcagccggat tcacaccaag caagccaagc tgttcatcaa ggagcaccct tgcgccagaa 2928661 cccttttccc tgttgatgat ccggatatcg gctcttttca agtctttcca gccttgaatg 2928721 tttttcggat tccctttttg cacatacagt cctgctttgc ggagaacgac attgatgaga 2928781 caaaacggtt cacctgtcaa aatccgtttt acataaggcg cgttatactg gcccgtttct 2928841 gcatcgtaca aatggaggct gacaatgtca cacttgcctt gatacatatc aatcaggctg 2928901 tttaagcttc ctttgtattt acggagcggc gtctcctgaa tggcattctc caaatgcttg 2928961 ctgaggatat ccatcgaaat gtcctgtccg ctgatcatga catttggtct gccgtccggc 2929021 tcagcctcct gcacctgttt cggcgcttct tttgcagcga tgggctgaga cattctcata 2929081 ttcgttttat attgctttaa atcttcttca tccacacgca tctgccttcc gacacggtaa 2929141 gcaggcagca cgcctttttt aatcaagtca taaacggtca gctttgatac cttcagcaga 2929201 cctgcaactt cttctatcgt ataggaagag gtttcattca tcatcatcac tctcctattt 2929261 tattatacct tttcgccgaa tgtaaaaaaa cccacataaa ccaaacataa tcagttataa 2929321 ttagttatat ctaatgataa ggggtgcaat catgtttaag aagtattcta ttttcatcgc 2929381 agccttaact gcttttctgc ttgtagcagg ctgttcttca aaccagtctt caacggacag 2929441 cgagaaaaaa gtaacgttaa ccatctcagc tgccgccagc gcgcaggatg cacttgagga 2929501 aatccaaaaa aattatgaaa aagatcatca acatataacc atccaagata actatggctc 2929561 atccggcgcc ttgcaaaaac agatttctca aggagcagga gcagatctgt tcttctcagc 2929621 tgctgaggat aaatttaaaa agctggtgga tgatggagat atcgcaaaaa aagacagcac 2929681 tgaattagtc ggtaatgaaa ttgtgctggt cgtaccgaaa aacggagatt cacctgtgac 2929741 aagcttcagc aatctggctg aatcagaaaa aatcgctctt ggcactccgg aatccgtacc 2929801 ggcaggagct tatgggaaag aatcactgac aaagctgtct ttatgggaca aagtgaagga 2929861 taaaattgtg tatggaaaag acgttcgcca agttctttct tatgttgaaa ccggcaatgt 2929921 agacgcaggt gttgtttata aaacagatgc cctagtctcg aaaaaggtca acattgttga 2929981 cgaggcaaaa gcagatacac acagcccaat tgtctatccg ttaggaatcg taaaagatac 2930041 aaaacaccgt aaggaagcga aggaatttta cgaatacctg caatctgatg aagcaatgaa 2930101 agtatttgag aaatatggct ttactgccga gtagcataag cgcttcagaa tttttcacac 2930161 ccgttgtgct ttcctttcag gtggcggcag ttgccggaat tgttgtcatt attctcggaa 2930221 cacttgctgg agcatggatg tcacgggcat catttttcgg aaaaacggca ctcgaaacat 2930281 gttttatgct tccgctcgtt cttccgccta ctgttgtcgg ttttattctg atcgtcattt 2930341 tcggaaagca cagcttcatc ggacaagcca tcgagtggat tttccagcag cctgtcattt 2930401 tcacctggtg ggccgctgtg atcgcctcgg ctgttgtagc ctttccgctt atgtatcaat 2930461 cagccaaaac cggatttgct gacattgatc ccgatataca aggtgcggca atggtagacg 2930521 gcgctagcag atggaaagtg tttatccata tctccgtccc gcttgcctat ccttcgttac 2930581 tgaccggaag catccttagc cttgcgcggg cgctcggaga atttggcgca acactcatgt 2930641 ttgcaggaaa catccccggt gttacgcaaa cactgccgac ggcgatatat gtcgcattgg 2930701 attccggcaa caataccctt gcttgggcgt gggtcgtctg tattgttgtc atttcctttt 2930761 tgatgctgtt tttcattcaa cagaaaaaaa cgcactaaaa aaactcccca taacggggag 2930821 ttttttgatt aaaacagaag ctcatcagga tttggaccga cacgctcatc tttatttaat 2930881 gcgtcaattt tgtccatgtc ttcttgagac aattcgaaat caaaaatatc agcgttttcg 2930941 atgatacggt gttctttaat ggattttgga atggttacaa ctccatgctg cagatcccag 2931001 cgcaaaatca cttgagccac agatttattg tgtttttcag caatctgtgt cagtacttcg 2931061 ttatccaaaa gctgtccctg catgagcgga gaccacgctt ccagctgaat gccttgccct 2931121 ttgcagtaat ctcttaattc tttttgcgtc aagcgagggt gaaattcaac ttggttcacc 2931181 atcggtttga tttcagcatc tttcaacagc tcttctaaat gatgaacttg gaaattgctg 2931241 acgccgatcg cgcgaatttt gccgtctttg tacagctttt caagcgcgcg ccatgtatct 2931301 ttatatttat ctttgccagg ccaatggatc aaatataaat ctaagtaatc aagctgcagt 2931361 ctttctaggc ttttttcaaa ggcagcaagc gttgtttcat agccttgatc ttcattccac 2931421 acttttgatg tgatgaagag ctcttctctt gccacaccgg attctttaat cccgatgcca 2931481 acgccttctt catttttgta gatcgctgct gtatcaatac tgcgatagcc atttttaatt 2931541 gccgctttca ctgattcagt cgcttcatta ccattttcta ctttaaaaac gcccagaccg 2931601 aaccaaggca tttcaactcc gttatgtaac tttacagtat cttttaaact tgttggcact 2931661 tgaacctcca ccctttcact gaaatgtaag cgtctatatt atctcacatt cctctcagcc 2931721 gataccaata atacgcttaa gaccctcttt ttgcttcttt tttcacagca caggcaaatc 2931781 caaacactat ttttttccta ttttaacaat attgagatta caaatacatt gagcagggta 2931841 tgcgtgtagt gtaaccaaat gaaaacaaag gaggaaacaa cttgaaacgt attcgtatcc 2931901 caatgacact tgctcttggt gccgctttga caattgcccc tttgtccttt gcttccgctg 2931961 aagaaaatcc tgctccgaag atgtcgcaga caactactgc tggaacaact gccgctgatg 2932021 taggtttaaa cgtcaacctg gatgtacttg gaattgccaa ccagatcgct gatgccatca 2932081 aatccgcaca gaatagggat ggctttgtga aaaacctcat ggagtcttcc ttctacgcgt 2932141 ccggccaaaa atataacgtc atggtcttta atttaagcca ggaatatgaa gatcatttga 2932201 acggtgtgca attttacggc tcagccgttt acgacggcat tacgtatggc atttgggtat 2932261 ttgaagatgg aacctttaca aacaaaggcg atggcggctg gatcaactgg gccttcagag 2932321 gctggttcga ccgggatggc agcactgtcg catttcatcg cccttaatat aaaaaaagct 2932381 ggcgctctaa cgccagcttt ttttctgcat ttattcgccg ccttcaagca tggcggcttc 2932441 gacatcatta atgtattggc gaagctcatg ggagatgtcc cgggaaattt ccctctcttc 2932501 gaagagcgtt tgaatttcat ttctgatcgc ctgcacagcc ttcagcttca cttccagctt 2932561 ctgattttca aaatgggcac ttgattttaa ctcatgatgg ctgtgctcca gcctgaaaat 2932621 taactgctta tagaatgtaa tgacagataa aaacacttct ttatgctcat ccgtcttatg 2932681 tttttccaga tattctatcg ctgcttttgc cgttttcact cttgttgccc gtatcaatcc 2932741 cgcttcattt aaaatcgaca tctccggctt tttatgttca ccgaagaaaa tccaatacat 2932801 cagcctcttg agccttgttt ttgataaccc gactttaaac gggttggcat acaaaatttc 2932861 caactcgtta aatcgttctt gcagcacatt tgctgtttct tccgggatgt ctccccgctc 2932921 cagcattttc atcagcgcct cttgctcagc cttaaccccc tgcgcacgga cttttcgctc 2932981 gtgcttctta atgcgattag atgatgtata ctgctgaaaa cgaagatttt tcattttctc 2933041 attgtattca gctatcaccg caagagaggc cgttttgttt gtctcattca tgtcctcttt 2933101 aatcgtttga agggctgttt tgatcaactt gcgtctcgcc gtcagcagct tcttatttcg 2933161 ttcctcgtcc tcttcttctt tttcagtcag aattggcagc acaacggtgg caatgacaag 2933221 cgtgcataaa atgacgccgg ctgctaaaaa gagaatcaga tttctttccg gaaacggcgt 2933281 accgtcctcc aggaaatacg gaatggaaaa agaacctgca agcgttactg ctccacgcac 2933341 accggaaatc gaaattaaca gcgtcgaacg aagacccggt ttatagatgt tctgatcttt 2933401 attaaagaac catttgccgt tccagaagaa cagcacccac aggaatctaa ggagcattaa 2933461 tgtaaatgtg atgactagga tatagccgat caccttcatg ttgctgatgg cagtgtcgtt 2933521 aaagataaca gaaataacat cagggatttg cgtgccgaga ataacgaaga ccaggccgtt 2933581 caaaataaat aaaataatgt tccacgtact tgaggagacg atttgcagct tgatcatcgt 2933641 tgattccaga cgatcctgtt caaccgcatg ggtaataccg ccagctacaa cagctaaaat 2933701 gcccgaaacg ccgatttctt cagctgccaa ataaatcaca aacggcgtca gaatttgaat 2933761 cagcatatgc atcgtgacat cctgcatgcc aaggcggcgc agaaataggc gaaaacgaat 2933821 aatcaaaaat gaaatgacaa ccccgcacag caagcctccg agagaaataa agacaaagct 2933881 gacagccgct tgtgctaatg aaaatgcacc agtcactgcc gctgcaatcg caaacttaaa 2933941 ggccaccaga cctgatgcat cattcatcag cccctcacct tccagcaggc gaagaatccc 2934001 ttttggcatt ttcactcttc ctgataatgc gctgacagcg acgacatcag tcggtgaaag 2934061 aatggccgca agtccaaagg ccgctgccag cggaatagca ggaatcatcc agtgaatcgt 2934121 gtagccgcct acaatcacag tcgcaaatac aaggccgagt gcaagcaata aaatcggagc 2934181 ccttaaattc caaagctctg cccgcggtgt cctctttcca tcattaaata gcagaggcgc 2934241 gataaaaaga acaaaaaaca attcggtgtt taattcaaaa tgaagtccct gtggaaatga 2934301 ggcggcaaga atcccaagag ccacttgaat cagcggcacc ggaataaacg gaataaaccg 2934361 gttcacgata ttagaaatcg caataatcgt taataatacg agcacaacta aaaatatgtc 2934421 caaatgcatg acctccttcg tctgttgtgt gtcggcatga tgagccaaaa aatctgtttg 2934481 tctaaaagcc cttgagctag ggtggccttg catccgctat gtggtttcgc aggagttctc 2934541 tccacacttg tcttctttta tagtaccctt tttagggtat tttttctcat gatatgctca 2934601 cagtgaactt ttttgcagaa gagcaaatta tagaaaaaag agacaggaag ctactccctg 2934661 tctctcgtct ttctttctca atcatgaaaa ttcgtaccgt cagttgttgc tttaataatg 2934721 cccgcgcgaa tgacaaagtc accgaaatgc tcgccttcct cgcgttcttt cgcatagcgg 2934781 gaaagaagga tgcgcagctc gcttaaaatg tctgcttcac cgatgttttc acggtacatt 2934841 ttgcttaaac ggcttccgtc aaacgcagcg ccaagataca tattatattt gcccggcgcc 2934901 tttccgataa atccgatctc accgagtgca tgacgtgcac agccgttcgg gcatcctgtc 2934961 atgcgaatgg tgatttcctg atcacgaagg ccgttttcgt caataatctc ttcaatctta 2935021 tctaacaggg tcggcaaata acgttctgct tcagccattg ccaatccgca ggtcggaaga 2935081 gcgacgcacg ccatcgagct gcggcgaagc gctgaatagt gcttgccgtc agttagtccg 2935141 tactgttcaa ttaaagcact gatttcttct tttttatcgc ttgaaacgtt cgcaatcatt 2935201 aagttctgat tggctgtcag ccggaactca cctgtatgaa ctttggcgat ttcccgcaag 2935261 ccagtcatca gcttataatc atcgtaatcc gttatacggc cgccttcgac aaacagcgtg 2935321 aaatgccatt tatcctcgat gccttccacc cagccatagc ggtcgccgtt atgatcgaaa 2935381 tgatacggct tcgcttcttc caggctccag ccgagacggt tttccaattc ttcttttacg 2935441 ttttctaaac cgaggcggtc aactgtgtat ttgaaccgcg catttttacg gacagaacgg 2935501 ttgccgtaat cacgctgaat cgtaatcgtt ttttcagcaa cgtcatacat ttgctcaggc 2935561 cggcagaaac cgatcacctt ggctaattgc ggatatgtcg cagtatcgcc atgcgtcatt 2935621 cccataccgc cgccgattgc cacgttaaaa ccgatcagct tgccatcctc gacaatcgca 2935681 atgaatccga gatcttgtga aaagacgtca atatcattag acggcggaac ggcaataccg 2935741 attttaaact tccgcggcag atagagcggt ccgtacattg gctcgacttc ttcctccggc 2935801 gtgccggcaa ctctttcctc atcaagccaa atttcatgat atgctctcgt ccgcggcagc 2935861 agatcatcac ttaatttttt agaccactcg tatacctctg agtggatttc agattgataa 2935921 gggtttgatg cacacatgac gttacggttt acgtctccgc aggctgcgat cgtatccaaa 2935981 agtgctgagt ggatcgtctg aatggttttc ttcatgttcc atttcagaat tccgtgcatt 2936041 tggaatgttt cacgtgtcgt caattttaat gtgccgttcc cgtatttctg ggacaggtca 2936101 tccatgacaa gccattgttc aggcgtcgag acgccccctg gcatacgcac gcgcagcatg 2936161 aactgatatg cgggctcaag cttctgcttt tggcgttcat ttcggaggtc gcggtcatcc 2936221 tgcaaataac tgccgtggtg tttcatcagg cggttatcat catccggaat tcccgcactg 2936281 attcgatcga gcatcacttc tttcagcgtg ccgcgcaaat aatcactttc ttttttaatg 2936341 cgttcaacat cacttggaga gccgtccggt gcttttagaa ttttggtcac catgttgaaa 2936401 aactcctttc aagtcaaatc aatatacatc acgctgatag cgtttttgct gctgcatatc 2936461 ggcaagataa gcctccgcct cttcgcggct catattgcct tctttttcga taatttcaag 2936521 caatgtgtta tggacgtcat gcgccatgtg cttttcatct ccgcaaatgt aaacagccgc 2936581 tccttcttga agccattcaa acaattctgc gctatgttca agcatgcggt gctgcacata 2936641 tactttttct tccgtatcac gtgagaacgc cacatccatt tttgtcagca caccgtcttt 2936701 gagccaattc tgccactctg tctggtaaag gaaatccgtg acaaagtgct gatcgccaaa 2936761 gaacatccat gcctttcctt ccgctcccgt ctcctcacgc tcctgcataa acgaacggaa 2936821 aggtgcgacg cctgtcccag ggcccaccat gataatcggt gtttcagggt ctttcggaag 2936881 cttaaagttt tgattgtgct gtacataaac cggcagtgtg tctcccggct gcagtcgttc 2936941 cgcgcacaaa atcgagcaga cgccttttcg ttcacggccg tgcgcatcgt agcggactgc 2937001 gccgattgtt aagtgcactt catccggatt tgcggataaa ctgcttgcaa tcgaataaag 2937061 gcgggcaggc atttttcgca aaatcgagac aaactcctgc gcagatacac taaatgggcc 2937121 atagtcacgg acgagatcaa gcaaatcgcg cccttcaata taggctttta cattctcctc 2937181 atttcccggg gctaaaagct ctctaagctc atcgttccct gtcagctggg ctgcctgttc 2937241 aagaagcggt tttgtgagaa cggtaatctc atagtgagaa atcagcgctt ctttcagcgg 2937301 tcggacatca ccttgcttat taagcgtcac aatttcttcc gggtcccaat tcatttcctt 2937361 aaggagcagc tcgacaagtt ccggatcgtt ttccggatag acgccgaggc tgtcaccagg 2937421 ctcgtaagtc aggccagatc cttcaagaga cagctccaca tggcgtgttt ctttatttga 2937481 tcctctgccg tttaaattta aattttctaa cacttcagcc cgaaacgggt ttgttctgga 2937541 atacgaagac tcaccggttt gtgacgcagc cgccggcgca ggcgcggcgc ttccgccccc 2937601 agcttcattt aatcctttca atacaccctc aagccattcg gctgccggtt catcatagtc 2937661 aagatcgcaa tcaacgcgcg gagaaatccg ttttccgccg agttcttcta agcgttgatc 2937721 aaattctttc cctgtctggc agaaaaattc gtacgaactg tcaccaagcg ccaaaacgga 2937781 aaagcgcagg tcttcaagct taggcgcccg tcttccgtgc agaaattcat gaaacgacag 2937841 cgcgttatca ggcggctcgc cttctccatg cgtactgacg acgattaaaa gattggttac 2937901 cttcttcagc tgattcggct taaaatcgct catggatgag acggtcactt gaaaaccgct 2937961 ctgttcaagc tgcttgccgg cattttctgc aagcccctgt gcgtttcccg tctgtgaacc 2938021 ataaagaacg gtcacttctt ttgaaacggc cggtgccggt gcttccgctg acacagctgc 2938081 cgccggcgta cccgcagctt cttgggcgga aacagattga gcggataaat atccgctcag 2938141 ccagattttc tgggattcgg tcaaggtcgg cagaaggcgg ttaaggagct ctgcctgctc 2938201 ctgattaaac ggactgttca ttacctgaag ttgcaacgta tccacctcac aaagttataa 2938261 actgatcgaa aattgcatct aattgaactt taccggaata ctaggcttaa gtaaaatata 2938321 tttacatgat gataactatt aagaatccta atgataaaac ggctatgctt catgtaaata 2938381 gaaaaaagag aaggactccc ttctcttcat tcagcaatct gatataagtg aggcggcaca 2938441 gcggttacaa acggactggc ttcacctgta taaaataccg ccagcatgtg catcgcacgg 2938501 gtgcacgcag tatataaaag cctgcggtcg tgctctgtat gatagtgttc ttcagatgca 2938561 tcatagacaa gcactgcgtc aaattcaatt cccttcgcta aatacaccgg aatcacgcaa 2938621 acaccctttt gaaatggttg attttcttta tgaatcaggc gaacatctgt atattcactc 2938681 atgtgggcgt gcgcctgtat gcattgatgc gcagtcttgc agatgacggc tattgtttcg 2938741 tgcccttttt tcttgagccg gccaatttct tgcgcgagct tttggcaaag gctctcatgt 2938801 ccttcagttt tgacaacgag cggcatttcc ccgcttctat taaacggctc aatatccgct 2938861 ccatcttgaa gcatcgcttt ggtaaactcg acaatctgcc ttgttgatct gtatgttctc 2938921 tttaaacgaa catactcagc aggctcatcc tcaaagcacg catccatacg ctgatccccg 2938981 tttatggtat gcgcgtagat ggactgattg atatcaccga gcactgtcat gctggcagcc 2939041 ggaaaaatgc ttctcatgta agccatctga aacggtgaat agtcctgggc ttcgtcaata 2939101 aatagatgtt tgattttcgt atttttcttt ctgccctcaa tcagatcctg catataaaga 2939161 aacggtgccg cgtcctcata gagcaattta ttatccgtaa atgccgaacg ggtcagctca 2939221 cctatcgcat ccatcttctc atgttgaaat tttcctcccc agccagaaaa caattgcaaa 2939281 taaagttgtg taacatcaag aaatgcaagg agcctgactg cctgtttgag cggtttgaaa 2939341 gcttttttca caatgatggc ggcaagcagc tgctgctctc tttgataatc gttaaacgta 2939401 ctctcgctga accgtttcct ttcctgcagt tttttgtaca cgtccaagta gtcctctttg 2939461 tcaagcagct cagcttcatg aacaacccaa tcctttcgcc gttccttttt ctcaagcttg 2939521 ttaagctcac tcagcagcca cttcgcggtt tgctccatcc gattcggaat ggagtgattt 2939581 tgatccaatg agtaaaaata ggattgaatt tgctcctttg tgatcagctt ttgtccgcgg 2939641 aatataatat ttttaaaaat catcccttca gaggaaagcc gtgtgacgta ttcattaatg 2939701 aattgctgaa aggataaacc cgccttccat gtgattcctg caagccttgt tggaaaatcg 2939761 cctccctttg tttcggtcag gcaatattcg agctgatcaa aggggctttc acatttgaac 2939821 ttgcggccaa gacgatgctc gatatattcc tgaaacgtcg cctgctccat attctcttct 2939881 cctaactccg gcaaaacaga ggagacatag ctgttaaata agaagttggg tgaaaacaaa 2939941 acgatttgtc cggcatcaat gacaccgcgg tgcctgtata acaaataagc gacacgctga 2940001 agcgcagccg atgttttccc gctgccagcc gctccctgca cgatcaggat cttgcttttt 2940061 tcattacgga taatctgatt ttgttctttc tgaatcgtag acacgatgtt tttcatttgg 2940121 gtatcagagt gatggcttaa tacctcttgc agcatttcat cgccaatcgt catatcggta 2940181 ttaaacatcg ccttgagagt gccgtttttg atcataaact ggcgtttcag caccatttcc 2940241 ccttctatcg tttcaccggg cacctcgtac tccgcttttc ctggggaata attgtagtac 2940301 aaacttgata tcggcgccct ccagtcatag atcagaaagt gttcctcctt ctcatccaaa 2940361 caggaagcta aaccgatata aattcgctct gcctgctcct cgccgttttc aataaaatca 2940421 atccggccga aataaggcga ttttttcaat tgatgaattc gtttgagctg ctgatccatg 2940481 cgccgatgat tgtgttcccg atcagacagc agctctgcct gctgcttaat gctagccatc 2940541 gtttcaatcg cttcatgggc atcatcaaaa ttaaccttaa catcctccca aaagcttttt 2940601 cttaatccga tgatatcatg cttcaacccg cccgcagacg tttccagaaa ccgctctttt 2940661 ttttcgagct ccttcagcac ctcatctatt ctcgactgct cttccttcca ttccttatcc 2940721 tgctgattca tgaacggcac ctccagaaaa tagttgacaa acatagatga aatactgtaa 2940781 aatataattg gatacatata ttaaatatat gatgcaaact ggcaaataca atttataata 2940841 gcacattcac ccaataccaa tcaaggtttg ggttatttat attatgcaga aaaaaaccga 2940901 tttcacttcg aaatcggttt ttttgctatt aattatctaa gcgaaaagaa cggtttggca 2940961 gcttccaatt aaacatatag gaacaaaccc ggcaaacaac gagcacgaaa aacagaacgt 2941021 ataagccgaa cgagttcccc agccagccca agccgacgat taaaccgccg agcgccgccc 2941081 ataccgcata gatttccgct ttcagcacaa gcggtttgcg cccggcaaga aggtcgcgga 2941141 tgatcccgcc cccgcttccc gtcagcaccg cagccacgat cacggcacta agcggatggc 2941201 ccattttgac ggcatacagt gcgccttgga tagcaaaggc agcgaggccg atcgcatctg 2941261 ataaattgcc ccacttattc caatgcttca gcagcagctt cggaaacaga aacacaattg 2941321 taatagataa aagcgcgatt tgaaagtacg ctccctgctc ccatagcgct gacaccggaa 2941381 caccgatcag caaattgcgg atcgctcctc ctccaaaagc tgtgacaatc cctaatatat 2941441 aaactcctaa aatatcatat tcctcttcca tcgcaacaat tgcgccgctg actgcaaacg 2941501 caatgatgcc aatcacacta agcagctccc aagccattct gatgactccc ttttatgttt 2941561 gttaaatttt ctgacgacct ctagatttta taatcgctcc agcgtaaaat caataacatt 2941621 ttcatgagaa aaaaagataa atttagaggg aatacggcta ttgctgatgg acatgagttt 2941681 gcgaaattaa aaaagcgccc ggcatacgcg ggcgcttttt ttgttattca gatttttcgc 2941741 ctttcagcag gcacataaaa atgataatca ggataaaagc aatcagggcc aggaatggaa 2941801 tcgtaataaa accaaaccag ttaatatatt ggcccgagca cggcacgccg ctgacacatg 2941861 gcttaatgcc gctaaagccg ggcacttttt gctctaagta atgcatgatc gaaatgaatg 2941921 ccccaataat cgccatcggg agcacatatt ttttcactcg tgtgtcccct tgaaaggtgg 2941981 cgatgcctaa aatcaggacg agcggataca tgaggatacg ctggtaccag cacagttcac 2942041 atggaataaa ctttctgatt tcactgaaat acaggctgcc cagcatagcg ataagagcca 2942101 caacccagga agcatataaa aatacgattc tatttttcat attgttactt ccctttcagc 2942161 tctttttcta ttgtctcttt gatttcatca taatccgcaa aatttttgat cactttatca 2942221 ttgacgtaaa tcgtcggtgt tgcctgtatg ttcatttttt gattaaggtc agaatccttt 2942281 tccacttgag aagcgaatgt ttccttatca agattttcct tgagcgtctc aggttttatc 2942341 tttgtggtgc tttttgcaag atcaccaagg aggcctgggg ttacccattc ctgttccgta 2942401 tccggctgtt tttcgaacag cttttcatgg aaatcccaga aagagtcagg gtcttccttc 2942461 catacttctt cagatgcaag agccgctaac cttgaacctt ttccatggaa catgacgttc 2942521 acgaaagaaa atttcacatc gcccttatca ataaagtctt tttgtatttt tggaaagatg 2942581 tcactgttaa acaccttgca agacggacat ttgtaatctc cgaattctac tacagttacc 2942641 ggtgcatcgt ccttgccaag cacaggctgc cctttgatag acggctgtcc ggacaccgca 2942701 tcattgcctt gttccgtttt gttattaatg atgacaatgg ctgctagcaa tacaacaacc 2942761 acaaccgtaa ggatgaccgc gaatttcgca gaagactgct gtttcttttt cactccgaca 2942821 cctcatcgtt ttaaaattaa aaaagaagcg gatcgcaatt gacccacttc tttattttaa 2942881 caagacaagc gctgataaga aaaccccgaa aaaatgaatt ctctccgaca atttatttgt 2942941 ttttgagacg catgacgcgc atggcgttcg ccacagcaag cagtgtaacg ccgacatctg 2943001 agaaaaccgc ttcccacatg gtcgcaattc caaatgcacc aagaatgaga aagatcgctt 2943061 tcacacctaa agcaaagccg atgttttgcc acacgattcg ccgtgtccgt ttcgcaatcc 2943121 gaatcgcttc tgctattttt gacggctgat ctgtcatcag cacgatgtct gcggcttcta 2943181 ccgcggcgtc tgagccaagg cctcccatcg caacccctat atctgcgcgt gcaagcaccg 2943241 gcgtatcatt gatgccgtca ccgacaaaaa tgagtttttc actaggcaaa agcttagctt 2943301 ctaatgcttc gacctgcgcg actttatctt gcggcagcag ctctgcatat acctcaccaa 2943361 tcccaagctg ttttccgacg gcttctcccg tttgtttcga atcacccgtc agcatagctg 2943421 tctgtttgat cccaagcgac ttcagatcag caaccgcctg tgctgcgtct tcctttatct 2943481 catccgctat gatgattgct ccggcatagc gttgatctac agcaacgtgt acgattgttc 2943541 cagcattttc atccgggaca tcctcaattt gttctctttc catgagcttt ttattcccag 2943601 caaggatctc agttccattt acctttgcaa aaatgccgtg accggagatt tcttcgtatg 2943661 actcaatctc atcggaggaa agcattttcc cgtaagcttt acgcacagat tcagcaatcg 2943721 gatgctgtga atgaagctca gcgtatgccg ccgcttcaag taatctatcc tttgtaaaac 2943781 cttccgcggg tttgatttct gtcacttcaa agctgccttt tgttagtgtt cccgttttat 2943841 caaacaccgc gtatttgact tgattcaaag cttctaaata attgcttccc tttacaagca 2943901 ctccggcctt tgaggccgct ccgattccac cgaagaaacc gagcggaata gagacaacaa 2943961 gcgcacaagg acaagaaatc actaaaaaga taagcgcgcg gtacacccaa tcggaaagcg 2944021 cggcgccaga aagaacaagc ggcggaacaa aggccagcaa taccgcaatg atcaccacag 2944081 caggtgtata atacttggca aacttcgtga taaagttttc tgtccgggct ttacggctgc 2944141 tcgcattctg aaccaagtct aatatttttg atactgctga ttcctgatag ccctttgtga 2944201 cttcaatatg cagaacgccg ttttgattga taaagcctga cattacatct tgtccttccg 2944261 cagcttttct cggaacggac tcacctgtta aagcagatgt atcaaccatc gctgaccctt 2944321 gcacgacctt accgtccagg ggtatgcttt ctcccggatt aaccacaatg atgtctcctg 2944381 tctgaacgtc ctccgacgaa acctgttcga tgccgttctt tgttttgaga ttggcgtaat 2944441 caggccgtat gtccattaac gcactaattg attttctgga acggctgacc gcggctcctt 2944501 gaaaaagctc accgatttga taaaacagca taacggcgac cccctcaggg tattgctgaa 2944561 tcagaaaagc gccgattgtg gcaagagcca ttaagaaatg ctcatcaaac acctgaccgc 2944621 ggatgatgtt tttgactgcg cggattataa tgtcaccgcc gataatcaaa taagcaccga 2944681 ggaaaaggaa aaattcaatg gttcccgact gaaccaaata tgccgctgcg ccgagaatga 2944741 cagccgccgc cattctgatc agcatattga ccattcgatt acgatagcca tcatcagctg 2944801 atttctttat atgcttttgg cgaaccgtta catgcggatc aattgatttc acttttttct 2944861 ctactttatt cgtgacccat tgctcttctt tcccatcggc tgagacagtt aaggtgcttg 2944921 ccgcaaaatt taccgcgcat ccgttaatgc cttttatgcc tttgactcca ttttcgattt 2944981 ttcgggcaca attgctgcaa tccaaaccgt ccagaacata ttcctgtttc actagtctca 2945041 ccttaccttc cgatttaggg ttccctcttc aaagcgtatc aatgagtatt gtatttattt 2945101 tatatatatg agcatatact catatataag ttacacctat tatatgttgt tttccaagaa 2945161 agtgtcaatg aaaaacaaaa accggcatat agccggtttt tcattttact ttttgcagac 2945221 gaagagcatt cagaacaacg gaaacggagc tgaatgccat tgctgctcct gctatccacg 2945281 gtgctaaaaa tccaagtgct gcgattggga tgccgaggct gttatagcca agcgcccaga 2945341 ataagttttg tttaatgttt ttcattgtca atctgctcat gcggattgcg tcggcaatgc 2945401 tgttcagatc gccgcgaata agtgtaatgt ctgctgtttc catggcaatg tccgtgccag 2945461 ttccaatcgc catgccgatg tcagctgtgg caagcgccgg cgcatcgtta attccgtcgc 2945521 ctaccattgc tgtctggcgg ccttcttttt gcaagcgggc gatttccgcc gccttttgtt 2945581 caggaagaac ttccgcaatg atattcgcaa ttcccgcttc cttcgcgatg gcttctgcgg 2945641 ttctgcgatt gtctcctgtc atcatgatga catcaagacc caactctttc agacgggcaa 2945701 cagccttccg cgacgtatcc ttaatcgtat ctgcaactgc tactagcccc gctgcttctc 2945761 catcaatgga tacaagcata actgttttcc cttcggcctc tagctcttcc atttgggcga 2945821 gaagagcccc atgctcaacc tgttcgctct ccattaattt tcttgtgccg acgagaatgc 2945881 tttttcctcc ggcttcagcc aaaatgcctg cgccgacttt tgcttcaaag cgggtaagtt 2945941 tcggtatctc aagcccttta tctttcacgc cagcaataat cgcttcgcca agcggatgct 2946001 ctgatcccgt ttccgctgcc gctgcaaatt gaagcaaatc tttttcttca aaacggccga 2946061 atggaatggc atccgtcaga cgcggcttcc cgtttgtcac ggttccggtt ttatcaagaa 2946121 caattgtatc gagacgatgt gttttttcta aatgctcgcc gcctttaaat aaaatcccga 2946181 attcagcagc gcgtccagat ccagccatta tgctcgtcgg agtggcaaga ccgagggcgc 2946241 aaggacaggc aatgacaaga accgcaatga acttgctgat cgcttcggca aaatcgccag 2946301 gagccgccca aagataccaa atgagaaaag tgagaaccgc aatccccaat acaatgggta 2946361 caaaaatgcc tgaaatctgg tcagcgagac gctggatcgg cgcttttgac ccttgtgctt 2946421 cctcaacaat tttgatgata tgagaaagcg cagtatcctt tccgacgttg acagctttaa 2946481 ttttcagaaa gccgtttgcg ttaacggttg aacctgtcac gctgtcacca ggatttttgt 2946541 caacaggaag actttctcct gtaatcatcg attcgtcaac cgctgaacgg ccttcaacca 2946601 cttctccgtc gacaggaatt cgttcgccag gtttgacgta aacaatgtca ttaacaagca 2946661 cttcgtcgat cgggatgatt tgctcctgtc cgtctcttac aacagtagct gttttcgctt 2946721 gaagcttcat cagcttttta atcgcatccg aggaacggcc ttttgctttt gtttcaaaca 2946781 acttgcctaa taaaatcagc gtcagcaaaa tcgcgcttgt ttcataataa aggccgtctg 2946841 tatgcccgtg agagccaatg ctttgaaaag ttagataaag actataagcg taagcagccg 2946901 tcgtaccgag ggcgaccaat acatccatat tggcgctttt atttctaagc gccttatacg 2946961 cacccacata aaacggccag ccgatcagaa actggactgg tgtcgccagc gcaaactgca 2947021 tccacggatt gagaaatata tccggtaccc aaatgaatga tgtaaatgta aaatggctca 2947081 ccatcgccca aagcaatgga aatgacagga cagctgaaaa aatcagtctc gccgtttgct 2947141 tccgttcttc tttcttttta gcagcagcct cactgtcctg ttcacccttc aactttagct 2947201 tatatccaag cttatctacc gcttctttca aatcgctgac agacgcttct tttggattgt 2947261 attcgaccgt aactgtttct aaagcgaagt ttactggtgc atttgcgacg ccttctattt 2947321 tgttaagccg tttttcaatc cgattggcgc aagccgcaca ggtcatgccc tcaatatcga 2947381 attcagcttt ttctgtaacg acgtgatagc ccagcttctc tattttttcc tgaatcgctg 2947441 cagtccctgt ttcagcagga tcgtagatta catttgatgt ttccgttgcc agattaacat 2947501 ttgcatccgt gacaccgggc atccgcttca ggcctttttc aattctggca gcacatgccg 2947561 cacaggtcat accagagacc tgcatcgcga tttccttttg ttcactcaac atactcactc 2947621 ctttatatac acctgggggg tatataaaaa tgaaagaaat atcgcgcctc cctaaaggcg 2947681 cgataccttg aatcacttgg ctacgtcata gccctgatct tctatcgcat ccgcaatatc 2947741 tttgactgat actttgtcag catcaaacga aacatcgact ttacccgctt ccagattgac 2947801 atgaacggca ctgacgccgt ccagttctcc tacgcttgtt tctactgctt tgacgcagtg 2947861 ctgacaagac attccttcaa cttgcaatgt tttttgttcc atatcaattc ctcctgttta 2947921 ttctttctat tttcatccta ccataccccc gtagggtatt acaataaaaa acgctttatg 2947981 attttgtgaa ctttttaaat acgtccaaaa gctcagaaat ggcctgttcc ccgtctccgc 2948041 ttttgatggc atctgctaca caatgatggg catgatcctc aagcaaatga agcgccacat 2948101 ttttcattgc cgcctgaaca gctgaaattt gcacaagaat atctacacaa tatctgtcgt 2948161 tttccaccat gttttgaatg cctctgacct ggccctcaat ccgcttaagc cggtttgtaa 2948221 tctgatcctt ttctttcgag cttttatggt ttaatgtttt atgttcgtta tgcttttcca 2948281 tgcgtacacc tctgtttaat gatattaatt cccattatac tgattgtcca aacggttgtc 2948341 taagcatgcc gacgcaaaaa atgaatcagt taggttttac catttgatca ggagggtata 2948401 tacttctgtt gataacgctt ttaaagggga gaagaaaagt ggatacgatc aaggttggaa 2948461 tattaggata cggattgtcc ggttctgttt ttcacgggcc gctgctggat gttctggatg 2948521 aatatcaaat cagcaaaatc atgacatcac ggacagaaga agtgaaacgg gattttccag 2948581 atgctgaggt tgtacatgag cttgaagaaa tcacaaatga ccctgccatt gagcttgtca 2948641 ttgtcaccac cccgagcggc cttcattacg agcatactat ggcatgcata caggccggaa 2948701 aacatgttgt gatggaaaaa ccaatgacag caacggccga agagggggaa acattaaaaa 2948761 gggctgccga tgaaaaaggc gtattattaa gcgtatatca taaccgacgc tgggataacg 2948821 attttttaac gattaaaaag ctgatctctg agggatccct tgaagatatc aatacatatc 2948881 aagtttccta taaccgctac agacctgaag ttcaagcgcg gtggcgggaa aaagaaggca 2948941 ctgccactgg tacgctgtat gatctcggct cccacatcat agaccaaacc ctgcatttgt 2949001 ttgggatgcc taaagccgtg actgcaaacg tgatggccca gcgggaaaat gccgaaacgg 2949061 ttgactattt tcatttaacc ctggattatg gcaagcttca agccattcta tacggaggat 2949121 caatcgttcc ggcaaacgga cctcgttatc aaatccatgg aaaagattct agctttatca 2949181 aatatggaat tgacggacag gaagacgcac tcagagcggg aagaaaacca gaggatgaca 2949241 gctggggtgc ggatgttccg gagttttacg gaaagcttac aaccattcgt ggctccgaca 2949301 aaaaaacaga aacgattcca tcagtaaatg gctcctacct tacttattac cgtaaaatag 2949361 cggaaagcat acgagaaggt gctgcgctgc cagtcactgc tgaggaaggt attaatgtca 2949421 tccgcatcat tgaagccgcg atggaaagca gtaaagagaa acgaaccatt atgctggagc 2949481 actaaaacaa aagcctcccc aaataagggg aggctttttc attagaatgt ttttcctgct 2949541 tctttcgcac gcgcaatcgc gtcttctttg atttgctgtg ctttatcagg ctccgcatta 2949601 tgtccctcta cgaaaatgcc atcgaatgat ggtacgccga agaagttcat catgatgccg 2949661 atgtagcggt gccccatttc catctcagcc gcagggcctt ctgaatagta gccgccgcgc 2949721 gcttggatat gaattgcttt tttatcagtt aacaagccga caggaccttg ttctgtgtat 2949781 ttgaatgatt ttcctgcaac agcaacagaa tcgagatacg ctttcatcac tggcgggaat 2949841 gagaagttcc ataaaggagt aacaaatacg tacttatcag ctgatgcaaa ttgatcgcta 2949901 agctctccca aacggcctac tttcgctttt tcgctttcag aaagctcttc aaagcctgta 2949961 cctgactgaa gctttcccca tccgctaaat acatctgcgt caatgtgcgg aatgttttct 2950021 ttgtacaaat cgatatgtac aacttcatca tttggattcg cttctttgta agattcgata 2950081 aatgctttac ctgttgccat actgtacgaa gttgcttcgt catgtggatg agcagtgata 2950141 tataatactt ttgccatttt taccagccct ttcgttttta aaaatcacac atcaattatt 2950201 atcatacaga tgcataatga ttattctgtc tctcttagac tttattatag agacaaagaa 2950261 atttactttc aagtaaaaca tctcgaatta aagattattt aactttccca aacagcttac 2950321 ttttcaaaag ctgttctcaa gccggaatac agcgcggaca attctttact gatccgagga 2950381 taatgaggga catgcggcac ttgaatatcc gcaggcatcc ttttcatgat aaaggattgc 2950441 tcagcctgtt caaaaaacgc ccgcagctgg ttgatctctt catcagaaaa cggagcagac 2950501 ggacggcggt gagcttgcgc cgagagcaaa tagtacccta agtgctgagc accggaaatg 2950561 gcaggccaga gcgcatccgc attcgcgtga ggaaactcgc caagcgcctt gtcatacgca 2950621 tcccgaagcc tgacaagact cacccttaac ttgtgttcgt cggcaatttg cccggttaac 2950681 agtttctcca taaactgccc ttccagccgg atgacattcc gcacaagttc tggcagccgc 2950741 ttggttgaaa accgccgcca caaaagcatt gttcccaaca gcccgatcac gctgccgaca 2950801 gctacatcag tcagcctcgc tatcataaaa taaccggcgc ccgccccgcc atgcatactt 2950861 tctgtgataa caagcgcatt tgcggttaaa aagggaacag ccagcgcata attgcggacg 2950921 atcagcatct caagaagaca ttgcagcgct gcaatacaaa acgcaatata aacaccgccc 2950981 ggcttaaaaa acaggattgc gcctgccagt ataacaccga tcaccgttcc ggccgaacgc 2951041 tgaatagccc tgtgaagcgt aaaaacaaca gtagtgccaa gcatgaccgc tgctgccgaa 2951101 agcggaatcc aataggagcg tgcaaagccg aatgcgaggg caaacatatc ggcggcaaac 2951161 agaacaattc cgtactttaa cgctctaatc aaaactggag acttccagtc aaaggcattt 2951221 ctcaaaaagt aaaaagagga tggcaggcgg cttggttccc cgtcaagctg cttatcaaaa 2951281 cgtcctgaag cgatatacaa aacctcattg atttcttcaa acagcttccg cctaggctca 2951341 gattcatttt cattaatctg aaacgtattg aaaacccgtg cattcgcaag catatctccg 2951401 gtttggcgaa gtgccttttc aatctgcgcg gtctctctgt ccggcgtttc agctgaaaaa 2951461 tgaataatgg caataaatat gtcgtcagct ttctcaagga ggcgaaaaaa tcgttcatca 2951521 tgccgcgatt ttttccgtct gttccctttc ccaagaaccg tttggcgggc tgttctaagc 2951581 atgagcaccg tctgatgctg tgcgttatga aaacctggcg ttccgacggc tgaaagacat 2951641 gcagccagct gatgatatgt tttttgcagc accgctccct ccggtccatg tttgttccat 2951701 aaccagccga ttaaagcgat acccatggcg aaaatgccgc cgagaaacgt cagtcccgct 2951761 ctgaacagcg cttgtgaagg atcggccggc agcccggaac tgactaaaaa ggcaaggaca 2951821 aaaaacatcg gcgcagggcc ttgaatgccg agcgcgctaa aaataaacat cgccgctgca 2951881 ccgatcagcc ccaaaacagc cgccatcatc caaagcatcc cggacaaaag cgtccctaaa 2951941 ccaaatgaga gggcgatccc aatagaaacc aagagcagct tcaaggcgcg ctttttgtac 2952001 gattcaccgc ccgcatataa ataaacaaag cctccgatac ttgcaattaa tccgtaatcc 2952061 gtgtgacctg ccaatgcacc gaccagcaca ggaaaccctg aagcgaaacc tgatccgata 2952121 gcctttttcc aaggaaatgg atttgcatga atgcgaaagg catccttcac gataggcatg 2952181 attctttgat tgttcgcagc agttttgttc atttgacaaa atccttttca atgaatgtgt 2952241 agaacttttc cagtttcttc gctttagtat gcccaaaaac gcggttagct tctcaattgg 2952301 tgcgcacgat aaaaaaacag agacttatac cgtctctgct tcattacatc agtttattat 2952361 aaaagcggca cctgtcagga ctgttttgtc cttctgcctt ccttcaagag caggtgaata 2952421 aaaaataaag gataaatcaa tagataccca ttaaacagcc accacacaag atcaaagtca 2952481 ctgctgaatg tccagaatga tagcgcctgc agacctgaac aacaggtcag cacaagagaa 2952541 atcagcgcca tcagcttcca gtcagcacga ttcacccgct gtaggtacaa gctgtacaac 2952601 cctgtgacag aaatcaggat atccagcgga aaaaaagacc agttccaagc gatcataaac 2952661 ggatggtcat gatgtttaaa agcccagctt tccggtatga gcgaaaatcc ggctgacagc 2952721 cagtacaaga taaaaccgat atcagtcacg agaaaaaaca gcttcatata tctcatttgt 2952781 actgcccgct tttatgtacc ggctcagaca ccgcaacatg ctcgatcagg tttaaagaca 2952841 caacaccggc aataatcaat ccaattgaaa tgactttcat gacactcaca tgttcttgaa 2952901 aaaacaaaaa accaacgact gtaatcaaga caattcccat ccctgaccat acagcataag 2952961 caactgatac atcaatggat ttaagcgtaa gcgtcagaaa gaaaagactc cctccataaa 2953021 agaaaatcaa cagcaaactg ggaataagct ttgtaaaacc agacgatagc ttcatgctga 2953081 cagttcccgc aacctcaaac aaaatcgcca agcatagaaa cacccaattc atgtggcatc 2953141 agcctcctca tcagctgtta taccgttaaa caaaacatct acaattgatt caagtacctc 2953201 tcctgtcgtg aactgatgtt tcagcggata ttcagggtca tacacttgat tgatgctccc 2953261 tatatacatg tgaacaaaca ggtccggatt gatgtttctg attctctttt gctgtttgca 2953321 ctcatttaat aatgctagga caatcgccca ttcttcctta ataaacgcgt ctaatgtaag 2953381 ccacgcatcg taatggtatt tctttagttc atttaataat cccatgttca gcagttccat 2953441 cccctgcgga aggctgatca gcatttgttt caccttttcg agcacattta aactttcatt 2953501 ttcatagatg tctctttcta tttgcttcat ttcagctata aattgttcga caaccgcctc 2953561 aacaagctga tctttagatg aataatatgc atagagcgtc cgcttgctcg ttcccagcgc 2953621 tgccgccaaa tcattcatcg taaatgaaaa tcctttctgc ttgatcagcc ggaaggtttc 2953681 cgccagaatt cttttatcca tattaatccc ccgctttcgg taccaagaaa actatttcgg 2953741 taccaatatt atacggcaga aatttatgga aatcaacaat atataaaaaa acctctccta 2953801 ttgggagagg tttaaaagac actgcggacc aaaccgccgt ccgcccgaag tgccgcgcca 2953861 ttgatcgcag aggaaagcgg actgcttaaa aatgtaacga agtgggcgat ttcttccgga 2953921 cggatcagtc tttgaataat agatgtcggc cggttttctt tcataaaacg tgcctcagct 2953981 tcttgaacag tcaggttttc accaggatac agcgagttca gcatggtttc cacaccctct 2954041 gttaaggtag agcccggcat gacggtgttg actgtgacat tcgtgccggt tgccagctcc 2954101 gccaaactgc gggaaatgga cagctgcatc gtttttgtcg cactgtaatg ggccatttcc 2954161 tgtgacggca taatcgccgc ttcactggca atgaaaatca cacgcccttc ttttttctct 2954221 atcatgttat gcaaatacct gcgtgtcagc cttacaccgc tcataatatt cacttcaaaa 2954281 aaacgaaacc attcatcgtc gggaatatca aagtactccg ccggttcaaa aatccctaaa 2954341 ttgttgacca aaatatcaac ctctggatat gcctgaaaca gctcattgca gccttcttct 2954401 gttcccaaat caaatgcagc cggataaaga accgcttcag catgttgtgt tttcagttca 2954461 tctatcgttt gattcacttt ctcttcccgg cgtccgttaa tgatcactgc cgcaccttct 2954521 tcagctaacg aagaggcaat agcttttccg atccctgatg tcgaaccggt caccagtgcg 2954581 gtttttcctt gtaaattcag cttcattatt catccctccg tttttgattc ctcttattta 2954641 ttgacagaaa tctgattggt gaaacatctg ctctgcaatc agtatgaaac agctgggatt 2954701 gaaatggaag tacgcacttt ttggtgcctg tggtttggag aaaaaataaa gcagaacctc 2954761 ttaagaggtt ctgctttatt gtcagtatgt atggagacgg tgggagtcga acccacgtcc 2954821 agaaacatcg attacttaag cgtctacgag cgtagcctgc atatttatgg tttcactcat 2954881 cttcttgcct gcgggcgggc cttccgagag ctagtctgtt catctcttct tacgttctca 2954941 gacgggaacg caagcgtagc ctacttggat gtgctcttca cagacacata ggcaatgtca 2955001 ggaagagctc gctgcgctta ttaggcagct aatgctacgt tttggttaaa actgttagtt 2955061 ttgccagtta tatttaagtg cgtgtttacg agatcgcctc tcggctcgca gctcaagctc 2955121 gatccatccc tgtcgaatcc gtaacgtccc cttggtataa gggaaatacg ggagaaaata 2955181 tcaagctctc actcaaactg gctatagtct tattataaca tgatcacggc tcttttcaat 2955241 tgtcaaatcc ttcaaatgaa tggcgtcgtg atctgatcgt gaacacagta tagcacaggc 2955301 ctgattttcg aatcaagcac tatgccttta gaagcctttt tgactgtctc tgaacgctct 2955361 ttcgatttcc cgcttcgcgt ccttgcgctt cagatcttcc cgtttgtcat agttcttctt 2955421 cccttttcca aggccgagaa gcactttggc aaagccgttt tttaaataca gcttcagcgg 2955481 aacgagagaa tagccttttt cctttgttaa cccgatcagc ttattaatct ccttgcggtg 2955541 cattaacagc tttcttgtcc ggagcggatc gtggttatag cggtttccct gctcatatgg 2955601 gctgacgtgc atattgtgga gaaacacttc tccccgttcg attttggcga aggaatcctt 2955661 aaggtttacg cggccggcgc gaatcgattt gatttcggtt ccttgcagaa cgatgcctgt 2955721 ttcataggtt tcttctataa aataatcgtg gttggctttc ttattttgag ataatacttt 2955781 tcctgaccct tttggcatgc cagaacctcc tctctctaag gaaaaactgt ccaccttttg 2955841 cgatacgctc tattttacca aatgtcacgt accgctacaa tgaaaagctg tttccgaaag 2955901 aaagcaaata gagcgctgcg gccctatttg ctggttgagc tgctatttct tctttttccg 2955961 tttctgtttc ggagcattct ggaagccgcg ttttttcttt ttcttcttcg gcttagtgaa 2956021 ccactcccct ttttcctcag acggagctgg agaaacaggt gtattggtgc tttgaacacg 2956081 ttttctggca ggctttccgc gttttctgct ccggctgctg tccaattctc tcggacgccg 2956141 cggagtgcct ttcatgccga caatttcaaa gtcgatattg cgctcatctt tattgacatc 2956201 gacaaccttg actgtgattt catccccgat gcggaagacg ttgcctgtcc gctcgccaat 2956261 cattgcgaaa tgctgttcgt caaagcggta gtagtcatct gtcataaagc tgacatggac 2956321 gagtccttca attgtattcg gcagctcgac gaacattccg aagtttgtca cagagctgat 2956381 catgccgtca aactcttcac cgattttatc aagcatgtat tccgcttttt tcagatcatc 2956441 cgtctcacgc tcggcgtcaa ctgcacggcg ctccatagat gatgtatgtt cggcgatatc 2956501 cggcaggcgt tcagcccact tttcctgtgt cgcttcatcg accttgccgt tgatcaaata 2956561 cgttcggatc agacggtgaa cgattaagtc cgggtaacgg cggatcggtg atgtgaaatg 2956621 cgtatagaat tccgttgaca gaccgaagtg ccccaagctt tgcgggtcgt atttcgcctg 2956681 tttcatcgaa cggagcataa cagtagatat aaccgtttcc tctggtctgt cacgcacagc 2956741 gtccagaatg ctttgcagcg cgcgcggatg aatattcccc gccgttcctt tcaccacata 2956801 gccaaatgtc gtcacaaatt ctaaaaactt ttgcagcttt tcagcattcg gctcttcgtg 2956861 aatccggtat ataaacggga cattcatcca atggaaatgc tccgcaactg tttcgtttgc 2956921 tacaagcata aattcttcaa tcagcttctc ggcgacagag cgttctctga tcacaacgtc 2956981 tttaaccgct ccttcgtcat caacaagcac ctttgcttct ttgaaatcaa agtcaacggc 2957041 gccgcggtcc atccgcttat cgcgcagaat ttgagccaga cgctccatgt ctttgaacat 2957101 cggaacaaga ggctcgtatt tttgtttcag ctcttcatca tcatcaacaa gaattttatt 2957161 cacatctgaa tatgtcattc tttccgttgt tttgatgaca ctttggaaga tctcgtgctc 2957221 tgtcacctgt ccctgactgt taattgtcat ttcacaagaa agcgtcaggc ggtcaacctt 2957281 tggatttaag gagcagatgc cgtttgacaa tctgtgcgga atcatcggga tgacacggtc 2957341 aaccagatac acacttgtcc ctctttcaag cgcttctttg tcaatcggcg agttttcggt 2957401 tacgtaatgg ctgacatcag ctatgtgaac gccaagcttg tagcttccat catcaagctt 2957461 cgtcacggta actgcatcat ccaaatcctt cgcatccgca ccatcaatgg tgacaatcac 2957521 ctggtcacgg agatcacggc ggtctttcag atctttttca tcaatcgtgt caggcgtact 2957581 tgatgcctgt tccatcgcgt cagctggaaa ttctcccggc aggccgtgct tatgaatgac 2957641 cgataaaata tcaatgcccg ggtcgttttt gtggccgaga atggtttcaa cctcaccctc 2957701 tgcgttcatg cggccttcag gatagctcgt cagcttgaca acaaccttat gcccttccgc 2957761 agctccattt ttcccatttt tcggaatgaa gatgtcactc gtgatttttt tgtcgtccgg 2957821 aatgacaaag ccgaagtttc tcgtttctgt atacgtgccg acaacccgct gaatcgctct 2957881 ttctaaaatc cgtatgacgg ttccttcctg cctggagccg cttgattgtg agttcagacg 2957941 caccatgacg atatcgccgt tcattgccgt atttagctca ttaggcggaa taaacacatc 2958001 acttaacgac gtatcctcag gcagcaaaaa ggcgaatcct ttcgcatggg ctgaaatctt 2958061 tccttttatt aaattcatct tctccggaat gccgtagcgg tcgcttctcg tccgtacgat 2958121 aagccctttt tcttccaagg cgactaacgc tttgacgagc tctttaaact cctcggcttc 2958181 cgtaatattt aacatctcct caagttcctg aacggtcaga ggtttgtacg cctcttcctt 2958241 cataaacgag agaagctttt ccataaatgc ttctttttcc attatccgac ctcctgttga 2958301 ttaccaatcg agcttctcta aaaattcata cacatcctga tggacgaggt cacgttcttt 2958361 gtcgagtgta atgacatgcc ctgattcctc gtaccatttc agctgtttat catcagtttc 2958421 cacttcgttg taaataatat tggcgctttc ggtattaatc atgtggtcat gacgggcctg 2958481 caccacaaat gtcggtgaat aaatcatatc gacattattc cgcacatcag caattaagtc 2958541 ttgcagcgcc ttgagggtat tcatcggcgt tttttcgaat tctttcattt cctcttcaat 2958601 ttgctccggg cttttcccct caaacttttt gtaattgcga gcgtatgaaa gaacgccttg 2958661 atacatgacc tcttcactct taatatgcat cggtgcgcac attgggacaa ttccctttat 2958721 gggtacagtg taacccaatt tcagcgaaaa aaccccgcca agcgacagtc cgcaggcagc 2958781 aatgctctca taaccttcag attttaaata ttcatagcca tccattacgt ttttccacca 2958841 gtcttcgggc cccgtatgta caagttcttc aggcgggacg ccatgtcctt catattgagg 2958901 cgcgtggcac gtatagccgc gttcattcaa atatcgtccc agcatcctta catccgctgt 2958961 atttcctgta aagccatgca gcaaaagcac cgctttgtct ccgcctttaa atgtaaatgg 2959021 ttttggtgtc acaactttca tgctcatgtc tccctttcta tctgcacgat cattttagtt 2959081 ttccacagtt taatcagaaa aaaacgtttt gaatatcatc cagaaacgtg aaaaaggcct 2959141 gacttcacat cagaccttat acaaacattg ccctatagga tataagcaag cgcaatcgtt 2959201 aacacgaaaa acaagactgc cagcactacc gtaatgcggt gcaaaattaa atcaagacct 2959261 cttgcttttt gtttcccgaa gagctgctcc gctccgcctg aaatcgcacc agataatccg 2959321 gcacttttac tggattgaag caaaacgaca ataataagtg caatgctgac gataaccaat 2959381 aaggtaatca aaactgcgtg catcccatac acctccagac tcactggcta cattacttct 2959441 attttacatg aaaagggttg gcatgtcacg ctgtatcaga cgccaaaagg ccggataaga 2959501 cgttttatct tggttaccct attcatatga aaaggtcaaa ggagaaaagc gatgccgctt 2959561 atcagcatag acagcaggaa acatcttttt tatgaagaat atggacaggg aatccctatc 2959621 atttttatcc acccgccggg catgggacga aaggtttttt attatcagcg ccttctatcc 2959681 aagcatttca gggtgatttt tccggattta agtggccacg gtgatagtga tcacatcgat 2959741 cagccagcgt ctatttccta ttacgcaaac gagatcgcgc aattcatgga cgctttgcac 2959801 attgataaag ctgtgttatt cgggtattct gccggaggct taatcgcgca gcatatcggc 2959861 ttcacccgcc cggacaaagt gtcacacctt attctgtccg gcgcctaccc cgctgttcat 2959921 aacgtaatcg gccagaagct gcacaaactg ggaatgtatc tgcttgaaaa aaaccccggt 2959981 ttgctcatga aaatcctcgc tggcagccac acaaaagaca gacagcttcg cagcatatta 2960041 acagaccata tgaaaaaagc agaccaggcc cattggcatc agtattatct ggattcgctt 2960101 ggctacaact gcattgaaca gctgccccgc ctagaaatgc caatgctgtt tatgtatggc 2960161 ggcctgcggg actggacctt tacaaacgca ggctattacc gaagatcgtg cagacatgcc 2960221 gaatttttca gattggaata tcagggacat caattgccga caaaacaatg gaaaacgtgc 2960281 aatgagctgg tgacagggtt tgtgctgaca catcattcat aggaatagaa aacgcttggc 2960341 ttccttgcgt tttttgttac tttattgact tttgtcaacg aaatcatagt aaaaaagatc 2960401 ctcaaatttc aaattaaaat agtgaagcat tttaccaatc acaagctgcc ccggccttct 2960461 ttctccattc agcacgcggc tcagtgtggc gggtgagact ccgatttcca gcgcaagctg 2960521 attaagggaa taatcgttat taaccatata ctgcaagaca taatcacgtc taatctgtat 2960581 cttttctact ggcactttcc tcaccttcca ttcctgaaaa acttttttct atacttttac 2960641 attacggctt atgttaactt ttgtcaatac atttccagtc tacctattcc ctttagtcaa 2960701 taaacatact aaaatatgag taacagtgag ggacggggtg agatatatgg aaagctttgg 2960761 cgaacaatta cgggcattgc gtgaagagag aaagttaaca gtcaaccagc tggcgactta 2960821 ttcaggcgta agcgcggccg gcatctccag aatcgaaaac ggaaaacggg gcgttcccaa 2960881 acctgccacc atcaaaaaac tggcagaggc cttaaaaatt ccttatgagg ggcttatgta 2960941 caaggctggt tacatcgaag aagtgcatga agccagggcc ccttatgaaa cgaagtgcaa 2961001 gctgcttgaa aaagcggagg cctatgacct gaaaaacctt gcgcttcttg agaacgaaaa 2961061 gtggcaatat ctcaataaag aagatttgct catgctggat cattattttt cgtttatttc 2961121 agatgaagcg aaaaaacggt ctgctgatga ctgactcttg atagaaatgt gaggcgatag 2961181 accatgtcac cgttcggaca gcaattacgg gagctgcgcc gcgcccgcaa actgacagtg 2961241 aatcagcttg cggtgtactc aggcatcagc tcggccacca tttcaaaaat tgaaaacggc 2961301 aaacgcggga cgccaaaacc cgccacgatt aaaaaactgg cagccgtcct gaaagtgccg 2961361 tacgaaaacc taatggccgc cgcaggccat attcaggcct ttcctgaaga aatccgcgaa 2961421 gcatctgaag gctatcaatc cgtttatgaa atttaccaga cggctgtcac acgcggagcg 2961481 gagcacctcc cgattttcaa tagtcaaaaa tgggaacatc tctcaaagca ggatattgaa 2961541 aatctcagca aatacttcga ttttttgtct tcagaagcaa aaaaacgcgc ctcttcctca 2961601 taatcccctg tttctctttc tatattttat caatcacgct tgcatgccct ccctcgttat 2961661 ttgcgttata atagtgacag acgaggtgaa aagtatgaac caatcagaaa tgtgtcctag 2961721 atttgaaaaa gcagtcgaca tcttaagtaa acgctgggtc gctttaatcg tatttcagct 2961781 cttgaacggg tcgcagcgat ttagcgaaat tgaagcagca cttccaaatc taagcggcag 2961841 agttctgtca gaacggctga aagaacttga gcttgaagga gtagtgaagc gggatgtcat 2961901 ccctgaaact ccggttcgca tcgaatattc attgactgat aaaggaaagg cactagcacc 2961961 catattaggt gagatttcta aatgggcgac tgaatggatt gacccttcct ttcttgacta 2962021 attgctaaaa tggttctgat ctcaaagacg agaaaagaac cgttttttat tttccaggtg 2962081 aaaaaaagat atctcagccg atatatagta catccacaca ttacgttttt aaaggagacc 2962141 actatatgcg actgacgatt tcccgcaaat tcagcctggt atttttgaca ctgatcctga 2962201 tcaatttact tgtaggcgga ataggcgttc ttaatatgca gcatatcatt caaaaaacag 2962261 atgaaatcaa cacaaaatgg attgacggca tcaaaggaat cacttcaatt aattatgtaa 2962321 ccgagcacct gtcttctaaa gaaaaggact ttctgattta tacagacaaa agtaaaatgg 2962381 atacacttga tcaagaaatg aatcaaatca tggaagacat taaccaaaag ctcgataact 2962441 acgaaaaaac gatctccact gataaagagc agaaactgtt cgagcagctt caaactaaag 2962501 tgaataccta tatggatatt catgcgcaaa ttatcgaaag cggccgcacg aatgacatgg 2962561 acaaagcaag aggtttattg gttcagactg aggccagctt tgaggatatg aaaaaaacaa 2962621 tcactcagct tgttgactta aatcaagaag gcagcaacac agcggtaaaa gaaacgaagg 2962681 ccgtctatca taaagggctc atttacactg ctttgcttgt ggcagcatca atcctcatca 2962741 gcattttcat ctggctttat atcacgcgaa acattgtaaa gcctatcatt cgcatgaagg 2962801 aatctgccaa tcatattgcc gaaggcgatt tgtcgaacga tatggaggcc ctcaactcaa 2962861 aagacgagct gggtgatctg aatgaagcgc tgcaaaaaat ggtagggaat ctgagagata 2962921 ttgtcggata ttctaaagac atatcaagcc gggttctttc ttcttcacag gtgcttgcaa 2962981 ccgcaacgaa tgaaacaaga tccggcagca aacatattac cgagacgatg aacgaaatgg 2963041 ctgagggctc tgaacagcag gcccaagacg cggtgacgat tgccgaatcg atgaatgagt 2963101 ttaccgaaag cattgataaa gcctataatc acggcatcac aatcagcgat acgtctcaaa 2963161 acgttctcga actcgcggta agcgggaacg aaaatatggc tacgtcatta cagcaaatga 2963221 aaaccatcca tcatattgtt gaagaagccg tgcataaagt gagatcactg gaacagcatt 2963281 ctcaggatat taacaagctc gttcaggtca tcaacgggat tgccgagcag acgaatttgc 2963341 tgtcccttaa cgccgcgatt gaagctgccc gcgctggaga aagcggcaaa ggcttcgccg 2963401 ttgtggcaga ggaggtcaga aagctggctg acggcgtttc tgattccgtg caggacatta 2963461 cccggattgt aaacgggaca cagcaggaga tccacactgt cattacgtac ttggaaagca 2963521 gctttacaga agtcgaaaaa ggaacggaaa acctgacaga caccggacag gctatgcagc 2963581 atatcaaaca atccgtcacc catgttgcag acagcattaa ggaagtaacg gatggcttga 2963641 agcagttaac aaaccaatcg attaccatca atcaatcgat tgaaaatatc gcttctgtat 2963701 ccgaagagtc tgccgccggc attgaagaaa cattttcaat taccgagcaa tccgcccatt 2963761 cgatggatca agtgcttcta aatgctgaag agcttgagca gctggccaat gagcttaatg 2963821 agaagatggg tcagtttacg atttaaagag aaaaaagagg ctggactcca gcctcttttt 2963881 ctattctatg cagctgattg aacatgtttc gccccggttc tttttttctt caccggactt 2963941 aatgcccgct ccagccaagc catgagcaaa tccgccccta ccgccatcac cgcagttggt 2964001 atcgctccgg ctagaataat cgcagttccg tttgttgcgt ttgagccgcg tacgatcatg 2964061 tccccaaggc ctccggcacc gacaaatgtg ccgatcgctg taattccgat ggcaatgacg 2964121 agagccgtgc gaaggcccgc cataatgaca gaaagtgcga gcgggagctc aaccattctg 2964181 agcacttgga atttcgtcat gcccattgct tttccagatt ctaagtaggc atgttcaata 2964241 ctgataatgc ctgtgtacgt gtttcgaata atcggcagca gggaatacag aaataatgat 2964301 agaatcacgg tatttgcgcc gagccccata acaagcatta agacggccag catagcgagc 2964361 gccgggattg tttgaataac gtttgttacg gcaaacaccc aggctgacaa acggcgaaaa 2964421 tgcgcgatga ggattccggc cggaaccccg acgacagcgg caaataaaac gccgtaagcc 2964481 gacatgagaa agtggcggcc gaattcatcc atgacgtaac tgccattctg cgcgtaatac 2964541 gtcattaact gttcaagcac gttcattgac ctcttccccc tttcacgatt cgaaatagcg 2964601 atgtttttct aaatattcct tggcaacgac agacggttct ttgagattgc cgtcgacttc 2964661 atagttaagc tcctgcatcg tggctgtgtc gatttttccg agcattttct tgatgatgcc 2964721 ttcaagttca ggatgttctt tgagcacctt ttccggaaca accggagagc agtcgtacgg 2964781 cgggaaaaat tgtttatcat cctttagcat tttgagacca taggacttga ttcttccatc 2964841 ggttgaatac gcaagcacaa tgtccatttt tccgcttttc accgcgtcgt acacaaggcc 2964901 gatctgcatc ggatacgtgc cgccgaatgt catgccgtag gttttcgtaa aatcctgata 2964961 gccgtttcct ttgagcttca tccaatagtt atcaacgccc agctttaatt gcggcgccca 2965021 ttttttaacg tctgatacgg tctctaaatg gtattggtcg gccagctcct tgctgactgt 2965081 aaaggcatat gtattatcaa acccgtagga gtcataccac tttaaatcat atcttttttt 2965141 aaactcccgc tgagtaagcg ccagcgcttt gtccggatct ttttcaggtt ccattctcaa 2965201 cgtgcctgtc agcgcgtctc ccgtatatct tgtggccgca atgtcgattt ccccgttcat 2965261 taaagcctgc tgctgcaccg cgttggagcc aagattttta atcgttgttg ttttgagatc 2965321 agtatggtgt tcgatcaact ggccaagcat gctggcgatg atttctgatt cgctcatgct 2965381 ttgcgcgccg attttaatgg tctggtctgc agcagcgctg agaccaggaa gcgaacagcc 2965441 gctcagcgtc agcgttgccg caagtgctaa acctatcatt aatttgagat attttctttt 2965501 catgagccgc ctccttatga caattccttc aatctctgca tgccggcagg tgtcagtttt 2965561 cgttcagcaa ctgccagcac ataatcaatc acaattgcca atatcgtgac aggtaccgcg 2965621 cccccgatga tatattccgg ctgatataaa ttcagtccga taaaaatgta atcacccaat 2965681 ccgccgcctc cgataaagga agcaagcgtg gcccagccga ttaagtaaat cgtcgatgtt 2965741 ctgattcccg ccatgatcac tggtgcggca agcggcagct ccaccaagcg gacttgttca 2965801 gccggcgtca ttcctattcc tttaccagac tcgagcagat ttttgttgac gccgcgaatg 2965861 ccggtatacg tgttgcgaag aatcggcaat acggaataga aaaacaaagc cacaatggcc 2965921 ggaaccttcc ctacaccaag gagcgggata aaaaaagcga ggatggccag actcggcagc 2965981 gtctgaatga tattgacaat gccgataatg gtgccggctc cttttttcat tctggtaagc 2966041 acaaccccga gggggacggc aaccagcaca cctaagatca cagcaatgag cgatatcgta 2966101 atatgctcgt atgttttata aagaagctct cccccattgg tttgcaaaaa ttgaacaata 2966161 tgatgcatga cttatcgccc ctccctatga caatgctgcg agctgctttt cttctcccca 2966221 gagggagtca tacacgatgt cgaccagact tgccctcgtc acaattccga tcaggcgtcg 2966281 gtcttcatcc acaacgggaa catatttgac accccgtttt aaaattttgc ggaccgtgtc 2966341 gcgcagcagt gtgccgccca gtactgtgta tatatcttca tgtaaaactt cactgacgag 2966401 attggccttt ttccggcatt gatcaatgat ttcaacatcg acatagcctt gcagaacgcg 2966461 ctcgtcattg acgaccagca atgaatcgac ccgttcctgc ctcatcagct gaatggcctc 2966521 agaaagcgtt ttatccgcgg tgatcgttac aggctgtgtg ttcataatct ggtcaacccg 2966581 ttcaacatcc gggctggatg actgaatcag ccgctccttg ccgataaatt cctcaacaaa 2966641 ttcgtctgcc ggatttctta aaatgtcatc gggcgttcca acttgaacga tttctcccgc 2966701 ttttaaaatc acaatccggt ctgccagctt aatcgcttca tccatatcgt gggtaacaaa 2966761 tacgatggtt ttatgtaagg ttttttgcag ttttttaaat tcttcctgga gggaatccct 2966821 cgtaatcggg tcgagtgccc caaacggttc atccattaag ataagcggcg gctccgcggc 2966881 aagtgcccgt aatacaccaa ttcgctgctg ctgccccccg cttaattcat gagggtaacg 2966941 gtctacatat tctggcccca tatcgaccaa ttttaaaagc tcacgcgccc gctctttccg 2967001 ctgctgctcc ggccatttca gcagttttgg gacgagtgag atattctgct gaatggtcat 2967061 atggggaaac aggccgatct gctgaatcac atagccaatt ttgcgcctga gctctacagg 2967121 atcctggtcc atgatgtttt cgccgtcaat gaaaatcttc ccggcggaag gctcaattaa 2967181 tcggttaatc attttcattg ttgtcgtttt tccgcagccg ctcggcccga taaagcagat 2967241 aaattcgcct tttgcaatct taagatttac gttgttcacg gcttttttgc cgcccttgta 2967301 tgttttcgag acattttcta atgtcagcaa acatcgcacc tccaaaatta agtttattca 2967361 atttgttcag tttaaattta atttttcaga caattgaatg cttcccatta tagaataaag 2967421 tttataaaat aaaaagttta caatttgttc atattattta taaagtatgt gtaaacgctg 2967481 atttacccgc attgacgtgt gttgatctcc ttattgctcc aatttcctgc caaattctct 2967541 tttgacagca ttttcgccgt atcaaaaatg tggtatattg acatcggaat tgttagctga 2967601 aaggatgaaa ccgttggaga aagatccgtt aacgatcatt gaacaagccg aggaccattt 2967661 tatagaaaga atcgcggaaa acatgcatgc atttggaatg ccctctaccg tcggacgagt 2967721 gctgggcatt atttatatga atcgaaaacc gatgacgctt acggaattat ctgaggccac 2967781 cggcatgagt aaaacacgta tgagccaggt agtgcgggaa atgcttgatg ccaacattgc 2967841 cgagaaggta ttcgaaaaag gcgtgcgaaa agatttatat gaggttgagc aggactacta 2967901 tcaaacattt atcacgctgt tttcagccac ctggagcaaa gtcgtcagca aaaacaaaat 2967961 gatgcataaa aaactcaatc gggagctgct tagcgtgttg gatgaagagc ttactcctga 2968021 agcggaagaa aaagtgaatg agctgctgaa ggaattaaag gaatggctcg attattataa 2968081 ttggctcagc cgtttgattg agttttttga gagcgaagac atttttaaat atgtgccgaa 2968141 gccgtaaaaa gttcccaaat tcaattctgg gaactttttt aagtccaatc caaatggttg 2968201 aatatcaaac ttcgagctcc caacgctgga aaatatgttt aacagatact aacacatgtt 2968261 gtttatttaa aaaaaccacc tctgttgtat ttaaatagag gtggtttttc tatcagctat 2968321 aataaaattt ccttttttct ttttaatcgg gcttaatgct cgttcaagcc agcccatgac 2968381 caaatcggca atcaccgcca tcagagctgt ggggatcgct cccgctaata taatcgcggt 2968441 tccgtttgtg gcgtttgatc ctctgacgat gatgtccccg agaccgccag caccgacaaa 2968501 tgtcccgatg gccgtaatgc cgatcgcaat gacaagcgcg gtgcgcaggc cggccattat 2968561 gacagaaagc gcaagcggaa gctcgaccat ccgcagcact tgaaattttg tcatccccat 2968621 tgcttttccc gattcaagat aggcgtgctc aatactgata atccctgtat acgtatttct 2968681 gataatcggc agaagagaat acagaaataa tgacaatatc accgtattag cgcccagccc 2968741 catgacaagc atcagcacgg cgagcatggc gagagccggg atggtctgaa tgacattcgt 2968801 gaccgcaaaa acccatccgc ttaatcttct gtatctggct atcaggatgc cgagcggaat 2968861 tccaacaatg gcggcaaata aaacgccata caccgacatc agaaaatggc ggtaaaattc 2968921 ctgcagcacg taaccgccgt tttgcgaata gtatgtgcca agctgctgta gtacttccat 2968981 atgatccacc tcttttctta gtcaaaataa tgatgtttct ctaaaaattc ctttgctacg 2969041 acagacggct ccttcagctt gccatccacc tcataattaa gttcctgcat cgtttccgtg 2969101 tcgatttgcc caatcagctt attgatcaca ccttcaagtt ccggatgctc cttaagcacc 2969161 ttttccggaa tcaccggtga acagtcatac ggcggaaaga aacgcttatc gtcttttaag 2969221 attttcagat catatgcttt aatccgtcca tccgttgaat aagccaaaac cgcatccatt 2969281 ttcccgtttt tgactgcgtc atagactagc ccgatctgca ttggataagt tgtgccgaac 2969341 tcaaagccat atgtgctgac aaagccttta tacccgtcgc cttttcgttt cagccaagca 2969401 ttgtcgacgc ctaatttata ttgggaagca tttttcttca ggtcagacac ggtgttaata 2969461 tgctcctttt ccgcaaactt ttttgttacg gtgaaggcat atgtgttatc aaagccgtag 2969521 gaatcaaacc atttataaga aaagcgcttt tgaaactcgt tctgcacaat gttcagcgct 2969581 tttttcggat ctttctccgc ttccttgccg agggtgcttg ttaaatctgt tccggaatag 2969641 cgcgtggctg aaatatcaat gtcaccgccc agcatcgctt ggtgctgaac atagtttgag 2969701 ccgaggtttt tcactaaagc agtattcaaa tctgtatcat gttcaataag ctgcgcgatc 2969761 atattcgcta caatttctga ttctgtcatg ctctgcgccc cgattttgat cgtatcgtca 2969821 gaagcgccgc ctagacccgg cagagagcag ccgcctagca gcatgacaaa gacgagagca 2969881 aacgcgccaa gccatttgat ttttgtcatt ttcaacagtg ccaactcctt acgatacttc 2969941 cttcatccct tgcaagcctt tcggcgtcac ctttcgttct gtcacagcca gaacataatc 2970001 aataataatt gccagaattg tgacaggcac ggcaccgcca atgatatatt caggctggta 2970061 taggttcagt ccgataaaaa tatagtcccc gaggccgcct cccccgataa acgacgcaag 2970121 tgtcgcccag ccaattaggt agatcgttga tgtgcggatc cccgccatga tgatgggaat 2970181 cgccagcggg atttcaacga gccgaatctg ctcccagccg gtcatgccaa ttcctttccc 2970241 cgattccagg aggtttttat ttacaccttt aatgccggta tacgtattgc gcaggatcgg 2970301 cagtaccgaa tagaaaaata aagcgacaat cgcaggcact tttcctacgc cgagaagcgg 2970361 aataaaaaag gctaaaatcg ccagactcgg cagggtttgc acaatgttta cgaaaccgat 2970421 aaccgcacct gcgccttttt tcattctggt aagagcaacg ccgagcggca ctgcaacgat 2970481 aatgcccaat acaacggcta tgagtgaaat atataaatgc tctcctgttt tatacagcag 2970541 ctctccgccg ttcgtttgca aaaaagtcat catttgattc atcttaaaag agctcctccc 2970601 ctggtcagat cgtcatgagc tggttttcct cgtcgcccca aatggaatcg tatacgatat 2970661 caacgaggct cgctcttgtc acaatccctg ctaaatggtt ctgttcatcg accaccggaa 2970721 catacttgat cccctgcttc aaaatttttc ggactgtatc gcgaagaagc gccccttttt 2970781 gaacggtata tatatctgaa cggtatacat cgccaacgat gctcgctttt ttgcggtttt 2970841 gatcaatcat ttccacatca acatagccct tcagcacgtt ttgccggtcc acaacgagca 2970901 gcgagtcaac acgtttttct ctcatcagct gaatcgcctg agaaagcgtt ttgtccgcag 2970961 ataccgtcac cggcgttctg ttcatcattt gctctacccg ctcgatatcc ggtcttgact 2971021 gaatcaggcg ctctttcccg ataaattctt caacaaactc atttgccggg tttcgaagaa 2971081 tctcatcagg tgtgccgact tgaacgattt ctcccgcttt taatatcaca atcctgtcag 2971141 caagcttaat cgcttcatcc atatcgtggg ttacaaacac aatcgttttg tttaaggttc 2971201 tctgcagttt tttgaattct tcctgaaggg aatcacgcgt aatcggatca agcgctccga 2971261 acggttcatc cattaaaatg agagggggtt ccgctgccag ggcgcgcagc acgccgattc 2971321 tctgctgctg tccgccgctg agctcatgcg gataacggtc taaatactct gggcccatat 2971381 ccacaagctt taacagctcg cgcgcccgtt ctttccgttt ttcctcaggc catttcagca 2971441 gctttggtac gagtgagatg ttctgctgga tggtcatatg ggggaacaaa ccaatctgct 2971501 gtatcacata gccgattttt ctcctcagct caaccgggtc ctgttccata atattttctc 2971561 cgtcgataaa gatccttcca gacgatggtt ctatcagtct gttgatcatc ttcatcgtcg 2971621 tcgtttttcc gcagccgctc gggccgataa aacagataaa ttcacctttt gcaatatcta 2971681 aatcaatgct gttcacagct tttttgccgc ctttatatac ttttgacact tgttccaatt 2971741 tcagcaatcc gtgcacctcc gcaggtttcc tttaaatttt ctgaaaagta taatccttat 2971801 tatagtttga actttgtaaa ataaaaagtt tacaatgtgt tgaaattata tgttatttat 2971861 agattattta ttgttatgac cgagacggaa agggtgttct tacaattact ccggatacct 2971921 cccacttcct ctgcattcag ctattttcaa caccaggaag aaatatgata tattgacacc 2971981 atcaattgcc atttgaaggg atgatcagct gtgaaaaaaa ccgctctcga catcattgaa 2972041 catgctgaag agcatctcat tgagaagatt gccgaaaata tgcatacgtt tggaatgcct 2972101 tcaactgtcg gacgtgtgct cggaattatt tatatgaatc gaaaaccaat gaccttaagc 2972161 gagctctctg aggcaacggg catgagcaaa acacggatga gccaggttgt ccgggaaatg 2972221 atcgatgcca atatcgccga aaaggtgttt gaaaaaggcg tacgaaaaga cctttatgac 2972281 gtcgagcagg attattatca aaccttcatt tctttatttg cggcgaattg gacaaaggtc 2972341 gtgagcaaaa acaaagtgct gtataaaaaa ttaaaccggg agctgagtga tcttttacaa 2972401 agggacgggc ttaccccgga agcggaagag aaagtcaatc agctgctgaa tgaattaaaa 2972461 gaatggcttc attactatga ttggctgagc aggttgattg aattttttga gagtgaggaa 2972521 gtctttcggt atgtgccgaa aacaaaagaa tgcagctctc taaaataaga gagctgcttt 2972581 ttgcatcatg aagttaagac cggaaacatg cctttcagcc cggcaccaat catcccgacc 2972641 gcaaccacgg ctaagattaa tcccatcagt ctggtaatca cattcatctc ggtttttccg 2972701 agtttgctgc tgataaaagc agaatagtgg aaaaagagaa aggtcagggc aataacggcg 2972761 gctatgccga tcatgacagc cgcataatga ccaatgccgc tatgtccggc ggaaaggctc 2972821 atcactgttg caatcgttcc gggcccagca atgatcggaa tggataaagg tgtgactgat 2972881 atatccgctt tttccttgct ttccttatgt tcatcatggt gaagagattg cacgtgcgat 2972941 tctttcgcat tcaatagatt ataggcaatg ccgaaaatga atatgccgcc cgccactcgg 2973001 agcgcgtgaa tgttgatatc aaacagttta aagataagat gaccgaaaac caaaaaagct 2973061 gcgagaataa aaaaggataa aatagctgcc ttccgggcaa tcgcttttct ttccgctgca 2973121 gtatagcctt ctgtcagcgt cagaaatatc ggtacgtttc cgatcggatt cgatactgcg 2973181 aataaagaaa tgaagacgtg aacgataaat gagaacatca tatacctcct tgttgatagt 2973241 ctctgcacag gaaatagaat gattctccac ccttttaccc ggaggcgatt tcccggtaaa 2973301 cctttatagc ctgtcagaaa cgcgccatgc tacaatgaag tgacaaattg aataggaagg 2973361 acgtatacag atgttcaaaa aaattgcggc agatgccttg ggcttatctg atatcggaaa 2973421 aattatcgaa cctcaggact atgacaaaac agacgcagat gactatgtca tgcatgaaga 2973481 taatgagaaa atttatttct tgattaaaac aaaagcagac gagtattgct ttacgaacct 2973541 ggccctgatc catgtggacg gcgaacgcgc cacttcctca aaacgaacgt tgaaacgcta 2973601 tccttattcg caatataaaa tctctgacgt ttttcttgaa actgccggaa aagtggattt 2973661 ggatgttgaa attaagttca agctgggcgg tgaacaattc gacattgatg tccacaaaga 2973721 ccagattgaa aagttaaaag acctttataa agcactgctt cgcatcgctg aaacaaccta 2973781 tgaaaatgac attttaatca atcaagcgga gcaaagctta gataaagcag tgacgattct 2973841 tcaccatacc cgccctgagc acgtcaatat tgaaacgcaa tacaaagagc tgaccgaatt 2973901 cggattcact tggctgacat ccgttcgctc gcagtatcat attaaggatt ttggggatgt 2973961 atttgagaaa tatattaata actagataaa aaaagacaca gctgctatcg tgctcgtgtc 2974021 tttttttgta tgaatattga ttactttaca acttttttct tttataataa aactattagt 2974081 ctattttccc tatattacag ataaaggagt tattttatgt attgtcctca atgcggccat 2974141 caaacagatg gcggaaattt ttgtgagaaa tgcggatcac cgctccccgg tcaatcaggc 2974201 caccagcatg cagctcaaac tggagccgct gcaaagcaag cagcaaaaca gttcggttca 2974261 tttgtcttat ccgtcctgaa acgcccttat caggaatgta aagcaacagg cggagaacag 2974321 ctgatcagcg caatcattac gatggttctt ttcagtttgc tgaccccttt gatgttttat 2974381 attctttttt cagacggtcc cggaagcgta agctttacag caatcttctt agagccaacc 2974441 atttatttta ttttatttct atttggcctg catgcatgca tctttttcgc cctgaaaatc 2974501 gcgggaaacc aagtgtcttt caaggattca ttctcaagat tcggagcatt tcttattcct 2974561 tttacggcta ttttgattct tgcccttttc ttctttttat tacatacaga catttgcttt 2974621 accatattag ccgttggttt aatcggtgca ttcttcgcca ttcctcctgc gatgctgagc 2974681 agttaccagc attcatataa agggaaggtt gatttcattt actcaacgat tgtgatttat 2974741 ctgatcatct gcgttacatt tcagcttatt atcgaacact atgtcaaaga aattttccgt 2974801 tatatgctct tttaaaaaca accccatcac ctgctggtga tggggttgtt ttattgaata 2974861 gacgttaagt aaattcttcc gttcttcact acgccggtgt aggtccagtt atatgttctg 2974921 agctttggac tgccgcctga ttttgtgata tagaattctt catacgtctt aatcgtgata 2974981 gccgacccat tttggctcca gcttttcact tcatagttat taaagtcttc tgttgtcccc 2975041 tctttattta atttcgacac gagatgctgc tggtcggaat aaagggaact gcctttttca 2975101 aggctgtctt ccatcagtga gaaattattt tgattcacgg catctgcctg actttgcaga 2975161 taactgccca taaataatgt cacttgttca tctgtaacat cgccgcttgc agagctttca 2975221 ctgcctttgt ttttcgagcc agcccaggcg gaagtgtatg tctctggttt atcatttttg 2975281 attttcttta tatttgtgcc tgcagattcg aatgttgatt ctgcatcttc gaaaatccac 2975341 tttttctgtt ttttatcata tgaaagaaga tattcataac tcggactgtc gtcagtcatt 2975401 tcagactttg tatagtcgtt atacgaagaa gactggtgaa gttcttttcc tgttaccgat 2975461 acctgccacg ttccgtcgtt tttctgagag agggcaaatg tgtccaggtc aaaatcagtt 2975521 tccaagtatc tatcttttaa gtatgaatcc gcgcttttca tagaatcgac ggtgtccttc 2975581 gtctccgcct tccaattggc acttgcctct gtcatctggg ctgtattccc atcagataga 2975641 gctttggagt attgttttgt tgttttgaca attgtgttca taatctgttc ctgtgtatct 2975701 tgatcaggaa ttaacgttaa ctccatttct ttatcatcga tcggaacgcc ggcagttttt 2975761 gtttttcccc acggaaattc tgcctcgact gaagctgtca ttgatccatc tgtcagcagc 2975821 ggaccatatg ttacggattt gaacggatct ttatgaattg atttaccgtt aatcagcaaa 2975881 tctcccttcc cgctcttgat gtcattcgct aagctgaatg tcacatcgtc tgcttccaat 2975941 gagagatcaa cacgaaagct gctatcgcca atcgcctgaa tgtcttcctt tttcacaagg 2976001 tcaacgacat cgtttttcag tttggctgag actgtatatt cgccgggaat gtacggacca 2976061 agggtttgtg cttgatctgc tttctttaca gatccggctt cctctttatt gacatataga 2976121 tcggtatttt tataattgct gctcacttca aaataaacag gtgctacctt taagtcataa 2976181 tggtcaaata ccagcaggct tttcccgtct ttttccgcat atacgatatc cttctgggct 2976241 gtttcatcac gcagcgatgc aaaaagttca tcttttttgt ctggatgatc cttcaaatat 2976301 gtaagaaacg gttttacatt atttttagtg agtttaagat tgtcatttac cggtgtaagc 2976361 agagtcgcga tttggtcctg atccccatca tttacggcct gttcaaactt gtctactaac 2976421 ctatcctttg aagtaaaata cgctccggtt ttatatgcgg cgaataatat aacgcacgcc 2976481 gcggcaatgc tgctccataa aatgatggtt ttcttaggga tcggttttcg cggagcctgc 2976541 ctcgtttctg cagtgctagc tgtttcttga tttgcctgtt tgctgccccc tccgatcggg 2976601 gtgccgcatt gtttacaaaa cttggctcct tcattattct gggagccgca attcttacaa 2976661 aataacatga ctttcctcct attctactaa tttgataaca tttactgctt ttcatatttt 2976721 ataataaaac agaatgaaat tgggaacgaa tgaaaaaatt aaatgtctat cagactaaaa 2976781 aggtggaatg aatatgcaaa agctcaggat tgaattagga gaagaaacaa atgacgaatt 2976841 atatgatcta ttgctgctcg ccgatccatc gaaagacatt gtagatgaat atcttgagag 2976901 gggagaatgt tacacagctt gggccggtga tgagcttgca ggggtttatg tattgctaaa 2976961 aacaaggccg caaacagttg aaattgtaaa tattgcggta aaagaatctc ttcagaagaa 2977021 aggctttggc aaacagcttg tacttgacgc catcgaaaaa gcgaagaagc tgggggcgga 2977081 cacgattgaa atcggaacgg ggaattcgag cattcatcag ctttccctct atcaaaaatg 2977141 cggattccgc attcaggcga tcgaccacga tttctttctc agacattatg atgaggacat 2977201 ttttgaaaac gggattcaat gccgcgatat ggtaaggctt tatttggatc tctgaaagca 2977261 taaaaaagcc gccgagagaa aatcccggcg gtctttttat tacttgttta agttgtagaa 2977321 agagttgata ccgtggtatt gagcagtttc agccaactga tcttcgatgc gaagaagctg 2977381 gttgtatttc gcaacacggt ccgtacgaga cggagcacct gttttgattt gtcctgcgtt 2977441 tgttgccaca gcgatgtcag cgattgtgct gtcttcagtt tcaccagaac ggtgagagat 2977501 aacagctgtg tagcctgcgc gtttcgccat ttcgatcgca tcgaatgttt cagtcaatgt 2977561 accgatttgg tttactttga tcaggataga gttgcctacg ccgtttttaa taccttcaga 2977621 aagttttttc gtgtttgtaa cgaagaggtc gtcaccaaca agctgaactt ttttgccaag 2977681 acgctcagta agaagcttgt ggccttccca gtcgttttcg tcaagtccgt cttcgatcga 2977741 gatgattggg tatttagaaa caagctcttc ataccagtca accatttcag cagatgtttt 2977801 cacaacgcct tcgccagaca gatggtattt gccgtcttct ttgttgtaga actcagaaga 2977861 tgcagcatcc atagcaagtt taacttcttc gccaggtttg aagccggctt tttcgattgc 2977921 ttcaacgatt gtttgaagcg cttcttcgtt agaaccaagg tttggagcga atccgccttc 2977981 gtcacctaca gcagtgttta agccttttgc gcttaatact gatttcaggc tgtggaagat 2978041 ttgagcgccc atgcgaagtg cttcacggaa gttaggagca cctacaggca tgatcatgaa 2978101 ttcttgaata tccacgttgt tatcagcatg ctctccgccg tttacgatgt tcatcatcgg 2978161 tacaggaagc gtttttgagt tgaatcctcc aaggtattgg taaagaggaa tctgtaagaa 2978221 atcagcagca gcacgcgcac aagccataga tacgccaagg attgcgttcg caccaagttt 2978281 gcctttgttt tcagtaccgt caagctcgat taaaagctga tcgattgcgt tttgttcagt 2978341 tacatcaaag ccaagaagct ctggagcaat gatttcgttt acgttgttaa cagctgttaa 2978401 cacgcctttt ccaaggtaac ggtctttgtc gccgtcacga agctcaaccg cttcgtattc 2978461 acctgtagaa gctccgcttg gcactaatgc gcggccgaaa gctcctgttt ctgtatatac 2978521 ttcaacttca actgttgggt tgccgcggga gtctaatact tcgcgtgcat aaacatcaac 2978581 aatgtatggc atgagttttg tctctccttt tgattttcaa attatttttg aattaaagat 2978641 gttcctgtca tttctttcgg tttttcaaca ccaagaaggt ctaataacgt tggtgcaagg 2978701 tcgcctagga ttccgccttc acgcagcgta atgccttctt tcgttacaat cacagggact 2978761 gggtttgttg tatgcgcagt gtgcggttcg cctgattctg taatcagaat gtcagcatta 2978821 ccgtgatcag cggtaatgat agcgtgtccg cctttagcaa ggatcgcgtc aacgacttcg 2978881 cccaagcatt cgtccactgc ttcaattgct ttaattgttg gttcaaccat tccggagtgg 2978941 ccgaccatat cagggtttgc gaagttaaga atgatcgcgt catgcttgtc agcttcaatt 2979001 tctttgacaa gcgcgtcttt cacttcatac gcactcatct caggcttcaa gtcatacgtt 2979061 gcaactttag gcgagttgat gagaatacgc tcttcacccg ggaattcagc ttcacggccg 2979121 ccgctcataa agaacgtgac gtgcggatac ttttcagttt ctgcaattcg aagctgtttt 2979181 aacccgtgct gagataatac ttctccgact gtgttatcaa gatttatcgg tttaaacgct 2979241 acatagccgt caactgtttc actgaagtga gtcaggcaga cgaaatacag gttctttgga 2979301 taattctcgc cgcggtcgaa gtcacggaag tctttgtttg tgaacgtgtt ggaaatctgg 2979361 atggcgcggt ccggtctgaa attatagaaa atcacagaat cgccgtcttg gattttcgca 2979421 acaggctcac cgttttcttt tgtgatgaca gatggaatca cgaattcatc gtagatacca 2979481 tttgcatatg aatcatcaac aacatccagg gcgctgcggt aagatgggcc ttcgccgtac 2979541 gccattgcgc ggtacgcttt ttctacacgg tcccagcgtt tgtcgcggtc catagagtag 2979601 taacgtccgg aaatgctggc gatttcacct acaccgattt ccttgatttg atcgttcaac 2979661 tggttgatgt acgttttcgc tgtctgcgga cctacatcac ggccgtcaag gaagccatgg 2979721 atataaacct ttgtcagccc ttcttttttc gcaagcttta acagtgcgaa taaatgattg 2979781 atatggctgt gcacgcctcc gtcagataaa agaccgaaca ggtgcaaggc tttgttgttt 2979841 tctttcgcgt tgctgatcgc gtcaaggaat gtttgattgc gttcgaactc tccttcacga 2979901 atggcaacat ttacgcgtgt taagctttgg tacacaatac gtcccgcacc gatatttaag 2979961 tgacctactt cggagttccc catttgccct tcaggaagac ctacagcctc gcctgaagca 2980021 gtcaaagttt gatgaggata ctggttccaa tagcggtcaa aattcggttt tttcgctaaa 2980081 gcgactgcgt tccctactgt ttcgttacgt aatccgaacc catcaagaat gatgagtgca 2980141 gctggttttt tactcatatt gaccttcctc caataattga acgaatgact gtggctcaag 2980201 gctcgcgccg ccgaccaaag caccgtcaat atcggactct gccatatatt ctttaatgtt 2980261 tgcaggcttt acgcttccgc catattggat gcgaagcttg tctgcagctt cttggctgaa 2980321 gctttcagcg acggttttac ggatatgcgc acacacgtca ttcgcatctt tcgctgtaga 2980381 agatttgcct gttccgattg cccagattgg ctcatacgca ataacagaag cagcaacttg 2980441 ttcttcagaa agaccagcaa ggcctttttt cacttggtca gcaacaagat catttgtttt 2980501 gccggcttca cgctcttcaa gcgtttcacc tacacagatg atcggcacaa tgccgtgttt 2980561 gaaagctgcg tgtgcttttt tgttaactgt ttcatcagtt tcagcgaaca tttcacggcg 2980621 ctcagagtgg ccgatgacgc agtagtcaac gccaaggtct ttcagagcaa ccgggctgat 2980681 ttcgcctgtg aacgcgccgc tttcttcgaa gtgcatgttt tgagcgccga cttttaggtc 2980741 agtgcctttc acagcagaag caagcttttc taagaaaagc gctggcgcgc aaacaacagc 2980801 ttcagctttg tctgctgctg gaatggaaga tttcacttct tcaacgaagc tgacagcttc 2980861 gccgagtgtt ttgttcattt tccagttacc ggcgataatt ggttttctca tctgttccac 2980921 ttccttatag cagttttgag attatttatc gttcagtgca gctacccctg gaagctcttt 2980981 gccttccata aactcaaggg atgcgccgcc gcctgttgag atgtggctca ttttgtcagc 2981041 aaggccgaat ttttcaaccg ctgccgcaga gtctcctccg ccgatgacag agtatgtatc 2981101 tttcgcctct gccaatgctt ccgcaaccgc ttttgttcct tgagcgaaca agtcgatttc 2981161 gaatacgccc attggtccgt tccacacgac aagtttgctg tttttgatga cgtcagcata 2981221 cgtttcgcgt gttttcgtac caatgtcgat tgcttctaaa tcactaggga tttcagagat 2981281 cggcacaatt ttcacgtttg catcgttaga gaaatcatct gcaacgagta catcttcagg 2981341 catgtagaag ttaacgcctt tttctttagc gcggtccata aatgatttcg caagctcgat 2981401 tttatcctct tcaagaagag atttcccgac ttcatagcca agcgctttta cgaaagtata 2981461 agcaagacct ccgccgatga tcaggttgtc tactttatca agaagacttt cgattacacc 2981521 gattttgtct tttactttcg ctccgccgat gatcgctgtg aacgggcggt caggattgga 2981581 aaccgctttt ccaagtacat caagctcttt ttccattaag aaacctgcaa ctgctggcag 2981641 atgctcggca attccagctg tagatgcgtg agcacggtgg gcagcaccga atgcgtcatt 2981701 tacatataca tctgcaagct cagcaaatgc ttttgcaagc tcaggatcat ttttctcttc 2981761 accaggatag aaacgtacgt tttccaatac aagaacgtct ccgtccttca tctcagaaat 2981821 ttgtgctttt acagcatcgc cgtatgcttc atccgctttt ttcacttctt tgccaagcag 2981881 ttcgccgaga cgtgcagcga caggagttaa acgaagctcc tcaaccactt cgcctttcgg 2981941 gcggcctaag tggctcgcaa gaaggacttt tgcgccttgg tctgcaaggt gtttgattgt 2982001 tggaagcgca gcacggatac gtgtatcgtc tgttacttcc ccgtctttca ttggaacgtt 2982061 aaagtcaacg cggcagaata caactttgcc ttttacgtcg atgtctttga gagttttttt 2982121 attcatgcct aggagatcct ccttcaaaat ggtttgcata cagcacgaaa aacgtgaaac 2982181 cgtctgttca agcgataact ccgctagggc agatcgcagt ctttttcggc acagggcagt 2982241 tcgtctaaaa gccagggcag cggccttagg cgaaagcgcc ggcaaagctg cttaaaacgc 2982301 ggtcgtttct ctatcacaga gcgttttctg aaagccggtc ttcatggaaa aagggaaagg 2982361 gagtccgtcc ccttcccttg tccgctttca ttatagcgct tctattcgaa agaaccaagt 2982421 caggtccttt ttcagctata aattaaagac ctttttttgc gatgtaagct gcaaggtcaa 2982481 caacgcggtt agagtagccg ctttcgttat cgtaccaaga gattactttt accatgctgc 2982541 cttccataac cattgtagaa agagcatcga ttgtagaaga gtttttgttt ccgttgtagt 2982601 cgccagaaac taatggctct tcgctgtagc caaggattcc tttaaggtcg ccttcagccg 2982661 cttctttaag agctgcgttt acttcttcag ctgttacttc ttggttcagt tcagcaacca 2982721 agtcaactag agaaacgttt ggagttggaa cacgcattgc tccaccgttc agtttgcctt 2982781 ttagttcagg aagaactaga gaaactgctt tagcagcacc agttgatgtt gggatgatgt 2982841 tttcagctgc tgcacgcgca cgacggtagt ctttgtgcgg aagatcaagg atttgctgat 2982901 cgtttgtgta agagtgaaca gttgtcatca taccgcgttt gatgccgaat ttatcgttaa 2982961 gtacttttgc aaacggcgca aggcagtttg ttgtgcaaga tgcgttagag ataacatcgt 2983021 ggttagccgc atcgtattta tcttcgttaa cacccataac gattgtgata tcttcttcgt 2983081 tagcaggagc agagatgatt acttttttcg cgccagcttc taagtgtttc gcagcgtctg 2983141 cgcgttttgt gaagaaacca gtagattcaa ctacgatttc aacgccttgt ttgccccagc 2983201 taagtttagc aggatcgcgt tctgcagaaa cttcaattgt tttgccgtta acaacaaggt 2983261 tgttaccgtc aactgaaact tcagcgtcta attttccgtg tacagaatca tattgtaaaa 2983321 ggtgagccag catgttagca tctgttaaat cgttaaccgc tactacctca acttcaggat 2983381 tgtttaatgc tgcgcggaat acgttacgtc caatacgacc aaaaccgtta ataccgactt 2983441 ttactgccat gattgtttcc tcctttaaat aagtgagaga tatttatatt gagggattat 2983501 tcatccctta ataacttctt tgcggctcct tcgtctgtga cgagaaccgt gttgcgtggc 2983561 tttttaaagt aagcctcgat cgcttcggct tttgatgatc cgcccgctac cgcaataata 2983621 tcggggatgg cgtctatgtc atccagctgc attccgacag aatgcacttt gtgaaccact 2983681 tcgccgtccg cgttaaaata gtagccgaac gcttccgtca ccgcgtcgtt atcatctatt 2983741 ttctttaaat cttctaaagg cgtgtttctg cgctgagcca tagttttagc ttcgccgatt 2983801 ccgtgaacca gcatactcgc tgatttaatg gtgttcagca cctctttgac agaaggctct 2983861 tcaataatag atgaataggc gccttgtgac agctgtcccg gaacaaacaa aagccggtaa 2983921 gtgcctgaag ccttctccgc catatgcgcg catatggtgt tcgcctggtt tttcacgtct 2983981 tcgcctaaac cgcctcttgc aggcacaaac aaaagctcgc ggtttttaga atccggcgtc 2984041 atcatttcgg cgacagcttc aattgtcgta ccgccagtta cagcgacgat atttttgcct 2984101 gaaaatcttt ttttcataca tgcgacagcc gctcttccca tttctttttt gacccatggg 2984161 gattgatcgc tgtctccgga tacgataatg gcatccttta gatttaaacg ttcttttaat 2984221 gtcttttcca aaagagtcaa acctaaaaca tctttcatcg tatcttccaa aacagaaagc 2984281 agttcatagc cctcttctgt caatgtcatg ccgtttgtct taatatcgac caggttctgt 2984341 tcctttaaaa actgaacctc gcccctcagc acacgctcgc tgattccgag actggcagac 2984401 aggcttcttc gcccgatggg ttctgtcagc ctgatatact gcaagatttc aaacctcttt 2984461 tgcataacga gcagaagatc aggcaataat tttttttgag cttgtattaa ctggttcatg 2984521 actcaaacgt tccttccttt tttgctggac attatatgtc ccgctatgac aaaaaacgtc 2984581 ccgtcatagc caaaaaaaat catttctgct ttctttaatt attttaacag ggtggaattg 2984641 tttattcaac tgttaagagc caattcatcg acaatattcg cagagttttc atgccgcgtc 2984701 gttttatcca gcaatatttt atcctatata tctttatctt atacagaaag cgccaaatgg 2984761 tgcatcccaa tataaacagc ccttcccgta gaaagggctg tttcattaaa gcgttttcat 2984821 tttatccaaa gcttttcaat ttcctcgagc gatttgttct tcgtttctgg acagatcgta 2984881 acgacaaaca ggaaacaaag gatgttaatc accgcaaaga tccaaaatgt ataggcgagc 2984941 ccgaaagaat cgatcatcat tggcacaaac tgtccgatcg cccagtttgc tccccataaa 2985001 aagatggtcg caatgcccgc ggcccgcgca cgcagatggt tcgggaagat ttcagaaatc 2985061 ataatccatg tgatcggtcc gaccgagaca cagaaagcag cgacaaaacc taatataagg 2985121 acgatcatca tgatcccgct tgttaactca aaataaaacg acgtcccgat taaaatcata 2985181 aaaatagcca taaaagcaga accgatggac atcagttttt ttcgtccgac tttatcaatc 2985241 agcaacaccg caataacggt aaaaataact tctacaaccc cgacgataca agtcgtcaca 2985301 aatccggcgt tttgcccgaa tcccatcatt ttaaagattt ccggcccgta gtaagtaatc 2985361 gcgttcatgc cgatgacttg gttaaacagc gccagcagga ttccaatgac aagcgccttt 2985421 ctgagacccg gcttaaacag ctgggagagc gaccccattt gttctatttt taaagagttc 2985481 tcaatgttct ttaattcttc ttttgcaaca gtttctccat taatacgtgt caggatcttt 2985541 aaagcttcat ttgttttgcc cgctttcgcc agccatctcg gactttccgg gacgacgagc 2985601 aggacaagga aaaaaatgac ggatggcacc attccataag caagcatcca tctccagccg 2985661 gtgtgcacgc cccattcgta tgttccggac cgctgcacag ctagattaat aaagtatgtt 2985721 gcggaaatac ccagtatcgt aaagagctga tataacgaag ataaacttcc gcgtatagcg 2985781 ggcggtgccg cttctgtaat atacgtaaca gagagcgatg agcccatccc gattcccagc 2985841 cccccgataa tccttgcaat gattaaggtg gacacgtctt gagaaagcgc tgaaacgatt 2985901 gctgatatcg caaataacaa agcggctgtc attaaaattt ttctccggcc gaatctgtca 2985961 cttaaaaatc cggatatccc gacgcccaca actcctccaa tcataatgct tgaaatgaca 2986021 agtccctcca taaacggact caggctgtat aaatctttca gaaaaccgat ggcgccagaa 2986081 atcactgccg tgtcatagcc atacaataag ccgccaagcc ccgccgcaca tgagatcaaa 2986141 atgacaaatc ccattgaatg gcttcttgtt acaggaacat ttggttctaa ttgagttgga 2986201 gtattcttca tttccctgcc ctcccgaatg ttgagtaaag cgttttcatt taaaccttca 2986261 attgtacgta cttatattaa aatttaacga aaattacatt taattagtac gtacaaatat 2986321 agaataatct tgtttgcatt ttctgtcaat gttttcttac aaagaacgct gtgatatact 2986381 gaaatttgtc cgtatacatt ttggaggaat ggatatgtta ccaaaatacg cgcaagtaaa 2986441 agaagaaatc agttcttgga ttaatcaagg caaaatactg cccgatcaaa aaatccctac 2986501 cgaaaacgaa ttaatgcagc aattcggcgt cagccggcat accatccgca aagcgatcgg 2986561 agacctcgta tcacaaggtc tgctgtacag cgtgcaaggc ggaggcacct ttgtcgcttc 2986621 acgctctgct aagtcagcgc tgcattccaa taaaacgatc ggtgttttga caacttacat 2986681 atcagactat attttcccga gcatcatcag aggaatcgag tcctatttaa gcgagcaggg 2986741 gtattctatg cttttgacaa gcacaaacaa caacccggac aatgaaagaa gaggcttaga 2986801 aaacctgctg tcccagcata ttgacggact catcgtagaa ccgacaaaaa gcgcccttca 2986861 aaccccaaac atcggctatt atctgaactt ggagaaaaac ggcattcctt ttgcgatgat 2986921 taacgcgtca tatgccgagc ttgccgcgcc aagttttacc ttggatgatg tgaaaggcgg 2986981 gatgatggcg gcggagcatt tgctttctct cggccacacg catatgatgg gtatttttaa 2987041 agctgatgac acacaaggcg tgaaacggat gaacggattt atacaggcgc accgggagcg 2987101 tgagttgttt ccttctccgg atatgatcgt gacatttaca acggaagaaa aagaatcaaa 2987161 acttctggag aaagtaaaag ccacactgga gaaaaacagc aagcacatgc cgacagccat 2987221 tctttgttat aacgatgaaa ttgcgctgaa ggtgattgat atgctgaggg agatggatct 2987281 taaagtgccg gaggatatgt ctattgtcgg gtacgatgat tcacatttcg cccaaatctc 2987341 agaagtgaaa ctaacctctg tcaaacatcc gaaatcagtg cttggaaaag cagccgccaa 2987401 atatgtcatt gactgcttag agcataaaaa gccgaagcaa gaggatgtca tatttgagcc 2987461 tgagttgatc attcgccagt ccgcacgaaa actgaatgaa taaaaaaagc aatgtatggg 2987521 tctccccgct acattgcttt ttttatagct gttatctgtt tttccaaacg tcagcgatga 2987581 tttcaaacga acgcattctg tctgcgtgtt caaaggtttc tgagttaacc ataatttcgt 2987641 cagcctgtgt cgttttgacg aaatcttcaa gcttcgcctt cacttcttcc ggacctccga 2987701 caatcgtgga gctcagctgc tcattgacca tcgctttttc atacgggctc cagatttggt 2987761 ccatatcctc aacaggcggt ttaagctggt taggcgtacc gcggacaaga tcaagaaacc 2987821 tttgataatg ggaagtcgca aggtgctgcg ctttctcgtt tgtatctgcc gcgataatgg 2987881 tgacaccgac catcgcatac ggttcgtcga gcacgtctga cggcgtgaag gaattgcggt 2987941 acagctccaa agcgggaacc gtattcgccg gtgagaaatg ggccgcgaac gcaaacggaa 2988001 gaccaagttc gccagccaga cgggcgctga agccgcttga gcccagcagc caaatcggca 2988061 catctatgcc ctctccggga atggcgcgaa cttgattgcg cacatttcct gacggtttaa 2988121 aataattgcg cagttcctct aattgttctg gaaaatcctc cccgctgttg atgtttctgc 2988181 ggagcgctct ggctgtcaat tggtctgttc ccggcgcacg tccaagcccc agatcaatcc 2988241 gcccgggata cagtgtttcc agtgtgccga attgttcagc aatgactaat gaagagtggt 2988301 tggggagcat aatgccgccg gaaccgacgc ggattttctt cgtgcctccg gcaatatggc 2988361 caatcaaaac tgcggtggca gagcttgcaa caccttctat attatgatgt tcagcaagcc 2988421 agtaacggtg atagccccat tcctctgccc ggcgcgccaa gtccatgctg tttcggaatg 2988481 attctgcaat cgttcctccc tgaacaaccg gagataaatt caagacagaa agcaaggtat 2988541 ctttgcgttg gttgttagac atattgttct cctttgcaaa tgtgttatca gtaaacagcc 2988601 caaagctgtc aggtcatgat tgaaagaact tctatcacac cataacacaa ctgcattcag 2988661 gaataaaaga atttgattcg atgaaattcg aacaatataa aacgaacggt ttggaacatt 2988721 attctgctcc aaacaactcc ttagccatct caataaagag cttagccgcc agagaagcct 2988781 cctttagcga cggaacagca agctgcacat cacggtatac ctgcgggtcc aattccctgg 2988841 tcaccacatg ctctggcagc ggcatccccg acatggacat ttctgataaa atggccaggc 2988901 ccaggccttc tctgatcata ctgatcgagg tgttgatgtt atagaccgtg aaagctgggt 2988961 gcagcgtagc acccgcctgc ctgaacatat cgataaatgg tgattcatag ccgccgtcac 2989021 agacgatcat cggttcatgg tcaagatctt tcagcgtaat ggctgaatga ctggcaagcg 2989081 ggtgatcgtc cctgagcacg acagccattt tgtctttttt caaatgaatg tactccatct 2989141 cctctgttgg atacagaaga atcccaacat ctatcatccg cgtatgaagc cactccttga 2989201 cttcatttac agttccctcg tgcagcacga gctcaagttt cggatatttt tgtttaaatt 2989261 cactgatcag cttcggcata aaataagccg aggcagttga gaatgtgccg atatggatcg 2989321 ttcccagttc aagccctttt tccgctgctg ctacctgctc aactttttca atgcctttta 2989381 agacttctct gatgtgtact aagatctgtt ttcccgtatc cgtcagcatc aggccattgc 2989441 ggcggtcacg aatgatcagc tttacatcaa gctcagcttc gatcgcagaa atcgcatggc 2989501 tgacagccgg ctgtgtcatg ttcagcgcct gacccgcttt tgtaaagctt cccgtttcag 2989561 ctattttcac aaaaaccttt aattgagtaa tggtcataac aatttactta tgctccttat 2989621 aaaaaagatt cattttattt atcttatgtt ctaccgtatc atatgatgga aaagttctac 2989681 aaggagtgaa tgaacaatga agcagctccc aaaaacgcgg acagctctcc tgctcgcatt 2989741 tctcgtcatc atgtggggcg tcaattggcc gctgtccaaa gccgcgctcg cctattctcc 2989801 gccattattg ttcgcgggca tccgaacgct gatcggcggg cttttattag tcatagtcgc 2989861 actgccgcgt attcataaat tacgcttaaa agaaacgtgg ccgatttatc ttgtttctgc 2989921 tcttttaaat attacattat tctacggcct gcaaacgatc gggctgaatt atcttccggc 2989981 cggcctgttt tctgcaatcg tcttcttcca gcctgttctg atgggtgtat tttcttggct 2990041 gtggctcggc gaatccatgt ttgtaatgaa agtgattggc ctcatcctcg gttttgcggg 2990101 agtagccgtc attagtgctg cgggctttgg cgggcatatt tctgtcattg gggttctgct 2990161 ggctctcggc tccgcagtca gctgggcgct cgggacagta tatatgaaaa aaacaggcag 2990221 ccgcgtcgat tccatctgga tggtcgctct gcagctgacg atcggaagcg tgtttctgct 2990281 tatctccggc ttttggacag aaagcttttc ggcgatccaa tggacagctc cgtttattac 2990341 gagcctgctg ttcatctccg tattcgttat cgcactcggc tggcttgtct tttttacgct 2990401 tgtcggttca ggagaagcaa gcaaggtcgc atcttatact tttttgattc cgctcatatc 2990461 aatcgtggcc agctccattt tcctgcatga accgctcacc cttagcctct tggcagggct 2990521 gctgctgatt gtcacgagca tctgtctcgt gaatacaaaa tcaaaagcgc agaaagctgc 2990581 ggcgattggt ataaacgaga aagctgcaca ataataaaaa ccctcttgcc ggatgcggca 2990641 agagggtttc ttatttactg atgcttgcgt cctttgacca aatatgcaac tgtaatcaaa 2990701 aggtagatcg ccgcagtaat gccggtaatg acaattgatg ttgtcatgat gaccccgatc 2990761 agaatggcga gtaatgccac aatcgcaaac catgtcgtgt acgggaacca ttttacataa 2990821 taggccggtg tttccgtttg ctgttttctc gattttaaat gagcgaatcc gatgatcagc 2990881 caaatgaata aaacggtata tcccaatgat cccattaaat aattaaatgt ttggcttcct 2990941 gcgaacagag aaatcaatac gccaatatag agagaagaag tgcacatcag aatcgcaaac 2991001 atcggtacgt ttttcgatga aagcttcgag aagacctttg gaagccttcc gtcacttgcc 2991061 tgtgtataca aaatgcgtga tgatccgtat aaacctgaat tcatagaaga aatgatcgcc 2991121 agcaggatga ctgcattcat gatatgatcc gcgcccggaa tgcctaccat tttaaagacc 2991181 atcacgaaag gactttccgg aacggaattg acttggttcc atggaatcag gctgacgatg 2991241 atgaaaaacg gcagcaggta aaacgcgaca atccgtgtca gtgtgctgcg gacagctttc 2991301 gggacaacct tttccggatt ttttgtctct gcaagcgtta caccgataat ttctgtaccg 2991361 ccgtaagagt agatgacgac aagcatcgcc gtgatcagcc ctgtgccgcc gtgcgggaaa 2991421 aatccgccgt ggtctgtcag gttggaaaat ccggatgctg tatgatcacc gaatgataca 2991481 aataagagca gcaatcccag aataataaag ataataataa cggtaatctt gatcattgcc 2991541 agccaatatt cagtttcggc gaagatttta acagaaagca agtttacaat cgtgacgata 2991601 agagaaattc ctaatgccaa cacccagatc gggcagcccg gcagccaata ttgaatgaaa 2991661 atcgcagcta caacagcttc agccgcaatg ttaagcaccc acattttcca gtagatccag 2991721 tccaaaaagt aagcagcgta atttcccaat acctgctgga caagatcacg gaaggttctg 2991781 gcgttacggt ttcgaacagc catttccgcc agcccctgca taataaacag caaaataatc 2991841 ccgccgagca ggtatgcgat aatgacagat ggccctgcca catcgatcgc tgagctgctc 2991901 cccttaaata aacctgcgcc gattgctccg cccagcgcca tcatcataat atggcgggac 2991961 gtcatcgtgc gttttaacgt ttgattgtcg tttttcatcc tcttctacct ctccttctcg 2992021 ttttcaaaaa caaaaaagcc cgccgtctcc tacctaatct aatagataaa gagacgacga 2992081 gccttcggct gaccgcggta ccactcttgt tgattcttca tgaagaatcc tgcttttgac 2992141 ctgtaacgaa ggttagccgt taaaacatag ggaatattca atctattccg ttccgtctta 2992201 ccactcccgg gcgagttcaa agaagaatca ggctgcgtcg caccaccccg cagctctctg 2992261 ttctgatcac tttcttttac tgctcccaat ctatgtgttt tagttttctg aaaaactcaa 2992321 attttatgat ctgaatatat taacataata tacgtgcttc tcttttaact gtcaataact 2992381 tcagagaaaa aagaaactgt tattttgtcc cttttcgaat ggctttccaa aaggattctg 2992441 actcgtttcc taatgcgtaa actgaaacac ctgctatttt atattgcttt gccagatggc 2992501 ttttcgtttg aacggttttt tcgttttcat accacacgac atgtttatgc ttctttttgt 2992561 caacataaga aaacgtcatc gagcctgatt ttttgttgaa tgccggcttt gctttttgtt 2992621 ttttgatgag ggatttgagc tcattccatt cccttattgt gctggtactt ccgtctttta 2992681 catcccagtc atagccgtac gcagggattc ccatgatgac tttattggct ttgatctttt 2992741 tgactgaaaa ctgcagagag cttttgatcc agtttgtgct tgccactgac cccggctcac 2992801 cccaaatgcc gtgttcatcg taggtcatga cttgtacgaa gtcggcatat ttgccgattt 2992861 tcgcataatc atacggccag ctccagtcat catttttatc atcggcgctt ttggccggaa 2992921 cggataccat tgttttaata tgtttcttat tcaaagcctg tgagacatat tgaatgaagt 2992981 tcgagtatgc agcgcggtct tctggattta ctgcttcaaa atcgatattg attccgtaat 2993041 atgagtgctt tttggccagt gtaattaact gatctgtgaa tcgttttttc gctgttttat 2993101 tgctcatgac ccgactcgct aaatctccgt caaaatcata aatggcatca ttatagtttg 2993161 aaatgacagc ccatgtcttg atttttttct ttttcgcata tgtcagctgc ttagttgggg 2993221 catcgccaat gatttgtccg tttttttcaa acgcaaatgt atcggttgcg atggcattca 2993281 tgtatgtatg atatttcgta agagaattgt atgaagccgt atccccagtc gtgtagccta 2993341 ctgtcatacc ggctgccttc gcttctcctt ttgtatacat aaacagaaca atcgcaatcg 2993401 ccagtgaaac cgctatgatc agccattttt tcatcgcatt tcctcctgta tcaagtcata 2993461 ctcttctcat cggccaaaaa attggaagtt gaagtttttt caagcaaaaa gcccggcata 2993521 tgcctgccgg gcttcctgag ttcagcggtc agagacgaga atatatgctg cctttactgg 2993581 tccatgcacc cccacaacta aatccatttc aatgtcggct gagttactcg gtccggtaat 2993641 gtagttgata catgaaggaa cagtgacacc gttcgcaatg ttttggcgga tgatatcact 2993701 ggcttgtgtc attctcggta caatgcttga tttcggcacg atcgcaatat aagtcgttgg 2993761 caaaaggctg acagagcggc cgatgtcttt tgaggagaag aggacaaccg tccccgactc 2993821 agccaatgta atttcgctga atgtaatccc tacattggct tgctccgctt ttttaatatt 2993881 ttcctcgcct ttgtcagcat cccactccca gaccggcgtt ccttcactcg gccagtcctt 2993941 ggtgagcagg cttttcagtc cgtattcttc aaagcggggg tccttcggaa tgatgacagg 2994001 gcctccagaa aagcggctga cttgctcgcg cagggcatcg taaaggccgg ttgaatccgt 2994061 ttcaatcagc tctgtatgga ttttgacaca atggtttttg agcactgtga ctaagtcatc 2994121 cgctgaataa ccttcaagtg ttttatattg cggctgatgc gcccattcag ggactgccac 2994181 gcctcctgtt cttcgttcac ggcccaggct ggatgcgatt cggtttaaaa agctctcttg 2994241 attctgaatg gttcccttcg tcatcactgc tcctccttcg tgcgttcact tgtttctctg 2994301 tccgcaaacc agtctctgaa tctcgattta tgcggtgccg ggaagtcgcg aatctgggtc 2994361 caatttttaa gcgggccggg ccctttcgaa attttttcgt cctctgtaaa aggcgtcatg 2994421 gcggccggcg cccattttga gcccattttg taaagcgata aggaggatgc gccaagtccg 2994481 aatgctttca ttgcaagctt ttcactgatc ggcgccctgc cttctttttc gacgatattc 2994541 tgacgatgct tgagtagcag ctcatgaagc gggattttga ccgggcaggc ttctgaacaa 2994601 gcagcgcaca gtgaagatgc gtacggcagc tccttataat cgtcataacc gccgagcaac 2994661 ggtgataaaa cagctccgat cggccccgag tagattgagc cgtatgaatg tccgccgaca 2994721 tggcggtaca caggacagac attgatacag gcggcacagc ggatacattg cagcacagac 2994781 tggaattccg ttccaaggat attggatcgt ccattatcaa cgatgacaag atggaattct 2994841 tccggaccgt ccacttcacc ttccagcttc ggacccgtca aagctgtaat atagcttgtc 2994901 agccgctgtc cgacagcact tctagtcagc atgctgacta gcacttcaaa ttcagaaaat 2994961 gacgggacaa tccgctccat tcccatgacg gtaatttgtg ttttcggcaa ggtgctcaca 2995021 agccgtccat ttccttcatt ggtcacaagg ctgacggaac ccgtgtcagc gatggcgaag 2995081 ttacagccgg taatgccgat atccgcttcc agaaactttt tccggagaat ggcgcgcgca 2995141 tgcatcacca gctcttccgg tttttctgta tgttgatagt ccagtctttc tttaaacaca 2995201 tcgcgtatct gctctttatt tttatgaaga gcgggcgcta cgatatgtga cggcggatcg 2995261 tgatcatcaa tctgcaaaat atactcgccg agatcggttt ctacgacttc acagccttcc 2995321 ttctccagca cctcattcag attgatttcc tctgtgacca ttgatttaga tttcacaatt 2995381 ttcttcccgt tcttcttttg aatgacatcc cgaatatagg aagacgcctc ttccgctgtt 2995441 ttcgcgaaat agacatgtcc gcctcttttc gccacatttt cggcaagctg tccgagatag 2995501 aaatcaaggt tttcaaggac atgctgcctg atttcctctg ataatgagcg ccactcctcc 2995561 cagtttccca gttcttctgc tgcctctagg cgccgcgtcc gcagacgctc ctgtgcacct 2995621 gaaacagcgc ctctcataaa ttcattatca atcccctgtg atacccgctc tttaaaagcg 2995681 tcagtaccga ttttcatcgc catgatcctt tccccctctg aatccagttt tatctgctgt 2995741 tgagcacttc ggcgatgtgc atcactttga cattcttatc ttttcggcca agccgtcccc 2995801 cgatattcat caaacagccg cagtcagcac cgatcagcac ctctgctccc gtttcctcca 2995861 cacattcgac tttttcatcg accatctgct cagaaatctg cgccatcttg actgagaacg 2995921 ttcctccgaa tccgcagcag ttatgtttgc ccggaagctc tgtaaactgc aggcccttca 2995981 catggctcaa cagcttcatc ggctccttcc gaacacccag cagcctagtc atatggcacg 2996041 acgtatgtaa ggtcgctttt gtatgaaggg tcgcgccgac atcctctacc ccaaggacgt 2996101 tcacaataaa atctgtcagt tcatacgttt tatccgccag ctttttcgct ttatcggccc 2996161 atttcggatc atcctgaaac aggtgcggat actcccggaa catcgttgtg caggaacccg 2996221 aaggactgac aacatattcg gaatcctgaa acgtttcgat catccgtttc attgcttttt 2996281 tggcgtcatg tacatagccg ctgttgtaag ccggctgtcc gcagcaaatc tgcccttctg 2996341 gaaaatcaac ctcgcaccca agccgctcca gcagctcaac cgttgctttt ccgacatttg 2996401 tttgaaacat atcaacaaga caagtgacaa aaagtgagac tttcatgatg aacccctctc 2996461 tcatccccaa tatatgatca ggtcatctga tgacctgagt taaaataact atatgaatat 2996521 cgtacactat tctgacaatg gaaggaaaga gttttctagg gatattttca tttgtggcat 2996581 atcaaaaaca ctcccgatct cccaggagtg cagtatatgg ttagatccag cccttttcct 2996641 cagcgatgct ggcggcttct gtccgatttt tcgcattaag cttttggatg atttctgaga 2996701 tatagtttcg aactgtgcct tgagataaat agagctccag cgtaatgtct tttgttgtct 2996761 tgcctaaagc cgcaagcctc agaatttctt gctctctaac ggttagcgga ttttcgtctc 2996821 gcatcatatt aaacgtcagc tcagggctga agacacgttt tccctttaca cattttcgaa 2996881 tggcatcggc cagatcgtca atttcaccgt ctttcagcag atagccatgt gcaccggcct 2996941 ttacggcgcg ttcaaaatat ccggggcggg caaaggtggt taaaataatg accttgctga 2997001 cgcagccttt tttcattaat tcctctgcca cattcagccc gcttcgaacc ggcatttcaa 2997061 tgtccataat gcatacatcc ggctccagct tcaaaatagc atgtagcgcc tcttccccgt 2997121 ttaatgcttg tccgatgact gtcatatcct cttctaaatc aagcaaagat cccaaagcgc 2997181 ctaaaagcat tcgctggtcc tcagcaataa acagacgaat cattcttttc gtcctccaat 2997241 cattctgctt ttttaataag cggaatcgtc agtgccacaa ccgttccgtt atggtctgaa 2997301 accgttaatc ccccttcaat gagcatgagc cgttcttcca ttccccacag gccattccca 2997361 aacattttct ccttcggcgc tccctttccg tcatcccgta ttacgatcct cattttgtca 2997421 gcaaattgag aaatggtgat ggcacagtgg gttgctttgc tgtgcttgat aatgttagtc 2997481 acggcttccc gcatacacat actgataata ttttgagtga cgggagatat cactgaaaag 2997541 tcgtcggctc cttcgtattg aaaggtaatg ttccccgctc ttaatatgtg ctgaatgttt 2997601 acgagctcct ctgttatcgt gaccgttctc atatcagaaa ccagctctcg aacttgcttg 2997661 agtgcggagc gtgaactggt ttccatttct tttgcctcaa gcttggtccg ttctggatca 2997721 gatgcagcca gccgctgaat gagctggctt tttaatgtaa gcagcgacag ggtgtggcca 2997781 agagtatcgt gaagatcacg ggcgattcga acacgttcct cccttttaga gagttctttt 2997841 atctgttcgt tggcttgtgc aagcttagct tcaagctcaa tcctccgaaa catagaacga 2997901 attccgaatg gagaaatgag cataatgacg agaaacggga gaacagaaaa aagctcccga 2997961 agcgagaccg aattcgcgat aaattggtat aggcatggaa aaagcagtat aaagattaaa 2998021 gcgcagaacg cacggttaaa attcgttttc tctttgtaat aaccaacaaa gtttgccgga 2998081 aaaaaaccta agtatatata ggtgatattg taaaacacac tatacatcaa aataaccgcc 2998141 atttgcacga taagccaata tgtaaacgaa gctttgccca cgctgcagaa taactggcga 2998201 tatgccgcta caaaaaggag cagcatacca tatccgatcc cctgtttgac ccctgattct 2998261 tttaataaag agaggaacgg cataatcgta tacaccagaa agatataagg gaaaaacccg 2998321 aattccttcg ggaaaataga tattgccttt ttcatgtatt acaccgcttc ttgttttctt 2998381 cttatatatt tagatagtag catgaagagc atcatataag cgattaatat cagaatattt 2998441 ttccaagtcg gactcccacc ccggacaagt tcccacgctc cgctcccgaa atgataagac 2998501 ggaagccact ggccaatgct ctgcatcatg tcaggcatga cctcaaacgg catccacatc 2998561 cctccgccta aagccagcag catataaagc acattactga ttccggccgc tgtttctact 2998621 tttctcatga ggccgattag tgtgcctaat gctaaaaaag gcaatgcgcc aaacaaaatc 2998681 cacagtccgc tcatcatcca ttcaaacggt gacaaggcaa tatcattgat gattgcgccg 2998741 aacagaaata tgacggtaat tgataaaacg tgaatgacac tttggccgat catctgagct 2998801 gataaataga tatgatccgg aagaggcgta aggcggataa aggcggccca gccttgtgac 2998861 cgttcttgta ccattcggat gccaagcgtc atgatagagg aacccatcac gctgaagact 2998921 gtcatcgaca tcaggtaatg ggcttcccat gcacgttgat cagggacgtt ggtattcact 2998981 acatttgtaa agaaataata aaaggcaatc ggcatgatca gagaccaaag cacaaagtac 2999041 ttgttcctaa gcaccctttt catttcagcg atgctttgct tttgcagcac gttcactcac 2999101 atcgcctccc tgttgccgtc agccagctgg cgaaatgcct catcgagcgt tgcttgctca 2999161 attcgaatat cccgtgcatg tatgttttct tgaaagatca gcgccaacac tttgtctgta 2999221 tttgatgtct ggatgatggt tctctcatgc tcgtggatca ctctctcgac ttccgggtga 2999281 caagacagcc tttccaatga ttcacttgaa tgaagcgtaa aggaaacaga ctgtttttga 2999341 attcttgagc ggatttgcat tggtgagccg tctgcaacaa gctgtccttc agtaaaaaat 2999401 aggattcgct gtgcggcatc atctgcttcc tgtaaataat gagttgaaaa aataatcgtt 2999461 tttccttggt ccgacagtcc gtgaatggtc tgccagaatc ggtgtcttga tgaagtgtcc 2999521 atgccgactg tcggttcatc aagtataagc agctccgggt tcccggcaag agccaaagca 2999581 aagctcaaac ggcgtttttg tccgccggat aatttttctg ctcttgtttt caaatcttct 2999641 ttggtgagtg ctgttaacga aacgagttct ttcatggaca atggattcgg ataatagctc 2999701 cggaagagtt caaggatttc atccacctta aggcccggca tgacacttac ttcctgaagc 2999761 attacaccta ttttttcacg aacctgttga tcatcgggaa cccggttaaa tagtttgatt 2999821 tctccctcac tcggtttcag caatcctaat atcatcgaga cgacggtcgt cttccctgcc 2999881 ccatttggcc cgagaatggc tgcaatttct cctttttcaa tactgaagct gatgttgttt 2999941 acagcggttt ttcgctggaa atgttttgtc acgttgctta ctgttactgc ttctttcatc 3000001 acatgagcac ctcctgatcg tttacattga ttgtaaaatg acggagaaga cgatgttagt 3000061 atggggtgtc atgatgatgg agtgacaaat gtcatttttt tctcaccccg gtgtctaggc 3000121 aatcctcctc ctgcatcttc caattcatcc atcttttcta tctcccatgt cctctttctt 3000181 ttaaactgct gtgacattca tagaaagata cactcttcaa accatccgag tgttatgata 3000241 gaaatattga actttatatt actttccggc tgaaaggagc caatcatgaa cgaagcgatt 3000301 ttgtctagaa atcatgtgaa ggtgaaaggc agcggcaaag catctatcat gttcgcacct 3000361 ggttttggat gcgatcaaag cgtgtggaat gccgtggcac ctgcctttga agaagatcat 3000421 cgggtgattt tatttgatta cgtcggttcg ggacattcag atttgcgcgc atatgacctg 3000481 aatcgttacc agacacttga cggctatgcc caggatgttc ttgatgtttg tgaagcttta 3000541 gatctgaagg aaaccgtgtt tgtgggtcac tccgtcgggg ccttgattgg gatgcttgca 3000601 tccatccgcc gcccggagct tttttcccat ctggtgatgg tggggccttc tccttgctat 3000661 ttgaatgatc cgcctgagta ttacggagga tttgaagagg agcagctcct tggcttgctg 3000721 gagatgatgg agaaaaatta tatcggctgg gcgactgtat ttgcggcaac cgttctgaat 3000781 cagccagatc ggcctgaaat taaggaagag cttgaaagcc gtttttgttc tactgatcct 3000841 gtcattgccc gccaattcgc gaaagcggcg tttttttctg atcaccgaga ggatctttcg 3000901 aaggtaacgg ttccctctct tattctccaa tgtgcagatg atatcatcgc acctgcaaca 3000961 gtaggtaagt atatgcatca gcatctgcct tatagcagtc tgaaacaaat ggaggctcgc 3001021 ggacattgcc ctcatatgag ccatccagat gagacgatac agctgatcgg cgattattta 3001081 aaagcacacg tgtgatatag gaacgaaagg gatagaggtg accctcttag atggacaaac 3001141 aattgaatga tgcaccatgc ggtttcctcg ctttgtcaga agaggggtcg atcatagctg 3001201 ccaaccgcac ccttatcaag attctggatt atgaaccgga gcaggttatc ggccagcaca 3001261 tgaatatgat gttgaccatt cccgcgcagc ttttctgcca gctttatttt tttccgcttt 3001321 tgaaattgga gcatcacatc gaagaaatat acatttccct gaaagcaaga gatggagaag 3001381 aaattcccgt ccttatcaat gctattgcga gacacgatag cggggcttct gtctttgatt 3001441 gtgttctgat tccaatgcga aagcgaaatg aatatgaaaa tgagctgctg atagccagaa 3001501 atgaggctca ggaagctttg cttgccaaac agaaagccaa tgcggagtta gaaattgcct 3001561 tggaaacgct gaaagcaaaa caagaagaac ttcttgagat caataaacaa aatcaacaat 3001621 ttaaattaaa caccaaaaga gagcttgaac tcgccagaaa gatccagaaa aactcgttga 3001681 ctgaaccgat tgtaaacgat caggttcaga ttgactctta ttacaacgca tcgagtgaat 3001741 tgtcaggtga tctttacgga tattatcaaa tcgatgaaca ccgttacggc attattatcc 3001801 ttgatgtgat ggggcacgga atttcatctg cattgattac gatgtctctt catcctttgt 3001861 tccagcgcca gatcacgcaa ggtctcagcc ccgttaaagt tatgaaggaa ttggaccggc 3001921 accttcacag cttgtttcaa aatgatgagg aagcaagaca ttattgcact gctatttatc 3001981 tcgagattga tatagcacgg caaagaattg attatgtcaa cgcagggcat ccgccggcac 3002041 tttggcagga cgatagcgga actcaacatc tgcttcacgc gacctcgcct ccgatcggga 3002101 tgtttgaaga cttagagttt cagtcaagca gcctttcata cacggaggac ggaagattgc 3002161 ttctgtatac ggatggcgtg atggatccta cggcttcatg ttatttattt gatttactaa 3002221 aggatcatcc tgattcgcca atcgctgacc tgaaggagaa aatccttaca tcactgcagc 3002281 atcaaaagga agctcatcat aagagtgatg acgaatgttt tatattagtt gatgtaaaat 3002341 aaaatgatcc atgagacata acaatgattt gttacatctc atggattttt ttgtttcagc 3002401 gtttctttgg aatatgtcct gactccgcat attgaaacac ctgcaaggaa ggcagcgggt 3002461 gtccattaaa atcaaataaa gcttgattat ctacagcact tcccccatac cacttcccgg 3002521 cgtcttcagg gtcgtattca gcagcatagc tggacgccca ccctgacccg tatgtttccc 3002581 ataacacttt gtttttctct atctgtgtct tcggcccgac tggaatccac gccggctccc 3002641 agtagaaaac accaagtcct gctttgcccg tattcgccac tgcctccatt acatctctta 3002701 ctgcagttgc ctggccttga acagaaattg gatatggcaa cgtctgcccg ctttttggtg 3002761 ctgtatttcc atgcccatcg ccatcctcag cggtataggt gtacgatgtc tccgccacca 3002821 tgactttttt gccgtacgta ttggcaacag ccttcagcac ggaggtcaaa ttttgtaatg 3002881 tgccatgcca gaaaggataa taggagctag caaacacatc ataatccact ttgtttttgc 3002941 tgagtgtttc tgcaataaat gaataccttc cagccgtttc aggattggta aaatgcaggg 3003001 cgaccaaaat atttgaattt gtctccctga ccgctcggct tccttcatta aataattggc 3003061 acatcttcgt ccaatcagtc tcaccggcaa atcctcctgt tgtttcattt ccgacctgaa 3003121 ccatgccgat gtcaacgcct tccttgatca tcttttgcag gctttgtttc gtatactcat 3003181 agagctttgc tttttttgct tcaaagctga gattcgccca ggctttgggc accttttgtt 3003241 tcgctggatc ggcccagaaa tcagagtagt gaaagtcggc cagcaccttc attccgttcg 3003301 ctgtcgctct ttttccgatt tcgatggctt tttgaacatc attgtttccc ccgccatacc 3003361 cgttgccatt tgaatcatac gggtgattcc agatgcggac gcgaacatag ttgaccccag 3003421 cctgttttaa agttgtaaag atatcctggc gttttccgtt tgtattgtaa aaggtgacac 3003481 cgctgttttc caaagcaata acgctggata catctgcccc tttgataaaa tccttgttca 3003541 tcccctctac ttttttaaca aaaagatcct ctgcccgaag ctctgacacg tgcttctcct 3003601 tctcaatggc agcggcatat cctgttgaac tacatgcact ccacacgatg gcagccgcaa 3003661 agaacatttt cactttgctt ttcatgattt catcccccca agacttagca agcgttttca 3003721 ttctatagaa aaaagaatcc gcccatatcg agcggagcat cagcctaatg tgtgtttacg 3003781 acaattctca cttcatactt ttccatcgtc aggtcgcctg acaatatgtc tcctgtcatt 3003841 atgtccttca cactctgatc aaacgtgacc agctgttttt cttccgtgaa attcatgaca 3003901 aaaatataat cattgtcctg atcctgcctc gcttgtacgg agacgccttt tccgtgccga 3003961 accggaaaaa ctggagagag agacaggtct gtgatcagac cctcatagaa atcacgctga 3004021 aattgatcct ccaaacgcgc gccgataaaa tacgccttgc cctgctgata ctcatggctt 3004081 gtgaccgctg gcgtgcgcgc ataaaaatct tcttgataca ccgcttccac tgaagctgtc 3004141 tttacatcaa tcacggttgc ataatccttc atttcatata tttggctgcg gtagctgaca 3004201 gcgtttcgat ccttcggata cagggtgtcc gtttcaagag gctcaactcc aaatatagct 3004261 tgaagatccg gatgccatcc gcctgtgtat gttaagtcat gctcattcac aaccccgctg 3004321 atatacgtca tgactaaggt gccgccgtca gccgtaaacg cttttaaacg ggaaacggtg 3004381 tcctcgctga ttaaatacag catcgggacg atcagcagtt tatatggtga aaagtcttgt 3004441 tctttcgtga tgacgtcgac agggatatcg tgttcccaga atgtgcggta atgctgctga 3004501 agcgtttgcg gataacgttt tgtcgccttc gcaaacccct gagcatcctc gagcgcccaa 3004561 tgattttccc agtcatataa aatcgcggtt tgagccggcc tcttcgttcc gacaacttcg 3004621 gacagccgtt ccaatgtctc gcctaccttg gccacttctt gaaagacgcg gttcttcggg 3004681 ctattgtcat gatccacaac cgctccgtgt aatttttctg atgacccccg tgatttgcgg 3004741 tattggaaat agagaacgct gtccgagccg tgggcaatca tttgcatgga tgacagcaga 3004801 ttcatgcccg ggcgctttgc cttgttgacg ttatgccaat tgaccgcgct tggcgtacac 3004861 tccattaata agaagggctg ctgcttcaag cttcggtaca gatcattgat aaagccgacc 3004921 ttcatcgcca aatcagctgt gctttcccag tcattgtgcc agacaggata agcgtcccag 3004981 ctgatggcat cgacatgctt tgcaaatttg ctgtagtcga ggccctgata cgggatcaaa 3005041 tccggtgtgt cagccataaa attcgttgtg atagggatat caggcgtcaa ttctttcagc 3005101 ggaatgattt cattttcata aaacgaaatc gtttgatcgg tgacgaaccg gcgccaatct 3005161 aaattcaggc catgcaagcc attttcaccg atcggcgaag ggctttcaat ttgtgaccag 3005221 tcattgaacg tatggctcca aaaaggggtc caccacgcat ggttcaatgt cttgaggctg 3005281 ttgtcatatt tcgatttcag ccactcccgg aaagcatgct ggcataaatc acagtggcaa 3005341 tctcccccgt attcgtttga aatgtgccac attaacagcg ccgggtgatg tccgtatcgt 3005401 tctgctaata agcggttgat gtgccgtgtt ttttctcggt agactttaga tgtgaggcag 3005461 tggttgtgcc ttccgccgtg cagctgtttg acgcgggagg cattgacgcg caaaacttcc 3005521 ggataggttt gcgacagcca ggccggacgg gctccgctcg gcgttgctaa tatgacccgg 3005581 ccgcctatac tgtgaatccg ctcaaaaata tcatccagcc attcaaattg atatacgccc 3005641 tcctccggct caagtgcgct ccatgcaaaa atgccgacag aaaacgtatt cgtatgagaa 3005701 agcttcatca gtttgatatc gtcagctaaa atatcgggcc gatccagcca ctgatcgggg 3005761 ttgtagtctc ccccatggag cataaatttt gcttttgtta cgtgcgtttt ttcaagcttt 3005821 gacatcacat tctcctcctt gttctcttag cccttcgttc cgcctgcggt taatccggac 3005881 acaaaattct tttgcagcat aataaagatg acggcaaccg gtatgctgat aagcagggct 3005941 ccggccgcaa atgtcgtata gctggccccc atgacatcat tcactaaatt gaatagaccg 3006001 acgggcaatg tatatgattc aggcgttctc aatatggttg aggacagcac aaaatctccg 3006061 agcggaccgg taaagccgtt catggccacg actgccgcca tcggttttga taatggcaga 3006121 atgatctgga agaagattct ggtgctgctg gctccgtcaa tcttggcgct ttcgtctaaa 3006181 tccatcggaa tggaatccat gtaccctttc atcaaatacg tattcatcgg gatcaggccg 3006241 ccgatataaa gcaagattag cagccagtgg ctattgatca ttcccaagat ttgcgccagc 3006301 acaaacaagg caattaaagc tgaaaactga ggaatcatct gcagcaataa aaagagcgtt 3006361 aaagcgtatt tcctcccttt aaaccgaaag cgcgaaaacg cataggccgt aaacgtcaca 3006421 cagagcaaag accctgccat tgtaaacagg ctgatcttca tagagttgac ataccactgc 3006481 acatattgaa ggctttcctt gcccgcaaat aattccttgt aatgatcgaa tgtcggatgc 3006541 ttcggaatga tggatgtact gattaagctg ttgccgggat taaagcttgc gcctgccgtc 3006601 caaaggagag gataaacaat gatgaccgcc ataaaggcta gcaacaagta agagaaaagg 3006661 agacggatat atcttctgac tttcatatct gccagcatac cttatgcctc ctctttaaaa 3006721 gactttgtct gtctgaactg ccacaatgcg atggagataa caaatacaga taataaaatg 3006781 gttaaagccg cagcaagtga atattggctg gactgcattg tcaatttata aatccatgaa 3006841 acgaggatat ctgtcccgcc ggctgttgat ccggttacag ccggacctcc gccattgaat 3006901 agatagataa tattaaagtt attaaagtta aacgtaaact gagtaatgat aatcggagcc 3006961 attgcaatga acaccatcgg aagcgtgatg tatctcagct ttgaaaagac agaagcgcca 3007021 tcaatcgtag ctgcttcata cagatcgtcc gggatggatt gcaatacgcc tgttgagacg 3007081 agaaagatgt acggaaatcc gagccagccc tgcatgagaa tcaatgcaag cctcgaccaa 3007141 ttggcatctg tcatccacgg aagcggatct atcccgaaga aagccaagat gtcgtgattc 3007201 atcgcaccga agctatcatt aaacagtccc gcaaaaatta aaatcgtcac aaaaccggga 3007261 acggcccatg gcaaaatcag aatcgtccga aaaaaacgtt taaaccgaag gtctttctgg 3007321 ttaacaatga tcgcgagaaa aatccccaag gtgacttgca gtgtggatgc agcaagtgtc 3007381 caaaccaccg tccaagccag tacatcaaaa aaagtcgacc tccaaatatc aactgtgaaa 3007441 atatttgcga acgtttgaaa accgacccaa tcaattaatt ttgcaggagg agaatgatac 3007501 aaatcatagt ttgtaaacgc taatgcaaag ctgaataaga taggaaagat cacggcgaaa 3007561 attaaaataa acaaagatgg gccgctgacg acataaggat agccctcaga aatgatatgc 3007621 tggtattgtt cctttaagga acttaatggc ttattttcat cacgctgttt tccgctttgg 3007681 aacgcatcgc gaagatttac ataatacacc gcaaggccaa agcaggtcac gatgacagca 3007741 ataatccctt ccgccagcag aaaaacggaa ttatcccgcg gcacttctgt tcccagtgta 3007801 aagattcccc aaaaccccat attgagcaga tctccaaaga ccgcaaaaaa cgatgcgcct 3007861 aagaaaagaa agacaatacc ttttatccat tgcttgttat aaaattgccc gagtcccgga 3007921 atgatagaaa gcaacaaagc gacttgacga tgctgcaccg ttttcacctc tcttacaata 3007981 caaatctagc tttctcttta ttttccgctg tgctttgcct taatttgtcc tttggccgtt 3008041 tcagctgctt gatccaatgc ttgtttcgga tctgccttcc ctgttgcaac cgtctgtaat 3008101 gctgaatcag ccggcgtcca tatttcattc atttccggaa tatttggtgt tggctctgag 3008161 aaacgggatt gttcagtaac agcccgtgcc gcctcgcttt tcataatagc cgggtcattg 3008221 gctagggatt tcacagcagg aacttctttc gtttcttcat atcgtgtttt agaatttttt 3008281 tcatttgcca ggaaaacggc taattcttgc gccagctctt cattctttga aaatgcactg 3008341 acgttgtagc ttttgacgcc gataaaggag ctcatgtttt tcccattttc cagcttcggc 3008401 agtttcgtaa tgccataatt gattcctgca ttcgaaaagg cttctacatt ccatggacca 3008461 gaaataattg cggcggcttt tccttctgtg aacagcgatt ccaacacgtt aatcccttgt 3008521 tctccaataa tgccagccgg gaacaggcca tctttgtaaa acttctgaat cagcgccgca 3008581 cctttgacag ctccttcatt attgattcca atgtctgacg ggttatagct cccatctttg 3008641 gcctttccaa aaatgtatcc gccatatccg ctcatcacac tttctgcata ataaatttga 3008701 tcgaataggg ctaaaaagcc aaatttgctg ccgtcagcag tctttttgga atagtcgtac 3008761 cactcttcca gcgttttggg caattccttt tctgtgatga gatctttgtt gtaaaaaagc 3008821 acagtcgttt cgaccgcttt tggcagtcca taaagctttt gatctaccat ttgagactga 3008881 atggaagcgt cagtataaag tgattgaacg tcttttttga catgtaattc cttgagtaat 3008941 ccttccgtga cagcggttcc gatttggtcc cctggcattg ttaacacgtc agggcctgtg 3009001 ccggccggtc catccattcg caaatcttca atctgcttgg catacggttt ttcaacgact 3009061 ttgaccttca catcatgctc tttttcaaat gcagccacag cgtctttaat gccgttgctc 3009121 ttttctttat cctcccatac aacaagctct gacccttttg aactcgattt ggcgctgctg 3009181 ctttcctttg ggccgcaagc cgccaaggat aaactgacag ctgcgcagag catgaatacg 3009241 gaacactttt ttgccatttt cattgattgt caccctttcg gtaggaatga aagcgcttta 3009301 aagataatat agcatgcctg agaaaatgtg taaacaaact atttacttca tagagtaaat 3009361 ttttttacct aaataaaaaa tgacttagtg tcctaagtca tccttaattc atactcttcc 3009421 tgacgattaa ttctgcgccc acatataatg tttttaccgt tcttctcttg tcctgcactt 3009481 gttcaagcag taattgaaca gcgtttttac ataattcatg tatatcaata tgaaacgtcg 3009541 tcagaggagg cgagacatac ttcgcgaagc tgatgttgtt gatactcaca atgcttaccc 3009601 tgtttggtat ggcaattcct ttttcgttca gggcttgcag acagcccact gcaatcgggt 3009661 ccgctgcaat cataaaagca gtcggaagct gatcgcctaa tgtgtcgatc gctgctgaca 3009721 tcaggcggta gccgttttct acagagaatc cgcgatgaca gaaaatatag cgctcgtcca 3009781 gcatggcttt ttccctcata taggatctga aggtttgttc acggatgtcc atttcatcct 3009841 gattggtatt cggatttttg tatgtgccgc cgataaaacc gatgctctta tgccccttct 3009901 cagtcaggat gtttaccgtc ttccttgtca tttgtgccaa atcgggcctt accgagtcaa 3009961 aatgatcggg atcaggagtt gaatcgatga acacgccgtt ttcagtgaga tttctgagga 3010021 aagccagctc ttcatctgaa aatgtgccga cggcaataaa cccttccgta tgttcaggaa 3010081 tgctctcgat tccatccgct attttataag tggtcatatc gacattgaat gctttcgcca 3010141 gtttctctac ttctaatctc atcgttttaa aatagacatc ttctaattct tctttatctg 3010201 tcagccaata taaaaacgca atatgtttca ccagcggcct tactgttttt ttgcggtaat 3010261 tgagcttttc cgccgcttca tagattttct cccgtgtctc atcaggaaca gaaaggcttt 3010321 catcgttatt taaaacgcgg gaaacggttg agattgaaaa tcccgcttcc tgcgcgatat 3010381 ctttaattgt cgccattgta tctgcctcca ttattcagct cgcattgttt tagtaaaata 3010441 ttttactttc tttttcacaa atgtcaagtg cacaaagccc tctggctgcc atgtaaaaag 3010501 actgaaccat ttgcggctca gtctcagttg ttcgtatcat tcggaaccgg cggaattgcc 3010561 cgggaaatga gttggttatt gcacattttc ctcgaaatat cccgaaagca catcttccac 3010621 attcgtcaaa tgcgccagca tggcggcttc cgcctgtgca ccgttcccgg cagccacagc 3010681 attgtaaatc cgttcgtgct cctcatacag ccgctgaacg gaggtcttct tggaaaacag 3010741 ccagattttc ctcgtttccc tcattgtttc cagcagcaat gatgacacgt gattcatcaa 3010801 gtgtttaaga agttcatttt gagaagcgtc cgcaagcgca agatgaaatg caaagtctgc 3010861 tttctctccc agctccccgt ccgcttcaat gctgcccatt tcctttagtg catcctgaat 3010921 tctttcgaga tctgcttctg tccttttttc agccgctagt gaagccacgc cgatttcaag 3010981 cagttttctg acctcgagca gctgcttgac gtcctctttt ttcatcagaa gggcggctga 3011041 gagcggctga gaaatttgat tgagctcaaa ttccttcaga tacgtgcctt ctccctgttt 3011101 catttcgaca agccccatcg cttttagcgc agaaagtgct tcgcgaaccg ctgaacggct 3011161 gacttgaaag ctctcagcaa gcgcctgaac agagtccagt ttatcccccg gcttcaattc 3011221 gccatttttg atcatatcta atagggcatc cgctacttct tcatatattt ttttgtttta 3011281 atctgtttat atttcaatgc aattcacccc gtaacttgta ggtctggctg tttacgatct 3011341 attatactct gttttgtggg ccgccaaaag attttgacta ttttgtcaaa aagtcttgta 3011401 ctttgatttt tttcaaaata taatgctagg taactggtct tattacccag tcatcagatg 3011461 atcatatcat ctatagaaac cgcttacata tggcgccagt ttatgtttca aggaggggtt 3011521 tgggatgcaa tggacacagg catatacgcc tataggggga aatttgctat tatcagcgct 3011581 tgccgcactt gtaccgatta ttttcttttt ttgggcactc gcgattaaac ggatgaaggg 3011641 gtatacagca ggcttggcca cattggggat cgcccttatc attgctgtat tggtttatcg 3011701 tatgccggcg gaaaaagcgc tgatgtccgc gacacaagga gccgtatacg gattgttgcc 3011761 gatcggctgg atcattgtga cgtctgtttt tttgtataaa atcactgtga aaacgggaca 3011821 gtttgatatc attcgcagct ctgttctctc gattactgat gaccgacggc ttcaagctct 3011881 cttgatcgct ttttcattcg gggctttttt agaaggggca gcaggcttcg gagcgccggt 3011941 cgccatttct gccgcgctgc tggtcggtct cggctttaat cctctttatg ctgcggggat 3012001 ctgtttgatc gccaatacgg cgccggttgc ctttggggca attgggattc caattacagc 3012061 cgtagaaggg ccgacaggga ttccggcgat ggagatttcg caaatggttg ggcggcagct 3012121 gccgttttta tccgtattta ttcctcttta tttaatcatc atcatgagcg ggttcaggaa 3012181 agccttggag atctggccgg cgattctcgt atccggtgtt tcctttgctg ttgttcaata 3012241 tctcagttcc aattttttag ggcctgagct gcccgatgtt ttgtcagctc ttgtttcaat 3012301 ggctgcgctt gctgtgtttt tgaaatggtg gaagccgaaa acaacattcc ggtttgccgg 3012361 tgaacaagag tcggccgcct caattgaaac ggcgcgcaca aatccggcgg cgcctgcata 3012421 cagaggcgga cagattttta aggcttggtc gccatttctg ctgctgacgg cgatgatttc 3012481 cgtatggggc attccatctg tcaaatccgc gctgaccggg cattatgaag gctctgcggt 3012541 gttcttgaag tggctgaatg ctgttggaga aaaactgact ttttcccccg gtgtgccttt 3012601 tttgaacaat cagattgtca atgctgacgg tacgccgatt gaagcggttt acaagttgga 3012661 ggtgcttggt tcggccggca ccgcgatatt gattgccgca gtgctgtcaa aattcatcac 3012721 ggcgatttcg tggaaagact ggggaaccgt ttttaaagaa acagtccagg aattgaagct 3012781 tccgattttg accattgctt ctgtcgttgg ttttgcctat gtcaccaact cctcgggaat 3012841 gagcacgaca ctcgggatga cactcgcgct gacaggttcg atgtttacct tcttttcgcc 3012901 cgttctcggc tggctcggcg tcttcattac cggctcggat acttctgcca acctgctgtt 3012961 cggcaacctg cagaaagtca ccgcattatc agtcggcatg gaccccgttc tgtctgtggc 3013021 cgccaactct tcaggcggtg tcacaggaaa aatgatttca ccgcagtcga tagcggtggc 3013081 gtgcgccgcg gtaggactcg ccggaaagga gtcagatctt ttccgcttta ccattaaaca 3013141 cagtctgttt ttgctgctgc tcgtctgtat catcaccttt ttgcagcatc acgtattcag 3013201 ctggatgatt ccttaaaaaa atcctcccgt ctagggagga ttttatttat atcgctttct 3013261 cgctgccgat gacggaatat tcatttgatc gcgatatttt gccacggtgc gtctcgagat 3013321 ttggatgccg tgttgttcat acagcaaatc gacaagcttt tggtctgaaa gcggttttgt 3013381 tttgtcctct tgattgatca ggttttccag atgcgttttg actgcataat tcgacgcatc 3013441 tccatcacct gaagcctcgg cttttgctga gaaaaagagt ttcatctcaa acagcccgta 3013501 aggcgtttgt attgttttcc ctttaatggc ccggctcaca gttgattcat gaaggcttag 3013561 acagtctgcc acctctctga gagtcagcgg cttcattgcg cttcgccctt tcagaaagaa 3013621 atccttttgg cgtgtgatca gttcattgat aattctcgtg attgtctgtt ttcgctgccg 3013681 cagcgcgcgg ctcagccagc gccactcctg atatttcgca gataaatagg agacagtatc 3013741 ctgacaggag ccggatgata aaagcgttct gtactgcgga tgcagatcga tctcgggaaa 3013801 cgagcgggta ttcagttccg ctgcgatgtg cccatttttt acggtgataa aaatgtcagg 3013861 ctcaatatac acatcttgct ctggccgggc aaacagaagg ccaggtctag gatgaagagc 3013921 cgcgatatca tctgagatat cttgaatggt atgaagcgga attcccgtct ctactgaaag 3013981 cgttttccat tttttttgcg caaaagcatc aaaatgagct gaaaccagca tttccgcttg 3014041 ttcatttctg ttcggcagcc gctgtaattg aagaaggatg cattcctgca aagatctcgc 3014101 gccgattcca gccggttcta acgactggag ttttgccaaa acagcctccg cttccttggc 3014161 cgatacagat aatcgccgtg ctgcctcctc tatatcttct tccaagtacc cgtttgaatc 3014221 aagcgaatga atcagataat taaaaatctt tttttcagtg tttgtcagat tcatatcgag 3014281 tgactgctgt tttaacgcat cctgcaatgt tttttgcgga ttacttaatt gaaggcccgc 3014341 ttcctgtgca ttcatcctgt ttttgtttgt tttatggtaa gatagtggcg gtgtgtctgt 3014401 ttcctttcgt tcaataagag ggttttccag tgagagctca tcaatgtact cggcgagttc 3014461 tgccgaatga tagccaagca gcgtgatggc ctgcctgagc tcctgtgtca gttgaggctt 3014521 taatacttgt acttgctgaa gtttcatatc catcttgctc actccccttt cttcattgta 3014581 catgattgag atcacaccgt atacatttat gaaaaaggag ctgccaaaga aatgtctgaa 3014641 cttttttccg tcccttattt tattgagaat ttaaaacagc atattgaaat gaatcagtct 3014701 gaggataaaa tccacgcgat gaacagctac taccgttccg tcgtctcaac actagtgcag 3014761 gaccagctga cgaaaaacgc agttgtcctg aaacggattc agcatttaga tgaagcatac 3014821 aacaaagtca aacgtggaga atcaaaataa accttccgaa ttcgggaaga tgatgatcgg 3014881 ttaaagggct aacgttcgca tctatagggg aaatctgttt ataatggggg aaaaagggag 3014941 agaacacaat gactcatcaa atagtaacga ctcaatacgg caaagtaaaa ggcacaacgg 3015001 aaaacggcgt acataagtgg aaaggcatcc cctatgccaa gccgcctgtc ggacaatggc 3015061 gttttaaagc acctgagccg cctgaagtgt gggaagatgt gcttgatgcc acagcgtacg 3015121 gctctatttg cccgcagccg tctgatttgc tgtcactttc gtatactgag ctgccccgcc 3015181 agtccgagga ttgcttgtat gtcaatgtat ttgcgcctga caccccaagt aaaaatcttc 3015241 ctgtcatggt gtggattcac ggaggcgctt tttatctagg agcgggcagt gagccattgt 3015301 atgacggatc aaaacttgcg gcacagggag aagtcattgt cgttacattg aactatcggc 3015361 tggggccgtt tggctttttg cacttgtctt catttaatga ggcgtattct gataaccttg 3015421 ggcttttaga ccaagccgcc gcgctgaaat gggtgcgaga gaatatttca gcgtttggcg 3015481 gtgatcccga taacgtaaca gtatttggag aatccgccgg cgggatgagc attgccgcgc 3015541 tgcttgctat gcctgcggca aaaggcctgt tccagaaagc aatcatggaa agcggcgctt 3015601 ctcgaacgat gacgaaagaa caagcggcga gcacctcggc agccttttta caggtccttg 3015661 ggattaacga gggccaactg gataaattgc atacggtttc tgcggaagat ttgctaaaag 3015721 cggctgatca gcttcggatt gcagaaaaag aaaatatctt tcagctgttc ttccagcccg 3015781 cccttgatcc gaaaacgctg cctgaagaac cagaaaaagc gatcgcagaa ggggctgctt 3015841 ccggtattcc gctattaatt ggaacaaccc gtgatgaagg atatttattt ttcaccccgg 3015901 attcagacgt tcattctcag gaaacgcttg atgcagcgct cgagtattta ctagggaagc 3015961 cgctggcaga gaaagttgcc gatttgtatc cgcgttctct ggaaagccaa attcatatga 3016021 tgactgattt attattttgg cgccctgccg tcgcctatgc atccgcacag tctcattacg 3016081 cccctgtctg gatgtacagg ttcgattggc acccgaagaa gccgccgtac aataaagcgt 3016141 ttcacgcatt agagcttcct tttgtctttg gaaatctgga cggattggaa cgaatggcaa 3016201 aagcggagat tacggatgag gtgaaacagc tttctcacac gatacaatca gcgtggatca 3016261 cgttcgccaa aacaggaaac ccaagcaccg aagctgtgaa ttggcctgcg tatcatgaag 3016321 aaacgagaga gacgctgatt ttagactcag agattacgat cgaaaacgat cccgaatctg 3016381 aaaaaaggca gaagctattc ccttcaaaag gagaataaat atggggaaaa caggatacat 3016441 tggtgctgcc attgttgtgg cagcttgtat cattattttg tcggccgtgg tatgtttacg 3016501 ggacacagtc tattaccagc ctatgcgctg gactggcatc atactgtttt tcgcgggaat 3016561 tgtgatggtt cccgcatact cagcaaaaag aaaacccgga aaagagaagt aattctcttt 3016621 tccgggtttt tatgtttatt ataatcttcc cgcgcgaata tcgtctgtca ttccctcata 3016681 aggagccttc gaaatcactt cttcgttgtc gactccttca tttttcagaa atgtaatttc 3016741 cgcaaattca ggtacaacgt attttggata cgtttcatat ttttcgcggg attctttcat 3016801 caaatcaatg tggtcatttt ggtagcaaac cgtaatttca ggatgttcat gcacccattt 3016861 cgggaagaaa ataatgccat gcatgcgttt ttcatttggc ataaagttta atgaaacatc 3016921 cgtgccagtc ggctctgtcc aagacacttt atatacgcct tctgtcagtt tgacaatatt 3016981 cacttcctga tctcgaaccc agcgtccggc aaccattccg ctatgaattc tataatcaat 3017041 tgtatggtcg tttttaatat aaatctcgta ttcccatccg ttttcatacg tataaatcat 3017101 gtggcttccg ataaagtttt ccatcttaca cactctcctt agtcttttac tgtacttcat 3017161 aaatgtctag tagaacgtaa tcaggggttc tttctgcgga accgataaac aagcggtcat 3017221 ggagccattg atagacttca ctgcctgttt caaacgtcgg taccgtacga aaataaacat 3017281 gctccggttc aataatttcc ccggctgccg cttgttttcg aaacggcttg ctgacttgcc 3017341 gtattccatt gttttcaatg taaatcagtt catgatctgc tgtttcaatc acatacctgg 3017401 cagataaatc tgttctgccg ttagcgcgaa tcatttgtga atcggcaccg cccggcaaaa 3017461 tacgtccctt tacttccccg gttattgttc ccgaacgaat cggaatgaat catctcagtc 3017521 ccaggcttgt ctcaccaatc gtgataggcg gatcaacctt gatttctaaa gaggcgaatg 3017581 gttttaaaac cggcttcttc acgagaacca cctcaccttc agaaaaaatc atgtaactat 3017641 ttacatgttc actttaacac cattgcagtt aactgtcaaa caataggaac ataaaaaaac 3017701 aaggactgtt tgaagacagt ccttgtctga agctagcttt gataagcaag atatgtgctg 3017761 acagtgcttt tggcaagaca ggcagaggaa tctataatcg gaatctcact ttgaatatga 3017821 tctaacaccg catttaaatc cgtgcaggct gaaatgatga tgtctgcatg ctgactgatt 3017881 tcttcatata gcgtctgcca caatgcttgt gtatgctgca tatgatttgg ctgtttgatt 3017941 gcggcgataa gctggttcac agcctgctgc caatggtcct tgtgaataac ttcttgtcca 3018001 tttcccttca gaactttttg gtagatggcg gattggatgg ttggctctgt tcctaaaacc 3018061 accgcttttt ttgcgggatg cggaatctct tttatcgttt cctcaacaat atgcaacata 3018121 ggaactgaca atgcctgctg aatctcttca tagtagacat gcgccgtatt acaaggcagc 3018181 gcaatgaaat ccacgcctgt tttctcgagc tttaccgctc cgtcgataat cgcttttttc 3018241 atctcgtcat ggtcaattgg acgatctgca tagaagggcg tcgggcatga atagatcatc 3018301 atgtgcggat agtcaatatc gtttgaagcc ccatacagct tctgacagta atcaatcacc 3018361 ttatcaataa acggcgaggt cgatttcggc cccattccgg ctaatattcc gatcatcaaa 3018421 ttcattcctt tctacttcgt acggaccgct tcttcctctg agccatcctc atagaggata 3018481 aagcttttcg cagcatcctc acctaatgta aactcgactt caacagacaa tgctcgcaga 3018541 aagaaacggg tttccgagga aggaaataac tccagtctca gctgtccggc gatctccaaa 3018601 taaagccgtt cattctcggt tgtcacctgt gcagccgtcc catcctgcaa caggtagctg 3018661 ccaacatagc ggctgtatat cgccgtatca attgcttttt tctttttatc agcaggacgt 3018721 tccgggacat catatggctg gccaaataga atatgttccg ccgccttcag aatcgcttgt 3018781 tcatattcag tatcctcttc cttattactc aaatagatca gcgttttacg atgatcgata 3018841 tatcggatca tcatcgtcga atagccgggc catcctccgc tgtggctgac aatccgccct 3018901 ttttcaggac tgttttgcag cacccagcca aagccataat caattgtttc tccattgttg 3018961 aggcgcactg gagaaaacgc agattcctta gaagccttgc tgatgaaatc gtcctgatat 3019021 aaagcctgat caaatcgaaa caaatcgctt gtgacagagt taaccgtccc atctccctgt 3019081 atgccatcga gatacacaac atagttcgtt tcctccagct catcagggag gacgtatgtt 3019141 tcggaatgta catcatacac atatccatat gcataatgat caattcgctc aggcgaaagc 3019201 ctcctgttat acactcttgt ttcattcatg cctgccggta aaaaaatact tgtttttata 3019261 aaatccgcat agctcatgcc agatgctttt tcaatgataa ccgccagcag cacatacccc 3019321 gtattgctgt acatccagcc ttcattcggt tcaaaataac cagatagccc ctcattcatc 3019381 agcatatcga caatatcctg attcaccgca atcttgtgtg aatcccaatt ggcaaaaaac 3019441 catcccatat aatcaggaag ccctgacgta tggttcaata aatgccgaat cgttacgccc 3019501 tgatacggaa aaccgggcag ccagcgatcc actttatcct catagccaag aatccccttc 3019561 tcctccagca agatgattcc caatgctgta aaaggctttg acaaagacgc taactcaaac 3019621 aaagagttgg ttttcaacgg gcgtttttcc gtcatttccg catagccaaa agagtggtga 3019681 tataaaatat cgccaccctc cgcagccaga accgtcccgt taaactgatg tttttcgcct 3019741 aatgtctcaa ataacgtctg aagatgcttt cttttattct gcttcattcc tccacctccc 3019801 atatctctgt acgttactaa cctactaacg tttcaaatat tttgaaaaat ccttcagtta 3019861 gagatccttt ttaacccatc acatatacct gccgttcact attatttagt gaaatgagat 3019921 attatgatat tttctgaatt gtgattaaaa aggcaacttt atgcccatgc aacagaaact 3019981 ataaaaaata cagagaatga aaagaaacag atagattttt tagttcttta ggcccgtagt 3020041 ctgcaaatcc ttttatgatt ttctatcaaa caaaagagga aaatagacca gttgcaatcc 3020101 aaacgagagt ctaatagaat gaggtcgaaa agtaaatcgc gcgggtttgt tactgataaa 3020161 gcaggcaaga cctaaaatgt gtaaagggca aagtgtatac tttggcgtca ccccttacat 3020221 attttaggtc tttttttatt gtgcgtaact aacttgccat cttcaaacag gagggctgga 3020281 agaagcagac cgctaacaca gtacataaaa aaggagacat gaacgatgaa catcaaaaag 3020341 tttgcaaaac aagcaacagt attaaccttt actaccgcac tgctggcagg aggcgcaact 3020401 caagcgtttg cgaaagaaac gaaccaaaag ccatataagg aaacatacgg catttcccat 3020461 attacacgcc atgatatgct gcaaatccct gaacagcaaa aaaatgaaaa atatcaagtt 3020521 cctgaattcg attcgtccac aattaaaaat atctcttctg caaaaggcct ggacgtttgg 3020581 gacagctggc cattacaaaa cgctgacggc actgtcgcaa actatcacgg ctaccacatc 3020641 gtctttgcat tagccggaga tcctaaaaat gcggatgaca catcgattta catgttctat 3020701 caaaaagtcg gcgaaacttc tattgacagc tggaaaaacg ctggccgcgt ctttaaagac 3020761 agcgacaaat tcgatgcaaa tgattctatc ctaaaagacc aaacacaaga atggtcaggt 3020821 tcagccacat ttacatctga cggaaaaatc cgtttattct acactgattt ctccggtaaa 3020881 cattacggca aacaaacact gacaactgca caagttaacg tatcagcatc agacagctct 3020941 ttgaacatca acggtgtaga ggattataaa tcaatctttg acggtgacgg aaaaacgtat 3021001 caaaatgtac agcagttcat cgatgaaggc aactacagct caggcgacaa ccatacgctg 3021061 agagatcctc actacgtaga agataaaggc cacaaatact tagtatttga agcaaacact 3021121 ggaactgaag atggctacca aggcgaagaa tctttattta acaaagcata ctatggcaaa 3021181 agcacatcat tcttccgtca agaaagtcaa aaacttctgc aaagcgataa aaaacgcacg 3021241 gctgagttag caaacggcgc tctcggtatg attgagctaa acgatgatta cacactgaaa 3021301 aaagtgatga aaccgctgat tgcatctaac acagtaacag atgaaattga acgcgcgaac 3021361 gtctttaaaa tgaacggcaa atggtacctg ttcactgact cccgcggatc aaaaatgacg 3021421 attgacggca ttacgtctaa cgatatttac atgcttggtt atgtttctaa ttctttaact 3021481 ggcccataca agccgctgaa caaaactggc cttgtgttaa aaatggatct tgatcctaac 3021541 gatgtaacct ttacttactc acacttcgct gtacctcaag cgaaaggaaa caatgtcgtg 3021601 attacaagct atatgacaaa cagaggattc tacgcagaca aacaatcaac gtttgcgcca 3021661 agcttcctgc tgaacatcaa aggcaagaaa acatctgttg tcaaagacag catccttgaa 3021721 caaggacaat taacagttaa caaataaaaa cgcaaaagaa aatgccgata tcctattggc 3021781 attttctttt atttcttatc aacataaagg tgaatcccat atgaactata taaaagcagg 3021841 caaatggcta accgtattcc taaccttttt aggaatattg ctgtttatcg acttatttcc 3021901 aaaagaagaa catgaccaaa aaacaaaatc aaaacagaag ccggactacc gggcggcata 3021961 tcattttacg acgccggata aatggaaaaa tgaccctcaa aaaccgatct attttgatgg 3022021 caagtatcat tatttctatc tatataaccg ggattaccca aaaggcaacg gcacagaatg 3022081 gcgccatgcc gtctcagagg atttggtgca ctggaccgat gaaggcgtgg cgattccgaa 3022141 atatacaaac ccggacggtg atatttggac cggttccgtc gtggtggata aagagaacac 3022201 agccggcttc gggaaaaatg cgcttgtcgc gattgtgaca cagccctcag ccaaagacaa 3022261 aaaacaggaa caatatttgt ggtacagcac agataaggga aaatcattca aattctacag 3022321 tggcaacccc gttatgccta atccgggcac agacgatttc agagatccga aagtcatatg 3022381 ggatgaccaa gataacaaat gggtcatggt catggctgaa ggatcaaaaa tcggctttta 3022441 tgaatccgat aatcttaagg actggcatta cacaagcgga ttcttcccag aacaggcggg 3022501 aatggtggaa tgtcccgacc tctacatgat gcgggcaagc gacggaacga ataagtgggt 3022561 tctcggtgcc agcgcgaatg gcaaaccgtg gggcaaacca aatacgtacg cctactggac 3022621 cggaagcttc gacggaaaag aattcaaagc ggatcagact gaagcccaat ggcttgacta 3022681 tggcttcgac tggtatggcg gtgtgacgtt cgaagacagc aaaagcacag atccattaga 3022741 aaagcggtat gcgcttgcct ggatgaacaa ttgggattat gccaacaaca ccccgacaat 3022801 gaagaacggc tttaacggca cagattctgt catacgcgaa ctccggctga aggagcagga 3022861 tggaacatac agcctcgtct cacagccgat tgaagctttg gagcagctga ctgtttcaac 3022921 tgacgaaata gaggatcagg atgtgaacgg atcaaaaaca ttgtcgataa caggtgatac 3022981 gtaccagctt gatacggatc tttcttggtc agagctaaag aatgcaggcg tcaggctcag 3023041 agaatcagaa gaccaaaaac gccatattga tgtcggcatt ttcgctgaag gcggctatgc 3023101 ttatgtcaat agagcagcca caaatcagcc tgacaaaagc aatacctatg tcgaaagcaa 3023161 agctccttat gatgtaaaca aacgtaaggt gcatttgaaa atacttgtcg ataaaacaac 3023221 gatagaagta tttgttggcg acgggaaaac cgttttttca aatgaagtct tcccaaagcc 3023281 tgaagataaa ggaattaccc tttattctga cggcggcaca gcctccttca aaaatataac 3023341 agtgaaacac tttgattcga ttcatgaata aaaacagggg cggcgcaggc tgcccctgtt 3023401 tttttattag gagcggtatt ctctgttaca tattgggcat tgtaaggaat ataaggctgg 3023461 tttcaaagga ggaagcgaat gtctaaacaa ggaaattttc aaaaatcaat gtcgctgttt 3023521 gatctgattt tgattgggat gggagccatc tttggatcag cgtggctgtt cgctgtcagt 3023581 aatgtcgctt caaaagcagg gccctccggc gctttttcct ggatcctcgg aggagccatt 3023641 attttgttaa tcgggcttgt atatgcggag ctcggagccg ctctgccccg taccggaggc 3023701 atcattcgat accccgttta ttcacatggc caccttgtcg gctacttaat ttcgtttgtc 3023761 acgattgtcg cttatacaag cttgatttca attgaagtga cagctgtgcg ccagtatgtg 3023821 gcctattggt ttcccggcct gaccattaaa gggtctgatt cgcctaccat ttccggctgg 3023881 atcttgcagt ttgccctatt atgcttgttt ttcctgctga attattggag cgtcaaaacc 3023941 ttcgctaagg cgaatttcat catatcgatt tttaaatata ttgtgccgat taccatcatt 3024001 attgtgctga tctttcattt tcagccggag aatttatccg ttcaaggatt tgcaccgttt 3024061 ggatttacag gtattcaggc tgccatctcg acaggcggcg tcatgtttgc gtatctcggc 3024121 ctgcatccga ttgtatctgt agcaggtgaa gtccaaaatc caaaacgcaa tatcccgatc 3024181 gctttaatca tttgcatcat cgtttcaacc atcatttata ctgttttgca ggtcaccttt 3024241 attggtgcaa tcccgacaga aacactgaaa catggctggc cggcaattgg ccgggagttc 3024301 tcattgccgt ttaaggatat tgcggtcatg ctcgggttag gctggcttgc aacgcttgtc 3024361 attttagacg ccattctgtc tcccggagga aacgggaata tctttatgaa tacgacatcc 3024421 cgccttgttt acgcctgggc gcgtaacggc acattatttg gcatattctc aaaggtcaat 3024481 aaagatacgg ggacaccccg cgcttcgctt tggctttcgt ttgccctgtc cattttctgg 3024541 acacttccct ttccttcgtg gaacgcgctc gtcaatgtct gttcagtcgc gctcattctt 3024601 tcatatgcga ttgcacccat ttcttcagct gcgctgaggg tcaacgcgaa ggacttaaac 3024661 aggccgtttt atttaaaggg aatgagcatt atcgggccgc tttcctttat atttacagcg 3024721 tttatcgtgt actggtcagg atggaaaaca gtctcctggc tgctcggttc acaactcgtg 3024781 atgtttttga tctatctctg tttcagcaaa tatacgccta aagaagatgt cagccttgct 3024841 cagcagctga aatcagcctg gtggcttatc gggttttata ttatgatgct gatcttttcc 3024901 tacatcggtt ctttcggaca tggtttaggg attatcagca atcccgtcga cctcatttta 3024961 gtcgcgatcg gctcacttgc gatttattac tgggcaaagt ataccgggct cccaaaagcc 3025021 gccattgatt atgataaata aagaagcaag aggttttctt gcttctttat tctttacaaa 3025081 caaacataca cgcgataaaa tgaatgagag tcagtcatta ctggaggtgt tcctcatgcc 3025141 aaaacaaaca tcgggtaaat acgaaaaaat attgcaggcg gccatagaag tcatttctga 3025201 aaaaggcctc gacaaagctt ctatttctga tattgtcaaa aaggccggca ctgcccaagg 3025261 aacattctat ttgtattttt catctaaaaa tgccctcata ccggccattg cagaaaatct 3025321 cctcacccat acacttgatc aaatcaaagg taggctccat ggggacgagg atttttggac 3025381 cgttttagat atattaattg atgagacatt tctcattaca gaacgccata aggatattat 3025441 tgtcctctgt tattccgggc ttgcgatcga ccactccatg gaaaaatggg agacgatcta 3025501 tcagccttat tattcctggc ttgaaaaaat catcaacaag gccattgcaa accatgaggt 3025561 aacggaagga atcaattcaa aatggacggc cagaacgatt atcaacttgg tcgagaatac 3025621 tgcggaacga ttctatatcg gatttgaaca agatgaaaat gttgaagtgt ataaaaagga 3025681 aattttcact ttcttaaaac ggagcttagg tactgcttaa aaaatgactg ggtaacaccg 3025741 ctcatttttt aatgccctaa aaatgactga cgttcattca taaaatagag aggtgtttca 3025801 tttgaattgg gttcttgttt ttattgcagg gcttttagag gttgtttggg cctcttccct 3025861 caaacatgcc gattcgcttt tggattggat catcattttt atcttaatcg cggtcagctt 3025921 tatcctgttg atccgctctt atcaaaaaat cccgatggcc gcggcgtaca ctgtgtttgt 3025981 gggaatcgga accgtcggaa catatctgac tggaattgtt ctgggcgaat ccttctcagc 3026041 agcccaaatg ttctttttag ctttattgct ggctggcatt ttaggaatga aattatttac 3026101 gaaagaaagc aaatctcagc cgggaggtga aaaataatgg catggttttt attagtgatt 3026161 gccggcatag aagaaattat agctgccatt gccatgaaat atatagacgg aacaagaaaa 3026221 aaatggccga tcattgtgat gactgttgga ttcggcttat ccttttactg cctgtcccaa 3026281 gcgatgatcg tcctgcctgc cggagtcgca tatgccgtct ggactggcat tggaagcatt 3026341 ggtgtttcgg cggtcgggct catctggttt aaggagcggt ttcagctttc acaggtgatt 3026401 tcactttgcc ttatcctagc cggcgtcatc ggcctgcgtc ttacgtcatc ttcataaaat 3026461 caaggcatat acagctgtat atgcctttgc cattaagctt cgtgatgttt ttgaagatga 3026521 agcggcggcg ggatgagcca gcctttgttt tttagcagcc ttaagtattt tgcgccggtt 3026581 gccgctttcg acatatgaaa ttgcccaaac atcatggcaa tatcctcacg aatcgattgc 3026641 cccatcattt tgctgcatgt cacaagacct gcagcatttt ctgctgccgc ggaagccgcc 3026701 acatccggat cgagaaaccg tgcaccaggc ggaatatcgt taagatctgc tgtcggcggt 3026761 tcaggagaag ccggcggcag cgccaccccg ttttctttca ggatcgtgct gacctgtttg 3026821 atttcatctt ggcatttctc aatagactca cgaagcagct tcttcaggtc gtcatcaccg 3026881 acatgattca atagcatttg gtaattgccg accattttat tgcccgccat cacataactc 3026941 cacaagccga atacctcacc gtaatgcatc ggttcatcct gcggatttcc gcttaaaata 3027001 cccatgctca ttctcctccc atattcaata ttgcacattt cataacgtgc ccaagcggag 3027061 gaacatttat gtttcagcgg aaaagattta tgaaatgaaa caaaacaaaa aagacaagag 3027121 tggcaagttg ccaaaccatt gtctttcctg ttgtttgatt ggacgcactg aagggattcg 3027181 caccccgaca gacaagatac cggaaaccat tcaagtgctt tttagtatga gtcattgatt 3027241 ctgtctttaa taaactttaa cgagatggcg ggatgctttg cggaaaacga aatacatttt 3027301 cggggtcata tttcgccttt atttctcgaa gccgcgcaaa gtttgcgcca taatattctt 3027361 ttccgaagtt ttcaatgttt tgatctggaa cattaacata tgaacctgct acatatggtt 3027421 gcatcagctg acgcactctt tcaactgatg caagatttga atcttcttgt gatttatttt 3027481 tccaactagc cgtccattcc gtataaaata atggatggcg ccaaaaaaag gcagtttcgt 3027541 ctttagggac tctgcttata gcaccacccc aattgataaa aaagaaattg gcttctgttc 3027601 cagtagcatc ttccaaaaat tttctcatga ttgaaatggg ttcgtcagac caaaaatcat 3027661 gaccccatgc cgaggagaat ttaacactct gatcatttct gccagggatg ggttcgtcag 3027721 ggtctaagaa atctatagca tctggatagt ataatgtttt gatatctgct tctgttggag 3027781 ttcccgcatg taataaaggt tttaataatc gaatcaattc agttttcgaa ccgaggaaaa 3027841 ttccttctgc atgacacaaa ccatttattt tgctgtaaat ttcaaggtag catcctaatc 3027901 gttcatctac aaacggagcc catttctgcc aagctttaaa taccgtttct aattgttccc 3027961 acggccagat aatattgaag acggttgcag ttttaggggc acgatgaact ttgaatgtat 3028021 attgggtatt atatccaaag ttacctcctc ctccgcctct agaagcccat agcaaatcct 3028081 cattgtgaga ttgatctgcg tgaataatcc ttccttttgc atctaccgtt ttcagcgcga 3028141 gaaggttatc acttataagg ccaatcgatc gtgagagtac accaaatccg ccgcccatcg 3028201 taattccccc gattccaact gttgggctat ctccaaacgg agccataaaa ccgtctcgag 3028261 ctaatccctt tacaagcggg ccaacgggaa taccagtttg aacggttgca atagcgtttt 3028321 cttcatctaa gaaaacttta ttcatgtcac tcacatcaat aacaattcct ccacttacta 3028381 ctgaaaggtt cttatctaaa gcatggcgac cgcttctgac acgtaagggc actttattct 3028441 cacgagccca tttaatggca ttacttacat cgtatgaatt ttgcgcaaaa acaaagacaa 3028501 gaggatagac atccacataa gggttccaat tcttaatagc ctctgtatag ccggggtctc 3028561 ctttgaagat tacacgccct gtcaactgtg ttgatcccat atattatttc actcccaaag 3028621 aaattcgatt cagatactaa aatatgcagg agctggataa tcgcatagac aaatgatcta 3028681 cgaactataa atataatacg ctaaggcctt tttcgtcggt gaggtctgct gagaaacatt 3028741 tttcaaacaa ttttgagcaa acttcctgtc caatcctcca acaagcgttt tttcttatcg 3028801 tttttaggag cagtgtccag tttttttcgg agtgaatatt cgtttaggcc aaaagaaaag 3028861 agagatgaag aagtgtttag taccagaggt atacatccat acaacagact ctagatcatc 3028921 atatactgaa tgtatgtaga aaggagacat cagctttggc aaaatatcgg attatgacct 3028981 ttgacggcgg cggtacctta ggtgctttaa gtttacaact attaaacaga ttggctaggc 3029041 aaaacccgaa gttaattagt cgaacccatg tattttcggg aaattcaatc ggttcattta 3029101 ctgcccttgc attagcaagc ggaagatctc cgagggaaac acttcagtat tttgaggatg 3029161 aaatcctacc cgcattcagc atttcccggc caggcggacc tgttttcaac caacaattac 3029221 cctattccgg ttttattaaa gcggtaagaa attttttccc agcagatctt caacttatag 3029281 atttaagaaa acgaattgtt gtcccatcat tcaaattata ctctcaaaaa ctggaccgtt 3029341 ggactcctgt cttatttcac aattttcccg gctctcccta tttaaatgaa aaagtgagtg 3029401 atgtcatact gcggagcagc ggtgctcccg cgacgcaacg cgcctatcaa aactatgtgg 3029461 acggatatgt agtagcaacg aatcccagta cagccagtat cgcgtttgca gttggtaaag 3029521 ccaacgtgcc attggatcaa attgcggtat tgtccatcgg aacaggtgaa gccccgactc 3029581 ggttaagaag agatacgagg ggatggggaa tggtaagtgc agataacata cgtcccgaaa 3029641 atctgaagaa ccttcctcca aattggggag tccttttgga caggtcgcct aatgaacctt 3029701 tactgccatt tcttcagatg attgctggcg gtaatgggta ctatgaatcc atggtcagtg 3029761 cgaatcttct gggagatcgt tttttccggt tagatccgcg gattccgaac ttctccaaaa 3029821 cggaccctgc cgtcgttccc gctgtcattg aaattgcgaa caaaacaaac ttacagcctg 3029881 cgaatcaatt tatagagaag aactggggga gcaaataatt atttatttta aatcaattct 3029941 cgcttataca attttgtccg agagaagatt ctcaaaataa atacaggcaa tgggtagaac 3030001 cggatttttt taaaggtttg ttaatcacaa gctaataaga tgaatgaaaa aatcaattca 3030061 tacttcttct tttgaaagtg agggttcaaa ctaaagaatg taattgaaat gttactctaa 3030121 ggtatgcaat tccctttttc acacaaaaaa agacaagagc ggcaaatcgc caaacccttg 3030181 tctttcctgt tgttctattg gacgcgctcg gagggattcg aacccccgac agacgtggta 3030241 ccggaaacca ccgctctatc caactgagct acgagcgcat atagactgcg ttatgagaac 3030301 gtcagcacaa ctaattatac gataattcct ttcaaataac aaccctctat ttcgagaggc 3030361 cgttttttaa atagacaaag catcttaatt ggcaatctga catacgatgg tttgaacccc 3030421 tgtatttttg gggaaaatgg gaaaaagaga cgactttgca tatcaggcca gctttttgtt 3030481 tgacctttat tgaccaaaaa tgtatcatgt aactacatac ttacctaaaa ggtgaaggag 3030541 gagcattatg aatttaatac ctacagtcat tgaacaaacg aaccgcgggg aaagagcgta 3030601 tgacatttat tctcgtctat taaaggatcg tatcatcatg cttggatctg cgattgatga 3030661 caacgttgcg aactccatcg tgtcacagct tttattctta gcagcagaag accctgaaaa 3030721 agaaatttct ctttacatca acagcccggg cggctctatt acagccggta tggcgatcta 3030781 tgataccatg cagtttatta agccgaaggt atctacaatt tgtatcggta tggctgcgtc 3030841 aatgggcgcg ttcctgcttg cagccggcga aaaaggcaaa cgctatgcgc ttccaaacag 3030901 tgaagtcatg attcaccagc ctcttggcgg tgcgcaaggt caagcgacag aaattgaaat 3030961 tgctgcgaaa cgcattctct tgcttcgcga caaattaaac aaagtcctag ctgaacgtac 3031021 tggccagccg cttgaagtga tcgaacgcga cacagaccgt gataacttca agtctgctga 3031081 agaagcgctt gaatacggcc tgattgacaa aattttgact cacacagaag acaaaaagta 3031141 ataacacaac ctgcaagagc tgcgtctctt gcaggttttt ttcatttcaa ggaattgact 3031201 cccttattct atactgctcc cattcctcat gtaacagctc aagcgtcaaa tcactcgtct 3031261 gcctcacaac cagatcagca ccaagcatcg gctgtccttg accgacacca accgcaaaca 3031321 tccccgcaga tttgattgca gaaatgcctg cttctgcgtc ttctattgcc gcgcaatcag 3031381 caggggaaac atcgagcatc gctgcagctg ttaaaaagat gtcaggatca ggcttcccct 3031441 tcgcaagagt cgtcggatca acaatggcat gaaaatcatc gataattgcc aagcgtctta 3031501 aaatcttagg agcattgcga cttgaagatg ctaacccgat ttttatattt tcgtttttca 3031561 attgacatag aagcctgcca atccccggta aaagatcttc cggcgtcaat ttgctgatca 3031621 gcatttgata atcgcgattt ttccgatgca taagctcttg tttctccgca tttgtatact 3031681 ttgtttccgc cccgccaaag atcaatatgc tttcaagtga ctcttctctg ctgattcctt 3031741 ttagcctttc attcatgtct ctgtcaaaag ggatatcgat ttgttctgcg atgtgcttcc 3031801 aagcgagaaa atgatattca gcagtatctg ttatcactcc gtctaaatca aaaatgaccg 3031861 ctttcatata ctaatgccca tcacagcttc ataaggtttg aggctaatac tctttaagtc 3031921 agcccgctcc tgcggatagt ttgaaattag cactttccaa cgctcatgaa tcagttctgg 3031981 aggcgcttcg aacagagcct tttcttccga taaattcaca acgacaagaa gcttttcccc 3032041 tcgatattct cgaaggtaag aaaagacctg cggatcattc tcctgcaaca gctgataatc 3032101 gccatatatc ataatcttat attgctttcg taattgaatg agcttctgat agtaaaagaa 3032161 aatcgaatct tgatcttcca aagactcttt cacattgata tcttgatagc gggaatttac 3032221 cggtatccac gggtctccgg ctgtgaatcc cgcatgtttt ccggcatccc actgcatcgg 3032281 tgttctcgca tgatcccttc cttttatcat cacggctttg acaaactctt tttctgacat 3032341 cgttttgttt tcgacgacta gttcacgata tgcattcttt atttcaagat catcatacat 3032401 ctccagcggc atatcgctgt tgaccatgcc gatttcttct ccctggtaaa taaacggcgt 3032461 tcctttcatg ccgtgcagaa ccgttgcaaa tgccttcgca cattccttac gcagtttcct 3032521 gtcattgccc cagcgggaaa taaccctcgg ctggtcatgg ttctcaaaat aaagggtatt 3032581 ccagccgaca ttcattaacc cggtctgcca ccttgtcatc gtctttttta aagcaatcaa 3032641 atcaaacggc ttgatctgcc atttcccatt tggcgagttt tgttctttat caatatccat 3032701 atgttcaaat gtaaagatca tattcagctc ttgcctgctt gcatctgtgt actttttcgc 3032761 ctcttcaata tcagagccgt ttgcctctcc gactgtcatg cagtcgtaat gagaaagcac 3032821 ttccctgttc atctcttgaa taaactcatg aagacgtggg ccgttagagt gataacggcc 3032881 gacaatatag ctgcggctgt gatccgtttc gtagtccgga aaatcggtgt atttagaaat 3032941 agagccaatc acatccatcc gccagccgtc aacgcctcta tccatccaga atctcattac 3033001 atcataaact tcccggcgaa cggcttcgtt ttcccaattt aaatcaggct gttttttcga 3033061 aaagtagtgc aaataatact gccctgttcc ttcatcgtat gtccacgctg agcctgaaaa 3033121 gatcgatccc caattattcg gctctgagcc gtccggttta ggatctttcc aaagataata 3033181 atcccggtaa ggattgtcct tcgacttgcg gctttcagca aaccaagcat gctcatctga 3033241 tgtgtggttc acgaccaaat ccatgacgat tttcattccg cgtttatgga cttcatcaat 3033301 cagctgaaac atatcttcat ttgtcccaaa cttttcgtac atgtttttgt aatcgctgat 3033361 atcatatccg ttgtcatcct gcggggaatc aaataccggg gagagccaga tgacatccgc 3033421 cccgaggttt ttgatgtaat ccagcttttg aatcacacct tgcaaatctc cgaatccatc 3033481 tccattggca tcataaaaac tgcgcgggta aatttgataa acgacagctt ctttccacca 3033541 ttcactcatt aggcgttctc ctttcacatc gtccctgtag gacaaccggt tcctcataaa 3033601 cgttcatgtg cagcggctcg ccttttacaa gctcaaaaat aacgcgcttt tcgtcaaccg 3033661 tcacattgat taatcgattt cgataattga tgttgaatga atattcgtcc cattctttcg 3033721 gcaaaaacgg agcaaatgac agcgtctcat tcgcggtgcg catgcctgca aagccatgaa 3033781 cgattgccag ccagctaccc gtcattgaag taatatgcaa gccttcttcc gtatcatgat 3033841 tgtaattatc aagatcaagc cttgctgtgc gcttatataa ttcgagcgct ttcttttcca 3033901 gcttgagttc ggctgcgaga atcgcatgga cagagggcga taggcttgat tcatgaacag 3033961 tcatcggctc ataaaattca aaatttcgcc gtttttcttc cattgtaaaa cggtcattaa 3034021 aaagataaat gccttggaga acatctgcct gcttaataaa attggagcgg agaatcttgt 3034081 cccatgacca attctggtaa agaggccgtt ccgctggatc taattcgtca actgtttgca 3034141 ggtctttgtc caagaacgtg tcatgctgaa cgaaaatttg cagttcttca ctaaatggat 3034201 agtacatgtg ctggatgatt tctctccaga cttccaattc tacttcctgc acatccagat 3034261 ggcggcgttt ctccgctgag atactttcga gactttgtag agtatactcc aacgtccaag 3034321 ccgcaatgac attcgtatac caattgttgt taacgttgtt ttcgtattca ttcggccctg 3034381 tgacgccatg gatcatatac ttattttttc gtttcgagaa gtgaacacgg tcggcccaaa 3034441 atctgctgac tgccacaagt acgtctatcc cgtattcttc catatagtta cggtcgcctg 3034501 tataattgat ataattgtag atcgcataac agatcgcgcc attgcggtga atttcttcaa 3034561 aggtgatttc ccattcgttg tggcattcat cacctgtgaa cgtcaccatc ggataaagtg 3034621 cccccttcat ccccaatttt gcagcgtttc gtttggcagc ctccaactga tgatagcgat 3034681 acaaaagcag gtttttcgtc acctccggct cggctgtcgc caaatacatc ggaacggcgt 3034741 acgcctcagt atcccaatat gcggcacctc catatttctc gccagtaaat cctttcggcc 3034801 cgatattcaa acgggcatcg cccccgtaat atgtcgagaa taactgaaag atattgtagc 3034861 ggattccttg ttgaagctcc tcatctcctt taatctcaat gtccgctttt gcccatcttt 3034921 ccttccatcg atcagtgtgc ctccgttttg catcttcata gccgttctct accacatccg 3034981 ccaaaagctc cttggctttc gataaaagct cttcctcccg aaaatcacgg gaagtcgtga 3035041 caatcacaaa ctttttcaat gatgccttcg tttgataact gtagcgattc tcgacataca 3035101 tttcagtcgt tttaaagctt tcatggacaa aaccctccgt ctcgtttgcc attgcggcta 3035161 ataccgtgaa gcgcggtgtt ccaaatggat tttcgatcgt ttttgccgct aaatggccgc 3035221 tgtgagaatc agcacctttc gcttcctcct gccaaaactg ttcttggtag ttagaatctt 3035281 catttgccac atttccatcc aggtaaggaa caagcgtaat gacagcatct cccgtcaagc 3035341 actccgcttc ataatgaatc gcacagagtt cttttacagc aaggctaaga aaccgctctg 3035401 acctgattct gacggtttta tcttgaatgc ggacaacagc gcttcgccgc agaatcccct 3035461 ctttcatatt gagttctacc tcaaataatt cgattgggtt ttgatggaga tcgatttttt 3035521 caccgtcaac atataggcct atgcccataa agttcatcgc attgatcact tttccgaaat 3035581 attctggata cccgtttttc caccagccta ctcgcgtttt gtcggggaac cacacgcctg 3035641 caatatatgt gccttggtga ctgtcgcctg aatagccttc ttcaaaattc cctctgaccc 3035701 ccatatagcc attggcaaga gacgtcaggc tttccagcag ccgtgtatgc tccttattaa 3035761 atgtatttgt tttgattttc cattcatcaa tctcaaataa ccgctgattt atcatcattt 3035821 cctcccgaat gtaagtttcc attatcacgg cgggttttgg tcaaatatct aaatgcaaaa 3035881 gagatcatca aagtaacgcc acacgaatgg atcatcaata cagtaatcaa atcaaaatga 3035941 accatgccga tagcagctgc cgcaaatgcc ggcagtgctg atgcgcaaat cgctatagag 3036001 gccgcttcct tgaatgatgc aatagagacc atgtttgata tttttgtgat ccagaggcca 3036061 cctgcaagaa caaacgttaa caaaagctgg atcatagaaa ccaccgtata tgccagcatc 3036121 atgatcatcg gcttatactg tgccaaccac aatgtatcga tcaagacctc tacatcatgg 3036181 acgtttggtt tctcgagctt aacgtccatt ttcgcatagc caacagaaaa ccccgtttcg 3036241 ttttgatcgg tgatcaccag ttgatcaggt tgaaatatga tggcgttttc aaatccagtt 3036301 actttcaatc gcccattttc accgcttgtc tcatattcat gcttcatatc gactgccatc 3036361 acattctgcc catcttcaat cctctcagag ctcttcccgc ctgttagttt tccgttcctg 3036421 atttgaaaac cctgcaattg atcagcaaat tgatcattaa ctccttgaat cgctgacggc 3036481 atgaaagatg aaacgctgaa gcgatccatt ttcacaaacg aaaccgctaa cggcgccatt 3036541 aagcaggccg ttaaaaacag aaagagaaaa gagagctgca gccagctgaa ggtattccca 3036601 tagcggcaaa cacctgatgg ggatgcagcc gccttcaggc agcggatgat aaagctttta 3036661 ttctccagat tcttcattgg cattacccct ttgttccgcc ggctgtcaaa ccggacacaa 3036721 agttcttttg gagaaaaaag aatagaacgc atatcggcag tgcggctagt atggcaccgg 3036781 ctgcaaatag agctactttt tgctgctgcg gattagaaat aaaggattgt aatcctacag 3036841 cgatggtcag cctttccggt gagcgaagca gaaatttcgt cagcaaatag tcgccaaacg 3036901 gtgccataaa cgcccaaagc gcttgtaccg cgagcattgg cttaacaagc ggtagaacaa 3036961 ttgaagcgaa aatcctcaga tgtcccgctc cgtcaattcg cgcggcttca tcaatttctc 3037021 tcggcacagt atcaaaataa cctttcatca gccacgtgtt catcggaatt ccgccgccga 3037081 tatagatcgc tgttaaaaac cagtattgat cgagtgcgcc tattagcatc gccaagacat 3037141 aaaaagcagt cagcgccgcc attgtcggca ccatttgaat gattaaaaag aatatcaggc 3037201 tcttttttct gcctgcaaac cgatagcggc tgtacgagta cccggcaagt gtcacaatcg 3037261 taacctgcaa aaccatgacc gatagcgcga tgacaagtgt attgctgtac caattgagat 3037321 aaagcgtttc gtcaaatagc cgcttaaaat gatccaatgt ccaagaaccc gaaaaatcga 3037381 gctgaaaagc cgccgaattc cccacacgga aggctgatga tgccgtaatc agcaacggat 3037441 atataatgac aatacttaaa agcgtcaaaa ataaatacgt acagatttta ttaagcattc 3037501 tggcagtgct cgcgttcacc tacataacct cctcattgcc aaaagcattc gattttttga 3037561 aagcaatcag tgaaattcca atgacaatga aagaaattaa cagtgtcaca gccgccgcaa 3037621 cggaatattg gggtgatgtg cctgttgtca gtttataaat ccacgaaatt aagatatcgg 3037681 tcgatccggc cccggctccc gcactgcctg gccctccctc attaaataaa tagatgatcg 3037741 agaaattatt gaaattaaac gtatactgag taatcatcac gggtgctgtg gcaaataaaa 3037801 tcatcgggaa tgtaatatgc cgaaaacgct gaataaaagt ggccccgtca atctttgccg 3037861 cttcatacaa ttcacctgga atcgcctgaa gcactcccgt taccatgaca tatatatatg 3037921 gaaagccgag ccacgtttga atcataatga gggctgtctt tgtccagaaa ggatcggtct 3037981 tccacgcgat cgcaggcagc tcgacaaacg gcaggtgatt gaataatggt atcacctgtg 3038041 cattcaccgc tcctatgctg tcgttaaaca tgttggaaaa actcatgatt gtaataaacg 3038101 ccggaacagc ccatggaaat aagaaaatca ttcgaaatat ccgcttgcct tttataaaat 3038161 cctgattgac gaaaagtgcc gtcacaatac ctaaaatgat ttgcagcgtt gttgcacaga 3038221 ttgtccagat aaccgtccag cccagtacat tcacaaatgt ttcacgatag gagccaagga 3038281 aaaaaatatt taagaaattt ttaaacccga cccagtcaat cagacgatta ggcggaatat 3038341 gataaaaatc atagtttgtt aatgcaacaa acagagtcac caaaaccgga aaaataatca 3038401 caaacaccat catgatatat gccggcagtg taaatagata cggaaaacct ttatcgcccg 3038461 catgacagat catatccttg gctgttgtat tgacttccaa acccgccgct ttcatagcgg 3038521 cggtcttacg tgaatcatga atattaaaga tatagaacat gaggaaaatc attgtcacga 3038581 tcaattgcag cgtgccttca atcagcataa acagcgagtg atcttcaccg ggaacacttc 3038641 ccaatgtcat caatccggtt agcgcctgta taccgaaaac gcataattca aaagcaaaca 3038701 agcctgtgat ggcaagaaat aagagcccct ttgacaactg ctgattcgca atctgcccaa 3038761 gtcctggaat gatcgataaa agccctgcct ttcgtttttg ctttgtaagt gtgtgatgtt 3038821 tattcatttt tccgccctct attcttccgg acgctatccc gccgttttat ttcacatact 3038881 tttctttaat attttccttt atgacgttta cagcatcatt cgctgatgtt tgtgtcgatt 3038941 tttttcctga agctgcatca aaaattaaac tttccgctcc tgtccatact tcagccattt 3039001 ccggaatatt tggagtcggc gttgctgttt catattgttt aatcacagct gacgtcagtt 3039061 cattcttttg ctcatcggct ttcttccttg cagccgtgtt ggccggaact tcgtttgtat 3039121 cctcataaaa agcgtaagca ttggcatcat ttgcagcata ctcaagccat ttttcagcca 3039181 gctcgggctc ttttgtatat ttcgaggcaa cccagccctt cccgccagca aaaggggcgt 3039241 attcttctcc atttggcaat gtcggaatgg gagccgctcc gtagttcaat ttagcctctt 3039301 tatagttggc agctgaccaa ggaccgccaa tgatcgcagc cgctttgcct tctaaaaaca 3039361 tctgctgaat aaagtcgtct gcgcttgaat tgtcttgcat tcctttcggc caatatgtct 3039421 caaaccattt ctccgcatat ttcaccgctt ctacagcccc tttattgttc aggccgatgt 3039481 ccccggaatc tgtgccgttt tttccaaaca catatccgcc gtatccagcc aataagccgt 3039541 acgacatata aaagtcagtc cattttgcta aaaatccggt tgattttcct ttttccgaag 3039601 caaacgcgaa tcgaggatct tccgttaact tttcaaggtc tttaaatgtt tttggcgctg 3039661 tttttaaaag atctttgttg taatacaaaa taagtgtctc aatgactagc ggcattccgt 3039721 acactttgcc gtcaactgtc acctgctgca tttctttatc accaaagctt tttgtgttag 3039781 atggcttaat atcaagtaaa tgtccttgtt gtcccaaacc gccgatccgg tcatatgcag 3039841 caagcataac atcaggcgca ttacccgccg ggccatcaag aggaagcgct tctaactgtt 3039901 cgaacatttg cttttcaaca atttttactg tgacatcatt ttctttttcg aactttgttt 3039961 ttatgctttc aatgtattct ttatacgttt cttcgacaga cacagtcagc acctttttgc 3040021 catcagagct tgctggattt tttgaacttg agcaggcggc aaggccgatt gccaggaatg 3040081 atgccgccaa tatggcgaac ccctttttta aaagaaccat ctcttttcct ccttctattt 3040141 acgaaactat aacaattgta ttgtcctata gaaagcggtt acaacaactt tcgatttgtt 3040201 accgataaca gaatgttata caggggcggc agcactcaaa atcaaaaatt ctcccggctg 3040261 aacggcaatg acatcgtgat gctgtagcgg ctgctctgtc catgcatcac agattttctt 3040321 attcctatca atattcaact ctcgtaaact gacgtgttga accacattcc cttgattaaa 3040381 gaaataaatc agtatttttt catcaagagt ccgcgaaaag ctaatgaaat catttttgtc 3040441 gtccagcaga ttccactcaa gatgtccttc agtcaataaa gtgttttcct gcttgcgtaa 3040501 agcaattaac cgtttcataa attgcagcat gtcttggttt tgcttctctt tttcccaaac 3040561 catacatttc cggcataatg gatcattttc gccgttcagc ccgatttccg ttccgtaata 3040621 aatgcatggt gagcctgtct gggcaaacat aaaggccagc aacgcgcgtg ctttcttctc 3040681 atcattgcgg catctggtca aaaggcgctt tgtatcatgg ctatccagta aattaaacat 3040741 cacctcattg gcctgcttca ttccattcat caaatgtgca ttgacacggt gagccatacg 3040801 tgaagctgag atcgtctggt cagcaaagta ttcaatcata ggctctgtaa aagggtaatt 3040861 catcgccgca tgaaattcat cccctctaag ccagggttcg gcagaatgcc agatctcacc 3040921 taaaatataa acatcaggct tttcagtaga tacagcctgc ctaaatgtct tccaaaaaac 3040981 gtgatccact tcatttgcga catccaaacg ccagccgtca atgtcaaatt cgcgaatcca 3041041 gtacaaagca atatcaagca aatatttctg cacctcggga ttagccgtgt ttagcttcgg 3041101 catatcagct gtaaaagcaa atctgtcata attgtcgtct gtgacgggaa aagagtgaat 3041161 atggaaccag tccttatagc gggattgatc tccgtttttg acgacatcct gccattgcgg 3041221 agacgcgctt cctatatggt taaaaaccgc atcaagcata attctcatcc cccgctgatg 3041281 cagctggctg accaatgtac gaaaaagctc aggatccccg aaatgcggat caatagaaaa 3041341 gtaatccagc gtgtcgtatt tatgattaga aggcgcggaa aagatcggtg tcagataaat 3041401 gccgttcacc cctaaatcct ctaaataatc aagcttgtca acaattcctt gtaaatcccc 3041461 tccaaaaaaa tcattgacgt ccgggtcctt gctcccccac ggcaatgcat tcttcggtga 3041521 caagtcttct cttccatttg caaaacgctc cggaaaaatt tgataccaaa ccgttgactt 3041581 gacccattca ggcgcttgaa atgtatcagc ctcgtgaaca aacggaaatt taaagtaata 3041641 atgaatcgtt tccagtgttt tttcgttata agggcataca cccgaacttc cgaaaaagat 3041701 gtcttcatga tcgtctgtta caacaaacgc atattgtaaa cgcctaaatg gcggcaccac 3041761 ttcagcaaac caatagtcat gcatttctgt agcagcaatt ttcctcatcg gctgctcgtt 3041821 tgccgaccat ttgccgtcgt tgtactcata gggatcaccc caaatgaatc gaatgtgatc 3041881 tgcatcacct tttttcgtcc gaatcttgat atgcacagtc cgcccatcat aagaataagc 3041941 atctgtgctg aatggctggt gatgaatcgc tgcatattcc atcatgtttc cccctttgat 3042001 ttccgtttta ttgaagccgg ctcatagttt gaaagtatca tgatgaaatt gtgggaacaa 3042061 tccttttcac cctgttaccg ataacagaat aaggcgctta cagcgttgat tctcgtacaa 3042121 ttaactctgg ttcaaaaaat agacttcctt gtgcagcgcc gtcttcattc atttttttca 3042181 gcaacatttt cgcacaggct tcccccattt caacaacagg ctgtctgacc gtagtcaagc 3042241 gcggcgagga gatgcgatca agaaacacac cgtcattccc ggtaaccgca acgtcttctg 3042301 gaattcgctt tccaagggat tgcgccgcac gaatgacgcc gagcgcgatt cgatcagatg 3042361 cgcagacaaa tgcggcctga ttgtccatgg atttcagcag ttctcttgca aggcattcac 3042421 ttttcttaga actgttgtcg atccgaaaca tattcgattt tttaaagctt ttattcatcg 3042481 cccgtatata cccctgttct cttgcacgtt cgaaaggctc atctaaatca atgccaaaaa 3042541 agacaacttc ccgctccccc agccccataa catggcgggt tgccataaaa gtgcctttct 3042601 cgttattcac atcgataaag tcatagccca tttcattttg tccaaatacg acgagcggct 3042661 tctcaaaagc ttttattaca ccttcaaaat cgttctttct caagccggtg gcaataatgc 3042721 cgtcacattg gccaatatta agagaatttc ttgtcacaag ctggagagca tagtgattgc 3042781 gatccagctc cctgctgatt cctgtcagca ggttcatgta atatggttct gtcgtatcca 3042841 tttcctcaag tatcaatagt ttcacaacct gtgttctgtt ttgcacgagc gctctcgccg 3042901 cataattagg gatgtaattc agctctttca tcgcagaatg aacaagcttt ttcaattcat 3042961 ccgtcaccgt ctcagggtga ttgatcactc gtgataccgt cattttcgaa acatttgctt 3043021 ttttcgccac atctgacaat gttgccattt tcatcccctc cttatctgtg cttattatcc 3043081 aaactagtga taaagtcctc tattactgct aaatatacga tgcaggccaa agagaaataa 3043141 aaaagagatt tcccttaagg aaacctcact ttgttaaaaa cactcgattt ttcatggatt 3043201 catacgctag gtggcagact cattctctcc acttccatca gaaaatctct tttttaaatt 3043261 tctgtccact ttttttctaa aatcggataa gaataatttt gcatttgctc aattaactca 3043321 tccggccgtg acgagctgtg aatcagtttt aggtgcgatt cgttagaaaa cccttcttga 3043381 atgctgtatt tcaccatttt catcattggt tcaaaatatc cgtttacatt gtacagtcca 3043441 attggctttt ggtggatgcc gatctgtgcc cagcacagca cttcaaataa ttcttcatat 3043501 gtaccgaagc cgcccggcat cgagataaag ccgtccgcca gctcgctcat tttagccttt 3043561 cgttcatgca tcccgtttac ttcaatcagc tcagtcagat tctgatggac aacctccccg 3043621 ctgaacaaac cgctcggcat gaccccgatt gcagttccgc cgttttccat aatcgcgtca 3043681 gcaatcgtgc ccatcaagcc tacgcgggag cccccataga caaggccgat tccctgctca 3043741 gccatataca cgccaagctc tgccgctttt cttttatacg cttcatttcc cccagggttt 3043801 gatcccgcaa atacacaaat ggttttcatc ttgtcatctc cgcatctata tatcgtgtta 3043861 aacattcaaa aacacactat atattgtccc atcttcatgt gataatatca atatgaaata 3043921 cataaagaat gcaggagtga tgaggttgca gctggctgat gcagaaaaat ggatgaaaga 3043981 gttttacgaa aaaagaggct ggacagaata cggacctttt attcgcgtcg gctttttaat 3044041 ggaggaagcc ggagaactgg cccgggctgt cagggcgtat gaaatcggca gagaccggcc 3044101 ggatgagaaa gaatcgtcac gcgctgagca aaaacaagaa ttgattgaag aaatgggaga 3044161 tgtcatcgga aatatcgcca ttcttgctga tatgtatggt gtctctttag aagacgtcat 3044221 gaaggcccac caagaaaaac tgacaaaacg atttgagcat gcataaaaaa gcggccgcga 3044281 tggccgcttt ttttaacctg tgatttcatc atggtgatca aagaaatgct gctttcctat 3044341 tttgtgaaaa aggcctgttt tatgcagtag ctccttcggc tgcgattgca atcctacaat 3044401 catcagcttt ccattgtggc gtttaattcg attcataatg ttcccaagca ccgcttcagc 3044461 tgacgtatcc atatagtgca ccttattcat gagcagaata agggttttcg gttttttctg 3044521 tacatgctcc agcaatgacg attcaaggga atcaattgat ccgaaaaaca gcggcccttc 3044581 tatggcatac atgctgacag atggatcttc tctcttcgcc agaacaggat gcgtttcctg 3044641 attgtggatg cgggtcgctt cgctcattct tctgataaag aacacgaatg caagcagcaa 3044701 tccggttgcc acaccgatga ttaagtcaaa cagaaccgta agggcgaagg tcgccgccaa 3044761 aataaaggaa tcagcatttt tcagtctcag catgtttgcg acttccttgc gctcactcat 3044821 attccatgcg accaccatga gaatcggtgc catactggcg agcggcacat gggacgcata 3044881 aggcgcaaat acaagcagga caaggagaac gactacgccg tgaacgacgc cggaaactgg 3044941 ggaaaccgct ccgtttttta tattggtcgc cgttctcgca atcgctcctg tagccgggat 3045001 tccgccaaac aggggcgctg ccatattcgc aatcccctgg ccgacaagct ccttgttgct 3045061 gtcatgcttt gagcccttca tgttatcagc gaccattgcg gacaaaatcg actcaagtcc 3045121 tccaagaagc gcgatgacaa gcgcagccgg aaacagcata accattttat ccaaagtaag 3045181 ctcaggaaac tgaaattccg gcaaatggcg ggggatttct ccataagttg acccgatcgt 3045241 tgccatgcgg tcagggaaaa agacaaccgc gaccactgtg gaaataagaa gcgccaacaa 3045301 agcgcccggc actttaggca tcaccttggc ggatacaagc aaaatgacga gcccgatcac 3045361 agctgtcaaa atggcataca cgttaaaggt gccgagctgc tgcacaattt caaacatgtt 3045421 gtgatgaaag ttctcatgtt tttcaacatt tctcaatccg agaaaattag cgatttgttc 3045481 cgtaaagatc agcacggcaa ttccggctgt aaaaccgacg ataacgggtt tgggcacgaa 3045541 tttcattatt tttccgagct taaacagccc aaacagtacc agcatcactc ctgccataaa 3045601 ccccgcaatc agcagatttt ccaagccgta ctgcatgata atgccgaata aaatcgggac 3045661 aaaggcgccc gtcggaccgc caatctgata ttttgatcct ccaaacaaag aaatacaaat 3045721 ccctgctata acaacagtgt atagcccata ttcaggctcg actcccgagg caatggcaaa 3045781 cgccattcct aaaggaattg ccacgacacc tactacgata cctgcaatca agtctttctg 3045841 aaatttctgc aaattgtatc ccttgaatct ccctgagaat cgcatatttt gttataacct 3045901 cccttatgag tgattgttta taagctcagt ttcataaccg ttaatgacca catcaagttt 3045961 tcctgtttca gggtgaatga caagcccgtg aaccggcact tttttcggaa gcagcggatg 3046021 gttcttaatc atgttcacac tgtgggaaac gctttcttcc acgctgtgaa aaccagtcag 3046081 ccacgttttc aaatcgagtc cggcactcgt cagcaaattc aggcagctat cctccacccc 3046141 gcgttccttt gctttctcaa gaatcgagga cgcattcagc cctgacattc cgcattcatg 3046201 atggccgaca atgcatacct cttcagcctg caattcataa atcgcgacca gtatgcttcg 3046261 catcacgctt ccaaatgggt gagaaacgat ggctcccgcg ttttttacaa ttttagcatc 3046321 accgttttta agccccattg cttgcggaag aagttctgta agccttgtat ccatacaggt 3046381 gacaatgacg agctttttcg aaggaaactt tgtcgttttg tacggttcat acttcttctc 3046441 actgacaaac cgctgattgt gttccaaaat tgatgttaaa gaaaccattt gattcatctc 3046501 ccatccatat gattttgcaa gccttcttac ccagcttaca gtaaggaatt atagcatagg 3046561 aataagccaa gaaaaggttt tcaaaaaaag acactataat tggactgtag aatcaaaaca 3046621 taaacattta tatctttcaa agataataaa atttatattt aatgcatcct ataatccggc 3046681 tgcagttcgt atatcgatga tttgtctgac aaaaaatatg ggtgaattct gataattaaa 3046741 aaactttttt aagcagattt agctgttcga tcttcatttt aagttcaaaa gaaccagaaa 3046801 ttaaaaaaac gcagctatat ttttaacatc tatttatttt cgatataatg aattagacaa 3046861 cagccataaa gggggagcct tgttgaaacc atttgtattt atcacaaaac cgattcctga 3046921 agagattgaa gcattcatcg gtgaacattg ccgttatgaa gtatggcagg aggatacgct 3046981 tccgagtgac gtgctatttg aaaaattaaa agaagcggag gggcttttaa catcagggac 3047041 gtccggaccg tcaatcaatc gtgagttgct ggaacacgcg cctaagctca aagtggtcag 3047101 caaccaatca gtaggctacg ataacttcga tatagaagca atgaaagaaa gaggagtcgt 3047161 cgggactcat acaccttata cactggatga cacagttgca gatctggctt tttcactgat 3047221 tctgtcttcc gccagacgtg ttgccgaact ggaccgtttt gtcagagcag gaaaatgggg 3047281 aaccgtggaa gaggaagcgc ttttcggaat tgatgttcat catcaaacgt taggcattat 3047341 cggcatgggc agaattggag aacaagcagc gagacgcgcc aaatttggtt ttgatatgga 3047401 agtgctttat cataaccgac atcgcaaaca agaaacagaa gacagcatcg gcgttaagta 3047461 tgcagagctt gatacattgc tggagcaatc tgattttatt cttctcatta cgccgctgac 3047521 tgatgaaacc tatcacatga taggagaacg cgaatttaag ttgatgaaga attcagcaat 3047581 tttcgtcaat atttcccggg gaaagacagt tgatgaaaaa gcactgattc gcgctcttca 3047641 ggaaggctgg atcaggggag ccggcttaga tgtatacgaa aaagagcctg tcacccaaga 3047701 taatccgctc ctgcagctgg ataatgtcac gctgcttcct catatcggtt cagcaacagc 3047761 taaagtgcgc ttcaacatgt gcaaacaggc cgccgaaaat atgctcgcag cgatccaagg 3047821 gcaaacaccg aaaaatctta caagagaatt tcaataaatc aaaaatccgg tctgataaca 3047881 gaccggattt catattacat acgctgaaga acagcacgct tataaatatg acgggtgacg 3047941 atataataaa gagcctggaa tacaaaataa atgaagatga caattacggc ctcaagaaat 3048001 aaattggaat tcagcatatt acttaacgct gcatacgcaa agcccgcgtg aatcgtacct 3048061 gcgataaatg ggatgaagaa taaaaatcct atttgctttc caaggatcga gtgaatctct 3048121 ttgtccgtaa cccctatcct ctttaacgct aacacctgca ctcccgtatc ttctatttcc 3048181 gtaaacatcc gcaaatacag catgcttcct tgcacgataa aaaacagcac gctgacaaac 3048241 agaccaataa acagcattaa tgcaactccc tgcttcacaa tttgataact aggagcacgt 3048301 gtttgaaaat cagatgtatg ttctttcggc accatgtttt caagcttttc agagacatcc 3048361 accgtctcct gccaatgctc aagctcataa cctaccattc tcatctgttc cttcagcggc 3048421 acatcctgtg acagactgtc aaagctcttt tcgctgacaa ccaataaacg gctgactcca 3048481 tcgacagaca tcaatatccc tttgttttgc tgctttttca tgacatagga aagggttttt 3048541 cctgacttca tatgaaatgc tgctgtttcc ccttctccaa atgtgtcttt caccatcatt 3048601 tgaaaagaaa cattaataaa tgcttcattt tcttgtaaat gaataactgg gaaccctttt 3048661 tcctttgcga cttgattata gactttttct gaaatcagca aagcttcagc ttccatcttc 3048721 ttatttccat acggcaagtc tgactgaaaa gtgacaggaa tccctgtggc atccacctta 3048781 tacgtgataa cagcatgagc ttttttcaat gtattctcag ccgtctcagg cttcatgacc 3048841 tgaaagcggg aagcatcctt ttccacccag gaaacagact gaggaatgct ttgctcctcc 3048901 tgcctttgta aatcggaata aaacatatag atgacacctg tagctgttag tatgaccgct 3048961 gtaatgacag aggttaaaaa cagcatgcgt gcatgatcct tcagcctgaa tatcatgttg 3049021 gaacgcacaa tgatatttgt gcctttgtag aagctgtgtt tctttcggta cagcatgcgg 3049081 aaaaatgcca cactgctttg ggtaaaaaag aaatacgtgc caattaacac taaaatcaaa 3049141 attggaaaaa cccgaaacat catgtcaatt gcattggctg ttgcagatag ataataaccg 3049201 ctgccaagac atagcaaaga caatacagtg agccatttcg aataaactgg caaacttttc 3049261 ggctttttgg ctgatttaat cagttcaatg atttccagct tccgaatccg tcccagtgat 3049321 aaaatgagca gcgtctgaaa caggatgaga aagccggcaa ttgtcatcac aaacgctttc 3049381 ggcacaatgg caaacgaaat cggcaccttc acgctgagca tccatgtcat gatcataaaa 3049441 aacagttttg aaaataacag gcctgctcca atgccggccg caatcgccgc aagagaaata 3049501 agtgactgct cataataaat catcttgcga agctgctgct ttgatgtgcc aaacagtgtc 3049561 agcagcccaa actctttctt tcttgcctgc aaaaacgctg aattggaata tgtgatgaaa 3049621 aatatacaaa acacaatgat gacgacaaga gctgcgctca agcatgtttt gacaaggctt 3049681 cctccatata tattgtcttc attgacatca ggatgaaaaa taaatgatgt gaagacaaaa 3049741 aacaccgaaa cggcaaacac acagcttaaa aagtaggcca cataccgttg cagattccca 3049801 agaatgtttt tacgggcgat agttctcaaa ttcatgaaaa tcgcctccca acacactcaa 3049861 ggtatccaat atactttgat aaaacacctg cctgtttgtt cctctgtgaa tctctgaaaa 3049921 gaaacgtccg tctttaataa aaacaatccg tttacagaaa cttgctgctg tggcatcatg 3049981 cgtaaccaac aaaatcgtcg cttccttttc ctcattcagc tgagccagtg tgttcatcac 3050041 ttgctttgcc gattttgagt cgaggtttcc tgtcggttca tcggcaagaa tgagcgccgg 3050101 attgtgaata atcgctctgg cacaagctgc ccgctgctgc tgtccgcccg acacctcata 3050161 tgtgcggtga tcgagaatat gctttatttg cagcgtatcc gccagttcat ccaatcgagc 3050221 ttccatttct ctcagcttta ccttatccaa tgcgagcggc aagagaatat tttcacgaat 3050281 cgtcagcgta tcaagcagat taaaatcctg aaagacgaag ccgagttctc ttctgcgaaa 3050341 caaagccagc tcttggtcct ttaacgtttt cggctgaatg ccgttgatca tcatctcgcc 3050401 ctgggtcggc ttatcaatgg tagccagcaa attcaaaagc gtggtttttc cgcttcccga 3050461 cggccccata atcccgacaa attctccttt tgacacactg agatcaaagg cgctgagcgc 3050521 ttggtatgat attgttcctt tatttgaata gtatgttttc gataggttcg ttgtttgcaa 3050581 cacgttcatg ttctgctcct cctttttctt tattataaaa aggaagtcag catcctccca 3050641 tcgaactttc ttgcaattcc gctccccaat cttacaatgc tgtcacattc acgagggtgt 3050701 cacttgaaaa cacgatggtc atcacagtgc cagccccttc ttttgattcc gcatacagct 3050761 tatggccgag acggctgcac acctgttttg ctaaataaag gcccattcca gttgcctctt 3050821 tcatggttcg tccgttttct ccggtaaaaa acgcgtcaaa aatccgcggc agatcctgcg 3050881 gcggtatgcc gattccttcg tcggcaaccg acaagcgcgt ctcatgtccc tgtgtttcaa 3050941 tccggattgt aatagggtct cccacacctt gctttgaata ttttaaggcg ttgaaaagga 3051001 tttgctcaac aacaaaggaa agccactttt gatcactgga aatctgaacg gcatttggcg 3051061 gcacatgtaa tgttggaaaa aggcgccgct tgataaactg acgtttttcc tgattgatca 3051121 gtgaacgaac catttctgcc aaatcaaagg tttgcggctt tacatcaaat gcaaattcct 3051181 ccagccgggc cgtttgcagc atcatatcaa gaccgtggcg aaatctctca ttctcatcct 3051241 ccagctcctc taaaaacgtc ggaaaagagg atgaggttcc gttttttcct tcctgaatca 3051301 ttaaggatat gacagatacc ggtgttttca tatggtggac ccattggttg gtgaaggtgt 3051361 aatgctgttt ttgctgattg atatattgtg agagcctgct ttcgtattgc tgcccgagtg 3051421 cgttgatcat cttcgtccaa agcgcttgct ctcctgttct tggctttctg gctttcaaag 3051481 actgtccgat gtcattcgaa gaagaggctt gttctgcaag ctttttaaca tatgtgagaa 3051541 aggaaaattg ccgaacataa tcagcagcaa aacctgcggc taaaagagta ccgggcaaaa 3051601 tccatatgta catcatattt tctttggaag gttctgcgcc gctctctaca atgcttaaat 3051661 acgcaatcag catggcggac cctatcccta ataatgaaaa tagaataatg gctaagcggt 3051721 cgatgagata agtctttaac attccgcttc atccttccga ttgacttgaa attgataacc 3051781 ttgtcctctg attgtggaaa tgcaatctgt cagtcctgca ttctccagtt ttctccgcag 3051841 ccgattgaca ttgaccgtta acgtattgtc atcgacaaaa tcaacgtcat cccataacgc 3051901 ctccaatagt tcatcacgag agacaatttt tttatgctcc ctcacaaaaa tcgagagaag 3051961 ctggaattct ttttgggaaa acaaaatccg gacgctgttc cattcggcct cattctgatc 3052021 aggataaatc gtcagcccgc caagctccac tattctagat tcctgcggca aagagggcga 3052081 atattcacca tatgtgcggc gcaggacgct tttgattttg gccatcacta cctctagatg 3052141 gaacggcttt gtgatataat catcgccgcc attttcaatc gccattacct gattcagctc 3052201 atcggtccgt gccgatataa agataatcgg cgcattggaa atggtacgga tttgcctgca 3052261 ccaataaaac ccgtcaaaaa aaggcaggtt gatatcaagc agcacaagat caggcttcat 3052321 ttctgcaaat tccaatttta tatcattcag ctgttcagca attttcactt catatccgta 3052381 tttttgaaga tgaccgccca gcaaagaagc aatccgctca tcatcttcca caagcaaaat 3052441 ccgatacacg ttgatccccc ttatatgtac atcacgatga tttttctaga agattccaaa 3052501 attattatag catgtgcgga atagtaaatc ggtctttttc tttttgttat gatagaatga 3052561 taaaggtaaa attttcataa taggcaggtg tcgtgatgaa gaaaatcatg ctgtttctgg 3052621 caatgacgtc aattctttca gcatgtcagc ccaactatac cgggaaatac atagaaattg 3052681 gggatacact aactgactat accaaagagt gctttaaaga gaatgaaatt ccttataaat 3052741 acgaaaaggg aaaactgtat atcccagaag acgcatttga tacagcaatc tacacttgtt 3052801 cataagaaaa agcttgcaga taacctgcaa gcttttcacg ttacaaaaaa tgagtattta 3052861 atttctcttc aaatcctgaa gggccgatgt cgcttttttg aatgttaccg ccgttttcat 3052921 aaatcgtaaa atggcgctct gacatgacca tccttccgct cggcgtcagc tttgaggcaa 3052981 gcagggattt gttaaaagga gatttttcat gagagtgaat gatgtccttc atgttatcta 3053041 aatcaccgag atcactctct tcaagggtaa aggcgtaccc aatttgccag ccttctcctt 3053101 tgtccatcag cagaacatag ctgccctttt ctgtctcttc ctttttgatt cggaatgacc 3053161 cgactggtga ctgtaccgtt tctccggaaa gcggtatcgg ctggagcgcc aggttgatgc 3053221 cgaagccgat atcaacgagg taatcgccgt tttccgcaga cagccataca gcagcatgcg 3053281 tcccttctag tgcccatccc tcttgatcgc ctgcataaac cgttcctcga atgagcttca 3053341 catgaaaccc ggcctcacgc aagacaaaat aaaggaaacc atttagatcg tagcataggc 3053401 cgccgtgctg atctttgagc agacgtcgcc atagctcttc ttttgtgatc ttataattct 3053461 cttttgcaag tacggcacgg ttttcgaatg gaaaacggta tgccattgct ttaagaaaaa 3053521 ggggaagatc gccgaagctg acatggtctt tctcccagcc gattttctga aagcagtctt 3053581 ttagaaagtc actcattttt atcacctaaa cttcttcttg aacgtaagca gccagcttct 3053641 ccagcgcctc ttgttcatct tctccctggg caatcaaggt aacctcagtg cctgtgctta 3053701 ccgcaaggct catcagcccc atgatgcttt tggcgtttac ttttttccca tccttctcaa 3053761 gaaacacatc tgacgtaaac cggtttgctt cttgtacaaa caaagcagca ggacgtgctt 3053821 gcagtcctgt ctttaatcga acttccactt tctgttgaac cataagatct ccccttttct 3053881 ttacggttat tttaaagtga cggtttgccc tgtccgcagc tgttctgcga tttcgtcaag 3053941 ttttctcagc ctgtgattga tccctgattt gctgattttc ccgcttgcta ccatttcccc 3054001 tagctctttc agcgtcactt cctgataatc aatccgcagc tgcgcaattt cccgaagttt 3054061 ttcaggcagc gcctccaggc cgattctttc atcgatgtat ttaatatttt ccacctgtct 3054121 cagcgatgcg ccgatcgttt tgtttaagtt ggctgtttca caattgacga ggcggttgac 3054181 cgaatttctc atgtcccgaa cgattctgac atcctcaaat cgcagaagcg aattgtgagc 3054241 gccaattacg ttcagaaact ctgtaatctt ttcagcctct tttaaatagg taatatagcc 3054301 ttttttccgt tcaagcgttt tgctgtttaa ctgaaactca tttaacaggt cacataatga 3054361 atcgttatgc tccttataaa gagagaagat ttctaaatga tacgaggagg tttccgggtt 3054421 attgaccgaa cctcctgcca aaaatgctcc tctcatataa gaacgcttgc agcatctctt 3054481 tttgaccagc tctttcgaaa tacttcgttc aaacacaaaa ttctccccga gtatttttaa 3054541 atcctctaag atcgcttttg cattttctga aaaacgcaca atatagacgt tattcttttt 3054601 cagccgcatt ttctttctga ccagcagctc gaccgacaca tcatattgtt ttttcagcaa 3054661 tgtatagatg cggcgggcaa tcgccgcgtt ttcggtttga acatcgagta cgagatggcg 3054721 gtttgtaaat gataaagctc cattcatccg aatgagtgca gacagctcgg cattaatgca 3054781 gcagtccttc acttccagat tcgttaattc tttttttgtt tctgatgcaa atgacatata 3054841 gccacctcat ttcaaggctt cattctttca gtaaatcaac aagaagagag gccactttat 3054901 gtgtatcgtg acgtattacg tcatttttat acgttacaat ttgatctctg atgacttcaa 3054961 gccccatcgc tttcagctct tcgatatcaa aatcaacagg acgcgccgat tccatttcgt 3055021 acttacgttt tatttcgtcg ggaatgtctt cactgttcac taatatcgta tcaataaaac 3055081 cacagcccat atgctgattg agcgctttca catgatcagc agcggtgtaa tggagcgttt 3055141 cgccgggctg agtcatcacg ttgcaaatgt atactttttt cgccggcgcc tttatcactt 3055201 cttccccgat ttttgggacg agcaaattgg gaagaatgct ggtatagagg cttcccgggc 3055261 cgataataat caaatccgct tccctgatta cgtctattgt ttccggcagc ggatcaatct 3055321 gttcaggcgt gagaaaaaca cgcttaatgc gctgtccgta ttctgggatc gttgactcgc 3055381 ctgagaccac gcggccatct tccatctcag catgcaaaac gacactggca ttggcagccg 3055441 gcaaaacctt tcctcttaca ttcagcacct tgctcatttc tgtgacagcg tgaaaaaaat 3055501 caccggttat atttgtcatc gctgccaaaa tcaaattccc gagagaatgg cctgttaagt 3055561 cattcccttt attgaagcgg tgctgaaaaa gatcttcaac aagcggctcc acatcggata 3055621 aagcggcaag cacatttctg atgtctccgg gaggcggaat tttcagttca ttccgcagac 3055681 ggccagagct ccccccatca tcggcaactg ttacaatggc cgtgatgtca acgggtttat 3055741 gctttaggcc ccgaagcaat acagaaagac ctgtaccgcc gccaaagatt gcgattttcg 3055801 gcttttgtcc catcttattt ccggcttctc ttttcaatgt cccggtgagt aacatgagta 3055861 tagtaatcct ttttgaaata atcagctaaa ttctcggcta atgtcacaga gcggtgctgg 3055921 ccccctgtgc agccgatcgc aatgacaacc tggctttttc cttctctttt gtaagatgga 3055981 agcataaagc tcagcagatc aattaatttc tcattgaact tttgcgtttc attccacttc 3056041 atgacgtaag aggaaacctc tttatccttg ccagtcagcg gccgcatgct ttcgatatag 3056101 tacggattcg gcaaaaatct gacatcaaag acgagatctg catcaattgg aataccgtat 3056161 ttaaaaccaa atgacatcac atttacggta aatgtctctc cttggtttgt cgcaaagtgc 3056221 ttcacgattt tttcacgcaa atcacgcggc ttcatgtcag acgtatcgta aatgatttga 3056281 gagcggcctt ttaattcctc aagcagctct cgttctagcg cgatgccttc aagcggcagg 3056341 ccagtcgctg ccagcggatg cgagcgtctc gtttctttat atcttgtgac gagaatggaa 3056401 tccttcgcgt ccaggaataa aattcgcggt gtgatccacg gattttcggc catttcatcc 3056461 agcgcttcaa tcagccggtc aaaaaattcg cggccgcgca aatccatcac gagcgcaact 3056521 ttgctcattt tcgaatttga ttccttcatc agctctaaaa acttcggaag caatgaaggc 3056581 ggaagattat cgacgcagaa atagccgaga tcttcaaagc tttggatcgc gacagttttc 3056641 cccgctcccg acattccagt tataatgaca agctgaatat catgtgattc actaacactc 3056701 atctttctcc cccctgactt gtctttctat ttgatgtgct gcgggtctaa acgataactg 3056761 agcagctcaa attccggtgt atacgtaaat gtgccgtgca gcagcccttg tcccttcatc 3056821 ataaaatcaa ggatatggcc gtctccaggg gccataggca ggttctgaat gtcattgaca 3056881 tcgtgccact gcagtttgcc ttcctctgat tctgatacat tttgtcctgt atatgaatca 3056941 gcgacaaacg taaacatcat ccactcggag acaatgtggt caccgtcttt aataataaag 3057001 gtaaaaacgc cttttaattg aggatttatg atatagatac cagtctcttc tctgtactct 3057061 ctgatgacgg agtctctgac tgattctccg ctctccatct tgcctcccgg cgcgacccac 3057121 catccgcgtc tcggcttttg aagcagaaga actttgtcat ccgtctgaag cacacaattt 3057181 gtcactcttt gcaagtacgt cacctaacct tcgtcctgtc atcgtctctt tattataccg 3057241 cttcaagatg cctcccacaa tgaagagaca ttgacaatct tttcttctat tttacagcat 3057301 attcattcct taattcagat gattttgctg taactggaat tctcttttat ttatggacaa 3057361 aaaaaggaca cggataactg gagaatccgt gccaaaaaag tgtattcatt ataaaaaggg 3057421 ggtcaattac tttattaatc ataaccgaaa agcattacac atgtgttaca gcggaattaa 3057481 aacccagtaa cgtaatgtga aactcgtatg acagcccttt ttattttaag gttttcagcg 3057541 tttcttggag ctcttcgaca taatgttgta cgctttgtgc cgcaatgctt ccgtctcctg 3057601 tagccgttac gatttggcgc agtgattttt cgcggatgtc tccggcagcg aaaatccctt 3057661 caaccttagt ttccatgcgg tcgtttgttt cgatatagcc ttcttcattc gtaatgccca 3057721 ggttttcaaa cggtttagac agaggaagca tgccgatgta aatgaatacg ccgtctgttt 3057781 tgaattcact ttcttcaccg gttaccgtat cgacaagcgt tacgttaccg actttgccgt 3057841 tttcctcatg aatttccttc acagttttgt tccataggaa gtcaactttt tcattatcaa 3057901 atgctctcgc ttgaagaata ctttgagcac ggagtttatc acgtctgtga acaatcgtta 3057961 cttttgaagc gaaacgagtc agatatacgc cttcttcaac cgcggaatct ccgccgccaa 3058021 caacgacaag ttctttgcct ttaaagaaag cgccgtcaca tactgcacaa taagatacac 3058081 cgcgtccgcc caattctttt tcgccaggca cgccgatttt tttatattcc gcacctgcag 3058141 caatgatgac agcacgggct ttatattcct ttgaaccagc tttgactact ttgtactctt 3058201 tgccgtcaat gacctcttta atatcgccat aagcgtattc agcgccgaat tttttcgcgt 3058261 gttcaaacat tttgttagaa agctcaggcc caaggatact ttcgaatcca ggatagtttt 3058321 ctacatcttc cgtattggcc atttgtccgc caggaattcc tctttcaatc attaatgtcg 3058381 ataaattcgc tcttgatgtg tatacagcgg ccgtcatccc agcagggccc gcgccgatta 3058441 taatcacgtc ataaattttt tcttctgaca cactattcac tccttaaacc atcttttcaa 3058501 gtttgggctc tttcttataa gataagaatc cccatcaaac gtattcctta cccatatcct 3058561 ataaaatctc atggtgatac gctatttttt tgctcaacac gattaaatgt attcgaaaag 3058621 ggtatatgtt aataaagaaa gagccttctg tttatagaag gcccttgtca tatttattat 3058681 tgaacaacac gtcttacaac acctttaaat gctgctttcc agtaaggatt gctcatagag 3058741 tcaacagata cgccatgaga tgtattgtcg tttaggaaag taccgtttcc taagtagatt 3058801 cctacgtgtc catttgtttt gtaagtgtca aagaacacaa ggtctccgcg tttcatttca 3058861 gacgcgctga cagcttgtcc tctgccaact aacgtatcag ttgttgttcc gcctacaggt 3058921 ccaaggttaa cacctgcaga agcgtatgcc cagcgtacga atgatgagca gtcaaaaata 3058981 cggttgttga tatcagactg agtgcgtccg ccgccaaact tgtacggaga ttgtcctaca 3059041 atgcttgaac caacgctgat cgcgccttca attccgccag agttgctgat aacagtgccg 3059101 cctgaattgc tgtttgagcc gctgctcttc ttagaagatg agccgtttga cgaactgttt 3059161 gatgaaccgt tagaagaatt gtctgaagaa ttgtctgaag aatcatcaga tgagcttgct 3059221 tttgatgatt cagttgtcgc cgtttgactg tcatctgttt gtgtttcatc agatgctttt 3059281 tgtgcttctt cctgcttttt gatcaaagca gccgctgctt cttgttcttt tttgatgcgt 3059341 gcttgttcag cttcagtatt tgctttttga tttgcaagtt cagacgcctc tgattttaat 3059401 tcagaaatcg ctttagccgt tttcttttgg cttgcttttg cttcgtcgaa aagcttgtct 3059461 ttttcattaa gctgtttatc aaggtctttt tgcattgttt ctaatttagc caaggcagct 3059521 tgaacttctt tcagcttgtc attcaaatcc gcttcagaat cttcgagctt cgctttatcc 3059581 tgctcttgct gtttgattaa atctttgtct gcgtccacaa tagatgaaac cgcagtcgca 3059641 cgagagataa agtcaccaaa gcttgttgat cctaaaagaa catctatgta tccttgagat 3059701 ccgccgcttt cctgtaaaga acgaacgcgt tttttcagga tttcattgcg tttttcgatg 3059761 cgtgcttcag tttctttaat ctcttttttc agttttttga tttcttcttt tgttttatcg 3059821 ttttcttctt ttttatcttc aatcttgttg cttgtatcaa gcgccttatc gttaatgtct 3059881 ttcagttctt tttcaatctt tgattgattt tcctgaagct cggttaattc tttttccttc 3059941 gcttcaatgc tggaagcaac ctcagattgc ttgctttcga ttttttgttt cttttcatct 3060001 aatgtttccg ccgatgcagt tttacttgta aatgggatca aaaaactgct tgtcccgatg 3060061 acggaagcca aaccaagtgt aattaaactc tttctcactt tttatatcct cccttttact 3060121 gtgaacctgt cctcatttgg aatcgtattt tgaacatcaa gtttcgttcc tcatactcta 3060181 cgaggaatga tggttgttta tggttaatta ttctgtgcat ctcttattct ggttgtatag 3060241 cgtttatttc acatcatatg taaaaaacac taattcctta tgtacgagaa tcattatacc 3060301 atcaagtttc gacaaattag cgataaattt tattacattt atgtttcaaa cagatgtcaa 3060361 gtcacacatc atttgtcatt tttcttaagc gtgtaaaaaa actgtcgata ttattttctt 3060421 aatataatct atctaacaaa aaaagagtcg attaaataaa tcaactcttt aaaatttact 3060481 attctagaat atcatcaata tatttcatat atttcgtcaa agttgccgga gagatgccga 3060541 atcgggccgc tgtgtctttt ttcgtgtctt gcttgccatg ggcttctttc caaatataac 3060601 agatggctgc tgcccagcct ttctcattct tcaacggagc agctgcacga atttgctgga 3060661 tgacatgaaa aacccagcag ctcatgactt ctgttttcat ctcttctttt tcagcttgct 3060721 ctaatagttt gaccgtttga taagcgaaaa gtgcatcctc tgaaacgtca gcagccgcag 3060781 aatctccatt cagaagcagc tttacaaaat gagtttcaaa aggagcggta attctctttg 3060841 agcgtatcac cgcttcaaga tgctctgttt ctccctttgt gctgctgata taataggctg 3060901 cgagtcgctg ctccacagat gaaggaagag cttccctccg ctcaatccaa ggcgccgggc 3060961 ggtcttcgcc gggatattgc gactcgactt ttctccagat cgtctcggca aagtcggtat 3061021 gtcccgtaaa ataagcagag caggaaagcc agtaaaagaa ggtgtcgtca ccctcaaagc 3061081 cggttttata taatgatttg agccatttat atccgatctc gtagcggccg acaagcgcca 3061141 aagtagcacc caatttataa cgctgctcca atagcatcgg atagacattg gagagctgat 3061201 cactcaattc cgccactttt tcgtcttctc tttcataata gtagaaaacg agaagattgc 3061261 ataaggcgtg aagatttcct tcattatgag aaagcacttc ataagcggtt tgcttcgctt 3061321 ttacaacgtt tcctgaatag aaataggcaa gcgcgagatt gttgtatgct gaccaaagct 3061381 ccggatattc agttgtgatt tcctcaagcg ccgcaaccgc ttcagcaagc tggccgcttt 3061441 ccagcaatga ctttgcccga tcctgtttca ccagcagttc atcctgatca tacaacgaat 3061501 cctcaatgcc gtcgtctcct aaatcgagca aatcaagcag actatcgttt tcttcggcga 3061561 attcaccatc cgggtccgca tcagaataag cggccgcttc tttataagct tcctggaaga 3061621 gccccagatg ggcaaagtta ttcgctttaa agtaatggca ctccggcatt tcggcctcca 3061681 gatttgccat gatatagtca agaagatcgt tcgactcttg atactggccc atttccgaat 3061741 aaatgaccgc aagctgtgaa agcatctctg aatcctccgg ctccaaatga accgcgcgct 3061801 gaatcagttt gcttgcccgt tttagattgc gctctttata cgctttcaag cctttatgaa 3061861 aaaaatattg tccatcttga agcagctgga caatttgtgc gtgattttta tgttcagaag 3061921 tgtgttttcc cacaactacc ctccgtttta tacaatatta ccgtcagtag tataccataa 3061981 atcgtaagcc cctcaatagt tcaaaaggaa ggattgggaa aatccctcct cttttttatt 3062041 ggctgattcg accaaaattt acccggcttt gttttctaag tccgcattca ttttcagctg 3062101 ctgttcagca aaatcccggt aaaggccatg ggaagccatt aactcatggt gtgttccacg 3062161 accggtaatt tccccttttt caacaaacaa aagctggtcc gcatctacaa cggtagatag 3062221 gcggtgagcg ataacaatcg ttgtgcggcc ctccatcagc acctccagcg cctgctgaac 3062281 tgatttttca gattggctgt cgagacttga ggtagcttca tcgagcataa gaatgcttgg 3062341 gttacggaga agcgctctcg caatcgcgat tctttgcctt tgtccgcctg acagcataat 3062401 gccgcgttcg cccacttctg tatcaaactg attcggcagc tcctttataa aattgagcgc 3062461 atatgccatc tccgcggctt tttcgatctc agcatccgtc acatctcgtt ctaacccgta 3062521 gcaaatattt tctctgattg tcccggacat taacgggctt tcctgtgata catacccgat 3062581 atgctccctc cacgattcaa gcgagtaagt atcgaccggc tcgtccccca gccgaatggt 3062641 ccctgcagtc ggagaataaa agcgttcaag cagcttaaac agcgtcgttt ttcccccgcc 3062701 gctcggaccg acgatcgctg tcactttccc tgcttcaatg acggcgctga cctcttttaa 3062761 gatcagctga tcaggcttat atccaaaaga cacgcgatca agctggatag gcagatgtgc 3062821 attttcaatt tgttttcctg tcactgtatc ttcctcttcc tctgccaaaa tctcaatcat 3062881 tcgttctgtt gcaccgattg atttttgcag ctgtgtgaaa aacgttgtaa tctggcccat 3062941 cggcataata atttgaaaca aatataaaat aaaagccacg agcgctccgg ctgtgagctc 3063001 gcctgatgag acctgcatgc cgccatatcc gatcactgcg acaagcgctg ccattaacac 3063061 gagtgaaata agcgggccga caagcgattg aaccttggct tcacgaacgc caagcttaaa 3063121 taatgaggaa atccccatct tcccgcgccc atattcgaca tcctccgcat ttgaagcctt 3063181 aacaagtctg atttccggga gaatttgatt aagcaggcct gtaaaacgag ccgtttcatc 3063241 ttgcgtttcc cgtgaaatgg agaacatttt ccgtccaatc ggcaccaaaa taagagcggc 3063301 cagcggaacg accactaaca caagcagtgt cagcttccag ttcataataa acaagattgt 3063361 caatgatcca atgacagaaa tgatgcctgt aataaatccg ctgatatggg ttgtaatcaa 3063421 ttctttgacc accatcgtat cgttcgttac acggctgact gtttctccgg aagcatttgt 3063481 atcgaaataa gagacaggca gcttaattaa tttcttccat aataactccc gcagcccgga 3063541 aatgattttt tgtccattat agttaagcgc ataggtggca taagcgctta aacccgcctg 3063601 aacgaaaaac accagcgcga tcaaaccgat ttgcgtgcct gacagatttg acatagaaaa 3063661 accatcgaca agctgcttcg ttaataatgg aatgagcagg ctgaccagcg tggttactac 3063721 actgagggca agcgcaaagg cgagctttcc ataagaagga ttggtccgtc ttactaaggc 3063781 aaaaaagggt ttcaatttac ttttagattt ttgtttcttg gttggcatat attttcctcc 3063841 tgtttcagcg ttcagaaagg tgaaaagtca tagcaaaagg atgattttta ctctttctca 3063901 atcatatcaa tggagaaaga ctttttcagt atatttttgc cgtgatcaaa ataaaaatct 3063961 cccactcatt gtttgaatag gagatttttg tgttagacat ctttcactgg cttctttttt 3064021 ctgtaagtca atgttacatc ctgctgtcgc aggtcttcta ttatcatttt gtaccgatca 3064081 acttttgcgg tatgttcttc ttttatcatc tgaagggcag cttttcgttt ttcgctatta 3064141 gactcaagct ctttttttat tttttttaca atcaaccctt tttgcccttt gatttcctct 3064201 tttaatgaag actcaaattt ctttgtcagg ctgagaaagt cgttgatcgg ttgattgagg 3064261 gtgcccgctt tccccttcat ttcatcttgg gtaagaaaca tataggtcgt tgatacaatt 3064321 tctgtttcac tttctgaaaa taaggaagtc actcttcata ttcctcctaa gactgaaaat 3064381 caaataactg agaaatcatt tcttcttttt caaacagctt ttcaatactc tcgcggatat 3064441 ttttgataaa atctcttttt tctgttgtct gtttttttaa ttcagcaaca attccatcat 3064501 ttgcaggaag cgcacctgtg tggaatgatt catgaactga gattttctcc aatttatcga 3064561 atgtgtggct gaaaccagct gcaagccgga attgaagatc gaaggcataa tgcgaagggt 3064621 tttcttccat atgatgaata gccgtgatga tcgcctgctt tttgtctatg aagtcttcat 3064681 cgatttcctg actgtaaacc ttctggtact tagaaatcgc atcttccata tcttcaacga 3064741 ttttcatacc gttttgatag attctgacag cggatgagag attgacttga atcgtttctc 3064801 ccgagccact cttccctgta aaataaatat cggagccttt atagctgaag cctttttcct 3064861 ttgacaaggc gttgagcatt tgaacgatgc tgtggccgtc gacgataagt tttagtgcgt 3064921 cttttgtttc tgtgtcgagt gttttcaatg aggacagaat tgattttaca tagtccacta 3064981 tttcaccaac gtcttttaaa gcttgcataa attggccatg ttttagatgg tctatgaaat 3065041 gttcgtaccg tgactctatg cctcgcatac tcgcattaat attcgttaat tcttttttga 3065101 tgactttctt ttgcgtttca tcaatataac cattttcagc taactgatct acgaccggtc 3065161 cgctgtttct caacaaggta tgaagaaaac ctaaaaacga cggcagttcc tcttttattc 3065221 ggccatacat ttgcttaaca tcatcaaaat gctcatatag gacacttact ttctttaaag 3065281 cgccgtctgt gtttttcact ttttcaatca ggtctatgtc tatcccgctg gctgccttta 3065341 taaaaccgtt caagccgtct ttttcatagt catccttata tttttgaagg aatttttgaa 3065401 ttgacctcac atcttcgtca ggaaccccat ccataatgtt tcggatgcct tttacacttg 3065461 tatttgtatc tgccatcttc acatcaccga atgtaataaa atcggccttg ccgctgactc 3065521 catacagcgg gtcatctttt gagatgcgct gagtgatgtt tgttgttacg cctttgtctt 3065581 cataatattt ttggatttct ttttttaact tttctggcgg gatggaatct atatcttcat 3065641 atttataact aaatttccta ataacatatc tatataaact ttcatcagtt tcaagtaatt 3065701 gatcaatatt gacttgagct ccatttaccc cataaacttc atcatattct ccatcaatca 3065761 attgcaccat aacttggtta ttatttgcaa gtgaatgtcc taaggcgaat gtttttaaat 3065821 cctcagagtt acctgctgct ttctttgctt tgttagtaaa ctcctttgta gcctcatact 3065881 gactatgatc aattcctaaa aaaagaccaa aaaagttata tgaccaatcc ttattatcgg 3065941 cactaccttc tgaaataatc tgaagctgat caatatgttt tttctcatct attatatgga 3066001 ttgccgttcc atcgtaacct gattctctgg tcgaactttg tatacttgta ttctgattta 3066061 caagttcatt ggaggtgtaa atttcaattt tcatattctc aggaagatcg tggtgggttt 3066121 cctctttata aattctgcgt atatctgctt cgaaatcctt cttagctttc ttaacttcac 3066181 tcgcaatagt tgaggcaaac ttttgtttat agtcatattc taaatcaatt aaccttaact 3066241 ttacgttctc attctcaaat acatttttat ttcccatctt atttctcctt tttatctatt 3066301 aaaaaggtga tagaattaat taatttctca actttatttt tagccttttc ttcatctaag 3066361 gagcatggtt gattttcatt tttgcatcca agggtaaagg cgtattctac tcctaggtta 3066421 tcttcctctg tagacttaac atatccaaaa taactgtatg aataattata ttttctatca 3066481 atatcgtcaa agatgtcttt tttcttggca gtgtaaatat ccgttttctt tttgctgctt 3066541 tttttgtatt cgcctttata atcatttttt ccactaacaa tatctagcat tgtcttaggt 3066601 tcattcgcaa aactttcttc tttgtaatat gttacatggc catcaaacat tacattggtg 3066661 tctttatcat aactattaaa tccaatactt tctttgtttt tcccggttaa cgatgatctt 3066721 cttgatagat actttccatc ctccggaaac aacatcctaa accctttcag cttagattcc 3066781 agcaaataat atcctggttc ctcttctttt gttgacacca tgtactctct cgttttctcg 3066841 tcctgaaacg caggtacttg aggcagatcc ttgggatcca tgtcttttgg ttttaccgct 3066901 tctgttttat tgtcatttgt gctgttttta tcattgtcat tcatactgca tcctcctgtc 3066961 agggcaagta ataagctgaa gcaaataaag atgatctttt tcattacgaa cctccacggg 3067021 ttttgtgaga atagtattct atttttatat caaaaataat tctattgacc tggttaagag 3067081 atgattattt catccttttt catgttacat catggcggaa tttggataaa taggaaatga 3067141 gactcggttt tgatctcctt ttattaacta atcatatata acacccaata taaatctaaa 3067201 tacctattac ttttttcaca aaacaaaaag agccgtatca tccggctctt tactcttcaa 3067261 tctcagaatg gcgttttttc aatacgtcaa gcacatcatc cagcggcagg gattgttctc 3067321 tgagcaggac aagcaggtga tacagcaggt ctgccgcttc ccatttgagt tcctcatgat 3067381 cccggttttt cgcggcgatg atgacttcgg atgcttcttc tccgactttt ttcaaaatct 3067441 tatcgacgcc ttcacggaag aggtacgtgg tgtaagctcc ttcaggcatt tccgcttggc 3067501 gttccgcgat cacccgctcc agttcgttca tgatgccgaa tcggtccgcg gcctgttctt 3067561 ctgtttgttc ctttgtaaaa cagctgtagc tgccagtgtg gcatgccggg cctgacggtt 3067621 ctacgagtac gagcagcgcg tcttgatcgc agtcataccg gatacctttg acggcttgcg 3067681 tgttccctga ggtttctcct ttatgccata acgcttggcg tgagcggctg taaaaccatg 3067741 tttccttcgt ttccagcgtt ttttcgtacg attccttgtt catatacgca agtgtcagca 3067801 cttctttgct tgccgcatcc tgcacgatag caggaattaa tccgtcctcg ttaaaacgca 3067861 gttcatctgc ctgtttcatc tcacattcac cccgtactct ttcaagtatg atttcacttc 3067921 tttaatcgat gtttctttat aatgaaaaat tgaggcggcc agcgcggcgt cggcttctcc 3067981 ttttgtaaaa gcctcaagca tatgctgtgc gtttcccgcg cctcccgaag cgataacagg 3068041 gacggggaca gcttcggaaa caagctttgt cagcgtgtgg tcgaaacctt ttttctcacc 3068101 gtcggagtcc atgcttgtca gcaatatttc tcctgccccg cgtttgacgc cttcttttgc 3068161 ccacgcggtg acctcccaat ctgttttctt tctgccgccg tgcgtgtaga ccttatatgt 3068221 gtcagattct ttgtcatact tggcatcaat ggcaagtacg atgcattgag aaccgaaaaa 3068281 ctcggctcct tctgtaatca gctcagggcg gagaacagct gccgtgttca ccgacacttt 3068341 gtccgctccg gcacgcagta tcgttttcat atcgctgagc tgattgatgc cgccgccgac 3068401 tgtaaacgga atggcaagct tcgcggcaac ctgctccaca acgtcaacca tcgtctttcg 3068461 tccttcgtgc gaggcggaga tatcaagaaa aacaagttca tccgcacctt cccggtcgta 3068521 cacttcggcg agttcaactg ggtcaccggc atccttcaat tcgagaaatt gaattccttt 3068581 gacaacgcgt ccttctttga catcaaggca tgggataatc cgttttgtga tcatttgcgc 3068641 ttcacccttt caagcgcctc actcagcgta aactgattgg tatacagcgc ttttccgatg 3068701 atcgctccag agacgccgtc cgcctcattg cgggcgagag cttcgagatc cgcgacggag 3068761 ctgactccgc cggaagcgat caccgatttc cccgtttcct tagcaagctc gaccgtgctt 3068821 ttaacattgg ggcctgacag cattccatct gtcgcgatgt cagtaaaaat aaagacttcc 3068881 gcaccttcat tggctagctc tttgcccagt tcagttgcct taagggttga tgtttcaagc 3068941 catccctctg ttgaaacaaa accgtttctc gcatccagtc cgattgcaat tttctcgcca 3069001 tattgtttca gcattttttt gacaaacgga gggttagaaa ctgctgagct tcccaggatc 3069061 acccgctcga ctcctgctga taaatattca tagacgtcat tttcagaacg gatcccaccg 3069121 ccgatttcga ctttcaggtt cagcttttgc gcaatctcaa tcacatggcg gtcattcact 3069181 cttttccctt ctttggcccc gtcgagatca acgagatgga tccattcggc accctctttc 3069241 tcaaataact cagccatgtc gtacggtgaa tcgccatata tcgtttcctt attataatcc 3069301 ccttgaacaa ggcgaacaca tttgccgttt ctcatatcaa ttgccggata taatgtaaaa 3069361 gcactcattt tttcaccttc tgttctgctg ccattttcgt aaattgggtt aaaatagaca 3069421 ttccgaccgt gctgcttttt tccggatgaa attgggcgcc gaagacgttt ctttttccga 3069481 ctacagcagg cactcgtaca ccataatcgg cgcttgccag aagcgcgttc tcctccatcc 3069541 cgtcaatgta ataggaatga acgaagtaag cgtagccttg ttctgtttta gtcagcagcg 3069601 gagattcatt atgaaaagaa agacgattcc agcccatatg cggaaccttc agcttgtttc 3069661 ctttttcatc ttctgctttc agcctgactg cttttccttt taacagcccg agtcctgaag 3069721 cggtgccgtt ttcttcgctt tcttcaaata aaagctgcat gccgaggcag atcccgagaa 3069781 gcagccttcc ctctgagacc atatcgtgaa tcaattgatc aagcttcgtg tagcccaaat 3069841 tgtccatcgc gtctccaaat gaaccgactc ccggcaaaat gaaagcatca gcttctttca 3069901 gctcctccgg cttttcagaa acaaaatacg gcacgccgac acgttcaagc gcctttgaga 3069961 cactgtataa attccccatt ccgtaatcta tcacgccgat catttacagc atccctttcg 3070021 ttgacggtat tcctttaact cgcggatcga tcgttgtcgc ttcatcaagc gcacgtccca 3070081 gtgctttaaa aacggcttca atcatgtggt gggtatttgt tccataatga acgatgacgt 3070141 gcaggttcat tcgagcttcg agcgccagct tccacaaaaa ttcatgtaca agctccgtat 3070201 cgaaagttcc gactttagca gccgggaaat cagcgcgcat ttctaagtgc ggccggttgc 3070261 ttaaatcaat cacaacttga gcaagtgcct catccatcgg cacaaacgcc gatccgtagc 3070321 gtttgattcc ttttttatcg cccaacgctt cgagcagcgc ctgccctaag cagatgccga 3070381 tatcttcagt cgtgtggtga tcatctatat caacatcgcc ttttgcgtta atggaaagat 3070441 caaattggcc gtgtttcgtg aataaatcca acatatgtgt cataaacggc acatctgttt 3070501 taatatccgc ttgtcctccg ccgtctattg taaatgccag ctcaatatct gtttcgtttg 3070561 ttttcctgac gcgttccgct tttctcattt agaaatcctc cgttctctcg cttcaattga 3070621 tctggcatgg gcttctaacc cttccagtct ggcaaaagcc gcgatgcttt cggcatgttc 3070681 ttcaaaggct gattgactgt aagaaataat gctcgatttc ttttgaaaat cagttacgtt 3070741 taatggactt gaaaatctgg ctgttccgtt tgtcggaagc acatggttcg gtccggcaaa 3070801 ataatcaccg acaggctcag ggctgtatct gcctaagaaa attgcacccg catgtttgat 3070861 actgccaagc aaagcttccg gagactgtgt tatgatttct aaatgctctg gcgcgagtgt 3070921 attgacagtc tcaatcgctt ctaccattgt ttccgccaca tatatacaac cgtaatctct 3070981 cactgaagct tccgctattt ctcttcgcgg caaggtttcc agctgcttat tcacctcggc 3071041 tgaaaccgtc tcggccagcg ccatggaatc tgtgacaaac acacatgagc taagcttatc 3071101 gtgttccgcc tgtgacagca gatcggctgc aatttcgctc ggaatcgctg tttcatcagc 3071161 cagcacgacg atttcactcg gtccggcaat catatcgata tcgacatcgc cgaacacttc 3071221 tcgtttggca agcgcgacat aaatgttgcc cggacccgtg attttatcca ccggctcaat 3071281 ggtttctgtt ccgtatgcta acgccgcaat cgcctgagcg ccgcccattt tgtaaatgtc 3071341 ttttatgccc agctcggctg cagcaaccaa aactccagga gacagcagac cgtcttttcc 3071401 cggaggcgtg acgagaacga ttctttcaac gcccgctacg agcgccggaa tcacattcat 3071461 caaaacagat gaaggatatg cggccgttcc ccccggcaca tatacaccgg cggaatccag 3071521 cgccgtcact ttctgcccca gcattgtgcc gtcctttctg tgataaaacc aggaggattg 3071581 cagctgtctt tcgtgatatt ccctaatatt ttcgattgcc tgcctaatca cctgaagaag 3071641 acgtgaatcc agtgaggtgt atgcctcctc aaattcttct tttgtgacca gcgggctgtc 3071701 tatttcgatg cagtcaaatt tcgccgtgta gctgcgaacc gcctgatcac cgtttgcttt 3071761 aacatcttca ataatggacc ggaccgtctt tctttgctct tccgttccgg catcgatgga 3071821 acgcttgaga gaaagccgtt ccgctccgct gatggttttg atcttcattt tgccgtctct 3071881 ccttccacaa cgagagatag gcgggatgcc atttcgtcaa tcacatcgtc tttcatgcga 3071941 tagcttaccg ggttgacaat aaagcgagag gtaatgtcac aaatgtgctc cgtttcaaca 3072001 agcccatttt ctttcagcgt ctgtcctgtg gaaacaatgt ccactatccg atctgcaagc 3072061 ccaatgagcg gagccagttc aattgaaccg ttgagcttaa taatctcgac ttgttctccc 3072121 tgctctctga aataactgga agccacattc ggatactttg tcgcgattct tggcgctact 3072181 ccgctccagt ctgtattcgg aagtccggcg acagctaagt ggcatttgct gatgtttaaa 3072241 tccagtacct catacacatc gcgttcctcc tccagcatga catccttgcc cgcaattccg 3072301 acgtctgcca cgccatgctc cacatacgtg gttacgtcca tcggcttcgc taatataaac 3072361 cgaagatttt cctccggcac atcgatgatc agttttctcg aatcttcaaa ctcctcaggg 3072421 agcctgtagc ctgcctgcct cagcagccct gccgcttctt caaatatccg gccctttggc 3072481 atcgccattg tgagtaactt acccattttg ctcttccttt ctggcaccga taaaataagt 3072541 gacgtttgca aaagattttg tcatctggtc gatattttct attcccgata aatcttgaag 3072601 aaccactttg ttccctttca tgcgttcttc attcgcataa gcgatggctt gcgcccgctg 3072661 ctctttgctg aaaataacag cgtctatttc acaaggttcg tccttcatat gaagggcttc 3072721 aatcagccgg tcgatccgaa gcccgaagcc tgttgccggt gcaggtgaat caaaatggcc 3072781 cagcagcttg ttgtaacggc cgccgcttcc aatgacaaaa ccgacattct cggcgtacac 3072841 ttcaaataaa atccctgtgt aatagctcat gtggctgacc atattcagat ccaggcggac 3072901 attttccgta catccgtaat cctcaagaat gtcccacagc gccttcagct catcaaccac 3072961 gctttttcct tgcgcagaat cgacgatttc ctcggcacgt ccgcatactt ctataccgcc 3073021 ccgcagttca aggagctcaa gcagcctgct tttatcaatg gaggaaagcg ggagagactt 3073081 gacatgctct ctgtagccga cgtagttctt ttcatataag aacctccgca gcacatcagc 3073141 tcgttcaacg tttccgagca cctcaacaaa caaagcatcc gcaatgccgg catggccaat 3073201 tgcaatttta aaggatgcca gcccagcgtt ttttaatgcc ccgacgacta aagcaatgac 3073261 ctccgcatcc gcgctcgtcg tgccgtcacc gattaactcc actccgacct gctcgaactc 3073321 agccggacgt ccgccttcac gctcctgagc cctgaataca tttgccgcat agccgactct 3073381 tagcggatga ccgtgtttca gaagcttcga tgccgccacc cttgcaatcg gccccgtcat 3073441 atccgggcga agcaccaatg tcttgccgtc ctgatcaagt agcttaaaca gctgctgctc 3073501 ttcaattgct gactggacgc caacggtatc gtaaaactcc agtgtcggcg tttccataaa 3073561 ttgatatccc catttatcaa tcaaatcggt taacgatcgt ctcacctttt ttttcgtttc 3073621 gtataaaccg ggcagtgtat ctctcatgcc gtgcggtttt tcaaacataa acatcaaccc 3073681 gagcacctcc gctgttatct tatgaaggaa aattccgaat cctttagttc gctaatatga 3073741 taatatgtta gcagatgaaa gaatgaaaat caacgcttaa cttcagtaag gatattttta 3073801 gttcaaatat ccttctcctc attatgaaaa aatcatgaat aatgtattaa aggtacgtaa 3073861 tatctcaaat tctttatgtt tggcatgcta taatacaaat caaatagaga acaaggagat 3073921 aaagatgaaa acactgcgaa ctctatgtgt cctgatgatt ctttcaggcg ttattttttt 3073981 cggacttaaa atagatgcaa aagatataga tattcctttt ttgaacagcc ttaaaaaagt 3074041 ggtttctgat agcgatacag actcagctgc gaatagcaaa aaggagctga agggaagcgc 3074101 aaaaccgctg gatgtcatcc tttacaatca aatggacgca ccccggctct ataacggctg 3074161 tgaagtaaca agccttgcga tggtgctgaa ttatgcggga tacgacgtga caaaaaatac 3074221 cctggcaaat caggttgcca cagtgccttt gacatacagc agcggattaa agggtgatcc 3074281 gaatgacgga tttgtcgggg atatggcgaa tggccctggt ctcggtgtct accatcgacc 3074341 gatctatcag ctggcgaaaa cctatgcggg agacaaagtg tctgatctga ctggaaaaag 3074401 tatttccgct gtttatcagc agcttgaaaa aggcaatcca gtttgggtta ttacgacagc 3074461 caactttacg ccagttgaca acatgcagac atggaaaacg ccaaacggaa cgatagaaat 3074521 tacgtacagc gaacacagcg tcgccgttac gggatatgat gataaatatg tgtatctcaa 3074581 tgatccgtat ggctataaaa acagaaaaac cgatagaaca agctttgaaa aagcgtggaa 3074641 acaaatgggc agccaggccg tggttattca aaagtaaaca cctgaagcct cactatgctc 3074701 tattctgagc aaatacgaca atattcatgc tttttgtatc aatcggtaag atcgattcat 3074761 tttccatttt tcacccaaaa ttgtctttac tttcaggctg tctgttttta tgattaaagc 3074821 agattcagcc ttgccccgat ctatgcgaga gaagccggtg caagtcgctg acgcttctct 3074881 tgcaaaaaat gaaagatatc cggggaggat ttatcattga aaaaaatcgt gtctatccta 3074941 tttatgttcg gtttggttat gggtttcagc cagtttcagc catcaaccgt ttttgcagct 3075001 gacaaagtgg tgcacgaaac aattatcgta ccaaaaaata caacatatga cgggaaagga 3075061 cagcggtttg tggcagggaa agaattaggt gacggaagcc agtcagaaaa ccaagaccct 3075121 gtttttcgtg tggaggatgg agcaaccctg aaaaatgtgg tgcttggtgc acctgcagct 3075181 gatggcgtgc acacttatgg aaacgttaac attcagaatg tgaaatggga agatgttggt 3075241 gaggatgcgt taacggtgaa gaaggaagga aaagtgacga tcgacggcgg ttctgctcaa 3075301 aaagcgtcag ataagatatt ccaaatcaat aaagccagta ccttcacagt gaaaaatttc 3075361 acggcggata atggcgggaa gttcattaga cagcttggtg gttcaacctt ccacgttgat 3075421 gtgatcatcg acaagtgcac catcacaaac atgaaggaag cgatattccg gacggacagc 3075481 aaaacaagca cggtcagaat gacaaataca cgctactcta atgtcggtca aaaatggatt 3075541 ggtgttcagc atatttacga aaacaacaac actcaatttt aacaaaaaaa gtccgctgat 3075601 gttattcagc ggactttttc aatctttctt gcatttcttc cttcgtatag atgatcctca 3075661 tcggatttcc gccgacaaat gccccgtcag gcacatcctt atggacaagc gttccggcgg 3075721 acacaactgc gccatctcct attttcaccc cgggcagaat ggtcgtgttg gcaccaatca 3075781 tcacttcgtc cccgatcaga actttgccga tccggtattc gtgaatcaaa tactcatggg 3075841 ccagaatggt cgtattgtac ccgatgattg tatttgttcc gactgagatc ttttccggaa 3075901 acatgatatc tggcatcacc atgagggcaa aggatgtctg ttttccaacc ttcatccgca 3075961 gaaatgtgcg gtacagccag tttttcatcc ctataaacgg cgtatatctc gcaatttgaa 3076021 tgacaatgaa atttttgacg acctttaaaa aaggtaccgt ttgatagaca tgccacagtg 3076081 agttggcccc cgagaccgga tgacgatctg tttttctcac agattacttc actccaacga 3076141 tttgtaatag atcactcatt ttctcaagca taaaatccgg ctcatgcttc gccagcattt 3076201 ccggcccttt aatcgtccat gcgactcctg ccgtttttgt accggcgttt ttccctgcca 3076261 gcacatcatg gtaattatca ccgaccataa tggcttccgc cggctcgctt cctagctgtt 3076321 tcagcgctaa cagcacaggc tcgggatcag gctttgcatt cgtcacatca tcaagggtga 3076381 caactgtttc aaagaattcg ccgattcccg tgagcttgag gcccatattg acagtatctc 3076441 ttaattttgt tgtcacaatt cctaatgtaa agccggcttt ttttaatgca tccagggtct 3076501 catataccgt ttcatattca gtgacgagtg aatcatgcat gtcatgattg tacgctctgt 3076561 acatagcgat catatcctcg catttatcag ggtccatcga agagaacgta tcaaaaagag 3076621 acggcccgat aaatgcaagg acatcttctc gtttatactt gctcggataa taatgctcca 3076681 gtgtatgcaa aaaggacgcg ataattaatt cattcgtatt aataagcgtt ccgtctaaat 3076741 caaacagaat cgtcgttact tgtttgtcac tcatattgct tcctttccaa ccgctgaggg 3076801 tttccatttt ttccacgtgt gcgcaatagc cattgtcagc agaactgctg tggtgacacg 3076861 aatcaaaaga agcggccaga ccggtatgcc aagcggaata aagacaagtg tatcttccac 3076921 gaccgcgtgg caggcaacga gaaatataaa tgccaatgtc atgtcccgct tgctcacgcc 3076981 gtcatcctcg acagctttga tcatgacacc cgctccgtag gccagaccaa tcgtcagtcc 3077041 cgtcaccatc gtcatagacg tatttttatt catgccaagc agctgcgtaa acggcgacag 3077101 ccacctggaa aaccgataaa gccagcctaa atctcttaaa aactggatga taatcatcag 3077161 cgggatcact attgccgcca gctgcaaaac accaagtccg gctttcgtta atgcttctgc 3077221 caacattcct agccagctgt ctggcgccgc gctcttcgca gcgataaaac cgtactgcgc 3077281 cgtttccttt ccgccatgcc aaatgaggtt gatgacgatg gctgacacag cggccaaacc 3077341 gatgcgcacg gccaatatga cgccaattct gataccaacc tttgcggcaa ctgtcgattc 3077401 gataatcaag ttatgacaga aagaaagcat aacagctaaa ataaagactt ctttcacaga 3077461 taaatccaat gttaaaatcc cggcaattcc cgcatacaga ttcagcatat ttcccagtac 3077521 aagcggaatg gccgcttcac cagaaagccc gaagagaccc attaccggtg tgatcagccg 3077581 tacaagccaa tccatgacag gggtatgctg gagcaaagtg accaatagcg ttaccgggaa 3077641 aatcacttta cccagcgtcc atgttgtttg aaaacctgct gcaagaccgg ccagaaagat 3077701 cttcttcatc cctcatcccc ctttgttgac gtctactccg cgtaccgctc cttcgagtat 3077761 cccttgacgc gtctgaagat gatggctgcc acagccaaaa caatcaatac gattgaaatc 3077821 acctgagcga tgcgaagtga atcagtcagc attaagctgt cagtccgcat tccttcaata 3077881 aagtatcttc cgattgaata ccaaatgata tagatcaaga acatctcgcc tctacgcaaa 3077941 ttcgctctgc gcagcagcag taaaacaatg acgccgacaa agctccatag tgattcatat 3078001 aaaaaagtag gatgataata ttgcccattg atatacattt gattgatgat aaattcaggc 3078061 aggtgcaggt tttctaaaaa ggctctgctg acagcctcgc cgtgcgcttc ctgattcatg 3078121 aagttccccc agcggccgat cgcctggccg agcaaaatgc tgggcgcggc aatatccgca 3078181 agcttccaga acgaaaggtt tttcactctc gaaaacacat aacccgttaa aatggcgccg 3078241 attaatccgc catgaatggc aatgccgccc ttccaaatct taatgatttc tcccggatgt 3078301 gccgcataat agtcccattc aaaggcaaca taataaattc gtgcgcaaat aatcgcaatt 3078361 ggaatggcaa acaggacaag atcaataaac gtatctttct gcagcccccg tttttcactt 3078421 tccctcatcg ctatccacag cccgagcaaa gcgccgagac cgataatgat tccgtaccag 3078481 tggacggcta acggccccag ctgaaatgct atcggattga gtggttctat cgcttcattc 3078541 atttaacgcc aactcctatt cttcttgttc accgtcttca atgacgtccg ccagcttgtt 3078601 ggtaaattgt tcagcggcat tcagccccat ccgcttcaat ctgaagttca ttgctgccac 3078661 ttcgatgatg actgcaagat ttcggcctgg gcggacggga atcgtcagtt ttgtaatttc 3078721 tgtatcaatg attttcatgg tctcttcctc aagtccgagc cggtcgtatt gcttgccctg 3078781 ctcccagagt tcaagattca tgacaatcgt gattcgttta ttgcttctga ccgcgccagc 3078841 gccaaatagc gtcatcacat tgataatgcc aaggcccctg atctcaagaa ggtgctcaat 3078901 taattccgga gcgtttccca caagagtatc ctgatcctcc tgccgtattt caacgcaatc 3078961 atcggcaaca aggcgatgcc ctcttttcac aagctctagc gctgtttcgc tttttccgac 3079021 gccgcttttt cctgtgatca gcacgccgac accatatata tcgacaagaa cgccatgaat 3079081 tgctgtggta ggcgccagcc tgctctcaag gaagttggtt aaacggcttg acagtcttgt 3079141 cgttttcagc ggcgatctga ggacaggcac cccatttttc tcggaggcgt caatcagctc 3079201 ctgcgggatg ggcatatctc tagaaagaat aatagctggt gttacatcag tgcacagaga 3079261 atccattcgc tgctttttct cctcttcagg aagctgttca aagaaagaaa gctctgtttt 3079321 tccgagaagc tgcacgcgct ccctcgggta atatgtaaaa tatccggcaa tttcaatacc 3079381 tggtcttgat aggtcactca ttgtaatcgg gcggttaatt ccttcttctc cgctgattaa 3079441 ttccaaattg aactgttcca ttacgtcttt tgtgcgaacc tttgccacga tatgttcctc 3079501 ctgttccggg ctgccccgag cttgctcaca atactttcat tttatcactt tcgggcttga 3079561 acctaaaaca gattttataa aaggggggaa aacacctcag ctggtctaga tcactagtct 3079621 gaaaaagagt aaaataaagg tattcaaatt ccagaaaggc ggatcatcta tggcagagag 3079681 tcttcttatc aaagacattg cgatcgtgac agaaaatgaa gtaatcaaaa acggctatgt 3079741 cggaatcaat gacggaaaaa tcagcacagt ttcaacagaa cggcccaagg agccatattc 3079801 aaaagagatt caagcacctg cggattccgt tttgcttccc ggcatgattg acattcatat 3079861 ccacggcggc tatggcgcag atacaatgga tgctagcttt tccacgctcg acatcatgtc 3079921 gtcaagactg cccgaagaag gcacgacgag ctttttagcc acaacgatta cccaagagca 3079981 tgggaacatt tctcaagctt tggtgaacgc aagagagtgg aaagcggctg aagagtcctc 3080041 tttattaggt gcagaactgc tcggcattca tttagagggc ccctttgttt cgcctaaaag 3080101 agccggagcg cagccaaagg agtggattag gccttcggat gttgagcttt tcaaaaagtg 3080161 gcagcaggag gcgggcggac tgatcaaaat tgttacactt gcgccggagg aggatcagca 3080221 ttttgaactg atccgccatt tgaaagacga atcgattatc gcatccatgg ggcacacgga 3080281 tgccgattcc gcattgctgt cggatgccgc aaaagcaggg gcgagccata tgactcatct 3080341 gtacaacgcg atgagcccgt ttcatcaccg agagcccgga gtgatcggaa cggcgctggc 3080401 ccatgatggg tttgtgacag agcttatcgc cgatggcatt cactcccatc ctttagctgc 3080461 aaagcttgct tttttggcga aaggcagcag caagctcatt ttaattaccg attccatgag 3080521 ggcaaaagga ctgaaagacg gcgtatatga gttcggcggc caaagtgtga cggtaagagg 3080581 acgaacagca cttctttcag acggaaccct tgccggttcg atcctcaaaa tgaacgaagg 3080641 cgcacggcat atgcgtgagt ttacaaattg ctcttggacg gatatagcta atataacttc 3080701 tgaaaacgcg gccaaacagc tgggcatctt tgaccgaaaa ggcagtgtga ctgtgggaaa 3080761 agatgcagat ttggtgattg tcagcagtga ttgcgaggtg attctcacca tttgccgcgg 3080821 aaacattgca tttatatcca aggaggctga ccagatatga aagtaatgga atgtcaaacg 3080881 tatgaagagc taagccaaat agcagccaga ataacggcag atacaatcaa agaaaaacct 3080941 gatgctgttc tcggtttagc gacgggcggc acaccggaag gcacgtatcg ccagctgatc 3081001 cgcctgcacc aaactgagaa tctctcattt caaaacatca ctacagttaa tttggatgag 3081061 tacgccggac tttcaagcga tgacccgaac agctatcact tctatatgaa cgaccgtttt 3081121 tttcagcata tcgacagcaa gcctagccgg cattttattc cgaatggaaa tgcagacgat 3081181 ttggaggccg aatgcagacg gtatgaacag ctagtcgatt ccctcggcga cactgacatt 3081241 cagcttctcg gcatcggccg aaacggacac atcggcttta acgaaccggg aacgtctttc 3081301 aagtcgcgaa ctcatgttgt gacattaaat gagcaaaccc gccaagcgaa tgccagatat 3081361 tttccctcca tagacagcgt gccgaaaaaa gcactgacaa tgggaattca aacgatactc 3081421 tcaagcaagc gcattctgct gcttatttct ggaaaaagca aagcggaagc tgttcgtaag 3081481 ctgttagaag gaaacataag cgaagatttt cccgcatctg ctttgcacct gcattccgat 3081541 gttacggttt tgattgatcg tgaagccgcg tcattaagac cttgaaagga acatgctgac 3081601 ttatgaatat caataaacaa tcgcctattc cgatttacta tcagattatg gagcaattaa 3081661 aaacccaaat taagaacgga gagctgcagc cggatatgcc tcttccttct gagcgcgaat 3081721 atgccgaaca attcgggatc agccggatga cagttcgcca ggcgctttct aatttagtta 3081781 atgaaggctt gctctatcgc ctgaaagggc ggggcacctt tgtcagcaag ccaaaaatgg 3081841 aacaagcact tcaagggctg acaagcttta ccgaggatat gaaaagccgc gggatgacac 3081901 cgggcagcag gctcattgat tatcagctta ttgattcaac tgaggagctc gcggctatat 3081961 taggctgcgg gcacccctcc tctatccata aaatcactcg ggtgcggctg gcaaatgata 3082021 ttccgatggc gattgagtcc tcacatattc cgtttgagct tgcgggtgaa ttgaacgaat 3082081 cgcattttca gtcgtcgatc tatgatcata ttgaaaggta caacagcata ccgatttccc 3082141 gtgcaaaaca ggagcttgag ccaagcgctg ccaccacgga agaagcgaat attcttggta 3082201 ttcaaaaggg agcgcctgtc ctattaatta aacgaacaac atatctgcag aacggaactg 3082261 cttttgagca tgcaaaatcc gtatacagag gcgaccgtta tacatttgtc cactatatgg 3082321 atcgtctttc ataaaaaaag cctccaaccc tttttaagga ttggagacat ggcgaaaatc 3082381 aaactggtct ggtgccggac gatatgtttc ttttttcgtc ttgaacttcc agatcggtga 3082441 tttcgttttg ccgttaaaac tgtcttccac tataatgtac caataataaa cagactgcgg 3082501 ttcaagatga tcccagcgga attcagctgt gtccccgctc ttcacttgct cccgttttcc 3082561 gagctcttca ttggtatata cgttacattc aaaataatcg gtttccacct ttttgattct 3082621 tggcttcaaa tcaagcgaaa gggaaaattc atccttgttg ccataggtat ccgtatcata 3082681 gtagttctta tcctttacat acggagagta cgtcgatacg tgcaccatgt cattggcttg 3082741 gtcaaattga agcaaacgca aatacccttg gccgccttct ggcccgccct gataatcggc 3082801 cagcatttga tgcacaagac gatccggttt cccatcacca tcatcatcca gctcatctgt 3082861 ttttctcatc gcactatgat aatgcccgct caacaccatc acgacattcg ggttcggctt 3082921 tacgatttct ttgaatattt tctctccgat tgggcttctg tttccgctga ccagcaaata 3082981 ctcatgaaaa gctaaaatgg ccatccggtc aggatgcttc ttcagcacct gattcatcca 3083041 cgcgatgtct tcatccgtaa tgccccatcc catgtacagc atgatataat cattgccgtt 3083101 gctagaaatc aggtcataat gtccgcggtt atttttatag gaaccgccat aatgaaattt 3083161 tttatcaaaa cgatcgctgc caaaatattt gccaaacgcc ctgtaggagc cgtccttatg 3083221 tccgacatcg tgattgccgg ccagcacgcc gtaaggaatt ccgctcttat ccagaacgga 3083281 cattgaccga tcagcgtttt tccactgtct gatatcggcg gaatcatcta caatatcacc 3083341 cgtgtggaac acatatttga tattgagctg cttttgatta tcttttatcc attcggtctg 3083401 tttatcaaaa atatgcggat agctttcggc gtaatactgt gtatcagaca tccagacaaa 3083461 tgtgtacata tccttcgcag gaggaatttc atcctgtaca atcacattca ttttcgactc 3083521 ccgtacaaaa tcggcggcaa tcacagacgc tttcagcgta aacggtttgt catccttcgc 3083581 gacgaagctg tcaacaggct gccattcgtt tgtccgataa ttccaagcat acatcgtcac 3083641 ctttctcccc ggcaaagaac tgcccttcca gactgattct gccagatcat tctcatcaat 3083701 tgatggatca accgtcactt caaagcgatg ataagggaaa agctctttgt tttctgtcga 3083761 tactgttttt ccatcagcag ctgatacccg ctccaattct ttattcgtaa atggggtctc 3083821 cctttccggc acaaagcttt tcggcggttc agtcagtgac gcgtgcttaa atattttcac 3083881 atgattgcgc gctgtatatt gaaatcccct ataaaaacca acatccatgg catcattcgt 3083941 cggatctttc acccgtacag aaagcttggc cttatgcgtg tcggcttcgc tgtctataac 3084001 ctccggctgg tccggatgct ctcgttcggt tttaaatatc ctctcaatca ctgttttatt 3084061 gcccgcgaga tccgttgctg tcacttttag agaatgtttt cccggcaaaa ggtcagaaga 3084121 tgacgtatga tatgggagtg taatgctttc tccatctaac gacgcctccg cttcctcaat 3084181 tctgctccat ttatcataca tatccgcctg caggataagg tttcctttat acgtttgccc 3084241 ctcggtgata ttcggctcaa tgtgaggtcc tgaattatct acccgtacaa ccaggctgac 3084301 attttccttc ccgtcgcttg cttgaatatg gtgagcgcct tcagaaagct ttgatgtatc 3084361 ccactccagc agctgtgatg taaatagtcc gtcaggcaga ttgaactgaa attgccagct 3084421 tttattcgag cgctgattat cgccaataaa gagttccttc tcaggagaca ccctctgatc 3084481 tctgatcacc gttccatccg ataacaccaa tcgggcgttt ttgactaaga agtcatcacg 3084541 gttttcagcc gtatcaaacg gagacacctt cgaacctgaa cgtatcgtaa tacgctgcag 3084601 ctgcttccct ttccgaagca gtgtctctgg caatggaaca gaataggtgc ggtatttatt 3084661 tgttgtatca tcgaacacct tcagcacttt gccttccatc gttaccgcgt ttttaaaata 3084721 aaggttcgtt ttcctcgtat cgaatgcaaa atatacttct ttttccatcg cgggctctgt 3084781 cacttgtttt ttcccgtcaa tccatagctt aatgctgtca gctcgccctt ctgtcgtggc 3084841 tttgagaaat tgagttcccg acagcgtgtc tctgttttca atattcatcc gcagaccgtg 3084901 cgccttgctt gtttgtttaa tatcaatcat tttgaccggc gttctcgctt cattgatccc 3084961 gtccccggcc gccacataat actctagctg atccttcccg atcaattcag gcgaatacac 3085021 aatataatgg aagagattat cgttgcggtc tttttcagca agaattcgct taaacggttt 3085081 gttctcatcc gtccggtagt aaaaggccac tgttttcact aggcttcggt cccgtatgtc 3085141 agcccgcagc tcaatgcttt cagcagggcg gacaggcttg cggtcagtca aatcctcaat 3085201 gaccggcttt tctttatcga gcttgatttt ccgtttctgg tcgggcacct gtgcctgtaa 3085261 tacggttccg ggagacggat tcttttcccc gattgaaatg ttcagaagtt ctgctgttcc 3085321 gttcagtgga tacttataaa gcactgatga cagccggcgc agcgcatgtt tccgataatg 3085381 cgcaaccgaa atgtcctttc ctgtattcgt tgatatcaca acggcccgcg gcctcgtatt 3085441 ggccataccc tctgtctcgt ctatcaccgc aagatttttt ccttctttta gttgtgtctg 3085501 ataataacga ttgaaatccg ctgacgtcaa ttctggatgc ccggcaggct tcagccagac 3085561 gacaaacgtt tcgccggatg gtatcaagat cctttcatca ggtctccaaa tcagatcgga 3085621 gtcaggccct tcttttgggt agcggtaacg gatatggtag tctttaaaat caatcgttct 3085681 gtcagtcgta ttaaaaatct caataaattc ataaccgtct gcgcgtccta tattcttcgt 3085741 atcaaccgcc agctctgtga tcagaagctc cggaatatgg gcaaggtcag cctggtatcc 3085801 ttcaagcttc agtttcttcg tctccgactc aacccgctgc ttcccattcg acatcacaat 3085861 gtaatactca agctcgctgt tccaaatcaa acgtttcgga atttgtgcca aaaacttgcg 3085921 gaccgctccg ggggtcgggt ccatcggcac cattttgtag cccagctcat tactttgttt 3085981 ataaaaaaga aaggcggaaa atgcttgata cgaattatcg cgaacttgag cctcaatcat 3086041 tagattgctt ctcatttcag ctttcacatc aatttgagga ggattttcaa gcaagggtat 3086101 gtaatgaggc gtttgaaata gttcctgctg tacaacagga aaagctttcg attcatgatg 3086161 gccgccagac aaaacggaaa gaaaagacag taatatagaa gcaataaccg tgtatttcct 3086221 catcaaagca cctccctttt catgtatttt gcgtctgaac agggaagctt atgagttcat 3086281 ttttgtgcat aaagaacaaa aaaacgtctg tctcttgaaa attccactat tacccagtaa 3086341 actaaggata gttaaccagt taacaattaa atcagagagg caaattgatg gacaacagca 3086401 ttcatgatga attatttcaa gctatacaac aattcgcatt aaaaagggat aaacgcgtct 3086461 ggcaaaaggt gcagatacca tccattggca tatcctcaca acatcacgat cacctcaaaa 3086521 aagactggac tttgacccag cttcacattg tttcctgcat acataccagc caaaatgtga 3086581 acaacagctt cttagcatcc cgtttacaca tctcaaaagc cgctgtttca aaagcggttc 3086641 atgctttgtt gaaacacaat atcattacag tgacaaaaaa gcctggcaac aaaaaagaaa 3086701 ttttttatac gctaactgat agcggcagaa aattggcggc attacatgaa cagcttcatg 3086761 agaaagcaaa ggagcaatat aaacagcttt tcaatgaatt ttcaattgat gatttaaaaa 3086821 cagtgactgc gtttttcaac ttgtggatca aatatatgta aaaagagtct cacccgcatg 3086881 ggagagacct ttggaattct attatgcccc gtcaaacgca acgagaagtg aaacaggtcc 3086941 gcgtgtatac agaccggact cagcataaca aaaatcttcc tctaatctga tattccgcat 3087001 cttatccagc acaatattag ctacaatttc gatttcgttt ttggcaaaag ctgctcctac 3087061 acagttatga atgccggatc cgaaagcgag atgccgggcg gcgccgctaa aagcgctctt 3087121 gataccaaga tcttcccgat gaatattaaa cacgtcaggc tgttcaaatg cttcagggtc 3087181 ccggttagcc gcaccgatca tacaaaaaac aatcgtatct tttttgattt ccataccgcc 3087241 gaccactgta tcttgggaca gctgccgcgg aatcagctga accggcggtt tataacgcaa 3087301 tgtctccgca atggctctcg gaactaacga acggtcagcc aaaacatcat tcatctgctc 3087361 aggattgttg agcaaatggt agatcatcag tgccagcgtc ttatcagccg gttccgttgc 3087421 ggctaacagc acattaagaa tcagtgcgag tatatccttg tccgacagcg ccatgccttc 3087481 atattcagaa gtacatagga tcgaaattaa atctgatccc ggattgacgc gacgttcttt 3087541 aatgaccggc atcaagtatt gggaaagctg ttcgctgcac cataacgaat gtgcccgcgc 3087601 ttcaggagat tgagagatac tcgtgataaa atcggcaact ccgctgtgcc actcagagat 3087661 tttttcatgg tctcttttat ccagcccgag catgtccatc gtgacgcaca ccgcaaacgt 3087721 ctttccaaaa tcattgacga gatcactttt ccctctttca agataaggcg ctaacaagtt 3087781 ttctgcattt tgtttaatca atggagacag atgatccagt gcgtcaccga taaagcttct 3087841 cactacaatt cttcttttgg cagagtgttc ttttccatgc atttgggcca gcacagggcc 3087901 tcgcatgact ggttcggcac gctcaacaag tgatttcgtc gtgaagatat ccggatgctg 3087961 aaggatatag cggacatcat gatagcggct gataaaataa ctgtctatcg actcttcata 3088021 atgaaccgga tcttcctccc gcagttgtga aaaataagca tatggattgt tttgaaattg 3088081 atcagaaagc acactaaaca atttaatcga ttggctcatg ttttactccc cctatcatcc 3088141 ttcagatgtg atccgtttct cagaaagcat ctgcgccatt tcctgtacaa tgagataccc 3088201 ttgattcggc cgcatacaaa tagaaaattc atggttactg atcttctcac ccagcttcca 3088261 cggacgatga taagcaagga gtgtctcttc cacctctaaa atatccggag ctccgataaa 3088321 aaacggcagc tcagctatga catattccac agccaaattc agcatatcct cactgacttc 3088381 ttccatcatc aaactgacgc cccgcgcacg cccgattatc gcttcacgag acatgtccaa 3088441 acaagcatgt cgaaaatgag gctgctcaaa aaatgcatgt tcaacttctt gtctcaacag 3088501 ctggtaggct ttgttatcta taaaatcaga aaatgtatga atcgccttcg gatccccgcc 3088561 atgagccaca agggctcttt ctgcaaatct cctgtttcgt gatacctctt tccttacttt 3088621 tcgttcagcc tttcctctcg gagttccaag cgcttctaga agattagccg cctcatgccc 3088681 tgcaagtaaa actgaaacgc ttttaaattg agctttcgcc catccaatta atctgtaaat 3088741 ataatcctct gaaaacctgc tgttaaatgg gctgatcccc accaaaacat gcctgcgccg 3088801 ttcaaatatt tctctgcagt tttctgttaa tgcctcagca ataaaatgca cagaccttct 3088861 ttccgttacc attccggtca tctcattcac ccctaaaact tatcccgctt taagtcatca 3088921 ccctcaaata caagatggaa tagctagaac aactgaacaa gacgaatggc aggcatcact 3088981 taaagtttcc aaatgttttt taagatttta ataatcattt tcaataccca tatcatgata 3089041 aatgtttact agtaaacatt agtcatttta tcccttttcc ttccaaacgt caatatgatc 3089101 tgtgcccaaa tatttgaaaa taaatgtaaa catcacattt tccacacact ttttacacgc 3089161 atattcagca tgacatatca acaaatagtc taaacaccaa caattgacaa cgaaaacaag 3089221 aaaagataaa ataaaattgt tcaccagtaa acgatttgtt ttattgtttc atcgtaaact 3089281 attattccta agaaagaagg tagcctatgt ctgatttgac aaaacagatg atatacgaca 3089341 tatacgtgag actgctgcac cttaatgaac aaaaagcgaa cacttcactt cagcaatttt 3089401 ttaaggaggc cgcagaagag gatgtagctg aaattcccaa aaatatgaca agcattcacg 3089461 tcattgactg catcggccag catgaaccca ttaataatgc cggaattgcc agaaaaatga 3089521 acttatcgaa agcgaatgta acgaaaatca gcacaaaact gatcaaggaa gaattcatta 3089581 acagctatca gctgacagat aacaaaaaag aagtttattt taaattaacc cgtaaaggca 3089641 gacggatttt cgacttacat gagaaactgc ataaaaaaaa ggagctggct ttttaccaat 3089701 tcctcgattc attttcacaa gaagaacaaa aggctgtatt gaagtttcta gagcagttga 3089761 cgtcaacact tgaagcagaa caaaccgatg ggactccaga caaacctgta aagtaaacaa 3089821 aaaggcggtg tacactttgg ctcatacaaa atcaaaggca gtattgatct tatacactgt 3089881 ttgcttcagt gcattttttg catctttaag ccagaacatt tattcaccta ttcttccgat 3089941 cattaaagaa tcattccatg tttccacagc tatggtgaac ctgtcagtct cagtttttat 3090001 gattgtgaca gcaataatgc aaattatatt aggagcgatc attgatttta aaggcgctcg 3090061 gatcgtcttg attaccggta ttctggcaac ggcagcagcc agcatcggct gtgcggtgac 3090121 tactgacttt accttgtttc tgatattcag aatgatacag gcagccggtt ccgcagcact 3090181 gcctcttatt gctgccacaa cgatcggaca gctgtttaca ggaaatgaac gcgggagtgc 3090241 aatgggaacg tatcaaatgc tcctgtctgt cgcaccggct attgctccag ttctaggagg 3090301 attcataggc ggagcagccg gatacgaagg gattttttgg atacttgcgg ccatctctat 3090361 cgttttgctg gtgacaaaca gcatcacctt tcctaaagat tctccaactg aatctatgca 3090421 gcaagccaaa ggcaatgtgt tcgctcatta taaatcaata tttacaaatc gaacagggaa 3090481 cgtcattttg actttaagtt ttgttctctt tttcatttat tttgcagtaa ttgtctacct 3090541 cccaatattg ctgacagagc attaccatat agatgtgggt atagcaggac tgttatattt 3090601 gccgctggcg ctgagcacga ttgcaggtac gtttctgttt aaaagaatac aggcaaaaat 3090661 cgggctgcac accttgttta tcggaagcaa tgtgattgcc gcctgcagca tcattttatt 3090721 tgctgttaca cattccgttt ctctcgttct catggctctg acgctggcac tgtttggcat 3090781 ctcgatgggg gttattcctc ccttgtactc tacaatgatt actaatgaat ttgagcacaa 3090841 cagagggagt gcaatcggaa tgtttaactt tatccgatat acaggcatgg cagcaggtcc 3090901 gatggtatct gcctacttgc tcacaatgat gccgtctgcc atgtccttta gcctcctagg 3090961 ccttggattt gccgcattga gcttttgcct tcttccgcca atgttttcgc cgcagaagcg 3091021 cacgaaacaa aaaaagcacc acatgtaaaa aagctgcctt tgcgggcagc tttttttatt 3091081 tttttctaag cggctctaaa atgccttttt gaatcagcaa atggaagacc gacaggataa 3091141 cggatgccca tatcgctgtg ccgaagccgt cgatttgaaa gctgtcaccc ataatggacg 3091201 cggtcatcat aagcgtgatg gcgttaatca caaacaagaa gagtccaagc gtcaccatgg 3091261 tgaccggcag tgtaaatata attaaaagcg gtttaatcag cacgtttaag atcgataaaa 3091321 tgaggctggc gataatcgct gccccaatgc tgctgatatg gatggagtca atatatccat 3091381 caatgacgat taataacaat gcattgacta aaatgctgac tgcccatttt accatgtcat 3091441 ttcatatccc tttctgacgg gacgataaaa atccaaatga tataaatgag caaaaccggc 3091501 aagacacttg tcataatggc taagatgaca gttatgactc tgaggagtga tgcgtcccaa 3091561 ttgaaatatt ccgcgagacc tccgataaca ccggcgattt tcttattttt ttctgagcga 3091621 taaagcttat tcattcgatc acctctgtga gtactttagt ttgatggcgc ctgttagtga 3091681 ttctgagaag acggtgatgt tttgatcatg tgcctgattt gaagtgaaca tcatttcttt 3091741 ttgaatcgta tcattttttt ccttcagcat ctctacatcc attaattcat gggacagcgt 3091801 accaagattg cttttcagct ctgccttcac tgcgagatcg tccggaattg caagctctac 3091861 atttccagtc gttgtttttg cataaatgga gcggcagtct gattctgtta cgttaatcgc 3091921 aatatttccg ttaaagcttt gaacgtcaat ggattcgctt ttccctcgga gatcgatcaa 3091981 tccgttaatg gtttccgctt ctatcgtacc gcagctgtgg cttgcgagct taatttgccc 3092041 gttggccgtt tcagctatgg ctttttcggc tgttaaatac gagaacgaca gcacgccgtt 3092101 tgtcgttttc gctgagaact cttttacatg taaatgttcc cctctgactg gaccgttaaa 3092161 cagcttcacc cgaatcttat catactcctt ctgaggaata tacaaagtga cattcgtttt 3092221 catcgtcttt ttctcagtac ggataaaaaa cttattacct ttgatttcac attcaatatg 3092281 ctgaagaaat gcgtgtctcg ccgcatcctg gctgtcagcg cgatatacct tcgcctggca 3092341 ttccgctctg atatcgtcat cttcccaagg gacgatattt acgctgccat tggcaatttg 3092401 cagctcaaca ctggaaaagt cagtatcttt aaattgaaaa atgtgctgaa catcatacgc 3092461 atggccaaag tttaaatcaa ggtcaacttc cttgaccttt ttcacagcag aatcaatcca 3092521 gtcaaacagc ttggctccta aagacggttt gccgctttct ttttttgccg ttgtaaatgg 3092581 ctcttcctcg tcatgaacgt gaactgagag cgctgtgatt ttctcttctt tttccttgta 3092641 gtcgctgtca agcttttcaa tcagtgtcaa agcttcttgt gctgtaagct ttccttcctc 3092701 aacaagctta aggattcgtt ccttttcttg cttcattacg atctcctccc cattgtctac 3092761 ttatgctgca cgcaggacct taatgccctg aatcacattc caaatgataa tgccaatgac 3092821 aactaagaaa taaataaccg ctcccccgat gattacaaat acaggaagca agctgtctcc 3092881 atcaatcgca acggctccgc caagtaaagc aataaaaagg aacagccagc cgacaaacgg 3092941 aacaatgtga gaaataagag agcgtatcgc atggcgtttt gtttctttct catttacaac 3093001 aaaatatgcg acaatcggca caatgattgg cgcaatgaac acactgaaat aacaaagtga 3093061 tgcaataata gcttgattac ggttcaattc attccacact cctattgtga attgtccatg 3093121 acaaaagatc agggacgttt tacttattta tacgtttaaa atctcttcag gtttcaaatt 3093181 cattctttag acatgctccg atttacggaa attggatttt aaaaagtttt agaagtagaa 3093241 tcttccggct ataccgatta caatatgtaa aaagcttacg gcaaccaagg aggctggaca 3093301 agcaatggag aaagatccca gtgactatac agtaacacaa gaatcagtgt taaagctgat 3093361 tcaggaacaa aaaagaatga atcgtgaaat gatcaccgag cttgagcaga ttcacggacc 3093421 cttcccgatc tctcacgata tccaatatat aaaagtgctg ctcgacagca gcaacacaca 3093481 tattgttcaa gatttaatga gtgtaagtaa gcagctgtat aagaagactt tgtaattgcg 3093541 gaaaacatat cattcattat aactgaaaca aagctaaagg ttagatgaca atatcttgcc 3093601 ttttttgttt tgaaaaaaca agtgattccc tggctgtcac aaaatgattg taacaaaaaa 3093661 agcctgccgg cacatccagt taatggactc tgtcggcaag ctgtaactat cagaaagaga 3093721 tagccgttca aaattaacgt aacaattgaa gcacgttttg cggctgttgg tttgcttgag 3093781 caagcatcgc ttgagaagct tgagaaggaa tgttgttctt tgtgaactcg ctcatttctt 3093841 tcgccatgtc aacgtcacgg atacgggact cagcagctgt caggttttca gaagaagcac 3093901 caaggttgtt gattgtgtgc tctagacggt tttgtaccgc accaagttta gcacgttggt 3093961 ttgagacatt gttgattgca gtatcaatac tttcaagttg tgtatcaaaa ggagtattag 3094021 caaaatctgt tacattaagt gcgtttactc ctaaagcagt tgatgacatg ctgtcaatgt 3094081 taactgtaag ctgctggcca gcatttgctc caatttggaa agtgaaacca tcagtttcag 3094141 taccatctaa taactttttg ccgttgaatt cagtacgatt tgaaatgcca tcaacttcct 3094201 caataagcgc atccatttca tctttaattg caccaagatc ttctgcttgt tgtgtacctg 3094261 tgtttcctgc ttgaacagta agttcacttc taaacctatt atgccgtaaa gaaaaagctt 3094321 gcctgctaag cccaaggatg gacttgccga caagctgtcc cctcttaaca gagggtttta 3094381 agatgtagct gtttcttttg ctttcaagag cgatttcatg cgtgttttgt cacgttcgat 3094441 aacaggcttt aaataacggc ctgtatacga ttcttcaact tcagtgattt cctcaggcgt 3094501 tccagacgcg acaatggttc cgcctccggc tccgccttcc gggcccaaat ccacaatgta 3094561 atcggccgtc ttaatgatat caagattgtg ctcaataacc agtacagtgt ctccgttgtc 3094621 taccaaccgt tgcagcacga caagaagcct ggcgatatcg tcgacatgca aacctgtcgt 3094681 cggctcatct aaaatgtaga gcgtacgtcc ggttgagcgt ttgtgcagct ctgacgcgag 3094741 cttcacgcgc tgcgcttctc cgcctgacaa ggtcgtcgcc ggctggccga gcgtaatata 3094801 acctaaacca acatcataaa gggtttggag cttgcgtttg attttcggga tattttcaaa 3094861 gaaagaaaga gcatcttcaa ccgtcatatc aagcacatca gagatgcttt ttcctttgta 3094921 cgtcacttca agcgtttcac ggttatagcg tttgccgtga cacacctcgc atggaacgta 3094981 tacgtcagga aggaagtgca tttcaatttt aataatcccg tctccgcggc aggcttcaca 3095041 tcgtccgccc ttcacgttga agctgaaacg gcctttttta tagccgcgga ccttcgcttc 3095101 atttgtctgc gcgaatacat cacgaatgtc atcaaataca ccggtgtatg tcgcagggtt 3095161 ggatctcggc gttcttccga ttggcgcctg gtcaatgtca atgactttat ctaaatgatc 3095221 caaaccttta atctctttat ggctgccggg cttcgctttc gctttatgaa gcttttgcgc 3095281 cagcgcctta tgcaaaattt cattaacgag tgtactcttt cctgaaccgg aaacacctgt 3095341 aactgctgta aacgtcccaa gcgggaactt ggcattcact tttttcaggt tgttttctga 3095401 tgcaccttta atttcaatgt aacgtccgtc cggctttctt ctttcaggag gcaatgggat 3095461 aaactttttc cctgataaat agctgcccgt taatgaattt ggatcttcca tcacttcttc 3095521 cggcgtaccc gcagatatca cctgtccgcc gtgaatgccg gctcccggtc caatatctat 3095581 taaataatct gctgccatca tcgtgtcctc atcatgttcg acaacaatca gcgtgttccc 3095641 gaggtctctc atatttttca gagcgctgat caagcggtcg ttatcacgct gatgcagacc 3095701 gatagacggc tcatctaaaa tataaagcac accggataaa cgcgagccaa tttgagtcgc 3095761 cagcctgatg cgctgcgcct ctcctccgga caatgtaccc gctgccctgc tcaatgtcag 3095821 gtaatcgagg ccgactttgt ccagaaagct taagcgctcc acaatttcgc gcaaaatcaa 3095881 attggcgatc tgcatatcct tctcagaaag ggtaagatct ttaaagaagg caagtgcgtc 3095941 ggcgacagac agctcggtaa ttttcccaat gtggcggccg tcaatcagta cggcaagcgc 3096001 ctctttcttt aaccgatagc ctttgcacgt cggacaagac ttctgagaca tatactgctc 3096061 catttgctca cgtatgaaat cggagcctgt ctccttatag cgtctttcaa tgttgcgcaa 3096121 tacgccttca aattgaattt caccttcgcg gatttgtcca aaatcatttt catatcggaa 3096181 ataaatcagg tcatccccgc tgccgtacag cactttatcc agttgatgct tcggcaaatc 3096241 tttgaccggc acatccatat caatcccgta gtgggtgcag actgcctcaa gcagctgagg 3096301 ataatattgt gagctgatcg gtgtccaagg ggcgaccgca ttctccttca atgacaaatc 3096361 ttgattgggg atgacaagat cggcatccac ttcaagcttc attccgagac cgtcacacgt 3096421 cggacacgcc ccgaacggac tgttaaacga aaacagacgc ggctcaagct caccaattga 3096481 aaatccgcag tgcggacagg catgatgctc gctgaacatc agctcttcct caccgatgac 3096541 atcgatcata acccgtcctt cacctaaacg aagcgccgtt tccaatgaat ctgacagccg 3096601 ggctgccacg ccttctttca cgacaatccg gtcaatgact acctcaatgg aatgcttctt 3096661 gttcttttct aattcgatat cgtcggaaag ctcagccatc tcgccgtcaa ttctgactct 3096721 gacatagcct tgtttcctaa tctgttcaag cactttgaca tgagcgcctt ttcggcccga 3096781 gacaatcggc gccagcacct gaagcttcgt ccgttccggg tattccagaa ttctgtccac 3096841 catttgctcg atggtctggg atgtaatctc aattccgtgt tccggacaat gaggcttccc 3096901 tactctcgca tataaaagac gcagataatc ataaatctca gttaccgtac cgacagtaga 3096961 cctcggattg cggctcgttg ttttctgatc aatgctgatg gcgggagaga gcccctcaat 3097021 tgcatccaca tccggcttat ccatttgccc taaaaactgg cgggcatagg cagacagcga 3097081 ctcgacatac cgtctctgtc cttcagcata tatcgtgtca aaggcaaggg aggatttacc 3097141 tgatccggac aaacccgtga caacgacaag ctgatctctc ggaatcgtta catctatatt 3097201 tttcaggtta tgcgccctgg ctcccttcac ctctatccga tccatagcca tttgttcatc 3097261 atccttccgc ttttagctct aaaagtaaat cgcgaagctc cgcggctctc tcaaagtcaa 3097321 gcgccttggc ggcttccttc atttcatgct ccatctgttc aacgactttc tggcgttctt 3097381 tcttcgtcat tttcgacagc ttcggcgcgg cttttgtttt gtattccgct ttatcctcag 3097441 ctgctactgt ggcacgaatg acatcgcgaa tttctttatt tatcgttttc ggcgtaatgc 3097501 cgtgctcttc gttaaaccgc tcctgctgct cgcggcggcg ttttgtttca ttaatcgcaa 3097561 tttccataga cttcgttatt ttatcggcgt acataatgac gcggccttcc gcatttctcg 3097621 ctgcccgtcc gatggtctgg atcagcgacc gctccgaacg aaggaaacct tccttatccg 3097681 catccaaaat cgcaacaagg gatacttcgg gaatgtccaa accttccctc agcaggttga 3097741 tgccgacaag cacatcgtac ttgccaaggc gcaggtcgcg gataatttca atccgttcaa 3097801 gcgtcttgat ctcagaatgc agatagttta ctttaatgcc gatttccttt aaataatcgg 3097861 tcagatcctc tgacatcttc ttcgtcaaag ttgtcacaag cacccgttca ttccgctcga 3097921 ttcttgcttg aatttcgccg atcaagtcgt caatctgacc ttcgattgga cggacgtcaa 3097981 taagcgggtc aagaagcccc gtcggacgaa tgatctgttc gaccatttca tctgtatgtt 3098041 caatctcgta cggccctggt gttgctgata catacacgat attgtgcata tgcttttcaa 3098101 attcctcaaa acgaagcgga cggttatcaa gcgctgatgg aagccggaag ccgtgatcca 3098161 cgagcacctg tttccgcgcc tggtctccgt taaacatgcc gcgcacctga ggaattgtca 3098221 catgcgactc atccaccacg atcataaaat cgtctgggaa ataatcaaga agcgtatacg 3098281 gcgttgaacc tggaggccgc agagtcaaat gtcttgaata gttctcgatg ccggagcaga 3098341 aacccatttc acgcatcatt tcaagatcat atcttgtccg ctgctctaaa cgctgcgctt 3098401 caaggagctt tccgttttca tgcatgacct tcagctgctc ctcaagctcc ttctcgatat 3098461 tttgaatcgc cttctccatt ttctcggccc gcgttacgaa gtgggatgcc gggaaaatcg 3098521 caacatgatc tcggtcgccg agaatttctc ctgtcagcgc atctacttcc cgaatccgtt 3098581 cgatttcgtc accgaaaaat tcaactctga cacaatgctc atcacgggat gccggaaaga 3098641 tttccactac atccccgcgc acacgaaatg taccgcgctg aaagtcgata tcgttgcggg 3098701 catattggat gtctacaagt tttctgagca gctcgttgcg ctcaatttcc atttcagtcc 3098761 gcagtgacac gaccatttcc cggtattcct caggcgaacc gaggccgtat atacaagaca 3098821 cactcgcaat aataatgaca tctctgcgct caaacaaagc tgatgtggcg gagtgtctca 3098881 gtttatcaat ttcatcatta atactagcgt ctttctctat aaatgtatcc gtttgaggca 3098941 catacgcctc cggctgataa taatcatagt agctgacaaa atactcgaca gcattgttcg 3099001 gaaaaaattc cttgaactca ctgtaaagct gtccagcaag ggttttgtta tgggcaatca 3099061 cgagagtcgg cttattgact tctttaatca aattggacac cgtaaatgtt ttcccagttc 3099121 ctgttgcacc cagcagagtc tgatgcttct tgccctcctg aattcctttc acaagctttt 3099181 caatggcttt cggctgatct ccctggggct gatatttcga gactaactca aagcgatctt 3099241 tcacaaaaat aagcctccgt ttctttaacg aaatcttcct atagatatag taacacaatg 3099301 gaaagcaaaa tcactaaaaa tacgaactaa agttcggtgg ttttttattt ccagctgttt 3099361 ttgtgtataa aaaacctgct tttaaaacgt aaaagcaggt attcagtctt tatattcatt 3099421 atgtccgatt tattcttctt ttttctctgc agcttttttg gccatataca gtccgccagc 3099481 cacaagagac acaacatcca atcctacaat aaaatacgtt tctgtatagc cttttaaata 3099541 agaggcaaac agcaatgcag ctgttaaagc gatcgccaca taatgattaa aggtgactct 3099601 agtaaataga acaacaagca taaaagggaa aaacaatgca aaaacggctt ttgtaatcaa 3099661 caaaaaccct cctcagggat tcttcatctg atctgattat agtaaaaaat gaagaatcgg 3099721 acaatcgtgc attcgctccc tctacttaca ccatacccct tttcagccaa aatcaatcac 3099781 catatttgca ttttggtgcc ggtcaaaact tattccatgg tgccgctgtt ctaatcagcg 3099841 gcactttttt tattacatca tcaagtccgc cgccagattc cgagaataaa agaaaatagg 3099901 catacagtac cagtacggcc gcatttttca ggataatata accaacttaa ctattcattt 3099961 tatttaggac tttctgcgtt tgacagcatt ttcctgaaaa cctacaatta aatgatagtg 3100021 tttactatca ttttttaaac acaggctccg caataaaaag actagagaga aaaacaaaat 3100081 gaatgaagaa aagaggggtt tcaaatatgt attctgtttt atttcgccag gcagaagagt 3100141 ccagccagct ggctggagca aaaggaatga atttgattaa attgaccaaa cacggtcttc 3100201 ctgttccgga cgggtttatt attcaaacga atgcgctcgc acgttttatg gaggacaacc 3100261 agcttcaaga gactagtgaa aacgtcgaag gcgggatcat ttccggaaca ttttcggatg 3100321 agctgaaaga tgagctgact agttcctttt ataagcttag agaatcatat cgatccgtag 3100381 ccgtgcgttc ttcgtctgct tcggaagatt tagaaggcgc ctcattcgcg ggtcaatatg 3100441 aaacctactt aaatatcaaa acagaggaag agtttctggc taaagtgaaa gaatgctggg 3100501 cctcattttt ttctgggcgg gtcagcagct ataagaaaaa aatgaacaat caaatcgcag 3100561 agccgttaat gggaatagtc gttcaggggc tgatcgattc agaaatgtca ggtgttatct 3100621 tcagccgcaa ccctgttacc catgatgata gagagctttt aatcagcgcc agctacgggt 3100681 tgggtgaagc tgttgtttca ggaaatgtta ccccagacac gttcattgtt aataaatctt 3100741 cgtttgagat tcagaaagaa ataggtgcaa aggaaatcta catggagtct gcggcagaag 3100801 gaattgctga aaaagaaacg agtgaagaca tgcgcagccg tttttgcctt acagatgaac 3100861 aagtgattga attggctgaa atcacaaaaa aaaccgaaga cctgtacgga tatcctgttg 3100921 atatagaatt tggaattgct gatcatcaaa tataccttct gcaagctcgc ccgattacaa 3100981 ccattgatca ggacaaaaaa gcggcagaag aaaaacgcag cttcatgatt accgacactg 3101041 atatgaatga tttctggctt aacatggagt ctaatattga aggtccggtg agtccgttat 3101101 tttcatcctt catcgtgccg gcattggaat atggcttgaa gaagagcatg caaaagtttc 3101161 cgattggtgt agttgttgat gaagtaaaac tttatcgcgg acatatttat tccaaaaacc 3101221 aaggcggaca gcagcctcct tctgaagact gcggcaaaga gcttttcccg attttatcgg 3101281 agcatatgta tgacatcatc aatcacacat acctcccttt ttaccggaca ctggaccagc 3101341 tcgcacaaac tgagcatacc gcagaaagcg cactggaagc ttttcaaaaa ctaaaggcct 3101401 tttatctcac ggcttatgaa gagcacttta atatcgtttt cccgcaaatc cttttaacaa 3101461 acaaactgca agcgatgtat caggacattc aaggagagtc cgaaaacgct catttttacg 3101521 agatgctgac aggaaaaatg aacaaatcac tggaaacgga ccgttgctta tggctatttt 3101581 ctgtggaagt tcaggagaac ccgaaccttc tggccatttt tgaaaacaac aagcctgaac 3101641 agctccagga gaaattggaa caaacagatg agggaagaca cttcctgaag aacgtccatg 3101701 aattcttgca agaatacgga tggagatctg ttaaaagtca tgatctgatt gaacaaatct 3101761 gggtggaaaa tccgtatttc gctctggcca atattcaaaa ttatgtccgt aatggctatc 3101821 attttgacaa tgaatttcag aaaacaaaag aaaaacgaga gaaattatac aatgaattct 3101881 tggaaagcat agaagatccc ggtttacgca ccgaatttga ccgctattat caatggacac 3101941 tgaactctgc aaatataaaa gatgatcacc acttttatat tgacgccatg ctggatgcca 3102001 aggcgagaat ctttctgctg aagataggtg aattgctggc ggaaaacggt gtcattcaag 3102061 atcgggagga cctttggttc ttatatgacg acgaagtgga acaagcgctt cttcaccctg 3102121 tatccctgca agaaaaggct gaaaaacgca gacagatttt tcatgagtat gagctggccc 3102181 aagccccggc ctacctcggc accccgacaa aagaacagct caaagcagct gaagaaattg 3102241 tcggcgctgt gatagaggat gaaaaaaaca cagagaatca tatttttggc attgcggcat 3102301 caagcggcat tgcgacaggt ccggtgaaaa tcattcggga cgccaatgaa ttttctcaat 3102361 tcgcgcctgg agacgtactc gtttgcaaga tgaccacacc gctatggacc agcctgtttc 3102421 aagacgccaa agcgattatt acagacacag gcggcatttt gtctcacgct gcgattattg 3102481 cccgtgaata cggcattcca gccgttctcg gcacacgcac ggcaaccgaa agactgcgag 3102541 acggtgacat catcactgtt gacggaagca gcggcaaaat cacagttgtc agccggtcct 3102601 gatgcgtccc cctctttctt atacaagcgg ggcgggtgta tacttgtcct gccagtatat 3102661 tcgtgaggtg aaacgtattg agaccgacaa acaagagaat ccttgatgct gccatgcagc 3102721 tgctcgtcaa aaaaggatat cgcgcaacga ctacaaaaga aattgcagaa aaagcaaatg 3102781 taagtgaagc gacgattttc aggaacttta aaaacaaaca aggactagtt gaggctttgc 3102841 tttctcagca ttcttcaaac agaggcagca ttttggaaca aacagaaggg gatttgtaca 3102901 aagacctgct tcatatcgga acctgtctct tggaggagct cgaacataga aaagatatca 3102961 ttaaaatcag ctttcgtgaa ccggccatgt ttcaggatgt cattaaccac gtcactgaat 3103021 atccccaatc tatgaaacag ctattggttg attatctcaa aacgatgggt gagaaagggg 3103081 ttattcagac aggaaatgaa gcggaacatg ccgacgtgtt catgtcgatt atcttcggtt 3103141 atttcattca ccgtctccac ttaggagacc gggtcatatc aatgccccag gaaaaaatgc 3103201 tggagcatag cacagctcta tttgtcaaag gaatttctgc tgattaactc cttggcataa 3103261 taaaaaggag gatcccaatg agctcaagaa aagaatgggc gctgatcgtc tcgctattat 3103321 tgggggccat tctggttccc attaactcaa cgatgatcgc ggtcgcgctc tcatctattt 3103381 cccatacgta taacgagtcc atcgcaagca tcacttgggt ggttaccgtt tatttaatcg 3103441 tgatggcagt cacacagccg attgcaggaa agctcggtga catgtacggc aataaaacaa 3103501 tgtacttatg gggagtcggc ctttttctaa tcgcatctct aggctgcgcc ctttcaccga 3103561 gtctgctcct gttaattgtc tttcgggcat tgcaggctgt cggcggggca ttgcttacgc 3103621 caaacagcat tgccattatc cggcatgttg tttctgaaaa acgcctaccg aaagtgtttg 3103681 gatttttcgg actgggcgcg ggacttggtg cagcactcgg gccttttatc ggctctatac 3103741 tgattgacag cttcagctgg cattcgattt tttgggtcaa catcccgttc ctcgccattg 3103801 ctttatttac ggcattaacg atgtttcctc aatataaaga aaataaatct gacgcgccgc 3103861 tggatatcat cggctctctc ttgcttgcag gcagcatcgt ttccattatc ctgctgacga 3103921 aaaatgaggc tccatgggga tatactgtat acagtgtatt gatacttctt tttgttccgc 3103981 tttttttcag aagagaaaaa cgtacccagc accccatcat tgactttgca ctgtttaaaa 3104041 gctcaacctt tacaaatgcg aatctatcag tcttgttaag caatttgatg atgtatgccg 3104101 tcttattgat tatgccgtta tttatgacga accaatttgg gcttaataca tctaacagcg 3104161 ggatggcgct ttctgtattt tcgatcttca tgtcagccag caactgggtg ggcgcgcagc 3104221 tccatcacaa atggggagcc aaaaaaatca tttttctttc atttgccatg atggctggtg 3104281 cgaatctatt atttttgctg ttaagcagct cgcattctgt cttgttcctc atgctctctc 3104341 ttatccttgg cgggctcgct tccggagtcg gtctgaccag catgcaggtt tcatcccttg 3104401 ccacagtaga ccccggtatg tcaggagtgg catctgggat tttctcgacc ttccgttatt 3104461 tcggaagcat catttcatca gccttaattg gcctgatttc gggatatcac accctattta 3104521 tgattctctt tgctgtatcc atcatcggcg tttttgtttc attgggcatc aaatctgatg 3104581 aaacggcacg gatagaaaaa aactcagcgt aacacaaaac agcccggcat cgcatcatcc 3104641 tgcggtgccg ggctgccttt tatgatcccg aagcgactgc ttcgtcttca cggtcatcct 3104701 ttacgaagag gatgcccaat tcatgatgtt ctccttcata agaagctcgc tggtcaaaac 3104761 gaatttctcc attcaaaccg ataatttcaa gctttacata tgcacggtta tgctgaagcg 3104821 cttcatagaa atcagaaacg ttcttaaccg gtatgccatt gactttcgtt atgatttccc 3104881 cgattttcaa ttccagatcc tcagccggcg tattggggat aatcccaagc accattaagc 3104941 cctgatccct tttcgagaaa taaaacggag ccgcgttatc attcactctt tgctttatgg 3105001 acagaaaaat acgccctaac aaagcggtac agaccgctgc acccgcaagc ggcgtccaca 3105061 gtaagctcgc tgcaccgaga actgcgacgg caagaccgag aatacaaacg cgtttcgctg 3105121 tgatccttat actcgtttca ggcagcgatc cctgtaccct ttgtccaaat ccgacaaagt 3105181 aaggaatcca tagaaaatgg aatgagccgc cgggaaccgt aaacacgggc caccagctaa 3105241 ggtgcgattc taaaccatta ccgggcacga gaaggaacag cggcaaaagc caaacccggt 3105301 ttgccagctg ctgtccgatc ggcaaaccgc ggctgcttac gacaagtgcc ggtgatgttc 3105361 tcacatgcgc agaacgataa gcaaccgctc cttcagtgat aatcagcaaa cctagaaaca 3105421 cagccacagc cggccaaaca actgcaaatc cttgcggaaa tctctccaga aagggctccg 3105481 cctgatatat ttgcagtcca aaacctatca gcatactcac actgacgata tatgcagcag 3105541 acatccagtt tgcgcgaaga gtgaacgctg ccgctgcagt gataacggca ataatcgcaa 3105601 gtaaaccgag aggaatcgat attccgagtc cacctaaaat aactgacaaa agaagacctg 3105661 gaatcagtcc ctttgtatat gtaaatttca gatcatcata aatatctgct attcttgtat 3105721 gaaaggtttt tcgttcccgt ttgattctta catagccgaa agccaaggtt atgatgataa 3105781 aaaaccagaa aagcgggtgt aagaagaaca agcccgcgct ttttaacagt tcaattcccc 3105841 attgaacaga cactatctct caccgcctca agccaaacat gttactcata ttctatcaaa 3105901 tattaaatgg cttggatatc ctcaggagag tttatctctc ttgcgtcatc cacagcgtga 3105961 cattcgatag tgaaaaatcc tttaaatagt ggtttacatc cacatccaat aacccgctga 3106021 ttagatgcat cgaccttttt atatctgtca gattaattcc taatcgctta tggtttttca 3106081 ttaagtagtt aaaataatgt ttggcgcatt cctcattaat gtcatttact gattcgacat 3106141 tggtgtaatt gaccaaatat ctgctgaaca gcataagaag acttagtgct tttgtagctg 3106201 aaaatgttac gtcttgtgtt ctgtctttta attgttccac taattcataa tatttttttt 3106261 tcacgcacaa tacttgccct cttcaattgt gaacccccat tttctttata cagataagca 3106321 cgggccagta taagcagcag tactggagtg ctaacaagca ttctcgctaa cgttactctt 3106381 taaatacctg tcgttcagct gccattaacc tgattactgt tctttttaga accttcttat 3106441 attgtatgaa gtaaacaaag actaggcaac ttgcaaaagt ttcattttaa atgcatatta 3106501 actcgttaga aagtctctct catatattga tatcgggtaa taacagtcct ttataaatgt 3106561 ttatttgtga aaattttttt aatttcttgt caaaaactca ttttttatgt gacttatgat 3106621 ccataatctc tttaagcaca aagaaacagg agatgaaata ccatctcctt taattgacaa 3106681 ataatgattt caatgctgtt tgaagctgca aatcattttt ttcatctgat tttttctttt 3106741 ctatctgctg atttaatgtc tctgcagtgc gagtgtcgat cacaccggtt ttattcagct 3106801 tgttttgatc ctgaaaagcc ataaccgctt ttttcatgtc tttgctgaaa tagccatcct 3106861 cacgtcccgg atcaaagctg agacctttta acaatacctg cgcatgcttg acgtcttcat 3106921 tgttcatgtc cactttaagc ggctctttca gctgtaaggg cccggcggaa aaataatcgg 3106981 gctgcttaat cgcaatggtc ggttcaattc ctttcttatg aatccagttt ccatttggcg 3107041 tcagccactt gtaaagcgtt aatttgatgt tgctgccgtc ccccattggc acagcctgtt 3107101 gaaccgttcc ctttccaaaa gacgtatcgc ctacaacatc ataatggcca gcttccttta 3107161 atgcgccggc aagaatttct gatgcagagg cacttccttt atccgtaatc acattgacag 3107221 ggtacgcttt tttatgggtc aatgttgaaa aataacgttt tttatctcca ttgcgttcag 3107281 caatctgaat atacggctga tcctttgtaa cgaaatgctt aagaatttct tccacacttt 3107341 gaagatatcc acccgggttg ccgcgtacat caatgacaag tccttctatt tcttttttct 3107401 caagctccct cagcgctttt gcaaaatcct ctgcggtgtg ctcagaaaaa gtagagatgg 3107461 caatatatcc gacagaatgc ccctgtactt ttttctctga tgcaaaaacc gtttcgagcg 3107521 gaatctcagc tctcttgatc cggaatgaca actgcttctt cgttccaggc cgctgaatct 3107581 tcattgaaac gctggaccct ttttttcctc ttatttttaa cacagcgtgg tttaaatcct 3107641 tgccggccat cgattctcca ttgatgctga taatttcatc attaggcttc aacccggctt 3107701 tttccgctgg cgatttcttg aatggagaaa caataataat tttgccgtct tccattccaa 3107761 cctcagcccc gatgccttca aatgaggaat caagagaatc agaaaattgc ttagctgtct 3107821 gcttgtccat gtaaacagaa taaggatcat ttagcgtaga cagcattccc tggatggctc 3107881 cctcgagcag cttttctcta tctacttttt ctacgtactc attcgaaatt aactcatacg 3107941 ctttttcgat tttgtccata gctttatccc gttcagagtc agcttgtgcc gtcgcgggaa 3108001 ctgctgcagt ctggggctta tccatctcaa gcaggttgat tcccgcatat acaccggcgc 3108061 ctccgaacag catgctccct gctgctatca cagccattat tttttgattc atcctttact 3108121 cctcctgtat gccagactgt ctttaccaaa acctagagat agtatatgta aaggatggag 3108181 atttcatgta atcatagaag aaaaagaagg caaatgaaaa gccgtcccga aaacggaacg 3108241 gctttttcac tttatactcg cagaaacttg cggatggaag tcagacttcc ccatactcca 3108301 attactgcgc cgattgcaat cagcactagc gaaacttgga atacaaatgg attataagga 3108361 agaagagaga caaatgatcc ttgaaccttt ggaacgaccc atccgatgac gtattggtaa 3108421 gtgctcagca ccagtgcaat cggaatcaca gaaccgaata cgcctagcag caatccttca 3108481 aggaaaaacg gccagcggat aaaccagttt gtcgcgccga caagcttcat gatttcaatt 3108541 tcttttcttc ttgcgaaaat tgtaatttta atggtgttgg aaattaagaa catcgccgta 3108601 aataccaggc cgataattaa cgcgattccg atgttgcggg aaacgccgac cactttaaac 3108661 aaacggctga cctcttcttt tccataagtg actttataaa catgatccat tttttcgatc 3108721 tttttcgcca cgttcggcgt atcatgcgga tctgtcgttt tgacgacaaa cgcatcatta 3108781 agcgggtttt cctgatcctt cattgtcagg gattttccgc tgtcaccaaa actgtcaacc 3108841 agctggtcaa gctctttttc tttagatgaa aaagtgacac tctgaatgcc cttcagttcc 3108901 ttaatatcgt tctgaagctt gtcctgtgcc ttctgatctg cagtcagatc aatcagcact 3108961 ttgatttcga cttgtttttc tgcattcgtg gccatgttat tcaaattcag cataatcact 3109021 aaaaacacgc cgactaaaat cagcgtaacg gttacagcac taatggatgc aaatgtcatc 3109081 catgtgtttc tcccgagaga tttaaaactc tcacgcaagt ggcgcccgag aattttaatc 3109141 atatgaacca tactcccctc ttgactcatc acgcacaatg ataccatctt cgattgcaat 3109201 gacacgtttc ttcatggtgt ttacgatttc tttattatgt gtcgccatca cgactgttgt 3109261 cccgcggttg ttaatttcct ccagcgtctt catgacttcc caggacgtat ccggatcaag 3109321 gtttcctgtc ggttcatcag caatgacaac atcagggttg ttcacaattg atctggcaat 3109381 agatacacgc tgctgctccc cgcctgaaag ctggtcagga aattgtcgcg ctttatgctt 3109441 cagctgcacg agatcaagca cttcaagcac ccgtttctta atgacagacg gctgttctcc 3109501 aatcacttca agggcaaatg ccacattttc aaaaacagta agtttcggaa gaagcttgaa 3109561 atcctgaaag acaacaccta ttttgcggcg cacgaaagga atctcttttt ctttaattgt 3109621 cgcgagatct ttatgattga ttaaaatttg tccttttgtc ggtttttctt ctctgtaaat 3109681 cattttaata aaagtagatt tacctgctcc gctcggacca acaacataca caaactcgcc 3109741 gggatgaatg gtaacagaaa tcccattgag tgcttttacg ccgttcggat aggctttata 3109801 tacttccttc atctctatca tgaaatcacc taatctttta tatcatttta tctatcacac 3109861 ggtcatactc ttcgaatgca ttcgacaatt tatgacccat tcatttgtaa aaagatgaaa 3109921 aatctgaaag ttcccttttt caatacactt cattatacgt caaatttaga cataatacta 3109981 ttacagtttc ttttcattca tattgtcaag gcataaaaac atccttgcca gcactcggca 3110041 aggatgtttt tatcttactt tttttctgac agccatttgg caataacagc ggcttcgtta 3110101 tcatctacaa gcccctttgg catattgccg cggccgtttt taataatgct ttcaattttg 3110161 tgttcatcgt atttgcctcc gacctcttgg agattaggcc ctgacacacc ttctaaatcc 3110221 ttgccgtggc agcctacgca gctttgctga tataattctt ccccttcaga tgcagtggct 3110281 tccgtcttgc tgccagtgtc tgtcttctct tcttttgcat cgtttgatcc gcaggcagcc 3110341 aacagaacag aaagcgcaaa tccaatcatt agtatcgata actttgattt catgttgaga 3110401 agcacaactc ctttacgatc tcttccatat tataacctcg tttaagcgcg tttgaaaccc 3110461 tcgcccagca cctcgctcgc gtctgctaca attacaaaag ctgactcatc aatctgtttg 3110521 acgatttgtt tcaatttggt gaattcagtt tgcccaacca cgcacattaa aatcggacgg 3110581 tcatcgtcag tatatccgcc gactgcagaa atttttgtca cgcctctgtc aatcttctgt 3110641 aagacagcct ccttgacagc ctgctcctgc tttgtaatga tgagcgccat ttttgaacga 3110701 ttaaagccga cttgcacaac atcaatggtt ttgctggaca catagacgcc aagcatggca 3110761 tataagcctt gctcaatatt aaatacaatc atagccgtaa caacgatcat tccgtcaatg 3110821 atggcgagac acttccccaa tgacagaccg gagtacttat gaatgatctg tgcagccaag 3110881 gctgtacctc ccgtcgaacc tttccctaag tacacaatac caattccgat acctatcccg 3110941 acaccgccaa aaatcgccgc caggagttca tgatgagtgg cgggctgaat atcccttgtc 3111001 agaaacacta ctagcggcaa aaacacagaa cctgcaagcg tctttagtcc aaatttcccg 3111061 ccgagcaaaa tgacgccagc aataaataaa gggatattaa taatccactg tacatacgct 3111121 gcttcaaaac catatgattg taaaatcgta ctgatcccgc tgaccccgcc ggcggcaatc 3111181 ttattcggaa gcaaaaatac attaaaggac acggccgtaa tcgctgctcc tatcaatatg 3111241 tatacataat cccgcaaaat ccacaatgtt ttattccgta cgtccatcat atatcctccg 3111301 tttcttccaa tgctctccga tagcatttta atccttccct gattagatgt aaataacacc 3111361 caaatacagt ggtaatatgc taaagcagca gtgaaatcaa ggatataaga aataaaaaaa 3111421 cacacccgta tgcatcaggt gtgtttttca gcttatgaaa gcttagaacg caggtaggca 3111481 tcaataaacg tatcaatgtc accatccatt acagcttgaa cgttccccat ttctgtattg 3111541 gtccgatggt cttttaccat ggaatacgga tggaatacat aagaacggat ttggctgccc 3111601 cagccgattt ctttttgttc accgcgaatt tcatccagct ctgcctgctg ctcttcaatt 3111661 ctgcgctgat acagcttggc cttcagcatt ttcatggctc tttcacggtt tttaatttgt 3111721 gagcgctccg tttggcatgt cacaactacg ttcgtcggca agtgagtaat ccgaacggct 3111781 gaatccgtcg tattgacgtg ctgtccgccc gcgccgcttg cacggtacgt gtcaacttta 3111841 atatcctccg tacgaatatc aatatcaatt tcatcgttaa attcaggcat gacttcacat 3111901 gaaacgaaag atgtgtggcg gcggcctgat gaatcaaatg gtgagatccg cacaagacga 3111961 tgaacacctt tttctgcttt gagatacccg taagcgttgt gtcctttgat gagcaatgtc 3112021 actgacttga ttcccgcctc gtcacctgga aggtaatcga gagtctctac tttaaagccg 3112081 cggcgctctc cccatcttgt atacattcta agaagcatag agccccagtc ctgtgactct 3112141 gtaccgccag caccagggtg cagttctaaa atcgcgttat ttttatcata cggctcgctg 3112201 agaagaagct gaagctcaaa ctcattgaac tcttttgtta atgactttag ttctttttca 3112261 agctcaagct ggagatcagt gtccggctct tctttcaaaa gatcatgagt catttgtaat 3112321 tcttcgtggg attcattcaa ttttttatac gaattgacat aatcctttaa accgtttgct 3112381 tcatttataa ccgtttgagc tttttgctga tcattccaga attccggatc agccatttgt 3112441 tcatctagct cagcaatgcg ggcctccttt gattcgaggt caaagagacc ccctaaagtc 3112501 cgctaaacga gaagccatat tttcgagctc tgctctaatt tctgataatt ccatttcatt 3112561 cacctcatta aaagatccgc aggcgcctgc aggcgccgcg gtcagtaaac ttgccggggc 3112621 gaactattca gtacggccgc agcaattttt atattttttc ccgcttccgc agtggcatgg 3112681 ggcatttcgt ccgatatcaa ccactttgcg aaccggtgct ttctttgctt ttttgttatc 3112741 gtcgccttct tgcggctgat gagctgttgt ttgaccttgt acaacctctt cacgctccag 3112801 attgttttca atctcagctt tcatcacaaa ttttgcgact tcgtcctcaa ttgattcaat 3112861 catatgctca aacatcgcaa aaccttccat ttgatactca cgaagcgggt tcgtctgcgc 3112921 gtaagcacga aggtgaatcc cttggcggag ctgatccatc gcatcaatat gatccatcca 3112981 tttagaatca acggcacgaa gaacgataac tttttcgaat tcgcgcattt gctctttgcc 3113041 gaattgctct tccttctcat tatattttgt gatgatgcga tccataatga gctcaagcat 3113101 ttcatccggt tctttgccga agatatcgct cttctcaagt gcaccttcat caagataagt 3113161 tgtgttgata agatcaacta gaccgtcaag cttccactcc tcaggaagct cttctcttgg 3113221 cgtataggct gcaattgcgc gttcgagaga agacttgatc atattttcaa cgatttcacg 3113281 caggttttca gagtcaatga cttcaaagcg ctgcttataa atgacctcac gctgctggcg 3113341 gagaacatca tcatattgca gaagctgttt acgcgaatcg aagttattgc cttcgacgcg 3113401 tttttgagac gattcaaccg cgcgagatac cattttgctt tggattggag tagagtcgtc 3113461 catgccgaag cggtcaagca tcgccattgt ccgctcagct ccgaatctgc gcatcaattc 3113521 atcttccata gaaagataaa attgagtaat ccccgggtct ccctgacgtc cggaacgacc 3113581 tcgaagctga ttgtcaatcc ggcgtgattc atgtcgttct gttccgacta cagcgagccc 3113641 gccaagctct tttacacctt cgccaagctt aatgtccgtt ccgcgccccg ccatgttagt 3113701 cgcaatcgta actgcgcctt tttggccggc ctcttcaatg atctgcgctt cacgttcatg 3113761 gtttttggca tttaacactt gatgcggaat tcctttgttt ttaagcagct tagaaatcaa 3113821 ttcagatgtt tcaacggcaa ccgtaccgac tagaacaggc tgtcccgtca tgtaacgctg 3113881 tgcgacatcc tccgcaactg ccttaaactt tccttccatc gtgcggtaaa ttaaatccgg 3113941 gcggtcatca cggacaacag gcctgttggt agggatcgtg acaacctgca tgttgtagat 3114001 gttgcggaat tcttcttcct ctgtcttagc tgtacccgtc ataccggcaa gtttttcgta 3114061 cattcggaag tagttttgga acgtaatcgt cgccaaggtc atgctttcgt tttgaatctc 3114121 aagcccttcc tttgcttcaa tcgcttggtg aagcccctca ctgtagcggc ggcctttcat 3114181 cagacgtccc gtgaaggaat caacaataac aacctgtccg tcttccacta catagtcaac 3114241 gtccttttgc atcgcaacgt gagcttttaa ggcctggttg atatggtggt tgagcgcgac 3114301 atgcttcaca tcaaagaggt tatcgatgcc gaatgctttt tccgccttcg tcattccttc 3114361 ttcagtaagc tgtacagctt ttgttttgat atcgtacgtg taatccttct ccgcttttaa 3114421 cgtgcggaca aaagcatttg cctgtacgta cagcttagtg gattttgcag cttgtccaga 3114481 aatgataagc ggtgttcttg cttcatcaat taaaatagag tcaacttcat ctattaccgc 3114541 aaaatgaagc gggcgctgaa ccatctgctc tttataaaga accatattgt cacgcaaata 3114601 gtcgaagcca agctcgttgt ttgtggagta agtaatatca gcggcataag cttcccgttt 3114661 ttcgtctttt gacattgagt ttaaattcaa accgacagtc aaaccgagaa actcgaaaat 3114721 tttccccatt tgctcagcgt cacggcttgc caagtattcg ttgacagtca cgacgtgtac 3114781 gcctttaccg gttaacgcat ttaaataaac aggcagggta gacgttaatg ttttcccttc 3114841 ccctgttttc atttccgcta tatttccgtc atgaagcgcc acgcccccca tgagctggac 3114901 tttaaacgga aacatgcctg ttacgcggcg tgaagcttct cgaacaacag cgaaagcttc 3114961 aacaagaaga tcatccgttg tcgccccttt ttcaagacgc tctttaaatt caattgtttt 3115021 atgtttcaat gcgtcgtcag agagattttc atagtctccg cgaatcgcat caatatcgtt 3115081 agcaattttt tcgtatctat tcagcgtacg ttttgttgga tcaaacattt tatttaaaat 3115141 tccaagcatt tataacgctc ctctatcatc acacgcctat tttagaggca tgtataaata 3115201 atttactagt ccatgtatac ctctcattat catatcatac cttttgttat ttccaaagaa 3115261 tttgcaaata agaaaaacaa aaaccttccg cggacatcac ggaaggcttc tcttcattat 3115321 tcagtcggtt caattaagcc atatttcccg tcatttctgc ggtacacgac atttgtaagg 3115381 tttgtttccg catttgtgaa aacaaagaaa ttatggccga gcatattcat ttgcaagatc 3115441 gcttcttcac tatccatcgg ctttaaatta aagcgtttct gacggacgat gtccaagctc 3115501 tcctcctctt ctatgtcatc ctgaaccgca atatctgtat cagagccaag accgtttgcc 3115561 aataaatatt ttggagagcc ctgctcacgg aatttacggt ttactttcgt tttatgctta 3115621 cggatttgac gttccagttt gtttgttgcg agatcaattg cgttgtacat atcctcgtta 3115681 tgcacctcgg accgaagcgc cagatctgtc atcggaatcg taacctcaac cttagactcc 3115741 ttgtcattgt aaaacttcaa gttgacgttc acatcagcat ccacgctatg gtcaaaatag 3115801 cgctccagct tgccgatctt cctctcgaca tgatccttta acgcgggtgt cacttcaata 3115861 ttttctcctc tgatgttata gttcatcaaa gaacgcctcc cttttattaa ggatatgtat 3115921 ctatttctct tttacccttt acaattcctg ctgaaacata aatcttttgt gaaaattcag 3115981 tgaactttgt cgaattttgt ttgtatttgc tctgttattg gcggttcgga ggtatatgta 3116041 tatgctgatt gaacgaaaca aatacctcac acacgcctaa ttgattaaaa agggttccat 3116101 acattgatga atagacagca tccattttct ataatgaatc agaaaatgtt cctttaaata 3116161 ctcacagaac tcatgagagg gaaaagagaa agagaccaat tgatcaaact ccgcaaaaat 3116221 ttggtcaaat gctttcacac aaatttcagc acaccgcgaa tccataatga agagaagtgt 3116281 tgaatgtgtt gaatccaaat aaaaaaaggc ttggatcaga tcttggtaga tccgatcccc 3116341 ttctgttttt gataaattct cttcagcctc tatcaaataa cacaacccct cttcgatggt 3116401 aaaaagaaga tgataataag ctgataaaag cgtataatct tcaatgctct tcaaggcact 3116461 cacctattta cgcttgtcat aatatgtgcc gtcaatcgta atgttgttat aagggtttaa 3116521 atacgtcgta tgcatcacac gttttctttt catctgctga agttctgttg cgattgactg 3116581 cttcagtctt tccatttcct tcacaatcag ctgatcccat gtcaaaataa gtttcatctg 3116641 ctttcgctct tcttctgaaa gcggcagaga tatctcctga atcagttcag accgtgtagc 3116701 cacaaagtct tcaatttgct ttaaaagttc atcgctttcc ggcgtatttt gtatgtgtga 3116761 cagcatactc ttcgtctcag tgtatagttg atctatatta ttcatgcgat cccgcctgat 3116821 ccgtgccggt ccttccgctc actttgaatg gcttgtttcc aagcatcgcg aaaatctgtt 3116881 acataacctt caacctcagc cagcatgccc gtatcatttt tgatatttgc ctgtaccaat 3116941 ctgcgataca tataatcgta catcgcaccc atagaagcgg aaagctctat gttacggtta 3117001 agtgtaaaat ttaattcctg aataatattt tgcgctttaa tcagattttc atttttacgt 3117061 tccatatcat cattctcaat ggcctgagcg gcaagtctta taaatttcaa acagccatta 3117121 tacagcataa gcgtcagctc cccgggtgta gccgtattca ctgaattttg ctgataggct 3117181 gtatatggat tttggatcgc catgtgtcat cctccaaatt acatttattg tacaagaagc 3117241 tgtgataaat aggacgcttg ttcgttcatt ttttgaatcg cagaatccat tgcactgaat 3117301 tttgaataat agcggttttc tatggtattc aatctgtcct gcatatcagt tatttcagta 3117361 cttatcgagt ttaaattttt tccaatggaa tagctactag ctcccattgt cgagttccca 3117421 gctttagctt caatactttt cacagtactt ctaagtgtat tagtaatccg cttcataata 3117481 cctttatcgc tatagttact atcatttgtt ccacttgtaa aaagattagc aactccttga 3117541 ggatcttctg ctatttttgc tttcaatttc tcttcgttaa tctctaagtg ccctcgcagt 3117601 tggtaagcac ttgaagttgt gatgccaaat tcagttaatt gataggtttt cccatccgca 3117661 ttcacttgag tataaaagtc agtccgcatt tggttcgtgc cagtgctgat gcttgaatcg 3117721 tttctcagca atccgctttt cgccttctcc tcccagagct ctacctcttt atcggacatg 3117781 gcttcttttt gttcactcgt gagtggcgta tagtctcggt atttttcttc tttcagcttt 3117841 tcattcaggc tgtcaaccag ttcattgtat ttatctacaa actctttgat ttggttataa 3117901 atcccatcaa catcagtaga aacagatgtg gtaacagggc ctgtggctgc agttgtattt 3117961 ttaatcgaat aagtaacacc attcaccgtg aaattgtttg tcagcttctc catttcaaag 3118021 ccgttgattg tgactttggc atttgtgcct tctttgtaag cagtaagctt attatcagca 3118081 tccaaagaaa aaccaagctg accggacata aagtcagctg tagcagagtc tgctgcctgt 3118141 atgcttcctc ctgcacctgt tgctttagaa gaaaacgcaa tcgtttctac gtactctgta 3118201 ccattccaaa ttttatcttt aaatgctgat actcctagat ctgagctgtt aagtttagaa 3118261 atcacattat caatcgtatc ggcactcgtc acactaatgt tcactgtttt tgctgttgtt 3118321 tcgccaggcg caacaacgtt aaatgccaaa ttgtaatcgc cttgtgtgta tcccgtataa 3118381 ttgtttgcct tatacgttgc tgcagttgcc aagctcgcca cttcaacagt agacgaagaa 3118441 tttggcgcac ttacgcttcc tgtagcagtt aacacagact cattagagct tgtcacagtt 3118501 ttgctctgat acgtgctcgg atatgtcaac gtatttttag acatataatc ttgcaattct 3118561 tttatttttg agtttacttc acgatagctg tcacgctgcc attcaagagt ctgctttttt 3118621 tgtgtcagct tatcaagcgg cgctctttct gtctgcatca gctttgatac gatatcatct 3118681 atatccattc ctgacgccag acctgttatt cttgtgacca tctcaaacca ctcctattct 3118741 actttttttc atctacaaat aacccaagaa attcagtcat agccgcataa aaatcaagcc 3118801 accgttttgg tggaatttcg cggatcactt catttgtaga gtcctctatt acctttacat 3118861 agtattcatt taacttgtca tgaagctcga acttcagatg aacttgcgaa ggttccaaaa 3118921 gcttgttcat ttcccccacc atttcagcaa gattggtata tgaaacttga tgaacaggaa 3118981 cctcgttatc attatctttc tgattatgta tttgagtatc ataacgatcc caaacaggtt 3119041 gtaacgtagt gagcctttca atgttcaatt gatcatcccc tatgccccaa tctatcgttt 3119101 atatcgacta agtcgagata agattacaca tatttttgga aaaaaatctt ctgttttaga 3119161 tttcttgtat ggaaatacat ttataaaaag ttagtggaga atccggttat tatatcatga 3119221 gttagtgaca ggatgaggaa tgattaggag atagaaattt aaattaaaag accctggcaa 3119281 cgccaaggtc ttttttaaaa ttaacgtaat aattgaagta cgttttgcgg ctgttggttt 3119341 gcttgagcaa gcatagcttg agaagcctga gaaagaatgt tgttctttgt gaattcgctc 3119401 atctctttag ccatgtcaac gtcacggata cgagactcag cagctgtcaa gttttcacca 3119461 gaagcgctta agttgttaat tgtgtgctct agacgatttt gtaccgcacc aagcttagca 3119521 cgttgagaag aaacttggtt gatcgcttca tcaacaactt tcaattgagc atcgaaaccg 3119581 atatcagcag tatctgctgc attatctgcg aattttgtta cgtcaagatc attaactgaa 3119641 tgaagagctg caattgaacc atcagcttct ttaattccaa gagcgtcagc acccatatcc 3119701 tcaatattta cagagatttg ctgtgtagca tttgctccga tttggaatac caagttcttt 3119761 tgatttgcag gagtagctgt gtcaactttg taagtgccat cgagcaattt cttaccattg 3119821 aattctgtac gatttgaaat accatcgatt tcatctgtta aagctgaaat ttcatcttga 3119881 atagattgca aatcagttgc tttgtcctga gttccagtgt ttccagcttg aacaactagc 3119941 tcacgaacac gttgaaggat cgcatgagtt tcagttaatg caccctcagc tgtttggata 3120001 agagagattc cgtcttgaga gtttttagaa gccatttcaa gacctctgat ttgtcctctc 3120061 attttttcag agatcgcaag acctgctgcg tcatctcccg cacggttgat gcgaagacct 3120121 gaagaaagtt tctccatgtt cttttggctc gcactgttgt ttgaagacaa acggttcagt 3120181 gtgttaagcg ctgcaatatt gtggttaatt ctcattgttt tgttcctccc tgaatatgtt 3120241 gttaaggcac gtccttgtgc ccttattttg taactggctg agtcttttgc gcctcctccc 3120301 ggctacatca ttaatatcgg attgtctctg attttgttaa tacaaaaata aaaaaatcct 3120361 cacttttttt gtgaggataa tgcggagatc acatcgctgg ataacgctgc tgcacggtta 3120421 ttttcttcct gaatggtcaa gtaaatttct ttcctgtgaa tatcaatatg ctttggggcg 3120481 tcaattccaa gcttcacttg atccccttca accgcaatca cttttacttc aatatcagca 3120541 cctatttgaa tcgcttcgtt tattttccgc gataaaacta gcatgattct cctccaatcg 3120601 gatgctttgt cgtatatgag gagtcgtgta aaacgacttg cttagccatc atgttcttgc 3120661 gattcacaat aatgggagcc aataaattcg cagtagactt ttcaaatggc tctgccatag 3120721 tcaatattgt catgacttct acgtcttgaa tattatcgat atccaaaagt tcagcagttg 3120781 attcatcaag atcaaattca taattcttaa aaaagataaa cggacttacg acgataaacg 3120841 caagattttc tgaagtgacg gactgcagtg ccacgaatgg agagtcttct gaaagcggaa 3120901 gtatgacgaa ctgtttttct tctaaaaagc ctggaatccc gctttcaaaa agaatgattt 3120961 gttcttcttt tatgttcatt tggccatggt acttcgtatg aatgatcatt gttcacgatc 3121021 cttttctttt tacttttcgg gtgattcttt cgggtattct acatctatat ttaaatcagg 3121081 gtattgaagc atgtcaacct taacatttcc tggcgtatat tcaacaattg gcttatgcgg 3121141 ctcagcctga ataacaggct ttcgcggcgt aatctgcaca tcaagctgtg acggagtata 3121201 ttgtattttc accctcgaaa gagaaggagc ataattttcg cctaattgaa tttggtgcat 3121261 ttcagagttc ctccttgctt gtgaagcgat tgggttcccc ttattttcaa tcttcataag 3121321 ctcgtcgcct tcttctgcag tgcgtgctat tccctccatt acatcctcat gcccttgttg 3121381 ggcggcttct tcaattctct tgaaaacatg ctttctgtct aattcttccc atgcttgtgt 3121441 ctggtcaatc gtgagttttc caggtgtcac cgatatttcc atttccgcac tcggctgttc 3121501 gatctctaga tcagcttgag gctgctccat ttttaagctg gcaggcgtcg ttgttaaacc 3121561 aatttttcct tgaacactat gcataatcaa tctgggaatc tgcatcactc tacctcctga 3121621 actataaaaa aagcgaactc ctaagagccg cttactttaa aaagtcaatc aatgtaggct 3121681 gaacaatttg cgcattaacg gccagagtag ccctgtgcac actttgctgc gcaataaatt 3121741 cagttattac ttcttccagt tctacatctt cattgtctga taacactttg gtagctgttt 3121801 cttcttgcgc tgacagtctt gtattaacca gttcaagacg attatatctc gctccaagat 3121861 cagatcgttc agcgctcatg ccgtcagaaa aatgatcaat atcatttaaa acactgtcca 3121921 tgccatctag cgaaccagaa tttagtgctt tctcaaaaga atcaagcatt tcaaatacat 3121981 tctgcccgct ttcagaagtg cctccaaaag ctgactttgg atctgaattc actttcaatg 3122041 acatattatt tgatatattg actacgacat cagctgtatc agaaattgta taagttccgt 3122101 ctccgttatc tgtaaccgga ggcttatctg aatttgtgcc attaaagata tatctgccgt 3122161 tcacttgtgt attcgcaata tttaaaagct gttcctttaa ctgctttacc tctacgccaa 3122221 tcgcttgccg ctccggctcg ccgtttgtat cattttgagc ttcaaccgct aattctctga 3122281 cctttgacaa gatgtcaatt ccttctgtaa tgtttgtttc tgtgttttcg agccaggtaa 3122341 aggcttgaga agcattgctt ttgtactgct gcacttgaga cagttgcgta ttatacttta 3122401 agcttttcat tgctactaca ggatcgtcgg aagcttttga gatttttttt cctgaagaaa 3122461 tctgcgactg gagtttatcc agcttcgagt agcttgaacc gatatatctc agtgagtttt 3122521 gctgtatcat gccttgtgtt actctcatgt gactctacct accttcctcc aacacccatg 3122581 ccgttgatca ctttatcaag caattcgtct tgtaaagtca ccattcttgc agctgcattg 3122641 tatgcgtgtt ggaattgaat catattcgtc atttcttcgt ctaaagaaac tgcgctcatt 3122701 tgctgacggt ttatgtcagc atcattcagc tgtgtttctg tattagacgc cagtcgatta 3122761 gcctcttgag cttcgatccc tagctcgcca atcagacccg cataataatc taaaacacta 3122821 gtttctttac cgttaatggt tattttaccg gttaaaacat ttgctaattt tgtagcattt 3122881 gcgttatcgt tggctgcgcc agtcagtgag aaagcaatgt ttgcgccttt tgaatctatt 3122941 atgctgtcag ccactttgat cttgcccgcc gcgcccttgg caggttcagt ttcaccgcca 3123001 gtaaaatcaa aaaagtctcc gccttgttca ccgctcttgg tcacaccatt tctgtgcact 3123061 tcattgaaag ctttcgcgaa ttcaagcgcc atattgtcaa gatcagaaag catttccggg 3123121 tatacgccct tttcttggcc atctgctgtt atatacccat aagactctat aaaccctaaa 3123181 agggatccct tgctgctaaa ggactccgcc tgtacagctg tatccccgat tgaaatactt 3123241 gatactaacc cagtttcatt atcatagttg gctgcaagtt ctgaaacctc gtaattttta 3123301 ccgtccaaaa cagttcctag cgactgttta tttttatcaa ggatttcaat tgatacagtt 3123361 ccttcagcag atgcaagtgc attcccgcct gatttgttgt agctgacttt gatatcaacc 3123421 attgaggata atttatcgat cagcaaatct cgctggtcat ataagccatt cggaagaagc 3123481 ccgaccggct ctacttgtgc aatttgctta tttaaactgt ttaactgaga aagcagagaa 3123541 ttgacatcca acacagttgt atttagctct gcttttaaat tcgattggac atttgtaagt 3123601 gattcagaaa tataattaaa cgtttcagct acagcttgtc cttttcgagc aacaacagaa 3123661 cgtgcacttt cttcatttgt attattcgat aattcctgca gggaattcca aaacgaattg 3123721 agcacactgt tcaagccgct gtcatccgtt tcatttaaaa cgccttccat ttgggacagc 3123781 gcttttgcct tcgtgtcata gtatccggca ctgttgtttt gaagacggta ttggtagtca 3123841 agaaagatat ctcttattct ctcaactgat tttccttgaa cgcccgtacc catttgtccc 3123901 gctgtttttt ctgcattttt agatacagca gggaaatagt cagttgcctc caatgagacc 3123961 cgctgtcttg tataaccatc agtattggca tttgccacgt tatttgcagt agtgcttaac 3124021 gctgcctgct gagcgcttaa cgcccgcctt gcagtttcaa gccccataaa ggtagatgtc 3124081 attttctgaa ttcctttctg ctaagctttt gaatcaaaca gtttcatttt gctacttttc 3124141 ggcagctcag ctttaattga tttgctgtaa ttgaagttat tttccttagg aaccagcata 3124201 tcgtacgaaa tagagatgaa ttgcagcgcg tctcttgtca gctgcctatt catctcattt 3124261 acttttttca gacgtccgag aacttgagaa agagattcgt atagttgttc cagctcttcc 3124321 ttttcactgc ctgaggtttt ggcgatacat gcggaaatag tattattttc gctatatccg 3124381 agaaaggccg aagttgtttt gatccggtca tcttctgtct gcgtgattgc ttgaatatat 3124441 ttttgctctt ttgtcaaaat gttagaaagc tcttttgttt tgccggcttt gagcgcttcc 3124501 gtcttttctt cagacagcgt gagcaggtgc tcatgcagaa cgcaaagtcg cttcaattgt 3124561 tcaataattg ccttcgctga catgggcttt ctcctttttt attgcttttt ataaaaatta 3124621 atcatatttt tcgcaatatg atttgcgtct actttgtatg acccgttttc aatttgcgct 3124681 ttaagctgcg caattttttc ctgtcgtgaa ccagtgactg cgtcggatgc atgttgcatt 3124741 tctttagcct gtgatgaaat ttcaatttta tcttgaggtt gtgcaacagt tttttgcacc 3124801 gcttgcttat cataattttt ttgatatgga ttaacggatt gtgttccaaa ttgattgatt 3124861 ttcataggat tcctctcgct ttccgttgca gtctttaaac aatcttaacc cttttatcga 3124921 ctgcgttttc agttagttta gggaatcagc tgtttttggt attataggca tagtatgtgt 3124981 cttttttact attttctttc tcgattttca gagcatcctc gtggttcaaa tgatccattt 3125041 gatccttaat atcagactgg caagccttgc agaacttgcc ttctctaatc gatgtcccgc 3125101 acctttcaca agggtatgcc aaattaggaa gatgagtgat ctgaattcgc ttctgcctga 3125161 tgaatttcaa tatcagctct tcttccacac ctgtttcctc agttatccgg ctcaaagttg 3125221 attgccggtt ttcctgtttt cttaaaaatt tatagacagt ctcaaatgat ttttcttctt 3125281 ccttaataca cgcctgacat acggtttgca gctttgtttt taaaaataaa gcattgcatt 3125341 tcggacaatt agccagttct cccatctttt tttctcctta ttagataata tgcctgtgtc 3125401 aatttctagt gattatatcg gcataaaaac agaatcattt agcttctgat caaggtaaaa 3125461 gatgacactg aagcggcttt tcctttttct aataagcagc gggctgcgaa gtgcaaggtg 3125521 gcgcctgttg tataaagatc gtctattaaa atgatattca taccttctgc tgaattattt 3125581 tttgtatcaa aaatgcactc tgacagcagg cgttctgttt tctttttctt tgactgtttc 3125641 tcattattca ggcgaatgag gggatggtgg gaaggccggt ctaaacattc tgccaagaga 3125701 tgtgcctggt taaatccgcg ctcttcttcc cgttccttgc tcagcggaat aggtacaaga 3125761 acaaaatgct tatcggggta aaccttagaa aaggttgaag aaaaatcact tttaaatgca 3125821 tttatgattt ctgcatctcc tctaaattta aaacgggaga gcgtttcttt catcatatca 3125881 ttatatgtgt aaactgaacg gttttgacgc aatagcaaac tgtctctgat ccttgttctc 3125941 cacacctcgc aatccctgca tacggcatga acagattgag gtctgccgca cagggggcag 3126001 atatgtcctg tgattttctt taatttgctt ctgcaagaat aacaaacctt ttcatcaggc 3126061 tttagtaaaa aaagggctct ccatgtaaca tcttgagaaa attgcgaatc acataataaa 3126121 cagatcagtt tatgaatgcc tcctcctgct tcgtttgaca taaatcgctt ggactctctg 3126181 aaactactgc agcagattca gccaaaatga caagcattgc tgtgtttttt tgtttatcta 3126241 ccagctcagc tttcgtatat gcgatctttt taaaatcagt aacgtaggat ggactcactt 3126301 tgtttaaaga aagtgccaat acatcgtttt ggcatacttg gcaagtacag gccatatgaa 3126361 gctggtccat atatcggtcg agcagttctt tcattacgat ttcttttgaa ttgacaagca 3126421 tttttacagc tcctcatcat cggttatatg agtatactgt accacgtttt caaataatgg 3126481 ctagtctgta cattcaactt ttgctgccaa ttcattcatt tcttttatat gctttcttgc 3126541 atcgagcata ctctttgttt tgccgaagtg aaagtaaatg acatcgccgt ccgcatattc 3126601 tttatgccgg ccggttcttc ctgcaatttg aacaagtgcg ctttccgtaa agatagacga 3126661 ttccgctcct agtacacccg tttgcacctt ggggactgtg acgcctcttt ccagtattgt 3126721 tgttgtgatt aatagatcga gctgaccatc tctgaattgc tgcactttct cctttctatg 3126781 cttgtcttcc gcgtgcacag atgcggttcg gcaatgaaca cctttaaagc acgcagcagc 3126841 cttttccaga atagaaacgg aaggaacgaa taaaaaaaca ggcctccctt cttttacatg 3126901 aaactctatc catcttttca ccgctggcgg aattttattt cggtttaatt tcttcttcca 3126961 gtttccacac catacaaagc gcggttcggg taaaggtttc cggtggtgtc ttgcggggat 3127021 gcgaactgaa tgtaactgtc cgttcagtgc ttttcttttt aattctttag gaggtgttgc 3127081 acttaaataa acgagggtgc tgtttttctt tcttgctttt tgaacagcga attgaagggt 3127141 ttgatcagca gaatatggaa aagcgtcaac ttcatcaatg atcataacat cgattgcatc 3127201 tttatatcgc aaaagctgat gcgtagtgga aatcataagc ggagatagcc gccctttgtc 3127261 atcgcttcct ccgtaaagcg ctgaaatgtc agcaccctga aaggcagcct tgagtcttgg 3127321 agcaagctct aatacaacat cggtgcgagg tgttgcaata catacacgca gtccttgatt 3127381 taacgctgat tctataccag gaaacagcat ttctgttttg ccagcgccgc aaaccgccca 3127441 gatgaggagc tcttcttttt ttgatattgc ttcaattaaa acattggcgg ctttttgctg 3127501 tccgcttgaa agcttgccat cccatgtcag cttaatagac ttccagtttg attcattttc 3127561 ctctttccat gaatataaag gaacctcctc actcactctg cccatcatga cacaggaacg 3127621 gcaatacagc ttattctttc cagatgagtg ataaaaagaa aaataccgct gatcagtttg 3127681 tccgcaccta ttacatctat atctccgttt atttatggat atagaatttt cagcagtgat 3127741 atatccattc ttgatatgcc attcaatcat ctcatcggaa aatgagagct cagtcctgag 3127801 caaatgacgg cttcgaagcg tctgctgcaa ttcttttgaa aaggaactgt ttttttcaac 3127861 tggcacattc acatagcacg cctcctttcg aaacagtatg cctgaatgaa tattttctgt 3127921 ccaactatta aaataagaat ataaaaaaat ctccgctcta aaaacggaga tttggcctta 3127981 tttaaaacac cagcaaattc ctaacgcacc ttcacccaaa tgagtgccga ttaccgcgcc 3128041 aaaatagctg ttataaaatt caacatgagg atattttgca gaaagctctt caatgatttt 3128101 cgctgcttct tcctctcgat tagcgtggat aacagcagct cgcataggca accctttact 3128161 cgcatcttcg tctaaaagct cataaattcg cgaaattgct tttttacgtg tgcgaatctt 3128221 ctcaaaaggc acaattacct tattgtcaaa atgaaggata ggctttacct ttagaagact 3128281 accaatgaag gcttgggcgc tgcttaatcg cccgccgcgc tgaagatggg ctaagtcatc 3128341 taccataaaa taagctcgaa ctgttttttt catttcttcc agttctttta taatatcttc 3128401 cggcgatgat gctccgtttt tgattaattc agcagcttta agggcataaa agccttgagc 3128461 caagcagctg atctctgagt caaatggata cacatcaata ttgtcgacca tcgaatcagc 3128521 cgctgctgca ctgctgaatg ttccgctgat cccgctggaa agatggatac tgataaccgc 3128581 atcataagac ttgccaagct cttcatacaa cgcaaccagc tcgccgattg gcggctgaga 3128641 agtcgtcggg agctcattat gttttttcac ttcttcataa aagcttttcc agtccaactc 3128701 aatttcttca cggtaagtct cctccctaaa aacaacctgg agagggatca tatgtatctg 3128761 atgttgttca cgcatttctt tcggaatata tgccgtgctg tctgttacga ctgcaatatt 3128821 catagcttcg atacctgcct tattgcttta taactctatt gtaagggaaa cggcagccta 3128881 aaaaaagacc tgcctagtaa aaggcaagtc tcctattata ctatctcatt tctacccagc 3128941 catttttaat ggcgaccaca acggcttgcg tccggtcgtt tacattcatt ttttgtaaaa 3129001 tattgctgac atggttttta acggttttct cactgataaa caatgattca ccaataccgc 3129061 ggttgctttt tccgtctgca agcatctgca gcacttcaca ttcccgccta gttaaaatat 3129121 gtaatggtct gcggatttca gggtaaacct catgttgagg gtgtgcagaa actccgcttg 3129181 ttgcaaggcg gcggaattcg ttaacgaggt tgtgagtaac cttcggatgg aggtaagatc 3129241 cgccctcagc cactacttta accgcttcaa ttaatgtatc agcatccatc tctttcagca 3129301 gataacctct tgcacctgtt ttcagggcat gtgttacata attttcgtca tcgtgaattg 3129361 atagaataat tactttagat tcaggataca gctctacaag ctgttttgta gcttccacac 3129421 catttacgtt tggcatattg atatccatga tcacaacatc aggatgatag tgctcaacaa 3129481 tacgagccgc ttcgtccccg tcatcacctt cggctaccac ttcaaaggta ggttcaaaat 3129541 ccaatatccg tttaacacct tcacgaaata actgatggtc gtcgataata acaatgttta 3129601 ctttagtcac aagccacgcc tccttgtatt attgttctat atactctagc attcggtcaa 3129661 tatgcctttt ggctctattt tacaaatcat agtcaaagag ataacggaac cttaatcata 3129721 ataaatgtcc caagacctat tttcgaatct attgtcatcg ttccttccaa taaatctact 3129781 ctttctttca tgcccagcaa gccgaatgat ttgtttttct tctctttcgc ttccttcagg 3129841 tcgaaccctt taccgttatc ttttatcatt aaaatcacaa aatcctttgt gatctcaact 3129901 ttgactgtaa tttcttcaga ttcagaatgc tttagcgcat tagacacagc ttcctgtgcg 3129961 agcctgaaga gcgcaacctc aaactgaggc gctagcctct gatcctctgt ttctccaatg 3130021 cactgaaaat gtattttgac cttcccgtta tattcctcgg ttgtatatag atattttctt 3130081 aaagttggaa tcaggcctag gtcatcaagg gccatcggtc ttaaatcata tataatcctt 3130141 ctcacttcgt aaagggcatt ccgaacattt tggcggagat ttttaatttc ttggaatccg 3130201 tcctctgcgc cccggtcacg gaaaatccgc tcgattaatt ccgatctcat cataacattc 3130261 gccagcattt gagcgggtcc gtcatggatt tctcttgaga ctctttttcg ctcttcttcc 3130321 tgcgcctcaa taattcttaa gccgaaatcc tgttttgcct gagcatcagc aagaagcagt 3130381 ccaacttcgc gcaaatcctg attcaagtag ttgagcacaa ctgtaatttg gcttactaat 3130441 gattctgacc gctcaatgat ttcctgaagc cctagcaatc tgcgctccaa atcgtcccgc 3130501 cgttcgcgca attgcttctc acgctgctgg atcatcgtca attctacctg cagcttatgg 3130561 gctttttcat aagcattgcg gatttcctct tcactgaatc tatgaaaatt acggctgacc 3130621 tcggataaac ggtttctcgc atggcgagtt tgcacttcaa gtttatcgcc aagctcaatc 3130681 acttcataca cctgctgttt aatttgtttc agttcttcga ccagctgttc atactgctgg 3130741 cgtgactgct ccccgatttg aaaaacctcg tccttgctcc cgtcaacggt tttcagcatc 3130801 ttcatcaaaa tagaatccag cactttggaa tccatctttg ttttattcat aatttccctc 3130861 cgtcacggcg ttgtcatata tttttattat aaatgtaatt gatctgcaaa ttatgtcgaa 3130921 ttataatgaa agaatgcgta tattctagaa aaaaacattt ttatatacta tctactcttt 3130981 atgataccaa aatacgcaca aaaattctaa agactgtacg aatttgtata ggcagtcttt 3131041 tatgcttagc aggagggtca gctagcatgc tgcacagcta ttttactgtg aaagaagcgg 3131101 gagaacacga gattgttata gaaaaatcgc gttttatctg tcatttaagc cgtgtttcta 3131161 ccgaacaaga ggcacaggaa tttatacaga aaataaagaa acagcactgg aatgcgactc 3131221 ataattgctc ggcttatgtt attggcgaga atgatcatat ccaaaaagcc aatgatgacg 3131281 gggaaccaag cggtacagcg ggagtgccga tgctcgaggt tttaaaaaaa cgcaggctga 3131341 aggatacttg cgccgtcgtt acacgctact tcggaggcat taagcttggt gctggcggat 3131401 taattcgcgc ttatgggaaa tcagtgtctg aaggattaaa tcatataggt gttgtagaac 3131461 ggaagcttat gcgaatcatg catacttctg cagattacac atggcttggc aagattgaaa 3131521 atgaattaag ggagtcacaa tttctgttaa aggaaatcca ttattcagaa aatgttgaat 3131581 tcgaaacata cgtggaagaa aaagaaacca acgctttttc tgaatggatg acagaactga 3131641 caaatggaaa gagtgatatt aaagagggag agttgacgta tcttgaaaaa gccgtcaatc 3131701 acataaagga gactgaataa tggctgaacg cgttagagtg cgtgtgcgaa aaaagaaaaa 3131761 gagcaaacgt aggaaaattt taaaaagaat aatgttattg ttcgcccttg cactattggt 3131821 agttgtaggg cttggcgggt ataaacttta taaaaccatt aacgctgcgg atgaatcgta 3131881 cgatgcccta tcccgcggga ataaatcaaa tcttcgcaac gaagttgtag acatgaagaa 3131941 aaaaccattt tctattttat ttatgggaat agaggattac gcgactaaag gacaaaaagg 3132001 gagatcagac tctcttattg ttgttaccct ggatcccaaa aataaaacca tgaaaatgct 3132061 gagcattccg cgtgacacac gtgtgcaatt agctggtgac acaacgggaa gcaagacgaa 3132121 gatcaatgcc gcttacagca aaggcggtaa agatgaaaca gttgaaactg ttgaaaactt 3132181 cttgcaaatc ccgatcgata aatatgtcac agttgatttt gacggattta aagatgtgat 3132241 taatgaagtc ggcggtattg atgttgacgt gcctttcgat ttcgatgaaa aaagtgatgt 3132301 agacgaaagc aaacggattt acttcaaaaa aggcgagatg catttgaacg gcgaagaagc 3132361 cttagcatat gcccggatga gaaaacagga taaacgcgga gactttggcc gtaatgacag 3132421 acaaaaacaa atcttaaacg cgctgattga ccgcatgtca agtgcaagca acattgctaa 3132481 aattgataaa atcgcagaaa aagccagcga aaacgttgaa accaatattc gcattactga 3132541 aggtttagcg cttcagcaga tttacagcgg ctttaccagc aaaaaaatcg acacattgag 3132601 cattacaggt tctgatttgt atttagggcc taacaacaca tattactttg aacctgatgc 3132661 tacaaatctc gagaaagtca gaaaaacgct tcaagagcat ttagattata ctcctgatac 3132721 aagcactggc acttccggta ccgaagacgg gactgacagc tcaagcagtt ctggcagcac 3132781 tggcagcact ggcacaacaa ctgacgggac gacgaacgga agcagctatt cgaatgacag 3132841 cagcacaagc tcaaacaaca gtacaacgaa ttcaacaact gattcatcct attaaaaaat 3132901 gcccggtcct tttagaggat cgggcatttt tgcgcagaaa aaaactccgg cacataagcc 3132961 ggagttttta attccttttc accagccgtt tataaaactt tgtaaacggc ttaaattttt 3133021 cattcacgag tcctgtcact tctgctatga tttgcataaa aataatcaaa atgaagataa 3133081 taaacaaaga aagccaaatt gtggcacttt taagtacaat cgcactgata ctgaaaataa 3133141 atccaattaa ataaataact aagaccgaca tccgatgtga aaggccaaag gccatcagtc 3133201 tatggtgaat atgcgactta tcaggcgctg aaatcggctg tttgtttaat attcttctga 3133261 tgatagcaaa tgttgtatca aaaatcggta cgcctaatat aataatcggg ataacgatac 3133321 tgaacaatgt gacactttta tacaggccta ataatgaaag aatcgagata ctatacccta 3133381 aaaacagtga tcccgtatct cccataaaga tttttgccgg atggaagttg taaaacaaaa 3133441 accccagcgt gctggcaata acgactaatg agagtgacag aatgagcact tttccgccgg 3133501 atagcgccat gacagcaatc gttgacaggc cgataacaga aagaccggca gcaaggccat 3133561 ccaatccatc aatcaggtta attgcgttcg tgatgccgac aatccataat accgtcagcg 3133621 gataagccat ccatcctaac tcaaatcgtt ctgttaaaaa aggtactgag aaaaagtcca 3133681 tttttaagcc agtgcttaca atcataatgg ctacacctaa ttgaatcaaa aacttaactt 3133741 ttgcacttaa ttgatattta tcgtcaagaa tacctaacac aataatgatg aatgctccga 3133801 ctgtaattgc cgtcatcctt gtttctgtgt aaataccgga tgcaagcacg cctgcaacca 3133861 ccccgataaa tatggccagc ccgcccatgc ggggcatgat tttgtcatgt acttttcgat 3133921 tgctgggctg gtcaactgca cctattttaa tcgcaatcct ttttacgatt ggggttatga 3133981 ttaaaactgt cagcagcgag acaataaacg caacaacaat gcgaatcatg cgttcgtcaa 3134041 gcataaagaa gtctcctttg gaattaaatg aagtctttat ttatatagag aaccgttcct 3134101 tccattatac cttctcctta gttattataa caagcttcat caaaaagaaa cacgtataat 3134161 caaaaaacgc gcatcccaat ttataggact acgcatgttt ttgaatccct gtatatttca 3134221 taatttgtct aaataagcaa ttccaatctt gtgtccgggc gatgtttcgg cgcatttctt 3134281 tataggtctc gtctccgttt tgaccgagaa ctttttcaca agcggctata aaatcaatcg 3134341 gatgatcgcc ctctacatat tcgtatacat acggcttttg catttttgag gttgacggaa 3134401 gattagtgcc tacaacaggt tttcctgccg ctaaaaattc aaatagtttc agcggaaaca 3134461 cagcttgatt atacggtgat tgtttatatg gcataatgcc aatgtcgata agctccatat 3134521 aatgaggcac ttcttttgga tctgccggac cggtccatat gacattggga agcctcagca 3134581 gctcttgaaa cgaaacatca ccattggtgg catccgggcc aacccataaa aatgtccaat 3134641 caggcttttg cagtgccgct tctttaatca ttttaaaatc gagcttcggt ttaatcccgc 3134701 caataaaacc taacactatt ccttctctcc cctgcagtat actgcgatcg ggagcttgtt 3134761 tatttgcaga aaacagctca tactccacac cgttttccac agtatgaacc ttttctcgtc 3134821 ctgcagtcag ttttttgtct acttccttgt gaagataatc tgatgaacag gttattgaat 3134881 ctgctcgttg tataattctc agctctgccg atttaatgac ttttcgccgg aattcagaca 3134941 gcagatttga tcggccgctg atcggcgcag cccataggtc actgcagtca taaatgacct 3135001 gatcccaaga atacagcgaa gacagcagcg ggaatccggg aaacgtgtac cataaacagc 3135061 agcgttcacc gtttgcagaa gcaggtgtaa gctcatcgag taatggggag agcttatgtc 3135121 tgtaaaagac atctgtatat cgtccgaaac gaaacatttt tttctgcagc aggtctttga 3135181 cagcgaattg cctgatgcca gaatggactt cctgaaactc tttcccttgg gcacgcggag 3135241 ccggacatac ccaaataact tccttcgttt cctcctgagc agctaaaaat tctgccagcc 3135301 ggtgccttct gtatctcaat tggtcttttc cccattcagc agtggcaacg atgacatgaa 3135361 tgattgcttc ttttgtttcc accttcatca ccttttctct ctgtttgcag ctataatctt 3135421 tttttcaccg cgttttttgc atattgaaca aaacaccatg ttgctttcat aaaatgaagc 3135481 cgttcgatct ccctgtagac aaaccacgtt tttttcgcag ccttccattt gttgctggaa 3135541 attgaattat tgacaagccg atattcagcc aggcattcat tcattccata ggcagtaaat 3135601 ccttttttta aaagagacag ccatgtggct aagtcctgtc tcgttctgat attcggcatt 3135661 tggatctgtc ccgtttgctc cctgtcaatc atcaccgtca agcagccgat aattgtattt 3135721 ttcagggcgt catcgtacgt caggctttcc ggcgcatgaa taaatttatc gagcggggtc 3135781 ccgtcctgcg ccattaagct gtagcccgtg aaagagaacg cacaggagcg ctccatcata 3135841 aactcaagct gcttttccag tttgtctttt ttccatttgt catcactgtc caaaaatgct 3135901 acgtagcgcc cttgagcgcg ttccaacgct ttgttgcgag caaccgcagc tccggagttc 3135961 tcttccagat acaccacatg aattctttcg tctatttttt catactgctg taaaatgtcg 3136021 cgggtcccat ccgttgagca atcatccacg ataatcattt cccaatgagg atggctctga 3136081 tctaataccg aatgaaccgt gtcttcaata tagtcacgcg cattatagga aggtgtaatg 3136141 acagatacga gaggtttcca attggtcatg atcacatctc catcgtatga ttttaaaagg 3136201 attctctgaa aaattcagga atgacaacga acataaaggc aatcgtaagg ccaatcataa 3136261 cgccgagaac tgctttcttt ttcggagaca taccgccgcc tgctgtctca cttacggttt 3136321 cggaatcagt aacacttgcc gctttcaggt taagctgtgt gtttttgagt tcatataaaa 3136381 atctctcttt atccactttg gaatcctcgc tcaccgactc gccttcaagc gcgtctatgc 3136441 tgctgcggat gacggcttct ctttctgcat acagcttttg atcgtttttg aggaaggtgg 3136501 aggatatggc gtttaagaca gattccgttc tatccttatc ctcgtcacta tagcttaaag 3136561 tcagtaacga tttggattcc gtattgattg taagcttctc tttgatctct gctacatctt 3136621 catccttttc atcaggaagc gcctccttca aaaaggagtc gctctttaat agaagcggaa 3136681 tctcttctgt gctgttataa accggatgat catagctccc cacagccaaa gtatcttcag 3136741 ctgtatagct cttttgatca gcgatctgtg acggcaggat ataccccgcc gcacctaata 3136801 taattggcac cgctatgatc caaatgatat ttttttttat gcgacgggct attcttatca 3136861 atatatcgtt catataagtc tccctgcttt ttgtagtctg tttatctgta catcggctca 3136921 ggcatttgtc tggatcgcct taacacattc acggcggcga tgacgagcgc cataaacacc 3136981 caatggaaaa ataaatttga aacagagctt gggctgatac ttgataccag gaaactgacc 3137041 atagcggtaa taagtccttc tgtgatcagt tttgactgat tttctaattt tctttcataa 3137101 aacttgtaaa gcacccatat gaggtaggca taaacggaca aatatcccag catgatgaac 3137161 aaaccaaaat tagcaagaat ttcaacaagc cagttatgca cctctgccac attgtcagta 3137221 tcatatacag cataatgctc aagataatag gatacatttc ctgccccgac tccgaatccg 3137281 tatgaatcaa ggaaaaaatg ccaagcgttt ttcagcagat ttgcccgagc cacatttgat 3137341 ggaagcctgt catgaaatga atgcagcgtc tgcggggcca gaaacagctc ccaaaacttt 3137401 gaatagattt tgctggcgaa aagaactgcg aaaagagcaa ttcccgccgc cgacagccat 3137461 atagccattc tctttaaaac aggcggcaat acaatgaaga tgtagacagc aatacctgca 3137521 aaaatgccca gaaggctggc tcttgaacca gtggcaaaaa ttaaatacaa cgcacagagc 3137581 gagagcacaa ggccaattgc cttgatgtat ccattcttaa tgtttttcat catcgtgatg 3137641 taaaaaaaga agctgatgga taaaaaggtc gcaaagtcat tttgattaaa aaagaccgat 3137701 gtcggataat gctgcttgta ctccggtccg ctgtacaatg tggaactcgc aagatgatgg 3137761 tgggtgatat gattgtaaaa accaatgatc atcagaaata ccgtcatcac cagccaaatg 3137821 gcataaacaa tcatcagccg ctccattttt tgcacgtaca tgacaataag ataaatgaag 3137881 aagatcccca ttgccaataa ggctaaatac ttgaggccaa ctgttaccga cttggcccac 3137941 agcagagaaa caaggccata tataaaccaa aaggcgaaaa agagtaaaat cccttttact 3138001 tgcagcccat gccatctttc aatatgggtt cgattccgaa ccatgccgaa aatatgaagg 3138061 caacccgctg caatgagcag aagccggtaa aggaacaaac tgaaaaatcc aagatgaatg 3138121 gcaaaaaatg cattatttaa aaaagtgcag gcgatcaaaa tatagattac agccataaag 3138181 agccgttctt ttgttgtaaa tgcggttgca agcgtcagta aaaacaggcc aattgccaac 3138241 accgcaagca cagcagccat ctgcatgaaa cctatatctt tatggatggc tcccagcaat 3138301 aggacgactc caaatatagc agcggccagt aacgctagcg tatggaccgc tgatcgtttg 3138361 atactcacat gtttaacccc tttcctgatg tttcaggagc cggcggccga gcctagcagc 3138421 cggcagcttc aaccaagtaa cactttttct ttttataaat tgacgcttcc caagtcttta 3138481 gccaattctt caagcggcaa gcccggaaaa tacttgtcag agggttccgt tccccgaaca 3138541 gcgggacggc cgatagagtg ataaatgtat ccggctgcct gcatctcttc aagtgaaaat 3138601 aaatttctgc cgtcaatgat gactggctgt tttaagaggg ttttcacttt tacaagctcc 3138661 atttctttca cttccggcca atccgttaaa atcaggcatg catcagtgtc ttccatcgca 3138721 gcatacacat ctgtgtaata ctcgacctgt tcgccaagga tcgctgaagc ttcaggaata 3138781 gcaatcggat cgtatgcttt tacatgggcg cccagctgct gcagcattgg gataatatca 3138841 agcgctggag cggatctcac atcgttcgta ttcggtttga aggctaatcc caggactgaa 3138901 atggttctcc ctttgacgct tcccataaca gtcaaaagtt tatctacaat atgaacacgc 3138961 tgcttttcgt tcgtttcaat gacagcttcg atgagcttga atggatagcc tgccgatttt 3139021 gcgatttgaa gcagcgcggt tgtatccttt ggaaaacatg aaccgccgaa tccaatacca 3139081 gctttaagga actttctgcc gatacggctg tcaagaccaa caccatcagc aacttttgaa 3139141 acgtctgcgc cgactcgctc acaaatgttt gcgatatcgt tgataaagga aatctttgtc 3139201 gccagaaatg cattcgcggc gtatttaatc atttctgcac tttctaggtt tgttttaatg 3139261 acaggagcat ggaatggctg atgaagttcc tcaatgatgg cagcggcttt atgacttgtt 3139321 gaaccaatca cggcacgctc catattcatc gtgtcatgaa tcgctgaccc ttcccgaagg 3139381 aattcagggt tagatacaac atcaaatgag tatctcccct ttgaggcttt ttgaacgata 3139441 gattgcacca gtttccctgt tccaaccggg actgtgcttt tatttacgat cactttgtag 3139501 ccgttaagat gctcaccgat tgttttcgcc gccgctttga cgtacgttaa atcagcttca 3139561 cctgttttgg acataggcgt tccgactgca atataaataa tatctgaggc ccgaatggca 3139621 gacgggatat cgttcgtaaa ggtcaggcgc tgatccagca catttttttc aactaagtct 3139681 gcaagccctg gttcatagat tgggattacc ccatttttca ggcttctgat ttttgattca 3139741 tcgatatcac agcaaacaac tttattgccg atctccgcaa agcaagtgcc tgatacgagt 3139801 cctacataac ctgttccaat gacagctatt tttttcacag cgctcaaccc tctcctgtaa 3139861 aatgatcttc caatttataa tggtcgcagt gtcttacgat taaacggacg ttttcgtgac 3139921 cgtctgatac tgatgatgca aggccttggc gttttttcct gcgtcaaatt gagcctgcac 3139981 ggtttcatac aagtcatctg ctacttccgg cttccatatt tgctcatgtt cgtaccgagt 3140041 gatcgcttcc gccaaggctt gagcggattt cggtttaatc agcagatgtt ggtgctttcc 3140101 gaataaagac gacactccgc caacatccgt acaaataaca ggaaccctta gcgccagcgc 3140161 ctcaatcaca acagtcggca tcccctcact gtaagaagga agtacgaata gatctgccgc 3140221 aagtaaatag tctcttacct gatgattcgg gacttggcct gtgacgatat gccccttctg 3140281 cgtcagcgtc gattttgcgg gaccatcccc gacaaagact gccttaggag agtcctgcag 3140341 cgattcgatc gcttcagaca gttcaaaaat gcctttctct ctgaccagcc ggccgacata 3140401 gacagccaga cgctgatcga gcgggagtcc gagtcttttt ctgatttcct ctttcgtctc 3140461 ctcattcccc tgaaaacggc tgagctgtat gccgattggc aaaaccgagc tgtcaaagcc 3140521 cgaaagcttt ttggcttctt cctgaagctt gtggctgact gctaaaacaa ctgacgcaga 3140581 acctacggca cgcttgaagg ctttaaacgc acctttgctg taatgcggat agacattcac 3140641 atcactgcca tgcaaggtca ggacataagg aatttgcgct gactctgaca cgactgccgc 3140701 agccccgccc gatggcatgg caaaatgcgc atggatcaga tccggatata ggtcgcgctg 3140761 tttcattgtt tttaaaacgg ctgatgcgat tctccgatga ggctgcgccc acttcagctg 3140821 gccgggaact gcccgataga aaggccggta aaccggtatc ccctttctaa tctcatactc 3140881 cggtctgaca tccttttttc gatatgtctt tttcagcatg cggacaggtg ctgaatgaaa 3140941 aggccgtggg catatcacag tgatatcaag cccgagtttt tgcagctctt gcacctgtgt 3141001 ctcatgaaac acaccctctc cgggtttcat actgctcgga tatacgcttg tgatccacaa 3141061 aatcttcatg acaaacgtcc ttttcttagt agtttgcttt tcgtttgagg gtacgctttt 3141121 accaaaagaa agagatagca cagcgcccca gccgcaactg aaatggccag ccgcatttct 3141181 gcctgcatac tgaagtgttc ggtactgagg cttacaccaa acgcgatgat gcccatcgcc 3141241 gcagtaatca gaaatggctt cataatcgac tggaaataag ctgaaaggtt aagcttgatg 3141301 acatatgcca aaagccagcg cccaatcagg aaattaacaa cgctgataat ggcatacacc 3141361 catgcgactg tcagcaggct tcccgtctgt acagctgcaa acagtgataa tccgtacagc 3141421 agcagcacgc cggaatccca ataaaacgct aagtcagctc ttcctttagc cagcaacaca 3141481 gatccatttg gattcatgag cactcttagt attccgacaa tcgcaagaac atttaggatc 3141541 ggaacagcag caagccattt ttctccgaaa accgctgtga taaaggcgtc tgacacagac 3141601 acgagcccga ttaacagcgg aaacgaaaca agcgccagca tttttgtcat attcagaaag 3141661 ccttctctga tcacgctgtt ttcatatttg ttttttgcga aaatagggaa tgccacccgt 3141721 gtgacaatcg gattgatctt caaaaccgga atggtgacaa tctgataagc gaggttataa 3141781 atccccaatg cttcagcacc aataaaccgg ccgatcaaaa tcatgtcgat atttgctccc 3141841 agcctgttca caagacggga tgaaagctga aaggctccaa aagaaaagaa atccttcatg 3141901 cctctcaaat caaaaacaaa agcaggatgc cacttttttc ggtatacagc ccaatataaa 3141961 atccctttac tggactgcag caggacttga gaaatcacgt acgccaaaat cgcatccatc 3142021 ataaaaaccg ctatcgctaa atatccgaat gacaatacat ttgaaaaaat ctctattttg 3142081 cttaacgtat taaaatgcag ctgcttttgc agcatatact gatattgctg tccaattggc 3142141 gcgatcaaaa acataatcgc cagaatccga accagaaaca ccagctcttc tctttgataa 3142201 aatcccgcaa tgacaggact gctcacatat aaaagaacaa acagcaaaac gcccgtcata 3142261 atgttaagcc aatacaatgt tgacagctgg cgctccgtcg cgtcgtctct ctgaattaat 3142321 gctgcgccaa aacccatatc gagcacaatc tgggcgaaaa ctgtaaccgt tgtgatcatg 3142381 ccgacaagcc caaattctgt taaggtcatc atatttccaa gcagggcaaa ctgaacaatt 3142441 tgtatgattg taatacacat ggttgaaata cttgtccact ttgcaccgct catgatttgt 3142501 tttgtaatac ttggcatcat attccctact tctttttaag ctcagattga tggtgaataa 3142561 tggaatcccg ttttatcttg caccatcacc cgtccaaact actttacaag tttttaacat 3142621 aatttttaat tctaaagtga aagtcagatt gcgaatgtaa tataaatcaa atatcagctt 3142681 ttccttcggc gtcatatcgt aaccgccgtt cacctgagcc cagacgctgt gtaaagcctg 3142741 gaatctcatt ctggaatttt tccgtaaata cgggccgttc cggacgaggg ccaatcatac 3142801 tcatatcgcc tttcagcaca ttaaacagct gaggaagctc gtcaattctc gttcttctga 3142861 taaaagctcc gatccttgtc acccgcggat cttgcttctg tgcccaaacc gccccagact 3142921 tctcggcatc tattttcatg gaacgaagct tataaagctt aaatggcttc ccgcctttcc 3142981 ctacgcgttc ctgcgtataa atggcaggcc ccggcgtctc caaacaaatc aaaattgaaa 3143041 ataccgcaat cattggcagc gcaatcgcca atccaatgag cgcaaaccaa atatccatta 3143101 cgcgctttat tgccaaataa cgagccgtct tttcagataa tgtaaaagaa tgtatttgtt 3143161 gaactgagaa ttcacgactc acattcatgc ttttctctgc actcactgac acacacctca 3143221 cgatttgttt gggatgttat gatgacctat gccagtcagt ttagcagacg gatgttaatt 3143281 ggatgtaaat ggtatgttaa gaagtgtgaa ttacgtgttt tttctgataa atgttgttaa 3143341 tactctttta ctattttata tacaagtcct atttgtttta atcatttcat ataaaaaaga 3143401 gacaaatctg tgattagatt tgtctctttc gattatctgt aataagatac tgtgccgtca 3143461 tgaatagctt gtgcagcttt atctttataa accgcttgct tcaatttact tgcatctgat 3143521 gcattagtga taaaggcagt ttcaactaaa acactcggca ttttagaata tttaataaca 3143581 tagaaagcag ctgtttttac tccccggtct ctcgttccaa gattagccgc taactttggt 3143641 tgaatttgtt cagccagtct cttgctattt gcagcttgat atgttgtatc gtagtacgtc 3143701 tcacttccat ttggtgatga gctatcatta gcatttgcat gtatactgag aaataaatct 3143761 gcttgtgcag aagctgcttt atttactctc tcctgtaaag aataaaaagt atcattagat 3143821 cttgacagta ctggaagagc acctgaagca tttagctttg tattgactct tttcgctata 3143881 tcaaggttga cttctttctc aaggagtcca ttgccgattg ctcctgaatc ttgatcaccg 3143941 tgacccggat caataaagat tgtttcacct acaactggat tctttagctg attagcaacc 3144001 tttgtgctta cggcaggagt gtttccgata atcataaagt ttgacatgtt tttacttcca 3144061 ataattttac gggctcctgt agataaattt tcaccatttg taagaataag agattgcttc 3144121 ttcttagctg ccagtgtagc tcctgcaata gagtcagggt agctgaatcc attgcttaca 3144181 tatacggtgc ttgttgataa attaagtttt tgtacgatat ttgcagcaag ctcatatctg 3144241 tttgaaccgc taattcttgt aggagaaggt aacttgttgt ataccgtatt gctgatactt 3144301 ccagtgcctc ctacaacaac ggtactcgaa attcccttat cttttatcac agacgtagtc 3144361 gcactattta tagatgtttt atttgtaaaa agaattggat acccgttttt cgctgcataa 3144421 gggatgacgg ccggagcgtc tgcatataag aagccgttca aaataacagc ttttgaagtc 3144481 gcacccatcg cttttgccac ccgtgcagcc gtatcataac ggttgcttcc tgcaattcgt 3144541 ttaatactta tccccaagct tttaatctgg ttagcagtgt tagaagaaac agcaggtgtt 3144601 ccgcctacaa taattacatt tttagtctgc atctctttca atcttgtttt cgtttcatat 3144661 gaaagcttat cagaattagt gtaaagcaat ggcgcattct tctggtaagc aagaggtgct 3144721 gctgaaatag catctgcata ggaactccca ccaacaatta cagctgtact tgctgttgaa 3144781 tacatttgct ttgatatttg tacagcagtg ccgtatctat tgcttccccc aactcttttc 3144841 actgagttat cggccaaagc tgttggcaca aaaagtatga gccccagaaa acacattgtt 3144901 aggactttta tataagaacg caattgattt cctccttaaa tggcgttata tcctaaaata 3144961 atcaataact tgtcagagtt gtacctggat agtaaaattt caaaattgaa ctatatgaat 3145021 ctccagcttc tgctcttgct tttgctccat attgactcat tccgatcccg tgaccatatc 3145081 ctttaccgct gattgtgtac tttgaagtat ctttttttac agtcacataa gtacttttaa 3145141 atacagtcgc tccaatcatt gttcttaact cacttgttgg tacactaatg gttgtaattt 3145201 tgctcaagtt ataggagcca gtactgcttt taacaaaata cttcactttc atcgatgctg 3145261 tttttgcacg ctgcccttgt gtcgttccac taaagcttaa atcgtcaata cttgcaattt 3145321 tgacagaatc agcgcttgtt tctttatttt tcaagatcca gttcttaact ccggaaagtc 3145381 ttgcagaatc agtttcagtc gctgaagacc accaagaaga aggcttcgtt aagtccaaag 3145441 atttcgtatc tagctgttgt tttgacaaag taagcgtcca gcctatttga ggatcctttg 3145501 tatctttttt tgcaatcaag taaggtacac ttgacgacca cacttcatta ctagcttctg 3145561 tgtaaccacc attactggaa gaataagctg cagttataag agatccatta tatttcagaa 3145621 ctttcccctt cgtttgctct accgctttat tggtattcga attccaactg tagccaccat 3145681 aaacttgaaa agcggttgta tcaggtacag tagttcctgt ttttgttatt gagtaggttc 3145741 ttgcagcgac agtctgtgct ttaagagcct caagtgacca gctagcaggc atttcattcg 3145801 gaattactcc ttttaagtaa tcctcaaatg gaatattctc atttaccggt cggatatatt 3145861 tagtagactc aatagagaaa ttaaccgtgc caagatactg ctttccatca agactaattc 3145921 tgtttgaagt agaatagttt tctggtttaa ttcttaggga gtttccgtaa gttttgatgt 3145981 tttcaaggtt taattttccg ctgttgattt ttagattata ggtgccaccg tcagctaaat 3146041 aaaattcatc agcaagtgaa ttctcaactt cagcagaaat tgaactggta cttccaataa 3146101 agtcgtatgc atatgtggct ttatctttcg ttatactttt agccgcagcc ggaacgctat 3146161 cttgtttaac aaataaaatt tggctgtttt tcttcgaggc aagcgaagcg cctatcaata 3146221 cgtctgcata ttttgtcccg ttcgtcatta cgactttatc agccttcaac tttagttgct 3146281 taattatatt tgccgtaagt tcatatctgg ttgatccagg aatcctttgc acagttgaag 3146341 tttttttaat ttggttttct acactatcac tgacgctaaa tgaactgcct ataatgatga 3146401 cttgttttgg caaatcataa tccggaagct tgtctttctc tgtaagcaaa atagggtatc 3146461 cgtgtgctgc tgcatatgga gcaatggcta aagcgtcttg aaatactctt ccggttacaa 3146521 cgatcgcttt atcatagctg cccatttgct ttgcaatatt ttctgataag acatatctat 3146581 tttttccgct tatccttttc acagcgccat atgatttcag cttgttttct acgtcttttg 3146641 aaatgcttcg cgctccccca atgattaaaa tattatcagg gttaaactta gcaatttgtc 3146701 tttcagtagt ttttgttaac gtgtcaggct gagtaaataa aactggtgcg ttcagttttt 3146761 tcgccaatgg aataacaggc aatgcatcaa taaaaatatc tcggttcacc aatatcactg 3146821 tattaggatt tttccactgg ctgttggatg caagagtcgc agtttcgtat cgtgaagcgc 3146881 ctgcaaaacg atccgtaaca gcaacattat ctccagttac tttataaaat cctgttggcg 3146941 atagactgat gctagattta tttccaatat aatttaacaa tttaactgag atgtttgagt 3147001 ctgctgcaaa agaaactgat ggaatcaata ataagattgc agcaagtgaa cacactatca 3147061 attgtttgca agatttcaaa atttcaggtt cctccctata tcttagttgg cacgttcaat 3147121 atcttttaac agaagctgac cctcatcatt tttttcatat gtaatcgtga ccttatctcc 3147181 actgttaaac ttatcaagat cacttgtcga ttcttcagtg atatcaagac taaccggctc 3147241 attatctact gttacttcta ttgtatgagt atcagctaac cctacataag taccttcttt 3147301 tgtttcaatg ttactgtctg gcgatacatc ttcaccttga ctcttttgac tattaacccc 3147361 gcaacccgaa agaagcaata taaagaacag taaagcaata aattttttca tttttttcac 3147421 ctcattatat tttatcgtca acctatttta tattttaaag aaaaattaag aaacaatgaa 3147481 actttttttt ataaaaaacg actattttag gatttcattc ttgtattaaa tagagttgta 3147541 tttattggaa atttaactca taatgaaagt aatttaacag acgaggtgca aaggatgaga 3147601 aacgaacgca gaaaaaagaa aaaaacttta ttactgacaa ttttaacgat aatcggactt 3147661 cttgtactcg gaactggcgg ctatgcatac tacttatggc ataaagcagc ttcaaccgtg 3147721 gcaagtattc atgaaagcat tgataaatct aaaaagaggg ataaagaggt cagtatcaat 3147781 aaaaaagatc ctttttccgt cttaatcatg ggtgtggatg aacgcgacgg cgataagggc 3147841 cgtgccgata cgctcattta tatgaccgtt aacccaaaaa cgaatacaac cgacatggtc 3147901 agcattccgc gtgacacgta tacaaaaatt atcggaaaag gcacaatgga taaaatcaac 3147961 cattcatacg ctttcggcgg cacacagatg acggtagaca ctgttgagaa cttcctcgat 3148021 gttccggttg attattttgt gaaagtgaac atggaaagct ttagagacgt tgttgataca 3148081 cttggcggca ttacagttaa cagcacattc gcgttcagtt atgacggtta ttcgttcggc 3148141 aaaggagaaa tcacgctgaa cggaaaagaa gcgctcgctt atacccggat gagaaaagaa 3148201 gatccgagag gcgacttcgg acgccaggac cgccagcgcc aagtcatcca aggtattatt 3148261 aataaaggcg ctaatatttc ttccatcacg aaattcggag atatgtttaa agttgttgaa 3148321 aataatgtga aaacgaactt gaccttcgat aacatgtggg atatccagtc cgattacaaa 3148381 ggtgcgcgga aacatattaa acagcacgaa ctaaaaggta caggcacgaa aatcaatgga 3148441 atttactact accaagctga tgaaagcgcc ctttccgata ttacaaaaga gctgaaggaa 3148501 agcctcgaaa agtaaaacaa aaagaagctt cgcacaatgt gcaaagcttc ttttttattt 3148561 gcctgtaaat gaatccggtt gttcttttcg atacccgtaa tgaaacagca attcttccac 3148621 aatccggcgg gaagcctctc catctccata cggattagaa gcctgggaca ttttcttgta 3148681 ctcatcagga tcagttaaca gctgttttgc aagctgataa atgttttcct catccgtacc 3148741 tgcaagtttc agcgttcccg cttccactcc ttcaggccgt tccgtcgtat cacgcagaac 3148801 aagaaccggt ttcccgagag atggggcttc ctcctgcacg ccgcccgaat cggtcaatat 3148861 aaaatgcgat ttcgctgcaa agttatggaa atcgatcacc tctaaaggtt caatcagatg 3148921 cactctgtca gaatcaccaa aatgcttatg agccgcttcc cggacaacag gattcaggtg 3148981 cacagggtaa acgacttgta catcttcaaa ttcccctaca attctgcgga tggccttaaa 3149041 catgttttcc attggctcac ccaaattttc ccggcggtga gcggtcaaga gaatcatttt 3149101 atcctcaccc acctgatcga gaacaggatg tgagtaacca tccctaaccg ttgtgttgag 3149161 tgcgtcaatc gctgtattgc ccgttacaaa aatagagtcg gcctttttgt tttcttttaa 3149221 taaattgtct ttcgcctggc ctgtcggagc aaaatgcaaa tcagcaatcg cccctgtcat 3149281 ctgtcgattg agctcttccg gaaacgggga atacttattc cctgtacgga gccccgcctc 3149341 cacatgaccg acagcaattt gatggtaaaa agcggctagg cttccggcaa acgtcgtcgt 3149401 cgtatcacca tggacaagca caatatcggg tttgatatct ttaaacaact catccaatct 3149461 tacaagtgcg ttagacgtaa tctctgccag tgtctgccgc tccttcataa tgttcaaatc 3149521 gaagtcaggc ttgatgtgaa acgcatctaa cacctgatcg agcatctgtc tgtgctgtgc 3149581 agttaccgtt acataggaat ctatttcagg atattttttc aattcaagca caagcggtgc 3149641 catcttgatc gcttcaggcc tggtcccgaa aacggtcatc acttttagtt ttttcatatt 3149701 tgtcacctgg ttttctgcta tagtaaataa attcatacta catattctac atgaaaatgc 3149761 atcattttaa atcatttcat tcttgattca aataaaatga tataagtttt aatattaagg 3149821 ataaagcttg tttaaaaatg gtttatccga tatcataaaa atgtgtaaaa acatattgaa 3149881 aagggtaaat agagaatagt ttaaccataa attttttcga tcataaggaa ggtgcctttt 3149941 aaatgaaaaa agtacgtaaa gccataattc cagcagcagg cttaggaaca cgttttcttc 3150001 cggctacgaa agcaatgccg aaagaaatgc ttcctatcgt tgataaacct accattcaat 3150061 acataattga agaagctgtt gaagccggta ttgaagatat tattatcgta acaggaaaaa 3150121 gcaagcgtgc gattgaggat cattttgatt actctcctga gcttgaaaga aacctagaag 3150181 aaaaaggaaa aactgagctg cttgaaaaag tgaaaaaggc ttctaacctg gctgacattc 3150241 actatatccg ccaaaaagaa cctaaaggtc tcggacatgc tgtctggtgc gcacgcaact 3150301 ttatcggcga tgagccgttt gcggtactgc ttggtgacga tattgttcag gctgaaactc 3150361 cagggttgcg ccaattaatg gatgaatatg aaaaaacact ttcttctatt atcggtgttc 3150421 agcaggtgcc cgaagaagaa acacaccgct acggcattat tgacccgctg acaagtgaag 3150481 gccgccgtta tcaggtgaaa aacttcgttg aaaaaccgcc taaaggcaca gcaccttcta 3150541 atcttgccat cttaggccgt tacgtattca cgcctgagat cttcatgtat ttagaagagc 3150601 agcaggttgg cgccggcgga gaaattcagc tcacagacgc cattcaaaag ctgaatgaaa 3150661 ttcaaagagt gtttgcttac gattttgaag gcaagcgtta tgatgttggt gaaaagctcg 3150721 gctttatcac aacaactctt gaatttgcga tgcaggataa agagcttcgc gatcagctcg 3150781 ttccatttat ggaaggttta ctaaacaaag aagaaatcta aacaaaaagg ctattggaca 3150841 ttcatccaat agcctttttt tatttcaaca tcaaagtcaa tgtatgctct tcattatcaa 3150901 ctgcgaagac ctgatcaacg gcctgccgca aaaattaata atcccagaca aacacactga 3150961 ttgtagagtt aaacaaacta aatgaaaaca taaatacaaa catgcagatt aaatagtaaa 3151021 tatcttgtat tcaatgcaag ctaagtaaac accacttgct aaaagaacaa tgactaaaca 3151081 accagcatta caaaataatt aaataaattt gaagcaatta caacagaagg cagtgaactg 3151141 tcggaaagtt cattttggct accatattaa tccctttaac tacgctgttg gatttatcaa 3151201 gaattgtcgg gctaatagaa aaccacggaa tcaaaccagc cagcattcaa acgataaaag 3151261 gcacttctcc gatacctgtt atgaccagct tactgttgcg catcccaaat acaaaccagt 3151321 acgccatcat tagaataagg ggatttaaaa cctgccataa tacaccaaaa taattgattt 3151381 tttggatctt tcggttaaag aaatttaaaa gtaccagtga atattgtaac aaatgttgag 3151441 tttttttcac ttttaaaaag taaagagaag tctcgcagaa cttctcccaa catttgaagt 3151501 gtcaatataa aacaaaccaa cctcatttag caactttatt attatctaat tccaaaatag 3151561 cattataaat acgattccta ttatttttat cagtatatgc aaaaaagtta tctactcttt 3151621 ttctatactt atcttccata cgactattgt ttttcatata atagataact ttatccacta 3151681 agctattatg attttctaat acatcaccaa accccatttt tttataatca taataatcaa 3151741 gtttaaaatg gtatgacttt tcgtattgat aataaataac aggttttttc tcatatgcaa 3151801 aatcaaacgc aacagatgaa aaatcagtaa tcattatatt agaagaatta aatagcattt 3151861 gatagctgct gttatagtcg gcaaactcca cataatcatg cttttcaaag tctacaatct 3151921 gttgctgaat atctgggtga ggaaaaaaag ttattttata attatttttc ttagcaaatt 3151981 cgattagccg ttcatcatta atcaaagcat tatacctaga aaaatattca ctatctttaa 3152041 atttcgggtt gtacggtctt actccttttg cctgatcttt cggtaataca atatcttttc 3152101 tccaagtcgg cattattaga agttgctttt ctccctcact cttcttaaga ttatcgtatc 3152161 tcggaaatcc acccaacaaa atattctctt ttttatagtt gtaattccct ttcacaatag 3152221 accgatattc aggtttggca gaagtgacta ataatttgat attcttgttg tatttgttta 3152281 accattcaga atgatctgcc attgttattc cgtgctgtaa aaagataaac tcaaagttaa 3152341 ataaatctct aaaataaatc tccatattaa aaaatggatt tacaacccat atatctgcat 3152401 gtgtcgatat tactttggaa gaggataagg ttaaaatttt atgtctaaaa gatctgtatg 3152461 gtatgacctt tccatatttt ttgattctgt cgtaatcctt gctatctttt tttattataa 3152521 agtatttttt taccccatca ttcttgttga ttgcatattt aaagaggtgc tcggcattat 3152581 catcagcttt gtcttgtctg tctatgaata accatactgg ttttctatta aaaatagtga 3152641 aaacatggtg taccattctt gccatcagtg ccttcttaat cgctgatttt cgtttttttg 3152701 atttttcccc tgatttatgt agggatttta agaaacgaaa ctcttttata aatctatttt 3152761 taaaattgtt ttttttgaac attaattttt tataattata ataaaaaata taatcttttt 3152821 tagccacata agtattatat aaatcgtttg acaaacctga atacttgaaa aaacgaagtt 3152881 ttgtcaactt ccttttttta cccttagtta taaaaaactc aatatgatga ttatctgcta 3152941 gatgaccttt gggaatatct attgaaaaac cgggatattt ttttattact tctcctaaac 3153001 ttatataatc attatgctgt ctttttatat tctttgcttt tatttttgtt tcgccaattt 3153061 tagcataaaa cttaaaacct ttagaattaa acagcgagct ccaaaagcct tctatgtgaa 3153121 tggaatcctc attttcttct aaaatttcaa tagttaaagt ttgatccgat aatttcgaaa 3153181 caattttacc ttctctgtat aaataataat cctgttcagt ttctctttca tatacatacc 3153241 tactataatt ttcaccgtgc tttattttta aagcatgata taaatagaaa tggctgacac 3153301 tttttgtttc aatgatgaca tcgtcgtcaa tatacgacaa tacttctcga atcaatgtta 3153361 aaaattcact gtattcattt tcgtctaaag gtgtttcact gatatcctta atcaataatt 3153421 tccacttcaa atcatgcata accatatatt gaagaaataa aggtattttc tgttcatgat 3153481 tttttataat atcgattaaa ttctttgaga aagtgataag tgaatggtta aaccaattct 3153541 tatttgcttt agcagtctgc atggcagatg atccatcttc tctaactcta taatggtatt 3153601 ttgcctcttt aaccagacca tactttttct tttgcgatat gattaaatta actagtttgg 3153661 catcttcacc tattttacaa ttttcatcaa acctgatatt tttcaaggca tcttttttta 3153721 taaatgtaga acaacaatga gttaatatat gatgcggttc tttttctaca tccaaaattc 3153781 ttgtagaaga aaacttatta tttagattat gttctccagt tcttccttct gcaaaaaaaa 3153841 tagggattgc tacaatatca atttcattct tatgttcgtc aaagaagttt aaaacatttt 3153901 cgaatgttcc ttctgaaact aaatcatccg gatccaaaaa ttgaatatat ctaccttcag 3153961 catactttaa accataattt cgagcactgc tcactccgcc attctgtttc tttgcataga 3154021 caatgttatt gggatatttc tgagcatatt ctttacaaat gatttcactt ttatcggggc 3154081 tatcatcatt caccagtatt aactgaatat tctcaaaacc aatagtttgg ttaatgatac 3154141 tttctatagc ttcagtgaga tacaactcaa cattataaat cggcattata acactgaaat 3154201 catagttaaa acttttttcg ttcataaaag attactccta acataatgtt tatatgaata 3154261 agaattcggg taaataaaat taagaaacaa gagagtacta atttttgcaa aacaatttta 3154321 atttagtaaa atgtatgaaa agcattcctt accttttttt aaaaaccctt gtaagcaaac 3154381 ttttaaaaat gttcacatgg ttaagttcta aagaatcatt tggtgttttt agtacaaagt 3154441 caaatgcaaa ggcccaaatc ggtatttcga caacaaaacc agcatatcta aaatctctta 3154501 atttatatcc ccatacttca attgtttttt tcagttcttt tcgtttgcat ttttttaatc 3154561 ttttaaaata ttttatatat attctgtcat tttctttcat ctcataatac tggttaataa 3154621 agtgccctgt taattcaagt ctaagccctt ttatttttgc cgaagtaaca gtacatgaac 3154681 tatgcagtac tctttctttt tttatatttt caagagcttc tgtattttct tttaataagt 3154741 gaaacataaa ttctttatag tacatcggca tatcttgttc ttttataaat tgcgggtcaa 3154801 taaattttaa aactttaata aaatcatcaa caaaaactct ttgttcttgt tgatctaaaa 3154861 cagacttata aacatctcta tagttcggat ataaaaacag ttttatatga tatacaatta 3154921 aaaattgcaa ataaggcaaa actatatcat atttgttgaa tgaatccatc aacaaagtca 3154981 tgtaacattc attcaacaaa tatgtgtacc tttttttgtt aaaccatgaa cgatcaacta 3155041 aagaatcctg ttctttccgt tttctataaa aatactttcc ttctgcaact gctccgtatc 3155101 ttttttcttt cagtaataac tggttaaaaa agatagcgtc ttcccaaaac tttatagatt 3155161 catcaaaaag gacggtacta gttagtgtat gtcttctgta aaaagtgccg ccaatataaa 3155221 aatgaatagc tttataatcg ttgagaatat ttataactct tgttcctttt tcaaatctat 3155281 tatttaattt atgtccccct tctttttcac ctgtgtaata aacaggtaat accgcaatat 3155341 ttacatgttc ggaatcacaa aaaaaatcat aaacactttg cagcgcattt tgagagaatg 3155401 catcgtcaga atcaagaaaa ccaataaatt tagatctttc gcttacattt gataatccac 3155461 aatttcttgc agcagaaggt ccagagtttt caattttcat gattttaata ttattaggat 3155521 atagattttt aaaggattca caaatttgag gactgctgtc aacactacca tcatctatta 3155581 atatcagttc tatattttcc ttaaatccaa ttgactggtt aaggacactc tctattgaat 3155641 atcttaaata attttcagaa ttatatattg gtataattat agaaaacatg tttgtacctc 3155701 tttatttaga agttaaagga tcgtttcaat tactctttta gaagccttgc ctcttctaaa 3155761 ttacaaaatt tattataaaa atcctcatag ttatgatcta tataaggatt atgtaacaac 3155821 tcttttaccg tatctataag ttcttcactt gtttgaagca agtttcctgg cgttttttgc 3155881 tgaaaattaa agtaaaaacc tctgatacag tctctataag ccgggagatc atacacaaaa 3155941 aatacaaggt ttttttaaaa attcatatta tcaaaaaaga cagaagaata atccataatc 3156001 aataaatcac taattaaata taaatctcga atatctttat ttaaagaaac atcgttcaca 3156061 aaatatttat atttccctaa ttaaattgtt ctgaaactgg ataataccat tcttacaaga 3156121 ataaccatag agtctccaag gttccctctt catttcctct aatcaaatta aagttaaatt 3156181 tatactggcc agctttctta aaattcatta tcccgcaaag ttggtgcata taaaattatt 3156241 tttctttaat tccttatttg ataatgtaga attggtaggg gattgtagct aaactgtttc 3156301 cagaatagct ttcaaataaa attaatttat tgtttcttgg cagaaggaca aaaattttaa 3156361 acaaaactga ataaactcta actagtaaac ttctgcaatt ggttataata aaaatttcat 3156421 cagtgaactc cttaaagagt gaagattaat atttacgcaa acaagaaaaa aagaagcaac 3156481 tgaatttact tcaagcctct tttagttagt gcttctataa actagccata tcttttctga 3156541 tttgggtagt tgaaatgcct gctattcttg taaggtaaat ggcctcatag tattcctttg 3156601 tagacaatcg tacgattaag taatcccagg ttcttttgct ctttccagta gcttcatatg 3156661 tccatagtga aataaatcaa acattccgta cgtatcactt tcttcattag ataacatcac 3156721 cttccaacct tttccaactt agaaaaaaca aaaatcctta actgattgtt tatcatttcg 3156781 acatattttt tacgttccat taataataaa caataatagc atatgttcct ataaaagtta 3156841 aggctcttta aaaatgtaaa tcatcagcac tttttgacaa tatcgttgca ttgatgtgta 3156901 ttttttacag atctgatatc ttatctatac tcattacaac aagttttcta ttccggaaga 3156961 gtcaattctt tttgtcgcgt tttcaagtgt aatgattttc tttctgctgc gtcatttatt 3157021 ttgtacgccc tcctcatatt acttcatcgt caaaacgtga aggaattgta atacgtagtt 3157081 cctaaaaatt ttcgtggtaa aatttagtga agtctttatc aggctaaggg actttatcta 3157141 aactacgaat tacatatgga gatatataga tgaaaaggag ggttgatatg atataaacga 3157201 aaatcaatta gataaaggaa aaactgaaca cttctgaaaa aagtgataag tttctttcac 3157261 tatatcctcc aaaaagaacc taaaggtctt ggacatgctg tctggttcgc gcctaacttt 3157321 atcggcgatg agccgtttgc gtttctgctt ggagacgata ttgttcaggc tgacacacca 3157381 gggttgcgcc aattaacgga tgaatatgaa agaacacttt cttctattat cggtgttcag 3157441 caagtgcctg aagatgaaac acactgttat ggcatcatcg ccccgctgac aagtgaaggc 3157501 cgccgttatc aggtgaaaaa cttcattgaa aaaccgccta aagacacagc accttctaat 3157561 cttgccatct taggccgtta cgtattcacg cctgagattt tcatgtattt agaggagcag 3157621 caggttggcg ccggcggaga aattcagctt acagacgcca ttcaaaaact gaatgaaatt 3157681 caaagagtgt ttgcttacga ttttgaaggc aagcgttatg atgttggtga aaagctcggc 3157741 ttcatcacaa caactcttga atttgcgatg caggataaag agcttcgcga tcagctcgtt 3157801 ccatttatgg aaggtttact aaacaaagaa gaaatctaaa caaaaaggct attggacatt 3157861 catccaatag ccttttttta tttcaacatc aaagtcagtg tatgctcttc attatcaact 3157921 gcaaaaacct gatcatctgt attcacaaga aaacgcttct tgctgctgtc atacaataca 3157981 tcgctatcac ttaaggatag tgacgccggg ttgataggag aaatgttatg aaaaataagc 3158041 tctgttgctt tatcattctc cagtacataa ctgatttttt cataatcaaa attcagcgtt 3158101 tttctgccgt cagccttatt tccttcagta taaccattca atttcgattg aatgctggtg 3158161 ctgctgtctc ctaggaattt cagaaagtat tcataggaag atgctgcgtt ttgcgagaca 3158221 taagacgtaa atgcagtggc atgcaattca gcgtgtttca tgttagttgc aacagcgctc 3158281 tgtttcacat aataagagtg cccgtcaaac tttattttcg ctgcttgttt gccttttgca 3158341 gctaccgtta cttttgtacc gaatggcagt gtaacgtcag ccttctgttt caaaccctga 3158401 tccttataag cagccgcttt ttcatttgct ataaaccctt gcttattgat tgcagttaag 3158461 cgttcctctg acttgccctt tgcatcgcca tgatggttct tcacttcatt ttgcggaata 3158521 gcgccaaacg aagcaattgt acgaagcggg gcattaaaga acatcgttcc cgccatgaag 3158581 acagtcagaa tagacaaaat agcaatttga atggcattgg ccagtgattt cggctttttc 3158641 ttctttttgc ggaaacgggc aaacgcttca ggatcttctt tcttcctctc ttctgtctgc 3158701 tcttttttat atgtctcttt ttcttttttc gatagcttat taaaccagtc aataaacgct 3158761 ttgtactctt tcacaaccgt ttttgtttca tcaaacatac gaagctcgcc atagtgcatc 3158821 caagcaacac ggtcacacat cttttcaatc tgaccgattg agtggctgac aaagaaaatc 3158881 gtttttcctt gctttttaaa ctcatttatt ctgtctacac acttctgata aaacgtttgg 3158941 tcccccacag aaagagcttc gtcaataatt aaaatgtcag gatcaatatg cacggagatc 3159001 gcgaaaccga gacgcgactt catcccgctg gaatagtttt taaccggctg attaataaaa 3159061 tcgccaatct cggcaaattc aacgatgctg tcatacatat catcaatttc tttattggtt 3159121 aaccccatca tcaaacactt gagccggaca ttgtcccggc ccgttaattg gttattcaaa 3159181 ccggcagcaa tcgcaatcag cgacggctgg ccgttcattt caatttcacc gctggtcggc 3159241 ggaataattt tagccagcag gttagacatg gtcgattttc ctgacccgtt tattcctaca 3159301 aagccgattg tctccccttc atacacgtca aaggagacat tccgcacagc aaaaaaacca 3159361 ttatccttag ccggaaaaaa caatccttta atcttgtccg attgtttttt atacaaatga 3159421 tactgctttg aaacatttcg aaacgaaact tttagtttca tcgtaaaatc tccttacgta 3159481 ttaaagaaag tcaacaaact tgtctctgaa tttcatatgc aggatagaac ctactaacaa 3159541 taaaaggaat gtgaacaacc aaaagtacag cgtgtacttc atgtcatgga aaaaccatgc 3159601 tccatctaag aagctgttcc ggaatccttc aataatatag aatagtggat tcaacttcag 3159661 aacaggcact aattcggggt ggctttgacc gagtttcgca ttaacatccc aaaaaattgg 3159721 caacaagaaa aacaaaagtc ttgttacggc ctgcagcaaa aattgataat ctctaatcag 3159781 cacactgatc gttgagttaa acaaactaaa cgaaaacata aaagcaatca tacagatgaa 3159841 gtaataaata tattgtaacc aatgcacact cgggaacaca ccattaacta ggagtacaat 3159901 gatataaatc accatcatga tcatataact aaataagtta gatgcaattg ccacggacgg 3159961 tagagaacta atcgggaagt tcattttagc caccatatta atgcgcttaa atacactatt 3160021 tgatccatca agtatagttg gactgatgaa aaaccatggg attaatcctg ccagcatcca 3160081 aataataaaa ggcacttcgc ccgctccggt tgtcacagga ccgccctttc taatccccat 3160141 accaaatacg aaccagtagg ccagcatttg gataagcgga tttaagaact gccataagac 3160201 acctaaataa ttcatttgat atttagactt ggtttcataa gccgccaatc ttaaaattaa 3160261 aggaaatgac gttatttgct ctctgagtat acgcaacaaa tcattcattt tttatcttcc 3160321 ttagacttaa ttgtttttgg gaatctttct gtttaaaatt tgaaagcacc gctgattatt 3160381 gtaacagatc ctgcattttt tttcacttct caacaagtat ctaaaaagct gccgaaaaat 3160441 cgacagctat acattttata aaataaccta aattattcag ctttaaatac agtattaaca 3160501 accttttcag atgaacgtcc tgactctaaa tagcaaaact tatcatagaa aggaccaaaa 3160561 gaaaccggaa gcttataatc aggcgatgag atctgcttga tagcctcaat cgtttcttca 3160621 gtagttttta ccaaaggacc aggagcttct ttttcaaaat caaagtagaa accacgcaac 3160681 ttgtcccggt aggtttcgat gtcagggaca aagaatagca ttggccgttt taaatttgca 3160741 aaatcaaaga atactgaaga ataatcagta atcagcaaat cagaaaccat atacaattct 3160801 cgaatatcct cataagcaga aaaatcatat gcaaatcctt caaaaggacc taaatcaaaa 3160861 ttctcagcta ccagataatg cattcttaag attacaatat attcatttcc aagttcttgt 3160921 ctaagttgat gcaaatctaa atcgagatcg aacttataac gcccttttgc atagaactga 3160981 tcatctctcc atgtaggggc atataaaata acctttttat cacgaggaat atttaaccta 3161041 ctctttatca atgatattgt ttcctcatta ttatcattat gaagaaaatc atttctagga 3161101 tatccagatt caatcattgt cttgttaaac tgaaacgccc gtgtaaagat ctcagttgaa 3161161 taaccatttg gggaaatcaa gtaatcccaa ttagaagctt ccttgataaa attcctttta 3161221 tattttttgg tgtttgtacc aggcatatgg acttcttcca tatccattgc aagtcttttt 3161281 aaaggtgtgc catgccatgt ttgtaaatat gttgtatgac taggtttcgg aatccataat 3161341 ggaagccggc tgttaacaac ccaatactca gctcttgcca tagcgaagag ccattttaat 3161401 gagaggcgat taatgtaagg aattcccttt tcatcaaaag gcgctgaata ttgtttattt 3161461 acactccaat acattttata ctcagggtgg ttttcccgca tatattcgta aatcgctctc 3161521 ggattacaac tgtattgttt cccattaaaa ctttcaaaaa tgactgtttt ccttttaact 3161581 ggcattctgc tagccatcat gaatagagat ttgtatgttt tagtgattaa cttgtttctc 3161641 atttttgtga tcttttttat ttttgatact aatctcttct tctttccttt aataaagtat 3161701 ttcatccttg ttttcaggct atagtcgttt actctgatac ctagagtctg ctttttcttt 3161761 ttcttaaaga cttcataacg aactggtgcg ttgtttgttt taataatact tactaatcct 3161821 tttaatttgt tttttcgatc tcctaaaaca agagcagtgc tgttgaactg aatatccgtt 3161881 ccttcatcgt cattgcatat atactccata aaaagacgat aaacataacg tttttcattt 3161941 gagaaaggaa tttctttcaa aggcactttc acttcaaaat catacagttc cggaacaaaa 3162001 ccatctgctc tcatgttttc caggccatgt gtttttcttt ctagcttgat tggaaatttt 3162061 tcctcaatag gtgtttctcc accctttttt aaaataaggt tcaagttttt tatccgatat 3162121 tgattttcgg aactcaggta ccccgcataa cctgttatgc ttatttcttc agagctaatc 3162181 tcgatttgat caaatctgat gattttggcc tctcttttca ccttaataga aaagttgcct 3162241 ttatcagttg tataaggtaa aatcaaaagt tctgtggttt gatcgacatg aaaggcgcgc 3162301 tcaattgaat ttacttcagc agaaagacgc ttcaagagtg gttcctgctc cgcatcttca 3162361 tatttttttc gaaattcgac ataaaaatca tatgtttgtc ccatttcaac aggcataggc 3162421 aaaacatgag catttatctc agttttatac tctaatgagc cagtgttttg aagcggaaat 3162481 tcagattccg ttcctgaacg tctctctttc agctttaaaa ataactggta atcctctaaa 3162541 aattggtgtt ctgaatcaat tgagattaac aattcaagac ttcctaaatt gtttttcaag 3162601 cttttcaaaa tacatttaat cacagtgttt tcaatcatta cttttttctg ctcctctgta 3162661 taaaagctct ttcctttttg cttcctttta ttagtgtcaa ctactaagga cattaactct 3162721 cttttatttc cgtgaccctc caagagaaat tgcctttaac tgttgtatag ggctctactc 3162781 tatagccatt attagtatct atactgtttc ctgacaattt tgtttcttca ctcgaaagtc 3162841 ttcgcattgt tttaatatgg ccatttgcat tgaaaacaat ataaaaatca ataacttggg 3162901 ttttattagc agctatcttt tcaatattta catctttttc gagatcaatt acaaacagtt 3162961 gatcattttg taagtttgtt gaaataattt cagccttatt ctttctgtcc aagcccacta 3163021 aacgtatttt tttaatatca ttatgatcaa aattctcaat gtcaatttct attttagttt 3163081 tatcaaaatc ctcagtatag gaactaatag aaggatcttt ttttccaacc tttttagaga 3163141 acttctctct ttctattcgc acctcaatca tctgattaag agcaaaagcc caattttcaa 3163201 tatagttggg tcttgaatat ttttcagcca ttttaaaagc ttgttctgaa aatttttgat 3163261 gagtactttc atctttcatc aaagagataa tagcttgacc caatttctct atattatact 3163321 gttcaatgac atatccattt gctccgtcag taactaagct ccttgctccg taatcataat 3163381 cgtatgttac aactggacat ccattgctca gtgcctccat atttgataga ccgaaccctt 3163441 caaaatgaga ggttgaaatg gttagccaag ctttttgaaa ctctgagtca gggttatccg 3163501 tatagccttt caaaaagaca ttgttctgca gtttggtatc ttcaatttct ttttttattt 3163561 tttcgaaatc ttcacccgat ccgaatatat caagttttgc ttcaggaatt tctttcacga 3163621 ctaaactaaa tgcttttact gcatgtatca gatttttcat agatgcaagt cttgaaataa 3163681 tgacagcttt gtatttttca ctcggcacat tcaatacagc gggatcaaga ggcttatcaa 3163741 ttgtatgcgg agtaaagaaa aacgtctctt gttcccctga aatcaattta aaatcttcta 3163801 gctgctcctc agttataaaa aagacagcat ccaaattata catctgacta aatacttctt 3163861 tatagcgacc cttaatttga tatttattgc tgccgtaatg cttgttatga ataattgctc 3163921 cataatagga agaaggtgat tttttcactt taaagacatg tttgtcttgc ggtctgctgt 3163981 ccactaaaaa caacttaggt ttatcatttt gtttttgcag atattctatc caatattgac 3164041 gcagttccga ttcatctttt acttttatct caccctcaag ggagtaccaa ataatatgag 3164101 ataattgaac atctttttct tcattgttcc atacatagag tttgtctaaa tatacttgat 3164161 tttggtcatt aatatattcc tgcagataca tcttgtttag ctgcacatca taatgagtaa 3164221 cgagaactaa gtttccgttc ttcgtatatt cctctctctt tatgagctgg tttttatcat 3164281 tccaatagtc gacgtaccgg atagtttctc catctccgta gtaaactaca gacatttcat 3164341 tgttcttctt accaaacaat ctcaacagag tttttgcaaa tttccccatt ccaacttgct 3164401 tttttatctg gtcaaggcct atcctttctt cgtatgatct tttcccattt gttctaacac 3164461 ttaaaaaatc atcgaataga ttaataacac ttgtgaattt tttatcaatc ttaccgttgc 3164521 tgtacaattc atcaattttt gaagacaact ctaaatcaaa acgaaacgtt aagaaaaagg 3164581 tgttttggtt acactcttct ccaaataatt ttgaacgcaa taataatgat ttcgtcagac 3164641 cgccataatt acttggcagt ccaccagaga taaaataata atccatgtca ggaatttgtt 3164701 ttatattaga ttcactcacc gcatgtaaag acaatttttt actccctttc ggcatctaga 3164761 atatatgatc attgaaattt atatctaccc ggatacttta gtcacaaaaa tcaatgtaag 3164821 catcaaaaag tacttcttat ttcaataaga agtactttaa ttagatattg aaccaatgat 3164881 atcaggatcc taaattataa accagcaatt tcctctttga tctttgttgt agagatgcct 3164941 tctgttcttg ggaggtaaac aacctcacac tgatctttga gaaagtcaaa tttaccttcc 3165001 cagtcatccc ccataacaaa aacatcaata ttatgatcaa taatatcttg ctttttttgc 3165061 tcccaattct tttcaggaat tacttcgtcc acatatcgaa tggtttctaa aattaattta 3165121 cggtgctcat agctgtgata agcttttttt tgcttttgta aattgaattc atccgttgaa 3165181 atagcaacaa ctaaataatc accaagctgc tttgcacgct caagcaattt aatgtgaccc 3165241 caatgcagta aatcaaaagt tccatatgtg ataacttttt tcatttaaag aaacgctcct 3165301 tcctaatgtt aaacactatt aaaaacacta ctgacgttag cgattaaatt ctaaaaacct 3165361 gtttgtattc cttatatcga catatttctc gtatgtcttc actgatcatt aattatagca 3165421 taccgcctaa aaaaggttaa gtactcatga ggagaaaaac attccaaaat atgtaattac 3165481 actcagactc cattggcacc aaggtctgtt gttcattcgt tcattcaatt gtaaaattgg 3165541 aaacatattt aaatttaatg taaagataat gttaatcctt tgttgaagat ttatgttaaa 3165601 atataaggta gcttgatttt gcttttagaa actctcggtt tttaactata taaatagaat 3165661 cttaaaggaa ggaggagcca gacatgcaaa cagagactat tcacaatatt ccttatgtta 3165721 acagtaactt aacatcattt atcgattacc tagagaaaca ttatattgat caaaagattg 3165781 gtgctgtcat ttccacagtc aaccctgaaa ttgcatttgc agctattaaa gatcgggact 3165841 actttgatgt actatcttct tcaaacttca ttttgcctga tgggatcggt gtagtcatga 3165901 tgtcacgttt gactaacaac aggcttcagt cccgaatcgc aggttacgat gtttttaaag 3165961 aacttctggg cgttgctaac aaaaagaaaa aacgcatatt tctgtacggt gcgaagaaag 3166021 atgttataaa aggtgttgta tccaaaattt cttctgaata cccaaacatt aaaatcgcag 3166081 gttattcaga cggttatgtt caagatcgca ccctagtggc aaaacaaatt gcaagagcaa 3166141 atcctgacat ggtattcgta gctttagggt atcctcatca agagaaattc attcataact 3166201 acagacactt gttccctaaa gccgtatcta taggtctagg aggaagcttt gatgtattta 3166261 gcggtaatgt caaacgggcc ccttcctgga tgatacgttt aaatttagaa tggttctacc 3166321 ggttaatctt gaatccatgg cgatggaaaa gaatgcttag catcccaaaa tatgctttaa 3166381 cggttttaaa agaagaaaaa aacaaaaaaa ctttctatcc aaagcctgaa aaagatcata 3166441 caaaacagat ttaaaaacaa aactttcaaa taaatggatg ataaaaatga aaataagatc 3166501 actactggcg aattgctatt tgtatttttt atcagcaatc gccttttttc tgcaatgggt 3166561 gaaacctgaa agcaaagtga ccctcctgat ctcattcgaa gcaaacgcaa aagcgattct 3166621 tgaggaatat gaacaaggac aatactctta taaacttaac atcctgtata cccagcaggc 3166681 ctctgctatt gccgagagct tcccgaatgt agatgcatat ttattacaag aaaaaaaccc 3166741 tatccatctc attaaagctg tatacctaat gtttaacagt aaagtgatca taacagataa 3166801 ttactttcta ttaacaagtg tgttaaataa gcggaagcaa acgaaatgta tccaagtatg 3166861 gcacgcaaat ggctcactca aaaaatttgg tttggaagac attacaaaca tgcaacggac 3166921 gaaaactgat attaaaaggt tccaaaaagt atacagttcg tatgattatt taactgttgg 3166981 ctcagaagag atggcaaata tcttcaagaa atcatttgga ataaaggata accaattatt 3167041 aaaaataggt gtacctttaa cagaccctta ttaccgagaa aacaagaaaa aaatttcaga 3167101 tactctaaac atacaaagaa aaaaaataat cctctatgca ccgacgttta gagattataa 3167161 tatgcaatca attcaattgc cttttacaga agaacaatta attcatcagt taaaagaaga 3167221 atatgtttta tttgttaagc tgcatcccgc cattcagaac aatattgata ttaaatattc 3167281 cagtgattat attaaagatg tttctaacta tgccttgttt gatctactca tggctgcaga 3167341 catattaatc actgactatt cttctgttcc ctttgaattt tcgattttaa ataaacccat 3167401 tcttttttat acttacgatt taaaacttta tcaacagaag cggggattgg ttgataatta 3167461 tctttccata atacctggaa gagcctgcta tgacagtgaa tcattaataa atgaaattca 3167521 aaccccattt aattattcca aaataaaagt tttttccgat agatggaata agtattctga 3167581 tgggaattca agccaaaatt tattgaattt catcgaaaat ttaataagct aaatgatgac 3167641 acttgttcaa aacagaacaa gtgttctttt ttctattgaa taccgaacgt atgtttgctt 3167701 taatgtaatt agttgcttat ggcagcaaat aataatagag gtggtaaatt tatgagaaaa 3167761 aaagaactgt ttgatttcac caacatcacg ccaaaattat ttactgaact acgtgtagca 3167821 gacaaaaccg tacttcaatc attcaatttc gatgagaaaa accaccaaat ttatacaacc 3167881 caagtcgcaa gtggattagg aaaagacaac acccaaagct atcgcataac tcgtctatct 3167941 cttgaaggtt tacaattaga cagcatgctg ttgaaacatg gaggtcatgg tacaaatatt 3168001 ggaattgaaa accgtaatgg caccatttat atttggtctc tatacgataa accaaacgaa 3168061 acagataaaa gtgaattagt ttgtttccca tataaagcag gcgcgacttt agatgaaaat 3168121 tctaaagaac ttcagcgatt ctcgaatatg cctttcgatc atagggttac acctgctctt 3168181 gatatgaaga atagacagtt ggcaattaga caatacgata caaaaaataa taataataaa 3168241 cagtgggtga caatctttaa cctggacgat gcaatagcaa ataaaaacaa tcctctttat 3168301 actattaaca ttcctgacga acttcattat ttacaaggtt tctttttaga tgacggttat 3168361 ttatattggt atacaggaga tacaaacagc aaaagctatc cgaatctcat aactgtattt 3168421 gattccgata ataaaatagt gctgcaaaaa gaaattactg ttggcaaaga cttgtccacc 3168481 agatatgaga ataacttccg tgaaccggaa gggatctgta tgtacaccaa tcctgaaact 3168541 ggggcaaaat cattaatggt gggaattaca agtggaaaag aaggaaatcg tataagcaga 3168601 atttatgcat accattctta tgaaaacttc atgaatcatg tacctatgct tcgatcccct 3168661 ttattaaaaa ccgtggggca ccaagataca cctccagaaa gatttcaacc atttattcaa 3168721 accttcattt tagagtataa tgctcaaaac aaaaaatgga tggttccgac ttcaggttat 3168781 ttaccatctt acacatcaaa tttagtccga aatattacta tcaatgcaga tggaaacttg 3168841 caagtcacat taaatgaacg ctatattagt ttactgcatc aatcgataga aggagatttc 3168901 cgcttaaaac aaaaggatat ccgaatggga tcctggtatt ttgccggcgg agaaaaatca 3168961 aatgtgcttg aaataggttt tatgaaaggg agtacaaaaa tcagacccga tgatgcagcc 3169021 atctcaaatg cttcaagaat gagtattttt atgattgttg cggacaagat tgaggtgtga 3169081 taatcaaata ggctgtagct atttaatagc tacagcctat ttgcaacttt ctaagttttt 3169141 tatcgatatt ccggaacatc aaaataaagt gtataaccgt ccagcaatga atacaggctg 3169201 tacatgcggt ttacttgttt gtacgcccag ccgatgtctg ttgcgtattg atgtgtcgct 3169261 gtagctgacc atctcatttt gtacagtgtg tcttgattgt aagctgtgtt gtggatatac 3169321 gatgagccta tgaatttagc tccgccgata atggccgctt ctggtgtgaa ccagccctgc 3169381 tcgtacgcat atttggctcc gtagtaattc ggattgctgt cgtatgctcc aattccatac 3169441 atgttgtata cggtttttcc gttataggtt aatccattgg ctaaagcgga tgtcccgttt 3169501 cctgtttcca gaagagcgtg tgagattaaa tacagttcgt tgatgctata ttgattggcg 3169561 gcatcgataa atgcctttgc tctccctgtc aggatgcctt tacccgcaag cactttctga 3169621 tttacctcag taacgctgag acccgctgtc tgtgacagct tgagaaattg gaagtagtat 3169681 ttgctgtctc tggaaaagtt attcggatcc acgtattgaa ctacttcatc actgcttgcg 3169741 tttcgccagc ccaaattgat cttagcccag ccgtttatct gtccgatgac tttcacttta 3169801 tcgccttttt taaactggcc gatcacgttt gtcgggctga cttccggcgt tgaccggata 3169861 tttagtacat cagccgtaac agttgatgtt gctgtattaa tgtacgtgag cgatacgtaa 3169921 gccgctccgt ctgtttgcgg acttactgtc atttgttttt ggaccatatc acgaagcgag 3169981 agattgtagt ttgttttcat gatttgcggg ccgtttttga tcttcacgat agatgatgtc 3170041 catccgtata attgttttag cttcgttgat gccgcagcag ctgtatcatt gcctgtgaac 3170101 tgctcattta cgctgatttt ataaagcgta ttgcttttcg ttgtatagct cggggttaca 3170161 cttttcgatt taagataggt taacccattg ttcaatgcgg ttttgctgct aagctgtgtt 3170221 gtcacgattt tgtattgtgt atatgcagtc tggcctgttt ttgatgttgt gactgcgata 3170281 tgattttgtt tgaaaaatgt taaaacgcgg tcaatctctt cttggctgat gatagcttca 3170341 gttgtgattt gatagctgct cgcagctgtc tgaccggttt tctggcttgc tactgatata 3170401 tgattcgatt tgaaaaacgt gagtgcctga ttgactttcg tttgatcaag cagagattcg 3170461 gttgtgattt taaacgtgtc agctatttgt tttttgacgg atttcgcaga agcacttagc 3170521 tgatttttct ttaatatgtt caaacccttt gtgacttttg cttgatctga tgtttcttct 3170581 gagatgagct gatattgatt ttctgctgtt gatccagctg ctgtttttgc agcttttact 3170641 tttttctgag caaagaaggc tgctgctttg tttgcttgct gctcgcctaa aatctttgcc 3170701 gtcgtgattt gataagctgc agacgttgtc gtttttttga cgctggatga cgtgtaatgc 3170761 cattttttct ttttaaagaa agtgtctatt ttttggagct gctgttttgt tatacccttc 3170821 atattcacgg tatatgatgt gctttttcca acctgttgat aactgccgga tacgccagtg 3170881 tttttcttga tttggctgat ggcgtccttt actgtactca gccctttgaa ataagctgat 3170941 tggacattgt atgactcaac ggttgttttt tgattgatgg acttgtagct gcctgtgatg 3171001 ccagtgctct gtttcagctg ctgcaataga gttttggcat tggcttcacc tgaaatggcg 3171061 gcagttgtga acgtataata ggcttgccct ttcactgttt cctttaatga tgcctgcagc 3171121 ccagattcct tttggaaggc gtttttgatc tgcgctgctc tgctgtctcc cacgattgtg 3171181 ccagactgaa tggttgtgac agacaccgtg tgtgtgatgg gctgatacga gcttttaatc 3171241 cccgtttgct tggccaggct ctggataagc gccttgactt ttgtctcatc agcaatgtct 3171301 gatgtcatga cgttcatata gggctgagct gctccgtaag cttttacagc gccagccact 3171361 cccgtctcct gtttcagctt tgctaggata gtgttggcct gtttttctcc ggagatggca 3171421 cctgacgaga tggtgacata tggctgtttg cttccaacag gacttgacgt tcctgtaatt 3171481 gatgtctgtt tggcgagtcc gctcagtatt gctttcgctt ctgattcgct atgaatgcct 3171541 gaggcggaaa tttggtaggt cgttgttgtg cctgaagcct gataggatgc atcccagcca 3171601 gtatcttttt ccagtttggc gacagcttgt gaggcttggc tttctgtact gaacgtattc 3171661 gacggctcta ctttatatag tgagtagtcg gtatacgcgg ctgcctgggc agaaccagac 3171721 atggcaaaaa aggcaaggga cgcggcggat agaagcatag gtgcgattag tctctttttc 3171781 attccttctc ctctttctta ttctatgagt atataaaact agtttattta tcggcacgcg 3171841 catgcttcat ttataggtga atcacttcca ttttctaata aaaaaactta acctcgaagt 3171901 gagattaagt ttaaatatga gacacgataa gggtacaagt tccttttatc gtaaaatcgg 3171961 gcatttgagc cggcaaaata aagtgatcac cttttttgag cggacatgtt ttgtcctcat 3172021 acttgagcaa accgcttcct tctatcacgc tgcaaatcag aaaggattca tcctgagcca 3172081 tttcagcttc gccattgatg tcccatttat aaaccgaaaa atattcccct tggacaaatg 3172141 ttttaatggt tattcctttt cttgattctg tcgattcatc tatatacccg tccacatggg 3172201 gaaccgtggc ggcattgacc gctttggcaa aatgaagctc tctcggactt ccgttgctat 3172261 caagacggtc ataatcgtac acccggtatg tggcatctga attttgctga gtctctaaaa 3172321 caagggcccc cttgcacaat gcgtgcagcg ttccgctcgg cacataatag aaatcacccg 3172381 gtttaatttt gattcttcgc agcaggccct cccagtcacc gctgttgatc attgtgacaa 3172441 gttcggtttt tgagcgggcc gtatgcccgt aaatgatttc tgcgttttcc ttacagtcga 3172501 taatgtacca gcattccgtc ttgccgagtt ctccctcttc gttttctccg gcatagtaat 3172561 catcagggtg aactttaatt gacgtatctt ccttcacatc cagcagcttt gtcagaagcg 3172621 gaaaccgatc cccctctacg ccgccgaata cttcacggtg ctcttcccaa agctcgatca 3172681 atgtctttcc tttatacggg ccatttgcaa cagtgctcgg tccttttgga tgagcggaaa 3172741 tggcccagca ttcccccgtt gattctgaag gaatactgta tccaaatcta tctcgtaaag 3172801 cggttccgcc ccagattttt tctttaaaca caggcgttag aaaaatcggt gattgcgtca 3172861 tgatccgtac ccctcccctg taaataactg atcatcattt tcccggtgcg cccctcttac 3172921 aaacgcccgt ataagctgcc tttttcctat gacaacatat gtacaaagca tcatcttttc 3172981 attacccctt caaagaaaac gcttcctatc tattatatca cgtcgaaaag aagctttgtt 3173041 tcagcctttt cctcgataag aataattctc cttttttgat acaaattaat aaaaaccgtc 3173101 aatatgttta agaaggagag aaactatgca aatcgactct gatctccaga acaatttaga 3173161 cacactgaaa aaaacattgg gacaaaacga cgatatgatg ttttatacat ttgctttcgg 3173221 agatagcaga caaaaggcgt gtttactgta tattgacggt ctgacagaga ataaaatgct 3173281 ggcgcaatac gtcatttctc ctttacaaaa agaggcgttg gcccataagg aatgctcgat 3173341 tgaagactta tccgcctttt ttttcggctt tcaccacagc gttgtttcta caatgaaaga 3173401 aatagagcag ctcgtttttt cagggcaagc cattttgctc gctgatggct atcgcggagg 3173461 attagctttc gacacaaagt cagtcgcaac acgcagtctt gatgaaccct cctccgaagt 3173521 cgtggaacgc ggccctaaaa taggatttat tgaaaagctg cggacaaaca cggcgctttt 3173581 gcgtgaacgg acgagtgatc ctaatctcgt catcaaagaa atgacactcg gaaaaaggac 3173641 caaaaagaaa atcgctgtcg cttatattca ggatatcgcc ccagattatg tcgtcaaaga 3173701 agtgtttaaa aggctgaaat cagtcaatat agataatttg ccggaatcgg ggacgcttga 3173761 acagctgatt gaagacgaac cattttcaat tttccccaca atattaagca cagaacgacc 3173821 ggaccgggtc gaaagttctc tattagaagg gcgagtgtcc atattagtgg atggtacgcc 3173881 gtttgctttg attgtaccgg ctacggttga cgaatttatt cattcgcccg atgattacag 3173941 ccagcgctgg atcccaatgt cacttgtacg ccttcttcgt tattccagca tcctgatcac 3174001 catttatttg cccggtctgt atatttctct cgtttctttt cacaccgggc tattgccgac 3174061 tagaatggcc atttccattg caggcagcag gcttaacgta ccattcccgc cttttgtaga 3174121 ggcctttatc atgatcttta cgatcgaatt gattcgagaa gccggattaa ggctgcctaa 3174181 gccgattgga cagacaattg gccttatcgg cggcgttgtc atcggacagg cagctgttca 3174241 ggcgcaaatt gtcagtgcgc ttatggtcat tgtcgtttct gtcacagcac tggcatcctt 3174301 taccgttcct tcatacgcct ataactttcc gctgcggatc attcggatcg gggttatgat 3174361 aagtgcaaca gcgcttggca tgtacggcgt tataatggtt tatctgtttg tgatcggcca 3174421 tctcatgcgc ctgaaaagct ttggccagga ttacattatc ccgatcatgg cgcagcctgg 3174481 acaggatttg aaagacacag tcatccgtat tcccacgatg tttttaaaaa gaagaccgac 3174541 acgaaacgat cccgaagata acatcagaca aaggtgatgg ctatgaggaa atcagagcat 3174601 aaactgacat ttatgcagac gctcattatg atcagcagca cattgattgg tgccggggtg 3174661 ctgacccttc cccgctcagc cgccgaaacc ggcagtccga gcggatggct aatgatactg 3174721 ctccagggcg ttatttttat tatcatcgtt ctgctttttt tgccttttct tcaaaaaaac 3174781 agcggaaaaa ctctttttaa gctcaacagc attgtagctg gaaaattcat cggctttcta 3174841 ttgaatttat atatctgtct atatttcatt gggattgttt gctttcaagc tcggattttg 3174901 ggagaggttg tcggattctt tttgttgaaa aatacgccaa tggcagttgt ggtgtttata 3174961 tttcttgcag ttgccatcta tcatgtaggc ggaggcgttt attcaattgc aaaagtatac 3175021 gcttatattt ttcctataac ccttattatt tttatgatgc ttctgatgtt cagctttcgc 3175081 ttgttccagc ttgattttat ccggccggta tttgaaggag gctatcaaag ctttttctct 3175141 ttattcccaa aaacattatt atatttctcc ggatttgaaa tcatttttta cctggtcccc 3175201 tttatgagag atccaaagca agtgaaaaag gctgttgctc tgggcatcgc gacttccaca 3175261 ttgttctaca gcattacttt gctcattgtg attggctgta tgactgtggc tgaggcaaaa 3175321 acggtgacat ggccgaccat ttcccttatt cacgcattag aggttccggg tatttttatt 3175381 gaacgatttg atttgttctt acagctgacc tggacagccc agcaatttgc ctgtatgctc 3175441 ggatccttta aaggcgccca tatcgggtta acggaaatct ttcatctaaa aaataaaaac 3175501 aatgcatggc tgctgactgc aatgctggct gcgacgtttt tcataacgat gtatcccaag 3175561 gacttgaatg acgtgtttta ttacgggacg cttcttggat atgctttctt aattgtgatt 3175621 acaattccat tcttcgtctg gtttttaagc tggatacaga aaaaaatagg gagggggcag 3175681 ctgcaatgaa aacagcatca aaattctccg tcatgttttt tatgctgctg gccctctgcg 3175741 gctgctggga tgtcaaagat atcgagcaac tatccttcgc cagagggctg gcgatcgatg 3175801 agacaaatga tcaccagtac aaactgacgt atcaaaatct tcttccccaa agcgaagaca 3175861 gccaagcatc cggaaaaccc gaatttgtta atgtaacgtc ccacgggaaa acgattctgg 3175921 aagcagtcag tgatgtatcc atcaaggacc ctcctgttta tagcgatcat ttaaaagtga 3175981 tccttctggg agaaaaactg atgaggaatc aaaatgtaga ccaagtcctc aaccacttta 3176041 tccgggatga tgagctgcgg cgaagcagct atttgatggc agccagaggg aatgcagctg 3176101 atgttttcac aaaaggaaac cccaatcagc agcagccgat gccctccgaa aaactgattg 3176161 atttgacaac tcacagcgga tataacggta agattatgat accgctgcgc atcggaagag 3176221 cttctgtcta ctctcagaac gggtacagtt atcttattca agccgtgaaa aacgaaaagg 3176281 gaaaagccaa gtatgacgga gcaggcatta tcaaaagggg cagcaataaa ctcgttgggt 3176341 ttctttcagc tgatgaaacc caaacactgt catgggtcat ggggacgatc caaggcggtg 3176401 tcatgccgac gacagataaa ggacatccga ttacgtttga aattaaaaag tcgaaaacga 3176461 aaattaagcc cgtcattgaa aacggaaagc ctgtctttca tatttctgtt aaaacgaagg 3176521 gcatcctgac agaagaccaa aacccgaatg aaaactcctt tagcaaaagt tatttgcaca 3176581 ggctggaaaa catttttgaa aaaaagcttg aacgagatgt aaagcaggtg atggataaac 3176641 tgcagcacga gtataaaacc gatccggtct ttttatcaga ccacataagg attcaacacc 3176701 ctgactactg gaataaagta aaagggcatt gggatgaaat attttctgag actgatttta 3176761 agtacgatat ttcttttaaa atcattaact ttggcacggt gggaaagtaa gcaatcaaaa 3176821 gggtgcgcat gatcgcgcac ccttttttat gttccgacag tctgctgttt tccggccgct 3176881 cctccctgtc cgtttttgtc ccgtaaatcc tgctcaattt cttcaaggct tcttcccttt 3176941 gtctctgtca ctttaaatcg gacaaataag aacgccatga taccgatcgc ggcataaatc 3177001 aggaataaat aactgattcc gatcgcttcc attaatattg gataggttaa tgaaacaatc 3177061 agtgtcccaa cgtgcaacat taaggtcgaa acaccggtcc cgattcctct gacgtgaagc 3177121 gggaacaatt caggaagcat cacccacaca accggtcccc agctgaccgc aaagacaacg 3177181 ataaacacgc ctaaacaaat gacggtcgtc catgaggcag ccggagtgtt atcgaaaaag 3177241 agatttacta aagcgagaac gatcaagctg atcaccatgc ccgcattccc gaatagcagt 3177301 aacggctttc ttccaatctt gtcgatgatt ttaatcgcta ctaatgtcat gagaacattg 3177361 actgtgccga ttccgaccgt gcctaaaatc gaagcggagt ttccgaatcc gacgtttgta 3177421 aaggtctttg gcgcatagta gatgatcgta ttcgttccga taaattgctg caaaaaagcg 3177481 agtcccaaac ctgcaataag cgctgggcgc acccatggat cgaacagctc cttcagaccg 3177541 ccttcatcct gcttttccgc ttcttttata tcatgtattt cctgatcaat atcttttgtg 3177601 ccacgcaatt tttcaagaat tttcttcgct ttgctttctt cgccattcgt gaacagccag 3177661 cgcgggctct ccggcataaa caaaatgcca ataagcaaga gcaatgacgg cacagcagcc 3177721 aatccaagca tccagcgcca cgcttcggca tcggcaaata tgtaattgac aatgtaagaa 3177781 agaaggatgc cgaccgtgat catcagctga ttcagtgatg acagcgcccc gcgtttatgt 3177841 tttggcgcca gttcagataa ataaaggggt acgattgtcg tcgatgttcc gactgcaagt 3177901 cccaaaatga tgcgaaacag caccatgact cctgtatttg gggccagtgc cacaccaaga 3177961 ccgcctatac aaaacagcag cgcggctgcc ataattgctt tttttcttcc gaaacggtca 3178021 gtcagcttgc cggccgctcc tgagcccaat atcgccccaa ccagcaagga gctgacaaca 3178081 agaccttctg taaacgcgtt taagcctaac tcctttttca taaataaaat agctccggaa 3178141 atcactccgg tatcatagcc atataacgcg cctccaagag ctccgaaaaa ataaagccat 3178201 atatttgact gctttttcat aaagatgact ccctttctcc atcagctgca atgacattgt 3178261 ctgtgggatt tttttagaaa tcttttagcc tctttttccg gccattaaac ctttttattt 3178321 ttctgatcat aagttttcca atcatttact tgtatttttt tcaatgtcgc cgaaacattt 3178381 tacctgctgc ggcgtccaat ataaggtgat tcagtacatt atcgttatca attttcaaaa 3178441 acaagaactt ataaatatag gaatatttat cgaaaaatgt ctttcgagta gttgccccat 3178501 ggcaaataga atggtacgct tcaaatatta aagaaacgtg aggtattgat atatggaaga 3178561 acgatcacag cgcagaaaga aaaaaagaaa actaaaaaaa tgggtgaaag ttgttgccgg 3178621 attaatggct tttttagtca ttgcggcagg ctctgtcggc gcctatgctt ttgtaaagct 3178681 gaacaatgct tctaaggaag ctcatgtcag ccttgcacgc ggagaacaat ctgtaaaacg 3178741 gatcaaagaa tttgatcctg gaaaagattc tttttctgta ttgctcttag gaattgatgc 3178801 cagggagaaa aacggcgaga ccgtcgatca ggcaagaagt gacgcgaatg tgctggttac 3178861 atttaatcgg aaagaaaaaa cagctaaaat gctgagcatt ccgcgtgacg cctatgtaaa 3178921 catcccaggc cacgggtatg ataaattcac acatgctcac gcttacggcg gcgttgactt 3178981 aactgtgaaa acagttgaag aaatgctgga tattccagtc gattatgtcg tagaaagcaa 3179041 tttcacggct tttgaagacg tcgtaaacga gttaaatggc gtcaaagtaa ctgtaaaaag 3179101 cgataaagtc attcagcaaa tcaaaaaaga tacaaaaggt aaagtcgttc ttcaaaaagg 3179161 aacacatacg cttgatgggg aagaagcgct cgcttacgta agaacacgta aagcggacag 3179221 tgacctttta cgcgggcaaa gacaaatgga agtgctgagc gccattatag ataaatcaaa 3179281 atcattgagc tcaattccgg cttatgatga tattgtggat acgatggggc aaaatttaaa 3179341 aatgaactta tctcttaaag atgccatcgg cctgttcccg ttcatcactt cattgaaatc 3179401 agttgagtct attcagctga cgggttatga ttatgaacct gccggagtct attatttcaa 3179461 attgaatcag caaaagctgc aggaagttaa aaaagagctg caaaacgatt taggtgtata 3179521 atgaacggga tggcgattac gccatcccgt tttacatatt tccttgttga aaattatcaa 3179581 agtaacgttt agccttaatt tatatggatt atgtttcaca ggcaagctga acatactaca 3179641 cgaagcagct tcatttttaa ggaggttccc ctacatatga aatgtattgc gattgatcta 3179701 gacggaacat tactgaataa agaaagcgtc atttctgcgg aaaacagaga ggcgatcaag 3179761 cgggccgttg atgccggcat cctcgtcacc atttgcacgg gaagagcgac atttgatgta 3179821 aaagcgctgc tggatgactt ggacatccct atcattgcag ctaatggcgg tacgatccac 3179881 gacacgggtt accgtttgat cagccggaca ttaatggatc aggaagccgg taaagcgatt 3179941 gctgattact tactttcaaa aaacatttac tttgaggtat atacagatga ccatctgctt 3180001 tctccttttg acggcgaagc taagctgcac gcggagcttg acattctaaa gagcgcaaac 3180061 ccaaacgagc agacggatga cttgtggcaa ggagccatga ctcaattcaa acagtttggc 3180121 attaaaccaa tccctcatat cgaatcggtt tttgacggcg gtgaaaacat ttataagctt 3180181 ctttgcttct cctttgatat ggacaagctg aaacaagcga aggaagaact gaagcatcat 3180241 aaaaaactgg cgcaaacctc ttcaggaaaa catattatcg aaatcctgcc ggcctcgtca 3180301 ggaaaaggac gcgcgttaac aaagctggct gacatatacg gaattgaaac acaggatatc 3180361 tatgcgatcg gcgatagtcc aaacgatttg tccatgtttg aagtcgccgg acaccgtatc 3180421 gccatggaaa atgcgattga tgaattaaaa gaaaaaagca cctttgtcac aaaaagcaat 3180481 gacgaaaatg gtgtggccta ctttatagac cagcttcttt cggggcaata tgcataaaga 3180541 aaagactcca gagattggag tctttttctt ttattgcacc cgtatacttc ctgcgtattt 3180601 atccttccaa tatgtgctcg tgttcatatt ggtaatggtc acgccgtttg ataatgtgac 3180661 atgaacaact tgtccgtttc cgatatagat ggagggattt aagcttgttg attgaaagaa 3180721 cacaatgtct cccggcttca ggtccgcctt ctcaatctta gttccggcat tgtactggct 3180781 tgttgcgtat cgaggcaggg aaataccggc tgctttctgg tatacatatt ggacaaatcc 3180841 agctgtatca aatcccgtct caggtgttac tccgccctgt ttgtaaggca cttctccgac 3180901 ataaagcgtc gcttcggaaa caatcggatt ttctttcggg attgtcaggt tgtcaaatcg 3180961 gcgaataccc gtcatcttcg atttccagta atcctctgac aaataggaaa tggttacttt 3181021 ttctgaccgg cttgcctgaa tgaacctgcc tgcgcccgca taaatgcctg catgtgaaat 3181081 tcccgtttta tacgtattgc tgaaatagac gacatcacca ggctttatgt tctgaggggc 3181141 taccttctcg cccactgccc actgctgttc ggctgatcgc ggtagataaa tgccgagtgc 3181201 ctgttgaaac acatattgca caagccccga gcaatcaaag ccctctgacg gcgtgcttcc 3181261 gccaaacaca tatgggacac cgatatattt ttcggcctcc tgaacgacag gaacatcagc 3181321 cgttgccgga tcggcagcga ttcgtctcgc cccgatataa gttccgctcc aatagctgct 3181381 ttttttgtaa ttggtgatga taaccccttt tgactgtgta ctgtgaacca tttggccgtc 3181441 tccgatataa agggcgtcat gtgtcggaac agtgccggtg cttccctctt tcttgaaaaa 3181501 caaaatatca cccggcttca ggttttccgg ttttacagct gttccgattt tatactggtc 3181561 gtttacagat ctcggcagat gaatatcagc cttactgaac acatattgta tcaatcctga 3181621 tggatcgaaa ccctctttcg gcgtttcccc gccatattta tactgatatc caagcaggtt 3181681 ttttgcttcg ctgacaatca attctgatga tgtatcagct tccgcaatct ccgcttttgt 3181741 cataattgga accaaaaaac aaatgataac cgccacaagc aaaaacttct tccagtttgc 3181801 cagtgtgttc acttttatta tctcctcctc tttttgcagt tttaacatcg gtattttttt 3181861 gaatatgtta agagactttt taatattttt acagaatgaa tatgctgggc aaataaaaag 3181921 agagtgtctc atcagacact ctcttttttg aattatttat tggcgtttac cggttcttcc 3181981 tgctgctgga ttttattcat ttccatatca atcttctgtt tttcctgatc tgtcagctga 3182041 tcattgaatt taaaagctga cataaacatg aacacgatgg ctacggcaac aaacggccag 3182101 atggctttga caaatttcat ctttatcact ccgattattt agattttagt ttgtcactat 3182161 gatcaatatc aaacgtcagt tttccgtctt ctactttcca agcgaaatta gagtctttcg 3182221 tcagttcgcg aataatggtt ttctgtttaa ggctgtcttt tttcacaggc gcaggtgtcg 3182281 cttcatggat atcgatcggt gtcacttcaa agcgtcctgt tccatttttc ttcaggtgat 3182341 actgaaccag tgcactgtct cttgttctcg tccagccttg gtcaaagaca aagttgccga 3182401 ggctgtagaa aatgacggtt ccgttatata cttcaatcgg ttctaagacg tgcgggtgat 3182461 ggccgacgat gatgtcagct cccgcatcag acatggctct tgcaagctgg cgctggcggt 3182521 catttggatc attgtcatac tcttgtcccc agtgtgactg cacaacaaca atgtccgcat 3182581 gttttttcgc ttctgaaatc atagggatga agatttcagg atctgcgggc agcacgcccg 3182641 gcgtattctt tttagccgcg aaacctttcc cggacacatc ggtaaagcca agcgtcgcaa 3182701 tcgttacccc gttgactttc tggtacgaaa ttttcttttt cgcatcactt aagctgtatc 3182761 ccgctccaac gatatcaaga ttttgcttcg caaattctcc aagcgtatct ttcatgccct 3182821 gaacgccgta atccattgcg tggttgttgg cgctgttgag aaccgtgaaa ttcatatcct 3182881 tcaagacttt cactgattcc ttattcgtct gcagatgaat ctctttatct gcttgtttat 3182941 aattcttttg ataggttacc gggttttcaa agtttcctgc tacataatcc gaggctctaa 3183001 agatcggttc aacatattga aaaatactgt ctgccccttt ttgctccgtt actttttcaa 3183061 catagcgtcc catcataata tcgcctacaa atgaggctga gagtacgtcg tcagaatacg 3183121 ttttgacctt cggcgtttcc gcttttcccg cccacatgaa agcgaacata aggacaaaaa 3183181 cgatcggaat ggcaataaat acgtgcttat tggttttctt tttttgctgt tttgtcagct 3183241 ttagcagctt ttcatgaaag ctcagttctt ttttcatcgt ttgacacacc ttacattaaa 3183301 ttaagtagta aacaaacatg atagcaaagg tcgctccgct caatagcagc gtgcttccga 3183361 acgtaatggt taaaccttgt ttctgaatgg tattggcaat taaacctggc acgatgatgc 3183421 cgattcctcg aaattctgcg atttcaaatg gtacaatcgg gtatagaaaa tcaaacgcga 3183481 tttttaggac gatccctgtt atcagcatgg cagcgaattt tctgcgtccg tacaaaatca 3183541 taaatttgga taaaccgtat ttcacaatga catacgtgag caagctcact agcaaaacaa 3183601 gtaaaataaa gaccggctga ttaaacacaa gtcctaaata tcccggtaca acaagtcctg 3183661 ccggcacgat ccctgttttt tccgcaaaaa ttaaactgag tagtacacct aaaattagtg 3183721 cgatgtataa atctgatccg aacatgtctg catttccccc tagcttacga gctgctttac 3183781 cttgtattcg tggatttttt caattaaagg ctctgcggca ccatgaatat tgccgacgcc 3183841 atatatgaca cggttgtgca ttcttttctt taacaattcc ataatttcat ctgttgactt 3183901 atactctaga tcatgcagtt tgtctgcagg aattttgcct tcttcgtagg cttttacgat 3183961 cggttctgtt gtttcaccga ttaagatcag ttcacttgct tcaatataag gcaatacgtc 3184021 atttgcgaat tgctgtgtcc gatcgacacg gtctgcgcgg cagttcatga tgatgatcgg 3184081 atcatcggtc gggtaaccga tttcttttac acgtttccat atattcaaag tagaagaagc 3184141 gtcgtttgcg gcaaacccat taacaaagtg cccaggctcg ctcggactga tcagcggaag 3184201 aattctcatt gctcccggat ctggcggcgc attcagcatt cccttaaatg ctgtttcttc 3184261 gtcaatgccg agtgcttgag ccacacccag cgccagagaa gcgttatcag ggaataccat 3184321 gtattcaaat ttacgtaaat actcatctgt aatttttgag ttatcagcaa tgatgacttt 3184381 tgtgtttcgt tcttttgctt tttgtttaaa gaactcggta tattcactat ctgtaatgac 3184441 aagatggcca ttataaggaa ttgtagcagt aaacgcttct gcaatttcat caagcgtcgg 3184501 ccccatgaca tccatatggt cttccaaaac attcacaatg acgccgatat tggcctgcag 3184561 aagttcttcc tgaaagatga tttgataatc tgggttaaca gccatgcatt cactgacaat 3184621 cgcgttagcc cctctttcta ctgtttctct catgacttct ttttgctctc cgatattcgg 3184681 cccctgaggt ttccgtttaa tcggcttttc ctccggtgtg tcccagtaaa tcattcttgc 3184741 atctgttcct gttgtttttc caacagtctt gtaaccggct tctattaata ttccggttgt 3184801 cagccttgtc acagtcgatt ttccgcggat gccgttaata ttcacccgaa cagggagggc 3184861 atcaatgttt ttctgatgtc gtcgtttttc taatattccg atgaccagta tgacagcaca 3184921 ggctataatg agtaaccaca ttgcttttcg acatctcctt ctatattgtt gtaaattcat 3184981 tcatcagtat atagaatcac tatgaattct caatcggcat tatgtaacat aatcttccct 3185041 aatcgactaa gccaaacttc tcttttgaaa gagattttat acctacaaac tgttttctat 3185101 ttttggaaaa cagcaggact tataccttat cactttttaa aaaaatcaaa gagaatgcgc 3185161 tttcattttt ctcctgatat ccttctggac gtatagtcac accctgctgt ttgtatttaa 3185221 tatgcatttc aaatcaatct ttttttcagc ctttgttatc aagcatttcc tgctatcatg 3185281 cgtgtttccg gttcttatga acacaaaata attttatcct gtttcttaag gacaaggtca 3185341 taatgtcatc ctttctgcat ggaataagca atatgaggcc cattccaaaa tgactaagga 3185401 ggttcgagat gaaaacgcta aacatacgag tccgaattct ctaacataat taaacatttt 3185461 ctgggatgat agtcttttct gtttctcccc atttacaggt ctaaacgcat gactttgaaa 3185521 caattttaat aaaacttaat atttgttcaa gaaatcttca tccatatttg tgaagacttt 3185581 gtcaaaaaaa gagtgaaaac cttaaatttt tcaattatat atacaattta caattagatt 3185641 tcttttgata tttttattgc taacttcgga ttgttcatga taatctatct atgtaaacgg 3185701 ttacataaac aaggaggagc tgttttggct acaattaaag atgtcgccgg agcggcgggc 3185761 gtttcagttg cgacggtttc ccgcaacctg aatgataacg gctatgtaca cgaagaaacg 3185821 cgaacgcgtg tcatagcggc gatggcgaag ctgaactatt acccgaatga agtcgccaga 3185881 tctctatata aaagagaatc ccgactgatc ggacttttgc tcccggatat cacaaaccct 3185941 ttcttccccc agcttgcccg cggtgcggag gatgaattga accgggaagg ctatcgcctt 3186001 attttcggca acagtgacga ggaattgaaa aaagaacttg aataccttca aacctttaag 3186061 caaaatcatg tcgcaggcat tattgccgca acgaattacc cggatctcga ggaatacagc 3186121 ggcatgaatt atccagttgt ttttctggac agaacgcttg aaggggctcc ttctgtgtcc 3186181 agtgacggct atacaggagt aaagttagcc gcccaggcta tcattcacgg aaaaagccag 3186241 cgcattacgc tcttgagagg acccgctcac ctgccgaccg ctcaagaccg atttaacggc 3186301 gctttggaaa tcttaaagca ggctgaagtt gattttcagg tcattgagac agcttcattt 3186361 tcaattaaag atgcacaatc gatggcgaag gagctgtttg cctcttatcc agcgacagat 3186421 ggtgtgatcg cgagtaatga tattcaagcc gctgccgttt tacatgaagc attgcggcgc 3186481 ggaaaaaacg tgccggagga cattcaaatt atcggctatg atgacattcc gcaaagcgga 3186541 cttctgttcc cgccactttc tacaattaaa cagcccgcat atgatatggg gaaagaagct 3186601 gccaaactgc ttttgggtat cattaaaaaa cagccgctgg cagaaacggc aattcaaatg 3186661 cctgtcacct atataggaag aaagacgaca agaaaggaag attaagatgc gtaatatttg 3186721 tgtgattggt agctgttcta tggatttagt ggtcacctcg gacaaacgcc caaaagccgg 3186781 tgaaacggtt cttggcacgt catttcagac tgtgccgggc ggcaaaggag caaatcaggc 3186841 cgttgccgca gccagacttg gggcgcaagt gtttatggtc ggcaaagttg gagacgatca 3186901 ttatggaaca gctattttga ataatctcaa agctaacggc gttcgcactg attatatgga 3186961 accggttaca catacggaaa gcggaaccgc tcatattgtg cttgctgaag gcgacaacag 3187021 cattgtcgtt gtcaaaggcg cgaacgatga catcacccca gcgtatgcgt taaacgcgct 3187081 cgaacagatt gaaaaggtcg atatggtgct gattcagcag gaaatcccag aagaaacggt 3187141 tgatgaggtg tgcaaatact gccattctca cgatatcccg atcatactaa acccagcacc 3187201 ggcccgcccg ctcaagcagg aaacaattga tcacgctacc tatctgacgc cgaatgaaca 3187261 cgaggcttcg attttattcc ctgagcttac catttccgaa gctctggcgc tttatccggc 3187321 aaagctcttt attacggaag gaaaacaagg cgtccgctat tcggctggca gcaaagaggt 3187381 gctcatcccg tccttccctg tagaacccgt tgatacaacc ggagccggtg atacgtttaa 3187441 cgcagcattt gccgtggccc tggctgaggg aaaagacatt gaagccgcat tgcggtttgc 3187501 caatcgtgcc gcttcccttt ctgtctgctc cttcggtgcc caaggcggaa tgccgacaag 3187561 aaatgaagta gaggagctgc tgtcatgaaa aaacacggta tactgaacag ccatcttgcc 3187621 aagattttag ccgaccttgg ccacactgat aaaattgtca tcgcggatgc cggactgccg 3187681 gttcctgacg gcgttttgaa aattgatctt tcactgaagc cgggccttcc ggctttccaa 3187741 gatacagcgg cagtactggc tgaggaaatg gcggtcgaaa aagtcattgc tgcagctgaa 3187801 ataaaagcat ccaatcagga gaatgcgaaa tttctagaaa atcttttctc tgaacaagag 3187861 attgaatacc tttctcacga ggagtttaag ctgctgacaa aagatgcaaa ggcagtcata 3187921 agaacaggag aattcacacc atatgccaac tgcatcctgc aggcaggtgt acttttctag 3187981 aaaggaagat gaaacatgca gattgaaatg aaagacattc ataaaacatt cggaaaaaat 3188041 caggtgctgt caggcgtttc ctttcagctc atgcctggcg aggttcacgc attaatggga 3188101 gaaaacggcg ccggcaagtc cacgcttatg aacattttga caggcctgca caaagcagat 3188161 aaaggtcaaa tcagcataaa cggaaacgaa acgtattttt ccaatccgaa agaagcggaa 3188221 cagcatggaa tagcctttat ccatcaggaa ttgaatatct ggccggaaat gaccgttctt 3188281 gagaatctat ttatcggtaa agagatatcc tccaagctgg gcgttttaca aacaagaaaa 3188341 atgaaagcgc tagcaaaaga gcaatttgac aaactttccg tctctctttc tcttgatcaa 3188401 gaagccggcg aatgttccgt cggacagcag caaatgatcg aaattgcaaa agcgcttatg 3188461 acaaatgccg aggtaatcat tatggatgaa ccgaccgcag cgttgactga acgtgaaatc 3188521 agcaagctct ttgaggtcat tacagcgtta aaaaagaacg gcgtctccat tgtctatatt 3188581 tcgcatcgca tggaagaaat ttttgcgatt tgcgacagaa ttaccatcat gcgtgacgga 3188641 aaaacggtag atacaacaaa catctcagaa actgattttg atgaagtcgt caaaaaaatg 3188701 gtcggacggg agctgactga acgatatcca aaacgcactc cttctctcgg tgacaaagta 3188761 ttcgaggtga aaaatgcttc cgtaaaaggg agttttgagg acgtcagctt ttatgtgcgt 3188821 tccggtgaga tcgtcggtgt ttcaggatta atgggagccg gccggacaga aatgatgaga 3188881 gcgctgttcg gcgttgacag gctggacacg ggtgagatat ggatcgctgg gaaaaaaacg 3188941 gctattaaga acccgcagga agccgtgaaa aaaggtctcg gctttattac agagaatcgc 3189001 aaggatgaag ggctcctgct cgacacctcg atccgcgaaa atattgccct gcccaatctg 3189061 tccagcttct caccaaaggg tctcattgat cataagcggg aggctgaatt tgtcgatctg 3189121 ttaatcaagc gcctcactat caaaacagca tcaccggaaa cgcacgcacg ccatttatca 3189181 ggaggaaacc agcaaaaagt ggtgatagcc aagtggatcg gcatcggacc gaaagtgctt 3189241 atcttggatg agccaaccag aggtgtggat gttggcgcca aacgagagat ttatacgctg 3189301 atgaatgagc tgaccgaacg cggtgtcgct atcatcatgg tgtcatcaga gcttcctgaa 3189361 attctgggaa tgagcgatcg gattatcgtt gtccatgaag gcagaatcag cggcgaaatc 3189421 catgcgcgag aagcaacaca agaacgaatt atgacacttg ccacgggagg gcggtaatat 3189481 gaaaacggaa caactgcaaa cagaacaaaa acggattcac ttcgacggag tcatgcaaaa 3189541 actcggcccg tttcttggtt tatttattct cgttatcatt gtatctattt taaatcccag 3189601 ctttcttgaa ccgctgaata ttttaaacct gcttcgccag gtcgccatta acggattaat 3189661 cgcgttcggg atgacctttg ttattttgac aggcggcatt gatctttctg ttggcgctat 3189721 tcttgccctg tccagtgctt tagttgcggg gatgattgtg tccggtgtcg atccggttct 3189781 cgcgatcatc cttggctgta tcattggtgc cgtactaggc atgatcaacg gattattgat 3189841 tactaaagga aaaatggcgc cctttatcgc cacgcttgcg accatgactg tgtttcgcgg 3189901 actgacgcta gtgtatacag atggaaatcc gattaccgga cttggcacaa actacggttt 3189961 tcagatgttc ggacgcggtt actttttagg cattcctgta ccggcaatta cgatggttct 3190021 tgcctttgtc atcctttggg tgcttcttca taaaacacca ttcggacgcc gaacgtacgc 3190081 tatcggcggc aacgaaaaag ccgcgctcat ttcaggcatc aaagtgacgc gcgtgaaagt 3190141 gatgatctat tctttagccg ggcttttatc cgctcttgca ggtgccatat tgacttcccg 3190201 cctgcattcg gcccagccga ctgcgggaga atcgtacgaa cttgatgcta tcgcggcagt 3190261 cgtcttagga gggacaagtc tttccggcgg ccgaggacgc attgtcggca cgttaatcgg 3190321 ggtgctgatc atcggcacac ttaataacgg acttaatctg cttggcgtct catcatttta 3190381 tcagctggtt gtcaaaggga ttgttatctt aattgcggta ttgttagacc gcaagaagtc 3190441 agcttaggag ggttttacat gaaaaaggct gtatccgtca ttttaacgtt atcattattt 3190501 ttgttaaccg cctgttcgct tgagcctccc caatgggcaa agccatcaaa ctcggggaac 3190561 aaaaaggaat tcaccattgg cttgtccgtc tcaacgctta ataatccttt ttttgtctca 3190621 ttaaaaaagg gtatcgaaaa agaagctaaa aaacggggaa tgaaagtcat cattgttgat 3190681 gcacaaaatg attcatcgaa acagacgagt gacgtggaag atttaattca gcaaggtgtt 3190741 gatgcattat taatcaaccc gactgattct tcggcgatct caacggcagt agaatctgca 3190801 aacgcagtcg gtgtgcccgt cgtaacaatc gatcgatctg cggaacaagg aaaagttgaa 3190861 accctcgttg cttccgataa tgtaaaaggc ggtgaaatgg ccgcggcgtt tattgccgac 3190921 aaacttggaa aaggagcaaa ggtggcagag cttgaaggcg tccccggcgc atctgccaca 3190981 cgggaacgcg gctcaggatt ccataacatc gcagaccaaa agctccaagt tgtcacaaaa 3191041 caatcagctg actttgaccg cacgaaaggc ctgactgtca tggaaaacct gctgcaggga 3191101 catcctgata tccaagctgt ttttgctcac aacgatgaaa tggcgctcgg tgctctcgag 3191161 gcaattaaca gctcggggaa agacatattg gtgatcggtt ttgacggcaa taaagatgcg 3191221 ctcgcttcca ttaaagacag aaagctgtca gccaccgtcg ctcagcagcc tgaattaatc 3191281 ggtaaattgg ctacagaagc agcagatgat attttgcacg ggaaaaaagt gcaaaaaaca 3191341 atatccgcgc ctctcaaact agaaacacaa aaataattgt ctgatgttta ggaacctgcg 3191401 ataacgtgaa tagagatata gaatgaatta tttctcttac gtgaggagag gaacggcatg 3191461 aacaaaccaa caaaactatt ttcaacatta gcacttgcgg ctggaatgac tgcggcggct 3191521 gctggcggcg ctggcacgat ccatgctcaa cagccagaaa caacggtaag cattgatgat 3191581 ttatacagtt atccgattga ttcttatttg gtatcagcag aggctctaaa tgtcagaacg 3191641 aagccttccg catcaagcca gaaagccgat acgctgcact taggagatag cctaaagctg 3191701 atttccttct caaatgctga ctgggcaaag gttaagtata aaaatggaaa aacaggattt 3191761 gtatccactc attacattgt taaagcagcg acaacggtaa aaaccaaaac aaaaacaaaa 3191821 gtgtatacat ccgctgacgg aaagagcatt aagactcttc cagcagacac aagcgtttct 3191881 tttttaggct ggagtaaaac gaataaaggc ggttttgatt ttgattgggt attcgttgat 3191941 tacggcggta cgacaggtta tatgaaaaca aaggatttac acatgacaaa ataactgaga 3192001 gggattccgc ataaatgcgg aatccctttt attatgaatt gatttgtcac attcccaaga 3192061 tatttctcag gaaatattgt cgtatgctgt gtcgaaacct tacatgatca tcgacatttt 3192121 tgttcacgct aaaaagcgga ggtgtaaata tggatcaatt tgaagcagca tatgaatcgt 3192181 ataaagcccg gcaaacaact gccgatcaag aaaatgttcc atctggaaaa gaagaaatta 3192241 ttgcggttag aagaaatgag gaagacaata ttatcgcagt gaaaaccaat acaggaagag 3192301 agctcgacta ccctactgcg ctgtcagaag caaaatcagg aaaactcgct catgttgatg 3192361 tcttccataa atacgggcgt gacattttgc gaagtgaacc ggacggcatc aaggaaaata 3192421 acctgtctga gctgccggat ttttaaacaa atacagccct gccgtatgtt ggacagggct 3192481 gtattttaaa caaaaggctg ctggatgtat tcggctaacc gttttgcact gtgagaaata 3192541 tcctctgcag ctgcataatt cacgccatag aacacatatg gaggcagata cttcatgccg 3192601 atcagattac tcgtggcctg aaatggtttc aatagctcac tgatcgagta atgatttgct 3192661 ccgcccgctt gatatttttc cgcttcgctc cctgttgata cagccagcat cagctccttg 3192721 ccatgcaagg catttccttc tgaaccaaaa gcccagccat aagtcagcac aagatcctgc 3192781 cattttttca agagcggcgg agagctgtac caatatagcg ggaattgaaa gacaatccga 3192841 tcgtattcct cgcacagctg ctgttccttc gcaacatcta tcgcttcatc cgggtattcc 3192901 ttataaagat cccgtactgt gatattgtca tgtttactca attcctcagc ccacgcctta 3192961 ttaacaactg aggtctccat atgaggatgc actgccaaaa ccaatatttt catcagacca 3193021 cacctttact gttttgatgt tattttatct aaaatcagga aaagagccaa ataaaaagaa 3193081 agccctgcta aaaggggctt tctttttttc ttttattcag ggcttccttc agttgtttcg 3193141 atatctttcg caaaatcagg gttatccaga ttcgcattaa agaaatccgc tgtgttcgga 3193201 agtctgagat tcatgttcat tttttgagaa atcgtaaccg tgcaatcctc aagcacatag 3193261 tcaaaaacgt gtccgcctga attgcgtcct tcgtcaatga agtgcaggtg atagccagaa 3193321 acggcgattc cgtttgcata agctggtgtc aagaaaccta caatcgttcc tctcacgttg 3193381 tcgaagttga aaatcggctg tgttttgacc gcttcaacca ttggcacgta aggtttttct 3193441 tgaagttcta ctgttcttgt ctgcaccttt ttaaacaatc cgtcaatgcg aattgcataa 3193501 aataagtttc tgcttggcag catgctgttg atctcttttt caaagtcttc gcgtgtcatt 3193561 ttcgcatcaa ttttgtgcgt catgtccggt gtaaagaacg taaatgaaca gaacggtgaa 3193621 cggtctccat tttggaccgg tgtcgcggtt ccgtctgagc gaagacggta aaattcgccg 3193681 tcaaacccaa tcagctctcc gtcaagcttg ttaaaggttc cgataccgaa gtctccatat 3193741 ttcggaatct ctgacagttc aaaatctccg tcatatactc cgtctaatag agaagtcatt 3193801 gttgatactt gataaatctg gctcacaggc tgatcttttt gaccacggct gagcacttga 3193861 atgttgcttt ctcgtttcat atttcccttc actcctttta tttagtgctg ttcataaaac 3193921 agtgtcgtga tgcgcagagt gctagagagc tttcgttttc atgagttccc cgaattcttt 3193981 cggaagcttg tcacttgcta aattaatgtt atcactgtag tcaaccggga catcgatgat 3194041 gacaggacct tcagcgttca tgccttgacg cagaacatct gccagctggt ctggtgattc 3194101 tacgcgcaag ccagttgctc cgaagctttc cgcatatttc acgatatcga tatttccgaa 3194161 atcgaccgca gatgtacggt tatatttttt caattgctgg aatgcaacca tgtcatatgt 3194221 gctgtcgttc catacaatgt gtacaattgg tgcttttagt cgaactgctg tctctaattc 3194281 cattgctgag aataagaaac cgccgtcacc agagacagaa accacttttt ctcccggttt 3194341 caccaatgaa gcgccgattg cccaaggaag cgcaacgccg agtgtttgca taccgttact 3194401 gatcattaat gttaacggct cgtagctgcg gaaataacgt gacatccaaa tggcgtgcga 3194461 accgatatcg caagttactg taacatgatc atcgactgca ttacgcaact ctttaacgat 3194521 ttcaagaggg tgcgctctgt ctgatttcca atctgcaggc acctgctcac cttcatgcat 3194581 atattgtttt aaatcagaaa ggattttctg ctcacgctct gcaaattcca ctttcacagc 3194641 atcgtgttcg atatgattga tcgtggacgg aatgtcaccg atcaattcaa gatcaggctg 3194701 gtaagcatga tcaatgtcag cgataatctc gtctaaatgg ataattgtcc ggtctccatt 3194761 gatattccag aatttcggat catattcaat cgggtcatag ccgatcgtca gaacaacatc 3194821 tgcctgctct agcagtaaat cgccaggctg gttgcggaac aaaccgatac ggccaaaata 3194881 ttgatcctct aaatctctag aaagggtacc ggcagcttga tatgtttcaa caaatggaag 3194941 ctgaaccttt ttcaaaagct tgcgaaccgc tttaattgct tccggtcttc cgcctttcat 3195001 gccgaccaaa acgacaggaa gttttgctgt ttggattttt gctatggccg cactgattgc 3195061 atcatctgct gcaggaccga gttttggcgc tgcaacagca cgcacgtttt tcgtatttgt 3195121 gacttcattc acaacatctt gcggaaagct cacaaaagcg gccccagcct gccctgctga 3195181 cgctatccta aatgcatttg taacagcttc cggtatattt tttacatctt gaacttctac 3195241 actgtatttt gtaatcggct ggaatagcgc cgcattatcc aaagattgat gtgtccgttt 3195301 taaacgatct gcacggatca cgtttccagc aagcgcaacg acagggtctc cttcagtgtt 3195361 cgctgtcagc aggcctgttg ccaagttaga ggcacccggt cctgatgtga ctaacacgac 3195421 tcccggtttt ccagttaaac ggccgactgc ttgggccatg aatgctgcgt tttgttcgtg 3195481 ccgggcaacg ataatttcag gtcctttatc ttgtaaagcg tcaaataccg catcaatttt 3195541 tgcacctgga atgccaaata catgtgtgac accttgctcc actaagcaat caacaacaag 3195601 ctccgcccct ctgtttttca caagggattt ttgttctttt gttgcttttg tcaacaccct 3195661 cactccttat tatgcatttt aaacgtaaaa ttttaaatat cttgtgataa gtttcactat 3195721 acactctttg gaaattgacc tccaatatcg attcgcctta tgattaatat gtaatacgaa 3195781 ttattaacct atggaaagga atgcatattg aatggagctt cgccatcttc aatactttat 3195841 cgcagtagcc gaagagcttc atttcggaaa ggctgcccgg cggctgaaca tgacgcagcc 3195901 tcctctcagc cagcagatca aacagctgga ggaagaagtc ggagttacgc ttctgaaaag 3195961 gacaaaacga tttgtcgagc ttaccgcagc aggagaaatc tttttaaatc attgccgcat 3196021 ggcattgatg caaatcggac aaggaattga actggcacag cggacggccc gcggcgagca 3196081 aggccttctc gtaatcggtt ttgtcggatc agctacatat gaatttctgc cgccgattgt 3196141 ccgggaatat cgtaaaaaat tcccatctgt gaaaatagaa ctgcgtgaaa tatcctcgtc 3196201 taggcagcag gaggagctac taaagggcaa cattgatatt ggtatacttc atcctccctt 3196261 acagcataca gctttacata tcgaaaccgc ccaaagcagc ccttgtgttt tagctttgcc 3196321 taagcaacac ccattgactt ctaaggaatc aattacgatt gaggatttaa gagatgaacc 3196381 aattattact gttgctaaag aagcatggcc tactctatac atggatttta ttcagttctg 3196441 tgaacaagcg ggcttcagac ccaacattgt ccaggaagcc acagaatatc aaatggtgat 3196501 tggtttagtc agtgccggaa ttggtatgac atttgttcct tcctcggcca aaaaattatt 3196561 taatttggat gttacttatc gaaaaatgga ccaaatacag cttaatgcag aatgggttat 3196621 cgcttaccgc aaagacaatc ataatccgct tataaagcat tttattcata tttcaaattg 3196681 tcagcagaca agaactaaag agagtgatgc aggtacatga acaatacttg caatctcttt 3196741 tttcttttgg gattcttatg gaatttttat taatttaata taatcgctta gtacaacttt 3196801 atatcagtat acgtatacat acagtacaaa tagttggcaa ggacatcagt aagcgcagga 3196861 cattagtttg attttaaaaa tgaaagatag agaggtgaag taaattattg agttcaccgg 3196921 catattcaca ttgctcgctt ttttcgtaac aatgattttt attttctgga gaccaaaagg 3196981 actaaatgaa gctatccccg ccacatttgg cgctttaatg gttttattgt gcggaagtgt 3197041 gtcattggca gacttagggg aaatcggaac aaaagtcacg ggtgcatcgg ttacaatcct 3197101 tgccactatg attatggcca ttgcactaga aagctttggt ttcttttatt gggtggctgc 3197161 aaaactgctc caacaatcca agggttcagg catcaagctt ttttggctaa ccaatttgct 3197221 ctgctttctc atgaccattt tccttaataa tgatgggagc attttgatca caactccaat 3197281 ccttttgctt gtactaaaat atttaggttt aaaaaaacat caaaaagccc catatttatt 3197341 aagcggtgtt ttaatagcca cagcctctag cgcaccgatt ggcgtaagta atattgttaa 3197401 tttaatttct ctcaaaatca ttggaatgga tctatatctt cacaccgcca tgatgtttgt 3197461 ccctagtatg atgggactca tttttatgac ttgtctactg tttatgttct tttataaacg 3197521 tcttcccaaa agcctgccag atataccggg ccattttcag tctctgcggc atagaaggta 3197581 ccatcctctt cattcgccat cagctccttt accagaacga aatcaaacaa aaatcatgtt 3197641 gtttgtgctt gcatttgttt ttctcgtcag aatgagtcta tttgcagcat catataccgg 3197701 tatttctgtt cctctagtcg ctgtcatcgg atcttttatc ctgttgagct ggagatggat 3197761 ttatttcaaa acctccccaa gagacttgtt atataaatcg ccttggcaca tttttatatt 3197821 cgcttttact atgtatgtct taatttatgg tctgcataat attggattca cagagttact 3197881 tgtgagttat tttgaacctg tggtttctgg aagcctcgcc catgcaactt tcgcatcagg 3197941 tatctctact tcagtttttt ctaatctctt taacaaccat ccagcgttaa tgatcagtac 3198001 ttttacctta actgaaatga ccctgaatcc ttcaacaaca aaaatcatct acttggcaaa 3198061 tattatcggc agtgatatcg gttcattatt attacctatg ggaaccttag caacgcttat 3198121 ttggatgcat atattaaaac agcatgatga aagtatttca tggggcgaat atataaaaac 3198181 gaccattatc atcattccgc tgactgttct ttttacgtta acatgtttat atttttggat 3198241 cagttggtta tttctttagc acagtatgaa acgaaaaact gccttctgct tttcaagagg 3198301 gcagttttgt atacactagg gaagatgcat tgtctttaga tgatttaact tccaaatgac 3198361 tggctctcca cttgcgttaa taagctcaat gatattatta gagacaccct ttaatagtcc 3198421 gactttttct ggcacctctc ccatatcaaa tatgaccaat tcaccaatat tttttttgat 3198481 ctgctcctca aaattacgca caagaggaac tttggaaggc acgaccggca attgtgagtt 3198541 gtcaagagta tacggtgttt gttcagttga ataaggggta aaccatttta aatgatgcat 3198601 agatataaaa agtattttaa atacgggtga gaaaaataca atataatcgt ttaaaacatt 3198661 tgtaacatat ccatggatcg atcgaccccc agttacataa acttcaataa actggccttt 3198721 gaccttgttt aatgtatttc tatatgaaaa agcttgagtt tctgcctcta tcattggatc 3198781 ttccggattg atcaaaaatg gcttctcagt actggtcact attttcgcct tgtttatttg 3198841 atgaagatgc aacaagggaa tataaagata attgcagcca tcaaaaataa caaaaatatc 3198901 ctgtccgata tctatgaggg tgccgacaaa ccttgtatct cctgaaatga caacctcaac 3198961 atctgtgtta aggaattgat tcaaaccttt cacgattctc ctcctttaac tgaaaaaggg 3199021 catcacttta tctgatgctc ctccattatc tattaaaatt tacgtttcca gtgatagtct 3199081 atcgttctga caatcgtttc atagctataa tcttcctttt gttttcctga actttttatt 3199141 gaacttgaat agcctggtga tcttgatgat tgataatctg aagatcttgg tgatcgttta 3199201 gatgattttg atgattgata atctgaagat tttaatgatc gtttagatga ttttgaagaa 3199261 ctttttgaac gtgacgaacg gccagatttg gatgattgat aatccgaaga ttttagtgat 3199321 cgtttagatg attttgaaga actttttgaa cgtgacgaac gaccagattt ggatgattga 3199381 tcatctgaag attttagtga tcgtttagat gattttgatg agctatatga ttttgaagaa 3199441 atgaacgaat tgctgtcctt atcattattg tcttcctggt tttgttcatt tttttgatcc 3199501 tcttttttgt acgacccttt tggacctaag ctgatgcttt ttatgtgaaa aggatagatg 3199561 cgaagcacct cttgattttt cactatagta taatggccgt cggcattatc tacaaggata 3199621 ccctcaatgg cttccggacc tccacgatta attgaaaccc atttatgagt cagactctta 3199681 aaaacctcgc ttaaatcatc agcttccaaa actccaactg gcgtctgctc ttctattttc 3199741 aaatcaggct cgtgtttact tatacttttg atgtgatgga tattaaaata cactacccca 3199801 tcctcatttg tgtttaacgc agcgtaatca tctcccagcc agaccaatct tcctttttta 3199861 gattccggac ccccttggtt aaattgaact gattggttta ttaaatgtcc gattaagcta 3199921 tgaaaatcat cagcatcgag catttcctca gtctcaattg ttgtggtgct attattggta 3199981 tcctcagtaa tacttttcac atgctccaac tgataataaa ttattttttt ttcagcttgt 3200041 aaagctatat aatctgattt tacagctgtt aattttcctt ttttagattc cggacctcca 3200101 cgatatacag taacaatttt atctttcatt gagtgcaaaa agttataata cgatatttca 3200161 ttatttgaat gatatttcat tctcctcttg ctcattcaaa ttcctcctag tcacttatac 3200221 atagatgata aacatactgc atatatacgt gtcacattta tttgttgaac taattcaata 3200281 gcctaattgt cgctttttcc gcgaataccc attttcacgc attcataaaa tacttaaatg 3200341 atctttgagg tattgtgaac ggtttttaat atactcgcag atcacatccg gctcacggtc 3200401 aaaacgctca atatcattct ttttatacgg gtccatgagg acaaacggcc taatccgttc 3200461 atacatcgcc atgattttcg gttccatata ttctattgta aaaagagatt ggagcgtttt 3200521 ttctaacagg cgcttgtagg acttgcgaaa ctcggattca tccaatatcc gggcggttag 3200581 tgtattaaat ccttgaattc ttacataatc ggcagccatc cgctctccat ggatatccct 3200641 gccccaagtc gcatcataat cccaaggaat cacctcaaat aatccggttt ccccgcttct 3200701 gtataatgcg tagttgtgga caaacccgtc atagttcgag gtgaatacaa taccagcaag 3200761 ccagcgcaaa tacttatcga catccacgtg ttttgtcact tctgacttaa actgagcttt 3200821 agggaccgta ttaattttaa aaatcatatc ttgtaaataa aaatcatctt cctcagtccc 3200881 tgttttcttt tcatatccaa gctccagcga tgttttcgtt tccctttcta aatcgctcat 3200941 cagagaaaag ttggcatcat catccaccgc ataaaaaatc gcgccatcag ccagcttcct 3201001 tttcgccaaa taatattcat ctacggattc aagttcaaga taaacccctt cattcttccc 3201061 attcatcttt acaaacgcaa actctgcctt tggagacagt gtccctagct ccgagaaaaa 3201121 atccagagac aatttgtttc tcatcaagga agggtcttta tactccgcat ttaagtgaat 3201181 ctctcgcgcg ccgcggaatg ttttcggctg ataaaaggaa atatggtatg acttcttttt 3201241 gaagtctctg atatgtgatc cccgataagc gatatcaata tccagccttt tttgatttac 3201301 cttcatcaca gctggcaccg gatcatcgtc ccatatatcc ttttttaatt cacgcaagtc 3201361 ttttggatga acaaacagct gataaagcgg taaattggat tgattcttca tccataatcc 3201421 tccttacaaa ttttaggctt ttatttttat aagatctcag cggaacactt atacactttt 3201481 taaaaccgcg cgtactatga gggtagtaag gatcttcatc cttaacatat ttttaaaagg 3201541 aggatttcaa attgggccac tattcccatt ctgacatcga agaagcggtg aaatccgcaa 3201601 aaaaagaagg tttaaaggat tatttatacc aagagcctca tggaaaaaaa cgcagtcata 3201661 aaaagtcgca ccgcactcac aaaaaatctc gcagccataa aaaatcatac tgctctcaca 3201721 aaaaatctcg cagtcacaaa aaatcattct gttctcacaa aaaatctcgc agccacaaaa 3201781 aatcatactg ctctcacaag aaatctcgca gccacaaaaa atcgtaccgt tctcacaaaa 3201841 aatctcgcag ctataaaaaa tcttaccgtt cttacaaaaa atctcgtagc tataaaaaat 3201901 cttgccgttc ttacaaaaaa tctcgcagct acaaaaagtc ttactgttct cacaagaaaa 3201961 aatctcgcag ctataagaag tcatgccgca cacacaaaaa atcttatcgt tcccataaga 3202021 aatactacaa aaaaccgcac caccactgcg acgactacaa aagacacgat gattatgaca 3202081 gcaaaaaaga atactggaaa gacggcaatt gctgggtagt caaaaagaaa tacaaataat 3202141 ctaagttttc attgtttcaa taggctgccg gcggaggtac ggaagcctat ttttttattt 3202201 gccctgtatt agatatatgt catgacataa catatgcaac ccgcatcatt tggtttcctt 3202261 taaaccattt cgttataatc aaggtatcct aacgataaag gcggttgttg ctatgtacat 3202321 atttcaagct gatcagctta gtgccaaaga cacatacaag ctattgtcag gtaccgttat 3202381 tccccgcccc attgcatttg tgacaacact ttcttcagga ggagcggtaa atgccgcgcc 3202441 tttcagtttt tataacgtcg tcagctcaga tcctccgctt ctcagtattt ctgttaacag 3202501 gacggaagga cgccaaaaag atacagcacg aaacgcagtg gagaacggag aatttgtcgt 3202561 tcatgtcagt gatgaagcca tcattgaaga tatcaatgaa acagctgcaa gcttaaggcc 3202621 ggatgaaagc gagcttacac gcacctcgct tcatcctgtt gaaagcaaag ctgtttcagt 3202681 tcccggcatt aaggaagccc gcgttcgctt tgagtgcaaa ttagagcggc atattacctt 3202741 tgacaatgat caaggcatca ctacagcaga tctgctcatc ggaagagttg tctgcttcca 3202801 cctagatgaa aaggtgtatg atgcagaaaa gggatatatt ttaacggatg aattaaagcc 3202861 tgcctcacga ttggcgggaa atcactatgc caagctgggg gaagaattca cactgattcg 3202921 tcccagctga agagaaggac tatttaaata gaagaaacta gtcaaaaaga ccttatgatt 3202981 acaaaatatc gcctgtaaat aactgaaaaa atatcaaaaa aaagaacacc cagagcaagc 3203041 tcggggtgtt cttttatgaa acgtttttcc tttttcttcg tataaaggta gattaggagg 3203101 aattggaatg acaaactttt ggattttaat gctgatcgct attaccatca gtctcgcctc 3203161 tcaatttttt ataaagaaaa aatacggtat tgataaatcc ggctggcgat ataagcatgt 3203221 cagcaataca cacaaatgga tcgaaatcac tttacttatt ttgtttgtgt tttcactctc 3203281 cttttttcca gttgaatatt tgcttctttt attttttatt gtgattgact caatacgtat 3203341 ttttatggag tggcattata gacctgaaga taaacagtat atgtaccaca ttgtagaggt 3203401 ctcccttatg tttatgcttt tgatttatgt ttgtacccta tagttattta aatccccaca 3203461 gccgctccgt ctccccgagg atcggctccg ccttggagaa agccttcttc atcaactttg 3203521 attgcagccg cttgtcccat cagcggatca tagtcaccga caacctccac gagatgcccg 3203581 ctgtctttca gtttttggat tgttttgtct gtgaatctgc cctcgactct gagaccttcg 3203641 tattcctctc cccacgttct gccccatacc cagcgcggtt cgctgattgc ctgctgtgga 3203701 tgcattccgt agtccagcat tcgggtaatg atggccgtct gggtctgcgg ctggccttcg 3203761 ccgccttgtg tgccgtacag aatttttggc tttccgcctt tacagaccat agccggcatc 3203821 aacgtatgga aggtgcgctt tctcggttca agcgtgttga catgattttc atccagtgag 3203881 aaaaacgatc cgcggttttg cagtaatatg cctgtatcac cggcagtgac tgccgagcca 3203941 aattcaaagt acaggctttg aatgaatgac actgcgttgc catccgcatc gattacggcc 3204001 gcatatgccg tatcacttcc caccggcctg ctttctgccg gtattgcgag atagccgatt 3204061 tcttctgcca attgttttgc ataacgtttg tccaaaagcc tttcaagcgg aatgtctgca 3204121 aacgccggat cagtcaggac ggcatcccga tctagaaaac tctttttcaa tgcctccaca 3204181 agcacgtgat aatactcaaa tgaaccgtgt tcgatttggg tgaaatcata gttttccaaa 3204241 atgttcagtg ttaataaacc ggtaaatccc tgagaattcg gcggcgcctg atacacactg 3204301 tatcctcgat aatcacttga tacaggcgct gcccactcac cccgatgcgc tttaaaatca 3204361 tcgattgtca tgtaactgcc gttattctgt aaatgtgaga caatccgctg agcgagatct 3204421 ccttcataaa atgcgcttct tcctttttca gcaatcaagt tcagactgtc tgcaagctct 3204481 ttttgcacaa accgctctcc cgggacaggt gctttgcccc ttctcgtgaa gatgtcagcc 3204541 gtgtaaggcg tggaagccag cagttcaata ttcttttctg tgtgacgaca ctgatcagct 3204601 gatacaggaa acccattttg ggcataatcg cgtgcgggct ccaatacatc tgcaagagac 3204661 agacgcccgt actccttcag gaccgcatcc cagctatcaa ccattcccgg cacggtaata 3204721 gcactgtcaa ttccccgcag cggaatcgcg ctttttccct tatatacatc tctcgttacg 3204781 ttttttcctg aacggccgct gccattgtag acttttactg cctttgtttc ctggtgaaag 3204841 gtcagccaaa aggaatcccc gccaagtccg gtcatatgcg ggtacacaac cgcaagacaa 3204901 gcactcaccg caacagcggc gtcaaacgcg ttgcctccct tatccagtat gcggtttccg 3204961 gcttgagaag cgagataatg cggactgacg accatttgct ttgtaccgat gacagatttg 3205021 ttcatcacaa gtcccctttt ttaagaaatt ttcttcagta tagggagcct gatttttcac 3205081 atctactgat ccggcagaaa aactgacgaa ctttcttctt ttcgcaaata ataagatatt 3205141 ttcgcattca tttcgaaaac aaatgaaaaa ttattatttc tatacgtaac ttttatgata 3205201 aaatgattgc taaaaggcta cgaaagcagg tggagcaatt gagtcatgaa tatcaaatcc 3205261 ccaaccttgt acttgatgag actgataaac aaattctcac gattttgcat gaagaaggca 3205321 gaatttctta tacggatctt ggcaaaagag tcgatttgtc acgggtcgcc gttcaggccc 3205381 gtatcaacca attaattgaa gccggtgtta ttgaaaaatt caccgctgtc atcaatcccg 3205441 ctaaaatcgg catccatgtt tccgtgtttt tcaatgtcga ggtagaaccg caatttttag 3205501 aagaggtcgc tcttaagctt gaggaagagc ctgcggtcac cagcctttat cacatgacag 3205561 gcccgagcaa gctgcatatg catgggatct ttaccaacga tcaagaaatg gaagaattct 3205621 taacaaaacg gctgtatcca ttgcgaggcg tcgtcagtgt tgattgccag atgctgatca 3205681 aacgatacaa aagccgtatg ggaatgaagc tgtaaaggag agaaacaaat gaaaaaccat 3205741 ccttatcggg atatgacggc cgcaatggtt cgcaccggca tattagggtt cggcggcgga 3205801 ccttccgtga ttccgctgat ccgccatgaa gcggtcaata aatataaatg gattgacgat 3205861 gatgaattcg gagaaatatt agcaatcgct aatgcgcttc ccggaccgat tgccaccaaa 3205921 atggctgctt atctgggctt taagctaaaa ggcacattag gtgcaattgt ggcgatcctc 3205981 gcccacattc tgcctacatg tcttgcgatg gtgggcttgt ttgcggctgt aaatgtgtta 3206041 agccattcag caattgttgc aggtatgatt ggtgccgtca cgccggtaat tgcggtcatg 3206101 ctcggaatca tggcgtacga gtttggccaa aaagcgctta aaggtttcgg ctgggttacc 3206161 ggcatcctgt tttttatcat cgcttttatc ggcctgcaaa ctttacagat taatcccggc 3206221 ctggtcatta tcattttctt agcttacggg gcgtttcatt ttaaactgaa agacaaaatc 3206281 acaaataaac attcaaaaga taaaggaatg tcagcctcat gatatcgatc tatttattta 3206341 tggcgttttt tatcgcaaac ctactgggat atggcggcgg acctgcgtct atcccgctaa 3206401 tgtttgaaga agtcgtaaac agatacagct ggctctcaaa cgatcaattc tcaaatatgc 3206461 tcgcacttgc gaacgcattg ccgggcccga tcgccacgaa aatcgctgcg tatgtcggct 3206521 acagcgcagg cgggtggccc ggcttcctaa ttgccctgat cgcaaccgtc gtaccgtcgg 3206581 cgctcgcatt gatcgtcctg ctgcgcatca tccagcgctt ccgccaatca cctgtcatca 3206641 aaggcatgac gctgtccgtc cagcctgtca tcgcggtcat gatgctcatt cttacctggc 3206701 aaatcggcgc agacggcatc aaagcgatcg gctgggtcca atcgatcgtg attacgggaa 3206761 tttcgctcct tgccatgaca aaattcaaaa tgcatccggc atttttgatt attgcggcgt 3206821 ttttatatgg gggccttgtg atcccttatt tatagaaaaa agcacctgga caggtgcttt 3206881 tttattttag cccagaaatg ccgtttgata tgacagctgt ttcttctcct gcgtcactct 3206941 tgatcatgtg cttgacttgc agcgtggttc ctgccattct cacagattgc ttcaactggg 3207001 acgaattggt ttcaacttgt atccaaacag gaggctggac cttccaaaat aaatagagtg 3207061 caagaatcag caagccagca atgaccgaca gcaaaaactt catatcgcat cgcttctttt 3207121 cagtaagcgg ctcgcagcgg acagcgcctg atgatcacga agaatatcgc ctggacgatt 3207181 gccttctccc agcacatagc ctttaaagga cattcccata aaatgaaaaa tatgttcgaa 3207241 ttgctgaatc agcggcagcc cttttatttt tggattgtct ccgcccactg ctattacata 3207301 tgcctgtttc actgacattt gctgtttaaa atcaggaaat ctcggatctc tcaacgtctg 3207361 tgaccagcga tcaataaaca gctttaatgt ccctgacatg ccaaaccaat aaattggggt 3207421 ggcgaatata agaatatggc actgcaatat ccgttcaatg atagaatcgt agtcatcttg 3207481 aacaggacga aagccgcctt gggcgtgacg cagatcttca attggttgaa ttggatattt 3207541 ctgcaaataa atgtgctccg catcgaatcc ttgaacagcc ttctccgcaa gaacatccgt 3207601 atttccgcca gaccgagttc cgccgttaat aaccgcaatt ttcatgatgc atctgctcct 3207661 ttgtttacga atgattttct tcatcatata atggattcat caatcaatac agatgattat 3207721 ttcgattaat ccaatcgcta aaaccgattt agaaaggaag agaacaagtg gaattgaagc 3207781 agctgatcac ctttattacg gcggctgaac atgtaaactt caccctaacc gccaaaatgc 3207841 ttaattatgc acaatcaagc gttacctctc agatcaaatc acttgaagaa gaaatcggaa 3207901 cgcctttatt tgaacggctc ggcaagcggc ttatcttgac agaagcagga aaaacgttca 3207961 aatcttatgc acagaagatc attgcgttaa cagaagaagc gaaaatggcc acaaatcaag 3208021 taagagaaac aaccggaacc ttaaaaatcg gggcgacgga aagccagtgc acataccgcc 3208081 tgccccctat cataaaagaa tttaaacagg cttttcccca agtaaagctc atattcaaac 3208141 catatatctc caatgaacaa gcgaaagaac agctcttaca gggccagctt gatatcacct 3208201 tcatcttgga tgtaaaccgg atggaagacg cactgcacgt tgaatctttg attcaggatg 3208261 agatcaaaat ggtggctgct aatgaccatc cttttcctgc ggatttacca gtaacattga 3208321 aggatcttca aaacgaaact cttctgctga cagaggacgg ctgctcgtac cgcacgctct 3208381 ttgagaacaa tttgcatgac tccggtatct atcctaacaa attggaattc gtcagcatag 3208441 aagccatcaa acaatgcgtg atggccggac ttgggattgg aatcttgcct gaaatgacag 3208501 taaaagatga tattgcagca ggccggatga aagaactcaa ttggcagagc gattgccccg 3208561 ttttcactca attagcatgg cataaggaca agtggatgtc tgcgccatta aaggctttta 3208621 tcgatttgac acggaaaaca ttcaaataaa acctctccac aaggacgaca aggtttttga 3208681 gaccagggca cacacataca aaaaaaacac ttgatgactt agagccccaa gtgttacacg 3208741 tgatttttct gataaaacgt tcgcaaaaca tgcgtctcaa ggtcagccag gcggacaggg 3208801 atcggcagcc tgctttcttg attgatcaag ctcatcgtga tctgatagct gctgtctaaa 3208861 tcaatataat taccgcaaga caagaaaata ggcttcacgt cccgccgcgt tcgcagcgcc 3208921 cgtccatata cctcgccgtc aatgataata tcggtgtatg cgcctacttc aatttcaggc 3208981 gtcacgaaat cgcagccttt gattttgaga taggttttcg ctatcccaat cgtcggcttg 3209041 cccagaaaaa aagccgcatg ggtggcaacg cccatatgat tgtaatgcag atatccgttg 3209101 ccatcaaaca agaagacatc cggctccgtc tccagctttt tcgccgcctc gatgatcaag 3209161 ggcagctcgc gaaacgcaag aaaaccggaa acatacggca cgctgattct ccccatgctg 3209221 tgcacttttt caatgacttc ttttgtatca gcgtcaatta cgataataca gcacactccg 3209281 tatggttctc catcctgctc ccaataggcc aggtcgacgc ctgcgcaggt gttgatggag 3209341 tctggatgga tcgtggggga taggttgata cgatttttaa ggttaaattg cacttgtaaa 3209401 aagtcttgtt cctttttcat atcaaattta tgcacatcaa ataccttcat aacgattgct 3209461 cactctcgac ctaaattaat gtgagtctct cttctcgatt ctagtatttc aaaatgagga 3209521 ctatctgtat ctatctcgta cttatttaat agattgcctt cttcatccca attcttttca 3209581 gaaattagta tggaatgctc atactgttgc tcactttttt tcctgccatt ttcaaaccaa 3209641 attatgctta taccgtgcaa ttgcccatat cggtattctt tttcactttt tttattcccg 3209701 ttttcataaa attcacatgt taaaccatgg gccagaccat tcttatattt agtaaaatag 3209761 atgatttgac catttggata taattcgtaa gccagccctg taaacggctg gccattttcg 3209821 tcttcaggat tatctaaaat ctcatcactt accgaagaga accataaatc ctcaaagtcc 3209881 actccctttt cttttatact cttcatatca tattcatttt ccatacttta aagcctccgg 3209941 tatataattt gtattttgag ttatatattc acaatgtgga catctaggca ttgggacacc 3210001 ttctggcatc tttttattta ttttcctagc acttactaca tataccatta aatcttttaa 3210061 atccgcatca ggtctttgaa gtaacgcttc atttagagca ttaacttcgg catgagaacc 3210121 cgcccctgac gtctttatat aaccttcttt aagttctgta ggcatattta caattctatc 3210181 atgaataagt ggatgtagta ccttaggtgg cttcccatct atattgttta ttccaaaata 3210241 ataattgcct gtttttttgt ccaatacacc agctaccgca gggcctcttt gttttttagt 3210301 tagaccagaa gatttaattc tactaagttc gtttagtact tctgccctta gatttattcg 3210361 atggtgaaga tcttctttag acaatacacc atgcttattt cttaaatatt gaagcctagt 3210421 ttgtttttct tcagtagtct tagcaatatt gctaataagg ctttcattac tcactttatt 3210481 gacatatgga gcattttttt ggtacaaccg atcaaagtag tgtgccaatc ctgctccacc 3210541 aataatagta atagcttcca gcgccccttg cttccgcttc tcctcagaca ctttgtttcc 3210601 gaacatatcc cggcctgtga cagcttctga gaatccgttt gacgcaacaa ggccgtatgc 3210661 gcccatttct gtcattttga gaatgtctaa ggatttgcct gttttgtagg cgtctaatgc 3210721 gtgttcagca gcgatagctg cttttccggt tttgtagatg gcttttccgc ctttgaaggc 3210781 ccggcctgcc cagccgacga ctggtatgaa tccggcagcg gccatagctc ctgctgtcac 3210841 acgctccgcg gtggagagtt tttctccggt aaccggatca acgccttcgg ttgctctttt 3210901 ataatcataa tagccagtga cttctccagt aaagttgcaa actccatccc atgttttttc 3210961 gtaccacggt ttgtttgctt cttcctcggc tttttcctgg agccgtcttg cttctgcttg 3211021 ctgggttttt gcatcgatat aggttgttcc ttgattttct acttcaatga cgcttttgta 3211081 gacttcattg ctgtggaagg cttttttgtc atagtacata ggggatgcgc tcttcccatt 3211141 gctggtggcc tgcatgagaa cagaatattt ggtgagcact gcgttgtcca gagattctaa 3211201 attttgatat tcagtggtca gggattcatc aagcttatcg acagctgtga ttgtatcacg 3211261 tctgattttt tgggcatcgc ccatcttatc tgcatagtcg tcaagcgtgt acatgtcgag 3211321 atcaataata tcgctgatgc ctgacaaaat agaatcgatt tcttctttat gagcggagac 3211381 aatctctgag gctttcaggt ctccattggg cagctcatga tccaaaaaag aagtttccac 3211441 atatgaatca ttcagttctt gatctttaat atctcctgaa atgccgttta aaaacgcaat 3211501 ttgagcagag acaagcgtca gccagctgtc tacgatttct gcctgtccct gaaaaaaatc 3211561 tttaatattg tccgcgccat ttcctttaaa attatcgcct aaatcggcaa ctccctgaaa 3211621 cgcttttttc agcgtattca gctgctcttc aagcgtctca tattgctttt ttctgctctt 3211681 cgcttcttcg attaaagatt ttgattcaaa tactttactc atcgcactgc cctttctgtt 3211741 ctattttacc gctatcgcct cgtcctgctc tttgagtgaa tctacgttat cctttgtatc 3211801 ctcgatattt ttctgtaccg cttttttgta atctccgagc atggttttga tgttctcctc 3211861 acgctcatgg tattttttcg tataatcgag gctgtttttt ccgttggatc ctgcggcgcc 3211921 gattgatacg tcagcaagcg catctttgac agaatctaat gttttgatga ctgtgtcgta 3211981 cttcagctta atttctgaca taaaaaaaga tcaccaccat tttagtttac taattgtatt 3212041 tccgacttct tccgcgaact cttctccctt tttaagaaga tctgctgcac catttgctat 3212101 gaacaattcc gatgcatatt tagctttatc ccattcaaga tcaaaaattt tcccgttaat 3212161 cgaagccata tactcgttat atttatcatt cacaatctta gatgcttccg atttcgcctc 3212221 ttctcttccc ttgtcgaaat catcggcttt tgttcccgtc caatgcttgc ccaattccgg 3212281 tttcacaatt tctttgattt cagtgattgc ctcttcttgc agtgtgtcta tgtccttttt 3212341 tgcttttttc agcttttcga tcttgtcttc cacgtctgaa atttttccgt tgagcgaact 3212401 tttgatatcc gctagcatac tttcataacc catctgaatc acctcttaat actcaaaaag 3212461 tcgtatggag gggctgatga agatagactt ttccatactt tatttccata tattatattt 3212521 taaaatagcc agaaggcggc ttaaataggg taaatggctt aatttaggca tataacgctc 3212581 ttgaaatgta ggtatttgat cttgtttttg ttcgttatac agctaataaa agcgttttat 3212641 aaaatgaaat cacctaatgt catagttata aaggcacttg aaagaggcag atgttgttga 3212701 tctgcctctt tcggcgctga gcttattgtt catgtttatg ttcttcatct ggtcggccat 3212761 gtctgatttt gtcatttggc ttctattatt ccccccttct gaccctttgg atcaaaagct 3212821 tgtattagct gcagtcccag ttgtacagaa cgtttgaaaa gtcttttttc cttagatctt 3212881 caggtgtgat gaaaaaattg gcgatgccga cgtctcccca cattgaatcg atatcatcgt 3212941 ctgaatcaat ttgtaacagc atgatggtgt gttctttata tgcgtattcc cggggatcat 3213001 gctgggtaaa agaagcgtat ccgccaattt tatggccaaa tccgttttca gccagttcat 3213061 tataaatgtc ttcttcatcc tcgccgaact gaccaaagaa ctccattgtt tccatgcccg 3213121 tatactgctc aaattgaaaa tctgtaggca gcacccattc cgaagatttc acaggctcga 3213181 ctgccgcttc tgataaaatc ggaaaatcac attcgcctgt gccaataaat gaaaaatcag 3213241 aaacaagctc gtcatcgttt tctacgatat tttcaaaata gatcactctg aaattctttt 3213301 gttcacatcg atcgtcaaaa ttcaatccat agacgtcatc atgaacagaa atgtagaact 3213361 gcaggatacc tgaagaaggg tagccgtcaa gctggggaat gtgcgagaaa ttaatctgcg 3213421 ccagaagttt catcggctgt ccattttcgt cagtcggata tgtttcatgc ttggggaaat 3213481 agggatcacc ggcaattttg ctgtcatatc gtcctgtttt cccctttctc acattcagtt 3213541 tcacgtattc tttcgctgat ttctccagca agtcgcggta cggtctcatt ttttcgggca 3213601 gatgattcat cagattctct ccttttccgg catctccaag gttttatttt ctggttttct 3213661 tctaatgttt ttcaaacgaa tgtttaaaga agccctactt ctgcataatt ttccaaacaa 3213721 tagttaaata gtagcaaatg tattcagcac cccgcaatag atgaaaaaaa gactggtgcg 3213781 caaccagcct ttctttttca tctattgaat tgcacctgac ggaacaaccg ccttccgtcc 3213841 gacagaataa tactccactc ctgcagccaa agcctcatcc aatgtgtagc agtttctgcc 3213901 gtcaaatatg agcggcgttt ccatcaaatc ctgataagcc gctaacggga attgtttaat 3213961 gtcagcccag tcggttaaaa tcatgacggc gtcagaccct ttgacagctt cctcgatcgt 3214021 ctctttatat tcaacagctt gcgggagaac atgctttgca tggctaactg caatgggatc 3214081 gtaggctctg atacgggcgt cgagcgcagc gagacggtct gcaataacaa ttgacggcgc 3214141 ttctctcata tcgtcggtat tcggtttaaa tgacaggcct aaaagggcaa tcgtttttcc 3214201 cgtcacccca ccgagcctgt tcagcgcttt atcaaccagc atcgcctgct gattgttgtt 3214261 gactttgata acggatttca gcagttcaaa atcatgctcg acattgccgg caatttgcac 3214321 gagggcgttt gtgtcctttg gaaaacaaga gccgccgtag cctatgcccg cttttaaaaa 3214381 ctggctcccg atccgcttat cctgtcccat cccgtatgcg actgcttcaa tatcggcgcc 3214441 gaccttttca catatattcg aaatttcgtt tataaaactg atcttagtgg ccagaaaagc 3214501 atttgaggca tatttgatca tctcggcgct tctgatatcc gtttggtaaa tcgggatttg 3214561 aaacggacgg aagagctcct ccagcgtatt tgctgttttc tcatcggccg tcccgatcac 3214621 gatcctgtca ccatgaaagg tatcatagat cgccgacccc tcacgcaaaa attccggatt 3214681 ggatgcgacc gaaatactga caggctccgc tagatgttca gtaatcagtc cattaatcaa 3214741 atcgtttgtc ccaacgggca ctgtgctttt cgttaccacg actgtatctc gtttgacatg 3214801 ctttgcgatg cgtttggccg catctgtaat ttgctccaga ttggcgtgcc cgtcgctttt 3214861 ctgcggtgtg ccgaccgcta taaaaatgat gtctgcctgt gccaagcctt tctcatagct 3214921 cgtttcaaag ttcagccgtc catcagctgt attttttctc atcagctctt caagacctgg 3214981 ttcaaatatg ggggaaatgc cctttctcat ttcatcaatc ttgtgagcgt caatatcaat 3215041 gcaggttaca tgatgtccaa tctcagaaag agaaacacct gtcacaagac cgacatagcc 3215101 tgttccgatg actgttatat tcattgtttc cctccaacag ttaaattgct gctttgcagc 3215161 ttccgtaata tcgtatgaga acatcctatc atgaatgcga atgatctccc gcatagcctg 3215221 tcgggtacag cctgtacaga tttctgaaat gtgattcaac catacaatac actattatat 3215281 cgctctcaaa aagaaagtgg tgaaatgaga atcggctgtt aaaaaaaacc aaacaatttt 3215341 cttcttttga ccggctgcgg aggctgtctg aagatggtct gattccgcag gagaagctct 3215401 gcattttccg tcagcatata aggaagttcc gagccgaatt ctttctctag aacataaaga 3215461 gcctcttgag tgtgaaaatt tctcgttttc acattatggg catctgaggc tacgaaatgg 3215521 atcaaattgg cttcaaccag ccggagagaa aatgctttca gctgcttgcc gaagatcccc 3215581 gcaagacttc ctgaagtaat ctgagatgct gctccttttt ccacaagatg atacagcaag 3215641 gacgggtttt cgcgaatttc cctgttgcgt tcaggatggg cgataaccgg aatatatcct 3215701 ttcagctgca aatcataaaa aagctgctcc gcatatcggg gaacgtgatc aaacggaaac 3215761 tcaatcaaga tgtattttgt atcattcagc gaaagcagct gacgtttggc aaggtcttgt 3215821 tccacctcgc cgtagattct gatttcctgt cccggaagca catgtaaagg aatgtcttct 3215881 ttgattaaac gtttgtttaa ctgatctgct gcttctctga ctgcggctgg ctcgttttta 3215941 tacacaccgt tgttatgatg aggtgtcgca atgatcgtcc ggattccctg acgaacagct 3216001 gctcttgcca tttctatgct gtcggccgaa tcacctgccc cgtcatccat tgcgggaaga 3216061 atgtgacagt gaatatcgat catgtcctag cccccttttt tcgcaaaaat aaataacggg 3216121 cacgatgcac gttatttatt tttgcatgaa attgtccttg gttccgtaat atccgtattc 3216181 agagtgcttc gaaagctttt tgccgttcat aatcgcccca aggagcttgc ttttgcacgt 3216241 tgcaagcgcc tctttcgctt ttgcggcttg ttctttttct gttttcccgc ttgaaataac 3216301 cagaacagaa ccgtctgcca cgttgcctaa aatctgtgca tctgctacgg caagaatagg 3216361 cggcgtatca aaaatgacca tatcatatgc cgcacacgct tcgtatgcaa gctccttcat 3216421 ccacttcgag gagagaagct cggccgggtt tggcgggatc gggccgctcg tcagcacgtc 3216481 aagatgtttt tcattcgatg cttgtacagc ctgctccata gagcttttct ttaataaaac 3216541 agatgttaag ccaaccgtat tttcaagaaa aaaagccgta tgtactgttg gttttcgcaa 3216601 atcagcatca atcaggagca ctttttttcc ctgttgggcg aatacgacag ccaggttggc 3216661 ggccgttgtt gattttcctt cccccggaca agccgatgta atcatgactg atttcatttg 3216721 ccggtccact gaagcaaatt ctatattcgt gcgaatcgtc cgatattgtt cagagttcaa 3216781 ggatttcggc tctgtcattg caatgacatt tctctgcatc cgcgagcctc tgttttttct 3216841 aagcgccaaa atgtccactc cccgtttttt cagattggaa accctgtaag gtctttgctg 3216901 ttttctgctc attcgcaatg gtggaaactg tccctaaaac aggtatgtcc agcaaggatt 3216961 cgagctgctc ttccgatttg atcgtattat ccaaatgctc aagcaggaag gccagtccga 3217021 tgcttcccgc caatccggcc gcaaacgcga tggcaatgtt tagtagcggc tttggcgata 3217081 caggggacgg gtgttctgaa acctcggctt ttgacagaat gctgacattg tcaacattca 3217141 taatggatgt gattttgtct tgaaaaacag atgctatagt attggcaata tgagccgctg 3217201 tttccgcgtt ttcatccctg actgatatgt tgaccacttg ggagtcctgt tcgctggata 3217261 cggtaatttt gtcattcagt tcttgggatg tcatcgacag gcccatttct ttaatgactt 3217321 catctaagat ggcagggctc ttaatgatga cattgtacgt attgattaac tgaagattgg 3217381 tttggacatc gttaaattgg acttcttttc gttcattttt cgattggttg accagaatct 3217441 gagttgaatt ttcatagatg ggtgtaagtg cgaagaaact aatgagtccg ccggcagcag 3217501 tggcagccgc ggttacaatc ataatcaaaa gtatgcgttt tgttaacgtt gataatatct 3217561 cttttaagct tgtagattct cccatgatac ctccaaatct cttataacat ccttttccat 3217621 ctacgattat acaacgttga aaccgcattt ctccagcttt tcacgtgaca taattcgaca 3217681 tttttttaca atgcgttatg ttagtacttt ttatgtaagc gctatattta ctgtgttgac 3217741 agtgctgtct cattttctct tattcgggca gtcacgttct ctcgcataaa aaaatcccgc 3217801 taaaggcgtg cgggattttt atgttgcata tccattttta atatgagaaa tcaaattttc 3217861 aagcatttcc ttcgtcgtca tctcagatga ctgctcacca atttcatgtg catgcatcaa 3217921 aattttcaga aattcttctt gattcaattt cttttcactc atcttttttt tcctttcagc 3217981 ttccattaag ttgaaaacac gattattata tgatgctggt tatcaatttg caatctctaa 3218041 tacatcattc gacacatcct attttttatg tcctttttta ggaaaaactt tttaaggccg 3218101 atgtgttgcg atataataga gaaattggat ctttttatta cgtgactcgg ttaggagcga 3218161 taatcatgct tcagaatatg atttccaaag acgatgtgct ggcatctgct gaacagttaa 3218221 aagaacttct tccttacaat gaggaaaatg ttcagctgat caaaaaagcc cttattttat 3218281 atcggcagga ttcagtctat cgtttacaag cagtgagtcc gacggaagtt acggcttacg 3218341 tgcaggatgt tgtgcctgtg cgggtcacat tgaacttgtt tgtcatagtc aaaagcggct 3218401 gttcatgtcc gtccggaaga atctgccgcc atatgctggc tgtgttttta tatgtatatg 3218461 caatgttcga gcgagtgggt acttttacag agtattggct ggagagggaa aagcttgagg 3218521 aaagcaaaga gctcgtccgc cgccagtttc aggaaaaggt gctgcctaat gaagaatcac 3218581 tttcaagctg gcttgctttt tttgattcag agttttctct ctggcaggca cgtacgccag 3218641 aaggcagcca aaacatgcag ggcctctatt acggctacct gtccgcatta aaaaaacatg 3218701 cgccgaacaa gccggagctg aaaagcctgt atcagattca ttccgcgatt gcggtttggc 3218761 ttcgcatgtt cacattgatt gaagcgggca agctaaaccc cgaacaagat ttttattccc 3218821 tcaatccgta cgttgaacag ctgatggata caatctacag ctctattgat aaattaaaaa 3218881 cgtacgcgct gtcttttgcg cttgatccgt ttttggataa aacaccggat gttatccggc 3218941 atttgctgtt gaaagaagaa attttccaat atgaacgcat ccgcgtcttc ggtgaaattt 3219001 ggagtgcgct gctgtcgcgg ccaaaatggg tggcacgcga acaggagata ttgaaaaaag 3219061 aagcaggacg gcgtttttct cccgaattgc aattcgggcg cctgcatttg gaattcctgc 3219121 aaaaaaatga tgacgttatt tttgaggaag cggatcaatt cccgccggaa gcgctccctt 3219181 atacattcca atggctgagt gaaatgactg ccaagaagga ctggaaacgg cttaaaacat 3219241 ggtaccagca aattgaacca attgcgatgg gttatacgaa gctggataag ccgtttaaag 3219301 agattcgcga tgtgatcggc gagctgttcc ttctgttgaa tgcctatgtg cagcaaacca 3219361 atgatcaagc gctgtttgag cgctttgccg cgggctgtct gccgtatacg ttcacagaat 3219421 acagccatca tttatatgaa aaaaaacgct atgccgagtg gattgaaatt catagccttg 3219481 tcggcttttc catcaatgaa atggataaaa tgatgctcaa ggaaattgca gcgagcgacc 3219541 ctgaggcgct tataccggct taccatagag aagtggcttt tttcattgat cagaagaacc 3219601 gtagctcgta caaggaagcc gcccggtatt tgaaaaaatt gcgcaccctg tacaaaaaag 3219661 cgaaaaagca gaaggtgtgg gagcggtata ttcagctgct gagctcgcat tacaagcgcc 3219721 tgcgtgcgct tcaagaagaa ctgcagaaag gaaagttgat tgatggcgag tcttaaagaa 3219781 attctcatcc acgtcgaaca aatggaagat gggtcattta cgctctcagc ctttgatgag 3219841 aatgagcagc ctcttcccta cagccatatg aaaaagcatt tgttccaatg gcatgaatcc 3219901 tcattttacg gaacctttct agaggatgtc agcttcatcg ggacgactgc tgtccttcta 3219961 tctccatgga tgactgtaga gcttctcggc aaaaactcgt tcaactcatt cagctccgtg 3220021 cagcttacag aagaaacgga gccgctgatc gaggcggcat cgaccatcta tgaatttatc 3220081 gcggacggcg attttatgcc tgactatgac gcatggacaa acggtgtttt tcgctggaag 3220141 gaccgcgata atatactgga aggctttact gcggaatggt tttccgctgc cgtacaggat 3220201 tacatccagt acgacgatga cctgcgggag aaatgggaac atatcaagga aaaatcgcct 3220261 gcggttacga cattccgtgg ccattttctt gatgaagagg attttctgga aggcattggc 3220321 tggattgacg atcaatctcc atttactgtc ggcttgcgct taaatgaacc ggactttgac 3220381 ggagacgaat ggaagatcga gatgttttta cgcgataaaa agagcggtgc tgtagaattc 3220441 tttgacggac tgaagagcct caaaaaatcg tggcaggcgt acagcgataa aatcgcgcgt 3220501 gagcaggacc gctttcacag aacggttccg tggctgtcgt ttgattccgg gacaacgctg 3220561 atctcggagg aagaagcctg gatcttcctg tcagaagcaa gtgagacgct tgtcgatatg 3220621 ggggtagaaa tcctcctgcc gtcctggtgg cagattgtca gagacagcaa catgatgctg 3220681 aaagcaaagg tgtcttcctc cccgcgcggc gagtcatttg tcggcatgaa tgcactgctt 3220741 gatttcaact ggcggtttgc gacaaatgga attgaactga ctgaggctga atttaatgag 3220801 cttgtcgcca gcaacaggcg ccttgttaat atccgcgggc aatgggttaa aatcgatccg 3220861 cagtttatca aacagatgaa acgcctgatg gaaaaagcag aatcagaggg actccacatg 3220921 tctgatattc tggcgcggga gctaatggat cagcaggatg gcggacttga ggattcggac 3220981 ctgattgata catctgcttt tgccggcatt cagtttgatc tgtctaaaca gctcaggtca 3221041 ctgattcgaa agctcactgc cgcggaaaac ctgccggagc acaaagtcag tccttctttc 3221101 aaaggaacgc tccgccctta tcagaaatac ggcatgaact ggctgctgtt tctgcgggaa 3221161 agcggttttg gcgcctgtct ggctgacgat atggggcttg ggaaaacgat tcaaatgatc 3221221 gcctatttcc ttcacgtgaa ggaaagcggc cgacaaaaaa cgcctcattt gattattgcg 3221281 ccgacatccg tacttggcaa ctggcagcgg gagcttcaaa cctttgcccc tgatctgtct 3221341 gtcgcgctcc attatgggcc gcgccggcca aagggtgatg atttcgccgc gcattatgaa 3221401 aacgcagacg tggtgctcac ttcatacggt ctgtcacatg ccgatactga agagctttct 3221461 tctgtgacat ggaacacgat ctgccttgat gaagcgcaaa atattaaaaa cgcgcatacg 3221521 aagcaatcac gcgcaatcag gaagctgaag gggcttcacc atatcgcgct gagcggcacg 3221581 ccgatggaaa accgactgac tgagctgtgg tctatttttg acttcatgaa taaaggctac 3221641 ctcggcagtt tgaccggctt ccataaacgc tatgtgctgc cgatcgaaaa agaccgggac 3221701 gaaaagagaa tcggacagct tcagcaatta atccggccat tccttctccg ccggacgaaa 3221761 cgggatgaag aggtcgcgct taatcttcct gagaagctgg aagaaaaaga atttatccct 3221821 ctgtcagccg agcaggcatc cctttatgag cagctcgtca aagacacttt tgaccatatg 3221881 acatccctga ccggcatgca gcgaaaagcg ctgatcctca gcatgcttgg acggctcaag 3221941 caaatatgcg atcatcccgc gctttattta aaggaagagc aaaccgagct gctggccggc 3222001 agatcagtca agctcgaaaa attgctggaa ctgatgacag cgatccgcgc ccaaaacgaa 3222061 agctgcctga ttttcacgca atacattcag atggggaaca tgatgaagcg gctgcttgaa 3222121 aaaacgttcg gggaacctgt gcaattttta aatgggagtc tctccaagca agagcgggat 3222181 acactcgttg agaaatttca aaggaaagaa tatccgacac tgattctttc actcaaagct 3222241 ggaggcaccg gacttaattt gaccgccgcc aatcacgtca tccattatga cagatggtgg 3222301 aacccggcgg ttgaaaatca agcgactgac cgtgcatacc gcataggcca ggagcgcttt 3222361 gtccacgttc ataaaatgat tacgacagga acaatcgaag aaaaaattga tgtcatgctt 3222421 gaatccaagc aaaccctgaa cgatcaaatt atccaaagtg aaaactggat taccgagctt 3222481 tccacacagg agctcgaaga attgtttaca ttaagcgcta cagcgcaata atcatgacta 3222541 aaaaagctgg ctctaaaaga gccagctttt ttccgttcat agccgtcacg ccgaatttcc 3222601 aaaaaatccg ttacgccggt tatcaacagg gtgcgctttt gtggcagcac atatacttac 3222661 aacaaatgtt tcatcatatg tgcgacaccg tgttcgtcat tggttaaggt gacagcatcg 3222721 gctatcgatt tgatgtcttc ccgggcattg cccatcgcta caccttttcc cgcagcctcc 3222781 agcatcgatt tgtcatttaa actgtcacct acagcagcag tttcctcgag cggaatattc 3222841 agctgttttg caagcctctt cagcgcctgc cccttggaag ctttgcggga agaaagctca 3222901 aagttgtgct cagccgaact gacaagcgtc aaatcttcgg catgctcata tcttttccag 3222961 cctgcctcaa gcttttcttt gaagaaagaa aagccgagaa tattgtaaaa atcgattggc 3223021 tcatcggctt caaacagctc ttgaaaggag ttaatgtaag caaagcccga ttggctgtat 3223081 tgcacctcgg ccgcctgctt aaggacagaa agatccgctt ccggatttgc gcttctgaat 3223141 ctgtcgagct caacatcaag aagttctctg ccgttttgcg gcgtataaat cgctgaacct 3223201 gtgaatacct cataataata gttttccgac tcaagccatg agagaatgtc atacgcccgt 3223261 ttcttatcaa tcgtttcgtg atgataaagc ctgccctcgg gatcgtgaat gacggcgccg 3223321 tttgcactga tgacccatgt tttgatcccc agcggttcaa agattgacat gacgtcaaaa 3223381 tgagcgcgcc cagttgacac caccacttca atgccgtccc gctgcgcctg ccgcagtgcg 3223441 ttttcatttt ccaagcttac ctgatgcttg ctgttgagta aggttccatc taagtcaatc 3223501 gcaattaatt tcacgtttgt cagtcctttc cttcatcctg ctctgtcacg agaagctcaa 3223561 cgccgtttcg gtcaagcaag tcacaaaatg cctgattcgg cagcctgtct gtaatcaaga 3223621 ggtcgatttc attcagctcc gcatactgat aaaaactggt gctgcccagc ttagaatggt 3223681 ctgcaagcgc aattacctgc tttgcctgct gtatcatttt ccgcttcacc atgccatcct 3223741 cttcatgcgc aattgtaatg ccatgttcgg aaatgccgac cacaccaatc agcgctttat 3223801 caacatggta gcttgagagc ttttcaatca cagaggaccc gtacagaaag cggtgctcct 3223861 tttccagctt gcctcccagc agataaattt caattccctc tttatcggac agcacatccg 3223921 caagattaat cgaattggtg attacggtac aatcaaccgc attcaaatgc tttgcacatg 3223981 cctgaacagt tgtagaggcg tctaaaatca cccggtctcc atcatgaata agcgatgctg 3224041 caagcctgcc gatcttattt ttttcctcag acactgtttt caggcggccg gaatagcttt 3224101 gaattttctg atgcacagtc ggtaaaatgg cgccgcctct tgtgcggatg atggcattct 3224161 gttcctcaag tttcacaaga tctcgtcgcg ctgtatccct tgacacttgc aggagcgtac 3224221 agatctgctc cgttgtaatt cggttatgct gttttaaaaa atccaaaatc gctactaatc 3224281 tttcttcttg gtacacgccc tcattccttt tctcagcaat catttataag taattataag 3224341 tttttatttg attttattca acattaataa gtgattttaa gtaaaaatgc gtcgagagaa 3224401 ccaatttttc ctaagtaggc aaaaagaaag aaccagtctg gtcgactggt caattttgag 3224461 gggatgatgc gaagatccgg ataatagtga atggatagat aacgggagga gcaggggtgt 3224521 caatcagcag ctttttcccg gggtttaggg tccataaaac gaacagtgtc agccaacact 3224581 tctgttacat acacgttaac gccttcctcg ttttcatagc ttcttgtctg aatccgtccg 3224641 cttacgccga cgagagaacc tttttggcaa tacaacgccg tgttttcagc tgtttttctc 3224701 caaagtgtgc aattgacgta atcagcttcg atttcacctg aagcattctt gaagctgcgg 3224761 ttcaccgcga gcgtaacatg tgcaactgcc gcaccggcgg aagtgtagcg aagatcagga 3224821 tcttttgtaa gacgtccgac aagcatgacc tgattgaaca tgcgattcct cctctccttg 3224881 cggttgtatg tattgtaaat gatgcaacaa gaaaagaaaa acgcttaaaa atggctttca 3224941 gcctctgttt ttatctttcg ttttcatttt tccttcagct aaaaacatct tttgcttttt 3225001 tcctttgaag aaatatgtac tttttaaaaa acggaaaaag atttgctttg tcagccagtt 3225061 ttgcgtattc atgcgcacat aggaagagcc atcccacgca aaccactgaa agctcaattt 3225121 tttttccggc attgacagct tgattttata ctgctccatg ccatcttgtg tttcgtataa 3225181 aaaacttatt cttccttttt tgttcagatg aacctcaaac acttctttac ggcttaacat 3225241 atatgttact tccttttgaa tcaaatgact ttcagaagga acgccgtcaa tataaatttc 3225301 ttttaaacga aattgattca taccacatct ctccgtaatc catagtcagt tacagtataa 3225361 tgaaaaaata gaaattatta aatgtttcgc tcatacaaaa ttctttagcc ccaacattgc 3225421 aggatttttt cctcgaaaac gtttatgtta taatggaagg caagaaaact ttggaagtaa 3225481 tcggggtgag aagaaatgaa aacctttaaa ctggttgacc tgaatgtgga acgagtggac 3225541 aaggaagaac aatcaattga acagtttccc cttattgacg gactgattat aaataaagaa 3225601 gacggtgaaa atcactggct gattgaggcg cttgtacaga aagaacatct gtcttttttt 3225661 gaacagcttc aaaacagcca atctgaagcc aaagtatttg taacgatcac gaaaaaaagc 3225721 aatcgccccg cccagctgac agcagcagtg aaaaatatcg tcaagctgga agaaagcatt 3225781 caggttttac tctacggaca aatggtcaca agaaaacagc agggcactga aaccattctc 3225841 gagtcccttg taaaagaggg ctatacagga acaaaactca ttgaggcatt taagcaaaaa 3225901 ttataaatat gagggggcat gttccccaaa acagactcag aaccgaagag catcacaata 3225961 gacatttaga atagatatgt tctgcatgaa aaaagctgcc gttttgaacg gcagcttttc 3226021 tcttcgtgct ttcactcttg catatttaat ttgtatggcc aaaagaatca accaattccc 3226081 ctttcacaac gaggcgccct tcggttttga ccgccttgtc acatgtgatt aacgtaatct 3226141 cctttttgtt tgtctcctca actacatctg catccatttc cgatatgatg tctttcgatg 3226201 ttacagaata gatataatcc tttttaaaat ccgtgatgac aatttgggca cctgttttta 3226261 tgttttccag aggtccgaac agaagattct tttgcttcaa atgatggccc gccaacggat 3226321 aatttccctc acccattttt tgatcccggc gcattgttgc cgcccctatc aaaagatttt 3226381 cattggttgt gccttttacg atcggaagct ccagatcgac acttttaatt gttatccgcc 3226441 gccttgattg tgaagtaaaa ataagtatat ttcacgtgct ttcgacgttc tccacttgac 3226501 tggaatgctt taatggcgat cccggcatct gtagcttcag gctttccttc agaggaatca 3226561 gaaatctcaa actctatttt ctcagtgttc agcacataac cggctggcgc tttcgtttca 3226621 acaaaagcgt attgtcccgg tgcaaggcct gaagctgtga cttgatgatg ccggatatga 3226681 ctggtttcga agtctgtatg aaaattcgcg aacgattcag catggttgat cttccggttc 3226741 tgatcattac agctgccatt atcggccatg acaaatacaa ggcttttcat gccggagcga 3226801 atgacatttt gcaaaaaccc tatcattact ctgaatttat ggcgcgtatt caaaacctga 3226861 taatgatgaa acatacagca aatcaagcca caagaatgga aatggcgttt ctccagtcgc 3226921 aaatcaagcc tcattttctt tataatgtat taaacacgat tatttctctc actcatttgg 3226981 atattgaaaa ggcccgggag gtaacagagg aatttaccaa ctatttaaga atgagttttg 3227041 actttcaaaa tacatcagcc atcagttcct tcagacatga gctttcgatt atcaattcct 3227101 atctttctat agaaaagacg cgattcagta atcggcttga ggttcttttc gatatagatg 3227161 aagacattga ctttatcctt ccgcctttaa tgattcagcc cttggtggaa aatgccgttc 3227221 ttcacggtgt cagcaagaaa agaggcggag gatggatcaa actgacagct aaaaaacaaa 3227281 gcaaaaatga gtatcacatc aaagtagagg ataacggtcc cgggataact ccggaaaaac 3227341 aaatagatct cttatcaacg gattttgatc gcagcgtcgg attgaaaaat atcaatcagc 3227401 ggctgaaaca tttttgcgga agcgagttga tgatcagcag cactccggat gcaggcacct 3227461 ctgtctcaat gctcattcat ctcgctgaaa caacaggaag ccctaaagaa ctgaaggaca 3227521 cagaacgaac ctaaacgaaa attgagataa aaaaagacgc cgtttctaac ggcatctttt 3227581 ttattccggc gactttgctt gctgcttcag caggtctctg atttctttca gcagctcctc 3227641 ctgcgcatcc accgcttcct ccgcagcctc ttcttctgct tcttttttgc gccttaaccc 3227701 attcaaagtc cgaatgacga taaaaatgga gaacgatata attaagaagt tcacaatcgt 3227761 ctgtataaag ctgccatatt tcactacagc atcgccaaac gtaaacgaca ggcctgaaaa 3227821 gtcaagccct cccagcagca aaccgaccaa aggcataatg atatcattta ctagagatgt 3227881 gacgatcttt ccgaaagcgc cgcctatcac aacaccaatc gcaaggtcta cgatattccc 3227941 ccgcatggca aaggctttaa attcattcca catacaatca cctgcttttc tatatttgta 3228001 aagaaaaaaa gacaaatgtg ccgctggcca tctgcctttt ttcaattatt ctccgagggc 3228061 aaaagtcagt tctacttcgc aaacgacttc gccatcaact gtggcaacgc cttttccgcg 3228121 cccgattgtg ccgcgggcac gaatgatttc aacctcaagg tgaagctggt caccaggctt 3228181 gacttgtttt ttaaagcggc agttatcaat gcctgcaaaa aaagccagtc tgccgcggtt 3228241 ttcttcttta atcaacatcg caacagctcc gacttgagcg agtgcttcta cgattaatac 3228301 gccgggcata accgggtact gaggaaaatg tccgttaaag aactcttcat tagcggttac 3228361 atttttatag ccttttgccc gtttgccctc ttcaacttcc gtaatccgat ccacaagcaa 3228421 aaacggataa cggtgaggaa taatttcttt aatttgctga gtatcaagca ttgtcttgac 3228481 atctccttca tctgcattag tatgtatagc aatcatcaaa gatccaatct gtacatttga 3228541 aaagtatatt atgaattaat ctctttttca accgcgctaa aatgtaacca actgtcaatg 3228601 agagccgtca aaagttatga tatgataatt atagatttta ccaatagcaa agaggtagga 3228661 aaatgatttc gaagtttatt gaaaaaagaa tgctaaacat gttagacgag tggtattccg 3228721 caatgagcaa acgcaaaatg aatcacgttt gcacactgaa agagaaaatt gatcagcacc 3228781 ttccaaagat caaaaagaac acaaaacttt ggatgcgtta tcaattgttt caggcccgcc 3228841 atcagctgct ttttgaaaac cagaacggac tcgattcatt gttcgatggc ctatatggcc 3228901 tggaagacaa aatggatgat gaattgaaat attatctgta ttttttctct gggttatatg 3228961 agatggtaaa aacagctccg aaacatgcag tacatcattt taaaaaagct gaacagtacc 3229021 tggccgccat tcacaatacg tttgaagccg ctgatttata ttatcaaacc gccggcgcct 3229081 attacttgat gaaatcaccg ccgctttccg tccaatacgt caaaaaagca ttacacatct 3229141 atttgcacca attcggctat atcaaaaagg taatcacctg taaacttttg ctcgccgtga 3229201 attatattga tcaagaacgc tatgaaaaag ctgaacagct tttcaaagaa atcattaaga 3229261 aaacccagca actacatgac gaaaacctgc tatgccacgc ttattataac cttggctttt 3229321 taaaagcgac cgagaaaaaa gaccaggaag cgcttcttta ctttagaaaa gtattaaaga 3229381 atcaagaatt tgaaatgaat tcaccagtct catatcttca ttgtgtgtac gagtctgtca 3229441 gagcgctttt taaaacaggg aacatcacag aagctaaagc cgtccttcaa aaaggaaaag 3229501 aattatctga aaaggtagac attcaaacca tttatttaaa attaaaaacg cttgaagccc 3229561 tctacacatc agccgaagac ccttatgagc agctgctcga atatgtgctt gaattagaaa 3229621 aaatcgaggc gtgggtggat ttagaagtgc tgttagaaga tattacggaa tactacaaaa 3229681 aaaaggacga tttcgaaaaa gccgcttttt ttatcatgcg cggctgattg aaaaacgccc 3229741 attttcttat tatctgactg aattgattaa accgagcatt tgatctccca ttgtgatcgt 3229801 tctgctgttc agctgatatg aacgctggga cgtgatcaaa tctgtcattt gttctgaaat 3229861 atcgacattg gacatctcaa gtgagccctg ctgcatgccg atgttttgtc tattagcgcc 3229921 gttcagctct tcaaaagctg ccgcattatc aatagagaaa aggttattcc cttcggattt 3229981 cagctcttga gggttattca cttggacaac gccaagatta aaccgctgaa ccgcgtttcc 3230041 gtcagatgcg gttaaggtgc cgttcttatt aatggtgata ttcttcattg agctgtcgat 3230101 gttcactgta ttgccgttct catcaagtac gggataccca tttccagtga cgagctgcag 3230161 ctggttggca ttcgcagcgg acggcgttac atacagcgcc ccgtccctcg tatactggcg 3230221 gtttccattt acatttacct gaagatactg gtatggagac gtaaatgcga tatccagatc 3230281 gcgatcggtc ttctgaatgc ttccttgatc agagactagg cgtgaactca tcatcgctcc 3230341 gacgccaagg cgcaagccgg gcggcgtttt tcgggctttt gccacttcct cgtttttttc 3230401 atcaacctga tcgaattgct gtctgacaag ctcagaaaaa ttcgtatctt ttgccttata 3230461 gccggttgtg ttgctgtttg aaaggttgct gctgattgtg tcaatctgct gctgcagctg 3230521 gtttaaggtt gttgatgccg ttagcattga cctgagcata gttgatgtcc cccgtttttt 3230581 tcttccgttt tcttaaattt ttccaatttc atttgctgct ttatccatac ttttatcgta 3230641 agcctgaata accttctgat tcgcctcaaa cgatctgtac gcttcagtca tttctgtata 3230701 ggcgcttgtc acatccacgt ttgaaagctc tgagacgcct tgttttaatg aataggctac 3230761 ctgattattt ccggctgcgc ttggcagatc attaccgtcc gccgtgctgt acaaatcatt 3230821 tccgtcccgt ttgagattgc ggacatcttc cgccattctg acatcaatct ggccggctgt 3230881 gcgtccgttc gttgtcacag taccgttttc agacacagtg aaattctcat tatcaacagt 3230941 gattggctgg cgatccgtcg ataaaatagg gcgtccgttg atcgtcagct gattgttctc 3231001 atttagtgaa aatgtgctgc tttttgaata acggattcca tccgctgttt gaaccggata 3231061 aaaaagagca gctttttcat tggtttccgc actcatcgga acttgatttt cgatcaatgc 3231121 aatgtctgta ggctggtctg tggacttcag gcttccctgt gtaaagagag gcttgagctc 3231181 ctgcatatat actccggtat tcacggaacc gatttccgtc cttgatgtcc cggccggaga 3231241 ttttgattct attctgctga gcagcatctc agggaacgcg cgcatagagc cttgatcagc 3231301 tttatatcct gatgtatttg cgttagcaat attatttgaa agcatttccg ttcttcgctg 3231361 ctgggcaatc attgcggatg ttgctgtata taatcctttt aacaaatttc ccacctctaa 3231421 aaatggcatt ttttccagtt gtcatatagg aacgttcgtt ctataataaa aactcagtat 3231481 tttatcctat tatcgtcatt taacatcttt tcgtgaaggc tttttcataa aaaaacctca 3231541 ttctttttca gaatgaggtt tgtgaaatca gcttagtttg cgtttaggaa gcttgtccat 3231601 attatcaagc atgacacctg tgccgatggc tacgcaatcc ataggatttt cagcaacgag 3231661 gaccggtacc ttcagctctt cagcaagcag ctggtcaagg ccgtttaaga gcgcgcctcc 3231721 gccggtaata ataacgccgc ggtcaataat atcagcagaa agttcaggcg gtgttctttc 3231781 gagcacttgt tttgcagcct gaacaataac agcgacagat tcacgaaggg cttcttcaac 3231841 ttctttactg tttactgtaa ttgttcttgg aagaccggaa accatgtccc gtccgcgaat 3231901 ggaaatttcc tcgtgacgtg cgtctgggaa aacagttgcg actttaatct taatatcctc 3231961 cgcagtacgt tcgccgatca gcagcttgta ctcgcgtttg atataattta agatttccat 3232021 gtcaaacttg tccccagcca ttttaataga agaggaggtg acaatatcgc ccattgaaat 3232081 aaccgcgata tccgtcgtcc cgcctccgat gtctacaacc atgttaccgc ttggctggaa 3232141 tatttccata cccgcgccga tagcggcaac tttaggttct tcttcaaggt acacatgttt 3232201 cccgccgctt ttttctgcag cttctttaat tgctttttgc tcaacggatg taatattcgt 3232261 cgggcagcaa atgagcatgc gcggctttga gaacaggcct tttacattca gcttgttaat 3232321 aaaatgtttc agcattgctt ctgttacttc aaagtcagca ataactccgt ctttcagcgg 3232381 gcgaatcgca acaatattcc caggtgtacg tccaaccatt cgtcttgcct cttcgccaac 3232441 cgccagcact ttgccgctgt ttttatcaag tgcaacaacg gaaggttcat tcagaacaat 3232501 tcctttacct ttaacatgga tcagtacatt tgcagtaccg aggtcaatac caatatccct 3232561 tgcaaacatc tatttatatc ctccttgaaa atctgtttca cagtaaatat ccacattgtg 3232621 ccctaattat atatattatc ataaaatata gaaaaaaagt tggaagcaca ataagttctt 3232681 tacaaatttt tgcggatgtt ttatgaacga tttcaagaag gcaatgccag gtgattacga 3232741 ttgctgaaca ggctctcctt cgagaatttc atctttttta tatttgagct ttgtcgcttc 3232801 tcctcctctt aaatgcctga tggatttatg ataatcgagt atttctttca cttcgtttgc 3232861 caagtcgggg ttaatttcag gcagacgctc tgttaaatcc ttgtgtactg tacttttgga 3232921 aacaccaaat tccttcgcaa tgacacgaac ggttttcttt gtctccacga tgtacttccc 3232981 tatcttgatt gttcgctctt tgatgtaatc gtgcacacca ctcgacctcc ctaaaatgga 3233041 tgtgagaagt gtgaaatgag atccgtattc tgtaaagagt cgttcattat gccgcttctt 3233101 cgttgtatgg ttttaaaagt aagtttgtga aatatgccca cgatccctca cctcaaacac 3233161 tctctttgtt aggtttgtaa cagtgtatta gcattctttt gggaatatgc taaaaactca 3233221 ataaggacaa ggggtgaaac gaactttttc agattcagca aactatttcg cgtcactaaa 3233281 ttttcatctt tacaactatt gatcgctcct gtaaaatgaa ataagcaatt agttacttag 3233341 gtaagttttt tagaaggaga ccgacatgtc ctacgtcaac agacacctca ttcatcaaat 3233401 caaccaaagc gcccgcctga ttgccaagaa agccaatgaa cagctagagc cattcggcct 3233461 ttattcatct caatggtcag ttttatattg tttgcgtacg atcggaccaa tgactcaaaa 3233521 agagatttgg tcctatttaa atgtggaagc gccgactgtg actcggacga tcaaacgcct 3233581 ggaggagaac ggctgggttc agagacggca aggtgaagac aaacgggaaa aacttgttgt 3233641 cctcacaaaa gaagccgaga aaaaatacga agaaatcaat gtgaaaatgt tgaaattcga 3233701 ggaagagctg cttgcagatt tccgggatga agataaagaa gctttttctc atttattccg 3233761 catgttttta caacaatgaa aataaggaag tgacatacat ttgaaaaaag cggatgcgat 3233821 atggaccaag gattttatta tggtcctgct tgtcaattta tttgtgtttg tgttctttta 3233881 tacattttta actgtattgc cgatctatac actgcaagag cttggcggca cagaatcaca 3233941 aggcgggctt ttaatcagcc tgttccttct gtctgcgatc attacacggc ctttctccgg 3234001 agccatcgtt gagcgtttcg ggaagaaaag aatggcgatt gtatcaatgg cgctcttcgc 3234061 cctatcatct tttctgtata tgccgattca taacttttcc ctgctgctcg gattgcggtt 3234121 cttccaaggg atttggttca gcattttaac gactgttaca ggtgcaattg ccgctgatat 3234181 tattccagcc aaacggcgcg gtgaagggct tggatacttt gccatgtcta tgaacctcgc 3234241 tatggcgatc gggcctttcc ttggcctgaa tttgatgaga gtggtaagct ttcctgtatt 3234301 ctttacagcc tttgcgctgt ttatggttgc gggcttactt gtttcgttct tgataaaagt 3234361 gccgcaaagt aaggacagcg gcacgactgt attccgtttt gcgttctcgg atatgtttga 3234421 aaagggcgca ctcaaaattg cgacggtcgg tttgtttatt tctttctgtt attcaacagt 3234481 cacatcatat ctgtctgtat tcgccaaatc agttgacctt tcggatatca gcggatattt 3234541 ctttgtttgt tttgcggtga caatgatgat tgcacgcccg ttcacaggga aattgttcga 3234601 caaagtcgga ccgggcattg tcatttatcc atcaatcctg attttctctg tcggactctg 3234661 catgctgtcc ttcacacata gcggcttaat gcttctgctt tcaggggcgg ttatcggtct 3234721 tggctacgga tcaatcgttc cttgcatgca aacattggcg attcagaaat ctccggctca 3234781 ccgctccggt tttgcgacgg caacgttctt taccttcttt gacagcggaa ttgctgtagg 3234841 atcgtatgta ttcggattgt ttgtagcatc tgccggcttc tctgccattt atttaacagc 3234901 ggggctgttc gttttaattg ctctgcttct ctacacgtgg agccagaaaa aacctgcaga 3234961 ggctgaagga aaagtgtcta ttgcagaata acttgtcaga ctgccgggaa atcccggcag 3235021 tcttttttcc attaaaacac ggcgccctct cggttgaacg agagaacgcc gcttatagca 3235081 attattcaat gacaggccgc gcaggtgaat caggatctaa cgaaaaatca taggacgctt 3235141 catcacgaaa catcggatcg gcatatatgg attgttgatc gttttttgtt gcttttcgat 3235201 acgaagaaaa tgaatcatat tctttctttt tccacatcca tatgccgtct tgatccgctt 3235261 ccttgtggta cacgttatga ttgaccgtat taccttcgtt ttctgtaaag tcgtttccga 3235321 taaataatct ggaatcaccg gccgtcaata tattcttttc aattgtgttg tttttcgtat 3235381 cgtactgcag cagcagctgt ccgccgtaca gtccctttgt gtcattccgg tacataatat 3235441 tgcgggcaat cagagaattg ctggtgccgc cccgcttttt gtcatatcct ccgattgaaa 3235501 taccggtgta cgcattgttg tacactttgt tgtctgtgat ctgaatggca tttgcatact 3235561 ttcctttgtg ttcagacgtt gcttcaatcc caatatcgtt atcgtaaact gtgttgttct 3235621 taatttcgat atcgtgtcct ccatcgacat aaatcccgcc cgctgagtat tcatctccat 3235681 aagcaggatt gccgtaagtc gagttttgat aaactgtatt gttttctacg actccgtttc 3235741 gcacgtaatc gtttttatcc gcggttccct cataaccaat tagatcaatc ccgatgttat 3235801 tattgttgcg gaccacattg cctgcaactg tgaagccgtc gatattaccg ttcagcacaa 3235861 ctgcttcact cgctccaagc gtcagtttct caactgtatt gtcctcgatt cggatgtctt 3235921 tcatgctgcc agtcccataa actgcgattc cgtgagcatt tccttcatcc gctgttgtct 3235981 taatcccccg gatgtgatta tccttaatgg cgatatgact gctggaccct gatacataaa 3236041 tccctatagc agttgcttcc tcagatgaaa cagaaagatc ttgaattgtt aaaccgctga 3236101 tggcaatgtc atgtttatcg tgaatacgaa taagcggtgt ttcatattca gcgttcgcaa 3236161 cggattcacc gctaatcacg acgttttcat tttcatagtt tcggaatgtg ataggctttc 3236221 cgtccgtacc gctgtgcttt acatcaaggg tctcatgata cgtgccctcc cgaatcatga 3236281 cagttgtgcc ggcagcagcc ttctcagatg cgtgtgccaa tgtacgaaac ggcttttctt 3236341 ttgttccttc attttgatca ctgccatttg gcgaaacata cagataatcc ccagatcctt 3236401 cctcattcgc ttttgtctta tcataaacga aagcgaggat gacagacgtt aaaacacccg 3236461 ccaaaagaat aaaataccat tttctcattt tcgattccca tttcgtttta gaatagattt 3236521 ctaaaaccat tataaatgtt ctatttatgg aaaaccattt caaaaatatg aaaatatacc 3236581 gtctaaatag atcttattca gcctggcgga cctgcgcatg ttcaactgtt tcaattgcca 3236641 atgatgcagg cgggtgaaca cgcatcagaa caatgtagaa aagaaaggaa atcagcacac 3236701 ctacaaacca agaaatatcg tataagctct tcaatacagg aacatacatg ccaatcagcg 3236761 aaatcagcgc tcctaacatt gtggctgcaa acgcacggta attgtagccc ttccaataca 3236821 cataccgtcc tgtttcggaa tacaggtcat ctaccgagag ctcacgtttg cgaatgataa 3236881 aatagtcggc catcatcacg cctgccaccg gtccaagcat gccgcctatt aagccaagaa 3236941 acgcatacac gcttgtcgcg ctctccatca gcttccacgg aaccgtaaat aaagcgagca 3237001 acgctgtgat aaagctgcca cgtttgaaat tgatatattt cggcagggca ttcgctatat 3237061 cataagcggg tgatacgata ttcgccgcga catttacaga gatcgtggcg atgcagagtg 3237121 tgatcacgga caagacgatg acataagggt tatcaaaccg cgccaaaata tcgacaacat 3237181 cccaaatcgg ctctccgaac gcgacctgcg agccggaggt caccgtaata cttgcgaatg 3237241 cgaacagcgc aaacgttccc ggcaaaccgt aaaattgtcc tttgatttgc tctttttgtg 3237301 tttcagcaaa ccgtgtaaaa tcaggtatat ttaagatcaa tgtcgcccag atgccgatga 3237361 tgccagtaac tccggcagca aacggccaga atgtttctga aaacgtatga aactttcctg 3237421 gttgagagta tatcgggccc aatcctccag caatatcaac ggcccaccat accatgccgc 3237481 caaataccag atacactaaa ggccctgccc acacctcaaa acgtttaatc gactccatgc 3237541 cgtgatgcaa tacgagtaaa tgaatggccc aaaagaatac aaaggaaagc aaaccggaca 3237601 agtgaatgcc gagaatgttc cactcgccgc caatttctcc ccaacctggc cacatattca 3237661 aaagcaaaat gttcagtgcc gtgctacccg caaaggtctg gatgccaagc cacatgatag 3237721 ctgtaaacgc ccttagaagc gcggggatat tcgcgccgta tatcccgtaa gaagcccgaa 3237781 tgatcactgg aaacggcagc ccgtattttg tccccgcatg gccgtttaag gcaagagcgc 3237841 caaataggat aagtgatgcc gtaataatga tcgccagcac ctgccaaggc gaaaggccga 3237901 tcgcaattaa tcctcccacg gtcgcgtagg tcggtatgtt atgtatacat cccatccaaa 3237961 tggaggcaaa gttcattgct ttccacgtcc gtttttcctg tcccaaaggc accagatctt 3238021 cattgctcag cctgttggat tgctgctgac tctcttttaa tttcatagcc ggctcccctt 3238081 tccatattgt ctatatgtcg tcacacgtta tgttttttga cattagatgt cacttaatat 3238141 aactgaagag tcagacaata acactggcta tgatatacaa ttttcccgtt tgtatttgaa 3238201 cagcttaaac aagaaaaaga gacagacctc agagcccgtc tctttcttaa gatgcagttt 3238261 tcattaatgc agcaaatctc acagccatta acaggcttgc tccgcccgct ataatcataa 3238321 tgattcccat catatcaaaa tgggctgccg tgatttcttt accaaaaaga atgccaagga 3238381 tcaccgaaga caaaatcgat cctaggtaac ggcaggtttg aaacaggcct gaagtcgttc 3238441 ctaccatgtt ggaaggactc gtttccagca tcgctgcctg aagcgcgaca ttgcccagtc 3238501 cgtagcctat acccaagagc gacagaatga ggcctttacc gatggtctgg acattgataa 3238561 aaaagatggt taagagcacg gctccagccg tcatcaaaag cgctcccgca aagatcggct 3238621 tgacgacacc agatcggtcg atccatttgc cggttagagg tgacacaacg atgctcattc 3238681 cagacataaa cagcataaac aggccgctcg tttgaacaga aagatgcatt tcatcctgaa 3238741 agtaacttgg caaaccaaaa aataaacaat agaagaaaac attcaataaa ataaactgaa 3238801 catacacggc tgacaggttt cgctgtgttt taaacagacg gacatcaata aacggcttat 3238861 ccgttttcag ctcgcgccag acaaacgcac agagcagaag caagccaagc acaccttcaa 3238921 ccgcatgcgg cgacgtgctg aacgacagca aaaaggatag aaggaaaatg attcccccgg 3238981 caaataaaac aattccaaga atatcgagct gccgaataat ggttttgatt cctgcccctt 3239041 ttttctgatc tttcgggaac atatacaggc ccaataagaa gctgaggata ataaacggca 3239101 aattaacgat aaagatcgcc ggccagcctc cccatacaat caaaaacccg ccggctgtcg 3239161 gccccagcgc cgtcatggcg gacgcaaaaa tagagagtac agccaaggct gaagcttggc 3239221 gctcatgaat atgattccga atcaagccga cacctgacgg ataaatcgca ctgctcccca 3239281 ccgattgaaa cagccgcatg accaataatg tcataaacgt cggcgcaaac ggcgccccga 3239341 tggcagaaac cgcaacaaga ataagcccga ataaaaacaa gcgtttccgc ccaatcaaat 3239401 caccgagctt tcccgttacg ggctgcgcta cggcactcgc caagtaaaac gaggaaatca 3239461 gccaggaaac cgttgtaaac gagaggtgaa actcatgctg gatgctatgg agcgcaagag 3239521 agatcataga cgagttcagc ggattcagca ttgttcccga agccacagct gttaaaaaaa 3239581 cagctcggct ttttttcgat aacatcattt cacttgttcc agaaactctt ccgttgtccg 3239641 cgatttaccg attctcggga aaataaagcg cagtgtggct tcatgctctt catcgctaaa 3239701 tgtggacatg gcatctgtaa taaaaatctg ctgatagcca agctgaaatg cctcccgtgc 3239761 tgtgctttcc accccgatat tcgttgcgat gccgcacaat acaatcgtat caatgccgcg 3239821 acgtctcagc tgcaagtcta aatctgtgcc aaaaaaagca ccccattgcc gttttgtcac 3239881 agtataatcg ccatcctgca caccgatttc cggaacaaat tcggcccagt ccgccggcat 3239941 ttcccctgaa cctccctgcg caggctcatc cgtttgcggc ttcagggcgt ccgctccatc 3240001 atgaaaggct acatttacaa agctgatgaa cccgttatgt ttccgaaatt catctacgag 3240061 ctttttcgcg ttcgggacaa cctggccgct ttgatcaatc ggcacaattc ccttttgtaa 3240121 atcaatgata accaatgctg ttttttgaaa atcaatgttg agtgtattca tcatacgtct 3240181 cctcctgata ctgttagtgt ttctcacatt gcatatttta ctcttcacac tgcctaagtt 3240241 cttttatgat gcttgtgaaa ttctcagaag gagcgttttc tcatgatttt tcttttatgt 3240301 agtagtaaca ggttgtgcat acgaacaaac cggcaagcac tgtaatcata aagggcgtca 3240361 tcgcttcatc acctgcctgc tgtctatcgg ttcctgcctg aaaatgccca tgaatttgcg 3240421 gcggtccatc caaagcagga taagacacat aaccattaat atcgtgctaa gatcctgcac 3240481 gccaatatca aaacaatagt taatcaagac gatgttcaca ataatgggca taaaaataac 3240541 cgcccctaat gcagccgttc gcggaatcag taataaaaca gctgccagga tttcaccaaa 3240601 acctataaac agttcataga catgagaata accgaaaaat gtccacgcga tcgtaaaccc 3240661 cttcccggca gccgcctcga tttcaggcgt cacctcgcca aactggccaa ttaccacttt 3240721 cgccagaccg tacacgaaaa aattaaaggc taaaaacaat cggaacgtcg cgggaatcga 3240781 cttgcgtacc gctttcctca gcctgccgcc tttattcatc atacatcccc ctcagtgtat 3240841 tatttgatgt agtacactta atacagtata gagtattcta attaatgtca attccctttt 3240901 cagctcatat gaatagtttc ttttatagat acaaagtctt atatcgcaaa aaatgccatt 3240961 ctccttcctt tccatccctc gataacattt ctcaaaaacc atgtcaggaa atcttacatg 3241021 aaaatgtttt atcattcttt tttctctata atgaagaaat ataataattg ctttttattc 3241081 tgaaagatac ggaggaatga gacatgcaaa tgggcgatac agtttttatg ttcttttgcg 3241141 ctttactcgt gtggctgatg accccgggat tagcgttatt ttatggagga atggtaaaga 3241201 gcaaaaatgt gctgagcact gccatgcaca gtttctcttc cattgccatc gtttccatcg 3241261 tttgggtgct gttcggatat acacttgcct tcgcaccagg caattcaatc atcggcgggc 3241321 tggagtgggc aggcctcaaa ggggtcggat ttgatccggg agattacagc gataccatcc 3241381 cccactcgtt atttatgatg ttccaaatga cgttcgccgt tctgactaca gcgattattt 3241441 ccggggcttt cgcagagcgg atgcgattcg gcgcttttct tttattctcg gttttatggg 3241501 cctctttggt ttacacaccc gtagcgcact gggtatgggg cggcggctgg atcggccagc 3241561 ttggagcgct cgatttcgct ggcggcaatg ttgttcatat ttcctccggg gtggcaggac 3241621 ttgttcttgc cattgtgctc ggcaaacgga aagacggtac agcgtcttct ccgcataacc 3241681 tcatttacac cttcttagga ggagctttga tttggttcgg ctggttcggc tttaacgtcg 3241741 gcagcgcatt gaccttagat ggtgtggcca tgtacgcgtt catcaacaca aacaccgcgg 3241801 ctgcagccgg gatcgccggc tggatcttag tagaatggat cattaacaaa aaaccgacaa 3241861 tgctcggagc ggtatctggg gcaatcgccg ggcttgtcgc cattacgccg gctgccggat 3241921 ttgtcacacc gttcgcttcc attattatcg gcatcatcgg cggagctgtt tgtttctggg 3241981 gagtattctc gcttaaaaag aaattcggat acgacgacgc gcttgacgcc tttggcctgc 3242041 acgggatcgg cggcacatgg ggcggaatcg caacaggatt attcgcaaca acctctgtta 3242101 actcagcggg cgcagatggg ttattttacg gtgatgcaag cttaatctgg aaacaaatcg 3242161 tcgccatcgc cgccacttat gtttttgtat ttattgtcac tttcgttatt attaaaattg 3242221 taagcctctt ccttcccctt cgcgcaactg aagaagaaga gtcacttggg cttgacttaa 3242281 cgatgcacgg ggaaaaagca tatcaagatt ctatgtgagg agtgacgcta tgagcggtca 3242341 aatgttcaag gtagaaattg taacgcgtcc ggcaaatttt gaaaagctga agcaggaact 3242401 cggaaaaatc ggagtgacct ctctgacttt ctccaatgta cacggctgcg gccttcaaaa 3242461 agcacatacg gagctctatc gaggggtaaa aatagaaagc aatgtatacg agcgtttaaa 3242521 aatagaaatt gtggtcagca aggttcctgt tgatcaagtg acagagaccg ctaaaagggt 3242581 gctgaaaacg ggatcaccag gtgacggtaa aatatttgtc tatgaaatca gcaatacgat 3242641 caacatccgc acaggcgaag aaggacctga agcactttaa tatcggtacg agattcggac 3242701 actccggatc tctttttttg tgcacagaat ccccccagaa accgcgattc ctcttcgaat 3242761 tctcttcaag cgccgttatt tcagacaatc tctattttta tttgaaactt ttcatgagta 3242821 agattagtct actaaatata aaaatgtaaa aggtgattat ttgaactacg aaatttttaa 3242881 agcaatccat ggactatctc atcacaattc agttctcgat tccattatgg tcttcatcac 3242941 ggaatatgcc attgtcgcct atgcccttat cctattggca atctggctgt ttgggaacac 3243001 acaaagcaga aaacatgtgc tatacgcagg catcacagga attgcaggcc ttgtgatcaa 3243061 ctatttgatt acgcttgttt atttcgaacc gcgcccgttc gttgcgcata cagtgcatac 3243121 actgattccg catgctgcgg atgcttcatt tccaagtgac catacgacag gtgcattagc 3243181 gatttctatt gcgatgcttt tcagaaaccg caaaatcggc tggccgcttg tcatttttgg 3243241 gcttttgaca ggcttttcga gaatttgggt gggacatcac tatccggtag atgtattggg 3243301 cagcctcgtt gtcgccatca ttatcgggtt ccttttcttt agattttcag atctgcttcg 3243361 cccgttcgtc gatttggtcg tgaggatcta cgaagccatt atcaataaac tgacgaaaaa 3243421 accaaccgat caaaatttct aagaaagaca aaagccggcg tctgaaatca agacagccgg 3243481 ctttaatatt tctcatacat ctcttgtttt cttcgcttcg ccaacacata taaaccataa 3243541 aacaacccaa ttccaacagc atcgatgagc acatcccgga tacaaccatt cctgctgaag 3243601 aagagctgaa gaacttctgt gaaaaaagca aacgcaaatg agccggctgc agctgatctt 3243661 atgctgcccc gctgtttcca cagcaaatat gtcagcacaa agaaggaaaa cgcgtgtccg 3243721 attttttgaa taaacgcttc aggtacagta agctcagtaa aatccataac taaaaattga 3243781 gacagatcag ggtgcggctg aaaatgaaaa gccaccgttt gcgatacgac catgccgctg 3243841 aagctttccg tacagacaga aagcaggata aaaaagatcc agcctgcgag caataggcgg 3243901 ttcatgacat aacctccttt ataacgtacg tgcctacatg taactacata gacggtaaaa 3243961 caaagcaaaa agtaacagaa aaaaacgccc atcacaagga tagacgtttt cttcattaag 3244021 actgttcagt gtcttctgtt gtgctgcttt ctttagaacc agatttgtca gttgaatcat 3244081 cctttttctc accggatttt tcttctgttc ctttttcagt tgatccgtcc tttttctcgg 3244141 aagattgctg aatggattct tctgtttctt gggtggcagc tttttcaata gaagaaactg 3244201 gtttgtccat aaagtttaac ggattcattg caaccccatc tttacggatt tcaaagtgca 3244261 cgtggtttcc gctgtcttca ctgtaaaggt tcttgccaga ttttccgatc acttgatttt 3244321 gttttacttt gtcaccttgc tctacgctta cttcggaaag agattgatac acagtcgata 3244381 aaccgtcggc atgttctact tccacaacat atcccagcac tggatctttt tcagctttaa 3244441 caaccgtacc gctcagagaa gcagagacat cgaaatcttt tccgtctttc tcagctaagt 3244501 caattccttt gcttaggctg tacgtgttat tataggtaac gagtgctgct tctttctctt 3244561 cttttgcggc atcggtttca tagaactttt tcacaacaga aacgttttca gaatcaacaa 3244621 ccggcattgc gacattttcc attgactttc ctacttcaac tgcatcgtcg ttgttgtcat 3244681 atgcggagtt tccgccgtta tcagccaact gatcctttac ctcatcattt gatactgatt 3244741 gataccaaag gacagctgtt aaaatgacgg ccgcactgac taagtaaatt gcagggaaca 3244801 cccagcgttt acgaaaaaac tgctgaagtt ttttgacttg agaagttttc ttttcttcct 3244861 ctctcattgt ttcatcacct cagcaacatt ctgaacactt ttctgaaaat atatacaacc 3244921 tatccaaaaa aactttttta gatgtagttt gcacagactg aacgaaaata tgtatttttt 3244981 tgagaggagt gccaaaaacg tatgaacatg acattgcgtc ttgctgaaca tagagacttg 3245041 gaggctgttg tggcgattta taattcaacg attgcttctc gaatggtaac agccgatacc 3245101 gaaccggtaa ctcctgaaga ccggatggaa tggttttcgg gacatacaga gtcacgtccg 3245161 ctctatgtgg ccgaggatga aaacggaaac gtcgctgcct ggatcagctt tgaaacattt 3245221 tatggaaggc cagcctataa taaaacagcg gaagtcagca tatacattga cgaagcatgc 3245281 cgcggcaaag gtgttggatc atatttgctt caagaagcgc tccgcattgc cccgaatctt 3245341 ggcatccgct cacttatggc cttcattttc gggcataata aaccaagcct gaagctgttt 3245401 gaaaagcacg ggtttgcaga atggggacta ttccccggca tcgccgaaat ggacgggaaa 3245461 agatacgatt taaaaatttt agggagagag ctttcatgat tagtctggat aaagatgaaa 3245521 acgaaattga acatcataat gaagaaaata gccttgttga acaggagact gcacctgttg 3245581 gacaggagag ccgccagctg agcgcctccg ctgtcaagtc gctatccgac attgccaagt 3245641 ggggcaaaat ttctggcatc ttgttaatca ttatgggatc gcttgtcact ctgtctgttt 3245701 tgatgacagt gattggcgcc atcccgggcg tactgctcat tatttcaggc gtatttttga 3245761 tgcgctcagc aaaagcagcc gcggaagccg aaggaaatct aaccggcagc gctggcgaaa 3245821 gcatgcttga aaattacggg acatttataa aaatgcagct gttttatgca gcatccagta 3245881 tcgttactgt cctgatcggg atcattgtag ccattttcgt gctggtggta atcggcattg 3245941 ctgcttttga gaacacgcct tcgtatgatg atccggattc ttattattat gaggatgatc 3246001 cggtgtttga ataatgatga gacaggacag ggcatgagtt ccatataaac ggaaccatgc 3246061 ctattttatt tgactattca aagcaggccg gcgtaaacac caaatcctga agcaagcata 3246121 caatagacat ctctagtaga ggaaatcaac aaagcaacgc tgttacccag aaatgaatat 3246181 caaaaaaacg gatgaagtcg gaatcaatcc gaaaccgcac tttttatttc gggtgtctgc 3246241 atgcaaaaaa acacacccgg atcgtctgga aaatctcaac aatccgggtg cagatcttct 3246301 ttaatacatt tttttgcgtc tgtcttcctc agtcaaaaat tcaacaaaac tccgcatcgc 3246361 aaaaggctct tcctttattt gtcgtgcgta ggagcttttc cgctcttctg aaaggatttc 3246421 gctctttttg atcctgttca gcatatagat gtgaaccgtt ttttggattt gtttatgctg 3246481 atagcctgcc tctttaaaaa atgcgagccc gagcgccgcc aaaagggcga atatgcctgc 3246541 gctgatcagg gactccctgt cagctgaagc atgaaataga aaagcagcta aattaaagag 3246601 agagaatgca gcaagcggaa tagcaagaaa acggtaaatg acggtttttt tcatgaaagg 3246661 ctgtacggcc ttttgaattt tttgcatttc tgttttgatg aaccccggca tttgttcgac 3246721 tctgtaaaag ttcatataat cctccccctt tatttgatgt ttcaagcttc acgaacgtta 3246781 tcatatgtgt ttattttaac gcaggtgcaa gctggtttta aagaaatctg cccgtatttt 3246841 tcacgaagaa tctggatcgc cgctctttat tcttttaaaa tgtgagtgtt ataatttgta 3246901 atgggaatca gatcactgtt attcatggaa tactaatggc aatcttcttg ataaatatga 3246961 atgagcgggg ttacaaagtg agtatttctt ccatcctttt atcacttttt ttcattttaa 3247021 atattctttt ggccatcatt gtcatcttca aagaacggcg cgatgccagt gcatcttggg 3247081 cgtggctgct tgttcttttc tttattcccg ttttaggctt tattttatac ttattattcg 3247141 gccataatct cagacgcaag catttgtttc aatgggaaga ccggaaaaag attggaattg 3247201 aaaggctgct gaagcatcag cttgaagatt tagaaaccaa gcaatttcag tttaacaacc 3247261 gggcaacctt tgataacaaa gatttaattt atatgctgat tatgaataac catgctgtgt 3247321 ttacagagga taattcagtt gacgtcatta cagatggacg ggataaattt cagcggctgc 3247381 tgagtgacat ttcaaaggct aaggatcata tccatttaca gtattatatt tataaaggcg 3247441 atgaattagg caaaaaattg cgggacgctc tcatccaaaa ggcgaaagaa ggtgttcagg 3247501 tcagagtgct ttatgatgaa ctcgggtcca gaacgctgag aaaaaagttt tttaaagagc 3247561 ttcgcgaggc tggcgggcat gtggaggtct ttttcccgtc aaagctcagg ccgattaacc 3247621 tgcggctgaa ttaccggaac catcgaaagc ttgtgatcat agacggtatg accggttatg 3247681 tcggaggctt taacgtcgga gatgagtatc tagggcttaa tccgaaattc ggttattggc 3247741 gggatacgca tatccggctg caaggaacgg ccgtgcacgc catccaaaca cgattcatcc 3247801 ttgactggaa ccaagcttct catcaccata cgctgacata tattccaaat cactttcctg 3247861 attacggccc aaaaggcaac gtcgggatgc agattgtcac aagcggccct gattcggaat 3247921 gggaacaaat taaaaatggc tacatcaaaa tgatttcgaa cgccaagcgt tccattttga 3247981 tacaaacacc ttattttatc ccagatgcaa gcctgctgga tgctttaagg atcgcttgcc 3248041 tttcgggcat tgacgttaac attatgattc cgaacaagcc cgatcacgcc tttgtatact 3248101 gggcgacact ttcgtatatc ggcgatctgc tgaaagccgg agccactgtc tatatttacg 3248161 ataacggctt tattcacgcg aaaaccatcg tggtggatga cgaaatcgct tcagtcggca 3248221 cagcgaacat tgatgtccga agcttcaggc tgaattttga ggttaatgca tttatttacg 3248281 atatcaccat tgctaaaaaa ctggtttcaa cttttaaaga agatttgcta gtatccagaa 3248341 aattcaccta tgaggagtat ctgcagcgcc cgttgtggat tcgaataaaa gaatccgtct 3248401 cgcggctgtt gtcgccgatc ttataagatg cgtaaacccc cggcctttac ggccgggggt 3248461 tttcctgatg gtcacagtaa atgatgattg cctcccgcaa aaaagcggca agaccttctc 3248521 catattgatt gattgaatcg gtaaatcgct cgtcagtgat atacacttcc ccgagtcctc 3248581 tgaaaatgtc gagtgtgcaa tcgtaatgat attggcaaat atgatcgcga aatgccccca 3248641 cagcggcctg aatctctgca tcatcgggcc catgcttcat tcgcgccgca attcgtctgt 3248701 aaatcgaatc aaattcagcc atgatcgtgc gccaatcatc tgccgagtat gcagatgtcc 3248761 ttttctctgt ttcttctgcg atttcctttc catacagctt tctgacttca tcagcgtatg 3248821 tctgctggtg ctcttcaatg tctttcatgc ttaatccggc aaataaatcc ctcttattca 3248881 tcgtttcccc tccatcaacg gacaaaagcg tcctgtcaat tgtttgaatc atctcatcca 3248941 ttctttgttt tttcttcatc aatatctcct tttgcgactg aagtgccgct ttccggtcaa 3249001 aattcggatg atccagcatc tctttaatct catccagacg aaacccgatt tccttgaaaa 3249061 ataaaatctg ttgcagtctt tccaggtctg cgtcactgta caaacgatac ccagcatcag 3249121 taagcgctga aggattcaga agctcaatat tgtcatagtg atgaagcgtc cgaatgctaa 3249181 cgcctgatat ctccgccact tgtttaactt gatatttcat acataacacc tcctcttttt 3249241 tatcgtaaac aatcacgcaa cgttagggtc aatccccaaa atgttatttt ctatatacaa 3249301 aacttctcac aaatagtgta taaaagaaaa gtgagtattt ttttgtaaag gggagccagt 3249361 atacatgaat cctgaaacaa tgaacaaaac cctcatcagc atttcgaaat ggggaaaagc 3249421 tacaggcatt ttatttatta ttatgggcgc aattaccgcg ctttcaggcg cgttcttttt 3249481 tctaatcggt gccgtgccag gcgtactgca aattatttcc ggtatctttt tgatgaggtc 3249541 agctagggaa gcaggccaaa tggctgaaca caatagcgga cagtctgaag acttaatgct 3249601 ggagaattac gcgaaattcg taaagatgca agggatttat ttgatcgtaa gcattgctgt 3249661 atccattctt gcgattatcg ccttcttcat ctttttaatg cttgggattg ctgacggcct 3249721 tttcagcgat acgtacagca cttattaatg agaaaaaccc ggagctggct ccgggttttt 3249781 tattattccg cttcgcttac cactgtgaag cgttcatttt tgtgttcggg atgttcaagc 3249841 tcgtccaaca cggcaatggc ataatctgca tagctgatat agctgtctcc ttttgcattt 3249901 acgatgacat tgtcttttcc tttttggtaa gagccagtcc gttttcctgc tggatcaaaa 3249961 aatgccgcag gactgaggaa cgtccaggaa atggagtctg tctgctgcaa atctttcagg 3250021 ttctcgcctt gatttgatgc agttggcaaa tattctttcg gaaattccgg cgtatccatt 3250081 aaacgggttg ttttggcttc atcaacaaac aggcttcccg ctccgccaac aacaagcaat 3250141 cttgtgtgct tcgcgtcctt taaaatgctg atgagtgctc ttcctgcttc aacatgaaga 3250201 tgttcttggc cgggtgctgc tccaaaagcg tttacgaccg cgtcgaaagg cttgatgtct 3250261 tccgcagtca gttcaaacac atctttttcc aaaatcgcta cgtcttgctc ctgcactttt 3250321 gaagcgtttc tgacgatggc tgtcacttca tggcctcttt ttttcgcttc tttcaaaatc 3250381 tcgtttcccg ctttcccgct tgcgcctata ataccaattt tcatttttca tttcctcctt 3250441 atttgtaaca attttagtta catgttagcg gtgagaagtc atcccttttg attaaaagag 3250501 atgattcata acatctttta atgacttgct tgccagttca ttttccatcg ctctttgcac 3250561 actttcaaac gtttcatcca gagcgttctg aatttttttc cctaccggac atttcggatt 3250621 cgggttttca tgaaccgcaa agagttcttc ttgcttttgg acagcccggt acacttctaa 3250681 aagagaaata tcagcaggat cttttttgag gcttgcaccc ggcaccccgg cgcgtgatgt 3250741 gagaatatca gcttttttca gcaggctgat cattcttcgc acaactaccg gattcgtgtt 3250801 gacactgtct gcaatgattt ctgaagatgt tttttcatcc atcgagatga gggataaaat 3250861 atgaatggca acagcaagac ggctgttaat catgtttttt caccaccgtt gtaactataa 3250921 tagttacatt tgattcgttt gtcaacatct aatatacact aaatacatgg gttttgtgca 3250981 ccgtttttag tcaatagaac ggccggatgc actccggccg cgtcttatca aaataagaaa 3251041 tatctttgtc caagtgggac ataatcgaca ggctggcaag acaattcctc cccgtcagca 3251101 aagacctgat aggtttttgg atcaatctca atcttcggca aagccgaatt cagcttcata 3251161 tccagcttgc tcagctttct gatatttttg actggagaaa tccttttttc cagccctaag 3251221 ctttccgcca caccacgctc tatgcttgcc tgagacataa atgtaatcga ggttgagcgg 3251281 ttggcttttc cgtaagacgc atacatttgg cgcatgaaaa ccggttcagg agtcgggatg 3251341 gacgcgttcg gatctcccat ttgcgcacgt gcaatcatgc cgccctttaa gaccagttcc 3251401 ggtttcacgc cgaaaaatac cgggtcccac agaacgagat cagcaagctt ccctttttcc 3251461 accgagccga cctcatggct gagcccgtgc gtaattgccg gattaatcgt gtatttggca 3251521 atgtaccgtt ttgcgcgcac attgtcattc ccgttttcac cggcaagagc gccgcgctgt 3251581 tttttcattt tatcggctac ctgccatgtt cggatgatca cttcaccgac ccgccccatc 3251641 gcttgggaat ccgatgatgt catgctgatc gcacctatat catggagaat atcctccgcg 3251701 gcaatcgtcg ccgccctgat tctggaatgg ctgaatgcca catcttcagg cactttcgca 3251761 tctaaatggt ggcagaccat catcatgtca agatgctcat ccatcgtatt aacggtataa 3251821 ggaatggttg gcgttgtaga tgacggcaga atgttcgcgt aagaggcgag cttcataata 3251881 tccggagcgt gaccgccgcc tgccccttca atgtgataag tatgaataac ccggtccccg 3251941 atcgcgtcga gcgtgttttc caaaaagccc gcttcgttaa tcgtatcggt atggatggca 3252001 acttgaatat cagcctcgtc cacgacttcc atacacgttt taatggcgct tggcgtcgtt 3252061 ccccagtctt catggagctt aagaccgatg gcgcctgctt ccacctgctc gatcagcggc 3252121 gctttatcgg atgcattccc ttttcctaag aagccgacat tgatcggaaa ctcctcggcc 3252181 gcttccagca tcctcgccat ataccacgcc ccggacgtac atgttgtcgc tttgcttcct 3252241 gtagcgggtc ctgttccgcc tcccaaaagg gtcgtcacac ctgaagaaag cgcaacttcc 3252301 atctgctgag gacaaataaa atgaatgtgc gtgtccactc ccccggctgt taaaattttg 3252361 ccttcaccgg aaatcacctc tgtccccgct ccgatgacca tgtgcggatc gactccatcc 3252421 atgatatcag gatttccgct ttttccgaca ccgacaatcc ggccgtcttt cacaccgaca 3252481 tccgctttga caatgcctgt gtaatccaat agcacgacgt tggtgataac caaatccaaa 3252541 gcgccgtcct tccctgtgat tctgccgttt tggcccatgc cgtctcggat agtttttccg 3252601 ccgccaaaga tcatttcttc accgtatact gtgaaatcct tttcgacttc gatccataaa 3252661 tccgtgtcgc ccaatctgat tttatcgccc gttgtcgggc caaacagttc cgcatattcc 3252721 tcccgtgaca ttttcatcgg attacaccct ccatccagcc ggcttgtttt aagttggcca 3252781 acgttttttc tttgccgcgt tcatcgataa acgtgtcggc cattccgttc agccctctaa 3252841 ttgtcttgcg tcctctgatt tccactagtg agaccgtttt ctgctctccc ggctcaaaac 3252901 ggaccgacgt gcctgatgga acatcaagac gcatgccgat cgccagctca cggtcaaata 3252961 ataaagcccc gttggcctcc gcaaaatgaa aatgcgaacc gacttgaatg gagcgtgatc 3253021 cggtgttttt taccgttacc tcccgtatct cacggccttc attaatcgta atggttccct 3253081 cagcaatttg aaatgctccc ggcttcatga cttcacctcc gcagaaattg gctgatgtac 3253141 cgtaacaagc tttacaccat ccggaaatgt ggcctccacc tgaatgctgt ccagcatctc 3253201 aggcacaccc tccatcacat ctttttccgt taatacatgg cggccggctt ccatcagctc 3253261 tgctactccc ttcccatcac gtgcgccttc cataataaag caggtgatat aagcagcagc 3253321 ctcaggatag ttcagcagaa cgccccgcgc ctttcgctgt ttggctaatt cccccgctgc 3253381 aaaaatgagc aatttctctt gttcaactgg tgtcagtttc atctgtagtc ctccttcttt 3253441 tgtcatataa agcagatgcg gctactacga atttgcggaa cagtcaggcg ggacatcacc 3253501 tccctttctt cgagaatggg ggtcatacgg taagatgcct ttcaaagcgg catgccgttt 3253561 cttcatcagc cttgccatgg tcaacaaccg ttcccctgtc gatcacggaa agatcagatt 3253621 aacgcgtttt ccagactgcg ctcgactaag ataacaaatg tctttttttc tggaaatttc 3253681 tataataact tgtctgacta gttcgacaat taaaatctga attccttcca attgtttatt 3253741 aagtaaaata tttttcagat ttaccatcag cgctctggtg attgcaagct gctgctgttg 3253801 accgcctttt cgttttgaac aaacgtttga ttaaaacaaa tagccccctc tgtttagccg 3253861 gagtcggcct aatacagcga caatctgccc cgggcgaagc taaggctgtg caaaaccatc 3253921 gattgatcat aaccagacgt tacattcctg atggcagccc gttgttttgc tccgcaaccg 3253981 gaagcatggc atggaggcca gtctgaggcg ccgacctcca cgataccgag aacccgacta 3254041 ttgccattaa ctccgcatca tggacggtca cttcgctgat cgccaccgtt cctcttaatg 3254101 agtgaagaat tccggccttc actgaatccc cgcttgtgtc gatatcaact gttttctcgc 3254161 actcccgtgg cttccgacac tttcttcggt gcagtacatt ccgtcatcaa aacccctttg 3254221 tttgatttct tcaaatgatg ttataaaagt ttacaactta tgtcatcatt atatagaaga 3254281 ggcctattaa ttcaaagaat atttaaaaaa tttagttacc ttgaccaaat cagcttcttt 3254341 ttttgttata tttattcaca tcagaaaaag cgaaaaaaaa agacaagaaa catttcgttt 3254401 cctgcctctt ccgtacgatt aatctttatc tgaaaattta tccttggctt tcccgatatc 3254461 cttttggatt tcgccttttg ccttatcttt tttgccttca gcctgcatgt ccgttctgtc 3254521 agccatatct ccgactttat ccttcacttc tcctttggct ttattgaagc cgcccttcat 3254581 tttgtctttt acactatcgt tacccatgtt aattctcccc tctcaattat gtgtgtactt 3254641 gttaacttcc cgatctgaga ggcaataaac attctaatgt tatttatcga tttcgtagcg 3254701 ctctccgtaa cggagcacct tgtatatcgc cagcccgtct gatgactttt tctccgaata 3254761 tcggaccggc agcagggcaa aaaacacata atacgtagaa aaatagacaa actgatagaa 3254821 aaacacattc ggctttaata cactgtgtat aatcagcaga ttgattgcaa aaatcgtgat 3254881 gaggttaaac aagcagcccc ctgcatacac gagtgcattt gagaatcgat tgtcaatttt 3254941 caactccccg taccggcaaa aagaatcgat aaaataaatc gttctgaacc gtatgggtcc 3255001 aattttaagc agcgtttttc ccatgcctat atccaacgat ccctttccgc caaaaataaa 3255061 agccataaag ctgtgccctg aaacatgtat aatctgtaca agcggcagaa caatgaggaa 3255121 agaccacaga aacttcacca tatcattaaa accaaacatt gaattccccc tcacatgcat 3255181 atctgcatcc caaaacggct tttgttcaaa aaacagtgct gtagcgattt ttcctgttct 3255241 ccccggaaat aaacgttccg atgctcccct ttttttgcat aaaaaaaaac catctgccag 3255301 cagatggttt tgtctcatac ttcatataaa caatcgttcc tttgaatcat ctctctcatg 3255361 ctgaccgctt tttcataaaa atacaccgct tctttatatt gttcgcgatg actgaaataa 3255421 gaggcagcat ctaaagcaaa ttcttcaata tatacataca ggcccttttc ttccatataa 3255481 tcaaatactt cttgaatcat attcaaattg acagattcca catataatgc ctgcagaaat 3255541 ttatattttg ccagactgaa gaagtcgttt cgtttttggg caatggcaat ccctttttca 3255601 tagtaccgta tcgcggcttc gctatcttgt tttttgaaaa gaacgcgagt caggctgaag 3255661 agcgcttttg gaagctgttc cagctgataa tcctcgaaga caggaagcgc tttttcaaag 3255721 tattcggcgg cctgatccag ctcccccttg tcatcatagc aattaccaat attataaagg 3255781 gctgatccga tcaaacgggg ctgtccttcc aataaagcaa ggcgatacgc gtcatctaaa 3255841 tgttcaagcg ctttttcata atttctgtag tcaatgtagt ttcctgatat gacgaaatgg 3255901 cattgaattc ttctgactct gtaaaaatcg tgagccttat acgtctccag cgcctgtacg 3255961 gcatggttca tggaaaagtg cgtctgcttc ataatataaa agacttccgc cactttaaaa 3256021 tgaaattccg ctctttcaat ttcatcttct acaaacgcaa gcatcttctc agctttccga 3256081 taaaaggata tagccgagat gtaattgttc tgttcaaatt cgtacattcc tctaaacaag 3256141 tgaaaataat actcagataa tccggagatg ctgtcctgat tgctttccag cgttttgatc 3256201 aattcacgat attgaagctg agattcctcg tgcaggtcag gctttacata atccagcata 3256261 atttggtgcc ggtagctgat cagctgataa tacaggagaa gcagctgatc ctcttccatc 3256321 tgttcgatat ctagatcaat ttcttctttc agttttacgg catcagccac ttgaaatgct 3256381 aaaatgtgct tataccactt attgattttc actcctactt gagatgacgg gatctcgtac 3256441 gcggccatgc ccctccaacc ctttctattt tctaattggt tatattttat cataatgtat 3256501 ggctttggaa ttaaattttc ttacaatgat tccttcttta tgcctatcct tatatatttc 3256561 ggtttttcta cgtatttttt gcactcggat tctaataaaa aagcttaccg gacagtgccg 3256621 ataagctttt gacttcaaat taaccgccaa tataagacat ttccactttc tttttgccag 3256681 atgcttttga tagcgtacga tcgactgaat actgatcgat ccgatttttc catactgtcc 3256741 cgatcatttc tgatagttcg tcatcactta attcctggcg aaccggagct ctgaggtcaa 3256801 atccgcttga agcgaataag caggtaaaca gctctcctct cgcagaaaga cgggctctgt 3256861 tgcaagatcc gcagaatgca tcagatacag atgatatgac gccaatttct ccggagccgt 3256921 ccaagtagcg gaatctggaa gccacttcgc ctatataatt aggcgctatc ggctcaaccg 3256981 gcatgtgttt attgatcaaa tctatgattt ccgcctttgt catgacgtct ttcttttccc 3257041 attggttggt gttgcctacg tccataaatt caatgaatct caggatatgc cctttttctt 3257101 taaaataacg ggccataggc agtatatctt tttcattgac gcccttttga acgaccatat 3257161 tgattttaac accgagcccc gcttgcttcg ccgcttcaat gccttccagc accttgctga 3257221 cagaaacacc gcgcccgttt atcttcttaa aacgctcgtc ttctaaagaa tcaaggctga 3257281 tcgtaaccct tttcagccca gcctccttga gcctcttagc ataaacaggc agcagtgatc 3257341 cgtttgtcgt catcgcgatg tcacgaatac ccggtatgcg ggccagtttt ttgattaatt 3257401 ccggcatatc ctttctcatg aggggctctc cgccggtcaa gcggattttt tcaacgccaa 3257461 atcttgtgac aaacaatgtc gcaagccgtt ccagctcctc aaatgaaagc agctcctctt 3257521 tctttaaaaa aggataatcc gggccgaata attcggcggg catacagtac gtgcatcgga 3257581 agttgcagcg gtctgtaaca gaaatgcgaa ggtctctcag cggtctgttt cttttatcca 3257641 acatctgacg cgactctgta atcatagcta cagccccttc ctactccctg attctctcag 3257701 ggtgtgtata tacattaaat gatccgtttc tgacaaatcc aatcgctgtg atattcaatt 3257761 cttcagccat ttgaatcgca agctccgtcg gggccgattt ggaaatgaca atcgacacgc 3257821 cgattttggc cgcttttaac aggacctctg atgagattct gccgctgaac acaatcagtt 3257881 tgtcgcgtac ggacatcccg tttagaaggc agtgtccgta tagtttatca agtgcgttgt 3257941 gccgaccgat atctgtgcgc atcaacagaa gcttctctgt gtcgcaaagc gccgcattat 3258001 ggacgcctcc cgtatcctga aacgtcccgc tcccttgctg catgtctttc ataagcgcca 3258061 gacatgcctc aggcgatatc ttgatttggc tgacagccgt cttggctgtt ttgacatcct 3258121 gctgaaaata aaaatgacgg ccctttccgc agcatgagcc gatcacccgt ttcgtataat 3258181 ccttttgatc caatgtctca gggtgaacga ggtcgacata tacaaaaccg agactttcat 3258241 ctattgtaaa ccttttaatt tctttttgaa atcgtataac accctctgat gcgagaaatc 3258301 cgatgacaag ctcttcgata tgctcaggcg tacaaacgag cgtcacaaat tcactgccat 3258361 tcagtatcac tgtcaaaggg aattccgtca ccatccggtc ttctactttg cttatttccc 3258421 cttgttcata gcgccataca tccctgaccg cagttacttt atcgttcaat gtctcttccc 3258481 ctccgcaatg ttcctgcctt tatatttttt cacactcctc ggattttgtc gaattctgag 3258541 acacaaaaag agccctctat ataaagggct tttacaggat gtgatgacgg cggtgtttag 3258601 gcaggacgcc taagcattta gccgccgttc cttttataac acgtgagcac caatgtgcat 3258661 tgacaacgaa cgcggggttt gtcgacacgc tgagacacct ctgtataaag gactctatgt 3258721 ttgattatgc tgattctttt tcagaaccgt aaacagcaca atagctgcga tcaaggtgag 3258781 aatgctgaca aaaaagaagg ctgccagttt tagaagaaca ccaagcaata taaatgcaac 3258841 ggtggctata agaaaaatca ttccgaataa tttcatatgt tcaacccctt tttagggtat 3258901 cattcccgcc caaactgttt ttaaaccaat aaaaaaggcg cctgggggag cgcctgatct 3258961 ttaggttcct tactcagtaa atttttgtgc ttctttttcc caagcctgtt cgaactcatc 3259021 cgcactgttc gctgaaatat attctccgcc gccagcgaca gctgcttgtt tcatctcttc 3259081 attacccttg acatcaaagt tgaagccaat gatgtttaca atcgtatcca catttgatgc 3259141 acggagcttt tcgatttccg ccgcagggtc tccgccgcac gtttcttcac cgtcagtgat 3259201 taaatacacc acgtttttcc cgtctgcgtc aaatgcttca aattcttttc ttgtgtctgc 3259261 aagtgctttg gcaatcggtg tccatccagt cggcttgagc tcactcaatg aattgtcaaa 3259321 cagagaccct tcatatggat gaaggccgta aatggtttcc gtcgtactgc acgaaagggc 3259381 tttaccggac agtttattgt tccctgcatg cccgaaaacg cgaagcataa gatttgtatc 3259441 ctttggaaga agttcggcaa aagattttac tgattttttg gcaatgtcta ttttgcgctc 3259501 tcctcctgtt ttttgaacca tgcttccgct tccgtcaaac aaaacagcta catttgtatc 3259561 agcctgtttc tcagcggcaa aagacgggga ggcaatggaa acagtcaaca atccaatgat 3259621 accggcagcc agcaattttt tcatatgatt acttcctttc tttttcatat tttccaacta 3259681 tatgttggat tcttctttat gctagaatac gaaaatgcaa aaagatatag gacatgctgc 3259741 cttttgtgct gctttcacga tctgtccaaa atcgcttgaa atgccgttca tttttagcca 3259801 tttccgccca gaaagcataa acagcttgtg tgatcattca ttcttttttc gccttgatta 3259861 tgacagaaaa acggaaatct gctactatgc tacaggcaga cagctaatta gttttgaagt 3259921 ttttgttaca tacaaaaaga ggctgaccat caccagcctc ttttttctta tttagataac 3259981 attagtgatt gctgagtgaa aattttctca acatcttttt gggtataagc cgggaagtat 3260041 tcaccgccgc ctactttcgc aattgcgttc agctggcctt tgtatccctc tttataatca 3260101 aagccgatca cattaacagt gatattgtct ttttgcagtt cctttgctgt tttaatcggg 3260161 tttcctccgc acgtttcctc accgtctgtc aacagataca ccactttttc cccttttgca 3260221 tcaagctggt caaaagaaga tttcgcctcg ttcagcgctt tggcaattgg cgtccagcca 3260281 gtcggcccaa ttgtattgag agaattgagg aagctttgct cgttaaagct ttggaagccg 3260341 tatacgttgc gaatggcttc acatgactga acttttccgg aatttttatt gtttccttca 3260401 gagccaaaca cgctcatttt cacctgagtt ccttctggca atgagctcgc aaactttgaa 3260461 atttcttttt tggctgaatt aaatttagat acaccatcta ttcttttcgc catacttccg 3260521 ctggcatcaa gcaagaccgc cacgttcgcc ggcgctttag cctccgtttc tgtcttttca 3260581 gctgcaaaag caggtgaagt taatccaaaa agcaatcctg tcatcatgat cagtgaaaat 3260641 cttttcttca tgttcgtacc cctttaccaa tttgtttctg cgtgcagatg ttcaacgctg 3260701 aacataatct atcgtaatca acaaaaaccg agaaataaat agggcgggct tccccattgc 3260761 tgttgtttac ttttgcatag aaacctatgt ttttattagt gatttccacc taacgcccct 3260821 atgaaaagag aagattgtcc gcctttcggc tttcgttata tgagtctgtc gaagtctgtc 3260881 gacaaatgtg gatgacttta ccacaatctc aaagcctgaa atcaggaaaa aaggactgat 3260941 ccttaaagac ggtcagaagc tcctctaaac cgtttcagct actcttagat aaaagatatt 3261001 caggaacaga aaaagacgcc caatgagcgt ctttttctac tttttcgcca tatatttatt 3261061 caaaaacgca tctgcctcag aaatttgtgt gccttggtaa tagtacttta caatgtcatc 3261121 aaccgttttg ccttctttgg ccataaaatt cgctccgtat tggctcatcc ccacaccgtg 3261181 gccaaatcct ctcgtcgtga ctgtaattgt gtctccattt cgcttccatt caaaatcggc 3261241 ggagttgaga cccaactttt cacgtatgtc tcttcctttc agcgtcttgc cgttaatgac 3261301 ggcagttgcg acctggtggc ccggtgtctc gccggtaatc ttccctactg cgctagatcc 3261361 atccagcttg acgccaagct tttgctgaaa ttctgccgct gtaaaggttt tcgttgcctt 3261421 atatttcgga gactttttat cccatgggct tttgacgctt tttaaatatg ggatagcact 3261481 tgtccaataa gcttctgcat tctctgtgta gccgttgctt gtggagaaaa aggatgcttc 3261541 aatcggctgg ttgttgtacg ttaagatttt gccttgcgta ctggctaccg catctgtgat 3261601 tttcttcagt tttgtctcat agcttgtgcc ccactgtttt ttcagctccg ctttgctttt 3261661 atacacctgg aacatctgtg tatcatccac cagtgagcct ttaggagctt ctaccgctga 3261721 atttgacacc atcagtctga caataaatgt tctggcggca agcgcctggg ctttcagcgc 3261781 ttcaggttta aaggttgccg gcatttcgga ggcgacgact ccaatcacat actcttcaag 3261841 cggaatgttt tctacggatt gatttgcggt tcgatagacg ggaatagaaa caggtgatgc 3261901 tttcaatgtt tctgctcctt tcgatgctgg tttcgtgctg actgctgtct tttctgattc 3261961 tacgctggcc cccgcttcct tattatgctg gaatggtata accaagagtg tgggaaccaa 3262021 gagaatcaat gcacatagta cggatagtgt gattgcgaat tgtttcatat tcagctgcct 3262081 cctgctcggg attcgactct agtctagtct atgggcaggg acaagctaat atgactctcg 3262141 ttttggacag aaactttatt tgtcatttac gtattctttt ttgctatttt gcgcataatg 3262201 atgataatac acaaaaaata aaaaaccagt atgccagagt gacatactga ttttcaagta 3262261 agtttatgca tttaagtcag aaacgacttc tttattctct tgctcagaag cagactcatc 3262321 atttacacgt tcgatgtctg cgcccagagc ggcaagcttc tgatggaaat caacgtaacc 3262381 gcggtctaag tgcttcaatt cagtaacacg tgtgtgacct tcagccacta accccgcaag 3262441 aatcagcgct gcacctgcac gcaaatcagt cgctgcaact tcagctccct gaagctgtac 3262501 aggaccgtta atgatgacag aacgtccttc aatcttgata tcaccattca tacggcggaa 3262561 ttcttccgca tgcataaaac ggttttcaaa aacggtttct gtaatcatgc ttgtgccgct 3262621 tgcacgaagc agaagcgcca tcatttgtga ctgcatatca gtcgggaagc ccgggtgagg 3262681 cattgttttg atgtcaatcg gtttaagctc tttcgggccg atgacacgca gaccttcacc 3262741 ttcatcctta attgttacac ccatctcttc catttttgca attaaagagg tgaggtgctc 3262801 aggaaccgct ccttttacta atacgtttcc ttcagtgatt gcagcagcaa ccataaatgt 3262861 gcccgcttca atacggtcag gaataatatg gtgttttacg ccgtgaagct tttcgactcc 3262921 ttcaattttg atggtgccgg tgccagctcc gcggattttt ccgcccatgc cgttgatata 3262981 gtttgctaaa tcaacgattt cgggttcttt tgccacgttt tccagcgttg ttgttccttc 3263041 agctagagcg gctgccataa tcaggttctc tgtagctcct acacttggga agtccagata 3263101 aatttttgcg ccttgcagtc ggccttttac ttcagcttca atgaagccat taccgacttt 3263161 gatttctgcg cccattgctt caaaaccttt taaatgctga tcaatcggtc tggaaccaat 3263221 tgcgcatccg cccggaagtg caactcttgc atgacctgta cgcgcaagaa gcggccccat 3263281 gacaagcaca gacgcacgca ttttacgaac atattcaaaa ggtgcttcag tttgcaaagc 3263341 gtatgaagca tttacagtca cttcattatt ttcaaaatgc acatctgctc ctaaatgacg 3263401 caacacttcg ttaattgtat atacatcgga gagcgtaggt acatcacaaa ttacgctttt 3263461 ttcttcactt gctaataaag atgcagcgat aacaggtaaa acggcatttt tagcgccttc 3263521 aactttgact gtgccgttta acttctgacc gccgcggacg atgatttttt ccaaggtatt 3263581 cccctccgcg tccctaaatt ctctatatta atattcagtc gtaacgattg gtgtgccaac 3263641 cgtaacggta tgttttccgc ccattcctgc acttctaagt gcaatttgca aattcatttt 3263701 atgtttcgag gtcataatgt actcttccca ctcatctgta aacgcagaaa tagaaacgaa 3263761 atttggctca actacatgtt ctactgatct tgcttgaaat tcatttaata actgatttgc 3263821 ttttttttgc aaaacaatat tcatattatc atctaagtga ccatttagac aagtaaaaat 3263881 aactactttt tcttggaata tcccaagtgt ctcccgttca aactgttcat atgtatcatt 3263941 ccagctatcc ggtgtctcta gactcatttg ctcatataat aaatacgaag ttggattgtg 3264001 ttttttgagg gttgtgacaa gctgcagtct aaaagaagta cgattttttt tgtcagtata 3264061 tgtgccaatt gcctttatca ttttatcttc ccgtgcaatc acccaatcat attgacgata 3264121 ctcttgtttt aaacgttgca ctttttgata aaattctttt tcggtcagtg acaagttttg 3264181 ttttgcatgc aatgtccact tatctattga cacatcttga cgttccatcc cctctgccat 3264241 ctgtgctaac ggcgttaatt cactcgcatg aatggtatgg aaaacagcaa tgacgaagct 3264301 taacatgacg gaaatgataa tagcgtggct tacttgtttt ttcttcatgt tcatctctcc 3264361 cccttatccc cagttttacc ggaggcaaga ggcgccatac gtaaaaatct tcgtcaaaac 3264421 tcgagctatt cgcttcaacc cgcttctccc aaccatttaa taatgttcaa aacctattaa 3264481 aatagatagg gaagctgctg tgaataattg aggtaatcta aaaagaaatt ggcaacggcc 3264541 gttccaatgg cgattgtcag caaaatcatc aggagtcttg cctgcacgac tttgcctttt 3264601 ttgattaacg gatctatatt gacggcttgc aacgcccacc aagtcactgc tataaaaatc 3264661 aggtgaacga caatgccgat tgcagcctgc tgtcccaata cactcatcta ttacactcct 3264721 ttctctgcgt tcataccctt tcttattata taagaagcac agataaagat gatacatttt 3264781 atacagaacg gaataatcag ccaaatctag ggctaatccc cgcttaaagt gcgattcttt 3264841 tacatggtat actttattgg aaaggagctg gcaaatgtga atcattcttt ttttcagcct 3264901 gaaaagcaat atggtgagga cctgccaatt tttgatcagg aatgggaagc aattgcattc 3264961 tattatgatt atagacagtc acagattgaa gaactgaatg aattgtgtca gttttttaac 3265021 atttctctta cctatacgag agaaagcctt gaagagcttg aaaacctcta ttttcaaagt 3265081 atacaagaac ttttgcttgc tgattggaat cttcctattg aagaattcga gaaaatgatc 3265141 agtgtttatc ttatagattg tgtgattgcc cgccatgaag atgctgaatg ggttgtaaaa 3265201 ccttatccct ataaagacgg cgcttataca cttggcttta gaagacatcg caaatcgtgg 3265261 catacaatga atgcctgtga tggtttatac ctgcgtccaa aagaggatcg cccgttgctg 3265321 tcgctgtttg attctcttgt gcgttcataa aaaaatcctt ctcataaaga gaaggatttt 3265381 ttcttatttc cctgctacat ccaatctgtt caaagcccgc tgtaacgcaa gctcagcccg 3265441 acgaatgtca gtatcatctg attgagaatt caaacgctcc tgcgcccgct ggcgtgcagc 3265501 ttcagcgcgc tctttatcga tgccttccgc tgtctcggca gcctgggcaa ggatggtgac 3265561 atgatcagga cggacttcta caaaaccgcc gctgacggca accatttcag tctgcccgtc 3265621 ttttttcaga cggacagcgc cgattttaag aggagccacg gttggaatat ggcctggcaa 3265681 aataccgaga tcgccgcttt cggctctcac actcaccatt tcgatatccg catcgtatac 3265741 tgggccgtcg ggagtaacga tattgacttt aacggtcttc atgcttttac cctcctagga 3265801 ccagattaaa cttctacacc catttctttt gctttctcaa caacttcttc gatacggcct 3265861 acaagacgga atgcatcttc tggaagatgg tcatatttac cggctaagat ttctttgaag 3265921 ccttgtaccg tctcttttac aggcacgtaa gaaccttttt gtccagtgaa ctgttcagcc 3265981 acgtggaagt tctgagaaag gaagaactgg atacgacgtg cgcggtgaac gacaagtttg 3266041 tcttcctcgc ctaattcatc cataccgaga atcgcaatga tatcctgaag ctctttgtaa 3266101 cgctgaagcg ttgactgtac ttcacgcgca accgcatagt gctcttctcc aacaatttca 3266161 ggagcaaggg cgcgtgatgt agatgccaac ggatcaaccg cagggtaaat acccatttca 3266221 gttaatttac gctcaaggtt tgttgtcgca tccaagtgag cgaacgttgt cgccggcgcc 3266281 gggtcagtgt agtcatcggc aggcacgtag atcgcctgga tagatgtaac tgatccaacg 3266341 ttcgtagacg tgatacgctc ttggagctga cccatctcag ttgcaagcgt cggctgataa 3266401 ccaaccgctg aaggcatacg gccaagaagg gctgaaacct ctgaacccgc ttgtgtgaaa 3266461 cggaaaatgt tatcgatgaa gaacagtacg tcctgtcctt gtacatcacg gaagtgctca 3266521 gccattgtaa ggcctgtcaa agcaacacgc atacgtgcgc ccggcggctc gttcatttgt 3266581 ccgaatacca tggctgtttt gttgattacg ccagagtcac tcatttcgta gaaaaggtcg 3266641 ttcccttcac gagtacgctc tcctacgccg gcgaatacag agataccgcc gtgctcttgc 3266701 gcgatgttgt tgattaattc ctggattaat acggttttac ctacaccggc accaccgaac 3266761 aatccgattt taccgccctt aatgtaagga gcaagcaaat caacaacttt aatacctgtt 3266821 tcaagaattt caacttctgt tgaaagctga tcgaatgaag gcgcctgtct gtgaatcgga 3266881 tcctttttcg catccgcagg aaccggctca ttcaaatcaa tattttctcc gagaacgtta 3266941 aatacacgtc caagtgttac atcaccaacc ggtactgaga ttggcgctcc tgtatctaca 3267001 gcttccatac cgcgctgaac accatctgta gatgccattg cgattgtacg gactgtatca 3267061 tcacctaaat gaagagcgac ctcaagcgtt aaatcaatac ctacttcgtt ttcacttgca 3267121 gctggctgtg aaattttaat cgcattataa atttcaggca agtgaccgtc ttcaaaacgc 3267181 acgtcgacga ccggtcctaa tacctggcta acgcgtcctt tcttcatcgc tatccctcct 3267241 gacaaaatct ttctattcta aagcggctgc tccgccgaca atttccgtaa tttcttgtgt 3267301 gatggctgct tggcgagcgc ggttgtaaga aagcgaaagt gaatcgataa gttccttcgc 3267361 gttgtctgtc gcgtttttca tcgccgtcat tcttgcagcg tgctcacttg ctttactgtc 3267421 aagaagcgca ccgaagatta agctttctgc atattgagga agcaaaacct ccagaacctc 3267481 ctcttcagat ggttcaaatt cataagacgc cgttcttttt ccgccgccgc tgcccaaatc 3267541 agataacggc agaagttttt tctccgttac ttcttgagta atggcgctga caaaatggtt 3267601 ataaacaagg tgcaattcat caaacgcacc gtctataaac atttgaatcg tttgacgggc 3267661 aagatcttta atttctgtaa acgttacttc atctccaagt cctgttaact cggaaatgat 3267721 cggaatctcc cgtttcttaa agaaatcacg gcccactctt ccgatggcaa tcaccgcata 3267781 ctcatcctta gactgatgac gttcttgcat ggcctgataa gcactccgta aaaccgaact 3267841 gttaaaagcg ccggcaagac cgcggtcaga cgtaatgaca aggtatgccg tttttttcac 3267901 ttctctgctg agaagcatcg ggtgcttcac gttgccggaa actcttccga cgtttgacac 3267961 aacctcttgg attttatcca tatatggcac aaatgatttt gcattgtttt cagcacgatt 3268021 cagcttagcc gcagatacca tctgcatggc ttttgtaatc tgacttgttt ttttcgttga 3268081 cgtgatcctt gacttaatat cgcgtaatga ggccaaagat ttcaccacct tttctcttca 3268141 tctgcgtaaa aagagagaaa aagagaacct ttttctctca tcagcattcg agttagttgc 3268201 ttggtgcaaa tgtgcgtttg aagccttcga ttgcagcttt gaagtcttca tcagcaggaa 3268261 ggtttcctgt tttcgcaatt ccgtcaagca ggtctttatg gttttggtca aggtacatgt 3268321 agtactcttc ttcaaaacgt ctgatatccg ccacaggaat atcatcgaga tatccttttg 3268381 tcagcgcata aagaatagct acttgctttt caaccggaag cggcttgttc agatcctgct 3268441 tcagcacttc aactgtacgc gcaccgcggt tcagttttgc ctgagtcgct tggtcgaggt 3268501 cagaaccgaa ttgagcgaat gcttccagct cacggtatga cgcaaggtca agacgcaaag 3268561 tacctgatac ttttttcatc gctttgattt gcgctgagcc gccgacacgg gatacagaca 3268621 atccggcatt gatcgctgga cgtacgcctg agaagaacaa atcagattgc aggaagatct 3268681 gtccgtcggt gatggaaatg acgttcgtcg gaatataagc agagatatct ccggcttgtg 3268741 tttctacgaa cggcagagct gtaattgatc ctgcgccttt cgcgtcgcta agctttgctg 3268801 cacgctcaag cagacgggaa tgaagataga atacatcccc agggaacgct tcacggcctg 3268861 gcggacggcg aagaagcaag gacagctcac ggtaagcggc cgcttgttta gaaagatcat 3268921 cgtatacaac aagaacgtgc ttgccgttgt acataaattc ttctgccatt gtaaccccag 3268981 catacggtgc caggtacaga agcggtgccg gctgtgacgc agacgccgtt acaacaattg 3269041 tataatcaag cgcgccgtgt ttacgcaatg tttctactac gccgcggact gttgattctt 3269101 tttggccgat cgcaacatat acacagatca tgtcttggtc tttttggttc aggatcgcat 3269161 cgatcgcaac agatgtttta cctgtttgac ggtcaccgat gatcagctca cgctggccgc 3269221 ggccgattgg aatcagtgca tcgatcgctt tgataccggt ttgaagcggt tcatgaacgg 3269281 atttacggtc cataacgcct ggtgcagggc tttcgatcgg acgagttttg cttgtcagaa 3269341 tcgggcctag tccgtcaacc ggctggccta gcgggtttac aatacggccg attaactctt 3269401 caccaacagg aacctccatg atgcggcctg ttctttttac ttcgtctccc tcacggatct 3269461 cactgaaagg tcctaagatg acgataccta cgtttgattc ctcaaggttt tgagccatac 3269521 ccaaaacacc gtttgaaaat tcgacaagtt caccggccat acagttgtca aggccgtgca 3269581 cacgtgcaat accgtcaccg acttggatga ctgtacctac gtcttgaact tcaatatcag 3269641 attgataatt ttgtatttgc tgttttatca gcgtgctaat ctcttcagct ttgatgctca 3269701 cttaggtttc accccttcta tcgattttcc ccggctaatt gacgttcaat gcgctgaagc 3269761 ttcccgctta cgctgccgtc ataaatccgg tttccaatgc ggactttaat accgcctatt 3269821 aaatccgtct gcacttcatt tctgattctc agtgaagcga ctccggcttt ttttgcaaac 3269881 acttgtgata atggtaacat ttctgcatcc gtcagcggtt tcactgaata tacgattgcg 3269941 tcttctgttt gacgggccac atttgcgagt ttgataaact catctgtgag ctcagggaca 3270001 atcgcggcac gatggcggtc aatcaaaaga aaaatcgtat tgagtacgga ctgtgacaaa 3270061 gagccaaatg cattttgaat cagctctttt ttcttcgcag ccggcacctt cggatggttc 3270121 aacacatcat taagcgcttt ttcattttga aatacttgtt ttacaacaat tagctcttct 3270181 tctacttgat tcagctgagc ggactcattg gctatatcaa aaagagctga tgcatatcgt 3270241 ttagagacag ctgatccact catcggcttt ctcctacctc tttaagatag tcctggatca 3270301 atttctcttg cgcttgttca tccagttctt tttcgatcac tttcgacgca atcatgacag 3270361 aaagagacgc tacttgctca cggagagcag aaaccgcctg ttccttttcc ttcacgattt 3270421 cagttcttgc tgcttctttc agacgttcag attctgcacg tgcagcctga ataatctctt 3270481 ctttttgctt ctctcccagt ttctttgcgt tttcgataag agtttgggat tcctgtcttg 3270541 cttcttttaa aagaacgcgc tgctcttcaa tcagctgctg cgcttcttta tttttttctt 3270601 cagcagacgt aatttctcca gcgatgtggt cttcacgctg tttcattatg tttaatagcg 3270661 gccctaaagc gtatttcttc agaagcgcta ataagattaa catagctaac agttggaaca 3270721 ggatatctcc gccgttaaac gacaatccta gttcaagtgg taattgagac atctactacg 3270781 gcaactccct tctgcaggtt tttctttgct gatccagcag ccgcacttgt ctcttttcag 3270841 ccggcaaggc gggatgctta tcagacataa agcaatggcg aaggttctct tggaatgatc 3270901 ttcgccattt ttagttcata taaggctttt atgcttagcc aaagaacgct aagaatgcga 3270961 taacgacagc gataatagga agggcttcaa ctaatgcgat acccatgaac ataagagttc 3271021 tcagttcttt acctgcttcc ggctgacggg caatcccctc taccgtacgt gaaacaatca 3271081 aaccgttacc aatacctgca ccaagtgcgc ctaaaccaat tgcaatcgca gctgctatta 3271141 aattcatgaa aaagttcctc ctttaaaatg ttatccgttt ggatataatg ttttaatgat 3271201 catgactgat tttatgagac atgtacacca tcgtcagcat tgtaaagata aatgcctgga 3271261 tagcaccaat aaataaactg aatgcttgcc atgccagcat cggcagaatg gcaccgattg 3271321 taccgacaag accgagagcc acgctttgcg aataatggct tgttgctaat cccgcaagca 3271381 ggccgagaag aatctcaccg gcgaagatgt taccatacag ccgcaaacct agagtcagcg 3271441 tattcgcaaa ctcttcgatg attttcatcg ggagcatgaa tggaacaggt cttaaatagt 3271501 ctttggaata ttccttgagc cctttcatct tcacaccata gtagtgggtt aaagcaacaa 3271561 ccatcacggc tagcgttaat gtaatggcag gatcggctgt cggagacttc caccagagct 3271621 catgtccgat tgtaatagag aacggcagcc ccagcatatt cgacacaaat atgtacatca 3271681 gcaatgtgac accaagtgcc aagaagttag cccctgtttt taaatccatt gtactgccaa 3271741 taatattgcg gacgaaatca acaatccatt ccataaagtt ctgggctttt ccgggacgga 3271801 tcgaaagcgt tcttgtcgtc aatatagcaa tcaataaaac aatcacactc gccacagtaa 3271861 tcatcagaat gtttgtcaga ttaaaagtaa gacctagaaa ttctatagtt ctgtaaccat 3271921 gattcaaagg gttttcacct ctcttccatt gatgaacgtt taagctggat aaaggaatct 3271981 atcataatga cagggtatat tgtcattaat ccaataactg tacttgccat atgaaagtat 3272041 tcgggatttt tataggcaac agccacagca agaatcgcat tgcaccaccg cgctgcgctc 3272101 ccgagagatc gtatggactt tcctttctct acagctctgt caaaagcatt cattcttctg 3272161 acgagcagta aaaaattaaa caaactgaaa acagttccca gaataaggcc taaaaaaacg 3272221 gttttatacg ctgttaaacc ataacccagt acatacactg ccaaaatgaa caataaatat 3272281 ttgcgttgtc tgctaaatgt aagcttggga tcgtccatca attatctgtc tcctgatgaa 3272341 aaaataatgt atagcttgga tacggcaaaa atcagcggtt aacccttagt agaagacctt 3272401 ttttgaccgg caaaacgggc ctgttcgaaa aaatcattca tccgcaagcc ttgcagggat 3272461 gctgtttcat tcgcttaaat aaatcctcat aatacgggtt tgctgagagg atttacattg 3272521 aggatgagga ctataatgaa agctatgaaa accttctcat aataccctcg tttagcatac 3272581 aatagcccct aacatgtgtc aatctgttta aagttaaaaa actttttata ctttacgtct 3272641 ccacagaatg ttcacatttt cacctataat tgtatacaga ttcaccgaat agcaaaaaac 3272701 tggataaaaa aatgaaaccc ccttttgggg atttcatttt ttattttgtt ccaaacatgc 3272761 ggtcacccgc atctccgaga cctggaacaa tatatccttt ttcatttaat ttttcatcta 3272821 gcgccgcaat gtaaatatca acgtccgaat gatgcttctg caattcttcc acaccctccg 3272881 gcgctgctac aagacacatg aaacggatat ttttcgcacc gcgtttttta aggctgtgaa 3272941 tggcttcaac tgcggaaccg cctgtagcga gcatcgggtc aaccacgatg aattcacgct 3273001 cttccacatc agaaggaagc ttgacatagt attccacggg ttttaaggtt tctggatcac 3273061 ggtaaaggcc gacatgtccc acttttgccg caggaatcag ctttaaaatg ccgtcaacca 3273121 ttcccaatcc tgctctgagg ataggaacca ctccgagttt tttccctgag atgactttcg 3273181 atttcgcagc ctgaaccggt gtattgatat ccacttcttc cagaggaaga tcgcgggtaa 3273241 tttcaaatgc catgagtgta gccacttcat ctactaactc tctaaaatcc ttcgtacctg 3273301 tattttcatt ccgtatatat gtcagcttgt gctgaattaa aggatgatca aatacataaa 3273361 cctttcccat actgtgtttc agctcctttt ttattgtccc atcaacaatt acacacttct 3273421 attgattcta caaaaaaaga cattgagttt caagaacatc gtcaaaaaac ccgccgggca 3273481 taagcccaag cgggttttag gatcttaata atctaattct ttatataaag gaaatttatc 3273541 agtcagagca gctacacgct gtcttgcttc ttcaagtttt ccttcatctt cgtggttttt 3273601 caatgcaagc gcaatgatag caccgacttc ttctaatgcg tctccgtcaa aaccgcggct 3273661 ggttacagca gctgtaccaa gacggatgcc gcttgttacg aaaggttttt caggatcata 3273721 tggaatcgcg tttttgttag acgtaatacc aatttcatca agtacatgct ccgcaacctt 3273781 accagtcagt ccgagcgaac gaaggtcaac aaggataagg tggttgtctg ttccgcctga 3273841 aacgagctgg atgccctctt tcgttaaggc ttcagccaga cgtttcgcgt ttgaaatgac 3273901 gttttgtgca tatgttttga aatcgtcctg caatacttca ccgaatgaaa cagcttttgc 3273961 ggcaataacg tgcatcagag ggccgccttg aattccaggg aagatcgatt tatcaatttt 3274021 cttgccaaac tcttcacggc aaaggatcat accgccgcga ggaccgcgaa gtgttttatg 3274081 tgttgttgtt gtaacgaaat cagcgtaagg aaccgggttt ggatgaaggc ctgccgcaac 3274141 aagtcctgcg atatgtgcca tatccaccat gaagtaagcg ccgacttcat cagcaatttc 3274201 acggaatttc ttaaagtcga ttgtacgagg atacgcactt gctcctgcta cgataagctt 3274261 cggtttatga gcgagggctt tttcacgcac gtcatcgtaa tcaatatatt gagtttcttt 3274321 atctacgccg tactcaacaa agttatattg aacaccgctg aagttgactg ggcttccgtg 3274381 tgttaaatgg ccgccgtggg agaggttcat cccaagtaca gtatcgcctt gctccaaaat 3274441 cgtgaagtac actgccatgt ttgcttgtgc gcctgaatga ggctgaacgt ttacatgctc 3274501 cgctccaaag atttccttcg cgcggtcacg ggcgatatct tcaacgacat cgacgtgctc 3274561 gcatccgccg tagtagcgtt tgcccggata tccttctgcg tacttatttg tcaaaacaga 3274621 tccttgtgct tccataaccg cttcacttac aaagttctca gaagcaatca attcgatctt 3274681 agtctgttgg cgttcacgct catttttaat ggcgttaaac acttgttcgt cttgcgcagg 3274741 taaatgtttc atcagcgaga tcctctccta tccgtatcct gttctttgtt tttaccatca 3274801 ctattgtaca tggtttttaa ggccgatgta aaagattatt tttaaaaaat ctaaattttt 3274861 attggtaaaa acgaatatta ataacttaaa tttaatttaa agttcggaat ttatttcact 3274921 atcttaaaat aaaagaaaag actggctatg cagtcctttc attcgcactc ataaaccgcc 3274981 cgcactccgc cgattagttt cggccgtgta cgcgccaatg tcacatgagc tgaaccgagg 3275041 ctgttttgag agacacgcac agggacagcc accggtttca gatgcatgcc gataaacgta 3275101 tcgcctatat caattccggc gtcagcctga atggtttcaa caagaacagg agacttcatc 3275161 tgcttaaacg cataagacgc catcgctccg cccgcttttg gaacgggcac ggcagaaacg 3275221 gttggaagcc tgaacagctt ggctgtttct gcttcgacga caagcgctct gtttaaatgc 3275281 tcgcagcatt gaaacgccag atggattccc gttttttccc ggagctcagc aagtccgctg 3275341 tagatgcttt cagcgatatc tacactgccc gatgtgccga tccggctgcc ggccacttcg 3275401 ctcgtgctgc atccaaggac gaagagctga tcttgtttca attccgcttg gtcctgaaac 3275461 tcagacagca tcgtcttcca cgtttgtttc aactcattca ttaaacagca cccctacagg 3275521 tttttctctt cataatcgga gatttttcca atacgcgttt ggtgtcttcc cccggtaaac 3275581 tcagtagtca gccagatttt tgcgatttcc cgagccaaac caggtccgat cacccgttca 3275641 cccatcgcaa ggatgtttgt gtcattatgc tccctcgtcg ccttcgcgct gaaggtatcg 3275701 tgcgccagcg cgcagcgaat cccttttact ttattagcgg aaatgctcat gccgatgcct 3275761 gtcccgcaaa ttaaaatgcc tctgtcaact tcgccgctaa ccactttttc ggccaccgga 3275821 aaagcataat ccggataatc gacagagccg ctgccgcagt cacagcccat atcaatatat 3275881 tcaatttgca attcgtccat taactctttg atttcatttc gaatgtgaac gccgccatga 3275941 tccgatgcaa tggctacttt catctgcttt tcctcccagc gtgtgtgatg cggcccgccc 3276001 gctttattga ccgcgcagcc tgtccgctct ttgattcaca ccatatgatg tgcttttcac 3276061 tatattctac tccttcacgc aggatttgca aatgacctgt ttgcagattt tctgacaact 3276121 tatctacggt cttttttcag ctgttttgcc agctgccgaa gaagctcttc aagctcatct 3276181 cgcgtttgtt tatagatgtc aattgagccg ccgaacggat cgaggacatc accatggctg 3276241 cctgtgacat attcttttaa cgtaaacact ttatcacgat aacgtccaaa ttggctggca 3276301 atgatctgtt tgtgctgatg ggtcatagcc agaaccaaat cagccgattc cataagttct 3276361 tcagttaatg gagaagacac atgattaagg gcaatgtgtt tttcaaacag cgcttcgact 3276421 gcatgaggcg tcgctttccc attaggtgaa gcaaacacgc ctgccgagcg gacattgaca 3276481 ttcagccctt ccctttctgc aattgattta aaaagcgcct cagccattgg gctgcggcac 3276541 gtatttccag tacagacaaa aataatatcc atgtcagtca ccccttattt ttctctatta 3276601 tatatgaaga aaaaagaaac ggcgacttcg tttcttttat tggtatatta aattggcaaa 3276661 agcagcttta atccaaacac gattaatatg atgcccccga gcgcttcgct gtatgtgcca 3276721 agccatgact gcacttgttt tccgaccagc aggcccagcc atgtcaacat catgctgaac 3276781 agcccgaaca gggtaattgt gaggagcgga tgcgagccgt atatccccaa gctcaagccg 3276841 acggaaaagc tgtcaaggct gacgccgatg gcaaacagca ataagcccgg ccctgccggt 3276901 gacatgaatc gttcttctga ctgtttaaaa gaggccataa gcatttgaac cccaagaaca 3276961 aaaagcagcg ccccaccgat ataaaccgct aacacgccga ggagccctga cagcatgtta 3277021 ccggccgcca tccctgcgag aggcatgatg acgtgaaaga ggccgatgat gaaaccaata 3277081 tagaatatct gcttctttct aagtttgacc atgcccattc caaggccgac agaaaaagca 3277141 tccatcccta aagcaaacgc catgatgctt aatgtaatca gttcgcctat aaacaaatcc 3277201 gacatacata aataaccccc ttggacacgc cccgcttttt tagcctatgc gtgtccaaaa 3277261 agggttagaa catctgactg ctttcagcga atcactcttc ctccggcggc tttcatcagc 3277321 ctgttcataa tagcaagacc gacacctgta tccggaaagg attccgctat aatgaaatcc 3277381 accttattct catcaaagct gcgcaaagca tcatacagcc ctgccgcaac agtctcaagc 3277441 tgagcccgtc ttccgcagct cttcacataa tcagcggaat aaacgcccgc tttttcttct 3277501 gtcgtcagga caccgacccg tcttccaccc tgttgatatt cttgaatgag gtgctgaatg 3277561 cgctctgggc tgccttcgca aatggcaaga ggcgctgtcg gcgcataatg tgtatatttc 3277621 atccctggag aaatcggctt ctcgttttgg tcgctgagcc ctttatccac atggatcggc 3277681 ccgatcaccg cttcaatttg ttccttcgta atgccgccag gacgcaagag aacagggatg 3277741 tcgtccgcac atgaaagcac agttgattcg accccgattc cggtagggcc tccatccaca 3277801 ataccggcta tgcggccatc caagtcgtga gccacatgct ccgcttttgt gggacttggc 3277861 ttgcctgata gattggcgct cggtgctgca atcggcagtc ccgattcgcg aatcaatgca 3277921 agggcaagcg gatgatccgg cattctaatg gcaaccgttt caagacctgc cgttacacga 3277981 ggtgaaagcg catcaggttt gcaaggcaga atgagcgtaa gtgctcccgg ccaaaaccgt 3278041 ttcatcaatg ttttcgcctt ttccggcgcc gggcccgtta aatcctcaag ctggctgata 3278101 tccgcaatgt ggacaatcag gggattatcg ctcggccgcc ctttcgcctc atatattttt 3278161 ttgacggcat ccgtattttt tgcgtttgcg cctaggccat atactgtttc tgtcggaaag 3278221 gcaacgacct cattttctcg gagcaaagcg gctgcttgtg caatttgtgg atcatttgtg 3278281 gataactcgt cagttacatc cacaaaccat cttttcgttt tcatttctga ccaaactcct 3278341 tattcacaac aataaaacga ttgttttacg cgtgtaatcc ttttgaaagt ataaaagatg 3278401 tcctgtaata aaacaagcgt tatccacaaa ttgtggacaa cgctaataaa gaagtggata 3278461 agtatgtgta taaactgcac ttatccagac gcttttttca tcaaaacggc tccttctgtt 3278521 tgccgcgatt cacagaagtg atcagaagaa aacagctcct ccggtacact ctcagctctt 3278581 tcaaaaccca tggccgtcag aaagtccgca gaggaatgct gatttgctac taggtacacg 3278641 gttttgatct gatgcttttc gcacagcacc tccatgcttt gaaaaagcgt gacgatgtgg 3278701 ccttggtgaa gcttgtccga tatgacaagt gatcgcagca gcccctggtc acagcttatt 3278761 ttttcaatac cgaggcatcc ggcaatgttt ttctcactgt cctccagcat aagaaattga 3278821 gtgaagcctt ctttcacgcc ttcatagctg gtttttgcct gttttaaaaa tgcctcgagc 3278881 acatctccgt ctttttccct tgccacccgc agttgataaa acatccgttc accccgtttt 3278941 tgcgttcttt cttccaatct atgaggcaaa tctattttta gaccagatga ttaggaaaaa 3279001 aggtcggaaa tccattcgac taaaaagaat ttcacttctg tgccgtcttc tttttcttcg 3279061 ttctcttctt ttttggcttt ttccgcttta gcggttacgt cctcaagcac tttttcagtc 3279121 tgcttttttg aggcttcttt atcttcttgt tctttgacgg cttccccgtt agaaaaatca 3279181 agaaagcaga ggggcgggaa cagcacacac caccagttgg cgccgtctcc gtttccaagc 3279241 gtaatcaaaa tcgcttcata ctcaccagcg ggatatacca tgttgccgta aagctttgtc 3279301 ggaaacgaga ttttgtcaaa atcaacggat atcgactgat tcgctccttc tttctccatt 3279361 gtttcctttg caattgcttt gatttcaggc agctttgaac gaatcacgcg acgcgcttct 3279421 tcaatagaag taatatcctt tacccaagtt gtgatttctt tattcaccgc gtctcttata 3279481 tgacgtttta attgctggtc ttgatcacta tcgctgtttg ccagtattct caaacgaatc 3279541 gcctgatcag gtatgaccac cggctgattt tccgattttt gtgccgtctc ttcttttgcc 3279601 agccctacga gcgctccgga taataaaaga aagatatata tacaaatgat tactgttttt 3279661 ttcatcggtc cccaccgttc ctctccgtgc tttgtttcta gccctattat ggacaaggag 3279721 agcctgggat aaacgtgcag ggtgaaaaaa atctagcaag ctgttaatct tatttatggt 3279781 acgatagtgt tttaggaggt ttaagatgaa atacaattat acagtgctgt tatcagcatt 3279841 cacgatgtcc gttctttatt cagtaattta tattcattca tttatcattg ccgctctcat 3279901 cacaatggca ttttattttc tgtttcctta tttgatcttc gcactgccgc ttcaaatcat 3279961 gatgaataaa aagccgaaac gtttcagccc tttgtatctg ctgtattacc ttgccgctgc 3280021 ttttattgcc aacgcgatca ttttcggcat gcttcagcct tcgggacaat ctctgtttca 3280081 aaatacagcc ttttatcttt tcgctgtatt aacagctctt atctattgga tatgggattc 3280141 tgttttactg caaaaaaagg aagcctaaga ggcttccttt tttattaaaa caaaatcgtc 3280201 agtaaataac atagaatgga aggtatcgcc gcaacaaaga aagcggccgc cattttcatg 3280261 cgagatgtac ggccttcttt ggtttctgaa tggtagtttg cccgctgatc gcttccgctt 3280321 acagccaaac ccgatgtaat gatcgcgagc cccactaaaa cgagagacgc aacgccaaaa 3280381 atcgcttcat atgaaagagc ctgcggaaaa atggtgccaa tcatgctctc aatcgcaatg 3280441 agcaggattc ctgctgtcag ggcctttttc atgtttacat cccctttgct ggtgttaaac 3280501 agcttgatcc attcactcgc cagcaagctg cttatttatt tttatgaatc agagcgcata 3280561 tggttctgtc ttttccatta atatctttca gcacttccac ttccgccccc ttaaacgcct 3280621 tgaggatcag gtctttgacc gccgctccct gtttccagcc gatttcaaaa acgacaaata 3280681 ctttatcctt cataacaagc ggaatgtctt ccataaaccg cttataaaat ttcagcccgt 3280741 ctccgccatc ggtgagtgcg tgcagcggct catgaaaacg gacaatttcc gataaatcag 3280801 ccatttcttc ctctgaaata tatggcgggt ttgagacaat gatatccgct ttttttcccg 3280861 ccttaataaa aggctcaagc agatcgccct gataaaagcg cacattcgct ccgagttttt 3280921 ctgcattggc agaggcgact tgcagcgcct ctttcgaaat atcgaccgcc gacacagaaa 3280981 agctttggtt ttcaagcgca agcgtgacgg ctattgcgcc gctccctgta ccaacgtcaa 3281041 caacttcgag cttgccgtct tcagaaaaaa cactccgata tttttcaagc aaatgaaaga 3281101 caacttcttc agtttccggc cgcgggatca gcacatcatc attcaccata aattcccgtc 3281161 cataaaaaaa ctcttttcct ataatgtatt gaaccggcac gccctcttta tgcatctcaa 3281221 cgtgacgctt aaagcgatac agttcgtctt caccaatcgg ttcctgtaag cttgcgagca 3281281 gcttgcttct ctccattccg gtatcataaa gcaataggag ctcggccgca ttttcttctc 3281341 ttcccgcttc ggttaaataa gaagaagccc atttcagggc ttcgaatatc gtcttcatct 3281401 taaccttccg actgctgaag cttgcttgcc tgatcttcaa caatcagcgc ttcaaccact 3281461 tcgtcaagtt ttccttcaag aatctgatca agcttttgaa tcgtcaaacc gattctgtga 3281521 tccgtcacac ggttttgcgg gaagttgtat gtgcggatac gttcagagcg gtcaccagat 3281581 ccgactgctg atttccgtgt ttgatcatat tcagcctggg cttcctgctg aaatttatca 3281641 tagattctgg cacggagaac cttcattgct ttttctttgt tcttaatttg agatttttca 3281701 tcctggcatg atacaacaac acctgtcggc aagtgagtca gacgaaccgc agacattgtt 3281761 gtgttaacgc tttgtccgcc cggtccgctt gaagcaaatg tatcgacacg gatatccttc 3281821 tcatggatgt cgacctctac ctcttctgcc tcaggaagac atgccactgt tgcagtggat 3281881 gtatggatgc gtccgcctga ttctgtttcc ggaacacgct gtacgcggtg ggcgccgttt 3281941 tcatatttga gtttagaata cgcgccgctt cctgtaatca taaagatgat ctctttgtag 3282001 ccgcccgttc cggttacatt cgcttccatg acctctgttt tccagccctg aagctcagca 3282061 taacgggaat acattctgta cagattgccc gcgaataaag cggcttcctc gcctcccgca 3282121 gccccgcgga tctccatgat aacgtttttg tcgtcattag gatctttcgg gatcaggagc 3282181 accttcagcc gttctgacag tgtttccgtt tccttctgaa gttcagaaat ctcttccttc 3282241 accatgtcgc gcatctcagc atccagcttc tcttcaagca tcgcttttgc atcagccagc 3282301 tgttctgacg catctctgta ttgtctatat acgtcaactg tttcttgtat atcagattgc 3282361 tcttttgaat attctcttag ctttttcgga tcgttgacta cttctggatc gctcaaaagc 3282421 tcatttaatt tctcgtatcg ttcttcaatt gattttaaac ggtctaacac ggtcttcacc 3282481 tctgttttcc tgtgcgtaac attctcatta tagtatagtg attaacccca gtcaaaagca 3282541 tttcaatccc agctggaaaa gctccctctg ctatactgga attcgaggag ggatgatgtt 3282601 gctgaaatcc atacatcata ttgcaatcat atgttcagat tacgaaaagt cgaaagcttt 3282661 ctacgtacat aagcttggtt ttcaggtgat tcaagaaacg taccgcgaag agcgcggctc 3282721 ctataagctt gatttgtcgc ttaacggctc gtatgtcatt gagctgttct cgtttcccga 3282781 tccgcccgaa cgacaaaccc ggcctgaagc cgcaggcctg cgccacctcg cctttacagt 3282841 cggcagcttg gataaagctg ttcaagagct tcatgaaaaa ggaatcgaaa cagagccaat 3282901 cagaacagat ccgctgaccg gcaagcgttt caccttcttt tttgatcctg accagcttcc 3282961 attagaactg tatgaacaat aacagttttt gaagaaaaaa aggagatacc cactttcttt 3283021 gccgaatctt ttcttgtttt gtctaacggg aagggaaccg cattctatgg tcgaatacct 3283081 agcttaaaag gaggtatggg atcatgaata caaatatggt agcaagtgaa ctcggcgtct 3283141 ccgcaaagac ggtgcagcgg tgggtgaagc agctgaatct tccggccgaa cgcaatgagc 3283201 tcggacacta ttcgttcacg gcagaagacg tgaaggttct aaaatccgtt caaaaacaaa 3283261 tctctgaagg cacggcgatt caggatattc atctgccgaa aagcgctaaa aagcgcacag 3283321 gcttccttgt ccaaaaaaca agtagcgaca cagaacgaag aatcgagcag cttgaacaaa 3283381 agctggacac ccttttacag caaaggcagg acgaaagcga attgatggca aggatgtcgg 3283441 aactggaacg ccagctgaaa caaaaagccg atgaaggtgt atcttaccag ctgcttcagc 3283501 accgcagaga aatcgatgat attcttgcag atctgcaatc actgacctca caaatgaaag 3283561 aattcaccgc tcattcgatc cccgagactg ctgctgcttc tgaaaaaacc aaaacaagaa 3283621 aaaaaccgct gctgtcactg ttcaaatttc aaacctaaag caaaaagctc ccttaaaggg 3283681 agcttttttt gttacgcagt aagcgcgata atgattggaa gtgaaatcaa tgacagaatc 3283741 gcactgacca caaacgcagt tgcagtttct tcttcttgtt tctcgaaacg agtcgcaatc 3283801 atggctgcaa cggcagaacc agggaatgca acaagaagga ttgcttttgt tgtttggtca 3283861 gctggaagtc cgatagcaag agcaatcagg aacattaacg caggctgaac cgcaactttt 3283921 agtaacgcaa taccgatagc cggcatactg agtttaattt tacgaatacc aacggtaaca 3283981 ccaacagcga agagagcaac accagatgtt gtgcttccaa gctgatcaag cattttaaca 3284041 cccagctcag gaagagtgaa attgaaaacc agcaccaaga tcatactgat taacggagca 3284101 gctgcaagcg gctcacaaag accatgcagg attgattttc ctgtcatctt ccagaagctg 3284161 tcgccactct cttcgttttt cttagaagac tcaccaacag tagcgataat gatcgcgagc 3284221 ggatcaagaa tcgcgttaac cacgatacct gtgaccgcga tcggaatcgc aacttcattc 3284281 gctccgaata agcttcccaa taccgggata cccataaatg cgaatgtcgg ctgtgcagag 3284341 ttcaaagaaa atacagatga gttcgttaaa tcatacttga atataaatct gcaaaccaaa 3284401 agaatgatga tatagaaacc aacaatccca ataattaaag aaatcattaa aggtacttgt 3284461 gataaaaatt cacttctgga agttgtcaaa ataccagcga taaagtgagc tggaagtgcg 3284521 tatttcgtta ctaacgtact tacccctttt gccgacttgg catcataact tccaaaatgt 3284581 cctgcaaacc aacccagcac gataacaaag aagatcggcg ccaggaggat taagatatct 3284641 aagatgctca aaatattctc ctccaaatcc tatgtccgta tactttagct ttacaaaaag 3284701 ctttccctcg gacagaaaaa tttactcgct aattatttcg cgatgacttt tttgtattca 3284761 ggtgtccaca ttgcatcaag taccgcttgt ttcacatctt caggctgacg atttgccacg 3284821 ccgtctttaa ttgctgcttc agcaacggca atcgcaactt ggatagaaac ctcttgaagc 3284881 ttatcaatgc ttggaagcaa tcctgctcca ggtgtttcaa gatcaaccat ttcagcaatc 3284941 gcatcagcag ttgcagcaaa catagcaggt gtaatgatac gcgcttcagc tacaattgaa 3285001 ccaagtccaa gaccagggaa cgcgaatgcg ttgttagatt gtccgatttc ataagaaaca 3285061 ccgttgtatt ctacattgtc aaatgggctt cctgttgcaa taagcacttt tccgtcagtc 3285121 catttgaaca gatcttcagg aacagcttca gcaaggtgag tcgggttaga catcggcatg 3285181 ataaccggac ggtctacgtg agatgccatt tcttttacaa tttcctctgt gaatgcacct 3285241 gaaacccctg aagtaccaat caagattgtt ggtttcgctt gacgaacaac ttcatcgaat 3285301 ggaatttgac ctttttcatc gcgcttccag tctttcactt catccgcatt gcgaaggtaa 3285361 ggtttttgga aatcaaggat gccttcgatg tcttcagtca gcaagcctct gtaatcaagt 3285421 gtgtagaaac gtttgttagc ttcttcttca gataatccgg ctagcaccat tgtgtcacgg 3285481 atttggtcag caataccgat accagcagaa ccagcaccga agataacaac acgctgatct 3285541 ttaatagaag cgccggtttt cttcatagcg gcaagcacac ctgcaagtgt aatcgcgcca 3285601 gtaccttgaa tatcatcatt aaatgtcagg atttcatgat tgtatttttt catgatgttg 3285661 cgtgcatttt tgttgccaag gtcttcccag tgaagaagcg ctttagggaa gaatttcaat 3285721 gcagctttta cataagcgtc aatgaaagct tcgtagcgtt caccttgaac acgttcatgc 3285781 ttgttaccaa tatataaagg atcgtttaga agtttttcgt tgttcgtacc gacatcaagc 3285841 acaaccggga taacacggct agggtcaata ccagctgcag cagtgtagac agccaattta 3285901 ccgattgcaa tattaatacc gcctacaccc cagtcaccga taccgagaat gctttcggag 3285961 tcagtagcaa cgataagatc aatatcgcct gctgtcgcat gaaggttttc aaacgctttt 3286021 tcaataccgt caatgttatc gattgacaag tagattcctt gaggtcttct atattcatgg 3286081 ctgtattcct gaatcgcttc accaactgtt ggcgtgtaca caacaggaag catttcgcga 3286141 agatggtttt tcagcaattt atagaaaaga acttcgttac ggtttgcaag atcacttaag 3286201 taaacatttt gacgaaggcg gtcaggctgc gcttggaatt gctcgtacgc gcgttgtgct 3286261 tgttgatcaa gagaaagtac agttggcggc agaagccctt ctaagccgag ttcttgtctt 3286321 tcttctagtg aaaaagcaac gcctttattt aaagtaggaa tagataaaac ttcttttcct 3286381 ctaagagttg tttctaagtg gccttctttc gtttttttta tgttattcaa gcaaatctcc 3286441 ttctttcttg aaatagttaa ccaagttaag taataaccca tctaaaatat gaccgatcat 3286501 gatctttatg cgactttgtg acaattattc gaacaatgtc tcaaaactat ttacattacg 3286561 taagctattg tatgcctgtc aaaatcaaaa ttcaagagaa gaaaattact taatttttta 3286621 atatacttat ttaaattttt taattgaata ttatcagaat ataaaaaaaa caccggtgtt 3286681 tttagccggt gcattctatc tttataccca tgttttggac tattttttag atttacctgg 3286741 gacttcgtga tgatgtctgc atcttgcttc atatgattca gctgcaccaa ccaaaatgac 3286801 cggatcatcg taagaagcag gtttgccgtc aatgaggcgc tgtgttctgc tcgccggtga 3286861 tccgcaaaca gaacagacgg cttgcagctt tgtcacactt tccgcaatcg ccatgatatt 3286921 cgggacgaca ccgaacggct ctcccctaaa atccatatca aggcctgctg ctatcacacg 3286981 gtagccttta tcggcaagag atgataaaac ctcaacaatt tcctgatcaa aaaactgcac 3287041 ttcatcaacc gcaaccacat ctgtactttc actgatgtga tcccaaatgt ccgcagcaga 3287101 cgaaatggca tagctcgtca tcgatgttcc attatgggag acaacagcag cttcgctgta 3287161 tcggttatca attacaggct taaataccct gacttcctgc ttggcataag ttgctctctt 3287221 cactcttctg atcagctctt cagatttccc cgagaacatg ctgccgcaaa tcagctcaag 3287281 ccacccgctt tgtttcatta tgtacatagg cttcgctccc ctctctctgc cagctgtgtt 3287341 ttagacaata taaaaaacag gcaagactgc tgcttgcctg ttgagaaatc tattattact 3287401 taagaccgta ttttttgtta aagcgatcaa cacgaccatc agcagaagcg aatttttgac 3287461 ggccagtgta gaatgggtgg cattcagagc aaatctcaac gcgtacctct tcttttactg 3287521 agcctgtttc aaattcattt ccgcaagcgc atttaactgt tgcttttttg aaattaggat 3287581 gaattcctgc tttcattgta tccatctcct tccgccctga atcccgtgtg gaaacagagt 3287641 tattatttcg gagcattgtc cgaaacgcat atgagaaaat tatatcagtg atttacttct 3287701 tttgcaaata caatttacct tcttgcagat gatagatttg cctgtttcca ttcttgattg 3287761 agaatatcga aaaattcctg gtttgttttg gtttttttca tttttctcat gaacttttct 3287821 gcgaaatcag gtgaatcaga catcgttttg cggatagacc ataaacgatc aagatgctct 3287881 ttaggcacaa gcagctcttc tttgcgcgtt cctgaacggc ggatatcgat ggcagggaag 3287941 atgcggcgct cggcaagaga gcggtcaaga tggagctcca tgttgcctgt tcccttgaat 3288001 tcttcataaa tgacatcatc catacgtgaa cctgtatcga ccagagccgt agcaaggatg 3288061 gttaagctgc cgccctcttc gatatttctc gcagccccaa agaagcgttt cggacggtgg 3288121 aacgccgctg ggtcaatccc cccggaaagc gttcttccac ttggcggaat cactaagttg 3288181 taggcgcggg caagacgtgt gatgctgtcc atcaggataa tgacgtcttt tttgtgttcc 3288241 acgagacgca tcgcacgttc aagcacaagc tcggccactt tgatatggtt ttccggcact 3288301 tcatcaaacg ttgagctgac gacatcccca gctacagagc gctcgatatc ggttacttcc 3288361 tcaggtcttt cgtcaattaa aagcacgatc agctctgctt caggctggtt cgctgtaatg 3288421 ctgttggcaa tttccttcag caacatcgtt tttccggctt tcggcggcgc aacaatcaat 3288481 ccgcgctgcc caaatccaac cggcgccatc atgtccataa ttcttgtaga caagaagttc 3288541 ggctttgttt caagcaccat ttgacgatcc ggataaagtg gcgtaagagc cgggaaatgc 3288601 acacgctctt ttgcagattc gggatcatcc ccatttactg cttcaacgtg caaaagtcca 3288661 tagtaacgct cattttcttt tggcgggcga accttgccag atactttgtc tccgttccgc 3288721 aaatcgaaac ggcggatttg tgaagctgag atgtaaatgt cttctgagct tggagagtag 3288781 ttgatcggtc tcaggaatcc gaaaccttca gactggatga tctcgagaac gccttccata 3288841 aacagcagat cttcctgttc tgcattcgct ttcagaatgg cgaaaatgag ttcttttttt 3288901 gtcagtttgc tgtaatagga gattttataa tgtcttgcaa gttcataaag ctctttcaat 3288961 ttcatatttt ccaaagagga aatagatacg tctttcataa aaacaccacg cttttcatag 3289021 tcaatatctt actctgaaca tgtcatctgc tgcttttgca caacatccgc caaagcacat 3289081 tcttttttta acataaagga acttctatcg gtaacacttc cacccatgat cggcgctttt 3289141 gttaaaagga ttgtcttaat gagttttgaa ggaagcgagg acaaaaacat gagaagatca 3289201 atacttatat cgtctgtatg cggtagaaat tgaaactttc ctagtgctta aaagaaggta 3289261 ttacgcagta aaattcgcag cactctttat ttttacctta tttcaaaaaa ttattcaact 3289321 gaaataaggt tttgacacgg aattgataga gttgacgctt ttctgcaaaa gttaaagcgg 3289381 gctcacaccc gctttttctg tttgttatgg acggattaca agatttggtt tctttttcaa 3289441 gctgtgtctg ccgtcaacga aacgaacagt gcccgatttt gcacggataa ctaagctttc 3289501 agttgtaccg acagagcctt tgaattgaac tccttttaac agctcgccgt cagtaacccc 3289561 tgtagctgca aaaatcgcgt catcaccctt cacaaggtct tccatgcgaa gcactttgct 3289621 taaatcaagg cccattttgt gacagcgagt gatttcttct tcgctttgcg gaagaagttt 3289681 accaatgatt tctccgccga gtgcttttag cgcaacagcg gaaagcacac cctcaggagc 3289741 gccgcctgat ccgaacagga tatcaacgcc cgtgtggtcg aaagccgtgt tgatggcgcc 3289801 tgcgacatcg ccgtcattga tcaatttgat tctggcgccg gcctcacgaa gctcggaaat 3289861 gatttttgcg tgtctttcac ggtttaaaat tgtggcaacg acgtcctcaa cgtccttgtt 3289921 tttcgctttt gccaccgctt taaggttgtc aatgacaggt gcttcgatgt caatgcagcc 3289981 caccgcttcc ggaccgactg cgattttttg catatacatg tcaggagcat tcagaagcgt 3290041 gccatggtct gcgaccgcga taaccgtcag cgcgttccag ccgccgcttg ctaagatgtt 3290101 tgtgccttca agagggtcaa ctgcgacatc aacgcgaggg ccgtacccgt ttccgagttt 3290161 ttccccgata tacagcattg gcgcttcgtc catttcccct tcaccgatta caacggtccc 3290221 tttcatcggc actgtatcaa aaacgtctct cattgcactt gttgccgctt catcagcctc 3290281 atcttttttt ccccggccca tccatcttgc tgatgccaat gccgcagctt ctgtcacacg 3290341 taccaattcc attgataaac ttctttccat ttcaacacga tctcctctca caagaaacca 3290401 ttatgaattt tgaagctgtt ctatttcttc gtcagtcatt ctttcacgcc aaattgtcgc 3290461 tccaagcccc tcaagcttct tctcaaggct gctgtatcct cggtcaatat gctccagtcc 3290521 cgtaatttcc gtgacgccat cagccatcag tccggctacc accaagcagg ctccggcacg 3290581 cagatcactc gccttcactt ttgcgccttg aagctcgaca ggacctgtga tgatggcaga 3290641 tctgccttct actttcatat tggcacccat tcgtctcagc tcatcaatgt gcttgaatct 3290701 tgccgagtag atggtgtctg tgacgacact cgtccctttc gcccttgtca ggagcgccgt 3290761 catcggctgc tgtaaatcag tcggaaaccc cgggtatacg agggttttga cgtcaaccgg 3290821 ctttaagttc ttctgcccgc cgacaatgag gagctggtcg tcgcttgttt cgatatgata 3290881 gcccatttct ctcagctttg ccgttaacga ctcaagatga gtagggatga cgttatcgat 3290941 aatgacttcc ttgcccattg cagcccctgc aatcataaat gtcccggctt caattctgtc 3291001 cggaatgatc gtatgcttgc agccgtgcag ttccttcacg ccgtcgattc gaatcacatt 3291061 ggtgcccgca cctttgattt tggcgcccat gctggtaagc aatgtcgcga cgtcaatgat 3291121 ctcaggctcc ttggcagcgt tttcgatgat cgttttccct tctgccaaaa cagcggcgag 3291181 cataatgtta atcgttgccc caacgcttac gacatctaaa taaatccgtg cgcctctcag 3291241 cctttcagct cgcaaataaa tggcgccttg ttcattggtt acttcagctc cgagtgcttc 3291301 aaagcctttg atatgctgat caatcggacg gggccctaag tgacagccgc caggcaatcc 3291361 aatgaccgcc tgcttgaagc ggccgagcat cgcccccatt aaataatatg acgcgcgaag 3291421 cttttttact ttcccgttag gaagcggcat gctgatcatc gacgtagggt caacaaccat 3291481 ttccccattc tcaaaatgca cgttgccgcc gatttccttt aacaggtcac gcagcgtttc 3291541 aatatctgaa atctctggaa gcccttcaat tgtcacctcg gaatttgcca aaatggttgc 3291601 aggtattaac gcaacagcgc tgtttttagc gccgctgata tgtactgtac cgtttaacga 3291661 gtcaccgccg gcaatattca acttttccat gatagtctcc ttccataaga agatagctgc 3291721 ggagctaaat aaaatgtcat tttattctgt ctctgcaaat aaagctcatg tccaaaatct 3291781 agccaattcg aagagaaaga atacaacaca ttgtaaaata tcaggaagaa aatagcgaag 3291841 ctttgggggg tacaggtttc aaaagatgca cagagacccg ccggctcgag agacatcgtc 3291901 gtcatccggc aaaagcagta cgcataccct tcattccgat atcagcttct gcagcccaat 3291961 gattccttct ctgtaaagcg gcgtcagcat ctgaagatcc gctgtatcag gtcggtgaaa 3292021 tacaaaggcc gcggcaaaca ggcataaagc tgtttgccgc ccctttcatt atttgttcca 3292081 gtctgccagg aattgttcga ttcctttgtc tgttaacggg tgtttagtga gcgcatgaat 3292141 gactttcagc ggcattgtgc cgatatgagc ccctctaaga gcagcttctg tcacgtgctg 3292201 cggatggcgg attgacgctg caatgatttg cgtgtcaagg ccgtgaatgt caaaaatctg 3292261 tttaacttct gaaatcaggt caagcccgtt gtggccgatg tcatctaaac gtcccaggaa 3292321 tggagataca tatgttgccc ccgctctggc agcaagaagc gcctggttgg cattgaagat 3292381 caatgtaacg tttgttttga tgcctaagtc agtaagtgct cttaccgctt ttaaaccgtc 3292441 agacgtcatt gggattttca ccgtaatgtt cggagcgatc ttcgccagtt cttttccttc 3292501 ctcgatcatt tcctcagctt tcaaagaaat aacctctgcg cttacagacc ctttcacgac 3292561 gtctgtgatc tcgcgaagac ggtcgtggaa tgatacgtta gcttcctttg ctactaaact 3292621 aggattcgtc gttacaccgg cgagaattcc taattcattc gcttctctaa tttcatcgat 3292681 attggctgta tcaacaaaga ataacatttt caaaaagcct ccctgattaa gaaattttct 3292741 gaactgcgaa tatgattgcg ctttctaaag atagacggaa aaccgcctgt caagctgtca 3292801 ggcggctata aaaagttcca attgaattaa gcttggtttg aagaaccaaa ttcacgcatt 3292861 ttaccgataa ctgtttcttt gatcgcttca cgagctggtc caaggtattt acgtggatcg 3292921 tactcgtcag gcttagctgc caatgtttcg cgaacagctt ttgcagaaga aatttggttt 3292981 tcagtattca cgttgatttt agctgtacca agtgaaattg attttttgat gtcagcagtc 3293041 ggaattccag taccgccgtg aagaactagc ggaaggccag ttgattttcc gatctcttcc 3293101 atttctttga agccaaggtt tggctcacct ttgtaagggc cgtgaacaga acctaatgca 3293161 ggtgcaaggc agtcgatgcc agtgcgctca acaagctctt ggcactcttt aggatcagcg 3293221 tagattacgc cttcagcgat aacgtcatct tcttgtccgc ctactgttcc aagctcagct 3293281 tctacagata ctccgtggaa atgagcaagc tcaacaactt tagcagttgt tgctacgttt 3293341 tcttcaaatg gatggtgaga agcgtcgatc attacagatg tgaaacctgc atgaatcgct 3293401 ttcgcacaag attcaaagct tgaaccgtgg tctaagtgaa tcgcaacagg aactgtcact 3293461 ttgtactctt ccataagtgc ttttaccata gcaacgactg ttttgaagcc gcccatgtag 3293521 cgtcccgcac cttcggaaac accaaggatc actggagatt tttcttcttc agctgcttgt 3293581 aaaatcgctt gagtaaactc aaggttgttt aagttaaatt gtcctacagc gtaccctttt 3293641 tctttagctg tattcaacat ttccgtcata gaaactaaag gcatgtcgaa tgtcctcctt 3293701 atgtagcctg attgtcttct agcgaaaaaa gctttccacc ctagcatgac ccatatattg 3293761 ctgtcatatg taaatactca gatcgctttt tctccataac taggatacca acttttcgac 3293821 aaatcggcaa cataatgaca tgattcattt gtttcttctt tttgtcagtt agacttcagg 3293881 ggcagatatt ttttgacggc gtctctgatt tcgtcgatgt caaacggctt ggcaaagtgc 3293941 gtcagagcgc ccaattcctt cgattcctgg atcatgtcga gctctccgta tgccgtcatg 3294001 ataatgaccc ggatgttttc gtcaatgacc ttcatccgtt ttaagatttc gattccgtcc 3294061 atgccgggaa ttttcatgtc caacagcaca aggtcgggcc gttcttttgt cacaatgtca 3294121 agcgcctgca ggccgttcgc agcctgaaac gtctggtagc cttctttatt gaacacttca 3294181 tttagcaaaa tacgaatgcc gtattgatca tcaacgatta aaattttttc attcatcatt 3294241 ttacacccca atattatgat tttcgtcaaa agtaagcagt attgtatgta ttctgtttga 3294301 ttttcctatt tcctttaatt ataatagtct actttacgac attttctgag cattttctct 3294361 tttgttgtat actgatattg tacgttataa aggaggattc acttatgttg aaaatattca 3294421 cgacgcagtt aacaggtatt ttttcccgca ttcaggataa ggaatctgac gcgattgaag 3294481 atggggcgcg gctgcttgct caagcggtga tcagcgggca ttccatttat ttatacggag 3294541 cgaatgagct tcagggcgtc ttttatgagg ccaccgaaag caaagaaccc ttcccatctg 3294601 tcaaagcctt tccagaaaac gctgaggaag tgacagaaag cgacagggtg ctgatgtttt 3294661 gctcagggac gggcacagcc gaagaacagg agctcgcaaa agagctttat gaaaaaggtg 3294721 cgggagtcgt atgcgtatcg cccgcagcca aagacagtgc gggaatagaa cagtattgtg 3294781 atgtgcatat tgattctaaa ttaaaaatgc cgcttgttcc cgatgaagac ggcacccgtt 3294841 acgggtttcc ctctttaatg acagcactgt atgtctatca cgctttatcg tttacactaa 3294901 aagaaattct gcaagagtat gcataatatc ttattgtaca tgctggaact tgccggaaac 3294961 aaataaaaaa gacttgcccg cttttgacaa acggcaagtc ttttttatta cttctgattt 3295021 gcagcttcga cagacgctcc gataaagcct ttgaatagag gctgaggtct tgtcggtctt 3295081 gacttgaact ctgggtggaa ctgagaagcc acgaaccaag ggtggtcttt cagctcgatg 3295141 atttcaacaa ggcgtccatc agggcttgtg cctgagaata cgaagccttg ctcttccatt 3295201 tgctgtctga attcattgtt aaactcatag cggtggcggt ggcgctcgta caccacttca 3295261 tcctgataca cttcaaaggc tttcgtgcct tcttcaagct tacaagggta aaggccgaga 3295321 cgaagcgttc ccccaagatc ctcaacatcc ttttgttcag gaagaagatc aatgatcggg 3295381 tattgagttg acggatcaat ttccgctgag tgagcgcctt ttaagcccaa tacgtttcgt 3295441 gcgtattcaa tagacgccac ctgcatgccc aagcaaatgc ccaagaacgg aatgttgttt 3295501 tcgcgcgcgt attttgtcgc gacgattttc ccttcaacac cgcggtctcc gaatccgccc 3295561 ggcacaatga tgccgtctgt tccgcttgtg agttctgcga tattgttttc tgtcacttct 3295621 tccgcgttga tccacttcac ttttacatct gtgtcaaacg catagcccgc atggcggaga 3295681 gactcgacaa cagaaatgta tgcgtcagga agctcaacgt atttgccgac aaggccgatt 3295741 gtaatcgttt gagacaggtt gctgactttg ttaacaagct ctttccactc ggacatttcc 3295801 gcttctttgc atgccaattt catgtgctcg caaacaagct tatcaagccc ttgtttttga 3295861 agctccagcg gaatggagta aaggttgtcc gcatcttcac attcaataac cgcttttgta 3295921 tcgatgtcgc agaaaagcgc gattttatct ttcatatctt gagaaatcgg catttctgta 3295981 cgaacgacga tgatgtttgg ctgaatgccc aagctgcgca attcttttac gctgtgctgt 3296041 gtcggttttg tttttaattc gccagcagct ttaatgtaag gcacgagcgt acagtggatg 3296101 tacattacgt tttcacggcc gatgtcgctc ttcatttggc ggatcgcttc aaggaatggc 3296161 agtgattcga tgtctccgac agtaccgccg atttctgtaa tgacaacatc tgcgtttgtc 3296221 tctttccctg cgcggtaaac acggtctttc aattcgtttg tgatgtgcgg aatgacctgt 3296281 acggttcctc caaggtaatc tccgcggcgt tcttttttaa gaactgttga atagatttta 3296341 cctgttgtca cgttgctgaa tttattcagg ttaatgtcga taaaacgctc atagtgacca 3296401 aggtccaagt ctgtttcagc gccgtcatcc gttacgaata cttcaccgtg ctggtacggg 3296461 ctcattgttc ccgggtcaac gttgatgtat ggatcgaatt tttgaatcgt cacgttcagt 3296521 ccgcggtttt tcagcaaacg ccctaatgaa gctgctacaa taccctttcc aagtgaggat 3296581 acaactcccc cggttacaaa aatatatttc gtcatttcgt ttgctcctct cttcgctctt 3296641 agctacattt ttaaaatgta ctattttata aaaaatcatt tagcctttta aatgatttat 3296701 aagaaaaatg aggggtgaaa ataagaaagc tccctttcaa tttcttgaaa gggagcataa 3296761 cgtactatgt tctctcttcg tttttgaaga gcccaaaata catactacat agttcgacta 3296821 tgaaagtcaa gatcgttttg aagatgaaat ctgatactat ttaatttcct cttcttcatc 3296881 atcatagtct tcatcatctt catcaataat atcttcttcg atctcaagat catcgtcgtc 3296941 ttcatcaaga tcttcttcgt caaaatcgtc ggcttcaaga tcgagttctt cctcaacttc 3297001 atccaaatca aggtcgtctt cgtcgatctc ttcaaactcg tcaagatcaa gatcttcttc 3297061 gactgctttc ttcgcttttt tctttttcgc cttgactgtc ggctgagttt cttcatcaag 3297121 ctgatcataa ggataccagc tgcgaagccc ccacgtctgg tcagaaagcg ccaggaagcg 3297181 gccgtcaatg tttaaatctg tataaaattg agcaatgcgg tctccaagct cttctttttt 3297241 cacgccgagc aaagatgcga tttcatttaa aagctcctga aaaggaactg gttttttatg 3297301 ttcttcaaat aattcgtgag cgatttcaac taaagccatt tcctttagct cttcctgtga 3297361 atattgtttg atacccaagg tcggacactc cctttctatt acttatatgt atctgtttta 3297421 tcaataatga aagcgatttt gtatcgttct tatacaaacc atacctctca ttataaacaa 3297481 aataaaacag aatatgctac ccttaacagc gttaatttaa ataattttac aagagtgatc 3297541 cgactgagag atgttttccg ttaatccgcg agcattctgg agatgaccag tctttgaatt 3297601 tcttgagtgc cttcatagat ttgcgtgatt tttgcatcac gcatatagcg ttctaccgga 3297661 taatcttttg tatagccgta gccgccgaaa atctgcacgg cttcggtcgt taccttcatc 3297721 gccgtatccc cagccatcag tttggacatg gcggaagctt ttccatatgg aaggcccgat 3297781 gattctaacc atgcagcctg ataggtcagt agccttgaag cttctatcat tgtcgccata 3297841 tccgcgagtt taaaagcgat gccctgctgc tcggcgatcg attttccgaa ttgctttcgc 3297901 tcttttgcat attgaagcgc cgcatcaagc gctccttggg cgatgcctac agcttgtgca 3297961 gctatgccgt ttctgcctcc gtcaagcgtc ttcatcgcga ttttgaagcc ttctccttct 3298021 tctccgagac gctttgatgc gggcactaca caatcttcga acatgatttc cgttgtcggt 3298081 gaagaacgga tgcccagctt cttttctttc ttgcctgtaa aaaatccttc aaaatccttt 3298141 tctactataa aagcggtaac gccttttttc tttttctcgg gatcggtgac ggcaaaaaca 3298201 atgtaaatat cagcaacgcc gccgtttgtg ataaacactt tggaaccatt taacacatag 3298261 tcatcgccga ttcgttcagc agttgttttc atgctgccgg cgtcagagcc agaccctgct 3298321 tcggtcaaag cgaatgcgcc gattttctct ccgagagcca gctgtgttaa gtactctgtc 3298381 ttctgttcct ctgtcccaaa ggcaaacagc ggccagctgc aaagagagat atgggcggaa 3298441 agcgtcacac cggtggaggc gcacactttt gacagctctt ccaccgcgat gacgtaggct 3298501 aaatagtcac ttccaattcc gccgtaatct tcaggccatg gaattcccgt caggcccaga 3298561 tttgccattt cccgaaacag ctcgcgatcg aagcgttctt gttcgtcccg ttcagccgct 3298621 gtcggggcca cctcatgctt cgcaaaatcg cgcaccaatt ttcgtatcat ctcatgttct 3298681 tctgataatg aaaaattcat tgcttctccc ccattttcag atcagcgcct aaaacggatt 3298741 gagccagaag ctcgacgacg tcgtacgttt tgacttggtc ttcggcttcc ttcgcctttg 3298801 tgccgtcccc aagcatcgtg agacaatacg gacagccaga actgatcacc gatgggttga 3298861 ctgcgagcgc ttgctctgtc ctggcgacgt taatcctgtt gcctgtttct tcctccatcc 3298921 acattaatcc cccgccggct ccgcagcaca tgccggtttc ccggcttctc tccatttcaa 3298981 caagctgcac gcccggaatg gctttcaaaa tctctctcgg cggatcatag acttcattgt 3299041 accggcccaa atagcacgaa tcatggaagg taatcgtctc atgaagcggg tgctgcggtc 3299101 ttaattttcc gtttttcaca agctcggcca gcacttctgt atgatgataa acctcgcctt 3299161 caaatccgaa atccggatat tcgtttttaa ataaattgta tgcatgggga tcgatcgtaa 3299221 cgattttttt gacatcattt ttttcaaatt cagaaatatt cttctcagcc agctcttgga 3299281 acaaaaattc atttccgagg cggcgcggcg tgtctcctga atttttttct ttattgccga 3299341 gaatcgcgaa ggacacgccc gcgtgattga gcagcttggc aaaggaaatt gcgattttct 3299401 ggcttctgtt gtcgtaagac cccatggagc ctacccagaa aaggtactca aattcttttc 3299461 cttctttttt catttctttt acagtcggaa tctcagcatc cggcgcctcg tcacgccaat 3299521 tttcacgttc cttgcggttg agtccccacg gattcccttg ccgctcaata cttgtcattg 3299581 cgcgctgggc gtcactgtcc atttttcctt ctgtcagtac gaggtagcgg cggaggtcga 3299641 tgattttatc cacgtgctca ttcatgaccg ggcattgatc ctcacagttc cggcaagtgg 3299701 tgcatgccca aatttcttcc tctgtgatga cgtcgccgat caagcttgga ttgtaatcaa 3299761 gcgccgctgc ggcttcctgc gatccgctgc ccgctgacgc cgcagccagc tgattgcctc 3299821 tcgtatgccg aaacgctgct gcgggcaccc atggggagcg cgaggtgacg gcagcgcctt 3299881 tttccgtgag atggtctctg agacgcaaaa tcaagtccat cggagaaagc atttttccgg 3299941 tgcctgttgc aggacacata ttggtacagc ggccgcactc gacacacgcg tatagatcaa 3300001 gcagctgaga ctgtctgaaa tcctcaattt ttcccgctcc gtagctttct ttcgtttcgt 3300061 cggtaaaatc aattttttca agttttccgg cagattccat tcgattgaaa aagacgtttg 3300121 ccgggccggc gattaaatgg gcatgctttg actgaggcac gtacactaaa aagctaagca 3300181 agaataggag atggatccac catgcgatat agaaaatcac cgccgcgcct gttttcccga 3300241 caccgctaag cataaacgca atacctgagg caattggctc gctccaagaa agcccatgct 3300301 catgccaaat cagattcatc ccgttcccaa gcagaacggt cagcattaat cctccgataa 3300361 aaatgagaac gagtccggct ttgaaaccgc gtttcagcct cacgagcttt tcgatataac 3300421 gtctgtagaa tgcccaccca acagcaatta aaatgagaaa cgtaacaatt tcctgaaaaa 3300481 aggtgaaggc gggatagacc gggccaagcg acagattccg gccgggagcc agtcctttga 3300541 tgataaagtc aattgctccg aactgaacca atataaatcc gtagaaaaac atgacgtgaa 3300601 tgattccgct tttcttgtcc ttgagcagtt ttttctgtcc gaatacattc acccatatgg 3300661 cgtgaagccg ttccttgaac cgttgatcaa attgttcttt ctggccgagc ttgatgtagg 3300721 ccagtctcgt tttgaccaag taaacaaaca aatagacagc gtaagcggtt acaatcagaa 3300781 ataataatgc atttgcgatg agaaagccgc tcattccaat tccccctttt tactgataaa 3300841 gaccgcgatc ccctaccccc gaatctgtat aagattatct ttatgataaa taatgaatga 3300901 gtgttcagtc aataattaaa ttcctgctgt tcgggcacac tacctttact acggaaagga 3300961 gtgccggtat gaaggtattt atcgtgatta tgatcattgt cgttattttc tttgccttga 3301021 ttctgcttga tatcttcatg ggccgtgccg gatacagaaa aaaggcgtac gagcctgttt 3301081 tttcaaaaaa gaagagtgac atcgaattga tccactgcgg cgctgatctc gttgagcgga 3301141 tgatgaatga tattcgccag gccgcctctt ctgttcacat gatgtttttt attatgaaaa 3301201 atgatgaggt cagccacaat atgtatacct tgctgaaaac aaaagcccaa gctggcgtat 3301261 ccgtttattt gcttctggat tgggcgggct gccgggcaat taaaaaaacg gcgcttcaga 3301321 cgatgaaaaa tgccggcgtc catgtccatg tgatgaatcg tccccgtttt ccttttttct 3301381 tttttcacat gcaaaaacgg aatcaccgga agattacggt gatagacgga aaaatcggtt 3301441 atatcggcgg gtttaatatc gccgaagaat atcttggaaa gaaggcgaag ttcggcaatt 3301501 gggaggatta tcatctgcgc atgatcggag aaggcgtaca tgatcttcaa acgctttttg 3301561 cttctgatct aaaacgaaat accggaatcg aactgggttc ggatgtttgg ccaaagcttc 3301621 agcaagggac tatttctcac aagatctatg cgaccgacgg ttattccctt gaaaacatat 3301681 acttggccaa cattgcccaa gcgaagaatc gccttacggt ttgcacgcct tattacattc 3301741 catcaaaacc gcttcaagag gcccttatta acgcaagaaa aaacggcgta tccgtgagaa 3301801 tcattgtacc gatgaaatca gaccatccgc tggtacgaga agcggctttt acgtattatt 3301861 cggagctctt ggatgccggc tgtcttattt atcgttatta tcaagggttt tatcatgtaa 3301921 aagccctcat catagacgac catctcagca ttatcggaac agccaacttc gataaacgga 3301981 gcctgttctt aaatgaagag gtgaatgttg aaattgatga cgaagcgttt acaagtgaag 3302041 tctatgccac aattgaggag gatatgaaaa agtcggagct gctgacgatg gaggatttca 3302101 gcaagcgcac attcaggcag cgcccggcgg aatggctcgg cagggcatta tcttatttct 3302161 tataaaggag agttcctatg attttcagat tcgggttcgt ttcaaatgcg atgagccttt 3302221 gggatgcgtc tcccgctaaa acattgacat tcgcgcgtta ttcaaagctt tcaaagactg 3302281 aaagaaaaga agcgcttctg actgtgacaa aagccaattt gcgcaatacg atgagaaccc 3302341 ttcactatat catcggccac ggcattcctt tgtaccgttt ttccagttcg attgtgccgc 3302401 tggctacgca tcccgacgtg atgtgggatt ttgtaacacc gtttcaaaaa gagtttcggg 3302461 agattggaga gcttgttaaa acccatcaac tgcgaacaag ctttcatcca aatcaattca 3302521 ctctgtttac gagcccgaag gaatccgtca caaaaaatgc ggtaacagat atggcgtatc 3302581 actaccgcat gcttgaggcc atgggcattg ctgatcgctc cgttatcaac attcatattg 3302641 gcggcgctta cggaaataaa gacaccgcca ctgcacaatt tcatcaaaat ataaaacagc 3302701 tgccgcagga gatcaaagag cggatgacac ttgaaaatga tgataaaaca tatacaacgg 3302761 aagaaacgct tcaggtctgt gagcaggagg atgttccgtt tgtctttgac tttcatcatt 3302821 tttacgccaa tccagacgat cacgccgacc tgaatgtagc actgccccgc atgatcaaaa 3302881 cgtgggagcg gatcggcctt cagccaaagg ttcacttgtc ttccccaaaa tcggagcaag 3302941 cgatacgcag ccacgccgat tatgttgacg ccaacttttt gctgccactg ttggaacgct 3303001 ttaggcaatg gggaactaat attgatttca tgattgaagc aaagcagaaa gacaaggcgc 3303061 ttctccgctt gatggatgaa ttaagctcca tccgcggtgt caaacgcatc gggggcggtg 3303121 cgctgcaatg gaagtcataa atgtgcaaaa ataggtttac gacttgtcag ctttgggaac 3303181 ttaggctata taagacaaca atcgatggag gagaaagatc atgaaaaata tcaagtctct 3303241 gaaagtagcc gcacaggcct ttactttaag aaatttgatt catctttata aaatgtgcca 3303301 ttccggaagc cacgaggttt atatttattc aaagaaaacg atgtgcaaaa tcaaaagctt 3303361 aattgagctt gaaacgttcc gcatggctca taatgaaaag gaatatctga tcgtagttga 3303421 aggaacaaaa gcatcacagc tcattgaaaa attccaaaat ctcatcgagc ctgctgagag 3303481 agaagcgctc taacttacat acaaaaaagg atagacatct gtctatcctt tttcttatgc 3303541 tcttacataa tggagctgaa ccgcttgtcc aaattgtttt gtccctttta accgcagttt 3303601 tgtttcattt gttagttcgt gaaacagcgg gatgccgctt cctaaaacga cgggaataac 3303661 agtgatgatg aattcgtcga tggcatcttc tttcataaag tcattcacaa gctctgcccc 3303721 gccagctatc cagatgtttg agcctttttc ctgtttcaaa cgggcagtga aggctctggc 3303781 tccctcattg ataaacgtca catgttcatc ttgataactg tcgggcgatc ctgtaaaaac 3303841 atagcaggtt ttatcctgat acgggaaaac cggtgttagc actttaacgt gctcatatgt 3303901 gctccgccct aaaatgactg tatcaacagt ctgataaaaa tcactgtagc cgttgtcacc 3303961 ttcaccttca aattcatcca gccaatcgat gcttccatct tcttttgcga tcatcccgtc 3304021 caatgaaaca gcaatgtaca gcacagtttt tctttccatg ttctcctcct atcgatgcac 3304081 catttgcccg aattgcgctt gatgcagcct gctgtatagg cctccggctt cgatcaggtc 3304141 ttgatgacgg ccttgttctt caataccgtt gtttgtgacg actacaattc tgtccgcgtc 3304201 tttgattgtt gccagcctgt gggcgatgac aagcgtcgtg cgcccctcag acaactcttg 3304261 aagcgccttt tggatcgccg cttccgtctc tgtatcaagg gctgaggtgg cttcgtcgag 3304321 aatcaagatc gacggatttt tcaagaacat ccttgcaatt gacagacgct gtttttgccc 3304381 gccggaaagc ttcacgccgc gttcgccaat catagtatcc aacccatcgg gcatgttatg 3304441 gacgagctct tccagatgcg cctgcttcac agcttgccaa atgtcttctt ctgatgcgcc 3304501 tagtcggccg taggcgatat tttctctaag cgtgcccgag aataagaaaa cgtcctgctg 3304561 cacgacgcca atctgcccgc gcaacgaaga aagcgtcatg tcttttatac tgatgccgtc 3304621 aatcgtaatg tcgccctccg atgcttcata aaaacgcgga agcagactgc aaagcgttga 3304681 tttcccagca cctgacggac cgacgaacgc caccgtttcc cccgcttgaa tggataggtt 3304741 gatgtcattg aggacattgt gatggtcatc atagccaaac gaaacatgtt tatagcggat 3304801 attgcccttc aggccggaaa catctttcga atcaggtgag tcctgaatat ccggctctgt 3304861 ctccatgagc tccatatagc ttttgaaacc cgcgatcccc ctcggataca tttcgataat 3304921 ggcattaatt ttgtcaatag gcctgaacag cacattcgtc aagagtacaa acgccacaaa 3304981 ttccccgtac gataaggagc cgcgaatgac aaaccacgtc ccgcacaaaa ggacaaacag 3305041 cgtgacaaac cgggtcagca tatagctgat tgaaccgttt ttcgccatga ttttgtagga 3305101 agaaagcttt gtgacacgaa aacgctggtt gttgacggcg aagcgttctt tttcaaatgc 3305161 ttcatttccg aacgcctgca caagccggat gccgccgatg ttattttcta cacgcgcgct 3305221 gaagtctccg atatccttgt tcagcgtggt aaatgctttg gtcatttttt tgttgaaata 3305281 aagcgctagc caaatgacga tcggcataat gataaacgtt aataaagcaa gctgccagtt 3305341 aataaacagc atcactccga acgccccgag aatggtcatg accgcaatga ataagtcttc 3305401 cggtccgtga tgggcgactt caccgatata cattaaatcg ttcgtgagct tcgacatcag 3305461 cgttcccgtc ttgttgttgt cgtaaaattt gaacgagagc ttttgcaaat ggtcaaaaag 3305521 cgactttctc atatcagtct caatattgat accaagcatg tgtccccagt aggtcacgat 3305581 atactgaaga gccgagctga gcgcgtacac cgcaaataac ccgattgagg tcgcgatgat 3305641 cagtccccag tccctgcccg gcagcaaggt atcaataaaa taattgacga tcaaaggaaa 3305701 actcagctcc attaaacctc ccgcgatcgc tgagaaaaag tcgagaaaga acaacgtttt 3305761 atatggttta taatatgaaa aaaattgccg cagcacccta tcttccccca atgtataaat 3305821 aactgataat atttctcaat tatactatac acgggctgtt ttgtaagatc agatttcttt 3305881 tttcttacag aacacctgaa aacaggcggg caaacgactc ttttgtccgg tcagccacac 3305941 ctcttttata aaagccgaca gggctgagct tttcactttc ctgcatatcc tcttcaaaat 3306001 gggcctcaag ggttcggatc gcttcggcat ccgtgaagaa cacattcact tcaaagttga 3306061 gctgaaagct gcgcatgtcc atattcgcgg taccgacgga ggcgagatcg ccatcaatga 3306121 tcatgacttt ttgatgcatg aagccttttt ggtaggagta cacttcaatg ccctcaagga 3306181 gcagctccgg gaaataggac ctcgacgcgt attgggtcaa aaagctgtcg ttcttctccg 3306241 gcaccataac ccttacctct accccctttg tcgccgctgc ttttagcgcc gtgcgaatgg 3306301 attcattggg gacaaaatag ggcgtggcga tccatattga tttctgcgct gaagaaatca 3306361 tttcataata aaggtcgctc atgctttcct tcatgtcagg gcctgtcgcg acaatttgat 3306421 aaatgcctcc tccttccacg ggaaccgggg tattgtactc ctcttgatca attagcactt 3306481 cattggagac atattcccaa tccagcataa agatagcgtg gagcgtttgc acaatttccc 3306541 cctcaagccg caggtgtgta tctctccaaa atccgatgta cggatctctg ctgatatatt 3306601 ccttcccgac atttaatcca cccacaaaac cggttttccc atcgatgatc acgattttcc 3306661 ggtgatttct gaaattcagc ttctggttga aaaacccgta tttcagcgga gaaaacggga 3306721 cgatgtccac ccccgcttgt ttcattctca taatatctct tcttgccagc ttcatgcttc 3306781 ctgccgcatc gtataaaaac ctcacctcga caccctggcg cgctttctcc atcataatat 3306841 ccatcatgcc gcgtccgagc atgtctgatt taaacatgta gtattcaata tgtatgtaag 3306901 attccgcttt tctcattgct ttgaaaatgt ccgggaaggt ttcttcgccg tttttcagca 3306961 ctttgatgtt gcttttcgta ttgatattca tatgggcagc cctgatggaa tatgtaaaga 3307021 acctctcttg attgtccttc agccctgtca cttcgggcgt ttcctccttg tcaaacagct 3307081 tcctgagctt ttccctgttg tacattcgtt ttgtcttaaa cagctttccc tttacataaa 3307141 gctgtcccga aaacagataa aacacgtagc cgacgattgg aaaaaagaca agaatatgga 3307201 tccatagcag cgtgtgctgc gaggtgcggt tttcaagaat taatgaatag atgctgaaca 3307261 aaataatgct tatatagcaa agcaatcctc cgtaaaactc aagtctggaa accggaaaaa 3307321 accaaatgac atatgccccg atgagcatca tatataaaaa gaaaaattcc agtctccttt 3307381 tcagcatcct gattctctcc aatctgattc aattacctct gtattacctc ttttttctaa 3307441 tcgataaacc ttgtaagtaa aaaacctctc cgccaaagga ggagaggttt agagaaaact 3307501 aactgtcacg gaattcatcc gcatcgtttc tgcagaaata aagcaagact attggcaacg 3307561 ccgagtgaca acatgagcgg caagctgaac ccgctcagca ctccggcaag cgccgaaaag 3307621 aaggcggcgc tgtgactgca aatacggtgg atagagtaaa tttgataccc attctgatga 3307681 gagaaaatat ataaaacggg aaattgatca gaaagatata aggagttagt caggctgaat 3307741 cataatctgg ctgttccgcc ggtttaaaat gagtaaaatc cttgatgtta tttccatata 3307801 caaacataac aggattcccg gcagcccagc cattaccttg gcagaaaaaa ccccctcttg 3307861 caagggggat tttcacgagc gtttccgata tacaacgtag ctgcgggtca gatacttgag 3307921 cggcagactg aacacatgaa ccaatctcgt aaacggccac aggataaaaa cgacgtatcc 3307981 tatcacaata tgaaacttaa accatagcgg gacactctcc atcaaagagg cgtcaggcct 3308041 gaacaaaacg atttccctga accagggccc gactgtggtc cggtaatcaa atcctttcga 3308101 atcaatgttg agaaacgtgg ccgcaacgcc tgacagcatc atgaacagca gcaggaggag 3308161 cgtaaggata tcggatggcg agctcgtttt gcggattctt ttgtcaaaca gccttctgta 3308221 cgtcaggatg acaagtccgg tacatgccgc aatgcccgcc ggcaagccag cgccaatcgc 3308281 cattttgtga tacatatgct ctgaaatgcc aagggaagca tacacgcctt ctgggatcag 3308341 aatccccatg acatgcccgc cgacaacgca cagcagtccc cagtgaaaaa gtgtgctgcc 3308401 agccgcaagt tttttctttt ctaacagctc gcttgatttc gccgtccagc caaattggtc 3308461 atgctgatag cggtaaatat ggccgccgat aaagattgtc aatacaatgt atggcataat 3308521 accccagagg atctgcccgc tcatgcctga acagcccctt caacgctttc acgtacgcca 3308581 atgttttcaa gcgcggccag cagcacgtgc agcagttcag cgtatatact gtcatttttt 3308641 tcgagacggg atgccagctc cctcacattg gacagatatt tctcaaacac gcttctcgct 3308701 gcttcaattt ctgcagccgc agcaaattcc agcatcagcg gcagataatc aggcagctct 3308761 ttctctgtcg gcaggaaacc ggattgctcg tatgtgtttt ttaaatgcag caattcaatg 3308821 ccgcgttccc tttgctcgcc tgagttaaag taggtgacat acatatttgt ttttttcccg 3308881 aagtcgaatg tatagacata gtgttcaatc agcgcttccg gagaatagct ggctgacgtc 3308941 tcgaaaaagt gcagcagctt ctcccggatt tgccggttgc cgatttcttg gataagagcc 3309001 ttccaatcgg gaagctcggc tctccactct tcatccggat aagagagaag acaggaaaga 3309061 gcagagaacg tgatttgccg gtctgtggtg ttcatcttgt tacacctcat ttatcaaaag 3309121 ttagaaacag gagccggggc cgcctgaaaa tgataagccg cagcttcctt gttcagcgta 3309181 taaatctgat acttcttctc gatggctgct cggaatcaca aagcggtcat catatttggc 3309241 aatcgcaagc agccgataca tatcttcaat ttgctgttct gttaagccga cactggagat 3309301 cagttccgga tcgattgatt tattcgtctg gaccgctctc atatactggc gcatgacaga 3309361 cattttcttt aatgttgacc gaatatgatc cgtatcaccg gctgttaaca gctgcgccaa 3309421 ataatctatc gggattctca tttggtcgat agccggaaaa atatcttccg ccgtttgccg 3309481 gctgcctttt ccttcaaaga gattcataat cgggctgagc ggcggaatgt accacaccat 3309541 tggcagcgtg cggtactcag gatgaagcgg cagcgcgatc ttccagtcaa tgatcatttt 3309601 atagatcggt gattgctgcg cggcctctat ccattcagcc ggaatgcctt gttcttttgc 3309661 cagtttggca acctcaggat cattcggatc aagaaaaacg tccaattggg aatggtagag 3309721 atccttttca ttttcaacag atgccgcttc ctccactttg tccgcgtcat atagcatgac 3309781 gccgaggtag cggattctgc caacacacgt ctcagagcag atggttggca gtcccgcctc 3309841 caaacgcgga aagcagagtg tgcatttttc cgctttgttc gtttgccagt taaaatagac 3309901 ttttttataa ggacaggatg agacgcaata tctccatgaa cggcatgcgt tttgatccac 3309961 aagcacaatg ccgtcctcct cgcgtttgta catggcgccg gatggacagg atgagacgca 3310021 tgccgggttg atgcagtgct cgcaaatacg gggcaaatac atcataaaga cgtcatcgaa 3310081 ttctgttttg atcgattcct ccatcttttg tacgttggga tcttcaagtc ccgtaatgtg 3310141 gccgcctgcg agatcgtcct cccagttcgg tccccattcg atattcatga aatcccccgt 3310201 caaggacgat ttcgggcgtg ctaccggctg gtgttttttc tgcgggctgt tcgttaatgt 3310261 ttcataatca tagttccaag gttcatagta atcatcaatt gacggctgat tcggattata 3310321 gaaaaggcct gcaagccgat tggttttcga gcccgatttc agctcgagct ttcctttttt 3310381 caatgtccag ccgcctttat atttgtcctg gtcctcccat tgcttcgggt agccgatgcc 3310441 cggctttgtt tctacattat tgaagtacat atattccgca ccggaacggt ttgtccacgt 3310501 gtttttgcag gtgacgctgc acgtgtggca gccgatgcat ttatccaagt tcatgaccat 3310561 accgatttgc gctttaatct tcaagccaat cgacctcctt cagcttgcgg atgacgacgt 3310621 tcaggtcgcg ctgattcccc gttggaccgt aataattaaa gccgtagctg agctgggcgt 3310681 agccaccgat catctgtgtc ggcttgacgt gaatccttgt cgggctgtta tgggtgcctc 3310741 cgcggttatt cgtcagcttt gtgccgggca cgttgatgtg gcggtcctgg gcatggtgca 3310801 taaacgccat tcctttagga atccgatgag acaaaacggc tctcgcgacg acaacgccgt 3310861 ttcggttgaa gcattcaatc caatcgttgt ctttgatatc cgtgtcctct gcatcatctt 3310921 tattcatcca cacggtcggc ccgccgcgga acagcgtcag catcggcaga gaatcaaaat 3310981 acatgctgtg gacagaccat ttattatgcg gcgtcaaata attgaggacg atttcttttc 3311041 cctcttgatc aggccgtttg ctcagaaacg ggcgatgctg gaggatcggt ttgaatgtcg 3311101 ccatcgtttc accgaattcc atcatcagtt catgatcgac ataataggat tgtctgcctg 3311161 tcagcgtccg ccacggaatt aatttttcaa cattcgttgt aaacggcgaa tacctgcgcc 3311221 ctcctttttc agagccggta aacgctggag acgtgatcac cgttttcggc tgggctgtaa 3311281 tttgttcgaa cgtaaagcat tcttcctcgc gttcttccgc caggtctttc agcttcaggt 3311341 tcgtgatgtt ttcaagtgat tcccatgctt ttactgcgac ctttccattc gaagtggatg 3311401 atagggttaa aatcgcttct gcagcctgct ttgcttcact tatatttgga catccctttg 3311461 ccacgctgtc cgaggtgatt tctcccagtc tctgtttgag tgattcatat tcatcggcta 3311521 ttgaccagct catccctttt gttccgctcg gctttaaagc aacgttcgga ccaagtgcag 3311581 tcattttatg aaaaatgtgt ttgtaatccc gttcaacgac ttggatgttc ggcatcgttt 3311641 ttcccggaat ggcttcacat tcgcctttgc tccagtcatt gattttgccg aatggctggg 3311701 ccaattcctg catggtgtcg tggagcagcg gtgtcgcaac cacttctttc accggctcca 3311761 tatcgacttc ttctgccaga tcggaaacgg cttttgacag cgccttgaaa atatcccagt 3311821 ctgacttcga ttcccacgga gccgagatcg caggagcaaa tggatgaatg aacggatgca 3311881 tatctgtgct gctgagatcg tgtttttcat accatgtcgc cgccggcagc acgatatcgg 3311941 aatacagcgc cgtacccgcc attcgaaaat caagattgat taataagtcg agctttcctt 3312001 ccggcgcctg ctcccgccat ttgatttctt ctgggcggat gctgtcgctg tcgtcattca 3312061 ttaaaccgtt cgttgtcccc agcaaatgct tgagaaaata ttcatgccct tttcctgagc 3312121 ttgagatcag atttgcccgc catacaaaga gattccttgg gaaattcact tcattgtcag 3312181 gatcttcaat cgcgaatttc agttttttct cttggagctg tgaggccacg tacgcaccta 3312241 cgtcttcagg tgttgctgcc cctgcttttt cagcttcttt atacagatcg atgccatttt 3312301 gattgaaagt cgggtaagac ggaagccacc ctagccgcgc cgccagcaca ttgtaatcag 3312361 cgtggtgctt gtagcgggat gaagcagcaa tcggtgatgc caaatcactg atcggctggt 3312421 cctcataacg ccactgatct gtcgcaaagt agaaaaatga ggtgccattt tgcagcttgg 3312481 gcacgccttc ccagtccttt gcagttgcaa tcgtctgcca cccttcagca ggtcggagct 3312541 tttcctgccc cacgtaatgg gcccagcctc cgccgtttac gccttgggcg cctacaagta 3312601 aaacaagatt taacactgct cggtagatcg tgtcggagtt gaaccagtgg ttaatgccgg 3312661 cccctacgat aatcatggac cggccgtctg tatcgatcgc attttgggca aactctctgg 3312721 caatcttaac gacagcttct tttttgattc ctgtcatttg ttcctgccag gcaggcgtaa 3312781 acggctcagg gtcatcatag gagacagccg atcgttcgcc gatgccccgg ttcacgccgt 3312841 agttagccag tatcaagtca aacacggtcg tgatgtacgt ttcttcaccg ttcaggttca 3312901 tttttttaat aggaagatcc cgctcgagca ctttgtttcc gtcatttgaa aaatacggga 3312961 tgcgcaccgt gccgatttcg tcctctattc ccagcacaga gagacggggt tcaatcggtt 3313021 ccccggtttc ttcatcaatc atgtgcaggt tccatttctg ctgcccgtcc cagcgcgagc 3313081 ccattgtccc ttggggtatg gcaaatgaac ttgtctgttc atcccaaacc gcaggcttcc 3313141 actgatcatg ctttgtcttc cgcccgatgt ccttcgcatg cagaaaccgt cccgctgtgt 3313201 atacgccatt ttcttttgac agagtgacga gaaatggaaa atcagtgtat tgcttcgcgt 3313261 actcaataaa acgttcagtt tcttggttca cgtaaaattc ctgcagaata acgtgaccca 3313321 tcgccatcgc aagcgccccg tcagtccctt ggcgaatact cagccagtca tccgcgaact 3313381 ttgaggattc cgcaaaatct ggactgatcg aaatgacctt agcgccttta tagcgggcct 3313441 ccgccaaaaa atgcgcgtca ggcgttctcg ttaacggaac gttggagccc catgtgataa 3313501 tatagccgga attgtaccaa tcactgcttt ccggaacgtc cgtctggtca ccccaaattt 3313561 gcggggatgc tggaggaaga tccgcatacc agtcataaaa actgagcata gggcctccga 3313621 ttaacgacat aaaccgggag cctgatgcgt ggctgatcat ggacatggcc ggaatcggag 3313681 aaaaaccgac gtttcggtca ggcccgtatt tcatcactgt atacagcaga gaggctgaaa 3313741 tcagcttcag cacctccggc cattcagcgc gcacaaaacc gcctttccct ctcgcctgtt 3313801 tataggactt cgctttttca gggttttcga cgatcgattt ccaggcttcc aatggatttt 3313861 gatgcgtctg caatgcctcc cgccacaaat tgatcagcac accgcgcacg tatggatatt 3313921 tcacacggag cgggctgtag atataccatg aaaaactggc cccccgcggg cagcctctcg 3313981 gttcaaaatc aggcatatcc gggcctgttg atggataatt caaattttgc ccttcccacg 3314041 tgactattcc gtttttcaca taaatattcc agctgcaaga ccctgtacag ttgacgccgt 3314101 gggtggagcg aacgactttg tcgtactgcc atctgtttct gtatacattc tcccaatcgc 3314161 gatcctcgcg ggtagtttgg ctatgtttat ttgaatggtg ttcgatagga gagaaataat 3314221 tcaatctcct aaacaacgga ctccttttct ttttcttcat gagagttcac tccttccgag 3314281 tcaggtgatg ctaagttcac tataaacaga gacagcgtgt ttccttgtga actatgtcac 3314341 acactctgct tttttcacaa aatgttcaca caaaggagaa ggaaggctgc gttcaggcag 3314401 gacgcttggg tcattagctg cctttcattc aaagatcaaa aaaaaccggc tctatttaag 3314461 aaccgggctc agcgttttca tcctgtgatg tatgcagata ccgcaaaaat aattgatagg 3314521 aacaaaaaac attttgctga agcatagcca aaaagttcat ttgcagctgc ggatgataag 3314581 acatcatttt cttaaatatg taatatggga tgttgagaat cagaatgtct gaagtggcat 3314641 tgactgagat aaagggcgat aaataaagcc cgcctttttc atcaatcgga aacacatcgc 3314701 ctttttccca cagcgcaacg gttttcgacc cttcagggag ccttgtgtcc ataaaacgga 3314761 cactgccttt taatacaata taaacagatt gagaatgaag aaaagatgga gactgatcac 3314821 atgaaccgcg gataaacgtg ccgtttttca gcaaggtttc gacaatggat agaggcactt 3314881 cattaaacat aggaagttgt ttcagaaata ataaatagtc acactgattc ataggaaaac 3314941 ctcctgtgct aaggatagct ttagtgtagc tcgactgagc ctgtacagca gtgatgtatt 3315001 tcacagcctg tatgatgaat gtcacttatc aggagggtga atgcatttat aatgaaagaa 3315061 aaaaggagga tttcgatgaa ggcgctgatt ccgaagcagc acggggcgtg ggcgatgctg 3315121 ctgatcccat ttttactcgg catggtcaag ggaggccccg ttatttggca tattccgctc 3315181 ttccttggtt ggcttttcct atacttagcg gtttatcccg ttacgcttgc cttaaaaaag 3315241 aaacaaagca aaccatatca aaagtggatg tgttattacg gttttcccac ctgctgcttt 3315301 ttgatgatct cggtctttca taagccgcct ctcatctggg tgggcgtttc tttactgccg 3315361 ctgtttctca tacatatgta ttttgcccgc agaaaaaacg aacgagcctt attgaatgat 3315421 gttgcaggtg tcttgttctt ttgttcgggc gggtttgcga gctgctggct ggggatggga 3315481 acccttgacg gctgggcttg gtttattttc ttgcagtctg ctttattttt tatcgggagt 3315541 tccttttatg tgaaatcggt gatccgcgag agaaaaaaca gggcatttgc atactggtca 3315601 tggggatatc acctgctgct ccccttttta tccgctcttt tcggagcagg atgggcgttt 3315661 ctcgctttta tcccgagcag cttgcgggca tggttttttc atggaaggga ttggcccgta 3315721 aaaacgattg gcattctgga aatcgtgaat gcctgcttct ttcttgccgt catgtgcctg 3315781 tttatcacaa ggtaaaaaaa caaggacacc gctgtccttg tttttttcag tcaatattgc 3315841 aaatctccag cgggcaattt tcacactcaa tctcacatcg taaatagtcc cgcttgtgca 3315901 aaataatttt tccggattcg tctatcgaaa taaccccttt tttgcggaga tctccgagca 3315961 tacgattgac gctttcccgt gcagccgcgc aaaactttgc caaatcctga tttgtcagga 3316021 caatgttaat cagaatgccg tcgcttcgct ccactccgta gctgtttgat aagcggataa 3316081 gggtagaata gagcgccccc tttttgccat gaagaagcag atccctgatt ttggactgaa 3316141 tcttccggag gtgcgtgctc atccatttca tgaactcaaa tgtcaaagcg ccgttttgga 3316201 ttaattcttt ttccagctta tttttattaa tgacgagcac ctcgccatcc tctagtactt 3316261 ttgcactgag catatacctt ggttcttcag tgaaaagtgt taattctccg acgatatcat 3316321 gcttttggca gattctaagc gtcaggtctt ttccgtcaga tgtcagcttg ccgatttcaa 3316381 tgagtcctga ttgaatcaga taaagctctt ctgcatccat tccttcccga aacaaatacg 3316441 tgtgtttttc catttttctt ttcgtgctga tcgattccag caattcatac agatcgctgg 3316501 atataagatc actatcagat ggtcgaacag agagaaaatt catgagctca cctcgaagaa 3316561 agtcacgttg tgtgtttatt gtaacgtgaa ttgatttgta cccatcgaga aaaaactaac 3316621 aatcttgtga atgccccagt gttagttgat gctctggctg tttctctccg tgtgtgtttt 3316681 cattctttcc tgccaataca tccatatgac aaggacaaaa ctggctaacg ccacctctga 3316741 aagcgccata aacccgatcg cgtactggcc tgttgcctga aatacactcg ccaatatgag 3316801 cggaggaaaa aagccgccta aaccgcccat ggcagacaca atcccattgg caatccccgc 3316861 ttgcttcgaa aaatagaaag gcaccagttt aaaaacagtt ccgtttccta tgcctgagca 3316921 gacggccacg gttaatgatc caaacgtata aaggccgatt gtcggcgaga acgataggat 3316981 aatgcctgat aatgtaagcc cggcaaaaac aaacatcaag atgcggagcg ggctcatttt 3317041 atcagccagg aatccgcccg caggcctgag cagcgtagaa accgcaataa agccagccgt 3317101 ccgcaagccg gcatctgcag gattcagccc aaaatgctcc accagaaagt tcggcagata 3317161 gatagtgaag gcgacaaagg caccgaacgt aataaaataa aacaggctca gaaaccatag 3317221 cacatgattt cggtaaacag ctttgatttg agtcttaaca gaaactttga ccttcttctc 3317281 atgcctgtcg ccaaacaata cgtgcagtaa ggcaaagaca gccagcaaaa tcagatacat 3317341 ttgcacggtt gatttccacc cgacggcttg agcgataacc ggcgctgcaa atgtcgtaac 3317401 ggctgtcccg atatttcctg caccgtaaat cccattgacg acaccgtgct tttctttcgg 3317461 ataatatttc gggagggagg tcaccccaat ggaaaacacc gctcccccga tccctaagaa 3317521 aaagccgcct gcgattaaat caaacagaga atccgcgata ctgatccaaa atacaggaaa 3317581 taaaagcagg atgaagctga ccataaacat gagccgcgcg ccaaacctgt tcgttaaata 3317641 ccctaaagga atgcggagaa gcgacccgag gatcacagga atcgcggtca ctaaagaaat 3317701 ctcacccttg cttaaatgaa tatctaatgt gatttgggaa atgagtgatg aaatcagcac 3317761 ccaaaccata aaccctgcca ccaagcttaa tgactgtaac gataattgaa tgtgttgacg 3317821 gttgatcatt tggcttgccc ctttcaatga ttcaataatc agtcttatca tacaaaaact 3317881 agccaaacag gattgtgaat tacatcacac gtttttctca taaaaaaagg acaaagcccg 3317941 aagactttgt ccttttgatc gtgattacat tttttccgga gccgatacgc cgatcagctg 3318001 aagcgcattg ttcagcgtaa tttgcgttgc cttcattaaa gccaggcgcg cgcggctttt 3318061 ctcttcattt tcagggtcga tgactttctc tgcgttgtag aagctgtgca gagcagaagc 3318121 cagatcataa atatagttag tgacacggtg cggaattcgt ttttccgctg cttccgccac 3318181 tgcctctggg aagccgccga tcgttttcag cagatcgtat tctttttctg attgaatatg 3318241 gctgaaatca agatctgccg ccggtttaag cccctgctct tccccttggc gaagcatgct 3318301 gcaaatacgg gcatgcgcgt attgtgcata atacacaggg ttttcgttag atgttgatac 3318361 agcaagatct aagtcaaaat ccatatgggt gtctgcactt cgcattgcaa agaagtaacg 3318421 cacggcatcc aagccgactt cttcaatcag gtcacgcatc gttacggctt taccggtccg 3318481 tttgctcatt ttcattttct cgccgttttt gtaaaggtga acgagctgaa tgatttctac 3318541 ttcaagcgtt cctttttcat agcccagcgc ttcgattgcc gctttcatac gcgggatgta 3318601 gccgtggtga tcggcgcccc aaacgttgat cagcttatca aagccgcggt caagcttgtc 3318661 cttatgatac gcgatatcag gaagaaggta cgtgtacgtg ccgtccttct tgatcaatac 3318721 gcggtcttta tcatcgccga aagtcgtgga acggaaccaa gtcgcgccgt cttcttcata 3318781 gacgtggcct ttttcgcgga gcgcttcaag cgccttgtcg atttttccat tttggtacag 3318841 tgaagtttct gaataccaca catcaaacgg cacacggaag ttttccaagt ccttgcgaag 3318901 cttttccagc tcgtatttca ggccgtattc acggaaaaac gcgaggcgtt cactttcctc 3318961 ttcgttaacg aaacgatcac cgtattcctc agcgagacgc tttccgatcg caatgatatc 3319021 ctcaccgcgg tagccatcct ccggcatcgg tttttccaat ccgagtgctt caaagtaacg 3319081 gacttcaaca gaaagcgcca gattgttgat ttggtttccc gcatcgttaa tgtagtattc 3319141 gcggcttaca tcgtaacccg cttttgaaag cacgttgcac aaggaatcgc cgacagccgc 3319201 cccgcgcgca tgcccgaggt gaaggtctcc cgtcggattc gctgatacga attctacctg 3319261 aactcgttca ccgtttccga tgttcgtttc cccgtatgct tcccctgctt ccagtacaga 3319321 cggaatcagc tttgttaaat attgattgtt catatagaaa ttgataaaac ccgggccggc 3319381 gatatccagt ttttcaatcg aagccttccc tttatcaaaa tgggcgacaa tctcttcagc 3319441 gatttgacgc ggcgcttttt ttgccactct tgccaactgc atcgccatat tcgttgagta 3319501 gtcgccgtgt gttttatctt tcggtgtttc taaaacaaca ttgggaatct ggctttcttc 3319561 agccagtccc gctttcagaa cggccgcttt gatttcttct ttcagcacgt ccttcatttg 3319621 ttccgcaatg ttcatgcgtg agttcctccc tcatacgtga tcgtcatatt atgtaaatgc 3319681 tcctgctcgt ctccgacatg catgtcatat gcgatgctga tacggccttt ttcttcatcg 3319741 agatcagatt gaatcgattt tgtgcttgtt ttcagctcaa gctcaccaaa tgacatttta 3319801 tatttagcaa ttgtggaagc tcccgttacg aaacgctgat tcattttgac agcgcctgac 3319861 ctcatgacca ggacttcgcc ttcgcttact ttcacaatcg ttttgacttt gcctaagtcg 3319921 tgttcttcat aataagatag atacacttta ttttgtttta catagtaaaa tccggtggtg 3319981 cggaattcga tgacttcttg gtttccgtca tcctcgatca cagacttcac atggagtgtt 3320041 atcggtgtct cttgcttcat tctgacacgt ccttttcatc attccacttt gacttgaata 3320101 gtataatcat tcggtttgta aacttcaact gcttctatct taccatcatt gctcatcaga 3320161 tttgaagata aacctcataa aaagcatttc cttatataga agagaaaatc atatcactaa 3320221 ttacctttag gaaatgttac gagctcgcta catcgcaatc gcagacggac ccgcgccaac 3320281 cggaatcacc gtcacggctg tataatcact tgtgcggtac acggtcacag cattgtcgtt 3320341 gggctgtgcc gcataaatat actgtttgtc cggcgttacg gcgaggtcaa aggcgccggg 3320401 gagagacacg tttgcaatga tcctctgtct ggccgtatta actacgtata agttattaat 3320461 gagaaacggt tcactatatg gctctagaaa ataagctcta gtactatcga gagaaaatac 3320521 aatcgtcctc agcgtttcaa ataaacggct gaagtcccct cccctgctta atggtgacaa 3320581 actaatctcc gttacacctt tcggccacag ctcaccattc aatacgtacg caaaatttcc 3320641 agcgtaagga gttgtaatta aactgggaaa ttcaaatgta tctatgatac tttctaccaa 3320701 ctgcccagta tttacatcat atttatcaac cgaccaactg cttccattag cggtatagac 3320761 atactgtcca ttcggatcaa gagcaaagtc taaagcgccg ggtatcggaa tgacatcaat 3320821 gaccgattga gaggccgtgt taatcacata tatagatccg gcggccatca cgtatgcgaa 3320881 ctcatctgtt ggatcaaatt cgatttttct cggccctcct ccaacagtaa tggtatttat 3320941 gatggttaat gttttattat caatcactga gacaaggttg gtatttccat ggaggacata 3321001 cgtgaatgct ttatcgaaag taacgcctag attagttggc acgtcagaaa aagggattgt 3321061 ttttacaaca gtgtttaaat ctgcatcaat aaccgaaacc gtgctgtctc cagtattggc 3321121 agtaaacaca tacgattgag ggtctggtga tggcggtaaa acaagtgtcc cggccaccgt 3321181 aagcggactg ccgtagaaag gcggtacaat gagcagatct tccactgtta tttgactgaa 3321241 atcaggacag cggccagact gtgctgcata ataaacaact tgatcaatct cttcagtatg 3321301 aatcacagaa acagccccgt ctccttgtcc atattgattt cgtacaggcg acacactgac 3321361 aagaagcgta atggtccctt gtactctcac agcatatcga acaccgatat cttctggttc 3321421 cggcccagtc tggattaagc aaggctcact gatacaggac aaattgtctg tactccatgt 3321481 aacagccgct gacgcttcgg ccgtatcaac cttgaagccc tcagggaaat ctatcggcac 3321541 ttgaaacggc gcttcccggc taatttcctc atcacaaaaa cagaaacaat tttcctgtaa 3321601 agcagaaaga tcattctttt tcatgatttc acgtcctttt agaaatgcac aacatgcagc 3321661 ggttaaatcg taatggcacc cggtgaaacc ccaagagata tcacagtttc ctcagaataa 3321721 tcatctgtgt tgtaaacaat gatgctctgc tctataaaac gagttgcata cagaaaatcg 3321781 ccattcgggg taaacgcata gtctgttgct gattgcggaa catttcctat aacgcctgct 3321841 ccatttggac tgacagaata taaattgcca gtgaagccgt catataaata cacctctgct 3321901 ccactcgtaa acattcgata ttccccttca tactccagct cttgggtgct gctgatggta 3321961 aacgtattta aatcaataac cgtcaaataa ttaaaaaaga attcttgttc taatacatag 3322021 gcataccgct ccggccaatt tgtttctatg gttgatacga taagctctcg ttcaattgtt 3322081 cctgtgactt caccggtagt taggtccact ttttgcacta ttccaaaatt cagaacatag 3322141 gcgaataacc cattgggatc gattgcaaca tcatatcctt ccacaggaat cgacctatcc 3322201 acagttaacg tatcaattcc aatcacataa accgcagtac cggtgaaaac ataagcaaac 3322261 tcatgattag ggataaatct aatcaatcga ggcggctgat ccagcaatat agttgctgtc 3322321 actgttaatg tgtcataatc gatgacagaa atcacattat tgttgggatg taagacaaac 3322381 acagcgcttt tatctggcgt aatttcaata cctgccggat tgtacggaag agcaatcgtt 3322441 gtcacaacag tatcggtgtt tgtatcaatc acagaaactg attgatcatt tggattcgct 3322501 gtaaacgcgt agacgggttc cggctccggt acaagcacaa ttgtccccgt caccgataaa 3322561 ggactgccgt aaaacggcgg aacaacaaca aggttctcaa tcgtgatgtc actgatatcc 3322621 gggcaatcat ccgattcatc ggaataatag acgacttgat cgatttctgc attgtgaatg 3322681 acggaaacag ccccgtcccc ttgtccatat tgatttcgga caggtgagac actgacgagt 3322741 agcgtaacgg ttccctgcag gcgcactgca aattgaacac cgacctcatc aggctcaggc 3322801 cccgtttgaa ttaagcaacg gtcactgaca caagaaaggc tgtctgcatt ccacgtcacg 3322861 tttgcaacag cttcagccgg atcaacgaca aacccttcag gtaattcaat cggtgcttga 3322921 aacatggctt ctcggcttgc ttctccctca caaaaacata agcactcttc ttgttctgct 3322981 cctgcttttt ctttaaagga aagcttgttt tttctcattc cttcacttcc ttttcagaca 3323041 tacactgctc acgcagatat aacagaatat ggaagggtaa cgtgtttgct tgtacaaatt 3323101 gctgagggta aacgcttctt tttgaaaata tatctccaaa catgcggtgt aacgaaagaa 3323161 aaaattgcgg tttttttgcg cttctcacaa gaatgttgat gataaaatat gacatatata 3323221 gaattatgaa gggagggatt tgcaaacgtg acaggtgtca tatcttcttc ttccatcgga 3323281 gaaaagatta acgaatggta tatgtacata cgccgattca gcatacccga tgcagaatat 3323341 ttgcgacgag aaatcaagca agagctggat caaatggaag aagatcaaga ccttcatttg 3323401 tactattcac tgatggagtt tcggcacaac ctaatgcttg agtaccttga accgttagaa 3323461 aaaatgagga ttgaggaaca gccgagactg tctgatctgc tgcttgagat tgataaaaaa 3323521 caggctcgtt taactggtct gcttgagtac tattttaact tcttcagagg catgtacgag 3323581 ctggaccagc gggaatatct gtcggctatt aaatttttca aaaaggccga aagcaagctg 3323641 atattcgtta aggatcggat agagaaagct gagtttttct ttaagatgtc tgaatcttat 3323701 tactatatga aacaaacgta tttttcaatg gactatgcac ggcaagcata tgaaatatac 3323761 aaagaacatg aagcttataa tataagattg ctgcagtgtc attctttatt tgccaccaat 3323821 tttttagatt taaaacagta tgaggatgcc atctcacatt ttcaaaaagc ttattctatg 3323881 gcagaagctg aaaagcagcc ccaattaatg gggagaactt tgtacaatat cgggctttgt 3323941 aaaaacagcc aaagccaata tgaggatgcc ataccttatt tcaaaagagc aatagctgtt 3324001 tttgaagaat caaatattct tccttcctta cctcaagcgt attttttaat tacacagatc 3324061 cattataaat taggaaaaat agataaagct catgaatatc atagtaaggg aatggcttat 3324121 tcacaaaagg ccggagatgt aatatattta tcagagtttg aatttttgaa atctttatac 3324181 ttatcaggcc cggatgaaga agcaattcaa ggattttttg attttctcga aagtaaaatg 3324241 ttgtatgctg atcttgaaga tttcgctatt gatgtggcaa aatattatca tgaacgtaaa 3324301 aattttcaaa aagcttctgc ttattttttg aaggtggaac aagtaaggca acttattcaa 3324361 ggaggagtga gtttgtatga aattgaagtc taaactatta ctctcttgtc tggctctaag 3324421 cactgtgttc gtggcaacaa ctattgcaaa tgcacctaca caccaaattg aagttgcaca 3324481 acgaggaatg atttaaccgc cgtccatcgg cggttttttc gtcccctctt taccaaagtc 3324541 tcccaatcca tgctatgatc ttttcaataa tcttgaagag agtggaaatg cagcatgtct 3324601 ctaaaaagtg tgagaaccca ctttactcaa tggaatcgag aaaatgatgt gacggagttc 3324661 gaaacgtcga gtgcgacagt tgaacaggca gctgagacaa tcggcgtaag cctgtctaga 3324721 atcgccaagt ccctgtcctt cagaggggaa ggagatcagg tgattctgat tgtggcagcc 3324781 ggcgatgcca agatcgacaa caaaaagtcc aggcaaacat ttggctttaa agcaagaatg 3324841 ctctctccta atgaggtgct ggagcagaca ggccatgaaa ttggaggagt ttgcccattt 3324901 ggattggctc atgatcctga ggtttatctt gatgtatcgc tgaaacggtt tcagactgtt 3324961 ttccccgcat gcggcagcag aaactccgct attgaattaa caccgaaaga attatccgaa 3325021 ttttctttct caaaagtgtg gattgatgtt tgtaaagact gggaataaaa aaacatccag 3325081 acatcgtctg gatgtttact tatttcacaa acccaagcag catttcacgg atgattttgc 3325141 tggctgtgtt tgccgtttgc tctgagtggt cgtataccgg cgcgacttcc actaaatcag 3325201 cgccctttac gtttacctct gaacgcgcaa tttcatggac cgatgcaagc agttctttag 3325261 acgtgatgcc gccggcgtca accgttcctg tacccggtgc gtgtgcaggg tctaatacgt 3325321 caatgtcaat tgtgacataa accggacggc ccgccagctt cggaagcacc tctttcagcg 3325381 gttcaagcac ttcaaatttt gagatgtgca tgccgttttc cttcgcccat tcaaactctt 3325441 ctttcatgcc ggaacggatt ccgaatgaat acacattgtg cggtccgatc aattctgccg 3325501 ccttacggat cggcgtggag tgagaaagcg gttctccctc ataatcaaca cgaagatctg 3325561 tatgtgcgtc aaaatggata atcgcaaggt ctgggtattt cttgtacatc gctttaatga 3325621 caggccatga cacgaggtgc tccccgccca tacccattgg gaacttccct ttttctaaaa 3325681 tgctgtccac gtactcttca atcatatcca ggcttcgctg cggatttccg aacggcagcg 3325741 gaatgtcgcc agcgtcaaag aagttcaagt cagccagatc gcggtctaaa tatgggctgt 3325801 attcctcaag gccgattgac acctcacgga ttctgcttgg accaaagcgt gagcccgggc 3325861 gatagctgac tgtccagtcc atcggcatgc cgtaaagaat ggcgtccgcc tcttcccact 3325921 cgggacggct cgcgataaat acttttcctg aataagcttc atcaaatctc atctataata 3325981 ccctcgcttt cctgtaaaaa agcgcaagat tcgctcctgc gccatacctt cattatttaa 3326041 tcaggtcact cacaaatttc ggcagaacaa acgccgcttt atgaatatct tttgtgtaat 3326101 atttcgtctc aatatcgaag aaacggctgt cttccactgc aagcggatca tattttttcg 3326161 agccaattgt aaatgtccac aaaccgcttg gatatgtcgg aatgttcgcc gtatacagct 3326221 tcgtaatcgg gaagatttcc ttcacgtcgc gctgtacatt tgtgattaat tccggtgtaa 3326281 accatgggtt gtccgtctgc gcaacgaaaa taccgtcttc tttcagcgct tttgcgattc 3326341 ctgcgtagaa tccttttgta aacaggttta cagccggtcc gactggttca gtcgaatcta 3326401 ccatgatgac gtcatattga ttttcagatt ttgcaatgtg cataaatccg tcatctacct 3326461 gcacgtcaac gcgcggatca tccagtttgc ctgcgataga aggaaggaac tttttagagt 3326521 attcgataac cttgccgtca atatctacaa gtgtcgcttt tttcacgctt gggtgcttca 3326581 ggatttctct gataacgccg ccgtcaccgc cgccgactac gagaacgtgc tccggatttg 3326641 ggtgcgtgaa taatgggaca tgcgccacca tttcgtgata aacgaattcg tctttttcag 3326701 atgtcatcac catgccgtcc aaaaaaagca tgttgccgaa ctcttctgtt tccaccattt 3326761 ctaaatgctg aaactccgtt tgttctgtat gtaacgtctt gttaaccttc atcgtaatgc 3326821 caaagttttt cgtctgcttc tctgtgtacc aaagttcgct caattgtcat ctccctttcg 3326881 aggctgtatt catttattgt aagcgtctta tcagctttta ttctcggttg aaatctcatt 3326941 ttcacctaag gaaaaagtat agaggatggc ggggaaaaag taaagatgcg tcctgttctg 3327001 cgatgtttaa aaacgatctt tttttctcat aatagtagaa acataaaaaa agggggaacc 3327061 cgttgtggat gcaatgacaa ataaacggct gagactgacg ctgaaaaccg ttcgcgcctt 3327121 tatcttttta ggggcttttg cggccttggc ggcagctgct gtgtttatga ctgtcatttt 3327181 gatagccaaa taccagggcg ctccctcggt gcaagtgccg caatccacga ttttgtacgc 3327241 gagtgacggc tcaaagctcg gggaaacgaa ctacggcgaa aagcgctatt gggtcccctt 3327301 aaaggacatg aatccgacga tcgtaaaagc gacagtggcg attgaagacc agaatttcta 3327361 cgatcatcac ggctttgatt ataaacgcat ggccggcgcg gcgcttgctg acctgaaagc 3327421 atttgccaag gttcagggtg caagcaccat cacccagcaa tatgcgagaa acttatacct 3327481 tgaacacgac aaaacgtgga aacggaaatg gaatgaggcg ttctacacga tccgtctgga 3327541 acaaaactat tctaaggacg agatattaga aggctattta aatacgattt actacggcca 3327601 cggcgcctac ggcattgaag cagcttcccg cctgtatttc ggcaagcatg ccaaaaacct 3327661 gacggatgcg gaggcggcgc ttttggcagg aatcccgaaa ggcccttccg gctattcacc 3327721 gtatgtcaat gagacgaagg ccaaggaacg ccagaaaacg attgtgcgga tgatggaaaa 3327781 gcagcagatg atcagccaaa agaaagcgga tgaattgatc aaggaacctc tttcctatca 3327841 gcctttgaat aaacaagttt ccaagagaaa ggctccttat ttctacgaca atgcgatgag 3327901 agagctggaa aaaaagctcg gcatgacacg ggagcaaatt gaaacgagcg ggttaaacgt 3327961 ctatacaacg gtagataaac ggatgcagcg catcgccgag gagaccatta ccgaaacggt 3328021 taacgcgggc tctgacattc aagtcgggtt ttcagccatt gatccccgca ccggaaacgt 3328081 tctcgccctt gtcggcggca gggattatca aaaaagcccg tttgaccgga cgacacaggc 3328141 gaagcgccag cctgcttcga cgatcaagcc gttgctgtac tataaagcga ttcagagcgg 3328201 atttacgcca gtcactttga tgaaaagcga agaaaccgag tttcaaattg atgcaaaggg 3328261 agaaacctat tctccaagca actataacgg atactatgcc aacaagccga ttacgcttct 3328321 gcaggcgctg gcgctttccg acaatattta cgctgtgaaa acgcatcttt ttctcggcac 3328381 gaacaaactt gtaaagacgg caaaggaatt cggcattacc gcccatcttc aagcactgcc 3328441 gtccctggca ctcggcaccg aacccgtacg tccgattgag atggtcaacg cctatgccat 3328501 gctcgcaaat ggcggaaaga aaatcgaacc gacttttatt tcaagagtaa cggacgcagc 3328561 cggccacgtg ctgtacgaaa acccgaatca gcataaacag gtgcttgatg aaaaagccgc 3328621 ttttgtcaca gcgagtatga tgacaggcat gtttgatatc gatttaaatg gatatacgtc 3328681 ggttacgggg cgaacgatag ccaaccgcct gacaagaacg tatgccggaa aatcaggaac 3328741 caccagcgca gacagctgga tgatcggctt caatccgaag ctggccgccg gtgtttggac 3328801 cggctatgac aaaaacagca ccatcgactc ggtcgaagaa aaaagctatg ctaaaaccat 3328861 ttgggcggac ttcatggagg acgcgctcaa aggcgaaccg gaaaccgcgt tcaagccgcc 3328921 aaaaggcgta accggtgtgt acattgatcc ggaaacaggc tactcatcag gtcccggctg 3328981 cgccgctaag cattacacat attttgtgaa agggacagaa cccgcaaacg tgtgctacgg 3329041 ggcagaaccc gcaaaacaaa caaaagaccg gcttccatcc aaagaaaagc ccgcttccga 3329101 gaaaaagtgg tgggacaaat ggctggggcg acatcattga aaataacccg gctcctcgga 3329161 ggccgggtta ttcgtatggt tccttcataa tcgatggaag aatgttagac aatcgagctg 3329221 aacaatcagt tttgggataa agtggtgaat ttctcatttc ttcggcgctg gctttcatct 3329281 cccagtcgcc gactcatatc cccctaaaaa tgaaaaaccc cgagtcttgt ttcggctcgg 3329341 gattttccat gtcctatttc tgtatcacca gtttactcaa tgtttacgaa aaatatctca 3329401 aatactttaa aagttcacaa aaaattcata aattaattgt tttctggaag caggctcgtt 3329461 tttaactcat ctgaggaacg gtcccatagg ccctgatcat gctttttcag aaattcgcct 3329521 agtacacgct tcgagctgtc gtccatttta tcaacgatga ttttccgttt catggattta 3329581 tccatcagat tcacatgctc aggcagtgac ttgtagcctc ttctgatgct tctgtcgacc 3329641 gtcatttcac aggctgtcac accagcgtaa taaggcccct cttcttttct gtcaatcgtt 3329701 acccacacaa gccagtatgg ttttccgttc ggcacttctt ctttattcgg gagaaattta 3329761 attccttttt caacggtgct gcgggcatgc atagcgccga tgtctacgaa cgcttctttt 3329821 tcctctacat caacgaatac gggagaaatg ttatcaaggc tgagtgcccc tacgccaaaa 3329881 ccgccgtgtc cgtctgtcgg atcacttttg ataatattaa acccgattga ttttttcttt 3329941 ttttcttcca tgaagttcta cctcctacaa aagcggttga aatatcgctg aaaacagctt 3330001 taaaatcgaa tctcttcctg cattgagcat cggccacagc acgtaagatc ctagcggtgt 3330061 cacaaacagc accaaaaata cgataaagcc gtagctctcc gcctgcgtca ttttggcacg 3330121 cacgcccggc ggaacgagat cttctataat tcgatagcca tcgagcggag gaagcggcag 3330181 cagattaaat aaaaacaaga caagattcag ctgtatccaa atagaaaaaa actgatccag 3330241 ccccgtgctg aacgccgcaa gcatttccat tccgtacgca tgcatcaaca ctaacaaaaa 3330301 gaaaccaata aacgcaagaa tcaggttact gacgggcccg gctatagata cgagcacacc 3330361 agcaagccgg ggtttcttaa agaaacggcg attcacggga atggggcgcg cccacccgaa 3330421 tccggccacc agaatcaaaa tggttccgaa cggatcaagg tgtttaatgg gattcagcgt 3330481 cagtcttcct tgttttttcg ccgtatcgtc accgaatttg tatgcgacat aagcgtgggc 3330541 aagctcgtgc atcgtaaacg acacaattag cgtgatgacg aggtatggca ttaaagataa 3330601 cggataatat aaaaaacggt ccaagtgaga tatccctctt tctcaaaatg caagaattta 3330661 ctttattcag tatactataa gaagcctctt tttctaaaga gaggaaacga gataaaggag 3330721 gattcagcac ccatgccata cgtaactgtc aaaatgctcg aaggccgtac agacgagcaa 3330781 aaacgcaatc ttgtcgagaa agtaacagaa gccgtaaagg aaacaaccgg tgcttctgaa 3330841 gaaaaaattg ttgtctttat agaagaaatg agaaaagacc attatgccgt cgcaggcaaa 3330901 cgcctgagcg atatggaata atctctataa agccggcgct tcgcgcaccg gcttttatta 3330961 tccctattga gccagcttcg caataatcgc caagaacgtc tttttctctt cggctgttaa 3331021 acgttcaaac atgccatcaa tcagctgctg gcggttttcg atcatttgtt cagccgctcc 3331081 ccggcccgat tcagaaagag taatccatac agtgcggcgg tcattgttat ttctggatct 3331141 ctcaataaac ccttcctgct ctaaatgatt cagagctgtg gtcgtggcag agggagacag 3331201 tgtgacctcc ttcaaaatat cctttatggt gcagctccca tgtctgtata tgatccgcag 3331261 aataaaccct cttacattat tcacgtgttt cggaacggtg gcttcatcta attgcttcgt 3331321 gcttttcaaa tactttgtaa gtgcgtgatc cagcaaattt gcttccagtt tgtcatggtc 3331381 catgtcaatt tccccatttc gagatgcatt cataacatac gaacgatatg atttacttat 3331441 tattttactg attccgaata gggaaagtca aaaaagcaaa atgtgaattc acagctttta 3331501 tcctacatgc ctcgattttc cacctgtttc acaagtttat ctttaaaagt ttggaaagga 3331561 acgtgttcat tctgctgatg tccgaatcgg cggacgttta ccgcattctc ctgctcctca 3331621 tgatctccaa gcaccagcac gtacggaatt ttttgcacct gcgattctct gattttatag 3331681 ccgagcttct cattgcgctc atcaatgccg gctcttatcc ccgcctgctt cagctccgcc 3331741 tgcacttttc tgcaatagtc taagtgaacg tgcgaaaccg gtatgatttg aacctggatc 3331801 ggtgcgagcc agactggaaa agccccaccg taatgctcga tcaaaatgcc gaagaaacgg 3331861 tcgattgagc cgaaaaccgc tctgtggatg acaacgggac gaaccttctc attgagttcg 3331921 ttgatatatg ttaaatcaaa tttttccggc atttgaaaat caagctgaat tgtcgcgcat 3331981 tggtggctcc gtttcagggc atcttttata tggaaatcaa ttttcggccc gtaaaacgcc 3332041 ccatcgcctt cattgatctc ataagagagg ccaagctcct caaggacgcg tgctaaggca 3332101 cgttccgacg cttcccaaag gctgtcatcg cctaatgaat cctccgggcg agtcgaaagc 3332161 tcaacagaat actcgaaacc aaatgtccga tatacctcat caatcagccg aatcgcttct 3332221 ttgatctcac tctcaatctg atcctcccga acgaaaatat gggcgtcatc ctgacagaac 3332281 gtccgaacgc gaagcattcc gtttaaagcg ccgctgtatt catggcggtg cacctgtccg 3332341 aattccgcca tgcgaatcgg cagatcccga taagaataca ggctgttttt aaagatgagc 3332401 atgtggccgg ggcaattcat cggcttcatt gcgaatcttg tatcatccac ttctgaaaag 3332461 tacatattgt cgcgataatg gtcccaatgg cctgactgct cccataaccg ctgattcatc 3332521 ataaacggcg tacgcacctc atcgtagccg gcatttgttt gcagctcacg cgagaagcgc 3332581 tccagctcat tgcggacaat ctgccctttc ggcaaataaa acggcatccc cggcgcttct 3332641 tcagaaaaca taaacagccc taactgtttg ccgagcttgc gatggtctcg ttttgccgct 3332701 tcttctagca tatgcaggtg cgcatccaaa tcttttttct tttgaaacgc aaccccgtac 3332761 acccgctgca ggacttcatt tttgctgtct ccgcgccaat aagcgcctga tactcttgtc 3332821 agtttgaacg ccttgatcat ccctgtagaa ggaagatgcg gccctcggca caggtcaacg 3332881 aattcccctt gctggtacag tgtgatatcc tccccgcgcg gaatatcctt taaaatctca 3332941 agcttgagcc gctcgtcttt ttgtgcaaac agctcttcag cttcttcgta agaaacctct 3333001 atacgtttga tttcaaggtt ctcatttatt atgtttttca tttctttttc gatggcctct 3333061 aagtctcctg atgccaagct tttccccagc ttcatgtcat agtagaagcc gtctaaaatc 3333121 acaggcccta cccccaatga cacttcgccg tacagccgtt ttactgcttg ggccagcacg 3333181 tgcgctgttg tgtggcgaag cacctgcaag ccttcttgtg aatcgagtgt gacaatcgaa 3333241 agctcagcat cctcctccag cttgaaactg agatcaacaa gcttgccgtt gacctgacct 3333301 gcggccgcct tcttttgcag actggaactg atcgaaccag ccgcttcttt gattgtgatg 3333361 cctttcggat attcctggat ctgtccgtcc ggaagctgaa tgtgtacatg tttgctcatt 3333421 ttagaacact ccttattcat tgttgtatat aaaaaaacac acccgtcccg cagataggga 3333481 cgagtgtgtg attaacccgt ggttccaccc aagttcccga caaatactat gttgtcggct 3333541 cggtgctgta acgcagcata gacggcattg gttacttcag ttccccaatg ctgctccaag 3333601 gcggtaaatg atattcctaa gctgggaagc tctcaccttt ccttccctct ctgaaaaccg 3333661 taactatcat tcatgtcctt ttcatcgcat gtattcaatt cataaaaaaa cacacccgtc 3333721 ccacagatag ggacgagtgt gtgattaacc cgtggttcca cccaagttcc cgacaaatac 3333781 tatgttgtcg gctcggtgct gtaacgcagc atagacggca ttggttactt cagttcccca 3333841 atgctgctcc aaggcggtaa atgatattcc taagctggga agctctcacc tttccttccc 3333901 tctctgaaaa ccgtaactat cattcatgtc cttttcttcg catgtattca attcaaataa 3333961 aaaaacacac ccatccctct aaaagggacg aatgtgttga tcatccgtgg ttccacccaa 3334021 attcccgatc aattacacat gatgatcggc ttaaagatgc tgtaacgcag catgacggta 3334081 tcagatactt gttttccctg atacggctca aaggcggtaa gctgctttcc ctgcgttagg 3334141 aagatctcag ctgtccttcc ctctctggaa accgtaaaaa gcatctcgtg tccttatcag 3334201 tgcctgttgt ttcaataatt ttttatatct tactatatat tcccacaaag cgcaatcagt 3334261 gatttacatt ttttctgacg cggcagtccc gttatgggca gccagaaaca gccatacaag 3334321 caatgcagcg aggctgtatg ccgctcccat catcaaaaac gcaaacccgg caccagcata 3334381 ccaagtggcg gacagatgaa tgatcacccc ggttatcgct acgccgacca aggctccgat 3334441 ttgccggttt gcatttaacg ccgcaccggc gatattcgta tgtctttgcc cggcagcctg 3334501 catgatcaca gttgtcatgg caggaactgt aataccggta cagaggttca taacagacat 3334561 caacaccgcc agctgccaat aaggaaaatc cggagaaatc agcacaaaca acagcaatgc 3334621 aatgatacag ctgaccgcca ttgatacaaa cataagctga ccggcttcaa accgattcgc 3334681 cagacgggca aacagcagat tgccgatcac gaagaccgcc atcatcggca gcagctccac 3334741 tccagccata aaggaacttg cccctcctgc ttcctgcaaa aaaaggctga gcataaacat 3334801 gccgccaaaa agggcgaaat tcagcaaaaa cccgataaat tgggcagctg agaagcggcc 3334861 gtttttgtat aaggacgccg gcaggatggg tgtttttgca gaaatttccc gcagcaaaaa 3334921 cagcacaaat gccaaaaccg ctgcagtaaa tgctacaaga atcactggcg agcgccagcc 3334981 cgctgaaggc ccctgtatca aagcatagga aagaaacccg agagccatca tgccaagcag 3335041 atgcccgatg atgttcacgc ggctgctttt cccaggaacg cggctgagga ttcggtaagc 3335101 tgaaatgagc gcagcagccc ctattggcac attgatcaga aaaatactct gccagcccgc 3335161 caactgtacc agcacgcccc cgataaaagg cccaagggct gaagcggcgg aaacaagcgc 3335221 ggcccacagt ccaaacattc tcgcccgcgc ccgctcatca aggtaagagg cagccaaaag 3335281 gctgagtgag cttggcataa acaaagctgc cccaattccc tgtatgagac gtccggcaat 3335341 cagcatctgc ccatttatag atgcagcgca tagacaggag gccataacaa aaacggctag 3335401 acccaagata tagatcgtct tcgagccgaa acggtcagcc aaggctccgc ccgccagcag 3335461 aagcgacgca aaagtaagaa tgtacccgtc cacaacccac gttacacctg aaagtgacat 3335521 tgaaagagtg tttttcatat cagccatcgc cacattcaca acggtcacat caagagttgc 3335581 catgaggaaa ccaagtgcga gcacgatcag cacggatatg cctgttgatg atgttgattc 3335641 ttgtatagac ccgctatttt tcattacaat tgccctttca cttgcttgat tacccaatca 3335701 tctatttttt caagatcata caattccccg actctgtcca taacatgctg caaggattct 3335761 tctctcataa gattggacca tttatcctcg atttccgcca tgactgtctc cagcacacag 3335821 tgactttcac cctcaaatac agattgcagc aagcctttcc cctgatacat cgaacctctg 3335881 ccttcgaccg cttgataaac atcataaagc gtaatgtcag ccaaaggctt cgtcagggta 3335941 aaaccgccct tcgtccctgg taaggattct gccaaaccgg cttgaaccaa tgttctcatc 3336001 agcttcttca agtaagacgg agacacgcgc aatcgctggc ttatagcctc tgacgtcaaa 3336061 gaagcctgta ccggcagccg tgacagtaac agcagcacag aaaccgcctg ctccattcct 3336121 gatttcattt tcatcctatt cactcctgat tcattatgga taactattat ccataatgaa 3336181 tctcttagca gcttttgtca ataaaaaaag caaaagaaac ggatcatttc ttttgcttgg 3336241 tatggttaac aaatctgctt cagttcctct atgtattgaa gcgcttcgtc atattcttca 3336301 tttgtatatt tttgcttgct tttgatggta aagacttttt ctttcttttc ctcatcctca 3336361 agcccgtcaa agtaaaggat cgtggaaacc agctctaaaa accgtgatga acggctgttt 3336421 acactgtcga tatagccttt catatccggc atgtccagat cagcatggtc taaaaatgcg 3336481 gagcctgtct cagtcagcga ataccggtat tgaaagtagc cgcccttttt ttccttcacc 3336541 tcatgcagaa atccaaggtt gcacagctct tcaatctgga gcgtcagttc ctctgaatat 3336601 ggtccgtaaa agtgaaaatc atatttctca tagaaaggaa actgcatttt cttggcgata 3336661 taaatcattt tctgcagctt ctttcgcccg atgatttctc cagaatccga gaacaccttc 3336721 atcagttttg catgttcttt caacaaattc ccgacatctc ctttttcctt ctttccaatt 3336781 tctatgtcag tcccagcagc tgccggattt tcattttcgc ttccggatgt ttagtgccgt 3336841 cacaaatcaa gtcctttgga tagtacagct tgtggtccgt ccgccgttta cctgagatgg 3336901 attccacaat agccgactgt ctggacagct ctttaatttg gccgttttgc gtcaagagat 3336961 ggatcggcag acgctcctct tcctctcctg gtcggtaaaa atcgtatggc agatctgatg 3337021 aagaatcaac gaccaaataa tagctcggat cgatccccgc ctctttgaac aatgaagtca 3337081 gctcaaaata agccgacatt tcttcattcg gattgaattc aacgtattgg aaaagctggc 3337141 ggttaatgaa tctgcggcac aagtcggata aaatcgcgtc ttcttcatcc tcccaggcct 3337201 ggaagtaata caaaataata gattcatcca gctttacata atcctccagt gtcaattttc 3337261 cttcaaaaat agaatagaaa tgaaccggag cgtgagtgaa gacatagcct tcatcgtgca 3337321 gctgcttcgc cctgtgaaga atcttcgtta aaatgacctc tgcacttcta gtcacaggat 3337381 ggaagtagac ctgccagtac atttggtaac ggctcatgat atagtcttcg acagcgtgca 3337441 ttccgctttc tttaatgacg atctgatcct cgcgcggccg catcacccga agaatccgct 3337501 ccatatcaaa atggccgtag ctgacgcccg tataatatgc gtcgcgctgg aggtaatcca 3337561 tgcggtctgc gtcaatctga ctcgaaatca ggctgaccac ttgcttgttt ttatatgttt 3337621 tggcaatgac ttcagcaaca tcctgaggga aacccgggct cacctttctg agcacctgat 3337681 taacctccgt gtctcccaaa atgatacctc ttgtaaaatc ctcgtggtca aggtgaaaga 3337741 ccttttcaaa tgaatgcgag aacggcccgt gcccgaggtc atgaagcagc gccgcggcca 3337801 aacagagttc gcgctcactg tcatcccatt cagggcggcc tttaaagacg tcatcaacca 3337861 ttcttctgac aatttcatag acaccgagag aatggttgaa ccggctgtgc tcagccccat 3337921 ggaacgtcaa ataggtcgtt ccgagctgct taattctgcg gagacgctga aattcacggg 3337981 ttccgatcaa atcccatatc agcttgtccc gaacatgaac atagcggtgc accggatctt 3338041 taaacacttt ttcttctgat aattttccat ttggatacgc catcgtcatt ccctcttttt 3338101 tttagccgtg tttctattat atcgactcta ttctttgaaa acatccttga atttgcccgg 3338161 cgatttgttc catcttcatg aaaaacacat cttgtgaagc aaaaaagcct gacctgaggg 3338221 ccgaggctaa gaaaaaatat gtttttactt ttttattttc ttttttactt tgtcaatcag 3338281 ctcatcctct gtcggagctg acagcgggcg attgttcaca aaagcaaatg attttttccg 3338341 tccgggcccg caataagatt ggcatcctac ctcaaccttt gcgtccgggt ccacttcttt 3338401 caaacgcggc agcaatgttt tgatattagt ggcttggcaa tcatcacaca ctcgaaattc 3338461 attagccatg acgtacgctt cccttcattt ctatgttcat ctatgtgaat aacctaaaat 3338521 cacgtttcaa aaaaaatcac atcacacttc attttacaag gattcgactg ttcctgcaag 3338581 ccgctccatc cttcgtatct cctattcttt cagccaattt gtataaatat tttccaacct 3338641 ggacattcta ataccatgaa aagaaaaatg ggagttgaga taaatgacaa aacagcgaca 3338701 agacgcttgg tcagaggaaa acgatctgct tttagccgaa acagtgcttc ggcatgtgag 3338761 ggagggcagc actcagctga acgcctttga agaagtcggc gataaattaa accggacatc 3338821 cgcagcctgc ggattcagat ggaacgcagt ggtccgccat caatatgaaa aagcgcttca 3338881 gcttgcgaag aaacaacgaa aacagcggat gagagcgctc ggaaacgggc agcccgcgaa 3338941 aaaaagatta ttatatcagc ctcctgccgt tgatcctgaa atcattcaag aaaccgctgc 3339001 agaagagccg gttaaaacgg aaacaccatc tgtcgaaaat gagcaacctt taatgtctgg 3339061 cgaacacatg ccttttgttg atgaaagctt taaggaagag ttagctagtc tatcacactt 3339121 attgtctcct caaacgcctg cagctgcgcc tgagatgacg atgaatgatg tgatccgctt 3339181 cctgcagaat tacgaaggca atcacgagca atcatcagca ttaaaaatgg aaaacgagcg 3339241 tttaaagaaa gaaaatcagg aattgcaaaa caaaacagag cagctagagg cagaagttca 3339301 aaagcttgaa aaagaccaaa aaacgatcca agaagattat gaaaccttgg tgaaaattat 3339361 gaacagagcc agaaagctag ttttatttga agaagatgaa catgcctctc cgtccttcaa 3339421 aatggaccgg aacggcaatt tagaaaaatt agcggaatga catagaaaaa tcccaaaacg 3339481 ggcagctgtt ttgggatttt cgccatgtgc aaaatcccct tttctattga gaaaagagaa 3339541 tttcctcatt ttgcagccgg atcagctatt cttgtaaaat gaggccaagc ttatgtgaat 3339601 ctattaagac atgtgagctg cctcggccgt tttttgtttc cgaggcgcag cagaaatgac 3339661 caaaagcccc agcatcataa gcgcaatgcc cagccacgag gaaggcgaaa gcatttcccc 3339721 tatgaaaaac acgccaagca atgaagccgt cagcggttca gctaaagaca gcgtgaccgc 3339781 cgccgaggcc ggaaccccgg taagcccttt cgcaaacaaa aagtatgcgg cacatgttgc 3339841 aattaacccg atgtaaaggc ttgttcccag tcctctaggg gtcaatatcc acgagatatc 3339901 taactgccat aatagcggcg tcagcaagat ggcgctgatc atgaatacaa cggcggaggt 3339961 cgctcgcgga ggctgggttt tcatcatcgc tttactgatg agcgtatagc ctgcaaaaga 3340021 agcacccgct ccaagcgcca taagaacacc agccacatca atccgaacat tggaactgtc 3340081 ggaaaacaga agccagcaac ccgctaaagc cagcacagtc gcaatccacc aggagtttcg 3340141 cgggcgtttc ttcaatacag cccattcgag ggtcccggca atgataggcg cactgccgat 3340201 ggcaatcaca gttcccactg caattcccgt ttctttaacc gctgtgaaaa acagcggctg 3340261 gtaacacgcc atacaaacag cggctaaaaa tacgagcggc catgcccaat ttttcacgtg 3340321 aagctcccgg ctgatccaaa ccgcaagcag catggcgctt cctcctatta ataacctgaa 3340381 cgctccaaat gccagcggtg tggcgctttc tggagccaat gcctgaacgg ttcccgtggt 3340441 cccccagaaa aaagccgcaa tcaatacaaa aaggctgtaa atattcccct tcatctgcct 3340501 ctccccttta atatggatgc tgatgtcatt ttatcgtttt tctttttgtc gtggttatct 3340561 gtatgtaaga aggacttatc tgaaaataag attattgagg taaaatgccg cttgagataa 3340621 aaaatgcatg ccggcatata cagccggcat gcgaagaacg ttcacccaaa tacctttgca 3340681 ttccgctcag ccatccggac gaggtttttc tcaaattcca tttcctcatc aatggacagt 3340741 ccagctgaat aaagatgggt gcttaacgct tttaattccg tcaataaagc gaacattaag 3340801 tcttgtacgg agatgtcttt ttgaagaagc tcacttaagg acgccatcgt ttccggacgt 3340861 atttccggat agacgccttt tttatcgttt tgtttgtctt tcagcgccgc ttgatagaat 3340921 cgtctgatca agtcggccct ttcactgccg cttttatctg cacagagata aatttgaaca 3340981 gcgactccgc cgcgaacgcg tctctgagag atgccggcga actttttgcc atttatactg 3341041 aggtcatagc tgccgggaca ataagaccct tcaatttcat aggcttcgat ctttgcgttg 3341101 tacggtctca gcattcgtct catcagctcg accatcgctt catatccttt gtctatatcg 3341161 atgcctttct tttcgtcctc gaatatgaga gagatattta aaacaccgtc atccaatacg 3341221 acggcaagac cgccggaatt gcgtacgatc acacggtatc cttcgctctc cagcaaggag 3341281 ataccatcct gcaaaaacgg gaggcgtgta tcctgtattc caaggacaat tgtatcgtgg 3341341 tgcacccatg agcgcgctgt cgccggcgac acgccttttc cgacggacat gcatagcgta 3341401 tcatccattg cgaaggattg cttcgcatca aataaagggc cgagactgga ttggtcaatg 3341461 actctccatt tcggctgcat cagtaaatca atcggttggt ttgccatcta tgtaaaaccc 3341521 tttcatgtta ggcttattga acgaaaacta ttatatcatt tcagcagctg tgattgataa 3341581 ttgcttttca gcatcgtaat aaaaatttct ttattttttg tattctccat gagaggagaa 3341641 tgaatgtaag acagcttgcg ctttaacgag aaattattaa tatgcagaat tgaaatttcg 3341701 cggtggatca aatccttacg cagcacgctt ctggatagaa ccgaaagtcc catgccgtta 3341761 atcaccgctt cctttacacc ttgattgctg ctgatggtaa acattgattt cggccgaagt 3341821 ccatttgaac tgagtacatg atcgagatat tctctcgtcc cggagccttt ctctcttgtc 3341881 acccacgctt cgttctgcaa atcgctgatc gaaatctctt tccgcccggc gagcggatgc 3341941 tgatttggag cggcaatgca catttcatcc tccatgaacg gttcaatttc cagctcattc 3342001 tcgtttgtat gtccttcaat cagcccgata tcagcctgaa gcatccgcac acgctcgctg 3342061 acctcctctg tattgccaat catgacatct agattcagct ctggatacag cttttgcagc 3342121 tgggccaata gcggcggaag aatatactca ccgattgtaa agcttgcagc tattttcaat 3342181 tcacccttca catagtgatg atgcgcatag atttcagcct tggcttgttc gtagagaaac 3342241 accatttgct ttgctctttg atataaaatg tctcctgtcg gcgttgtcgt aaagtgtttt 3342301 ggcgacctgt tcagaagagc cgtttgaaat tctttctcaa gatttttgat atgcagactg 3342361 acgctgggct gggagatcat cagcttttcc gccgcttttg tgaagttttt ttcttctacc 3342421 accgctataa acgttttcag cacgtcgtaa tacaaaaacc ccacccctgt cattaatgaa 3342481 atatatggtt atgattagtt ttctttattg tactcatatc atccgtcttg gtaaagaagg 3342541 gctatacaga agcgcaaaaa aggcagccct cggtcgagag ctgccattgt cttcaatttt 3342601 attacagtgc ttgcgccgct gtaattaatg cgagattgta aacatcttca gcgttacatc 3342661 ctcttgaaag gtcgtttaca ggcatattta aaccttgcag gattggtcct accgcttcaa 3342721 agttgcccaa acgctgagcg attttatagc cgatgtttcc tgcttcaaga cttgggaata 3342781 cgaatacgtt agcgtcccct ttgatctcgg aatccggcgc ttttttctca gctacagatg 3342841 gaacaaatgc agcatcaaat tggaattcgc cgtcaagtgt cagttcaggc gctttttctt 3342901 tcgcgatttt cactgcatcc gctacttttt ctgtttcatc agattttgct gagccttttg 3342961 tagagaagct gagcattgcc acgcgaggct caatgtcgaa catttttgcc gtattggcac 3343021 tttcgatcgc aatctcggca agatcttggc tgtcaggtgc aatgttgatc gcgcaatctg 3343081 cgaatacgta ttgctcttct ccgcgagcca tgatgaacac gcctgaagtc tttttcacgc 3343141 cttcttttgt tttgatgatt tgaagagccg ggcggacagt gtcagcagtt gagtgagcag 3343201 ctccgcttac aagtccgtct gcaagtcctt tatacaccag cattgtaccg aagtagttct 3343261 cgtctaataa tgctttacga gcctgttctt cagtcgcttt gcctttgcgg cgttctacga 3343321 atgcttgtac aaggtcttcc atgccttcat atgtatgagg atcataaatc ttaacgccgc 3343381 ccagcgtaag gttcaattct tttgcttttg cttggatctc attttcattg ccgatcacaa 3343441 tcggattcag cactttgttt cctgcaagct tgctgaccgc ttctaaaata cgctcgtcta 3343501 agccttcagg aaatacaatt ttaacgtctt ttccagctac tttttcttgc actgttgaaa 3343561 ataaatctgc cacaataaaa cctcctcaaa aagttacaaa aacgctttct tttactagca 3343621 tactcttctt ccaatcaaat tcaaacagcc aactttcatt atagcgcttt cataaaaaaa 3343681 tcttattttt ctaactaatt taagtgactc aatcttccct tataggttct tctattttga 3343741 tggagttata cggaagggat gttcaaggtt tctccacagt agaatcggat aaactatggt 3343801 atagtgaagg caatcatgaa aagataatgg gagtgaagat aaatgagtga acagcaaatg 3343861 acgaatgaag cggcaaaaac gcttgacggc tggtatgcgc ttcatgattt ccgcacaatg 3343921 gattgggctt cctggaagct tctgtccagt gatgagcgcc aatctatcat acatgaattc 3343981 accgggttgc ttgaaaaatg gggcgtagcc caaaaagaag gaaaaggatc gcaaactctt 3344041 tacagcatcg tcggccaaaa agctgatttt atgctgatga tccttcgtcc tacaatggaa 3344101 gaattaaatc aaattgagct tgaattcaac aaatcaagac ttgctgagtt caccattccg 3344161 gcatactcct acgtatcagt ggtagagctg agcaactact tggcaagcgg tgacggcgat 3344221 ccttatgaaa atccgcatgt gcgcgctcgc ctttaccctg aactgccgga atctaaatat 3344281 gtatgcttct atccaatgga taaaagaaga tctggcaacg acaactggta tatgctttca 3344341 atggaagaac gcagaaactt gatgagaagc cacggtttaa tcggccgcag ctatgcgggc 3344401 aaagtcaaac agatcatcac cggctctgtc ggctttgacg attacgagtg gggcgttaca 3344461 ttatttagcg atgatgtcct tcaattcaag aagctagtgt acgaaatgcg ttttgacgaa 3344521 gtcagcgctc gctatggcga atttggttca ttctttgtcg gcaatcacct ttcgcttgat 3344581 acacttcctc aattcttata tgtataatat ccccgagctc gtttattgag ataaggactg 3344641 atcggccttc tgctcaagtt tgccgtactt tttatatgcg aatacactga gcacaaatcc 3344701 gaggactgtg atggcggcgc aaatcaatcc gacagctgca tagccgtatg ccacatatac 3344761 gggtcccatt aaagcagaac ctaatgtcac ggccagattc gaggcgagac tgtaaaacac 3344821 catgactttt cctcgatgac gctctgagca gtcactcaaa atggtgctga gcagcgtcac 3344881 cgtcaaactt tgcattaatc cccaaataaa taggctggcg attaacagaa acatagacgc 3344941 cggcgcatat ggtaaacacg ccagcagaac gctgatgacc cccagcgcaa tcaaaaggga 3345001 gcgcattttt ccgatgcggt cggctatctt tcctgtaatc acactcatgg aaaacccgat 3345061 tccataaatc atgataaata agcccgcagc cgtgtttcct ccggtaaaaa cgtcctgaag 3345121 ataggtgcct aaaaaggaat acataccgta aaaaccaatc atattacaaa aggttattgt 3345181 gatataaaca ggtacacgag ggactttcag cgcatcccgg aatgttcctg cgggctcttc 3345241 tatttcttcc ttgccgctgt ttttatgttg ggcatggcgg cgcatttcaa ggagaatcag 3345301 cagaacaact aaaacaccca tcagggcgaa aatccaaaac gtccatctcc aatgcaggac 3345361 gccgccgata aatgatccga gcggcactcc gaaaatcagc gccagcgacc agcttgaaac 3345421 gatcagtccc atcaccttgc cccggtatgt ataaggaaca cgatcaccga caactgcgta 3345481 agcggtcgga acaaacgctc ccgcagccaa tcccgaaagc gcccggccta aaaagaagaa 3345541 aaaaatattt tgagctaaag cgcatatcac cgttcctatg ataaaaatca taagcccggc 3345601 caataagctc agttctctgg agtatttatc gcctaatgga accaaaagcg gcgcaccgat 3345661 aaaaatcata acgccgtaaa tactgataga taacgcaagg acgctgacat ctgagctgaa 3345721 ggcttttgct aaatccggca gcagcggtga gatcacaagc tcttcagatc cggctgcaaa 3345781 tacccccatc gttaaagcca gtgccaacaa taacggaaaa tgatgttttg ttttgatgtc 3345841 attgttttga ttgctgttca ttctttctca aacacctctt ccataatctt cttatcataa 3345901 agttgtatta tagtttagca ttgttttttc tctatttaca attcgaacga aatatttata 3345961 agttttatta ttttcattta aatcccatta tatatttcta tatttcattc taaaaataca 3346021 tgaggatgta acacgtaaaa aaagctctcc ggcctcccgg agagcttttt ctattgcgcc 3346081 tctgtctgct ttttttcaat cgtttcatga tttatacgct ttttgatgct tagatgatag 3346141 tatgcataac agaaaataat gatcggcaca ccgcagtata agccaattct ttgatccgga 3346201 atgaaaataa ggctgatcaa cacgcagcca tataaacaaa atccgagaat cgggactagc 3346261 ggataaagcg gcgttctgaa ctccagatca ttcacatttc cgccttctgc caggaaacgc 3346321 ctgcgaaaga aaaattgcga cgcacaaatg gacatccacg cgacaactgt caccatgccc 3346381 gagattgaga tacaccataa atacactgtt tctgcagcca tgacacttgt cagcagcgaa 3346441 cagcctgaaa tgcctagcgt aatcagcagg gcattcatcg gcacgccttt ttttgtcagt 3346501 ctggtgagaa aggagggacc catttgattt gatgaaagtg accacatcat acgcgacgcc 3346561 gcatacaatc ccgaattagc aacagataaa atggccgtta agatgacaaa gttcatgata 3346621 tctgccgaaa atgggatgcc gatttgatcg agtactgcta caaacgggct ttcaatcacc 3346681 cccgccgttt tgtacggaag gatggcaacc aagacgaaca tagcgagcac aaagaaaaac 3346741 agcgtgcgcc aaataacatt tcgaatggac tttggcagtg ttttttccgg gctttcactt 3346801 tcccctgccg caatgccgac aagctccgtt ccctggaacg agaagtttac catgaccagc 3346861 gtaaacataa cggccagcac cccattaggg aaaagccctc tatcagtcat aaagttagac 3346921 aaaaagggtg tctcctgtcc gcctttaaag tcaatcaagc caaacacagc ggctccgcca 3346981 atcacaataa ataatatgat cgccgccact ttgatgcttg aaaaccaaaa ttccatttcc 3347041 gcaaagcttc tgacagagag cgcattaatc aaaaagatga cgatgccgaa cacgaggcac 3347101 catatccaga tcggaacgga gggcagccac ctttgcatca aaatgcctgc tgacgtcagc 3347161 tctaacccta ctgtattggc ccagctgaac caatacagcc agccaatcat aaagcctgtc 3347221 gactgtccca gaaatttagt ggcgtaggcc tgaaacgatc cggccaccgg catggcaaca 3347281 gccaattctc ctaaacaaag catgacgaga tacattaaaa atccgccgat gatatacgcg 3347341 gcaatggcgc cgagcggtcc cgcctggcta atggtaaagc cagagcctag aaacagccca 3347401 gtgccaatca cccctcccaa agcaatcata aacaaatgcc tgcttttcat gctgcgctgc 3347461 aattcatttt tatgattctg catcatcctt ccccctttgg ttcttttgcc gtgatggtca 3347521 tccggtagct ttgcaaaaga tgaacggtgg tttgctgtat gaggagaggc aatacatgaa 3347581 atgtgtacgg tttatagact cgttctgtcc atttatggcc gtcttttccg tacacgccca 3347641 tattaatgga tggaatattc agcttgcgta tgtctttgaa cggaatggtc ccaatcatat 3347701 tccacccagg gaagttcctg ataaaagaat caatttcgcc atcggtttcg tgcagtgata 3347761 aaaaactgcc gtctgccaag taggggaaaa actttttgaa gacaaatgtt tcgcctgtcg 3347821 attcagcggt tttgtcagcc gcttctttaa tcacatgctg caaaagctga tctcttgcgc 3347881 tatcttcttt caaatagtta tgcggcaggt aaggaggtgc gtaaaataga atgacttttg 3347941 cgccttgatc ggggtcaagc ttttgaagct cttcgattgc ctgaaagcat ctcatgcgaa 3348001 gttcaaggtg ctcgttggct ttgaatgtct gctcgataca ctgctcggga tctattcccc 3348061 ggtttctcag cttttctaag tattgctcca ggctatacac ttgaatgccc catgataaat 3348121 gtttctttgg caggttggct ctttttacat attcttcgta ataatctgat aatttttgtt 3348181 ctgtctcccg gcatgcttcc tcagtgactt caataagcaa atccatcatt tcttttgctg 3348241 ttctttcata aataaaacaa ttgaaataca agctggtgct gacagccgtt tgcacattat 3348301 aggattcctt gttatcacgc tgatacaaac aggatggggg cagaaccaac tccccttcaa 3348361 ccttttctgc cagatggatg ttattgtgga gacggcttgt gatttcagat gaaatgaaat 3348421 ttgggtcaat ccctgccagt gtatcgccaa catggacttc acgcccgtaa atgtaaaagc 3348481 aaggcaacag ttttcccgcg gctccggtat agatatatct tgtctgatca ccatcgtaaa 3348541 gcggggtaat aaaatccgta ttaatagcag ccaaatagtg aagctgtttt tcttttttta 3348601 gccggttcag ctctgaaatg ctggcgagaa tgcccgaatg ctggctctcc tcatcgggat 3348661 tggccataaa caatacattt cccggcaacg tctcaaggtt ctccgaaaaa tgcaggagat 3348721 tggctaaatg cacggcgatg ccgctttgca tatcgacaga tcctcttccg aacatccact 3348781 cgcctgattt ggcatcccgc tgaacatcct gatcgaactc atagcggctg aaatactcgg 3348841 ccaatttctc acaatcaaaa gcgatatcct ttaaagggcc gaaatcttca attccaactg 3348901 tatccagatg ggcatggtaa atgactgtat ttcggctttc tccatgtcct ttaataaacg 3348961 caaaaatatt tttgcgtttg tatgggtcat tgggaatggc ctgttcccac acatgactgg 3349021 ggttttcctg aaaataagga tagctcgtga tcacttcttt gatgaaatct gcttttgtcc 3349081 cttctccaac ggtgccgttc acgctgctga ggctgaccag agatgctgtc agcgcctcca 3349141 ctctttcagc cggattcatg tgactgattt ttgtatactg cataaattgt cctcctgatc 3349201 aaaaagttga aatcgtgcga tccgctaaag aatcgcacga ttttatttct ctcaaatcaa 3349261 aaagcttcgg acgttgtttt ggcttgcata tgaagaatta agtaatcggg accgcctgct 3349321 tttgagtctg ttcctgacat attaaaaccg ccgaacggct gatagccgac aattgctccg 3349381 gtacatcctc tgttaaaata taggtttccg acatggaaat cctcgcgcgc ccgttcaatg 3349441 tgcgcacggt ttttcgtcag aagcgcacct gttaatccgt attccgtgtt attggcaatc 3349501 tccagcatat gatcgaaatc acgcgctttg caaatcgcaa caaccgggcc gaaaatttct 3349561 tcctgcatca agcgggcgtt ttcatcaaca tctgcaaaga tcgtcggctg aataaagtag 3349621 ccttttgaat catcgccttc tccgccggcc aatagcttgc cttcagattt gccgatttca 3349681 atgtatttca tcactttgtt gtaggatgct tcatgaatca cgggacccat atacgtatca 3349741 ggatcttctg gattgccgac agtcagcgtt ttggtcagcg ccacagcttt ttccaccact 3349801 tcatcataca catcctgatg aatgaccgcg cgggagcccg cagaacactt ctgtcctgaa 3349861 tatccaaatg ctgaatacac gatagaggat gcagcaaggt caagatcagc gtccttgtcg 3349921 acaagcactg tgtcttttcc gcccatttct gcaattaccc gtttgagcca tttttggccc 3349981 ggctgcactt tggcagctcg ctcataaatc cggcagccga ctgcacggga acctgtaaat 3350041 gagacaaacc gtgtcttcgg atgctcaact aagaaatcac cgatctccgc accatctccc 3350101 ggaatgtaat tcagaacgcc gtttggcaga cccgcttcct ccatgacctc gacaaatttt 3350161 gctgccacta ccggggctgc gtcagccggt tttaagagaa tcgtatttcc tgtcacaatc 3350221 gctgccaccg ctgttcccgc cataatcgcg agcgggaagt taaatggaga aatgacgatg 3350281 ccgacgccaa gcgcttcgta atgatattga ttgacctcgc cagcacggct cttcaccgga 3350341 gccccttcct tgagctttaa catttggcgc gcgtagaact ctaaaaagtc tatcgcttca 3350401 gccgtgtccg catctgcttc cttccacggt tttcctgctt ccttcacaag atagcttgaa 3350461 aattcatgct ttcttctgcg caaaatagcc gctgccttaa agagaatatt tgcgcggtgc 3350521 tccggtcttt gttttttcca ggaatcaaat gcctgcaatg cggcttgcat cgctttttca 3350581 gcaagctctt gatccgctgt agacgcgtac ccaatgatct cttctttatt tgccgggtta 3350641 atagaaatga ttttgcggtc cgtttcaatt ttttctccat ttatgacaag cggataatgc 3350701 ttgccgagct gagtgtttac aaaggccaat gactccccaa atgcagtttt attctttgct 3350761 tccgtaaaat cggtaaatgg ttcgtgcgcg tatgtgactg tcatatgtag tccccctcgt 3350821 gttatgaaat atatcttcgc atatgaataa aaatgcaaga atcatgccat tttcttgtct 3350881 tttgctgaaa aaacttgttg aatcgaacag aaatttgtct aacaggtgat cacctttctc 3350941 tttttccgat cttgaacgca aatttatttt gcgttttttg ctctttacgc aaaaaacaaa 3351001 tgcaaaatta ttttgcggag gcttctcaaa ttagacccat ccgcggaaac gcgatgcttc 3351061 tgccgatttt ctgatgcccg tcatgtaagc cgccaaacgc atatccactt tatgtgttgc 3351121 cgctgtttga taaattgttt cgaacgagct gaccatgacg cttctcagtt tttctgcaac 3351181 ctcttcttcc gaccaataat atccttggtt gttttgcacc cattcaaaat aagaaaccgt 3351241 gacgccgccg gcactcgcta ggatatccgg cacaagcagc acgcctcttt cattcaggat 3351301 cttagtggca tcaatggttg tcgggccgtt cgccgcttca acgacgattg acgcctgaat 3351361 gttatgtgcg tttttggctg tgatttgatt ggagatcgcg gcaggcacta aaatatcgca 3351421 atccttttca agcagctcct catttgtgat gacgtcagta aataaattgg tgaccatacc 3351481 aaagctgtcc cgtttatcga gcaaataagg gatatcaagg ccgtctgggt tgtagagccc 3351541 gccattggca tcagaaatcc cgatcacctt cgcgcccgca tcgtgcatga atttggccag 3351601 gaagctaccc gcgtttccaa agccctgtat gatgatgcgc gcgttttgca gcttgatccc 3351661 ttttttcttc accgcctctt caatacaaat cgtgacgccc tgtgccgtcg ctgtttcccg 3351721 tccttgcgat cctcccaaaa caagcggttt acctgtaata aagcccggag aatcgaattc 3351781 ccgcagccgg ctgtactcat ccatcatcca cgccataatc tgcgaattgg tgtacacatc 3351841 gggagctgga atatcctttg tcggaccgac gatctggctg atggcacgga cataccccct 3351901 gctcagcctt tccagttctc caaatgacat tgtccgcgga tcacaaataa taccgccctt 3351961 cccgccgccg taaggaagat tggcaatccc gcatttgagc gtcatccaaa tggataatgc 3352021 ctttacttcc tcttcattaa cttctggatg gaagcgaacg cccccctttg tcggaccgac 3352081 agcatcattg tgctgtgacc ggtagcctgt gaacactttg acgctcccat tgtccatttt 3352141 gaccggaatg cggacagtga gcattctctg cggctctttc atgagttcat acatatctcc 3352201 cggataaccc agcttccgaa gggcttcctt aatgattgtt tgggtagaca gaaataagtt 3352261 aagagcttct ttttcttcat ctttcgagac ttgctttgct gacatctttt tcacctcatt 3352321 gtttttttgg ccggctgtaa tgtaagcgct ttaaaaaatc agcccgccaa ttcctttctt 3352381 cattggattc acccttatca tcatgcaaga tccgtaccag cttttgaatc cacaaaaaaa 3352441 gagactgaaa acatctcagt ctctgactac aaatctatcg attaacgggg atcaatcacc 3352501 agctgcgttt cagcataaaa actgccgatt cccaaaccgt ttactacatc gcctttaatc 3352561 gtgtaagtgc ctgcgcgagg aagagtttta cgcaccatga caaggtcaaa ttcggatgcg 3352621 cctaacaaat caagcgtaag cgggagtctg actgtttttc catcgtttaa aatctgtgtt 3352681 tctttcagtg ttcttccatt cactgaatct cttgtcgtag catgaaaccc gtcaggaaat 3352741 tgaaattcta ccgctccaag agaaagcacc gcatttggtt tatatgtcac ttcaatatca 3352801 gaaatggtcc actctttcgt gctgttaact gtttttgcct cgattgatgc agactgtgca 3352861 tgagcttggc ccgaaggaag taagattgat agtaaaacag ctgaactgat gaataatgaa 3352921 gatacgaatg aagttctttt tagcatgaca tttcccccta attgattgtt gaaatttggc 3352981 cagagcgtcc tctgcagaaa aagcgctttt tcataattcg cgaattacca gttctttttc 3353041 ttaaaaatta atctatcatc attttccatg gaagtaaatg ttttttaagg aatattaaca 3353101 cttggaattc aatgagaatt ccttcctgtt tatacaaggt tcaaatggac gatttccctc 3353161 tctttttcta gtaacatctg cctgacattt tatatctttt atcctatttt aaaaaagggc 3353221 aaaaaaagtc gaagatgcct ctgctcttcg attgatcacg ttcctatttt tatctgaatt 3353281 cagtgttcca gttaaaaccg atcgtctcat catcccacgg aattcttttt tcatcaggct 3353341 gatccgggtt atacgacatg gtggtaaaat agataattgt cagcggcgtc tctcccagca 3353401 ctctatatcc gtgagccacc ccttttggga ttaataacag catcgggttg tcttcgccca 3353461 tataatagac gtccgtttct ccttttgtct ttgaatcctc tcgaagatcg tataggacaa 3353521 cctgagcgtg gccggttggg aagaaccaga gatcatcctg cttctcatga taatgaaatg 3353581 ccttaatcac acccggatag cttttcgacc aagaggcctg cccaaaatgc tcaaggagat 3353641 tctcatcgtc ccggaccagc tcagcaaaaa agcctctgtc atcgctatgc ttcatcaatt 3353701 ttttcacctt gactccatca atcacacgca ctgctccttt cctgcaaata ctctcgtaac 3353761 gcttcccgcc agtggcgggg gcggatgccg gcttcttcaa tagcccgatg gctcagcaca 3353821 gagtatgccg gacggggcgt tttgttcccg tattcctctg tcgttacaga caaaatggct 3353881 gtttccagcc cgctttcttc cataattgcc gtcgcaaact cataccagct gcatatgcct 3353941 gaattgctga catgatagat gcccggcgga tggctgaaca gcttgatgac cgcttctgct 3354001 aaatccttcg tataagtcgg cgaaccaatt tgatcgctga caacccgaag ctcttgtttc 3354061 gtttcagcaa gtttcagcat ggtttcaacg aaattactgc cgccatgtcc gtacacccac 3354121 gatgtcctga tgatcgtgct gtcttttgtc gttaatcgta tcagttcttc tccgagcctt 3354181 ttgcttttgc cataaatggt tttcggatcg aggggatcgt cttccctata tggctgggtt 3354241 cctttcccat tgaatacata gtccgtgctg atatgaacat attgagctcc gatgcgggtt 3354301 gactcaagcg ctgtataata agcgccgatt ccgttaatca agtacgcttt atcaagctct 3354361 ttctcgcatt gatcaaccga cgtaaacgcg gcgctattga ccacgatatc cggctgataa 3354421 tggccaaacg aatgccgtac tgagcgctgg tcagcaatgt tcatcatctt ctttgttaac 3354481 gcaatgacct catatccggc ttgcttcagc tggcggcata gttccaagcc aagctgtcct 3354541 cccgccccag tcaccaatac ctttgtcaat cagatcacct tctcatcggt cattgtctgt 3354601 ataccactga atcgtacgcg caatgccttc ttcaaacgtc acttcctgcc gccagcccag 3354661 ttcgtttttc agctttgatg cattgatcgc atagcgccgg tcatgccctt ttcggtcttc 3354721 cacgtgggcg aacaattcct cacagcccag atgcttcaaa atgacactcg ccagctcttt 3354781 attcgtgcgt tcatttccgc cgccgatgtt atacacctcg ccgtcggtcc ctttttctaa 3354841 aatcagcttg atcgcgcggc aatgatcctc cgcaaacagc cagtctcgga tctggagtcc 3354901 atcgccatac agcggaacag gcaggccctg cttcgcatga cggataatcg tcggaatcat 3354961 tttttcgctg tgctgataag gtccgtaatt gttgctgcat cgtgtaatga tggccggaag 3355021 cttgtgggtt ttcacataag acaacacgag caaatcagag cttgctttgc tggctgagta 3355081 tgggttatta ggagaaagcg gcgtcgtttc tgtaaacgcg ggatcatccg cttttaaatc 3355141 cccgtatacc tcatctgttg aaatatgaat cagcttcttg gcttttcctt tcaagaccgc 3355201 ttccgccaat cggtatgtcc ccatgacatt tgtggtgata aacggctccg cttgggaaat 3355261 gcttctgtcc acatgcgatt ctgctgcgaa gtgaatgacg ccatcgtagg tctcgtcaaa 3355321 agcgcggtcg atatcctcct gaacgctgat gtcccctttt acaaagcgaa aacggctgtt 3355381 ttgctttaat ttttccattt cctccgggtg gctggcgtac gtcagtttat ctaaaacggt 3355441 aatgcgcgca tccgtttccc tcagcatgag ctttgtaaac gtgagcccga tgaagccggc 3355501 cccgcctgta attaaatatg attttgccat cacttttcgt cctgtccttt ccgtaaagcc 3355561 tggtgtacaa gctgggaagc gagataaagc gattcgtgag ttccggcatc tacccaccag 3355621 cctgataaca catcatacgt aagctggctg ttttcgatgt atagattatt cacatcggtg 3355681 atttccagct cgccgcgctt tgatggtgat atttgttcaa tatatgaaaa cacctctgca 3355741 tcatacatat aaatgccggt aacacaaagg ttggtcggtg gctgttcggg cttttcgatg 3355801 atggaacgaa tccgcttgtt tttctcatca atctcagcaa tcccgaaacg ttccgggtca 3355861 tcaacttctt tcagaagcac ttttgctcct ttcccctgct gttcaaagcg ttctgtataa 3355921 ggctttaatg aatcttcaaa tatattatca cctaataata aaatgaaaga ctcttttttc 3355981 gtaaagcgct ttgcataaga cagcccatcc gaaatgcccg atgctgccgg ctgtacttga 3356041 taagtgatag taacgccaag ctcttccccg ttcccaagca gtttgtaaaa ttgcggcata 3356101 tgctcctttt ggctgatgag taaaatgtct tttattccgg cttcctgcag cttcataatc 3356161 gaccagtata tcatcggata cgggcctaca ggaagcaaat gcttgttgac ggctttcgtt 3356221 aagggcataa ggcgtgagcc gtttcctccg gctaaaataa cacctttcac attaacactt 3356281 ccttacatgc atttttatat ctcttgttca tataaatctt gaagaatagc tgttacccgt 3356341 ataatgcctt tgccatccac gagcggcctt cctcccttgt gcaaagaaag gcgaagagga 3356401 tagctgctca taatgcgtga catctgatag atgagtgttt catccggtac aagctcaccc 3356461 aatccaagat caagagcggc gccttggtca gcaaatgttt tggctgtagc cgtttgatgc 3356521 tcaacctgag aaagaacaag gcacggcacg ccgatgcaaa tggcttcata tagagagatg 3356581 ccgccagcga caatggctgc gtccgcttgt ttcatcaaac ctgccatatc atttgtctgt 3356641 tcgatcatct tgtactgcgg cttcttttcg atccgccttc ggactgcctc ttgatgcggt 3356701 gaagcgctcc ccatcacaaa catcatgttt ttgtctttta tgtcggggac ttgatcagcg 3356761 gcagccagca ctttaaaaat aagctgcttc ggatcacttc ctcctaatgc aacaaggata 3356821 ttgcggcagt ctttcttaag tgtgtaatcc tctcttgcgg cctgaaaggc ggggtgaaga 3356881 ataagatagt ccggaccttc atagatgcgt gtgtttccct gaacgtacac cctgcttctg 3356941 atgtcaccgt aaattccgtt aatgactgcg tcactatatt gaatcgattt accgtttttc 3357001 tcttcaaaaa gaacaatttt cgcatctgtc tccgtcttta ttttctttaa cagctctgca 3357061 ggcgcgccta gaatatcaaa caaaagcaaa tcaagcttct tgctttttat ttcccggaga 3357121 ataaattcgt gctgctgcag ctccggcttt acgatgacct gccaatgctc ttcatgaaga 3357181 aacgcttcag aatcctgatt cgtataaaac gtaatcaagc atcgctgttt gagcccctcc 3357241 gcaagcctct tcatccggac aacatggccc attccctttt catagccgcc gtctgcgaag 3357301 atcccaacat gcatggctag tcagcctctc gttcggttgc cgcatcgggg ttccggttca 3357361 gaagggtgat aagctctgag gcggatacat cggggcgctc gcctgctttt tgatagaggg 3357421 cctttatcga ttcatagtct tcctttgtat caatggtcag ccgatattga ggggcgcgaa 3357481 atcgttccgg cgcctctaaa aactgaacac gataaagagc tggatgattc cttatatata 3357541 acgtgacatg ctcctgatat tgatcctcca aagcctgaat acggctgatg tcaattaaca 3357601 ggttggcgtt gaccacttcg ccgcaaatcc ctaatggggc attcaggata tacgtataat 3357661 ccgagccttg atcaaaatgc gcctgaatca ttacatcgag cagctcagga tcgacaaacg 3357721 gattatcacc tgttaaccgg atgatgactg acggtttaac agcttctatg accttcacaa 3357781 acctatcgag gacacgttct tcgctcccgc ggaaaacacg aaagccttgt ttgatacagt 3357841 gcgcctctaa tatgtcgtca gtttctttgt cagacgtggc gatgacaaga ttatcccgat 3357901 ccttttggta aaacgcgctt tgccggacac ggtgaacgag aatatcaagt aaacgattcg 3357961 atccgagcgg ccgaagcact tttcccggaa gccttgttga acccattctt gcttgaatga 3358021 taaagagaat atcattcatg aaacgggctg tccttcagta aaatgtcatc ccagacaatg 3358081 cctgtgtcgg ctggaatgtc tcttacagcc cgaacaccgc tggtcagcag ttcaaaaaat 3358141 ctcgggtgca gcccctgcgg cttttgtccg ggccgaagca ctgcgatatt gtcttcacta 3358201 aaggcttcac ctttttgaat cggagctgtt gtaaaaatgc ctctgtatgc aaagtttctg 3358261 atttctcctt cgatggcggt cgttgttttg tatgaactgc caagcagttt ttcagagacc 3358321 ggctttgtga tcccctgttt cagctcagct tccgttttcc tgatgccatc gaccatttct 3358381 ttcaattcat ccggatttaa tgcaaacgag tggtcagcac ccggcagatt tttatcgatc 3358441 gtaaaatgct tttctatcag ttttgctccg agccgaaccg cggcacacgg cgcttctgtc 3358501 ggatgctcgc tatgatcgga gaagccgatt accgcctcag gaaaagcggc ggcaagcatc 3358561 ggaatgacgc tgaggttgct gtactccggc ggtgctgggt atttcgccac acaatgcatt 3358621 atggcaattt gattgtttcc ctctgccctg atggtgcgcc aagcttcgtg aacatcagag 3358681 atttcagctc cggctgtcga gaaaatcatc ggcctgttca gccgggcgac atatttaagc 3358741 agcgggagat ggttaatttc ataggatgcg attttaaaag cgctcggcga ggtagactga 3358801 agcagatcag ctgacccctc gtcacatacc gtacttaaaa agatcacctg cttttcgcgg 3358861 cagtaatcca atagcggtaa aatccactca gcaggcattt ccatagattg aaccaaagaa 3358921 aaaatagaga cgtccttgcc cgctgccgtc ttgtacaaac caggatcttt ctggtacatc 3358981 ctatcagctt ggaacatttg aaatttcacg gcatccgctc ccgcttccgc cgcggcgtct 3359041 atcagcgcaa aagcctgatc aagcttcccg tcatgattaa tccccgcctc agcaataata 3359101 aaaacaggag cgtctttgcc tacagtttta ttcgcgatct gaaacgctgc cattatttcg 3359161 cctccttgcc cggccaaata tgataatagt aatacgattg ttcagcggtg aagcccattc 3359221 gttcataaag gcggatcgcc cttacattgt gaagctgcgt ccccgctgtt accgttctat 3359281 gcttctgggt ctccggttgt tctatgagat tcgccaataa atgaaacgca atacgtttcc 3359341 cttcaaatcc cggctttaca gccatcaaat cgagaatgca ctcatcatct cttgataagc 3359401 cctgaagata gccgatgacc tcgccattgt gtttagcgac aatattgacc gccgcccttc 3359461 cattcagatt gtttcgtgtc cactcctgaa atatttcgtt tgctgcatcg cggctgagat 3359521 gaggatcctg aaaatatctg ctttttgtaa acgagtctcg ggccagctca catatcgctt 3359581 ctgtgtctcc gggctcaggc gggcccagtt caaaaaatgg cggtgttttg tcataaaaag 3359641 acggaggcat cgccagcttc agcaaactcc cgacaaagta agaggatggc tgctgttgta 3359701 tcacatgcgc ggctccgata tcttcagccg gaacacggac aaagataaaa tccgtttcat 3359761 ccatttggcg tacagtataa aaagcttcaa acagcctctt tagctgcccg gtactatttg 3359821 ccgcaagaag tttgacgttc atgactttct tctgaagcac cttgctttcc cacaaagaat 3359881 cttcgtaaag caatacgcct tggagcctgc tgttttcaaa aaggccgagg gaaaattgat 3359941 acggaacatc caatgtaagc tttctgcttt ggagaaattc ctcaattgcc tctttggaga 3360001 cattttcttt taccgtatac acttaatcag ccccttttac gatatcccgc acagcttcaa 3360061 tgacatcatc tacatcatcg tcagacattg atggatagag cgggagagaa agggttcgtt 3360121 tatagtaatt catggcattc ggaaagtccg cttccttata tccaaattgc ttttgataat 3360181 acggatgaat gtgtactgga ataaaatgaa cgctagtgcc gatattgtat tcatccttta 3360241 aagccgtaat catttcgctg cgcgtaaccc cggccttttt ttcatcaact tgcagaacat 3360301 atagatgcca ggcgtgcctg ccgtcatcat ggacaaacgg cgtgatcagc ccaggaatct 3360361 gctgaaaagc ggtttgatag cggccggcaa tctcttctct ccgtttctgc atatcatcca 3360421 gccgtttcag ctgatgaagt ccgagggccg cctgcaaatc aaacatattc atcttatagc 3360481 cgggcgattc gacttcatag taccagctgc catttgaaga ataacggttc catgcggctt 3360541 tactcatgcc gtgaaggctt agcacccgta tcttatcggc aagctcctca tcatcagtcg 3360601 tcagcatgcc gccttcccct gtcgcgaggt ttttggtggc gtaaaagctg aatgccgttg 3360661 catccccgat agaaccgatc attctttgct tataagtcgt atataccgca tgtgccgcat 3360721 cctccagcac gaataaacca tgattttggg caacagccaa tattgcatcc atatcgcagg 3360781 actgcccgcc aaagtggacg ggcacaactg ctttcgttcg cggtgtgacg gccgcctcaa 3360841 gctttaccgg gtcaatattg agcgtgtttt cgtcaatatc cgcaaacaca ggcgtcgctc 3360901 ccgtatgaat aatcgtattg gcggtcgagc tgaacgtaag cggagaggta atgacctcgt 3360961 ccccgggccc aatccctttt gctttcaaag ccaaaaataa agctgcggta catgaattca 3361021 ccgccacggc gtgcttcgcc ccgacaaacg cggcaaactc tttttcaaac tgctgaacct 3361081 tcgggccttt agagagccat cccgattcaa gcgtttctgt aacctcctga atttcttcct 3361141 taccgattaa cggcaatgag taagggagaa aatgatttct cttttgcacc atttctttgc 3361201 gctcctatca ttttattcag tatcttcccg cctgtaatca acccctgttt tggctttcag 3361261 ttccgcaaat aaagcatttg ttgattctgc caccggataa ttagccgcta tgaatgccag 3361321 gcgcgcctct tctgcttttt gatgcacgtc gggacttcga agaacctcaa ccaaggtgtg 3361381 cgccagttca tccggctggt caaacataaa atcgccaaga gactcataat acggatacga 3361441 gcgatttccg gacgattttc ctatcagcac aggcttttga aacagcatgg cttcaagacc 3361501 gactgtcgag gtttgcgtca ctgcggcatc aacatacggc agcaaatcat aaagctccag 3361561 ctcctttttg atgactctgc atgcttgatg ttttttcgcc gcctcgtgat acagatcaag 3361621 cttgtttttt ccgatttccc acgggtgggg tttgataatg atttgcagct gcttctgatc 3361681 agaaagcccc tgcagcacac cggaataaaa gtcttctgaa aagggctgag tggcaatgag 3361741 cacaattttt ttagtcggct gaaaagcaag ttttcgatag aatatggaca tatccatagg 3361801 cgttctgtta aaaatctgat cgaagcgggg atgtcccgtt acgagaatct gctcgggttt 3361861 acagcctttt cgtatgaacc actctgcttc atacgcacca aaaacagctt gataggttgt 3361921 aaaaacagga atgaaggctt catctcccat caatgcgcca tgctgaagac aaatgctgac 3361981 ggcccctttt ctttgacaca tgagagcgag caccctgctg taaatgtctt ctgccgttcc 3362041 gacaataaca gctgaaatct tttcctgttc aaacagcgca tcaactgtat caatggcctc 3362101 tataaataaa ggaatatctt tgaaaagccg gtcgcgaaac gcttgatcac caaatgccgg 3362161 gtgatcatca taaggggcga gaagcgaaca ggctgtttcg agatactgct tcgaatcgcc 3362221 tttttggcat gaatccgcaa tctcccgctt gctaattaca ggcagatcac aataatgcgg 3362281 caaactccat ctggccaaaa cagccgtttt ttcaggatca aattgatagt aattttcgtt 3362341 tgaaaaacgc aggtaatcaa agtgcaaaat gactttccct ttaacaggtt cgtcatttgt 3362401 tttaacgatg ttttggattc tttcttcaaa aaacggctga atctgtccct catcgatatg 3362461 ctgatccacc gatccgaata attccggttc ttcttccatc atcaccctca gttcagggct 3362521 gatgtattga taaaaattac tgataagccc aagcggaatc cctttgtagc gaagtttgtc 3362581 aaaaagctcc acgtacttcc ggtacagcac ccaataattg cttaaatagg ccgacaagct 3362641 ctcaccccat tccaagcttt tttaatgatt cacgcagctc tcggcaattt cgctgcggag 3362701 gaaggttcct gacaaattca tttttttcta attcaaacag ctgaaagtga atcgattggt 3362761 cggtaatata attcaggtcc agctcctcat ccagtgggta aaacggataa aaatgattga 3362821 ctctccaaaa gaaccgggca tctcctatac ggtaaaacgc cgggctttca tcccaatagg 3362881 agccaaactt ctcctttacc ttctcaagca ccgaatacct gtgcatcacc gagcaatgat 3362941 caattgcgca cggcgcgttc catgtcactt gagcggcagg cctgacagtt tcttttacaa 3363001 tgtcacgatt ctcgtttaaa tgataggttt tggaggctga gtaaatcaca gccttttcag 3363061 gatgggtatc gagctcccgc accattttca ggaggcggtc cggcatatag atgttgtcat 3363121 ccgtcgcata ggtgatatat tcaccctccg ccatctcaat cgcctgattg atcagtgccg 3363181 cgtatctcgt tttttctgtt ctttccttca ctccagatat atcgctttga taaaaacgca 3363241 ctcggttatc attcaaaaaa ggacggatta cattcagcgt ctcttcattg gagttgtcat 3363301 ccataataaa caattcaaaa tctgaaaacg tttgtgagag tatgctagaa atggactttg 3363361 ccacataatc gcttttgtta tagctcgtca taatgactga tactttaggc aaatcctaca 3363421 cctccttctt ggaacttcac acctgaaact atcgttatct tatgttgctt atgctcaagt 3363481 tgcgctaggg atacaaacca atatgcgaaa agtttgtgta tgtttctgaa aaacagcggc 3363541 tgcccagagc gaaatctgat cggtccgctg ttctttttca gcataatcca agcatcagcc 3363601 tcataaggtg aaagagataa aaatcgcacc agcgactaag atcgttttcc atcggaggtg 3363661 agtcatcgcg gagcgttcac ctatacatcc agaacatgtt ttgaatggtt ttcataaaaa 3363721 ggaggaacga tatgaaaccg aaaaaaaatc aatatcagca aatgcaggca tttgataata 3363781 tgcaggggta tcagcctcag tttggcgcca acccgtaccc gcagcaaggc caaggctcac 3363841 aaatgcagac aatggggatg cagccaatga tgccaatgca gcagggacag caaggacaac 3363901 aaggacagca gggatttgga ttcccgggcc agcagcaggg cggcggtttt caaattccat 3363961 cggggcctac accgtcagga ccgggccaaa gcgttcccgg catgctgcct gttgaggaat 3364021 cttacatcga gaatattttg cgcctgaatc ggggaaaaac ggccaccatt tatatgacat 3364081 ttgaaaacag caaggaatgg ggctcgaaga tttttcgcgg cgtcatcgaa gctgcgggcc 3364141 gggatcacat tattatcagc gacccgaaat caggaacacg ctacctgctc ctgacaatct 3364201 acctcgatta cattacattt gatgaagaaa ttgcttatac gtatccatat tccatggcgt 3364261 cctattcgcc aagataagaa aaaagccaat cactcatatg atgaggattg gcttttttgt 3364321 ttatagatat ttgacggctg cgacaacgat cataatccaa gaaataataa acgccacacc 3364381 gccgagcggg gtgatcgctc caagaatgga gatttgcgtc acacttagaa tatataagct 3364441 tccggaaaac agcacaattc ccgcaaacat cagccagccg gctgtcgtga cactgcctat 3364501 gccggataat ttatcagcca gaaacgcgac aacgaataac ccaagggcgt gatacatatg 3364561 atactgcacg cctgtgtgcc aaacctgaag atacttatca ggtattttcc cttctaatcc 3364621 gtgagcgccg aatgctccga gtcccacggc aagcagggcg ttaatggccc ctaatatgat 3364681 aaaaactttc atctatctct cccgcctttt cgttaaactc atatcattta tcttatcgca 3364741 cctgcaccaa aattcaatgt ttgttctccg ttgacacgag attgtcggat tttctcctgc 3364801 gccaaagctg gaactggtca gctgctattg cagcaagcgt ccctaatacg agcccgttgc 3364861 ttaatagaga aataaatacc ggatgcaatc cctttaacgc agtttcagga acaaacatga 3364921 taccgacccc tgtcagcagt gagataccga tgatagacct cacccttttt gattcttctt 3364981 tctcatatga atcaaattcg gcaaaggcca gaccgcccat tgcggagaac acaacaaaat 3365041 tcaccgcaaa tccaacgggt gacggcaggc tcgcaaacgt attcataaaa aacgggatca 3365101 cgctgatcac gataaccaga atactgccga gcataaacgg ttttttagaa ggcatcttgg 3365161 tcgtttcaat aaaacctgcg gctcccgaaa tcggaacagg cgcaatagct cccgtcaaac 3365221 cgctaagcag atggctgaat gaagctgcaa aaccggcatg gcgttcatga tgctttccat 3365281 caggctgttt gctgaatttt ttcatggcga tgtccacgac cttcatgctc gccagcatat 3365341 tcacgatcag caagatggta ataaaaatag aagtgatgat caggccgctg ttaaataacg 3365401 gggtcccaaa aggaaacagg gaaggcagct gaaacagccg gtccggcatt tcaatcggct 3365461 ttgcggctcc ggcagccgca aacagcaccc acccgccgaa caaggctaat aaaatagaat 3365521 attgcttaaa aaacatgatg ttcgaatttg tcattataaa agcggcagcg atcacaacaa 3365581 gcgccaggcc aaatacaaga ccgtccaccc cgtcctgtcg ataaccgatt ccgagaattc 3365641 cttttataat gggctgactc agctgcatga caagaagcaa taaatagacg cccgttacaa 3365701 ccggagtaaa caattttgca agtctgtcaa tgaccttgaa aacacttaac aaaaagaaac 3365761 atacagcgct tacaagaaga gctccctgca aaccccgcag tgtgtctcca tatgtcgcaa 3365821 acacagttcc cgtcagccct gcgtaaatcg tatacactcc ccaccacaag ccggctgggc 3365881 tttcattgat cggcagtctg tggcctttca aacactgaat gacggcggca attcccagta 3365941 caaaaaaagt gctttgaatc aatcttgcag aatctgagtg atccagatga aacgactggg 3366001 caaccgccac cggaacaaca atcgccgcag caataataaa cgctgtccat tgcagcgcgc 3366061 caagaaccaa tttcacgtaa gctcaacctc tctctttaaa aatcaaataa agactctccg 3366121 tttccatcct cttcctgctt ctctttttct tgctttcgat atttgtttaa tcccgcgctc 3366181 cccatcattt tttccatcat cagctggtct gtcgatggcg gcgcggcggg acttggcgta 3366241 acgctcggct gtatgcgggg cgcgctcgcg ttctccggct gatcaagcac gacatcacac 3366301 agagaacgga caaccgctac ataacgcttc agctcctcat cccgttcagc cgtttttgct 3366361 ttttttagct cttcttccat cttttgaatc aaagcagata tatgaatgtt catgaagcac 3366421 cctccaaaaa aataaatgtt gtcttcctgc attttatcaa attcctgctg aaaacgcaga 3366481 tatgagtttg ttattttttc tgacaaacct tgcgcgattg acaagcagaa gagatttttc 3366541 acataataaa tcaccatacc ttacaaaaag gagaaacgga atgaacagca tcccctctat 3366601 catcagcaag cataaagcct attttgcggc gggacatacg agaccgcttg aatcgagact 3366661 gaacattttg cgaaagctga aacaagccgt cagaactcat gaagccgatc tcatagccgc 3366721 tctctaccag gatctccata aatccgagca agaagcatac tcaacagaaa tcggaatcgt 3366781 cttggaggaa atcagctttg tcatgaaacg gctgagaaaa tggtccaagc cgaaacgagt 3366841 caaaacgccg ttgactcatc taggctccaa aagcatcatc atccctgagc cgtatggaac 3366901 cgttttggtg attgcgcctt ggaactatcc cttgcagctg gcgctttctc cgttgattgg 3366961 cgccattgcg gcggggaaca cggtcgttct caagccatca gaatatacgc cggctgtttc 3367021 tgctattctt tccaaactca tcagcagcgt ttttccaact gattatgtcg ctatggcaga 3367081 aggcgggccc gatgtcagca cagcattatt acagcagccc tttgactaca ttttctttac 3367141 cggcagtgta gctgtaggaa aaatcgtcat ggaggccgcc gccaaacaat taattcccgt 3367201 aaccttggag ctcggcggca aaagtccctg catcgtccat aaagatgctg acattcagct 3367261 tgccgccaaa cgcatcgtct tcgggaaatt tacaaatgcg ggacaaacct gcatcgcacc 3367321 ggattattta tttgtccacg aggacatcaa aacgaagctc acagaagaaa tgaagcgtgc 3367381 gatcagagaa ttttacggcc ctcagccgga acggaatcca cagtacggca aaatcgtcag 3367441 tgagcgccac tatcagcggc tgctcagctt tctgaatgat ggcatcccgc tcacaggcgg 3367501 acaatctgat cccaatcatc acaaaattgc gccgaccatt ctcgaacaag tgagagatga 3367561 ctctccagtg atgcaggagg agattttcgg gccgattctt ccgctcttta cataccgcaa 3367621 tatcggggaa gtcattgaga aagtccaatc gcgccctaag ccgctcgccc tgtatctctt 3367681 caccacaaac aaagaaattg agcgcgctgt tttaggaaat ctgtcgtttg gcgggggctg 3367741 tgtcaatgat acgttaatgc atgttgcgac gccgtatttg ccattcggcg gcgtcgggga 3367801 aagcggcatc ggcagctatc acgggtttga cagttttaac acattcacgc acaaaaaaag 3367861 cgtcgtcaaa caaacgaacc gtttcgactt cgcatttcgt tatccttcct ccaaaaacgg 3367921 gctgcgaatg attcgaaaaa tactcaaata aaaaagcgca gatcacctgc gctttttaca 3367981 aatccttaat acaccaatca atcggcgcct ctcccatttt ctccaaatag gcattcgccc 3368041 gggaaaacgg tctgctcccg aaaaatccgt ttctcgcaga aaacgggctg ggatgcgtcg 3368101 attcaatgat aaaatgcttg gaggtgtcga tccgttcttt tttcatttga gcatgccgtc 3368161 cccacaaaat aaagataacc ggccgctctc tttcactcag cacgtcaata attcggtccg 3368221 tcagtcgctc ccagcctttt cccttatggg aattcgcctg tccgcgcctt actgtcagca 3368281 cagtattcag caaaagaacg ccttgctttg cccagctcac aagcgacccg tgattcggga 3368341 tgctgcaccc gatgtcctgc tgcagctcaa gaaagatatt ttttaacgaa ggcggctgct 3368401 ttacaccggg cttgacagag aagcttaaac cttgagcctg tcccggcccg tgatacggat 3368461 cttgacccaa aatgacgacc ttgacatcat catatgatgt ataatgcagc gcgttgaaaa 3368521 tatcccggct gtccggataa atcgtttgct ccgcgtattc cctcttcagc atctctctga 3368581 gctcttgata atacggtttc tcaaactctt cctttagctg attccaccag ctgtcttgta 3368641 aaagctgttt caagattcag gcctccttac gaacgatgaa gtctggaata gacaggctcg 3368701 ccatcccaaa ccatttcact ttttgcttcc cgcctcttca tctcaggctc ttcaagcagg 3368761 acggcaaagt ttttcgtcgg cagctccccg agtccgtgct tttcacttaa acgatccaaa 3368821 tattgcttcc gcttggcgcc aaggtcagca gactgattgt ctcccgcgtc actgaaggca 3368881 taaatcacgc tggcgcaagg gacacgcttc acccggtaat ccttggccgc gcgcaaataa 3368941 aaatcccagt cccagtaatt gtgcacatca gcatcgaaat acccgatttc atcatgcaga 3369001 aaacgtctgt acatgctgcc cgacggcacg tatgtagaaa acactctcat atcctcatag 3369061 tcagcggtat aagcaaacaa tttccgtgac actggatacc ttgttccgtt tttctcttca 3369121 aacgaaacta tttccgcatc agaatgaacg aagtctgccg tttctatttc ctttgccatt 3369181 ttctcgatat gccctggcgt aaagaaatca tcgtcatcac acagcataat gcaatcccca 3369241 gacgcctctt ttacaccggc atttctcgca gccacatgcc ccgagttctt ttctaaattg 3369301 atgacagcaa tcggcagctc cggataaagt gctttgaccg gcacgaccga ttccccggca 3369361 tcattcacaa taataatttc atacggcatc aaggtctggc gggaaatcga ctccaaaagc 3369421 tcacacaaag ccggaatccg attataggtc acaattacga tagaaatctt catgatgctc 3369481 tccttctcat tttcatagtc atgtactatt aaaacatata ttggacggga gatcagtggg 3369541 aatatcctac tgaaacggca tactacaatg atagaaacag caaagtggct ccgatcagaa 3369601 gcaccatgat cagcatcaga tctccaaaga catgaaagat atctttcatg cggacgccat 3369661 tcggaaggat aagacgccac agcttagatt gatagaccgg cagcagcacc agtgcataag 3369721 aaagacacaa aaatgtaaaa gccggcggca caaaagcaca gcctgcatcg tcccaattca 3369781 tcatgatgtc tttcatacta gatccatcca ataaaaacaa agatatcatg agggctagca 3369841 acacaaagga ccccaattga acctcaaaca ggcgcatttt ctggttatat gcaaatcgga 3369901 ccgcccaaaa ccagacataa gcatatgaac atagcagcgt aagaatggca cctgctgtaa 3369961 agacgacatc aggcagccga tcaagcagaa aaacaaaagg caagctggct gccatagcca 3370021 agagcatgca gccaccagta aacaaaaata ctgccccatg agctacaaaa ccatataaac 3370081 aagagctaat cctcacgaca tacacctcct ttacatagaa attctatgta tatacctaaa 3370141 aaatcagaca agctgacgcc tgccaatata acagcccatt cggccaaata acggaaataa 3370201 cagcgttgca aaagcacaag ttccaacaaa ccaaggtgtc aacaaggatt gaaacagcgc 3370261 agcaggaatt acattgaata gaaaaacaag cataaaaatg acgtttggca ccattgagat 3370321 cagaatcgta tgtagaacaa gcttttctcc gcgttttcca aactccttca cgccttgata 3370381 cccaatcagc acccagtaga tcatatatgc agctaagatc agccaaacag aaacagaaat 3370441 gcctttccat actgcttgaa caaacggtga ttcaagccat acatgcatta ttgtaatcgc 3370501 aatgccgaca gcgaataggg cactgttaca gaaaagatgg aacatcaaaa acgcacgaaa 3370561 cgttactggc tgtattttct taaacgaaga aacaatgtca gttggtgttc caaacgcctg 3370621 caataaagtc tgcatagctt cctcctcact ctttccttcc tgaaaagagc gaaacagatg 3370681 atgttcaata tggctctcaa tctcttctat catcgcctca ccctcaggaa gccctttaag 3370741 cccgcttttg atttcggata catatgtttc tttatccatt ttgtccgctc cacttcagta 3370801 ttcggtccat catggctgaa aatacgctcc attccttcgt gcgttccgcc agcacttctt 3370861 tgccctcgtc tgtaatccgg taatatttgc ggtccggtcc tttctcctgc ttctcccagt 3370921 aggaagaaat atacccttgg cgttcaagct tgtgaagaga aggatacaag gtcccttctt 3370981 tcatctgcag ttcatttccg ctgcggcttc ccatttcttt tacaagctca tagccgtaca 3371041 tcggccgctc gttcagaagc gtcaatacca atataaccgt gcttccctta accagctcac 3371101 gatttaacat ctcaaaaccc ctacctagtt ttcttatgta gcattttacg aaagcccgtt 3371161 gagattgtca aatgattcct atagatcttc tatattgtga tacagagaaa atctaactat 3371221 aatgaaagac aaaacatgat ggaggttcaa gacatgtcta tgcataaagc actcaccatt 3371281 gccggctcag attccagcgg cggtgctggg attcaagctg atttaaaaac atttcaagaa 3371341 aaaaacgtat acgggatgac cgccttaacg gtgatcgttg cgatggaccc aaacaacagc 3371401 tggaaccatc aggtattccc gatcgatact gatacaatcc gcgcccagct tgcaacaatt 3371461 acggacggca tcggcgtgga cgccatgaaa acaggaatgc tgccaaccgt tgacattatc 3371521 gagcttgcgg caaaaacgat caaagaaaaa caattaaaaa atgtggtaat tgacccggtt 3371581 atggtttgca aaggtgctaa tgaagtcctt tatccggagc acgcccaagc cctgcgtgag 3371641 caattggctc cgctagccac tgtcattacg ccaaacttgt ttgaagccag ccagctcagc 3371701 ggcatggatg aactaaaaac agttgacgat atgatcgaag ccgcgaaaaa aattcacgca 3371761 ctcggcgctc aatatgtcgt cattacaggc ggaggcaaac tcaaacacga gaaagccgtt 3371821 gatgttctct atgacggaga aacagcggaa gtccttgaaa gcgaaatgat cgatacgcct 3371881 tatacacatg gcgcaggctg tacattctca gcagccgtga cagcggagct tgccaaaggt 3371941 gcggaagtca aagaagccat ttacgcagcg aaagaattca tcacagcggc cattaaagaa 3372001 tccttcccgc taaaccagta tgttggtcct acgaagcatt ctgcactgcg cctgaatcaa 3372061 caatcataaa aaaaggggct gccttacaga gaggcagccc tttttaaatc accgaagact 3372121 tttcacagaa aaaactgccg atcccatcgg cagcctgttt atttgatttt taaattgttt 3372181 gcagatttcc tcaaaaatgt ttctatcgac tgaacaaaaa gtgcatattc cttcatttgt 3372241 tcatatgccc gcgtgagaat ttccgccgtt tcactgtgcg gcgttgttcc gccaagcatt 3372301 tttttcagct gaagcagcac atccttatat tcttctcgct tatcttcaac ttggttagca 3372361 gccttttcca aacattccgg tgttatcttc tgttcatgta tattcaagaa aacaactcct 3372421 tttacagaaa aaaatagtag gttatcgttg aagaatagca cagatggctc agatttcaca 3372481 taagaaaata gaaggatttt ctacataagt gtccaaattc cgacattcat ttcagatttc 3372541 ccggtcgcac tggctgttac ttcatgattt cccgggaaag gaaaatatct tgcactcaag 3372601 acctcttctc cgttattgat aaagatttcc acagatgacg cgtcgagaaa catgtgtacg 3372661 gtatgcaaat ccttgatgcg gcaatgtctc gcttctgttc tttttccgtc aaagctcttt 3372721 cgttccagcg taacaatccc ctcgtcttta tggaaggaaa acgtagccgt tccgcggata 3372781 ctgattgaaa agccagactc cgtatgaatg tcttccagta gaatctcagt tctttcaggt 3372841 ttttccactg gaagcgcacc agatgatcca tgcatgttga tgtgtatttt tttctcattt 3372901 ctgcgcatgg cttttagctc aggcagcggc tgctgaatca gcttctgtcc tgaaagcgtc 3372961 agctgtctcg gcagcgtcat gcagtgaatc cagtggcagt caatggtcgg atgggaccct 3373021 tcatcctgat caggcaccgc catccatgca aataaaatcc gccttccctg atcgtcttca 3373081 agtgtttgcg gcgcgtaaaa atcaaaacct tgatcaagct ccgtaaattc accatgcttc 3373141 agttcaggct tgttataatc gaggcggccg acaaaataac ctgattgata tacgttctga 3373201 taacggaaac cgtcagcctc aagcccttga ggcgaaacaa tcagcacatc cgatccttga 3373261 agggaaaaca aatcagggca ttcccacatg tatccaaaat cgtccagccc gttgaagccc 3373321 gcgccggtta tcgggccaag aaatctccac tctgtcaggt tatcagaagc aaacaacaca 3373381 gcctgccctt tcaaattctc tgtttgcgca ccaatcacca tataccatgt gccttcatgc 3373441 tcccatacct tcggatcgcg aaaatgcgcc gtatatcctt ccggaaggcg ggcgacgaca 3373501 ccctttttct caaaggacag cccgtcgtca gaaacagcaa ggcattgata cgtttcccga 3373561 tttccatcct gatccctgac atttcctgtg taaaaaagat agagccgatc gtctttcgtg 3373621 acagcgctgc ccgagtagca gccgttttta tcaaaccaat cactcggagc cagcgcaatc 3373681 tcttcccgct tccaattcac aacatcctgt gtcgtataat gcccccaaaa ttttgcgccg 3373741 tgccccgtct gaaacggctg ccactgaaag aatacatgat agctgccctt ccaataaatc 3373801 acgccattcg ggtcattcag cagcccaacc ggcggcatga tatgaaaatg ctggcggtgc 3373861 ggatcgctgt tagcgatggg ctcttttttc tccacttctt cataagcccg gcgacgaagc 3373921 tcctggtcat gtgctgtcat tttttcctct cctcatcctc attaatcttc atgacaaatg 3373981 ctgcaatgaa cgctgacact gccgcaatcg ccatgccaat cagatagtga atcaagttgc 3374041 tgaagccaaa cggagccgca atggcgatca tcggaattcc cgttaacccg taagcgtttg 3374101 cagctacatg tgtaaagacg acatatgccc cacccaatgc gcctccgatc atcgcggcga 3374161 taaacggttt tcggtagcgc agattgactc cgaatatgac gggctcagta atgccgagaa 3374221 aagcggaaaa tgctgccgga agcgcgattt cttttgtctt tgcctttttc gccataaaga 3374281 agacggcaag acctgccccg ccctgtgcga cattcgccat tgaccagatc ggcagcaagt 3374341 agtttttgcc tatatctgca attagccctg cctcaatcgc atggaagctg tgatgaacgc 3374401 ctgtcagcac gatgagtgaa tacgtgcccc cgaaaatcag acctgcgaca aaaccggcat 3374461 ggtcatatac ataagttaaa gcaaccgtaa tgccggagcc aagcgctctg cctagagggc 3374521 caatcgcgat aaaagcaaca aacccggtga caatcacagt aacaaatggt gtaacaagca 3374581 aatccaccgc atgtggaacc acttttctcg tccatttctc taccttgctc atcacataca 3374641 ccgcaagcag gacagggata acagttccct ggtagccgag aagagcgata tcaaatccga 3374701 aaagatgcat gtaatcaggt gtcgcttccg ccaatcccca tggatttaaa agattcggat 3374761 gaatcatgat tcccccgatg accgctccca agtatggatt gctgccaaac tcttttgaag 3374821 cgctgacccc gattagaatc ggcaagaaaa tgaatgctgc acttgaaaac atatcaagca 3374881 gctgcaaaag cgcagaatcc ttgctcatcc aatgaaacgc attgatcata cccagcaatc 3374941 ccattaatag gccgctggct acaatagctg ggatgattgg aacaaaaata ttagaaagcg 3375001 ttttcgcaaa tctcgcagcg ggattcagct tttcttttgc cgcatcctga tgattgacgt 3375061 gttcttcacg ctcgatatca gcttctttag aaaaggcatc gaatacttta ttcacaaggc 3375121 ctgttccgaa aatgatctgg tactggccag agctgctgaa agccccttta acgccatcaa 3375181 gctcttctac ttgtgcttga tctatctttg attcatcttt catcactaaa cgcagtcttg 3375241 ttgcacaatg agccgcgctg ataatatttt ctttccctcc gagaagctca atgaggcgtt 3375301 ttgcagtctc tttgtaatcc atctatttct ccccctttta tttaaacaaa aaagacctaa 3375361 aattcgccaa cgaataaagg acacagcgat cctttttcat ttacgcaaat tttaggtctt 3375421 gcctgcttta ccagtcacaa tcccgcttat tcagattaag aatacgcttt catcataaat 3375481 catgatagcg ttttcgtcaa ctattttttt agttaaatag tttgatataa catgtagaca 3375541 aaaattcgta aaaattaatt gtgaaatact tcacaatatc gtgctatact atgctcaatc 3375601 atgaaagaaa gcaggaaaag acaatggaaa ctcaagcatt acaaaaggtt gaacagtatg 3375661 ctttgaaaaa acaaaacata ttcgcttcaa gcaaaatccg ttatgtgctt cggtccattt 3375721 tggccagtat atttattggt tttggcatta cagccgcaag caaaacaggc agctatttct 3375781 ttatggctga ttctccgttt gcctttccgg cagccgctgt cactttcggg gccgctattc 3375841 tgatgattgc ttacggaggc ggagatttat ttaccggcaa caccttttat ttcacctata 3375901 ccgcgctccg gaaaaaaatc agctggcgcg acaccctata cttgtggatg tcaagctatg 3375961 ccggcaattt aatcggcgcc attctgtttg ccatcctgat cagcgcgacg ggactttttg 3376021 aggagccttc tgttcattcc tttttgattc atttggcaga gcacaaaatg gagccgccgg 3376081 cttccgaatt gtttttcaga ggaatgctgt gcaattggct tgtgtgcctc gcctttttca 3376141 ttccaatgtc tctcaaaggg gaaggagcaa agctttttac catgatgctt ttcgttttct 3376201 gcttctttat ttccggcttt gaacacagca ttgccaatat gtgcacattc gccatctcgc 3376261 ttttgatcga gcaccctgat acagtgacac tgatgggagc agtcagaaac ttaatccccg 3376321 ttacgctcgg caatctgacc gcgggaatag ttatgatggg ctggatgtac tacacactga 3376381 atcctgatca ataaaaaaac ttccagagat cactccctgc aagtcaaagc ggttattccg 3376441 agagatcttg aagacgctgg acatgcagcg tgatatagcc ggcctcggat tccggcaaat 3376501 gtaattgata ttcatttttc aaaaactccg ccagctccag cgcacattga taggcgaatg 3376561 aatacttttt ttggatgaaa taaagcatct cctcgtccat acgatggagc gcttcatttg 3376621 attccaaccg gctgaccgcg tatcgcaaat gcgtgacaag gcgttgatag gaaatgctgt 3376681 tttcatccac ctttcgatta aagtattgtt ttattttctc tatcatttct ttgatcatgg 3376741 tcgtatgctt cagcgctgaa tacatgctct ccgcatccat cttcgccgta tggatgtgaa 3376801 gggcaatata acccgcttca tcttcaggca gagacacgcc caatgtctct tttacatgtc 3376861 cgatcgccca caggccgatc tcatattctt ttttatagag cgcctttatc tcatgcagca 3376921 atttattctg cacaagcagc ccattttgaa tcctttcgat cgcaaaggac aaatggtcgg 3376981 aaagcgcgat atgaatgtga tcgctcagcg gcgccgcgag ctctccttcc gcatagctga 3377041 tgatatcctc agctatttct atatgctcct ccggcagtgt ttgcaggatt tgtttgaact 3377101 tttcattctc gtcgcgcacg acaaagatct tttccacttt attcataggg atgagatcat 3377161 ttttcttttt ttgaaaagcg attcccggtc ccatcacgat tttttcctga tcatcctctt 3377221 ttattaaagc cgcattgttg tttaatactt tatagatttt caagaggtta tctctcccgc 3377281 caatttgctt ttgactggga ttttacctcc ttttgaccgc catgtaaaga tgcgggcccg 3377341 ctctctcctg ctttggcgat tccttgaagg cttgcaaaca tcttctttta taaagcgcgg 3377401 cggctttcgc tttctgcttt tcttcctcat tcacagccat ccgccattca taaaacgaaa 3377461 cgagtcctgc ggcctgcaca gccgcctttc tttggtatgt acgctgagcc gaatagaccg 3377521 cggcagccgc agtttttctg tccggcgtca cccagttcat caaaaagacc atccacaccc 3377581 gtaaagatac aagcaaacgt ttcatagaaa aacatccctc cgcttctttt tggcaggcag 3377641 cctttttagc agcccgtttt ctcagccgca gcccgcaaga aaagacggcc gatttctttt 3377701 ctcgcaaact agcggctcta gcaaaactca tgactctatg atagaccgtg gaaagagaat 3377761 tctttgtcac aatatgagtg aaaaaaccaa ctagttttta gaagttttgt tgaaagctga 3377821 aagaattgaa atgaaaattg gagaaccgct ttgaaaactt tatacacaag ttatcccaaa 3377881 gataagaaca acttaatcac aagagatatc cacatgtcca caaactctat ctatattttg 3377941 tatacgaacg tatattccta actatatata tacacaggtt tattcactta tacacagggt 3378001 tctgtgtata actccttcgt tatacacaaa caaaatccaa taaatggtcc aaatgacaca 3378061 aggatttttt tgaattttca agaaatatat actagatctt tcacattttt tctaaataca 3378121 aagggggaaa cacattgaaa aaggggatca ttcgctttct gcttgtaagt ttcgtcttat 3378181 tttttgcgtt atccacaggc attacgggcg ttcaggcagc tccggcttct tcaaaaacgt 3378241 cggctgatct ggaaaaagcc gaggtattcg gtgatatcga tatgacgaca agcaaaaaaa 3378301 caaccgttat agtggaatta aaagaaaaat ccttggcaga agcgaaggaa gcgggagaaa 3378361 gccaatcgaa aagcaagctg aaaaccgctc gcaccaaagc aaaaaacaaa gcaatcaaag 3378421 cagtgaaaaa cggaaaagta aaccgggaat atgagcaggt attctcaggc ttctctatga 3378481 agcttccagc taatgagatt ccaaaacttc tagcggtaaa agacgttaag gcagtgtacc 3378541 cgaacgtcac atataaaaca gacaatatga aggataaaga cgtcacaatc tccgaagacg 3378601 ccgtatctcc gcaaatggat gacagtgcgc cttatatcgg agcaaacgat gcatgggatt 3378661 taggctacac aggaaaaggc atcaaggtgg cgattattga cactggggtt gaatacaatc 3378721 acccagatct gaagaaaaac tttggacaat ataaaggata cgattttgtg gacaatgatt 3378781 acgatccaaa agaaacacca accggcgatc cgaggggcga ggcaactgac catggcacac 3378841 acgtagccgg aactgtggct gcaaacggaa cgattaaagg cgtagcgcct gatgccacac 3378901 ttcttgctta tcgtgtgtta gggcctggcg gaagcggcac aacggaaaac gtcatcgcgg 3378961 gcgtggaacg tgcagtgcag gacggggcag atgtgatgaa cctgtctctc ggaaactctt 3379021 taaacaaccc ggactgggcg acaagcacag cgcttgactg ggccatgtca gaaggcgttg 3379081 tcgctgttac ctcaaacggc aacagcggac cgaacggctg gacagtcgga tcgccgggca 3379141 catcaagaga agcgatttct gtcggtgcga ctcagctgcc gctcaatgaa tacgccgtca 3379201 ctttcggctc ctactcttca gcaaaagtga tgggctacaa caaagaggac gacgtcaaag 3379261 cgctcaataa caaagaagtt gagcttgtcg aagcgggaat cggcgaagca aaggattttg 3379321 aagggaaaga cctgacaggc aaagtcgccg ttgtcaaacg aggcagcatt gcatttgtgg 3379381 ataaagcgga taacgctaaa aaagccggtg caatcggcat ggttgtgtat aacaacctct 3379441 ctggagaaat tgaagccaat gtgccaggca tgtctgtccc aacgattaag ctttcattag 3379501 aagacggcga aaaactcgtc agcgccctga aagctggtga gacaaaaaca acattcaagt 3379561 tgacggtctc aaaagcgctc ggtgaacaag tcgctgattt ctcatcacgc ggccctgtta 3379621 tggatacgtg gatgattaag cctgatattt ccgcgccagg ggtcaatatc gtgagcacga 3379681 tcccaacaca cgatcctgac catccatacg gctacggatc aaaacaagga acaagcatgg 3379741 catcgcctca tattgccgga gcggttgccg ttattaaaca agccaaacca aagtggagcg 3379801 ttgaacagat taaagccgcc atcatgaata ccgctgtcac tttaaaggat agcgatgggg 3379861 aagtatatcc gcataacgct caaggcgcag gcagcgcaag aattatgaac gcaatcaaag 3379921 ccgattcgct cgtctcacct ggaagctatt catacggcac gttcttgaag gaaaacggaa 3379981 acgaaacaaa aaatgaaacg tttacgattg aaaatcaatc ttccattaga aagtcataca 3380041 cacttgaata ctcatttaat ggcagcggca tttccacatc cggcacaagc cgtgttgtga 3380101 ttccggcaca tcaaaccggg aaagccactg caaaagtaaa ggtcaatacg aagaaaacaa 3380161 aagctggcac ctatgaagga acggttatcg tcagagaagg cggaaaaacg gtcgctaagg 3380221 tacctacatt gctgattgtg aaagagcccg attatccgag agtcacatct gtctctgtca 3380281 gcgaagggtc tgtacaaggt acctatcaaa ttgaaaccta ccttcctgcg ggagcggaag 3380341 agctggcgtt cctcgtctat gacagcaacc ttgatttcgc aggccaagcc ggcatttata 3380401 aaaaccaaga taaaggttac cagtactttg actgggacgg cacgattaat ggcggaacca 3380461 aacttccggc cggagagtat tacttgctcg catatgccgc gaacaaaggc aagtcaagcc 3380521 aggttttgac cgaagaacct ttcactgttg aataagaaaa agccctgccg attcggcagg 3380581 gctttttaaa gatcagtcag caaacgcctc ctgcaataag cgatacgatc ggagcttatc 3380641 ttcaaaatga tgcgtgatgg tcaccaccat gatttcctct gtttcatacg cgttactcaa 3380701 agctaacagc cgctccttaa cctgttcttt cgtaccaaca atcattcgat ttcgattatc 3380761 agcaattcgt ctctgttcat aaggagaata cgtatttttc cgaacagctt catacgaagg 3380821 aactccctct aaaggaatac cctgctctcc cgccaaaagt gtaaaatcaa gcacagcccc 3380881 aagctcctct gccttctcct ccgtgtcagc acaaagaaca aaaacagcaa ctgccgctcg 3380941 aggcgtatct cctaacacag acggtttgaa tcgcctctta tactgtctga cagtaccctc 3381001 tccgccctct ccattgataa aatgggcaaa catatagcca gcgccagatt cagctgcgag 3381061 cagcgcgctt tctccagatg agccgagcag ccacacatcc ggagccgttg aaatatgcgg 3381121 cgcagcggtc agattcggaa aacggtgttt gtcatccgcc aaatcatgca aatacatggt 3381181 cagctcctta atttgctgcg gatactgatc agcattgcgc ttaccaccgt cattcagcgc 3381241 ccatgatgca atcggcattc cccccggtgc tctgccaagc cccaggtcaa ttcttcctgg 3381301 tgtcagcccc tccagaacac gaaagttttc agctacttta taagcactgt aatgcggcag 3381361 catgactcct cctgatccaa cacgaattcg ctttgttttc gctgctatat gactgattag 3381421 cacctcagga ctggaccctg ccagccgttt tgaaaagtga tgctcagaaa cccaaaatct 3381481 cttatatcca aggtcctcag cagcttgggc aagcgcaacg gtttgctgta aggccgtttc 3381541 tgcattgctg ccctctgata ctggagattg atctaatata cttaatgaaa ccatccctac 3381601 cacctcatcc tcatcgtatc actgatcccc tattttttct ccaaagccgc tcacactgct 3381661 tatcagtgtc ccctatcatt cgccatttat ttgtgaaagc atgtccctat ttgtcggaat 3381721 atgttacacg tgaaacataa aaacccctcc agacggagag gtttgcttta gtttttatta 3381781 aagccctttt ctttcacgta gtcatttaaa tacgtacgcg gcttttgctt cataaagttc 3381841 agtatttgat cggaccacgt ttcttcccgc ttcccgtttg ttctttctct atagtaatca 3381901 gaaatggttt tgtcatacgt attcatagta tgacggaaat cgtctgtgtt cacattatac 3381961 gtattttcat gataaacggc ctgctttggc aatctcggtt ttttgccgga aaggttcgca 3382021 ggatggccta ctgccagtcc gaaaagcggg agcacatggt caggcgtttg cagcacctct 3382081 gtcaccttgt ccaattcatt ccgaatgccg ccgatatagc aaatgccaag ccccatggat 3382141 tcagcggcaa tgctcatatt ttgcgctgcc agcgccgcat caatcaagct aaccataaac 3382201 atttctgtat tctcgagcag ctcagaaata tgttcacctt tttcctcagc cagttgttga 3382261 tggcggtaca aatccgcaca aaatacaaaa aagtgtccgt tcttctcaac gtaaggctga 3382321 ttcccagcaa gcacggacag ctcacgtttt ttctcaggat cagaaacccc gataatcgaa 3382381 tatgcctgca catagctgga tgtagacgca gcctgcgcac ttttcactaa tgtatcaatt 3382441 tcttcagctg tcaaaagctg atcagtaaaa gaccggattg accgatgatt caaaatggtt 3382501 tcgattgtgt tattcatcac aaaaacctcc ttatcacttt ttatcatatc cgaaaaaaag 3382561 tgatctcaaa agtgaaatgc tctgcacaaa aaaagacagc ctctgtaaag gctgtctgca 3382621 tatcaagaat taaaaagata acttctgtat ttcgtcagct gcacacttgc attatataca 3382681 atcccaaatc cgattaacgt ggaaagtgtc gagcttcccc catagctgac aaacagcagc 3382741 ggaatcccgg taacaggcat aatgccaatg ttcattccga tattctggaa tgtgtggatc 3382801 acaattaacg ccgtatagcc aacgcaaaag aaagaagcga aacggttaaa cggatgtatt 3382861 ttgtctatca gaacaacaag cctgtagatt aaaaagaaga acatgatgac aacaattgca 3382921 cagcctataa agccaaatga ctcacctatt atagaaaaga taaagtcagt cgtactctct 3382981 ggaacataaa ccttcaaatt agaaatacca ttacctaaaa taccaccaga tcctattgcc 3383041 atgatggcct ggtcaacttg ccagctgtca tttgaatctt cctgtgtctc atttgaagca 3383101 gacacccaag aagtgacccg cttaatttga taatcctgta ttccaactga tttagcaacg 3383161 tcaggaaagt ttatcattac taataaaatt aatgaaatga gtaagatacc tgaaccagct 3383221 atgatcgcaa tcaatttcca atttatccct gacataaaaa ccattacaag aacgataaac 3383281 atacatattc ccgcagtccc agcatcctgc atcaggataa gacctacagg aataactgcg 3383341 acacccgcaa tctttaataa caagtggata tcatccctaa gcgtccgaac tcctttagga 3383401 tttgcttttc caataactga agcaagcatc ataatcaaac caaccttcat aaactctgac 3383461 ggctgtattg ttattctacc gatcctaaac caactttttg cccctttaat aacaggtgca 3383521 atagactcgg gactgatttt aagaataatc aaagataaaa taccaatgat aaaaatatat 3383581 aaacttaact tttcaagctg ttctaaatca aagtacaaaa gaactgtaat ggctacagcc 3383641 cccaaaagat aaaacacaat ttgctgaatc caatccgtgt tcccatactg cccaaactga 3383701 ccggcagcat atattgatac tacgcttata ataaaaaaca caccaaatat aaaaatcaaa 3383761 tccccctggt aaaaggggct ttgctgtttc ttatatcgac tcattctatc ccgccttaca 3383821 ttttcatcgg aaaatcacta atgtttatta tacatgaacc acgttcaaga tgacacgtga 3383881 agctcgcttc cttttatgtt ttttcagcat ttgcggcgct ttttcagcta cacgaaatat 3383941 gacgtatcat aaaccgaaat gtttcgattg acacaaaact tttcaaatga aaaaaacgcc 3384001 ataccaatag aatttgttaa aaaacgaatg cgataatgtg ttatgttccc aaataatgtg 3384061 atacctcata tagaaatagc taaaaattca gagccccatg cccatacatt ctcctagcac 3384121 attaaacgaa aaaataagac gatagatcca gtccatttct gcaaaaacac gtatcaattt 3384181 ctggaaaaca tggtataata attgtaacag aatgttcaaa aaacaatcac aaaacagaca 3384241 caactcagtt cctctatttc atttttgtaa acgttatcac aaaatgaaag gagacgggta 3384301 tgatggacat gttttttgct tacttattgg ttgccagcgc aacgcctctc tttatttggc 3384361 ttgataacaa aaaagtcgca ctctcagcta ttccgccaat cattttaatg tgggtattct 3384421 tcttctttta cgcaacagaa agcctttctc cacttggaca cactctcatg attatcttgt 3384481 ttgccgttaa cgtcattgtc gctcatatcg ccgcatttat catttacggc cttccgtatc 3384541 ttcgcagaaa gcgaagcagc tgaagacagc aaaaaaccct cttccactga agagggtttt 3384601 ttgtattatt cgttatggcc tgaatgctct gagtgttcag cgcctccagg aggatttccg 3384661 tccatatggt caccatggtg atagtgagcc gcgaaaatcc agatggatcc aagtacgata 3384721 acgatcgcgc caaagaatcc gaacagcgtg tttccgactt ggatcgtgcc gttttcgctc 3384781 tctgtcatat gcatgaacat gagaagctgc agcgccgcct gaatgaaggc gaagccgaag 3384841 ataatccaaa gttttgctga tgagctcagg tcagtataca ctgcaaccca tagagccagc 3384901 agggtcaaaa cgatagacag gataaaacct acaatgtgtt tccatggaaa gtgactgtgt 3384961 tcagcagatt tgtttgccat tttacagacc ccccaatccc atgagataga cacctgtaaa 3385021 gatgaaaatc catacaacat ctaagaagtg ccagtacaag cttgagataa agattttaga 3385081 tgaagtttgc ggagttaagc cgcgtttctt caactgaatc agaattcctg tgatccagaa 3385141 aatcccgatt gttacgtgag ttccgtgagt tccaagtaaa acaaagaatc cagaccagaa 3385201 cgcacttgta ctgagagccg ctccttcatg tacatagtga acaaactcgt tgatctcgca 3385261 tccgacgaag ccggcaccga gaagaagagt gataattgtc caaatgacta cgccttttaa 3385321 acttccgcgg cgcatttcat gaacagcgat cccgcaggta aagctgctga tcagcagcaa 3385381 gaacgtcata atcattacca gattgacttc aaatagttcg tctggcaaga cacctccagc 3385441 tgttctgttt ttaagaacga agaaggttgc aaatagtgtt gagaacaaca caatttctgc 3385501 ccctaaaaag atccaaaacc cgagaatatt aagtctgccg gtttcagatt gatattccat 3385561 aggcgcgtta gaattgccgt gttctgcatg ttccataact cacgcctcct tattcggaaa 3385621 tctttctttc cgtctctttt atttcatcaa cactaatgta gtagccgttg tcgtattcga 3385681 atgaacgcag aaccatgcag agcaggactc cgatcaatcc gactacgccc atccagtacc 3385741 attcaaagac aagtccaaag cctgcgagac cgaaggcaac agacataaag aacggtctgc 3385801 ctgagttgct tggcatatgg attttcttga atttgctttc agggtataat tcagtttttt 3385861 cttctttcat atgcaggaat gcatcttgag atttgacttc aggaagcacc gcaaagttgt 3385921 aatgcggcgg aatcgcagaa gaagtcgccc aatcaagcgt acgtcccaca ccccatgaat 3385981 ctccgctgat ttcacgagta gagtaacgga agctgtagta gatgttatag caaaggatta 3386041 agaatcctac acccatcatg aaagctccga ctgttgagat aaagttcaat gttgtccagc 3386101 cgtcattcgg tccgtatgtg taaatacggc gcggcatgcc ttgaagcccc aagaaatatt 3386161 gcgggaagaa acaaatattg aacccgatca taaagatcca gaagaaccat tttccgattc 3386221 tttcgttcag cttgtggccg aacatttttg gataccagaa aataaatccg gcgaaacaag 3386281 caaatacagt acccgcaatc agcacatagt ggaagtgaga tacaaggaag tacgtattat 3386341 ggtattgata atccgctgct gccatcgcaa gcataacccc tgtaaccccg ccgataacga 3386401 agttaggaat gaacgcaagc gcccacagca taggtgttgt aaagctgatt cggcctttat 3386461 acattgtaaa gagccagtta aagattttaa ccccggttgg gattgagatt gccattgtcg 3386521 taattgagaa gaatgagtta acggacgcac tgttccccat tgtgaagaag tggtgagtcc 3386581 aaactaagaa actcaataca gagatggcga taatagaacc aaccatcgct ttgtaaccaa 3386641 acaattgttt tcttgcaaag cttgagatga tttctgagaa aataccaaac gccggaagaa 3386701 taacgatata tacttcagga tgtccccaaa tccagaacaa gttagcccaa agcatcggca 3386761 taccgcctgc ttccaatgtg aaaaagtgag cgccgaacaa acgatcaaat gataaaagtg 3386821 ctaatgctac tgtaagtaca gggaacgcaa acacgataat aaccattgtg atcagtgttg 3386881 tccatgtgaa catcggcata cgcattaatg tcatgccttt tgttctcatt tttaagattg 3386941 ttaccataaa gttgatccct gtcatcaggg taccgatacc ggcaatctga agtccgagga 3387001 ggtagtagtt ctcacccggc ccagggctca tgtcgttact tgcaagcggc atataactcg 3387061 tccagcctgc gttcggagaa cctccgataa cgaaagaaat attgaaaagc atcgccccta 3387121 caaagaacgt ccagaagctc aggttgttca agtaagggaa cgcaacgtcg cgggcaccga 3387181 tttgaagagg cacaacaacg ttgataagac cgattaagaa cggcatcgcc atgaagatga 3387241 tcatgattgt accgtgagtt gtaaaaattt cattatagtg gtttgagtct aaaaaactgt 3387301 tattcggaag cgctagctgg gcacgcatca tcagaccgtc gacaccgcca cggaataaca 3387361 taattacagc agatataata tacatgattc cgagtttttt atggtcaaca gtagttatcc 3387421 attcagacca cagccatttc cactttttga agtaagtcag aacaaaaata atggcaatgg 3387481 ttgaaagcgc aatggaaact tgtgcgccca gaattaatgg gtcaccagtt acgaaaaatt 3387541 cgtcccattt gaatttcatg caggcttcct cctttcctga tcaatatcat tcttctgtat 3387601 catcagactt cttaaattcg tttttcttta cgttttcaaa cggatctgtt ttagaatgcg 3387661 gtgaaacggc ttgatagcca aggcgtttgc gcgcctccat cgcgtactca gcgtcttgtc 3387721 cgtgatcaac gtatttcaag tgagtagaag agaacgttaa ttcgtccaca ttttcaggaa 3387781 gcatcaattc atcatacttc tcttttgtca gcttaggagc ctcgttctga gtctttttca 3387841 cccagctgtt aaagtctttt tctgtgactg cattcacatc aaactcttgg tctgcaaaat 3387901 gttcacctgt gaagttcgcg ttgcggcctt cgtaagtacc cactttgtca gcctgtaagt 3387961 attgatccat cagcattcct gccatcgcat atttttgccc tccaagctga ggaatccata 3388021 gcgaagccat tgaatctgca gatgagattt tgaacaagat cgggcggtcg acaggaatgt 3388081 ttaagtagtt gaccgtttca atatcctgtt cagggtagct aaatacccat ttccagtcta 3388141 ccgaagtagc ataaacaaca agaggctctt tgtcttttgt tgcttcagga gctttttcta 3388201 acgaatatat cgtctgtact gttggcacag aaagtgcaat gacgattaaa attgggatca 3388261 ctgtccagac tacttctaaa aacgtgttac cgtgaatttc tgggttataa gatccattat 3388321 ctttgccttt acggtcgcgg tattttacta aaataatggt aaatagaaca aagacgaccc 3388381 cgacgataaa cagcataaat ccgatagata acaggattaa atcactttgc tgttcagcta 3388441 caggtccttt cggatctagt actgaagcat tgctgcatcc cccaaggacg aaaaccacag 3388501 ttaacagcgc taatacaagc aacggtttta atgctctgaa caagaagatc accatccttc 3388561 ctattgatgt aataaatctg aagtgcatac ttcctcaaaa tcttttctct actttgttat 3388621 gctatcaaaa acttcactta ttagctttat ttttttataa acttcatccc attttcgctt 3388681 aaatgtcata aaatcgacaa aaattgctcc aactttattc acatctatcg cttaagatga 3388741 aaagtttcta gttatttccg catataaagt aaagaaagat gatgaagaac taattctgac 3388801 aaattaaggt ttaccacaat aaaaaactta ggtcaatcaa aaatttcatt ttgttaaact 3388861 ttctagatag gaattatttt ttcctcgtct agcatctttt cacacggtta ccattttaac 3388921 gcatcaaata ttgaaagaaa aggcgcaatg aagagccaat atgctctgaa ttgtccgtat 3388981 ttttttatga gagcatccag ttgtttatct tatacaaaaa agaggaatga tataagcaaa 3389041 taaataaaaa ataggatgtg ttgcatgatg agttttctta tttcacttat cgtcgctatt 3389101 attatcggat ggcttggaag cctgtttgta aaaggagata tgcccggagg aattatcggg 3389161 tctatgatcg caggtcttat aggcgcctgg atcggacacg ggctgcttgg aacatggggg 3389221 ccgcacctag ccggatttgc cattattcca gcggtaatcg gcgcagccat tgttgtcttt 3389281 ctagtaagcc tgttaaccag aaaaagagga taaaagcagc agcacccgaa gcgtcagcgc 3389341 tttgggtgtt tgttttgcca taaaaatcga aaaagcctca accctagcgg ttgaggcttt 3389401 tgactggttt ggcgcccaac tgatcgatga accttctgaa ggcctgtttt ccctctgctg 3389461 tctgcttaaa tacaccggcg tgttcaagga tgcgcgcgaa tacatgtccc agctcttctt 3389521 ttatgactag atctacgttc tcttttgtta tggttctttt ttccatcgtc cgaagagccc 3389581 actcactatg ctttgcagtg agcggatttt gttctaaggc tgttttcgga tcagcagaac 3389641 atagcgccgc tgccgtttct ttcatttcct cctgtaagcg gccaggcaat atcgccaatc 3389701 ccatgacctc aatcaggccg atattttctt ttttaatatg gtggacttct tgatgaggat 3389761 gaaatattcc taatggatgc tcctcatccg tccggttgtt cctcagtacg atatcgagtt 3389821 cgtacaagtc tcccctgcgc cgcgcaatcg gtgtgaccgt attatggggc gtatcgcctg 3389881 tataggcggc aatgccggct ttttcatcgg aatacgtctg ccacgtgcgg aagatatggt 3389941 cagcagcttc ggcgacatga cccggttcgt ctccttggag cctgagcaca gacatcggcc 3390001 acttcactaa gcccagcgac acgccgggat aatcatttaa ttcataaacg tcttccgctt 3390061 ctgcacgtgc cattggaaaa tcatgcgcgc cgccttggaa atgatcatgg cttaggatgc 3390121 tgccgccgac aatcggcaga tccgcgtttg aaccgataaa ataatgcgga tattggccaa 3390181 gaaatgacag cagcctttca aatgtttttt tgctgatctc catcggttca tgttcacctt 3390241 ttaagacaat gcagtgctcc ggataataga catatggcga gaattgcagg aaccattgtt 3390301 cgtcctcaag gatgaccgga atgattctgt gattttgccg ggctggatga ttcacgcttc 3390361 cctcgaagcc gacattttct ttacacagca aacacatcgg ataatttgtc tgttcctgct 3390421 cttttgcagc cgcaatcgct ttcgggtcct tttcaggctt tgataggtta atggtcattt 3390481 ccagctcgcc atattcggtc ggcaccgtcc aatgaacatt tttggcgatt ctgtcagtcc 3390541 gtatataata gacatcctct gaatattgat agaattcctt tgtcgcctgt tttgggccgt 3390601 ataatgcttt tgtctcttca aatttgcgaa tgacctcgga cggggcaggc acaaaacagc 3390661 ccatcagctt tgcgctgagc aggtcacggt acgtatctgt atccgcttcc attcggccgg 3390721 tttcggcagc ccatttatag atgggagcta gcaagtccgg caggctttgt gactgcttga 3390781 tgctggtgct ggagttcggc tcgggatgtg tgatgcccag cgcttcataa agacggtttc 3390841 tcgtatattc ccgatcccag atcgaaatca attttcgttc caggccatac tcaagcagct 3390901 gttccagatg ttcaataata ctcatatgtc actccccctt tagttctctc gctccctctc 3390961 cgatatccgc gacataaaag tccgctcgga gccctgtttt ttcttgatat ctgtctccaa 3391021 ccttctgaat aaaatcatca acgaactcat cttttacaat gctgatggtg cagccgccaa 3391081 agcctgctcc cgtcattctt gatccaatta caccttcgtg atcccatgcc gcaaacacaa 3391141 gctcatcaag ttcagggcat gttacttcat agtcatcctt caatgaaagg tgggattcct 3391201 tcattaactg cccgatttca tctatattgt tctctttgaa catatgggcc gtcttaatag 3391261 cacgatgatt ttcgtataca gcgtgctttg cccggcgtct gttcgtttca ttttggatca 3391321 ggctggaatg cgcatcgaaa tcagaaggct tgatgtcgcc cagtgcggca atatcgaggc 3391381 cttttttcag atcaagcaat gcatcattgc attcttggcg tctcgtatta tagctggagt 3391441 cagccaatgt cctttttttg ttcgtgttcg cgatgaccag cgcgaggcct gagacattga 3391501 gtttgctata ttcatagtca agcgtgtcac agttcagcag catcgcatga tgttttttcc 3391561 ccattccaat tgcaaattgg tccataattc cgcaattgac gccgataaaa tggttttccg 3391621 catgctgcgc cattttcaca agctcaagcg catctacttc aggatgaaaa taactttgga 3391681 gcacgacccc catcagcagt tcaatagaag cggaagacga cagtcccgcc ccgtttggaa 3391741 tattccctga aaatacaatg tcaaagccat ggggaactgc atatcccctc tgttgaaatt 3391801 cataaatcac gccttttggg tagttcgccc agtcgtcttc tttttgatag cgaatgtcgt 3391861 caaggctgca ttccttgatg cctgcgtttc taaagttatc tgaatacatc cggacaagcc 3391921 cgtcgtttct ttctgcaaca gcagcatatg tacccattgt cagcgcgcac ggaaagacat 3391981 gcccgccgtt atagtctgta tgttctccaa tcagattcac tcttccaggt gcgaaaaaaa 3392041 accgtaaccc ctctttttct ccgaatacac ttgcaaatat cccctttagc tcttcccgca 3392101 tgtgcaatca cctttctggt ttttattttt tattcccctt atttcttcat agaaaacggc 3392161 agatcatatg ctgcagtcct ctcatacccc ttcttctttt gtttttttaa agacgagcca 3392221 tttgctcgca acatagttga cgacaacaat gaccgcgttg tcgagtattt tggccaaggt 3392281 ttcatttgta ttgaactggc cgacaagaat gatcatcatg cctaaatcta tgccgagaga 3392341 caggacccga acgctgaaaa aagcagtgag ctctttcagc aggctctgca gatcatgtgt 3392401 tttttgctga aacacatata atttatttgt tatgtaagca aacagcacgg acaaaatcca 3392461 agcggcaaca gtggcggctt tgtaatccac attcatgatc tctaccaata tataaaagct 3392521 ggcgatattc acaatggttg tgaaaacccc cataatgata tacataatta tttctctata 3392581 cttcactgat gttcctcgct ttctgaaaaa cttttcaaaa ttcttggcct ctcgtgctct 3392641 ctgtctaaag taaaaaatac cgagagtgcg tctaaaaagc tgcggaaggt ggctggctgg 3392701 cccaatacat atgattgttt gatgattccg tcgaggactg cacatattat tttagccgta 3392761 tattcaggat caatacaggc gtcaatcagc tttctctcct tcagccactt aatatataac 3392821 acattttctt ccacccacaa ttcgtacagc cggacatagg ccttgcattt ctttaagact 3392881 ttatatgtcg gcatgttcat ggcaaacgag gtgatgtccc acgacggctt atttatgtaa 3392941 taggaataaa gcagttctgc agcgtgtttt gcagcctcgt ccaatgtcag cgatttcact 3393001 gactcccgct ccatttgatc aagataccct ataatgatct tttttttcat ctgacgtttt 3393061 tcgagaaggt acagcagaaa atcgtccttg ctgacaaaat gaacataaaa tgctcctttg 3393121 ctgtacccgg cggctctgct gatatcttct acagaaaccg gatcatacgc tcggtcaatc 3393181 aacaaattca cgccagcgtc tataaaactt tcaaatgttg cttctctttt aatttgaaat 3393241 ttgttttttt tcatattttt ctcctggcgg taatgattac ccttatctta caccggatca 3393301 atctttagcg gtatttattt ctttaaacgg ttatgctatt cggtttccca ggggtcattt 3393361 ttaataggct aaatgattta ttttcattta catactatcc agtcagtatt taattgttta 3393421 ttattataaa taaggtccat tggttatatt agtcattttt ttagggaata ggtaggtggt 3393481 ttttccttca gtttgtgaac accgagcaac tatgtgtgaa atttgttgta ctcgcctcca 3393541 tcatcgcgct ggcttgtctt ttattgcccg catgttgcag gaaaacattt tatacaattg 3393601 gaggttacta tgaaaactca tgttaaaaaa gatttggaca aaggttggca tatgttaatt 3393661 caagaagcta gatccattgg attaggcatt catgatgtga ggcagttttt agaatctgag 3393721 acagcatcaa gaaagaaaaa ccacaaaaaa accgtccggc aagactagtc cgaacaggcg 3393781 gatctattta cctctggctt ttctatcacc tgatctgagt tttcaccata tcctctattc 3393841 aaaagcaaat cgctgcgctg agcttgagga caaacggtgt gtcagctaac tacgacagac 3393901 agccggtgat gcgatcacct cttggcacat gcattgtcat aaagaggtga tgcgaacatg 3393961 ataaccgtgc tctggtaaac agcagctttg ctgagaacaa gctgcattcg gtgaggtttt 3394021 gaaagcaaac tcgtttatac acggccgagc ttgaaaacct tcgcctgtct ttagaccact 3394081 gtgttcacct cttcacgact tccttctttt ttcatcctcc agctattgta caacgcataa 3394141 atcggacttt cagtacatac ctattggtgt acctttttgc ttacgtttag cgaataaaag 3394201 gaggaaagcc atgtacaaag ctgattataa acagattgct gcaacgccgt cttttcaagc 3394261 ttttttaaag cagaaacgcg cttttattgt tccttctgcg attttctttt ttgtttttta 3394321 tttttcactc cctgttttga catcttattt cacctttttg aatgcaccgg ccattggagc 3394381 tgtttcatgg gcttggctgt tcgccatcgc ccaattcgct atgacctgga tactgagtac 3394441 tgtgtattcc cggagagccg cccatttcga taagtatgta agcgctttaa aagaggatct 3394501 gaagggtgaa cagacatgaa tatgactgct tttttattat ttttggcgat tgttggcctg 3394561 acgcttatta tcacgtattt tgccgcgaag cggacgaaaa cgacgagtga gttttatacg 3394621 gcgggcggcg ggctcaccgg cgttcagaat ggactggcaa ttgccggtga ctacatgtct 3394681 gccgcctcgt ttctcgggat tgccggaatg attgcgttat atggatttga tggcttcttt 3394741 tacagcatcg gttttctggt ggcttatctc gttgtcttgt acatcgtggc ggagccgctt 3394801 cggaatcttg gaaagtacac gatggcagac atgattgccg ctcgctttaa agaaaagaaa 3394861 atccgcggtg tcgcggctct caataccatt gccatctcta ctttttatat gatcgcccag 3394921 ctcgtggggg cgggcgcgct gatcaaactg cttctagggc tggattatac cgcggctgtc 3394981 ctcatcgtcg gagtgctgat gaccatttat gtcgtgtttg gcggcatgat cgcgacaagc 3395041 tgggttcaaa ttattaaagc tgttttgctg atggccggca cactcgtgat ttcgattatc 3395101 gtgttttcga aattcggctt tagccttaat accatgtttg aacagatgaa aacggctact 3395161 ccgcttggcg ctgatttttt gaaccccgga aataaataca aggtgccgct tgagaccttg 3395221 tcgttaaact tggcactcgt gctgggaacc gccgggcttc cgcatatatt gatccggttt 3395281 tataccgtta aggatgccaa gacggcccgt acatccgttg tgtcagcgac atggattatc 3395341 ggtgtgtttt acattatgac ggtatttctc ggctttggtg ccgcggcatt tgtcggtttt 3395401 gacgcgatta cggcggctga tcaagcggga aatatggcgg ctccgctttt agcaaaagcg 3395461 ctcggaggag actttctgtt cgcgtttgta tcagccatcg cctttgccac cattttggct 3395521 gtcgtgacag ggttggtgct gtctgccgcc tcagcatttg cccatgatat ttacagccag 3395581 atcatcagaa agggagaagc aactgaaaaa gaacaaatga aagcggccag atgggcttct 3395641 gtcgccgtgt cagtgctctc gattctcctt gcgatttttg cacaatcctt aaatgtggcg 3395701 ttccttgttg cactcgcgtt tgcggtagcc gccagcgcaa accttccgct gattgtgttt 3395761 acagtcttct ggaaacgatt caatgcctca ggcgctttat ggggcagcct gacaggcctg 3395821 atcagcgcgc ttgtgctggt atcgatgagc cctagtgtgt gggacccggc cggaggtgct 3395881 atttttaccg gtgatccgct cattccgcta tctaatccag gaattatttc catcccgctc 3395941 ggctttctcg gcgcgtggct cggaacggtg ctgtcgtctg ataaaacaat tgatgaagat 3396001 acgtttgcag aaattcaggt gaaggcgcat actggcgtcc atatggaaca ggaataaaaa 3396061 aagctctctt tatcgagagc tttttcctta ctttttcttc tgctcgtcag aaatcgcttt 3396121 ttcaaataca tccttgccgg cagcacccgg aattacagtg tcaccgataa taaaggttgg 3396181 aacggctgtg atgtcagcct cttcataggc gtgcttcaag gcttggcgct gcacgtcctg 3396241 atatgttctt gtttccagtg ctgatttgaa tgatgcaccg tctaatccca cttcctcggc 3396301 gagcttcgtc aagatgtcaa tatcgccgat attttggtcc tcctggaaaa atgcctgaaa 3396361 gacacgggtg ttgtattcat gtcctttatt gtattccttc gcaaaatgga agccttcaaa 3396421 cgcgaggtct gtatacggat ggggcgagac gtttggaaaa ttgatctcga ctcctaattt 3396481 ctccgccatt ggctgaattg atgtctgcca catgtactgt ttagaaggat cattgaccgg 3396541 atcaagctga ggagatgggc ttgggcgcag ttcaaacggc atccactcga cttcaacatc 3396601 ctttcctttt atcgcttctt caaaagcggc ttttccaaca aaacaaaatg ggcagacgta 3396661 atctgaataa actttaatgt gtactgtcat gataatctcc tttcatacta aattgatttt 3396721 aaactgtaac aattaaagtt acaactgttt tttaataaag aagccgattt aggcttcttt 3396781 cagattgatg acaaaatcct aaaaagtttt aggattttgt catcctttca gcgtgattga 3396841 aaacccttga agtctaggaa agccgagcat tggagcggag cgaatgctct aattcgtgag 3396901 caccaacgca caggcttgac aacgaatgcg agggtttgtc gacacgctga aagaagcctg 3396961 taaaggcttc ttttatgatt ccagcaaacg ctgggcaata tattctcctt ttttgcagcc 3397021 gcctgggcat gcgtataaag cagaaccgat tgtttgtgta tattcgttta acgcatcctt 3397081 tgctgaaaga gccttcagca tcgggataaa ctgattgtcg ggattttttt gaaaactgat 3397141 aaacaggaga cctgcatcca tatagccggt tttcggatca agtccttctg tgtaagagaa 3397201 agctcttcgc aaaatttgtt tcccagtaga tttcgctaga ctgacgtgtg aattagacgg 3397261 aatttgattc agcttcacgg gatctgtttc ctttttctgc ccaaaaggcg cccccgagct 3397321 ttttctgcgg ccgaaggtat cctcttggtc cttgagggaa gagcggtccc atacctcaag 3397381 gaacattttg attttccgaa aagccatata ggtgccgccc gtcatccagt caggctcacc 3397441 agactgaatc cacacgatcg agttcatcaa cgtgtcatcc ttcgtgctct ggttgcctgt 3397501 tccatcttta aacccgaaga ggttgcgcgg tgtttcacca ttttttccac cgcttaaaaa 3397561 gcctttgttc acaaaacgga cctcacaagt gccgaccgct tgatttagca ggttacgcag 3397621 cgcgtgaaac gccacttgct cgtcgtctgc acacacttga atgcagatgt ccccgcctcc 3397681 ctgcttttca tccaggttgt cattgggcat cgctggaaga gcggctaggt gcttcggttt 3397741 tttgcttttc agtccgaagc ggtcctttcc gtctttttca aaaaagccag gcccgaatcc 3397801 gaatgtgacc gttaagttgg aaggggataa atcagcagac tcacctgtat cctgcggcgg 3397861 cagatactga tttctctgct ccgctgacat tttcttgcca gacgtcagca tctgtgtgag 3397921 acttgtccag tttctaaata acgtaatgat gtcgcttttg tcttttgctg ttacatccag 3397981 tgcagcaaaa tagacatacg tctgatgggc agttgtgatt ccggcctgat gctttccgta 3398041 aaacggaaca atctgctcct cctctttttc atcctttttc gatggcttag ccgcagtctg 3398101 aacaagcgga gcgagaccgc cgagaccgct ggcaccgatc gcaacggctg cccccgccat 3398161 cgctccccat tttaaaatgt cccgtctgtg aatttgttct ggctttttct gttcatcgct 3398221 catgatgtta caaaactcct tttatagcac attcgcaatc ttcgacatgg tttcagaaag 3398281 agtcgtcagc ttagtgctca gctctctgat ttgcttttca cttaatttat cataagacgt 3398341 ataggactga tcatttgttt tgtattttgc cattaaaact tcaaattcgc tgaactccgt 3398401 atccagtttt tccgtcaagt cggagtgatc ttttacaagc gcgcttttca ctgtttgata 3398461 aacggcttcg gagccttcca catttgccat aaggtcaact aaatcaattc gtgagtagcg 3398521 ctcttcttct cccgtgattt tcgaaattcc ggcttcgttc agaagctcca tcgcgcctgc 3398581 aacaatttgt tcaggtgtta atttcagtga ttgaattgaa ccgtcaagct cttttacatc 3398641 cttgagaagc tggtcagctg ttgccttttc cccggaaata tcttgatcct tccaaatggc 3398701 cttctcaagc ttatggaagc ctgtccattt gtctccttct tcaacatcgt tttctcgtgc 3398761 gtcaattttc ggatcaagat ctccgaggct ttcagcgatc ggttcgattc gctcgtaata 3398821 aacacgcgct ttcgcatata acgttttgga cttttcgata tcgccggatt tcacagcacc 3398881 cgtaaatgct tcagtcgctt tgacaagctg gtcactctgc tctttgacat agcctttata 3398941 ctcatccgct gcttttgcca gctgatcgct agcctttttg ccgctcttct tcgcttctgt 3399001 caggtcttct aaggatgctt tcaatgactc ggattctgtc ttgatttttc ctgcatccgg 3399061 tttgtctttt tgcgcttctg tgtagattgg ctgaagatgc ttttcgattt ctgtatattc 3399121 gaatggatag tcgctgcgaa tatcgttttc aaaggaaagc cagtagctgt ttaactcttt 3399181 ccccttcttt tcaatctctt tttggtctcc tttttccact gagtcattca gcttagaaat 3399241 gatggtttcc attttattta cggatgcggt gatttcttta gtgaccccgc ttttttcaga 3399301 tgaagctttt tctttggttg aagatgtgtc attggctccg cagcctgcgc acagcgcaag 3399361 gatgcatccg gctgatacag cgatttttgt gaaattcatt ttgtcagttc ctttccgttt 3399421 gtaaaatgtt ttgccgcttc tgaaacaagc gcaatcagta aaaagagtaa aatcaacatt 3399481 tgcggaatcg tgctgtacac agacggataa attcctagca ccgatacaga cggcagccag 3399541 ctttctgcat cagacggaag aatgcccgcc agttgaaggc tgtgaacgcc ggttccgaga 3399601 aatttcacgc acatatacag gacaaccgcc attgatagaa gaaaaaacgg cttcaatgga 3399661 atgcgcattc cgagcttgat catcagaaca ccgacgatga cgagaacgat aagccctgcg 3399721 gcagttccgc cgatcagttc agtgagcggg agcttcccga caagcccgat gaaaaagatg 3399781 accgtttcga gaccttctct tacaactgcc agaaatgcaa tgagcgcaaa ggaaagcagg 3399841 cttcgttttt ttagtgcctg tgacttctgg atattgattt tttctctcca tttatccatt 3399901 gaggcgtttc tgtgcagcca caccccgaca tacaaaagca tgacagcgga cagtacgccg 3399961 gtaacgccgc caagcaagaa attgttttct ccgaatacac tggaggagaa cagaaccgtg 3400021 acaccgatgc cggctgctaa ggaaacagcc atgccggcgg acgccccgcc ccagatccat 3400081 gtcgaggaac gcgtaacccg cgcttttttt gtcatggtta atagcgctcc gatgacaagg 3400141 agggcctcca ttccttcacg aaccgggatc agcgccgcat cccaccagct gtagctgctt 3400201 gaagcgatcg gctcgagcaa ttgaatcatt tcgtcaattt gctttgatac cttttcagga 3400261 tggctgccga tctccgcctt catcagcgcc agattttcct ccgatgtcgt ataggcttct 3400321 ttcgattggg acacgacatc tccctcaaca gcgagccagg atgtaactaa attgtcgatt 3400381 gcggatgacg cttcatccaa ttgttttttt tctatgaact gttttgtgtc tttcaagctt 3400441 tgtatatagg ctgttaagga cgcccttgat tgacctgagg atgtcttttt cagcacgaca 3400501 gcctgctgat aggtttctaa atgagacgca agctcttcaa gctgtgtttt gagcttacgt 3400561 gcgtcttgat tgataaaaga aagagaaatc atcgcgatat tcgcgtccat ttcactgtga 3400621 gaagaaaggt tttctttctt aatagaaggt tcttcttttt tccacttcgc cttgaaggtg 3400681 tcaaacgttt gttgtgccga atccatatcc ccgtctttta cggatttgat catttgcttg 3400741 tttaattgaa ttaatgcggc gatcggatca tcttccgcat gtgccgcaga accgaaaacc 3400801 atcaacaagc tgaatagaat aagtgccagc ccccgagcca tcatgttcct cctataattg 3400861 aaaatgatta tcattgtata acataatcat agccagttcc tgtcctttgt caattaaaat 3400921 ttgaaggtct gaaaaccttg atggacagca aaaaagctgt ccttttacag aacagccctt 3400981 tgaaggaaaa tgaacgatta tcttcctgtt ttatacgttt gaatttcctc acgaaacttg 3401041 cgtgcagcac tctcaggatc ctccgcctga ctgatggcgc tgatcatact gacgccatcg 3401101 gcccccgctt ggataacagg tgcggcatta tctattgtga ttccgccgat gccgacaatt 3401161 ggaatgctga tgccttggcg gcgcactgct tcgataagag atacaccctg taccgctctc 3401221 gtatcttttt tcgtttcagt cggatagatc ggcccaagcc cgacataatc cgctccgtct 3401281 tcttcggctt gcttcacctc agacatcgta tgggcagaaa cgccgagaat catatcacct 3401341 atggcagctc ttacctcttt cgcatttgcg tcttcctggc cgatgtggat accatcagct 3401401 ttcagattca gagccaattc cacatcatca ttgacaatga acggaacacc agcttcacgg 3401461 caagctgcct gcgctttttc agcaaattta atccgagcct ctcctgtcag cgcatccccg 3401521 cctttttcac ggaactggta cagggtggca ccgcctttta acgctttttg tacaactgta 3401581 acaggatcgg ctttcgtatt gtttgacccc ataatgaagt atacagataa taactctttc 3401641 atcatttccc gagaaatacg agtcatgaga cagtcaccct ttctatagtc gcccattctt 3401701 ggacgtcttg ttcagtaaca gttgaaagct tgttcagcaa ttcaatctga aagcttccag 3401761 ggcctttgtc agccgtctgc tgtgcggcaa gctgagcggc gaccccatac gaagaaatgg 3401821 ccgcaatagc agcaaacaat ggattttctt ccacagcgca aaacgcaccg acgacggaag 3401881 tcagcaggca accggcgcct gtcacttttg tcagcagctt gtggccgtta tgaagggtgt 3401941 atacatgtga cgtgtcggct atgacatcaa cttcaccagt tatcgcaatg accgtgttta 3402001 gcttttgtgc cgcctgctga gccagccgga tgatgtcgcc tccaccttca cccgcatcaa 3402061 cacctttgat cagccaatcg gtcacgccga cggtatgggc aatttccgcc gcatttcctc 3402121 tgattgcagc aaggcgcacc tcacgaatga tgtcacgtgc cgattcagtg cggaacggtg 3402181 ttgctccggc accgacagga tcaagaatga cgggaacgcc atgttcatta gctgattttc 3402241 ccgcgatgat catcgcttcg actgactcct tgctcagtgt tccgatattt aaaacgagtg 3402301 cacccgcaat tttcgccata tcggcgacct cttcttttgc gtacgccata acgggcgatg 3402361 cgccgagcgc gagcaggccg tttgctgtga aattcgttac gacattgttg gttatgctat 3402421 gcaccagtgg gctatgccgg cggacagccg taagacattt tgctgctgat tgtgcatcca 3402481 tatttgcatc atcctttact atcttttttc gggtcccata aatacgattt cgtatgttcg 3402541 agccaagctc tggcggcaaa cgacaagtac ctgtcctttc tccaaataat ggcgaggtgc 3402601 caagggatga ccggatcgac aagcggaatg actttcactt tttccgggtc aaggccgcgg 3402661 cagatccgtt ccggcaaaag cccgatccca aggttggcgg ataccatctc actaataaaa 3402721 tcccattgtg atgtttcata aatgatatgg ggccggaacc cagccttgat acattccgtc 3402781 ataattcggt tgtgcaggac aaaatcctct ctgaagaaaa taaaaggctc gtccttcaac 3402841 tcacgcagct gacattcttt ctcatcagcc agccggtggg aagggtgaac gacaagcatt 3402901 aaggtttctt ttacgattgt aaacgaatga aagatatctt cgtttgcggg aaggaccaca 3402961 acgccgatat caagagagcc gtccccgaca ccttcttgga cttttataga accgtcttcg 3403021 actagctgaa aggtgacatt cggatagttt tcacggaaat cgccgagcac tctggggaaa 3403081 aaccccgatc cgatcatcgg cggcagtcca atccgtacgt gccctttctt gacttccata 3403141 atatcattta attctgacgt caggttttga aatgatttaa tgatttcctg cgcctgcaca 3403201 tacatgctat gaccggcatc agtcagttcc acctgcctgc cgtttcggta aaacagttca 3403261 attccgagct cttcttctaa atttttgatc atttttgata tcgtcggctg agaaacataa 3403321 agggattggg aagccttcgt aaaacttttt aaacgggcga cttccaagaa atatgttaaa 3403381 tggcggatat ccatgcgctt caccctttct atagacaaaa ggaatacttc ttattcttaa 3403441 tatatatttt acctatagag agaccttatg tacaataagt atataaggga ggcatcaata 3403501 tgaaaaaact gttgctaacc gttattcaaa tcgctctgtt atttatattt gctcggctga 3403561 ttaattgggt gacagccctt cttcatataa atattcccgg cagtataata gggattgtga 3403621 ttcttttcac attattgcac tttaacatta tcaagcttga atggatcgag cttggtgcag 3403681 cgtggcttct cggggagctg cttttatttt ttatcccgtc tgccgtcgga gtgattgaat 3403741 acggagacat tatgtcgaaa tttggtgtca gcattctgct tgttgtcatc atcagcacgt 3403801 ttgtcgtgat ggtgtctaca ggaacgctta cacaactcat cgcaaagaga aaggagaaaa 3403861 agcatacgtg ttcatcggaa ttgtaagttt gtttttaacg gttttggtgt atttaggagc 3403921 aaaaaaggta tatcaacgct ttccgcgtgt ttatacgtcg ccgctattgg tgacgcccgc 3403981 tgtattagtc ggtctgctgc tgctggtgaa tgtcccgtac gagtcctata atctcggcgg 3404041 cggattgctg accgatatgc tacagccggc caccgtggca ttcgcgatcc cgttatataa 3404101 atatttccct gttttaaaga aatacgcagt ggaaattatt ttgaatgtgg ccgtcggttc 3404161 atgcatcgcg attatttcta ccgctcttat tgcgaaatgg cttcacctcg gcaccggctt 3404221 aattgacagc ctcgtcccaa gatcagtgac aacgccgatc gcgatgaacg tatctgaaat 3404281 gatcggcggt atgcctgccg tcacagccgt gtttgtgatt ttaaccgctt tgctcggcac 3404341 agtgatcggc ccgatggtca tccgttattt ccgcattgat aacgaaattg cgcggggcgt 3404401 gctgcttggc acaagcgcgc acggagcggg aacgtcaaag gcatttgagc tcagctctgt 3404461 gtccggcacg atttccagcg tgtcgatgat cttagctgcg attatgacgc tttgcgcggc 3404521 gccgtttttg ctttcattta tgtaaaaaac tgtcctctcg agggcagttt tttttatgtg 3404581 cttcccctta ttgaaaagct ggcgaattcc aatataatgt atttgtggat accaaaggag 3404641 gcaccctgat gcacaacttg caggtgaggc ggcattatgc cgcgttaaaa ggattttatt 3404701 tgtttgcttt tctcggtacg ggcagcataa ttcccttact cagtatgtat ttaacgaagg 3404761 aacagcattt aagcggatca caggtcggct tgatcatgtc actgggcccg attgtgatga 3404821 ttttctttca gccgttttgg ggcatgctga gcgactatac gcaaaaaacg aaaggcctgc 3404881 tggcggtttg cacatcaatc acaggcatca ttggattagc ctatattgca tttgacagtt 3404941 tccctctgtt tattttgatt gcggcctgtt ttgcagcctt tcaaagcacg attattccac 3405001 tttcggacag catttcacta aggtacacac aagaaacaaa cggcaactac ggcggaatcc 3405061 gcctgtttgg ttctctcggc ttcggtgtcg cggtgtttgc catgggacag gtgacgaacc 3405121 agctgtaccc cattcacgtg atctttatct ttggctgtgc ctttctgtgc attgctgcca 3405181 tattggcttc acaagtgccc ggccagcaga aaacaacaaa ggtcaatatc cgcaaaggat 3405241 tccgggagct tatcagcaac aaaactttcc tcatctttat gatcatcacc tttacgacat 3405301 ttgctccaaa cttagcgaac aatacgtatt tcagtctttt tctggacaaa agcggcgcgt 3405361 cactttccgc tatcggcatt ttatttttca tcggtgtcat ttcagaaatt ccatttatga 3405421 gattcgccca aacatttata gataaaatgg ggctgctcaa cgtcattatg ctgtcaggcg 3405481 gagtctcatt attcaggtgg gcgctctatt tcacggcgcc ttcactatgg atcatttatg 3405541 cgacggtctt tcttcaggga gtggccatcg gtttatttat cccggcggcg cttcaatatg 3405601 tgaaaaagat taccccaaga cacgttgaag cgacggcgct gaccatgtac gccgccattg 3405661 gcaacgggtt cggcaactgg ttctgcacat ttgcaggcgg gtacattttt gactacgtgt 3405721 cgatcttcgc agtctacttg ctttttggca ttctgagcat agcaggcttt ggcctgacat 3405781 tatatttaat gaaggctgaa aaaaacaaac atacacttca tcagccggct gttactttta 3405841 aaccataatg actataatga acaaaagaaa ggatgtgcgt tatgaacggg caagagcgaa 3405901 acagcatttc gaaagggttg caggttgata ttgtattgaa agcagatcaa aaaacaggaa 3405961 aactgacgag agggacagtg aaggatattt tgacgaaatc aaactttcat ccgcatggca 3406021 ttaaagtccg tcttgaagat ggccgcatcg gccgcgacca gcagatcgtt tctacataaa 3406081 aaaaagctgc ccctgaacag ggcagctttt tcattatttt ttctgcagaa ggaccacttt 3406141 caggtagttg ccttccggaa atgccgaaat cgttttgaaa tcctccggca gcgtaaattc 3406201 ctcaatgatc gtgtagcgtt catttgtttc tttaaaggcg gcatcaataa agcctttgaa 3406261 cttcttcatg ccaaaggcgc tgctgtttgt agaggcaaca atgacaccct tgtcagcagt 3406321 gatggcgatc gtttccttca gcaggttttt ataatccttg gccgcgctga aggtgcgttt 3406381 ttttgtgcgc gcaaaggaag gcggatctag aataatcaga tcaaagcgca aatccttttt 3406441 tgcagcatat gaaaaatagt taaaaacgtc catcacttta atgtcgtgcg cttcgtaatc 3406501 cagcttgttc acgctgaatt gctcgatcgt tttggcaaga cttcgatttg ccacgtcgac 3406561 gcttgttgtt ttctccgctc cgccaagcgc cgccgccacg gagaatgcac ccgtataaga 3406621 aaacgtattt aaaacggttt tcccttttgc atagcggtct ctgatcgcct tgcgcacatg 3406681 tctctgatcc aaaaagatgc ccgtcatggc gccttcattc agatccaccg cgtattgaat 3406741 gccattctct tggatgatga tcgggaactc gccccttctc cctttcacga agtcatcatc 3406801 ttcaacgtat tgtccagccg tgtcgaagcg tttcttctcg taaatcgctt tataatcaag 3406861 atccatctca tccaatgcgg aaatcagcat gtctttaaag gtgtaaattc ccttgctgta 3406921 ccattgaatc agcaggtagc cgtcataata gtcgatggtg acgccgccga caccgtcacc 3406981 ctcaccgttg aacaggcgga aagctgttgt atcttgagcc tcaaatagtt tggcgcgcgc 3407041 ttgggccgct tttgttaatt tgctgagaaa aaatgcttgg tcaatctgtt catgtttatt 3407101 gcgggtaagc gtccagccaa cccctttgtt ttgcaggccg taatagcccc gcgcgagaaa 3407161 ctcgccgccg ctctcagaca cgatatcaac gaggtctcct tctttcatgt gccccgcact 3407221 ccctgcgaga gcttcttttt caataagggg atagcctttt tttattttgg cagcgtgtgc 3407281 tttttttagg gtgagtagct tcatatatgt cgtcctcttt ccgtttgctt tctcttatgg 3407341 taccacaaaa cgccaagatg tctgcattga cagaaaggaa aggtttttct acgatagaca 3407401 aaaagagtta cgaggaggag cagcatggca aaacgaattg accatacagg catcatggta 3407461 agagatatta acgcgtccat cacattttat gaagaggtac taggcatgaa attgaaggat 3407521 cgcatcactc acacgaacgg tgtaatcgag cttgcttttc ttggctttga agacggcccg 3407581 gaaacagaaa ttgaactgat tcaaggctac agcagcgagc ttcccgctga aggaaaagtg 3407641 caccacattg ccctgctgac ggatgacatc gcggctgaat atacaaaagc ggaaaaaatg 3407701 aacgcaaaat ttatcgacga ggagatcaca acacttccaa acggataccg ttatttctat 3407761 atcgaaggcc ctgacggtga gtggattgag ttctttcagc ggtaaaaata aagaacgtac 3407821 attttgtgat gtacgttctt ttttatctat accaactgat atacgttgac tcatcgcaaa 3407881 tcatagcttc ccagcccata cgctcaacca attcatggat gtttttatct ttggctaaaa 3407941 agacattaat gaatgagtca tatacactca taaacacaaa atccattttc tcatcagtta 3408001 aaacgagctc tgttgcggct tcatcaagaa ccgtccgcaa gttggcttca gttatgtcca 3408061 aaacgccgcg gttttccaca atcggttctg cgtaataaaa ccgattggat ccgttcgcac 3408121 ctaatacctt taccaaactc ggaatatgaa aatttgaaat atgatcctca ctgggataat 3408181 agaggtctcc atttatgttt tcatgtaaca cctcagccaa atcctctctc gcgaactcgt 3408241 cccttaaagc gcctatcgac gtcattaaag ccagcgccag ctcagcatgt gtttgaaagc 3408301 cgcaagaaga cataaccttc ttccaggaaa cagccttgcc tattcctctt atttcattat 3408361 cgtttggata aatatgttca taatcatttt ttctttttgc attctcccat ccttcaggca 3408421 tttggataaa aggagaaaag ataagagcag cagatgagta ttcaactggt acttgttgta 3408481 agattggtga ttcgtcatct aaccatatat aatctagcat gcgcacctcc tttacatatt 3408541 ctaacattcc tttcgtttga aagagatgat cagccctatg acaggctgat catctatcac 3408601 atcacatttt tatccccaga ttcaaccgca ctctcttccc gccatttttg atgatcccat 3408661 attctgaaaa acggatagta gatagcacag gtgatcagca gatttaccag ctgcataact 3408721 gcgcccgaca cctttccgcc tgtcgccagg taacctgata tgagcggcgg catcgtccat 3408781 ggcaccgcga ttccggccgg tcttgccacc agcccggtgc tcatgccgat ataagtcgcg 3408841 gtaatcgtga ggagcggtgc gatgataaat gggacaataa ggaggggatt catgacaatc 3408901 ggcatgccga aaatgatcgg ctcgttgata ttaaatagcg cagggccgat tcctaatcgt 3408961 ccaagctgct tcatttgttt gctgcgggag cgcacaagca tcgtcaggac aagcgccagc 3409021 gtcgccccgc ttccgccgac attgatccaa atttgaaaaa actgagtcgt aaaaatactc 3409081 ggcagcgcct cgcctgcttg gaaggcgaga cggttggcat ccatcgcgcc gtaccaaatc 3409141 ggcgccatga ttccgccaat gatggaagcc ccgtgaatcc cgcacgacca aagcagcatc 3409201 tgcacaaatt cagcgatcag gcttccgccg agactgccgc caaggatgga aagcggtgtg 3409261 ccaagcaggt ctcctacgac attgtgcaga ctctgaaaag gtgtcatttc aatcagaaga 3409321 cgcgccagcc atacgagaag cacaatgata aagccgggaa tcagcgcgac aaatgatttg 3409381 cttaccgcag gcggcacacc gtctggcatt ttgaagacga tatttttttg aataatgtac 3409441 cgatagattt cggttgaaaa caaggcgatc agcatggcga caaataagcc cttgctgccg 3409501 agcagcgtga tcgggattcc gccccctacc atgatggact ccgttgagcc atgcggtgta 3409561 aacggcacct caaacggtgt tgccagcaga aatgcggcaa ttgaaatcgc tccggcagaa 3409621 agggcatcga caccatagct ttctgccagc cgataggcga tcccaaaagc ggcaatcatc 3409681 gccataatat caaacgaagc gttaacagga tatccgagct tatcggccca ctcgttccca 3409741 aacacactcg ccatgaaatc agcatacccc ggaatcggca agctcgttaa aatcaagaag 3409801 acagacccga taataatcag cggcatggtc aggataattc cgtcacgcaa agcgctgaga 3409861 tgccgctgcc cggcaatttt cccggcgaca ggcattattt tttcctccat cacccgagtg 3409921 aatgtgctca tcttaaaaac ccccttttct cattgctttg tgaacaacct ccgcaatgtt 3409981 ttctttatct tattttgaaa acgcttacaa attcatttgg aaaatttcct cttcatgcgg 3410041 aaaaaatctg cattttgcta aacaaccctg cccatgaaaa attttttcct tcttactatt 3410101 aatctctctt tttttctccg atatatatat caaacatcat agaaaaagga gatgaatcat 3410161 gaaaaacatg tcttgcaaac ttgttgtatc agtcactctg tttttcagtt ttctcaccat 3410221 aggccctctc gctcatgcgc aaaacagcag cgagaaagag gttattgtgg tttataaaaa 3410281 caaggccgga aaggaaacca tcctggacag tgatgctgat gttgaacagc agtataagca 3410341 tcttcccgcg gtagcggtca cagcagacca ggagacagta aaagaattaa agcaggatcc 3410401 tgatattttg tatgtagaaa acaacgtatc atttaccgca gcagacagca cggatttcaa 3410461 agtgctgtca gacggcactg acacctctga caactttgag caatggaacc ttgagcccat 3410521 tcaggtgaaa caggcttgga aggcaggact gacaggaaaa aatatcaaaa ttgccgtcat 3410581 tgacagcggg atctcccccc acgatgacct gtcgattgcc ggcgggtatt cagctgtcag 3410641 ttatacctct tcttacaaag atgataacgg ccacggaaca catgtcgcag ggattatcgg 3410701 agccaagcat aacggctacg gaattgacgg catcgcaccg gaagcacaaa tatacgcggt 3410761 taaagcgctt gatcagaacg gctcggggga tcttcaaagt cttctccaag gaattgactg 3410821 gtcgatcgca aacaggatgg acatcgtcaa tatgagcctt ggcacgacgt cagacagcaa 3410881 aatccttcat gacgccgtga acaaagcata tgaacaaggt gttctgcttg ttgccgcaag 3410941 cggtaacgac ggaaacggca agccagtgaa ttatccggcg gcatacagca gtgtcgttgc 3411001 ggtttcagca acaaacgaaa agaatcagct tgcctccttt tcaacaactg gagatgaagt 3411061 tgaattttca gcaccgggga caaacatcac aagcacttac ttaaaccagt attatgcaac 3411121 gggaagcgga acatcccaag cgacaccgca cgccgctgcc atgtttgcct tgttaaaaca 3411181 gcgtgatcct gccgagacaa acgtccagct tcgcgaggaa atgcggaaaa acatcgttga 3411241 tcttggtacc gcaggccgcg atcagcaatt tggctacggc ttaatccagt ataaagcaca 3411301 ggcaacagat tcagcgtacg cggcagcaga gcaagcggtg aaaaaagcgg aacaaacaaa 3411361 agcacaaatc gatatcaaca aagcgcgaga actcatcagc cagctgccga actccgacgc 3411421 caaaactgcc ctgcacaaaa gactggataa agtacagtca tacagaaatg taaaagatgc 3411481 gaaagacaaa gtcgcaaagg cagaaaaata taaaacacag caaaccgttg acacagcaca 3411541 aactgccatc aacaagctgc caaacggaac agacaaaaag aaccttcaaa aacgcttaga 3411601 ccaagtaaaa cgatacatcg cgtcaaagca agcgaaagac aaagttgcga aagcggaaaa 3411661 aagcaaaaag aaaacagatg tggacagcgc acaatcagca attggcaagc tgcctgcaag 3411721 ttcagaaaaa acgtccctgc agaaacgcct taacaaagtg aagagcacca atttgaagac 3411781 ggcacagcaa tccgtatctg cggctgaaaa gaaatcaact gatgcaaatg cggcaaaagc 3411841 acaatcagcc gtcaatcagc ttcaagcagg caaggacaaa acggcattgc aaaaacggtt 3411901 agacaaagtg aagaaaaagg tggcggcggc tgaagcaaaa aaagtggaaa ctgcaaaggc 3411961 aaaagtgaag aaagcggaaa aagacaaaac aaagaaatca aagacatccg ctcagtctgc 3412021 agtgaatcaa ttaaaagcat ccaatgaaaa aacaaagctg caaaaacggc tgaacgccgt 3412081 caaaccgaaa aagtaaccaa aaacctttaa gatttgcatt ccaagtctta aaggtttttt 3412141 tcattctaag aacaccacac acaacctttt tcccatccat tgtacaggct tttcatacta 3412201 ttgctataca gccatgaaca gcataaaatg aacgttatta cagttatcac cacatatggc 3412261 gggattgtga ctgggcaggc aggcaagacc caatgatgca aagggagtat taatgcctaa 3412321 aaaacagggc attttaactc ttcttttcgt gttgggctca taacggcgcc ttggacaacc 3412381 ccctattctc atgctccgtc gtcgacgcgg gcatttttgt cattttcagc cggtatttct 3412441 cacttttttc attttgattg tcaacttttc atttgatacg atgaacaagc cgacttttct 3412501 tcagcaaagg aggttttaat tgcttgcata aagagattgc aaaagaatta ctgctgctcg 3412561 caggaggaaa aaacaatatt atcagcatca gccattgtac gacccgtctt cgttttgatg 3412621 taaaggacga gacgaaaatt gatatacatg ccattgagaa cctgcaaggt gtgcagggca 3412681 cctttttccg ctatgggctt ttccagatta tcttcggagc aggcgtcgtc aacaaaatat 3412741 ataaagaagt cgttcatgta tgggagaccg cgccttctga agagcctgtc caccagaaaa 3412801 aagccagccg gaagctgaac cctgccgcag cttttgcgaa aacactgtcc gatatttttg 3412861 tgccgattat tccggcaata acagcaagcg gcctgctcat ggggctgatc ggcatgatta 3412921 aggtgtttca ttggttcgct gccggcagcc catggattaa aatgctcgac ctcgtgtcca 3412981 gcacagcctt tattttactg ccgattttag tcggcttcag tgctgcacgg caatttggca 3413041 gcaacccata cctaggggca gtgattgcag ggcttttgac gcatcctgat ctgctggacc 3413101 cgtctatgct cggcagcaaa accccgtctt ctttagacat atgggggctt catatcccaa 3413161 tgatgggcta tcagggttcc atgataccga ttcttctttc cgtttttgtc atgagcaaaa 3413221 ttgagaagct attaaaatcg attgtgccga agtcgcttga tgtcgtgatc attcccttta 3413281 ttacggtcat ggtgacaggg tgcctcgcgc tgattgtgat gaatcccgcc gcgtccatca 3413341 tcggccagat catgacacaa tcgatcgtct atatttatga tcacgccggc attgctgccg 3413401 gagctctttt cggcggcatc tactccacca tcgtcctatc tggattgcat catagctttt 3413461 atgcaattga ggcaacgctg cttgctaatc cgcatgtcgg tgtcaacttt ttagtgccga 3413521 tatggtcgat ggcgaatgtg gcccaaggcg gagcggggct tgcggtattc ctcaaaacga 3413581 aacaatcaag cctgaagaaa attgcgctcc ccgcttctct gaccgcgttt ttaggcattg 3413641 ttgagccgat tgtattcggg gtaaatctca aattgatccg tccctttatc ggagcagcca 3413701 tcggcggtgc tattggcgga gcatacgtgg ttgcggtaca agttgtggca aattcctacg 3413761 gactgacagg cattccgatg atttcaatcg tgctgccgtt tggcgccgct aattttgttc 3413821 attatatgat cggtttcttg atcgcagccg tctctgcttt tatagctaca ttgtttctcg 3413881 ggtttaaaga agagacagaa taactggatt tattcgattt cattcataaa acgggggatg 3413941 aaaggacaaa aaagctatga aaattaaaag aatcttaaat cataatgcta tcgtcgtaaa 3414001 ggatcaaaat gaagagaaga ttctcttggg tgcaggaatt gcgtttaaca aaaagaagaa 3414061 tgatattgtc gatccgtcaa aaatagaaaa aacctttatc agaaaagata cacctgacta 3414121 taagcagttc gaagagattt tagaaacatt gcctgaagac cacattcaga tttctgagca 3414181 aattatctct catgccgaaa aagagctgaa catcaaaatc aacgagcgca ttcatgtcgc 3414241 tttttcagac catctttctt ttgcaattga acgcctgagc aatgggatgg ttatcaaaaa 3414301 tccgctgctg aatgaaatca aagtccttta tccaaaggag ttccagatcg gcttatgggc 3414361 cagagcactg attaaagata aactggggat tcacattcct gatgatgaaa tcggcaatat 3414421 cgccatgcat atccacacag caagaaacaa tgccggcgat atgacacaaa cgcttgatat 3414481 tacaacaatg atccgtgata ttatcgagat tatcgaaatt caactgtcta ttaatatcgt 3414541 tgaagatacc atctcttatg aaaggctcgt gacccatctc cgctttgcca ttcagcatat 3414601 caaagcaggc gaatccattt acgagctgga cgcagaaatg attgacatca ttaaagagaa 3414661 gtttaaggat gccttcctgt gtgccctaag catcggcacc tttgtgaaga aggaatacgg 3414721 ctttgagttt cctgaaaaag aattgtgcta catcgccatg catattcagc ggttctacca 3414781 acggtcagtc gcacgctgag acaaacaaaa aacgcttttg atcatctcaa aagcgttttt 3414841 ttatctgatt tattggttga tcgccggatt cccaatcgta ttccacttcg tataggacat 3414901 gtaatggaaa tactcatcgc gatacggatg ttttgtattg gagttccaag gcttttctcc 3414961 gccgcagaag tgcacgattg ccgggttttc tcttgtttca ttatattgct tccgccctaa 3415021 cagagtcgat ggggttttca gctttaacat gatataggtt tgagcgttcc agcgcggatg 3415081 aagttcatac cactgatcat acaagatcgc attcagtgca tcttggtcat gcagcacaag 3415141 aaagtcttcg tctgggtgtt cattgataaa gttgatgact ttttctgtga tgttttgctt 3415201 tctccaagac tcaaaatcaa taatcatgat acctgagtta aaatacttcc ctgtatcagt 3415261 gacgttcatt tctttcaggc gttcatgctg ccccgcatcc tcaacagcgg ctacggtgta 3415321 tggcgcaatg tctaagtccc atagcttaga aatatcctct aggacaagcg catcacaatc 3415381 gatgtaaatc attcgtttga tgctttcatc cttaattaag tcgggaatcg aaatgcggta 3415441 atacgcggct tttgtaatat ggctgctctc aaccgcatgt tcatacatgt tggtatccac 3415501 ttctaaaaac tcaatcggca ctccgaattt caaagtggtt tcttccagtc tttttttgtt 3415561 atcaggctta attccgccat caatgacgta taattttacc tctctctcct gatccatgtt 3415621 agtcaataaa gaaacgaaca tcccacctaa atgacgagca taattatcat ctgcgcatga 3415681 tacgatatgc atgatttcat ctttcctcaa tggtattcat ctcccttttt gttgtacaag 3415741 ttacataccc tttttcaaaa aaataaacac gttctccgac atttttttaa acagaatgtg 3415801 tgatacaaca aaaaaggtgt cattttttga agatgcgata aagccaataa agaatgaaaa 3415861 agcttgcgat tgtgatggct tcagccgaga cgatatacca cggccatggc ccgagaacat 3415921 ctaagagaga ggaaccgccc ggttttttcg tcaaatacat ataattcgcg ccaagccagc 3415981 gatcaatcag aaaaatacag acgccgtaca cattaacaag caggactgtc acccataacg 3416041 agcgctggcc cattctgtag gtgccaatca cagccatcag cagacaggat aaaaacacag 3416101 acccgtgaga aataaaaaag aggatatatc ggatatgcgg aaatgaaaac ataccgaggt 3416161 caggagtggc aagagcctga atcgaactgc cgatgccgac aaaaaacaaa aacacaaaca 3416221 gctttctgct ttttgtcact aacataatag ctgacaaata caccgacagg tcactaagct 3416281 ggagaggcaa tgaagtgcgc accgaccacc tgtccgtggc gaccatccat atttgatagc 3416341 cgatttgcga accaagcaaa agaaacacaa acagagaacg caaaaaccgg ctggccctcg 3416401 gctgcttgac ctcatcttgg aacaaaaaca acagaatggc caaaagggag ataatcgcta 3416461 acgtcactac atgctctgtc gaaaacagat gaaacggatc atgcttatag tcggattgaa 3416521 catatttttg caaaactgca cccccgtttt cgggtttttg tttattttgg cgttgtttgg 3416581 gcttttttta ttcaaccgat atatgggctt gaagttcaca ccagactctg ttaaaattcg 3416641 tttcatagct aatgattctg ataatttaag gcaggcctaa aaaatggaac gttcacatca 3416701 acatcagcag cttcggaagg aagaacacga tacactttct aagctcaaac aaatgcccgt 3416761 cgagtcactc aacctggaag ccatttcgat cgctacgaat ctgtatcggt ctgcacaaag 3416821 gctccgtgtc aaaatggaga ctgaggttct ttctacctat aacctttctt ggaccgcttt 3416881 ctccattctt tatgatctat gggtatgggg agcgctcgaa acgagaaaaa tcgctgagct 3416941 gtcagggata tctacagcta cagcaagcaa cgtgatcaaa acgctcgaaa aaaagagttt 3417001 ttgccgtaaa agcatcgaca caagagatcg gcgactcgtg tttgtctcaa tcaccgattc 3417061 cggcaaacaa gcgatcgaag aactctaccc ggagtttcac aaaggggaaa cagagctcat 3417121 tgcgggaatg acgaaggacg aacagaaaat attgacaggg ctgcttagaa aggtagctga 3417181 caatcttcat acaacataag ctttgacggg aatccagtag cggtttgtct ccctgtttca 3417241 gagagccggc ggtaggtgcg agccggcgca caggcaaacg tgaattacct ccccaagctt 3417301 tctttgtgaa ccttagtagc aaagaacggg aaaccgttat tcgaatgagc ggaagacaat 3417361 gtcttcaacc agggtggtac cgcgtgcatt gagccacgtc ccttattggg atgggctctt 3417421 ttttgtgttt gtaaaaaagg aggaaaaatg atgagaacat ttgagcagct cacagcgtca 3417481 caacaaaaag aggtagaaag acagcttcag ctatacatga caggcgccca cgaagtcata 3417541 ccgccggagg aattaaaggc aaagctcgtg aaatcaattt ccacgggcac gccgcttaaa 3417601 attaagctcg gattagatcc gtctgcaccg gatgtacatt tgggccatac ggttgtgtta 3417661 aataagcttc gccaatttca agaaaacggc cacattgtcc agctgttaat tggggatttc 3417721 acaggaaaaa ttggtgatcc gaccggaaaa tcggcagcca gaaagcaact gactgatgaa 3417781 gaagttcagc acaatgccaa aacctacttt gagcaattcg gaaaagtgct tgatccagaa 3417841 aaagtcgagc ttcactataa ctcaaaatgg ctgaaaacat tgaatctaga agatgtcatt 3417901 gaattagcag ggaaaataac ggtagcccgc ctgatggagc gcgacgactt tgaagaacgc 3417961 atcgccatgc aaaaaccaat ctcactgcat gaattctttt acccattgat gcagggctat 3418021 gattctgtcg ttctcgaaag tgatattgaa ttaggcggaa cggatcagca tttcaatgtc 3418081 ctcatgggac ggcatttcca agaacgatac aacaaagaaa aacaagtcgt catccttatg 3418141 ccgctcttgg aaggcttgga tggcgtcgag aaaatgtcga agtcgaaaca caactacatt 3418201 ggcattaacg aacatccaaa cgacatgtac ggaaaaacga tgtcactgcc cgacagcctg 3418261 atgaaaaagt acatccactt ggcgacagac ttagagcttg aagagaaaaa acagctcgta 3418321 aaagacttag aaaccggcgc cgttcatccg cgtgatgcca aaatgctttt agccagaaca 3418381 atcgtccgaa tgtatcacgg agagaaagca gcagaagctg ccgaacactc gtttaaaaca 3418441 gtctttcagg aaaacagcct gccggaagat ataccggccg taaactggaa aggcgaaaaa 3418501 acgatagcga tgattgatct gctcgtcaag ctaaagctcc tctcttcgaa gagcgaggcg 3418561 cgccgcatga ttcaaaacgg aggtgtacgc atcgacggag agaaagtaac agatgttcac 3418621 gccaaagcag agataagaga gaatatgatc atccaagtcg gcaaacgcaa gtttttaaag 3418681 ctccaataat ctgatattcc gaaacgctta tgacccttca ttcataagcg tttttttgca 3418741 ggtataaagc actgtctttt caaaaacgct ctccatcttg caggaaactc ctttagcatc 3418801 ccgaaatatt ccccaaccat acatttaggg gaggtttatt tttgatgaaa aagcttttga 3418861 ctgtcatgac gatggctgtt ttaactgccg gcacactgct cttgccggca cagagtgtca 3418921 cccctgccgc gcacgctgta caaatatcaa atagcgagcg cgagcttcca ttcaaagcaa 3418981 aacatgcgta ctctaccatt tctcagctaa gtgaagcaat cggccccaga atagccggaa 3419041 ctgcagctga aaaaaagagt gccctattga tcgcctcatc aatgagaaaa ttaaagcttg 3419101 atgtgaaggt tcaacgattc aacattcctg accggcttga gggtacactg tcttcagcag 3419161 gacgcgatat tcttctccaa gcggcgtcgg gctcagctcc gactgaggaa caagggctga 3419221 cggccccgct ttacaatgcg ggattgggct atcaaaagga ctttaccgct gacgccaagg 3419281 gcaaaatcgc cttgatttcc agaggagacc tgacttatta cgagaaagcc aaaaatgccg 3419341 aagccgccgg agcgaaagct gtcatcattt ataacaacaa agaaagcctc gtgcctatga 3419401 cgccaaacct gtcgggaaat aaagtcggca ttccggtcgt cggcattaag aaagaagacg 3419461 gcgaagcact tacccagcaa aaagaagcca ccttaaaact aaaagcattc acaaaccaaa 3419521 cctcccagaa tatcatcgga atcaaaaaac caaagaacat caaacatcca gacattgtgt 3419581 acgtgaccgc ccattacgac agtgttcctt tttcgcccgg agcaaatgac aacggctcag 3419641 gtacctctgt tatgctggag atggcgcgtg tcttaaaaag cgttccatct gataaagaaa 3419701 tccgctttat cgctttcggc gccgaagagc tcggcctgct cggctcctct cactatgtag 3419761 atcatctatc ggaaaaagag ctgaaacgaa gcgaagtgaa cttcaactta gatatggtag 3419821 gcacaagctg ggaaaaagcg tctgagctgt atgtcaacac attggatggc caatctaact 3419881 atgtttggga atccagccgt acggctgctg aaaaaattgg gtttgacagc ctgtctctga 3419941 cacagggagg atcatctgat catgtgccat tccacgaagc cggcattgat tccgctaact 3420001 ttatttgggg agacccggaa acagaagaag ttgagccgtg gtatcatacc cctgaagact 3420061 cgatcgaaca tatcagcaaa gaacgcctcc agcaagcagg cgatcttgtg acagccgctg 3420121 tctatgaggc tgtgaaaaaa gagaagaaac cgaaaaccat taagaaacaa atgaaggcga 3420181 aagcatctga catttttgaa gatatcaaat aaaaaaagac ggcacttggg tgccgtcttt 3420241 tttaatccac ttctttctta atccccagca ttttctcatc taggtaatgg gcaatctccg 3420301 cggcttcttt cagctcatct gttaattgct taggaacgtc attgttcaat ttataataaa 3420361 ttttatgttc aaggctcgcc cagaaatcca tcgcgattgt ccggatttga atttctgctt 3420421 tgacgtattc cacacggttc gttaaattca caggcatctc aatgattaaa tgcaggcttc 3420481 gatagccatt cggtttgggt gtctggatat aatcctttac ctttacgatt ctcaaatctt 3420541 catgctgctt caacacattc acgacattat aaatgtcaga aataaaggaa cagatgatgc 3420601 gcacgccggc aatgtcgtga atatgctcct tcatttcctt cgtcgtaatc tcacagccct 3420661 ttctcattaa cttattcacg atgctttcaa agctttttac acgggatttt gtatgttcaa 3420721 tcgggttgtg tccgtgaatg aggttatatt cctggctgat aattgagaac tttgtatcga 3420781 gcgcatctag cgcaaattta taaactaata actcattttt ccaatcttcc attactgttt 3420841 ttaaatcgtc catatgtgtt acagataaat ccatgttcgt catctccttt aacggaactt 3420901 tatccgctgt ccatgtacta gacgtccctg tctgctgcaa ggttctatga atttttttac 3420961 aaaatgcggt cgattgtaac aaaaaaagac cgcatgaaac gagcggtctt ttttattatc 3421021 ggaaatagct gatcaataat ccgatcgaga gcaggaatcc gaaaaatgta tttgtttggg 3421081 ctgttgattt cattgcgaca atcatattca tcggcatttc gttctggacg aagcccttca 3421141 ctgcctgaac cggcttaggc acgctcaaaa agacgacaaa cagccatggg cttgcggcac 3421201 cggtaataac caagccgaca acccagatat aagcgacggc aaacgacgca gctaacagag 3421261 taacagctcc cttatgcccc atcaaaatcg ccaatgtttt gcgtccgcct tttttgtcct 3421321 cttcaatatc acgaatgttg ttcgacaggt taatcgcgcc gacaagaatc gcaatcggga 3421381 tggaaatcaa aatgctctgc atattgatct tatctgtctg aatgaaaaac gaaatcagca 3421441 caaacaccga acccatgcaa atgcctgaga ataattcacc gaacggcgtg tacgcaatcg 3421501 gcagcggccc gcctgtatac aggtagccga tcgccatgcc gacaaggccg atcagcgcaa 3421561 gccaccagct gctgctggca caaatataga caccgagcaa aatggcaatc ccgtatgagg 3421621 caagagctaa ttgcaaaatc gttttaggct tcattccgtg gcgtacaatg gcccctccga 3421681 ttccgactga ttctgctgta tctaatccgc gtttaaaatc atagtattca ttaaataagt 3421741 tcgtcgcgat ctggatccat aggcaagaaa acagcatagc caaaaacagc agcagatcaa 3421801 ccttcacata aaacatcgcc aaaacggttc cgagcagcac aggcacaaac gatgcggtta 3421861 acgtatgagg acgggttaac tgccaaagga tctgccccat gctttctttt tgcggcgctg 3421921 tctgaccctc acccttattt gtttggttca tcttcctctt cctttctatt aaaaggctta 3421981 ctttttttca gccggcagct taataaaaaa ctccttttgc ttccttatct atcataatga 3422041 cttctccctt atttcacaag ataccgcaag aaggcgtttt ctttcttatt atacgcttct 3422101 cgccctgatt tcattaggtt tctgctttca cttgaacgaa caggtacaga aaaatttttt 3422161 taagtacatt acacttttta aaagttaaaa agatcttttg actccaggta tcttttcctt 3422221 tattatgaat cagctcgaaa cattccattc ttgcccttgc aggtataaag attcattttc 3422281 aaaaacatac gccgatatat taatttgagg gagattaggg aaaaaatgaa actttttgag 3422341 catctgatcg tcaaataatc atgtgattgt cgaaaaaacg ggaagggaat ttttgatatg 3422401 ctgcaattaa tgaaacagct gtatgaaaaa cccgctgtca agtggacatg tcatacaggc 3422461 ttttatttga tgatactgct tgttttgttt tttatgtatg gttttcacac cgcgaatacc 3422521 ggttcatata tttataacga tttctaattg gagagagaat aactatgaaa cttttacatg 3422581 ctattcaaac acatgcggaa acttatccgc aaaccgatgc cttccgctct caaggccagt 3422641 cgctcacgta tcaggaatta tgggagcagt ctgaccgcgc ggctgccgcg atccaaaaac 3422701 gcatttctgg ggaaaagaaa tctcctatcc ttgtgtacgg ccacatggag ccgcacatga 3422761 tcgtttcctt cttgggaagt gtcaaagcgg gacatcctta tattccggtt gacctgtcta 3422821 ttccgtccga acggattgcg aaaattatcg aaagctctgg agcagaattg ctgatccatg 3422881 cagcaggact ctcaattgat gcagtcggcc agcagattca gacagtttct gcggaagaac 3422941 tgctggaaaa cgaaggcggc tctgtcagcc aagatcaatg ggtcaaagaa cacgaaacgt 3423001 tttatatcat ttacacttcc gggagcacag gaaatccgaa aggcgtgcag atttccgctg 3423061 cgaaccttca aagcttcaca gactggattt gtgcagactt tccagtcagc ggaggaaaaa 3423121 tatttttaaa ccaagcgccg ttctcatttg atttgtctgt catggaccta tatccgtgcc 3423181 ttcaatcagg cgggacttta cattgcgtga caaaggatgc tgtgaataag ccgaaagtct 3423241 tatttgaaga gctgaagaag tccgggctga atgtgtggac atcaacacct tcctttgtgc 3423301 aaatgtgcct gatggatccg ggtttttcac aggatctgct gcctcatgcg gacacattta 3423361 tgttttgcgg agaggttctt ccggtttctg tggccaaagc gctgcttgag cgttttccga 3423421 aagcgaagat ttttaatacg tacggcccga ctgaagcgac agtggctgtc acatcggttg 3423481 aaattacgaa tgacgtcatc agccgcagcg aatcgcttcc agtgggcttc gccaaaccag 3423541 atatgaacat tttcattatg gatgaagagg gacagccgct tcctgaggga gaaaaaggag 3423601 aaatcgtcat tgcagggccg agtgtaagcc gaggctacct tggtgagcca gagctgacgg 3423661 aaaaagcgtt tttctctcat gaaggccagt gggcataccg aactggcgat gccggcttta 3423721 ttcaagacgg tcagattttc tgccaaggac gtttggattt tcagattaaa cttcacggct 3423781 atcgaatgga gctggaggaa atcgagttcc atgtcagaca gtcacagtac gttcgttctg 3423841 ctgtcgtgat tccttatcag ccaaacggaa cagttgagta tctgatcgct gctattgtgc 3423901 ctgaggagca tgagttcgag aaggaattcc agctgacaag cgctattaaa aaagagcttg 3423961 ccgcttctct tccggcatat atgatcccga gaaaatttat ctatcaggat cacattcaaa 3424021 tgacggctaa cggcaaaatt gaccgaaaac gcattggcga agaggttctt gtatgacgcc 3424081 ttacagctcg tttttattct ttatactgct tggcattctt cttctgccga cgatcattct 3424141 cggcttaaac ggaaaaagat ttcaagcata caacatgttc atatctatca ttatattggc 3424201 tttaattttt tcgcacgact tacacggggt catcgcgctg tgcctgttta caatatggca 3424261 ggtgctcctg atcagcggct atctggcata ccggcagaaa gcgaacagcg gctttgtctt 3424321 ttgcggagct gttatcgcgt ctattctgcc tttatttctg tcaaaaatat ggccgtttct 3424381 ttcacacccg cagccgcatc atccgccgca taacctgatc agctttttag ggatttcata 3424441 tttaaccttt aaaggcgttc agctgattat ggaagcaaga gacggactgc tgaaagaaca 3424501 gctgccattg caccgtctgc tgtatttcat cctgtttttc ccgacgattt cctccggccc 3424561 gatcgacaga taccgccggt tcgtcaagga tgaacagaag gcttggacga aagaagaata 3424621 cgccgacctg ctgtatacgg gaatccataa aatcttcatc ggtttcctgt ataaatttat 3424681 tatcggctac gcgatcaata cgtacttcat catgaatctt cccgcaatca cgcacaataa 3424741 gattcttggg aacctgctgt acatgtacgg ctacagcatg tatttattct ttgatttcgc 3424801 cggctacacg atgtttgccg tcggggtcag ctacattatg ggcattaaat caccagaaaa 3424861 ctttaataaa ccgtttatca gtaaaaatat taaagatttc tggaatcgct ggcatatgtc 3424921 tctgtcattt tggttcagag attatgtgtt tatgagattc gtattttgga tgactaagaa 3424981 aaagtggatc aaaaaccgta tggccgtctc aaacatcggg tatttcctgc tgtttatgct 3425041 gatgggggtt tggcacgggc tcgcgccgca atatatcatt tacggcctct atcacgccgt 3425101 tctgatgacg tgttacaact ttttcgagaa gtggaataag aaatataaat ggctgccgtc 3425161 caaccgctgg acaaccattc tcgctattgt gatcacattc catttcgttt gcttcgggtt 3425221 ttatattttc tcaggaaaac catttcatca ccaccattaa aggagattag aaagctatgg 3425281 attttaaaca agaggtatta gacgttttag cagaggtttg ccaggatgac atcgtaaagg 3425341 aaaatcctga tattgaaatt tttgaagaag gtttgcttga ttcttttgga acagtagaat 3425401 tgctgcttgc gattgaaaac cgttttgata ttttagtgcc gatcactgaa tttgaccggg 3425461 acgtttggaa tacacctaac aacattgtaa atcagctgtc tgagttgaaa taatgaaaaa 3425521 gcgttttttc ggtccaatta ttttggcgtt tattctattc gcaggcgcca tcgcaattcc 3425581 atcttcatgg ctgacaggct tcatcaccga taagcgtgtg aaagagtcag caacagcctt 3425641 gaatccgagt atgtttcaag ggctatattt acaagatcag atgctcaaag atccgacata 3425701 tcttccgatt tacgggtctt ctgagctttc tcggctggac gagttccacc catctaatta 3425761 ttttcaggta aacaatgagg gattcacgcc ataccttgtc ggcaaaggcg gatcccagtc 3425821 attgattcat tctttaaact tcgctgccca catggatcag ctgaagggca aaaaaatcgt 3425881 attcatcgtg tctccgcaat ggtttattaa gcgcgggtct gatgaacagc atttcgcgcc 3425941 gaactattct gcgctgcaag ggcttgattt ggcatttaac gatcagatcg atcctgaaat 3426001 taaaaagaaa atgatgaaac gcatgcttcg ctttaaggct gtgcaaaacg atgccattct 3426061 ttctgagctg tacaaagcaa tggtaaacgg tcagacgtgg aaagtgaacg cgctgaagcc 3426121 ggcggcgaaa gtgtattaca gcatgctgga aaagaaagat ctgtattatt caacgacaga 3426181 atcatccggg ccaaagcgct atatctcgca gtcagtaaag gataagtcat ggtctgaatt 3426241 gaataaacta gcggatcaat cgggcaaacg ccactccggt tctaacgatt ttcacatcga 3426301 caaccctgtc tataaaaagc tgaagccgaa agtgcctaag ctgaaaggga aaaacaaagg 3426361 aagatcgtat gcggtgtcac cggaatatgg cgactttgaa atgatgctcg atatcctgaa 3426421 ggatgcgggc gcagagccta tgtttgtcac cattcctgtt aacgggaaat ggtacgatta 3426481 cacgggcttc ccgaaaaaag gacgcactga ctattacaaa aaggtaaata aacaaatcag 3426541 agcgaagggc ttccaggttg ctgatttctc agggcatgaa tatgacccgt atttcatgaa 3426601 agacaccatt cacatcggct ggaaaggctg ggtgtatgtc gataaagcaa ttgacgaatt 3426661 ttataaaacc ggaaaagtca cttcatcctg agcatctcat aggacgcggc tgcatatttc 3426721 ctgctaagat ttgtaatagt aaaggaatca cagccaactt aattaagagg tgttacatcc 3426781 aatgaagatg acaaataata cggttttaat cacagggggt tctgctggca tcgggcttga 3426841 actggccaag cgcctgctgg aacttggcaa tgaagttatc atttgcggac gcagcgaagc 3426901 acgtcttgca gaagcgaagc agcagctccc aaacatccat acaaagcaat gtgatgttgc 3426961 agaccgttcg cagcgggaag cattgtatga atgggcttta aaggaatatc cgaacttgaa 3427021 tgttctcgtc aacaacgccg gcattcaaaa ggaaattgac tttaaaaaag ggacagagga 3427081 gctttttgtg gacggtgatg aaattgaact taatttccaa gcgcctgtcc atttatccgc 3427141 ccttttcaca cctcatttga tgaagcagcc cgaggcggca atcgttcagg tcacatccgg 3427201 gcttgcgttt aacccgttag ctgtttatcc ggtgtactgc gcaacaaaag cggcacttca 3427261 ctcgttctcg cttacgctca gacaccagct ccgcgacacg agcgtggaag tgattgaaat 3427321 ggcaccgcct atggtggaca cgggcttaaa ccaaaaatca cgcgataaac aaggcctgac 3427381 gtaccggggc atttcatctg aagaatatgt tcaatatttc ttggacggct tgaaggaagg 3427441 caaacaggag attacaaatg aacgtgttga aggtcttcgg gatgccactc gcgccgatta 3427501 tgacaggtta ttcgagcaaa tgaacacgca ggagaattaa tttctcctgc ttttttcata 3427561 tgaatttctt acaaatttga gcaaacctat tgcgattatt tgttgaaggt atacaataga 3427621 atataattat tttcaaataa gtttgataat ataaacaatt taacagcagg gagattgacc 3427681 atgactaaac aaacaattcg cgttgaattg acatcaacaa aaaaaccgaa accagaccca 3427741 aatcagcttt cgttcggaag agtgtttaca gaccacatgt ttgtaatgga ctatgccgca 3427801 gataaaggtt ggtacgatcc aagaatcatt ccttatcaac ccttatcaat ggatccggct 3427861 gcaatggtct atcactacgg ccaaaccgtg tttgaagggt taaaggctta cgtgtcagag 3427921 gatgaccatg ttctgctttt cagaccggaa aaaaatatgg aacgcctgaa tcaatcaaac 3427981 gaccgcctct gcatcccgca aattgatgaa gaacaggttc ttgaaggctt aaagcagctt 3428041 gtcgcaattg ataaagactg gattccaaat gcggagggca cgtcccttta catccgtccg 3428101 ttcatcatcg caaccgagcc tttccttggt gttgcggcat ctcatacgta taagctcttg 3428161 atcattcttt ctccggtcgg ctcttattac aaagaaggca ttaagccggt caaaatcgct 3428221 gttgaaagtg aatttgtccg tgcggtaaaa ggcggaacag gaaatgccaa aaccgcagga 3428281 aactatgctt caagcttaaa agcgcagcag gtagccgaag agaaaggatt ttctcaagta 3428341 ctctggctgg acggcattga gaagaaatac atcgaagaag tcggaagcat gaacatcttc 3428401 ttcaaaatca acggtgaaat cgtaacaccg atgctgaacg ggagcatcct ggaaggcatt 3428461 acgcgcaatt cagtcatcgc cttgcttaag cattggggcc ttcaagtttc agaacgaaaa 3428521 attgcgatcg atgaggtcat ccaagcccat aaagacggca tcctggaaga agccttcgga 3428581 acaggtacag cagctgttat ttccccagtc ggcgagctga tctggcagga tgaaacactt 3428641 tcgatcaaca acggtgaaac aggagaaatc gcaaaaaaac tatatgacac gattacaggc 3428701 attcaaaaag gcgctgtcgc agacgaattc ggatggacga ccgaagtcgc agcgctgact 3428761 gaaagcaagt aagaaaaaag ccggcccatt acaggccggc tttttttacg cttcaatttt 3428821 gttgaaaaac tgcggcagat acgctttgtg cgcctctagc atttcgtcta aaatctgttt 3428881 ggccacagta tcggacggga caagcgggtt aatcgtcatg gcaaggagcg cagtttgata 3428941 gtcacctgta actgccgctt ctgccgcgac acgttcaaag gatttgattt gctggacaag 3429001 gccgcggaca gacaccggca agtcgccgac agcaattggc ttagggccgg ttttcgtcat 3429061 cacacagttc acttcaactg cggaatcgtc tggaatactc gctattgcac cattattgat 3429121 cgtgttcacc ggctgaatgt catgtttatc attataaatg gagctgatta agttacatgc 3429181 tgcatcactg tagtaagctc cgccccgttt ttccagctgc ggcggtttga tcgcaaggtt 3429241 tggatcttta taaagctcga acagctcttt ttcgaccttc tgtacgactt cagcgcgggt 3429301 gccctccgtt tgtgatgctt ccagttcgtg ctccagcatc tcttttgttt taaaatagta 3429361 acggtgatag ccgcaaggga tgacattgag cgcttttaag aaatccggtt cccattcggc 3429421 gcctgagata tttttcatcg tcatcgcgtt tttcgggtcg cccatcgcct cgatgacttg 3429481 ctccttcaca cttacgccgt ccaagaaaac atccagcccg aataccatat ggttcagtcc 3429541 ggcaaattgg acttctacgc ggtccacatc tacatcaagc gctttggcta cgcccatttt 3429601 gatgccgatt ggaacattgc aaagaccgac gactttcttc aggttggagt agcgaagcaa 3429661 ggcttctgtt accatgccgg cagggtttgt gaagttaaca agccaagcgt tcgggcaaag 3429721 ctcttctatg tcctttgcga tctcaaggat gaccggaatt gtgcgcaatc ctttaaacag 3429781 acctcccggg ccgtttgttt cctggcctat cactccgtat tttagcggaa tgcgctcatc 3429841 ctttgctctt gcctgcaaaa gtccgacgcg gaattgggtc gtgacaaagt ctgcgtcttt 3429901 cagcgccttt ctccggtcga gcgtaagatg aatgtcaatc gggacgccag ctttttcaac 3429961 catccgtttg gcgagtgtgc cgacaatatt cagcttttct tcgccctcgg ggatatcgac 3430021 aagccataat tcacggacag gcagctcatc ataccgttta atgaacccct ccactagctc 3430081 gggcgtatag cttgaacctc cgccaatcgt tacaatcttc aatccttttg tcatatgctt 3430141 gctccccttt gctcggtgat tttttcatat aactcaatga tctctgcagc catatccttc 3430201 actgtcattg cattcattaa atgatcctgt gcatgaacca tcagaagcgt catttccgtc 3430261 ttttctccgc ccgcttcatt ttggatcagc tctgtctgat aatgatgggc ttttgacaat 3430321 tcttcagcag cgtcttgaag ctttttccgc gcttcttctg cgtcaccgct tttcgcagcg 3430381 gcaatggcct ccattgcgga gctcctaccg tttcctccgt gaaggatgat ttgaaaaatg 3430441 atttgttcca tttcctcatt cacgcgattc acttcctttc tctacagagc cgcttctttg 3430501 tcatctgttg ctgcaggcgt ttggaccagc tccagatcgt tttcttcttt cagcttctgc 3430561 ttatcccaca ttctgaagaa tggatagtag acaacaaagg acacggcaat attaatggct 3430621 tgcatgaccg cgcctgagac ttttcctcct gtcgccaagt agcctgaaaa gatcggcggc 3430681 atggtccacg gcactgcgat acccgccggt ttggcgacaa ggccggtgct cattccgatg 3430741 tacgtgagtg tcactgtgac aagcggcgtg atgataaacg gaagtaagag cattgggttc 3430801 atgacgatcg gcattccgaa tataatcggt tcgttaatat tgaagatggc cgggccgacc 3430861 gcaagcttcc cgagctgctt catttgtttg cttcgggcgc gcaggaacat cgtgacaacc 3430921 agtgccaatg tggcgccgct tccgccaata ttgacccaga tatcgaaaaa ttgctgggtg 3430981 aaaatcttag gaagctcctc accggcttgg aatgcgatcc ggttggcatc cattgcgccg 3431041 taccaaatcg gtgccatgac gccgccaaca atgtttgcac cgtgaaggcc gcaggcccat 3431101 aaaagcattt tgacggcttc ggcgacaagg cttcctccaa ggcttcctcc cagaatggaa 3431161 agcggagtcc ccaataaaac gcttacaata ttatgaaggc tttcaaacgg tgtcgcttca 3431221 acaatcagcc gggctgccca aattaggaag atgacggcaa agccggggat taacgcgaca 3431281 aatgacttgc ttaccgccgg cgggacaccg tccggcattt tgaagactaa attgcgctgg 3431341 ataataaggc ggtaaatctc tgtggacacc attgcgataa tcatggcgac aaataagcct 3431401 ttgcttccca tgagcgaaag cggaatcccg ccgccaacca tgatttcttt cgtcgcgcca 3431461 tccggcataa acggcacttg ataaggtgtt gctaataaaa atgccgcaag ggaaatggct 3431521 ccggccgaca aggcatcaac accgtatttc tcggcgagcc ggtaggcaat gccgaacgcg 3431581 gcgacaagac ccataatttc aaaggtcgcg tcgactgggt aggccagttt ttcagaccag 3431641 gagctgccaa acgtttttgc cataaactca gcgtatcccg ggatcgggag gttgccaatg 3431701 atgaggaaaa aggaaccgat gataatcagg ggcatcgtga ggatgatacc atcacgcagc 3431761 gcctgcaaat gacgctgtcc cgcaattctt cccgctatag gcatgacctt ttcttctaag 3431821 atctgattga ctttattcac atagcccgcc cctctctatg acacatgtcc aagctgttca 3431881 gctgatttca gcacttccgc cccattgcac gttccataat ggacggtatt aatgacgtct 3431941 accggaaccc cctttgactc tcctaatttt ttgagctgcg gaagcatgta acggacttgc 3432001 ggaccgagaa gcaatacatc cgctttatcg atatgatttt gtacagaatc gcctgaaact 3432061 gcccaaatgg tatagtcttt tccctgttcc tgcgcacttt tttccatctt gctcaccagt 3432121 aagctagtag acatgcctgc tgcacaaacg agtaatatat tcatgtaaaa gaccccctag 3432181 agtttgatca attttgtaat gtcctgctgt tgctatcatc atattatgaa atcgctttca 3432241 taaacactca gggtttttcc gcaggcaacg gaaaaaaggt atatacaggc tgtcagctca 3432301 gcattttttg gtcaaacaca tccgaaagct cttgatatga acggcatttg atcagctggt 3432361 tcatcgccgc cgggtcatcc aaaatgctgc caagcagttt atacatgctt tgtaaatccg 3432421 ctttgttctc cttttcgaca caaagcagac agacaaattg aactcgctga ctctcccaat 3432481 cgatcggttt tttgagcgta caaacggccc aaaacgttgt tttcgtctgc ggaacaagcg 3432541 ggtgcgggat ggcaacaaga ttgccaaaac acgttggcga catgtcttct ctttcaaaaa 3432601 tggaatctat gatttcttca tcggcaaagc cgcattcgac cactttctgc cctaaaaatt 3432661 gaatcacttc ttcttttgag cgcagatcct cctgaaaaaa aacgagttct ttttttaggt 3432721 agcgattggc tttttccttt tcatcactca gaatagattc tatttttgta aagtcagttc 3432781 cgcctaagat ggtgttaacc ttcagtactg gtacagggag ctctttttta atcggaatgg 3432841 tgctgatgac aaaatcaatt gattcgtagg acatttgatc aagactataa tactcagccg 3432901 ttccaagaat atcgagccgc ttgccgaaat gggaacgcag tttttcgcgc agaagctggg 3432961 cgcttccggc tcccgatgcg catacaatga tacagcgttt cggcgggctt tctgtttttt 3433021 ttcgttcaat cgcggcgcca aagtggagag ccaaatatcc aatttcgttt tcatgaatct 3433081 caatacccgt ttgttccttt atcacgattc cggcaatgat cccggcttca aaagcgagtg 3433141 gataatgttc cttgatcgct gccagcatcg gatttcgaag attcatgccg tatcggttgc 3433201 ggctgatcgc cggcttcata tgcagtgcca agccgatttt cagctctttg tcatgcagga 3433261 tgccaagctt cagttcacga tcaacagctt tgatcatggc aagtgtcagc tgatcggttt 3433321 cctcttctat tgaaaatgtg tcctctccgc attgtgattg tgtcattcgt tttgtgccaa 3433381 ggagatgcat ggtgatgtag gccgtctcgt ctttcggaaa cgtaacggaa agctttgatt 3433441 ccagctcttt tacgatggct tctgcagcct ggtactcctt ttgatgcagg atatgatcca 3433501 tatctttcgg gaaaagagaa acatagtttt ccgttctgat ccgtttacag gcgatagcga 3433561 tatggataat gaggttattc agtcccatgt tggacagagg gatgcggtcg tttttcattt 3433621 ttttcaagat ggcggaacgg atgatctcaa tttcttcttt tggcaaaata tcagcctttt 3433681 catttaaaac atctatctcc gtttctcttt catcaacaat gtactccgcc atgcagtacc 3433741 tcatctgcac ctcgtccccg cgcagcttga agccgtaatt cggacgtgtt tccatgacga 3433801 tgcggtaagg cagcagacgt ttctttactt cctttaaatc cgtttggagt gtagattttg 3433861 agataaatag ttcttcagca agttcatcga gcttgagata atggtccgcc agcagcagac 3433921 gtttcataag ataggccatt ctctcctccg gcaataccgg caggcccttt ttttgctgaa 3433981 attcatcttg cagcagtgtt ctgaatactt gctcgtcatc aatgcggagc ttgtagccgg 3434041 agcctcttac agattgtaca aaggcaccgt ggccgcttag cacaccttga agttccttta 3434101 tatcattgcg gactgtccgc gtcgttacgt ttaattgcgc ggcaaaaaac gaacttgtca 3434161 ccggggcttc agccgccatc agcaagcgca gaatatcacg tagtcgccca tgaagcatga 3434221 gaaaaacctc ctaactagta gatgcaggga ttcagtgaat aggcagaaag gatgatgaag 3434281 ggatgcgaaa tgtatataaa ttctataatg gagagaatgg caagtcaatg aacatccgga 3434341 ggactagagg gaaaactgac ctataaaaaa acagccggga tcagccggct gttctagatg 3434401 cggacatatt cttttgttta gacgccttgc ggtccttcat gatttttcga acaatcgggt 3434461 aaatgaccgg cgcccatttg ataacggttt tgatcatctt tttcaaagct ccgattctcc 3434521 cttctttttt ctcaaccatt cccctgattg cctcttcctt aaacatgcta acgcgacacg 3434581 tacctgtttc ccgtcaccca gaaacgccat ggataatcgc gtgcctcccc gctgttgtca 3434641 atgccgatgc gcgggccggt tgaaattgct tccggtgtgt acccgctttc gatgtaaagc 3434701 ggctgttccg tgatccagcg tccgtagtca ttcatcgtga cgccaagcgc tttcgtcagc 3434761 tttcctggtc cgtttgtcca ttccctcgga ctcctgcccg gccttctctc ctccattaac 3434821 agctggcctt catgcggctc aatcgccctg attaatactg cttgcgggac atcctcttcc 3434881 gccgcaacga cattcagcaa tgtatgggtg tgcatcacgt atgtatatac ccgcccagct 3434941 tctgcaaaca tgatctcagt ccgcttcgtc cggcggttgt taaagctgtg ggccgctctg 3435001 tctccagccc ccatataggc ctctgtttcc acaatatagc ctgacgctgt gccttcgtct 3435061 gtttctttta caagaaggca gcccagaagc gatggggcaa gctcaagagc ggttttttga 3435121 taaaacgtga tgggcagcgg atttttttct ctcgtcacga atcgacctct ccttttaccg 3435181 atttttgtac attgtaccat tcccgaagca gatcaaaaaa aacggctgtt ttaaaatctt 3435241 tccattcagg gaatattgtt accgttcaaa aaaggagggc caaccattga aagatgatca 3435301 tcaaaacaag cagcaccaat caaatgccca agggagcgag gaagcgtttt ctcataagac 3435361 atccgggaaa aacgagtcag aggatacctt aacgaatagg caggggcatc ctgttactga 3435421 caaccagaat gtgagaaccg tcgggaatag agggcctaca acacttgaga actatgattt 3435481 tctcgaaaag atcagccact tcgaccggga acgcatccca gagcgggttg ttcatgccag 3435541 gggagcaggt gcacatggat attttgaagc gtacggaagc ttcggagacg aaccgatttc 3435601 aacatacaca agggccaagc tctttcagga aaaaggcaag aaaacaccgg catttgtccg 3435661 tttttcaact gtgaatcatg gaaaacactc gcctgaaaca ttgagagacc cgcgcggttt 3435721 tgctgtaaag ctatatacag aagacggaaa ctgggatttg gtcggaaaca acctgaaaat 3435781 cttttttatc cgcgacccgc tgaaatttcc ggatcttgta cacgcatttc agcctgatcc 3435841 agtgacaaac atccaggatg gtgaacgtat cttcgatttc atttctcaat ctcctgaagc 3435901 gacacacatg atcaccttct tgttttcgcc ttggggcatt ccggccaact accggcaaat 3435961 gcagggttca ggcgtacatg cctataaatg ggtgaatgag gagggcaagg ccgttctcgt 3436021 gaaataccat tttgaaccga agcagggcat ccgcaacctg acacagaagg aagcagaaga 3436081 gattcaaggg aaaaacttta accatgccac acaggatcta tatgacgcga ttgaaaatgg 3436141 cgattatcca gagtgggaag tatatgctca aatcatgagc gatgatgagc atcctgaact 3436201 ggactttgat cctcttgatc caacaaaact gtggtataaa gacgatttcc catggaaacc 3436261 gatcggcaaa ttggttctga acaaaaatcc ggaaaactac catgcggaag tggagcaagc 3436321 ttcatttgga acgggagtgc ttgtcgacgg gcttgatttt tcagacgaca aattgctcca 3436381 ggggcgtacg tttgcctact ctgatacgca gcgctaccgt gtaggcgcaa attacctgca 3436441 gcttccgatc aactcgccga aaaagcatgt cgccaccaac caggaaggcg ggcaaatgca 3436501 atatcgggtc gatagagcag aaggacaaaa cccgcacgtc aactacgagc catccattat 3436561 gggcgggctg aaggaagcga agcaagacgg aaaagaccat acgccgcatg tcgaaggtga 3436621 tgtaaagcgt gaagcgattg acagaacaaa caacttcgga caggctggag aaacgtaccg 3436681 gagatttact gaatttgagc ggaacgaatt gattacgaat ttggtgaata cgctttctac 3436741 gtgccgaaaa gaaattcagg atcaaatgat tgagaatttc acaaaagctg atcctgacta 3436801 cggaaaacgc gtagcagaag ggctaaaaaa ggtctccgaa aacaacagca acgggccgat 3436861 cggcacaact gaaacggaac aggctgcaaa gcaggctgaa caggagagtc atccgtctga 3436921 tccgtattaa caacagcgaa cagggctttt ttagaagccc tgttttttta tttttctatt 3436981 gaaacgcttt caataattgt gttgtacttg gaaggaaagg ggtggagaga tacgatggaa 3437041 ttacagcagg acttgattcc tcagaaaaaa acaatcggcg ctttagatca cgccgttttt 3437101 ttatgcatgg tattttgttt ctggttttca ggctatattt acgttcctgt attcagtctg 3437161 tatttggagg atctgcactt ttcatatggc gcaatcggca tcattctcgg cagctacggg 3437221 gtcacgcaaa tccttctgcg attcccgctc ggccttttgt cagacatcct gttttccttg 3437281 cgcaagcaat tgttaattgc cgggttcggc ttttccgtcc tcagcagcct gctttttctg 3437341 atgtttgatt ctttcttctt cgtgctggcc gcccggcttt tcgcgggaat cactgcttct 3437401 acgtgggtga tggcgaccat tttatacgca cattatttca acaatggcaa tgcatcaaaa 3437461 gcaatgggca tcatgcagtt ttttaccgtc atgcctcagt ttgccagcat tgtgttctgc 3437521 gggctcgccg cagcccattt agggaggcag gttccttttt ggatggcgct ggcagcttct 3437581 gccgcaggtc tggtgatctg ctgctttatt caggatccgt ctgctcctcc cgcaaaccgt 3437641 ggcaccattc gtgtcaatca gtacatcaaa gatacattgc ggctgccaaa gctgaagctt 3437701 ttcaccatcc tgtctatgac ggcccatgcc gtattattta tcacagtgtt tggttttacg 3437761 ccgctttaca tgaatcagct cggaatgggc gacgcggagc tgctttgggt gatgagcgcc 3437821 tttttcctcc cacacgcagc cgccacatta agctttgtgt ttctgcgctt tacaagccgt 3437881 atcgcttact ccgtgatgct cattagtttc gctgtcaccg gggtctgttt gctatatgtt 3437941 ccttttttag ctgcattgtt cacggtttgc atcacacacg cctgtattgg gctggcgctc 3438001 ggcttcgttt ttcctctgct gctaagccat gtcgtcgaaa tcagttctgc ccgtttaaaa 3438061 atgtcagtga tggggtttta ccaatcattt tatgcgctag gcatcttcct cgggcccctt 3438121 cttgccggaa aaatcgcaca gcttatcggg cttgcgggag ttttttatgg agccggttct 3438181 ctggcatttg ccgccttttt tgtgatgctc gcgcaaaaac gtaacatgat caattaatag 3438241 ctttcatacc gccggaagcg ccacacagaa aacacggcca gaagcatgat gcacagaatg 3438301 gagaaagtga gtgaccatcc gaaaaaatct gcccgctctc catgaagaag gatatgctcc 3438361 gcctgcttgc aaatctcagc cggaagccac ttcgcaccat ctggaaatag tgaaacagca 3438421 aaggaaacgg ctgctgtgag cccgatcccg caagccgcag ctgctccgac agaccggaat 3438481 atcgtacttc cggcaaggcc ggcggtcaca ataaatatca cccaaagagc gtaaaggcca 3438541 aggcttgcgg caaagcggct gaatgatgcg tcctcaaaca gcagccggac gtaatagtaa 3438601 gcaagcccgt atccagctgc aaacgacata atgccgatca cgctttggat gagccattta 3438661 ctcacgatat aatgggctgc cgtcacaggc cgcgacataa tcagcgctgt taccccttga 3438721 tttctttcat tggctacact gcccatcacg ctaaagatga ccagagccat gccaagcgtg 3438781 ttgaattgag aaagcgtgct gaccatcact tcagacccgg agggcatcgt aaaactgatt 3438841 ttcatgccgt caggaaggtt ccctccatgt gcgatgattt ccggcatata ataaatggtc 3438901 agcggctgtg tcagcccgac gatcatcatc gcaatcggca gccaaatcag cttgccgctt 3438961 ttccatcctt ccagccactc cttctgcaat agcgccatca tcaccttcat gcgtgcacca 3439021 cctttagata gacgtcttct agagactccg ttttctgttc aaagcgggtg acggtcaatc 3439081 cctttcggat acagtcactt aataatgacc ggccagcgtg tatatcaggc agctcgaaaa 3439141 ccgcttggga cggattctta tagacaatag ctgagacgta aggcttctct tcaagccaac 3439201 cttccagctt ctctttcact gaaagggtaa aaacgttcgt ttgctgctgt tgtttcagct 3439261 cctgtaactc gcctttccat gaaatctcac cgtttttcat aatcaccact tgatcacaca 3439321 cctgttctgc atcgtgcaaa acatgtgtag aaaacagaac ggccatatgc tttttcagct 3439381 cccgcatcat gtccagcacc tcgaaccgtc ctgtcggatc aagcgcagac accggttcat 3439441 ccaatatcaa aaacttcggt ttatggagca gtgcctgtgc cagaccgagt ctttgtttca 3439501 tgcctcctga atagcccccg atccttttgt gcgccgcttc gtgcaaaccg acaaattcca 3439561 gcatctcgcc gattttctct tggcattttc tcttcgaaag gccggacagt ctccccgcaa 3439621 atgtcaaaaa ttcatttgcg gtcatccacg aataaaaagc aggatactgc gggaggtacc 3439681 caatcaaacg ccgatccagc tttttctctc ctaacagctt tatggttcca gaggttggcg 3439741 aaagcagtcc ggccagcatt tgcagagtcg tggttttgcc ggctccatta ggtcctaata 3439801 gtgcgacaca ctcattttca ttcacgtgaa aactgacatt ctttacagct tcatggtgcc 3439861 tgtacgattt gcataatgat tcaatagaca gcatatcggc ttacctttgc tttctgccga 3439921 cggtgaaaaa taaaatcggc ccgataatat tgatacatac gatgattgca gcccacatcc 3439981 actttggccc gttcgtccgc tcttctttta tacagctgat aagggcaaac accgccaaag 3440041 ccagctgtaa tacaatcagc ggcaaaatca tttcccaaga aatattcatt gcttgatccc 3440101 ccttttcttc cgatccggcc taatgacaaa aaagtaataa caaatcagag gcatcggtgc 3440161 ttgaatcaat ccgacaatcc cccaaaccca tgccatgtga ttacgttttt tcgcatcaat 3440221 aaataaaaag attccctgcg ccaatacgat gagacaagcc gcaaccgtta tgataatttc 3440281 tgtttgtgtc atccgcgttt cacctcgcat tcgccgagat gccttttttt ctcagccgca 3440341 atcaaaatcg gcagcaccgc aagcacacaa acctgaagca caataaacac agcaggagct 3440401 tgagtgaaag ctaagattgc agcactcaca accatcagcg cgcagaatac aaataaaatg 3440461 atctcttgaa gaagtttttt tctgtattca gctttcattt gtgacagctg gtgaagcagt 3440521 tctttttgat tcggtataga gggattggct gtttgatcaa tttttttcca ttctgacttt 3440581 aaatgatcag aaagcttttc tttattcatc atcccactcc tttctgattt gctggagccc 3440641 tttatgaact ctggacttta cagtgccttc tttgatttga agcatcaccc cgatttcagc 3440701 gtaggtatag ccgtagtaat gccttaataa aaccggtgtg cgcagtttag ggtccagctt 3440761 tgaaaacaga tcgagcgttt cgctccactc tgcccctttc gccgacacgt cccacttgat 3440821 cttgcggatt gtttcctccg taactgtctg attccgtttc cattctctct ttctcttttt 3440881 ctggtgatcg agatagagcc gcgatgcaat ggagatcagc catgtggaga attttgaacg 3440941 gccctgaaag cttcttaaat ggatgtaccc tttcagaaag gtttcctgaa caagttcctc 3441001 gctgagatcg gggtgaaggg aaagctttaa caagtattta tataagaaag aatagtgata 3441061 gtggaaaagg gctgtaaacg cctcgtcgtt tccctctttc gcctgctgga tcagccgctg 3441121 ttcttcttgt gtatccaatg accgtgatcc cccctttttt gtttttctgc cttatgagac 3441181 gacaccggat tcaaaagcgt tcatcttttt tacaattctt ttcagccatt gacagatcag 3441241 gcttcccggc cgtttggctg catatcctta tttgtaaacc cccttatagt ctgttaagct 3441301 atgactttat gtcgatttca aaaaaacatc caatatggag gacgatgcat tgaaagtaga 3441361 aaggcgaacg attgaatata ttccgaatga agaaagacat ggtaaagcga aagatttatt 3441421 tcccgtatgg ttcggggcta atatgcatat caccacgtta gtgaccggca cgattcccgt 3441481 tgcaatggga cttaatctgt tttggagtgt tgccgctatt atttgcggaa ccttaatcgg 3441541 tgccatattt atggcttctc attccgcgca aggccctcag ctaggcatcc cgcaaatgat 3441601 tcaaagccgt gcccaattcg gcgtaatcgg agcgattctt cccctcttct tagtcatgtt 3441661 tatctacctt ggtttcttcg caagcagcac gattctggcg gccggaacct taagcagctt 3441721 tgttcccatc ccgggatcat ggagcattat aggcttaagt gccgtatgtt ttttactcac 3441781 cattttcggc catgatttga ttcacaaaat gcaaaaaatc ctttcttgga cctcttttgc 3441841 tgtatttttt gctgcaacga ttctcatttt tcaattgccg attccggcag gcagctggat 3441901 acccggagcg attgatctgc caattttcct agtggcagtc agcgcagttg cgacgtggca 3441961 gcttgcctac gcgccgtatg ttgccgatta ttcaagatat ctgccagtta aaacaccggc 3442021 ttcaaaaaca ttttggtaca gctatgcagg tacatctgtc agctccatct ggatgatgct 3442081 gctcggcgca ttgctgacaa cctcacttcc tgactttacg gcaaactcag gcagccagat 3442141 tgtccaattg ttcggtccct tctcgtttat tatgctgatc attgtgctat ttgggcaaat 3442201 ggcaatcaat gtttttaacc tgtatggggc tttcatgtcc acgacaacaa cgctggagcc 3442261 gtttctgaaa ttaaaagtca cgcccaaagt cagaatcatc atgatcctgg gtgtcacgct 3442321 tgtcggcaca gtcttaagcc tactgggaca gagcaatttt atggaactgt ttttgaattt 3442381 tatctttttc atcagttatt tcttaattcc gtggacggca atcaatttag tcgattacta 3442441 cttcgtccgc cacggaaagt atcaagtcaa agccatgttc gacgtaaacg ggccttatgg 3442501 aaaggtcaat tggatcacca caattgcgtt cgttctgtct atcttgctgg aaattccgtt 3442561 tatcaacaca agcttttaca tcggaccgct tgccaaaatg tttggcggcg gagacatcgc 3442621 atggattatc ggcttggccg tgccttctgt gctttactat gtattaatga aaccgcgtct 3442681 gaaaaaacgg gcggggtatc aagaaaagct gtcttctctc tgaagacagc ttttttatca 3442741 ttcaaatcgt ttccacacgc ggggcaggat gtcagatagc tcatgagcga gcaacgtatg 3442801 agcggagtgc tcgtccgtcc agagctcggc gcacgcacca tgcaaataga ccgcgtttaa 3442861 tacggcgtgc tttggatctt catggcagca gagcatcccc aatatcatgc ccgtcagcgt 3442921 gtcaccggtt ccgcccttgg cgagcgcccc gtttccggtt ggattgagcc agcagtctcc 3442981 atcaggaaac gcgatgacgg tttggtttcc ttttaacaca atgacagtct gcagctgagc 3443041 cgcccattcc tttgcatatt ccgctctttt tttctgcaat tcgttcacgg gcacccctgt 3443101 cattcggaaa aactcgcccg ggtgcggcgt gaggatgacg gggccctccc gtttcggata 3443161 tgtgcgcttc gccagcgctc cggcatccaa aataacagga caatcagccg taagcacatg 3443221 atcgactgcc tgctgtacgc tttccgtttg cggaaggccc ggtccgatgg caatggcccg 3443281 gtacgtctct tcaagctgag catccgccgc ctttttccag ccgtcacgcc aataggtcgc 3443341 ctcgggcaaa acaggaacaa ttagcgggat tacgttttct gatgtaccga tgacaagctt 3443401 gccgagaccg ctccgcatgg ccccaagccc tgcaagcagc gctgctcccg gcatgtcgtc 3443461 acttccagcc agcagcaaag ccgtaccgta cgtgccttta tggctctccg catctctttc 3443521 aggaagcgtg gcccttacat gctcttccgt ccaaaatgga acattcatct ctatccctcc 3443581 tctgctttct tttcctattt ttcctgtccc ttttcttttt caaacaaaaa agacagcctt 3443641 ttagggctgt cttttatttt acaggaacat caaggtgata caggcggcga tatcgttcgt 3443701 ttgccgccag cagctcctca tgggttcctt ccatttctgt tttgccgttt tcgagaaata 3443761 cgattttatc ggctgcttcc actcccgcga gatggtgtgt aatccataaa atcgtttttc 3443821 ctttcagcac ctcaaacacc gtttccatca attcacgttc ggtaatagga tcgaggccga 3443881 ctgttggctc atcgaggatg atgatcggtg tatcctgcag caaaatcctc gcaagtgcga 3443941 tccgctggcg ctctccaccg gaaaaacgga tgccggtttc ttgtacagag gtatgatatc 3444001 cgtcaggcaa tgactcaatg tagtcatgca gcttgacctg ctttgcggcg cggcgcacat 3444061 cctcgtcgct tgcttctccg tttccgagcc tgatgttgtt caaaatgctt gtatcaaaca 3444121 ggtgcggttt ttgatttaac acggccaccg catccgcaat ctgatccttt aacagcgctg 3444181 tctccactcc gtttaacgtc acagaaccgg agtccggttt caaggcgcct tcgattaatg 3444241 caagcgatgt tgatttccca gagccgcttc ggccgagcag cgccattttt tctccttggc 3444301 gcagcgtaaa ggaaaagttg tgcagcactt ggctgctgtt gtcataagaa aacgtcacat 3444361 cacgaaaggc caaggtgaca tcttgaagat cgagaatttg atcccctgat tcagtttgtg 3444421 acgcctccgg ctgaggagcc acattgttca tgcgtctgat agaatcctga tagcccggca 3444481 cttcgcctaa ggcatccgaa agcggcaaaa aggcttccgt caacggaaac accactagca 3444541 caaaagcggc aatcatcgtt ttagcgagct cgccgtccgc ttgctgtccc gctgtccaaa 3444601 acagcatcag caaaataagg ccagcgacaa ggcattgcgc agcaaagtcc cgccatcttg 3444661 taaagcgttg ttttttccgt tcaagctcaa accaatcacg ttcctctttt tcataagcat 3444721 caataaaagc atgccggcgt ccgctgaaca tccagtcgct gacacccatc acagcatctg 3444781 tcagacggct gtacagcaca ttccgtccgc ttttcagctt cgcattcttc gctctcgtca 3444841 cgagcaaaga cacaaccgga aacaatacaa caagaacaaa caaatacagc gcaagcaata 3444901 tggcaaacgg ccaagagaag aagccgagcg ctatcactga cacagcatac aggagcaagg 3444961 ctgagatcgc aggaaaaatc gtttttaaga aagcatcctg caaatgctca atatcctcag 3445021 acaaaatgcc gagcatatcc cccgtgcgaa aacgggaacg cagcatcaaa gcacccggct 3445081 caagcatatt gtaaaggcgg acgcgcatgt cagatacgat tttcaaaatg atgtgatggc 3445141 cgacgagccg ttccacatat cgcgacacag agcgcgcaat cccaaaggtg cgcacagcga 3445201 caatcggcac ataaatgagc agaatgtttt ccggccttgt cgccgcttta gaaatcaaaa 3445261 aacctgaggt gaacatgaga aaagcagcag aaaaaatcgt caccgcaccc aaaaagataa 3445321 ccagaacgaa caggcgggca ttttgcttga tatacggcaa aatccattct tctttcttca 3445381 tgctctttcc cccagttgtg ccttcacgag tttggtatac acaccgtttt tctccagcag 3445441 ttcattgtga gtcccaattt ccgcaaccct gcccccgtca agcacgataa tttcgtccat 3445501 atcgagcatc cagtgaaggc ggtgagtcgc gagaaagacg agcttatcct caaataaatc 3445561 cagcatcgtt tcttttattt catattctgt ttcgatatca agatgggcgg tcggctcatc 3445621 cagcagcagg atcggacggt ttcccaaaaa ggcgcgggcc agcgcgacac gctgtgcctg 3445681 gccgccgctg agcgcccggc cgccttcccc gatccgcccc tctaatccgt caggaaggtt 3445741 gttcaccagc tccgtcagtc ccgctgaggc agcagcacgt gttgtatcct ctgccgaagc 3445801 gcttggatgg tagaagcgaa tgttgttgcc aagcgtatca tcaaaaatgt acggatgctg 3445861 gggaatgtaa agaaggttct tctgccagct gccgtcctgc aaatgggacc ggcttgtacc 3445921 attaacctca atcatcccgc catccggctc taaaaatccg ccgagaatat caattaatgt 3445981 tgattttccg gcgccgcttg caccgataat gccgattttt ttcttgcctt tgaatgagag 3446041 atgaatatca gacaccgaac ggccgactga cacgcctgac agcttcagct catcctgatc 3446101 ggaccaagct tcgagctgaa gcggcgtctc ttctttaaaa ccaggctgcg acaaaatctc 3446161 ttgaatggtt tttcctgctt cctggccgtt cagcgttgca tgataatcat tccccacttc 3446221 ccgcaccggc aaaaaatact caggcgccag aataagcgcc gttaaagcag ggccaagcaa 3446281 aatatcgccg tcaatgaggc gcaggcccag aaatactgcg actgtcgcca ccgacagcat 3446341 cgtgaaaaaa tcgagggcga atgatgacaa aaacgccacc cggagtgtgc tcatcgttgc 3446401 cttgcgatac cgctcactca catagaaaat atttttgctg tgtgacttgc tcaaacctag 3446461 gaaacgcaat gtctccagcc cgcgaagaga atcaacaaaa tgattggaaa gtctctgata 3446521 ggatttccac tgacgatccg cttttctctg cgcgacaagg ccgaggagaa tcataaagat 3446581 gatcagaatc ggcatagcag cgactaaaat gatggctgat gtccgatcct gaaaaaacac 3446641 ataaatgaca actgccgcag gcacaatcgc catgctgacc attttcggca gaaacagctc 3446701 caggtagcgg cggaactggc tgatgccttc catcgccagc gtcaccattt gccccgtccc 3446761 ctctttcttt gcaaagcggg ggcctaatcg gaacagctga tcaagaaaac ttttcctcaa 3446821 atctgctcct gtccgggcgg cgtattgata gacgattttc tgtcgcgcca ccgtcatccc 3446881 gtgccgggcg ataaaagcga tgaggaaaaa gccgatcacc ggtaaaaggg aggtaatgcc 3446941 cttcccgttg aacagtccgg ttacggcctc actcagccac tctgcctgca taataatggc 3447001 ggctgtctga atcaacgtta aacaagtaat caaggtgaga atccgcttca ttcctttata 3447061 tcgaaacagg tcttttccca ttaataagtc ataggctcct tatggctgac gcgcttccgg 3447121 aagacataat agctccagat ctggctgccg atgacgaacg gcaatagcgt taatgctgca 3447181 attgacatga ctttaagcga ataatctcca gaagaagcgt tagctactgt taaatcgtat 3447241 gcgctatgaa gcgagctgac cattacacga gggaataggg aaataaagat cattcccacg 3447301 gtcagcgcca gaccagcgcc tgtcatccca aatgtccagc cgtctttttt cttacgaata 3447361 aatacagccg cgagcataaa gcagatgaca atcaaaacag cgagcggaat ggtaatctcg 3447421 ccgcggcgtg taaacatgtc tgtctgatac gcagaaaggg ccgcgaaggc aagaaccgct 3447481 acaaaaacaa cacccattat cttttgcgcc attttccggg cgcggttttg caaatcacca 3447541 atcgtacgca gcgtgataaa cattaatcca tgctggaagc aaagaagcgt taccgtcaca 3447601 ccgccaagta tagaatatac attgatataa tcagatacat gtgcgtgaat gttcatgtcg 3447661 gcatcaatcg gcatcccgcg gaataatgtc gtgaacagca caccaagcac aaacggagga 3447721 attagactgc cgaaaaaaac gacccagtcc caaaccttta cccattttaa atgatccacc 3447781 ttgccgcgga actcaaacgc gaccccgcgg cccattaacg caagcagcac tatgacaaac 3447841 ggaatgtaat aaccgctcag catcgttgca taccagtttg ggaatgccgc gaaaatggcg 3447901 cctgcgccag tcaaaagcca cacttcattc gcgtcccaga acggcccgat cgtgttgatc 3447961 agcactctgc gttctaattc attatggcca agaaaacggg tcgccatgcc gaccccgaaa 3448021 tcaaagcctt ccaaaaagaa gaatcctaca aacaatacag caacgagtat aaaccaaaga 3448081 tcatgaagag atgccatggt atacctcctg actaaatgga tctgttgata caggcacatc 3448141 atgatgatta tcatgctccg cacctttttt aatctcacgg ataaacaaga agacaagcag 3448201 tgcaccaaga atcatgtaca tcacaccgaa tgcgatgatt gagaataaca aggaacccgc 3448261 tgttacgtta ggcgacacag attgagcggt tgtcattaac cccataaccg tccaaggctg 3448321 acgtccgatt tctgtcataa tccagcccgc ggagtttgca agaaacggga aggaaatcaa 3448381 cgcgatcatg atgcgcaaat accatttgct gttttcaagc tttttacggc ggtttaacca 3448441 aaggccgcct aacgcagcaa gaatcatgac aacacctgct cctaccatga tgcggaagct 3448501 ccagaatgtc gttttcactg gcggaatgta gtcgcctttt ccgtatattt tttcgtactc 3448561 agcctgaagg gttttcatcc ctttgacact tccgctgaat ttctgataag ccaagtagct 3448621 caaggcataa ggaactttga tttcatttga gcttttttca ttttttgtat cgatcgtcgc 3448681 aaaagcggtc caagcagcag ggtcaccgct gtcttcccat aggccttcac tggcagccat 3448741 tttcatcggc tgtgattcca tcaagtgctc agcctgcatg tgtccgctaa ggccgacgcc 3448801 aagaccggca caaagaccga cgatcattgc gagtttaaaa gattgcttaa agaacggcac 3448861 ttcttttttc ttcagcagtt taaaagcact cactccggca ataaagaaag ctccagtggc 3448921 aagcgcaccg aaaataacgt gcgggaattc aacccaaagc tgagggtttg taatcaacgc 3448981 gccaaaatca ttcatttccg cgcggccgtt tttgatcgta aagccgaccg gctcctgcat 3449041 aaaggagttt gctgttaaaa tccagaaaga tgacatgatc gttccgaatg atacgagcca 3449101 tatgcagagc gcgtgaattt tcttcggcag gcggtcccag ccaaaaatcc ataatccgat 3449161 aaaaatagat tccatgaaaa acgccaataa tgcttcaatc gcaagcggag cgccaaatac 3449221 atctccgaca aaacgggagt aatctgacca gttcagtcca aactggaatt cttgcaaaat 3449281 ccccgttaca acaccgactg cgaaatttat taagaataag tgtccccaaa actttgccat 3449341 tttgagatac agctcatttt tctttacaag ataaagagtc tccatcaacg caaccataaa 3449401 cacaagcccg atagacatcg gcacaaacaa gaagtgaaac aacgttgttg atgcaaattg 3449461 tatgcgggct aataccaatt cactcatgct ttctcctcca tttccggtta aaactgttaa 3449521 tttgctcact acttcacaaa tagaaccgag actttgatca gtaattcaca aaatagacga 3449581 aaaaaatatt gctcaatatt tcacaaatgt gtcaaaaagt catccaatat gatgcaagat 3449641 tgccagactg accaaatgac acaatctctg actggttcat attaagtact ttacaacgat 3449701 tcatttcaaa aataaagcct aaaataccta aaaagtcccg cactatgtga cggatttttg 3449761 tctattttgt tgcttattta tgtcggctgc taggataaat gaccctttat tatcgtacat 3449821 caacacatcg ttccttgcga acaaaatgct tgcccccgcc ccagcactcg agtctcagca 3449881 ttccgtctta aaccgatttt agtcagaatg cctcttttca tttgaaccgg taagaggaga 3449941 aaagttgaat agtaaatttt taatatatta ataatttcaa ttttttagta tacttaacat 3450001 agtgaacaat ttcactgcat caagaatagg ggaggttttt caatgggaga gcttcaaaca 3450061 cacatgcaat tgcaaacgga tacaattcac gaaggggttc gaaaagagaa ttggtttgcg 3450121 aaagccatga atataaaagt aggcatcata ccgcttcctg tgtatgcctt gctgtttata 3450181 ttaatcactg tttttgttat gcatcacgat gtaaaaagtg acattttgac atccattgcc 3450241 gtcatggcgt ttttcgggtt tacctttgcc caaatcggca aatcgatacc gattgttcgt 3450301 tctatcggcg gcccggccat cctagctact tttattccgt ccgctgtcgt gtactatcac 3450361 ctgctgccta atgatatcgt caaatccacc acagaattta cagaaaactc aaactttcta 3450421 tatttgttta tcgccggtat tgtcgtcgga agcattctcg gcatgaaaag agaaacactc 3450481 gtaaaagcat tcatgaaaat ctttattccg cttattgtcg gttctgtcac agccgctatt 3450541 gtcggactgg ctgtcgggac attgctcgga ctcggatttc agcataccct gctgtacatt 3450601 gtcattccga tcatggctgg aggagtcgga gaaggcgcta tcccgctgtc catcggatat 3450661 tctgacatca tgcccatttc tcaaggggaa gcgtttgcac ttgttctgcc atcgattatg 3450721 ctgggcagct tgtgcgcgat tattctagcg ggattgctga accgaatcgg aaagaaaaaa 3450781 ccggaatgga caggcaacgg caaagtggac cgctccgaag aagagtcccc tgcgctggag 3450841 gaatctcaaa gcggacagca aatgttcaac ctttctttat ttgcgtcagg cggtatcctt 3450901 gctgtttctt tatacttagt cggcatgctc gctcacgatt ttttcggttt tccggcaccc 3450961 gttgccatgc tgttactggc tgttctaatc aagctgttca gattggtgcc tgcctcaatt 3451021 gaaaatggcg cgtttggagt gtcccgcttc ttttcaacag ctgtgaccta cccgcttctc 3451081 tttgcgattg gggtatccat gacgccgtgg gacaagcttg tcgccgcttt taacctcagc 3451141 aatattatca cgattctgtc tgtcgttgtg accatgatgg ccgttggctt cttcactgga 3451201 aaatggctga acatgtatcc gattgaaacc gccattatta atgcatgcca ttctgggcaa 3451261 ggcggcacgg gtgacgttgc cattttaagc gccgctgaaa ggcttgagct aatgcctttc 3451321 gcccaggtgt ctacccgcat cgggggcgcg attacagtat ccttaacctt attgctgctg 3451381 caccagtttt attgatcccc gcaagcaagt tcttcgtcaa acgaaagagc ttgctttttt 3451441 gcatgtccat gtttttgcaa gttcccatcc catgctatag taatagttgg aaatactaga 3451501 tagaaaggaa tctggcatgc ctatgggaac tcatctattt ctctttatgc ttctcgggct 3451561 gggattttat ttgatatcag ccctagctgc aaaactcatt ccggccatag acttctggat 3451621 tgatattgtt ctatgggtcg gcgctgcggc ttacatcttc tctcatctct cattcatgga 3451681 cggcattgtc tcactcgcga caatgttcta ctgctattgg accgcaatgg atctcattgt 3451741 ttcagagcgt gtggaaaaac cttcgggaga ctggcaggaa atcgagcttg ccaaaaacaa 3451801 aacacgcctc ctgtcagaca ttacgctgac cgccattgtg tttgcagggg ctgtcatttt 3451861 tttcatctat ggacctgaca caagccctct caaatatgtg atccttctcg gaatgatctc 3451921 cggcggaggg gcacttgtga agcgaatact gaatgttttt agcgtaaagg ttttttattc 3451981 agcagcctta gaaaaattgc atatcagctc acactatgaa acccgtacat acccgctttc 3452041 cgatttgaag aacattcagc ttgaatcaac agcagatctc ttaaagctcc atccgcttct 3452101 gacgatgtat tcatcccgtt tagatttgac aacaagcttt cagcaagtca ttaaactgtc 3452161 tcttcccggc gaaacactgt ttctgacggt gaaggaaccg caaaaatgga aaacaattct 3452221 tcaggaatac acagatgcag aaaacaatgt ggacaatgtg atttctgttt tgccgtttta 3452281 tcatcgaaaa aatgtgaagc ggctgctcgg taagctttat tttgccgcca gcgtaaaagg 3452341 ggtatccgct tacgccttat tggtgctcgc gttatacgca ttacacgcct ctccatgggt 3452401 catggctgtt gccgtaatcc tatattgggt attcaacatg tatatgtcag accgtgtgtt 3452461 gcgggcggcg atggacgcca agtcttgtca tcatccgcat gtacaggccg cggccgataa 3452521 gattttcaga tcggccggca tttcccatgt ccgcatatac gaaacggaga gtgatgatta 3452581 caacggaatg gcagtaggca tgaatgtcgg gaggtcaatg gtcatcctga caagcgccac 3452641 actaacactt ccacagcgtg tcattgaagg cattctggcc catgaggcga ttcatatcaa 3452701 aaaacgtgac gttctgtcat cacagctttt gcgttttcta tatcttggag ctgtcgtggg 3452761 gattttcctc ttgtttgagc agcatatcac ccatcccgag gcccacaaaa ttgcgctttg 3452821 ggctttcatt atggcaatca ttatcctatt ccagctctat caatcctttt gttcacaatg 3452881 gatggaggtg cgtgctgaca accttggcgc atcattgctg gacggcggtt acaaacaaat 3452941 ggctgaagcc ttgagaatct tggcggttcg gcaagatgag gatatacaga aacaaagtgc 3453001 ctatagctct gaagcaggtg aagacgagct tcaaattgat tctctcaccc gtgataaaag 3453061 ctggtttttc agattgattg attttcagtt cgctcctcat cctcctatgt attggcgtgt 3453121 cggcacttta ttgtcaaaca aaggacatgg ggtgctaaag cgctggctca gagaccgact 3453181 gaaagaatcg atcactttga aatgaaaccg gtcagcgttt catccgtata acagatatgg 3453241 tgaaaaaagg gagtgacgcg aagtgattgt gatcatctta ttgtttatat ctattattgt 3453301 ttttctttca gtcattcagc cgcagccctc gaaaaacaaa agccgccagc aggcggacag 3453361 cgggtatttc ggttattcag atcatagctc acaccatgat ggatgcagca gtgacggagg 3453421 tttcagcgat tccggctgtg gcggcggagg gggcggcgat taaacgccgc ctttttttat 3453481 ttcattgatt cgatgtacgc accaaaagcc gagcctgaca tgcctgggga cacgcgcaca 3453541 cgatggaggg catacattcc ctggtctctc gaagccgcgc ccggttctgt cgtcacgccc 3453601 atttgatagc ctgttttttc agcggccttc agcgtctcct cattgtagcg ccctaccgga 3453661 tagctgatga tggtggtttg ctgatgaaac atgttgtcga acagcttttt cgaatcagcc 3453721 atctcacttt gctgctgttg aggcgttaat ccgttcagct caaggtggtc aatcgtatgg 3453781 ctttcaatcg atatgccgtg ctgtgccatt tccttcattt gttcctctgt cagatggtgc 3453841 ttatgtccga tcgatttgcc gatcataaaa atcgttgcct tcatcccgta ctttttcagc 3453901 accggatacg catcttgata attgtcggtg tacccgtcat caaatgtgat cagcacgcac 3453961 ttctcactcg gttttttatc ctgcgtcagc atgagagatg cctctttcgg cgttaatgtc 3454021 tgatagccgt tatcatgaag ccacttcata tgcgcctcga attctttctt tggcacacgg 3454081 aggctgtttc ctgaagaaat gctgtggtac atcaaaatcg gcagctttgc cggtttctct 3454141 gttttgatcc atgcggatgt atcgtcttct tttttctgaa cttgtactgc ctttttttcc 3454201 ggtttctttt gttccgcttt tggcatcggc tgctctgcat tcgcctcttg atcagcacaa 3454261 gccgcaagag ccaaacagct gcccaaaaga aagatgctta aaaacaatcg tttcatcgtt 3454321 ctcctgcttt ctgtctattt cttcctcctt tttcatcggt ttgattctga gattttcaat 3454381 agcaaaaaac cggacatgtc tccatgtccg gtttttttga tcttatcgga ttctcacttc 3454441 tgtctcactg tcaaagaaat ggcctttatt catatcaaat gcaaccgtca gctcatcgcc 3454501 cgattgaata tcgaggcggg cgtcgatccg cgcaataaag tcttggttgt ctatctgcga 3454561 ataaatcata atttcagaac cgagcagctc tgcaacatta attttcgcct taatcgaaga 3454621 gttcttatat gattccacga caatcaattc atcatgtata tcctcaggac ggatgccgaa 3454681 gatgacctct ttgccgatgt agcctttttc acgcagcact ttcatttttc cttccgggac 3454741 ggttaatgcc gcagaaccga ttttgattaa gccatccgtg agctttcctt tgaaaaaatt 3454801 catcgccggt gatccgataa acccgccgac aaagacgttt tcagggaatt catatacatc 3454861 cttcggcgtc ccgatctgct gaattttccc atctttcatg actacaatcc gtgtcgccat 3454921 tgtcagcgct tctgtctggt catgcgtcac ataaatcgtt gtagtctgca atctctggtg 3454981 gagcttaatg atttccgccc gcatttgcac cctcagcttc gcgtccaggt ttgacaaagg 3455041 ctcatccatc aggaacacct ttgcatcccg cacgattgcc cggcccagcg caacccgctg 3455101 tctctgtccg cctgacagcg ctttcggttt acggtgcaaa tattcctcaa gcccgagaat 3455161 tttagcggct tcttcgactc tttttttgat ttcaggcttc ggcattttcc gaagcttgag 3455221 cccgaacgcg atattatcgt agaccgtcat atgcggataa agcgcgtagt tctgaaatac 3455281 catcgcgata tccctgtcct ttggcgctac atcattgacc cgttttcctt caatataaaa 3455341 atcacctttc gaaatttctt caagtcctgc gaccattcgc agcgtcgttg atttcccgca 3455401 gccggacggg ccgacgaata cgataaattc cttatcggca atatgaaggt taaagtcatc 3455461 aaccgccggt tccttctgat cataaaattt ataaatgtgc tccatccgca attcagccat 3455521 ctaacatccc cctttgttat tgtaaacgct ttcttatatt gagtgtaaca gcaattccct 3455581 ctcgctaaaa tgggcagcgt tcataaaatc acccagccat ttttcgtgca tatttccaat 3455641 ttattctgaa ctttcatttt gcaggcagat aaaataggca agaagcgcgc ctttgtacga 3455701 tttgatatct atccctgacc gctcaataaa tttatcaatc cgatattgca ggctgttgcg 3455761 atgcagatgc agctttttcg ctgttaatgt gacgtttgag ttgttttcaa taaacagctt 3455821 aatggtcttc cttagctcag attcacttcc aaataaaagc tcagcttctt cagagagcag 3455881 tgtttccagt ttttcttttt ctgtttctaa taatagaaaa ggaaagatca tctcaaaggt 3455941 cacactctgc acctgaggca gccgtttttc agcaaacagg aaatacgcct gttcacgagc 3456001 gtaatgtttt cgcagacact catccggctc gtaaaatctt ccggcgtaaa aacggacact 3456061 gaagtagaaa tcactttcaa gaaccttagc gagcgattcc agttcgtcct tctccgccgc 3456121 cgcttcactt tcctgctcga caatcacacc tctgtcctca tggatccaca caatcacaaa 3456181 agacaccggc caaaaatggc gaaccgcttc cgtaaaggac gtcctttcta ttttgccgaa 3456241 taaatgaaag tgaacaaatc tcgtccgttt ctttatatac gccggcaatt cccctctgga 3456301 aaaaaggaac gaaaaccact tgttttcctc aggtgatttc atagacagtt gattgccctc 3456361 atccgcaggc gtcaaaaatg actgcagcac caatacttct ttttcactga tctctgtttt 3456421 cggaatggag atatatctct gattgctctc atcaaaaaaa catagacagc cttcccttat 3456481 gcaaagctcc tcagacacaa tcgaaccggg ataaatagcc agcagcgatt tcatagagtc 3456541 tcctctctta tgtaaggatc tgtatattca gtataaggcg aaacacacat gttctccact 3456601 aaaaaagagt atatccggta tagatagacg agaaactgaa agggaaacct cattcgttta 3456661 catattggct tcagcggaaa tagaagaaga catgcaggac caaaggaggg tcatcttatg 3456721 agtttcgaaa cgttaaacaa aagttttatc aacggaaaat ggactggggg agaaagcgga 3456781 cgtacggagg acattttgaa tccgtatgac cagtctgtga tcacaacagc atctttggca 3456841 acgggcaaac agcttgagga tgcgtttgac attgcacaga aagcccaaaa agagtgggcc 3456901 aagagcacga cggaagaccg aaaagccgtg ctgcaaaaag cgcgcggcta tttacacgaa 3456961 aaccgtgatg acatcattat gatgatcgcc cgcgaaactg gcggaacgat cattaaatca 3457021 acaatcgagc tggaacaaac gattgcgatt ttagatgaag ccatgacgta tactggtgaa 3457081 ttaggcggcg tcaaagaggt gccatccgac attgaaggga aaaccaataa gatttaccgc 3457141 cttccgctag gtgtcatttc atcgatttct ccatttaatt tcccaatgaa tctatccatg 3457201 agatccattg cgcccgcaat tgcgctgggt aacagcgttg ttcacaagcc tgatatccaa 3457261 actgctattt ccggcgggac catcattgcg aaagcgtttg aacacgccgg tcttcctgcc 3457321 ggtgtcctta acgtcatgct gacggatgta aaggaaatcg gggacggcat gctcaccaat 3457381 ccaatcccga gattaatcag ctttacaggg tcaacagcag tcgggcgcca catcggtgaa 3457441 atcgccggtc gcgccttcaa acgaatggca cttgagctcg gcggcaacaa tccatttgcc 3457501 gttctttcag atgcggatgt cgatcgtgct gtggatgccg cgattttcgg aaaatttatt 3457561 caccagggac aaatctgtat gattatcaac aggatcatcg ttcatcaaga tgtatacgat 3457621 gagtttgtag aaaaattcac cgcccgtgtc aaacagcttc cgtacggcga tcaaaccgat 3457681 ccgaaaaccg ttgtcggccc gctgatcaac gagcgccaaa tcgagaaagc gctggagatc 3457741 attgagcagg caaagacaga cggcattgag cttgcggttg aaggaaaacg cgtcggaaac 3457801 gtgctgacgc cgtacgtctt tgtcggtgcg gacaacaaca gcaaaattgc ccaaacggag 3457861 ctgtttgccc caatcgcaac cattattaaa gctggcagcg accaggaagc gattgacatg 3457921 gcaaatgata ctgaatacgg cctcagctct gcggttttca cttctgattt agaaaaaggc 3457981 gaaaagttcg ccctgcaaat tgacagcggc atgacccatg tcaacgacca gtccgtcaat 3458041 gattcgccga atattgcctt tggcggaaac aaagcaagcg gtgtcggccg tttcggcaat 3458101 ccgtgggtcg tcgaggaatt taccgtgacg aaatggattt cgatacagaa gcaataccgc 3458161 aaatatccgt tctaaatgaa aaaatccctc tgtttcaagt acagagggat ttttctttat 3458221 ttagatatat ccacaaaccc ttcgccaaac acatcgcgta cgtcatgtac gatcacaaac 3458281 gcttttttgt cgcagcttct aatgattttt ttcagcatag acagctcctg tttgttaatg 3458341 acgatataca aaatctcttt tgactggccc gtataatttc ccttccctga taaaatcgtc 3458401 acgccccgat ccatcaaggt atttacctgc tctgcaatct cactcttatt ttctgaaatg 3458461 accgtaatgg cttttttcgt attcaaacct tcaataatga agtccatcac tttggtaccg 3458521 atatacagca tcacgatcgt aaacatcatt ttttctgcac caataataaa ataagagcta 3458581 aatactacga ttaaatcaaa aaacaagagt gcatagctga tattccagtc taaatattta 3458641 ttagcaattc tggccagaat cgcggaaccg gccgtcgtcc cgccgacccg gataatcatg 3458701 ccgatcccga ctccggcaaa tacacctgcg aaaatcgtat taatgatcaa ttcatcagac 3458761 ggaatgctcc acccatgtgt cagatgaaga aaaagcgaat ttgccgcaac cgcaatgatc 3458821 gtataaaccg ttgtttttcc atcaagaaac ttgtagccga ttaaaagcaa aaacgcattt 3458881 aagataaagt tcgtgacacc aggagaccat tgaaacagat aatacaaaat cagcgtaatc 3458941 ccagtgactc cgccttcccc aagatcattg ggaatcgcaa ataaattaac cgcaagcgcg 3459001 aagaaaaaag cgccaatcac aagcataagt acatccagca ttctcttttt catcacgaaa 3459061 acactccttt tcattgttct gttctagcaa ataaaaaaac ccaggagaac gctctcgaaa 3459121 aagagcagaa actcctgggc ttttatccca ccgtgtcata acagccaagc tgctatgtgt 3459181 tttctctcgg tcacagtcca atttgcattg cggaacccta gaaaaccact gtttttatca 3459241 tatccttttc actttccaat attagcatta taagggacgg ttcgaattgg ttcaaggggt 3459301 atttgcggag ttttcatcag ataagctgga aaaaaatacg atttatctat taaaaaagaa 3459361 cagatataac cgataagaaa aaaagcatat attttacaag cgaatgtaac tataaatgat 3459421 aataattata agaaattcat aattttatat tgactaagag aaataatata ggcattatag 3459481 tacatatgtt tcgtacattt tattacatag gaggaaatat aatggcagga aaactagtac 3459541 cctgtaaagc ttgcggtcaa gaaattgcaa agggtgtaaa aaaatgtcct aactgcggta 3459601 aggatcaacg taactttttt atgcgacata aaatcattac gtttattctc gcagttgttg 3459661 tcatcattat tatcggtaat atgattggcg gcggaggcgg ctcagaagcc acttccaaaa 3459721 catcaagcag cagcaaagca gaaactgaaa aaacatacaa tatcggtgat accgtaaaaa 3459781 ctgaaaaaac tgaagtgacg gttacgaagg tagaggacag agatactgtc ggtactcaat 3459841 atgttgaaaa gaaagcatct gagggaggta caattgtagc tgttcaatat acaattaaaa 3459901 acgtatctaa aaagccgatt agctcttttt caattccaac tgttaaatta gttgatgctg 3459961 atggtacttc ttatgattct gatattgatg cttctgtaaa ctatgcaact gagacaaaag 3460021 ttgataactc taaaattttg agtgatctaa atcctaatat taaagtaaca ggtgtaaaag 3460081 catttgaagt tgacaaggaa gcttatgcaa aaggcacttg gaaactaaaa ttcagtaatg 3460141 atgttattgt gaaaatcaaa taacagctaa caagggtgcc tgtttaggca cccttgttct 3460201 ttaaaaaagg ccttctcaat tgagaaggcc tccattctta ttccgcactc ttatacccat 3460261 tcacattaga agactgccat ctccaggaat cagcacacat ttcctcaagg ccgcgtttcg 3460321 cttcccagcc tagttctcgc ttggctttcg caggatctgc aaagcatgtg gcgatgtctc 3460381 ccggacggcg gtccgcaaaa cggtatggaa cctctttccc tgacactttt tcaaaggctt 3460441 tgaccatttc cagcacgctg tagcctgtgc ctgttccaag gttgtatgca tcggctcctg 3460501 tagagttcaa tactttttcc agcgccttga cgtggccttc tgcgagatca acgacgtgaa 3460561 tataatcgcg tacgcctgtc ccgtcttttg tcggatagtc atttccgaat acgcttaatt 3460621 gctcgagctt cccgactgct acctgtgcca catacggcat aaggttattt gggattccgt 3460681 tcgggtcttc accgatccgt ccgcttggat gcgcgccgaa cgggttaaag taacgaagca 3460741 gcgcaacgct ccactcattg tcggctgtat gcaaatcacg caatatttgt tcaagcatga 3460801 gcttcgtctg cccataagga tttgtcgcgc ctaatggaaa gtcttccgta atcggcgatg 3460861 tttccggaac gccgtatact gtcgcagatg aactgaatac gattttcttg acgccgtatt 3460921 tctccatggc ctcgcataaa ataaacgttc ctgtcaaatt gttatgataa tatttgaggg 3460981 gaatcgccac agattcgccg actgctttta accctgcaaa atgaatcaca gcttcgattt 3461041 cattttcagc aaaaacggaa tctaccgctt cccggtccaa taaatccgct tcgtagaacg 3461101 ttaaatcttt tcctgtaatc tccttgacac ggttcagcgc ttcagctgaa ctgttggaca 3461161 gattatcaag aacaacaatc tcgtagccgc tgttcaatag ttcaacacat gtgtggctgc 3461221 caatgtaacc ggcaccgcca gtaacaagta ttgccatgat gtaaaccctc ctaaaaaatg 3461281 acctgttttc attatatagt gtttagaacc ggtccacatc catttttaag aagtttaatc 3461341 gtttattaat agttttttca tattttttag cttaaaccct tgccagcaat tcgatagagg 3461401 tttcagcaag aatgtgctct ttcatttctt gatagagctc attcaagtaa aagcccggct 3461461 gaagattcag ctcagcatct aaagcataga ccgtcaatgt atacgcatga tccttgtcag 3461521 gcggtgtcgg cccgcaatac tggtgaatca cctttggatc gttgcttccc gcaagcggtg 3461581 aagcaaagct gttttgccct tgtatcatca agtcctgtct ttcctcactc gcatgttcag 3461641 gaagctctcc gatgtaagcc ggaatattag ccgctgtcca gtgaatccag ctgaatccgc 3461701 atacgggaat ggcgtcatga tcgatgaaag taagtgcgag cgtctttgct ccggacggga 3461761 tgtcatcaaa atgaattgga aaggatacaa atgggtttcc ttctctctta tatttttcat 3461821 ccgcgtattt tgaatacttg tcatgtaaat atggatttgc ttctacgtat atgttcatat 3461881 gaatccctct ctctattttc tcgttctata ggtatactaa acgaatcgat gtataatcag 3461941 tgataaacaa atacgcatgt aaacgtaaca atttgttatg gataacttgc agtgaaggag 3462001 atatttcatg gatttaaaat ggctgcaaac ctttattgcc gcagcggaat cagagagctt 3462061 cagggaggcg gctgagcatc tgtatctcac acagcctgcc gtttctcagc atatgaggaa 3462121 attggaagat gaactggaca tgaggttgtt tttgcatagc ggaagacgag tcgtactgac 3462181 tgacgaaggc aggctctttt tgccttatgc caaagaaatg atccatgttt accaagctgg 3462241 aaagcagaaa gtcagtcaat ggaaacaggg gtacagccga tcactcacgc tggccgtaca 3462301 cccctacatt gcgtcctata tcttgcctcg ctttctgcca gcctatatcc aaaaacatcc 3462361 gcatgtcgag ctttcaactc atgtggctgg atctgacgct attaaacaag cggtggaaca 3462421 caatgaagct gatattggtt tgtcgcggaa agacccgaac accaacactc tttattatca 3462481 gcatatatgc gaaggtacgc tttgtctggc ggctcctttc caagaaagca gaccggatgc 3462541 tgcatccgtc ttaacccgct atcggctgct aacgcatgat catccgtcat atggggatgc 3462601 ctttttagat aacatccgat cacattaccc gtatcttcaa atgatggctg tcgggcagac 3462661 ggatacggct gtccacatga tgaaagcggg aatgggggca tctttcctcc ctacctacat 3462721 tatcaaacag gaagaagccg aaaaaaagct gatggctgtc agcacgcctg cacatctaga 3462781 attgcctgcg tcccaaacgt ttatgatgtg gaaaagaaac agcgaagaca ttcagcattt 3462841 tcacgccatg ttacatgact ttatgcagcg cgaacaagta tagagctgaa aaatcaatct 3462901 gccggttgac gtttttcttt cctattttcg ctatgcttaa tgcagaaagg atttgatgac 3462961 atggcgatga gcccttatat ttttattgta ttgattctta ttattttatc gatgtatcga 3463021 gaaagaacgg taaagcccgg gaagttgctg atcattccac tgttgctctt atggggcgta 3463081 tctgcatcgt ttcagccggc gtattttcat tccgtattac atgtggcgat cagcggcatt 3463141 ttattactga tcgggctggc ctgcgggttt ggcattggga agatggtaaa tgtacggatt 3463201 cacccggaaa ccggaaaggt cacttcacgc ggctcacttg ggagtgttat cctcattcta 3463261 gtgatacttt ctttgcgcat ggccgcgaga acatggctgc ctgagagcaa cgagatgttt 3463321 attgccatta ttcattctat gttcttcgtt cccctcggca ccatcacagc ccgcaacatc 3463381 atgctttaca aagcatacag acgactgacc gctggcaaag tatccattca ataaccgaaa 3463441 gaaggaccag catgaacgga caaactccgg ctcggcacta ctacaagaag cttgtgccga 3463501 gccttattct cattttgaat tgcatacaat ttttatctca tccaactaag gctgatccca 3463561 ttttgttagc atttgtattt gcggtatact tagcattcat ttggatcatt ccctatgtgg 3463621 catccactgc tgttagtttg agcatattca tcggactctg gctcctgacc gatttctttt 3463681 gggctgtttc cggccaagag cagggtgccg cctatttttt gattgtattt ttaatgatat 3463741 atgccgcctt tagactccct tcacggctat ccttgatctt cacagcatgt ttaattggag 3463801 gcaacatatt actcctatcc tcacaagggg gaagcttgaa taccatcatc agcaacatct 3463861 cgatcatgct cggtctgtac gtcctcttct cctccatgcg tttcagacga gaagcgagaa 3463921 gggaggctga acggaatcat gctgaattgg caaaaatgca tgtgcagctg gagcatgctc 3463981 ataaagaact ccagaaagcg catgcagagc tgcaggaggc ttctgttctt tcattaaggt 3464041 acgcggtcct tgaggaacgt acaagaattg cccgcgacat tcatgacagc atcggtcacg 3464101 agctgacttc tgtgattgtt cagcttcaat cccttcccta tatccttaaa agcagcaagg 3464161 aggattcaga aaaagtcatt caaaatgtac tgagtgtcgc cagggagtgt cttcaagaag 3464221 tgcggtctgt tgttcaccaa atgggccgta gtgaatcgat ggtggggctt accgctttgc 3464281 gggggctcat tcatcaagtg gaggaacgga gcggcttgca cgtttcttta gatactgccg 3464341 gactgtcaga agagtcttgg cctccaaacg tgagcgaaac gatctaccgc atcttgcagg 3464401 aagcgctgac caatatcatt cgtcacgctg acgcttctca tgcggcggcc gtcatttcta 3464461 atgacaagtc ccatctctat gtcacaatca ccgacgacgg acaattcacc ggcagcctta 3464521 cttatggatt tggcctgaca ggaatgaaag agcgcgcaga aaaagcaggc ggttccctta 3464581 ctttcagtgc cgtacagccg agcggcctga aaattgagct gtcattgccg ctcatgacaa 3464641 cgaataagga gcaaaaagat gaacaaagat aaaatacgcg tagcgcttgc cgatgatcag 3464701 ccgcttgtgc gtgaaggctt ccgctacgtc atcaacgcac agacggatat gacggtttct 3464761 ggcgaggccg gcgacggtca cgatattata gcactcgcaa aacaaacaaa acccgatgtc 3464821 atcctcatgg atgtccagat gccgcgttgc tcaggcatcg aagcggcgaa agacattatg 3464881 tccgcacttc caaatacaaa gatagtcatt ttaaccacct ttgacacgga agaatacgta 3464941 tttgaaggca tccgtgcggg cgcagtcggc tatctgctga aggatacact tcctgaggag 3465001 ttgatagatg cgattcgcgc tgcggccaga ggcgaggcga ttttccgtac agtcacagct 3465061 gctaaaatca tcagtgagac atttcgggcg aaacagcaaa ctcatgccga agaactggca 3465121 gagccgttca ccaaaagaga gcttgaggtt cttcagcaaa tggcctacgg actgagaaat 3465181 gaggatattg ctgaaaagct tttcgtcagt gaaagcactg tgaaaaccca cgtgcaccgc 3465241 atcctgcaaa aatgcaatgc ccaagaccgg acacaggcag tcgtttttgc cattcgaaac 3465301 ggtattgtgc aatagaaatc tctcatcccg ccatgctaaa ataagacaaa ggagatgatt 3465361 ggaaatgaaa gaagaaatca ttgaacggtt tactacatat gtaaaagtcg atacacagtc 3465421 cgatgaatcc gttgacactt gtccttccac acccggccaa ttgacattag gaaacatgct 3465481 agttgatgaa ttgaagtcca tcggcatgca ggatgcagcc attgatgaaa acggctatgt 3465541 catggcaact cttccctcca atactgaaaa agacgtgccg acaatcggct ttctcgctca 3465601 cgtcgacacc gctacagact ttaccggcaa aaatgtgaat ccgcaaatca tcgaaagcta 3465661 tgatggaaaa gacatcgttc ttaacgaaca gctgcaggtc accctgtcac ctgatcaatt 3465721 ccctgagctg tccggctata agggccatac actcatcacc acagacggca ccacccttct 3465781 cggcgcagac aataaggccg gtatcgctga aatcatgaca gccatggatt acctcatcaa 3465841 acaccctgaa atcaagcacg gcacaatcag agtcgccttt acgcctgatg aagaaatcgg 3465901 aagagggccg cacaaatttg atgtgaaacg gttcaatgca tcctttgcct acacggttga 3465961 cggcgggccg ctcggcgagc ttgaatatga aagcttcaat gccgctgccg caaaaattac 3466021 gattaaaggc aacaacgtac atcccggaac agctaaagga aaaatgatca actctgcgaa 3466081 aatcgcgatg aagctgaaca gcctgctgcc ggcagacgaa gcgcctgaat atacggaagg 3466141 ttatgaaggc ttctaccacc tgctgtcgat tcaaggagac gtagaggaaa caaagctcca 3466201 ctacattatc agagactttg acaaagagaa tttccaaaac agaaaagaaa caatgaagcg 3466261 tgccgttgaa gaacttcaaa acgaatacgg gcaagaccgg attctgctgg atatgaacga 3466321 ccaatactac aacatgagag agaaaattga acctgtcatc gaaatcgtca acattgccaa 3466381 gcaagcgatg gaaaacctcg gcatcgaacc gaagatttcc cccatccgcg gcggaaccga 3466441 cggatcacag ctgtcctaca tggggcttcc gacgccaaac atctttacag gcggggaaaa 3466501 cttccacggc aaatttgaat acatctcagt tgacaacatg gtcaaagccg taaatgtcat 3466561 cgttgagatt gcaaagcagt ttgaagcgca agcataacgc caaaagccag tccaaaaaag 3466621 gactggcttt tttgtgtgaa aatgaaacat tttaaacacg tcctccgtaa aacaagtatc 3466681 aacaaatgag gaggaaaaac aatgacaaaa catgcaatcg ctgccaagag tctcttgaaa 3466741 aaatggatca tttccaggcc gcttaacatg aaaaagaaat ccagcccatt tcaaaaaatc 3466801 agaaaaatgt tcaaacgctt cttcaaataa aacatcaaat cccctaaata caatccgtat 3466861 tcacccgtac cgcccaaatg ctccgtaatt tgggtttttt gtgttcaatt ccgcaaaata 3466921 gggtataaac caaacaagca agaaaacagc acccaaaaac aggtaattcg aattacgtaa 3466981 acttaggtta aaagttatat aaaggaattt attttatcgt cgatagtaac tatagaacca 3467041 atcatcaaca agagcaaaca gcgtaattca agactatttt caggtcatca ggtaatactg 3467101 ttttagaggg acagtttctt gttatttatt gatttagaat tttttgaata ctttttggca 3467161 ttttatccgt acaatagaga gtaccaaaac tttttttggg aggtatgtaa tatgatccta 3467221 tttattatca tcgcattatg cggctatctt cttttttctt tcagcaagga caatcgccgc 3467281 aaaccgcaaa agacaagccc tctgccagca gccgcacctc atcacaacaa cctaatcgac 3467341 cttgacgcca tccgccaaaa acgccggatg catctttcct aattctatat ttcaaacgaa 3467401 aaggctgctg aatcacgcag ccttttaaaa ttgttttgat ttagagcctg aaaccttttc 3467461 gccacctatc cgtaatttca tacaaggcaa acccaaagga gacttcagca atgatcgagt 3467521 tatttatgaa acaaaaaatg ttctcattta aagatgcatt tcacatttat gaccgggatg 3467581 aacaagaaac attcaaggtg gaggggcgtt ttttctcgtt aggagactca ttacaaatga 3467641 cagactcatc tgggaaaacg ctcgtttcca tagaacaaaa actaatgtct ttattgccgc 3467701 gctatgagat ttcaattggc gggaaaacag tttgtgaggt aacgaagaaa gtaacgtttt 3467761 ccaaaccgaa atttgtgatt tccgggctta actgggaaat agatggtgat ttatggaggg 3467821 atgaattcca actgacggac ggggaaaatg tccggatgtc agtgagcaaa aagtggctca 3467881 gttggggtga ttcctatcac ttgcagattg catacgagga agatgttctg atttgcactg 3467941 ccatcgctat cgtgcttgat atggttttat ataacgatga agatgaaagt attttctaaa 3468001 aagcattgac aattgatcca aaagtaataa tattaagata attgaaatct gaatatgaag 3468061 ttgtacctta tcaagagagg tggagggact ggccctatga tacccggcaa ccgctgtttc 3468121 aaacagaatg gtgctaaatc cttaagaaca ttgcgttctt gcagatgagg cggagatttg 3468181 atcgttcaag ctcttcctta cacaaaggaa gagcttttta catgcttaat atttcagaaa 3468241 agaggcgaat aacatggctc aacaaacgaa tgttgcagga caaaaaacag aaaaacaacg 3468301 caaagcacct ttccgcgccg atcatgtcgg cagcttgctt cgttccgttc cggtaaagga 3468361 agcccggcaa aaaaaagcgg ctggtgagat gacagcggaa cagcttcgtg atatcgaaaa 3468421 tcaagagatc acccgcatcg tggaaaaaca aaaagaaatc ggtctcgatg tggtaacaga 3468481 cggggaattc cggcgttcct ggtggcatta tgacttcctg gaagggcttg acggtgtgga 3468541 accgttcatc ccggctgagg ggattcagtt ccataacaca aaaacgaaag cgcgcagcat 3468601 caaagtgacg ggaaaactcg attttacgag ccacccagcg ctcggtgatt atcaattttt 3468661 acatgagatt gccggtaacg cgacgccaaa attgaccatt cccagtccaa atatgctgtt 3468721 ttttggcgaa aaggcggata aagggattta tgacgatcaa gaggaatact ttcatgatat 3468781 ggcccaagcg tacaaaaaag caatcaaagc cttctatgat gctggctgcc gttatctcca 3468841 gcttgatgat acgtcatggt ctctcttctt tgaggacaaa ggcagagagg ttgtccgggc 3468901 gctcggcggt gatccagaaa cattgccagc catatttgcc aaaacaatta acgatgccgt 3468961 cgcagaccgg cctgacgatt taacgatcac aatgcacatt tgccgcggca acttccgctc 3469021 aacctgggcg gcatcaggag ggtacgacgc tgtagcggaa acgattttgg acggcttaaa 3469081 ccttgacggc cttttcttgg aatacgatga tgaccgctcc ggaaactttg atccgctccg 3469141 ttttgtgaag cgcaaggatc tgcaaattgt gctcggcttg atcacatcga aatacggcga 3469201 gcttgaaaat cctgaggatg tgaaacgccg tatcaatgaa gccgcgcgtt ttgtcagctt 3469261 ggaccagcta tgcctgagcc cgcagtgcgg tttcgcctct acagaagaag gcaaccttct 3469321 gacagaggag cagcaatggg caaagctgcg ccatgtcatc gacattgcca acgatgtgtg 3469381 gagataatct atcattgaca gaaatagaaa atgtgtgaat aatagatact atcagaaaat 3469441 ttaataaaaa ggttttcctt atcaagagag gtggagggac tggccctgcg atacccggca 3469501 accgctgttt aacagaatgg tgctaaatcc tttagagcaa tgattgctct tgaagataag 3469561 gttgagattg tcacgcaagc tcttccttat ccaaaggaag agctttttta tatttgaatg 3469621 gaaagaagga atggacaaca tgtcacaaca aacaacaccc gcagaacaaa aatcacttca 3469681 aagaaaaaaa ccgccgtttc gcgcggatca agtcggaagc ctgctaagat ctgagcccgt 3469741 caaaaaagcg cggctgcaaa aagcggccgg cgaaatgacc gctgagcagc ttcgccaaat 3469801 tgaaaacgac gaaatcatcc gcattgtgga aaaacagaag gaaaccggcc tgaacgtcgt 3469861 gacagacggt gaattccgca gagcatggtg gcactttgat ttcctggaaa acttagatgg 3469921 cgttgagccg tttactcctg agcaaggcat tcaattccat aacgtacaga caaaagcacg 3469981 cggcattaaa gtcacaggcg atatcgactt ttcaactcac ccaatgcttg aagattactc 3470041 atttctccat agcattgccg gtgacgcgac gccaaagatg acgattccaa gtccgaatat 3470101 gctgtttttc cgcggaaaac tggaaaagga tgaatacaaa aacgattatc aacttttcca 3470161 gcacgatgta tccaaagcat ataaaaaagc gattcaagcg ttttatgaca gaggctgccg 3470221 ctacctccag cttgatgata cagcgtgggc cgttttctta tcagaaaaag gcttaaaaca 3470281 aatcgaagcg ttcggaacaa cgcctgacga gcttcgccag ctgtttgcga aatccattaa 3470341 cgacgcgatt gcagaccgcc cggatgactt gacggtaacc atgcatattt gccgcggcaa 3470401 cttccagtcc acttggacag cggaaggcgg ctatgacgca gcagccgaaa ccatttttga 3470461 cggcttgaat cttgacggac ttttcttaga gtatgatgat tcacgctcag gcggatttga 3470521 gccgctccgt tacgtaaaac ggtctgatct tcagcttgtt cttggcttag tgacatctaa 3470581 attcggtgag cttgaaaatc cggatgacgt gaaacgccgt atcgaagaag cgtcccgtta 3470641 tgtaagctta gaccagcttt gcctcagccc tcaatgcgga ttcgcttcaa ctgaggaagg 3470701 caacaagctg actgaagaac agcaatgggc gaagctccgc catgtggttg agatcgctaa 3470761 tgatgtttgg aaataagcaa agaaaaaaac acacttgatt ccctagcgga gcaagtgtgt 3470821 tttttatgtc attgtgcggt gtagccccca tcaaggacga cagcctgccc agtgacgccc 3470881 ttcgccttct cgcttgccaa aaacacggca taatccgcaa tttccttgac ggaaagcagt 3470941 cgcttttgcg gcacaagcgg aaaaatgact tgttcaagta cagagtcgta agggacattt 3471001 ctagttttcg atagatcgct aagctgattg cgtacaagct gggtatcgac ataacccgga 3471061 cagagcgcat tgactgttat gccgtggggc gcgccttcca gcgcccctac ttttgtgagt 3471121 ccaatgacgc cgtgcttggc gctattataa gcggatttcc ctgcaaagcc cactaatcca 3471181 ttaacagacg caatattaat gattctgcca aactgctgtt ttttcatgat cggaaaaaca 3471241 tgcttcattg caataaaggg agccgtcagc atgaccttga tcagctgttc aaaggtgtct 3471301 gtcggaaact cttcaatcgg agcgacgtgc tgaataccgg cattgttcac cagaatatcc 3471361 aagcggccgt attgtttttg gatgacgttc accgtatcag caacttgcgc ttcctttgtc 3471421 acatcatacg gaatggccgc cgcgtcaaag ccttcttctg caagcttgga ggctgctttt 3471481 tcacatgctt ccggacggag gtctgaaacg atgacgctgg caccttcccg ggcgaattct 3471541 cttgcgattt cgaatccgat tccgccggca gcccctgtca ccaaagcgac ttgttttctc 3471601 atgtcaaaca ccttcccatt aagaattgag tacagactgg cttacagcga aatcagcttc 3471661 tgttttttca taaacctctt caattgtgac accatcctga agctccgtca gtgtcatgcg 3471721 gccgttcaca aaatcaaata cagccaaatc cgtaatcagc ctgtgtacga ctttctggcc 3471781 tgtcagcgga agggagcatg tttttttcac ctttgattca ccatgcttat tgacgtgctc 3471841 catgatgaca acgattcgtt tcgccccgtt gacgagatcc atggcgccgc ccatcccttt 3471901 taccattttg cccgggatca tccaattggc caaatccccc tgctccgaaa cctccattcc 3471961 gccgagaata gctaaatcga tatgcccgcc tcttatcatc gcgaatgact cagcgctgtc 3472021 aaaataagag gcgcctgtca cttcagtgat cgtttccttt cccgcattga tcaaatccgc 3472081 gtcttccgtt ccttccagag gataggggcc aattccgagc aagccgtttt ccgactgaag 3472141 catgacgtga acgccatcgg gtatctcatt tgcgacaagc gtcggcattc caatcccgag 3472201 attcacattc atgccgtcct tgatttcttg tacagcccgt ttgaccattc gttttctcgc 3472261 ttccttcact tggcctcacc ctttcccgat gcttgctgaa ctgttcgttt ttcaatccgt 3472321 ttttcttggc tcgcgccaag cacgacatgc tgtacgtaaa ttcccggcgt atggatgtga 3472381 tctggatcga gctctcctgc ttccacgatt tcttccgcct cggcaatcgt gatcttgcct 3472441 gccatggcgg caatgggatt gaaatttctc gccgttttcc taaaaatcaa attgcccatg 3472501 gtgtccgctt tccacgcttt gacgatcgcc acatcgccgg taatgcctcg ctccagcaca 3472561 taagtccggc cgccgaatgt tttatgttct tttccctcgg ctatggaggt gccgacgcct 3472621 gtcgccgtat aaaatcccgg tatgcctgca ccgcctgcac gaattctctc agcgagcgtt 3472681 ccttggggaa caagctctac ctcaagctct ccgcttaaaa actgccgctc aaaaatttta 3472741 ttttcaccga cataggaagc gatcattttc ttgatttgct tgttagccag aagcaaacca 3472801 agcccccagt catcgactcc gcagttattg ctgacaacgg ttaaatcctt tactccctga 3472861 tctcttatag acaaaatgag ctgttcaggg atgccgcaca gcccaaaccc tcccgcgatc 3472921 agcgtatccc catcatgaat cagtttcgca gcttccttgc ttgatgacag cacttttccc 3472981 atattgatgc ccctttcgtt ttcttctaca ctagaccagt caggctgtaa atcgcgatca 3473041 cagcaaatac ggcagccgtt ttaatgagcg tgatcgcaaa aatatcgcga taggattgcc 3473101 ggtgggtcaa acccgtcacg gccagaagcg tgataacggc gccattatgc ggcagtgtat 3473161 ccatcccgcc tgatgccatt gaaatgaccc gatgcatcac ctctggcgga atattgtaag 3473221 cctgaatcgc ctgtaagtat tgttctgaca tcgcgcttaa cgcaatgccc attcctcccg 3473281 aagccgagcc ggtgattccc gccagcgcag ttgtcgtaac ggcgccattt acaagcggat 3473341 cggtaaaagt atgtgaaatt ccgctgctca gcttatgaaa ccccggcagc gcggcgataa 3473401 tgccgccgaa cccgtactca gcacccgtat tcatagatgc cagcaaggcg ccgccaattc 3473461 cttcattcag cccttccttc aattgggcaa acacacttct ccaatcaaat aatatcgttg 3473521 tgatgatgcc aatcactaaa gcaatctcca ccgaccaaat agcagccgct gaagaaatat 3473581 caagcctgcc gaactccttt aatcctatgg aagaaaaatc aaatccattc ggataccact 3473641 ttggcaggta aatggtgaaa tatttattca ctgcaccgac gagaataagc gggacaaagg 3473701 caagcgcgtg ccgaatcggg cttttgtccg gttcagccgc ggactcaatc gattcaggag 3473761 caggagcatt ctgcgaatca aaaccgccat agccttcgcc agatgcctgc gctttcttcc 3473821 gccttgattc caaatagagc atcccagctg ccagcacaat cactgcgccc atcaaaccca 3473881 gccaaggggc ggcataaatg tctgttttga aaaacgacgt cgggatgaca ttttggattt 3473941 gcggcgttcc cggaagtgcg tccatcgtaa acgtaaaagc tcctaaagca atcgtacccg 3474001 ggatgaggcg ttttggtatg tttgcttctt ggaacatgtt tttcgcaaaa ggatatacag 3474061 caaatacgac aacaaacagg ctgacaccgc tgtacgtcaa gacagcaccc atcagcacaa 3474121 tggcaagtat cgctcttttt gccccgacaa gccggacaat tgttttcgcg attgatgccg 3474181 caagcccggc catttcaacg acctttccaa aaatagcacc gagcaaaaac actgggaaat 3474241 acagcttaat aaaacccgcc atcttctcca taaaaattga tgaaaaaaaa ggaagcacat 3474301 ggcttggatc tgtcagcagc accgcgaata acgcgcaaat cggcgcaaac aatatgacag 3474361 aaaatccccg atacgccgta aacatcagca aacctaacgc caatagaatg atgatcagtt 3474421 ccacacacac atcccccgtt tccgcgaact agaaagcgtt tacaaaaacc tgtccgcatc 3474481 ggctgtttcc gtcccctttc catatgtacg agaagcgtgg gccaactatt ccgattaaaa 3474541 aaggaaagct ccttttttcg gagctttcct ctaccattca tttcattcct attaggatat 3474601 caacatcaac cgtaatatcg gctgatttca tctctttcag caggctgact cgatctttcg 3474661 gcgccgacca ggcaagcggc gtcatcttga gaagccagtg gatcgcctgc tggtcaagcg 3474721 ttttaacata gcgcagcctg acaggacggc tgtgtgctgc atttgctgta aaacgctcaa 3474781 ctgctgccgt attggaatac gtgcgccttg gtgaatcagt atataaaaat tgccttaatt 3474841 ctattaaata gtcgcttcgc ggcactactt ttatgagcat gccatcattc ttcagcagtc 3474901 tatgaaactc tgcataattg gacggcgaaa aaatagacag aacaacatca aattggcgat 3474961 catgaaaagg agcacgcgcc acatcggcaa ccgcccacat cagatctttg aatgccttag 3475021 aagcttttaa gatcccgtcc ttcgaaagat ctatgccggt tcctatcgct gctttccctg 3475081 cataatcaaa cccgcaaagc gcattcaaat gagaaccctc accgcaaccg ctgtccaaga 3475141 tggtgaatgc ctcatgacca gatttgggat gactgatgag ctctgcaatc gcatcatgga 3475201 gcgggtcaaa aaaaccacat tctccaatca gcctgctcct cgcttcaaaa agctcggcac 3475261 cgtaactggt tttgaccggc ttcgtcagaa agttcacgta gccgtgccga gatagatcaa 3475321 atgtatgtcc tcgttctgta caaatcaagc ttttccctga tgccgcatcc atagaagaat 3475381 cgcagagcgg gcatcgaaac atgctgaaat caactgttcg cttcatgata aaaaacaccc 3475441 cattcattca tttttagata aatgaaaaag gcatagacaa ataaacctag gcctatctca 3475501 aaaattggcc aggtctggca gtttgtctac acctgtcatt atctataacg aatgaattgg 3475561 ataatcatga aaaaaactcc ctttctgctg tatgggtttc cccgtttcca tcatacaaca 3475621 aatatccagg agctggaacc ttatagtgaa gaaaaatcag tactgacatg ctggtatccc 3475681 gccaacatca tatcagcata gcaatccagc atgtttttcc tttattttct cattttagaa 3475741 tataaatttt attattgtga aaatagttaa aaaggttgat tttcaaaaag tgaaaggata 3475801 aaatactgct atcatcttag aaaaagacat tcttgtatat gatcagtaat atggtctgat 3475861 tgtttctacc tagtaaccgt aaaaaactag actacaagaa agtttgaata aatttgaacg 3475921 agttgaaaag gacaagttct tttctgtttg ctcttatttt tcacactttc tgcacttcca 3475981 gaatttgtga aggataagag ctttttttgt ttccataata accctcatag gagttgctat 3476041 catgtacttt ttactaaacc ttgtcggtct cattgtgatt atggcagttg tattcctatg 3476101 ttctccgcag aaaaagaaaa tcaagtggcg cccgatcatt acgttaattg ttctggaatt 3476161 gctgattact tggtttatgc tgggaacaaa agtcggaagc tgggccatcg gtaaaatcgg 3476221 tgatttcttc acttggctga ttgcttgcgc cagtgacggt atcgcgtttg cctttccgtc 3476281 agtgatggcg aatgaaacag tagacttttt ctttagtgcg cttcttccaa ttatctttat 3476341 cgtcacattc tttgatattt taacgtattt cggcattttg ccttggctga ttgataaaat 3476401 cggatgggtg atttcaaagg cttcccgctt gccgaaatta gaaagctttt tctctattca 3476461 aatgatgttc cttggaaata ccgaagcact tgcggtcatc cgccagcagc ttacggtttt 3476521 aagcaacaac cgcctgctca cattcggttt aatgagcatg agcagcatca gcggctccat 3476581 tatcggatct tatctttcaa tggtgcctgc gacatacgtg tttacagcca ttcctttgaa 3476641 ctgcttaaac gcgctgatta tcgcaaacct gctgaatcct gttcacgtgc cggaggatga 3476701 agatatcatc tatacaccgc ctaaagaaga gaagaaagac tttttctcta cgatttctaa 3476761 cagtatgctt gtcggcatga acatggttat cgttattttg gcaatggtga tcggatatgt 3476821 cgcattaacg tcagcagtta atggcattct tggcgttttc gtacatggcc tgaccatcca 3476881 gacaattttt gcttatctgt tcagtccgtt cgcattcctg cttggactgc cagtgcacga 3476941 tgcgatgtat gttgctcagc tgatgggcat gaaattagca acgaacgagt ttgttgcgat 3477001 gcttgacttg aaaaacaatc tcaaatccct tccgcctcac accgttgcgg tggcgacgac 3477061 attcctgacg tcctttgcaa acttcagtac tgtcggcatg atttacggca cgtacaattc 3477121 gatccttgac ggagaaaagt caacggtcat cgggagaaac gtgtggaaac tgctcgtcag 3477181 cggaattgcg gtatctttat taagtgctgc gattgtcggc ctgtttgtgt ggtagaaaca 3477241 ttgagccata tcccttttcg gatatggctc ttttcattat tgataaatag aggctggcac 3477301 ctgcacatcc cggattcccg ctgcataagg ccccaagtca tactggccga agacgatggc 3477361 gatcccgttt gccgtaaagt aaaacattgt gtctctgttt agggttatat cctctttctt 3477421 tacatcagag aaaaacagca catcgtgttt tttgatatag ctatataggt aatctctcgt 3477481 tttgctgact tttgttttgg tgttcagaat ctgatccagc gtcacccgct tttgtgcttt 3477541 caagtcatag ttgaaggact ggacagacgt tagaccgtgg gcgccccctg aatagatata 3477601 attgagtgtt tgaatgctga gcttgcctgc cgcattgtat ttgacgctga aggatgtttg 3477661 atattcccgt tttaaagccc tgctgttcgc ctgctttttt gtttttcagg tattcctgat 3477721 acgattgttc atgtaggctt tcagctcttg attgattttc ttttcaaacg cggcattccc 3477781 gacgtgatgc acttgtggat acgttaactc cttgatcttt ttgtacgtat gggtgctgac 3477841 agtcggtgtt ttcgcttgaa ctgcttttaa agatggggcc gcatatgcaa atacagaaaa 3477901 aagcaagact gcaatgcccg cggctttcag catgttattc catttcatac aatctactcc 3477961 tttgatgtcg ttgtttatca ttcccttatt taagcaatac acacttttat agactgatta 3478021 aatcgaaaga agtttctagg tctaacagca tgatttttcc aataaaaaaa gagacacagg 3478081 atgtctcttt ttttactgtt tgcgcccaga aatcgcttca tgaagggctt gtgccaaatc 3478141 tgtatttccg aacatctcta ataccgcaat gacagtctgg tccggaatgt gctctgcttc 3478201 gtgttttggc acgaccagat cgtccatggt ttttttcaag ctttcattca gcttttgctg 3478261 cggatacgct ttggcgtaca gctccatcgg atcaagatca tggttcacgc accactgggc 3478321 aaacaccaaa atcatcatat tttcatcgcg ttcgtaagct tcagtgagct gtttttcgtt 3478381 catttgtcat gctccttatg aaaagtatct tccttaaaga tacaggagcc gatcaaattc 3478441 gtctatccca atggcgatga gcagcaaccg catcgataaa tgccttgctg aaagcggtgt 3478501 agtcaggttc atctttagcc gttacgatgc ctagcccctc tgttgtcccg acagaggatt 3478561 gaagaaggtc aattccttca tttgccgcac cgatcgcctt gtagtgattg taagcttctc 3478621 tgataaacgc catcgcttgt ttgttgtctt ttaactccag tcctcctgcg gcatagacgg 3478681 catcatacag aacagaatca accgtcagga acgtgccgct ggcctcaagc tgctgtccgc 3478741 tgccgcttgt catatacccc agattttgac tgatgatatc cactgtgatt ccttcttgct 3478801 ttaaggcttc cagtactgtt tgcagctctt tttcatgaaa tccgtttccg gcgagtacag 3478861 cgacttttct tgttgacgcg gttttcactg tacgggcttg gcttaacgca ggcgaagtaa 3478921 gaatttcttt agatgcttta cgcttcgcgg gcgccgccac gcctactcct ttggcgattt 3478981 cttctgctaa atctgcatcg acattgctga agacatcaac gacctgccgc tgtacgtctt 3479041 tgcttttgac cttcccgacc tcgaagcaga aagcagaaat gatgtgctgt ttctccacag 3479101 gagacatgct gttccagaaa agcttcgcct gtgagtaata atcgttgaag ctgtcgcttc 3479161 gctggcggat ttttttgccc tcgacttttt cctgatagtg gacgtagccg ccttcttcag 3479221 ctgtcgcagg cgacggatca ttgttttgca gtgagttttt atgataagcg acaggtccct 3479281 tattgatcgt catccggtga tagccgtcgt attggttgtt atggaatgga cagaccggcc 3479341 ggttaatcgg aatctcatgg aagttcgggc cgccaagacg gatgagctgt gtatccgtat 3479401 aagagaaaag ccgcccctgc aatagcgggt cattggtaaa atcgatgccc ggcacgacat 3479461 ttcccgggtg gaatgcgact tgttctgttt ccgcaaacac attatcctga ttgcggttca 3479521 gcgtcatttt tccaatgatc ttcaccggca caagctcttc cggccacagc ttagttgggt 3479581 caagaatatc aaaatcaaac ttgaattcat cttcctcatc aatcatctgc acgccgagct 3479641 cgtattcaac cttgccgccg ttttcaattg tttcccacag gtcacggcgg tggaaatctg 3479701 gatctttccc ggcaattttt tgcgcttcat cccatacgag agaatgcacg ccgagcaccg 3479761 gcttccagtg aaatttcacg aaacgtgcct ttccttgttc attgacaaaa cggaacgtgt 3479821 gaacgccgaa gccttccatc attctgtagc tgcgcgggat gcctctgtca gacatcgtcc 3479881 acatcaccat gtgggcagac tcagggttat tggcgacaaa atcccaaaat gtatcgtgag 3479941 cagtcgcagc ctgaggcatt tcattgtgtg gctcaggctt aaacgcgtga accaaatccg 3480001 gaaatttgat tgcgtcctga atgaaaaaca ccggaatgtt atttcccaca aggtcatagt 3480061 ttccttcttc agtataaaat tttgtcgcaa agcctctggc atcccgcacc gtgtctgcgg 3480121 agcctttaga acccgcaacc gtagaaaaac ggacaaatac cggtgtcttc accgaagggt 3480181 cctgaagaaa tttggcccgt gtgtattccg tcattggttc gtaaacctga aaaaagccat 3480241 gcacgccaaa tccgcgcgca tgcacaacgc gctccggaat cctctcatgg tcaaagtgcg 3480301 tcattttctc ccggaaatga aaatcctcca tcagcgtcgg gccgcgaacc ccggctttta 3480361 acgagtgctc atcctctgac actcgcaagc cttggtttgt cgtcattttc ttcccgctgt 3480421 tatcggtcct gtactgctca agctgctcgt cctttgagtg ttcatttaca cgtttgtttt 3480481 ggtcatcact catgtctgct cccccttttt aaaacgaaac attctacagc acatttaccc 3480541 gtggcgttct tcatataaac tgctaatccg ctcattagga tttttggtct acatataaat 3480601 atgcggtcat acacatttga aataagcctt cttcacagaa agaaaggatg gaagcgctta 3480661 ccaaaaaagc tgttgaatag gggaggtcat atcatgcttg ccatactcgg ttttgtgatg 3480721 atgattgtct ttatgtacct tattatgtct aaccggcttt ccgctcttat tgctttgatt 3480781 gtcgttccta ttgtgtttgc cctgatcagc ggatttggca aagatctcgg cgagatgatg 3480841 attcagggcg ttacagacct cgcccctacc ggtatcatgc tgttattcgc catcctgtat 3480901 ttcggcatta tgattgactc aggcctgttt gatcctctca ttgccaaaat cttatcgttt 3480961 gtcaaaggag atccgttaaa aatcgccgta ggcacagcgg ttctgaccat gaccatttcg 3481021 ctggacggag atgggacaac aacctatatg attaccattg cagcgatgct gcctctctac 3481081 aaacggctcg gcatgaaccg tttggtgtta gcgggaatag cgatgcttgg ttcgggggtt 3481141 atgaatatta tcccgtgggg cgggccgact gcgagggttt tggcttcctt aaaattggac 3481201 acgtcagagg tctttacacc gctgattccc gctatgatcg ccggcattct ctgggtgatc 3481261 gccgttgctt atatcctcgg aaagaaagag cggaagcggc tcggcgtcat ttcgattgat 3481321 cacgcaccgt cttccgaccc ggaggccgca ccgctcaagc gtcccgctct tcaatggttt 3481381 aacctgctgc tgactgtcgc tctgatggcc gcactgatca ccagcctgct gccgctccct 3481441 gttcttttta tgactgcgtt cgccgttgcc ttgatggtta actatccaaa tgtcaaagag 3481501 cagcagaaac gaatctcggc gcatgcgggt aatgcgttaa acgttgtctc aatggtgttt 3481561 gctgcgggca tattcacagg cattctctcc ggcacaaaaa tggtggatgc catggcgcat 3481621 tctctcgttt cactcatccc tgatgccatg ggcccgcacc tgccgttgat cactgcgatc 3481681 gtcagcatgc ccttcacctt tttcatgtcg aatgacgcct tttacttcgg tgtccttccc 3481741 atcatcgccg aagccgcttc cgcttacgga atagacgccg ctgaaatcgg gagggcctcc 3481801 ttgctggggc agcctgtgca tctgctcagc ccgcttgtgc cttccaccta tctattggta 3481861 ggaatggcag gcgtcagctt tggcgaccat caaaaattca ctattaaatg ggccgtggga 3481921 acaacgattg tgatgaccat tgcggcgctt ttgattggga ttatttcttt ctaaatgtat 3481981 gagcttgatc gtagcattga gtgagtacgt gatttacaga ggggagaaga tcaaatagga 3482041 tattatgagt gaatagaaga ttcatgccaa caacttctca ttacaatcat aagagcctgc 3482101 tatattgcag caggctcttt cacatttggc attatttttt tgtatagcgc acccagtcat 3482161 aatgagcgta tagcggattt acaccattgt aggagccaag ccattcatcg acacccgtgc 3482221 cattccacaa gttcatcatg atctttccag gtgttgtcgg aatttggttt gttgcagtat 3482281 gttttaattg cccgtcgaca taccatttaa tagagtttgg ctgccaatcg aatgcatacg 3482341 tatgataggc attggctgca tcaaacccga gatcaacaat cttctcatgg tttcctgcac 3482401 catttgtata atagttaaat tgaaccttcg ttgtgtcttt tcctaaaaat tcgatatcaa 3482461 tctcatccca aggagttcca tctgttggac ctgtgtaagt gaagaacgat gaaacgatcc 3482521 ctgtgttttt agctggtttc attctgactt cataaagtcc atagccatat gtttgaacag 3482581 aacggttttc cccgcagtca aacttgttat aagctgggct tgttagcgct aaacgcattt 3482641 cacccaatga cgtcattgat acgttattag cccgccacgt gcagttgaac atatttccat 3482701 tcgaataacc atctgctttt tgccaaaaac cggagttata gccgttaaaa gggtcaaaaa 3482761 acgatccacc tgtttgagct gaggcagtag cagtgactgc aaacaaactc ataaacaatc 3482821 cagtgacaag aagcagcaac actcgtttca gataaggcat attggcattc ccctttcatt 3482881 gaaagcgttt tctatgttga tcttacatga ttcttttaaa agggaacatc ggtcaaaata 3482941 atgataatat cgaatcttac taacttgaat cctgtaacta tcatcatctt ccctctgaaa 3483001 aaaataaaaa cctaaattac catcagcaca gacagagatg atccgcactc attgcaattt 3483061 aggttttgcc tgctttatca gtaacaatcc taccattttc atatgtgaat gtaagaaaaa 3483121 gtgaacacaa ggaaacacaa atgtcagcgc tctcattatg cttgtttaac taccctttct 3483181 atgtgaatgg ttaaatacag cagctcgtca cttgtgagct tgtgctcata ctcccgctca 3483241 atgtaggttt ggattttctt cgtgcattca tacgcgcgat gatacttttc tttcactgta 3483301 tccagcaaaa aatcgtcctg gctttccatg tgagtgccgt taaatagacg ctgcgcgaaa 3483361 aactttaagt gggtgacgaa ccgataatag tgaagcgatt cttcgttgaa ttcaatctta 3483421 aaatggtatt ttacaatact caaaatctct tgcatgactt ttgtaatgtt gataatattg 3483481 ggcatctctt cattcagctc ggcatttaca atatgcagag caataaagcc tgcttcatcc 3483541 tctggcagag acacaccagt cttgtttttt accataacca acgcttcttt gccgatcgca 3483601 aattcgtctt tgtagagccg ttttgtttcc cacagcaagg cgtttttgat atcaagccct 3483661 ttctggttgc gctggatggc aaagttaata tggtcggtca gcgacacata gatgctgtcg 3483721 ttgagctttt tgccgagctg taattttgcg tagctgataa tctcttcgga tacttccata 3483781 cactcgatcg gtatatcata caaaagggtt ttgaactttt ctgatacatc cttgttatcg 3483841 agcgtgaaca ctttctcaat gcgggcttca tcgacatcat cgccggactt tttctgaaac 3483901 gcgagccccc tgcccatgac gaccaattct ttcccctgtt cattgaccac gctgatcaca 3483961 ttattgttga tcaccttcgc aattttcatg gcatgtccct ccaaatctac taagaacaga 3484021 ctatatcttg attgtacatt ctttttgtac taggtcaata tcatcaggga aagacggaag 3484081 ctggtcagta caattcactc cgtacctgct gcccgggctg tttttgaagc agcgcctcca 3484141 gatggcgttc aaatgatgcc ttgtcagctt tctgcttttt gacaatgctg ttcatgattt 3484201 taatgctttc agcactgtat tgtgtatatt gttttttcag ctgatccagc tgctgtcttg 3484261 tcttcttcgc gtttttcggt gtgacttggt tgatgagttt gatcatactg tctgcggtct 3484321 caaaaaaacc ggctctattt tctgtcagct gctgaatttc gatgcggctc atatcttgat 3484381 tacgcgtttt ttgaagcaag gcaaccgcct cgctgttttg ttttttgagc gatttgttct 3484441 caagcttaat cgattcgaga ttctccttcg caatgtctgc ttcttcttca gtcatgctga 3484501 ttcgcacgaa gtattctgga ttgccgattc cataatcaaa tgcttcgctc acttgtatca 3484561 tggaactgaa cacaatggcc agctgcctgt cgcttgcgag ggcttggaaa tcctgctttt 3484621 tcttactgct catcggtttg gctgcggttt gttttactgt cttttgatca cagtctgcga 3484681 acatctgagc ctcaccttca ctttcgcatg cgctcatcac aagaactgtg accagcaggc 3484741 ttatacacaa gcctattcgc ctcatgctct gtctcctctc tgctgaatcc cttctggaaa 3484801 ataccataaa atatagttaa atggtaccag atgcacctaa ccccagcaat aaatcaaaag 3484861 tatgatttga agcgaaaaaa cataaatatt ttgtaaaaat tgacgtgcat tccattcttt 3484921 tcaggcccat ttctcgtaca atagaagtat cgttaccgga gaggggctct gatgatgaaa 3484981 cgttttacga aacaagaaaa cagctgggtg ttatatgact gggcaaattc agcttactca 3485041 attgtcgtga ccaccgcggt atttccgtta ttttataaat cagcagctgc ggaaagcggt 3485101 gtcagcgccg ctcaatcgac tgcctatctg ggctatacca ttgcgatttc aacgtttatt 3485161 cttgcgatgc tcggccctat tttaggcaca atcgccgact atgaagggtg caagaaaaag 3485221 ttcttcggtt tctttgtgtc agccggtgtc gccagcaccg cgatgctcgc ctttatccct 3485281 agtgaacatt ggctgctatt gttgctgttt tatacggtat cggctatcgg tttttccggc 3485341 gccaatgtgt tttatgatgc ctttctcgtg gacgtcacgc ctgagaagcg gatgaatctc 3485401 gtctcggcac ggggttttgg cttaggatac attggaagca cgattccatt tatcatcagt 3485461 attgctgtca tcctgctcgc acaagcagag actattccag tgtctgtatc ggccgcaagc 3485521 cagctgtcct tcttcataac ggctgcctgg tgggggctgt tcaccatccc aatgattaaa 3485581 catgtccatc aacgctatta catcaaaaaa gaacctcata ttgtcatcaa cagctttaag 3485641 cggctcggcc aaacgatgaa acggatcagg caataccggg cacttttcct cttcttgctc 3485701 gcttatttct tttatatcga cggagtcggc acgattatta cgatgtcgac atcctatgga 3485761 tcagatttag ggatcggctc ctcaagcctt ctgatcatcc tatttgtcac ccaggtagtc 3485821 gccgcgccgt tttcgattat atacggaaaa ctggcagaac gcttcacggg gaagaccatg 3485881 ctgtacgtcg ggatcgtcat ttatatgatc gtctgcgtgt atgcctattt tatggagaca 3485941 acgcttgatt tctggatact ggctatgctt gtcgccacct cgcaaggcgg tattcaagcc 3486001 ctaagccgtt cctatttcgc caagcttgtg ccaaagcgcc acgccaatga attctttggc 3486061 ttctacaaca tttttggaaa attcgcctca attatggggc cgctgctcat tgccgttacc 3486121 gcccagctga ccggtaaatc ctcgactgcg gtgttcagcc tgatcatttt gtttgtgatt 3486181 ggtattgtga ttcttgcctt tgttcccgag gaaaccagca cagatgtcag ccagcagcaa 3486241 aatgacctgc ccctttaact gggagcaggt cattcatcat ttattcgctt tattcacctt 3486301 cagctgtttc cctttgacgg ttgtgttctt catcactttg agaacatgag ggcctttacc 3486361 atttaaaatc tcaacgtatg aggcgttatc catgatcgtg atgatgccga tgtcgtcagc 3486421 tgacacaccg tcaattttgg caatcgttcc tacaaaatca acggctctga ttttcttttt 3486481 ctttccgccg ttaaaataca gcttcataat gtctttattc agctcttcgc ttttgtcctt 3486541 tttgctttcc ggacggtcat tcagtttagc tagaaattct ggtttcttcc ttgccacttc 3486601 ctcttgagaa ggtgcttcta ttttttggat ttcaaatccg atatattctt caatgtcggc 3486661 taaaaaccgt ttttcgaagg ccgtgacaaa cgaaatggcc tttcctttgt tccctgcgcg 3486721 tcccgttcgg cccgtgcggt ggacatagct ttctttttca agcggcagat catagttgat 3486781 gacaagggag atattttcaa tatcaatccc gcgcgcggcg acatccgtcg ccactaagta 3486841 acggtactcg ccacgtttaa attcattcat gacgtcgaat cggtcttcct gaatcattcc 3486901 gccgtgaatt ttatcgcatg gatatcccaa gtcatccaat tcatcggtca gctgattgac 3486961 gtgctccttc gttcggcaga aaatgatgca gctgtcggga ttctccgtca tcagcacatc 3487021 tttcagcaat gaaaacttat tctcttctct tacttgaatc accgcatgtt caatatttct 3487081 tgtggttagg ccggccgctt tgacctcgat atgctcgggg ttttgcatat attgacggct 3487141 cagcttctcg atatcctgcg gaagcgtcgc tgaaaacagc atcgtcgtac gctcagtcgg 3487201 cagatgcttg ataatcgcct ccacctgctc aatgaagccc atattcagca tctcatccgc 3487261 ttcatcaatg accaaataag agagacgatc caacggcagc gtgccttttt cgatatgatc 3487321 cagaacacgt cccggcgtgc cgacaacaat gtggcttttt tgcttaagct cagctttttg 3487381 tttatcaaag gaggattttc caaatacggc tgtcgctttg atccgtttaa atcgtccgat 3487441 gttcgtgata tcttccttta cttgcaccgc aagctcacgg gtcggtgtta aaataagcgc 3487501 ctgcggcttg ttttcatccc aattcgccag ctcacagaga ggaatcccga acgaagccgt 3487561 tttcccgctt cctgtctgtg atttgacgac aagatccttt cgttcaaggg cagcggggat 3487621 cacactctgc tgcaccttgg tcggttctgt atatcccagt ccttccaatg ctcgtaaaat 3487681 gtcatgactg atttgatagt ttttaaaatg actcatgtat aaactcctgt ctcttgcaga 3487741 tgttctcatt atactctaat tgaccaaggc atatgtgttt tgtcgaaaaa tgatgtatta 3487801 aaagccagcg attccctggc gttttagctc ctgaacagcc aatcgcgcca gtgcgtcggc 3487861 ccccgcgcga ttcgggtgca gcgtatctcc atccatataa agcccgagtg ttctttccgg 3487921 accgatcgat gtaaagtatg ccgagctgag gacatttaag tcaatgagat atgttttttc 3487981 ctcttcggcc aaagctaaaa tagaggccct gtaccatctg tttacagacg aatggatgcc 3488041 ttcagaagta aaatcggttg cccggccctg aggcgttgat aggatgacgt ccgctccttt 3488101 cgcttttacc tgacgaatca tatcacgcat cacctcttta aactccgctt cagattcttt 3488161 atgcttcgga tttgtgtcat taatgccaag ctgcaacata aaataatctc cgggtttaat 3488221 atacttcaga atcgcctcaa gctgtccatc atttctgaac cctctcgcga tctgcccgcc 3488281 agacgccatg tttctcactt gaaaggtgtg tttatcgata tagtgaggca gcatctgccc 3488341 ccagcccgcc tgcttgctgc tgttgagcgg ataataattg cacaccgtcg agtcgccgcc 3488401 gacataaatg gttcgattcg ttaccggctg atcagacaat ttctttattt tcaaggcgct 3488461 gagcgtaaaa gcggtgcctg cctttccctc tgtcaccagc agattcagct gcccgtcggt 3488521 gacgggaatt tggaacgtat cctccgcgcc atcccctgtc atattgatga cctgaaacac 3488581 gccctccgct gccacactgg cccttgccgt attgccaagc gtcaccttca cctcataaag 3488641 gccattcggg agatcaacat taaacgtgtt attgcttttc gtcccatacg ctaaaaactg 3488701 aaccgcatca ctcttcacac cagccccgga tgccgccaca tccctcatat tctccggtgt 3488761 ttgaaaaccg tagccctttg accggtcata ccgatcagac gccctgacac caatataacc 3488821 aggctccatc gaaccgcttc caaagtcaaa ctgatacacc ttcggctccg ccgccttcac 3488881 attctcaatc ccgccaaaac acagcatcag catcatcaca aaaaccgctg ccatccattt 3488941 tttcatcaag actccccctc tatgaaaacg aatacattaa tgcatactcg gtgattgttt 3489001 ctttatgatg actgaattaa gaaaaaaatt gcgttgagga ataaaaatga ggggagagtc 3489061 tcaagaaggg gaaaatcagt gtgacttctt gtcacacttg atcacatccc aacctccgca 3489121 atagaagctt atttggtttt cttcgtcata cacataataa cggagtcttt cccattgatc 3489181 gtcagtcggt acaatctcca atgcaaccga atcgatggat tcaaggtcat ccagctttga 3489241 tgcactaatg ttttcaaacc gcaattgaat gtcacaggtt tgagcagatc gttttcattc 3489301 aaacacagga atatgaatat aacgatcatc ttctttcata tagaaagaaa actcgtttaa 3489361 tgtaaatgga cctgtatcct catcagaaag atgctgtttc aatttctcgt attgtgtgat 3489421 attcaaatga attccctcta tttatatgat tcaccgccaa tcatataaat gtccacagca 3489481 tcgtattcaa accatatgat ccgttcgcct gagtccgtta ggcattggag cttcccttct 3489541 gaaaaatagc ttttatccgg ttgaggatca gtgatcagaa aaacatcatc attgatggaa 3489601 gctagcagaa agagaaaatc tgcaatatcc cggtctgctt cctgtaatat ggattggaaa 3489661 tggaattccc ttttggccag cttcgtcacc ttgtaagcat gaccttcaaa atactcggac 3489721 aggtcttcta taaatgaacc agtcgttatt acctgtatca tgattcgatc gtaggcaagc 3489781 cctgcccaaa aacgataaaa cgactctgca tcttcaagtt cgcatgccat aacggtttgg 3489841 tcaggcttaa gctcgatcat gtccaaattg ccaatactgc ttatagaggt tatttccata 3489901 aaatcttccc cttatcagtt ggatagcgca acgcaaatct cttgtctgac ttgttcatac 3489961 aagagaatgt gatgatacag atccttatcg tttttgatca tatccggaag tatgtcagga 3490021 tacagctcaa aaaagctttt ctccaacgaa cgccgctgat gccggggtat ccttttattc 3490081 gccagcacat aatccaaact gccagcaaca agcataaaaa actcatagat ttccgcttca 3490141 aagccgtaca attcatcagg gtactgcttt tcttcaagct ctcgctgtct ttttctcagt 3490201 ttttgaagca cgttgatcct ctcccttccg caataatctc atttatttcg aaacagaata 3490261 ggcggatcat tatctatcgc ctccaacagc tcttcaccaa acacagtgat tgcacatttc 3490321 cacgggtctc ccaaaagtcc ccaggagaag tcctgatgaa aaaagaaata atagtctcca 3490381 tttggaaata cgggaacagg ccattcgcca aattcatcct taggcattgc ctgatgagga 3490441 ctaaaggtat atccgtcatg ctgccaatct agtgcgtaca ttacatcgtt ctttccagta 3490501 cctaattgaa atgcttttaa aatagaagtc tctaaatcac ttagcactcc gctcacatca 3490561 ttatgaccag ctttactgct catcgcgctt gagatatcaa acactcgata tggatcaggc 3490621 gggatgatgt gatgacatct gcttccgggc ttccatttta tgatcttgtt cacttctgac 3490681 cagatgcggt cttgttttgt ctgacttaaa gcgcgccaat tcatcataat ctcatcccta 3490741 caccttattg gatatcctgc ttataaacac cagaagaggc cactgcgtaa acagcgtaac 3490801 ttgtcagttt cagctgttga acatctaggc cttcaccgtt cgaatcacag catgttatct 3490861 cttccatctc ttgactcaca tcggcagaaa tcaaataaag agacgactta aggtctgcac 3490921 tgtaacaatt gaacgtccca accaaaaaac cttcttcgga tatcgcgagc tgatcaaatg 3490981 cttctgagtc cggctcttta tccgacagaa tccacacccg tctcacgacc gtttcatcaa 3491041 atgcggcaat gactgcatct ccgtaataca gcatataaat caagccgttt ttttctgcaa 3491101 gtccataaca atcatctaca gcaggcgcat ccatttcttc aagctttcta tcaatgtgta 3491161 tttccttctg ctgaccatct aacgtaaaac accacacact atggccgttg ggattctcat 3491221 catgataaat cccttcatca cataaaccga cccaaagctg ttgtttctaa tccaaaagac 3491281 agcaggaaac ccctgaaggc aagtgaaaaa cacttttcac ccttccctct tctgaaaaaa 3491341 cctttacctt cggctcgtac gattcgtaat aaacgaagac atagccatct gcacattgtt 3491401 gaaagagcag aatatcactg tatgaaatct gctctttcac tctaaaatcc cgaacatcac 3491461 cggaaggatc atagattgta atggtgatac cacctttcaa cccttttcca atgtagacac 3491521 gcccctgtgg atcagcatgg aaaaaacaat cttgggtgtt ctcgttgatg attttattca 3491581 attttaattt tttcattggt tatgctccta ggttcgaaat gaaatgataa gaataaacca 3491641 tttattagct attagtaacg gacaacctag tttcattaat cgttttggga taaatctact 3491701 ttccaattca gccttaaatc atttagtgtt taattggtat gcataaaacg attgatcatc 3491761 aaagcgaact gtttcagctt ctatagcaat cagcattctg ttcatgtcaa taagaaagtt 3491821 agcatttgat tgatactccg gaattataga atttgataga ttcccgattc cttctggatg 3491881 ataactcatc tcaaatactt gccaattgta ttcttccgga tctatttttt ccaatctcat 3491941 gtcgccaaca tctgcactat aataagcgga tgccacattt tgaaatgaaa ttttatgcgt 3492001 atattcacct tcatcttcaa aaaccttaat atcaagtgag agttcttttt taaacacatt 3492061 aaaatctaaa tgaaggacac tgcacccctt atctatataa tcaacccatt cattaatcgt 3492121 ttgatacatt gtcatcccct gcctcttttt aaacaataac gccttgccac caagcagaaa 3492181 acaaattact ccgtatattg tttgatccaa tcatttaaat catctgttga atgcaaataa 3492241 gtttctgatg aatctttcaa atcaatccca cttagaagga ttaacatatc ccagactcta 3492301 tcgtcttcta cttcggggtc atccgcataa acataagttc cagcccaatc cgacacttct 3492361 tctcttgttg tttgtccatt taagacactt ttgattttat ttatgcattc tattagattt 3492421 gtctcgctca atttgatcac cacgtattca agtactaaat gattttttat tagtatgcaa 3492481 agcaccgtac tgatatttag atattgaagc tttttccgta aaagatatgt tccaaaaggt 3492541 ttccaatcta ccaataaaca agctcacatc cgtattccgt gtgcaatata cataaaccaa 3492601 actggcactt aggctcaacc aaaataaaac tatgattgag aatcccttca tcgaactcaa 3492661 tacactccaa taagcagtca aggtgctcga gacattttcc aaaagaacaa actaacgcac 3492721 caatttcgct gctgtattga tgaaacagca gaacgtcccg gtcatcgtaa gcaacatatg 3492781 actgagatat tttccagatc agctgtttcg cttccgtttt ttcgagggca tcaacctcac 3492841 gggtgttggc tggtattgaa tttgataaaa ccagctcaag caattgcctg ctttgcgcca 3492901 gatcagcaaa acgataagtg aagcctcttt ctgcacaagg gactagtttt tctttgattt 3492961 cgctcatcaa taaacgtctt ttattctcgg cgagtttttc gatcaatctt ttttgcatga 3493021 gccgcattcc ctccgctgtc aatttctcaa cttcttttaa attgattcat cattctcttg 3493081 ttttcgttgt cgttcatgtt tagatttgtt ctaaaaaagc ttgtatcgct tatcgataca 3493141 agctttatct tcaactgctt aaaactcacc cagtgggctt ttcacaaaac gctgggaacc 3493201 tttttggcaa atcctcttca tcccaatcaa ttctatattt ttagattctt ttgtcataca 3493261 aataagagag gatggtaaca tctcttattt aatgttccat caataaatgc cccattttta 3493321 tccaatgcag aaattattta taattaagga agtttagaag gattttttgt attttcaaga 3493381 tttaatttta aagcggtcac aaaagactct agcttttctt cattacaatt aatttcgaac 3493441 aagttggagt tcgacttact ttctttataa tcatcaaata taattttaat cttaattctg 3493501 taatttccgt tttcttgatc aatactaaga aataagaatg gttcaatagt ctctaaactg 3493561 atactgtctt gatttccttt tatcatagtt tcgatcccag atatcaacac cttatattca 3493621 ctttctaata aaacagcaga aaaatcgcga acgacggctt tcttattttc caacaattca 3493681 aatacagata aaataaatgg atcatcgtcc aactcttgat accttctcgg tgttaattca 3493741 agttctatac aatcatcttt tattttggcc atatttcctc ctcatttaaa gtttaagtga 3493801 gggtagttgt catccccccc tcgcttaacc ttattaacgc cttctcttag atttatttcc 3493861 ttttccgtgt gtatggaata cgtgtttaga acccttagct cttgaacttc cataagctgt 3493921 gattacttta ccccttttat ttaaaacaac tgtagctttt tttccaacat atttcgttgc 3493981 cccattaggt tgttttatta cttttttagg gcttcgcaca gcattcagtt tggcccttaa 3494041 attgactcca cggcctccat ttcttcctat agattgatta agtccatgtc ttgtatgacc 3494101 tgtgatttta actgccttct tcgtaaactt ataggcgcga ctagcaccct taaatatctt 3494161 cccaggacca aaattagaag cagctgccca agcagcacct ttccatcctt tacctgattt 3494221 atatgcctta tatccatcat aggctgcaaa tccggcattt accacaagcc atacccaatg 3494281 cccgtccgga tcaacattca tcactgggtt attatttcca taagcatacc cattctgatc 3494341 caatgaatct ccgtcgctgc ccgggtctgg gtcgagcgat aggaacacgc cgtttcttgg 3494401 ctcgtagtag cgggccatga gatagtacag gccggtttct tcgtcgtatt ggtagcctgc 3494461 gtagcggtag cgattgtctt ttacttcgtc gcttgcttcg gtttttgttg gatttcccca 3494521 tgcgtcgtat tgatacttgg caacggtttt tccagtgctg tctgagatcg cgatgatgtc 3494581 gccgtgagcg ttgtagtgat agaaatattt cttaccattt tctgtgtagg ataacagctg 3494641 gccgctgtct ccgtacgtgt atgattttgt gacgttgttg tccgcgtctg tttcatacaa 3494701 gacgttcaag ctgtctccgt cgtagaagta gttcgtgact tttccgttga cggttttttg 3494761 gattctgttt cctttttcgt catacttata tgttgcgaat ggcttgtctt cgcctttttt 3494821 ggtaacggcg gtcaggttat cttctgcatc ccacgtatat gtgaatttgc cgtcggatgt 3494881 gcggttgccg tttttatcgt aagagatgct ttcatcattg acttttgtca gctggttcat 3494941 gatgttgaag gaagcgttca ccgttttgct tgagccgtct tttatagttg taacggtttt 3495001 ccggtttccg aatccatcat atgtgtattc aataacagta ccgtcttcat gggtttcttt 3495061 gacaagctga ttcagcttcc catactcata ttgcaccttg ccgcttgctg agctgtttat 3495121 cgttgtgcgg ttgccgttgg catcatattc atagctttcc gtcagaatgt ctccgccgtt 3495181 tttgtcaccg atatgcagcg agcttacaag gtttctttcg tcatatgaaa aacttgttcc 3495241 gccgccgttg cccgtaataa aggtttggac gtttccattt tcatcataat caaatgaata 3495301 tgaggatgta ctgtctttca tctcaatcat ttgatccagc ttgttatacg taaattgatt 3495361 cgttcctttt tggtccccat gaatccacga gaaggttttc agcttatcgg agtcactagg 3495421 atatgtccaa gtttggctgc cgccgcggtc tgtcagttcg gttaaacggt ttttgttgtc 3495481 aaatgtccgt ttctttgtgg tgttctgctc tttattgacg accgacgttt catttccatt 3495541 tttgtcatac gtgaaaatgt acttttctgt accgttatac gactttgatt tcacccggtc 3495601 tgttccatca taagaaagag acacttcgtt gccatttggt gaaatggttt tggtcaggtt 3495661 gctgttggca tcatattcgc ttgctaacac attgccgaga gggtcagttg ttttgacaag 3495721 cttgcccatg acatcatatt cgaatttata ggtttgatct gctcctgccc ggatggtttt 3495781 gcttacctca ttgccttcct tatcatagct gtgaaggata gacgtgccgt tagagagcgt 3495841 catgtttgtc aattggtctg cctgatcata cgtataggtt gttttttcac cttttgcatc 3495901 tgtttcagac gttttcttac cagtttcatc gtaatcagtt gaagtggcgt aacctagttc 3495961 gtcctcttcc ttggtcacat agttgccatt actgtcatac gtgcttttag tcagaaggct 3496021 tccttcaatc aaacggatat catcaaacca gactgtgcct gtcgcactct tttggaacag 3496081 aatactgata tcgactttat tgatcggctt tgttttaggg atgacgacag ctgctcggtt 3496141 ccattcctgt gttccagaag ggaatttcgc attgtagatg cctgtgctgc cgtcagcgta 3496201 agtgacattc gcctgcagag aatagtcttt ttcatctgta aatttgacgc tgcttgcttt 3496261 cgacattcct gtcagtgtga gataaaccgg tttgtcattt gcgctttgcc ctaagacaac 3496321 ggtttgtttt gttactgatc cggcttggga cgcactggtc cgggcagctt ttaatgatac 3496381 atcatcatta aagccttctt cagaatcaac ggatgctccg cttacattcc agttttccgt 3496441 tgctgatgtg aagctgctgt tttgaactgg gttatagctt gatgatactt cgcctttttc 3496501 cagctggact tcatcaaacc atgcttttcc tttgccatct ttatctttat gatcgacttc 3496561 catatacaca acagctttgc ctgcattcgc tggagtcgta aaagtgattt gccgttttgt 3496621 ccagtcattt tttccggcta atgcactgta ttcattgtga atccattgaa ttcgtttttg 3496681 atctttgtct cgcaaatcaa tgttaaaata ggctcttgat ttcgcaagat ctgttttgat 3496741 tttcccgctt aatgtatagg ttgtattcgg ctccagctca actgtttgtg ttgctgacga 3496801 atacccatga tctgttccgg cagacgttga ttggctcaag acctccaatg cctttgatcc 3496861 ggaaagaact ccgcttttat cggcgatgac tgaaattttg ccgctgtctt tagaggcagt 3496921 cagattccag ccggattttt gagcttcaaa gcttccatct ttcaaaatat tagttgaagc 3496981 tgataaatct ttgctcgatt gaatctggtt tccatattta tcataaacag ctgctgacga 3497041 tgattttccg ctctgatcgg tttcggatac agcatccagt ccgtcataag caatatccgt 3497101 gacattgccc tcggtatcct tcatctttgt gacatcgttg tttttgttgt attcgtatgt 3497161 ctcagttcca tatgcatctt taaccgacgt aacgttgcca tctttgtcat attgatagct 3497221 ttccgttgct tttccggtgc cgacgtcatt tggatctaca tcttctacaa cattgttgcc 3497281 ttcatacttt gtattcgttg taatttttaa cccttccgca tcatcaatga cctgaatcgg 3497341 atttcccgct tcattatagc catactgtac tttccggcca tttggctgtg tcatgagaag 3497401 cgtcttttta tcagcatcat agctgtagac atatgtttct tttttagcgt tgatcgcttt 3497461 ttcgagacgg tgaccgctat actgatattc ggtaaagaca ggctttgctt cggtactgtt 3497521 agctgaatat tgtttgacaa ggcgcccttc actatcgtag tcatagcttg tgacagtccc 3497581 gtctgtatct gtaaccttct tcagcaaatc attctcatat gagtaggtga ctttcttatt 3497641 cttaggtcct gtgatggacg tcacatggcc gttttcatca taggtaaatg taagcttgcg 3497701 gcctgatgca tctgtaatgg cggtcagttg atttttgtca ttgtaagtat agacagttgc 3497761 attgttatgg ccatccacta ccttttggag tttgccgcct tttttattga aataagcgtt 3497821 ggtttgatcc tttgttttta atatgaactg atcagctgtt tctgttaatt caagatatac 3497881 accggtcggc ggctgatacg tgccatcggc ttttttcgtg aatcgatgtg tcgtagcgtc 3497941 ttcatcgata tacattgccc cgccatccgt tgagatgaca gatgtttctg catcagcata 3498001 ccagccttgt ccaaataagt gatcagagct gtcaagactg ttgtaggttc tcgataagcc 3498061 aagtcccgga ccgcgtccat caattgacaa atcttcttca ttcacaatga cattgcctgt 3498121 cgcaccattt aactggccgc ttgggatatc aatgatagac cagtactctt ctgtacctag 3498181 gaattctgcg ccttcatgga acgttgggtt aaagggcgcc gttggaatcg tttcaccatt 3498241 cgcatcatag gcgacaagcg tgaaagaata attcttcttc cctttgtaat tcccatttgc 3498301 attgttatag acaggtgatg gatcgagggc taattccccg ccttttccat ctgtatgaag 3498361 cttatagctt ccggctttga tttcctcaga agtcggccag atgtttttat tttgggttgt 3498421 ccaatgatca gcatcaccaa catcaaagga ctgatattct ttaccgttgt aaatgttaac 3498481 tttatagccc ttcgcatttt gaaccttttc ccatatcaaa ttcacataac ccgtttgact 3498541 cgattttgta tttgtataca aatagccagt tacattcttt ggcctagcga tatcaggaag 3498601 tgccggggta gcagccgggg atgcaatggc ttcgccgtct ttgttgtatg cgataatttt 3498661 aaacgagtaa tttcttttgg ctccatctcc cccggcgttt ttataggttg gtccgggatt 3498721 gatcggcagc tctgctccgc ttccgtcctt taggtgaaga gcatattttc ccgccttgat 3498781 ttctgcactt gtcggccaga tctttttccc ttttgtggtc caagacgtct gatttccgag 3498841 atcaagtgtc tcaaagcctt tcccattgaa cacctgaacc ttatagccgg ttgcaccgga 3498901 tacagctttc caagaaaggt cgaagtatcc tgtggcattc ccattattgt agccctttgc 3498961 tgacggtgct tgtgcttttc ctacattagg gataacgggc tttgccggtg cggacatcgc 3499021 tccttcacct tggtcaaata tcgcactgac gccaatccaa tagtttttgc ttgtagcata 3499081 gcttccgccg gaattcttat agaccgggga tggatctaat gccaattcag ctccatcctt 3499141 gccgtccaga tgcagtttat atctcttgga ggcaatttct gcgctcgtag gccagatttt 3499201 tttacctttt gtgctccacg acgtgacgtt gcctgcagaa atcgcttgat attccttacc 3499261 attgtaaatc cataccttat atccttttgc gccttcaacc tttttccagc tgatatcgaa 3499321 ataaccagtg gaatcgccgt tgtgataggc tttgattgta ggtgtgtttc cctttggaat 3499381 ggtatacgtc acttcaatat atggtttatt ggcggagttc gctgaagaaa ttagtttttt 3499441 ccaatattcc ttgccgtttc cgtttgtatg aagcttaaat ccatagttgg ccccgccgga 3499501 gttccatgac tttacagcag cggtcacatc ataactcgcc cactgtcctt tatggacgtc 3499561 ggcttttccg atatttttag atgccggttt ggtgttccat gtcacttttg cattatcata 3499621 attgctgttg accgtatcca gccaaaggcc ggttgccttt gttccataat aggaatgggc 3499681 tacgtatgtt tttaatgtag ctttagtgac agtcatattt tgaattggct ttaggttgtt 3499741 aaatttcatg aacgcatagt ttgtgcctgt tgttttgtca taatagcccg ttttcagtac 3499801 ataggccttt aaattagcat cccatttttg tgaggaggcc gaatagttcg tcgtcgggta 3499861 ggcactcatg acaaacgtat ccgatgaaac agataaagaa gttgacgggt cgatagatac 3499921 tggatatacg cgttctgggt ctttcagcca gttctcgtct gccgtaagat gaagcaaata 3499981 cccttcttca ttcttttcca gcttatagct gactttgtct gaccgttcaa cctcgccgga 3500041 aagctcatct agttttgaat ccgtcataaa aggcttaggc acagaaaaaa caacttttcc 3500101 tttttcatca gaaaaatcaa tggatccatc ctcttgttct ttagcctgca aatcggtttt 3500161 taactgaaat gtaaatgtgt tgtatccatt atactgatga aggactaaat cttcttttat 3500221 gttttcattg aatgtgaaag tctgaagatc aatattcgga aacacatccg gatacacaat 3500281 ctcattactg tcagtcttat aatctgctga ggtatctttc ggagtaagtg aagttttatt 3500341 cgggcctttc gcttctgcta gtgaatatgt aaccttatgg tcattatgct caaaagtcgc 3500401 ataaagcccg ttcttcattt gcttttgaaa atctgaattc aaaatagcgt tctctgtctc 3500461 gacttgtttg cttgtcgact cttttaactc aggagaaatg tcttcccagt cggcatccgg 3500521 tgtttccttt gtatgaatag gatcaaggta tacttcctgt ttatagacac cgtcaccttc 3500581 ataatagagt tttgtatttt ctgttctttc agaggtgatc tcaccctctt tgtttatatc 3500641 ttttggatca aaaggtacag cttcctcagt ttgttctttc tgaagagttt cttctggatc 3500701 atcggcagca atacggtttc cattctcttc ttctgtagat tttgctagta catcggctgg 3500761 cactaatgaa atcattaaag ccaacactaa aaatgctgca atgaaccttt taaagtttcg 3500821 cctctttctt tttttcattt cctctctcct tttgtaataa aagtaatatt tactcaataa 3500881 tcttaactag actgaaatat cattacaata tttttctaga aaatttatct tattttaagg 3500941 attagcgaga gtcaattgac ctaaaacaaa aaaaggccgc ataggccttt ttacattttt 3501001 tattgtattt gttcaatatc cgtaccctca gctgtcacat tcgccttccc ctgcctcctg 3501061 acaagcgtca aggccatgcc cgcaaagatc attacgatgc caagcgtttg atagaggtca 3501121 gggcggaagc ctgtgaagac ggtatcgagc acgatcgcga cagcggggtc gagaaataca 3501181 atgattgaaa taaatttcgt tgataaaaat cgtaaactgt caaaaaacag caaatataca 3501241 atacccgtat ggatgatgcc ggtagatacc accataatcc agtttccctg agataggtcc 3501301 gcaaaagcgc caaagtgaat aaacggaatc aggatgataa cccctaaacc tgtctgcaag 3501361 aaggtggtcg tgtaaggact gagattgtga atgccttttc ccaataaagt ggtgaacgca 3501421 taaaacagtg cggcgagaac tgcccatatg atccctgatc ccatcagctg tgtcaatgat 3501481 gtgctgccgt taatcccgga aatcagcgca gtcccaagaa agcagatgat aatggagctg 3501541 acggagatca catttaattt ctctctgtag aagaagctcc ccagaagaag aacaagcacc 3501601 ggcgctagat gataaacaga gatggcaatt gtaacggacg tttcttcaaa agacttaaat 3501661 aagaacaccc agttgaatac aagaaagaaa ccgcacgcca atgtttgcag cacgtctctc 3501721 ttgctccatt tttcagtttt atactggccg gacgccagcc agcaaaagcc taaaaacagc 3501781 gtcgcgcaaa ggcagcggac aaagaccaat tcaaatgacg gcagattggt atgctctgag 3501841 aaaaagccga tggagccgaa aatcaccata gagatgacca ttttgattac ggctgttgat 3501901 ttttgttttg acgatatgga aggatcctgt tgcatcaaac gtattctacc tccaatactg 3501961 catagcataa actgtttttt gtgaattcag aaatctacac atagaattcc tcttttttac 3502021 atgtagatat tataacactt ctattctaaa taaaaaaaag cgcccaaggg cgcttttttt 3502081 acaaatctat cgaacaatca aaaccgggca tgttgataat tgagacactt tatggctgac 3502141 gcttccaagc atcatttctt tcaggccgct gatcccccgg ctgccaacta caatcaggct 3502201 gacgcctttc tcttttgcgt gatttagtat ctcatgcgcc ggctcgccat tcgcgtaaat 3502261 ggtttcagct tgaacgcctt tttcggctgc tttttctttt gcattctcaa ggattttcag 3502321 gccctctttt ttaacctcgt tcctgatttc atcaataaag tgttcaggca catagacaat 3502381 tcccgtcaga gaagaagtcg tgacgacggc ttctctcccc acatgaagaa tgcttagttc 3502441 cgcttgttgc tcttttgcca aatgcactgc ggcatcaagc gcttttgcac tcatgtctga 3502501 tccgtcaatc gctactaaca ttttgttaaa catgctcttc ccgcctttcg gactgtgggt 3502561 ggttcatctt tctcttttat tgtccgcctg catttcgtta ttgtcaattg aagcgcatga 3502621 gttttcaaaa aattgtcaga gactctctcc gtttgtggcg ataacctgct gataccagtt 3502681 gaagcttttt ttcttgatgc ggttaaatgt tccatttcct tcattgtccc ggtctacata 3502741 aatgaagccg tagcgctttt tcatttccgc agtagatgcg ctgacaaggt caattggccc 3502801 ccatgatgtg tatccgatta attcaacgcc gtccgcaatg gcttcgcgcg cttcaattaa 3502861 atgatcacgc agatagttga ttctgtaatc gtcctgaatc gtgccgtcct cttcaacctt 3502921 gtctacagcg ccaaggccgt tttcaacgat gaacagcggc ttctggtaac ggtcgtataa 3502981 ggtgttgagc gtgatgcgca agcctttcgg atcaatctgc cagccccatt ctgatgattt 3503041 gaggtaaggg tttttgactc cgcccagcag gttgccccct gattttgcaa gctcttccgg 3503101 atctgtgctc gccgccatcg acatgtagta gctaaatcca atataatcca ccgtatgttc 3503161 tttcaagagc tcttcatcgc cttcagccat ttcaatttca atattgtttt ctgccagata 3503221 gcgtttcata tatcccgggt atgcgcctct tgcctgaaca tctgagaaga aaagtgtttt 3503281 gcgctcattc tccattgccg cgaagacatc ctccggctta gaagtcatcg gataggttgt 3503341 cgttgccgct atcatacagc cgattttcga atcaggaatg atgtcgtgac ccgctttgac 3503401 agcaagagca ctggccacaa attggtggtg tgccgcctgg tacatcgcgt ttaatttgtt 3503461 ttctccttct tcaaaaacaa gaccgcctcc ggtaaatggc gcatggagca ctacgttaat 3503521 ttcattaaac gtcatccaat acttcacttt gtgttgatag cgtttgaaaa ccgttttggc 3503581 atagcgttca taaaactcta tgactttgcg attcttccag ccgccataat ttttcactaa 3503641 accgagcggc atctcataat gagagatggt tacgacaggc tcaatatgat gctttaacag 3503701 ctcatcaaac agatcatcat aaaatctgag gccttcttca ttgggctcct cttcatcgcc 3503761 attcggaaaa attctcgtcc acgcaatcga tgtgcggaac gccttaaatc ccatttctgc 3503821 aaataaggcg atatcctctt tataacgatg ataaaagtca atcccgttgt gatacagatt 3503881 caaggaagtc attgattcat caaatggaga catgatcccg ttcggcgata cgtcagctgt 3503941 cgaaagcccc ttaccaccct cgttataagc accctccact tggttggcag caactgcgcc 3504001 gccccataaa aatccttctg gaaatcgttt ttcatttgaa ctcatattga tcaccccatt 3504061 agttttttca agataaagca agcagcgctt cttttggctg cactttaccg atctctttca 3504121 ccggcgaaaa cgaatattgg tctgtgttgg tcacaatcac cggggtaatg acgtcatatc 3504181 ccgcggcttt gatttgctcc agatcaaagg acacgagcgg atctcccggt gcgaccttgt 3504241 cgccttcttt gatgtgagcc gtgaaccatt gtccctccag ctttaccgtg tccaatccaa 3504301 tgtgtatgag tatttcagct ccctgatcac tcgtaatgcc aattgcgtgt tttgttttaa 3504361 aaatggtggt aacgcttcca cgaacaggcg aaacaacttc tccttcttca ggctcaatgg 3504421 caaatccttt tcccatgacc ccagcagaaa acactccgtc tttgacttca cttaaggctt 3504481 tcacttctcc cttaatcggg ctgtgaatga tctctctgct gccttcatgc actgccggct 3504541 gctggctgcc gtcagaaggc acatcctcga atccaagcaa atacgcagct gctgttcccg 3504601 ccgcaaacgc aatcacaagg ccgatcatcg cgtaaataaa cgttgggccg ataaagacag 3504661 ggatgctcgg cagacctgca ttccccccga cgatatagga agcaacaccc gtcatgccgt 3504721 aaaacgcgcc accggctgca ccgccaatca aagcggccgc aaacggcttt ttcaatcgca 3504781 tattcacgcc gtacatcgca ggttctgtga tccccatcag cgccgtgatg cttgtggtaa 3504841 gcgcgagtga tttaaatttt ttgtttctag agcgaaggaa gacggcaaat gatgctcccg 3504901 cctgccccat attcgccaaa aacatagccg gcagtaaata atcgtggccg ttttgagcga 3504961 tgttgttgat catgatcggc acaaaggcat agtgcatgcc cgtcataatg attaaagaga 3505021 atgtacccgc cagcaaaatc attgccacaa gccctgcatg atcaaacaaa taattgaccc 3505081 cagaagacaa gtattctcct aaaatagcgc caagcggacc gactgtaatc aatgtcagcg 3505141 gcacgacaat caatagcgtg aatgtcggaa ccacaatcaa tttgagagat gcgtgtgtaa 3505201 aacggtcaat ccatttttcc acgtatgaag caatccaaat cgacagcaaa atcgggatga 3505261 ccgttgacga ataagtggca gcggttacag gaagcccgat aaaggaaatc ggtttccccg 3505321 caccgagcag ggctgtcaaa tccggatgca ggatcgccgc cgcaatggca gccgctacgt 3505381 acggattgct tccgaatttt ctcgccgcac tcatcgctag caggagcggc aggaagtaga 3505441 acgcaccgtc accgacagcc gtcaaaatga catgaacctg gctcttctcc gccatccagc 3505501 caaacgtgac tgccagcgcc acaagtcctt tgatcatccc cgctcccgca atcgcaggca 3505561 gaataggggt aaacacccca gaaatcacat caaagaccgc actcagcaca ttctttttct 3505621 gagaggatga accagcgctc ttttcatcac tgagattgct gtgccgcaca atcgcctgat 3505681 acaccttcgg cacatcgttt ccgataatga tttgaaactg ctcgccgctg atattggtgc 3505741 ccatcactcc aggcagctgc tccagctgac tgcgatccgc cttcgcgttg tcatgaagat 3505801 taaaacgcag cctcgtcatg cagtggatca cgcgctgaac gttttcttca ccgcctacga 3505861 gttgtaatat gtccttcgat aatttatcat aatccatgtg tatacctcct ttttatgggg 3505921 ggactgctgg atgaaaggtg gccgcctttc accagctttt tttgtatcaa atgctgcatc 3505981 acctcctaaa agagaataaa aaaacctaaa tgacacagat tgcgagagtc tcctcctgca 3506041 cctgcaccat ttaggttttg cctgctttcg cagtaacaat cctgacgggt cgttttattt 3506101 gtttgtaggt atactttagc actagattcg tgagatgtca acgctttcat ttttggtgtt 3506161 gactatcgtt tctagaacaa aagtaatcat aaagatttga acttagtatt aacttcaata 3506221 aaaaattatt gtaattaaaa accttgaaag gcattttttc caatcaaggt tatgaatcgt 3506281 taccgtttaa atttttttaa agacttcttt atctgtacta ttacattctt tagccaatct 3506341 attggttcta aattaaacgc aggaagatac acgccatctg cgcaagattg aatgtaatcg 3506401 tttttcttat tgtctgaatg ctcactttca ataaaatccg ttaaaaagac aatagcatcc 3506461 tccaaatatt ccttactttc ctctattaat aactcttgta tagcgtcatc aggagtttca 3506521 atatcttgat ggaatgttcc agctaaaaac tgaaaaacag ggtccttctg tttattgatc 3506581 aataacatgt catcttgctc ctttaaggga gaggtaacgg gataatgtta aaatcattca 3506641 tcatctaata aatcaagata atactgatca ttctcttcta tttttcttaa gaactcggta 3506701 agagaagttg caatttgaat atcataatag taaatcggat ttttattatt atcatttaat 3506761 tcaattgaca ttaatgccga ttcactacct tcaaaaaata ttaatttatc attctcaaac 3506821 tcatcatata tttctatgtc aggataaaat tcaaagtcat ttatcctcaa tcgaaagtct 3506881 cttacagaat atggatccaa aatgcgatta gtattaaact ctgatccttt aataaaccca 3506941 tagccaactt ctaaataaaa attcactaat tcactaggta attttaagtt taaatttttt 3507001 tcaacctctt caatctcact ttgattcact ggataaaaat cattttcttt gtttgatttt 3507061 ataaaattat aactcatttt tttttgcctc ctttaaataa ttcatttgct ggtgagcctg 3507121 taccatgaat cccagcttga tgctcgttag gaaattttgc tggatgcata ttccaccatt 3507181 catgttctcc gccaaaagta ttttcaatta tatggtgagc atcatactta tccccttttt 3507241 ttctaataat tttacctgtt ttttcagata caacattttc cttataaaca ggccattttt 3507301 gtccagtgtt ttcttcccat tcttttataa ctttattttt tactttatca aatttagtcc 3507361 tgtgttttgc agtctctatt ggtgacattt ttttatattc tttatttctt aatgcttcct 3507421 ttaatttatc tatttgattt ttaggtaatt ctctacctgt gcgttgttct atatctctag 3507481 catacttttt tattaaatca gaattaattt tattagcaga tccacttaca tcattcgcaa 3507541 ttttcccttt atccttagca acgtttttaa cttccgaagc cttcttagcc tttttcccat 3507601 tattaataag tttattaata tctattaact tttctaactt agctattttg gcaaatggta 3507661 ctgagtttat ggaggcaaca acacggtctt tccctgtgac tttttcgcct gataccggat 3507721 ctctgcccgt ggctgcttta aatagatcat acacgccggt aagttctaca gccgtctcta 3507781 aaattttcac atatccattc tcatccactt taatgtccga aagcgagacg acaggttcaa 3507841 gcttcatgtc attaccagat atgtatacat tgtaaagtgt atcattataa acgacttgct 3507901 taacctctgc atttgagaaa tcagttttta tatgttctct atgttcactc gtattataca 3507961 ctttaccatt gataacgatg atatttttac ttaccttttt agaatcaccc gttttgacaa 3508021 ctgaatccac tttagacttt tcattctcgg ctaatttctt cagcatcatc tccatcggtg 3508081 aatcatccgc ctgcttcatt tgcgggttaa tcgcgccgaa gatttggttg atgttttctt 3508141 cttcctgtga tttcaggatg gagccgcttt tgtagcctgt gatttcaatt ttcgggccgg 3508201 tgtacatggt ttcgagctga tcaatgtatt ttttcatcgt ttgaaaatct gattttgcgg 3508261 cttctagtgc ttgggtttgc tggccgtcaa attgaaagag cttattcagg gtgtctgaaa 3508321 tcagccgctc agcctgttct gtttccatcc gaaaaaagga atcattgact gtcggcaggc 3508381 tgacgatgtg atctatggct gatgtctggc gattgactgc gtcagtgagc tgctctgtca 3508441 cttctcgtgc atgcttgacc ccatgtctcg catcgtgtga gagaaaagcc tctgcgatca 3508501 tgccgtggga gttagattct acagaggaaa tcgcatgctg tgtttgtttc agcacttttt 3508561 tgtattcgtc gataaatatg ccaaagaaaa ggagaaaagg cttgtggcac tcctcgtaaa 3508621 aggtccggat ggcatctccg ccttttcctt tcagcgcatc cttcatgcct gccagatgct 3508681 caacgctttt ttccagcttc tccagctgtt gtttttgctt gtccagtttc tcaatcgtat 3508741 gctgaatgcc ctcgtgaaga gcgtggacat ctaatgtttt caatcccttg tcctcccgcg 3508801 ctttatttca tggaagatga tatgttttcg tccgtttcct tcatggcgtt taccgcgctt 3508861 tccgtttgtg cgatatgctt ggccagaaca gacgcatatg cttcagtgag ctctttgatg 3508921 tccttattta attgctcgat ggacttcaca acattcaaat ggtttctgcc tgagagatga 3508981 ccgggcaatg aggacttgag ttcagctgaa ttcttgagct gagaaagccc ttgcttcact 3509041 gtgtcataca ccattttaat ttcctgtgcc atttgtgctc acctcacttt ttatgttttt 3509101 ccttctctat ttcatgctct atcctcgtga tttggcgtct tatagaatac acatcgccct 3509161 ctaatgagtg gatttttcct tctatgcttt cgatgattcc gctgacttga tcgcttttga 3509221 tttgctgata tgctttgttc attccttcac gaatatcttc aaaccgctca gcatgtgttc 3509281 ctctccatgc ctcccggtta agatgaggcc ggtgaatgag atgctgggcc tcagagaaat 3509341 cgtgtttgat ttgcctaatt tcgtgcagca ctcgttttaa ttgatggatc tgttcctgct 3509401 tttcatgtaa gtcggctttt accgaatgta acaacatttc actatgcatg ccgcaacacc 3509461 tcgtgtttct atcaaactgt gtaaattctt tacaatacag actattttca tattacatga 3509521 tgggtcatat tggataaata ggtaaaaagg attgtcttga gaggtataga actggttcta 3509581 aattgctaaa aatacgatct catcacccta tgaaaggaga aaacaatcat agtagggact 3509641 ttttatttaa gcctttaatc tctcctccag ttctaatttt tcctcccact taactgtttc 3509701 ttatagtcaa taaagctcat aaaaaaacac cttccctcga aggcgcttct ccatcttatt 3509761 tagatcccca tacagcctca ccgctggtat tcagcacact aaacgtcatg acgttcttct 3509821 ctctcaccga atcccactgg cgtaaaaata ccccgttata cttcttgcct gctaacgtga 3509881 tgtcggcggt gttttttccg gttttcctcc atgttccggt catttccccg gaaatggtgt 3509941 ggtttttgtt gagctggatg ttgatggttt gtttgatgtc ggctgagatg tcttttccgt 3510001 gctggataag tttgtatgtt cctgtgatgt ctttttgttt tacttctttc aatgtttcgc 3510061 ccgcataacg atatggtgct gctaccggcc agccgtcttt gttcatgaac aattggtgga 3510121 ctctgacttc gtgttcttca cccctgcccg ggaagcgggt gtggaagatt aaataggaac 3510181 gcccggtttt ttcatcatag tatgcggagt tgtggcctgg tgagacgtac ccggtgcctt 3510241 tttcattttc tgtttcaaaa gtgtagctgc ccatgagttt gacgccgtat ggttcgatgg 3510301 aacggtcgtc gaagaatgtg cctcccttgc cgcggacgtc gagcattgga ttgccttctg 3510361 catcatagta agggccgtcc ggtttcttgg agcgggccac acggatgttg tagccgcctg 3510421 ttgcatcgag accgccatat gataggtata agtagtagta ttgggtgtct ggattgtaga 3510481 gaacatacgg gccttcgatt ctgctgtggt tgccgccgag cagttttttc ccatatccct 3510541 gtccaggaag cgggaagccc gttttcggat tcatttcaag tatgaaaatg ccgcctgagt 3510601 atgatccgta caccatccac agcttgccgt ctttatcaaa gaaggtatgc gggtcgacga 3510661 cattcggatg tttggttgca tcatacggtg ttccatcgct gcttgtgcct tccattcctg 3510721 atttcaaaaa gatgcctttg tttttgtatg ggccttcgat gttgtcagca acggcaacac 3510781 ccatggcgga tcttggcgaa tcgccgcggc aggcgttgta gtacatgtag tatttgccgt 3510841 ccgccagctg cgtgacgtca gccgcccaaa gagtatcgga ttgcgcccat tcgaaggttt 3510901 cttttaattc ttcatagaca ttcgggataa gtgggttgtc attgcttacg ctggtggtca 3510961 gctgctgcca ttgcatgagg tcattcgatt tagctgaagc gagatgagat ccaaaaacat 3511021 aaaaagtgcc gtttgtttca atgatggaag ggtcatggac gctgacttct ttaaatatag 3511081 gtttttgtgc atagacggag tttgggaggg tgaaggccat gataagagct gcaagaaaac 3511141 atacacggaa caatcggttg aacatctaaa caattcgcct ctctttttta ttaaatttta 3511201 aacgcttaca tttctctatg aagatacccc ggcctattaa aacagccgaa tgttttcata 3511261 ttcatccaga taggtgattt ctcacttcac ttacatagtc agactgatgt ctgtctgttt 3511321 tgcgcagaac ttgttgcttg catatcctct ccttcatagt tcaactcttt tgctgtttct 3511381 ccttcttgca tcacgtctgt ttttctttcg cgtacatgta ataactgctt tgtcaggttt 3511441 tgcatcaact gtgatacagc catttcgttg tcggcgtttt ttaagatgat gcctgattgc 3511501 ccgtcaacac cagagtcatt cggctggctc tttataaaac gccttgcgaa aaatacgact 3511561 tagtaaacgc atattgagag ttagacagcg gcgcttgcct ccttgtctgg atatcgtgtg 3511621 caatcgctga aaaaacctgt tctgctttct gcgtcacgct attacaatag caatctaact 3511681 tgttaaagac tataaaaaaa ccttttgact tctgctgctg aaccaattaa tataatactc 3511741 agttaatagt tatcagaatt tttaggaatt gagtgattca tatgacactg cataaagagc 3511801 gtcggatcgg ccggctgtct gttctcctgc tgctgaatga ggcggaagaa agtacgcagg 3511861 ttgaggagct ggagcgagac ggatggaagg tctgtcttgg caaggtagga tcaatggacg 3511921 cacataaagt agtagccgca attgaaaccg cttccaaaaa gagcggtgtc attcaatctg 3511981 agggttatcg ggagtcacat gcgctttatc atgcgacgat ggaggctttg catggcgtga 3512041 ccagaggtga aatgctgctg ggatcgctgc ttcggacggt gggattgagg tttgccgttt 3512101 tgaggggaaa tccttatgaa agtgaagcgg aaggcgattg gatcgctgtc tcgctttacg 3512161 gaacaatcgg ggcgccgatt aaaggtcttg agcatgaaac attcggcgtt ggaattaatc 3512221 acatatgaaa cagcccatag atcttagacg atagggggct atgcgtgaaa acagaagttc 3512281 acagcatagc tcctttttgt atgggcgctt taccaaagta aagaaaaagg agttgggctt 3512341 atggtgactt tagacggttc ttcattgaca acagccgacg tcgctcgtgt gctgtttgat 3512401 tttgaggagg cagcggcttc tgaggaaagt atggagcgcg tgaaaaaaag cagagcagca 3512461 gtggaacgga ttgtacgcga cgaaaagaca atctacggca tcaacaccgg atttggcaaa 3512521 ttcagcgatg tcctgattca gaaagaagac tcggcggcgc tgcagctgaa tttaatcctt 3512581 tctcatgcct gcggagtcgg cgaccctttt cctgagtgtg tttccagggc aatgctgctt 3512641 ttgcgcgcca atgcgctgtt aaaaggcttt tccggtgtac gcgctgagct gatcgagcag 3512701 ttgcttgctt ttttaaataa acgcgtccat cctgtcatcc ctcagcaagg atcacttggc 3512761 gcaagcggag atctggcgcc gctttcccac ttggcgcttg cgctgatcgg acaaggagaa 3512821 gtcttttttg agggggaaag aatgccggca atgacaggct tgaaaaaagc aggtattcaa 3512881 ccggtaacgc tgacatccaa ggaagggctt gccttgatta acgggactca ggccatgact 3512941 gcaatggggg tggtcgccta catcgaagct gagaaactag cctatcaaac agaacgaatt 3513001 gccagcttaa cgattgaggg gttgcaggga attatcgatg catttgacga ggatattcac 3513061 ttagcccgcg gctatcagga gcagatcgat gtcgcagaac gaattcgctt ttatctatct 3513121 gacagcggcc tgacaacctc ccagggagaa ctgcgggtac aggatgccta ttcattgcgc 3513181 tgtattccgc aagtacacgg tgcgacttgg cagacactag gatatgtcaa agaaaaatta 3513241 gagattgaaa tgaacgcagc tacagacaat ccactcattt tcaatgacgg tgacaaagtg 3513301 atttccggcg gaaactttca cggacagcca atcgcctttg ccatggattt tctgaaaatc 3513361 gcaatatcag agcttgcgaa tatcgcagag cgtaggatcg aacgacttgt gaatccgcag 3513421 ctgaatgacc tgccgccgtt cctgagccct catcccggtc tgcaatccgg tgcaatgatc 3513481 atgcagtacg ccgcggcctc actcgtttct gaaaataaaa cactggccca tcctgcaagt 3513541 gtggattcca ttccgtcatc cgccaaccaa gaggaccatg tcagcatggg aaccatcgcc 3513601 gctcggcatg cttatcaggt gatcgcaaat acaaggagag tcattgcgat cgaagccatt 3513661 tgcgcattgc aggctgttga atacagaggc atagaacatg cagcgtccta tacgaaacag 3513721 ctttttcaag aaatgagaaa agtcgtgccg tccattcagc aggaccgtgt tttttcctat 3513781 gacattgaac gcttgactga ctggctgaag aaagaatctt taatacctga tcatcagaat 3513841 aaagaactaa gggggatgaa catatgactg atgtaaaaaa atcaatccgt gccaacagag 3513901 gaacagagct tgaatgctta ggatgggagc aagaggcagt gcttcggatg cttcgaaaca 3513961 accttgatcc agaagtcgcc gagaagccgg aggacctcat cgtatatggc gggattggca 3514021 aagccgcacg ggattgggac gcttttcacg ccattgagca ttccttgaaa acattaaaaa 3514081 atgatgaaac attgctcgtg caatccggaa agcccgttgg catgttccgt acacacccgc 3514141 aggcccctcg cgtgctccta gcaaattctg ttcttgttcc gaagtgggca gactgggagc 3514201 atttccacga acttgagaaa aaagggttaa tgatgtacgg acagatgacg gctggcagct 3514261 ggatttacat tggctcacaa ggcatattgc aaggaaccta tgaaaccttc gctgagctgg 3514321 cgcgacagca cttcgggggc agcttaaaag gaacgttgac gctgacagcg ggtctcggcg 3514381 gaatgggagg cgcccagccg ctgtcagtca cgatgaatga aggcgtcgtg attgccgtcg 3514441 aggttgacga gaaacgcatc gacaagcgga tcgaaacaaa atactgcgat cgaaaaacag 3514501 catcgattga ggaagcctta gcttgggctg aagaggcaaa gctggcagga aaacctttgt 3514561 ccattgcact tctcggaaac gcagctgagg tgcatcacac acttttgaac cgaggcgtca 3514621 aaattgatat tgtgacagat cagacatctg cccatgaccc tttaatcggt tatgttcccg 3514681 agggctattc ccttgatgaa gctgaccgtt tgcgtcaaga cactccagag ctttacgtgc 3514741 gccttgcgaa gcaaagcatg aaaaaacatg tcgaagccat gctggccttt cagcaaaagg 3514801 gctctattgt atttgactac ggcaacaata tccggcaagt cgcaaaggat gaagggctgg 3514861 agaatgcctt cgattttccg gggtttgtcc ctgcctacat ccgcccctta ttctgtgaag 3514921 gaaaagggcc gttccgctgg gcggcgcttt ccggagatcc ggcagatatt taccgtacgg 3514981 atgcgttatt aaaagagctg ttcccgacaa ataaagccct tcaccgctgg attgatatgg 3515041 cacaggaaaa agtcaccttc caaggcttgc cgtcccgtat ctgctggctt ggatatggag 3515101 aacgaaaaaa gatgggcctc gccattaacg agctggttag aaccggggag ctaaaagcgc 3515161 ctgtcgttat tgggagagat catttggact gcgggtctgt cgcctctcca aaccgggaaa 3515221 cagaagcgat gaaggatgga agtgacgctg tcggtgattg ggctgtgcta aatgcgcttg 3515281 tcaacacggc ggcgggtgca agctgggttt ccttccacca tggcggcggc gtcggaatgg 3515341 gctattccct tcatgccggc atggttgcag tggccgatgg aagtgagctg gctgacgagc 3515401 ggctcgcgcg ggtcttaacg agcgacccag gaatgggcat tatccgtcat gcggatgcgg 3515461 gttatgaacg tgccgttgaa gtagcgaagg aacaggacat tatcgtgccg atgcaaaaat 3515521 aaaggagtga tgacatgcca aagcaaattg atacgattct catcaacatc ggtcagcttt 3515581 tgacgatgga aagcagcggt ccgcgggcag gcaaaagcat gcaggatctt catgtgatcg 3515641 aagacgctgt tgtcggcatc catgaacaga aaattgtgtt cgccggacaa aaaggggctg 3515701 aagccggtta cgaggcagac gaaatcattg actgttcggg acgccttgta acgcctggcc 3515761 tcgttgatcc gcacacccat cttgtatttg gcggatctcg tgaaaaggag atgaacctta 3515821 agcttcaggg catttcatat ttggatattc tggcgcaggg cggcgggatt ctgtctacag 3515881 tcaaggatac cagggcggct tcagaagaag agctgctgca aaaagcccat tttcatctgc 3515941 aaagaatgct gtcctacggc acaaccacag cagaagtgaa aagcggctac ggcttggaaa 3516001 aagagacaga gctcaaacag ttgcgtgtcg caaagaaact gcatgaaagc cagcctgttg 3516061 accttgtttc cacatttatg ggagcccatg cgattcctcc cgaatatcaa aacgatccag 3516121 atgattttct ggatcaaatg ctttcccttt tgccggaaat caaagagcag gagctcgcca 3516181 gctttgctga tatttttaca gaaacaggcg tttttacagt cagccaatcc cgccgttatt 3516241 tacaaaaagc agctgaggca ggcttcggat taaaaataca cgcagatgaa atcgatccgc 3516301 ttggaggtgc tgaattagca ggtaagctaa aggccgtctc agccgaccat ttggtaggta 3516361 catcggacga aggcataaag aaattggctg aggcaggaac gatcgccgtc ctcttgccgg 3516421 gcacgacatt ttatcttggc aaaagcacat acgccagggc aagagctatg attgatgaag 3516481 gtgtatgtgt cagcttggca acggatttta atcctggcag ctcgccgact gaaaatatcc 3516541 agctgattat gtccattgcc gcgcttcatc tgaaaatgac tgcagaagaa atatggcacg 3516601 cggtcacagt caatgccgca tatgccatag gaaaaggaga agaagccggt cagctcaaag 3516661 ctggccgctc agctgatctt gtcatttggc aagccccgaa ctatatgtat attccgtatc 3516721 actacggggt caatcatgta catcaagtca tgaaaaatgg aacaattgtt gtcaacaggg 3516781 agggagccat tcttggataa gtaccctttt ctcagagagg ccggatcttc gtttaaagac 3516841 cgggatgtca caaaaatgag cgacctgatc gcaacatggg acggccagga cattaaggga 3516901 ccggcgttga taggtgtccc cctatcaaaa tcctccatca gtcattcagg cgcttccttt 3516961 gcacccggaa caatacgcca ggctctgaaa cattcatcag cctattctgc tgagcttgga 3517021 gagcacgtcg tatcagagct tctatatgac ctgggggata tcgatattca tgtcactgat 3517081 atcgtaaagt cacatcatca cattttccaa accatgcacg ctctgctttc ggatcatccg 3517141 gattgggtgc cgctcatact tgggggagat aactctatca gctactccac aataaaagcg 3517201 atagcacaaa caaaaggaac gacagcggtg attcaatttg atgcccatca cgatgttcgc 3517261 aatacggagg acggggggcc gacaaacggc acccccttcc gccgcctttt ggatgaagag 3517321 atcattgaag gtcaacattt gatccagctg ggtatcagag aattcagcaa cagccaggcc 3517381 tatgaagcat atgcaaaaaa acataacgtg aacattcaca cgatggacat gatccgggaa 3517441 aaaggactaa tcccaacgat aaaagagatt ttgcctgttg ttcaagataa aacagatttc 3517501 atttttatat ctgttgacat ggatgtctta gaccagtccc atgcacccgg ctgtccagcg 3517561 attggcccgg gcggcctcta tacagacgaa ttgcttgaag cagtcaagta catcgcacaa 3517621 cagcccaatg ttgccgggat tgaaattgtt gaagtcgacc ctaccctcga ttttcgagat 3517681 atgacaagca gagctgcagc tcatgttctg ttacacgcat taaaaggaat gaaactctcc 3517741 ccattcaagt gatcttctgg caggttgtat tttgggtata agaaactcat ctgcctaagg 3517801 aatggcagct aaaaggaggg cgagacagtg aatcttcagg agaacagcag ccaacagcta 3517861 aaacgcacaa tgaaaagcag gcacctattt atgatctcat tgggaggcgt cataggcaca 3517921 ggacttttcc tcagtacggg ctatacgcta catcaagccg gacccggcgg tacgatactc 3517981 gcttatgtaa tcggcgggtt gatgatgtac ctcgtcatgc aatgtctcgg cgaattgtcg 3518041 gttgccatgc cggtgaccgg ctcttttcaa aaatatgcta caacatttat cggtccatct 3518101 accggtttta tggtcggcat catgtactgg atcaattggg tggtgacggt aggctctgag 3518161 tttaccgcat ccggtattct catgcagcgc tggttccctg acagcagtgt atggatgtgg 3518221 agtgcgattt ttgcagccct tctttttata tgcaacgcat tttcagttaa gttatttgcg 3518281 gaaactgaat tttggttttc cagcgtaaag attgtcacca ttattttatt tatcatttta 3518341 ggaggagccg ccatgtttgg cctgatctct ttaaacggaa cggcggatgc tcctatgttg 3518401 tcaaacttca cagatcatgg cgggttgttt ccaaatggct ttctcgccgt ttttatcgcg 3518461 atgatatctg tgagcttcgc cttttccggt acagagttaa tcggcgttac agcaggagaa 3518521 tcagcaaatc ctcaaaagga tataccgcga tccatccgta atgtcgcatg gagaaccgtg 3518581 atttttttca ttggcgctgt cttcatatta tccgggttga tttcatggaa ggacgcaggc 3518641 gtgattgaaa gcccgtttgt cgccgtattt gcggagatcg gaattcctta cgctgctgat 3518701 attatgaatt tcgtaatatt aacagccttg ctgtctgtcg ccaactcagg cttatatgct 3518761 tcgacccgta tgatgtggtc tttagcaaat gaaaacatga tcagctcccg ttttaagaaa 3518821 gtgacatcta aaggcattcc tttaaatgcc ttaatgatca gtatggctgt atcttgttta 3518881 tctctcgttt ccagtatcgt ggcccctgga actgtctatg tggtgatggt cgcaattgct 3518941 ggatttgcag gagtcgtggt ctggatgagc attgccttgt cccaactctt gtttcgaaag 3519001 agatttttga aaaaaggggg ggatgtaaaa gatctgacat ttcgcacgcc gctttatcct 3519061 cttatgccta tagccgctct cttattatgt tctgcttctt gtatcggtct tgcttttgat 3519121 cccaatcaaa gaatcgcact tttctgcgga gttccttgta tcatcctttg ctatctcatc 3519181 taccatttca aaagaaatgt tacaaaagcg aaaaaaatca gccaagagga atatccagcc 3519241 gatcacatcc tataattaaa aaagcacacc ccgctcagca tgggatgtgc tttatttttt 3519301 attctgtaat taacgtatga atcagcttcg gcgccttcgc ttccgcggcg atgcggatgt 3519361 tgtcatagac ttttgcgatg acttcatcga cgttttctcg gttagcgtaa agcgttacga 3519421 gcggttcccc tttttctact ttgtcgccga cctttttgcg gagcatgatg ccgacggcta 3519481 aatcgatttc gtcttctttt gtggcgcggc cggcacctaa cagcatcgcc gcgacgccga 3519541 tttcgtccgc gacgatttca gagacgacac ccgcttcttt ggcaggcaca tcaatttgat 3519601 atgcggcttg cggaagctta gacggatcgt caacaattga gctgtcgccg ccttggtttt 3519661 tcaggaaatc cttgaatttc tcaagtgctt tgccgttttt catgacttct tccagcttcg 3519721 ctctcgcttc gtccaatgta tcggcttttt tcgcaagcac aaccatctgg ctgccgagcg 3519781 ttaagacaag ctcatgaaga tcctcaggcc cctcgccttt gagcgtgtcg atcgcttctt 3519841 tgacttcaag cgcatttccg atcgcaaagc cgagtggctg ggacatgtct gaaatgacag 3519901 ccattgtttg acggccgacg ttatttccga tgcgtaccat cgctttggca agttcagctg 3519961 cgtcttcttc tgttttcatg aaggcgcccg ctcccgtttt tacgtcaagc acgatggcgt 3520021 ccgccccggc agcgattttt ttgctcataa tcgagcttgc aatgagcgga atggaattga 3520081 ccgttcccgt tacatcacga agcgcgtaca gttttttatc agccggcgtt aaattgccgc 3520141 tttggccgat gaccgcaacc ttgtcgcggt tcacaagttt aataaattca tccttcgtca 3520201 gttccacgtg gaagcccatg attgcctcta acttatcaat cgtgccgccc gtatggccga 3520261 ggccgcggcc ggacatctta gcaaccggca catcaagagc cgcaacaagc ggagcgagaa 3520321 cgagcgttgt cgtgtcgccg acgccgccgg tagagtgttt atccacttta attccttcaa 3520381 tggcagaaag atcaatcgtt tcaccggagt tcaccatagc catcgtcaag tccgcgcgtt 3520441 cacggtcact catatcctgg aagaaaatcg ccatagcaag cgcgcttgcc tgataatcag 3520501 gaatgcttcc atctgtatag ccgttcacaa aaaattgaat ttcttcagtg gtgagttctt 3520561 ttccgttttg ttttttgatg atgatatcta ccattctcat gtttggtcac cgatcctttt 3520621 cgattaagtt cagtaaatca agcccacaat tgctgctgat aaaaagctga caagcgtagc 3520681 accgtataat aatttcaagc cgaaacgagc gacgacattt ccttgctttt cattcagtcc 3520741 ttttacggca ccggcaatga ttccgattga ggagaagttc gcaaatgaca caaggaatac 3520801 cgatacgatc gctgttgtac ggccgctgaa atggaaaccg ttttgcgtaa gcgacgtcat 3520861 ggcgacaaat tcattcgata ccatttttgt tgccataatg cttcccgcat taacagcttc 3520921 attccatggg ataccgacaa gaaaagcgaa tggagcaaac acatatccaa gaatgccttg 3520981 gaacgaaata ccgaatactg cattaaaaat gccattgatc aatgcaataa tcgcgacaaa 3521041 tccaatcagc atcgcagcga cgacaaccgc tactttgaaa ccgtcaagaa tgtattctcc 3521101 gagcacttcg aagaaggatt gtttttcttc ttcctcaaca cgaagcatat cctcttcttt 3521161 tgcaacctcg tacggattga taatagaagc gataatgaaa ccgccaaata agttcaaaac 3521221 aagcgctgtt acaacatatt ccggtttcag cattgtcata tacgcaccga caatcgacat 3521281 tgatacagtt gacatcgcag atgcgcaaag cgtgtacaag cgctgctgat ttaaaagacc 3521341 gagttctttc ttcaaggaga taaatacttc tgactgccct aaaatcgcag aagccactgc 3521401 gttatacgat tccaatcttc ccataccgtt taccttgctg agggcaaggc cgatatatct 3521461 aatgataaac gggaggactt tccacttttg cagaatcccg atcagagcgg aaataaacac 3521521 gattggcaag agaacattca taaagaatgt cgtttggtcc gcattcacca agccgccaaa 3521581 cacaaagtta attccctctg ccgcgtattc aagcaggtaa ccgaatcctt ttgcaaatcc 3521641 tcccacgagg aaattcccta ttccggtatt gaggagaatg tagccaagaa taaattgcaa 3521701 aatgagcata acaacaattg ggcggatctt aattcttttt ttgccgctgc tcgcgatcca 3521761 cgcgaggcct aaaaacacga ttaaaccgat aatcccaatc aaatacttca tatgtgtttc 3521821 tcctttattt gtattcgctt acaattactg tttcctcaga aaacggaaag cagtctgcct 3521881 tccgtcagct cttaatagtt gtctccgcct gatgcatttt ctccttttac gatagaaacg 3521941 cctgcgctgg cgccaattcg gcttgctccg gcctctacca ttgtgtctac atcttctttc 3522001 gttctgacgc cgccagatgc tttcacgccg atatcaggcc ctactgtttt gcgcattaag 3522061 gcgatatctt ccttcgttgc gccgcctgta gaaaagcctg ttgatgtttt tacgaaatcc 3522121 gctcccgcag acaccgctaa acggcatgca cgttcttttt cttcatcagt cagaaggcac 3522181 gtttcgataa tgactttgac aagcgctttt ccggctacag cttccactac accgcggata 3522241 tcagcttcca ccacatcgtc ttccttgtct tttaaagcgg caatattaat gaccatatcc 3522301 acttcagtgg cgccttttga aatggcgtct tttgtttcga acgcttttgt ttcagttgta 3522361 ttggcaccga gcgggaagcc gatgaccgta caaacgtcga ctccagttcc cttaagctct 3522421 tttgcagcaa gctccaccca tgtcggattg acacatactg aagcaaattt gtatgttttc 3522481 gcttcttcaa ttagttttag aatgtccgct ttttgtgtat gcggtttcaa agctgtatga 3522541 tcaattatgt tggctaatga catccttcgc acacttcctt ttttgttaag atatttttta 3522601 gcataaccga cttttgaaca tatgtaaatt ggtaattgaa attttgttca atgaaaggtt 3522661 tgaacgtgtc acaaatcatt aacaagcgcc ctcgcggtat gctggtcaat gattaaaacg 3522721 ttggcatatt ttccggttaa tgctccgtga atggaagata cttttctgct tccgccggca 3522781 actaaaatgg agcgttcctt cagtctaagg tcttgaagct caacaccgat ggtccggtca 3522841 ttgatggcgc tgctgcaaat attccctttc gcatcaaaaa agcgtgaaca aatatccccg 3522901 acggcctgtt ttttcagcag ggctttctct tcttcgttaa aatatccgag ccgaaacaac 3522961 agcgcttcat cacggacagt cccgaccgta aagagagcga tattcgcctg cttgcccatc 3523021 tcaatgatcc gttcaatatg acggtctttc tccaccattc gcttcacatc cgcattatca 3523081 aacacgacgg gaagcgggag atagcgcggc atcgtttgaa aagcctctgc aaacagctga 3523141 atcgtttcag ccgaatacgt gtttacccgg gaatggctga tgccgccttt cagctggacg 3523201 acctcgacgc cttttacctg cttcggctgc atgttttgcg cgatttgata catggtggtt 3523261 ccccagctga cgccgacaat gtcgccgtct tttaccgttt catgcatata ttctgcacca 3523321 tagcggctta ggtcatgtgt aattcctgca taatcgggtg tcggggaaaa cacaacatgc 3523381 gcctcaagga gcccgtattt ctcttcaagt atggaaccga gcgcatccaa atcctcaaaa 3523441 gggtccatga cgcgaatctg gacataccct ttttcctttg catattgcag cagccgggaa 3523501 acggttggcc ttgaaatgtt gagctgctca gcaatttgct gctgactgta gtcagactga 3523561 tagtaaagcc ttgccgcttc tatgcttaat tgctgttttt cccgatccat tctgcacctc 3523621 cctgtggatc agtcctgata aaactgcttt tgatttgctt ttattataca ggctggcgcc 3523681 ggctttcatc cacctgattt ctaagaaact gaaaaacgct ctgggcgcgg acctgcccag 3523741 agcttacttc tcccaagtca tatgctgata aatgcctttc ataatggcgt acattccata 3523801 taggatcagg cctaatgcca atatagacag aatcaatttg ccatgcggct gctgcgcgag 3523861 ttctgcgagc gcgccgtcaa agcctcttgt gtcgtcggga tcagcggtca tggctgtctt 3523921 gatgagaaaa tagccgatag ccgagaaaat aatggcccgg gcgatattgc ctgcgcgtcc 3523981 tgtgtttttc gtgatgcata tcatctgttt gttcattttt gatgtatcga attctttcat 3524041 aaaagcagcc cgaacgcctt tcataaattg aacaatcgca aatacgataa aacccgcacc 3524101 cgtaagccct gtgagccatt ggccgaacgg ctgcgccaat acataagcgg accacgtctg 3524161 ttctgaagtg ccgccgtccc cttggccaaa cacaaatcgc aaggcattcc aagcgatgga 3524221 tgtgtaaaca gcggcactga aaaagtttcc tattctccgc gacaggcctc gcctgctgtt 3524281 tccgtgcccc tccgtgtcct tgatcgcgct taacaccatc cagatcacat agccgataag 3524341 gccgatgcct ataaaaaaaa gcaatagtga cccatacggc atgcgtgata gcgtttggag 3524401 agctccgctc gaatctttgg cgcggcctgc cccggcagcc gtcataaaag ccaaaacccc 3524461 aagcagaata aaaacgccgc cgaatgcaaa ataaccaagc ctcccgaatc gtttgatcca 3524521 aggcttggtt tcctgtttta tttttgacat gtaccggtct ttcaccgcca tgtgtccaac 3524581 cctctttcac agaaatcttt actgtaacat tcccgattga acaaagttga aacagctcct 3524641 gcctcagcta tggctggctg agatacgttt ttgctgttta gctgattgtg caggtgtcat 3524701 ccaagcagcc gctgcggcag ctgtgactcc gcctgctaat ttcccaatga tcatggccgc 3524761 cgccatttct tttttcattc cagctacaaa accgagatgg ctgccgagta caaaggcgcc 3524821 gctgaccgca aacgcgacat tgatgacctt tcctctcggc gtcatatcct ttaatgaagc 3524881 cagcattggg atatgatgcg ccaaagaggt cactaagcct gctgttgctg tctcatctaa 3524941 atgaaggcat ttccccagag cctgaagcgg ttttttaaag gtttttgtaa taaatgccgt 3525001 catcgggaac gcccctgcca gagcaatggc gatggtccct gtcgtttgta tccctgtctc 3525061 gacattctcc attcccggaa tcagcacaat gccggtcatc gtttcaacag aaacagctgc 3525121 aagcccgata atcgcaacca tactgaccgc tttcccgaag agatgaaaca actgaatcat 3525181 tctgtcggtg tatcgccata acccaaaagc gatgacagca gataacagac tcgggatcag 3525241 aagattttta cctatcatgc cgatgtcaaa gcctgcgcat aatccgccga ttaagcaacc 3525301 gatcggcact gtgcacagcc cgattaatat gcctttcgca aaatacggat gatcctcttt 3525361 ttcgatgatg ccaagagcga cgggaatcgt gaagacgatt gccggcccca tcattgttcc 3525421 taaaaacacc catgaaaaca gcccggcctg cggatctttc gccatttctc cagccagcgc 3525481 atatcctccc atatcaatcg ccaaaatggt gttcgcaaag gaagaaggat ccgcgccaat 3525541 cgctgtgtaa aacggagcaa caatgggaat caagattgct gccagcacgg gcgccagcga 3525601 tacaattccg atcatggaca gcgccagcgg ccccatagcc ttaaagccgt ccgcaaaccg 3525661 ctcgcctagc ccccatctgt ttcccaaaca ataatccgct gctccccata gtaaaaaggc 3525721 agccaaaatg aatacaaccg cgtcattcac cgtcatggtt ttctcctttt tcaaacgtat 3525781 gattggtttt atcatatcat ctgaaatcac cgaatagagt tgatcttatt caatatgagc 3525841 taaaaattct tttatatcgg ctttttcaac ggctgttata atgcgtcgcg ctttttcttg 3525901 cgggaccgtt aatgtcaatt tttctattat gtcttcttca gacagctcat ttcctggtgc 3525961 cccttttggg cagtccacac gcgcttcgca aatccggccg tctgataaat aggcccggac 3526021 aatcgtgaaa cggccttttg gaacggcatg aggagccggc tgaatagcat tgtcatatac 3526081 gcgctgaatt cgccccattg tcgtttgaac cccgtttggg atcggctggc tgctgaaatg 3526141 ttcaacggtc aggccgtgtc catgcaaagc aagagcaatc acatattcaa cgctgaaacg 3526201 gccttcctct ccagcttttg gagatctttc cgtcaatgca gcatctccgc ctggcggaaa 3526261 tatcacttca atacgttcgg tattggcagc agaaatggtt tcttcggaga taagctgtcg 3526321 taccgcatct gcagcatggt gtgccgcgga acaaaatgga tagattttaa accatagacc 3526381 cggctgcaca attctccacg gtgcccccca atcgtttagc aaagtgtgtt gtgctttctc 3526441 aacgtcaccg tacagactga agaaaccagt ttctccatca agtgccgtgc gggacccgcc 3526501 aaattctgat tgggccagct taacggccag caagccagcc tgagccgcca aaccggcgtg 3526561 cagcggtttc atttctgttc caaattgcac cctcatccca gcagattgcg tagccgcaaa 3526621 accaattgct ttttccaact cttcctgagt cagctcctca gcataaccta cggcgcaggc 3526681 agcagcgatg gcaccaagcg tacctgtatt atgccagccc ttctcatagt ggcggctgcc 3526741 aattgattct cccagccgtg ccatcacttc aacaccaaca acataagcgc caagaagccg 3526801 ctcgtcatgt ccgcgagcgg cagaagcaat aagggccggt acgatgactg cactggggtg 3526861 tcctcttaca tcggagtgga catcatcaaa atccaatgca tgggcgataa atccattgag 3526921 catcgcggat tgtaatggcg cggccttttt gccctgtccg ataacaggaa caaggggccg 3526981 gcctccttca tcctctatca gacggaggag cttttgaatt cctttatctt ctcttcctgc 3527041 gaatgaagcg gcagtaaaat caagtaatcc cttttttgct tcgtgaatcg cgtcaactga 3527101 atgctcaggt tgtgacgttc tcacagcctc tgcaagacct gctgtcagcc cttgtttgct 3527161 catttgatgg tctccaatac aataaccgcc agctccgcaa agtattgaga ggcaaccgta 3527221 agggcttctt catccagtgt aaaggccgga tgatgccact cctccgtccc gttcgttccc 3527281 atccagacaa aaaatcccgg aatcttctct tgatacagag cgaagtcttc tccgcccgga 3527341 gactgctcag cgtgaacggt ttgatagcca agccgtgccg cagcttcgga tgccgcattc 3527401 aaaaatgtgc cgtcattctg aacggaaggc aaataaggaa accacttgaa ttctgcttgt 3527461 gccccatagc ccgctgcaat tccttcagcc actcgtctca tatgctcggg aacagcctgc 3527521 ctcgcttctt tttgaaaggt tcgaaccgtc ccctccattt cagcttggtc tggaattacg 3527581 ttccacgagg tgcccgcctg tactcttgtg atactgacga ctgcgttttg cagtgagctg 3527641 atattgcggc tgaccacaga ttgcagcccg ctgatgattt gtccggctgc agcgattgga 3527701 tcaatactgt tatttgggat gccggcgtgc ccgcctttcc ctttgatgac gatctcaaat 3527761 cggtcaacac ttgccatgag cggaccttcc tttacaccaa tggtcccgac aggcagatcc 3527821 ggcttattgt gcatgccgaa aatcgcagaa acgccattaa gtacgccagc ttctagaacc 3527881 tttcttgctc ctgcggcaat ttcttcggcc ggctgaaaga taaagcggac tgtacctttc 3527941 agctcggccc ttctttgatt cagcaacatc gctgtgccaa taatagaagc agtatgaaaa 3528001 tcgtgtccgc acgcatgcat tgtgccatca accttagatg caaatggaag attcgtctgt 3528061 tcttggatcg ggagcgcgtc aatgtccgct cgtattgcta tcacggggcc gtcttcccgt 3528121 cctttgattt ctgcaatcac accagtcttc aattgaggga catcaagtat ttcgatttgc 3528181 tcctcctcaa gccaacggcg gatttttttc gtcgtttcaa cctcttgaaa tgacagttca 3528241 ggatgttcat gaagatcacg ccgcatattg attaaacggg tatgaaacgc tttgtcggcc 3528301 attgttcttc tccccttctt atataagctc tgcaggctct cccacctgct tgataaatcg 3528361 tttcgtccgt tcgtttttcg gatggtcaaa cagttcctct ggcgttccct gctcgataat 3528421 atggccgtct gccataaaaa tcacttgatc agcaacctct tttgcaaacg ccatttcgtg 3528481 tgtaacaatg atcatcgttg tttgtttttc cgcaatggac ttgatgacct gaagcacccc 3528541 tgtgacgagc tcagggtcaa gcgctgacgt tggttcatcc agcaaaatcg catgcggatt 3528601 gaccgcaagc gcccgcgcaa tgccgattcg ctgctgctgg ccgccggaca ttgtgattgg 3528661 atagctgtca gccttatgct ccagaccgac ttgtttcaga atctccattc caatacgttt 3528721 cgcttcgtcg cgtggtttat gttgagccac gattaaagct tctgtaatgt tttgcagagc 3528781 cgttttattt ttaaacagat tgtagttttg aaagaccatg gccgtttgct ggcgaagccg 3528841 atgtgcttcc ttgcgtgtaa acttttccgc attcagtttg gcttctccga tttcaataag 3528901 gccttgatcc ggacgctcta atagatttaa gcaccggaga agcgttgatt ttccggaacc 3528961 ggacggaccg atgattgcca ccacttctcc gcgtttcact tctagatcga ttccgtcgag 3529021 cacgacgaga tctttaaacg ctttgcgaat attttttact gttatcaact gatttcacct 3529081 ctaagtccgg tatggcttgc tcatggcacg ttcaaacaag tcctgcaaaa tgctgtagat 3529141 aatggtaaga acccaataga cgatcgcaac cgccaaatac gtctcaaaat atttgaggtt 3529201 tcctgaagcg tacatcttcc cttgggcgaa catctccatg acccctaatg taaaggccag 3529261 tgacgtttct ttcaggagcc cgataaatgt attgcccgtt gccggaatcg catttcggat 3529321 cgcttgcggc aaaataatcc gtctgtatgc ctgaaatttt gtcataccga cagacaggca 3529381 cgcctccagc tgcccgtcat caacagaatt gagggcggcc cggaagattt ctgccaaata 3529441 agctgcgttt tttaagctta acccgatgat ggcagctgtg agagctgtca ttttgctcat 3529501 ctctggaaat agctgcggca gcccgtaata gattaagaac agctgtacaa gtgtcggcac 3529561 gcctcggaaa aaggatatat acagctttga cagctgatga agcactggaa ttttgttttt 3529621 tgtaatgagt gcgagaataa gtcctccgat aatggcaaaa atcatagctg ctattgccat 3529681 aaacaaggtg atcggaaggg cctgaattaa agtcgggaac gctgatatca tgaattccca 3529741 atcaatcgtg ttcattctgg tgagtcaccg ccgtttctta atgcttctgt tctactgtga 3529801 tatcttcatt aaagtatttt tcagagagtt ttttcagtgt tccgtcttta cgcaattcat 3529861 ctagggcctt attgactttt ttgcggagct tgtcgtgcgc atcgtccttg gcaaatggga 3529921 atgcaacctg ttcgtaaaca atcggatctc ctgcaagctt taatggcaaa ccggtcttct 3529981 tgatttgcgc gatcaataca gttcggctgt tgacataagc gtctacacgg ccgtacgcaa 3530041 catccttcag cgtaccctct tgtgtttcgt acgttttgat attgattttt ttatcaggat 3530101 ctttgctttc aaggtttttc gcgtggtttg aaccgagaac ggctgcgact gtcttgcctt 3530161 ttaaatcgtc tactgatttg atgtctgtat tgtctttttt gacgacaatc tgtgttcccg 3530221 cataagcgta tggtttcgta aagttatacg tttccttacg ttcgtctgtc acagctacct 3530281 ggttggaaat ggtgtcaagc ttgcctgttt gaagctctcc catcagcccg ctgaattcaa 3530341 gcagcttcca gtccagtttc atgtcaattt tcttagcgac tgcttccatc acttccacgt 3530401 caaagcctgt cagctttccg ttttctttat aagcaaatgg gtaactttgt cctgtcgcac 3530461 cgacatgaag cacattgtca tcctctttac tgctgctgtt tccattgccg caagctgaga 3530521 gcaccgctaa taatgcagca acgaccagca ctgtccattt tttcatcttc atttgatttt 3530581 cccgcctttt ctatttttat agatcatgtc gcaattgttt tttcatatag actgtgatat 3530641 gcccttttcc aaggtcttgt tcacctgagc ggacatatcc ttttcgttcg tacatctcaa 3530701 tcagccacgg atgcttatcc gctgttccga gtgagacaaa cggaaccttt aacgtatcgc 3530761 gaaggattgt ttcctccagc cattgaagca gctttgttcc gattcctttt ttaccggtgt 3530821 cggggtccac agcaaaccac cagatatgcg gaacgccata cggtcccggc tgttttcccc 3530881 aaggcattct caaggtgatg gtcgcgatga tccgcccgtc ttcttccatg acgtagcaag 3530941 cattttcccg aatatttttc agcaccaaat ccaaatccgc atgagcagca gcaaaacgaa 3531001 tgccgagctt tcgaatcggt tcataagccc gcaatgtcag ctcgagaagc tgttcggcat 3531061 cacgttcaac tgcaaggcgg tatcgtggct tcatctagcg ttcctcctta ctttgcatag 3531121 cggtttaccg gcttttccaa accgaagtgc tctcgtaatg ttgtgccttc atattctttt 3531181 ctgaacacgc cgcgctcctg taaaatcgga accacttgat caacaaacac ttcaattcct 3531241 tctggaagaa gcggaggcat gatgttaaac ccgtcacacg ctttcgtatc cacccattcc 3531301 tgcatcttgt cggcgagctg ctccggcgtg ccgacgaaga tatggtggcc tctggagcct 3531361 gcaacgtatt tgtaaagctc tcgtatcgtc atattgtcac gttcagccat ctcctgaaca 3531421 agcttgaagc ggctcttcac cgcattggaa gcttcggcgt caagcttcgg cagcggccca 3531481 tcaagcggat atgccgacaa atcaattccg cctaagtaat tttggagaat ttgcagaccg 3531541 acagatggga taatcagatc ttggagctcc ttgtatttgg cttgcgctgc ttcttctgta 3531601 tcggcaatga ttgggaaaat acccggcata atggcaattt tttctggatc acgtccgaat 3531661 tccgcagcct gttctttaat ggattgataa aattcttgag ctgattccag gtggttttgt 3531721 gctgtgaaga tcacttcggc tgttttggca gccagcgctt ttccgtctcc tgatgatcct 3531781 gcctggataa tgaccggctg gccctgcggg gttcttgaaa cgtttagagg tccgcgaacc 3531841 gagaaatatt ctcctttgtg gttcagctca tgcatttttt ctttgtcaaa gaattcaccc 3531901 gtttctttat tacggataaa ggcgtcctct tcccatgaat cccaaagccc ctttacaatc 3531961 tcgacaaatt cctctgcccg ctgatagcgc aaatggtgtt caaggtgctt ttcaccgctg 3532021 aaattcagcg ctgttgattc aatagatgaa gtgacgacgt tccatccggc acggccattg 3532081 gacagatgat ccaatgacgc aaactgtctg gcaatatgga atggctcgct gtatgtagtg 3532141 gaggctgttg ctgtcagtcc gatttttgat gtgacctgcg ccaaagcaga gagcagggtg 3532201 aatggctcaa accttgttaa tacatttgga tgtgatttgc tgtcaattga aaggctgtcc 3532261 gctaaaaaca gcatatccag cttgcctcgc tccgctgttt tcgcaagctc tttaaaataa 3532321 tccaaattca tgctcgcatc tgacggcgcg tccgggtgcc gccaagacgc aacatgatgg 3532381 cctgtacctg ctaaaaatac ccctaatttg atttgtttct ttttgcttgt catggcgata 3532441 ctccttttat catgttttta ggctgaataa tccgaaaaat aaactcctat attcctagtc 3532501 gtttaatatg aataaatcaa aatgtacctt tgtcttggac gtttgtcaat gagttaagat 3532561 taattttttc tattcaagcg aaaagaccct tgcgtgacca tgagggaacg gcattgattc 3532621 attcaactag tgcaacctct atatcggcaa gaaaactgag tctaatgaag caaagactca 3532681 gttttcttcc aataatttca tataagattt cgccatttcc tttgcctttt cttcgctttt 3532741 gcaaaccgcc tatccattca gacgccgtaa cgattgtata aaaaaacagc tgactccaga 3532801 tattcaaacc ggaatcagct gattgatgtg aattaattaa gctcatgaat actctcttct 3532861 gctttagcgg aaaacacttt aggctccaaa cagtcaaggt cttcatgaaa taaatttact 3532921 ttttggattt gccgattgtc atagtggtgg aaatagtagt ttccagtttc gttgcacatc 3532981 acggaagtat attgcgtata atgaatttcg tcttcttccg ttatcactgc gccctttggt 3533041 atcgtcatat ttgccaaaat ttgaaaagcg gctgttacac ctttcgtttc atcggccgcc 3533101 ggctctagat gttctttcaa ataaacagct ctgacaaacc gggaaggcgg tgtataatcc 3533161 cccggcagac caacagttcc taagccttgg ccaaaagcag aaagggctaa tccgcccatc 3533221 tctttgctct ctaattgctt cggtctgatt cctgtatatt gctgcagatt ggttacatgc 3533281 catataaagt cggggctgtt cgtcatgaca ccaggttgat tatcatagac tttgaggccg 3533341 tctgctcttg gttctatcgt caggtttcgg cccgtccggt ctgacaatat ccagtgaagc 3533401 ggtaaaactg tatccaatag atctaatttt ttctctacaa tcgttaaaga tcgaatcttt 3533461 tcttttacgt cttccaaaga ctgacagact gacagcaccc atgtcacaaa ctcatgcggg 3533521 acaatgtgaa cggtatcttc ccgtatcgtt ttttcgtact ccgcatagcc cggaaaataa 3533581 agcgccgcac aagataaacc gctttcatta atgccgtcgg caaataatat atttccaagt 3533641 tttctcccca taccgataaa cgcgtactgt gtctgatggg cccttccgtc agcttcactg 3533701 ttccagctgt aacggcgcgg atagagaatc acctctgtcc ccagctgaaa tgcaaaatcc 3533761 attgttcttg ctaatacatg tttacggtca gcagtttcca atgtaagact tgtgcacatt 3533821 tgatcagtcc ccttttcaat tcagattaat atcatacata ttgtgaacga attggtttta 3533881 tcagcataac gaaagtcaaa tcgattcgtc aaagaattga cattacatca aataaaacga 3533941 aaaaatccag cctttagaag gctggatttt ttattattta gccaaaacaa gctcgtgaat 3534001 cgcatgtgca acgccatgtt cattattgga gcgtgtttga aagtttgctg cttccaatac 3534061 ttctgggatg gcgtttgcca tggcaacccc gcagcccgcc cattcgatca ttgtcaggtc 3534121 gttcccgttg tcgcctatgc acatgacttc cgcctgttca attccaagca gctgagccag 3534181 ctggcgtaca gcatttcctt tgctggcttc cgagtgcaga atttcataaa agaaaggcgc 3534241 gcttctgacc attgtatatt tttctctcac gtcttttgga atcgatgtaa tgacgcggct 3534301 taagttctcc ggtttatcaa taaacatcac tttcgggatg aggatatctt ttggcacctc 3534361 gtcaatcttg cggaaatgaa gcggcacctg tgtcacatag gattcgtata cggtaaattc 3534421 gctaatatcc cggttaggcg tatacaaatt agatgagtca aagaaatgca tcggcgtctt 3534481 cagctctaag ctcaggtcat ataatgaagt caaatcatca taaccgagag acagctctga 3534541 gaccacttca tttgtatgcg tattttgaac aagtgctcca ttatacgcaa taacatagtc 3534601 gccttcttca attaaattca gttcatctaa atatctctgc acacccccga taggccggcc 3534661 ggtgcaaagc acaattttga caccttccgc ttttgccgcg tgaagggcgt cgcggacctc 3534721 ctctgttact tcatgatgat catttaaaag tgttccatcc atatcaattg caattagttt 3534781 gtacatcctg catctccttc atgtcgtttt caggctatag tcccatcata tcgttttttc 3534841 tttttgatat tcaaccggaa gagatggttt tctccggatt ctgtttagac gccgcccttg 3534901 tcttcggata cgcaagcgcg gtttccgctt tctttctgcc ttgacgccgt tttctgcttt 3534961 tttctgtttc atcagcagaa agccggcagc tagaaaagga atgccggtta tattcaagat 3535021 ggcaagcttc acacccgccg cgatgaaaaa gaacccccat gaagatgatg gattccgtct 3535081 gatcatgacg taagccgcca tttccagaac gatcaggatg gcatgaagca ctatgccata 3535141 aatcagcaat acaagggcaa aaaacaaaac ataattcacg attgcccctg agtacatcat 3535201 agcgcgcatc atttgtataa acgataagga ctgcatggag ccgctgatga cattagggtt 3535261 atagatcgta tagtcactaa ataaatgttt gactttgaga aaagcccata atataaatat 3535321 ccattgaatg atatgtaaaa caagccccgc tgccaccagt ctttcagctt tttgatttct 3535381 catctttctc ctccctgccg gtctttgatt cgattcttgt catcgttttt ctctgtccat 3535441 tttgctccca tatcaatgtc ccgttttctc ctcttttcag cgtgcttttg agcggataat 3535501 aagggccgag gtactgaatc tcgatagacc cgtcagtgct ttgggaaatc accttgtatg 3535561 ccataaaagg cagctgtacc tctcctcttc cttccatcac ttccgtttcc acaacctcgt 3535621 cttcggtaaa tgtgactgtt gctgatttca caccgtccgt tggcccgggg gcacgcccct 3535681 catcccacgt tccgtaataa aacggcgtct cttctttttg ctgctggcag cccgatacca 3535741 tgatgcatac agcaattaaa aacaaaatgc catatttgtt tctcaagggg atcaccattc 3535801 tttcctcctt ttttgggcga atgccgtgcc actgtgccaa tgactacata agttataagg 3535861 aattcaccca caaggagact gatcacatga acccttatca atattacagc cctcagctgc 3535921 ctcagcagga accttactat agccactatg agtacaatcc ttatccgcag caggatgtat 3535981 acgatccata ccaaatggac agacagccgg cattggaaag aagaatcgca gcacttgaac 3536041 ggcaaaatga acagcagtca agagaattaa cccgtctgac aaacgaagac cgccgtcaaa 3536101 atcgggaaat tgcacggatt gccgaacagg tcaatcagtt aagccaggct gttgaacgcc 3536161 atacacgccg cctaaatcgg ctcaatcagc gcctccgtac agtagaaaac cggctgaata 3536221 tcccatttac tgcaggggaa ggcggtttct gagcgaaaca aagaaaaaaa gcggaatacg 3536281 attctcccat ctcagggttt cgttttccgc atttcttata tgttaaaacg gaacatttac 3536341 ataaaaaggg tttgtaccca gtatacaatc tttaccgttt tcattcaaag atagaggggc 3536401 tgaggaaaat aattgtagtt cctctttgac ggaatttctt ttcattcaag ttgcatgata 3536461 ataccgactc acgtcaatcg atacatggag ggatcattca tgcataatac acaacacggc 3536521 ttgcagcagc tgaaccaatg ccgccaaact gctcagcagc tcattcagca aacacagcaa 3536581 agcagccagc aatatcgcca aatgcttcat caggaacagc aaaacatcca aatgctgcag 3536641 cagattctaa accacgaaca acaagctgca cataccattc agcaagcact gcacgggcat 3536701 gacatggcga ttcaaaagtg ccagcaggtt gtcaacatgt gcaaccaaat gcaacaggaa 3536761 cttactggac aatccagcgt catgaatacg aatgtgtcta cacttccatt cggccaaaac 3536821 acgacatttc agcagcaatc ctaccagcag taacatataa aaagctcaac acaatgcgag 3536881 tgttgagctt tttttcttac tgttctttgc gaatatgtat atcctgaata gactgtttcg 3536941 gtgcatgaaa tctgctctcg gcttcacttc ttgcctcggc aaaagcccgc gcctccacat 3537001 gatctttgta gacatccagc tgaatcaaat acagcgggcg cactttaaat ccatgaataa 3537061 tggttaccgc ccataacggg accacaataa aaacaccggg cagatcgggc aaaacaaaac 3537121 caaacgcaaa aatgaaaaaa taaatgatgc cgtacatgat ccactttcta tttctaacct 3537181 tgatgccaat aaataaaaag gcaaaaaaac tggtaatggc aaaaggcatg aaaataaaca 3537241 gcatccacca gctatgcagc cattcccaag cggcacctct ttttgtaatt cccatatttt 3537301 tctcctccta tttacctata ataatcgatt aggcacaccg cgtcacccat aaacgggaaa 3537361 aactttctcc cttaaaaata gtgatagacg gagaacaggt ttcttgctat attattaatt 3537421 gataatgata atcattacta atctattgag atacatagtg ggagggttct tgatgaaaaa 3537481 gaacatattg ctcgtgggca tgcttgtgct gcttctcatg tttgtcagcg cttgcagcgg 3537541 cacggcttct aaagggagct caagcgattc tgcttccgaa aaaacagaaa tgagaacata 3537601 caaatcacca aaagggaacg tcaacattcc tgcacatccg aaacgcatcg tcactgattt 3537661 ttatgccggt gaattgctgt ctgtcggggc caatgtggtc ggctcaggct catggtcatt 3537721 tgataatccg tttttaaaat caaagctgaa aaatgtgaag gatgttggtg atccaataag 3537781 cgttgaaaaa gtgatggagc ttcagcctga cttaattgtt gtcatgaatg aagagaatgt 3537841 tgataaatta aagaaaatcg ctccgactgt tgtcatacct tataacacag cgaaaaacgt 3537901 agaagacaca gtcagcatgt tcggagatat cgccggagcg aaagaccaag caaaatcctt 3537961 tatggctgac tttaacaaaa aagcggaagc agctaagaag aaaattgccg gcgtcatcga 3538021 caaagatgca accttcggca tttatgaaaa cacagacaag ggcgaattct gggtgttcaa 3538081 tgacaatggc ggacgcggcg gccaagctgt atacaatgca cttgggttaa aagcgcctga 3538141 aaaaattgag caagatgtca tcaaaaaagg agagatgaaa cagctctctc aagaggttat 3538201 tcctgagtat gccgcagatt atatgttcat tacggattac aacccgaaag gcgaaagcaa 3538261 aacactcgac aagctggaga attcctccat ttggaaaaat cttgacgctg ttaaacataa 3538321 tcgcgtgttt atcaatgact ttgactcgtt ctacccgtac gacccgattt ctgtcagcaa 3538381 acaggtggat atcatcaccg acatgctgat caaacgggcc gaagaaaata aaaaataaaa 3538441 aaacggcaca gtcatgacgc tgtgccgttt tttatgattc actttaattt tgactgtacg 3538501 gagtccggca tatcttcaaa cttgacttct tcccaagtct cgacatactt tcctttcgcc 3538561 ttcaccttca aatacgcgtt cttccgaagc tctttgccgg cgaaaaaggt cacttcttct 3538621 tttttcccgg atgcattata tccgtctaat gtatattcag taccgcccgg actaagatgt 3538681 ctgccatctc gatcaatctg aacatagaca tcttgctggt gaataaacgg attaaatctg 3538741 tctgtaacat cgttatgaaa aaagagaagc ccgcatatta cggcagcagc cgccaagacg 3538801 gccaggattg ccattgcttt tttcatcttt gcactcccct tacttgttca tttttttcaa 3538861 atagcttgac cgcaccgcga ggaagaatag aagctgaaaa atgaaaaacc ctccgatggt 3538921 gagactgagc ggccccgcta catcggaata tccttccaca gccaatgttc tcaaggcaaa 3538981 cagtgtatgc atgacggcaa tgacaaatgg aaagaagaaa agaatcgcca attgtattgt 3539041 cacgctttgc gccatttctc gctcactcag gccgattttg gccagtgaac ggtagcgctc 3539101 ccggtcttca tctaaatcag tgaacagcct gaaatataag aaacttgctg ccgcgacaaa 3539161 gaatacaatt gcgataaaca ggccgataaa tagactcagg ctcggcagct gcaccgtatc 3539221 atagtaagtc cccgcttttg aagcaaaatc agaatgcacg tcgatataat tgccgtaaat 3539281 ctcattttgc aaggattggc tgatctcaag actgtctttc caatgatcat agctgtagcc 3539341 gtataatgac gctttatcac cgagtgattt cagctgatca aaggtttgat cattcaccgc 3539401 gatgatagca ttcaatgaga tcagcggttt tttgacttct tttaccgaca gtttttgatc 3539461 agacagctcc cctttttggt tcagcagctt cagctgatcc ggcgcttcgt ttttgaaatt 3539521 gcggtcatac gttcccggga aatagacagc ctcgtcttct ttcaggccgt tcactttgac 3539581 atggaagtat tttgccgcat ccgattcact gatcatgtaa acagggggaa cagtttctcc 3539641 ttcctgatag cgaacatagg aaacatctat tttgtctttc gtatacgtaa aaccgtgtgt 3539701 tttcagttca tggtcaatat ctttcaaatg agtctgttct tttggattgt tgctgtaaga 3539761 taaatactcc atttcataag cggactcttc cgctccgacg gtcgatttgt acattgcgag 3539821 cacgcctgtc gcagtaaacg caaccgcgga aataatgctg acaataaaga acaggcgggc 3539881 gttgtctttt agacgataga caaggtcaga aacccaaatg atgtttttcc cgcgcagata 3539941 aaaggttttc cacttcttca gcgcgcgcag aatccatatg ctgctttggc tgaaaaagaa 3540001 atatgttccg ataacggtga gcagtaaaat gataaacggt tcggccccgt ggacattgcc 3540061 tttaagaacc atgccgtacc cgccgcacag acaggcgatg ccgaataagg acagaagcac 3540121 ggacggctta ggctccggtt taaccttgcc agtgcccttt attaatttga taaccgtatt 3540181 tgatctgaca aaaaggatcg taaactgcga taaaaagaaa aataagagca gaaatccgca 3540241 ggccgtaata ccgagcgctt tccaaggcat atacaaaggc agcgcgtcca tttctaaaat 3540301 ataagcgccg accgtaaaga acgtctttga aaaaatgaat cctccgataa taccggctgc 3540361 aattgacatg acgccgatga tcatattttc cgcagtaatg agctttctca gctgccccgg 3540421 cgtgatgccc tgcatgagca gaatgccgaa ttctttattt ctcgatttca aaaatgcatt 3540481 aaccgaatac agaacaaata agaaagaaaa aacaaagatc atccattccg cggcggttaa 3540541 gccttttttg gcgatgttat tcaggtagcc ttcctttaat gccggatgaa acaggaacat 3540601 cgcaaaggta aagaaaatca aaacggaaaa ggcgctgctt aaaaagaatg caagataggc 3540661 ccttttgttt ctcgtgacgt ttttataagc gaactgaaga aaggtcattt gcgtttcccc 3540721 ccagcataga cagcacatcg agaatttgtt cataaaatac ttggcggttt tccccgcggt 3540781 aaatctcatt aaacagttcg ccgtctttta taaagatgac gcggcggcag tagcttgccg 3540841 aaaccggatc gtgggtcacc atcaaagccg tgacatgatc atcccgattc aggctctgca 3540901 acgtttccat gacgtctttt gtcgctttgg aatcaaggtt tccagttggt tcatcggcca 3540961 gaatgagtga cggcttatga atgaccgctc ttgcgatggc ggcccgctgg cgctggcctc 3541021 cggatacttc aaacgtccgc ttgttaagca ggttttcgat accgagcttt gccgcgatgc 3541081 cgtgcagttt ttcttccatt acagacggcg cttctttttc aagcgttaac ggcagcatga 3541141 tattttcacc gatcgtcagc gtatccagaa ggttgaaatc ctgaaacaca aatccgagct 3541201 gcttgcggcg gaaatgagcg agctttgtcc gcttcaggcg atgcgggttt tctccgttaa 3541261 tcaggatatc gcctgaatct ggacggtcaa tcgttgaaat gatattcaaa agcgttgttt 3541321 ttccggaccc ggacggcccc atcaccgccg tgaactcgcc ttcttctatt gaaaatgaaa 3541381 tttgctttaa ggcctgatag gacacttgtc ctttataggt tttatttata tgtttgactt 3541441 caagcatatt cgccatgaaa atcctcctta tggttttatt cttgttgatc tgggctgctt 3541501 tcatgtagtg ccgggacgtt caacataaaa atccccttga cataaatcca tgttatcaag 3541561 gggaaacaaa gcgggctatg ttgttttctt aacgcagcct tacatttttg taagaaatga 3541621 aaatcgaact gatgtccctt caccgggaga cgagctgatg tccaccgtat gattgagctt 3541681 atctgtaatt tctttgacga gatggaggcc gattcccgta gattcttgga aacgccgccc 3541741 gttttcaccc gtgtaataag ggtcaaacac ccgcttgatg tcttgtgagg gaatcccgac 3541801 accgtaatct ttgacttcaa gcaccgtcct gtcttcatcg cagaagacat tcagctcaag 3541861 tctgtcactc ttgcccgctg aatacttgac cgcatttgtg accacttggc caatcgcaaa 3541921 tttgagccat ttggcatcgg tgtaaatctg atgatcatcg caaacgttca ttttcggata 3541981 aacgcgatat tgaataaaaa atcgtttata gctttgaata actgattgga gaagctcgga 3542041 cagggaaacc gcttcgattt taaaatcccg ttcaaacagg tcgagccttg aagaataaag 3542101 aagcgtctcc agcccgaatt caatctgccg gacttctttt ttgatttgtt caaaaacggg 3542161 ctcatcctct tcttgaatga ttaaattaat gaccgacagc ggcgtcttta cttggtgcac 3542221 ccattgattc atatacgtca cccgcgcgtc aagcttggct tcggtctcat ggagcttctg 3542281 gtgctgcagc cggatcagct ccatctgctt ttcatacagc tctgaacaga acactgaaga 3542341 accgagatac gggatatccg tcccttcctg ccccgagctg agccaatgat acacgccgcg 3542401 gtctttgtac cagcgatagg caagatagcc cgccaaaata agaagctgca cgcccaatat 3542461 gtaaaacaag tgagaaaaag aatgaagacc cgcaaaccag taataaaaga agacaaacag 3542521 cccttgaagg agaaaaagca gaatcagcac tgcatgagac cggagaaaca gcttcatgac 3542581 tgcgccctca gctggtagcc ttcgccccgc accgcttcaa tagaaacagg cgcattcagc 3542641 tcccgcagtt tttttctgag ccgcgtgata tacacgttaa gtgtattatc atcgatgaat 3542701 atgtcggtgt cccacgtctt ttccatgaga cggtcccgac tcgtcacctt ttctccccgc 3542761 tcaagcagca cttccaaaag cttgctttct tttttagaaa gctcactttt ttcatcctga 3542821 aaacgcagtt caaaccgttc cacaaagagc tgaacgccgg catattcaac cactttctct 3542881 ccctgctttg cggcgtactc cccgtacgcc ctccggatct ggcttttgat tttcgcaagc 3542941 acaatatcat aagaaaacgg tttttcgata taatcgtctc ccccattttc aatcgccatc 3543001 acctgatcca tttccccgct tctggcagaa ataaagatga tcgggcttgt ggagtgctgg 3543061 cggatctgcc ggcaccaata atatccgtca tatgccggca aattgatatc aagcagcacc 3543121 acatcgggct tttcccgcaa aaagacatca agaacagctg taaaatccgc ggcgaccact 3543181 gtttgatatc cgtatttttc aaggtaattc tgcaatagtc cgcgaatgtc ttcactgtct 3543241 tccacaatca tgattttatt caaactgaac cactcccgtt tcttacactg ctgccatcat 3543301 cataatcgtt ttgggcgtat ggacgcaaca ccgcacaaaa aaaccgccat ctcggcggtt 3543361 tctggtctct ttagccgacc tgctgcttag ctgctttacc ggctgatccg aactctctca 3543421 ttttgcttcg cactgtctct tccacggctt caatgccggg tgtcaaatag ccgcgcggtt 3543481 cgtacagatc gctgttttcc tgaaacatgc ggcgtgtttc gtctgtccac gctaccatac 3543541 attccgtatt gatattgatc ttcgcgtggc cgagcgtgat ggcttttttg atctgatcct 3543601 gcggaatccc ggatgccccg tgaagaacga ggggaatatc agtcatgcgg gagatagcct 3543661 ccatttcctt aaatccgaga ttcggctcac cctgatattt gccgtgtaca gagccgaggg 3543721 cggcggccag cgcgtcgata ttggtttctt taacgatccg ctcacattcc gtgatatccg 3543781 catagcggac cccgccgacc agtccgtctt ccattccgcc gaccgtgccg acttcggctt 3543841 ctactgacac gccgtgtttt gcggcataat cggtgacttc ttttgtcatc gcgatattct 3543901 cgtcaatcgg ctgatgggag ccgtcaatca tcactgagct gaatccggca tcaatggcct 3543961 gtctgcagcg ttccgcactg ctgccgtgat cgagatgaag cacgaccgga acggtaatcg 3544021 ccatgtcctc tattaacgcg ccgaccatgg cggcaatcgt tttaaatccg cctaaatagt 3544081 cgaccaggcg atcggaagcc gcggcgatga ccggtgattg ctccttttgc gccgcctgca 3544141 aaatcgcctt cgtccattgc aggccgttga tattaaactg gccaattgca tattgctccc 3544201 gctttgcatc ttcaagaagc tctttcatcg atacaaaagc catattcacc cctcctttat 3544261 ccattacatg ctgaagtatt ttgatacgac atccactgtt gtttttttcg ctgtttgaat 3544321 ggcttcctca gcagtcagct tatagtattc aggccggaag agctcaaccg aaacaacatc 3544381 agagaagccg atttccttca gtgctgataa gtgggcatct aagtcaattg ccccttgtcc 3544441 cggccataca cgatcctcat ctgttaaaaa gccgattggg aaatcttctg tatcatcaat 3544501 atgatagatg aagattttct ttccgtccgc ctgctttaag ctctcaatat ttgaacccat 3544561 tgcatggaag tgaaaactgt caaggacaag cccgacattg tcacggttaa ctgtgtttac 3544621 aatctcatac gcctgttcaa acgtattgac cgtacattgc ggatggccga caaactcaag 3544681 cgcgattttt acgccgtacg gctccgcgat atctgacagc tcagtcagca cgtctacact 3544741 gctctttttg atctcttctt ttacaatctt ctgctctgtc acaagcggaa cggccaccac 3544801 atatttcaca ccgagggttt tgcatgtttc catcatgcct ttaaattcag tgatgatctc 3544861 gttgtgaccc ttttcatcac ggttgttgaa gaaaacgagt gcgtttaagg caagcggttt 3544921 gatgtggtgg gtttgaaaat attccgcaag gtcatccaat gaatgatctt ttaagtactc 3544981 cggcagctta tccatagtac ggatttcaat ataatcatag ccatgctttt cgcatagttc 3545041 taaatccagt ttaaggtttg agttttccaa tgttgtcgct tcattaaaac aaagtttcat 3545101 gccagactcc cccatctgcg ttttagatat gaagggagtt cggcaggaag gctgtcgcca 3545161 tatcccgccg aactccatgc tcagcttatg ccagacctaa ttcttctttc attttcttaa 3545221 gcataaatcg gcttgattca tccgctcttt catcgaccca agcaaatacg gcattcgtcg 3545281 caattccgtc gaacttcatc tctctcagtt ttctgaaaat cgtatcaaaa tcaacctcgc 3545341 cttggccaat gtccaaatgc tggtgaaccg ttactttcgc gtcaggcgga ttgacgatgt 3545401 agcgaaggcc atgagccgct ttatgattat aggtatctgc aaataaaaca tgtgtgaggc 3545461 ggtcgccggc ttcgtcaaac atggtctcga tgtcgccttt gccgtcatca tagaagaacg 3545521 tatgcgcagt cgagtagaca agattgatcc aatccttgtc aagcgcgcgg atcatatcca 3545581 tcgcaccttt gtgcgtttcg ataaaatcat atggatgggc ttgaagattg agtttaatgc 3545641 cttctttttc aaagactggc agaagctcat ccatggattt gataaatttt tcttcacttg 3545701 ttaaaggatc atattttgaa ccgctgaatt cgctgttcat caaatccact tcaagttcaa 3545761 ccgcaatttc gattgcccgt ttccagttgc gcactgctgc ctggcggcgg tcttcatcgg 3545821 gtcccgccca gtggtaaaga ggaagaagcg atgaaagctt aacacctgta tctcttaaaa 3545881 ggcgctttaa ttgtttgatc tttgctgaat cgactttcgg atatttataa aacgggcaaa 3545941 aatcctcgcg cggcgataat tcgatatatt catagccgag ctctgccgtt ttatagacca 3546001 tttcctctaa agttaaatca tcacgataca tggatggatc caatgctaac ttcatatttt 3546061 cactcctctg ttttttagtt ttgaactgtt gtaaaagatt gatagaattc cggtttttcc 3546121 ttcaattcaa ccttttcttt ttgtccagat tcctgggctt ttacacacgc gtcagtcgtg 3546181 acagcagcaa tatagccgtc ccatgccgtc ggtccgctga cctcgccttt cttttgaatc 3546241 gaatcaataa agtcttggat ttccacatca tacgcagcga caaagcgtct ctgccaatcc 3546301 atcaaaatat cagtgctgaa tctgccttct tttctcaagc tgatgcttga tggctcggga 3546361 agcttgatga tgccgtcttc tccgacgatt tcacattgaa tgtcatagcc gtatttacag 3546421 ttcacataga tttcagcatt gatgacgata ccgccttttg tttcaatcac gacgatttgc 3546481 ggatctttta aatgtggaag cgcgtttttt gattttttcg gatagatgac ttgaacggac 3546541 tcgtagtcat cattgacgag ccagtggagc acgtcaattt catgaacaag cgtgtcgact 3546601 acagccatat ccgttgtata gttatctcct acagtcgggt tgcggtgcgc gcagtgaatc 3546661 ataagaggct cgccgatgac atgattatcg agcgcttctt tcagctgtac gtaaccgctg 3546721 tcataacggc gcatgaagcc gacttgaaca aggcgtttgc ccactttgat ttcttcttcg 3546781 acaatgcgca tgcatccttc agccgttgtc gcgagcggtt tttcacagaa cacatatttc 3546841 tgggctttaa tcgctttcag cacgcttgac tcatgcgcag gcccccagct tgtcactaaa 3546901 acagcgtcta cattttcgtc tgcaagcaag ctgtcatcat tcggataaac cgtcgcgttt 3546961 aattggtatt gctcaacgac cttttgtgca gcttcttgat taacatccgt tacagctaca 3547021 atttccgcgc ctgacagctt gttcgtgata cggttaatat gttcttttcc gattgctcca 3547081 gttccaatta cgccaatacg taaactcatt gacagccact ccttctgttg gttacatgat 3547141 tttgctttct gttcctttct ttacttggct ctgaggagac ccgtagagtt cctcttgaat 3547201 ttgttcaagc gacttgccag acgtattcgg cgcaaagagc agcccgatga tcatactggc 3547261 cgtcacacat ccgagaagaa ttgcagccat cgttccaatg ccgaaattgg tgataatcat 3547321 tgggacaaac agactccaaa tccctattga aatacggaca aggaaaaaca tcagtccttg 3547381 tgcggaagca cgatattgcg taggaaagat ttcgctggcc cataactgat agttcgcttg 3547441 ctgcccggct ccgttattga tgccgatcac gacaataaac aggagcagaa tcggcaggcc 3547501 ttcaactggc agcagaaaca gtgtccaccc gatcaccgcc atgaaagcgg cgattccaaa 3547561 tacggttttt ctatatttgt cggcaaaggg catgaagatc aaggcgaccc ccaatcctgt 3547621 gaagataaac agccccattt gcaaaaggtt ggccatgttg gcagatacac cgccgacctg 3547681 ctgataaatg tatggcataa agaagcccat gaccccggcg gctaggttcc aaaccaagta 3547741 cacacccatc aaaaacagga tgctttttag atacataggc ttgagcaaat caaaatacga 3547801 tgtcttattc aatacagccg gcttctctgc ctgagcttcc tccggctgat tttttgtctg 3547861 ccaggcgtct gattccggaa gcctgattct caggatgtac gtaatcagcg caatcacaag 3547921 cagatgggca aatacgattt tattccccaa gagtcccaag tcaccggcca gtacggagag 3547981 gagcagtaca acgacagcgc ccgcggccca agcgacttgt gctacgccgc aatgcctggc 3548041 ccgattcttc tttggcgcat tttccgcaat aatggtccat gacgcggtta tgtcagcccc 3548101 tactgataaa ccgataatga tgtaaccgct taacaacatg gggaaattaa ccccgaacaa 3548161 aaccaaacaa atccctagtg cataaaccag catactattg gtataaacag ccttccgtcc 3548221 gactttatca gccagaaacc cgccaagcag cgcgccgaca gcggcagaaa tcgcatttgc 3548281 gctcaacgcg ccgagcagcc cgatttgcgt atcggatagc ttaaggtaac tgacccataa 3548341 tgataaaccg gcggagcctg ccacaattga accggcatca atatagttgg ccaatgctgc 3548401 cgcgattgtc cgtttattga aggctgaatc tccattggta ttgcccatat gttcattccc 3548461 cattaagcca gatccaacaa ctgctgatca atatagtttc tcgcaatcaa tgcatactcc 3548521 agcgggtttg caacatcggg gtcttgttca gcttcaatga caatccatcc ggaataactg 3548581 tgcttcaaca gcagctgata tacttctcta aagtcaatgc agccgtcacc gggaaccgta 3548641 aacatgcctt ttaaaaatga ttgccggaac gattgtcctt cgagcctgca ttgttccatg 3548701 acattcaggc gggcatcctt aaagtgcaca tgcttaatgc ggccgatatg cttctcaagc 3548761 atccccatgt aatcgccgtc agaaatatac gcatggcctg tatcatagag gaggtgtaca 3548821 tgcgcagggt ctgttcctgc catcaggcgg tccacttctt ccgctgtttg gacaccagtg 3548881 ccgagatgat gatgatagac aagcttcaag ccatgctgag cggcaatttc gccaaggtga 3548941 ttcagccctt cgcaaagccg ctcccattca tcatccgtaa agtgcggctt ctctgtgaac 3549001 acatttttct ccaagctttg cacgctgtac gtttgttcag agacaactgc gacatccgcg 3549061 tttacttgct gcaaatactc acaatgcagg gtaaatgtct ttgccgcttc accaagtccg 3549121 tcacgcaaaa taaaactgct gaaccatttt cctgcaatgc gtaagttccg aagcttcagc 3549181 tctttgttca ggatggcagg ttcggggaaa aagcccccga cctccgtgcc ttgaaaacgt 3549241 gcgacaacga tatcacttaa caaatgctga agtgtatttc ccgctccaat ttcaggcatg 3549301 tcatcattcc gccacccaat gggagcgatt ccccacagga tttcattttt gcccatctat 3549361 ggtgcctccc ctctaatact gcttcgcaga ttccagcttt ttctcttttg cttcgtatgc 3549421 tttctgaacg ctttcttgtt cagatacctc tgccaccccg acatgccacc agctgtcata 3549481 gccgtccgtc attgttttag gcagcacctt catttcaatt aatgttgata catcctgttt 3549541 cttcgcatcc tctaacgcag cttttaattc ttctactgtg tttgcacggt aggttttcgc 3549601 gccgtatccc tcagcgactt tcgcgtaatc gacattcagg atttggttgt catctgtgcg 3549661 gaactcgcaa tagtagctgc cgctgccgtg atccatttgc aggttgttga tgcatccgaa 3549721 tcctgagttg tcaaagagca gcacattgat tttcttgttg tactgaatcg ccgtgatcag 3549781 ttcagaatga agcatcagga agctgccgtc tccgacgatt gaatacactt ctctgtcagg 3549841 gtgggccagt ttaagaccga gtgtcccgga cacttcatag cccatgcaag aatatccata 3549901 ctccaggtga tacgtattcg gaacattaga atgccacaga cgctgcaaat ctcctgggag 3549961 tgagcctgct gaacagatga tgacgctgtc ttcaggaatc gtctcgttga ttgtcagcaa 3550021 tgccgttgtt tgcggaagct ccgtattcaa cgcgtcagca tattcattca ggacctcttg 3550081 agaaaagtga tttttgattt ccggatcaaa tgcttcccgc ttaaacgtca ctttgctgag 3550141 acgctcgcgt tcagctagcc attcgtcctt cagctcccgg atcgttgtgc cgaactcgct 3550201 ctcatagcct tcaagcaagc cgtgcagttt gccaagcgtc actttcgcat ccgccaccac 3550261 ttggaatgca tcaagtttat acgcctgcat tcggctgacg ttaatgttca aaaacttcgc 3550321 tttatcaaaa tcaaaagcgg tcttagagga tgtcgcaaaa tctgtatacc ttgtgccgat 3550381 gccgataatc aaatcagctt ggcgggccgc tttgtttgcc gcaagtgtac ctgtgatgcc 3550441 cattccgcca aggttgttcg caaaatctgc ctcaacggta gactttcctg cctgcgtttc 3550501 aactaacgga atgttatagg cttcagaaat ggcaaccaat tcatcgcgcg caccggaata 3550561 ttttgcgcct ccgccgacga gaatcacagg ttttttgctg gatttaatca gctccgccgc 3550621 accttgaagc tcgcgctcgc tcggctgcat gcgatcaata tagtgaaccc gtttgacgaa 3550681 gaaactttca tcaaaatcgt atgcttcccc ttcaacatcc tgagaaatac aaatcgttgc 3550741 cggacctgct tttgccggat cagtcatgac ttcaaacgcg cgcagcaaac tgctcatcag 3550801 ctgctcaggg cgcgtaatgc ggtcccagta tctcgataca ggcttcaatg catcgtttgt 3550861 cgtaatcgcc gcactgtatt cttgctccat ttgctgcagt acagggtctg gctgtcttgt 3550921 cgcaaatgtg tctgccggaa tcaagagaac tgggatatta tttgccaatg cagtgccggc 3550981 tgccgccacc aagttagccg ctccaggtcc gacggatgta gacaccgcat atatttttct 3551041 tctcagcatt tgcttgctgt acgccatggc cgcatgcgcc attccttgtt catttttccc 3551101 ttgatagact ttcaaatggc ctgcatcctg ctcaagcgcc tgcccgatcc ctaatacgtt 3551161 tccatgaccg aaaatcgtga agatcccttc gacaaaaggc tcttcctttc catctacatg 3551221 gatgtactgc tggtttaaga atttaatcag cgcctgcgca gttgttaagc gaattttctt 3551281 acccacaaac gatcccacct ttactcgatc tttttcaatt atgactgtgc ttcaataagc 3551341 tgttcgattt cttccgcagt cggcatcgct tctgacgaac tgtgcttgct caccacaatg 3551401 gaggctgaag cactgccgta tttcaatgcc gtttcaatgt cttttccgct gacaaggcca 3551461 tagataaagg ctgacgcata ggagtcaccg gccccaaagg ttttcagcac ttttgtcttg 3551521 tacgcttgag cgcggaatac ctcgccggat ttgctgtatg cgtaagagcc ttcgacgccg 3551581 tgtttgatga caacgaggtc ggctgaatgg ccaaataaat gattgacgga ttcttcattg 3551641 cttccgcctg tgcggttttc catcacatca aattcatcgc gtgtgccgat gacgatatca 3551701 gactgctcgg caaccaaaga ataataaacg gctgtttcat ctgatgactg ccacgtatat 3551761 ggccggtaat ccagttcgaa taccacctta acctgatgct ttttcgcgta ttgaacagct 3551821 tttaacaccg cttcccgtga cgggcttttg gcgagcgctg tcccggagac aagcagcatt 3551881 ttcgcatttg cgatatagtc ctcacttacc tctgaaggct caagataaag atccgccaca 3551941 tcatcgcgat acattaagat gctgcattct tcagggctga ggatttctgt aaatgcaagg 3552001 cctgctttgt gtccatcttg atcaacaatc atctgtgtag tatccacgcc ggtctttctc 3552061 atataggact ctatgaatct tccatgctgg tcatccggaa ttttgccgat gaagcccgct 3552121 tttaagccaa gcttcgcgct gccgatcgcg atattcgcag gtgaaccgcc gacatatttc 3552181 gaaaatgtca tcgtttcttc cattgggcgg ttgtattcga ctgcgttcag atcaatacat 3552241 gcccggccga tggcaacaat atcaaaagcc ttctcttcat tgaatgtata cttcatcgta 3552301 aacagccact cctcacttgt tagcgttcta aaatccattc atgcgccggg tcgttataaa 3552361 acttccattt tcgcgtcggc cctgccatga catttaaata gtaggatgtg tatccgtccg 3552421 gaacgcctac cgggtggtat cccgcaggaa cgatgacaac gttttcattt cccacagtca 3552481 ttgtctcgtc aatagaacgg tcatctgtgt atacgcgctg aaacacaaag ccctgtcccg 3552541 ggtctaactc atggtagtac gtttcttcta agaaagattc ttccggcaag ttgtcttggt 3552601 catgtttgtg aggcgggtag ctggaccagt tgccgctgtc tgtatagact tcaactacta 3552661 atagactgtt agctgaaggg tctgaatccg gaagaatgtt atgaacagta cgtttgtttg 3552721 aaaattgccc gcgatgctca attccgttgt cttccgcttt gatcagcttt gtcggaagct 3552781 gcttttccga tggagaatag caaagcgcca ctcttgcgtc gctgaccgct gtgatctcaa 3552841 atgcacggtc atttgaaata tagacgctgt ctgtcggttt tcgttcaaat acgctttcgc 3552901 gcgtgccgat attctcaaaa gtcgactcat gatctgtcac tgtaattttc cccgttaccg 3552961 ccacaataca gatttcttgt tttttcaatt cttctgtata gcttgaacct gatgcaagat 3553021 ctaacacttt aaactctaca taagtgagat cagagttgga tgtcgttact tcgtgcacga 3553081 gtttgacccc attagacact tcatgcgact gcggcttacg caacaaataa ctcatagaga 3553141 agccctcctc tttctattgg cagaatgagt ccgaacagcg cacatggacg ccgttcggct 3553201 gttcgtcgtt tagttgaaat caggtgccgg atatcttgcc gtcaccactt ttttacgtgt 3553261 atagaagtcg acgctgtctt ttccgttcgc atgcagcgtt ccaaagaatg aagatttcca 3553321 gcctgagaat gggaagaacg ccattggagc cggcacacca aggttgatgc ctagcattcc 3553381 cgcatcaatg ttttcacgga agtagcggat tgcgtttgag ttggatgtga acaagcaggc 3553441 gccgttcgca aactcagact tattggcgat ttcaatcgct tctttcaggt ttttcacacg 3553501 gatgacagat aagaccggag cgaaaatttc atctttccag atcgtcattt ctgttgtgac 3553561 attgtcaaag atcgtcgggc cgacaaagta gccgtcgtca gacacatttt cacgtccgtc 3553621 acatacgagt ctggcacctt cttcaagacc tttttcgata tagctgagcg tgcgcttctt 3553681 gttgtcttcg cgaatcaccg gtcctaagaa cacgccgtca tcaaggccgt taccgatttt 3553741 aatgtccgcc actttttcct gcagcttcgc cataaattca tcggcgattc cttcttcaac 3553801 tgtcacaacc gcacaagcca tgcagcgttc accggcagaa ccgaaggcag ctccaacgat 3553861 gtttgtaacc gtgtcttcaa gattcgcatc gttcaagaca atcgtatggt ttttcgcgcc 3553921 agtcagagat tgaacgcgtt ttaagttttc gcttcctttt ttgtagacgt attcgcctac 3553981 tggcttggag cctacaaatg aaatcgcttt aatttcggga tgctcgagga tgccgttcac 3554041 aacgtcatgc gcaccgtata cgacgttgaa cacccctttc ggaaggcccg ctttttcaaa 3554101 aagctcaacc aatttctctg ttaacagcgg agtccgctca gatggcttta aaataaatgt 3554161 gttgccgagc gcgatcgcca tcgggaacat ccagcaagga accatcatcg ggaagttgaa 3554221 tggcgcgatt ccgccgacaa ctccgattgg gtaacggtag ttcgccgctt caacgtccgt 3554281 tgcgatggaa gcaagtgagt cacccatcat cagggaaggt gctccagcgg cgaactctac 3554341 gttttcaatc ccgcgtccca cttcacctaa agcttctttc gtgttttttc cgttttcaat 3554401 ggtaattaga tgagcaagtt cttctttatg ctgagacagc agctgctgga agttaaatag 3554461 aattctggcg cggcgaggaa ccgccacctt tgaccatgtt ttaaatgctt cagccgctgt 3554521 ttgcgctgcg taatcaatat cctcttttgt agaaatcggc acttggcata gcacttcttt 3554581 cgtcgccgga ttgacgacat cttcatattg atctgttttg ctttcaaccc attcaccgtt 3554641 gatgtagttt tttaattttc tgatttctgc cattcttatt gcctccttca ttagtaaaca 3554701 catacacttg tatggatggt tccggataga ttcatatcaa tatccacttt tcagcaagcc 3554761 aagaattaaa cgctttcaaa aacaccaaaa aaataaatgg cggatgcata tttacataca 3554821 agcaaccatt tcatgcacaa caggttactt tttggtcatt tcttggttat attctaatcg 3554881 cataataccc ataagtcaat cataaacact acattttttc attattttta ttatattaat 3554941 cttttaatca agtaagagaa gtaagagaag gccgtccaat cttgcaaaag atatacaccg 3555001 atgttatcat ttttaagcaa ctattgatta acttttggtt tttattatat atttatgtta 3555061 cgtaaagatt caagaaggag ttttttatat gaaactgatg cggattcagg aaatggagga 3555121 gtacatttta tcgcatggca ctgtttcctt agatgagctg tgccaggtgt tcaatgtctc 3555181 caaaaacaca gtcagacgtg atatcaacaa gctaacagaa aagggtgcga ttgaaaaagt 3555241 atacggcggc gtaacatcta ttgaaaaaac cgcattagtt ccttttgaaa atcgcaccat 3555301 tcagcaccag gatgaaaaaa caaaaatcgc ccattatgct tcccgattta ttgaagatca 3555361 cgatttggtc ttcattgatt caggaacgac gacaaagtct attcttgata cgcttgatcc 3555421 agccaaaaat gtcaccatct taaccaacag tttagacatt atcaatgcgg cgtcagcttt 3555481 gaagaatatc aacttaatca ttatcggaaa caactataag agaaaaaccc gctcctttgt 3555541 cggcatggac gacccggcta tgcttgataa gtacaatatc aacaaagcct ttatgtccgc 3555601 taccggaacg acgctgactc acggattgac caattcggat ctgctggagt atgaaattaa 3555661 aaagaggatt tcagaaaaag caaaagaagt gtatctattg gctgaccatt ctaaattcgg 3555721 aaaatcaacg cttctgacgt atgcaccgtt tgacaggctg cattgcattg tgacctctca 3555781 gccattagac gacgagtaca cgcagtactg caatgagcat caaatcggca ttcatctggc 3555841 ctaacgttta caatagtgtt gagagtctat catccatttt attctaggag gcagatcatg 3555901 aaaaaagcga agctcggaaa atcagacttg caggtattcc ctatcggatt aggaacaaat 3555961 gctgtcggag gacataacct ctacccgaac ctaaatgaag aaaccggaaa agaattggtg 3556021 cgcgaggcga tccgtaatgg cgtgacaatg ttagacaccg cttacattta cgggatcggc 3556081 cgttccgaag aattaattgg tgaagtgctg cgtgaattca accgtgaaga tgttgtcatc 3556141 gcgacaaaag ccgctcacag aaaacaaggc aatgactttg tctttgataa ttcaccagat 3556201 tttcttaaaa aatcagttga tgaaagcctg aagcgcttga ataccgatta tattgatttg 3556261 ttctacattc acttccctga cgaacatacg cctaaggatg aagccgttaa cgcgctgaat 3556321 gagatgaaga aagccggaaa aatccgttcc atcggtgtat ccaacttctc tttagagcaa 3556381 ttgaaagaag caaacaaaga cggtttggta gatgtattgc aaggcgaata caacctgtta 3556441 aaccgtgaag cggaaaaaac attcttcccg tatacgaagg agcataatat ttcatttatc 3556501 ccttacttcc ctctcgtatc aggtttattg gcaggaaagt atacagaaga tacaacgttc 3556561 ccagaaggcg acctgcgaaa cgaacaggaa cacttcaagg gtgagcgttt caaagaaaat 3556621 atcagaaagg tcaacaagct tgcgccgatt gccgaaaaac acaacgtgga tatccctcac 3556681 atcgtattgg cctggtattt agcaagaccg gaaattgata ttttaatccc aggagcaaaa 3556741 cgtgccgatc agctgattga taacatcaaa acagctgacg tgacgctttc tcaagaggat 3556801 atttcattta ttgataagct gttcgcataa gaagaaaaca gccttctcca atggagaagg 3556861 ctgttttttt gtgcgataaa ttcctaaata actgattttg aagcaaaacc ttacaaaatg 3556921 agccataaat ccgataaaat aaaggtagtt tatctcagaa agaaagtgat tgagaaagca 3556981 aaagtatgaa acgttcatat catctagctc atatgaaata aagctgaccc agcttctttt 3557041 atttgctggt cagaatagcg gaccgtttcg atggtctatg gaggaaacag aatgaaactt 3557101 aaatatgtaa aagccttagt tgcagtaacc gttgctttag gtgtactgct gccatcaacg 3557161 atttctcatg caaagagctt tagcggccgc tcatcatcta gttacagcag ccgaagttca 3557221 agctcatcat acagcggaag ctataaatca agcccgaaat caagctacag ctcaggatca 3557281 agctcttcta gcaaaaaatc caagacgtct gacgattcat catcatcgat ttcgcttaaa 3557341 aagaagcctt cggaaaaggc aagttcatca agctctaaaa aatcgtcagg caccttttcc 3557401 ggcgctacat caaaagtaac cggaaagaca tacagcggaa aaacgtctaa agcctatgtt 3557461 ggcggacgtt atgtttcagt caatcattac tatcacgcag gtttcgcgcc atcaggatgg 3557521 tttggatatt atagcggatt tacaatgggt atgttcatga tcagcatgat gcacccatgg 3557581 ggttacacct atcatccagt cggaggcccc ggttatgttt cttatggcgc ttcacccatt 3557641 gcctggatcg ttgatatcat cgctttgatt attattttaa tcattgtcat cgcattgatt 3557701 cgcgcattta aagcaccgaa gacgtacaga aggagatttt aggcaatgag attaatatta 3557761 aatgagcaag aaattgtaga cggaatttgc gtgtatattt ccaatgaaga agatatctac 3557821 cctgaagacg ttgaagtaaa agaactatcg tacaacaagc gtacagggtt cttcgctgaa 3557881 gctacatttg gcctgcacca caagcagctt atgtcagatg acatttcaga aggcattatt 3557941 cagttcttag aggaatacca caacttcaat ccggacgtta ccgtcgttga attgcaattt 3558001 gataagaaaa aaggcttctc cgccttggtt tttgtcaacg aagcagaaga ataaaaatgt 3558061 cttaatcaaa ccttactccg cgcgggtaag gtttttttaa tggtttctct gagcataaag 3558121 ttatttcgtt tttcctaaac tcagcggatc tgtgatcatc tcttttggct ataaagtttc 3558181 cgttttttca aaacaaatgt ttcaaatgag ataggaaatg ggtactaatc tattaacttt 3558241 gttacatatt tttagatact cattggctca acaactgagg aggagacatt tgtgaagaaa 3558301 gacacaagga aatatatgat ctactttttc ggcgctttag ggggactgct atatggttac 3558361 gatacaggtg ttatctccgg agcactcctg tttatcaata acgatattcc tttaacgaca 3558421 ttgacagaag gattggttgt cagcatgctg ctccttggcg cgattttcgg ttctgccttg 3558481 agcggcacat gctcagaccg ctggggcagg agaaaggttg tatttgtcct ttccatcatt 3558541 tttattatcg gtgcgctcgc ttgcgcattt tctcaaacaa tcggcatgct gattgcatct 3558601 agggtgatac tcgggttggc cgtcggcggt tcaacggcac ttgtgcccgt gtatctttcc 3558661 gaaatggcac cgacgaaaat tcgcgggaca ctcggcacaa tgaacaactt aatgattgtc 3558721 accgggattt tgctcgccta tatcgttaac tacctgttca caccgtttga agcgtggcgc 3558781 tggatggtcg gtctggctgc agtgcctgcc gtgcttctat taatcggcat cgccttcatg 3558841 ccggaatcgc caagatggct cgtgaagcgc ggcagcgaag aagaagcgag acgcatcatg 3558901 aacatcactc atgaccccaa agacatcgaa atggaattgg cagagatgaa gcaaggggaa 3558961 gcggagaaaa aagaaacgac acttggcgtg ctgaaagcca agtggattcg ccctatgctt 3559021 ctgattggcg tcggccttgc cattttccag caggcagtcg gcattaacac ggtcatctac 3559081 tacgcgccaa ccatttttac gaaggccggt cttggcacat cagcttcggc gctcggcaca 3559141 atgggaatcg gcatcctcaa cgtcatcatg tgtatcactg ccatgatctt aattgaccgt 3559201 gtcggccgca aaaaacttct gatctgggga agtgtcggca tcacactgag ccttgctgct 3559261 ttatcaggcg tgctcctgac actggggctt tccgcatcaa cagcgtggat gacagtagtc 3559321 tttctcggtg tctatatcgt cttttaccag gcgacatggg gtccggtagt gtgggtgctc 3559381 atgcctgagc tcttcccgtc caaagcacgc ggagccgcga cagggttcac gactttggtg 3559441 ttatcggcgg ctaacctgat cgtgtcgctt gtcttcccgc tgatgctaag cgcgatgggc 3559501 atcgcatggg tctttatggt tttctcagtc atttgtcttc tctcattttt cttcgcgttc 3559561 tacatggtac cggaaaccaa agggaaaagc ttggaggaaa ttgaagcaag cctgaaaaaa 3559621 cggtttaaaa agaagaaaag cacccaaaac caagtgctga atgagcgtac attataaaaa 3559681 aaggaatcgt ctccttatga gacgattcct ttttctgttt acaccatgac cttgcaaata 3559741 ttgttcgtaa attccacagg gtcctgaatc ggcaggcctt cgatgaggag cgcctgattg 3559801 tacagaaggt ttgtgtacag gctcagcttc tctttatctt gttcaaacgc gtcctgcagt 3559861 gtttggaata cctcgtgatt tgggttgatt tccagcactt tttccgcctt cacattttgg 3559921 ctgtcaggca tcgcatttaa gattttttcc atctcaattg tcacttcgcc gtcagcagca 3559981 aggcagactg gatgtgattt aagccgtttt gagattctga cgtttttcac tttgtctgac 3560041 agaatgtttt tcatttcctc aaacagatcc ttatacttgc tttcctcttc ctcggactgc 3560101 ttttgatcct catccgtgtc tatgccaagg tctccgcttg atacggactt gaattctttt 3560161 tcctgataag aagccagcat tttaattgca aactcatcga tgtcctcagt aaagtagagg 3560221 atttcatagc ctttgtccgc caccatttcc gtttgcggca gtttctcaat gcggtcgtaa 3560281 gaatcaccgg tcgcgtaata aatgaatttc tgctcctctg gcattctgga aacatactcg 3560341 tctaagctga ccagtttttt ctcttttgaa gagtagaata agaggagatc cttcaattga 3560401 tccttattcg cgccaaaatc attgtacacg ccgaatttca gctgtctgcc gaacgacttg 3560461 tagaacgtct cgtatttctc gcggtctttt ttcaacaggc tttgcagctc gcttttgatt 3560521 ttcttgctga tgtttttcgc gatcagcttc agctggcggt catgctgcag catttctctg 3560581 gaaatattca gcgacagatc ctcagaatcg accatgccct tcacaaagct gaagtggtcc 3560641 ggtagcaggt ctgcgcactt attcatgatc agcacgccat tggaatacag ctccaagcct 3560701 ttctcatatt ccttggaata gtagtcaaac ggcatgtttt cagggacgaa tagaatcgcg 3560761 ttgtagcgaa ccgctccatc cacgctgata tgaacgtgtg tcagcggttt atcaaacccg 3560821 taatgctttt cagcatagaa tttttcataa tcctcatctg tcagctcgct tttgtttttt 3560881 ctccagatcg gcaccatgct gttgaccgtc tgctcttcct gcacctcttc aaattcattt 3560941 tcgctgcctt ccttcggctt attaatggtt gtatccattt tgatcgggta gcgaatgaag 3561001 tcggagtact tcttgatgat cgcttttaaa cgatattcct ctaaaaactc gtcatagctg 3561061 tcatcttctg tgttctcttt gattttcagg ataatgtctg taccgacaga atccttttca 3561121 cacggctcaa tcgtatagcc gtctgcaccc gcagactccc atttataagc ctcttcgctg 3561181 ccaagcgctt tactgatgac tgtcacgaca tcggcaacca taaatgccgc gtaaaaaccg 3561241 acaccgaact gcccgataat gtcatgtccg tctttcagct cgttttcctt tttaaacgcg 3561301 agggaaccgc tttttgcaat tgttccaaga tgctgttcaa gctcatcctt tgtcattccg 3561361 atccccgtat cagagatggt taatgttctc gcatctttgt cagctgcgac ctttatgtag 3561421 taactgtctt tatcaaacgt aagcgcatcg tccgtaagcg ctttgtaata gattttgtca 3561481 atcgcatcac tcgaattgga gattaactcg cgcaggaaaa tttctttttg ggtataaatg 3561541 gagttaatca tcatatccag caagcgttta gactctgctt taaactcttt tttcgccact 3561601 cttgatcgct cctttaccat tatgtaaacc cttttcagca tctatttatc acataagatg 3561661 acaattgtca attagattga tagatgcata tatatgtaaa tttaacatta gttggatttg 3561721 ttttcactct ttttctcact cattctcata aaaaagagag gcttcatcat cctctctttt 3561781 tttctgtgtc attccaacgg ccaaactccc gcttcatcca tatatgcacc gggtagaaaa 3561841 acaaaccgaa cggtatcaaa aacaaaagat tatgccatga agcattcaga aatgcgcttg 3561901 cagtcaccgg gaacgtaatc tcttgcaata aaaaagagat gacagtcagc acaacaaatg 3561961 cagatggaat ggtcacgatg caataaaact tgagctcctt cttatgctgt accttcaaac 3562021 atacaaacct cccaacaatt tctaattcat cttaacatat gctggccttt cttttctcgc 3562081 atgtttatca ctgcacatag cgggaagaca aatagaaaaa ggaggtctcg tatcatggga 3562141 agacttgaaa acaaaacagc agttatcaca ggcgccgcga caggcattgg tcaagcgacg 3562201 gcggaggttt ttgccaatga aggcgcgcgt gtgatcatcg gagatatcaa taaagatcaa 3562261 atggaagaaa cagttgacgc aatcagaaaa aacggaggac aggccgaatc ctttcacctc 3562321 gatgtgtcag atgaaaacag tgtgaaagca tttgctgatc aaatcaagga tgcatgcgga 3562381 acgattgata ttctgtttaa taatgccggc gttgatcagg aaggcggaaa ggtgcacgaa 3562441 tatccggttg acctgtttga ccgcattatc gccgtcgacc tgcgcggcac attcctttgc 3562501 agcaaatatt tgattccgct catgctcgaa aatggaggct ccatcatcaa cacctcctcc 3562561 atgtcaggcc gtgccgcgga ccttgaccgc tccggctaca acgccgcaaa aggcggtatc 3562621 accaacctga caaaggcaat ggcaatcgac tacgcacgaa acggcatccg cgtcaattcc 3562681 atttcaccgg gcacgatcga aacaccgctg attgacaaat tagcaggcac aaaagaacag 3562741 gaaatgggcg aacaattccg cgaagccaac aaatggatca cgccgctcgg acgtcttggc 3562801 cagcccaaag aaatggcaac agtggcactg ttcctcgcat cagacgacag ctcatacgtc 3562861 acaggagaag acatcaccgc agacggcggc atcatggcgt acacatggcc tgggaagatg 3562921 ctgattgagg agaaatggaa ggaagaaacg aaataagaga gggagccccc tctctttttg 3562981 tcttttaaag caatacaacc ttatatttct tcacatccaa aaactgcaaa aactccctcg 3563041 ccagcacttc aggcggatgc gcctttcctt catccagccg atacaaaagc aacccgataa 3563101 tcattgcgga tacataatgg gcataaagct ttttctctgc gtgaatatca gtttgctgat 3563161 gcagataaaa cgattccagc gctttgaaca tatcaggtat cacatgagga acaccccatt 3563221 cccgattgag aaaatggaca atgggcatgt ttgacaaagc agaaagcaga atggcgagcg 3563281 ccttctccgc ttcctttaag gaaaattcat tcgggctgga ggcaatcgtc aggtgatcaa 3563341 tgatctccgc acatgatcgc tgtatcatgg tttggagcaa ttcctcctta ttggcatagt 3563401 gatcataaaa ggttgcacgg cggatattgc ttttacgcgt aatatctgaa atcgtgatgc 3563461 ccgcgtagtc ttgtttctcc gccaatacat ccagaaatgc cttctgcagc gcctctctcg 3563521 ttcgaaccac ccgcctgtcg atttgcttct ccttctctcg ctctcctggc acagcttttc 3563581 caaacagcca ataaaaccgc ttttgagaaa caagctccca taccttctgg ctgatggctt 3563641 caggagacgc ggccgcatcc tcattcagcc aatacaggat aatcgcgtac gtgtacaagg 3563701 cccgataatg tccataaatg tcccgttcaa tcggcgttaa attcacatgg atcggagcca 3563761 gcagcacatc ctgctgaaac acatccttaa aaaaacgatg aaaatgtcct ctgttcatca 3563821 tcacagaaaa aaaggaacga tgctcatgaa caaaggacag cgtcggatgc accgtttgcc 3563881 gttttttgtt caaatgaagg gtatccatat gactgaaggc gtcaaaaagc gctttgccca 3563941 gtccttcctt catgtcttcg atcacatcct caatgattga aaacttatcc tcataataaa 3564001 ggtagagcga tccgcggctc actttggcct tctcagcgat ttctttcatt gtgatgtgtt 3564061 gaatatctct atctttcaat aaagccagca gcgcctcttt cacttgagct tcggcagatt 3564121 ccggcacaaa agacacctcc aatcattaga cagatcttag atatatgtac ggtaacgtat 3564181 agatggttca ccgttgtctt tcttacagaa aaggtaccac cttataatag gtccgagaaa 3564241 agaagaaagc aaatgagggg gattttacaa tggaacagca agtaaaggac gacatccagc 3564301 gtgtctttca gcttcagaaa aaacagcaaa aagccttgcg cgcttcaaca gcggaacagc 3564361 ggagagaaaa gcttcaacgc tttttagatt ccgtcatcgc ccatgaagaa gaaatcatcg 3564421 aagcgatccg caaagacgtc cgcaaaccat atcacgaagt caaaaaagcg gaaatcgaag 3564481 gaacaaaaaa agcgattaga gataatatga ataacctgga acaatggatg gcgcctaaag 3564541 aagtcggttc atcgttaagc cctgacgcaa acggaattct tatgtacgag cctaaaggcg 3564601 tcacactcat cctcggcccg tggaactatc cgtttatgct gacgatggcg ccgcttgccg 3564661 cttctctcgc agccggaaac agcgcgattg tgaagctgtc cgatttcacg atgaacacga 3564721 gcaacattgc tgctaaagta ataagagacg cttttgatga aaaagaagtc gcgatttttg 3564781 aaggagaggt tgaggtggca accgaactac ttgatcagcc gttcgaccat attttcttca 3564841 ctggaagcac aaatgtcggg aaaattgtca tgacagcggc tgccaaacac ttggcatctg 3564901 tcacacttga gcttggcggc aagagcccga cgatcattga cagtgaatac gatctgatgg 3564961 acgcagcgaa aaagatcgcc gtcgggaaat tcgtaaacgc cggccaaacc tgcatcgcac 3565021 ctgattacct gttcattaaa aaagacgttc aggacaggtt cgcggggatt ttacaaacag 3565081 tcgtcaacgc tggatttatg gaggatgatc ataccccaga ccgcagcaaa tttacgcaga 3565141 tcgtcaatga ccgcaacttc aaccgcgtca aagatctgtt cgacgatgcc atcgaaagag 3565201 gggcggaagt ggtgttcggc ggcgtattcg atgccagcga ccgcacgatc tcgccaaccg 3565261 ttttgaaaaa cgtcacgcct gacatgaaaa tcatgcagga ggaaatcttc gcatcgatcc 3565321 tgccaatgat gaactatgaa gacatcgacg aggtcatcga ttacgtaaat gaccgcgata 3565381 aaccgcttgc actttatgtg ttcagcaaaa accaagatct gattgacaac gtccttcagc 3565441 acacgacatc aggaaatgcc gccatcaatg atgtcgtcgt ccatttcagt gacgtcaacc 3565501 tgccattcgg cggcgtcaac acaagcggaa tcggctccta tcatggggta tacggattca 3565561 aagagttttc tcatgagaag ggtgtattta ttcaggccgc tgaataatcg catgatcaaa 3565621 aggcgcttcc ttagaggagc gccttttatt gtaactcctt gaccaaaagc aattcatcac 3565681 ggataggtat tttattatct gccagtaaag gaatttcggg cttcatcttt ctggccgtct 3565741 cgactgcatt cacaaatagt cgatccaacc ggtaccctct cttctgataa aacgctaatg 3565801 catgaatatt atcattggtt gtgatcagtt ttatttgttt gatatttctc tctctgcatg 3565861 cttcctcggc tttctctagc agagctgttc cgatcccttt attctcaatg acactatcca 3565921 gcgaaatgat ttcacaggca tcttcttcaa atatgtatgt aataaggcca acaatctggt 3565981 tatcatcgtt gagcattcca taaccatcta attcatcgca gttataaata ccgctagaaa 3566041 taaccatttg cggactgccc cagtgttttt gaaaaaacgc ggaaacaaga tctttaggta 3566101 cctggcatgt cggaataata ttcatatttt cctcctttta gctgaacaaa aataagagaa 3566161 ttaacaacct attttatgtc attaatcccc ttatctagta tttactagaa cttataactt 3566221 gtcaaaagct gtctgaatac caattgcgtg gattgataag gatcaaaatc tgaatcctga 3566281 gattggaaga tttgctctgg ggtcaatgtc tctgcgttct ctgataacgt ttgaatcaga 3566341 ctttccaaat atccatttaa ctctgatttg gacgattcat gtagggattg atgatttaca 3566401 gcgagttctc taaatctgtt atcactgatt aatttttttc gaagagctgc tagcatcaag 3566461 tcaagccatg caggctggcc aaatgtaata tttaaagcta acgttgcttg atcagatttg 3566521 gtggagtgcc ataaacctct tggcaaatac agcatggttc ccggtgttaa attaacgatt 3566581 tctgcatctg gcagatcctc ttttggcgga tctcctttcc aatatgactg taaatcatca 3566641 ggatagtaag gagcctctga taaatcatag tgctgcattg gattgctcac attttcattc 3566701 ttggcaagct tccatgtttt ctcaccttga atttgaaaaa tcaagttggt gtaggcgtca 3566761 aaatgggctt tgaatccccc gccatttttc gccgcgtaaa caatggcttt ggaagaagta 3566821 cccgcaggca gtcttaattc cgctttgagt ttttctatcc accttctgac ttggggaata 3566881 aataggtcgg tgaaatcaaa ctctaatgca gccccttttt cataccactc taaagcctct 3566941 gcaggtgaca caagaaatct gtctgtgatc ccttcagatt cttcaatcac agcatcacca 3567001 acgaccatga ctggattatt gtagatagcc aatacgtttt ctagcgttct aaccttttca 3567061 aaccccggta tgcttgtaaa tctctccact tctcctctgg ctaccaaagg ttttacaggc 3567121 caatattctt ctaaaaactc actcatcgtt acaggactga tgatagactc caaaaccgat 3567181 tcggttacag cactcatatt atccctccca aaaaaagtaa cttcaccaca aagatataac 3567241 atttttttct aaaagtaaat attgacagaa ttatcagagg attataatat ttagttgtgc 3567301 gtgatagcct atttttttac aaggaaggag ggaaaaggat gaaaaaggct tataagaaac 3567361 ctcgtctttt tgaactgcgc cgtgctgtag cagctggcgg ccattaatct catatagcat 3567421 ttgacatcta gtactctatt ttaggaggga tgctcaatga aaaaagctta taagaaacct 3567481 cgcctttttg aactgcgccg tgctgtagca gctggcggcc attaatctca tatagcattt 3567541 gacatctagt actctatttt aggagggatg ctcaatgaaa aaagcttata agaaacctcg 3567601 cctttttgaa ttgcgccgcg ctgtagcagc tggcggtcat taatcttatc caaaacgatt 3567661 aacgtttgag gctatcacgc caacttgata aggaggatgc tgaagatgat tacggctgaa 3567721 gaatgcagaa cgtacaaaga atttgttgat ctttaccaat cctatcttta ccccttgctt 3567781 ggcgccagac tgtcccggat gtattccccc aaaaacaaag tcattatcga tatgggcaca 3567841 ggtccaggtt atttaagcat tcagttggct aaaagaacaa atgcgcacgt gcatgctgtc 3567901 gatattaacc cggccatgca tgaaatcgct caagaagaag ctaaaaaaag cggagtaagc 3567961 agcctgattt catttgattt ggaagatgtc caccatttat cttacgctga ccaatatgct 3568021 gacttcatcg tctcctactc ttgcctgcat cattgggaag acgttgttaa aggacttaaa 3568081 gagtgctata gagttctggc tccgggcgga aaaattgtca ttttggatac atttaatccc 3568141 caaggaagcc atttagagat tatgcgaaaa caaatcaaag aaccggaata cttcaggttt 3568201 gtaagagagg catttgaaga aagttattcc tttgaagaca ttcaccagtt tgttcaggat 3568261 gccggcattc ccaattattc attagaaacc tttcactttt taccggagga ttttatagaa 3568321 agcttagatg agctggagga tgctcccctg tgggaacaaa atgatcaaag tactgatcat 3568381 gaaattgagt ctgtcacatg gatgttaacg atagaaaaag aaaaggaagg tgcattgtaa 3568441 tgatcaatga atcaactgtt ttatccaaaa atccagaaat gccatcaaga aaatatttga 3568501 aaagcattat tatagagccg ggcatcactt taaatgaaat ggcatcagat atttataacc 3568561 atatcgacgg caaggtcagc atacatgata tttgctcaaa aatcgtcaat gaatatgatg 3568621 ttgattatca aacctgctta gaagattgta tggagctgtt tgagttgctt attgatcatg 3568681 aagcaatcaa agttaagcag ggggcatgag aattggaaaa acaaaaagtg cttgctttac 3568741 cagacgatgt acatgagctg agtacacacc gttctaaatc aatcgtaaat tacatcatca 3568801 ctctgcttgc ctttgccaaa aaacaaggat tgactcatca agatattgta agctggattc 3568861 acgagcaata tgaggaaaga ggatattatg atgagtggag acacattaac agccaacaac 3568921 cagttggatc atttgtggaa ctctttataa aaggaagacg tttactttat gacaaaattg 3568981 aattgtttga aacagaagat aaatatgtcg taaataccca cacttggtat gaaaaagaac 3569041 ctagtgaggc ctttttttat tttgaaattg atcccgaaga attttctgcg tacgcttcca 3569101 ttctcgcaat cgaaaacgca aaacgtctcg gaattaaaat cgatattgta aaagaaacag 3569161 atgtagagac agcttatatc tataaacatc aataacgcta ttgggaggga gacatatgtg 3569221 cgggctcgcg ggtattataa atctggctgc tccccgttct caggaatgta cctttcatat 3569281 attgaaaggc atggcagatg ccatcagcta taggggaccg gatgatgaac aatatcatat 3569341 tgattccaaa gtcggctttg catttcggcg attgtccatt cttgaccttg taaatggaca 3569401 gcagcccttt ttaaatgagg atggatcaat cgtcgttatg gtaaatggag aaatttataa 3569461 ctataaagaa ctgaaggctt ctttacacaa tcatatgttt aaaacgacat ctgattgtga 3569521 agtaattgtt catttatatg aagaaaaagg gattggattt gtagacgaca tcatcggaat 3569581 gttttcaata gccatttggg acaaaaataa aaacaaagta tttttagttc gtgaccgctt 3569641 tgggattaaa ccgctttttt acacagagct aaaacacgag cttatatttg cctctgaaat 3569701 aaaatcccta ttttctcatc ctcactgtcc ccgccaattt aattggaaag aagcactctc 3569761 agacatttgg ctaagcgggg aagcagccag taatcataaa gaaaccactt ccttttttgt 3569821 aaacatccaa aatctcgatg ctggccatta tctcgaaatt aatttgacaa caaatgaacg 3569881 aaaaacagca agctattggt ctttacagga tattttgctc aggcaaggct atcgtgagaa 3569941 tctccatccc gatgacctga ttgaaggata tagagaactg ctggcagatt cagtccatag 3570001 atgtttacaa agcgacgttg aagtcgggtt gtttcttagc ggtggcattg attcagctgc 3570061 agtcgcacat tttgctgcag aaaaacagga tctccatacg tttacagtat taagccaaag 3570121 tacatttaca aatgaagatg caaaatatgc ccattggctg gctaaagatt tacaccttcc 3570181 aaatcatcag gttctctatc aattagggaa cgatgagtta ttacaaccag agtcatataa 3570241 acatttgtta tggatctgtg aaacaccgtt ttgcggaccg gaacaattat ataagtttca 3570301 tttacataag tatgccaaag cgataaggcc aaacctgaaa gtcatgctga ccggccaggg 3570361 cagcgacgaa tttaacggcg gttacagcac gacactttca ccagccgaga acccaagttg 3570421 ggaaggattt attgaatcgg tcaatacgat ggagatgaac cggctgcatc ggctgcaggg 3570481 aaatatcttt agagtgtggg aggagcattt tggactttct cctataaacc tttcttattt 3570541 aaagagcaat gattccagcc aagcagatcc ttggcaatcg tatgtcctga caaaataccg 3570601 tgatctgcaa atgtataatt gctggcatga agatcggatc gccgcggcta atcatatcga 3570661 aaaccgtgta ccgttcttgg accatcggct tgttgaatgg gtttgcggaa tacctgatgg 3570721 actccgtaaa gacttgttat gggataagtc ggtattgcga aaatcattaa caaatgagct 3570781 gcatacaagc tatacccacc ggccaaaggt tccttttttc tatggtaagg acgtgagata 3570841 tacacataaa atgatgtttc atcttctgaa gaaaaacaat tatcagctta tagaggaggc 3570901 cttctctcac agcgatgcct ccagcataat acaggttgaa cacattcatg ccatcatgac 3570961 atatttggag gatgatcctg agtttacaaa ttttgaattt ttattaagac tggtgaacat 3571021 gggactttta tcaaaaatga ctaaagaaac cccttctgtt caattagaca taaccagcca 3571081 tttagaatcg ataacaataa aagactggca ctcacaggaa ggtgatattg ccagtcgttt 3571141 aaatatctca gccaataagt gtgaaggaca agatattttg gcgctaaacc ctggcgtcac 3571201 tctgttaagg ccggaaagcg atagtgagca ttgcatctac attgcggaag aaggatttat 3571261 tcagtttatt gtttcggagg aagacgtcgg agcttggctg catattctct gcgatattaa 3571321 tggaaaagac acacttcata cgattttaga cagacatggt gtcagccttg aagaagtggc 3571381 caaatatatt caagaagcca tcgaacacaa tatcattttg atcaaacaaa aaaatctgcc 3571441 agaaggagca tatagatgag catcttttat tcgttttccg cacttagggg attagcaatg 3571501 gggatttttt cgcctatttg gattctttat ctgatatcta aagattatga tttccttcag 3571561 attggattaa tgggagcggt acttgaaatt gctaagctta tatttgaagt tccttccggc 3571621 gtttttgctg atcgttatgg aattaaaatt tcaattgcca gttcattctt tttctccatc 3571681 cttacatggg ccttcttccc ttttatcgat tcagctgcta tttgcatact ggctatgatc 3571741 atatgggctt tatcagattc cttaatttcc ggttcttttg aaacttggat gagccgtgtc 3571801 gcaggggaag atcgattcgg caaagaaatg atgaaaaaca cacaattgct aatcactttt 3571861 ttaattattg gaagtattgc cagcgggtat ttgtattcat taaatatcta ttttcctttc 3571921 ctgctcgtta tggtgatcta cttattacta tttatttgga tgtctgtatt tattaaagtc 3571981 ccttctgttt ccgaaacaaa tcatggggat cagaaccaac atgattcgat aaagattatc 3572041 aaagaaagtt taaaaattat ctttaacaaa aaaagggttc ttttaatcgt catagccggt 3572101 ttctttacag ccacagccta tgacacaatt tcccgttact ggcagccttt tttgagtgat 3572161 ttaggctttt cagaaaagtc actgggatat atttttgccc taggagggtt taccgctctc 3572221 gttcttttga cattaaccat caggttcgaa aagaagatcg aaaaaaatcc atatctcgct 3572281 ttaacctcat tggattccat gggcatggtc atgacttttc tattgtctag agcattcagg 3572341 ccgctgggca ttccatgtac agcgtttttg cttgcaattg aagatattca tcatccgatc 3572401 gtaacaagtt acttaaataa gtttttcccc gattcataca agaacacact tttctcgtta 3572461 aactcagggg taggagcaat tggagaaatt ctttccggtg tcattttcgg catcatttcc 3572521 gcagcctttg ggctctctgc catgtttgtt gttgtagctg tatttctatt aatccctatt 3572581 atcctttata cgatagtgcc taagattaaa gacaatgata tgaaagttca gattgaaaaa 3572641 tcccagcaag tgtaaatgtt ttgtatcaca gtaagaagac cttcttatta aaagaaggtc 3572701 ttctgctatt ctattcagtt atttcccaaa agccatcagc ttcgtataac ttccaatata 3572761 aagtgttccg tcctcagcga gctgaggaga agacacgacg ttgctgtcgg tttgatagct 3572821 ccataattca ttgccgtttg cgtctgccgc ataaaccttc atatcatctg acccgaaata 3572881 aaccgttccc ttcgcgtcaa tcagcggcgc cgttctgaca gggccgtctg tgtagaatga 3572941 ccagttcata tccccgtttt tgctgatgga aaacagctcg ccgcttcctg agccgatgta 3573001 gatattgcca ttatgatcaa tcgcaggaga tgagctggag aacccgttta gcgggaatgt 3573061 ccatttcaaa ctgcctgttg atgtataagc atacagctgt ccatcttggt tgccggcata 3573121 aatgtttccg tccttatcaa tcaccggata tcctttaaac gcatttgacg tcgttctgga 3573181 ccatttcacc tgtccggttc cggagttgat cgcataaaac acgtaattat atgtgccgac 3573241 atacacggtg ccgtttttgg caagcaccgg cacagagctg acgaccccat ttgttttcaa 3573301 cttccagcgc tctgtccagg ttgattttga cgtcggtttg atcgcgtgaa cataattatc 3573361 aagtgttgag aaatacaacg tcccgtctga accgatcacc gtttcagagc ttggcccgcc 3573421 gcttaacgga accgttgtta aaatttctcc cgtttctttg tcaataaaat aaatcttttt 3573481 gtcataggat gccaaataga taacgccgtt ggtcccaagt acaggagatt gcgtatatgt 3573541 ttttccaaga ttgcccgtca cccatttgac tgagccgtct ggattaaagg ctttcatttc 3573601 cccgtctctg gaatgaagat atactgtgcc gtctccgtca atcacagccc ccgctccatt 3573661 ttgcggagtc gttctgatgt cgttttgcca tttcagcgtc ccgtctgtat ttccggcgaa 3573721 ccggctttcg cgtgaccagt taaacatggc aggcgccatc gcttgtacat catatcttcc 3573781 tggcaaaaag ccagatgctc cattattttg agaaaacacc gtttccgccg cataagcagc 3573841 tgtcggctga agcactttgg cagcgggcac atcagaaaca gcgccggccg aaacagccgc 3573901 cgccaccgca gctcccgcaa tcaaagcttt catacgaaat gacttgacca tcattgagac 3573961 ccccattata tgtaacttct aatttgtgac catcataaca tattcatcca ttttataaat 3574021 ctatttcaca aaaacatcac aaactagaaa actatgtaag agtattcacg gacgtttttt 3574081 cagcacccga tcgaaatgca gccacaaacc aaatgacgtt gacagcagcc gcagcgagac 3574141 taactcccaa aacaaagatc acctcagaaa gcagatggtc actaaagaaa ctaaacatca 3574201 agataaaacc ggccgaagac aaatgaatca aaagcccgaa gccgcaaagc accgccatga 3574261 catacctcat tgcatcgact ccgagcatat aaacgagaaa tggaatgaaa tacaagacaa 3574321 ggatcatacc gacagctgac cacatgccag ctgaattaaa ctgattggcc gccgctcccg 3574381 ttccggccag cggcgaaagt gaagccgcca caatcacggc gcaaaaaaga aacgcagaaa 3574441 tggttgtcat gatcgccacg ctattttttt ttgacatcaa actcctcctt taatagaaat 3574501 attaaccttt tttattataa gtaagttgaa tgttatattc attatatttt taaaaaattc 3574561 cagaatacat acacaaatgc tatgcttctt tctagtatat ttatatagta aaaaacaaag 3574621 gataaaagac tcatttttct gtaatatcag gattttatca ccataccata ttgcatgtac 3574681 atgtttttca aagtatacta ttccagatta attcagagga gagagaaaaa tacatggaaa 3574741 aaccagcagg attttggatt cgttttttag cttattttat tgacggcatt attgtatctg 3574801 ttcctagtta tattattcta tttattatca attctgtgtt tgtagctggg gctgtggcaa 3574861 caaaccctta catgacggaa gaagagtatt tagtgaaata catgacgctt gcatttttgc 3574921 ctactatgct gatcatgatc gtcatcagcg tgttatatta cgggctgctc acagcttcta 3574981 aaatgcaagg cacacttggc aaaaaaattc ttggcctgaa agtggtcaat gaacaaggtg 3575041 aacgggtttc tgtcggacag ggaattggcc gttactttgc ctatatctta tctggaatca 3575101 tcttttatat cgggtttatc atgatcgcct ttggagagaa aaaaggcctg catgacatca 3575161 tttgcaaaac acgtgtcgtg tataaataat agaaaaaagt ctagacgcca ataggcatct 3575221 agacttttgt tttctttgca ataggctgcc acgacagata cgtagcgctt ctccacaacc 3575281 actcaaacgg ccccatccga aagacacgaa gccaaaggtg gctgaagacc atttgaacgg 3575341 cacaaacagc aattgtaatg agcacaccgg cagcagggta cacttttcca tacaggccca 3575401 agccgtaatg ataaaaaatc caagtacaca caatagactg catcaaataa ttggtaaatg 3575461 ccatcctccc aacagcggag aatgattgca gcactgttct cactcttgtt ttatgataaa 3575521 gatagacaac cgttgtaaca tagaaaaaca tgaggaaagg cgcgccaatc agcaaacata 3575581 tttctttatc cgttacactg tacagcacct gggcgccgat gccgatgaca agcccagcca 3575641 tccataatcg ttttaatcct ttgcgatgct tttccggttc atgcaaatac cgtgattttg 3575701 ctgccgcagc tcccagcaaa aacatgctga aatatggaat ggatgcaaag aagtagttga 3575761 gcggattata cgtaagcatg ccattcgaag acatgtaaac aagacggtcg tggatccgct 3575821 gttctgcaat atccttcagg ctgccgcttc cataaacatg aatcgcttgt tttgcctgct 3575881 gtgttaccgc ttgtacccat tcctgtccgt ttgattgatc aaaacttgtc aacatgaacg 3575941 gaatggaaaa cagaagatac aaagagaccg cccatatcag cagtgttttc ggctttgctt 3576001 ttcgaaacaa gagcaggaca aatccgagca gggcatattc tgttaaaata tccccgtccc 3576061 atatcaaaaa ggcatgaatc gttccaaaca agagaagcgc cattaacctt ctcacatata 3576121 acggaacaaa ccgtttccct ttgttttctg ctctctccat catgacaacc atgccaaatc 3576181 caaataaaaa ggaaaacaat aaaatacatt ttgtttgaat gaagaatttc agtatgtctg 3576241 cggcggcaaa atcagcttca gaccacttat ccatgaaaaa attctctttt ccaagcatag 3576301 acaaatacat atccggataa ctgaaatgtg ccagattgac aaataagatg ccgaaaatcg 3576361 ccattcctct cagcacatca agcacaccga tccgctcatt tgttaaagtc ggctgtaatg 3576421 aagacatagc catcacgctc cttttttctg taccttaagg gtaggaaaaa atgaagcgcg 3576481 gtaacatcga tttaggtgtc aggccggcat gaaaacctta caatcttgtc atctttatgg 3576541 tttcatcacc tttaaatcta atgcttcgat attctgcaaa atgcgatcaa agcgcaaagc 3576601 ctgaggctca catgggaaga tgtggccttc atacgggtcg cctaacgtcc ggaaaaacgg 3576661 ttcaaataaa ccaggaacca atacgcccac catctttgta tagtgagaat caaggcgata 3576721 ggagtgaacg gtatttgcag ggacatgcag gaaatctccc ggattcagct gaatttcctg 3576781 gccatctgtc cacatcgtca tctggccttc aaggcaataa aatgtttctg tatgatattc 3576841 atggtagtga tcaacgattc ggtcaccttt agggccttca gatgatacga cgataaactg 3576901 gccatctgta tttttttgtg cagccacaat gcggtgaagc tgatctccag tcaacagacg 3576961 atctccttct ccagattcaa gaacgtatgg aaccgctcca tctggcagct ctgtaagttc 3577021 cgctaatttg gccgaacatg caggctttgc ttcatctaga aatacaatgt ccgctacagc 3577081 ggctgcttct gcaaatcgct cgtttgagac ttcttcgctt gcgtacggcg gatgttcagc 3577141 gtgatcatac ggattcccaa taacggaata caagtgcgct acgtttcctt tcatcgtgta 3577201 agacaccagt cttgttctgt ggctctgcat ccggtagctg tgcggtgttc ccgccggaat 3577261 gttggcataa tcacctgata ttaataaata gcgttcacca tcaagtgtca gttccagttt 3577321 cccgtccaaa acgagaattc cttcatgtgt gtccttgtgg acgtgaagcg gaaaggcatc 3577381 tccttttccc ccggaaagaa gcacgatctc aaacaaatca cctgtgctcc tcccattcgc 3577441 catcaccgtg gcaacctgtc tgccgaacag atagcgctcg ccttctccgc tccggagcaa 3577501 ataaggcatt ttttctttag gcaatgaatg tgtacataat gttttcatat tatcgcttcc 3577561 tccaatttag accagtctat atattatcat tcatttgtct agaccgttct atataattgt 3577621 aggagaaagg ataacaaaat gctacccttt ttttctcacc agcactggta tttgttcggc 3577681 aatgagaaga agaggcgttt tgtctttatt cgttaacgaa agcatgatgc cgccctcaat 3577741 catcgaatta atcagcgttc caagctgatt tgcttcttct tctgcaaatc cgttttccat 3577801 taattttctg gcaaaaaccg cttcccagct tttaaacacc ttcatgcaaa ccgtccgcag 3577861 cggttcactg attaacgctg tctcactcgc cagcaaaccg actggaatac ctttaatgct 3577921 ttctgtgttg tcaaattggc tggctgtttt tttgataaaa agctgaatcg cttcaacagg 3577981 atcagaggat tcatccatgc tttgctgtat cagatgttca acgatcttac ctgtatatgt 3578041 aaccgcttca attgctagtt cttctttgcc attcggaaaa aagtgataaa gcgatccttt 3578101 tggagcaccg ctttctttta caatctggtt caaacctgtc gcgtgatatc cttgcagctg 3578161 gaacagacgt gacgccgtgt gaaggatttt ttcacgtgaa tctcctctgc tagtcattaa 3578221 aacattccct cctaggtatg gtagagcgac ttatataata taaaaaagaa ccctgtgatt 3578281 gtcaaaaggg gtaagaccct tccggatggg gtaatgtaca aaaacagcgt ctaggaggga 3578341 tctctcaatg acaatcgatc attcagtcac aaatacagag cagcttgaac aacagaaccc 3578401 cgccataaaa acaaagctca aactgaaaaa gcttaaggat caggtgatcg tcattaccgg 3578461 cgcttcaagc ggtatcggac ttgtcacggc gagaatggca gctgaaaaag gcgcaaaggt 3578521 cgtggcagca gcgcgaaatg aagaggcgct gaaggagctc actgatgaac ttaaggaaaa 3578581 agggcacgac gccatatggg taaaggcgga tgtcggaaaa gaagaggacg tcaaccgcat 3578641 cgcagaaacc gcgatcagca cattcggccg ctttgataca tgggtcaaca atgcggccgt 3578701 ctcgactttc ggacacgcca tggacgtcac cgtcgaagac atgaagcgca tgttcgacac 3578761 aaatttctgg ggacctgttt acggaacaag agcggctgtc aaacactaca ccggcagagg 3578821 tgtgccgggc gcactcatta atgtaggaag cctgttcgga gacaggggaa cggtcattca 3578881 atccacatat gcatctgcca aatttgcgct tcacggctgg acggaaagca tccgaatgga 3578941 gcttgaaaag gaacaggcgc ccgtctcggt aacgctcatc cacccgggca gaattgacac 3579001 accatataac gagcatgcgc acagctacct cgacaaacag ccggctcatt accgctccat 3579061 gatctatccg ccggaagcgg tcgccgaagc gatcctgttt gccgccgaac accctaagcg 3579121 cgacatgtac atcggctcac aggccaaagc catcgccatg ctgggcgcgc tttttcctcg 3579181 tctgaccgac agactgatgg aaaaaatcat gtatcacagc cagcatgccg aaagaccgtc 3579241 caatccgaga gaagaaagcg ctctttatga tgctggctgc ggtatgcatg acagaggcac 3579301 aaataaagga tggatgaggt caagaagcta ctacacaaaa gcgacgaagc gcccaattgt 3579361 atcggcggct gttgttgccg gactagtggc ttgggctgcc gccaaacgat gcagataatc 3579421 tctgaccata agaaaaaccc atgctgttcc agcgaaccat gggtttttca gctgttaatc 3579481 gataaaagcc ttgttcatac gctgcagcag ctcgccgaac atctcttttt cctgtgttga 3579541 ccattctttc agcatctgtt cataacgttc aaggcgcttt tgctgatcgg cttttaatag 3579601 ttgtttgccg agttttgtaa tggtaaacag gctgactctc ccatcagacg ggtctgagaa 3579661 acgatagatg agctcctttg cctctaatgc agctgcttgt cttgaaagag tagaaatatc 3579721 aagcttaaac gattcagcca attccttaac acgagcaggc ccaaactcat ccaattgtct 3579781 cagtaataag tacgaagatc tctccaaatt ccctgttctt ttctccgatt gatccagata 3579841 aacagctctc ctgataaaag tcgtcagctc atattcaatt aattcaactg gattttgatt 3579901 ttgcaatcgc tctcgctccc tattccaatc tccggcattg acaacatcat atatacttgt 3579961 ataatacaaa tgtacattaa ctgaataaat acaagtcgtt atatgactaa atcaattatt 3580021 atacttgtat agtacaatca tataaaaaga aagtaaagcg attcctcaga accatcctag 3580081 aagcaagcac cagaaaggag gaagctgttc tgattggaga gcagcacttg atgtgaaagt 3580141 catacgaatt attttgcaag tgttgatatt atatgtattt tttatgatcg gggaagccat 3580201 tcagcatctg tttcatttac ccgtgtcagg aagcatcgtt ggattggtat tgcttctgat 3580261 ctgcttgggc ctccgtattg ttcccgtctc catcattgaa gacggagcag ggtttttatt 3580321 atccttcctt ccattgttgt tcatcccggc aatgacagga gtgataaact atccgtctct 3580381 catttcattc aatggcctga tgctgctgat tacagtcgtt ctcagcacca tcgtcacgat 3580441 cattgcggct ggattcgcca gccagctatt agagaaaaaa gcaaaaaaac gggaggagaa 3580501 agagaaatgc agcaagcatg tatcgcgatc attataattc ttttaacagt tgccgcttat 3580561 ttagcgatgg tcaaactcta taagcgattc ccgcttccat ttctgatccc tgttctgaca 3580621 acgacaattt tgattgtagc ggctttgatg atgtttcatg tttcctatga aggctatatg 3580681 atcgggggga aatggatcaa ttctttgctt gggccggctg ttgtggcgct ggcctatccg 3580741 ctttataagc aatggcatat cattgtcaaa cattgtgttc ccattttagg cggcgtcctg 3580801 gtcggcttat gcatgggaat gatcagcggg ctgatcttcg cagaagcatt cgggattgat 3580861 catgatctct tattatccat tctgccaaaa tcgatcacaa cccctgtcgc tattcagatc 3580921 gccgccggtc ttggcggcgt cccttccatg acagtcgtat ttgtcatgat tgcgggcttt 3580981 tcaggcgtca tcctcgggcc gcttttccta aaatggcttc gcatacgcag ctccctagga 3581041 caaggcattg cattaggcag cgcctcccat gcactgggta cctccaaagc gttggaatat 3581101 ggggaattgg ccgtatccat gagttccgtc tccatgacgc tttgtgcggt gctcggctca 3581161 ttcttcggcc cgctcgtcgt ctggctgttt catatttaac aaagaaagac tgccccgggg 3581221 gagggcagtc tttttcgttt aagaagcaaa aaaatcaatc aacggctgaa agtccttaga 3581281 taaatcaacg tcattcggtt ctgcttgaag caggcggtca atcatacgct ccagctcctc 3581341 aacatcattc ttatccgtat attcaatgaa gtttaagctt tcaagccaat cccgatatga 3581401 atgtttggct ttgccatagc tgtttccaaa gacaaggcaa ggtgttttgg tgataatcga 3581461 gaaaatcatc gcgtgaaggc ggtcggtaat caccaattta ctggagccga tgcggtccag 3581521 catctccata aaatgctttt cacgatcagc gtaatcgatg gtgtctaccg tatccagcac 3581581 cgtatcggta cgctctgtgt aagttgtttt ttctgcccat tgcttcatct gtgaaataaa 3581641 atcttcgtca gtcactttct ccttatccgc tcttaaaata aagagaacgc cgtcccgctc 3581701 gagctctcgc ggcacaatat ccaaggaaag caccatgtcc ggtgtaaaga tcacattgga 3581761 gttgaaggtc tctttcacaa catccagtgt ttgcgtctca cgcgcagcaa tcgttaagtt 3581821 tgtattttga tggtacgcat cctgtgtttt tttcttttcc ttctgtcctt cctctgtatc 3581881 ctcaaaataa acggattgtg gcagagaaat tgatttgtag tctttaaacg ccgaaaagac 3581941 ctttcttctg tcttcctcaa tatcgagata aaggtttcct aaattccctc cgcctgtaaa 3582001 gcagacaata tcgtcttcac gaatgatctc cttcaccagt tcaatgccct catccgtcgc 3582061 ataatccata atctcaatgt attcataata cggaaaatga tttttgataa atttctcttc 3582121 cgcatacgca atcgcttggt cgccaatgtt tgtgtagcta ggggaaccaa acaaaaatac 3582181 ttttcgttta tcatttaaca gagcttccgg ctccacattt ggcgcaatgc cttttactag 3582241 ttttttgcct ttgatttctt gtacagtcat atctgcgtcc tccttctggg atgaattcct 3582301 cattgtgtgt taactgtctc tacccaaaaa gaaggatggc tatgcattgg catgtgcatc 3582361 ggctatatca gaaacatcgt tttcgccaat ttgatagacg ctgcaatgtc ccgcgccgtt 3582421 ctttccatat attccgcggc atgttcaaac gcgtcttcta gtggcacggc tccggggacg 3582481 atgctgaaaa gcgcatcgat tccgtgttga tagacggcat tactgtctcg ggaaattgat 3582541 cccgcaatgc cgataacggg cacatcgtat gatttagcgg ccttggccac cccgatcggt 3582601 gtttttccat gaaccgtttg gctgtcgatt cgtccctcgc cggtaatcac aaggtctgca 3582661 tcctgaacga tactttcaaa atcaaccgct tcaaggacaa tatcaatgcc tcttttcagg 3582721 tcagcctgaa gataagttag caggctccat ccaagaccgc ccgctgcacc ggcgccctct 3582781 gtatctcgga aggttgatcc gagcgctttt tctgccatat cagcgaaatg gcttacgttc 3582841 tggtctagta catccaacat gtcggccgtc gcgccttttt gcggcccgaa aacagccgta 3582901 gcaccctttg gtcctgttaa cggattgtcc acgtcacagg caacttccag tttgacattc 3582961 cgcaatctgg aatcaagccc gctcacatct attgatgcaa gctgagataa cgcgccgccc 3583021 cctgggccaa tctcgctgcc tgagttatca agaagccttc cgcccaatgc ctgaatcatc 3583081 ccggctcccc cgtcgttcgt ggcgcttccg ccgattccga tgatcaatcg ctccgctccc 3583141 gcatcaagag ctgctccgat taattctccc gttccccttg ttgtagtgat gagcggattt 3583201 cgcttatcta caggcaccag atgcagccct gaagcagcag ccatttcaat cacagctgtt 3583261 ctcccatctc ccatcatgcc aaagaaagct ctcaccggtt cccccagcgg ccctgtgaca 3583321 acttgctcta tgatccttcc attggtcgca tcgaccagag attgaacggt tccctcgccg 3583381 ccatccgcca ccggcaattt tctgtaatca gcacccggaa agaccgattt gaaacctctt 3583441 tctatcgctt cggctgcctc cagagctgat aagctttcct taaaagaatc aggtgcaatg 3583501 atgattttca tccaaatcgc ctctttcaaa acatgattca cttaacctat tgatctccaa 3583561 tgtaccataa ttgatctgga aatacatacc atgcaatatg gtaaaaattt aaataaaaat 3583621 tagaaatgaa agtgtttgca taaaagaaat attcacgtta tcatacttgt atacaagtat 3583681 actccttgag tgaggaaggt gagtgtatgc tagactccaa agacctgttg tatcccgcaa 3583741 aatggctctc aaaagcgtca accggagttc gtgtcgcata cgagctgaga atgcggatcg 3583801 tttcaggtct gattgaaagc ggtaccattt tatcagaaaa tacaatcgcc gccgagtttt 3583861 cagtaagccg ttcgccggtt cgcgaagcgc taaaaatact cgcatccgaa aaaatcatcc 3583921 gcttagaacg aatgggagcg gtcgtaattg gtttaactga gaagaaaatc gcggaaattt 3583981 atgatgtgcg gttactatta gaaacatttg tctttgaacg gcttgtcaaa atagacattg 3584041 agcctttagt taaggatctc agcaaaattc ttgaaatgat gaaagtctca atcaaatatg 3584101 aggatgctga cgaattttca tttcaagatg tgctgttcca tgaaacgatt atccgagcga 3584161 ttgatcattc atacattcag atgatctgga acaatctaaa acccgtcatg gaaagcttta 3584221 ttcttttatc gatgcgggta cggttaaagg aaaagtatga agacttcaca aggattttag 3584281 ataaccacga gctttatatt caagccatca aaacaaagga tagggcgctg atgattcagt 3584341 ctcttcacca aaactttgat gatgtgcagg ataaggtaga agacctatgg ctctcacaac 3584401 aaatgctggc aaaaggagct gaatacaaca atgactagtt atatgttagg aatcgatatc 3584461 ggcacgacaa gcacaaaagc tgtgctgttc agtgaaaacg gagatgtggt acagaaagaa 3584521 agcatcggct acccgctcta tacaccggac atctcaacag ctgaacaaaa tccggaagag 3584581 atttttcagg cagtcatcca tacaacagcg agaattacaa aacagcatcc cgaaaaacgg 3584641 atctctttca tttcgttcag cagcgccatg cacagcgtca ttgcaatcga cgaaaatgac 3584701 aagccgctga cgccatgcat tacatgggcc gacaacagaa gtgaaggctg ggcgcataag 3584761 atcaaagagg aattgaacgg acatgaggtg tacaaacgga cgggaacacc gattcatccg 3584821 atggcaccgt taagtaaaat tgcctggatc acgaatgaaa gaaaagaaat cgcttccaag 3584881 gcaaaaaaat atatcggcat caaagaatac atttttaaac agctgttcaa tgagtatgtc 3584941 atcgattact cattggcatc agcgacaggc atgatgaacc tgaagggctt ggattgggac 3585001 gaagaggcac tgcgcatcgc aggcatcacg ccggatcact tatccaaact cgtgccgaca 3585061 accgagatct ttcagcactg cagcccggaa atagcgatcc aaatgggaat cgatccggaa 3585121 acgccttttg tcatcggcgc cagcgacggc gtgctgtcca acctcggcgt caacgccatt 3585181 aaaaagggtg aaatcgccgt caccatcggt acaagcggtg ccattcggac gattattgac 3585241 aagccgcaaa ccgatgaaaa agggagaatt ttttgctatg ccttgacgga caagcattgg 3585301 gttattgggg gacctgtgaa caatgggggc atcgtccttc gctggatcag agacgagttt 3585361 gcctcctccg aaatcgaaac agcgacacgg ctgggcattg atccatatga cgtgctgacg 3585421 aaaattgccc aacgcgtcag acccggttct gacggtctgc tgttccaccc atatctcgcc 3585481 ggagaacgcg ctccgttgtg gaatccggat gtacgcggct catttttcgg cttgaccatg 3585541 tcgcataaga aagagcatat gatacgcgcg gcattggaag gcgtcattta caacctgtac 3585601 acggtgttct tggcgttaac tgaatgcatg gatggcccgg taacccgcat ccaagcgaca 3585661 gggggttttg caaggtcgga ggtttggcgc caaatgatgt cggatatctt cgaatcagag 3585721 gttgtcgttc cggaaagcta cgaaagctca tgtctcggcg cctgcatttt aggcctgtat 3585781 gcaacaggaa aaatcgattc tttcgacgcc gtgtccgata tgatcggcag cacatacaga 3585841 catacgccga tcgaagactc agccaaggaa tacagaacat taatgccgat tttcatcaat 3585901 ctatcaagat tattagaaaa tcaatataca caaattgcag attatcagag gggcttaatc 3585961 acacacaaat agtacatgac atgaagggga gggcattacc atgccgttaa tcatcgttgc 3586021 acttgggatc ttagcattac tatttctgat tatgggctta aaattaaaca catttatttc 3586081 cctgctggtc gtatcgttcg gcgtggcact ggcactcggg atgccgttcg ataaagttgt 3586141 cagctccatc gaagcaggaa taggggggac tcttggccac atcgcgctca tcttcggact 3586201 cggtgcgatg ctgggcaaac tgatcgcgga ttcaggaggc gcacagcgca ttgcgatgac 3586261 gctcgtcaac aaattcggtg agaaaaatat tcaatgggcc gttgtcattg cctcattcat 3586321 tattgggatt gcgttatttt ttgaagtagg actggttcta ttaattccga ttgtctttgc 3586381 gatttcaaga gaattgaaga tttctatttt atttctcgga atcccgatgg tcgcggcact 3586441 atccgtcaca cacggtttcc tgccgccgca cccgggacct acggcgatcg ccggtgagta 3586501 tggcgcaaac attggagaag tgctgctgta cggctttatc gttgctgttc cgacagtgct 3586561 cattgcaggg ccgttattta caaagttcgc gaaaaaaatc gttcctgcat catttgcgaa 3586621 aaacggcaat attgcatcac tcggcacaca aaaaacattt aaccttgaag aaacacccgg 3586681 ctttggaatc agtgtcttta ctgcaatgct cccgattatc atcatgtcgg tcgcgaccat 3586741 tatcgacctg cttcaagaaa caatcgggtt tgcagataac ggagttttag cttttatcag 3586801 attgattgga aacgcatcga ctgctatgat tatttcgtta ttggtcgcag tctatacaat 3586861 gggcatcaag cgcaacattc cagtcaaaac cgtgatggat tcttgttcaa ctgccatttc 3586921 acaaatcggc atgatgcttt tgatcatcgg aggaggcggc gccttcaaac aagtgctgat 3586981 caacggcggt gtcggcgatt acgtagcaga cttattcaaa ggaacggcat tatcgccaat 3587041 cattctggca tggctcatcg cagcgatcct gcgcatttct ctaggatcgg cgactgttgc 3587101 cgcactaagc acaacaggtc tggtcattcc gttattgggc cattctgatg ttaacctggc 3587161 gttagtcgta ctcgcaacag gagccggaag tgtcatcgct tcacacgtca atgacgccgg 3587221 cttctggatg ttcaaggaat acttcggatt aagcatgaaa gaaacattcg ccacatggac 3587281 attgctggaa accattattt ccgttgctgg actgggattc attttattgt taagtttagt 3587341 tgtatgaaat taagaaggag ctgtaacaca tgttcaattc gattggtgtc ataggcttag 3587401 gcgtaatggg aagcaacatc gccttaaaca tggcaaataa aggcgaaaac gtcgctgtct 3587461 ataattacac cagagattta acggaccagc ttatccaaaa gctggatgga caatctctca 3587521 gcccgtatta cgagcttgag gactttgttc aatcgttaga aaaaccaaga aaaatctttt 3587581 tgatggtcac agcgggaaaa cccgtagatt ccgtcatcca atcattaaag cctttgcttg 3587641 aagaaggcga cgtcatcatg gacggaggaa actcccacta tgaagacaca gaaagaagat 3587701 atgacgagct gaaggaaaaa gggatcggct acctgggagt cggcatttcc ggcggtgaag 3587761 tcggtgcgtt aacagggcct tccatcatgc cgggcggaga tcgcgacgtc tatgagaaag 3587821 ccgctcctat cctgacgaaa atcgcagccc aagtcggaga tgacccttgc tgtgtctata 3587881 tcggaccaaa aggggcaggg cactttacaa aaatggtgca caacggcatt gaatatgccg 3587941 acatgcagct gattgcagaa gcttatacgt ttctaagaga aacgcttcgt ctgccgctag 3588001 atgaaattgc atctattttt gaaacatgga atcaaggtga gctgaaaagc tatttaatag 3588061 agattacagc tgagatttta cgcaaaaaag acgaaaaaac aggacagcct ctgatcgatg 3588121 tcatccttga taaaaccggc caaaaaggca ccggaaaatg gacgagcatg caggcgattg 3588181 ataacggcat cccgtccacg atcatcacag agtccttgtt cgcccgctac ttgtcatctt 3588241 taaaagaaga acggatggca gctcaagatg tattagcagg cccggaagcc gaagaaaaac 3588301 acttggataa agacacttgg attgaatacg tcagacaggc tctttacatg gggaaagtat 3588361 gcgcctatgc acaaggcttt gcccaatata agatgtcatc tgagctttac ggctggaatc 3588421 tgccgctcaa agacatcgcc ttgattttcc gaggcggctg catcatccgc gctgatttcc 3588481 taaacgtgat cagcgaagca ttcagtgagc agccaaatct ggctaacctg ctgatcgcgc 3588541 cttatttcac agataagctc catgcctatc aaacaggcct gcgaaaagtc gtttgcgagg 3588601 gtatcagcac cggaatctct ttcccatgct taactaccgc gctctcttat tacgacggct 3588661 accgcacagg gcgttccaat gcgaacctct tgcaggcaca gcgcgattac tttggcgctc 3588721 acacgtacga acggactgat atggacggcg tcttccatac gaattggtct gaataacctg 3588781 tattaaaaac acggtcagtt tcaactgaac cgtgtttttt tcttctatcc caaacaacag 3588841 aagacataag ttatgtttta aatatcataa acagtgatac aataatagct agaaacaatc 3588901 cccaagatca tcatgtgaca gcagattgct gttccgttct attctgcttt tggccattgt 3588961 cctttgccct tgaccatggt gtcataaaat gttcaaatgc caaaacggcc tggcattctg 3589021 atttacaaaa gtccctgaaa accttatcta attgagaatc agcctctcat ttattataaa 3589081 agaaatgcct aaatcctacc tgtcacacct ttattaagat gaaaaaaagt aggttatggc 3589141 ttgacaaaaa atatatatta attaataatt catatataat tagaattatt attgaaagcg 3589201 attatgcttt ctaatacatt tttaggagga atatacatta tgtctttaat cggtaaagaa 3589261 gtacttccat tcgaagcaaa agcattcaaa aacggtgaat tcatcgatgt aacaaacgaa 3589321 gatttgaaag gccaatggag cgtattctgc ttctacccag cagatttctc tttcgtatgc 3589381 ccaactgagc ttgaagatct tcaagaacaa tatgctgcac ttaaagaatt aggtgttgaa 3589441 gtatactctg tttctacaga tactcacttc gtacacaaag gctggcatga cagctctgaa 3589501 aaaatcagca aaatcactta cgcaatgatc ggtgacccat ctcaaacgat ctctcgcaac 3589561 ttcgatgttc ttgacgaaga aactggcctt gctgaccgcg gaacattcat catcgatcca 3589621 gacggcgtta tccaaactgt tgaaatcaat gcaggcggta tcggccgtga cgcaagcaac 3589681 cttgtaaaca aagtaaaagc agctcaatac gttcgtcaaa acccaggtga agtttgcccg 3589741 gctaaatggg aagaaggcgg cgaaactctt acacctagcc ttgatctagt aggtaaaatc 3589801 taaggagtgc attcaattgg tacttgatgc aaatatcaaa gcacaattaa atcaatatat 3589861 gcagctaatt gagaatgaca ttgttctcaa agttagcgca ggcgaagatg acacttctaa 3589921 ggacatgctg gctctcgttg atgagctggc ttccatgtca tcgaaaattt cagttgaaaa 3589981 agctgaatta aacagaacgc cgagcttcag tgtcaatcgt gtcggagaag acactggcgt 3590041 gactttcgcc ggtatccctc tgggccacga attcacatca ttagtgttgg cgttgctcca 3590101 agtgagcggc agaccgccta aggtagacca aaaagtcatt gatcaggtga agaagatcag 3590161 tggtgaatac cacttcgaat cttatatcag cctgacatgc cacaactgtc ctgatgttgt 3590221 acaagcttta aacatgatga gcgtgctgaa cccgaacatt acgcacacga tgattgacgg 3590281 tgcagcatac aaagcagaag ttgaaagcaa aaacatcatg gcagtgccga ccgtttacct 3590341 gaatggcgaa tccttcggaa gcggccgtat gacgcttgaa gaaattcttg cgaaaatggg 3590401 cagcggcaca gatgcatctg agtttgctga caaagagccg tttgacgttc ttgtggtcgg 3590461 aggcggacct gctggtgcaa gtgcagcgat ctacactgca cgtaaaggca tccgaactgg 3590521 tgttgtcgct gagcgcttcg gcggacaggt tctcgacacc atgagcatcg aaaacttcat 3590581 cagcgtcaaa gcgacggaag gaccgaagct agcggcaagt cttgaagagc atgtgaagga 3590641 atatgatatt gatgtcatga accttcagcg tgcgaaacgc cttgagaaga aagatctgtt 3590701 cgaacttgaa ctcgaaaacg gcgctgtcct gaaaagtaaa acagtgatcc tttcaacagg 3590761 tgcacgctgg cgcaatgtca acgtccccgg tgaacaagag ttcaaaaaca aaggtgtcgc 3590821 atactgcccg cactgtgatg ggccattgtt tgaaggcaaa gacgttgcgg taatcggcgg 3590881 cggaaactct ggtatcgaag cagcgattga tcttgcaggt attgtcaatc acgttactgt 3590941 actagaattc gcgccggaac tgaaagcaga cgaagtcctg caaaaacgtc tctacagcct 3591001 gcctaacgtt actgtcgtga aaaacgcaca aacaaaagaa atcacaggtg atcagagtgt 3591061 taacggcatc acatatgtag accgcgaaac aggcgaagaa aaacacgttg aacttcaagg 3591121 tgtattcgtc caaatcggtc tcgtgccaaa cacagaatgg ttagaaggaa cggttgaacg 3591181 caaccgcatg ggcgaaatta ttgtcgacaa acacggcgca acaagcgtac caggcttatt 3591241 tgctgccggc gactgcacag acagtgcgta caaccaaatt attatttcta tgggatcagg 3591301 tgcaactgcc gccctcggcg cgtttgatta cctaatccgt aactaatata agaaatccgc 3591361 tatattgcca gattggcagg atagcggatt tttctttttc tacagaaaaa aaccgaacca 3591421 ggcactacgg taaaagtgct cgattcgagc gcttcttata gttcctcacc attcgtttga 3591481 atgacatttt tataccactc aaaggagtct ttcttatatc gtttcatgga tccgtttcct 3591541 tcattgtcac gatcaacata gatcatgccg tagcgttttt tcatttcgcc agttgtgaag 3591601 gagacaatat caataatgcc ccacggcgtg tagccaatta aatcaacacc atcgtacgtg 3591661 accgcttttt tcaatgcttc aatatgcgat tttaaatatt gaatgcgttc cggatcatga 3591721 accttgccgt cctcctccag cgtatccact gcgccaaagc cattttcaac gatgaataac 3591781 gggatttggt atcggtcata aaaacgattt aacgtatatc tcaacccggt tggatcaatc 3591841 gcccatcccc agtcactcga agtgatgtac ggattttcga caccattcgg caagccgcca 3591901 tttacaatat cgccagtgtt atcatttttc acatcgcttt tcacagttgt tgacatgtaa 3591961 tagctgaagc ctaagtaatc gacggttccg tttcttaaaa tctcatcatc gccgtcttcg 3592021 aatgtgatgt tgtagccttc gcgttcaaat tccttcaacg cgtagcttgg ataataaccg 3592081 cgaacctgca catcagggaa gaaatagcgc tgcctcattt cttcttcagc cagcatcaca 3592141 tcttcaggat tggaggagaa aggataaatc ggcacgtgtg ataccatggc cccaatctgg 3592201 aactctggat tgatgtcttt tccttttgcc actgctaagg cgctcgccac taattcatgg 3592261 tgcgccgttt gatacatgac ttccttggcg ttttcgtttt cgccaaccac aacacctgaa 3592321 ttcgtccata ggaacagcgg attgttcaca tccatttggt tgttaatctc gttaaatgtc 3592381 atccagtact tcactttatc tttgtaacgg gtaaagcaag cctctgcgaa gttgacgaag 3592441 aagtccacga ctttccggtt tctgaagccg ccatattctc ttgccaggtg cagcggcatt 3592501 tcaaagtgag acagggtaat gaccggctcg atcccatgct tcagcaattc atcaaacaca 3592561 tcatcataaa actgcaaacc agcttcgttc ggttcagcct catcgccttt cggaaaaatc 3592621 cggctccagc cgatggacgt ccgcagacat tttaatccca tttccgcaaa caaagcgata 3592681 tcttccttgt atctgtgata gaaatcaatg gcttcatggt ttggataaaa ttcgttttct 3592741 tcaatcgtgt cagtgatttt tctcggcacg ccgtgcgcac ccgctgtcat cacatcgacg 3592801 acactcggcc ctttaccgcc ttgattccat ccgccttcaa attggtgggc agctaaagca 3592861 ccgccccata aaaaatcctt tggcatgttt cccatgttta attcctcctc agcttacgac 3592921 tgtaaatatt ttttgatgta atgcactttc ctcaatgtct tcaatgaaag ctttatcaaa 3592981 ctcaacaagc acttcgcctt ttttgacggt atcgccttct tttaccttca aggaaaaagg 3593041 cgtgccgtca aatgtcaccg tatccagccc gatgtgcgca agcaattcga cgccggacgc 3593101 tgaacgcagg ccaatcgcat gctttgtagg cgtaaccatg acaaccgtaa tgacgccggg 3593161 atggtagcat cgatttcacg atatccttcg ctttaggggt agaccgcttc agcaccaatc 3593221 gaagtctggt agcgcagcga gaagccccaa tcacattctc ttccccgcct acggcctcta 3593281 aaatgtcttt tgctagtctc gtataatctc tcactttccc cgacatttca cccacccctt 3593341 cgttttggtt acgctttcat tataattgta acggtataat ttatcaattc cgaaacaaaa 3593401 tatttacgca ctaactatca ttgtaagcgg tttatgctat aattttgaca agtgaaacta 3593461 aacgaataaa tgaggaatgc gtatgttaaa ataccagcaa atcgcaacgg aaattgaaac 3593521 atatatagaa gaacaccagc ttcagcaggg agacaaactg ccagtcctag aaaccctcat 3593581 ggcccagttt gaagtcagca aaagcaccat cacaaagtcc ctcgagctat tagagcaaaa 3593641 aggcgcgatc tttcaggtca gaggaagcgg cattttcgtc agaaaacata aacgaaaagg 3593701 ctatatcagc cttctgtcga atcagggatt taaaaaagat ctcgaggatt tcaacgtcac 3593761 ctcaaaagtc atcgaactgg acgtgagaaa gccaacaccg gaagcggcgg aaaacctgaa 3593821 catcggaatg gacgaggaca tctactatgt caaaagggtc cgctacatca acggccagac 3593881 cctttgctac gaagaatcct attacaccaa atccatcgtg acgtatttaa acaacgaaat 3593941 cgtctcccac tccatcttcc attacatccg ggaaggactg gggttgaaga ttggtttttc 3594001 tgatttgttt ctgcacgtgg gccagcttaa tgaggaagaa gcggaatatt tgggattaga 3594061 ggctggactg ccgaagctgt atatagaaag tatttttcac ctgacaaatg ggcagccgtt 3594121 tgattactcg aagatttcgt ataattatga gcagtcgcag tttgtggtac aggctaatag 3594181 ttttttatta tagggctctt cactacggta ggtggtcgac atgtacaaaa ttatcattcc 3594241 tgccatacta gccatctttg cgctctggat actcttacag atttcactag agatgagcat 3594301 cgttaagaat ccaatgaact actttatcgt attcattatc tttttcctct ttgtaaagat 3594361 ggtgaaagaa aaacaataat agtttgggcg atgcaaacag aaaaacatcc ttcccttaac 3594421 aaactcagcc agtcacatgc attaatcttg atgttaatga tatataggtg cacataaaaa 3594481 gctacttcat tgtgaagtag ctccctttat taaaggccca ttttgatcca tctagtttta 3594541 gaaaagcgaa ggacaatcgc atttatgata ataattgaaa ctaaatacaa aataataaat 3594601 aaaacatcat tactcccaag tgtcatgtta tcagattgca gcactctttc tattcggggg 3594661 tacatagtgt tacctgcctc aaaaggagca atgaaaccaa acgttttatt gcttatagct 3594721 actaagataa cagaagtcat ccaataaacg atactgacac ctatactaat taatatatta 3594781 ggacataaca cgcttatagt tccgataatt agaatatact gcagtataac tgcagaaaat 3594841 aaaaaaagta ataatgcaaa atgcgaaaaa tcatggtaca tcaacgatat gattagcagg 3594901 cctagcgtta taaatgcaaa acattctaaa aataaaacag ctatcttttt ataaaagaaa 3594961 gtatagatgt tctctccaat taacttgtaa aagagaatat ttttgtttga atactctcta 3595021 ttaataaaga aagctataac aaatgaaaat aacatcaaac caaactgggt cgcaacagta 3595081 taggagctaa agaaaaacat ttcaggtgta acattactga ctttatcgat tccaacaagt 3595141 aaaaaataac ccagcaaaaa taaaaataca aacattgctc ctaaaataat gataactttg 3595201 ttgctaatac tctttttaaa ctctaatttc atctcaagcc cccactgttt tattactcat 3595261 ttatatacac ttcaattaat ttatccactg aatgatattg ttgaatttct tggtgattaa 3595321 atatataata atccccttct atcgccttta aatcagacaa atcatgtgta atgttgatga 3595381 taatcttctc ggggttctcc tgaatatact tgtttaagaa gccatgaatc tctataaccg 3595441 tttttttgtc taatgaattc gttatttcat ctaaaacaat aatattttta tcctctaata 3595501 agaaactgag caattttaat ttttgctttt gtccatcact caaatttttg atcagaactt 3595561 ttccatcaat attatccaga ttaagtaaat atgcgatttt atctatcatt tttgcatcaa 3595621 attttttact caaaaagtgt aataaaaagt ccttagaaac atcattaggt atattcgacg 3595681 agctggatat taaagaaaca ttttgacgaa tatctctgcc gattcttttg ctattattca 3595741 acaaaaagtc tttagcaagc tgtgatttac cgactccatt ttttccgaca acgtgattaa 3595801 ttttcccgct cgaaaaatgc aagtcggtgt cctgaagtaa cgttttgcct ttcactttta 3595861 aagtgtaatt cgctatattc atatacatac tcctaggaaa tatttgcata ataataaaat 3595921 gttctgcctt gtgatttgtt actaatgtct aagcttttga ggtacctctt tcgtttccga 3595981 tccggaagcg aaagaaatgt ttttagatgg ctaatttgga gatcttttac tctagtttac 3596041 aatatataat atccaatgta caactgaatt cactgcaagg ccaatcccta taatttgaat 3596101 cgtaagaact aaccaatgat ttgtcttaaa acggctatat tcatctaagc tcagaaaagc 3596161 taaaagaatt ttgtaaccat cagaattcaa tattgggatt aagttccaca ataaagtaga 3596221 cgagaaaagc ataaatgcca tagttaatgc ttcactggaa aatgtaaatt gatttattaa 3596281 ttctaatgta tttattaaaa gataattgat aaacaagcca aataaatgaa cgattatctt 3596341 ttcatttctt gatagcatgt aggtttcatt caattggaca taaaaagcag gaaatacata 3596401 aaaattcagt ttgaatccca ctttatcaaa gtttttcccg aaaaatttta aggaataaat 3596461 atgtcccagt tcatgaagca ctatattcat tataaaataa ataactataa ttatccacat 3596521 tttccagccg taaaatactg aggacaatcc attttgcaat tttattaaat gaatataatt 3596581 taatatgaac atgagagccg taaaggataa gaacagataa aaaaactttg gtgatacttt 3596641 ctctttatac attttaaaac gtaataattg tttatctgac agagaattta aactattttt 3596701 atagtattct ccgctttttt tgtcttttat aaatacgttg ttttgcacaa gcacttcata 3596761 tttttcatct tcatacttta aaattttcat tatagtattt ttccatataa ggatagaagt 3596821 agtttatttt ttctgcagag ttgaataagg aaccacaaac tccacaaata gaggaaaatt 3596881 cataaggaat gtcaaattcc tctattttgt tattttcttt taaaatattc aaaaaccatt 3596941 tgaatccttc ttttctaaga ataaataata gcaaattgga atttaacttt tccacggttc 3597001 tttcgaaact ttggttatat tcttccctta gggttatttt cgtttcaaaa atagcagggg 3597061 aacaacatgg ataaatttct ccatcatgat gatatacaat gtcatatccg ggacaatgta 3597121 aggaatcttc atcttcaaga ctgtaaaatt tatgtatgtt ttcttgctta attctagttt 3597181 tagcagcgcc aactgatatc attggaaatt ttgttatctt tacacctaag attgaatccc 3597241 ccaattcctc taaaatgtgg ttggacattt tgtctttggt aactgccata ttaagagaaa 3597301 tatcgatatc agggtatttc ctgctatgtt ctaatatgtt tttaatactg gaagacttga 3597361 caaatggagc atggtactca tcataactta tagtcagtgc tatcacattt aaagaattca 3597421 tatcatgaaa gtactcctgg acctttttct tgctcaaacc ccaaaatcca ttagagatca 3597481 acgttatttg tttttcatat ggtttaatga tttccattag ttcttttaaa aatttataat 3597541 ctaaaaaaac ttccccacct gtaaaagaaa tcacttgaat ggttttgttt tttgcaaatt 3597601 cagttactaa ctctcttatg tattcttttt ccatcctggt tgttgaagtt ggtgaactag 3597661 aaaaacaaca atggtcacag gatgcattac accttgaatc taaattgatt gatactgttt 3597721 tattatacat gaaatatccc ccaacaaatg gtaaaggaga gttagactct cctttgtacc 3597781 cctctaatta atgaccactt ccaagaatcc agcgattttc ttttgatttt acaaaatacc 3597841 aaagatcatt cacttttgct aacttttgtg attcatctaa tagaccctta aattctaagt 3597901 ttttcacagt ctcattgtta gtgatttcct ttttcatatt atccctcctc cttttctaat 3597961 ataaaccaat tattctatat cattcaatac atgtcaatat attgtaccta aaaaatctga 3598021 aaaatgtcac tattcttggt atataaagcc tatagtcctc tagcccctct aagctatacc 3598081 gaatgaaagg ccatagtttg atttaaagct tcgtaatgaa aagtaaaaca tcaatattga 3598141 ctacactagt taagggatat acagatttta agtggaagaa atgaggcaaa caatcttacc 3598201 ctaaaccaac ctgtactgaa aagctgtttt aagctcttgc ttaccccatt tggcacctct 3598261 ttctctcgtt ttaattgtct ctaaaagcag ttatgcggta ctatcatata aaggtccaat 3598321 gtttaaaaat aatgtcatac ttttaaattc accttatcat gcacatgctc ataaagaggg 3598381 gtttattcta aaaaggggat ggacggtttt ggaaagcaag tacctagatc tactcgcaca 3598441 aaaatacgat tgtgaagaaa aagtggtaac agaaatcatc aatttgaaag cgatattgaa 3598501 cctgccaaaa ggcaccgagc attttgtcag tgatctgcac ggagagtatc aggcattcca 3598561 gcacgtgttg cgcaatggtt caggacgagt caaagagaag atacgcgaca tcttcagcgg 3598621 tgtcatttac gatagagaaa ttgatgaatt agcagcattg gtctattatc cggaagacaa 3598681 actgaaatta atcaaacatg actttgatgc gaaagaagcg ttaaacgagt ggtataaaga 3598741 aacgattcat cgaatgatta agctcgtttc atattgctcc tctaagtata cccgctccaa 3598801 attacgcaaa gcactgcctg cccaatttgc ttatattacg gaggagctgt tatacaaaac 3598861 agaacaagct ggcaacaagg agcaatatta ctccgaaatc attgatcaga tcattgaact 3598921 tggccaagcc gataagctga tcaccggcct tgcttacagc gttcagcgat tggtggtcga 3598981 ccatctgcat gtggtcggcg atatttatga ccgcggcccg cagccggata gaattatgga 3599041 agaactgatc aactatcatt ctgtcgatat tcagtgggga aatcacgatg tcctttggat 3599101 cggcgcctat tccggttcca aagtgtgcct ggccaatatt atccgcatct gtgcccgcta 3599161 cgacaacctg gatattattg aggacgtgta cggcatcaac ctgagaccgc tgctgaacct 3599221 ggccgaaaaa tattatgatg ataatccagc gttccgtcca aaagcagacg aaaacaggcc 3599281 agaggatgag attaagcaaa tcacaaaaat ccatcaagcg attgccatga tccaattcaa 3599341 gcttgagagc ccgattatca agagacggcc gaactttaat atggaagagc ggctgttatt 3599401 agagaaaata gactatgaca aaaatgaaat cacgctgaac ggaaaaacat atcaactgga 3599461 aaacacctgc tttgcgacga ttaatccgga gcagccagat cagctattag aagaagaagc 3599521 agaagtcata gacaagctgc tattctctgt ccagcattcc gaaaagctgg gccgccatat 3599581 gaattttatg atgaaaaaag gcagccttta tttaaaatat aacggcaacc tgttgattca 3599641 cggctgtatt ccagttgatg aaaacggcaa tatggaaacg atgatgattg aggataaacc 3599701 gtatgcgggc cgtgagctgc tcgatgtatt tgaacgattc ttgcgggaag cctttgccca 3599761 cccggaagaa accgatgacc tggcgacaga tatggcttgg tatttatgga caggcgaata 3599821 ctcctccctc ttcggaaaac gcgccatgac gacatttgag cgctatttca tcaaagagaa 3599881 ggaaacgcat aaagagaaga aaaacccgta ttattattta cgagaagacg aggcaacctg 3599941 ccgaaacatc ctggcagaat tcggcctcaa tccagatcac ggccatatca tcaacggcca 3600001 tacacctgta aaagaaatcg aaggagaaga cccaatcaaa gcaaacggaa aaatgatcgt 3600061 catcgacggc ggcttctcca aagcctacca atccacaaca ggcatcgccg gctacacgct 3600121 gctatacaac tcctacggca tgcagctcgt cgcccataaa cacttcaatt ccaaggcaga 3600181 agtcctaagc accggaaccg acgtcttaac ggtcaaacga ttagtggaca aagagcttga 3600241 gcggaagaaa gtgaaggaaa cgaatgtggg tgaggaattg ttgcaggaag ttgcgatttt 3600301 agagagtttg cgggagtatc ggtatatgaa gtgaggggtg tggggttcag ggatggtgat 3600361 atgctgctcc cctaaaagta gatagatgaa ttttagaaaa tctgtttgcc ttggggagtt 3600421 ttttcatggc tggacaatta tactacaagg aagaaatact aatacttata gaatgtaatt 3600481 gggtaatgat tcggagaaag aggttgcgaa ataatatggt attacactga aacaattatc 3600541 aatggagaac atgcacgata tagccgttct atattctccc tctattatgg cactcattag 3600601 tagacataac cgtaaaaaaa tgcactcaaa aaaagtccat tctatataac tctcgctagg 3600661 gtggaccttt ttcaacattc aaagtactag attttttcta gtgaaagaat aagaaaagac 3600721 ataagttcta ttttatcact ctgttatagg ttaagttatt acggtgtttc attatatact 3600781 gaatttaaac acccttgaca ttatgggaat ttttaaaaca ggttaaaagg aagttctata 3600841 agaactccct agtttaatat tatttggtca aaatctaaaa ccaaaaaatc tatttttatc 3600901 ttcattgttt ctatctaatt ttgcaacaat catacctttc gactctaatt cttgaaggtc 3600961 atctaataat aattcatttt tatttattgt tacaaaatat tgtccgatcc tattctctaa 3601021 cagacttgaa ttgatatgtt ttaataatgt accttttaca tgaggatcag gattagaata 3601081 agatccgtca tgaattaaaa tattcaaact acacttattt atacacctgt ataaaaacca 3601141 agtaagatca aatatattta tcttcatatg gagtctacca tgtgaacgtt catccggtat 3601201 agaacaagaa attttgatcc ttcctgtagt tgattgtttt gcgttactta ttctattatc 3601261 atattcaaaa tctaaaaatc catgttggtt gtatgtaaca tccattagat tattaaaaag 3601321 cttctttaac tcactaacta tagcgctata agattgaaac tcatcataat acattgaatt 3601381 aactcttaat atttcatgtt gaagttcatt aatcttatca aaaatatggt tttttttatc 3601441 gtagtcacta attctcaatc ttacttccgc taactctatt tctttccttc tttgttcttc 3601501 catcacaatg gaaatatcct caatgaaatt gttactcttt aaaattctgg cacttgattc 3601561 cagttgttct gttaatcctt gctttttgat attaagtttt tttaaatcgg cttgtatttt 3601621 aacaatttta tctttaaaat aactccctct actttctacc atgaaattat agaactcttg 3601681 gactttatta taattctgtt ttacttcctc tggaaaaaaa cctacaatat cttcatagaa 3601741 tttttctata ttttctaatt ctttaatctt agttactttt ttatttaaat catctatatt 3601801 tctttgatat tgtttacaaa tatgttcatt ttcaaatatt tcattttgta ttttattaag 3601861 ttcactttta atttctgagt acctatttgt atcattatta tatttattgg cagtcttagt 3601921 ttgatagata actctattgt aatcctctat ctcatttatt aattcatctt ccttaacttt 3601981 taaatcgcca atgttaatat tcattgattc aatcaatttt atttcactat ttaatttttc 3602041 aatcttatcc cgaaaaacct ttatgttttt ttctgtatga gttggtaaag taaaaagata 3602101 gttaagtaat ttatattgtt ttaaccctcc cctattcggt aaaactatat cattaaaccc 3602161 tgtcttttcg tctcttataa tatactccct taacgccgca aaagttatat cctctttctc 3602221 accctttaaa atttcctttt caataaattt tttatataca cttatactaa cttttttcca 3602281 ttcctccaaa ttaaaagtta aagaagtatc atgtaatgta taaccatgtt taggagaatt 3602341 aaaagatcta gcaaggaata cttgatttcc atcaatttcc acattcaaaa caataaaaac 3602401 gtttttattg agaagaattt catttgtcgt ataaaaattt gatatagtct tccctagtaa 3602461 aaaggagatg cattcaatca tcgttgactt acctacacca ttagtctctt catgatcttc 3602521 tctcttttca ccaagtatta tatttactcc tacagcatta aatttatact ctttcaaaat 3602581 ttcttgggaa ttgcaaacaa aaagattttt tataatcata acaatcacta actctccgtt 3602641 ctgctaatca tattttgatt aaaagaaact ttacctaatg aatataaaaa agttaacgat 3602701 aaatacagta tccgttcaat attcaaattt attataatac cttgactctt agcataatca 3602761 agaaaaagtt gatcaatatg tttttccttc tctaacagtt cataaagtat ctttgatgag 3602821 tataaaatat tttcttccac agcattatat ttagttaata aaaaatgatt catttctggc 3602881 ctctccgcct tttccttttt taaaggagaa ttattcacta gaggaataag atcatttcca 3602941 atttgaatgt ttttaaactc attttctaat aaaacataag agtatttgag aatattttca 3603001 gctgtttcaa ttttaagatc aatcattctt aacacttctt ttgttatcat taaaaatctc 3603061 acattcataa atgcaccaac atgttaaaat cttaatgtat tttttcgtta aagcctttga 3603121 atatggtaaa actgaatgac attctagata aatctcatta acaattttta caaatatctc 3603181 atctccatta ttatattgat tatgaaactc tagatatttg tctactatcg tctcagcaat 3603241 caattccttt ttatcagcac ttacatacga agtggaatcc attatatggt ttatcacacc 3603301 aaaatactca gaataactat cgaatttccg tttaaaagtt tccccacttt tcatatcata 3603361 aaatttttta tctaaaccaa tttgattatc aaaattacta gtaaatgttt tataactttc 3603421 tctatactca tgaaaatcta taataaagct cttaaactca tcttcatcaa ttttatcatc 3603481 gttatcttct atttcttttt caataaggct ctctaatcta ttaatcttat aatttaactt 3603541 cccttcctgt agtctccttc ctccttggtt gttttttgac cagtatttat attcggtatt 3603601 ccaaatgtag tatgttactt ctgtctcgcc attatctaaa ttcacatcca ccgaaataaa 3603661 ttctggagta gcatactcat cctttataat ggctccactt actaattcta agaatggatt 3603721 ttcatttgta tttgcagtaa tattaaatga agaatcatgt acatgtcctg ccaaatatag 3603781 atcaataaag taatcatcaa aatgtgcctt tattgattct ctttcggaag attcaataca 3603841 acctaacgta tggtgcccaa tagctatatt taataccttg cccttatttt tctctttgtt 3603901 catcttcctt attgctttat ataatttcat ctgtgcagtt aataacgttc cttcttcacc 3603961 ttttttatct gataacagac atgtatttat tgataaaaca ttatacttct ccgattgata 3604021 caaaaaatgc aaatcttctt ccggatattt aacacccata aaatcttcat aaaaatcgaa 3604081 aaatttcctt tgaccttcca ctaatatatt tgtagctttt tgatctagtt tatccaacat 3604141 ttctgagggg ttaggagatt tcataatact atcaatcaaa agtgtcctcg tcatgtctct 3604201 agatatatcg tgatttcctg gcactaagtg tacgttattc ttacttaatc ccatactttt 3604261 aataattcca ttaagatatt ctttaacatc ttcgttatac acatcacctt tgtgtgctat 3604321 atctccagtt aataataaaa aatcaaaatc tgactctctt cttaaaactt ctataaaatc 3604381 taataattta tctctcatta caatagtgtc ataattttga aactgaaaat gcaaatcaga 3604441 aatttgtaaa aaacgtacct tcaatacaaa catcctctca taagtatatt tatcccctat 3604501 atatttctag aaaacttttt attctatatc atctttactc tttaatatat taagactctt 3604561 tccacaccat caaataaatt ataacctaaa cataactctt tactcatttt agtattgtat 3604621 ttaagtcaaa cattgcattg gttgctgaaa tattatattc attgaattat tccattaaat 3604681 agcttttagt tgaactttag tctttctgta atggtggaga tgctcttact tatgataagg 3604741 ctccccacga ttaatccgaa aagcccgata aatctgctcc actaaaataa gccgcatcaa 3604801 ctgatgagga aatgtcatct tcgagaacga tagcttctcg tccgctcgct tcatcaccgt 3604861 gtcactcaat ccgagtgatc cgccgatgac gaaggtgact ttgctttttc cataagtagc 3604921 cagcttatct attgtatcgg ctagttcttc ggatgttttc atttttcctt cgatggcgag 3604981 ggcgatgacg tgggcgtcgg ggctgatttt ggataggatg cggtcgcctt ctttgtcttt 3605041 tatgattttc atgtcctggt cgcttaggtt ttccggcgct ttttcgtccg ggagttcgat 3605101 gatgtcgatt tttgcgtagg ccgaaagtcg tttggtgtat tcttcaatgc cttgcttgag 3605161 gtatttttct tttagttttc cgattgtcac aatattgata ttcacaggtc atccccactt 3605221 taaaaacaag ttattcatat atgttgtcca caattgtgga tatcttttct gtattttgtg 3605281 taagatcatt cgttccccac tatatatact gcggggtctc cacataattc acaggctgtg 3605341 gataaactgt tagtatgttc gatttttctg atttcgggcg gcagctcgtg gtcgtctatg 3605401 tacatatcca gcaccgtttc gatgtgttct tcacaagaat aatacgcttg tttcatgttc 3605461 aaatcctccg atgttttctt ccatttttac aaatgttctc ttctcaatat aacctattta 3605521 ttcacatgtt agtagtgctt cgggctgagt tttatccaca attcgacaaa caagctgttg 3605581 atgactctat ttcgctcgtg tgttagtttg gatgtaaccg atgtgtgggg aggtctgcat 3605641 ttgcgcttta gatgggtttg gctttttgtg attatgttgc tgcttgctga gtgtcagcca 3605701 tcttattggg tgttggagaa ggatcgaatc ggtgaaggca gtccagactt agaaatatac 3605761 gctaattatc tccaaatgca tgatgacgtg aaaggatatc aagtcttcac catatcagaa 3605821 ggcaaaaaaa tggtcgtcgt gtctctcgga agcagcgaga aagataagaa gcttgaagtg 3605881 tcggacgtca aattctcatc taaagaaacg attgtaactg tggagcgaaa acctgctcct 3605941 acggcaaatg agaaaaaccc ttttattttg attggactgg acaaaattga aggggattta 3606001 attgttcaag acgaaacagg agatcgcttt gaagaaacgg attaccagca ataaagccgg 3606061 cgttctgaga acgtccggct ttttctttta cttcaatgtc ccatgcgggt cgatgacgaa 3606121 ttttttggct gcgcctttgt cgaagtcgct gtagcctttt ggcgcgtcgt ccagagaaat 3606181 aacggtggca ttgacggctt ttgcgatctg cgctctgccg ctcaggatcg ctttcatcaa 3606241 attgcggttg tatgtcatgg cgggcgtttg tccggtgacg aaggtgtggg ctttggccca 3606301 gccgagtccg aagcggattt ttaatgagcc tgttttggcg tccgcatcct ttgcaccggg 3606361 atcttcggtc acgtataagc ctggaatgcc aaggctgcct ccgacctggg tgacgtccat 3606421 gattgagttc agcacggcgg ctggcgcttc tccttgattg ccgtgcccag atgcttcaaa 3606481 gccgacacag tccactgcag catcaacggt tggttcacct agtatttgtt caatttgctc 3606541 gccgaggcgg tcgtgttttt gcacgttgac cgtttcacag ccgaagcttc tggcctgtgc 3606601 cagcctgtct tcgttcagat cgccgacaat cacggtagag gcgcctagga gctgagcgga 3606661 gtgtgcagct gccaagccga caggacccgc tccagcgata taaacggttg aacctgtttg 3606721 cacgcccgct gtataagctc catggaagcc ggtcggaaaa atgtcggaca gcatggtcaa 3606781 atcgagaatc ttttctagcg cctgttcttt atcagggaat accaaaagct gaaaatcagc 3606841 gtatggcacc atgacatatt cagactggcc gccgacccag ccgcccatat cgacgtagcc 3606901 gtaagccgat cccggccggt ccggattgac attcaggcac acatgcgttt tctgcgtttt 3606961 gcacatcaca cagcgtccgc aggcaatatt gaaaggaacg gatacgatat ctcctttttt 3607021 gataaattca acatcacgcc ccgtttcaat gacttctccc gtaatttcat gcccgagcac 3607081 caagccttct ggcgccgttg tgcggcctct gaccatatgc tggtcgcttc cgcaaatgtt 3607141 ggttgtaatg actttgagaa taaccccatg ctcacatttt cgattcacat tcgccttcgg 3607201 gacgccgggc ccgtccctca agattaactc cggataaccg atatcctcca ccgctacagt 3607261 ccctttgcct ttgtacacaa ccgctttgtt tcctgtcaac gccattcctc ccattcatgt 3607321 gtttggactc tccgtccttg aacatgactt cggttcggca tgactctttc cctttttcac 3607381 gactgttttt tctgtattct tacaacaaca aatatgccaa gaaagcatcc aataatggtt 3607441 ccgccgatgt ctaagaagtc gactttacat ccatttaaca agaacacagt aatggccgaa 3607501 accaggcaga tcataactgc cagaagaata acccgatttg tctgcatgta attcctcctt 3607561 tggattcgtt tctaaaccat acccaaaatc ctctgcaaac ttcggttcaa caaaaaaaga 3607621 gacttcacac cagtctcttc ataaacagag atcactcaaa aaatttcctg agaaataatg 3607681 tggcaacact cgttactaac gcaattgccg tatacataac aacccaaaat atgaatgagc 3607741 tattccccga agctaacgta actaacaata tcaagctcgt gataagaacg atgagcggtg 3607801 ccacccaaaa tcttttaaat aaaaaatgac ccgctatacc aaatacacct gcgacgatcg 3607861 gaaaaccaaa aacgataaat aaaacggcga tggctcccat actaccctcc ttgccttaaa 3607921 acctcttcat cacctcaaca tcatacagct tcaaatgact cttcggcgtc acgacatcct 3607981 ttaccttccc aatctctttt tctttcattt tctttccggt tttcaggctg tactgttcaa 3608041 tgtaggcagg cttgtgatac gtgtatgtga agaaatagag gctgctgcct ttttgggtga 3608101 tttctttgaa ttcggctttc attttgtccg gggaaagggt gaagacgatg cttgtttttc 3608161 ctgtcttggc atcgattttg tgtacctttc cgaagccgtc aatgaaatac aggttcccgt 3608221 cataagggaa aaagctgttt ttaaagctga agggcatgga gctgtatatc gtttgttcgt 3608281 cgtttttgta ttcggcgata tcgtgcagct ctacttcgcc gctttttttg ttgatcttga 3608341 ccatttgata gagatcgtgg gctttttggc cgcgaaccat aacatacaca gcttggtcgt 3608401 ccacggcaag ttgggattcg actgaggctc cttcccggta ctgccattcc gttatgctga 3608461 gataggtaag cttcttctga tctgcttgaa tctgaaggag ctgatagcct tttccgtcat 3608521 ctgtcgggac gagtgcgtaa atggcgccat catggaaacc ggaggctcgg atgtagtagg 3608581 ggatgacgtc ttttttccac tctccgtcca tttggcggta cagctctgag cggtatccgt 3608641 ctcccttttt gtcgtagccg gagttgtata aggtgtaaaa gccgtccgtg ttttgcagaa 3608701 agcccgcgct gtcgcctgtg tgctgatagg ttcttttatg ggagcgcagg ccgtttttga 3608761 tcgtataaat cgtgtttttg tcctccagca tcacgctgtc accgtgaacc tttgctgagc 3608821 ccagctcaag gcccttcatc tgaaaggaag acagcgtccc gtcatggctg ataaacaggg 3608881 cgtagctttt cccgccgcca aatgcatctt gatccgcaga ggatgagaaa tacagcagga 3608941 cttctttgtc atccaggaaa tcgggatttc tgagatcctg ctgactcacg gttttatggc 3609001 ttttgagagg agaaatgaag acaaatagtg cgattcctgc gagaatcagc atggcgatgg 3609061 taatcatcca ctttttcata gccttctcct tagtaaatgg tcataatggt tgtcgtataa 3609121 gaagaactag tgatgtcgcg cggatacacg cctaagcctc cgttgctgtc tatatcaatc 3609181 cctgctttca gcaaaaaggc agaccatagg agctttgaac agtttttggc gccgtcatgg 3609241 ccggtatttc tgttattgac gaagttaaat gagtatgggt cgccgacttt tgataccgcc 3609301 cagtcggcag cagctgtttt ttgagatgag gatacgctga cggtttgcac aatggagttg 3609361 tcttccacgt ctctggcatt atacgcgatc tgcctgacgc cgtcgctcgg gacagattca 3609421 acaattttgt cagcggcgga gtacatgccg acatggccgt gattgtagta ggctgtgtag 3609481 gagttcgtgt aatagatatt gcctttcgcg cttgtcggga gttttttcgt gccggacgag 3609541 ccgcccatga tagacatgcc gctttccttg gcgagccggt ccccctctgc tttatcagcc 3609601 gtgatctcct tatagaactg ttttaggata acgtcctgct ttacgtgctg ctgtttggca 3609661 atctggctgg cagatttcat gatttcttcc ggtgtcgtgc ctggctgcag tgcggcgatt 3609721 tcttcagcat aatttgtggt ctttacggct ttggcgggag taacaaacag gccgccgcac 3609781 attgtgagcg ctaccaaaaa catcgacact cgtttcttca acttcattac atctcctctt 3609841 ttcttgtgag tgtaggaaag gtaatttcct cacccacatt atattaggaa aataaggaaa 3609901 gtaactaggt tatttacaga atttttagaa atcgtttaca gaaaaaggcc tttatcaggc 3609961 ccttttcgtt aaagcttctt gctcatcact acgtctgttt cttgaaatcc ggtttgctca 3610021 tatagctttc gagccgtctg attatgggca aagacatgaa gggacagctt gcggattccc 3610081 atactgcgtg ccgcttgatc taatgccgcc aatgcttgct ttgcgtagcc ctttccccga 3610141 tacggttcat ataacccgaa atcataaata aacgcttcct gctgcggatg ctccggttca 3610201 gcatgtatcc agagccagcc aacgatatcc ttttcattca gcttgaggct ccacaaatgg 3610261 tgatggggtg tttcgagccc tctcggaagc agatcagtaa acacctgctt agacaaaagc 3610321 tgggcatctt caggcagcca tgttcccgct tttacctttt cttccgcgta atgctttgtt 3610381 gtgtacgtga gataagaccg aaattcttct gtctgcatag gggttagcat aattgtcata 3610441 tcatctctcc ttcatatatt gactagagga ttttacataa aatagaaaga ggtgttacta 3610501 tcagaataag caactgagat tgataagtca ctagagaaag gagtttcaca tgaataagat 3610561 cgcacccgca gaaatcgcta gcatgctcaa cgattggtac cttgccatca agaaacatga 3610621 agttgaagaa tcctcccgtt tatttgaaga agtgaagcct ttattggatg acatggaaga 3610681 ggatcaggag gtgcttgcct acttctcctt attggaactg cgccacaagg ttttgcttca 3610741 cgaggcgaga ggacagggct ttcagcatga ggagccttct catatgaatg ctacgtctga 3610801 catgctgaaa tattactttt ttctgtttga aggcatgtat gaggcctata aaaataatta 3610861 tgacattgcc attgggctgt ataaagatgc agagcagtat ctcgacaaca ttcccgatcc 3610921 gattgaaaaa gccgaatttc acctgaaggt cggtaagctc tattataagc tgggacaaaa 3610981 tattgtgtcc ctcaatcata cacggcaagc agtcaaaaca ttcagagaag agacagatta 3611041 taaaaagaag ctggcttcag ccctgattac catgtcaggc aattttacag agatgagcca 3611101 gtttgaagaa gctgaggctt atttggacga agcaattcgg atcacgagtg aattagagga 3611161 tcattttttt gaagcccagc ttttgcataa cttcggcctt ctacatgcgc aaagcggcaa 3611221 atcagaagaa gcggtttcga aattagagga ggctctacag aacgatgagt atgcccgctc 3611281 cgcctattat tatcattctg cctacttgct gatacgagag ctgtttaaga tcaaaaagaa 3611341 agaacaggcc ttatcttatt accaagacgt gaaggaaaaa ttgactgctg agccgaatag 3611401 aatatgtgag gcaaaaatag acattttata tgccatttat gcagaagggg gtcatgcgga 3611461 aacgtttcac ttatgcaaac aacatatgga tgacttgttg tccgagaaag agtatgacag 3611521 tgtaagagaa ctttccattt tggctggcga acggtatagg gaacttgagc tttacaaaga 3611581 agctgcccac tttttttatg aagcattaca gattgaagaa ctgattaaac gaacggaggt 3611641 tatataaatg aaaagatttc tgattggcgc aggcgtcgca gcggtgattt tatcaggttg 3611701 gtttattgcg gaccatcaaa cccactcaca ggaaatgaaa gtcgctgaga aaatgattgg 3611761 ataaatgaaa aacccccgcg ggatgcgggg gttcaattta acgaaagaat cctaaaacgg 3611821 tttgtagttt taggattctt tcatcttttc agcgtgattg aaaacccttg aagtctagga 3611881 agaacgagca ttggagcgca gcgaatgttt ggaattcgtg agcaccgaag cgcaggcctg 3611941 acaacgaatg cgagggtttg tcgacacgct gaaacccccg cgggtgcggg ggttttctta 3612001 ttacagcagc ttcttcccta acagggattc tacgagctct actgctgttt tgcccgtttt 3612061 gtttttgtga tcaaggatcg ggttaacctc aacgaattcg gctgaggtaa tgatgcctgc 3612121 gtcatacagc atttccatag ccaaatggct ctcccggtag ctgatgccgc cgacgacagg 3612181 ggttccgaca cccggtgcgt cgttcggatc aagtccgtcc agatcaaggc tcagatggac 3612241 gccatcacat gctgataaat aatcaagggt ttcttcaatg acctttgtca tgccaagacg 3612301 atcgatttcg tgcattgtgt acaccttcat gccgctttcc ttaatgtact tgcgctcccc 3612361 ttcatcaagt gaccgggcgc caatgatgac gacgttttcc ggtttgattt taggcgcgta 3612421 gccttcaagg ttaaccagtg actcgtggcc aatgcctagg ctgaccgcga gcggcatgcc 3612481 gtgaatattg cccgatggtg aagtttcaag tgtattcaaa tcgccgtgcg cgtcatacca 3612541 gatgacgccg agattatcgt aatgcttcgc tgtgcctgca agcgtgccga tcgcaatact 3612601 gtggtcaccg cccaggacaa gcgggaattt tttctcttca atgactttgt tgaccttttg 3612661 cgcgagtttt tcatttcccg ccaaaacgga attcaggttt ttcagttcct cgtcattttt 3612721 gattttttcg cgattgatcg gaatgtcacc gagatcttca accgtatacc ccatgtctga 3612781 cagcctctcg atcagatgag cgtaccggat ggcactcggg cccatatcca ctccgcgtcg 3612841 tgcttgtcct aaatccattg gcattccaat aaccgaaatc gttttatcca tctgtgattc 3612901 cacctcaaca tttaagataa tgtcctatgc gggttataac aaagatgact tgcggacaac 3612961 gtttttaaag ctctagctga cgatttgcct gctggcgttt tttaatgacg acatgataaa 3613021 tgatgtagca aatgatcata aacggtacgc cgcaatacag cgcgatacgc tgctccggat 3613081 caaatgcaag actgatgagc acgaccgtat ttaacgttag gccgatcagc ggaagcaccg 3613141 ggtacagcgg tgttttaaat ttcaaatctt ctatcttccc gccctcacgg atatatttgc 3613201 gtctgaacat gatttgggaa agcgagatcg taatccagcc gacctgcgcg ctcatgcccg 3613261 ccaaagataa cagtaccata tatacggttt cagcctgcgc aaactttgtc agaagtgata 3613321 ggcaggccac agccatcgtt acgattaacg agtacatcgg tacaccgcgc tgatttgttt 3613381 tgccaagcgc tttgaaggct tgtccttcat tcgccatcgc gtacagaata cgtgttgatg 3613441 cgtataaacc tgagttcgca acagataaca gtgcgattaa aataacaaag ttcatgatat 3613501 cagctgcata tgggattccg atttgctcaa atacggcaac aaatggactt tccacgacac 3613561 ccgcctgttt ccacggaatc atgccggcaa tgacaatgat tgaaagcaca aagaacacaa 3613621 gcgttctcca tactgtctgt ttgatggacc gcggaatcgt tttttcaggg tcttcacttt 3613681 ctccggctgc aaccccgatc agctcagtcc cctgaaacgc aaagttcaca gtaatcatcg 3613741 taatcagcat tgcctttatg ccgttcggaa ataacccgtc ttcataaaaa tgtgtcaaaa 3613801 acggcgcctg ctctccgccc ttcagatcaa tcaggccaaa catggcagct ccgccgagaa 3613861 taataaataa aaggataatc aaaattttaa tgcctgagaa ccagaattca gattccgcaa 3613921 aggcttttgt ggtgatcgca tttaaaataa acatcagtgc cgcaaagacc agacaccaga 3613981 tccacacgtc tatatgcgga aaccagcgtt gcatcagctg ccccgctgat aaaaattcaa 3614041 tggcgcatgt aaccgcccag ccgagccagt acagccagcc gaacgcaaac ccgaaggccg 3614101 ggctgataaa tttcgtggca taggtctgga aggaccccga cacaggaaag gcgactgcca 3614161 gctctcctaa gcagagcatg gtcaaaaaca tgataaagcc gcccactaaa taggacagaa 3614221 ccgcgccgag cggtcccgct tggttaatgg taaacccggt tccaaggaag aaaccggttc 3614281 cgatcactcc gcccaatgaa atcatgaaca aatggcgtga tttcattgtc cgctggagct 3614341 gatttccgtt atcttggttt gtattcacat tctgcacccc ttcagcaact tgtattggat 3614401 ctaagctgga acatctgcat ggtgctatcc cagtttgctg tccaaagagt ctctatctat 3614461 ttaatataaa attcacttct tctcataaag atacattata ctaaaatact gtagctgagc 3614521 aaatagggag tgctgatttt tctgttgtaa atttatacaa acgaagtgaa tatcccgcca 3614581 tggtgcggat ttatgcgttt cgcagcacgt gcttaatttt ctctatcgcc caatccaagt 3614641 cctctttgga aatgattaat ggcggtgcaa aacgaatgac tgtatcatgc gtttccttgc 3614701 ataaaagtcc ctcttccttc aaacgctcac aatacggacg tgccgcttca gtcaattcca 3614761 caccgataaa cagccctctg ccgcggactt ctttaatgac agggctgtca atactctcaa 3614821 gctcgctttt aaagtattca ccaagttcaa gagaacgatc cgccagcttt tcatcctcca 3614881 gcacttctaa tgaagcgata gacactgcac atgcaagcgg gtttccacca aatgttgagc 3614941 cgtgtgagcc agggttaaac acgcctagga tctcgcggtc cgccgcaatg caagagatcg 3615001 ggaacacacc gccgccaagc gctttgccca agatatacat atccggaaca atgccgtccc 3615061 agtcacaggc aaacgtcttg cctgtacgtc cgagacccgt ctgaatttca tccgcaataa 3615121 acaagacatt ctcttcctta caaatcgccg ccgcttcctg taaaaatcct tcaggcggaa 3615181 tcacaatgcc cgcttcgcct tgaatcggtt caaacaagaa tgccgctgta ttcggcgtaa 3615241 tggcctgtcg aagcgcttcc acatcgccgt aaggaatgag tttgattcct ggaagcatcg 3615301 ggccgaatcc tcgtttatat tcctcttcag aagaaagaga taccgccagc atcgtgcggc 3615361 cgtggaagtt cccgacacat gcgataattt ccgcttgatt gtcagctacg cccttcactt 3615421 catacgccca gcgtctcgcc gctttcaccg cggattcaac cgcttcggct cctgtattca 3615481 tcggcagaat catctctttg cctgtcagtt tagctgtttt ttcgtaaaac ggcccaagct 3615541 gatcgttatg aaacgcgcgt gacgtgaggg tgattttatc agcctgatcc tttaatgcct 3615601 gaatgatttt cgggtgtctg tgcccctggt ttaccgcaga gtaagcactc agcatatcca 3615661 tatattcatt gccttccggg tcctttaccc aagcacccag cgcttcagaa ataacaatcg 3615721 ggagcgggtg ataattgttg gctccgtaat gagacgtctg atcaataatt tctttggatt 3615781 tagataaagc tgtcatattt gaattccccc ttgttttctg tttcaacatg ttatcctgct 3615841 ttccctttat ataaatgcaa gttctgtgcc aaatcaagaa ttcgtgtgtt ttctacaatt 3615901 ttcgaggaca aggtgcaaaa acattctgat atttcgagcg aaaatttcag caagtgcaaa 3615961 attcttttgc atatcctctc cgttttttta taaaatagaa gcaatattaa gaaaataatt 3616021 gagggaggtt catacagtgg tcaaagacag cgaattcctc acattggttt ttcagagtat 3616081 tttagatgaa atcgatgttg gcctgcacgt ggtagacgag catggaaaca caatcgttta 3616141 taacaataaa atgatgcaga ttgaagatat ggagaagcat gacgtcttga ataaaaacct 3616201 gatggatgtg tttatgtttt caaagcagca ggacagcaca ctggtacagg ctcttcagga 3616261 aggcaagacg attaaaaacg tcaaacagag ctatttcaat aataaaggcc aggaaattac 3616321 gacgatcaat catacatatc ccatcgtcca agacggcaaa atcaggggcg ccgttgaaat 3616381 tgccaaggat gtgacaaagc tggaacggct gatcagggag aatatgaaca aaaaaggcag 3616441 cacaacctat acgtttgaca gtattctcgg caccagtccg gccattcaag acgtcatcga 3616501 aaacgccaag cgggcaaccc gtacgtcatc atctgtcctt ctagcaggcg aaaccggcac 3616561 gggaaaagaa ctgttcgcgc aaagtatcca taatggaagc gatcgttctg gcggcccgtt 3616621 tatttcgcaa aactgcgcgg cactgccaga cagccttgtg gaaagcattt tgtttgggac 3616681 gaaaaaaggc gcgtttaccg gcgctgtcga ccagcccggc ctgtttgaac aagcccacgg 3616741 cggcacactg ctgttagatg aaatcaactc gctgaatctc agccttcagg cgaagctgct 3616801 gcgcgccctt caagaacgga aaatcaggcg catcggttca acaaaggata caccgattga 3616861 cgtacgtatt attgccacga tgaatgaaga cccaattgat gcaattgcag gcgaacgaat 3616921 gcggaaggac ttgtattaca ggctgagtgt cgtcacactg atcatcccgc cgcttcggga 3616981 acgaaaagaa gacattttgc ttctcgcgtc ggagttcatc cagaaaaaca accatctgtt 3617041 ccaaatgaat gttgaacaca tcagcgatga cgtgaagcaa tttttccttt cttatgactg 3617101 gccgggaaat attcgcgagc ttgagcatat gatcgaaggc gcaatgaatt tcatgacgga 3617161 cgagcaaacg attacggctt cccatctgcc ctatcaatac cgcatgaaaa tcaagccggc 3617221 tgacatccca gagccggaaa caccaagaca ccagccagcc gcggacttaa aagaaaaaat 3617281 ggaaagcttc gaaaaatatg tgatagagaa cgtgttaaga aaacacggcc ataacatctc 3617341 gaaagctgct caggagcttg gcatcagcag acaaagcctc caatatcggc tgaagaaatt 3617401 ttctcactcg tctaacgaat aatccggagc aggaagcctg atcagaaaaa cagtgcctct 3617461 gccgatttca cttttcactt caatcgtccc attgtgattg tcgataatcg atttcgttat 3617521 ggcaaggcct aatcccgaac ctccatattt ccgggagcgg gatgggtctg ccttgtaaaa 3617581 ccggtcaaac actaaaaaac gtcacttctt atgcattgaa gaaagaaaat ggcacctatg 3617641 tgtatcacag ccagcaacca cacggtacaa accattaaag tccatgcaaa taacggaagt 3617701 atttgcagct aactgccatt tgctgtttca cgtgtaacat ccatcttgta tttttcttca 3617761 tattcgatat atcctttttc aactgaacgg gcgtgacccc tgttcagttt tttttgcata 3617821 tcaaaacagc ctggcaacga tgccagactg cttttattaa ctgcctaatt ggtctgcgga 3617881 ggacagcttg atatcaacag atttttcttt tccgccgcga taaaacttca ccttcacccg 3617941 gtcaccgact tttttctgat aaagccgttt tcgcaggtca acaatatcat ttactttgta 3618001 tccgtcaaat tccgtgatga catccagttc cttcagcccc gcttttccgg caggtgaaaa 3618061 ggcgtctaca cccatcacaa ccgctccatt ggtgacgttc ttaggaagct ttaatgtttc 3618121 atcccaatga tagcttgcga tgtcacttag cgatttcatc tcaatgccaa ggaacgggcg 3618181 tttgaccttt ccgtatctct ctaaatcctc tatcacaggg atcacgagct tagacggaat 3618241 ggacaggcca atcccttcaa ccgctgactc ggcaattttc attgaattga tgccaatgac 3618301 cttcccatcc atatttaaca aagcgccgcc gctgttccca gggttaatgg ccgcatctgt 3618361 ttgcaggact tcagcgttcc agtcaggctg tccatcaccg tttgaatcta ctgggatcgc 3618421 cctctccgta cccgagatga cgccttgtgt gacagagcct gcaaactcaa ggcctaacgg 3618481 gttcccgatc gcaataaccg gctccccaga cttcacttta tctgaatttc cgaaatcagc 3618541 gactgcttta atcttatcgc ttttcacccg taaaacggca aggtccatca gctggtcgct 3618601 gccgacaaga tcagctgata cacgtgagcc gtctttcaag ctgatttcaa tttgggaagc 3618661 gccttcgatg acatgatggt tggtcacgac ataagcggaa tggtcatttt tcttatagat 3618721 gacgccagag ccgctcccag cctcgccgct ctctccccaa atatctgatt tttggatgtt 3618781 cacaacaccg acaacggcgg gcgacatatt gctgacaatc ttggtgacgg cattgttgac 3618841 actgacattc accgtcctga ttgattcccg gccattgttg ttttgctgct gatctaaggc 3618901 gcctgtatcc agcccttcat ttgaaaggta cggcatgata aacgccatta atacggcacc 3618961 gacaatcacg ccaatcagac tcgaaagaaa atatcctttt ttgcttctct ttggctgttc 3619021 aggagtagta tgttcttcct cacgttcgta atccaccata ttccatcctt tccaagaacg 3619081 ttaatatggt tatattgtgg gttagaaact cctagaatag tcatgattta catagaaaaa 3619141 ttatacagcg caaagcggag tggccttctt cggatcggtg tcgtataagt caaatgtctc 3619201 acccgtcaca aatcctttag aagccaatgt ctgctgcaca gacattcttg ccagctcctt 3619261 catgttgttg tcctggctca aatgcgccag gtaaatacga gacgtctcat cgccaatgac 3619321 atccgtcatc gccaaggcag catcttcatt tgacacgtgc ccgacgtcac ttaaaatccg 3619381 ccgcttaatg ctccatgggt atcttcccat ttgcagcata ccgacatcgt gattgctttc 3619441 aaacacaaat acattcgctg aacggataat gcctttcatc cggtcgctga catatcccgt 3619501 atctgtcatt aacgcgagct ttcggccgct ataatggaat acataaaaca tcggttccgc 3619561 cgcatcgtgg gaaacgccaa acgattcaac atcaagtccg ccgaacgact tcaccgtctc 3619621 cattggaaat acaaactttt gatcggtgtc aattttgccg atttgattct ccatcgcttt 3619681 ccaagtcttc tcattcgcat agatcggaag cttgtacttt ctggcgacga caccaaggcc 3619741 cttaatatgg tcactatgct catgcgtcac aaaaatgccg tctacatcat ccagcttacg 3619801 cccgatctgc gccatcagcc catccatggc ttttccgctc aaaccggcgt ccactaaaaa 3619861 tgcgtgatcc tctgtttcga ggtaaaacgc atttcccgta ctcccgctcg caagtacgct 3619921 aaattgcaag ctcatgtttg tctcactcca ttattttcat tgatctgtat ctaaaatcgt 3619981 actctccaaa gcattcacag taaaatactc ttgtactgtc tttttctcac cgttcacttt 3620041 tttctcgtac tcgaccgtaa ttctccatac cggcgccagc acctgcgtac ttgtcagcgg 3620101 atattgtgct acatagccga atttacagct cttcacagtg ctgtattctt ttaattgatt 3620161 ttgatagtac aatagctcaa ccgcatccat ttcagtaatt aagctttctt tctggatttg 3620221 cttgaaggtc tcaagcgtag tctggtcgta tgacacaacc tcgtttttac cgtttaagtg 3620281 cagcaccact tgcccgatca tattagaggg attgtcggtc ttttggtaaa tataatgacc 3620341 ttcgtacgtt tggaagaaaa taatttcttt cttcgattta tcaaccttcc aaagcttata 3620401 tttttcgcca tcttgaattt tcgaagaaac aagtgcctga gcatcgtcct cgatatcctt 3620461 ctttgatagt gcgattggat ttgcaaactt cattttcagg ctcgttactt tatgatcatc 3620521 actaggcatg tccatcaaag gcttttgatc cttcagcgcc tcaatttcct ccttggagaa 3620581 agacttttga tttgccgtga tccgatagcc ttctgttgct tccttattca agccttcata 3620641 cgtgatatga tcggccttca tgtcatgctc gacatcattt ttaatgactt catattcttt 3620701 gccggtagcc tgccattttt gaaaaaactg atagcctaag aaaatatcta aaatgaggaa 3620761 ggcaacgatg aagattgatt ttgtcttatt ccactccact gttagccccc tccttcctca 3620821 ataaatcctt tgtaatcggc acaatttttc catttacttt catcgcccaa accggttcca 3620881 gttcaacgag aggatcatcg ttggttgatg ttgataccaa ttgataagca aggaagatct 3620941 gatcaatttt gtccgtatca taagcggttt gtttcgaaag cagcatcttc acttcgctgc 3621001 cgcccatgag ctctgtttca cttgttttaa tcggattcgt tccgagactg taattcggcc 3621061 gcttatagct gagaatatca tcattcgccc attgcaccgt aatcgccgat gtcgccccga 3621121 aaggtttggc ggtgctgtta atgaccggga tctgatccat aaaaatatag aagctcaact 3621181 gctggctgtc attgatattg aaaaattgat agtgatccgt ccagcttccg gtatcctcaa 3621241 ggtatttttg gctctttttg attaattcac ctgtttgata ggatgtgctc tgcaccaaat 3621301 tgcgctgctg aaattgcacc tgtctctggc ttagattcac atctaaccgg ctgatcccat 3621361 ctgtcagcac atttctgttg gtgtaattcg aatcttctct tacaatgctc ggatcactaa 3621421 acaaagcctg cttaaaggta tttgttttaa tcgattctgt gacaaattct tttttgtcca 3621481 tcgtaagcgg tttgttcggc agcaagaact ctttctttga gccaatggag aacaaactga 3621541 acgccggcat atttgattgc ctgtttttca agtcgttcat aatgttccgg tagtttgctg 3621601 attcaaccgt cacttcaaga atgagctgct tgctgtatga caccaaatag attttcttgt 3621661 tcgcttttgt ttcattgaac gggatcagaa tatggtcaaa cgaactgtat tcaaacgact 3621721 gattagacca tttaaacagc gtttggaaaa tatcaatcgg gatcgtatcg ctgaattgca 3621781 agtcaagctt ggcttcagaa ccgcctattc cataaaacca gcttttgaat ccagccttgt 3621841 catactgatc cgaaatatct ttaattcctt tcacatccca atgcggcaag tcagaccaaa 3621901 tttcttcata gagggcattg tcatccactt tgtaatgagc gccgtcatca tggataaaca 3621961 tgtcccttgg ccttaccgtt tcagacagct tttgggtggt tttttcgatt ttatgtttca 3622021 cacgaacagt agactctgtt gaggatgagc cttcagaaaa gtttggctgg aacgtccata 3622081 tcccccatgt aaaaacaaga ctgatgacga cgagtaccgt aagtaatatc gtttttatat 3622141 tttcacgctt catcccaatc atcctcttgt tcctctttat atggaagagt aaatgtaatc 3622201 gtcgtgcctt ttccttctat gctgtccgcc caaatatctc caccgtgcgc ctgtaccatt 3622261 tccttggcaa tcgccaatcc cagaccggtg ccgccaagct ttctcgttct cgctttatcc 3622321 accctgtaga agcggtcaaa gactttttcg acatcttttt tcggaatgcc gatcccttca 3622381 tccttcacgc tgatatagag aagttcttcc tcttcattga catcaatcga gaacgtgaca 3622441 tgtccgcctt ccggtgaata ttttaaagcg ttagaaataa tattatcgag cacctgcgtt 3622501 attttatcct ggtcaatctc gacatacaga tctctgtccg gcagattgcg gataaactcc 3622561 acatgctgct cttttgtcat ttcaaaacgg tcaataataa gtgacataaa ccggacaatc 3622621 tgaatccatt cccggttaaa ttgataatct ttactgtcaa atttcgacag ctgaagcaga 3622681 tcattgacaa gccggatcat acgctctgtt tcattttgcg tcaccattaa gaagcgcgga 3622741 gcaatgtctt tattttccca cgcgccttca gctaacgctt ctaaatagct gcgcattgtc 3622801 gtaagcggcg tccgcagctc atgtgataca ttcgcaacga attctctgcg ttcctgatcc 3622861 attttctctt gttcggttac atcgtaaatg acagcgatta aaccatcaat tttgccgtgt 3622921 tccctttgaa tcacagagaa attcacgcga agcaccgtta attcatcatc gcgctcaatt 3622981 tcaagcagca tagaatcctg ctgttccact aaatcttcaa aagtataatt ctcttgaagc 3623041 cccagcaaac tcgtaatcgg catttctaag gctgtttcac gtgaaacgtt caacagttcc 3623101 agcgccgggc tgtttaagag aataatcgct ccgtttcggt ttgtggcgat aacgccgtct 3623161 gtcatataag caatgacaga ggctagcttt ctgcgttctc cttcagtcat cgcctgggca 3623221 tcttcaagct ctctcgttaa gtggttaaac gttgtggcca gctgcccaat ttcatcatgt 3623281 ccatactttt taaccttcct cgagaaattc cctttcgcaa gctccatcgc ctgctttcgc 3623341 atatctgaaa gcgggtgggt aatggttctt gccagaaaaa taccgagaag agccgtcaaa 3623401 acaagtgcca aacctgtgcc ggacgccagt atcgtgttga tcgtcttcat ttgattaaag 3623461 acatcttcca tactcgcgac aacgtagatc gcgcccacaa cctcttggtt ttcagtcatg 3623521 acgggcttcg cggaaataag aactctgatt ttgcttttcg ggtcataata ttttcttaaa 3623581 tacgactgtt tggtagaaaa gattcttttg aaaatcagat cggtcgtttg tttcccagcc 3623641 acttcctcac cgtacggctt tgaagaaccg accacttcat agcttttatc tacaaagcta 3623701 atttcccgaa cctcatcact tttcgtgaag tcattcaaaa tacggctgac gtcatccttt 3623761 atgacggtac tgtcgttatc gctcttatat tcttgttcga tataataaga aaggttgtcg 3623821 attcgctgat tcagcgattg ttcataagag ctgatcagcg acttctctac ctgattgaca 3623881 aaatacacac caatgatttg catggcaatg ataatcaaaa gcacataaat caaggtaatc 3623941 ttaaattgga tcgaccgaaa aaaaccaacc ttattcatat gggcattagt cctgttctgg 3624001 gtttctcaag taataaccta caccacggcg tgtgacgatc caatttggat ggctcgggtt 3624061 gtcctcgatt ttttcacgaa gccggcggac tgttacgtca accgttctga catcgccgaa 3624121 gtaatcatag ccccaaacgg tttgaagcaa atgttcacgg gtcatcactt gtccgatatg 3624181 ttttgctaaa taatgaagca attcgaactc acgatgagtc aattcgattg tttcgtctcg 3624241 ttttgataca acgtacgcgt cagggaagat gacgagagag ccgatatgaa tctcgttaga 3624301 ggaaggctct tcctccgcag gcgctgttgt cagctggcgg cgcaggttcg cttttacacg 3624361 cgccaagagc tcgcgtgtgc tgaatggttt tgtgacatag tcatcagcac cgatttcaag 3624421 cccgataacc ttgtcaattt ctgaatcctt agccgtcagc ataatgattg gcatatcgta 3624481 tttctttctg acttcgcggc atacttcaac gccgtcttta tttgggagca taatatctaa 3624541 aagaattaaa tcaggctgaa gctcttctac catttcaacg gcttcgtttc cgtcgtgggc 3624601 acagtgcact tcatagcctt cttttcttaa gttaaattcc aatatatctg caatcggttt 3624661 ttcatcatct actacaagga tctttttatc catcattttg attttcctcc tgccgaatga 3624721 cttcatttca tctatataac attcgtttca tcacttatgg cccatgtaaa gaatgggtcc 3624781 ttgtctatta taacggttta aggtcaaaag ataaaaaaaa taaaggttta gaaaaaaaac 3624841 acatgtttca cctttatcgc cagttgttta tctattgtca tgctggtcaa ctttttttaa 3624901 aaaagataac tttattgaaa cctcccctca ccggagtgcg tctttatcaa tgacgtcttc 3624961 ttctttgaac cggccgcagg gccggttctc cctttttctt ctattataac actcctcatg 3625021 tttgcctttt tcctaaaaga aaaaacgcac ctacgattgc agatgcgttt ggtaagtggc 3625081 tcgggacgga atcgaaccgc cgacacacgg attttcagtc cgttgctcta ccaactgagc 3625141 taccgagcca aatgttttat ttttctctac taagtaaagt aaaatggcgg tccggacggg 3625201 actcgaaccc gcgacctcct gcgtgacagg caggcattct aaccaactga actaccggac 3625261 cttacagtaa ttgcccggag agctgtcgtg tcagctctca cagacaaata aggaatttag 3625321 caataacgct aaagtaaatc aatgacccgt acgggattcg aacccgtgtt accgccgtga 3625381 aagggcggtg tcttaaccgc ttgaccaacg ggccttcacg aaatggtgag ccatgaagga 3625441 ctcgaacctt cgaccctctg attaaaagtc agatgctcta ccaactgagc taatggctct 3625501 taaagatgtc ggaatttcta tagagcaaac gacttaaatc tagttctcat cttgtactct 3625561 attgaagcag tttccgtaac aacgagattt ataatatcac gaacaaatag aagtggcaat 3625621 aacttttttg gttttttttc atattttttt ctcagaccaa cttatatgcg gctttcaaac 3625681 aaaaaacaag ccccttaaat aggggcttgc agacatattc tatttagttc gcacggtaca 3625741 cactgcgaag gacatttgtt tgtgagcggt ctggaccgac agagaaaata gaaagcggaa 3625801 tgcctgtcag ctgagacaca cgctcaagat aatggcgcgc attttccgga agctcgctca 3625861 agctcttcgc acctgtaata tcctcagtcc agcccggcat ttcttcatat accggctcac 3625921 attcagcaag tgccttaaga cttgctggga attcttcaat gatttcgcct ttgtagcggt 3625981 acgccacaca gattttcaac gtttcaattc ctgctaggac gtcaattgag ttcagagaaa 3626041 gatctgtaat tccgctcaca cggcgggcgt ggcggacaac aacgctgtca aaccagccga 3626101 cacggcgcgg gcggcctgtt gttgttccat attcgcgtcc gacttcacgg atttgatcgc 3626161 cgatttcatc tttcagctca gtcggaaaag gaccgtcgcc gacacgagtc gtatatgctt 3626221 ttgatacacc gacaacgtgc ttgattttgg tcgggccgac accagaaccg atcgtgacac 3626281 cgccggcaac cgggttagat gacgtaacaa acgggtatgt tccttggtcg atatcgagca 3626341 taaccccttg tgcgccttca aataatacac ggcgcccttc atcaagagca tcgtttaaga 3626401 caacagatgt atcgcaaaca tactttttaa tctgctgtcc gtactcataa tattcgtcta 3626461 agatatcctc aagtttaaac ccttctgtct cgtacatttt ctcgagaaga cggttttttt 3626521 cttcaagatt gcgctcaagc ttttccgcaa acgcgtcacg gtctaacaga tccgcgatgc 3626581 gaattccgat gcgggctgct ttatccatgt aagcagggcc gattcctttt ttcgttgtgc 3626641 cgatcttgtt agccccttta cgctcttctt ccacttcatc caatttcaaa tgatacggca 3626701 gaatgacgtg agctctgttg ctgattctca ggttatctgt actcacgttg cgctcatgaa 3626761 gatacgcaag ctctgtgact aatgctttcg gatctacaac cattccgttt ccgattacac 3626821 acgttttatc cttatagaaa attccagacg ggattaagtg aagcttatat gtgattccgt 3626881 caaacttgat tgtatgccct gcgttatttc cgccttgata acgggcgatc acttctgcat 3626941 tttctgatag gaaatctgta attttacctt ttccttcatc gccccattgc gtacctacta 3627001 caactactga agacatgtcc gtgcacctcc gttaaccttt caaaacgatt ctattcaaac 3627061 aaatcaagtt tatcagtgaa gaaacagaaa gtcaattgta aatccgaaca ttaatttatt 3627121 gtaaatctat attcgttcgc ttccattcgt tttataagcg ttttctcact gctttgtcat 3627181 aaaaagcttg cgaaactttc atcctttagc ataagaaaga atcacttgcc tgatatccct 3627241 tttgaattca taaaaacgat ccgccagccg tccgggtcct ctatcgtcac gcccccattg 3627301 ctccagtacg ggttctctga ttcgacctct tgatagccca tgtgctttag ctttgaagtg 3627361 atcgctgcca gttcaactgc attcggcaca taaaaaacaa gaaggctgtc gggatgggga 3627421 acgggggcag tgcttccccc ttcatactgg gtgaattcca aatgataatc ggcatgagga 3627481 aggccgaaca tgacaccgtc atacccgtta tgctgtgaaa attctcctat tcgtttcaaa 3627541 cacagtccct cttcgtaaaa acgaataatc tcatcaagct ggcccgtagg acgcgcaatt 3627601 cggatttgtg ctgcttgaaa agacgaaaaa cgttttccca tattgttacc atctcctttt 3627661 tgcaccattt tattaaaacg ctttcaattt ttcatccgct gagcgaacgt catttcttcc 3627721 atctttcgaa tgaaaaaaac cccaagagca gctcttgggg cttatgcgcc gggcggaacg 3627781 cctgcgtcat caaaacgccg ttccaggttg acgaatttgt tgtattcttt tacgaacgca 3627841 agagacacgg ttcctaccgg gccgttacgc tgtttggcga taataatttc gataatattt 3627901 ttattctcgg tttctttgtc atagtagtca tcacgataaa ggaacgcgac aatatccgcg 3627961 tcctgctcga tacttcctga ttcccggata tcagacatca tcggacgttt atcctgacgc 3628021 tgctcaacac ccctggaaag ctgagaaagc gcgataacag ggacttgcag ctccctcgca 3628081 atcgacttca gttcacggga aatttcagat acttcctgct gacggttgtc ctttgaacga 3628141 ccgcttccct gaatcaattg caggtaatcg atcaaaatca tgcccagccc gctttcctgc 3628201 ttcaagcggc ggcacttggc acggatttca ctcactcgaa tacccggtgt atcatcgatg 3628261 taaatcccgc tgttcgatag gcttcccatt gccatcgtca gcttgcccca atcctcttcg 3628321 gtcaggttac ctgtacggag attctgggca ttgatatttc cctcggcaca gagcatacgc 3628381 ataacgagct gctcggcacc catctcaaga ctgaaaatcg ctacgctctc atcggtcttc 3628441 gtcgccacgt tttgtgcgat gttcagggca aaggctgttt tccctactga aggacgggca 3628501 gccacaatga tcaagtcgtt gcgctggaaa cccgcagtca tccggtcaag ctccgtaaac 3628561 cctgttggaa ttcccgtgat atcacctttt cgattgtgaa gctgttcgat attatcatag 3628621 gtctggacaa ggacgtcctt aatattttgg aaggcactcg tgtttttgcg ctgtgccact 3628681 tccataatcg ttttttccgc ttcactgagt aaatcctcga cctcatcctc acgggtatac 3628741 ccgtcttgag caatcgttgt cgcagttctg attaatcggc gaagaatcga tttttcctca 3628801 acgattttcg cgtaatattc tatgttagcc gctgtcggca ccgagtttgc gatatctgtc 3628861 aaatatgaaa taccgcctac ttcttccagc aggtctgtgt tcgcaagctc tgatgtaact 3628921 gtcaccagat caaccggttc acctcggtca ccgagcacca gcatcgcatt atagattttt 3628981 tggtgggaca ttctatagaa atcatctgga atcaatactt ctgaagccag tgttaaagca 3629041 gacggctgta aaaaaatagc gcctaacacg gcttgttcgg cttctatatt ttgcggagga 3629101 agccggtcat tcagaaggtc tgtcatgcta agcaccgtcc tctcattaaa aaatctccaa 3629161 cctccattct accatttcta cagaaaaaaa atagaaaaat tgtctgtttc ctgttttttt 3629221 cagttagcag attggatcgt ttcggacagt aacaaggcgg gaaaaatgca ataaaacata 3629281 agggaggaat gaaagatgat aaagaaatat gcgattacac ctaatgttga tgcggacggc 3629341 tggtttattg aggtggagaa tgtagcgccg acagctttgt atacgtctaa agacgccgct 3629401 attgaaaagg ccaaacaggt ggctaaggaa aacagtccgt ctaagcttgt aatttatgac 3629461 cagtttaaaa atgtggaaga agaacactca ttttaatgaa tgaaagcctt cgctgcagcg 3629521 agggtttttt agcggttatc ggtttatttc atccattgga tgcctatgtg catcatcaaa 3629581 tctgccgctt tttgatacag atcccactcc ccgatcgaag caaatttccc catcagctcc 3629641 tgaagcttta acctcattgc tatatattct tcgaaagtga cagctttttc agtgtctatt 3629701 tggtgttcct tcagcatttg ttttaataag gataacggtg cgtgcataag aaccctcctt 3629761 acctctttta taacggtcat tttccgattg ctctattcct ttgtgacatc ttcttacatt 3629821 tcacatctga ttcttgtaca atggacagaa gagaggaggg atcttttgtg agacctttgc 3629881 aaatttctgc cgaaactgca caaaagcttg cagagtcctt gaatctgccg cttgaacaga 3629941 tcatgcatat gcctcagcat attctgcttg ccaaaatggc tgaactgcaa aaagaggaca 3630001 aatcatagcc ttcattcaca tacttgctta cctgtttcgg gataatatca tgtatatgtt 3630061 agaaaagagg agtaactgct ttgccacatc cacataataa aaaaatccaa tcattttggc 3630121 tgatcaccgg cattatcttt atcgccttta acttacggcc cgcgatcact tcagtcggtc 3630181 cggtcatcag ctctatccgg gcagagctgc acatgtccaa tggggcagcc ggttttttga 3630241 ccgcactgcc gctgctttcg tttgcagttc tttctccgct tgcacctaag cttggacagc 3630301 gcctcggtaa tgagcgaact ttatggctag gtctcgtgat actgctgatc ggtgttctga 3630361 ctcgttctac cggctatact gccgctttgt ttttcggaac agcacttatc ggcgtcggga 3630421 ttgcgattgg taacgtactt ttgccaagct taatcaaaca taaataccct gaaaagccag 3630481 ggatcatgat cagcctgtat acgacatcaa tgaatatatt cgcagcttta gcatcgggtg 3630541 tcagcgttcc tttagcgacc cagatgaatg gcggatggaa acaagccttt ctcttatggg 3630601 gcgggctggc tttacttgca ttgctaatct ggatacctca gctgcgccat cgagatacgg 3630661 caaaccagac aatgaagctg caatccagtt ccatttgggc ttccaaaatg gcatggtatg 3630721 tcaccatctt tatgggcctg caatcgtttt tattttacag cagcatcgct tggtttcctg 3630781 aaattctccg ttcacacggg attgatacgg caacagccgg atggatggta tcactcatgc 3630841 aatttgcgag tctgccttcc acttttctga cgccagtttt agctgaccgt gtgaaacagc 3630901 agcgcggtat cgttgcggcg ctggcctcag tttatctgat cggcctttgc ggattattag 3630961 cgggcggaag ccatacattg cttgccatct ggatgatcat tatcggtatc ggacaaggct 3631021 ccagcattag tctggccctt actttgattg gtctccgcag tgaaaatgcc caacaggccg 3631081 ctgcgctgtc aggcatgtct cagtcattcg gctacctgct ggcagcagtc gggccaatct 3631141 ttgtcggcta tctctttgac cagacgcatt cttggacgat gccgattgtg cttctcattg 3631201 ctgccctgat cgtaatggga gcagccggac agggagccgg acgagatcga tacattttcc 3631261 agtcagaaaa acaaagaaat tcagcataaa gcggggaaga tatctccgct tttttctttg 3631321 aatatttatg gtttattcat aagtttttca tatttgtttt ttacaatgag acaccataaa 3631381 gaggtgaaaa acgatgaaaa ccaaacgatt cgacgcagcc cttattctta ttttgctagc 3631441 agcagctttt ttgaatacgt atcacatttg gcaggatgat acagcaaacc agtactattt 3631501 ggcggctgta aaaagcatga cgcaaagctt ccataacttt ttttatgcgt catttgaccc 3631561 ttctggattt gtgacagtag ataagcctcc tgtcgtgtta tggattcaaa cgattttcgc 3631621 actgattttc ggtgttcaca cgtggagtgt catcattccc caggctcttg ccggagttgg 3631681 atctgtcttc cttctctaca gaatggttaa gccgactttt ggagttggag cggcccgcat 3631741 tgccgcactt gtcatggcac tgacccctat cgcagtagct gtcagccgga caaacaatat 3631801 cgacagcatg cttgttttta ccttattgct cggttcaact tgtctgctta gggcagtaaa 3631861 acaaggcaag ctggtttggc tgctgacggc atttgccctg attgggctcg cctttaatat 3631921 gaagatgatg caagcgttta tggtattgcc tgcatttgtg ttattctacc tgattgcatc 3631981 tcgggtttct ctgaagaaaa aaatcgggtc cctgcttctg tctcttgtcc ttctgacagg 3632041 cctttcactc tcatgggcga ttgcagtgga ttcagcctct tcctcaagcc ggccttatgt 3632101 aggaagcagc cagactaact cagtgctaga actggccttt ggctacaacg gcacagagcg 3632161 tctgtttggg caaactacgg gccttgcaaa gggtgatatg aatgctgctg gcggagggaa 3632221 catgcagaat caagacaaca tgcaagcgcc aaatggcaac ggttcatctt tttctcagaa 3632281 cggtaatcaa tcattcggaa accattcaca ggcgcctcag ccgcctaacg gacaaaccgg 3632341 cgctctcaat ggaggcggag gcacacctcc cacaggtggc aacggacctg gaaatggagg 3632401 gcctggcggc ggaggcggaa aaagcgtgaa tatgttcggc accggtgatc ctggaccgct 3632461 tcgtctcttc caatcagcac tttccggcca aatcagctgg atgcttccat tctcattgat 3632521 cggattactg ggcgcaatca tcagctggta ccgtgatcgc cgcggacatg ctgctaaaat 3632581 gaaagaaacg ctattctggg cggcttggct tgttcccgtg gctggtttct tcagcatcgc 3632641 aggattcttc caccagtatt atttgattat gctggcaccg ccgattgccg ccctttctgg 3632701 tatcggatgg tatacgatgc accgcttata caaaaataat aaagactggt ccagctatct 3632761 tctgccggca gccgtcttga tcacagccgt gtttcaggtg tatattctga gcgcttatac 3632821 aagccaaatc ggcagtgtat ggatgtatgt cctggggctc ttaggactgg gcatcaccct 3632881 tgcacttctg atgcttaaac gcagccatcc gttcagtaag ctgctgacca tcatcagctt 3632941 gtgcgttctg cttctcacac cagtttactg gtcagcaacg ccgcttctat acggtggcaa 3633001 cagcgtcctt cctgaatccg gcccgcagct caaaggctca gcaaacggcg ggaacatgtt 3633061 ctcttcagag gtcgacagcg ggctcctgtc ctatctgaga aaacacaata ccggcgaaga 3633121 gtatttattt gctactttga caaccgtaac agctgcgcca tacatcattt acgaaaatga 3633181 atctgttatg gcaatgggcg ggtttaacgg cacggatccc attctgactg tgtcggaact 3633241 gaaaaaactg atcaaagaag gcaaagtgaa atacttcctt ctgtcagaaa acaactcagg 3633301 caacagcgaa cttgtttcct ggattaagaa aaacggaaaa gaaataacat ctgacgagta 3633361 cagcggttcc tccagcagca caaacagcgt gcagggaatg cgaagaggac ctggcggaga 3633421 aagccagcaa actctttatc tcgtggaata aaaaaagagg cttggatgaa tccaagcctc 3633481 ttttctatta agcttcttct tttacatgta cctttaacac agcctgcact tcaggatgca 3633541 gcttcacagg cacgtttgta tatcctaatg cacgaatgcc gtccggcagt tcaagcttcc 3633601 gcttatctac tttaatgtta tggtcttttt ggagctgttc agtgatttgc ttgcttgtca 3633661 ctgaaccaaa taaacggccg ccctcacctg attttgcgct aagctcaaca gtcagttttt 3633721 ctaatgtctc tttcaagctc ttagcctgct caagctcagc aatggcttct tttttctctt 3633781 tctgcttttg tccgtttaac gcgctgatgt ttgacgcgtt cgcttcaacc gcgaggcctt 3633841 ttttaattag aaagttatgc gcataaccgt ctgctacgtt tttgacttcg cctttttttc 3633901 cttttccttt tacatcttgt aagaaaataa ccttcatctc tgtacgcctc cctcaaaata 3633961 ctcatctatg gcgtgcttca gccgttccag cgcttcagaa actgaaatgc cggacaactg 3634021 agtcgccgca tttgttaaat gccctccgcc ttccagggcc tccatgatga tctgaacatt 3634081 tacctcgcca agcgaccgag cactgataca aaccgtttgt tcatcccgtc tcgccaccgc 3634141 aaatgaagcc tcaacctcac tcatcgatag cagcgaatcg gcagcctgcg caatcagcac 3634201 ttgatcgaag tattcctctt cattttcagg aagagaagca atcgcaatgt tatctttata 3634261 gaggaccgta tgctggatca gcttcgcccg tttaatatag gaatcaacgg tttctttcag 3634321 aaacttctgc accagcaccg tgtcggcgcc ttttgccctt aaataagaag ccgcatcgaa 3634381 agtccgcgag cccgtgcgga gagaaaagct ctttgtatcc actattatac cagctaatag 3634441 ggctgttgct tcaatcatat tgatttttaa gcgcttcggc tgatattcaa gcagctctgt 3634501 caccaattcc gctgtggaag aagcgtatgg ttccatataa acgagcagcg gatctctgat 3634561 aaactcctca cctcttcggt gatggtcgat gaccacgata tgttcaattt tattgaccag 3634621 ccgttcctcc atgacgagtg acggcttatg tgtatcaacg atcacaagca gtgtgtcatc 3634681 attggaaatc tccattgctt cttcaggcgt aataaatctt gaccacagtt cttcatattt 3634741 tttgatttcc ccaatcaaac gctgcacact tgatccgatt tggtttgggt caatcacgat 3634801 aaaaccatct ttgttatttg cctgagccac ctttaaaatc ccgatcgctg cgccgataga 3634861 atccatgtcg gggaatttat gccccatgat aatcacattg ctgctttcgg tgacgatttc 3634921 ctttaaggcg tgagaaatca cgcgggcccg cacccttgtt cgtttctcca ttgggtttgt 3634981 tttaccgccg taaaacttca ccttgccgtt tggcagctta atggctacct ggtctccgcc 3635041 gcgtcccagt gctaagtcca agctggattg cgccaaatcg ccaagttctt tcagggaaga 3635101 gactgaagcc ccgacaccga cgcttaacgt cagcgctaca ccgtcaaacg aggttttttc 3635161 ccgcacttca tcaagaatcg aaaacttcga attttcgagt tcagttaaga tatgttcatt 3635221 aagtacagca ataaagcgtt ctgaagacgt ccttttcaag aagatcccgt actcctgcgc 3635281 ccaagcgttc agcaaagatg tcacctggct gttcatcgtg cttctcgtct ggtcatccaa 3635341 tccttgtgtc acatcatcat agttatcaag gaaaatatat gccaggacgg ttctttcgtt 3635401 ttcatatagc ttttcaatct ggatttgttc tgttacatca aagaaatata agagacgctc 3635461 atcccgtttg atgacaaccc taaacttgcg gtcattcaat gtaaccgttt ccgattccac 3635521 ctcttgtttg ataagcggca ctaccgattc acaagtatcg taaagtgatc tccccactaa 3635581 agtgctttca ttaaaacaag aggaaagaaa cggatttgcc cattctatat aatattggtc 3635641 attaaaaagc atgattccaa tcggcatttc catcaatgcc tcttcaccga cttttttcaa 3635701 cctgtaggac aacgtagaaa tataagcatc aatctcttgt cgaataagag aatcagcacg 3635761 cttaataaaa aacaaaataa ctgccagcag cagcacttcg acggttccta atatccagtt 3635821 aaaataaaag ctgatgagga ttgtaataat tgacagagca atcaatgcat agatgggata 3635881 ccgaaacagc ggtttttcat aaaagcttgg catttctatc actccccacc atgtgagtaa 3635941 aactcatgtt cacttcacct tattccttat atgaaagccc atatctaaaa cgcctaaaat 3636001 gcgaatggcc gccatgaaga ccggatgcac aaacccaagt atgacagcaa tcacagccgc 3636061 agcctttgga tattgtttct tatggcaata gaaaaagata aatgataaac cttggatgaa 3636121 aatcagaaac ccgagtataa actccccatt taaagcgata gagtacagca tttggccttt 3636181 ttctaaaggc aaaaatgaaa gcatgacaat aatcaaatac agtactacaa cactttgcgg 3636241 aaacttcaac tctctaaaag gctttagatt aggaatatcg ggggagaatc gccttaagag 3636301 cggcttagcg ataaggtaac tgaggaaaga aaaaataact cctaccatca caatagctgt 3636361 tggaaaaaga tattgaacga tacccaattg ttcttccatc agttttaatt gcttctcaaa 3636421 ctgcccagca ttgcccgact gcttcgctac agtttctaca atatcaagag attgccggta 3636481 ttgtgtcatt gcctcatcaa tgatattgat acccaaaaac tgaatgctta tcacaaaata 3636541 gaagacaata ctaagcatat aaataagagc gcccgaaata atggcgtgcc cgggctcttt 3636601 ccttttgaaa aaatgtccca tggcaatgcc ggcgcaagct gacataaaag ctacaataag 3636661 cccgttaaag gacccgacaa taaaaacaac cggaagactg acagcgccca tccatatccc 3636721 tagcttcaat ccatgtctga tcgtatacaa gatcattggc agcggcagtg caaataacag 3636781 aattgttcca atcacaggaa cataaacgac cagaagcgta atgatcgcaa acagactgat 3636841 taaaatagca ccttccatta aagctctcgt ttgtttcact tagtcacctc gtatcatcct 3636901 gaacatacga atagaaaaga gcagcataaa cgactgctct tttgttcatc gctgcaacat 3636961 gctttgcacc gaatgttttt atatcatctc taaattttac ttttatattt taacataagt 3637021 ccaaatcgca agtaaaatga cgctaatgtt tcatgtgaaa catgaaaaag gaaaagacat 3637081 tctttgaaaa gaatgcccat cacaattaat gtttatcatc cataaagcca gaagattcct 3637141 tgtttttctt tttcgttttt ctgacataca taaaaattaa gatcaccagt aaaagggttg 3637201 ttgcttgcag aacgccgctg ctaaacaaga aaaagttctt tatcatgtcc cacattgtgt 3637261 ttcacctctt tgtgcatgtt ctcaacccgt atcctatata aggtgaattt ccctttttaa 3637321 aaacttcaaa acatcatgaa caacattgag cgttgggcat atgctgatat ggaatctgat 3637381 cgataaagga gaattttcac atggatgaac gcagaacatt ggcttggcat gaaacattag 3637441 aaatgcacga gctggttgct tttcaatcaa acggactcat taaactgaag aaaatgataa 3637501 gagaagtaaa agaccctcag ctcagacagc tttataacgt gtctattcag ggtgttgagc 3637561 aaaatttgag agagcttctt ccgttctttc cacaggctcc gcacagagag gatgaggaag 3637621 aagaacgcgc agataaccca ttttacagcg gtgacctgct cggttttgcc aaaacatctg 3637681 tccgcagcta tgccatcgca attacagaaa cagcaacacc tcaattaaga aacgtactgg 3637741 tcaaacagct gaatgctgcc atccagctgc acgcccaagt ttatcgatac atgtatcagc 3637801 atggatatta tccgtcttac aacctttctg aactgttgaa aaacgatgtc agaaacgcca 3637861 acagagccat ttcaatgaaa taaaacaagc agcaaaggag ttccctttgc tgctatttct 3637921 gctgatcctt cactaagccg ttcgaacgat aagattccag cacgtctctg ttggattctc 3637981 cccattcttt catttgcaaa acaatcggtt caagcgtgcg cccaaattcc gtcagagagt 3638041 actctacctt gggcggcacc tggtgataaa cctcacggtg cacgatgccg tccgcttcca 3638101 gctccctcag ctggagagta agcattcttt gagtaatact cgggcagatt cgccgaaact 3638161 cattaaatcg tttcttgcca tctatcatgt gataaaaaag aattcctttc cactttccgc 3638221 caatgacatc tagagtgaat tcaactggac agccttcttt gttcgggtat atattctttt 3638281 tttcactcat tcttgaccct ccaatagtac cttttttgat actacattac attttgcaac 3638341 taatctaccc agtattttac acaccttttc tccttagctc aaagaaaatg cttcttattc 3638401 acatcaattt ttaagggttt gcatgattac acctgcagca agacgtgtta aactatataa 3638461 agattacact acttaaaaaa ggataggagc tatcatggaa aagatactta ttttcggaca 3638521 ccaaaaccca gatacagata cgatttgttc tgcgattgct tatgctgatt tgaaaaacaa 3638581 actcggcttc aatgctgagc ctgtccgcct cggacaagtc aacggcgaaa cacaatacgc 3638641 gcttgactat ttcaaacaag aaagcccgcg tcttgttgaa acagctgcaa acgaagtaaa 3638701 cggcgttatc ctggttgacc ataacgaacg ccagcaaagc atcaaagaca ttgaagaggt 3638761 tcaggtttta gaggttatcg accatcaccg catcgctaac tttgaaacag ctgagccgct 3638821 ttactatcgt gctgagcctg taggctgtac ggctaccatc ttaaacaaaa tgtacaaaga 3638881 gaataacgtg aaaatcgaga aagaaattgc cggccttatg ctgtctgcga tcatttctga 3638941 ttccctgtta tttaaatctc caacttgcac ggaccaagac gtagcagcag caaaagagct 3639001 tgcggagatc gctggagtag atgctgaaga atacggcttg aacatgttga aagcaggcgc 3639061 tgatctaagc aaaaaaacag tggaagagct catttctctt gatgcgaaag aatttacact 3639121 cggcagcaag aaagtcgaaa tcgcacaagt aaacacagtg gacattgaag atgtaaaaaa 3639181 acgccaagct gaattagaag ctgtgatctc aaaagttgtg gctgagaaga atcttgatct 3639241 gttccttctc gttatcacag atatcttaga aaatgattca cttgctcttg caatcggtaa 3639301 cgaagcagcg aaagtggaaa aagcgttcaa cgttacatta gaaaacaaca cagccctctt 3639361 aaaaggcgtt gtttcccgta aaaaacaagt cgttcctgtc ttaacagacg caatggctga 3639421 ataagcaaaa agcatcccgc gtcgggatgc tttttcttat tcacccagct tctcaatttg 3639481 tcccatcaca tcagtaattt gctttgcgtt ttggaccagg tctgactgct ccaattcttt 3639541 aagcgatacc ttgccttcct cggcttgttt caacacatct tcagcgcttt tctgcaaggt 3639601 ttcgttatgc tcctgaatgg ttcgatgaat ctccgctgcg gcatcaggcg gcgttaattc 3639661 attaaaatca gcggcagcct tctgaatcga ctcaagctgc gcttcaagtt tttctttcgc 3639721 ctcggtgtca tttacagctt tctcagccaa ttcaggcgct tcctctgcaa atgtcttcac 3639781 cttctccaca taaccagctg cttcactcgt atagttcaat ccgtcgttca cctgatcaag 3639841 catgccgcat ccgcctgcac tcaaaagtcc cactccggca agtactgtca aaatgatctt 3639901 catcttcagc cccctcatcg tttctttttc attttttctt ttaagatcgg aatcaatttc 3639961 tctttcgcta acggcagccc tttcctcacc aattcacgct tcagccactt tttcagctta 3640021 gacattctga tgctcctctc cctttttgat aaaaatgaaa aaactccacc aatttggtga 3640081 agttcctgaa acaaaaagac cttcaccaaa tcagatttgg caaaggtctc gctaacaatg 3640141 agattgccag caaagccgag gacaccttgt cccgtaatga cgactttact gtgaaagcta 3640201 ctcccctttg gagtgttcat ttttattact ttcattctaa agcaccgatc tgttccagtc 3640261 aaattcctgc cgtttatata aaagcgcgct gtggtattta aaatttgaat ggtttttcta 3640321 tcaggagatc atgctatgac agaggaggtt ttcatcatga gtcaagagcg cgtgaaacgg 3640381 cctgggcata ccagatggta catatcttcg ttacttagcg gcattattat tcttaattat 3640441 tttgaccgag tggccatctc ggtagcggcc cctgcgatac aagattcgtt tcaccttact 3640501 gcaactgaac tcggcatcgt gttttccatt tacacctatt cctatacact gatgcagctg 3640561 cctgtcggaa gtttgctgga ccgttttggg gtcgcatggg tcacgagggt tggaatgaca 3640621 atatggagct ttttaacgat ccttcttgct tttttgcaag gaaaattgct gttgtatctg 3640681 ttccggtttc tcattgggct gacgagcgcc tctgcgttcc ctgctgcctc taaagcaacc 3640741 gctctctggt ttcctccaag tgagcgggga ttggcaaact cactgttcga ttcggccgcc 3640801 aagttttcaa atgtaatcgg cgcgccattg gtcgcctttc ttgtcacaac atttgactgg 3640861 cgtgtcgctt ttttgacgat tggatgcatc aatgtgctgt ttacgatctt tttctggcag 3640921 tattatgaac agcctgaacg gcacaaacgc atttctaaaa gtgaactaaa ctatattcaa 3640981 aaacacaatg ccattacaac agagcaaatc ccttacaaaa cgggcccgct tttaaaaaag 3641041 cttttcacca atcgaaaagt atggggctta atgatcggat ttacagggta cgggtataca 3641101 ttcaacctgc tgctcacctg gcttccgact ttctttaaac atacatacgg tatggatctc 3641161 atgtcgtccg gtttatttac ggcagtgccg tggctgatct caaccatttc cggaattgcc 3641221 gtcggcggct ggctcgtcga ttattttatt aagaaaggct atcctaatac caaggtgtac 3641281 cgaaccgtaa tcatagtcgg aatgagcttt ggctttttct ttttaggatc cattctgacg 3641341 aacaatatta ccgtagccat tatttgcatt tccatcggac tcgccggaat ttccgcaacc 3641401 gctccggtcg gctggtccat ctccgcagaa ctcgcgccga tcggttccgt atccatgctg 3641461 agctccatgg tgaatctcgc aaacaacctg ttcggaggca ttattgctgc gtcactgaca 3641521 gggtatttgt ttgatgtgac aggctccttt accctcagct ttctggtagc tggttttgtg 3641581 ctgttgctgg gattggtttt ttatgtgttt gtattagggg atgtaaaacg aattaaacta 3641641 tagaacatga aaaagagagc tgccagttgg cagctctccc tttacatcaa agaatcggcc 3641701 cgtccccatt taccttctcc tcgtcctgtt cctctatatc aagccccgaa gctagcattt 3641761 cctgctctat ctgttcgagc acctgctcgt tttttccttg aagaccacct tcataatgaa 3641821 aagcatcctg tgtgccgttt tcctctattg tcgctaaaat atcgtggata tcattatggt 3641881 ctcctgaaat ggagccgaat ccctggtttt gttttttata attcacaaaa ccgctgggga 3641941 ggttgtttcc gaggtttaca catgatgcgc tccgagtagt aattcatcag tgtatcaaaa 3642001 tcttcatttt ggattgccac atcacatgca gagatgatgt ctttcaattg ctgttccaaa 3642061 tgaattcccc taatcatcat gattggatat attatacaat gtttgacacg tagggatcct 3642121 tttcattttt gtttttacgg tttcgctggt ccatttccgc agagctggcg ccgatcggtt 3642181 ccgtatccat gctgagctcc atggtaaatc tggcaaacaa cctgttcgaa ggcattattg 3642241 cggcttcatt gacggggtat tttgtttgat gtgacaaggc tcctttacgc tcagctttct 3642301 ggtagccagt tttgttctgc tgcttggatt ggttttttac gtgtttgtct taggggatgt 3642361 aaaacgaatt aagcgggaat aaagagtgct tgtagagaaa acgttgttct ttctacaagc 3642421 tttttagttt tgtgctgttt ttcaagatat tcagctgtca taaaaagaaa atgagctccc 3642481 acataccggc taggtatgtg gcgttcttct tcatgttctg gcatgcagct gtgaggagga 3642541 tttgtttgct caccccctga acctgcgata gctaagcccg tgcagttgtt ttgaacctac 3642601 aaagcttcgt tctatttttt cttttctttt tttagagatt tcctgaaata gaaaagcaat 3642661 cttttctaac cttttcttta tggttttgcc atacataccg agtaacgact ttctggcgtt 3642721 tcgttgattt tgtgtaatat tctcaaacat atttcaggat ttgatttata tgaccgatag 3642781 tctttgcgat caattgttga gtacgtaagt gtatgctgat tcaacaaatg tatctgtatt 3642841 gttcacttta taatgaaatt tccattttgg aagcaaaccc ctgactgggt gataacgtct 3642901 atgtgcgatg gcaccaaaaa cttggaggtc aaatagtcct ttagagatga gagttgttaa 3642961 gtagccggaa tctagagcga cggcttctac ttgaaaatca aatcatgcaa tttagtgatc 3643021 caatcggtca aggtagggct tggaacagaa tcatggactt ttctggagtt gcaaactatt 3643081 aatcgtcctc attaaattta taataaaaat attctcaatt gagcaaatcg cccacccttt 3643141 ttcctttata acataaaatc caatactatc aataaaattc tttacaggtt attacagtta 3643201 agatataata tagttaatct tttacgtaaa aggaggtttt tattacttgt gttgaagttt 3643261 taaataggag taactccatc tccccattac ggtcttcatt taatttcatc ctgagtttta 3643321 tttagttaga tataaaaacg aaaatttcac attattttta actaaccgat agtataaaat 3643381 atatattgaa aggattgtaa aattatgaat aaattcctga agagcaattt ccgtttcctt 3643441 cttgcggctg ctttaggcat atcattactt gctagtagta attttataaa agccagcaat 3643501 gataactata aattccattt acttgtacct tatggctatg gtaatgccta ttcaaatgat 3643561 gcatttagac agaccactca tacagataat ccttggaaag taaatttaca gaaatcggca 3643621 gaaggtaaag gtacaatcat gacattttgg ttgattaaca cagggaatag taaaattcca 3643681 aaagcttcta aaatacataa cgtaaaacaa ggaagcggag ctcattatta tcatgcaaat 3643741 agccagggaa gccatacata tgtagcctta gcagttgaaa acaacaatta cagtgcaagt 3643801 tcttatggta tagatggtgt atgggatgaa gaaacttggt aaacaagaac cttctaaaaa 3643861 cgttggcacc ttttagccac gcgaaaaaat ttagaatgat aatcttttta taagattatc 3643921 atttttattt attctattaa gaattgagtg agaacatgga aagtcatatt tatcgcatta 3643981 tcaaaaataa attaactata ataatattta ctataatcat attaattcct tgtgttgata 3644041 tatcactatt gttaatgact aacacagaat accatcctgc atatgcgttt ttcctttctg 3644101 gcacttccgt agggcatgct tcacaaatga tcctattatg gtttcttccg ctttattttt 3644161 tgttactatg tgctgacgat tctatacaag attataaaac aggatatcat tacattctta 3644221 taagcaaagt tggcagaaaa aaatattgtt tggaaaaaat atttacctct tttatcattt 3644281 catttttgac aatgtttttg tcactaatat taaacttttt attggttcag gttttctttt 3644341 ttaaaggtac atttaaaaat gacttagacc aaattaaatt ccctgataac agcctttata 3644401 cttttagtat ggcccatcct tatatagcaa ttgtgttatt ttctattatt tgttgtatta 3644461 tgtctggatt tgttggagca cttggttcaa gcctcagttt actttttcgt gataagaagt 3644521 atgcctaccc agcaagtttt tttatttggt tcgtacttat actaaaaaac aaatcattaa 3644581 tgtttttatt ccaaccgttt acagaatacg gttataatgt acttctccct atcctatgtt 3644641 tgtctatctt tatttttcta ataataattt ctagtattgt tttatatgag gcaaaataca 3644701 atgaaaatta aaagactact attaatttta tgtttactac tatttttagt tactttatgg 3644761 ttcaaccaga accacactta tcttggaaag aattctatcg cgtcattact atatatgaat 3644821 aatagtacat tcggatatag ttcaatattt gcatatacct tgttttatat tgtcccgttt 3644881 cttatgttac ttagtaactt ttttcattca gaaaacccct acaaagtaat gaggatggtt 3644941 aagcgtaaaa attactacaa gtctaaaatt atggagattg ggtttgtttc tttacttttt 3645001 tcttcaatac atactgttat taatattacg tgtacacata ttttctttag taaaaacttg 3645061 ttggtcgaag caaacttttt atcaatttgt ttattaaaca tgattagttt agtgtttttc 3645121 tacttatcag taggtattat gtttagactt acatacgatc tgtttaattc agtagcatta 3645181 gcaattttta ttgtgtatat aattttagat agcttgtatt tcggcgttaa attattactt 3645241 cctaatggat attgggaacc ctttagagac ttggctatat tcacaaatat gctcaataga 3645301 tattggtcaa cttcaaatct tataatagtt tatattagac agataataat agtttttatt 3645361 ttttatttag ttggatcttc aatttttttg aataaggatt ataaaaaatg aggattaaag 3645421 gctttttcat aactttagtt gcgataatat ttcaggcgtc attatcgagt tataataata 3645481 ataaaaatgt ctttcctttt ttagatggca taccaataag cacctcgggt cattatgagt 3645541 atcaaaatat tttattgtgg tttgtaccta ttgtttccct aagtttttgt ttctctggga 3645601 gtattagaga tacatacatt tcgtatgagc aattaaagtt agtaagagaa catagtagag 3645661 ttaaatgggt aacatctcaa ttcttaataa ttacagttgt acttttaatc tttactttat 3645721 ctcagattgc tatattttat atttattcac ttgtatctct tcataacctt gatattaatt 3645781 ccgttatcaa taaaagattt gttatgatga cactcatgta ttatctaacc ttacttaact 3645841 tatttagttt tcaattattt atggagcttt attataaatc tcaaatagca caattaaata 3645901 taagcgttta tattattttt tcgttaattt tagcaaagaa gttagtgcaa ttaaattctc 3645961 cgaaagttat tcactacttt ttaattccaa actacagtaa tggattaaga actgggttaa 3646021 gctattattc ccaatctgga actgctatta ttgaaccatt attaggtttg tttattataa 3646081 tcattttaca gatttcaata gttatattat ctgtcttaaa gttcaaaaaa atagatatgc 3646141 taaaaagtga gggcttacaa tgattgaggt attaaaccta acaaaaaaat taaaaagact 3646201 acagttttag ataatatctc ttatacattt gaaaaaggaa caatttatgg actatttggg 3646261 agtaatggtt ctggaaagac catgctactt cgtgcattat ccgggttaat agtccctact 3646321 gaagggagta taactattaa aggtgaacaa ttacataaag atatctcttt tcctaaaagt 3646381 gtaggattaa ttatagaaaa tatgcagtta cttcctcagt atgatgcttt tactaacctt 3646441 aaaattttgt caaaaattaa aaagatcgca tcagataatg atatattaga ttctattagt 3646501 agagttggtt tggaaaattt taatagtgta aaggttagta aattctcgtt aggaatgaaa 3646561 caacgattaa atattgcaca ggctattttt gaaaaacctg atatattgct acttgatgaa 3646621 ccaacaaatg cgattgatga aaaaggagtt gcatttgttc atgacattct tttacaagag 3646681 aaaaaaaggg gagctaccat tattattact agtcatcaca aggaagatat tatatcttta 3646741 tgtgacattg cattagaaat gaatcatgga cgtctagaaa cttcagaaaa agtaatatat 3646801 aagaaagata gttagtttaa actggctatt tcttatccaa tgatagactg cagacaagtt 3646861 caactgctgt aatgctagaa aatccaatga aatgctgata attgcgaaga gatatgatca 3646921 gtcagaaaac aaatcttaaa aagaaaaagt aaattcatca atatttctaa taaacctggc 3646981 aaacaacctg ttcggaggca ttatagctac ttcactgacg ggatatttat ttgatgtgac 3647041 aggctcctta cgctcagctt tctggtgccg gttttgtgtt gttgctggga ttggtttttt 3647101 atgtgtttgt attaggggat gtaaaacgaa ttaaactgga ataaagagtg cttgctgaaa 3647161 agcactcttt ttctgcatcg aaagaatact taagataagt cactcccaaa aatcgtaaca 3647221 gtctgacggt taaacataaa cctctgcccg ttccatttta atacggtttg aacatatccc 3647281 aatgagtcgg cgttatacct tcccgctatc cgctggtacg ccaataattc gtatacgccg 3647341 tctctgtcaa aatcaaccgg atacaagccc gataaaggat tcacccatcc ttctatcggc 3647401 atttttaaca caccttggct gttataaatc tcattcaaat attccctgcc cttgtaagta 3647461 aggtcgagga tatacgtttc gttttgctga tgactgataa cgctcgcttt atattgattt 3647521 tgatacctca cactgtactt taattcatca ttcaatacat ctgaattgaa aattcgccgg 3647581 aactgcctgt ttagataggc aaacacatat gcataaatag caccgccgct tccccctgtg 3647641 tccattacta ctgccacatc ctcaatcttg tcgcctgtca tatcccccag aaaaagtgac 3647701 ggattgtatc ccatattgtt ttgaagctga atccgctgct cctgatgggt tctgccatca 3647761 cggatcacca atgtgatatt tctccataac gggctgccgg gcatttgatt tccagttaga 3647821 aagacctcgt caataacgcc gtctcccgtt acatcgccgc gggtagatac aatgattgca 3647881 cgtgaggaga caggctgccg aaatacgtat ggatgttgaa caagtcctct gccttcataa 3647941 aaccaataag gagccattct gatgtcatac acattcaatt gtgtcacctt ccctaatcag 3648001 ctgaatgaat cattatatgc aggaatggca catcaaagac atatcttaca caccaattaa 3648061 atccgtacca tatgaattat caattacaca aagccactcg ccttgcgcat tctttttaaa 3648121 tacataggtc gcccttcttt ccatcgcata ctcggagtcc tttttatccg aatcaagcag 3648181 tgtctgagaa agaacgagta ccgtgtcacc tgcttccaac aggatcattt tcccttgtgt 3648241 cgggacaata tgatgattga aatagttcgc aatcgtgata aacgcttttt tgatttcttc 3648301 cttgcctcgc gcgatcatgc ccggcttcac aactaaaacg gcatcttccg aataataatt 3648361 catcagtgta tcaaaatctt cattttggat tgccaaatca cacgcagaga tgatgtcttt 3648421 caattgctgt tccaaatgaa ttcccccaat catcatgatt ggatatatta tacatcgcta 3648481 gaccactgaa accttgaaaa caaaatgaaa agtatccttt tttcctatat aatcaaatag 3648541 atatatttaa caaagtaccc aagtgaaggg gtgaacatta ttgtctgcgg aagtaacgtt 3648601 acatgacaat atacattatg atttaagtgc ggattgccag cactgttttg gcctgtgctg 3648661 tgtcgccttg ccttatgcga agtcggcaga ttttgctttt gataaagacg ggggcacgcc 3648721 ttgccgcaac ttacaatcaa actatcaatg ttctatacat aaagatctca gagaaaaagg 3648781 atttcgaggc tgctctgcat atgaatgctt tggcgccggc caaaaagtat cccaaatcac 3648841 ttatgaggga aaggattggc gaaacagccc cgaaacggcc aaccagatgt ttgacgtttt 3648901 tcctatcatg cagcagctgc acgaaatgct ctggtattta catgaagctc tttctataga 3648961 tatagccaag ccgattcatt ctgaactgag aaccactttc gaaaaaatag aaaggctcac 3649021 cagactcagc aaagaacgct tgctgacact gcaggtggac gagcatcgag ctgaggtcaa 3649081 tgaatggctg ttaaaaacaa gtgaactggt gcgtgcccaa gcccgccatc caaaactccc 3649141 gaaaaaggtc agccggggaa gtgtcctgat cggcgcgaaa ctgaaagggc ttgatctgcg 3649201 aggagcaaat ctaagagggg cgctgctcat agccgccgat ctgagaaatg ccgatttgag 3649261 aatgacagac tttatcggtg cagatatgag agacgctgat ctcagcggcg ccgacctgac 3649321 cgggagcatc tttttgacac aggcacaggt gaacgccgcc aacggcgatt cgaatacaaa 3649381 gctgccgctg tctgtacgaa cccctgccca ttggaaataa aaaaggaccc gctaacggtc 3649441 cttttttact gatcaattca atcctttttc gttcctctta tccggcattt tcacacttct 3649501 tgccaagtat cccgacagcc ataacgcaac cagcagcatg aaggtgatca taccgacgac 3649561 gcccagccag tgaaaaccag accagaatag ccctccgatt gttccgaaaa cacttgaacc 3649621 ggcgtaataa aagaacaaat acagcgatga agcctgtgct ttgttgtgaa gggctctcct 3649681 gcccacccag ctgctggcaa ctgaatgccc tccgaaaaaa ccgaatgtaa agagggcaat 3649741 ccccagaatt ttcactgcca gcatattgtt tatcgtaaat aacgcacctg caatgacgat 3649801 gaaaatattc atcaccaata ttttcggata gccataccga tcaaccattc ttccaatgaa 3649861 agacgagctg aaaatgccta caatcatcac aataaagatc cagctggaaa atgctttatt 3649921 aagcgaatac ggcgggccca acagcacata cacaatgtaa ttaaacaagg caacattgct 3649981 tccaagcagc aaaaaaccaa tgagaaacaa gctgaatagt ttacggtccc tcaagtggcc 3650041 gatcagagac attcccaatt tcccgagctt caattttctt ggcgtaaaat gcctggatgg 3650101 cggcaaattt ataaaaaata taacactagc aatcaaacta atgacaccaa ttgtccccat 3650161 cgccatatgc caattcaagt actcgctcag gagcccggaa acgatccttc cgaaaacggc 3650221 gccgattgca tttccgctga tatatagccc catcgctgat ccaagacttc cgggttcaat 3650281 ttcttcccca agataagcca tcgcaatcga cggaaggcct gcgagcgcaa cgccttgaat 3650341 ggttctcaat acgagcagtg tatgaaagct cggactaaag gccgatgcca gacagagaac 3650401 cgatgcggcc agcatggaaa tacccataat aggcttgcgt ccccacacct cggataatga 3650461 accaaagaca agcatgctca cagctaacag cattgtggta acagataaag aaagactcgc 3650521 cgcagtaggc gttacatgaa attcccgcgt gaattcctcc atgagcggct gtacgcaata 3650581 tagaatcgca aatgtattga aacccgcagc gaagaaagca aacgtaattt ttcgaaaaac 3650641 cggtgtgcct tttcgaatgt atgtcatcgg gactttatcg gtccctcatc atgttgtgga 3650701 gcactgccat tcataaacaa tcatccttta tttcttacga attcaaacat cctcgagtct 3650761 gtttatatta ttatcttagc accgttgata tatgttgtat aatgcatata aaatatcctt 3650821 ttcatgctta tatgtaataa ggagagatga taattggaat gggaacaact tgaatatttt 3650881 caaacactgg cccggatgca gcacgtcacg aaagccgcaa aaagcctctc catcacacag 3650941 cctgcacttt cacgctctat cgccaggctg gaaaatcatt tgggcgtccc gctatttgac 3651001 aggcaaggac gatccatcag cttaaatcaa tacggacaca tttttttacg acgggttcag 3651061 gcgatgatga aggagtatac cgaaggaaaa gaagaaatcc aagccttatt aaagccagac 3651121 caaggcgtag tctctctcgg ttttttacat acattaggca ccacgctcgt gcccgatctc 3651181 atcggctcct ttcagcagga ataccccaac atttccttcc agctgaagca aaaccactct 3651241 tattggctgc ttgaacgatt aaaatccgga gatctggacc tctgtctcct cgcttcgatt 3651301 aagcctgaaa atccgatcca atggatcaag ctgtggagtg aagaactctt tgtatttgtg 3651361 ccaaatgatc acccattagc cagtcgcgaa agcattaccc tgaatgagat tgccggggag 3651421 cgttttattt tattgaaaaa gggctatgcg cttcggatga cggtcgatga gctgtttgag 3651481 aaggccaata tacagccgaa cattatgttt gaaggagaag aagcaactac tgccgcaggt 3651541 tttgtggcag ccggtctggg catatctatt ctcccagacc tgaaaggctt agaccaaagc 3651601 aaaatcacca aaatccgcgt cagctggccg gaatgtcagc gtgtcatagg aattgcctgg 3651661 ataaaaggca ggtttttatc accggttgct gagaccttta aacaatatgt gatcagccat 3651721 ttttctgagt aggaaggatt caagcatgaa tgtcaaaaaa atcacgtcag aacaggattt 3651781 acatacagcg tttgaaatca gaaaggcagt atttgtagag gaacaaggct gtcccatttc 3651841 ggatgaattc gatgagttcg atacactcca cggtgactgc cagcacatcc tggcttatca 3651901 tcagaatgta cctgttggca ctgcacgtgt ccgtatcgtt ggccacacgg ggaaactgga 3651961 acgaatctgc attctgaagt cttaccgcaa attcggtttg ggaaaagtga tcgtcgatgc 3652021 attagaacgt attgtaaaag aacaaggcat ttctgccttc aaactgcacg gccagacaca 3652081 ggcggcaggc ttttatgaaa agctcggcta tcggactgca tcagaagaat ttatgctgga 3652141 cggcattccg catgtgctga tgacaaaaca agacgattct gcgctataga ttgttcacaa 3652201 atttgtcact tatgagcatg aacggttcat tggtatacta atcaccgatt atggagagaa 3652261 ggaatgattg tatgccagca aataaaaaag aaggccttat atttggcgtg atgatgtgct 3652321 ttggaatggt ttgcgtcatg tcgatttaca atgccatcat caaccgagcc atctacgatt 3652381 tttcactgat gaccgttttt gaaatggtca tcggttttat gatcgccctc ctgttagatt 3652441 tactgttagt gggccccctc gccaagaaga ttgcattccg catgccgttc gacaagacta 3652501 aaaaaattta tgtcatcctt gccatgtcaa cttgtatggt gattggcatg gtactttgta 3652561 tgtctgtgtt cggtttagtg acagcggttc tagcaaatgg gctgaacggg gacagcctct 3652621 tcagtgctta tcttatgatt gtgttgaaaa atttcatcct ggcctatccg ttgcaattac 3652681 tgattatggg cccattagtc agaggagttt tcatgaaatt tgtaaaacca aagctcacag 3652741 ccgcaattta aatagaaaag gagtgagcct gacactcact ccttttgctc atgaatcgaa 3652801 tgtaaaacaa gctccgcaaa agcctctgcg gcaggcagct gccatttttt ctttttgggt 3652861 gtgagtaaat cggatcgagg gcttcaccat gctggagatt tttcagctta tgtttttcac 3652921 ttccattaat ccctatacct taccacatag tttttataca attcttcgtt ataaaggatt 3652981 tcttcgccat gtgaagagca aatgagcgtt ggtttgattt gatctatgat tgagccgctg 3653041 tcgatgttct catttatatc aacactgaat cttcttatag gtgggtgtaa atcctcctta 3653101 cttgtgataa aaaggtcgcc cgtcaatagc gtacgatcga ttttatgata atacacaaca 3653161 tgccccggcg aatggccagg tgttaaatag tatttcagag gcagatgagc aagcgtttgc 3653221 tccgtcagcg gctgtacaat atgggctacc cctgtgttct ccacttcatt tttgttcgga 3653281 tatggctctt ccccattgat gtactttagt tctttctggt gcgcaaaaat cggaatatca 3653341 aatctctcta accattttga tgcacccccg atatgatcac tgtggccatg ggtaagcaaa 3653401 atggcttttg gattgccgat cgctaacgct gccctaattt gagcatcagc aaaacgttct 3653461 attcccgtat caacaatata aacatcatca ccatctttga taaaccaggt atgaaccgga 3653521 atacgaagag gcacatcaag ctcaaattca cattgaaaga catgttctga tagttgtctc 3653581 aaattcacgc aaaccatctc ctgtggaaat tttttgatag ttttaaagaa aacagaagtg 3653641 aacggactat tttcacccac gctcgagctg actggattct tgagaggaaa cgccgatttt 3653701 cgccagcatc agctcaactt gttaacgttg tccattaata atcccttttg ttccccttct 3653761 tcacatattc ccaatcacgt tctatattct tcctcactct atgaaggagt gcagaaatgg 3653821 tttccttttc ctctgaagta aaaccggaca aggccacttc cgtggaatgt tctccttctc 3653881 ttcttaacaa tggatatacc tttttccctt tctcagtcgg gaacagtttt tttatttttt 3653941 tattttgctc atccggcagt ttttgaataa atccctgcat ttccagcttc ttaatggccc 3654001 gcgcggccgt tgtccggtcc acttttatca tttccgccaa tttttcttga ataattcccg 3654061 gattttcgta tatacgcacg agatagagat actgccctct tgttaagtct aaatctttaa 3654121 attcgatgtt gcttatggaa tccaacgctc ttgctatcat gccgatctca cgcaaaatat 3654181 cattcattcc taaaacccct cacgtatttt tgttgcaatt acaacaaaaa tgttttaacc 3654241 ttactattat aagaccacat gcgtgctgta cagtccagac taatatcaga aaaggattga 3654301 ttcataatga atataaaaag aataacaact gaagctgatt tacatgaagc tttaaagatt 3654361 agaagaggcg ttttcattga ggagcaacat gtgtctgaag ccgatgagtt cgatgaattt 3654421 gatacgcttc aggaacaatg ccagcatatc ttggtatatc atgagaatca gcctgtcggc 3654481 accggacgcg cgcgcatcgt tggccataca gcaaagctgg aaagaatctg catcctaaaa 3654541 ccttaccgta agtacggatt ggggaagatc atcgtaagcg ggttagagga aatcatgaaa 3654601 gaaaaaggac tgacttcata taagctgcat ggtcaaacac aagcggcagg cttttatcaa 3654661 aaactgggct accagatttc ttcacaggaa tttatggagg acggcatccc tcacgtcttg 3654721 atgacaaaag aaatatcgcg gaatataaca tgaaatatat gtattacgga ataggcatac 3654781 tcatattaag tttgggcatt tccttaacca tacaatcagg actgggcaca tcacccttcg 3654841 atgccctttt ggttggtctg tcaaaaaaaa tcggtcttac cgtaggaagc tgggaggtcc 3654901 ttatttctgt gatcctctta atctgcaacg ctatattaac gagaaaaaaa cctattttgc 3654961 tgggcttgat tacagcattc attactggaa taggcattga cctatggttg tttgttgtaa 3655021 aaaacaccat ctatctaaac tcgttgttaa gcaaactgat ttgttttgga attggtttgg 3655081 tgctcatcgg tcttggaaca gccatctatc ttcagacgaa attcgcatca acaccgatcg 3655141 atcatttaac acttattatc cgagatctct ccaaaagaac aatattgttt tcaaggacat 3655201 tggtatacgc tcttttctta gtattagcca tcatctttaa aggccctatc ggcatcggaa 3655261 ctcttttaac ggtttgtttg ggaggaatgc tccttcacgt ttttatgcct attgtggaaa 3655321 gacatttctt atcaaagaat agaagaggtt attaagaaac ctcttctcga tccaaaaaac 3655381 gaaacgcaaa acaagccccg tttcgttgtc aattctttat ctctggtact gttgaggttt 3655441 tataatcaat taaaatttat agtaccaaaa aatcgcaatt tcatttgctg ttggaaagtt 3655501 ggaataaagc atcgtatcaa ccgcacctat tataaagtga tgtttggcat aaaaatgaca 3655561 agctgaaata ttaatatctt gggtttcaag cataagacca caaaaatgat tctcctttgc 3655621 ccactcaatc gctttatgta ataatgctgt tccaacacct ttttttctat agtcttttgc 3655681 cacggcaatg tcctctatta gtgcataccc attccagtta gaacggatct taatccggcc 3655741 aatgcagttg ttttcaagat aatataaaaa agccgctttc ccctcttctt caacataact 3655801 aacatccatg tcatcatctt catattgttt aaaataaggt ttagaaaatc gttcctcagt 3655861 atatgtccaa acaccgtttt caaaagcagg tatcattctc ccaaaaacaa cgaaaggttc 3655921 gtttggttta ttgaaatctt tcatattcaa atgagtcatt ttcatgatca tatcaatctc 3655981 cgccaatcga gataatattt agtaaactcg tttcgatact attcaacaac agcttccaaa 3656041 agtgtactct ttaagagaac agcattagat aaggcatcca ttaccttata tatttcacta 3656101 tcttaatgag gtatttcaac agaggcttgt ggtacagtaa aaaggaatag aaacaagaga 3656161 aaagaagatg aacctatgcc cactaacaat aaactcaatg agaaatatca tacttccttc 3656221 aactcgccca caaccctgtt gactagtatc cgtggagaga ggaagctttg acacagcttc 3656281 tgccattgat gacatctcta ttgaagtatc caaaggacaa ccaaggatcg ctctttgact 3656341 ttttcaagaa gaaagtagag tgaataaagg agtgattgag tatgttaaca agagaagata 3656401 tctttaaaca cgtcaaagaa aaatacggta catcgcctga ttacccgtgg gagaaatacc 3656461 caaactatgc ttctttgaga catacatcaa acaaaaaatg gtacggtctt atcatgaatg 3656521 ttctcccaga aaaattaggc ttggatggtc atggcgaaat agatattcta aatctaaaat 3656581 gtccccctga aataagtgat cgcttaagaa acggggaaaa tatcttaccc ggatatcata 3656641 tggataagga acattggatt tcaattgttt tagaacggac agatccagaa ggcgaaatct 3656701 ataacttaat cgagcagagc tttcatttaa ccaagtgaag ataaagagtg ttcctgctaa 3656761 tcaagctgcg aagagtagtg ggcactttca ttttaggata ctgttcttca ctctgtccac 3656821 aaacgcaact tagttcatct ggtgcgagag tgggagaaga atttcaacca acttcttatg 3656881 taaaaggatg aatagttatg acaaataact taaaacagag aagaatcatt ttagatttag 3656941 cagttacttt agatggtttt attgaaggga aaaatggaga agttgattgg tgtattatgg 3657001 accctgatat ggggtttact gattttttaa atcaaattga tactatttta tatggtagaa 3657061 aaagcttcga tttatgggga caatacattc caaaaaatga agaccctgat acagaaaagg 3657121 aactttggaa attggttcat agtaaaaaga aatatgtttt ttccagaaca caaaatgaga 3657181 ttgataatca agccatattt ataaatgata atattcttga agaagtaaat aaattgaaga 3657241 aaaatcctgg taaagacatc tggctatatg gtggagcgag tctcattaca acttttataa 3657301 atttggggct tgttgatgaa tttagattat ctattcaccc tgttgttttg ggagaaggaa 3657361 aaccgttgtt tattgatgta aaacagagga taaatttaaa aatggtgaat acaagaacat 3657421 tttcctctgg cgttgtgcaa atcgtttatc attggaatgg ctaacattgt aaagtaacac 3657481 tcgacagtaa tccttcttat tgaactaaag gggaatccat aaataatggg ttccccttaa 3657541 tatactatgg aattatcaat atcaaatttt ctgtaataaa agaggattga aaaggacgat 3657601 gtctcctcaa ttaacatcat taagcattat agtatatttt cttctccctc ttttaagtaa 3657661 tcggctaagt tttgtattta taaaaaaacg aaagaaggtg atccaatgcc tactaacaat 3657721 aaacccaata gattaatcgc tgagaaatct acttatttta cttcaacatg ctcataaccc 3657781 tgtggactgg ttcccttggg gagaagaagc atatgaaaaa gcgaaacgcg aaaacaagcc 3657841 tgttctcgta tctattgggt atagctaacg atggctaatc taaagaacat gctattgatg 3657901 ccatgtttat tcattttaca aaaaaggatc aaccttgaat tactttcaca agattgatcc 3657961 tttcactcat ttagccatgt ctccgcgaac gtttatatac attcaagatt actagccaac 3658021 aaataacaat gattcctgca aaaagtatga gcatattgct atacaaatag gtagagtgat 3658081 caacgtcaat aggcagcagc ctatgatcta ggaagccgat agataataaa ccgcctacaa 3658141 tcgcaatacc cgttccctct gataaaaagc tcgtgaaatt aagcaaactc attccagcgc 3658201 ccgcttcctt ttctttcaaa ctgctagaca caactgtaga tataactgtt tttgtgaaag 3658261 atagcccccc aaaaacaaaa attactataa ttgtcatgat ccatggtgct gcatctataa 3658321 aaaaggcagc gattaaaaag ccggaagaaa gcaatgcact tccaatagtt agtacataca 3658381 aggaaccttt ccgatcaaca agcaatcccc caatgtaacc aaagatgatg acactcattg 3658441 ttccggggaa aataatgccg cttccaattg ctgcagtact taaatggtga acatctttca 3658501 tcatgtaagg aaccatagag acaaatcctg ctactgtacc aaatattagt cctccgcaaa 3658561 gggttccaat cacaaaaaag acgtttttcc ctaattcagg gtcaacaaaa gggtcctgag 3658621 ctttcctaat gtgttgcaca aatatgaaga aagcaaggat actgatgatc agaaaagaaa 3658681 atctataaga tgttgtaaac agcataaaaa atacgatacc tgcagacatc aatataatcc 3658741 ctgccatatc aatgtgtcct cttattctct cttccttttt caacaatttt ataaggaatg 3658801 gaacggtgat aattgttgca gttggaataa gcagcaaata cgaccaatgg atataatgag 3658861 caaccattcc gccaatagct ggcccaacac cttctcccat tgctaccagg gacccgatca 3658921 ggccaaatgc tttccccctg ttctcttttg gaatatagcg cgcaacgaca accatcacaa 3658981 gagctgggaa tgcggctgca ccaattcctt gaataaatcg ggctagaatg agaataggaa 3659041 agaaagagtg tccaacaaat ccaatgatcg accctaagcc atttaccata atcccaaata 3659101 gaagcagatt tttgatgccc agctggtctg atagctttcc atatagagct gttccaatgg 3659161 agaaggttaa cataaaggct gtattcaccc agtttgcact tgctggcagt ttattaaact 3659221 cgttggcaat atcaggtaat gagacgttca gaaccatttc atttaatacg ctgaaaaatg 3659281 atagaacaca aagccaaatc aaaacttgat tgtgccgtaa agttgactgt gaataagacg 3659341 tattcacaat ttcccctcca ttaatgaggg cagacgcagt ttatagggtc attgatacgc 3659401 ttccctcttt taattgtacc ctgttcattt tattgcactt cataataact ccccctacat 3659461 ttgattgata tgatcttatt atatatagac taaggattaa acttttactt tttttataaa 3659521 aatttgacca gattgcgaaa caaggaaaaa cgttattcgc atttatctca agtggcaaaa 3659581 tgaaacatta gtttatattt tcacatcaca attatcgata agcagtcagt tattgtattt 3659641 gtttaggata actgtggtaa cctgaatata accaacttag gaagaaggtg atcccatgcc 3659701 aaataaaagt aaacccaata gattaatcgc tgaaaagtct ccttatttac tccaacacgc 3659761 ccacaaccct gtggactggt tcccgtgggg agaagaagca tttgcaaaag caaaacgcga 3659821 aaacaagccg gttctggtca gcatcggtta ttcgacgact tgtcattggt ggcctgggat 3659881 aatcaaatcg tgtggaactc cattaaaaga taacagaagc cattttaaac gataatacta 3659941 tttgttcaaa caatacagtc taccttttat ttcattcatt ttctaaaacc tgtaatccgt 3660001 aaccacgcgg tagcaggttt ttttatttgc ttgacttaga gttaactcta aattgtaaac 3660061 taactttaat taaatgagag ggatgatgtt gttgtattcc attagtaaag ctgctgagaa 3660121 gactagtatt agttcgtata cattaagata ttacgaaaag attgggttac ttccaccacc 3660181 aaaacgaaaa aacagtggaa ggcgttttta tacggagact gatattcagt tcatgttatt 3660241 cctgaaaagt ttaaaggaaa caggtatgtc tttggaggat attaatgagt ttgtcaaaga 3660301 cggatgcatt ttggaaaaaa tcaattcgga tgttaaatcg gcacaactct ccccatctat 3660361 aaataaacgt attgagattt taaccaagca cttagagaaa atggaaatta aaaaaaggga 3660421 gctggaagaa gtgatttcta ctacaaaagg aaaactggat acatattatt caattttgaa 3660481 agaggaagtg gaaaacaaat gaaacattta aatatataca taatgttact tggcttctct 3660541 attttcacgg gagctacttt taatcttgca aaatatacag ttggatattt ttctccatcg 3660601 tcttctgcgg catggcgttt cggtttagcg gctgcagtga tgctcatcat tttgattttt 3660661 actgaaggta taaagaagag tcaattacgg aaaaacgccg tttcatacat tgttcttgga 3660721 attataggaa tctttggatt taatgccttg ttttttgttg gtttaaaata tacatctccc 3660781 gttaacggag cattaataat ggggctgaat cctttattaa cagcaattct cgctcgaatt 3660841 atcttaaagg acaacatgac aaaaaaacaa gtactcggca tattctttgc attcatcggt 3660901 gtattgttag tcattacaca aggttctatc gaaaccatta aaaccttatc aatttcagga 3660961 ggagacttaa taatctttac aggtaacgtt tgttgggcac tttatggcgt acttggacgt 3661021 cggtttgtaa aggatggtac accgctatct acaaccactt atacgatggt tattggtgct 3661081 gttagtttaa tagtagtttc cttatttaca tccaaacctg tttctttatc gaacatcccg 3661141 attggagttt ggggggcaat tgcttttatg gcttttttta caagtgtttt gggttaccta 3661201 tggtggaatc aggggattaa agagattgga gctagtaaaa catctttatt tttcaacctt 3661261 gttcccgttg taacgatgat tatttcattt gccgttggaa caccaataaa ggtatttcaa 3661321 gttattgggg ctgtgctagt tatattaggc gttttaaccg cttcgggggt aatacgtatt 3661381 cctaagtaca atactaaaga acagtcagct atataaagaa atagggagta tttttgagaa 3661441 aatgtgttaa gttaaatata cactaattat aggaagaagg tgatcccatg ccaaacaaaa 3661501 gtaaacccaa tagattaatc aatgagaaat caccatattt actccaacac gcccacaacc 3661561 ctgtggactg gttcccgtgg ggagaagaag cttttgaaaa agcaaaacgc gaaaacaagc 3661621 cggttctggt cagcatcggt tattcgactt gtcattggtg ccacgtgatg gcccacgaaa 3661681 gctttgaaga cgaagaaatc gcgcgtcttc tcaatgaacg gtttgtggcg attaaagtcg 3661741 accgggaaga gcggcctgat gtggattctg tttatatgag aatctgccag ctgatgaccg 3661801 ggcagggcgg ctggccgctg aatgtgttta tcacgcctga tcaaaagccg ttttacgcgg 3661861 gtacatattt tccaaagacg agcaaattca atcgtcccgg ttttgttgat gtgcttgagc 3661921 atctgtctga gacgtttgcg aacgaccgcg agcatgtcga ggatattgcg gagaacgccg 3661981 ctaaacattt gcagaccaaa acagctgcaa aaactggtga gggccttagc gaatcagcga 3662041 ttcaccggac attccagcag cttgccagcg ggtttgacac gatctacggc ggtttcgggc 3662101 aggcaccgaa atttccaatg cctcatatgc tgatgtattt gctacgttat gatcacaata 3662161 cagggcagga gaacgctcta tacaacgtga cgaaaacatt ggacagcatg gcgaatggcg 3662221 gcatttacga tcatatcggc tatgggttcg cccgctattc gaccgatgac gagtggctcg 3662281 ttccccactt tgaaaaaatg ctgtacgaca atgcgctgct gctgaccgct tatacagaag 3662341 cctatcaggt cacgcaaaac agccgctata aagagatttg tgagcagatc attacgttca 3662401 ttcagaggga aatgactcat gaagacggaa gctttttctc ggctttggac gcggacacag 3662461 aaggagaaga aggaaagtac tacgtgtggt caaaggaaga gattctaaaa acgctcgggg 3662521 acgatctcgg aacgctgtat tgccaagtgt atgacatcac tgaagaagga aactttgaag 3662581 gcaaaaatat tcctaacctc attcacacaa agcgagaaca aatcaaagag gatgccgggt 3662641 taaccgaaaa agagctcagt ctcaaactcg aagacgcaag acagcagctc ttgaagacac 3662701 gcgaggaaag aacctatccg catgtcgatg ataaagtgct tacctcatgg aacgcgctga 3662761 tgatcgcggg tcttgcgaaa gcggcaaagg tataccagga gccgaaatat ctcagcctag 3662821 cgaaagacgc catcacattt attgaaaaca aattaatcat cgacggccgt gtgatggtcc 3662881 gatatcgtga tggcgaagtg aaaaacaaag gctttatcga cgattacgct tttctcctat 3662941 gggcttatct ggatctctat gaagcttcgt ttgatctttc ttatttacaa aaagcgaaga 3663001 aactgacaga cgatatgatc agcttatttt gggatgagga gcatggcgga ttctacttca 3663061 ccggacacga tgcagaagcc ttaatcgtac gggaaaaaga agtgtacgac ggcgccgtgc 3663121 cttcaggaaa cagtgtggca gctgttcagc tgctgcgtct cgggcaagtc acaggcgact 3663181 tatcactgat cgaaaaagcg gaaacaatgt tttccgtgtt caagccagac atagaagcgt 3663241 atccgagcgg ccatgctttc tttatgcaaa gtgtgttaag gcatctgatg cctaaaaaag 3663301 aaatcgtgat ttttggcagc gcagacgatc cagccagaaa acaaattata gcggagcttc 3663361 aaaaagcctt taagcccaac gactccattc tggtggcaga gcagcccgag caatgcaaag 3663421 acattgcgcc atttgcagca gactaccgca tcatagacgg caaaacaacc gtttatattt 3663481 gtgaaaactt cgcctgccag caaccgacaa caaatattga agaagcgatc cacacattaa 3663541 taagcagcag ggattaagac ccttgctgct tactttttga tttcttatgg taccataaag 3663601 cgatccccgc aaacacaagg ttgaccgcta tcgtaaagaa agcctcccac atcgggttcc 3663661 cccgcgtaac ggtaaacaga gaaggaattc ctccatacac actgtttttt tctgtaataa 3663721 acatacacaa aaacatatta ttcgcggcat gggcgccaag tgatatttcg atgctcccag 3663781 ttttaatcgt gtaatacgtc cacacaaacc caaatgttaa gtactcaatt cctgcccaga 3663841 cagcgccatt gttcatttct ggattcgcaa aatgcaatac gccaaacaat cctccgacaa 3663901 tcagtgtcaa aaatagagga tttttcgtca atctcccgaa agcttgaagc aaaaatcccc 3663961 tgaaaaatag ttcctcagct gatgtctgaa tcggaaccaa aatgagggca gccgctagca 3664021 gccagataaa tcgtgatgca ttaaactctt gcattgaata gctatcagga tgaatcacaa 3664081 aatcaatcaa ttgtacggcg atcattagca agaaataagc aataaaacca aaggaaattc 3664141 tccgccaatt catctttgaa tttggtgtta tcaccgttcg gaaaggccgc ttcaaaataa 3664201 agcgcacagc cagccaaact cccggaatgg cgaataaata aatcacatgg gacaaataaa 3664261 gatctacgag gggatcactc agcacagctt catccaaatc aaacgtgata ttgggattca 3664321 caataaccgt gaacaatata gcgaaaaggt aagctatatt ccctaataca tataacccta 3664381 ccatcaccaa aaaagcgaaa aaatatctcc acaacgtatt gtttccttct ataggacgga 3664441 taaatgaatt cattccttct atgtctcttc ctttcaatga gaatattact atatatttgc 3664501 ataaattggt ctatgaatct actgttttgg aaatctttta agcaaaatta aaatataaag 3664561 tgtgaattta gttcttccat ctagtgattt gaactctgtt gccaatgaac caagatactt 3664621 ataatagtcc caagagggga attttcagtc ttttctacta ctcaaaaggg ggttttttat 3664681 gaatacgatc ttcaaacaaa agaatacaca tcctttctca aacgcagcga atcgtttaga 3664741 ccgccttccg atttcacgcg ttcatttcca agtgttaacc gctctcggca ttgtttattt 3664801 ctttgatctc gcagatttat ttaccctcag caacgtagcg ccggcactga tcgagcattg 3664861 gggcatcccg ctttcaacta ttgctaacgt aacggccgct tcgtttttag gcatgttttt 3664921 aggcgcttca ctgggcggac ggctgtccga tcgaatcggc cgcaaaaaag ccttaaatct 3664981 atttgtcttt gttttctcaa tcgcatcgct atgcaatgct gcggcatggg acattccatc 3665041 tttaatgaca ttccgtttcc tcaccggatt tggcgttgca gccgccatgg tcattacgaa 3665101 tagctatttg gcggaatttt tcccttcaag tgtacgtgga aaatatattt ctttttgtgc 3665161 catgattgga ttgattgggg ttccgatcac caacattgtg tctgcctttg tcattcctct 3665221 tggttcatgg ggatggaggc tagtatttgt atggggtgcc gtcggcctta tttatttttt 3665281 cttcatccac cgtctggaag agtcacctcg ctggcacgaa aatcgcgggg aatatgcgaa 3665341 agccgatgcg atcctcaccc gaattgaaga acaggttgaa aaggagaaag gcccgcttcc 3665401 ggcagcatcc cagcctaaag taagcgaaac tgttaagcag aatgcaggtt acgcaggctt 3665461 attgaaaggc agaaacctca aaattaccat cgtattatct gctgtatgga tttttgaaac 3665521 gtttgggttt tacggatttg cttcatgggt tccaagcctg ctaaaaagca atggcgtaac 3665581 catggaaaat acattatggt ataacgtatt gcattccgtc ggcgctccac ttggcgcact 3665641 gctcggctcc atgatttccg aaagatttca aagaaaatgg attttagctg cgagtgcgtt 3665701 tctgacggcc atcgccgggc tcttatatgg tatgactttt attcccatca tgatcattgt 3665761 atttggtttt atcgtgaata tcacagaacg ggtctttacc tcgaacttat acgcctatac 3665821 atctgaacct tatccgactg aataccgctc gtctggcagc ggtttagcct atggtcttgg 3665881 ccgtttttca aacatttttg gctcattgct tgtcggattt attgccgttc agctcggcta 3665941 tatcagcgtc ttcttattta ttgggggctg ttggctcgca tgctccttgc tgttaatctt 3666001 cttcggtcct aatacgaatg caaaacagat ttaaaaaagt cagtgcggat ctgccgcact 3666061 gatctcatta caattgcttc aaaatccttg cggggtttcc gcctacaaca gtattagcgg 3666121 gtacatcctt agtgacaaca gatccagaag caatcactgc gttatcaccg attgtcactc 3666181 ccgggttaat caccgcccgg cctccaatcc aaacttgatc tccaattgtc acaggcttac 3666241 cgaactcctt cccggatttc ctttcgatcg gatcaagagg atgaccggcc gtgtagatat 3666301 gtacacctgg cgcaatcaaa caatgacagc cgatacgcac ctcacacaca tctaaaatga 3666361 cacagtcaaa attaacaaat gtatgatctc cgatatgaat gtgatagcca taatcacagc 3666421 ggaatgtcgg caaaatcgtg acttgatccc caaccgaacc gagcagctcc ttcaaaagct 3666481 tcgtccgcac tgcatcatct tccggtgttt cgttgtattg tctaatcagc tgtctcgcat 3666541 gcttgcgttc tagtaatagt tgttgatctt ccgaattgta taattctccg gctgccattt 3666601 tttctttttc tgtcctcagc atttaagtca ctccagatgt cagattgtaa tctcgatcaa 3666661 atttccttca tcatcctcaa tcacgctttc atagtagccg tctcctgttg tcctcgggcc 3666721 gtttactact gcgaaaccat ccgccttcaa tcgatcagtc agttcgtcaa ctttctcccg 3666781 gctcccaacg gaaaaggcaa tatgtgccca gcctgtcatt gtttgtgagg gcggatcggt 3666841 cacattccct tttttcataa tttccagcct tgctccggaa tcaaacgtaa taaaataaga 3666901 cttaaaatct tttttctcat tatgatacaa atcattcgct tcgccattaa aatacgattc 3666961 ataaaaagac ttcattcgct ctaaatcatt gacccagacc gctgtatgtt caatctgcat 3667021 ttcttcctcc tccttcgcct tcaatgaagt tataaggtat gaaatgcatt tcagttcaag 3667081 cttttttctt aaatttatgc tgaattttga tatcagcggg ttcatcctgc aaaaatagag 3667141 aaaatgctgc gatgccgagc tgctcaagat tcaaatcaag cgacggaaaa ccaagaacac 3667201 ggctgataga agtatttccc tcgcctatga tttcaacatc ccaattattc tttttggcaa 3667261 atagatgaat tccagctgcc acttcatcac tatttgcata aatagcagtc ggaacccgcc 3667321 cgctcatata aaaatgttca gctgccagct caccatcatt catatcgttg catccggaca 3667381 gcatatggcg gtcttccaac cttccgcaga cagctttata ggccgcagct ttatcagccg 3667441 tgctcgggct cctatcagct tctctgacac acgtaaaagc aatattctca tgcccgcggc 3667501 tctttaaata gcgaaagctc tctgcataag cagtttttct gtcattaaaa gcacaaggga 3667561 catcaatgtc tccggtatcc tcacaagcga tgaccggccc atattcctga taagctaaaa 3667621 tgctgtccca atgattggcg cgggaagtaa tgatgagacc gtctattttc ttcgttctta 3667681 acagctctaa atatttgatt tcaatatcgg ggttataatt ggtggggaga agggtcgttg 3667741 catactcatg ctgaaaagcc gccttggtga ttccgttaac gattttatca aagcagggat 3667801 gatcgctata aggcagaatc acaccgaccg tatgggtttt cccgcgaatg agatcgattg 3667861 cggttcgatt tggtgtataa tccaattcct tcatgacttg atgaacaagc tttctctttt 3667921 cttcagatac atacggatga tgattcaata cacgcgagac agtcgaaaca gatacatttg 3667981 ccagtcttgc gatctctttt atatttgcca tctctttctc cttttcatat aaaaaaagca 3668041 gtaagtgtaa aatccttact gctatctcat catatattga tgataagttc aacaggacaa 3668101 tggtcggaac ccatgacgtc cgctgatatg ctggcatctt caatctgttc cttaaggctt 3668161 tcagaaacaa caaaataatc aatccgccat ccaatatttc tgtcccgggc gccggcacga 3668221 tacgaccacc aggaataagc gccttcaaga tcaggataaa catgacgaaa agaatcaaca 3668281 aagccagctt ctaagaaacg agtgaatgcc tctctttctt gatctgaaaa tccagcgtta 3668341 ttccggttcg cctttggatt tttcaagtca atctcctgat gggctacatt caaatcaccg 3668401 cataaaatca ctggtttttt ctgatccaat tcaagaatat aagacagtaa agcctcttcc 3668461 cattgcatgc ggtaatcaat ccgctctaat ccccttctgg aattgggcgt gtaaacagtc 3668521 atcacaaaca cgttttcaaa ttccagcgta atcactctgc cttcttggtc atgctcttct 3668581 actccgatac cgtagatgac ctgcagcggt tcttgcttag aaaaaacagc tgtgccggaa 3668641 tatccttttt tcactgcata attccagtac acatgatagt cttcaggctg gagatcaacc 3668701 tggccgtcct gtatcttcgt ttcctgaaga catataatat ctgcatcctc ttctttcaaa 3668761 taagagagga aatccatttt tctcatcaca gcccgcaggc cgtttacatt ccatgaaatc 3668821 aacttcatgt ttcatcctcc cccctataaa aaagagcaag aacccgaagg tccttgctct 3668881 ttacatatca gcttactcac cgcttacgta tggaagtaaa gccatttgac gtgcgcgttt 3668941 gatcgctgca gtcaatttac gttggtattt agcgtttgtt ccagttacac gacgtggtaa 3669001 aattttaccg cgctcagaaa caaacttttt aagaagatct acatctttgt agtcgatgtg 3669061 cgtgataccg ttagaagtga aataacacac tttacggcgt ttcgcacgac cgcctctgcg 3669121 tcctcctgcc attgtcattt ccctcctttc tttttcattt taggcgataa tcacattaga 3669181 atggaagatc atcatccgag atgtcaatcg gtttgccgtc gttggcaaat gggtcatcat 3669241 taaagctgtt cccctgattg cgtctctggt tgttttgatt tcccccaaat ggattatcat 3669301 tttggcctcc gccaaagtac tggcctccgc cgctgtttcc ttcgttgtat ccacctgaac 3669361 cagaaccgcc gccgtttttc ggctcaagaa attgaacact ttcagcttgg acctctgtca 3669421 cgaagacacg ctgtccttgc tggttttcat agtttcttgt ttgtaaacgg ccatctacgc 3669481 ctgcaaggct tccttttttc aagaagtttg caacgttttc ggcttgtctt ctccaagtga 3669541 cacaattaat gaaatcggcc tcacgttctc cggactggtt cgtaaatgta cgattcacag 3669601 caagagtaaa cgtagcaaca gccgcaccgt ttggcgtata acgaagctct gggtcttttg 3669661 tcagtcttcc gactaataca actcggttaa gcataagaaa gaccaccttt taccattata 3669721 tatttcaaaa ttgcttattc ttcttcttta acaacaatgt ggcgaatgat atcgtcactg 3669781 atcttagcta gacggtcaaa ttcttgaact gccgcagcgt cagattgaac gtttacgatt 3669841 tggtagaaac cgtcgcggaa atcgttgatt tcgtaagcaa gacgacgttt accccaatcc 3669901 tttgttccag tgatctccgc accgttagaa gtcagaacgt tgttgaaacg ctcgataact 3669961 gcttttttag actcttcgtc aatgtttggg cggataatgt acataacttc gtactttctc 3670021 atctgtttgc acctcctttt ggactaagcg gcccataatg ggcaaggagc aataattcta 3670081 ttactcacaa ttttatatta taccaaagct cttgtccctt tacaactgca tcctatacat 3670141 taaatcggaa atgaataaca tctccgtctt ggaccacata ttctttccct tcaaggcgga 3670201 cttttcctgc ctctttagct cctgccatac cgccgcccgc aagaagatcc tcataagcaa 3670261 ctgtctcagc acgaatgaag ccccgctcaa agtcactatg aataattcct gcacactcag 3670321 gggctttcat gccttttttg aatgtccaag ctctgacttc ctgttctccg gctgtgaaat 3670381 atgttgcgag gccgagaaga gagtaagacg ctttgatcag ctgatcaaga cctgattctt 3670441 gaatgcccag ctcttccaag aacatttgct tttcttcgcc ttcaagctca gcgatttcag 3670501 attcgatttt tgcacacaca acgataactt ctgcgttttc gccggcagcg tactcgcgaa 3670561 tcttcgctac attttcattg ccagatggat cagcaacttc atcttcactt acgttggcca 3670621 cgtacaaaat aggcttcgaa gtcagtaaat ggagctgctt cacaagcttt tgctgctctt 3670681 cagtgaattc tacagatcga gcaggctttt cactctcaaa cgcttctttc agtttagata 3670741 aaatctcaaa ctcaaataca gcgtctttat ctttttgctt cgcaagcttg ctgacgcgtg 3670801 taatccgctt ttcaactgtt tccatatcag cgaggatcag ctcaaggttg atcgtttcaa 3670861 tgtcatcaat cggatcaacc tttccggaaa cgtgtgtaat gttgtcatcg gaaaaagcac 3670921 ggacaacgtg gcaaatcgcg tcaacttggc gaatatgaga taggaacttg ttgccgagtc 3670981 cttctccttt agatgcgccc tttacaatcc ctgcaatatc agtgaattca aaagcagtcg 3671041 gcacagtctt cttcgggttg accagctcag tcagcttttg cagacgatca tccggcacct 3671101 ctacaattcc cacgttcgga tcaattgtac agaacgggta gttggctgat tcggcaccgg 3671161 cctgtgtaat tgcgttaaat agtgttgatt ttccgacgtt cggcaaacca acaattccag 3671221 ctgttaaagc cattctttca tctcctctat ataaaaccgt cattgtatga acgtattttg 3671281 aacctagagc aattataagg aggttcactg gaaaagacaa gctgacaaaa aagcattttc 3671341 agcttgccaa tccctttgat tatgcttttt tcaagcctac taaacagtca aaaagcgtac 3671401 ttcccattcc attatcagaa tttgtatcat ttgtcagtgc attgactgac cctccaaaag 3671461 ccgcccacat gccttcatct atattaatcg tcttcgcatg agcctgcttc atcactttca 3671521 ccttgccctt catgcttccg cggtcattaa agatgacaac ttcgtctcca tcctgaagat 3671581 cctgcccagc cgctatatct ggagaaatat cgacctgaac gtgctgaagc ttttcaataa 3671641 acggcacatg ctgtgaatga ttggaacgct gcggatgaat ggataagagc gtataagggt 3671701 actttccagc taactcctca ttatggaaaa cagattcttc gggcacattt aattgaagcg 3671761 agccgctaaa tcctttttgc tcagctagcg acgaagtaaa ttcaaatttt ccactcggcg 3671821 tcaaaaactg ataatcatcc cacggcacct gttttactgg aagagggagg tggccttttt 3671881 cttttaaacg ctcaagtgtc acatcctctg cttccaatga agaaagcccc atctctaaaa 3671941 attcttgagt gctgtattca aacagctcgc caaacccaag acgttttgca agctctgacc 3672001 agatccagct gtccgatttc gcttcaccct gcggctccac aagcttcttc ccgtactgaa 3672061 cataatgatg atacatactg gaatagtaga tatcttcttc ttcaaaaaca gtggcagtcg 3672121 gcaaaacata atcacacagc tctgcggtat ccgtcataat ggaatcaatc gcgaccgtca 3672181 ttggaacctt ttcaaatgct tgtctcacct tatttgtatt cggcacctga gtcagcggat 3672241 ttccgcacgt cacaataatc atctcaatcg caggatcagc agcggtcaac acttcttcag 3672301 cctgtgtcat cattgaaaaa gaacgggatg ttgtttttaa ttccggcagc gtcagctttg 3672361 tttttgcaaa gctctcacca atctggacat ttccgaaatt cgcgccgccg cccttaattc 3672421 cgacatttcc gcttgccgcc acaagtgcat caatccaacg aatcgttccc ccgccgtttt 3672481 tatatcgctg catgccaagc cccataaaag tagacaccgg accatcagca tacaaacctg 3672541 ccaaatactc cagctcctcc atagaagttt ctgttttcac aataaactct tccagagaaa 3672601 cggtcttcaa aagctctttc acatcatcaa aaccgacaga atgctcagaa ataaacgttt 3672661 catccgttct tcccatctca atcagaacct tcaaaacggc tgccgcaagc cagccgtcca 3672721 ttccaggctt tacagagata tagcggtcgg caagcttagc agtcgggttg aagatcggat 3672781 caatcaccgt aatcgtggcg cccttctttt tcacctgctg caagtgatgg tataagtgca 3672841 tatttgttct tgatacattt cttccccaca caacaacatg cttgctgttg taaatatcaa 3672901 gcggtccgtg accgtacgaa cggccaaaat cccagctttg cgcctcgata ccggagcccc 3672961 agcatatgct tccgacgatt tcggtcacgc cgccatatcc attaaaaaaa cgctgatcaa 3673021 gcgcttttaa cagaccgtta ttcgcataat catggctgtg caaaacagca gtcgtctccg 3673081 acgtttcctt gatttcccga agtttatcgg caatttcatc aagtgcctgc tcccaagaaa 3673141 tccgcacaaa ctcgccattt tgttttttca ttggatagcg aagccgatca ggcgaatttg 3673201 tttttgtctc aagcattctg ccgcggccgc agattttacc ttccgtaatc ggatggtttg 3673261 gatctccgtc cacttttgtt acctttccat catcaacagt caccaaaaag ccgcagctgt 3673321 cccaacaatt cagcggacat gccgactgat gcactttgct catcgccgtc ttctccttac 3673381 cttctatatg aaaaagcatg agtgtcggcc tatttatgaa gtaggctcct catgcttgac 3673441 tagtactttt tttagttttc tttcaaattc tcttctcgga atcataacac tgtgagagca 3673501 tccctcacac ttaattcgaa tatccattcc catgcgtata attttccagc tgttcgctcc 3673561 gcatggatgc ggttttttca tttctacgat atcattcagg ccaaagtctt tatccgccaa 3673621 gacccttcac ctcttttcct aaactgctgt atctattgta caaaaaaact gatcataaga 3673681 gcaatcaaga tacccgaaaa gaaatacatc ctcttatttc catttactca aaataggata 3673741 taagagcaga caaactaaca aatacaaatt gagcatccca tatatcggat acaagaacgc 3673801 gatcaaatca gaaaatccga aagaagtaaa aggtaccatt aacactaaca aaatcaacac 3673861 aatcatccat ctcggcatat gaataaacgc catcagccgg ctggacaaac ccagcaaacc 3673921 agctaccgtc gtcgtgtaaa tcgccaggca cagcaccgcc gtcatacata aaaaaaggaa 3673981 ataaggcgca ccctccagaa cggcaaacag cggtatttca aactgagaaa gggagcccgc 3674041 cagctccacc aacgtttcat tataaacaaa tgagatcacg ccaaaaataa gaccgcttgc 3674101 cacacttgcg atttttgctt ctccgagccc tttcatctct ttcccaacag aggataaaat 3674161 cgcaacaact gaaaggatgt ttaaagaggt aaacgtaatg ctcgcaggcc agttatactg 3674221 ctgggacaaa tcaatcgtcc acgtatggtg atgtgtgctc tgaaaggaga tcagcgcata 3674281 taaaagcccc gctactaaca caggaatcaa aatactattt atagataata ttcctttcac 3674341 atcccacaaa aacaagcaca ctgtcacgat gcaaatcagc gtgattcccc accagaaagg 3674401 aagcttgtac atttgcaggg tcacaccgcc tccggcaatc atcaccatag tcgtcgaaaa 3674461 caaataaaaa atgatgagga catcataaat tttcgccagc catggcccca ttaaatgctc 3674521 cagaaccggc agaaaatgag tggattgaac cttaaaactg attttcatca caatataaga 3674581 cgagaaaatg aacataattg taaacagcac aatagcaagt ccgctttccg ccccaaaaaa 3674641 ctgccatatc tcctgaccgc tcgcatatcc ggccccgatc aggctcccta atatgagcag 3674701 catccacttc attccggctc tccacaacac tatcacctca tagacaaagt tcagcttgtt 3674761 cccgttattg ttactatata aataaaggaa agcaaacatg ccatattttc atagacattt 3674821 gaacacaagc tgaaattatc atacgaaata cacataaaaa agactgctaa tacggcagtc 3674881 taaaaagaga tatttatttg tttgtccgcg gaatgaagaa gtgaacttca ctcttcactt 3674941 ttttctaacc attcctacct attcaagtgt ttcataagca gaccattgct tgatcatgat 3675001 cgaggcaatg ggggacaata cttgtaatcg cccactaacc attcatatca tgccctctac 3675061 ttttttaaaa tctctggtgc catacacaaa gcataaaaaa tcatactgct ggatatactg 3675121 taaacaacct tacataacta cacacaccat agcaattctg ttacctacta taacaaggaa 3675181 gtgaaaccca tgaatcgaaa aggcgggctt ttttcttctc aggaacgagt aaagcaatat 3675241 gtttcacata cagatgctgc agcggcaaaa caaatccaaa ccatcctttc ttcatcctta 3675301 cgtaaagctg ctggcaaacc aattgtcgtg gtttgtatcg gaacagaccg ttcaaccggt 3675361 gactcattag gcccgctcgt aggaatgaaa ctcaaacaga tgcagctcac cagattccat 3675421 gtctacggaa ccttatctga ccccgtccat gctgtgaaca tgaaggataa aatcaatgac 3675481 attcataaat tacataaaaa cccatttgtt atagcagtcg atgcatgctt aggccgcgtt 3675541 aagagtgtgg gttcatttca aatcggggac gggccattaa agcccggagc cggtgtacaa 3675601 aaagaccttc ctgaagtggg agatcttcat attaacggaa tcgtgaatgt gagcggtttt 3675661 atggaatatt ttgtattgca aaatactaga ctcaacttgg tcatgaatat ggcaaatgtt 3675721 ctagcggaag gtttgagttt aacagatcgg acagagtgga ggcaagaacg ccttaacccg 3675781 ttgcaaaggc tcactgggcg catataaaat aaaaaccatc ttcgtttgaa agatggtttt 3675841 ttcatttatg attctcgttc agacaaaagc tctaaaatcc ggtcaaggtc ttcattagag 3675901 aaaaattcaa tttcgatttt gccttttttc ttctgtcttt taatattaac tgttgttcca 3675961 aaataatttt ggagatagga ttcccgttct tttagaaccg catctttcac aggttctttt 3676021 ttctttgttt cacgtggaac attctgattc aactgctgaa tcagctgctc aagttggcga 3676081 acattgagct gctccgcaat cactttttgt accagcggtt caagcttatt tttgtttttt 3676141 aagccaagaa gcgtgcgtcc atgtcccata gaaagcgtgc cttcggcaat aagctgttga 3676201 atattttctg gcagtgtcag cagtcttaaa tgattcgcaa tatgcggtct gcttttccca 3676261 agacgtttgg caagctgctc ttgtgtgaga tctaagtgtt tcaaaaggga gtcatatgcc 3676321 tgagcctctt caagcggaga taaatcttca cgctgaaggt tttctaataa agcaatttcc 3676381 ctcattaacg cctctgataa ttcacggaca atggccggaa ctgtatctaa acctgccagc 3676441 tttgccgctc gaaaacgccg ttcacccgca acaatatcat agccttttaa agattttctg 3676501 acgataagcg gctgaagaat gccatgctgc agcacagatt cttttagttc agctaatgcc 3676561 tcgtcatcaa agtgttttct tggctgataa ggattagggc gtaaatcggc aattttaatt 3676621 tcttcaactg tctcttcaga caaatctacc tgattaaata acgcattaat cccttttcca 3676681 aggcctttag ccattcgcag ccacttcctt tgctaaatct aaatatactt ccgcacctct 3676741 tgaccgcgga tcgtataaaa tgatgggttt tccgtgactc ggtgcctcac tcagacggac 3676801 attacgcgga ataactgtct tatatacttt atccctaaaa tactttttaa cctcttcaat 3676861 cacttgaatg ccaaggtttg tccgggcatc aagcattgtc agcaatacac cttcaatcat 3676921 taaatcagta ttcaaatgct tttgcacaag acgtactgta tttaataact ggctgagacc 3676981 ctccaaggca taatattcgc actgtacagg aatcacaacg gaatccgagg cagtaagggc 3677041 attaatcgtc agcaagccca atgacggcgg acaatcaatg ataatataat cataattttg 3677101 ctttactgct tcaagcgctc tcttcaatct cacttctctt gatattgtag gaaccagctc 3677161 gatctcagcc cctgcaagct gaatcgtcgc aggaatcaca tccaagttct ctactgtcgt 3677221 tgctttaata atatctatta catctgcatc atctactaaa atatcgtaca cacactgctc 3677281 tacatcggct ttttcaatcc ctaatccgct tgtcgcattt ccctgcggat caatatctac 3677341 cagcagaacc cttttcccta tgtaagccaa acatgcccca aggttgacag acgtcgttgt 3677401 tttgccgacc ccgccttttt ggttcgtaat tgctatgatt tttcccacga tgtcacctac 3677461 tttcacatga acatgtacta tcttgcttct attctatcaa aaaaagatta aagcgtttca 3677521 tttttttcat cattttgttc cgaatcagaa gggaaataat tgaaaattca agcacgcttt 3677581 atgctttctc ttataaattc tgcaatttct atgttttttt gacttaaaaa aggaatttct 3677641 taaagaaaaa aagaagaagt cacagtacag aacgtggaaa caggatggtg agaaaatggt 3677701 ttatcaaacg aagagagatg tacccgttac gctgatgatt gtgtttctca tattactgat 3677761 acaagcagat gccattgttc cttttgtgct gggaaatatg agagtttccg gctggatcat 3677821 ttttattctg ctgactcttt taaatggact catcatttgg agctttattg acctaaaata 3677881 tgtattgaag gaacaccatc tgatcattaa agccggattg atcaaacatc aaattcctta 3677941 tgaaaacatc gataaagtcg ttcaaaaaaa gaaactatgg tccggttttc gtctgatcgg 3678001 ctctcgccat gccatcacaa tatattatca ggggggatgg ggacatgcag taatttcacc 3678061 gcaaaaatct gaagaattta tccacaagct caaagaaaag aattctaata taataatatt 3678121 cactaaaagt aagtgattac cttttgttaa aaatataaaa agctctcctg cttttcagga 3678181 gagcttctat tttggtatgc gaatcgttaa ttgaatatat tcttcaaatt cttcttcttc 3678241 cgtattcaat tttacaccgc tgtcttccac cattgatagt gactggcgaa tcgtgttcat 3678301 cgcaattctt gtatctctgc tgaatgcttt gcgtctcggc tttggctttc tctggccttg 3678361 ctccagcatt ttcaccacgc ggtcttctgt ctgctttaca tttaaacttt tctcaataat 3678421 ctctgtgagc agtgtgactt ggagctcagg ctgtttcagc ggaatcagtg ctctggcatg 3678481 gcgctcggtg attttcttct ccataatcgc ctcttggacc ggctgaggca gctttaataa 3678541 ccgaagctta ttcgcgattg tagactgccc ttttcctaag cgctgtgcga gtgcctcctg 3678601 tgttaaatca tgcagctcaa gcagcctagc ataagcatgc gcttcctcaa tagaagacag 3678661 ttcttcccgc tgcaagtttt cgattaacgc cacagaagcg gtttccgtgt cggaaaaatc 3678721 cttaataatt gccggaatct tttcccactc aagcgattgc accgctctcc agcgtctttc 3678781 acctgcaatg agttcgtatt ggccttcttc ttctgtatgc ctaacaacaa tcggctgaat 3678841 aatgccgtgt gtatgaatgg tcattgctaa ctctttgatt ttttcatctg agaaaatggt 3678901 gcgtggctga aaacggttgg gaacgatagc atttaccggt atttccagaa tctcttcttt 3678961 gtttgtatca tgttcagcaa tctccggctc ctgttccttc tcaccaagcc cgaagaaacg 3679021 agagaatgaa tgcttcatgt acctacacca cctttaaaaa ctgccatttt tataattcta 3679081 ttttctcatg gtttttcctg ctgtacatcc atcaattttg atgaaaatat gatggtattg 3679141 tcatatcagg ctgtctaaat tacccttcaa ttggcgattt attaggagtt cccggttttc 3679201 ttggatactt cttaggtgta ttttttattt tgcgtatcac cataatatta cgatcgcttt 3679261 cttcaatagg cagcttaaaa gaatggatat tctcaagttc tcctccaagc gtcgtgattg 3679321 cttttttgcc tgcattcagt tcttcttcag ctgatgcggc ttttaaagca acaaataaac 3679381 cgtttttctt caccagaggc aagcaaagct cactcaaaac agataatctc gcaactgcgc 3679441 gcgccgtcac aatatcatag ctttcacgca cgtctttccg ttgcccgaac gtttcagctc 3679501 tgtcatggca gaatgttgta ttctccaatt gcaaagcttc agacaacttt tctaaaaacg 3679561 taatccgttt gtttagtgaa tccacgattg tgacatggag gtgcggaaag catattttta 3679621 tcggcagact tggaaaaccc gctcccgctc caacatcaca aatcgtgttc acctgattga 3679681 agtcgacata aaaagcagct gtaatggaat cataaaaatg ctttaaatac acttcttttt 3679741 tctctgttat tgaagtcaga ttgatttttt cgttccattc aaccagcatg tcgtaataca 3679801 gctcaaattg ctccagctga cggggagaaa gggagatccc tttttccgcc aaaccagaag 3679861 tgaattcttc aatattcatg ccgtcatcct ttctactcgg ctatcttcgc aatgcgtccc 3679921 tgctctaaat acaccaatag aattgaaatg tccgccgggt ttacaccgga aatgcgggaa 3679981 gcctgggcaa cagacaaagg ccgtacattt ttcagttttt gacgcgcctc ggtcgcaatc 3680041 cccttaattg cgtcataatc aattcggtct ggaatttttt tattttccat cttcttcagt 3680101 ttttccactt gctgaagaga tttttcaata tatccttcat atttcacttg gatttctact 3680161 tgttctgcca cgtcttgagg aaccggcact tctggcggcg ccagttttgt gactgtttca 3680221 tagttcattt caggacgttt catcaagtct gtgccgcgaa ctccatcttt caattcgctt 3680281 ccgccaagag aacggatata ttcttgattt tccggagacg gcttgataat tacagaatga 3680341 agacgttttt tctccgcctc gatcgccgct tttttcttct caaaagccgc atagcgctca 3680401 tcagaaatca atccaatgcg atgtccgatt tctgtcagac gcaaatcagc attgtcatgg 3680461 cgaagcagca atctgtattc cgcacgtgat gtcaaaagac gatatggctc attggtacct 3680521 tttgtcacaa ggtcatcaat cagaacacca atataggcgt cagaacggct tagaattact 3680581 tcttcttttc caagcgcttt tcgtcctgca ttgattcccg ccataatccc ttgtcccgca 3680641 gcttcttcat aaccggatgt tccgttaatt tggcctgcag tataaaggtt tgtgattttt 3680701 ttggtttcaa gtgtcggcca tagctgtgtc ggtacgattg catcatactc gatcgcatag 3680761 ccggctctca tcatttgcac gttttcaagt ccaggaatcg ttgcaagcat tctttgctgt 3680821 acgtcttctg gaagacttgt agataaacct tggacataga cttcctgtgt atttctgcct 3680881 tccggctcaa ggaagatttg gtgacgcggt ttatcattaa aacggacaac tttgtcttca 3680941 atggatgggc agtatcttgg gcccgtacct ttgatcatac cggaatacat cggtgaacgg 3681001 tgcaggttgc tgtcaataat ctcatgtgtc tcagggcttg tatatgtcag ccagcaaggg 3681061 agctgatctg tgatatattc cactgtttca tatgagaaag cgcgaggcac atcgtcacca 3681121 ggctgaattt ccgttttgct gtaatcaatc gtgtcgcttt taacgcgagg cggcgtacct 3681181 gttttaaaac gaacaaggtc aaaaccgagt tcctccaaat gctcagaaag cttaatagaa 3681241 ggctgctggt tattcgggcc gcttgagtaa gacagatcgc caagaatgat acgtcctctt 3681301 aaatatgtcc ctgtcgtcat gacaactgct ttcgcacgat aatgtgcgcc tgtttgtgta 3681361 ataacgcctc ggcattcgcc gtcttcaacg atcagccgct ccacaattcc ttgcagcaat 3681421 gttaagtttg gttctttttc aagcgtattt ttcatttcgt gctgatattg gaatttgtct 3681481 gcttgcgcac gcaatgcacg aaccgcagga ccttttcctg tattcagcat tctcatttga 3681541 atatgtgttt tatcgatgtt tcttcccatt tctccgccga gcgcgtcaat ttcgcggacg 3681601 acaatccctt ttgcggggcc gccgacagac ggattacatg gcataaatgc aaccatatct 3681661 aggttgatgg tcaagacaag cgttttggcg ccttggcgtg cagatgcgag ggcagcctca 3681721 acaccggcat gcccggcgcc aatcacaatc acatcgtatt ggcctgcttc ataccccatg 3681781 attctagttc ctcctttaat tattttccta aacagaattg agaaaagagc tgatcaatta 3681841 agctttcgtg gacagaatct ccaatgattt cccctaaaag ctcccagcat cttgtaaggt 3681901 caatttgcac catgtcgatc gggacatcct gttcgatgcc gctaagcgca tcttcaatgg 3681961 cgcgttttgc ttgctgtaaa atagtgatgt gacgtgtgtt gctgacataa gtcagatcac 3682021 cgctttcaat ggcacccgtg tagaacagtg attgaatcgc ttcttccaga tcattgatgc 3682081 cttcctcttt taaaagagat gtcgtaacaa ctggacgtcc attggcaagc tcacggacac 3682141 gttcagtgtc aatcttcggc tcaaggtcag tcttattcaa aatcacgata acatccatgc 3682201 cctcaacggc ttcaaaaagc ttcacgtctt cttcagaaag ctcttcacta taattaagca 3682261 caagtaaaat caggtccgct tcctttagga cctggcgaga acgttcaaca ccgattcgct 3682321 caacaatatc ctctgtttca cgaatacctg ctgtatcaac cagacgaagc ggaacgcccc 3682381 ttacattcac gtattcctca atcacatccc gtgtcgttcc gggaatatcg gttacaatgg 3682441 cttttgcctc atgaacgagg ctgttcagaa gagatgattt tcctacgttt ggccggccga 3682501 taatgacggt agaaagacct tcacgcaaga tttttccttg ctcagaagtc ctcagcagcg 3682561 tctcaatttc ctttttcacg gcggttgcct tttcgactaa aatctgatgc gtcatttcct 3682621 ctacatcatc atactccgga taatcaatat tcacctcaac atgggccagt gtttctaaaa 3682681 tctcactgcg caaacggcgc accaaagcag aaagacgccc ttccatttga ttcatagcaa 3682741 cgttcattgc ccggtccgtt ttcgctctga ttaagtccat aaccgcttcc gcctgtgaaa 3682801 gatcgattcg gccgtttaaa aacgcacgtt tcgtaaattc accaggctct gccagtctcg 3682861 ctccctctct caatgcaagc tgaagcactt ggttcacagt cacaattccc ccgtgacagt 3682921 taatctcgat gacatcttct cgtgtaaaag ttctcggcgc ttttaacact gataccatta 3682981 cttcctcaac gacacgatcc gaaggtctgt ctacgatatg accataatga atcgtatgtg 3683041 attcgaccga gctgagtgtt ttccccttcg gtcccttata aattttatct gcgatttgaa 3683101 tggcttctgg tccgctcaac cgtacaatcg caatcgcgcc ttctcccatc ggtgtggaaa 3683161 ttgccgcaat tgtatccatg ttgttcacct ctctttactt atacttcatc tatataaaaa 3683221 aatttttatt atgccaaaac taaaagataa catagtttgg ttcgaagtgg aagatttgtt 3683281 atccacagaa atagaaattc gtcccttatt actttaactt atccacatgt gaataacaat 3683341 taattttatt tcctgaactt cctttttatc aacaggatac acctaaaaag aaaaaactta 3683401 aacggcaaaa ccttgatatt actaggaaaa gtagattttt cggatacaaa aaaaccgaaa 3683461 tccaattttt atcggacttc ggttttatgc tatcttttat gggaaataac gagatgacga 3683521 ttttcgcctt cacccattga atatgttttg atctggtggt ttgcatatcc agaaagagta 3683581 tcgtgaataa tttttctttc gctggacggc atgggctcaa gctggatgga ttttttcgtt 3683641 ttcaaaacct ggtcagcaag cttgatggcc agctggctca gtgtttcttt tcttttcaaa 3683701 cgatagtttt ctgcatccac cgtcacattt ttatattggc ctggataacg gttaagggca 3683761 agctgtgtca aagtttcaag ggcgtttaaa gtttgtcctc ttttcccaat caacaatgct 3683821 gccttttcac ctgttatatg atatctcact gtctttttgc tttcttgaac agtcacatca 3683881 gacttcccgg caatggcttc ggcaatcgtt tgaagatata acttcgcttg ctgaatcgga 3683941 tcaatctttt caaccagctt tacgatcgca ggctttttac cgaaaatacc gagaaaccct 3684001 ttgtttccct cttcaataac agtaatttct accttatcct tcgttaatcc caactcttgc 3684061 aatccggact gtactgcttc atcgacattt cgccctgcag cagtcacatt cctcactttt 3684121 tctttcctcc ggctttttgc ggctcaggat tttttttaat atcaggtcct ttaatgagga 3684181 aagtttgcgc aatcataaac aagttaccaa ctacccaata aagagaaaga gccgccggga 3684241 agttgatcgc aaatacgata atcataattg gcataatcca aagcatcatc gccatttgcg 3684301 gattttgctg cgcattgcca gccatcatca gtttttgctg aacaaatgta gcgacaccgg 3684361 caacgatagg aagaatatag taaggatctt tttctcctaa gtcaaaccat aagaagctat 3684421 gctctgaaat cgcctgggtt ctcatgatcg catgatagaa tccaattaaa atcggcatct 3684481 ggatcaaaat cgggaaacat cccgccaatg gattgacacc atgcttttgg aataaagcca 3684541 ttgtttcctg ttgaagcttt tgctgcgttt tttgatcctt tgagctgtat ttttctttaa 3684601 gcttttgcat ttccggctgt aaagcctgca tcgctttcga acttctcagc tgcttaatca 3684661 tcagcggtaa aattaataaa cgaattaaaa tggtaactag aataattgaa agcccgtagt 3684721 tatctcccgt caatttcgct acatacgtaa tgagctcaga caatggatat actacgtact 3684781 tgtcccagaa atgcggacta tctgcagtga tcggctcttt cacactcgag catccagcca 3684841 aaagcatgaa tacgccaacc atacttaata gcaaccctat tctccttttc aacaacattt 3684901 cctcctataa ttaatcttta cactctttta ttgcaaagca tacttgtatg tattttagca 3684961 tctttcagtt ttaaatggtg tctttttctg atcaaccaga aaggaagcgc ttttaaaagt 3685021 tgtaagaaag cagtggtgat gcctactttg acgaagattt cttatataat gaagactttc 3685081 tgaatagatg ctgcagactt tttttcgttt cctcatatgt cagctggctc gccggttttc 3685141 tggcaataat gatgtaatcc ttttccttca gtctctcttt ctcttcaaga aaggcctgcc 3685201 gaatcaaacg tttgatccga tttcgcatca cagcattgcc aatttttttg ctgacggaaa 3685261 gcccgacacg cagttcatca ttttcaggct gatcaagcgt atataagaca aactggcggt 3685321 ttgcaactga tgtcccatgt ttaaacactt tttgaaaatc ttcatttttc tttaaacgat 3685381 ttcgcttctt caaatgactc actccgatac tggctggcag aaacttttaa aatttattat 3685441 gaacatgaga tgcatctgaa ccaggaagca tgccccggtt cattacgcat cacatctatc 3685501 ttttcccata acgtgaaaaa agaccactga cattattcag tggcctaagc tgataatact 3685561 tttctgcctt tgcggcgacg gcgtgctaaa actagacgac cgttttttga actcatacgg 3685621 cttctgaagc catgaacttt gctgcgttta cggttattcg gttggaatgt tcttttcatt 3685681 tatgacacct ccctcgagga atagctgtta aagacagtct tacttattat atttgcgtta 3685741 cctattcatt gtcaacttca ctagtgcttt tatttcttgc aaccataata ggataccata 3685801 ccttttcaac tttcgaaacc ttatttttta gattccttaa ttttacggaa aaaagacaaa 3685861 ttcaaacaat ttgcccctaa aatcacgcat gtggatatct ttttcggctt tttttagtat 3685921 ccacagaggt tatcgacaac attttcacat taccaacccc tgtggacaag gttttttcaa 3685981 caggttgtcc gctttgtgga taagattgtg acaaccattg caagctctcg tttattttgg 3686041 tattatattt gtgttttaac tcttgattac taatcctacc tttcctcttt atccacaaag 3686101 tgtggataag ttgtggattg atttcacaca gcttgtgtag aaggttgtcc acaagttgtg 3686161 aaatttgtcg aaaagctatt tatctactat attatatgtt ttcaacattt aatgtgtacg 3686221 aatggtaagc gccatttgct ctttttttgt gttctataac agagaaagac gccattttct 3686281 aagaaaagga gggacgtgcc ggaag //